RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exponential Amplification and Rapid Detection of miRNAs using DNA-Quantum Dot Bioconjugates for Disease Diagnostics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Accurate and timely diagnosis is critical in the treatment of all diseases. Researchers are constantly discovering new links between specific biomolecules and diseases, often uncovering ‘panels’ of markers with high sensitivity and specificity for disease diagnostics. However, our current diagnostic tools are unable to take advantage of these panels as they lack sensitivity, or are too costly and slow for practical application. Accordingly, new technologies that can help transform these fundamental discoveries into revolutionary clinical tools are in high demand. These must be rapid, efficient, robust and cost-effective. To this end, I will develop a new rapid diagnostic assay that combines the unique functional properties of fluorescent nanomaterials and enzymes. The core technology is an advanced nanoparticle-biomolecule construct consisting of highly fluorescent ‘quantum dot’ inorganic nanoparticles coated with DNA. These nanobioconjugates (termed ‘AmpiDots’) act simultaneously as both templates for isothermal amplification of target miRNAs and as highly sensitive fluorescent sensors. The result will be a rapid, highly sensitive, versatile and efficient assay that can detect multiple targets simultaneously and give a robust signal for assay readout. A critical aspect of the work will be the use of advanced microfluidic-based analytical systems to optimise the assay and to study the unique phenomena that arise when enzymes interact with nanoparticles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Geometric constraints and feedback during tissue morphogenesis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

During development, cell movements and shape changes give rise to complex 3D forms. What underlies the fidelity of morphogenesis? To date, much emphasis has been placed on understanding how genes and local mechanics drive cell shape changes and tissue scale morphogenesis. However, the roles of the geometric properties of a tissue and its physical boundaries, their size, dimensionality, curvature and overall shape have recently emerged as important yet overlooked features of morphogenesis. This interdisciplinary project will unravel how geometry and geometric feedbacks constrain lower scale cell mechanics and how they contribute to tissue morphogenesis.We will study the interplay between geometry and active mechanochemical processes in two systems where physical boundaries constrain and guide morphogenesis. In Drosophila embryos, polarized tissue flow and a wave of tissue invagination depend on interactions with the surrounding egg envelope called the vitelline membrane. This envelope imposes tissue curvature, forms a rigid adhesive substrate, and confines the diffusion of molecules within the extra-embryonic fluid. Likewise, formation of the wing during metamorphosis in the pupa is associated with a dramatic expansion of the tissue surface within a rigid pupal sac forcing a complex tissue packing without compromising flatness in adulthood. The mechanics of tissue flow and expansion are unknown. How flows within these constraints give rise to folding needs to be characterized. These two systems share key similarities: their dynamics depend on the flow, expansion and folding of tissue layers, and 3D deformations are driven by internal active stresses and external constraints from rigid boundaries. In both cases we will dissect the mechanochemical active processes driving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neoliberal Terror: The Radicalisation of Social Policy in Europe', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project is the first to systematically investigate the introduction of counterterrorism within Health and Social care across Europe. The longstanding separation of medicine and care from policing/intelligence in liberal societies has been superseded in the era of Countering Violent Extremism (CVE). This study explores the political, economic and discursive mechanisms behind this dramatic policy shift, as well as the consequences for medical ethics and society. The project makes a major research contribution by exploring the integration of counterterrorism within caregiving professions as an effect of neoliberalism, through a methodologically pluralist approach. The project also contributes to research on policy diffusion by tracing the spread of deradicalisation programs between member states and EU institutions, with special attention paid to uptake by Europe’s small states.The first stage of the project operates at the European policy level. Data analysis is performed on political, economic and social data from all member states to determine the extent to which neoliberalism affects CVE implementation. Policy diffusion dynamics are then illuminated through Critical Discourse Analysis of institutional speeches, policies, and the work of the EU's Radicalisation Awareness Network (RAN), which attempts to standardise counter-radicalisation practice in Europe. The second stage of the project explores the local implementation of counter-radicalisation in health and social care sectors of the UK; France; Norway; Finland; Croatia; and Lithuania. Interviews and site visits enable the research to investigate standardisation and variation in CVE practice within Health and Social Care. The final stage of the project embarks on participant research with persons referred to CV
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ultra-high density three dimentional DNA arrays for biosensing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Extra cellular, circulating nucleic acids – such as DNA or RNA – have been found as important biomarkers for identification and diagnosis of cancer and other diseases However, the detection of circulating nucleic acids is non-trivial because they often exist at very low concentrations in large volumes of body fluids.  Although many attempts have been tried for the detection of these biomarkers in recent years, including various nanostructure based sensors, there is still no approach in sight that could reach the desired sensitivity. Hence, there is a great need for a sensor which can effectively detect the diagnostically relevant (low) concentrations of circulating nucleic acids with a high degree of selectivity and sensitivity. In this project we propose a new platform for detection of nucleic acids; the aim of this project is to achieve a multi-layered filtering device, which allows effective filtration, purification and detection of biomolecules from complex biofluids.  The platform is based on implementation of ultra-high density 3D DNA arrays - which are made on a functionalized nanoporous substrate (nanoporous anodic aluminium oxide) – into a microfluidic device assay (so called FoRe assay, i.e combination of Forward and Reverse assays, which is consist of multiple filters, each capable of capturing specific target biomarkers from different sample). Pores are able capture the target molecules because locally the concentration of even a single target molecule in the pore is sufficient for binding and hybridization. The captured target molecules can then be detected by subsequent specific labeling using DNA-tagged gold nanoparticles (via hybridization), which will allow detection with single molecule sensitivity.  If successful, the scalable system will be used as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Investigation of the interplay between the developmental responses induced by growth hormones and the response to biotrophic pathogens'.

assistant: **Objectives**

Successful pathogens often induce plant developmental pathways to suppress plant defence. As a result, diseased plants frequently display symptoms such as hypertrophy, hyperplasia, hypocotyls elongation and increase of bushiness. Plasmodiophora brassicae is such a pathogen. P.brassicae is a biotrophic fungus, the causal agent of clubroot disease of brassica and Arabidopsis. This disease is characterized by the production of galls on the root of the plant. To produce the gall, the pathogen induces the local accumulation of two phytohormones: auxin and cytokinin in plant roots. These hormones activate the division and the enlargement of meristematic root cells resulting in the production of this “new organ”. Previous studies demonstrated that auxin and cytokinin are able to suppress the induction of salicylic acid (SA), which controls the main defence pathway against biotrophic pathogen.  Using both pathogen-free and Arabidopsis-P.brassica experimental systems, I aim to understand the mechanism by which auxin and cytokinin interact with SA signalling in roots, and how the induction of a developmental program interferes with SA signalling. I will first examine which parts of the auxin and cytokinin pathways are required to suppress SA and to promote P.brassicae virulence. In addition to the perception of phytohormones (auxin and cytokinin for example) the induction of the developmental program is controlled by the presence of “master regulator”, often transcription factors, and epigenetic modification of the DNA. Thus, next, I will examine the involvement of the key transcription factors and epigenetic modification in the suppression of SA signalling and in P.brassicae virulence. The project will improve our knowledge on the cross talk between growth hormones and plant def
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantum energy storage and transfer' (QUEST) under Horizon Europe.

assistant: **Objectives**

Energy management has always been crucial, throughout history, in advancing technology, enhancing productivity and fostering sustainable development. It is thus not surprising that even now, at the verge of the second quantum revolution, the field of quantum thermodynamics is emerging as one of the most vibrant branches of quantum many-body physics. A key focus of this research area is the conversion of heat, work, and information within quantum systems and, as a consequence, the conceptualization of quantum thermal machines, such as quantum thermal engines, refrigerators, and quantum batteries, which leverage quantum effects like superposition, entanglement, and coherence to extract and transfer energy between quantum systems. Among these, quantum batteries stand out for their potential to achieve faster and more efficient charging processes compared to their classical counterparts, as demonstrated by pioneering studies on the realization of the quantum Dicke battery, which showed a collective speedup of the charging process. These outstanding results have motivated a growing interest towards these quantum technologies. However, despite significant progresses, the field still faces numerous challenges, including stabilization of stored energy, optimization of charging protocols, and enhancement of energy transfer. Within this context, the limitations of current simulation techniques, which often rely on exact diagonalization, restrict the exploration of larger and more complex systems, particularly in higher dimensions. Therefore, as energy management continues to be pivotal in technological advancements and sustainable development, QUEST seeks to address the need for breakthroughs in the development of quantum energy devices, advancing the current state-of-the-art in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DESIGN STUDY FOR A EUROPEAN INFRASTRUCTURE ON ADVANCED GENOMICS TECHNOLOGIES' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Innovation in the genomics field is extremely intense and requires high up-front investments. The toolbox of sequencing platforms with unique features that require specialized training and leverage extensive cross-functional expertise, is rapidly expanding. The EASIGEN-DS project evolves from two EU infrastructure projects that have proven to be very successful in providing access to cutting-edge DNA sequencing technologies to hundreds of researchers. Here, we propose to carry out a design study for establishing a new European Research Infrastructure on Advanced Genomics Technologies, EASIGEN. In order to develop an excellent scientific, technological and operational design, we will conduct landscape studies, stakeholder consultations, and community surveying. In parallel, we will seek for the support and commitment of several national and EU stakeholders and user communities through a multi‐faceted dissemination plan. We envision that EASIGEN will encompass: 1) a Technology Platform that will offer state-of-the-art genomic analysis methods, such as single-cell genomics, spatial genomics and long-read sequencing, as well as population-scale genomics capacity; and 2) a Support Platform that will provide standardization tools, training, co-innovation with industry, and consulting for smaller facilities, including those in widening countries. Both platforms will serve a vast community of users from the health, biomedical and life science fields. The consortium brings together 1) a network of eleven genomics facilities with distinct application specialities. and an aggregated sequencing capacity of >450,000 human genomes per year; 2) four partners with specific and crucial expertise: data stewardship, ethical, legal and social implications, socio-economic impact and innovat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular crystals' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Solid state supramolecuar chemistry and crystal engineering are flourishing fields of research in modern chemistry practised by scientists with interests in the modelling, design, synthesis and applications of crystalline solids with predefined and desired aggregation of molecules and ions. Modern crystal engineering occupies a precise place at the interface between the supramolecular and solid-state sciences. In this sense, it lies at the intersection of the top-down and bottom-up approaches towards materials design and fabrication. Solid-state supramolecular chemistry and crystal engineering are, therefore, highly interdisciplinary and attract contributions from many traditional areas: organic chemistry, inorganic and organometallic chemistry, theoretical chemistry and crystallography. An ever-increasing number of scientists are directing their attention towards solid-state chemistry both as a means of developing sophisticated devices, and to learn how to control self-assembly and molecular recognition. Implicit in all this is an attempt to understand fundamental issues of nucleation and crystal growth. The two meetings are intended to foster the development of interdisciplinary research programmes in crystal engineering and solid-state supramolecular chemistry and to assist dissemination of results, cross-fertilization", and generation of new "hybrid" ideas in the areas of molecular materials. For these reasons we believe that a series of two conferences would provide a very useful and timely opportunity both for established scientists, willing to discuss recent results and to compare scientific strategies informally, and for younger scientists interested in learning where the frontier of crystal engineering are likely to be in the future.The selected speakers will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Geothermal Exploration and Optimization through Forward Modeling and Resource Development' in the context of a Horizon Europe call.

assistant: **Objectives**

GO-Forward aims to develop a novel methodological approach to make more accurate pre-drilling predictions of geothermal reservoir properties and thus reduce the mining risk. Key to the GO-Forward approach is to simulate geological processes for pre-drill assessment of reservoir structure and properties, calibrated to geological or geophysical data, rather than extrapolating the properties from those data with geostatistical methods. To this end, GO-Forward focuses on extending and further developing, testing and demonstrating the added value of forward modelling methods originally developed for hydrocarbon exploration, including stratigraphic forward modelling (SFM), diagenesis forward modelling (DFM) and fracture network forward modelling (FFM), to be used for exploration in different geothermal settings of high relevance for Europe. First, the developed approaches will be tested and calibrated in areas with abundant subsurface information and production data, to prove conceptually the applicability of the methods and reproducibility of the results, to optimise and de-risk geothermal exploration. Calibrated model approaches are subsequently applied in areas with limited data availability to demonstrate their capability to increase pre-drill Probability of Success (POS). To support the workflow and further reduce exploration costs, GO-Forward advances ML-based and computational methods to enhance (existing) (sub)surface information for calibration, uncertainty quantification and data assimilation, and (upscaling) routines for flow simulation, DNSH, and techno-economic performance assessment for POS and Value of Information (VOI).  In addition, GO-Forward addresses public awareness of geothermal developments already at the early stages of exploration. By including novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Network management of traffic monitoring infrastructure' (CAG).

assistant: **Innovation**

The Internet has emerged into an integral part of our daily lives, for this reason its solid operation and performance is of paramount social, economical, technological, and scientific importance. To guarantee the solid operation of the Internet, network operators rely on network monitoring, and especially traffic monitoring, devices that collect essential network data that are later used by management systems to analyse and optimise network performance.This proposal is going to research the problem of having an autonomic, independent control system for managing traffic monitoring devices in IP networks. It will focus on the research problems surrounding the autonomic management of monitoring devices; on the design of a control interface for managing such devices; on new innovative methods of processing monitoring data; and on the implementation and evaluation of this interface. This research falls within the greater context of the Internet measurements and autonomic computing research areas. The former seeks to develop techniques for effectively collecting and analysing Internet data, while the latter seeks to develop techniques for automating the management of networks.The proposed research is related to the background of the researcher that has a primary focus on the Internet measurements research area. Moreover, it will enable the researcher to return to a high quality European academic institute in his home country and to work with researchers that have substantial experience on conducting research in the autonomic computing research field. Thus, the proposal combines the strengths of the researcher and of the host institute in order to research a state-of-the-art multidisciplinary problem. Moreover, it will facilitate the reintegration of the researcher in the Eur