RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A systems biology approach to RESOLVE the molecular pathology of two hallmarks of patients with metabolic syndrome and its co-morbidities; hypertriglyceridemia and low HDL-cholesterol' (RESOLVE).

assistant: **Concept**

Through combining basic pre-clinical and clinical research, network analysis and computational modelling, RESOLVE aims at resolving the disturbed dynamics and mechanisms underlying the high triglyceride (HTG) and low high-density lipoprotein cholesterol (HDL-C) phenotype and insulin resistance in patients with metabolic syndrome (MetS) and its associated co-morbidities (cardiovascular disease, CVD; type 2 diabetes, T2DM; non-alcoholic fatty liver disease, NAFLD). RESOLVE will deliver on 6 specific objectives:i) build a computational model for analyzing the kinetics of plasma lipids, lipoproteins and their interactions with glucose metabolism.ii) apply the iterative systems biology cycle for calibrating, validating and improving the computational model in dedicated studies in miceiii) build, calibrate and validate the computational model for use in humans.iv) analyze – based on model and experimental data – which processes in the murine metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interact.v) analyze – based on model and experimental data – which processes in the human metabolic network regulate the physiological response to perturbations in lipid, lipoprotein and glucose metabolism and how these interactvi) use the human model to identify network-based drug targets aimed at restoring the metabolic dyslipidemia and glycemic control in patients with MetS and associated comorbidities.RESOLVE 60-months project will result into a novel strategy for development of therapeutic strategies for MetS patients with T2DM, NAFLD or CVD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ETH Zurich Postdoctoral Fellowship Program 2', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ETH Zurich applies for a continuation of the COFUND support for its “ETH-Fellows” programme that received funding within the 2009 COFUND call. The programme supports incoming fellowships for postdoctoral researchers on a competitive basis. “ETH Fellows 2” aims at high-potential individuals primarily interested in following an academic career.  Awardees will be offered an ETH employment contract with a standard postdoctoral salary for two years and will be entitled to an annual individual travel and consumable budget.  Fellows are offered career development support and courses to develop their non-scientific skills. They are expected to take part in teaching activities of their host group and are encouraged to apply for additional competitive funding. The programme is open for all applicants who have obtained a doctorate from an institution other than ETH Zurich or the University of Zurich within 2 years of the date of application. The two-year rule can be waived in case of a career break. Applications are to be made jointly by the candidate and their host, who must be an ETH Professor and who will act as a supporter and mentor of the fellow.  No thematic restrictions apply and all research topics of interest to ETH Zurich are eligible for funding.  Proposals will be judged on the basis of scientific merit and the applicant’s track record by the ETH Research Commission and external reviewers.  “ETH Fellows 2” offers an excellent opportunity for young researchers to acquire new skills and competencies boosting their careers and helping to attain an independent senior position.  Support by COFUND together with an increase of ETH’s own contribution will significantly enhance the incoming mobility of advanced researchers from the EU States, Associated or Third countries to S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessing the Effects of Rising O2 on Biogeochemical Cycles: Integrated Laboratory Experiments and Numerical Simulations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The rise of atmospheric O2 ~2,500 million years ago is one of the most profound transitions in Earth's history. Yet, despite its central role in shaping Earth's surface environment, the cause for the rise of O2 remains poorly understood. Tight coupling between the O2 cycle and the biogeochemical cycles of redox-active elements, such as C, Fe and S, implies radical changes in these cycles before, during and after the rise of O2. These changes, too, are incompletely understood, but have left valuable information encoded in the geological record. This information has been qualitatively interpreted, leaving many aspects of the rise of O2, including its causes and constraints on ocean chemistry before and after it, topics of ongoing research and debate. Here, I outline a research program to address this fundamental question in geochemical Earth systems evolution. The inherently interdisciplinary program uniquely integrates laboratory experiments, numerical models, geological observations, and geochemical analyses. Laboratory experiments and geological observations will constrain unknown parameters of the early biogeochemical cycles, and, in combination with field studies, will validate and refine the use of paleoenvironmental proxies. The insight gained will be used to develop detailed models of the coupled biogeochemical cycles, which will themselves be used to quantitatively understand the events surrounding the rise of O2, and to illuminate the dynamics of elemental cycles in the early oceans.This program is expected to yield novel, quantitative insight into these important events in Earth history and to have a major impact on our understanding of early ocean chemistry and the rise of O2. An ERC Starting Grant will enable me to use the excellent experimental and computati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Disrupting the real-time medical imaging market, and accelerating innovation, with cloud Platform as a Service (PaaS)' (PaaS).

assistant: **Concept**

Medical imaging science has progressed greatly in recent years with advances in cloud computing power, computer vision, machine learning and augmented reality. There is global political will to improve the efficiency of healthcare delivery through better exploitation of information technology. But there is surprisingly little translation of research output into clinical systems supporting real-time imaging. Large hardware manufacturers currently dominate the software market for image-guided surgery. Their business model is based on high capital expenditure for installing large equipment that combines hardware and software. But this model means high costs and long lead times for changes, creating high barriers to innovation.Cydar has identified an opportunity to disrupt this model by decoupling software innovation from the hardware. The concept is a dedicated cloud platform that hosts third-party applications, while handling image anonymisation, information security, governance and data storage. The core, tested technology involves a standard PC and web browser securely streaming the live imaging in the operating room to the cloud platform. This business model is cloud Platform as a Service (PaaS), hosting applications for enterprises, healthcare organisations and academic institutions. Revenue streams include hosting fees and fees for access to the stored data for secondary use.Crucially, end-user markets become widely accessible, costs are lowered, lead times slashed and the commercial risks of innovation reduced. The model is readily scalable for the global market. We expect it to accelerate the exploitation of medical digital data for the benefit of citizens, both as patients and as taxpayers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Collective Phenomena in dense Active Matter: phase transitions and non-equilibrium dynamics.'.

assistant: **Concept**

The overall aim of the research activities presented in this proposal is to elucidate the general principles governing the physics of many-body systems of active particles when excluded-volume interactions compete with internal driving forces. We aim to reach a general understanding of this novel class of “active materials” and give an answer to the following question: How are the structure of the liquid and solid phases, and their mechanical response to an applied deformation, affected by self-propulsion? Statistical mechanics can efficiently deal with a broad class of soft matter systems at thermal equilibrium. However, active matter evolves in a non-equilibrium manner, as it is made of elements which have their own source of motion, which demands a new conceptual framework to describe it. By combining numerical simulations and theoretical analysis of model systems, we intend to get new quantitative predictions that can be tested experimentally in suspensions of self-propelled colloids, active emulsions or dense assemblies of cells, and exploit our results to design and characterise novel materials through collaboration with experimental groups. The completion of this programme will represent a major contribution into this fast-growing field with direct applications in materials science and biophysics: the engineering of synthetic materials that mimic the behaviour of living matter is a major challenge of current science and technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unraveling the Mysteries of Vibrational Strong Coupling' to be submitted under Horizon Europe.

assistant: **Abstract**

Polaritonic Chemistry is a new and exciting field that has emerged from the fusion of chemistry and cavity quantum electrodynamics. In this innovative realm, and specifically under Vibrational Strong Coupling (VSC), hybridizing molecular vibrations with electromagnetic cavity modes has been shown to modify the rate and yield of reactions, solvent polarity and other molecular properties, in the absence of any illumination. The prospects for VSC as a versatile tool for chemistry and materials science have sparked a worldwide surge of interest, leading to substantial advances in recent years. Nevertheless, deciphering the underlying mechanisms by which VSC affects material properties still poses formidable challenges, impeding the utilization of VSC to its full potential. The goal of UnMySt is to construct a complete framework for cavity-controlled chemistry, built upon a comprehensive mechanistic understanding of VSC on both the molecular and supramolecular levels. As leading scientists in the field, we will pursue this goal by joining our forces in seeking answers to these pivotal questions: 1. What is the mechanism that links the local character of molecular reactivity with the collective nature of VSC?2. Do the thermal equilibrium properties of materials change under VSC and how are such modifications expressed in polaritonic chemistry?3. What are the manifestations of VSC on non-equilibrium dynamics such as solvent reorganization or charge transfer?4. Can symmetry considerations provide intuitive guidelines for cavity-controlled chemistry? Can symmetries imposed or broken by the cavity be used to tailor its impact on reactivity? Our synergistic experimental and theoretical efforts will reveal novel physical mechanisms and will lay the qualitative and quantitative foun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Beyond hyperelasticity: a virgin land of extreme materials'.

assistant: **Innovation**

Beyond bifurcation, beyond instability, beyond even hyper-elasticity (!) there is an unexplored world of superior materials, capable of introducing a high-tech revolution and even influencing our daily lives. Surpassing bifurcation and instability yields unprecedented deformational capabilities and going beyond the concept of the elastic potential leads to materials capable of absorbing energy from the environment in a closed cycle of deformation and releasing it upon request. The road to this new paradigm is the fusion of the concepts of structural mechanics with the principles of solid mechanics, both brought to the highly nonlinear realm of extreme deformation. This opens virgin territory, left unexplored since the 100-years-old definition of the elastic potential, which has been treated until now as inviolable dogma. But structural engineers know structures capable of harvesting energy from the wind or becoming dynamically unstable when subject to follower loads, so that the implantation of these structural concepts in microscale form into a macroscopic solid leads to the creation of materials surpassing the concept of elastic potential and opening new horizons in the design of new materials. Our recent work exhibited that a purely elastic and conservative system can experience flutter instability. This strongly implies that an elastic solid can be devised that will exhibit this instability and violates hyper-elasticity. Implementing these concepts at the microscale (with elements generating microscopic interactions to suck/deliver energy from/to external sources) leads to architected materials which may harvest energy, or release it to move a mechanism, or propagate a signal with amplification, or suffer a Hopf bifurcation and self-oscillate at designed frequency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards an Atacama Large Aperture Submillimeter Telescope'.

assistant: **Innovation**

Observations of the sky at sub-millimeter and millimeter ((sub)mm) wavelengths have yielded transformational results in the study of the origin of chemical complexity, the birth of stars and planetary systems, the evolution of galaxies across cosmic times and the large-scale architecture of the Universe. The current generation of 10-meter class single-dish (sub)mm telescopes has opened a new window for astronomical discoveries, by revealing physical processes and components that are invisible at shorter wavelengths. These facilities, with interferometers used for detailed follow-ups, have enabled astrophysicists to go far beyond the biased ""optical/infrared"" view of the Universe, often prompting major revisions of theoretical models. However, it is now clear that these previous facilities will not be able to meet the challenges of 21st century Astrophysics. Indeed, the astronomical community worldwide has agreed that a transformational leap in discovery potential can only be enabled by a next generation, large aperture (50-meter diameter), single dish telescope operating at (sub)mm wavelengths. We hereby propose a design study for the Atacama Large Aperture Submillimeter Telescope (AtLAST). Our vision of AtLAST includes: a 50-m class dish, with high throughput and a field of view of two degrees, located at a high, dry site in the Atacama desert where the transparent atmosphere enables observations at frequencies up to the terahertz regime. We envision AtLAST as an international partnership operating a facility telescope, and we will explore ways to make the observatory fully powered by renewable energy. Such infrastructure will be unique in the landscape of current research facilities. Our project aims to obtain a comprehensive feasibility study and telescope design t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cross-cultural Encounters – the Travels of Gender Theory and Practice to China and the Nordic Countries' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

This interdisciplinary project is concerned with the cross-cultural translation of knowledge and practices that may take place when different cultures interact, and the resulting production of new knowledge. Taking the travelling routes of gender theory and practice to China and the Nordic countries as the empirical object of study, the project will focus on the crucial questions of why and how knowledge travels or fails to travel. The project will explore in which forms and by whom knowledge is sent, received, understood, translated, or even rejected as well as the impact of these travels.The main objective is to develop an alternative travelling theory to facilitate an improved understanding of the cross-cultural translation of knowledge and practices. The project is significant for the European Research Area, as well as for governments, civil society and the general public in light of increased and new forms of cross-cultural interaction between Europe and Asia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Component-Based Design meets Model-Driven Engineering methodologies: improving the development of Embedded Systems' under Seventh Framework.

assistant: **Concept**

Embedded systems are those systems in which the software is embedded into a hardware product, ranging from mobile phones to aircraft navigation controllers. They usually must satisfy timing constraints and resource usage such as CPU, energy, memory, bus bandwidth. Model-Driven Engineering (MDE) and Component-Based Development (CBD) can be seen as two orthogonal approaches to deal with the ever increasing complexity of modern embedded systems development. The former aims at making applications resilient to technology evolutions by abstracting the business logic from platform/hardware details, while the latter promotes the reuse and recombination of already realized and validated software units. Despite the fact that the adoption of MDE mechanisms in CBD could be profitable for reducing complexity and for improving reusability, these are still prevented by the lack of a rigorous formalization of CBD concepts into the MDE field. This project aims at joining complementary expertise gained by the hosting organization in CBD of embedded systems and the state-of-the-art knowledge in MDE techniques carried in by the research fellow. The expected outcomes are manifold, both from the researcher and the hosting organization sides, notably: - advance of the current state-of-the-art methodologies devoted to embedded systems development; - development of new skills for the research fellow; - enrichment of the education and training activities provided by the hosting organization to both students and industrial partners; - integration of researcher's activities into the host environment to build up a career advancement path.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'TRANSlating the role of Mitochondria in Tumorigenesis'.

assistant: **Objectives**

The consolidation of the knowledge that cancer is not only a genetic, but also a metabolic disease, has led scientists to investigate the intricate metabolic plasticity that transformed cells must undergo to survive the adverse tumor microenvironment conditions, and the contribution of oncogenes and tumor suppressors in shaping metabolism. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because these organelles have a crucial role in the energy and biosynthetic intermediates production but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. TRANSMIT aims to dissect the metabolic remodeling in human cancers, placing the focus on the role of mitochondria and bridging basic research to the improvement/development of therapeutic strategies. Further, TRANSMIT fosters the communication of this emerging field to the patients and their families. To these aims, TRANSMIT will create a network of seven different countries, among which world-leading basic science and clinical centers of excellence, several industrial partners with up-to-date omics technologies, as well as non-profit foundations and associations who care for cancer patients. By creating the critical mass of scientific excellence, TRANSMIT will allow to transfer the current knowledge into the wide field of cancer research, translating scientific and technical advances into the education and training of eleven Early Stage Researchers. TRANSMIT will implement training-through-research dedicated to unravel the metabolic features of cancer, as well as to provide a full portfolio of complementary skills through the creation of a net