RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Energy Software Tools for Sustainable Machine Design' in the context of a Seventh Framework call.

assistant: **Objectives**

This project addresses all production machine sectors (e.g. machine tools, agricultural machines, textile machines). Design approaches for these machines, which are currently performance and capacity driven, have to evolve to approaches where resource efficiency is optimized. To do so, energy efficiency has to be taken into account as a key parameter in the design process.<br/>The main goal of the ESTOMAD project is to develop a methodology and related ICT tools to model, simulate, analyze and optimize energy flows and losses throughout the whole machine. When optimising machine designs, interaction with suppliers is indispensable for getting up-to-date component data. Supporting this interaction is therefore a key aspect of the ESTOMAD goals. To guarantee quick take-up, the methodology will be embedded in an existing, widely used machine design software.<br/>Starting from a methodology specification, developments will be made towards multi-domain energy descriptions on different levels. In parallel, a framework will be developed for machine designers to interact with their supplier on energy considerations. Specific tests and measurements will be conducted on a number of benchmarks for verification purposes. Availability of these benchmarks allows for an extended dissemination of project results to the wide machine production sector. After embedding the ESTOMAD methodology on the existing software a number of demonstrators will be realized.<br/>The methodology will constitute a useful base for realizing regulations on energy consumption that are under development for many products, including production machinery (EUP directive).<br/>Realizing these goals requires a multi-disciplinary team with strong industrial involvement from various applications. The team is compose
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High Power Charger For Electric Vehicles' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Electric vehicles (EVs) hold the key to environmentally friendly transport for the future, but they are on an environmental and technological detour: Owners buy fuel cars because of range anxiety and charging typically takes hours, not minutes.Nerve Smart Systems has invented and patented the B-HPC (Buffer-High Power Charger). The battery and control system of the B-HPC enables delivery of ultra-fast-charging power (350 kW) by using low-power grid connections. The B-HPC can charge a vehicle in the same time as it takes to fuel a conventional car, and with benefits such as significantly lower initial grid installation costs, low stress on grid and low total cost of ownership, the B-HPC is the missing link for a large-scale roll-out of EVs.The B-HPC will be 30% cheaper than current state-of-the-art fast chargers today, increasing to 44% cheaper by 2023, as it scales better with large volume manufacturing. As it also performs better it will be an attractive choice when approx. 25 million chargers will be put out in Europe alone in the coming years (market value approx. €600bn). Through own label and particularly license agreements, Nerve Smart Systems foresees a revenue of €500m globally in six years’ time.The objectives of the project are to build and test a 350kW High Power Charger, demonstrate fully working systems that can be used as pre-marketing for later sales, and ensure scalability of both technology and business to prepare for roll-out to international markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ras Genes in Health and Disease' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Ras genes are some of the best-studied genes in biomedical research due to their central role in mitogenic signaling and their oncogenic activation in one third of all human tumors. More recently, Ras genes have also been implicated in developmental disorders including Costello and Noonan syndromes. In spite of this wealth of information, we still do not know the role of Ras proteins in adult homeostasis and, more importantly, how their misregulation affects human health. The latter is of paramount importance in order to develop efficacious therapies against tumors carrying Ras oncogenes - an achievement that could save thousands of lives worldwide. We propose to address these issues using genetic approaches in mouse models. We aim to systemically ablate all Ras genes in adult mice as well as in selective tissues to understand their role in normal homeostasis. We also propose to characterize mouse models for developmental disorders induced by hyperactive Ras proteins. These models should help us to better understand these human disorders as well as tools to test potential therapeutic strategies. Finally, we propose to use K-Ras driven mouse tumor models for human PDA and NSCLC to address key questions that may be directly translated to the clinic. In the case of PDA, we propose to study the contribution of the inflammatory response induced by pancreatitis to tumor development. In the case of NCSLC, we propose to isolate cancer initiating cells in an attempt to reveal the earliest events in tumor development. Moreover, we intend to use this tumor model to validate druggable Ras downstream effectors as therapeutic targets. The results derived from these studies should provide key information to design forthcoming clinical trials that will benefit cancer patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Point-of-care tests to revolutionise the clinical management of patients infected by Hepatitis C virus' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Point-of-care (PoC) medical devices have the potential to revolutionise clinical practice. SMEs within our Consortium (Epistem & Biosurfit) have developed genetic and protein PoC devices to deliver on this promise. Results from these enabling technologies will be integrated using novel bioinformatics tools and algorithms (Qlucore) allowing for bed-side analysis. This integrated genetic-protein approach will exploit recent biomarker discoveries from the FP7 project SPHINX, to improve  the management of hepatitis C virus (HCV) infected patients. We will focus on two public health problems: (i) addressing the need to predict, pre-treatment, individuals in resource poor countries (e.g. Egypt) who will benefit from conventional treatment; and (ii) helping to limit treatment costs globally, where new therapies for HCV are anticipated to significantly increase health care expenditures. The predicitve biomarkers are ready for immediate implementation and will greatly improve HCV patient management issues such as decision to treat, selection of therapy, and response-guided monitoring. The predictive power of the SPHINX biomarkers are reliant upon the combination of genetic and protein data. Highlighting the innovative aspect of our proposed work, no clinical algorithms have taken advantage of such a combined genetic / protein biomarker approach for diagnostic tests. To realise this vision, Qlucore will establish patient population-based algorithms that integrate the PoC data on a mobile application, thus facilitating immediate interpretation by physicians. Together, our Consortium will boost prior FP7 discoveries and deliver an integrated platform for predictive and prognostic applications. The associated SMEs will expand their portfolio, but more importantly, our consortium wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Diversity Generating Retroelements – Understanding a New Class of Mobile RNAs' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Retroelements are genetic elements that use reverse transcriptase to insert DNA copies of their RNA into new locations in the host genome. They are found in all realms of life and are one of the major agents shaping genomes. A newly discovered class of viral and bacterial retroelements, the diversity-generating retroelements (DGRs), have the unusual ability to repeatedly target and mutagenize a defined region of the host genome. This process is conceptually similar to the antibody diversification process of the immune system, but has developed independently and thus employs an entirely different mechanism. The proposed project seeks to elucidate several aspects of DGR function in order to deepen our understanding of this novel mutagenic mechanism and evaluate its implications and applications in such diverse fields as biotechnology, medicine, evolution and immunology. The first major aim will be the development of a fluorescence-based in vivo assay system for DGR activity. This will speed up the experimental read-out drastically and allow for systematic screening to identify crucial components of the mutagenic mechanism. In parallel, the molecular components of DGR elements will be characterised in the second research aim. The reverse transcriptase protein and the RNA template will be investigated using biochemical, biophysical and structural methods. Many components of this proposal draw heavily on my postdoctoral experience, while other parts require co-operation with groups at the host university and European research institutes. Moreover, through teaching at university level, I will be able to train young researchers and expose them to cutting-edge research. Taken together, the proposed project thus leads to knowledge transfer into the European Union, long-term re-i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Brain stimulation of attention networks: examining old principles and developing new clinical applications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Attentional deficits are a frequent consequence of brain damage after stroke. Current treatment approaches using brain stimulation techniques such as transcranial magnetic stimulation (TMS) are  based on two theoretical constructs, namely (1) inter-hemispheric inhibition within the dorsal attention network and (2) the presence of interactions between the ventral and dorsal attention network and. The proposed projects put these constructs to the test by combining TMS with neuroimaging and, based on these findings, explore novel brain connectivity based TMS treatments. Collectively, these projects advance current neurocognitive models of attentional control and lead to advanced TMS protocols that can alleviate attention deficits in patients.


**Keywords:** transcranial magnetic stimulation, positron emission tomography, functional magnetic resonance imaging, attention, hemineglect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Electrically driven DNA-origami-based machines' (EDRIVE).

assistant: **Concept**

Inspired both by Nature and the success of macroscopic machines, molecular engineers have been exploring various approaches for the realization of nanoscale artificial molecular machines (AMMs), i.e., molecular constructs capable of controlled mechanical actuation. Despite the great promise of AMMs and the tremendous progress in the field, especially on the synthesis side, multiple conceptual and technical challenges, and open questions, e.g., related to AMMs fabrication, implementation of actuation and, most important, AMMs functionality, still remain. Here, I will combine i) the DNA origami technique with its ability to construct well-defined complex three-dimensional nanostructures, and guide the assembly of functional nanoscale objects with unprecedented precision; and ii) electromechanical actuation, to build fast, remotely controlled artificial molecular machines with functionalities far beyond the state of the art. First, I will fabricate AMMs that translate external stimuli into well-defined spatial reconfiguration of metal nanostructures. I will use such AMMs to build i) active plasmonic surfaces with fast remote modulation of optical responses, and ii) plasmonics probes with single-molecule detection sensitivity. Second, I will design AMMs that can exert forces on single molecules; such AMMs will be used to fabricate i) nanoscale robotic arms, i.e., devices that can pick-up, transport and release cargo (molecules and/or nanoparticles) in multiple cycles, and ii) molecular motors, i.e., devices capable of performing useful chemical or mechanical work and driving chemical systems out of their intrinsic equilibrium. Fabrication of artificial nanoscale molecular motors has been a long-standing dream of molecular engineers.Results of this project will pave the way
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Herbicide Resistant Rice Development For European Continental Project'.

assistant: **Objectives**

Global rice production, so far, has been able to meet population demands. Rice production is considerable exposed to the environment and natural detrimental affect especially weed and weedy rice problems. Present herbicides are often suffered to kill weed and weedy rice that allows for more chemical usage and non-sustainable rice production system. Weed and weedy rice are a great problem because of resistancy and cultivation system such as direct seeded area, especially in Europe. In order to control the problem, Clearfield and Provisia technology developed in the United States. But some weed species or weed varieties are getting resistant to Clearfield rice in Europe in the last years. Thus, new alternative tools are needed for weed control.The main aim of the project is develop to non-GMO herbicide resistant new base rice for European countries. Herbicide resistant new base rice might be utilized control weed and weedy rice where gained resistance against to conventional rice herbicides in the fields. Project will investigate to develop non-GMO resistancy with Clethodim (Cyclohexanedione-Dim Group) herbicide resistance for rice. For this reason first objective is execute a mutation on rice seeds, second is develop to low and high resistancy on rice plant, the next objective is determination of mutation point on mutagen resistant rice. Last objective is investigated to deterioration of currently utilized herbicide resistancy system on especially the basis of IMIresistant red rice at incoming phase.The new resistancy system might be available to use when Clearfield and Provisia technology break down because of gene flow and misusage. The HerbaRice project will give new insights on weed and weedy rice problem on rice fields, providing new tools for herbicide resistancy p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sectoral Innovation Systems in Europe - Monitoring, Analysing Trends and Identifying Challenges' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The SYSTEMATIC project looks to provide policy-makers and stakeholders in the sectors with a comprehensive and holistic understanding of the sectoral innovation performance and challenges across the EU25. The fundamental question is to what extent and why innovation performance differs across sectors?The SYSTEMATIC project investigates the sectoral innovation performance in specific European sectors. Therefore, it plays a great role in developing new indicators and innovation models at sectoral level. Moreover, the SYSTEMATIC project goes beyond statistical analysis of cross-sector innovation performance and incorporates qualitative analysis. The project will also establish innovation panels composed of outstanding sectoral innovation specialists. They will serve as a platform for discussions on policy recommendations for each sector and steer and guide the entire project.In summary, the work is structured in 11 inter-linked workpackages:Sectoral Innovation Systems Scoping Papers; Mapping Sectoral Innovation Policies;Analysing & Modelling Sectoral Innovation Systems; Analysis and identification of Europe's sectoral innovation champions; Showcasing of Europe's sectoral innovation champions; Prospective vision of sectoral innovation challenges; Benchmarking National Sector Specific Environments; Analysis of regulatory and policy issues influencing sectoral innovation patterns; Identification of socio-cultural barriers and driving forces to innovation per sector; Organisation of Innovation Panels per sector; and Synthesis and presentation of all project results.Since sectors have highly specific characteristics, they must face specific issues that may require different policy responses. Consequently, the ultimate goal of the project is to identify main policy implications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'UniverSelf' in the context of a Seventh Framework call.

assistant: **Objectives**

The internet of today is fragmented into loosely interacting domains. Future Networks will be pervasive: people, machines and the surrounding spaces will form decentralized and dynamic networks of networks of as-yet unseen scales.  Future Networks will challenge Service and Network Operators to find the right ways to embed intelligence into networks in order to ensure their autonomic management and control.UniverSelf will consolidate autonomic methods of the future Internet for business-driven, service and network management into a novel Unified Management Framework (UMF) evolving through cognition. This UMF will remove the roadblocks of the original Internet design and of its later patchwork growth; it will seamlessly unite the control and management planes by enabling self-organisation of the former and empowering the latter with cognition. This will advance the routine management tasks by people to the level of governance of the entire network and service ecosystem.Innovative aspects of UniverSelf are: the dynamic and architecture-agnostic federation of intelligence; its network embodiment for optimum efficiency; technology maturation; processes for building confidence and trust. UniverSelf will convince Service and Network Operators that autonomicity becomes real when worked simultaneously from the two viewpoints - concept federation and network embedding.UniverSelf will adopt a use-case driven approach to develop high added value, innovative and cost efficient solutions that will serve both the EU economy and its Citizens, who will benefit in terms of QoE/QoS. The competitiveness of the European ICT industry will be significantly enhanced (creation of new business opportunities, reduced  time-to-market); standards bodies (ITU-T, ETSI and IETF) will benefit from Uni