RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Revolution in Industrial Environment: Ambient Intelligence Technology for Systemic Innovation in Manufacturing SMEs' (AMI-4-SME), addressing dissemination and exploitation.

assistant: **Impact**

The project aims at proposing a new, revolutionary scheme for systemic innovation of industrial working environments in SMEs by applying AmI technology. The actual approach of implementation of the AmI concept is oriented to surround people with electronic environments, sensitive and responsive to their wishes. AMI-4-SME will provide an essential RTD contribution in the migration of this approach to the manufacturing SMEs.The project will develop:- Two new manufacturing concepts for 2 scenarios within an extended SME context where AmI technology is likely to bring a breakthrough for SMEs: dynamic reconfiguration of manufacturing and assembly lines and multi-stakeholder involvement in maintenance process. AmI systems aim to bring the human operators in the centre of these processes, assuring their highest flexibility.- Set of 3 innovative AmI technology building block prototypes, specially tailored to SMEs needs: New mobile multi-modal services assuring compatibility and workflow support in 2 addressed scenarios, by applying agent technology and semantic web; Innovative smart tags combined with agent technology to allow their active roles applicable in shop-floor; a Speech Recognition System radically enhanced w.r.t. robustness and interoperability, to be applicable in shop-floor environment and on mobile devices, by improvements in language modelling and in searching algorithms.- Knowledge Forum, including a repository of AmI technology structured according to its reference applications in SMEs processes, allowing SMEs to effectively identify AmI technology to realise their innovation objectives.- A new methodology for systemic innovation of industrial environment and organisation of work in SMEs based on AmI technology where the involvement of multiple SMEs within busi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NECROTOXIGENIC ESCHERICHIA COLI (NTEC) INFECTION IN FARM ANIMALS: EPIDEMIOLOGY AND PATHOGENESIS' in the context of a Fourth Framework call.

assistant: **Objectives**

Diarrheic and septicemic colibacillosis of the neonates and young animals are the most common and devastating bacterial diseases in farm animal industry. Most Escherichia coli strains are commensal inhabitants of the gastraintestinal tract but some strains express virulence factors that enhance their ability to cause a wide variety of intestinal and extraintestinal diseases in calves, lambs, piglets, and human beings.Besides enterotoxigenic, verotoxigenic, and enteropathogenic E. coli there is evidence of the emergence of other types of pathogenic E. coli.The so-called NecroToxigenic E. coli (NTEC) which produce the Cytotoxic Necrotizing Factors (CNFS) 1 and 2 must be recognized as a major developping problem on the basis of (i) epidemiological data; (ii) experimental infections in piglets and calves; (iii) activity of CNFs and of NTEC on cell cultures; (iv) association in clusters on the chromosome or on a plasmid of the cnfl and cnf2 genes with genes coding for other putative virulence factors, especially adhesins of the P, 5, F17, and AFA families The research goals of this proposal are: (i) the comparison of NTEC strains from various animal species and human beings at the bacterial and molecular levels; (ii) the definition of the contribution of the CNFs to the pathogenicity of NTEC strains at the molecular, cellular, and wholeanimal levels. In the first part of the proposal, classical and virulence associated properties of NTEC1 and NTEC2 strains, their putative virulence factors and plasmids will be studied and compared by classical and molecular epidemiology techniques. The putative colonization factors will be precisely identified, characterized and compared at the molecular level with already described members of their respective families. Finally the diagnosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Renewable Hydride Donors and Their Utilization in Catalytic Reduction and Deoxygenation Reactions'.

assistant: **Objectives**

The production of chemicals, plastics, solvents, etc., contributes to 20 % of the Gross Value Added in the EU, where sales have doubled over the last 20 years. Despite this dynamism, the chemical industry is energy intensive and 95 % of organic chemicals derive from fossil oil and natural gas. To sustain the growth of this industry, the replacement of fossil feedstocks with renewable carbon, phosphorus and silicon sources should be encouraged. Nonetheless, such a sourcing shift represents a paradigm shift: while the development of petrochemistry has relied on the selective oxidation of hydrocarbons, the conversion of renewable feedstocks (e.g. CO2, phosphates, silicates or biomass) requires efficient reduction methods and catalysts to overcome their oxidized nature.Today, no reduction method meets the criteria for a versatile and energy efficient reduction of oxidized feedstocks and the aim of the ReNewHydrides project is to design novel reductants and catalytic reactions to achieve this important aim. At the crossroads of main group element chemistry, organometallic chemistry, electrochemistry and homogenous catalysis, I propose to develop innovative and recyclable reductants based on silicon and boron compounds, and to utilize them to tackle catalytic challenges in the reduction of C–O,  P–O and Si–O bonds. The overarching principle is to build a balanced synthetic cycle, where the electrochemical reduction of functionalized and oxidized substrates is ensured by silicon and boron based hydride donors, with a high energy efficiency and selectivity.This project will foster innovative routes in the utilization of renewable carbon, phosphorus and silicon feedstocks. It is therefore of high risk, but ultimately extremely rewarding. The results will also also open-up new ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Testing solid earth climate connections through mid ocean ridge time series' (T-SECTOR).

assistant: **Innovation**

A central problem of understanding the Earth system is quantifying climate-solid Earth feedback that requires time-series studies. One important time series is the climate (sea level) record that shows transitions between ice ages and warm periods for the last millions of years, involving vast mass transfer between continents (ice load) and oceans. Volcanism is sensitive to such pressure changes, but its response to glacial cycles is largely unknown for the global mid-ocean-ridge (MOR) system, where 80% of Earth’s volcanism occurs. Models of MOR response to sealevel fluctuations predict changes in crustal thickness, chemistry of lavas and hydrothermal activity. Establishing high-resolution time series on MORs, however, has previously not been possible, because the sea floor is rapidly covered by sediment as it moves away from the MOR and thus cannot be directly sampled. Recent studies, however, show MOR eruptions deposit samples of lava as glass on nearby sediments for up to 100 ka. These carbonate-rich sediments can be precisely dated by oxygen isotope stratigraphy and provide an archive of ridge eruptions (glasses) and hydrothermal activity (trace metals) in the sediments that can be sampled by gravity coring. Through closely spaced new cores to be retrieved during multiple research cruises, a high-resolution time series of volcanism and hydrothermal activity can be achieved and directly linked to the climate record, whereas seismic techniques can be used to determine variations in crustal thickness over time. We propose to obtain integrated data sets for all these processes from slow, intermediate and fast spreading ridge segments over the past 1.5 Ma in unprecedented detail. The results of these glass, sediment and crustal thickness time series will allow us to uneq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Precision Docking of Very Large DNA Cargos in Mammalian Genomes' (DNA-DOCK) targeting Horizon 2020.

assistant: **Abstract**

Gene editing has developed at breath-taking speed. In particular CRISPR/Cas9 provides a tool-set thousands of researchers worldwide now utilize with unprecedented ease to edit genes, catalysing a broad range of biomedical and industrial applications. Gene synthesis technologies producing thousands of base pairs of synthetic DNA have become affordable. Current gene editing technology is highly effective for local, small genomic DNA edits and insertions.  To unlock the full potential of this revolution, however, our capacities to disrupt or rewrite small local elements of code must be complemented by equal capacities to efficiently insert very large synthetic DNA cargos with a wide range of functions into genomic sites. Large designer cargos would carry multicomponent DNA circuitry including programmable and fine-tuneable functionalities, representing the vital interface between gene editing which is the state-of-the-art at present, and genome engineering, which is the future. This challenge remained largely unaddressed to date.We aspire to resolve this bottleneck by creating ground-breaking, generally applicable, easy-to-use technology to enable docking of large DNA cargos with base pair precision and unparalleled efficiency into mammalian genomes. To achieve our ambitious goals, we will apply a whole array of sophisticated tools. We will unlock a small non-human virus to rational design, creating safe, flexible and easy-to-produce, large capacity DNA delivery nanodevices with unmatched transduction capability. We will exploit a range of techniques including Darwinian in vitro selection/evolution to accomplish unprecedented precision DNA integration efficiency into genomic sites. We will use parallelized DNA assembly methods to generate multifunctional circuits, to accel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-Dimensional Convexity, Isoperimetry and Concentration via a Riemannian Vantage Point' (CONC-VIA-RIEMANN).

assistant: **Concept**

In recent years, the importance of superimposing the contribution of the measure to that of the metric, in determining the underlying space's (generalized Ricci) curvature, has been clarified in the works of Lott, Sturm, Villani and others, following the definition of Curvature-Dimension introduced by Bakry and Emery. We wish to systematically incorporate this important idea of considering the measure and metric in tandem, in the study of questions pertaining to isoperimetric and concentration properties of convex domains in high-dimensional Euclidean space, where a-priori there is only a trivial metric (Euclidean) and trivial measure (Lebesgue).  The first step of enriching the class of uniform measures on convex domains to that of non-negatively curved (""log-concave"") measures in Euclidean space has been very successfully implemented in the last decades, leading to substantial progress in our understanding of volumetric properties of convex domains, mostly regarding concentration of linear functionals. However, the potential advantages of altering the Euclidean metric into a more general Riemannian one or exploiting related Riemannian structures have not been systematically explored. Our main paradigm is that in order to progress in non-linear questions pertaining to concentration in Euclidean space, it is imperative to cast and study these problems in the more general Riemannian context.As witnessed by our own work over the last years, we expect that broadening the scope and incorporating tools from the Riemannian world will lead to significant progress in our understanding of the qualitative and quantitative structure of isoperimetric minimizers in the purely Euclidean setting. Such progress would have dramatic impact on long-standing fundamental conjectures regar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Induced electrodeposition of nanostructures as nanowires and nanotubes consisting of cobalt-based multilayers for MEMS applications' in the context of a Seventh Framework call.

assistant: **Objectives**

Purpose of the project:This project is focused on the synthesis by induced electrodeposition of nanowires and nanotubes as multilayered structures consisting of cobalt alloys with refractory metals like Mo and W. Hereto the superfilling of nanopores present as arrays in anodized aluminium oxide (AAO), will be investigated in-depth.  First proofs of principles have been recently achieved by the applicant. The background of the host institution on electrodeposition in micro-pores (e.g. vias used in microelectronics) and its modeling is a most important support to this project.Objectives of research:- To develop at the host institution the scientific insight required for the lab demonstration of the technological feasibility of the novel concept of producing nanostructures (nanotubes, nanopores) with different aspect ratios in AAO by a low cost electrodeposition from environmental-friendly aqueous electrolytes,- To transfer the scientific knowledge to a third country with the objective of nurturing present collaboration and to explore the possibility of further collaboration between researchers and industry inside and outside EU,- To train an experience researcher from a developing country by a European specialist on electrodeposition and tribological testing.Expected research results:- The electrodeposition of cobalt-based homogeneous and multilayered nanotubes and nanowires engulfed in anodized aluminium, and as free-standing products after release from anodized aluminium.- Scientific insight on the role of electrochemical parameters on structural and functional properties of electrodeposited nanotubes and nanowires either engulfed or released from anodized aluminium.- Mapping of the functionality of nanotubes and nanowires made of compositionally modulated layers in vie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INVENTORY: Unique Online B2B Marketplace for Industrial Products' (INVENTORY) targeting Horizon 2020.

assistant: **Abstract**

Intral AS is an Estonian SME providing SaaS (Software as a Service) solutions for wholesale and retail inventory management and e-commerce solutions with the brands ERPLY and Shoproller. We have been established in 2000. The company brings together a strong team of serial entrepreneurs and industry experts. We provide point-of-sale services to approximately 410 000 customers from nearly all countries with key clients like Sony, Walt Disney, Garmin, United Nations and BMW. ERPLY was selected as a winner of Seed Camp in 2009, highlighted as a start-up to watch by Wall Street Journal and RWW in 2010. The total revenue including firms related to owners was €10.5 million in 2014. ERPLY raised $2 million in funding in 2010 from Redpoint Ventures and Index Ventures. INVENTORY is a business model innovation project with the objective to create the first online business-to-business marketplace for manufacturing SMEs, which connects industrial companies with new clients and suppliers across the EU. INVENTORY is targeted to 22 million SMEs in the EU who are seeking for opportunities to expand their client base and find new suppliers to optimize costs. As the outcome, the INVENTORY project increases visibility and competitiveness of SMEs on the EU market by creating conditions for an efficient market. INVENTORY provides product recognition systems, standardised and comparable product information, real-time automated inventory management, deposit service, extensive compatibility with other software and simple set-up. These are all essential characteristics of an efficient and effective marketplace that current European market lacks.The objective of the feasibility study is to identify and assess technical and commercial feasibility of INVENTORY. We want to conduct more extensive res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrating the associated candidate countries into the 6th Framework Programme through networking activities and improved NCP services' (INTEGRATING-ACC), addressing dissemination and exploitation.

assistant: **Impact**

This Specific Support Action is an experiment" in establishing and testing work practices (principally networking methodologies and best practice guidelines for National Contact Points) which can lead to a better integration of the ACC scientific community into the 6th Framework Programme using the instruments designed for the thematic priorities (Integrated Projects, Specific Targeted Research projects, Networks of Excellence). It mobilises the skills of a very relevant group, the National Contact Points, whose role it is to promote the Framework Programme within their countries.The NCP community is very familiar with the barriers met in the ACC and is ideally situated to overcome them since it has direct access to the scientific communities and to a number of networks (e.g. national research programmes, networks of liaison officers in universities, research organisations, other NCPs, IRCs etc.). The proposed activities will: actively promote the research capacity in the ACC (e.g. by inviting the ACC NCPs to information days in the Member States), analyse and reinforce the network."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The physiological role of E2F1 acetylation: a gene targeting approach', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

To complete and diversify her scientific expertise, Dr. Ianari has decided to join Dr. Lees' lab, a leading lab located in a top-level research organization (MIT¿ USA). The aim of her project is to study the role of E2F1 acetylation in the DNA damage response and in the development and homeostasis of the normal tissues. E2F1 is a transcriptional factor that possess both oncogenic and tumour suppressive functions. The spectrum of E2F1-regulated genes is quite large and comprises genes involved in the regulation of development, differentiation, cell cycle progression and apoptosis. Dr. Ianari has recently demonstrated that DNA damage specifically activates E2F1 apoptotic potential in an acetylation-dependent manner by the selective relocalization of transcriptionally active E2F1 from cell cycle genes to the promoter of the proapoptotic p73 gene. Indeed, E2F1 acetylation is the main determinant of the outcome of E2F1 activity in response to DNA damage. Whether this pathway is specifically restricted to maintain tissue homeostasis in the presence of unrepairable DNA damage, or is involved in additional cell regulatory functions, is presently unknown.The aim of this project is to use a gene targeting approach to generate a mouse strain that produces a version of E 2F1 that cannot be acetylated but is otherwise regulated physiologically. Dr. Ianari will combine highly innovative and sophisticated techniques (knock-in mouse model generation, chromatin immuno-precipitation and micro-array analysis) and multidisciplinary approaches (developmental biology, molecular biology and experimental oncology), to provide insight into the underlying mechanisms of tumour development that will aid the development of new selective cancer therapies. This experience will advance Dr. Ianari' s i