RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering cellular and molecular mechanisms of β-cell regeneration' to be submitted under Horizon Europe.

assistant: **Abstract**

Glucagon-like peptide 1 (GLP-1) therapy was shown to regenerate β-cells in mice, but this did not translate to human. Early or intensive insulin therapy maintains residual β-cell function, but also causes weight gain and hypoglycaemia. Thus, currently no drug treatment can safely stop the progression of diabetes, a disease characterized by loss or dysfunction of insulin-producing β-cells.In breakthrough discoveries we identified the insulin inhibitory receptor (inceptor) as a druggable target for β-cell insulin sensitization and protection without the side-effects of insulin. Moreover, we combined GLP-1-mediated safe β-cell delivery of estrogen together with 60% reduced insulin therapy to restore β-cell function for diabetes remission. The overarching goal of BetaRegeneration is to explore new avenues of targeted and combinatorial β-cell protection and regeneration therapy.In Aim 1 we will reveal whether inceptor, beside desensitizing the insulin receptor, has also a function as insulin receptor in starvation/stress-induced insulin degradation and as scavenger receptor for insulin lysosomal degradation. This will reveal if inceptor can be targeted to enhance β-cell insulin sensitization, secretion and function.In Aim 2 we will translate our basic findings to in vivo animal and human model systems to explore GLP-1-mediated β-cell delivery and targeting of WNT and β-cell insulin/IGF1 signaling to enhance specificity and target several pathways at once. Furthermore, we will genetically and pharmacologically target inceptor and test if monoclonal antibodies alone or as drug conjugates can promote β-cell protection and regeneration. Our approach will reveal if combinatorial targeting of survival and regenerative pathways can stop β-cell loss and dysfunction.Taken together, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Chromatin targeting and remodelling by bacterial effectors in plant immunity'.

assistant: **Objectives**

In nature, plants are challenged by disease-causing pathogens such as viruses, bacteria and fungi. Understanding mechanisms of plant disease and disease resistance is of fundamental importance to sustainable agriculture and human health. Unlike mammals, plants lack a circulating immune system. Plants instead rely on the innate immune capacity of each cell and systemic signals that disseminate from infection sites. Successful pathogens use effectors to suppress plant immunity and cause disease. Plants have evolved disease resistance genes encoding immune receptors that perceive specific pathogen effectors to mount effector-triggered immunity. In Arabidopsis, a heteromeric pair of intracellular immune receptors forms a functional recognition complex which senses virulence activities of two structurally unrelated bacterial effectors at the nuclear chromatin.  Results suggest that effector targeting of histone modifications and chromatin remodelling interferes with host basal immunity and that this is transduced by the receptor pair to activation of defence pathways. The underlying molecular mechanisms remain unclear. We have found that the two bacterial effectors interact with an overlapping set of chromatin-associated proteins and with certain immune receptor domains. We hypothesize that the effectors converge on the same chromatin machinery for promoting disease and that their actions are intercepted by the immune receptor system which is physically connected to basal immunity signalling components. By using the effectors as molecular probes, this proposal aims to elucidate how the chromatin environment is modulated during infection and how effector perturbations are converted to effective immunity.


**Keywords:** innate immunity ,  pathogen effectors ,  NLR receptors ,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Market and Trade Policies for Mediterranean Agriculture: the case of fruit/vegetable and olive oil' (MEDFROL), addressing dissemination and exploitation.

assistant: **Impact**

Agriculture is a significant economic activity in the Mediterranean basin. For millennia, the cultivation of fruit and vegetables and olives has been of fundamental importance in Mediterranean culture. The proposed project will analyse the macroeconomic environment and the agricultural sector of the thirteen Mediterranean, non-EU countries, namely Malta, Turkey, Morocco, Algeria, Tunisia, Egypt, Cyprus, Lebanon, Libya, Syria, Israel, Gaza Strip and West Bank, Jordan.More specifically, the project will:Provide a quantitative and qualitative insight of their agricultural sectors with analytical and up-to-date descriptive statistics, presentation of national agricultural policies and description of relevant supply chains."Compare the fruit/vegetable and olive oil sector in these regions with EU countries that produce similar products and stipulate their future course"Provide analytical tools for assessing potential impacts of trade liberalisation with the EU by applying four different models."Evaluate the consequences of trade liberalisation on EU as a whole (consumer prices, market effects, budget burden) as well as on individual Member States and generate appropriate policy recommendationsTo achieve these objectives, multidisciplinary analysis will be applied. Productivity and efficiency analysis will allow the assessment of efficient and inefficient application of technology in the production of fruit/vegetable and olive oil. Consumer demand analysis will be conducted in the European market so as to analyse Mediterranean countries' export performance and determine future trends and possible impact on EU producing countries.Additionally, a trade model incorporating policy effects will be constructed in order to assess likely impacts of a free trade area between the EU an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New machine for producing ice slurry at -35 c for a complete environmentally friendly refrigeration system' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The European legislation has made imperative to respect Montreal 1987 and Kyoto 1997 protocol (Ozone depletion, Total Equivalent of Warming Impact) especially in the refrigeration system regarding the use of CFC (banned), HCFC (banned in 2008) and HFC (to be decreased to a minimum use). Therefore, this project aims to develop a machine able to produce Ice-slurry at -35°C composed of a water solution with fine ice particles ( in replacement of CFC, HCFC and HFC refrigerant) for a complete refrigeration loop.Scientific objectives are:1 To reduce the use of HFC (by a factor of 10 for a complete direct expansion installation) to the minimum level.2 A significant gain in energy efficiency (about 20%) compared to the use of single phase secondary refrigerant.3 A reduction and optimisation of energy consumption thanks to the storage of the ice-slurry during off-peak electrical periods.4 A system cheaper to set up and smaller due to the reduction of the transporting tube section (divided by 5)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Universal properties of Chaos and Hydrodynamics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Fluid dynamics is an effective description that applies to a variety of physical systems such as the quark-gluon plasma produced in heavy-ion collisions at RHIC and LHC. Recently, it has become of foremost importance to develop a hydrodynamic theory that incorporates the effects of statistical thermal fluctuations of the background. With such a framework at hand, it would be possible to analytically access many physical situations where statistical fluctuations are dominant such as in turbulent flows and, for example, around the putative critical point in the phase space of Quantum Chromodynamics (QCD) at finite temperature and finite baryon density. Another place where such considerations become relevant is in the physics of Quantum Chaos. Recent developments have shed new light into manifestations of many-body quantum chaos and have lead to the formulation of an effective theory for chaotic systems, albeit with a large number of degrees of freedom. Deviations from this limit seem to strongly indicate the necessity of including statistical fluctuations. Understanding these effects would help to classify the different universality classes of chaos to complete the survey of its manifestations.The research proposal “UniCHydro” addresses several strategic aspects mentioned above related to universal properties of fluid dynamics and quantum chaos. The Experienced Researcher is an expert on Schwinger-Keldysh effective field theory techniques which constitute the starting point for developing this research proposal. The stimulating environments of MIT and the University of Florence will allow then the Experienced Researcher to acquire the new set of skills in analyzing statistical fluctuations and new competencies in quantum chaos which will be fundamental to enhance its care
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Access to Commercial Services Through the EOSC-hub' (OCRE) targeting Horizon 2020.

assistant: **Abstract**

The Open Cloud for Research Environments consortium combines the expertise of four partners to enable access and drive the adoption and use of commercial digital services by the European research community. Essential for interdisciplinary research, these services include:• Commodity type commercial digital services, such as:      •Infrastructure as a Service (IaaS) and Platform as a Service (PaaS), providing compute, storage, network and related services, and a         platform allowing customers to develop, run, and manage applications as a public cloud service.      •Software as a Service (SaaS), an on-demand software licensing and delivery model in which software is used by the customer on a         subscription basis and is hosted by the supplier as a public cloud service. File storage (sync and share), online collaboration,         simulation and virtualisation tools are example services.• Secure Earth Observation commercial services, which make use of the Copernicus Data and Information Access Services (DIAS).After gathering user requirements, the OCRE will manage the adoption funds and buy resources from the selected suppliers (OCRE will act as customer) and make cloud resources available to institutions. Such a delivery vehicle is effective and efficient for the supply as well as the demand side.Service adoption is the key focus of this work. A legal and technical mechanism (The OCRE Business Management Platform) will be created to integrate a range of these commercial services into the EOSC hub in order to make them more easily available to researchers.


**Keywords:** open, cloud, research, researchers, digital, on-demand, interdisciplinary, Earth Observation, IaaS, PaaS, SaaS, tools, hub, aggregation, interoperability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Transforming Weather  Water data into value-added Information services for sustainable Growth in Africa' in the context of a Horizon 2020 call.

assistant: **Objectives**

Objectives: Provide currently unavailable geo-information on weather, water and climate for sub-Saharan Africa by enhancing satellite-based geo-data with innovative in situ sensors and developing related information services that answer needs of African stakeholders and the GEOSS community.Concept: A systematic feedback loop to reciprocally validate in situ measurements and satellite data in one integrated model. Over 500 in situ measurement stations using citizen science. State of the art advancement & Innovation potential: Building on and pushing further recent advances in sensor and communication technology to provide cheaper and more robust in situ measurements covering a wider area at a higher resolution in sub-Saharan Africa.Working with tech-hubs in Europe and Africa to feed creation and growth of European and African start-ups that develop sensors and geo-services, delivering complete value chains from sensor to customer-ready information delivery.Impact on call expectations:  -Integration of in situ components into models based on GEOSS and Copernicus data-OGC compliant science-grade geo-data (atmosphere, hydrosphere, biosphere) delivered to GEOSS, incl. near-real time statistically characterized soil moisture data from Africa that can be used operationally (not currently available) and radar derived soil moisture measurements also available under cloudy conditions, or vegetation overgrowth-at least 20 new products for use in food, water, energy security, climate change and resilience to natural hazards validated and ready for large-scale implementation by consortium partners and external stakeholders-based on at least 10 innovative, cost efficient, robust, sensors, including fast neutron coun-ter, track¬ing of convective storms with consumer lightning sensors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Euro summer school field theory of quantum coherence, correlations, and mesoscopics' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The proposed Summer School in condensed matter theory aims to present a comprehensive course in field theory techniques and their application to recently discovered physical phenomena and exciting surprises found in novel micro- and nano- structured materials and devices. The forefront of fundamental research in condensed matter has now reached the level where the interplay between many-body correlations, quantum interference and disorder has become the key issue, and field theoretical methods represent the most prominent analytical approach to this class of problems.The new phenomena in the focus of the School include Bose-Einstein condensation of atomic gases and the metal-insulator transition in two-dimensional high mobility electron structures. Other systematic lecture courses will encompass theories of the Luttinger liquid of electrons in carbon nanotubes, the Kondo effect in quantum dots in the Coulomb blockade regime, quantum chaos in ballistic and disordered electronic microstructures, quantum transport in hybrid metal-superconductor- ferromagnet devices, and theories of photonic materials. Theoretical courses will be complemented by a broad overview of advanced experiments in these fields given by world-leading experimentalists.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Eddy viscosity for turbulent flows' (1994-1998).

assistant: **Innovation**

Direct numerical simulation of two and three dimensional fully developed turbulent flows is one of the basic research activities in computational physics. In most cases, for practical applications, one would like to introduce an effective viscosity aimed at simulating the small scale dynamics on large scale flows. The main challenge stems on the idea of reducing the computational problem in a way suitable for present supercomputers. Actual modelizations of small scale statistics are mainly based on pure phenomenological ideas. Eddy viscosities used in Large-Eddy-Simulations for three dimensional flows derive from simple closure ansatz on the statistics of energy transfer. The existence of an intermittent energy transfer leads to the necessity of revising classical modelizations based on the Kolmogorov 1941 Theory. The aim of this project is to combine ideas coming from multiple scale definition of eddy viscosity and recent results by using Extended-Self-Similarity for determining scaling laws in turbulence, in order to analyze in deep details for the first time, the effect of suitable eddy viscosities in numerical simulations. The equip of Prof. Uriel Frisch at the OCA is one of the most active European group in these fields. In particular, we intend to use two and three dimensional numerical codes to test quantitatively the degree of intermittency introduced by using more rigorous mathematical definition of eddy viscosity (by multiple scale analysis) and a rather accurate estimate of anomalous scaling using the concept of Extended-Self-Similarity. This research area is under active investigation in the scientific community for the potential revenue of engineering applications and in particular for the automotive and aeronautics industrial applications. Among the possib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'COMBINING APPROACHES FOR PHOTOSYNTHETIC IMPROVEMENT TO ALLOW INCREASED SUSTAINABILITY IN EUROPEAN AGRICULTURE' (CAPITALISE).

assistant: **Innovation**

There is a need for a ground-breaking technology to radically increase crop yields in Europe and beyond. Improved photosynthesis will be the foundation of these radical yield increases. We are an alliance of European plant breeding companies, a phenotyping technology developer and academic plant scientists. Our project aims to translate major advances in photosynthetic improvement from model plant species into three important crop species. We will capitalize on the three most promising strategies in model plants to identify the genetic resources needed to improve the photosynthetic properties of crop plants: (I) tuning of the Calvin cycle, (II) the kinetics of photosynthetic responses to changes in irradiance, and (III) tuning leaf chlorophyll content, thus providing new tools with which to increase the rate of CO2 fixation. To do so, we aim to discover the genetic basis for natural variation in traits associated with each strategy as well as use gene editing and transgenic engineering to improve photosynthesis in three major European crops: barley, tomato and maize. The findings will be used to build a complete roadmap including the feasibility of each specific technique to improve photosynthetic efficiency. Based on precedent, we expect that improving our targeted traits will result in increases in photosynthesis of 10% or more, and there will be added benefits in sustainability via better resource-use efficiency of water and nitrogen. A public dialogue programme will be used to ensure stakeholder engagement and explore further the societal limits to the acceptability of a range of technologies as potential routes to crop improvement. Looking to the 2030 horizon, this project will develop an adaptable strategy able to achieve 10% improvement in photosynthetic efficien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design and synthesis of high affinity carbohydrate ligands' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This aim of this research programme is to design, synthesise and characterise saccharides which are conformationally constrained around their glycosidic linkages and which correspond to good binding or recognition conformational isomers. This type of saccharides has not yet been reported and it is to be expected that they will bind with high affinity to carbohydrate-binding proteins. The work will involve (i) the preparation of compounds (1-4) which may be regarded as derivatives of the trisaccharide, BETA-D-GlcNacp-(1-2)-ALPHA-D-Manp-(1-3)-D-Man, and are conformationally restricted around the glycosidic linkages, (ii) the determination of the three-dimensional structures of the synthetic oligosaccharides by NMR spectroscopy and (iii) the determination of the thermodynamic and kinetic parameters associated with lectin-saccharide complex formation. The work will establish whether conformational constraints are important in the design of putative high affinity carbohydrate based drugs.