RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hand to Mouth: A framework for understanding the archaeological and fossil records of human cognitive evolution', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

HANDTOMOUTH develops a framework for understanding archaeological and fossil evidence for the evolution of speech and manual dexterity. We focus on low-order parameters which can potentially be assessed in fossil and archaeological evidence. The focus will be on motor control in complex, serially ordered, goal-directed movements, with two sub-themes: Speech production. This will include physical and digital modelling of vocal tracts of extinct hominins based on anatomical parameters, to recover the range of articulatory manoeuvres and acoustic characteristics. There will also be a comparative anatomical study of primate cranial nerves, which will address a neural substrate for speech motor control and sensory feedback regulation. The modelling will include small-scale perturbations of the model system to determine which components of the vocal tract are most sensitive in terms of effects on sound characteristics, and this will enable prediction of which cranial nerves may have increased sensory fibres as a speech-related adaptation. Tool use. This will address the relationship between action understanding and the self-generation of action sequences in human and non-human primates. It will include activation analysis of cortical motor circuits in the action system of nonhuman primates in sequentially complex action observation tasks, and kinematic analysis movement control in stone tool-making and other tool-using tasks in healthy and apraxic human subjects. As a unifying framework, we intend to re-evaluate the possibility that tool use may have co-evolved with speech, reflecting shared features of neural architecture. We identify possible areas of convergence and/or homology in behavioural organization and in neural architecture in the two systems. HANDTOMOUTH will enab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single-Molecule studies of photo-conductance on photosynthetic molecular systems by SPM break-junction measurements' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This proposal presents a new fundamental approach to study one of the most outstanding processes in nature at the single-molecule level; the photo-induced charge separation process on molecular photosynthetic systems. The last technical advances, especially on Scanning Probe Microscopies (SPM), have allowed approaching a number of relevant molecular processes to a single-molecule level, fact that has brought a revolutionary view to the field of Molecular Biology and a more quantitative comprehension of fundamental bio-molecular processes. Indeed, examples of single-molecule experiments like folding/unfolding of proteins, DNA-enzymes interactions or molecular conductance measurements have become today a reality. In the last, electrical conductance measurements through a variety of simple molecular architectures have been already performed, and relevant fundamental roles such as the presence of different chemical entities; double bounds and/or chemical electron-acceptors/donors in the conduction mechanism, have been already understood. Being immersed in such an excitingmolecu scenario, we have now the opportunity to go one step further and tackle into the analysis of more complex molecular conductance processes at the single-molecule level. Conductance taking place between specific molecular centers at the primary electron transfer step in Photosynthesis is undoubtedly the most important molecular conductance mechanism in life. We have now all required elements at hand to put such a project in practice; technical instrumentation to measure single-molecule conductance under physiological conditions as well as synthetic routes to design the mimetic molecular connections among the photo-conducting pigment and the corresponding secondary electron-acceptor cofactor to approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomimetic surface modification of tissue engineering scaffolds with glycosaminoglycans' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The replacement of bone and cartilage by tissue engineering is still hampered by the lack of degradable biomaterials that stimulate the growth and differentiation of cells. The layer-by-layer (LbL) technique has been identified as a useful tool to immobili se biogenic ligands maintaining their biological activity. It is an environmental safe, simple and cost efficient method to create material surfaces that are organised at the nanometer scale. LbL technique has been applied recently to coat the surface of biomedical materials using simple combinations of synthetic polyions and certain biological molecules. It is the aim of the project to apply the LbL technique for the biomimetic surface modification of polylactid acid (PLA) as a material approved for biome dical applications. The coating shall resemble main components the structure of the extracellular matrix (ECM) by using collagens and different glycosaminoglycans (GAG). The signalling capabilities of the ECM shall be mimicked by incorporation of adhesive proteins, such as fibronectin and growth factors. The binding of these molecules shall be achieved by their inclusion during the LbL process as well as their biospecific adsorption to the outermost layer of GAGs. The structure and properties of the LbL coa ting will be investigated by physicochemical methods. The biological activity will be studied with cultures of mesenchymal stem cells looking at cell growth and differentiation. Hence, the scientific focus of the project is on nanobiotechnologies and nanom etre scale engineering techniques which is a subtopic of the NMP priority. The project is also aimed to help the fellow to become an independent and experienced researcher by a number of training activities. This involves the participation in courses, the coope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'In-situ thermal rock properties lab' (ITHERLAB).

assistant: **Concept**

The ITHERLAB project investigates the influence of in-situ (present state in the geological subsurface) pressure and temperature on rock thermal properties (thermal conductivity and thermal diffusivity) as one of the essential thermal properties in the evaluation of the Earth thermal field. The ITHERLAB project will establish mathematic formulations for p/T dependence of both parameters and demonstrate whether micro-structural effects affect these relations for different rock types. For that purpose, an innovative laboratory device will be developed and pilot-tested allowing for dry and saturated rocks measurements of thermal conductivity and thermal diffusivity at pressures and temperatures that are simultaneously raised to values up to 200 MPa and 200°C, respectively. These are the conditions for depths (to approx. 7 km), which are of interest in the use of Earth resources (such as geothermal energy, hydro-carbons, storage of energy or waste). Currently, no laboratory standard procedure exists for this task. Precise knowledge of reliable in-situ thermal rock properties and derived thermal parameters (e.g. heat-flow density) is in-dispensable for understanding the Earth’s subsurface thermal structure and heat budget. Heat mainly drives geody-namic processes (e.g. mantle convection, plate tectonics). Practical implications for the society are arising for exam-ple from the extraction of the Earth’s heat for heating purposes or electricity generation and from the subsurface storage of heat to compensate different seasonal energy demands - techniques that can help to secure and diversify Europe’s energy supply. Moreover, knowledge and methods provided by the ITHERLAB project are paramount for the planning, management and realization of any scientific and industrial subsurf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Synergies and Co-operation for Sustainable vehicle along the Life-Cycle' under Seventh Framework.

assistant: **Concept**

The whole transport industry has to tackle major world-wide challenges such as combating climate change, sustainable use and management of natural resources and waste, energy saving, reducing CO2 emissions, etc.In this context, Europe has adopted ambitious goals towards 50% more efficient road transport system by 2030 decoupling economical growth with transport development needs, overcoming energy and economic crisis, accelerating catch up with the US and keeping ahead of rapidly developing Asian countries.The technological development of specific parts of the value chain is recognized as potential sources for technological progress with significant economic growth. However, since advanced technologies of each component of the transport-related industry are often based on certain stand-alone paths (e.g. addressing only recycling of old vehicles, or only design and construction of new-ones, not looking at the entire value chain) is challenged by several hurtles, it is critical to develop a more holistic and integrated approach of the entire value chain of this industry.Indeed, only such an approach will enable the whole sector to move up a gear in greening its entire life cycle from conception and construction, via use, end-of-life and deconstruction to waste valorisation.To this end, the S_LIFE project aims at a developing the cooperation between EU world-wide class clusters in order to help them develop new scientific (multi-disciplinary research environment), economic (new business model covering entire value chain) and structural (RTD and new technologies-oriented) coherent greening solutions all along the value chain.S_LIFE project will develop strategies and a Joint action plan to link, mobilize and coordinate regional resources with more focus on this challenge. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Working Environment with Social and Personal Open Tools for inquiry based learning', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

weSPOT aims at propagating scientific inquiry as the approach for science learning and teaching in combination with today's curricula and teaching practices. It lowers the threshold for linking everyday life with science teaching in schools by technology. weSPOT supports the meaningful contextualization of scientific concepts by relating them to personal curiosity, experiences, and reasoning. weSPOT addresses several challenges in the area of science learning and technology support for building personal conceptual knowledge. The project focuses on inquiry-based learning with a theoretically sound and technology supported personal inquiry approach. In inquiry based-learning learners take the role of an explorer and scientist and are motivated by their personal curiosity, guided by self-reflection, and develop knowledge personal and collaborative sense-making and reasoning. weSPOT will work on a meta-inquiry level in that it will (a) define a reference model for inquiry-based learning skills, (b) create a diagnostic instrument for measuring inquiry skills, and (c) implement a working environment that allows the easy linking of inquiry activities with school curricula and legacy systems. The foreseen weSPOT Toolkit gives smart support for personal scientific inquiry to address a lack of scientific inquiry skills in an age group of 12-25. Furthermore, weSPOT will unleash support of triggering and leveraging curiosity that is missing in today's learning technology. weSPOT will develop (1) an open source service framework for inquiry workflows, (2) tools for mobile data collection and personal experience sampling. Additionally, it will develop (3) learning analytics tools for collaborative and personal reflection, and (4) a badge system for linking formal and informal learnin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bioactive Marine Natural Products in the Field of Antitumoral, Antiviral and Immunomodulant Activity' to be submitted under Fourth Framework.

assistant: **Abstract**

The purpose of this project is to interest the European pharmaceutical industry in new molecules of marine origin relating to three complementary fields: antitumoral, antiviral (AIDS, herpes, dengue) and immunomodulatory substances. The project is based on the great originality of substances present in marine organisms, mainly invertebrates. Moreover, a considerable number of species have not yet been studied for their pharmacologic aspects. The success of this project depends mainly on the capacity of the participating teams to carry it out effectively (Cf. the presentation letter attached to the application) and the scientific options taken: 1. Two branches have been retained for study: sponges and tunicates (ascidians). Sponges have provided the largest number of original marine molecules, including several of pharmacologic interest. The ascidians, composed of fewer species, were chosen because of the exceptional frequency of nitrogenous metabolites which often possess high activity. Moreover, both of these branches consist of filtering organisms, and it has often been suggested that several pharmacologically important metabolites come from their associated microorganisms. This is a considerable advantage in the perspective of biotechnological production of interesting molecules. We have selected a variety of sampling areas: two widely separated tropical zones (the Vanuatu and the west coast of Madagascar), for which we have noted an important, original biological potential; a warm temperate zone (the Mediterranean), where sponge collection at Ustica Island has provided several interesting leads which will be followed up in the project; and a cold temperate zone (the Atlantic coast of France) which is still unexplored with respect to potentially antiviral and immunom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Foundations for Antitrust and Policy on Digital Platforms' (FAPoD).

assistant: **Concept**

Internet markets tend to concentrate in the hands of a very few large platforms. These platforms have been accused of abusing their monopoly power vis-a-vis their users (consumers, sellers, advertisers) and maintaining the latter through hostile behavior towards potential competitors. They are said to harm users by ‘self-preferencing’, data harvesting, creating 'monopoly positions' and extracting resulting rents with high fees, all the while avoiding competition by acquiring, copying and otherwise disadvantaging potential competitors. This proposal addresses these concerns in four parts. Part 1 focuses on the dual role of online marketplaces, whereby the platform both runs the marketplace and acts as a seller on it. I aim to understand how such hybrid marketplaces conduct themselves toward consumers and third party sellers. The model will be used to evaluate recent policy proposals and suggest ways to avoid significant unintended consequences.   Part 2 studies how platforms steer consumers to sellers. As most platforms let sellers set prices and collect fees on revenues, a platform’s own algorithm and her choice to augment/replace it with a position auction may be consequently driven by revenue maximization. I plan to show that steering systems may drastically alter pricing, leading to ‘mediated’ competition.  Part 3 explores the nature of recommendation algorithms, particularly the interplay between consumer search and algorithm effectiveness. I demonstrate that algorithms may be self-fulfilling and self-defeating, which determines their effectiveness and significantly alters the resulting allocations and their efficiency.   Part 4 explains the circumstances in which an incumbent platform may acquire an upstart platform. These depend on,  the overlap of existing user b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Data Driven Game Theoretic Control for Constrained Systems' (ARGON).

assistant: **Innovation**

The European society relies heavily on large-scale infrastructures, e.g. power and gas grids, transportation networks, with interconnected and self-interested sub-systems, e.g. networked control units, semi-autonomous robots, intelligent machines and humans. Due to high complexity, variability and uncertainty of their real-life operations, accurate dynamic, behavioral and interference models are hardly available. Nevertheless, the deployed control systems are either simplistic regulators or advanced controllers based on unreliable models. Model-based game theory and distributed optimization have attracted extraordinary research attention but in real-life practice are ineffective for control design due to the unavailability of reliable models and the limited information exchange between sub-systems. Data-driven optimal control has emerged as a practical control approach to mitigate model awareness, but only for cooperative systems. A paradigm shift is thus necessary to ensure safe, fair and efficient operation in systems with self-interested sub-systems. With this aim, ARGON will initiate the whole new area of data-driven dynamic game theory for constrained systems and in this scientific context it will pursue the twofold objective to: (i) conceive a general data-driven game-theoretic control framework; (ii) provide fast and scalable computational methods for solving data-driven decision and control problems. Towards these objectives, ARGON will develop novel methodologies based on distributionally robust operator theory and feedback control for equilibrium seeking, and integrate new ideas across monotone game theory, Lyapunov stability theory for constrained systems, data-driven control of switched systems. The expected outcomes are a mathematical theory and computation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Systematic Models for Biological Systems Engineering Training Network' (SyMBioSys) targeting Horizon 2020.

assistant: **Abstract**

Mathematical, computational models are central in biomedical and biological systems engineering; models enable (i) mechanistically justifying experimental results via current knowledge and (ii) generating new testable hypotheses or novel intervention methods. SyMBioSys is a joint academic/industrial training initiative supporting the convergence of engineering, biological and computational sciences. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early-stage researchers (ESRs) to develop and exploit cutting-edge dynamic (kinetic) mathematical models for biomedical and biotechnological applications. SyMBioSys integrates: (i) six academic beneficiaries with a strong record in biomedical and biological systems engineering research, these include four universities and two research centres; (ii) four industrial beneficiaries including key players in developing simulation software for process systems engineering, metabolic engineering and industrial biotechnology; (iii) three partner organisations from pharmaceutical, biotechnological and entrepreneurial sectors. SyMBioSys is committed to supporting the establishment of a Biological Systems Engineering research community by stimulating programme coordination via joint activities. The main objectives of this initiative are: * Developing new algorithms and methods for reverse engineering and identifying dynamic models of biosystems and bioprocesses* Developing new model-based optimization algorithms for exploiting dynamic models of biological systems (e.g. predicting behavior in biological networks, identifying design principles and selecting optimal treatment intervention) * Developing software tools, implementing the preceding novel algorithms, using state-of-the-art software engi