RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoding the mechanisms of centrosome duplication' under Seventh Framework.

assistant: **Concept**

Centrosome duplication entails the formation of a single procentriole next to each centriole once per cell cycle. The mechanisms governing procentriole formation are poorly understood and constitute a fundamental open question in cell biology. We will launch an innovative multidisciplinary research program to gain significant insight into these mechanisms using C. elegans and human cells. This research program is also expected to have a significant impact by contributing important novel assays to the field. Six specific aims will be pursued: 1) SAS-6 as a ZYG-1 substrate: mechanisms of procentriole formation in C. elegans.  We will test in vivo the consequence of SAS-6 phosphorylation by ZYG-1. 2) Biochemical and structural analysis of SAS-6-containing macromolecular complexes (SAMACs).  We will isolate and characterize SAMACs from C. elegans embryos and human cells, and analyze their structure using single-particle electron microscopy.  3) Novel cell-free assay for procentriole formation in human cells. We will develop such an assay and use it to test whether SAMACs can direct procentriole formation and whether candidate proteins are needed at centrioles or in the cytoplasm.  4) Mapping interactions between centriolar proteins in live human cells. We will use chemical methods developed by our collaborators to probe interactions between HsSAS-6 and centriolar proteins in a time- and space-resolved manner.  5) Functional genomic and chemical genetic screens in human cells. We will conduct high-throughput fluorescence-based screens in human cells to identify novel genes required for procentriole formation and small molecule inhibitors of this process.   6) Mechanisms underlying differential centriolar maintenance in the germline. In C. elegans, we will characterize how th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Forest fire spread prevention and mitigation' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

SPREAD provides a framework for the development and implementation of an integrated forest fire management system for Europe. It will develop an end-to-end solution with inputs from Earth observation and meteorological data, information on the human dimension of fire risk, and assimilation of these data in fire prevention and fire behaviour models. It will provide new tools for fire management, in close collaboration with regional and national forest agencies, and new approaches to post-fire landscape management. SPREAD adopts a highly interdisciplinary and innovative approach that builds on the key scientific achievements of the contributing teams over the last decade. A strong management team will be responsible for integrating research across the project, for disseminating the research outputs, and for delivering the fire management system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Appraising the Critical Role of prognostic Biomarkers in the Assessment and Triage of sick African newborns: Advancing a point-of-care device based on sTREM-1 towards CE marking and implementation', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The main concern of clinicians when addressing sick patients is to promptly identify -i.e., “not miss”- those at higher risk of severe disease, so as to prioritize their care and better target therapeutic interventions. Unfortunately, risk-stratification practices for infections remain suboptimal and prone to misclassification, leading to adverse outcomes and misallocation of resources, particularly in children (and even more so among newborns) from Sub-Saharan Africa (SSA). We recently developed “B-Triage”, a point-of-care rapid triaging test, designed for the quantitative assessment of sTREM-1, a biomarker of sepsis, and a highly performing prognostic marker, irrespective of underlying disease. Levels of sTREM-1 stand out as a quantitative and independent predictor of severity and death in all-cause infections, being superior to other markers and clinical scores, showing promise also for risk-stratification of non-communicable diseases. We propose to specifically validate B-Triage for risk-stratification of all cause sickness in the newborn, the age group concentrating ~50% of all child mortality. ACROBAT-newborns aims to continue and accelerate the valorisation of our device, with clinical studies in Mozambique, Ethiopia, Uganda and Gabon; the industrialization of its prototype; and a go-to market strategy for SSA. The project includes strong components of health economics and impact assessment, as well as socio-behavioural sciences (usability, acceptability, and feasibility studies), with the overarching aim of generating the necessary evidence to support B-Triage’s introduction to the African market. The proactive use of our device for risk-stratification of the sick newborn at first clinical presentation, will determine, objectively and with high precision, those
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High power laser cutting for heavy industry' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This project entails research with the goal to extend laser cutting of steel based metals to thickness' above 20 mm and laser powers in the 10 kW range, with adequate accuracy and economically viable cutting speeds. The technical approach will be to develop mirror based cutting heads with truly coaxially gas jet chamber and laser beam path from the final focusing mirror.The project consist of three phases:Phase 1: Fundamental studies of cutting front mechanisms, beam propagation, nozzle design and chemical reactions in te cut kerf with special emphasize on high laser powers and thick sections;Phase 2: Development of mirror based test cutting heads;Phase 3: Test and evaluation of the cutting heads on two high power CO2~1asersources in the 6-12 kW power range. The test phase will concentrate on cutting steels, applied in the heavy industry. BE97-4212
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemistry and interface tailored lead-free relaxor thin films for energy storage capacitors' (CITRES) targeting Horizon 2020.

assistant: **Abstract**

The goal of CITRES is to provide new energy storage devices with high power and energy density by developing novel multilayer ceramic capacitors (MLCCs) based on relaxor thin films (RTF). Energy storage units for energy autonomous sensor systems for the Internet of Things (IoT) must possess high power and energy density to allow quick charge/recharge and long-time energy supply. Current energy storage devices cannot meet those demands: Batteries have large capacity but long charging/discharging times due to slow chemical reactions and ion diffusion. Ceramic dielectric capacitors – being based on ionic and electronic polarisation mechanisms – can deliver and take up power quickly, but store much less energy due to low dielectric breakdown strength (DBS), high losses, and leakage currents. RTF are ideal candidates: (i) Thin film processing allows obtaining low porosity and defects, thus enhancing the DBS; (ii) slim polarisation hysteresis loops, intrinsic to relaxors, allow reducing the losses. High energy density can be achieved in RTF by maximising the polarisation and minimising the leakage currents. Both aspects are controlled by the amount, type and local distribution of chemical substituents in the RTF lattice, whereas the latter depends also on the chemistry of the electrode metal.  In CITRES, we will identify the influence of substituents on electric polarisation from atomic to macroscopic scale by combining multiscale atomistic modelling with advanced structural, chemical and electrical characterizations on several length scales both in the RTF bulk and at interfaces with various electrodes. This will allow for the first time the design of energy storage properties of RTF by chemical substitution and electrode selection.The ground-breaking nature of CITRES reside
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Zinc Air Secondary innovative nanotech based batteries for efficient energy storage' under Horizon 2020.

assistant: **Concept**

In ZAS the topic NMP-13-2014: ""Storage of energy produced by decentralised sources"" will be addressed in order to improve the performance of rechargeable zinc-air batteries as a promising option for stationary energy storage. The overall objective of ZAS is to enable the use of distributed and intermittent renewable energy sources by further developing this type of battery technology. The new battery is expected to have an energy density higher than 250 Wh/kg and 300 Wh/L, and reversibility of more than 1000 cycles at 80 % DOD, good safety performance and a cost lower than 300 €/kWh.Through close interaction between computer simulations and experimental testing, ZAS will select and develop nanostructured electrode and electrolyte materials used in an innovative cell design. Modelling materials, structures, and dynamics on different length scales will contribute to a rational cell. After generation of the materials and validation of our full cell model, we will predict cell performance for a variety of cell designs and operating conditions, providing data into the technology validation by simulating different scenarios including hybrid systems in which zinc-air batteries are used as storage devices. The synergy with other technologies will be obtained through the strong experience the members of the consortium possess towards other types of metal-air batteries and in related technologies e.g. hydrogen fuel cells and water electrolyzers. The involvement of an end user in the consortium will ensure that the developed technology meets the requirements for hybrid constellations of energy storage. The exploitation and business plan developed in ZAS will be based explicitly on energy system simulation and validation of the feasibility of using zinc-air batteries for energy s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breeding forage and grain legumes to increase EU's and China's protein self-sufficiency' (EUCLEG), addressing dissemination and exploitation.

assistant: **Impact**

EUCLEG aims to reduce Europe and China’s dependency on protein imports by developing efficient breeding strategies for the legume crops of major economic importance in human food and animal feed. The objective is to improve diversification, crop productivity, yield stability and protein quality of both forage (alfalfa and red clover) and grain (pea, faba bean and soybean) legumes. Using diverse and extensive genetic resources and taking advantage of advanced molecular tools, EUCLEG aims to identify and develop the best genetic resources, phenotyping methods and molecular tools to breed legume varieties with improved performance under biotic and abiotic stresses in the representative European and Chinese agro-ecological areas. The potential for new uses of forage species for human nutrition will be explored. Searchable databases will be developed or built to host passport, agronomic and genetic data facilitating exchanges and use of genetic resources. The evaluation of genetic resources in multi-site trials will allow to broaden the breeding material and extend agro-ecological adaptation. The genetic architecture of key breeding traits will be analysed using association studies in order to identify molecular markers related to phenotypic traits. Finally, genomic selection strategies will be assessed for their potential to improve genetic progress. Practical tools for genotyping, data management and calculation will be provided to breeders to implement marker-assisted selection and genomic selection leading to the creation of new varieties in the long-term. The partnership gathered in EUCLEG, combining public institutes and private companies of Europe and China, guaranties the transfer of knowledge from research to seed industry.


**Keywords:** protein yield, quality, yi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Time-Resolved Structural Imaging of Chemical Transition State Dynamics' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

For bonds to be broken and new bonds to be formed, chemical reactants have to come close to each other and evolve through transient intermediate configurations known as the transition state. Transition state dynamics is closely related to reaction mechanisms and of fundamental importance in chemistry. Much work has been done to unravel these dynamics, which often involve major structural rearrangement of atoms. However, there are a lot of open questions since to date none of the applied spectroscopic techniques has directly delivered the time-dependent transition state structure. I propose to develop a novel probe that images, one molecule at a time, the full three-dimensional atomic configuration of individual transition states as they evolve: Reaction precursors are prepared using molecular ions and small (ionic) clusters with defined initial structure and tunable internal temperature. Starting from these well-defined initial configurations, chemical dynamics will be initiated by a femtosecond laser pulse. Timed Coulomb Explosion Imaging, induced by extremely short intense laser or X-ray pulses together with full coincidence momentum imaging of all fragments is then applied as a probe. The latter yields the evolving transition state structure by mapping the position of all atoms as a function of time-delay between the two pulses. I argue that the progress in laser technology in recent years was imperative to make such a scheme feasible now, since it allows measurements at high repetition rate, which is absolutely crucial. I propose work packages of increasing complexity to study ground state chemical reactions in the presence of solvent molecules and under the influence of a control pulse. The structural information obtained from Coulomb Explosion Imaging gives direct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Micro-scale δ34S variation of sulfide species' to be submitted under Horizon 2020.

assistant: **Abstract**

Sedimentary sulfur (S) isotope systematics (δ34S) has been widely used in paleoredox reconstruction of early Earth’s environments. Large-scale variations in the δ34S record are typically interpreted to reflect fluctuations in the global S cycle. However, the expression of S isotope fractionation is sensitive to open- vs. closed-system conditions and heterogeneous micro-scale δ34S patterns can form in S-bearing phases that precipitate over time in evolving pore-water conditions. Such intra-sample δ34S variability is undetectable in traditional bulk analyses, which has been the conventional approach in time-series δ34S compilations. Moreover, early- and late-stage interactions between organic matter and inorganic sulfide (thermochemical sulfate reduction) can impact δ34S signatures at different stages of sulfide formation leading to sulfide species with distinct δ34S compositions. Therefore, the existing stratigraphic bulk-rock pyrite δ34S compilations possibly integrate a whole spectrum of δ34S variability that may not reflect the depositional isotope composition. MicroS project will take advantage of high-resolution in situ analytical methods (SIMS, synchrotron-based X-ray spectroscopy) to investigate the micro-scale variability in organic-rich sedimentary rocks and its applicability to key intervals of Earth’s history. The project focuses on three organic-rich sedimentary basins: ~2.0 Ga Onega, ~2.1 Ga Francevillian and the modern Guaymas Basins, that share several characteristics, such as a semi-restricted rift environment, syndepositional magmatism and hydrocarbon seepage. By examining the δ34S composition of the co-existing sulfide species (e.g., pyrite, pyrrhotite, organic sulfur) and placing them into the geologic context of the individual basins, the project aims
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Perceptual functions of Drosophila retinal movements and the underlying neuronal computations'.

assistant: **Objectives**

Sensory perception is often an active process, and many animals move their sensory organs to actively shape their interactions with the outside world. Active sensing can provide animals with important information that impacts their survival and overall fitness. We recently found that Drosophila adjust their visual input by moving their retinas underneath the stationary lenses of the compound eye. The discovery of retinal movements in the fly provides us with a fantastic toolbox to study the cellular mechanisms of active visual computation.We found several types of Drosophila retinal movements, including an optokinetic reflex that likely helps gaze stabilization. The functions of other types of retinal movements we described remain to be shown. We found tiny movements that shift the retina only by a fraction of the angle between photoreceptors, resembling so-called ‘microsaccades’ in primates. In humans, these eye movements happen during visual fixation and their functions are still not entirely clear. We want to understand how flies, which have a very different visual system, benefit from such movements. We also found large convergent, or cross-eyed, retinal movements that happen when flies cross obstacles in tethered walking. Genetic silencing of retinal motoneurons suggested a role of these movements in depth perception. We will probe the visual system during vergence movements to understand how the neural system uses dynamic input to gauge distances. The overarching goal is to unravel neuronal computations that use actively generated visual input to extract information about the world. The fly’s relatively simple nervous system, its rich visual behavior, and outstanding experimental tools will allow for detailed insights into active sensory computation on a cellular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Vibration and noise drop by light high damping structures (VINO)' in the context of a Fifth Framework call.

assistant: **Objectives**

Production time reduction is one of the main requirements for manufacturing processes today. In order to achieve this goal, machines are becoming lighter and poorly damped. Therefore, dynamic and acoustical problems have been stressed. The aim of this project is to solve that problem using glued light and highly damping structures made of cheap conventional materials. An agile integrated design environment, a methodology to get damping information and design guide for glued structures will be provided. Techniques, skills and tools developed will be tested on three real scenarios. The selected machines cover a wide range of requirements to analyse the possibility of generalisation of the solution provided to other machines and even other sectors (railbodies, cars, lifts, etc) that deal with similar problems (energy saving, noise and vibration control, production costs, etc.).