RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Post-exposure vaccination against hepatitis B', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

1. Objectives  The proposal will investigate the hypothesis that certain chronic persistent infections of humans can be treated by stimulation of the Th1 arm of the specific immune responses, resulting in virus clearance and recovery of the patients. Based on recent data generated from patients recovering from chronic infections with hepatitis B virus (HBV), either spontaneously or after treatment with interferon-alpha (IFN-alpha), we propose to use chronic hepatitis resulting from HBV infection as a model for chronic persistent infections of humans and animals. The findings will have transdisease implications for the treatment of chronic hepatitis C in humans and pestivirus-induced mucosal disease of cattle.  The major objectives of this study are:  1. The development of hepatitis B-specific immune stimulating complexes (iscoms) containing either HBV S, or both S and C proteins;  2. The preparation of plasmid vectors containing the HBV genes coding for the major HBV structural proteins S and C;  3. The assessment of the role of cytokines in HBV clearance by measurement of TH 1- inducing (IL-12, IL-18) and TH 1 (INF-gamma, TNF-alpha) and TH 2 (IL-4, IL-10) effector cytokines in longitudinal plasma samples obtained from chronic hepatitis patients who have resolved their HBV infection following INF-alpha treatment; and  4. An immunological evaluation of different methods of HBV antigen presentation, delivered either in the presence or absence of selected cytokines in order to maximise immunogenicity, including the determination of their TH 1 and CTL promoting capacity, potency and absence of toxicity.  The goal of this study is to provide a rational evaluation of HBV structural proteins delivered either iscoms or as a DNA plasmid, together with selected cytokines, for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Surface material caractheristics on-line" and "off-line" quality-control smac"'.

assistant: **Innovation**

Materials surface characteristics as stone (slabs and tiles) and wood (panels and tiles), commonly utilised to realise manufactured goods, are influenced by their production strategies both in terms of materials utilised and superficial physical-chemical action applied. Both aspects influence final products esthetical characteristics and their quality in terms of durability, cost and processing actions to apply. Until now these aspects have not been scientifically investigated Industrial quality control approaches have been carried out on empirical and human base. Investigations (imaging, spectrophotometer, diffraction, SEM and AFM based) will be carried out, according to different production strategies and tests, to fully understand the physical-chemical characteristics and behaviour of surfaces. The study of such phenomena could reach i) a strong energy saving through the adoption of specific processes and actions avoiding waste of energy during sawing and polishing and reducing consumption of materials (raw materials, abrasives, special tools) ii) the possibility to define classes of quality and to certify the products;iii) to obtain manufactured goods (sabs, tiles, panels) of higher durability for applications; iv) reduction, of polishing costs affecting the final reducing consumption of price of products;v)better working conditions for operators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Providing the right care to the right patient with MyeloDysplastic Syndrome at the right time'.

assistant: **Objectives**

Myelodysplastic syndromes (MDS) are chronic bone marrow malignancies of the elderly, complicated by severe anaemia. MDS significantly affects quality-adjusted survival and it imposes an increasing financial burden on patients and healthcare (HC) systems. The burden of disease is expected to worsen in the future, given the aging EU population and newly identified MDS cases among those diagnosed with ‘Anaemia of the Elderly’. EUMDS - a unique registry with prospective, observational data on 1600 lower-risk MDS patients from 16 EU countries - enables comparison of existing MDS HC interventions (HCI).Objectives1) Comparison of outcomes and costs of existing HCI, using established and new core outcome sets. This, alongside health technology assessment, will provide robust evidence to underpin sustainable use of HC resources;2) Enhanced compliance with diagnostic procedures in MDS by introducing new minimally-invasive diagnostic methods. This will increase the number of correctly and timely diagnosed MDS patients;3) Raised awareness of the relevance of obtaining the right diagnosis in elderly by comparing HRQoL between EUMDS and against a non-MDS cohort. This will improve HRQoL of individual patients through better tailoring of HCI;4) Better outcome predictability of available HCI by refining classification of cases using molecular characterisation to incorporate response to HCI and to provide evidence for personalised medicine;5) Improved, evidence-based, guidelines supporting the regulatory process, and providing information to patients and physicians to promote personalised decisions in MDS care;6) Establishment of a European MDS competence network encompassing all stakeholders in the MDS field.RelevanceBetter treatment compliance, a more evidence-based use of HCI and an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Agile MIMO Systems for Communications, Biomedicine, and Defense' (AMIMOS).

assistant: **Concept**

This proposal targets the emerging frontier research field of multiple-input multiple-output (MIMO) systems along with several innovative and somewhat unconventional applications of such systems. The use of arrays of transmitters and receivers will have a profound impact on future medical imaging/therapy systems, radar systems, and radio communication networks. Multiple transmitters provide a tremendous versatility and allow waveforms to be adapted temporally and spatially to environmental conditions. This is useful for individually tailored illumination of human tissue in biomedical imaging or ultrasound therapy. In radar systems, multiple transmit beams can be formed simultaneously via separate waveform designs allowing accurate target classification. In a wireless communication system, multiple communication signals can be directed to one or more users at the same time on the same frequency carrier. In addition, multiple receivers can be used in the above applications to provide increased detection performance, interference rejection, and improved estimation accuracy. The joint modelling, analysis, and design of these multidimensional transmit and receive schemes form the core of this research proposal. Ultimately, our research aims at developing the fundamental tools that will allow the design of wireless communication systems with an order-of-magnitude higher capacity at a lower cost than today; of ultrasound therapy systems maximizing delivered power while reducing treatment duration and unwanted illumination; and of distributed aperture multi-beam radars allowing more effective target location, identification, and classification. Europe has several successful industries that are active in biomedical imaging/therapy, radar systems, and wireless communications. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'GReen Energy Transition Actions' (GRETA) under Horizon 2020.

assistant: **Objectives**

The GRETA project aims to improve understanding on the conditions and barriers for energy citizenship emergence. Energy citizenship has come to represent a form of active participation within energy systems that ultimately supports local and global decarbonisation goals. It can manifest in many different ways, such as individual homeowners choosing renewable energy solutions or electric vehicles, participation in energy communities, or advocating for climate change. But not everyone has the possibility to participate. This can be due to a range of factors, including being unaware of issues or their practical solutions; being excluded from debates and decision-making; being prevented from taking action due to lack of resource or lack of power. Through a multinational survey and six participatory case studies, GRETA will develop frameworks and models aimed to reveal what factors affect energy citizenship. These will be utilized within case studies to identify problems, frame solutions and reach consensus on roadmaps for change, formalized through Energy Citizenship Contracts. Findings throughout the project will be utilized to inform and encourage policymakers to advocate energy citizenship.


**Keywords:** energy citizenship, participation, decarbonisation, models, inclusion, policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of gene regulation by pdgf using microarrays' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The aim of the present project is to analyze gene expression in normal human fibroblasts stimulated with platelet-derived growth factors (PDGFs) using the DNA micro array technology. The target genes will be connected with signaling cascades and PDGF activities. Preliminary experiments indicate that PDGF regulates a group of genes involved in cholesterol metabolism. This observation, which was confirmed by RT-PCR, suggests that PDGF might stimulate membrane synthesis and modify its composition and fluidity. Our data also suggest that the SREBP transcription factor is responsible for this effect. Using a dominant negative variant of this factor, we will assess the role of cholesterol synthesis stimulation by PDGF for fibroblast proliferation and migration. The importance of SREBP activation by PDGF in tumor cells, which have an altered lipid metabolism, will be investigated in vitro and in vivo. Cholesterol metabolism regulation by PDGF could also contribute to atherosclerosis, a process in which PDGF is known to play a important role. We will test this hypothesis using apolipoprotein E-deficient mice, a well characterized model for this disease. We hope to identify other interesting groups of genes relevant to PDGF activities. In summary , this project will focus on a new aspect of PDGF function and could have some consequences on the understanding and the treatment of diseases that involve PDGF.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of activation-induced cytidine deaminase in inflammation-induced carcinogenesis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Activation-induced cytidine deaminase (AID) is a DNA-modifying enzyme essential for somatic hypermutation and class switch recombination in B cells. However, deregulation of AID can induce mutations and chromosomal translocations in B cells thus promoting neoplastic transformation and cancer development. AID expression is controlled by several transcription factors like those of the Rel/NF-kappa B family. The NF-kappa B pathway can be activated by a variety of different stimuli and constitutive activation of NF-kappa B is implicated in various malignancies. Indeed, the well established link between chronic inflammation and cancer has been correlated to constitutive NF-kappa B activation by inflammatory cytokines. Although the expression of AID was originally thought to be restricted to B cells, it has been shown recently that stimulation with inflammatory cytokines also induces AID expression in different epithelial cells. Furthermore, expression of AID has been found in hepatocarcinomas, gastric cancer and bile duct carcinomas suggesting a link between inflammation, NF-kappaB activation, AID expression and cancer development. However, it remains unclear if in the observed cases AID expression is just a by-product of NF-kappa B activity or if AID actively contributes to cancer development and/or progression in vivo. In the proposed research project, I am aiming to address the role of AID in the development and progression of carcinomas in vivo. For this purpose, I am going to compare the tumour incidence and aggressiveness between wt and AID-/- mice in a model for colitis-induced carcinogenesis. In addition, I am planning to generate a reporter system in which the expression of the oncogenic KRasV12 mutant depends on the reversion of a STOP codon by AID. This will decre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Distinct Infection Dynamics and Ecological Success among Closely Related Marine Cyanophages: Why the Differences?' (PhageDiff).

assistant: **Concept**

Viruses are extremely abundant in the oceans and majorly impact the marine ecosystem by influencing the abundance, diversity and evolution of their hosts. However, our understanding of marine viral physiology and ecology among different members of the virus community is conspicuously lacking. Preliminary data using a newly developed molecular method revealed drastic differences in field abundances of two subtypes of T7-like podoviruses that infect marine cyanobacteria. Moreover, these subtypes displayed large differences in infection properties in laboratory studies. The main objective of this proposal is to gain a deep understanding of the genetic basis for the physiological differences in infection dynamics among closely related T7-like cyanophages that infect the globally important marine cyanobacteria, Synechococcus and Prochlorococcus, and to ascertain the ecological consequences of these physiological differences. We hypothesize that a small set of genes, beyond the core replication and morphogenesis genes, differentially impact the dynamics of the infection process which, in-turn, defines the niche occupied by discrete members of this virus family. Our specific objectives are to identify the genes responsible for the physiological differences and determine their impact on infection dynamics. This will be achieved through the development of a phage gene inactivation system and the comparison of infection properties of mutant and wild-type phages. Furthermore, using our new molecular field method, we will assess the distribution patterns of different subtypes of T7-like cyanophages from within the mix of all viruses in the oceans. The unique combination of innovative molecular methods with physiological experimentation and ecological sampling will provide significa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A 100% sustainable and infinitely scalable electrical energy storage system' under Horizon Europe.

assistant: **Concept**

AquaBattery is a revolutionary battery storage technology that offers unlimited storage capacity, inexpensive scaling and is 100% sustainable. AquaBattery is based on a simple principle: input renewable energy, store it in seawater, then return electricity when there is energy demand. The core innovation is the use of seawater as a sustainable, safe and scalable energy storage medium. This is enabled by the company’s patented membrane stack technology that utilizes bi-polar membrane electrodialysis and reverse electrodialysis for energy storage and discharge. During the charging phase, saltwater flows through the membrane stack and produces an acid and base stream that is stored in tanks. During discharge, the solutions flow back through the membrane stack to generate salt water and release energy. With this disruptive solution, AquaBattery aims at revolutionizing the energy storage world, fostering the growth of renewable energy technologies and stopping the use of toxic materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Automation and INtelligence solutions for Automated Road trAnsport systems' (AINARA), addressing dissemination and exploitation.

assistant: **Impact**

With an expertise of the highest European level in robotics, +10 years of experience in the field of autonomous vehicles and several proofs of concept in operational environment (TRL6/7), RDS (spin off of ROBOSOFT) is the only European company to master all of the software components allowing Autonomous Road Transport Systems to reach the levels of robustness and reliability required for passenger transport.Without waiting for the legal framework, which is being implemented thanks to the efforts of the CityMobil2 project, the market study conducted as part of the TAXISAT project revealed that the 1st wave of user demand would emerge in Europe in 2015 for autonomous transport services in pedestrian city centres and private sites such as industrial or theme parks. These markets will grow even faster that the vehicle manufacturers, Transport Organising Authorities or Operators will be able to adapt their services to future mobility challenges. For this, they will need key skills in robotics, intelligence and fleet management. RDS has the means to satisfy them by providing off-the-shelf ARTS AUTOMATION and INTELLIGENCE solutions. Current solutions are highly customized in an engineering mode and are not compatible with a wider uptake of its technology. To take a solid position on the emerging global autonomous vehicles market and acquire an industrial dimension, RDS is convinced that best strategy is to deliver Commercial Off-the-Shelf software packages, which will offer recurring revenues and promising growth and profitability prospects thanks to software licences sales.The objective for RDS is now to industrialise its software offer, to be fully compliant with the new EU Directive under development and to test the relevance of the associated business model with the ultima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Enabling Targeted Fractionation of Ions via Facilitated Transport Membranes'.

assistant: **Concept**

Effective fractionation of ions does not only play a vital role in the functioning of human cell membranes, but also in engineered membranes used to produce drinkable water, extract target minerals and capture energy to address challenges in environmental, resource & energy fields. Nevertheless, most of the state-of-the-art membranes fail to overcome the trade-off between single ion selectivity and throughput. The progress is greatly hampered by the lack of comprehensive understanding on the separation mechanisms across different types of as-claimed ion selective membranes. The IonFracMem project will make breakthroughs by designing novel facilitated ion exchange membranes using an interdisciplinary approach based on electrochemistry, which synergizes with the interaction between target ion and functional materials to form ion selective sites in the membrane and thus facilitate its transport. To achieve a holistic understanding, we will purposely construct two types of membranes with completely different structure for fractionating ions: 1) polymeric membranes of flexible nature, made of conventional or hydrogel polymers (Obj. 1); 2) composite membrane of rigid nature, consisting of nanomaterials with sub-nanometer cavities (Obj. 2). Subsequently, we will provide mechanistic understanding of the facilitated transport phenomena via a multi-scale modelling approach (Obj. 3), to identify governing mechanisms that can be translated to membrane fabrication parameters. The project integrates several key engineering & science disciplines such as separation technology, material processing and functionalization, electrochemistry and fundamental physics, allowing rational design of next generation membranes from a wide range of materials for ion purification. The proposed multidi