RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Two sides to every leaf: how and why plants control stomatal distribution between leaf surfaces?' in the context of a Horizon Europe call.

assistant: **Objectives**

Plant leaves are polar organs with different upper (adaxial) and lower (abaxial) surfaces. Stomata are adjustable pores in leaves that allow CO2 influx for photosynthesis and mediate water loss via transpiration. These key structures that control plant survival and productivity are polarly localised only in leaf abaxial epidermis in most plants (hypostomaty). Some plants have stomata also on the upper leaf side; such amphistomatous plants should have a fitness advantage due to a better photosynthetic capacity. How is the making of adaxial stomata regulated and why are they present in a minority of plants, given their potential fitness advantage, remains a major unanswered question.I aim to design hypostomatous variants of the amphistomatous model plant Arabidopsis to address the role of adaxial stomata in plant physiology and fitness to answer two key questions: 1) how and why are adaxial stomata made, 2) how stomatal distribution between leaf surfaces is determined. I aim to do this via pursuing 3 specific goals:1. Discover new regulators of adaxial stomatal development and evaluate the role of transcription factor SPEECHLESS in adaxial stomatal formation2. Understand the role of adaxial stomata in plant physiology and fitness3. Discover how stomatal distribution in leaves is set and regulated by environment and hormonesI will use a balanced suit of untargeted and targeted approaches to identify the roles of new and known genes in the regulation of adaxial stomatal development and stomatal distribution between leaf surfaces, and understand the costs and benefits of adaxial stomata under different environmental conditions. I hope to answer the fundamental questions, how and why adaxial stomata are made, and hence explain why most species are hypostomatous. I expect the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cognitive effects of cell lines from the h-2kb-tsa58 mouse hippocampal neuroepithelium grafted in rats with selective hippocampal cell fields damages' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content This project aims at characterizing the cognitive effects of conditionally-immortal pluripotent neuroepithelial cell lines, derived from transgenic mouse fetuses, and grafted in the rat hippocampus after ischaemic damage of CA1 pyramidal cells or colchicine-induced destruction of dentate gyrus granule cells. My contribution will include all surgeries (lesioning, grafting) and behavioural testings of rats for their learning abilities to find and remember the location of a hidden platform in the water-maze. Post-mortem histological and immunohistochemical assessments will also evaluate the lesion extents. survival, morphology and integration of the grafts in the hippocampal subfields of the host brain (CA1 / dentate gyrus) These experiments will provide cell lines readily available in-vitro and optimal for restoring cognitive function in rats given selective hippocampal subfields lesions. Training content (objective, benefit and expected impact) The Institute of Psychiatry is is a multidisciplinary centre, well-known in the field of neural transplantation. It possesses all research facilities required (technical competencies, equipments) and will allow me to learn and familarize with various innovative neuroscience techniques (see above) that may reveal extremely useful for my future research directed towards graftinduced cognitive recovery in brain damaged animals Links with industry / industrial relevance (22) The project integrates with other studies performed in the host institution and separately funded by national research grants and industrial support.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '100% electric high-power and intelligent propulsion system for new and used boat' in the context of a Horizon 2020 call.

assistant: **Objectives**

Small fast boats generate 10-15 times more CO2 than land vehicles over the same distance. In Norway, they produce about the same amount of CO2 as all domestic flights combined. Fossil-fuel boating also harms marine ecosystems and humans working in their vicinity. Abandoning fossil fuels bears obvious environmental and societal benefits. Furthermore, all electric boating can be a sound business choice over the boat lifetime, particularly during intensive use seen by professional boat users in aquaculture and ecotourism sectors. However, today’s boat users who wish to switch to all-electric propulsion face major performance issues. ICEs are more attractive in terms of speed and range, while the electrification of boats is highly cost- and time-intensive.  Evoy has developed a breakthrough patented electric propulsion system for boats in the 20-to-40-foot segment, E-G2. It delivers precisely what today’s boating market urgently requires in its quest for more environmentally friendly and technologically superior voyaging. Versus current market leaders, E-G2 offers up to 9.7-times higher system power and 6times higher charging power, maintaining 40-knots over 30 nautical miles and a full system charging in 15min - 1h. Our powerful accompanying software allows boat users to effortlessly digitise their boating data, monitor and adjust key operational parameters remotely and combine their data with key external information via the cloud.   Building on our proposed international piloting supervised by leading European boating companies such as AKVA Group, we expect to recoup all previous investment into E-G2 in the second year of commercialisation. We will reach an accumulated income of €88m with a 41x return on equity by 2026.  In this period, E-G2 will generate 69 new position
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SPIDIA for Personalized Medicine - Standardisation of generic Pre-analytical procedures for In-vitro DIAgnostics for Personalized Medicine' (SPIDIA4P), addressing dissemination and exploitation.

assistant: **Impact**

Molecular in vitro diagnostics and biomedical research have allowed great progress in personalised medicine but further progress is limited by insufficient guidelines for pre-analytical workflow steps (sample collection, preservation, storage, transport, processing etc.) as well as by insufficient quality assurance of diagnostic practice. This allows using compromised patients’ samples with post collection changes in cellular and extra-cellular biomolecules’ profiles thus often making diagnostic test results unreliable or even impossible. To tackle this, SPIDA4P aims to generate and implement a comprehensive portfolio of 22 pan-European pre-analytical CEN/Technical Specifications and ISO/International Standards, addressing the important pre-analytical workflows applied to personalized medicine. These will also applicable to biomarker discovery, development and validation as well as to biobanks. Corresponding External Quality Assurance (EQA) Schemes will be developed and implemented as well, aiming to survey the resulting quality of samples and diagnostic practice. SPIDIA4P will ensure stakeholder organisations involvements as well as training, education, and counselling as additional major foci of the project. The consortium will closely coordinate with large European public research consortia to obtain access to research and validation studies data serving as evidence for the new standards developments and achieved improvements of diagnosis, patient stratification and prognosis of disease outcome. At this crucial moment in the development of personalised medicine, SPIDIA4P proposes a coordination and support action that reunites 19 highly experienced partners in international standardisation for in vitro diagnostics, coming from private industry including SMEs, public
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Highly and Widely Effective, Water Stable, and Non Toxic Titanium-Phenolato-based Anticancer Chemotherapy'.

assistant: **Innovation**

Chemotherapy is the most common line of treatment for various cancer types, but it generally suffers from severe side effects. Cisplatin is a highly effective metallodrug employed in the clinic, limited by severe and irreversible nephro- and neurotoxicities and resistance development. Therefore, developing highly and widely effective chemotherapy that is non- or substantially less- toxic should impact immediately and significantly the welfare of society. The titanium metal is an attractive Pt alternative, as it is bio-friendly and non-toxic. Titanium dioxide, the final decomposition product of Ti complexes in water, is a safe material often found in food and cosmetics. Nevertheless, the rapid dissociation of past Ti complexes in water has hampered their development into drugs.Under an ERC-StG grant followed by an ERC-CoG grant, the PI has developed Ti(IV) complexes that are stable for weeks in water, with high in vitro activity toward numerous cells (also established on the NCI-60 panel of the NIH) and in vivo toward murine and human models with no clinical sights of toxicity in treated mice at effective doses, where mortality occurred in control animals treated with cisplatin at similar doses. Pharmaceutical entities have shown specific interest in taking the proposed compound 1 into clinical trials phase I. Some experiments are still required before an agreement can be made, as proposed herein. Through the parent ERC-CoG, mechanistic analyses are ongoing, but no animal studies are permitted. Thus, through the proposed study: (a) pharmacokinetic studies on compound 1 by ICP-MS will determine absorption, bio-distribution, and excretion; (b) In vivo studies of different models and with varying concentrations and formulation types will determine the therapeutic potential;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Geomicrobiology of Fe(II)-bearing Minerals and Nitrate-Reducing Iron-Oxidizing microbial cultures'.

assistant: **Concept**

Nitrate-Reducing Iron-Oxidizing (NRFeOx) microorganisms, which couple Fe(II) oxidation to nitrate reduction using organic matter or carbon dioxide as a carbon source, play an essential role on a global scale in three of the most important biogeochemical cycles: iron, carbon and nitrogen. From an ecological point of view, NRFeOx microorganisms are key players in several processes such as the biological oxidation of Fe in anoxic and dark environments, the reduction of atmospheric carbon dioxide and the removal of nitrate from polluted groundwater aquifers.The aim of this project is to analyze the ability of NRFeOx communities to thrive using Fe(II)-bearing minerals as an energy source, the ecological consequences of the mineral transformation, and to explore the mechanism of microorganism-mineral interaction, which is crucial to fully understand their role in natural environments. First, culture techniques will be applied to identify Fe(II)- bearing minerals that can be oxidized by NRFeOx communities. Subsequently, Molecular Biology techniques will be applied to analyze the structure and distribution of NRFeOx communities when they grow using minerals as an energy source and to determine the main actors in the process. Finally, analytical microscopy techniques will be used to study, at the nanometer scale, the interaction between specific microorganisms with the mineral surface. For this purpose, state-of-the-art techniques such as Confocal Raman Microscopy, Scanning Electron Microscopy-Energy Dispersive X-Ray Spectroscopy and X-Ray Photoemission Electron Microscopy will be correlated with Fluorescence In Situ Hybridization and Fluorescence Microscopy.The data obtained in the MinOx project could not only be applied to biotechnological processes and integrated into predict
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Direct versus indirect ultraviolet light-induced DNA damage in the genesis of human melanoma and non-melanoma skin cancer.'.

assistant: **Concept**

Primary Objective To provide new scientific information, of use to the Commission, concerning the relative importance of different wavelengths of ultraviolet (UV) light in the induction of the three major forms of human skin cancer. Key Subsidiary Objectives (i) To determine the role of indirect DNA damage (e.g. that caused by reactive oxygen radicals) in skin carcinogenesis, (ii) to develop a sensitive molecular screening method suitable for monitoring the accumulation of cancer-related mutations induced by UV in normal human skin, (iii) to use newly discovered human skin cancer markers, in particular the CDKN2A (p16) suppressor gene and the cell immortality enzyme telomerase, to improve understanding of the relative contribution of UV-A and UV-B effects in the induction of malignant melanoma.Experimental Approaches  In order to achieve the set goals the project work will involve the use of a wide variety of state-of-the-art  molecular biological methods, including the polymerase chain reaction (PCR), cancer gene cloning and  sequencing, and the highly sensitive (PCR-based) 'TRAP' assay (for measuring functional telomerase in skin  tumours). In addition, animal models (i.e. hairless mice) will be employed to construct detailed action spectra  for UV skin carcinogenesis. A new generation of assays for measuring UV-induced mutations in the p53  tumour suppressor gene in intact human skin will be developed.  Expected Achievements  Studies with hairless mice will provide a detailed description of the wavelength dependency of UV  carcinogenesis, particularly with regard to UV-A and UV-B contributions, and of the induced mutational  spectrum in UV-induced tumours. The degree of involvement of oxidative damage will have been determined.  A new generation of highly sensitive P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Jacob Blaustein Institutes for Desert Research Ben-Gurion University of the Negev Drylands Research Specific Support Action - SSA' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The Dryland Research SSA will support visits of European scientists to the Jacob Blaustein Institutes for Desert Research (BIDR) to conduct research on drylands-related issues under the Transnational Access Program. Located in the heart of the Negev dryland of Israel, BIDR offers a rare combination of an easily accessible dryland environment with all the logistics required for conducting modern multidisciplinary research. An integral part of Ben-Gurion University of the Negev, BIDR is composed of 6 research departments: Man in the Desert, Desert Ecology, Water Research, Solar Energy & Environmental Physics, Dryland Agriculture, and Dryland Biotechnologies.The mission of BIDR is to study and disseminate knowledge of the desert environment, based on basic and applied research, in order to:(1) explore potentials for utilizing national, regional and global drylands;(2) develop means to combat desertification;(3) develop means for sustainable development of populated drylands.The unique merit of BIDR, Multidisciplinary approach to drylands research, is the reason for proposing the entire BIDR as an SSA program. BIDR has 8 regional research stations and farms in the Negev dryland. These offer a wide range of climatic and landscape characteristics (rocky, sandy and loessial watersheds); altitudes 100-900 m above sea level); mean annual rainfall (20-300 mm); dryland types (hyper-arid, arid, semi-arid); biota (African, Asian, Mediterranean); farming type (intensive dryland agricultural farms as well as extensive agriculture and pasturalism); and other land uses (water resource development projects, nature reserves and ecotourism).All institutional facilities and field sites will be available to SSA guests. The infrastructure caters to visiting scientists, postdoctoral fellows an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polygermane Block Copolymers: Synthesis, Self-Assembly, and Applications in Nanotechnology' (PARIM), addressing dissemination and exploitation.

assistant: **Impact**

Polygermanes, polymers with a -GeR2- repeat unit, are a potentially useful class of inorganic polymers with exciting chemical, physical, and electronic properties.  Although recognized for having much promise, the study of polygermanes has been severely hindered by inadequate synthetic routes.In this proposal we target the creation of novel organogermanes as precursors for use in living anionic polymerizations.   The realization of living polygermanes will allow for their incorporation into block copolymers such that self-assembled germanium containing nanostructures can ultimately be achieved.    Potential nanotechnological applications are envisioned in nanolithography, photonics, and nanoelectronics.The applicant’s experience in synthetic germanium chemistry, combined with the host’s expertise in polymer and materials science, will be key to the proposal’s success.  The project is both interdisciplinary and multidisciplinary and includes aspects of organometallic chemistry, polymer chemistry, materials science, and nanotechnology.  The project will utilize the host’s existing international collaborations and will also establish new partnerships.   The proposal will significantly enhance Europe’s position in the fields of nanotechnology and materials science, an important goal of the FP7.  At the end of the fellowship the applicant aims to return to his home country to take up an academic position at a top university.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Untangling the impacts of technological transformations, globalisation and demographic change to foster shared prosperity in Europe' to be submitted under Horizon 2020.

assistant: **Abstract**

Technological transformations, globalisation and demographic changes are the three key mega-trends posing socio-economic challenges and opportunities for the EU. UNTANGLED aims to fill knowledge gaps about these trends by pursuing three main goals: (1) to provide detailed analyses at the macro-, regional-, sectoral-, and micro-level concerning the effects of these trends on labour market outcomes and inequality, and their winners and losers; (2) to develop comprehensive, model-based scenarios of the impacts of these trends in the next decades, overall and for various subpopulations, sectors and regions; (3) to develop policy recommendations fostering shared prosperity. UNTANGLED contributes to the work programme’s goal of promoting inclusive and evidence-based policy and informed public debates. In measuring effects, we disentangle the joint impacts of the trends on the changing demand of skills, employability, wage and income inequality, and mobility and migration patterns. We pay attention to effects by gender, age, skill level, and firm type. We use an interdisciplinary approach that combines quantitative and qualitative methods and adopts a cross-country perspective, covering the entire EU and accounting for developments in other continents. This helps to project the impact of shocks on global value chains. Our scenarios are firmly based on analytical results and created with two complementary models to provide robust results at the country-, sector- and regional-level. To develop assumptions and ensure relevance of scenarios, we engage in extensive consultations and set up feedback loops with stakeholders, which complement and validate the economic and institutional analyses. These stakeholder consultations help to develop concrete policy proposals aimed at shared