RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A new approach for developing a less immunosuppressive tuberculosis vaccine' to be submitted under Sixth Framework.

assistant: **Abstract**

Infections due to Mycobacterium tuberculosis cause over 2 million deaths/year. A major problem in combating tuberculosis is the insufficient efficacy of the current vaccine, M. bovis BCG. This is due to the fact that BCG induces, apart from protective Th1 cytokines Il-12 and IFN, also the Th2 cytokine IL-4 and the immunosuppressive cytokine IL-10. Together, this response results in subversion of an adequate protective immunity.Current data suggest that two mycobacterial glycolipids, lipoarabinomannan (LAM) and phenolic glycolipid (PGL) play an important role in this immunosuppression. For LAM it has been proposed that especially the terminal mannose residues, the mannose cap, are responsible for its immunosuppressive activity. We will use a new strategy to overcome these known problems of inefficacy by making less immunosuppressive BCG strains that lack PGL and/or (parts of) the mannose cap.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Supramolecular Chemistry in Medicine:Towards Complex Molecular Biomaterials that are Indistinguishable from Nature' under Seventh Framework.

assistant: **Concept**

This ERC proposal aims to bridge the gap between supramolecular chemistry and regenerative medicine by defining a new area of ‘supramolecular medicine’ in which supramolecular chemistry will be used to solve medical and health problems. Understanding of tissues, cells, and the interactions occurring at the molecular level in natural systems is prerequisite to intervene in and stimulate processes in the body, in order to perform regenerative medicine. Because all processes taking place in our body are based on supramolecular interactions between molecules that are dynamic in nature and have certain on-off rates, we anticipate that biomaterials brought into the body should display this same dynamic behaviour, and should be able to adapt to the tissue they encounter. Therefore, in the field of regenerative medicine there is a need for new biomaterials that are supramolecular in nature and are indistinguishable from their natural counterparts.Here we describe the design of supramolecular biomaterials that can be applied as synthetic extracellular matrices and synthetic cell-like microcapsules. By designing these synthetic systems as indistinguishably from nature we propose to get more insight in the processes occurring in nature. At a fundamental molecular level several molecules will be brought together to form bioactive complex molecular assemblies. Control over the introduction of bioactivity is necessary for selective interactions with specific cells and (parts of) tissues. These design principles will be applied to make different biomaterials that can be brought to the patient as synthetic extracellular matrix gel-like materials for stem cell incorporation, free-standing membranes for the development of bioartificial kidneys, and microcapsules specifically binding to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Adaptable Surface with Optical Fiber Sensing for Pressure-Tension Relief' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

IASiS addresses pressure ulcer incidence and treatment and aims to develop and demonstrate an Intelligent Adaptable Surface for serving as the skin/machine interface in therapy beds and wheelchair seating systems. This surface is envisaged to be capable of redistributing the pressure, strain and shear applied on the skin. A controller and an algorithm optimizes the load-time curve as pre-specified by the pressure-duration threshold curve, thus protecting the tissues against prolonged and excessive epidermal pressure-shear. This will in turn prevent the onset or deterioration of pressure ulcers. Diagnosis and prevention will rely on intelligent optical fiber sensing devices that can identify the values and coordinates of excessive epidermal loadings and will provide feedback information to an adaptable mattress or seat mechanism. This adaptable mechanism comprises of self-shaping elements and is responsible for relieving pressure and strain in a timely manner according to the information received by the sensing modules. To this end, IASiS intends to develop optical fiber-based two-dimensional pressure/strain/shear sensing elements and demonstrate their performance for the first on rehabilitation applications. It will also integrate the intelligent fiber-based sensing surface with the adaptable surface mechanism, and finally IASiS will evaluate the performance of the developed Intelligent Adaptable Surface through extensive Laboratory as well as Clinical Trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of oxy-hydrogen flame for welding, cutting and brazing' in the context of a Seventh Framework call.

assistant: **Objectives**

The oxy-acetylene flame has been used very widely in industry for many years and enjoys several positive characteristics including a high combustion temperature, wide availability, trained workforce and process versatility. However, it also has some drawbacks which are becoming more significant with increasing health and safety and environmental concerns; having significant quantities of highly combustible gases is undesirable; dedicated training on safety aspects of handling oxy-acetylene; the production and transportation of large quantities of combustible gas is damaging to the environment.In project SafeFlame, an alternative to oxy-acetylene heating will be developed, validated and exploited, particularly for SME fabricators.Oxy-hydrogen flames can be generated by the combustion of oxygen and hydrogen produced locally using an electrochemical cell. This approach has the following advantages over oxy-acetylene heating:•The cell is highly portable, reducing transportation costs and increasing the flexibility of the process.•The fuel is water which is widely available and low cost.•The process requires electricity to generate the gases but is >60% efficient.•Storage of combustible gas is eliminated•The system can be deployed flexibly and is cost-effective compared with oxy-acetylene.•Control over the combustion process will enable reducing or oxidising conditions to prevail during the heating process.The aim is to develop and validate the use of oxy-hydrogen combustion as an alternative to oxy-acetylene, for applications which could include precision welding, brazing and soldering, cutting, repair and heat treatment.The project will involve the specification of the required heating for a given application, different design(s) of electrolyser, the design of heating torc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Listening to change: acoustic monitoring of multi-trophic community dynamics in the face of increasingly variable and extreme environmental conditions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Species are often predicted to lag behind the unprecedented pace of ecological changes imposed by current human activities. Such changes result not only in modification of the mean environmental values in an ecosystem but also in increasingly extreme and variable environmental conditions. These extreme and variable conditions operate at fine spatio-temporal scales. A mechanistic understanding of these dynamics in response to new environmental conditions thus requires monitoring, analysing and modelling at such fine spatio-temporal resolution. Passive acoustic monitoring (PAM) is a rapidly growing field of research that allows for an unparalleled temporal resolution and a wide taxonomic diversity of sound producing species in terrestrial and aquatic environments. In this context, I will use PAM to understand fine scale spatio-temporal community dynamics in response to increasingly extreme and variable environmental conditions. For that I plan to develop a methodological and conceptual framework to understand community dynamics at unprecedented spatio-temporal resolution. First, I will use unsupervised learning to characterise acoustic community composition, creating acoustic groups that I will ecologically identify. I will then use these groups to assess spatio-temporal variation of community composition in these environments and their associations using network models. Finally, I will use different change scenarios to investigate the potential impact of these changes on community dynamics. This research will increase our understanding of the importance of extreme and variable environmental conditions in driving community dynamics.


**Keywords:** Ecoacoustics, community ecology, global change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Taking Force Microscopy into the Third Dimension' (3D-FM).

assistant: **Innovation**

I propose to pursue two emerging Force Microscopy techniques that allow measuring structural properties below the surface of the specimen. Whereas Force Microscopy (most commonly known under the name AFM) is usually limited to measuring the surface topography and surface properties of a specimen, I will demonstrate that Force Microscopy can achieve true 3D images of the structure of the cell nucleus. In Ultrasound Force Microscopy, an ultrasound wave is launched from below towards the surface of the specimen. After the sound waves interact with structures beneath the surface of the specimen, the local variations in the amplitude and phase shift of the ultrasonic surface motion is collected by the Force Microscopy tip. Previously, measured 2D maps of the surface response have shown that the surface response is sensitive to structures below the surface. In this project I will employ miniature AFM cantilevers and nanotube tips that I have already developed in my lab. This will allow me to quickly acquire many such 2D maps at a much wider range of ultrasound frequencies and from these 2D maps calculate the full 3D structure below the surface. I expect this technique to have a resolving power better than 10 nm in three dimensions as far as 2 microns below the surface. In parallel I will introduce a major improvement to a technique based on Nuclear Magnetic Resonance (NMR). Magnetic Resonance Force Microscopy measures the interaction of a rotating nuclear spin in the field gradient of a magnetic Force Microscopy tip. However, these forces are so small that they pose an enormous challenge. Miniature cantilevers and nanotube tips, in combination with additional innovations in the detection of the cantilever motion, can overcome this problem. I expect to be able to measure the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced multifunctional forest management in European mountain ranges' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The sustainable provision of ecosystem services (ES) in and from mountain regions is of crucial importance to an array of stakeholders and society in general, going much beyond the interests of particular landowners in the mountain regions themselves. Mountain ecosystems can only continue to provide all these services in a rapidly changing world if a wide array of ES is considered in forest management at local, landscape and regional scales (multi-functionality). The project builds on seven case study regions in major mountain ranges throughout Europe covering a wide range of forest types, socio-economic conditions and cultural contexts and seeks to develop and evaluate strategies for their multifunctional management considering risks and uncertainty due to changing climatic and socio-economic conditions. The project addresses four main ES: timber production, protection against gravitational natural hazards, the role of forests in climate change mitigation via carbon sequestration as well as bioenergy production, and nature conservation and the maintenance of biodiversity. Non-timber forest products, recreation as well as use of forested landscapes by game and livestock species will be dealt with as well. To analyse conflicts and comple¬mentarities among ES from stand to landscape scales, improved models for the assessment and projection of ecosystem services as well as novel planning and decision support tools will be developed together with SMEs and applied in the case study regions. Stakeholder panels in all study regions will inform research activities and contribute to the development of improved mountain forest management approaches. SME partners play a key role in the development of new planning tools. Ultimately, ARANGE will translate project findings on the eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Analysing frozen Foraminifera by Cryostage LA-ICPMS: Neogene CO2, patterns, cycles, and climate sensitivity.'.

assistant: **Concept**

Knowledge of past concentrations of atmospheric carbon dioxide (CO2) has transformed our understanding of earth’s climate: past, present, and future. Ice cores have yielded 800,000 years of high resolution and high precision data, revolutionising Earth system science. Marine sediment records provide the opportunity for highly resolved records of ocean and past ocean pH (and therefore ocean and atmosphere CO2 content) over millions of years by means of the δ11B-pH proxy, but present progress is currently hampered by large sample size requirements and intensive laboratory techniques limiting throughput and applicability. Innovation is therefore required to answer a number of key questions, including: ‘how do spatial variations in ocean carbon flux cause natural climate variability?’, and ‘does climate sensitivity vary with background state?’ By analysing small samples frozen into a blank-free ice puck, ForCry exploits the increased sensitivity of laser ablation δ11B analysis to enable the next generation of past climate data to be recovered. This novel approach allows analyses to be conducted on ≤20 individual plankton representing a ~10–fold reduction in sample size, but while maintaining precision. Additionally, this approach removes costly chemical purification steps and leads to higher throughput which makes high-resolution CO2 reconstructions using the δ11B-pH proxy a viable option to augment and extend the ice core CO2 records. ForCry has 4 objectives: i) to develop this novel technique and optimise the hardware for efficient data collection from carbonates and other archives: ii) to calibrate through culture and field sample collection the δ11B-pH proxy in multiple species of foraminifera: iii) to map ocean pH change in four dimensions using a data inversion model;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eu enlargement and multi-level governance in european regional and environment policies: patterns of learning, adaptation and europeanization among cohesion countries (greece, ireland, portugal) and lessons for new members (hungary, poland)' (ADAPT).

assistant: **Concept**

The research project focuses on facilitating the adaptation process of EU prospective new member states (Poland, Hungary) to the multi-level system of governance in the regional and environment policy areas by conceptualising learning, institutional and policy adaptation within the EU system of governance in the selected policy areas and by drawing lessons from the experience of previous enlargement waves'-Cohesion-countries (Ireland, Portugal, Greece). This main goal of the project is to be achieved: first, by evaluating the impact of Europeanization on the governance structures of the three unitary member states of the EU in the selected policy areas;and second, by utilizing this research outcome in identifying the reforms that Poland and Hungary should undertake to facilitate the adjustment of their public policy structures to the -new- EU environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Role of Dimension in Metric Embedding' under Seventh Framework.

assistant: **Concept**

We are currently witnessing the generation of massive amounts of data that require analysis, particularly in application areas such as computational biology, text mining, networking and web applications.  Many of these computational tasks can be performed efficiently in low dimensional Euclidean space. In this research proposal, I will set out to investigate fundamental questions in the field of metric embedding, which could provide tools and algorithms for handling arbitrary metric data. The dimension of the host space will play a major role, as it is crucial for the efficiency of algorithms in normed spaces and as it enables compact representation. In particular, I plan to investigate questions such as: How well do certain classes of metric spaces embed into Euclidean space of bounded dimension? What are the bounds on dimension reduction, in several normed spaces and for particular subsets of Euclidean space? Of particular interest is the class of metrics known as doubling-metrics; in some sense, these are metrics with low intrinsic dimension. While there has been much research, in several communities, on these metrics, we still do not understand the dimensionality required for embedding these metrics into normed spaces. I plan to achieve better understanding of the above questions by using newly developed embedding techniques, in combination with tools from probability theory and functional analysis.  Answering these questions will enrich the knowledge of the European Mathematics and Computer Science communities and supply its researchers with new tools and insights for developing improved algorithms for various computational tasks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The first ultrasound-compatible cranial prosthesis enabling diagnostic and therapeutic use of ultrasound in brain pathologies' (INTRA).

assistant: **Concept**

260,000 craniotomies are performed each year in Europe and USA to remove brain tumours and treat brain lesions and injuries. The implants used to replace the flap bone are currently made in plastics and titanium mesh, which are not transparent to ultrasounds (US), meaning that US cannot trespass them.  Intelligenza Trasparente is an Italian start-up specialized in biomedical engineering and neurosurgical image-processing which has developed and patented INTRA, the first implantable prosthesis that allows ultrasound (US) to trespass the skull after neurosurgical procedures.INTRA allows to replace MRI scans (the standard brain imaging method) with US scans for the diagnostic follow-up of the brain pathology (in particular) and for assessing the effectiveness of adjuvant cancer therapies, e.g. chemotherapy and radiotherapy. MRI machines and scans are very expensive, and they availability is limited, forcing patients to long waiting lists. US scans have the same imaging efficacy, but are much cheaper, and the machine are available in every hospital. The result is significant savings for National Health Systems.More importantly, INTRA will enable the use of effective treatments of both cancer and neurodegenerative diseases which are currently unavailable for brain due to the skull barrier to ultrasound, like HIFU, and will unleash the full potentiality of ultrasound for opening the Blood Brain Barrier (BBB).The Phase 1 project will be key to define and accurately plan the next certification steps required to commercialize the product (EU mark for medical device and FDA clearance in US). We will also consolidate the business model, precisely assess the expected benefits for the customers, analyse the potential market, and streamline the marketing and distribution strategy.