RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modularisation and containerisation of floating diesel driven electricity power plants for assembly and use in remote areas' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Floating diesel-driven powerplants are very complex installations. The building and testing of these installations require extreme skills/know-how and a lead-time from at least three to four years. The installations are nowadays only being built in well industrialized areas, where all necessary know-how is available directly and on-spot. This results in firm lead-times between the powerplant being readily built and the start of its actual operation in the remote-area (mainly Far-Asian) it was ordered for (because of the towing-trip). The RTD-goals of this project can described as: a. electro-technical solutions to subdrive a 'large' powerplant (larger than at least ten megawatt) into smaller power-packs of which groups can easily be integrated to a larger installation that supplies high power outputs b. mechanical and constructional innovation that enable these powerpacks to be assembled to a large powerplant without the need of a high level of skills or know-how c. based on a. and b.: practically applicable work- and test-methods to adjust the integrated iand to bring it into operation. (Nowadays this requires a high-levelhow and skills and cannot be done in remote areas without the in-flighrge specialised staff).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Universal Model of Word Comprehension' (UNIVERSAL) targeting Seventh Framework.

assistant: **Abstract**

The proposed research will develop a “universal” connectionist architecture and a set of models capable of handling key cross-linguistic differences across English, Spanish, and Hebrew.  This work is complemented with targeted empirical investigations.Computational Investigations.  I will develop improved connectionist models which employ more general architectural assumptions and that are able to learn to comprehend words from languages that impose different division of labour between orthography, phonology, and semantics.  These models will explain and generate predictions regarding how a general architecture and the statistical properties of a language give rise to a range of cross-linguistic differences reported in the behavioural literature.  This will be accomplished by combining a model of English, Spanish, and Hebrew with a response generation model to simulate performance in a range of tasks (e.g., differential transposed-letter priming in English & Spanish vs. Hebrew; stronger syllable priming effects in Spanish vs. English; greater semantic priming in naming Hebrew vs. English and English vs. Spanish).  Additionally, the models will be developed within a biologically-plausible connectionist framework to connect the model to the ERP literature (Armstrong & Plaut; 2013; Laszlo & Armstrong, 2013).Behavioural & pilot EEG/ERP Investigations.  To evaluate the modeling work, behavioral (and pilot electrophysiological) data will be collected from masked priming lexical decision tasks designed to engage orthographic, syllabic, and semantic representations.  Language development will also be studied in pilot behavioural experiments with children.I will develop and release a public implementation of my empirically-validated models and data.  These models will account fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reverse engineering the assembly of the hippocampal scaffold with novel optical and transgenic strategies' to be submitted under Horizon 2020.

assistant: **Abstract**

We aim at shedding a unique light on hippocampal function at circuit level through the design of a novel method to trace the construction of brain circuits in health and disease based on hybrid multiphoton in vivo longitudinal color imaging of the dynamics and structure of genetically-tagged neuronal clones from birth into adulthood. This is made possible by the exceptional interdisciplinary collaboration of three labs with expertise in advanced optical microscopy, genetic engineering and systems developmental neuroscience. Our novel methodology, applied here to the  hippocampus, will pioneer a new way to track the emergence and plasticity of heterogeneous neuronal circuits as these progressively give rise to function in physiological and pathological contexts, thus bridging the gap between early development and adult circuit physio-pathology. This will enable us to revisit adult hippocampal function from a developmental perspective. The hippocampus is classically described as providing a cognitive map of space, involved in navigation, learning, and episodic memory. However, a more computational and less representational vision of its role presently emerges in which its circuits are best described as producing sequences of neuronal activation arising from the interaction between external contextual inputs and internally-generated preconfigured dynamics. Converging work including ours leads us to hypothesize that internally preconfigured assemblies, shaped by their developmental journey, are the basic modules of hippocampal function. In this context, we will use our new approach to address three interrelated questions: 1) Are assemblies shaped by specific circuits in the adult hippocampus (objective A)? 2) Are they prewired or shaped by experience (objective B)? 3) What
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nano-Particle-Resolved Studies' (NANOPRS).

assistant: **Concept**

Amorphous materials may be classified into three types – thermodynamically stable liquids, metastable (supercooled) liquids and solid glasses. The second type represents the meeting point of many of the great challenges of statistical physics and materials science. What is the mechanism of dynamical arrest, by which structural relaxation become progressively inhibited upon cooling from a liquid to a glass? Can we develop physical pictures of the sequence of fluctuations associated with irreversible relaxation in metastable liquids? How do crystals emerge from these fluctuations?Here we take a structural approach coupled with novel experiments and computer simulations to tackle two specific questions. Firstly, it has long been believed that there should be some structural mechanism underpinning the glass transition, where deeply supercooled liquids continuously transform into solid glasses. Secondly, the fate of the supercooled liquid – whether it crystallises on accessible timescales – should also be related to the local atomic arrangements in the liquid. Tackling the first will lead to insight into the nature of the glass transition - it is not known whether or not there is a true thermodynamic transition to a glass. As for crystallisation, predicted nucleation rates vary wildly with those obtained experimentally in the only system in which both have been compared, little is known beyond trial and error of means by which crystallisation in mixtures can be controlled. In short, our understanding of the fate of supercooled liquids is lacking in a variety of ways. Understanding the glass transition and nucleation is of fundamental importance, and both have important applications for example in metallic glasses and phase change materials. The former are prized for their su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Preclinical proof of concept of AF243 potency to prevent and/or treat sensorineural hearing loss' (AFHELO).

assistant: **Innovation**

Approximately 10% of the global population (40% of people over 65), suffers hearing difficulties. The socio-economic impact is deep, since in children, early hearing impairment (HI) affects language learning, and in adults, acquired HI impairs social integration. The sense of hearing depends upon the integrity of the sensory epithelia in the inner ear. HI occurs when this tissue is disrupted, that is when the sensory hair cells (HC) die and the spiral ganglion neurons (SGN) subsequently degenerate and die. To date, there is no potent curative or preventive solution for HI, the clinical options are based on the use of prostheses such as cochlear implants. Studies are being conducted to develop alternative treatments combining both preventive and reparative strategies. Since HC and SGN are of the same developmental origin, transcription and growth factors that modulate early development of the inner ear have been under the scope. These studies gave rise to two main therapeutic hypotheses, the use of exogenous stem cell with induction of their differentiation to HC and/or SGN, or the proliferation/transdifferentiation of cells supporting HC in the inner ear. Up to now, problems of cell death and control of the cell differentiation have slowed down the emergence of new therapies.To address this problem, AFHELO projects plans to evaluate potency of AF243, a small molecule which is a strong inducer of cell differentiation with interesting potencial on carcino-embryonic cells differentiation and neuron survival, and on an in vivo model of chemo-induced deafness, used for cochlear implant testing.The strategy is to optimize AF243 development by first extending the therapeutic applications to two major types of HI (noise-induced and age related/presbycusis) and second by complet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'River basin management in highly industrialised areas' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Water management in the Ruhr district is subject of DMT's research and engineering work for decades. On behalf of the provincial government DMT systematically mapped the hydrology and hydrogeology of the region at a scale of 1: 10.000. The fellow would participate in current research work at DMT' s Department of Hydrogeology and Water Management addressing impact of coal mine flooding on groundwater level and usage of groundwater as well as infiltration of precipitation on urban groundwater flow systems. Work consists of evaluating existing data, extended by some supplementary fieldwork and subsequent data processing for statistical evaluation, numerical modeling, and GIS-based data management. DMT's database and numerical flow models will become part of local and regional water management processes. In consideration of ground subsidence, which came practically to an halt after closure of underground coal mines, research work can now be dedicated to long term sustainable improvement of the water regime. In addition, the EU Water Framework Directive 2000/60/EC requires the administrative authorities to ensure the implementation of necessary improvements of the ecological status of the water bodies. DMT forms part of a joint research team with the Universities of Essen and Münster supporting regional water authorities to develop strategies for compliance with environmental objectives requested by the directive at reasonable costs and within the timescales available. Work has begun in 2000.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Brain Involvement iN Dystrophinopathies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in childhood, with more than 25,000 patients in Europe. It is due to mutations in the DMD gene that preclude the production of the protein dystrophin. In addition to the progressive muscle weakness, 50% of affected individuals have debilitating central nervous system (CNS) co-morbidities, including intellectual disability, neurodevelopmental problems encompassing autism, Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Disorder. These co-morbidities are due to the deficiency of multiple dystrophin isoforms in brain whose expression is differentially affected by the site of the DMD mutation. They represent a major obstacle for patients to live a fully independent life.  Current therapies do not address these co-morbidities. The postnatal restoration of one dystrophin isoform using genetic therapies in the DMD mouse model improves the neurobehavioral phenotype. This raises the exciting possibility that some of the CNS co-morbidities could improve with genetic therapies in patients. We need to address several knowledge gaps before considering clinical applications of these therapies: i. dystrophin isoforms localisation in the CNS; ii. which of the neurobehavioural features of the dystrophic mice improve after dystrophin restoration, and circuitries involved; iii. deep phenotype patients to define robust outcome measures. This project developed in partnership with advocacy groups, meets gender criteria and offers for the first time insight into how dystrophins’ affect CNS function, and on the reversibility of the DMD CNS co-morbidities, providing essential information to the field of neurodevelopmental disorders, and for other syndromes arising from dystrophin associated proteins. Our e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interdisciplinary Research on Development the the Environment: Methodological Issues. an International Workshop .' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This proposal involves the preparation and execution of a two-day international workshop on methodological issues concerning interdisciplinary research on development and the environment, with the participation of 24 European and Developing Country researchers (10 DC, 12 MS, 2 AS-Norway) with solid experience in conducting interdisciplinary research in this field. The workshop will be held near Oslo, Norway, in April/May 2000. Participants will be invited on the basis of personal professional experience, with a balanced representation from economics, sociology/anthropology, and the natural sciences. The workshop will concentrate on the following topics: Planning and undertaking inter-disciplinary research; Assessing interdisciplinary research; Connecting research and policy. The project will be coordinated/executed by the Centre for Development and the Environment (SUM), University of Oslo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Using real-time measurements for monitoring and management of power transmission dynamics for the Smart Grid'.

assistant: **Objectives**

Power transmission in Europe is entering a period of significant renewal and technological change because the electrical transmission grids face increases in new and variable energy sources, especially from large scale wind power generators. They therefore face future challenges of operation and control. Changes happening in the process industries will also have an impact on electrical supply because electric motors are taking over from traditional gas turbine drivers for large-scale process equipment such as compressors. On the other hand, new measurement and data acquisition methods such as phasor measurement units are allowing greatly improved observation of the transmission grid. In the light of these changes, there is a need for a new action to give Europe a significant lead in methods for enhanced power transmission system operation using emerging measurement technologies. The REAL-SMART proposal presents a balanced programme of applied R-and-D to address measurement-based monitoring and management of the high voltage transmission grid. It involves electrical transmission system operators, companies that supply technologies and components, and universities. The REAL-SMART consortium is interdisciplinary with experts in electrical power systems, modelling, instrumentation, signal analysis, equipment condition monitoring, and automation of oil & gas processes. The consortium will conduct research and undertake secondments to transfer experience and knowledge both ways between Academia and Industry. The project integrates in-depth understanding of the power system operational issues with analysis of state-of-the-art measurements and first-principles physical knowledge. It will invent and develop state-of-the-art tools that will be deployed by the transmission system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CitiObs – Enhancing Citizen Observatories for healthy, sustainable, resilient and inclusive cities' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

CitiObs will consolidate and apply tools and practice-based knowledge for co-creating data, knowledge and local action via Citizen Observatories (COs): these tools will enhance existing and new citizen observatories to engage citizens and marginalised communities, add value to environmental observations in the urban context, increase and validate citizen observations of the urban environment as part of the existing in-situ Earth Observation systems, co-create inclusive local actions for sustainability and ensure that CO data contributes to research and policy development towards the objectives of the European Green Deal. To ensure broad use, the CitiObs tools and approaches will be developed in co-creation with COs in 5 Frontrunner cities, finetuned with 30 Implementer cities and showcased to 50 Fellow cities.The pressure on cities to speed up the process of emissions reduction from pollutants and climate gases is overwhelming. The required measures are likely to be found not only in technological development but also in the required social transformations. Theseis transformations includes increasing citizen involvement and engagement with science and policy, increasing awareness of the underlying issues and promoting societal actions to protect the urban environment. Technological innovations need to be considered within the context of multi-level vertical and horizontal governance structures where citizen participation is recognized and included. CitiObs will support citizen observatories in distinct cities to create/enhance/or scale up inclusive and diverse citizen observatories, fostering in particular an active role of citizens in the observation of the urban environment using low-cost sensor technologies and wearables, with a particular focus on air quality and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Skin cancer risk factors and assessment of adaptive responses to solar ultraviolet radiation exposure'.

assistant: **Concept**

Solar ultraviolet radiation (UVR) causes skin cancer with serious health and economic consequences. The interaction of skin cancer risk factors is complex and poorly understood but genotypic, phenotypic, adaptive and environmental aspects are important. These vary in different European populations. Our aim is to study the genetic and pathophysiological basis of skin cancer risk factors, to examine their interaction and to determine their relevance to individual risk. We propose a combined epidemiological, photobiological and molecular approach to examine UVR exposure, skin type, anti-oxidant status, sunburn cell (SBC) formatior (apoptosis), UVR-induced immunosuppression and the generation of reactive oxygen species (ROS). UVR exposure data Personal UVR exposure profiles, determined with miniature electronic dosimeters, wil be undertaken in two different European populations. These data will be used to model cumulative individual UVR exposure dose by correlation with quantitative measurements of cumulative sunlight-induced biological changes such as skin photoageing. Calculated cumulative exposure dose will be used, in association with other biological and physical risk factors, such as skin type, anti-oxidant status and number of sunburning episodes, to determine individual skin cancer risk. The personal UVR measurements can also be used to validate recall of episodes of sunburning which is widely used in epidemiological studies. Acute and chronic effects of UVR on human skin Studies on healthy volunteers of different skin types, associated with different risks of skin cancer, and on skin cancer patients will be performed. - We will determine detailed UVB action spectra in human skin in vivo for SBC, p53 gene expression and cytokine release, parameters which we believe