RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Explicitly Normalized ImaGing MAss Spectrometry', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Imaging Mass Spectrometry is a rapidly developing technique that uses spatially resolved proteomic techniques to investigate a tissue’s biomolecular content. Imaging MS of pharmaceuticals has demonstrated that relative quantitation can be obtained if the MS response factors are known. However MS response factors for peptides and proteins are highly dependent on their exact nature. Despite it being acknowledged as the single biggest factor limiting the clinical application of the technique, to date it has remained an enigma how imaging MS analyses may be explicitly normalized to enable relative quantitation because it would require the relative response factors to be determined for every peptide/protein.Here I will develop a methodology for the explicit normalization of every protein detected during imaging MS experiments. This will utilize the recently released SILAC mouse to create a reference standard in which all lysine residues are replaced with 13C6-lysine. Tryptic digestion of SILAC protein extract creates tryptic peptides containing a single 13C6-lysine, which can be used as a reference standard for the 12C6-lysine containing peptides created by on-tissue digestion of normal mouse tissue.Ultrahigh mass resolution imaging MS will be used to ensure all tryptic peptides, and their 13C6-lysine reference standards, are resolved enabling the images of all tryptic peptides to be normalized using their own isotopically labelled analogues. The quantitative capabilities will be determined for every tryptic peptide ion detected from mouse brain tissue.The capabilities of this ENIGMAS strategy (Explicitly Normalized ImaGing Mass Spectrometry) will be used to investigate the spatial and temporal evolution of the proteome perturbations that follow migraine. Multiple measuremen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Strengthening of the MagBioVin Research and Innovation Team for Development of Novel Approaches for Tumour Therapy based on Nanostructured Materials'.

assistant: **Concept**

Through the realization of MagBioVin project, the Institute of Nuclear Sciences “Vinca”, University of Belgrade (Serbia) receives important community support to upgrade its capacities related to the highly specialized research on activated magnetic nanoparticles (MNP) and radionuclide labeled magnetic nanoparticles for application in biosciences, pharmacy and medicine. This is planned to be realized by a set of comprehensive actions, such as engagement of eminent expert in the field (ERA Chair holder), bringing experimental facilities up to the most advanced EU-competitive level, cutting-edge trainings in reputable EU research institutions and intensive dissemination towards ERA, Universities and stakeholders. The Project foresees the key role of ERA Chair holder in improvement of organizational structure, research excellence and especially in communication with stakeholders. Organization of seven dedicated international workshops led by EU experts in the field, six extensive training programs for MagBioVin team members and the accent on intensified international collaboration, are few of the activities anticipated through Project implementation. These are designed to set solid foundations for a final goal: to rise both human and experimental capacities of the “Vinca” Institute to the level that ensures considerable scientific and technological impact within ERA and its ability to compete with leading EU research institutions on an equal basis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigation of the remobilization of lanthanides and actinides during fluid-mineral interactions - development of the necessary in-situ analytical techniques' under Fourth Framework.

assistant: **Concept**

This project aims at: a) A better understanding of the behaviour of lanthanides, actinides and their isotopes within selected accessory minerals when these undergo fluid-rock interactions and; b) The development of the analytical tools used (i.e. mainly the Laser Ablation-Inductively Coupled Plasma-Mass Spectrometer (LA-ICP- MS), and the Thermal Ionisation Mass Spectrometer (TIMS)). Both parts will build upon what has already been achieved during a HCM fellowship. An improved knowledge of the hydrothermal mobility of these elements will help 1) to trace and date the fluids within the earth's crust, and 2) to assess the suitability of monazite or sphene-like ceramics as nuclear waste forms. The reduction of elemental fractionation and the improvements of the precision in isotope ratio measurements by LA-ICP-MS, together with the enhancement of the spatial resolution of TIMS will be of benefit for the scientific and industrial users of these techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Integrating Genomics and Avatar Mouse Models to Personalize Pancreatic Cancer Treatment'.

assistant: **Innovation**

The prognosis of patients with metastatic pancreatic cancer (PDAC) is very poor. Recent studies have started to elucidate the genetic landscape of this disease to show that PDAC is a genetically complex, unstable, and heterogeneous cancer. However, in-depth analysis of individual patient genomes couple with personalize Avatar mouse models is providing highly effective therapeutic opportunities for the individual patient. Thus, metastatic PDAC appears a candidate disease to implement a genomics-base, personalized treatment approach. In this project, we will conduct an open label, multicenter, randomized phase III study in patients with standard of care resistant metastatic pancreatic cancer aiming to test the hypothesis that an integrated personalized treatment approach improves survival compare to a conventional treatment.  Patients randomized to the personalize treatment arm will undergo a biopsy of a metastatic lesion to perform a targeted genome analysis using next generation sequencing. In addition, we will generate a personalize Avatar mouse model from the same patient. We will employ sophisticated bioinformatic analysis as well as mining of drug response-genetic databases to select, for each individual patient, candidate therapeutic targets that will be experimentally tested in the patient´s Avatar model to select the most effective regimen that will ultimately applied to the patient.  In addition, based on the genomic data, we will design an individualized monitoring plan for each patient using BEAMing technology to monitor circulating levels of mutated genes. Furthermore, with a discovery goal, we will perform in depth genomic analysis of metastatic PDAC lesions in this cohort of clinically well-annotated patients with Avatar mouse models for therapeutic validat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TRANS-EUROPEAN NETWORK INTERCONNECT AT 34 MBPS' under Fourth Framework.

assistant: **Concept**

TEN-34 will validate the interconnection of national research and university networks which are already offering high-speed data transfer services, at speeds which will improve the quality of multi-media applications across Europe. TEN-34 will apply new, flexible and powerful technology (Asynchronous Transfer Mode, ATM - see JAMES). The new network will be connected to existing research networks in Europe, so that European cohesion is maintained.This project aims to deploy trans-European networking facilities which will provide complementary international capacity to allow the national research network investments to be exploited on a global basis and maintain the competitiveness of European research. The technical implementation of a high speed network for research needs to address both the requirements for greater capacity and for support of the emerging multi-media applications. Implementation will be phased, both in terms of geographic and functional roll out.An important criterion for the selection of the networking technology is that it be sufficiently stable to provide real service to a community of innovative users, yet sufficiently leading edge to ensure applicability throughout the four year planning period, and that it is able to interwork with the services being deployed nationally.There are major developments in telecommunications technology that will be implemented over the next four years. The most significant is the introduction of Asynchronous Transfer Mode (ATM) switching. ATM promises a number of benefits in terms of performance and manageability, particularly for the emerging multi-media applications. It is, however, not yet a mature technology and will continue to develop. A two part approach to implementation is therefore proposed consisting of: -
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From the Planck Scale to the Electroweak Scale' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The quest for a unified theory of all fundamental interactions (electroweak, strong and gravitational), going beyond the so-called Standard Model of particle physics, has entered a crucial phase. The phenomenological studies of possible signals of new physics, at particle accelerators and elsewhere, have reached a high level of technical development and reliability, especially in the field of supersymmetric extensions of the Standard Model, but still lack some firmer guiding principles. The field-theoretical studies of string theories and their generalizations, the present best candidates for a unified quantum theory of all the interactions (including gravity), have witnessed impressive developments in the last few years, with the development of new concepts such as non-perturbative dualities, D-branes, but the phenomenological impact of these developments has not yet been worked out. We feel that the promotion of the cross-talk between these two apporaches is crucial to keep both of them healthy and to maximize their scientific output.The two high-level conferences being proposed want to achieve this goal by focussing on two hot and closely related topics in the present agenda of theoretical high-energy physicists: the flavour problem and the problem of super-symmetry breaking.The aims of the two meetings are the following:- defining the state-of-the-art of the different facets of the two problems, both on the theoretical and on the experimental side;- promoting the exchange of information among the specialists of different approaches (from the more mathematical to the more phenomenological) and exploring the possibility of fruitfully combining some of them exploring the links between the flavour problem and the problem of super-symmetry breaking, possibly identifying
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Judicial Conflict Resolution: Examining Hybrids of Non-adversarial Justice'.

assistant: **Concept**

In the past few decades, the role of judges has changed dramatically and its nature has remained largely unexplored. To date, most cases settle or reach plea-bargaining, and the greater part of judges’ time is spent on managing cases and encouraging parties to reach consensual solutions. Adjudication based on formal rules is a rare phenomenon which judges mostly avoid. The hypothesis underlying JCR is that the various Conflict Resolution methods which are used outside the courtroom, as alternatives to adjudication, could have a strong and positive influence, both theoretical and practical, on judicial activities inside the courts. Judicial activities may be conceptualised along the lines of generic modes of conflict resolution such as mediation and arbitration. Judicial conflict resolution activity is performed in the shadow of authority and in tension with it, and crosses the boundaries between criminal and civil conflicts. It can be evaluated, studied and improved through criteria which go beyond the prevalent search for efficiency in court administration. Empirically, JCR will study judicial activities in promoting settlements comparatively from a quantitative and qualitative perspective, by using statistical analysis, in-depth interviews, mapping and framing legal resources, court observations and narrative analysis. Theoretically, JCR will develop a conflict resolution jurisprudence, which prioritises consent over coercion as a leading value for the administration of justice. Prescriptively, JCR will promote a participatory endeavour to build training programs for judges that implement the research findings regarding the judicial role. Following such findings, JCR will also consider generating recommendations to change legal rules, codes of ethics, measures of eval
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MeAsurement of Gravitational effects on photonIc QUantum systEm' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The interplay between the two main pillars of physics ─ quantum mechanics (QM) and general relativity (GR) ─ has never been understood or tested by scientists, and this has become one of the most important, interesting and challenging research areas over the past decades. So far there is no experiment demonstrating how gravity affects unique quantum features, e.g. superposition and entanglement. This project is aimed to combine quantum interference and GR in a single table-top experiment using Mach-Zehnder fiber interferometry. Single photons and entanglement states will be employed to investigate how gravity alters quantum correlations and superposition of massless particles.It would be a great scientific breakthrough to demonstrate gravitational-induced effects on single photons and quantum states, paving the way for quantum gravitational lab-scale experiments. This project will push large-scale high-precision single photon interferometry to a new level, leading to the development of cutting-edge techniques from various disciplines ─ quantum photonics, precision interferometry, frequency metrology, etc. This study is timely and highly relevant to the current EU research trends, going in line with the prioritized research directions of Horizon Europe: quantum technologies and time & frequency services.This project will be implemented in the group of Prof. Philip Walther at the University of Vienna. The host group expertise in quantum control and their state-of-the-art single photon facilities perfectly complements to the Researcher Dr. Yu’s background in interferometric gravitational wave detection and macroscopic QM phenomena. This Fellowship will enable the two parties to combine their skills and achieve the major scientific goals. Furthermore, this Fellowship will g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of microglial cells during neurodegeneration in Amyotrophic Lateral Sclerosis' (2007-2013).

assistant: **Concept**

Amyotrophic Lateral sclerosis (ALS) is an adult-onset neurodegenerative disease affecting motor neurons and leading to paralysis and death of the patients. Missense mutations in the gene for the ubiquitously expressed Cu/Zn superoxide dismutase (SOD1) are the best known cause for familial ALS leading to motor neuron death through an acquired toxic function still unidentified. Mice expressing ubiquitously mutant SOD1 develop ALS and although paralysis arises from death of motor neurons it is now clear that different, especially glial, cell types expressing mutant SOD1 contribute to the disease mechanism. Indeed, we have shown that microglial cells, the macrophage of the central nervous system, are implicated in the progression of the disease. Microglial cells originate from hematopoietic cells that colonize the CNS during development, have both neurotrophic and neurotoxic capabilities and are the first cell type to react to any kind of lesion in the CNS including familial and sporadic ALS. With this project I would like to go a step forward in understanding how microglial cells are implicated in motor neuron degeneration. Therefore, the objectives of this project are to study the interactions between macrophages/ microglial cells and motor neurons in ALS mouse models with the aim of increasing motor neuron survival and improving symptoms of the disease. In particular, we want to address (1) the mechanisms of microglial neurotoxicity, especially excitotoxicity, (2) the signals coming from motor neurons that could attract microglial cells and (3) the participation of the peripheral macrophages (macrophages in peripheral tissues and the ones infiltrating the CNS) to motor neuron degeneration in ALS models. As microglial cells are activated both in familial and sporadic ALS,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Crest'.

assistant: **Objectives**

The CREST project is proposed by WEGEMT: A European Association of 37 universities in 19 countries with expertise in a broad range of marine matters. The events are developed in conjunction with universities, who take an active role in ensuring the quality of the events in terms of their delivery and content. WEGEMT's Secretariat provides the coordinating function so that local hosts can concentrate on the task of delivering a technically sound event.The Secretariat also acts on behalf of the WEGEMT Executive Committee that takes ultimate responsibility for the delivery of these events. WEGEMT has been involved in discussion of major strategic issues affecting R&D and training in Europe for marine Industries. Its aim is to update and extend knowledge and its mission stresses the need to deliver collaborative solutions. The events described in this application are ideal vehicle to achieve this mission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International Interdisciplinary PhD studies in Biomedical Research and Biostatistics. Supporting the career and training in omic-based research and biostatistics by inter-national and-sectoral mobility' (ImPRESS).

assistant: **Innovation**

The aim of the project is to launch Interdisciplinary PhD Studies in Biomedicine aimed at young aspiring scientists, who will conduct research on life-style diseases and on biostatistics and bioinformatics methods necessary to process and interpret data obtained in research projects. The studies will provide an outstanding opportunity for in-depth education in high-throughput experimental and computational techniques used in genomics, proteomics, metabolomics and immunology. 15 PhD students will be involved in scientific projects supervised by excellent researchers, outstanding scientists selected from partner organizations, with a profound expertise and experience in: Cancer/Mutagenesis, Cardiovascular diseases, Population Medicine and Epidemiology, Diabetes/Obesity, Metabolic and Neurodegenerative diseases, Regenerative medicine, Molecular Biology, Genomics, Protein Analysis and Proteomics, Metabolomics/Lipidomics, Immunology and Experimental Medicine. They will be employed at Medical University of Bialystok. The development of doctoral students' research potential will be based also on internships, short research visits, conferences and trainings at the partner institutions: CEMBIO San Pablo University, Vienna Biocenter, Spanish National Center for Cardiovascular Research CNIC, Bialystok University of Technology and CenStat at Hasselt University. Industry partner organizations: Agilent Technology, deCODE, ideas4biology and Warsaw Genomics will invite PhD students for scientific visits, to familiarize young researchers with the tools and methods of work and organizational environment in the company. Industry providing their know-how will educate, and prepare their potential employees with high qualifications to get job in the close future. Best young scientists from t