RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rebalancing the brain:Guiding brain recovery after stroke' (BRAINBALANCE).

assistant: **Concept**

Damage to parietal cortex after stroke causes patients to become unaware of large parts of their surroundings and body parts. This so-called spatial neglect is hypothesised to be brought about by a stroke-induced  imbalance  between the left and right hemisphere. Some patients experience a partial recovery of lost abilities, but the factors that drive this  rebalancing  are unknown. The research proposed here will overcome this bottleneck in our understanding of the brain recovery phenomenon, and develop therapeutic approaches that for the first time will control, steer and speed up brain rebalancing after stroke. To that goal, we introduce a revolutionary approach in which TMS, fMRI, and EEG are applied simultaneously in healthy human volunteers to artificially unbalance the brain, and then study and control processes of rebalancing. Because we are one of the few groups worldwide that has accomplished this methodology, and that has the expertise to fully analyse the data it will yield, we are in a unique position to deliver both fundamental insights into brain plasticity, and derived new therapies. In brief, we will use TMS to (i) mimic spatial neglect in healthy volunteers while simultaneously monitoring the underlying neural network effects using fMRI/EEG, and to (ii) determine which exact brain reorganisation leads to an optimal behavioral recovery after injury. Importantly, we will use cutting-edge fMRI pattern recognition and machine learning algorithms to predict which concrete TMS treatment will specifically support this optimal functional reorganisation in the unbalanced brain. Finally, we will directly translate these fundamental findings into clinical practise and apply novel TMS protocols to rebalance the brain in patients suffering from parietal stroke.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Monoamine oxidase B inhibitors as novel drugs targeting NLRP3 inflammasome' to be submitted under Horizon 2020.

assistant: **Abstract**

Although the number of anti-inflammatory drugs has increased during the past decade, there is still an urgent need to develop novel alternatives that overcome limitations of current treatments. The most used therapies, such as non-steroidal anti-inflammatory drugs, non-analgesic anti-inflammatory drugs or colchicine, often present severe side-effects. In addition, in recent years biologicals have appeared, but they are extremely expensive. Therefore, novel therapeutic approaches with lower toxicity, higher tolerance and lower price must be developed to treat autoinflammatory and autoimmune diseases. Since the NLRP3 inflammasome is a key contributor of inflammatory diseases (including gout, pseudogout, metabolic arthropathies and multiple sclerosis), its targeting has become very relevant for the development of novel therapeutics. As part of our ERC project STePS, we discovered a novel activation pathway to the NLRP3 inflammasome, which opens new opportunities to use an existing line of compounds for radically new medical indications. Within STePS, we uncovered the activation of the NLRP3 inflammasome by the enzyme Monoamine Oxidase B (MAO-B) through ROS production, positioning MAO-B as a promising target to treat autoinflammatory and autoimmune diseases. Given that there are several MAO-B inhibitors (iMAO-B) currently used in the clinic for treatment against Parkinson disease, the use of iMAO-B represent a major opportunity to develop new therapies at low risk and a fraction of the cost. This ERC PoC MOBILISE will assess the technical and commercial feasibility of repositioning iMAO-B as a novel treatment of gout and other NLRP3 inflammasome-driven diseases. Within MOBILISE, we aim to explore the efficacy in vivo of iMAO-B, solidify our IP protection, perform an extensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Multimedia Content Annotations for Rapid Exploitation in Multi-Screen Environments'.

assistant: **Innovation**

The objective of MECANEX project is to devise innovative tools for automatic annotation and editorial support of multimedia content, extraction of personalized information and adaption of enriched multimedia content in multi-screen environments. As the prerequisites of production houses, broadcasters, advertising agencies and online publishing companies for enriched multimedia content increase rapidly, the need of such innovative tools is undeniable. Furthermore, the adaption of enriched multimedia content to multi-screen environments, which enable the automatic porting to different target platforms, such as regular web pages, mobile pages and mobile apps, as well as TV applications, is a significant asset for the global market of enriched multimedia content. The major novelty of MECANEX is the creation of SaaS (REST based) toolkit that provides the aforementioned functionalities by bringing together complementary expertise and technology of different European companies and research institutes, in order to provide a cost effective multi-screen video metadata enrichment solution for SMEs. Such tools will be adopted by production and post-production companies, as well as by content providers or relevant service oriented companies and will be adapted into the creation process. MECANEX will offer SMEs to semi automatically enrich video collections for multi-screen application, as well rapid prototype multi-screen concepts and test related interaction models that eventually will improve the chance for SMEs to develop more solid business models, marketing and advertising campaigns. Furthermore, a social and personalization tool is envisioned, which will collect consumers’ preferences and will provide feedback to the aforementioned tools. In a nutshell, automatic annotation, e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Probiotic-based Ophtalmologic treatment for Bacterial and Allergic Conjunctivitis' to be submitted under Horizon 2020.

assistant: **Abstract**

Conjunctivitis is a major health issue affecting more than 1100 million people worldwide. Currently, the market for bacterial & allergic conjunctivitis is mainly covered by antibiotic eye drops and ointments, which have undesired effects in the eye microbiota and contribute to increase the resistances of pathogenic strains. Other treatments such as anti-inflammatory and antihistaminic drugs have also undesired side effects and are not useful as an immediate solution.AB-BIOTICS, a company with a broad expertise in developing functional ingredients for the pharmaceutical industry, has developed an innovative solution based on the use of probiotics. Probiotics are live micro-organisms allowing a fast and stable reestablishment of a healthy eye microbiota by providing: (1) faster anti-inflammatory and anti-histaminic effects; (2) antagonism to pathogens with no resistance risks; (3) protection against future/recurrent infections; and (4) avoidance of common side effects such as intraocular pressure rising.The effects of the selected probiotic strains have been validated through functional in vitro and in vivo tests and its safety for ocular application has also been assessed in toxicity trials in animal models. The industrial scaling up of the strain has already been achieved and is now ready for galenic formulation.In order to determine the key steps to bring PROBIOTEARS to the market within the next 2 years, the objectives of the presented feasibility study are:• Assess clinical ophthalmologists & users associations interest• Determine the most suitable formula for ophthalmic use• Define IPR strategy• Perform a deeper market & competitor analysis• Find key partners to carry out Supportive Clinical Trials in phase 2• Assess Regulatory RequirementsPROBIOTEARS is a solid hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'How Terrorism Ends: A Comparative Analysis of Underground Organisations in Italy and Spain' (HTE) under Seventh Framework.

assistant: **Objectives**

This project analyses the conditions under which terrorist groups fall into decline. This is done through a systematic comparison of different paths of disengagement and exit from terrorism that have concerned different types of (a) Left-wing (b) Nationalist-Separatist, (c) Religious-Fundamentalist and (d) Right -wing terrorist groups in two European democracies (Italy and Spain) in the last 40 years (1970-2010). Many scholars have noted the cyclical nature of terrorist movements. However, scarce attention has been paid so far, within academia and outside it, to the ways in which such groups come to an end or move away from violence. Referring to social movement studies, and adopting a ‘dynamic approach’ to the study of disengagement, my research project seeks to answer these questions. It discusses the possible paths for leaving underground organisations, specifically interrelating the micro-meso-macro analytical level of analysis, exploring how the complex interactions between the social, political, and cultural environment, combined with the internal dynamics of the groups, affect the exiting from terrorism. This will be done by adopting a methodological triangulation strategy which combines a ‘large N’ quantitative study with a ‘small N’ comparative case study of different types of ‘disengaged’ terrorist groups, and several qualitative-quantitative data-collection techniques: compilation and analysis of a selective data base of underground organisations; discourse analysis of interview data; content analysis of historical records (newspapers, government documents, autobiographies, documents from organisations); and systematic consultation of secondary sources. Focusing on different contexts and different kinds of movements (Right-wing, Left-wing, Ethno-nationalist a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Engineering a bacterial toxin alpha-hemolysin with Vitamin B12: Single Molceule Catalysis in the alpha-hemolysin nanoreactor' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal describes a novel strategy for the embedding of vitamin B12 into a nano-sized protein reactor, in order to study the mechanism of reductive dechlorination reactions. This work will be the first study to observe catalysis in the alpha-hemolysin nanoreactor and will pave the way to the design of new biologically friendly catalysts for the degradation of harmful poly-chlorinated pollutants. In the experimental apparatus, preformed pores, (Staphyloccocal alpha-hemolysin) will be introduced into planar bilayers by adding small amounts of the pore protein to one chamber. Reactions are monitored by recording the modulation of the ionic current that flows through an individual pore at a fixed applied potential in millisecond time scale. The observation of catalysis in the engineered pores is our aim to provide new opportunities to examine mechanistic steps that might be missed in ensemble measurements by known techniques. We propose to insert super reduced vitamin B12 (cyanocobalamin) into alpha-hemolysin pore under anaerobic conditions. This will yield a functional nanoreactor, which can be considered as a biosensor, to detect very small amounts of contamination of chlorinated waste molecules in the environment, as well as serve as a platform for single molecule studies. These experiments will shed light into the proposed reaction mechanism on reductive dechlorination of poly-chlorinated ethenes at a molecular level of detail. Understanding the steps of the carcinogenic vinyl chloride; VC formation will provide the knowledge to construct environmental friendly, “cell free” catalysts to prevent the accumulation of these carcinogens in the environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Generic and Highly Organic, Shape-changing inTerfaces' under Seventh Framework.

assistant: **Concept**

Current user interfaces for computers and mobile devices often separate input and output, are typically static in their physical appearance, and rarely tap humans' ability to reason about and manipulate physical objects. We propose a new paradigm of interfaces that address these limitations. The paradigm is called Generic and Highly Organic, Shape-changing inTerfaces (GHOSTs). GHOSTs are display surfaces made of malleable materials that can change into and retain arbitrary shapes so as to display output from the system or afford new actions. At the same time, GHOSTs allow users to deform, touch, or otherwise manipulate the shape of their display surface to provide input to the system. We argue that such interfaces provide many benefits over current user interfaces by leveraging humans' ability to perceive, express, and communicate through touch and manipulation of physical objects.The present project will design, develop, and evaluate GHOST prototypes. We combine disciplines focusing on (a) the hardware and software for shape change, using combinations of shape actuators and smart materials; (b) the industrial and interaction design for such interfaces, in particular how to make them physically appealing, useful, and usable; and (c) the user experience of interacting with GHOSTs, quantifying and modeling users' performance with and affect towards the interface. These disciplines are brought together in four iterations of prototypes, continuously testing and refining the prototypes' resolution, the shape-change response, users' performance, and the experience of interaction. In addition to the proof-of-concept prototypes, we establish the technical and scientific basis for useful and usable shape-changing interfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Stimuli-responsive theranostic nanogels based on hyperbranched polyglycerol', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Recent advances in medicine and biotechnology have prompted the need to develop nanoengineered delivery systems that can encapsulate a wide variety of novel therapeutics. Moreover, these delivery systems should be “smart”, such that they can deliver their payload at a well-defined time, place, or after a specific stimulus. The ideal drug delivery system should be biodegradable and biocompatible, should benefit from an active and passive targeting, should target only the desired cells, and should release its cargo (high loading capacity) at the desired intracellular space. In addition, recent trends in nanotechnology have developed the concept of theranostic, i.e., imaging, therapeutic and diagnosis in one. To date, only a few examples of nanocarriers that fulfil all of these criteria have been reported and therefore this research field still remains almost unexplored. In addition, the application of all these concepts to polymeric nanogels constitutes nowadays a challenge, and the achievements of the proposed objective will pave the road for future biological and biomedical applications of these polymeric systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nose Fuselage/Cockpit Dynamic Characterization for Internal Noise Attenuation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The research work described in this proposal shall involve detailed simulation of the acoustic performance of CFRP nose fuselage design, and a comparative analysis of a conventional metallic design.The physical properties of CFRP structural components gives a different vibroacoustic response compared to metallic structures. In particular the low material damping and reduced number of mechanical joints made possible by CFRP technologies can give rise to higher noise levels in the cockpit.The work envisaged here shall be conducted by using the software package VA One, which is capable of simulating the response of vibroacoustic systems across the full frequency range. In this project AOES proposes to use the FEF/FEM and FEM/BEM capabilities of VA One. AOES already possesses a license for the VAOne software and has engineers trained in its use.It is expected that the acoustic noise assessment conducted in this project will form input to the Topic Manager and/or ITD leader for improving the design of the fuselage nose and cockpit for superior acoustic performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Hybrid modelling for hydrogen combustion: Accelerating LES with adaptive uncertainty-aware LEM and neural ROMs'.

assistant: **Innovation**

Reaching climate neutrality by 2050 requires deep decarbonisation of transport, industry and other energy-intensive sectors where fossil fuels still dominate. Hydrogen is a zero-carbon energy carrier whose safe, efficient use depends on fast and trustworthy predictions of turbulent flames. For large-scale devices, however, high-fidelity Large Eddy Simulation (LES) is costly because hydrogen combustion couples multiscale turbulence with differential diffusion and intermittent local ignition and extinction. H2SAFIRE proposes a hybrid modelling framework that couples LES with a Linear Eddy Model (LEM) for micro scale chemistry and a Reduced Order Model based Deep Neural Network (ROM-DNN) surrogate trained on LEM data. The surrogate replaces the costly chemistry step when reliable; a calibrated uncertainty gate monitors confidence at run time and reverts to LEM whenever uncertainty exceeds a threshold, preserving physical fidelity.The project pursues three objectives. First, design and validate an adaptive LES-LEM solver tailored to hydrogen combustion. Second, construct a physics-guided LES-LEM-ROM-DNN framework in which ROMs compress LEM outputs and a DNN predicts modal dynamics in loop to supply sub-grid source terms. Third, evaluate accuracy, robustness, generalisation and efficiency on canonical and semi-industrial flames, targeting at least a ten-fold speed-up at matched fidelity. Validation uses a jet-in-hot-coflow flame and an industrial-like furnace. H2SAFIRE will release an open solver, FAIR datasets, benchmark cases and practical guidelines for hydrogen combustion simulations. By enabling faster and reliable predictions, the project can lower modelling cost and energy use, support cleaner industrial heat and transport, and strengthen European capability for hydro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exploitation of the connections from X-ray binaries to active galactic nuclei', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Accretion onto compact objects and the associated jets seem to be ubiquitous in our Universe and also play an important role in the regulation of the growth of galaxies. One can study this accretion process well in the stellar case: X-ray binaries (XRBs) are nearby and have well observable outburst timescales. In his previous Marie Curie fellowship the applicant developed and refined scaling relations between these stellar cases and the supermassive black holes in the centres of galaxies (active galactic nuclei – AGN). In the current project these scaling relations should be used to scale properties of XRBs to AGN to study the feedback phenomenon regulating the growth of galaxies. Concretely, we propose to refine the empirical models for accretion and to apply them to AGN by measuring and modelling galaxy luminosity functions. In the present proposal we suggest to fund a visitor programme and some travelling funds to connect the different European institutes leading the research on compact objects.