RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optogenetic Protein Therapy for Multiple Sclerosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Optogenerapy proposes a new interferon-ß (IFN-ß) drug delivery system to revolutionize Multiple Sclerosis treatment.The aim is to develop and validate a new bio-electronic cell based implant device to be implanted subcutaneously providing controlled drug release during at least 6 months. The cell confinement within a chamber sealed by a porous membrane allows the device to be easily implanted or removed. At the same time, this membrane acts to prevent immune rejection and offers long-term safety in drug release while overcoming the adverse effects of current cellular therapies. Wireless powered optogenetics – light controlling the cellular response of genetically engineered cells – is used to control the production of IFN-ß.Replacing standard intravenous IFN-ß delivery by subcutaneous delivery prevents short and long term side effects and efficiency-losses related to drug peaks and discontinuation, while saving non-adherence costs.It is a low-cost system enabling large scale manufacturing and reduction of time to market up to 30% compared to other cell therapies, combining:- Polymeric biomaterials with strong optical, biocompatibility and barrier requirements, to build the cell chamber and to encapsulate the optoelectronics.- Optoelectronics miniaturization, autonomy and optical performance.- Optimal cellular engineering design, enhanced by computer modelling, for stability and performance of the synthetic optogenetic gene pathway over long-term implantation.- Micro moulding enabling optoelectronics and membrane embedding for safety and minimal invasiveness.The innovation potential is so huge that a proof-of-concept was listed by Scientist Magazine as one of the 2014’s big advances in science.In our top-class consortium, industrial pull meets technological push, ensurin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MULTI-LEVEL PROTECTION OF MATERIALS FOR VEHICLES BY “SMART” NANOCONTAINERS', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project MUST will provide new technologies based on active multi-level protective systems for future vehicle materials. “Smart” release nanocontainers will be developed and incorporated in commercial paints, lacquers and adhesive systems to prepare new products exhibiting self-healing properties. A multi-level self-healing approach will combine - in a same system - several damage prevention and reparation mechanisms, which will be activated in response to environmental conditions. The main objective of the project will cover design, development, testing and application of coated materials and adhesives used as novel multi-level protection systems for future vehicles. The new active protection systems will be based on different types of “smart” nanocontainers incorporated in polymer matrixes and adapted to the level of protection. These systems will result in a radical improvement of the long-term performance of metallic or polymer substrates. To achieve the objectives, MUST has been configured in four main activities (WP): WP2 is divided in 6 sub-projects (SP) where SP1 is technology-oriented, and concerns the production of nanocontainers.SP2 and SP3 are directed to basic research, and consider fundamental studies on self-healing mechanisms and development of simulation models. SP4, 5 and 6 consider exploitation, costs and upscaling of the most promising systems in automotive, aerospace and maritime sectors, respectively. The demonstration of the technologies will be performed together with continuous risk management in WP3. WP4 also will manage dissemination of the results and training activities and WP1 will consider the whole coordination of the project. MUST will increase considerably the life cycle of materials and therefore boost the competitive strength of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project '3rd European Conference on Computational Chemistry'.

assistant: **Objectives**

The European Conference on Computational Chemistry is the official conference of the Working Party of Computational Chemistry (WPCC) of the federation of European Chemical societies. The first meeting (ECCC-1) was held in Nancy, France (1994), the second one (EUCO-CC2) in Lisbon, Portugal (1997). On the basis of the big success of these conferences (each time about 200-300 participants from all over Europe) WPCC decided to organise the next meeting (EUCO-CC3) in Budapest. Computational chemistry is an interdisciplinary field, encompassing the application of computational methods to problems related to molecular phenomena. It spreads over many areas of chemistry, molecular biology and materials, as well as over computer science.In the last fifteen years computational chemistry enjoyed such a significant development that computational chemistry laboratories have been established in practically all multinational chemical and pharmaceutical companies in order to provide a sound basis for the development of new materials, drugs, diagnostics, engineered proteins, polymers, catalysts and specific chemicals. In accord with these, the main goal of the EUCO-CC conferences (and the WP itself) is to give an opportunity of researchers working on different fields of computational chemistry to compare their methods and be drawn towards new co-operations. Thus, the focal points of the conference cover most important areas of computational chemistry: Methodology - a survey on recent developments in methodology and software; Structure and reactivity - organic reactions, radical reaction and molecular systems, models of various systems in the condensed phase; Biopolymers and Drug Design - a field where computational chemistry brought spectacular success.ftp://ftp.cordis.lu/pub/improving/d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Small open reading frames (smORF) as novel modulators of disorders of dietary excess'.

assistant: **Objectives**

Dietary excess is the major origin of cardiovascular diseases and remains the leading cause of mortality. Due to difficulties with bioinformatics detection and experimental analysis, along with their sheer numbers, small open reading frames (smORF) –of fewer than 100 amino acids– have been largely disregarded. Advances in bioinformatics, RNA-sequencing (ribosome profiling), biochemical (peptidomics) and functional (genetic) screens, suggest that a large amount of smORF are transcribed and sometimes widely conserved. However, how much of these smORF-encoded peptides or small proteins (microproteins (MPs)) are translated into a functional peptide is largely unknown. Moreover, whether food bioactive components modulate the expression of MPs remains complete obscure. Thus, the main goal of this project is to search for MPs that regulate lipid metabolism in the intestine in response to dietary excess. The intellectual merits of this proposal are threefold. First, it will use cutting-edge technology to search for novel functional MPs. Second, it will address a new group of novel potential players not previously addressed in lipid metabolism, providing a novel insight into disease mechanism and innovative therapeutic strategies. Last, by testing two common food bioactive components from our healthy Mediterranean diet, we will open up a completely new field of research in the area of nutrition and health. The research approach will involve (i) a genome-wide peptidomic screen and ribosome profiling analysis of lipid-induced intestinal MPs, (ii) the use of in vivo and in vitro biochemical approximations to validate the function of the selected intestinal peptide, and (iii) the use of dietary components hydroxytyrosol and the omega-3 polyunsaturated fatty acid DHA as proof of conc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CLASSIFICATION OF EUROPEAN BIOMASS POTENTIAL FOR BIOENERGY USING TERRESTRIAL AND EARTH OBSERVATIONS' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The main objective of the project is to develop a common methodology for gathering information on biomass potential using terrestrial and earth observations. This objective will be achieved by the implementation of a systematic assessment work plan and will result in the establishment of a harmonised approach and an e-training tool for dissemination. The e-training environment will be an important tool for reaching the much-needed European harmonisation, whereas a Stakeholder Platform will facilitate access to reliable and common datasets on biomass potential and as such it will offer a more efficient use of the available European biomass feedstock.  The project will: - Develop a common methodology for gathering information on biomass potential using terrestrial and earth observations - Use e-technologies for disseminating information, best practices on the use and applicability of developed harmonised methodology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Logistices to support continuous improvement for SMES in the virtual enterprise' under Fourth Framework.

assistant: **Concept**

The principal objective of LOGSME is to provide information systems to integrate supply chain operations from sales through distribution, production and purchasing. The goal of this logistics system is to continuously monitor and improve performance across the supply chain by establishing control of the elements of the supply chain so as to optimise its cost effectiveness, performance and timeliness.LOGSME will develop a number of major prototype elements including tools for planning and control, tools for linking solutions and legacy systems and communication tools to facilitate improvement for the SME who forms part of a virtual enterprise. In addition a number of manufacturing modules will be modified for a seamless toolset together with the major prototypes.LOGSME will focus on developing low cost PC based tools which integrate to existing systems and tools. Market standard development tools and platforms will be adopted to ensure a wide market take up of the project results. LOGSME will make use of a rapid prototype development approach which will see early 'throw-away' prototypes developed to demonstrate initial concepts and presentation styles. The end user partners will participate in the definition of requirements through the evaluation of these prototypes which will replace 'paper designs' to a large extent.The potential for LOGSME is high with particular impact on the food sector in the short term, but long term for the entire European SME community. With LOGSME, SMEs will be able to gain greater benefits from forging close ties to their suppliers and customers to form virtual enterprises, and by the sharing of information continually improve their response to market requirements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel mitotic signalling pathway composed by the NIMA family protein kinases Nercc1, Nek6 and Nek7. Regulation, functions, and possible implication in cellular transformation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

It is proposed to study a novel mammalian signalling pathway composed of the NIMA-family protein kinases Nercc1/Nek9, Nek6 and Nek7. Neks are related to NIMA, an Aspergillus kinase required for mitotic entry, and are involved in chromatin condensation and formation of the spindle. Nercc1 was identified as a human Nek that binds, phosphorylates and activates two members of the same family, the homologous Nek6 and Nek7.Nercc1 is active at the centrosomes and spindle poles during mitosis, and interference with the kinase function results in spindle abnormalities and incorrect chromosome alignment, resulting in prometaphase arrest or abnormal chromosome segregation and aneuploidy. It is proposed to study the regulation of the Nercc1/Nek6/7 signalling cassette, as well as to identify substrates of these kinases and determine their role during mitosis and the formation of the spindle. I will seek to determine the mechanism that keeps Nercc1 inactive in interphase and activates it in mitosis, as well as to identify Nercc1 and Nek6/7 binding partners.The role of the kinases during mitosis will be studied through the use of different inhibiting strategies, including the production of knockout cells and mice. The goal of this proposal is to understand the position of the Nercc1/Nek6/7 pathway in the midst of different signalling pathways that control and execute mitosis, to determine whether its deregulation may be involved in cellular transformation through contribution to genetic instability, and to identify Nercc1 inhibitors and assess them as therapeutic anti-mitotic drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Strategies for financial integration with stronger social cohesion and democratic control in Europe'.

assistant: **Innovation**

A sustained and integrated assessment of the current financial changes in Europe and of their social significance. The emphasis of our study will be on developing an integrated, account of the financial changes resulting from both global forces and monetary union; and on analysing the dangers and opportunities these changes represent for the European social models . Results will be formulated in terms of strategies aimed at combining financial integration with social cohesion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A mobile heat trearment process for pest control', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

With the clear agenda set for the phase-out of Methyl Bromide by the 7th Gonference of the Parties to the Montreal Protocol in Vienna in December 1995 the food processing industry has now been confronted with the urgent need to find replacement insect pest control methods to comply with the increasingly stringent health and safety regulations for their production sites as well as for pest controllers in general. The research partners, Thermo Lignum GmbH of Germany, FTD-Entwicklungs- und Service Ges. m.b.H. of Austria, Igrox Limited and Thermo Lignum UK Limited of the United Kingdom understand that there is currently no viable and cost-effective method for the treatment of food processing facilities like flour mills and bakeries, nor for any food processing machinery, bins, silos and other facilities for the treatment of commodities in storage, like cocoa beans and coffee. Their objective therefore is to investigate the feasibility of utilising currently exist static chamber-based technology incorporating novel heat and humidity control to kill insect pests in furniture, artefacts and organic material in general to the field of public health and food storage and production as a possible alternative to the use of the ozone-depletant Methyl Bromide in this sector. With the clear agenda set for the phase-out of Methyl Bromide by the 7th Conference of the Parties to the Montreal Protocol in Vienna in December 1995 the food processing industry has now been confronted with the urgent need to find replacement insect pest control methods to comply with the increasingly stringent health and safety regulations for their production sites as well as for pest controllers in general. The research partners, Thermo Lignum GmbH of Germany, FTD-Entwicklungs- und Service Ges. m.b.H. of Aus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Satellite-UMTS IP-based Network' (SATIN).

assistant: **Concept**

Project SATIN aims to investigate several new Satellite UMTS architectures that provide a range of new and complimentary packet based services to the terrestrial component of the UMTS. SATIN provides a fresh view as to the role of satellites within the overall UMTS design by focusing attention of using the satellite component as an effective and efficient access network for delivery of a wide range of packet-based and point-to-multipoint services. Based on the above architecture, SATIN will produce an optimised layer-1 and layer-2 design with full integration into the terrestrial UMTS core network in mind.Objectives:Efficient support of Internet-based applications to mobile/nomadic users is a key feature of the 3G Networks. In light of the shortages and the high cost of the T-UMTS spectrum, the operators are looking into provision of integrated broadcast/multicast services through hybrid broadcast-UMTS systems. S-UMTS could play an important role in efficient delivery of some UMTS services to which it is better suited. These services include broadcasting & multicasting applications such as audio/video, e-newspaper, live stock exchange data, etc.In doing so, SATIN will follow three main objectives:1-Introduction of new packet-based S-UMTS architecture as an integral part of the UMTS.2-Definition and optimisation of the packet mode S-UMTS layers 1 & 2.3-Active participation and contribution to the standardisation in particular the ETSI & the 3GPP.Work description:Project SATIN is an in-depth research and technology project. During the course of the project a number of new packet-based S-UMTS architectures would be studied. The requirements placed up on the S-UMTS access network by the UMTS core network will be considered paving the way for full integration with the T-UMTS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A mouse model to study the expression and potential role of tcf11'.

assistant: **Innovation**

Summary TCF 11, a human bZIP transcription factor, has recently been cloned, mapped and characterised in the laboratory of Professor Kolsto. We propose to discover the role of this novel transcription factor by studying its homologue in the mouse. Genomic and cDNA clones homologous to the human TCF11 gene will be isolated and characterised by screening the relevant mouse libraries. The mouse gene, TCfl I will be mapped by linkage analysis to see if it corresponses to any mouse mutations which are models of human genetic disease. Tcf11 expression will be examined in the adult mouse by analysis of Northern blots and throughout embryonic development by in situ hybridisation of Tcf11 RNA to whole mount embryos. The effects of null or over expression of Tcf11 will be studied by generating transgenic mice carrying null or multiple copies of the gene.