RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Predicting of Prokaryotic Defence Distributions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Bacteria are crucial for health, nutrient cycling and biotechnology but face a constant pressure from the viruses that infect them (phages). As such, bacteria have evolved a sophisticated suite of defence mechanisms that allow them to evade phages. These defence mechanisms can be classified into two basic classes: selfish or altruistic. A selfish system protects individuals, whereas an altruistic system protects the population. Interestingly, the distribution of this defensive arsenal is uneven, with large variations in the types carried, even among closely related species. This proposal aims to understand the basis of this distribution by using a multi-disciplinary approach that combines the precision of a model laboratory system with cutting-edge metagenomics techniques. Specifically, I will use abortive infection as a model for altruistic defence and CRISPR as a model for selfish defence and test the role of spatial structure in determining the abundance of each type. High spatial structure is predicted to be a key determinant of altruistic defences as it results in proximate bacteria being closely related. I will then apply the findings from the first objectives to classify a novel, recently discovered, defence system. Together, these results will enable researchers to better understand microbial immunity, with key consequences for industry and healthcare.  The outgoing phase will take place at the University of Otago, New Zealand, using molecular biology expertise in abortive infection and CRISPR systems. The return phase will take place at the University of Exeter, UK, benefitting from expertise in ecology and evolution. The proposed project will allow me to complement my strong background in genomics and ecology with molecular biology and novel bioinformatic appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimental and Numerical Analyses of the Dynamic Behavior of Rolling Tires in order to Improve the Tire Modeling Accuracy' (TIRE-DYN).

assistant: **Concept**

The increasing complexity and shorter development times of vehicles require more accurate and efficient simulation tools. Already in the early phases of the vehicle development, a reliable prediction of the tire dynamic behavior is required to assess and optimize vehicle performances, such as, tire/road noise, handling, ride comfort, vehicle NVH (Noise, Vibration and Harshness) and durability. In addition, the tire dynamic behavior plays a key role in several new automotive technologies, such as, intelligent driver assistance systems, active suspension, in-wheel electric drive, intelligent tires,… The objective of this project is to obtain more accurate structural tire models through a better understanding of the influence of rolling on the tire dynamic behavior. Up till now, the physical phenomena that determine the complex dynamic properties of a rolling tire are not fully understood due to the strong multi-disciplinary nature of the subject. Consequently, the current tire models are not able to provide an efficient and accurate prediction of the rolling tire dynamic behavior. This project studies the physical phenomena through an integrated approach in which the state-of-the-art in the field of experimental and numerical tire dynamic analyses are linked and consolidated. Based on the obtained insights, the effects of rolling will be implemented in existing tire models in order to improve their accuracy and applicability. The developed implementations will be experimentally validated afterwards. The integrated research approach of this project is based on a continuous transfer of scientific and engineering knowledge between industry and academia. Through secondments, recruitments, training and networking activities, this knowledge will be efficiently transferred. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Physical and molecular underpinnings of the multifunctionality of bacterial peptide assemblies' (PUMBA) under Horizon Europe.

assistant: **Objectives**

An important challenge in biophysics is to understand the complex biological functions emerging from the physico-chemical properties of simple building blocks. Showcasing this challenging question is the multiple functions achieved by the phenol soluble modulins (PSMs) peptides from Staphylococcus aureus, able to self-assemble into amyloid structures, and underlying S. aureus pathogenicity. Over the past decade, the intrinsic capacity to form fibrils in vitro has been directly correlated with the peptide biological activities in vivo. This traditional focus severely limits our understanding of the role of more complex intermediate structures and dynamic interactions with the encountered biological membranes. Here, I propose to uncover the molecular determinants and mechanisms of self-assembly and its implication in dictating PSMs multifunctionality, from biofilm formation to inflammation and toxicity. I hypothesize that, beyond the current one structure  one function paradigm, intermediate assemblies are the membrane active entities and their co-aggregation with membrane components, such as lipids and proteins, contribute to their distinct functions. Building on my prior work on PSM3 and my leading force in single-cell and single-molecule characterizations, I will: 1. Reveal the mechanism of self-assembly and the role of lipid co-factors2. Uncover the molecular modes of action of diverse assemblies at the membrane interface3. Establish in vivo how these assemblies drive host cell inflammation and death4. Explore the role of self-assembly in bacterial adhesion, in turn biofilm formationBy pinpointing the key characteristics of PSMs assemblies, from their physico-chemical to structural properties, responsible for their different functions, this project could set the basis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unifying ecophysiological predictions of ectotherms to global warming' in the context of a Horizon Europe call.

assistant: **Objectives**

Ongoing climate change represents a major threat to biodiversity, and scientists now face pressing concerns to forecast how ecological communities will respond to global warming in the medium- to long-term. However, the current framework to study heat tolerance rely on critical thermal limits (CTmax), which comprises a coarse metric that has been shown to be unrealistic. Not only results from CTmax are ludicrous, they do not allow for temporal forecast. Unfortunately, this is what overwhelming majority of research groups are now measuring, at an enormous waste of time and human effort. The e_WARM project proposes the ambitious umbrella objective of stablishing a unified predictive framework for the study of heat tolerance in terrestrial and aquatic ectothermic animals. For this purpose, the candidate will develop a novel comprehensive analytical toolbox to anticipate heat mortality with a unprecedented accuracy and reliability. This approach translates high-resolution temperature records from the field into realistic mortality rates of species. Importantly, the analytical routines proposed can be expanded to include the interplay of warming with other factors, such as heat waves, phenotypic plasticity or hypoxic stress. As a proof of concept, the candidate will study Drosophila species as model organisms from terrestrial, and Daphnia species (invertebrate) and Galaxias maculatus (fish) as model organisms from aquatic ecosystems, The subject of the e_WARM project is both timely and important, as more reliable predictions of the impact of global warming on populations’ resilience are urgently needed. Repercussions of this research will be immediately transmitted to the society, and they will have a big scientific, political, economic and health impact.


**Keywords:** Cli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'PHYSICS BEYOND the STANDARD MODEL'.

assistant: **Concept**

The wide scope of the proposed work demands an efficient cooperation among further strengthen the current collaboration amongst a group of european the various groups involved. We plan to devote particular emphasis on the centers working in many aspects of Physics Beyond the Standard Model". training and active participation of young scientists in the proposed exchanges, which has already been the tradition in a number of the nodes The participating teams current activities clearly demonstrate their common involved. In particular, we propose the opening of 13 two-years scientific interests, solid expertise, and complementary methods of post-doctoral positions distributed among the participating institutes treating the same problems. Of these topics to highlight we include: the through the duration of the contract. unification of fundamental forces including gravity, strings and superstrings, electroweak symmetry breaking, higgs physics and supersymmetry, as well as neutrino physics. We plan to cover both the theoretical as well as the phenomenological implications of the most promising class of extensions of the standard model of particle physics, in an attempt to provide support and stimulus to the main european experimental programs in high energy physics at the LEP and LHC colliders."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards spatially-controlled, bioorthogonal, CuAAC-mediated assembly of targeted oncoprotein degraders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

I propose an ambitious multidisciplinary strategy to address the challenge of targeting KRAS-mutated cancers through the combination of a novel bioorthogonal strategy to assemble bioactive agents and ‘targeted protein degradation’ (TPD). TPD is an innovative strategy to degrade targeted proteins by hijacking the natural Ubiquitin Proteasome System (UPS) employing heterobifunctional molecules called Proteolysis Targeting Chimeras or PROTACs. These compounds have demonstrated the ability to drive the destruction of well-known harmful proteins. However, their therapeutic implementation has been severely limited by the large size and lipophilicity of these molecules, and by concerns of systemic toxicities. Here, we propose these issues could be circumvented by that the use of PROTACs against KRAS that are assembled from two drug-like fragments via bioorthogonal copper-catalyzed azide alkyne cycloaddition (CuAAC) mediated by Cu nanoparticles (Cu NPs) located in the tumour anatomical area. Furthermore, to avoid the Cu NPs loss of catalytic performance caused by their interaction with the biological milieu, we propose to protect them in sachets made out of a dialysis membrane to avoid biofouling and at the same time, facilitate the entry of precursors of bioactive PROTACs. This highly innovative project has the potential to create far-reaching tools for cancer therapy, and in doing so, promoting European Scientific Excellence. By completing this multidisciplinary work, the applicant will be in an excellence position for create cross-disciplinary collaborations with research groups and industry across Europe and to becoming himself as an independent researcher


**Keywords:** Copper-nanoparticles, proteolysis targeting chimeras, KRAS protein degradation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated absolute dating approach for terrestrial records of past climate using trapped charge methods' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The practice of tuning different climate proxies prevents the observation of regional response times of terrestrial archives to global changes. Thus, it is imperative to develop correlation protocols based on absolute chronologies. Loess-palaeosol deposits are continental archives of Quaternary paleoclimates and loess is generally considered an ideal material for the application of luminescence dating. The agreement obtained for 10-20 ka ages using different techniques has given us confidence in using the state of the art measurement protocols for young deposits, as confirmed by comparison with independent age control. INTERTRAP proposes detailed investigations of loess samples from three continents collected in close proximity to the transition to the recent soil, with the purpose of obtaining a temporal quantification of the ending of the Late Tardiglacial and the beginning of the Holocene. However, a series of recent luminescence investigations carried out on quartz of different grain sizes extracted from Romanian and Serbian loess yielded severe age discrepancies for ages >~40 ka. While the cause of this observation is hitherto not fully explained, our ongoing studies on Chinese loess prove that it is a general effect, potentially affecting deposits worldwide, and raising doubts on previous chronologies. Methodological studies within INTERTRAP will develop an integrated approach using optically stimulated luminescence, thermoluminescence and electron spin resonance investigations. This part of the study aims at unravelling the mechanism responsible for the observed discrepancies and developing innovative trapped charge dating measurement protocols based on quartz that will yield reliable ages for and beyond the last interglacial glacial cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cooper pairs as a source of entanglement' in the context of a Seventh Framework call.

assistant: **Objectives**

Entanglement and non-locality are spectacular fundamentals of quantum mechanics and basic resources of future quantum computation algorithms. Electronic entanglement has attracted increasing attention during the last years. The electron spin as a purely quantum mechanical two level system has been put forward as a promising candidate for storing quantum information in solid state. Recently, great progress has been achieved in manipulation and read-out of quantum dot based spin Qubits.  However, electron spin is also suitable to transfer quantum information, since mobile electrons can be coherently transmitted in a solid state device preserving the spin information. Thus, electron spin could provide a general platform for on-chip quantum computation and information processing.Although several theoretical concepts have been worked out to address spin entangled mobile electrons, the absence of an entangler device has not allowed their realization so far. The aim of the present proposal is to overcome this experimental challenge and explore the entanglement of spatially separated electron pairs. Superconductors provide a natural source of entanglement, because their ground-state is composed of Cooper pairs in a spin-singlet state. However, the splitting of the Cooper pairs into separate electrons has to be enforced, which has been very recently realized by the applicant in two quantum dot Y-junction. This Y-junction will be used as a central building block to split Cooper pairs in a controlled fashion and the non-local nature of spin and charge correlations will be addressed in various device configurations.Our research project will lead to a fundamental understanding of the production, manipulation and detection of spin entangled mobile electron pairs, thus it will signifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Point-of-care microfluidic device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The decision-making in chemotherapy nowadays depends on standard methods that are liquid chromatography (LC-MS/MS) followed by mass spectrometry or capillary electrophoresis; both are labour- and cost-intensive and can be performed only in dedicated hospitals and laboratories. This lead to a minimal therapeutic drug monitoring in patients and hence that 30-60% of drugs are administered without clinical benefits.  We propose to develop a point-of-care device for quantification of chemotherapeutic drugs in small body fluid samples by highly selective nanoparticle extraction and liquid crystal detection incorporated in microfluidic lab-on-chip device (optofluidics based) allowing the real-time drug monitoring. This will improve the therapeutic outcome and reduced health care costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HitSeed application for the Horizon 2020 dedicated SME Instrument - Phase 1 2014. September 2014.' (HitSeedSME-1-09-14).

assistant: **Innovation**

HitSeed is conducting a feasibility study on their revolutionary Internet of Things (IoT) platform, which includes hardware, software, industrial design and software development tools. The platform is technologically novel, as it combines modern microcontroller-based hardware with touch display and graphical user interface providing unprecedented customer benefits,like low power consumption and significantly reduced unit cost. Most  importantly, the IoT platform is disruptive, as it brings development costs down to completely new levels and shortens the IoT deployment time-to-market from 1-2 years to months or weeks while simultaneously reducing the risk level. It also allows the expansion of IoT solutions to domains that have not been feasible before, including e.g. mobile, ""fire-and-forget"" type of IoT sensor and monitoring devices.There is a clear customer need for our platform as many companies in Europe and globally struggle with finding a proper solution for their IoT needs or need to accelerate their product development to stay competitive. Potential customers vary from small startups developing consumer IoT products in various domains like household appliances or wellbeing to large enterprises needing a tested HW platform to boost their own product development e.g. for industrial clients. We estimate that the commercial potential for IoT devices based on our platform is 38 MEUR in 2017 with indirect impact being in the range of 600 new jobs in Europe, increased competitiveness of European industry, and an estimated customer value add of over 300 MEUR.During the feasibility study we are planning to do an IoT opportunity identification, build a business plan, develop a minimum viable product for IoT including an industrial design, as well prepare to pilot the so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Environmental friendly roof-covering with long life potential'.

assistant: **Innovation**

Nowadays, many houses are covered with roof slabs, consisting of several panel elements. These roof panels are made of high quality galvanized steel, which, after compression, is coated with a base coating and natural grit. Partly due to the increase in steel price (the costs of production have risen with 50% in one year) other base material had to be found to create a cheaper product. After extensive research and testing it was concluded that it is possible to create a new kind of base material, consisting of a mixture of waste materials, such as plastics. This is waste production material coming from the furniture industry and consists of natural compounds and plastics. In an innovative production process the new base material is created and shaped in various forms through heating and the application of a coating of granulate. The granulation process allows for the application of many colors to the product in a relative simple and cheap way. The end result is a product that is 70% cheaper than old one, 50% lighter in weight and has a long life span.