RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design of MYB specific inhibitors' to be submitted under Seventh Framework.

assistant: **Abstract**

During my ERC starting grant project, my lab has identified small molecule inhibitors that inhibit the proliferation of MYB-dependent leukemia cell lines. In this proof of concept project, we aim to investigate the potential of these compounds to be further developed as anti-cancer agents. We will determine their potential to inhibit the proliferation breast cancer and colon cancer cell lines and possible additional activity against other solid tumors. In addition, we will investigate the IP landscape and possibilities to improve the chemical properties. These pre-clinical data should provide the basis for the further development of these MYB inhibitors as anti-cancer agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Function, Mechanism, and Regulation of Mammalian Mov10L1 RNA Helicase'.

assistant: **Concept**

Adult cardiac myocytes retain the ability to respond to a variety of stimuli by hypertrophic growth. Hypertrophy is initially beneficial, permitting enhanced cardiac output; it can ultimately become deleterious and result in cardiomyopathy, heart failure, and sudden death. Mitogenic signaling drives cell cycle progression as consequences of their effects on cyclins, which interact with cyclin-dependent kinases and cyclin-dependent kinase inhibitors. Recent work showed that CHAMP has antihypertrophic activity, which requires the conserved ATPase motif that is characteristic of RNA helicase superfamilies 1 and 2, and is associated with up-regulation of the cell cycle inhibitor p21CIP1 and p27KIP1. CHAMP is localized in the cytoplasm of cardiomyocytes and is likely regulates its target RNA at the level of translation and degradation.  The regulation p21CIP1 and p27KIP1 translation levels controls the proliferation of cardiomyocytes by inhibiting cell cycle progression.  However, very little is known regarding the molecular mechanism of how RNA helicases regulate translation. To date detailed enzymology regarding the mechanical transduction of RNA helicases is scarcely known, especially from superfamily 1 to which CHAMP is identified with. This proposal is aim to decipher the molecular mechanism of a putative RNA helicase CHAMP and how it regulates mRNA metabolism of genes essential for the heart development during prenatal stages and regulates CDKI’s mRNA in postnatal stages. The research program will integrate state of the art molecular biochemistry and biophysics approach with medicinal translational research. An interdisciplinary structured based team will be assembled to integrate knowledge, and capacity from molecular to physiological aspects of cardio myocytes hypert
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European workshop on probabilistic risk assessment for plant protection products'.

assistant: **Objectives**

EU Directive 91/414 requires Member States to analyse the impact on the environment of plant protection products. Current methods do not take full account of uncertainties affecting risk. This causes problems in decision-making. Probabilistic methods can help solve these problems, by quantifying uncertainty.This workshop will initiate work towards a harmonised European approach. Its tasks are to:1. Review the worldwide state of the art.2. Identify which aspects of evaluation under Directive 91/414 could be improved by using probabilistic methods.3. Define priorities for further research and implementation.About 100 participants will be invited, including international leaders in the relevant scientific fields. The workshop report will document the proceedings and provide practical recommendations on whether and how to implement probabilistic methods in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Covering mappings and their applications in functional equations, difference equations and optimization""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

There will be considered covering mappings and their applications. The properties of covering mappings in generalized metric spaces will be studied. Moreover, sufficient solvability conditions for inclusions defined by conditionally covering multi-valued mappings in metric spaces will be obtained. This results will be applied to the following problems. For difference equations there will be studied such issues as solvability,  equilibrium existence and stability. In addition, there will be studiedseveral types of functional equations. This part of research will be based on the result obtained for covering mappings in generalized metric spaces. Finally, there will be studied questions of global solvability for control systems and necessary optimality conditions for control systems defined by Volterra equations.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CoLD NEUTRON FACILITY AT DR3 THERMAL NEUTRON FACILITY AT NFL' under Fourth Framework.

assistant: **Concept**

The Studsvik Neutron Research Laboratory (NFL) proposes to make some of its facilities for neutron scattering and neutron physics-available-to scientists in the EU through the Large Scale Facilities program. This proposal is made jointly with the Risoe National Laboratory in Denmark who already run such a program very successfully. There is at present a considerable over-demand for access to neutron scattering facilities by European scientists; this program will help to reduce that demand. The instrumentation offered at NFL will be complementary to that at Risoe. Initially NFL will include in the program the liquids and amorphous diffractometer SLAD (also suitable for very rapid medium resolution powder diffraction), the depolarisation analysis instrument POLAR1 and the on-line radioactive isotope separator OSIRIS. High resolution powder, single crystal and residual stress diffractometers are also available if there is a high level of demand for similar instruments at Risoe. It is planned to increase the beam time offered at NFL. over a 4 year period, from 20 to 30 to 40 beam weeks/year as construction of new instruments is completed. These will include a thermal time-of-flight spectrometer. Within the program at NFL we want to build a close collaboration with materials scientists. We will offer flexible arrangements suited to those synthesising new materials (e.g. rapid testing of materials prior to allocation of beam time) and develop special methods for studying processes in situ. The program will be managed jointly with Risoe. with no significant changes to the arrangements already in existence. The mechanism for selection of experiments will remain the same.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Application and standardisation of biochemical fingerprint techniques in view of the risk assessment of toxicants in soil ecosystems'.

assistant: **Concept**

A main objective in environmental policy of the European Commission is the safeguarding of soil ecosystems against detrimental effects of chemical contaminants. Therefore, EC-funded research is aiming to develop specific ecotoxicological test methods using terrestrial invertebrates. The advantage of these tests over chemical analysis of toxicants is that they account for bioavailability of hazardous compounds or detrimental effects on organisms. Furthermore, combined effects of different toxicants or the presence of unknown compounds can be measured using these test methods. Biochemical fingerprint techniques offer perspectives as tools for the risk assessment of chemicals in soils. By using biochemical indicators (biomarkers), they have the potential to bridge the gap between chemical analyses and impairment of physiology leading to effects at the ecosystem level. At present, different biomarker test systems for soil organisms, which include heat shock proteins, metal binding proteins, esterases and specific metabolic patterns, are under development and preliminary results are promising. The biomarker response appears to be a sensitive early warning of chemical stress before sublethal effects, such as inhibition of growth or reproduction, become apparent. Combined effects are integrated in the biomarker response and also unknown compounds are accounted for. The main objective of this collaborative project is the deployment of biochemical fingerprint techniques, which have already been developed, for assessing the exposure and effect of toxicants on soil invertebrates in the field. The participants are connected by: 1) applying specific biochemical expertise from each participant to various invertebrate species, 2) assessing confounding factors of biomarker response, 3)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microwave driven ion trap quantum computing' (MicroQC) targeting Horizon 2020.

assistant: **Abstract**

The construction of a large-scale trapped-ion quantum information processor can be made decisively simpler by using the well-developed and compact microwave technology present already in today’s mobile phones and other devices. Microwave technology has tremendous simplification potential by condensing experimental effort from an optical table with several square meters of accurately aligned optical components down to an engineered conductor microstructure embedded into a chip surface and a few off-the-shelve microwave components. Thus, this technology can be the key enabling step for addressing the formidable challenge of a scalable quantum processor. Although the field is still in its infancy, there is rapid progress: a fidelity of over 99.9999% has been achieved for single-qubit gates and 99.7% for two-qubit gates. This technology allows execution of quantum gates by the application of a voltage to a microchip potentially replacing millions of laser beams and it can operate at room temperature or mild cooling. There are still enormous technical challenges in scaling ion trap (or any other) systems up to the millions of qubits required to implement meaningful full-sale quantum computation and simulation. The main objective of MicroQC is to demonstrate, through state-of-art quantum engineering, fast and fault-tolerant microwave two-qubit and multi-qubit gates and to design scalable technology components that apply these techniques in multi-qubit quantum processors. The successful accomplishment of these objectives, in a combined effort by five leading groups in this field – three experimental groups, including the pioneers in microwave quantum logic with static and oscillating magnetic gradients, and two leading theory groups – will make large-scale quantum computation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Efficiency control and performance verification of improved approaches for soil-groundwater protection and rehabilitation' under Sixth Framework.

assistant: **Concept**

The overall aim of PROMOTE is to set up an efficiency control and performance verification (ECV) system for soil-groundwater protection and rehabilitation based on a more generic testing and performance verification concept, in a network of testing centres. This is in direct accordance with the ETAP procedure. A strong impact of PROMOTE is to be expected concerning a faster market introduction of novel techniques hence strengthening the competitiveness of technology developers in Europe. This guaranteed by an extensive integration of SMEs and Eastern European partners. PROMOTE will gain the potential to act as a germ cell of a pre-normative verification system, overcoming implementation barriers and bridging the gap between innovative and standardised techniques. Main scientific-technical objectives are:-Assessment of existing verification tools and identification of demands on techniques to support the implementation of the WFD, the GWD and the evolving Soil Protection Strategy-Elaboration of a generic testing and performance verification concept designed to be basically applicable to abroad range of environmental technologies-ECV system development for remediation and monitoring approaches in soil-groundwater systems-ECV system verification on a reference and a field site-ECV system transfer to related environmental technologies-Establishing a ECV platform by including the CEN Workshop" tool beyond the projectThe ECV system set-up is divided in four phases:(1) Organisational phase,(2) Operational phase,(3)Assessment and verification phase and(4) ECV establishment and dissemination strategy, comprises a conceptual review and testing of the ECV applicability, the ECV general validity, comparison of ECV with other systems and stakeholder consultation. Phase (4) includes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Animating Metamaterials using Non-Reciprocity' to be submitted under Horizon Europe.

assistant: **Abstract**

Living materials such as cells, tissues and simple organisms are animate. They autonomously and adaptively navigate their environment and are resilient to damage. Can we take inspiration from Nature and create synthetic animate materials? This dream has now become tangible thanks to major progress in the field of mechanical metamaterials. Metamaterials are composites that exhibit exceptional properties by leveraging geometric effects within their architecture. For example, they exhibit on-demand shape-changes and guide waves unidirectionally. Such functionalities are extremely promising to achieve animacy: pairing unidirectional waves with shape-changes can power locomotion—a crucial aspect of animacy. Yet, the locomotion of such metamaterials remains poorly understood and we lack design principles for their design and control. Therefore, metamaterials cannot locomote in complex and unpredictable terrains.I propose to overcome these limitations by introducing a new class of shape-changing metamaterials that are non-reciprocal. I will add robotics to the metamaterials toolbox by using distributed sensors, actuators and feedback control to break mechanical reciprocity, viz. Newton’s third law. These non-reciprocal metamaterials are described by asymmetric matrices and tensors and display unidirectional patterns of shape-changes. I will harness these patterns to create three-dimensional metamaterials that can autonomously roll, crawl and jump, and that display optimal locomotion performances in complex and unpredictable terrains.Just as living materials have deeply integrated and distributed functions, metamaterials will achieve animacy by interweaving shape-changes and non-reciprocity. ANIMETA will blur the boundary between metamaterials and robotics, provide new insights
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Partitioning and transmutation' under Fifth Framework.

assistant: **Concept**

Specific Objectives- Within the research on aqueous partitioning techniques for the separation of long-lived actinides and fission products, to generate high active raffinates from dissolved spent fuel, and to produce from the raffinates high active concentrates, which will be used for separation of minor actinides in the DIAMEX process;- To demonstrate the electro-refining of actinides using U, Pu, Am, Cm, ZrRE alloys, and to perform tests of salt-metal extraction for the separation of minor actinides;- To prepare the transfer of the pyrochemistry caisson for shielding in the hot cells facility;- To finalise the commissioning and start the hot operation of the MA Lab for the manufacture of fuel pellets and pins for transmutation experiments;- To manufacture in the MA Lab Pu and Am containing fuels (zirconia-based, homogeneous and composite compounds) to be used for characterisation and for transmutation experiments;- To perform the new irradiation experiment SMART in HFR Petten (collaboration with IE), for the testing of high Pu-containing fuels (including inert matrices) in fast reactor systems;- To determine the material properties of zirconia-based targets and fuels;- To conclude the analysis of EFTTRA-T4 (spinel inert matrix);- To fabricate by the infiltration method Pu-containing pyrochlore pellets, and to measure their properties;- To assess advanced nuclear fuel cycle concepts with regard to waste generation (radio-toxicity), and material accountancy (non-proliferation);- To assess thermodynamic data (Pu, Am, Cm oxides) and include them in the new ITU data base.Planned Deliverables- Produce 7 litres of raffinates, and high active concentrates according to the aqueous reprocessing process;- Installation and testing of new centrifuges;- Installation of new equipme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation of the biotechnological interest of an H2-overproducing bacteria isolated from the deep subsurface', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The biotechnological production of hydrogen (H2) as a clean energy source faces distinct challenges and limitations. These include the need to balance the requirements and efficiency of metabolic reactions involved in H2 generation, improve the utilization of industrial waste byproducts as substrates, and address the relatively low level of commercialization. In consequence, there is an impending need to searching for and identifying microorganisms with new metabolic pathways capable to produce biohydrogen as a source of clean energy, as well as exploring alternative substrates such as the residues of different biotechnological processes.During the implementation of the ERC-CoG MARSFIRSTWATER, we have isolated from the deep subsurface a member of the bacterial genus Citrobacter (Citrobacter sp. T1.2D-1), and our preliminary research shows that it exhibits the potential of producing H2 from different substrates in strictly anoxic conditions. The ambition of DEEPENERGY is to provide the technical basis to develop and deliver an innovative methodology to use Citrobacter for the bioproduction of H2, avoiding the limitations of the existing procedures.We aim to proof our concept by completing the following objectives:1. Evaluation of the anticipated economic interest of Citrobacter sp. T1.2D-1 as a biotechnological H2 producer using glycerol as substrate, bringing this knowledge into a pre-commercial stage technology.2. Development of a hybridization probe to identify additional members of this genus along the IPB, which may also have economic interest.3. Filling patent(s) to protect the strain(s).The goal of DEEPENERGY is to introduce a transformative element in the energy-producing H2 biotechnology that addresses urgent industrial and environmental needs. DEEPENERGY aims t