RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BiogENesis and Degradation of Endoplasmic Reticulum proteins' under Horizon 2020.

assistant: **Concept**

The Endoplasmic Reticulum (ER) membrane in all eukaryotic cells has an intricate protein network that facilitates protein biogene-sis and homeostasis. The molecular complexity and sophisticated regulation of this machinery favours study-ing it in its native microenvironment by novel approaches. Cryo-electron tomography (CET) allows 3D im-aging of membrane-associated complexes in their native surrounding. Computational analysis of many sub-tomograms depicting the same type of macromolecule, a technology I pioneered, provides subnanometer resolution insights into different conformations of native complexes. I propose to leverage CET of cellular and cell-free systems to reveal the molecular details of ER protein bio-genesis and homeostasis. In detail, I will study: (a) The structure of the ER translocon, the dynamic gateway for import of nascent proteins into the ER and their maturation. The largest component is the oligosaccharyl transferase complex. (b) Cotranslational ER import, N-glycosylation, chaperone-mediated stabilization and folding as well as oligomerization of established model substrate such a major histocompatibility complex (MHC) class I and II complexes. (c) The degradation of misfolded ER-residing proteins by the cytosolic 26S proteasome using cytomegalovirus-induced depletion of MHC class I as a model system. (d) The structural changes of the ER-bound translation machinery upon ER stress through IRE1-mediated degradation of mRNA that is specific for ER-targeted proteins. (e) The improved ‘in silico purification’ of different states of native macromolecules by maximum likelihood subtomogram classification and its application to a-d.This project will be the blueprint for a new approach to structural biology of membrane-associated processes. It will contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamics of Weakly Bound Quantum Systems' under Seventh Framework.

assistant: **Concept**

This proposal entitled “Dynamics of Weakly Bound Quantum Systems” (DWBQS)  describes a joint collaborative academic project and exchange scheme between researchers from Norway, Sweden and France as beneficiaries and Argentina and India as participants. The first focus of the proposed program is on the theoretical challenges regarding transfer and breakup mechanisms in excited atomic and molecular systems.  We will study breakup and imaging of Rydberg atoms and molecules in laser fields and Rydberg like systems in collisions between ions. The ability to solve the time dependent Schrödinger equation in this regime results in new insights regarding novel quantum processes involving entangled particles. For interpretation of present and future experiments the need for parallel theory development cannot be overestimated.A second focus will be to develop new understanding for the atomic structure problem in Super Heavy Elements (SHE) based on experience of many body physics in systems like large clusters and quantum dots. The DWBQS group with its new collaborative constellation of theorists and experimentalists, atomic and nuclear physicists, has a background which is well suited to secure the achievement of the proposed goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Achieving the golden Grail in solid tumor treatment' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Macrophage therapy is promising for solid tumor treatment as these cells are continuously recruited into the tumor mass, even the most hypoxic regions. Our pioneering research demonstrated that macrophages are able to take up ferritins loaded with anti-cancer drugs, creating Macrophage-Drug Conjugates (MDCs), and transfer these to cancer cells and kill them, a phenomenon we named TRAIN. In my ongoing ERC Starting Grant PROJECT McHAP, we have proven that MDCs can be sucessfully used not only to treat solid tumors but also to induce subsequent resistance to the tumor re-challenge. Acquisition of resistance to tumor development after specific therapy is a 'Golden Grail' in oncology.Now we aim to turn the MDC technology into a commercial and social value proposition by confirming mechanisms of tumor-resistance in tumor-bearing mice and identify immune response. This is crucial to raise interest of and establish a co-development (or licensing) deal with big pharmas to realize commercialization and clinical uptake of our IP-protected MDC technology. During the ERC PoC project, we will perform high-dimensional spectral flow cytometry, spatial transcriptomics and single-cell transcriptomics of the tumor before and after MDC treatment to identify mechanisms of tumor-resistance and optimize our business case. This project will thus provide proof of concept for the immune activation after the MDC treatment and thus establish the viability, feasibility, commercialization and overall direction for our innovative MDC technology. This project will substantially contribute to bring our MDC technology to the market and clinical practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biological effects quality assurance in monitoring programmes' (BEQUALM), addressing dissemination and exploitation.

assistant: **Impact**

Background:The purpose of this project is to set up a measurement infrastructure for a group of existing marine biological effects monitoring techniques. This infrastructure will organise the circulation of reference materials, the conduct of intercomparison exercises, and the co- ordination of practical training workshops. The ultimate aim is to develop a quality assurance system over a period of three years, which can then become self- financing, perhaps as part of the QUASIMEME quality assurance programme for chemical monitoring procedures in the marine environment. The infrastructure will then be available for use by any fee-paying laboratory that wishes to contribute data to national and international marine monitoring programmes.The overall goals of the project are: - to develop appropriate reference materials or type collections; - to develop an infrastructure for assessing the comparability of data from individual laboratories; - to demonstrate that biological effects analyses are under statistical control and are of known quality.Objectives: The ultimate output of the BEQUALM programme will be as follows:a) An agreed set of protocols for biological methods used in marine monitoring;b) An agreement on acceptable limits of variation for the methods in question;c) A system for monitoring the output of Participating Laboratories and assessing their compliance with agreed quality standards;d) An understanding of the costs implicit in running such a QA programme;e) The establishment of a QA infrastructure which shall be continued as a self-funding service to European marine monitoring programmes.Work programme: The following techniques will be covered by BEQUALM: - Water and sediment bioassays - Metallothionein measurement in fish - ALA-D activity in fish - DNA adduc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Boronic acids as building blocks for construction of molecular nanostructures and polymeric materials' under Seventh Framework.

assistant: **Concept**

This project describes the design and syntheses of new classes of boron-based compounds such as macrocycles, cages, and polymers, made by multicomponent self-assembly through simultaneous condensation of boronic acids with other molecular building blocks. The central goal is the formation of new materials with high porosity and low crystal density. Molecularly defined compounds such as macrocycles and cages can form porous solid state structures upon removal of encapsulated guest molecules (e.g. residual solvent molecules). Similarly, 2- and 3-dimensional polymeric networks may form porous structures if the geometry and the rigidity of the molecular building blocks are correctly chosen. Compared to classical approaches, which involve transition metals, our materials will display rather low densities because we will exclusively use molecules composed of light elements such as B, C, N, and H. This should result in intrinsic advantages for potential applications (e.g. gas storage).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MagNEO: Advanced additively manufactured permanent Magnets for New Energy and MObility Applications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

MagNEO's objective is robust and sustainable REE-free permanent magnets (PM) for emergent energy & mobility applications. The concept hinges upon novel compositions of AlNiCo & HEAs undergoing similar spinodal decompositions, processed by additive manufacturing (AM). The recycling strategies developed will allow environmentally friendly repurposing of disparate metallic constituents, with emphasis on Co recovery. The targeted properties of the new PMs are (BH)max ≥60 kJ/m3 for Co ≤24% and (BH)max ≥72 kJ/m^3 for Co≤35%.MagNEO will be realised through the following strategies: 1) open-source modelling tools, machine learning guided high-throughput digital & experimental screening to accelerate the development of novel environmentally benign materials, with compositions suitable for AM, throughout multicomponent alloy phase spaces, 2) harness the competitive advantages conferred by AM, such as shape complexities and microstructure engineering, in tandem with comprehensive heat treatment. These will be crafting novel anisotropic microstructures characterized by higher coercivity, culminating in (BH)max values exceeding 60 kJ/m^3.The performance of the new PMs will be verified for a) low-speed PM generators in wind turbines & ship propulsion shafts, (b) high speed (>100 m/s) rotors in heat pumps and (c) ABS sensors & headlight systems in automotive. The upscaling process will be conducted through techno-economic analyses performed by the manufactures in synergy with the end-users. This procedure will begin with a proof of concept at TRL3-4 and will culminate with technology validation at TRL6. MagNEO stands out as a fusion between accomplished multidisciplinary experts who will contribute to training and joint actions with other European teams to increase the competitiveness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Semantically-enabled Heterogeneous Service Architecture and Platforms Engineering' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of SHAPE is to support the development and realization of enterprise systems based on a Semantically-enabled Heterogeneous Service Architecture (SHA). SHA extends service-oriented architecture (SOA) with semantics and heterogeneous infrastructures (Web services, agents, Semantic Web Services, P2P and grid) under a unified service-oriented approach.<br/>To achieve this, SHAPE will develop a model-driven engineering (MDE) tool-supported methodology. SHAPE will take an active role in the standardisation of metamodels and languages for SHA. The technical results will be compliant with the proposed standards to ensure high industry acceptance.<br/>In current SOA approaches, business requirements and technical details are intertwined constraining the evolution of service-oriented business solutions. SHAPE will provide appropriate metamodels and languages, methods and tools to separate the different viewpoints of SOA for the development of semantically-enabled, flexible and adaptive business services on a rich SHA infrastructure. SHAPE addresses the target outcomes of the objectives in ICT-2007.1.2.<br/>The work in SHAPE will be organised in seven work packages: Industrial use cases, Model-driven methodology and architecture, Metamodels and languages, Modelling tools and services, Model transformations and deployment, Standardisation, dissemination and exploitation, and Project management.<br/>The SHAPE consortium consists of six research and technology partners and two industrial users: SINTEF with expertise on MDE and software architectures, ESI with expertise on MDE, SAP with expertise on SOA technologies, SOFTEAM with expertise on MDE methods and tools, DERI with expertise on Semantic Web Services, DFKI with expertise on enterprise modelling and agent technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advancing the physical intelligence and performance of roBOTs towards human-like bi-manual objects MANipulation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The MANiBOT research aims at bi-manual mobile robots, able to perform a wide variety of manipulation tasks with highly diverse objects, possibly partly or fully unknown beforehand, in a human-like manner and performance. To achieve this, we advance and fuse all necessary technologies, from multimodal perception, cognition and control, to novel cognitive mechatronics. We develop new environment understanding and object/pose recognition methods, empowered through adaptive, context-aware fusion of vision, proximity and tactile sensing and emphasizing on adequate efficiency for fast and effective manipulation, even of objects without precise model, including deformable ones, and in diverse, challenging environments with human presence. We also develop a novel suite of manipulation primitives including non-prehensile manipulations, which along with bi-manual manipulation will allow the transfer of diverse objects with various sizes, weights, shapes, materials and rigidities from a mobile robot, with performance close to that of humans, even upon significant spatial constraints. The above are fused through a novel approach for robot cognitive functions based on multi-level robot cycles that allow learning, composing and swiftly adapting robot behaviors for complex manipulations, covering key topics of sequential manipulation of multiple objects to achieve complex goals. We push the limits of physical intelligence of bimanual mobile robots by coupling our methods with novel cognitive mechatronics, fusing advanced tactile and proximity sensors with a bi-manual mobile manipulator, optimized for energy efficiency and increased autonomy, including HRI capabilities for trustworthy and efficient operation. Our outcomes will be evaluated in four use cases, in three pilot sites (TRL5)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Acoustic research on turbocharged engine modelling of exhaust and inlet systems (ARTEMIS)' in the context of a Fifth Framework call.

assistant: **Objectives**

Traffic noise is the most important environmental noise source in Europe. As many as 25 % of the population in Europe is exposed to transportation noise with an equivalent sound level over 65 dB(A). It is a clearly stated goal of the GROWTH work programme to reduce the pass-by noise to 70 dB(A) for automobiles and 74 dB(A) for heavy vehicles. Reduction of the noise from exhaust and inlet systems is essential for reaching the pass-by noise targets. Improved simulation programs for predicting the noise generation caused by unsteady flow in exhaust and inlet systems are very important for this purpose as well as for reducing the amount of experimental testing needed to develop a new product. The main objective of the project is to develop the models needed for computational tools to predict sound generation from turbocharged engine exhaust and air inlet systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intelligent Air Monitoring Network' (INTAIRNET) under Fifth Framework.

assistant: **Objectives**

There is a growing concern in the European Union (EU) about the consequences of urban air pollution on public health. Although every EU country has been instructed to establish a network of air control stations in its cities, the limited number of these expensive fixed stations and the lengthy air sampling and data collection/processing does not allow fast dissemination of this information to the public. The objective of this project is to provide the EU with a cost-effective, upgradeable, user-friendly and intelligent air monitoring network covering Europe, and capable of meeting the 2005 air quality requirements. This dynamic network will, through the Internet via websites, not only inform on quasi real time the European citizens of air quality status anywhere in the EU, but also help the decision-makers to more effectively manage urban air quality. Fabrication of mobile and communicating (GSM/GPS) microstations will integrate low-cost, sensitive gas sensors based on nanostructered metal oxide materials.Objectives:The overall objective of this project is to provide the EU with a cost-effective, upgradeable, user-friendly and intelligent air monitoring network (mobile and communicating microstations) covering the whole European continent, complementing existing fixed air control stations, and capable of meeting the 2005 air quality requirements. This dynamic network will, through the Internet, not only inform on quasi real time the European citizens of air quality status (maps of NO2, NO, O3, CO, CO2 concentrations) anywhere in the EU, but also help the decision-makers to more effectively manage urban air quality by controlling factors such as road traffic, and also help scientists to refine mathematical predictions of urban air pollution in cities.Milestones: Main mil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Intelligent Grid Platform' (IGP) targeting Horizon 2020.

assistant: **Abstract**

The energy sector is going through a transformation from a one directional centralized system in which energy is produced by a limited number of big power plants into a highly decentralized ecosystem due to the introduction of small-scale renewable energies and the electrification of mobility. In this situation, power distribution grid operators’ current workflows and IT systems cause inconsistent data management which complicates their planning and operation activities. Therefore, essential grid planning and operation workflows involve significant manual input. As a result, e.g. the evaluation of a connection request for a single new wind turbine often takes multiple days. Additionally, Smart Grid Technologies cannot be used to their full extent to avoid curtailment of renewables in congestion management, and to substitute conventional expensive grid capacity expansions.We have developed the Intelligent Grid Platform (IGP), the only integral software solution using machine learning algorithms to allow grid operators to reduce their operational and network expansion investment costs by giving them the means to clean and connect their data, digitize and automate their grid planning and operation activities and to more easily integrate smart grid technologies to help their operation processes and avoid expensive network capacity extensions. As a result, they save time and engineering resources by up to 70% and reduce grid operation and expansion costs by 40% to 60%. In this project, we will advance the IGP applications for online gird operation.