RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Translating TCR–Antigen Pairing to Clinical Relevance: A Platform for Cancer and Autoimmune Applications'.

assistant: **Concept**

T cell receptors (TCRs) recognize antigens presented by HLA molecules and are central to immunity; nevertheless our ability to systematically map TCR-antigen pairs is still severely limited. Current approaches—individual antigen assays, multimer staining, or display systems—are either low throughput or biased towards known epitopes, and fail to deliver comprehensive datasets needed for therapeutic and diagnostic applications. This bottleneck hampers the discovery of clinically relevant TCRs and antigens for cancer immunotherapy and for autoimmune disease monitoring. In our ERC project, we developed a library versus library screening platform that can pair TCRs with their cognate antigens in an unbiased manner. Feasibility was demonstrated using model antigens, and the core technology is already the subject of a patent application filed by our institution. The goal of this Proof of Concept is to demonstrate the clinical utility of the platform by applying it to two major contexts: (i) TCR and tumor-associated antigen and neoantigen discovery in cancer, and (ii) TCR and autoantigen discovery in autoimmune diseases. By generating and validating datasets of clinically relevant TCR-antigen pairs, the project will establish the platform as a source of novel biomarkers and therapeutic leads. IP consolidation and a refined exploitation strategy will strengthen its translational potential. The expected outputs are: (1) validated datasets of TCR-antigen pairs with direct clinical relevance; (2) a reinforced intellectual property position; and (3) a detailed strategy guiding future commercial exploitation. This project will open a new avenue for precision medicine by enabling scalable mapping of TCR-antigen interactions in clinically relevant settings. It has the potential to acce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent cashflow management and forecasting platform  providing insights for financial decision making of SMEs' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cashflow is the lifeblood of any business and the accuracy of forecasting is critical to avoid shortfalls in cash balances, ensuring that payments can be made and ultimately avoid insolvency. Whilst there is an increased focus towards improving cashflow management, the inability to manage cashflow effectively is still a significant cause of small business failure: 50% of SMEs fail in the first 5-years, with 80% of failures due to cashflow issues. Cashflow management is a complex process, commonly delivered either by a remote book-keeper or an expensive in-house accountant. SMEs have a poor quality of these services and receive accounts days or weeks after a period end. Moreover these traditional methods often rely on projections based on a few historical data and inaccurate assumptions, posing SMEs at high failure risk. Fluidly is the first intelligent cashflow management software based on Artificial Intelligence and machine learning algorithms for accurate forecasting of cashflow in SMEs. Fluidly provides accounting firms and business owners with real-time insights about cash flow, its projection, associated risks and suggested actions. It enables accounting firms to provide additional service to SMEs - specific business recommendations according to big data and past actions. Fluidly saves time through automation and uses powerful data analytics with real-time notifications to draw attention to the risks, issues or actions that require further intervention of accounting firms and SMEs. Like an anti-virus software, Fluidly works away in the background providing peace of mind with proactive interventions when needed. During phase 1 of SME instrument, Fluidly will establish a sound go-to-market strategy and a supply chain, and draft further development plans. In phase 2,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coordination of European Research on Industrial Safety towards Smart and Sustainable Growth' in the context of a Seventh Framework call.

assistant: **Objectives**

Industrial safety is an enabling and important success-factor in the pursuit of beneficial business activities. For this reason, industrial safety is a vital and important prerequisite for sustainable growth and competitiveness of the EU. Therefore, there is an urgent need to refocus the resources of national research programmes in EU Member States on industrial safety since the problems related to industrial safety are common to all and cannot be tackled adequately at the national level. SAF€RA will bring dynamism into European research on industrial safety by fostering collaboration of national research programmes, by encouraging lateral thinking and by promoting innovations related to implementation of industrial safety. The Consortium consists of 19 leading public agencies, ministries and research organizations funding or managing safety research working in close collaboration with stakeholders from industry, enterprises, authorities, science, social partners and society at large. The strategic objective of the SAF€RA project is to create a research and innovation market through systematic exchange of information and a stepwise integration of national research programmes in the EU by creating effective instruments which will emphasize collaboration between national research programmes on industrial safety. The goal is thus to promote the incorporation of a more effective safety culture into EU industrial activities to improve the competitive edge of European industries on a global scale. The scope of the SAF€RA will be to support traditional industries to solve existing safety challenges and to promote innovative novel industries, such as bio- and nanotechnology-based industries, to consider safety issues in all their activities from the outset. The SAF€RA therefore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Delayed Transformational Fatigue in Central and Eastern Europe'.

assistant: **Innovation**

The aim of FATIGUE is to develop theoretically and empirically robust explanations for the causes and consequences of rise of illiberalism and authoritarianism in post-communist Europe (and Europe, more generally) with reference to the concept of 'delayed transformational fatigue'. The project will seek to answer the following questions:i. Why do illiberal political discourses resonate with people in post-communist Europe? ii. With which types of people do illiberal discourses particularly resonate? iii. Under which social, economic and political circumstances are illiberal discourses most likely to gain traction? iv. How do illiberal political actors make their views of the world hegemonic? Which social, political and economic conditions of possibility enable such hegemonic worldviews to dominate political discourse? v. Which framing activities are employed by cultural-political entrepreneurs via specific media and educational institutions to make their views of the world hegemonic? vi. What are the remedies to the current illiberalism? What role does education play in making society aware of the dangers of playing with right-wing ideas. The research programme will be organised in five work packages, each centred on a research theme pertinent to one or more post-communist EU member-states, accession states or states in the EU’s Eastern Partnership. A sub-team, composed of three partners, will lead the work on each of the five dimensions of the delayed transformational fatigue: WP1: Illiberal democracy and right-wing politics WP2: Politics of memory and transitional justice WP3: Economic populism and inequality WP4: Cultures of reaction: xenophobia, anti-Semitism, anti-migrant WP5: Civil society and protest movements


**Keywords:** illiberalism, authoritarianism, Centr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A new strategy for the diversity-oriented synthesis of skeletally diverse alkaloid-like compounds for chemical genetic studies'.

assistant: **Innovation**

Chemical Genetics research programmes require libraries of small molecules which span large tracts of biologically-relevant chemical space. Natural products necessarily reside in such chemical space, since they bind both biosynthetic enzymes and target macromolecules. However, natural product partners are not available for most protein targets.    Chemical Genetics has spawned diversity-oriented synthesis (DOS), in which libraries of diverse molecules are assembled in up to ca. five steps.  The systematic variation of ligand scaffold is particularly challenging, though, despite recent advances in DOS, the diversity of chemical libraries has not yet approached that of natural products because the ligand scaffolds are insufficiently varied. This proposal will focus on the development of new methodology for the synthesis of skeletally diverse alkaloid-like compounds.  A multicomponent reaction will be used to define an initial scaffold.  A suite of 'scaffold switching' transformations will be developed to allow the initial scaffolds to be transformed into final scaffolds.  The methods will be applied to the synthesis of at least 100 alkaloid-like compounds based on at least 10 distinct scaffolds.  The library of compounds will be made available, using robotics at Leeds, to European cell biologists for screening in cell- and protein-based assays.  The diversity and natural product-like nature means that it is likely to span large tracts of biologically relevant chemical space.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plug-in ADAptronic MODules for real-time errors (Thermal & Vibration) compensation and superfine positioning in reconfigurable high precision machine tools' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Ever increasing competition in international markets drives manufacturers to shorten design cycles and reduce manufacturing times and costs for their products. This trend generates a demand for smart, flexible and faster machining systems, which are easy to set up and configure and able to drastically increase productivity, while improving final accuracy. Therefore the primary goal is to achieve cost-effective structural solutions consisting of  a new class of “Modular Adaptronic devices” based on smart and multifunctional actuators/sensors  capable of performing a wide array of multiple functions, ranging from high and adaptable damping and stiffness characteristics to more demanding new requirements such as structural and measuring/ active-control function in order to achieve extremely high dynamic/thermal stability required in fast and precision machining. This project aims at designing, developing and validating the following novel adaptronic modules for machine tools applications: - Adaptronic interface for Active Vibration Control (AVC) and superfine positioning - Adaptronic framework for thermal compensation based on FBG fibre optics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Marine Bacterial genes and isolates as sources for novel Biotechnological products'.

assistant: **Innovation**

The overall objective of the research project is the development and application of a new molecular strategy to turn the hidden biodiversity of marine bacteria into novel biotechnological products. This strategy is based on an integrated molecular approach using bacterial DNA and RNA obtained directly from the marine environment to circumvent the need for cultivation since only a very small fraction, usually less than 1%, of the marine bacteria can be cultured. The molecular approaches used are gene cloning and expression of marine bacterial genes, estimation of the structure of bacterial communities that carry the genes in situ, and molecular characterization of bacterial isolates. This integrated approach will be applied to a set of diverse marine habitats to obtain information about i) the diversity of microbial genes in marine habitats and their carrying bacteria, and ii) the expression systems necessary to make the genetic information available for biotechnological products such as enzymes and antibiotics. The diversity of the microbial community will be determined with rapid molecular profiling techniques (5S rRNA analysis and denaturing gradient gel electrophoresis of 16S rDNA) that are able to give an quantitative overview about the abundant species in the community. A set of different cloning vector will be used to generate polygenomic clone libraries directly from the marine habitat. Expression of these genes will be attempted by different expression vectors followed by automated activity measurements in an industrial high-through-put unit. These activity determinations and molecular analysis in combination with microbiological and biotechnological studies will result in: i) commercial products, i. e. a variety of novel psychrophilic and mesophilic enzymes, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The missing link: how do membrane lipids interplay with ATG proteins to instruct plant autophagy' (LIP-ATG).

assistant: **Concept**

Autophagy is an intracellular catabolic process critical to eukaryotic life and indispensable for plant survival to drought, nutrient scarcity or pathogen attacks. Autophagy relies on the formation of specialized vesicles called autophagosomes (AP) which engulf and deliver cell components to the lytic vacuole. AP biogenesis is carried out by a group of dedicated proteins (named ATG) and hinges on intense remodelling events and on the remarkable capacity of an initial membrane, the phagophore, to assemble de novo, shape like a cup, expand while maintaining structure and function and re-shape to a complete vesicle. To date the molecular mechanisms underlying these events remain elusive. Research has focused on the role of autophagy proteins but, despite AP biogenesis being a membrane-based process, the fundamental contributions of lipids to AP membrane formation, identity and activities have been largely unexplored; in other words, when it comes to AP formation we are only looking at half of the picture.I propose to address the fundamental question of how APs form and shape from a novel angle: by exploring how lipids’ nature, dynamics and lateral heterogeneity instruct the phagophore structure, its protein composition and its functions. The project builds on our recent results and expands on strategies that we have developed, integrating proteomic/bioinformatic approaches, lipidomics and high-resolution 3D imaging. We will tackle 3 complementary objectives: 1) Reveal the dynamic lipid signature of the phagophore, 2) Elucidate the implication of lipids nature and repartition in the phagophore ultrastructure, 3) Decrypt the molecular mechanisms by which lipids interplay with ATG proteins to control autophagy activity and plant physiology. Overall the project will articulate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cross-Layer Design of Adaptive, Reliable and Energy Efficient Systems' to be submitted under Seventh Framework.

assistant: **Abstract**

Though current day designs carry the promise of meeting the ever escalating demands of high performance/ quality requirements, they often exhibit large power consumption that limits the battery lifetime and generates excessive heat. Besides power consumption, process variations also pose major design concern with scaling of devices that may lead to erroneous computations and loss of stored data threatening the correct operation of future systems.  Addressing both issues of low-power and reliable operation simultaneously is one of the most challenging design problems that semiconductor industry is facing today since they are contradictory in nature. The proposed project plans to address both issues by identifying and utilizing algorithmic level characteristics  that can allow the design of systems that provide the right trade-offs between output quality, energy consumption and parametric yield under technology imperfections. The feasibility of the proposed cross-layer design methodology is demonstrated by our observation that for DSP systems, all computations are not equally important in shaping the output response. For such systems, some computations are more critical for determining the output quality, while others play a less important role. This information is exploited in this proposal to develop suitable designs for logic and memory elements of wireless systems that are the core of all today’s portable devices. Main target of the proposed project is to reduce the high cost of existing variation-aware techniques and overcome the incompatibility of most of them with DSP systems. Furthermore, in order to improve the energy efficiency of systems the proposal will take into account system level interactions trying to limit the energy wasted in various blocks that may op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Wireless Optical/Radio TErabit Communications' under Horizon 2020.

assistant: **Concept**

5G promises increased connectivity, high data rates, and ultimately new services. The first 5G release standard in 3GPP will be available by June 2018 with pre-commercial deployment in Korea soon after. Whilst 5G will meet current demand, the exponential rise in demand for wireless connectivity will ultimately require Tbps connectivity in indoor spaces. The future network will use an all optical fibre core, and an ultra-high data rate wireless ‘bridge’ to the User.WORTECS focuses on the goal of ultra-high data rate wireless. High-frequency mm-wave (in the band above 90 GHz) radio communications will be combined with optical wireless communications in the infrared and visible regions of the optical spectrum, using novel heterogeneous networking concepts. A compelling virtual reality application will be used to showcase the capability of the WORTECS network. The project will deliver two Proof-of-Concept demonstrations. An ultra-high density LiFi/Radio network providing multi-Gbps to virtual reality terminals will be developed, and an ultra-high data rate Proof-of-Concept capable of Tbps networking will also be targeted.WORTECS brings together innovative, world leading LiFi SMEs Oledcomm (France) and PureLiFi (UK), Global telecommunications operator Orange (France) and research institutes BCOM (France) and IHP (Germany). These are joined by university research leaders in optical wireless communications from the University of Oxford (UK) and the University of Las Palmas (Spain). The consortium has the dual ambition of proposing new scientific solutions beyond 5G while transferring these technologies from research labs to industrial world. A successful project will both showcase technologies required to alleviate the radio spectrum crunch, and provide substantial benefits to