RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design, synthesis and biological evaluation of new selective 5ht7, agonists using combinatorial chemistry, automated organic synthesis and molecular modelling' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content Our main objective is the design and synthesis of selective 5TH7 agonists. A selective 5TH7, agonist will be very valuable to investigate de effects of 5TH7 receptor stimulation and to provide biological verification methods, both in vivo and in vitro for investigation of 5TH7, antagonists that could be used as psychoactive drugs in psychiatric disorders like depression, anxiety or schizophrenia. The project includes the following points: - Design of potential selective 5TH7 agonists libraries using the Chem-X molecular modelling suite. - Synthesis of the designed compounds (between 300 and 800 molecules) using combinatorial chemistry and automated organic synthesis techniques. - Test the synthesised libraries as 5HT7 agonists. - Successful ligands will be subjected to a modified Irwin behavioural screen in order to identify SELECTIVE 5HT7 agonists. - Full receptor binding scans of the most promising molecules and evaluation of their in vivo activity.By using combinatorial chemistry and automated synthesis we will synthesise a huge number of molecules that increase the probability of success with lower costs. Training content (objective, benefit and expected impact) My main training objective as a medicinal chemist is to learn combinatorial chemistry and automated organic synthesis. Both methodologies are very important in pharmaceutical, agrochemical and biotechnology industries to reduce the time and costs associated with producing effective, marketable and competitive new drugs. I will also develop my knowledge in molecular modelling using the Chem-X molecular modelling suite. Links with industry / industrial relevance (22) Although the project has no links with industries, the results obtained could be used by pharmaceutical industrie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular Dissection of Immunomodulatory Function of Polysaccharides', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Edible polysaccharides from plants and microbes have attracted attention because of their potential functions to improve our health. Although several polysaccharide products have been commercialized, the mechanism by which such polysaccharides benefit our health is yet unclear. I hypothesize that such polysaccharides may modulate the immune function through interaction with the glycan-binding protein (GBP) receptors on immune cells.To prove the hypothesis, I will take a multidisciplinary approach involving immunology and biology of carbohydrates (glycobiology). My aims are: (1) to evaluate the effect of polysaccharides on primary human and mouse immune cells; (2) to analyse the interaction between polysaccharides and the immune cells in vivo by state-of-the-art flow cytometry; (3) to identify the GBP partner for each polysaccharide by a facile reporter assay system. This research will deliver crucial knowledge on how polysaccharides function, and the potential impacts are far-reaching as the results will inform the design, development and efficacy-testing of potent novel carbohydrate-based foods, therapeutics and healthcare products.Since I am building my independent research group at the host, Institute for Food Research in UK, I will have outstanding opportunities to transfer my knowledge and expertise from Japan and the USA to the UK and Europe. My scientific expertise and experimental approaches in biology of carbohydrates (glycobiology) and immunology will be integrated through proactive collaboration with other groups, mentoring young scientists, presenting at scientific conferences, publications and through public outreach activities.Mutual transfer of knowledge will build a dynamic multidisciplinary research platform to elucidate the bioactivity of polysaccharid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Brains that fire together wire together:  Interbrain plasticity underlies interaction-based learning' (INTERPLASTIC) targeting Horizon 2020.

assistant: **Abstract**

Traditionally, brain plasticity was viewed as a change occurring in synapses, brain structures and functional networks, within an individual brain.  Considering that social interactions play a major role in the acquisitions of skills and knowledge, I suggest a new approach for understanding interaction-based learning that focuses on inter-brain plasticity. The term coined here, inter-brain plasticity, will be defined as the short and long-term experience-dependent changes in brain-to-brain coupling. I argue that inter-brain plasticity in the observation-execution system develops over the course of interaction-based learning to facilitate information exchange between partners and thus learning. The proposed study aims at introducing a new theory on how inter-brain networks reorganize following training in interaction-based learning. It has three objectives: 1) To develop a model of inter-brain plasticity during learning (short-term), following training (long-term) and generalization between/within interaction partners; 2) To develop a novel dyadic-neurofeedback technology that allows drawing causal inferences between inter-brain plasticity and learning; 3) To test whether diminished inter-brain plasticity in Autism Spectrum Disorders may be reversed following training with the new dyadic neurofeedback. To address these questions, I will take advantage of the high temporal resolution of state-of-the-art dual-functional Near-Infrared Spectroscopy (fNIRS) setup and examine how intra- and inter-brain networks reconfigure during learning of various skills, ranging from motor learning to language acquisition. The proposed experiments will lay the foundation for a new field of research focusing on the dynamics of inter-brain networks. The inter-brain plasticity approach will ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advancing Binaural Cochlear Implant Technology' (ABCIT) targeting Seventh Framework.

assistant: **Abstract**

Cochlear implants (CI) are the most successful sensory prosthetic devices developed to date, as judged by their ability to restore sensory and motor function (i.e. hearing and normal speech patterns) in the profoundly deaf. With 1 in 7 of the population affected by hearing impairment, and an increasingly ageing population Europe-wide, sensory therapies for hearing are critical for the future physical, social and economic health of the European Union. Nevertheless, considerable progress remains to be made if CI users are to be able to hear and communication in even moderately challenging ‘cocktail party’ environments, where sources must be localized and individual conversations heard out from a background of multiple talkers, room reverberations and extraneous noise sources. This requires two-eared, or binaural, hearing. To this end, the next generation of cochlear implants will be binaural and feature semi-automated fitting procedures, aided by the objective measurement of evoked brain responses. The restoration of binaural hearing, the ability to integrate information from the two ears is critical to hearing performance. Although bilateral implantation (an independent implant in each ear) provides some opportunity for this, the temporal information required to achieve true binaural hearing is completely absent. The current proposal will develop the first generation of binaural implants capable of exploiting the temporal information arriving at each ear to provide true cocktail party listening for deaf individuals using cochlear implants, and a new generation of medical devices that take account of the requirements of the binaural brain to restore effective hearing. Significant benefit will accrue to the SME, Neurelec, in the development of new stimulation algorithms an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Filter to trap and retract emboli or foreign matters from blood' in the context of a Fifth Framework call.

assistant: **Objectives**

JOMED does research into a new generation of emboli filters based on a new concept leading to a safe and effective design, that :* does not significantly impede blood flow;* that reduces stress applied to the vessel wall;* that conforms to the vessel wall ;* that may be sized for use in a small vasculature ;* that may be used in a tortuous anatomy without increased delivery complications. JOMED is researching a novel concept for product design, more particularly, the area of research focuses on a resiliently self-expanding foam filter, which has the ability to capture and remove emboli, thrombus, and foreign bodies from a patient's vasculature. The foam filter should be attached to a (guide) wire, which facilitates the use in combination with a stent delivery system, or balloon catheter. The foam is suited for both conformably sealing against a vessel wall and for capturing emboli within one or more recesses. The foam can have a pore size that allows blood, but not dangerously sized emboli, to pass. The foam is elastomeric, allowing the filter to self-expand from a collapsed delivery configuration to an expanded deployed configuration. Use of foam permits the device to be contracted to very small diameters for delivery without a delivery catheter, or with delivery catheters having diameters as small as 3 F.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DiscardLess – Strategies for the gradual elimination of discards in European fisheries' under Horizon 2020.

assistant: **Concept**

The European Union has committed to the gradual elimination of discarding. DiscardLess will help provide the knowledge, tools and technologies as well as the involvement of the stakeholders to achieve this. These will be integrated into Discard Mitigation Strategies (DMS) proposing cost-effective solutions at all stages of the seafood supply chain. The first focus is on preventing the unwanted catches from ever being caught. This will promote changes in gear using existing and innovative selectivity technology, and changes in fishing tactics based on fishers’ and scientists’ knowledge.  The second focus is on making best use of the unavoidable unwanted catch. We will detail technical and marketing innovations from the deck, through the supply chain to the final market, including monitoring, traceability and valorization components. DiscardLess will evaluate the impacts of discarding on the marine environment, on the economy, and across the wider society. We will evaluate these impacts before, during and after the implementation of the landing obligation, allowing comparison between intentions and outcomes. Eliminating discards is as much a societal challenge as a fishery management one, so we will also evaluate stakeholders’ perception of discards. DiscardLess will describe the changes in management and the associated governance structures needed to cement the process. We will propose approaches to managing discards in a range of case study fisheries across Europe, encompassing differences in specific discarding issues. All these innovations will be combined in integrated Internet based interactive programs (DMS toolbox) that will help fishers to evaluate the present and future situation and to take a more qualified decision of how to adjust to the new regime.  Also, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhanced bi-regional STI cooperation between the EU and the Black Sea Region', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

BLACK SEA HORIZON has been designed to sustainably enhance bi-regional STI cooperation between the EU and the Black Sea region. The result of the project’s STI dialogue support will be an improved knowledge base about EU’s external environment and of the current framework for STI cooperation as well as an increased awareness to contribute to the elimination of remaining obstacles and to further intensify the bi-regional STI cooperation based on a jointly developed EU-Black Sea STI Cooperation Programme. To facilitate the pooling of resources the project will establish a group of committed funding parties, endowed with a functional call infrastructure and a clear set of rules and regulations, ready to implement a joint call for proposals. The participation of Black Sea researchers in HORIZON 2020 will be operationally facilitated through (i) identified common research topics taken-up in future calls for proposals, (ii) provision of up-to-date relevant information and good practices to participate in HORIZON 2020 to a large group of researchers, (iii) an increased number of joint research proposals through direct face-to-face meetings of, (iv) a young generation of social scientists trained in HORIZON 2020 and ready to promote and back up future RTI cooperation and (v) an increased readiness of programme owners both from the EU and Black Sea countries to engage jointly in JPIs and future COFUND ERA-NETs. Furthermore, the project will increase understanding of cluster policies and cluster management, establish direct business contacts between cluster managers from the EU and target countries and raise awareness on the programming of as well as on the advantages of inclusive, sustainable and social innovation. The project’s results will be broadly disseminated to increase a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Michelangelo network competitiveness and sustainability of nuclear energy in the European union'.

assistant: **Concept**

The objective of MICANET is to propose a strategy for the European R&D aimed at keeping the industrial nuclear option open in 21st Century. The approach will be global, including all aspects, from fuel cycle front end to final disposal, from technico-economic issues to political, social and psychologic dimensions of acceptance, connecting in a network projects that can contribute to MICANET objectives. Criteria of competitiveness and sustainability will be defined, to be satisfied for securing durability of nuclear energy. In front of new challenges, innovative approaches will be encouraged. Non-electricity applications of nuclear energy (e.g. hydrogen production, desalination) will be assessed. Existing means for R&D (expertise, test facilities) will be compared to needs and a policy for developing research centres of excellence in Europe will be proposed. Co-operation with similar foreign initiatives, in particular GENERATION IV, will be searched.The objective of MICANET is to elaborate a European R&D strategy corresponding to the actual needs of industry for facing more and more stringent challenges of competitiveness and sustainability. It will promote innovative approaches , maybe the only solution to face such challenges. MICANET approach will be global, including all aspects, from fuel cycle front end to final disposal , from technico-economic issues to political, social and psychologic dimensions of acceptance, proposing an appropriate balance of efforts between short, medium and long-term R&D, connecting in a network the various projects , which can contribute to MICANET objectives. It will lay the foundations of a long-term stable partnership between the main European organisations of nuclear industry and research, which will be the only way to support future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understanding Institutional Change: A Gender Perspective' (UIC) targeting Seventh Framework.

assistant: **Abstract**

What are the gender dynamics of institutional change?  Changing institutions is a fundamental part of the task of lessening gender inequality and yet the gender dynamics of institutional change are still poorly understood. Feminist scholars have long been interested in how to achieve the social, economic and political changes that will lessen inequality.  Huge changes in some women's social and economic status have occurred in many part of the world in the last fifty years.  Nonetheless multiple and intersecting unequal power relations as well as male domination remain commonplace in many institutional arenas – including judicial and political systems - despite measures such as quotas and equality legislation.  Improving our understanding of institutional change is therefore a key undertaking for feminist, if not all, social science as well as a public policy priority.  Crucially this institutional analysis will provide an important meso level link between the (sometimes unhelpful) overarching analyses of macro structures such as patriarchy and the more micro-level analysis of the actions and strategies of individual actors and groups that have often predominated.  Such an approach will allow scholars to develop better explanatory frameworks while at the same time maintaining historical and contextual specificity.  The programme will open new research agendas that systematically investigate how institutional change is gendered, why some forms of change appear more successful than others and how and why informal institutions operate in gendered ways.  The outcomes will be of use to both academics and practitioners who want to ensure that gender equity concerns can be more effectively embedded in institutions and processes of institutional design and reform.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Expressive Power of Tree Logics' under Seventh Framework.

assistant: **Concept**

Logics for expressing properties of labeled trees and forests figure importantly in several different areas of Computer Science, including verification (branching temporal logics) and database theory (many XML query languages). The goal of this project is to investigate the expressive power of tree logics, mainly those logics that can be captured by tree automata. A similar study, but for word languages, is one of the main lines of research in formal language theory. The study of the expressive power of word logics has lead to many beautiful and fundamental results, including Schutzenberger's characterization of star-free languages, and the Krohn-Rhodes decomposition theorem. We intend to extend this research for trees. The type of questions we want to answer is: what is the expressive power of first-order logic in trees? is there a Krohn-Rhodes decomposition theory for trees? what is a tree group? We expect that our study of tree logics will use algebraic techniques, possibly the setting of forest algebra (as introduced by the principal investigator and Igor Walukiewicz). We would also like to extend the algebraic setting beyond regular languages of finite trees, to e.g. infinite trees, or nonregular languages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'AID in adaptive immunity and beyond'.

assistant: **Objectives**

This proposal revolves around the enzyme Activation-Induced Deaminase (AID). AID plays a pivotal role in adaptive immunity because it is essential to introduce the lesions in the immunoglobulin genes that ultimately lead to somatic hypermutation (SHM), class switch recombination (CSR) and immunoglobulin gene conversion (Ig GC). However, its mutagenic ability has a pernicious side effect and AID has been implicated in B lymphomas and other neoplasias. Finally, because AID belongs to a family of cytidine deaminases including members with anti-retroviral properties due to their targeting of viral cDNA, cytidine deamination of DNA is yet another unforeseen link between innate and adaptive immunity. Here, I plan to use classical molecular approaches and genetically engineered mice to discover AID co-factors for CSR, to address the rules governing AID targeting to the immunoglobulin loci and to establish murine models to evaluate the impact of ectopic expression of AID. In addition, I describe how a functional assay I developed previously to characterize orthologous AID forms can be adapted to clone molecules from distant species able to introduce lesions in DNA, with the goal of better elucidating the evolution of somatic DNA modification.