RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Topological Complex Systems'.

assistant: **Concept**

In dynamics, local behaviour is often very unstable, while global behaviour often is immensely hard to derive from local knowledge. Traditionally, topology has been used in abstracting the local behaviour into qualitative classes of behaviour -- while we cannot describe the path a particular flow will take around a strange attractor in a chaotic system, we can often say meaningful things about the trajectory as an entirety, and its abstract properties.<br/>We propose to use computational topology, which takes notions from algebraic topology and adapts and extends them into more algorithmic forms, to enrich the study of the dynamics of multi-scale complex systems. With the algorithmic approach, we are able to consider inverse problems, such as reconstructing dynamical behaviorus from discrete point samples. This is the right approach to take for complex systems, where the precise behaviour is difficult if not impossible to analyse analytically.<br/>In particular we will extend the technique of persistence to include ideas from dynamical systems, as well as incorporating category theory and statistics. Persistence is inherently multi-scale, and provides a framework that will support the analysis of multi-scale systems, category theory provides a platform for a unified theory and joint abstraction layers, and statistics allows us to provide quality measures, inferences, and provide confidence intervals and variance measures for our analyses.<br/>The combination of these four areas: category theory, statistics, and dynamical systems with computational topology as the joint platform for the three other components, will allow for a mathematically rigorous description of the dynamics of a system from a local to a global scale. In this framework, multi-scale features have a nat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New directions in radio-interferometric wide-field mapping' (WIDEMAP).

assistant: **Concept**

The main science driver for our proposal is to develop novel algorithms to produce wide-field maps from radio-interferometric astronomical observations. The technique of Very Long Baseline Interferometry (VLBI) achieves the highest resolution of astronomical observations at any wavelength. Until recently, the size of maps produced by VLBI was limited to tiny regions on the sky. Based on our previous experience in pushing VLBI to larger fields, we will develop methods that allow real wide-field VLBI using affordable computer hardware. In combination with the development of new algorithms, we will use special-purpose hardware that was originally developed for graphics processing. This hardware, available in the form of high-end graphics cards, provides high performance for a low price and is well-suited for our applications. Using this type of hardware is currently also explored in other areas, and we plan to combine the main goal with other fields of astrophysics. Closest to the wide-field mapping project are applications in modelling gravitational lenses and calibrating and imaging data from the new LOFAR radio telescope array. On the more distant side, we will explore the opportunities for numerical N-body simulations, one of the active research areas at the host institute.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cryptography with Low Complexity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The efficiency of cryptographic constructions is a fundamental question. Theoretically, it is important to understand how much computational resources are needed to guarantee strong notions of security. Practically, highly efficient schemes are always desirable for real-world applications. More generally, the possibility of cryptography with low complexity has wide applications for problems in computational complexity, combinatorial optimization, and computational learning theory.In this proposal we aim to understand what are the minimal computational resources needed to perform basic cryptographic tasks. In a nutshell, we suggest to focus on three main objectives. First, we would like to get better understanding of the cryptographic hardness of random local functions. Such functions can be computed by highly-efficient circuits and their cryptographic hardness provides a strong and clean formulation for the conjectured average-case hardness of constraint satisfaction problems - a fundamental subject which lies at the core of the theory of computer science. Our second objective is to harness our insights into the hardness of local functions to improve the efficiency of basic cryptographic building blocks such as pseudorandom functions. Finally, our third objective is to expand our theoretical understanding of garbled circuits, study their limitations, and improve their efficiency.The suggested project can bridge across different regions of computer science such as random combinatorial structures, cryptography, and circuit complexity. It is expected to impact central problems in cryptography, while enriching the general landscape of theoretical computer science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Perception of Other Religions', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of the research project  is to provide an extensive analysis of the perception of other religions and their members by Christian authors of the Early and High Middle Ages from the fifth to the twelfth centuries. For the first time ever, the medieval perception of heathens, Jews, Muslims, heretics and Orthodox Christians, as they are seen by Occidental Catholics, is explored in a comparative and comprehensive manner. The project, therefore, will provide an invaluable contribution to religious thinking, the understanding of religion, the concept of ""the other"" and the (religious) concept of self.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enantioselective synthesis of a protein tyrosine kinase inhibitor - radicicol' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The key feature of this proposal is to develop a new methodology for the synthesis of radicicol and other analogs in an efficient and selective manner. These receptor tyrosine kinase inhibitors are of great importance for pharmaceutical research and may open up alternative and better routes to study the inhibition of membrane bound protein tyrosine kinase (PTKs). Understanding the mechanisms of the inhibition in cells is an important and revelant subject to study malfunctions in the developent of cancer and other related illness. Synthesis of PTKs inhibitors provide an important entry to such studies. In this way PTK inhibition assays will be carried out to study our own compounds as possible PTK inhibitors. Further biological studies will be proposed in the light of the results of the previous assays. Combination of our chemical techniques with other biological methods, will afford a good entry for research in Biooganic Chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RO-Boost Inno SMEs – Boosting the Innovative Potential of Romanian SMEs'.

assistant: **Objectives**

In the context of innovation-divided Europe and scarce consultancy in RDI, Macro Region 4 Romania is in full process ofmoving towards a ""turning point"" of economic positioning in a climate of globalization, disruptive innovations and circulareconomies. This dynamic brings to surface impediments innovation actors in the region face multiple challenges, while theirability to overcome them is crucial to the impact of such changes. The core members of the Ro-Boost SMEs consortium areaware that it is time for smart action in order to achieve the goal of reducing the innovation divide among companies. Basedon the vision stated in the Ro-Boost SMEs Implementation Strategy, the core members of the consortium jointly elaboratedthe project ""Ro-Boost Inno SMEs"" aimed at consolidating innovative businesses - rooted into the Smart SpecialisationStrategy - and to expand their position within the sector global value chains. To achieve this goal, dedicated innovationsupport envisaged at the beginning of 2015 shall be continued in order to increase added value of SMEs and innovativesectors in the global economy, using an innovative delivery system and consolidating the community of innovators.The proposal is built around the expertise of relevant partners at Macro Region 4 level and in-depth competences gained in2015-2016. It shall also capitalize on the impact generated in the previous period in order to gain further recognition of theinnovation management as success driver among SMEs in terms of both economic impact and innovation culture withinbusiness environment.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of Gene Therapy Strategies for Neurological Diseases' under Fourth Framework.

assistant: **Concept**

The aim of the proposed project is to develop procedures for gene and cell therapy for application in the treatment of neurological diseases, in particular Parkinson's disease and epilepsy.  Approaches will involve gene therapy strategies using both ex vivo and in vivo direct injection to induce production of neurotransmitter and neurotrophic molecules. The project includes all levels of analysis and stages of development from the production of viral vectors, genetic manipulation and encapsulation of cells, in vivo gene transfer, to the preclinical assessment of procedures in preparation for clinical trials with patients. The proposed research addresses two neurological diseases: Parkinson' s disease (PD) and epilepsy, affections chosen because their pathophysiologies suggest possible therapeutic agents: neurotransmitter, trophic factors or both. Both ex vivo and in vivo gene therapy strategies will be developed in five partially overlapping phases:Types of cells suitable for genetic manipulation and intracerebral transplantation will be identified, and the tools to transfer genes for neurotransmitter-synthesising enzymes and neurotrophic factors constructed.Suitable types of cells intracerebrawill be identified and the tools to transfer genes for neurotransmitter-synthesising enzymes and neurotrophic factors constructed.Encapsulation techniques for the transplantation of genetically engineered allo and xenogeneic cell lines will be tested.The functional properties of the transduced cells in vitro and of recombinant adenoviral constructions will be analysed in detail, and the functional efficacy of DOPA/dopamine and neurotrophic factor-producing cells in well characterised in vivo models assessed.Alternative gene constructs where the transgene is under the control of en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Signalling and Membrane Trafficking in Transformation and Differentiation' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Intracellular communication in eukaryotes is largely achieved by the trafficking of membranes carrying membrane-bound and/or intravesicular signalling molecules.Inside cells, vesicles circulate from one intracellular compartment to another thus facilitating vectorial transport of signals.Between cells, membrane anchored and secreted soluble molecules mediate extracellular signalling.Exocytosis and endocytosis of receptors control the response of sensitive cells to extracellular signals.The routes of membrane trafficking are controlled by cell signalling pathways but the underlying molecular machinery is scarcely characterised. Moreover, membrane trafficking has been studied mainly in differentiated cells and rarely in cells changing phenotype during differentiation or dedifferentiation.Such drastic phenotypic changes occur during development when cells mature to differentiated cells as complex as neurons, and during malignant transformation.The goal of this STREP is to establish the connections between signalling pathways and membrane trafficking in the context of migrating, dividing and adhering mammalian cells.Through the study of membrane traffic in the course of cell differentiation, dedifferentiation, and during mitosis, we aim to unravel how important signalling pathways remodel the intracellular trafficking routes and conversely,how membrane traffic can influence signalling cascades.We will take advantage of several cellular models including neurons differentiating in culture and cancer cells dividing and migrating. We will investigate proteins that play central roles in membrane trafficking and secretion such as rabs,SNAREs and their partners. We will focus on the trafficking of signalling molecules including cell-cell and cell-substrate adhesion molecules, grow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Imaging of MUscle Shape Changes during eLEctrically-stimulated contractions'.

assistant: **Innovation**

When we move, our muscles contract, and by doing so change shape. While such shape changes are obvious and are required for a muscle to increase its force, we know little about its functional role in force production. Muscle force is one of the most important parameters in the science of movement, yet it remains impossible to measure in humans. Understanding the precise link between muscle shape changes and muscle forces and advancing methodologies for measuring such muscle shape changes can thus have an important fundamental and ultimately also clinical scientific impact. In I-MUSCLE, I propose to first advance innovative techniques for measuring whole muscle shape changes during muscle contractions, and secondly, to use these advancements to answer key questions about 3D muscle shape changes and its role in force production. I will take an in situ approach to study the calf muscle of guinea fowl (Numida meleagrisis L.). I will stimulate the muscle to induce steady-state contractions at different muscle-tendon unit lengths, at different activation levels, and during concentric and eccentric dynamic contractions. I will measure the muscle shape changes by using state-of-the-art imaging modalities, i.e. ultrafast computed tomography (< 2s) and high-speed stereo (3D) X-ray videography (up to 750 Hz), while also recording muscle forces. The shape changes will be assessed (i) when the muscle is activated globally and (ii) when the muscle is activated locally in specific parts of the muscle. The latter is relevant given that we often activate only parts of our muscles, for example during walking or when using electrical muscle stimulation for rehabilitation purposes. Gaining a better understanding of how muscles change shape under realistic conditions and how it is linked to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Have Fun with Science, Love Science and Live Science' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The “FuLL-Science (have fun with science, love science, and live science)” Project aims at ensuring the understanding of science and technology by the society offering innovative scientific and technological learning opportunities such as seminars, demonstrations, panels, competitions etc. from elementary education level to Adult education level as well as the people who drop out education. The FuLL-Science project is confident to reach this aim by promoting the following actions: The first approach (Have fun with science) is to help participants “have fun” with science. We plan to organize various activities, such as games, animations, entertainments, workshops, plays, theatres, music, dance, etc. that meet the participants in all ages with the amusement in science. We want to illustrate how science is enjoyable by a mix between science and art, theatre, and literature. The second approach (Love science) is to introduce the participants with the “love” part of the science, which we conceive as how scientists fell in love with science, and thanks to this love how they become productive in their respective fields and how scientists are ordinary people who are also have hobbies. That is, we would like to help the participants to recognize the scientists and their work by presenting them opportunities to meet with scientists and their studies. The third approach (Live science) is to assist the participants be acquainted with how they “live” science in their daily life. For example, we will present them opportunities to see how science is in our life, to experience the science in daily life by hands-on and minds-on activities, and to shape their view of science as a way of knowing. The participants will also realize the scientific developments in various fields by meeting a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Controlling oxidative deterioration during manufacturing and storage of healthy seafood products prepared from an under-utilised fatty fish species' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Fatty fish are rich in long chain polyunsaturated omega-3 fatty acids, which are known for their health effects and excellent nutritional value. However, in spite of their availability, low price and good nutritional value, some fatty fish species are under-exploited. The idea of the project is to exploit the nutritional properties of these species by producing healthy fish minces.However, fatty fish are difficult to process due to their high content of polyunsaturated fatty acids, which are very sensitive to oxidation. Lipid oxidation occurs during processing and storage of fatty fish and result in formation of compounds affecting nutritional properties and sensory quality of fatty fish products. Oxidised lipids interact with proteins inducing modification of texture and colour. The aim of this project is to produce high quality fish minces, but to reach this objective it is indispensable to understand mechanisms of oxidative reactions in order to control them during processing and storage.The second objective is therefore to gain a better understanding of oxidative deterioration processes and especially to unravel mechanisms involved in interactions between products of lipid and protein oxidation. The understanding of these reactions will help us to develop efficient antioxidant strategies to protect both lipids and proteins against oxidation. Horse mackerel mince with different lipid contents will be used in the project. After evaluating the oxidative stability during manufacturing and storage of fish mince, the study will focus on determination of lipid and protein oxidation in model systems by modulating different oxidative levels of proteins and/or lipid.The last stage of the project will focus on optimisation of production of fish mince of high nutritional value