RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Site-specific Ultrasensitive Magnetic resonance of Mixtures for Isotopic Tracking' (SUMMIT) targeting Horizon 2020.

assistant: **Abstract**

There is a high demand to design approaches capable of tracking the origin of biomarkers in complex biological environments, in the areas of life, environmental, food and forensic sciences. Metabolomics and Fluxomics show great promises towards this aim, and a high potential arises from their combination with Isotopic fingerprinting at natural abundance. The resulting isotopomics approach requires cutting-edge analytical tools, and Nuclear Magnetic Resonance (NMR) is currently the only generic technique giving access to the site-specific isotope content at natural abundance. The detection of very small relative variations between samples originating from different (bio)chemical pathways is possible through 13C isotopic NMR, which can however only be applied to simple and concentrated samples, due to its low sensitivity. Consequently, numerous applications are out of reach. To tackle the current limitations of 13C isotopic analysis, SUMMIT will develop a groundbreaking analytical workflow relying on two of the most powerful NMR methods: dissolution dynamic nuclear polarization and ultrafast 2D NMR. This cutting-edge approach will allow the simultaneous measurement of 13C fingerprints from multiple low-concentrated biomarkers in complex mixtures, which is impossible with existing methods. The high potential of this analytical strategy will be demonstrated on a relevant biological study, the investigation of breast cancer cell metabolism, through applications with gradually increasing risk levels. These approaches will make it possible to identify (i) new biomarkers to discriminate between cell lines expressing different hormonal receptors; (ii) novel potential therapeutic targets from the elucidation of metabolic pathways. Beyond this application, the project will have a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Pepino mosaic virus: epidemiology. economic impact and pest risk analysis'.

assistant: **Innovation**

PEPEIRA is an RTD activity aimed at developing an EU-wide Pest Risk Assessment (PRA) for Pepino mosaic virus (PepMV). The proposal will investigate the epidemiology and economic impact of PepMV in order to allow a robust and scientifically-justified assessment of the risk posed by this pathogen to the European tomato industry. This includes a true assessment of the economic impact on tomato crops growing in Member States with different climatic and market conditions and the role of seed transmission in the spread of PepMV. The project will also address the increased risk posed by new, biologically and genetically distinct strains of PepMV that have appeared in Europe and elsewhere recently and have the potential to be far more damaging. The proposal will also address the issue of developing validated diagnostic protocols, to be published via EPPO that can be used with confidence by National Plant Protection Organisations (NPPOs) within the EU and laboratories in other countries that trade with the EU. In addition to a strong and focussed science program, the proposal also mobilises an impressive consortium, including all EU laboratories with a proven track record of PepMV research, with extensive plant virus and plant health expertise from all Member States where PepMV poses a potential risk. Consultation with the principle stakeholders (Plant Health Standing Committee, DG SANCO, growers and seed companies etc.) throughout the life of the project is given paramount importance. Adoption of the new PRA will allow EU Plant Health services to develop, via Council Directive 2000/29/EC, a consensus on appropriate measures to prevent PepMV becoming significant detrimental to the EU tomato industry. This in turn will help to prevent any negative impacts on the sustainability of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Collective Attitudes and Normative Disagreement' (CAND), addressing dissemination and exploitation.

assistant: **Impact**

CAND - Collective Attitudes and Normative Disagreement concerns the perspectival nature of legal discourse. The main aim of the project is to increase our understanding of legal and normative discourse in light of contemporary accounts of the semantics and pragmatics of deontic modals, and of collective intentionality. This is a highly interdisciplinary project, connecting various philosophical disciplines with jurisprudence. The project will apply state-of-the-art theories and arguments of contextualist semantics about deontic modals and value predicates to the case of statements of law (i.e. statements of what, according to law, one ought to do). This will be achieved by a systematic exploration of the relationship between four debates in four different areas: first, the problem of the semantics and pragmatics of ought and might claims in philosophy of language; second, the debate on the perspectival nature of legal statements in legal philosophy; third, the debate on dispositional accounts of normative facts and values in metaphysics; and fourth the debate on collective intentionality in the philosophy of mind and action. Marques believes that there is a common set of issues underlying these seldom-connected debates. Her guiding research idea is that contextualist semantics is adequate for all normative statements, and difficult cases can be explained with a combination of (i) pragmatic accounts of the metalinguistic selection of appropriate standards, and (ii) proper accounts of collective intentionality. The project will pursue three objectives in particular: (O1) To develop the case for contextualism about deontic modals in the domain of normative legal statements and judgments. (O2) To investigate the role of joint commitments and collective intentionality in nor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deployment of support services aiming at enhancing the innovation management capacity and projects of SMEs based in the Hauts de France region' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project EURACTE-INNOV III proposed by the consortium Enterprise Europe Network EURACTE II aims at the deployment of two support services aiming at enhancing the innovation management capacity and projects of SMEs based in the new Hauts de France region (covering the previous Nord – Pas de Calais and Picardie regions), thus generating growth and competitiveness among local actors : The first service targets successful applicants under the SME instrument scheme, i.e. “SME Instrument beneficiaries”. The aim of this service is to detect weaknesses in the projects, help the SMEs identify a coach who is competent in the particular field in order to efficiently accompany the SME in finding solutions to the identified challenges, and follow up and facilitate the SME-coach relationship in order to maximize the probability of the project to access the targeted market successfully. The second support service, “Enhancing SME innovation management capacity”, aims at helping regional SMEs with potential for international growth, to consolidate their innovation strategy and management, in order to generate more structured innovation projects and increase their chances of success on the European market. The overall objective is to allow those SMEs to reach the required capacities to access to funding under Horizon 2020 R&D programs.


**Keywords:** Innovation management capacity enhancement, Key Account Manager, SME Instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Architecture and roadmap to manage multiple pressures on lagoons' under Seventh Framework.

assistant: **Concept**

The ARCH research project “Architecture and roadmap to manage multiple pressures on lagoons” aims to develop participative methodologies in collaboration with policy makers, local authorities and stakeholders to manage the multiple problems affecting lagoons (estuarine coastal areas). These areas represent ecosystems that are very vulnerable for climate change, increasing urbanisation and industrialisation. A central feature of ARCH is to provide realistic solutions to manage these pressures and establish a better connection (the arch) between science and policy. This is accomplished by facilitating the transition (i) from segregated disciplinary scientific results to well integrated and usable scientific knowledge, (ii) from “government” and sectoral policies towards “governance” and sustainable management; and (iii) from an unaware and uninformed “lagoon community” towards an involved and well-informed community. ARCH will work with 10 case study lagoons and estuaries having a geographical distribution covering all major seas surrounding Europe. A participatory workshop methodology will be used at the lagoon sites to develop a decision framework to choose strategies, interventions and measures to manage the existing and future problems in the lagoon. This is accomplished using an integrated planning approach, considering ecosystem services to assess the social, economic and ecological state of the lagoon and linking this to spatial planning methodology. The final products of ARCH are roadmaps for implementation of realistic solutions at the lagoon scale, a management guide for coastal managers and policy makers in Europe and the European Lagoon Management Handbook. The project will actively disseminate products and experiences via newsletters, multiplier seminars, a w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ecosystem building blocks for the Next Generation Internet movement' (2014-2020).

assistant: **Concept**

We are yet again at a critical stage for Europe. With the threat of geopolitical instability coming from several dimensions Europe needs to not just assert its presence on the world stage, but moreover needs to assert its digital sovereignty to further its vision of a single digital market. The need for a European leadership role for the Next Generation Internet is clear.NGI MOVE is to inspire Europe to become a leader in the co-creation of the NGI in a more human centric, societal and economic beneficial ecosystem of researchers, high tech start-ups, industrial and government leaders as well as grassroots communities and individuals.The vision is to create a NGI that is at the service of people and stimulates business opportunities, centred on European values and competing globally. Our message is pragmatic cybernetics, balancing extreme centralisation and extreme decentralization where data stays with citizens.The main activities of the project are driven by the following activities:Connecting the Next Generation Internet Ecosystem is the primary activity, in that it identifies and engages with the most brilliant researchers, entrepreneurs and individuals.Co-creating the Next Generation Internet Ecosystem is all about creating content that fuels the community and motivates people to engage. Three sub-activities are to co-create: (1) the organisational model around the NGI flagship initiative. (2) the concepts and models that make up the characteristics for the NGI flagship initiative. (3) a number of NGI scenarios that can drive a vision and common basis for discussion amongst the many diverse stakeholders.The final activity is to launch the NGI Ecosystem. In essence this is the tangible outcome of the project that provides the basis for the NGI flagship initiative be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Electrophysiological and immunohistochemical characterisation of the mucosal enteric innervation of the guinea pig colon' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

In this project we propose to use a new approach to characterise and st the enteric innervation of tbe mucosa of the colon. The neurons innervating the mucosa will be first labelled with a retrograde tracer. The labelled and functionally identified neurons will then be characterised by using the simultaneous combination of electrophysiological, pharmacological and immunohistochemical methods.  Microelectrode recordings of membrane potential will be performed from labelled neurons and their response to various putative neurotransmitters examined. Finally. the projections of the labelled neurons will be determined as well as their neurochemical coding. A special emphasis will be put on the characterisation of intrinsic sensory neurons.  Such knowledge is of great importance to understand physiological and pathological processes controlled by the various classes of neurons innervating the mucosa. This study should also provide for the first time the link between the new-onal characteristics and the effector systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Implementation of patient involvement instruments to improve general practice care for older people in europe' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The proposed project develops and evaluates programmes that implement patient involvement instruments to improve general practice care for older people in Europe, resulting in an attractive toolkit of materials for general practitioners and patients in 11 European countries. Many instruments to measure patients' views and educate care providers have been developed but not implemented in clinical practice. This project builds a toolkit in three steps:1. An interview study to document and compare internationally the barriers for patient involvement in general practice care for older people.2. Programme development and case studies to develop and select programmes that can help to implement patient involvement instruments in this area.3 An international program evaluation to assess and compare internationally the most promising programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding and controlling the spatial organisation of cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

The spatial of organisation of tumours is the cumulative result of a myriad of cell-cell and cell-matrix interactions. These interactions determine the shape and relative positions of cells and the deposition and structure of the extracellular matrix (ECM), which feeds back to guide cell migration. The spatial patterns of tumours indirectly encode information about the likely future course of the disease, which is interpreted by pathologists to provide patient prognosis. To understand and control the spatial organisation of tumours requires not just knowledge of cell position, but of the underlying structural matrix. Furthermore, analysis of fixed tissues fails to capture information about cell movement or the relative sequence and kinetics of events. We will place both structural information about the ECM and dynamic analysis obtained through longitudinal intravital imaging and the centre of our work. We will focus on sequentially describing, understanding, and then re-configuring the spatial organisation of the tumour microenvironment. We will develop spatial metrics to analyse stromal architecture and link spatial features to disease outcomes in patient cohorts and therapy responses in intravital imaging studies. Reductionist co-culture assays and microfabricated tools will be used to study the mechanisms of cell-cell and cell-matrix crosstalk that generate spatial patterns. This analysis will be coupled to an agent-based computational model, parameterised using our experimental models, to explore both emergent pattern formation and possible mechanisms of interconversion between spatial patterns. Both experimental and modelling approaches will be used to identify effective mechanisms to control spatial patterns in breast and skin cancer models. Finally, interventiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Micro Dynamic Demand and Storage' to be submitted under Seventh Framework.

assistant: **Abstract**

Power outages can be caused by a defect in a power station; damage to a power line or other parts of the distribution system, a short circuit, or the overloading of electricity mains. Out of all the causes, most of them are minimised or preventable by better maintenance except the overloading of the electricity main (Power Grids), which can’t be completely predicted. Across Europe, overloading of the mains occurs more frequently and this in impacted by the fact that energy consumption in the EU is growing and this has significant environmental impacts. There are various measures taken to tackle the overloading of the mains, including predicting when these overloads occur and preparing back up power to cater for it, however, this solution would only help in minimising it. There will still be some cases of overloading especially due to the fluctuations of the demand on the mains. All the time, Power Grids must ensure that electricity supply precisely matches the continually changing demand from the vast amount of customers. Although most of the large changes in demand are predictable there are continuous smaller fluctuations which are essentially random. And there is also always the possibility that a sudden large fluctuation could occur at any time and the sudden increased demand can cause a power line or generating station to fail. Trying to control this issue costs the Grids hundreds millions of euros, and in some cases there have been the occurrence of blackouts in some countries. There is a need for an innovative approach to reduce the pressure being put on the Grids by effectively managing the energy consumption and demand on the Grid with the incorporation of Dynamic Demand technology. Therefore our concept is to develop an innovative Power Management System, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A single-cell genomics approach integrating gene expression, lineage, and physical interactions' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

From populations of unicellular organisms to complex tissues, cell-to-cell variability in phenotypic traits seems to be universal. To study this heterogeneity and its biological consequences, researchers have used advanced microscopy-based approaches that provide exquisite spatial and temporal resolution, but these methods are typically limited to measuring a few properties in parallel. On the other hand, next generation sequencing technologies allow for massively parallel genome-wide approaches but have, until recently, relied on studying population averages obtained from pooling thousands to millions of cells, precluding genome-wide analysis of cell-to-cell variability. Very excitingly, in the last few years there has been a revolution in single-cell sequencing technologies allowing genome-wide quantification of mRNA and genomic DNA in thousands of individual cells leading to the convergence of genomics and single-cell biology. However, during this convergence the spatial and temporal information, easily accessed by microscopy-based approaches, is often lost in a single-cell sequencing experiment. The overarching goal of this proposal is to develop single-cell sequencing technology that retains important aspects of the spatial-temporal information. In particular I will focus on integrating single-cell transcriptome and epigenome measurements with the physical cell-to-cell interaction network (spatial information) and lineage information (temporal information). These tools will be utilized to (i) explore the division symmetry of intestinal stem cells in vivo; (ii) to reconstruct the cell lineage history during zebrafish regeneration; and (iii) to determine lineage relations and the physical cell-to-cell interaction network of progenitor cells in the murine bone marrow.