RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Keeping gene expression in check: eliciting the role of transcription in the maintenance of genome integrity.' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Genomic integrity is essential for accurate gene expression and epigenetic inheritance. On the other hand, a prolonged transcriptional arrest can challenge genome stability, contributing to genetic and epigenetic defects and the mechanisms of ageing and disease.Here we aim to identify the molecular mechanisms that couple transcriptional arrest to chromatin alteration and repair. We wish to explore the idea that transcription suppresses cellular toxicity and preserves genetic and epigenetic inheritance.Towards these goals our work will be focused on:1. Deciphering the molecular events impinging on the manner cells respond when the progress of a transcribing RNA polymerase II is blocked.2. Exploring a novel, so far unanticipated function of key players of the transcription-associated repair pathways, such as the Cockayne Syndrome (CS) proteins, not related to repair.3. Understanding the role of transcription in chemotherapeutic-driven toxicity.4. Investigating novel post-translational modifications of CS and determining their function.These objectives will be addressed using advanced proteomics and genome wide technologies in combination with biochemical and cellular techniques in normal human cells and a large battery of patient-derived cell lines. Our rational is that better understanding of CS function will help reach our ultimate goal, which is to identify the regulatory cascades involved in the interplay between genomic stability and transcription. The novel key idea put forward in this proposal is that active transcription itself directly contributes to genome integrity. While the role of DNA damage-driven transcription blockage in promoting repair is well established, the protective role of active transcription in genome stability is entirely unexplored.If successf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artefacts and methods to establish traceability of large coordination measuring machines - cmms' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Large Coordinate Measuring Machines (CMMs) are mainly used for process control and quality-inspection of manufactured parts in industrial production (e.g.automotive, machine tool, aircraft, and spacecraft industry). The correctness and reliability of CMMs which are the ultimate reference in manufacturing processes must be guaranteed because it is essential for the safety and the quality of the manufactured products as well as it is for the cost-effectiveness of these manufacturing processes (Rejections and non-conformities due to dimensional inaccuracies are estimated to be about 8% in automobile industry). The full calibration of any CMM requires the development and assessment of three tools: calibration pattern, machine parametric error correction software and associated calibration procedures. Currently, no industrially recognised method exists for large CMMs calibration; consequently, each company has to develop its own approximated calibration methods, normally based in the extrapolation of the procedures used for smallmedium sized CMMs. Associated procedures and tools are not sufficiently developed nor have been thoroughly tested; its industrial applicability is currently accepted due to the inexistance of more reliable alternatives. The collaboration between industrial companies an Research Organisations in the Consortium, fosters the development of new calibration techniques, based in rigorous scientifical approach, but also in the cost-effectiveness principles demanded by industrialists. Project goal is to develop reference objects, calibration procedures, and parametric error correction softwares suited to the specific metrology industry needs: this means reliable, easy to use and fast to handle tools to assess the errors in large CMMs. Probability of the resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COral Surface MICrolayer: production and dynamics of mucus-associated microbial communities' (COSMIC) targeting Seventh Framework.

assistant: **Abstract**

Microbial biofilms that flourish within mucous sheets play decisive roles on the microspatial to the ecosystem scale. Coral surface mucus forms a dynamic boundary layer between the coral host epithelium and the surrounding seawater. Coral mucus sustains a diverse microbial assemblage and acts as a first barrier of defence against a wide range of environmental disturbances, thereby contributing to the health of the coral holobiont. Surprisingly, only little is known about the physical and chemical properties of this mucus layer, its dynamics of production and maintenance. Particularly, the relation between mucus layer dynamics and the diversity, abundance and function of its resident and visitor microbes remains largely enigmatic. The main goal of COSMIC is to understand the dynamics of composition, secretion and release of coral surface mucus and the related changes on the development, structure and potential function of its associated microbial community. COSMIC will apply a multidisciplinary approach that combines measurements of thickness, organic matter, carbohydrate and lipid composition of coral mucus, with molecular phylogenetic analysis, metagenomic profiling and quantification of major domains of the coral mucus microbiome. Overall, the proposed project will elucidate on key topics such as host and microbial specificity, microbial niche diversification, mucus selectivity, microbial succession and the role of microbes on biogeochemical cycles in corals and in the coral reef ecosystem. Such study on the dynamics of coral surface mucus layer and its associated microbial communities can contribute to understand and predict impacts on coral reefs arising from a rapidly changing climate. Moreover, the coral mucus biofilm can prove useful as a model to comprehend the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multi- Segment System for Ubiquitous Access to Internet Services and Demonstrator' (SUITED).

assistant: **Innovation**

The convergence of mobile and Internet Protocol (IP) based technologies is now the major driving force behind the research and development of future mobile technologies, services and applications. The SUITED project aims to make a significant contribution towards the understanding and development of IP based mobile networks consisting of both satellite and terrestrial (UMTS, GPRS, W-LAN) components. This integrated system is termed the Global Mobile Broadband System (GMBS). The goals of the project will b achieved through theoretical analysis, where issues including network architecture, Quality of Service and Mobility Management will be addressed, and experimental work. The project will conclude with a comprehensive series of trials, using an integrated test-bed comprising of a prototype multi-segment infrastructure and a prototype multi-mode mobile terminal, capable of operating seamlessly with both satellite and terrestrial networks. Navigation capabilities will be integrated into the user terminal in order to enhance the performance of personal communication services and physical layer functions.Objectives:The project objectives can be summarised as follows:To define the network architecture for the provision of mobile Internet services over complementary satellite and terrestrial wireless segments and both validate the most critical inter-segment procedures and, evaluate the performance.To demonstrate the ability to provide QoS sensitive mobile services on advanced Internet scenarios via a demonstrator, which is representative of a multi-segment, network infrastructure based on the available Internet network upgraded to cope with a service scenario including the mobility and, guaranteed QoS.To develop prototypal, multi-segment user terminals families: car, large ve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'BIOMAT4CAST  - PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY MULTI-SCALE  IN SILICO LABORATORY FOR COMPLEX AND SMART BIOMATERIALS' (BioMat4CAST) under Horizon Europe.

assistant: **Objectives**

The strategic objective of the BioMat4CAST project is to implement a structural change within in the scientific management paradigm of “Petru Poni” Institute of Macromolecular Chemistry (ICMPP), Iasi, Romania, by setting up a competitive research group in the field of computational chemistry under the supervision of an outstanding researcher manager in the field of computational chemistry, Prof Aatto Laaksonen (Arrhenius Laboratory, Stockholm University, Sweden).The objectives of the BioMat4CAST project addresses directly to the targets of the Horizon Europe program: ""to support research organisations to attract outstanding researcher and/or innovator in the chosen scientific domain thus to achieve excellence on a sustainable basis"". The BioMat4CAST project results matches the Destination 2: Attracting and Mobilising the Best Talents of the Horizon Europe program.The BioMat4CAST project will raise the RTD standards of ICMPP – as the first NE Romanian Region research center having a critical mass enabling it to spread excellence in the specific field of computational chemistry able to link the Romanian computational school to the World Association of Theoretical and Computational Chemists through on-going cooperation, partnership and shearing of know-how/technical expertise. The ambition of BioMat4CAST project is to become, after the project ends, an example of good practice and a model of knowledge sharing. ""


**Keywords:** Complex biological material, High-performance computing, Machine learning, Computational Biology, In-silico design, Drug, gene transport & delivery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modelling Joint Development: Integrating Biological and Mechanical Influences' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Embryonic joint development is a complex process with several distinct stages. The first step occurs in the cartilage anlage, where chondrocytes at the presumptive joint site stop proliferating and become compacted to form what is called the interzone. From the interzone, the synovial cavity develops. Once the cavity has been initiated, the surfaces of the opposing cartilage rudiments undergo gradual shape morphogenesis so that the ends of the two bones form a functioning, friction-minimising contact surface, i.e., a synovial joint. It has been shown that mechanical forces are essential for normal cavitation of the joint, while it is not yet clear whether mechanical forces are an essential influence for moulding of the articular surfaces. If embryos are immobilised prior to cavitation, the process does not occur, while if immobilisation is induced after the cavity has formed, the cavity regresses and the elements can become fused. In this application, I propose a computational simulation of joint development, modelling cavitation of the joint and morphogenesis of the articular surfaces based on the interactions between mechanical and biological factors. The aims of the project are to 1) characterise the developing joint in 3-D in the embryonic chick; 2) calculate the forces and biophysical stimuli active in the joint over several stages; 3) create 2-D model of simple joint, 4) alter mechanical state to corroborate model predictions; 5) investigate mechanosensitive molecules and genes, and 6) upgrade model to 3-D. Such a simulation will lead to a better understanding of joint development which would have significant consequences for medical applications such as osteoarthritis and tissue engineering. This project will enable me to become an expert at the interface between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Applying an object oriented analysis and design methodology for documenting guidelines and strategies for qualitative reuse of reusable assets', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Our business objective is to build a product that is easier customisable, flexible to adapt to new needs and that is open for integration with any existing hard- and software. Important herein is the symbiosis between domain knowledge and the application of state-of-the-art software engineering techniques. It is our goal to install a software product line for (television) program planning applications that can be tailored to the specific needs of our customers. Off-the-shelf products don't work for this kind of complex business applications. Our experience shows that 80-90% of the business needs are the same for every station, but it is very important that the remaining 10-20% can be provided in a timely and cost effective way. OO Partners achieves this by using state-of-the-art software engineering techniques: object-orientation (OO) and framework technology.THE EXPERIMENTOO Partners' mission is to be a competitive broadcast management application provider. Today our product, called PSI, already covers a number of modules that manage the planning process of television broadcasting. The baseline project is the development of a cost analysis module for the broadcast planning application PSI. As in any other module of PSI, the module will be designed as a framework to allow easy customisation for different television stations. The cost analysis module will be closely incorporated in the existing PSI framework. The goal of the experiment is to evaluate how, and to what extent, the application of a proven object-oriented analysis & design methodology (OMT, BOOCH, OBA, ...) during our software development process can contribute to the following two (related) issues:Applying the OO methodology to make the existing software product line more accessible for new team members and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targetting malarial cell cycle kinases' in the context of a Sixth Framework call.

assistant: **Objectives**

Plasmodium falciparum cell cycle regulators are promising targets for novel anti-malarial drug design. This application is firmly based in the post-genomic era where the identification of novel drug targets is greatly facilitated by the availability of the P. falciparum genomic databases. P. falciparum cell cycle regulators are promising drug targets because of their predicted essential roles in regulating the pathogen's life-cycle. We have determined the structure of PfPK5. the first structure of a P. falciparum protein kinase and the first of a cyclin-dependent kinase (CDK) not derived from humans. A comparison of CDK structures from these two evolutionarily remote organisms suggests that the fold and the mechanism of inactivation of monomeric CDKs are highly conserved. The first aim of this project is to employ X-ray crystallographic studies to guide the development of potent and selective small molecule ATP-competitive inhibitors of P. falciparum protein kinase 5 (PfPK5), a member of the P. falciparum cyclin-dependent protein kinase family. Homologues of this enzyme in other eukaryotes play an essential role in regulating cell cycle progression. These compounds will be useful tools for P. falciparum cell cycle studies, and will provide lead compounds for anti-malarial drug development. The second aim of the project is to employ biochemical and biophysical methods to characterise CDK/cyclin complexes. This will explore the evolutionary conservation of the structural mechanisms that regulate the eukaryotic cell cycle. The final aim is to characterise P. falciparum cyclin 4 (Pfcyc-4) a novel member of the cyclin family that shows a distinct pattern of expression in the erythrocytic stages of the parasite's life cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HYPERMEDIA PUBLISHING, DOCUMENTATION AND COOPERATION BASED ON TECHNICAL MATERIAL THAT IS ONLINE RETRIEVABLE' under Fourth Framework.

assistant: **Concept**

HYPDOC provides an integrated system for preparing multimedia material for publishers and industrial companies. It will store this material and provide for its easy access to all authorised users in a given network, facilitating communication and computer-based cooperative work. The aim is to compensate for the absence on the market of a single tool for the simultaneous matching of key requirements such as powerful multimedia information retrieval capability, in an approach involving a suitable combination of state-of-the-art technologies and existing products, and creation of a pre-operationally tested working prototype.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Quantum Interference Enhanced Thermoelectricity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Our vision is to demonstrate that room-temperature quantum interference effects, measured recently in single molecules, can be exploited in massively-parallel arrays of molecules and used to design ultra-thin-film thermoelectric devices with unprecedented ability to convert waste heat to electricity using the Seebeck effect and to cool at the nanoscale via the Peltier effect.Although the dream of high-performance thermoelectric devices has been discussed for many years, evidence of the room-temperature quantum interference effects needed to realise this dream was achieved experimentally only recently. Building on these indirect demonstrations of quantum interference in single molecules using non-scalable set ups, we anticipate that the next breakthrough will be the implementation of QI functionality these intechnologically-relevant platforms. We shall design molecules with built-in quantum interference functionality, which can be used to engineer the properties of ultra-thin molecular films. Molecules will be designed with robust anchors to metallic and carbon-based nano-gap electrodes, which enhance electron transport and eliminate unwanted phonons.This contacting strategy is scalable from a single junction, with the potential to be replicated billions of times on a single substrate. The ability to exploit quantum interference at room temperature will enable new thermoelectric materials and devices with the ability to scavenge energy with unprecedented efficiency.QuIET is a highly interdisciplinary project that brings together internationally leading scientists from four different countries with proven expertise on synthesis, transport measurements and theoretical modelling.


**Keywords:** Thermoelectricity, molecular electronics, quantum transport, quantum interferen