RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Shared anchors for floating wind turbines', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

On the framework of the energy transition in Europe, new technologies are under research, development and implementation. One of the targets of the European Commission is by 2030 to achieve a 32% of energy capacity based on renewable sources . Offshore wind energy is one of the renewable energy sources contemplated in the European Strategic Energy Technology Plan (SET Plan) as part of the actions for research and innovation. New potential areas with more intense and stable wind conditions and minimized visual impact on the coastline have been identified  (deep waters of >60 m depth). This motivates the idea of implementing floating wind turbines as an alternative to reach deep water locations with a great potential as a step further in the offshore wind industry. One of the main challenges for this technology is the cost associated with the construction of the platforms for the wind turbines and the mooring systems to anchor the turbines in deep water. One of the solutions to optimize  offshore floating wind farms costs is sharing the anchors connected to the mooring systems that secure the wind turbines when subjected to the ocean environmental laods.  The research proposed here ""Shared anchors for floating wind turbines- ShareWind"", aims to provide design guidelines and evaluate the loading capacity of shared anchors installed in clayey seabed profiles as most of the research on this topic has been adressed in sands. As part of ShareWind, the applicant will (i) develop physical models of shared anchors to be tested at theUniv.Eiffel (France)  geotechnical centrifuge, (ii) perform numerical simulations and parametric studies to provide design guidelines and failure envelopes of anchors subjected to multidirectional cyclic loading. The results of ShareWind will be int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'OMT - Optomechanical Technologies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proposed project is built on the successful training and research experience of the leading European research groupsworking in the field of cavity optomechanics. Our ENT unites a total of 14 leading groups in the field, of which two are major industrial players that utilize MEMS and NEMS - Bosch and IBM.  The main goal of the project is to exploit optomechanical interactions in views of novel functionality and possible applications of cavity optomechanical systems that were envisioned by consortium partners during their previous research activities. The possible applications include for instance MEMS sensors based on two-dimensional materials like graphene, quantum limited microwave amplifiers, and low noise optical to microwave frequency photon converters. While the majority of the experiments will firmly reside in the realm of classical, albeit weak, signals or fields, the aspired performance will also allow exploiting schemes in scenarios where quantum nature of the signal is relevant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Forum for researchers and regulators to meet manufacturers of toxicology test methods' (FORINVITOX), addressing dissemination and exploitation.

assistant: **Impact**

Research on in vitro replacement tests has been undertaken by researchers and industry in the past years with the support of the European Commission, which has resulted in an important number of scientifically sound methods and new strategies. However, the transfer of these inventions to potential users has been much slower than expected, mainly due to difficulties encountered in the transferability, official approval as well as production of test kits under conditions that meet good laboratory practice (GLP) requirements. In order to ensure that results from EC funded projects reach the desired impact, the present gap between inventions and potential users needs to be bridged. The purpose of this project is to establish a forum where representatives of manufacturers, research projects and regulatory agencies continuously get a chance to discuss how to speed up the process of making in vitro methods available for end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular evolution of protease substrates involved in carcinogenesis by in vivo selection of retroviral display libraries' (1998-2002).

assistant: **Innovation**

The transition from benign to malignant phenotype involves the protease-mediated breakdown of basement membrane surrounding a primary cancer, allowing cells to escape and initiate metastatic tumours. The complex proteolytic machinery responsible for this process is supplied and regulated by the invading cells and the stromal cells. This proposal describes highly innovative strategies based on molecular evolution of retrovirus peptide display libraries to determine the substrate specificities of these proteases under physiological conditions, to generate programmable retroviral targeting vectors selective for sites of tumour invasion and to clone novel tumour associated proteases. The project will facilitate the improvement of molecular evolution technologies, the understanding of tumour invasion and the development of anti-cancer therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Probing the evolution of promiscuity and functional diversification among ancient gene duplicates' (FuncEvoDupliGenes), addressing dissemination and exploitation.

assistant: **Impact**

Gene duplication followed by sequence divergence is recognized as a key mechanism in evolution to generate functional innovations and enrich the complexity of genetic networks. Though gene duplication is frequently observed, the ensuing process leading to functional differentiation among gene duplicates remains obscure. Lack of this critical information has limited not just our fundamental understanding of protein evolution, but the success in engineering enzymes for industrial applications and our ability to predict evolution, for instance, mutations accessible to pathogens against antibiotic treatments. To fill this knowledge gap, I propose an integrative approach to bring mechanistic insights into the functional diversification among flavoprotein disulfide reductases (FDRs), namely glutathione reductases, lipoamide reductases, soluble transhydrogenases, and mercuric reductases. Diverged before the split between prokaryotes and eukaryotes, these ancient gene duplicates now participate in distinct branches of cell metabolism but maintain remarkable sequence and structure conservation. Furthermore, they exhibit the ability to turn over secondary substrates (i.e. promiscuity). I will address the evolutionary history, functional divergence, and mechanistic basis of promiscuity of FDRs, and explore their utility for biotechnology through the following steps: (1) phylogenetic reconstruction of ancestral FDRs to examine the functional shift from ancestral to extant FDRs, (3) directed evolution of one or more FDRs toward novel functions, (4) replaying gene duplication and functional divergence of FDRs in real-time by microbial evolution experiments. This project is aimed at answering core questions in molecular evolution and exploring the utility of promiscuous enzymes by bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mathematical Modelling and Optimization of Programmable 5G Networks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The exponential  increase in mobile data traffic warrants disruptive changes in the design and management of cellular networks. The next generation (5G) networks target to support a variety of applications having diverse requirements in data rates, latency, energy, etc. To address this surge in traffic demand and the associated heterogeneity in service requirements, several candidate technologies are being investigated under the 5G vision, naming a few: 1) Ultra-dense network deployment for high spatial capacity; 2) Network slicing to support heterogeneous service requirements; and  3) Cloud radio access networks (CRAN), etc. An  important element of the 5G vision is to achieve a 50% reduction in the total network energy consumption. To ensure that the future networks meet  both the service and the sustainability requirements, energy-efficient designs and integration of renewable-energy sources into the network infrastructure are needed.  To address the sudden capacity demands, on-demand network deployment is desired, instead of maintaining a permanently over-engineered infrastructure.  Inclusion of  these approaches result in highly complex and stochastic network topologies. Modeling and optimizing such networks is a challenging problem.  State-of-the-art approaches are not adequate to model these new scenarios, and different mathematical techniques are required. This proposal addresses the optimization and modelling challenges pertaining to the  energy efficiency and service requirements of  the future ultra-dense networks by: 1) The development of novel energy-efficiency models to ensure energy–neutral network operation considering renewable energy sources; 2)  Innovative modeling framework for self-organized drone-assisted network infrastructure; 3) A unified progra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protein signalling pathways elucidated via novel correlation analysis of molecular dynamics simulations' under Seventh Framework.

assistant: **Concept**

Signal transduction enables biological cells to respond to external stimuli such as light, odours, hormones, or growth factors. Signalling is involved in numerous biological processes and dysfunction of signalling has been associated to severe conditions such as cancer or Alzheimer’s disease. Whereas the knowledge of signal transduction on the cellular level has seen impressive progress within the last years, the molecular mechanisms involved in signalling remain mostly unknown. Intra-protein signalling is accomplished by subtle configurational changes and/or rapid dynamic processes which are difficult to assess experimentally. Therefore, we aim to employ molecular dynamics (MD) simulations to elucidate intra-protein signalling pathways and molecular mechanisms involved in signalling. Two important classes of signalling proteins will be studied: G-protein coupled receptors (GPCRs) and PDZ protein binding domains. The key to elucidate the signalling pathways will be to identify the correlations in protein dynamics and ensembles which transmit the biological signal. We plan to employ procedures from information theory and multivariate analysis to directly assess the propagation of the signal in the protein motions. The approach promises to clearly separate intra-protein processes involved in signalling from motions and interactions which may be important (e.g. for protein stability), but which do not contribute to the signal. Moreover, the simulations will allow us to distinguish between the “induced-fit” and the “conformational selection” model for signal transduction. By applying these methods to GPCRs and different PDZ domains we aim to determine common routes of information transfer within these important classes of proteins. Understanding how information is transferr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Signals from the Surface Snow: Post-Depositional Processes Controlling the Ice Core Isotopic Fingerprint'.

assistant: **Objectives**

For the past 50 years, our use of ice core records as climate archives has relied on the fundamental assumption that the isotopic composition of precipitation deposited on the ice sheet surface determines the ice core water isotopic composition. Since the isotopic composition in precipitation is assumed to be governed by the state of the climate this has made ice core isotope records one of the most important proxies for reconstructing the past climate.New simultaneous measurements of snow and water vapor isotopes have shown that the surface snow exchanges with the atmospheric water vapor isotope signal, altering the deposited precipitation isotope signal. This severely questions the standard paradigm for interpreting the ice core proxy record and gives rise to the hypothesis that the isotope record from an ice core is determined by a combination of the atmospheric water vapor isotope signal and the precipitation isotope signal. The SNOWISO project will verify this new hypothesis by combining laboratory and field experiments with in-situ observations of snow and water vapor isotopes in Greenland and Antarctica. This will enable me to quantify and parameterize the snow-air isotope exchange and post-depositional processes. I will implement these results into an isotope-enabled Regional Climate Model with a snowpack module and benchmarked against in-situ observations. Using the coupled snow-atmosphere isotope model I will establish the isotopic shift due to post-depositional processes under different climate conditions. This will facilitate the use of the full suite of water isotopes to infer past changes in the climate system, specifically changes in ocean sea surface temperature and relative humidity.By establishing how the water isotope signal is recorded in the snow, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'LIACFLASH: a life changing IOeRT technology for oncology care' in the context of a Horizon Europe call.

assistant: **Objectives**

Radiation Therapy is, along with surgery, the most effective therapeutic approach for the treatment of solid tumours. Unfortunately, biological effects of radiation dose to healthy organs at risk (often surrounding targeted tumour mass) represent a major dose-limiting constraint in Radiation Therapy. This implies that tumours cannot be always successfully treated, as delivered dose might not be enough for an effective treatment, decreasing survival of these cancer patients. LIACFLASH is an IOeRT system for cancer treatment built on a breakthrough scientific discovery: the FLASH effect, which enables delivery of high radiation dose with significantly reduced associated radiocytotoxicity, while achieving efficient tumour killing, widening the therapeutic window.


**Keywords:** Flash Radiotherapy,radiocitotoxicity,therapeutic window,Solid tumours,Surgery,IOeRT,Cancer treatment,medical linear accelerator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European analysis on standardisation of measurements of low back disorders' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Brief Description:Low back disorders (LBD) are one of the major health problems in Europe. The multidimensional outcome of LBD concerns signs, symptoms and functions. A consensus on a valid standard measurement, which is the state of the art in respiratory and cardiovascular diseases does not exist for the classification of LBD. The measurements differ in respect to professional, personal and local preferences. As a consequence, risk characterisations or recommendations for a specific prevention at the workplace suffer from lack of comparison. However, the repeatability of specific measurements used in different countries and by different professions is accessible and will be analysed.The study comprises of three components. First, the listed relevant European studies on measurements of LBD will be reviewed in respect to measurements used and repeatability of the measurements. Second, additional repeatability studies of measurements applied in the listed studies will be selected and performed. Third, a consensus on a core instrument of LBD will be developed on the basis of the review, the additional analysis and discussions within the participants of the Concerted Action and external experts.The task of developing a harmonised standard measurement for LBD can only be achieved effectively in co-operation. Several sites within Europe have a strong holding in work-related musculoskeletal disorders. Relevant research groups from different European countries with access to previous and ongoing studies on LBD have agreed to contribute to the planned Concerted Action. Thus, the present situation provides a unique chance to agree on a core instrument for the measurement of LBD.The results of the standardization can be implemented immediately among the working population. On the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Ecehe'.

assistant: **Innovation**

Health care systems across Europe face the common problems of containing expenditure, while promoting efficiency and ensuring universal access. In response, there has been rapid development in the field of health economics. However, relatively few European researchers are at the frontiers of quantitative research in this area and there is a clear rationale for meetings at the European level to obtain a critical mass of participants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BRIDGing the research and INnovation Gap for Rare Diseases in Europe by upgrading excellence of IMGGE' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

There are over 330 million people living on the planet affected by one of over 6,000 identified genetic rare diseases (RD). They urgently need timely diagnosis and development of specific treatments. Although Europe leads the way in RD research, there is a clear gap in research and innovation (R&I) between countries. To bridge this gap, networking and knowledge sharing between IMGGE (Institute of Molecular Genetics and Genetic Engineering, Serbia) and 3 world-class counterparts at EU level - KI (Karolinska Institute, Sweden), CNAG (National Center for Genomic Analysis, Spain) and UAM (Autonomous University of Madrid, Spain) is envisioned. BRIDGING-RD’s  objectives are: (1) upgrade the IMGGE RD Biobank to reach full interoperability of genetic and phenotypic data in order to increase participation in transnational research and innovation projects related to human health; (2) upgrade bioinformatics pipelines specific to RD to increase the rate of solved RD cases in IMGGE’s RD Biobank; (3) upgrade capacity for modelling of metabolic diseases as well as capacity to test small molecule drugs, in order to increase the number of translational studies; (4) upgrade research support offices in order to increase success in obtaining funds from research and/or innovation agencies, industry, foundations etc. Objectives will be achieved through staff exchanges, expert visits, trainings or workshops, conference attendance, joint summer schools and dissemination/outreach activities. Crucially, an exploratory R&I project, engaging all partners will focus on identifying an innovative drug, pharmacochaperone, for a selected metabolic RD. BRIDGING-RD will have impact by significantly improving the scientific excellence and innovation capacity of IMGGE, raising its research reputation and r