RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MIDDLE EAST AND NORTH AFRICA REGIONAL ARCHITECTURE: MAPPING GEOPOLITICAL SHIFTS, REGIONAL ORDER AND DOMESTIC TRANSFORMATIONS' under Horizon 2020.

assistant: **Concept**

The ‘Middle East and North Africa Regional Architecture: mapping geopolitical shifts, regional order and domestic transformations’ -the MENARA Project- will study the geopolitical order in the making in the South and East Mediterranean Countries and the Middle East amid all deep-reaching social and political changes unfolding since 2010. The project aims at describing the main features of the regional geopolitical order, its origins, and evolution; identifying and mapping the decisive domestic, regional and global actors, dynamics and trends; building future scenarios for 2025 and 2040; and informing EU policies and strategies. It will examine whether, where and when conflict and/or cohesion dynamics prevail, the level and depth of regional fragmentation and the effects of regional and domestic processes on global dynamics and vice versa. This will be achieved by analysing ideational and material factors (national, sub and supra-national identities; religion and politics; global identities; demography; energy; economy; military; environment) and by conducting in-depth research on specific case studies on ongoing dynamics at three different levels (domestic, regional and global). All this research will be based on quantitative and qualitative methods -including fact finding missions on the ground, interviews, focus groups, Delphi surveys - and innovative foresight techniques.  Research will be accompanied by pioneering dissemination methods willing to increase the project’s impact not only over the specific academic community and policy-making circles but also over broader general public. This will include the translation of research results into accessible deliverables such as audio-visuals, futures notes series, infographics and interactive maps, and a Massive Open Onl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Green REcyclable Tanks made of innovative resin rilene' (GRETA).

assistant: **Concept**

The proposed innovation is a multi-layer tank in polyethylene with low environmental impact and produced with RILENE, a special resin coming out from the reuse of plastic waste. The tank can be fully recycled at the end of its life cycle. The technology used to produce the tank is the blowing in co-extrusion which allows obtaining multi-layer materials with specific technical features that cannot be obtained with the technology commonly used for the single-layer. The main innovation consists on the material that composes the tank: RILENE, a resin derived from an accurate selection of plastic waste, from an innovative transformation system and from an original and patented recipe.The innovation will help increase the quantity of plastic waste recycled and re-introduced in the economy. In particular, it willcontribute to the reduction of CO2 emissions thanks to less quantity of plastic waste treated; fewer emissions on theatmosphere will reduce also risks to health and contribute to enhancing the well-being of society.The introduction in the market of the tank will also address the business opportunity connected to the green marketing,contributing to increasing the turnover of the green industry, creating new jobs and increasing the market share ofenvironmental products. The final users of the innovation will be the green companies that produce building materials (glues, mortars, etc), paints and colours, detergents and hydrocarbons. These users have two primary needs: a) to increase the utilization of green and ecofriendly products, b) to reduce disposal costs. The innovation can help in solving these needs thanks to its green characterization and to the possibility of being recycled and re-used several times.One of the main benefits of the innovation is the competitive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sarcoma Analysis through Neck Development' (SAND) targeting Horizon Europe.

assistant: **Abstract**

Head and neck sarcomas constitute rare malignant tumors of mesenchymal origin with poor prognosis. Rarity induces major challenges for diagnosis and limits the understanding of the molecular pathogenesis of sarcoma and its malignancy processes. Recent studies have demonstrated that tumor subsets share transcriptomic similarities with their corresponding cell lineage embryonic origins and mimic the tissue-specific developmental programs. We will combine developmental and cancer biology approaches and state-of-the-art cell transcriptomic tools to comprehensively analyze neck musculoskeletal morphogenesis and identify regulators of mesenchymal malignancy. Using the similarities between tumor and normal embryonic development, both characterized by rapid cell expansion, we will investigate embryonic pathways that could be re-initiated during tumor formation and expansion. TGFβ signaling appears critical for both tumorigenesis and neck musculoskeletal formation by modulating genetic networks involved in cell proliferation and differentiation. Manipulation of our candidate genes in sarcoma cell lines and mouse embryo will characterize TGFβ function during morphogenesis and sarcomagenesis and assess how TGFβ pathway dysregulation is associated with disease progression and treatment responsiveness. Transcriptomic sequencing at single cell level of the heterogenous neck connective tissue precursors will generate the first single-cell atlas of the developing neck. Comparison of developmental dataset with published single-cell sequencing dataset from sarcoma primary tumors and surrounding healthy tissues will allow us to identify molecular processes of normal and tumor development to uncover developmental programs associated with sarcoma induction. The collected data will allow a b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sanative Patches for Advanced Regenerative Engineering of the Heart'.

assistant: **Innovation**

Cardiovascular diseases are the leading cause of death in the world. Because the human heart has effectively no regenerative capabilities, the damage caused by cardiovascular diseases and heart attacks is both cumulative and progressive. The aim of this project is the development of regenerative tissue-engineered cardiac patches, which will revolutionize healthcare by providing patients with a treatment that seeks not to manage their symptoms, but to correct and reverse the underlying damage to the cardiac muscle. While the theory underpinning regenerative cardiac patches is not novel, reaching TRL5/6 by demonstrating proof-of-concept with 3D-printed, thick, fully vascularized, clinically relevant patches would constitute an extraordinary step forward for the field.In this project, we propose to 3D-print thick, vascularized cardiac tissues comprised of functional cardiomyocytes and blood vessel–forming endothelial cells derived from human induced pluripotent stem cells (iPSCs). The tissues will be between ½ -1 cm thick and will require significant levels of vascularization. Following fabrication, tissues will be matured in custom-designed bioreactors and reinforced, rendering them strong enough to be easily handled by surgeons. We then propose to perform cardiac-regenerative surgery in a large mammal model (pigs). This study will serve as a proof-of-concept that will advance the technology from an academic setting to the biotech industry and ultimately into the clinic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Illuminating the darkness with precision maps of neutral hydrogen across cosmic time' under Horizon 2020.

assistant: **Concept**

My proposal is to map out the 3D structure of the Universe over an unprecedentedly broad swath of cosmic time, covering 13 billion years of cosmic history. I will do this by using radio telescopes to detect the 21cm emission from neutral hydrogen. The detailed statistical properties of the maps will allow us to answer some of the most pressing questions in cosmology, such as how fast space is expanding, what the physical properties of dark energy are, and how the first stars and galaxies lit up the Universe.All experiments currently trying to make these observations are severely limited by systematic effects, exacerbated by the extremely high dynamic range between the cosmological signal and many other sources of radio emission. Even tiny calibration errors can cause huge artefacts in the data that make it extremely difficult to pick out the target signal. While a great deal of work has gone into designing methods to analyse the data, they are not yet accurate enough  by a factor of 100 by some measures.I will develop a statistical analysis framework called Total Calibration that can deliver the remaining two orders of magnitude of improvement, and apply it to the most sensitive data available. The result will be precise, systematics-free maps and the most robust statistical measurements of large-scale structure ever made in the radio. Total Calibration seeks to model all of the relevant degrees of freedom in the data simultaneously, in one large global model of the signal, contaminants, and the calibration of the telescope. This is highly complex, and has never been done before.By applying total calibration to sensitive but complex data from two cutting-edge telescopes, HERA and MeerKAT, I will obtain the most robust constraints on the 21cm signal to date, from redshif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Thermal Metamaterials' in the context of a Horizon Europe call.

assistant: **Objectives**

The main goal of this proposal, to propose self-adaptive thermal regulation systems that are smart, green, aesthetically pleasing and engineering applicable, is in line with the RePowerEU plan that efforts in saving energy and decarbonising heat. In this project, new thermal metamaterials are designed that integrates smart radiative cooling, high solar reflectance and customized colour, a multi-function design not previously available. Utilizing the metal-insulator transition of phase changing materials, the thermal metamaterial adapts its thermal emissivity smartly to different ambient temperatures, thus intelligently switching between “on cooling” mode in hot times and “off cooling” mode in cold times, which benefits creating comfortable household conditions and contributing to energy saving from an all-season perspective. Besdies, the thermal metamaterial can present vivid colours to satisfy aesthetic needs. Considering that thermally induced deformation can lead to structural failure of designed thermal metamaterials and affect their working life, mechanical robustness is also considered for scalable production and for real-world applications. A new inverse method is developed to accurately predict the structural deformation by eigenstrain reconstruction. On basis of this, mechanical stability strategy is proposed to eliminate the deformation, which pushes the smart regulation system closer to real-world application.The proposed design is estimated to save at least 134 €/year for a single family in Besançon, Franche-Comté, France. The resulted energy savings not only bring economic benefits but also contribute to environmental preservation and climate change suppression by reducing greenhouse gas emissions. This project can create significant impact in household ene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rethinking Failed Empathy in Narrative Fiction' to be submitted under Horizon Europe.

assistant: **Abstract**

This project challenges the assumption that narrative fiction is valuable because it creates understanding of other people’s experiences and lived realities through empathy. Instead, the project addresses the main hypothesis that failed empathy is a strategically created effect of narrative fiction that activates affective, emotional, and cognitive processes by foregrounding differences between fictional characters and recipients. To date, popular perception frames failures of empathy also as failures of narrative fiction to engage recipients affectively, emotionally, and cognitively. In contrast, this project reframes failed empathy as an invitation to reflect on personal, cultural, and political beliefs, attitudes, and values. The innovation of REFEMP is twofold. First, the project develops a novel methodological approach for studying its multimodal dataset. This dataset consists of 1) a transmedia sample of narrative fiction in literature, graphic novels, films, television shows, and videogames released after the turn of the twenty-first century, and 2) a selected corpus of written online reviews of the primary texts as a shorthand for recipients’ responses to and empathic engagement with characters in narrative fiction. Second, the project is theoretically innovative by making the concept of failed empathy productive as an analytical framework for narrative fiction. The project's objectives are 1) providing a more refined vocabulary for talking about medium-specific possibilities of representation and narration that can facilitate, hinder, or block recipients’ empathic engagement with narrative fiction, and 2) theorizing the cultural effects of failed empathic engagement with narrative fiction based on recipients’ reviews. To this end, REFEMP highlights the value of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting infertility associated to defective Insulin/IGF-1 signalling' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Geometry of non-Abelian effective brane theories'.

assistant: **Concept**

The proposed research is to apply recent ideas from mathematics and theoretical physics in a superspace setting. These ideas concern the differential geometry one encounters when dealing with extended objects rather than points. This should shed light on the long outstanding problem of the effective action of coincident branes, i.e. generalisations of Yang-Mills theories.The use of superspace in this novel mathematical setting seems essential to achieve this. This is a completely new approach to the problem, which will have wide-reaching consequences for the very fundaments of string theory, but also for phenomenological research in cosmology and high-energy physics model building.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European vaccine and microbicides enterprise' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The successful development of preventative strategies against HIV-1 (microbicides, vaccines or their combined effects) would provide a pivotal turning point in global efforts to combat the pandemic spread of AIDS providing an incalculable impact on solving societal problems associated with this disease. The principal aim of this proposal is to bring together EU scientists from both microbicide and vaccine fields to embrace a coordinated approach to HIV-1 prevention research. Partners in the EUROPRISE consortium represent 14 projects funded by the European Commission in the sixth Framework as well as one project funded by the Gates Foundation. These projects involve 132 institutions from 22 countries. In this respect, EUROPRISE is the first organisation, both in Europe and internationally to deliberately bring these groups together in a truly integrated fashion. EUROPRISE will promote an integrated program of research, coordinating a wide portfolio of activities encompassing the whole pipeline of vaccine and microbicide development from early discovery through to early clinical trials. This unique approach places the Network at the international forefront of understanding the interface between these two technologies, pursing a critical path to the development of effective HIV-1 prevention strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demand side management in district heating systems (DH DSM)' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The main objective of the project is to show that lowering the cost of district heating (DH) is possible by using demand side management (DSM). The project will show that the practical installation for DH DSM in a building is inexpensive and it is relatively easy to cut down and/or shift peak heating demand of a building. The objective in each test site is to cut down the peak heat consumption at peak times by 40 %. This is going to be achieved with exploiting the thermal mass of the building and its heating system by con-trolling the system properly. The project will also calculate the effects of large-scale use of DSM in many key buildings of the tested district heating systems. The project creates ways of sharing the benefit resulting from the use of DSM equally between the DH company and the end-customers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Genetic mechanisms involving ultraviolet light in the development of cutaneous malignant melanoma' (MAUVE).

assistant: **Concept**

Cutaneous malignant melanoma (CMM) is one of the most feared of all cancers because of the high degree of malignancy it displays at a very early stage. CMM has been increasing in incidence faster than any other cancer, possibly because of increasing recreational exposure to sunlight. However, proof of a firm mechanistic link to specific types of sunlight-induced DNA damage is needed before preventative advice can be given to the public with confidence. In this project, we will identify and isolate genes damaged in the various stages of melanoma genesis and use these, together with know cancer-related genes, as molecular reporters to establish the precise roles of various spectral components of UV in CMM development. This work will be complemented by directly demonstrating induction of CMM events by UV and heat (sunburn) in rodent (in vivo) and human cell culture (in vitro) model systems.