RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A game-changing booking website designed to help 1bn people with a disability enjoy accessible accommodation that can suit their specific needs and allow them to travel worry-free' (Handiscover).

assistant: **Innovation**

The UN estimates there are over 1bn persons with disabilities worldwide, as well as 2bn people such as spouses, children and caregivers that are directly affected by disability. This group, representing almost a third of the population, can face serious issues when travelling, with inaccessible environments leading to inconveniences or sometimes even embarrassing or humiliating situations.Due to the specificity of each condition, people with special needs require highly detailed information on facilities when travelling. For instance, someone in a regular wheelchair travelling with a companion won’t have any issues in getting over one step. However, someone in a motorised wheelchair travelling alone would face a more serious situation and would probably need to be lifted by untrained staff to get over the hurdle. Existing travel booking systems don’t give users any guarantees on accessibility, with mainstream websites (Booking.com, Airbnb) providing only basic or inaccurate information.With a mission to overcome these limitations, we developed Handiscover, the world’s first inclusive booking system that helps people with a disability to identify accessible accommodation that suits their specific needs and allows them to travel worry-free.Whilst we have a prototype at TRL7, we need to refine, demonstrate and scale up to meet the demand we have seen and to maximise the impact of our solution. Specifically, we need a more automated and wide-ranging system that can account for any form of disability, generate accessibility knowledge amongst hotel staff and better manage hotel accessibility details.By commercialising our solution, we will generate invaluable accessibility data, support the participation into society and in the economy of people with a disability and their fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'P-adic l-functions and iwasawa theory' under Fourth Framework.

assistant: **Concept**

The so-called L-Functions of number fields and of elliptic curves play a central role in number theory; several important conjectures deal with them, for example the main conjecture of Iwasawa theory, and the conjecture of Birch and Swinnerton-Dyer. Recently, a unifying approach to the different kinds of p-adic L-functions has been found, called motivic L-functions. As I used some properties of p-adic L-functions in my doctoral thesis, it is of great interest to me to learn the modern, general theory. There are many open questions in this area, and I hope that I can make some contribution in the Iwasawa theory of elliptic curves.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gene transfer techniques in the treatment of cardiovascular diseases and malignant glioma' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Background: Poor angiogenesis and collateral vessel formation lead to coronary heart disease, claudication, infarctions and amputations while malignant glioma is one of the most aggressive proangiogenic tumors leading to death in a few months. For these diseases either stimulation or blocking, respectively, of angiogenesis may provide novel treatment options. Advancing State-of-the-Art: Our hypothesis is that in ischemia it will be possible to support natural growth of blood vessels with Therapeutic angiogenesis and lymphangiogenesis by using local gene transfer of the new members of vascular endothelial growth factor (VEGF) family and their receptors. New co-receptors, designer mutants and PCR suffling products of VEGFs will be used. New vector technology will be used to achieve long-lasting effects of VEGFs. We aim to develop novel site-specifically integrating, targeted, regulated vectors to precisely express the new VEGFs, their soluble decoy receptors and single-chain therapeutic antibodies (scFv) for pro- and anti-angiogenic purposes. As novel approaches, we have developed metabolically biotinylated lenti- and adenoviruses suitable for targeting and Epigenetherapy where siRNA/miRNAs and short nuclear RNAs regulate endogenous gene expression at the VEGF promoter level via modification of histone code. scFv library for endothelial cells and lentivirus-siRNA library directed to all human and mouse kinases will be screened to identify new mediators of angiogenesis in order to develop next generation pro- and antiangiogenic therapies. Based on our strong track record in Clinical applications, the best new pro- and antiangiogenic approaches will be taken to phase I clinical studies in myocardial ischemia and malignant glioma. Significance: This work should lead to signi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Recovery of Phosphorus from Sewage Sludge and Sewage Sludge Ashes with the thermo-reductive RecoPhos-Process' (RECOPHOS).

assistant: **Innovation**

Natural phosphate sources low in heavy metals are getting scarce. Containing about 15 mass-% of P2O5, sewage sludge ash can be considered a secondary phosphorus (P-) source. The P-content in the European sewage sludge could currently replace roughly 15% of the phosphate imports into the EU.Hence already for many years, almost decades, it has been tried to recover phosphorus from sewage, sludge and ashes in various ways of which none has yet been realised at industrial scale. The reason for this failure lies firstly in the wet chemical approach, meaning complex and little efficient processes with liquids hard to handle; and secondly in the use of liquid or dewatered sludge as well as waste water, which results in a further decrease in efficiency mostly because of high mass flow and matrix effects.The RecoPhos process is a thermal process using ash from sludge mono-incineration. The principle of the used so-called InduCarb process is similar to the one of the known Woehler process; dried sludge can be added as heat source or reducing agent as an option. The phosphate (amongst other constituents) is reduced on an inductively heated coke bed to white phosphorus, which is later condensed and thus separated from other gaseous reaction products; white phosphorous is the most valuable form of phosphorous and highly asked for by the industry. Further products are an iron alloy as well as a heavy metal mixture, both usable in steel industry; a silicate slag for the use in cement ovens as well as a high calorific gas.The RecoPhos process uses an innovative reactor (InduCarb) designed for the reductive recovery of steel work dusts. By the use of ashes the material flow is minimal; if only sludge is available, it can be also used as input, adding flexibility to the concept. If addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Determining optimal approach to deliver malaria vaccine in seasonal transmission areas through Phase 4 implementation research' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Seasonal malaria chemoprevention (SMC), the administration of sulphadoxine-pyrimethamine and amodiaquine (SP+AQ), during the peak period of malaria risk has proved to be a highly effective malaria control measure in areas where transmission of malaria is highly seasonal; SMC was administered to 45 million children in 2021. Still, malaria remains the main cause of hospital admissions among young children in many parts of the Sahel and sub-Sahel and additional control measures are needed to protect children.  The malaria vaccines RTS,S/AS01E, and R21/Matrix, provide a high level of protection during the first few months after a primary series of vaccination, or after a booster dose, but efficacy wanes progressively during the following months and years. Thus, in areas with seasonal malaria transmission, one potential use for these vaccines, which provide a high but relatively short period of protection, is administration of an annual booster dose given prior to the malaria transmission season in children who have received three priming doses of the vaccine in the first year of life. However, there is a debate about the best approach to delivery of the booster doses and the main objectives of this study are to determine whether annual booster doses of RTSS,AS01E vaccine administered pre-transmission season through a mass campaign will achieve better coverage and higher impact on the incidence of malaria than pre-transmission booster doses delivered by an EPI programme at vaccination centres. This will be a pragmatic implementation study involving two cohorts of children. Two districts that have comparable malaria epidemiology, social structure, coverage of EPI vaccines, and access to treatment will be identified in both Mali and in Guinea from the list of districts that ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Novel molecular tools for the analysis of unknown microbial communities ofm ural paintings and their implementation into the conservation/restaurationp ractice'.

assistant: **Innovation**

SUMMARY The partners of this proposal of Research, Development and Application have formed an European team with the following goals: (1) The application of the most advanced tools of molecular biology and biotechnology for an in depth analysis of the environmental risk related microbial communities endangering a set of most sensitive mural paintings in Europe. (2) The detection and determination of hitherto uncultivable or undetected biodeteriorative taxa. (3) To characterize these taxa by all available molecular tools. (4) To develop and apply new in situ hybridisation techniques and Polymerase chain reaction based probes for the material of mural paintings in order to control environmentally induced microbiological hazards and changes in the microflora after conservative treatments with a minimum of or no sampling at all. (5) The mural paintings shall be treated by experienced conservators/restorator after the analysis by the molecular biologists and microbiologists. (6) The treatment success shall be evidenced and documented by the in situ application of the molecular probes and hybridisation techniques developed by the partners. The work will be effected on three different sites with extraordinary mural paintings. The paintings are very damaged and exposed to (1) a very humid and constant internal climate in the case of the Necropolis of Servilia, Spain;  2) humidity rising in the walls of the castle of Herberstein in Austria and (3) to the Sea spray salt endangered Romanesque church of Pilsum in Frisia (Interregio between Holland and Germany) with valuable mural paintings erected 1266 by a Frisian tribal Chief (probably after a pilgrimage to Santiago di Compostela). A genetic data bank of biodeteriorative microorganisms will be established using modern sequencing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimum management system with environment monitoring' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives The project aims to optimize the management system of a plant, such as a cogeneration plant, through environmental monitoring of plant emissions and using an overall approach for component modelling (cost, environment, etc.). During the project, the following will be pursued: a) energy savings through an automatic procedure for optimum load allocation during plant operation; b) reduction of plant pollutant emissions by including, in an off-line model, constraints and environmental costs, established according to data acquired by the environmental monitoring systems. Technical Approach Thermal cogeneration plants are usually equipped with parallel systems; thus, the electric power can be generated by parallel heat engines (diesel engines or gas turbines) and by parallel steam turbines. The plant will be modelled through a set of software codes taking into account mechanical (University of Rome, Fachhochschule Schmalkalden), cost (University of Ulster) and environmental (National Technical University of Athens) aspects of the plant components. These software codes will improve operation efficiency by computing the suitable loads for the various equipment, taking into account actual conditions, emissions and economic aspects. The relevant information will be exchanged through a common database, while the control software code will be implemented by logic programming techniques (Cap Gemini). The cogeneration plants at FIAT and HAR will provide the necessary data for two case studies. ENEA will prepare the validation set-up at the two plants before and after running the model. Expected Achievements and Exploitation The expected achievements are as follows: - a fast and reliable automatic method for finding optimum set point maps; - updated component behaviour by u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spinning in the Era of the Spinning Wheel 1400-1800' (SESW).

assistant: **Innovation**

From the introduction of the spinning wheel to England during the later Middle Ages to its eclipse by the powered spinning machine early in the nineteenth century, hand-spun yarn was vital to the success of the textile industries that dominated English manufacturing. Indeed, hand spinning of wool, flax and ultimately cotton became the principal income-generating activity pursued by women. For many of those women, it was also an essential means of furnishing their own families with textiles. Yet the history of spinning in the period has never been the subject of a major study in its own right. Spinning in the Era of the Spinning Wheel aims to rectify this anomaly. Its objective is to provide a comprehensive history of hand spinning in England between 1400 and 1800 that approaches the subject from the whole range of relevant perspectives, treating it as a practice that was at one and the same time material, technological, economic, commercial, legal, cultural, gendered, and global. This will involve an approach that is multi-disciplinary, embracing historical, literary, legal, technological and scientific approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanism of protease inhibition in the protection of lungs against emphysema' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives:The lungs are protected against enzymic damage by protease inhibitors, and principally by a1-antitrypsin. The overwhelming of these inhibitors as occurs in the genetic deficiency of a1-antitrypsin, gives cumulative destruction of lung elasticity with eventual development of emphysema. In order to pursue strategies for the prevention of this progression we need to understand the precise mechanism of protease inhibition. We now know the structure of a1-antitrypsin and can confidently deduce how the protease and inhibitor initially interact but the key step, the formation of the final irreversible complex, is still a matter of conjecture.To determine the precise molecular mechanism involved we plan a combination of: 1) a crystallographic approach to give the structural relationships in the complex,2) an NMR approach to show the bonding mechanism involved.The lungs are protected against enzymic damage by protease inhibitors, and principally by alpha-1-antitrypsin. The overwhelming of these inhibitors as occurs in the genetic deficiency of alpha-1-antitrypsin, gives cumulative destruction of lung elasticity with eventual development of emphysema. In order to pursue strategies for the prevention of this progression we need to understand the precise mechanism of protease inhibition. We now know the structure of alpha 1-antitrypsin and can confidently deduce how the protease and inhibitor initially interact but the key step, the formation of the final irreversible complex, is still a matter of conjecture.To determine the precise molecular mechanism involved we plan a combinationof:1) a crystallographic approach to give the structural relationships in the complex;2) an NMR approach to show the bonding mechanism involved.To achieve this a series of recombinants of alph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Digital Resonant Laser Printing for Mass Customization of Flat Optics' to be submitted under Horizon 2020.

assistant: **Abstract**

Flat optics is used in everyday, compact devices like mobile phones and other portable devices, where size and weight is important. DeLight will transform the holographic resonant nano-scale laser printing of flat optics using template dielectric meta-surfaces, developed by DTU in FET OPEN CHROMAVISION, into a commercially attractive and sustainable business and a University spin-off. The DeLight ultra-high resolution laser printing technology enables mass-customization of flat-optics, with a wide application field, such as opthalmic lenses, advanced optical filters, and optical sensor technology for the Internet of Things (IoT). DTU has filed three international patent applications on the technology and published the research results in high impact journals (Nature Nanotechnology, Science Advances, Nature Reviews Materials). At present, the technology is  at TRL4. The technology is demonstrated in the lab. The main project activity will be: 1) Develop a business case, 2) Identify the market segments and needs, 3) asses technology with end-users and 4) initiate a University spin-off.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High-resolution, all-digital microscope that applies computational methods to bring revolutionary benefits of digital microscopy to small and medium sized laboratories' (SCOPIO), addressing dissemination and exploitation.

assistant: **Impact**

Scopio Labs aims to expand the use of Whole Slide Imaging (WSI) for its application in digital pathology and is developing a digital microscopy platform capable of scanning high resolution images with low hardware costs.Despite digital microscopy exists for decades, its use has been limited by the high prices of the technology. Our solution provides a low cost-high quality technology which will allow the implementation of WSI facilities in small hospitals and diagnostic centres. By using cutting edge principles of computational photography, we are able to enhance resolution and magnification (up to 100X) of images taken by affordable optics and mechanics through a disruptive computation method.Biopsies are frequently used to determine different diseases as psoriasis, diabetes, hepatic diseases, infections or cancer. Every year, more than 3 million new cancers are diagnosed and cancer is causing around 1.7 million deaths worldwide. Its early diagnosis has been pointed out as a factor for increasing patient survival. Our technology upgrades the diagnosis process with substantial time savings and connects and assists pathologists and experts worldwide with its analysis software.We estimate the total addressable market for WSI, including the sale of hardware, software and services enabled by the digitization of glass slides, to grow from $1.3B/year to $11B/year in the next decade. We forecast that during the next five years after commercialization, we will have sold about 3,150 digital microscopes and hired 38 new employees. We will earn almost €58M profit with a ROI of 6.47. Payback will be reached already in 2021.