RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart Microrobotic Biopsy: A Leap Forward in Brain Disease Diagnostics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Over 1B people worldwide suffer from brain diseases, including neurodegenerative disorders, cancers, and functional conditions like epilepsy and depression, incurring an annual treatment cost of €1.7T. Specifically in Europe, the cost reached €800B in 2010, increasing each year. Annually, 350k people are diagnosed with primary brain tumours, resulting in 250k deaths. Additionally, brain metastases affect over 1M individuals yearly.Addressing this socio-economic challenge requires precise medical interventions. Current tools in neurosurgery, such as catheters, needles, and electrodes, are limited to straight paths dictated by the initial skull opening, restricting access to critical tumour sites and thus limiting treatment options.Robeaute's microrobotics is transforming robotic surgery by enhancing surgical precision and introducing micro and nano techniques for targeting cells directly, facilitating improved diagnostics and treatments. These microrobots perform intricate 3D movements, allowing unprecedented access to critical areas affected by brain diseases. Unlike traditional passive microrobots, which rely on large coils and cannot perform biopsies, Robeaute is pioneering an active, self-propelled microrobot designed for in vivo intracerebral 3D navigation, leading to 54 patent filings.WIth EIC support, Robeaute aims to conduct First in Human and pivotal clinical trials targeting the brain biopsy market, focusing initially on challenging areas such as paediatric brainstem tumours, recurrent tumours requiring multiple biopsies, primary tumours for comprehensive profiling, and metastases unresponsive to traditional treatments. These specific niches represent a potential market of €0.3B in the US and Europe. The broader biopsy market, valued at €3.67B, is expanding wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of Shigella T3S-dependent modulation of extracellular ATP release and calcium signalling in neutrophil migration' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Shigella invades the intestinal epithelium following injection of type III secretion effectors (T3S) and causes inflammatory, neutrophil-mediated tissue destruction. The host lab has shown that Shigella invasion induces oscillatory Ca2+-signalling and hemichannel-dependent release of ATP, which is a potent immunostimulatory signal.  I propose 1) that ATP release from epithelial cells attracts neutrophils to sites of infection and promotes their activation and 2) that some Shigella T3S effectors counter these effects during early stages of infection, to escape neutrophil-mediated killing.  I will focus on the effector IpgD. I will determine the ability of IpgD to dampen hemichannel opening during Shigella invasion of epithelial cells. By means of 4D live imaging, I will correlate neutrophil migration with wild-type and ipgD mutant Shigella invasion of epithelial cells and formation of ATP gradients. Also, I will test immune functions of neutrophils exposed to extracellular ATP during wild-type and ipgD mutant Shigella invasion. Further, using a transwell chemotaxis assay and 4D live imaging, I will investigate IpgD-mediated inhibition of cytoskeletal dynamics, i.e. migration, in neutrophils. My work will assess the physiological significance of ATP release during Shigella invasion and contribute to define T3S effectors functions other than invasion, i.e. immunomodulation. This may allow to design new therapeutic approaches. Live imaging, work with live pathogens and primary immune cell cultures are new techniques for me. Together with the expertise acquired previously, the training I will receive in the lab of Prof. Philippe Sansonetti will be integral to my carrier studying host-pathogen interaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Securing international IP Rights for Food tech Innovation: Prolonging shelf-life of plant-based products' (2021-2027) under Horizon Europe.

assistant: **Objectives**

DIE FRISCHEMNAUFAKTUR (DFM) is a food tech start-up from Saxony-Anhalt a structural week region in Eastern Germany. The deep tech food start-up was founded by Dr. Jenny Müller in 2017. Our female founder is still full-time operating CEO and leading the company to grow further. DFM specializes in developing ground-breaking food-technology aiming to prolong the shelf-life of plant-based ultra-fresh products like e.g. fresh-cut fruits, salads and drinks. The very short shelf-life of 1-4 days leads to a huge amount of food-waste in private households and retail, as they have to throw away perished products.With its innovation and overall vision of DIE FRISCHEMAUFAKTUR tackles two societal challenges: 1.Reducing and preventing unnecessary food waste and thus efficient use of resources and battling hunger2.Making healthy eating easy and convenientDFM develops production processes to create products, that last far longer than competitive products. The prolongation of shelf-life can be up to factor 30. E.g. DFM developed a process to make fresh-cut pineapple chunks last up to 6 weeks. For this process patents are filed. The best performing product is: fruit and herb infused water.Adding fruit to water is the most natural way to give water a delicious taste – without added sugars, sweeteners or anything. DFM has developed a patented process that solves the short shelf life and offers infused water with 3 months shelf-life. Two patents for the production process of infused water in Germany were already granted. An International PCT patent was filed. Still, in Q1 2022 DFM has to decide for which countries in the world a patent shall be pursued. For each country significant costs of 3-10 TEUR arise. Covering those costs is extremely difficult for a start-up, still having a valid pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A new CCU composite structure with a novel demountable connection towards CO2 sequestration and material recyclability.' under Horizon Europe.

assistant: **Concept**

Carbon Capture and Utilization (CCU) is receiving increasing interest due to the continuously increasing CO2 emission, where one pathway is to mineralize carbon in concrete building material. Compared with Portland cement, reactive magnesia cement (RMC) has the potential advantage of higher CO2 sequestration during early age curing and its service life. Still, the inadequate carbonation depth limits its application. Another approach to reducing carbon emissions is recycling and reusing components in construction. The key to realizing component reuse and concrete material recycling is the proper demountable connection. However, the sudden slippage and labor-consuming problems of bolts were reported and might hinder the popularity of reusable structures.Therefore, this project will introduce hollow natural fibers (HNFs) with large lumens to enhance CO2 penetration and overcome the carbonation depth limitation. The participants will co-develop a mix design of HNF-reinforced RMC-based concrete that achieves a compressive strength of 50 MPa and a one-way carbonation depth of 60 mm. Besides, a novel demountable bolt-wedge system for dowel-based connectors will be proposed to realize excellent mechanical behavior and efficient construction of CCU composite structures. The shear behavior of the demountable connectors with the bolt-wedge system will be investigated by conducting push-out tests and finite element modelling.For the scientific community, the mix design will provide a solution for CCU structures, and the bolt-wedge system may initiate new research on prefabricated and reusable structures. Regarding societal and economic impacts, the proposed CCU composite structure could reduce emissions by CO2 sequestration and lower the net costs of reducing emissions due to the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INdustrialization and the Process of modernity: the ArChaeological Transformation of the rural world (18th-21st c.)' (INPACT), addressing dissemination and exploitation.

assistant: **Impact**

INPACT aims to investigate how the relationship between local communities and their environment changed as rural areas became industrialized, by analysing material evidence from archaeological and environmental perspectives. The project will question the concept of ‘modernity’ as a one-way passage from ‘traditional’ to ‘modern’ societies, in which rural landscapes and societies are seen as passive subjects rather than active agents of change. The project’s basic hypothesis is that the process of industrialization entailed a complex process of transformation of the rural communities involved, with a far-reaching local and material dimension that has thus far been undervalued, but played a key role in creating and reproducing social and gender inequalities and in the transformation of the landscape.  This hypothesis will be tested by applying the theoretical background and research strategies of the Archaeology of Environmental Resources and Archaeology of Architecture, joined through the perspective of Social Archaeology. INPACT will carry out an interdisciplinary analysis which takes as its case study the village of Casaio, Galicia (NW Spain), where three specific areas (a set of common lands; a deserted neighbourhood; and a wolfram mine) will be studied. The project comprises five phases (documentary analyses; extra-site and intra-site fieldwork; ethnographic reconstruction; laboratory analyses, including pollen analyses; and data processing and interpretation). The project will allow to analyse how the process of construction of the local community’s cultural heritage today, and thus offering new tools to enhance their material and immaterial memory. INPACT will be carried out by Dr. Carlos Tejerizo at the Laboratory of Environmental Archaeology and History (LASA), at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Study of optimisation procedures for decreasing the impact of noise around airports II' (1998-2002).

assistant: **Innovation**

The objectives of Sourdine II are:- development and validation of new advanced innovative environmental friendly approach and departure procedures that have a positive impact on safety, capacity, environment and financial aspects.- development of an implementation plan to provide guidance for the migration from the current operational environment to the new procedures.- development of enabling technology to achieve the successful introduction of the selected departure and approach procedures, such as ATC controller tools, automated aircraft-ATC interaction tools and cockpit monitoring tools (e.g.safety nets)- development of a policy tool, enabling the policy makers to visualise and assess, for each new procedures, the relationship between safety, capacity, environment (noise and emissions) and the financial aspects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'In vivo functions of nuclear envelope rupture and antiviral specialization in dendritic cells' (DCBIO) under Horizon 2020.

assistant: **Objectives**

Dendritic cells (DCs) function at the interface between innate and adaptive immunity and have a crucial role in the induction of immune responses. The goal of this project is to uncover the in vivo functions of two novel molecular mechanisms that were recently identified in vitro in DCs. DCs are rapidly activated when DNA is exposed to the cytosol, which can occur in viral infections. Recent work has revealed that DNA is also transiently accessible to the cytosol in migrating DCs due to rupture of the nuclear envelope, and is detected by the cytosolic DNA sensor cGAS. In the first aim of this project we will investigate the immune consequences of nuclear envelope rupture in DCs in vivo. The second aim of this project is to investigate antiviral specialization of DC subsets. Viral infection of DCs impairs their immune functions. Unpublished data has revealed that in humans, the CD141+ DC subset is constitutively resistant to a broad range of enveloped viruses. Resistance was associated with the expression of the GTPase, RAB15. We will investigate the function of RAB15 in DC biology in vivo to study the division of antiviral labor among DC subsets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and testing of a thermic cutting device for stalks of vegetable fruits and flowers', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The aim of this project is to prevent the forming and transmission of viral and fungal infections in European greenhouses by developing a technology for sterile thermo cutting stalks of crops. This technology can be used for harvesting of vegetable fruit and flowers as well as for the removal of leaves. The thermo cutting device must have a high processing rate and be perfumed in a simple, ergonomic and safe manner. An average grower, without any technical skills, must be able to benefit its use. The device has to be very cost effective in this of industry. With this thermo cutting device a grower can:(1) save up to 30% on pesticides costs,(2) increase the process efficiency with 30% by ergonomic design (no RSI),(3) decrease production loss due to viral and fungal infections,(4) slow down the ageing process of harvested crop with a few days. Both growers and the environment will benefit with a successful development of this thermo cutting device.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Landscape-use optimisation with regards of the groundwater resources protection in the mountain hardrock areas'.

assistant: **Objectives**

Problems to be solvedThe objective of the project is to assess the degree of interference of anthropogenic activities with the hydrosphere in mountain regions. For this purpose, six regions have been selected. Analyses of various factors of agricultural, industrial activities affecting the hydrosphere will permit to assess the efficiency of imposed measures to protect the hydrosphere. The investigation will be carried out on two scales: detailed and regional. This study will also consider the results of monitoring and earlier data filed in archives that would allow to reconstruct the evolution of hydrosphere in studied regions during the last 40 years. The modelling will allow to simulate various alternatives in term of landscape-use leading to an optimum one from the viewpoint of water management.Scientific objectives and approachResults of this work must permit to predict the influences on water (in quantity and in quality) of various landscape-use scenario, in order to give a preference for the choices in land-planning , compatible with a sustainable development. Our project will focus on the following topics:-to identify and solve the correlation between individual factors which influence the quality and volume of water resources in mountain areas.- suggestions for optimum local development from the viewpoint of groundwater protection. Partial output of this work will be the assessment of efficiency of implementation of E.U. and national directives on groundwater protection.- The ultimate objective of the LOWRGREP project is the creation of the ECEMEWAM system (European Centre for Mutual Exchange of Experience in Water management in Mountain Regions) which will lead to a set up of project's own WWW pages. This will provide all data on optimum exploitation from the v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Patient Safety in Robotic Surgery' (SAFROS) targeting Seventh Framework.

assistant: **Abstract**

This proposal addresses the development of technologies for patient safety in robotic surgery. We define patient safety metrics for surgical procedures and then develop methods that abide by safety requirements, formulated in terms of our metrics. We aim at demonstrating that a properly controlled robotic surgery carried out in accordance to our safety criteria can improve the level of patient safety currently achievable by traditional surgery. The main innovative aspects of this project are: 1-\tResearch driven by patient-safety requirements 2-\tEmphasis on methodological rigor: development of a methodology founded in evidence-based medicine 3-\tScope: the entire surgical workflow is considered for development and validation. SAFROS focuses on innovative development of methods for the following technologies: \tSoft organ modeling and calibration, considering patient pathologies and anatomical variants \t Simulation planning in deformable environments\tIntra-operative registration and workflow monitoring\t   Robot modeling and performance monitoring\tSurgeon training\tOperator interface with integrated stereovision and haptics New methods are integrated and validated on two distinct surgical robots (MIRO and RAMS), with respect to two inherently different contexts (pancreatic and vascular surgery). We quantitatively validate the adherence of our methods to the safety criteria, using surgical phantoms and animals. By comparing across robots and surgical contexts we draw conclusions about the generality of our approach. The SAFROS consortium comprises:\tHospitals with worldwide reputation, which provide medical knowledge and can validate our approach\tEurope's leading research groups in telerobotics and surgical robotics \tInnovative companies, to develop new technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rat genome mapping' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The rat is a useful and sometimes unique model for the study of many physiological traits and diseases. In contrast to its central role in physiology, biochemistry, toxicology, transplantation research, cancer research, neurobiology and other fields, the rat has lagged behind the mouse as a genetic model organism. Molecular biology has catalysed the convergence of physiology and genetics, and consequently there is an increasing need for genetic studies in the rat. In the past few years there has been very significant progress in rat genome analysis. While almost no reliable gene assignment was available in the early 80'es, some 600 rat genes have now been assigned to specific chromosomes, and a genetic map with some 650 markers is also available. Teams participating in the present project have been intimately involved in this development, contributing about half of the chromosome assignments and also to the construction of the linkage maps. Furthermore, the participating teams have developed the only existing international rat genetic database (RATMAP). Thus European teams have a strong tradition in rat gene mapping, and our proposal is to generate mapping resources and information necessary to take advantage of the rat for the identification of genes underlying traits relevant to mammalian physiology, behaviour and complex disease, such as diabetes, hypertension, susceptibility to cancer or stress, drug addiction etc. The genetic basis of such traits could be understood if the rat genome was better known. The proposed project contains two parts: mapping the rat genome on the one hand and analysis of multifactorial traits on the other. The mapping work will include: - genetic linkage work of transcribed genes,especially anchored reference loci" for comparative mapping,