RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Plant Cytoskeleton in Development' (CYTOGREEN) targeting Sixth Framework.

assistant: **Abstract**

Plants are unique in many aspects of their biology. In particular, the cytoskeleton is at the centre of many cellular activities essential for cell division and elongation, but also for differentiation and multi-cellular development. It adopts several various spatially independent arrays unique to plant cells. Besides fundamental questions, all aspects of plant development, including its cellular bases, are of interest for agriculture and plant breeding. In this proposal, a combination of approaches in molecular genetics, biochemistry and cytology aims at understanding the function of a novel family of Arabidopsis proteins (TIMs) involved in the dynamics of the cytoskeleton. These proteins were isolated from an interaction screen with the TON protein as bait; mutations in TON genes abolish formation of the preprophase band of microtubules, a structure involved in the positioning of division planes in land plants.TIM17 was recently shown to be dually targeted to both microtubules and actin filaments. Less than a handful of such proteins have been characterised in plants, and TIM proteins could be part of the elusive molecular link between the two tightly correlated networks. The research project aims at understanding the function of these proteins and their localisation in a cell, as well as the molecular bases for this dual targeting and the nature of their interaction with TON. During his PhD work in India, AM Prasad has acquired a strong background in plant biology and molecular genetics, including practical experience on Arabidopsis.Of special interest to him will be training in key concepts and methods of plant cell biology and proteomics, which have undergone tremendous changes in the last decade; this will complement his repertoire of skills and be highly benefici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Biodiversity in the seas is only partly explored, although marine organisms are excellent sources for many industrial products. Through close co-operation between industrial and academic partners, the MAREX project will collect, isolate and classify marine organisms, such as micro- and macroalgae, cyanobacteria, sea anemones, tunicates and fish from the Atlantic, Pacific and Indian Oceans as well as from the Mediterranean, Baltic and Arabian Seas. Extracts and purified compounds of these organisms will be studied for several therapeutically and industrially significant biological activities, including anticancer, anti-inflammatory, antiviral and anticoagulant activities by applying a wide variety of screening tools, as well as for ion channel/receptor modulation and plant growth regulation. Chromatographic isolation of bioactive compounds will be followed by structural determination. Sustainable cultivation methods for promising organisms, and biotechnological processes for selected compounds will be developed, as well as biosensors for monitoring the target compounds. The work will entail sustainable organic synthesis of selected active compounds and new derivatives, and development of selected hits to lead compounds. The project will expand marine compound libraries. MAREX innovations will be targeted for industrial product development in order to improve the growth and productivity of European marine biotechnology. MAREX aims at a better understanding of environmentally conscious sourcing of marine biotechnology products and increased public awareness of marine biodiversity and potential. Finally, MAREX is expected to offer novel marine-based lead compounds for European industries and strengthen their product portfolios related to pharmaceutical, nutraceutical, cosme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CONFIRMING THE SUITABILITY OF THE ORGANIC METHOD OF PROTECTION WITH TRICHOGRAMMA BRASSICAE FROM THE MAIZE PYRALID' (TRANSBIOCORN) targeting Fourth Framework.

assistant: **Abstract**

The project proposes breeding and identification of the most suitable Trichogramma strain for field applications in Southern Europe environments. - Full field testing of farms specialised in sweet corn crops and other crops. - Technical and economic validation of biological material distribution based on farm characteristics. - A programme of dissemination and commercial enhancement of biological treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The charm of asymmetries or the asymmetries in charm (entangled edition)'.

assistant: **Concept**

The study of difference between matter and antimatter (CP violation) is one of the most exciting fields at the frontier of fundamental physics research. It is driven by the question of what happened to the antimatter after the Big Bang. The mesons, particles that contain both matter and antimatter quarks are ideal laboratories for the discovery of CP violation. This proposal aims at looking for CP violation in decays of mesons containing one charm (or anti-)quark, the only type of mesons where CP violation has not yet been observed.One of the objectives is to carry out a measurement of the matter-antimatter mixing and CP violation parameters in the most sensitive charm decay mode (D0->Kspipi) using the unprecedented charm data sample collected by the LHCb experiment at CERN. To achieve maximal precision of both measurements, external input from the unique Chinese flavour factory, BESIII, is crucial. Key attributes of the decays of the D meson, the strong phases and their variation across the phase space, require the use of quantum-entangled states that are accessible at BESIII. Usually, these quantities are measured in regions of the phase space, the definition of which is inspired by a model. Wrong definition of these regions would lead to dilution of the sensitivity of these measurements. We propose to measure these quantities at every point of the phase space to maximise the precision. The second objective is to look for CP violation in the charm D0->(anti-)K*0KS decays with LHCb data ignoring time-dependent effects arising from matter-antimatter mixing. The three-body final state after an instant decay of the exited K*0 meson, K pi KS, will be studied using novel model-dependent and model independent methods, the former has been pioneered by the Manchester LHCb grou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'PHYsics for a greener world: fostering the NExt generation of talented young researchers in novel materials, innovative STrategies and energy solutions'.

assistant: **Innovation**

PHYNEST (“PHYsics for a greener world: fostering the NExt generation of talented young researchers in novel materials, innovative STrategies and energy solutions"") is a unique doctoral programme for talented 25 PhD candidates, led by Universitat Autònoma de Barcelona (UAB). PHYNEST aims to train tomorrow’s leaders in the field of advanced materials, innovative strategies, and key solutions to help migrate towards a new energy paradigm and to enhance environmental sustainability, taking physical sciences as the backbone. Together with UAB, 5 internationally-renowned research centres as Implementing Partners will embark on this exciting adventure after selecting and recruiting doctoral candidates from all over the world in an open, transparent and merit-based process. Special attention will be paid to applications from women, which have been chronically underrepresented in STEM disciplines, and other minority groups. Cutting edge research topics will be offered to the PhD candidates (+50 options) in which experimental and theoretical research, as well as the historical and social dimension of energy and climate, will be tackled in a highly collaborative, multidisciplinary and innovative manner. The hosting institutions count with world-class research infrastructures and a pool of accomplished supervisors in their respective fields. +20 Associated Partners will participate in PHYNEST to host the fellows for secondments and/or participate in the network-wide events of the network to offer high-quality scientific and transferable skills training in different domains, ranging from diversity equity and inclusion, time and project management, to effective communication to diverse audiences. PHYNEST is the perfect nest for nurturing young researchers, preparing them to become t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tailoring growth and opto-electronic properties for organic nanoscale semiconductor devices' (TOPOS) targeting Sixth Framework.

assistant: **Abstract**

TOPOS addresses a deeper understanding of growth processes of organic films with the aim to develop nano-scale organic field-effect transistors (i.e. transistors with source-drain inter-electrodes distance varying from hundreds to a few nanometres). Fabrication of nano-scale organic field-effect transistors (OFET) is an attractive and challenging task involving both technological and fundamental issues. Our approach to nano OFET fabrication combines a sophisticated nano-scale fabrication technique, i.e. e-beam lithography, adopted to engineer the device at the nanoscale, with the unique ability of Supersonic Molecular Beam Epitaxy (SuMBE) to control morphology, structure and interfaces of molecular organic layers. Such combination of up to date methods is uniquely suitable to thoroughly study the key factors determining the performance of the nano-transistors and hence for determining strategies towards new generations of devices.Our tasks involve: choice of the semiconductor material, optimisation of the growth of the organic active layer, selection of dielectric and electrode(s) material, substrate processing and patterning. We expect that our project will give a boost to the state-of-the-art of OFETs. Merging of two highly capable techniques (e-beam lithography and SuMBE) will enable the fabrication of well-defined and controlled samples, a critical key to improve our fundamental understanding of device physics at the nano-scale. In particular optimisation of nano-electrodes and tuning of the active layer morphology will make possible the study and the optimisation of device performance as a function of the channel length, including exploration of electrical properties down to the molecular level. This is something that is very much required by the organic electronic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sea2Sky : Linking Marine, Atmospheric and Astronomical Researchers to the General Public' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Marine, Atmospheric and Astronomical sciences readily lend themselves to promoting science and the role of researchers to the general public. In 2011 we had a very successful Researchers Night with over 10,000 attendees and publicity which reached at least half a million people both locally and nationally. Building upon this success we would like in 2012 to extend our activity to link with Blackrock Castle Observatory in Cork and to participate in the 2012 City of Science Dublin. Given our success last year we do not want to change our approach albeit learning from some of the problems we encountered last year. This year the look of the event will be different and designed to encourage as much participation as possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficient removal and recycling of nitrogen from organic waste as fertiliser' (NIREC).

assistant: **Innovation**

The technical objectives of the project are to: develop a new sustainable technology for nutrient recovery and recycling from anaerobic digesters, which concurrently enhance the anaerobic digestion process. It also aims at the maximum valorisation of all residuals and to convert them into a marketable product, with standard quality specifications. It will develop, combine, scale up and test the different components and techniques of the processes to obtain a totally integrated solution. When the solid part of the anaerobic effluent is composted the liquid part is recycled and the valuable compounds are sold, this process targets for a zero emission solution.The technical program contains 8 Work Packages (WP), each addressing the main technological aspect. It starts with the pre-treatment of the substrate devoted for anaerobic digestion; another major activity is the development of a technical solution allowing stripping the ammonium directly in front or out of the anaerobic digester and it deals with the emerging odour emission from a waste treatment plant. It includes, a legal/economic WP dedicated to strengthen the acceptability of the developed process, and to fortify the potential end-users´ position. The proposed work will be fulfilled in a framework of advanced management. Laboratory work will be carried out to develop new technical solutions.The results will be used to design a pilot unit integrating all aspects investigated. After construction and start-up, a comprehensive evaluation with the pilot unit will be performed at a SME. The project has an important process dissemination and exploitation component including a strategy for market introduction assured by legal and economic assessment and evaluation of the results. The cooperation between 4 SME and 1 end-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Non-Animal Platform for Nanoparticle-Based Delivery across the blood-brain barrier Interface with Vehicle Evolution' (NAP4DIVE) targeting Horizon Europe.

assistant: **Abstract**

The blood-brain barrier (BBB) is a major obstacle in treating diseases of the central nervous system (CNS) such as Parkinson's, Alzheimer's, Schizophrenia and brain cancer, affecting 180 million Europeans with less than 5% of current candidate drugs effectively reaching the brain. NAP4DIVE strives to revolutionize the traditionally expensive and inefficient drug development for these diseases by establishing advanced non-animal alternatives for testing and predicting nanoparticle (NP)-based drug delivery across the human BBB. This approach aligns with EU and global initiatives to reduce animal testing and advance human-based biomedical research models. The project will develop two complementary non-animal tools: a high-throughput BBB-on-Chip and an in silico model based on machine-learning (“NP Design Simulator”). A digital repository of optimized nanoparticle designs “NP Design Library” will be created to gather publicly available and newly obtained NP characterisation data, specialised for BBB delivery. The Design simulator screens thousands of NP designs to recommend the most promising ones, which will be tested in vitro on the microfluidic BBB-on-Chip with real-time measurement of barrier integrity. The accuracy and physiological relevance of both tools will be validated by the pharmaceutical partner through comparison with clinical and pre-clinical data. NAP4DIVE tools will reduce animal use in CNS drug development by up to 95% while saving 30 % of costs. By identifying nanoparticles for cross-BBB drug delivery and offering avenues for new effective treatment options, NAP4DIVE addresses one of the most pressing healthcare challenges of the century. A comprehensive HTA will demonstrate market readiness and cost-effectiveness of the tools, an ethical assessment will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Value Omega 3 and Astaxanthin products from SeaAlgae' in the context of a Horizon 2020 call.

assistant: **Objectives**

Omega-3 is an essential oil required by the body for proper functioning. It protects from cardiovascular diseases andimproves the development and functioning of the skin as well nervous and visual system. Astaxanthin is a carotenoidpigment and is one of the most effective antioxidants to support human health.The global demand for Omega-3 and Astaxanthin for human consumption will require large quantities of both products:260.000 tonnes of Omega-3 and 670 tonnes of Astaxanthin per year. This growing demand comes mainly from healthconscious customer segment. This segment is also very interested in buying natural and eco-friendly products. However,their traditional extraction process from marine organisms (mainly fish and krill) is not sustainable: over fishing, high energy,raw materials consumption and a low efficiency. The majority of the marine resources are fully exploited or overexploited.The SME Neoalgae has designed an eco-innovative and sustainable industrial bioprocess for obtaining Omega-3 andAstaxanthin using marine microalgae as a natural source. This system is the answer to the growing demand in Omega-3 andAstaxanthin, especially in nutraceutical, cosmetic and pharmaceutical applications. With the new process, production ofOmega-3 and Astaxanthin will not affect marine resources. Both products will be free of pollutants, without fishy aftertasteand odour free, apt for vegans, and with competitive and stable production costs.After the feasibility of the new products has been proved at a technical and market level, this SME-2 project will scale-up theproduction of both compounds and will demonstrate their effectiveness through their inclusion in nutraceuticals and in newecological products for the treatment of 3 skin diseases: acne, atopic skin and aging skin pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unraveling nanosecond motions in nucleic acids with high-resolution relaxometry: how dynamic is nicked DNA?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

What role do conformational dynamics play in DNA function and repair? Structures of DNA show local dynamics, conformational flexibility of bases, and large conformational changes in the double helix, indicating easily accessible motions. Yet studying fast motions in nucleic acids is challenging. To address this we will introduce High Resolution Relaxometry (HRR) and apply it to study single strand breaks (SSBs) in DNA.  Nucleic acids are often studied at atomic resolution with X-ray crystallography and high-field Nuclear Magnetic Resonance (NMR). Yet neither is suitable to study ns-motions. X-ray crystallography does not report on dynamics while using high-field NMR leads to high resonance frequencies so little ns time-scale information is present. This presents a challenge: how to characterise fast motions in nucleic acids?  We will develop a new methodological approach, HRR, to probe ns-motions in DNA. HRR was developed by the host team to study ns-motions in proteins. We will adapt these methods to investigate motions in DNA. We will compare dynamics occurring in intact DNA, DNA with a SSB and SSB DNA with a missing base. Understanding the motions in each DNA construct will establish the effects that each type of DNA damage have on the motional properties of DNA. This will elucidate how each type of damage affects the base pair stacking and the motions occurring at the breakpoint.  Understanding the flexibility induced by DNA damage will have a significant role in understanding DNA repair and how damaged DNA is recognised. The DNA repair protein, PARP-1, is a cancer-drug target and recognizes SSBs. Our final objective is to uncover the role of DNA motions in SSB recognition by PARP-1.  In summary we will develop HRR as a new method to investigate ns-motions in DNA, p