RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Atalanta is TransnAtionaL Accelerator NeTworks Acceleration' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall objective is to drive innovation, facilitate technology transfer and to support entrepreneurship on a transnational European level to contribute to the exploitation of more innovative products and services coming from European 36R&D projects and to support the creation of more successful ICT start-ups in Europe. This overall objective will be achieved through actions and events organised in thematic domains as well as the use of existing electronic platforms and networking tools. The project will have a special focus on acceleration programmes, which are the new paradigm regarding entrepreneurship support. With the focus on accelerator programmes, the project will complement the activities of incubator networks like the EBN. Accelerator programmes are not seen as a competing concept to business incubation, but as a complementing measure with the objective to accelerate the incubation of the most promising enterprises.In more concrete terms, the project supports groups of leading accelerators for delivering cross border services to innovative SMEs and entrepreneurs and links these groups with knowledge creators and education organisations (i.e. mentors, trainers, service providers and partners) on one side and to investors (i.e. venture capital organisations) and the business world (i.e. potential clients, partners, suppliers and venture capitalists) on the other. This corresponds to the following detailed objectives:1)\tTransnational AcceleratorsInstall transnational cooperation networks of accelerators;2)\tLinking Knowledge Creation and Enterprise CreationInstall new transnational cooperation networks and improve existing networks by linking accelerators with innovation networks (e.g. EBN);3)\tCreating Synergy NetworksInstall new transnational synergy netwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dimensioning of error control mechanisms to optimise service quality and network resource utilisation in high-speed networks' (1994-1998).

assistant: **Innovation**

Research objectives and content The research project aims at the development and implementation of a support layer for communication middleware. A method will be developed and implemented for optimising protocol parameters of error control mechanisms in ATM networks to allow for an efficient use of network resources. At the same time, this project enables service providers to influence the adaptation of protocol parameters in order to optimise network utilisation, and therefore also service quality and revenues. The project thus will lower the cost of providing high performance communication services. The new method for optimising protocol parameters will be integrated into applications at the host institution, where a teleteaching application, a novel distributed Video-on-Demand (VOD) server, and an advanced application for Computer Supported Collaborative Work (CSCW) are deployed in the context of a 155 MBit/s ATM platform. The project will implement an innovative method for offering reliable services while achieving a high resource utilisation, and also an innovative method for billing of broadband services. Training content (objective, benefit and expected impact) The applicant will design a new method for protocol parameter optimisation, using custom libraries for analysis and simulation which were developed at the host institute. The applicant will be able to study protocol processing cost on specific end systems. He will also study the influence of protocol processing and of dynamic adaptation of protocol parameters by experimenting with advanced applications, which were developed at the host institute, and which run over a large ATM testbed. The applicant will develop a new method for billing and will analyse and extend an advanced tool for charging of broadband
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PLATform for Operation of distribution NEtworks'.

assistant: **Objectives**

To manage energy transition, DSOs require innovative tools. Volatile renewable energy sources in combination with less predictable consumption patterns call for higher levels of observability and exploitation of flexibility. While these two challenges are traditionally treated with separate means, PlatOne proposes an innovative approach to a joint data management for both. Fully respecting the existing regulatory framework, a layered set of platforms will allow to meet the needs of system operators, aggregators and end users. A blockchain based platform is the access layer to generators’ and customers’ flexibilities able to break traditional access barriers by providing certified measures to all the players. In conjunction, certified data and signals will be used for an innovative DSO platform to locally maintain system integrity fostering confidence in flexibility operations.  An upper layer will implement a new concept of blockchain-based open market platform to link the local system to the TSO domains and enhance the overall system cost efficiency. Because flexibility means customer involvement, PlatOne puts the grid users at the centre, investigates their needs and expectations and uses the underlying blockchain to unlock the potentials of higher dynamics of response. The platforms will be tested in 3 large pilots in Europe and analysed in cooperation with a large research initiative in Canada. Thanks to strategic partnerships and a unique consortium structure with an excellent network, PlatOne can offer an unprecedented effort of dissemination and exploitation with focus on DSO experts and final users.


**Keywords:** Data Platform, Flexibility Management, Blockchain, Energy Markets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Realising the technical and market potential for post-consumer plastics within the building and construction sector' (1994-1998).

assistant: **Innovation**

This proposal has been prepared with the help of an Exploratory Award, which included a Research Feasibility study. Clearly our finite natural resources are dwindling, but perhaps more importantly our ability to sustain landfill occupancy demand throughout the EU is severely restricted due to social, political, legislative and economic factors. The impetus to recycle post-consumer waste plastic is embodied within the European Commission Directive (94/62/EC), but how such material satisfies technical and market demands is unknown. The food and packaging sector is the number one market for plastic products, yet suffers from the demand for virgin material in contact with foodstuffs. The building and construction market is the second largest user of plastic materials, with life cycle utilisation orders of magnitude in excess of the food and packaging sector. Post consumer waste plastic constitutes a variable composition that must be quantified in terms of specification and suitability for end user markets. The aim of this project is to target, identify and establish new and improved methods for recycling and re-use of post-consumer waste plastics as materials for use in the building and construction industry. Risk is commensurate with the socio-economic, technical and market demands and has been well considered. It is justified by the significant potential direct benefits of waste minimisation, reduced raw material costs and new marketing opportunities. There are also indirect benefits in terms of environmental impact (reduced need for landfill), reductions in the use of non-sustainable raw materials and social impact (the ability to construct reduced-cost housing). A return on investment of two years is expected, following implementation of commercial exploitation. Product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AMPSS – Advanced Micro-propulsion for Small Satellites' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The innovative micro-propulsion system AMPSS is a key enabling technology aiming to provide small satelliteplatforms with a powerful, yet cost-efficient, on board propulsion system to commercial and scientific operatorsof constellations for orbital lifetime extension and constellation management purposes.AMPSS outperforms all other systems currently on the market with its unique combination of high-performance,high efficiency, low fuel and power consumption, low specific mass, volume and complexity, high safety and incombination with a very attractive price.There will be around 1,190 small satellites in 2025, of which about 830 satellites (70%) will be in constellations.Thus, the small satellite propulsion system market value will be at about 200 M€ in 2025.In addition, the low-cost electric small satellite propulsion systems proposed by the BerlinSpace Consortiumwill enable national governments of all countries, even development countries and emerging economies, tobuild up their own small satellite constellations for Earth observation or communication purposes and usethem for their economic benefits in application domains such as National Security, Agriculture, Forestry,Natural Resources, Disaster Monitoring and much more.The company plans on using the information acquired during this Phase I to run large-scale pilot studies in realcase scenarios and prepare for full market launch – after completing the Phase 2 of the SME Instrument as well- with communication and commercialization activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Centre for design and structure in biology' (CDSB).

assistant: **Concept**

Description:The Infrastructure offers access to its installations in the field of structural biology. As far as NMR is concerned, this includes 185 man-days of access to the three high resolution spectrometers (Varian INOVA 750, 600 and 500) including100 man-days computing, the 500 MHz instrument also being equipped for solid-state studies. The (automatic) crystallization and X-ray diffraction facilities, including two rotating anode generators and three area detectors, will be available for 225 man-days including 100 man-days computing. The electron and high-end light microscopy installations for 210 man-days being equipped with transmission electron, field emission scanning electron and scanning probe microscopes, including 33 man-days computing, as well as a video- enhanced and a fluorescence microscope. 22 man-days will be available at the CDSB synchrotron DESY Hamburg, (starting January 2001). For sample preparation, facilities for gene expression, including a microbiology laboratory with a 10l fermenter, are available within the Centre. Isotope-labelled proteins can be expressed, and labelled oligonucleotides can be synthesized in vitro using T7 RNA polymerase. Proteins and nucleic acids can be purified using one of three FPLC or two HPLC machines as well as isoelectric focusing and other standard equipment. Finally, up to 15% of the state-of-the-art computing resources of the Centre will be available for the users. Access will be provided free of charge to designated user groups and this will include infrastructural, logistical, technical and scientific support. The Infrastructure also offers practical courses for users who are not experienced in one or more of the techniques available for structure determination.Application:Proposals can be submitted anytime fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms of Antibiotic Recalcitrance in ESKAPE pathogens', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Antimicrobial resistance (AMR) is the silent pandemic uprising for the past decades that challenges practitioners to everyday life. In this context, more and more infections have become harder to treat, even in absence of genetic markers for AMR. This phenomenon, called recalcitrance, is related to the ability of susceptible bacteria to overcome antibiotic treatment and to reinitiate infection contributing to antibiotic failures and resistance emergence. Previous studies have described the involvement of a phenotypic switch leading to recalcitrance but underlying mechanism remain poorly understood. ESKAPE (standing for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) pathogens are the most prevalent causative agents in common recurrent healthcare-associated infections as well as well-known for their multidrug resistant phenotype and are the best candidates to understand recalcitrance. Hereby, we propose to investigate two of them, E. faecium (Efm) and E. cloacae complex (Ecc) by studying the proteome involved in recalcitrance. To identify any protein and/or pathway of interest, we will (i) identify which stress and bactericidal antibiotic induce recalcitrance both in Efm and Ecc; (ii) evaluate proteome and phosphoproteome of isolated antibiotic-recalcitrant bacteria; and (iii) confirm functionality of candidate proteins/pathways by mutagenesis and phenotypic approaches (in vitro and in cellulo) with the expertise of  Prof. Helaine at Harvard Medical School (HMS) in Boston (secondment). Finding potential protein targets can highlight new candidates to further develop new therapies to overcome the rising of AMR.


**Keywords:** Mass spectrometry, Recalcitrance, ESKAPE pathogens, Anti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Anti-Parasitic Drug Discovery in Epigenetics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This proposal builds on the proven methodology developed in the SEtTReND FP7 project to develop inhibitors of schistosome HME as lead compounds for new drugs. We will employ a target-based strategy for the development of novel drug leads against schistosomiasis, leishmaniasis, Chagas disease and malaria by targeting histone modifying enzymes (HME), in particular those involved in acetylation/deacetylation and methylation/demethylation. The principal objectives of A-PARADDISE are:- The identification of HMEs from Leishmania sp. and Trypanosoma cruzi and the molecular characterization and functional characterization of selected potential targets,- Phenotypic screening of Leishmania, T. cruzi, S. mansoni and P. falciparum using HME class inhibitors, inhibitors developed specifically against S. mansoni and P. falciparum HMEs. This will permit us to obtain a comprehensive view of inhibitor classes and chemical scaffolds of interest,- Production of recombinant Leishmania and T. cruzi HME proteins, structural studies. Selected, validated target enzymes will be produced, crystallized and analysed by X-ray diffraction. Assays will be optimized to permit testing of inhibitors,- High-throughput and structure-based (in silico) screening of selected HMEs. Inhibitors selected will be further screened by phenotypic assays on the parasites in vitro,- Optimisation of inhibitor structures by chemical synthesis based on molecular modelling studies (inhibitors of all origins),- Transcriptomic analysis of drug-treated parasites to verify target specificity and mechanism of action (all parasites),- Pharmacological and toxicological studies (in vitro and in vivo) of selected inhibitors, in vivo testing of compounds in parasite-infected mice.The overall objective of the A-PARADDISE project is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced MUltimedia SErvices for residential users' (AMUSE).

assistant: **Innovation**

The aim of the AMUSE project is to carry out experiments on the provision of interactive and distributive multimedia services to real residential users (in the order of ten per trial island). Services will be demonstrated in field trials carried out in different islands, using a state-of-the-art end-to-end ATM infrastructure (from Terminal Equipment to Multimedia Server), through various types of Access Networks.A number of experiments are planned to thoroughly assess both service and technology aspects related to the adopted delivery platforms.Demonstration of multimedia services delivered to real residential users through trials using experimental platforms: the first trial started in Munich on May 14, 1996 and closed on August 19; the second trial started in Milan on September 9 and is still running; the third trial started in Basel on October 21 and closed on January 20Experiments on trial interconnection (Italy/Portugal, Germany/Switzerland)Design and development of a first set of diverse appealing applications, with attractive contents ensured by a number of content providersAssessment of preliminary results of trials and experiments: positive indications in terms of infrastructure performances and user acceptance of the offered servicesDissemination, exploitation and advertising of the activities carried out and the results obtained, and contributions to standards bodies, publications, press releases, presentations and demonstrationsIntegration of platforms for trials in Reykjavik and Mons (start 1997)Specification of up-graded ADSL access technology for advanced Phase 1Development and integration of functionalities/units for Switched Video Broadcasting (SVB)Preliminary Requirements specification of Network Architecture, Interfaces and Services for Phase 2Develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on '2nd International Conference on The Navier-Stokes Equations: Theory and Numerical Methods'.

assistant: **Innovation**

The Navier-Stokes equations describe the motion of the usual fluids like water, air, oil under quite general conditions. They are the base of the mathematical models of important phenomena in many areas of science and technology. While the physical model leading to the Navier-Stokes is simple their understanding, from mathematical point of view, remains fundamentally incomplete. Anyway the study of this equations has stipulated and influenced treatment, improved and refined the methods of research in partial differential equations. Rightly, they are one of the most celebrate system of equations of Applied Mathematics. Recently, due to the progress in Marthematical Analysis and Computer Science the research on Navier-Stokes benefited of a rivitalizing attention. The last years have brought bulk of achievements survey articles, books and an increasing number of research papers. Further, numerical and computational methods become another focus for the applications of the basic theory. The Navier-Stokes equations are studied in all parts of the world and in all areas of research that are intimately connected with the basic mathematical theory of the equations. It is clear that the attempt to understand the equations and in general the nonlinear problems will dominate large parts of mathematics in most areas of science and technology in the future years. The topics of the Conference move around actual research on the qualitative theory, the progress performed in the flow with free surface and the relevant results on the theory of compressible fluids. A significant part is played by the numerical methods and industrial applications.The purpose of the Conferences in Varenna, initiated in 1992, are the following: - to promote, encourage, and influence more cooperation in the wo