RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional assays for membrane protein on nanostructured supports' (ASMENA), addressing dissemination and exploitation.

assistant: **Impact**

More than 50% of all drug targets are membrane proteins; new research tools to screen function of membrane drug targets are therefore expected to open up new avenues for original drug development. The proposed project addresses the need of the pharmaceutical industry for new technologies for reliable and efficient screening of membrane proteins as drug targets. Most critical current aspects of membrane protein assays are (a) the lack of reliable procedures to immobilize membrane proteins on sensor surfaces in a format suitable for label-free high-throughput screening of drug candidates; (b) the need for downscaling assay formats to accelerate functional screening; and (c) the feasibility of reading out the diverse functions of membrane proteins. The partners – with highly complementary expertise and experience of working together – will develop platforms for functional membrane protein assays by integration of the most recently gained knowledge and techniques. The key concepts of the platforms include (a) exploitation of nanoporous substrates to enhance the stability of supported proteolipid membranes and their integration in a sensor chip format; (b) nanoscale surface modifications for directed self-assembly of proteolipid structures on chip; and (c) self-assembly of proteolipid membranes onto nano-sized sensor structures from proteoliposomes, and demonstration of the functionality in quantitative drug candidate screening assays suitable for commercial applications. The project is expected to make a substantial contribution to (a) improved understanding of lipid membrane and membrane protein interaction with designed nanoenvironments; (b) development of prototype products and intellectual property related to membrane protein sorting and handling; (c) new compounds for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dietary shaping of the early life metabolome and its role in healthy lung and brain development'.

assistant: **Concept**

Asthma and behavioral problems related to neurodevelopmental delay such as ADHD and autism are common childhood disorder with lack of insight in disease mechanisms and no preventive measures, which is an unmet medical and societal need. In the Danish COPSAC mother-child cohort, I showed in two randomized trials that pregnancy supplements with n-3 long-chained polyunsaturated fatty acids (n-3 LCPUFA) and high-dose vitamin D reduced offspring asthma risk, improved cognitive scores and accelerated language and milestone achievement, which was replicated in the American VDAART vitamin D trial. This holds the promise for primary prevention but establishing underlying biochemical mechanisms and effect modification by maternal and early life diet and host genetics remains to achieve a personalized preventive strategy targeting supplements only to those women, whose offspring will benefit from it. This research project aims to understand how dietary supplements and diet in pregnancy and early life shapes the childs metabolism and how this is linked to asthma and neurodevelopment, using longitudinal untargeted and targeted metabolomics profiles from more than 1,500 mother-child pairs in COPSAC and VDAART, detailed data on maternal and infant diet, the early life exposome, and genetics and genomics data. The objective is to identify metabolites and biochemical pathways of importance for asthma and neurodevelopment, focusing on n-3/n-6 LCPUFAs, sphingolipids and tryptophan, with the ultimate goal to achieve healthy lung and brain development through personalized diet interventions during pregnancy. The transdisciplinary study group lead by the applicant consisting of MDs with pediatric, respiratory and psychiatric expertise, wet and dry lab metabolomics experts and bioinformaticia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Extreme Citizen Science: Analysis and Visualisation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The challenge of Extreme Citizen Science is to enable any community, regardless of literacy or education, to initiate, run, and use the result of a local citizen science activity, so they can be empowered to address and solve issues that concern them. Citizen Science is understood here as the participation of members of the public in a scientific project, from shaping the question, to collecting the data, analysing it and using the knowledge that emerges from it. Over the past 3 years, under the leadership of Prof. Muki Haklay, the Extreme Citizen Science programme at UCL has demonstrated that non-literate people and those with limited technical literacy can participate in formulating research questions and collecting the data that is important to them. Extreme Citizen Science: Analysis and Visualisation (ECSAnVis) takes the next ambitious step – developing geographical analysis and visualisation tools that can be used, successfully, by people with limited literacy, in a culturally appropriate way. At the core of the proposal is the imperative to see technology as part of socially embedded practices and culture and avoid ‘technical fixes’.The development of novel, socially and culturally accessible Geographic Information System (GIS) interface and underlying algorithms, will provide communities with tools to support them to combine their local environmental knowledge with scientific analysis to improve environmental management. In an exciting collaboration with local indigenous partners on case studies in critically important, yet fragile and menaced ecosystems in the Amazon and the Congo-basin, our network of anthropologists, ecologists, computer scientists, designers and electronic engineers will develop innovative hardware, software and participatory methodologies th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ambulatory Magneto-Enhancement of Transdermal High Yield Silver Therapy' (AMETHYST), addressing dissemination and exploitation.

assistant: **Impact**

There are approximately 2 million people  who suffer from chronic wounds such as venous leg ulcers in Europe at the present time. These wounds typically take between 12 and 24 weeks to heal, but 30% take over two years. This represents a cost to the European healthcare services of at least €8 billion  a year in treatment. Two thirds of cases are released immediately for treatment in the community, and it is common for 40% of community nurses’ time to be taken up by the management, dressing and care of this type of wound.  In addition to the above, one of the reasons behind the phenomenon of antibiotic resistant bacteria is the widespread use of medication when there is no clinical infection. If low level silver ion dressings could be used in prophylaxis instead of antibiotics there would be an additional saving in terms of the cost of treating patients who contract antibiotic resistant infections. More importantly the incidence of antibiotic resistance will be lower.  Current wound treatments are either expensive, inadequate or dangerous. Our idea provides a way of enhancing the effectiveness of silver-containing dressings used in the treatment of ulcers by creating a pulsed electromagnetic field at the wound site by the incorporation of a pulsed electromagnetic element in a low silver dressing. The pulsed electromagnetic field increases the concentration of silver ions available to the wound bed margin.   The device is designed to be worn by patients in their every-day lives without the need to attend a medical facility for treatment. The system consists of two distinct components – an electronic pulse generator and an electromagnetic component contained in a disposable surgical dressing which is impregnated with silver-containing nanoparticles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Candidate mutation discovery in early-flowering mutants 'Rojo Pasión Precoz' and 'Bulida Precoz'' (PrunMut) targeting Horizon 2020.

assistant: **Abstract**

Whole-genome sequencing using novel Next Generation Sequencing (NGS) technologies allows to mine for induced genomic or transcriptomic differences in non-model plant species, and is providing a universal and generic platform for the isolation of genes including spontaneously mutated loci important for breeding or biotechnological applications. Moreover, two spontaneous early-flowering apricot mutants ‘Rojo Pasión Precoz’ and ‘Búlida Precoz’ have been recently discovered in Southern Spain, derived from commercial cultivars. This unique plant material represents an excellent opportunity for deciphering the basis of early-flowering in apricot and to speed up the long-term breeding process for precocity as there is need to introgress other traits. PrunMut is aimed at (1) generating genomic resources for the identification candidate casual mutation in the two apricot mutants ‘Rojo Pasión Precoz’ and ‘Búlida Precoz’, also useful apricot breeding programs; (2) identifying candidate causal mutations of early flowering in the two mutants and shed light on mutation rate in this species; (3) evaluating the impact of the candidate casual mutation and give cues on the control of flowering date in the two mutants and (4) transfer of result for breeding and functional genomics. To develop markers for Prunus breeding programs aimed at early/late flowering date and to build collaborations for future functional genomics validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adolescents, Parents and Digital Media: Looking for the pattern that dis/connects' (AdoDigitFamX).

assistant: **Concept**

This project will use a trans-disciplinary framework of social and developmental psychology and media and communications and the innovative methods of the First Person Perspective and Digital Ethnography to address existing gaps in research into the use of Information Communication Technologies, child development and family communication. Commenting upon research in the field, the recent report www.eukidsonline noted a prevalence of studies based on quantitative methods and a neglect of focus on mobile, convergent and emerging technologies. It also identified a persistent focus on risks and harm rather than opportunities and benefits and the lack of information on the role of adults, safety mediation and their effectiveness. This project fills these gaps by: (1) capturing the actual practices of adolescents with ICTs; (2) understanding how ICTs, family communication and parenting mutually shape one another; (3) exploring the opportunities and risks of ICTs for family and child development and the role of parents as safety mediators. A minimum of ten families with at least one adolescent child aged 13-16 will be recruited through Italian secondary schools to participate in the research which will involve data gathering via micro cameras (subcams) and video-interviews. Our innovative methods will provide new knowledge on: parents’ and adolescents’ individual and interpersonal practices in relation to ICTs; the goals, motives, representations and emotions underlying these practices and ICTs mediation processes in everyday family life. The implications of ICTs use for families and children’s health will also be considered. The results will be disseminated to socio-educational and clinical agencies, policy makers, and the general public. The fellowship will be  hosted by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Potential Antimalarial and Anticancer Lead Compound Discovery from Cameroonian Medicinal Plants' in the context of a Seventh Framework call.

assistant: **Objectives**

Cameroon enjoys a rich biota including a plethora of medicinal plants, which have traditionally been used for hundreds ofyears to treat various ailments, and form the basis of the country’s primary healthcare system. Medicinal plants of thegenera Fagara (F: Rutaceae), and Hannoa and Pierreodendron (F: Simaroubaceae) belong to the Cameroonian flora, andare used by the local people to treat malaria, cancer, rheumatism, bacterial infections, pain, inflammations, typhoid, skininfection and other serious disorders. Previous studies carried out on certain species of these genera afforded variousphytochemicals (quassinoids, furoquinoleine, acridones, cathinone alcaloids, triterpenoids and steroids) and revealedinteresting pharmacological properties (cytotoxicity, antiplasmadial activities). This project proposes to employ acombination of chemical fingerprinting-based dereplication, assay-guided fractionation and reversed-phase preparative highperformance chromatographic methods to identify potential anticancer and antimalarial lead compounds from plants of thegenera mentioned above, selected on the basis of ethnobotanical information as well as literature data. The structures ofthe isolated compounds will be elucidated by spectroscopic means (UV, IR, MS, NMR and X-ray). Structural modification toincrease activity of compounds will be carried out applying modern semisynthetic approaches in order to establish structureactivityrelationships. Total synthesis will also be carried out to increase to quantity of the lead compounds. Suitable in vitrobioassays, relevant to cytotoxicity, antimalarial and toxicity determination will be utilised to aid isolation processes as well asfor the determination of bioactive potencies of the isolated lead compounds. The main objective is to discov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Characterisation of the mechanism of anchoring of specific localized transcripts in Drosophila'.

assistant: **Innovation**

mRNA localization by active transport is thought to be a universal mechanism to target proteins efficiently to their site of function. Localized RNAs are transported to their destination by molecular motors that move along the cytoskeletal filaments, followed by retention at their final destinations.Several molecular motors, adaptors and trans-acting factors involved in the movement itself have been identified, but the mechanism of anchoring remains poorly understood. In the proposed project, we will use a rapid in vivo assay, which consists of injecting fluorescently labelled RNAs in Drosophila oocytes and embryos and imaging their movements by time-lapse video microscopy. Firstly, we will determine whether mRNA localization depends on anchoring at its site of localization or alternatively involves continuous active transport.To achieve this aim, we will assess whether microtubule-inhibiting drugs' and reagents' disrupting function of molecular motors affect RNA localization. If the maintenance of RNA localization is not MT motor dependant, we will determine what the intracellular structures are, and the molecular basis of retaining the RNA at the site of localization.We will characterise RNA anchoring in mutants for candidate genes. In parallel, we will map RNA signals required for anchoring and identify the transacting factors that bind to the signals using biochemical methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Non-Conventional Wave Propagation for Future Sensing and Actuating Technologies' to be submitted under Horizon 2020.

assistant: **Abstract**

New sensing devices and technologies are the key in addressing numerous challenges that agriculture is facing today. Namely, to provide more food for the ever-growing population, a number of biophysical parameters of plants, soil and food products need to be monitored and measured constantly, thus providing valuable data needed to optimize the entire agricultural process. In addition, the corresponding actuating technologies responsible for applying various measures (e.g. irrigation, fertilization) need to become more precise and allow variable rate inputs with a resolution down to an individual plant.To provide novel sensing and actuating solutions able to address the burning issues in agriculture today, NOCTURNO will bring together and synergistically advance several highly promising research directions which have been investigated separately in the last decade: wave-matter interactions, plasmonics, complex media and artificial materials, acoustic, electromagnetics, optics, bionanosensing.The Project will focus on development of sensors and actuators based on non-conventional propagation of acoustic waves in artificial media, electromagnetic/optical sensors based on metasurfaces, and advanced manufacturing technologies including 3D printing, laser-micromachining technology, and e-beam lithography with the aim to provide practical solutions for the fabrication of novel acoustic and metasurface-based sensors and actuators.NOCTURNO proposes an exchange programme which brings together three European academic institutions, two European SME companies, and two third-country universities. The consortium has the specific expertise in the fields listed above and it will create synergies that will first advance the current level of fundamental scientific knowledge and then suppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ACcelerating Transition in Peri-Urban areaS in East Africa' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Behind statements and statistics about newly urbanized populations in Africa, behind maps of rapid and unregulated growth and numerous disaster/risk assessments there are real people with compelling tales of coping and adapting capacities to urban challenges brought by the rapid transformation of cities. Their stories often contain more hope, ambition and imagination as portrayed in reports and scientific publications. Their ability to bounce back despite disadvantageous ecological, economic and political settings implies a new form of normality framed outside traditional city development models.ACTUS is concerned with people's everyday experiences of solid waste and sanitation in peri-urban areas to discern the interdependences between urban infrastructure, pro-poor growth and climate hazards. In ACTUS I place a particular focus on local processes of adaptation and self-organization to cope with increasing flooding impacts in East Africa. The lens of everyday experiences of waste management and sanitation offers an innovative approach to expend our understanding on multiple spheres of livelihoods considering how local processes and technologies may act as a benefit for the poor and may trigger sustainable technical infrastructureACTUS is not a 'stand alone research project. It is designed to run complementary to a PhD program on 'Urban Infrastructure in transition: The case of African cities from the Graduate School of urban Studies at TU Darmstadt. The benefit of such close collaboration lies in the breath of knowledge I will gain not only within my specific research project but also through regular exchanges with a multidisciplinary group of scholars focusing on urban infrastructure regimes in Africa.