RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Genetic variation in the susceptibility of Drosophila to infection'.

assistant: **Concept**

Insects vary in their susceptibility to viral infection, and this variation affects disease transmission by vectors and the survival of beneficial insects.  Identifying the genes that cause this variation will provide insights into both the molecular interactions between insects and their parasites, and the processes that maintain this variation in populations. We propose to do this in Drosophila, where genome-wide association studies are now possible thanks to the publication of large numbers of genome sequences. Furthermore, new techniques allow the sequence of Drosophila genes to be precisely altered, which will allow the exact molecular changes affecting resistance to be confirmed experimentally. Using these powerful techniques, we will first identify genes that affect resistance to a diverse panel of different viruses, which will allow us to understand the molecular and cellular basis of how resistance to different groups of viruses evolves in nature. Next, we will repeat this analysis using different isolates of the same virus, to identify the molecular basis of the ‘specific’ resistance commonly observed in invertebrates, where different host genotypes are resistant to different parasite genotypes. Once we have identified the polymorphisms that affect resistance, we can then use these results to examine the evolutionary processes that maintain this variation in populations: are alleles that increase resistance costly, how has natural selection acted on the polymorphisms, and is there more variation if the virus has naturally coevolved with Drosophila than if the virus was isolated from another insect. Finally, by hybridising D. melanogaster to D. simulans, we will extend these experiments to identify genes that cause species to differ in resistance, which will re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Probing the Memory of Earth Anoxia: New Stable Isotope Constraints on the Rise of Oxygen' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Atmospheric anoxia prevailed throughout the majority of Earth history, making oxygen and the animal life it supports relative newcomers to our planet. O2 accumulated in Earth’s atmosphere during two dramatic oxygenation events at ~2400 and ~600 million years ago (Ma). Both of these events were accompanied by profound biological and geochemical revolution, including the origin of animal life, making them amongst the most important events the Earth system has ever witnessed. Because the composition of Earth’s ancient atmosphere cannot be measured directly, its history must be examined using models constrained by geochemical proxies. The disappearance of sulfur isotope mass-independent fractionation (S-MIF) from the sedimentary record ca. 2320 Ma is considered the “smoking gun” evidence for the permanent oxygenation of Earth’s atmosphere. However, it was recently suggested that weathering of older S-MIF bearing sediments resulted in a prolonged S-MIF “memory effect” that lasted ~200 Ma or more, thus obscuring the true history of atmospheric oxygenation. Here I propose new hypotheses to test, for the first time, the importance of the S-MIF memory effect at the onset of atmospheric oxygenation. I will evaluate specific sulfur, strontium, and oxygen isotope signals from exciting new samples obtained through a recent French drilling program to help resolve this fundamental problem in Earth system evolution. As an American Experienced Researcher, this Marie Curie project, ANOXIA-MEM, is designed to harmonize my unique isotope geochemistry skills with the knowledge, resources, and training capacity of two renowned French isotope laboratories for the maximum benefit of all parties. This project promises new tools and analyses that are uniquely poised to upset the prevailing parad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Interconnecting innovation ecosystems for common European data space in Health' under Horizon Europe.

assistant: **Concept**

The aim of the project is to foster the dialogue and development towards more inclusive, dynamic, (gender) diverse and interconnected innovation ecosystems in Europe to reach the European common data space in health. The joint action plan to be developed in the context of the project is oriented at overcoming the current deployment gap of digital health in Europe and to unlock the power of health data for innovative medicine and healthcare of the future, enabling new scientific discoveries, innovative commercial health products and services, all in all resulting in more efficient prevention and treatment of illnesses and ensuring a better quality of life in Europe and globally.The consortium includes four clusters/networks, all representing broad innovation ecosystems, that have for many years been working to advance the secondary use of health data and creation of the common European Health Data Space. This includes Biocat, BioRegion of Catalonia (Biocat; coordinating country: Spain), Council of European BioRegions (CEBR; based in Belgium), Health Cluster Portugal (HCP, Portugal) and ScanBalt network (SB; Estonia). The consortium takes leadership in coordinating the project activities but a wide range of clusters, bioregions and wider ecosystem stakeholders will be engaged in the project based on the joint effort of the core partners.


**Keywords:** European Health Data Space, digitalisation, interconnecting ecosystems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-scale BiOmechanical characterization of peri-iMplant Bone tissue: influence of the environment' (BOMB) targeting Horizon 2020.

assistant: **Abstract**

Orthopaedic and dental implants are commonly used clinically. Their success rely on adequate primary and secondary stabilities, the latter being achieved through osseointegration, where bone grows around and onto the surface of the implant. However, prosthesis anchorage failures are still experienced and remain difficult to anticipate. The biomechanical properties of the bone-implant interface are the essentials for determining the implant stability but are still poorly understood. The objective of BOMB is to better understand the multiscale evolution of the biomechanical properties of the bone-implant interface with the overall aim to improve the long-term stability of implants. The project will use and further develop a standardized implant model of the host team to limit the influence of the implant geometry on osseointegration. Animal experimentation on rabbit and sheep will enable to work in a controlled as well as enhanced environments, using bone marrow stem cells, which are thought to be a promising new therapeutic tool to boost implant integration and hence improve implant stability. BOMB will combine the latest and advanced multimodal techniques spanning the nano and micro-scale to explore the structural and mechanical properties of the interface on a same sample. For instance, neutron high-resolution micro-tomography, a technique adapted to the presence of metallic components, has barely been applied on bone and will enable investigation of the microstructural properties of the interface. A successful completion of BOMB would represent a major step forward our limited understanding of the bone-implant biomechanical behaviour. This will lead to the development of new models, regenerative strategies as well as new implants to improve dental and orthopaedics sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A neural networks based model for automatic performance of musical scores' (1994-1998).

assistant: **Concept**

The aim of the project is the development of a general concept for local search operators. The identification of optimal operators for solving a given combinatorial optimisation problem is fundamental for an efficient local search approach. This is true for both, point-based local search methods (local hillclimbing, simulated annealing) as well as for population-based local search methods (genetic algorithms). in the first place, the concept deals with unary operators as used in point-based local search methods. However, since recombination operators as usually found in genetic algorithms, can be traced back to unary operators the concept also applies to genetic algorithms and thus provides a general framework. In particular, such a concept is expected to improve the current design methodology for local search algorithms. Furthermore, it may give rise to an alternative theoretical explanation for genetic algorithms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'THE DEVELOPMENT OF NOVEL PHOTOSWITCHABLE KINASE INHIBITORS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overall research objective of this project is to develop novel photoswitchable kinase inhibitors (PKIs), targeting on REarrange during Transfection (RET) for use in living cells and in zebrafish (Danio rerio). Controlling the action of kinases in a reversible way will have an exceptional potential for investigating signal transduction in zebrafish. In this work, photoswitchable RET kinase inhibitors based on azo-functionalized pyrazolopyrimidines will be developed, enabling photonic control of RET activity with substantial differences in inhibitory activity between the two photoisomeric forms. Such RET inhibitors are currently not available. RET is expressed by the immune cells of the brain, the microglia and is mediating activation of the cells. Microglia has been shown to be responsible for both protecting and harmful effects in neurodegenerative disorders. Although RET has been shown to be involved in neurodegeneration, its role in Alzheimer’s disease (AD), where microglia play an important role, is not known. The ability to manipulate the activity of RET using light would result in temporal control of enzymatic activity, thus serving as a valuable molecular tool to study the function of RET in microglia cells and further our understanding of AD.The research project is (1) highly interdisciplinary, (2) timely due to the recent interest of photopharmacology and (3) innovative by combining zebrafish imaging with photopharmacology to study signalling relevant for development of AD. This fellowship will ensure the best possible career opportunities for me as I will receive substantial training in cutting-edge approaches, gain mentor and supervision skills, presentation skills and critical assessment skills, largely expand my collaborative network, and gain the fundam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analog Photonic Computation' in the context of a Horizon Europe call.

assistant: **Objectives**

For over 5 decades, digital electronics has covered the increasing demand for computing power thanks to a periodic doubling of transistor density in integrated circuits. Currently, such scaling law is reaching its fundamental limit, leading to the emergence of a large gamut of applications that cannot be supported by digital electronics, specifically, those that involve real-time analog multi-data processing, e.g., medical diagnostic imaging, drug design and robotic control, among others. Here, an analog computing approach implemented in a reconfigurable non-electronic technology such as programmable integrated photonics (PIP) can be more efficient than digital electronics to perform these emerging applications. However, actual computing models were not conceived to extract the benefits of PIP.The aim of ANBIT is to develop an entirely new class of computation theory – termed Analog Photonic Computation (APC) – specifically designed to unleash the full potential of PIP technology. The core concept revolves around the idea of performing analog operations on a new unit of information, the analog bit or anbit, conceived as a two-dimensional analog function and matched to the building block of PIP circuits.ANBIT will reach its objectives by: 1) developing the theory of APC based on operations (gates) of anbits, 2) translating the principles of APC to the design of PIP circuits by concatenating single- and multi-anbit gates, 3) fabricating, packaging, testing and validating silicon PIP chips capable of implementing complex APC architectures, 4) designing, coordinating, setting and performing experiments that will prove the unique potential of APC in computational and signal processing applications with huge takeover.ANBIT will deliver a new computing paradigm that extracts t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Production back to Europe – through a novel/green manufacturing process of TERbinafine API synthESis' under Horizon 2020.

assistant: **Concept**

Synthetics Int. AG is a Swiss company strongly R&D driven which holds a variety of IP/commercial processes in the chemical business focused on the custom manufacturing and multi-customer products for the fine chemical market and the supply of polyfunctional cross linkers, tailor made manufacturing equipment, and natural products for treatment of wood. With a consolidated 20 years of history, Synthetics is a reference in the fine chemistry market. Within this project, in order to improve the synthesis of one of the most efficient dermatologic antifungals in the market, Terbinafine Hydrochloride, Synthetics has developed TERES, an innovative manufacturing process for this API, achieving a cycle time reduction from 6 steps to 2 steps by using a clever catalyst in order to accelerate the reaction. This implies a lower operation time and, at the same time, raw materials savings and environmental costs reduction (water/air, energy, solvents and toxic products). In addition, a better impurity profile is achieved, what means less risk of side effects in the drug product and purifying costs reduction. Consequently, Synthetics can ease the move Terbinafine manufacturing back from India (currently 80% of production) to a manufacturing plant in Denmark with an extreme competitive pricing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting RNA as an approach for treating retinal disease' (RETORNA).

assistant: **Concept**

Today, vision impairment up to total blindness represents an increasing global problem with significant social and economic impact upon affected patients and society as a whole. Despite the advancing of knowledge on their genetic basis, there is no effective cure for retinal diseases (RD) to date and therefore there is an urgent need to fill this gap.The present DN “Targeting RNA as an approach for treating retinal disease” (RETORNA) aims to treat RD by using RNA therapy. Among the research objectives, we will study different types of RNA that are expressed in retinal cells. By observing bioinformatic models, cell and tissue cultures, animal models, and human patients, we will be able to create RNA profiles for different RD. This screening will identify several targets that will be used as therapeutic approaches. Then, selected RNAs will be used to treat different RD, such as macular degeneration and retinitis pigmentosa. Furthermore, the potential economic and social impact of such strategies upon European countries will be studied, and the possibility of commercialization will be assessed.RETORNA proposes breakthrough research, distributed in 10 individual projects, performed by 10 Doctoral Candidates (DCs). Some of the most highly qualified European scientists of the field will supervise those DCs, who will be awarded with a PhD at the end of the program. Moreover, DCs will be provided with different transferable skills, necessary for starting successful careers in academia, but also in other areas: industry, public organizations, non-profit organizations, consultancy, etc.The RETORNA consortium consists of 8 beneficiaries, including 7 Universities and 1 Research Institute. The consortium will be managed by 5 different boards (research, managing, training, communicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Production of a new material: recycled and coloured polypropylen' (1998-2002).

assistant: **Innovation**

Recycled polypropylene has been on the market for a few years and it is not much used in the field of thermoplastic moulding yet. A high percentage of the market , that is all the companies manufacturing products that have important aesthetic functions, cannot use this new material. In fact, nowadays, the only colour available on the market is grey and different supplies of raw materials do not have an acceptable degree of colour uniformity.this projects aims at studying the method to obtain four different gradations of colour. During the first phase we will :1-develop and define a range of ral colours that can be obtained. The range of colours obtainable will have to be specified together with manufacturers of colouring additives for plastic ;2-carry out a market research in order to be able to find out the most fashionable and the most marketable colours (among those that are in the range selected). During the second phase :3 - we intend to carry out some practical tests on the basis of the colours selected adding new masters and aiming to achieve the looked-for gradations ;4-segis will check all the results and will give the final approval once the material is used in the products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SOftware Defined AppLication Infrastructures managemenT and Engineering'.

assistant: **Concept**

SODALITE will provide application developers and infrastructure operators with tools that (a) abstract their application and infrastructure requirements to (b) enable simpler and faster development, deployment, operation, and execution of heterogeneous applications reflecting diverse circumstances over (c) heterogeneous, software-defined, high-performance, cloud infrastructures, with a particular focus on performance, quality, manageability, and reliability. In doing so, it will produce several tangible results, (1) pattern-based abstraction library, including application, infrastructure and an absolute novum, performance abstractions, (2) design and programming model for full-stack application and infrastructure descriptions, using abstraction library; (3) deployment framework, enabling static optimisation of the so-abstracted applications onto specific infrastructures (4) automated run-time optimisation and management of so-deployed applications. This toolset will directly support Digital Transformation of European Industry through (1) increasing design and runtime effectiveness of software-defined infrastructures, to ensure high-performance execution over dynamic heterogeneous execution environments; (2) increasing simplicity of modelling applications and infrastructures, to improve manageability, collaboration, and time to market.


**Keywords:** performance-first abstraction, optimisation of IaC