RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Performance of air-conditioning and refrigeration systems with non-ozone depleting refrigerants' (NODRI).

assistant: **Concept**

The proposed project is intended to appraise and then investigate the performance of new non-ozone depleting refrigerants and their required compatible lubricating oils. It will utilise computational skills and experimental equipment using expertise developed in a recent collaborative project. This will allow manufacturers to make use of new refrigerant materials that are being introduced to comply with environmental legislation. For the refrigerant side, testing will be performed initially on a single tube heat exchanger for various combinations of refrigerants lubricating oils and materials. Successful combinations will be used in simulated full scale heat exchangers and assessed in scaled laboratory tests. Computer modelling of practical heat exchanger performance will be undertaken for the combinations under test. Heat exchanger air side, air flow, and heat transfer performance will be modelled for typical practical applications and tested experimentally. The final project stage will be to verify research results and computer models by test verification in finished products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a yeast model to study aggregation of human tau and a-synuclein' (STAGGY) under Sixth Framework.

assistant: **Objectives**

The hyper-phosphorylated microtubule-associated protein tau is the main component of aggregated proteins forming, intracellular paired helical filaments and neurofibrillary tangles in brain-patients with Alzheimer and apos;s disease (AD). On the other hand a-synuclein is the major component of Lewy bodies, inclusions in brain, the main feature of Parkinson and apos;s disease (PD). Several reports suggest overlap in pathology, since both are found in plaques (AD) and Lewy bodies (PD), and since co-expression of alpha synuclein and tau triggers enhanced neuro-degeneration in transgenic mice.In order to understand molecular mechanism of aggregation we will develop humanized yeast models to study aggregation of tau, a-synuclein and the combination. We already demonstrated that yeast recapitulates several aspects related to the pathogenesis of tau and a-synuclein in neuronal cells as in double transgenic mice. The aim of this project is the further development and the use of yeast models to unravel the molecular bas is of tau and a-synuclein aggregation and their interactions.The project consists of several activities:(1) Study the effect of tau and a-synuclein phosphorylation on aggregation and toxicity in yeast (analysis of tau epitopes in combination with over-expression or deletion of appropriate kinases and phosphatases)(2) Establish a toxicity matrix in which the effects are described for co-expression of different phosphorylation variants and mutants of both proteins.(3) Evaluate the correlation between prot easomal/autophagic proteolysis and aggregation (in vivo observation of proteolytic processes and comparison with toxicity triggered by aggregation of both proteins)(4)Identify novel proteins involved in amyloidogenesis (screening of a human hippocampus cD NA and y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Family Politics, Party Politics, and Gender Politics: Comparing Five Cases' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Why are we seeing a proliferation of female politicians who members of political dynasties? Female politicians who are the wife, widow, daughter or sister of a prominent male politician have risen to the highest posts in politics as heads of parties and even heads of state. How can we account for this phenomenon? What does it mean about the trajectories of women in politics? Does the trend signal the rise of a new kind of power elite and a decline in democratic accountability? And finally, what does it tell us about transformations in early twenty-first century democratic politics? FAMGENPO proposes to compare the political trajectories of two successful cases of direct familial succession (Marine le Pen of France’s National Front, and Argentina’s President, Cristina Kirchner), two mid-range cases of successful indirect familial succession (Israel’s Tzipni Livni, and Chile’s Michelle Bachelat), and one failed case (Ségolène Royal of the French Socialist Party). Through interviews, participant observation, and analysis of archival material in Argentina, Chile, Israel and France, FAMGENPO aims to explain the rise of this phenomenon, including to unanticipated countries like France, just as many political parties have turned to elections in choosing party leadership. Existing scholarship on women in legislative politics cannot explain this trend. I propose to examine the relationship between social movements and political parties, past alliance practices of powerful, male leaders, the symbolic dimensions of being a political wife, widow, or daughter, and electorates and party rank-and-file seeking change by turning to women leaders at the same time as membership in a familial dynasty can offer a sense of stability. Finally, I plan to examine the possibility that electorate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multivariate selection and human-induced environmental stress: adaptive genetic and plastic responses in the yellow dung fly' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

One of the main tasks of evolutionary ecology is to characterize and explain the causes of phenotypic variation. Quantifying the relative contribution of genetic and ecological processes and their interaction is also important to predict future response of populations to human-induced environmental changes. The overall goal of the proposed research is to determine whether and to what extent two simultaneously induced new selection pressures are likely to slow or accelerate evolution relative to the case where only one selection pressure is present. In order to achieve this goal, I plan to collect extensive evidence on the nature of multivariate selection, genetic architecture, phenotypic plasticity, and evolutionary potential of Fennoscandian populations of the yellow dung fly (Scathophaga stercoraria). More specifically, the aims are 1.To compare the intensity and form of natural and sexual selection on fitness components across populations inhabiting six different locations in Fennoscandia 2.To relate the form and intensity of selection in the field with the genetic architecture of traits under selection using a laboratory quantitative genetic experiment 3.To examine changes in the potential for evolutionary responses to selection as a function of the number and intensity of stresses using a genotype by environment interaction experiment 4.To develop, parameterize and analyze a model of population and evolutionary dynamics under different predicted future environmental scenarios focusing on realistic description of ecological and genetic processes describing individual growth, survival and fitness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Optimised recycling of end-of-life vehicles'.

assistant: **Concept**

The targets set within the ELV Directive require that recycling of cars must be increased from the present 75% to 85% (by weight) as per January 2005. The car dismantling industry at present is not set up to deal with the electronics, plastics and windscreen waste that must be reclaimed, re-used or recycled under the forthcoming European Union End-of-Life Vehicle (ELV) Directive, and also under tightening landfill restrictions. The current 25% not being recycled is being dumped on landfill. This project is proposed to develop appropriate technologies to separate and track waste from different types of materials from end-of-life vehicles. An important requirement is to collect a pure and clean fraction of all separated materials as to obtain truly valuable reclaim.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Renewable Energy COordinated DeVElopment in the Western Balkan Region' (RECOVER).

assistant: **Concept**

The current non-sustainable patterns of the energy use in the Western Balkans stem to a large degree from the political, social, and financial instability of the region. To change these patterns, there is a need to address the full range of activities, nec essary to overcome the barriers to a large-scale penetration of RES. Key objectives To contribute to the sustainable energy development in the Western Balkan Countries, through: - Identification of the best options for RES utilization and technology transf er opportunities - Identification of research priorities and areas in the field of RES. Scope of work - Analysis of the current energy situation, energy strategy and policy, legal framework, distribution and use of RES, and the macroeconomic parameters in the Western Balkan Countries - Examination of the EU Member States' experience and achievements in the research field related to RES - Identification of the research and regulatory priorities concerning the realization of the best options for RES utilizat ion - Dissemination of the conclusions and recommendations among the policy makers, regulatory authorities, stakeholders, NGOs and investment community. Approach The available studies and information on the RES potential and technologies will be complement ed and utilised. On this basis, a comparative analysis of the different options will be performed and the option best for each country will be defined. In order to realise the coordinated development of RES utilisation, research priorities and regulatory measures will be identified and recommended.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring Cosmic Dawn with James Webb Space Telescope' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The cosmic dark ages - when the Universe was filled with neutral hydrogen that was opaque to ultraviolet light - are thought to have ended around one billion years after the Big Bang, when first light sources produced enough energetic photons to ionize the neutral hydrogen. This phase is referred to as the epoch of reionization and is also the era of the first galaxies' formation. However, this is also one of the least understood epochs in the Universe's evolution. When did it start/end?  Was it patchy or smooth? How did galaxies reionize the Universe (if they did)? What are the properties of the earliest galaxies? To answer these questions, this proposal will use deep observations of the largest sample of the most powerful cosmic telescopes that will be observed with the James Webb Space Telescope (JWST) right after its launch.  Compared to all previous facilities, JWST’s capabilities are dazzling. Its instruments will provide data beyond those yet seen by any astronomer. However, with high power comes great responsibility. Given its limited lifetime, excellent leadership needs to be established. As a key member of the Near-Infrared Imager and Slitless Spectrograph (NIRISS) team with guaranteed time and a member of the Early Release Science program, I am in a unique position to guarantee success of this project.  I am proposing to relocate to Europe. JWST's NIRISS instrument is not represented in Europe, and this program will bring immediate and proprietary access to the data. This proposal will (1) determine the timeline of reionization, (2) identify the exact role first galaxies played in this process by studying their ionized bubbles, and (3) determine stellar properties of the earliest galaxies. With an unprecedented facility, the program will undoubtedly bring man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Greenchem' under Fifth Framework.

assistant: **Concept**

The aim of this Summer School is to teach young post-graduate students the innovative scientific and technological background to approach pollution prevention for industrial processes from the chemical standpoint. The European chemical industry is addressing environmental problems in the effort to solve them and at the same time to improve the safety and the environmentally acceptability of its processes. Until recently the emphasis was placed on end-of-pipe remediation of environmental damage, rather than preventing it through smarter processes and more selective chemistry. The development of alternative clean syntheses for important industrial chemicals allows defining Green Chemistry as the use of chemistry for pollutant source reduction, and is aimed at sustainable chemical development and environmental protection. Its goal is to improve the quality of life and the competitiveness of industry.To this end, significant challenges are available for chemists to design new less polluting syntheses. Much of the training in this area initially came from within companies, but now graduates who possess these skills have a competitive advantage. Teaching will cover the following basic themes (Industrial Processes, Alternative Solvents, New Feedstocks and Products, New Reactions and New Synthetic Methods), and special topics selected according to the availability of the teachers. Three main focus areas can be indicated.1. The use of alternative synthetic strategies for green chemistry, such as: catalysis and biocatalysis, atom efficient processes, natural processes (photochemistry, biomimetic synthesis), alternative feedstocks.2. The use of alternative reaction conditions for green chemistry, such as: use of solvents that have a reduced impact on human health and the environme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gold(III)-based anticancer agents: dithiocarbamato-peptide derivatives as improved intracellular drug transfer and delivery systems supported by transporter proteins' (III), addressing dissemination and exploitation.

assistant: **Impact**

The ultimate objective of this research work is the preparation and evaluation of novel gold(III)-di/tripeptidedithiocarbamato complexes for combating cancer through their enhanced selective delivery at the tumor target site supported by transporter proteins. Platinum(II) drugs are now established as effective antitumour agents, the archetypal example of these being cisplatin. However, their usefulness is limited by their narrow spectrum of activity (not active enough against several types of cancer), and by both the development of acquired resistance after continuous treatment and toxicity (in particular, nephrotoxicity). Thus, several third-generation metal-based drugs have been prepared and tested. In this contest, gold(III) compounds are emerging as a new class of metal complexes with outstanding cytotoxic properties, and are presently being evaluated as potential antitumor agents. In particular, some gold(III)-dithiocarbamato derivatives were proved to be much more cytotoxic in vitro than cisplatin, and showed encouraging results in terms of both high in vivo effectiveness and lack of nephrotoxicity. This research project is concerned with the synthesis and characterization of new gold(III)-dithiocarbamato derivatives of di/tripeptides as improved peptide-based delivery systems, to be evaluated as antitumor drugs. The rationale behind our proposal is to design gold(III) complexes of the type [AuX2(pdtc)] (X = Cl, Br; pdtc = di/tripeptidedithiocarbamate) which can be able to both maintain the antitumor properties and the lack of nephrotoxicity of the previously reported gold(III) analogues, together with an enhanced bioavailability through the di/tripeptide-mediated cellular internalization promoted by transporter proteins. Thus, the enormous potential impact of thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tailored immune receptor engineering for resistance against rice blast disease' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Fungal pathogens are a major constraint to crop production worldwide. As part of their virulence strategy, pathogens secrete effectorproteins to manipulate host machinery and promote colonization. Effectors can be recognized by host immune receptors that launcha robust immune response that restricts pathogen spread. Pathogens quickly overcome immune receptor-mediated resistance bymodifying or losing effectors to evade detection. In the Tailored Immunity project, our aim is to massively expand the effectorrecognition specificity of immune receptors to provide durable disease resistance against the fungus Magnaportha oryzae, the causalagent of blast disease, and one of the most destructive diseases of rice. In order to do this, we will use a host-target guidedengineering approach to replace the heavy-metal associated (HMA) effector binding domain of nucleotide-binding and leucine-richrepeat domain (NLR) immune receptors from rice with the HMA domain of host proteins that are targeted by multiple M. oryzaeeffectors. We hypothesize that introducing the HMA domain of the newly identified effector hubs to NLRs will allow the simultaneousrecognition of numerous effectors. As the pathogen would need to undergo complex mutation pathways to escape this detection,and since changing multiple effectors is presumably associated with high fitness costs, we expect that this new strategy will generateresistance that the pathogen has difficulties to overcome and that is therefore highly durable. By these means, this ambitious project promises to provide a proof-of-concept for a new knowledge-guided and powerful approach for the creation of durable immune receptors that will be highly valuable for the improvement of a large range of crop species. In addition to boosting host immunity, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Pharmabiotec: drug design and transport'.

assistant: **Concept**

PharmaBiotec: Drug Design and Transport. The Marie Curie Training Site at the Royal Danish School of Pharmacy holds internationally recognized expertise in analytical chemistry, pharmaceutical chemistry, structural chemistry, medicinal chemistry, organic chemistry, natural products chemistry, pharmaceutical formulation, drug delivery, processing technology, clinical pharmacy, biochemistry, microbiology, pharmacology, molecular pharmacology, pharmacotherapy, and regulatory aspects. Applications are invited for post-graduate Marie Curie Fellowships at the Graduate School of Drug Research at the Royal Danish School of Pharmacy for periods of 3-12 months. Graduate students, of both genders, applying for longer stays will be preferred by the School. The successful applicants will participate in ongoing research projects related to the discovery, design, and development of drugs in a highly interdisciplinary and fruitful research environment in an interplay between the Graduate School of Drug Research and the European pharmaceutical industry. For more information on available research projects, please contact Dr.Jette Buur (jbb@dfh.dk), or check http://www.dfh.dk/activities/gradscool/index.htm. Applicants are expected to be pursuing studies for a pno-aeree in pharmacy, biochemistry, biology or chemistry in a field relevant to the drug design and development process. Fluency in English is required. Application, enclosing curriculum vitae and a letter of recommendation from the PhD supervisor, should be sent to Dr. Jette Buur, The Graduate School of Drug Research, The Royal Danish School of Pharmacy, 2 Universitetsparken, 2100 Copenhagen, Denmark.