RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A completely biological and human tissue-engineered sling produced from Cell-Assembled extracellular Matrix (CAM) in vitro for the treatment of Stress Urinary Incontinence (SUI)' (CAM) under Horizon Europe.

assistant: **Objectives**

Stress Urinary Incontinence (SUI) is a major medical issue affecting 1 in 5 women. Implantation of synthetic slings, made of knitted plastic monofilament, is the gold standard surgical treatment. They provide mechanical support to the urethra avoiding involuntary loss of urine on effort. However, they are associated with serious complications and some countries have already suspended their use. Hence, there is a strong medical and societal need for breakthrough innovations. The two fundamental problems of synthetic slings are the excessive hardness of the material and the foreign body reaction it creates. We propose a new paradigm by providing a non-living tissue-engineered sling that is soft, yet strong, as well as completely biological and human. Our strategy is based on a unique material: the Cell-Assembled extracellular Matrix (CAM) produced by fibroblasts in vitro. We can produce robust CAM sheets from human or ovine cells with similar properties.  They are cut to produce threads subsequently woven into CAM slings.The potential of CAM slings to treat SUI will be demonstrated through 2 main tasks:1) Development of human and ovine CAM slings with mechanical properties justifying a preclinical study.2) In vivo validation of allogenic CAM slings in a female sheep model at 2 and 6 months.This PoC will:1) Prove that human CAM slings can have clinically relevant mechanical properties;2) Demonstrate that equivalent ovine CAM slings can be successfully implanted in a clinically relevant, allogenic, large animal model;3) Show a superior integration of ovine CAM slings compared to synthetic slings (reduced immune response and positive remodeling).Overall, this PoC will increase the technology readiness level of our product from 1-2 to 3-4. These outcomes will justify an expan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Big Data Value Spaces for COmpetitiveness of European COnnected Smart FacTories 4.0' (2014-2020).

assistant: **Innovation**

EFFRA recommendations on Factories 4.0 and Beyond (Sept 2016) clearly stated the need for development of large scale experimentation and demonstration of data-driven “connected smart” Factories 4.0, to retain European manufacturing competitiveness. BOOST 4.0 will address this need, by demonstrating in a measurable and replicable way, an open standardised and transformative shared data-driven Factory 4.0 model through 10 lighthouse factories. BOOST 4.0 will also demonstrate how European industry can build unique strategies and competitive advantages through big data across all phases of product and process lifecycle (engineering, planning, operation, production and after-market services) building upon the connected smart Factory 4.0 model to meet the Industry 4.0 challenges (lot size one distributed manufacturing, operation of zero defect processes & products, zero break down sustainable operations, agile customer-driven manufacturing value network management and human centred manufacturing). Our chief objectives include: (1) Establish 10 big data lighthouse smart connected factories (VW, FILL, AutoEuropa, +GF+, FIAT, Phillips, Volvo, GESTAMP, Benteler, Whirlpool). (2) Provide the RAMI 4.0 and IDS based BOOST 4.0 open EU framework and governance model, for both services and data assets. (3) Put together methodologies, assets, models and communities in order to maximise visibility, mobilization, replication potential, and impact (business, financial, standardization) of BOOST 4.0The investment leveraging factor of BOOST 4.0 will be well above the 4:1 ratio, up to 10:1. In terms of exploitation, in 5-years horizon after the project end, just only the participating lighthouse factories will make a direct follow-on investment above 33Meuro (ROI 10,61), while the commercialis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Harnessing the immense potential of precision fermentation to produce animal fats for the next generation of meat and dairy alternatives' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Melt&Marble (M&M) is a Sweden-based company that specializes in developing exceptional fats for plant-based foods. The origins of our company trace back to Jens Nielsen's Systems and Synthetic Biology group at Chalmers University of Technology in Gothenburg, Sweden. Currently, more than 60% of dietary proteins are supplied by animals whose farming takes up ~77% of all agricultural land despite supplying only 17% of the world’s calories. Dependence on animal proteins leads to ecosystem destruction, biodiversity loss, and >15% of GHG emissions. Though there are alternate meat and dairy options available, the plant-based oils and fats used in plant-based meat and dairy analogues simply cannot compete with the functionality and flavour of animal fats. We have created for the first time, a scalable, precision-fermentation-based proprietary technology platform using engineered yeasts that produce animal-like fats with superior functionality and flavour that customers are demanding. The fats have lower saturated fats levels (40-60% vs. 90% of coconut oil) and better functionality than coconut oil to impart a better taste to meat and dairy analogues. The entire technology platform is scalable due to the existing and outsourced fermentation infrastructure.The fats are customizable to various food and non-food applications and will benefit the alternative meat producers within the EU and globally. Our technology is protected by a robust IP strategy and patents. We have 10 granted patents and 2 pending patents across 5 patent families and the innovation stems from 2 crucial components protected by these IPs that allow us to efficiently produce highly tailored fats.We have already scaled up our first product to pilot scale (TRL 5). Within this project, we will improve our productio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Tyre and Road Interaction (ITARI)' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Future trends indicate that passenger road traffic will increase by 20% from 1998 to 2010. Goods transport by road is predicted to increase by almost 40% during this period. To assure that road transport can be considered as sustainable, it is necessary to reduce the negative consequences of road traffic to an acceptable level. Road traffic with its conventional heat-engine vehicles is one of the main sources of urban pollution from greenhouse gases. It also contributes to the European Union's excessive energy consumption. With increasing efficiency of engines, secondary effects such as rolling resistance, now play a dominant role when aiming for further reduction of fuel consumption. Road traffic noise is a major environmental problem. At the CALM workshop a reduction of 19 dB were suggested as short-term target for the year 2010. A major component of road traffic noise is now tyre/road noise. Therefore to achieve the proposed reduction targets it is necessary to reduce tyre/road noise, which is still in the domain of research rather than existing knowledge. Safety is the crucial demand on road surfaces, so design of new low noise textures or textures with low rolling resistance must not risk the grip potential (especially under wet conditions). Currently more than 40,000 persons are killed on EU roads every year, but the strategic objective is to cut this number by 50% within the next eight years and 75% by 2025. The objective of ITARI is to provide the necessary tools to investigate new road surfaces with lower noise emission and lower fuel consumption and at the same time meeting safety requirements. In addition to this ITARI will demonstrate the implementation of virtually prototyped road surfaces in the production process of road surfaces. ITARI will supply knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Enhanced Energy Production of Heat and Electricity by a combined Solar Thermionic-Thermoelectric Unit System'.

assistant: **Innovation**

Concentrating solar systems are matter of relevant and constantly increasing interest of the energy market owing to the compact size, reduced request for components, capability to be multi-generative, potential high-efficiency and low-cost.This project aims to design and realize innovative and scalable components for solar concentrating systems that generate both electricity and heat and work efficiently at high temperatures (800-1000°C).The proposed concept includes the design, realization and testing of several new component technologies. A high-temperature receiver will be developed to provide the heat input to the converter unit. A new-concept conversion module will be developed for electrical and thermal energy production based on thermionic and thermoelectric direct converters, thermally combined in series to increase the efficiency (thermal-to-electrical efficiency estimated to 35%). A heat recovery system will be designed to collect waste heat (standard efficiency of 65%) and provide it as an additional energy product (co-generation). Innovative wirings for fluid and electricity transport will be designed, realized and tested. The benefit associated to a single hybrid cable, able to carry both relatively high-temperature fluids and electricity, will be characterized and demonstrated.A small-scale prototype solar system will be realized to test and evaluate the real impact of the new components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New and renewable energies, electricity and water in outermost regions (ERA_ISLA)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The present action will explore the 6th FWP instruments as means to boost integration of new and renewable energies for electricity and water production as a contribution to EU outermost regions and similar third countries regions sustainable development. The action will analyse three 6th FWP instruments: Article 169, networks of excellence and integrated projects, and will create an appropriate framework to implement Articles 169 and 299 (2) of the Amsterdam Treaty. This overall objective will be achieved by identifying functional links between the institutions and programmes, at local (outermost region), national (Member States and Candidate Countries) and community (EU) levels, to provide a specific co-operative implementation structure at these levels. The action will also identify possible integrated projects to address energy and water problems in EU outermost regions and will create the basis for a Network of Excellence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Patient Empowerment through Predictive PERsonalised decision support' in the context of a Horizon 2020 call.

assistant: **Objectives**

This proposal is for a personalised decision support system for chronic disease management that will make predictions based on real-time data in order to empower individuals to participate in the self-management of their disease. The design will involve users at every stage to ensure that the system meets patient needs and raises clinical outcomes by preventing adverse episodes and improving lifestyle, monitoring and quality of life. Research will be conducted into the development of an innovative adaptive decision support system based on case-based reasoning combined with predictive computer modelling. The tool will offer bespoke advice for self-management by integrating personal health systems with broad and various sources of physiological, lifestyle, environmental and social data. The research will also examine the extent to which human behavioural factors and usability issues have previously hindered the wider adoption of personal guidance systems for chronic disease self-management. It will be developed and validated initially for people with diabetes on basal-bolus insulin therapy, but the underlying approach can be adapted to other chronic diseases. There will be a strong emphasis on safety, with glucose predictions, dose advice, alarms, limits and uncertainties communicated clearly to raise individual awareness of the risk of adverse events such as hypoglycaemia or hyperglycaemia. The outputs of this research will be validated in an ambulatory setting and a key aspect will be innovation management. All components will adhere to medical device standards in order to meet regulatory requirements and ensure interoperability, both with existing personal health systems and commercial products. The resulting architecture will improve interactions with healthcare profe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BIOphilic MetroPOLIS, a holistic model for urban planning and building climate resilience' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the Anthropocene climate change is the greatest threat to socio-economical prosperity, environmental and human health as well as a priority in the European and Global Agenda. In an increasing and unbalanced urban planet, metropolises play a key role in addressing climate challenge but this requires a significant paradigm shift in urban planning. Nature contributes to urban climate and improves the quality of life. The growing attention to biophilic design confirms this power. BIO-POLIS aims to promote biophilic metropolis as a holistic urban model able to enhance livability restoring the man-nature relationship and to drive decision-makers in placing nature at the core of planning as the most ecological strategy to build climate resilience. The research is designed as a comparative study among overpopulated zonobiomes. Through an integrated, interdisciplinary and cross-scale method, it will advance the framework on Biophilic Urbanism, map the natural capital by digitalisation, explore biophilic features and processes, assess the biophilic potential in building climate resilience, provide an atlas of biophilic mitigation and adaption nature-based solutions in different biomes. The proposal will have multiple impacts. The biophilic guiding model aspires to turn the functional approach of city planning into a scientific one based on the human-nature interaction. Project results will influence citizens increasing public awareness of urban nature and inspiring biophilic lifestyle. Comparing various geo-contexts will encourage international cooperation among cities and partner institutions towards global and local strategies and boost the European role in R&I for sustainable development and climate change. The excellence of partners will offer me the best training and rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Construction of protein linkage maps btween yeast saccharomyces cerevisiae nuclear proteins involved in RNA processing' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The main aims of the project are: 1) to identify novel yeast proteins that are involved directly or indirectly in the mechanisms or regulation of various aspects of the production and processing of nuclear RNA, including transcription, 5' capping, splicing, 3' end processing/ polyadenylation and transport between the nucleus and the cytoplasm through the nucleopore, 2) to determine patterns of interaction between previously characterised and newly identified proteins, 3) to use these data to assign tentative functions to the newly identified ORFs, 4) to detect and investigate functional links between different pathways of RNA metabolism, for example between transcription and splicing, or between splicing and export, 5) to detect links between these pathways and other cellular processes, for example between the cell cycle and splicing or transcription, and to identify the factors making the connection(s), 6) to improve and optimise the technology of the existing two-hybrid method, 7) to evaluate the efficacy of the two-hybrid approach for obtaining these kinds of data, 8) to develop a novel twohybrid method based on activation of RNA polymerase III that will permit this approach to be extended to the analysis of polymerase II transcriptlon factors, 9) to produce computer programs that will facilitate the collection and analysis of sequence data from the fusion proteins, and 10) to assess the feasibility of extending this protein linkage analysis to other systems, either to other biochemical pathways in yeast or to higher eukaryotes. The ultimate aim is to produce a detailed linkage map representing physical interactions between proteins that are functionally related, having roles in the mechanisms or regulation of pathways involved in RNA metabolism. The partners in this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Digital Single Cell Immunology: Decoding Cellular Interactions for Improved Immunotherapy' (ImmunoCode) under Horizon 2020.

assistant: **Objectives**

Successful immunotherapy against cancer is the result of a multitude of cellular interactions within the immune system. It is highly exciting how vaccination with small numbers of human plasmacytoid dendritic cells (pDCs) can induce anti-tumour immunity in metastatic cancer patients. Remarkably, how pDCs, as an extremely rare subset of cells, can act as Swiss army knives to regulate the tight balance between tolerance and immunity: i.e. secrete massive amounts of type I IFNs, prime T cells and exert cytotoxic effector functions, is still elusive. Do pDCs possess all functions or comprises the population distinct functional subsets all with their specialized roles. I will unravel which pDC is superior in inducing cytotoxic T cells (CTLs) for augmented cancer immunity. Despite advances in single cell technologies, understanding the role of heterogeneity in immune cell populations, remains poorly understood. In ImmunoCode, I will develop a novel and ambitious single cell technology platform, wherein innovative microfluidic approaches and single cell transcriptomics allow 1) functional analysis of single (pairs of) immune cells and 2) design of minimal environments under the omission of external factors that could influence cellular behaviour. This approach will provide me with the unique opportunity to unravel pDC function and plasticity. Although in this ERC proposal I will focus on understanding pDCs heterogeneity, my technology can in fact be exploited to any cell type that shows heterogeneous function. My unique and high-risk technical approach allows for decoding immune cell-cell or cell-pathogen interactions longitudinally and in great detail which will revolutionise the fields of immunology and cellular immunotherapy. Ultimately, ImmunoCode will have a tremendous im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New Tools for Innovation Monitoring (NETIM)'.

assistant: **Innovation**

The “New Tools for Innovation Monitoring” (NETIM) project aims to capitalize on the experiences carried out by Innovation Agencies around the world concerning the most effective and simple methods for collecting, elaborating and rendering data related to the implementation processes of innovation policies and measures. For this purpose, a Twinning Advanced mechanism will be set up among the three partner agencies in order to allow them to jointly evaluate existing approaches to policy monitoring (both developed by the partners themselves and from other agencies and bodies worldwide), select the most convincing solutions and design/adapt a new monitoring tool. The selection process will be guided by a pragmatic approach, with the goal of individuating those solutions to policy monitoring that have been proven to be simple, effective and cost-efficient.  On this base, a new monitoring tool will be assembled, by designing:•a suitable list of indicators •an interpretation grid for the selected indicators•an efficient data collection system•a multi-level data analysis and reporting tool (for policy makers, for beneficiaries, for larger audience).The final project output will be a Design Options Paper that will guide other agencies and bodies to the practical implementation of the NETIM monitoring tool in their regional context.