RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mediating the Future: The Social Dynamics of Public Projections' (PROFECI) under Horizon 2020.

assistant: **Objectives**

People’s lives, both as individuals and at the collective level, are guided by projections about the future. This project aims to understand the complex processes through which projections about political issues, such as the outcomes and implications of elections, referenda, crises or wars, are formulated and negotiated within and through the media. It develops a new interdisciplinary approach and research tools for studying how projections evolve over time and through the contribution of various social actors (such as politicians, experts and journalists), and how they are received and acted upon by the public. The focus is on at least three retrospective case studies (projections about the Brexit referendum; the civil war in Syria; and Donald Trump's presidential bid) as well as three real-time case studies (to be selected based on geopolitical developments), characterised by high-visibility and involving projections with far-reaching implications. PROFECI integrates cutting-edge qualitative, quantitative and automated approaches to capture the interactive process underlying the construction and evolution of public projections, and their reciprocal relationship with people’s expectations and behaviour. It begins with an in-depth investigation of the construction, transformation and reception of projections made by key actors, using textual analysis of the source projections and their journalistic coverage, reconstruction interviews with experts and journalists, and focus groups with public members. The results of this stage inform the development of tools for a large-scale diachronic automated text analysis and panel surveys, which will be applied to the real-time and the retrospective case studies. By elucidating the life cycle of projections in a mediated environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Urban planning research actions to improve solar access, passive cooling and microclimate' (1994-1998).

assistant: **Innovation**

Objectives The main objective is to produce comprehensive design guidance on urban layout to ensure good access to solar gain, daylighting and passive cooling. The aim is to enable designers to produce comfortable, energy efficient buildings surrounded by pleasant outdoor spaces, within an urban context that itself aims to minimise energy consumption and the effects of pollution. Technical Approach The research phase will comprise a comprehensive integrated study of all solar and microclimate aspects of urban layout. In northern latitudes site layout is of particular importance, to avoid obstruction and overshadowing. Studies for winter solar heat gain and good daylighting will be carried out, including in existing buildings next to a new development. In southern European latitudes, shading and passive cooling become critical. Research to improve summer thermal comfort conditions will focus on solar protection of buildings and pedestrians, reduction of outdoor air temperature and wind enhancement. Monitoring of a range of sites in Athens will provide microclimatic data. Techniques like trees in urban design and passive cooling using fountains and sprayers will be considered. Wind tunnel studies of the dispersion of local pollutants to allow natural ventilation of buildings and improvement of the outdoor environment will be included. Design tool development will concentrate on extending the sophisticated TOWNSCOPE software to produce an integrated tool to model sunshine, wind and daylight in urban areas. Simple manual tools to evaluate loss of daylight, sunlight and solar gain due to obstructions will also be developed. The research will be backed by a series of case studies of urban areas, including two extended studies of Mediterranean sites. These are a new housing pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Identification of novel substrates for ubiquitin ligases involved in cell cycle and cell migration' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer cells heavily rely on the proteasome-ubiquitin system mediated tuning of proteins stability and proteome composition. Proteasome and ubiquitin ligases targeting drugs are already in use against certain haematological cancers, and similar inhibitors are currently explored as a possibility for autoimmune diseases and parasite infestation treatment. E3 ubiquitin ligases are the ultimate target for these therapies as they determine specificity in substrate recognition. It is thus of utmost interest for both basic and translational research to find new ubiquitin ligases essential for cell proliferation, cell migration or cancer progression and couple them with their substrates. In the proposed LIGER project, we aspire to fuse cutting-edge methods to identify new ubiquitin ligase – substrate pairs. In particular, we will focus on E3 ubiquitin ligases involved in cancer progression and more specifically, in its two crucial aspects - cell growth and cell migration. To pre-select the ubiquitin ligases for further analysis, we will perform an unbiased screen for ubiquitin ligases that are involved in cell growth and cell migration. To achieve this goal, CRISPR library screening methodology will be employed.  Consequentially, we will purify proteins associated with the selected ubiquitin ligases and identify their potential substrates. Standard biochemical and molecular biology methods will allow us to study in detail the protein interface between the ubiquitin ligases and their novel substrates and describe the biological function of their degradation. LIGER project will increase our understanding of ubiquitin pathway in physiological and pathological conditions and identify new potential targets for cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DARPin Targeted Magnetic Hyperthermic Therapy for Glioblastoma' (DARTRIX) under Seventh Framework.

assistant: **Objectives**

DARTRIX, ‘DARPin Targeted RX (therapy)’ is a multidisciplinary collaborative project that will develop high-affinity protein scaffolds to create a new generation of targeted therapeutics for the treatment of glioblastoma. There is great need; glioblastoma is virtually incurable and most patients die within 12 months of diagnosis. DARPins are small, non-immunoglobulin human protein scaffolds that bind specific targets with exceptionally high-affinity. DARPins are amenable to GMP production and to scale-up. They are remarkably stable, even  at high temperatures and they can be engineered to incorporate additional  favourable properties to target  glioblastoma cells with exceptionally high affinity. The new DARPins will be coupled to dextran-coated iron oxide nanoparticles, such as ferucarbotran or nanomag-MIP, which has been used clinically as a contrast agent for Magnetic Resonance Imaging (MRI). These ‘particles’ are  safe  to use  in patients and are traceable within the body. When stimulated by an appropriate alternating magnetic current, the particles generate heat that can kill cancer cells very effectively. The conjugation of DARPins with ferucarbotran or nanomag-MIP (DARTRIX particle) leads to a potent therapeutic by delivering targeted hyperthermia to glioblastoma. In addition, DARTRIX particle will be created economically, exploiting the fact that DARPins can be produced to GMP in gram quantities using E. coli. The DARTRIX particles will target  to glioblastoma cells by virtue of the high affinity and specificity of DARPins and the particles will remain  in place  when heated. By using DARPins to target the DARTRIX particle to tumour cells before application of the magnetic current, it should be possible to generate toxic heat specifically in the tumour. The con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'New therapies for myeloproliferative diseases based on multi-stage and -system analyses of the haematopoietic stem-cell niche'.

assistant: **Objectives**

Blood cells are produced in the bone marrow, which contains two distinct adult stem cell types: haematopoietic stem cells (HSCs), that generate all blood and immune cells, and mesenchymal stem cells (MSCs), thought to form the skeleton. HSCs traffic between bone marrow and circulation, what allows for life-saving clinical transplantation. Our previous work has shown that HSC numbers in blood are regulated by the central pacemaker in the brain, which reaches bone marrow nestin+ MSCs through the nerves. Contrarily to what it was believed, our recent data suggest that HSC-niche MSCs are different from those that form the skeleton and share instead a common origin with peripheral nerves and supporting glial cells. Thus, tight regulation of the bone marrow stem-cell niche in vertebrates might build upon developmental relationships of its cellular components. Moreover, we have shown that damage to this regulatory network is essential for the manifestation of myeloproliferative neoplasms, diseases that were previously thought to be driven solely by mutated HSCs. Also, JAK inhibitors (blocking the most frequent HSC mutation found in myeloproliferative neoplasms) cannot eradicate leukaemia stem cells. Our recent data has uncovered a selective regulation of normal and leukaemic haematopoietic progenitor maintenance, survival and division by sex hormones (oestrogens). These results might explain gender differences in blood cancer incidence and they also offer a new way of targeting leukaemia stem cells with clinically approved drugs. Nevertheless, we anticipate that the ideal future treatment of myeloproliferative diseases should target both leukaemia stem cells and their microenvironment. We have shown that protection or rescue of the niche is able to control the expansion of mut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Standalone solar-to-X device for prosumer-oriented conversion of sunlight to Ethene and Ammonia' (SOLEAS) under Horizon Europe.

assistant: **Objectives**

Solar photoreactors to produce fuels and chemicals via photo-induced processes are researched widely, but currently (i) lack harmonised interaction of material and reactor optimization , (ii) are not easily scalable  and (ii) may exceed sensible land areas for reasonable productivities , due to their rather low efficiencies in technical scale. In parallel, the reuse of biogenic CO2 from the biogas industry is among the most promising solutions to mitigate global climate warming while capturing nitrogen (N2) from the air – a readily available and abundant resource including 78 % of N2 –  is a viable feedstock for producing ammonia (NH3).SOLEAS develops a standalone solar-to-X device, converting sunlight and simple, low-energy molecules (H2O, CO2 and N2) in a multi-product approach into chemicals usable as either energy source or building blocks for  materials, precisely ethene (C2H4)  and ammonia (NH3) which have interesting crossing value chains, by means of:(a)breakthrough concentrator optics and quantum-dots deposition for solar wavelength adjustment;(b)optimized solar receiving side (parallel reactor internals for multi-reaction integration, unbiased anode-cathode development, zero gap design with optimized fluid dynamics and in-situ product outtake.With its multi-product approach SOLEAS enables the realisation of several photo-reactions in one device enabling simplified production chains where one directly goes from simple feedstock to complex products, beyond hydrogen or carbon monoxide.The device will be able to operate independently, allowing, in the long-term, communities and remote areas to have access to reliable and sustainable energy sources and a local production and utilization of chemicals and fuels.The developed device will reach TRL 5-6 within a 4-year
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Effects of Far-Right Challenges on International Organizations' to be submitted under Horizon Europe.

assistant: **Abstract**

The rise of the far right poses a profound challenge to global politics. Diverse far-right actors, such as political parties, civil society groups, and social movements, have been gaining support in domestic contexts, while intensifying their transnational contacts. As these groups focus on national sovereignty and share a stance against globalization, they often contest international organizations (IOs) and their policies. Yet their impact on international organizations differs: On the one hand, far-right groups have profoundly changed negotiations on the Global Compact for Migration in the UN. On the other hand, radical-right parties in the European Parliament have hardly brought about any deeper policy changes. Why does transnational far-right contestation have varying effects on international organizations?While scholars have analyzed far-right actors in domestic politics, knowledge about their transnational activities and effects is limited. FARRIO fills this gap empirically, theoretically, and methodologically. Empirically, it compares effects of far-right contestation on the EU, the UN, and its specialized agencies/treaties in four central policy fields (migration, women's rights, climate change, and public health). Theoretically, it proposes that IO changes depend on the directness of far-right strategies and the liberal character of international organizations. It thereby breaks new ground in identifying scope conditions for far-right impact highly relevant for research on transnational protest as well as IO resilience and change. Methodologically, FARRIO draws on and further develops quantitative and qualitative methods. It adapts protest event and networks analysis to map transnational far-right contestation, also including social media data. Bridging Compara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GReener Aeronautics International Networking-2' under Seventh Framework.

assistant: **Concept**

As mentioned in the Executive Summary of the Strategic Research & Innovation Agenda, Aviation has an important role to play in reducing greenhouse gas emissions as well as noise and local air quality issues. The continuous increase of air passenger transport generates an increasing use of hydrocarbon fuel with excessive emission of CO2 and NOX (greenhouse gases, pollutants and noise). It is well known that commercial aircraft operations impact the atmosphere by the emissions of greenhouse gases and greenhouse gas precursors, and also through the formation of contrails and cirrus clouds. In 2011, during the Aerodays in Madrid, the EC launched the future of Aeronautics in the ACARE Flight Path 2050 Vision for the Aircraft report containing the ambitious goals on the environmental impact with 90% reduction in NOx emissions, 75% reduction in CO2 emissions per passenger kilometer, and the reduction of the noise in by 65%, all relative to year 2000.To achieve the ACARE Strategic Research & Innovation Agenda green aeronautics technologies will play a more and more dominant role in mastering the challenge on “Protecting the environment and the energy supply”. GRAIN2 Supported Action, based on the same collaborative and win-win spirit introduced in former EU-China GRAIN project, will provide inputs and roadmaps for the development of large scale simulation strategies for greener technologies to meet the above future requirements on emissions, fuel consumption and noise. To reach these targets, green technologies efforts will have to be collected and prospected in three major lines: Air vehicle, Air Transport System and Sustainable Energies. Three folds to be investigated as future greening technologies:1) Greening the aircraft and the aero engine2) Greening the operational envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Impact of cryptic rhizosphere plasmids on the molecular interactions between bacterial populations and crops' to be submitted under Seventh Framework.

assistant: **Abstract**

The competitiveness of Europe in the field of sustainable agriculture programs has been drastically compromised due to a serious drift of academic expertise on the development of novel inoculants away from Europe’s to major USA Agricultural companies where the multidisciplinary skills required for this work is available in single institutions. ERA is therefore at serious risk of becoming non-competitive with North America where there is critical mass and excellent training in this area. To regain the European leadership in this field there is an urge to generate a critical mass of scientific workforce with the required advanced multidisciplinary training. The research project will use Sinorhizobium meliloti as a model bacterium used in inoculums and will investigate, at the molecule level, the role natural cryptic self-mobilisable plasmids from plant associated rhizobacteria have on the interactions between these bacteria and crops with a view to design novel inoculums that can be used for sustainable agriculture. This IEF project is highly complementary to the applicant’s existing research skills and her extensive knowledge on advanced technologies for the study of bacterial molecular genetics, protein-target interactions and bacterial gene transfer will, in return, bring new expertise to the University of Nottingham. This type of project cannot be achieved with the expertise of a single institution but can be attained through establishment of this IEF fellowship for advance complementary multidisciplinary training where both the host institution and the visiting fellow will benefit from the exchange of expertise. The topic has been freely chosen by the fellow in collaboration with the host institution with the aim to maximise her employability, competence diversificat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards gene therapy using Bifidobacterium as gene delivery system' under Sixth Framework.

assistant: **Concept**

The main objective of this project is develop an efficient expression vector for Bifidobacterium, that allow the use of these bacteria as non-viral gene delivery system of prophylactic and/or therapeutic substances in the human intestine or into tumours, eliminating the bottleneck that the lack of this new innovative molecular tool is producing to underpin applications to human health using these probiotic GRAS status bacteria included in the lactic acid bacteria group. The expression vector of this project will be designed to permit an easy molecular manipulation and cloning, for the systematic study of the expression elements that can affect the expression in Bifidobacterium of proteins of prophylactic and/or therapeutic interest, allowing standardisation and characterisation in gene therapy using Bifidobacterium. These studies could elucidate which factors are important to increase the amount of protein expressed or to obtain a temporal control of the expression, crucial factors for some therapeutic applications, permitting the optimisation of the expression vector for each protein and therapeutic application. To corroborate the functionality and cell targeting versatility of the expression vector constructed in this project, and for validate the feasibility of Bifidobacterium as gene delivery system using this vector, are also objectives of this project study the therapeutic effect of the expression of two different therapeutic proteins the cytokine interleukine-10 and the angiogenic peptide endostatin, that must been expressed and delivered in two different localisation to show their therapeutic effect, gut and tumours respectively. These studies will be carried out using animal models of the human Inflammatory Bowel Disease (IBD) and tumours respectively. In the c