RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Export free rad-hard microcontroller for space applications'.

assistant: **Objectives**

The MORAL project has two main goals. The first goal is to develop a completely European, ITAR (International Traffic in Arms Regulations) free microcontroller for space applications, focused on small satellites, flight control and payload computers for the purposes of mission control, earth observation, navigation and many other applications. The processor core of the microcontroller is based on a novel IHP Peaktop architecture, including novel, European instruction set. The microcontroller will provide mechanisms for increased reliability and adaptability according to the needs of the space applications. Besides the microcontroller, the required ITAR-free middleware, RTOS (Real Time Operating System) and toolchain will be also avThe MORAL project basically has two objectives. One is to develop a completely European, ITAR (International Traffic in Arms Regulations) free microcontroller for space applications, focused on small satellites, flight control and payload computers for the purposes of mission control, earth observation, navigation and many other applications. The processor core of the microcontroller is based on a novel IHP Peaktop architecture, including novel, European instruction set. The microcontroller will provide mechanisms for increased reliability and adaptability according to the needs of the space applications. Besides the microcontroller, the required ITAR-free middleware, RTOS (Real Time Operating System) and toolchain will be also available. Achievement of TRL 6 is planned. The other goal is to establish a new European company held by the core consortium partners involved in the project, which will target a trans-continental market. This new company, as the last stage of the evolution of the project, will sell the microcontroller and give support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantitative Investigation of  Interspecies Differences in Developmental Tempo' (ALLOCHRONY) targeting Horizon 2020.

assistant: **Abstract**

While the mechanisms of embryonic development are well conserved, the progression speed differs among animal species. The molecular cause of ‘allochrony’, interspecies differences in developmental tempo, remains unclear due to lack of an appropriate experimental model. In vitro differentiation of pluripotent stem cells (PSCs) offers unique opportunities to compare the same cell type among diverse species in a similar condition.  We have previously recapitulated the oscillatory gene expression of the segmentation clock with PSCs, demonstrating ~2 hour and ~5 hour oscillation periods in murine and human induced presomitic mesoderm (PSM) cells, respectively. We have further found that the period difference stems from differential biochemical reaction speeds of HES7, a core segmentation clock gene, between the species: human PSM cells show slower degradation rates of HES7 and longer delays in its production processes than mouse cells.  Here we aim to investigate the deeper origin of developmental allochrony, the molecular mechanism by which human cells exhibit slower biochemical reactions. We will systematically and quantitatively measure the degradation rates and delays to reveal commonalities of the genes that show differential reaction speeds between murine and human cells (Aim 1). In parallel, we will test two working hypotheses that nuclear/cytoplasmic transport rates or metabolic rates might be lower in human cells, which should lead to slower biochemical reactions (Aim 2).  The other objective is to test the universality of the mechanism of allochrony. We will create gastruloids, organoids mimicking early embryogenesis, from PSCs of diverse mammalian species to investigate what cell types, in addition to PSM cells, and what species exhibit the differential biochemica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Home sweet home: investigating Neolithic houses in Britain through the microwear and residue analysis of tools' (HOUSE), addressing dissemination and exploitation.

assistant: **Impact**

The construction of houses is a defining feature of the earliest farming communities in NW Europe, but we have a limited understanding of the role of the house in the development of Neolithic societies. How was the house constituted? How did dwelling in houses alter the composition of daily maintenance tasks? How did these changes effect social reproduction? This project will address these fundamental questions within the context of the British Neolithic. Starting from the premise that areas around houses are spaces defined by activities (cooking, craft activities etc.) the project explores how the house was defined through material practices. This will be achieved by reconstructing the character and spatial arrangement of those practices through the analysis of the tools used to conduct them. Tool use will be investigated by analysing: a) microscopic traces of wear characteristic of using tools on different materials (e.g. wood, bone, hide) b) residues left on tools (e.g. blood, minerals and plant starch).Two case studies have been chosen that include the best-preserved Neolithic houses in Britain: a) the Orkney Islands where multiple settlements have been found with well-preserved stone-built Neolithic houses b) the Late Neolithic settlement at Durrington Walls that once housed the builders of Stonehenge. The case studies include a variety of settlement types (e.g. individual/aggregated, short-term/long-term). The analysis will show whether these different forms of settlements were associated with different ranges of technical activities. Ultimately the research will show how houses were used during their earliest developmental stage.The scientific training that will be offered by the Faculty of Archaeology of Leiden University lies at the heart of this project. The t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High-impedance Superconducting Circuits Enabling Fault-tolerant Quantum Computing by Wideband Microwave Control' (DANCINGFOOL) under Horizon Europe.

assistant: **Objectives**

A physical system implementing a quantum bit (qubit) is never perfectly isolated from an uncontrolled environment. The system dynamics is thus noisy, modifying randomly the qubit state. This phenomenon of decoherence is the main roadblock to build a stable quantum computing platform. In order to mitigate decoherence, quantum error correction employs only a few code states within a much larger informational space, so that noise-induced dynamics can be detected and corrected before the encoded information gets corrupted. Unfortunately, most known protocols require to control dauntingly complex systems, with a degree of coherence currently out of reach.   Our project is to build autonomously error-corrected qubits encoded in high-impedance superconducting circuits. In our protocol, a qubit is encoded in the vast phase-space of the quantum oscillator implemented by each circuit, in the form of Gottesman-Kitaev-Preskill (GKP) states. The novelty is that the GKP states are fully stabilized by a modular dissipation, induced by the coherent tunneling of charges through a stroboscopically biased Josephson junction. The coherence of the encoded qubit is expected to exceed that of existing superconducting qubits by orders of magnitude. Furthermore, we propose to perform protected logical gates between encoded qubits by varying adiabatically the parameters of the modular dissipation, paving the way toward fault-tolerant quantum computing.   The major experimental challenge of our protocol resides in the exquisite level of control needed over a wide band in the microwave range. We propose to address this challenge by developing novel on-chip filters, tunable couplers and isolators based on periodically modulated, high-impedance, transmission lines. These on-chip components would fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening and Energizing EU-Central Asia relations' (SEnECA).

assistant: **Concept**

The relations to Central Asia are an important element of the changing transatlantic and geopolitical setting the EU is currently facing. They are influenced by the role the rest of Asia and other world powers play in the region, which the EU has to take into consideration while focusing on its comparative advantages. The main objectives of SEnECA are to strengthen and energize EU-Central Asia relations by establishing a sustainable, transdisciplinary SEnECA Research Network and the SEnECA Stakeholder Network to link European and Central Asian researchers, policy makers and stakeholders in order to improve research cooperation to develop a common SEnECA Agenda for Future Research Cooperation and EU’s Central Asia policy by setting up the SEnECA Policy Roadmap. The SEnECA Communication Plan for dissemination and awareness-raising will promote the importance of Central Asia to Europe among scholars, policy-makers, stakeholders in education, media, civil society and the EU public sphere notably through the SEnECA Exhibition. SEnECA will thus ultimately strengthen capacities in research and policy advice through the SEnECA Academic Policy Advice Training. Within two years, twelve consortium members from think tanks, universities and NGOs in Europe and Central Asia build on their Trans-European and Central Asian network with research institutions in 41 European, Central Asian and other Asian countries. Through its activities, SEnECA maps existing networks of researchers of Central Asian Studies in Europe and European Studies in Central Asia and key actors in education and media active in EU-Central Asia relations to analyse research cooperation, policies and communication on Central Asia to set up the SEnECA Research Database which forms the basis for recommending priorities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Collective excitations in heavy ion reactions - multiphonon states'.

assistant: **Concept**

Research objectives and content There is disagreement between experimental Coulomb inelastic cross section for Double Giant Dipole Resonance (DGDR ) and standard model calculations. By introducing anharmonicity and non-linearities in the external field and taking into account other double phonon states in the DGDR region the inelastic cross section gets very close to the experimental values. To extend the previous work we want to check within an analytic model the validity of the approximations introduced so far. We want also to include the contribution of the nuclear part, which is important at 50- 100 MeV/A. Furthermore, we want to apply this framework to other systems like deformed nuclei or nuclei far from the stability line. Training content (objective, benefit and expected impact) The scope of the proposal is to enlarge the collaboration by involving people of Nuclear Physics Departrnent in Sevilla who are working in related fields. A long term visit in Sevilla will benefit both the applicant and the Spanish colleagues because in such time | the sharing of the expertise will enlarge the knowledge and the deep understanding of the problems studied. The present proposal links two groups working in less favoured regions: Andalucia and Sicilia. This common project will certainly promote further development in the research activities which they are already carrying on. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Catalystic traps for diesel particulate control' in the context of a Fourth Framework call.

assistant: **Objectives**

- Task1: An oriented engineering model for the prediction of diesel foam filter operation was developed. Back pressure, filtration, particulate accumulation, heat transfer and thermal regeneration models were developed in this study. To validate the models for filter development, experiments were adapted and optimised to validate filtration efficiency and pressure drop models. The second part of the Filter Development study concerns the foam trap structural optimisation. A definition of the composition, an optimisation of the slurry, mechanical tests, an optimisation of the open-pore structure were the different steps to the new recipe definition. Alumina and Mullite toughened by zirconia ceramic foams, with fine porosity, were the best compromise between mechanical and thermal properties;- Task 2: Catalysts investigated were pure metavanadates, binary eutectic mixtures, pure pyrovanadates, and ternary eutectic mixtures. Oxidation and ageing tests, and chemical stability of the catalyst deposit on ceramic foam allowed the partners to select one oxide mixture catalyst as the best compromise for its catalytic activity and its eutectic melting temperature. The deposition procedure was optimised to prepare a number of different shape ceramic foam impregnated with the defined catalyst;- Task 3: Investigation of catalytic foam samples at a lab scale by employing synthetic gas and particulate mixtures as feed gases was carried out. Some engine preliminary tests were performed too. The activity of the studied catalysts, their stabilities, the catalytic foam thermal and mechanical behaviour and its filtration efficiency were assessed. Different configuration of prototypes were considered;- Task 4: After investigation on radial flow design filters, catalysed and un-catalysed, on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Data Infrastructure for Chemical Safety', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The EU nowadays witnesses increasing demands with regard to chemical safety. In particular, animal-based test models need to be replaced preferably by robust, non-animal assays in vitro/in silico which better predict human toxicity in vivo, are less costly, and are socially better acceptable. Consumer's and patient's health will benefit and competitiveness of EU's chemical manufacturing industry will be increased. For developing such assays, FP6/FP7 Research Programmes are exploiting the revenues of data-dense genomics technologies. However, till date, there is no infrastructure foreseen which aims at capturing all data produced by toxicogenomics (TGX) projects, in a standardized, harmonized and sustainable manner. Data may thus evaporate. The lack of such an infrastructure also prevents innovative breakthroughs from meta-analyses of joint databases and systems modeling.Driven by these needs of the TGX research community, diXa will focus on networking activities, for building a web-based, openly accessible and sustainable e-infrastructure for capturing TGX data, and for linking this to available data bases holding chemico/physico/toxicological information, and to data bases on molecular medicine, thus crossing traditional borders between scientific disciplines and reaching out to other research communities. To advance data sharing, diXa will ensure clear communication channels with and deliver commonly agreed core service support to the TGX research community, by providing SOPs for seamless data sharing, and by offering quality assessments and newly developed tools and techniques for data management, all supported by hands-on training. Through its joint research initiative, by using data available from its data infrastructure, diXa will demonstrate the feasibility of it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neuron/mast cell interactions in skin diseases' (NEMESIS).

assistant: **Innovation**

Atopic dermatitis (AD) is a chronic skin inflammatory disease affecting 10-20% of children worldwide. The etiology of AD is incompletely understood, but many elements (e.g., genetic, environmental or immune) are thought to contribute to the pathogenesis. The skin is specifically enriched in mast cells (MCs) and innervated by a network of abundant sensory neurons. New findings suggest that nociceptive sensory neurons (nociceptors) might regulate the development of immune responses. Skin MCs also express a transcriptional signature of genes encoding neuropeptide receptors (e.g., Mrgprb2: the receptor for the substance P [SP]), through which MCs might uniquely interact with nociceptors. Based on solid preliminary data, the central hypothesis of this project is that SP-producing nociceptor/Mrgprb2+ MC interactions play a critical role in AD pathogenesis. Using a relevant mouse model of AD and innovative imaging approaches, we now aim to elucidate [1] which subset(s) of nociceptor is involved in AD, [2] how SP+ nociceptor/Mrgprb2+ MC interact in our model and in skin lesions from patients diagnosed with AD and [3] how such interactions might favor skin barrier dysfunction. This project promises to provide new insights into skin neuro-immune interactions and may lead to the discovery of new therapeutic targets to treat AD pathology.


**Keywords:** NeuroImmunology, Nociceptors, Mast cells, Skin Barrier, Atopic Dermatitis, Allergic disorders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elucidating the impact of the microbiome on adipose tissue immune cell interactions during obesity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Obesity affects hundreds of millions of people worldwide and poses a major burden on global health and economy. Immune cells residing in white adipose tissue (WAT) have recently been highlighted as important factors contributing to metabolic dysfunctions during obesity, which is characterized by chronic low-grade inflammation of fat depots. The yet unresolved interplay between adipocytes and immune cells in the WAT niche represents a major challenge to any rational interference into the metabolic derailments. Likewise, the microbiome has been suggested as a critical mediator of obesity, but the regulatory mechanisms remain elusive.My project aims at a comprehensive assessment of the adipocytes, the adipose tissue immune cells, and their intercellular communication circuits during high-fat diet-induced obesity, as well as the exploration of the impact of the intestinal microbiota on this dynamic process. First, I will characterize adipocytes and immune cells in WAT at the steady state and during obesity of mice by means of single-nuclei RNA-sequencing. Then, I will utilise these transcriptomic profiles for computational modelling to discover disease-specific cell-to-cell interactions, and validate them in signal transduction experiments. This approach together with the analysis of faecal microbiome transplantations into germ-free mice will define the contribution of intestinal microbiota to the WAT remodelling during obesity. By elucidating the impact of commensal bacteria on adipose tissue cell-to-cell interaction networks, my project aims to take a radically new approach in studying the microbiome-adipose tissue axis and its mechanistic contribution to the aetiology of the obesity pandemic. This systems biology approach may lead to a conceptual leap forward in our unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Exploiting the genomes of diverse pseudomonas biocontrol strains for sustainable agriculture, to protect the environment and to improve human health by production of healthy food'.

assistant: **Concept**

Success and sustainability of agriculture in the EU in producing healthy food is highly dependent on the suppression of phytopathogens, which cause major crop losses and decrease the quality of food. Biocontrol forms an environmentally friendly alternative for chemical pesticides, which are often harmful for the environment and human health. Pseudomonas is the most frequently used biocontrol bacterium. To be able to understand biocontrol and to come to an efficient application this project will analyse the genomes of four Pseudomonas strains with different biocontrol mechanisms using functional and comparative analyses. The project focuses on(1) the discovery of novel biocontrol genes,(2) evolutionary aspects of biocontrol mechanisms(3) relationships between Pseudomonas biocontrol strains and the human opportunistic P. aeruginosa PAOl and(4) the development of microarrays for monitoring biocontrol activity in agriculture.