RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bio-molecular characterization of tumour stem cells and their use as targets of immune and pharmacological therapy' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Tumours are composed by a heterogeneous cell population and even when the majority of the tumour mass can be destroyed by therapeutic interventions, the in vivo expansion of resistant tumour cells leads to disease relapse and death of the patients.Tumour heterogeneity is the result of continuing somatic mutations and the outcome, mainly, of the aberrant differentiation of tumour stem cells (TSC), which are responsible of initiating tumour growth. Isolated tumour-initiating cells displayed biological features of stem cells, such as the ability of self-renew, ability to form non-adherent colonies when seeded at clonal density and to differentiate recapitulating the original tumour they were derived from.In cancer cells the pathways of self-renewing are deregulated contributing to oncogenesis. Tumour stem cells have been recently identified in breast carcinoma. Our aim is to determine if TSC can be specifically targeted with new therapies since stem cells are the only ones responsible for the genesis of new metastasis.Thus our research program will develop along four specific objectives:- Isolation of putative TSC from breast carcinoma;- Production and therapeutic use of monoclonal antibodies specific of TSC;- Prognostic value of TSC evaluation;- Evaluation of t he breast TSC genetic expression profile.These studies will contribute to the identification of new therapeutic approaches not based on proliferation but on biomolecular features of stem cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DNA-origami scaffolds for structure determination by single particle analysis'.

assistant: **Concept**

Single-particle analysis of electron cryo-microscopy (cryo-EM) data can now provide near-atomic resolution information for large and high-symmetry protein complexes. However, application of the same method to small proteins is problematic, mainly because low signal-to-noise ratios hamper particle selection and orientation determination.The proposed research aims to tackle this problem by binding proteins to large 3D scaffolds made of DNA origami. The main idea is to use a hollow rectangular frame (called DNA alignment frame) with a dsDNA helix (called rotation axis) spanning the interior hole of the frame. By using a specific sequence, DNA-binding proteins may be bound to the rotation axis in a specific manner. The orientation of the bound protein may then be controlled by exploiting the helical character of the rotation axis in a series of experiments where the position of the binding site on the rotation axis is varied. Thus, experimental information about the orientation of the protein may be obtained, which will be used as probabilistic priors in a statistical 3D reconstruction approach. Application of this procedure to E. coli MutS and the human Trf2/Rap1 complex will serve as proof-of-principle and may lead to better understanding of their function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Control and Optimisation for Energy Positive Neighbourhoods' to be submitted under Seventh Framework.

assistant: **Abstract**

Buildings are responsible for 40% of energy consumption and 36% of EU CO2 emissions, whilst the transportation sector is responsible for about 30% of the EU CO2 emissions. Achieving energy performance of neighbourhoods, including buildings, transportation systems and other supporting systems, is key to achieving the EU Climate & Energy objectives, namely a reduction of 20% of greenhouse gas emissions compared to 1990 levels by 2020 and a 20% energy savings in primary energy use by 2020. These challenging environmental targets can be met only by a mix of energy-saving and energy-efficiency measures, together with other relevant actions achieved through research and innovation. Improving the energy consumption and holistic performance of buildings and neighbourhood systems is a cost-effective way of fighting against climate change and improving energy security, while also creating new markets and new job opportunities, particularly in the building sector. COOPERATE will develop an open, scalable neighbourhood service and management platform that integrates local monitoring and control functions with a cloud based service platform for the delivery of innovative energy management, security and other services in order to progress towards energy positive neighbourhoods and achieving 2020 targets. COOPERATE will carry out a substantial validation of the concepts in two validation sites, the Bouygues Challenger campus and the CIT Bishopstown campus. In doing so, COOPERATE addresses the challenges of the call by developing management and control systems, and decision-support systems addressing the dynamics of energy supply and demand in neighbourhoods. COOPERATE will optimise the use of energy beyond the buildings, includes the integration of renewable energy sources and the con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent tourism and cultural information through ubiquitous services' under Sixth Framework.

assistant: **Concept**

iTACITUS aims to provide a bespoke experience for the individual cultural traveller, based upon a dispersed repository of cultural (e.g. historical, scientific and archaeological) resources, enabling both location-based and context-based interface paired with location-independent services. The services provided will include audio-visual, mixed reality and VR organisational components, and will be delivered in a flexible and timely fashion. The system is based on an advanced user interface on mobile devices supporting image recognition voice interface and the capability of using any available hardware interface: WiFi, Bluetooth, UMTS/GPRS and even infrared interfacing. iTACITUS will provide a virtual context supporting knowledge conceptualization, thus making the available cultural resources reusable and integrable into new conceptual contexts. With such instrumentation a user is able to locate, without a direct access to search engines, and to find information that is likely to be useful in his present cultural context especially where mobility is fundamental.iTACITUS suggests an active approach to cultural heritage narrowing the gap existing between an expert researcher in the cultural field and a highly cultured and informed visitor, suggesting an active approach for integrating own real-time experience in cultural and scientific heritage by reusing available complex digital material to provide and integrate, into an existing framework, additional (and often complex) new information.The objectives of iTACITUS are two-fold:1. iTACITUS will investigate new methods of representing cultural heritage virtually (but integrated into existing realities).2. iTACITUS will allow the customisation of personalised walking and public transport tours in urban areas, archaeological s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative tool for personalized treatment of patients with neovascular age-macular degeneration: dosage optimization for long term efficacy treatment' (EyeTREAT).

assistant: **Concept**

With the ageing population, visual threatening illnesses are increasing. For instance, age-related macular degeneration (AMD) is expected to affect almost 25 million Europeans by 2040. The AMD treatment consists in regular injections of the anti-VEGF therapeutic drug (Lucentis, Avastin, Eylea) into the eye ball, vitreous, for the rest of the patient life. However, the dosing intervals varies widely among the patients and there is no a clear consensus or quantitative method for evaluating the injection frequency. For that, computational tools linking the drug dose regimen and the drug effect in the retina are needed. However, such pharmacokinetic-pharmacodynamic models are still missing. Combining population pharmacokinetic and optical coherence tomography (OCT) imaging technique is a new, novel and promising approach. The drug effect can be evaluated non-invasively, measuring the central macular thickness in the retina scan. The models generated will allow appropriate individualized dosing regimen to the patients in clinics that will be anticipated from individual retina scan determinations with OCT. The optimization and personalization of dosing regimen will ensure an efficient long-lasting treatment, improving patient quality of life while reducing the burden to the health care system. Moreover, the models will increase our understanding in the treatments, constitute a pioneer tool in effect assessment in ocular therapeutic field and a first step towards more advanced ophthalmic models. The candidate has strong expertise in intravitreal pharmacokinetic and this project will advance her into clinical pharmacodynamic modelling at the renowned Centre for Applied Pharmacokinetic Research, University of Manchester. The inter-disciplinary and inter-sectoral character of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unmasking insulin resistance triggering mechanisms using microphysiological two-organ systems as in vitro disease models of metabolic syndrome and non-alcoholic fatty liver disease' to be submitted under Horizon 2020.

assistant: **Abstract**

Insulin resistance is one of the key factors for non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome development and progression. Both diseases have an immense societal and economic impact. However, the biological mechanisms triggering the onset of the diseases are still poorly understood. NAFLD is assumed to be triggered by hepatic insulin resistance, possibly resulting from adipose tissue lipolysis dysregulation. The study of the crosstalk between liver and adipose tissue is thus essential for the understanding of insulin resistance triggering events but is limited by the availability of suitable models. Hence, the aim of this proposal is to establish a two-organ-on-a-chip-model and to utilize it to study liver-adipose tissue crosstalk and understand how hepatic and adipocyte insulin resistance develop and influence each other. In order to study the molecular mechanisms of inter-tissue communication and overcome the complexity and non-human nature of animal models, an innovative organ-on-a-chip system using a flexible connection technology will be utilized to culture hepatocytes and adipocytes in connected systems. Human stem cell derived adipocyte- and hepatocytes-like cells with the same genetic background will be cultured in this system and characterized regarding their metabolic competence. The cell’s functional characterization, transcriptomic and metabolomic analysis, upon pharmacological induction of insulin resistance, will allow to unravel its molecular triggering mechanisms in vitro. The same approach will be applied to patient-specific cells creating a patient-specific physiopatological in vitro model under distinct nutrient mixtures. This project is a highly innovative multidisciplinary approach that uses organ-on-a-chip technology for in vitr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research and Training Network for Smart and Green Energy Systems and Business Models' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

“Collaborative Smart Grids” (CSGs) are a promising concept built on digital technologies and economic and organizational structures, directly linked to the empowerment of consumers, the promotion of behavioural change and increased collaboration among all stakeholders. CSGs require a new vision but also innovative business models and technology developments around energy production, distribution and consumption to be successful and sustainable. The multidisciplinary and multilayer concept embedded in CSGs is essential to contribute to greener and smarter energy systems in our societies. SMARTGYsum - SMART Green energY Systems and bUsiness Models- will train 15 ESR for 36 months to enable the implementation of the Smart Energy vision, focusing on different technical and socioeconomic aspects that conform Electric Energy Systems (EESs)  and CSGs, providing an excellent basis to develop their future careers in Power Electronics, Electric Engineering, Material Sciences, ICT, Data Sciences but also energy capturing of value, value chains, finance & investments, management of energy markets, economical and policy instruments, etc. As a result, there will be a network of academic and industrial partners closely collaborating following a transferable, inter and multidisciplinary approach, aimed at raising the employability and career opportunities of ESRs within the public and the private sectors, as well as their potential for conducting innovation, entrepreneurship and for impacting in the European society at medium and long-term.


**Keywords:** Green Energy, Green Economy, Sustainable development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Comparative evaluations of innovative solutions in European fisheries management' (CEVIS).

assistant: **Innovation**

CEVIS assesses potential innovations for European fisheries management regimes in respect to four general management objectives: biological robustness; economic efficiency; the cost effectiveness of management activities; and socia robustness. CEVIS examines four types of regime-level innovations: the use of participatory approaches to fisheries governance; rights-based regimes; effort-control regimes and decision-rule systems. The central research objectives of CEVIS are expressed by four disciplinary, cross-case work packages that focus on the implications of these types of innovations for the general management objectives in four case studies in the EU and the Faroe Islands. Before these case studies begin the research will take a close look at cases of innovative fisheries management in other developed countries. Visits will be made to four places outside the EU that have similar fisheries and have implemented these four types of innovations. CEVIS has two final products. The first is an Innovation Evaluation Framework made up of indicators of inputs and outcomes in relation to the four general management objectives. This will be an aid to fisheries managers wishing to assess the suitability of possible changes in EU fisheries management practice. The second is a report based on the case studies that evaluates this specific set of potential regime-level innovations for use in EU fisheries management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DIgital LAser PROduction: Digital Twins of Laser Processing for Multi-Capability Manufacturing of Complex Components and Certification' (DILAPRO) targeting Horizon Europe.

assistant: **Abstract**

Making Europe the first digitally led circular, climate-neutral and sustainable economy needs major changes across manufacturing: efficiencies in energy and material consumption, new solutions to problems in certification and standardisation, and upskilling of the European workforce. DILAPRO contributes to all of these, driving decarbonisation and the twin Green and Digital Transitions via two ground-breaking software tools for laser-based production of complex products. DILAFACT (Digital Laser Factory) is a sustainable and scalable platform for laser process planning via Digital Twins of laser-material interactions, including additive, subtractive, and thermal processes. DILACERT (Digital Laser Certification) tackles a major hurdle in rapidly-developing laser and additive manufacturing technologies: certification and standardisation. In the short DILACERT enables end users to easily process production data for certification; in the long term it paves the way for remote semiautomated digital certification of produced parts, a major paradigm shift in complex part production. DILAPRO grounds its development in specific materials (316L, IN718, IN625) and laser technologies (PBF-LB, DED-LB, and Laser Texturing) as deployed on 6 operational production lines owned by project partners. These will be developed as distinct modules during the first half of the project, and synthesised into DILAFACT and DILACERT in the project’s second half. To ensure the competitiveness and sustainability of European manufacturing in the long term, other developers and end-users will be able to contribute modules to both software, kick-started by DILAPRO’s living communities and innovative IP plan covering both commercial and OA licenses. DILAPRO offers two scalable, sustainability-focused soluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Research and Innovation Network for Europe and Africa'.

assistant: **Innovation**

In response to the present objectives of the EU-Africa partnership in science, technology and innovation, and addressing the STI priorities of the 2014 EU-Africa Summit, RINEA addresses three specific and complementary objectives by a range of targeted activities:1. Strengthening the quality and quantity of partnerships between research and innovation actors in EU Member states, in Associated Countries and in countries in Africa through networking events between research and business communities, through proposing the elimination of cooperation obstacles and optimising framework conditions and through raising awareness and disseminate information of cooperation opportunities for research and innovation partnerships offered by H2020 and by other major programmes in Europe and Africa.2. Encouraging transnational coordination of programmes and policies for international cooperation in STI for greater coherence, joint ownership and resource efficiency, through advancing the model established by ERAfrica for jointly owned EU-Africa funding instruments for STI cooperation and through facilitating the launch and the management of calls for proposals around topics of mutual concern and relevance to the EU-Africa bi-regional partnership. 3. Supporting and enriching formal and informal processes of bi-regional STI policy dialogue between the EU and Africa through building wider understanding of the objectives and outcomes of formal bi-regional policy dialogue, through contributing to the evidence base for policy and decision making, including strategic priority setting, by the recognised governance structures of the EU-Africa STI partnership, e.g. HLPD, through supporting the implementation of outcomes of formal policy dialogue and through fostering exchange between formal and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Magnetic integrated circuits for industrial switch and sensor applications' to be submitted under Fourth Framework.

assistant: **Abstract**

The work is centred around four demonstrators:- Magnetic microswitch based on magnetic integrated circuits for automotive applications, to be exploited mainly by SAIA. The need to introduce a new technology for low current applications is dictated by SAIA's customers in view of potential Far Eastern and North American competition. - Programmable rotary switch based on integrated magnetic sensors for consumer applications, to be exploited mainly by Seuffer. By mid 1996, a demand for engineering samples of electronic switchboards is anticipated, in order to replace the present electromechanical products. - Current monitor based on integrated magnetic sensors for high-voltage power supplies and commercial vehicles, to be exploited mainly by CAEN and Seuffer. - Three-dimensional magnetic badge to record exposure to magnetic fields based on integrated magnetic vector sensors, to be exploited primarily by CAEN. The targeted high-end product might be favoured by legislation in the medium term.The goal of the project is to deliver packaged and tested evaluation samples of several specific CMOS integrated magnetic microsystems for a variety of attractive high volume applications as well as high-end safety products. The main objective is to elaborate, consolidate and to transfer to the industrial environment the know-how for mass production of versatile integrated microsystems based on magnetic sensors. The common ground is the design and test of CMOS based magnetic sensor and interface circuit prototypes by ETH Zürich and the University of Pavia, and their manufacturing by AMS.