RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biophysical and structural studies on Wnt-regulatory complexes of LRP5/6, Dickkopf and Kremen' (Dickkopf), addressing dissemination and exploitation.

assistant: **Impact**

Orchestration of developmental processes as well as function and homeostasis of tissues depend on fine tuned intercellular communication, necessitating carefully controlled extracellular gradients of a wide range of signalling molecules. Signalling by the Wnt family of secretory glycolipoproteins is renowned for its crucial roles in embryonic development and tissue homeostasis and is subject to a multi-layered system of regulation. Conversely, dysregulation of Wnt signalling is implicated in developmental defects, degenerative diseases, and cancer. Dickkopf (Dkk) proteins are secreted regulators of canonical Wnt/β-catenin signalling, which compete with the Wnt morphogens for their coreceptors LRP5 and -6. A second class of cell surface Dkk receptors, called Kremen (Krm1 and -2), amplify Dkk function by promoting cell surface expression of LRP5/6 in the absence of Dkk and inducing a rapid internalization in its presence.The goal of this proposal is to elucidate the molecular mechanisms behind the Wnt-regulatory activity of Dkk and Krm. I will use protein produced by transient secretory mammalian expression to reconstitute binary and ternary complexes of LRP5/6, Dkk, and Krm in vitro. A wide range of biophysical methods including analytical ultracentrifugation and surface plasmon resonance will be applied to characterize complex formation with respect to stoichiometry, minimal functional modules, affinity and kinetics. X-ray crystallization and electron microscopy will be used to study the structures of isolated complex components and the structural changes associated with complex formation. Based on biophysical and structural data, functional mutants of the proteins will be created and tested in a cellular setting using e.g. a Wnt-responsive bioluminescence reporter assa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smart fire-retardant coatings based on intumescent nanocomposites' to be submitted under Seventh Framework.

assistant: **Abstract**

In Europe, annual fire losses reach 80 billion €, meaning more than 1% of EU GDP, 4000 people die and another 80000 suffer terrible burns. The use of fire retarding intumescent coatings play an important role in Fire Safety being this subsector mainly comprised by SMEs.  Nowadays, a variety of fire intumescent coatings is available presenting diverse drawbacks such as: poor behaviour when ageing, poor liquid stability, heat blocking and smoke suppressant properties. Intumescent coatings are obtained by high loadings of reactive components which upon burning swell up creating a protective char layer. HEFEST project aims at developing new intumescent paints and varnishes by means of nanocomposite structures and nanofillers (hybrid organic-inorganic systems, carbon nanotubes…) obtaining halogen-free flame retardants as active intumescent components reactive from nanoscale, with the following advantages: •High durability during service-life (Fire resistance losses< 25% after ETAG 018-part 2 point 5.7.2.2 ageing test) •Liquid stability and easy appliance •Increased heat blocking and protection of the underlying substrate (FR≥90) •Good fire resistance behaviour in the protection of off-shore constructions (good hydrocarbon curve results) •Smoke suppressant properties (30% reduction in gas emission), limitation of spread of fire and smoke within construction works ( ETAG 018)  HEFEST counts on a well balanced consortium of 5 SMEs, 2 RTDs and a professional association specialized in organic coatings for the diffusion of the results.. SMEs have in common their conviction on innovation as the best tool to improve their competitiveness in a sector in which big multinationals are ever gaining market share. SMEs partners are complementary and cover the whole project necessities: fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quality Controlled Component-based Software development' in the context of a Fifth Framework call.

assistant: **Objectives**

Before Component Based Development will be accepted widely, the quality of the components needs to be guaranteed. Within QCCS we will develop a methodology and supporting tools that can guarantee that a component will perform as specified. Using the methodology will result in formal contracts for the components. Each contract refers to various quality aspects, related to syntax, behaviour, synchronisation, and performance. In the methodology we will use the Aspect Oriented Programming approach to specify each quality aspect separately. Specially designed Aspect Weavers will then weave these partial implementations together, such that the resulting integrated system fulfils a certain contract. We will test this methodology on two case studies and disseminate the results widely. We will actively take part in relevant de-facto standardisation bodies. We foresee to start a joint venture to exploit the results.Objectives:Contracts for software components are a novel way of guaranteeing their quality. It is a difficult task to design components that comply with contracts, because different problem dimensions or quality aspects have to be addressed at the same time. To overcome this, the QCCS project will develop a methodology and supporting tools for the development of components that is based on Aspect Oriented Programming. This implies that partial implementations will be developed, each addressing one single quality aspect of the component. These will be woven together by especially designed aspect weavers to a complete component, complying a certain contract. This new approach will be tested and evaluated on two real applications. The results will be disseminated widely, for instance by contributing to relevant de-facto standards. A final objective is to start the commerc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Social-Ecological Analysis and Models for Digital Twin Ocean' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The EU Mission ‘Restore our Ocean and Waters’ (Mission Ocean) aims at protecting and restoring the health of our ocean and waters through research and innovation, citizen engagement, and blue investments by 2030. The creation of the European Digital Twin Ocean (EU DTO) supports this mission as well as the key initiative of the European Commission, Destination Earth (DestinE), aiming at developing a highly accurate digital model of the Earth on a global scale to be able to monitor, simulate, and predict the interaction between natural phenomena and human activities. Addressing the Horizon Europe call HORIZON-MISS-2023-OCEAN-01-8, SEADITO focuses on the need for a targeted set of analytical methods and tools to support the development of the EU DTO including integrating social-ecological models in order to establish a comprehensive decision support platform. SEADITO aims at increasing transdisciplinary abilities of social-ecological models by updating and integrating them for improved Ecosystem-based Management, and a set of case studies in the Baltic Sea, the North Sea and the Mediterranean as well a Pan-European case study will provide the contexts for the multi-actor processes identifying user needs, as well as co-designing and testing components and services in the targeted user communities. The results will include sets of interoperable, spatial explicit, and DTO compliant social-ecological decision-support components based on FAIR principles (e.g. to be integrated with EDITO-Model Lab), as well as scalable and multi-level social-ecological models, integrated quantitative and qualitative social-ecological indicators, and workflows quantifying and integrating cultural and behavioural aspects. The components will be tested through an interactive spatial platform, the S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Identification of genes involved in cell reprogramming using micro-cell-mediated chromosome transfer'.

assistant: **Innovation**

Adult stem cells are able to differentiate into multiple cell types representing a compelling tool in cell-replacement therapy. However, they are a very limited cell population being not sufficient to be used for therapeutic purposes.Today the unique unlimited font of stem cells is constituted from the Embrionic Staminal (ES cells) isolated from embryos, although there are several ethical or legal impediments to experiment with them. To overcome these problems, one challenging strategy might be to de-differentiate fibroblasts isolated from skin biopsies. These undifferentiated cells could be re-implanted to provide a source of cells to correct a variety of defects avoiding also the complications of immune rejection.The goal of this project is to identify the chromosome(s) and then the gene(s) involved in the induction and/or maintenance of undifferentiated status. The identification of this gene(s) will let us express them in fibroblast cell lines in culture with the aim of de-differentiating them. Fusion between lymphocytes and embryonic germ cells (EG cells) results in de-differentiated hybrids that have lost the expression of markers of differentiation.Based on this evidence, I propose to create hybrids between differentiated cells and microcells that contain one or more chromosomes of EG cells using the microcell-mediated chromosome transfer technique. Dedifferentiated hybrid cell clones will lack markers of differentiation and have features of EG cells such as re-activation of X chromosome or loss of imprinting.Once the chromosome or the group of chromosomes driving reprogramming is identified, we will narrow critical genomic regions by transferring less than a whole chromosome to recipient cells, which will permit to find candidate genes implicated in dedifferenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Millimetre-wave magneto-optical studies of correlted electron systems' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The project aims to provide a detailed understanding of carrier-carrier interactions in low dimensional systems in order to gain information about fundamental physical phenomena such as superconductivity and magnetism. In addition organic molecular metals have long-term technological applications. This project involves collaboration with European academic and industrial research groups. In order to determine carrier-carrier interaction strengths in organic molecular metals, magnetooptical (cyclotron resonance), magnetisation and magnetotransport measurements will be performed. A comparison of the effective mass (quantum oscillations) and the dynamical mass (cyclotron resonance) will give the carrier-carrier interaction strength. To extend the techniques a tuneable resonant cavity plus higher frequencies will be developed and the experiments extended to high hydrostatic pressures. I shall gain complementary information about physical mechanisms in these novel materials by carrying out calculations of quantum oscillations and the magneto-optical response using computer models. Training content (objective, benefit and expected impact) I shall become skilled in scientific techniques such as cryogenics, high pressures and millimetrewave optoelectronics and will gather professional experience in computer modelling My communication skills will be improved by presenting my work at conferences In addition I will interact with the large number of experimental and theoretical scientists in Oxford Physics. Links with industry / industrial relevance (22) My project will have strong links with AB Millimetre SARL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'mechanisms of GABAergic interneurons axonal branching in developing cerebellum network'.

assistant: **Innovation**

The appropriate wiring of neuronal circuits in mammalian brain forms the basis to generate, integrate, and process patterns of neuronal activity, which underlie perception and cognition.GABAergic inhibitory circuits consist of an array of interneuron cell types with distinct morphology, physiological properties, and synaptic connectivity patterns, and may constitute a scaffold to organize local cortical connectivity and activity.A definite feature of GABAergic innervation is their specific axonal morphology and specific target cell and domain recognition, which allow precise spatial and temporal control of neuronal signaling, dynamics, and plasticity. Dysfunctions of GABAergic system have been implicated in a variety of neurological and psychiatric disorders such as epilepsy, schizophrenia, and depression.Although GABAergic connectivity is essential for the construction of functional cortical circuits, the formation and development of exquisite GABAergic axon branches in general are poorly characterized. The purpose of the current proposal is to follow the early events of interneuron neurites outgrowth and branching and to identify the molecules involved during this process using state of the art technical approches. The ultimate goal is to describe how environmental signals specifically shape and build functional neuronal circuit in relation to their genetic content.While physiologists are very well aware about the importance of GABAergic interneurons circuitry in regulating all the aspects of synaptic communication (i.e. input, integration and output as well as synchronization) of principal neurons, the cellular and molecular mechanism of GABAergic circuitry development remained unknown. This field is a new and almost untouched area that will brings new idea and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Universal Equilibrium and Beyond - Challenging the Richardson-Kolmogorov Paradigm' to be submitted under Horizon 2020.

assistant: **Abstract**

Turbulence is at a crossroads: The old, established ideas of Richardson and Kolmogorov have with accumulating evidence come under renewed scrutiny, especially in non-stationary and non-equilibrium flows. Many in the community seek new and more accurate ways to describe turbulence. This is a time of re-evaluation and opportunity!The assumed statistical equilibrium of the smallest and intermediate scales is identified as the main cause of the potentially erroneous deductions. This problem was not previously noticed because experiments that confirmed the previous theories were all in statistical equilibrium. And those experiments and theories which disagreed were labelled ‘anomalous’, no matter how carefully performed or argued.The proposed theory-intensive approach will therefore specifically use non-equilibrium and statistically non-stationary flows to:1. Investigate the underlying mechanisms determining the level of dissipation2. Quantify the resulting effects on the balance equations of central importance3. Test the results against the established, as well as competing, theoriesI will use stationary and accelerating jets well-suited for studying the non-linear interactions and quantifying departures to the assumed equilibrium and the non-stationary dissipation. The feasibility is demonstrated with preliminary results. The databases which will be established should contribute substantially to settling the long-lived ultimate question of turbulence: what are the true underlying mechanisms that set the level of dissipation.The results will be ground breaking scientifically and economically. The impact for engineering applications is extensive, since Kolmogorov-based turbulence models are routinely used, and since developing flows constitute the rule rather than the except
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Process-oriented Learning and Information eXchange' (PROLIX).

assistant: **Concept**

The major goal of PROLIX is to align people and processes in complex & dynamic working situations by addressing the needs of employees and companies at the same time.<br/>PROLIX develops an open, integrated reference architecture for process-oriented learning and information exchange. <br/>PROLIX supports a complete learning process life cycle comprising 1. the analysis of complex business situations; 2. the identification of individual and organizational learning goals; 3. the analysis of competencies and their matching with individual skills; 4. the definition of appropriate learning strategies and the simulation of learning processes; 5. the execution of improved learning processes; 6. the monitoring of learners' performance according to the goals defined.<br/>The key innovation in PROLIX consist of a process- and competency driven framework for interlinking business process intelligence tools on the one hand with knowledge management and learning environments on the other. <br/>In order to demonstrate its concept, PROLIX sets up three test beds in different fields of application. In the first 18-month period, PROLIX will specify, design, implement and start to demonstrate its tools and services in more mature eLearning-aware and, therefore, lower risk environments, i.e. the Government test bed" with UK Government Care Programme (Social Care Institute for Excellence), the "Telecom test bed" with British Telecom (BT) learning, and the "Educational Publishing test bed" with publishing houses Klett and EDITIS.<br/>To reach the objectives, PROLIX unites 19 partners from 10 different countries made up of the 2 leading and largest European software vendors for Learning Management (imc Germany) and Learning Content Management (Giunti Interactive), the largest independent Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hyperbolic and kinetic equations: asymptotics, numerics, applications' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

In view of its central position in modern applied science, an applied mathematics approach which integrates modeling, analysis, and numerics in the field of hyperbolic and kinetic equations is a key training ground for young applied mathematicians. Such training will be an excellent starting point for academic as well as nonacademic, industrial careers. All the network groups already have a long international experience in training young applied mathematicians at the M. Sc., Ph. D., and post doc level. This experience will be used to make sure that workshops, meetings, and other network activities not only produce good science but really meet the training needs of the younger network participants. The industry aspect of the training will be enhanced by the excellent industry relations of several key members of the network as well as by the advice of the Industrial Advisory Board.