RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting the molecular mechanisms of transgenerational epigenetic inheritance' to be submitted under Horizon Europe.

assistant: **Abstract**

Small RNAs have a remarkable regulatory role in most eukaryotes. These molecules bind to Argonaute proteins (AGO) and form a complex that recognizes its mRNA targets by sequence complementarity. The regulatory role is driven by the catalytic activity of AGO, but not exclusively. In several organisms, AGO recruits other factors to perform the silencing. Remarkably, during transcriptional gene silencing, the small RNA-AGO complex engages factors that interfere with transcription but also proteins that modify the DNA and the chromatin at the targeted loci. This phenomenon has been observed in plants, yeast, flies, and worms. Particularly, in the nematode Caenorhabditis elegans, this silencing regulation can be triggered and inherited by the next generations. This reveals the importance of small RNAs and chromatin modifications for transmitting non-genetic information and maintaining germline stability across generations.Several factors required for epigenetic inheritance have been identified by genetic screens in the worms. The nuclear Argonaute, HRDE-1, is expressed in the gonad and is a key component of this pathway. Still, what are the HRDE-1-associated factors required for transgenerational transcriptional silencing are not fully understood. This proposal aims to address what are the factors participating in the different stages of silencing mediated by HRDE-1: establishment, inheritance, and maintenance. To answer these questions, I will employ strains that allow the inducible depletion of the factors involved in the silencing response. I will combine these tools with encompassing genomics and proteomic approaches to investigate the changes across generations. This proposal will unveil the molecular mechanisms of transgenerational epigenetic inheritance. Moreover, thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'TWINNING FOR A EUROPEAN CONSORTIUM OF RECTAL CANCER RESEARCH INSTITUTIONS THROUGH STEPPING UP SCIENTIFIC, TECHNOLOGICAL AND INNOVATION EXCELLENCE OF IORS'.

assistant: **Innovation**

Neoadjuvant chemoradiotherapy (CRT) is the gold standard in locally advanced rectal cancer (LARC), but the response is not uniform among patients and improvements are currently being assessed. Profiling the response to CRT in patients with LARC would enable more adequate selection of patients who would benefit most from CRT while minimizing adverse effects and toxicity. Patients with a favorable response to CRT might be candidates for a less invasive surgical approach or for enrollment in a ""watch and wait"" approach in the case of a complete clinical response (cCR). This would increase their quality of life and contribute to the overall reduction of treatment cost. Identification of novel therapeutic targets might also benefit rectal cancer patients who do not respond well to neoadjuvant CRT.The main aim of the STEPUPIORS project is to establish a European consortium of research institutions dedicated to defining prognostic biomarkers in rectal cancer. Specific project objectives that would enable addressing this unmet clinical need are: Objective 1: Determine the molecular profile of response to neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer through a newly formed rectal cancer consortium with complementary expertiseObjective 2: Strengthen the research, management and administrative abilities of the Institute for Oncology and Radiology of Serbia (IORS) located in Belgrade, Serbia along with the establishment of a rectal cancer biobankObjective 3: Establish a long-lasting knowledge, personnel, and sample exchange between participating institutions in the rectal cancer consortium.The STEPUPIORS project aligns with Europes beating cancer plan and the Horizon Europe strategic plan 2021-2024 within the health cluster, through setting up a re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Forecast of Actionable Radiation Belt Scenarios', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Forecast in Space Weather modeling mostly ignore the fact everything is driven by the sun, that is basically unpredictable. Propagating observed solar dynamics to Earth is questionable, it depends on models whose boundary conditions we are incapable of constraining. We are limited to data at L1, giving a one hour lead time and neural net type forecasts of controlling parameters ( e.g. Kp) that govern the physics of our best models. Nowcasts are better: advanced data assimilation techniques with physics based models show great fidelity in reproducing the real radiation belt (RB) environment. Operational use of such Nowcasts is limited by lack of high quality real-time data beyond GEOS.The FARBES project is different:  it limits its ambition to simple, achievable prediction goals that are of utility to satellite operators, while avoiding the pitfalls of past projects. We hold that while it may be impossible to accurately predict the break of a space weather event, once an event has started we have the tools to predict subsequent behavior and to update our predictions during the event. While we may not be able to globally predict in detail the subsequent dynamic behavior, we can provide actionable forecasts for satellite operators on a few key event characteristics:a. Time to most severe environmentb. Most severe Flux reachedc. Time to the end of eventThese characteristics were deemed most useful by spacecraft operator representatives at  ESWW16 [http://www.stce.be/esww13/contributions/public/S5-O1/S5-O1-03-PitchfordDave/FORECASTINGTHEPERFECTSTORM.ppt]. We overcome the data-assimilation nowcast limitations by using physics based models driven by simple, affordable and reliable ground-based real-time inputs only,  we overcome our inability to accurately forecast magnetosphe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of Self-lubricating Nanocomposite Coatings impregnated with in-situ formed MoS2 for Tribological Applications' (NANOCOAT).

assistant: **Concept**

Use of self-lubricated coatings in dynamic contacting parts of the system not only reduces complexity, weight, and cost to the system, but also improves the performance to a great extent by reducing friction and wear. Unlike liquid lubricants, the release of various toxic and harmful chemicals to the environment can also be avoided. So, a self-lubricated surface with a long lifetime is a promising one to meet future challenges. The most common solid lubricants are graphite and transition metals layered dichalcogenides, among which MoS2/WS2 has a great prominence. In this proposal, electrodeposition of Co-W alloys impregnated with MoS2 and WC nanoparticles will be carried out to form nanocomposite coatings by a low cost electrodeposition process. The idea is to impart high hardness and mechanical strength by WC particles for wear resistance; and self-lubrication property by MoS2 particles to a Co-W matrix. Firstly, unlike ELECTROLYTIC CO-DEPOSITION from suspensions of MoS2 nanoparticles, here, emphasis will be on the in-situ formation of MoS2 particles in the electrical double layer followed by their incorporation into Co-W alloys during electrolytic reduction process. Secondly, R&D efforts will be directed to co-deposit WC particles from suspensions along with MoS2 to make self-lubricated wear-resistant nanocomposite coatings. The detailed mechanistic study of MoS2 nucleation and growth; the surface and structural characterization of the nanocomposite coatings, wear and friction property and corrosion will be investigated to understand the structure property correlation. Thirdly, the electrodeposition of Co-W+WC+IF-MoS2 nanocomposite coatings will be carried out from electrolytic suspensions of WC and IF-MoS2 nanoparticles, and the properties will be compared with the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Particles in the upper troposphere and lower stratosphere and their role in the climate system' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

PART will provide better estimates of optical properties, number density, composition, and particle size of aerosols in the upper troposphere (UT) and lower stratosphere (LS), including cirrus. The knowledge gained will improve our ability to calculate the radiative forcing due to aerosol and ice components in the UT/LS and also our ability to predict stratospheric ozone. The project will describe the formation and development of aerosols in the UT/LS using a hierarchy of models. New laboratory data on aerosol optical properties will be used to optimally estimate aerosol properties from existing satellite measurements. The improved observational data will be used to check the quality of the new aerosol parameterisations. Finally, sensitivity and scenario simulations with global General Circulation and Chemistry Transport Models will be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of eco-friendly ironmaking processes based on GPU-enhanced DEM-CFD modelling', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Blast furnaces are widely used in the iron-making industry. The running of blast furnaces consumes 60% energy of whole steel industry and is primarily responsible for the CO2 blueprints in steel plants. As the steel industry is suffering much with the increase iron ore prices and global economy recession in recent years, it has now become a urgent need to adopt innovative approaches to reduce the production cost in iron-making. It is well recognized that the development of eco-friendly steel plants are urgently demanded. DECRON provides a unique and timely opportunity to bring together the fellow’s research experience in the high performance computing, GPU and discrete element modelling (DEM) with the supervisor’s extensive experience in coupled DEM with computational fluid dynamics (DEM-CFD), particle flow, packing and segregation. This will result in the development of novel charging methods for blast furnaces based upon a thorough micro-mechanistic understanding of the process using GPU-enhanced DEM-CFD, and lead to more precision and better controlled charging systems for blast furnaces. DECRON will for the first time devise an indisputable technological innovation and establish feasible strategies to achieve controlled burden distribution in blast furnaces, which will maximise energy efficiency and reduce CO2 emission in iron-making processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated multi-vector management system for Energy isLANDs' in the context of a Horizon 2020 call.

assistant: **Objectives**

Efficient, reliable and sustainable delivery of energy is critical to the health and welfare of all people. Providing a low-carbon, climate resilient energy supply is a global challenge, which is even more demanding in remote areas. With increasing penetration of renewable energy resources (RES), and high expectations from end-users for energy reliability, connectivity and utilisation of available energy resources needs reconsideration. Thus, technologically smart and economically viable solutions for extending the lifetime of energy infrastructure will be in high demand. Incorporating more distributed RES and storage assets at the edges of the electricity grid, and optimally balancing these assets with other energy vectors, while extending the lifetime of current infrastructures will not only be economically viable, but at the same time decrease the level of carbonisation in local energy systems.E-LAND consortium believes that there are still major challenges in connection to technology, society and economics to overcome. In the E-LAND project, the main objective is to tackle these challenges and support the decarbonisation of energy islands by developing a E-LAND Toolbox for Multi-Energy Islands including tools and methods addressing the business, society and technology challenges. Project is going to implement the toolbox and demonstrate the viability and impact of the tools and methods created in 3 real life pilots in Europe and through simulations with 2 cases in India. Pilots have different geography, demography, sociography and maturity in terms of community and end-user activities, implementation of different energy vectors including storage, amount of renewables in the local energy mix and variety of loads that call for efficient and intelligent management syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cultural and genetic variation in emotion regulation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Cross cultural research has revealed differences in the expression and experience of emotions related to individualistic/collectivist (IC) cultural values. The in- versus out-group context and the level of self-relevance of a situation affect these IC differences. Williams syndrome (WS) is a genetic disorder associated with abnormalities in emotional responding. Individuals with WS show heighted emotional responses and amygdala activity to happy faces and fearful/threatening non-social scenes but a reduced amygdala response to fearful faces. Thus, cultural and genetic factors can affect emotional responding in specific situations. Emotion regulation involves the processes by which individuals influence the emotions that they experience and express, and may be related to individual differences in emotional responding. There are notable differences in the neural substrates and effects on emotional responding of different emotion regulation processes used in different contexts. fMRI, EEG, behavioural observation, physiological measurement and self-reported emotional experience will be used to investigate the variation in emotion regulation associated with IC factors. IC variation will be measured at a group level (cultural group comparison), at an individual level (affiliation towards specific IC cultural values) and within individuals (manipulation of the temporary salience of a particular IC value), within the context of spontaneous emotion regulation and instructed antecedent and response focussed up- or down-regulation of positive or negative emotional responses. Variation in emotion regulation associated with the WS genotype will be investigated by comparing individuals with WS to individuals without WS matched on age, socialisation and executive functioning. Regulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Structure of free and complexed IF2 and search for a new target for anti-microbial drugs'.

assistant: **Objectives**

The discovery of new anti-microbial agents has become a problem of crucial importance in light of the acquired resistance of many pathogens to most of the available antibiotics. The new industrial trend in antibacterial R&D is focused on the high through-put screening of select, appropriately chosen, broad spectrum macromolecular targets. In the present programme, we plan to develop a new class of antibiotics directed against bacterial translation initiation factor IF2 or interfering with the interaction of this protein with its main ligand initiator fMet-tRNA, which, unlike elongator tRNAs, is not present in eukaryotes. In fact, IF2 and the IF2-fMet-tRNA complex are endowed with all the properties required by an ideal target for rational drug design. High through-put screening tests will be applied in the search for both natural and synthetic compounds interfering with the various functions of IF2. The positive hits will be subjected to secondary screens and the most promising compounds will be improved by combinatorial chemistry and rational drug design based on the target's 3D structure which, in the meantime, will be elucidated by NMR spectroscopy and X-ray crystallography. Indeed, one of the main aims of this proposal is to characterize the 3D structure of initiation factor IF2, both free and in complex with its ligands (fMet-tRNA and guanosine nucleotides); more precisely, we envisage the elucidation of both crystal and solution structure of the two domains which contain all the IF2 activities required for translation (i.e. the central G-domain containing GTP binding site, GTPase catalytic center, 30S and 50S binding sites and the C-terminal domain containing the fMet-tRNA binding site). The perspectives for elucidation of the 3D structure of IF2, both alone and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Twinning for an Offshore Wind Energy Partnership' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Portuguese Government has approved the Industrial Strategy for Ocean Renewable Energies (EI-ERO) with the aim of developing the country’s offshore wind potential. According to EI-ERO, offshore renewable energies have the potential to supply 25% of the electricity consumed annually in Portugal  and create a new export chain in these new technologies. The government envisages that potential exports in this field could increase up to ten times the current employment in the active sectors, with the greatest potential for exports seen in the development of the floating wind technology.The overall objective of TWIND is to create a network of excellence that will dynamize a pool of specialized research professionals and trainers  in the domain of offshore wind energy to support an emerging industry in Portugal in a field with a very strong anticipated growth and no dedicated existing training curriculum. WavEC will be the pivot research institution of the low performing Member State (Portugal) coordinating efforts with internationally-leading counterparts at the EU level (Spain, UK and The Netherlands) and enhancing its excellence and innovation capacity through the exchange of knowledge with these leading research organizations. The combining capabilities of partners will open the grounds to exploit existing research results and invest in developing more knowledge. These objectives will be fulfilled through a set of strategic activities well-structured throughout the project including specific training programmes on thematic topics, short-term scientific meetings, long-term staff visits, networking meetings, attendance to relevant conferences in the field, knowledge transfer workshops with stakeholders and an annual event.The networking activities and exchange of knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Extending Professional Active Life' (2007-2013).

assistant: **Innovation**

Project ePAL aims to explore innovative ways to best facilitate the development of the active ageing process and to ensure an improved transition for the elderly citizen as they cope with the onset of age. In order to find appropriate ways towards this goal, a strategic RTD roadmap is proposed focused on innovative solutions and ensuring a balanced post-retirement life-style.<br/>The ePAL vision – addressing new levels of quality of life –  is that of an effective transformation of the current situation regarding retirement and the barriers to active ageing in Europe by introducing new approaches and ways to create actively contributing professional communities in society, which provides the elderly citizen with a supporting framework for leverageing their talents and expertise and creates value for the benefit of the Europe's economy. Moreover, such a framework would also support a balanced transition towards retirement. The ePAL vision will do much to place Europe as the leader in promoting active ageing worldwide.<br/>ePAL aims at identifying and characterizing the key research challenges, required constituency, and the implementation model for a comprehensive approach to support in innovative ways the increasing numbers of professional retirees in Europe. ePAL proposes a feasibility study and development of the roadmap covering a comprehensive approach for discovering new ways to promote a balanced active life for retired professionals and a sustainable new notion of silver economy with a wide societal impact.