RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Western Images of the Steppe Empresses. Literary and Film Portraits of Genghisid Women between Fascination and Fear (20th-21st centuries)' under Horizon Europe.

assistant: **Concept**

Since the Middle Ages, the name of Genghis Khan has been associated in the West with the idea of the Apocalypse. In accordance with this negative representation, the women who contributed to the rise of his empire have long been described as sinister witches and warriors, indistinguishable from the men of their horde. However, studies carried out starting in the last century, thanks to the opening of Mongolia to the West and the rediscovery of new local sources, have led Western scholars to a profound revaluation of Genghis Khan, now seen as one of the makers of the modern world. This revaluation has also affected our view of Mongol princesses, who enjoyed a freedom and a consideration unknown to their sedentary neighbors. Wise and resilient, they took part like men in war, politics and trade, and could choose whether and with whom to marry.  Western Images of the Steppe Empresses (WISE) is the first research in the field of comparative literature aiming to understand whether the new anthropological, archaeological, historical and philological studies carried out by the Mongolists have triggered a change in the perception of Genghisid female royalty in 20th and 21st century Western culture. It analyses their representation in American and Anglophone, Francophone and Italophone European literature and cinema. WISE seeks to understand the cultural reasons for the metamorphosis of the image in question, and whether it is connected to the changed role of women in the West as a result of feminist claims. Moreover, it explores the possibility of an Oriental influence, linked to the steppe culture, on the model of emancipated and combative women prevalent in the West today.   The training at Sorbonne Nouvelle University and the École Pratique des Hautes Études will give me the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The influence of stellar outflows on exoplanetary mass loss' (ASTROFLOW).

assistant: **Concept**

ASTROFLOW aims to make ground-breaking progress in our physical understanding of exoplanetary mass loss, by quantifying the influence of stellar outflows on atmospheric escape of close-in exoplanets. Escape plays a key role in planetary evolution, population, and potential to develop life. Stellar irradiation and outflows affect planetary mass loss: irradiation heats planetary atmospheres, which inflate and more likely escape; outflows cause pressure confinement around otherwise freely escaping atmospheres. This external pressure can increase, reduce or even suppress escape rates; its effects on exoplanetary mass loss remain largely unexplored due to the complexity of such interactions. I will fill this knowledge gap by developing a novel modelling framework of atmospheric escape that will, for the first time, consider the effects of realistic stellar outflows on exoplanetary mass loss. My expertise in stellar wind theory and 3D magnetohydrodynamic simulations is crucial for producing the next-generation models of planetary escape. My framework will consist of state-of-the-art, time-dependent, 3D simulations of stellar outflows (Method 1), which will be coupled to novel 3D simulations of atmospheric escape (Method 2). My models will account for the major underlying physical processes of mass loss. With this, I will determine the response of planetary mass loss to realistic stellar particle, magnetic and radiation environments and will characterise the physical conditions of the escaping material. I will compute how its extinction varies during transit and compare synthetic line profiles to atmospheric escape observations from, eg, Hubble and our NASA cubesat CUTE. Strong synergy with upcoming observations (JWST, TESS, SPIRou, CARMENES) also exists. Determining the lifet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Acquisition and regulation of epigenetic marks in mammals' in the context of a Sixth Framework call.

assistant: **Objectives**

Epigenetic mechanisms are essential in the programme of mammalian embryogenesis and postnatal development. Not surprisingly, therefore, their pathological deregulation can lead to human diseases and may be involved in cancer formation. A well-known epigene tic phenomenon in mammals is genomic imprinting, a mechanism via which certain autosomal genes show parental allele-specific expression. To accomplish this mono-allelic expression, imprinted genes present epigenetic marks ('the imprints') that are establis hed in either the male, or the female, germ line. These imprints are propagated from sperm, or egg, to the developing embryo, and are essential for imprinted gene expression, and hence, for normal development and health. Using the mouse as a model, the pro ject will unravel the nature of the imprints at the sequence elements that control imprinting ('the imprinting-control centres'). It will examine which features of the DNA sequences at imprinting-control centres are essential for the initiation of this pro cess. The Project focuses on the involvement of histone methylation at imprinting-control centres, and on methylation of CpG dinucleotides in the DNA. These epigenetic modifications will be investigated at representative imprinted loci, by coupling chromat in immuno-precipitation with bisulphite genomic sequencing, during the resetting and acquisition of the imprints in the germ cell lineage. Insights from these exploratory analyses will lead to tests for functional significance using transgenic approaches. This project complements and extends the researcher's experience in epigenetics acquired during his period of mobility. It will benefit both from the researcher's expertise in the analysis of DNA methylation in the germ line, and from the reintegration hos t'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early detection of emerging viruses by next generation in situ hybridization' (2007-2013).

assistant: **Innovation**

Europe is a recognized hotspot for emerging infectious diseases (EIDs). A total of 72% of zoonotic EID events have a wildlife origin. Those countries that conduct disease surveillance of their wild animal populations are therefore more likely to detect potential EID events at an early stage and to swiftly implement countermeasures. Detecting viruses in wildlife samples is currently done using serology, immunohistochemistry (IHC), or PCR among others. Although these techniques have their merits, they also have significant disadvantages: they either have a low specificity or require logistics that are not feasible or at best are difficult to apply in wildlife sampling. Although the proposed novel technique of in situ hybridization (ISH) has some shortcomings that have to be taken into account, it does not have these disadvantages. It provides an opportunity to profile multiple messenger RNA transcripts at a single cell level, and enables the detection of single-copy genes. As compared to PCR, ISH produces clinically relevant information regarding cellular and tissue context. Importantly, ISH can be applied to formalin-fixed, paraffin-embedded (FFPE) tissue sections, which easily can be transported and stored without biohazard or cold-chain constraints; this is a major advantage in wildlife disease surveillance. The objectives of this research are, first, to set up specific ISH techniques for the detection of viruses in FFPE tissues, including members of the families Asfarviridae, Bunyaviridae, Coronaviridae, Flaviviridae, Rhabdoviridae, Orthomyxoviridae, and Paramyxoviridae. This list is open-ended in case new viruses emerge in Europe. Second, to validate and use the ISH in a selected group of viruses and in real disease surveillance settings in the southern and eastern E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Capacity Building at InBIO for Research and Innovation Using Environmental Metagenomics' (EnvMetaGen) under Horizon 2020.

assistant: **Objectives**

The goal of the project is to expand the research and innovation potential of InBIO – Research Network in Biodiversity and Evolutionary Biology, through the creation of an ERA Chair in Environmental Metagenomics. The project aims to strengthen the research potential of human resources, lab facilities and next-generation genome sequencing equipment funded by a FP7 CAPACITIES project, supporting an emerging research line in environmental metagenomics for applications in biodiversity conservation, invasive species control, ecosystem services assessment, and environmental (bio)monitoring. The project will contribute to the regional and national smart specialization strategies, by developing tools and approaches to foster environmentally sustainable development, and strengthening innovation and knowledge transfer activities in close collaboration with local and global industrial partners, as well as with governmental agencies. In addition, the project will contribute to the advanced training of highly-qualified human resources, and to the communication, dissemination and exploitation of InBIO’s research and innovation. To achieve its objectives, EnvMetaGen will develop the following main activities: (i) Upgrade the research capacity and capability by expanding the human potential and fostering a critical mass of researchers with inter-disciplinary expertise in environmental metagenomics; (ii) Improve InBIO’s innovation potential and impact at the regional, national and European levels, by promoting the integration of cost-effective metagenomics approaches at the forefront of biodiversity, ecological and environmental research; and (iii) Raise the international and national network of collaborations and partnerships of InBIO and its industrial and governmental affiliates. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Detecting and Eliminating Bacteria UsinG Information Technologies' to be submitted under Seventh Framework.

assistant: **Abstract**

In about half a century of antibiotic use, unexpected new challenges have come to light: fast emer-gence of resistances among pathogens, misuse and overuse of antibiotics; direct and indirect re-lated costs. Antimicrobial resistance results in escalating healthcare costs, increased morbidity and mortality and the emergence or reemergence of potentially untreatable pathogens. In this context of infectious diseases we will (1) detect patient safety issues, (2) learn how to prevent them and (3) actually prevent them in clinical cases. We will detect harmful patterns and trends using clinical and operational information from Clinical Information Systems (CIS). This will bedone through the 'view' of a virtualized Clinical Data Re-pository (CDR), featuring, transparent access to the original CIS and/or collection and aggregation of data in a local store. Text, image and structured data mining on individual patients as well as on populations will learn us informational and temporal patterns of patient harm. This knowledge will be fed into a Medical Knowledge Repository and mixed with knowledge coming from external sources (for example guidelines and evidences). After editing and validating, this knowledge will be used by adecision support and monitoring tool in the clinical environment to prevent patient safety issues and report on it.Outcomes and benefits, both clinical and economical will be measured and reported on. Innovation within this project lays in the virtualization of Clinical Data Repository through ontology mediation, the advanced mining techniques, the reasoning engine and the consolidation of all these techniques in a comprehensive but open framework. This framework will be implemented, focused on infectious diseases, but will be applicable for all sorts of clin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Agent-Supported Workflow in public ADministration'.

assistant: **Objectives**

The goal of the project is to integrate existing free software tools to build a groupware system with built in workflow management and intelligent personal assistants for use in several distinct types of organisation within the public administration. The project will provide an important testing ground for the integration of free software solutions from three distinct areas: groupware, workflow management and agent technology. It will also enable public administrations to evaluate the use of flexible, free software solutions for their organisational needs, and provide the basis for ongoing pan-European cooperation in this area.Objectives:Technical objectives: to combine existing free software solutions to produce an integrated system to be tested in distinct types of organisation in the public administration. The technical objectives comprise:1. Providing a Unified Intranet Solution Based on Free Software: with integrated workflow management and intelligent personal assistants;2. Customising and Evaluating the Unified Intranet Solution.The business objectives comprise:1. Furthering the Free Software Service Industry;2. Furthering Free Software in Public Administrations.Work description:We will achieve our objectives in the following way:- Providing a Unified Intranet Solution Based on Free Software:- Groupware Functionality: we will use existing free software that has been developed for the Zope application server;- Customisable Workflow Management Functionality: we will integrate the Zope-based Open flow system with the groupware functionality;- Personal Assistant Functionality: we will port the Narval intelligent agent framework to the Zope application server and integrate it with the groupware and workflow functionality.- Customising and Evaluating the Unified Intran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From Villain to Antihero: She-Wolf in Old Norse Literature' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This project investigates the similarities between superhero narrative in modern popular culture and medieval Icelandic literature so as to (1) establish a viable theoretical framework based on current research on superheroes and (2) to apply it to a selection of medieval Icelandic texts that feature strong, politically powerful women who do not conform to conventional gender roles. The primary corpus will be drawn from the legendary and the chivalric sagas between ca. 1300 and 1600, which were composed under heavy influence of medieval French romances. Criteria will be established so as to define 'she-wolf' -- a concept drawn from both the Old Norse-Icelandic traditions of shapeshifting and fylgja and later chivalrid literature, and from the symbolism of wolf in European folklore that gave rise to Shakespeare's epithet 'she-wolf'. Based on the criteria, relevant characters will be classified into physical-visual, metaphorical-associative, and behaviourable she-wolves for further case-study based analysis. On the methodological side, this project constructs a spectrum based on character-types in superhero narratives: villain, anti-villain, and anti-hero, into which different categories of she-wolves will be analysed. A selection of post-medieval texts with roots traceable to the medieval materials will also be considered to highlight the motif's continuity and contemporary relevance.Overall, this project aims to bridge three academic fields -- medieval (literary) studies, medievalisms, and popular culture -- and shed lights not only on Old Norse-Icelandic literary motifs (such as the Maiden King and the supernatural elements) but also on the conceptualisationand representation of female, femininity, and issues of gender and ethnicity in the society that produced and enj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SYNERGIES BETWEEN SCIENCE AND SOCIETY FOR A SHARED APPROACH TO EUROPEAN SEAS' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

More than 70% of the globe is covered by water, and Europe itself is bordered by four different water basins (the Atlantic Ocean/North Sea, the Mediterranean Sea, the Baltic Sea and the Black Sea) which have been shaping and influencing the European cultural, social and economic heritage since the ancient times. Seas are the paradigm of cross-cutting approaches to knowledge and life. Oceans are appealing and fascinating which make them ideal tools for engaging and communicating with the public at large (irrespective of its age) even on otherwise complex, distant and themes.  4SEAS comes by a consortium mainly composed of science museums/aquariums and research centres located on the coasts of the 4 different European basins. Partners will act as single modules within a European network based on ITC technologies. 4SEAS will address all of the above through the following actions: 1) direct engagement of the public at large following a bottom-up approach to science communication; 2) selection of marine-related topics to be addressed by each partner taking into account both a shared/European and a specific/regional approach; 3) cooperation between science centres and science museums/aquariums to develop each topic and set up interactive exhibitions; 4) large use of ITC technologies to ensure connectivity in the network and open to the widest audience; 5) museum exhibitions and marine-oriented external events planned and made available directly or on the web. 4SEAS aims are: 1) to ensure visibility and dissemination of research results to the civil society; 2) to enable the public to express its views and concerns about science; 3) to promote science to the young; 4) to strengthen the European citizens’ sense of participation in Europe through their direct involvement; 5) to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The DNA damage response pathway in MYCN amplified neuroblastoma' (DDR-MYCN-NB) targeting Seventh Framework.

assistant: **Abstract**

Accurate replication of the genome is very important in cells to prevent the propagation of mutations which cause tumour development. After DNA damage, normal non-cancerous cells arrest the cell cycle in G1 to prevent cell growth until DNA damage is repaired or, if levels of damage are high, cells undergo programmed cell death. Stress responses leading to a DNA damage response stem from different sources and activate distinct pathways. However, they converge on the same components of the cell cycle machinery in the G1 phase of the cell cycle, namely the cyclin dependent kinases.  To investigate the mechanisms that MYC proteins affect the G1 checkpoint, we propose to use neuroblastoma with deregulated MYCN expression as a paradigm to examine the mechanisms that MYC proteins act on the DNA damage response pathway.  This DNA damage pathway is complex and acts in two main stages, an early inhibition of cyclin dependent kinase inhibitors by redistribution of p21WAF1 and a more sustained transcriptional response is mediated by p53. To appreciate the complexity of the DNA damage response pathway experimental data will be integrated with computer based mathematical modelling techniques to build a model of this pathway and how it is affected by deregulated MYCN expression. Understanding the effect of MYC proteins on the DNA damage pathway is essential for future advances in cancer treatments, as a large number of current chemotherapeutics are DNA damaging agents. This project will provide a general model for all cancer types driven by MYC proteins, it will also provide important prognostic indicators and new drug targets for the treatment of neuroblastoma- a cancer that accounts for 8% of all childhood malignancies where patients diagnosed with high risk neuroblastoma have a 5-y