RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'biomimetic therapeutic hydrogel layers for interaction with corneal tissues'.

assistant: **Innovation**

Design and development of biocompatible and biomimetic polymers, in the form of hydrogels as soft tissue analogues for biomedical applications, especially those related to the cornea such as contact lenses. Synthesis of nanoparticles to encapsulate therapeutically active molecules and development of a hydrogel layer encapsulating the loaded nanoparticles for contact lenses technology improvement.  Development of methods to detect living tissue-biomaterial interactions. The project will encompass synthesis, fabrication, physico-chemical characterization and in vitro testing.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'CHARACTERIZATION OF THE B-CELL-SPECIFIC GENE REGULATORY NETWORK BY GENOME-WIDE IDENTIFICATION OF DIRECT PAX5 TARGET GENES'.

assistant: **Concept**

A complex network of transcription factor interactions controls the process by which B lymphocytes develop from hematopoietic stem cells (HSCs). Pax5 has been identified as the critical transcription factor controlling B cell commitment throughout B lymphopoiesis. These analyses revealed that Pax5 commits early hematopoietic progenitors to the B cell pathway by repressing B-lineage-inappropriate genes and by simultaneously activating B-cell-specific genes. By comprehensive cDNA microarray analysis, 110 Pax5-repressed and 170 Pax5-activated genes have been identified, demonstrating that Pax5 controls a complex regulatory network involved in B cell signaling, adhesion, migration and immune function. The goal of the project proposed here will be to systematically analyze all direct Pax5 target genes in the entire genome during B cell development. Recently, a mouse strain carrying a biotin tag at the C-terminus of Pax5 has been generated. We will use this mouse strain for genome-wide identification of Pax5-binding sites by chromatin precipitation and Solexa 1G ultrahigh-throughput DNA sequencing. Islands of chromatin modifications have been shown to provide an efficient way of identifying active and repressed promoters and cis-regulatory elements. Here we propose to use chromatin immunoprecipitation (ChIP)-sequencing to map the entire mouse genome for Pax5-controlled promoters and cis-regulatory elements. Integration of this information with the identification of Pax5-binding sites will provide us with a genome-wide map of functional Pax5-binding sites, from which a list of all direct target genes of Pax5 during B cell development will be obtained. The project proposed here will constitute an essential piece of a larger group effort, which aims at elucidating the gene regul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The structures of civil society governance in promoting rural development (on the example of East Germany and Ukraine)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The development of rural areas is becoming an increasingly relevant political issue both in East Germany and Ukraine. The effectiveness of rural development policies can be maximised only when they are supported by strong bottom-up (grassroots) initiatives, represented by civil society organisations in rural areas. The idea of the project is to view various methods to promote rural development, involving the use of governments, markets, and civil society organisations, as governance structures differing in their appropriateness for various specific rural development problems.The project will be aimed at determining the comparative effectiveness of these governance structures for promoting rural development, with particular emphasis on the structural types o f civil society governance. The conceptual innovativeness of the project lies therefore in the integration between economics of rural development in transition and the theory of economic organisation.The specific objectives of research are1) theoretical analysis of civil society governance;2) evaluation of the potential of using the civil society governance for rural development purposes in each covered country;3) development of recommendations for action for the key stakeholders of rural development.The major methods to be used include: literature study, case studies of civil society governance in East Germany and Ukraine, surveys, development of spreadsheet tools. The applicant is currently a post-doctoral student at the Institute for Agricultural Economics, Kiev, Ukraine. The realisation of the proposed project at the Institute of Agricultural Development in Central and Eastern Europe (IAMO) in Halle, Germany, will help the applicant to strengthen his competences and enhance his career perspectives, since the prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Host mobility and pathogen virulence in host-pathogen interactions: ecology and evolution' in the context of a Seventh Framework call.

assistant: **Objectives**

Pathogens that spread by contact between hosts are highly dependent on the social and spatial contact network of the host population. For human societies, this contact network has dramatically changed over the last century, for instance because of long-distance air travel. In this project, the effects of changes in host mobility patterns on pathogen dynamics will be explored. In particular, the effect of increased host mobility on pathogen virulence (i.e. pathogen-induced loss of host fitness) will be investigated. This project will use innovative mathematical modelling techniques that merge ecological and evolutionary questions into a common framework. Specifically, the project will consider scenarios where the movements of hosts takes place at several spatial scales, and where changes in host movement patterns can occur.  The project thus fits into the current growing interest for the evolutionary impact of spatial and social structure in ecology.  Ultimately, the project aims at generating testable predictions that can be used to uncover strategies of virulence management that are adapted to the increased mobility of human populations. The results and methods will be applied to meningococcal disease and to an experimental host-parasite system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Doctoral Network on Prognostics and heAlth management of nexT GeneRatiOn drivetraiNs' (PATRON).

assistant: **Concept**

European manufacturing is at the centre of a twin ecological and digital transition, being both driver and subject to these changes. At the same time, manufacturing companies must maintain technological leadership and stay competitive. The size and the complexity of the associated challenges - such as the integration of Artificial Intelligence, the use of industrial data, the transformation into a circular economy and the need for agility and responsiveness - requires pooling of resources and a novel approach of cooperation. The objective of the PATRON project is to develop the next generation of PHM methodologies, algorithms and technologies, so enabling condition monitoring, with the focus on real-time diagnostics and prognostics. This objective will be achieved by having 10 Doctoral Candidates (DCs) working closely and interacting frequently in this inter-disciplinary and multi-disciplinary area. Despite remarkable progresses in health monitoring boosted by new technologies and AI, most approaches still rely on the use of rudimentary HIs defined more than half a century ago. On the other hand the Community of Tribology is working at the micro and the macroscale of the contacts where loads are applied and wear, damage and faults occur. Impressively enough the two communities, Condition Monitoring/Prognostics and Health Management and Tribology, are following separate paths. The proposed PATRON project brings together the two communities and doctoral candidates and experienced specialists from key players in academia and industry across Europe covering different scientific disciplines and industrial stakeholders from a broad range of backgrounds to optimally tackle the challenges ahead. The PATRON Fellows will be trained in innovative PhD topics as well as receiving sp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Utilizing diversity to decipher the role of autophagy in plant-microbe interactions' (DIVERSIPHAGY) targeting Horizon 2020.

assistant: **Abstract**

During the course of evolution, plants have been exposed to a plethora of beneficial and pathogenic microbes. While symbionts are beneficial for the host plant by improving nutrient supply and health, pathogens are reprogramming their host only for their own benefit. At the interface of this interaction proteomes at both sides are highly flexible and require regulated protein turnover. In line with this, our previous work revealed that regulated protein degradation by autophagy is an essential player in plant immunity. Consequently, plant pathogens hijack autophagy during binary interactions though in contrasting manners. However, in a more complete scenario, plants are constantly exposed to different microbes and hence it is crucial to include the microbial diversity into this equation to obtain a holistic picture of the role of autophagy in plant-microbe interactions. The picture is getting even more complex if we look at the cellular diversity on the host side. Thus, DIVERSIPHAGY approaches the role of autophagy through bacterial and cellular diversity on the host side. We aim to address following questions:•Identifying how the bacterial diversity impacts autophagy and vice versa•Determining new bacteria and/or bacterial communities hijacking autophagy•Revealing the autophagy degradome and novel autophagy factors by utilizing autophagy-modulating bacteria•Identifying tissue and cell-type specific modulation of autophagy by diverse bacteria.With DIVERSIPHAGY we will reveal the holistic picture of the role of autophagy in plant-microbe interactions using a mixture of state-of-the-art approaches including metabolomics, proteomics, single-cell transcriptomics and cell-type specific reverse genetic screens. As such DIVERSIPHAGY is the next generation approach to understan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Thermostable enzymes evaluation of determinants for thermostability and function.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Identification and proof of the importance of features for thermostability will be performed. Research in this area will have a large impact on the possibilities to use enzymes in environmental friendly processes allowing expanded use under harsh conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Agricultural Interoperability and Analysis System' (ATLAS).

assistant: **Innovation**

The overall objective of ATLAS is the development of an open digital service platform for agricultural applications and to build up a sustainable ecosystem for innovative data-driven agriculture using the platform. The platform will allow the flexible combination of agricultural machinery, sensor systems and data analysis tools to overcome the problem of lacking interoperability and to enable farmers to increase their productivity in a sustainable way by making use of the most advanced digital technology and data. The platform will define a service architecture providing hardware- and software-interoperability layers which enable the acquisition and sharing of data from a multitude of sensors and the analysis of this data using a multitude of dedicated analysis approaches. The benefits of data driven agriculture will be demonstrated using the ATLAS platform within a multitude of pilot studies. Around these pilot studies, so called ""Innovation Hubs"", a network of end-users, service providers, researchers and policy makers along the agricultural value chain, will be established to exploit the benefits of digital agriculture to a larger audience. Innovative companies will be attracted through seed funding to provide their services through the platform. With the knowledge created from these pilot studies, ATLAS will put significant effort into the definition of the next generation standards for data driven agriculture.""


**Keywords:** interoperability, digital platform, standardization, sensor systems, decision support, machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular mechanisms in the establishment of disease transmission by invertebrate vectors' in the context of a Seventh Framework call.

assistant: **Objectives**

Symbiosis is a major adaptive process allowing bacteria to interact with other organisms to colonise diverse and adverse environments. The genetic mechanisms behind these symbioses are poorly understood despite the fact that some have a major weight on human health and/or welfare. The goal of this project is to investigate the molecular mechanisms involved in monospecific bacterial-host interactions, in particular those occurring between invertebrates and bacteria leading to disease transmission. As a tool, I will use a simple symbiosis model involving Drosophila melanogaster and Pectobacterium carotovorum (formerly Erwinia carotovora), two genetically tractable organisms which will enable the contributions from both the host vector and the bacterial infective agent to be studied. We predict that the genetic determinants of bacterial-host interactions do not differ much and in several cases may rely on a simple genetic basis: the acquisition of a single gene allowing bacteria to colonize the gut of the host. To confirm this hypothesis, we will study the role of EVF (Erwinia virulence factor) in the symbiotic relationship between P. carotovorum and D. melanogaster as well as that of EVF homologues in Photorhabdus luminescens and Xenorhabdus nematophila, both specific nematode symbionts and insect pathogens. In addition, we will dissect the cell-signalling systems, including bacterial quorum sensing, in the insect-borne transmission of P. carotovorum and study the impact of quorum-sensing interference (quorum quenching) in its prevention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Systemic solutions for upscaling of urgent ecosystem restoration for forest related biodiversity and ecosystem services' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

SUPERB pursues the overall goal to create a lasting enabling environment for transformative change towards large-scale forest and forest landscape restoration, which empowers decision makers to take just and informed decisions for restoration of biodiversity, ecosystem services and carbon sequestration in a manner that minimises region specific trade-offs and maximises synergies between ecosystem services. SUPERB develops and synthesises a multidisciplinary, practical, and scientific restoration knowledge basis and makes it publicly available. In 12 large-scale demonstrators across Europe, we will showcase best practices responding to key forest restoration and adaptation challenges on some hundreds of hectares per demo and with the potential for immediate upscaling to over one million hectares in 10-15 years.  For large scale restoration to be successful, many actors from different sectors and disciplines must behave synergistically and in a mutually reinforcing way. We will speed up transformative change and further upscaling through innovative stakeholder involvement across scales to ensure the favorability and uptake of the proposed approaches. A comprehensive multi-language online Forest Ecosystem Restoration Gateway will guide stakeholders to find answers to their restoration questions, advise them on how to deal with barriers and enablers and provide access to easily applicable and comprehensible tools and materials that support restoration, e.g., best practices for forest restoration or the development of scalability plans, a tree species selection application, an innovative funding guide, and much more. The Gateway will also host a restoration Marketplace, where market agents, e.g. potential funders and landowners, can agree on bids for restoration projects. SU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Turbulence in Accretion Disks – New Perspectives' under Horizon 2020.

assistant: **Concept**

The magnetorotational instability (MRI) is the most promising candidate for driving turbulence, resulting in angular momentum transport and accretion in astrophysical disks, and is currently at the forefront of research. Despite enormous progress in the last decade, important issues regarding the numerical convergence, dependence of the sustenance and transport properties of MRI-turbulence on viscous and Ohmic dissipation as well as the nature of MRI–dynamo still remain unresolved. The project, going beyond the state of the art, aims at clarifying these issues by using numerical simulations and a new approach of a detailed analysis of dynamical processes in 3D Fourier space, underlying the turbulence sustenance. This study will provide a deeper insight into the dynamics, not accessible in physical space, as done in previous studies. The project is built on my recent findings in MHD turbulence in shear flows – on the new concepts of shear-induced spectral anisotropy, nonlinear transverse cascade and vital area, which lie at the basis of the sustenance of shear MHD turbulence, whose special case is MRI-turbulence in disks. This is its main originality. I will work under supervision of Prof. M. Pessah, expert in MRI, in the Niels Bohr Institute, which is an ideal place due to vast theoretical and numerical expertise of its staff in astrophysical fluid dynamics, MHD and, particularly, MRI and due to powerful computing resources. I will acquire valuable skills in: numerical methods, parallel computing, modeling of specific aspects of astrophysical fluid dynamics and (non-ideal) MHD, grant writing, etc. through advance training from the group members. This will be coupled with rich outreach/teaching programs to enhance my pedagogical skills. Thanks to the Marie Curie Fellowsh