RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mutational and Functional Analysis of the Melanoma Genome' in the context of a Seventh Framework call.

assistant: **Objectives**

Cancer is a genetic disease that involves the accumulation of somatic mutations. Comprehensive understanding of the mutations that cause cancer and their functional effects is a critical step towards: a) global understanding of cancer development and tumor phenotypes, b) sub-classification of cancer based on mutational signatures, and c) developing targeted therapies based on mutations in specific tumors.Recent advances in high-throughput genomic technologies provide an unprecedented opportunity to systematically interrogate the cancer genetic landscape. However, although ample genomic sequences are becoming available, so far these have only provided limited information concerning the complexity of the cancer genome. Furthermore, our understanding of the functional effects of identified mutations is hampered by the difficulty in comprehensively assessing their biological and biochemical effects in a physiological manner.I propose to overcome this major challenge in our understanding of cancer genomics by integrating functional and genetic techniques using melanoma as an example. I propose pioneering high-throughput applications of somatic cell knockout technologies to evaluate newly discovered mutations. The tools developed by this proposal will make it possible to decisively determine the function(s) of proteins that are intimately linked to the pathogenesis of cancer. Funding for this project will enable us to demonstrate the feasibility of initiating a larger scale approach to the ongoing identification of a dynamic and evolving cancer interactome. Furthermore, we will analyze 300 melanoma whole exomes, the largest melanoma dataset to date, to: (i) identify new targetable mutations and (ii) determine the roles of synonymous mutations, which have rarely been studied i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CITIZEN AND MULTI-ACTOR CONSULTATION ON HORIZON2020' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

CIMULACT has as a main objective to add to the relevance and accountability of European research and innovation – Horizon 2020 as well as national - by engaging citizens and stakeholders in co-creation of research agendas based on real and validated societal visions, needs and demands. The project will expand the outlook and debate on STI issues, increase scientific literacy in a broad sense, which includes the understanding of the societal role of Science, Technology and innovation (STI), and create shared understanding between scientific stakeholders, policy-makers and citizens. This multi-actor approach will embrace EU28 plus Norway and Switzerland.The CIMULTACT builds on the principle/conviction that the collective intelligence of society gives Europe a competitive advantage, which may be activated to strengthen the relevance of the European science and technology system. By establishing genuine dialogue between citizens, stakeholders, scientists, and policymakers visions and scenarios for the desirable futures will be developed and debated, and transformed into recommendations and suggestions for research and innovation policies and topics. In short, CIMULACT will● Create vision and scenarios that connect societal needs with future expected advances in Science and their impact on technology, society, environment etc. in connection to the grand challenges● Provide concrete input to Horizon 2020 through recommendations and policy options for R&I and simulated calls for the Horizon2020 Work Programmes.● Engage citizens and stakeholders in a highly participatory debate/consultation/process on scenarios for desirable sustainable futures and research● Build capacities in citizen and multi-actor engagement in R&I through development, experimentation, training and assessme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SOPRA-FORTH Partnership for the Development of a Microsecond Ellipsometer' to be submitted under Seventh Framework.

assistant: **Abstract**

The FORTH’s team has recently demonstrated an extremely fast and sensitive ellipsometer, based on the amplification of the ellipsometric angle by multiple reflective passes (at least 100 and as many as a million) at the interface in question. It is able to make senstive measurements on timescales as fast as microseconds (at least), with applications including biosensing, microelectronics, and surface dyanmics. The FORTH research effort will be integrated with a larger research activity funded by an ERC Starting Grant (TRICEPS), which focuses on the development of basic scientific principles of cavity-enhanced metrology. The scientific and technological aim of the project is to investigate the commercial viabilty of the new ellipsometric techniques, and it's use to probe a range of time-dependent surface phenomena, with unprecedented time resolution and sensitivity. The proposed collaboration will be fruitful for both parties for the following reasons: a) The IESL-FORTH team has demonstrated a very promising technique (in the field where SOPRA is a world leader), but lacks experience in commercial instrument development. The research and product development is best done in conjunction with a leading company with experience with similar successful products. b) The new technique will substantially enhance the time-resolution of the classical ellipsometer by orders of magnitude (down to microseconds at least) and nonetheless remain technically simple. It will also be applicable to a new range of research, and will appeal to a wider client base, which of interest to SOPRA. c) IESL-FORTH will benefit from interaction with an industrial partner, by gaining experience in how a product should be developed, and learning about the problems that such development entails. SOPRA will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Insect-repellent coating for food packages' (INSECTBARRIER) under Horizon 2020.

assistant: **Objectives**

More than 4 million packaging units of rice and dry pasta are lost every year as consequence of insect infestations at European level. This problem represents around one third of the complaints received by the food companies. European consumers are highly reluctant to find insects in the food they consumed and therefore a severe control of insect infestations is demanded. One sole infested package has huge economical consequences for food processors and retailers, estimated in €400 million in complaints and €10 million in un-sold products. In addition, the devaluation of the brand, the loss of consumer’s loyalty, and infringement of food safety regulations (EC 178/2002) can be highlighted. INESFLY CORPORATION, S.L. is a company founded in 1997 that has 14 employees and an annual turnover of €1,368,478. It is specialised in the research and production of new and more efficient products to combat all kind of arthropods and pests. INESFLY’s patented a technology based on the microencapsulation of active agents providing a longlasting activity. INSECTBARRIER proposes to transfer this technology from the current applications to the paperboard packaging.With INSECTBARRIER, we aim to launch our products into the food packaging sector by providing a specific coating solution for cardboard packages as those used to store, transport and distributed the packed rice and dry pasta. As a whole, sales of about €19 million are forecast within a five-year period, generating profits of over €2.4 million.During phase 1, a feasibility study including a business plan will be developed. This study will include: (1) a market assessment to confirm INESFLY’s products acceptance in the two food segments considered; (2) a technical assessment to validate our coatings according to paperboard conve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rethinking Employment Law for a world of Algorithmic Management' under Horizon 2020.

assistant: **Concept**

Amidst important debates about the gig economy and the automation of jobs, employment law has paid scant attention to the rise of algorithmic management: the increasingly pervasive reliance on monitoring technology and sophisticated algorithms to measure, control, and sanction workers. This poses a fundamental threat to the legal regulation of our labour markets. Automated management allows the exercise of hitherto impossibly granular employer control. At the same time, however, the absence of clear decisions and traditional management structures appears to disperse responsibility ‘into the cloud’.  How can employment law respond to a world in which automation has not replaced workers—but their bosses? This pioneering project will develop the first systematic account of the challenges and potential of algorithmic management, examine its implications for legal regulation, and develop concrete solutions to avoid harmful path-dependencies. It tackles a risky challenge that goes right to the core of employment law’s existing structures, with technology developing at unprecedented and unpredictable scale.    Looking at a range of jurisdictions across the European Union and beyond, iMANAGE requires the development of novel, interdisciplinary methodology at the intersection of data science and employment law. In articulating the underlying structures of automated management control, it develops a new and positive role for employment law in ensuring algorithmic accountability, and shaping the responsible use of technology in the workplace. This is a challenge we cannot shy away from: both the theoretical foundations of employment law, and its practical operation across different jurisdictions, depend on understanding and regulating the radically different organisation of the wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SERVICES ASSOCIATED TO DIGITALISED CONTENTS OF TISSUES IN BIOBANKS ACROSS EUROPE' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Biobanks are facilities that provide archived human biological samples for their use in health research. They are pools of biologic material and associated health information such as pathologies and treatments, and the materials stored and their associated information are very relevant for research purposes, among others. Biobanks are increasingly digitalising their biologic material (digital images and associated textual information), but ICT power is still underused. Currently, the digital images are usually spread all over different systems stored in different formats, databases and facilities belonging to different institutions. These image collections own a very valuable knowledge in several fields, but the exploitation of this potential requires mechanisms to gather, access, visualize, process, understand and exploit large image collections. BIOPOOL objective is to build a system able to link pools of digital data managed by biobanks (comprised by histological digital images of the biologic material and the data associated to these images) and to develop added value services for the exploitation of this information (data sharing, image visualization, text and image based search queries and advanced functions such as region-of-interest extraction or automated pathology information extraction in certain cancer types). BIOPOOL aims to establish an intelligent biobank network, demonstrating the potential of this data pool for medical research, diagnosis and educational activities. BIOPOOL consortium is composed of an interdisciplinary group of experienced partners with complementary roles, including 3 innovative SMEs, being the main beneficiaries of the project results commercialization. BIOPOOL has a clear route for exploitation and will not only allow SMEs and bioba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Centre of Excellence in IT Science and Technology' (InnoITeam).

assistant: **Innovation**

To address and promote growth in several technological sectors in Lithuania and encourage EU teaming in ICT-related research and innovation, the overall objective of the project is to create a new Centre of Excellence (CoE) in IT Science and Technology for the Internet of Things and Smart Living Systems, which will be referred to as “InnoITeam”. The long-term vision for InnoITeam is to:● Become the leading provider of innovative technologies for IoT and Big Data for the improvement of the growing technological personal and industry needs in Europe;● Consolidate research and development, education and training, and networking and promotion resources activities in Information and Communications Technology (ICT); ● Coordinate, integrate and support research excellence and innovation development in Lithuania, the Baltic Sea region, and Europe;● Support researchers, academics, industry partners and entrepreneurs in the field of ICT, particularly in IoT, to produce innovations beneficial for the society and economy of Lithuania and beyond.To achieve this long-term vision, the CoE will leverage the knowledge, experience and resources of three Lithuanian institutions – KTU, VGTU and SECR- with the support of two advanced EU partners from Sweden – LiU and TII – in four strategic research and innovation (R&D) topics: R&D Topic 1: User interfacing and interaction design approaches for Smart Environments based on IoT;R&D Topic 2: Cybersecurity aspects in the Smart Environments based on IoT;R&D Topic 3: Data analysis and visualization approaches for data intensive IoT environments;R&D Topic 4: Cognitive IoT technologies for Smart Home Environments.This project has the full support of the Lithuanian Government because it fits perfectly with several of the national priorities within t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Stagnation technology for solar thermal systems'.

assistant: **Objectives**

Solar thermal systems with enlarged collector areas for additional solar assisted heating are comming up now on the European market. In the daily practice, however, due to the enlarged collector areas (in relation to the installed hot water storage volume) there are problems with overheating and stagnation during summer time. The aim of the project is the development of collector systems which guarantee a continuous and maintenance-free operation even under stagnation conditions. The approach to find solutions to the stagnation problems will be: 1. Experimental investigations to get a clear and exact understanding of all the steps of the processes that take place when under stagnation conditions the collector fluid evaporates in the collector loop. 2. Different system concepts (with respect to stagnation conditions) will be investigated by means of numerical simulation. The aim is to analyse the stress of the components and the materials (especially the fluid) in the collector loop. 3. Investigation of new control strategies. The aim of the strategies will be to minimise the number of stagnation events. 4. Testing of prototypes of controllers which use the new control strategies. They will be used in existing solar systems and checked on their performance and behaviour under realistic operating conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Holistic Implementation of European thermal treated hard wood in the sector of construction industry and noise protection by sustainable, knowledge-based and value added products.' in the context of a Sixth Framework call.

assistant: **Objectives**

The goal of HOLIWOOD is the development and holistic industrial implementation of thermal treated hard wood.Two product lines are followed: -pre assembled load bearing walls for the construction of eco²building (incl. flooring) -noise protection barrier sy stem With these products the technical and economic breakthrough will be targeted for thermally treated wood exhibiting superior properties in terms of durability and sustainability. By this way, energy and resource consuming materials such as concrete, al uminum and plastics will be replaced. The research and development activities focus on gathering basic know-how concerning the wood properties, paying special attention to statics, acoustics and manufacturing. The usage of Thermowood for load bearing const ruction parts is a technological innovation leading to a broad range of application in the house construction area. The integration into the construction of ecobuildings is a very promising approach for which the need has been expressed by leading architec ts. Beside the excellent properties, the market claims additional functionalities. The interdisciplinary approach of HOLIWOOD therefore additionally aims at the development of functional coatings. These nanocoatings shall base on modular design, offer ecol ogical coloration and inhibition of the wood graying for more than 20 years. For indoor use the focus is on additional functionalities. The strong participation of SMEs demonstrates the importance of the investigated field of research in this traditional i ndustrial sector. The consortium has been established based on an ongoing international project. Additional partners have been included to cover all necessary fields of R&D. Training and demonstration will prepare future costumers for the new products in due
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Clinical validation of NANO-PL: a hydrogel-based formulation of a small molecule for a highly targeted therapy against Glioblastoma Multiforme (GBM)' under Horizon Europe.

assistant: **Concept**

Glioblastoma (GBM) is considered the highest unmet need in oncology. The average life expectancy of GBM patients is 12-18 months, and the 5-year survival rates remain below 7%. Despite the efforts, the available therapy today counts only with a few (ineffective) approved therapies.Using a machine learning algorithm, we have discovered a correlation between a small molecule and an unexplored target in GBM. We have developed a hydrogel-based formulation of the molecule with great safety and efficacy in vivo. Our formulation showed 40% long-term survival in a GBM rat model, with complete tumour eradication after a single dose treatment. NANO-PL is a one-time treatment, applied locally during surgery, which is effective even in GBM cells that are resistant to the standard of care or those involved in recurrence. NANO-PL also showed a synergistic efficacy with temozolomide, standard-of-care. The EIC will enable the clinical validation of NANO-PL, completely unlocking the GBM treatment.


**Keywords:** Glioblastoma, Clinical validation, orphan drug, rare disease, brain cancer, biomaterials, Piperlongumine