RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metal-Organic Hydrogels for Efficient Drug Delivery (MOHEDD)' (MOHEDD).

assistant: **Concept**

The treatment of glioblastoma – the most common, aggressive and lethal type of brain cancer with survival rated below 14% – requires novel and improved drug delivery systems to overcome the drawback of state-of-the-art local chemotherapy by using Gliadel wafers. MOHEDD aims to evaluate the feasibility of advanced nanoMOFs and hydrogel hybrids for controlled drug delivery into the commercial stage, with the idea of accelerating their access to the market as highly efficient delivery vehicles for glioblastoma. The novelty of MOHEDD’s technology lies on the synergistic potential of integrating nanoMOF particles, loaded with cancer drugs, within a hydrogel network to create a biocompatible, processible, tailorable system for efficient controlled drug delivery in glioblastoma. We use 3D sponge-like networks of hydrogels to promote the dispersibility of MOFs in their matrices, using the MOFs as high capacity drug vehicles as well as to tune the properties of the hydrogels. Through validation of drug loading and release with MOF@hydrogels, we will evaluate such composites for human (rat) glioma models. We expect to achieve pharmaceutical, clinical, academic and public impact throughout MOHEDD project by a close collaboration of industrial partners and clinical advisers. The industrial consortium stems from a successful spin-out of the academic group (Immaterial Labs), chemical manufacturers (BASF) and pharma companies (AstraZeneca) as well as clinicians. The success of MOHEDD will result in the translation of MOF@hydrogel systems to pharma industry through collaboration with Immaterial Labs.


**Keywords:** Metal-organic frameworks, Adsorption Technologies, Drug Delivery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The build-up and fate of self-gravitating systems in the Universe'.

assistant: **Concept**

The unprecedented amount of photometric, spectroscopic, and astrometric data for billion stars provided by ongoing and future surveys and instruments (Gaia, APOGEE, WEAVE, MOONS, 4MOST, LSST, ELT, JWST) are allowing and will allow the detailed exploration of the Galactic history. These data will include kinematic and chemical information for stellar populations in all Galactic structures, such as the Galactic centre, globular clusters (GCs), their streams and escapees. Therefore, it is extremely timely to build a large library of models to exploit the data using star clusters as fossil records of past satellite accretion events. This motivates my work at GEPI, where I will link the large-scale dynamical evolution of Milky Way-like disc galaxies to that of their pc-scale elementary bricks as globular and nuclear star clusters (NSCs). By means of detailed N-body simulations, I will model the merger history of the Galaxy and follow the evolution of the GC system formed in the Milky Way and accreted from satellite galaxies. I will also make significant steps in advancing the understanding of NSCs, their formation and evolution and their link to the evolution of GCs and bulge/disc stellar populations. This project will greatly benefit from the knowledge and research done in the ""Equipe Physique Stellaire et Galactique” of the GEPI laboratory at the Paris Observatory. This group has leading experts in the field of Galactic dynamics and stellar populations, chemical abundances of individual GCs, and is also strongly involved in the Gaia mission, and follow-up surveys (WEAVE, MOONS). Therefore, this environment is ideally suited for me to conduct my research. At the same time, I will bring in my expertise on the dynamical evolution of dense stellar systems, along with my inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Shaping a Preferable Future: Children Reading, Thinking and Talking about Alternative Communities and Times' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite overall agreement that children’s voices matter in the development of policies affecting them, little effort has beenmade to develop cultural practices encouraging utopianism as a critical attitude to reality and a means of facilitating theexpression of formative opinions on the part of children. Nor have young readers’ interpretations of utopian literature beeninvestigated as indicating their perception of the sociopolitical arrangements around them, including the context of the EU.Notwithstanding the popularity of YA dystopian fiction, little attention has been given to utopian contents in other children’stexts. A specialist in children’s literature studies and utopian studies, Deszcz-Tryhubczak addresses these lacunae in aproject examining utopianism as a significant element of discourse about children, manifesting in various cultural productsaddressed to them. She also conducts empirical participatory research (with children as peer researchers) aimed at creatingegalitarian spaces within which young readers are not only heard but also collaborate with adults towards a betterunderstanding of how books shape ideas for the desirable future. This approach—an innovation in children’s literaturestudies—has a huge potential for making children’s literature scholarship relevant to young people’s lives as a culturalpractice sustaining intergenerational dialogue. Thus this project is challenge-based and integrates unprecedentedlychildren’s literature studies, empirical studies of literature and media, utopian studies, and childhood studies. The fellow willpublish its results in one article and a co-edited a collection. She will organize a colloquium for international scholars. Herstay at Anglia Ruskin will be crucial in her obtaining full professorship and in her lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Van der Waals materials for integrated nanophotonics' (VALERIA).

assistant: **Innovation**

Integrated quantum photonics is pivotal for the implementation of quantum technologies and their transition from a laboratory to a real-life context. The building blocks of a photonic circuit may comprise one or more single photon emitters (SPEs) and diverse components, such as waveguides, beam splitters, interferometers etc. required for steering and processing the quantum signals produced by the sources. In order to minimise the circuit size and energy consumption, photonic circuits should integrate as many components as possible on a same chip. Currently, it is extremely challenging finding a single material that can be used both as SPE and medium in which the single photons are transmitted. The long-term vision of VALERIA is the achievement of a single-material platform for the realisation of on-chip photonic quantum devices exploiting the nanostructurisation of van der Waals crystals. Our final goal will be the fabrication of a device made of a single non-centrosymmetric transition metal dichalcogenide bulk crystal embedding site-controlled SPEs deterministically integrated with photonic crystal cavities and coupled to electric-field configurable waveguides/beamsplitters.


**Keywords:** two-dimensional materials, single photon emitters, photonic circuits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Health Monitoring and Life-Long Capability Management for SELf-SUStaining Manufacturing Systems' (SELSUS).

assistant: **Innovation**

The vision of SelSus is to create a new paradigm for highly effective, self-healing production resources and systems to maximise their performance over longer life times through highly targeted and timely repair, renovation and up-grading. These next generation machines, fixtures and tools will embed extended sensory capabilities and smart materials combined with advanced ICT for self-diagnosis enabling them to become self-aware and supporting self-healing production systems. Distributed diagnostic and predictive repair and renovation models will be embedded into smart devices to early prognosis failure modes and component degradations. Self-aware devices will built on synergetic relationship with their human operators and maintenance personnel through continuous pro-active communication to achieve real self-healing systems. This will drastically improve the resilience and long term sustainability of highly complex manufacturing facilities to foreseen and unforeseen disturbances and deteriorations thereby minimising energy and resource consumption and waste.The SelSus vision will be achieved by the development of a new synergetic diagnostic and prognosis environment which is fully aware of the condition and history of all the machine components within a system or factory and is in constant knowledge enriched dialogue with their human personnel. The SelSus project will adopt a systematic approach, supported by a well-defined work plan. The work plan comprises nine carefully defined work packages. In order to guarantee fully committed teams towards comprising goals, the number of individual work packages is kept clearly constrained. The strong industrial pull for the project will be translated into a clear set of industrial requirements aimed at well-defined demonstration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Patented small molecule therapeutics that target cancer stem cells for the treatment of glioblastoma and other brain cancers' (Curtana), addressing dissemination and exploitation.

assistant: **Impact**

Over 45,000 people die each year in Europe – and 255,000 worldwide – from cancers of the brain and central nervous system. Gliomas are the biggest killer, accounting for a third of all diagnoses and 80% of primary malignant brain tumours. Among these glioblastoma is the most common, most aggressive and deadliest. Standard of care treatment offers little hope for patients diagnosed with gliomas: there is no cure, the median survival is 14.6 months and the 2-year survival rate is 13.5%. Conventional therapies can reduce tumour bulk, but they are ineffective at killing the cancer stem cells that drive tumour progression. Curtana may have found the answer. Its novel approach targets a transcription factor, Olig2, which is instrumental in tumorigenesis, tumour expansion and survival. By inhibiting Olig2, Curtana’s small molecule compound, CT-179, kills cancer stem cells. Pre-clinical results show CT-179 to be cytotoxic in selected tumours, a potent radiosensitiser, orally bioavailable and well tolerated; it also crosses the blood-brain barrier and has a high therapeutic index relative to conventional cancer drugs. Most importantly, it increases survival rates (in early studies, median improvement was 68%). Results indicate it may have benefit for other cancers too – any in which Olig2 is highly expressed, including all gliomas and other cancers such as lung, ovarian and endometrial. The Phase 1 project will address the feasibility of carrying out the further pre-clinical and clinical studies required before Curtana can apply for drug marketing approval. This will include identification of clinical partners for multi-centre trials that would be carried out in Europe in Phase 2, as well as potential investors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An Intelligent Platform for Personalized Remote Monitoring of the Cardiac Patients with Electronic Implant Devices' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Over the last decade, there has been an exponential growth in the number of cardiac implantable devices, in their electronic and software complexity widening their function and application. However, due to their limited processing capabilities restricted by their size, CIEDs need to be supported with software running on the data centers. Currently, the data center processing is standalone with their custom software and proprietary interfaces. iCARDEA will expose CIED data through standard interfaces to develop an intelligent platform to semi-automate the follow-up of CIED patients with context-aware, adaptable computer interpretable clinical guideline models. The computer interpretable guideline models to be developed will be designed from re-usable building blocks to facilitate personalization of the patient care and follow-up workflow. The CIED data will be exposed through standard interfaces based on the HL7, ISO/IEEE 11073 standards and the IHE IDCO Profile. EHR interoperability will be achieved by exposing legacy EHR systems through standard HL7 CDA interfaces so that information about patients' medical history such as the non-cardiac conditions denoting contraindications to the proposed therapies can be obtained from the patient EHR data and used in the clinical follow-up workflow. The clinical guidelines will automate the risk assessment and hence support medical professionals by automatically assessing the situations and generating alarms. iCARDEA will introduce outcome indicators with the related steps of the clinical guidelines to measure the success of the care process so that it can be combined with expert feedback to achieve a closed-loop system. The patients will be empowered with Personal Health Records (PHR) to enable informed and responsible participati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High Performance and Large-Scale Electrodes for Selective Ion Recovery' in the context of a Horizon Europe call.

assistant: **Objectives**

The growing global concern surrounding water scarcity spurs societal impact by ensuring accessible and affordable freshwater resources. Furthermore, the increasing demand for high-value, non-renewable resources like phosphate and lithium, often found in waster or process water streams, coupled with their dwindling availability, requires robust strategies to establish secure supply chains.Electrochemical deionization (ECD) stands out as a promising solution due to its ability to fine-tune selectivity for specific ions. Over the past two decades, ECD has made remarkable progress, driven by factors like membrane use, surface functionalization, innovative cell designs, diverse electrochemical modes, and a deeper grasp of theory and application. Novel electrode materials, particularly intercalation materials, as developed and studied in the ERC Consolidator project E-Motion, have enhanced ion-selectivity in ECD.In PassIon the up-scaling and electrode stability that follow from our scientific results obtained so far  and our filed patent  will be validated. This will not only boost the desalination performance of ECD processes at larger scale, but also enable employment of such processes for resource recovery in an effective and sustainable way. Two work packages have been defined, one on the technical aspects and one on commercial activities. The team will regularly meet with the strategic advisory board to be installed and engage with potential end-users and sponsors, mainly via the vast networks of Wetsus and our industrial mentor.A risk analysis has been made and risk-mitigation measures are in place to boost the breakthrough innovation of combing desalination with salt recovery. PassIon is set to achieve Technology Readiness Levels (TRLs) 4 to 5 through validation, culmi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Liquid crystals based photonic devices' (1994-1998).

assistant: **Innovation**

LC PHOTONET NETWORK OVERVIEW Liquid crystals have good optical properties (transparency, homogeneity, birefringence, etc.). They can be easily included in microdevices and fibres, and are low cost components. Moreover, they can be mixed with other substances in order to obtain new composite materials having completely different and very interesting optical, electro-optical, thermal and mechanical properties. Finally, they are sensitive to external fields, including optical fields, so they can be used as active materials in optical and electro-optical devices. The main limitations of liquid crystals in their use for optical and electro-optical devices are their response time and optical quality. Response time is an intrinsic limitation of liquid crystalline materials, so that, at present, it seems impossible to make electro-optical devices having an overall response time less than few microseconds. It should be stressed, however, that for a great number of practical applications e-o devices with time responses less than 1 ms are considered fast. In these cases, the use of liquid crystals may present great advantages, provided the problem of optical quality is seriously addressed. It is thought that high grade LC optical devices can be developed if appropriate technologies are adopted. Besides TV LC displays, a number of optical and electro-optical LC devices are already commercialised, particularly by SMEs outside the EU. The market is growing rapidly, but at the same time end users are stepping up requested features and performances of phototonic devices. Moreover, new LC composites and new optical and electro-optical effects based on these materials have been discovered and studied in the last years which are likely to have a significant impact in the industrial sector
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigation on ceramic tools for carpect manufacturing' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

At present only metal tools are being used in the tufting industry. Ceramic tools have proved their resistance to wear in other areas of the textile industry. A hurdle which has prevented them from being used as cutting tools in the past was the unfavourable brittle fracture behaviour. By using an advanced production technology and specially composed components, it is possible to design materials with a high degree of hardness and improved fracture toughness. Compared to cemented carbide and steel the resistance against abrasion and chemical wear at the cutting edge shows further advantages. If the abrasion behaviour of the materials mentioned-steel, hard alloy and ceramics is looked upon concerning a highly abrasive yam it shows that the ceramics is by far the smallest. To take advantage of this for a tufting tool, it is necessary to pay attention to special instructions referring to the design of Ceramic tools. The use of Ceramic tips for this application is new. The design differs widely of the one in other application fields. It is especially important that the application conditions which are present are representative and typical for the textile industry so that the basis for further application possibilities will be created.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Elasticity and unfolding studies of single molecules of the cytoskeletal protein spectrin' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Mechanical properties of the skeletal protein spectrin will be investigated by .scanning probe techniques: atomic force microscopy and optical tweezer.s. We plan to determine experimentally the force-extension relationship and so the visco-elastic properties of a single molecule of spectrin. At some threshold, a stress-relaxation behaviour is expected and shall be studied. Furthermore, the study shall reveal the unfolding of separated domains of spectrin. Genetically modified spectrin will help to understand the relation between mechanical properties and structure. Training content (objective, benefit and expected impact) This research will provide me with a training in the techniques of molecular biology and will thus develop the necessary skills to work as a physici.st at the Physics/Biology interface. The experience that I have acquired on fine optical and mechanical techniques will help the realisation of this experimental study on a fundamental mechanism of Life. Links with industry / industrial relevance (22)