RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of the Benefits of innovative Concepts of laminar nacelle and HTP installed on a business jet configuration' (BinCola).

assistant: **Concept**

The global target of the project “BinCola” is the experimental verification of benefits coming along with the replacement of classically designed nacelles and HTP by enhanced components specifically developed for natural laminar flow (NLF) development. To ensure a realistic evaluation and assessment of benefits relevant wind tunnel tests will be performed at flight Mach and Reynolds numbers.An existing basic model of a business jet configuration will be made available by the Topic Manager and serve as the reference configuration. He is also responsible for the provision of the laminar design of the components to be replaced while their detailed design, manufacturing and assembly are part of this proposal.Transition monitoring is generally performed at cryogenic conditions by using temperature sensitive paint (TSP). To visualize laminar and turbulent areas a positive or negative temperature step has to be performed in a wind tunnel violating by nature the consistency of all flow parameters. New developments at ETW and DLR offer to overcome this deficit by innovative surface heating concepts which are proposed here for application. This approach will make temperature steps superfluous; hence, allow taking images during continuous incidence polars, the standard testing sequence in ETW
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cold Electron chemical reactions and physical Interactions with Solids: fundamental experiments on damage and synthesis of biomolecules' (CERIS).

assistant: **Concept**

The proposed project involves the new field of the interaction of very low energy (cold") electrons with condensed molecules. The aim is to study (i) the breakdown of biomolecules, e.g. DNA (radiation damage) and (ii) biomolecule synthesis, e.g. aminoacids, in ices of e.g. water, ammonia, methanol etc. in the context of electron induced processing at the molecular level, relevant to DNA damage, nanoscience and astrobiology.The project will further our ability to manipulate and control physico-chemical processes at the molecular level and how to control electron interactions in a new energy regime. Electron-induced processes will be extended into unexplored fields for Framework 6 in biology and nanoscience ERAs: studies of biomolecule irradiation have only been reported down to electron impact energies of ~1eV. The project concentrates on the energy range down to a few meV, where cross-sections for attachment may be much larger and damage effects may be greatly enhanced.Using a synchrotron based cold electron source, DNA, oligonucleotides and their constituent molecules will be irradiated with electrons and the results analysed by gel electrophoresis and the novel technique of Atomic Force Microscopy, the latter to show conformational changes. Studies of the synthetic role of cold electrons arise from interest in the formation of biomolecules, e.g. aminoacids, around the early Sun and Earth and identified in meteorites.The results of this work have spin-off in nanofabrication in bio-nanotechnology. After two years, the expertise of the applicant in the techniques of the handling of biomaterials, in electron physics, in many related technical issues, will be greatly enhanced, leaving the applicant with excellent prospects for a future career in research. The new input tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissecting long non-coding RNA function using in vivo synthetic biology' in the context of a Horizon Europe call.

assistant: **Objectives**

Precise spatiotemporal regulation of gene expression is essential for healthy embryonic development. Long non-coding RNAs (lncRNAs) contribute to the regulation of gene expression. However, our current understanding of lncRNAs derives mostly from in vitro studies, with little known about their function in vivo. The core aim of this action is to dissect mechanisms of gene regulation by lncRNAs in vivo. The lncRNA Maenli is a perfect model to gain insight into lncRNA function as it activates a specific target gene in a tissue-specific manner during mouse embryonic development. This enables a quantitative in vivo read-out without compounding genome-wide effects. My hypothesis is that Maenli function is restricted to its 3D chromatin domain where it activates its target gene through transcription-associated processes, and not via the mature lncRNA transcript. To test this, I require methods that enable manipulation of the entire ~25kb locus and site-specific insertion in the genome. I will use cutting-edge synthetic biology to re-construct and manipulate Maenli, insert it in specific genomic regions, and examine its effect on target gene expression and phenotype in the mouse embryo. I will use low-input CUT&RUN to assess the functional chromatin state associated with Maenli. This interdisciplinary approach will go beyond the state of the art to illuminate specific mechanisms of cis-acting lncRNA function in vivo. This has not been possible until now due to technical limitations in conventional gene editing and challenges associated with studying lncRNAs in vivo. I anticipate that SynLncRNAs will set a new standard to study lncRNA function in vivo; impacting fundamental, disease and evolutionary research on gene regulation, as well as society and education. With expertise in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'FORENSIC METHYLATION ANALYSIS TOOLSETS (FORMAT)' (FORMAT) under Horizon Europe.

assistant: **Objectives**

The ForMAT project addresses limitations  in forensic DNA profiling, particularly in criminal cases, disaster victim identification (DVI), and legal age assessment for asylum claimants. Traditional DNA methods struggle with unsolved cases, mass disasters, and legal age estimation. ForMAT focuses on DNA methylation (DNAm) as a solution, using epigenetic markers to estimate age and lifestyles, as well to predict tissue type. This approach enhances criminal investigations by narrowing suspect profiles and expedites missing person identification in mass disasters, improving the return of remains to families. In asylum cases, DNAm offers a radiation-free alternative for assessing age, reducing reliance on X-rays.ForMAT builds on the VISAGE project, aiming to advance these tools from Technology Readiness Level (TRL) 5 to TRL 7. By developing new DNAm kits and a bioinformatic applicaiton including forensic prediction models, ForMAT enables law enforcement to estimate age, to infer lifestyles and to identify the tissue-of origin from DNA samples. Kits include a DNAm somatic kit, as well as a DNAm germ-line kit for criminal cases, a DNAm DVI kit for guiding in the identification process of human remains, and a DNAm legal age kit for asylum assessments. The integration of Next Generation Sequencing (NGS) technologies, including second- and third-generation sequencing, enhances forensic workflows and ensures high accuracy even with degraded samples.The ForMAT consortium , consisting of 11 EU institutions, leverages expertise across countries and disciplines to bring these innovations to real-world use. Members include leading universities, police bodies, and forensic institutes, committed to scaling up, testing, and validating these tools across Europe. Their involvement in intern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Role of Autophagy in Synaptic Plasticity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neuronal metabolism is emerging as an essential regulator of brain function and its deregulation is a common denominator in neurological disorders entailing intellectual disability and synapse dys-morphogenesis.  The autophagy-lysosome system is the major catabolic pathway dedicated to the recycling not only of protein aggregates but also lipids, nucleic acids, polysaccharides and defective or superfluous organelles, among others.   Appreciation of the role of autophagic pathways in the healthy and diseased brain continues to expand, as accumulating evidence indicates that proper regulation of autophagy is indispensable for neuronal integrity.  At the cellular level, several lines of evidence implicate autophagy in the regulation of synaptic plasticity. However, the synapse-specific substrates of autophagy remain elusive.  Similarly, the synaptic defects arising from autophagy impairment have never been thus far systematically addressed, yet they translate into severe behavioural deficiencies, such as compromised memory and cognition, pertinent to disorders of intellectual disability. The present proposal aims to determine how autophagy regulates synaptic plasticity and how its deregulation contributes to synaptic defects.  In particular, the objectives aim to: 1) Monitor and characterize the presence of the autophagic machinery in pre- and post-synaptic sites.  2) Identify autophagic substrates residing in synapses and whose turnover via autophagy determines synaptic plasticity.  3) Characterize the synaptic defects and ensuing behavioural deficits arising from impaired autophagy in the hippocampus. 4) Use C. elegans as a model system to address the evolutionary conservation of the synaptic role of autophagy and perform forward genetic screens to reveal novel regulator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'WILD HOPPER - Heavy-Duty UAV for day and night firefighting operations' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

DRONE HOPPER is a company devoted to designing and manufacturing heavy-duty multirotor drones. For that, it hasdeveloped a number of proprietary technologies aimed at, essentially, providing a safe and reliable heavy-lifting platform.Special care has been taken on liquid transportation and release.WILD HOPPER is a 600-litre platform designed for forest fire firefighting. This payload capacity overcomes typical limitationsof electrically powered drones that cannot be used for anything more than fire monitoring, as they do not have sufficientlifting power. It uses all the technologies developed by DRONE HOPPER, yielding a novel tool to counter rush firesworldwide.The enhanced capabilities of the WILD HOPPER allows to complement existing aerial means and overcome their mainlimitations, especially the need to cover night operations. This allows reducing heavily the duration of the wild fires byallowing continuous aerial support to the extinguishing activities once the conventional aerial means (hydroplanes andhelicopters) are set back to the base at night.Other advantages of the WILD HOPPER are the precision of the release, derived from multirotor platform dynamiccapabilities. This, together with the proprietary water jet nebulization system, yields a very high efficiency compared totraditional means that carry similar (helicopters) or more liters (hydroplanes) that just drop the water at a certain speed ahighest altitudes over the target fire, limited by their dynamic operational envelope.Being an autonomous vehicle, WILD HOPPER does not put at risk human lives as platform management is done on a safeground base.The WILD HOPPER is a less expensive platform than conventional aerial means, allowing small and medium regionalbodies to own their own fast-response resources. Bei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular mechanisms of glioma genesis' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Glioma is the most common tumour of the brain and its most malignant form, glioblastoma multiforme, is virtually not curable. Very little is known about gliomagenesis and progression at the molecular level and not much progress have been achieved in the discovery of new therapies during the last years. Among others, two signalling pathways are very relevant in glioma, the TGFb pathway and the PDGF pathway. TGFb has two differentiated faces in glioma progression. In low-grade glioma, TGFb is an anti-tumorigen ic factor that mediates the inhibition of proliferation. In high-grade glioma, glioblastoma multiforme, TGFb becomes an oncogenic factor that induces proliferation, invasion, angiogenesis and immuno-supression.Another pathway that is important in the genes is of glioma is the PDGF pathway. PDGF and the PDGF receptor are highly expressed in human glioma and PDGF over-expression promotes the formation of glioma in a mouse model. Our preliminary data indicate that at the crossroad of the PDGF and TGFb pathways there is a transcription factor called FoxG1. FoxG1 is the cellular homologue of an avian sarcoma viral oncogene called Qin. FoxG1 is expressed in neuroprogenitors and glioma but not in differentiated cells. FoxG1 inhibits differentiation and promotes proliferation.We hypothesize that FoxG1 promotes the switch of the TGFb action towards its malignant effects and in part mediates PDGF oncogenesis. In order to test this hypothesis we will undertake three approaches: we will study TGFb,PDGF and FoxG1 molecular interactions in a cell culture model using human glioblastoma cell lines. We will assess their role in glioma progression in a mouse glioma model. And, we will support our findings analysing human tumours from the Vall dHebron Hospital tumour bank. This projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Influence of Brain-Stomach Interactions on Hunger, Satiety and Brain Function' (BRAINSTOM), addressing dissemination and exploitation.

assistant: **Impact**

Hunger, satiety and feeding are complex phenomena exerting a profound influence on health and wellbeing. Hunger, or the mental urge to eat, is often associated with the feeling of an empty stomach. Satiety refers to a cascade of physiological, neural and metabolic mechanisms that inhibit further eating. Importantly, the decision making process in the brain that determines what, when and how much we eat is modulated by subconscious signals from the gut that can activate the brain’s dopaminergic system and reinforce dietary habits, explaining why so many people struggle to make healthy food choices and why the prevalence of obesity in developed countries is so high. Scientific knowledge on the brain-gut mechanisms behind hunger and satiety is incomplete, limiting our ability to develop efficient therapies and public policies targeting obesity and overweight. In BRAINSTOM, I have designed an innovative research program to study how the brain’s signatures of hunger and satiety are linked to the movements and contractions of the stomach, combining  my previous expertise in the simultaneous recording of the stomach and functional magnetic resonance imaging in humans with research methods from nutrition and metabolism and recent advances in positron emission tomography of the dopaminergic system. The three key hypotheses of my research proposal are that i) hunger feelings are associated with measurable changes in movements and contractions of the stomach ii) as food transits through the stomach, the brain releases dopamine and satiety feelings arise iii) the electrical activity of the stomach interacts with cortical, subcortical and neuromodulatory brain structures, influencing brain activity, interoception and cognitive functions beyond feeding. These findings will inform nov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An authoring environment for adaptive multimedia documents' (CHAMELEON).

assistant: **Innovation**

The purpose of the project is to define and implement a support tool for multimedia authoring and presentation in the context of professional publishing, cultural heritage, tourism and computer-based training. The prime objectives are to define and implement an industrial prototype of a multimedia authoring tool which provides support for the production of durable multimedia documents and which supports the notions of detail-based, content-based, quality-based, resource-based and format-based projections of a single meta-document.The tool will be a development of an existing research prototype which will be ported to a mass market operating system environment and which will be expanded to meet the needs of the target industries. Some of the additional functions to be developed were identified before the start of the project and others will be defined during the course of the project. This will be done in two ways: through a series of trials by users who will be selected to be representative of the target markets, and through market watch activities. The existing research prototype will form the basis for developing the additional functionality which is aimed for and then the functions will be ported to the industrial prototype.The major result of the project is intended to be the industrial prototype. This will be a prototype of an authoring and presentation tool which allows hypermedia documents to be created by content owners and presented on low-cost end-user platforms. This end-product will allow scaleable, network-based access to multimedia data on a variety of end-user platforms. This end-product will be exploited directly and in conjunction with consultancy services based on the know-how gained during the project.Secondary results of the project are planned to be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TREASURES: Digging into dwarf galaxies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Milky Way is an environment rich with satellite galaxies, stellar streams and accreted systems. Encoded in these structures is the formation and evolution of the Galaxy through cosmic time. Fortunately, these nearby relics can be studied in extraordinary detail – star by star – revealing the properties of the first stars, the build-up of chemical elements in the Universe, the nature of dark matter, and hierarchical galaxy formation.To unlock these treasure troves of hidden information, I designed a large-scale survey: 4DWARFS (PI: Skúladóttir, 520,000 fibre hours) that after a very competitive 2-year selection has now been accepted as a 5-year 4MOST survey, starting in 2024. 4DWARFS will collect high-quality spectra of individual stars in close to 50 dwarf galaxies, and dozens of stellar streams from systems currently undergoing disruption.The goal of TREASURES is to execute and exploit this large 4DWARFS survey to its highest scientific potential. TREASURES will provide the community with stellar ages, radial velocities and chemical abundances for over 130,000 stars, and thus increase the number of stars with detailed abundance information in dwarf galaxies and streams by several orders of magnitude, ensuring the far-reaching impact of this project. Furthermore, TREASURES will use state-of-the-art models to contrast these new large data against theory, and put in context with the Milky Way.  Through an ambitious combination of modelling and data of unprecedented magnitude and completeness TREASURES will quantify and put fundamental constraints on:(I) The properties of the first stars (mass and energy distributions)(II) The origin of the chemical elements (physics of stars, supernovae and neutron star mergers)(III) Hierarchical galaxy formation at the smallest mass