RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Gluten Epitope Molecularly imprinted polymer Sensor'.

assistant: **Innovation**

Introduction-state of art of the problem: The main goal of the present proposal is to devise a chemical sensor capable of gluten detection in food. Gluten is the allergen that triggers autoimmuno reactions in people suffering of celiac disease (CD). CD is an autoimmune disorder, characterized a variety of genetic assets, which is estimated to affect the 1-2 % of the European population with direct costs on the healthcare estimated as 3 bn Euros/year. According to the state of the current knowledge gluten-free diet is mandatory in CD. Food shall contain less than 20 mg/kg gluten of to be considered as “gluten-free” and to be eaten safely. Scientific part of the project: To face the problem of CD we are coming with the idea to devise a chemical sensor capable of fast gluten detection in food. To complete this task, we will design a recognition unit using the technology of molecularly imprinted polymers (MIPs), which allows to produce synthetic receptors by a template assisted synthesis. Being gluten a mix of proteins (prolamins) the design of the MIPs will be rationalized by the aid of the epitope imprinting methodology, that complements protein 3D- and linear sequence-databases, so to find distinctive portions of the protein to be used as templates. The next step is an electrode-MIP preparation based on thiophene monomers that will proceed through a foregoing rational design of the monomers selection by computational methods. In the third step we will focus on the study of the performance of the sensor both in model solutions and in real samples. Finally, validation on true samples will be performed by comparing our results to independent analytical methods.Expected outcomes and impact of the work: As result of the proposed project, the laboratory model of the working gl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Metabolic imaging of the joint' in the context of a Horizon 2020 call.

assistant: **Objectives**

Osteoarthritis is a painful and disabling life-altering joint disease and the most common form of disability in our society. There are very limited treatment options for osteoarthritis and in most cases, osteoarthritis is slowly progressive, sometimes over a period of decades. More than 10% of entire the population in Europe has osteoarthritis in knee, hip or hands that leads to disability, pain and limited quality of life.   In the METAJOINT study we propose to test new metabolic imaging methods of joint disease using MRI that can visualize the distribution of specific elements such as sodium, phosphorus and deuterium. As these elements are taken up in the tissue dependent on disease characteristics, the method can identify tissue turnover or metabolic aspects of the diseased or healthy joint, whereas conventional MRI detects hydrogen protons that provide only the amount of tissue such as cartilage thickness or volume. The aim of METAJOINT concerns the scanning of a limited set of a total of 15 patients for three imaging methods to scan for respectively phosphorus, sodium and deuterium, showing - for the first time – subchondral bone turnover through uptake of bisphosphonates, sodium retention in cartilage in patients with high salt concentration, and glycosaminoglycan turnover in cartilage through uptake of heavy water. This new ground-breaking evaluation method for joint disease will help pharmaceutical companies with better outcome measures in order to find disease modifying medication that can treat osteoarthritis and it can be used by physicians and surgeons for early detection of osteoarthritis and early prediction of the course of the disease, which helps to better guide patients with early or late phase osteoarthritis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Robust and reliable general management tool for performance and dUraBility improvement of fuel cell stationarY units' (RUBY) under Horizon 2020.

assistant: **Objectives**

RUBY aims at developing and implementing a tool able to perform integrated Monitoring, Diagnostic, Prognostic and Control functions for production μ-CHP and Backup (BUP) systems, based on SOFC and PEMFC.   The proposal is the final step toward the production, installation and commercialization of stationary FCSs with new management functions that will enhance system lifetime, stack durability, availability, reliability and overall performance with improved efficiency. These enhancements will lead to TCO reduction, paving the way toward advanced maintenance service implementation, less cost and increased warranty periods, leading to a better customer satisfaction.  RUBY leverages the findings of the last 8 years applied research that contributed to move the FC technologies towards the same maturity of market-available conventional energy conversion technologies. The key-feature of RUBY tool is the Electrochemical Impedance Spectroscopy (EIS)-based advanced monitoring of both SOFC and PEMFC stacks, which has been demonstrated viable for its implementation on FCSs. RUBY will finalize the work on the hardware integration with stack diagnostic and control algorithms as well as with fault detection algorithms for BOP. Then, condition monitoring algorithms will be built along with prognostic and advanced adaptive control functions. The holistic vision of the FCS and a thorough knowledge of the State of the Health will be used to evaluate the lifetime of FCS components for improved supervisory control. Artificial Intelligence-based algorithms will be exploited to elaborate grid and FCS data toward the development of control functions for perspective VPP management and future integration with smart-grid.  One-year tests will be conducted in real environment for certified μ-CHP a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A frictionless two-factor authentication software for secure transactions' (EyeCode).

assistant: **Concept**

Around €1 trillion in mobile financial transactions were made in 2016, and up to €480 billion resulted to be stolen by hackers. Online crime is estimated at 0.8% of worldwide GDP, with developed countries in regions including Europe and North America being the most affected.Eyecode is a two-factor authentication solution offering secure transaction validation. It leverages two breakthrough cryptography technologies – immune code execution and cryptographic retinal photography – to protect banks/FinTechs and their customers against the escalating threat of cyber-attacks. Instead of receiving an SMS from their bank, users will receive a virtual token via an app on their phone – which they use to validate a transaction. The service offers equivalent security to “chip and pin” hardware solutions – with single device convenience. The easily deployable, cost effective solution doesn’t rely on smartphone hardware either, which increasingly erodes banks’ customer ownership. Given the stakes and high profile attacks, banks are crying out for secure solutions. In Europe, this is regulation-driven too. In Phase 1 Skeyecode will validate market potential, commercialisation strategy and planned software engineering scale-up actions. The Phase 2 project will be used to run independent penetration tests, to boost credibility; to obtain certification from ANSSI (the French NSA); and to carry out the development required to service proof of concept contracts currently being concluded with large French banks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Molecular Communication Mechanism of Motor Neuron Survival and Synapse Maintenance' in the context of a Seventh Framework call.

assistant: **Objectives**

In order to survive and maintain normal function, the cell depends on a dynamic system of spatial specificity and fidelity of signaling pathways that can respond to both internal and external changes over space and time. This cell-cell communication is mediated by ligand-receptor mechanisms. In the case of highly polarized cells such as neurons trafficking mechanisms mediated by motor proteins are used to achieve precise signal targeting. Alterations in the trafficking machinery may results in incorrect signaling, that in some cases leads to neurodegeneration. An example for such phenomenon may be found in Amyotrophic Lateral Sclerosis (ALS). ALS is a motor neuron disease characterized by a non-cell autonomous neurodegeneration process, which involves neighboring cells via an unknown mechanism. This proposal focuses on the elucidation of basic cell-cell communication mechanisms by using the motor neuron degeneration process as a model. I aim to reveal critical communication mechanisms between the neuron and its environment for cell survival and synapse maintenance. My working hypothesis is that alterations in extrinsic and intrinsic signals may lead to the neurodegeneration seen in ALS. I will develop unique compartmental platforms mimicking the natural environment of the motor neuron. Then using differential “omics” approaches followed by functional assays I will reveal and characterized vital factors essential to neuron synapse integrity and neuron survival. Using state of the art live-cell imaging techniques I will reveal also the molecular mechanism for signals localization and targeting driven by the motor protein dynein. I will elucidate the molecular mechanism of neuronal communication with its diverse environment essential to its survival and proper function.  T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UPSCALE OF AN INNOVATIVE AND SUSTAINABLE BIOMATERIAL FOR THE LEATHER INDUSTRY' (BacLEATHER).

assistant: **Innovation**

Turning animal skin into leather requires significant energy, and harmful chemicals, and releases substantial amounts of greenhouse gasses. Alternative synthetic leather is not an option since it is a highly polluting industry. We are using biotechnology to address the development of high-performance, animal-free, and more sustainable materials for the fashion, automotive, and home goods industries. We produce BacLEATHER, an eco-friendly material from microorganisms through an efficient and low-cost bio-production and proprietary process. Our technology provides solutions to the problems facing the leather industry, as our biomaterial has the same performances as the animal ones but are cleaner to produce (independent from animals, fossil-derived, and toxic chemicals), safer to wear, and ready to be used for manufacturers. BacLEATHER belongs to the nascent “next-gen materials industry” with a CAGR of 80% annually (2020-2026). Willingness to pay has already been confirmed with potential clients and we have established a collaboration with TEMPE, from GRUPO INDITEX (one of the most important brand footwear companies, owner of ZARA brand, among others) to prepare and validate the material for its market-fit within the footwear vertical. In 2022, Next-Gen Leather was funded by seed capital investors BeAble to exploit the technology previously developed by Patent Shoes,SL. Next step to develop this innovation will be to set up a pilot manufacturing plant so we are applying for Horizon Europe EIC Accelerator calls. But also we need to deploy our market positioning strategy to achieve the maximum visibility of our product and technology among all relevant stakeholders, clients and the public. In this sense, the support offered by Women TechEU Program will allow us that to desi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced meteorological pre-processing for application to real-time modelling of atmospheric dispersion in Decision-Support Systems' (2002-2006).

assistant: **Concept**

The main objective of the proposed research activity is the improvement of the quality and accuracy of the meteorological input data for the atmospheric dispersion models (ADMs) operated in the frame of decision support systems (DSSs) that are used for real-time handling emergency situations in cases of accidental or deliberate releases of hazardous pollutants (radioactive, toxic, flammable) in the atmosphere.This objective will be realised through the combination of advanced diagnostic meteorological modelling approaches with three-dimensional data assimilation procedures (3DDA) that are based on variational principles in a meteorological pre-processor (MPP) acting as interface between the available meteorological data and the above-mentioned ADMs. Advanced numerical techniques will be used to achieve real-time applicability of the developed procedures.The developed methodologies will enable the simultaneous use of data originating from external Numerical Weather Prediction (NWP) models and from meteorological stations in the area of interest, and the accurate calculation of local-scale features of the wind flow over highly complex terrain through an advanced operational diagnostic wind flow model. This will substantially improve the quality of the ADMs' output, as well as the credibility and confidence given to the final DSSs results.The above target will be realised through the following specific activities:1) development of advanced methodologies of meteorological pre-processing (diagnostic meteorological modelling with 3DDA) together with implementation of efficient numerical methods;2) testing, and evaluation of developed methodologies directly through comparisons with meteorological data from field experiments and indirectly through the results of ADMs and produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanisms of Inflammation Resolution: Role of miRNAs' under Seventh Framework.

assistant: **Concept**

The elucidation of endogenous pathways and chemical mediators that activate resolution of inflammation is crucial to identify new therapeutic approaches to control excessive inflammation and related diseases. Inflammation and resolution are actively regulated processes, during which a temporal switch in leukocyte populations present in the exudates occurs, likely reflecting changes in bone marrow (BM) hematopoietic stem cells (HSC). Biosynthesis of the specialized pro-resolving lipid mediators (SPM) lipoxin (LX) A4 and resolvin (Rv) D1 also occurs. SPM promote inflammation resolution by regulating leukocyte trafficking as well as the expression of selected microRNAs (miRNAs) via the G-protein coupled receptors (GPCR) FPR2/ALX and GPR32.Here, we propose to investigate: 1) Whether resolution is regulated at the BM level by specific proresolving miRNAs, whose expression is modulated by LXA4 and RvD1; 2) Which processes are controlled by these miRNAs.We plan to achieve the outlined specific aims by a system approach to inflammation and resolution. Using self-limited murine peritonitis, we will identify SPM-regulated miRNAs by analyzing temporal changes in the miRNA profile of BM HSC, at resting and upon exposure to LXA4 and RvD1. GPCR-dependence of LXA4 and RvD1 actions will be assessed in experiments with FPR2/ALX or GPR32 recombinant cells. A gain of function approach will be employed to identify target genes of proresolving miRNAs, and assess their roles in HSC differentiation and inflammation. Results from these experiments will help to elucidate key pathways that can be exploited to introduce innovative therapeutic strategies to treat inflammation-related diseases in humans by promoting resolution.Funding this proposal will reinforce excellence and competitiveness of E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Surface receptor-induced apoptosis in transformed cells : defining the molecular events involved in TNF-R1 and Fas / APO-1 apoptotic signalling' under Fourth Framework.

assistant: **Concept**

Aim of the project is the definition of the molecular requirements for the generation and intracellular transmission of the apoptotic signal from surface receptors in transformed cells.As surface receptor-mediated apoptosis induction is a key mechanism exploited by immune effect cells to eliminate cancer cells, understanding the biochemical nature of the apoptotic signal is of major relevance in cancer biology. The model we are using in the human system is represented by two highly related receptors, widely expressed on a variety of normal and transformed cells, the tumour necrosis factor receptor type 1 (TNF-R1) and the Fas/APO-1 receptor. Crosslinking of TNF-R1 and Fas/APO-1 by their specific ligands triggers a cascade of still largely undefined events, eventually leading to cellular apoptosis. TNF-R1 and Fas/APO-1 are trimeric receptors which share extended structural homology, including a cytoplasmic region which has been named 'death domain', as deletions or mutations within it result in the inability by the respective ligands to grigger apoptosis. Structural similarities both in the extracellular and in the intracellular portion of the two receptors suggest similar mechanisms for the generation of the apoptotic signal, however differences may exist in the complexity of its fine regulation and control, which may be relevant for the specialisation of the death signal in different cell types. Our goal is to define the mechanisms for signal generation and propagation from the two receptors, identifying common central relays as well as unique control features of each apoptotic pathway. We will address receptor structural requirements for productive lingand/receptor interactions, with particular emphasis on the role of alternatively spliced isoforms of the Fas/APO-1 rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neuropeptide regulation of social feeding behaviour in the nematode c. elegans' to be submitted under Fifth Framework.

assistant: **Abstract**

Wild strains of c. elegant display either solitary or social feeding behaviour. This natural variation is associated with polymorphism in the nor-1 receptor. The proposed research is aimed at isolating components involved in the proper expression, processing and release of the neuropathies legend, flip-21.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cell cycle clock in nervous system and cancer' (CYCLOCK) under Seventh Framework.

assistant: **Objectives**

Cyclins play role in the cell division machinery and dictate the proceeding of cell cycle phases. D-type cyclins activity is required for progression through G1 phase, the critical step when cells steer the wheel to enter a new cycle of proliferation, to exit cell cycle and become quiescent or ultimately to differentiate. Generation of mice nullizygous for each of the three D-cyclin genes revealed their physiological impact as well as protective effect against cancer. Cyclin D1 is important during nervous system development, in particular for the retina and the cerebellum. However, cyclin D1 is also directly involved in the proliferative response of estrogen receptor alpha positive breast cancers and over-expressed in HER2 (ERBB2) dependent breast cancers. Recently, we reported a genome-wide function for cyclin D1 in transcriptional regulation, acting physiologically during retinal development. To affect protein production, it has been reported that transcriptional regulatory events need to be coupled with the nuclear export machinery, optimizing transfer of neo-synthesized RNAs to the cytoplasm. This suggests transcription and RNA export are spatially and temporally interconnected rather than stochastic separated phenomena. Hence, we intend to define how cyclin D1 activity governs interactions between the nuclear export and transcriptional machinery during nervous development in comparison to cancer situation. This research project relies on innovative genetics thanks to tandem tagged (Flag-HA) cyclin D1 mice model, together with modern proteomics and genomics approaches. We explore the transcriptional loop operating during cerebellum development in comparison to medulloblastoma genesis, and we extend our study to ERBB2 and ER-dependant breast cancer on the other hand.