RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effect of genetic variation in Mycobacterium tuberculosis on vaccine escape and the acquisition of drug resistance' (TBADAPT) targeting Sixth Framework.

assistant: **Abstract**

Tuberculosis (TB) remains a major public health threat, still emerging in some areas of the world. The major tools to control the TB epidemic are worldwide implementation of the directly observed therapy short course (DOTS) programme and BCG vaccination. However, these methods to control TB are not ideal. The efficacy of BCG vaccination is doubtful and significant problems with resistance against anti-TB drugs have emerged. These problems could be fuelled by the selection of more adapted variants of Mycobacterium tuberculosis.The proposed project aims to further investigate the hypothesis on the selection of M. tuberculosis genotypes by the measures used to control the epidemic; anti-TB treatment and BCG vaccination. These selection mechanisms will be investigated by studying the population structure of M. tuberculosis in various regions by using DNA fingerprint tools. Trends in the dynamics of the population structure (emerging genotypes) will be identified. The association of the various genotypes with drug resistance or possible vaccine escape will be studied. Furthermore, the influence of genetic variability among M. tuberculosis strains on the virulence and immune response induced by these strains and the protection of various vaccines against these strains will be studied in vivo.In addition, the effect of genetic variation in the M. tuberculosis genome on bacterial adaptability and response to stress will be studied. This will involve in vitro studies of the phenotypic effect of specific drug resistance and other mutations, with an emphasis on mutations in (putative) DNA repair genes. Insights into the adaptation of M. tuberculosis in response to control efforts should allow improved strategies for treatment and control and possibly reveal new targets for interve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Galileo Advanced Innovation Services'.

assistant: **Innovation**

The objective of the Galileo Advanced Innovation Services (GAINS) project is to implement effective Galileo Downstream Application Innovation Services and to coordinate them by implementing “innovation highway” as a seamless process on European scale. The project can build on validated prototypes of the modular services from within the existing, outstanding initiatives represented in the consortium: “European Satellite Navigation Competition” (ESNC) also known as “Galileo Masters” for the identification of promising business ideas, the open innovation environments provided by the European Network of Living Labs (ENoLL), the business acceleration services of entrepreneurship activity centres and the 90 company strong EuroTeleServ Association for scale-up and ENCADRE, the network of SatNav regions.The focused new contribution of the GAINS project is the implementation of “innovation highway” as a seamless process of coordinated Galileo Advanced Innovation Services, in the three main phases: idea recognition, product and services development, and new ventures creation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Habitability of Martian Environments: Exploring the Physiological and Environmental Limits of Life' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The low average temperature and low water activity of the Martian near-surface environment makes it challenging for living organisms to persist and propagate.  Nonetheless, recent mission results indicate that environmental conditions exceed locally and temporarily the lower thresholds for life to exist. Furthermore, specific soil minerals, or combinations thereof, appear to provide a suitable habitat for microbial life, especially if associated with low-temperature brines or hygroscopic salts. Thus, a quantitative understanding of the habitability potential of the Martian near-surface environment, past and present, is very much needed and the focus of this proposal. To achieve this objective, we will test different types of soils and some of Earth’s hardiest organisms, using them as models (‘Mars-analogues’), to see if they can survive and perhaps even grow under the various environmental stresses known to exist on Mars. A major tool of our laboratory investigations will be the experimentally proven state-of-the-art Mars Simulation Chamber at the German AeroSpace Center, to which various soils materials and microorganisms will be exposed. The planned experimental investigations and models will be concurrently updated by analyzed mission data, particularly from landers and rovers (e.g., Curiosity Rover), to adjust our work to the newest Martian geochemical and environmental data available. Results from our proposed work will timely provide critical scientific knowledge to interpret incoming data from ESA’s ExoMars mission, which is scheduled for launch in 2016/2018. As one important deliverable of our work we will also construct a Mars Soil Analyzer, an instrument which will be designed for a future mission to Mars with the objective to achieve Technology Readiness Leve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'On-board gasoline processor for fuel cell vehicle application ('PROFUEL')'.

assistant: **Innovation**

This project, as part of a cluster programme (Land Transport by Fuel Cell Technology), intend to develop a gasoline processing unit (composed of a dosing system, a reformer, a de-sulphurizer and a CO cleanup unit, with a proper control system based on CO and O2 sensors), capable of producing an H2-rich stream, pure enough for SPFC-feed purposes (low content of CO and sulphur compounds).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understand the Dimensions of Organised Crime and Terrorist Networks for Developing Effective and Efficient Security Solutions for First-line-practitioners and Professionals' (TAKEDOWN) targeting Horizon 2020.

assistant: **Abstract**

Organized Crime and Terrorist Networks (OC/TN) are a major challenge for the European Union and many different stakeholder groups are involved in creating awareness, preventing, identifying and intervene in case of risk or threat. But in order to develop better strategies and instruments, we still need a deeper understanding of these phenomena.TAKEDOWN therefore aims at generating such novel insights on OC/TN. In order to meet this challenge and to investigate this complex field of research a multidimensional modelling approach is used. The resulting, proprietary TAKEDOWN Model describes social, psychological, economic aspects as well as further dimensions, activities and response approaches. A comprehensive empirical research combined with European and international expert knowledge ensures a valid and intuitive model.The TAKEDOWN Open Information Hub targets first-line-practitioners and provides modular solutions and inductive materials. The public web platform helps individuals to navigate to the right third party reporting and help lines including an innovative crowd reporting application to report digital OC/TN cases.The TAKEDOWN OC/TN Professional Solution Platform consists of various modules for law enforcement and homeland security departments. Designed with a flexible Platform as a Service (PaaS) architecture it combines knowledge materials and digital security solutions. Via the TAKEDOWN Security Dashboard information streams of native and third party applications are combined in an identification and issue management cockpit. The TAKEDOWN Professional Advisor supports experts on the selection of relevant approaches and security solutions to tackle OC/TN.With this multi-level approach, TAKEDOWN will force a better understanding of OC/TN, develop modern approac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Crossroads of empires: archaeology, material culture and socio-political relationships in West Africa', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Knowledge of the last 1000 years in the West African Sahel comes largely from historical sources, which say that many regions were ruled by vast polities.The aim of my archaeological project is to seize how, in fact, lhe 'empires' of this region structured the landscape, and the movemenl of peoples, ideas, andthings, with a focus on the period AD 1200-1850. Is 'empire' really a useful term? I will confront historical evidence with archaeological data from one area atthe intersection of several polities: the dallols in Niger. This area is rich in remains, said to result from population movements and processes of religious andpolitical change, but these remains have been only briefly described so far. As this region is a key area of migrations and cross-influences, it is the ideal'laboratory' for exploring the materialisation of contacts and boundaries, through a mapping of material culture distributions.My project will approach these sites holistically, carrying out archaeological regional survey and prospection. Excavation will indicate chronology and culturalaffiliation. At lhe same time, I will take an interdisciplinary approach, using anthropological and oral-historical enquiries to obtain background information totest hypotheses generated by the archaeological data. Enquiries will assess how material culture can show group belonging and population shifts, andexamine the role of individuals called 'technical specialists'. This will help solve the current impasse in our understanding of vast empires which, though theyare historically known, remain poorly understood.My project will not just improve our knowledge of an almost-unknown part of the world, but thanks to its geographical location, interdisciplinary nature andstrong thematic framework, open up avenues of thin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Institut des hautes etudes scientifiques (IHES)' in the context of a Fifth Framework call.

assistant: **Objectives**

Description:The Institut des Hautes Studes Scientifiques is located in the wooded 12-acre domain of Bois-Marie, at Bures-sur-Yvette (20 km from Paris). Environment is very propitious to research with some famous neighbouring scientific institutions. Besides offices for the permanent scientific staff (10 persons) and the technical staff in the scientific building, there are 40 individual offices reserved for visitors, each furnished and equipped with the necessary computer equipment. There is also a computer room, a conference room sitting 90 persons and a meeting room. The library is presently located nearby in what used to be a music pavilion. IH+S is well known for the excellency of the research in mathematics and theoretical physics conducted there, for the freedom offered to its visitors and its scientific staff and for the fructuous exchanges of ideas the permanent staff and the visitors flowing through the Institute. The IH+S cultivates Excellency, Freedom and International Exchange at a level which makes it unique in Europe.Application:Applying to the IH+S is quite simple. Total access delivered under this contract: 99,83 man months. Total number of users: 62 persons.Project Manager:Jean-Pierre Bourguignon, 35 route de Chartes, Bures-sur-Yvette 91440, FranceTel: +33-1-60926667Fax: +33-1-60926669E-Mail: jpb@ihes.fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular exploitation of sobemoviruses' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Foreseen ResultsThe goals 1-3 will generate information that will be of general importance for the efficient expression of foreign proteins in transgenic plants. The goal 4 will generate virus expression vectors that will be generally useful in plant molecular plants. These vectors will allow high level expression of foreign proteins in plants without the need to resort to time consuming transformation technology. The sobemovirus vectors will also have practical importance that will be tested in this project by the expression of vaccine proteins in infected plants. This work reflects a novel approach to the production of oral vaccines for use ultimately in both animals and humans. The final goals 5 and 6 will lead to the production of virus resistant plants and are a potential solution to the disease problems posed by the two viruses used in this project. The recent development of transformation technology in monocotyledonous plants means that the transgenic resistance is now a feasible target of plant biotechnology. The analysis of natural resistance will have a longer term benefit in the production of plants resistant to sobemoviruses and other pathogens.The proposed work is a molecular analysis of cocksfoot mottle virus and rice yellow mottle virus. These are both members of the sobemovirus group and are pathogens of fodder crops and rice respectively. The programme has several related goals. These include:1. The characterization of structure and functions of various sobemovirus proteins;2. The understanding of translational strategies exploited by sobemoviruses;3. The identification of promoters for the subgenomic RNA synthesis and translational enhancers and the evaluation of their potential as tools for the construction of efficient plant expression vectors;4 Cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Improved Nano-Structure for Photocatalytic Efficient Cleaning of Surfaces' to be submitted under Horizon 2020.

assistant: **Abstract**

The photocatalytic self-cleaning products can be greatly beneficial by reducing the frequency of cleaning operations in exterior surfaces, reducing the maintenance and operational costs, and preserving the ecosystem, by avoiding the use of cleaning products with chemical agents. Still, available self-cleaning coatings are very limited, presenting short lifetimes and poor self-cleaning capacity. Joma developed the next generation of photocatalytic self-cleaning and anti-polluting technologies for the efficient treatment of concrete surfaces in urban areas, addressing not only the need for buildings and infrastructures’ maintenance reduction but also the major societal problem of urban air quality.Joma will deliver an improved titania-based technology, with a unique and proprietary nanostructure. The technology brings together a superior self-cleaning performance, anti-greening proven efficiency and anti-polluting potential, based on its higher photocatalytic activity, higher specificity for removal of the surrounding NO2, cost-effectiveness, high level of customization, possibility to combine with water protection and significant maintenance need reduction and consequent cost savings. The customized nanoparticle is the key component of Joma’s products representing an outstanding innovation against current stated-of-the-art in self-cleaning technologies.To bridge the remaining steps towards full scale commercialization of our nanotechnology, Joma has to widely demonstrate its economic and environmental assets over competing solutions and to consolidate our strategic partnering in the concrete manufacturing and maintenance industry value chain. Thus, Joma will leverage from the current SME instrument application as a stepping stone to prepare the company’s business strateg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sensitivity of human tumors to T cell attack' in the context of a Horizon 2020 call.

assistant: **Objectives**

The goal of this project is to describe the tumor cell-intrinsic mechanisms that determine whether ‘foreign’ human cancers are sensitive or resistant to the tumor-specific T cell response they induce. In this effort, I will focus on 3 linked questions: 1). While we know that T cell activity in human tumors can lead to cancer regression, we do not know whether such regression is mostly mediated by T cell secreted cytokines or granzyme mediated lysis. We will address this fundamental question by analysis of the sensitivity of human tumors to defined T cell effector mechanisms, and subsequent correlation to patient outcome upon immunotherapeutic intervention. 2). We will complement this analysis of baseline tumor sensitivity with a systematic analysis of acquired immunotherapy resistance in patients treated with T cell checkpoint blockade. Through comparative genomic and immunological analysis of pre- and post-therapy tumors we will determine the clinical importance of tumor cell-intrinsic mechanisms of acquired resistance, and will identify novel mechanisms of such resistance.3). In addition to these unbiased analyses of tumor resistance, we will focus on one resistance pathway of particular interest: Expression of PD-L1 has emerged as the key immune inhibitory pathway in human cancers, but our understanding of PD-L1 protein regulation is highly limited. We have recently identified PD-L1M1 as a molecular partner of PD-L1 that controls its cell surface abundance. A central goal of this application is to understand the function of the PD-L1 – PD-L1M1 complex, and whether PD-L1M1 can be used as a target for immunotherapeutic interventions.Collectively, this project exploits three approaches to reach one goal: fundamental insight into the mechanisms that control the sensitivi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A hybrid framework to characterize SLiM Mimicry by Leishmania (SMILE) parasites.' under Horizon 2020.

assistant: **Concept**

Pathogens invade and colonize their target host by modulating several key processes of host cells, resulting in modified physiology. Interference mechanisms are intensively studied in the case of viruses and bacteria, however, our knowledge about invasive eukaryotic pathogens is more limited.To understand how eukaryotic pathogens hijack host processes at the molecular level, Leishmania will be examined using computational methods and the results will be validated by experimental techniques. Leishmaniasis is a parasitic protozoan disease, responsible for non-resolving and chronic infection, affecting over 10 million people worldwide. Ongoing environmental changes are considered to be helping the disease to spread to new regions. Leishmania pathogenesis is poorly understood and to combat the infection and to control the disease, further insights into host-pathogen interaction are desperately needed.An integral part of the constant arms race between the host immune system and pathogens is the rapid evolution of pathogenic Short Linear Motifs (SLiMs), capable of modulating the host cell regulation. The limited sequence length of these protein-binding segments provides evolutionary advantages for the pathogen, as SLiMs can arise de novo and many can be packed into a single protein. Their properties make them hard to explore using biochemical methods alone, however, using bioinformatics approaches this process can be accelerated.SMILE aims to identify SLiMs mediating Leishmaniasis. My hierarchical strategy starts from protein level identification to detailed structural characterisation of host-pathogen interactions, as an ultimate goal. The description of SLiMs already suggests novel therapeutic strategies to counteract mutation-based diseases.  The outcome of the project has