RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VALidation of human PApilloma virus assays on Self-collected first void urine samples' (VALPAS) targeting Horizon 2020.

assistant: **Abstract**

Annually, about 13,000 women in the EU28 and 266,000 worldwide decease of cervical cancer caused by the human papilloma virus (HPV), thereby ranking third most common cancer worldwide . Throughout Europe, cervical screening programs are organized by local governments to detect cervical cancer at an early stage. Importantly, HPV-based screening (instead of cytology-based screening) is being implemented worldwide. However, a global challenge is that about 40% of women in the EU do not participate in these screening programs and are thus at-risk for development of cervical cancer. To reach these non-attendees, home self-sampling devices can increase the participation rate. The innovative Colli-PeeTM device developed by Novosanis offers a non-invasive, user-friendly solution. The device is suited for collection of first void urine (first 20ml of the urine flow) which allows for detection of HPV DNA. The Colli-PeeTM device thereby offers a novel innovative approach towards HPV-based screening.The VALPAS (VALidation of human PApilloma virus assays on Self-collected first void urine samples) project aims to successfully launch the Colli-Pee first void urine collection for HPV DNA testing in the EU28 and global market. The feasibility assessment in phase I aims to explore strategies with regard to market penetration & growth, competitors, pricing & reimbursement, partnerships, revenue models; ultimately leading to a business plan for Colli-PeeTM-based HPV screening. Specifically, phase I entails: - Market segment analysis- Competitor bench marking- Initiation of partnerships with diagnostic companies & labs- Exploration of pricing & reimbursement strategy- Assessment of diagnostic assays for analysis for HPV in urinePhase II funding will be requested to further validate the HPV
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plasticity at the tripartite synapse: an in vivo study of astrocyte-synapse interactions in the mammalian cortex' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The appropriate functioning of the brain requires co-operation between its cellular constituents – neurons and glial cells. While neurons have been widely studied thanks to their electrical excitability, the glial component has been neglected for years. However, recent research has brought surprising results indicating that astrocytes (a type of glia) can actively regulate the structural and physiological properties of synapses. Unfortunately, most of the data regarding astrocyte function originates from ex vivo studies, because the complexity of the nervous system meant it was impossible to study astrocyte function in vivo with the limited technologies available at the time. It is recent advances in imaging, together with the introduction of novel, genetically modified animals, which now allow us to investigate astrocyte-synapse interactions in situ.In this multidisciplinary project, I will combine state-of-the-art genetic, biochemical and imaging techniques to study the role of astrocytes in mediating dendritic spine plasticity. First, I will develop a method that allows the flexible generation of genetically modified mice showing astrocyte-specific gene targeting. Second, using these mice I will analyze the dynamic relationship between astrocytic processes and dendritic spines in the mouse cortex in vivo, using 2-photon microscopy and a thinned-skull window. In parallel, I will perform an in vitro screen for astrocytic proteins involved in mediating physical contact with the synapse, by using unique subcellular fractionation techniques combined with mass-spectrometry. Finally, identified proteins will be knocked down with silencing RNA to study their role in astrocyte-synapse interactions in situ.This project will generate fundamental knowledge on how astrocytes infl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Utilising innovative rotary kiln technology to recycle waste into synthetic aggregate' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This proposal, which was prepared with the help of an exploratory award which incluced a research feasibility study, is specifically aimed at using an innovative design of rotary kiln to provide a solution to two modem day dilemmas which confront both disposers of waste & users of natural aggregate for the production of concrete: 1. how to overcome the conflicting problems of dealing with the increasing amounts of domestic & industrial wastes &, at the same time, effect a reduction in the numbers of landfill sites being used for disposal 2. how to limit the use of irreplaceable natural resources & still satisfy the growing demand for aggregate. This innovative design of rotary kiln, which is currently undergoing development by the Prime SME Proposer, Sherwen Engineering Company Ltd, represents startling advances in terms of both operating efficiency & overall cost when compared with the traditional heavyweight, inefficient & expensive rotary kiln alternative. The unique properties of the Trefoil rotary kiln (so called because of its triple lobed internal cross section) make it possible to recycle a much greater range of waste material than is possible with conventional kilns. It presents an economical way of combining the thermal & bonding properties of such freely available & often toxic waste as; power station ash; household waste; sewage sludge; river & marine silts; quarry & mine tailings; construction waste & the residue of paper & cardboard production to create synthetic aggregate. A pilot trefoil plant at the Prime SME Proposer's Darford headquarters has already demonstrated its ability to produce synthetic aggregate from a variety of waste. Indications are that a full scale plant will be capable of producing 250,000 cubic metres of synthetic aggregate annually f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unveiling the Role of T-Lymphocyte Clonal Hematopoiesis in Antitumor Immunity to Transform Cancer Immunotherapy' (2021-2027).

assistant: **Concept**

Cancer remains a global health crisis, with over 19 million new cases and 10 million deaths annually. Despite recent success, the efficacy of immunotherapies to treat solid tumors is still limited. T-lymphocytes, central to adaptive immunity, are key players in immunotherapy, yet their genetic heterogeneity and ability to infiltrate and respond effectively to tumors in treatment-naïve and treated patients remains poorly understood. This gap in knowledge presents a significant challenge to advancing cancer immunotherapy.The main hypothesis of tL-CHANCER is that naturally occurring somatic mutations in T-lymphocyte expanded clones, known as T-Lymphocyte Clonal Hematopoiesis (tL-CH), enhance anti-tumor activity, offering a new approach to cancer treatment. By systematically investigating tL-CH mutations in cancer patients, I aim to uncover for the first time their impact on T-cell function, solid tumor infiltration dynamics, and anti-tumor immunity. My approach is original because it explores the uncharted landscape of tL-CH variants, rather than focusing on known T-cell mechanisms. Now is the ideal time to pursue this due to recent advancements in DNA sequencing and the growing recognition of the role of T-lymphocytes in cancer immunity. The project will leverage large-scale genomics and advanced analytical techniques to identify and characterize somatic variants in T-cells, providing insights into their functional impact on cancer immunity.tL-CHANCER will revolutionize cancer immunotherapy by enabling the development of precision-engineered T-cell therapies based on tL-CH mutations. This research will advance our understanding of cancer evolution and create new therapeutic strategies, leading to more effective and personalized treatments for solid tumor patients. By inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'EXPERIMENTAL RECONSTRUCTION AND CHARACTERISATION OF LONG-PERIOD HARMONICS WITH APPLICATION TO VOLCANIC HAZARD PREDICTION: THE LABORATORY VOLCANO.'.

assistant: **Innovation**

Europe includes some of the most volcanically active regions on Earth, hosting about 6% of the 600 volcanoes known to have erupted in historical time and, of those, 2-3 are normally in eruption each year. Some 4-5 million people live within sight of an act ive European volcano, and ~10% of the EU population is economically vulnerable. An improved understanding of volcanic mechanisms will directly enhance the quality of life of European citizens, and vulnerable populations worldwide. Seismicity and ground def ormation are the precursory phenomena most frequently seen before eruption, as the Earth's crust is distorted by magma moving to the surface, and as fluids (magma / gas / hydrothermal fluid) move within faulted rock. Final approach to eruption is commonly preceded by accelerating rates in the rate of low magnitude volcano-tectonic (VT) earthquakes and of long-period (LP) events (seismic signals unique to volcanoes and associated with fluid movement). Although the association of LP events with volcanic activ ity is not new, the specific mechanisms for LP generation is poorly understood. This project will, for the first time under in-situ conditions, generate unique, well-constrained laboratory data under simulated volcanic conditions of stress and temperature. By comparing this data to published field monitoring and theoretical data, the project will produce results that will contribute to improved methods for investigating short-term precursors before volcanic eruptions. Using state-of-the-art acoustic emissio n systems, we will record and analyse microseismic events due to fluid movement in a manner analogous to LP events at field scale on a volcanic edifice; this knowledge will then be brought back to the EU for further experimentation and application to model s.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'NANO-OPTICAL MECHANICAL SYSTEMS' in the context of a Seventh Framework call.

assistant: **Objectives**

Nano-optical mechanical actuation based on nanotube-enriched polymeric materials is a much sought-after technology. In this scheme, light sources promote mechanical actuation of the polymeric materials producing a variety of nano–optical mechanical systems such as tactile displays, artificial muscles, and nano-grippers among others. The purpose of the NOMS project is to fabricate microsystems capable of light-induced mechanical actuation. In particular, the team proposes to build a visual-aid tablet for the blind or partially-sighted. Accomplishing this ambitious project requires knowledge of basic and integrating research within the field. It also requires the contribution of expert neuropsychologists to study, in cooperation with end-users, the effectiveness of the tablet both as an assistive tool for the visually impaired and as a research tool in the field of neuropsychology. The consortium is formed by experts in the areas of materials, optics, microsystems, neuropsychology, as well as end users, who will fabricate the first visual aid tablet. This well-balanced team possesses a unique combination of talent to guarantee achievement of the project objectives. The NOMS approach ensures that a solution (photo-actuated nanomaterials) will be provided to a particular problem (fast-refreshed portable visual-aid devices). NOMS will provide tactile screens for the visually impaired to read complex visual representations such as mathematical equations and graphical images. Everyday activities of such individuals will be greatly improved by including these devices in ATMs, personal computers, mobile telephones etc. This project is visionary with respect to some of the mainstream R&D directions, offering European industry a competitive advantage in the assistive technology ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of the fragile X mental retardation protein (FMRP) in dendritic mRNA transport' (FMRP).

assistant: **Concept**

Lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. FMRP is an RNA binding protein thought to be involved in translation efficiency and/or trafficking of certain mRNAs. A subset of mRNAs to which FMRP binds with high affinity has been identified. These FMRP-associated mRNAs contain an intermolecular G quartet structure. In neurons, dendrite mRNAs are involved in local synthesis of proteins in response to synaptic activity and this represents a mechanism for synaptic plasticity. Recently, it has been postulated that FMRP is involved in the selective targeting of specificmRNAs containing a G-quartet structure into dendrites and in particular in the vicinity of the synapse. Time-lapse fluorescent microscopy of FMRl-EGFP-transfected PC12 cells illustrated the trafficking of RNA-containing granules into the neuritis with FMRP as a core constituent. The overall aim of this proposal is to study the role of FMRP in dendrite mRNA transport, isolation and characterization of the in vivo target mRNAs FMRP to obtain knowledge about the physiological function of FMRP which will lead to a better understanding of the pathogenesis of the fragile X syndrome. In addition, further identification of mRNA targets of FMRP, especially those mRNAs involved in normal synaptic activity, provides knowledge about the role offer in synaptic plasticity and memory storage. In general, the results might contribute to knowledge about fundamental processes that influence memory and learning in men. The first objective is to develop novel culture methods to obtain neuropterans from mouse brain tissue. The second objective is to study the trafficking and kinetics of FMRP-EGFP granules in dendrites of transientlytransfected primary h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ENSOCIO-LA: Strategic, Sustainable R&I Cooperation with Latin America (Climate Action, Resource Efficiency and Raw Materials)' in the context of a Seventh Framework call.

assistant: **Objectives**

Bi-regional cooperation between the EU, its Member States and Latin America has focussed on the environment since the 1st EU-LAC Summit in Rio de Janeiro and the creation of the Strategic Partnership in 1999. Within political dialogue and the subsequent EU-LAC summits, the environment has always been a priority, focusing on climate change, sustainability, biodiversity, natural resources and hazards. At the technical level, numerous projects and initiatives have been implemented with EU and Latin American funding focussing on climate change mitigation, loss of biodiversity, natural hazards, desertification, sustainable management of raw materials, and water and waste management, amongst many others. These projects are complemented with development and cooperation projects funded by the EU, as well as research and development projects funded under bilateral EU-LAC schemes or regional environmental initiatives.  However, this results in a wide array of initiatives and projects oriented towards scientific development of specific topics or isolated small scale development projects. This approach misses the opportunity to create a structured exchange that goes beyond purely content issues and which could create a strategic input to the political dialogue.The ENSOCIO-LA project aims at establishing sustainable and integrated research and innovation cooperation between the EU and Latin American in the environment field, concretely in climate change, resource efficiency and raw materials, as well as at improving dissemination and the exploitation of research results in this area by different user groups. This will be achieved through networking and twinning of existing multilateral and bilateral projects funded by different sources, through the development of efficient interacti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DataMall (Behavee) is an open ecosystem for the eCommerce cyberspace' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Executive SummaryData age is here. Every human endeavor is generating data and is influenced by various data inputs. Actual market state of data sources today is “closed, fragmented, private and non-structured”.At HuMaInn, we are committed to make a difference & disrupt this market - we make innovations for People through technology: Human Machine Innovations. We challenge the Digital Advertising paradigm of ineffective business models where companies are charged per view and not per sales transactions. We connect businesses and let them share their verticals to enrich entire value chains. Our technology is based on Open Source and running in Cloud. Its scalability is simplified due to digital platform-based business model, thus entering into new segments and geographic markets is a matter of marginal costs. We are committed to build an open ecosystem for the eCommerce cyberspace, enabling small companies to compete fairly with big players, by building on microsegment anonymized information/data to offer the best possible and relevant offers. We are one of the revolutionary solutions that will impact Digital Economy agenda, via instant understanding of customer behavior. Our algorithm is constantly improved via Machine Learning, with each new transaction and each new segment, the data validity growth exponentially. Our commercial pilot is running as you read this proposal, adding results to the vast database of customers journeys.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INTELLECTUAL ASSET MANAGEMENT FOR RESEARCH AND ENTREPRENEURSHIP' to be submitted under Horizon Europe.

assistant: **Abstract**

The IAM4RE.eu project seeks to redefine entrepreneurship by emphasizing the valorization of intellectual assets (IA) and standardisation in PROs and academic institutions. Despite existing efforts, there remains a significant gap in early-stage support for managing these assets, essential for creating and strengthening spin-offs from research activities. The project aims to support PROs and their spin-offs in aligning their entrepreneurial efforts with key EU guidelines and Codes of Practice.  IAM4RE.eu facilitates a transition from IP management to a broader IA management framework, moving beyond simple commercialization to focus on value creation that can benefit the broader innovation ecosystem. The initiative will focus on capacity-building and the development of modular educational resources, including training suites, a massive open online course (MOOC), and a ""train-the-trainer"" program, aimed at enhancing skills in knowledge valorization and standardization across Europe. The project will also create and support the delivery of practical tools and services to help PROs and AcIs implement these practices effectively and will produce Policy Guidelines for PROs decision-makers supporting the transition towards more effective internal IAM.  All contents will be tested through real-world application in selected PROs to ensure their effectiveness, with the ultimate goal of scaling these practices across Europe.The consortium, comprising leading EU organizations in entrepreneurship, IAM, and standardization, will leverage their collective expertise to design and deliver educational content, services, and policy guidelines.  The IAM4RE.eu project emphasizes long-term sustainability, with strategies in place for the dissemination of its outputs, direct exploitation of