RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metal Hydride Heat Pump for Waste Heat Recovery in Vans Refrigeration Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

According  to Global Industry Analysis Inc., refrigerated transportation world market will reach 5 billion € by 2015. Increasing awareness about food safety, consumer spending on high value perishable goods and replacement of refrigerated vehicles are driving the growth in refrigerated transportation market. Approximately 650.000 refrigerated road vehicles are currently in use within the EU.The increase of fuel price is becoming  a crucial aspect for cold transport companies, since the continuous growth of oil price is leading to a drastic increase of operative costs.Refrigerated vans and trucks spend 10.000-100.000 liter of fuel/year and 8% about of this amount is due to refrigeration, today performed by energy-consuming compressor-driven Air Conditioning Systems (ACS) fed by the electricity generated by an alternator.The project here presented deals with the development of an innovative Sorption Heat Pump, based on the adsorption/desorption of a gas stream (hydrogen) on solid beds and able to produce cold exploiting the waste heat generated by the thermal engine and thus saving 800 – 8.000 fuel liter/years for each van/truck.The sorption heat pump to develop is a Metal Hydride Cooling System (MHCS) based on hydrogen adsorption/desorption on solid beds. Such a technology allow reaching the highest compactness and Specific Cooling Power (SCP, i.e. the ratio between cooling power and system total weight) comparing the other heat-driven heat pump units, up to 50 W/kg versus 25 W/kg of silica-gel technology.The main S&T objectives of the HP-ACS are:1.developing, testing and characterizing of suitable materials for cold van (operating temperature = 4°C).2.Designing and engineering a retrofit HP-ACS system, to be easily assembled in cold van and with the scope to minimize sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Network Young Membrains - Meeting 2001 - a PhD EuroConference on membrane technology' (1998-2002).

assistant: **Innovation**

The third meeting of the Network Young Membrains" will be held in Delft (The Netherlands) and is organised by the Delft University of Technology in cooperation with the Twente University, both located in the Netherlands. The first two meetings of the NYM were held in Germany, as the IVT in Aachen being the initiator of NYM in 1999. To emphasise the European network and the importance for the EU it was decided that each year the meeting has to be organised by a different EU country. NYM is a PhD student organisation dealing with membrane technology, with the goal to bring together creative people, who are currently researching membrane technology at the University or in Industry. It is meant to create a communication platform on which membrane researchers can exchange ideas. This will serve to enhance knowledge and abilities as well as to build-up useful contacts in the field of membrane technology. Therefore by establishing a network of persons and knowledge the competitiveness of European research will be strengthened. Young Membraines who join this community will benefit from its advantages and synergistic effects. The NYM consists of different activities such as annular meetings all over Europe, an internet-database containing an overview on the scientific work in this field of research, and excursions to membrane plants and companies improving the relationship between universities and industry.The 'Network Young Membrains - Meeting 2001' as PhD EuroConference on membrane technology is a central part of this broad actions. Membrane technology itself is already an important unit operation in industrial processes in several human related fields (e.g. waste water treatment, drinking water supply, chemical processes). In the future this innovative separation technology w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanism based modelling of plastic deformation' (MECHAMODE) targeting Seventh Framework.

assistant: **Abstract**

A fierce competition between structural materials such as steels, aluminium alloys, magnesium alloys and polymers takes place in the transportation area. Design concepts for light-weight structures require tailored materials, which generally combine high strength and low weight. Advanced high strength steels (AHSS) exhibit exceptional properties that can lead to a drastic reduction in the weight of structures and, consequently, significant energy savings and emission reduction. However, due to their high strength, many new manufacturing issues are emerging and failure phenomena during service must be carefully evaluated in order to avoid catastrophic events. To use the full potential of these steels, accurate tools for the prediction of deformation during the forming process and a proper failure characterisation is required. In this proposal constitutive models based on deformation mechanisms will be developed, implemented into the framework of finite elements, verified and validated. This will be done by means of a multidisciplinary approach involving metal physics, advanced mechanical characterisation, process monitoring and technological tests. To achieve the goal, experimental procedures have to be optimised in order to feed constitutive equations with the necessary parameters. Special emphasis will be put on the micromechanics of deformation twinning, which is one of the dominant mechanisms in TWIP (twinning induced plasticity) steels and magnesium. Novel numerical tools will be developed making it possible to perform numerical predictions of forming processes and in-service performance. Together with experienced scientists in Korea microstructure-property relations will be established for newly developed steel materials. The proposed methodology itself, however, c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regional innovation strategy for the northeast-planning region of Bulgaria' under Sixth Framework.

assistant: **Concept**

The High-Technology Business Incubator Varna in partnership with the Alliance of the regional authorities in the North-East Planning Region, the Bulgarian Ministry of regional development and public works, the University of Western Macedonia in Greece, t he Region of Liguria and the Region of Abruzzo in Italy will implement the project for elaboration of a regional innovation strategy for the North-East Planning Region of Bulgaria. The project overall objective is to create and sustain an environment fostering the innovations in the North-East Planning Region of Bulgaria through further development and improving the regional innovation policy.The project goal corresponds with the Research and innovation" theme of the specific programme, which addresses creation of innovation-friendly environment throughout the EU and stimulation of technological innovation and the setting up of innovative technology businesses. The project partners will provide support to the regional key actors for improvement and further development of regional innovation policy by focusing upon concrete actions and measures to secure the economic growth, the global competitiveness, employment and reduce of the territorial differences in the North-East Planning Region of Bulgaria.The main emphasis of the concrete action plan will be put on the developed existing sectors and the emerging sectors of the regional economy in order to improve the innovation capabilities of the region and thus to contribute to its overall development.  The regional innovation strategy will be the basis for sustainable RIS process and will improve the innovative capacity of the region. The proven experience of the three EU member regions in RITTS/RIS projects will allow the transfer of good practices and will ensure the succ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of Kinetoplastida Flap Endonuclease Inhibitors in Search for Novel Therapeutics' (2014-2020).

assistant: **Innovation**

We are searching for Kinetoplastida flap endonuclease (FEN) inhibitors as a base for potential therapeutics for parasite infections, for which there is significant unmet clinical need. Kinetoplastida are flagellated protists responsible for 3 neglected human diseases. We will target the FEN enzymes from Trypanasoma cruzi and Leishmania species, the organisms causing Chagas disease and leishmaniaisis respectively. FEN  activity is crucial for the survival of all organisms tested so far from mouse to bacteria, including Trypanosoma. We will identify specific inhibitors of Kinetoplastida FENs as the basis for future development of urgently needed new therapeutics. This multidisciplinary structure-based inhibitor design project will involve in vitro and in silico screening, protein crystallization, rounds of inhibitor design and finally in vivo potency and toxicity experiments. The project will be overseen by Prof Sayers who has 30 years of experience with nucleases and who has founded two spin-out companies. His group is complemented through collaboration with a parasitologist Dr Helen Price (20 years research experience), who has been actively involved in developing antiparasitic agents. The experienced researcher, who has a strong protein biochemistry and crystallography background, is returning to academic research after almost 4 years outside science. Ultimately, the experienced researcher is aspiring to an academic career in translational medicine rooted in state-of-the-art basic research but with the skills and experience to synergise with the pharmaceutical sector.


**Keywords:** Inhibitor assay screening, docking, virtual high throughput screening, nuclease inhibitors, mechanistic enzymology,  in vivo toxicity experiments, antiparasitic agents, neglected tropical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Workshop on forestry co-operation among asem partners' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The workshop is an integral part of the initiation of an ASEM project Forestry Conservation and sustainable Development endorsed by Leaders at the Third Simmering on 21st October, 2000, Seoul. Finland is setting up an ASEM Forestry ExpertsTM Network, the Network being a specific component of the project. The workshop will be the organisation meeting for the Network. The workshop is planned to be held in China in June 2001. The Experts TM Network Coordination in the University of Turk Centre for Biodiversity is the main organiser of the workshop, and the Chinese Ministry of S & T acts as a host partner.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From 1D to 3D Hadron Structure with exascale lattice QCD simulations' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Atomic nuclei form the core of everything in terms of visible matter and are made out of nucleons viz. protons and neutrons. Nucleons are made out of quarks and gluons, which cannot be isolated due to confinement.When we try to answer fundamental questions such as “what is the origin of mass and spin of the nucleon?”, we know that the answer lies within Quantum Chromodynamics (QCD), the theory describing the strong interaction piece of the Standard Model (SM). The nonperturbative nature of QCD, however, renders the answer extremely hard to obtain.Yet, despite the formidableness of the task, great progress has been made in first principles calculations of maps that describe the structure of nucleons. Starting from the simpler 1D case, we were able to study, using lattice QCD simulations, Parton Distribution Functions (PDFs) of quarks and gluons, hence paving the way towards the extraction of 3D maps, coined as Generalized Parton Distributions (GPDs). HADaSTRaLS' goal is the first ab-initio high precision extraction of quark and gluon PDFs and GPDs of the nucleon with fully accounted systematics.What places me in a unique and privileged position and time for achieving this ambitious goal is that I will be able to (I) rely on an arsenal of theoretical and numerical tools that have been sharpened within my team over the past decade, and (II) take advantage of the unparalleled progress of algorithms and the advent of exascale supercomputers.HADaSTRaLS will open new avenues in hadron physics, with applications that range vastly beyond the theoretical understanding of nucleon structure. Our results will serve as a quantitative theory guide for the upcoming experiments at the US Electron-Ion Collider (EIC) and Large Hadron Collider (LHC). They will provide constraints for model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel mesenchymal stem cell based therapies for articular cartilage repair', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Once damaged articular cartilage has a limited reparative capacity and thus lesions often progress to arthritis. This has motivated the development of cell based therapies for the repair of cartilage defects such as autologous chondrocyte implantation (ACI). Such therapies are limited in two ways. Firstly, they do not result in the regeneration of hyaline cartilage and hence the repair is temporary. Secondly, widespread adaptation into the clinical setting is impeded by practical issues such as the high fiscal cost and time required for culture expansion of chondrocytes.  The applicant is of the belief that both issues cannot currently be addressed by a single new therapy. Therefore the proposed project will put forward separate solutions to both issues. The first theme of the project will determine whether freshly isolated (not culture expanded) infrapatellar fat pad derived cells, embedded in a hydrogel containing microbead-encapsulated growth factors, can used to engineer functional cartilage tissue. A component of this theme will involve magnetic microbead enrichment for cells with surface markers associated with highly chondrogenic cells. Theme 2 of the proposed project will explore an alternative therapy for cartilage defect repair.  Specifically, the objective is to tissue engineer in vitro a functional tissue with a zonal structure mimicking that of normal articular cartilage using mesenchymal stem cells. It is hypothesised that such a zonal structure can be generated by controlling the oxygen tension and mechanical environment within the developing tissue. The final theme of the project will be to determine if repairing high-load bearing cartilage defects using either tissue engineering therapies will result in significantly improved repair compared to ACI in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The genetic and epigenetic determinants of enhancer-promoter contacts in mammalian evolution' (EVOCHIC), addressing dissemination and exploitation.

assistant: **Impact**

Gene regulation is fundamental to biological diversity, driving differences between cell types within an organism and contributing to variation between species. DNA regions known as enhancers play a critical role in this process. Enhancers can be located millions of base pairs away from the genes they regulate, interacting with the promoters of these genes through 3D contacts within the nucleus. How enhancers find their target genes remains largely elusive. Evolution offers a unique “natural perturbation experiment” to study the principles of enhancer-promoter communication. Enhancers, and especially the sequences spanning enhancer-promoter contacts, evolve faster than the gene expression patterns they control. This raises important questions about the genetic and epigenetic factors that sustain and drive the evolution of long-range gene regulation. To address these questions, my computational project will leverage an unpublished, high-resolution dataset on enhancer-promoter contacts from five mammalian species and three tissues, along with corresponding genomic sequences, enhancer annotations, and gene expression data. My analyses will: (1) map how enhancer-promoter contacts co-evolve with genomic sequences, chromatin states, and gene expression, (2) establish how large-scale genomic rearrangements disrupt or constrain these contacts, and (3) develop and train deep learning models to predict DNA sequences underpinning the evolution of enhancer-promoter contacts. By integrating functional genomics, evolutionary biology, and machine learning, this project will uncover the mechanisms behind the evolution of long-range gene regulation, with broad implications for understanding non-coding genetic variation in evolution, disease, and synthetic biology. The fellowship will en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neutrophins and synaptic plasticity in the spinal cord' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content Brain derived neurotrophic factor (BDNF) is neurotrophic factor for sensory neurons of the dorsal root ganglia. In addition to its trophic role, it has recently been demonstrated that this factor can acutely modify the strength of synaptic connections. Here we aim to investigate the role BDNF plays in the plasticity displayed by neurones of the spinal cord. Using an in vitro electrophysiology preparation, the pharmacology of C-fibre evoked ventral root reflexes will be assessed in BDNF knockout mice. It is also planned to characterize a new BDNF promoter IV knockout animal that should confine BDNF deficits to the periphery and use this mouse to determine the function of BDNF after nerve injury. Gene transfer techniques are also being developed in the laboratory using the particle mediated system (Gene gun) to replace or overexpress missing gene products in order to rescue physiological deficits seen in the knockout mice. Training content (objective, benefit and expected impact) By training in Dr. Lewin's laboratory I will gain experience of working with transgenic animals and learn standard molecular biology techniques essential for the analysis of these animals. I will also have the opportunity to learn an important in vitro electrophysiology preparation. These new technical skills will enable me to more flexibly address important basic questions in my field eventually as an independent researcher. Links with industry / industrial relevance (22) The results of the present studies may well lead to the development of drug development strategies for the treatment of pain and sensory neuropathies associated with peripheral nerve injury.