RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evaluating a new stool based qPCR for diagnosis of tuberculosis in children and people living with HIV' (STOOL4TB) under Horizon Europe.

assistant: **Objectives**

The COVID-19 pandemic had a devastating impact on tuberculosis (TB) control. In 2020, the number of people newly diagnosed with TB decreased by 18% despite a rising global TB burden. Intensified efforts to improve TB case detection are critically needed, especially in populations in whom bacteriological confirmation is suboptimal, such as children and people living with HIV (PLHIV) who have also been disproportionately affected by the pandemic. The need for highly sensitive sputum-free diagnostic tools for TB has never been greater.STool4TB, an EDCTP-2 funded diagnostic trial, began its activities in 2020 shortly after the onset of the COVID-19 pandemic. The study aims to validate a novel quantitative PCR assay utilizing a stool homogenization and DNA isolation method that yields a highly sensitive and specific detection of Mycobacterium tuberculosis. STool4TB is implemented in high TB & HIV burden settings of Mozambique, Eswatini, and Uganda under the hypothesis that it will contribute to narrow the large TB case detection gap by improving TB lab-confirmation rates in children and PLHIV, while proving feasible and acceptable. New evidence suggests that this platform has a higher sensitivity when compared to sputum culture and Xpert Ultra and could have an additive lab-confirmation yield of up to 20%. STool4TB is also evaluating the qPCR platform as a treatment monitoring tool. This assay has the potential to be adapted to a POC diagnostic test which could be easily implemented in decentralized levels of care.Given the impact of the COVID-19 pandemic on TB notifications at the three participating sites and on several STool4TB core activities, we request additional funding to finalize recruitment of participants and achieve the target sample size, ensuring full execution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Taming the reaction dynamics of paramagnetic species' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Radicals are paramagnetic species – atoms or molecules with an unpaired electron – and they are prevalent in gas-phase environments such as the atmosphere, combustion systems and the interstellar medium. In spite of their real-world importance, very few experimental methods can be applied to the precise study of gas-phase radical reactions. This is primarily due to the significant challenges associated with such studies; there are no established methods for generating a pure beam of atomic or molecular gas-phase radicals with tuneable properties. In this proposal, I provide a solution. I will develop a versatile and innovative “magnetic guide”, for the generation of a pure and state-selected beam of radicals. The magnetic guide will feature a series of specially-designed permanent magnets (Halbach arrays) and skimming blades. It will act as a stand-alone device, producing a pure beam of radicals with continuously tuneable velocity from an effusive mixture (containing radicals, precursor molecules and seed gases). The magnetic guide will be combined with two existing experiments – an ion trap and a liquid-surface set-up – and will enable us to study ion-radical and radical-liquid surface interactions with unprecedented control and precision. We will examine important gas-phase reactions involving radicals in isolation (i.e. without competing side reactions) for the first time. Our measurements will provide the missing experimental data needed to improve the accuracy of (for example) complex atmospheric chemistry models – replacing untested predictions from capture theory calculations.


**Keywords:** magnetic guide, ion-radical reactions, ion-liquid surface collisions, instrument development, theoretical method development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PROTECTion against Endocrine Disruptors; Detection, mixtures, health effects, risk assessment and communication.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

PROTECTED aims to develop expertise and protective capabilities against Endocrine Disruptors (EDs). EDs and their mixtures are a modern day health concern leading to failing ecological systems, poor agricultural production and health effects such as obesity, cancer and infertility. While analytical methods have advanced enormously, focus has been mainly on synthetic chemicals, overlooking emerging EDs and real-life multiple substance exposure. A new generation of creative, entrepreneurial and innovative early-stage researchers equipped with skills to assess and understand the real-life risk of complex mixtures of EDs and trained to convert resulting knowledge and ideas into accessible tools and services for the long-term control of potential ED risk is urgently needed. The PROTECTED Innovative Training Network [ITN] proposes a holistic approach by providing 15 individual, personalised research projects with exposure to scientific, innovative and entrepreneurial training mobility across the ITN. The intersectorial network is comprised of 12 training sites at academia, research centres, a bioassay technology SME, a QSAR technology SME, water provider, and animal feed supplier. Together they cover multiple disciplines including analytical science of food, feed, and environment, epidemiology, risk assessment, social science and toxicology. This combined expertise enables a highly focused program for developing novel tools and concepts and training for the detection, analysis and improved risk assessment of EDs, especially mixture effects. Methodology will include emerging technologies; multiplexed analysis, mixture modelling, mechanistic and exposure studies, explants and cell or whole organism bioassays. The project will provide a unique and high level of training for a ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Semiconductor Industry Leading towards Viable Energy Recovery' (SILVER) under Seventh Framework.

assistant: **Objectives**

There is no doubt that ICT, supported by semiconductor technology, can play in using more efficiently energy resources and in allowing the adoption of renewable energy production, care must be taken that the complete life cycle of the envisaged technologies is considered, and that also the energy costs for the production of the critical semiconductor components are minimized. This concept applies also to all industrial sectors, like photovoltaics and solid-state lighting, that are largely based on the same technologies as semiconductor manufacturing. The envisaged “green society” can only be such if based on “green fabs” for the manufacturing of the critical components. The SILVER project targets at the design, development and assessment of innovative and comprehensive approaches to reduce the environmental impact of existing semiconductor manufacturing. The project will focus on the development of innovative solutions for the reduction of water and energy consumption, which will result also in the mitigation of greenhouse effect.The project aims to achieve the result through a sequence of coordinated R&D actions involving facility and equipment development.The path to solution will be:a)Reduction of direct energy consumption through:•control of the idle mode of equipment•equipment and process modelling•optimization of process recipes on plasma equipmentb)Reduction of D.I. water consumption through:•Introduction of new cleaning procedures;•Optimization of water consumption in critical process steps;•Water recycling and re-use.The final objective is to demonstrate new technologies that will enable the participating companies to achieve reduction in water and energy consumption in line with the targets that international organizations are defining for the next period.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Noise control materials', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

NOCOMAT NETWORK OVERVIEW The objective of NOCOMAT Thematic Network is to organise cooperation between professional partners (from academic to end-users) in the field of Noise Control Materials. Much research work has been done over the last two decades to model and predict noise generation in all industrial sectorsmost funded by the EU Programmes. At the same time, very little has been undertaken to improve the understanding of fibrous/porous viscoelastic materials used to Reduce Noise. The same is true for specific materials characterisation, instrumentation and improved end users information. The Network groups eighteen partners covering all major aspects of a more efficiently operative noise control materials related industries, not involved in EU Programmes. They will put their expertise to improve the state of the art, better understand their market and share ongoing research programmes and contribute promoting training and technology transfer. The European Materials industry shall benefit as a whole from the various coordinating activities planed by the NOCOMAT Network for the next three years. EUROPEAN DIMENSION AND PARTNERSHIP The partnership has been selected from a broad list of potentially interested partners, on the basis of actual capability for the required level of involvement and a complementarity in the various objectives of the Network from the scientific and the industrial application point of view. The main industrial manufacturers are located in some of the Member States and their basic products are being used and transformed by a large number of SME's, in all Member States, specializing in specific technologies and special applications. NOCOMAT has a true European dimension objective and the benefits will be shared by industry from all Member State
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Monte-Carlo Determination of Causation in Turbulence', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Simulations have driven many recent scientific advances. In the case of the physics of fluid turbulence, they have involved some of the most expensive computations at any time, but faster computers now permit meaningful simulations to run in minutes in a modest machine. This proposal centres on exploring the role of simulations in this limit of ‘zero’ computing cost, and on the analysis of the resulting data. What ‘free’ simulations allow is ‘Monte-Carlo’ research, in which ideas are ‘randomly’ tested and only evaluated afterwards, in the hope that some of them be fruitful. Their main advantage is to alleviate ‘paradigm lock’, in which radically new ideas are unlikely to get tested and knowledge gets stuck in a local optimum.  But ensembles of cheap simulations also provide causal information about what the effect of a particular ‘random’ initial condition is. The main result in turbulence is expected to be the identification of novel flow structures, with definitions grounded in the underlying physics. Up to now, structures have mostly been described in terms of properties assumed to be important (e.g. intensity), with their effect on the flow being tested a-posteriori, but Monte-Carlo search allows us to reverse the process, identifying structures from their effects. In particular, we will search for flow configurations that are ‘causally most sensitive’ to perturbations, in the sense that the perturbations are most effective when applied to them. Both the probing perturbations and the receptive flow states constitute ‘causes’. The implied definition of causality only applies over times of the order of a turnover, and is connected with control: changing the cause modifies the effect, with obvious applications. The flows examined will mainly be wall-bounded ones, inclu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Differentiation and characterisation of brain-derived extracellular vesicles from the peripheral blood for understanding the neuropathophysiological mechanisms of migraine.' (DiBDEV).

assistant: **Concept**

Migraine is a major disease burden on society but remains poorly understood. The onset of migraine with aura has been linked to cortical spreading depolarisation (CSD) and Professor Turgay Dalkara (the supervisor) found that inducing CSD in animal models led neurons to release inflammatory proteins in extracellular vesicles (EVs). Because brain-derived (BD)EVs cross the blood-brain barrier and their composition reflects their cellular and temporal origin, they represent biomarkers that, if isolated from the peripheral blood of migraine patients, could give an unparalleled insight into cell-specific neuroinflammation in migraine. However, current methods to isolate cell type-specific BDEVs from the blood insufficiently distinguish them from EVs of other tissues, obscuring crucial insights into cell-specific processes. Here, I (Adam Bennett, the researcher) will develop a workflow to isolate cell type-specific BDEVs from the blood of migraine patients then temporally characterise them to gain a cell-type specific molecular signature during migraine with aura. This will firstly involve the optimisation and validation of isolating neuron, astrocyte and microglia EVs (using a panel of specific markers) from the brains and peripheral blood of rats. Secondly, cell type-specific EVs isolated at different time points post-CSD evocation in rats will be characterised using proteomics to generate temporal cell type-specific data on the pathological processes post-CSD. Thirdly, with optimised time points, cell type-specific EVs will be isolated from the blood of patients after migraine with aura onset and characterised. In doing so, I will (1) identify previously unknown biomarkers to deepen our understanding of migraine with aura, with possible treatment derivations; (2) create a t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NANOTECHNOLOGICAL TOOLKITS FOR MULTI-MODAL DISEASE DIAGNOSTICS AND TREATMENT MONITORING' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

NAMDIATREAM will develop a cutting edge nanotechnology-based toolkit for multi-modal detection of biomarkers of most common cancer types and cancer metastases, permitting identification of cells indicative of early disease onset in a high-specificity and throughput format in clinical, laboratory and point-of-care devices. The project is built on the innovative concepts of super-sensitive and highly specific “lab-on-a-bead”, “lab-on-a-chip” and “lab-on-a-wire” nano-devices utilizing photoluminescent, plasmonic, magnetic and non-linear optical properties of nanomaterials. This offers groundbreaking advantages over present technologies in terms of stability, sensitivity, time of analysis, probe multiplexing, assay miniaturisation and reproducibility. The ETP in Nanomedicine documents point out that nanotechnology has yet to deliver practical solutions for the patients and clinicians in their struggle against common, socially and economically important diseases such as cancer. Over 3.2M new cases and 1.7M cancer-related deaths are registered in Europe every year, largely because diagnostic methods have an insufficient level of sensitivity, limiting their potential for early disease identification. We will deliver •Photoluminescent nanoparticle-based reagents and diagnostic chips for high throughput early diagnosis of cancer and treatment efficiency assessment •Nanocrystals enabling plasmon-optical and nonlinear optical monitoring of molecular receptors within body fluids or on the surface of cancer cell •Multi-Parameter screening of cancer biomarkers in diagnostic material implementing segmented magnetic nanowires •Validation of nano-tools for early diagnosis and highly improved specificity in cancer research. •OECD-compliant nanomaterials with improved stability, signal st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ORGANO-CASCADE CATALYSIS: A SHORTCUT TO STEREOCHEMICAL AND MOLECULAR COMPLEXITY' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

To impact science and society in the way that we feel is possible, synthetic chemistry needs to combine innovation and execution. We are motivated by the idea that novel chemical methodologies are needed to enable the synthesis of novel, previously elusive natural-like scaffolds. Only innovative organic chemistry research can provide the next generation of problem solvers.The goal of the ORGANO-CAS CAT research project proposed here is to exploit the potential of Asymmetric Organocatalysis (which involves only organic elements in the active principle) to find cost-effective, environmentally benign, and sustainable synthetic methods for reproducing the rich structural diversity and complexity of natural molecules. This is in line with the European approach of attaining Sustainable Chemistry (SusChem).Recently, we demonstrated the potential of organocascade catalysis to recreate the intricate structural scaffold and related complex stereochemistry of natural-like compounds with very high fidelity. We want to further innovate around the development of novel organocascade strategies for rapidly converting simple achiral starting materials into complex compounds embodying features of natural molecules. We recognized as a necessary step the identification of novel reactivity concepts to enable the inclusion of unprecedented transformations into elaborate yet experimentally simple organocascade reactions. Specifically we will focus on the development of organocatalytic cascade reaction driven by dynamic kinetic resolution as well as on the inclusion of dienamine activation step within the cascade sequence. In the longer term, organocascade catalysis could become the ideal synthetic starting point for assembling libraries comprising enantiopure molecules, which will increase th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'EU-MED Cooperation to foster Innovation and Exploitation in the Agro-Food Domain'.

assistant: **Objectives**

CINEA brings together leading research organisations, industry associations and innovation players from the EU and the MED region to bridge the existing gap between research and innovation in the area of food and agriculture research (societal challange 2: food safety, sustainble agriculture). The ultimate goal is to facilitate the transfer of scientific knowledge to industries and public services and bi-regional cooperation between all stakeholders along the knowledge value chain in the agro-food domain, thus contributing to meeting European and national/regional sustainable development goals. This will be achieved through• SWOT analysis of bi-regional R2I cooperation in the field of food and agriculture research with the feedback to policy level;• Direct brokerage between research, public services and industry players in the agro-food area;• Implementation of the CINEA innovation capacity building training programme• Preparation of the set of pilot technology transfer projects involving European and Mediterranean research performers and users• Creation of sustainable innovation support services – CINEA's Central R2I Helpdesk• Building synergies with other relevant initiatives in the region.The project builds on the fundamental of previous RTD cooperation capacity building initiatives (e.g. INCO ERA-WIDE projects MAP2ERA, FAWIRA, WATEREUS-MED) and involves leading Mediterranean research entities (INRAA, CBS, USF, USMBA), industry associations/ innovation support agencies (API, CGEM, ANVREDET). On the European side the consortium includes exemplarily innovative research organisations (CNRS) and technology providers (CENTA), and relevant expert organizations and facilitators in the field of innovation and technology transfer (UAGF, GIRAF).