RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Emerging technologies for crystal-based gamma-ray light sources'.

assistant: **Concept**

TECHNO-CLS project at the breakthrough in technologies needed for designing and practical realisation of novel gamma-ray Light Sources (LS) operating at photon energies from ~100 keV up to GeV range that can be constructed through exposure of oriented crystals (linear, bent and periodically bent) to the beams of ultrarelativistic charged particles. The TECHNO-CLS high-risk/high-gain science-towards-technology breakthrough research programme will address the physics of the processes accompanying the oriented crystal exposure to irradiation by the high-energy electron and positron beams at the atomistic level of detail needed for the realisation of the TECHNO-CLS goals. A broad interdisciplinary, international collaboration has been created previously in the frame of FP7 and H2020 projects, which performed initial experimental tests to demonstrate the crystalline undulator (CU) idea, production and characterisation of periodically bent crystals and the related theory. TECHNO-CLS aims to build the high-risk/high-gain science-towards-technology breakthrough research programme on these successful studies aiming at a practical realisation of the novel gamma-ray LSs such as CUs, crystalline synchrotron radiation emitters, and many others. Additionally, by means of a pre-bunched beam a CU LS has a potential to generate coherent superrradiant radiation with wavelengths orders of magnitudes less than 1 Angstrom, i.e. within the range that cannot be reached in existing LSs based on magnetic undulators. Such LSs will have many applications in the basic sciences including nuclear and solid-state physics and the life sciences. Theoretical, computational, experimental and technological results obtained in the course of this project will pave a way for key technological developments of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The economics of lasting peace: The role of policies and institutions'.

assistant: **Objectives**

This project aims to study what key institutions and policies are best suited to reduce incentives for engaging in appropriation and armed conflict. For achieving and sustaining peace it is crucial to get the incentives right of all main actors in society. While subproject 1 focuses on short-run policies to stop the fighting by drying out the funding of rebel groups and hence move from war to peace, all the remaining subprojects take a medium- to long-run perspective. Subprojects 2 and 3 focus on the medium-run and assess what mix of policies can help to bridge the short- with the long-run and consolidate peace. In particular, drawing on very fine-grained data from Northern Ireland I will in subproject 2 assess the role and interplay of factors of escalation / containment of violence (“Orange marches”, “peace walls”) and factors driving democratic representation (gerrymandering and power-sharing). In subproject 3 I will perform a network and conflict analysis based on Twitter data for the Arab Spring to assess the role of civil liberties and freedom of speech in consolidating peace. Subprojects 4 to 6 study factors that are crucial for sustaining long-run peace. In subproject 4 I will build a model of how the main political institutions affect the incentives for contesting democracy on the battlefield, focusing on the role of electoral systems, coalition governments, federalism and direct democracy. Subproject 5 studies the role of education for sustaining peace. With the help of a game-theoretic model I will study the various channels through which education affects incentives for conflict, before testing the main predictions empirically. Subproject 6 focuses on another key role of modern states: Health policies. After building a theory of how health affects combat inc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Euro Summer School on Photosensitivity in Optical Waveguides and Glasses' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This summer school deals with the subject of the interaction of the UV light with disordered matter especially silica based materials. These glasses are used for the elaboration of optical fibres, integrated optics or discrete optical devices such as lenses or mirrors. These are of great interest for telecommunication, especially for Wavelenght Division Multiplexing (WDM) optical transmission. From a scientific point of view, this school is centred on the understanding, of the mechanisms involved in index variation and of optical non-linear properties induced by UV irradiation. Several disciplines are involved in this field: chemists, physicists, engineers. Applications are in the field of new system of information in which the demand of engineers are high at the moment.The problem of UV interaction with the silica based glasses is very complex: - The first step of the process is an absorption. But, we begin just at this date after 40 years of research to understand few structure defects. The last results will be discussed at this meeting especially the one from young researchers; - Then, the above excitation dumps following several channels: luminescence, bond breaking and ion migration or electron migration, our knowledge on that point is still very weak. So, we do not know in which direction it is useful to search for increasing the photosensitivity. - Now, following the physical transformation, secondary processes can occurs which also leads to change of index. For the designer of optical devices this is very important. These are examples of problems on which we will make a step forward: - the UV active defects of the silica based materials - the mechanisms of UV induced transformation - the calculation of UV induced birefringence in the wave-guides. This summer sch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'As simple as possible: a modelling approach to upscale the relevance of ecotoxicological studies' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

As simple as possible: a modelling approach to upscale the relevance of ecotoxicological studies.A big discrepancy exists between the increasing demand for ecological realism in regulatory risk assessment and the effective implementation of ecotoxicological studies aimed at assessing the adverse effect of stressors at the population or higher level. The effect of toxicants is commonly measured on individuals as a proxy for the effect on populations but the actual population level impacts are very hard to determine. Ecological modelling can overcome this challenge. However, until now the complexity in the application of these models has presented a serious hurdle for their use in ecotoxicology.In this study we propose the application of a simple generic toxicokinetic-toxicodynamic model that integrates life-history traits such as growth, reproduction, maintenance and survival in one model organism to assess adverse effects of three different metals over time. We will carry out experiments to calibrate and test the model. The calibration of the model will allow the identification of the physiological modes of action of each metal, unraveling the different ways the chemicals can affect the life-cycle of the organism. We will improve the predictive and diagnostic power of these models by direct measurements of the time course of internal metal concentrations which will replace the currently used “scaled internal concentrations”, a very indirect approximation. Finally, we will couple the toxicokinetic-toxicodynamic model with an individual-based population model and explore the population level consequences of metal contamination.This research will provide insight into the physiological modes of action of three metals at individual level and their population level consequenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Inclusive Education and Social Support to Tackle Inequalities in Society' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ISOTIS addresses the nature, causes and impact of early emerging social and educational inequalities in the context of socioeconomic, cultural and institutional processes. The aim is to contribute to effective policy and practice development to combat inequalities. Quasi-panels and pooled longitudinal datasets will be used to examine the variation in early educational gaps and developmental trajectories across countries, systems and time. To disentangle the complex interactions between characteristics of systems and target groups, ISOTIS will study significant immigrant, indigenous ethnic-cultural and low-income native groups, associated with persistent educational disadvantages. ISOTIS will examine current resources, experiences, aspirations, needs and well-being of children and parents in these groups in the context of acculturation and integration, and in relation to local and national policies. ISOTIS aims to contribute to effective policy and practice development by generating recommendations and concrete tools for (1) supporting disadvantaged families and communities in using their own cultural and linguistic resources to create safe and stimulating home environments for their children; for (2) creating effective and inclusive pedagogies in early childhood education and care centres and primary schools; for (3) professionalization of staff, centres and schools to improve quality and inclusiveness; for (4) establishing inter-agency coordination of support services to children and families; and for (5) developing policies to combat educational inequalities. ISOTIS will develop inter-linked programmes for parents, classrooms and professionals using Virtual Learning Environments for working in linguistically diverse contexts. All this work together is expected to supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Signatures of cosmic rays and new fundamental particles in the Very high energy sky' (VerSi), addressing dissemination and exploitation.

assistant: **Impact**

Are there new fundamental particles and interactions Beyond the Standard Model of particle physics (BSM)?The most fascinating open questions in our current understanding of Nature support a positive answer. For example, the dark matter in our universe could be explained by new fundamental particles weakly coupled to the SM. Similarly, the unexplained Charge-Parity symmetry violation in strong interactions can be solved by introducing a new light particle, the axion. Some recent, intriguing anomalies in cosmic radiation have thrilled the community as potential evidence for new physics BSM.My project will shed new light on them by exploiting forthcoming observations of the very high energy sky with innovative techniques.   A long-standing excess of gamma-rays at GeV energies is measured towards the Galactic Center (GCE), and could be the very first signature of particle dark matter in our Galaxy. Cosmic ray accelerators could also explain the signal, but numerous modeling uncertainties prevent to firmly assess their contribution to the excess. I will use gamma rays at TeV energies to robustly characterise the TeV halos of cosmic ray accelerators and their contribution to the GCE, thus closing on the dark matter properties compatible with it.Besides, these sources will serve as an unique laboratory to constrain cosmic ray acceleration and propagation in the interstellar medium. This work will be instrumental to deeply investigate a new, promising signatures of photon-axion interactions, that is the modulation of the gamma-ray spectrum of Galactic cosmic ray accelerators. By exploiting the unprecedented energy resolution of forthcoming gamma-ray data at very high energy, I will search for axion-like-particle signatures in a yet unexplored parameter space. At LAPTh I will ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Propagation of atmospheric ROssby waves - connection to prEdictability of Climate exTremes'.

assistant: **Innovation**

Extreme weather events, such as heatwaves, droughts and flooding, have a devastating impact on humanity, causing increased mortality and suffering, as well as economic losses. Skillful predictions of such events, with sufficient lead-time for adaptation procedures can provide huge benefits to humankind. Recent extreme events, including the severe European and Russian heatwaves, have been found to be associated with particular atmospheric wave dynamics, specifically the propagation of Rossby waves along atmospheric waveguides. Our proposed research will explore the seasonal predictability of extreme events through a lens of atmospheric waveguides and Rossby wave propagation. We will answer four key research questions: I. What is the predictability of dominant modes of variability in waveguide geometry? II. How does the frequency of extreme events as a function of location relate to waveguide geometry in both observations and forecast systems?III. How do the results from I and II combine to provide predictability on the likelihood of extreme events? IV. How does model resolution impact Rossby wave propagation and the relationship to extreme events?Both re-analysis (observational) data, and seasonal forecast model data will be used. We will calculate the Rossby refractive index and analyze its spatial and temporal variability, quantifying the predictability in waveguide geometry. Extreme events (heatwaves, cold snaps, droughts and blocking events) will be identified in the datasets, with lag-lead regression and composites revealing the connections to the waveguide geometry. We will create empirical models to predict the frequency of extreme events, evaluate their reliability, and compare to these to existing dynamical forecasts. Our goal is to harness the increased underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Advancing cancer immunotherapy using natural killer cells for hematological and metastatic cancers'.

assistant: **Concept**

The development of monoclonal antibodies (mAb) to target tumor cells has tremendously improve cancer immunotherapy and benefit the treatment of aggressive cancer such as some types of lymphomas, leukemias, multiple myeloma and metastatic cancers. One of the mechanisms of action is the induction of antibody-dependent cellular cytotoxicty (ADCC) through the activation of CD16 on NK cells after binding to the Fc portion of Ab-coated tumor cells. Therefore, strategies that combine NK cell activation and mAb therapy has been intensively explored. However, tumor heterogeneity and unstable expression of the targeted molecule in the tumor cells limits ADCC for mAb therapy resulting in cancer relapse. Furthermore, intrinsic NK immunregulatory mechanisms as well as NK-specific tumor evasion mechanisms have also negatively impacted the use of NK cell-based therapies. In this proposal we will explore the mechanisms involved in the reduced NK cell function (NCF) observed after ADCC and/or NK cell activation (NCA) in order to develop novel strategies to achieve a sustained and stronger NCF by combining stimulating signals with suppression of inhibitory signals such as costimulation via CD137 and IL12, or SHP1/2 blockade. We hypothesize that the adoptive transfer (AT) of NK cells expanded by this novel method will result in better anti-tumor responses after mAb therapy even in tumor cells that express limited amount of the target molecule and limiting consequently cancer relapse rates. Furthermore, due to the overall improvement on NCF, we expect that the combination of AT NK cells with hematopoietic stem cell transplantation (HSCT) will also increase anti-tumor responses; which efficacy up to date has shown to be rather limited. Given the versatility of our approach, this therapy can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Advanced coupling of low order combustor simulations with thermoacoustic modelling and controller design'.

assistant: **Objectives**

Combustion is essential to the world’s energy generation and transport needs, and will remain so for the foreseeable future. Mitigating its impact on the climate and human health, by reducing its associated emissions, is thus a priority. One significant challenge for gas-turbine combustion is combustion instability, which is currently inhibiting reductions in NOx emissions (these damage human health via a deterioration in air quality). Combustion instability is caused by a two-way coupling between unsteady combustion and acoustic waves - the large pressure oscillations that result can cause substantial mechanical damage. Currently, the lack of fast, accurate modelling tools for combustion instability, and the lack of reliable ways of suppressing it are severely hindering reductions in NOx emissions.This proposal aims to make step improvements in both fast, accurate modelling of combustion instability, and in developing reliable active control strategies for its suppression. It will achieve this by coupling low order combustor models (these are fast, simplified models for simulating combustion instability) with advances in analytical modelling, CFD simulation, reduced order modelling and control theory tools. In particular:*  important advances in accurately incorporating the effect of entropy waves (temperature variations resulting from unsteady combustion) and non-linear flame models will be made;*  new active control strategies for achieving reliable suppression of combustion instability, including from within limit cycle oscillations, will be developed;*  an open-source low order combustor modelling tool will be developed and widely disseminated, opening access to researchers worldwide and improving communications between the fields of thermoacoustics and control the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'FIRST INSTANT, OFF-THE-LAB AND USER-FRIENDLY BLOOD GROUPING TEST' (ABOPEN) under Horizon 2020.

assistant: **Objectives**

Despite being eradicated from the developed world, the Rhesus Disease or HDFN (Hemolytic Disease of the Fetus and Newborn), a disease where the immune system from the mother attacks the red blood cells from their babies, still kills 141,000 children and mothers in developing regions every year. Deaths that could be easily prevented by screening pregnant women for their RhD factor type. Although 15% of RhD(-) women are at risk, 220 million women in developing countries should be tested, since the majority do not know their RhD factor type.At Eldon Biologicals AS (a Danish company created in 2002), we are a profitable company that has already sold millions of EldonCards (a pioneering off-the-lab dry format grouping test) in more than 44 countries and has built a well-established worldwide network of customers and distributors. We are part of the influential International Federation of Gynecology and Obstretics (FIGO) and founding member of CURhE, an international initiative to stop HDNF. Now, we are moving one step further from EldonCards overcoming its limitations to erase HDNF from developing countries. To do so, we have created ABOPEN, a user-friendly off-the-lab grouping test that can be stored for up to 24 months at 37C and works similarly to pregnancy tests, identifying the RhD factor type in just 1 minute and a single-step procedure. ABOPEN can be performed outside a laboratory setting (does not need electricity) by non-trained personnel, while keeping its affordability (it costs just €4), precision and accuracy. ABOPEN has also a sizeable market in developed countries, as an instant and easy to use device to find out about blood grouping for urgent transfusions (accidents, hospitals, military) or just personal information.By end of 2025, we expect to generate €8 m