RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MULTIFUNCTIONAL SELF-HEALING INJECTABLE HYDROGEL FOR CHRONIC WOUND HEALING AND TISSUE REGENERATION' under Horizon Europe.

assistant: **Concept**

Chronic wounds affect over 305 million people worldwide, significantly reducing quality of life, accounting for 2-4% of EU healthcare costs. Current treatments for deep cavity chronic wounds lack a comprehensive strategy to tackle issues including wound reachability, infection control, inflammation reduction, vascularization, tissue regeneration and scalability. INJECTHEAL introduces a ground-breaking multi-functional, green 4D injectable self-healing hydrogel, based on functionalized pectin and gelatin, serving both as a delivery vehicle for therapeutics and a matrix to promote healing through its biomimetic properties and controlled bioresorption. The hydrogel platform includes antibacterial (e.g., octenidine), anti-inflammatory and pro-angiogenic (e.g., Ac2-26 peptide and siRNAs) agents, to provide effective formulations viable for industrial exploitation. Hydrogel properties are tailored by biocompatible poly(epsilon-lysine) dendrons allowing (i) fine tuning of hydrogel crosslinking degree and (ii) versatile bulk functionalization with bioligands to support cell adhesion, migration and angiogenesis. Immune-stealth polymeric microcapsules, embedded in the hydrogel, protect cell-targeted dendrons, loaded with sensitive agents, from enzymatic degradation enabling their controlled, sustained and precise delivery. Preclinical safety and efficacy assessment according to GLP are set with progressive complexity to reproduce human-relevant pathophysiological features of chronic wounds, from ISO standard in-vitro 2D cell trials and antimicrobial assays to novel in-vitro tests in proprietary human-relevant 3D skin models, human wound exudates and in-vivo animal chronic wound models. Scale-up production, business planning, consultation with key notified regulatory agencies and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lithium recovery and battery-grade materials production from European resources' (LiCORNE), addressing dissemination and exploitation.

assistant: **Impact**

LiCORNE aims to establish the first-ever Li supply chain in Europe. The goal is to increase the European Li processing and refining capacity for producing battery-grade chemicals from ores, brines, tailings and off-specification battery cathode materials. This supply chain encompasses five large primary resource owners (including one of the world leader in Li production) having resources of ~7.8 Mt lithium carbonate equivalent (LCE), in which 2.7 Mt LCE are located in Europe. The European primary resources that are considered in LiCORNE would be enough to supply ~3000 GWh of batteries (i.e., ~10 years to the expected 300 GWh/year production capacity in Europe by 2030). Additionally, the value chain includes a cathode manufacturer who will be able to reuse valuable Li, Co and Ni that will be recycled from waste cathode material, and one producer and distributor of battery-grade Li-chemicals. LiCORNE will investigate 14 different groundbreaking technologies that have been selected for their potential to operate at low CAPEX and OPEX, low carbon footprint, flexibility and industrial scalability. Those technologies are led by 8 top R&D centers in Europe to tackle the main bottlenecks in Li processing and recovery. During 2.5 years, R&D partners will investigate those technologies and bring their TRL from 2 to 4. After this phase, and guided by LCA and LCCA, the most promising technologies will be selected for upscaling to TRL5. During this phase a prototype system will be constructed and demonstrated at TRL5 to produce ~1 kg of battery-grade Li-chemicals (i.e., LiOH∙H2O, Li2CO3 or Li-metal) from ores, brines, tailings and waste cathode material, with the recycling of Co and Ni from the latter. Results will be communicated and disseminated to a wide range of stakeholders and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of TREM proteins in inflammatory lung disease' to be submitted under Seventh Framework.

assistant: **Abstract**

• Both asthma and pneumococcal infection independently affect millions of people world-wide causing significant mortality/morbidity and an associated high economic burden. It is indicated that pathogenesis in asthma is due to enhanced bacterial replication and invasiveness in the lung rather than a worsening of asthma itself.• The overall scientific objective is to combine established models of respiratory bacterial infection and house dust mite induced asthma in the mouse. This project is a new approach to identify the molecular mechanisms and the involvement of the novel surface receptor proteins TREM. Airway macrophages of the asthmatic lung will be analysed by high throughput flow cytometry, cell sorting, immunohistochemistry and cytokines measured by ELISA to identify innate immune alterations. It is indicated that the bacterial complications that occur in patients with underlying lung disease are due to an up-regulation of anti-inflammatory TREM-2 or a loss (via secretion) of membrane bound TREM-1. The main aim is to provide the key tools to reduce the severity of bacterial complications in asthma and identify targets for prophylactics/therapeutics.• High level supervision, specific training by experts in the set up of in vivo respiratory infection models, access to state-of-the-art equipment will enhance my position at the forefront of advances in this field. Strong interaction with other international researchers will enable transfer of knowledge and contribute to a sustainable network. The unique opportunity to attend leadership and management courses will allow me to reach scientific maturity and gain independence as a researcher.• This project fulfils all the ERA criteria and will notably contribute to Europe’s Vision 2020. The resultant publications in high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improvement of the research competitiveness in neuroscience at the Ernst Moritz Arndt University of Greifswald' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Neuroscience is the fastest growing area in basic scientific research. Neuroscience is an interdisciplinary field designed to improve our understanding of neural communication mechanisms in health and disease. Treatments, cures, and, above all, knowledge are the possibilities that continue to be discovered through neuroscientific research. The Neuroscience Group at the Medical Faculty of the University of Greifswald promotes interdisciplinary investigations from the level of gene expression in single neurons to imaging of localized regions of the human brain and neurorehabilitation. The Neuroscience Group at the Ernst-Moritz-Arndt University is located in a convergence region, and the paucity of high-tech, expensive equipment for research, the lack of a critical mass of experienced researchers, a reduced level of experience and knowledge of researchers as well as fewer international collaborations with highly competitive groups put severe limitations on the impact of our publications and our capacity to attract research funds from EU programs. Therefore the major aim of this proposal is to redress this balance by (i) stimulating the realization of the full research potential of our Neuroscience Group by acquisition of cutting-edge technology and equipment; (ii) increasing the quality and international impact of our research by cooperation with high profile institutions and  recruitment of experienced researchers; (iii) improving S&T experience and knowledge of researchers by short term and long term trainings with our Strategic Partners and exchange of know-how and experience with the scientific experts; (iv) organization of workshops to facilitate knowledge transfer at international level; (v) plenary meetings; (vi) dissemination and promotional activities. These measu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Promotion and prevention of infection thread development during the colonization of pea nodule tissues by rhizobium' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The infection thread is an intracellular tunnel which develops in the first steps of the nodulation process, through which the invading rhizobia infect the legume roots. Several plant components identified in the lumen of infection threads suggest a role of reactive oxygen species in regulating the rate of colonisation by Rhizobium and in controlling the success of the symbiosis. The purpose of this proposal is to study the role of pea diamine oxidase, an abundant enzyme in legume root tissues, as the potential source of hydrogen peroxide. The objectives are to demonstrate by a combination of approaches involving biochemistry and in situ localisation studies that diamine oxidase is implicated in the oxidative cross-linking of some components of the matrix of infection threads. Reporter-gene fusions and genetic modification of diamine oxidase gene expression will be achieved to investigate the importance of this gene as a regulator of nodule development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Coevolution of bacteria and conjugative plasmids'.

assistant: **Objectives**

Horizontal gene transfer (HGT) is a fundamental process of bacterial evolution, accelerating adaptation to novel environments and providing access to new ecological niches. However, two of the three mechanisms of HGT, transduction and conjugation, both rely on semi-autonomous vectors (lysogenic phages and conjugative plasmids, respectively), creating the potential for coadaptation between microbe and vector. I here focus on conjugative plasmids. These encode their own replication and transfer, and as such are capable of pursuing their own fitness interests, which need not be aligned with those of their bacterial host. My thesis is that bacterial adaptation by conjugation must therefore be viewed as a co-evolutionary, rather than simply an evolutionary process as achieved to date. In this proposal I take an experimental evolution approach to derive an empirically founded understanding of bacteria-plasmid coevolutionary processes. In particular, I focus on the effects (on the pattern and process of bacteria-plasmid coevolution) of ecological variables identified in population models as crucial to the persistence of conjugative plasmids: environmental heterogeneity, spatial structure, and between-species transfer. Drawing on coevolutionary theory, I highlight that the ecological conditions expected to favour plasmid persistence may often drive the breakdown of bacteria-plasmid coadaptation. Additionally, I will determine the consequences of bacteria-plasmid coevolution for the structuring of microbial communities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Speciality and fine chemicals manufacture, SME tools in support of environmental and sustainable systems', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The proposal focuses on the Speciality and Fines sector of the European Chemicals Industry. The 20,000 SMEs operating here represent 94% of all manufacturers and formulators, contributing 157bn pa to European GVA. Following a major review, these SMEs are under increasing pressure to produce, in a sustainable manner, chemical products which are ecologically safe and of low risk to health. In particular, the imminent REACH legislation (Regulation, Evaluation, Authorisation of Chemicals) seeks innovation in t he assessment and categorisation of all chemicals manufactured in Europe in terms of their toxicological and health impacts.However, SME experience tends to revolve around traditional product lines and this group will experience difficulty and high costs in innovating their manufacturing in keeping with the new imperatives. Survival may be threatened, particularly in Speciality and Fines where a large grouping produces a multiplicity of products, all needing attention. Research will be focused here, on the Sustainability issues surrounding REACH. Green Chemistry alternatives will be introduced and innovative supply chain configurations developed around them, offering enhanced approaches to Sustainability.A methodology will be developed to provide support t o SMEs in migrating towards REACH-compliant and Sustainable Futures. It will be the basis of an online, self-help Toolbox incorporating the research knowledge generated above. It will provide an entry point to identify gaps in their current level of preparedness and signpost approaches and tools to enable them to move cost-effectively to the more sustainable supply chains essential for the future. Dissemination and Training will be key aspects of TESS, leading to awareness of the issues and stimulating take -up and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Water loop conditioning concept to improve papermaking competitiveness (WACOPAC)' (WACOPAC).

assistant: **Concept**

Scientific objectives and approach:The participants include two paper mills, five technology suppliers, a research institute and a university. The research organisations operate as a link between the mills and the technology suppliers. Due to dynamic papermaking conditions fresh water consumption is caused for a significant part by product changes and broke. The goal of the project is to investigate enhancement of sustainable management for stock (wood), energy (natural gas and green house effect) and fresh water for different product types by application of a product and process based water treatment concept. In this water conditioning concept end-of pipe is replaced by in-process treatment in the primary loop of the production process. This concept is defined for various products and feedstock and consists of 4 complementary technologies: Fibre selector / remover, Fixed-bed biology, membrane system including a monitoring and control system. In Task 1, the production systems in the participating mills will be examined, and the requirements regarding water system closure will be specified. Task 2 includes development of a dynamic monitoring and control system and to create insight in the dynamic behaviour of the papermaking process. The next phase - operability studies of the several water treatment technologies - is divided into three main tasks (Tasks 3-5). During task 6, the whole treatment concept will be tested on long-term behaviour conditions in the mill. Influences of the obtained water quality will be investigated on product quality and the papermaking production process. In task 7, the results of this project regarding re-design will be adjusted and optimised. This includes revised water balancing, followed by water pinch analysis to localise best economical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TIER2: ENHANCING TRUST, INTEGRITY AND EFFICIENCY IN RESEARCH THROUGH NEXT-LEVEL REPRODUCIBILITY IMPACT PATHWAYS' to be submitted under Horizon Europe.

assistant: **Abstract**

Lack of reproducibility of research results has become a major theme in recent years. As we emerge from the COVID-19 pandemic, economic pressures (increasing scrutiny of research funding) and exposed consequences of lack of societal trust in science make addressing reproducibility of urgent importance. TIER2 does so by selecting 3 broad research areas (social, life and computer sciences) and 2 cross-disciplinary stakeholder groups (research publishers and funders) to systematically investigate reproducibility across contexts. The project starts by thoroughly examining the epistemological, social and technical factors (epistemic diversity) which shape the meanings and implications of reproducibility across contexts. Next, we build a state-of-the-art evidence-base on existing reproducibility interventions, tools and practices, identifying key knowledge gaps. Then TIER2 will use (co-creation) techniques of scenario-planning, backcasting and user-centred design to select, prioritise, design/adapt and implement new tools/practices to enhance reproducibility across contexts. Alignment activities ensure tools are EOSC-interoperable, & capacity-building actions with communities (i.e., Reproducibility Networks) will facilitate awareness, skills and community-uptake. Systematic assessment of the efficacy of interventions across contexts will synthesise knowledge on reproducibility gains and savings. A final roadmap for future reproducibility, including policy recommendations is co-created with stakeholders. Thus, TIER2 will significantly boost knowledge on reproducibility, create tools, engage communities, implement interventions and policy across different contexts to increase re-use and overall quality of research results in the European Research Area and global R&I, and conseq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plotinus against Gnostics: a New Survey' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The PaGaNS project aims to prepare, in 2 years, a new constitution of the text and a new thorough philological commentary to three Plotinian anti-Gnostic treatises (III.8 [30], V.8 [31], V.5 [32]). Since the philological research on Plotinus’ works has been neglected after Henry – Schwyzer’s ed. minor (1982), there is still much scope for philological analysis in the Enneads. It is unavoidable to examine the sources for the reconstruction of Gnostic thought and Plotinus’ polemic fight, e.g. the Nag-Hammadi Coptic texts. Moreover, these three treatises (together with tr. II.9 [33], the critical text and commentary of which have already been prepared) have often been considered part of a single essay (the so-called Großschrift), a suggestion that has found many opponents and certainly needs a fresh analysis. The PaGaNS project will be carried out this way: 1) new collation of the medieval manuscripts; 2) philological analysis of the text; 3) new examination of H.-S.’ textual choices; 4) preparation of a philological commentary explaining all editorial choices and proposing new solutions for all textual issues; 5) new examination of the Großschrift theory; 6) new examination of all Gnostic sources (e.g. the Nag-Hammadi rolls, Irenaeus). PaGaNS project’s outcomes will be two Belles Lettres volumes (Collection Budé, C.U.F), which are intended to be part of a new edition of the entire Plotinian corpus, an international project called Projet Plotin, conceived and led by Prof. J.-M. Narbonne (Univ. Laval, Québec, CA). This multidisciplinary/interdisciplinary project aims to create a research network including all Projet Plotin centers (located in Canada, USA, Brazil, Italy) and the CNRS (part., the Centre Jean Pépin/UPR 76), French host of the project. The PaGaNS project also a