RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development, optimisation and implementation of artificial intelligence methods for real world data analyses in regulatory decision-making and health technology assessment along the product lifecycle' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Real-world evidence derived from real-world data (RWD) has a promising role to inform regulatory decision-making. Based on highly relevant use cases from regulatory practice and across the product lifecycle Real4Reg develops AI-based data-driven methods and tools for the assessment of medicinal products. Findings will inform training activities on good practice examples and will be implemented in existing and emerging guidelines for both health regulatory authorities and health technology assessment (HTA) bodies across Europe. There is urgent need to enable the use and establish the value of the application of RWD across the spectrum of regulatory use cases. The use of RWD is established in regulatory processes such as safety monitoring, but evidentiary value for further use cases, especially in the pre-authorisation and evaluation phase of medicinal products, is rudimentary. The use of RWD in post-authorisation steps is constrained by data variability and by challenges in analysing data from different settings and sources. Thus, the development of new and optimised methods for RWD analyses is essential. Real4Reg addresses the challenges and opportunities of RWD analyses across different health care systems by involving multiple stakeholders to work together in a collaborative approach, also outreaching to already established European initiatives. Our consortium assembles partners with outstanding excellence in the field of RWD analyses, including experts from regulatory agencies/ HTA (BfArM, DKMA, Infarmed), academia (Fraunhofer, UEF, CSC, AU) and patient organisations (EUpALS, EIWH). In an advisory board stakeholders provide input and guidance to the project, including patients, industry, payers, HTA bodies and healthcare professionals. The structure and approach of o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GemciTest: An innovative In Vitro Diagnostic for the decision-making process of pancreatic cancer treatment' (ImOPac).

assistant: **Innovation**

Acobiom is a French Biotech SME (SAS, 8 employees). Since its foundation, June 1999, Acobiom has always been at the forefront of medical innovation, in particular in biomarker discovery and diagnostic development, thanks to its expertise and knowledge in genomics, transcriptomics, bioinformatics, and data science. In 2011, Acobiom began working to address the problem of pancreatic cancer.Pancreatic cancer is currently the 4th leading cause of cancer death in Western Countries. If no action is taken, it will rise to be second in 2020. For nearly 80% of patients (~51K and ~150K in USA and EU patients in 2017), diagnosis occurs at an advanced, non-surgical stage, making them incurable. The high mortality rate, with more than 95% of patients dead at 5 years, versus 13% for breast cancer, is partly due to the difficulty to diagnose, but also because of the lack of stratification of patients and a limited choice for treatments in the current decision-making process. There are currently three major chemotherapy regimens for the pancreatic cancer, and up until now, the decisional algorithm in metastatic pancreatic ductal adenocarcinoma (PDAC) management does not mention pharmacogenomics biomarkers, needed to stratify patient populations and to choose the best treatment with the best clinical effectiveness for a given patient. These regimens have very different toxicities profiles which factors in to which regimen is recommended. Through ImOPac project, Acobiom aims to implement an innovative approach to improve personalized pancreatic cancer management in the decision-making process of PDAC, by using biomarkers to help in the patient stratification. This approach is the GemciTest, a non-invasive test based on an 11-gene blood signature score.Thanks to this innovation, Acobiom h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INDENICA - Engineering Virtual Domain-Specific Service Platforms' to be submitted under Seventh Framework.

assistant: **Abstract**

Service-oriented computing has attracted significant attention over recent years. While this innovative approach provides enormous potential for software development in an open, networked environment, the very different constraints and quality concerns in different domains have so far led to a heterogeneous landscape of service platforms.While a single integrated platform would be highly desirable, the domain-specific constraints in areas like factory automation, business information systems or telecommunication are much too diverse, leading to the need for specialized, domain-specific service platforms. Already now a plethora of different service platforms are available. This fragmentation, however, effectively slows the emergence of a full service ecosystem. In order to fulfill the vision of an integrated platform ecosystem, the various platforms must be made interoperable.<br/>The INDENICA project will address these challenges in an explicit and integrated way. It will provide a development method, infrastructure components and tools that support the efficient derivation of specialized, domain-specific service platforms. By deriving these platforms from common infrastructures, we will combine optimal adaptation of the service platform to domain-specific constraints with easy and fast development. At the same time, the resulting platforms will be interoperable by design. This allows integrating arbitrary INDENICA service platforms at any time into a virtual domain-specific service platform. The integrated platforms will act from an application point of view as a single platform, enabling transparent multi-platform deployment and comprehensive QoS management. On the technical side INDENICA will use Product Line Techniques (compositional and generative techniques) to pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Comparative analysis of plant and mammalian DNA methylation functions in epigenetic Arabidopsis mutants' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

BACKGROUND: Epigenetic modifications dictate major biological processes, such as control of gene activity during development and genome stability under stress. DNA methylation is a primary epigenetic mechanism mediated by a family of methyltransferase enzymes. Maintenance function of DNA methylation is well conserved among plants and animals, based on the structural similarity of their methylation proteins. In contrast to plants, however, mammals do not tolerate loss of methylation, making it difficult to study. The model plant Arabidopsis offers a powerful test system for plant and mammalian methylation, because its methylation mutants are viable and fertile, and methylation patterns are not erased via developmental demethylation/remethylation cycles. Plants experience more extreme environment than mammals, and the evolution of plant methyltransferases may have favoured improved stress adaptation, while in mammals, it may lead to more stable establishment and resetting phases during development.OBJECTIVES: 1) To exploit Arabidopsis as an experimental system for mammalian epigenetic studies; 2) to elucidate the evolution of epigenetic diversity by defining differences and conserved function of plant and mammalian methylation regulators; 3) to assess how methylation affects plant stress adaptation.METHODOLOGY: Re-methylation efficiency in methylation mutants and prevention of methylation loss in plants by mammalian transgenes will be tested by bisulphite sequencing and chromatin immunoprecipitation. Hybrid constructs between the plant and animal proteins will be used. Methylation mutants will be exposed to abiotic variables to compare their stress adaptability. EXPECTED RESULTS: To develop Arabidopsis as a model system for mammals, which may improve application of epigen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigating the role of OPN-CD44 in mechanosensitive tumour invasion using biomimetic models' (OPN-Can) targeting Horizon 2020.

assistant: **Abstract**

New fields are rapidly emerging that provide exciting and unforeseen opportunities to target disease. This is especially relevant for difficult-to-treat tumours where, despite decades of promising research, successful clinical translation of therapeutic options remains intractable. The interrelated fields of mechanobiology and biomimetic engineered disease models have come to the fore in the last decade1–3 and provide a range of opportunities to investigate therapeutic modalities4. These fields have implications for cancer research in three major aspects: 1) dissection of the cell biology governing microenvironmental sensing; 2) development of biomimetic platforms that enhance both the relevance (accuracy) of experimental models and our understanding of tumour biology, especially at the level of microenvironment and cell signalling; and 3) creation of analysis tools to quantify cell sensing. In this MSCA Global Fellowship, I propose a formative advanced research training period at one of the world’s leading institutions of cell and molecular biology and bioengineering (UCB) to learn and apply state-of-the-art biomimetic platforms for a novel tumour biology research project investigating osteopontin(OPN)-CD44 in mechanosensitive glioblastoma invasion. This interdisciplinary collaboration will match the expertise of UCB in biomimetic tumour invasion modelling of the biomechanical and biochemical properties of glioblastoma with my expertise in matricellular biology developed through my prior postdoctoral studies of osteopontin in liver disease. On my return to Europe at KCL, this will provide a springboard to establish an innovative independent research program in promising and underinvestigated tumour biology. I will transfer the knowledge learned at UCB to establish to i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Hybrid Quantum Nano-Optomechanics'.

assistant: **Innovation**

The chief endeavor of the project is to develop, investigate and exploit systems associating nanoscale mechanical resonators with single quantum objects. Such combinations belong in the category of so-called “hybrid nanomechanical systems” which constitutes a rapidly expanding field in modern quantum- and nanophysics.The benefit of exploring hybrid systems is manifold. From a practical point of view, due to their size, nanoresonators are extremely sensitive to external forces.  If associated with a high resolution optical sensor through which the nanoresonator can be non-invasively probed and manipulated, the hybrid system holds promise to act as an ultrasensitive force probe. On a more fundamental level, unexplored quantum regimes become within reach, where the interface between quantum objects and mechanical systems can be thoroughly investigated.  From a conceptual point of view, such experiments are of paramount importance as they could reveal the quantum behavior of macroscopic objects.To accommodate these ideas, I propose to develop and investigate two types of hybrid systems. The first one consists of a single nitrogen-vacancy (NV) defect hosted in a diamond nanocrystal, positioned at the extremity of a nanowire. My team and I recently demonstrated magnetic coupling of the NV spin to the resonator position and thereby evidenced the feasibility of realizing such a quantum to mechanical interface.  This novel system can readily be improved to meet the severe requirements of the quantum opto-mechanical experiments envisioned in this project. The second approach also exploits a NV centre, but this time as an integrated part of a diamond resonator. This monolithic system potentially offers an unprecedented coupling, a supreme overall stability, and NV centres with imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PROmoting integrity in the use of RESearch results'.

assistant: **Objectives**

Delivering Responsible Research and Innovation (RRI) requires researchers and research agencies to balance many political, institutional and professional contradictions and constraints. These are as difficult and demanding in non-medical fields as in biomedical research. Researchers, reviewers, regulators and policymakers are tested by the diverse codes of ethical practice and regulations, by the complexities of relevant data protection legislation, by inconsistencies in the applications of regulations and by the practical professional pressures of acting in diverse non-medical research fields. To use research effectively policy makers need to trust in the validity and reliability of research findings. PRO-RES will address these constraints by delivering a supported guidance framework that is comprehensive, flexible and durable, covers the spectrum of non-medical sciences and offers practical solutions for all stakeholders that will comply with the highest standards of research ethics and integrity. This framework will take into account previous examples of good work and best practice, and drive to deliver a set of pragmatic solutions building on previous work and creating strong links with ongoing projects. In terms of post-2020 European strategic funding policy this will offer a strong and sustainable contribution to RRI via a comprehensive ethics and integrity framework similar to Oviedo/Helsinki which will have been constructed in negotiation with relevant stakeholders and so will be acceptable to and accessible by all stakeholders. The proposed set of solutions will promote an ethics framework for research and innovation, help promote more responsible research engagements and enable policymakers to make more effective use of non-medical scientific research informat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Concerted action on tradeable permits (CATEP)' (CATEP) targeting Fifth Framework.

assistant: **Abstract**

A Concerted Action on emissions trading is proposed so as to bridge the gap between Europe and the US in integrating emissions trading into global climate change policy. The Kyoto Protocol allows such trading of greenhouse gas emissions across national frontiers as a means of complying with agreed national quota limits. A series of workshops on key issues will be held, including supplementary, monitoring and enforcement, trading mechanisms and rules, quota allocation, competitiveness issues and linkage with other instruments. National experiences will be discussed in two country forums. Outputs will include a series of Policy Briefs, designed to be user friendly and a web site with workshop papers and policy readily accessible. This Concerted Action will involve key researchers and those in the policy process at various levels in Europe, drawing on expertise from outside Europe when appropriate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ultrafast Laplace NMR' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Laplace NMR (LNMR), comprising diffusion and relaxation NMR experiments, provides detailed information on the dynamics and chemical resolution of molecular systems, which is complementary to NMR spectra. Similarly to the traditional NMR spectroscopy, the information content of LNMR can be significantly enhanced by a multidimensional approach. The long experiment time and low sensitivity restrict the applicability of the multidimensional method, however. Based on spatial encoding of multidimensional data, we develop a broad range of single-scan LNMR experiments, constituting a new class of NMR experiments called ultrafast multidimensional LNMR. The method shortens the experiment time by one to three orders of magnitude as compared to the conventional method, offering unprecedented opportunity to study fast processes in real time. Furthermore, it enables boosting the sensitivity by several orders of magnitude by using nuclear spin hyperpolarization, which allows investigation of low-concentration samples. Ultrafast LNMR opens paradigm-breaking prospects in chemical, biochemical, geologic, archaeologic and medical analysis. LNMR can, e.g., provide unique information on the intra- and extracellular metabolic processes, including those of cancer cells, which facilitates diagnostics and helps to find efficient treatments, and it can be exploited in the development of new types of biosensors. Furthermore, the method reveals previously unobservable details about the phase behaviour of ionic liquids, gel and polymer formation, as well as catalysis, which are essential in understanding their performance in technological applications. LNMR is also applicable to portable, single-sided magnets, implying potential to raise the sensitivity of low-field NMR to a completely new level. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening International Dimension of Euro-Argo Research Infrastructure' (SIDERI).

assistant: **Concept**

The objective of this project is to strengthen the links and integration of the Euro-Argo European research infrastructure into the Argo International strategy of global ocean observations, and to seek participation by, and to develop cooperation with, potential participants in the European neighbouring areas which have a maritime interest.The following activities are planned:-Work on the evolution of the Argo core mission together with international partners (O2, bio-geochemical sensors, deep floats, extension to polar and marginal seas),-Work on the evolution of the Argo data centers (Delayed Mode Quality Control of the North Atlantic ARC and Southern Ocean Argo Regional Center) and role of the European components,-Refine the float deployment strategy in Europe and international seas and links with international partners,-making the interfaces with JCOMMOPS and Argo information center (AIC),-working on legal aspects and policy issues (law of the sea),-Organize scientific and thematic  (regional) workshops open to international partnersThis project will be carried by the Euro-Argo preparatory phase project partners that will form the  future partners of the Euro-Argo ERIC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Digital holography for 3D and 4D real-world objects' capture, processing, and display' in the context of a Seventh Framework call.

assistant: **Objectives**

Current and newly-developed 3D displays have the disadvantage that they either force the user to wear special eyewear, limit the number of simultaneous viewers, discard completely certain depth cues (such as blurring) thus causing fatigue, or else encode only a small number of distinct different views of the 3D scene. It is universally accepted that there is only one known family of techniques that can capture a full 3D scene in a single shot, including phase information, and re-project that light field perfectly thus overcoming all of the above disadvantages: the broad family of holography techniques. All other techniques are only 3D under a whole host of conditions.\tUnfortunately, holograms are not dynamic. By replacing the conventional holographic plate with a digital camera and an optoelectronic 2D screen, we can capture and display holographic video. However, the full implications of bringing a digital version of holography into the world of 3D video acquisition and 3D display, or how effective it would be, are as yet unknown. The 3D information encoded in digital holograms has not yet been fully exploited.\tWe will work towards eliminating the current obstacles in achieving the world's first fully functional 3D video capture and display paradigm for unrestricted viewing of real-world objects that employs all real 3D principles, hence our acronym Real 3D." Our outputs will include functional models of four digital holographic 3D capture, processing, and display scenarios encompassing (i) the full 360 degrees of perspectives of reflective macroscopic 3D scenes, (ii) microscopic reflective 3D scenes, (iii) transmissive or partially transmissive microscopic 3D scenes, and (iv) capture of 3D scenes at infra-red wavelengths."