RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelica library of thermodynamic and transport properties' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

With this proposal, a Modelica library for thermodynamic properties of gases and liquids that are used as working media in aircraft, and an Excel interface to the same functions with plotting capabilities for typical thermodynamic design diagrams (Temperature-Entropy and Enthalpy-Entropy) shall be developed. It is important that the complete temperature and pressure range experienced by aircraft is covered, from -60 deg Celsius to 200 deg Celsius, depending on the fluid. The pressure range depends on the fluid, as an example a range from 150 to 1100 hPa is necessary for air. Currently available model libraries don't cover the complete range.A fixed starting date of August 1st was chosen to align the project with the original planning of the  ITD activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Application of dendrimers in medicine as new detoxication agents' (DENDRIMED).

assistant: **Innovation**

The aim of the proposal is to enable the top-class young researcher from Belarus to work in a new promising branch of knowledge - on the edge of nanotechnology and medicine. It is planned that employment contract for two years will be established. The main idea of the project is studying the possibility to use dendrimers as new detoxication agents.This is an up-to-date issue due to the enhancement of chemical pollution in our environment that increases the risk of the intoxication. Dendrimers are large globular monodisperse polymers. As a result of their unique structure (many end groups on the surface and empty internal cavities) there are attempts to use them as drug carriers.The idea of using them as effective and specific detoxication agents is absolutely new. Toxins can be attached to end groups or incorporate inside the macromolecule. Estimation of dendrimers binding capacity and checking their influence on plasma proteins will be performed to construct detoxication dendrimers.The host institution re presents a high scientific level and large training expertise, is the participant of well established international collaborations networks and is actively present in the dendrimer field from its very beginning. It offers also a rich programme of complementary training.The host institution is in a possession of modern, well-equipped labs with specialised instrumentation, which respond to the needs set by the project. The training in the host institution will be beneficial for fellowship applicant due to compatibility between the project and his research interests. His previous experience will be crucial for the implementation of the project.On the other hand, he will deepen his knowledge and increase his experience by acquaintance of new techniques. The project is wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Solar Fuel Chemistry: Design and Development of Novel Earth-abundant Metal complexes for the Photocatalytic Reduction of Carbon Dioxide'.

assistant: **Innovation**

The world's demand for energy is increasing and is expected to double in the next 50 years. To meet the energy demand, sustainable carbon-neutral energy sources must be exploited. Solar energy is a greatly underutilized sustainable resource. New large-scale, sustainable energy technologies are required to decrease our dependence on fossil fuels and to decrease the anthropogenic production of greenhouse gases. Technologies for the capture, conversion and storage of solar energy, specifically in the form of chemical bonds, will allow us to develop carbon-neutral energy sources.The design and development of CO2 reduction photocatalysts using Earth abundant metals is described. Our targets include the synthesis of ligands capable of absorbing light in the ultraviolet and visible range and coordination of these ligands to earth abundant metal centres, such as Fe, Ni, Mo and W. Photocatalytic testing will be carried out towards the reduction of CO2 to CO. Subsequent modification of the ligands to incorporate a phosphonate tether will allow grafting of the newly designed catalysts to semi-conducting electrode materials. Catalysis will then be carried out in a heterogeneous fashion in aqueous solution rather than in organic solvents. This will make use of water, the world's most abundant proton source for sustainable CO2 reduction. This cathodic half-cell will then be combined with a water-oxidizing anode to form an overall photoelectrochemical cell which will make syngas (H2 and CO) from water and sunlight.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Centre of ExcelleNce for nanophotonicS, advancEd Materials and novel crystal growth-Based technoLogiEs' (ENSEMBLE3) under Horizon 2020.

assistant: **Objectives**

Within the project an extensive, detailed and robust Business Plan will be developed for setting-up of the Centre of Excellence ENSEMBLE3, with focus on the research excellence and innovation performance in the area of crystal growth-based technologies, novel functional materials with innovative electromagnetic properties, and applications in nanophotonics, optoelectronics, telecommunication, medicine, and photovoltaics. The ENSEMBLE3 Centre will build on the best of (i) nanophotonics and medicine-oriented research at the Centre of New Technologies Warsaw University; (ii) research and development in the area of crystal growth and innovation practices at the Institute of Electronic Materials Technology in Warsaw; (iii) technology transfers via the 3C Crystals Sp. z o. o., SME based in Warsaw. ENSEMBLE3 will be created in strong partnership with the leading institutions in the field with complementary expertise: (i) the outstanding Institute of Nanotechnology at the Karlsruhe Institute of Technology, Germany with its research excellence in controlling the flow of light at an unprecedented level utilizing three-dimensional structured materials; (ii) the Department of Basic And Applied Science for Engineering at the Sapienza University of Rome, Italy with its research excellence in the theory and experiment of linear and nonlinear optics; and (iii) the Cooperative Research Center nanoGUNE Consolider, Spain with its excellence in optical near-field nanospectroscopy and nanoscopy, nanomaterials and nanofabrication.ENSEMBLE3 will build on the strengths of Polish science and technology, where historically crystal growth is a very important field, famously developed by prof. Jan Czochralski whose crystal growth method remains the most widely-used technique for manufacturing sing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coevolutionary approach to unlock the transformative potential of nature-based solutions for more inclusive and resilient communities' (COEVOLVERS).

assistant: **Concept**

Nature-based solutions (NBS) are governance techniques and models that directly and cost-effectively benefit both nature and humans. Despite the progress in NBS design and implementation, the socio-political challenge is that NBS are often tailored for the privileged, their design is expert-led, and their implementation hampered by institutional and administrative inertia. NBS have not been able to support a just transformation of habits for sustainability, and fail to incorporate non-human actors or include marginal and vulnerable humans as true beneficiaries of these solutions. COEVOLVERS goes beyond the state of the art by introducing a co-evolutionary approach, which offers a radically new view for NBS design and implementation by looking at NBS at the interface of technological and biological spheres and considering full co-creation as an interplay not only between the stakeholders but also between human and nonhuman actors. To accomplish this, COEVOLVERS explores through seven Living Labs (LL) across Europe the situational and place-based conditions around the socio-politics of NBS design and implementation. The purpose is to alter the socio-ecological conditions to provide governance models and techniques, motivation structures and practices for more inclusive NBS and resilient communities. COEVOLVERS helps develop already existing, incipient, and emerging NBS with local actors by means of participatory and digital transdisciplinary methodologies. COEVOLVERS will support the growth of novel capabilities, entrepreneurship, and renewal capacity for a just transition. COEVOLVERS engages and informs policy- and decisionmakers to ensure their contribution to transformational impacts. We integrate co-created knowledge and preparedness to act with actual governance and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Atomically engineered core-shell OER catalysts from free‐standing oxide membranes' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Major efforts in recent years to develop catalysts for the oxygen evolution reaction (OER) have shown that perovskites and spinels have significant catalytic activity, making them a promising materials class for water-splitting for hydrogen production. However, so far these complex oxides have displayed limited stability, which prevents realizing their potential. This activity-stability dilemma is compounded by the fact that most progress on ‘rational catalyst design and property engineering’ so far has focused on model-catalysts, whereas we lack effective strategies to transfer optimized electrocatalysts into realistic electrode assemblies.In ScrambledOxs I propose to overcome these major challenges through a novel approach based on free-standing, core-shell heterostructure catalysts produced by atomically engineered oxide epitaxy. This core-shell heterostructure concept, which I will implement as epitaxial trilayers, will enable me to engineer (with atomic control) a catalytically active core-layer sandwiched between stabilizing shell-layers that enhance the chemical stability, to thereby address the activity-stability dilemma. Crucially, using recently established delamination techniques, which I will further develop in this project, I aim to ‘peel off’ optimized trilayers into freestanding oxide membranes. This will provide two crucial capabilities. First, I will be able conduct detailed operando characterization of the electrochemical processes to enable a knowledge-driven catalyst design. Second, I will be able to fabricate (scramble) the freestanding oxides into atomically defined, core-shell-like nanoflakes that I will integrate into carbon-based inks, to thereby demonstrate transfer of the optimized electrocatalysts from model-system into real electrode environ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissection of neurogenetic pathways involved in speech and language disorders' in the context of a Sixth Framework call.

assistant: **Objectives**

A significant number of individuals have unexplained difficulties with acquiring normal speech and language, despite adequate intelligence and environmental situation. There is substantial evidence for a genetic origin of these disorders. FOXP2 is the firs t, and to date only, gene which has been involved in a familiar form of speech and language impairment.Although FOXP2 gene variants are unlikely to directly contribute to common forms of language impairment, this gene and its involvement in a severe for m of the disorder gives a novel insight into neural mechanisms contributing to speech and language. Since FOXP2 protein is a transcription factor, an obvious question to address is what are its downstream targets regulated during neuronal development.The aim of this proposal is the identification of the downstream targets of this newly discovered transcription factor in brain tissue. For this purpose, we propose to take a variety of human neuronal-related cell-lines and to generate stable cell-lines in which we can induce over-expression of recombinant FOXP2 in a controlled manner. We will perform expression profiling of these modified cell-lines using micro-arrays to identify genes whose expression differs as a consequence of changes in FOXP2.The most interesting target genes will then be validated by assessing the modification in their level of expression by quantitative RT-PCR, and by studying the activation/repression of their promoter by FOXP2 using luciferase reporter assay. The possible interactions between FOXP2 and other members of the FOXP family will also be studied to assess if the formation of heterodimers modify the expression profile. We expect to identify new genes, which may be involved in neuro-developmental disorders, what will contribute to the unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Active Network Distributed Open Infrastructure Development'.

assistant: **Objectives**

Future networks must support a wide and rapidly evolving range of service types. Future networks must be programmable to provide the required flexibility. This project will prove the feasibility of constructing a managed, scalable, programmable network infrastructure that uses application layer active networking to provide dynamic customisation of services. It will identify key IST requirements and develop innovative solutions to support security, mobility and multicast. An improved active network architecture will be implemented. Flexible and scalable management solutions based on policy driven autonomous agents will be investigated. Wide-area tests of an integrated prototype will prove that the project results offer a coherent deployment option and will identify areas requiring further work.Objectives:The principal objective of this project is to prove the feasibility of providing a managed, scalable, programmable network infrastructure capable of supporting the future needs of the Information Society. This will be based on active networking in the context of the Next Generation Network infrastructure. To fully realise the benefits of an active network infrastructure, a flexible management system is required, combined with a common information model for resources - both processing and network. The management of active networks, the extent to which management information must be shared, and the communication mechanisms required by the management system are currently open research issues.The detailed scientific objectives of the project are to develop innovative solutions to the open research problems identified above, and test the solutions through a combination of implementation experiments and modelling.Work description:This project will use an existing, state of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Smart ICT-solution to cost-efficiently detect atrial fibrillation to Reduce Europe’s burden of Stroke'.

assistant: **Objectives**

Stroke is the second most common cause of death and complex disability, accounting for ~1 million deaths in Europe each year. Total cost of stroke in the EU amounts to €65 billion a year. Main risk factor for stroke is atrial fibrillation (AF), the most common type of sustained cardiac arrhythmia. Early identification of AF can prevent strokes as treatment can be started on time. However, AF is difficult to capture and often not noticed. Classical AF detection methods (electrocardiogram [ECG] and 24 hour-holter-ECG) have less than 20% success rate. Plus these methods are costly and not suitable for routine large-scale screening.   German SME company Preventicus developed a smart ICT solution for accurate and cost-efficient AF screening, aiming to prevent stroke, based on technologies present in a standard smartphone. Its technology is clinically proven in international studies (accuracy: 96%, predictive value: >99%). To ensure wide deployment as structured AF detection program, Preventicus has set-up clinical grade services surrounding its ‘core’ technology, e.g. Telecare service to verify AF suspects, to safeguard timely referral of the screened AF-patients to a cardiologist for AF confirmation and treatment initiation.   The target market is an attractive high volume market (~150-200M end-users in Europe). Preventicus is the first European player in the market (all its competitors are US-based). As such, investments in the company will enhance Europe’s standing in the smart healthcare technologies market vis à vis the USA. Following successful commercialisation in Germany (~170,000 active users and sales to large health insurance companies), Preventicus is now ready to accelerate growth beyond Germany. Funding will allow the company to take the final steps needed for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular dissection of factors controlling flux through pathways' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Plants produce a spectacular number of bioactive natural products which are essential for plant disease resistance, plant growth and development, and which have great commercial potential for human use as e.g. biomedicines. Current engineering approaches by overexpression of biosynthetic genes often results in only low levels of the desired product. This most likely reflects the complexity of the regulatory networks controlling metabolic flux through biosynthetic pathways. An important prerequisite for fully exploiting the potential of metabolic engineering of natural products is to understand the underlying regulatory and homeostatic mechanisms at the molecular level.   Glucosinolates are natural products of the model plant Arabidopsis. The availability of highly advanced bioinformatics and molecular tools combined with extensive mutant collections in Arabidopsis makes the glucosinolate pathway an excellent model system for studying regulation of metabolic flux. Recent advances in glucosinolate research have identified the first transcription factors and shown that flux through the pathway is controlled by not only regulatory proteins but also the last biosynthetic gene in the pathway. State-of-the-art techniques within integrative bioinformatics, protein-protein interaction, transactivation assays, differential transcript and metabolite profiling will be applied to identify novel interacting regulatory partners and to unravel the molecular mechanism by which the biosynthetic gene controls flux.  The project will develop excellent scientific and leadership competences at a high level for a talented young European scientist to build an independent future career in science. The proposed project may provide future biotechnological solutions for engineering the production