RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'New supported catalysts for oxidative polymerization of phenols'.

assistant: **Concept**

New catalysts for oxidative polymerization, based on synthetic models of tyrosinase, supported on inorganic materials will be prepared and evaluated for phenol oxidation which is a potential method for phenol removal from wastewater. The first objective of the project will be (i)to synthesize new aminoacids/peptides - precursors and to polymerize them via sol-gel procedure (ii) to graft the aminoacids/peptides on modified silica and clay. The second step will be to incorporate metal ions, expecially Cu(II) which plays an active role in oxidation catalysis, in the new materials. The final step will be to study the ability of these new mixed Organic-Inorganic materials, to catalyze the oxidative polymeriza- tion of phenols by 02. Their catalytic properties will be compared with those of previously described catalytic systems. The expected result is a higher catalytic reactivity, as these 'artificial enzymes' will mimic more efficiently the natural enzymes like tyrosinase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sepsis Diagnosis via Integrated Breath Sensing System with Change-Point Detection for Real-Time Point-of-Care' in the context of a Horizon Europe call.

assistant: **Objectives**

Every 2.8 seconds someone dies from sepsis: 11 million people annually, out of which children under 5 years old. Septic shock is the potentially fatal body’s dysregulated response to pathogens that spread through blood circulation, including viruses like SARS-CoV-2. Half of sepsis cases happen in ICUs with 42% morality, with costs of €30 000 per case and €20 billion per year. Current diagnosis protocols rely on observation of the clinical symptoms to initiate regular monitoring of patients’ vital signs. Blood analyses and other tests identify the source of infection within 2-5 days, during which broad-spectrum antibiotics are administered, contributing to antibiotic resistance. Every hour of delay increases the mortality rate by 5-10%. Hence, early diagnosis of the infection source is a major step towards treatment. Pre-clinical and commercial point-of-care devices reduce the analysis time to few hours but still rely on the manifestation of clinical symptoms and invasive blood-based assays. SepsISensoR will advance the sepsis diagnosis protocol by non-invasive real-time monitoring of ICU patients’ breath to detect pre-symptomatic signs of sepsis based on transient changes of gas biomarkers in early sepsis stages. This will be achieved by: (a) integrating commercial gas sensors with fabricated preconcentrators on a single chip for high sensitivity, efficient and scalable multiple gas sensing; (b) using on-line change-point detection (CPD) on the breath signal to identify temporal variations of single- and multi-gas concentration; (c) validating the system with gases released from in vitro and in vivo models of sepsis. SepsISensoR will go beyond the state-of-the-art by reducing diagnosis time, and in turn reducing time in ICUs, cost, and sepsis fatalities. This aligns wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Prostate cancer trialists' collaborative group meeting 2002 (TCTCG MEETING)' in the context of a Fifth Framework call.

assistant: **Objectives**

The present request concerns the main meeting of the Prostate Cancer Trialists'Collaborative Group (PCTCG), for the second cycle of the Overview. The PCTCG is an international group collaborating in identifying and bringing together data from all randomised clinical trials to be analysed centrally to systematic review different questions addressed by randomised trials in prostate cancer. The meeting will take place in September 2002, to discuss preliminary results of this cycle of the Systematic Overview, to propose new analyses, to identify new questions to be addressed and to agree on a plan of action for the production of reports of results, publication and dissemination of results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improving European VoD Creative Industry with High Efficiency Video Delivery' (Film265), addressing dissemination and exploitation.

assistant: **Impact**

Film265 delivers a comprehensive approach to support European small and medium VoD services with the most innovative technology in video delivery. It aims at providing them with the technological edge needed to compete in the international market of film distribution in the internet. The core of Film265 is to adapt a HEVC/H.265 video codec for VoD scenarios, including a decoder integrated into a video player and an encoder integrated into a transcoding application in the cloud. This development will be supported by a comparison of HEVC/H.265 with current solutions that uses H.264/AVC for full length real-life film material.In order to assess feedback on the user demands and needs of the resulting video playouts Film265 will develop statistic tools that allow to determine the Quality of Experience by measuring buffering times, performance, delivery rate, the time watched etc. The tool will mainly consist of a plugin and a player that can be used by any VoD service around the globe.Finally, in order to create a fully market-ready solution, we will create APIs that allow all relevant industry participants to make use of what we have developed.The consortium consists of one university: TU Berlin (Germany), and three SMES: Reelport (France/Germany), Cinando (France) and LevelK (Denmark). TU Berlin (AES group) has an extensive experience on efficient implementations of video codecs, Reelport is a VoD provider for film festivals and other film-related projects. Cinando handles the market of the Cannes FIlm Festival, and LevelK is a Danish film distributor using VoD technologies. TU Berlin will provide the new video codec; Reelport its existing PicurePipe solution cloud encoding solution, and the new quality analysis tool; and Cinando and LevelK will integrate the new technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nonhuman primates as preclinical models : facility of chronic and degenerative disease in humans 'pcdd'' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Description:The Research Infrastructure PCDD at Biomedical Primate Research Centre (BPRC) is located in Rijswijk, The Netherlands and provides a unique possibility to investigate pathogenic mechanisms and new therapies for chronic and degenerative disease in non-human primate disease models. The centre has pedigreed breeding colonies of genetically characterised New World monkeys (common marmosets and cotton-top tamarins) and Old World monkeys (rhesus macaques) for biomedical research. The facility provides visiting researchers the necessary scientific and technical support for the experiments plus the usage of specialised laboratories and animal housing and care infrastructure. Studies of the kind undertaken in the infrastructure provide insight in genetic and immunological mechanisms operating in transplant rejection and chronic inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.Application:The research of the BPRC has immediate relevance in the field of therapy development. The permanent aim of the research group is to improve the existing models where necessary, for example by the implementation of clinically relevant diagnostic tools. Via basic research into the critical pathogenic mechanisms operating in the models is potential targets for more effective and safer therapy are sought. The vast knowledge on primate genetics and immunology present in the institute can form the basis for development of new disease models.Project Manager:Dr. Margreet JonkerImmunobiology DepartmentBiomedical Primate Research CentreLange Kleiweg 139, RIJSWIJK, Postbus 3306, 2280 GH á RIJSWIJK, The NetherlandsTel: +31-15-2842687Fax: +31-15-2843999Email: jonker@bprc.nl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced human models of the heart to understand cardiovascular disease' (HEART2BEAT), addressing dissemination and exploitation.

assistant: **Impact**

Cardiovascular diseases (CVD) are the cause of the highest mortality and morbidity rates worldwide and are expected to increase in coming years, leading to epidemic proportions. Traditional experimental in vitro and animal models are not predictive enough, which hampers the emergence of novel therapies for treatment of CVD. Consequently, there is an urgent need to establish realistic human models that lead to a better understanding of CVD, providing the opportunity to identify and validate druggable targets. In Heart2Beat I will develop innovative human heart models for mimicking cardiovascular disease. I will use an innovative in-air microfluidic platform for ultra-high throughput encapsulating of human pluripotent stem cells in microgels to generate self-organised multicellular 3D human cardiac organoids that replicate the architectural design of the human heart. Furthermore, I will integrate and develop innovative technologies from the fields of human stem cell biology and engineering to create 3D (micro)-engineered heart tissues, coupled to a versatile and automated microfluidic platform, enabling assessment of multifunctional analysis (e.g., contraction, relaxation, metabolism, morphology). Finally, I will build a functional human mini-heart with the capacity to pump fluid, the main function of the human heart and then assess clinically relevant readouts in healthy and diseased conditions. These first-of-its kind advanced 3D human cardiac models and platforms are complementary to each other and form a highly innovative and comprehensive pipeline for modelling human CVD, enabling (ultra)high throughput screening and in-depth multifunctional pre-clinical analysis of healthy and diseased heart tissues. Successful implementation of Heart2Beat will provide insight into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Informed Decision-Making for Agroforestry Systems in Africa through a Network of Living Labs' (AfroGrow).

assistant: **Innovation**

AfroGrow proposes a comprehensive strategy to promote and advance sustainable agroforestry practices across Africa, addressing key challenges related to climate resilience, biodiversity conservation, and socio-economic development. By focusing on collaboration, innovation, and capacity building, AfroGrow aims to transform agroforestry systems into resilient, multi-functional landscapes that enhance food security, mitigate climate change, and promote inclusive growth. Through a network of six Living Labs, AfroGrow will facilitate participatory research and innovation, enabling local communities, researchers, and policymakers to co-create sustainable agroforestry solutions tailored to diverse ecological and socio-economic contexts. These Living Labs will serve as hubs for knowledge exchange, technology transfer, and capacity building, empowering stakeholders to adopt and implement best practices in agroforestry management. AfroGrow will develop regional suitability maps for local plant species and animal breeds, facilitating informed decision-making for stakeholders. Simultaneously, it will conduct comprehensive impact assessments of regenerative management measures, providing evidence- and data-based recommendations for policy formulation and decision-making. This will enhance ecosystem resilience through sustainable land management practices and secure human well-being. Central to AfroGrow's approach is the promotion of gender equality and social inclusion, recognizing the critical role of women and youth in agroforestry development. By fostering equitable participation and representation, AfroGrow aims to amplify the voices of marginalized groups and ensure that agroforestry interventions benefit all members of society. Through collaborative partnerships, interdiscipli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INNOCOACH' (INNOCOACH) under Horizon 2020.

assistant: **Objectives**

Small and Medium Enterprises (SMEs) are leading power of economy. To unlock their potential EU provides many instrument for them.EU funding programs are one of the most important ones as it  promotes SMEs in very different ways. Innovation agencies have a vital role to promote SMEs competiveness through EU finding mechanism. If they have a structured way or methodology to transfer knowledge to SMEs, they will include more SMEs into the system which will bring  many different skills and competences to SMEs,INNOCOACH will aim to improve coaching service mechanism for the EIC Pilot programs among innovation agencies through analyzing different methods and best practices around Europe. Within 12 months of period, INNOCOACH -made up of 3 organizations, including 1chamber of commerce, 1 business Support organization and 1 innovation hub -, will develop the most effective ways of coaching on the new updated program in order to improve SMEs’ interest and satisfaction by exchanging good practices on coaching and providing sustainable synergy among related partners


**Keywords:** SME,innovation,EIC,coaching
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'GROundWater sustainability and crop production'.

assistant: **Concept**

Groundwater is the largest freshwater resource on earth and is crucial for people and the environment. In many regions around the world, groundwater is used unsustainably. Consequently, groundwater levels drop leading to drying rivers and wells, salt intrusion, land subsidence, and groundwater depletion. Irrigated agriculture is the largest user of groundwater worldwide and is responsible for current hotspots of negative impacts, especially for intensively irrigated regions of the world. Already, many rivers in these regions have reached their environmentally critical streamflow, which is necessary to maintain healthy ecosystems. With expected increasing water demands and climate change, the pressure on our groundwater resources will increase further and new regions experiencing negative impacts will develop. To reduce and prevent these impacts, groundwater uses should be reduced. At the same time, crop productivity should be maintained to protect global food security. This poses for me the urgent question: What is the current and future environmentally safe operation space for global groundwater use and what is, and will be, the impact of sustainable groundwater use on crop production worldwide? In this project, I will provide a better understanding of groundwater availability worldwide. My project will define the environmentally safe operating space for current and future groundwater use and will define and quantify the key trade-offs between sustainable groundwater use and crop production. I will develop a novel and innovative modelling framework that connects groundwater, surface water, and crop growth. The model will be linked novel future water demand scenarios, including adaptation strategies towards sustainable groundwater use worldwide. The results will show gl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'TRANsport with QUantum nuclei in Ionic Liquids'.

assistant: **Concept**

Transport coefficients govern the irreversible flow of extensive, conserved quantities, like mass, momentum, charge and energy. They are fundamental in both science and technology, governing from battery- and fuel-cell-efficiency to the lifecycle of planets. During the last decades, transport coefficients have been successfully extracted from equilibrium molecular dynamics (MD) simulations, according to the Green-Kubo theory of linear response. The theory has been also recently reformulated in ab-initio framework, thanks to the widespread use of density functional theory and new theoretical advancements, like the so-called gauge-invariance principle or novel data-analysis techniques. Despite these great advancements, when light nuclei are present, nuclear quantum effects can arise -like quantum tunnelling and zero-point energy effects-, which are not considered with standard molecular dynamics simulations with classical, point-like nuclei, and may strongly affect transport coefficients. In TRANQUIL we shall employ imaginary-time path integral molecular dynamics techniques to include NQEs in the transport properties of complex ionic liquids, relevant in energy-management technology and planetary science. Machine learning models will be exploited to construct ab-initio accurate force fields for faster MD simulations, as well as to define the atomic properties that are necessary to obtain well-defined microscopic fluxes needed in GK theory, like the dynamical charge or the local energy of each atom. TRANQUIL will also develop new, highly-scalable, and open-source software platform to manage the massively parallel MD simulations required, through the deployment of a targeted secondment. Within TRANQUIL, the experienced researcher will extend his scientific network of collab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural Biology of Membrane Proteins' in the context of a Seventh Framework call.

assistant: **Objectives**

Membrane proteins (MPs) are known to be key molecules in cellular communications, from signal transduction to transport of ions, metabolites and other molecules. They also participate in the synthesis of ATP, the import of soluble or MPs from the cytosol, and they protect living organisms from toxic factors. The proposal consists in a joint training effort involving the major biophysical methods that are -or soon will be- the major techniques used in the field of structural biology of MPs. A collaborative effort is essential for the training of the future generation of biologists dedicated to membrane proteins. It will pave the way to an integrative approach for the study of structure-function relationships of membranes. It will therefore open new strategies for structure-based drug design, in particular toward G-protein coupled receptors (GPCR), which are major drug targets (GPCRs represent 30% of current drug targets). The training proposed in this program will not only form high-level academic researchers but will also largely contribute in forming the main actors of the future developments in biotechnology and personalized medicine. This network combines 12 academic research groups and 3 industrial companies interested in collaborating with these groups and involved in drug discovery or scientific equipment for SBMP. These groups are internationally recognized for analysing the structure and dynamics of membrane proteins by a combination of experimental and theoretical approaches: in vivo and in vitro expressions systems, functional/biochemical/biophysical characterisation, X-Ray diffraction, electron microscopy (EM), atomic force microscopy (AFM), single-molecule force spectroscopy (SMFS), liquid and solid state NMR, numerical simulations. Seven partners from 6 dif