RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Optical dissection of prefrontal neuromodulation: from synapses through networks to behavior'.

assistant: **Concept**

The neocortex is organized into neural circuits that perform distinct computations, from sensory processing and motor control to memory, learning and language. Neuromodulatory systems projecting to the neocortex exert a powerful influence on cortical computations through neurotransmitters such as acetylcholine, monoamines and neuropeptides. The prefrontal cortex (PFC), a cortical region required for working memory, attention and goal-directed behavior, receives dense projections from multiple neuromodulatory systems that dramatically impact its function. Pioneering work has shown that pharmacological manipulation of these systems can potently modulate attention and cognitive function and that impaired neuromodulation can lead to psychiatric disease. Yet, much of the view of high level cortical function is focused on models that either ignore neuromodulation altogether or treat it as a reward or arousal signal.We propose to elucidate the dynamics and mechanisms of prefrontal neuromodulatory tuning, from the level of synapses and cells to circuits and animal behavior. To achieve this goal, we will map the circuit-level impact of synaptic neuromodulatory inputs on the prefrontal cortex circuit dynamics, develop and apply two novel optogenetic approaches for light-based synaptic silencing and optical recording of cortical neuromodulatory activity in vivo, and establish the causal roles of PFC neuromodulation in attention and working memory. These experiments will enable us for the first time to delineate the specific contribution of distinct neuromodulatory systems to prefrontal function, integrating comprehensive cell- and circuit-level analysis with unique opto-physiological readouts in behaving animals. The project will yield an integrative view of prefrontal neuromodula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of genome regulation in the origin of animals' (PREMETAZOAEPIGENOME) under Horizon 2020.

assistant: **Objectives**

The goal of this proposal is to understand how animals emerged from their unicellular ancestors. It is clear that the role of the genome regulation at the level of chromatin organization plays a crucial role in cell type specification, a hallmark of animals. However, how these genome regulatory mechanisms arose and whether they were already present in the unicellular ancestor of animals remains an open question. So far, there is minimal information to address this question from a comparative point of view. To fill this gap, we will characterize histone modifications, DNA methylation and open chromatin regions in one of the closest unicellular relatives of animals, an ichthyosporean Creolimax fragrantissima, which exhibits a multicellular-like developmental cycle. In particular, we will carry out a comprehensive genome-wide analysis of histone modifications by ChIP-Seq, ATAC-Seq, as well as techniques for detecting the distribution of 6-methyladenosine DNA marks, during the developmental cycle. In parallel, we will also investigate the Myc transcription factor network. Myc, along with its partners Max and Mad have been discovered in unicellular holozoans, suggesting that the network has already regulated cell proliferation and differentiation in the unicellular ancestor of animals. We will detect the genomic targets of Myc, Max and Mad proteins by performing ChIP-Seq. To complement these results with functional studies, we will develop genome editing tools in Creolimax. The data and the comparative analyses will provide significant insights into the nature of the regulatory genome of the last unicellular ancestor of animals. Specifically, we will learn whether the last unicellular ancestor already possessed features of complex genome regulation, such as distal enhancers,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced rheologic & tribologic characterisation of micro/nano scale fluid films and solid thin films.' under Fifth Framework.

assistant: **Concept**

Miniaturisation in microelectronics, microsystems and micro analytical methods in many fields increasingly need characterisation of fluid or solid thin films at micro / nano scale. Functional properties of contact surfaces are of special relevance. Material parameters taken from macroscopic measurement are not valid at micro / nano scale due to unproportional influence of surface forces and substrate microstructures. This is especially true for rheologic and tribologic properties. Despite existing needs no according measuring equipment is commercially available. The project therefore aims at developing an automated equipment for micro force &micro torque measurement for analysis of nanoscale fluid / solid films and µl-scale fluid specimen. The modular system will be integrated with precision micro drives. The project includes development of calibration standards. SME proposers who are active in sensor technology and laboratory equipment expect substantial market volume from the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modeling of partially spatially coherent distributed sources: derivation of an extended reciprocity theorem, creation of a numerical tool and experimental validation.'.

assistant: **Innovation**

Going up to infrared or optical frequencies, classical antenna technology fails due to the lack of efficient localized feeds. At such frequencies, emitters generally rely on distributed feeds. Each point of the extended source zone emits fields randomly, so that the total fields generated by the device are only partially spatially coherent. The partially spatially coherent aspect of the fields has received limited attention so far, especially in the engineering community. However, it is well known that the spatial coherence of the fields plays a key role in shaping and enhancing the radiation from thermal and electroluminescent sources. In this project, we propose a framework where the fields emitted by such sources are decomposed into an incoherent sum of fully coherent modes. During this project, we will develop a versatile open-source software that can simulate such devices using a full-wave integral equation method. This software can be used to study thermal or electroluminescent emitters of various geometries while rigorously accounting for the partial coherence of the fields. The software will be validated through experiments and shared with the community. Using the modal framework, an extended reciprocity theorem between the fields emitted by thermal or electroluminescent sources and the fields they absorb that includes the partially coherent aspect will be derived and validated through experiments. This project is expected to deeply impact the field since no such tool that can rigorously account for the partial coherence of the fields has been proposed so far. Moreover, the experimental characterization of emitters will be easier using the extended reciprocity. This project will be done in the University of Cambridge in collaboration with J.-J. Greffet (France)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'REnewable FunctIoNal matErial –  Training material scientists for a sustainable polymer industry' (REFINE) under Seventh Framework.

assistant: **Objectives**

The plastic industry contributes around 23% of the total sales in the European chemical industry but is traditionally heavily reliant on petrochemicals for their raw material, additives and reaction media (solvents). REFINE will develop sustainable routes to functional materials (green routes) for various polymer/plastic applications. The network will make use of integrated approaches combining green raw materials, green synthesis (biotechnology) and green processing. This will be complemented by critical life cycle analyses and end-user benchmarking. The network will demonstrate these concepts by targeting selected relevant industrial applications, which are fundamentally dependent upon polymers such as thin film applications (coatings, personal care, etc.).Its leading experts in polymer and material science and biotechnology from 6 academic and research institutions, 2 multinational industrial end-users from different application areas (performance polymers and personal care products) and 1 SMEs will make use of integrated approaches combining green raw materials, green synthesis and green processing. These three elements will systematically be linked in a chain of knowledge approach and complemented through critical life cycle analyses by an SME with specific expertise in ecological process evaluation.The REFINE network will train a new generation of materials researchers, who are aware of the envi-ronmental impact of their work and can apply the tools of sustainability in their future positions (sustainable materials scientists). It will positively impact the employability of its researchers in the bioplastic industry with a predicted growth of >25% by 2020 by giving them a unique combination of skills through scientific, industrial and individual training at the lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Agent-Based Modelling of Gene Networks to model clonal selection in the tumour microenvironment and predict therapeutic resistance' in the context of a Horizon 2020 call.

assistant: **Objectives**

The occurrence of therapeutic resistance is a major cause for the small effect on overall survival showed by targeted cancer therapies. Whilst experimental strategies to evaluate available treatments have been faced by an ever increasing number of possible combinations, computational approaches have been challenged by the lack of a framework able to model the multiple interactions encompassed by the three major factors affecting therapeutic resistance: selection of resistant clones, adaptability of gene signalling networks, and a protective and hypoxic tumour microenvironment.Here I propose a novel modelling framework, Agent-Based Modelling of Gene Networks, which brings together powerful computational modelling techniques and gene networks. This combination allows biological hypotheses to be tested in a controlled stepwise fashion, and it lends itself naturally to model a heterogeneous population of cells acting and evolving in a dynamic microenvironment, which is needed to predict therapeutic resistance and guide effective treatment selection.Using triple negative breast cancer (TNBC) as a testing case (15% of breast cancers, lacks validated), I propose to: 1. Develop a computational model of the TNBC tumour microenvironment using in-vitro and in-vivo, including patient-derived, models and data from clinical samples. 2. Validate the ability of the model to predict driver genes conferring a survival advantage to cancer cells in a hypoxic microenvironment. 3. Predict combinations of druggable targets to tackle TNBC therapeutic resistance. 4. Select most effective drug combinations and validate pre-clinically.This project will deliver pre-clinically validated drug combinations, new therapeutic targets and a virtual environment to study individual tumours and predict ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An integrated study of seismic hazard assessment in the area of aigion, gulf of corinth, greece' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Problems to be solvedThe aim of the project is to contribute to improve observational, experimental and theoretical methodologies for seismic hazard assessment. The work will focus in the highly seismic Aigion area, Gulf of Corinth, Greece. Tectonic studies with geomorphology, trenching, and coring in quaternary sediments, associated with dating, will provide information of long and mid term deformation and rupture sequences of the major faults. Continuous GPS will bring space and time variability of the strain field. Borehole and surface high dynamic accelerometers in soft soil sites will allow the study of non-linear effects. Continuous geophysical (strain, tilt, pore water pressure,) and geochemical monitoring will detect crustal transients, to be analysed together with seismicity. Scientific objectives and approach The tectonic studies consist of a detailed geomorphologic survey of the area, trenching on the two major fault scarps and dating of the rupture episodes, drilling at shallow depth (tens of meters) for dating of quaternary sediments. Long-term subsistence and uplift, as well as time series of rupture, will be analysed. The source seismological studies consist of deploying broadband surface accelerometers on rock sites, installing an array of shallow borehole velocimeters (100-150 m), and installing deep borehole high dynamic accelerometers (400 m and 100 m). For the engineering seismology and earthquake engineering studies, shallow boreholes drilled in soft soils will be equipped with high dynamic accelerometers. In site and laboratory dynamic tests will be performed to define soil profile with a detailed description of the dynamic soil properties. Finally, a buried structure will be instrumented with a few accelerometers. Experimental and theoretical anal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European conference on visual perception (ECVP 2003)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The European Conference on Visual Perception (ECVP) is an annual international conference dedicated to the fundamental and applied aspects of visual perception and promoting interdisciplinary interactions and innovative aspects in cognitive sciences among fields as diverse as neurophysiology, neural imagery, psychophysics, neuropsychological, AI, neural networks, philosophy and ophthalmology. The present proposal concerns ECVP 2003, to be organized in Paris, France. ECVP covers a wide range of themes in prosthesis- and cognitive sciences addressed by the means of electrophysiological, psychophysical and neural imagery techniques. Its typical audience is around 500, largely international (60% west-European participation), young (45% students & post-docs) and diversified (25 countries). ECVP is the only European conference in visual sciences and is considered as prestigious its American counterparts ARVO-VSS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Surrounded by Science: Learning paths towards science proficiency' (SURROUNDEDbySCIENCE).

assistant: **Innovation**

Every day, people of all ages are engaged in powerful science-related activities outside the classroom that spark interest and foster their understanding of science. However, it is not fully understood how outcomes of such activities relate to the outcomes of traditional formal science education. Surrounded by Science brings together experts in science education research, science centers and museum pedagogues, providers of outreach and informal learning activities, strong users communities, and policy makers to design and develop a systematic assessment methodology that will analyze the impact of out-of-school science activities. The project team will conduct a series of field studies and use innovative research instruments (Digital Toolbox) to support the data collection from citizens actively participating in science related activities to assess the impact of specific out-of-school activities. The project will integrate the collected information in matrices to advise science organizations in the design of their activities. Furthermore, the project will propose an accreditation scheme for science education providers and offer guidance on their effective integration to (formal) science education policies. In total, more than 10.000 participants will become part of the assessment, either by interacting with one of the selected activities or by participation in an in-depth assessment of their science proficiency. Surrounded by Science aims to have a long-lasting impact on the ability of science educators to design more effective, targeted, and meaningful learning activities at all levels. The Digital Toolbox is available to partners within and beyond the project, allowing them to evaluate and set up more effective activities to achieve meaningful impacts on learners? scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fish Population Structure and Traceability' (FISHPOPTRACE), addressing dissemination and exploitation.

assistant: **Impact**

Although exploited fishes have traditionally been managed on a geographic basis, for conservation purposes they should be managed at the population level: the extent and dynamics of population structuring underlies resilience and sustainability. More effective enforcement and conservation demands a focus on identification and monitoring of wild fish populations and traceability of products. FishPopTrace brings together expertise in fish traceability projects (Fish and Chips, FishTrace, FISH-BOL) to: 1.Integrate data from European fish species traceability projects, and to generate a single compatible database and tissue archive managed by the Joint Research Centre of the European Commission. 2. Examine single nucleotide polymorphisms (SNPs) and otolith microchemistry and morphometrics in widely distributed populations of cod, hake, herring and sole. Outputs will comprise population-level signatures associated with fish origins in early life and representative spawning groups. 3. Undertake validation of traceability tools in relation to end-user technology. 4. Develop a population monitoring system based on genetic and otolith data that will assess population stability in a temporal and spatial framework. 5. Test the utility of additional novel traceability systems (fatty acid profiles, proteomics, gene expression, microarray platform for SNP genotyping). 6. Facilitate technology transfer in relation to enforcement and conservation policies of the EU Common Fisheries Policy (CFP) and associated socio-economic consequences. Outputs from FishPopTrace will improve the traceability of fish and fish products and protection of consumer interests through enhanced understanding of the dynamics, temporal stability and distribution of major populations of four key exploited fish s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cracking the SUMO Signalling Code' to be submitted under Seventh Framework.

assistant: **Abstract**

Functional activity of proteins is tightly controlled via reversible post-translational modifications including phosphorylation, acetylation and ubiquitylation. These modifications enable the orchestration of cellular responses to a wide variety of stimuli. Due to these modifications, proteomes are overwhelmingly complex. Progress in the field has been greatly accelerated by the development of novel approaches to study these post-translational modifications at a proteome-wide scale using the sensitivity and robustness of mass spectrometry (MS). This has enabled the identification of thousands of dynamically regulated phosphorylation, acetylation and ubiquitylation sites by MS. The functional significance of these modifications is now being addressed worldwide at an unprecedented scale. In contrast, global understanding of ubiquitin-like signalling networks in a site-specific manner is very challenging.Over the last few years, my lab has established novel methodology for the purification and identification of endogenous SUMO target proteins and SUMOylation sites of endogenous targets. The first aim of this project is to uncover small ubiquitin-like modifier (SUMO) signalling pathways in a site-specific manner at a proteome-wide level.The second aim of this project is to reveal how SUMOylation cooperates with ubiquitylation to maintain genome integrity. SUMOylation plays a critical role during the DNA damage response, an important barrier against genome instability linked diseases including cancer and neurodegeneration. Selected target proteins will be studied at the functional and mechanistic level to obtain novel insight in cellular processes that protect against genome instability.The developed methodology is generic and can be applied to study all ubiquitin-like prote