RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reliable Novel Liquid Biopsy technology for early detection of colorectal cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall aim of LIQBIOPSENS project is the further development and validation in real settings of a novel diagnostic platform for the early and fast detection of ctDNA and their KRAS and BRAF mutations associated to colorectal cancer through blood samples. The main features of LIQBIOPSENS are: reliability (detection rates vary from 95–100 %), low-cost (40-50 € per sample analysis), sensitivity (in the zM range), multiplexing capabilities (analysis of 27 KRAS and BRAF mutations simultaneously), short analysis time (30-60 min.), user-friendly interface and flexibility. Solution proposed by the LIQBIOPSENS project relies on the multidisciplinary integration of different Key Enabled Technologies: microelectronics, microfluidics, nanomaterials and genomics. In particular, LIQBIOPSENS platform is based on the integration of two novel complementary technologies. On the one hand, the revolutionary DGL© technology property of DestiNA Genomics Ltd, capable of delivering faster, more error-free detection of nucleic acids and their mutations than current enzyme-based detection systems, making 'false positive' results a thing of the past. On the other hand, a novel high resolution acoustic wave microsensor technology property of AWSensors, that allows an accurate, inexpensive, label-free, direct and real time transduction method to quantitatively evaluate the results of the application of the above mentioned DGL© technique.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design, development and manufacturing of an electro-mechanical actuator and test rig for AiRcrafts Main LandIng Gear acTuation systems.""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The ARMLIGhT project will design, manufacture, tune and validate an innovative and smart Electro-Mechanical Actuator for the study and validation of a future complete all-electric landing gear actuation system. ARMLIGhT actuator will be based on a modular and efficient approach that will integrate easily exchangeable electric and mechanical components with sensors and control strategies that will allow automatic and autonomous safety control.The ARMLIGhT Electro-Mechanical Actuator will include its dedicated Electronic Control Unit, a Built In Test equipment to detect potential failures and a disable device to guarantee compatibility with emergency actuation. Different configurations will be studied and evaluated to determine the optimum system architecture from a technical point of view. Volume, mass, electrical consumption, power to mass ratio, reliability, durability and safety are concepts that will drive the development.The ARMLIGhT system will be tested and validated at several stages: Virtual validation at model level and finally actual experimental validations of the complete system through both on-ground and in-flight test campaigns. These sequential and complementary validations will assure thus a reliable, safe and efficient performance of the prototype and will provide data for a deep concept evaluation.For this validation purpose, the ARMLIGhT project will also design, manufacture and tune a Test Rig for ARMLIGhT Electro-Mechanical Actuator validation. ARMLIGhT Test Rig will allow installation both in Copper Bird® and in the ATR (Avions de Transport Regional) passenger cabin. The test bench will also include its own control system, inertia load simulation of the Main Landing Gear involved weight and counter-load actuator with its hydraulic and electric powe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Neural Circuits Enabling Navigational Simulations' to be submitted under Horizon Europe.

assistant: **Abstract**

One of the most notable features of the brain is the ability to simulate possible consequences of a behavioural choice that has not even been experienced in the real world. While this ability is likely fundamental for our intelligence and creativity, its neural circuit basis is largely unclear. To tackle this problem, we will focus on the rat’s ability of spatial navigation, finding an optimal path to a remote destination that is located outside the range of sensory perception. This ability is thought to be supported by the brain’s internal map that allows an animal to estimate its future position followed by planned movements. While the hippocampal formation has been the primary focus of research on the brain’s spatial map, it mainly tracks an animal’s position and its nearby trajectories. By contrast, the brain has another internal map in the orbitofrontal cortex (OFC) that points to an animal’s goal destination throughout navigation. Because this goal coding emerges autonomously in the network without relying on explicit external cues, it can be considered part of the brain’s inner reasoning process for future behaviours. Here we will explore how this internally-set goal can emerge in the OFC network through interactions with its associated regions – thalamus and neuromodulatory systems. We will then explore how this goal coding can be used to plan an optimal goal-directed path by avoiding known obstacles in the environment. Since this process likely requires the cooperation of two internal maps in OFC and the hippocampus, we will elucidate the underlying circuit mechanism that employs multiple map systems in parallel. We will take advantage of state-of-the-art experimental and analysis techniques to decipher neural codes for navigational simulations. The OFC and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigation of a new strategy for the controlled-release of drugs from bioresorbable inorganic matrices'.

assistant: **Concept**

Although extensive research has been carried out in the past few years to develop strategies for controlling the release of highly toxic therapeutic agents (such as cancer drugs) in the body, most drug-delivery systems still produce unsatisfactory results in vivo. The overall goal of this work is to tackle two of the main drawbacks of current devices,1- by favouring the release of the drugs via a well-known mechanism (i.e. the breaking of well-defined bonds which will have been created between the therapeutic molecule and the drug-carrier matrix), and2- by using inorganic drug-carrier matrices selected for their bioresorbability.In this project, the study will focus on a subset of purposely chosen systems (drugs with a phosphonic acid or boronic acid function), in order to reach the following key targets:1- the synthesis and complete structural analysis of materials in which a drug is linked via well-defined (iono)covalent bonds to a bioresorbable inorganic matrix,2- the measurement of the reactivity and stability of these (iono)covalent bonds in vitro, and the understanding of their sensitivity to various parameters (pH, temperature, rate of degradation of the carrier matrix…).In the long term, this work should open the way to new strategies for the rational elaboration of efficient drug-delivery systems.The project is expected to significantly boost the research career of the applicant, by allowing her not only to combine the various skills she has acquired during her PhD and post-doc, but also to acquire new competences in the multidisciplinary field of drug-delivery biomaterials. She will find at the Institut Charles Gerhardt in Montpellier both the scientific expertise and equipment necessary to carry out this work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Postdoc to research LEADer programme' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The competences for performing top-level research and research leadership is growing in complexity. There is a demand for creative, interdisciplinary and innovative researchers, led by open, inclusive and collaborative research leaders. This requires a new and dedicated approach for strategic career development, especially in the transition from research talent to research leader. The ‘postdoc to research LEADer programme’ will address the individual needs of 16 talented researchers, holding a PhD degree followed by 2-5 years of research experience. Our VISION is to empower the fellows to become the next generation of creative, critical, open, collaborative, responsible and inclusive research leaders, in or outside academia. The Biotech Research and Innovation Centre (BRIC), University of Copenhagen is a centre of excellence in biomedical research, aiming to offer outstanding research training. BRIC will together with several partner organisations TRAIN, NURTURE and CHALLENGE the fellows to develop an individual researcher and research leader profile. LEAD will offer the fellows attractive employment conditions and 3-year contracts with BRIC. The recruitment will be based on transparent, merit-based selection, involving external experts from academia and industry, ensuring selection of diverse talent. Our AIMS are to 1) Ensure transparent merit-based selection, 2) ensure a supportive framework for conducting transformative, interdisciplinary biomedical research, 3) support development of excellent research leadership competences and transferable skills and 4) support the researcher’s strategic career development according to individual goals. LEAD will equip the fellows with excellent research abilities, strong leadership competences and a broad transferable skills-set,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Training Network for Zero-waste Valorisation of Bauxite Residue (Red Mud)' (REDMUD) targeting Horizon 2020.

assistant: **Abstract**

To tackle its (critical) raw material dependency, Europe needs comprehensive strategies based on sustainable primary mining, substitution and recycling. Freshly produced flows and stocks of landfilled industrial residues such as mine tailings, non-ferrous slag and bauxite residue (BR) can provide major amounts of critical metals and, concurrently, minerals for low-carbon building materials. The European Training Network for Zero-Waste Valorisation of Bauxite Residue (REDMUD) therefore targets the vast streams of new and stockpiled BR in the EU-28. BR contains several critical metals, is associated with a substantial management cost, whereas spills have led to major environmental incidents, including the Ajka disaster in Hungary. To date, zero-waste valorisation of BR is not occurring yet. The creation of a zero-waste BR valorisation industry in Europe urgently requires skilled scientists and engineers, who can tackle the barriers to develop fully closed-loop environmentally-friendly recovery flow sheets. REDMUD trains 15 researchers in the S/T of bauxite residue valorisation, with emphasis on the recovery of Fe, Al, Ti and rare earths (incl. Sc) while valorising the residuals into building materials. An intersectoral and interdisciplinary collaboration of EU-leading institutes and scientists has been established, which covers the full value chain, from BR to recovered metals and new building materials. Research challenges include the development of efficient extraction of Fe, Al, Ti and rare earths (incl. Sc) from distinct (NORM classified) BRs and the preparation of new building materials with higher than usual Fe content. By training the researchers in pyro-, hydro- and ionometallurgy, electrolysis, rare-earth extraction and separation technology, inorganic polymer an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Near-Infrared Photothermal Nano-CAR Immunotherapy mediated by engineered exosomes targeted to pancreatic cancer with mutated KRAS'.

assistant: **Objectives**

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a 5-year survival rate under 10%. Current treatments for PDAC are based on ineffective and unspecific drugs that cause hard side effects. Besides, new T cell-based immunotherapies are toxic and unsuccessful in most solid tumors, including PDAC. Activating KRAS mutations occur in almost all patients, but unfortunately, KRAS is difficult to target. This discouraging situation highlights the need to design orthogonal and innovative strategies that target different pro-tumoral axes, in order to increase the antitumor effect minimizing side effects. In NIR-NanoCAR project, we will develop a new concept of therapy, Near-Infrared (NIR) Photothermal Nano-CAR Immunotherapy (NIR-PNCI). To test this concept, we will fuse i) thermosensitive liposomes capable to mediate photothermal therapy by NIR, with ii) exosomes derived from mesothelin-CAR T cells armored with IL-12 (which maintain effector molecules from their parental cells) and loaded with siRNA targeted to mutated KRAS. We will explore the antitumor capability and the tumor microenvironment-reprograming mediated by the hybrid nanotherapy in a relevant murine PDAC model. If successful, this nanosystem will be a breakthrough with a paradigm shift in the strategy to design the next generation of nanoimmunotherapies for solid tumors.


**Keywords:** Exosomes, liposomes, Immunotherapy, Nanomedicine, CAR.T cells, mutated KRAS, pancreatic cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'INNOVATIVE MARKETING STATEGIES FOR CHEESES WITH PROTECTED DESIGNATION OF ORIGIN' (1994-1998).

assistant: **Concept**

Cheeses with Designation of Origin (DO) are produced in defined geographical areas according to specific conditions of manufacture and ageing. Their characteristics are subject to variability influenced by seasonal variations and small-scale production plants. In Europe they represent the possibility of maintaining economic activity in rural areas with the promotion of the local factors.These traditional products have to face the rapid changes in the market which require concentration of supply, standardisation of composition, packaging innovation and aggressive communication campaigns. Furthermore, with the enlargement of the market beyond the territory of origin and the national boundaries, cheeses with DO have to face the competition of imitating products at low price which tend to reproduce some of their aspects. The organisations which administer the DO invest most of their budget in communication and marketing programmes aimed at providing information on the typical characteristics of their cheeses at local, national, international level. The techniques available for these actions, however, are more appropriate for commercial brands than for DO's. Therefore it is necessary to study the forms of communication and marketing suitable for these products in order to give the correct perception to the consumers about the quality aspects defined with the DO. In this respect it is also important to establish new relations with the distribution interested in differentiating and riappropriating a professional image typical of the traditional store. This would mean the perpetuation of the multidimensional consumer-producer agreement symbolised by the DO, the promotion of territorial management and respect for the environment. Through a series of plenary sessions, workshops a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards early cancer detection and tumor classification using epigenomic biomarkers in blood' (EpiCblood), addressing dissemination and exploitation.

assistant: **Impact**

Early cancer detection could increase curative treatment and long-term survival. Dying cells release small DNA fragments wrapped around a core of histone proteins into the bloodstream, so-called circulating cell-free nucleosomes (cf-nucleosomes). They carry DNA sequence information and histone modifications stable in blood, reflecting promising epigenomic disease biomarkers. But, the low proportion of cf-nucleosomes originating from cancerous cells versus the large background of nucleosomes arising from dying blood cells poses significant challenges for early cancer detection using circulating cf-nucleosomes. In EpiCblood, I will tackle these challenges and propose two complementary strategies to increase the number of cancer-signature cf-nucleosomes for cancer detection and tumor classification. In the first strategy, I will employ my previously developed synthetic histone modification readers to profile abundant histone modifications on cf-nucleosomes allowing me to seize up to 35 percent of the human genome non-invasively. I will prove this technologys concept by detecting earlier stages of pancreatic cancer and simultaneously classifying molecular tumor subtypes. Furthermore, I hypothesize that tumorigenesis gives rise to cancer-specific genomic sites decorated with combinatorial histone marks, so-called bivalent regions, found explicitly in cancer and not in healthy adult cell types. In the second strategy, I will employ a computational pipeline to map cancer-specific bivalent sites across multiple cancer genomes. I will use my well-established combinatorial histone mark readers to test their diagnostic potential as cancer-specific biomarkers in blood plasma from healthy donors and cancer patients. My genomics expertise and proven technology provide an excellent ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Immersive Audio Rendering and Transmission Technologies' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In recent years, there has been great interest towards the transmission of digital audio in real time, especially through wireless networks. A significant application is digital audio broadcasting, a technology considered as the evolution of today's radio, which will provide the listener with a truly enveloping listening experience. At the same time, multichannel audio systems are considered as the next step in audio reproduction. The current 5.1 setting is expected to be enhanced by even more channels, possibly leading to the 10.2 system, which will be able to offer a completely immersive audio environment. The associated increase in the information content of the audio stream will directly affect the transmission of this medium. We propose techniques that can significantly reduce the transmission requirements of multichannel audio regardless of the number of channels that are transmitted. Our approach takes advantage of the inherent similarities of multiple audio channels. It is novel in that it derives additional channels from the information contained in just one or two signals in order to recreate the signals at several virtual" microphone locations, based on previous knowledge of the acoustical characteristics of the venue. Moreover, in this project we will attempt to increase the transmission rate that can be achieved by the current systems of digital audio broadcasting. We propose the use of array signal processing methods by employing adaptive antennas for wireless transmission of sound. We will develop methods that enhance the current OFDM (Orthogonal Frequency Division Multiplexing) scheme and will allow for quality scalable audio transmission by combining array processing with unequal error protection and layered coding."