RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Is the succinate/SUCNR1 axis a fulcrum of cellular clocks?' (CIRCASUC) targeting Horizon Europe.

assistant: **Abstract**

Our circadian clock controls a wide range of physiological processes to respond to external demands through a fine-tuning coordination between the hypothalamic central clock and the peripheral clocks. Understanding the bidirectional communication and the reliance on external cues that specifically affect these clocks is of paramount importance. Yet, both circadian clocks can function even in the absence of these external signals, highlighting their endogenous nature. This underscores the existence of endogenous signals such as metabolites and other biomolecules that can modulate the circadian clocks. Surprisingly, this aspect remains largely unexplored in current research.Succinate is both an energetic metabolic product of mitochondrial activity and a byproduct of the microbiota, with critical physiological roles in cellular function at various levels. Furthermore, in the last years, succinate is emerging as a biomarker for early detection of metabolic dysfunction and cardiovascular risk. As a basis for the current proposal, we have recently reported, via an untargeted approach, that succinate regulates core-clock genes in adipocytes via its cognate receptor, SUCNR1. Thus, building upon our previous studies, we propose that succinate may serve as a pivotal endogenous signal capable of modulating the circadian clocks.Within the framework of this project, we present for the first time the concept of succinate as a link between metabolism and circadian clocks. To accomplish our goals, we will employ the complementary expertise between Dr Fernández-Veledo (supervisor and renowned expert in the succinate/SUCNR1 axis) and Dr Ribas (candidate and expert in chronobiology). By merging these two fields, we aim to integrate the notion of temporality into the succinate/SUCNR1 axis,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanisms regulating pulmonary neuroendocrine cell (PNEC) growth and tumorigenesis' (PNEC).

assistant: **Innovation**

The ultimate goal of my research is to elucidate pathways involved in lung neuroendocrine tumor (LNET) formation. LNETs arise from a rare lung cell population, called pulmonary neuroendocrine cells (PNECs) and account for 20- to 25% of all lung cancers. Despite their involvement in LNETs and a number of other respiratory diseases, relatively little is known about the normal function of PNECs or their contribution to cancer development and progression. Utilizing a novel organoid based strategy for in vitro isolation and analysis of PNECs, I will develop a model of LNE tumorigenesis with a focus on two LNET subtypes, small cell lung cancer (SCLC) and atypical carcinoids (AC). Altogether, the experiments outlined in this proposal are focused on the functional characterization of PNECs and the elucidation of the pathways involved in the transformation of this cell type during LNET formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of the plasminogen-plasmin system following experimental focal cerebral ischemia' (1998-2002).

assistant: **Concept**

Micro vascular integrity is crucial for secondary brain damage, especially for oedema and haemorrhage. In a mouse model of focal cerebral schema effects of various knockout genes (u-PA, t-PA, PAI-1) on the micro vascular damage are examined by immunohistochemistry, western-blot and laser co focal microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Testing the paradigm of a single plastid origin in eukaryotes' in the context of a Horizon Europe call.

assistant: **Objectives**

Photosynthesis was acquired by eukaryotes through endosymbiosis with cyanobacteria, which resulted in new cellular organelles: the plastids. From the origin of plastids evolved the first eukaryotic algae, giving rise to land plants but also triggering the evolution of most photosynthetic eukaryotes by subsequent endosymbioses between these first algae and other eukaryotes. Thus, the origin of plastids profoundly changed the course of eukaryotic life by being the launching point that shaped the biological diversity of most primary producers. Despite this importance, our understanding of how plastids originated remains largely uncertain. The current paradigm describes this transformative event as a single primary endosymbiosis, but I argue here that critical data is lacking, notably from the vast hidden environmental diversity of microbes, to adequately test this hypothesis. In this project, I propose to gain insight into the origin of plastids by addressing the main questions: 1) What is the currently hidden diversity of high-ranked taxa related to primary photosynthetic lineages? 2) What are the feeding behaviors of these taxa and are they aplastidic? 3) Are some lineages genetically predisposed to establish plastids from the acquisition of foreign genes? 4) What was the composition, size, and origin of the ancestral primary plastid proteomes? To answer these questions, I will link third generation environmental sequencing, transcriptomics, and genomics to cell structure and behavior of novel key lineages related to primary algae, and produce crucially missing plastid proteomes to allow comprehensive comparative proteomic analysis. My project will not only have immediate implications on our understanding of the origin of plastids and more generally the fundamental proce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Stable carbon isotope ratios for the identification of environmentally significant halomethanes'.

assistant: **Concept**

Carbon isotope signatures for halomethanes from several environmental samples will be detonated using continuous flow gas chromatography - mass spectrometry - isotope ratio mass spectrometry methods. Our aim will be to identify soil sources of halomethanes in the environment and assign them typical carbon isotope signatures and then compare them with those measured for halomethanes from other known sources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Desertification and regeneration : modelling the impact of market reforms on central asian rangelands' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective of this project is to contribute to policies that promote environmentally sustainable and profitable pastoral livestock industries in Kazakhstan and Turkmenistan. To achieve this goal, remote-sensed data will be used to identify desertification patterns at selected study sites. Satellite-based environmental assessments will be combined with inter-disciplinary field studies that show why grazing systems are changing and how these changes affect desertification processes. Results of these studies will be integrated into a model that predicts how pastoral households will respond to changes in government policy, shifts in market prices or fluctuations in stock numbers. The model will be used to forecast the environmental impact of alternative policies and to identify improved husbandry practices for private flock operators. Results will be disseminated to national policy makers, international donor agencies, and representatives of local producer groups. Training and material support provided by the project will improve the capacity of Central Asian research institutes to conduct similar work in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Holistic Human Factors and System Design of Adaptive Cooperative Human-Machine Systems' (HOLIDES).

assistant: **Concept**

HoliDes addresses development and qualification of Adaptive Cooperative Human-Machine Sys-tems (AdCoS) where many humans and many machines act together, cooperatively, in a highly adaptive way. They adapt to each other and to the context to guarantee fluent and cooperative task achievement. Such systems with higher levels of automation are urgently needed to enhance safety and to increase the confidence of human operators. However, adaptiveness in Cooperative Human-Machine Systems on the Health, Aeronautics, Control Rooms and Automotive market is still sadly limited. The development and especially the qualification and certification of AdCoS in-volving several interactive Embedded Systems are not yet well-mastered in industrial develop-ment. The lack of adequate means of compliance with human factors and safety regulations may force the designers to simplify systems in order to make them certifiable. This clearly compromises the huge potential AdCoS could have on increasing overall safety. In order to unleash this potential HoliDes will research affordable means of compliance which enable to formalize adaptation strategies on global many humans - many machines levels and local HMI levels in a coordinated way. This will be achieved by developing techniques & tools on 5 research dimensions: (1) automated AdCoS re-configuration based on e.g. real-time predictive human models; (2) holistic formal (human & machine) modelling and accelerated analysis; (3) new empirical task, exploration and validation analyses of AdCoS; (4) a formalized synergetic empirical and model-based methodology; (5) integration of all techniques & tools in a Human Factors Reference Technology Platform (HF-RTP) to foster interoperability and to support human factors along the whole engineering life-cycl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Transfer of expertise in atmospheric monitoring of urban pollutants'.

assistant: **Concept**

Monitoring the chemical composition of the Earth's atmosphere is essential in order to understand and model the most relevant atmospheric processes and assess their impact on the development of the Earth's climate and the consequences for modern society. The Centre for Research into Atmospheric Chemistry (University College Cork, Ireland) requires the experimental know-how in applied remote-sensing methodologies and field campaigns, backed by theoretical expertise on atmospheric modelling to advance several highly innovative lab-based spectroscopic approaches for ultra-sensitive trace gas detection in the troposphere. It is the long-term ambition of TEAM-UP to establish a Centre of Excellence as a base for a national training network for atmospheric scientists working at Universities and research institutes over the whole island of Ireland. The proposed knowledge transfer will generate new and tighten existing links with large-scale multi-national research efforts in atmospheric sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Eco-efficient machine-tools by means of radical mass and energy needs reduction'.

assistant: **Innovation**

The ECOFIT proposal addresses as general objective a drastic reduction of the mass of machine tools for production systems (around 70% for structural components and motion units) and, consequently, a reduction of the energy consumption (around 30% less) fo r the use of these new type of machines. ECOFIT represents a radically new approach to industrial machinery conception, aiming at the development of a radically new technology for cleaner and more efficient production, by means of a paradigm shift: changin g from current stiff and massive machinery, with high energy consumption, to lightweight elastic machines with controlled flexibility and thus much lower enrgy needs. This new approach of lightweight elastic machines with controlled flexibility" represent s an important novelty regarding the way production systems are conceived. It is estimated that currently, approximately an 80% of the total mass of a machine tool is used to stiffen the machine for accuracy purposes, whereas only the remaining 20% is used to fulfil the kinematic requirements of the machine. With the aim of approaching this separation between mechanical stiffness and accuracy in machine tools, this project will combine mass reduction strategies in combination with new control strategies ba sed on damping considerations and new optical servoing solutions. The cornerstone of this new machine conception philosophy is that accuracy will be achieved by mechatronic stiffness against disturbances and external perturbations instead of using mechanic al stiffness to achieve that robustness. This project will reach the frontiers of current knowledge by the synergetic combination of new eco-design methodologies, innovative robust controllers for the flexible mechanism systems, optical servoing and smart mater
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Trust and Transparency for  The Food Supply Chain' (FreshIndex).

assistant: **Innovation**

Contrary to popular opinion, most foods can be consumed for much longer than the expiration date stated on the label. These expiration dates lead to good food being thrown away and wasted unnecessarily. With the use of state-of-the-art technology, all this waste and resulting costs can be prevented.Over the past years, the food industry has adopted the EPCIS standard that enables creating and sharing food tracking data. The state-of-the-art approaches to food safety and quality range from scanners, tests, TTIs, sensors, traceability and food chain analytics but they all require hardware and do not provide any information to consumers.We have created FreshIndex, a platform for the exchange of data on food quality and safety, to provide all parties information on exact and true freshness of the food. This platform will be offered as a service to the numerous retail chains. It will allow consumers to use their mobile phones to scan the product barcodes and get detailed information on the product production, its path to the consumer and the remaining shelf-life. The FreshIndex is the exact expiry date which will replace the current sub-optimal solution and contribute to reduction of costs and food waste. As our main pilot users are currently in retail, we consider European grocery retail chains as our serviceable obtainable market (SOM). We envision an AaaS (Analytics as a Service)  model where the players along the supply chain pay to get access to the data. This platform gathers special technological and food safety know-how. We will create revenues by charging retailers a small annual fee, tracking food cargo and charging for large API volumes.Matthias Brunner, our co-founder, has 10 years of experience in the development, sales and marketing of automotive sensors at Rob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Collaborative Integrated Communications For Construction' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The primary objective of CICC is to see whether the efficiency of dispersed and temporary teams can be improved through the use of intuitive and 3D user interfaces to new and existing information and communication services.CICC will therefore demonstrate and evaluate a range of Telepresence, WWW, Augmented Reality and Multimedia services mainly within the construction sector.Major efficiency improvements are anticipated from two factors:- Improving understanding by presenting the right information in the right format to the right person at the right time.- Improving collaboration by using visualisations to encourage participants to see project issues from a common point of view.Expected Achievements - Demonstration of all components of the Telepresence in Construction vision within the context of trials.- An integrated techno-economic and psycho-social evaluation of the implications of these trials.- A demonstration of an integrated vision of how a range of Information and Communications Technologies can be integrated to support collaborative work over networks.Expected Impact CICC will demonstrate how a range of visualisation technologies can be used to improve understanding by all participants in the project.- By presenting the right information in the right format at the right time, CICC will show how the full potential of all project participants can be released to improve the efficiency of the project.- By holding electronic records of all decisions CICC will show how quality can be maintained while responsibilities are devolved within a more federal project framework.Recent studies have indicated savings of more than 30% from a more collaborative approach to construction projects. Virtually all of these improvements are dependent on the technologies being explored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biodynamic modelling of toxic metal accumulation by the lugworm Arenicola marina, a keynote deposit feeding polychaete in European estuaries: ecotoxicological and regulatory implications' to be submitted under Seventh Framework.

assistant: **Abstract**

It is proposed to model the bioaccumulation of the toxic trace metals zinc (Zn) (essential), cadmium (Cd) and silver (Ag) (both non-essential) by an infaunal benthic invertebrate, the lugworm Arenicola marina, a keynote species in European estuaries, from solution and diet (sediment) using biodynamic modelling. The predictions of a model constructed from biodynamic accumulation parameters (uptake and efflux rates, assimilation efficiencies) measured in the laboratory will be validated against field data (from biological and physical (water and sediment) samples) from reference and metal-contaminated estuaries, particularly in southwest England. The subcellular compartmentalisation of accumulated trace metals in the lugworms will be fractionated into detoxified and non-detoxified components to model the metabolically available metal fraction, thereby predicting the potentially toxic fraction of accumulated metal, and hence toxicity. Toxicity tests will then be used to seek correlations between modelled concentrations of the potentially toxic component of accumulated metal and the environmental exposure conditions causing ecotoxicological effects in the field. The conclusions of the project will contribute to the advancement of our ability to develop a scientifically consistent basis for making a transition from the predictive modelling of bioaccumulation to the prediction of environmental thresholds of ecotoxicological effects. The results have the great potential to contribute to the implementation of environmental quality standards – for example, those for sediments in the Water Framework Directive.