RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting the role of BRCA2 in the DNA damage response and exploiting its parts for anticancer therapy' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Mutations in the tumor suppressor gene, BRCA2, cause susceptibility to breast and ovarian cancer. BRCA2 protein is required for homologous recombinational DNA repair (HRR), the predominant mechanism employed by cells to accurately repair DNA double-stranded breaks (DSBs). In humans, the central player of the HRR process is RAD51; it catalyzes the DNA strand exchange that results in the repaired DNA. Through its interaction with RAD51, BRCA2 controls RAD51 function by locating it to the DSBs. Thus, defects in BRCA2 lead to genomic instability, a hallmark of tumorigenesis.During my postdoc, I have revealed important aspects of BRCA2 protein, the regulatory function of the BRC repeats of BRCA2 on RAD51 DNA binding selectivity as well as contribute to the first biochemical characterization of the full-length BRCA2 protein.In an interdisciplinary approach and, as an independent researcher, my main goals are to:1) Reveal new roles of BRCA2 by mapping the interactions with other proteins: For example, recently a DMC1 interacting site on BRCA2 has been reported involving BRCA2 in meiotic recombination.2) Better understand the HRR process: Evidences from the BRCA2 homologue in fungus point to another DNA binding site in BRCA2; finding this region in the human protein may decipher important aspects of the regulation of HRR that remain elusive.3) Exploit regions of the protein as a therapeutic tool for tumor treatment. We will use peptides derived from BRCA2 protein that are involved in interactions with key proteins in the HRR pathway to block this pathway in tumors cells.4) Develop new strategies to carry these peptides to the targeted tumor cells.The combination of basic science (aims 1, 2) and applied science (aims 3, 4) approaches proposed here provides a framework to underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sloshing Wing Dynamics' (SLOWD) targeting Horizon 2020.

assistant: **Abstract**

SLOshing Wing Dynamics (SLOWD) aims to investigate the effect of sloshing on the dynamics of flexible, wing-like structures carrying a liquid (fuel), through the development of experimental, numerical and analytical methods, and to use sloshing to reduce the loads occurring from gusts and turbulence.Its main goal is to provide a holistic approach (both experimental and numerical) in order to quantify the energy-dissipation effects associated with the liquid movement inside the fuel tanks, as the wing undergoes dynamic excitations. An increase of the order of 50% in the damping characteristics of the structure is expected.


**Keywords:** Sloshing, Wing, Dynamics, Experimental, Numerical, CFD, FEM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative Business Models for Market Uptake of Renewable Electricity unlocking the potential for flexibility in the Industrial Electricity Use'.

assistant: **Innovation**

The flexibility of the industrial electricity demand has been identified as a potential that through innovative business models can facilitate further growth of variable renewable energy, while reducing the industrial electricity costs and contributing to the European energy policy goals. In this project the large industry is working with the renewable energy community to identify and implement business models for supplying variable renewable electricity to industrial users with flexibility in their demand, creating win-win situations. Several variations of the business models will be described covering different options like on and off-site renewable energy production. The business models will be adapted to 5 industrial sectors (Chemicals, non-ferrous metals, cold storage, steel, and water treatment) and 6 target countries (Belgium, France, Germany, Italy, Spain and UK). Tools will be developed to facilitate adoption of the business models: Model contracts adapted to the target countries and the different business models and a methodology that assesses the flexibility in industrial units and its value within the business models. The methodology will be transferred to third parties and will be applied in 6 case studies covering all target sectors and countries. Recommendations for improvements in the regulatory and market framework will be formulated and promoted. A top-down and a bottom-up methodology will be used to quantify the potential for further cost-effective grid integration of variable renewable electricity by the exploitation of the industrial electricity demand flexibility. The use of a sophisticated power system model and detailed analysis will provide reliable data on the impact the policy recommendations could have. An ambitious campaign will be carried o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamic Libraries for the Synthesis of New Multifunctional Silica Striped Nanoparticles' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The last decades have been characterized by a great interest on nanotechnology applied to biology and medicine. Nanoparticles play a leading role thanks to their novel properties relative to their bulk material counterparts. Within TransformerSurfaces the training-through-research is targeted at synthesizing silica nanoparticles, coated with a molecular monolayer that can in turn be reversibly functionalized with different ligands following the principles of the Dynamic Combinatorial Chemistry (DCC). The goal is to obtain a new surface suitable for a larger range of possible functionalization. In particular, taking inspiration from the striped gold nanoparticles that have been recently discovered in the group, this project is targeted to functionalize the outermost coating of the silica nanoparticles with higher order patterns, especially stripes. In fact, these ‘striped’ nanoparticles are capable of penetrating cell membranes without porating (creating transient holes associated with leakage and cytotoxicity) as viruses do. Additionally by combining the biocompatibility of silica with the low toxic effect given by the optimization of the ligands arrangement on the surface, we aim to erase the toxicity of nanoparticles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EMBL Interdisciplinary Postdocs 2' (EIPOD2).

assistant: **Concept**

The European Molecular Biology Laboratory (EMBL) has a strong tradition in promoting interdisciplinary basic research in molecular biology. With 83 laboratories in eight Research Units at five facilities in four European countries, working on topics ranging from structural to organismal biology and from computational and biophysics to chemical biology, the EMBL is one of the top research institutions in the world. The EMBL Interdisciplinary PostDoc (EIPOD) fellowship programme makes use of this unique international, multidisciplinary research environment to broaden the interdisciplinary education and expertise of Experienced Researchers (ERs). Once a year, EMBL invites young researchers to propose interdisciplinary projects of their choice to EMBL faculty of their preference. Candidates are asked to contact at least two group leaders, preferably from different research units, to discuss and shape projects that bring together separate scientific disciplines or transfer techniques to new usage. Scientific excellence of applicants and interdisciplinarity of the proposed work are evaluated by an independent selection committee composed of EMBL Heads of Unit and other external internationally renowned scientists in a two-step procedure, involving a pre-selection followed by an interview meeting. Besides high-level interdisciplinary research training, EIPODs receive additional vocational training, special career development support and can join the EMBL double mentorship scheme. An active alumni network facilitates reintegration into national research environments. Fellowships last three years. The COFUND contribution will be used to maintain our current number of fellowships of 20 per year and to introduce additional social benefits for the EIPODs in accordance with the Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure and Thermodynamics of Adhesin-Mediated Virulence in Enterococci: Overcoming Fortified Biofilms' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Gram-positive Enterococci account for a significant fraction of hospital-acquired infections but are often difficult to treat due to their proficiency in colonizing damaged host tissues, forming biofilms, and acquiring and spreading antimicrobial resistance (AMR). These AMR genes and additional virulence factors are often disseminated among the bacterial population via conjugation, the horizontal transfer of mobile genetic elements between cells in physical contact. Type 4 Secretion Systems (T4SSs) facilitate conjugation, and a key feature of many Gram-positive T4SSs are cell surface-anchored adhesion proteins. Adhesins not only stabilize mating pair junctions during conjugation but also promote biofilm formation and adherence to host cells during infection, making them a major factor in why hospital-acquired Gram-positive infections are so difficult to treat. One such adhesin is PrgB, which is encoded on the conjugative pCF10 plasmid from Enterococci faecalis. The Berntsson lab has previously characterized a subset of PrgB binding partners involved in biofilm formation, but the features of PrgB-host interactions required for infiltration and colonization remain unknown. In this proposed research, I aim to identify host-derived receptors that interact with PrgB, quantify the thermodynamic parameters of binding, and structurally resolve important binding interfaces. The resulting molecular details will explain how these adhesins confer virulence by promoting pathogenic colonization of host tissues, stabilizing mating pairs during conjugation, and initiating biofilm formation. This information will be important to the development of new strategies to mitigate the virulence of pathogenic Enterococci and Gram-positive bacteria more broadly.


**Keywords:** Adhesion Protein,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The skeletal effects of historical transitions in lifestyle'.

assistant: **Innovation**

In the last 10 millennia humans have changed the way we live, moving from mobile hunter-gathering to farming and the urban living we are most familiar with today. Since 2008 more than 50% of the global population live in cities. But what effect has this had on our bodies? Understanding how we have adapted to past transitions is vital to interpreting archaeological remains and to anticipate the physical effects of this ongoing modern transition to a highly technologically dependent urban species. The goal of TRANSITIONS is to develop the research capacities of the European Fellow, in his broad area of interest in human variation and evolution. It will provide advanced training in the context and study of the skeletal consequences of changes in lifestyle and activity through a series of defined objectives for resaerch and training that  compare skeletal form and function within and between past populations with different subsistence and lifestyle strategies; hunter gatherers, agriculturalists and urban dwellers. The results will provide new insights into how different lifestyles and their functional consequences affect skeletal form.  Multiple factors impact on the skeleton, yet there is a discernible, consistent trend with increasing modernity towards ‘gracilization’. Thus, despite the multifactorial causes, to what extent are skeletal effects similar or different between transitions to agriculture and to urban or other ways of life? The answer will reflect how flexible our responses are to similar and different pressures and the extent to which we can use knowledge of historical transitions to interpret archaeological material and anticipate current and future ones.  As well as providing advanced training by applying cutting-edge techniques, The ER will be supervised an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chromatin architecture and Design' (ChromDesign) under Horizon 2020.

assistant: **Objectives**

ChromDesign is an innovative and interdisciplinary network of 10 European academic and private institutions that will characterize how 3D chromatin organization affects gene regulation during cellular differentiation and in several human disorders. We will train 13 Early Stage Researchers (ESR), equipping them with the skills, knowledge, expertise, and enthusiasm necessary to develop successful future careers in the biomedical field (in academia or the private sector). Together with European experts in chromatin biology, 3D genomics, and research design, these ESRs will work towards the goal of identifying novel alterations in chromatin topology responsible for cellular malfunctions to: i) develop new diagnostic tools, ii) effectively communicate research results through specific toolkits; and iii) identify novel therapeutic targets with the potential to be exploited as treatments.Alteration of gene regulation occurs naturally during aging and underlies several human diseases. Its better characterization requires a deeper understanding of the spatial organization of the genome. We will investigate how the genome organizes in 3D over time, and how the 3D organization is related to gene regulation in health and disease. We will use and develop technologies in imaging, cell biology, genomics, and computational modelling and will focus on translating our results into clinical applications. ESRs will thereby receive training with state-of-the-art technologies in distinct research areas and in modules with theoretical and hands-on sessions on transferable skills: entrepreneurship, management, communication, and outreach. ChromDesign comprises 6 work packages: WP1–4 address the 4 main areas of chromatin biology and 3D genomics; WP5 applies the knowledge obtained from WPs1–4 in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Open Controller Enabled by an Advanced real-time Network' (OCEAN).

assistant: **Concept**

The main problem in the control area is still that no big control vendor has an interest in open specifications. The OCEAN project will break this situation. It will give the end users a clear perspective that OCEAN open source based architecture (Linux, CORBA) combined with standards like POSIX, IEC61l31, IEC61508, will result in competitive products. If the CNC manufacturing companies accept this idea there will also be a big move towards opening today' s closed sources. In particular the OCEAN proposal will allow to integrate additional functionality and third party software just using the standardised interface description, and the merge components provided by different CNC manufacturers.Objectives:The two main objectives of the proposal are:i) the development of a distributed control system real-time framework (DCRF) for numerical controls based on standardised communication systems and delivered as open source;ii) an extended component-based open control reference architecture, not delivered as open source but with publicly available new standardised interfaces for motion control components of machine tools which will make use of the DCRF.Work description:The workplan is organised in order to achieve the main goals of the project, which are:1 . The development of an open source real -time framework (DCRF) for distributed control systems based on open communication standards and Open Source software;2. The new and extended design of an open control system architecture by subdivision of complex control structures into components with standardised interfaces.WPl and WP2 will realise the first goal, WP3 and WP4 the second goal. The result of WP1/2, which is the DCRF, is needed to host the control applications developed in WP3/4.The new concepts will be demonstrated wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bioinorganic Chemistry for the Design of New Medicines' in the context of a Seventh Framework call.

assistant: **Objectives**

Bioinorganic chemistry is a rapidly expanding area of research, but the potential for the therapeutic application of metal complexes is highly underdeveloped. The basic principles required to guide the development of metal-containing therapeutic agents are lacking, despite the unique therapeutic opportunities which they offer. It is the goal of the proposed research to establish basic principles of medicinal coordination chemistry of metals that will allow the rational screening of future metallopharmaceuticals. We propose to utilize the power of inorganic chemistry to provide new knowledge of and new approaches for intervention in biological systems. This will be based on improved understanding of reactions of metal complexes under physiological conditions, on improving the specificity of their interactions, and gaining control over the potential toxicity of synthetic metal complexes. The research programme is highly interdisciplinary involving chemistry, physics, biology and pharmacology, with potential for the discovery of truly novel medicines, especially for the treatment of diseases and conditions which are currently intractable, such as cancer. The challenging and ambitious goals of the present work involve transition metal complexes with novel chemical and biochemical mechanisms of action. They will contain novel features which allow them (i) to be selectively activated by light in cells, or (ii) to be activated by a structural transition, or (ii) exhibit catalytic activity in cells. This ground-breaking research potentially has a very high impact and is based on recent discoveries in the applicant s laboratory. A feature of the programme is the use of state-of-the-art-and-beyond methodology to advance knowledge of medicinal metal coordination chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low-cost Smart Sensor Systems' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The scientific nd technical objectives of this research proposalconcern the development of low-cost smart sensor systems, which consist of a sensing element, a novel snsor interface (SI) and a microcontroller. The system should be universal, easy-to-use and have features and auto-calibration and self-testing. Research is required to make the sensor interface universal, so that it can support a wide variety of low-cost sensing elements, including capacitive and resistive elements as well as voltage-, current- and charge-generating elements. Further research and development is required to integrate the novel sensor systems in en products: smart thermal, capacitive, magnetic and chemical ssensor systems. More research and development will be needed to integrate the smart sensor systems with control systems or instrumentation & measurement equipment. Problems and opportunities related to the application of these low-cost sensor systems are addressed.