RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ANTIcipating the Global Onset of Novel Epidemics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In recent years, an increased number of zoonotic viruses and bacteria have crossed the species barrier to humans and caused or threatened to cause human pandemics with high morbidity and mortality. Because of our inability to predict the emergence of these pathogens, it is difficult to take preventive measures. It is known that zoonotic pathogens need to cross barriers at the animal-human interface, at the pathogen-host interface within humans, and at the human-human interface before they can cause a human pandemic. However, it is poorly understood which pathogen, host, arthropod vector, and environmental factors allow zoonotic pathogens to successfully cross these barriers. Therefore, our overall objective is to identify the key factors that render zoonotic pathogens prone to cross the species barrier and gain efficient transmissibility among humans. ANTIGONE has a two-pronged approach to reach this objective. First, we will perform primary research studies to fill important gaps in our understanding of how zoonotic pathogens can gain pandemic potential. These studies will focus on selected viruses and bacteria, including SARS coronavirus, , Crimean-Congo haemorrhagic fever virus, Nipah virus, Ebola virus, E. coli, M. bovis, B. burgdorferi, C. burnetii and S. suis. Integral to these activities will be a cross-disciplinary training programme for young scientists (Young ANTIGONE) and a web-based pathogen information sharing platform. Second, we will organize Dahlem studies where experts from the human and veterinary fields, from within and outside ANTIGONE, will discuss key issues in infectivity, pathogenicity, and transmissibility of zoonotic pathogens and determine general criteria to assess the risk of these pathogens to gain human pandemic potential. Together, the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regulation and structure-function analysis of the rat and human serotonin transporter', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content In the central nervous system, serotoninergic neurotransmission is terminated by the rapid re-uptake of the neurotransmitter serotonin out of the synaptic cleft back into the presynaptic terminal. This translocation is mediated by a substrate specific protein, the serotonin transporter (SERT). This polypeptide represents the target site of different classes of antidepressants which inhibit serotonin re-uptake and are widely used for the treatment of depression. In addition, SERT is also the target of drugs of abuse such as cocaine or methylenedioxymethamphetamine (MDMA ecstacy"). However, the molecular basis of the pharmacological effects and interactions of these compounds are only poorly understood. My objective is a contribution to a better understandig of the mode of action of different antidepressants on the function of the serotonin transporter molecule. This includes: - identification of molecular determinants of antagonist binding sites on SERT (this includes a strategy which directly combines pharmacological analysis of SERT mutants with photo-affinity labelling studies). - long-term regulation of the function of SERT by antidepressants Training content (objective, benefit and expected impact) Based on my expertises in molecular neurobiology, in the Biochemistry department I will provide training for five graduate researchers and two post-docs in the research group of. Dr.C. Williams in neuronal transporter research wich includes : - transient expression of the human and rat serotonin transporter protein - generation of a stable cell line, permanently expressing the human serotonin transporter - performing site directed mutagenesis of SERT with following pharmacological analysis - synthesis and use of photo-affinity substrate ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cell-targeted Biophotonic Nanoparticles for Vision Restoration' (NanoFlash).

assistant: **Concept**

NanoFlash aims to develop disruptive nano-enabled technology to restore damaged neuronal networks through precise stimulation of specific retinal cells. Focusing on non-genetic reactivation of physiological vision, NanoFlash targets treatment of retinitis pigments (RP) and age-related macular degeneration (AMD), both marked by severe retinal degradation and loss of high-resolution vision. Current retinal prostheses suffer from low resolution and indiscriminate activation of inner retina, while ontogenetic strategies targeting ON-bipolar cells (BCs) face significant limitation in efficacy and translational readiness.Circumventing these challenges, NanoFlash will engineer photovoltaic polymer nanoparticles (NPs) functionalist to target mGluR6 receptors, a unigue hallmark on PN-BCs. Using state-of-the-art modelling and bioelectronic in vitro platforms, the project will drive the rational design and optimisation of NPs, tailoring their size, architecture, spectral sensitivity, and transduction efficiency. Advanced organ-on-chip devices will be developed to screen and validate NP targeting and retinal reactivation performance in retinal organdies and explants. Lead NP candidates will then be tested in rod-cone degeneration rodent models, assessing targeting precision, suspension stability, and visual restoration outcomes. NanoFlash represents a major leap forward in retinal prosthetics by restoring the ON/OFF pathway segregation critical for spatial resolution, contrast sensitivity, and motion detection. This highly interdisciplinary effort will push the frontiers of bio-organic optoelectronics and neurophysiology, providing essential preclinical data toward therapies for currently incurable retinal diseases, addressing a pressing unmet medical need in the EU.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'X-linked Adrenoleukodystrophy (X-ALD): pathogenesis, animal models and therapy' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Our ultimate goal is to develop new therapies for X-linked adrenoleukodystrophy (X-ALD), the most frequent inherited monogenie demyelinating disease of the central nervous system (1:18,000). X-ALD is characterised by extensive phenotypic variability, which is not correlated to ALD genotype, and leads to death in boys due to cerebral demyelination and to motor disability in adults due to spinal cord degeneration. Allogenic bone marrow transplantation, proven to be beneficial in X-ALD, can be applied only to a limited number of X-ALD patients. Thus, there is no treatment for the majority of patients, in particular those with the severe cerebral form of X-ALD and adults with adrenomyeloneuropathy (AMN). Understanding of the pathogenesis is necessary for the development of novel therapeutic strategies. The still unresolved transporter function of the ALD protein will be studied in reconstituted liposomes. To get further insight into the pathogenesis of X-ALD, we aim to identify genes and proteins that are differentially regulated in the target tissues of patients with cerebral ALD and AMN using Affymetrix analysis of differential mRNA expression and a proteomics approach based on MALDI-TOF mass spectrometry. Additional genome-wide approaches such as mapping of quantitative trait loci will be applied to identify modifier genes that may contribute to the phenotypic variability of X-ALD. We will generate new mouse models that represent a wider phenotypic spectrum of the disease for a more efficient evaluation of therapeutic strategies...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TROPHIC RESOURCE DYNAMICS IN BATHYAL DEMERSAL COMMUNITIES' (TROBAT).

assistant: **Innovation**

The primary aim of this project is to understand the structure and function of biological communities on the deep (200-2000m) European ocean margin. These communities are being increasingly subjected to human impacts (fisheries, oil and gas production, po llution from terrigenous sources). There is an urgent need to study the tropic relationships between benthic and benthopelagic organisms in order to guide policy for the sustainable use of ocean margin ecosystems. Trophic relationships provide essential in formation on biological interactions for management strategies. Hence, the main objectives are to study population structure and production of benthic/benthopelagic communities and their trophic interactions in order to evaluate 1) what food sources are ex ploited by deep-sea demersal fish and crustacean species of commercial value and 2) how ecosystems might change in response to human impacts. The specific objectives are: (i) to study the dynamics (abundance, biomass, diversity) of suprabenthos (near botto m) zooplankton communities, (ii) to estimate their secondary production, (iii) to determine food web structure and (iv) to produce the FIRST predictive models of secondary production and P/B for bathyal ecosystems. Through models the project aims to unders tand the likely consequences of any changes in the dynamics of bathyal ecosystems. These objectives will be achieved within larger national and EU-funded multidisciplinary projects comparing ecosystems in different biogeochemical settings in the Northeast Atlantic and the Mediterranean Sea. The work proposed complements the aims of these larger programmes and will gain added value from them. Training will be gained in bathyal ecosystems, biochemical analyses and modeling, through multidisciplinary workshops and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Enabling IP multimedia services convergence over next generation networks technology'.

assistant: **Objectives**

The IP Multimedia subsystem is an overlay system, that will serve the convergence of mobile, wireless and fixed broadband data networks into a common network architecture where all types of data communications will be hosted in all IP environment using the SIP protocols infrastructure.As recent public trials have shown, IMS technology still suffers a number of confining factors mainly associated to:1) Interoperability with underlying communication technologies and legacy infrastructures: IMS should be interoperable not only with the existing circuit switched legacy infrastructures, but also with the various versions of existing packet technologies.2) Unified resources allocation mechanisms across heterogeneous networks: Guaranteeing a certain type of Quality of Service for a given set of IMS services in end-to-end manner, requires prior invocation of underlying resources negotiation and allocation mechanisms of each network type involved in the context of the call.3) Terminals IP-level mobility management: Designated to deploy its services over a mixture of network technologies including wireless, mobile and fixed access, IMS should be able of dealing sufficiently with the important issue of terminals mobility management which nowadays is tackled at physical interface level, and results in services robustness weakening and increased probability of disrupted communication.Building on the results of past and ongoing IST projects related to the research on IMS technology, VITAL aims at consolidating the technological framework that will enable the smooth transition of multimedia communications, including voice, from circuit to packet switched domain of the communications. With respect to this goal, the project will setup an experimental IMS distributed platform, elaborate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DEVELOPMENT OF NOVEL INSPECTION TECHNIQUES FOR TRAIN AXLES'.

assistant: **Concept**

The structural integrity of wheel sets used in rolling stock is of great importance to the rail industry and its customers. A number of rail accidents have been directly related to the failure of train axles, leading to increased demands for their inspection and maintenance. Visual inspection and Magnetic Particle Inspection are the current standard practices used for manual non-destructive testing of axles. However, these processes require removal of the wheelset from the wagon/locomotive bogie and full disassembly in order to facilitate access.  Inspection is also carried out by some wagon providers using ultrasonic testing (UT) but its application is also limited to disassembled wheelsets.An axle on a wheelset can be connected to a number of ancillary components including breaks and bearings. The disassembly (and reassembly) of axles from the wheelsets/wagon bogey is therefore very time consuming and expensive. There is evidence that even partial disassembly and reassembly could introduce future axle reliability problems. To minimise disruption to their train services but ensure continued safety, train operators require frequent and regular inspection methods that allow quick inspection at the depot with the minimum of wheelset and bogie disassembly.The AxleInspect project aims to develop new inspection techniques based on phased array ultrasonic and electromagnetic techniques suitable for the inspection of both solid and hollow axles. For solid axles, inspection techniques are to be developed that inspect from the end face of the axles using new and novel phased array ultrasonic inspection technology. For hollow axles, probes based on UT and electromagnetic inspection techniques are to be developed, enabling detection of surface breaking cracks that cannot be found
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Interactive and Immersive Video from Multiple View Images' (INVIEW) targeting Fifth Framework.

assistant: **Abstract**

The ultimate goal of INVIEW is to create a new way of visualizing environments, which will be implemented as a client-server final application. The goal of the server application will be to produce all the related data structures, so that the client visualization tool can navigate arbitrarily through the environment giving the subjective impression that the end user is in the middle of the environment. We will demonstrate the results in two pilot applications: - one related tele-medicine, and - an accidents inspection tool.OBJECTIVESThe ultimate goal of INVIEW is to create a new way of visualizing environments, which will be implemented as a client-server final application. The goal of the server application will be to produce all the related data structures, so that the client visualization tool can navigate arbitrarily through the environment giving the subjective impression that the end user is in the middle of the environment. We will demonstrate the results in two pilot applications: - one related tele-medicine, and - an accidents inspection tool.DESCRIPTION OF WORKA work plan composed of 9 work-packages has been detailed:1. Project Management2. System Specifications3. Image Acquisition4. Viewpoint Related Computations5. Scene Related Computations6. Generation of Novel Views7. System Integration and Applications Development8. Evaluation, Refinement and Testing9. Exploitation and Dissemination In order to provide a tool which will permit to immersively visualize environments, and navigate trough them in an arbitrarily way, the consortium will apply much of the technology and research developments of computer vision, modifying and enhancing substantially some aspects to fit the goal of the project. All the developments produced in the technical workpackages will be i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Origination of novel gene regulatory networks in the evolution of mammalian pregnancy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

One of the deepest unanswered biological questions is how new phenotypes arise in evolution. To address this question, I propose to investigate a major mammalian innovation: pregnancy. Phenotypic novelties of pregnancy include efficient placental delivery of nutrients and internal fetal development. When being established, these novelties were associated with major gene regulatory changes in the endometrium of the uterus. My preliminary studies in human endometrial cells suggest that aryl hydrocarbon receptor (AHR) regulates genes that are essential for placental development and maternal immunotolerance of the fetus. It is also known that AHR evolved endometrium-specific expression early in the mammalian ancestor and acquired the ability to repress estrogen signalling necessary for implantation only in placental mammals. Here, I propose to study the origination of novel endometrial gene regulatory networks of AHR. I will establish the full endometrial target gene sets of AHR in major placental lineages and a non-placental out-group (opossum). Potential AHR targets will be validated in endometrial cells using knockdowns and reporter assays. The results of this study will provide a paradigm for understanding how transcription factors integrate into a new cell-signalling network. The findings will also expand our knowledge of the mechanisms of AHR-mediated toxicity of dioxins in mammalian reproduction and may reveal new therapeutic targets for the treatment of female reproductive disorders such as preeclampsia and endometriosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cortical Representation of Abstract Semantic Knowledge' in the context of a Horizon 2020 call.

assistant: **Objectives**

The study of semantic memory considers a broad range of knowledge extending from basic elemental concepts that allow us to recognise and understand objects like ‘an apple’, to elaborated semantic information such as knowing when it is appropriate to use a Wilcoxon Rank-Sum test. Such elaborated semantic knowledge is fundamental to our daily lives yet our understanding of the neural substrates is minimal. The objective of CRASK is to advance rapidly beyond the state-of-the-art to address this issue. CRASK will begin by building a fundamental understanding of regional contributions, hierarchical organisation and regional coordination to form a predictive systems model of semantic representation in the brain. This will be accomplished through convergent evidence from an innovative combination of fine cognitive manipulations, multimodal imaging techniques (fMRI, MEG), and advanced analytical approaches (multivariate analysis of response patterns, representational similarity analysis, functional connectivity). Progress will proceed in stages. First the systems-level network underlying our knowledge of other people will be determined. Once this is accomplished CRASK will investigate general semantic knowledge in terms of the relative contribution of canonical, feature-selective and category-selective semantic representations and their respective roles in automatic and effortful semantic access. The systems-level model of semantic representation will be used to predict and test how the brain manifests elaborated semantic knowledge. The resulting understanding of the neural substrates of elaborated semantic knowledge will open up new areas of research. In the final stage of CRASK we chart this territory in terms of human factors: understanding the role of the representational s