RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Solar Twinning to Create Solar Research Twins' to be submitted under Horizon 2020.

assistant: **Abstract**

Research and Innovation (R&I) in Concentrating Solar Thermal (CST) technologies promises global impacts through new and sustainable solutions to societal challenges. CST technologies include 1) Solar Thermal Electricity (STE/CSP), 2) Solar Heat for Industrial Processes (SHIP), 3) Solar Fuels, and 4) Clean and Fresh Water. Europe is currently a global technology leader in CST, and SolarTwins is designed to strengthen this leadership position. The Goal of SolarTwins is to Step-Up the Scientific Excellence and Innovation Capacity of the Promising Institution METU-GÜNAM's CST research laboratory through Twinning with the Leading Institutions PSA-CIEMAT and DLR. SolarTwins builds on several EU CST R&I networks and activities in which all 3 institutions are participating including EU-SOLARIS, EERA-JP-CSP, and SFERA-III. SolarTwins contains 3 Twinning Work Packages (WPs 1-3). WP1 contains cross-cutting activities including Joint Kick-Off Activities targeting stakeholders and External Training to strengthen local, regional and national R&I capacities. WP2 is dedicated to ESRs and contains 2 summer schools at METU taught be experts from PSA-CIEMAT and DLR, and exchange of METU ESRs to PSA-CIEMAT and DLR for training and research mentoring. WP3 is dedicated to developing joint research lines between METU-GÜNAM and each of PSA-CIEMAT and DLR. WP3 includes activities for METU-GÜNAM personnel at each of PSA-CIEMAT and DLR to formulate joint research lines, and METU-GÜNAM staff exchange to each of PSA-CIEMAT and DLR to develop joint research proposals. WP4 is dedicated to maximising the Impacts of SolarTwins and includes Exploitation, Dissemination, and Communication tasks, and a Final Conference. WP5 is dedicated to project management. SolarTwins is specifically formulated to lead t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Muscle Specific C. elegans Genome in health and disease: finding novel factors in 3D organization' (2014-2020).

assistant: **Concept**

The loss of structural integrity in the interphase nucleus leads to tissue-specific pathologies in a set of human diseases collectively called laminopathies. These are late-onset, tissue-specific degenerative diseases, such as Emery Dreifuss Muscular Dystrophy (EDMD). While rare, these conditions provide insight into more common degenerative disorders linked to aging. A Caennorhabditis elegans mutant that recreates the EDMD phenotypes arises from introduction of a specific gain-of-function mutation into lamin (LMN-1 Y59C), which in turn affects the subnuclear distribution of muscle-specific promoters. This proposal plans to identify novel factors that establish and/or maintain the 3D organization of the genome in differentiated nuclei and to determine how this contributes to the differentiated muscle cell fate. I propose that compromised or altered sequestration of chromatin at the nuclear envelope alters cell-type specific promoter induction and in turn compromises the integrity of the tissue in question. The specific aims of the project are 1) To identify factors that establish and/or maintain 3D genome organization in muscle nuclei. 2) To determine if the integrity of the perinuclear chromatin binding machinery helps maintain differentiated cell states. 3) To test inhibitors of epigenetic regulators for compounds that overcome the EDMD-like LMN-1 Y59C mutation. I will take two complementary approaches to determine how muscle specific chromatin organization maintains tissue integrity. I will use in vivo biochemical tagging in the LMN-1 Y59C mutant to identify perinuclear components that mediate sequestration of muscle-specific gene promoters. In parallel, a drug screen will find compounds that reverse the nuclear disorganization linked to the EDMD-like phenotype. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cavitation-based bio-ablation and drug delivery' (CAVIAR) targeting Horizon Europe.

assistant: **Abstract**

The proposed research will critically advance the medical use of high-intensity focused sound waves, namely ultrasound and shock waves. In particular, the project aims to break grounds by elucidating the physics behind ultrasound and microbubble-mediated targeted drug delivery and non-thermal, cavitation-based ablation of biological tissues and stones, relevant in the treatments of neurological diseases, tumours, blood clots, bacterial infections and kidney stones. Through carefully designed in-vitro experiments, the project aims at explaining and comprehensively characterising, uniquely within a single framework, the currently elusive mechanisms behind the mechanical bioeffects produced by cavitation activity across a wide range of acoustic driving conditions from gentle, low-amplitude ultrasound for reversible cellular sonopermeabilisation to drugs up to the fragmentation of stones in shock wave lithotripsy. This will be achieved using a unique combination of advanced measurement techniques such as ultrafast videomicroscopy and synchrotron X-ray imaging, and leveraging the PI's expertise in acoustics, microbubble technology and the physics of cavitation.The expected outcomes of the proposed research are to i) help optimise the mechanical effects in medical sound wave therapies to improve their safety, precision and efficacy and allowing swift clinical translation for emerging medical therapies; ii) significantly advance experimental techniques to spatiotemporally resolve ultrafast microevents; iii) refine acoustic cavitation detection techniques in the clinical setting by correlating specific visually observed cavitation activities to their acoustic signatures; and iv) propose a new, rigorous measure to assess safety against mechanical bioeffects caused by cavitation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling Anaerobic Digestion using Single cell and Long Read Sequencing' (UnrAD).

assistant: **Innovation**

Anaerobic digestion, a technology able to use waste residuals to produce clean renewable energy in form of methane, is a powerful tool to revert the unequivocal environmental deterioration and represent one of the clearest examples of how research and innovation can turn undesirable residual like waste into an ecological and economical asset. Recent advances made feasible the process at ambient temperature, feasibility that might increase the net production since does not need heat supplementation. Among the different trace metals involved in the anaerobic degradation processes, cobalt has been shown one of the most important since it acts as a cofactor for enzymes involved in the metabolic pathways of the methanogenesis from acetate. Therefore an adequate balance of cobalt could improve the anaerobic biological response, enhancing the rate and yield of methane. High throughput single-cell transcriptomic and third generation sequencing provide an unprecedented opportunity to understand the mechanisms inducing this enhanced yield. The first allows trancriptome analysis at the level of individual cells giving the possibility to understand the interplay of transcripts within single organisms, the specialization of different members from the community or the heterogeneity in term of transcriptomic status of every species while the second enable the possibility recover full length transcripts increasing resolution. The overall objective of UnrAD is to employ these two cutting-edge technologies combined to study the role of temperature and cobalt supplementation in anaerobic digestion and identify specializations and interactions among the different bacterial community members. The findings from this project would lead to a more efficient anaerobic digestion and will be benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Contamination of food with biological agents: An integrated risk analysis and risk communication approach' (2007-2013) under Seventh Framework.

assistant: **Objectives**

In spite of efforts to improve safety throughout the food chain, globalization of the food trade presents new challenges to assure food safety. Any contamination that occurs in one country may have severe consequences on both health and trade in other countries. Moreover, the events of September 11, 2001 and the subsequent anthrax incidents gave rise to concerns about food terrorism. The destructive impact of food contamination, intentional or unintentional, could easily affect an enormous amount of people and could result in high costs for the world’s economy. Besides its effects on health and economy, deliberate or accidental food contamination may have social implications such as social and political instability. Contamination of food from biological agents is a focus of concern across various disciplines within the risk analysis field. Natural scientists are mainly concerned about risk assessment, whereas social scientists are focused on risk perception and risk communication. The integration between these two disciplines is quite limited, whereas effective campaigns would require collaboration between natural and social sciences, the former to ensure that the advice is technically sound, the latter to ensure that is accepted and executed (Fischer et al., 2005). Fischhoff et al. (2006) have pursued such an integrated strategy in many other domains, using risk analysis models to focus and coordinate the relevant behavioral and natural sciences. The proposed project would strengthen the behavioral realism of this integrated approach and apply it to the possibility of deliberate or accidental food contamination with a biological agent. Specifically, the expertise of natural and social science experts will be combined and used to communicate with European consumers abou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting the Functional Role of Mucosal IgA Clonal and Glycoprofiles for Effective Humoral Mucosal Protection' under Horizon Europe.

assistant: **Concept**

Numerous mucosal vaccines and IgA-based monoclonal antibodies aimed at a robust immunity within the respiratory tract are in development to combat viral endemics and pandemics. However, investigations into humoral immunity have predominantly focused on circulating antibodies, particularly those of the IgG isotype. This has left a significant void in our understanding of the role of mucosal IgA proteoforms in conveying effective immune protection. This crucial knowledge gap deprives vaccine and antibody development of crucial determinants or immune characteristics to replicate.In response to this, we will conduct in-depth investigations of mucosal IgA including in vitro and in vivo functional evaluations. We will capitalize on recent advances in liquid chromatography and mass spectrometry-based approaches for the detailed characterization of mucosal IgA clonal repertoires and glycosylation profiles, a field that has remained completely unexplored until now, B-cell receptor sequencing, monoclonal IgA glycoengineering and in vitro functional assays. We will take advantage of our unparalleled biobank of human nasal secretion samples with clear documentations of infection outcomes on an individual level. What sets our approach apart is thereby the unprecedented molecular-level characterization of IgA, directly linked to their in vitro functionality and pre-defined clinical outcomes, which clearly surpasses current state-of-the-art.By harnessing our in-depth characterization of mucosal IgA coupled to functional traits, we will generate IgA templates with enhanced binding and neutralization capabilities as well as functionally advantageous Fc effector potencies. Our overarching aim is to provide molecular-level blueprints for protective monoclonal IgA-antibodies, enabling the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthetic routes to useful phosphorus compounds' in the context of a Sixth Framework call.

assistant: **Objectives**

This project focuses on the transfer and integration of distinct but highly complementary areas of research competence in an SME and an academic Institute. The Academic hosts expertise lies in the area of organolithium/sparteine chemistry. The Industry partners expertise lies in the area of the development of homogeneous catalytic routes to chiral molecules, which can lead to significant manufacturing cost-reductions e.g. in pharmaceutical manufacturing processes. The aim is to build a long-term strategic partnership: for the SME its core discovery platform can be enhanced greatly to increase its competitiveness, whereas the academic host will also learn from the industry partner how to work in a commercial environment. In this project, 2 scientists from the SME (one of whom will be newly recruited from across Europe with special attention given to New Member States), will work in the University to acquire specific expertise and know-how on organolithium/sparteine chemistry. In parallel, the seconded scientists will impart their industrial expertise, project management skills and commercial working experience to the academic host. There will also be the opportunity for them to transfer some specific High Throughput Experimentation (HTE) expertise to the University. After this secondment they will return to integrate the acquired knowledge back to the company. In order to enhance a mutual knowledge transfer, the Academic host group leader will work at the SME, especially near the end of the project, to ensure that the knowledge acquired by the 2 scientists will be successfully integrated into the company setting. The project addresses various major strategic objectives of the European Commission - most notably the empowerment of world-class research and development in SM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards a safe, reliable and cost competitive transport sector in Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Heavy Transport Industry is subject to intense pressure both from fierce competition and from increasing fuel costs and stringent regulations on air pollution, traffic management and carbon emissions. At the same time the industry is relying more and more on truck and bus batteries to crank and start engines as well as to run an increasing number of electrical loads. This stress imposed on batteries is one of the major causes of engine start failure with consequent delays on delivery and additional maintenance costs.C2C was founded in 2014 to solve this problem by bringing a new Electric Double Layer Capacitor (supercapacitor) to the energy storage market, the C2C-NewCap.This technology holds a large range of applications from Heavy Truck engine cranking and hybrid traction passenger vehicles to wind turbine pitch control or even utility grid peak shaving.After the initial 200K€ research project started in 2011 funded by public sources, we have raised 210K€ through Venture Capital from Caixa Capital and Innoenergy. This investment allowed us to develop our technology from the lab scale to demonstration in real application conditions (TRL6).In what concerns heavy trucks and buses we eliminate the dead-battery risks by dedicating the starting function to our supercapacitors. We have chosen transportation as our entry market due to the big need existing in the heavy transport segment, where we have a perfect fit, relevant industrial partners and few competitors from whom we differ with a patented technology that makes ours simpler to install, safer to operate, more eco-friendly, more reliable and cheaper.The successful market application of the C2C-NewCap technology will mean more on-time deliveries, less fuel consumption, carbon emissions and air pollution and, ultima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ECOLORO: Reuse of Waste Water from the Textile Industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Constant extraction of increasingly scarce fresh water puts a vital demand on increasing water-use efficiency in all sectors. The ECWRTI project will demonstrate the EColoRO concept on full industrial scale in two locations in the European textile industry. The EColoRO concept uses electro-coagulation (EC) combined with flotation to remove pollutants, colorants and chemicals from waste water very effectively.  This unique feature enables using ultrafiltration and reverse osmosis membrane processes downstream in an optimized way. The key advantages are: - Total reuse of waste-water in textile industry reducing fresh-water intake by at least  75% - Low-cost and economically highly attractive - Very flexible, containerized and modular, easy scalable, low footprint, suitable for retro-fit, brownfield or greenfield application- Low energy use, no use of chemicals or flocculants, producing concentrated waste streams with very high re-use potential- Enabler for optimizing use of water, allowing for advanced energy and resource efficiency in the textile manufacturing processesEC and the EColoRO concept are currently proven at TRL 6. The ECWRTI project will run for 48 months and will deliver technological proof at TRL 8, ready for commercial uptake. It will further deliver the materials, analysis and tools needed for rapid commercial roll-out.The consortium consists of a focused and well-balanced team. The project is SME driven with EColoRO as coordinator and 6 partners from 3 EU member states with key know-how on waste water purification (VITO, EColoRO), textile technology and production (Inotex, Utexbel, Tintoria Pavese), electro-coagulation and engineering (Morselt),  process technology, open innovation and project support (ISPT) and EU wide market access in the textile secto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chasing pre-industrial aerosols' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Aerosol particles affect the climate by scattering incoming radiation and by acting as cloud condensation nuclei; however, their net effect remains of highest uncertainty, specifically when quantifying their relationship to anthropogenic greenhouse gases. It has been estimated that 45% of the variance of aerosol forcing arises from uncertainties in natural emissions. This highlight the importance of understanding pristine preindustrial-like environments, with natural aerosols only. One of the great challenges in understanding preindustrial aerosols and their sources resides in identifying the processes by which new particles form and grow from oxidized vapours.We recently presented in Science the ground-breaking observation of purely organic nucleation. The existence of this mechanism was confirmed by laboratory experiments where we show that highly oxygenated molecules are able to form new particles independent of H2SO4. This finding sheds the light into the preindustrial era where the anthropogenic emissions were almost absent and H2SO4 concentration was rather minimal.The aim of my project is to provide unprecedented data to resolve the preindustrial nucleation mechanism. I will organize intensive long-term measurements in pristine preindustrial-like environments like the Arctic and Siberia. Using state-of-the-art chemical ionization mass spectrometry, I will retrieve the chemical cluster composition and the vapours concentration. Additionally, I am planning short intensive measurements at high altitude above the oceans. Finally, these measurements will be complemented by laboratory experiments needed to probe the observed mechanism and retrieve a parametrization that can be used in global modelling.The outcome of these field campaigns combined with laboratory experi