RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'MINIMIZATION OF TRANSMISSION LOSSES IN REGIONAL POWER SYSTEMS'.

assistant: **Objectives**

The objective of the project is to demonstrate in practice, in two areas of the electric power network of REE in Spain and ENEL in Italy, the possibility to reduce transmission losses by installing a multilevel voltage control system that allows to achieve continuous reactive power and voltage optimisation.Power losses in the high voltage transmission system (400 and 220 kV) of any industrialised country account for 2 to 4 percent of the electric power consumption. This is equivalent to a generating capacity of about 500 to 1000 MW for Spain and 800 to 1600 MW for Italy.These losses can be reduced with existing technology by installing voltage control systems to continuously maintain the real system operating point as close as possible to the theoretically obtained minimum losses operating point. The transmission losses are expected to be reduced at least 4%, equivalent to a capacity of about 20 to 40 MW for Spain and 32 to 64 MW for Italy. In energy terms, the expected savings are at least as high as 8000 to 16000 MWh per year in Spain and 12000 to 24000 MWh in Italy.The proposed system is a hierarchical voltage control system with four control levels. This complete 4-level control system is proposed as the best possible and practical way to implement a real-time losses System minimisation Control System for high voltage transmission systems. It is a complex control system that has an important impact in power system control, security and stability. All these aspects have been already studied and the available solution (deeply studied in the ESPRIT III project EP6165 IMPROVE) guarantees excellent performance by the use of advanced control systems and optimisation control laws.In this project the manufacturing, installation and demonstration tests of the different contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synoptic Precursors for deveLoping Improved Constraints on Extreme Rainfall' (SPLICER) targeting Horizon Europe.

assistant: **Abstract**

Understanding the impact of climate change on extreme rainfall is vital for informed mitigation and adaptation plans. However, climate models struggle to produce realistic rainfall. SPLICER will provide unique insight into the origin of European rainfall errors in climate models and help improve future projections of extreme rainfall. Our approach recognises that localised rainfall extremes are part of a multiscale process, starting with the global mean climate and mediated by synoptic weather precursors. We exploit two main novelties:1) A ‘tiered model’ approach, considering global earth system models, regional models and novel km-scale models (also known as convection-permitting or storm-resolving) in a holistic framework.2) A physically-based decomposition of rainfall drivers, into global, synoptic and local terms.The analysis is supported by the adaptation of tools from the weather forecasting field, which will enable systematic identification and quantification of rainfall precursors in large multi-model datasets.This interdisciplinary proposal will advance a new mindset linking weather, regional climate, and global climate modelling communities together, and build international research links between the networks of the fellow and the host institution. Novel insights into changing local rainfall extremes will be directly communicated to stakeholders and the public, as well as scientific peers, ensuring societal impact.The training goals of SPLICER are intrinsically integrated with research objectives, ensuring the fellow will develop transferable skills and competences (in particular; numerical modeling and stakeholder engagement), promising to improve academic and non-academic employability. The fellow will expand the host institution’s research capacity in under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Printable Organic-Inorganic Transparent Semiconductor Devices' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Europe is targeting a global leadership in the field of printed electronics (PE). This industry is expected to grow to a market size of 47 billion USD by 2018 (Figure 1) with a long-time potential of 300 billion USD by 2030 as estimated by IDTechEx [1,2,48]. The growth rates of the PE industry are expected to be comparable to those of silicon industry in past (inset of Figure 1). This is an ambitious goal for Europe with strong global competition, for example, from Kovio Inc. [54] (US), Nanosolar [53] (US) and Paru Co [50] (Korea). The POINTS project combines the multidisciplinary and complementary competences of top-level European research groups and industries in order to make a significant step towards the above strategic target. For this purpose, the project objectives are set to make break-through advances in the state of the art in terms of new low-temperature printable materials with enhanced performance. This is achieved through combining the best properties of organic and inorganic materials into hybrid structures at both the molecular and at structural-interface level. The POINTS approach is guided by the recent research discoveries of the project partners. Furthermore, expertise of the consortium in cost-efficient mass fabrication processes is coupled to the materials development to obtain optimum performance and processability. Industrial relevancy of the work is assured by selected test structures of industrial interest for ICT applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Delivery of siRNAs to hematopoietic stem cells using nanoparticles', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

RNA interference (RNAi) is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing. Since the discovery that RNAi occurs in mammalian cells, RNAi has emerged as a powerful tool for elucidating gene function and identifying potential drug targets. Harnessing RNAi holds enormous promise for therapeutic use for diseases that have proven difficult to treat with conventional drugs. RNAi can also be exogenously activated either by transducing cells with vectors to express small hairpin RNAs (shRNA) or by introducing already processed short double-stranded RNAs (siRNAs) into the cytoplasm of cells.  To realize the potential of siRNAs for in vivo drug discovery and therapy there is a need to overcome the considerable hurdle of intracellular delivery across the plasma membrane. siRNAs are not taken up into most cells in vitro in the absence of a transfection reagent. For many cells, mixing siRNAs at nanomolar concentrations with a lipid transfection can efficiently induce gene silencing. However, some important cells, including primary lymphocytes and hematopoietic stem cells, remain highly resistant to lipid transfection schemes.We have recently developed nanoparticles that target integrin b7 that is expressed on leukocytes involved in gut inflammation. Using this approach, we revealed cyclin D1 to be a potential anti-inflammatory target in inflammatory bowel diseases. The goal of this proposal is to explore the hypothesis that targeted nanoparticles entrapping siRNAs can be developed to induce in vivo gene silencing in hematopoietic stem cells. Using this strategy, we plan to identify key genes responsible for pluripotent hematopoietic stem cells (pHSC) self-renewal properties. This will provide a powerful technique to investigate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Forecasting conservation needs for endangered fauna:integrating landscape ecology and ethnoecology to predict habitat quality for the kodkod cat (Leopardus guigna) in the Chilean temperate rainforest' under Seventh Framework.

assistant: **Concept**

Habitat loss, alteration and fragmentation represent severe threats to biodiversity globally. Wild cats, which generally require large areas over which to forage, are particularly affected by fragmentation and human-felid conflicts. Whereas considerable research has been directed towards large carnivores, smaller more cryptic species have received comparatively little attention. The kodkod or güiña (Leopardus guigna) is the smallest of the neotropical cats and has one of the most restricted distributions known for felids occupying a narrow strip within south-central Chile and Argentina, the core area of indigenous Mapuche communities. The kodkod is classified as vulnerable by IUCN. Principal threats are habitat loss due to agricultural land use and retribution killing after attacks on poultry. The general aim of the project is to explore how projected future social and economic development of the fragmented and ethnically heterogeneous Araucanía region will affect habitat availability for the kodkod on private lands. An auto-ecological study will use radio-telemetry for the first time in the northern pre-Andean distribution range to assess habitat use, home range and activity patterns. An ethno-ecological study will provide understanding of the human environment context in which the kodkod lives. Through quantitative and qualitative interviews with Mapuche people and other socio-cultural groups of landowners knowledge and attitudes will be explored. Linking the ecological, ethnic and social information with geographic information, future land use scenarios will be modelled. This allows strategies to be identified for mitigating conflicts between the development process and habitat quality, and for the role of the kodkod as a cultural keystone species for use in conserva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Random complexes and the Cohen-Lenstra heuristics'.

assistant: **Objectives**

Graph limit theory is a rapidly developing field of mathematics. Mészáros proposes to use ideas from graph limit theory to answer questions about random simplicial complexes. The motivation for investigating the cokernels of random integral matrices comes from the number theoretic conjectures of Cohen and Lenstra. Mészáros plans to make use of the fact that the questions arising studying the homology of random simplicial complexes are very similar to questions about the cokernels of random integral matrices. Thus, ideas can be transferred from one area to the other. Mészáros also proposes to investigate the expansion properties of random simplicial complexes.Many researchers at the Rényi Institute (the host institute) played a key role in developing graph limit theory and finding applications of this theory in several areas including ergodic theory, group theory, probability theory, statistical physics and computer science. Large part of Mészáros’s past and proposed projects relies on these techniques. Building on the research that he started during his three years at the University of Toronto as a postdoctoral fellow, Mészáros will bring new questions and areas where these techniques can be applied like stochastic topology. Mészáros’s work will not only provide new areas of applications, but hopefully will open new directions in graph limit theory. The arising new topics in graph limit theory can be of great interest to many members of the host institute.The fellowship would provide Mészáros an excellent opportunity for many fruitful collaborations to explore these topics further. He is also looking forward to improving his organization, management and communication skills to become a more well rounded researcher.


**Keywords:** random simplicial complexes, graph limi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation into the Biological Cost and Adaptation of the Host to Antibiotic Resistance on mobile Genetic Elements in Enterococcus species' (BioCHARGE).

assistant: **Concept**

Conjugative transposons (cTns) are mobile genetic elements that mediate the transfer of antibiotic resistance to a wide range of bacteria including enterococci. Preliminary data revealed that the cTns, Tn6000, confer negligible burden or biological cost on enterococcal hosts. Our hypothesis is therefore: cTns have evolved regulatory mechanisms that can minimize their transcription. This leads to minimal biological cost to the host cell and stability of the mobile element within the population, explaining why they persist in bacteria from environments without selective pressure. In addition, we hypothesize that when two or more elements are in the same cell they may recombine to form a single element, again reducing their biological cost and ensuring their propagation. The aims of the project are: to determine if the cTns isolated from E. faecalis affect the fitness of their host and to test the hypothesis that the transcriptional regulation of these mobile elements determines their stability and persistence. Additionally, to determine if different elements can recombine in vivo, potentially forming new, more fit mobile elements and contributing to the evolution of antibiotic resistance development in pathogens. Experimental approach: The stability of the cTns and their recombination potential in enterococci will be assessed in the presence and absence of selective pressure (antibiotics). The absolute and relative fitness of the cTn containing strains will be evaluated and any compensatory mutations in the host will be determined by high throughput sequencing technologies and whole transcriptome shotgun sequencing. Mutagenesis of the regulatory region within the cTns will be carried out to understand the impact on stability of the element and fitness upon the host and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Delivering  European Translational Information & Knowledge Management Services'.

assistant: **Objectives**

Since its inception the IMI has funded over 30 public-private partnership projects. Many of these projects are centered upon data intensive translational research and are employing integrative analysis approaches to achieve their goals. Although a common KM platform for IMI projects was envisioned in the original IMI Strategic Research Agenda it has not yet been implemented. The lack of a common platform has resulted in projects sourcing redundant KM solutions, introducing unnecessary overheads and a substantial risk to the legacy of datasets. The end result is a less than full realization of the potential of IMI to diminish bottlenecks in drug and diagnostic development. ’Delivering eTRIKS’ will address this gap by providing a sustainable, open IMI translational research informatics/KM platform – eTRIKS, and delivering associated support, expertise and services. Development will begin with transMART, an open source KM platform successfully deployed in IMI U-BIOPRED. However, eTRIKS will not end with transMART. The intent is to build a combined KM/analytics platform that can serve as a basis for continued development and ignite the formation of a cohesive informatics/KM community. Support will be provided throughout the life cycle of a translational research project, including business analysis, platform development, hosting support, data curation, and help desk. The process will be overseen by a support, governance and prioritization board. In addition, ‘Delivering eTRIKS’ will curate selected historic data sets and host in the context of active project data to aid data interpretation. A key legacy of the project will be the provision of a long-term data archive on project closure. An active community will be built to incorporate all stakeholders in ongoing and future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Competition in Digital Markets' in the context of a Horizon 2020 call.

assistant: **Objectives**

The advent of digital markets is affecting all economic activities. From how consumers discover and purchase products to how firms connect to consumers and other businesses, from the way workers and firms learn about each other to the way labor itself is organized, digital platforms are creating new opportunities and challenges for individuals, businesses and governments.The tendency for digital platforms to assume a “winner takes all” form, where the market tips to a situation of highly concentrated oligopoly or even monopoly, puts into question whether the forces of free market competition are enough to guarantee that this concentration does not harm consumers and businesses.This proposal describes three empirical projects that will advance the frontier of our understanding of the role of competition in digital markets.1) The Role of Intermediaries in Digital Advertising. This part studies how competition in digital advertising is evolving due to the emergence of intermediaries. Using data on both the links between advertisers and intermediaries and on internet search ad campaigns, it estimates a model of many-to-many matching to examine how advertisers and intermediaries select each other.2) Competition and Defaults in Online Search. This part studies how consumer bias interacts with competition in internet search. Exploiting a public intervention mandating changes to the default settings for search engines on Android smartphones in Europe, it studies how the design of default options impacts search engine market shares, search quality and advertiser behaviour.3) The Price of Privacy in Digital Markets. Competition in digital markets involves combinations of prices and forms of monetization of users’ data. Using data from the smartphone app market, this part estimate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamics of T cell activation and anti-tumor T cell activity in vivo' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The orchestration of an adaptive immune response relies on a succession of dynamic molecular and cellular events taking place in specialized micro-environments. The outcome of T cell responses against viruses or tumors is influenced by contact-dependent in formation exchanges between various lymphocyte subsets and antigen-presenting cells. While studies of lymphocytes removed from their normal environments provide an essential foundation for understanding the cellular responses to different stimuli, a full u nderstanding of lymphocyte biology, however, will require integrating the information obtained from studies of isolated lymphocytes with studies of how the cells behave in their native tissue environments. We propose to use state of the art real-time imagi ng techniques to visualize in live anesthetized animals, the initiation and the regulation of an immune T cell response as it happens. Specifically, intravital multiphoton imaging will be used in combination with other methodology to study four fundamental aspects of T cell biology in lymphoid organs and tumors i) the regulation of cell-cell interactions between T lymphocytes and dendritic cells in lymph nodes ii) the basis of CD4 and CD8 collaboration during T cell responses iii) the mode of action of regu latory T cells, a subset of lymphocytes endowed with the capacity to suppress T cell responses iv) the migration and cytolytic activity of CD8 T cells within established tumors, during spontaneous or induced anti-tumor T cell responses. Elucidating how the various immune cell subsets act together to regulate the outcome of T cell responses in vivo could help identify new means to manipulate the immune system to fight cancer and autoimmune diseases. In addition, our approach should provide a new tool to bett er