RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scavidin: a fusion gene for the treatment of cancer' under Fifth Framework.

assistant: **Concept**

The main objective of the proposal is to develop a new target-specific delivery system for the treatment of malignant glioma. For that purpose we have cloned a new fusion gene Cave-in" which contains intracellular and membrane-spanning domains of scavenger receptor legated to avid in which will form the extra cellular domain of the fusion protein. Cave-in will be transfixed to target tissue with local gene therapy via catheter delivery or during surgical operation with adenovirus or pseudotyped retrovirus technology. Targeted treatment is achieved by binding of biotinylated compounds to Cave-in, which will be only expressed in the transfixed tissue."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NANOSCIENCE FOUNDRIES AND FINE ANALYSIS - EUROPE' (NFFA-Europe), addressing dissemination and exploitation.

assistant: **Impact**

NFFA-EUROPE will implement the first open-access research infrastructure as a platform supporting comprehensive projects for multidisciplinary research at the nanoscale extending form synthesis to nanocharacterization to theory and numerical simulation. The integration and the extension of scope of existing specialized infrastructures within an excellence network of knowledge and know-how will enable a large number of researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. The full suite of key infrastructures for nanoscience will become, through the NFFA-EUROPE project, accessible to a broader community extended to research actors operating at different levels of the value chain, including SMEs and applied research, that are currently missing the benefits of these enabling technologies.  NFFA-EUROPE sets out to offer an integrated, distributed infrastructure to perform comprehensive nanoscience and nanotechnology projects from synthesis and nanolithography (with nanofoundry installations) to advanced characterization and theoretical modellization/numerical simulation (with experimental installations including analytical large scale facilities and a distributed theoretical installation including high-performance computing).  Coordinated access will be given to complementary facilities co-located in nine well distributed main sites in Europe, ensuring the optimal match between user proposal and technical offer. The research activity of the Consortium will realize innovative solutions on key bottlenecks of nanoscience research, therefore upgrading the facility quality and uniqueness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Extensions of Temporal Representations for Ontology-based and Holistic Reasoning in the Mobile Quality of Life Domain' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The concept of Quality of Life (QoL) involves several dimensions, such as physical health and psychological state, which can be assessed by mobile resources and integrated to support holistic processes of reasoning and interventions. Ontologies are the main approach to organise and integrate such data in the form of knowledge. However, while temporal aspects are usually present in the health domain, modelling information evolving time/events in ontologies is a complex problem since temporal relations are ternary and cannot be directly handled by ontology languages. This lack of expressiveness restricts the power of the reasoning processes because several time aspects, which are usually embedded in the QoL domain, cannot be employed. This project aims to design a conceptual framework for representation and reasoning about temporal aspects, associated with an ontological engineering method to guide the use of this novel framework during the process of converting static ontologies to their temporal versions. This approach will be used over the development of four case studies: (1) general QoL ontology to represent the data acquired by the Quality of Life technologies lab over its longitudinal mobile assessments; (2) specialization of the QoL ontology for the aging population; (3) use of the previous ontologies as background knowledge to support the generation of explanations for inductive reasoning; and (4) use of the previous ontologies for QoL deduction-based interventions. The validation of these ontologies and their applications will consider technical (identification of inconsistencies and contradiction) and empirical (ability to provide answers for competency questions) methods. As the main expected result, this project intends to deliver a pragmatic strategy to supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A NEW UNIVERSAL MONITORING PLATFORM FOR INFRASTRUCTURES' (MORPHOSAVE) under Horizon 2020.

assistant: **Objectives**

MORPHOSENSE is a young start-up located in France and founded in 2016. MORPHOSENSE’s solution measures 3D deformation and 3-axes vibrations for any civil engineering structure, in continuous and real time. Implementation of the solution on each structure is extremely convenient. MORPHOSENSE represents the first solution for structure monitoring with a disruption based on technology (with a convenient measurement for deformations and vibrations in real time) and on service. Whereas other monitoring methods focus on measure instruments and not on data itself, MORPHOSENSE provides meaningful indicators and treated data that structure managers can exploit easily.The civil engineering sector needs such a solution to understand the behaviour of structures through time. 3D deformation and 3-axis vibrations measurements in real time allow such an understanding. Structure managers can thus have the “health record” of any structure.As the civil engineering structures park is ageing, it becomes critical to monitor structures that were built in the 50s to 70s. They are approaching their end-of-life. A real-time monitoring of their behaviour allows to know when reparations are needed, when costs are minimal.More generally, as MORPHOSENSE’s solution gathers data about structure behaviour, it opens up predictive maintenance in the civil engineering sector. Structures life-length will increase.The MORPHOSAVE project objectives are to industrialise and scale up our current prototype of measurement instrument, perform 6 pilot tests to bootstrap our market access in structures monitoring and maintenance. Our aim is to monitor several hundreds of structures by 2021 in the world. Moreover, a final objective will be to create with these pilot tests the first ever database for structures moni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cobalt and Lithium speciation, toxicity, and Bacterial community Regulations at the sediment-water-Interface' (CoLiBRI).

assistant: **Concept**

In the EU, transport is responsible for a quarter of greenhouse gas emissions. For the transition to a climate neutral economy, battery development and production strategies are thus important. By 2030, the EU expects an increased requirement of 18 times more lithium and 5 times more cobalt. These elements are released into the aquatic environment by mining processes and wastewater discharge. In aquatic systems, sediments are important and dynamic sinks or sources for such elements, depending on varying environmental conditions. The chemical state, bioavailability, and toxicity of these elements in aquatic systems is highly influenced by environmental parameters such as pH and temperature, which in turn are influenced by climate change. The goal is to investigate the toxicity of lithium and cobalt in aquatic systems under different environmental conditions. This will be addressed in 3 research objectives: 1) Investigation of the impact of temperature and pH on the distribution and chemical characteristics of lithium and cobalt within aquatic systems 2) Analysis of toxic effects of lithium and cobalt to zebrafish 3) Evaluation of lithium and cobalt related microbial community changes within the sediment. To address these objectives, we will perform a long-term exposure with zebrafish to selected sediments spiked with lithium and cobalt in an aquarium system capable of monitoring and regulating different water parameters. The toxicity will be determined with the zebrafish embryo toxicity test. Gene-expression analysis will reveal sub-lethal toxic effects of the selected elements. Bioaccumulation and content of lithium and cobalt in water and sediment will be quantified by ICP-MS. Changes in the sediment microbial community will be investigated by metagenome fingerprinting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ULtra ThIn MAgneto Thermal sEnsor-Ing' (ULTIMATE-I).

assistant: **Innovation**

Magnetic field sensing is a wide and important area of research and technological development in which every new magnetic or spintronic phenomenon discovered there would be an attempt to exploit it for magnetic sensing applications with improved cost-performances. Magnetoresistance is the ratio of the electrical resistance of a material with and without an applied magnetic field. This effect together with anisotropic magnetoresistance has led to a wide range of compact and high-sensitivity magnetic sensors for diverse areas of applications: Geophysics, Astronomics, Archeology, Health Care, and Data Storage. The basic physics of these effects are included in emergent field of Spintronic, field of knowledge that deals with the generation, propagation, processing and detection of spin currents. New effects appear with the spin currents as a central property like Spin Hall magnetoresistance (SMR) in hybrid materials ferromagnet/nonmagnetic metal; and other related phenomena: the Spin Hall Effect (SHE) and the Spin Seebeck Effect (SSE) where thermal sensing emerges. If we combine spintronic materials with multiferroic one’s new functionalities can be exploited where electric-field controls spin currents. These effects can be implemented in new strategies to design nanoscale devices. The development of both types of sensorsn thermal and magnetic sensors shares basic principles of spintronic, then we propose to work in ULTIMATE-I project with new hybrid combination of materials in which to better perform the spin to charge conversion, control of spin currents and producing sensor prototypes with outstanding performance. ULTIMATE-I project involves twelve partners with a strong background on spintronic, magnetic and multiferroic materials from EU and Third Countries, which will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Low Cost Interconnects with highly improved Contact Strength for SOC Applications'.

assistant: **Objectives**

Lower costs and a better long-term stability are needed to accelerate commercialization of Solid Oxide Cell (SOC) technology. Among the enduring challenges is degradation related to the steel interconnect (IC) material and insufficient robustness of the contact between the IC and the cell. LOWCOST-IC will tackle these issues by developing, fabricating and demonstrating low-cost ICs and exceptionally tough contact layers for use in SOC stacks. Novel robust contact layers, utilizing the concept of reactive oxidative bonding, will substantially improve the mechanical contact between the cell and the interconnect, while ensuring a low and stable area specific resistance. The cost of SOC ICs will be reduced by combining cost-effective high volume steel grades with highly protective coatings. Large-scale mass manufacturing methods will be demonstrated for application of the coating by physical vapour deposition (PVD), for subsequent shaping of the ICs by hydroforming and finally for fast printing of contact layers by a drop-on-demand process. Novel computationally efficient stack models will together with hydroforming be customized to decrease the prototyping costs and thereby accelerate IC development.The new interconnect steels, coatings and contact layers will be implemented in the SOC stacks of two commercial manufacturers and undergo extensive testing in an industrially relevant environment. Finally, the cost-effectiveness of the proposed production route will be assessed and compared with existing production routes to facilitate a fast market entry of the project innovations. The overall effort will bring the technological solutions from their current TRL 3 to TRL 5. To achieve the optimum output, the LOWCOST-IC consortium comprises the entire interconnect and contact l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mobility Programme of Slovak Academy of Sciences: Supportive Fund for Excellent Scientists' (SASPRO).

assistant: **Innovation**

In the proposed project, Slovak Academy of Sciences (SAS) intends to build up mobility programme for foreign researchers allowing them to work at SAS scientific organisations. The main objectives are to increase quality of Slovak science and research by increasing excellence of SAS institutes as well as create optimal conditions for fellows to perform their research and boost their career.Fellows will freely choose from a wide spectrum of SAS research institutes covering technical and natural sciences, life sciences as well as humanities and social sciences. SAS institutes are located in all Slovakian regions.Top foreign scientists will be selected for fellowships; fellows will enrich research teams and SAS and will contribute to raising the quality level of Slovak and European science and research. On the other hand, SAS will provide all tools for their career and personal development and ensure broadening and deepening of their scientific and non-scientific experience and skills.The results of the programme realization will be establishing a quality international cooperation network, strengthening the European science and research position in the world and reducing its fragmentation in several areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Rare Earth Free e-Drives featuring low cost manufacturing'.

assistant: **Innovation**

The ReFreeDrive project is focused on contributing to avoid the use of rare earth magnets through the development of a next generation of electric drivetrains, ensuring the industrial feasibility for mass production while focusing on the low cost of the manufacturing technologies. This proposal intends to study and develop simultaneously two solutions for the power traction system of electrical vehicles. Both solutions are brushless AC electrical machines: induction machine with fabricated and copper die-cast rotor (IM) and synchronous reluctance (SynRel) machine. Through their configurations these machines not only are rare-earth magnet free, but also share common features that can be exploited during the design step, as well in the manufacturing process. These common features lead to a complex synergy between the two technologies, which justify the development of different topologies of electric machines in just one project.The design of the ReFreeDrive motors will take as a premise the reduction of use of materials, as more than half of the final price is formed by raw materials cost. Also, a minimization of manufacturing costs will be ensured by an early involvement of manufacturers, from the design stage. ReFreeDrive motor topologies have good room for cost reduction by off-setting permanent magnet use. However, it is not feasible to change the commodity prices for copper and steel. Therefore, one of the key avenues for cost reduction is the reduction of size through different techniques (outer rotor, higher rotational speed, compact winding…). An optimized use of copper on the project provides technical design with a higher efficiency due to lower losses regards other alternatives, and more efficient heat management.Beyond the motor design, ReFreeDrive also consid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of oleic acid in the development and neuroprotection of the Central Nervous System' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Our previous work has shown that oleic acid is a neurotrophic factor that promotes neural differentiation. In fact, oleic acid is taken up by neurons in which induce neuronal differentiation by promoting axonal growth, neuronal clustering and the expression of GAP-43 and MAP-3, markers of axonal or dendritic development, respectively.Moreover, during the postnatal period the increase in the concentrations of free oleic acid in the brain comes along with the expression of GAP-43 and MAP-2 concurring with postnatal 'secondary neurogenesis', a phenomenon observed in ¿non precocious species¿ such as human. In this work, we try to get inside the cellular and molecular mechanisms by which oleic acid promotes neuronal differentiation in order to understand the role played by oleic acid in brain development.This study can help to modulate the nutritional status of the newborns in order to enhance their intellectual development. In addition, our results can help also to understand a possible neuroprotector role of oleic acid against brain degeneration. If so, oleic acid may be used in the treatment of degenerative diseases such as Alzheimer or Parkinson.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hematopoietc Stem Cells emergence in the mouse embryo: function(s) of RUNX1 and its binding partner CBFbeta', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Newly formed mature hematopoietic cells are generated through a complex maturation process based on the differentiation of Hematopoietic Stem Cells (HSC). In the mouse embryo, HSCs are first detected in the Aorta-Gonade-Mesonephros (AGM) region at midgestation.They arise from the major arteries and are thought to differentiate from a population of hemogenic endothelial cells (EC). Cellular events that occur during AGM-associated hematopoiesis are well-documented, but the underlying molecular mechanisms are still under investigation. The overall objective of the present project is to further our understanding of molecular regulations governing early production of HSCs from hemogenic ECs.It is focused on the RUNX1 transcription factor, a key regulator of HSC production and a frequent target in human haematological malignancies. In mouse embryo, disruption of either Runx1 or its co-factor Cbfb leads to complete failure in HSC development. RUNX1 is known to govern this process at the level of hemogenic ECs and to mark all HSCs at midgestation.However, since the requirement of CBFb in this process is poorly understood and the accurate function of RUNX1 is not known, the specific aims of this project are:1) To describe the expression of the RUNX1 binding partner, CBFb, in midgestation aortic HSCs and ECs2) To conditionally knockout Runx1 during different stages of the EC to HSC transition in the midgestation aorta.For this purpose, transgenic mouse models will be generated and AGM-associated hematopoiesis will be analysed using a large panel of descriptive and functional approaches. Innovative methodologies will be undertaken to analyse the complex biological activity of RUNX1.We will use fluorescent markers to follow genes expression and cell fate and also design a Cre-loxP