RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Understanding emergent physical properties of chromatin using synthetic nuclei'.

assistant: **Objectives**

The main aim of this proposal is to resolve how the physics of molecular-scale activities result in the emergent material properties of chromatin and how those contribute to chromatin organization and function. Mounting evidence suggests that the material properties of chromatin regulate essential nuclear processes. Chromatin has been studied with two disconnected approaches; pure in vitro studies, perfectly suited for careful biophysical measurements on single DNA molecules but lacking the complexity of a cell, or intact cell measurements, with limited access to measure material properties and small-scale chromatin dynamics. The physical properties of chromatin, however, are emergent and result from the molecular activities that are in turn regulated by those properties. As a consequence, it is crucial to establish new experimental assays that connect these two scales and levels of complexity.  Here, I will bridge the gap in scales and biochemistry between pure in vitro assays and measurements in intact cells by reconstituting chromatin processes in Xenopus laevis egg extracts across scales. I will combine quantitative microscopy, optical tweezer measurements, and theory to biophysically characterize the self-organization of protein-DNA co-condensation and loop extrusion and single chromatin molecules of increasing complexity. To bridge the microscopic and the macroscopic scales, I will assemble synthetic nuclei made of pre-engineered DNA sequences, which allows for exquisite control of DNA length, amount, and chromatin activities. In combination with microrheology, micropipette aspiration, and magnetic tweezers, I will unravel how the collective behavior of chromatin activities gives rise to the emergence of large-scale material properties of chromatin.  This project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Establishing in-depth services enhancing the innovation management capacity of South West of France SMEs in 2020-2021' to be submitted under Horizon 2020.

assistant: **Abstract**

Raising the competitiveness of SMEs from South West France by offering services linked to innovation management.The project involves 3 partners of the Enterprise Europe Network South West France consortium which covers the region Nouvelle-Aquitaine and the Midi-Pyrénées territory. The general objective is to contribute to raise the competitiveness of SMEs from this area by offering support services in the area of innovation management. The project will also contribute to develop more efficient and more effective innovation processes and higher quality innovation management capacity assessment and support services. The support will be delivered as service packages to 2 groups of SMEs:a) Beneficiaries of the Horizon 2020 SME Instrument phase 2, Fast Track to Innovation and Future Emerging Technologies Open: to enhance the probability of a successful exploitation of the innovation project results and lead to the sustainable growth of the beneficiary beyond the participation in Horizon 2020. The support service will pinpoint weaknesses in the innovation capacities of the beneficiary, select suitable coaches to address the identified weaknesses and monitor the coach-client relationship and to accompany the beneficiary through their European project.b) SMEs with significant innovation activities and a high potential for internationalisation: to enhance their innovation management capacities to be able to gain new international markets and leaderships. The support service will consist in an in-depth innovation assessment in order to develop and implement a tailored action plan to improve the SMEs capacity to manage innovation processes. The partners will use dedicated assessment tools: IMP3rove, Check’Innov, Innovation Way and CCI MAP.The project will last 24 months and will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Extended Public-Private Partnership for Investment in Smart Energy Efficiency Projects in a Social Housing context'.

assistant: **Innovation**

An important component of a more socially and economically inclusive urban transition is the ability of the cities to implement energy efficiency and renewable energy (RES) projects and initiatives, especially in the housing sector. Despite the progress already made, the large-scale impact that was expected towards promoting energy efficiency is still far off from being fully achieved. The SUPER-i project will provide a significant contribution to generating investments and collecting data on energy efficiency in the social housing sector. Energy efficiency (EE) renovations of social housing can generate a significant social impact by reducing energy poverty. The objectives and impacts of the SUPER-i project will assist and support the European Commission to implement the European Green Deal. The general objective of SUPER-i is to support the funding of EE refurbishment of social housing stocks across Europe while increasing the share of renewable energy in the final energy consumption through the following specific eight objectives: 1) Tailored ePPPs (EE Public Private Partnerships) and roadmaps; 2) Capacity building among financial investors; 3) Data gathering and processing; 4) Integration of EE investments within portfolio management strategies; 5) SUPER-i KPIs; 6) Awareness and Replicability; 7) SUPER-i investment pipelines; 8) SUPER-i Roadmap and Platform. The SUPER-i project will contribute to generate substantial investments in energy efficiency within the social housing sector in two folds: 1) by establishing a direct dialogue, at local government level, between financial institutions, other private investors and social housing managers while also involving ESCOs (Energy Service Companies); 2) by collecting relevant data on EE investments, helping to develop ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Diaphora: Philosophical Problems, Resilience and Persistent Disagreement' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

DIAPHORA serves as a European research and training platform for collaborative research on the nature of philosophical problems, their resilience and the sources of persistent divergence of expert opinion about them, and their relation to conflicts in the practical sphere. More specifically, DIAPHORA’s 3 principal research objectives are (A) to diagnose what makes philosophical problems so resilient and to clarify to what extent the sustained lack of convergence in philosophy can successfully be explained by the hardness of its problems; (B) to explain why the tendency has not been towards a general agnosticism about candidate solutions, but rather towards divergence, and to identify features of philosophical method that allow for such persistent peer disagreement; and (C) to explore whether the dynamics of philosophical debate, despite the subject’s highly theoretical nature, bears important and instructive resemblances to the dynamics of debates about more practical matters and their political and socio-economical antecedents – and hence whether philosophical problems and their attempted resolution can illuminate, and be illuminated by, the procedural and methodological difficulties besetting strategies for the adjudication of public affairs, thereby determining what philosophical thought might contribute to society at large. DIAPHORA joins 7 leading European research centres in philosophy, and 5 partner organisations, 3 of which from the non-academic sector, in the fields of international conflict management, mediation and policy-making, as well as the analysis of social conflict and cultural diversity. It undertakes to provide 14 Early Stage Researchers with the knowledge and skills necessary to meet the demands of top-level research within its remit, as well as pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'In Blockchain We Trust(Less):  The Future of Distributed Governance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The general malaise of liberal democracies—characterized by a gradual erosion of trust in traditional institutions (such as banks) and new intermediaries (e.g. social media)—has spurred the development of new blockchain-based applications (like Bitcoin) that allegedly obviate the need for trust. Often described as a “trustless” technology, blockchain’s potential for disintermediation has been touted as a catalyst of innovation that could displace existing power structures. But is it shifting power away from former centers of power only to create new ones, or can it lead to an actual new organisation of power?BlockchainGov is an interdisciplinary project that will study the impact of blockchain technology on new and existing governance structures, and its consequences for legitimacy and trust.First, it will investigate the governance of existing blockchain systems, and analyse the power dynamics at play within these systems.Second, it will examine the legitimacy and long-term sustainability of existing attempts at distributed governance, through the lenses of legal and political theory.Third, it will explore the potential of blockchain technology to support new models of distributed governance providing an architecture for decentralized and participatory decision-making with attributes of transparency and accountability.Last, it will experiment with these new models at different levels of governance, from the community level to the global governance level.The  project will open a new field of scholarship on “distributed governance” that uniquely combines the disciplines of computer science, political science and law. It will provide key empirical and theoretical contributions to science, with important policy implications to the broader questions of global governance.Bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identifying RNA fate checkpoints by resolving the high-resolution spatiotemporal binding dynamics of CBC containing complexes' (RNAfate), addressing dissemination and exploitation.

assistant: **Impact**

High-throughput transcriptomic analyses in human cell lines have found that >80% of the genome is transcriptionallyactive. A major part of this massive genomic output is derived from RNA polymerase II (RNAPII) activity; such as, mRNA,sn(o)RNA and long non-coding RNA. However, although these transcripts all contain 5’-m7G caps, which are commonhallmarks of RNAPII-derived transcripts, their fates differ substantially as some are rapidly degraded while others remainstable and exercise diverse functions in the cell. What is the underlying mechanism? Transcript fate decisions are ultimatelydictated by the proteins with which the nascent RNA associate. Central to this process is the cap-binding complex (CBC).Through its early association with the 5’-m7G cap, the CBC directs a plethora of nuclear RNA metabolic events by servingas a landing pad to recruit productive and/or destructive factors. Therefore, composition of the early RNA-protein particleplays an essential role in dictating RNA fate, and the CBC and its cofactors pose an interesting dichotomous system to studyas a model for sorting mechanisms dictating RNA fate.In my project, I will delineate the spatiotemporal recruitment kinetics of selected RNA metabolic factors to identify when RNAfate decisions are made during transcription and how RNA/DNA elements contribute. To resolve the sequential loading ofthe CBC and its cofactors onto elongating transcripts, I will develop time course UV cross-linking and immunoprecipitation(CLIP) experiments, combining metabolic labelling of RNA, using the photoactivatable ribonucleoside analogue 4-sU, with anew and unprecedentedly high powered UV cross-linking technology employed at multiple short time increments. This willfor the first time enable the study of in vivo RNA binding kine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowledge based system for the design of forming sequences and tools in cold forging of fasteners for the automotive industry' in the context of a Fourth Framework call.

assistant: **Objectives**

The project consists in developing a system that assists in the definition of manufacturing sequences for forming, and tooling of parts by cold working of steel wire, leading to production rates ten times greater than with machining. The objective of concerned SMEs is to increase the throughput of their engineering shops, reducing by half the billet turnaround time between the beginning of the study of a part and start up of serial production; to improve the accuracy and the reliability of cost estimates; to obtain higher quality; and to benefit from feedback to the engineering shop of production experience. The principal R & D tasks will consist in: modelling of parts and of the steps in the forming processes, automatic selection of parts similar to the new part under study, using fuzzy filtering methods with a database, constituting expert modules transcribing the know how of the concerned SMEs regarding different types of forming, as an aid in validating the final production process. The project will lead to integration with the techniques of the different engineering shops, in association with CAD/CAM tools already used by operators. The expected consequences are: a significant increase in the competitiveness of the concerned SMEs thanks to reductions in cost and in engineering time, the ability to produce small series under competitive conditions and, thus, better resist imports of simple" parts, especially from developing countries, an improved aptitude to manufacture complex parts, traditionally equirings of cold working: high hourly production rates and manufacturing without material loss, the upholding of a technological edge over countries having low labor costs."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Stimulating road Transport Research in Europe and around the Globe for sustainable Mobility' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The STREnGth_M consortium will contribute significantly to the planning of research and innovation in Europe by identifying future research needs in the field of road transport, by updating and supporting the coordination of strategic research agendas and roadmaps in the field and by facilitating continuous exchange between road transport research related Horizon Europe partnerships and platforms. It will further analyse research, innovation and cooperation capacities in Member States, explore funding instruments on national and regional level and assess potentials of national and regional roadmaps. Within STREnGth_M the global progress of electric mobility will be tracked while measuring the feasibility of innovative solutions for prospective and emerging markets in Africa, Asia and Latin America. This will contribute to strengthen exisiting and even forge new links between European, national and regional programmes and support structures for international cooperation task forces. The partners will also identify barriers that may exist for the deployment of research results on European and on international level and they will identify education and training actions to contribute to capacity building. In order to inform and engage the vast stakeholder community, policy makers, the civil society and more, the consortium will develop elaborate dissemination strategies, support the dissemination and organisation of European and international road transport research related events. This way the dissemination of the contribution from road transport to the realization of the European Green Deal targets and the Paris Agreement can be ensured. Via the establishment of the so called Multiplier Group the engagement of the various stakeholders will be facilitated throughout the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Economic growth with unemployment and wage inequality - the role of market frictions' (1994-1998).

assistant: **Concept**

An endogenous growth model will be constructed in which workers absorb a fraction of the economy's continually growing stock of public knowledge by investing in education. The level of schooling undertaken is assumed to be a key determinant of the rate of economic growth. Once schooling is completed, workers are brought together with vacancies/firms via a stochastic matching technology, designed to capture the degree of market frictions. The labour market is populated by overlapping generations of workers of differing productivities. The model can explain the observed negative correlation between wages and the unemployment rate. Furthermore, the characterisation of the wage structure across different generations will allow us to examine issues pertaining to wage inequality. Finally, calibration methods can provide a quantitative assessment of the effects of alternative economic policies, which improve the organization of the labour market, on economic growth, unemployment and the wage distribution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nanoengineering of radioactive seeds for cancer therapy and diagnosis'.

assistant: **Objectives**

One of the major challenges in modern society is the early diagnosis and treatment of diseases. Cancer is one of the most relevant diseases worldwide because of its incidence, prevalence and mortality. During the past decades, considerable efforts have been devoted to understand the origin of the disease, find early detection methods that could improve the survival rate of cancer patients or develop treatments and devices that could reduce or eradicate cancer. The application of nanotechnology to medicine (nanomedicine) has become one of the most promising routes for the diagnosis and treatment of diseases. The small size of nanomaterials, large surface area and high reactivity impart unique physicochemical properties to these materials, in such a way that several therapeutics based on nanomaterials (liposomes, nanoparticles, polymers) have already been approved for clinical use in humans. However, there are still limitations that need to be overcome to obtain novel and efficient nanocarriers for oncology applications.NEST presents an innovative approach that aims to engineer ultra-sensitive imaging and therapeutic agents. An unprecedented amount of ‘hot’ radionuclides, in the form of crystals, will be hermetically sealed in the interior of hollow nanostructures (seeds), thus preventing leakage and interaction of the radionuclides with the biological milieu. The in vivo fate will thus be merely governed by the nanocarrier and will be alien to the encaged radionuclides. Rational engineering of the nanoseeds in terms of size, shape and surface properties will be employed to tune their pharmacokinetic profile and biodistribution, including tumour targeting. The large amount of radionuclides encased in each of the seeds is expected to allow a more personalised treatment of