RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Physiopathology of decompression : risk factors for the formation of intravascular bubbles during decompression'.

assistant: **Objectives**

Decompression sickness (DCS) is caused by circulating inert gas bubble formation in blood vessels and tissues resulting from supersaturation during inadequate decompression. It is an acknowledged risk of situations involving variations in ambient pressure, such as space flight and extravehicular activity, exposure to altitude, hyperbaric tunnelling intervention, as well as recreational and commercial underwater diving. Because new industrial challenges (human space flight programs, deeper planed tunnelling interventions and offshore oil excavation) and emerging recreational demands, the range of both environmental conditions and population characteristics involved in such activities regularly widen. Thus, new interdisciplinary approaches of decompression are needed to reduce risk for DCS.To foster knowledge of decompression phenomena, the PHYPODE ITN proposes to :- Develop an educational and research framework for cross-fertilization of currently fragmented research activities on physiopathology of decompression;- Give young researchers opportunities to share research techniques and resources, benefit from the best international scientists knowledge in this field, have the advantages of strong interactions between industry, medical centres and academia;- Widen career prospectives of young researchers by embracing the whole chain of research : from fundamental research for pathophysiological understanding of decompression to applied research in the industry for management of decompression.To achieve this training programme, academic partners, non profit association with worldwide activities, hyperbaric medical centres and industrial partners, with complementary expertises will build up the common agreed program concerning education and research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Galileo based navigation in public transport systems with passenger interaction' to be submitted under Seventh Framework.

assistant: **Abstract**

The idea of the proposal is, to develop a real public transport navigation system based on mobile devices, that give passengers the possibility to act as they are used to do it with common navigation systems in their cars. They will be able to get into  a vehicle and enter the destination into the system, jump off and on as often as they like to -  the system will always guide them to the destination. Passengers are not longer fixed on a printout of the route. They may change and interrupt their trips as  often as they like. To realise this, existing studies about Galileo, navigational systems, mobile applications from former projects and several sources will be analysed and flow together with user needs and general conditions into a meta study, the technical developments of the project will be based on. The focus of the project will be the development off all necessary applications for the navigational system based on a business plan, that is focused on a sustainable operation for all usual public transportation networks in Europe. Functional tests and demonstrations will verify the functionality and an evaluation and dissemination process will ensure the sustainable usability. Finally an effect analysis will evaluate and adjust the developed business models and ensure a successful knowledge transfer from research and development  to an operational service of the navigation system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The present and future impact of filamentous-fungal cell factories on the european health-and food-market' (1998-2002).

assistant: **Innovation**

The two main goals of the project are:1) to disseminate the results obtained in the EC projects EUROFUNG I and II (CT96-0535; QLK3-1999-00729) focussed on the improvement of health- and food-related fungal production processes;%l2) to determine the directions and priorities of fungal research for the coming 6-7 years. To reach these goals we plan the following activities:a) to organize a congress with all key players of the European scientific community in the field of fungal research on biotechnology and biomedicine together with representatives of the fungal industry, promising groups from NAS countries and biotech companies specialized in genomic technologies;b) to decide on the areas to be covered in a next European fungal research program with a limited number of key players and to assign tasks;) to finalize a blue-print for a new exciting framework VI program in a 2nd workshop and to initiate partner selection and proposal preparation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Magnesium Interactive Battery Community' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Energy storage is a key technology to facilitate a widespread integraWith the growing use of intermittent energy sources in power grids, there is a growing mismatch between when energy is produced and when it is consumed. This has led to the need of energy storage or demand-response systems in order to use the energy in a balanced and efficient way. Given this context, the Micro Energy Storage (MES) systems are expected to seek radically new approaches to supply energy where it is needed. Buildings are becoming a local use micro energy-hubs consuming, producing, storing, supplying energy and having the potential to take up an important role in the power-supply system stability which generate energy with renewables, provide storage for electric and thermal energy and deliver demand response. For Micro Energy Storage in Buildings (MESB) using stochastic renewables energy, the most suitable technology is the lithium-ion batteries (LIB). However, current LIB technologies are facing severe challenges in safety, energy density and price. While most of today's R&D is concentrated on LIB systems, shifting towards non-lithium rechargeable batteries may open up effective ways to overcome such challenges. The rechargeable magnesium battery (RMB) constitutes a paradigmatic example of such promising, alternative non-lithium energy storage systems, following pioneering efforts and breakthroughs from world-wide researchers. The potential to use metallic magnesium anodes in rechargeable batteries brings important advantages in terms of energy density, cost and safety. E-MAGIC gathers the key scientific and technical researchers in Europe to develop the required new frontier knowledge and foundational approaches on RMB, bringing an effective work on R&D by a rational design of high volt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Patient Centered Connected Health Model of Care for Huntingtons Disease' (CareHD) targeting Horizon 2020.

assistant: **Abstract**

HD is a monogentic disease, meaning modification in a single gene occurring in all cells of the body. In Western countries it is estimated that 5-7 people per 100,000 are affected by HD. Currently there is no cure for the disease and effective management is key to quality of life for those who are affected. Patients and families who are living with the disease face multiple social and self-management issues. For example, stigma of the disease alongside social isolation have been key drivers in terms of high levels of mental health difficulties. CH has the ability to assist with many of the difficulties faced by HD, RD and indeed other symptom related diseases. For example, CH can monitor and identify key intervention points along the disease progression pathway, it can inform and facilitate integrated care, it can assist with joining key stakeholders together in a shared ecosystem, and importantly it can assist patients and their families in terms of reducing isolation, optimising self-management and thus increasing empowerment and self-actualisation. Further, CH has the ability to optimise scarce resources in an over stretched health care system and thus produce effective and efficient outcomes.The primary aim of this RISE project is to establish an international and inter-sectoral network of organisations working in collaboration on a research project which seeks to design a technology enabled patient centred care pathway which will identify how to optimise Connected Health (CH) interventions at key points along Huntington’s Disease (HD) trajectory. This is an important project because patient centred care from a CH perspective in the area of HD is currently under developed. This project aims to develop a new pathway of patient care based upon a better understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The influence of climate change on coastal sediment erosin.' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The influence of temperature change on coastal sediment erosion The climatic changes predicted by the Intergovernmental Panel on Climate Change (IPCC) business as usual scenario"estimates a global rate of temperature increase of 0.25°C per annum over the coming decade. This temperature change is likely to have a major impact over all terrestrial and aquatic ecosystems. Of particular importance in terms of human interest are the changes that will be brought about at the interface region between land and sea. It is on the coastal zone that the main brunt of sea-level rise and increasing frequency and force of storm events will be expressed. Here ecosystems must change to keep pace with rising water levels and increase hydrodynamic forcing. The nature of this change and the way in which systems will respond is difficult to predict but is an important goal for environmental research. The CLIMEROD project encompasses an experimental and modelling approach to assess the likely effects of temperature change on elements of depositional system which control the physical stability and transport of coastal sediments. Physical features such as rheometrical properties effects on transport phenomena and biological changes such as enhanced productivity under increased CO2 will be investigated by an interdisciplinary team comprising hydrodynamics and biological modellers, microbiologists, sedimentologists, rheologists and mathematicians. The erosion of coastal sediment and the transport of suspended material is a critical factor in the prediction of change to coastal environmental systems. Many modelling studies have attempted to predict the behaviour of sediments yet there are no studies which address the likely scenario in the event of temperature rise with the inherent physical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cerebral Organoids: Using stem cell derived 3D cultures to understand human brain development and neurological disorders'.

assistant: **Concept**

Most of our knowledge on human development and physiology is derived from experiments done in animal models. While these experiments have led to a comprehensive understanding of the principles of neurogenesis, animal models often fall short of modelling many of the most common neurological disorders. Recent experiments have revealed characteristic striking differences in brain development between rodents and primates and may provide an explanation for this problem.The goal of this proposal is to use three dimensional organoid cultures derived from pluripotent human stem cells to reveal the human specific aspects of brain development and to analyse neurological disease mechanisms directly in human tissue. We have recently developed a 3D culture method allowing us to recapitulate human brain development during the first trimester of embryogenesis. Using this method, we will define the human specific brain patterning events in order to develop a culture system that can recapitulate essentially any part of the brain. Using a unique combination of cell type specific markers and mutagenic viruses, we will define the transcriptional networks defining specific neuronal subtypes. This will allow us to perform loss-of function genetics in human tissue to define transcription factors necessary for development of individual neuronal subtypes on a genome-wide level. Finally, we will apply the genome wide screening technology to human neurological disorders like microcephaly or schizophrenia to identify factors that can rescue disease phenotypes. This research proposal will provide fundamental insights into the cellular and molecular mechanisms specifying various neuronal subclasses in the human brain and establish technology that can be applied to a variety of cell types and brain r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Toward an HIV-1 vaccine:Molecular mechanisms regulating the cryptic innate immune response to HIV-1' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Our goal is to understand the innate immune response to HIV-1. We have found that a cryptic innate immune response to HIV-1 exists in dendritic cells (DC). This response is normally inactive because HIV-1 is unable to infect DC. We have used the Vpx protein found in other lentiviruses to render DC susceptible to HIV-1 infection. The resulting innate response to HIV-1 requires an interaction between de novo synthesized Capsid and cellular Cyclophilin A. This interaction leads to the IRF-3-dependant production of type-I interferon and the activation of antigen-specific T cells. This study will aim at understanding the molecular mechanisms controlling this response.In Aim 1, we will determine the host and viral factors implicated in the innate response to HIV-1. At the host level, we will evaluate a panel of candidate genes using a novel RNAi strategy using shRNA vectors in DC. At the viral level, we will determine the minimal viral elements required for triggering the response.In Aim 2, we will identify novel regulators of the innate immune response in human DC, including the DC-specific HIV-1 innate sensor. Using a DC cDNA library, we will screen for inducers of type-I interferon in cell lines. This library will also be used to identify the Vpx-sensitive HIV-restriction factor in human DC.The cryptic nature of the innate response to HIV-1 may explain in part the failure of the immune system to control HIV-1 in the vast majority of infected individuals, as well as the failure of current vaccine strategies. This study will provide a novel understanding of the molecular mechanisms responsible for innate immune responses, and may provide new immunological strategies for controlling HIV-1 infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TOR-mediated translational control of cytokinin homeostasis in shoot apical meriSTEM' to be submitted under Horizon Europe.

assistant: **Abstract**

Plant growth and organogenesis depend on the ability of meristems to integrate metabolic signals with developmental pathways. The shoot apical meristem (SAM) is a key developmental hub where nutrient availability and hormonal cues, particularly cytokinin, coordinate cell proliferation and organ initiation. The conserved kinase Target of Rapamycin (TOR) acts as a central regulator of these inputs, and its activity is essential for meristem activation and stem cell maintenance. Work from the host lab has shown that light and sugar activate TOR, which in turn promotes expression of the stem cell regulator WUSCHEL (WUS) and enables proper SAM function. Recent findings further reveal that TOR sustains shoot growth by repressing the translation of CKX transcripts, which encode cytokinin-degrading enzymes, thereby preserving cytokinin levels required for WUS expression and meristem activity. However, the mechanism behind this selective translational control remains unknown.TORcySTEM (TOR–cytokinin–merisSTEM axis) will dissect this regulatory pathway through three objectives:1) Identify TOR-sensitive cis-regulatory elements within CKX transcripts;2) Discover TOR-regulated trans-acting effector proteins;3) Establish how this control shapes cytokinin signaling and SAM function.Together, these aims will uncover how TOR-dependent translational control fine-tunes cytokinin homeostasis and stem cell activity, providing a mechanistic link between metabolism and shoot development.


**Keywords:** TOR signaling, translation regulation, meristem, cytokinin homeostasis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'When Satellite Navigation Meets Satellite Communication in Low-Earth-Orbit Satellite Systems' (INAC-LEO).

assistant: **Innovation**

In the realm of satellite systems, communication and navigation have traditionally functioned as separate systems, each requiring its own dedicated hardware. However, emerging wireless technologies present a game-changing opportunity: they can enhance navigation capabilities by the Low-Earth-Orbit (LEO) satellite systems and enable integrated systems that serve both communication and navigation requirements. This project aims to unlock the untapped potential of LEO satellite systems for Integrated Navigation and Communication (INAC), a critical step for Europe in developing cost-effective, dual-purpose satellite systems that could transform emergency services and Internet of Things (IoT) applications.The project is structured around three key objectives. Firstly, with the aid of LEO communication satellites planned by the European Union, Work Plan 1 (WP1) will establish a theoretical framework for LEO satellite navigation by using dynamic constellation characteristics and Doppler information. Secondly, WP2 will design a communication-aided navigation system that leverages the low-latency and high spectral efficiency of LEO communication satellites, aiming to enhance accuracy while minimizing computational demands. Lastly, WP3 will develop an integrated system that combines communication and navigation using next-generation multiple-access (NGMA) techniques, ensuring optimal performance in both communication and navigation without compromise. With a projected market impact potentially surpassing 10 billion Euros, this initiative stands to make a substantial contribution to the European space ecosystem, while providing groundbreaking solutions to global communication and navigation challenges.


**Keywords:** Satellite Navigation and Communications, Next Generation Multip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Construction of an integrated transcriptional map of the human X chromosome (3)' (1994-1998).

assistant: **Concept**

- - To construct a cosmid/PAC/BAC map of the human X chromosome with reference clones accessible to all participants and based on highly annotated YAC maps.- - To isolate and map the majority of X chromosome transcripts to the cosmide pockets and when established, to the cosmid contigs.- - To perform large scale sequencing of selected regions of the X chromosome, principally Xq28 and Xp22.With the availability of near complete coverage of the human X chromosome in YAC contigs, the participants aim at a coordinated effort to construct a map of bacterial vectors, as a substrate to the isolation of most of the transcripts of the chromosome. For both objectives, two different and complementary strategies will be used. First a global and systematic approach will be used by the coordinator. A minimal tiling path of YAC DNA will be isolated by long-range Alu-PCR and screened against a variety of reference cosmid, PAC and BAC libraries, thus constructing a pocket map of the chromosome. A cDNA library enriched for X chromosome transcripts will be constructed by laboratory in Heidelberg and made available to all participants. It will be systematically screened with cosmids from the pocket map to position transcripts. Secondly, a more regional approach will be used by key participants on the X chromosome, who have accumulated large amounts of material and expertise. The same cosmid libraries and selected cDNA library will be made available to all, and this will allow an efficient pooling of results. To this end a core database will be maintained by the coordinator and accessible by all participants through local copies of the same dataset. The complete network will be constructed with the IGD system, based on the ACEDB graphical database program. Large scale sequencing using state