RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Demonstration of a novel thermo-chemical heat storage system to improve energy-efficiency in CHP power plants and in solar driven industrial applications with high relevance in SMEs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The FP7 R4SME HeatSaver project (Grant Agreement No.: 222116) successfully developed a zeolite based thermo-chemical heat storage concept at an integrated 1000 litre scale with significant advantages compared to SoA technologies in terms of energy density and flexibility. HeatSaver was assessed by the EC Research Executive Agency(REA) as delivering high quality science and technology development: That the project made good progress, achieving most of its objectives and technical goals with only relatively minor deviations. The REA also noted that “further development of the concept would be effective in close collaboration with potential end-users to enable simplification of system components and their optimization”.HS-DEMO will bring HeatSaver RTD results closer to market, within six months of the completion of this project, the SME partners seek to achieve sales of units. This project will result in an industrially and commercially viable thermal storage system that has wide applications. The demonstration project will involve: 1) Industrialisation of the manufacturing process through a Value Engineering approach. 2) Enable economies of scale in manufacture. 3) Validation of a commercially viable process that can be marketed with a reasonable return on investment by customers; requiring the recovery of heat at a cost of less than €50 to €90/MWh. This cost will be an economic target of HS-DEMO. 4) The need to demonstrate the technology over extended periods in industrial locations. Outline agreement has already been obtained for this from power plant company, CHP plants and solar thermal plants. 5) The demonstrations to be shown to relevant potential customers from across industry and across Europe (over 25 visitors), in a format that is able to show it to be of potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The New Ecology of Expressive Modes in Early Modern South India' (NEEM).

assistant: **Concept**

Southern India in the fifteenth, sixteenth, and seventeenth centuries comprised a single, strongly interwoven, multilingual cultural world that generated innovative literary, musical, theatrical and visual masterpieces as well as a theoretical erudite literature that explored the aesthetic and philosophical bases of these new works. New literary genres such as the compact, self-contained prabandha narratives crossed linguistic boundaries, emerging in and rapidly coming to dominate Tamil, Telugu, Kannada, Malayalam, and the trans-local languages of Sanskrit, Persian, Marathi and Dakhni.  Such texts, seen together with major genres evolving in the other expressive domains (the early varnams and kirttanas in music, the great mural paintings of the Tamil and Karnataka regions, Kudiyattam drama), were building blocks of an eco-system whose rules, themes, forms, and intertextual relations have never been studied as a whole. We propose to explore this large corpus in relation to the new grammars of language, poetics, music, drama, and painting that evolved at the same time. Among major themes common to all these traditions are the interiority and states of mind of the individual human person, the question of how such a person is created and fashioned, the problem of the fate or destiny that a person faces or generates out of himself or herself, and the autonomy of the natural world within which he or she lives and acts. All the major expressive domains, with their thematic and theoretical continuities, give voice to a historic shift in the dynamics and underlying axioms of south Indian civilization at the start of the modern age; this shift becomes fully articulate and apparent only when we see the expressive eco-system as a whole.


**Keywords:** South India, Tamil, Telugu, M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Exploring the Neighbourhood Planning Factors that Influence Residential Wellbeing'.

assistant: **Concept**

The United Nations has a goal to promote good health and wellbeing by 2030 (SDG3). The extent to which people are satisified with their neighbourhoods (their residential wellbeing RW) can account for up to 15% of their overall life satisfaction (mental wellbeing). Previous research applied qualitative and quantitative methods to understand the relationship between neighbourhood planning and wellbeing. However, due to the inconsistency in defining the spatial scale of neighbourhood and the failure to capture neighbourhood complexity in analysis, there has not been yet a comprehensive evidence-based framework of neighbourhood planning factors that influence RW. Therefore, this project (WellbeMap) aims to explore the neighbourhood planning and design factors associated with RW and whether those factors are objective or depend on individual residential needs. WellbeMap will take Dublin 8 (D8), a district in Dublin, Ireland, as a case study. It will (i) collect social data to identify subjective neighbourhood boundaries, neighbourhood needs, RW and urban planning data in D8; and (ii) analyse the relationship between urban planning data, RW and neighbourhood needs. Through the combined expertise of the applicant and the supervisor and the research environment at Maynooth University Social Science Institute (MUSSI) and the ADAPT centre, we will translate the concept of RW into a framework of factors that urban planners can control. This will contribute to people's mental wellbeing and, in turn, advance progress towards SDG3. WellbeMap will also have an impact on the applicant and the host organisation through the exchange of knowledge between MUSSI, ADAPT and the applicant. MUSSI and ADAPT will advance the applicant's career by building her capacity in quantitative spatial ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms of Poly-Ubiquitin Chain Assembly by Ubc7, a Ubiquitin Conjugating  Enzyme of the Protein Quality Control System' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Cell function and viability are dependent upon proper protein folding. To avoid abnormal and toxic deposition of proteins, the cells recruit the ubiquitin-proteasome system, by which ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s) work together to assemble poly-ubiquitin chains on misfolded or misassembled proteins, to be marked for degradation by the 26S proteasome.  With the maturation of the ubiquitin research field, a number of general principles have emerged about the enzymatic mechanisms of ubiquitin ligation to proteins. In particular, several high-resolution structures of different E2 and E3 enzymes have been determined, and these have yielded many insights into the mechanisms of ubiquitin-protein attachment. However, despite these advances, the fundamental mechanism(s) of ubiquitin-chain assembly remains unknown. The textbook version- which has not been proven incorrect- holds that ubiquitin molecules are added one at a time, first to the substrate protein and then to the distal end of the growing ubiquitin chain. Conversely, several recent publications have challenged this view by showing that polyubiquitin chains can pre-form on the catalytic cysteine of Ubc7, an E2 enzyme of the protein quality control ubiquitylation system, prior to transfer into a substrate. This led to our hypothesis that polyubiquitin-Ubc7 conjugates may represent an intermediate form, en route towards substrate ubiquitylation. Our specific aims are designed to provide a comprehensive evaluation of the enzymatic steps that precede substrate ubiquitylation in protein quality control pathways, with experimental emphasis on Ubc7-mediated ubiquitin chains catalysis. To this end, it is necessary to setup both cellular and cell-free ubiquitylation systems to provide the basic t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improved Vaccination Strategies for Older Adults' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ISOLDA aims at the development of improved vaccines for older adults against viral diseases with highest burdens at old age, by promoting virus-specific T cell responses in vaccinees over 65 years, using modulators of T cell immunosenescence and inflammageing. It builds on leading interdisciplinary expertise and knowledge of ISOLDA partners in virology, (onco-)immunology, ageing and immunosenescence, to assess the potential of immunomodulators, including kinase inhibitors licenced for other human use, to improve vaccine-induced immune responses and safety in older adults. ISOLDA partners have shown that these compounds may indeed restore key immunosenescent signatures. They will investigate ex-vivo signatures of immunological ageing and restoring potential of selected compounds on vaccine-induced immune responses against influenza virus, using PBMC from past and on-going adult and ageing human cohorts of influenza vaccinees. Cohorts of vaccinees and/or patients for tick-borne encephalitis, Middle-East respiratory syndrome and SARS-CoV-2 are also uniquely available to ISOLDA to demonstrate broad applicability of the approach. The most promising compounds will be tested in in-vivo animal models for vaccination against these diseases. As a proof of concept, ISOLDA will aim at improving the efficacy of a licensed vaccine against a respiratory virus, up to Phase I or II clinical trial with a lead immunomodulator compound or combination of compounds added to the vaccine formulations. The choice of Phase I or Phase II study design will depend on the compound, which will be selected based on results obtained upon prior in-vitro testing and in vivo testing in animal models. Promising SMKIs and/or oleic derivatives will be combined with a licensed MF59®-adjuvanted  and a non-adju
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EUROPEAN INDUSTRIAL BREAKTHROUGH LEADING TOWARDS AN INTEGRATED COMPETITIVE SUSTAINABLE INDUSTRY', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project focuses essentially on integration, aiming at bringing together stakeholders and visions in different dimensions among the NMP communities and the NMP and Manufuture research communities and industrial communities. It will materialise through the organisation of an NMP-Manufuture Conference in Belgium. It will address three major objectives: the interaction, complementarities and synergies between the ‘sub-themes’ of the NMP theme in FP7, between the NMP and Manufuture communities and the ‘research for integrated industrial implementation’ through the Manufuture Technology Platform and the related FoF under the EU Recovery Plan. The conference will feature a common policy: oriented plenary session for both objectives, information day sessions integrating the NMP and FoF initiatives. It will also organize brokerage events for project participants and invite potential applicants, and more particularly SMEs. An ‘integrated Research and Industries’ exhibition is also planned. The conference would gather an international forum to evaluate to what extent integration among the NMP components has been effectively realized and how this could further be materialised and amplified. It would present the preliminary results of the FP6 and FP7 projects, involve the related European Technology Platforms, and the three PPPs or the Recovery Plan, as well as the perspectives of the NMP programme to the scientific public and decision makers. It will promote integration through the Manufuture Technology Platform acting as the integrator of the enabling technologies in the FoF and acting as enabler of the production of the micro and nanotechnology-based products and products composed of new materials. The event would be most timely since it will coincide with the mid-term of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Widening the Scientific Excellence for Studies on Women’s and Fetal Health and Wellbeing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Given that one in six couples face infertility, often caused by female factors, women’s reproductive health is a significant medical and socio-economical challenge. Herein, while addressing this issue, the Estonian research on female reproductive health and medicine has rapidly developed with the lead of University of Tartu (UT). Nevertheless, the UT’s capacity and expertise still falls short of the leading institutions. At the same time, also the most competitive research groups face significant barriers to perform world-class science due to substantial networking gaps that still exist between previously non-linked research teams. TWINNING funding scheme is designed to overcome these aforementioned shortcomings. Thus UT has formed a WIDENLIFE consortium with its world-renowned partners: University of Oxford and Katholieke Universiteit Leuven, and altogether we have set two ambitious objectives to address. Firstly, for the UT: to become one of the leading research and teaching centres for reproductive and fetal medicine in Eastern and Northern Europe. Secondly, for all members of consortia: to intensify trilateral synergies between the research groups in the areas of female reproductive health and medicine. Our specific goals are to highlight the associations between female metabolic health and infertility, provide deeper understating for embryonal development, and offer new tools for infertility treatment and prenatal diagnostics. In order to resolve these objectives, exchange of know-how, ideas and information between the partners will be enhanced, creating the novel clinically valuable information through pooling the expertise and synergy of resources, interests and commitments by universities from Estonia, UK and Belgium. This could also mean a significant contribut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hydrological processes on late Mars: water under the telescope and under the microscope' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Mars displays clear evidence of water, having regions where water flowed at several times in its 4 billion years history. The aim of this fellowship is to reconstruct paleo-hydrological conditions on late Mars (from 3Ga to date) and to recreate the hydrogeological cycle that created the complex channel systems found on Mars’ surface. The stream tables, the Earth Simulation Lab and numerical modelling at the UU will allow for the first time: 1) to simulate frozen Martian subsoil characteristic and conditions; 2) to seek out signature of melting ice as sources up front of Martian river systems; 3) to investigate together the role of thermal and mechanical erosion. I will determine the lithological and fluid characteristics and their possible related deposits, water source triggering mechanisms, and will explain if it is by impact or spin axis / obliquity changes. High-resolution digital elevation modelling will be used to constrain hydrogeological parameters (under the telescope). Laboratory experiments and numerical modelling using a streamtable and an Earth Simulation Laboratory will support the core task (under the microscope). This research is urgently needed as it addresses key questions about past Martian habitability and its implications in subsurface degassing, potential landing site of future robotic/human missions and climate. The inter-disciplinary perspective adopted in this study, close integration of surface geology, analog modelling, and numerical modelling studies, will provide important new knowledge on the late Mars environment. The Experienced Researcher (ER) will work in the world-leading “River and delta morphodynamics group” group in the Department of Physical Geography at Utrecht University. The ER is already proving himself as a future leader: he h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of Salmonella Pathogenicity Islands in salmonellosis outbreaks and invasive disease' under Seventh Framework.

assistant: **Concept**

Non-typhoid Salmonella (NTS) enterica is a major cause of foodborne infections in industrialized countries and a leading cause of hospitalization and death among bacterial foodborne pathogens. The vast majority of the Salmonella virulence factors are encoded within horizontally acquired discrete regions along the chromosome known as Salmonella Pathogenicity Islands (SPIs). SPIs are crucial for Salmonella virulence. Herein we propose to study the role of 17 SPIs and associated virulence loci in different aspects of NTS pathogenicity including the ability to cause outbreaks, host-to-host transmission, and manifestation of invasive disease. In the first stage of the study we will map and characterize the distribution of these virulence loci across various outbreak and bacteremia isolates. This analysis will provide a broad view over the distribution of SPIs in highly virulence isolates, which are clinically relevant in Israel and Europe. Based the collected data, we will develop a Quantitative Microbial Risk Assessment approach for detection of virulent Salmonella strains in food, environmental and livestock samples. In addition we are interested in investigating the potential contribution of SPIs to the oral-fecal route of transmission. To do so, we will use the persistent mouse model and study the ability of Salmonella strains, harboring SPIs deletions to transmit the disease over time. The gained data are expected to yield a broader understanding about the role of primary virulence loci in the pathogenesis and epidemiology of Salmonella and will shed light on the evolution of pathogenic Salmonella serotypes. Understanding these mechanisms will contribute to our knowledge about host-pathogen interactions and the molecular basis of outbreaks. Deeper understanding about th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Viral metagenomics of human pathologies with unknown etiology'.

assistant: **Innovation**

While viral infections create an important threat for humanity, our knowledge of the viruses that infect humans is largely incomplete. So far, discovery of new viruses has been limited by the inability to propagate them in cell culture, the lack of serological cross-reactivity, or the absence of conserved genetic element to target by PCR. Thus, numerous acute and chronic diseases with unknown etiology are caused by yet unidentified viruses. Among the highest failure rates in determining the etiological cause of disease, pneumonia, encephalitis, and pericarditis are usually cited. In these cases, the search for unknown viruses is an urgent scientific task. We propose to identify new viruses, both indigenous and pathogenic, using metagenomics (shotgun Sanger sequencing and 454 pyrosequencing) of RNA and DNA from purified viral particles found in clinical samples of individuals presenting encephalitis, pneumonia, or pericarditis diseases without known etiology. Virus-centered bioinformatics methods will be developed to detect close as well as distant relatives of known viral species. Initial viral sequence similarity analysis will be followed by full viral genome reconstruction and phylogenetic analysis. The prevalence, abundance, and geographical distribution of newly identified viruses will then be determined using quantitative real-time PCR and RT-PCR on a 10-year collection of samples from extensively characterized patients.