RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conserved and divergent mechanisms underlying cytokinesis in early vertebrate and invertebrate embryogenesis' under Horizon Europe.

assistant: **Concept**

Cell division is the fundamental process for cell differentiation and tissue formation in early embryogenesis. Mainly depending on the distribution and amount of yolk, fertilized embryos undergo holoblastic and meroblastic divisions. Holoblastic division can be found in most mammalian embryos including mouse embryo, in which actomyosin forms contractile cytoskeletal ring and divides the zygote into two daughter cells. In contrast, cell division in fish and insect embryos, such as zebrafish and Drosophila embryos, are meroblastic, and accumulating evidence shows that actomyosin is dispensable for meroblastic furrow ingression. Meanwhile, microtubule has been suggested to constitute the main component that drive meroblastic furrow ingression. How microtubule functions in furrow ingression of meroblastic cleavages in zebrafish and Drosophila embryos, and how far those functions are conserved between these species, remain to be fully understood. The MiMING project aims to uncover the role of microtubule and associated motor proteins in meroblastic furrow ingression in zebrafish and Drosophila, which fits me very well, as I have abundant knowledge about functions of cytoskeleton in embryogenesis and biochemical experimental methods in checking the function of actomyosin and microtubules on the cortex of Drosophila embryos in syncytial and cellularization stages from my PhD study and follow-up work. To check the biochemical and biomechanical mechanisms in meroblastic furrow ingression of zebrafish and Drosophila embryos, I would like to join Prof. Carl-Philipp Heisenberg lab at the Institute of Science and Technology Austria (ISTA). Prof. Heisenberg is a world-renowned developmental biologist (high citation publications > 80, total citations > 26670), who has pioneered interd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing Green Long-life Roadways: Unveiling the Fatigue and Durability Behaviour of Sustainable Fiber-Reinforced Recycled Asphalt' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Asphalt recycling is globally important for its environmental and economic benefits, including reduced CO2 emissions, conservation of natural resources, and cost savings. The growing demand for sustainable solutions has accelerated the adoption of reclaimed asphalt (RA) recycling techniques, promoting a circular economy and supporting the EU's 2050 Climate Neutrality goals. Ensuring durability and service life is crucial for efficient RA recycling, but the complex components in recycled mixtures pose challenges. Fiber-Reinforced Recycled Asphalt (FRRA) has emerged to address these challenges, yet current research largely focuses on experimental mechanics, leaving fatigue debonding mechanisms insufficiently understood. Factors such as material type, construction conditions, and environmental impacts complicate fatigue behaviour analysis. Bridging the gap in understanding long-term performance is vital for optimizing FRRA materials. The MSCA-GOLFatDue project aims to tackle these challenges through innovative research in four areas: (1) investigating material interaction mechanisms and their impact on fatigue debonding, (2) developing a trans-scale computational model for accurate fatigue life prediction, (3) creating a validated evaluation protocol for optimizing FRRA compositions and structures, and (4) developing new sustainable, durable recycled asphalt materials for industrial applications. The GOLFatDue project enables Dr. Ren to explore the fatigue and durability of FRRA materials by combining fundamental scientific research at three prestigious European universities (University of Antwerp, University of Nottingham, and University of Lyon) with industrial applications. This project will advance European research on green infrastructures and sustainable construction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Researchers’ Night 2012 in the Czech Republic:' (RN2012CZ).

assistant: **Concept**

The concept of Researchers' Night 2012 is based on the performance of scientists as ordinary people who are in essence no different from the general public. The goal is to bring together the public at large and researchers to improve the image of researchers and to strengthen the public recognition in the scientific work in a funny way. The next goal is to stimulate young people's interest in scientific careers through this event. This year's motto is ""Science does not age."" It reflects the organizers' efforts to alert the public to the permanent value of scientific knowledge. Scientific research is universal and timeless. A massive amount of new information of many kinds appears every day but may quickly become outdated. On the other hand, factual approved findings which scientists have invented across the generations push the boundaries of our understanding of the world into new dimensions. During the Night, the public at large from all regions of the Czech Republic will have the opportunity to explore the scientific work, have fun and share their leisure time with the scientists. Anyone regardless of age and scientific skills will be able to participate in experiments, watch demonstrations, take part in competitions or just enjoy having fun with researchers. The role of the European Commission in supporting this particular event will be described and the EC will be presented as an institution that continuously and largely supports research Europe-wide.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analytic Techniques for Geometric and Functional Inequalities' (ANTEGEFI).

assistant: **Concept**

Isoperimetric and Sobolev inequalities are the best known examples of geometric-functional inequalities. In recent years the PI and collaborators have obtained new and sharp quantitative versions of these and other important related inequalities. These results have been obtained by the combined use of classical symmetrization methods, new tools coming from mass transportation theory, deep geometric measure tools and ad hoc symmetrizations. The objective of this project is to further develop thes techniques in order to get: sharp quantitative versions of Faber-Krahn inequality, Gaussian isoperimetric inequality, Brunn-Minkowski inequality, Poincaré and Sobolev logarithm inequalities; sharp decay rates for the quantitative Sobolev inequalities and Polya-Szegö inequality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '4FOLD Reduction of the International Transport of Empty Containers by Folding' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Due to the global imbalance of import and export ca. € 25 billion a year is spent on repositioning empty containers, and unnecessary emissions of CO2 , NOx and PM are generated. The technical solution proposed by Holland Container Innovation Nederlands (HCI) for this economical and environmental problem is the 4FOLD foldable container. This concept is IP protected by HCI by 8 patents. 4 folded 4FOLD containers stacked upon each other have the same dimensions as one empty container, thus enabling the reduction of the number of transport movements by up to 75%. This proposal fits within the topic “IT.1-2014-2015. Small business innovation research for Transport” of the work programme “Smart Green and Integrated Transport”. The 4FOLD container strengthens the European transport sector by making container transport more time and cost efficient, creating new jobs, and tackling the aforementioned environmental and mobility defies.Currently, the 4FOLD container of HCI is the first 40ft foldable container in the world that has received both the CSC and ISO certifications. This prototype is at TRL7 as it is being demonstrated in an operational environment in 3 small international pilot projects. In this project the technical feasibility of commercial production is assessed, the environmental and financial benefits are quantified in a model, a partner search for a demonstration project with 500 – 1,000 4FOLD containers is conducted and the preliminary business plan is elaborated by including a market implementation roadmap.The long term ambition of HCI is complete replacement of the conventional 40ft container for the transport of freight on sea, rail and road, starting with the introduction of 200,000 4FOLD containers before 2020. Key parameters in HCIs business proposition are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ONCOlogic patient profiling and personalized treatment through SMART bedside diagnostics' (Oncosmart) under Horizon 2020.

assistant: **Objectives**

The advent of personalized cancer care demands for distributed diagnostic solutions to support clinical decisions and selection of the best therapeutic regimen. Supportive information can be obtained by analyzing the response of patient’s tissue to various treatment options. A specific opportunity arises in the field of cellular analysis, where the ex-vivo assessment of drug efficacy performed through drug response assays represents a powerful tool and, at the same time, a challenge due to the difficulty of maintaining in-vitro conditions that closely resemble in-vivo cell response. CellPly developed a novel in-vitro diagnostic (IVD) product to define cell response to anti-cancer drug treatment through integrated drug response analyses. Oncosmart platform includes a smart consumable, integrating a hybrid polymer/flexible-PCB micro-technology, an analytical instrument and diagnostic software.After patient’s tissue sampling, an automated process will carry out sample preparation, precise drug delivery and monitoring of cell response through time-lapse imaging. Cancer patients will benefit from more personalized cancer therapies, while the public health systems will reduce overall analysis and hospitalization costs and better allocate resources dedicated to cancer therapies. The Phase 1 project will set up the a quality-certified manufacturing chain and plan the validation of the platform in clinical setting in the field of acute leukemia; regulatory pathways to comply with CE-IVD and to seek reimbursement will be assessed; the commercialization strategy and associated business model(s) will be elaborated.


**Keywords:** Microfluidics, Lab-on-a-chip, Diagnostics, Point-of-care, Personalized Medicine, Predictive , Oncology, medical device, healthcare, cancer, leukemia, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimization of Hydrogen Storage via Spillover through a Combined Experimental and Modeling Approach' (HSpill-CEMA).

assistant: **Concept**

The objective of the proposed work is to synthesize catalyzed nanoporous materials that have superior hydrogen uptake between 300K and 400K and moderate pressures (20-100 bar) via the hydrogen spillover mechanism. Hydrogen spillover involves addition of a catalyst to a high-surface area microporous support, such that the catalyst acts as a source for atomic hydrogen, the atomic hydrogen diffuses from the catalyst to the support, and ideally, the support provides a high number of tailored surface binding sites to maximize the number of atomic hydrogens interacting with the surface.  The proposed work will provide a means to explore an extended collaboration to combine in situ spectroscopic techniques and theoretical multi-scale modeling calculations. Carbon-based and microporous metal-organic framework (MMOF) materials will be drawn from past and on-going projects, so that the project will focus on identifying specific binding sites for atomic hydrogen and resolving the hydrogen spillover mechanism. Materials will be selected to explore the effect of catalyst size, material composition and structure, interface, and the potential role of co-catalysts on optimizing uptake via the hydrogen spillover mechanism.  Materials will be characterized with in situ spectroscopy, and multi-scale modeling will be used to identify hydrogenation sites.  Validated theory will be used to direct future material development. Identification of the key sites responsible for high uptake in select materials is expected to lead significant increase in capacity and reproducibility in hydrogen spillover materials that are optimized for near-ambient temperature adsorption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Metastability of proteins during tumor metastasis' (METAMETA), addressing dissemination and exploitation.

assistant: **Impact**

Mutational heterogeneity bestows tumors with the phenotypic plasticity and adaptability required for expansion. On the other hand, mutations destabilize proteins – lower stability (metastability) of the tumor proteome must be the inevitable consequence. We set out to systematically investigate this biochemical aspect of metastasis aiming to uncover and therapeutically exploit specific vulnerabilities resulting from protein destabilization. We will approach this goal by cataloging associations between metastasis-promoting proteins and molecular chaperones. Chaperones are obvious candidates to stabilize the proteome, therefore we will prepare a BAC-based mouse model of metastasis, where the contribution of 63 chaperones, comprising the entire murine HSP70 superfamily, to metastasis development will be individually investigated. The role of metastasis-relevant chaperones at the molecular level will be elucidated using mass spectrometry, complemented by next-generation sequencing of metastatic exome. In parallel, a novel proteomics-based method to evaluate aberrant complex formation in tumor cells will be established.Because of the high heterogeneity of cancer, molecularly tailored and combined therapies are needed. To this end, we will capitalize on insights regarding the role of chaperones in metastasis by identifying proteasomal degradation activators able to support or replace the activity of individual chaperones from the HSP70 superfamily. Finally, we will validate the potential of combined, yet specific manipulation of the folding and degradation machineries to suppress metastasis development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding outer membrane protein biogenesis in Bacteroidota bacteria' (BactOMPbuild), addressing dissemination and exploitation.

assistant: **Impact**

Gram-negative bacteria are distinguished by the presence of an outer membrane (OM) at the cell periphery. This membrane is the site at which the bacterium interacts with its environment (or host if a pathogen), and provides the first line of defence against antibiotics, mechanical stresses, and immunological attacks. These functions depend on the presence of proteins that either span the outer membrane (Outer Membrane Proteins, or OMPs) or are anchored to the membrane by a lipid tail (lipoproteins). Sophisticated machinery is required to target, insert, and fold these proteins. Although this machinery is well-characterised in Escherichia coli and related organisms, it remains unclear how OM proteins are assembled in other major Gram-negative phyla.    In this project we aim to elucidate novel features of OM protein biogenesis in bacteria of the phylum Bacteroidota (formerly Bacteroidetes). The Bacteriodota are key human commensals, but also include major anaerobic pathogens, and are environmentally abundant. The pathways for OM protein biogenesis in the Bacteroidota differ from the E. coli paradigm in at least two major ways that we will investigate.   First, we have discovered that the Bam complex that is responsible for inserting OMPs into the OM has a very different composition from the E. coli paradigm and includes novel extracellular subunits. We now seek to identify the function(s) of these additional subunits and elucidate their molecular mechanism.    Second, in contrast to E. coli, the cell surface of Bacteroidota bacteria is coated with abundant lipoproteins (surface lipoproteins, or SLPs) that must be exported across the OM by a currently unknown mechanism. We aim to identify and characterise this SLP transporter as well as the novel pathway that our work has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Self-Assembly: Shifting our View of Life' (AssemblingLife), addressing dissemination and exploitation.

assistant: **Impact**

Biology invites us to understand life as “hard work”. Living beings are mainly viewed as systems requiring the constant input of energy and the detailed regulation by genetic material. These ideas of life very much influence the general understanding of living systems, and, particularly interesting for this project, it influences current philosophy of science accounts of the understanding and explanation of living processes. But what if life is much less “hard work” than often presented? And what if genes should be understood as “nudgers” rather than as “directing” living processes? Self-assembly is the spontaneous formation of complex patterns and structure. It can be visualized as a pile of lego bricks turning into a Ninjago fortress on its own. There are no lego-builders. The parts “self-assemble”, possibly as a result of chemical and physical processes working between and on the parts. Recent nanoscience research efforts at the intersection of chemistry, biology, and material science, increasingly utilize self-assembly processes in the development of new materials, technologies and understanding of living systems.AssemblingLife will, on an interdisciplinary basis, build a new theoretical framework withing the philosophy of science for understanding and explaining life, building on the increasing focus and knowledge about self-assembly processes that carry the potential to shift our view of life. The project will provide a new understanding of genetic causation starting from the idea of genes as “nudging” self-assembly processes rather than as providing detailed regulation, and it will develop new theory of scientific explanation that will account for the observation that self-assembly processes do not behave like classical mechanisms or interventions targets. Assemb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CMB Lensing at Sub-Percent Precision: A New Probe of Cosmology and Fundamental Physics'.

assistant: **Concept**

Maps of the gravitational lensing of the cosmic microwave background (CMB) directly trace the mass distribution across our universe. Though recent measurements have established the CMB lensing signal as a powerful probe of cosmology and fundamental physics, we are only beginning to exploit its scientific potential. My ERC-funded team will analyse lensing in CMB data from Advanced ACTPol and Simons Observatory, powerful ground-based experiments for which I am co-leading the lensing working groups. By developing and applying new analysis methods, my team will reconstruct large-sky CMB lensing maps that are an order of magnitude more precise than current state-of-the-art measurements.With our high-fidelity lensing maps, we will address key questions about the origin of the universe, the properties of neutrinos, the nature of dark energy, and the formation of cosmic structure. We will determine or tightly bound the unknown neutrino mass by measuring the CMB lensing power spectrum to 0.6% precision, place stringent constraints on the time evolution of dark energy by combining CMB lensing maps with large-scale structure datasets, and enable powerful searches for primordial gravitational waves by removing the limiting lensing signal from the CMB polarization. To achieve these goals, my group will address the central challenges posed by the advance of lensing science to ultra-high precision, pioneering new approaches to lensing estimation, foreground mitigation, and CMB B-mode delensing.