RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Sustainable light-emitting devices through control of dynamic doping'.

assistant: **Concept**

Artificial illumination is fundamental and ubiquitous in modern society, and the cuArtificial illumination is fundamental and ubiquitous in modern society, and the current large-scale commercialization of more efficient and practical technologies, in the form of LEDs and OLEDs, is therefore important. This development is not only resulting in improved luminaires and displays, but also paving the way for a wide range of applications in, e.g., medtech, security, and communication. However, a growing concern is related to that the fabrication of LEDs and OLEDs consumes large amounts of critical raw materials (CRMs) and energy, and that their recycling is poorly developed and difficult.A novel illumination technology, the light-emitting electrochemical cell (LEC), is in this context interesting, and we and others have recently developed concepts for its material- and energy-efficient and CRM-free printing fabrication and its delivery of efficient emission (although not yet on par with LED/OLED). These combined achievements now pave the way for a timely and important challenge: can the LEC become the first emissive technology that is truly sustainable through its entire lifecycle?We boldly argue that this vision can turn true if we can take control of the defining LEC feature, viz. the dynamic formation of a p-n junction by electrochemical doping. It was recently shown that current LECs suffer from severe quenching of the excitons (the photon precursors formed in the p-n junction) by too-nearby dopants, and we here introduce new insights and methodologies that address this setback through rational design and careful development of new materials. A key task is to tune the mobility of the electronic charge carriers and excitons, through guidelines established by modeling, for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Do Desires, and only Desires, Justify Action? Evaluating a Radical Version of 'Internalism about Reasons'' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

'Internalism about reasons' is the theory that we only have reason to do what satisfies our desires or goals. ('Externalism', by contrast, holds that what we have reason to do need not depend on our desires or goals.)Primary Research Objective: To explore the plausibility and implications of a radical 'austere' version of internalism.Main Research Questions:1. What reasons do we have, according to internalism?2. Does austere internalism imply there are no moral rules?3. Can internalism account for rational choice?4. Is internalism a form of nihilism? The primary research output (and means of achieving the research objectives) will be a book titled 'Austere Reasons'. Towards this goal, the programme will be organised as follows: an initial period of reading and drafting; an intensive period of writing, discussion, and presentation; two short secondments; revisions and rewriting in light of feedback; submission to the press for publication.Main Objectives:1. Train the Experienced Researcher in the long-form evaluation of a philosophical theory.2. Develop the researcher’s transferable skills in research planning, management, and communication.3. Transfer the researcher’s skills in writing shorter critical papers, and knowledge of evaluative indeterminacy, to the host.4. Increase collaboration and career opportunities for the host and researcher, and the reintegration of the latter into Europe.5. Increase public awareness of debates and research concerning reasons.Main Activities:1. Present chapter drafts from the book at internal and international venues, and secondments.2. Publish the book with a major press.3. Supervisory meetings to critique drafts.4. Host international speakers for seminars and masterclasses.5. Supervise PhD students.6. Hold 'clinics' to assist host me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Translational Microbiome Platform' under Horizon Europe.

assistant: **Concept**

Dysbiosis (the imbalance of the microbial community that resides within and upon us) can affect health and represents a risk factor for the genesis and evolution of a plethora of chronic diseases and pathologies. The analysis of the microbiome is necessary to detect, assess and monitor it. Nevertheless, microbiome analysis and its application to the clinical field is very complex, expensive, and time-consuming.We created MICK, the first digital decision support system helping healthcare professionals in integrating microbiome analysis into clinical practice. MICK automated platform analyses microbiome raw data in real-time, with the highest accuracy and translates it into evidence-based analytics, insights, and practical recommendations.MICK allows customers (clinical centres and diagnostics labs) to scale their service offering to patients without any upfront investment,  determining up to 75% cost reduction and faster TAT compared to existing solutions.


**Keywords:** Bioinformatics,Microbiology,biotechnology,ICT,Health,e-Health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Active probing of brain excitability by electrical micro-stimulations for drug discovery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall objective of EXCITATOR is to transfer the methods developed in the F-TRACT ERC project (f-tract.eu) around the concept of active probing of brain states with the industrialization goal to make them applicable for fast drug discovery in animal models. The industrialization process will be prepared in collaboration with Synapcell SAS, a biotechnology company that provides the biopharmaceutical industry with innovative drug discovery programs.EXCITATOR has one scientific objective (O), which requires achieving one proof-of-concept (PoC):• O – Cortical excitability as a read-out for drug screening. Electrodes will be inserted in the cortex and deep brain structures of rodents in control conditions. Under the acute challenge of drugs injected in animals, the changes of oscillatory power and cortical excitability as quantified in responses to micro-stimulations will be monitored. Our main scientific goal is to demonstrate that intracranial EEG (iEEG) responses to micro-stimulations will be more sensitive than standard iEEG power analysis to quantify the effects of drugs.• PoC – Automatised active probing platform for drug screening: For an industrial use, we will need to automatize the iEEG data recording and processing in animal models. In practice, we will transfer the most relevant functionalities of the FTRACT technology that relies on a human database with automatic data processing. Experimentally, some constraints related to small animals will need to be solved, like defining electrode configurations that maximize neural responses and minimize stimulation artefacts. Eventually, we aim at delivering an innovative and fully integrated drug screening platform from iEEG responses to micro-stimulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Senses of Islam: A Cultural History of Perception in the Muslim World'.

assistant: **Objectives**

The aim of SENSIS is to write a cultural history of the senses in Islam, by examining how the senses have been conceptualised, and calibrated, in a variety of Muslim environments. Sensory perception is not only a physical but also a cultural act: how people experience and understand sight, sound, smell, taste, and touch differs according to the historical, geographical, social and intellectual contexts in which perception occurs. Accordingly, this project comprehensively studies the Muslim sensorium, past and present.The topic is timely and important because (1) questions relating to the sensorium inform, and often complicate, intercultural encounters as well as inner-Muslim debates over identity and alterity; (2) there is a critical need to examine the scholarly contention that Islam’s alleged denigration of vision undermines its ability to modernise; and (3) the hackneyed notion that Islam celebrates the senses, as opposed to a disembodied, rationalised West, is likewise in need of a thorough revision. No sustained, comprehensive reflection on these issues exists in current scholarship, whether in historical-critical, text-based Islamic Studies, the field of study in which this project is primarily located, or in any of its cognate disciplines.Researchers in SENSIS (PI, 2 postdocs, 2 PhDs) will study the topic diachronically through the centuries as well as synchronically across diverse traditions of thought in Islam (in five subprojects: epistemology, mysticism, ethics, law, and aesthetics), thereby avoiding a monolithic, essentialising account of Islam’s attitude toward the senses. The project combines textual approaches in Islamic Studies with methods and theories from religious studies, anthropology, and the emerging field of sensory history. Additional financial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bayesian tools for one-dimensional and three-dimensional hadron structure' under Horizon Europe.

assistant: **Concept**

Parton Distribution Functions (PDFs) and Transverse-Momentum-Dependent PDFs (TMDs) encode our knowledge of the nucleon internal structure in terms of their elementary constituents, quarks and gluons. They are determined by means of global analyses of experimental data which require the development of suitable fitting methodologies. PDFs and TMDs represent an important input for precision studies at current and future accelerator facilities. The development of reliable fitting methodologies and their subsequent validation, in order to ensure the soundness of the corresponding results, is therefore a crucial problem in high-energy physics.Thanks to the wealth of new data and fitting methodologies,  the accuracy to which PDFs and TMDs are known is rapidly improving. With the reduction of the uncertainties, an increasing tension has been observed among results from different groups, making the discussion around the determination of faithful uncertainties all the more urgent.This research proposal,  Bayesian tools for one-dimensional and three-dimensional hadron structure (Bayhadron), develops a new methodology based on Bayesian inference and a set of statistical validation tools for PDF and TMD determination. The main goals of Bayhadron are two. 1) The development of a fully Bayesian methodology for PDF determination, providing a valid alternative to the methodologies based on parametric regression currently used within the community, and the release of a first PDF set based on it. 2) The application of validation tools developed within the PDF community to validate the fitting methodologies currently used for TMD determinations and their possible improvement by means of a Bayesian approach. Both goals of Bayhadron concur to a faithful determination of PDF and TMD errors, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Hedgehog morphogen gradient interpretation'.

assistant: **Concept**

The Hedgehog (Hh) pathway is an evolutionarily conserved signal transduction pathway recognized as a key mediator of many fundamental processes in embryonic development. It has also been implicated in a number of human diseases, ranging from different type s of cancer to developmental defects.Hh acts as a morphogen, activating different target genes depending on its extracellular concentration. A central component of the Hh pathway is the Hh receptor Patched (Ptc). Ptc controls the expression of Hh target genes by repressing Smoothened (Smo), an essential transducer of the Hh signal. Hh binding to Ptc abrogates this inhibitory effect, leading to the activation of the pathway.Although Ptc plays a central role in the Hh pathway, it is still not known how it functions, how it represses Smo and how the binding of Hh alleviates this repression. Furthermore, little is know about the mechanism that allows cells to measure and respond to different concentrations of Hh. We have followed a novel experimental approach by expressing constitutively active and inactive forms of the Hh receptor Ptc, in vivo, in the absence of the endogenous receptor and at physiologically relevant levels.This work has led to the demonstration that cells interpret Hh concentration by measuring the ratio of active (unbound to Hh) to inactive (bound to Hh) Ptc, this being the first demonstration that a morphogen gradient is read by comparing the ratio of active to inactive receptor. My future research plans include the characterization of the mechanism that allows the cells to measure the ratio between bound and unbound Ptc.The understanding of the mechanism that allow cells to measure and respond to distinct Hh concentrations is not only relevant during normal development but also for our understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cone snail toxins as therapeutic agents: Decoding biological mechanisms of conotoxin folding' to be submitted under Seventh Framework.

assistant: **Abstract**

Predatory marine cone snails use extraordinarily complex venoms to capture prey. Most of the ~500,000 biologically active venom components are small, disulfide-rich peptides called conotoxins. They target receptors and ion channels of the nervous system with remarkable potency and specificity. Due to their enormous diversity and target specificity, conotoxins have become invaluable tools in molecular pharmacology and as therapeutic agents. However, their chemical synthesis is hampered by multiple disulfide bonds and additional post-translational modifications, which result in low folding yields and accumulation of aggregated or misfolded products. Recently observed differences between in vitro and in vivo synthesis strongly indicate that folding and modification of conotoxins in the endoplasmic reticulum of the venom glandular cells are tightly regulated processes. Understanding mechanisms that govern the proper assembly of conotoxins at a molecular level is a prerequisite for designing more efficient production systems for conotoxins and other disulfide-rich peptides of biological and pharmacological importance.By using next-generation sequencing, bottom-up proteomics, protein-protein interaction and molecular silencing technologies, this study will elucidate crucial pathways for the oxidative folding and modification of conotoxins. These results will be used to develop a cell-based expression system for conotoxins that are difficult or impossible to synthesise chemically, thus providing novel agents for pharmacotherapeutic studies.While our knowledge on the proper folding of larger protein substrates is constantly improving, research into the generation of small, disulfide-containing peptides is a newly emerging field. By bringing together world-leading scientists in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The structure of the very heavy atomic nuclei'.

assistant: **Concept**

The structure of nuclei containing greater than 100 protons will be investigated. Information gained on discrete states in these nuclei will be an important precursor to the achieving the ultimate goal - the discovery of an island of long- lived superheavy" elements."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cognitive Biases - Windows into the Mechanisms underlying Emotional Vulnerability and Resilience' (COGBIAS) targeting Seventh Framework.

assistant: **Abstract**

Every person responds to life's difficulties in different ways. But why do some 'suffer the slings and arrows of outragerous fortune' and other 'take arms against a sea of trouble'. There are those who are vulnerable and fragile, falling prey to anxiety, depression and a range of compulsions that, left unattended, can easily turn into addicitons. Then there are the those who irrespective of what life throws at them, always seem able to cope. Moreover, a small proportion of these resilient people seem to truly flourish. Rather than ""being OK"" they live lives of optimal mental health. Why? The proposed project aims to find some answers to these questions as well as developing straightforward methods to help people boost their own mental wellbeing from whatever the starting point. The project is truly innovative in harnessing recent advances in molecular genetics that allow for the identification of sets of genes that we know influence the development of toxic and protective cognitive biases, and matching this with cutting-edge innovations in cognitive psychology that allow researchers to instill and modify cognitive biases under laboratory conditions. When combined with advances in Internet technology these techniques provide truly exciting possibilities for implementing ""cognitive bias modification"" (CBM) interventions in people's own homes or on their mobile devices. Even without the added benefit of a genetic component this research is likely to make important advances in our understanding of emotional vulnerability and resilience. But, including a genetic component, while challenging, provides the potential to make major and genuine breakthroughs in our ability to enhance human wellbeing""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Algebraic Representations in Computer-Aided Design for complEx Shapes' (ARCADES), addressing dissemination and exploitation.

assistant: **Impact**

ARCADES aims at disrupting the traditional paradigm in Computer-Aided Design (CAD) by exploiting cutting-edge research in mathematics and algorithm design. Geometry is now a critical tool in a large number of key applications; somewhat surprisingly, however, several approaches of the CAD industry are outdated, and 3D geometry processing is becoming increasingly the weak link. This is alarming in sectors where CAD faces new challenges arising from fast point acquisition, big data, and mobile computing, but also in robotics, simulation, animation, fabrication and manufacturing where CAD strives to address crucial societal and market needs. The challenge taken up by ARCADES is to invert the trend of CAD industry lagging behind mathematical breakthroughs and to build the next generation of CAD software based on strong foundations from algebraic geometry, differential geometry, scientific computing, and algorithm design. Our game-changing methods lead to real-time modelers for architectural geometry and visualisation, to isogeometric and design-through-analysis software for shape optimisation, and marine design & hydrodynamics, and to tools for motion design, robot kinematics, path planning, and control of machining tools. One of the Network SMEs estimates that the innovative impact of ARCADES may enable them to get ahead of competition for up to 2 years, thus benefiting about 40% of their customers. The participants span a multidisciplinary and multisectoral spectrum for realising our vision, all being international leaders at various stages of the pipeline. They form an outstanding ecosystem for training the next generation of applied mathematicians, computer scientists and engineers for achieving our scientific breakthroughs, and who are equipped with a double career adva