RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Differentiation of pro-inflammatory T cell subsets in vivo' in the context of a Seventh Framework call.

assistant: **Objectives**

Our understanding of T cell differentiation impacts on vaccine development and on the treatment of (auto) immune disorders. T cells are key players in inflammation, a crucial component of the immune response to pathogens that causes severe damage to the host when uncontrolled. The cytokines Interferon-(IFN-) and Interleukin-17 (IL-17) are critical mediators of the proinflammatory activity of T cells usually designated as “T helper 1” (Th1) and Th17, respectively.Here we propose to investigate the contribution of all T cell lineages - CD4+ and CD8+ cells, and NKT cells – to global Th1 or Th17 immune responses, using various tools including a IFN-/IL-17 double reporter mouse. Importantly, we will study Th1/ Th17 differentiation in vivo, inmodels of infection with Plasmodium berghei or Mycobacterium tuberculosis. We will analyse theindividual and combined contributions of the distinct T cell subsets, their cellular interactions andpotential interdependence in lymphoid organs and in target organs of infection.We further envisage a molecular understanding of how innate (and NKT) and adaptive (CD4+ and CD8+) T cell subsets acquire their respective capacities to produce IFN-or IL-17 in vivo. We will dissect (pre-/ post-) transcriptional mechanisms of regulation of Ifng and Il17 expression in the various T cell subsets, ultimately at the single-cell level. We aim at characterizing networks of transcription factors and microRNAs that regulate Th1/ Th17 differentiation either in all or in specific T cell subsets. We are particularly interested in addressing the constitutive expression of IFN-or IL-17 by innate T lymphocytes, which is set up in the thymus. We will define the molecular components of this “developmental pre-programming” of and NKT cells in co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Emergency Management in Large Infrastructures' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project EMILI (“Emergency Management in Large Infrastructures”) is a capability project which aims at a new generation of data management and control systems for large Infrastructures (CIs) including appropriate simulation and training capabilities. This new generation of control systems is needed in order to improve the security of large Infrastructures like power grids and telecommunication systems, airports and railway systems, oil and gas pipelines under future technical, economic, organisational, political, and legal conditions. This is especially important in the case of emergencies and crises. Large Infrastructures are cost intensive, large, complex technical systems. They are frequently operated at their limits. Today, they are changing their characteristics rapidly in various respects. These CIs depend on each other and interact with each other in many ways. Even small disturbances may trigger avalanches of failures – in the same system and in depending ones. Quick and adequate reactions are key factors in safe and efficient operations of Critical Infrastructures today. Currently used data management and control systems of large Infrastructures mainly collect data from their own system and process them in a more or less pre-defined way. In order to adapt today’s control systems to the new challenges - especially to an efficient management of emergencies - we need a new generation of these control systems, their methodology and technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and assessment of autonomous parvovirus-based vectors for the selective transduction of cytokine genes in tumour cells' (1994-1998).

assistant: **Concept**

a. RATIONALE. Certain parvoviruses were found to become localized in tumours. This oncotropism results from the greater capacity of neoplastic cells for amplifying and expressing parvoviral DNA. Parvovirus-based vectors may thus be used for the transfer and targeted expression of therapeutic genes in cancer cells. b. STATE OF THE ART AND MAIN OBJECTIVES. Parvoviral genomes harbouring heterologous genes can be constructed and packaged into recombinant particles which are able to transduce these genes in target cells. Recombinants retain the oncotropic properties of wild-type parvoviruses in-vitro. Therefore,it is now important to determine whether they can target a toxic phenotype in tumour cells in vivo. The main restriction to this assessment lies in the low yields of recombinant parvoviruses produced by present packaging systems. Our purpose is to optimize, by combining different expertises in heterologous gene expression systems, the production and purification procedures so as to prepare stocks of recombinants which express cytokine genes and can be tested for their antineoplastic activity against model tumours in animals. c. EXPERIMENTAL APPROACH. The rodent parvoviruses MVM and H-l will be used, given their ability to grow in a wide variety of cells of both human and animal origin, and their apparent innocuousness for humans. Genomic infectious clones of these viruses proved to be suitable for the insertion, transduction and expression of foreign genes. - Construction of chimeric and second generation parvoviral vectors. Three approaches will be followed. (i) To boost the production of recombinants, known replication/ excision-promoting elements of parvoviral DNA will be incorporated into the parvoviral vectors. (ii) Chimeric adenovirus and retrovirus-based vector
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generation and Evaluation of ""Next-generation"" Antibody-Toxin-Conjugates for Cancer Therapy""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Therapeutic antibodies have transformed cancer therapy during the last decade, due to their high selectivity of targeting cancer cells in comparison to standard small molecule chemotherapy. Most recently, the coupling of cellular toxins to therapeutic antibodies has demonstrated an even greater efficacy in the therapy of cancer and the first, highly potent antibody drug conjugate (ADC), Adcetris®, was FDA approved in August 2011.All ADCs currently in clinical development are generated by chemical conjugation of small molecule toxins to antibodies. This is an inefficient process, as site and ratio of toxin coupling cannot be controlled. In addition, the chemical conjugation involves chemical modification of potentially functional parts of the antibody. This can have negative effects on stability, specificity, CMC properties and the overall structure of the antibody. All this renders ADC manufacturing highly challenging, complicates regulatory procedures, and adds to development time and costs.The SME consortium has complementary proprietary technologies and proposes to leverage this complementary expertise and know-how for defining novel processes of enzymatically conjugating small molecule toxins to antibodies that allow full control about toxin coupling site and ratio. Due to the high selectivity of enzymatic conjugation and physiologic conjugation conditions, it is expected that more homogeneous ADCs are generated with better CMC properties, higher potency, and at lower cost-of-goods in manufacturing. The consortium members believe that this represents a disruptive technology that will be highly competitive to traditional chemical conjugation, currently dominated by U.S.-based ADC technology companies Seattle Genetics and Immunogen. In addition to novel composition-of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'IMPROVING GENERIC AND PROFESSIONAL COMMUNICATION OF DOCTORAL GRADUATES ACROSS EUROPE', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

ProComDoc is presented by Pierre and Marie Curie University (UPMC) (coordinator) and University of Granada (partner) on behalf of seven other universities, all of them belonging to EUA Doctoral Programme Network 1. UEA conclusions show that, besides the s cientific ones, doctoral students (should) acquire generic and professional skills through their doctoral studies. But they rarely know how to communicate on them. To fill this gap we propose to entrust the organisation of events to doctorate teams intende d to communicate to a large public on the added value of training by research in conformance with the Initiative Objectives. We want to convince recruiters that doctors can handle project management in any professional, intercultural, intermanagerial frame work. We want to convince young students that doctoral training is worth considering, not only for research but also for mana- gement careers. To help doctorate teams to manage these events, we propose them an additional training on com- munication ski lls and on the subjects adressed by the communication process. To design a methodology for conducting such actions, we will analyse (SWOT) the whole project. First, the nine universities constitute doctorate teams and prepare these events (Months 1-4). Sec ond, in Month 5, five delegates of each team will attend a doctorate seminar, co-organized by the University of Granada and UPMC. They will defend their project and be trained on communication, according to cultural and managerial specificities of European countries. Delegates will have to share there gained communication skills with their team during the completion of the preparation of the local event, giving a snowball effect to the Granada school (Months 5-7). Third, a debriefing meeting (Month 7) will be organ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Research Conference on Challenges in Granular Physics""'.

assistant: **Innovation**

The field of granular physics is almost unique in its marriage of the most fundamental statistical and nonlinear physics with decades of engineering practice. While the fundamental solid mechanics and flow mechanics of grains seems akin to a variety of engineering problems in elasticity and, rheology, the disordered nature of these systems creates problems that can only be solved by powerful methods of statistical physics. In addition, many of the problems of geophysical interest have traditionally been addressed by geophysicists and sedimentologists. Thus the expertise that contributes to this field ranges from engineering contact mechanics to theories of glassy dynamics, relaxation, and aging. This dialogue between science and engineering must be nurtured to assure continued progress in this rapidly developing field. In addition, there must be dialogue among the different areas of physics (glass theory, nonlinear dynamics, fluid dynamics), which have contributed significantly to this progress over the last ten years.We have organized a conference made up of seven plenary sessions, covering such diverse areas of granular physics as Dry Flows and Avalanches, Wet Flows, Computational Methods, Kinetic Theory, Granular Statics, Compaction and Vibration, and Glassy Dynamics. Keynote talks will be given by three internationally recognized leaders in theoretical and experimental physics, and we have assured the participation of many eminent senior and mid-career scientists and engineers working in this field, from across the developed and developing worlds. Granular physics is important in a variety of applications in the petroleum and pharmaceutical industries, as well as in the management of natural hazards. At the same time, it represents one of the most ideologically prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synthesis of new materials based on half metallic ferromagnet CrO2 and optimisation of its properties for spin-electronics', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The search for new materials as an alternative to Si-based technology has been at the forefront of research in contemporary solid-state physics and chemistry. One interesting route of overcoming the restrictions of conventional electronics is to make use o f the spin to transfer information.A perquisite for this is the use of materials with full spin polarization of the conduction electrons such as the half metallic room temperature ferromagnet CrO2. We propose an investigation of high purity samples of CrO 2, which have been recently synthesized using a novel route.These samples with a hitherto unexplored crystallographic and magnetic microstructure exhibit a host of interesting properties, together with the first observation of finite room temperature magnetoresistance (MR). We have also prepared some new CrO2 based composites, which exhibit significant enhancement in MR and thus can be used as potential candidates for spintronic devices.Since this technique opens a new way to tailor MR by introducing new types of grain boundaries in any desired mass fraction, this provides a way to optimize parameters for spintronic properties of CrO2 based materials. We intend to study the effect of variation of the grain size and grain boundary density, in particular the r ole of antiferromagnetic nature of the grain boundary in magnetotransport.Besides magnetic and transport measurements in ultra high fields up to 60 Tesla, we propose to use a variety of complementary techniques such as specific heat in magnetic field, Hal l effect, thermopower and electron spin resonance.Better understanding of the underlying physics from the analysis of data obtained from these experiments will enable us to optimize parameters for a practical room temperature spintronic device based on Cr O2.Fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Platform Level Bureaucracy and Social Inclusion' (PERSON), addressing dissemination and exploitation.

assistant: **Impact**

PERSON - Platform Level Bureaucracy and Social InclusionPERSON analyses what happens to the bureaucratic encounter and to street level bureaucrats’ (SLBs) discretion when access to service becomes digital. Studying the use of three platforms for accessing Job Centres activated in Italy (DID Platform), Canada (Québec.ca Platform), and the Netherlands (UWV Platform), PERSON investigates the way in which digital bureaucratic encounters affect SLBs’ discretion and aims to develop guidelines for an inclusive public platform design, overcoming barriers related to gender, age, and ethnicity.The core idea revolves around how digital practices change not only the way SLBs use their discretion, but also the very nature of the bureaucratic encounter between users and SLBs, consequently, it appears necessary to investigate the relationship between these two actors, mediated by digital public platforms.The research will be conducted in three countries with three different levels of digitisation of the public sector, through the implementation of creative and replicable tools for digital qualitative research (Digital Subsystem Technique; Vignette Techinque for Internet Based Research).PERSON wants to understand whether the digital bureaucratic encounter amplifies or reduces the effects of the characteristics of the actors (SLBs and users) on the actual access to the public service. The final objective is to develop guidelines to design an inclusive platform for the public sector by comparing similar platforms in three different digitisation contexts.


**Keywords:** street level bureaucracy,  bureaucratic encounter,  digitalization of public sector,  public administration,  social inclusion,  public platform,  qualitative research,  vignette,  gender studies,  sts studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Long chain diols as novel organic proxies for paleoclimate reconstructions' under Seventh Framework.

assistant: **Concept**

Accurate reconstructions of past climate changes are essential to understand e.g. the sensitivity of Earth’s climate to global increases in atmospheric greenhouse gasses such as CO2. For these reconstructions it is vital to have proxies which are well constrained and are able to provide robust quantitative estimates. However, it has become clear that currently used proxies are sometimes associated with large uncertainties and thus more proxies are needed in order to perform reliable paleoclimate reconstructions.In my group we are developing new proxies based on so-called long chain diols. These compounds are synthesized by several groups of algae and occur abundantly in present day oceans as well as ancient sediments. Initial results have shown that one set of compounds, the 1,14-diols, can be used to reconstruct past primary productivity and upwelling conditions. Excitingly, the distribution of another set of compounds, the long chain 1,13- and 1,15-diols, show a strong relationship with sea surface temperature and can be used to reconstruct past sea surface temperatures in several parts of the oceans. Finally, culture experiments indicate that the stable carbon isotopic composition of diatoms producing 1,14-diols is strongly related to CO2 concentrations, raising the possibility that it may be used to reconstruct ancient pCO2 levels.In this ERC proposal I want to develop, test and apply these exciting new proxies in order to provide robust and accurate reconstructions of past oceans. To this end this ERC project is subdivided in several different subprojects, each designed to investigate long chain diol proxies but from a different perspective, in particular cultivation and molecular biology, organic geochemistry, (paleo)limnology and paleoceanography. The combination
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Role of SMAD4-mediated BMP Signal Transduction in Determination of Digit Identities, Initiation of Chondrogenesis, and Skeletal Development' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The limb bud is a system of paradigmatic value to analyze vertebrate organogenesis. One major question is when and how the chondrogenic progenitors of the limb skeleton are determined.  Recent studies suggest that digit identities are only fixed during advanced autopod development by BMP signal transduction. Here, I propose an in-depth analysis of the underlying signaling systems using mouse limb buds to gain insight into the requirement of Smad4-dependent and independent BMP signaling for chondrogenesis. Furthermore, the relevance of these findings to engineering cartilage   and bone from adult mesenchymal stem cells will also be investigated, which is of significant biomedical relevance towards efforts to improve human health.Aim 1. BMP signaling in determination of digit identities and chondrogenesis. These processes are disrupted in Smad4 deficient mouse limb buds. Therefore, I will study the cellular and molecular alterations of Smad4-/- in comparison to other mutant and wild-type limb bud mesenchymal cells.Aim 2. Identification and functional analysis of the molecular networks controlling Sox9 expressing digit progenitors. The transcriptomes of digit and interdigit mesenchymal regions of wild-type and mutant autopods will be analyzed. Such identified candidate regulators will be investigated further to identify the networks governing determination of Sox9 expressing digit progenitor cells.Aim 3. The potential relevance for adult skeletal repair and engineering of cartilage and bone tissue from mesenchymal stem cells.  Comparative molecular and functional analysis to provide insights into the similarities of limb bud and adult mesenchymal stem cells.