RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultrasound peripheral interface and in-vitro model of human somatosensory system and muscles for motor decoding and restoration of somatic sensations in amputees' (SOMA) under Horizon 2020.

assistant: **Objectives**

The SOMA project tackles three grand challenges in the field of upper-limb neuroprosthetics: a) to develop a completely novel low invasive peripheral interface for restoring natural and multimodal tactile sensations in amputee subjects, with high selectivity and discrimination capabilities thanks to focused UltraSound (US) stimulation, b) to develop and validate an in-vitro model of the innervated natural skin and its sensory receptors, through the application of cutting edge tissue engineering technology and neurocomputational modelling, for the study of spatio-temporal relationships between cutaneous stimuli and afferent neural signals, and for the validation of stimulation techniques of the Peripheral Nervous System (PNS), c) to demonstrate the effectiveness of the newly developed interface through the closed-loop sensori-motor control of an upper-limb prosthesis.The new insights obtained with in-vivo experiments revealed that FUS stimulation does not appear to be a reliable and safe method for constituting a suitable nerve interface for use in humans. Still keeping the ultimate goal of developing a novel solution of peripheral interface with reduced invasiveness, a Hybrid US-electrical stimulation system is being investigated, together with the fallback option of a fully implantable and wireless solution for electrical nerve stimulation. Therefore, the SOMA system will rely on focused US probes for decoding motion intention, implantable wireless technologies for feeding sensory information encoded through new algorithms capable of generating multimodal sensations related to mechanoreceptors (for mechanical pressure), nociceptors (for pain) and thermoreceptors (for changes in temperature). The in-vitro model of the somatosensory system will be composed of a biohybrid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'COMPRESSIVE DATA ACQUISITION AND PROCESSING TECHNIQUES FOR SENSING APPLICATIONS'.

assistant: **Concept**

This is a proposal to support Dr. Ali Cafer Gurbuz’s reintegration as a full-time faculty member at TOBB University of Economics and Technology (ETU) in January 2009, leaving his post-doctoral position at the Georgia Institute of Technology, USA.  Dr. Gurbuz’s expertise is in the areas of signal, image and array processing, with emphasis on radar, subsurface imaging, and compressive sensing.  The technical objective of the proposed research is to develop novel data acquisition and processing techniques for newly emerging compressive sensing systems.  Dr. Gurbuz brings unique experience to ETU as he has collaborated with one of the pioneers of compressive sensing, Dr. Romberg, and has an invention disclosure in the area of compressive wireless sensor networks.  The three-year research plan outlined in this proposal builds upon his expertise acquired over his last six years in the US and continues his successful collaboration with researchers in the US while also ensuring transfer of that knowledge to potential collaborators in Europe.  Our research plan is comprised of three sub-thrusts:  1) compressive remote sensing, with applications to subsurface imaging using GPR and EMI sensors; 2) multi-sensor and distributed compressive sensing; and 3) detection and estimation algorithms based directly on compressive data.  These are timely research projects since compressive sensing is a newly emerging technology, especially in the area of remote sensing, where there are many unexplored areas of research and since initial results have shown its potential in a variety of applications.  ETU is in a good position to lead his project as one of the fastest growing universities in Turkey with modern facilities and a dynamic faculty.  ETU is very confident of Dr. Gurbuz’s potential to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Temporal processing in Drosophila melanogaster' in the context of a Horizon Europe call.

assistant: **Objectives**

All information processing in nervous systems relies on spatial and temporal patterns of neural activity. While spatial patterns are dictated by neuroanatomy, the mechanisms that give rise to temporal activity patterns are diverse. They range from fast voltage dynamics of single neurons at one end of the spectrum to slow transcriptional and structural changes at the other, but the rules that shape signals at timescales in between milliseconds and minutes are poorly understood. The proposed research aims to uncover mechanisms of temporal information processing at these intermediate timescales, at which temporal patterns are thought to emerge from recurrently connected circuits. Detailed insight into the function of these circuits has been limited by the large number of circuit elements, by the lack of knowledge about their connectivity, and by the impracticability of recording from all circuit elements under naturalistic conditions. In Drosophila melanogaster, these limitations no longer apply. The comparatively low number of neurons, their well-mapped connectivity, and our ability to record and control their activities make mechanistic concepts testable. We will focus on three processes in the brain of Drosophila that unfold over three timescales ranging from milliseconds to minutes: 1) temporal filtering in the motion vision system, 2) sequential sampling of motion information in the lead-up to a perceptual judgement, and 3) temporal integration of distance during locomotion. Patch clamp experiments in the smallest of invertebrate neurons in vivo will allow us to record activity at the highest temporal resolution. We will combine this technique with behavioural, genetic, and imaging experiments to test the roles of individual neurons, their biophysical properties, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Plastic Optical Fibre for Pervasive Low-cost Ultra-high capacity Systems' (POF-PLUS).

assistant: **Innovation**

POF-PLUS will develop new components, modify fibre assemblies and optimise transmission techniques to enable high speed (multiple Gbps) optical links based on standard large-core Plastic Optical Fibre (POF) which will take full advantage of the intrinsic low cost and extreme ease of installation of POF based systems to aid both wired and wireless service delivery to end users in next generation networks (NGN). To this end, POF-PLUS will address the following specific tasks:<br/>\toptimization of photonic components  for multi Gbps POF transmitters and receivers, improving their linearity, bandwidth, resilience and reliability<br/>\tdevelopment of PCB-based laser and photodiode arrays suitable for parallel optic solutions using POF<br/>\tdevelopment of new simplex duplex and ribbon POF cable assemblies<br/>\tdevelopment of extremely user-friendly POF connection interfaces and cabling solutions to ensure low installation costs and a viable self-install solution<br/>\tdevelopment and realization of system prototypes at multiple Gbps based on the new optical components and advanced modulation formats and demonstrating the viability of radio-over-POF transport of wireless services<br/><br/>The main target applications envisioned for POF-PLUS outcomes are:<br/>\tnext generation high-speed home networking solutions (wirebound and wireless) with the main focus on 1Gbps solutions;<br/>\tlow-cost optical interconnects in large data centres and storage area networks, where the main focus is on multi-Gbps solutions.<br/><br/>POF's key advantages versus other cabled solutions are its ease of connection and termination, very small cable diameter, low weight and complete immunity to electromagnetic emission making it an ideal solution for those applications where link integrity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'African Regional Capacity Development for Health Systems and Services Research'.

assistant: **Concept**

This project will add new research training capacity at Sub Saharan African (SSA) universities, for health systems and services strengthening. The focus is doctoral and post doctoral training, institutional strengthening for education, financial and administrative research management, and South-South network building. Novel capacity building approaches will reduce brain-drain, be more climate friendly and encourage gender equity with south based training. Internet mounted downloadable modules in quantitative (e.g., epidemiology), qualitative (e.g., anthropology) and economic methods will support excellent interdisciplinary courses. Our EU and African partners have many successful previous collaborations, e.g., web based training modules; joint PhD degree with Uganda. Health systems strengthening is research intensive, incremental improvement to service delivery, implementation and evaluation. Therefore SSA countries need to grow their own health services and systems research (HSSR) capacity: interdisciplinary, rigorous and relevant. ARCADE-HSSR will support evidence informed service delivery by producing a stream of well trained young HSSR scientists, the next generation of health system leaders and researchers in SSA. Activities will be aimed at individuals, institutions and at the network. Makerere University(MU) and Stellenbosch University (SU) are two strong SSA universities  with HSSR focus. They will act as hubs in a South-South network including MU, SU, and initially, Muhimbili (MUH) and Malawi (MA). Working with strong northern HSSR institutions (Karolinska Institute KI, Sussex University Institute for development Studies, IDS, and Norwegian Knowledge Centre for Health Services KS) this region-wide approach will draw skills, resources and students to a new south
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Discovery and molecular investigation of mycobacterial transporters responsible for iron acquisition'.

assistant: **Innovation**

To infect humans, the devastating pathogen Mycobacterium tuberculosis critically depends on two closely related siderophores – soluble carboxymycobactin and membrane-bound mycobactin – which capture iron with high affinity inside the host cell. Despite their undisputed importance for virulence, little is known about how these siderophores are exported and imported across the two mycobacterial membranes.Building on my lab’s experience in elucidating transport processes of pathogenic bacteria, we will unravel the molecular mechanism of an unusual ABC exporter which is thought to import iron-loaded siderophores across the inner mycobacterial membrane and to release iron in the cytoplasm by virtue of its attached siderophore interacting domain. Further, we will investigate two proton-driven transporters responsible for the efflux of empty siderophores, exhibiting an unknown protein fold. We will determine atomic structures by combining X-ray crystallography and cryo-EM and thoroughly investigate active in- and efflux of siderophores in liposomes as well as in cells. Siderophore transport across the outer mycobacterial membrane is a terra incognita. By combining high-density transposon mutagenesis with deep sequencing (Tn-Seq), we aim to discover novel receptors, carriers and channels involved in siderophore transport, which are subsequently characterized at the biochemical and structural level. Siderophore-mediated iron acquisition offers a vulnerable attacking point of M. tuberculosis. Using protein engineering, we will develop a human siderocalin exhibiting low affinity binding for carboxymycobactin into a therapeutic agent able to efficiently capture mycobacterial siderophores and thereby starve M. tuberculosis for iron. In summary, we will discover novel proteins involv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engineering the protein export machinery for the expression of g-protein coupled v1a receptor' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content G-protein coupled receptors (GPCRs) belong to a large family of membrane molecules that play a central role in signal transduction. The large scale production of GPCRs for their structural characterisation has been attempted in various systems like baculovirus infecting insect cells, yeast or bacteria... but scarcely with success. The major problem encountered is the low efficiency of expression of GPCRs at the cell surface. This could be due to an overloading of the protein insertion machinery leading to the accumulation of those proteins inside the cell without being translocated to the plasma membrane. Two main pathways of protein targeting to the membrane are well described in Escherichia coli: the Sec and the SRP pathway. Recent published data suggest that the SRP machinery of E.coli, which is largely studied in the host laboratory, is the main pathway that target membrane proteins to the cell membrane. We will first characterise the targeting and insertion pathway of GPCRs in E.coli. This study will be done with the vasopressin receptor V 1 a, a prototype of GPCR of great interest in the pharmacological industry and which the host laboratory is currently trying to overexpress in E.coli. The second step will be to co-overexpress the Vla receptor and its export machinery, using molecular biology and co-expression systems, to improve the targeting of the Vla receptors at the E.coli membrane. This new strategy of overexpression of GPCRs structural studies will be extended to other membrane receptors. Training content objective, benefit and expected impact)  Due to the importance of GPCRs in a large variety of biological processes and the need for pharmaceutical research of knowing their structural features to discover some new drugs, lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Efficient ice protection Systems and simulation Techniques Of ice Release on propulsive systeMs' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Icing conditions are one of the most severe for aircraft and engines as experienced in the certification process and in-service events. Certification tests are never simple because icing phenomena is a very complex domain and designers have access to a very low level of prediction capability compare to other fields, mainly relying on a very fragmented knowledge based on empirical past experience. With the development of next generations of engines and aircraft, there is a crucial need to better assess and predict icing aspects early in design phases and identify breakthrough technologies for ice protection systems compatible with future architectures.The STORM project will provide new advanced simulation methodologies in three specific fields: ice release, ice accretion with runback aspects and ice trajectory applied for aero propulsive systems to improve the knowledge of engine components behaviour under icing conditions. STORM will also increase the maturity (TRL4) of the most promising innovative technology for Ice protection by developing and testing against selected representative engine & nacelle components, including rotating features. In particular, a step forward in ice phobic coating is a major objective of the project. This research work will greatly contribute to improving cost efficiency for future engines and in developing a higher level of competitiveness in the field of Ice protection systems (IPS).STORM is a 3-year collaborative project comprising 14 research and industrial partners from 7 European countries.STORM has been identified by the WEZARD CSA as a priority research theme within the European R&D roadmap on actions against hazard weather conditions. STORM is also supported by Engines Industries Management Group (EIMG) cluster.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Miniaturized sensor system for continuous soil-nutrient monitoring based on integration of a lab-on-a-chip microfluidic cartridge with an optoelectronic detection unit' (SOILMONITOR) under Horizon Europe.

assistant: **Objectives**

The soil of the earth is the basis of our life. Efficient use of soil is needed for feeding the growing population. Contaminated soil needs to be regenerated to protect the quality of drinking water and more generally the ecosystem. Here, we propose a highly miniaturized sensor system for monitoring nitrate, ammonium, and phosphate based on integration of a lab-on-a-chip microfluidic cartridge with an optoelectronic detection unit. The optoelectronic detection chip employs the directional organic light emitting diode (OLED) we developed within the ERC PoC project BEAMOLED. This kind of OLED allows for direct integration of the optoelectronic chip with the microfluidic cartridge providing a new level of miniaturization of the optical readout measurement system. We propose the use of colorimetric assays based on starting with standard assays and improving performance using nanozyme catalysis. A hydrophilic ceramic as inlet to a microfluidic channel is proposed for intake of soil solution. Reagents as well as the waste are stored in the sensor system. We target a system size of 3 cm x 3 cm x 5 cm for maintenance-free operation in the soil for a duration of one year for in-situ monitoring of 100 data points per nutrient. In a soil-science study the soil-solution extraction into the microfluidic will be investigated for soils with a wide range of pore size distributions, bulk densities, pore-space connectivity, and soil water content to validate the extraction approach scientifically. Pot and field tests in agriculture and soil remediation are planned for validation in application-relevant environments of two potential markets and to develop market readiness. Our aim is to start a spin-off company after completion of this project. By the parallel development of the technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Abradable seal coatings and claddings for compressor applications' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Increasing the efficiency of gas turbine engines has been the subject of continuous investigation and one in which European companies are especially active. Improving the abradable seal between the blade and casing, by reducing tip leakage, is an important area for research which will lead to a substantial improvement in engine efficiency and fuel consumption. The aim of this study is to gain a much better, more fundamental understanding of abradability and at the same time design and produce a new family of powder/coating methods and structures. To aid understanding, a computer simulation model will be developed and validated for abradability and wear against OEM data. The results of this study can be exploited in the highly competitive aero-engine market, power generation gas turbines, pump compressors and engine turbochargers.