RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Developmental and Genetic Analysis of DNA Double-Strand Break Repair'.

assistant: **Objectives**

The DNA within our cells is constantly being damaged by both environmental and endogenous agents; of the many forms of DNA damage, the DNA double-strand break (DSB) is considered to be most dangerous. Correct processing of DSBs is not only essential for maintaining genomic integrity but is also required in specific biological processes, such as meiotic recombination and V(D)J recombination, in which DNA breaks are deliberately generated. In animals, defects in the proper response to DSBs can thus have different outcomes: cancer predisposition, embryonic lethality, or compromised immunity. Many genes that play a role in the processing of DSBs have been identified over the past decades, mainly by cloning genes that are responsible for specific human genomic instability or immune deficiency syndromes, and by genetic approaches using unicellular eukaryotes and rodent cell lines. It is, however, evident that many components required in higher eukaryotes are not yet known and the identification of those will be a major challenge for future research. Here, we will for the first time systematically test all genes encoded by an animals genome directly for their involvement in the cellular response to DSB in both somatic and germline tissues: we will use our recently developed transgenic animal models (C. elegans) that visualizes repair of a single localized genomic DNA break in genome wide RNAi screenings to identify (and then characterize) the complement of genes that are required to keep our genome stable, and when mutated can predispose humans to cancer. In parallel, we will study the cellular response to single DNA breaks that are artificially generated during different stages of gametogenesis, as well as address the developmental consequences of DSB induction during the ear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An investigation into the differential mechanisms and regulation of leukocyte clearance from the human lung across two distinct barriers: the bronchial epithelium versus the alveolar epithelium' (2007-2013).

assistant: **Concept**

Inflammation of the lung is central to the pathogenesis of most respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), pulmonary fibrosis (PF), cystic fibrosis (CF) and pneumonia. Leukocytes traffic through normal lung for immune surveillance; but these numbers increase in response to toxins or pathogens and can be overwhelming. Leukocytes can exit from the lung interstitium across the bronchial epithelium, into the airway lumen by a mechanism called “luminal clearance”. This mechanism is dependent on the co-ordinated leukocyte adhesion to sequential epithelial cell surface molecules and prevent excessive airway inflammation. In contrast, migration of leukocytes across the alveolar epithelium is hazardous. Leukocyte migration into the alveolar space underlies the pathogenesis of lung diseases such as pneumonia and PF. However, despite their importance very little is known of these two distinct trans-epithelial pathways. This project will examine the distinc regulation of leukocyte clearance across these two epithelial barriers (bronchial and alveolar) using a novel in vitro human model system. This work will then be extended to animal models of human disease, and in particular a murine model of PF, well established at UCL. Finally, confirmatory findings will be sought in human patient studies. An IEF will allow Dr Rebeyrol to bring her expertise on lung epithelial inflammation gained during her studies in CF, to our UCL laboratory, and she will, in turn, acquire a working knowledge of in vitro and in vivo models of leukocyte migration in the healthy and diseased lung. An IEF will be central to her developing the foundation to establish her own laboratory to continue important work into novel therapies for CF and other inflammatory lung dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chain Reaction: A Sustainable Approach to Inquiry Based Science Education' (CHREACT).

assistant: **Innovation**

Over the last decade a sharp decline in interest and participation in science has been identified in young people across Europe.  Should this continue, the capacity to innovate both in industry and research will suffer in the long term.  A critical issue in addressing this problem is providing young people with relevant contexts and practical experience of scientific concepts through classroom science.  Therefore, the development of Inquiry Based Science Education (IBSE) and active teaching and learning approaches has never been more important.  The Chain Reaction project aims to capitalise on a previously successful approach to delivering IBSE in the UK in an attempt to embed IBSE practice within European schools.The key aim is to equip teacher educators to train teachers across twelve countries in the use of IBSE materials and techniques.  Each country will adapt materials and techniques for use in their own country, addressing issues of different curricula and cultures as necessary. This will ensure that each partner will have ownership of resources and classroom techniques suitable for their own situation and contexts, but based around the proven principles of IBSE and based on materials that have already been tried and tested as part of the original Pupil Researcher Initiative (PRI) project.Chain Reaction will also establish a European teachers' network, aimed at providing support to teachers, sharing experiences and expertise between teachers and training experts. This will help develop the work of the project through delivery, and will also contribute to sustainability in the longer term. The network will aid dissemination of the project resources and outcomes, while enabling peer support both within each year of the project, and across the project as a whole.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interoperable solutions for implementing holistic FLEXIbility services in the distribution GRID' (FLEXIGRID), addressing dissemination and exploitation.

assistant: **Impact**

The expected increasing share of variable RES is challenging the electric grid in terms of reliability, stability and security of supply. Indeed, the European renewable target for 2030 (32% of total energy consumed) means that more than 50% of electricity will be generated from RES, most of which will be connected to the MV and LV grids. As an answer to these present and incoming challenges, FLEXIGRID project proposes to improve the distribution grid operation making it more flexible, reliable and cost-efficient, through the development of 4 HW and 4 SW solutions. Furthermore, a single open source platform will integrate the different solutions making them interoperable with the IT systems used by the energy stakeholders, increasing its replication potential. With the aim of increasing the project’s replication potential, 8 use cases have been identified to address EU most common distribution grid problems. These use cases are represented by 4 complementary demo-sites ready to upgrade FLEXIGRID solutions towards TRL8: a rural and peri-urban network in Spain with a RES share of 39%; a resort in the Greek Island of Thasos able to integrate 10% of RES; an urban grid in the city of Zagreb with congested areas, and an isolated valley in the South-Tyrol region of Italy with more than 50% of hydroelectric energy. To reach the project objectives, the consortium counts with partners representing all the energy system value-chain. In this sense, 2 RTOs and 2 Universities will work together with 5 technology providers to develop the project solutions and deploy them in the four demo-sites, represented by 3 DSOs and 2 large companies. Finally, 2 associations will ensure the exploitation and dissemination of the project results along the EU energy community. Finally, FLEXIGRID will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bridging Model Order reDuction with mAchine Learning in Vibro-Acoustics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Within the design and operational phase of mechanical structures it is difficult to reconcile high acoustic performance and a low ecological footprint. To mitigate noise impact, noise reduction strategies often lead to increased product mass and volume, exacerbating material consumption, thereby contradicting with the sustainability objectives of the EU. The concept of Digital Twins (DTs) can offer a great solution to this dilemma, optimizing simultaneously for both these opposing goals. Being a digital counterpart of a noise-emitting asset, DTs can predict its behavior under different scenarios and, by exploiting real-time data, they can make well-advised decisions for its design and maintenance.While existing DTs are either static when relying on physics-based models or lack physical interpretability with data-driven models, BiMODAL VA seeks to revolutionize this field, by bridging the best of both worlds. Namely, by smartly combining physics-based Reduced Order Models (ROMs) with machine learning based models, the primary objective of BiMODAL VA is to propose novel hybrid vibro-acoustic DTs, that will be simultaneously faster, more accurate, dynamically evolving and interpretable. Towards this objective the project is split into three science subobjectives that include i) the development of a data-driven correction methodology for vibro-acoustic ROMs based on the concept of closure modeling, ii) creating hybrid models for iterative designs, where physical prototypes data are not available for all iterations, and iii) developing dynamic ROMs to accommodate a potential change in physics (e.g. system degradation). The Experienced Researcher within BiMODAL VA will achieve these objectives by exploiting not only the strong transatlantic network on DT technologies, consist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Energy Solutions Optimized for Islands' in the context of a Horizon 2020 call.

assistant: **Objectives**

Funds are available to finance energy efficiency and renewable energy projects. Many islands are engaged in energy transition; however most of them haven’t the expertise to concretely launch investments, access finance and kick start the projects. NESOI aims at filling this gap through a hands-on approach allowing to get the expected financial leverage towards the effective implementation of islands’ energy transition plans. Starting with a broad survey gathering EU islands’ needs, NESOI provides a platform where islands can access both indirect and direct support: 1) Provided through a tailor-made digital platform, the indirect support consists in training material, best case examples, toolkit for technical and economic best practices and a cooperative space for islands, investors and technology developers; 2) Based on transparent technical, social, economic and environmental criteria, NESOI selects projects for customised direct support from consortium experts and from external ones for local aspects thanks to a cascade mechanism. NESOI supports projects at different stages of development, starting from early stage ones requiring a high-level technical & economic assistance, to more advanced ones asking for specific and detailed contributions on various fields (technical, legal, financial), putting forward a reality-check mindset, to make islands focus on solid projects with the potential to attract investors. NESOI implements capacity building and coaching activities to ensure raising awareness and capacity of public authorities' staff for developing investible projects with the aim to empower Local Communities in a success pursuit of the energy transition. Broad communication activities at EU level and links with other initiatives like BRIDGE and the Cities Facility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated Designs for Future Floating Offshore Wind Farm Technology' under Horizon Europe.

assistant: **Concept**

The importance of an increased exploitation of renewable energy sources is highlighted by the recent geo-political events with their impact on energy security and pricing, together with the global efforts to mitigate the anthropogenic climate change. Floating offshore wind, with its tremendous potential, will play an important role in the future to achieve the European Commission’s ambitious goals towards a climate-neutral energy transition. However, the required expansion of floating offshore wind capacity to achieve, e.g., the EU’s SET Plan targets, challenges the goal to protect and preserve bio-diversity (habitats and species) in the EU sea basins as set forth, e.g., by the Mission Healthy oceans. The INF4INiTY project (INtegrated designs for Future Floating oFFshore wINd farm TechnologY) aims to support the solution of this challenge. By developing critical technologies for the offshore wind farm of the future which enable balancing human needs (clean energy) with nature’s and society’s demands (decreased negative environmental and social impact). In particular, INF4INiTY provides two major technology innovations: an innovative nature inclusive design for gravity anchors and their associated scour protection system and (2) an innovative primary artificial reef structure combined with the floating structure of a floating offshore wind turbine. To that end, INF4INiTY combines world class numerical modelling and experimental analysis expertise with leading industrial technology development. Being immersed in a holistic techno-environomic, multi-level, multi-objective optimisation framework, INF4INiTY’s technology development results in truly innovative, economically viable, and sustainable solutions for the current techno-socio-enviro-economic challenges of the floati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Visual Translatomics – Deep ribosomal insights by cryo-electron microscopy of actively translating ribosomes' in the context of a Horizon Europe call.

assistant: **Objectives**

Structure determination of dynamic macromolecular molecular machines and elucidating their conformational landscapes are fundamental tasks of structural biology. The ribosome as a paradigmatic macromolecular machine interacts with numerous ligands and factors throughout its functional cycles, which in turn are driven and regulated by various conformational modes. Project DeepRibosome proposes a new way to perform structural studies. It is based on our recent finding that E. coli ex-vivo derived polysomes carrying the translatome can be efficiently reactivated in the PURE in vitro translation system. Cryo-EM of actively translating ribosomes results in comprehensive structural landscapes. During steady state, all intermediates are expected to be present, including the short-lived ones. Supported by preliminary data, we estimate that applying multi-particle sorting of images we can resolve states with a lifetime in the one-digit millisecond range. This allows us to study under optimal conditions fast steps such as the GTPase factor-dependent reactions or peptidyl-transfer/accommodation without artificially stalling the reaction by antibiotics or non-cleavable GTP analogues. The structural studies will be accompanied by functional assays including Ribo-seq to monitor translation of the cell-derived translatome in a cell-free system. While, we will also conduct in situ structural analysis for comparison, the strength of our new approach is that we can track translation from an integrated structural and functional perspective, preserving/reconstituting many native features but under defined and controllable conditions. This will not only provide insights into the molecular mechanism of translation at the next level of understanding but also allow us to answer long-standing q
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards Shared Accountability: Rethinking the Locus and Scale of Assessment and Improvement in Education' (ACCOUNTED).

assistant: **Innovation**

Accountability has emerged as a central feature of educational governance worldwide. However, the prevailing accountability approach in education, the so-called performance-based accountability (PBA), has led to adverse effects and discomfort among key stakeholders in the education sector. PBA, with its focus on individual schools as primary account providers, intensifies competitive pressures, fosters institutional fragmentation, and often stigmatizes disadvantaged schools. Recognizing these drawbacks, several governments are in the process of re-evaluating their accountability frameworks; this entails not only adjusting the measurement of performance outcomes but also giving greater attention to teaching-learning processes that were previously overlooked.Despite these efforts, ongoing reforms often overlook a crucial dimension: the scale at which accountability practices occur. ACCOUNTED asserts that optimizing accountability requires not only a shift in focus but also a change in the locus of account-giving practice: from individual schools to broader school networks. This recalibration of accountability, emphasizing shared responsibility among schools within a network, holds the key to fostering meaningful and cooperative relationships, initiating sustained improvement dynamics, and mobilizing additional educational resources at the local level. The effective implementation of this approach necessitates a meticulous policy design that organizes accountability relations and practices within the context of school networks. To bridge the gap between policy and practice, we propose testing and refining the 'shared accountability model' through a participatory design strategy involving real school actors. This innovative approach, by fostering collaboration and awareness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordinating Twinning partnerships towards more adaptive Governance in river basins' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Over the past years, the EU has funded several projects that undertook research on specific integrated water resources management (IWRM) issues in case studies carried out on twinned river basins from Europe and from developing countries. The aim of Twin2Go now is to review, assess, synthesize and consolidate the outcomes of these projects in order to make them transferable and applicable to other basins, and to disseminate the project results effectively to relevant authorities, stakeholders and end-users. This will contribute to the overall goal to underpin the implementation of IWRM in line with the targets of the EU Water Initiative.   In order to achieve this aim, Twin2Go will elaborate a methodology that allows comparative analysis and synthesis of the outcomes of the diverse projects. The consolidated outcomes will feed into best practice guidelines for the adoption and implementation of sustainable water resources management plans. To ensure up-take of the research results in water resources management practice and political decision making, all synthesis activities will involve stakeholders from the projects and basins and synthesis results will be effectively disseminated to all relevant levels of target groups including high level decision makers in water policy. In its effort, Twin2Go will focus its activities on the thematic priority ‘adaptive water governance in the context of climate change’ and cluster past and ongoing twinning projects along their target regions (Latin America, Africa, NIS, South and South East Asia).  Through its co-ordinating activities, Twin2Go will bring together participants and lead partners from past and ongoing projects as well as international water networks. This will allow increasing the output and benefit of ongoing research