RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artificial ligands for chemokine receptors - tools for analysis and therapy' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The identity of the long-elusive accessory factors for cellular infection by HIV- 1 has recently been shown to be family of seven-pass membrane proteins that naturally function as cellular receptors for the chemotactic and immunomodulatory chemokine proteins. However, many remaining questions concerning their role in infection in vivo have been hampered by the lack of highly specific and sensitive reagents. We aim to develop such reagents and, in doing so, shall investigate their potential as therapeutic agents. More specifically: 1. To develop novel ligands for chemokine receptors based on the selective evolution of ligands by exponential enrichment (SELEX) method. 2. To use biotinylated synthetic peptides derived from the extracellular portions of CXCR4, CCR5, CCR2b and CCR3 as selective agents and 2'-NH2 modified RNA as the library in physiological saline. 3. To screen the artificial ligands (aptamers) thus generated for specificity vs. cross-reactivity; for their ability to block chemokine receptor function; for their ability to block HIV- 1 infection in various primary and established cell types; for their affinity and binding kinetics to chemokine receptor-derived peptide in vitro; for their utility as flow cytometric and cytological immunofluorescent reagents for the detection of chemokine receptor expression. Training content (objective, benefit and expected impact) Acquisition of a range of skills in the following, leading-edge areas: molecular biology, nucleic acid chemistry, computer modelling, cell biology, virology. Experience of working in a major international institution with English as the principal means of communication. Links with industry I industrial relevance (22) The sponsoring laboratory has links with the Europea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hybridizing Creative Writing Research: A Creatical Self-Portrait' (CRESP) targeting Horizon 2020.

assistant: **Abstract**

CRESP explores the eclectic discourses of nascent Creative Writing (CW) research, for the first time bringing together its practitioners from across language borders. This will serve to decolonialize a discipline currently dominated by the English language and introduce CW into the field of artistic research, in which it has been absent due to its monolingual orientation. My involvement in artistic research since 2010, my skills in ten languages as well as data collection, on-site networking and a multilingual video conference to be held during the fellowship will establish an international CW research network. Likewise, the project will help to push the world leading research of Lancaster’s Creative-Critical Writing (CCW) group beyond its current English-language orientation.Benefitting from the above cutting-edge expertise, I will research an amalgamated epistemic-aesthetic kind of writing that I term ‘creatical. My aim is to gain a better understanding of its discursive-stylistic workings, its manifestations in (un)controlled narration, its likely connections to second-language writing and its capacity to challenge existing orders. To this end, I will combine methods of 1) literary exegesis, 2) qualitative research and 3) literary practice in stages of hermeneutical progression. The resulting discourses – 1) metatextual writing, 2) polyphonic character speech and 3) stream of consciousness – will be merged into one creatical narrative. Knowledge-endowing insights emerging during its revisions will be displayed in a poetological cartography.Securing the expertise gained through the proposed research is particularly urgent since Creative Writing is now a fully recognized form of research in the UK, whose participation in European funding programs is uncertain as of 202
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis System of Symbolic Official data' (ASSO) targeting Fifth Framework.

assistant: **Abstract**

ASSO will design methods, methodology and software tools for the analysis of multidimensionnal complex data (numerical and non numerical) coming from very large databases in statistical offices and administrations. Symbolic analysis is an extension of statistical data analysis methods to more complex objects called Symbolic Objects. ASSO will improve the software developed in SODAS project in order to render it more operational and attractive following the users requests as well as to add new innovative methods and to meet the needs of statistical offices.Objectives:The general objective of ASSO is to design methods, methodology and software tools for the analysis of multidimensional complex data (numerical or non numerical) coming from very large databases in statistical offices and administrations. Symbolic analysis extends statistical data analysis methods to more complex objects. Individuals processed by these methods are complex in the sense they represent groups of individuals, featuring variation among each group of individuals. Within the context of the project, the complex objects are called symbolic objects. The aim of the ASSO project is to improve the software built previously in order to render it more operational and attractive following users requests, to add new innovative methods and to meet needs of statistical offices.Work description:ASSO project will allow adaptation of statistical concepts to the dynamical global environment, will suggest methodology of treatments and will give guidance on understanding the data. Special attention will be given to background knowledge and Metadata in order to provide a meaning" to the data, thus avoiding false interpretation due to data misunderstanding. Special care will be given to user-friendly human/machine int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'International Conference on Research Infrastructures (ICRI) 2026 in Rome (Italy)'.

assistant: **Concept**

The International Conference on Research Infrastructures (ICRI) is a significant event that convenes policy experts, facility managers, leading researchers, and various other stakeholders to discuss challenges and emerging trends for research infrastructures (RIs) in the global context. The aim of the project is to facilitate the organization of the ICRI 2026 conference in Rome, Italy, in October 2026.The conference will be organized by the Consiglio Nazionale delle Ricerche (CNR), the largest public research institution in Italy, which coordinates scientific research across disciplines, sectors, and regions. This effort will be in collaboration with the Italian Ministry of University and Research (MUR) and under the auspices of the European Commission (EC).The overall objectives of ICRI 2026 are to explore and promote the dual role of research infrastructures as:-Drivers of socio-economic impact, through developing frameworks that measure their contributions to research, innovation, regional and global development, public services, workforce skills, and broader societal benefits.-Instruments of science diplomacy, by demonstrating how RIs facilitate international collaboration, foster trust among nations, support global scientific responses, and contribute to peace, openness, and mutual understanding.Improved policy and management in the area of research infrastructures may have widespread impact across regional economies and significantly contribute to addressing global challenges. ICRI 2026 will facilitate the sharing of knowledge and the dissemination of best practices on effectively organizing RIs.


**Keywords:** research infrastructures, international cooperation, R&I policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Terahertz excitons in monolithically integrated carbon nanostructures' (TeraExc) targeting Horizon Europe.

assistant: **Abstract**

At present, mobile networks and emerging wireless technologies (internet of things etc.) require broadband channels to exchange rapidly a huge amount of data. The usage of frequencies from 0.1 to 10 THz has potential to increase the state-of-the-art high speeds by 2 orders of magnitude. However, despite the latest advancements in THz technology, we still lack proper materials to realize suitable THz photonic components. This project aims to understand principles of designing THz devices based on carbon nanostructures integrated into a monolithic flexible and durable substrate. The route to harnessing THz radiation for compact devices is seen in the usage of carbon nanostructures as building blocks for detectors, emitters etc. Such carbon nanostructures, as nanotubes and graphene nanoribbons, exhibit unique electronic and optical properties that make them very promising candidates for THz components. However, carbon nanotube and nanoribbon monolithic on-chip integration is challenging because it may results in significant change of their intrinsic properties after an embedment into a substrate. We propose to investigate with first principles and theoretical methods the successful routes of such integration and calculate electronic and optical properties of the integrated structures. We shall model such systems with 2D graphene superlattices. In these structures, quasi-metallic and dielectric regions can be alternated, for instance, either by selective hydrogenation of graphene or by embedment of boron nitride regions. The project will focus on (i) spin-orbit interactions and the topological edge states at interfaces; (ii) topological singularities in optical matrix element and (iii) excitonic effects. This project has a significant impact in THz technology and wireless c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Dynamic View on Conscious and Unconscious Processes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Distinguishing between conscious and unconscious processes is a fundamental issue for our understanding of the human mind. Most research on this topic has been limited to a static perspective, by studying static stimuli, by considering processing as a function of present information, and by focusing on a single, adult stage of development. Yet, both conscious and unconscious mental processes are intrinsically driven by dynamic properties. We will study these properties by relying on behavioral and brain imaging methods along three tracks:1) Unconscious perception: Our visual system is, in real life, constantly receiving unconscious sequences of information that will generate dynamic and constantly updated processing streams. We will study these dynamic unconscious streams, thanks to Gaze-Contingent Substitution, a novel approach allowing for the presentation of subliminal videos and sequences of stimuli.2) Conscious perception: Construction of a conscious percept does not only depend on present stimulation but also on interactions with prior knowledge. Relying on the Bayesian framework, we will study the mechanisms by which prior knowledge leads to the reconstruction of perceptual contents, by ""filling-in"" missing information during situations of partial awareness.3) The maturation of consciousness: Using both psychophysical measures of visibility thresholds and high-density EEG, we will study the neural distinction between conscious and unconscious processes in pre-verbal infants, and whether consciousness develops through the maturation of posterior brain regions encoding sensory information, or rather anterior prefrontal regions related to attention and executive control.The expected impact of the project will be 1) to evidence sequential and complex forms of subli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'QCD for the Future of Particle Physics'.

assistant: **Objectives**

The momentous discovery of the Higgs boson in 2012 marked the start of a new era in particle physics.  The increase in energy of collisions at the Large Hadron Collider (LHC) this year allows us to probe fundamental physics at an energyscale which has been out of reach until now.  This presents a challenge to particle theory to keep pace with these developments, and respond to the fact that Standard Model interactions will have different features in this new energy range.  We must understand these differences in order to extract as much information as possible from LHC data, and in particular to identify any signs of new physics.  My framework, High Energy Jets, is the only tool of its kind to include the dominant high-energy corrections to all orders in the strong coupling and these have already been shown to be necessary to describe data at the lower collisions energies of 7 and 8 TeV.  However, these corrections alone are not enough.My proposed research programme will develop a novel and powerful framework for theoretical predictions based on the lessons learned from LHC Run I.  In particular it will combine the necessary high-energy corrections with state-of-the-art next-to-leading-order (NLO) fixed-order descriptions. A separate objective is to combine the high-energy corrections with the resummation contained in parton shower programs.  This is necessary to describe data in regions where there is both evolution in rapidity and transverse momentum.  The ultimate goal is to combine all three: high-energy corrections, NLO calculation and parton shower.  Separate theoretical objectives will significantly improve our understanding of the underlying theory, which should ultimately enhance our description of data far beyond any current prediction.  This will be the most
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dissecting and Engineering Allosteric Activation in a Biosynthetic Enzyme' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Allosteric regulation of enzyme catalysis is widespread in nature and presents challenges and opportunities in synthetic biology. The enzyme ATP-phosphoribosyltransferase (ATPPRT) catalyses the first step in histidine biosynthesis, and is subject to complex allosteric inhibition by histidine. The short form of the enzyme, HisGS, is found in complex with a regulatory protein, HisZ. Such regulatory protein has a dual function: it allosterically enhances catalysis by HisGS, and it binds histidine and therefore mediates allosteric inhibition. The scientific aim of ""DEAllAct"" is to explore the design of a computational framework by combining state-of-the-art EVB/MM computational simulations and biophysical experimental studies to discover specific mutations at the protein-protein interface between HisGS and HisZ, that directly impact the transmission mechanism of the allosteric regulation. The fellow, Marina Corbella will carry out the project in Uppsala University under the supervision of Prof. Lynn Kamerlin who has extensive experience in computational chemistry and enzyme evolution. The first goal of ""DEAllAct"" is to elucidate the molecular details of the catalytic process of HisGS in the absence/presence of the regulatory protein HisZ via molecular dynamics simulations. Based on the information extracted from these simulations, a novel simulation tool will be developed to predict residues of key importance for binding interactions between the enzyme and the regulatory protein. Finally, the fellow will undergo a secondment at the University of St Andrews to test the hypothesis experimentally by introducing gain-of-function mutations on HisGS at the protein-protein interface to mimic the allosteric activation. Altogether, ""DEAllAct"" will provide the fellow with a hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Next Generation of SMARt Active Inceptor for Tilt Rotor Application'.

assistant: **Concept**

The SMAR-TeR project is aimed at identifying, developing, prototyping and pilot-in-the-loop validating a new class of active inceptors for civil tilt rotor application. The design will focus on inceptors’ mechanical interfaces and ergonomics so that NGCTR FCS augmentation can be further improved. At the same time studies on ergonomics, electromechanical senso-actuators, haptic capabilities, command logic including diagnostic capabilities and system integration by pilot-in-the-loop simulation at WAL premises will be part of SMAR-TeR commitment.The first step will consist in a specification review, a conceptual system design, trade-off activities and a technological innovation assessment with the final aim to identify the possible ergonomic architectures that match the WAL requirements and the tilt rotor specific application. Virtual reality based and 3D-printed methods will be used in order to define the best inceptor ergonomic architecture and functionality to improve the pilot and co-pilot comfort and workload reduction. Innovative inceptor with “haptic capabilities” will be implemented by developing software and hardware solutions in order to define an active inceptor systems that feeds information from the tiltrotor’s fly-by-wire system to the pilot through the inceptor itself. This “tactile cueing” will be one of the many benefits of the proposed active inceptor system. Algorithms modelling, simulation and performance analysis will be carried out in order to develop a new worldwide state of art inceptor for tiltrotor application. The system will be designed, produced and tested keeping in mind current trends in pilot haptic aiding that go beyond the variable stiffness or passive haptic aids characteristics currently adopted; the proposed hardware and software archit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Are fungal spores perfect projectiles?  Evolution of ascospore shape' in the context of a Seventh Framework call.

assistant: **Objectives**

Fungi are important components of our ecosystem since they both provide nutrition for many animals and are major recyclers of minerals and carbon. However, many fungi are parasites on plants, animals and other fungi. Serious fungal pathogens of cultivated plants cause extensive damage and losses to agriculture and forestry. The very common species usually found in pillows cause one of the most dangerous mortal infections in persons with immuno-deficiencies.  Fungi reproduction results in almost-indestructible spores, which are the major carrier of diseases. In many cases the spores are forcibly ejected clear of the parental fungus. The probability of the species to survive depends upon spores germinating far from the fruiting body where they are formed. Fungi achieve very large launch velocities, applying initial accelerations that are unmatched in the plant or animal kingdoms. Fungal-spores must minimize the air-resistance, which is the prime determinant of their range (it can deplete the launch velocity of as much as 99.997%). Can we set the shape of a “perfect projectile”? How can a spore be shaped to minimize drag, if it has never experienced air resistance?  In the first part of the project we study theoretically, numerically and experimentally the fluid mechanics of spore ejection. The second part inquires into the developmental process of spore shape theoretically and experimentally. The general idea is that evolution has selected the minimum-drag shape for spore survival. We plan to observe the formation of the spores inside Neurospora tetrasperma, one of the most studied model organisms of biology.