RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Glioblastoma Inhibition: Targeting Tumour-derived Extracellular-Vesicle Driven Cell-Recruitment' (GLITTER).

assistant: **Innovation**

Glioblastomas (GBMs) are malignant brain tumours and among the most aggressive human cancers. GBMs patients have an extremely poor survival rate due to a complete absence of adequate therapies capable of efficiently targeting GBM cells inside the brain. Recently, we demonstrated that GBM cells release pro-tumoural extracellular vesicles (EVs) into the bloodstream, which emerged as important intermediates in communication with distant peripheral cells in the body. Of note, the distribution of GBM-derived EVs can now be monitored in vivo by employing a novel Cre/LoxP mouse reporter model. This sophisticated imaging model enables the visualisation of normal peripheral cells that have taken up circulating GBM-derived EVs and allows for subsequent tracking of the recruitment of these cells to the tumour. Recent studies have shown that GBM-derived EVs have the capability to manipulate non-neoplastic cells, exploiting them for tumour expansion. Moreover, we have preliminary evidence that GBM-derived EV receptor pathways can be identified and blocked, possibly causing stagnation of GBM tumour growth by preventing recruitment of essential support cells. We aim at identifying these pathways using unbiased RNAi screening, followed by interference with pro-tumoural cell recruitment, using small molecule drugs in our GBM in vivo models. Finally, circulating GBM-derived EVs and their RNA content are also efficiently captured and internalised by blood platelets (PLTs) that can act as efficient EV carriers. Hence, tumour-derived RNA in circulating EVs and PLTs, isolated from the blood of GBM mouse models and patients, may serve as non-invasive biomarkers and companion diagnostics platform. GLITTER aims to; 1) Analyse in detail the EV-driven recruitment and signalling of essential GBM s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Therapeutic strategies using vegf substitutes and gene therapies to maintain the integrity of the arterial wall' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The Partners have proposed a new hypothesis whereby vascular endothelial growth factor (VEGF) is arterioprotective in intimae hyperplasic and arteriosclerosis. That cell signalling of the VEGF family, which underlines the production of NO and PGI_2, is the basis of the arterioprotective effect will be elucidated. Peptides will be synthesised and used as probes and as substitutes for the VEGF receptors in functional studies. The peptides will be the basis of future cytoprotective medicines. Rabbit and mice models of VEGF protective functions will be used. Novel VEGF- and PIGF-induced genes will be discovered leading to novel therapies. Transgenic mouse models lacking or expressing mutant forms of the VEGF family of genes will be used to evaluate the vasculoprotective role in intimae hyperplasic and arteriosclerosis. This project will elucidate the mechanisms involved in arterioprotection by VEGF and produce novel arterioprotective therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BUILDING ENERGY EFFICIENT SYSTEM THROUGH SHORT AND LONG SPECTRUM THERMAL ENERGY STORAGE' (BEST-Storage).

assistant: **Innovation**

Buildings consume most of the world’s electricity and as much as 50% of their consumption is used to cover thermal demands. Some actual developments, such as the growing use of electrical vehicles and the usage of heat pumps, are affecting electricity consumption and peak demand, and their impacts will only increase in the future. The excessive high energy demand entails significant negative environmental and economic impacts. Consequently, it is imperative to increase use of demand response strategies that shift electricity use from peak to off-peak periods. The BEST-Storage project is an important step to achieve the goal of peak load reduction and shifting, energy saving and energy cost minimization. Moreover, technologies for storing renewables for longer time-spans of months or seasons are scarce and costly and thus not widely used yet. Large amounts of energy are needed for heat supply of buildings in cold winter months, when solar energy is scarce and in general when renewable sources cannot cover the demand. Thus, seasonal storage solutions will be a necessary technology for a full decarbonisation of the energy supply system. In BEST-Storage, long and short-term high-energy density storage solutions will be developed and demonstrated in four demo cases around Europe. A thermo-chemical and loss-free storage technology will be developed as a seasonal storage. Two phase change materials slurry concepts and a vacuum insulated water storage will be developed, for cold and warm applications respectively, with the aim of shifting peak load demands. Finally, storage solutions will be integrated within smart building energy management systems featuring model predictive controls to reduce operation cost for short-term applications.


**Keywords:** Thermal demands,  electr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neuromodulation of sensory perception and memory: a combined behavioral, electrophysiological and computational approach' under Sixth Framework.

assistant: **Concept**

The overall goal of the projects in which the current proposal is embedded is to investigate the roles of different neuro-modulator systems in sensory processing and memory. For example, work in our laboratory has indicated that the effects of cholinergic modulation in the olfactory system go substantially beyond its generally assumed role as a modulator of attention. A major advantage of the olfactory system as a model system to study cholinergic neuro- modulation is that it receives a unique cholinergic projection from the horizontal limb of the diagonal band of Broca; as a consequence, specific manipulations to this projection will affect only the olfactory system. On the other hand, the olfactory bulb is unique among cortical brain structures in that it contains intrinsic dopaminergic neurons that mediate all dopaminergic modulation therein; no centrifugal dopaminergic fibres project into the bulb.The olfactory system presents a unique opportunity to investigate the respective roles of intrinsic versus extrinsic neuro-modulation in stimulus processing. Similarities in early onset olfactory deficits observed in patients with Alzheimer's and Parkinson disease suggest that the specific roles of the two modulators may easily be confounded in some olfactory tests. Because odour perception cannot be measured without odour learning, effects on detection thresholds and effects on learning are difficult to disambiguate. To further investigate the respective roles of these modulators, we are currently testing how both types of modulation affect odour processing.As is the custom in our laboratory, complementary behavioural, electrophysiological and computational modelling studies will be performed; it is the combination of these three approaches that allows us to systematicall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterization of Key Epigenetic Targets in Hepatic Fibrosis and Hepatocellular Carcinoma Development. Generation of New Antifibrotic and Antitumoral Drugs.'.

assistant: **Objectives**

Liver fibrosis represents a common pathogenic pathway in most chronic liver diseases (CLDs) and cirrhosis, its end stage, is a huge healthcare burden. The main causes of CLD are chronic viral hepatitis B or C infection, alcohol abuse and obesity-linked steatohepatitis, conditions with increasing global incidence. Hepatocellular carcinoma (HCC) develops on this background of CLD as a multistep process in the context of chronic inflammation and cirrhosis. Among all non-hematological malignancies, HCC has the fastest rising incidence of any neoplasm in USA and Europe. Despite all the progress in understanding the cellular and molecular mechanisms of liver fibrosis and hepatocarcinogenesis, there are no effective therapies to halt fibrosis or quell liver cancer. Exposure to environmental factors triggers adaptative epigenetic mechanisms, including alterations in DNA methylation or post-translational modification of histones, which control gene expression and ultimately cellular behaviour in ways critical for the development of CLD and HCC. From the literature and our preliminary observations it is known that many of the enzymes carrying out these epigenetic events, such as DNA and histone methyltransferases, present altered expression and activity in CLD and HCC. The deposition of methyl marks in histones and DNA are very dynamic enzymatic processes, amenable to pharmacological intervention and therefore constitute attractive therapeutic targets. Our proposal has two main objectives: first the analysis of the expression, activity and pathological significance of DNA and histone-methyltransferases in models of CLD and hepatocarcinogenesis; and second the development of new efficacious DNA and histone-methyltransferase specific inhibitors with a good safety profile, which is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New MilliDrop Analyzer: miniaturized and faster clinical microbiology testing in only one drop' (MilliDrop), addressing dissemination and exploitation.

assistant: **Impact**

MilliDrop pioneering millifluidic technology to study microbes will massively advance the fields of microbiology worth €7bn worldwide. Manipulation of microbial cell culture in only one droplet (~100nl), together with automation and extraordinary parallelisation (1000 samples), stands to deliver new products for medicine and biotechnology. It will close the gap from lab to market and revolutionize the microbiology analysis after hundreds of years of standard Petri dishes technology.The MilliDrop Analyzer is a unique, miniaturized and fully automated instrument for microorganisms’ fast culture and analysis. Each microorganism is grown in one droplet in a capillary containing several thousand droplets separated by air bubbles. Each droplet is monitored and measured in real time, enabling identification of infectious stains much faster than other existing technologies (6h vs 24h). Followed by immediate antibiotic susceptibility testing (AST) in the same instrument, it allows to obtain AST result in less than 12h after receiving the patient sample, instead of standard 48h. It opens extraordinary opportunities in clinical diagnostics enabling earlier and more precise diagnosis of infectious disease, giving a possibility to select and dose specific antibiotic early enough. It will reduce therapeutic failures by 60% and helping to combat antibiotic resistance which is a highly growing European and worldwide health challenge.The proposed SME Instrument objective is to develop, validate and industrialize a new version of Medical Device Analyzer for in vitro diagnostic (IVD) clinical microbiology market. The first generation dedicated to the research and development market is already in the industrialization process. IVD version will be launched in 2020 and will enable the compan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Managing Interactions between International Agreements: Dealing with Diversity in Global Climate Governance' (CLIMATEGOV) under Seventh Framework.

assistant: **Objectives**

The proposal seeks to support the career development of an experienced researcher, by completing an interdisciplinary research project on dealing with interactions in global climate governance, and enabling the fellow to acquire new knowledge and academic skills at a renowned university. The scientific objectives of the research are to analyse how the diversity in global climate governance, and interactions between different international agreements have affected the normative development of these agreements; to assess legal techniques and political mechanisms for dealing with the diversity in global climate governance; and to provide policy and research recommendations, and disseminate the findings of the research project. Three cases are used to illustrate the interactions, and to assess the legal and political options to manage interactions. These cases allow for a comprehensive analysis of the various forms of fragmentation in global climate governance, while at the same time providing broader insights for other areas of international law and global governance studies. The host institution for the fellow is the Environmental Change Institute (ECI) at the University of Oxford. ECI hosts many experienced scholars relevant to the proposed research, and has an excellent reputation in interdisciplinary climate change research. The Institute also has an outstanding track record of training researchers. The research training objectives are to contribute to the fellow’s writing and publication skills, through significant progress in completing his doctoral thesis and the publication of peer-reviewed articles; to enhance the fellow’s knowledge on interactions in global environmental governance; to participate in postgraduate courses, lectures, seminars and other events held
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Implementation of activities described in the Roadmap to Fusion during Horizon Europe through a joint programme of the members of the EUROfusion consortium' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EUROfusion’s updated Fusion Research Roadmap aims to acquire the necessary knowledge to start constructing a demonstration fusion power plant (DEMO) five years after ITER is in full-power operation. DEMO will deliver fusion electricity to the grid early in the second half of the century. The Roadmap has been articulated in eight different Missions. The present proposal has the goal of implementing the activities described in the Roadmap during Horizon Europe through a joint programme of the members of the EUROfusion Consortium, with the following high-level objectives: 1.Construct and commission ITER; 2.Secure the success of future ITER operation via preparation and experiments on present devices;3.Develop the conceptual design of a DEMO fusion power plant;4.Finalise the design and construct a fusion spectrum neutron source (IFMIF-DONES);5.Advance the stellarator as an alternative approach to fusion power plants;6.Prepare the ITER and DEMO generations of scientists, engineers and operators; 7.Promote innovation and European industry competitiveness in fusion technology and beyond.The ITER success remains an important overarching objective of the programme and much attention is devoted to ensure that ITER operation is properly prepared, and that a new generation of scientists and engineers is thoroughly educated and trained for its exploitation. DEMO is the only step between ITER and a commercial fusion power plant. To achieve the goal of fusion electricity demonstration in the early 2050-ies, the DEMO Conceptual Design has to be completed by 2030 at the latest, to allow the start of the Engineering Design Activities. DEMO cannot be defined and designed by research laboratories alone, but requires the full involvement of industry in all technological and systems aspects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Constrained Quantum Dynamics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Recently, tremendous progress has been made in exploring non-equilibrium dynamics of correlated quantum matter. The project ConsQuanDyn investigates the relaxation dynamics and the dynamical quantum phases, induced by parameter quenches or by periodic drive, in quantum matter with dynamically constrained excitations. Such constrained systems, which can be dual to gauge theories and host exotic topological order, have been recently realized in Rydberg quantum simulators and have a long tradition in condensed matter physics. However, it is an important open challenge to describe and understand their far-from-equilibrium dynamics. The central focus of the project ConsQuanDyn is to develop new concepts and new theoretical methods to study constrained quantum systems far from thermal equilibrium.The project has three principal objectives each of which would represent a major contribution to the field:(O1) To identify glassy dynamics and hydrodynamic transport in constrained quantum lattice gas, quantum dimer and fracton models.(O2) To demonstrate information scrambling and entanglement growth in constrained Hilbert spaces.(O3) To predict exotic dynamical quantum phases and to study their dynamical criticality both in quenched and in periodically driven constrained systems.To successfully meet our ambitious objectives, my team and I will develop two complementary theoretical approaches based on exact numerical techniques and on non-equilibrium field theory. This allows us to understand fundamental dynamical properties of constrained quantum systems and to guide future experiments. Constrained quantum systems may realize topological quantum bits and self-correcting quantum memories. Due to the international effort of inventing new quantum technology, that inherently operates o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Volatility modelling and transmission effects between financial markets - the European evidence' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content There is an obvious necessity for a correct specification and modelling of volatility for decision and policy making both in the macro and microeconomic levels (i.e. option pricing, risk hedging, asset allocation, market liquidity, income, consumption, savings, monetary policy and real state). We understand that the methodological and empirical research done on the characterization of volatility measures in the financial markets clearly lack an European content. In this direction, this proposal tries to fill in an empty space in the academic literature. The extent of international financial integration has received much attention in recent years. However, its empirical implications for the functioning of individual stock markets has received far less attention. In this research project we will tackle the short and long term relations among security price volatilities across the major and smaller European stock and options markets. We are interested to consider the short and long term relationships among financial price volatilities across the major European financial markets (London, Paris and Frankfurt) and how these relationships can affect the development of all those so-called satellite" markets bearing in mind the proximity of a full European financial integration. The proposal is then clearly divided in two phases: (1) the study and modelling of different volatility measures for specific European stock and options markets as a previous step towards (2) the analysis of volatility transmission effects among them. Keywords: Volatility Modelling, European Financial Integration, Volatility "Contagion" Effects, International Financial Integration. Training content (objective, benefit and expected impact) The host institution has an outsta