RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The development of vectors for genetic manipulation and gene discovery in mammalian systems'.

assistant: **Innovation**

Transposons are important tools in genetics and molecular biology. They are widely used in academic and industrial settings where technical innovations continually expand the range of applications. Transposons are promising tools in synthetic biology and gene therapy applications. The amount of DNA a transposon can carry is in principal unlimited. However, in practice, when transposon length is increased, for example by the addition of a therapeutic transgene, its ability to transpose is reduced. This phenomenon is known as 'length dependence' and limits the efficiency of transposons in gene delivery applications.Although length-dependence is a well documented phenomenon, the causes have not been investigated and remain unclear. We believe that the first step in combating the problem is to understand the underlying causes. We have therefore designed biochemical and genetic assays that will reveal the stage(s) of the transposition reaction at which length-dependence operates. The assays will be used to test those transposons that are currently under the most intensive development as tools in eukaryotic systems.Some of these transposons are reported to be substantially free of length-dependence. Our assays will confirm if this is true, and if so whether this 'immunity' is a property of the respective transposases, of the DNA sequences, or due to the binding of host proteins.One of the attractive features of transposons as gene delivery vectors is that there are a lot to choose from, and different elements will have different advantages and disadvantages with different transgenes in different applications. If we can identify the causes of length-dependence in some elements, and the mechanisms by which it is minimized in others, we may be able to combine the most advantageo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extracellular Vesicles as mediators of Pre-Metastatic Niche Formation in Melanoma' (METMAP) targeting Horizon Europe.

assistant: **Abstract**

Every 2 minutes someone in the world is diagnosed with melanoma, so by the time you read this application dozens of new melanoma cases will be detected. Beyond its growing incidence, cutaneous melanoma is the most aggressive type of skin cancer and notorious for its high metastatic propensity, which constitutes the primary cause of death for these patients. Cellular heterogeneity and plasticity are key features of melanoma, supporting disease progression. The host laboratory has recently charted a functional map of the melanoma ecosystem and identified a cell population that fuels tumor growth (pre-EMT) and another that functions as metastasis-initiating cells (MICs). Increasing evidence indicates that metastatic dissemination of MICs relies on the formation of favourable microenvironments, or pre-metastatic niches (PMN), at secondary sites, and that extracellular vesicles (EVs) shed by the primary tumour are key mediators of PMN formation. I hypothesize that EVs produced by phenotypically distinct melanoma cells are likely to contain different biological information, and thus may exert different (possibly diverging) roles in PMNs formation. In METMAP, I will (i) determine the melanoma cell state(s) contributing to the formation of PMNs via EVs; (ii) dissect the molecular mechanisms underlying PMN formation; and (iii) unravel how these mechanisms facilitate metastatic spreading. I will leverage my background in EVs biology and establish melanoma cell state-reporters to track EV-mediated communication between melanoma subpopulations and PMNs. Proximity labelling will be used to dissect the bioactive contents of EVs transferred to PMNs and perturbation experiments will be conducted to decipher this complex interplay. Through METMAP, I will deliver a functional understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'High efficient Particulate free Gasoline Engines'.

assistant: **Objectives**

The UPGRADE project aims to support the transition to a high efficient, cleaner and affordable powertrain technology systems, based on Spark Ignited GDI (Gasoline Direct Injection) approach, suitable for future Light Duty applications. The project also includes a deep analysis of the phenomenon of the formation of the nanoparticles in relationship to the engine design and its operating conditions and,  with regard to the after-treatment solutions, the study and development of new Gasoline Particulate Filter (GPF) technologies.To increase the engine efficiency under Real Driving conditions, the following steps will be carried out:- address stoichiometric combustion approach on the “small” size engine and lean-burn combustion approach on the “medium” size one- study and develop the best combinations of technologies, including advanced VVA/VVT capabilities, advanced boosting system (including electrically assisted booster operations), EGR (Exhaust Gas Recirculation) and thermal management systems- Explore and implement advanced fuel injection (direct) and ignition system supported by new dedicated control strategies that will be integrated in the ECU (Engine Control Unit) software. In order to demonstrate the call overall targets (15% improvement on CO2 emissions based on the WLTP cycle and compliancy with post Euro 6 RDE standards) the project will see the realization of two full demonstrator vehicles: one B-segment vehicle, equipped with the small downsized stoichiometric engine, and one D/E vehicle equipped with the medium size lean-burn engine. The vehicle will be fully calibrated and assessed by independent testing, according to on road test procedures, using the available best representative PEMS (Portable Emission Measurement System) technology and considering also
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced robotics technology for efficient port production' in the context of a Fourth Framework call.

assistant: **Objectives**

The proposed demonstrator project will utilise the complementary state-of-the-art research know-how within the consortium to implement the first European production system using food grade robotics equipment designed to end-user specification. The proposal is directly relevant to the expectations of the CEC Agriculture and Fisheries programme under section 3.3.2 Advanced Technologies, dealing with robotics and automation for cutting and handling biological products such as meat. The meat industry has reached a saturation point both in Europe and in the OECD countries, following a growth in meat consumption in the 1980s. As a consequence of the Uruguay round of GATT, the European meat industry is facing increased competition from outside the European Union, especially from the U.S., South America and New Zealand. Increased competition means companies have to improve the price and quality of their products at high levels of throughput. In manual production systems workers, who process several hundred carcasses an hour, will tire and lose concentration, leading to loss of cut accuracy and quality. Abattoirs are incurring higher production costs as they have to comply with the high levels of hygiene specified in European Council directive 91/497/EC. The industry has to contend with a shortage of labour as the available work force decreases. It also suffers from a high turnover of staff (increasing training costs) and high injury rates. The development of a research system under a previous EC funded project has been a key breakthrough for the industry, however, the use of the methods and technologies generated by the research to date have yet to be demonstrated under production conditions. This is intended by this proposal as a first demonstration project. In addition to Tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Angström laboratory - nanomaterials and nanotechnologies' in the context of a Fifth Framework call.

assistant: **Objectives**

Materials Analysis Laboratory:This lab includes high resolution transmission electron microscope, environmental and other types of scanning electron microscopes, and sample preparation laboratory for specimen preparation. Process Laboratory. This lab is situated in a cleanroom environment including:1) diffusion, oxidation and ion implantation;2) lithography and mask fabrication;3) thin film deposition;4) dry etching and;5) wet chemistry facilities.Nanoparticle Equipment: The machine allows preparation of metal and metal-oxide crystalline nanoparticles (nanocrystals) in the size-range of several nm - several 10 nm and nanoparticle films. CVD (Chemical Vapor Deposition) and ALD (Atomic Layer Deposition) Laboratory. Thin films of metals, metal-oxides, BN, GaN/AlN can be deposited in this laboratory by the above-mentioned methods.Magnetic Properties Laboratory: The instrumentation involves several SQUID magnetometers, a flux noise SQUID setup, a LakeShore ac susceptometer, a vibrating sample magnetometer, and a scanning probe microscope system that can be used in both AFM and MFM (magnetic force) modes.Optical Spectroscopy Laboratory:Several optical spectrophotometers are available in the wavelength range of 300 nm - 50 micrometer to measure transmittance and reflectance of samples. X-ray Diffraction Laboratory High precision diffractometers are available to use. MicroRaman SpectrometerA Renishaw 2000 system Micro-Raman spectrometer is accessible to operate.Application:Potential users are requested to fill in a simple application form, including describing their proposed projects. Detailed information can be obtained:http://www.angstrom.uu.se/nanocentre/.Project Manager:Dr. Gunnar Holmgren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovation Denmark 2015-2016' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Danish EEN will provide skilled personnel to provide two services:Key Account Management Services to SMEs in the SME Instrument and Enhancing Innovation Management Capacity building services to potential high growth SMEs. A total of minimum 80 service packages will be implemented.Two tools will be used to carry out these tasks - Growth Wheel for the KAM role, to provide a brief and simple feedback onthe company's management ability and IMP3rove for all EIMC cases, to provide a thorough picture of the innovationmanagement capacity of the SMEs.Companies in the EIMC work will be integrated with the wider Danish and European innovation support eco-system.


**Keywords:** Innovation Management Capacity Building, SME Instrument, Key Account Management, IMP3rove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Muslims condemning violent extremism - An interdisciplinary analysis of public initiatives in the Netherlands and Norway 2001-2015' (MUSLIM-NLNO) targeting Horizon 2020.

assistant: **Abstract**

The project comprehends an interdisciplinary study on the dilemma faced by Muslims whether or not to explicitly disavow violent extremism. It explores how Muslim organisations and youth groups in the Netherlands and Norway have responded to calls to publicly condemn violent extremism. Special attention is paid to how young Muslim women and men have used specific strategies to gain media coverage, and the gendered aspects of these strategies. The project aims to analyse recent historical developments in the two countries in theoretical and empirical depth, by studying public debates and specific public initiatives undertaken by Muslims in the aftermath of the 9/11 attacks in 2001, the murder of Theo van Gogh in the Netherlands in 2004, and the 22/7 attacks by Anders Behring Breivik in Norway in 2011. It combines a comparative historical approach with theory and methodology of religious-, media-, cultural- and gender studies. The project fills an important gap in the growing body of research on Muslims in Europe: a lot of scholarly attention is paid to public discourses that stigmatise Muslims, but far less on how people with a Muslim background confirm or subvert dominant images in their interactions with the media. Scholars have described the pressure that young Muslims perceive to explicitly disavow terrorism, but a thorough analysis of their responses has yet to be made. The project will contribute to the understanding of the mechanisms of social cohesion in contemporary European society at a time of growing global threats. Hosting arrangements at the Department of Philosophy and Religious Studies at Utrecht University guarantee excellent training and research facilities. The vibrant interdisciplinary research network at the Department and the intense supervision by t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanocarriers Optimization for Periocular Drug Delivery to the Retina' to be submitted under Horizon Europe.

assistant: **Abstract**

The incidence of chronic vision-impairing retinal diseases is increasing due to population ageing. Monthly intraocular injections are the standard of care, despite the important risks (e.g., infection and haemorrhage) associated with this practice. A promising alternative is the periocular injection of nanocarriers, which are able to enhance the permeability across the ocular membranes. However, as periocular administration relies on the drug transport mechanisms in the tissues to reach the target, animal tests are generally needed for a prediction of drug distribution after the injection.The researcher aims at the development of an ex vivo model of a whole porcine eye which will constitute an evaluation tool for periocular nanoformulations targeting the retina and will allow for a deep understanding of the ocular penetration paths. The project will (i) provide a safer alternative to intraocular injections, (ii) reduce the need for animal testing in the pre-clinical phase of product development and (iii) overcome the current limitations of mathematical models, which are generally unable to predict the complexity of nanoformulations transport. This MSCA will be implemented throughout 24 months at the University of Parma, and it will include two 3-months secondments: the researcher will be trained on pharmacokinetics mathematical models at the University of Navarra and on Organs-on-a-Chip models at Tel Aviv University. The selected methodology allows for a cutting-edge approach to nanoparticles design, promoting the synergistic use of chemistry tools (spectroscopy) with medicine and biology (ex vivo models, 3D imaging, cellular assays) and engineering tools (mathematical models, Organs-on-a-Chip).The competencies acquired during the project will complement the researcher’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design of Advanced Antenna and Multi-Sensor Hybrid Receiver for Machine Control in Harsh Environment' to be submitted under Seventh Framework.

assistant: **Abstract**

Machine Control is the largest segment of the global high precision (better than 1m RMS) GNSS market. Machine Control applications range from Precision Agriculture to Land and Offshore Construction, relying on GNSS due to its global availability and easiness to deploy and operate. Current GNSS-only technology, although successful suffers fundamental limitations that make it fit only for application in rather benign, open-sky environment. Overcoming these limitations is mandatory to extend the addressable market to application in harsher environment such as forestry, open-mining. ADVANSYS will address this challenge leveraging multi-antenna beamforming technology and multi-sensor fusion in the development of the prototype of an affordable and manufacturable high-sensitivity high-resilience Hybrid receiver concept comprising antenna, GNSS receiver and dead-reckoning sensors.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Zero damage Ultra-Low-K etch using the precursor CONDensation technique' under Horizon 2020.

assistant: **Concept**

Since the beginning of the electronic evolution, size of transistor never stops to decrease accordingly to Moore’s law. This scaling applies also to the interconnects, composed by conductor and insulating materials, leading to an overall increase of the resistivity of the conductor and the dielectric’s capacitance, ultimately causing delayed signal transmission (so-called RC delay). In order to decrease the resistivity, Al was replaced by Cu as a conductor.  The circuit’s capacitance can be lowered by using materials with lower dielectric permittivity, named low-k’s. Nowadays, the most successful low-k dielectrics are porous organo-silicate glasses, with porosity up to 50%, pore size around 1.5-2 nm and k-values down to 1.8 (k=4.2 for bulk SiO2). Interconnects are nowadays built by the Damascene technique, where the dielectric is first deposited, then locally etched away, followed by metal deposition in the patterned structure and polishing for metal excess removal. Due to their intrinsic porosity, most of processing steps cause low-k damage, amongst which plasma etching is the most damaging. The present proposal aims at understanding and optimizing zero-damage cryogenic etching of low-k materials, compatible with the micro-electronics industry (at temperature above -60°C). Besides the improvement of the etching process and the better understanding of reactions damaging the low-k materials during plasma etching, this work will investigate the phenomenon of micro-capillary condensation into porous materials, which is not widely explored and can lead to other applications in micro-electronics and in other nanotechnology domains. This research project will contribute to enable the so-called 5nm node in future CMOS manufacturing, and as a consequence it will have a wide eco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling addiction: How closely do genetic, neurochemical, electrophysiological, and behavioral experimental models predict human patterns of abuse and dependence?' (1998-2002).

assistant: **Concept**

The Neurochemistry Winter Conferences are designed to provide high-standard scientific conferences combined with advanced training for young researchers, with a specific focus each year. In the field of drug abuse research, the last decade has seen the highly profitable cooperation between gene targeting, neuroimaging, and more traditional neurochemical / neuroanatomical /electrophysiological approaches on one side and behavioral experiments on the other side, leading to important advances in the understanding how different neuronal systems contribute to the reinforcing effect and the abuse liability of addictive drugs. However, a number of issues are still unresolved. The workshop proposes to bring together experts from all cutting-edge experimental approaches to drug abuse and dependence to discuss the benefits and shortcomings of each experimental paradigms in the expectancy of cross-fertilization. Most drug abuse research has been conducted in the U.S.A., resulting in a focus on drugs that are more prevalent there. Consequently, a number of drugs of abuse that constitute more of an European problem", such as MDMA ("Ecstasy"), have been under-researched.The European-added value of the topic and for the participants consists on it focus on European research efforts and drugs of abuse that are prevalent in Europe (without neglecting the contribution of the scientific community in the U.S.A.), thus giving credence to and foster the future development of a stronger European drug abuse research task force. The disciplines represented by the invited keynote lectures are gene targeting, neuroimaging, neuranatomy, neurochemistry, electrophysiology, behavioral research in animals and humans, and clinical research. The programme will be supplemented by contributions of young s