RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Feasibility of a secretome factory to treat paediatric interstitial lung disease' (NICHILD).

assistant: **Innovation**

Despite their astonishing clinical success on adults, there are still no mesenchymal stem cell (MSC)-based products approved for paediatric use. Preclinical studies support a potential beneficial role of MSC therapy to prevent progression in diseases called childhood interstitial lung disease (ChILD). However, MSCs still suffer from the cost of culturing and storage facilities and a lack of standardization of cell populations, their quality and quantity, donor-related factors, protocols for isolation, in vitro expansion cell delivery and dosing. Our goal is to standardize and automatize the production of MSC secretome and validate it for its translation to paediatric use to treat ChILD. We will explore the feasibility of a “secretome factory” based on (1) isolation of MSCs from donor bone marrow, (2) expansion of MSCs in a micro scaffold called nichoid and (3) long-term culture of MSC for secretome production in an optically monitored bioreactor called MOAB-nichoid.To achieve these goals, in this PoC we will validate the main key performance indicators of the production process and prepare a go-to-market strategy for the secretome biodrug. Our outcomes will be 1) a MOAB-nichoid production line, with total costs compatible with its industrial production and marketing by a pharmaceutical company; 2) standard operating procedures (SOP) for the production process in full compliance with the GMPs in the sector of cell and tissue therapy products (PTC); 3) secretome quality parameters obtained through a comprehensive characterization; and 4) demonstration in vitro of the safety and therapeutic efficacy in the pathologies studied. The outcome of this project will provide a national and international reference point for the industrial production of MSC secretome to treat ChILD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SEESWIND, Silent, Efficient and Economic Small Wind Energy.' (SEESWIND), addressing dissemination and exploitation.

assistant: **Impact**

In the current context of more than 50% dependency on energy imports, increasing fuel and electricity prices and climate change threats, Europe is in a great need to foster its internal production of renewable energy.Small wind can play an important role in meeting this challenge by providing reliable decentralized renewable energy. However, there are a number of technical and economic barriers the small wind industry needs to overcome in order to become fully competitive. These include low performances in urban environments with slow and turbulent winds, high noise levels, need for reliable safety systems to avoid over-speeding, risks to birds and high upfront investments for the purchase and installation of the technology. Existing market solutions only cover a certain range of wind speeds and have low performances in slow winds. They also cause uncomfortable noise with levels that can reach 60dBA - above WHO standards (40 – 55 dBA) - while posing a collision hazard for birds during flight. In economic terms, the average final installed costs of a small wind turbine are around €10,000 to €15,000. SEESWIND is the first technology in the small wind market that offers solutions to cover the full range of winds and user demands thanks to its modular and easy to install (plug & play) configuration, ensuring a silent (0 dBA), efficient and safe performance while reducing by 10-40% the overall final cost for the user. SEESWIND’s feasibility study will aim at exploring our commercial strategy, including the definition of modules with highest commercial interest,  technical feasibility and markets analyses, as well as a ‘freedom to operate’ study, in order to define our SEESWIND business plan. SEESWIND will be out in the market by 2018 at a selling price of € 6,300. We expect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A satellite telecommunication and internet-based seismic monitoring system for volcanic eruption forecasting and risk management'.

assistant: **Objectives**

1. e-Ruption will create a prototype network forecasting and early warning system for improved prediction of volcanic eruptions, based on an analysis and classification of diagnostic seismic signals that are precursors to volcanicactivity;2. e-Ruption will provide risk information on potential volcanic eruptions to environmental and civil protection agencies at volcanically active sites;3. e-Ruption will allow volcanologists, environmental and civil protection personnel, and the general public to access a database server system in real time via the Internet and high-bandwidth terrestrial and satellite communication networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum Properties of Distributed Systems' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

QUPRODIS is a Thematic Network/Working Group on the quantum information processing and communication capabilities of distributed quantum systems. The Working Group will classify and quantify the quantum resources, like multi-party correlation and entanglement, how they propagate in distributed quantum systems, and how they are affected by local operations, classical communication and physical interactions. We shall consider a variety of architectures, ranging from quantum networks, where the processing units can be individually addressed, to quantum lattices, where this is not necessarily the case. We shall also explore novel computing methods, like the measurement- and noise based computing, and non-standard architectures, like the quantum cellular automata model and the quantum neural nets.OBJECTIVESThe QUPRODIS Working Group will support, enhance, and complement the research on quantum information processing and communication in distributed quantum systems by promoting and facilitating appropriate links between the QUPRODIS partners, between the QUPROIDS partner and other projects of the QIPC cluster, and the QUPRODIS partner and researcher/research-groups working in other fields. The QUPRODIS will assist in the coordination of the QIPC cluster and it will provide input to the QIPC Roadmap.DESCRIPTION OF WORKThe project comprises theoretical investigations on the quantum information processing in distributed quantum systems. Research will be conducted by three interrelated Focus Groups FG1 'Characterization', FG2 'Manipulation', and FG3 'Implementation'. Each Focus Group is assigned a number of research packages which describe the Focus Group specific tasks in some detail. Focus Group FG1 deals with the mathematical characterization of entanglement and correlation in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced Visual Optics' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The recent observation that central refractive development might be controlled by the peripheral retinal image quality revived the interest in the peripheral optics of the eye. In general, this means that the temporal evolution of the ocular optics at the early stage of life will not be fully understood unless a full description of the optical components (cornea and crystalline) is given together with the angular positioning and the peripheral optical quality assessment. This would constitute the most complete picture of the development of the optics of the eye, being essential to understand the etiology of several ocular diseases like myopia or strabismus. The measurement in infants and children represents a technological challenge. A corneal topographer should be redesigned to work on distance, and be as less disturbing as possible. The ocular alignment (angular distance between the line of sight and the best optical axes of the eye) might be assessed with the same instrument. We propose here the development of a Hartmann-Shack wavefront sensor to measure not only on-axis aberrations but also the peripheral image quality. All the instrumentation will be used in a cross-sectional study of the ocular optics at the early stages of life, from newborns to adulthood. A second line of related research will focus on the possibility of reducing the progression rate of myopia during ocular development. Recent experiments support the idea that a peripheral hyperopic defocus might promote central myopia. To induce the opposite effect, a set of lenses to selectively impose myopic peripheral defocus on certain areas of the retina will be designed and will be tried in a group of children with incipient myopia. In conclusion, this project expects to provide for the first time a compl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cultivated Adult Stem Cells as Alternative for Damaged tissue' (CASCADE), addressing dissemination and exploitation.

assistant: **Impact**

Rapid progress in stem cell research pave the way for the development and use of new cell therapy products in regenerative medicine. The objective of CASCADE is to provide the European Community with unique expertise which focuses on the GMP production of mesenchymal stem cells (MSC) and their use in treating skin and corneal wounds, so that quality and safety criteria are paramount and match therapeutic expectations. Commencing with known procedures, CASCADE will develop innovative technologies based on the expertise of its partners. Among our research themes, the specific issue of multiple recipients and universal donors will be investigated. To this end, human MSC will be derived from 4 tissues, bone marrow, fat tissue, cord blood and amniotic membrane, according to good manufacturing practice (GMP). Phenotypic identity of GMP produced MSC, their genetic status and their potential for transformation will constitute the basis for establishing standards for controlling cell production. The efficacy of GMP produced MSC will be tested in in vitro and in vivo models, and the immunological consequences of their use will be studied. Moreover, during the whole CASCADE initiative, ethical and legal issues raised as a result of MSC therapies will be considered. Direct collaboration with two clinical networks will allow CASCADE to finely tune production specifications, and define optimal clinical protocols for these MSC-based cellular therapies. CASCADE will therefore gather together leading European cell therapy laboratories with unrivalled expertise in the production of therapeutic cells and in MSC biology, four SMEs with specific know-how in GMP production of cells and two clinical networks in dermatology and ophthalmology. The outcome will be a consortium that encompasses a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automotive Chassis Development for 5-Days Cars' (AC-DC) targeting Sixth Framework.

assistant: **Abstract**

The prime objective of AC-DC" is to develop a concept, which radically enhances automotive manufacturing in order to achieve the high level of responsiveness required for a 5-Days car according to customer specifications and to validate/demonstrate the novel approach using the characteristic component light-weight chassis as a master. This calls for both a determined step forward in motor vehicle technology combined with a dynamic planning process involving the full supply chain. In order to break with the traditional hierarchic manufacturing revolutionary concurrent elements must be introduced that reduce stocks and allow last moment configuration of new products in higher variations and quality and at lower costs."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovation Capacity Building by Strengthening Expertise and Research in the Design, Planning and Operations of Green Agrifood Supply Chains' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

GREEN-AgriChains aims at improving the research capacity of the Aristotle University of Thessaloniki (A.U.Th.), Greece in order to establish the University as a prominent stakeholder of innovation in the areas of Green Supply Chain Management (SCM) and Logistics, focused on the Agrifood sector. All aspects of supply chain design and planning that support green image will be tackled, including sustainable farming, reverse logistics, green procurement and sourcing, waste management and packaging reuse, transportation, energy consumption efficiency, green marketing, green accounting, and corporate social responsibility.To that effect, strategic partnerships with seven well-established research institutions will be developed and additional twinning with four industry stakeholders and policy-makers will be facilitated, while the focused recruitment of eleven experienced researchers will add the missing pieces to the existing portfolio of researchers of the project partners. Furthermore, synergies between leading SCM and Logistics practices and the Agrifood sector are expected to act catalytically in unleashing innovation and opportunities for added-value products and services in the sector.Dissemination activities such as organization of five workshops/seminars, and one  conference will contribute to the spreading of best practices and the exploitation of the project results and knowledge in particular throughout the Agrifood Industry. All stated activities will sustain the progress of real integration and cohesion of the Greek Agrifood sector into the EU Framework logistics-oriented Programmes and promote Green Development for the regional economy. Finally, an ex-post evaluation of the research potential of the applicant will provide valuable feedback to the research team a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Systematic analysis and modeling of the gene regulatory network underlying neural tube patterning'.

assistant: **Objectives**

In many developing tissues, initially equipotent cells acquire their intended identity by exposure to extrinsic, graded signals termed morphogens, such as Sonic Hedgehog (Shh). In the ventral neural tube, Shh induces 5 progenitor domains in a precise spatial order along the dorsoventral axis of the developing spinal cord. These domains can be distinguished by the expression of different combinations of transcription factors (TFs). During their specification, the progenitors transit through several metastable states, exhibited by the expression of different combinations of TFs. In network analysis terminology these states define so-called attractors – states of equilibrium towards which global gene expression profile tends to move. We predict that ventral neural tube progenitor states correspond to such attractor states that are generated by a gene regulatory network (GRN) controlled by graded Shh signalling. We will use a series of experimental and in silico approaches to systematically decipher and model this GRN. We will perturb the GRN in the developing chick neural tube using in ovo electroporation of constructs that change the level of Shh signalling and/or the expression of specific TFs. The consequences on the transcriptome of neural cells will be assayed systematically. Factors newly identified in this analysis will be examined and their function in the transcriptional response of neural cells assessed. We will use this approach iteratively to build, challenge and refine our model, and progressively understand the principles of the network. This will define the attractor states of the system and identify the TFs that contribute to the establishment of these states. By extending our knowledge of basic mechanisms of neural tube development we hope to provide new i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pre-commercialization of circadian clock-drug interactions screening tool for therapeutic applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Circadian clocks carry an immense importance to human health, as clock disruption is related to various malignancies from sleep disorders through diabetes to cancer. Furthermore, many drug targets are influenced by circadian clocks. In order to maximize drugs efficacy while minimizing side effects, it is necessary to consider the drugs time-of-administration, also known as chronotherapy. These revelations are critical for drug administration and development. However, their practical implementation is tempered by the lack of suitable research tools that bridge the gap from the bench to the clinic. The time-dependent effect of an intervention on the clock is represented by the Phase Transition Curve (PTC). PTCs retrieval is laborious and challenging, consequently they were mostly overlooked in the pharmaceutical R&D process. In the ERC Project CIRCOMMUNICATION, we studied clock-resetting mechanisms, which led to the development of CircaSCOPE, an efficient high-throughput methodology for high-resolution PTC construction. CircaSCOPE can be used as a powerful screening method for clock-modulating drugs, either for the purpose of targeting pathologies associated with circadian disruption, or to identify drugs which elicit unwanted side-effects on the clock. Once fully developed and systematically integrated in chrono-medicine, CircaSCOPE has the potential to improve drug discovery and yield medicines with better therapeutic index.Here, we detail our plan for the first steps toward commercializing of our innovation. We will demonstrate the applicability of this approach through drug libraries screens and expand the repertoire of cell types that the system relies on. In addition, we will explore different commercialization strategies and interact with potential stakeholders and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'TWINNING TOWARDS SCIENTIFIC AND TECHNOLOGICAL EXCELLENCE IN PLANT PROTEIN RESEARCH'.

assistant: **Innovation**

Three key global drivers underpin the increased interest in plant protein-based diets: population-growth, important role of proteins in a healthy diet, and the environmental impact of animal-based food chains. While an increasing trend in proportion of plant sources included in diet is obvious, the current generation of commercial plant-based alternatives is suboptimal. More research is needed to obtain a comprehensive understanding on the impact of plant proteins on technological and nutritional functionality, including their digestibility and effect on gut microbiota. Despite high potential of protein crops in Türkiye and TÜBİTAK’s national reputation in plant-protein research, this is not sufficient for its scientific recognition among the EU's leading Institutes. Therefore, TÜBİTAK must improve its scientific and technological capacity, build a strong international network, and fill the gaps of this emerging protein for food field. In this context, PROTWIN is the most appropriate tool for TÜBİTAK to build a capacity development system at national and EU levels and being able to timely capture opportunities in the field of plant proteins research. The overall objective of PROTWIN is to stimulate scientific excellence, widening and strengthening networking activities between TÜBİTAK and top-class leading counterparts in EU in “plant protein innovation for food domain” by linking it with Aarhus University, University of Liege and CNR-ISPAAM. The significant complementarities between these institutions, processing, digestion, and gut microbiota for health, and -omics analytical platforms will enable through networking excellence in research and innovation, through knowledge transfer and exchange of best practice. PROTWIN will help raise the research profile of TÜBİTAK a