RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeted Protein Degradation as a Therapeutic Strategy for the Treatment of Gastrointestinal Stromal Tumour (GIST)' (GIST) under Horizon Europe.

assistant: **Objectives**

Gastrointestinal stromal tumour (GIST) is the most common subtype of sarcoma in humans and its initiation and progression is predominantly driven by constitutively activating mutations in the receptor tyrosine kinase (RTK) KIT. This dependency on KIT led to the approval of kinase inhibitors for the treatment of GIST. Inhibition of KIT activity is effective at treating GIST in the short-term however, the majority of patients eventually develop resistance. This resistance is predominantly due to the emergence of additional KIT mutations.  Therefore, the development of alternative KIT targeting therapies, beyond the current state-of-the-art, is paramount for the effective treatment of GIST in the long-term. One such strategy is targeted protein degradation (TPD). TPD is based on drugs called degraders which are compounds that induce the proximity between a protein of interest (POI)  and components of the cellular proteolytic machinery resulting in the destruction of the former. Degradation of KIT offers several benefits over inhibition, that may combat resistance in GIST. Firstly, small molecule inhibitors rely on a strong affinity for the POI to be effective whereas degraders can maintain activity when the affinity for the target is compromised by mutations. Secondly, inhibition of protein function is not a requirement for degrader activity and therefore additional ligandable sites on the POI. In this project, I will employ a multifaceted drug discovery approach with the overarching aim of designing, identifying, and optimising degraders of KIT and investigate their effectiveness in GIST models. In order to explore the full potential of TPD in the treatment of GIST, I will pursue two different modalities of degraders: (i) bivalent (Objective 1) and (ii) monovalent (Object
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project '‘Till Death Us Do Part’: The Comparative History of Domestic Homicide in Early Modern Europe'.

assistant: **Objectives**

This project offers new complex analysis of the history of private violence within the context of public violence decline. It studies domestic homicide as a legal, cultural, and historical phenomenon to bring new understanding of origins and attitudes to domestic violence in Modern European society. The project builds on comparative data from main European regions including Eastern and Southern Europe introducing new documents and focusing on such questions as whether decline in public violence by the end of the 18th century can be explained by the domestication of homicide; if and how killing family members facilitated a safer public environment; whether the nature of private violence changed over time and whether private violence is intrinsic to modern society. It is a new and pioneering study looking at early modern European society, using domestic homicide as a filter to identify the level of violence based on the comparison between major European regions. The project systematises previous research, links different disciplines and introduces new empirical data using unconventional geographic understanding of Europe that should push the scholarship to explore EU heritage on the grounds of equal value systems, erasing the heavy built Cold war borderline between the West and the East. The project will result in a monograph, two articles in peer-reviewed journals, and four conference presentations. In addition it will provide connections to and impact on the wider community through networking and Marie Curie Ambassador’s functions to raise awareness about high levels of domestic violence and usage of violence in modern society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'VARIABLE SPEED ULTRA LOW HEAD HYDROPOWER INSTALLATION FOR WINDSOR CASTLE' in the context of a Fourth Framework call.

assistant: **Objectives**

The project aims to install a 260 kW ultra-low head hydropower scheme on the River Thames at Windsor. The power will be consumed entirely by Windsor Castle, displacing electricity from the national grid. The scheme will utilise the power canal and civil works from a disused hydropowered pumping station at Romney Lock, which previously pumped water for the Castle and surrounding area. The installation will consist of 2 propeller turbines operating on a design head of 2.0 m and design flow of 21 cumecs. Two key aims are to prove the technical viability of ultra-low head hydropower schemes operating under varying hydraulic conditions, and to demonstrate variable-speed technology as a means for simplifying the mechanical engineering component and improving reliability without compromising system efficiency. Because of its location, considerable publicity is expected in promoting the benefits of utlising the major renewable resource available at abandoned low head sites.1. Innovative TechnologyThe project will exploit a site with 2 m head on a major UK river, believed to be the first such refurbishment in the UK at such a low head. Two fixed-pitch propeller turbines will be used in a tubular siphon arrangement, the first deployment of this configuration in the UK, instead of a single Kaplan machine. The main technical innovation will be the operation of one of the fixed-pitch turbines at a variable speed to provide the same partflow performance as a double-regulated Kaplan, but at significantly lower cost. An inverter and control system will be modified and transferred from the wind industry to convert variable frequency and voltage electronically to mains-quality AC. Control software will be developed to control the speed of the turbine to maximise total energy capture: the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Centre of Excellence on Inclusive Gender Equality in Research & Innovation: Creating Knowledge & Engaging in Collaborative Action' (INSPIRE), addressing dissemination and exploitation.

assistant: **Impact**

INSPIRE aims to be Europe's sustainable centre of excellence, globally renowned for the quality of its research and analysis produced on inclusive gender equality in research and innovation. It brings together cutting-edge knowledge, ambitious policy approaches, and innovative practices to provide a gateway for scholars, equality experts, practitioners and trainers to connect and share resources, co-create new ones, and link strategically with public and private institutions to benefit the European Research Area. INSPIRE's ambitious research programme develops new, relevant indicators for inclusive GEP development, conducts a GEP monitoring survey throughout Europe whilst identifies key configurations of GEP success and failure. It will fill key knowledge gaps as a result of case studies on intersectional policies, whilst identifying promising practices in gendered regional innovation policy. INSPIRE strengthens the evidence base for informed policymaking and meaningfully engages decision-makers in policy and R&I funding for shaping the future. INSPIRE counts on 4 Knowledge & Support Hubs (KSHs) led by leading academics and renowned practitioners throughout Europe to develop cutting edge knowledge on sustaining change, widening participation, intersectionality and fostering innovation and change in the private sector. These KSHs will provide support to 12 communities of practice (involving more than 95 institutions) to facilitate GEP implementation and foster mutual support for the co-development of innovative practices, customised training, and pan-European data collection. INSPIRE will reduce disparities across Member States and strengthen the ERA through its distributed approach, spreading knowledge, know-how and new opportunities for more open and inclusive research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimal Taxation of Wealth' (Wealth-Taxation).

assistant: **Concept**

There has been a growing concern in public and academia about rising wealth inequality. In his book Capital in the 21st Century, Thomas Piketty has proposed implementing a global progressive “wealth tax” in order to reduce wealth inequality. The book has spurred discussions on wealth inequality and made taxation of wealth a subject of current debate.Wealth can be taxed by different means. While most countries tax income from wealth (capital income tax), some countries have also taxed wealth stock (wealth tax). Given that capital income tax is already used as a means to tax wealth in many countries, what would be the gain in using wealth tax instead or on top of capital income tax? This is one of the main questions that this proposal addresses. Despite the fact that many papers have studied whether it is desirable to tax wealth, the previous literature has been silent about whether capital income or wealth stock should be taxed. This was because most of the previous papers have made the strong assumption that everyone in the economy earns the same rate of return on wealth. Under this assumption, it turns out that capital income and wealth taxes are equivalent. Thus, the previous literature could not provide any rationale for or against using wealth tax instead or on top of capital income tax.The broad objective of this project is to study quantitatively the optimal structure of taxes on wealth and its implications for wealth inequality, economic efficiency, and overall economic welfare by constructing a framework that includes rate of return heterogeneity and other features emphasized to be important in determination of wealth inequality.Wealth taxation is a subject of current debate not only in academia but also in policy circles. This project contributes to this debate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bilateral Coordination for the Enhancement and Development of STI Partnerships between the EU and the USA' to be submitted under Horizon 2020.

assistant: **Abstract**

The EU and the USA have highly-productive, immensely-innovative and excellence-driven research and innovation systems. Acknowledging the particular strengths of each landscape, a balanced transatlantic STI partnership of equals bears great potential and contributes to the ultimate goal of tackling societal challenges and boost economic competitiveness. International cooperation between power nodes results in a constant knowledge exchange and more efficient use of STI investment. BILAT USA 4.0’s targeted transatlantic activities work towards:i) Strategic priority setting for EU-US cooperation through identifying emerging STI fields with a high benefit and added value from cooperation, thus providing evidence-based input for policy decision-making ii) Stronger interaction between EU and US researchers through thematic events promoting funding opportunities on both sides and thus strengthening the quality and quantity of partnerships between STI actors in EU MS/AC and the USAiii) Establishing optimal framework conditions through proposing concrete solutions for eliminating cooperation obstacles deriving from researchers’ and innovators’ feedback, thus, creating an environment that favors joint solutions for global challenges iv) Enhanced coordination and synergies between different policies through analyzing EU, MS/AC and US programmes and detection of duplications, thus, contributing to a greater coherence, joint ownership and resource efficiencyv) Ensuring close synergies with calls launched in H2020 and their int. dimension through screening of US-targeted actions in H2020 and liaising with relevant (ERA) projects to guarantee a consistent information exchange Ensuring sustainability, project activities build on former and liaise with existing initiatives. Relevance and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Divide and conquer ab initio semiclassical molecular dynamics for spectroscopic calculations of complex systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Given the continuing revolution in “nano” and “bio” technologies, it is urgent for chemists to be able to carry out reliable quantum dynamics simulations of complex molecular systems. The goal of this project is to fill the gap between theory and experiment and provide the community with a user-friendly computational tool for nuclear spectra (IR, vibro-electronic, etc.) calculations of very complex systems.Present theoretical methodologies are hampered either by artificial nuclear potential interactions or by local potential perturbation assumptions. The semiclassical molecular dynamics method that I have been pioneering is not affected by these limitations because it is based on ab initio classical trajectories. The nuclear forces can be calculated by any electronic structure software and trajectories can explore the entire potential surface. The remaining challenge is to overcome the exponential scaling of computational power.I will adopt a divide-and-conquer strategy to beat the curse of dimensionality. Firstly, the ab initio classical molecular dynamics is performed for the entire complex system. Then, partial spectra are calculated by using the semiclassical information derived by the projection of the trajectories onto lower dimensional spaces. Vibrational modes are not artificially decoupled. Finally, the entire spectrum is reconstructed piece by piece. This method allows chemists to have a more reliable spectral interpretation in a wider context up to the nanoscale. With the help of my own previous experience and my collaborations, I will simulate pollutant photodegradation for environmental remediation and the vibro-electronic spectra of carcinogenic molecules adsorbed on TiO2. I will also reproduce the spectroscopic properties of molecular nano-texturing of ti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'INLAND WIND FARM OF THREE 755 KW WIND TURBINES AT FORUM - A MONITORING, MEASURING AND DEMONSTRATION PROJECT'.

assistant: **Concept**

- To improve the economic viability of wind turbines in the 750-800 kW range especially aimed at installation at inland sites.- To improve the economic viability of wind power plants by introducing a new control system enabling the adjustment of the blade pitch to accomodate requirements as to noise reduction at specific times.- To demonstrate the viability of a wind turbine equipped with a relatively large light-weight rotor designed for inland sites.- To test the functionality of a new control system enabling the adjustment of the blade pitch in accordance with air density, i.e. temperature and pressure, so as to comply with the requirements concerning grid compatibility of wind turbines to improve the possibility of load management.- To improve wind farm production by using the Wincon Powerstall system and the wind farm control system.1. Innovative technology :- The ability to react to sudden increases in wind speed (i.e. gusts) and limit the excess power output from the wind turbine quickly (grid compatibility) without grat stress to the structure.- The avoidance of large seasonal variations in power output due to changes in the air density as a result of diurnal and seasonal changes in temperature and pressure.- The introduction of a predetermined 'low-moise' pitch angle for use at specific hours and times (night hours, weekends, etc.) achieved by adjusting the blades' pitch angle.- The fulfilment of requirements as to load management at times when the grid cannot absorb the full output by way of the Central Monitoring and Control System's ability to monitor the collective data for all three wind turbines and make adjustements to each wind trubine to meet the total plant power output objective.2.Context of the technology :If the EU's objectives for wind energy are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Use of nmr spectroscopy in combination with computational methods on systems of biological interest' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Expected results:* publications and patent applications, presentation of the results at international conferences, annual reports to EU,* graduate and post-doc education,* development of new methods to study metabolism of carbohydrates, complex enzymatic reactions, characterization of protein folding, peptidomimetic drugs and glycopeptides antibiotics,* summer school on NMR and molecular modelling, and NMR conference.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanoelectronic COupled Problems Solutions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Designs in nanoelectronics often lead to problems that are large to simulate and that include strong feedback couplings. Industry demands to include variability to guarantee quality and yield. It also requests to incorporate higher abstraction levels to allow for system simulation in order to shorten design cycles, while preserving accuracy. The nanoCOPS project considers the simulation of two problem classes identified by industry:- Power-MOS devices, with applications in energy harvesting, and which involve couplings between electromagnetics (EM), heat, and stress, and- RF-circuitry in wireless communication, which involves EM-circuits-heat coupling and multirate behaviour, together with analogue-digital signals.Due to the market demands, the scientific challenges are to- create efficient and robust simulation techniques for strongly coupled systems, that exploit the different dynamics of sub-systems and that can deal with signals that differ strongly in the frequency range;- include variability such that robust design, worst case analysis, and yield estimation with tiny failures are possible (including large deviations like 6-sigma);- reduce complexity such that one can still vary parameters and such that the reduced models offer higher abstraction models that are efficient to simulate.Our solutions are- advanced co-simulation/multirate/monolithic techniques, combined with envelope/wavelet approaches;- new generalized techniques from Uncertainty Quantification (UQ) for coupled problems, tuned to the statistical demands from manufacturability;- enhanced, parameterized Model Order Reduction techniques for coupled problems and for UQ.All algorithms will be validated in the industrial design tools provided by our industrial partners.Our consortium covers extensive R&D ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OPerating RAck For Full-Electric Vehicle' to be submitted under Seventh Framework.

assistant: **Abstract**

To improve deployment of electrical vehicles in Europe, large scale production processes for Rack, cells and electrical components need to be developed. The OPERA4FEV project aims to develop a cost effective innovative thermoplastic battery rack, able to integrate any type of cylindrical cells. The solution proposed by OPERA4FEV project, adaptable to any Full Electric Vehicle model, will indeed integrate electrical, hydraulic connections and component housing  to reduce cost assembly. In order to show the relevance of the solution and meet strong industrial benefits, the rack will be integrated on two functional demonstrators.The whole value chain will be addressed, including the eco-design (dismantling and recycling of critical materials), assembly/integration and production of cells  and electrical components. As safety of the on-board battery in electric, hybrid, and plug-in vehicles is of paramount importance to the international automakers, OPERA4FEV will pay particular attention to the evaluate the effects of the rack characteristics regarding vehicle crash safety, and will focus on the potential risks for the vehicle and its occupants in case of failure of one or more batteries. To sum up, the main innovations of the OPERA4FEV project are : Thermoplastic rack integrating the electrical and hydraulic connections ; use of thermoplastic pultruded reinforcements, infrared welding for plastic part assembly ; improved regulation and heat transfer ; use of recycled material ; recycling and End of Life ; weight reduction ; Life Cycle Assesment ; reduction of number of components ; maintain the cells in the rack reversibly and lighter with robust tightness ; establish fast connections.