RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Autonomous Prostate Biopsy' under Horizon 2020.

assistant: **Concept**

The PROST PoC proposal aims at demonstrating the technical, clinical and economical feasibility of autonomous prostate biopsy execution, by applying the technologies developed by the ERC project ARS (Autonomous Robotic Surgery) to a robotic prostate biopsy system. Prostate biopsy is a good candidate for the application of automation in clinical practice since it is a rather simple procedure, carried out on more than 1 Mil/year patients in Europe, and still affected by a diagnostic error higher than 30%. This means that about 300,000 patients in Europe alone, are directed to therapies that will require repeated biopsies or will make the patient undergo unnecessary surgeries. Errors are mostly due to human inaccuracy in identifying the correct biopsy target and in executing the free-hand biopsy. The PROST project aims at removing the human from the identification/execution process, thus reducing the diagnosis and execution errors. The project is made feasible by two enabling factors: the on going ERC project ARS that is developing sensing and control architecture for autonomous surgical robots, and the availability of a prototype of robot for prostate biopsy developed with a grant by the Italian Ministry of Foreign Affairs and International Cooperation. The PROST project will integrate the sensing and control architecture with the biopsy hardware and avoid lengthy hardware and software development. Thus, the first objective of the proposal is the technical validation of the autonomous prostate biopsy system. Then, extensive cadaveric tests will determine the clinical rationale to use an autonomous robot for prostate biopsy. Finally, the third objective of PROST is to develop and validate a business case for the commercial exploitation of the PROST prototype, addressing lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Dlx-1 and sek-1 expression during schwann cell development'.

assistant: **Objectives**

In the development of Schwann cell lineage, multipotent neural crest cells give rise to Schwann cell precursors, which in turn differentiate into Schwann cells. The aim of this project ist to analyse the involvement of the putative gene regulatory protein Dlw-l, and the tyrosine kinase receptor Sek-l, in Schwann cell development. Different observations raise the possibility that these two genes might be involved in the Schwann cell differentiation. First, Dlx1 is a member of a novel family of vertebrate genes sharing a homeodomain sequence similar to that found in the Drosophila Distal-less gene. During mouse development, Dlx-l is detected in different neural crest cell derivatives and is likely to be expressed by Schwann cell precursors. Second, Sek-1 belongs to the Eph subfamily of receptor tyrosine kinases. During mouse development, Sek-1 is co-expressed with Krox-2O which is expressed in Schwann cells before the onset of myelination. The aim of the present project is: 1) To study the expression patterns of Dlx-l and Sek-l in the Schwann cell lineage, and to relate them to known developmental transition points. 2) To investigate the role of different growth factors, known to be involved in Schwann cell differentiation, in the regulation of DIx-1 and Sek-l expression. 3) To interfere with Dlw-l and Sek-1 expression using antisense technologies in order to study the direct involvement of these two genes in different steps of Schwann cell generation and Schwann cell differentiation. 4) To inhibit the interaction between Sek-l and a putative ligand by means of a soluble form of Sek-1 receptor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Safer and ecologically sound roadside safety systems through novel design with advanced polymeric composite' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In the definition phase of the project research was directed towards the requirements and design specifications for both demonstrators. The application areas for safety fences were defined as: Bends, bridges and fly-overs in secondary roads; for lighting columns: The 10 metre column was considered to offer the optimum contribution to passive safety.Based on a survey of energy absorbing mechanisms a number of design concepts were developed. Using multi-body software Madymo and Vedyac impact behaviour of vehicles was evaluated, finally resulting in the choice for two demonstrators: a patented Tilting Bird" system for the safety fence and a tapered 10 m Lighting Column.For these kinds of applications materials and specific processes were developed and selected: pultrusion and sheet moulding compound technology for the safety fence and vacuum injection for the columns. Assessment of the applicability of thermoplastic materials for inclusion in the safety fence was also undertaken.Safety fence:The properties and requirements of safety fence components have then been defined in detail. Coupled with the evaluation of impact performance a material selection was made for each element of the safety fence.The design of the overall geometry together with component geometry (beam and post) was completed using Vedyac, Madymo and FEM software. In depth analysis was conducted on the jointing techniques between all elements of the Tilting Bird system and as a result the dynamic behaviour of the connections were established.Resulting from the dynamic impact testing on ground anchor and ground anchor post connection, the design of spacer and ground anchor was almost completed.Two full-scale tests were performed according to the CEN standard prEN 1317. The test with the car (900 kg/100kph/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of efficient cellular systems for industrial production of human recombinant collagens to be used as biomaterials and in oral tolerance' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Of the 19 known types of collagen, commercial use is presently limited to type I collagen used as biomaterial and type II collagen used as a therapeutic, because only these collagen types are readily available from animal tissues, and no human sources exist. Collagens can be used as components of medical devises, in injectable form, and in drug delivery. A new field of application is oral administration of collagens in certain autoimmune diseases, such as rheumatoid arthritis. Despite the obvious need for recombinant human collagen, production of recombinant collagen with cost-effective expression systems, such as insect cells, yeast or bacteria, have been hampered by the complex post-translational modifications required for production of collagens. The objective of the proposal is the development of cell lines of industrial importance, namely insect cells and yeast, to allow expression of native-like triple-helical recombinant human collagens. As a result of co-expression of human collagens and human prolyl 4hydroxylase, the key enzyme of collagen synthesis, we have successfully produced large quantities of native-like triple-helical human type II and III collagens in insect cells. Furthermore, our results suggest that by using the multi-gene expression approach it will be possible to modify yeast to produce even higher amounts of human collagen. The application combines an integrated approach by academic and SME partners to further develop means of producing cost-efficiently in large-scale any human and animal collagens using recombinant technology, and to evaluate the properties of the produced recombinant collagens in order to allow selection of the most suitable production system for the various collagens and to understand the biological diversity of the them. A si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A PROSPECTIVE EUROPEAN VALIDATION COHORT FOR STEREOTACTIC THERAPY OF RE-ENTRANT TACHYCARDIA' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Ventricular tachycardia (VT) is an unpredictable and potentially deadly condition and should be promptly treated with catheter ablation and medication, before irreversible and potentially fatal organ damage follows. Unfortunately, this combination of treatments does not prevent VT reoccurrence in 30-50% of VT patients and while they can undergo multiple invasive ablations, technical difficulties or refusal of the patient can lead to a lack of effective treatment options. A promising novel, non-invasive treatment option for VT is stereotactic arrhythmia radioablation (STAR). Besides being non-invasive, STAR can also be used to reach locations that are inaccessible for catheter ablation, which may potentially improve effectiveness of overall VT treatment.Small scale first in men/early phase trials have been performed for STAR, providing proof-of-concept for clinical safety and efficacy. However, patients with recurrent VT are not a homogenous group and each center deals with different inclusion criteria, imaging and/or target definition. Many questions remain and the available studies lack the power to clinically validate the approach and prepare for late stage phase III trials.The STOPSTORM consortium sets out to consolidate all current and future European efforts to clinically validate STAR treatment by merging all data in a validation cohort study, standardising pre-treatment and follow-up, in order to collect the data sets and statistical power needed to unanimously establish clinical safety, efficacy and benefit for STAR. The STOPSTORM consortium also sets out to refine protocols and guidelines, determine volumes of interest, define and model the optimal target region and target dose, also in relation to surrounding healthy tissues (i.e. organs at risk) and determine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Systems Biology of Membrane Trafficking'.

assistant: **Innovation**

Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium. Although we have gained detailed knowledge on the molecular organization of membrane trafficking machineries a global view of its function and regulation is lacking.  To date membrane trafficking is often regarded as a constitutive process with a high degree of functional redundancy. However, the fact that mutations of single trafficking genes with ubiquitous expression give rise to tissue-specific human diseases and discrete sets of trafficking genes have differential effects on tissue development challenge this view.Here, using a combination of state-of the-art technologies, we will apply a systems biology approach in specialized cell types to establish a physiological and functional spatiotemporal map of membrane trafficking genes and proteins (membrane trafficking modules; MTMs). To this end we have curated a list of 1,187 genes representing ER, Golgi, Endosomes and Lysosomes (EGEL) around which we develop independent but interconnected approaches: (i) RNA-seq and antibody microarrays to identify co-regulated MTMs; (ii) high-content siRNA screening to define functional MTMs; (iii) epistatic functional analysis between EGEL genes and five membrane trafficking disease genes (TRAPPC2 in chondrocytes, Sec23A in osteoblasts, OCRL and CLCN5 in proximal tubular epithelial kidney cells, and VAPB in neuronal cells); and (iv) studies of protein-protein interactions to generate functional  and physical networks centered on the disease genes.SYSMET will generate a unique resource by defining the impact and interplay of the different regulatory layers of the entire membrane trafficking system with important implications for human health.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of the molecular mechanisms of cell migration by using high content screening and siRNA technology' (SIRNA-HCS) targeting Sixth Framework.

assistant: **Abstract**

Cell migration is a key step for the development of inflammatory and metastatic disease. Mechanisms involved in cell migration include alterations in adhesion molecules and chemokine receptor status, activation of signalling molecules and cytoskeletal rearrangement. Cell-based high content screening (HCS) is a revolutionary technology which allows subcellular imaging of temporary cellular events as well as analysis of intracellular events, permitting the study of deeper biological information at the sub-cellular level.Hence, due to its high throughput capacity, this technology is likely to improve the bottlenecks in the process leading towards drug discovery, and the establishment of this technological platform in Europe will have immediate applications to many of the causes of morbidity and mortality within the European Union. The laboratory of Prof. Dermot Kelleher, the coordinator of this proposal, is one of the first academic institutions in Europe to acquire such a technology. In this application we propose to combine the efficiency of inhibitory small inhibitory RNA (siRNA) libraries with the high throughput capacity of cell-based HCS to the study of cell migration in the context of neoplastic diseases and inflammation.This project requests research fellows with expertise in the areas of cell biology/cell migration combined with HCS, IT/bioinformatics, molecular biologists with experience of inhibitory RNA and high throughput transfection technologies and cell biologists with industrial/drug screening experience. This transfer of knowledge to the host institution using siRNA in combination with HCS to study the molecular mechanisms of cell migration will be essential to help establish and develop this novel technology and its use to accelerate the process of drug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rehabilitation & revegetation of mining waste-dumps by the use of industrial&domestic sewage sludges from waste-water purification plants' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The utilization of waste as secondary raw material is a fundamental principle of the so called sustainable development, worldwide. Prerequisite for the usage of pollutant bearin } material isz that a negative impact on the environment can be excluded. Waste dumps resulting from open-cast and underground mining operations constitute a serious environmental problem if thev are not properly rehabilitated and revegetated. because untreated dump-sites form a source of continuous emission of dust fumes and a source of possible groundwater pollution. One significant cost-factor of the rehabilitation results from the neccessity of purchasing soils, if in situ soil is not available. This cost-factor could be substantially reduced by using the positiv physical, chemical and biological properties of mixtures based upon industrial residues (fly ash from power stations, red mud from alumina production, flotation tailings) and slewage sludges as a fertile component. Caping the waste dumps and at the same time create a fertile substratum for revegetation can contribute to the solution of safe diposal/utilisation of industrial residues and rehabilitation of waste dumps resulting from the mining industry. Additionally the usage of these residues as secondary raw material save natural resources and avoid the demand of disposal-site volume. Sludges, especially sewage sludges and industrial waste contains a large number of different potential contaminants, which causes environmental problems. This requires a methodology to deposit the artifical top soil in place and mix it with the uppermost layer of the waste dump and to prevent the toxic components of the mixture from being leached out of the soil. As a basic research project, the research aims at developing the initial artifical top soi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Secondary prEvention of CardiovascUlaR disease in the Elderly trial' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adherence reduces their effectiveness and is the primary reason for suboptimal clinical benefit, contributing significantly to worsening of diseases and deaths at the population level. SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for secondary prevention of cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke, and hospitalisation requiring revascularisation) as compared to standard therapy (the three components of the polypill given separately). As part of the secondary endpoints, SECURE will compare the effect of both strategies on adherence and intermediate measures of risk factor control such as lipids and blood pressure. Importantly, it will also measure the pharmacoeconomic impact of the FDC intervention as well as regional differences in all outcomes. The five-year project will thus involve subjects from seven different countries: Spain, Italy, France, Germany, Hungary, Poland and the Czech Republic. The findings and conclusions obtained in SECURE will allow the drafting of clinical guidelines and recommendations that will provide useful guidance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Consolidating the European Research Area on biodiversity and ecosystem services' to be submitted under Horizon 2020.

assistant: **Abstract**

The loss of biodiversity and degradation of ecosystems jeopardize the sustainable provision of ecosystem services and are major scientific and societal challenges. Addressing this challenge and providing scientific support to stakeholders and policy makers requires a coherent interdisciplinary research framework, with coordinated strategies and programmes at the national, regional and international levels, which are the relevant scales for many biodiversity issues.By networking 32 funding agencies from 18 countries, BiodivERsA3 aims to strengthen the ERA on biodiversity. Building on the previous experiences of the projects BiodivERsA1&2 and NetBiome, BiodivERsA3 will promote and support coordinated pan-European research on biodiversity and ecosystem services. It will strengthen research and research programmes coordination with the ultimate aim to provide policy makers and other stakeholders with adequate knowledge, tools and practical solutions to address biodiversity and ecosystem degradation. The objectives are to: - Enhance the capacity of the network to coordinate research programmes on biodiversity and ecosystem services more completely in Europe (including overseas territories) and to increase the international dimension of BiodivERsA activities- Develop a strategic, multi-annual vision of the networks priorities, based on ambitious mapping and foresight activities developed in collaboration with key initiatives in the field- Design and implement a co-funded call and other joint calls to better integrate research on biodiversity and ecosystem services across Europe- Develop a range of other joint activities, in particular alignment of national research programmes for biodiversity and ecosystem services, and activities for promoting mobility and equal opportunitie