RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Genetics-driven targeted therapy of Hairy Cell Leukemia' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Hairy Cell Leukemia (HCL),  a chronic B-cell neoplasm, is initially sensitive to chemotherapy with purine analogs, but ~40% of patients eventually relapses and becomes less responsive to these drugs. Furthermore, purine analogs may cause myelotoxicity, immune-suppression and severe opportunistic infections. Therefore, molecularly-targeted less toxic drugs are highly desirable in HCL. However, its low incidence and the initial efficacy of purine analogs has made HCL an orphan in the world of cancer research and has spoiled the academic and industrial interest in developing better treatments for this disease. But recently we identified the V600E activating mutation in the BRAF kinase as the key genetic lesion of HCL (similar to BCR-ABL1 in chronic myeloid leukemia). Orally available specific BRAF inhibitors (e.g., Vemurafenib) have in the meantime showed remarkable efficacy in melanoma patients harboring the BRAF-V600E mutation, although resistance to such drugs eventually develops in this malignancy through reactivation of MEK (the downstream target of BRAF). The ground-breaking objective of this project is to introduce for the first time in HCL, by means of phase-2 investigator-driven pilot clinical trials, the concept of BRAF and/or MEK inhibition as an oral, non chemotherapy-based, entirely out-patient, genetics-driven and rationally designed treatment strategy, first in patients with active disease despite (or severe toxicity from) previous chemotherapy with purine analogs, and then, potentially, in the frontline setting. In comparison to melanoma, deeper and longer effect of BRAF inhibition may be expected in HCL, due to its much lower genetic complexity and proliferation rate. Anyway, potential mechanisms of resistance will be searched for to identify other genes r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Instant Mobility for Passengers and Goods' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The Instant Mobility project has created a concept for a virtual Transport and Mobility Internet", a platform for information and services able to support radically new types of connected applications for scenarios centred on the stakeholder groups:\tmultimodal travellers\tdrivers & passengers\tpassenger transport operators\tgoods vehicle operators\troad operators & traffic managers.The project will define requirements for Future Internet technology tools and enablers, so that all these services will be available to any Internet-connected user, whether using a portable, vehicle-based or fixed terminal.These requirements will underpin a set of technical specifications for both domain-specific and FI enablers that will in turn be created as software conceptual prototypes for a virtual demonstration.The project will prepare a plan for implementing in Phase 2 some limited-scale trials in a number of real cities, using a Transport and Mobility Internet platform as subset of the full FI PPP core platform.Instant Mobility will also study the non-technical framework conditions that may support or hinder eventual deployment of FI-enabled online services in the T&M domain.The project will put forward its research results for support to standardisation, either for FI standards for standards in the T&M domain."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Monitoring suspended matter fluxes in coastal waters using ocean colour remote sensing and transport modelling. An integrated approach' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project aims to develop an operational monitoring system for turbid estuarine and coastal waters. The system combines in-situ observations, ocean colour remote sensing measurements and numerical transport modelling. In-situ and remote sensing (satellite and/or airborne) observations are directly integrated into a sediment transport model.This integration approach is used to calibrate the model and calculate sedimentary fluxes. The integrity of new quantification algorithms for ocean colour remote sensing sensors is first assessed in two European estuarine environments. These algorithms include recently developed atmospheric correction methods and suspended particulate matter (SPM) quantification relationships.The integrity assessment is based on multiple match-ups (simultaneous remote sensing and in-situ measurements). Once assessed, algorithms are routinely applied to multi-scale satellite data in order to observe the tidal and seasonal movements of surface SPM concentrations in a selected study area. The retrieved concentrations are associated to a quantified percentage of error. Remote sensing observations are complemented by numerous in-situ measurements providing information on the continuous variations and vertical profiles of turbidity.The generated database covers one full year and provides information on the tidal and seasonal SPM dynamics. Data (SPM concentrations) are integrated into a three-dimensional sediment transport model. In-situ and remote sensing data are first integrated separately to assess their respective influence in terms of model calibration (calibration of the empirical parameters used in the sediment transport model).The full dataset is then integrated. The final product (sediment transport model with data-integration) is used to obtain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Study of molecules involved in the secretory process of dense granules of toxoplasma gondii' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The regulated secretory process appears to be essential for the succes of Toxoplasma. as an intracellular parasite. Moreover, this parasite represents a very interesting model for secretion studies since three different regulated secretory organelles are found within one cell. This suggests that the secreted proteins have to be sorted toward the right organelle. We are now studying the targetting of the GRA proteins in the dense granules. we have identified in GRA proteins a conserved and specific peptide sequence. We presently test by transfection experiments of Toxoplasma the involvment of this sequence in targetting a reporter protein in the dense granules.  To study in more details the sorting process in Toxoplasma, we propose identify molecules which interact with GRA proteins. This work will be performed in the two-hybrid system in yeast. Four of the eight GRA genes that have been cloned in our laboratory will be used in yeast in the two-hybrid system (i) to study the possible interactions between GRA proteins themselves and (ii) to identify regulating proteins involved in their intracellular trafficking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of Adequate Cementing Materials Adapted To Novel Techno logies in Drilling and Completion'.

assistant: **Concept**

- Knowledge development on sulfate stability of ultrafine cement and stability of light weight cement in presence of glass sphere extenders and basic research development on phenolic resins- Formulation development: Elaboration of light weight cements blend formulation applicable for oil field well conditions with classical additives adjustment and recommendations on use of resin systems based on phenol group- Operational test: field tests were performed with the new formulations and confirmed of a good workability of ultrafine cement blend without any problems of mixing and segregation.The need for better economics, higher productivity, environment protection and more efficient and safe operations pushed the oil and gas industry towards the development of novel drilling and completion technologies, like slimhole, coiled tubing and high precision plug operations. However, due to lack of adequate cementing materials and placement techniques, overall success and safety of cementing in these operations is limited (30% for plugs) or cannot be guaranteed (slimhole, coiled tubing). Oil and gas companies have, therefore, a strong need to extend current cementing technology in terms of formulations and implementation techniques, in order to take full advantage of the underlying benefits in costs reduction, increased operations efficiency, productivity and environmental impact. Manufactures and service companies that perform cementations are forced to react on new tendencies and developments, in order to be able to provide materials and services with the necessary properties and quality. The objective of the project is to develop adequate formulations for application of the aforementioned technologies from 3 alternative chemical systems: thermoset resins, mud cement systems and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Application of smas in the Quarries for a novel splitting system'.

assistant: **Concept**

The expected deliverables have been actually reached and six advanced prototypes have been designed and produced. Each splitter is composed by two steel shells with the seats for the actuators, the SMA cylinders, and the heating system for the activation. The shells have been designed for a homogeneous distribution of the forces produced by the actuators and for an optimal exploitation of the required displacements for rock fracture initiation. The updated configuration of the prototypes has been studied to make possible the positioning of two or more systems in series into a single borehole. The number and the optimal positioning of the splitters along the splitting line has been defined on the basis of the results of numerical simulations by using a numerical model.Each splitter hosts a maximum number of nine actuators characterised by the development of high forces (which is the most critical parameters, rather than the displacement, as demonstrated by laboratory trials), and use reproducibility. The industrial objective of this project is to develop a splitting system (SMAQ) to provide the SMEs of the quarrying sector with a cost-effective and efficient working tool for the extraction of stone blocks through stitch drilling. Increased performance levels are predicted to yield a 20 percent cost saving and up to 30 percent increase in production with respect to traditional systems. Stitch drilling is a method used in most quarries to extract a block of regular dimensions and shape. In stitch drilling, a series of holes are drilled along the splitting line. The stone is then dynamically split along this line by means of'soft" explosives or by means of wedges driven into the holes with hammers. Alternative static solutions are the use of hydraulic systems or the use of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inter-domain management with integrity' (TRUMPET) under Fourth Framework.

assistant: **Objectives**

The project aims to develop and verify, by means of trials in real environments, mechanisms which will ensure the required integrity of inter-domain access to TMN based management systems. Access in this context includes both inter-TMN access and User to TMN access. Constituent objectives are:to propose a policy and techniques to guarantee the integrity for communication and information in an inter-domain, multi-provider management environment including user access to managementto select the appropriate mechanisms from the emerging standards to support inter-TMN security with open interfaces and to design and construct these mechanisms within scenario environmentsto validate the proposals and mechanisms by two trials involving TMN domains in National Hosts, connected networks and real users with managed applications and network components.to disseminate results to a wide audience and to influence the ongoing standards process by contributions to standardisation bodies.Specification of security policies for TMN interactions.Specification of a security architecture for both research and commercial TMN platforms.Specification of trial scenarios involving tele-medicine applications over ATM connections.Contribution to ETSI NA4 (security policies and security architecture) for the standardisation of TMN security.Establishment of close collaboration with ACTS MISA project including a common trial scenario.Proposal for collaboration with the newly created EURESCOM P710 project on TMN security.Expected ImpactIn the Global Information Infrastructure there will be a multiplicity of network providers, service providers, value added service providers as well as sophisticated users, all with their own management systems. To ensure that these management systems can inter-operate in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HADES - Optical Hot Air Leak DEtection System' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Light carbon structures are increasingly used in modern aircrafts for reducing weight and thus fuel consumption. The carbon materials are more sensitive to overheating than metals. Hot air ducts are used to conduct air heated by engine exhaust to the cabin heating system. At several locations, those hot air ducts are installed within or in close proximity to the carbon structures. Therefore, reliable and precise hot air leak detection is an essential safety feature of modern aircrafts. The proposed activity aims at developing an innovative, powerful and reliable fibre-optic technology for an aircraft hot air leak detection system and validating it in a representative aircraft environment.State-of-the-art electrical hot air leak detection systems detect and localize leaks in aircraft hot air ducts by analyzing electric shortcuts. However, the response of such systems just indicates that the critical temperature is exceeded. It is impossible to vary the threshold setting along the cable and false alarms due to stray signals are common. Localization of leaks is difficult and the sensor cables are irreversibly damaged by exceeding the critical temperature.Based on our deep understanding of using fibre-optic sensing systems in harsh and safety-critical environments, LIOS will select the optimum fibre-optic technology for hot air leak detection in aircrafts, which overcomes the limitations of the electrical systems, complies with the requirements of the tender and fulfils the other essential requirements of aircraft applications. LIOS will demonstrate the technology’s capabilities, using a proof-of-concept system in the LIOS laboratories. After testing, we will re-design the demonstrator to enable a demonstration within an aircraft environment, allowing to pass the respective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Euro GO-SHIP: developing a Research Infrastructure concept to support European hydrography' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Observations from ships, and in particular water column measurements, remain the backbone of much Oceanographic Science, including fisheries, regional oceanography, and global climate science. Every coastal country in Europe has a programme of such observations that feeds data into evaluations in support of the Marine Strategy Framework Directive with these programmes being organised into both regional clusters and serving as contributions to wider international networks. In 2019, as part of the OceanOBS conference,  networks identified gaps in their requirements for support and here we propose a programme to address these requirements within the context of the European RI landscape. The proposed new services and access opportunities based on the network needs presented at OceanOBS are:•shared facilities such as training, best practices, access to capability and access to equipment through a European Marine Equipment Pool (EMEP)•data curation to ensure fit for purpose data systems and metadata for both real-time and delayed mode quality-controlled data•secondary quality control to increase consistency and add uncertainty estimates to observations. These will be refined by broad consultation with data originators, governments, funders and end-users. In addition, pilot activities will both provide immediate support to the networks and help to refine a statement of requirements. These requirements will be compared to the set of services already available within the European RI Landscape and on the basis of this a new structure for supporting European Hydrography proposed. Possible models range from complete service delivery within existing RIs and the establishment of no new structures through to the creation of an RI with a set of services unavailable elsewhere.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhancing Human Capacities: Ethics, Regulation and European Policy' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Biotechnologies may be applied to make people think better, feel happier, live longer or to improve their functioning in sports. These enhancements of human capacities have their roots in the healing of illness and the relief of suffering, but have come t o a second use in the efforts to improve human feeling, mind and physical performance. These dual-use technologies raise not only ethical questions about potential, but also about their consequences on our self-understanding, our society and the goals of (bio-)medicine. The goal of the project is to reach a deeper understanding of the ethical and philosophical issues of the use of emerging technologies beyond the purpose of therapy. The project will focus on four areas: cognition, mood, physical performan ce in sport and life-extension. The ethical research will be based on in-depth scientific understanding of the new technologies, supplied by leading experts in the field of neurosciences, biology and bio-gerontology. The project will have as objectives: 1. To document current and imminent scientific advances that may enhance human capacities in cognition, mood, physical performance (in sport) and ageing. 2. To evaluate these advances from a philosophical, ethical and social perspective. 3.To facilitate polic y-making to the emerging dual-use technologies. 4.To promote public understanding of dual-use technologies and the ethical debate. The project will combine literature search, workshops and a conference to reach the objectives of the project. The results wi ll be communicated by academic publications, popular articles and a website. The project concentrates on one of the topics under 4.3.2.3 of the Work Programme Science and Society 2004, Deepening the understanding of ethical issues: research to enhance huma n men