RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Methodology for Effective Decision-making on Impacts and AdaptaTION (MEDIATION)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Assessment of climate change impacts, vulnerability and adaptation requires a combination of generic and context-specific knowledge. Currently, the availability of such knowledge in Europe is fragmented and incomplete. MEDIATION addresses this challenge through six activities: (i) analysis of the decision-making context; (ii) inventory, review and improvement of methods and metrics for impacts and vulnerability analysis; (iii) likewise for costing of impacts and adaptation options; (iv) development of an overarching integrated methodology; (v) development of a flexible, interactive common platform for knowledge sharing; and (vi) dissemination of this knowledge and training. The components of the project will be connected in an iterative fashion, using case studies which combine selected regional, sectoral and cross-sectoral characteristics and policy questions. The consortium combines eleven top European scientific institutions with a high reputation and long experience in impacts, vulnerability and adaptation research and assessment. They represent different regions in Europe with contrasting vulnerabilities, cover the wide array of disciplinary and interdisciplinary knowledge required to assess sectoral and cross-sectoral vulnerabilities, already participate in numerous related European and national research programmes, and have extensive expertise in science-policy interactions. The project will establish an Advisory Group of key international scientific experts and climate change policy makers to strengthen the scientific basis of the project as well as the policy relevance. In addition to scientific innovation, MEDIATION aims at supporting national and international policy development through targeted interactions, including the UNFCCC process (notably the Nairobi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Overcoming the epigenetic and therapeutic barrier of EVI1-overexpressing cancers' under Horizon 2020.

assistant: **Concept**

Deregulation of the EVI1 oncogene is a key transforming event in the development of many malignancies, most prominently very high-risk acute myeloid leukemia (AML), ovarian, colon, breast, non-small cell lung cancer, and soft-tissue sarcoma. For decades, both EVI1 function and the mechanism underlying its deregulation have been poorly understood. The consequent lack of a targeted therapy against EVI1 establishes a pressing medical need. In a recent study investigating a distinct category of EVI1-driven AML with inv(3) or t(3;3), we characterized the regulatory domain of EVI1 and identified a master regulatory element of the stemness factor GATA2 to be rearranged to EVI1, thereby deregulating both genes. Applying functional genomics and genome-editing, we found that the rearranged enhancer element adopted novel features, such as superloading of the epigenetic reader and chromatin regulator BRD4, allowing its inhibition with BET/bromodomain inhibitors with relative EVI1 specificity. Interference with EVI1-regulatory mechanisms thus has potential therapeutic value in EVI1-transformed tumors. To pave the way for epigenetic targeting of other EVI1-expressing malignancies, we aim to identify genomic enhancer sequences and protein components of the EVI1 regulatory domain by systematic epigenetic and proteomic profiling. Specifically, we seek to achieve the following experimental goals: (1) Identification of the mechanism underlying EVI1 deregulation in non-3q-rearranged AML and solid tumors; (2) Addressing the role of breakpoint-associated transpos-able retroelements; (3) Characterization of the transcription factor complex regulating EVI1; (4) Identification of epigenetic resistance mechanisms in EVI1+ AML by using an in vivo model and a genome-editing approach. The proposed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'RUNFASTER4EU- Flagship demonstRation of Bio-based valUe chaiNs For vAloriSaTion of sustAinable oil cropS for marketable applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RUNFASTER4EU will demonstrate the sustainability and replicability at industrial scale (TRL8) of a new value chain focused on the large-scale cultivation of low-ILUC-risk oil crops on marginal lands, avoiding competition with food or feed. These crops will provide vegetable oils and residual biomass for high-value bio-based products (cosmetics formulations, bio-stimulants, feed ingredients, herbicides, dielectric fluids, bioplastics, NIPU for vertical gardens) in a cascading approach. Building on previous and ongoing EU projects (FIRST2RUN, BRILIAN, MIDAS, CARINA), RUNFASTER will i) enhance bio-based value chains, prioritizing soil health and carbon sequestration, ii)  upgrade two flagship plants in Italy (Matrica - Porto Torres, Versalis - Crescentino) and iii) realize Large-scale cultivations, i.e., safflower (Carthamus tinctorius), validating innovative agronomic practices with farmer involvement. RUNFASTER partners will demonstrate downstream processing and cascading valorisation of biomass, with products tested by end-user industries to meet SSbD standards. Sustainability, circularity, and safety will be assessed via Life Cycle and Ecosystem Services methods. RUNFASTER will engage local communities, provide guidelines and training for farmers, and develop an IP-compliant exploitation strategy and business plan for replication. The approach will also be validated in Spain, Greece, Serbia, and Romania on fragile (i.e. contaminated) soils with other crops, such as cardoon and rapeseed.


**Keywords:** Low-ILUC-risk oil crops; Full biomass valorisation; Sustainable fields cultivation practices; Upgraded biorefineries and bioprocesses; Biobased building blocks; Biobased bioproducts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'WAstewater Treatment using Efficient Reactors integrated with Advanced Catalytic Technology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Oxyle’s vision is to be a global key partner in providing sustainable and efficient wastewater treatment. We have developed novel wastewater treatment reactors capable of destroying over 90% of a wide variety of toxic micropollutants from wastewater effluents, including the highly persistent compounds that are resistant to existing treatments. In contrast to existing technologies, our green approach is highly efficient, cost competitive, uses clean energy sources, and imposes a low carbon footprint. We will provide modular reactors of varying sizes to meet the cleaning requirements of various customer segments. Decentralized cleaning will be provided with our smallest reactors to industries, hospitals, and research laboratories who are interested in avoiding leakage or intermixing of hazardous wastewater. Centralized cleaning will be provided with our larger reactors to pharmaceutical and biotech companies, hospitals, and wastewater treatment plants who require larger volumes of wastewater to be treated. A patent has been filed in 2018 to protect our invention, and we have already conducted several successful on-site customer pilots using our TRL 6 small-scale prototype. With EIC accelerator pilot grant we aim to bring our small-scale reactors to market in 2023 and provide our customers with a game-changing wastewater treatment. Our manufacturing partner will produce the reactors and we will manufacture our novel catalyst. Revenue will be generated from a licensing fee and recurring catalyst sales. Our aim is to have 70 operational small-scale reactors providing efficient treatment to eight customers in 2023. In 2026 we will have 5620 operational reactors in all three cleaning sizes and serve 762 global clients to generate 139 M€ in revenue.


**Keywords:** Micropolluta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AFB1-generated cGMP targets CNGC14 to trigger rapid auxin responses in plants' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Rapid auxin responses initiate cellular changes, which are important for rapid, auxin-induced root growth inhibition and root gravitropism. Accumulating evidence shows that these rapid responses are mediated by TIR1/AFB signaling: Auxin enters the cell by influx or diffusion and activates the AFB1; within seconds, AFB1 activates a trio of tightly connected rapid responses, including PM depolarization, CNGC14-dependent cytosolic Ca2+ increase, and apoplast alkalinization, which lead to rapid root growth inhibition. However, how AFB1 mediates these rapid cellular responses via CNGC14 remains unknown.Until recently, my host lab found that TIR1/AFBs have additional Guanylate cyclase activity and that its product, cGMP, rapidly and transiently increases in roots after auxin treatment. Importantly, application of cell-permeable cGMP triggers cytosolic Ca2+ increase in a CNGC14-dependent manner and rapid root growth inhibition in Arabidopsis. These observations collectively imply a linear AFB1 - cGMP - CNGC14 - Ca2+ non-transcriptional signaling pathway, which explains well at least part of the mysterious rapid auxin responses. However, how the auxin perception product, cGMP regulates CNGC14 and orchestrates Ca2+ influx is still unclear in planta. Thus, filling this major knowledge gap is eagerly awaited and will open entirely new possibilities for a mechanism of cytosolic Ca2+ oscillation in planta.In this proposed research, I aim to test the hypothesis that AFB1-generated cGMP acts as a second messenger, targeting CNGC14 to trigger rapid auxin responses in plants. We will i) clarify the binding between cGMP and CNGC14 in vitro and in vivo; ii) test the importance of cGMP binding to CNGC14 functions in plants; iii) explore the mechanism, by which cGMP regulates CNGC14.My inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The cellular origins of Hepatocellular Carcinoma: possible role for Hedgehog pathway' (HEDGEHEP) targeting Seventh Framework.

assistant: **Abstract**

The incidence of Human Hepatocellular Carcinoma (HCC) has been constantly increasing over last decades. Owing one of the highest mortality rates among cancers the HCC is resistant to the conventional cancer treatments. Therefore new approaches to treat this disease are vitally needed. The Hedgehog (HH) pathway has been recently implicated in the pathogenesis of several human cancers including those of the gastrointestinal tract. There is evidence that the HH pathway might be important in regulating the homeostasis of the liver and its deregulation might contribute to the development of the liver cancer. In the current project the involvement of the HH pathway in the liver cancer will be investigated in more detail taking advantage of transgenic animal models. The following tasks will be fulfilled: 1. Characterization of the involvement of hedgehog signaling in regulation of liver stem/progenitor pool and liver carcionogenesis. 2. The description of expression of GPR49 in normal liver and liver cancer. The effect of deletion or overexpression of this gene in liver development. 3. Investigate the possible existence of liver cancer stem cells. Characterization of GPR49 as possible marker of liver cancer stem cells. 4. Verification of the activity of known HH inhibitors on hepatic progenitor cells and possible liver cancer stem cells.  The methodology involves monitoring the cellular composition of liver by means of flow cytometry and advanced imaging, evaluating the stem-cell and oncogenic potential of sorted cells by in vitro growth assays and in vivo transplantation experiments combined with lineage tracing using genetic markers. The gene expression signatures will be analyzed in the potential stem cell populations and based on these the pathways of interest will be stud
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DEVELOPING CRITICAL SUPPORT TOOLS FOR MULTIMEDIA PUBLISHING' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

MULTIMEDIA BROKER aims to integrate a number of multimedia tools into an infrastructure which will support publishers with new means of developing content and products, and consumers with new facilities for using these interactive products creatively and efficiently. The project is building on a feasibility study which analyzed user needs in the areas of electronic publishing, information retrieval and dissemination and will be based on existing standards. Multimedia Broker will support the development of new applications in three distinct sectors, which represent key markets for the multimedia publishing industry : training, education and consumer products. It will also address the complementary issues of human resources and organizational structure. Open to advertisers, the proposed system will enable easier cooperation between publishers and authors and help consumers to query networked products.The project follows a six month feasibility study into user requirements in the three main elements of multimedia publishing - electronic publishing, information retrieval and dissemination. Based on this research the consortium developed the Multimedia Broker concept. This is intended as both a suite of technical support tools and an architecture for an easily implemented multimedia publishing and access system. It is based on existing standards.  The proposed system provides an infrastructure for publishers to work more easily with their authors and to provide their consumers with the tools to query the networked products on offer. It incorporates tools for advertising agencies to supply ads electronically to the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Melding behavioural ecology and biomaterials research to track the evolution of mechanical super-performance of spider silk composites' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Many organisms assemble biological materials into architectures and tools that add and extend biological functions - with profound ecological effects, and inspiring human technologies. However, there is no general concept of how evolutionary bio-material innovation arises from both the physiological and the behavioural recombination of compounds. SuPerSilk aims to understand how mechanical super-performance evolves by disentangling the concerted effects of both physiological and behavioural factors on structure-function relationships, utilizing spiders and their silk products as a model system. Specifically, SuPerSilk will (1) determine if the diversification into different types of silk glands facilitated the evolvability of spider silk performance, (2) test if the behavioural combination of different spider silks into compound threads provides a fast track for the evolution of thread performance and an extension of performance limits, (3) test whether similar thread functions evolved via repeated or alternative pathways, and (4) establish a roadmap for the targeted bioprospecting of silk compounds with specific properties. Being the first project that will jointly track the evolution of base materials and their behaviourally assembled compound products, SuPerSilk will address a timely question in evolutionary biology: if and how the evolvability of physical traits can be modified by the evolution of novel behaviours and vice versa. The outcome will be a precedent for the integrative study of animal products that will establish a new line of research: evolutionary materials. In addition, by probing the structure-function relationship of behaviourally assembled silk composites, SuPerSilk will reinvigorate efforts to develop super-tough biofibres for industrial applicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Complex Synthetic Mimics of the Cell Membrane', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

I propose to bridge the gap between simple in vitro measurements of biological processes, and the complexities of the cellular environment. This requires reduced in vitro systems that are sufficiently complex to reproduce the subtleties of the in vivo biological phenomenon, but sufficiently controllable to test how quantitative changes in a particular property affects function. The challenge is to step beyond the most simple and straightforward in vitro mimics of the cell membrane, and create model systems that more closely reproduce the conditions in vivo.I propose to tackle two specific, but interrelated membrane phenomena, that are currently not captured in artificial bilayers and create new complex mimics of the cell membrane capable of tackling these systems; namely (1) protein crowding and the cytoskeleton, and (2) lateral forces and membrane curvature. Testing our synthetic mimics with models that we understand in vivo is vital. This benchmarking will ensure that the mimics we create are relevant and will help ensure the more ambitious later goals of the this proposal are successful.We will then take these tools to go on and aim to create a synthetic mimic of the bacterial membrane.However we are not limited to creating purely natural duplicates, and we can exploit a much wider range of building material than nature. In addition to creating complex mimics, we will also create totally new synthetic systems inspired by the properties of the cell membrane, but possessing unique properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Constraints for the realistic equation of state of dense matter from the dynamical evolution of compact star space-times' (DYNEOS), addressing dissemination and exploitation.

assistant: **Impact**

Earth-based experiments, the possible way to explore experimentally the regime of presently unknown equation of state of matter for densities higher than the nuclear saturation density, is to rely on the astrophysical observations.We should therefore study neutron stars in order to discover the mysteries of extremely dense matter physics, and to provide information about dynamical processes taking place in the Universe. Moreover, for present day neutron stars are the most promising sources of gravitational waves - the accurate theoretical waveforms are essential for detection.I propose to study the time evolution of neutron stars - physical processes present in binary systems at the last stage of in spiral phase, elastic properties of the crust in spinning-down pulsars, stability of non-linear modes for rapidly rotating stars, dynamical re-configuration of the star structure during phase transitions, collapse of supra-massive neutron star, as well as, in each case, direct computation of resulting gravitational wave emission.All mentioned above physical processes hopefully observed in future by neutrino, electromagnetic and gravitational wave detectors will carry a certain imprint of underlying dense matter physics. The problems will be solved analytically and numerically by means of the state-of-the-art pseudo-spectral multi-domain scientific library LORENE, developed by Paris-Meudon world-leading team of scientists.From a global point of view, the project agrees well with the collective multi-disciplinary effort carried out in Europe to consolidate the scientific community, and strengthen the collaboration with other international groups.