RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EPIGENETIC REGULATION OF INFLAMMATION IN NAFLD' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing clinical problem, affecting a third of the European population. The transition of hepatic fat accumulation to inflammation is the key event taking place in the progression of NAFLD. This is controlled by a number of inflammatory and immune pathways including the activity of Natural Killer (NK) and Natural Killer T (NKT) cells. Progression from hepatic lipid deposition to inflammation and cirrhosis also follows a substantially variable course. It has been estimated that less than 10% of patients develop end-stage liver disease. Individual variability for disease progression is partly controlled by environmental factors and genetic background. However, it is not known how immune and inflammatory pathways are orchestrated by epigenetic mechanisms. The project hypothesises that “NK and NKT cells are programmed into inflammatory state by epigenetic modifications in progression from fatty liver to inflammation”. In this project, histone modifications and DNA methylation will be studied by genome-wide and loci-specific approaches in NK and NKT cells purified from animal models of NAFLD and a prospectively-designed human NAFLD cohort. Reversibility of these modifications will be investigated following the regression of liver disease in animal models and after the implementation of lifestyle changes in humans. Lastly, the therapeutic potential of targeting histone modifying enzymes by short hairpin RNA and small molecule inhibitors in NK and NKT cells for modulating inflammatory response will be investigated. The project will be the first comprehensive study investigating cross-talking epigenetic mechanisms in NK and NKT cells in NAFLD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Heavy quark physics in non-relativistic lattice qcd', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

We propose a quantitative ab initio study of new particles containing heavy b and c quarks to provide predictions, for experimental searches at CERN and DESY. We will use new techniques being developed at Glasgow for non-relativistic systems in Quantum Chromodynamics (QCD), together with supercomputer lattice simulations. Combining nonrelativistic b quark propagators from Glasgow code with relativistic c quark propagators from the UKQCD collaboration, will give most accurate results to date. Calculations will include: the excitation spectrum of the Bc system, its decay constant, the form factor of the semi leptonic decay to the charmonium system and the spectrum of exotic hybrid mesons containing heavy quarks and gluonic excitations. Besides further education in theoretical and experimental aspects of heavy quark physics, this project provides training in the techniques of non-relativistic lattice QCD and the sophisticated multi-exponential fitting routines which reduce systematic errors in lattice results. Training in the programming of MIMD parallel supercomputers (e.g. CRAY T3D, J90) is also provided. This will enable a future independent research programme in the burgeoning area of heavy quark physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ligninolytic Enzymes: Keys to unlock the hidden potential of lignin' (LIGNIN-IB-PEROXIDASE) under Horizon Europe.

assistant: **Objectives**

Context: Globally, 50-70 million tons of lignin, a highly branched heteroaromatic polymer, are discharged per year as a waste material from the paper and pulp industry despite being touted as the most abundant renewable source of different value-added products on earth. Leaving 98% of lignin underutilized, industries degrade only 2% of lignin and that also comes with environmentally hazardous thermochemical processes.Background: Recently, the discovery of heme-containing class II fungal peroxidases viz. lignin peroxidase (LiP), manganese peroxidase (MnP), versatile peroxidase (VP), dye-decolorizing peroxidase (DyP) garnered a lot of attention due to their biodegradable ligninolysis. However, the industrial application of peroxidase-based lignin degradation still seems to be a far-flung dream owing to low availability of peroxidases in sufficient amount, enzyme instability in industrial effluent, high enzyme cost and long process times.Aims and objective: I hypothesize that a cocktail of engineered stress tolerant, active and stable peroxidases could lead to synergistic biodegradation of lignin. To achieve this, artificial intelligence (AI) tailored LiP, MnP, VP and DyP will be cloned and expressed as inclusion bodies (IBs) in E. coli using Prof. Spadiut’s expertise whereas mine will employ solubilization and refolding strategies to increase the overall yield of bioactive protein. An ideal stoichiometric combination of engineered peroxidases will be standardized to withstand the harsh conditions of industrial effluent, resulting in a sustainable and economic ligninolytic technology.Concluding remarks: The project is inspired from nature, backed with AI and stemmed with the expertise of mine and Prof. Spadiut’s in producing recombinant bioactive protein from bacterial IBs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cultural Heritage Knowledge Exchange Platform' under Seventh Framework.

assistant: **Concept**

The general objective of the SMARTMUSEUM project is to develop a platform for innovative IT services enhancing on-site personalised access to digital content of cultural heritage through adaptive and privacy preserving user profiling. Using on-site distributed knowledge databases, global digital libraries, and visitors' experiential knowledge the platform makes possible creation of innovative multilingual IT services for increasing interaction between visitors and cultural heritage objects in future smart museum environment, and taking full benefit of the digitalized cultural information.<br/><br/>SMARTMUSEUM project supports achievement of following general goals:<br/> * Lowering costs of on-site access to digital cultural heritage content<br/> * Improving structured, user behaviour and preference dependent on-site access to cultural heritage<br/> * Improving the meaning, individual and shared experiences people receive from cultural and scientific resources<br/> * Bringing personalized cultural experience closer to non-expert community<br/> * Making real reuse of personal experiences related with cultural heritage access for variety of interest groups<br/><br/>In order for developing SMARTMUSEUM platform following sub-goals are set:<br/> * Developing cultural heritage (CH) related metadata extensions to represent user preferences<br/> * Creating internal standard for representing user cultural interest preferences in a form of formal profile. <br/> * Creating privacy preserving adaptive user profile management for PDAs and web services <br/> * Creating of services (dedicated search engine) capable of digital content mining and indexing for variety of user profiles.<br/> *Creating easy search solutions for local and global reuse of cultural heritage related knowledge (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterisation of the structure of the early oligomeric aggregates on the amyloidogenic pathway of lysozyme' (AMYLBODY) targeting Sixth Framework.

assistant: **Abstract**

Aberrant folding and aggregation of soluble proteins into amyloid-like deposits has been associated to more than 20 known human disorders, including Alzheimer's disease, spongiform encephalopathies and type II diabetes. Recent research has indicated that the early oligomers present prior to amyloid fibril formation represent the most dangerous species to the cell and that their specific conformational properties determine their toxicity. It has been therefore realised that the structural characterization of these oligomers represents a crucial step in the development of treatments for diseases associated with abnormal protein aggregation.This objective, however, presents formidable challenges, due to the transient lifetime and the heterogeneous nature of such oligomeric species. In this fellowship application we propose to exploit the ability of specific antibodies to bind the early oligomeric aggregates of lysozyme in order to characterise structurally the initial steps of its amyoidogenic pathways. The camel single domain antibody, cAb-HUL5, significantly inhibits fibril formation in lysozyme by stabilising dimers or early oligomers, thus effectively preventing them from being incorporated into higher order oligomers and fibrils. These antibody-bound dimers will be characterised by advanced NMR methods and the structural information acquired in this way will subsequently be used in structure calculations.We will thus be able to obtain for the first time an ensemble of structures representing the conformations populated by the antibody-bound dimeric state of lysozyme. The results of this project will clarify important fundamental aspects of the early stages of the processes of fibril formation and aggregation of proteins, and offer a basis for the development of therap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Certified Disinfection of workwear garments for the food industry' under Fourth Framework.

assistant: **Concept**

Recent litigation in the US industrial laundry market and tageted at the cleaning of workwear for the food industry, has created a rapidly expanding market for high technology laundry systems that can guarantee the level of garment disinfection. this project applies advanced technology research into standards, disinfection and traceability in laundry systems for clean environments. It provides the means for the EU SME industry to maintain its lead in high technology laundry systems, in response to the threat from the US industry which is now switching from low cost, low technology systems and is becoming more competitive throught the use of technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Cardiovascular Health effects of Air pollution in Andhra Pradesh, India'.

assistant: **Innovation**

While there is convincing evidence that exposure to particulate air pollution causes cardiovascular mortality and morbidity, nearly all of this evidence is based on populations in high-income countries where concentrations are relatively low. There is large uncertainty regarding the relationship between combustion particles and cardiovascular risk for concentrations higher than outdoor concentrations in urban areas of high-income countries and lower than active smoking.  Exposures for our study population are likely to be in this range.We will investigate the cardiovascular health effects of exposure to particles from outdoor and household sources within a prospective cohort in Andhra Pradesh, India. Firstly, we will characterise exposure of participants using an integrated approach utilising outdoor mobile monitoring, personal monitoring, and questionnaire data. We will then collect data on participants’ activities and location using ‘life-logging’ from which activities driving exposure can be identified. Finally, we will quantify the association between exposure to particles and biomarkers of atherosclerosis.This research will shed light on the relationship between particles and cardiovascular risk at concentration ranges where there is the largest uncertainty. It will provide some of the first evidence of the cardiovascular health effects of medium-term exposure to particulate air pollution outside of a high-income country. The research will also provide evidence regarding the relative contribution of sources and activities linked to high exposure, forming the basis of recommendations for exposure reduction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Common molecular pathways in progression of kidney disease'.

assistant: **Objectives**

Throughout Europe and over the world millions of people are affected by chronic renal failure leading to immense human suffering and an increasing economic burden. Research in recent years has indicated a common pathway responsible for progressive renal injury and end stage renal failure. Partial insight has been achieved in the role of a few molecules that represent snapshots in time of the complex, largely unknown regulatory pathways. In the concerted action on renal fibrosis and scarring (BMH4-CT98-3631) we have established a unique tissue bank of precious renal biopsies of patients with the most common causes of renal disease from expert centres of the European Union. It is the purpose of the present project to delineate the common molecular pathways of renal injury using state of the art genomics and protenomics approaches and design diagnostic tools to predict progression and prevent end stage renal failure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Diet and cancer: the explanatory value of dietary patterns' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

TECHNOLOGICAL PROBLEMEvidence shows that most of the presumably diet-related cancers are not caused (or inhibited) by a single nutrient or food. In order to obtain more insight into the relation between diet and cancer, this study aims to examine the explanatory value of dietary patterns. Dietary patterns reflect the naturally prevailing combinations of nutrients and foods in the free-living population. This study will develop and apply a common methodological approach to examine the relation between dietary patterns and cancer in four European countries, ranging from Finland to Italy. This cross-cultural approach will provide more insight into the validity and generalizability of the dietary patterns, and into the patterns and/or risk factors that consistently enhance or protect against cancer across different countries. This project may contribute significantly to the knowledge on the factors that cause or incite cancer.EXPECTED RESULTSThis Concerted Action will give insight into the prevailing dietary patterns in each of the participating countries and into the validity and generalizability of the patterns across the countries. Moreover, by linking the dietary patterns found to the risk of several types of cancer in each study, insight will be gained into the patterns and/or risk factors that consistently enhance or protect against these cancers across the different countries. APPLICATIONSAs dietary patterns are closer to behaviours that can be modified than nutrient intakes, studies on dietary patterns are more constructive for the design of successful nutrition intervention programs. If this project shows that the association between dietary patterns and cancer appears to be universal, dietary patterns are valuable for the development of health promotion activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A European Consortium for Lysosomal Disorders', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The EUCLYD consortium aims at developing a scientific network among outstanding communities of basic and clinical investigators in five European countries (Italy, Netherlands, UK, Sweden and Germany) to study various aspects of lysosomal storage diseases (LSD). LSDs are rare disorders (overall prevalence of 1/5000 to 1/8000), each due to a specific lysosomal enzyme deficiency, leading to intracellular storage of a variety of undegraded substrates (sphingolipids, glycosaminoglycans, glycoproteins and glycogen) in different tissues. Among the 40 to 50 LSDs presently known, EUCLYD will focus on Gaucher disease, Pompe disease, MPS VI and Multiple sulfatase deficiency, as prototypes of disorders with different stored materials in various organs and tissues outside the CNS. The issues to be investigated in the proposed project are: pathophysiology and mechanisms underlying the symptoms and leading to devastating clinical consequences; natural history; testing of novel therapeutic approaches. These issues will be addressed by patients studies and with mouse models recapitulating the phenotype of LSDs.  Recent advances in the pathophysiology of LSDs point to the role of secondary processes triggered by substrate storage. A better understanding of these processes is crucial to identify new targets of therapy. Enzyme replacement and substrate reduction therapies were successfully introduced in the treatment of specific LSDs. However, pilot clinical trials should be supported by post-marketing studies to further assess the efficacy of these therapies and to develop standardized treatment protocols. To this purpose a precise knowledge of the natural history of LSDs is essential. Novel therapeutic strategies, such as enzyme enhancement and gene therapy are still under investigation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Definition, analysis and interpretation of a new typology of the Roman House: The Tetrastyle Courtyard House, a domus with a hybrid cultural conception sheltered by a global civilization of Antiquity'.

assistant: **Objectives**

In the recent decades, some studies have found a particular typology of Roman house in different parts of the Empire. This typological feature is the result of a hybrid house scheme be-tween the Greek and Roman conceptions of the house. The new typology has been observed in different Roman cities with a Greek past, but in different geographical contexts and chronologies. This type of home, with its variants, has not been enough analysed by the Roman domestic architecture studies. There are still many Roman cities with a Greek past which private architecture has not been thoroughly studied. The study of a domestic unit enable us to approach issues vital to understand the private sphere of ancient societies, such as the relationship between the individual and the society, the family and the state, production and consumption or macroeconomics and microeconomics. It is therefore necessary to establish and document accuracy the various households that existed in antiquity to better understand the first stage of any cultural society. In this case a house that has a cultural exchange for the formation of its scheme and its role in the society in which it has been developed. The Tetrastylon Project is designed to create the scientific basis for the identification and definition of the new type of Roman domus: ""The tetrastyle courtyard house"". Conducting Tetrastylon will significantly contribute to analyse 1) the European cultural heritage and identity, 2) the diversity of the European culture and 3) the interaction and translation of traditions of its different countries and regions. All of them are research goals recommended by the Horizon 2020 Framework Programme.""