RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identifying and validating pre-clinical biomarkers for diagnostics and therapeutics of Neuromuscular Disorders' (BIO-NMD) targeting Seventh Framework.

assistant: **Abstract**

The rapidly expanding knowledge of NMDs genetic diagnosis, pathogenesis and therapeutic possibilities has provided new targets for disease characterisation, early diagnosis, drug discovery and development as well as has raised many questions about how to translate this knowledge into clinical practice as (initial) clinical trials typically run for such a short time that clinical improvement can hardly be expected within that time frame. This militates for the discovery of surrogate endpoints for establishing the efficacy of clinical trials. The concept of biomarkers represents measurable bio-parameters able to flank the process of diagnosis, functional characterisation and therapy in NMDs.OMIC sciences (genomic, transcriptomics, proteomics) offer opportunities to identify biomarkers for finely defining and tuning the NMDs bases. This approach can make available non-invasive biomarkers, to be used for monitoring disease progression, prognosis and drugs response, therefore optimising the choice of appropriate and often personalised therapies. Validated biomarkers will increase therapy efficiency (meaning optimal dose of drug to get responders) and efficacy (responders vs non responders for example if we will identify genomic biomarkers linked to the lack of any therapeutic effect). In this case we could address a truly efficacious therapy (avoiding inefficacious treatment due to unfavourable genomic contexts). The new genomic and proteomic biomarkers discovered within BIO-NMD will be validated both in animal models and in human samples, before entering into a qualification process at the EMEA. The qualified biomarkers resulting from the BIO-NMD project will be ready for ongoing and further clinical trials for the patient benefit. This will increase the therapy efficacy an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular Recognition: Understanding Proteins Adsorption to Inorganic Surfaces' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Understanding how proteins adsorb to inorganic surfaces is important in many biotechnological applications, including the design of medical implants, fabrication of antibacterial surfaces and biomeneralization. Many studies have been carried out in order to examine how proteins interact with inorganic entities or surfaces; still, it is not clear how proteins “sense” the inorganic surface. The aim of the proposed research is get insights into the fundamental rules that govern protein adsorption.The approach will combine the use of two powerful tools: atomic force spectroscopy and self-assembled monolayers. It will undertake a reductionist methodology and study the adsorption of individual amino acids to chemically well-defined surfaces, functionalized with self-assembled monolayers, using single-molecule spectroscopy.The experimental approach that will be developed, in the course of the project, will be useful as a tool for other researches in the field. Additionally, findings from this research will allow the design of antibacterial surfaces, new biomaterials and peptides that interact with inorganic surfaces or particles in a controlled manner to form composite materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamics of the RNAi-mediated antiviral immunity' under Seventh Framework.

assistant: **Concept**

RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that is induced by double-stranded RNA (dsRNA). Double-stranded RNA is commonly generated during viral replication and is considered to be a molecular pattern associated with viral infection. Our previous work demonstrated that viral infections in the fruit fly Drosophila melanogaster are countered by an antiviral RNAi response: the small interfering RNA (siRNA) pathway is the major antiviral defence mechanism in insects. Recently, another RNAi pathway was also suggested to be involved in antiviral defence, the piwi-interacting RNA (piRNA) pathway.The field of insect immunity has been largely dominated by studies on antimicrobial immunity, while antiviral immunity has received relatively little attention. Based on a combination of basic and applied science as well as bioinformatic approaches, we propose to investigate the molecular and cellular aspects underlying the immune dynamics of the antiviral response. We want to uncover fully the mechanism of antiviral RNAi in insects and its main attributes, such as memory, long-lasting immunity, specificity, and effect on the virus.The “nucleic-acid based” immune system that we are deciphering points to the concerted effort of multiple defence pathways from both partners as a new perspective in immunity and host-pathogen relationships.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Congenital heart disease-associated arrhythmia:deciphering Hamamy syndrome, novel rare disease, using iPS cells' to be submitted under Seventh Framework.

assistant: **Abstract**

In the growing population of patients with congenital heart defects (CHD), while arrhythmias are not a major issue for children, they are a leading complication during adulthood. My hypothesis is that the origin of some life-threatening arrhythmias in adult, lies in cardiac structural and electrophysiological development. Thus, studying causes of CHDs may reveal key steps, mis-regulated in adult patients with CHD, leading to arrhythmias.Cardiac development and adult electrical function are finely regulated by transcription factors (TFs). Mutations in TFs have previously been linked to patients with CHD who are developing arrhythmias in adulthood. Hamamy syndrome is a newly described rare disease with CHD and rhythm disorders, caused by a mutation in IRX5 TF. In adult mice, Irx5 is known to regulate cardiac electrical function.I hypothesize that IRX5 mutation in Hamamy-affected patients, leads to misregulation of heart development, promoting arrhythmic events during adulthood.I already generated induced pluripotent stem (iPS) cells from Hamamy patients and a transgenic mouse expressing the Irx5 mutation.The project will be focused on three aims: 1. Characterizing the cardiac cellular function altered by IRX5 mutation, using iPS-derived cardiomyocytes; 2. Identifying cardiac structural and electrophysiological defects in the transgenic mouse; 3. Understanding the syndrome’s molecular mechanism.This study will provide immediate insight into understanding fundamental processes by which some arrhythmias in the adult originate in cardiac development. It may also help unveil the mechanism of age-related increase of arrhythmias in the general population. Finally, it will illustrate the ability of human iPS cell technology to model the abnormal functional phenotype of an inherit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Marriage, Migration and Sexuality: African Migrants in Interracial Same-sex Partnerships' in the context of a Horizon 2020 call.

assistant: **Objectives**

In an interconnected world, the introduction of same-sex marriage in many countries has also affected the lives of LGBTI persons outside their territories, even where homosexuality is illegal. Marrying a (same-sex) citizen of these countries entails family migration rights for the non-citizen spouse. The project Marriage, Migration and Sexuality: African Migrants in Interracial Same-sex Partnerships (MARMIGSEX) investigates how same-sex marriage became a new (formal) migration channel for queer Africans and particularly examines same-sex marriage migration from sub-Saharan Africa (Kenya, Ghana) to countries of the Global North (USA, Netherlands). MARMIGSEX is an interdisciplinary research project that offers a novel approach to the study of marriage migration, transnationalism and interracial relations. First, it overcomes the heterosexual bias in the study of marriage migration and focuses on the international mobility of Africans through same-sex marriage. It examines the mobility options and paths of cross-border same-sex couples and whether and how they managed to live together before and after the introduction of same-sex marriage. Second, the project breaks from the convention of limiting study to the perspective of migrant destination countries, by emphasizing the perspective of origin countries. It explores whether and how same-sex marriage migration enables African men and women to achieve social mobility and gain appreciation and respect in Africa. Third, it questions the assumption in migrant assimilation theory that “mixed couples” are indicators of integration and a proof that ethnic and racial boundaries become less important (at least for the partners in these relationships). Hence it investigates the process of racialization of African migrants’ sexualit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fitting maize into cropping systems on acid soils of the tropics' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objectives are as follows:* To develop screening procedures for aluminium (Al) resistance in maize.* To develop screening techniques for phosphorus (P) efficiency in maize.* To select and breed maize cultivars with improved adaptation to acid soils high in Al and low in P.* To evaluate the site specificity of acid soil resistance of maize cultivars.* To improve the in-depth knowledge of the physiological mechanisms responsible for Al resistance and P efficiency in maize.* To screen a larger maize germplasm based on this physiological understanding.* To improve the quantitative understanding of the comparative advantage of the genetic and agronomic approaches to solve the problem of maize production on acid soils.* To develop agronomic techniques for good maize seedling-establishment in acid soils.* To develop a simulation model which allows to predict the performance of a maize seedling in a specific acid soil.Expected OutcomeIt is expected that the project contributes to the development of maize cultivars and accompanying agronomic technologies for natural recource-friendly, sustainable, and economic cultivation of maize on the acid soils of the world with special emphasis on South America.Plant improvementField screening of divers genetic material on acid tropical soils using standardized experimental conditions at several field sites in the tropics, carefully characterized for soil characteristics. Further improvement of quick laboratory screening techniques for Al resistance (root elongation, callose formation, hematoxylin staining) and correlation to field screening.AgronomyLong-term field experiments are established at the tropical sites on acid soils. Factorial treatments comprise 2 lime rates, 2 P rates, 3 organic manure rates, and 3 maize cultivars dif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'HIstory and IMpact of NEUROimaging on SOCIETY'.

assistant: **Innovation**

The development of neuroimaging techniques, such as computed axial tomography (CAT scanning), functional magnetic resonance imaging (fMRI) and positron emission tomography (PET), has been one of the major biomedical achievements of the past hundred years. These techniques allow the in vivo visualisation of the brain and gave new impetus to medicine, neurology, psychiatry, psychology, philosophy, economics and related fields by providing two unprecedented types of insight. Nations worldwide are making unprecedented investments in neuroimaging-related research: key projects include the European Human Brain Project, which is a H2020 FET Flagship Project (started in 2013, $1.2 billion), the US BRAIN Initiative (2013, $1 billion) and the Japanese Brain/MINDS (2014, $310m).Neuroimaging breakthroughs are making history, but the history of neuroimaging needs to be comprehensively assessed and the impact of neuroimaging on our society still needs to be properly defined. These are the key aims of this MSC Action, which is aimed at developing the first interdisciplinary platform worldwide on the history and impact of neuroimaging. Investigating neuroimaging in a historical perspective will fundamentally contribute to an integrated understanding of how neuroimaging has been shaping and is shaping biomedicine, culture and society. A critical history of the ways in which we see and study the brain is also crucial to increase the awareness about past and current research with neuroimaging, to involve the general public in a constructive debate about neuroscientific and societal challenges, and to promote a scientific culture about neuroimaging techniques and their applications.


**Keywords:** Neuroimaging,  neuroscience,  history of neuroscience,  history of neuroimaging,  history of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Aquaculture and coastal economy and social sustainability' (AQCESS) targeting Fifth Framework.

assistant: **Abstract**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe project aims to answer the following three high-level questions:- How does employment in rural communities change with the arrival of aquaculture?- What are the predictions for socio-economic, environmental and biological sustainability resulting from the interactions between aquaculture and fisheries?- What recommendations can be made for coastal resource management in areas where aquaculture and fisheries coexist?To achieve the answers to these questions the following objectives will be pursued.1) Analysis of labour market conditions in selected areas of five European countries, where aquaculture and fisheries coexist in widely different social and biological environments;2) Analysis of the impact on the local economy of aquaculture and fisheries: social and economic circumstances of rural communities given the interaction between aquaculture and fisheries, fluctuations in profitability and demand for products, and changes in regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Radiocarbon constraints for models of C cycling in terrestrial ecosystems: from process understanding to global benchmarking' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The overall goal of 14Constraint is to enhance the availability and use of radiocarbon data as constraints for process-based understanding of the age distribution of carbon in and respired by soils and ecosystems.  Carbon enters ecosystems by a single process, photosynthesis.  It returns by a range of processes that depend on plant allocation and turnover, the efficiency and rate of litter decomposition and the mechanisms stabilizing C in soils. Thus the age distribution of respired CO2 and the age of C residing in plants, litter and soils are diagnostic properties of ecosystems that provide key constraints for testing carbon cycle models.  Radiocarbon, especially the transit of ‘bomb’ 14C created in the 1960s, is a powerful tool for tracing C exchange on decadal to centennial timescales. 14Constraint will assemble a global database of existing radiocarbon data (WP1) and demonstrate how they can constrain and test ecosystem carbon cycle models.  WP2 will fill data gaps and add new data from sites in key biomes that have ancillary data sufficient to construct belowground C and 14C budgets.  These detailed investigations will focus on the role of time lags caused in necromass and fine roots, as well as the dynamics of deep soil C. Spatial extrapolation beyond the WP2 sites will require sampling along global gradients designed to explore the relative roles of mineralogy, vegetation and climate on the age of C in and respired from soil (WP3).  Products of this 14Constraint will include the first publicly available global synthesis of terrestrial 14C data, and will add over 5000 new measurements.  This project is urgently needed before atmospheric 14C levels decline to below 1950 levels as expected in the next decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Study on High Altitude Aircrafts and Airships (HAAS), deployed for specific aeronautical and space applications' (HAAS).

assistant: **Innovation**

The proposed USE HAAS" study objectives aim to examine prospective aeronautical research agenda in HAAS that European deployment of High Altitude Aircraft (HAIRCRAFT) or High Altitude Airship (HAIRSHIP) implies.Especially the main objectives of the pro ject are to develop a EU advanced aeronautical research strategy in the HAAS sector and develop alternative solar-regenerative fuel cells propulsion for aircrafts. A single HAIRCRAFT, like the US "Helios" aircraft, or HAIRSHIP, like the UK "StratSat"airsh ip, based on aviable design and existing technology would have in certain applications excess of higher capacity than satellite and could be capable of dynamic sharing with terrestrial or satellite users.Recently completed experiments with the "Helios" H AIRCRAFT deployed at 20 km altitude show significant advantage in Communications/Mobile Wireless Service. A single HAIRSHIP equipped with relevant sensors could provide Emergency Communications and Disaster Services, National Securityand Intelligence Servi ce, and to Risk Management. The proposed "USE HAAS" study would contribute and provide the European Community with an option to launch significant AeroSpace program of High Altitude Aircrafts and Airships for multiple or specific uses. The proposed study will last 18 months.The structure of the workplan will be based on 5 parts: Part 1: Analysis of the world state of the art including European work done in HAAS aeronautical uses. Part 2: Developing tentative Research Objectives for European Deployment of HAAS with regard to variety of user services, users services, and prepare Potential Aeronautical ResearchProgramme to support developed Objectives. Part 3: Discussion of developed Objectives and Potential Aeronautical Research Program with EU Community t o examine perc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spatially resolved luminescence to date human prehistory in Early and Middle Pleistocene Spain' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Iberian peninsula contains many sites essential to the current understanding of human evolution and population movement, including some of the oldest evidence of hominin occupation in Europe at over a million years ago. However, many of these late Early and Middle Pleistocene sites are challenging to date due to their old age and the scarcity of applicable methods. The main aim of this project is to develop luminescence-based dating tools targeted to such sites, thereby addressing this chronological gap. The S-IRLum project consists of a combination of method development on two complementary luminescence-based dating techniques―infra-red radiofluorescence (IR-RF) and infra-red photoluminescence (IRPL)―at single-grain resolution and their application to three important sites of Early and Middle Pleistocene age in Northern and Southern Spain. Development of an automated spatially resolved analysis through an ultra low-light imaging detection system is the only possibility to isolate grains with appropriate characteristics and avoid contamination by unwanted signal from other minerals. By analysing individual sediment grains, such methods will also be sensitive to natural sediment re-working events, a common occurrence in cave environments, thus increasing the accuracy of resulting ages. The research output will provide (i) an efficient and reproducible analysis pipeline for spatially-resolved luminescence dating and (ii) robust multi-method chronostratigraphies for the three dated sites, providing further insight into the timing of hominin arrival in Spain and the technological developments of these populations, such as the use of fire.


**Keywords:** Geochronology, luminescence dating, human evolution