RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A European multicentre double-blind placebo-controlled phase III trial of nilvadIpine in mild to moderate Alzheimer’s disease' (NILVAD) under Seventh Framework.

assistant: **Objectives**

Alzheimer’s disease (AD) is an ever-increasing public health concern among the aging population and is the most common form of dementia affecting more than 15 million individuals worldwide and around 5 million Europeans. The direct and indirect costs of AD and other dementias amount to more than €440,000 million each year (www.alz.org, 2010).Even modest therapeutic advances that delay disease onset and progression could significantly reduce the global burden of the disease and the level of care required by patients. While there are symptomatic-based drug therapies available for AD, these medications do not prevent the disease process itself. There is therefore an imperative to develop new treatments for AD that have disease modifying effects.This double-blind placebo controlled study will test the efficacy and safety of nilvadipine in 500 subjects with mild to moderate AD over a treatment period of 18 months. There is a strong scientific rationale for this study: Nilvadipine, a licensed calcium channel enhances Aß clearance from brain and restores cortical perfusion in mouse models of AD. Nilvadipine is safe and well tolerated in AD patients and clinical studies with this medication have shown stabilization of cognitive decline and reduced incidence of AD, pointing to both symptomatic and disease modifying benefits. Male and female patients with mild to moderate AD aged between 50 and 90 with a range of medical morbidities and frailty will be included in the study. If this trial is successful, nilvadipine would represent an advance in the treatment of AD patients and would have a major impact on the health and social care costs incurred in Europe by this neurodegenerative disorder. Furthermore, the creation of the NILVAD network will support future clinical trials and r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biodiversity audit, propagation and sustainable exploitation of ced ars - cedrus spp - in the Mediterranean region' (1994-1998).

assistant: **Concept**

The main objectives are as follows :* To establish methodologies for identifying cedar genotypes and multiplying commercially elite material within a framework of an environmentally sensitive production system and with due regard to safeguarding and enriching the natural biodiversity.* To establish an integrated system across a circum-Mediterranean network of expertise which will allow cedars to be profitably utilized in a sustainable way.* To develop protocols to preserve the genetic diversity but also to identify and encourage sustainable exploitation of the most suitable genotypes in different circumstances and environmental conditions.* To define effective and efficient propagation systems which will allow planned plantings and sensitive development to proceed.* To combine modern biotechnological approaches with conventional methods for propagation and screening for drought tolerance, in order to cultivate productive genotypes in arid and semi-arid areas.Expected OutcomeWe expect to develop methodologies for identifying and multiplying cedar genotypes within a framework of an environmentally sensitive production system and with due regard to safeguarding and enriching the natural biodiversity. In other words to establish an integrated system which will allow cedars to be profitably utilized but in a truly sustainable way. We aim to be pro-active in furthering the planting of material to help conserve the biodiversity in Cedrus to ensure its conservation. The programme should lead to the furthering of our scientific knowledge of cedars and the dissemination of this knowledge. In particular, we aim to form an information Network by which the findings will be shared and wider interactions encouraged.The key activities envisaged are :* Assess and analyse, using molecula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PAWN - Full Biodegradable Disposable Baby Diapers' (PAWN) under Horizon 2020.

assistant: **Objectives**

About 40% of modern disposable baby diaper consist of super absorbent polymer (SAP), a component that is neither skin friendly nor biodegradable. As a result, each year 21 bn used diaper generate 10M tons of plastic waste in Europe. This waste ends up either in incinerations, where it does not provide a good calorific value due to the high liquid content of the used diapers, or in landfill (about 2.6M tons yearly). The industry as well as the consumers have been searching for eco-friendly alternatives for years, but the material mix in diapers and the high quality and safety requirements for baby products have made this undertaking impossible so far.There are biodegradable alternatives for the outer non-woven fabrics of the diaper, but these do not yet reach the comfort and skin-friendliness of standard PP-based materials. The situation is even worse for the superabsorbent core, for which no fully biodegradable alternative with satisfying absorbency is available. In the PAWN project, we will bring to the market the first disposable baby diaper that fulfils al requirements. For this aim, the consortium brings together Polygreen (Israel), a start-up company that has developed a biodegradable SAP, Avgol (Israel), a market-leader in non-woven materials, who will integrate a technology to make PolyPropylene materials biodegradable, Celltex (Slovakia), a producer of baby diapers, Wilogis (Germany), a distributor of eco-friendly hygiene products and Novis (Germany), specialists in waste valorization and life cycle analysis.Over 5 years, the PAWN project will generate €136M of revenues and €30M of profit. The project is highly profitable and will deliver a ROI of 6.66.


**Keywords:** baby diaper, biodegradable superabsorbent polymer, biodebradable polypropylene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Support for international rare disease research to serve the IRDiRC objectives'.

assistant: **Concept**

Research into rare diseases (RD) is badly needed as many patients still lack a proper diagnosis and most of them are left without an effective treatment. In addition, research in this area is very relevant from a scientific point of view as RD are model diseases for more common disorders and are strong drivers of innovation. However, research in this field faces some specific constraints stemming from the low prevalence that represents the defining characteristic of RD, the sheer number of RD and their high phenotypic heterogeneity.It is now recognised that a global coordination of efforts is necessary to avoid duplication, fragmentation, redundancy and gaps in RD research, and to ensure that the results obtained can be rapidly translated into diagnostics and treatments to benefit  patients. This awareness has led to the launch of IRDiRC, whose mission is to coordinate and foster international collaborative research on RD, with the ambitious objectives of developing 200 new therapies and producing diagnostic tools for a majority of RD by 2020.The objective of SUPPORT-IRDiRC is to provide organisational and communication support to IRDiRC and thereby contribute to the development of policies and guidelines aimed at accelerating research on RD and reinforcing international research cooperation. To this aim, SUPPORT-IRDiRC has gathered together a group of motivated and highly experienced investigators who will work together during 6 years to help IRDiRC members remain on the right track in order to reach its ambitious objectives.SUPPORT-IRDiRC will work in close collaboration with the European Commission, research funding agencies from all countries involved, as well as with research projects contributing to the achievement of IRDiRC objectives, with a special focus on pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INFRARED BAKING EQUIPMENT FOR THE THICK FILM PHOTORESISTS' (IR-BAKER) under Fourth Framework.

assistant: **Objectives**

IR baking equipment and corresponding baking processes are planned to be applied for drying thick polymer layers (photoresists) on various substrates in shorter times and with reduced energy consumption. The main application field for the new equipment and processes are microelectronics and microsystem technologies. Other industrial applications are possible and are planned to be established on the market. After drying, thick photoresist layers can be patterned by using a UV lithographic process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Best Practice Factory for Freight Transport' under Seventh Framework.

assistant: **Concept**

The BESTFACT objective is to develop, disseminate and enhance the utilisation of best practices and innovations in freight logistics that contribute to meeting European transport policy objectives with regard to competitiveness and environmental impact.BESTFACT builds up on the work of BESTUFS, PROMIT and BESTLOG and integrates four interrelated areas of the key freight logistics challenges the European Union is confronted with and creates coherence with the key actions of the Freight Logistics Action Plan: urban freight, green corridors and co-modality, transport related environmental issues and eFreight.BESTFACT will establish a robust and replicable methodology for collecting and processing best practices. Best practice is understood as the combination of three dimensions: (1) the identification, evaluation and prioritising of relevant business cases. (2) the credible knowledge management of best practices and (3), the utilisation and implementation within existing or new industrial realities.The BESTFACT best practice methodology comprises a three-level approach that includes the set up of a comprehensive best practice inventory for which 160 cases will be analysed providing a general description. 60 in depth surveys will be made including a detailed analysis of the best practice cases. The development of best practices will be addressed in 5 best practice implementation actions stimulating modal shift on company or regional level, co-operation among stakeholders or the introduction of best practices into administrative procedures. Practical best practice handbooks as well as research and policy recommendations addressing new and additional policy tools will be provided. BESTFACT will organise 12 cluster workshops and 3 conferences. Furthermore, a comprehensive know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Engineering fibroblast-targeted mRNA therapies as clinically-focused adjuvants for unlocking tissue regeneration in arthritis' (Nano-Synergy) targeting Horizon Europe.

assistant: **Abstract**

As a Marie Skłodowska-Curie (MSC) fellow, I aim to engineer clinically focused mRNA formulations for rewriting the biology of synovial cells and unlocking regeneration in rheumatoid arthritis, and expand the capabilities of current Disease Modifying Anti-Rheumatic Drugs (DMARDs). The current first-line therapies for rheumatoid arthritis (RA), DMARDs, effectively manage inflammation but do not regenerate destroyed bone tissue, leading to lifelong disability and pain. We hypothesize that reprogramming specific synovial cell types by combining targeted mRNA delivery with approved DMARD therapies can restore the pathological tissue state in arthritis back to a healthy state and enable long-term joint repair. This project, Nano-Synergy, will be supervised by global leader in materials chemistry and tissue engineering Prof. Dame Molly Stevens at the Kavli Institute for Nanoscience Discovery (University of Oxford). I will collaborate with tissue biologists Prof. Chris Buckley and Prof. Mark Coles at the Kennedy Institute of Rheumatology (University of Oxford), the world’s premiere rheumatology research centre. In the host Stevens group, I will rationally engineer mRNA nanodelivery systems which specifically deliver payloads to joint synovial cells by using bio-orthogonal chemistry and revolutionary techniques for characterizing nanoparticle physicochemical properties. I will demonstrate that mRNA synergizes with DMARDs to reprogram arthritis at the cellular level by adapting a state-of-the-art organoid system utilized by Buckley and Coles which spatially and transcriptionally recapitulates human arthritis, and then demonstrate tissue regeneration using an animal model. In summary, as a biomedical engineer and immunologist trained in RNA delivery and animal models of tissue inj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Rain Forest GreenHouse Gases'.

assistant: **Concept**

RainForest-GHG aims to quantify ecosystem sinks and emissions of three major greenhouse gases (GHGs), i.e. carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O), in a tropical rainforest, and examine the contributions of the soil and the woody tissues to the ecosystem-scale GHG fluxes. RainForest-GHG further aims to determine the main environmental drivers responsible for the temporal and spatial variations of these GHG fluxes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanisms of ngf siganl transduction mediated by p75' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The proposed scientific project is about the role of p75 both in adult neural tissue and, especially, during neural development. Together with the tyrosine kinase type receptors it is a neurotrophin receptor. Until now, however, it has been ascribed only an accessory role in signaling of the tyrosine kinase type receptors. But recently it has been shown that nerve growth factor via p75 selectively can activate specific cellular responses (apoptosis, activation of nuclear factor kB as well as of the sphingomyelin cycle). It is the aim of this proposed study to shed light on these signal transduction mechanisms. First, an attempt would be undertaken to identify potential downstream binding partners of p75. Since p75 is capable of signalling via different pathways and has been shown to harbour various conserved (intracellular) domains, the relationship between certain domains and signaling pathways would be investigated. To do so, a systematic mutational analysis of the cytoplasmic moiety of p75 would be carried out. Effects of mutations would be analyzed by various functional assays specific for the single signalling pathways. Training content (objective, benefit and expected impact) In the course of this project, several molecular biological techniques would be applied: especially, a yeast two-hybrid system and BIAcoreTMtechnique for identification of binding partners, and in vitro-mutagenesis for generation of mutant receptor molecules would be used. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An Energy Efficient Air Conditioning systems with Temperature and Humidity independent controls based on the combination of a Liquid Desiccants Cycle with an adapted conventional air cooling system' (NANOCOOL) targeting Seventh Framework.

assistant: **Abstract**

Air-conditioning is a rapidly growing electrical end-use in EU. A/C systems reduce temperature of the ambient air while removing humidity. However such combined air conditioning/dehumidification is generally inefficient. A promising approach is represented by Hybrid Liquid Desiccant (HLD) systems, where the latent load is removed by a liquid desiccant dehumidifier, while the sensible load is removed by a conventional vapor compression air cooler. The heat required for regeneration of the liquid desiccants needs however to be provided by outer sources like natural gas or solar collectors. Furthermore almost all metal alloys are corroded by the most effective liquid desiccants. HLD systems are therefore not penetrating the market.Our goal is to develop an innovative HLD system in the range 100-200 kW, where waste heat from the condenser is used for regeneration of the desiccants. The energy demand by this process is 55% of the conventional technique. In cases of severe humid environments, like swimming pools, or kitchens, the energy savings can achieve easily levels of 65%-70%.Several innovative components have to be developed, namely: - Two multifunctional heat exchangers with high corrosion resistance for either water vapour absorption from the air flow or desiccant regeneration; - Development of a liquid-liquid heat exchanger with high corrosion resistance for desiccant regeneration process pre-heat (liquid-liquid desiccant). Based on the promising results of the FP7 Thermonano project, thermally conductive polymer nano-composites will be considered as material for these components and shaped into innovative engineered heat exchange surface. The partners foresee an initial market worth up to 180 MEuro by 2020, generating/maintaining 4000 job opportunities for skilled o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Capture-and-Release Organic Nanomaterials for Optical Sensing and Control of Cells' to be submitted under Horizon Europe.

assistant: **Abstract**

Fluorescence sensing materials enable detection of biologically active molecules at the cellular level, whereas photo-responsive materials for molecular uncaging allow controlling cellular processes. Would it be possible to merge these two research fields? The aim of CaptuRel is intelligent fluorescent nanomaterials undergoing bioinspired cycle of specific capture/sensing and photorelease of naturally present bioactive species, protons and neurotransmitters (NTs), for sensing and controlling chemical gradients at the biological interface. These CaptuRel materials will use protons and NTs as messengers to establish chemical communication with other materials and cells in a two-way detection-action regime. They will be applied for sensing and controlling activity and connections of neurons. The project is composed of three work packages. (1) We will establish concepts of fluorescent artificial receptors that exploit adaptive and dynamic covalent chemistry with fluorescent dyes and recognition ligands in nanoparticles for specific reversible capture/sensing of NTs. They will change their fluorescence color/intensity on specific capture of NTs and lose their affinity to NTs at low pH. (2) We will introduce photoacid nanomaterials capable to generate and control pH gradients at distances 0-1000 nm and apply them for short-distance chemical communication with materials and cells. (3) We will obtain CaptuRel materials capable of NT capture and photorelease by coupling artificial receptors with photoacids. They will sense and control NT gradients at 1-100 µm distances and enable us to establish principles of long-distance material-material and material-cell communication based on NTs. This high-risk/high-gain multidisciplinary project will establish a paradigm-shifting concept