RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Universal application 2 conduct Privacy Impact Assessment analysis and reports' (U2PIA) under Horizon 2020.

assistant: **Objectives**

We are Nier Soluzioni Informatiche (NSI), an innovative software company that operates since 2002 in the fields of security compliance, privacy compliance, and counselling on the protection of personal information in collaboration with law firms. We have a strong history and capacity to develop new products/services (10% revenue growth), a €4.2M turnover in 2015 and 80 employees currently, established commercialization channels, and an international customer base of both private companies (e.g. Philips, Nike, Magneti-Marelli, Scuderia Toro-Rosso) and public entities (e.g. Università di Bologna, Rizzoli Institute, San Raffaele Hospital of Milan, or AUSL –healthcare system of Emilia Romagna Region).  With the support of renowned legal experts focused on privacy and data protection (Orlandi-Leone Studio Legale), we are launching U2PIA, a disruptive cloud platform designed to enable the creation of in-depth analysis of the risks which Personal Data are subject to through a Privacy Impact Assessment (PIA). Our platform will address the requirements of the upcoming mandatory European regulation (EU) 2016/679 on Privacy Assessment that all private and public EU companies must meet, to avoid the large penalties and severe sanctions that they could suffer if proper action is not taken (failure to comply put the business at a risk of a sanction up to 20 million euros or, if higher, up to 4% of annual worldwide turnover). Thanks to U2PIA, not only do we expect about €3.1M revenue and ROI of 2.78 by the third year of business, but it will also help us become a cloud SaaS service leader provider.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigation of the functions of a novel protein, PRDM16, rearranged in cases of acute myeloid leukaemia with rare translocations' in the context of a Sixth Framework call.

assistant: **Objectives**

The proposed research project plans to investigate the functions of a novel protein, PRDM16 (MEL1), in leukaemogenesis. PRDM16 is a member of the SET domain family of histone lysine methyltransferases and was recently identified by the host laboratory to be rearranged in three cases of acute myeloid leukaemia carrying rare translocations.In the first case, full length PRDM16 is aberrantly expressed, whereas in the second case, a deleted PRDM16 lacking the SET domain (delPRDM16) is formed. In the third case, an AML1-PRDM16 fusion protein results. We plan to investigate how PRDM16, delPRDM16 and AML1-PRDM16 can give rise to AML. In particular we wish to investigate the importance of the SET domain, how fusion to AML1 alters the function of PRDM16, and whether AML1-PRDM16 can function in a similar way to AML1-ETO.In vitro assays will initially be performed to investigate the biological phenotypes induced by each protein (PRDM16, delPRDM16, AML1-PRDM16 or AML1-ETO). The proteins will be over-expressed in murine haematopoietic progenitor cells (lin- cells) and will be assessed for their ability to block myeloid differentiation, increase survival upon genotoxic stress, and increase self-renewal.In vivo assays will also be carried out to test the ability of the proteins to induce leukaemia in mice. In order to identify target genes commonly regulated by AML1-PRDM16 and AML1-ETO, Affymetrix gene expression microarrays will be employed. The proposed project will yield many important insights into the functions of PRDM16 and how its aberrant expression contributes to leukaemia.The researcher has a background in mapping fusion genes in cancer and will therefore greatly expand her repertoire of laboratory skills by performing functional studies on a novel protein. The project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Analysing the role of complement in antigen trafficking using intravital microscopy'.

assistant: **Innovation**

The immune system is continuously faced with the dilemma of distinguishing between self and non-self antigens. The complement system, a set of more than 20 serum proteins and receptors, is one of the critical components of the immune system involved in making this choice. Upon activation of the complement system in the peripheral tissues by a foreign antigen, complement components are covalently attached to the antigen. Complement receptors on dendritic cells (DCs) and follicular dendritic cells (FDCs) are then involved in the trafficking to, and presentation and retention of the antigen in the peripheral lymph nodes (LN).The detailed microenvironment in the LN, where the antigen is presented to T and B cells, determines whether or not an immune response is mounted. While these general characteristics of antigen trafficking and presentation are widely accepted, the fundamental requirements for complement activation and its role in antigen trafficking have remained unclear. Furthermore, it has so far been impossible to address FDC biology in vivo.In the current project I propose to visualize for the first time FDCs in vivo using novel techniques for intravital microscopy in an FDC-reporter mouse generated in the Carroll lab. I will generate reporter mice for complement factor 4 (C4). I will generate bone marrow chimeras from complement deficient mice, in the FDC- and C4-reporter mice and investigate the cellular source of complement, the location of complement conjugation to Ag, and the role of complement in t he transport of Ag to FDCs in secondary and tertiary lymphoid tissue upon intradermal exposure to Ag. My work will provide new insight into the processes of immune regulation and tolerance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Concept and feasibility assessment for AnandaCor, a fast melting tablet, as a diagnostic device in ischemic heart conditions.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Ananda Pharma GmbH qualified a plant derived active pharmaceutical ingredient (API) for specific heart diseases. In nanomolar doses the substance protects cardiomyocytes by stabilizing the Na+/K+ -ATPase. The API enables ischemic preconditioning and has a balancing effect on the energy metabolism of cardiomyocytes by enhancing the turnover of lactate to ATP. The specific mode of action conveys a larger therapeutic range which means a smaller risk for unwanted side effects compared to similar substances.The API targets mainly on the small vessels and the myocardial cell, rather than on the large vessels, and therefore can be useful to distinguish between relevant obstructive coronary atherosclerosis and the actual ischemia in the microvasculature or in the myocardial cell itself. These properties convey the great potential as a new diagnostic medical device for patients with angina pectoris due to ischemic heart conditions. Therefore Ananda Pharma GmbH developed AnandaCor®, an innovative tablet formulation of the active pharmaceutical ingredient.Since cardiovascular and ischemic heart conditions are highly prevalent in all industrialized countries, with over 2 million deaths per year and estimated external costs of nearly 110 billion € per annum in the European Union alone, there is an urgent need for effective diagnostic investigation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INTEGRATIVE VISION SYSTEM OF ON-BOARD SORTING OF EXPLOITED STOCKS AND REAL-TIME COMMUNICATION WITH LAND' (SEASCANN), addressing dissemination and exploitation.

assistant: **Impact**

SKAGINN is an Icelandic innovative company with <170 staff that was created in 1998. This leading SME supplies worldwide a high variety of own-developed processing equipment in the food industry. The novel SEASCANN we present here is a cutting-edge technology of pre-processing based on a vision system to classify catches on board depending on the species, size and commercial value. The system is two-folded integrated, (i) vision system, with a feeder, a vision unit, a separator and a batcher, and (ii) GPS connectivity system that transfers data to the Cloud in real time. This allows land operators to track catches by each boat immediately, and better plan marketing and sales. The system will make data available also to fishery inspectors and authorities so individual quotas can be monitored in real time, without any delay.SEASCANN improves by 35-65% the efficiency of conventional fishing sorting methods, and 10-15% of time saving for commercialization compared to current technology, due to real-time connectivity between on-board and land-based personnel. Thus, our disruptive innovation will allow fisheries' value chain to move forward maximum levels of efficiency by lowering production costs and optimizing market management. As a whole, SEASCANN will get results 15-25% more efficient than conventional methods of sorting and communication from boat to land.Real-time assessment and surveillance of fish stock from on-board would provide a closer interaction within the fishery industry, with a better plan marketing and sales, and also between fishery sector and authorities, with the possibility of adjusting managing fishery decisions.SKAGINN forecasts €106 million cumulative revenues for the period 2020-2022, and staff will be increased by 35 people. Profitability ratios in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'In vivo model to dissect the ras to rac signaling', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Knockout mice for e3b1 and its homologous e3b2 will be establish and analyze to investigate the role of E3b1 in the tri-complex with Eps8 and Sos-1 which is endowed with Rac-specific GEF activity in the signalling pathway leading to action remodelling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Oleophobic Elastomeric Gaskets made through Known Biomimetic Micro-Nano Surface Textures used for Automotive Seals in Contact with Oil or Fuels' to be submitted under Horizon 2020.

assistant: **Abstract**

The project SEALTEX aims at uptake by PLANET of the most recent technological improvements on micro-/nano-machining technologies to manufacture the first ground-breaking micro-patterned chemicals-free super-oleophobic gasket. SEALTEX is micro-patterned on their surfaces in order to achieve super-oleophobicity without using any kind of chemical coatings for several industrial applications (automotive engines among the others) waiting to use high-performing micro-patterned gaskets and seals resistant to oils and fuels, since they are currently strongly detrimental and injurious for their durability due to wear resistance issues (DWRI). Due to durability and wear resistance issues (DWRI) of gaskets and seals, which systematically occur during use, they become a severe and risky problem in different parts of vehicles (engine, chassis and car interiors) increasing breakages and malfunctions rates, and also potentially causing incidents and dangerous unsafe situations for drivers.GASTEX project meets the objectives of the SMEInst-02 topic: the harvesting in the automotive field of the hitherto untapped potential of cutting edge micro/nano manufacturing technologies by means of an innovative super-oleophobic gasket which has a potential for a wider deployment in very short time. First of all, there is no elastomeric gasket currently on the market able to efficiently prevent deterioration of both durability and shape due to swelling. Secondly, the prototype will be enhanced and validated by means of technical trials in real conditions in the Companies forming our European collaborators network. The feasibility study will also be used to submit a Phase 2 proposal in order to bring our technology from lab to market and thus, guaranteeing a wide market deployment. We believe that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Towards a New Theoretical Basis for the Training of Simultaneous Interpreters: The Role of Computers'.

assistant: **Objectives**

Research objectives and contentBringing together various disciplines including interpreting theory, comparative syntax, relevance theory, general courseware development theory and extensive study of existing CALL (Computer Assisted Language Learning) applications. The project will aim to develop a computer assisted interpreting training theory", thereby promoting the use of time-saving computer technology in the teaching of interpreting. The theory will be reflected in two programs for the teaching of simultaneous to beginners in interpreting. They will be based on a graduated learning approach. The use of audio and video clips, recording facilities and new voice-recognition software will ensure constant monitoring and immediate feedback.Training content (objective, benefit and expected impact)After receiving my first degree in Interpreting from the School for Interpreters and Translators of the University of Trieste. I believe that a training period of three years at the university of Hull, a leading centre in the production and dissemination of CALL materials, will greatly enhance practical understanding of the important role that computers can play in the Humanities.Links with industry / industrial relevance (22)In the light of ever-increasing interdependence between countries, a software package of the type envisaged would prove helpful in meeting the growing demand for skilled interpreters."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Unleashing a CoMprehensive, Holistic and Patient Centric Stroke Management for a Better, Rapid, AdvancEd and PersonaLised Stroke Diagnosis, TreAtment and Outcome Prediction'.

assistant: **Objectives**

UMBRELLA is a holistic approach to progress, reshape, and benchmark the overall stroke care pathway and set new and improved standards of care in terms of primary and secondary prevention, rapid access to treatments, early accurate diagnosis, stratification, management and real-time monitoring, therapeutic targets identification, and rehabilitation, recurrent stroke and related cardiovascular events. This innovative approach will transform healthcare systems by improving and harmonizing professionals' workflows in a more patient-centred, digitalized, and communicative manner. UMBRELLA aims to revolutionize stroke management by implementing a comprehensive approach that addresses gaps along the whole continuum of the stroke care pathway. The key paradigm in the project is the multicentric, synergistic ""umbrella"" strategy for local data collection, harmonization, and standardization along the entire pre-, in-, and post-hospitalization pathway. By establishing specific common data models (CMDs) implemented in each of the 7 top-tier European clinical centres, UMBRELLA will create a federated data platform (U-platform) where Real World Data (RWD)-based AI algorithms can be locally created and validated, to advance personalised diagnosis, risk prediction, and treatment decisions in the acute and post-acute phases of stroke. The algorithms will be then trained in a decentralized manner through a federated learning infrastructure (FL-platform), which preserve data security and privacy, avoiding data centralization or exchange across centres but fostering collective AI-models training. On the other hand, standardized stroke management protocols and procedures will be created and implemented across the participating centres, including the validated usage of advanced digital tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cracking the code and flow of empathy' (VicariousBrain), addressing dissemination and exploitation.

assistant: **Impact**

Humans are exquisitely able to sense the motor intentions and emotions of others. In the last decade, using single cell recordings in monkeys and fMRI in humans, I have contributed to show that (1) mirror neurons and brain regions involved in the execution of a goal directed action also respond to the sound and sight of other people performing a corresponding action and (2) brain regions involved in feeling an emotion also respond when witnessing that emotion in others. Here, I propose to explore two critical questions raised by these findings.1) How does the distributed network of brain regions involved in action observation integrate information across regions? We will use effective connectivity analyses of electrophysiological signals in monkeys (ECoG) and humans (EEG, MEG, ECoG) to explore the direction of information flow between these regions to challenge traditional models of action observation. Results might turn traditional models of (social) perception up-side-down by demonstrating that internal models are the driving force of perception.2) I will leverage an animal model of empathy we recently developed, to finally explore how neurons in brain regions associated with empathy respond during the experience and witnessing of emotions. Through a combination of PET, multi-tetrode recordings and deactivation studies, I will shift the focus of the neuroscience of empathy from fMRI blobs to neurons and their interactions across brain regions. Given the tremendous interest in emotional empathy across many fields, understanding its neural causes will open exciting new horizons for our mechanistic understanding of this fundamental human capacity and the therapy of psychiatric disorders of empathy costing our society hundreds of billions every year.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ENergy-efficient CONTROL with INternet-of-Things connected home solUtiOn'.

assistant: **Objectives**

We propose a connected home solution that helps reduce energy costs while preserving comfort for occupants. Oursolution, enControl™-Intuo, leverages the Internet-of-Things and integrates self-learning and adjusting capabilities forinteracting with any climate system, from wall units to central heating and air conditioning to radiators.As an added service to our enControl™ energy service platform for utilities, the innovation project integrates a proprietary algorithm to offer seamless energy efficiency to residential utility customers - saving energy and reducing their carbon footprint. The innovation will enable new business models for European utilities: 1.-New energy services to reduce consumption and carbon footprint in homes; 2.-User engagement & customer satisfaction; 3.-Accelerate adaptation to new sources of energy. The innovation is tailored not only to a home’s consumption patterns but also to its energy supply model. It optimizes energyusage with energy availability and variable energy tariffs considering the own-energy generation when computing the optimalpolicy. In addition, the algorithm learns user comfort preferences reducing user interaction with the system.Our solution allows interoperability of devices from different vendors. We address this challenge with a holistic, scalable andsecure Cloud-based software that seamlessly integrates new home devices and equipment and enables users to make theirhome smarter and more self-sufficient in the future. The solution allows for fast scalability to reach the large and lucrativeresidential market. With a next-generation service and a recurring monthly revenue model that fits most household budgets,we expect our solution to quickly gain traction in early adopter segments in Europe. These elements will allow us t