RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanoregulation of alternative splicing - a multi-omics and single cell approach to improved cardiac function' to be submitted under Horizon Europe.

assistant: **Abstract**

To adapt cardiac function in response to mechanical load, a network of splice factors concertedly regulates multiple target mRNAs that affect biomechanics, electrical activity, metabolism, signaling, and growth. It includes the splice regulator RBM20, with mutations causing severe cardiomyopathy, as well as its substrate titin, whose >350 exons are differentially joined to adjust the elastic properties of the sarcomere and thus ventricular filling. In the spliceosome, diverse RNAs and RNA binding proteins interact in macromolecular complexes, but how their activity is regulated to adapt cardiac isoform expression and sarcomere mechanics has remained elusive.We have adapted localization proteomics to study macromolecular complexes in vivo at physiological expression levels, which has previously not been possible. Our titin-BioID knock-in mice have provided the first census of the sarcomeric proteome and uncovered a previously unknown connection between sarcomeric mechanotransduction and mRNA processing in the nucleus. This unexpected link is the basis of our hypothesis that altered strain of the titin filament is communicated to the nucleus where the spliceosome adapts titin isoform expression to adjust sarcomere elasticity. This proposed regulatory feedback loop would elegantly resolve the question of how sarcomeres adapt to mechanical load.Here, we will explore how the mechanoregulation of cardiac splicing contributes to heart disease in a functional multi-omics approach and develop technologies that combine single cell isoform sequencing and  mechanics to examine how heterogeneity of the mechanical microenvironment determines isoform expression in the individual cardiomyocyte.The overall scientific goal of the proposed work is to investigate the functional interaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Activation of Hydrogen by Organic Frustrated Lewis Pairs. Applications in catalysis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Activation of H2 is typically a domain of transition metal catalysis -even nature uses metal-centred reactions for this process. However, very recently Stephan and Erker have described metal free systems able to activate dihydrogen by the use of Frustrated Lewis Pairs (FLP), a combination of sterically hindered Lewis acids and Lewis bases that for this geometric reason are not able to quench each other. Moreover they were able to apply these systems for the reduction of some imines using H2 directly instead of any organic surrogate.Although this process is quite interesting, its applicability is nevertheless quite limited. Only silylenol ethers and very bulky imines can be satisfactorily reduced, non-encumbered ones simply react directly with B(C6F5)3, the ubiquitous  Lewis acid used to form FLPs.  To circumvent this obvious drawback I propose a new approach consisting in the use of completely organic molecules such as electron-poor allenes, alkenes, iminium salts and ketones as attractive alternatives to B(C6F5)3. The development of a totally organic FLP able to activate H2 reversibly goes far beyond the state-of-the-art as it is expected to allow the reduction of carbon-carbon and carbon-heteroatom double bonds without the use of any metal and employing directly H2. This wide-ranging extension of the FLP reactivity will clearly surpass classical metal catalysis in environmental issues as no noble metal will be necessary. Also, organocatalytic reductions will be outstripped in atom economy criteria as H2 and no heavier surrogate will be used as reducing agent.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gender, emotions and national identities: a new perspective on the abortion debates in Italy (1971-1981).' under Horizon 2020.

assistant: **Concept**

The proposed project focuses on the public debate (1971–1981) around Law No. 194, which liberalised abortion in Italy. It reconstructs the demands and actions of feminist groups and women’s associations, and analyses the discursive practices implemented by the various political cultures involved. The project aims to go beyond the parliamentary debate, and in doing so it will examine the social and cultural impact of an epoch-making law, as well as study the use of emotions and the elaboration of gender models and national identities. To reach these goals, the ER will resort to a classical methodology (cultural history of the political) but will apply it to an entirely new set of sources and to actors hitherto neglected in historiography.   This innovative research project will allow the Experienced Researcher (ER) to engage in an international research network, to expand her expertise and plan the next steps of her career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cancer in NIS Population after the Chernobyl accident' in the context of a Fourth Framework call.

assistant: **Objectives**

Foreseen ResultsThe aim is to stimulate further improvement of the systems, facilitate and support use of the data - including descriptive analysis, stimulate and assist in linkage of data to relevant files - e.g. Chernobyl Registers to identify cancer cases for specific studies.The specific objective of these studies is to estimate the radiation induced risk of leukaemia and NHL and of thyroid cancer among liquidators of the Chernobyl accident residing in Belarus or the Russian Federation and, in particular, to study the effect of exposure rate.The proposed project is within the field of health and dealing with investigating the health consequences of radiation exposure of populations in the NIS following the accident at the Chernobyl nuclear power plant. The studies are concerned with cancer risk in the general population making use of existing dose-reconstruction for geographical areas, and a specially designed analytical study (case-control) including interview and biological sampling among Liquidators.Work package 1The objectives is to improve and use epidemiological tools (Health Monitoring Systems) in the NIS with a view to consequences related to mastering the Chernobyl accident late-effects. The routine monitoring systems thus represents an unbiased and with respect to general exposures, the relevant comparison to which all population based radiation studies in the affected areas should compare.Work package 2Results of pilot studies carried out under ECP-7 indicated that it is feasible to carry out case-control studies of specific cancers among liquidators. Because there was an official limit to the dose liquidators were allowed to receive, some workers received their dose in a matter of minutes, while others received it over months or even years, and the predo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Feelings and Emotions: The Amsterdam Symposium.'.

assistant: **Objectives**

A 4-day symposium is proposed, to be called Feelings and Emotions: The Amsterdam Symposium", the objective of which is to provide a multidisciplinary overview of the state of the art of emotion research. Leading researchers from the various disciplines in which emotions form a major topic of investigation will each present an overview of the theoretical perspectives and research findings on emotion in his or her field. These disciplines will include psychology, neuroscience, biology, sociology, anthropology, philosophy, economics, psychiatry, and computer science. The number of presentations will be about 25.In addition, recent research results, notably those obtained by young researchers, will be presented and discussed during poster sessions. Training for young researchers consists of presentation of their projects and recent research results in poster sessions, discussion of the posters during those sessions, and participation in the general discussions after the keynote presentations.The audience will be recruited from among scientists from the various disciplines, young researchers, and interested others. The symposium is to be held in Amsterdam, Netherlands, during the Spring of 2001. The presentations will be published in book form.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00125-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Identifying the Location and Extent of Populations Trapped by Environmental Change in the Mekong Delta: An Agent-Based Modelling Approach'.

assistant: **Innovation**

The UK Foresight Migration and Global Environmental Change Project recently concluded that migration is likely to be increasingly influenced by environmental change in the future through the impact of climate change on economic, social and political drivers. However, the range and complexity of the interactions between these drivers means that it will rarely be possible to distinguish individuals for whom environmental factors are the sole driver. In parallel, within debates about climate change adaptation there has been an emerging trend to position migration as an adaptation strategy to environmental shocks and stresses. However, migration is expensive, requiring a number of assets/capitals. This can result in some populations who experience the impacts of environmental change seeing a reduction in the very capital required to enable a move. Environmental change is therefore equally likely to make migration less possible as more probable. In the decades ahead, millions of people are thus likely to be unable to move away from locations in which they are extremely vulnerable to environmental change. To the international community, this ‘trapped’ population is likely to represent just as important a policy concern as those who do migrate. In determining the extent and location of these populations the non-ubiquity of migration within a community needs to be accounted for in order to separate those people who want to migrate but are unable to do so from those who are unwilling to migrate and instead choose to cope with livelihood stresses in alternative ways. This distinction requires a contextually driven analysis of the decision to migrate or stay. Such a focus on the migration decision is suited to an agent-based modelling approach which takes into account an individua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rethinking emergency from a legal historical perspective: contexts, actors, practices, 1914-2020' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Rule of law and human rights are under pressure worldwide. The political and legal landscape is dramatically changing, with situations of crisis becoming a recurrent presence in the life of our polities. We thus witness a resurgence of emergency legislation and measures that states employ to tackle the nefarious effects caused by numerous disruptions: from financial instability to terrorist activity, pandemics, or military threat. Traditionally, emergency has been understood as a mechanism that has only temporary and limited effects on legal systems: once the crisis recedes, fundamental rights and constitutional process are restored. EMERGE argues that emergency has long-lasting effects subsisting the crisis. They affect our understanding of human rights, the rule of law principle and constitutional practices. EMERGE will advance a paradigmatic shift in the study of emergency by offering an original re-evaluation of the impact emergency has on the operation of the law. It will provide a much-needed legal historical explanation of how the historical experience of emergency has shaped constitutional and political cultures across Europe in the past century. Delivering a chronological examination and a timeline of the practice of emergency in relation to economic, social and political crises it will critically re-evaluate key moments in European constitutional history from 1914 to 2020. EMERGE will offer a comprehensive analysis of emergency by forging a unique multidisciplinary approach drawing on comparative legal history (contextual legal history), legal theory (law in action, law in context, narrative jurisprudence) and digital humanities (similarity, network and sentiment analysis). Rather than focusing exclusively on legal rules, it will study the agency of individual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Remote control of cellular signalling triggered by magnetic switching' (SIROCCO).

assistant: **Concept**

It is becoming increasingly clear that successful tissue engineering rests on capitalizing on more comprehensive understanding of mechanotransduction and its implication in skin homeostasis. In fact, the study of mechanotransduction is now a burgeoning research field, helping us to understand how cells respond to mechanical stimuli and convert them into biochemical signals, which in turn sheds light on the remote control of intracellular functions and the treatment of diseases. However, external activation of cellular signalling constitutes an important challenge due to the lack of non-invasive techniques that can be tuned in a spatiotemporal manner at a deep-tissue level.  SIROCCO aims to control different pathways related with cutaneous mechanotransduction by using magnetic switchers in order to enhance wound healing. Magnetic nanoparticles functionalized with oriented fragments of proteins will selectively recognize cell surface adhesion receptors (cadherins) present on the membrane of living cells. Once attached to the cellular surface, the MNPs will be activated using external magnetic fields in order to control key intracellular pathways. This ambitious goal will be validated using genetically modified 2D and 3D in vitro models, and the possibility to enhance wound healing and to modulate stem cell fate will be tested.  High precision remote control of cellular functions with temporal resolution is an extremely hot topic in tissue engineering. SIROCCO will go well beyond current state-of-the-art for non-invasive actuation of cellular functions in situ and will provide a powerful magnetomechanical transduction tool for mechanotransduction and tissue regeneration. The fundamental scientific advances proposed by SIROCCO are cross-disciplinary since these magnetic nan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Genetically enhanced, optically superior tissues (GHOSTS)'.

assistant: **Objectives**

Most biological tissues are optically opaque, largely precluding access by light microscopy. In stark contrast, some living tissues and organisms are highly transparent. Examples include many deep-sea fish, your retina, and cells that we exposed to directed evolution.Here we propose to uncover the genetic basis of tissue transparency, such that living cells and tissue cultures can be optically cleared by precision genetics. For this we will combine insights into origins of retina transparency, and a set of unique methods, to answer the question how genetically cells become more transparent during directed evolution.Specifically, we will use a three-fold approach to find transparency genes that do not compromise cellular integrity. For this we will use i) directed evolution towards transparency while co-selecting for cell fitness, ii) extensive phenotyping of transparent cells, both optically and functionally, and iii) use of transcriptomics to rule out stressed cells, and those that deviate too much from wildtype gene expression profiles.Knowing about physiological transparency genes will allow unprecedented insights into living tissues. If model tissues in the lab were just 1% as transparent as some glass-like fish found in the deep sea, optical microscopes could unleash their full potential, and enable high resolution views into developmental processes in their native environment. We see further transformative potential especially in the fields of organotypic tissue models, functional brain imaging, as well as pharmaceutical screens in 3D tissue cultures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'String Theory, QCD and Black Holes' (STRING-QCD-BH).

assistant: **Concept**

I intend to use string theory to understand gauge theories in four dimensions, both at strong and weak coupling. This includes describing strongly interacting gauge theories and their metastable vacua using their supergravity and string duals, as well as understanding gauge theories at intermediate coupling via integrability. It also includes using and developing new string-inspired twistor-space techniques to analyze QCD and N=1 amplitudes at one loop level. I also plan to thoroughly investigate the implications of string theory for the physics of black holes. In particular I want to construct and analyze black hole microstates -- smooth horizon-less solutions that are very similar to the black hole asymptotically, but differ from the black hole at the location of the horizon. Counting and understanding these microstates via the AdS-CFT correspondence will establish whether black holes should be thought of as ensembles of such microstate geometries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'LymphoDrain: The definitive solution for chronic lymphedema'.

assistant: **Innovation**

Lymphedema (LE) is a chronic disfunction of the lymphatic system causing fluid accumulation in the limbs, which affects more than 100 million patients worldwide. Its occurrence is closely related to cancer, being a very common side effect of cancer therapies, but can also arise from genetic disorders or due to injury, trauma, venous disorders, obesity, immobility,etc. Despite recent advances, at present there is no cure for LE which becomes a chronic disorder. The disease must be treated constantly by the patient, to avoid complications, with daily use of compression garments, physiotherapy and skin care. Thus, it creates a constant disability for the patient and, more importantly, it affects his/her ability to work and to live anormal life. In Europe, the financial impact of LE is valued at around €832 million in health and social welfare bills, with an additional €2.3 billion used to treat infections secondary to LE, as well as an additional €4.4 billion in loss of earnings as a result of productive incapacity of the patients. In addition, the prevalence of chronic LE is expected to grow as the lifeexpectancy increases and the global population ages. There is an urgent need for innovative approaches to restore continuous lymph flow drainage in affected tissues, producing a definitive solution for LE. Lymphatica´s subcutaneous implant, LymphoDrain, consists of a draining catheter and a micro-pump externally controlled by a wearable device, and replaces the function of lymphatic vessels. It is implanted via a minimally invasive procedure, and results in the resolution of the physiological impairments caused by LE reducing pain, the risk of potential complications and the need for additional treatments. Lymphatica´s goal is to convert LymphoDrain in the first definitive