RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Between a Rock and a Hard Place: context, function and choice  of early metalworking tools on Europe’s Atlantic façade'.

assistant: **Concept**

The aim of this project is to achieve a better understanding of both the technological and the social dimensions of early metalworking in Western Europe, through a systematic study of the toolkit employed by Chalcolithic and Bronze Age craftspeople. The study will consider both physical (tool morphology, use wear, material properties) and contextual data (site type, chronology, association with other items), with the primary objectives of reconstructing the respective chaînes opératoires and of identifying inherent constraints and determinants in metalworkers’ technical decision making. The latter will also involve a systematic comparison between the types of rock chosen as raw material for lithic metalworking tools and raw-material selection for other lithic implements within their respective communities, to gain insights into the structure of metalworkers’ social networks.The corpus of material to be included in this study comprises the vast majority of known percussive metalworking tools (hammers and anvils) from Western Europe, manufactured both from lithic materials (c 330 objects) and from copper-base alloys (c 180 objects). The study area includes the British Isles, France, the Iberian Peninsula, and the Benelux countries, with chronological coverage extending to the onset of the Iron Age in the early 1st millennium BC.The project’s methodology builds on a novel approach developed by the fellow as part of her PhD work on lithic metalworking tools from France, but will also introduce a number of new approaches (lithics provenancing, network analysis), considerably expanding and diversifying the fellow’s skill base (artefact petrology, 3D scanning, database design), to ultimately allow her to attain a position of professional maturity at an international level. Pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'HELIOS: A Context-aware Distributed Social Networking Framework'.

assistant: **Innovation**

The HELIOS project will design, implement and validate a state-of-the-art, peer-to-peer federated social media network that addresses the dynamic nature of human communications in three dimensions- contextual, spatial and temporal- while providing all necessary means to ensure the highest level of trust and privacy.   HELIOS implements a user-friendly solution for creating and managing social networks. Its core scope is to facilitate democratization of content production, promotion and monetization. HELIOS will also reduce development cost and deployment complexity of any social media application built on top of it.   Implemented technologies and tools are following a modular strategy which ensures continuous development beyond the scope of the project, yet maintaining basic features of security and robustness.  As a unique value proposition, the project will overcome the closed ecosystem stigma and will re-define the term “social media platform” by creating a foundation for co-operating social networking services. The novel distributed context-layered model in which different types of services (private and public) can form symbiotic existence.


**Keywords:** context-aware networking, decentralized architecture, meaningful interactions, heterogeneous network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bioengineered Matrices Mimicking the Lung Tumor Microenvironment' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Lung cancer is the leading cause of cancer-related mortality in the world. It most often gets diagnosed at an advanced stage with a 5-year survival rate as low as 5%. Despite recent advances in development of therapeutics, lack of a comprehensive understanding of the complexity and dynamicity of the tumor microenvironment hinders effective clinical outcome. Tumor microenvironment plays a crucial role in tumorigenesis and subsequent disease progression leading to metastasis as well as resistance to therapeutics. Conventional monolayer culturing of tumor cells fails to recapitulate the essential microenvironmental aspects of native tumors whereas mouse models suffer from limited relevance, high cost and low throughput. A three-dimensional (3D) human in vitro tumor model that faithfully mimics the tumor microenvironment is key to advance the current understanding of biological processes and signaling pathways that govern these complex pathological events. I propose a biomimetic human lung tumor model that allows independent tunability and control of aberrant biochemical and mechanical aspects of the tumor microenvironment to study cellular events that govern tumorigenesis (Objective1), metastasis and drug resistance (Objective2) and patient heterogeneity (Objective3). Following a highly interdisciplinary approach where tissue engineering, material science, medicine and molecular biology converges, the implications of a tunable and biomimetic 3D human tumor model is substantial for the future of precision-medicine and development of patient- specific therapeutic regimens.


**Keywords:** Cancer tissue engineering, biomimetic materials, tumor microenvironment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Selenium-based Targeted Nanocapsules to treat Breast Cancer' under Horizon 2020.

assistant: **Concept**

The European Chronic Diseases Alliance has defined cancer as one of the major non-communicable diseases, accountingfor 13% of the deaths worldwide, resulting in 8.2 million deaths annually. In the NEOSETAC project, breast cancer will be thefocus of study being the most common cancers in women. It comprises of 10.4% of all the cancer incidences among women,causing 411 093 deaths per year overall the world. In Europe, there is more than twice of the amount of new breast cancercases annually than new cases of cancer in any other place. The complexity of breast cancer makes it a big challenge forsuccessful treatment. The NEOSETAC project will demonstrate the anti-cancer therapeutic potential of a novel Seleniumbasedtherapy for the management of breast cancer. The clinical application of Selenium (Se) compounds for cancertreatment is until now limited in chemoprevention as dietary supplement. In this proposal, we aim to improve the therapeuticwindow, pharmacokinetic properties and targeting drug delivery via nanoparticles (NPs). By loading Se into biodegradableNPs, drug release is controlled within the narrow therapeutic window of Se. At the same time the uptake and activation of Secompounds at desired location (tumor lesions and metastasis) is achieved. We also propose to functionalize NPs by cancercell / cancer stem cell targeting ligands to further improve the therapeutic efficacy and prevent cancer recurrence afterchemotherapy. These advantages will lead to an enhanced anticancer activity and reduced systemic toxicity. Moreover,targeting via NPs will improve the pharmacokinetic properties and increase the relatively short half-life (~18 hours) of Se.


**Keywords:** breast cancer, specific drug targeting,  Selenium-based therapy,  intracellular oxidative stress, induced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MULTISCALE APPROACH TO THE IDENTIFICATION OF MOLECULAR BIOMARKERS IN ACUTE HEART FAILURE INDUCED BY SHOCK' to be submitted under Seventh Framework.

assistant: **Abstract**

The management of cardiovascular stability in shock patients is of paramount importance in critical care. New, cutting edge knowledge is necessary to overcome the shortcomings of available therapies, in order to cope with the challenges that anesthesiologists, intensive care specialists and emergency physicians face when dealing with shock patients.Current therapies are targeted to reduce symptoms of shock and multiple organ failure, but they are unable to target the root cause or to act at the “beginning of the cascade”, because of the lack of a model explaining the molecular basis of shock induced tissue injury and ensuing multiple organ failure. Hence, the effectiveness of anti-hypotensive interventions such as fluid resuscitation is limited. Fluid may restore blood pressure within minutes, but complications such as pulmonary edema may arise on a longer time scale in patients who are unresponsive to fluid infusion, and cause more severe stress to the patient’s hemodynamic stability, respiratory efficiency, and immune system.This proposal seeks to shed light on the molecular trigger of acute heart failure in association to shock, in the presence of uncontrolled proteolytic activity, in order to identify inflammatory mediators and markers which are activated in shock, through a systematic analysis of expression levels of genes and their protein products, and novel targets for the delivery of new therapies, necessary to overcome the limitations of current ones.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protection of the Environment from Ionising Radiation in a Regulatory Context', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The need for a system to protect the environment from ionising radiation is now generally recognised and there has been a considerable international and national effort on this issue over the last decade. The focus has been on collating relevant information and developing approaches to enable regulatory assessments. Alongside this, there has been extensive consultation with stakeholders. Validation and comparison of the radioecological and dosimetry components of various approaches has begun. However, it is important that the approaches used are practicable, credible to stakeholders and appropriate to use in any future regulatory context. Concerns have been expressed both from some members of the nuclear industry and the scientific community that the developing approaches may lead to costly regulation. To evaluate the practicability and relative merits of different approaches to protection of the environment from ionising radiation and to compare these with methods used for non-radioactive contaminants the co-ordination action will: i) Consult within Europe and the broader international community with industry and regulators to review regulatory instruments, procedures, underlying principles and criteria currently applied to environmental protection from both chemical and radioactive substances. A critical review will identify similarities and differences in approaches for chemicals and radioactive substances, evaluating the extent to which these fulfil the objectives of environmental protection. ii) Comparatively evaluate the existing/developing approaches to assess their practicability in a regulatory context, assessing their relative merits in terms of complexity, fitness for purpose, cost and robustness. iii) Consider appropriate numerical benchmark values, designed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Interactive Analysis, Simulation and Visualisation Tools for Urban Agile Policy Implementation'.

assistant: **Concept**

In the context of European initiatives to improve policy as a more transparent and understandable process, the urbanAPI project aims to support activities such as issue identification, policy analysis, consultation, decision and evaluation in urban planning and land management policy. For this purpose, a policy metamodel, a formalised vocabulary, a set of rule languages to define data integration and abstract simulation models are introduced. Furthermore, the urbanAPI approach will transpose elements of agile ICT development to the urban policy making process: Multiple activities can run in parallel, and all activities are kept synchronized. In such a process, risks are identified earlier, conflicts are understood better, and that knowledge gained in one activity can directly be used in all other activities.On this formal basis, a novel ICT toolset is developed. The urbanAPI toolset allows the fast development and deployment of participative policy support applications. These applications can be used for decision support, conflict management, analysis and visualisation and rely on innovative interaction platforms. Concepts known from web 2.0 and semantic web technologies, such as linking, tagging, rating and adding of semantic annotations, are supported directly. Applications created with the urbanAPI toolset also make use of a comprehensive data integration system to make use of the vast data resources – geospatial and statistical datasets – related to planning.Local initiatives in the four urban regions working in this project will be encouraged to participate within the planning process, to contribute to the final solutions and understand and finally accept the expected impacts on environment and habitants. Based on the toolset, adapted urban planning applications wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mixotrophy in marine microalgae for renewable biomass production' under Horizon 2020.

assistant: **Concept**

Diatoms are unicellular eukaryotic algae (microalgae) and one of the most common and diverse type of marine phytoplankton. Thanks to a flexible cell metabolism, they dominate in environmental conditions normally unfavorable for photosynthesis, i.e. freezing seawater, low light intensity and short photoperiod. Moreover, diatoms are able to synthesize storage lipids (20-50% of cell dry weight) that can be used for production of renewable biomass and high-value fatty acids. However, the success of these microalgae as feedstock depends on lowering the production cost. The proposed project aims to develop mixotrophic cultivation (i.e. the simultaneous use of light and carbon dioxide for photosynthesis and organic carbon for respiration) to maximize growth and outdoor productivity for selected strains from the Swedish west coast. The focus will be on the bloom-forming coastal diatom Skeletonema marinoi (S. marinoi) whose sequence annotation is ongoing, and the recent knowledge on mixotrophic growth of the model diatom Phaeodactylum tricornutum will be employed. The main objectives will be: i) using the bloom-forming S. marinoi to better understand mixotrophic metabolism in diatoms; ii) exploring the optimal mixotrophic conditions for enhanced productivity of S. marinoi; iii) investigating the potential industrial applications of S. marinoi when cultivated under mixotrophy. To achieve these objectives, an interdisciplinary approach including computational, biophysical, analytical, biotechnological and biological methods will be employed. A mixotrophic outdoor cultivation of marine microalgae in the dynamic climate of the Swedish west coast could provide a higher total production of renewable biomass for industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Preparing multi-actor projects in a co-creative way' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Societal Challenges addressed by European Union (EU) strategies such as the Green Deal and Farm-to-Form require innovative solutions in agriculture, forestry and rural areas. The Multi-Actor-Approach (MAA) is a promising instrument to speed up innovation. However, the H2020 RIA LIAISON (2018-2022) has identified some deficits and inconsistencies in the interpretation of the MAA by both current and potential MA consortia and Member States’ (MS) authorities. PREMIERE will therefore foster the development of sound, coherent and well-prepared MA projects in two ways. Firstly, it will contribute to the building of project consortia that make best use of the complementary knowledge of their members during proposal writing, project activities and beyond, in particular by improving the connection between Horizon Europe (HE) MA projects and Operational Groups (OG). Secondly, through insights and tools, it will support the implementation of innovative governance and sound decision making in policy and administration for the green transition. By using the results from LIAISON and capturing ‘grass roots’ ideas from project participants, policy makers and executive agencies through stakeholder dialogue across all 27 EU MS (including with the SCAR AKIS SWG, National Contact Points and other relevant HE projects), PREMIERE will develop tools as well as training and networking events for capacity development. These will include a Serious Game, an Online Academy and a MOOC. The project will test out the effect of providing seed funding to at least eight MA organisations (mainly OGs) and prepare a handbook of good practices. This user-focused workplan, with its open science outputs, will lead to more effective EU and national AKIS. It will be implemented by a very experienced, compet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Normalisation of immune reactivity in old age – from basic mechanisms to clinical application'.

assistant: **Concept**

When restoration of the immune response in older age is the target of basic and clinical research, boosting innate and adaptive immunity, e.g. by more efficient vaccination strategies, is the general approach. However, TOLERAGE has a fundamentally different focus, i.e. restoring the age-dependent decline of auto-tolerance that underlies the development of the paradigmatic age-associated diseases atherosclerosis (AS) and rheumatoid arthritis (RA). These diseases represent the major medical and socioeconomic burden in aging societies. They start earlier in life but become clinically manifest with increasing age. To reach this aim a consortium of ten partner groups was formed that have an outstanding track record in areas of immunology pertinent for this task. The work of TOLERAGE will focus on three major issues, viz. 1. Investigating basic principles of the induction of central and peripheral tolerance in mice against autoantigens, including heat shock protein 60 (HSP60) that has been shown to play a major role in the development of AS and RA. 2. Determination of the mediators of central and peripheral tolerance that are responsible for the T effector/T regulatory cell dysbalance in older age in general and in AS and RA in particular. 3. Translation of the results obtained in (a) and (b) into practical application for the prevention and treatment of AS and RA by appropriate vaccines. For all partners, important technical platforms will be available, including unique transgenic and knockout mouse strains, sophisticated models for in vitro and in vivo transfection of dendritic cells (DCs) and a well established Functional Genomics Facility.