RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing Stretchable Conductive Fibres and their Implementations in Wearable Electronics' (Wearonics), addressing dissemination and exploitation.

assistant: **Impact**

Europe needs to take action to develop stretchable conductive materials to lead to the wearable electronics industry, which will be worth over $30 billion dollars in 2020. Although flexible electronics are dominating the current wearonics industry, their applications are restricted due to significant reduction in their conductivity under the applied strain. All stretchable conductors with mechanical compliance materials like human skin are required for epidermal electronic devices and wearable electronics. The ideal solution to this problem would be using a stretchable conductive material that can be woven into washable and breathable fabrics, which remains a significant challenge. To address this challenge, I have formulated an innovative and interdisciplinary strategy based on my research experience to develop stretchable conductive fibres (SCF) using silver nanowires and spandex fibre. After developing SCFs, I will bring together diverse academic and industrial experts to utilize SCFs in 4 different research environments. First, I will receive intensive training at the Wireless Communication and Research Lab to utilize SCFs in wireless communication and pervasive computing systems. Then, I will integrate these systems into the disabled friendly apparels at Universal Textile Centre. Finally, I will be seconded to two industrial organisations, ComfTech and Antelope, to create SCF based prototypes of Health Monitoring Systems and Electro Muscle Stimulation technologies. This fellowship will allow me to gain new expertise in multiple disciplines, and build complementary international partnerships between academia and industry, which will enable me to enhance my independence as a researcher in the wearonics field. The successful completion of this timely and innovative pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Further genetic and epidemiological characterisation of hereditary breast cancer' (EUROBCLC) under Fourth Framework.

assistant: **Objectives**

Several genes have been identified which strongly predispose to breast cancer, giving rise to high-risk families. The two most salient ones are BRCA1 on 17q12-q21, and BRCA2 on 13q12-q13. The gene sequence of BRCA1 was recently elucidated and direct mutation screening is now feasible. BRCA2 has not yet been isolated, but its location on chromosome 13 is accurately defined by polymorphic DNA markers. The main objective of this proposal for a Concerted Action is to generate large well-defined data sets by means of specific data calls, which are powerful enough to address important questions in relation to gene mapping, genetic heterogeneity, the spectrum of cancer risks associated with different mutations, the effect of programmes of intervention for individuals at risk, and the use of genetic data from tumours for prognosis and management of patients. We expect to have assessed the genetic basis of the breast cancer predisposition in at least 350 families (250 BRCA1; 100 BRCA2). For BRCA1, this will allow the study of genotype-phenotype correlation's, and mutation-type specific cancer risks. For BRCA2, associated cancer risks and penetrance can be estimated. In the cohort of carrier women, the effect of known risk factors for breast cancer, such as parity and age at menarche, will be evaluated. In an attempt to identify genetic modifiers of the risk, polymorphism association studies will be performed in this cohort for a number of candidate genes. To investigate whether inherited breast cancer is a distinct entity relative to non-familial breast cancer, various somatic genetic changes, which occur frequently in sporadic breast tumours, will be characterised in at least 300 breast tumours from BRCA1- and BRCA2-linked families. In addition, their histopathology as well as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Three-photon fluorescence imaging deep inside scattering media' (DEEP3P), addressing dissemination and exploitation.

assistant: **Impact**

Investigating the complex structure and functioning of biological systems through light microscopy represents a foundational pillar of the life sciences. However, the very complexity of the samples cellular structure leads to one of the main limitations of optical microscopy: light scattering confines it to the outer most tissue layers. In the past decades, multiphoton microscopy successfully extended the accessible depth ranges and on a different front, advances in optical wavefront shaping showed that scattering can be compensated for, even in regimes where light fully lost its initial directionality. The aim of this action is to establish scattering correction through wavefront shaping in higher-order multiphoton microscopy, namely three-photon fluorescence imaging, to surpass the scattering barrier and reach unprecedented depths in optical microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'FRIAS COFUND Fellowship Programme for Junior and Senior Researchers - Phase 2' to be submitted under Horizon 2020.

assistant: **Abstract**

The Freiburg Institute for Advanced Studies (FRIAS) is an internationally renowned university-based institute for advanced studies that offers time-limited fellowship stays for excellent junior and senior researchers from around the world. The Institute is part of the University of Freiburg, one of the leading research universities in Europe. FRIAS is applying for a FRIAS COFUND Fellowship Programme (FCFP, phase 2) which will target experienced researchers at both the junior and senior level and offer them fellowship stays of up to one year to work on their own research project. Over the course of the FCFP (2017-24), 6 yearly calls for the academic years 2018/19 to 2023/24 will be issued, and a total of 804 fellowship months will be awarded, evenly split between Junior and Senior Fellowships. The proposed programme is an optimised continuation of the Institute’s current very successful COFUND project (FCFP, phase 1). If continued, the FCFP will form a central element of the Institute’s activities.The FCFP is open to researchers from all disciplines and nationalities. It features a transparent, merit-based selection process and offers internationally competitive employment conditions. Improvements of the FCFP (phase 2) with respect to phase 1 concern: the selection procedure, employment conditions, intersectoral networking and mobility, outreach activities, career development and alumni activities.The outstanding feature of FRIAS is its internationally diverse community of Junior and Senior Fellows from a wide spectrum of disciplines. Fellows pursue their project within the stimulating atmosphere of permanent academic exchange. Junior Fellows in particular profit from the dedicated support arrangements. The FCFP, phase 2, will continue to attract outstanding researchers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Research Infrastructures for Poverty Related Diseases' (EURIPRED).

assistant: **Concept**

HIV/AIDS, Tuberculosis (TB) and Malaria alone account for more than six million deaths worldwide every year. Despite substantial efforts made in recent years, Poverty Related Diseases are still spreading. New therapeutic interventions are therefore urgently required to combat Poverty Related Diseases. The existence of a well-developed HIV/TB/Malaria infrastructure presents a prime opportunity to address other sexually transmitted diseases such as viral hepatitis efficiently and effectively. The overall goal of the EURIPRED is to coordinate and integrate international resources into a single specialised infrastructure to support European HIV, TB, Malaria and Hepatitis B virus and Hepatitis C virus studies from early drug, vaccine and microbicide discovery to clinical trials. This will be achieved by creating partnerships between European scientists and international research teams from disease endemic countries and strong collaborations between industry and public sector research. Although vaccines, drugs and microbicide research is being conducted in the European Union (EU) there is no single European infrastructure that brings international resources and facilities together to develop cost-effective products for the European market. To underpin this need, EURIPRED will integrate worldwide resources to allow European access to shared reagents. This integrated approach will strengthen international cooperation, increase research capacity in EU and developing countries and significantly contribute to the European Research Area (ERA). By minimising fragmentation and duplication of research efforts and pooling fragmented resources EURIPRED can improve European research efficiency and effectiveness. EURIPRED will be built upon the highly successful model of the Centre for AI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced high temperature insulating fibres with safe physiological properties.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Inorganic fibres with diam. <3 µm; length >5 µm and L/D >3/1 can enter human lungs and cause cancer. Carcinogenic potential also depends on chemical characteristics; but most ceramic fibres and other fibres being used to substitute asbestos are also now on the WHO index. 'Bio-soluble' fibres have been developed which dissolve in the lungs; but due to poor chemical resistance this is not a solution to the problems of HT process industries. The project therefore aims at developing an inorganic HT fibre with geometry and material properties far from the WHO limits. Temperature resistance will be up to 1400°C. In addition the properties will allow textile manufacturing with flexibility similar to heavy textile fibres. The project will comprise material and process development for fibres, fibre processing into technical textiles and application research. SMEs active in material, fibre and textile manufacturing, big industrial end users and research institutes will be involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Comparative Connectomics: Revealing change and conservation in whole brain circuits across evolution' (CircuitEvolution) targeting Horizon Europe.

assistant: **Abstract**

Animals display remarkable diversity in their behaviors, yet very little is known about how nervous systems evolve to generate suchvariation. CircuitEvolution will answer two fundamental questions:1. How does brain wiring change across species as novel behavioral traits evolve?2. What core features of brain circuits are deeply conserved across species?We will use electron microscopy connectomics, the only method that enables unbiased, brain-wide structural analysis of the synapticconnectivity between all neurons. Building on recent rapid progress in Drosophila melanogaster, the frontier of whole brainconnectomics, we will target drosophilids at a strategically selected range of evolutionary divergences. Two PIs (Cardona, Jefferis) arepioneers in Drosophila connectomics, and our third PI (Ruta) and collaborators (Prieto-Godino, Benton) have pioneered moleculargenetic investigation of behavioral and circuit evolution across drosophilids. Crucially, with our fourth PI (statistical physicist, SalesPardo), we will identify conserved and divergent neurons and circuits across increasingly distant species, developing new inferencemethods for connectome alignment, simplification, and neuron annotation. Working together on this project we can develop a newfield of whole-brain comparative connectomics.With cutting edge technology, we will obtain and share multiple connectomes for 7 species. These unique datasets will allowcomparisons across species, sexes and developmental stages and support three areas of biological investigation within this grant:olfactory circuits, courtship behavior and the conserved core of the insect brain. This will generate many hypotheses that will betested experimentally by the PIs, collaborators and laboratories worldwide. The insights and methods will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Definition of a standard for footwear protecting against chemicals and micro organisms (CHEM-SAFE-FOOTWEAR)' to be submitted under Fifth Framework.

assistant: **Abstract**

The need for Footwear protecting against chemicals and micro-organisms in special industrial situations is well known and has been officially recognized in the directive ref. 89/686 EEC, annex II basic health and safety requirements, paragraph 3.10.2. This work has already been mandated to WG1 of CEN/TC161 'Foot and leg protectors'. At the present time, this lack is prejudicial for the notified bodies, which have important problem to assess the conformity to the directive of such products. The standard publication will clarify the market and would have an important industrial benefit for the footwear industry. The EN 374 test method for gloves will be used as a starting point for the development of test procedures. However it is recognized that footwear is more complex and uses different materials compared to those of gloves and therefore considerable method development will still be required. The final aim of this work is to propose a standard improving the CEN/TC 161 (WI 161.027) : Footwear protecting against chemicals and micro-organisms. (Document submitted for public enquiry November 1999)The major results of the project are:Definition of lists of:-the most important chemicals that need to be tested;-the most frequent materials used for the PPE market.Development of knowledge on the testing of footwear in a chemical environment.Proposition of a set of standard (including, test method, requirement, user information) to CEN TC 161 that would improve the current document of this Committee:-prEN 13832-1 Footwear protecting against chemicals and micro-organisms part 1: terminologie and test methods;-prEN 13832-2 Footwear protecting against chemicals and micro-organisms part 2: Footwear protecting against chemicals spraying - requirements;-prEN 13832-3 Footwear protectin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Adapting protein fate for muscle function and fitness' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Muscle function is essential for motion, exercise, and shivering, whereas physical inactivity is causally related to reduced metabolic fitness in animal models and humans. A critical requirement for muscle function is that proteins are properly produced and, if necessary, degraded to adapt the proteome to meet metabolic demands. However, there is a fundamental, open gap in understanding how challenges to muscle proteostasis are sensed and how protein fate is subsequently adapted to enhance muscle function in exercise or, conversely, how it is compromised in obesity. I hypothesize that protein fate is highly adaptive and can be fine-tuned to promote proteostasis, the integrity of muscle cells, and metabolic health. Identifying novel key regulators of these mechanisms in muscle may hold great therapeutic promise for targeting metabolic fitness to combat obesity and associated disorders. In this innovative project I want to define new mechanisms of muscle adaptation in humans and preclinical mouse models, with the ultimate goal of using this knowledge to improve muscle function and fitness in obesity. I will identify exercise- and obesity-specific substrates of the proteasome by ubiquitomics in human and mouse muscle and define how the ubiquitination and turnover of these proteins dictates muscle cell function. In a complementary approach, I will use novel loss- and gain-of-function mouse models allowing for precise muscle-specific manipulation of Nfe2l1, an adaptive regulator of proteasomal protein degradation, to define the biological and therapeutic significance of this pathway for muscle function in exercise and obesity. In summary, this novel work will provide a transformative molecular understanding of muscle adaption to metabolic challenges and provide insight into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electricity Storage and Demonstration of Renewable Energy Systems' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Specific Objectives:Battery Performance, Testing and Standards: Objectives: Verification of proposed drafts on test performance and test procedures for lead-acid batteries used in stand alone PV systems (solar home systems) as a pre-condition for their acceptance as international standards. Solar Home Systems: Methods and Standards: Objectives: Confirmation of the System Balance Point as a parameter to measure the energy rating of SHSs by comparing the indoor and outdoor test performance. Renewable Energy Systems Demonstration: Objectives: Construction of small demonstrator using RE and reverse-osmosis for drinking water production. This objective supports the development of arid areas in Member States and Candidate Countries. Analytical monitoring of PV-installations: Objectives: Continuation of our support role in the market penetration of PV systems by performing the analytical monitoring of DG TREN PV demonstration projects. Extension of this activity by proposing new/alternative means of monitoring. This objective also supports the penetration of PV in Member States and Candidate Countries. Anticipated milestones and schedule Milestones Schedule 1 1st Interim report on lifetime assessment of lead-acid batteries 30/06/2003 2 2nd Interim report on lifetime assessment of lead-acid batteries 15/12/2003 3 Draft proposal on test for battery assessment of SHS (own) 31/06/2003 4 Interim report on battery assessment for SHS 30/10/2003 5 Interim test report on SHS outdoor tests 30/11/2003 6 Design of water-desalination demonstration system 30/11/2003 7 Reports on PV demonstration projects Continuously. Planned Deliverables:1.1 Lifetime assessment of lead-acid batteries using already proposed tests procedures1.2 Test our own draft proposal for lifetime assessment of lead-acid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The first real-time monitoring and non-invasive medical device for personalised brain damage prevention during cardiac surgery' (BrainProtect), addressing dissemination and exploitation.

assistant: **Impact**

Over 2M Cardiopulmonary bypass (CPB) surgeries are carried out each year globally. Up to 83% of CPB surgeries result in neurological complications such as delirium and post-operative cognitive dysfunction (POCD) which significantly contribute to increased morbidity, disability, decreased quality of life and mortality rates up to 33% after 1 year. Only 45% of patients fully recover from neurological complications after 1 year post cardiac surgery, and in many cases severe brain damage is irreversible. Economic burden is huge amounting to €8.4B direct costs/year in the EU & US.Monitoring Cerebral blood flow autoregulation (CA) and maintaining adequate patient specific brain perfusion during CPB surgery is critical to prevent neurological injury. However, none of the current technologies is capable to identify cerebral blood flow autoregulation impairments before the neurons die within 4-5 minutes. This calls for the need for advanced solutions to protect patients’ brain and optimize neurological outcomes during CPB.ScienceForBrain has developed BrainProtect, a patented, novel periodic rectangular modulation of blood flow during CPB, making it possible for the first time to monitor CA transient functions almost in real- time and to identify start and finish moments of brain insults in individual patient with only 15-30 second delay. This enables targeted interventions to restore optimal personalised brain perfusion and protect the brain during CPB surgery. BrainProtect has the potential to reduce the risk of POCD and delirium by at least 50%, saving lives, improving QoL for patients and reducing €231M annually in direct healthcare costs.BrainProtect is currently at TRL6, we obtained excellent preliminary results in clinical trials with 173 patients, and we now need support