RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interkingdom Signaling between Bacillus subtilis and Sporisorium scitamineum: Exploiting the Ecological Role of Natural Product as  Novel Biocontrol Agents' (LIPQUORUM), addressing dissemination and exploitation.

assistant: **Impact**

Global food security and sustainable agriculture challenges demand innovative crop protection approaches. This project investigates interkingdom signaling between beneficial bacteria (Bacillus subtilis species complex) and a fungal pathogen (Sporisorium scitamineum) causing sugarcane smut disease. While bacterial lipopeptides are known for their antimicrobial properties, their potential as signaling molecules at sub-inhibitory concentrations remains unexplored for basidiomycete plant pathogens. This research aims to unravel how lipopeptides (iturin A, fengycins, and surfactins) impact S. scitamineum's growth, morphology, mating, and virulence in sugarcane. I will characterize lipopeptide effects at various concentrations, investigate their impact on fungal virulence, elucidate underlying molecular mechanisms, and explore their ecological relevance in soil and on plant surfaces. Using advanced techniques like High-Performance Liquid Chromatography-Tandem Mass Spectrometry, RNA-seq, and High-resolution Desorption Electrospray Ionization, I'll reframe traditionally viewed antimicrobial compounds as potential signaling molecules. The project includes greenhouse trials at the Netherlands Institute of Ecology, enhancing its translational aspect. This Marie Skłodowska-Curie Action program at Leiden University, supervised by Prof. Ákos T. Kovács, will advance scientific knowledge and provide comprehensive training in research techniques, project management, and science communication. The project's interdisciplinary nature, combining microbiology, biochemistry, and agricultural science, will foster new collaborations and enhance career prospects.By bridging fundamental research with practical applications, this project may revolutionize our understanding of microbial ecology in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Imagine (if) Platforms. European Progressive Parties and the Digital Commons. Mapping Ideologies and Practices. Comparing Political Imaginaries. Measuring Societal Impacts'.

assistant: **Concept**

Putting the ‘people at the centre of the digital transformation’ is one of the core goals of EU strategies for the digital decade. However, the excessive power of a few non-European big tech companies governing the digital transition also carries risks for EU citizens. While state-of-the-art theorises and describes the new opportunities and threats of the political impacts of ‘platformisation’, the question of whether and how a new progressive politics for the digital age is emerging is rarely asked. IMDIGICOMM will answer these questions in four steps.First, building on critical literature on the ‘digital commons’, IMDIGICOMM will elaborate a three-pillar theoretical framework to make sense of how digitalisation affects gender, democratic and productive relations. The assumption underlying IMDIGICOMM is the emergence of a new cleavage counterposing two models of platformisation: the ‘digital as commodities’ and the ‘digital as commons’. Second, empirical research will focus on Progressive Parties in five countries (France, Germany, Italy, Poland and Spain) to map their ideologies and practices regarding the digital transition to assess whether they facilitate or hamper the advance of the 'digital commons'. Third, the maps will result in a ‘Digital Commons Politics’ Index to measure the extent to which parties’ imaginaries on platform societies contribute to redirect the digital transition, and Qualitative Comparative Analysis will assess the combination of conditions that may lead to an increase in the index. Fourth, the project will evaluate the societal impacts of transformative shifts from the ‘digital as commodities’ to the ‘digital as commons’ through a digital dashboard. IMDIGICOMM represents a stepping stone to elaborate the theoretical and methodological tools
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Twinning for excellence in migration and integration research and networking (MIRNet)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The specific objectives of the MIRNet project are as follows: 1) to institutionalize migration and integration research carried out at Tallinn University by establishing the Migration and Integration Research Centre (MIRC); to advance the quality and volume of research on migration and integration issues in cooperation between the MIRNet project partners; to advance networking between academic researchers, policy makers and other stakeholders in the field of migration and integration in Estonia and the MIRNet partner countries; to advance public dissemination skills of the MIRC regarding the research results in the field migration and integration. These objectives will be achieved in partnership between Tallinn University (TU), Sussex University (UoS), Roskilde University (RU) and University of Tampere (UTA). The Sussex Centre for Migration Research is one of the largest and most widely respected specialist migration research institutes anywhere in the world and home to the Journal of Ethnic and Migration Studies, the highest-ranked interdisciplinary migration journal in 2016. Roskilde University is a leading research institution in the region focusing on a broad range of topics in the field of ethnic relations and nationalism, including migration and integration, the politics of diversity and linguistic minorities. Research Centre on Transnationalism and Transformation at the University of Tampere is a leading multi-disciplinary network organisation focusing on the ways in which an increase in transnational activities is connected to political, socio-economic and socio-cultural transformation in different parts of the world. The experience, knowledge and authority of these three leading research institutions in the field will provide a perfect guide to Tallinn Universi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Therapeutic Atmospheres' (THERASPHERES).

assistant: **Innovation**

Mental health challenges represent one of the most pressing issues of 21st-century science, with an estimated 9% of the population currently experiencing a mental disorder and 25% expected to face one at some point in their lives. As these challenges become increasingly prevalent, the importance of understanding what contributes to effective healing cannot be overstated. While existing research recognizes that the environment in which therapy occurs—such as the layout, lighting, sound, and furniture of a room—can significantly influence therapeutic outcomes, there remains a notable gap in the literature regarding how these therapeutic spaces affect individuals and shape the course of psychotherapy.The ""Therapeutic Atmospheres"" (THERASPHERES) project seeks to address this gap by exploring how the experience of affective atmospheres within therapeutic settings impacts the effectiveness of therapy, particularly in forming therapeutic alliances and fostering significant therapeutic change events. The primary objectives of this project are threefold: (1) to map the various interpretations of 'atmosphere' within the literature on phenomenological psychiatry and situated affectivity, (2) to assess how the experience of atmospheres in consultation rooms influences therapeutic change processes, and (3) to refine existing conceptualizations of 'atmosphere' within the field of phenomenological psychiatry and situated affectivity and explore their application to other research domains. By employing a novel method that integrates phenomenological interviews with the analysis of video recordings, THERASPHERES will systematically assess the role of affective atmospheres in therapeutic processes. Ultimately, this project aims to enhance our understanding of how to create spaces that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Protein protein and dna protein transactions during gene activation activator sigma n contacts and the dna melting activity of the sigma n activator complex'.

assistant: **Objectives**

Determination of the critical protein-protein interactions in transcription systems and in particular between sigma-N and its activator, and the contribution of the sigma-N holoenzyme-activator complex to the DNA strand separation (melting) process are essential for the understanding of the mechanism of transcriptional activation of the RNA polymerase holoenzyme. The sigma-N protein is well suited to analysis as biochemically active domains have been isolated. The overall aims of the proposed work are to: (a) Locate the putative protein-protein interactions between activator and the sigma-N protein, that appear to be critical for activation of RNA polymerase holoenzyme. (b) Identify promoter DNA-contact regions of the sigma-N holoenzyme-activator complex during catalysis of open complex formation. (c) Mutate candidate DNA and activator contact regions of sigma-N identified as described above. Screen mutants defective in either a DNA contact during DNA melting and/or activation interaction. (d) Analyse the DNA-melting process, dependent of the formation of the sigma-N holoenzyme-activator complex.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanisms of Wnt Signaling Initiation' in the context of a Seventh Framework call.

assistant: **Objectives**

Wnt proteins dictate critical cell growth and lineage decisions during development and in adult tissue homeostasis. Inappropriate activation of Wnt signalling is a frequent cause of cancer. The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. The key objective of this proposal is to resolve critical molecular events that drive initiation of the Wnt cascade by focusing on two central questions: How does protein trafficking control Wnt signalling initiation? What molecular mechanisms underlie Wnt-induced formation and activation of multiprotein complexes? I will take a unique approach combining advanced live cell imaging and high resolution immuno-electron microscopy with sophisticated peptide chemistry, gene silencing and biochemistry to dissect early Wnt signalling events at the level of isolated molecules, in cultured cells and in complex tissues of living animals. With the proposed interdisciplinary work I expect to uncover where key Wnt signalling steps occur, which proteins are involved, how they direct protein complex assembly, trafficking and turnover and how these events control transmission of the Wnt signal. Mechanistic insight in how Wnt signals are transmitted is vital to understand how pathway specificity and sensitivity is controlled. Basic insight in these processes will be of utmost importance for the design of strategies to interfere with Wnt signalling in cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Paleomagnetism and rock-magnetism by Micro-Magnetic Tomography'.

assistant: **Objectives**

Our knowledge on the past behavior of the Earth’s magnetic field critically depends on our ability to obtain and interpret magnetic signals from geological materials such as lavas. These materials contain mixtures of different magnetic minerals, some of which are good recorders of the Earth’s magnetic field, others are not. Even the presence of a small amount of minerals with adverse magnetic properties obscures the signal of good recorders, resulting in >80% of measurements of the past Earth’s magnetic field strength being flawed. Understanding the Earth’s magnetic field is pivotal for predicting the future of its shielding capacity against the Sun’s electromagnetically charged particles, which globally weakened by >20% over the last millennium.With MIMATOM, I aim to establish an entirely new way to obtain paleomagnetic and rock-magnetic information from geological materials. I will go beyond measuring magnetizations of bulk samples by determining the magnetic moments of individual minerals embedded in these samples in a non-destructive way. Starting from my recent proof-of-concept of Micro-Magnetic Tomography (MMT), I will develop a radically new technique to assess magnetizations of individual minerals inside geological materials. This will enable understanding which minerals are reliable recorders of the Earth’s magnetic field by characterizing their magnetic behavior as function of their grain size, shape, and chemistry.  Then I will use MMT to obtain paleomagnetic information from selections of minerals that I identified as good recorders and unlock information on the past state of the Earth’s magnetic field from even the most challenging and magnetically complex geological materials, such as lavas.My revolutionary new technique will open archives of the past beha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Programmable NanoRobotics for Controlled Manipulation of Molecular Cargoes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Molecular machines are among the most complex of all functional molecules and lie at the heart of nearly every biological process. The controlled manipulation of molecular-level structures through programmable small-molecule robotics is a fabulous challenge that could lead us towards the dawn of an era of useful molecular nanotechnology.“ProgNanoRobot” project aims to design, construct and investigate the operation of artificial molecular nanorobots capable of transporting a molecule cargo in a programmable fashion. We will develop key methodologies needed to manipulate molecular fragments using a molecular robotic arm operating through the formation and cleavage of dynamic covalent bonds, building on a rotary switch in which the rotor and stator can be positioned with respect to each other. We will explore different component types to find the best programmable small-molecule robotic systems and develop a toolbox of robotic machine components. We will use them as the basis for molecular machines that can transport molecular cargoes of biological relevance over long distances and to select between different cargoes and move them between multiple sites on molecular platforms in either direction. Moreover, we will employ a chemical fuel that induces pH oscillations in the reaction medium to allow the autonomous operation of these systems, a key development to reach the full potential of molecular machines, which will enable them to work as effective molecular assembly lines.We envisage that the domain of this new generation of molecular robotics will be useful for the development of molecular-sized machines that can manipulate substrates to control sequence-specific oligomer construction and molecular manufacturing.


**Keywords:** Artificial molecular machines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of an innovative and safe ultralight two-seater turbine helicopter' under Horizon 2020.

assistant: **Concept**

Ultralight helicopters are used for a variety of transportation needs, attracting users from the recreational, private and public market segments because of their agility and convenient storage and transportation capacities. However, most ultralight helicopters on the market today are designed and manufactured with technology dating back to the 1980s. This creates a serious safety issue in adverse weather conditions. Indeed, ultralight helicopter accidents caused an estimated 57 deaths in Europe in 2013. The principal cause of these accidents is “Loss of Control-In Flight”. Many of these accidents could have been prevented with better ultralight helicopter designs and more powerful engines. The DISRUPT (Development of an innovative and safe ultralight, two-seater turbine helicopter) project is a state-of-the-art concept to manufacture a new and improved ultralight helicopter. Our helicopter design, turbine engine and parachute safety mechanism will make ultralight helicopter flights safer for passengers and reduce the number of tragedies caused by loss of pilot control.


**Keywords:** Ultralight helicopter, safety, turbine engine, reliability, Ballistic Parachute, microlight, flying, helicopter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Speciation and adaptive radiation in a Neotropical cichlid fish species complex: resolution of a systematic, ecological and evolutionary puzzle""' (GEM).

assistant: **Innovation**

Cichlid fish are among the most spectacular examples of rapid speciation and adaptive radiation, which makes them an excellent model system for the study of mechanisms of speciation and evolution. The hotspots of cichlid diversity are the large East African lakes, which contain hundreds of endemic species. Neotropical cichlids are less species rich, but often offer better and simpler scenarios to study very recent speciation events. A good model system of a small scale and extremely recent radiation are cichlids from the Cuatro Cienegas valley, in the Chihuahuan desert in Mexico. Fish so far assigned to the species Herichthys minckleyi have evolved during the last few thousand years and have developed an array of trophic and body shape morphologies in parallel in several isolated ponds. This has raised the hypothesis that in fact several recently formed species might be coexisting in these ponds. However, lack of concerted genetic studies mean this species complex remains an unsolved evolutionary mystery.  I plan to study the reproductive isolation of the incipient species using a comprehensive approach combining morphological and ecological characterization of the different species both in the laboratory and in captivity, and molecular markers distributed across the entire genome (SNP markers obtained using the most recent parallel sequencing technologies). I aim to understand the geographic setting and the mechanisms driving speciation, and the extent of parallel evolution causing similar eco-morphological outcomes in independent settings.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Doraya is an innovative catheter device for treating patients resistant to diuretics with Acute Heart Failure (AHF) condition.' (AHF), addressing dissemination and exploitation.

assistant: **Impact**

Acute Heart Failure (AHF) is a sudden worsening of the signs and symptoms of chronic heart failure, which typically includesdifficulty in breathing, leg or feet swelling and fatigue. HF is a growing global problem, affecting millions of people around theworld (present in 1%-12% in Europe and the United States. The lifetime risk of developing the disease ranging in between20%-33%). AHF is the most common cause of hospitalization for patients older than 65 years of age. Over the last 3decades, the hospitalization rates for patients with AHF has tripled and is expected to increase. An ageing population willincrease the prevalence of AHF, which in turn will lead to significant monetary expenses. Fluid decongestion is the keytreatment of AHF, where 90% of patients are treated with diuretics. However, 30%-40% of patients are resistant to diuretics.The DorayaTM is the first device to directly create an optimal hemodynamic environment, enabling diuretic efficiency torelieve congestion and restore organ function. The DorayaTM catheter regulates vascular hemodynamics in AHF patients,including those who have developed diuretic resistance. Chronic Heart Failure market is expected to increase from €2.64bnin 2015 to €8.78bn in 2025, which represents a 12.9% of CAGR. Since, AHF market accounts for 75% of the total ChronicHeart Failure market, the total available global market by 2025 is expected to reach €6.59bn. With 30% of patients resistantto diuretics, this represents a huge unmet market that Doraya can service.