RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nitrogen Fixation Research for a Future Sustainable Agriculture: Co-Operation Between the EU the Developing Countries' (1998-2002).

assistant: **Concept**

The proposed measure aims to bring together up to 40 researchers from the EU and from developing countries - partially active in EU-funded projects - during teeth European Nitrogen Fixation Conference to be held in September 2000 in Sevilla,Spain. The Conference will offer a special oral session were selected speakers will have the opportunity to present their results. All participants invited will also contribute to the poster session. For publication of the results presented especial issue of the Journal of Biotechnology will be prepared. In summary, the measure will provide a platform where researchers from developing countries and the European Union will meet, exchange their results and discuss the state of theatre and emerging aspects of biological nitrogen fixation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Biophysics of Reverse Transcription and its Inhibition'.

assistant: **Concept**

As the major target for therapy, Reverse Transcriptase (RT), and in particular the RT from the HIV virus, has been the subject of extensive research. However, despite an ever-increasing amount of information from traditional “bulk” studies, the detailed mechanisms of polymerization are still not completely understood. This is due, partially, to the stochastic nature of individual enzymes, which makes it impossible to follow more than one or two individual steps of polymerization using ensemble methods. I propose here to conduct a single-molecule, mechanistic study of HIV RT, by developing a high-resolution optical-tweezers, capable of resolving the individual polymerization and translocation steps of RT at a broad range of forces and nucleotides concentrations. Characterizing the dwell-time distribution at different experimental condition will allow us to study the complete mechano-chemical cycle of RT, its regulation by the template’s backbone-composition, structure and sequence, its interaction with additional viral and host factors, the molecular basis of inhibition by known inhibitors and the mechanism of resistance acquired through different mutations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing efficacy and safety of genome EDITing approaches for Sickle Cell Disease' in the context of a Horizon Europe call.

assistant: **Objectives**

Sickle cell disease (SCD) is one of the most prevalent monogenic diseases in Europe. A single amino acid substitution in the beta-globin chain of the adult hemoglobin (Hb) drives red blood cell sickling and multi-organ damage. The clinical severity of SCD is alleviated by the co-inheritance of mutations causing expression of fetal gamma-globin in adult life ? a condition termed hereditary persistence of fetal hemoglobin (HPFH). Transplantation of autologous, genetically modified hematopoietic stem/progenitor cells (HSPCs) is an attractive therapeutic option for SCD patients. To this end, genome editing approaches based on the use of site-specific nucleases or, more recently, base editors have been explored by many groups, including teams in our consortium. These approaches either correct the single point mutation causing SCD or reactivate fetal gamma-globin expression by mimicking HPFH mutations. On the other hand, (pre)clinical data from SCD patients or SCD mouse models, as well as preliminary data from our labs suggest that SCD HSPCs are characterized by a high mutational burden, oxidative stress and expression of inflammatory genes.  This can alter HSPC properties as well as their interactions within the bone marrow niche. In the context of gene therapy, it is essential to understand the mechanisms underlying SCD HSPC dysfunction and assess the impact of genome editing approaches on SCD HSPCs. In this proposal, we have assembled a multidisciplinary team to: (i) understand the molecular and cellular mechanisms underlying SCD HSPC autonomous and non-cell-autonomous dysfunctions and (ii) evaluate the impact of established and novel genome editing approaches on SCD HSPC properties and genome integrity. This study will lay the foundation of an improved gene therapy strate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel optical display technology based on MEMS and metasurface structural colors targeting sustainable displays for consuming electronics' (OPTICS).

assistant: **Concept**

The OPTICS project aims to improve the recent reported display technique of MEMS (Microelectromechanical systems) metasurface structural colors (applicant’s previous work), through re-designing the color filers and the MEMS cantilevers, for practical display applications for consuming electronics. The proposed technology combines transmission-based plasmonic structural colors with MEMS micro cantilevers to realise full range RGB displays, while using only two common earth-abundant materials: Aluminum (Al) and silicon oxide (SiO2), potentially for cost effective products and fast operation performance. Optical displays play a ubiquitous role in daily life, being an essential component of smartphones, computers, televisions, etc. However, these devices make up roughly half of the 50 million tons of e-waste produced globally every year. In estimate, 40 million tons are generally ending up in burn pits or landfills in developing countries, causing environment and health problems. There is an urgent need for alternative display technologies which are easier to recycle and are financially feasible to be incorporated into sustainable consumer electronics. Structural colors could be an ideal technology for next-generation optical displays. Several reports have been published on controllable / tunable structural colors towards optical displays. However, none of them meet the basic requirements, namely: control individual pixel by voltage, control color of individual pixels, and control brightness of individual pixels. We will examine a new type of optical display technology based on structural colors and MEMS to meet the above requirements. Implemented at the University of Southern Denmark, this project will allow the fellow to enhance both scientific and communication skills, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ShoppingMate: A location- and context- aware service for assisting consumers during their shopping time' under Seventh Framework.

assistant: **Concept**

The main objective of the proposed ShoppingMate project is the conceptualization, design, implementation and demonstration of a novel mobile application that will allow mobile consumers to: - describe in an intuitive semantic way the characteristics of an  item(s) they want to purchase (e.g. an intelligent toy for a 7-year old girl that is small size and does not cost more than 30 euros), - perform an intelligent search in a shopping area to locate shops that offer this category of product, - get, in an intuitive way and at as much detail as required, the matching products found, - formulate a shopping plan, and finally, - get directions to the selected shop(s) according to the plan.  ShoppingMate will research the state-of-the-art of all relevant Web 2.0 technologies, extend them as needed to achieve project objectives, and finally combine them in an end-to-end prototypical platform for mobile shopping support that will be much more powerful than anything else that comes close to this vision and is available today. The project will design a flexible user interface that supports menu-driven, free text, and natural language based capture of user requests. It will provide to participating shop owners the flexibility to incrementally introduce new item categories to the system and control the level of detail provided for each item. A semantic representation of both the user requests and the items offered for sale through the system will facilitate efficient semantic searching and matching. Semantic data representation will be performed using the Web Ontology Language (OWL) which is a semantic markup language for publishing and sharing ontologies on the World Wide Web. The ShoppingMate platform will be designed with user privacy in mind and will not require that the partici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New avenues towards solving the dark matter puzzle' (NewAve) under Horizon 2020.

assistant: **Objectives**

It is now firmly established that most of the matter in the Universe is in the form of the mysterious dark matter,contributing more than 80% to the total amount of matter. However, despite tremendous theoretical andexperimental efforts over the past few decades, dark matter remains elusive and one of the great unknownsuntil today. To identify the nature of dark matter is evidently of fundamental importance and one of thetop priorities in science today. The quest for dark matter is inherently multi disciplinary with strong rootsin particle physics, astrophysics and cosmology, providing profound connections between these differentdisciplines.This project aims at exploring new avenues towards solving the dark matter puzzle, with a particular focus ona few select groundbreaking topics. These are centered around (i) theoretical dark matter model building, (ii)the study of new collider signatures, (iii) developing new techniques for the comparison and interpretation ofdirect detection experiments and (iv) identifying astrophysical probes which constrain or give evidence fordark matter self-interactions.Given the impressive increase in sensitivity of upcoming dark matter experiments as well as the upcominghigh energy run of the Large Hadron Collider, there is no doubt that the era of data has begun for darkmatter searches and that we can expect putative signals rather than exclusion limits for the near future. It istherefore extremely important to bring together different fields and exploit the complementarity of differentsearch strategies to maximise the amount of information gained from a successful detection. This inherentlymulti disciplinary approach is at the heart of the current project, which can rely on a well established networkof collaborators and will bring together
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modulation of mitochondrial complex I as a strategy to increase lifespan and prevent age-related diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Nowadays, ageing is one of the main problems in Western society. The increase in the percentage of elderly people serves to strain the Social Security to the point of bankruptcy. The only way to alleviate the suffering caused by age-related degenerative disease is to fully understand the underlying forces which drive ageing and design strategies to delay it. Mitochondria are considered as central modulators of longevity in different species. It has been proposed that free radicals cause the accumulation of oxidative damage and as a result ageing. In accordance with  this, production of Reactive Oxygen Species (ROS) by complex I negatively correlates with longevity. However, the overexpression of antioxidants or the reduction of ROS levels does not increase lifespan. These contradictory data can only be reconciled if complex I is modulating longevity through a ROS independent mechanism. We have expressed the alternative internal NADH dehydrogenase 1 (NDI1) from Saccharomyces cerevisiae in Drosophila melanogaster. The expression of NDI1 does not change the level of ROS but increases both the ratio of NAD+/NADH and Drosophila longevity. The main objective of this proposal is to study the mechanisms by which complex I regulates longevity. My general hypothesis is that complex I regulates longevity through a ROS independent mechanism. I propose that complex I controls the cellular levels of NAD+/NADH, keeping their levels at an equilibrium that favours the optimal functioning of the cell. When the ratio is moved towards NADH ageing is promoted, whereas when it is moved towards NAD+ pro-survival pathways are activated. I proposed two specific mechanisms downstream of complex I that promote cellular longevity or senescence: 1) activation of sirtuins, which would increase genom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TRansferring ACademic Knowledge' in the context of a Seventh Framework call.

assistant: **Objectives**

Over the past thirty years, Knowledge Transfer Activities (KTA) have come to be considered as a natural stage in the evolution of the modern university, in addition to the more traditional mandates of education and research. KTA by academics are accomplished in different forms. Some of them, more discovery-driven, are characterized by the enforcement of intellectual property right, such as patenting, licensing and creation of new business based on patent. Some others, such as consulting and collaboration with industry, are more construction driven and are undertaken outside the Intellectual Property system (IP-system). The vast majority of studies on KTA examine entrepreneurial activities generated as a result of a formal disclosure process that occurs within the IP-system. Thus, very little is still known on the breadth and depth of KTA, on the impact that these activities have on academics' research productivity, as well as on the effectiveness of university support mechanisms in fostering them. In order to fill part of this void, aim of TRACK is to: a) gather new primary and secondary data on KTA undertaken by a representative sample of the academics in the U.K.; b) complement this information with empirical evidences on their research productivity and highlight the trade-offs (if any) between KTA and research; c) identify the support mechanisms put in place by universities as well as the TTOs’ business models, spotting the best practices in the support of KTA. Adopting a multilevel approach and relying on advanced econometric technique, TRACK will characterize the depth and breadth of KTA undertaken by academics in U.K, assessing the impact that KTA have on individuals’ research productivity and exploring the impact that different institutional characteristics have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Manufacturing of biodegradable and compostable packaging nets through a conventional one-step extrusion process' (BioPackNet) under Horizon 2020.

assistant: **Objectives**

European demand for plastic in 2014 was 47.8 M tonnes, of which 90% came from non-renewable sources. Moreover, 25.8 M tonnes of plastics ended up in the rubbish, with 30.8% completing their life cycle in landfills. Suitable sites for landfill across Europe are running out and public concerns are increasing about the impact of landfill on the environment and health. Reducing the quantities of waste that ultimately ends up in landfill has become imperative in the EU (Landfill Directive 1999/31/EC) and represents a particularly difficult task to achieve. Recycling is one of the most important actions currently available to reduce the impact of waste and plastic production. However, some packaging items such as nets (e.g used to package potatoes, oranges) are not suitable to be treated in recycling facilities as they are difficult to be cut and get entangled in the sorting equipment ending up as waste in landfills. One possible solution is the development of biodegradable and compostable materials that could be processed through extrusion melt spinning (EMS) to manufacture these nets. Some advances have been made in this area but the high price of the final packaging product make these alternatives economically unviable. Ecoplas, a spanish manufacturer of packaging nets has come up with a solution: Biopacknet. Biopacknet will be the first packaging net with improved physical characteristics that will be processed through conventional EMS, saving energy, quantity of material and above all at a competitive cost. Biopacknet will turn into compost when it reaches its end of life, giving life to plants that will become raw materials for biopolymers in Biopacknet's formulation, closing the loop to a circular economy. With sales of 1312 tonnes of packaging net, a turnover of €5,5M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting integrin signaling in tumour-associated macrophages to combat cancer progression and resistance' (MacrophInt).

assistant: **Innovation**

Cancer is the most common cause of death and morbidity in Europe. New therapeutic targets to combat this disease are critical. Across many solid cancers, poor prognosis largely correlates with the infiltration of tumour-associated macrophages (TAMs). TAMs enhance tumour progression and complicate various anticancer therapies. Although macrophages primarily employ amoeboid migration for homeostasis and immune functions, TAMs primarily utilize mesenchymal migration. Experiments in mice revealed that blockade of TAM mesenchymal migration lowers infiltration within tumours and reduces tumour growth. Targeting this distinctive feature has the potential to limit TAM recruitment in tumours and halt disease progression, while preserving healthy macrophage functions. The mesenchymal migratory mode involves podosomes and is characterized by integrin-mediated adherence to the surrounding extracellular matrix (ECM), and the requirement of ECM proteolysis. In sharp contrast, amoeboid migration is independent of podosomes and integrins. We will investigate and evaluate the potential of targeting integrin signaling as a new strategy to manipulate TAM infiltration into tumours. Elegant knock-in and knockout mouse models will be used to establish the key regulators of integrin signaling in TAM mesenchymal migration. This novel paradigm will be extended to TAM migration in human breast tumour specimens. We will also provide new insights at the subcellular level by exploring the roles of integrin signaling in the formation and function of podosomes. Our study endeavours to identify novel and unanticipated avenues for blockade of TAM mesenchymal migration and tumour infiltration to synergize with current combination therapies that simultaneously target both pro-tumour stromal cells and can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A new instrument for mapping the ultrafast photo-conductivity of materials for optoelectronics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The introduction of new photo-active materials with enhanced performance is enabling a fast technological development in fields such as photovoltaics, photodetection, display technology and imaging systems.  The efforts on the improvement of the synthesis and growth of these materials are in many cases not accompanied with equal efforts on the development of appropriate techniques that enable their characterization. MicroMap aims to develop a commercial instrument for the contact-free characterization of the high frequency photoconductivity of materials. The demonstrator will consist of an optically pumped near-field microscope and far-field spectrometer to map the response of photo-excited materials over areas of varying size from micrometers to several centimeters. This unique combination of length scales will enable to probe the conductivities of full devices and to determine the conductivities and carrier life times in single or few nanostructures or small areas to define the microscopic origin of the factors limiting the photoresponse. To demonstrate the feasibility of the instrument for the characterization of materials, we plan to test it on novel materials being currently investigated for optoelectronic applications. These include graphene, nanowires and perovskites. These tests will be used to elaborate technical notes that will help the commercialization of the instrument. The outcome of this project will be licensed to Protemics GmbH, which is a privately held spin-off of the research company AMO GmbH and the Institute of Semiconductor Electronics (RWTH Aachen University) with a background of two decades in THz technology .  The target market for the instrument is academic and industrial research organizations working on materials research. We will also carry