RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Targeting SWI/SNF-related chromatin remodelling defects in solid tumours'.

assistant: **Objectives**

Recent large-scale genomic profiling studies have uncovered mutations in the SWI/SNF (SWItch / Sucrose Non-Fermentable) chromatin remodelling complex subunits in 20% of solid tumours. Most of these tumours resist to current therapies. To address this highly unmet medical need, it is crucial to determine how to harness vulnerabilities induced by SWI/SNF defects. Recent evidence shows that SWI/SNF influences the DNA damage response and is involved in shaping tumour immunogenicity. Though, whether there is a link between these observations, and whether the latter may be therapeutically exploited is unknown. Further, the impact of SWI/SNF defects on tumour heterogeneity, a major determinant of resistance to treatment, remains unaddressed. I therefore propose to identify and understand synthetic lethal vulnerabilities associated with two selected SWI/SNF defects of unmet need (PBRM1 and SMARCB1), and to further study how the latter can be exploited to stimulate the anti-tumour immune response. By using hypothesis-testing and -generating approaches including high-throughput screening on in-house developed isogenic and non-isogenic models, I will identify and decipher novel synthetic lethal vulnerabilities associated with PBRM1 and SMARCB1 defects. Molecular biology, high-content imaging and in vivo experiments will be performed to study the effects of drugs that cause synthetic lethality, both on intra-cellular signalling and on anti-tumour immune response. I will further characterise the impact of SMARCB1 defects on tumour heterogeneity using single cell sequencing on preclinical models and human tumour samples. Preclinical data will be integrated with tumour profiling and clinical data, and will guide the development of proof-of-concept clinical studies, as I previously did
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An innovative 3D content generation solution for digital artists' (ArtomatixSuite).

assistant: **Innovation**

The 3D Computer Graphics Industry represents a vibrant €115 billion global opportunity (2016) poised for spectacular growth. By 2022, the 3D Graphics market will represent €282 billion, a 2.5x increase from current levels. Studios creating 3D content are already at the limits of human capacity and are challenged to meet the current market demands. Artomatix revolutionises the way 3D art is created. Instead of designing, say, an intricate brick wall pixel by pixel for use in a video game scene, one could take a photo of a brick wall with their phone and Artomatix will extrapolate the rest, imagining a new ‘virtual’ brick wall. Rather than being the paintbrush, your computer acts as the painter. Instead of being the painter, an artist will become the art director, providing the high level guidance and vision.Artomatix is offering this ‘virtual painter’ as a cloud-based Software-as-a-Service (SaaS) that can increase the industries art asset production capacity from 69 million assets in 2016 to 95 million, and to beyond 236m by 2022.  With that in mind, Artomatix addresses several EU-wide challenges referenced in the following documents, “Unlocking the potential of cultural and creative industries”, “Towards a data-driven economy” and ""Unleashing the potential of cloud computing in Europe”.The 3D Computer Graphics Industry’s annual wages for 3D artists are expected to reach €63.6bn by 2022, up from €25.8bn in 2016, highlighting the strong potential of automated 3D content creation solutions. Based on our feasibility assessment, software development, sales and marketing efforts and our elaborated business plan, subject to obtaining funding for the project, it is our intention to secure a 0.78% market share of the 3D content creation market (~1.3m assets), have 55k 3D artist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genome-wide analysis of signaling pathways in regulation of the interactions between tumor and host cells: applications for cancer therapy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

In addition to oncogenic mutations that act cell-autonomously, tumor cell growth depends on interactions with its microenvironment. Tumor microenvironment consists of cells of hematopoietic and mesenchymal origin, including inflammatory cells, stem and pro genitor cells, fibroblasts, endothelial cells and vascular mural cells. Tumor cell growth is known to depend on the interaction of tumor cells with such stromal cells. For example, growing tumor needs to recruit normal endothelial and vascular mural cells to form its blood vessels. In addition, tumor cells induce stromal cells to secrete factors that contribute to tumor cell growth and invasion. Stromal cell -dependent interactions represent an attractive target for cancer therapy, because normal cells are genetically stable, and would not be expected to develop resistance to therapeutic agents. The development of such therapies is hampered by the fact that the molecular mechanisms behind tumor-stroma interactions are often poorly understood. In summary, th e workplan entails development of novel advanced functional genomics instruments, technologies and methods for methods to study tumor-host interactions in cancer, and to apply these techniques to the identification of molecules and processes in normal cell s which could be targeted by novel anti-cancer therapeutic agents. In addition, we will develop targeted lentiviruses which would allow in vivo delivery of therapeutic agents into tumors. Functional validation of the discovered targets and developed delive ry systems will be performed in vivo models of murine tumor growth and dissemination. The work has significant exploitation potential, and applications for health in the understanding of the molecular mechanisms of tumor-host interactions, and in the treat ment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '15th Conf on Design of Circuits and Integrated Systems (F, Montpellier, 21-24 November 2000)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This is the 15th venue of this conference promoted and supported by the IEEE Circuit and System Society. This important event gives the opportunity to the academic community as well as the industrial actors to meet each other and to discuss hot topics and last developments. The purpose of the conference is to provide a forum to exchange ideas and to show industrial and research results in the microelectronic field. Both universities and companies are invited to participate in the event. All aspects of Microelectronic Design and test are within the scope of the Conference. Well-known experts in the field will give tutorials and keynote address. 135 papers covering all the domains of interest in Microelectronics will be presented.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing the Next Generation of Environmentally-Friendly Floating Wind Farms with  Innovative Technologies and Sustainable Solutions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

FLOATFARM aims to significantly advance the maturity and competitiveness of floating offshore wind (FOW) technology by increasing energy production, achieving significant cost reductions within the design and implementation phases, improving offshore wind value chain and supporting EU companies in this growing sector. Ultimately, FLOATFARM aims to decrease negative environmental impacts on marine life and to enhance the public acceptability of FOW, thereby accelerating the EU energy transition.To this end, a number of critical technologies have been identified as key catalysts. They apply to different conceptual scales, from individual floating offshore wind turbine level (Action 1) to farm level (Action 2) and environmental and socio-economic perspectives (Action 3). Innovations will be introduced into: 1) ROTOR TECHNOLOGY, where innovative rotor designs for improved energy capture will be explored in a co-design approach with innovative control techniques, improved floaters, and a groundbreaking generator concept; 2) MOORING AND ANCHORING, where shared mooring and innovative dynamic cabling will be investigated; 3) WIND FARM CONTROL, where novel control strategies will be exploited to increase the farm power density, and  4) ENVIRONMENTAL IMPACT MITIGATION, where marine noise emissions and impacts on marine species of FOW farms will be addressed, innovative artificial reefs will be pioneered and social acceptance will be studied.To ensure that effective solutions are pursued and TRL5 can be achieved, FLOATFARM adopts a holistic approach that combines innovative designs, experimental demonstration at laboratory scale, modelling with a suite of beyond state-of-the-art numerical tools, and demonstration in a unique open-sea laboratory, where a new 1:7 scale 15MW FOWT wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Role of Complexity in Decision-Making' to be submitted under Horizon Europe.

assistant: **Abstract**

This research proposal investigates the multifaceted role of complexity in decision-making and social preferences through a series of survey experiments. By examining how narrative complexity, task complexity, and social complexity influence individual choices and behaviors, the study aims to uncover the mechanisms by which complexity affects decision-making processes. The experiments will simulate realistic environments, such as online shopping and economic games, to provide empirical insights into how people navigate complex scenarios. The project will specifically explore whether complexity drives individuals towards default and heuristic-based decisions or rather increases noise in decisions, leading to suboptimal choices in either case. Additionally, it will investigate how accountability and narrative framing can mitigate or exacerbate the effects of complexity. By understanding these dynamics, the research aims to provide actionable insights for improving communication strategies, enhancing consumer decision-making environments, and fostering cooperative behaviors in social and economic contexts.


**Keywords:** behavioral economics, experimental economics, complexity,  narratives, decision-making, survey experiments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The role of the miR156-SPL genetic network during land plant evolution: a comparative analysis of sporophyte development in divergent plant lineages'.

assistant: **Objectives**

An ancient divergence in land plant evolution gave rise to the vascular plant (e.g. Arabidopsis) and bryophyte (e.g. moss) groups. Prolonged apical growth is a defining feature of vascular plants and the establishment of elaborate shoot systems with delayed reproductive development enabled their extraordinary evolutionary success. In contrast, mosses undergo transient apical growth prior to rapid reproductive development. In Arabidopsis, the microRNA miR156 represses members of the SPL family of transcription factors that inhibit apical growth and promote developmental transitions. However, the role of the miR156-SPL module in plant evolution remains to determined. SPL genes evolved before plants colonised land, whereas miR156 arose during early plant evolution. It is possible, therefore, that miR156 was a critical innovation in land plant evolution that facilitated the elaboration of vascular plant forms. My Proposal will test this hypothesis by taking a comparative developmental approach. Using gain and loss-of function genetic techniques I will characterise the role of miR156 and SPL genes in moss sporophyte development, specifically, their effects on apical growth and reproductive development. In Arabidopsis, I will test how SPL genes regulate apical growth using reporter genes assays, advanced imaging and genome-wide surveys of SPL-targets. Finally, I will test the importance of intercellular signaling to apical growth in moss and Arabidopsis by blocking connections between cells. This Fellowship will provide training from a world-leading expert in cutting-edge techniques that are critical to my long-term research objectives. It will allow me to extend my research portfolio by asking fundamental biological questions in a new experimental system (moss) within a high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PReparing Introduction to MArket of SKOTI (PRIMASKOTI) - a breakthrough solution for real-time studies of cytoskeletal motors at single-molecule resolution' (PRIMASKOTI).

assistant: **Concept**

The PRIMASKOTI project will prepare the commercialization of SKOTI—the Swiss Knife for Optical Tweezers and Imaging. The scientific instrument SKOTI is designed to measure interactions between single biomolecules with a focus on cytoskeletal molecular machines. SKOTI combines several state-of-the-art microscopy techniques with contact-less mechanical manipulation, so-called optical tweezers. Because of its ultra high stability, SKOTI has its particular strengths in experiments requiring a solid support such as a glass surface.  This requirement is often the case for cytoskeletal motor protein studies.  Since these molecular machines are key to many essential cellular processes such as transport or cell division, being able to study their interactions is an important step towards understanding diseases such as cancer or neurodegeneration. However, due to the highly specialized knowledge necessary to build and operate such instruments, hardly commercially available, single-molecule experiments are difficult. By commercializing SKOTI, we aim to provide a simple-to-access tool which will broaden the scope of applications and users. SKOTI will provide a modular microscope and optical manipulation platform with unprecedented force- and displacement-resolution, ease of operation through motorization and automatization, flexibility, and overall stability of the system. The key idea is to commercialize a complete solution, where the instrument is supplemented with an isolation from the environment, operation and analysis software, specialized probes, service contracts, and kits for experiments that help to minimize preparation times.  This approach will simplify single-molecule experiments, increase throughput, and lower barriers to engage in such studies. In the long term, our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Partisan Prejudice: Origins, Consequences and Remedies in European Multiparty Democracies' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Partisan prejudice exists when citizens hold negative attitudes towards party supporters. Such prejudice is widespread: many people have stereotypical views of and dislike the supporters of certain parties, sometimes amounting to outright partisan hostility.Partisan prejudice is a challenge for liberal democracy. It deepens societal rifts, lowers social trust, weakens the acceptance of elite compromise and leads to discrimination and social ostracism. This challenge is urgent at a time of political division and democratic backsliding. Yet, partisan prejudice is barely studied, particularly in Europe.PARTISAN will provide a novel theoretical framework and rigorous empirical evidence for understanding partisan prejudice, with the ambition of fundamentally altering how voters and parties are studied in multiparty systems. The theoretical framework posits that objective characteristics of party supporters form the basis of partisan stereotypes, but that these linkages are filtered through individual perceptions and moderated by party- and country-level characteristics.Based on this framework, this project will provide ground-breaking evidence on the prevalence and origins of partisan prejudice and assess its political and societal consequences, including for political participation, discrimination and social cohesion. PARTISAN will also provide political and societal actors with evidence on three ways to reduce partisan prejudice: interparty contact, recategorization and social norms.PARTISAN will implement new measurement tools in a new twelve-country survey and in experiments conducted in population-based surveys and in the field. Innovative experimental designs will be used to rigorously assess the origins and consequences of partisan prejudice, as well as potential reme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Climate change and the Insurance Industry'.

assistant: **Objectives**

Recent documents from the Intergovernmental Panel on Climate Change and the UK Stern Review, have argued cogently that governments, industry and agencies should urgently address the scientific, economic and social implications of climate. The insurance industry must start adapting in response to weather and climate risks. Climate and weather forecasting hosts a wide range of scientific and mathematical methods with a heavy computational base. Insurance mathematics is a rich field, developing advanced stochastic and statistical methods within risk theory. The main objective is to bring statisticians, insurance and climate experts together to build a methodological basis for the emerging field of climate change insurance risk. Statistics is a critical part of the project. We will access insurance data from partners and agencies as well as the huge amount of actual and simulated weather and climate data. This gives us the potential to build models and methods of real relevance to decision making in the insurance industry and help inform government and regulators. Work packages include: (i) early warning of losses, (ii) interpretation of climate modelling for risk analysis, (iii) rain and wind losses, (iv) sea temperature risk  (v) concurrent causes for increased loss. A range of mathematical and statistical methods will form the bedrock for the project. They include methods from probabilistic risk theory such as extreme events, methods from climate simulation, especially ensemble simulations, statistical methods such as time series and space-time models and methods from structural and system reliability. The project will attach special importance to training and dissemination. Training is critical in a multidisciplinary project as this. Dissemination is a duty imposed by t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Non-destructive, scalable, smart monitoring of remote cultural treasures' (ARGUS) under Horizon Europe.

assistant: **Objectives**

ARGUS draws on the current challenges in monitoring remote built heritage assets and the current research focus on preventive preservation, and envisions the development of: (a) a novel built heritage digital twin model to support multi-scale/modal data; (b) an advanced digitisation strategy to support the digital twin model; (c) a portable measurements system for non-descructive physical and chemical monitoring based on miniaturised sensors, and sensor composites integration, comprising of ground and aereal components; (d) AI-enabled methods for the modeling and identification (reverse engineer) of threat factors and their impact; (e) AI-powered multimodal data methods for the fusion of (i) remote sensing climate, weather and pollution data with (ii) natural disaster regional statistics, (iii) governmental statistics (ii) on-site acquired measurements; (f) Trustworthy AI decision support methods for the preventive preservation of built heritage. ARGUS’ innovation targets: (a) Researchers/academics: data from the ARGUS monitoring systems, long-term status processed data, the novel multimodal digital twin white paper, multidimensional/modal data visualisations, APIs. (b) Stakeholders/heritage managers/practitioners: real-time monitoring, long-term status analysis, predictive preser¬vation predictions, intervention decision support. (c) Authorities: real-time monitoring, long-term status analysis, predictive preservation strategies. (d) General public: real-time visualisations, crowdsourcing and citizen contribution in preventive preservation, citizens-in-the-loop R&I design with Living Labs and Hackathons.


**Keywords:** non-destructive monitoring, heritage science, remote monitoring, remote heritage, AI in cultural heritage, computational humanities