RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Prognostic assessment of valvular aortic disease treatment coupling Immunological and biomechanical profiles' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Aortic valve diseases are degenerative conditions that develop progressively and insidiously. Once symptoms become evident, life expectancy is significantly reduced. While treatments for these pathologies are widely available, there remains a remarkably high rate of procedural complications. These complications have been shown to have a negative impact on cardiac mortality and the likelihood of rehospitalization for heart failure. This underscores the need for further technological advancements. Protego's objective is to determine whether a combination of immunological and biomechanical profiles in patients with aortic valve diseases can effectively predict post-treatment prognosis. My goal is to develop an innovative, validated, and clinically applicable methodology that can identify the best treatment options and predict post-procedural outcomes while minimizing complications. This methodology will serve to determine the timing of treatment for patients with valvular aortic diseases and assess whether the proposed treatment is likely to be beneficial preoperatively, while also minimizing the risk of post-procedural complications. I will achieve this by combining imaging analysis, deep learning algorithms, in silico models, and in vitro tests. My approach involves the following key objectives: (i) creating a multi-physics digital twin of patients with aortic valve diseases, (ii) developing a validated, high-fidelity model for treatment with quantification of post-treatment outcomes and (iii) generating a proof of concept for a clinically applicable predictive model trained using both immunological profiles and biomechanical features of patients. This innovative approach will provide a deeper understanding of how clinical and biomechanical outcomes correlate with the am
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Eps hep-2003'.

assistant: **Innovation**

The High Energy Physics (HEP) conference of the European Physical society is the major biannual international event of this research field. With the Int. Conference on High Energy and Particle Physics of International Union for Pure and Applied Physics (IUPAP), held in alternating years, it is the focal place of presenting outstanding experimental and theoretical achievements of the field. European researchers are invited to the conference upon nomination of national contact persons. Non-European (non-EPS member state) physicists can be invited by the organizing committee. The organizers encourage the participation of young pre- and postdoctoral researchers: About one third of the participants, especially from experimental groups belong to the young researcher category. To ensure their proper representation determining the scope of the meeting, the conference is divided into two parts: parallel sessions (3 days), dominated by presentations of young researchers followed by 3 days of plenary sessions. Conveners of parallel sessions and keynote speakers are selected by the International Organizing Committee, which coincides with the HEPP Committee of EPS. The Committee is advised by an International Advisory Committee composed of all directors of the major high-energy laboratories in the world, as well as leading theoreticians. The Conference also provides the forum for the award of several prizes. First of all the prestigious High Energy Physic Prize of the EPS will be given to scientists who made a fundamental contribution to the field. Furthermore two prizes especially four young researchers have been created, and successful work in transmitting scientific results to the public is honoured by an outreach prize.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NoE FlexNet - Network of Excellence for building up Knowledge for improved Systems Integration for Flexible Organic and Large Area Electronics (FOLAE) and its exploitation' (FOLAE) targeting Seventh Framework.

assistant: **Abstract**

In the NoE FlexNet, 17 participants from eleven European countries work together in order to support Europe in becoming a world leader in Flexible, Organic and Large Area Electronics (FOLAE). FlexNet aims at interlinking Europe's FOLAE-expertise in the domains of science, technology development, components, devices and systems integration technologies. A special emphasis will be set on the subsequent commercial exploitation of FOLAE-based systems knowledge especially through SMEs, in order to enable a wide spread of FOLAE-based future business in Europe.<br/>The NoE FlexNet will support the integration process of the scientific excellence of FOLAE-oriented European research on Materials, Devices and Systems. This part is complementary to the NoE PolyNet efforts. In addition, FlexNet will integrate excellent scientific capacities from Southern and Eastern Europe.<br/>FlexNet partners have identified the organic transistor as the most crucial building block in order to realised integrated organic systems. Therefore, the scientific focus of the NoE FlexNet will be set on the application of FOLAE-specific organic semiconductors as well as supporting materials for OTFTs including research on interface properties, barrier materials, characterisation, and OTFT device integration into systems. Further topics of dedicated attention and activity will be devices characterisation, systems integration, modelling and design of systems, and manufacturing processes for systems.<br/>Accordingly, NoE FlexNet will be structured in three platforms:- A platform FOLAE Materials and Devices Integration,- A platform Systems Integration and- A platform Knowledge, Dissemination and Transfer to industry<br/>The knowledge associated to these topics will actively be made available to European stake
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Recognition of hemi-methylated DNA by UHRF1'.

assistant: **Innovation**

Cytosine methylation of CpG dinucleotide sequence is an epigenetic mark on the DNA that regulates gene expression, chromatin structure, and genome stability. Patterns of DNA methylation propagate with fidelity greater than 99% and their stable inheritance for more than 80 cell divisions. This robustness is essential as evidenced by the observation that cancer cells commonly exhibit aberrant methylation patterns. Inheritance and maintenance of methylation patterns are mediated by Dnmt1 during chromosome replication and repair. A crucial step in this process is the ability to distinguish hemi-methylated from either unmethylated or symmetrically di-methylated CpG sequences. Recently, it was shown that the protein UHRF1 recruits Dnmt1 to hemi-methylated CpG sites. The interaction between UHRF1 and hemi-methylated DNA involves the flipping of the methylcytosine out of the DNA helix as revealed by three different crystal structures. Using molecular dynamics simulations, the proposed research is aimed at answering the following questions: (I) What is the energetic basis that allows UHRF1 to discriminate between binding to hemi-methylated DNA versus binding to unmethylated or symmetrically di-methylated DNA? In particular, a disfavored binding to unmethylated DNA can arise due to a cavity at the location of the 'missing' methyl group. Half of the atoms surrounding this cavity are hydrophilic with potential of forming hydrogen bonds. Whether this space is taken up by a water molecule or whether it is 'dry' and the consequences on the UHRF1-DNA binding constant, will be investigated. (II) What is the flip-out mechanism of hemi-methylated methylcytosine? Does UHRF1 play an active role in the flipping event? The process of methylating the target cytosine on the complementary strand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A quantum approach to symbolic dynamics' under Horizon Europe.

assistant: **Concept**

This project in pure mathematics aims to solve problems in symbolic dynamics (a mature branch of dynamics with important connections to coding theory, information theory, and operator algebras) using tools from the modern theories of quantum information and quantum groups. The central challenge dating back to at least the 1970s is to classify symbolic dynamical systems. My proposal pioneers a highly interdisciplinary and novel approach using the uniquely quantum phenomena of entanglement and noncommutativity as they appear in quantum information/quantum groups. The main objective is therefore to establish a fruitful connection between symbolic dynamics, quantum information theory and quantum groups to the benefit of all three communities.The proposal is based around two central open problems: how do we classify symbolic systems, and what are the symmetries of symbolic systems? A novel approach to these problems builds on the recent advances made in part by the supervisor that connect graph theory with quantum information/quantum groups. I introduce a new nonlocal game (the Conjugacy Game) that will define quantum conjugacies, and a notion of quantum automorphism that will define quantum symmetries of symbolic systems. This marks the first interaction between quantum information/quantum groups and symbolic dynamics. The ideas are therefore very timely, will have high impact, and set a precedent for future uses of quantum mathematics in other domains and specifically other classes of dynamics (e.g. multidimensional subshifts and algebraic actions).The fellowship will strengthen my academic career via the opportunity to learn new tools in quantum mathematics and apply them to solve important problems in dynamics. It will also allow me to establish new collaborations with l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Operator Algebras that One Can See' (2021-2027).

assistant: **Innovation**

Graph C*-algebras are analytical objects blessed with a tangible structure and classification theory derived from their combinatorial origins. Through the analysis of directed graphs, including higher-rank graphs or quantum graphs, one can visualize and explore them in intuitive ways lacking elsewhere. They serve as strikingly efficient models for key open problems in noncommutative geometry and topology, as well as in C*-dynamical systems. They also provide a focal point for the much-needed extension of the celebrated Elliott classification program to non-simple C*-algebras. The main objective of the project is to achieve a critical mass for a successful attack on these problems by combining the weight of strong research groups inside and outside the EU, using graph algebras as a unifying vehicle for hitherto unconnected areas of mathematics. The synergy of these new and innovative connections should allow us to develop and apply brand new methods unavailable otherwise. Furthermore, researchers using graph C*-algebras for applications in adjacent fields are likely to provide groundbreaking insights making impact way beyond graph algebras themselves. In particular, we expect to develop an interdisciplinary dimension involving quantum computing.We aim to achieve our objective through networking and transfer of knowledge. Between twenty six partners from the EU and North America participating in the network, there are worldwide leading scientific centers. Among about seventy researchers involved in the project, there are famous experts and extremely efficient mentors of young researchers. Combining them with student members of the network yields a top human-resource infrastructure. An important objective is to take advantage of that potential by creating new career opport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Rapid evolution and geographic ranges: predicting marine species persistence and distribution in a changing ocean'.

assistant: **Concept**

In marine ectotherms, the breadth of physiological tolerance largely determines species’ geographical distribution and extinction risk. Understanding the mechanisms underlying environmental tolerance windows and their relation to life history and demography is thus required for predicting taxa sensitivity to global changes more accurately. Specifically, it is imperative to acquire a firm understanding of both plastic and adaptive responses as rescue mechanisms to prevent species extinction, comparing the effects and costs of these mechanisms among closely related species with different biogeography. I propose to compare the capacity for trans-generational plasticity and rapid adaptation to ocean warming and acidification, in geographically widespread and restricted species as a test for biodiversity evolution under global change. My aims are to (1) define if rapid adaptation to multiple stressors can occur, searching for correlations between plastic/evolutionary responses and the width of species geographic range, (2) reveal potential costs associated with plastic/adaptive responses, and (3) draw projections on species demography, persistence, and biogeography under different global change scenarios. To do this, I have identified an ideal study system for which this information can be gathered in phylogenetically closely-related species with similar ecology, but different biogeography, i.e. eight polychaete species of the genus Ophryotrocha (Dorvilleidae). This ambitious project, which draws from the fields of comparative physiology, ecology, and evolution, relies on an innovative, integrative approach that combines experimental evolution, quantitative genetics, macrophysiology and evolutionary theory. More important, it represents an unprecedented opportunity to produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated Airport Apron Safety Fleet Management' under Seventh Framework.

assistant: **Concept**

One of the main challenges in the apron area is that due to many different companies operating on an airport apron, each company brings in the vehicles and equipment it requires to sustain operation. This causes high levels of congestion in ramp areas, which increases the accident rate and the chances of vehicles and equipment being misused. By gaining telematic data on the running times of the various vehicle categories, detailed real-time statistics can be created. This allows advanced fleet management and effective maintenance planning in “off peak periods” helping to reduce the number of vehicles and equipment which is considered necessary to maintain a high level of service. Actual reports on running times allow a good long term budget planning, by showing how many vehicles or pieces of equipment are actually needed to support daily operations. By monitoring the vehicles unnecessary running times can be avoided, reducing costs and environmental impact. This type of information can lead to considerable savings in investment and daily operational costs, and a reduction in vehicles and equipment required, reducing congestion and enhancing safety in apron areas.Therefore, the proposed project AAS will develop, implement and investigate the implications of a cost and safety beneficial high-tech system for comprehensive monitoring and controlling of all GSE vehicles (GSE = Ground Service Equipment), movements at the apron area. Main aims are: - to identify the user needs by a high level airport expert group - to deliver an advanced fleet management concept by maximising the utilization of GSE vehicles - to enhance techniques for cost efficient passenger and luggage flow and efficiency by automatically passing  information from GSE-vehicles into the RMS - to improve airpo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rapid manufacturing of titanium implants' (RAMATI).

assistant: **Concept**

Due to their complex shape, high dimensional accuracy, good surface finish, and one-of-a-kind production prosthesis are usually manufactured by investment casting. Consequently, the materials used for prosthetic applications have to present a multiplicity of characteristics that are practically impossible to achieve simultaneously. Moreover, casting requires considerable tooling and complex finishing operations and the process often leads to poor quality and significant metal scraping. Also, the large numbe r of manufacturing steps and intensive skilled labour requirements make the process costly and slow. In addition to that, a large number of valuable higher reactivity titanium alloys and higher melting point alloys such as tantalum and zirconium alloys can not be cast altogether. The RAMATI project aims at developing Laser Powder Deposition to the production of biomedicai titanium implants for small size, customised prosthesis, for dental, maxilofacial and cranial reconstruction applications, in a one-per-on e basis, in order to allow exact tailoring of the prosthesis to the clinical requirements. LFFM eliminates the limitations of existing casting processes: (a) single-step process that produces near-net shape parts, the time expenditure and cost associated w ith multiple step fabrication are largely eliminated; (b) no machining is required; (c) being a highly automated process, labour requirements are low; (c) higher material purity are obtained because contamination by tools, machining oils, lubricants, clean ing agents and binders is avoided and part manipulation is reduced to a minimum; (d) no tooling or fixturing is required; (e) manufacturing planning is automatic and easy; (f) the factory footprint, capital investment and human resources required are low; and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Participatory Governance and Institutional Innovation' (PAGANINI) under Sixth Framework.

assistant: **Objectives**

PAGANINI focuses on key areas of FP6 and investigates how participation contributes to problem solving in number of highly contentious fields of EU governance. It looks at dynamic cluster of policy areas concerned with what we call the politics of life": medicine, health, food, energy, environment. Politics of life" refers to dimensions of life that are only to a limited extent under human control - or where the public suspects that there are serious limitations to socio-political control and steering. These areas are strongly connected to normative, moral and value-based factors, such as a sense of responsibility towards non-human nature, future generations and/ozones own body. In these areas traditional mechanisms of governance can be seen to hamper policymaking and much institutional experimentation has been taking place. The research objectives are(1) to analyse how fields of governance related to the "politics of life" constitute a new and particular challenge for citizen participation and the generation of active trust.(2) To illuminate how citizens' participation in key areas of European research and technology policy that are connected to the "politics of life" can be made more effective and appropriate,(3) to investigate the changing role of civic participation in the context of multi-level governance in the EU, and(4) to contribute to institutional re-design in a the emerging European "politics of life. The project takes a case study approach to answer the main research questions: How have traditional institutions reacted to the challenges politics of life"?Which institutional frameworks were created to deal with these policy challenges?How is the public involved in newly emerging participatory governance?Do they provide an increase in democratic legitimac