RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tumour suppressor p53: structure, stability and novel anti-cancer drug development' (P53LAZARUS).

assistant: **Concept**

Elimination of the tumour suppression activities of p53 is common to all cancers. p53 is inactivated directly by mutation in ~50% of human cancers, and ~30-40% of these oncogenic mutants are just temperature sensitive, ts, being active at lower temperatures. Wild-type p53 spontaneously denatures, with a half-life of 10-20 minutes at body temperature, and ts mutants far faster. The melting temperature and half life of ts oncogenic mutants can be raised by small molecules. The mutant Y220C is particularly propitious for study and as a target for therapy as the mutation makes a druggable cavity. We discovered lead compounds for a novel class of anti-cancer drugs that could be used to treat 70-80,000 new cases of cancer per annum worldwide via reactivating Y220C. I present a programme to understand the basic principles of stabilising Y220C in particular and the thermodynamics and kinetics of ts mutant proteins in general. Such studies may aid the development of lead compounds for reactivating Y220C into prospective drugs and will act as a paradigm for development of the ¿holy grail¿ of a generic p53-reactivating drug. This is not a classical drug screening programme but a fundamental study on how to stabilise proteins whose poor stability causes disease, and which pulls together the twin interests of the applicant in fundamental protein folding and the structural biology of p53. I will investigate the biophysical and structural characteristics of how to stabilize proteins by small molecules using the leads thrown up by the drug-screening programme. Even if none of the leads make it to the clinic, they will be important substrates for the structure-activity studies on the mechanisms of protein stabilization, which will be of general importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Research Infrastructure on Highly Pathogenic Agents' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In the context of the emerging and re-emerging infectious diseases involving highly pathogenic microorganisms, European countries have to be well-prepared to face such threats. However, the Biosafety Level 4 (BSL4) capacity in Europe is not sufficient enough to cover the efficient development of diagnosis, prophylactic and therapeutics means against these pathogens. Moreover, there is no global coordination of activities and harmonization of practice in this field. Therefore, the ERINHA project proposes the creation of a top world-class BSL4 research infrastructure that will address the actual European capacity sparseness. The project plans to conduct five main actions which are: (i) Building additional BSL4 areas in several existing BSL4 laboratories, (ii) Building BSL4 laboratories in strategically selected EU countries that are lacking one, (iii) Building a support infrastructure around BSL4 laboratories mainly dedicated to host scientific visitors and staff, (iv) Setting-up the user access to the ERINHA infrastructure, (v) Establishing coordination capacities for efficient dispatching and control of all activities. For 46 months, the ERINHA Preparatory Phase  will focus on (i) Identifying relevant sites in Europe for new BSL4 constructions or major upgrades, (ii) Getting political and financial commitments from National, European or International concerned entities to support construction, (iii) Establishing a secured and validated financial plan for construction, (iv) Defining and implementing an appropriate governance and legal framework, (v) Harmonising  and disseminating common procedures related to L4 biological resources, biosafety and biosecurity management, (iv) Defining and implementing joint training programs to operate in BSL4 facilities, (vii) Identifyin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ROBotic Open-architecture Technology for Cognition, Understanding and Behaviors' (Robot-Cub).

assistant: **Concept**

Robot-cub scientific goals are: (1) to create and open physical platform for embodied research that can be taken up and used by the research community involved in embodied cognition, and (2) to advance our understanding of several key issues in cognition by exploiting this platform in the investigation of several cognitive capabilities. This will be achieved through a program of experimental research, drawing on our broad multidisciplinary background in human developmental psychology, physiology, cognitive robotics, mechatronics, and perceptual science. To achieve this goals an embodied system will be constructed able to learn how to interact with the environment through manipulation and gesture production/interpretation, and how to develop its perceptual, motor and communication skills to perform goal directed manipulation tasks. The embodied cognitive system (the CUB) will be shaped, physically and mentally, like a human child and it will be designed as an open system. This objective will be achieved by jointly designing the mindware and the hardware: the CUB, with the goal of providing the scientific community with a set of physically instantiated tools indispensable to study cognition. The mindware of Robot-cub will be designed taking inspiration from the way human children progressively learn about their own bodily skills, how to interact with the external world, and eventually how to communicate with other individuals.  In order to foster the adoption of the CUB platform by other scientists Robot-cub will use 25% of the budget to: (1) create a support and training site where copies of the platform will be maintained; (2)  build several copies of the robotic platform to be used by other laboratories as a part of a research grant resulting from (3) a competitive cal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The hidden heritage of modern logic', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project's aims are the transcription from shorthand and study of the writings of Kurt Gödel, Gerhard Gentzen, and Paul Bernays on the main problem of the foundations of mathematics, namely the consistency of analysis. These rich sources have remained inaccessible because of their archaic shorthand. Previous work by the PI on Gödel's and Gentzen's shorthand notes has led to stunning discoveries published in many articles and eight books, but it has left the said main problem untouched. The most important uncharted source in Gödel are his 16 ""Arbeitshefte,"" each running up to a hundred pages, and developing topics such as intuitionistic analysis and computable functionals. With Gentzen, the main sources, in another shorthand, are his two long series of notes, the ""WA"" (Consistency of analysis) and the ""BTIZ"" (Proof theory of intuitionistic arithmetic). With Bernays, the main sources are his detailed notes for two lecture courses on logic in Göttingen, in 1927 and 1929-30 that surpass by a wide margin anything known before about the birth of today's logic. The first phase of transcription and translation into English of the project aims at finishing volumes that contain all these source materials.  After the first phase, a second, interpretive phase of study will be carried through. This is done in collaboration with six leading experts, chosen from different domains so that their expertise as a whole encompasses the topics and results uncovered by the first phase of the project. The project as a whole points at a new approach to the historical study of the development of science and philosophy: It is estimated that there exist thousands of exact recordings of lecture courses in shorthand by students, what are called ""Mitschriften.""  The study of these vast sou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Real-time understanding of dexterous deformable object manipulation with bio-inspired hybrid hardware architectures' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ability to perceive and understand dexterous object manipulation from visual information, irrespective of an object’s physical characteristics, is critical for next generation robotic systems. It enables fluent interaction outside the highly constrained environments of today’s applications and allows robots to enter domestic settings and natural environments. Many approaches have been proposed to this end, but to enable real-time performance, all of them need to severely restrict model detail, degrees of freedom of articulated objects, and/or deformation complexity. The real-time aspect is critical since the perception of deformable objects under manipulation seems to be a dynamic process, in which specific actions may be efficiently used as active exploration primitives towards model abstraction. This requires closed-loop perception-action cycles. In this project, the candidate will develop a theoretical communication framework that removes a critical obstacle in current systems: the sensory/semantic communication bottleneck. In accordance with biological vision systems, the feedback and feedforward communication between dense low level sensory and compact high level semantic representations will be shaped using visual attention methods. An internal model representation will be developed that supports varying degrees of invariance to an object’s physical characteristics, and the action state space will be reduced by considering objects together with their manipulators. The candidate will also realize the communication framework as a real-time hybrid architecture by combining conventional (CPUs) with graphics processing units (GPUs).By providing multiple relevant contributions across the spectrum of the FP7 objectives in terms of its potential to advance robotic man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ANalogue In-Memory computing with Advanced device TEchnology' in the context of a Horizon Europe call.

assistant: **Objectives**

Every day we generate, process and use a massive amount of data. Searching a keyword on the internet, choosing a movie for the weekend and booking our next holiday are just a few simple actions that rely on data-intensive algorithms in the cloud, such as data search, recommendation and page ranking. The energy cost of computation is high: it has been recently reported that training a relatively large neural network produces the same carbon dioxide of 5 cars in their whole lifetime. Data centres use an estimated 200 terawatt-hours each year, corresponding to 1% of the global demand. With the spectre of an energy-hungry future, it is essential to identify novel concepts, novel algorithms and novel hardware for streamlining the computing process.My preliminary research has shown that computing energy requirements can be reduced by closed-loop in-memory computing (CL-IMC) that can solve linear algebra problems in just one computational step. In CL-IMC, the time to solve a certain problem does not increase with the problem size, in contrast to other computing concepts, such as digital and quantum computers. Thanks to the size-independent computing time around 100 ns, CL-IMC requires 5,000 times less energy than top-class digital computers at the same bit precision. These preliminary results show that CL-IMC is a promising new computing concept to reduce the energy consumption of data processing.My project will develop the device technology, the circuit topologies, the system-level architectures and the application portfolio to fully validate the CL-IMC concept. A novel memory technology that is immune to wire resistance effects will be developed. CL-IMC integrated circuits will be designed with standard CMOS technology. System-level architecture and application exploration w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolution in fragmented plant populations: plant genetic variation, mating system, fitness, and natural enemies' (FRAGEVOL).

assistant: **Concept**

The scientific objectives of the proposed research are to examine potential evolutionary changes in plant populations occurring in habitats fragmented and threatened due to human activities. The project aims to examine the evolution of plant-herbivore/path ogen interactions as well as plant mating system evolution in fragmented plant populations, and to further link interactions with natural enemies to mating system evolution. Experiments will be conducted in field, greenhouse and in laboratory and multidisc iplinary methods, including molecular genetic methods, will be intergraded. The results will increase our understanding on the evolutionary processes taking place in fragmented habitats and has important implications for conservation biology. The proposed research and mobility provides a young female scientist an opportunity to work in a high quality international research group and to learn new research methods, bringing along skills, collaboration and networking essential for widening her career prospects . The fundamental principle of `European added value can be applied in cases where joint research is of interest given the cross-border nature of the problems involved. Conservation biology, the major topic of the proposed research, is a discipline where i nternational collaboration and integration of research resources and knowledge are specifically and urgently needed. Fragmentation and degradation of habitats and loss of biodiversity are global and shared problems, and the welfare and sustainability of ec osystems are of common interest. As Europeans can be considered progressive in conservation matters both in legislation and in research, investing in high quality research on conservation biology with international collaboration and networking would provi de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Demonstration of an in vitro test for excitotoxicity based on early response gene measurement' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the project is to demonstrate the technical viability and superiority of a new in-vitro test for excitotoxicity based on early response gene measurement.  In previous EU BRIDGE and BIOTECH-1 research contracts (CT-900182 and CT 930224), some of the applicants (Partner B and 2 sub-contractors) have shown that delayed but progressively elevated c-fos mRNA expression is associated with excitotoxicity and that a ratio measurement of c-fos expression at 240/30 min after toxic insult of mouse neuronal primary cultures correlates with excitotoxic outcome. This has been shown to form the basis for a simple in-vitro assay using c-fos mRNA levels as a predictive index. This in vitro test has a significant in vivo relevance because sustained c-fos expression has been shown to be associated with neuronal apoptosis and developmental failures.  Thus we have established original and novel research results which have allowed us to develop an in vitro toxicity test for use in the screening of chemical compounds for their toxicological and pharmacological potential.  The proposal content is intended to prove the technical viability and superiority of the new test in regard to:  - reproducibility, reliability and robustness for technology transfer, - existing methods used to indicate excitotoxicity, - proving the test in comparison to other assay methods, formats and end-points, - proving the test in an industrial context.  In this manner at the end of the project we will have accumulated data on these aspects of the new test, and will have disseminated this information to an extended audience of scientists, regulatory bodies, Industry Platform, ECVAM and European Industry.  The partners in this project include the inventors, three end-users, a synthetic organic chemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Heating And Cooling Know-how and Solutions' (HACKS) targeting Horizon 2020.

assistant: **Abstract**

The objective of Heating And Cooling Knowhow and Solutions (HACKS) is to achieve market transformation for heating and cooling (HAC) appliances by motivating consumers to replace old and inefficient equipment with new energy efficient equipment; and to encourage solutions that consume less fuel, lower energy bills and improve users’ comfort and health. In the EU, almost half of all buildings have individual boilers installed before 1992, with efficiency of 60% or less. The associated energy savings of a speedy replacement are immense. To achieve these goals, 17 HACKS partners in 15 countries will raise awareness on HAC economic and environmental benefits via a communication campaign, and 15 dedicated national online platforms that will provide clear, understandable information. The focus will be on HAC appliances (e.g. boilers for space and water heating, local space heaters, etc.), but also on solutions that lower the energy consumption and avoid the installation of new equipment (shading systems, thermostats, taps and showerheads). HACKS will engage consumers by assisting them during the purchasing process of new HAC equipment. The online platforms will provide tools to receive customized information, interactive comment functions, product information, and direct links to the suppliers of the product. The online platforms will also provide guidance on how to improve consumers' situation while avoiding the purchase of unnecessary equipment as well as how to use and maintain devices.Finally, HACKS will work with all relevant stakeholders (“the multipliers”) that participate in the decision-making process of consumers by setting up strategic partnerships to promote and facilitate the purchase of energy efficient installed appliances. HACKS will place a strong emphasis on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Giga-Hertz Laboratory Experiment for Axion Dark Matter', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The nature of the dark matter, making up most of the mass of the universe remains a mystery. The G-LEAD project aims at building an original experiment to test one of the favorite hypotheses for what dark matter could be : axions. Axions have been hypothesized in the late seventies and have been extensively searched for ever since. They elegantly solve the strong CP problem of the Standard Model and constitute a natural candidate for dark matter. Axions are expected to be very light particles and they would mix with photons in an external magnetic field. If dark matter is made of axions, a metal/air interface in a magnetic field would emit GHz radio waves. I hereby propose to build the first experiment aimed at producing and detecting this axion-induced interface radiation. As opposed to all other experiments, the G-LEAD experiment is designed to be broadband, and its setup is based on a simple and robust design. It will likely constitute the world-leading experiment in terms of sensitivity in its mass range during the course of the project. Beyond the publication of candidate signals or exclusion limits on axion parameters, prototypes will be built in order to make a proposal for a large-scale broadband experiment. The project relies on a pathfinder experiment conducted at CEA Saclay and will benefit from existing local installations. Planned realizations include a new spherical cap, a large aperture 3 T magnet, modules of magnetized interfaces, new antennas and radiometers. Two postdoctoral fellows and a PhD student will be hired. An outreach and specialized workshop program is also proposed.