RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Precisely Patterned Nanofibers for High Performance Bioseparations' (PURE).

assistant: **Concept**

Biopharmaceutical drugs save lives and drastically improve well-being. The number of new bio-drugs approved or in pipeline is rising but only 1/4 of patients have access to them. Bioseparation is a critical step in biopharmaceuticals manufacture. Bioseparation processes have low productivity, and are responsible for the environmental footprint and high cost of manufacturing. They use polymeric adsorbents decorated with affinity ligands that increase the selective capture of the required bio-drug. Current adsorbents originate slow processes with low capacity due to diffusive transport and the uncontrolled heterogeneous distribution of affinity ligands. Only a radical change in purification technologies can reduce the environmental footprint of biopharma industry, and increase productivity, making biopharmaceuticals quickly accessible to all.PURE envisions the pioneering of precisely functionalised purification nanofibers using principles of scalable biotechnological processes. For the first time, affinity ligands are introduced into convective adsorbents in a site-directed oriented manner and predefined spatial arrangement. Scientific and engineering principles on living organisms are combined to produce the biobased adsorbents of the future, putting Europe in the forefront of sustainable and patient-oriented biopharma. PURE brings together leading scientists and a SME as a highly interdisciplinary team with expertise in biology, chemistry, computational modelling, materials science, bioprocess engineering and applied social sciences. The new scientific knowledge and technological paradigm established in PURE have a wide window of opportunities. The scalable bioproduction of fibers with uniform ligand functionalization at predicted sites has never been achieved, and is c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accurate Real-time Tracking in LHC Full Events' (ARTLHCFE) under Seventh Framework.

assistant: **Objectives**

The goal of my project is Fast Tracker (FTK), a proposed upgrade to the current ATLAS trigger. Atlas is an experiment located at the CERN’s Large Hadron Collider (LHC), for proton 14-TeV collision studies. As the LHC luminosity will ramp up to the design level of 10^(34) cm^(-2) s^(-1) and beyond, the high rates, multiplicities, and particle energies in the detectors will pose a unique challenge. Only a tiny fraction of the produced collisions can be stored on tape and immense real-time data reduction is needed. An effective trigger system must maintain high trigger efficiencies for the interesting physics, and at the same time suppress the enormous QCD background. This requires massive computing power to minimize the online execution time of complex algorithms. A multi-level trigger is an effective solution for an otherwise impossible problem. FTK will operate at full low trigger level output rates (100 kHz) and provide high quality tracks reconstructed over the entire detector by the start of processing of the high level trigger filters. The FTK processor uses FPGA and ASIC chips to implement real-time complex track reconstruction algorithms. The 3D track's trajectories are reconstructed with almost offline quality. The system design is optimized for high-Pt trigger objects: b-jets, tau-jets, and isolated leptons. It is particularly important for the 3rd-generation fermions (b and tau) selection increasing the ATLAS discovery capability (even more at the higher instantaneous luminosity of the LHC upgrade, Super LHC). The goal of my fellow is to build and test an FTK prototype to be parasitically integrated in the ATLAS data acquisition system (TDAQ), learning the important hardware features of both Atlas TDAQ and FTK processor. At the same time I will analyze the firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Constraining the controls on the incongruent release of hafnium: implications for long-term chemical weathering rates and long-term CO2', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

An understanding of the controls on incongruent release of hafnium (Hf) during chemical weathering provides the key for the interpretation of past Hf seawater isotopic compositions, which are recorded in authigenic marine sediments. These records, in turn, integrate the weathering signal from the continents, containing valuable information about rates of chemical weathering in the past, with links to atmospheric CO2 drawdown and long-term climate change. To date, three different hypotheses have been proposed to explain the incongruent weathering of Hf. Traditionally, it has been related to the resistance of zircons to weathering. Their retention of unradiogenic Hf, however, has been suggested to be reduced during times of intense physical weathering, indicating that Hf isotopes allow the reconstruction of the intensity of physical weathering in the past. Recently, it was suggested that the preferential release of radiogenic Hf by high lutetium/Hf silicate accessory phases controls the incongruency of Hf weathering. This implies fast temporal evolution of the released Hf isotopic compositions with soil age as these phases are easily weathered and become depleted. Lastly, there is evidence that carbonate weathering is also significant for the oceanic Hf budget. The Hf isotopic evolution of seawater in the past could thus reflect the changes in the relative weathering contributions of unradiogenic silicates and radiogenic carbonates. The research seeks to obtain a detailed understanding of the processes that control the release of Hf isotopes from the continents by studying soil chronosequences and stream waters that drain variable lithologies under variable climatic conditions. The new observations will allow a more robust interpretation of seawater Hf isotope records, so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Harmonic Analysis on Real Hypersurfaces in Complex Space' under Horizon 2020.

assistant: **Concept**

This fellowship will enable the Experienced Researcher Dr. Gian Maria Dall'Ara and Dr. Alessio Martini, as Host Researcher based at the University of Birmingham, to carry out innovative research at the interface of harmonic and complex analysis. This very active research area has deep connections with the most disparate fields, from algebraic, complex and subriemannian geometry to analysis on Lie groups and numerical harmonic analysis. Despite the spectacular developments of the last decades, many fundamental problems remain open and several phenomena lack a conceptual explanation. Dall'Ara will bring a point of view influenced by mathematical physics in which some of the key questions are interpreted in terms of uncertainty principles for generalized Schrödinger operators, and he has already proved the effectiveness of this approach in a number of situations. Dr. Alessio Martini's mastery of harmonic analysis in various non-Euclidean settings will provide the crucial ingredient to disclose the full potential of these novel ideas.  The project consists of various interconnected working packages, mainly focusing on two mathematical objects naturally attached to real hypersurfaces embedded in complex manifolds: Cauchy-Szegö projections and spectral multipliers of Kohn Laplacians. The former are higher dimensional incarnations of the classical Cauchy integral, and as such they are of central importance in modern complex analysis in several variables. The project will increase our understanding of the nature of their singularities and mapping properties under general geometric assumptions involving for example the Ricci curvature. Kohn Laplacians are the natural Laplacians in this context and the study of their spectral multipliers fits into a wider set of problems lying at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dynamics of human genome architecture in stable and transient gene expression changes' to be submitted under Seventh Framework.

assistant: **Abstract**

The classical view of genomes as linear sequences has been replaced by a vision of nuclear organization that is both dynamic and complex, with chromosomes and genes non-randomly positioned in the nucleus. Process compartmentalization and spatial location of genes modulate the transcriptional output of the genomes. However, how the interplay between genome structure and gene regulation is established and maintained is still unclear. The aim of this project is to explore whether the genome 3D structure acts as an information source for modulating transcription in response to external stimuli. With a genuine interdisciplinary team effort, we will study the conformation of the genome at various integrated levels, from the nucleosome fiber to the distribution of chromosomes territories in the nuclear space. We will generate high-resolution 3D models of the spatial organization of the genomes of distinct eukaryotic cell types in interphase to identify differences in the chromatin landscape. We will follow the time course of structural changes in response to cues that affect gene expression either permanently or transiently. We will analyze the changes in genome structure during the stable trans-differentiation of immortalized B cells to macrophages and during the transient hormonal responses of differentiated cells. We plan to establish novel functional strategies, based on targeted and high-throughput reporter assays, to assess the relevance of the spatial environment on gene regulation. Using sophisticated modeling and computational approaches, we will combine high-resolution data from chromosome interactions, super-resolution images and omics information. Our long-term plan is to implement a 3D browser for the comprehensive mapping of chromatin properties and genomic featu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Efficient Organic Photovoltaic Sensors'.

assistant: **Concept**

The project Efficient Organic Photovoltaic Sensors (EFFECTOR) will deliver innovative and environmentally-friendly solutions for digital and wearable electronics at TRL7. These objects will be individually powered by harvesting low-level light and will be made from sustainable materials for a bright digital future. EFFECTOR will contribute to a strategic position through an open economy in the key digital, and human-centric emerging technology by developing highly sustainable energy harvesting under diffuse, low-light conditions in the key areas of security and health.EFFECTOR will create new sustainable European value chains for photovoltaic technologies and open new innovative business-to-business operations by doubling the efficiency of non-toxic organic solar cells for use under low-level light. It will couple in a streamline way with non-toxic, sustainable supercapacitors with advanced low power electronics. The EFFECTOR strategy is to bring solar cell technology to mainstream use by eliminating the need for mains electricity from everyday human-centred electronics. It will develop sustainable materials and processes, using non-toxic materials and reducing environmental impact applicable for a huge raft of human-centred technologies and innovations.  EFFECTOR draws on the world-leading inkjet OPV manufacturing of Dracula Technologies, the sustainable non-toxic aqueous supercapacitors of Innocell, and the high fidelity power management systems from e-peas. With its world-leading academic partners in solar cell design (SDU), high throughput industrial electronic printing and integration (VTT) and polymers for solar cell stabilization (CNRS), it will demonstrate this innovative multi-faceted approach in vital health monitoring with Polar and portable device applicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Relative Role of Reproductive Isolating Barriers During Speciation' (IsoBar) targeting Horizon 2020.

assistant: **Abstract**

Understanding the appearance of reproductive isolation is essential for understanding mechanisms underlying the origin of species. This project aims at understanding the relative importance of different isolating barriers during adaptive speciation by looking at patterns of genomic divergence. I will use numerical modelling, analysis of RNAseq data from several biotypes (incipient species) of a model organism (pea aphid), and will perform mating experiments to address four research questions:(1) Which patterns of genomic divergence arise when different isolation barriers apply? (2) Which patterns of genomic divergence do pea aphids show? (3) Do pea aphids biotypes have behavioural mate choice?(4) Which reproductive barriers are needed for the completion of speciation in hybridizing biotypes?Successful implementation of this project will improve my career perspectives, because it's training objectives were chosen to guarantee addressing skills gaps, diversifying experience and strengthening existing skills. European Research and Society will also benefit from results of this project, both though academic and economic pathways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an accurate, early diagnostic tool for ovarian cancer' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Every year, ovarian cancer (OC) kills more than 40 000 women in Europe and 150 000 worldwide. In large part this is due to the fact that most women are not diagnosed until advanced stages. There is an urgent unmet clinical need for screening tools for the early, accurate identification of OC. OC is associated with alterations in glycosylation of secreted glycoproteins, and as such, they can serve as early OC biomarkers. However, this knowledge has still not been translated into clinic due to the lack of assays that can differentiate subtle differences between glycan chains. For the first time, under the ERC consolidator grant-GLYCOSURF, we developed a synthetic glycan recognition platform that can sharply discriminate between different overall glycan structures (Patent No: WO2015/118294). Capitalizing on the knowledge of glycosylation variations in OC and our unique glycan recognition technology, we will be developing and clinically validating a new glycan-based test for detecting OC earlier and more effectively through a simple serum test. OC-associated glycans will be molecularly casted on fluorescent nanoparticles to create surface nanopockets with glycan receptors in a specific spatial arrangement to fit only OC-associated glycans. A microplate immunoassay with high sensitivity, selectivity and reproducibility will be developed, wherein the glycan-casted nanoparticles will provide a means for selectivity, signal amplification and fluorescent readout. Serum samples from OC patients and controls from women with benign tumours will be tested. The assay will be minimally-invasive, cost-effective and will be suitable for rapid, easily automatable, high-throughput screening, promoting swift translation into the clinical setting. This project offers therefore the potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Planetary Systems from Interstellar Ingredients' (PSII).

assistant: **Innovation**

Every year, more and more different types of complex organic molecules are discovered in infant star-forming regions. In my series of works, I demonstrated that the molecules found towards Sun-like protostars are qualitatively related to those found in comets in our Solar System. The outstanding challenge is that we do not know if these molecules have been inherited, or destroyed and reformed. However, the journey of material from prestellar cores and protostars to protoplanetary disks and planetary building blocks is of key importance for our understanding of the composition of (exo)planets and their atmospheres, and the origin of life.In my ERC project, I aim to quantify to what extent the chemical complexity of planet-forming material is preset in the natal environment of a planetary system. I plan on quantitatively comparing the complete (gas and ice) complex organic natal inventory to that in planet-forming material, based on cohesive unprecedented observational campaigns. I will combine radio (ALMA and single-dish) observations of gases in prestellar cores and protostars with infrared (JWST) data on ices in the same regions to obtain these complete natal inventories. I will quantify the composition of planet-forming material through the only two possible ways: direct studies of disk ices with JWST and remote sensing of comets. Thereafter, I aim to robustly understand the differences in terms of precise physicochemical processes at hand. To achieve that, I will develop a state-of-the-art physicochemical model including evolution of a core into a protostar and a disk, and a novel chemical network with complex organic chemistry and multi-isotopolog fractionation.My project ΨI will make a major contribution to our understanding of complex organic chemistry under inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Micro-arrays for the detection of the abundance and distribution of pathogenic protozoa, flagellated algae and diatoms' under Fifth Framework.

assistant: **Concept**

The environment is experiencing rapid and accelerating changes, largely originating from human activity, whether coming from local impacts or from the more dispersed effect of global climate change. Only now are we developing the molecular tools required to adequately document microbial diversity on a routine basis. These tools are arising from the combination of three powerful techniques, namely analytical flow cytometry, artificial neural nets and molecular probes. The latter coupled with micro-array construction provide a novel technique to quantify the abundance and distribution of microorganisms in a rapid and sensitive method. Phylogenetic micro-arrays will be developed to assess water quality, to monitor biodiversity of organisms difficult to identify by traditional means and to compare with traditional means of assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultra-small analytical techniques applied to single cell neurochemistry' under Sixth Framework.

assistant: **Concept**

It is proposed to develop and apply ultra-small volume analytical chemistry techniques to measure molecules important in single cell neurochemistry and neurobiology. The importance of this work to the scientific community lies in that it defines the limits for measurements in small biological environments and it provides a means to examine molecular mechanisms of neuronal function and dysfunction (ilness). Techniques using microelectrode electrochemistry will be used to measure release of transmitters from single cells. Separations with micrometer and nanometer inner diameter capillary electrophoresis will be used to measure neurochemicals in spatially localized regions of cells and organelles. Mass spectrometry imaging with submicrometer resolution will be developed to measure and determine the function of lipid domains in cell membranes. It is my goal to unify these techniques and measurements to provide a comprehensive view of the location, function and importance of membrane lipids regulating communicatio n via exocytosis. In addition, we will relate this function to the role of exocytosis proteins in regulating the exocytosis event. This project will involve new developments in each technique area and applied analytical chemistry for bioanalytical measurem ents in neurochemistry.