RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ship Clones: Characterization and search for biomarker of marine transmissible cancers' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Ship Clones: Characterization and search for biomarker of marine transmissible cancers Clonally transmissible cancers are cell clones that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a disseminated neoplasia (DN) found in marine bivalves. DN is a leukemia-like cancer characterized by the proliferation of hypertrophied cells. In later stages of the disease, these cells spread throughout all tissues destroying their normal architecture and causing the death of their host organism. A polyphyletic origin of the DN has been detected in the common cockle Cerastoderma edule. DN has appeared on at least six different occasions and the six clones currently known coexist in cockle populations of the European Atlantic coast. In the present proposal high resolution lipidomics and proteomics will be used to screen for clonal biomarkers of DN and help to better understand the biological systems of transmissible cancers. Marine transmissible cancers are interesting biological models to better understand cancer transmissibility and metastasis. Marine clones likely ship using ocean currents to colonize new hosts in different regions. It is likely that they may also be unintentionally introduced by the action of man in disease-free regions. Hence, these cancers represent a potential threat for marine ecosystems, as they negatively impact keystone species (bivalves), that also have important socio-economic value for fisheries. As such, it is paramount to successfully identify, monitor and characterize the prevalence of clonal DN in marine bivalves, before any successful prevention and mitigation actions can be applied.


**Keywords:** Transmissible cance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Advanced simulations in electrocatalysis for efficient production of C3+ by carbon dioxide reduction'.

assistant: **Concept**

The climate change has raised concerns about closing the carbon cycle by converting CO2 and renewable electricity to chemically stored energy in the form of fuels and commodity chemicals. Among these, long-chain hydrocarbons and alcohols are more attractive because of their high energy density and value. Recently, reconstructed oxide-derived Cu (OD-Cu) catalysts have shown the potential to produce multicarbon species at lower overpotentials. However, few simulations have addressed the formation mechanism of these compounds due to the complex dynamics of this system under high currents, and the exact site for the excellent OD-Cu catalytic performance remains to be discovered. The DESCRIPTOR project aims to obtain the first generation of CO2 electroreduction catalyst with useful faradaic efficiencies towards C3+ products by employing computational simulations based on Density Functional Theory (DFT) and augmented by Machine Learning techniques. Firstly, suitable structures for the OD-Cu materials will be obtained through large scale Molecular Dynamics simulations based on Machine Learning potentials, by screening the most common ensembles identified via graph theory. Secondly, the mechanism towards C3+ will be identified via jDFTx scheme, and descriptors of activity and selectivity will be found through dimensionality reduction techniques. Finally, to assess and compare to experimental work from our collaborators, the contribution of the solvent/electrolyte and effect of experimental parameters will be investigated via ab initio Molecular Dynamics and microkinetic modelling. The structures will be characterized via simulations of X-ray Photoelectron Spectroscopy, and Raman spectra, etc. In summary, the outcome of DESCRIPTOR will have a direct scientific and social impact,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced Structure Preserving Lagrangian schemes for novel first order Hyperbolic Models: towards General Relativistic Astrophysics' (ALcHyMiA) targeting Horizon Europe.

assistant: **Abstract**

ALcHyMiA will make substantial progress in applied mathematics, targeting long-time stable and self-consistent simulations in general relativity and high energy density problems, via the development of new and effective structure preserving numerical methods with provable mathematical properties. We will devise innovative schemes for hyperbolic partial differential equations (PDE) which at the discrete level exactly preserve all the invariants of the continuous problem, such as equilibria, involutions and asymptotic limits. Next to fluids and magnetohydrodynamics, key for benchmarks and valuable applications on Earth, we target a new class of first order hyperbolic systems that unifies fluid and solid mechanics and gravity theory. This allows to study gravitational waves, binary neutron stars and accretion disks around black holes that require the coupled evolution of matter and spacetime. Here, high resolution and minimal dissipation at shocks and moving interfaces are crucial and will be achieved by groundbreaking direct Arbitrary-Lagrangian-Eulerian (ALE) methods on moving Voronoi meshes with changing topology. These are necessary to maintain optimal grid quality even when following rotating compact objects, complex shear flows or metric torsion. They also ensure rotational invariance, entropy stability and Galilean invariance in the Newtonian limit. The breakthrough of our new Finite Volume and Discontinuous Galerkin ALE schemes lies in the geometrical understanding and high order PDE integration over 4D spacetime manifolds. The high-risk high-gain challenge is the design of smart DG schemes with virtual, bound-preserving, genuinely nonlinear data-dependent function spaces, taking advantage of the Voronoi properties. Finally, it is an explicit mission of ALcHyMiA to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pole-ocean-pole: global stratigraphy for millennial climate variability (POP)'.

assistant: **Innovation**

POP will generate the data to place abrupt climatic events recorded in deep-sea sediments and ice cores from Greenland and Antarctic on a common time scale. This will be precise enough to allow cause-and-effects to be established. Over the Ocean, the North Atlantic, the area of the Indian monsoon, the Sub Antarctic and the Ocean Deep Water masses will be covered. We will generate temperature, nutrient and chemical proxy records. In ice cares we will deal with records of both the ice and the contained atmospheric gases. The time resolution in both, the marine and ice cores will be better than 200 years and will cover about 350 thousand years. We use modelling to optimise our temporal correlations, develop a common time scale and evaluate the implications of our results for climatic change. All data sets will be archived electronically. Findings will facilitate use of high-resolution palaeoclimatic records for understanding the climate system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthetic biology approach for the design of new-to-nature peptide-based antibiotic molecules' (PTM-FLEX), addressing dissemination and exploitation.

assistant: **Impact**

The rise of pathogenic bacteria that are resistant against a variety of antibiotic treatment emphasizes the need for novel active molecules. One promising novel class of active molecules is genetically encoded and ribosomally synthesized peptides, as they offer the potential to employ directed evolution approaches across a huge sequence space directly on an active substance in order to engineer novel activities and thus introduce a novel engineering principle into antibiotic development. However, in many cases the activity of the peptide molecule depends on substantial posttranslational modifications (PTMs) which give the peptides conformational stability and protect against proteolytic degradation. Consequently, the degrees of freedom in the engineering of such peptides on sequence level are highly dependent on the flexibility of the PTM-machinery to accept such changes. Here, we propose a synthetic biology approach to study systematically the flexibility of PTM-machineries for the class of lanthipepetides in order to assemble a highly flexible machinery that will support a broad range of engineering measures and thus optimize the chances to discover molecules with modified or completely novel activities. We also propose to implement a high-throughput screen for the bioactivity of these molecules in order to be able to engineer specific enzymes of the PTM-machinery for increased flexibility and to finally implement large scale directed evolution screens for novel antibiotic activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fpga als bildverarbeitungs-coprozessor mit bilddatenkornprimierung im low-level-bereich und cmos-bildsensor zum einsatz in der: uberwachungstechnik' (1998-2002).

assistant: **Innovation**

This project aims to develop an economical system of video supervision, 'which is built up modularly with the following technology applications:-image pick-up by means of CMOS sensor technology-FPGA as image processing coprocessor-Low-level image data compression (FPGA technology)-Low-power image processing with the option of self-sufficient photovoltaic supply-Fast image transmission to a standard PC or a supervisory centre. A combination of alarm system and video supervision shall be realised, based on the FPGA technology to a standard PC or a supervisor centre for a variety of applications, e.g. in the safety technology (for the benefit of police, fire brigade, army, security and watch offices, banks), In the form of security access and attendance control as well as for supervision tasks in the medical area (hospitals, clinical complex, geriatric care centres) , in industrial plants, traffic tunnels, avalanche areas, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel multifunctional cyclodextrin-based nanocarriers for drug encapsulation and delivery as a strategy to overcome current therapeutic drawbacks' (CYCLON).

assistant: **Concept**

There is a high demand for the development of new drug delivery strategies to combat major diseases in our society, particularly cancer. Current treatments are based on high efficacy drugs, however their non-selective uptake by both normal and tumor cells as well as the development of multidrug resistance (MDR), constitute major hurdles. Resistance is also associated with the use of nucleoside analogues as anticancer drugs in vivo. Photodynamic therapy (PDT), aims at selectively killing neoplastic lesions by the combined action of a photosensitizer and visible light. Passive targeting, involving enhanced permeability and retention effect, allows the accumulation of drugs on tumor sites, and concomitant active targeting with suitable functionalities, constitute properties currently associated with polymeric delivery systems. Cyclodextrins (CDs) are biocompatible and biodegradable oligosaccharide nanocages, known to improve the solubility, stability and bioavailability of drugs. Scattered literature reports incidents that CDs may constitute potential means to overcome certain forms of MDR, or to effectively deliver photosensitizing anticancer drugs preserving their photodynamic properties. This network, highly specialized in CD chemistry, photochemistry, in vitro drug evaluation and in vivo applications, proposes to synthesize diverse families of new CD derivatives to build a platform of CD-based drug delivery nanosystems with a variety of architectures. These new generation nanocarriers, encompassing many cavities in a nm-sized vehicle, will possess high drug loading capacity, improved permeability and retention effect, enhanced targeting and complete biocompatibility. Their mode of action will be assessed in vitro and in vivo. These goals will be achieved via a strong t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of ceramic coatings for the transgingival zone of dental implants and for knee prostheses' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

In the last two decades, the success rate of dental implants has been greatly enhanced by the use of materials, among which titanium, allowing a high degree of osseointegration. However, further improvements must be achieved in the transgingival zone, that is in the upper zone of the implant in contact with the oral soft tissues. This region is determinant for the perimucosal seal, which must prevent infection of soft and hard tissues around the implant It has been stated that the implant success possibly depends on the seal efficiency. Whereas titanium shows an excellent behaviour in the bone region, a smooth ceramic surface can provide a better soft tissue implant contact. It also decreases the rate of plaque build up and facilitates personal and professional hygiene procedures for plaque removal. Another advantage of ceramic materials is the possibility to produce them in a colour close to that of natural teeth. This greatly improves implant aesthetics, particularly in the case of gingival retraction commonly associated with dental implants. An improved dental implant could therefore be obtained by the combination of titanium and ceramic materials (titanium in the bone region, ceramic in the transgingival zone). It is proposed to achieve this combination by coating a ceramic layer locally on the transgingival area of the titanium implant. The objective of this project is to develop ceramic coatings on titanium implants by means of three different technologies (plasma spraying, PACVD and RF magnetron sputtering) and to assess the technical and biological performance of these coatings. Development of the deposition of ZrO2 and A1203 ceramics on titanium implants will be run simultaneously by the 3 coating partners. Deposition parameters will be optimised, so that the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Semantics for control with recursion' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Continuations provide access to the control flow in functional programming languages and therefore bring the power of jumps into functional programming. My goal is to give an appropriate semantics for this desirable language feature, where the language also has means to express general recursion, as do all general-purpose programming languages. The main challenge consists in considering continuations and recursion at the same time. There is growing evidence that certain categorical structures are appropriate for modelling languages with these features, which makes these structures the main focus of my research. Training content (objective, benefit and expected impact) I became interested in functional programming languages and semantics while I studied Informatics at the University of Erlangen. The Laboratory for Foundations of Computer Science in Edinburgh is an outstanding research institute in the area of semantics, as well as concurrency, applied category theory and more. As expected, I am profiting a lot from the available courses and discussions with leading researchers in my area of interest. Links with industry / industrial relevance (22) Industry has long term problems relating to the complexity of the definitions of programming languages currently in use. These definitions are long, unmanageable and open to divergent interpretations. This leads to incompatibilities across different implementations of the same language. The added cost to industry of these problems is significant and rising as languages become more complex. The work in this proposal aims to provide the basis for a uniform and modular account of a wide variety of programming language features. Eventually this work could have a significant impact on the definition a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multifunctional Immunocompatible NanoTheranostics to modulate tumor microenvironment and improve treatment monitoring: A double blow to pancreatic cancer' (MINT) under Horizon 2020.

assistant: **Objectives**

Different nanomaterials were developed so far in particular against cancer, paid very little attention to their potential immunogenicity, to their final destiny, as well as to the importance of zero-delivery in unwanted places. Thus, there is still a huge disproportion between the present nanomedicine tools and the clinical requirements. The ambitious purpose of the MINT project is to develop immunocompatible tumor targeted zinc oxide nanocrystals (ZnO-NCs) coated by extracellular vesicles (EVs) with enhanced drug delivery capabilities to cancer cells, by disturbing the supportive tumor microenvironment of pancreatic cancer, one of the most lethal human malignancies. Moreover, ZnO-NCs is doped with transition metal elements to be probed for treatment monitoring.In recent years while several therapeutic advances were implemented in many cancer types, the scenario of pancreatic cancer remains unchanged. The main factor behind the limited efficacy of chemotherapeutics in pancreatic cancer is its complex microenvironment. We propose to deliver Hedgehog pathway inhibitor & vascular endothelial growth factor receptor kinase inhibitor simultaneously through the multifunctional EV-coated doped ZnO-NCs to deplete tumor stroma, normalize tumor vascularity and improve pancreatic cancer therapeutic index. The proposed Fellowship will enable a highly interdisciplinary collaboration between the Researcher, experienced in targeted therapy & pancreatic cancer biology, and the supervisor, pioneer in designing nanotheranostics. These working conditions will effectively promote the Researcher’s professional development, providing her with excellent new expertise in nanotheranostics and fundamental leadership skills, significantly widening her career perspectives. The project outcomes will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Standardization related to Research and Development for Nanotechnologies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The aims of the project are; to develop a road map of the European standardisation and pre-normative research work for nanotechnologies and to enable Europe to internationally play an active role in standardisation and nanotechnologies.The objectives are to:-Facilitate European industrial development and exploitation-Enhance integration between research and production fields-Address the different aspects of industrial and consumer health and safety-Provide appropriate organisations and structures with information about the needs of the different stakeholders.The project will foster collaboration between national ministries, European and International standardization bodies, European research organisations and industries in numerous nanotechnology sectors. A consortium composed of seven national organisations with complementary skills will deliver the project.A wide range of other organisations will also contribute, including an advisory committee, composed of several European and international experts will review and advise on project progress, a number of stakeholders will attend project workshops to assess industry needs and offer potential solutions and 2,500 selected organisations will be invited to respond a pan-European questionnaire. This inclusive and consultative approach will provide a conduit through which experts, other interested parties and European industries and citizens will influence drafting process of the global standards.The project management and decision making process will ensure that the consortium satisfies the aims of the study, implements the work plan effectively, meets agrees milestones, reports progress and produces comprehensive and current technology roadmaps. To consolidate and widen the potential impact of the project, knowledge develo