RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Artificial Lanthanide Enzymes for Selective Photocatalysis:  'Enlightening' Metalloenzyme Design and Evolution' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Enzymes are efficient and selective biocatalysts. They are in high demand in chemical and pharmaceutical industry, as they facilitate more sustainable production processes. However, it remains challenging to develop novel enzymes that catalyze reactions beyond nature's synthetic repertoire. To tackle this problem, I propose a fundamentally new approach that merges metal-dependent chemical photocatalysis with enzyme engineering. Photoexcitation is a powerful catalytic tool. It enables alternative modes of substrate activation by generating radical intermediates. Controlling these reactive species to confer regio- and stereoselectivity, however, is a major challenge in synthetic chemistry. The key idea of this proposal is thus to perform photocatalytic reactions inside the chiral environment of artificial metalloproteins, which can be optimized efficiently by directed evolution. My group recently established the formation of lanthanide-protein complexes from highly stable, computationally designed protein scaffolds. Based on this work, we now aim to engineer a photoenzymatic platform for synthetically valuable chemistry. The main goal is to implement and optimize lanthanide photocatalysis in these proteins to facilitate stereoselective C-H activation and C-C bond forming reactions. Moreover, a fundamental mechanistic understanding how such new photocatalytic function emerges in proteins will be crucial for enzyme engineering. To that end, I propose a strategy that mimics natural evolution in a two-step process. Starting from libraries of naive small proteins, a high-throughput screen will first identify lanthanide binders, which are then exposed to a selection system that couples the survival of a bacterial host to an enzymatic detoxification reaction. PhotoLanZyme will y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Translational Research in Autoimmunity' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Chronic autoimmune diseases represent a clinically heterogeneous group of disorders that are characterized by the presence of a chronic inflammatory process localized in various organs and tissues. Though distinct types of autoimmune diseases are rare, they collectively affect millions of individuals worldwide (roughly 3% of the global population); as they often strike younger subjects, they are frequently responsible for permanent organ damage, thus constituting one of the leading causes of chronic disability, thus entailing a significant socioeconomic burden. The specific modulation of the triggering phase of the immune response represents the avenue of future treatment approaches for autoimmune diseases. Translational Research in Autoimmunity seeks to create a direct pipeline between cutting edge basic research and clinical applications, in order to streamline as much as possible the delivery of a product (or products) from the conception stage to the design of clinical trials. The meeting will represent the occasion to identify and benchmark, on the basis of our current knowledge, the most promising, multidisciplinary platforms to deliver laboratory breakthroughs to clinical settings for the effective immunoregulatory treatment of autoimmune diseases. Furthermore, as a consensus-building initative, it will contribute to the set up of a group of researchers willing to cooperate in the long term on projects which have the final aim of discovering new immunoregulatory treatments for chronic inflammatory (autoimmune) diseases.Practical outcomes of this meeting will include: 1) creation of a top level group of scientists willing to cooperate on several feasible projects; 2) generation of a patrimony of treatment-oriented ideas to be developed; 3) the possibility of launc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'An advanced surveillance platform to improve the EURopean Multi Authority BordeR Security efficiency and cooperation'.

assistant: **Concept**

Security risks and threats in the maritime domain are becoming increasingly more complex day by day. Within the EU there have been significant increases in irregular migration flows and human trafficking and smuggling but also of other illegal activities, such as drugs and arms trafficking and illegal, unreported and unregulated fishing, and –according to the FRONTEX “Risk Analysis for 2021” report- the challenge becomes even bigger. The European Union Maritime Security Strategy, and other EU initiatives such as EUROSUR and CISE, highlight that closer collaboration between authorities at national, regional and EU levels can constitute the key action to increase both situational awareness and operational efficiency. In particular, there is increased interest in assessing the viability of multi-authority cooperation in (especially high altitude) sensing and capability advancement for enhanced wide area surveillance of land, air and sea borders. EURMARS’s ground-breaking vision is to expand the common risk assessment practices currently deployed by authorities to enable the development, deployment and evaluation of a secure multitasking surveillance platform that improves sensing capabilities for a wide range of security risks and threats in wider border areas by clustering high altitude platforms technology, satellite imagery, UxVs and ground-based sensors into a novel joint surveillance capability. As part of the EURMARS framework, the various existing and future systems for maritime surveillance will be integrated, to allow for the collaborative operation and the provision of the sensing results to related authorities. The open architecture will build on the lessons learnt of previous initiatives, assimilate the knowledge of the stakeholders and their practice on CISE a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Gene networks in cortical interneuron development: modeling interneuron function in health and disease'.

assistant: **Concept**

The neural assembly underlying the formation of functional networks in the cerebral cortex constitutes one of the most complex neuronal systems in the brain. Much of this complexity arises during development through the interaction of two distinct neuronal types, the glutamatergic projection neurons and g-aminobutyric containing (GABAergic) interneurons. Recently, interneuron dysfunction has been associated with severe neurological and psychiatric disorders (e.g. epilepsy, schizophrenia and bipolar disorder). In order to achieve true progress in the understanding of cortical development and of neurological diseases associated with cortical interneuron dysfunction, a complete account of the development of its neuronal constituents is essential. In that sense, despite the detailed picture that is emerging about the development of cortical projection neurons, the mechanisms underlying the development of interneurons in the cerebral cortex have remained poorly defined. The general goal of the network is to obtain a comprehensive definition of the cellular and molecular mechanisms controlling the development of cortical interneurons. To reach this aim, we will take a multidisciplinary approach by combining novel bioinformatic and genomics applications, cutting-edge imaging techniques, and conventional cellular, molecular and electrophysiological methodologies. In addition, we will develop new genetic tools to engineer developmental models of cortical disorders involving interneuron deficiency. Thus, successful execution of the project will result in: i) New knowledge of the mechanisms underlying the specification, migration and terminal differentiation of cortical interneurons, and ii) Generation of new developmental models of cortical disorders resulting from interneuron de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Prediction error computation in visual perception' (PreVision).

assistant: **Innovation**

Prior knowledge plays a central role in shaping our perception and interactions with the world. Predictive coding theories represent an influential framework formalizing the neural computations that underlie the integration of prior knowledge into perception. One central tenet of predictive coding is the computation of prediction errors, which signify the discrepancy between predictions, derived from our prior knowledge, and incoming sensory input. Despite ample empirical evidence supporting the existence of prediction errors, such as heightened sensory responses to unexpected compared to expected stimuli, several unresolved questions persist.One pivotal question pertains to the nature of the surprise encoded in sensory prediction errors across the visual cortical hierarchy. Does the computation of prediction errors reflect local surprise, specific to each level in the visual hierarchy (e.g., surprising orientations in primary visual cortex)? Alternatively, is the coding of surprise inherited top-down, aligning with the notion of predictive coding that predictions are relayed from higher to lower areas? Furthermore, it remains unclear whether the computation of surprise dynamically adapts to our goals or remains a static feature of cortical tuning. Lastly, the networks and temporal dynamics that underlie prediction and prediction error computations are poorly understood.Within the scope of the PreVision project, my objective is to address these critical knowledge gaps through the integration of advanced neuroimaging techniques and artificial intelligence methodologies, thereby shedding light on the fundamental neurocomputational mechanisms that drive perception. Consequently, this project represents an excellent opportunity for me to engage in innovative and pioneering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cooperative Situational Awareness for Wireless Networks' to be submitted under Seventh Framework.

assistant: **Abstract**

Devices in wireless networks are no longer used only for communicating binary information, but also for navigation and to sense their surroundings. We are currently approaching fundamental limitations in terms of communication throughput, position information availability and accuracy, and decision making based on sensory data. The goal of this proposal is to understand how the cooperative nature of future wireless networks can be leveraged to perform timekeeping, positioning, communication, and decision making, so as to obtain orders of magnitude performance improvements compared to current architectures.Our research will have implications in many fields and will comprise fundamental theoretical contributions as well as a cooperative wireless testbed. The fundamental contributions will lead to a deep understanding of cooperative wireless networks and will enable new pervasive applications which currently cannot be supported. The testbed will be used to validate the research, and will serve as a kernel for other researchers worldwide to advance knowledge on cooperative networks. Our work will build on and consolidate knowledge currently dispersed in different scientific disciplines and communities (such as communication theory, sensor networks, distributed estimation and detection, environmental monitoring, control theory, positioning and timekeeping, distributed optimization). It will give a new thrust to research within those communities and forge relations between them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SUSTAINABLE MANAGEMENT AND APPLICATIONS FOR RESOURCE-EFFICIENT TECHNOLOGIES IN OLIVE'.

assistant: **Concept**

SMARTOLIVE aims to revolutionize olive production and processing through precision agriculture and digital innovation, enhancing sustainability and competitiveness. The project will integrate proximal and remote sensing technologies with AI-driven decision support systems (DSS) to optimize water and nutrient management, improve productivity, and enhance tree health. Smart traceability technologies will provide full transparency from orchard to bottle, strengthening consumer trust and market value. The main objectives include: (1) developing a multi-sensor framework to monitor tree water and nutrient status in real time, (2) implementing AI models to optimize orchard management strategies such as irrigation, nutrient application, fruit maturity assessment, and smart pruning, (3) establishing a blockchain-enabled system for smart traceability, and (4) validating these solutions through field trials for scalability and real-world applicability. The project will leverage a multidisciplinary consortium of academic institutions, industry partners, and agribusiness cooperatives, including key stakeholders from Argentina. This partnership aims to facilitate knowledge transfer and the adoption of sustainable agricultural practices in both European and low- and middle-income countries . Data from on-tree sensors, UAV imagery, and satellite remote sensing will feed predictive models to deliver actionable insights, promoting resource efficiency and climate resilience. The smart labeling system will provide consumers with authenticated information on product origin and quality. SMARTOLIVE aligns with Horizon Europe priorities on sustainable agriculture, climate adaptation, and digital transformation, supporting SDGs such as Zero Hunger, Industry and Innovation, Responsible Consumpti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COOLing electronic devices with GRAphene ELEctrons' (COOLGRAELE), addressing dissemination and exploitation.

assistant: **Impact**

Devices such as mobile phones, computers, and batteries have become an integrated part of our society. An important challenge in such devices and device components is to avoid overheating by using suitable thermal management. Currently, this typically relies on heat dissipation by electrons in metals such as copper. More recent approaches have explored heat dissipation by phonons in graphene and related materials, which can have a thermal conductivity that is an order of magnitude higher than that of typical metals. In this project, we aim to demonstrate thermal management technology, where heat dissipation takes place by graphene electrons, rather than phonons. This is a promising approach, as the thermal conductivity of graphene electrons can be another order of magnitude larger than that of graphene phonons, as we recently demonstrated in our ERC-funded research. Furthermore, it allows for direct electronic heat dissipation without the intermediate step via phonons.   The two main objectives of this project are i) to demonstrate graphene-electron-based heat dissipation in relevant electronic devices; and ii) to develop a business creation plan related to this technology. These objectives will be addressed by an experienced and multidisciplinary team consisting of scientists, technologists and business developers. On the technical level, we will fabricate and characterize three specific proof-of-concept demonstrator devices. On the commercial level, we will work on intellectual property protection, leverage our network of partners from relevant industries, and design a business creation strategy. There will be constant feedback between the technical level and the commercial  level of the project, in order to establish how the technology will create the most added valu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural and kinetic basis of evolutionary conserved and divergent microtubule plus end tracking mechanisms' to be submitted under Seventh Framework.

assistant: **Abstract**

In eukaryotic cells the microtubule (MT) cytoskeleton is of crucial importance for many essential cellular functions. The determination of cell morphology, intracellular transport, chromosome segregation in mitosis, and cell motility belong to the processes carried out by MTs. Aberrant cell morphology, developmental diseases and promotion of malignant transformations in animal cells are results of failures in these processes. The dynamically growing plus end of MTs is of special interest as it serves as a cellular hub integrating signals needed to regulate the MT cytoskeleton and its functions. Due to the plus end’s highly dynamic nature and the complexity of protein-protein interactions at the end, it is still unclear which structural transitions take place at microtubule ends and which structures are recognized by regulatory proteins that bind the growing ends selectively. This project aims at a mechanistic understanding of selective targeting of specialized proteins to microtubule ends that exhibit diverse functions there. Two layers of interactions at microtubule ends are addressed in this proposal: (1) We aim to elucidate the molecular origin for the conserved property of end binding proteins (EBs) to bind autonomously to the growing microtubule plus end region, which provides a dynamic platform for second-layer binding of more divergent proteins. (2) We aim to understand the logics underlying the less conserved interactions of these other microtubule associated proteins (MAPs) with EB-decorated MT ends. These two layers of the MT plus-end binding protein interaction network will be analyzed by a concerted, multidisciplinary experimental approach combining in vitro and in vivo experiments, using quantitative fluorescence microscopy to measure the dynamics of MT end
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Regulation of spore coat synthesis and assembly in bacillus subtilis' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Sporulation in Bacillus involves an asymmetric cell division. The mother cell subsequently engulfs the smaller forespore and they collaborate in developing the heat-resistant spore coat. Two key proteins which direct late events in the mother cell during sporulation are GerE and SpoVM. GerE is a 74 residue DNA-binding protein which acts as an activator and repressor of transcription. SpoVM is required for cortex and coat formation and plays a morphogenic role. I proposed to isolate the gerE gene from B. stearothermophilis and subclone it for overexpression. The recombinant protein will be purified, characterised in DNA binding assays and used in crystallisation experiments. The spoVM protein has been chemically synthesised and crystallisation trials can begin immediately. Training content (objective, benefit and expected impact) My background is in protein crystallography and it is my intention to continue working in structural biology. It is important for me to acquire recombinant DNA techniques for the overexpression and mutagenesis of genes encoding proteins of interest. The York laboratory combines expertise and facilities in molecular biology, protein biochemistry and crystallography. This proposal gives me training opportunities in recombinant DNA techniques. These, together with my present experience, will allow me to become an effective independent scientist able to identify and solve problems. Links with industry / industrial relevance (22) Not applicable