RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploiting MELanoma disease comPLEXity to address European research training needs in translational cancer systems biology and cancer systems medicine' (MEL-PLEX) under Horizon 2020.

assistant: **Objectives**

Novel treatment options and associated personalised, patient-tailored therapies need to be explored and developed for highly heterogeneous and chemotherapy resistant cancers, such as malignant melanoma. This can only be achieved by industry-academia collaborations in newly emerging, innovative research disciplines such as translational cancer systems biology and systems medicine. These disciplines and the associated European training needs provide the foundation for the MEL-PLEX ETN. MEL-PLEX aims to understand the network-level and multi-scale regulation of disease-relevant signalling in melanoma through a combination of quantitative biomedical and computational research approaches that go significantly beyond the current state-of-the-art. Coordinated by the RCSI Centre for Systems Medicine, MEL-PLEX will train 15 early stage researchers through a highly interdisciplinary and intersectoral research training programme. MEL-PLEX comprises 11 beneficiaries and 7 partner organisations from 11 countries, including European and international leaders in personalised melanoma therapy, melanoma systems biology and cancer systems medicine. MEL-PLEX aims to (i) achieve an unmatched depth of molecular and mechanistic disease understanding, (ii) will exploit this knowledge to develop and validate predictive models for disease progression, prognosis and responsiveness to current and novel (co-)treatment options, and (iii) will provide superior and clinically relevant tools and biomarker signatures for personalising and optimising melanoma treatment. The MEL-PLEX ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans across biology, medicine and mathematics, that can navigate confidently between clinical, aca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Non-Hermitian Transport in Anderson forbidden land' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

This proposal is centered around the recently discovered (by the PI) ground-breaking way of transport in strongly Anderson localized non-Hermitian media. Initially Anderson localization was studied on electrons but it was later realized that photons provide an alternative cleaner route. However, one fundamental problem of photonics is that of inherent material losses. As the paradigm of parity-time symmetric optics indicates, the resolution of this problem is the judicious combination of gain and loss via index engineering. Such non-Hermitian paradigm provides the opportunity to overcome Anderson localization after sixty years by proposing a novel way of transport unique in the complex photonic media, something that is experimentally impossible in condensed matter physics. The key idea is the inclusion of appropriate gain-loss index profiles that allow light to cross the forbidden land of Anderson via sudden jumps, despite the fact that all eigenstates are localized. My proposal is focused on four directions that span out of the main theme of sudden jumps. The first one is the role of openness in the most general case of uncorrelated disorder. A second open question is that of existence of jumps in correlated media that support constant-intensity states. For both questions the maximization of the effect based on wavefront shaping and index engineering is important. A third question is the possibility of topologically protected jumpy transport in disordered topological insulators. Finally, I intend to examine the more difficult and fundamental problem of many-body effects on non-Hermitian jumpy transport. The underlying mathematical framework, is that of non-Hermitian random matrix theory and pseudospectrum, a widely used method in turbulence studies of fluid mechanics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of standardised in vitro methodology for hepatic and renal toxicity testing' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The toxicological evaluation of compounds is essential in human risk assessment. In industrial practice, up to now in vitro methods have made only a minor contribution to this type of routine testing which represents about 20% of all laboratory animal use. Currrent in-vitro models are based either on primary cells which dedifferentiate continuously or on permanent cell lines that have lost various organ-specific cell functions. Thus, e.g. loss of biotransformation of xenobiotics is an inherent limitation of the predictive value of current cell cultures employed for toxicity testing. A recent breakthrough with regard to differentiation of cells in culture is the perifusion methodology where culture media are continuously renewed. Thus, a homeostasis of the cell environment is achieved in contrast to standard static culture conditions where waste products accumulate and nutrients are only intermittently supplied. The new perifusion technology has been shown to facilitate the maintenance of a highly differentiated state of cells. Cellular models based on perifusion also offer the new possibility of repetitive or even continuous exposure of cells to toxins. Therefore, the time has come to develop improved routine in vitro models for toxicity measurement using standardised perifusion technology. Methodologically, the project will be confined to liver and kidney cells. The models established and characterised in the first year will be optimised for assessment of toxicity. Suitable and reliable endpoints of toxicity of relevance to in vivo toxicity testing will be developed in the second year of the project. In parallel an in vivo data base will be established and test compounds selected. The most promising models will be exchanged between the participating groups and prevalid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MetaMaterials antenna for ultra-high field MRI' (M-CUBE).

assistant: **Innovation**

M-Cube aims at changing the paradigm of High-Field MRI and Ultra High-Field antennas to offer a much better insight on the human body and enable earlier detection of diseases. Our main objective is to go beyond the limits of MRI clinical imaging and radically improve spatial and temporal resolutions.  The clinical use of High-field MRI scanners is drastically limited due to the lack of homogeneity and to the Specific Absorption Rate (SAR) of the Radio Frequency (RF) fields associated with the magnetic resonance.The major way to tackle and solve these problems consists in increasing the number of active RF antennas, leading to complex and expensive solutions.  M-Cube solution relies on innovative systems based upon passive metamaterial structures to avoid multiple active elements. These systems are expected to make High-Field MRI fully diagnostically relevant for physicians.To achieve these expectations, M-Cube consortium will develop a disruptive metamaterial antenna technology. This we will able us to tackle both the lack of homogeneity and SAR barriers. Metamaterials are composite structured manmade materials designed to produce effective properties unavailable in nature (e.g. negative optical index). They allow us to tailor electromagnetic waves at will. Thus, the scientifically ambitious idea is to develop antennas based on this unique ability for whole body coil. This technological breakthrough will be validated by preclinical and clinical tests with healthy volunteers. M-Cube gathers an interdisciplinary consortium composed of academic leaders in the field, eight universities, and two promising SMEs. Physicists, medical doctors and industrial actors will work closely all along the implementation of the project to guarantee the success this novel approach, a “patie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '3D Organization of Functionally Conserved Cis-Regulatory Elements' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Embryonic development requires precise spatio-temporal gene expression generating numerous cell types that build the animal body plan. Cell-fate specification and patterning are driven by developmental genes that are often expressed in complex and conserved fashion. Gene expression is precisely modulated by gene regulatory networks (GRNs) constructed through the integration of signalling pathways acting at cis-regulatory elements (CREs). While signalling pathways and GRNs are evolutionary constrained, CREs are poorly conserved at the sequence level, posing the question which cis-regulatory mechanisms facilitate coordinated and conserved gene expression patterns during animal development and evolution. CREs and their target genes are spatially restricted into conserved 3D chromatin structures suggesting a possible link between the less conserved CREs and highly conserved gene expression patterns.In this proposal, I aim to identify CREs that differentially respond to signalling cascades. Novel approaches, such as HiChIP and capture Hi-C, will be applied to decipher the chromatin structure of the associated CREs and their target genes. The application of this approach in two distantly related vertebrate model organisms will allow me to gain insight into genome-wide evolutionary conserved nodes of GRNs controlled by these pathways. Furthermore, detailed analysis of chromatin structures induced by activation or inhibition of signaling cascades will further contribute to understanding of co-dependency and complementarity of genome architecture, cis-regulatory information, and signalling pathways. 3Dcis research will shed light on the mechanisms driving conserved gene expression patterns and common body structures, but also the constraints that different animal lineages have f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mediterranean Activities for Research and Innovation in the Energy sector' to be submitted under Seventh Framework.

assistant: **Abstract**

Research & Innovation cooperation between the EU and MPC areas is a critical factor for the development of a ‘Common Knowledge and Innovation Space’, in order to jointly tackle important global challenges. The ‘Secure, Clean and Efficient Energy’ Societal Challenge is not only an EU’s critical priority towards H2020 for making the transition to a reliable, sustainable and competitive energy system but is also essential for MPC countries due to energy challenges they face especially because of increasingly scarce resources, increasing energy needs and climate change. Current technology innovations and trends on the technology pillars of RES Microgrids, RES Desalination and Energy Efficient interventions in buildings are crucial for tackling the above challenges. MARE project will bring together actors from the whole value chain of innovation (RTOs, Intermediaries, Business Parks, Clusters and SMEs) in order to foster cooperation for bridging the gap between research and innovation in the EUROMED area, towards the three technology pillars. MARE will perform a set of activities which aim to assist the market uptake of research results, improve competencies and mutual learning of organisation from both areas and finally identify fields on potential STI Cooperation between Member States and MPC counties under the H2020 and bi-regional programmes. Emphasis will be given to enhancing the Common Knowledge and Innovation Space between EU and MPC and to supporting partnerships between Member States and MPC countries through market uptake of research results for global competitiveness and reach of new markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cloud Manufacturing and Social Software Based Context Sensitive Product-Service Engineering Environment for Globally Distributed Enterprise', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

To meet requirements of mass customisation, the manufacturers of machines and equipment for production of mass customised products need powerful engineering environments to allow for multi-directional exchange of knowledge between product design, service design and manufacturing, as well as customers and other relevant organisations across the value chain, distributed all over the globe. Specifically they need feedback from their business customers to whom they sell their equipment, as well as from the final-product customers. Cloud Manufacturing (CMfg) provides new possibilities for collaborative design of product-services within such distributed enterprise, easily adaptable to highly dynamically changing conditions under which enterprises are developing and manufacturing their product-services. On the other hand, tremendous experiences in social software solutions offer new opportunities for enterprises to capture and share experienced based knowledge among all actors across the value chain. Such enormous amount of knowledge to be gathered and shared under dynamically changing conditions, with wide spectrum of actors involved, having different expertise and working conditions/cultures, ask for effective context sensitive solutions for knowledge capturing and analysis. The objective of DIVERSITY is to create a new product-service engineering environment based on a combination of CMfg, PDM/PLM and social software, as well as a set of software tools to support real time sharing of knowledge among various actors, from the designer up to the customer, aimed at small and medium sized companies producing machines/equipment for mass product manufacturers. A new methodology for concurrent collaborative product-service design applying lean based product design paradigm will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transethnic Socialism : Minority Experiences of Socialist Activism in Modern Turkey' (TransethnicSocialism), addressing dissemination and exploitation.

assistant: **Impact**

TransethnicSocialism explores the activities of minority socialists and their participation in the labor movements in Modern Turkey from 1923 to present-day. Despite the burgeoning literature on the socio-political history of the Republic of Turkey, a major lacuna is the participation of ethnic minorities in political processes. While the socialist and labor movements constitute a unique field to study this question due to the increased participation of non-ethnic Turks, it has hitherto escaped academic attention and study. To what extent have their ethnic backgrounds influenced their political choices? How have they been othered by the Turkish state, but also their ethno-religious communities due to their political choices? What markers of difference (e.g. gender, class, age, religion) other than their ethnic background intersected to shape their experience? Focusing on Jewish, Armenian and Greek socialists, the project breaks new ground in three ways: (a) it combines sources in the languages of these communities with Turkish ones, creating a unique dialogue of historical evidence reflecting the experience of these individuals; (b) it traces the overlap between the communal, the national, and the international in the political, social, and intellectual composition of their historical experience; and (c) it sheds light upon a little-known subject, namely the contribution of ethnic minorities to socialism in Turkey.


**Keywords:** Ottoman History, History of Modern Turkey, Balkan History, Ethnicity, Class, Socialism, Diversity, Community
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Taking SynOil to the market: Synthetic oil (SynOil) from plastic waste with the molten zinc reactor' (SynOil).

assistant: **Innovation**

In Europe, the US and elsewhere, many municipals are sending more plastic waste to landfill or incineration for lack of other options. This reversal is due to the Dec. 2017 Chinese import ban on plastic waste. Moreover, the regulatory pressure on plastic recycling is increasing: in May 2019 the EU and most other states signed an agreement, which classifies plastic waste as hazardous, greatly reducing the capabilities of EU member states to export plastic waste to the third world and, hence, requiring treatment within the EU. In summary, the burden of dealing with plastic waste will shift back to Europe, the US, Canada and Japan presenting a large, global business opportunity for Composite Recycling Ltd (CRL).Product & value proposition: CRL owns the patent to turn plastics waste into synthetic oil by treatment with molten zinc. This innovation named SynOil delivers highly profitable plastic waste incl. non-recyclable plastics to synthetic oil plants as SynOil is the fastest possible solution to treat plastic wastes due to heat transfer.Target-users of SynOil are plastic waste recyclers, municipals and industrial plastic waste producers worldwide.Market size: Worldwide about 100 SynOil plants are required. The financial returns for an operator are excellent with IRR’s over 25%depending mainly on throughput, but also local market conditions and other factors.The next step in the SynOil project is the demonstrator scale unit – followed by commercialization. The funding requirement for the demonstration stage is between €1.5 and 8.0 million. The higher figure of €8.0 million is for the special case of a commercial plant for large plastic pieces.Company: CRL was founded in 2012 to commercialize our waste tyre and printed circuit boards (PCBs) recycling processes. SynOil – wa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Upgrade kit for improving treatment efficiency and capacity of new and existing waste treatment systems' (ZEOREACTOR).

assistant: **Concept**

Scientific objectives and approach:The R&D programme for zeoReactor project has got 7 Work Packages (A - H) each resulting in key deliverables:The Specification" workpackage (A) provides the users' demands and requirements to be accounted for in the design of the system (B) and the System integration (C). The "Component Development" workpackage (B) provides the approved components of the system, like modified zeolithes, CFD simulated reactor model, control unit and adapted PSA-unit. The "System Integration" workpackage (C) provides ZeoReactor prototype for the use in the partner SMEs process chains, with the selected measurement procedure and reference and standard data implemented into its hard- and software. In the "Lab tests" workpackage (D) the prototype are tested on lab scale to develop an improved and tested prototype. In the "Field tests" workpackage (E) the prototypes are installed and operated in the user SMEs' production lines. The aim is to adapt and optimise the system according to each users' requirements, and to evaluate and assess its functionality under the rough production conditions. In the "Upgrade" workpackage (F) an upgrade kit for existing waste water treatment plants is developed. In the workpackage "Evaluation" (G) provides a tested and upgraded ZeoReactor system. Finally an adapted and optimised demonstration prototype equipped with a Technical Manual, and a marketing strategy is provided.Problems to be solved:The aim of the Urban Waste Water Treatment Directive (UWWT Directive 91/271/EEC) is that by the year 2005 almost all agglomerations in the EU above 2 000 population equivalent (p.e.) should be provided with collecting systems and waste water treatment plants. Taking into account the fact that many small municipalities do not yet have sewa