RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structural biology of Legionella’s effectors and secretion system' to be submitted under Seventh Framework.

assistant: **Abstract**

Legionella pneumophila is the causative agent of a severe form of pneumonia known as Legionnaires’ disease. Legionella utilizes a type IV secretion system, encoded by the dot/icm gene cluster, to secrete circa 300 effectors that highjack host cellular function to allow the bacterium to live intracellularly inside macrophages. Although the molecular basis of effector function has been elucidated for a small number of effectors, there remain a large number of effectors for which no function has been ascribed. Moreover, when function is known, the host target to which the effector binds has not always been identified. Finally, when effector function and target are known, the molecular basis of effector-target interaction often remains to be determined. This proposal aims to address these issues using a structural biology approach. Another issue addressed by this proposal is the structural and molecular characterisation of the Dot/Icm type IV secretion system responsible for effector secretion through the double membrane of Legionella. Therefore, we propose here three complementary lines of research: i- using a structural biology approach, we will determine the structures of functionally-uncharacterised Legionella effectors in order to derive their function; any function derived from structure will be validated by Professor Craig Roy, a leading researcher in the field of Legionella infection. ii- when/once the effector’s target is known, we will investigate the molecular basis of effector-target interaction by determining the structure of the binary effector-target complexes. iii- we will investigate the structure of the secretion apparatus that is responsible for secreting effectors through the Legionnella membrane. This proposal will greatly enhance our knowledge of the v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrochemical fluorination under microflow conditions' in the context of a Horizon Europe call.

assistant: **Objectives**

Despite the prevalence of fluorination reactions of organic compounds in the pharmaceutical industry, these reactions still encounter several problems such as low selectivity, yield, high demand on safety operational process and low sustainability.  Introduction of fluorine into drug molecules increases the drug’s lipophilicity, improves its stability and pharmacokinetic properties. Thus, the fluorination chemistry is of great importance in a pharmaceutical industry. This project is focusing on fluorination and trifluoromethylation of functionalized piperidines, organic compounds with several biological and therapeutic properties. We propose a cutting-edge interdisciplinary approach to make the fluorination reactions more sustainable, safe and to increase the reaction yield, by transferring electrochemical fluorination reaction into a flow microreactor. Advantage of electrochemical reactions is that the side products are minimized as no chemical reagents are necessary. The main advantages of microreactors are excellent heat and mass transfer properties and high surface to volume ratio. The precise control of the temperature profile in the reactor and the residence time enhances process safety and leads to high reaction selectivity. An electrochemical flow microreactor will be developed and optimized for fluorination reactions of piperidines. Collaboration of organic chemist and chemical engineers is upmost importance to succeed in this interdisciplinary project connecting organic chemistry, flow technology and microreactor engineering. Proposed innovation will show a new specific application of electrochemical microreactor. This is an important step in electrification of chemical and pharmaceutical industry which leads to overall higher sustainability of the chemical pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Isotopic evidence for the impacts of fishing on marine foodweb structure' (FIMAF).

assistant: **Concept**

Overfishing is one of the critical concerns of the European Union as it seriously threats food security and well-being of EU's fishing activities. One important aspect of overfishing is the change in the composition of fish communities, - as exemplified by temporal transition from large piscivorous fishes towards smaller invertebrates and planktivorous fishes. This may alter the trophic interactions within the ecosystem. Despite the importance of trophic interactions for ecosystem functioning, this issue remains largely unexplored especially due the inability to reconstruct historical food webs. However, this technical lock can now be overcome thanks to the method recently developed by the host institution, which demonstrated that δ13C and δ15N from otolith organic matter mirror prey isotopic signature and hence can be used to reconstruct important diet characteristics. In this project, we propose to use this cutting-edge technique for tackling the challenging question of the impacts of fishing activities on fish diet and trophic level. Thanks to a unique collection of otoliths (1900-2015) from three threatened fish species of high commercial values with different life history characteristics, namely the pelagic saithe (Pollachius virens), the bentho-pelagic cod (Gadus morhua) and the demersal haddock (Melanogrammus aeglefinus), we will investigate temporal shifts in otolith signatures occurring in response to variability in fishing pressure. This multidisciplinary research program will include several steps from the laboratory work to the statistical modelling. Due to the innovation of its thematic and its state-of-art techniques, this FIMAF program will place its coordinators and the EU at the forefront of international efforts for understanding fishing activities imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Conjugated Microporous Polymer Catalysts with Well-Defined Molecular Metal Sites and Tunable Coordination Environments for Electrocatalytic Synthesis of C-N Coupling Compounds' (COMPACT-CN).

assistant: **Concept**

The electrochemical CO2 reduction reaction (CO2RR) effectively converts and fixes CO2 but currently produces a limited range of short-chain carbon-hydrogen-oxygen compounds in aqueous electrolytes. By using small molecules like nitrate as co-reactants, CO2RR can yield valuable C-N coupling products (e.g., amide, amine), expanding its applications. Although typical metal-based, single-atom, or dual-atomic-site catalysts have been reported to catalyze electrochemical C-N coupling, their inherent structural heterogeneity, arising from defect states, high-temperature pyrolysis, non-uniform support materials, and unclear active site structures/environment, limits their selectivity, energy efficiency, and utility in mechanistic studies. To progress, a well-defined system with definite coordination environments to form structurally defined active sites is crucial for advancing electrochemical C-N coupling reactions. The COMPACT-CN project aims to develop metalated conjugated microporous polymer (M-CMP) electrocatalysts with uniform molecular metal sites to explore catalytic selectivity and kinetics for C-N coupling reactions. The key objectives are: 1) to synthesize and characterize structurally engineered M-CMPs with high performance and selectivity for C-N coupling; 2) to investigate reaction mechanisms using advanced electrochemical and in situ surface-sensitive techniques; and 3) to establish the relationship between structural properties (metal site-spacing, proton relay distance, and electron push-pull effects) and C-N coupling performance. COMPACT-CN's achievements will deepen molecular-level insights into electrochemical C-N bond coupling mechanisms and structure-function relationships in catalysts, advancing CO2/NOx conversion techniques. These approaches are essentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Environmental protection, subsidiarity principle and spatial related policies' to be submitted under Fourth Framework.

assistant: **Abstract**

To identify the conditions under which the application of the subsidiarity principle can improve environmental protection in cases of spatial related policies;to test the hypothesis that better mobilisation of those concerned locally brings about a more careful and informed management of local environmental problems.OBJECTIVES: To identify the conditions under which the application of the subsidiarity principle can improve environmental protection in cases of spatial related policies;to test the hypothesis that better mobilisation of those concerned locally brings about a more careful and informed management of local environmental problems. DESCRIPTION: The project analyses the implementation of subsidiarity through two case studies in each of the four countries (France, Italy, Spain, Switzerland) under examination. In each country, two contrasting cases are selected: a case concerning the building of a transport infrastructure, i.e. where a spatial related policy causes important environmental pressure locally, but diffuse economic benefit for the whole community; and a case of wetland site protection i.e. where environmental protection policy induces some important economic and property constraints at the local level, but an environmental advantage for the whole community. Each of the eight case studies is conducted through an analysis of the decision making process, comprising three phases: the reconstruction of the chronology, an analysis of the actors involved and the interpretation of the results. International comparisons are developed to identify similarities and variations between the conditions of implementation of similar policies in different contexts of decentralisation. In this regard the countries selected represent a wide range of institutional settings:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Electron as a Catalyst' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Is the electron a catalyst in synthesis? This fundamental question will be addressed within the frame of the suggested ERC-project. Brönsted acid catalysis is well established in organic synthesis. The electron, as compared to the proton about 1800 times smaller and omnipresent, is currently not recognized as a potential catalyst in synthesis. The concept of using the electron as a catalyst is nearly unexplored. In the suggested, challenging project this kind of catalysis and its potential in synthesis will be the target of the investigations. The aim is to establish catalysis with the electron as an independent research branch in organic synthesis. To this end, the generality and broad applicability of the concept has to be documented. Different reactions, which are currently conducted as non-chain reactions by using transition metals as redox catalysts, will be performed via electron-catalyzed radical chain processes. In view of the foreseen shortage of transition metals we consider the development of transition-metal-free chemistry as important. Guided by Mother Nature we plan to develop synthetic dehydrogenases. Unactivated aliphatic sites in complex substrates will be selectively oxidized to the corresponding alkenes. Remote regioselective C-H functionalization in complex molecules comprising C-C- and C-X-bond formation will be investigated and also transition-metal-free radical arene and alkene C-H functionalization will be explored. Furthermore, the potential of electron-catalysis in asymmetric synthesis will be elucidated. Preparative and kinetic experimental studies will be supported by theoretical chemistry, new methods for initiation of electron-catalyzed processes will be developed and also mechanistic studies will be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Aerosol technologies and hierarchical assembly/ manufacturing for advanced nano-structured porous materials', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

ATLANTIS is motivated by the fact that suitably 3-D engineered and functionalised porous structured reactors can bring important breakthroughs not only in the already established market for automotive emission control systems, but also on the emerging biotech market of protein antibodies and bio-polymers.The S&T objectives are to produce the required knowledge base and component technologies and apply them for the manufacturing of:- a highly efficient, compact, multifunctional, emission control system for removal of gaseous and particulate emissions from future Diesel engines;- a hyper-compact, high yield-continuous mode integrated bioreactor/separator for the bio-production of polymers and of high value recombinant protein antibodies.ATLANTIS radical innovations stem both from novel processes and novel products and include:- hierarchical assembly/manufacturing for new porous materials, built from 0-D (powders), 1-D (fibers), 2-D (sheets) and 3-D (foams/honeycomb monoliths) building blocks, of diverse metallic and ceramic materials;- functionalization with catalysts and biocompatible surface treatments/coatings, employing novel Aerosol Technologies for 3-D tailoring of porosity and surface characteristics.The multidisciplinary and diverse application targets of ATLANTIS pulls together advanced R&D efforts in Europe, integrating different blocks of research activity. ATLANTIS will shorten the distance between R&D and market deployment in established as well as in niche ones.The critical mass achieved within the Consortium, led by a strong industrial leadership, includes specialized research centres, complemented by four large key industry players and five high tech SMEs, to ensure that R&D activities have a clear market orientation, secured exploitation of results and co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Control of imitation and social cognition: the interaction of motor mirroring and Theory of Mind' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Recent work based on ideomotor theory and the discovery of the mirror neuron system has suggested that the observation of an action is associated with the activation of the corresponding motor representation in the observer. In accordance with this hypothesis it has been demonstrated that observing an action interferes with one’s own actions when these are different from those being observed. This, however, raises the question how we avoid automatic imitation? More specifically, how can we distinguish the motor program activated by our intention from that triggered by observation? Recent neuroimaging studies have revealed that the control of automatic imitative responses leads to activation in the anterior medial prefrontal cortex and the temporo-parietal junction. These areas are core regions of a network involved in higher-order abilities in social cognition, such as mentalizing (i.e., the ability to reflect on other people’s mental states). Based on such brain imaging results, it has been hypothesized that the control of shared representations draws on the interaction between these ""social"" brain regions and the mirror system. The proposed study aims to understand how high-level cognitive functions and motor mirroring interact at a neural level in the control of imitative behaviour and to explore the functional overlap between the control of shared representations and implicit forms of mentalizing. The research place itself at the interface between the research on motor control and social neuroscience and wants to integrate knowledge developed in different domains. With these objectives in mind, the applicant will conduct a series of studies by combining different methodological approaches and techniques, such as brain stimulation techniques and neuroimaging, and u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Study of human tsh-receptor activating mutations'.

assistant: **Concept**

Somatic and germinal mutations of the human Thyrotropin-receptor have been found in cases of thyroid toxic adenomas and thyroid toxic hyperplasia respectively, more frequently than was expected, and in different regions of the receptor. Functional characterization of these mutations shows that they lead to a constitutive activation of the TSH-receptor producing thyroid cell proliferation and hyperfunction. Wild- type receptor also apparently displays some constitutive activity in contrast to other G-protein coupled receptors. New mutations will be searched and more precisely characterized for ligand affinity, and coupling efficiency through transfection experiments. Equivalent mutations will be produced in related receptors (LH and FSH receptors) and chimeric receptors to study the functional importance of the mutated residues in terms of constitutive activity and signal transduction. Mapping of functional regions should be obtained with a better knowledge of transduction mechanisms through G-protein coupled receptors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High temperature thermal energy storage in saturated sans layers with vertical heat exchangers ('TESSAS')' (TESSAS).

assistant: **Innovation**

When energy supply and demand is not balanced, storage is necessary. The duration of storage is a parameter of prime importance for energy stores. Short-term thermal energy storage (a few hours to several days) is a common technique but only long-term storage will save energy. Different mediums can be used such as soil and water bearing layers (Underground Thermal Energy Storage-UTES). Goal of the project is the demonstration on a real scale (600 mwh of store) of thermal energy storage in the underground at a temperature between 40°C and maximum 85°C with VHEs (Vertical Heat Exchangers) placed into soil, composed of water-saturated sand layers. The project store will be exploited under realistic conditions (stand -alone situation).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Differential role of atypical Rho GTPases Miro-1 and Miro-2 for controlling mitochondrial dynamics and transport'.

assistant: **Concept**

Regulated transport of mitochondria is essential for providing ATP spatio-temporaly to power nerve cell function and calcium buffering during release of neurotransmitters or post-synaptic receptor activation. The major player of this transport machinery is Mitochondrial Rho GTPases Miro-1 and Miro-2 present at the mitochondrial outer membrane which controls binding to the Kinesin for transport along microtubules. Miro-1 and 2 are paralogs shares ~60% homology in mammals (while  nematode Caenorhabditis elegans and plants have 3 paralogs) while others have only one copy of Miro proteins. Using high resolution 3D live cell imaging, co-immunoprecipitation followed by mass spectrometric identification, expression of genetically encoded sensors in combination with pharmacological, electrical and optogenetic stimulation of neuronal activity in vivo, the molecular mechanism that allow two Miro proteins to tailor the spatial distribution and morphology of mitochondria will be explored. A key goal will be to explore the differential role of the Miro-1 and Miro-2 which can regulate diverse cellular processes such as constitutive and activity-dependent mitochondrial transport, ER-Mitochondria contact and calcium signalling in cultured cells and dendritic shafts and synapses in vivo. I will also try to identify novel proteins that interact with Miro-1 and Miro-2 proteins and their role in maintaining mitochondrial morphology and transport. To extend this knowledge further the role of Miro proteins in axonal transport and calcium signalling in vivo will be investigated with a deletion model in C. elegans. These studies will significantly advance our current understanding of the role played by mitochondrial trafficking for controlling diverse cellular function and may also help unders