RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'When your enemy becomes your friend: Evolution of the interaction between fungi and land plants' under Horizon Europe.

assistant: **Concept**

Plants live in close association with microbes, establishing interactions that range from beneficial to detrimental. Molecular plant-microbe interactions have been extensively studied in flowering plants, whereas research in non-seed plant lineages has been hindered by the lack of pathosystems reflecting natural plant-microbe interactions. My team and I identified the first example of a fungus that establishes opposite interactions with flowering and non-seed plants. We discovered that the fungus Trichoderma, which promotes plant growth, defense, and stress tolerance in flowering plants, is pathogenic for other land plant lineages (non-vascular plants and ferns) indicating unexpected differences in land plant immunity and fungus behavior. The overarching goal of our project FRIENEMIES is to decipher the molecular evolution of plant-microbe interactions from pathogenic to beneficial across land plants. In FRIENEMIES, my team and I will characterize the molecular mechanisms involved in disease in non-seed plants using three genetically tractable non-seed model plants (two bryophytes and the C-fern) and a diversity panel of sequenced Trichoderma strains where we will identify fungal effectors, plant susceptibility and resistance genes and signaling pathways relevant for pathogenic interactions. Combining omics, reverse genetics, natural variation, and phylogenetic analyses we will reveal the conservation of susceptibility/resistance mechanisms in other plant lineages and determine the emergence of mutualistic interactions between Trichoderma and land plants. We envision that FRIENEMIES will describe fundamental differences in immunity across land plants, discover potentially novel and conserved molecular mechanisms mediating plant-microbe interactions, define their evoluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bose-Einstein Condensation of Ground State Molecules'.

assistant: **Objectives**

The aim of this project is to create a Bose-Einstein Condensate (BEC) of ro-vibrational ground state molecules. A BEC of molecules in the ro-vibrational ground state can be used as a “molecular matter wave laser”. It will serve as an ideal starting point for the investigation of collisional processes in the zero-temperature limit and for the study of fully coherent chemical processes. It will be a bright and extremely narrow-band source for precision molecular spectroscopy, and it will provide a testing ground for elaborate strategies to form condensates of more complex molecular systems. This project is intended to bridge the boundaries between atomic, molecular and condensed matter physics with strong linking to the newly emerging field of ultracold chemistry.  The project proposes a specific route to produce a BEC of ro-vibrational ν=0 and J=0 ground state Cs2 dimer molecules by taking weakly bound molecules associated on a Feshbach resonance and transferring them to the ro-vibrational ground state of the singlet molecular potential using two stages of optical two-photon transfer. For this an optically trapped BEC of Cs atoms is first loaded into an optical lattice to form a Mott insulator state with precisely two atoms per lattice site. Weakly bound dimer molecules are then formed out of the atomic Mott insulator state by means of the Feshbach association technique. Confinement at each lattice site shields the molecules from inelastic collisions until they are transferred to the ground state. Optical transfer is achieved by the STIRAP technique using phase-locked diode lasers referenced to a frequency comb. Two successive stages of STIRAP are need to bridge the internuclear distance and to remove a binding energy corresponding to about 3650 wavenumbers. After the tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Next generation additively manufactured magnesium alloy scaffolds for bone generation' in the context of a Horizon Europe call.

assistant: **Objectives**

Porous scaffolds (i.e., lattice implants) play an important role in bone regeneration since they can mimic the structure of bone, bond to bone and in some cases stimulate bone growth. To date, most clinically approved porous scaffolds are limited to those fabricated from non-degradable metals. As such, a second surgery is often required to remove them once their purpose is fulfilled. This is often a burden for the patient and results in significantly increased health care costs. Biodegradable Mg alloys can overcome these issues thanks to their ability to dissolve within the human body while being replaced by new bone tissue. The aim of this project is to advance the potential use of Mg alloy porous scaffolds for bone grafting applications. To achieve this aim, the proposed research seeks to fulfil three primary objectives: (1) to design a next generation biomedical Mg-Zn-Ca alloy suitable for laser-powder bed fusion processing (L-PBF) of porous scaffolds; (2) to improve the mechanical and degradation properties beyond those of ‘benchmark’ commercially available biomedical Mg alloys; (3) to incorporate biodegradable polymers into porous Mg-Zn-Ca-based lattices as a means of improving the functionality of the lattice implant. The project seeks to combine the in-depth material knowledge and industrial experience of the Experienced Researcher (ER), with the biomedical expertise, wide subject background and extensive collaboration networks of the supervisor, Cecilia Persson, along with the broad range of infrastructure available at the host organisation, Uppsala University. The interdisciplinary aspect of the proposed research will enable the ER to expand his knowledge in several areas and will substantially improve his career prospects, especially given the supervisor’s exc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modulating Drug Transporters Dynamics to Improve Therapeutic Efficacy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The therapeutic effect of a drug is largely determined by how effectively it reaches its site of action. Drug distribution in the human body is defined by an intricate network of transporters, offering potential for dynamically controlling where a drug spends most of its time. DynamITE aims to provide the tools to manipulate this ""highway network"" of drug transport at will. DynamITE will exploit the common mechanism shared by transporters, that is the alternating-access. Every transporter must dynamically switch between different states to enable directional transport of its substrate through the biological membrane. At the molecular level, this involves important local and global changes in the protein's three-dimensional structure. The foundational methodology of DynamITE is a structural mass spectrometry approach that reports on such changes: hydrogen-deuterium exchange coupled to mass spectrometry (HDX-MS). I have demonstrated that HDX-MS can fingerprint the effects of drugs on the dynamic switching between states. DynamITE builds on this knowledge to identify and design modulators of transporter dynamics. A modulator that prevents the conformational changes underlying transport will block drug transport, while a modulator that increases the rate of conformational transitions will accelerate transport.DynamITE’s approach will be applied to selected drug transporters with proven critical roles in antibiotic resistance, drug toxicity, and drug transport into the brain. In parallel, DynamITE will advance the HDX-MS technique to make it applicable to living cells. Such a development will enable the observation of protein dynamics in cellulo, with a molecular level of resolution—something currently inaccessible. This methodological breakthrough be used to monitor drug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cystic Fibrosis: A Model Disease to Set Up Procedures for Cost Effective Genetic Testing and Counseling in the EU' (1994-1998).

assistant: **Concept**

Cystic Fibrosis (CF) provides a unique model to study various aspects of genetic testing, counselling and medical care. Indeed (1) mutation screening and counselling have been available in most EU countries for a number of years and in many laboratories; (2) the frequency of carriers is high ( 1/20-1/30); (3) facilitated contacts between the research community, the clinical geneticists and the medical practitioners have been set up e.g. through the past and ongoing CA on cystic fibrosis. The present proposal aims at: (1) developing high quality procedures for genetic testing and counselling. This will be achieved by testing and training in laboratory methods, providing quality supplies, and by developing sets of information documents and forms for the practitioner and the patient, (2) stimulating the registration of medical and genetic information in a robust internationally compatible database adapted to the needs of clinicians and researchers, (3) providing support for research on genetic factors which modulate the phenot of cystic fibrosis. More facilities will be responsible for the coordination, for the training of pilot centers and for the supplies and documents. The pilot laboratories in turn will train and support regional and local testing and counselling centers. The same network will be used for the testing and implementation of the clinical database and for the research on genetic factors which modulate CF symptoms. During the course of this CA, the steering committee will receive counsel from experts in legal and health economic matters regarding this CA and will stay in close contact with the gene therapy centers who in turn should benefit from the information obtained by this CA. At the end of this concerted action, a series of guidelines for the accredit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Broadband Access High data rate Multimedia Satellite' (BRAHMS) targeting Fifth Framework.

assistant: **Abstract**

The aim of the BRAHMS project is to define and develop a universal user access interface for Broadband Satellite Multimedia services, which is open to different satellite system implementations. The motivation is to open up and expand the market for satellite user terminals by harmonising the majority of common satellite access network functions whilst allowing flexibility for optimised or proprietary air interfaces to satellite systems. The targeted end-user markets for Broadband Multimedia Satellite Systems (BMSS) are mainly those where high speed access is at a premium. Two-way transmission for Direct-to-Office or Direct-to-Home multimedia services will be addressed with bit rates up to 150 Mb/s (forward link) and 20 Mb/s (return), providing the end user with an effective bandwidth that improves upon state-of-art multimedia systemsObjectives:The objective of BRAHMS is to define a universal user access interface for Broadband Satellite Multimedia Services which is open to different satellite system implementations, including GEO and LEO constellations.The rationale for this approach is to open up and expand the market for satellite user terminals, and for satellite systems in general, by harmonising the majority of common satellite access network functions whilst allowing flexibility for optimised or proprietary air interfaces to satellite systems. This commonality and flexibility (e.g. for frequency, access type, orbit) is obtained by separating physically-related functions from common service and access functions.The concept is dubbed the Broadband Multimedia Satellite System (BMSS) and aims to address a range of multimedia user groups with data rate requirements up to 150Mb/s. This BMSS approach is seen as a vehicle for convergence between fixed and mobile multimed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COMBINATIONAL USE OF INNATE IMMUNE RECEPTORS FOR CANCER IMMUNOTHERAPY' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Cancer is a major scientific and economical challenge that our society has to face and new therapeutic approaches should now be evaluated in order to decrease human and financial cost of this disease. After suffering from many drawbacks, cancer immunotherapy, which aims at mobilizing the immune system to fight cancer, has recently gained enthusiasm with the completion of several randomized phase III clinical trials. Because of their ability to trigger the innate immune responses, ligands for pattern-recognition receptors (PRRs) have been included in several vaccination protocols. These approaches, however, have unveiled new hurdles. Here we propose to investigate a new approach for cancer immunotherapy in Human, based on the use of PRR ligand-containing tumor cells. We have recently shown that introducing the bacterial protein flagellin into tumor cells stimulates innate immune cells and induces a tumor-specific adaptive immunity. Flagellin recognition by myeloid cells engages three distinct PRRs, but subsequent molecular mechanisms controlling presentation of tumor-associated antigens to T lymphocytes are still poorly defined. In addition, the precise nature of adaptive immune responses that efficiently eradicate tumor cells still needs to be precisely characterized before developing pre-clinical trials in Humans. In this context, flagellin-expressing tumor cells represent a powerful tool to uncover fundamental questions on the control of the adaptive immunity by the innate immune system, which will be necessary for the development of new anti-tumor immunotherapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimized Up-scaled Technology for next-generation solid OXide electrolysis' to be submitted under Horizon Europe.

assistant: **Abstract**

The main aim of OUTFOX is to remove scale as limiting factor in the deployment of SOEL technologies, while proving their potential to become the preferred option for green hydrogen production. By combining experimental results up to 80 kW scales with identification of optimal cell and system designs, OUTFOX will prepare SOEL for industrial scale systems of 100+ MW with an LCOH as low as €2.7/kg hydrogen and applicability to mass manufacturing lines.The industrially-driven OUTFOX consortium will combine expertise on cell, stack and module development, manufacturing, and full system evaluation to advance the maturity of SOEL and contribute to the targets of the Clean Hydrogen JU SRIA. OUTFOX will achieve current densities of at least 0.85 A/cm2 through the use of cells with 25% less thickness than  current high volume state-of-the-art, improving sustainability through reducing total materials requirements. Scale-up will be approached from two sides: (1) development and validation of cells with geometric areas up to 800 cm2 that are compatible with at-scale manufacturing techniques, and (2) validation of optimized design concepts with increased numbers of stacks per module. The partners will validate high current density operation with reference scale (144 cm2), industrial scale (>300 cm2) and next-generation cells (900 cm2) in single repeating units, short stacks of 15 cells, and 80 kW prototype systems, leading to more than 10,000 hours of SOEL operation. Two separate 80 kW testing campaigns with two different stack configurations and a total of more than 4000 operating hours, to be tested onsite at the Shell facilities in Amsterdam, will go beyond the scope of the call text to provide a comprehensive validation of the OUTFOX technology, thus providing key data for desig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative Social and Employment Policies for Inclusive and Resilient Labour Markets in Europe' (INSPIRES).

assistant: **Innovation**

The INSPIRES project aims to contribute to resilient and inclusive labour markets in Europe. It comparatively assesses the resilience and inclusiveness of labour markets in European countries, it identifies innovative policies that have contributed to resilience and inclusiveness and it analyzes strategies of policy learning that facilitate the development and transfer of these innovations within and across European nation states. In order to do so, it analyzes in-depth the evolution of labour markets policies, employment policies and social policies. Moreover, it qualitatively and quantitatively assesses the labour market position of vulnerable groups from 2000 onwards. INSPIRES covers eleven countries from all European welfare traditions: Mediterranean, Eastern-European, Anglo-Saxon, Scandinavian and the continental regimes. The consortium consists of a multidisciplinary team of leading European scholars that focus on the labour market, employment issues and social policies.The INSPIRES project aims to accumulate practice-oriented knowledge on the factors that positively and negatively affect resilience and inclusiveness. It seeks to explain differences within and between countries, and within and between the labour market positions of different vulnerable groups on the labour market. INSPIRES intends to isolate the impact of national policies from the structural demographic, social and economic characteristics on labour market resilience. Building upon this analysis, it tries to identify processes of policy learning and innovation that occur in the interactions between policy makers, politicians, non-profit organizations, trade unions, business associations and other stakeholders at the European, national and regional level. The outcomes of INSPIRES contribute to fac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EuroNanoForum2005 - 'Nanotechnology and the Health of the EU Citizen in 2020'' (ENF2005).

assistant: **Innovation**

This SSA is for support for a 5-day conference on the theme 'Nanotechnology and the Health of the EU Citizen in 2020' from 5-9 September 2005 in Edinburgh. It is being organized by The Institute of Nanotechnology.It will build on the success of EuroNanoForum2003, and promote developments in nanotechnology that are leading to innovative solutions for health and healthcare in Europe as part of an integrated and responsible approach. The format will be a combination of thematic workshops, public debate, forums, and conference showing the state-of-the-art.EuroNanoForum2005 is forming a prestigious element of the UK's 6th Presidency of the EU, which runs from Juneto December 2005. It will also be timely in terms of reinforcing the EU policy for research funding fornanotechnology and converging technologies in the Seventh Framework Programme.EuroNanoForum2005 will explore several critical issues, such as the ongoing competitiveness of the Europeanhealthcare industries; meeting the demands of an ageing population, the early diagnosis and potential cures, forexample, of cancer, cardiovascular disease and inflammatory diseases. It aims to demonstrate the potential ofnanotechnologies to address these issues, support the creation of high quality jobs, and underpin important EUobjectives such as the Lisbon Agenda.To achieve its aim, EuroNanoForum2005 will promote exchanges on groundbreaking European research innanotechnologies as applied to healthcare, bringing together key industrial players, academia, and policymakers, in an international context.Key themes include:- A review of EU research progress since 2003- A look to FP7, and the role of convergent technologies in the EU strategy for healthcare- New developments in tissue engineering; targeted drug delivery; biomaterials; ana