RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nematode-based screening technology for next-generation drug discovery' under Horizon 2020.

assistant: **Concept**

Alternative model organisms, such as worms or flies, are getting increasingly popular in the drug discovery field, since they are proving to be suitable for replacing mammals for several aspects of the screening tests in the pre-clinical phase. In this context, one of the most interesting models is a roundworm species, named Caenorhabditis elegans. Its microscopic size, however, hinders its actual use in the field, since the protocols for its maintenance and study still completely rely on manual handling/observation techniques, definitely lacking any reproducibility and throughput standards. The NeMatrix project proposes to fill this technological gap, by developing a microfluidic platform for fully automated culture and analysis of C. elegans –and, more in general, roundworms-, tailored for drug screening applications. Specifically, starting from a simple worm suspension, our envisioned prototype will employ a set of microfluidic-based automated operations to: (i) gently distribute nematodes within separate microcompartments; (ii) feed them at desired food rate, time and concentration; (iii) expose them to drug tests at desired rate, time and drug concentrations; (iv) continuously monitor multiple phenotypes over the whole worm population in the device; (v) provide real-time data analysis and store/exploit results in a “big data” approach. This project would provide one of the first examples of next-generation technologies for whole-organism drug screening, with the potential of paving the way for the widespread use of worms and other alternative model organisms for the replacement, reduction and refinement of animal testing in biomedical research and pharmaceutical industries. The project will be held in close collaboration with key industrial partners in the field, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Probabilistic and Dynamical Study of Nonlinear Dispersive Equations' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nonlinear dispersive partial differential equations (PDEs) appear ubiquitously as models describing wave phenomena in various branches of physics and engineering. Over the last few decades, multilinear harmonic analysis has played a crucial role in the development of the theoretical understanding of the subject. Furthermore, in recent years, a non-deterministic point of view has been incorporated into the study of nonlinear dispersive PDEs, enabling us to study typical behaviour of solutions in a probabilistic manner and go beyond the limit of deterministic analysis.The main objective of this proposal is to develop novel mathematical ideas and techniques, and make significant progress on some of the central problems related to the nonlinear Schrödinger equations (NLS) and the Korteweg-de Vries equation (KdV) from both the deterministic and probabilistic points of view. In particular, we consider the following long term projects:1. We will study properties of invariant Gibbs measures for nonlinear Hamiltonian PDEs. One project involves establishing a new connection between the limiting behaviour of the Gibbs measures and the concentration phenomena of finite time blowup solutions. The other project aims to understand the space-time covariance of the Gibbs measures in the weakly nonlinear regime.2. We will first construct the invariant white noise for the cubic NLS on the circle. Then, we will provide a statistical description of the global-in-time dynamics for the stochastic KdV and stochastic cubic NLS on the circle with additive space-time white noise.3. We will develop novel analytical techniques and construct the local-in-time dynamics for the cubic NLS on the circle in a low regularity.4. We will advance the understanding of traveling waves and prove scattering for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Models and Methods for an active ageing workforce: an international academy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Working populations in European Member States are ageing. In short, if most people continue to retire at around 60 years of age, the European labour force will shrink by around three million per year over the period 2020 to 2035 as reported by EU-OSHA. There is a need for a new and more comprehensive policy design to counter the shortage of workers in the future.Moreover in European production systems there is a growing demand of applications with arm-based robots, exoskeletons, smart and intelligent working tools, immersive virtual reality technology. All these last generation technologies if well applied have a big potential to preserve the productivity, quality and safety of the aging workforce by better powering their great level experience and extraordinary skills. The main objective of the MAIA Academy is to create a unique research and innovation staff exchange network focused on the ageing problem in manufacturing. MAIA project will provide a multidisciplinary approach to achieve objectives as:-The study of the aging workforce needs and requirements in European production and assembly systems;-The development of new design methodology to create assembly and production workspaces elderly-oriented by preserving productivity, quality and safety;-The development of new analytical models to support assembly and production line design elderly-oriented and validate them with world-wide case studies.-Design and test of new ergonomics devices in order to support aging workers during tasks, by helping them in reducing muscular fatigue and risk of muscle skeletal disorders-Design and test of new immersive and virtual reality instruments in order to guide elder workers and support them in the production process.MAIA will bring together 7 European partners and 6 Third countr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modified proteases for the reduction of felting and shrinkage of wool textiles' in the context of a Fifth Framework call.

assistant: **Objectives**

The market value of wool is limited by the fact that consumers place increasingly high demands on machine wash ability and soft handle. Felting, which is a typical property of wool due to the configuration of the scales of the wool fibre, is a serious problem, especially during washing. Chlorination, followed by polymer deposition, is commonly used to confer shrink-resistance, but this involves major drawbacks with respect to chlorine and the environment. The main aspect of this proposal is to develop a novel enzymatic process for producing machine washable wool by limiting the enzymatic degradation of wool fibres to their cuticle scales. The novel engineered enzymes will be developed to achieve this goal. The radically new bioprocessing regimes for wool scouring and finishing processes, and commercial products will be developed. This would be a major technological breakthrough to completely replace a hazardous chemical preparation and finishing route.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '3Os and IP awareness raising for collaborative ecosystems' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ZOOOM aims to raise awareness on the importance of IP generation and management in collaborative innovation ecosystems which rely on three key assets, software, hardware and data. Open software, hardware and data are essential for a sustainable, trustworthy and sovereign industrial ecosystem. However, lack of competences in matching business models with appropriate licensing frameworks prevents unlocking the full potential of emerging technologies.ZOOOM departs from the concept that achieving strategic autonomy and technological sovereignty is possible through a sound understanding of what open licensing strategies are the best match for specific business models. This includes knowing when and to what degree it makes sense to stay open, and when going proprietary is the best strategy.The project aims to reach three core target groups actors in innovation ecosystems: knowledge generators, innovation support organizations and key stakeholders. Knowledge generators will benefit from tools for learning and supporting everyday development, increase competences on open licensing strategies for IP management, disseminate the concept and facilitate the application of IP management by identifying and suggesting viable business models enabled by open licensing strategies. Supporting organizations will get tools for internal training, support material to empower their clients, identify formats or services able to increase the reach of the IP management concepts and a database of cases analysed under the lens of open licencing and business development. Key stakeholders will benefit from a white book suggesting an integrated EU approach to open licensing of software, hardware and data as intertwined components of the innovation policy. This will set the basis for further research on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BIsmide And Nitride Components for High temperature Operation' (BIANCHO).

assistant: **Concept**

BIANCHO will develop photonic components designed to significantly reduce power consumption at the component and system level in advanced communication systems, thereby  saving significant electricity, and enabling unlimited bandwidth through integration, more optical processing and very high spectral-density photonic transmission.<br/>Current telecomm components suffer severely from intrinsic losses. Around 80% of electrical power is wasted in a 1.55?m laser chip as heat. Most systems require thermo-electric coolers and an air-conditioned environment, further increasing the energy budget by over an order of magnitude. The losses are due to Auger recombination in semiconductor lasers and optical amplifiers (SOAs), and due to the temperature dependence of the energy gap in electro-absorption modulators (EAMs). Incremental approaches to overcome these problems have reached their limits. We propose a radical change, to manipulate the electronic band structure of novel dilute bismide and dilute nitride alloys of GaAs and InP to eliminate Auger recombination and dramatically reduce the temperature dependence of the energy gap. This allows us to research, develop, test and demonstrate uncooled EAMs, highly efficient uncooled lasers and SOAs. These properties are also highly beneficial for high speed photodiodes as required in transceivers, as will be demonstrated.<br/>BIANCHO brings together leading European groups with complementary expertise in epitaxy, device physics, band structure modelling and advanced design and fabrication, in a well focused consortium of exceptionally high quality. The project will strongly emphasise the protection of intellectual property and aggressive dissemination of results to maximize their impact. The team includes a key European component man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integration and adaptation of impaired mitochondrial fitness in orchestrating T cell dysfunction in the tumor microenvironment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cancer immunotherapies harnessing the tumoricidal activity of tumor-reactive T cells represent a major breakthrough in the current paradigm for treating cancer patents. However, the highly immunosuppressive tumor microenvironments found in solid tumors present challenges by restricting the tumoricidal functions and metabolic fitness of infiltrating tumor-reactive T cells. Given that the activation-induced metabolic switch is tightly intertwined with T cell activities, restoring the metabolic fitness of T cells represents a promising strategy for strengthening anti-tumor immunity. However, the success of this strategy relies on our understanding of the underlying mechanisms utilized by tumor cells to abolish the metabolic fitness of T cells, and of how metabolic programming controls T cell functions. Based on our preliminary results, we postulate that tumor cells disrupt the mitochondrial dynamics of tumor-infiltrating T cells by interrupting mitophagy. This causes a metabolic crisis for the infiltrating T cells in sustaining their metabolic fitness and flexibility. Furthermore, we hypothesize that declined mitochondria-derived retrograde signals resulted from mitochondrial dysfunction may lead to T cell dysfunction/exhaustion and altered immune responses through epigenetic reprogramming and altered proteome-metabolic regulatory circuits. The objectives of this proposal are to delineate how tumor cells influence the mitochondrial dynamics of T cells and define the unexplored immunometabolic regulations of T cell functions that are controlled by mitochondria. Lastly, we aim to new methods to restore missing retrograde signals in T cells, which could allow them to prevent mitochondrial dysfunction-induced epigenetic and transcriptomic changes. This work represents an entir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Efficient Micromachining of Ceramic Materials in free formed, accurate and reliable shapes' (2007-2013).

assistant: **Concept**

Technical ceramics (Al2O3, ZrO2, SiC, Si3N4) have received increasing attention in the recent years and they significantly contribute to sustainable growth and development. However, their extensive use throughout industry is still hindered by the lack of efficient technologies enabling to provide accurate and free formed components without defects. Near/net-shape manufacturing techniques have mayor benefits (mass production, different size available and versatile shapes). However, the accurate control of properties, surface characteristics and dimensions of the finished parts is still crucial. This challenge is even more evident for microscale applications. Emanating from these considerations, the main target of MiCMa3 is to identify the new micromanufacturing technologies for the accurate and reliable micromachining of free formed features and ceramic components. The investigated technology families will be EDM (Electrical Discharge Machining) and HSM (High Speed Milling).  Micro-EDM capabilities have been improved to a large extends in the last decades. Furthermore, spark erosion is a potential and attractive technology for the machining of ceramics, once a sufficient electrical conductivity is provided to the base material. In this context, the competitiveness of micro-EDM in the processing of ceramic composites will be investigated and the project will develop process parameters and strategies for the micro EDM-manufacturing of a selected group of ceramic composites (objective 1).  In the domain of mechanical cutting process, High Speed Milling (HSM) has been recently introduced as the key answer for the machining of brittle materials; the feasible machining of marble stone and technical ceramics has been demonstrated. In this context, the project will explore the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Probing the relevance of carbene binding motifs in enzyme reactivity' under Seventh Framework.

assistant: **Concept**

Histidine (His) is an ubiquitous ligand in the active site of metalloenzymes that is assumed by default to bind the metal center through one of its nitrogen atoms. However, protonation of His, which is likely to occur in locally slightly acidic environment, gives imidazolium sites that can bind a metal in a carbene-type structure as found in N-heterocyclic carbene complexes. Such carbene bonding has a dramatic effect on the properties of the metal center and may provide a rational for the mode of action of metalloenzymes that are still lacking a solid understanding. Up to now, the possibility of carbene bonding has been completely overlooked. Hence, any evidence for such His coordination via carbon will induce a shift of paradigm in classical peptide chemistry and will be directly included in basic textbooks. Moreover, this unprecedented bonding mode will provide access to unique and hitherto unknown reactivity patterns for artificial enzyme mimics. Undoubtedly, such a break-through will set a new stage in modern metalloenzyme research. A multicentered approach is proposed to identify for the first time carbene bonding in enzymes. This approach unconventionally combines the current frontiers of organometallic and biochemical knowledge and hence crosses traditional boarders. Specifically, we aim at probing carbene bonding of His by identifying reactivity patterns that are selective for metal-carbenes but not for metal-imine complexes. This will allow for efficient screening of large classes of metalloenzymes. In parallel, active site models will be constructed in which the His ligand is substituted by a heterocyclic carbene as a rigidly C-bonding His analog. For this purpose chemical synthesis will be considered as well as enzyme mutagenesis and subsequent carbene coordi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of high precision isotope ratio measurement methods using multi-collector ICP-MS' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Objetive of the Project. The objective of the project is to develop analytical procedures, using isotope ratio methods, which may be applied to a number of important industrial and research areas of activity. These procedures are intended to enhance the competitiveness of European Industry, and provide a new tool for European Research Institutions. The areas which will potentially benefit from the results of the project will be: 1. Mineral and oil exploration and resource management. 2. Handling of materials involved in the Nuclear Power and Reprocessing industries. 3. Environmental monitoring activities. 4. Nutritional Sciences. Proposal Content. In order to achieve this objective, the following work programs will be carried out. a)Design and construction of a new generation ICP-MS instrument incorporatinga thermalisation hexapole collision cell, laminated magnet (for stable but rapid scanning) and an extended multiple collector system. b)Design of a new excimer laser ablation system and associated stage which will be coupled to the new instrument. c)Distribution of the prototype instrument to selected partners who will develop the experimental methods required for the exploitation of the novel instrumentation . A number of specific activities have been identified which are felt to be important areas of development which should produce results which are of immediate use in the designated areas. d) Development of the software necessary to automate the methods developed in(c). e)Development of sample handling methods, especially those relating to laserablation of solids so that direct isotope ratio and composition measurements can be made on the same instrument. f)Continue the development of the ICP- vacuum interface based on collision-celltechnology to further enhance t