RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evolutionary Conservation of Regulatory Network Controlling Flower Development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This research exchange programme focuses on plant reproduction. The world population depends for its nutrition on agricultural crop products, mainly as seeds and fruits. Improvements of crop plants to achieve better yields under suboptimal growth conditions will be essential to keep up with the increase in world population and to reduce the impact of high yield farming on the environment. Most agricultural products, such as seeds and fruits, are derived from the reproductive process of flowering plants. Therefore, crop improvement requires a detailed understanding of flower and fruit development. Research on reference species, such as Antirrhinum, Arabidopsis and rice have revealed interconnected regulatory networks based primarily on transcription factors that guide the patterning and growth of flowers and fruits. We will focus on a fundamental, economically important and experimentally tractable biological system, plant reproduction, and we will take advantage of genomic and post-genomic tools to analyse the regulatory network controlling reproductive process. To obtain maximum benefit from a broad comparative analysis, we will focus on a key set of genetic interactions that clearly regulate flower development and cell fate in the reference species. However using a comparative approach, we aim to understand how evolutionary variation led to differences and/or similarities in reproductive processes in (crop) species. Detailed analysis of the network of regulatory genes controlling reproductive development in Arabidopsis represents the biological theme around which our training programme is built. The exchange of researchers between Italy, Spain, Mexico and Brazil will allow an intense collaboration between the research groups that will lead to the transfer of knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cortico-Spinal Motor Neurons in Amyotrophic Lateral Sclerosis : Contribution, Mechanisms and Therapy' (CORTICAL-ALS) under Seventh Framework.

assistant: **Objectives**

The long-term goal of this proposal is to shed light on the contribution of cortical upper motor neurons to amyotrophic lateral sclerosis, in order to design and test alternative therapies based on the protection and/or the replacement of this exact neuronal population.Amyotrophic Lateral Sclerosis (ALS) is the most common and the most severe adult-onset neurodegenerative disease of the motor system, leading to death two to five years after diagnosis. ALS is clinically defined as the combined degeneration of two specific neuron types: upper motor neurons (UMN, corticospinal motor neurons), located in the cerebral cortex and that extend axons to the medulla and spinal cord, and lower motor neurons (LMN, spinal motor neurons), located in the medulla and spinal cord and that connect to the skeletal muscles. This dual neuronal impairment distinguishes ALS from other, much less severe, motor diseases affecting either UMN only or LMN only. Despite this clear description, it is striking to note that preclinical studies on ALS have, so far, mostly focused on LMN.Recent advances in the fields of corticogenesis have provided scientists with new molecular implements allowing now to bypass the cellular complexity of the neocortex, and to study specific cortical neuronal subtypes (e.g. UMN), not only in the embryo but also in the diseased adult mouse.  Here, we propose to take advantage of these new tools, to understand the role of specific UMN degeneration in the onset and progression of ALS. More specifically, we will i) determine whether specific UMN degeneration in ALS induces, results, or is independent from LMN degeneration; ii) unravel the molecular mechanisms that trigger specific UMN degeneration in ALS; and iii) induce the generation of new UMN, within the brain of the dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Control of myotube growth for the generation of synthetic muscular micro-actuators' (MYOFORCE) targeting Horizon Europe.

assistant: **Abstract**

Millions of years of natural evolution have refined cellular tissues into exceptionally sophisticated materials. Not only they present the widest spectrum of mechanical properties, but they also self-organize, generate forces at different scales, react to external stimuli, and self-heal. Exploiting the unique features of tissues to build biohybrid actuators is thus the new paradigm in soft robotics. Muscular (myo-) tissues, composed of myotubes, are highly contractile and have become the main choice for the design of biohybrid actuators, typically millimetric hydrogel objects embedding muscle cells. Importantly, due to a combination of factors, including a lack of control on myotube growth, poor integration of the myotubes with their environment, or slow nutrient perfusion, artificial muscular tissues have so far displayed significantly low efficiencies compared with natural muscle. Furthermore, current biohybrid actuators hinder both the characterization of myotubes’ architecture and the mapping of forces at the myotube scale. To overcome these limitations, we propose a new approach to prepare biohybrid actuators based on the control of myotube growth at the microscale. First, we propose a platform to grow myotubes with controlled size and shape, and to characterize their contractile behavior. By using this platform, I will be able to investigate the interplay between myotube architecture and force generation. Second, we propose a set of fine-tuned artificial scaffolds, which will guide myotube growth and self-integration, leading to active composites able to generate specific mechanical tasks. Finally, to tame the self-contractility of the active composites, optogenetically-modified myotubes will be incorporated, allowing external actuation with light. This proposal p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing Multifunctionally Optimal composite Structures for construction and transportation applications with an emphasis on environmental sustainability' in the context of a Horizon Europe call.

assistant: **Objectives**

Due to unmitigated global warming, the EU has suffered unprecedented heatwaves in 2022 resulting in over 12,000 deaths and Europe's worst drought in 500 years. This is attributed to the heavily fuel-dependent construction and transportation sectors - collectively responsible for around 60% of EU's greenhouse gas emissions in 2020. The chief reason lies in these industries' over-reliance on legacy/outdated component architectures, with limited life-cycles and non-optimal functional performance. Consequently, there is an urgent ecological-societal need and associated research challenge for tailoring alternative optimized composite structures that are sustainable, eco-friendly and suited for commercial deployment. MultiOpStruct aims to deliver an integrated design environment capable of addressing these concerns by adopting a highly inter-disciplinary methodology inspired by the “material-by-design” outlook; and greatly expanding the current state-of-the-art by coordinating cutting edge research. On the modelling side, the work will develop a novel, rapid and high-fidelity physics-based method custom fit for analysing such complex components. On the design side, the project will deliver the first ever Hybrid Multiscale-Artificial Intelligence Topology Optimization toolbox for multifunctional lightweight Additively Manufactured (AM) Composite structures with increased durability and thermal-vibro-acoustic isolation; and decreased net-costs. This will reduce fuel dependency and associated emissions - and subsequently alleviate problems induced by climate change, e.g., glacier retreat. These goals are strongly aligned with the Circular Economic Action Plan, European Green Deal and Fit for 55 policy. For succesful completion, the proposed research plan brings together an enthu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'innovAtive ENErgy storage systems onboArd vesselS', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

AENEAS aims to contribute towards climate-neutral and environmental friendly water transport through three new next generation clean energy storage solutions. Eventual impact is an increase of the global competitiveness of the EU waterborne transport sector by European technology leadership for energy storage solutions for diverse waterborne applications. It will focus on increased and early deployment of climate neutral energy storage solutions and significant electrification of shipping. AENEAS will provide solutions to improve overall energy efficiency and drastically lower energy consumption of waterborne transport vessels, founded upon innovative electric energy storage, which is safe and cost competitiveness compared to traditional batteries.  To achieve this, AENEAS will develop three innovative electric Energy Storage Solutions (ESS) for waterborne transport, which are advanced beyond the traditional battery systems: -Solid-state batteries (SSB) for constant load waterborne transport applications.-Supercapacitors (SC) for water-borne transport applications for shaving of power peak demands and peaks during loading.-Hybrid system, which combines SSB and SC for waterborne transport applications requiring high energy and power density energy storage solutionsThe solutions enable (partial or full) electric shipping, taking into account conditions specific ships might encounter, including adverse conditions outside sheltered waters or going upstream on rivers. AENEAS will evaluate them for a range of applications and end uses in short-sea shipping and in-land waterways. For each of these three ESSs, one use-case will be demonstrated at TRL 5. At the same time AENEAS will define the pathway for the three ESSs for application in different ship types, achieving a compre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Shaping of axonal complexity by a dynamic regulation of local metabolic pathways in the developing cortex' (NEUROMET) under Horizon 2020.

assistant: **Objectives**

The proper function of neuronal circuits in the adult brain relies heavily on glucose metabolism to ensure energy-demanding neuronal functions such as synaptic activity or long distance axonal transport. Deregulation of the energetic metabolism is strongly associated to many neurodegenerative diseases and has been linked to some neuropsychiatric diseases such as schizophrenia. However our current understanding of metabolic regulation in the developing brain and in particular in rapidly growing neurons is still fragmental.I recently identified a novel function for the kinase LKB1 in the control of axon outgrowth and terminal branching in the mouse cortex (Courchet et al. Cell 2013). This novel function of LKB1 involves the kinase NUAK1/ARK5, a poorly studied kinase related to the metabolic regulator AMPK. Furthermore our work uncovered a completely novel mechanism by which LKB1 and NUAK1 control terminal axon branching through the capture of mitochondria at nascent presynaptic sites. However the roles of presynaptic mitochondria in developing neurons and how they contribute to axon morphogenesis remain an open question.In this project I will to study how the regulation of glucose metabolism and mitochondria function by LKB1 and NUAK1 underlie neuron development and circuit formation in the neocortex. We will develop techniques combining live imaging of fluorescent metabolic reporters, functional metabolomics and in vivo manipulation of gene expression in mouse models to identify the relationship between glucose metabolism and axon development. My experimental plan will revolve around three independent aims that will tackle this question from a subcellular scale to circuits in vivo.Overall, this project will provide new insights into the molecular mechanisms underlying th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of large eddy simulation techniques for turbulent combustion' (1994-1998).

assistant: **Concept**

Research objectives and content Large Eddy Simulation (LES) techniques have been given much attention over the last two decades. After a period at the academic stage, LES is now recognized as a high potential methodology for industrial simulation of turbulent now. Application to combusting flows has nevertheless not yet been acomplished, only tentative approaches have been reported Additional problems that have to be solved when combustion is to be simulated include large scale reaction rate modelling and coupling between turbulence and chemical reactions. In this project different approaches to LES of combustion are to be investigated, based on statistical modelling of small scale reaction and mixing trough the probability density function (PDF) methodology. With the final objective of application to industrial combustion systems, the performance and cost of the different approaches is to be evaluated. Training content (objective, benefit and expected impact) The applicant has been working towards her PhD thesis in the area of modelling turbulent reacting flows, developing a methodology that combines LES with simulation of the evolution of the probability density function of reactants. As a first approach the method has been developed for the simplified case of constant density reacting flows. Extension to real combustion, that is. variable density flows with heat release, is the next step in her work.CERFACS provides an excellent frame for this work due to their recognised expertise in the field of combustion simulation and the strong activity towards LES of combustion they are developing with multiple partners in Europe. This stage at CERFACS would thus be a great opportunity for the applicant to work together with the European experts in the field.Links with industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Engineering zinc fingers to target cancer hub genes'.

assistant: **Objectives**

For the last ten years, protein engineering technologies have been developed to make zinc finger peptides to recognise a wide variety of user-defined DNA sequences. This has enabled the construction of synthetic transcription factors that can upregulate or repress target genes at will. More recently, synthetic zinc fingers have been linked to nucleases to direct double stranded breaks at desired loci within genomes. These breaks increase the efficiency of homologous recombination so that, by providing an exogenous repair sequence, it is possible to repair or mutate endogenous genes. Although zinc finger engineering has reached a state of maturity, there are very few groups in the world who have the technical know-how to adopt this technology, and this has delayed general uptake. We will use the expertise we have developed, in both zinc finger engineering and gene repair, to construct zinc finger proteins to recognise some of the most highly-connected (and widely-studied) genes in biology. This will serve as a toolkit for the research community to target hub genes and either mutate or repair them. As a starting point we propose to target the following hub genes: TBP (TATA-binding protein), p53, p300, RXR, pRB, RelA, c-jun, c-myc, and c-fos. These genes are the most connected hubs in the human transcription factor network (TRANSFAC 8.2 database) and their mutants are associated with a variety of diseases. We will engineer and characterise zinc finger proteins that recognise these DNA sequences in vitro and induce gene repair in vivo. For example, this will allow cancer cell lines to have particular oncogenes repaired or mutated, within the context of all the other mutations that have been accrued during the process of oncogenesis. This will help to characterise the contri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ethical codes in nursing: european perspectives on content and functioning' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This study will make recommendations for harmonizing ethical standards of professional behaviour in nursing on national and European levels. Using philosophical analysis, value clarification methods and focus group methodology it will analyse, clarify and describe the contents and functions of ethical codes for nurses from six European countries. It will draw directly on the experiences and opinions of users of ethical codes and key persons, clarifying practical, ethical, deontological and disciplinary aspects and cultural and inter-country variations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigating the predictors of intimate partner violence: A mixed method longitudinal study in Tanzania' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This study proposes a major advance in research on intimate partner violence (IPV), a prominent public health and human rights issue. Worldwide, it is estimated that one in three women experience physical and/or sexual violence by a partner in their lifetime, with even higher rates reported in sub-Saharan Africa (WHO 2013). Cross-sectional surveys have documented the adverse health impacts of IPV and the factors that increase risk of female victimisation and male perpetration. Nonetheless, theoretical and programmatic development has stalled due to lack of clarity on the temporality of identified associations: do documented associations represent risk factors for violence or do they reflect the consequences of abuse? This deficit of understanding is especially pressing in low and middle income countries (LMICs) where few longitudinal cohort studies with IPV as an outcome exist. This study seeks to address this gap by following forward in time a cohort of 1200 Tanzanian women, using state of the art methods to measure violence, encourage disclosure and ensure participant safety. Both quantitative and qualitative data will be collected at 4 discrete time points over 5 years, making this the largest longitudinal study of IPV ever undertaken in the developing world. In addition, an in-depth study of 40 men and a cross-sectional survey of 600 men will be conducted. The goal of the research is to advance our understanding of the predictors and consequences of IPV to better inform the design of interventions to reduce violence in LMICs.  Specifically the study aims to: 1) advance the theoretical frameworks of intimate partner violence; 2) investigate the temporality of key factors linked to IPV; 3) map the dynamics of partner violence over time; 4) and investigate pathways lea