RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart building retrofitting complemented by solar assisted heat pumps integrated within a self-correcting intelligent building energy management system.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Heat4Cool proposes an innovative, efficient and cost-effective solution to optimize the integration of a set of rehabilitation systems in order to meet the net-zero energy standards. The project develops, integrates and demonstrates an easy to install and highly energy efficient solution for building retrofitting that begins from the Heat4Cool advanced decision-making tool (which addresses the building and district characteristics) and leads to the optimal solution combining (1) gas and solar thermally driven adsorption heat pumps, which permits the full integration with existing natural gas boilers to ensure efficient use of current equipment , (2) solar PV assisted DC powered heat pump connected to an advanced modular PCM heat and cold storage system, and (3) energy recovery from sewage water with high performance heat exchangers.This retrofitting solution together with a closer interaction between building monitoring, demand/respond supply match, weather forecast and HVAC activation/control through a Self-Correcting Intelligent Building Energy Management Systems (SCI-BEMS) will save at least 10% of energy consumption.The project will implement four benchmark retrofitting projects in four different European climates to achieve a reduction of at least 20% in energy consumption in a technically, socially, and financially feasible manner and demonstrate a return on investment of 8 years. The Heat4Cool consortium will ensure the maximum replication potential of the Heat4Cool solution by a continuous monitoring of technical and economic barriers during the development and validation phases in order to present the building owners and investors with clear energy and economic evidence of the value of implementing Heat4Cool solution. A detailed business plan will be developed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Biomedical MXenes as cell labeling and tracking platforms'.

assistant: **Concept**

WHY Visualizing, labeling, and tracking cells is critical for advancements in biomedical research, especially in areas like cancer treatment and cell therapy. Over the past two decades, practices for cell labeling strategies have remained unchanged, facing the same critical technological limitation: a lack of versatility. By using a multidisciplinary approach to create MX-tags, a new class of nanomaterials, BIO-MX aims to overcome this limitation to accelerate biomedical discoveries and protect human health.WHAT MX-tags will create an exciting chemical scenario coupled with single-cell mass cytometry (CyTOF), a revolutionary technology in cell biology. Although CyTOF has shaped the current understanding of cellular matter, fundamental needs remain to be addressed to enable new discoveries: 1. To develop universal cell tags that preserve cell functionality, are compatible with all cell types, and integrate seamlessly with advanced single-cell approaches.2. To produce highly abundant chemically versatile tags able to multiplex the information on cells going beyond current limited available chemistries.3. To create sensitive and multi-function imaging tags to label, track, and provide spatial resolution of cells for cancer applications.HOW My ground-breaking idea is based on transforming the chemistry of 2D materials called MXenes to create MX-tags, a new class of multi-modular materials involving the peculiar properties of cell-penetrating peptides and nanobodies that will open new horizons for mass cytometry-based discoveries. My unique expertise in CyTOF, immune cells, and 2D material development will drive the key steps of the project. My hypotheses rely on the future use of MX-tags as labeling, tracking, and multi-imaging tools. BIO-MX will provide transformative appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Orphan Drug for Acanthamoeba Keratitis'.

assistant: **Objectives**

This project will undertake preclinical and clinical research of the Orphan Drug Polihexanide (PHMB).  The main objective is to provide a safe and effective drug for the treatment of the rare ocular disease Acanthamoeba keratitis (AK) tested according to  international regulatory standards. This debilitating infectious disease is caused by a free living protozoan which, in the absence of treatment, can have catastrophic consequences such as severe pain, visual loss and eye enucleation.  There are no approved drugs to treat this disease. After Orphan Drug Designation Protocol Assistance was requested from the European Medicines Agency on our drug development research plan. The proposed protocol incorporates the EMA advice and will include a non-clinical phase, a double-blind placebo controlled Phase I trial and a randomised double-blind, active controlled, parallel groups Phase 3 study (efficacy and safety therapeutic confirmatory study).  The primary deliverables will be: 1) experimental scientific evidence on the quality, safety and efficacy of PHMB to provide the basis for a Marketing Authorisation within 5 years; 2) recommendations aiming to improve clinical practices in the management of AK based on the efficacy and safety evidence.  ODAK is an industry led project mobilising the critical mass of industrial, pharmaceutical and academic expertise. needed to develop and optimise therapeutic approaches to alleviate the severe negative impacts of AK on the health and quality of life of patients.  In particular, through identifying optimal PHMB formulations and recommending the best dose-benefit treatment regimes. ODAK directly contributes to the International Rare Diseases Research Consortium goal towards 200 new therapies. An estimated 95% of the total estimated EU con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatial Perception and Embodied Autonomy Research' (SPEAR).

assistant: **Innovation**

The popular unmanned aerial robot designs are inspired by manned aerial vehicles from the early 20th century. Since the 2000s, quadrotor drones have dominated the small aerial robots domain due to their structural simplicity and agility. Is further development bound to incremental improvements in their design alongside progress in the autonomy stack? We argue that future research cannot focus on incremental or separate steps in drone design and autonomy alone. Despite the outstanding progress in various domains –from control to perception and beyond - conventional multirotor systems are subject to multiple limitations that constrain their utilization envelope. Furthermore, today's designers often need to tailor their robots to a specific task in a particular application domain, which however is particularly time-consuming. Unlike the current practice, we propose a novel approach to change the paradigm in the design process. We depart from the compartmentalized approach of human-engineered designs and investigate the holistic co-synthesis of task-specific flying robot embodiment and autonomy through a synergistic combination of evolutionary algorithms and deep learning for navigation. We aim to show the benefits of breeding unconventional ""bodies"" and ""brains”. Bodies rely on an evolutionary combination of rotary wing components, and soft and rigid elements, whereas brains exploit the latest progress in deep neural networks. This fundamental change in the design procedure offers a unique pathway towards more capable, more resilient, intrinsically safe flying robots. Upon its success, SPEAR will drive the robotics community forward and towards automatically designed and task-optimized flying machines with superior performance.""


**Keywords:** Aerial robots, Embodimen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deep lEarning foRecasting of Induced Seismicity for risK management operations' (DERISK).

assistant: **Concept**

Climate change mitigation requires a fast and efficient transition to clean and sustainable energy production.Enhanced Geothermal Systems (EGS) play a key Climate change mitigation requires a fast and efficient transition to clean and sustainable energy production. In this context, Enhanced Geothermal Systems (EGS) can play a key role in facing this challenge since, with this technology, clean energy production from the Earth's heat is no longer confined to volcanic or hydrothermal regions. Despite this potential, EGS presents society and economy-related problems that need to be solved to ensure operational safety, continuity, and public acceptance of such industrial projects. Induced seismicity is the major obstacle to the development and social acceptance of EGS projects. In the last years, several damaging earthquakes have been associated with EGS, leading to the definitive closure of the involved projects and raising social concerns against this form of energy production. With DERISK we aim to develop new paradigms for induced seismicity analysis, combining the latest available data acquisition technologies, such as distributed acoustic sensing (DAS), with innovative deep-learning techniques. To characterize induced seismicity with unprecedented resolution and accuracy, we want to develop a next-generation data analysis framework combining deep-learning and waveform-based seismic imaging techniques. Our final goal is to produce deep-learning-based enhanced microseismicity catalogs that will be used to test the performance of new induced seismicity forecasting models exploiting the recent research advances in the field of physics-informed machine learning. The techniques developed within DERISK will be tested and validated with high-quality induced seismicity dataset
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Enhancing connectivity Between Research and Policymaking in Sustainable Consumption'.

assistant: **Innovation**

The project “CORPUS - Enhancing Connectivity Between Research and Policymaking in Sustainable Consumption” aims to develop novel approaches to knowledge brokering (KB) between policy-making and research. It will foster evidence-based policy-making at the example of sustainable consumption by applying and testing a combination of online and offline KB methods. It will stimulate community-building across the involved researchers and policy-makers to arrive at a self-sustaining process of knowledge management in sustainable con-sumption policies. The CORPUS Web Platform is to become a central reference point for high quality information and networking among European professionals working with sustainable consumption. It will provide a space for incubating and nurturing knowledge to be shared among researchers and policy-makers through private domain, and scientific results to be disseminated in the public domain, and a transparent, effective interaction (dialogue) between scientists and policy-makers. The Interaction Exercises in three priority areas of sustainable consumption (food, mo-bility, housing) will explore novel modalities of knowledge brokerage through different forms of face-to-face dialogues. They provide specifically tailored arenas for personal exchange, infor-mation provision, and offline community-building. Since community-building is crucial for successful and ongoing knowledge exchange, a sepa-rate work package is dedicated to building of relationships, governing the network, and stimulat-ing engagement of participants. Another work package provides resources for initial fine-tuning and recurrent adaptations of the process and ensures the transferability of the projects results by systematically reflecting the empirical experiences against the background
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Virtual, Physiological and Computational Neuromuscular Models for the Predictive Treatment of Parkinson's\nDisease' (NoTremor).

assistant: **Innovation**

NoTremor aims to provide patient specific computational models of the coupled brain and neuromuscular systems that will be subsequently used to improve the quality of analysis, correlation (of novel and established indicators) and progression of Parkinson's disease. In particular, it aspires to establish the neglected link between brain modelling and neuromuscular systems that will result in a holistic representation of the physiology for PD patients. A significant breakthrough of NoTremor is that these models will not be used for abstract representation of the physiology or as a match between theory and clinical measurements. NoTremor will integrate computational models of the basal ganglia and brainstem into a unique multi-scale parametric computational model that can be subsequently simulated in the NoTremor simulation engine in a physics-based manner. NoTremor will revolutionize research in the pathophysiology of neurodegenerative movement disorders and provide a novel approach for their analysis founded on a solid computational modelling basis that links midbrain degenerations to motor behaviour. The computational models will be quantified and validated through test campaigns with a very large cohort of PD patients. The ultimate challenging use of the NoTremor virtual patient models will be from the one side clinical decision support and from the other side the investigation, virtual prototyping and modeling of the influence of dopamine levels testing of new drugs using virtual patient models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Environment to Physiology: Neuroendocrine Circuits and Genetic Mechanisms that Modulate Ageing and Development' under Seventh Framework.

assistant: **Concept**

We seek to understand how organisms interpret complex environments to generate appropriate changes in their physiology. Specifically, we will focus on how food and temperature affect lifespan and a switch between reproductive growth versus a specialised developmental arrest (dauer) in C. elegans. Extensive work has indicated that the daf-2 insulin-like peptide (ILP) receptor plays a pivotal role in these processes, but key questions remain about how environmental inputs are linked to secretion of relevant ILP ligands. We propose to address these questions using a quantitative approach. We will use new tools to measure and manipulate the activity of neuroendocrine circuits, and exploit new technologies for automated microscopy of live C. elegans. First, we will delineate the neuroendocrine circuit by identifying ILPs, neurons and the type of neurosecretory activity that affects lifespan and dauer development. Second, we will detail how environmental information is transduced, by measuring the magnitude, kinetics and duration of environment-responsive expression of ILPs and other genes in specific neurons. Using gene expression as a new functional readout for neuroendocrine activity, we will determine how environmental, neuronal and genetic inputs regulate the activity of this neuroendocrine circuit. Third, we will address how environmental, neuronal and genetic inputs affect ILP secretion to influence lifespan and development. By combining quantitative analysis of environmental responses, neuroendocrine activity and physiological outcomes, we will determine how environmental inputs are linked to dauer development and lifespan. This integrated in vivo approach is currently only feasible in simple organisms such as C. elegans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Diffusive Droplet Dynamics in multicomponent fluid systems' (DDD) targeting Horizon 2020.

assistant: **Abstract**

Liquid-liquid extraction - the transfer of a solute from one solvent to another - is a core process in chemical technology and analysis. The current challenge is to miniaturise the analyte extraction process and to optimize the extraction recovery and preconcentration factor. Lacking a priori calculations, this is now often done by trial-and-error. However, to control and optimize the extraction processes, it is crucial to quantitatively understand the diffusive droplet dynamics in multicomponent fluid systems. This is essential and urgently needed not only for modern liquid-liquid extraction processes for diagnostics & microanalysis, for droplet microfluidics, or in the paint & coating industry, but on larger scales also in remediation industry, in chemical technology, or in food processing. These applications of droplets governed by diffusion include cases of immersed droplets in the bulk & on a surface, single & multicomponent droplets & solvents, and cases with high droplet number density. In spite of their relevance, multiphase & multicomponent fluid systems with relevant diffusive droplet dynamics are poorly understood.The objective of DDD is a breakthrough: to fill this gap and to come to a quantitative understanding of diffusive droplet dynamics, thus illuminating the fundamental fluid dynamics of diffusive processes of immersed (multicomponent) (surface) droplets on multiple scales. To achieve this objective, we will perform a number of key controlled experiments and numerical simulations for idealized setups on 9 orders of magnitude in length scale, allowing for one-to-one comparison between experiments and numerics/theory. It is now time to bridge the gap from modern fluid dynamics to process-technology, colloidal & interface science, from nano/microscopic an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Catalytic activity Enhanced meChanisms Of TRANSition metal decorated N-doped carbon by precursor acid treatment' (EcoTrans), addressing dissemination and exploitation.

assistant: **Impact**

Among the next-generation of energy technologies, fuel cells and air batteries show great potential to meet our growing energy demands. However, their overall efficiency is severely limited by the sluggish oxygen reduction reaction (ORR) at the cathode. So far, Pt-based materials are regarded as the ideal ORR electrocatalyst in practical applications because of the high catalytic activity and stability. However, the scarcity, high cost, and inferior long-term stability of Pt restrict its widespread application. The development of non-platinum group metals (non-PGM) earth-abundant alternatives with high activity and durability has been considered as a crucial task. A class of materials including transition metals and carbon-based compounds have been reported as the alternative catalysts to Pt for ORR, especially in proton exchange membrane fuel cells. Among them, the low cost electrocatalysts based on M-N (M, transition metal, such as Co, Fe and Ni) with carbon support (M-N-C) are the most studied. However, the relative low catalytic activity limited by the active cites, low catalyst utilization in practical electrodes because of the thick catalyst layer resulting from the high catalyst loading, and poor stability due to the leaching of transitional metals in real operation conditions are still big challenges in both fuel cells and metal-air batteries. In EcoTrans, the main purpose is to establish new knowledge of the enhancement mechanisms on catalytic activities of novel M-N-C catalysts prepared from acidic treated precursors and surface encapsulation by polymerized ionic liquids (ILs), and then based on the understanding to define the structure and synergistic effects between different elements to guide the development of low cost, highly active M-N-C based catalyst e