RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Plasma propulsion with electronegative gases' to be submitted under Sixth Framework.

assistant: **Abstract**

Deep space exploration, with human interplanetary missions and robotic missions to neighbouring solar systems, are not possible with today's technology. Much effort is put into developing thrusters that use less fuel, are safer and go faster than those currently used on space missions.The proposed research project aims to revolutionize deep space exploration by developing a prototype of plasma thrusters based on a new concept recently patented by the host institution (LPTP, Laboratoire de Physique et Technologie des Plasmas, Ecole Polytechnique).The concept is called PEGASES, for Plasma Propulsion with Electronegative GASES. The prototype will use both the negative and the positive ions as propellant and will therefore potentially be both more fuel efficient and more reliable than today's electrical propulsion systems.The fellow will play a significant role in the PEGASES project by carrying out the preliminary plasma physics experiments and develop a profound understanding of the fundamental phenomena involved. She will supervise PhD students and manage a large research team towards a frontier technology development and test at the European Space Agency.The project will give the fellow the solid foundation on which to build an independent research career in the academic world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hyperspectral imaging IED and explosives reconnaissance system' (HYPERION).

assistant: **Concept**

The objective with the HYPERION project is to develop and test a system concept for the on-site forensic analysis of an explosion. The forensic tools and procedures used will in majority be at safe stand-off detection distances. This will also include tools for identification of unexploded IEDs. The on-site data provided by the HYPERION system will be the type and amount of explosive used in the attack, the point of origin of the detonation and an assessment of the type of IED. The crime scene will be mapped using 3D-registration and in the map the positions that have been analysed in detail will be marked. The forensic tools and data will be of a quality that can be used as evidence in a court of law. The quality assured data will be on-site electronically documented and sent to the police instantaneously at the crime scene.At a crime scene, due to the detonation of an IED, police, ambulance, fire brigade and the crime scene unit are parties that must be present.The first measures taken at a crime scene due to a detonation of an IED are the initiation of rescue actions. In parallel to the rescue actions the HYPERION system can be used. This includes the collection of forensic data and risk assessment of suspected unexploded IEDs using stand-off detection of the post-blast scene.After the rescue operations, all of the forensic tools of HYPERION can be used in order to investigate the type and amount of explosive used in the attack. In combination with the 3D registration of the crime scene a reverse-event analysis can be performed giving the size of the charge and point of origin for the detonation.After the crime scene area has been secured, the laboratory forensic sampling and analysis can be started. New and validated sampling protocols will be developed. The crime s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A modular micro nuclear magnetic resonance in vivo platform for the nematode Caenorhabditis elegans' (NMCEL) under Seventh Framework.

assistant: **Objectives**

Using state-of-the-art microsystems simulation, design and micro-engineering, the NMCEL project will result in a highly integrated and modular and low cost platform that is a high throughput micro-fluidic lab-on-a-chip and a sophisticated nuclear magnetic resonance (NMR) detector in one package, suitable for use in a wide-bore commercial NMR magnet. This unique platform targets the controlled in vivo NMR spectroscopy and imaging of the model organism C. elegans, for this purpose the high throughput micro-fluidic lab-on-a-chip has the necessary infrastructure to feed, hold, move and immobilise a large population of C. elegans on demand and over its lifecycle and lifetime, with operations synchronised with the remaining functions of the platform. In turn, the co-integrated NMR detector is specially adapted to the range of shapes of the nematode, and its motility, and is optimised with regard to NMR signal-to-noise ratio and spectral resolution. In order to attain high resolution, the NMR system is optimised for strong magnetic fields, through the computed layout of devices, the adaptation of microstructurable materials, and the design of electronics and control circuits. The targeted user of the platform is a C. elegans micro-biologist with a requirement to detect or discover small molecule (< 1000 Da) metabolites in vivo. High throughput in vivo metabolomic mapping, with a platform that generates molecular data on an individual-by-individual basis for populations of thousands of individuals, has the potential to open up a completely new window of research in systems biology. The NMCEL project aims to address this important step ahead.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Promoting Sustainable Freight Transport in Urban Contexts: Policy and Decision-Making Approaches' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Within a context of growing urban population, advances in urban logistics operations and improved local authority planning, especially in the field of the urban freight transport, can alleviate the associated negative environmental and economic impacts occurring in cities.Several types of stakeholders are involved in such urban logistics management processes. Among them, freight carriers and shippers are interested in minimizing freight logistics costs in order to maximize their profits, while maintaining a competitive level of service to their customers. City administrators and residents are oriented towards a decrease in traffic congestion, social costs and environmental nuisances, even though they are often direct beneficiaries of high quality delivery services. This leads to a multitude of differing and possibly conflicting objectives that are involved in urban freight transport planning and decision making, yielding a high level of complexity. This provides a main motivation for the development of tools for helping decision makers to reach higher grades of efficiency. Despite growing academic interest, the extent to which freight transport is acknowledged and formally considered in local authority transport planning varies considerably from country to country, and on a more local level, between towns and cities. As a result, policy development with respect to urban freight and city logistics is characterised by a rather fragmented approach, with many city authorities finding it difficult to address the complex set of differing views of a large variety of stakeholders. The proposed project will be aimed at identifying local authority planning needs with regards to urban/city logistics activities and the necessary pre-requisites for inclusion of stakeholders in the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Between Two Brains: Brain oscillatory basis of human collaboration' (BetweenTwoBrains), addressing dissemination and exploitation.

assistant: **Impact**

BetweenTwoBrains aims to investigate the oscillatory brain mechanisms underlying a fundamental human social behavior: collaboration. A growing dichotomy in the current understanding of this important behavior motivates this goal - Whereas there is an increasing number of empirical observations that interpersonal neural synchronization supports collaboration, the challenge is to understand the mechanism and function of this synchronization in the context of human social behavior. BetweenTwoBrains tackles this challenge in three steps. 1st Relate collaborative behavior to specific brain oscillatory networks (using dual-magnetoencephalography, dual-MEG). 2nd Test the hypothesis that there is a causal link between interpersonal neural synchrony and teamwork success (using dual transcranial alternating current stimulation, dual-tACS). Finally, 3rd, translate this research to understand the oscillatory basis of collaboration deficits in individuals with Autism Spectrum Disorder (ASD). Beyond basic research, this project will yield impact in a wide range of industries relying on teamwork (e.g., ER medical teams), and in potential new treatments for ASD. Excellent training in cognitive neuroscience research will be provided by leading experts at the University of Birmingham, UK (tACS and M/EEG) and the Aalto University, Finland (dual-MEG). After six years of research experience in experimental psychology at North American universities, the neuroscience training and reintegration opportunities provided by this fellowship will help me become an independent scientist in the European research panorama.


**Keywords:** social cognition, collaboration, brain oscillations, autism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards organic semiconductor devices design and synthesis of polymerbased field effect transistors and light emitting diodes' under Fourth Framework.

assistant: **Concept**

The exciting field of polymer-based electroactive materials transverses the traditional barriers between chemistry, materials science and solid state physics. Organic materials may replace silicon in semiconductor devices such as Field Effect Transistors (FETs) and Light Emitting Diodes (LEDs). Recent efforts have led to conjugated polymers that are solution and melt-processible and hence may be readily spread over a wide area. Low charge mobilities, however, have hampered potential solid- state applications. Poly (alkylthiophenes) have shown promise in these applications and the our objective is to improve the effective intermolecular and intramolecular Pi conjugation by stretch alignment and sidechain modification. Incorporation of mesogenic sidechains will allow orientation in the presence of an electric or magnetic field. Molecular recognition elements should improve polymer strand ordering and lead to improved charge transport properties. The novel electronic and optical properties of these materials will be studied in active collaboration with industrial partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Second generation transgenic models for human diseases: inserting gain and loss of function mutations in the mouse genome'.

assistant: **Innovation**

Genetically modified mice are of considerable value for understanding the molecular basis of human disease and for the development of new diagnostic and therapeutic approaches. In this project we propose to construct transgenic mice which will serve as mode/e for tumourigenesis, or for human developmental disorders. First generation transgenics did not mimic a natural" mutational event, because of the effect of random integration of the transgene, the use of heterologous promoters, and the presence of two non-mutated endogenous alleles. Similarly, first generation knock-outs were mostly aimed at obtaining a complete loss of function of the targeted gene, often resulting in non-informative early lethal phenotypes. The approach described in this project is a substantial step forward with respect to the above techniques, since it is aimed at obtaining mice bearing the exact replicas of naturally occurring genetic lesions in man. We will activate (or partially inactivate) genes by introducing point mutations in the targeted sequence by homologous recombination, without perturbing the endogenous pattern of expression. The targets will be four receptor tyrosine kineses (RTKs) known for their oncogenic potential, and for being involved in development Met, Ret, PDGFR, and Trk. The introduction of gain of function mutations in receptor genes should induce the appearance of a variety of tumors in the transgenic animals (oncomice). Such oncomice will be, first of all, of diagnostic va/ue, since the development of tumors in specific tissues will pinpoint the cell types susceptible to oncogenic transformation for each receptor. Furthermore, they will make it possible to explore in-vivo the multi-step nature of tumourigenesis, for example by testing the effect of the mutation in diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Anionic PhosPhoLipids in plant receptor kinase signaling' (APPL).

assistant: **Innovation**

In plants, receptor kinases form the largest family of plasma membrane (PM) receptors and they are involved in virtually all aspects of the plant life, including development, immunity and reproduction. In animals, key molecules that orchestrate the recruitment of signaling proteins to membranes are anionic phospholipids (e.g. phosphatidylinositol phosphate or PIPs). Besides, recent reports in animal and yeast cells suggest the existence of PM nanodomains that are independent of cholesterol and lipid phase and rely on anionic phospholipids as well as electrostatic protein/lipid interactions. Strikingly, we know very little on the role of anionic phospholipids in plant signaling. However, our preliminary data suggest that BKI1, an inhibitory protein of the steroid receptor kinase BRI1, interacts with various PIPs in vitro and is likely targeted to the PM by electrostatic interactions with these anionic lipids. These results open the possibility that BRI1, but also other receptor kinases, might be regulated by anionic phospholipids in plants. Here, we propose to analyze the function of anionic phospholipids in BRI1 signaling, using the root epidermis as a model system. First, we will ask what are the lipids that control membrane surface charge in this tissue and recruit BR-signaling component to the PM. Second, we will probe the presence of PIP-enriched nanodomains at the plant PM using super-resolution microscopy techniques and investigate the roles of these domains in BRI1 signaling. Finally, we will analyze the function of the BKI1-related plant-specific family of anionic phospholipid effectors in plant development. In summary, using a transversal approach ranging from in vitro studies to in vivo validation and whole organism physiology, this work will unravel the inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Healthcare applications of Stimuli-Responsive Elastin-Like Polypeptide Nanocarriers' (HsrELPnano), addressing dissemination and exploitation.

assistant: **Impact**

One of the main challenges in drug delivery is the fabrication of carriers that possess a molecular trigger or property that induces tumor cell death or activates the release of the drug cargo from the vehicle once it has reached the desired place of action. Elastin like polypeptides (ELPs) are genetically engineered protein polymers with a reversible ability to from nanoparticles by phase separation when they are above its transition temperature (Tt), while below Tt they remain solubilized. My proposal aims to study a cutting-edge finding about a recently discovered thermal pathway-dependent assembly of ELPs and translate it into innovative solutions in drug delivery. This unique feature allows protein payloads to partake in the co-assembly itself making possible to encapsulate and protect the macromolecular cargoes in the nanoparticle interior. Additionally, I will expand this encapsulation possibilities to magnetic nanoparticles. HsrELPnano will enlarge the scope of the pathway-dependent co-assembly of ELPs. A further understanding and control of these assembly mechanisms will contribute to expanding the toolbox of stimuli-responsive systems, especially to their application as drug delivery systems. The final goal is to design novel ELP nanocarriers that can deliver a treatment in vivo under specific stimuli as pH, redox environment by therapeutic agents and magnetic hyperthermia. To carry out this project, ELPs will be engineered to assemble into nanoparticles above physiological temperature followed by internal crosslinking to retain their structure also below the Tt. Since the crosslinkers can be designed to render this susceptibility to specific triggers the coacervates will disassemble under these stimuli, releasing their payload within the target tissue. This a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'From Mutations to Metastases: Multiscale Mathematical Modelling of Cancer Growth and Spread'.

assistant: **Concept**

Cancer is one of the major causes of death in the world (particularly the developed world), with around 11 million people diagnosed and around 7 million people dying each year. The World Health Organisation predicts that current trends show around 9 million will die in 2015, with the number rising to 11.5 million in 2030.    Cancer growth (viz. solid tumour growth) is a complicated phenomenon involving many inter-related processes across a wide range of spatial and temporal scales, and as such presents the mathematical modeller with a correspondingly complex set of problems to solve.  This proposal will develop multi-scale mathematical models for the growth and spread of cancer and will focus on three main scales of interest: the sub-cellular, cellular and macroscopic.  -- The sub-cellular scale refers to activities that take place within the cell or at the cell membrane, e.g. DNA synthesis, gene expression, cell cycle mechanisms, absorption of vital nutrients, activation or inactivation of receptors, transduction of chemical signals.  -- The cellular scale refers to the main activities of the cells, e.g. statistical description of the progression and activation state of the cells, interactions among tumour cells and the other types of cells present in the body (such as endothelial cells, macrophages, lymphocytes), proliferative and destructive interactions, aggregation and disaggregation properties.  -- The macroscopic scale refers to those phenomena which are typical of continuum systems, e.g. cell migration, diffusion and transport of nutrients and chemical factors, mechanical responses, interactions between different tissues, tissue remodelling.   The proposal is multi-disciplinary in nature and aims to develop quantitative, predictive mathematical models of solid t