RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Transnational Network for Social Innovation Incubation'.

assistant: **Innovation**

Transnational Network for Social Innovation Incubation – TRANSITION – is a 30-month project that supports the scaling-up of social innovations across Europe by developing a network of incubators which brings together established partners within the fields of social innovation (SI) and innovation-based incubation (IBI). TRANSITION will also provide learning output on which scaling methodologies are most effective in a given region and the level of impact of these methodologies when transferred between regions.TRANSITION is led by the European Business & Innovation Centre Network (EBN), Europe’s network of innovation-based incubators, and The Young Foundation, a pioneer in the field of SI. Additional partners in the consortium provide a broad geographical spread for the Scaling Centres (in France, Ireland, Italy, Portugal, Spain & the UK) and a diversity of approaches to SI and IBI which will ensure a wide range of methodologies will be tested, analysed and shared.TRANSITION will identify a pool of 300 SIs with the potential for scaling. This sourcing phase will combine 6 widely-promoted 1-day Spark Sessions, with local searches by partners using their own extended networks. From the pool, selected SIs will be given support within the Scaling Centres covering design, financial, legal, social impact value & enhancement, & business coaching to help them scale nationally & internationally. If appropriate, SIs will be passed between Scaling Centres during this process. For example, an Italian SI may find opportunities to work in UK and the two Scaling Centres will jointly provide co-incubation support for the transition.A final strand of activity will develop a “fast track” Start-ups Lab to rapidly take SIs at the ideas stage all the way through to international implementatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancing immunotherapies against solid tumors with TLR-switch receptor-armored T cells (TLR-T cells)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Immunotherapy, particularly adoptive T cell therapies (ACT), has revolutionized cancer treatment, providing significant benefits to patients with haematological malignancies. Despite these successes, their effectiveness against solid tumors remains limited. A major unaddressed obstacle in treating solid malignancies with ACT is the suppression of T cells within the tumor microenvironment (TME), which hampers their sustained activity against tumor cells. Thus, there is a critical need to optimize these therapies to be effective against a wider range of cancer types. One promising approach involves engineering adoptive T cells with switch receptors (SRs) that convert the detection of extracellular suppressive signals into intracellular T cell activation. Damage-associated molecular patterns (DAMPs) are endogenous ‘danger’ ligands and powerful innate immune agonists that signal through Toll-like receptors (TLRs) to various cell types, playing an essential role in mounting protective immunity. However, the potential to utilize these innate immune signals to empower therapeutic T cells remains unexplored. This research proposal aims to enhance ACT against solid tumors by leveraging innate immune signals to improve T cell function within the suppressive TME. Specifically, the goals are (1) to design innovative SRs that amplify TLR costimulatory signalling upon detecting TME immunosuppressive factors, and (2) to incorporate these SRs into T cells, evaluating their therapeutic potential in both TCR-T and CAR-T therapies using complementary murine and human tumor models. By harnessing innate inflammatory signals, the proposed strategy seeks to boost fitness, cytotoxicity, and resilience of infused T cells, enabling them to navigate and function more effectively within the immuno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A miniaturized system to secure the cold chain' (TEMPIX).

assistant: **Innovation**

We have developed an affordable and easy-to-adopt way of securing cold chains: Tempix time-temperature smart labels. Our labels guarantee that products are handled at the correct temperature throughout the entire cold chain. If the product is exposed to conditions above the stipulated temperature for an extended period, the bar code will be blocked rendering it unsellable. We provide a complete turnkey solution comprising a 2- in-1 thermal label printer and a cover label applicator. The market has welcomed our innovation. Nowadays, Tempix labels secure LIDL’s fresh fish cold chains in Finland. Furthermore, we are running pilots with other prestigious companies around the world. For all its virtues we are aware of the limitations of our solution. Tempix printers are big and require compressed air to operate. These factors restrict our targeted users to major primary food producers and factories with large single story floor space. For Tempix technology to reach its full potential, it is necessary to develop a desktop-sized version of our system. To scale up, we must scale down. In this Phase 1 study, we will scout for the most suitable technology and manufacturing partner to achieve miniaturisation. Simultaneously, we will develop a strategy for market deployment.


**Keywords:** Cold chain, food waste, last expiry date, temperature control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Four dimensional microtectonics: quantifying complex deformation paths through time in natural shear zones deformed by general shear'.

assistant: **Innovation**

Movement along faults is a direct response to deformation of the Earth's strong outer shell (the lithosphere), and the main cause of earthquakes. The displacement of lithospheric plates across the Earth's surface is typically accommodated within localized deformation zones such as brittle faults or ductile shear zones. If we are to predict when faults move and by how much, we need to understand the fundamental processes that govern this deformation. As displacement in brittle faults near the earth's surface is linked to ductile flow in shear zones at depth, it is critical to understand the evolution of ductile, deep-crustal shear zones in both space and time. Yet, the mechanisms behind partitioning of deformation into structures that accommodate different types of displacement are not well understood, and recent work has shown that tools and concepts used for studying shear zones are inadequate in a very common, complex type of shear zone deformation (transpression). What is needed now is a new micro-kinematic approach that will make it possible to track the three-dimensional evolution of faults and shear zones through time (i.e., 4D micro-tectonics).This process-based study aims to constrain the 4D kinematic history of transpressional shear zones by a multi-disciplinary approach, integrating a variety of geological analytical techniques with a novel method employed in materials science (Electron BackScatter Diffraction or EBSD). The outcome will be a well-constrained, field-based model for evolution of crustal-scale transpressional shear zones and the development of a novel integrated, quantitative methodology for micro-kinematic analysis of deformation. The proposed fellow will gain hands-on expertise in state-of-the-art analytical techniques, and the project may act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Overcoming plant graft incompatibility by modifying signalling and perception' (GRASP) targeting Horizon 2020.

assistant: **Abstract**

For millennia, people have cut and joined together different plants through a process known as grafting. Plants tissues from different genotypes fuse, vasculature connects and a chimeric organism forms that combines desirable characteristics from different plants such as high yields or disease resistance. However, plants can only be grafted to closely related species and in some instances, they cannot be grafted to themselves. This phenomenon is referred to as graft incompatibility and the mechanistic basis is completely unknown. Our previous work on graft formation in Arabidopsis thaliana has uncovered genes that rapidly activate in grafted tissues to signal the presence of adjoining tissue and initiate a vascular reconnection process. These genes activate around the cut only during graft formation and present a powerful tool to screen large numbers of chemicals and genes that could promote tissue perception and vascular formation. With these sensors and our previously established grafting tools in the model plant Arabidopsis, we can address fundamental questions about grafting biology that have direct relevance to improving graft formation through:1. Identifying genes required for the recognition response using forward and reverse genetic screens.2. Determining and characterising signals that activate vascular induction using a chemical genetics screen.3. Characterising the transcriptional basis for compatibility and incompatibility by analysing tissues and species that graft and comparing these to tissues and species that do not graft.4. Overcoming graft incompatibility and improving graft formation by applying the knowledge obtained from the three previous objectives.We thus aim to broaden our fundamental understanding of the processes associated with grafting inclu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Children Hybrid Integration: Learning Dialogue as a way of Upgrading Policies of Participation' (CHILD-UP), addressing dissemination and exploitation.

assistant: **Impact**

CHILD-UP researches the social conditions of migrant children’s integration through social participation, taking in primary account gender differences, legal status and age groups. , with the final aim to propose an innovative approach to understand and transform their social condition.  First specific objective is providing  an European overview, collection of data and evaluation concerning children’s conditions of living, protection and education. In selected contexts in seven countries, the research focuses on: (1) policies and practices of integration in schools, reception centres, social services and communities; (2) children’s and parents’ experiences, perceptions and expectations of integration;  (3) specific practices of language teaching, facilitation of dialogue, intercultural education and mediation. Second objective is providing support for migrant children’s exercise of agency in changing their own conditions of integration and constructing hybrid identities. This objective can be achieved through the promotion of a dialogic system of practices, in schools and in their relations with partners (social services, reception centres, education and mediation agencies) and families. The project provides: (1) guidelines for dialogic activities in schools;  (2) written and online training packages for teachers and other professionals; (3) a package for self-evaluation of activities. These tools will support co-action of teachers and other professionals, and coordinated planning between schools and their partners. Third objective is informing policies at the local, national and European level through dissemination and exploitation of research outcomes and tools. This objective can be achieved through the collaboration of three consortium partners, international and l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Immunopathogenesis of Addison's disease and related disorders' (1994-1998).

assistant: **Innovation**

1) identification of new autoantigens in adrenal gland and in the gonads 2) identification of B-cell epitopes in the autoantigens and subsequent development of diagnostic tests, 3) characterisation of the helper T-cell and cytotoxic T-cells responses toward adrenal and gonadal autoantigens and identification of the corresponding T-cell epitopes, 4) analysis of the HLA background of various forms of Addison's disease and the study of HLA T-cell peptide interaction with molecular modelling, 5) search for immunological cross reactivity between Candida albicans antigens and adrenal and gonadal autoantigens, 6) generation of animal models for Addison's disease for immunotherapeutic studies and 7) the study of 21-hydroxylase antibodies in related autoimmune diseases.Autoimmune Addison's disease, the main course of adrenocortical failure in the developed world is characterised by an immune response against adrenal cortex and in some instances against other steroid hormone-producing cells as well. Recently, our groups have shown that the target antigens in the adrenal cortex and the gonads are members of the steroidogenic enzymes, notably 21-hydroxylase (P450c21), 17-hydroxylase (P450c17) and the side-chain cleavage enzyme (P450scc). These studies > will now be continued in a co-ordinated manner with the objectives stated above: 1) New autoantigens will be identified by screening adrenal or gonadal expression libraries 2) B-cell epitopes in the autoantigens are looked for by the Pepscan method 3) Helper T-cell and cytotoxic T-cells epitopes are identified using synthetic soluble peptides, 4) The HLA background of various forms of Addison's disease will be studied 5) Candida albicans expression libraries are screened with patient sera and with monoclonal antibodies to the identi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'STRATIFIED HOST-DIRECTED THERAPY FOR DRUG-RESISTANT TUBERCULOSIS: A RANDOMIZED CONTROLLED MULTI-CENTRE TRIAL' (DRTB-HDT) targeting Horizon 2020.

assistant: **Abstract**

Tuberculosis is a leading cause of morbidity and mortality worldwide. Current TB treatments are inadequate, requiring patients closely adhere to multi-drug regimens that are long, complex, and often poorly tolerated. These concerns are greatly magnified in rifampicin-resistant (RIF-R) TB, an urgent global and EU public health priority. WHO estimates that only 54% of patients who began RIF-R TB treatment in 2016 were cured. In addition to these well-recognized shortcomings, current TB treatments, particularly those for RIF-R TB, leave a majority of cured patients with permanent, clinically significant lung impairment and radiographic evidence of bronchiectasis and fibrosis. This project will determine if two adjunctive host-directed therapies (HDTs) can prevent these poor outcomes. 330 patients with RIF-R TB and baseline risk factors for poor outcome will be enrolled in a randomized, controlled, 3-armed multi-centre trial, with clinical sites in Romania, Moldova, Georgia, Mozambique, and South Africa. All patients will receive standard multidrug therapy according to national guidelines. Those patients randomized to the experimental arms will in addition receive either CC-11050 or metformin. These selected HDT candidates represent 2 complementary HDT strategies: reducing inflammation vs inducing host cell anti-microbial activity, respectively. Both candidates are supported by data from preclinical and clinical studies. Co-primary efficacy endpoints will examine effects on lung function (measured by spirometry) and infection (measured as time to stable sputum culture conversion). A sub-study will examine quantitative change in lung radiodensity by CT scan.  If successful, this ground-breaking project will increase Europe’s capacity to control RIF-R-TB by developing new tre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS' under Horizon 2020.

assistant: **Concept**

Spinal cord injury (SCI) is a devastating pathology with dramatic lifetime consequences affecting thousands of people worldwide. Therefore, and considering the very limited regeneration ability of the central nervous system, in this project we propose to develop a neural tissue engineered scaffold capable of not only combining fibrous and porous topographic cues in order to mimic the morphology of the native spinal cord, but also potentiating the properties of graphene related materials (GRM) supported in a protein-rich decellularized matrix (adECM). In fact, the suggested 3D microenvironment should present electrical, chemical, mechanical and topographic features able to preserve neural cell survival and enhance neural progenitor cell differentiation towards neuronal and glial cells. Progress in this sense will contribute to a better understanding of the key factors controlling repair in damaged neural tissues and, consequently, bring insights into new therapeutic approaches for spinal cord recovery.


**Keywords:** Spinal cord regeneration,  tissue engineering,  graphene related materials,  embryonic neutral, progenitor cells, in vitro and in vivo testing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiscale Analysis of AiRframe Structures and Quantification of UncErtaintieS System' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MARQUESS has been specifically designed to address the challenges outlined in the Topic Description reference JTI-CS2-2016-CFP04-LPA-02-15 to fit into the activities of WP2.4.3 in the LPA IADP in Clean Sky 2. MARQUESS will serve as a valuable precursor to the above as it will enable comprehensive modelling and simulation studies to optimise decision making regarding the structural design of aircraft platforms. The outputs from this project will be applied to two Clean Sky Demonstrators to illustrate the benefits of multiscale modelling, whereby detailed models can be analysed and easily interprested by designers without having to undertake the same levels of effort and computational resource as one would have to if performing detailed modelling and simulation of the whole structure.UNOTT has vast experience of performing such work with projects analysing a range of aircraft components ranging from Aero-engine parts and structures through to landing gear components and bulkheads in major aircraft development programmes including both composite and metallic materials.Results from MARQUESS will deliver outstanding benefits for Europe on three levels. •On the commercial level, aircraft designers will be able to use the methods and tools based on the holistic multi-scale modelling techniques being integrated and developed in the project to enhance their competitive offering•On the societal level, the modelling framework will provide quantitative justification that will enable the design of more environmentally friendly aircraft, which will bring benefits in terms of reduced pollution and even enhanced mobility as there will be better scheduling of aircraft maintenance resulting in more reliable operation•On the scientific and technical level, where systematic integration of