RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Lighthouse for Atlantic and Arctic Basin' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The EU has set bold quantified and measurable targets to achieve its Ocean Mission objectives relating to protecting and restoring marine ecosystems and biodiversity (Mission Objective 1); preventing and eliminating pollution of our ocean (Mission Obj. 2); and making the sustainable blue economy carbon-neutral and circular (Mission Obj.3) by 2030. The EU Mission Implementation Plan has two demanding, but necessarily near-term phases: the first ‘development and piloting’ phase by 2025,  and the second ‘deployment and upscaling’ phase from 2026-2030. PHAROS will be the logical stepping stone bridging Mission Phase 1 ‘development and piloting’ and the second ‘deployment and upscaling’ phase from 2026-2030.•PHAROS will have three demos in the Atlantic using a combination of newly developed innovative NBS and IMTA, tailored to the local context, resulting in multiple biodiversity and ecosystem restoration benefits (Mission Phase 1). These demos will also leverage key Mission projects including Ocean Citizen, Climarest, and Ultfarms (Mission phase 2). •PHAROS will also partner with H2020 ECOTIP to leverage and extend its project in a demo  to reduce invasive species in Iceland with eDNA monitoring (Mission phase 1 and 2).•PHAROS will extending (TRL advancement) and rolling out leading Mission projects across the AA basin including Prep4Blue MPA platform and network, Nettagplus and Remedies Fisher Guardian and Citizen Litter Entrepreneur programs, and Probleu EU Blue School Network platform for education(bridge to phase 2)PHAROS will establish Living Labs, early in the project in each demo and replication region, securing participation for its co-creation approach, across all relevant and necessary actors including different levels of government, researchers and innovators, ed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biodiversity: Applied and Systematic Investigations of Cyanobacteria' (1994-1998).

assistant: **Concept**

The cyanobacteria are a phylogenetically coherent taxon of oxygenic phototrophic prokaryotes whose range of morphological diversity is greater than that of any other group of microorganisms. They represent a unique source of biodiversity for both fundamental and applied research but previous difficulties encountered in their culture, axenization and systematics have prevented thorough study of their potential. With the first two problems largely overcome, this project proposes a timely investigation of cyanobacterial systematics (employing phenotypic, genotypic, physiological and biochemical characters), a search for compounds of biotechnological interest, and a study of species diversity in the natural environment. The project will be based on the 600 axenic strains available in the Pasteur Culture Collection of Cyanobacteria (PCC) and is composed of three work packages. I. Biosystematics: comparative approaches for definition of taxa. A characterization of the phenotypic and physiological properties of cyanobacteria will involve: cellular morphology and differentiation; photosynthetic pigments; physiology (heterotrophic potential, N2 fixation, temperature maxima, salt tolerance); biochemical constituents (lipids, fatty acids, carotenoids, exopolysaccharides). These studies will be complemented and extended by high resolution molecular techniques applied to total genomic DNA (determination of molar G+C content and genetic complexity, DNA-DNA hybridization, DNA fingerprinting with RFLP and RAPD) or to individual genes (restriction pattern analysis following hybridization to specific probes). Protein fingerprinting will be performed by electrophoretic separation of total or soluble proteins. Phylogenetic analysis will employ the sequences of 16S rRNA and the intergenic t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Noninvasive Monitoring of Blood Flow and Oxygen Dynamics as Biomarkers in Cancer Tumours', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cancer is one of the leading causes of death in the world, taking an enormous toll on the society.  Early detection is paramount for effective treatment. Afterwards, to individualize and optimize the treatment regime, it is increasingly becoming evident that early and frequent monitoring of the evolution of the tumour physiology in response to treatment is needed.  Optical tools are emerging as promising modalities to this end. We will take advantage of this ability to carry out a pilot study to investigate the possibility of extending the use of diffuse optical methods to aid thyroid cancer characterization and therapy monitoring. Thyroid nodules are very common (~27% in adults) and a considerable amount of these, about 5%, develop into cancers. Unfortunately, the sensitivity and specificity of currently used technique for detection of potentially malignant nodules, thyroid ultrasound (US)-guided biopsies, is poor, making diagnosis and treatment difficult. We believe that optical methods will improve this. Furthermore, malignant tumours usually attract the formation of new and chaotic blood vessels via a complex process called angiogenesis. This has been exploited by the development of numerous treatment methods that rely on the inhibition of angiogenesis. However, it has also been observed that despite initial successful inhibition of angiogenesis, tumours may adapt and regain angiogenesis so that they can grow again. We will investigate this onset of tumour resistance by developing a novel, new 3D optical scanner for diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) in mouse models. If we are successful, we would advance the frontiers on basic understanding of cancer biology and explore new clinical applications of optical technologies.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mobility Environmentally-friendly, Integrated and economically Sustainable Through innovative Electromobility Recharging infrastructure and new business models' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

MEISTER will deliver a set of  tools to foster e-mobility large scale adoption by (1) demonstrating innovative, sustainable business models to lower installation and operation costs of charging infrastructure, (2) optimizing usage of infrastructure by the smart combination of charging and parking services, (3) integrating EV within urban SUMPs, including the establishment of EV sharing and the inclusion of EV within MaaS schemas to reduce CO2 emissions and optimize urban space usage, (4) providing interoperable platforms and services to users for an easy, convenient and barrier-free access to charging, billing and smart grid services, including an increase of the use of RES and self-generation to power EVs. Thus, MEISTER aims at creating the conditions for smart e-mobility market take up in cities, by means of developing integrated approaches, smart solutions and innovative, sustainable business models, which will be tested and validated in three urban areas in Southern, Central and Northern Europe: Malaga (Spain), Berlin (Germany), and Gothenburg (Sweden). These 3 sites are EU leaders in the field of e-mobility, have complementary contexts and share a common vision on EV deployment. The three MEISTER pilots will involve 51,500 users, 1,000 EV and 660 charging points.MEISTER expects to increase by 15% the demand for EVs, as well to reduce by 20% the installation costs of EVSE infrastructure. At the same time, the project expects to help reduce charging prices by 20% and increase by 30% the usage of RES to charge EVs. As a result of these figures, the project will also have a substantial impact in terms of a reduction of emissions and environmental sustainability, as described in section 2.1.4. Business models and public-private partnership frameworks developed and demon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Energy ManagEment and RechArging for efficient eLectric car Driving'.

assistant: **Innovation**

EMERALD focuses on energy use optimisation and on the seamless integration of the FEV into the transport and energy infrastructure, by delivering clear advances over the state-of-the-art. The goal is to assist the FEV in becoming a successful commercial product.To this end, EMERALD will innovate a range of novel ICT solutions, each one seamlessly integrated with the others, providing a multifaceted and comprehensive approach on these issues. EMERALD will introduce Integrated in-vehicle energy management, comprising:\tDynamic energy-driven management of FEV auxiliaries, tightly integrated with consumption prediction functionality, enabling pre-emptive energy conservation measures.\tEnergy-efficient long-range route planning and optimisation, enabling extension of FEV's driving range and automatic scheduling of recharging stops en route.\tPerformance-centric machine learning for consumption prediction, introducing optimisation and cooperative training of machine learning functions targeted for energy consumption and traffic prediction based on experience.\tDriver profiling functionalities, through monitoring of acceleration/braking patterns, for the enhancement of route consumption prediction functionality.\tV2G traffic and consumption data synchronisation, as a new cooperative information-sharing scheme.\tUser-centric charge and discharge management, enabling automatically-generated, optimal for the user, charge and discharge schedules, accessible both on-board and on his mobile phone.EMERALD will also introduce: Enhanced FEV-related power demand prediction and power flow management support, taking advantage of consumption patterns as shared in a cooperative manner by the FEVs themselves, as well as from FEVs' recharging bookings; Cooperative FEV fleet management,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Causal Structuralist Ontologies in Antiquity: Powers as the basic building block of the worlds of the ancients'.

assistant: **Innovation**

The project aims to bring about a paradigm shift in our understanding of how the ancients conceived of the universe and its contents over a period of 9 centuries, 600 BC to 300 AD. The driving research hypothesis is that the sole elementary building blocks of nearly all ancient ontologies are powers, from which all there is in the universe is built. Powers are relational properties which are directed towards an end (e.g. the power to heat); thus a world of powers is structured in a web of causal relations. What is revolutionary about such a world is that there is only structure in it; hence, causal structuralist ontologies underlie object-metaphysics or process-metaphysics, and worlds of being and becoming, supplying structures from which objects and processes are derived. Yet such ontologies have never been investigated about ancient thought.The project’s topic is new: ancient causal structuralism; the speciality is novel too, requiring targeted training of a team of post-doc researchers which will be provided by the applicant and collaborators. The innovativeness of the methodology consists in training ancient philosophy researchers to discern and identify formal aspects of ontologies at the very roots of human rationality – discerning how the ancients built everything out of power structures.The paradigm shift will generate new knowledge and understanding about the ancient accounts of the world; provide a heuristic vantage point for redrafting the map of the intellectual influences between ancient thinkers; stimulate fruitful debate; and inspire new insights into ancient thought that are literally unthinkable at present. Cognate disciplines that will be affected by the paradigm shift are such as: history of physics; of mathematics; of theology; ancient anthropology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Approaching Synapses with Nanoscale Aptamer-Based Biosensors' to be submitted under Horizon Europe.

assistant: **Abstract**

“Given the complex, and multifactorial nature of neurodegenerative pathophysiology, strategies aimed at the synapse could provide a useful addition to the therapeutic toolbox” – this quote by B. Dejanovic et al. published in Nature Reviews Drug Discovery this year, highlights the critical need for innovative tools to probe synaptic function. Synapses, where neurons communicate, are tightly regulated by astrocytes, which manage their energy needs (neuroenergetics). Astrocytes shuttle neuroenergetic molecules (e.g., glutamine, lactate, and adenosine) to meet energy demands. Disruptions in these astrocyte-mediated pathways are now recognized as common features in neurodegenerative disorders, suggesting that impaired neuroenergetics may be at the origin of such diseases. Understanding neuroenergetics is crucial for developing therapies that target the root cause of neurodegeneration, not just its symptoms.SYNAPTA aims to fill this gap by developing nanoscale biosensors that detect multiple neuroenergetic molecules at synaptic dimensions. To achieve this ambitious vision, we will: 1) isolate receptors (DNA aptamers) that reversibly capture neuroenergetic molecules, 2) create a library of DNA aptamer-based biosensors with ~10 nm spatial resolution, 3) design multiplexed sensors, 4) integrate these biosensors into scanning ion conductance microscopy (SICM) and electrophysiology platforms to enable 5) high-resolution, real-time chemical and electrical mapping of synaptic activity. This system will enable millisecond recordings of neuroenergetic molecules at <10 nm resolution, surpassing current technologies. Led by my multidisciplinary expertise in aptamer discovery, chemical biosensing, and neural interfaces, SYNAPTA will consolidate these fields to uncover how astrocyte-neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regulation of cell growth and division by selective degradation mechanisms' (RUBINET), addressing dissemination and exploitation.

assistant: **Impact**

Cell growth and division are tightly regulated by phosphorylation and selective degradation of cellular components. Whereas autophagy is mainly responsible to eliminate long-lived proteins and organelles, the ubiquitin-proteasome system (UPS) rapidly degrades proteins when fast adaptation is needed. Defects in these degradation systems accounts for numerous human diseases, including cancer, muscle dystrophies, viral and bacterial infections and neurodegeneration. While rapid progress has been made in the identification of UPS and autophagy components, little is known about their regulation and the molecular mechanisms that ensure substrate specificity. We therefore propose an interdisciplinary combination of biochemistry, cell and structural biology, genetics, RNAi-screening, quantitative microscopy and microfluidic technology to tackle these questions in yeast and mammalian cells.E3 ubiquitin ligase complexes are important UPS components that specifically bind substrates via dedicated adaptors. In particular, cullin-based E3-ligases control cell growth and division, but much needs to be learned about their regulation and the identity and function of their key substrates. Moreover, we uncovered a function of RING-H2 E3-ligases in MAP-kinase networks, providing a new link between phosphorylation and the UPS. Finally, while autophagy can selectively remove protein aggregates and damaged or excess organelles, the underlying mechanisms that provide specificity to this process are poorly understood. Recent evidence suggests that ubiquitin may also serve as a recognition signal for selective autophagy. We will thus investigate the roles of ubiquitin and specific autophagy substrate-adaptors, and focus on the molecular crosstalk between selective autophagy and the UPS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of silicone sealants curable by U.V. radiation' (SERU).

assistant: **Concept**

New developments of silicone sealants curable by ultraviolet radiation, and also new photoinitiators modified by sylanization have been obtained. Actually, there are very few silicones curable by ultraviolet radiation in the market, and their applications do not include the construction field. The photopolymerization technique is very important to obtain the desired properties. The selection of the lamps and the photoinitiator is crucial for the development of the new silicone sealants. According to the kind of silicone, transparent or pigmented silicones, the lamps and the photoinitiators most suitable have been selected. The obtained properties vary according to the kind of silicones. In general the obtained cure depth is greater for the transparent silicones than for the pigmented ones. The cure depth varies according to the used lamp, the selected photoinitiator and the acrylated silicone content. According to the raw materials selected for the formulation the characteristics of the silicone sealants can result for different application fields. The applications of these new silicone sealants can be diverse. The aim of the present project has been to obtain silicone sealants curable by UV radiation for the construction field (windows manufacturing,...). The industrial validation shows that these silicon sealants can be used in a window application with simple barrier and even in a window application with double barrier, but other applications could be studied. This new silicones offer a wide range of advantages: - Short drying cycles, which allow to manipulate the pieces after a short period of time without any problem - A single component systems, without any volatile solvent content.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'WASCON 2000 Science and Engineering of Recycling for Environmental Protection' to be submitted under Fifth Framework.

assistant: **Abstract**

WASCON 2000 is the 4th in a tri-annual series of International Conferences on the Science and Engineering of Recycling for Environmental Protection. A major role for scientists, engineers and young researchers in the new century will be the conservation of energy and the preservation of a sound and clean environment.WASCON will seek to promote this objectives by:1) The presentation of papers and provision of workshops;2) Providing the opportunity for young researchers to attend the Conference by waiving the Conference, travel and accommodation costs, subject to EC funding. WASCON will bring together international experts and young researchers to present and discuss the most advanced methods available to avoid, or at least reduce, the possibilities of contamination and hazards, which could diminish the quality of the environment.Conference topics are:a) Engineering of Waste Utilisation - Novel or improved methods of waste utilisation;b) Practice of Prime Materials Replacement - The use of secondary waste materials to produce engineering composites of equal value to those made from prime materials;c) Control of Land Contamination - The control of pollution of land and water by reducing leaching, improving encasement and for cleaning contaminated land;d) Modelling for long Term Environmental Impact Predictions - Dissemination of information and research on the use of goechemical and transport models to predict long term environmental impact;e) Quality Assurance and Quality Control: Waste Product Re-use -Dissemination of information and research on QC;f) Role of Legislation -Examination of energy legislation and its impact on the technology of waste utilisation. Impact of future practice and developments will be considered, corporate response to legislative control and chan