RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The art of navigating social interactions: capturing social anxiety where it matters most', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Social anxiety (SA) has a profound impact on social functioning, but there is limited understanding of how SA individuals navigate the challenges of everyday social situations. These challenges consist of deciding how to communicate with others and how to regulate emotions evoked by those interactions, often under time-pressure and swiftly changing demands. Yet, the field has largely neglected the dynamic and socially interactive character of the challenges faced by SA individuals. This project builds on my conceptual innovation: SA should be studied where it matters most, during dynamic social interactions, considering emotion regulation decisions. It also builds on my methodological expertise: measuring neural dynamics during communication. These innovative backgrounds allow me to now develop a new neurocognitive framework for understanding the challenges SA individuals face when dealing with the communicative and emotional demands of social interactions. I will test how SA pairs solve communicative problems under evaluative pressure, while brain activity in each pair is simultaneously measured (WP1). I will use advanced methods to quantify of how pairs use their shared history to explore novel solutions to the communicative challenge. Further, I will identify neural systems supporting the selection of strategies to regulate emotions evoked by social stimuli (WP2). Casting emotion regulation as a dynamic decision-making problem between regulatory strategies moves the field beyond current SA research on the (in)ability to execute a single strategy. Finally, I will test whether difficulties to flexibly deal with communicative (WP1) and emotion regulation (WP2) demands in social settings can be explained by rigidity to adjust behaviour in unpredictable environments (WP3)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Oligopoly Markets and Networks' (Connections) under Horizon 2020.

assistant: **Objectives**

Via our connections we learn about new ideas, quality of products, new investment opportunities and job opportunities. We influence and are influenced by our circle of friends. Firms are interconnected in complex processes of production and distribution. A firm’s decisions in a supply chain depends on other firms’ choices in the same supply chain, as well as on firms' behaviour in competing chains. Research on networks in the last 20 years has provided a series of tolls to study a system of interconnected economic agents. This project will advance the state of the art by further developing new applications of networks to better understand modern oligopoly markets.  The project is organised into two sub-projects. In sub-project 1 networks will be used to model diffusion and adoption of network goods. Different consumers' network locations will summarise different consumers' level of influence. The objectives are to understand how firms incorporate information about consumers' influence in their marketing strategies—pricing strategy and product design. It will provide a rigorous framework to evaluate how the increasing ability of firms to gather information on consumers’ influence affects outcomes of markets with network effects. In sub-project 2 networks will be used to model how inputs—e.g., intermediary goods and patents—are combined to deliver final goods. Possible applications are supply chains, communication networks and networks of patents. The objectives are to study firms' strategic behaviour, like pricing and R&D investments, in a complex process of production and distribution, and to understand the basic network metrics that are useful to describe market power. This is particularly important to provide a guide to competition authorities and alike when they eval
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Riboescaper study: Protein synthesis driven by deficiently assembled ribosomes'.

assistant: **Concept**

Ribosomes are RNA-protein complexes found in all living cells. Ribosome biogenesis is a complex, cellular process that is tightly coordinated with ribosomes demand to ensure optimal cellular adaptation, growth and proliferation. In eukaryotes, ribosomes are sequentially generated in key steps where the ribosomal RNA (rRNA) is folded, modified, processed, and assembled with ribosomal proteins (r-proteins) to form the two ribosomal subunits. Recently, the connection of defective ribosome biogenesis with human diseases has become clear. This is the case of the so-called ribosomopathies, human syndromes caused by mutations in genes encoding either r-proteins or ribosome biogenesis factors, which are known to increase the probabilities of cancer development. Considering the multi-steps pathway of ribosome biogenesis, the possibilities to introduce errors with possible harmful effects for cell viability are high. In this context, cells have developed multiple surveillance mechanisms to supervise the structural and functional integrity of the ribosome particle. When a preribosomal subunit suffers an assembly error, in most of the cases, the aberrant particle is retained in the nucleus. However, some aberrant pre-particles have been shown to escape the surveillance mechanisms and to be exported to the cytoplasm.This proposal, aims to explore the functional consequences of r-protein gene mutations, which generate defective ribosomal particles that are successfully exported to the cytoplasm (RiboEscapers) and actively participate in translation in yeast cell. For this purpose, the research action will combine traditional yeast tools together with state-of-the-art methodologies, such ribosome profiling to provide a detailed overview of the r-protein roles in ribosome biogenesis, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dynamic Activatable Fluorophores' (DYNAFLUORS) targeting Horizon 2020.

assistant: **Abstract**

In DYNAFLUORS I will develop the first chemical toolbox for imaging in real time the activity of immune cells in tumours.Although the management of cancer has improved over the years, the cure rates for patients with metastasis and advanced tumours remain low due to lack of appropriate therapies. Recent studies suggest that drugs empowering host immune cells (i.e. immunotherapies) are promising approaches for intractable tumours. However, there are no tools to visualise and understand how host immune cells stop cancer progression in vivo. This important unmet challenge drives the ambitious targets of this proposal.Over the past 10 years, I have pioneered the development of chemical fluorophores that allow unparalleled analysis of biological systems. In this project, I will implement an innovative approach to unify cutting-edge methodologies in chemistry and biology and develop Dynamic Activatable Fluorophores (DYNAFLUORS) as a chemical toolbox with enhanced imaging capabilities over current technologies. The cross-disciplinary and ambitious nature of this project will open multiple avenues for broad impact in many areas of chemistry as well as in basic biology, imaging and medicine. DYNAFLUORS will allow us to image, from the molecular level to human tissue, the activity of immune cells in tumours and the response to therapy in real time. This ground-breaking chemical platform will represent a step forward in the forefront of chemical imaging and will create new opportunities in the personalised management of cancer.In the long term, DYNAFLUORS will become a transformative toolbox for monitoring disease in humans. The integration of functional fluorophores into imaging technologies to perform ‘optical biopsies’ in vivo and to create patient-specific drug-response assays
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Natural law and confessional cultures of slavery in Tranquebar, 1706-1800' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Natural law and confessional cultures of slavery in Tranquebar, 1706-1800. To what extent were colonial experiences with slavery, specifically the experiences of a Christian mission community, articulated with reference to the European natural law tradition? In addressing this question, the project examines the discourses as well as the practices regarding colonial slavery and the slave trade in the Danish-English-Halle mission in Tranquebar in south-east India, from its beginning in 1706 until 1800. Throughout the period, German missionaries as well as Tamil and European individuals who came into contact with the mission community, or were members, dealt with issues of slavery and the slave trade in Danish Tranquebar. The challenge of the project lies in studying these instances and examining the references to the theory of natural law that come up in the source material, including norms protagonists claimed to be self-evident in their view. Consideration of these two aspects, i.e. the practices of slavery and their theorisation, depends on a rigorous analysis of the agency of the German missionaries, the Tamil population and the members of the Danish colonial trading company in Tranquebar. The former aspect generally pertains to the field of cultural history, the latter to legal and intellectual history. By combining both approaches, the key insight to be gained by the project lies in revealing how colonial cultural practice – specifically, confessional cultures - took up the European intellectual debate on natural law. The impact lies in a deeper understanding of the cultural entrenchment of societal values by highlighting reflections on practices of slavery in the Tranquebar colony and its Danish-English-Halle mission.


**Keywords:** early modern history, natural l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Welfare state politics under pressure: Identifying priorities, trade-offs and reform opportunities among citizens, political and economic elites' to be submitted under Horizon 2020.

assistant: **Abstract**

In times of austerity, the politics of the welfare state involve tough choices and even trade-offs: whose risks should benefit from social solidarity in a context of shrinking resources? Should the welfare state prioritize the needs of the elderly or those of the young? Those of people in the workforce or outside of the workforce? Of natives or of immigrants? How countries answer these key questions depends on the welfare state priorities of citizens, political elites and economic elites. However, we know still very little about these priorities and their determinants, and we know even less about the mechanisms that foster support for social solidarity – i.e. support for inclusive social security beyond self-interest. This project wants to make use of recent methodological advances to investigate precisely these priorities and mechanisms. The project will have two phases: the goal of the first phase is to identify the most salient distributive conflicts and welfare trade-offs in eight European countries. It includes an original data collection on social policy priorities among citizens, politicians, employers and trade unions (based on conjoint survey and interviews), as well as content analysis of the actual welfare politics in these countries. The second phase builds on the findings of the first phase, but its objective is to go beyond conflict towards coalitions. It will again combine conjoint surveys and content analysis to identify the factors that foster support for social policies among those actors who are unlikely to benefit directly from these policies. The project will investigate the relative importance of three factors: compensation, framing and mediation. The project breaks new theoretical and methodological ground in comparative welfare state research. It
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Competitive SolAr Power Towers – CAPTure' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main objective of this project is to significantly reduce costs of concentrated solar power, in order to pave the way for its deserved competitiveness on the power market. Specifically, the solar-to-electric conversion efficiency of the plant will be improved by increased receiver operating temperatures as well as an innovative power cycle configuration also providing advantages regarding plant operation. Additionally, improved control methodologies based on dynamic multi-aiming-point strategies for heliostats will further enhance efficiency. Besides the improvement of the plants efficiency and operation, also the construction and operational costs will be minimized via mass production of heliostats and smart heliostat calibration systems.The global objective of this project is to increase plant efficiencies and reduce levelized cost of electricity (LCOE) by developing all relevant components that allow implementing an innovative plant configuration. This plant configuration is based on a multi-tower decoupled advanced solar combined cycle approach that not only increases cycle efficiencies but also avoids frequent transients and inefficient partial loads, thus maximizing overall efficiency, reliability as well as dispatchability, all of which are important factors directly related to cost competitiveness on the power market. The core topic of the project, the innovative solar receiver, will be an open volumetric receiver allowing operating temperatures beyond 1200 ºC, providing the absorbed solar heat to the pressurized air circuit of the Brayton cycle via a network of fixed bed regenerative heat exchangers working in alternating modes (non-pressurized heating period, pressurized cooling period).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of hemoglobin derived heme in atherocslerosis' (ATHEROHEME).

assistant: **Concept**

Atherosclerosis is the underlying process leading to the occurrence of cardiovascular diseases that accounts for one-third the world’s mortality. Although multifactorial the pathogenesis of atherosclerosis is triggered to a large extent by elevated plasma cholesterol levels, and by the oxidation of low density lipoprotein (LDL). The central hypothesis of this proposal is that proteins containing Fe protoporphyrin IX (heme) or free heme itself might act as central mechanism via which LDL is oxidized as to become atherogenic.The vast majority of heme is inside red blood cells (RBC) as the prosthetic group of hemoglobin (Hb). Under homeostasis a small percentage of RBCs lyses intravascularly, resulting presence of cell-free Hb in plasma. Several defence mechanisms evolved to cope with the deleterious effects of cell-free Hb, as well as those of heme itself. Plasma cell-free Hb is bound by haptoglobin (Hp), whereas heme binds to hemopexin (Hx). The formed Hb-Hp and Hb-Hx complexes are cleared from circulation by hemophagocytic macrophages and the heme is degraded by heme-oxygenase-1 (HO-1). This control mechanism prevents the accumulation of cell-free Hb or free heme in plasma while allowing iron recycling. The impairment of this control mechanism leads to severe oxidative stress-mediated pathologies, e.g. Hp-/- as well as Hx-/- mice develop severe renal damage in response to hemolysis, suggesting that this mechanism plays a central role in preventing the pro-oxidant effects of cell-free Hb or heme.Previous work from the applicant and others have demonstrated that LDL can bind free heme with high affinity with kinetics that are faster than those of Hx and can cause LDL oxidation. It is likely therefore that under conditions in which the plasma concentration of LDL and/or ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Doctorate Career Development and Mobility Studentships in Medical Device Research and Advancements: Enhancing the CÚRAM Industry-Academia Training Initiative' under Horizon Europe.

assistant: **Concept**

A major limitation for the introduction of novel medical devices to the market is the gap between research outputs and industry interactions. Innovations arising from academic institutions are rarely well aligned with commercial requirements (e.g. regulatory, pricing, patient needs). This impedes the efficient development of medical devices, which increases the time for innovations to reach patients. The Medical Device Doctoral programme, MedDevDoc, will address this gap by providing world-class research and training to 25 doctoral students. These students will be highly employable cross-border and -sector, capable of driving innovation in the European MedTech ecosystem.MedDevDoc is aligned with the EU principles for Innovative Doctoral Training, as well as the EU Charter and Code, and the Salzburg Recommendations. Novel aspects of MedDevDoc include a personal career development plan, which gives students a strong sense of ownership of their own career; a focus on sustainable laboratory practice by exploiting NUIG’s position as the first in Europe to be awarded a Green Lab certification; and extensive training in public engagement through the internationally recognised Education and Public Engagement programme, which is supported by experts such as teachers, filmmakers, and artists. The University of Galway (NUIG) is uniquely positioned to deliver MedDevDoc due to its position as headquarters of the CÚRAM network. CÚRAM is the national Science Foundation Ireland Research Centre for Medical Devices, created by the Irish government to close the gap between research and industry in the medical device field. NUIG will work together with the 8 other high-quality academic centres within the CÚRAM network, as well as 14 industry partners, to implement MedDevDoc. Upon completio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High load gear and bearings materials'.

assistant: **Innovation**

The Ultra High Bypass Ratio technology achieved with the geared turbofan concept, that decouples fan and turbine speeds by means of an Integral Drive System (IDS), is an innovative architecture that can enable significant reduction in fuel burn, noise and emissions.The HILOGEAR (High load gear and bearings materials) project supports the aims to mature differentiating technologies and processes that could be introduced in the innovatve drive system module for the UHPE (Ultra High Propulsion Efficiency Engine) demonstrator. Since classical aerospace materials, although performant, do not exhibit all the necessary technical characteristics to fulfil both bearing and gears strength needs for their application in the UHPE power gearbox, innovative materials and heat treatments have to be investigated.Therefore the main HILOGEAR project tasks and goals will be:•the selection, jointly with the TM, of promising materials and surface treatments suitable both for gears and bearings•testing activities on bearings also in contaminated conditions•testing activities on gears in high load and high temperature conditions similar to those of new engines. The activity will be managed with a Phase & Gate approach and will include detailed technical / program, documentation, including planning, drawings, design report, risk analysis, test plan and test requirements, test results and test analysis reports.


**Keywords:** gears, bearings, innovative materials and heat treatments, high load, high temperature, scuffing, pitting, bending