RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microbial diversity in aquatic ecosystems, novel microorganisms and their potential applications' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Molecular, mainly DNA based tools allow to study and facilitate studies in time and cost effective way on any microbial communities, e.g. aquatic, soil, human microflora etc., without the need for extensive cultivation. However, cultivation remains the main tool in studying physiology and other specific properties of microorganisms.Aims of the project:- Molecular characterization and isolation of novel microbes from the humics rich aquatic ecosystems such as pristine peat bogs ponds, humic lakes and rive rs.- Optimization of DNA extraction and purification from humics rich environmental samples;- Screening for novel secondary metabolites and their application in biotechnology and biomedicine.The applicant will return to his home country after finishing his Marie Curie Individual grant (Cat 30) and will establish a new interdisciplinary team at the Institute of Technology at Tartu University (IT TU) in Estonia. Interdisciplinarity between molecular biology, microbial ecology, and environmental microbiology will be introduced.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Investing in Europe'.

assistant: **Innovation**

The financial crisis of 2008 quickly turned into a debt crisis of Europe by 2010. On one hand, there are millions of people suffering due to austerity measures, which results in severe cuts both in public and private spending, on the other hand, there are economies which find it, extremely hard to grow. Unfortunately, there is a big dilemma and a self fullfilling probhecy regarding this huge economic crisis. The problem of Europe is simple. There are staggering national debt of european countries, there are huge budget deficits, and shrinking economies do not supply enough money to the system. What is urgently needed is attracting investment to the. However, to pay national debt, governments need to cut spending, which in turn, sharply cuts into the growth of the companies, and which in turn, stops investment to the eurozone due to lack of confidence. This is a deadly loop, which proves harder by the day to get out. There is one point, which every economist and academic agrees upon; that is, Eurozone needs investment that will flow into the private companies. However, world wide investors have other options such as investing in emerging countries. Even though there is no academic rationale, investors put significant amount of their investment to the emerging economies, rather than where it is needed: Europe. Despite an admirable performance of equity markets in emerging economies, the classical portfolio selection rules (such as the mean-variance and stochastic dominance rules) cannot identify a preference between emerging and European markets, creating an inconsistency between investors' asset allocation decision and modern portfolio theory. The main research objective of this project is to use recently developed investment rules and identify specific European markets,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Early diagnosis and analysis of the genetic causes of primary pulmonary hypertension (pph), a rare and life- threateting disease' to be submitted under Fifth Framework.

assistant: **Abstract**

Primary pulmonary hypertension (PPH) is a rare, progressive disease that may serve as a model for pulmonary artery remodelling. Autosomal dominat mutations of the bone morphogenetic protein receptor 2 gene have recently been identified in 50% of patients with familial disease and in 25% of sporadic cases. The aetiology of PPH in the other patients remains unclear. Early diagnosis is crucial for therapy. In this proposal of 7 European PPH centres we will establish a European PPH registry and analyse further genetic causes of the disease. For early diagnosis of PPH family members of PPH index patients will undergo non-invasive screening (Dopller echocardiography during exercise an/or hypoxia; spiroergometry) as well as genetic analysis. Furthermore, we will study PPH phenotypes, genotype/phenotype correlations, the course of disease, and options for treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Grid computational chemistry'.

assistant: **Innovation**

The challenges in modern Computational Chemistry covering phenomena of long time scales, from femtoseconds to seconds, and large spatial scales, from small molecules to biopolymers, could be tackled by the emerging Grid computational technology. This allows one to employ hundreds of computers as a seamless, integrated, computational and collaborative environment embracing different categories of distributed systems.The computational chemistry group at the University of Perugia has already taken this direction and created the Italian Chemistry Grid, CHEMGRID. They will be the main partners in transferring their knowledge to Theoretical and Computational Chemistry in Crete to build an intragrid in Crete, and together with the University of Antwerp will apply new algorithms suitable for Grid computing in the field of Quantum and Classical Molecular Dynamics. Subsequently, we shall be able to join and utilize larger Grids (as the European Grid) having at hand both codes and expertise.This ToK is a four-year project and it will be realized in five Phases. In Phase 1 we create a local Grid in Crete in order to acquire the necessary knowledge in installing and operating a Grid middleware such as GLOBUS. In Phase 2 we shall develop a computer code to study the quantum dynamics of polyatomic molecules. Phase 3 involves the construction of a computer code for classical molecular dynamics suitable to search for specific orbits (rare events) in large molecular systems. Phase 4 is devoted to applications. In the final phase, Phase 5, we will report the results.Three experienced researchers will be employed: one expert in high performance computing, one expert in classical and one in quantum dynamics. With the completion of the project all participating groups will become more compet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SEMI-DISPOSABLE INSULIN PATCH PUMP: THE BEST SOLUTION FOR DIABETES PATIENTS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Diabetes is the second more frequent disease in the world with around 422 M cases and about 12% of global health expenditure. Many patients, mostly with type I diabetes, depend on insulin delivery to have a high-quality life and need comfortable, wearable, easy to use and cheap medical devices. In Europe, about 60 M people have diabetes and more than 71 M are estimated by 2040. Around 6 M Europeans have type I diabetes from which about 140.000 are children (the highest world prevalence), making it an European health prority.AMF develops, manufactures and sells microfluidics components for high performance applications. We aim to offering a new solution for insulin treatment for diabetes patients and we have developed a microfluidic technology to serve as a basis for our semi-disposable insulin patch-pump. The use of our intelligent, compact and cost-effective DiAMS will disrupt the field of insulin delivery and make it a safer, more reliable and more mobile for care in hospitals and at home solution. Our system is practically invisible, composed of a patch pump, a continuos glucose monitoring (CGM) and a management interface through a LiNK component that can be controlled through the smartphone. The business opportunities are tremendous because today only Insulet Corporation and Roche offer a product on the patch-pump market, which despite its moderate success have opened the door and let us strongly compete in it thanks to our partially disposable concept and the use if orefilled insulin cartridges. Our technology has many potential applications in drug delivery in the future. DiAMS takes into account the European challenges by making the insulin treatment easier, cheaper, more accurate and more comfortable to patients. In phase 1 we plan to build a detailed feasibilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Monitoring crustal stress state frOm 4D sEismic iMaging' (MODEM) under Horizon Europe.

assistant: **Objectives**

Tectonically active crustal settings such as volcanic fields and seismogenic fault systems are characterized by evolving stress critical conditions that can be detected by continuously measuring isotropic and, more importantly, anisotropic elastic properties. This is because these observables are strongly sensitive to the opening of fractures and to the infiltration and migration of magma and crustal fluids, which are more prominent before major volcanic eruptions and earthquakes. With this respect, the team members of the ERC StG 758199 NEWTON are currently finalizing a novel 4D seismic imaging technique that allows the automatic detection of relevant changes in the crustal isotropic and anisotropic structural patterns and, by inference, of the crustal stress state. The new seismic inversion strategy has been tested with synthetic and real seismic datasets from the Etna volcanic field, with results indicating that it can detect robust changes in seismic anisotropy related to variations in the crustal stress state preceding volcanic eruptions and local earthquakes.Given the current limited capacity to determine the evolving plumbing system dynamics (which, in turn, hampers the forecasting of major paroxysmal events), the activities of MODEM will focus on the development and distribution to volcano observatories of an open-source software which will include the novel methodology for monitoring the crustal structure and stress state evolution in volcanic fields. The software will be firstly validated and integrated with the monitoring apparatus of the Etna volcano, and subsequently disseminated over other European and international volcano observatories. As the monitoring system can be applied to any crustal setting, our future goal is to commercialize the software provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improved rheological characterisation of ceramic slips and glazes using zeta potential measurements' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The characterisation and quality control of materials used in the whitewares industry for production processes is critical to ensure high yields. At present the ceramic industry relies heavily on the preparation, processing and use of a wide variety of aqueous suspensions of clay and mineral powders. Currently the rheology of these is controlled by torsion viscometry and density data but these methods are somewhat crude and often give poor results. By the use of Zeta Potential as a quality control and research tool it is intended to reduce losses caused by the use of unsuitable products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DNA binding proteins for treatment of gain of function mutations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Zinc finger (ZF) and transcription activator-like effector (TALE) based technologies are been allowing the tailored design of “artificial” DNA-binding proteins targeted to specific and unique DNA genomic sequences. Coupling DNA binding proteins to effectors domains enables the constitution of DNA binding factors for genomic directed transcriptional modulation or targeted genomic editing. We have demonstrated that pairing a ZF DNA binding protein to the transcriptional repressor Kruppel-associated box enables in vivo, the transcriptional repression of one of the most abundantly expressed gene in mammals, the human rhodopsin gene (RHO). We propose to generate RHO DNA binding silencers (“AlleleChoker”), which inactivate RHO either by transcriptional repression or targeted genome modification, irrespectively to wild-type or mutated alleles (mutational-independent approach), and combine RHO endogenous silencing to RHO replacement (silencing-replacement strategy). With this strategy in principle a single bimodal bio-therapeutic will enable the correction of any photoreceptor disease associated with RHO mutation. Adeno-associated viral (AAV) vector-based delivery will be used for photoreceptors gene transfer. Specifically our objectives are: 1) Construction of transcriptional repressors and nucleases for RHO silencing. Characterization and comparison of RHO silencing mediated by transcriptional repressors (ZFR/ TALER) or nucleases (ZFN/ TALEN) to generate genomic directed inactivation by non-homologous end-joining (NHEJ), and refer these results to RNA interference (RNAi) targeted to RHO; 2) RHO silencing in photoreceptors. to determine genome-wide DNA binding specificity of silencers, chromatin modifications and expression profile on human retinal explants; 3) Tuning silencin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ALD-protected Next Generation Lithium-Sulfur battery Cell' in the context of a Horizon Europe call.

assistant: **Objectives**

The proposed project aims to revolutionize battery technology by developing Generation 5 batteries based on lithium-sulfur (Li-S) chemistry to meet the growing demands of mobility applications focusing on heavy-duty vehicles. This project will address critical challenges in battery performance, safety, and sustainability by innovating in materials, cell design, and manufacturing processes. By employing advanced techniques such as Atomic Layer Deposition and Molecular Layer Deposition, we will enhance the protection of lithium-metal anodes, thus overcoming the issues of a dendrite Li growth and low coulombic efficiency, which have hindered the commercialization of Li-S batteries so far.The consortium will develop scalable and manufacturable surface coatings, integrating these advancements into Li-S batteries to achieve higher energy densities, extended cycle life, and improved safety profiles. The project will also focus on creating batteries with designs that facilitate end-of-life recyclability, aligning with the European Union's objectives for sustainable and circular battery technologies.To ensure the practical application and scalability of these technologies, the project will evaluate the compatibility of the new manufacturing processes with existing lithium-ion production infrastructure. This will include proof-of-concept demonstrations at the small pilot line scale, paving the way for future commercialization and widespread adoption of Gen5 battery technologies in the automotive sector and beyond.The outcomes of this project will contribute significantly to the European Union’s goals of achieving a sustainable, circular, and competitive battery ecosystem, thereby supporting the broader objectives of the European Green Deal and the transition towards a climate-neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational ONcology TRaining Alliance' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cancer is a major cause of death and suffering, rendering it a huge concern to the general public. Consequently, it has been targeted by application of the molecular techniques developed during the last 20-25 years, thereby improving diagnosis and treatment. Nevertheless, although current biomarker and treatment concepts often are successful initially, they subsequently frequently fail to achieve durable drug response and long-term survival for cancer patients. The study of somatic evolution in cancer is a very promising approach to rectify this situation. Fortunately, single cell genomic sequencing has recently begun to provide opportunity to unprecedented detailed insights into tumour evolution and new techniques are emerging for assaying the spatial distribution of tumour heterogeneity. Analysing and developing methods for these emerging data sets are under-researched areas that lie at the intersection of medical, evolutionary biology, and computational research. In CONTRA, European researchers with complementary expertise have joined forces in order to collectively facilitate training of future European computational cancer researchers. We will by applying modern recruitment and selection methods in combination with offering excellent training and employments conditions, including social security, facilitate recruitment of 15 excellent ESRs, across genders and geographical areas.  We will train these 15 ESRs in the mathematical, computational, and applied skills required to tackle the complex analysis problems posed by somatic evolution in cancer. We will also teach them entrepreneurship and the requirements of pharmaceutical and biotech industry. Using a novel scheme, this substantial academic cancer expertise will be complemented with industrial expertise in softw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Marie Curie Training Network on Particle Detectors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The challenging questions of particle physics, like the origin of mass, the existence of new forms and states of matter, can only be addressed in technically complex and expensive large-scale research facilities. Well coordinated international effort is required to design, build and operate world class infrastructure comprising accelerators of highest energy and/or intensity and detector systems of unprecedented performance.  Frequently the quality of the results and hence the progress of science is limited by the quality of the detectors and by the level of understanding of their characteristics and performance. Future detectors need to cap current state-of-the art performance in terms of position and energy resolution, number and density of read-out channels, dynamic range and noise, speed, radiation tolerance, robustness and reliability. We propose an Initial Training Network on Particle Detectors which spans 4 years. A multi-site network has been formed which comprises 9  academic participants, 3 associated industrial partners and 2 associated academic partners from 9 European countries. It will provide extraordinary training opportunities to young researchers (physicists and engineers) in the field of radiation detectors. The proposed Training Network will play an essential role to train a new generation of excellent detector scientists which is required to conceive, design, build and exploit the next generation of experiments which may come into operation in the years 2012-2020. Internationally renowned supervisors will provide scientific and technical training at the highest level. The trainees will be integrated in existing collaborative structures and profit from a unique spectrum of expertise and facilities available in the network. Complementary training, inv