RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum electrical and mechanical properties of atomic size metallic contacts' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The scope of this fellowship will be to obtain a complete quantum theoretical description of electrical conduction and mechanical behaviour in metallic contacts of nanometrical size (or nanowires). My own work has dealt, so far, mainly with theory of conduction through these nanowires. In Trieste, I will use several (new for me) theoretical methods in order to determine the geometrical and electronic structure of the wires. Once these structures are determined, my previous expertness in conductance calculations for similar systems will be applied. As a result of the combination of both abilities, a new level of detail in the theoretical description of these nanowires could be reached: the use of self consistent methods will allow us to obtain the possible intimate correlation between the mechanical and electrical parameters. Training content (objective, benefit and expected impact) The content of the project includes the learning of theoretical methods such as Molecular Dynamics and Monte-Carlo by which geometrical structures can be determined. In a further step, it will allow my assimilation of ab-initio methods by which the electronic structure can be known. In both topics, ICTP / SISSA is a world leading group, so my training in these subjects could hardly be better. The improvement of both, my theoretical and computational skills, will be enormous. Important results, to be published in international journals, are expected to be obtained. Moreover, a new collaboration research line could be opened between my origin and host institutions. Links with industry / industrial relevance (22) The fundamental knowledge of the quantum properties of these contacts is essential for the industrial development of chips at the nanometer scale (for fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanistic and therapeutic implications of microRNA deregulation for drug resistance in bile duct cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Cholangiocarcinoma (CCA) is a dismal type of liver cancer which incidence has more than doubled the last 20 years and mortality rate in Europe alone increased 37%, reflecting the limited treatment options. In >70% of patients CCA is unresectable due to advanced stage of disease at diagnosis, resulting in a 5% 5-year survival rate. CCA is characterized by molecular and clinical heterogeneity, complicating therapy and assessment of drug efficacy. Tumor heterogeneity is emphasized in limited response of therapy (drug resistance) and besides genomic instability a likely consequence of deregulated pathways under control of microRNAs (miRs). Each miR can regulate multiple genes/pathways, directly linking them to tumor heterogeneity. Deregulation of miRs can cause/control chemoresistance in other cancers, but in CCA their role is yet unclear. Thus, detailed characterization of miRs in CCA, focusing on their impact in drug resistance is urgently needed. Hence, I have 3 specific aims of this proposal: to 1) characterize the deregulated expression pattern of miRs involved in CCA pathogenesis and integrate this data with transcriptomes obtained from matched patients; 2) determine the role of deregulated miRs in control of chemoresistance, and 3) modulate by genome-editing key deregulated miR(s) targeting chemoresistant genes using the novel `CRISPR-Mir’ method. Achievement of these aims will yield key new insights into the role of miRs in orchestrating CCA progression and metastasis, as well as their involvement in drug resistance. My findings will have an impact on the society and in particular in patient outcome. Dr. Andersen, a world-wide expert in the molecular pathogenesis of CCA with a vast experience in genome medicine, will supervise the project. Successful completion of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetics and epigenetics of Type 2 Diabetes physiology' in the context of a Seventh Framework call.

assistant: **Objectives**

Failure to elucidate Type 2 Diabetes (T2D) physiology frustrates efforts to improve therapeutics. Although GWAS has identified 40 T2D genes, mostly expressed in pancreatic beta-cells, this explains no more than 10% of T2D inheritance. Up to 5% of T2D patients have dominantly inherited maturity-onset diabetes of the young (MODY), characterized by beta-cell dysfunction. Elucidating the genetics of familial early-onset T2D, using Whole-Exome Sequencing (WES) can bring breakthroughs in understanding insulin secretion physiology. DNA methylation, particularly in insulin sensitive tissues may also contribute to T2D. Newly-developed genome-wide methylation arrays can be used to identify  associations with these epigenetic elements and T2D. In the proposed project, GEPIDIAB, I will take advantage of our MODY family DNA collection and multi-tissue biobank to 1: identify novel genetic causes of familial T2D (WP1) and 2: identify DNA methylation variation associated with T2D (WP2). In WP1, unresolved MODY-X families will be studied  using WES to identify novel sequence changes. Then we will elucidate the cellular and metabolic mechanisms leading to beta-cell dysfunction caused by these novel mutations. In WP2, variation in DNA methylation at 450K sites across the genome will be studied in normoglycemic or diabetic bariatric surgery patients. Five separate tissue samples will be studied to identify tissue-specific variation, individual-specific variation and that which varies between cases and controls. We will explore whether there are T2D-specific patterns of methylation that are distinct from those in lean or obese normoglycemic subjects using bisulfite-whole genome sequencing. Overall, we will identify genome-wide methylation patterns that are cell and tissue-specific and disea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neurophysiological correlates of bilingual advantage and its contribution to cognitive reserve', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Studies reported that bilingualism strengths executive functions in elderly and delays the Alzheimer’s disease (AD) onset for five years. These findings suggest that bilingualism enhances the cognitive reserve (CR). CR is a construct that includes a set of cognitively stimulating experiences (e.g. high education level, high occupational status) that enhance brain functional connectivity, leading to better cognitive functioning and delayed clinical AD onset. Since brain functional modulations maintained for a long period of time result in structural changes, studies suggested that enhanced functional and structural connectivity provide to persons with high CR greater resilience against changes related to physiological and pathological ageing. Considering the European population ageing, study of variables related to CR is crucial to prevent the cognitive decline in elderly and for the maintenance of public health systems. The aim of this project is studying the specific cognitive processes related to bilingual advantage in executive functions and the underlying neural correlates. Studies often failed to find a relationship between bilingualism and better executive functions. These studies often focused on cognitive control to inhibit irrelevant information but recent research suggested that bilingualism is mainly related to better attentional switching abilities. Also, high CR of the participants or low difficulty of the performed task could mask a bilingual advantage due to a ceiling effect in cognitive performance. Four samples of healthy elderly (monolinguals and bilinguals with low and high CR) will perform two cognitive tasks during an electroencephalogram (EEG) recording. Neural correlates of cognitive processes occurring during the tasks performance will be studied
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cyanobacterial toxins' in the context of a Fourth Framework call.

assistant: **Objectives**

In this proposal an early warning system is developed for the development oftoxic cyanobacteria in lakes and reservoirs. The project has three parts. Theme 1The development of two population dynamical models with which the development of populations of toxic cyanobacteria can be predicted. A model will be made for scum forming species (like Microcystis) and one for dispersed species (like Planktothrix). When in spring or in early summer toxic populations have been recognized the model would be used to predict the development of this bloom. In the models hydrophysics play an important role. The model will be validated for a larger part of Europe using data from a statistical study concerning the relation of cyanobacterial growth and environmental conditions and the results of a European study (theme 3). Remote sensing will be used to incorporate the inhomogeneous character of the blooms.Theme 2The early detection of toxic producing populations and the conditions under which toxins are produced. Analytical chemical methods will be used and developed. Special attention will be paid on the mass spectrometric method (MALDI-TOF) to analyse cyanobacterial peptide toxins. The method will be compared with results from HPLC. LC-MS and ELISA. The analyses of neosaxitoxins with ELISA will be developed.he discovery of genes involved in microcystin production makes it possible toinclude DNA-based methods in the project. A PCR protocol will be establishedfor the detection of the genes involved in the microcyst in production in the most relevant species. At the end of the project methods must be available to analyse and to recognize toxic populations in field samples. To estimate how important environmental factors are for the selection of toxics trains in the lake and to estimate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Modular electroactive nanopore architectures with atomic precision'.

assistant: **Objectives**

MORPHEUS aims to advance the field of 2D carbon technology through the synthesis and characterization of electroactive nanoporous graphene (e-NPG). The project will utilize on-surface synthesis (OSS) to create complex graphene nanoarchitectures with atomic precision, via a 2-step OSS approach. This involves laterally interconnecting graphene nanoribbons (GNRs) using electroactive bridges that enable pore functionalization. These electroactive bridges will act as electrochemical gates through redox reactions, switching on/off the quantum electronic transport between GNRs, leading to the development of highly sensitive and selective chemical sensors.The key objectives of MORPHEUS are: - Atomically-precise synthesis of e-NPG with homogeneous nanometer-sized pores by interconnecting graphene nanoribbons (GNRs) with electroactive molecular bridges.- Controlling activation and deactivation of these bridges through site-specific redox reactions.- Characterizing the gas-sensitive electronic transport properties of e-NPG-based field-effect transistors (FETs). The innovative use of OSS for lateral interconnection of GNRs and the incorporation of electroactive bridges aims to achieve unprecedented control over electronic properties and device functionality. The project will be evaluated using mainly scanning tunneling microscopy/spectroscopy (STM/STS) and FET device performance measurements in the presence of different gases. This research is expected to provide new insights into quantum electronic transport in complex graphene nanoarchitectures and their potential use in quantum sensing, thus contributing to the expansion of atomically precise carbon-based materials in the Spanish research community, where the researcher plans to establish herself in the future.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Narratives'.

assistant: **Objectives**

How the concept a European worldview is worked out or makes sense is only valuable against the backdrop of the voice of the people of the community itself. Almost never have these voices been heard within their own daily environments, as they reflect and express both local and national concerns. This conference aims to highlight, and place centre, the constructive role of European narratives as a central source of meaning in cultural interaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'MEMbrane based Purification of HYdrogen System'.

assistant: **Objectives**

Project MEMPHYS, MEMbrane based Purification of HYdrogen System, targets the development of a stand-alone hydrogen purification system based on a scalable membrane hydrogen purification module. Applications are for instance hydrogen recovery from biomass fermentation, industrial pipelines, storage in underground caverns, and industrial waste gas streams.The consortium consists of six partners including two universities, two research institutes, and two companies from five different countries. The overall budget totals 2 M€, with individual budgets between 220 and 500 T€.This project will utilize an electrochemical hydrogen purification (EHP) system. EHP has proven to produce high purity hydrogen (5N) while maintaining low energy consumption because the purification and optional compression are electrochemical and isothermal processes. A low CAPEX for the EHP system is feasible due to the significant reductions of system costs that result from recent design improvements and market introductions of various electrochemical conversion systems such as hydrogen fuel cells. In detail, the purification process will be a two-step process. A catalyst-coated proton exchange membrane will be assisted by one selectively permeable polymer membrane. Standard catalysts are sensitive to impurities in the gas. Therefore, alternative anode catalysts for the EHP cell, an anti-poisoning strategy and an on board diagnostic system will be developed. The resulting MEMPHYS system will be multi-deployable for purification of a large variety of hydrogen sources.A valuable feature of the MEMPHYS system is the simultaneous compression of the purified hydrogen up to 200 bar, facilitating the transport and storage of the purified hydrogen.The MEMPHYS project offers the European Union an excellent cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development and Manufacture of High Temperature Composite Aero Engine Parts', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cobham will develop and manufacture lightweight carbon fibre reinforced polymer matrix composite test components for the SAGE 4 Geared Turbofan demonstrator. The components will be manufactured from suitable high temperature resistant thermoset resin which is capable of a continuous service temperature of 350°C. Initial working sessions shall be held to review the candidate components and to develop the draft technical requirement specifications. The composites manufacturing process selection shall be dependent upon the components to be manufactured. A study shall be carried out by Cobham to identify the most cost effective manufacturing route which achieves the required performance requirements for the selected components.Development of the selected manufacturing process will be conducted in collaboration with MTU so that key design-for-manufacturing requirements are captured. Demonstrator components will be manufactured in accordance with MTU specifications and drawings. Material characterisation data will be generated for unaged and thermally aged test coupons in order to validate the composite designs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Expert support to Implementation Working Group 5 of the SET Plan - Energy Efficiency in Buildings' (IWG5-CSA).

assistant: **Concept**

IWG5’s brief is to deliver the Implementation Plan on energy-efficient solutions for buildings, requiring Member States to put in place measures favouring both innovation in building design and energy technologies for buildings, and the uptake of these technologies by builders.EURAC will offer scientific support establish the performance of eco-building technologies today and assist the IWG5 in setting realistic but ambitious performance targets, then monitoring progress towards them. WIP will organise study tours to buildings that set the standard in eco-renovation or construction. These will be opportunities for IWG5 members to meet the actors responsible and the people who live in or near them to collect their views.ECTP and EUREC will focus on informing IWG5 of the latest thinking around eco-buildings coming from lobbies (NGOs, associations, public authorities, leaders of initiatives like the Mission for 100 Climate-neutral Cities by 2030) and building bridges to the thinkers in those lobbies. Digitisation is a major theme coming in the new proposed EPBD. We will align the EPBD’s innovation-related comitology committees with IWG5.Fed with ideas, quantitative analysis and with white papers produced by Task Forces tackling specific innovation-related topics, the IWG5 will update its Implementation Plan. A new release will come every year and be given lots of publicity. The IWG5 members will be invited to promote it within their ministries, in order to deliver it with appropriate national policies.IWG5-CSA will play close attention to the revision of National Energy and Climate Plans in 2023 (a joint activity with ETIPs) and, depending on the final legislated EPBD, National Building Renovation Plans in 2024. These plans are where Member States lay out the policies to r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Research Visibility 2011 - Macedonia' to be submitted under Seventh Framework.

assistant: **Abstract**

Researchers Night as event in 2011 is organized in the RM for the fourth time. The previous events were highly public appreciated and particular by the young people. These manifestations were the first directly public contacts between the researches and citizens about the role and a wide range of activities of researchers and science as whole for creation of national wealth and popularization of achievements in the field of the public.  The intention was to reach across the young and general public with opportunity to promote the research careers and science as essential for sustainability and improvement in the quality of everyday live, economic and social development and making closer the society for further integration in the European Union.The increasing success in terms of number of participating people and results of public opinion surveys made in the last two years, which were carefully examined, justifies for preparation the next event, improving the understanding and appreciation of science by the public by involving more people and engaging young people in activities with the researches disciplines. Since, the last year for the first time we have a project consortium, it was taken into account the interest presented on the Researchers’ Night by the visiting research organizations to be more actively involved in the Researchers’ Night and thus the consortium was extended with some new partners.  The surveys, also showed, that the people present a great interest for Researchers’ Night to become a regular manifestation in their city, as the best geographically location, where they may interact with the researchers on the national level.The main objective of the Researchers’ night as pan-European event, consists of bringing the researchers closer to the large publ