RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular Mechanisms underlying the link between the vitamin K-dependent proteins, Gas6 and protein-S, and phagocytosis of apoptotic cells during cell differentiation processes' (PHAGOCYTOSIS) under Seventh Framework.

assistant: **Objectives**

The anti-coagulant factor protein-S and its structural homologue Gas6, two vitamin K-dependent proteins, are ligands for the Tyro3/Axl/Mer family of related tyrosine kinase receptors. Protein-S is the major factor responsible for serum-stimulated phagocytosis of apoptotic cells. The phenotypes associated with the invalidation of genes encoding Tyro3/Axl/Mer, further revealed the implication of protein-S and Gas6, in regulating apoptotic cell phagocytosis.  We hypothesise that protein-S and Gas6 as well as other vitamin K-dependent proteins are major regulator of apoptotic cells phagocytosis, which is a critical step during cell differentiation. We intend to use Gas6-deficient mice, as well as RCS rats (deficient in Mer receptor) to investigate further the role of protein-S and Gas6 and possibly other vitamin K-dependent proteins in regulating cell differentiation and phagocytosis  in three in vitro models of cell differentiation: retinogenesis, neurogenesis and spermatogenesis. The signalling pathways regulated by these factors and which are involved in mediating phagocytosis will also be investigated. The present research proposal also aims at setting up and standrising an in vitro quantitative assay for phagocytosis which will be a major technical advance and may form the framework for “phagosomics” as a new high-throughput screening assay to assess phagocytosis. Therefore, the present proposal may be of interest for also biotechnology companies. This research proposal will also contribute to establish possible links between the AVK anti-thrombotic treatment and retina degeneration, neurodegeneration, altered spermatogenesis/infertility.  The link between blood coagulation factors and phagocytosis will be a new concept of major importance and will contribute to a bett
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Promoting Active Ageing: Developing Age-Friendly Cities' (AGE-FRIENDLY).

assistant: **Innovation**

Need for the research: Although the issues raised by the 'age-friendly city' movement are well-understood at the level of the World Health Organisation and European Union, awareness within relevant academic disciplines is still limited. This project will fill a major gap in the literature by providing a substantial research base for assisting the development of age-friendly cities.Host and researcher: The proposed fellowship is a collaboration between a world-class scientist working at the University of Manchester, UK (Prof. Chris Phillipson) and an ambitious post-doctoral researcher currently based in Belgium (Dr. Tine Buffel). The research fellow, Dr. Tine Buffel (Vrije Universiteit Brussel), is one of Belgium’s most accomplished young researchers in the field of ageing. The host, Prof. Chris Phillipson has been a key figure in the development of social gerontology, and is one of the world’s leading researchers with expertise in population ageing and urbanization.Interdisciplinary nature: A key objective of the fellowship includes the development of an interdisciplinary approach to studying age-friendly environments. An interdisciplinary project team and advisory board will be formed to support and develop the career progression of the fellow. Both will comprise leading international researchers working across a range of disciplines (including social geography, psychology, environmental gerontology, urban design, architecture, and epidemiology) relevant to developing age-friendly cities.Benefits to Europe: Promote healthy and active ageing in Europe; contribute to European excellence regarding research on population ageing; advance Europe’s competitiveness by involving older people in research and innovation; provide outreach activities which will be beneficial to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Keelcrab the Drone for an automated hull cleaning: fast & essential', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The underwater drone KeelCrab SailOne is the first R.O.V vehicle for the care of your hull entirely designed and built in Italy.Fast, lightweight, practical, user friendly, you can easily reduce the consumption of your boat keeping your hull in a perfect statewith top performance. KeelCrab will contribute to stop usage of polluting antifouling paints and open the way for green solutionswith a safe respect for the environment and your wallet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flourishing Seeds. Value Creation and Relatedness in Agrobiodiversity Hotspots' (SeedsValues), addressing dissemination and exploitation.

assistant: **Impact**

AgricultureAgriculture condenses the most pressing challenges we are facing today: ecological degradation, financial deregulation and demographic explosion. Value discrepancies are key obstacles toward integrated agriculture which are not rewarding in the capitalist economy overwhelmed by a profit-driven agroindustry. However, we still lack fundamental knowledge to identify the manifold values of agricultural assets. While the value of crop varieties is usually assessed in economic terms, we need to also consider the ethical values that incentivies farmers to perpetuate biodiverse agriculture.   Beside empirical timeliness, this study contributes to the elaboration of a general anthropology of value still lacking to date. The SeedsValues contends that agriculture offers a unique object to overcome the current split between the economic and the ethical studies on value. This will be achieved by producing interspecies ethnographies into seed-human relatedness - both affective and instrumental - in three agrobiodiversity hotspots: potato cultivation in Peru, maize in Mexico and rice in Laos. Prominent on global markets, also distinguished by international institutions as highly promising to reach global food security, these crops bear outstanding value to the Indigenous people who cultivate and eat them daily. Sometimes, they are treated as organisms imbued with a subjectivity, challenging Western dichotomies between object and subject, nature and culture. In this light, this project aims at unravelling (a) the ethics of seed growing, (b) the appreciation of seeds in exchange and consumption, and (c) the entanglements between growers' and seeds’ qualities.  Beside addressing critical ecological questions regarding the sustainable feeding of an increasing human population,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling the Physics of Light at Scale' (UNRAVEL).

assistant: **Innovation**

Earth climate research crucially depends on measurements of the atmospheric distribution of CO2, which is largely obtained using satellites. But satellites cannot directly measure CO2—they capture photographs at different wavelengths that must be mathematically processed to obtain this information. Current methods for solving this inverse problem are unaware of many aspects of the images including topography, cloud shape, shadowing, etc. The UN Intergovernmental Panel on Climate Change (IPCC) has identified the resulting errors as the main cause of discrepancies between different climate sensitivity models.This proposal in the area of computer graphics introduces methods for inverting the physics of light at unprecedented scales that will address these inaccuracies. However, the scope of our contribution extends far beyond climate modeling: it will have a revolutionary impact on all scientific disciplines that involve the analysis of images, including biology, computer vision, architecture, and many others.In this project,- we will establish the first  framework for inverting light simulations with billions of parameters.To demonstrate its generality, and to realize the impact of this framework, we will specialize it to three areas:- we will develop the first invertible atmospheric optics simulator for earth climate monitoring that accounts for 3D structures, addressing severe inaccuracies of current  methods. - we will create an invertible virtual microscope that will open the door to fundamentally new reconstruction techniques in the area of biology.- we will design architectural light simulations that are able to adapt buildings so that they make ideal use of naturally available daylight. To achieve these goals, we must unravel the messy physics of light to either re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting the regulation, structural dynamics, and physiological role of human Ninj1 activity during Mtb-induced cell death on a molecular scale.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Mycobacterium tuberculosis (Mtb) causes tuberculosis a leading infectious killer worldwide. Mtb primarily infects macrophages, leading to the death of some of these cells via distinct regulated cell death (RCD) mechanisms. While apoptosis facilitates Mtb elimination, necrotic cell deaths, like pyroptosis, necroptosis, and ferroptosis may enhance bacterial replication and spread. Mtb effectors, including the type VII secretion system ESX-1 and the cell wall lipid PDIM, induce host membrane damage, inducing necrotic cell death. Notably, the host lab has shown that inhibiting all RCD pathways does not prevent Mtb-induced cell lysis. However, depleting Ninjurin-1 (Ninj1), a membrane protein vital for plasma membrane (PM) rupture during various RCD pathways, mitigates Mtb-induced necrosis. Ninj1 oligomerization appears to occur after initial PM integrity disruption, yet the precise mechanisms governing Ninj1 activation and its role in Mtb-induced cell lysis remain unclear. I hypothesize that Ninj1 plays a crucial role in Mtb-induced lysis and that Mtb exploits this process through effector-mediated PM permeabilization. To investigate how Ninj1 oligomerization influences cell fate and the inflammatory response, I will leverage my expertise in super-resolution microscopy of pore-forming proteins alongside the host lab’s skills in Mtb infection biology. First, I will identify PM chemical and physical changes during RCD that correlate with Ninj1 oligomerization to elucidate the activation mechanism. Next, I will analyze Ninj1 dynamics and the functional impact of its macromolecular structures using DNA-PAINT super-resolution microscopy and long-term single-molecule tracking. Finally, I will determine whether Mtb activates Ninj1 via effector-induced PM damage and quantify the imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced decision support system for chemical/petrochemical manufacturing processes' in the context of a Fifth Framework call.

assistant: **Objectives**

CHEM will build flexible and integrated software allowing advanced and specialised software tools to collaborate to improve operations in refining, chemical and petrochemical processes. The aim is to : use information available on industrial plants, avoid unscheduled shutdowns and abnormal situations and determine optimal states and how they can be reached. Advanced Decision Support System will be a synergistic integration of new software tools for process monitoring, data and event analysis, and operation support developed in Europe and world-wide. A methodology will be proposed so that new supervision applications can be easily developed on various processes. Considering the economic loss and damage due to abnormal situations, the project will have large impacts on economy, safety and environment protection. It will improve working conditions by helping operators in daily work and increasing level of knowledge of the process.The 23 toolboxes addressed by the project and dedicated to the tasks listed before are available. A methodology defines how the different toolboxes that were developed can be used individually and together so that, in the future, new supervision applications can be easily built on different processes. An integration platform was built for allowing easy communication between the toolboxes. It was validated on CHEM toolboxes and can be extended to other software tools. It relies on an information model, which allows the sharing of information in an XML form. XML, Message Oriented Middleware, Corba, Java are being employed jointly with G2, a commercial proven platform for developing complex industrial applications. The platform allows interfacing with commercial plant databases and process control software. The toolboxes and sets of toolboxes integra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exoplanets', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The EXoPlanetary Observational Research Team (EXPORT) was awarded 100% of the international observing time of the Canarian observatories in 1998 for their Planetary Systems: Formation and Properties" project. The excellent instrumentation and observing conditions throughout the observing campaigns enabled them to amass a quite unique database with regard to the formation and evolution of exoplanetary systems, the study of the giant exoplanets of nearby stars and the search for new exoplanets. The results obtained will be presented to the international astronomical community in a conference entitled "Disks, Planetesimals and Planets" to be celebrated at Puerto de la Cruz (Tenerife) from 24 to 28 January 2000. This conference will also serve to contrast our findings with those made in other wavelength regions by other groups at other ground-based and space-borne facilities and will provide a synthesis of present-day knowledge in the field of exoplanetary formation and evolution, which is now such a timely scientific topic and one which is much in the public eye."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reconstructing wiring rules of in vivo neural networks using simultaneous single-cell connectomics and transcriptomics' to be submitted under Horizon 2020.

assistant: **Abstract**

The brain performs sophisticated functions and complex behaviours, orchestrated by highly specialized cells. Neurons are at the core of the nervous system’s computational capabilities. In recent years, we and others have advanced single-cell RNAseq to reveal their extraordinary molecular diversity in transcriptome-based cell-type taxonomies. It is the unique combinations of circuits that these different neuronal types form – within a practically unlimited space of possible implementations – that encode the large functional repertoire of the nervous system. Although critical, little is known about the basic organizational principles of cells within the circuits – the ‘wiring rules’. This highlights the conceptual challenge to measure connectivity on a systematic and synaptic, single-cell level. What is the topology of networks? What is the relation between network topology and function? How do cell types and gene expression determine wiring? Answering these questions will help resolve nervous system computation at the level of its cellular building blocks. The vision of this proposal is to provide and apply a novel approach that will allow us to investigate neuronal connectivity at large-scale. Two key requirements for such measurements are the ability to measure true synaptic connections, and obtain tens of thousands of datapoints. Further, the concept of cell types is crucial for addressing the connectivity problem, as it allows us to distinguish the network elements and thus assemble a global picture even from fragmented, partial measurements. For this purpose, we will combine transcriptomics and connectomics measurements at the single cell level. The proposed project has enormous potential to systematically (re)address basic functional questions in neuroscience. It c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Common Oncogenic Mechanisms in Multi-Partner Translocation Families in Acute Myeloid Leukemia'.

assistant: **Innovation**

Acute Myeloid Leukemia (AML) is the most frequent cancer of the blood system, with >80% mortality within 5 years of diagnosis. Straightforward clinical decisions are complicated by the genetic complexity of AML. In particular, fusion proteins arising from chromosomal aberrations are recurrently found in AML and often act as strong driver oncogenes. In “Multi-Partner Translocation” (MPT) families, one specific gene is fused to many recipient loci. Due to this modular architecture, MPT families are of particular interest to comparative studies of oncogenic mechanisms. The three most common MPT families in AML represent translocations of the MLL, RUNX1 and NUP98 genes. Despite their clinical significance, the molecular mechanism of transformation remains unknown for the majority of fusion proteins and it is unclear if transforming mechanisms are conserved within and across different MPT families.We hypothesize that common oncogenic mechanisms of fusion proteins are encoded in physical and genetic cellular interaction networks that are specific to MPT families. We propose to delineate critical common effectors of oncogenic mechanisms in AML driven by MPT families through a comprehensive, comparative, functional analysis of 20 clinically representative MLL-, RUNX1- and NUP98-fusion proteins using a unique experimental pipeline. Characterization of protein interactomes and their effects on gene expression will identify common cellular denominators of MPT families, whose functional contribution will be assessed through pooled shRNA screens in clinically relevant model systems. High-confidence hits will be validated in mouse models and primary cells from AML patients. This project will generate large informative datasets and novel experimental systems that are of relevance for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The effect of stellar magnetic activity on protoplanetary discs and exoplanet detection' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Many cool stars are born as rapid rotators, and therefore with a strong dynamo created magnetic field, which manifests itself as a high level of activity including strong flares and coronal mass ejections. This is the environment in which planets are formed, and it is therefore unavoidable that this activity has a significant impact on the formation and evolution of planetary systems.  The phenomena caused by stellar activity can also have similar effects on stellar brightness and radial velocity as orbiting planets, making it at times difficult to distinguish between planets and activity signatures, especially when using radial velocity searches to find small Earth sized planets. Today we have a unique opportunity to address these points with the new upcoming European and global observational facilities (Atacama Large Millimetre/sub-millimetre Array and Stellar Observations Network Group). In this project we suggest two main lines of investigation:1) Constructing a freely available database on expected effects of the activity on the detectability of the exoplanets using different methods. We will build a realistic model of activity patterns on different types of stars and using large range of stellar parameters. This model will be used to probe different activity cases, resulting in a database of activity patterns and likelihood of them mimicking different types of exoplanets. This will be crucial for detectability of small, Earth mass, planets using long-term radial velocity measurements with SONG.2) Studying the effect of the stellar magnetic activity on the protoplanetary discs. By using mid-infrared and sub-millimetre observations of active and non-active young stars with discs a comparison of the disc properties in these two types of stars can be made. We will stu