RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extracellular vesicles’ transcriptomics: unravelling the role of short non-coding RNAs in autoimmunity' in the context of a Horizon 2020 call.

assistant: **Objectives**

It is estimated that over 36 million Europeans suffer from an autoimmune disease (AID) and according to the EuropeanLeague against Rheumatism one third of people of all ages are affected at some point during their lifetime. AIDs are asignificant clinical problem, however, most of the current therapies target the terminal phase of inflammation and do notsuppress the fundamental events responsible for the initiation of the autoimmune process. The EXAUTOIMMUNE projectwill use Sjögren’s syndrome (SS), one of the most common AIDs, as a model to create innovating strategies for dissectingthe fundamental processes involved in the initiation of the autoimmune response. By using state-of-the-art nanotechnologywe will characterize the extracellular vesicles (EV) secreted by the salivary gland epithelial cells, the main target ofautoimmune responses in SS, and test their immunoregulatory properties. Then, we will apply next-generation sequencing toanalyze the EVs’ RNA content and identify candidate RNA molecules that can be functionally tested for disruption ofautoimmune processes. Linking EVs and extracellular RNA to autoimmunity is a fundamental theme of the currentknowledge. The results of the proposed research will substantially add to the delineation of the biological relevance ofextracellular RNA in modulating the regulatory mechanisms leading to autoimmunity. This study will form the foundation fortransitioning from human biology to a mouse model, where the potential therapeutic value of EV and/or RNA-targeting will betested, thus opening the best career opportunities for the applicant as a leader in this newly emerging landscape.Spearheading this research using next-generation tools and ideas will produce long-term synergies and will define EU andERA as world leaders in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Between the sacred and the mundane: A historical inquiry into travel and travelling practices on the Ottoman pilgrimage road from Üsküdar, c. 1517-1800.' (OTTOHAJJ), addressing dissemination and exploitation.

assistant: **Impact**

The hajj caravan was likely the largest and most regular flow of peoples and commodities through the arteries of the Ottoman empire. Yet surprisingly little is known about the experiences of Ottoman pilgrims who took the overland route to Mecca and Medina each year. OTTOHAJJ will investigate early modern (c. 1517-1800) Ottoman travel through an in-depth study of the material and human aspects of the caravan from skdar to Mecca. The project has four main objectives: Undertaking research in manuscript libraries in order to build a corpus of Ottoman hajj guidebooks authored by pilgrims; Classification and analysis of these sources, exploring intertextuality, authorship, and milieu of authors; Investigating the infrastructure of pilgrimage in order to produce a typology of locations, including sacred sites, facilities, and places of leisure, rest and relaxation; Constructing a typology of social profiles and associated traveling patterns of pilgrims. The use of guidebooks will be supplemented by other Ottoman Turkish and Arabic sources, including travelogues, chronicles, documents, objects, and images. The project will provide data on the diverse territories of the former Ottoman empire and traveling practices within them, a crucial undertaking since climate change and rapid urban transformations continue to irreversibly alter the landscape and diminish ecological diversity. This data will allow us to better understand the social, religious, cultural, ecological, and scientific history of the early modern empire. The project will also make important contributions to the study of manuscript cultures and the application of digital humanities in Ottoman studies. Project outputs include a monograph on traveling practices and mobility, a critical edition of a late-sixteenth-cent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Precursors to Modern Aerobic Ammonium Oxidation: Oxygenic and Electrogenic Anaerobic Pathways' to be submitted under Horizon 2020.

assistant: **Abstract**

How did microbes evolve to use O2? How did O2-dependent pathways derive from or evolve under anoxic conditions? This central evolutionary mystery remains essentially unresolved. I contend that it is possible to identify the evolutionary history of modern aerobic pathways (APs), by discovering the vestiges of ancient anaerobic pathways (AnPs) that persist in modern microbes. Aerobic nitrifiers contain aerobic metabolisms, while few clues such as chlorite dismutase enzyme in Nitrospira, NO dismutase enzyme in Methylomirabilis, and electrochemical signals from aerobic nitrifiers support the notion that remnants of AnPs remain. Hence, I postulate that in nitrifiers currently considered strict aerobes, I can identify the vestiges and integral remains of the earliest APs: I will identify the AnPs of NH4+ oxidation that are driven by intracellular O2 production and respiration mediated by EET. By applying BES and batch incubations followed by isotopic and genomic experiments will evidence and characterize the novel AnPs in nitrifiers. Single cell genomics on FAC-sorted fluorescent-tagged cells followed by molecular phylogenetic analysis will provide a major contribution to unravelling the early evolution of aerobiosis and aerobic NH4+ oxidation, which is crucial as we seek the origins of life on Earth, and other planets. PAERADOX will provide me an interdisciplinary research training in the area of microbial physiology and genomics, molecular biology and computational evolution through international mobility (Harvard, MIT and DTU). Such a training-through-research platform will enhance my career development to a large extent. My return and reintegration to DTU will provide basis to transfer my interdisciplinary combination to European scientific community. I am confident that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Discovering the signalling pathways and physiology of active rhomboid proteases in the brain' (NeuroRhomboid) targeting Horizon 2020.

assistant: **Abstract**

Proteases control major pathways in the nervous system and aberrant proteolysis underlies many neurobiological disorders and diseases e.g. Alzheimer's and Parkinson's disease. Signal generation and release is tightly regulated by protease activity, as many key signalling factors are synthesised as transmembrane precursors that require cleavage to liberate their active ectodomains. The largest family of intramembrane proteases are the newly discovered rhomboids, which are found in all kingdoms of life. To date, their physiological significance in mammals is largely unknown, as is the substrate-selectivity of most mammalian rhomboids. I have exciting preliminary data that two uncharacterised mammalian rhomboids, RHBDL1 and RHBDL3, are specifically highly expressed in primary neurons in the CNS. Unlike the well-studied RHBDL2 and Drosophila rhomboids 1-3, they do not have activity against EGF-like growth factors, so they are likely to cleave a novel substrate. A major limitation in protease research has been the lack of unbiased and systematic screens for their substrates. Addressing this deficiency, first, I aim to identify RHBDL1/3-dependent substrates in primary neurons, by adapting recently developed biochemical assays, such as SPECS and BioID. My second aim is the mechanistic validation of these substrates. Third, I will be the first to study the physiological role for active rhomboids, using CRISPR-mediated knock-out neurons and mice. By discovering the role and function of RHBDL1/3 in the brain, I will make an important contribution towards the elucidation of the physiological and medical significance of rhomboid proteases in mammals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Aftermath of a Drug Withdrawal: Modeling Spillover Effects Across Countries and Across Categories' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The pharmaceutical market is one of the most important industries in the global economy. Projections are that spending on medicines will grow to 1.2 trillion US$ in 2016. Marketing has an important impact in this pharmaceutical industry, but has a particularly negative image. The growing pharmaceutical market increases the pressure for the regulators to approve new medicines and for firms the pressure to market their drugs to stay ahead of the competition. These forces have contributed to the fact that over the past decade many drugs were approved too early, and the number of withdrawn drugs has doubled. A drug withdrawal is when a drug is taken off the market, because it is considered to be harmful typically due to unexpected adverse effects (including deaths). Since the pharmaceutical market directly concerns population health, drug withdrawals can have disastrous consequences. While there has been some research done into the aftermath of a withdrawal from the perspective of the focal drug, very little research has been done on the spillover effects. This project is the first to explicitly focus on spillover effects in the aftermath of drug withdrawals. There are two types of spillover effects to consider (i) across drugs (Do doctors start prescribing the competing drug, or has the withdrawal a negative spillover effect?), and (ii) across countries (If a country lags in withdrawing a drug, does the withdrawal in leading countries spill over?).Advanced econometric techniques will be used to model the dynamics before and after withdrawals, including spillover effects and the dynamics between sales and marketing. Results of this project will not only benefit managers of pharmaceutical firms, but is also important from an economic (i.e. given the size of pharmaceutical ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A groundbreaking no contact, roll to roll, modular transportation and fluid delivery technology that enables faster and more uniform chemical reaction of any feature size without risk of damage.'.

assistant: **Concept**

A major problem with current chemical processing tools is that they use rollers to transport and support foil (any thin roll-to-roll substrate) through chemical treatment chambers located between un-winding and re-winding mechanisms. Roller transport limits and potentially prohibits fine detail treatment and reduces yield (to 10% in extreme cases) due to damage caused by contact with such rollers. Current technology employs long process tanks and slow speeds to minimise contact damage. In applications where contact is of less concern rollers still limit capability as the force required to turn them results stretching or breaking of the foil limiting foil type, thickness, and process residence times.Fluid Foil will provide frictionless, non-contact, modular transportation and fluid delivery technologies that enable chemical processing of any feature size without risk of damage to the web. Extremely low re-wind tensions enable processing of thin delicate and porous materials. Web processing density of 30 meters of web per linier meter of system dramatically increases processing speeds and most importantly places no limit on web length. Modular control software will complete activities such as data logging and real time fault analysis.Fluid Foil will have the capacity to accelerate innovation printed, organic & flexible electronics as well as enabling potential new markets to emerge (e.g. graphene, e-textiles and paper products). This will be achieved via the provision of low cost and adaptable machinery to fabricators, opening up chemical processing to SMEs. The commercial aim of the project is to limit the time-intensive work that goes into the customisation of machines and software and reduce the lead time and cost to the customer while increasing our output.Our goal fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interaction and Symmetry Breaking of Counterpropagating Light' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Light is generally expected to travel through media independent of its direction. Exceptions can be achieved eg. through polarization changes induced by magnetic fields (known as the Faraday effect) together with polarization-sensitive birefringent materials. However, light can also be influenced by the presence of a counterpropagating light wave. We have recently shown that this leads to the surprising consequence that light sent into tiny glass rings (microresonators) can only propagate in one direction, clockwise or counterclockwise, but not in both directions simultaneously. When sending exactly the same state of light (same power and polarization) into a microresonator, nonlinear interaction induces a spontaneous symmetry breaking in the propagation of light. In this proposal we plan to investigate the fundamental physics and a variety of ground-breaking applications of this effect. In one proposed application, this effect will be used for optical nonreciprocity and the realization of optical diodes in integrated photonic circuits that do not rely on magnetic fields (an important key element in integrated photonics). In another proposed experiment we plan to use the spontaneous symmetry breaking to demonstrate microresonator-based optical gyroscopes that have the potential to beat state-of-the-art sensors in both size and sensitivity. Additional research projects include experiments with all-optical logic gates, photonic memories, and near field sensors based on counterpropagating light states. Finally, we plan to demonstrate a microresonator-based system for the generation of dual-optical frequency combs that can be used for real-time precision spectroscopy in future lab-on-a-chip applications. On the fundamental physics side, our experiments investigate the inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Feeling awake while asleep:  A neurophenomenological study of sleep state misperception in insomnia and narcolepsy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sleep is a basic need that represents a critical public health issue when disturbed or insufficient. Sleep state misperception (SSM) – the mismatch between subjective reports (what individuals perceive) and objective measures (what sleep specialists record) – complicates the diagnosis and treatment of sleep disorders. SSM is common in sleep disorders, including insomnia and narcolepsy, both of which struggle with managing the transition from wakefulness to sleep and exhibit severe overestimation of sleep onset latency. Despite recent advances in understanding the neurophysiological aspects of SSM, its subjective dimensions remain largely unexplored. This project aims to address this gap by integrating novel first-person methods from consciousness science, Micro-phenomenology and Temporal Experience Tracing, with objective neurophysiological data to better understand the experiential mechanisms behind SSM in insomnia, narcolepsy, and healthy controls. We will investigate SSM at three critical levels: 1) during the shift from wakefulness to sleep, using polysomnography and micro-phenomenology to identify the minimal requirements for feeling asleep and strategies developed by sleep disorder patients to facilitate/resist this transition; 2) during morning retrospective evaluation of sleep, using Temporal Experience Tracing to capture the dynamics of how sleep experiences are remembered and evaluated across a night of sleep, and its impact on morning fatigue; and 3) across multiple nights, to assess how day-to-day fluctuations in daytime cognition (mind-wandering, tiredness) and nighttime cognition (dreams) relates to SSM and mental health, using a 2-week protocol with actigraphy. This project has the potential to reveal key experiential dimensions related to SSM that have b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Science Advice for Policy by European Academies' (SAPEA) under Horizon Europe.

assistant: **Objectives**

The project 'Science Advice for Policy by European Academies' (SAPEA) is part of the Scientific Advice Mechanism of the European Commission. At the request of the EC, it provides targeted scientific evidence in a timely and transparent manner to inform the production of science advice by the Group of Chief Scientific Advisors while ensuring the highest scientific quality, developed by complete and independent evidence analysis and synthesis. SAPEA comprises five European Academy Networks: Academia Europaea, ALLEA, Euro-CASE, FEAM and YASAS. It contributes to widening participation by mobilising its network of some 110 academies from more than 40 countries across Europe, each with hundreds of Fellows. SAPEA aims to strengthen the links between European science academies and to ensure their active participation in its activities.SAPEA assembles interdisciplinary working groups of scientific experts. The working groups produce Evidence Review Reports or other scientific inputs for the Chief Scientific Advisors. The process is supported by Systematic Literature Reviews. SAPEA aims to ensure wide geographical coverage including Widening Countries and gender diversity, coverage of all relevant scientific fields and interdisciplinarity in the process, as well as an open and inclusive approach to involve experts who are not Academy Fellows, and early and mid-career researchers. Experts contribute on a voluntary basis.SAPEA organises an inclusive dialogue about major societal challenges via a series of events, social media and further D&E&C activities to communicate the project’s results and the work of the Group of Chief Scientific Advisors, engaging with the scientific community, policy-makers, stakeholders and the wider public. These activities contribute to increasing awaren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MODERN - MObility, Development and Energy use ReductioN' (MODERN), addressing dissemination and exploitation.

assistant: **Impact**

The project outlines a bold package of integrated measures in all the cities of the consortium, and covers all the areas required by the CIVITAS PLUS programme. The project shows ambitious goals which will have a substantial impact on the state of the mobility in the cities and a good visibility at the European level, mixing measures with large scale application actions based in existing and commercially available technologies, and measures with more advanced trials and methodologies.The project has common main targets:- To increase the quality and the effectiveness of the public transport system (from the environmental and from the service point of view), increasing the number of users;- To limit the waste of energy and to support the diffusion of the use of clean fuels among the citizens;- To support the effort of improvement of public transport through a series of measure capable of limiting the circulation of private cars;- To give value at alternative “sweet” mobility modes improving safety and liveability for their users;- To lower the number of accidents on the roads;- To increase the technological endowment of the cities as a support to more and more intelligent mobility management policies and as a service to citizens;- To diffuse as much as possible the culture of an environmental sustainable mobility among citizens and to increase the social awareness of the vital importance of these themes.The project has 49 different measures within 5 middle-size cities: Craiova (Romania - Project Coordinator), Brescia (Italy), Vitoria Gasteiz (Spain), Coimbra (Portugal), and Ostrava (Czech Republic) and 25 partners with all the Municipalities and all the local PT companies.Another crucial target is to assess a wide communication and debate among the cities at the level of