RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unveiling the population of supermassive black hole binaries near merger' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

At the center of nearly every galaxy in the Universe lurks a supermassive black hole with mass millions to billions that of the Sun. When two galaxies collide,  their supermassive black holes sink to the center of the newly forming galaxy. There in this nascent galactic nucleus a supermassive black hole binary is formed. Supermassive binaries are the subject of a long standing mystery in astrophysics: will these monstrous black holes merge and what can that tell us about the extreme environments that shape them? I will make great strides towards solving this mystery through advancing the state of the art in simulations of interactions of supermassive black hole binaries and their gaseous environments. From these simulations I will predict binary orbital evolution rates as well as observational signatures of the interaction. I will use the former to build the most accurate binary population models to date and the latter to constrain these models via observational searches in the newest time domain data, possibly leading to the  first detections of these elusive black hole pairs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Production of Sustainable Diesel-Miscible-Biofuels from the Residues and Wastes of Europe and Latin America' (DIBANET), addressing dissemination and exploitation.

assistant: **Impact**

The increasing reliance on imported diesel fuels, in addition to annual increases in the quantities of organic wastes are threats to the EU and Latin America. This project (DIBANET) will combat these threats and help to eliminate diesel imports by developing novel technologies that will allow the sustainable production of diesel miscible biofuels from wastes. It will build on the key, complementary, strengths of researchers and industries of both regions to advance this field. This enhancement of co-operation will ensure that the whole process, from feedstock to process residues, is engineered for maximum efficiency. The links between regions will be further enhanced by the establishment of inter-regional student scholarships; 2 large brokerage events to engage all stakeholders; and a summer school for knowledge transfer. DIBANET will increase the yield from biomass, beyond the current art, of levulinic acid, a valuable platform chemical that can be combined with ethanol to make a diesel fuel. Processes will be advanced to utilise the solid residue that remains after the acid-treatment. From this residue treatment process a bio-oil and biochar will result. The bio-oil will be upgraded to produce a diesel miscible biofuel. The biochar will be examined for use as a soil amender for enhanced biomass yields. Advanced analytical techniques to benefit levulinic acid yields will be developed and employed online to allow real-time adjustment of biomass conversion conditions. All of the fuels produced will be tested to ensure compliance with current fuel requirements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Novel genechip technology for simplified detection of molecularly heterogeneous genetic diseases: detection of cystic fibrosis as a model'.

assistant: **Objectives**

The objective is to develop and demonstrate a new gene array technology platform for high-throughput diagnosis of CF and CF-related diseases as a model for other genetic diseases. An integrated magnetic sensor-based gene array will be developed comprising novel giant magneto resistance or tunnel magneto resistance sensors for direct magnetic detection of hybridisation of target DNA-tagged magnetic beads. New CF diagnostic assays will be developed based on oligonucleotide or based-based magnetic sensor array detection of qualitative or quantitative changes in RNA products resulting from either mutations in the CFTR gene (splice site mutations) or possible atypical RNA expression patterns from other genes caused by the presence of an abnormal CFTR gene. Screens for known mutations in the CFTR gene caused by Snips in genomic DNA samples from blood using a novel primer-extension based micro array method will also be developed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced ultra-thin ceramic membranes for efficient industrial processes' to be submitted under Fifth Framework.

assistant: **Abstract**

The proposal aims in development of ultra thin dense ceramic membranes possessing simultaneously high separation selectivity and permeability at T < 900°C to be applied to industrially important topics, i.e. high purity 02 production from air, selective catalytic oxidation and CO oxidation in automotive fuel cell environment. Innovative techniques as MOCVD and Sol-Gel will be used which have already shown to function in small scale. New industry fields for and application of dense membranes are envisaged which will be accompanied with employment creation. The new technique will allow cleaner, eco-efficient processes with reduction of energy costs (e.g. <70 % for pure 02 production), less waste production (e.g. no extra NOx in combustion using pure oxygen instead of air) and supporting European competitiveness (e.g. leadership in fuel car development).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'URBAN TRANSPORT OPTIONS FOR PROPULSION SYSTEMS AND INSTRUMENTS FOR ANALYSIS' in the context of a Fourth Framework call.

assistant: **Objectives**

The main objective is to provide decision-makers with the necessary information base, tools, methods and guidelines for hastening the market introduction of the most appropriate transport solutions based on new propulsion technologies and systems (NPS).NPS will have a wide range of impacts on many aspects of society, in particular on environment, which need to be understood by decision-makers, together with how these impacts affect the likelihood of market take-up. UTOPIA will draw on experiences and previous studies in Europe and the rest of the world, to assess the introductory methods that have been used. The project will analyse how these can best be applied to the specific situations that occur in Europe and provide tools to understand what the effects of this might be. Ongoing demonstration projects such as ZEUS and CENTAUR will be used as case studies and test sites. This will allow the tools and methods developed in UTOPIA to be tested and honed during the project.The project will:- analyse the methods and results of new propulsion system demonstration projects around the world;- develop guidelines on the best ways of introducing such systems based on the findings of this analysis;- develop software to help decision-makers in both comparative testing of different sites where new systems are being introduced, and in finding appropriate technological solutions for specific urban situations. %- State-of-the-art reviews, inventories and databases of new propulsion systems and market-oriented transport concepts based on these systems, recommendations on policy guidelines for fostering the Europe-wide introduction of new systems.- A best practi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Precision Cosmological Parameters' (CosmoPars) targeting Seventh Framework.

assistant: **Abstract**

Proposal summary (half page, possibly copy/paste abstract from the administrative form A1)Observations of the Cosmic Microwave Background (CMB) allow us to see 98% of the way to the big bang, back to a time when the Universe was only a few hundred thousand years old. Other forthcoming data will probe the more local universe in great detail. To test different possible universe models we need accurate theoretical predictions for this data in each model, and new sampling methods to solve the inference problem.CMB data is most powerful if combined with information from other sources, allowing us to test many possible models of the universes and constrain cosmological parameters. As more models and parameters can be constrained, and higher precision means that more small uncertain corrections need to be consistently modelled, the problem of inference becomes challenging. I propose to develop ground-breaking new sampling methods for testing models with many parameters. To do this I will find novel sampling techniques, make efficient use of qualitatively different properties of different parameters, and develop a new parallelized sampling code that can be run on-demand in the cloud, leveraging the power of potentially vast and cheap cloud computing facilities and freeing up dedicated supercomputers for the problems where they are really needed.In addition my team will develop new accurate theoretical predictions for confrontation with data, including analysis of new non-linear processes that will be a major source of confusion for dark energy and early universe studies, as well as correlations between different data sets.I am applying for 70% of my time and two ERC postdocs to tackle these challenges.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Thematic network on combined heat and power (CHAPNET)'.

assistant: **Objectives**

The development of Combined Heat & Power is a crucial technology for the energy sector. This TN will advance excellence in CHP, ensuring EU global leadership in its research, development & application. The network will focus on key clusters for medium to long term RTD, thus maximising the benefits to the Community. These clusters and other work packages will include micro-CHP, trigeneration, gas engine applications, optirnisation of CHP components, pre-normative research, education & training & the needs of Accession Countries. The consortium brings together innovation, global reach, effective networking & leaders from industry & academia. The challenge for the TN is to develop a critical mass of expertise for CHP that will provide the tools necessary to ensure CHP meets the expectations in terms of environmental improvement, competitiveness & security of energy supply. The network will be a catalyst for CHP RTD in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

T cell non-Hodgkin lymphomas (T-NHLs) are highly aggressive malignancies that are largely resistant to conventional therapies. T-NHLs remain significantly understudied, and their molecular pathogenesis is still not well defined. Comprehensive analysis of mature T-cell lymphomas has identified multiple gain-of-function mutations in T-cell receptor (TCR) signaling molecules as an overarching hallmark of T-NHL sub-entities. Under physiological conditions, these molecules control the expansion, survival and effector function of antigen sensing T cells for host defense. Presumably, the oncogenic TCR signaling variants in lymphoma enforce these TCR programs in a constitutive manner and thereby drive continuous proliferation and expansion of the malignant clone. However, experimental in vivo evidence for this hypothesis is still limited, and the negative regulatory tumor suppressor mechanisms that can counteract oncogenic T cell signaling remain largely undefined. We recently identified the inhibitory immune receptor PD-1 as a key haploinsufficient tumor suppressor in T-cell lymphoma that is inactivated in up to 30% of human cases. The overall goal of this proposal is to comprehensively model and dissect T-cell lymphomagenesis driven by oncogenically enforced T-cell receptor pathways and to identify the PD-1 dependent and independent tumor suppressor mechanisms that inhibit these events. We will additionally explore the functions of new negative regulators within the PD-1 pathway or related pathways in antigen-mediated T cell activation. We expect that our results will provide fundamental new insights into the molecular pathomechanisms of highly aggressive T cell cancers and additionally lead to the identification of new negative regulators of antigen-mediated T cell activatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissecting the signalling cascade in the vertebrate spindle assembly checkpoint' (KINETOCHECK) under Sixth Framework.

assistant: **Objectives**

The mitotic checkpoint acts to inhibit entry into anaphase until all chromosomes havesuccessfully attached to spindle microtubules. Unattached kinetochores are believed to release inactivated form of proteins such as BubR1 and Mad2 that inhibits APC/C-dependent ubiquitinylation and subsequent proteolysis of components needed for anaphase onset.Previous work by Dr. Abrieu(the host laboratory) has shown that the kinase Mps1 is required to recruit some checkpoint components onto the kinetochore, including CENP-E, a kinesin-like protein acting as a sensor of kinetochore to microtubules attachment. My work in this lab will consist on further dissecting the regulation of CENP-E by Mps1 in this context, using biochemical, chimiogenetic and microspectroscopic approaches. This will involve developing a new method to identify Mps1substrates; a multidisciplinary approach (chimiogenetic) in tight collaboration with the organic chemistry laboratory of Prof. Perigaud. I am also proposing to identify the minimal kinetochore binding domain of CENP-E. This will allow me to follow its activation, and regulation of the downstream kinaseBubR1 at the kinetochore by FRET (Fluorescence Resonance Energy Transfer). Finally, I will try to uncover new kinetochore proteins by fishing for binding partners of two outermost kinetochore components (CENP-E and Mps1) and the innermost centromeric protein (CENP-A). Altogether, this proposal should provide a better understanding of the checkpoint regulation at the kinetochore, a process whose deregulation is leading to aneuploidy, a hallmark of cancer.Hopefully, these studies could lead to new therapeutic development specifically targeting cancer cells by directly activating checkpoint regulators, thus preventing side effects onto normal cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enabling autonomy, participation, and well-being in old age: the home environment as a determinant for healthy ageing (ENABLE-AGE)' (ENABLE-AGE), addressing dissemination and exploitation.

assistant: **Impact**

This interdisciplinary project will consider subjective and objective person-environment relationships as important determinants to healthy ageing, in a EU perspective. The main aim is to examine the home environment as a determinant for autonomy, participation, and well being in old age, in a longitudinal perspective. The seven project objectives focus person-environment transactions among very old adults in five different countries. A macro level update on housing policies will be performed, and integrated with the knowledge generated by a survey (N=2000) and an in-depth study (N=200), a revised and optimised standard methodology for housing issues as related to functional health will be provided, furthering the provision of evidence-based policy recommendations in order to maintain autonomy, participation, and well-being in old adults in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Illiberal Administrative Behaviour: exploring the implementation of illiberal policies and strategies for prevention' (ILLADMIN).

assistant: **Concept**

Democracy is at risk, also from the inside. Today, some civil servants are mandated to implement illiberal policies, defined as those including anti-plural (discouraging dissent and promoting homogeneity) or anti-institutional values (rejecting separation or supervision of power). Civil servants who oppose these policies face severe criticism and replacement. Conversely, others may behave illiberally and comply with the implementation request. Since public bureaucracy is essential for effective governance, the question of whether civil servants will implement illiberal policies, thereby displaying illiberal administrative behaviour, arises. Yet, it is surprising how little we know about this behaviour, why it occurs, and how it can be prevented.To investigate these questions this project: (1) defines and elaborates a conceptual map of illiberal administrative behaviour, and empirically examines civil servants’ positions on it; (2) identifies the determinants of illiberal administrative behaviour; (3) examines how civil servants can align with liberal democratic values to reduce their likelihood of implementing illiberal policies. The empirical analysis focuses on 10 countries from 5 administrative traditions and implements an integrative multi-method approach combining panel surveys with different measurement strategies and experiments.The project breaks new ground in the study of illiberalism in public administration and offers fresh insights on the current crisis of liberal democracy. Theoretically, it conceptualizes illiberal administrative behaviour, elucidating the conceptual underpinnings of this phenomenon. Empirically, it develops measurement tools for assessing illiberal administrative behaviour among civil servants, examines its primary determinants, and explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting chromatin in cancer: histone deacetylases and differentiation therapy of acute myeloid leukemias (CHROMATIN AND CANCER)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Acetylation/deacetylation by histone acetylases (HAT) and deacetylases (HDAC) regulates gene transcription and specific functions, such as tumour suppression by p53. Abnormalities of HAT or HDAC are frequently found in tumours. Targeting of HDAC by small compounds is effective in the differentiation treatment of a small subset of leukaemia. We aim to determine whether HDACs are suitable general targets for cancer drug discovery. We will characterize the mechanisms of activities of HDAC/HAT in normal and cancer cells, and screen tumours with a panel of HDAC inhibitors. Our experimental approaches range from biochemistry, to molecular biology, to post-genomics (proteomics and nanotechnology), and include the functional validation of compounds and demonstrated mechanisms in animal model systems and tumour samples. Final objective is the design of differentiation treatment protocols for leukaemia and myelodysplastic syndromes.