RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Four-dimensional self-assembly from peptides and DNA' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Structural organisation in living systems is both dynamic (varies with time), and emergent (more than the sum of its parts). Different blends of these aspects can be said to contribute to all the uniquely impressive processes of cellular biology. In contrast, synthetic self-assembled chemical systems rarely express each of these properties, being largely based on single self-assembly systems (e.g. DNA hybridisation or metal coordination), and static (i.e. observed at its thermodynamic minimum). This Fellowship will combine the Fellow's skills in chemoenzymatic peptide synthesis with those of the Supervisor in combining complementary self-assembly systems to obtain emergent superstructures. These studies will result in the first instances of dynamic and emergent self-assembly in synthetic chemical systems.To achieve this aim, we will perform chemoenzymatic polymerisation of peptides from the end of DNA backbones. Both units are capable of their own self-assembly - DNA through hybridisation, and peptides via secondary structures. In any 'static' snapshot of the system, the indirect interplay of DNA and peptide assembly will lead to highly unusual nanostructures. However, this work will go beyond, to measure the type and extent of self-assembly during the enzymatic polymerisation process using cutting edge techniques such as liquid-cell electron microscopy. The resultant systems will recapitulate the properties of living matter in these respects.In the course of these studies, the Fellow's professional skills will be honed through mentorship, the practice of taking a leading role in research, and through training courses offered by the Host Institution. At the end of the Fellowship, he will be ideally placed to assume an independent academic position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Increasing disaster Resilience by establishing a sustainable process to support Standardisation of technologies and services' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Standardisation is a powerful tool to achieve better interoperability. However, it needs to overcome a lack of interest and modest participation from stakeholders. Also, promising research results are not always used as the basis for new standards.The overall goal of ResiStand is to find new ways to improve the crisis management and disaster resilience capabilities of the European Union and individual Member States through standardisation.ResiStand contributes to an improved disaster resilience by identifying and analysing the drivers, constraints and expectations of three main stakeholder communities: Standardisation Organisations, End-Users and Suppliers, consisting of researchers, industry and SMEs.Based on this information, gaps in standardisation are identified and a prioritised roadmap for new initiatives will be created. The roadmap will be complemented by a critical evaluation of standards as a tool to improve disaster resilience.ResiStand aims at implementing a pre-standardisation process that supports the development of standards. The feasibility of the process will be tested by developing a new work item. The aim is that stakeholders will continuously utilize this “ResiStand Process” in the future, and that the project delivers a better understanding of the potential of standards for contributing to an improved disaster resilience.ResiStand will support the management of increasing threats to society such as armed conflicts, terrorism, pandemics and natural disasters, which have increasingly cross-border, even global consequences due to the on-going globalisation.Protection of citizens through anticipation, preparedness, response and adaptation to crisis situations – i.e. maintaining disaster resilience – will be more efficient. Collaboration between national
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HIF-1α in Cancer-Associated Fibroblasts: Unveiling implications for the tumor microenvironment and therapeutic strategies', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Despite significant advancements in understanding CRC pathogenesis, the clinical prognosis of CRC patients is still poor due to metastasis dissemination. Cancer progression is often associated with the presence of cancer-associated fibroblasts (CAFs) in the tumor microenvironment that regulate processes such as extracellular matrix (ECM) deposition and repression of the immune response. The establishment of a hypoxic environment and activation of its main effector, the hypoxia-inducible factor-1α (HIF-1α), are common features of advanced cancers.  HIF-1α is a transcription factor, which regulates several genes that are exploited by tumor cells to escape from a nutrient-deprived environment and to survive as well as resist to treatment. However, the role of HIF-1α in CAFs has not be addressed so far in CRC. This research seeks to elucidate the effects of hypoxia on different aspects of CAFs' function , using in vitro functional assays and innovative co-culture models with patient-derived CAFs and matching tumor organoids. Furthermore, the study aims to unveil the role of HIF-1α expression in CAFs during tumor initiation and progression using a colitis-associated carcinogenesis model and pinpoint the origin of HIF-1α+ CAFs employing a lineage tracing model. Finally, in silico analysis of scRNAseq data will allow to detect the subset of CAFs that are responsive to hypoxia in different stages of carcinogenesis and in metastatic dissemination. Overall, this project will study the unappreciated role of HIF-1α in CAFs in the context of CRC with the ultimate goal to pave the way to new therapeutic strategies.


**Keywords:** Colorectal cancer,  Cancer associated fibroblasts,  Tumor microenvironmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ANALYSIS OF SPECIATION MECHANISMS IN RNA VIRUSES' (RNAVIRSPE) under Seventh Framework.

assistant: **Objectives**

Parasites have high socio-economic impact due to their negative effect on humans, animals and plants welfare. Parasite evolution may lead to emergence of new infectious diseases, and compromise existing disease control strategies. Viruses are one of the most important groups of parasites causing a large fraction of emerging diseases. Adaptation to new environments may lead to population diversification, including “speciation” events resulting in the appearance of new viruses. Ecological and genetic factors are important in determining virus evolution. Environmental modifications impose selection pressures, thus changes in host population density or distribution will result in the appearance of new viral strains or species. Mutation and recombination are the main mechanisms for generating genetic variability in RNA viruses: their high mutation rates allow them to evolve rapidly adapting to new environments. Exchange of gene modules between related viral strains (modular evolution) may also result in new variants with higher fitness. We will analyze the role of these evolutionary mechanisms in the processes of virus speciation using bioinformatic tools applied to genomic sequence datasets. Analyses will focus on the families Picornaviridae, Coronaviridae and Potyviridae as models for RNA virus evolution. The three families have been widely studied, as they are important human, domestic animals and wildlife, and crop pathogens, with high sociological and agronomic relevance. Sequence data, together with information on host range and geographical distribution, are available for a large number of species and strains of these families. However, despite this data availability, to date there has been no extensive analysis of the patterns and processes of RNA virus speciation. U
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cultural heritage Advanced Research Infrastructures: Synergy for a Multidisciplinary Approach to Conservation/Restoration' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

CHARISMA is an Integrated Infrastructure Initiative that brings together 22 leading European institutions developing research on artwork materials and their deterioration finalised to the conservation of cultural heritage. The consortium has the objective to optimise the use of infrastructures through a coordinated program of transnational access, joint research and networking activities.  Transnational access offers applicants opportunities to exploit the services of three different and complementary groups of facilities, embedded in a multidisciplinary environment involving material science and artwork conservation/restoration. They are:i)a group of six archives containing a huge amount of analytical data, hosted by the most prestigious European museums and institutions developing safeguard and conservation of cultural heritage;ii)a set of advanced portable instrumentation for in-situ non-invasive measurements in the same site where the artworks are located or exhibited;iii)two platforms, one in France and one in Hungary, where large scale facilities are coupled to a set of medium scale instrumentations, open to users for the most advanced studies on artwork materials and their alterations.Research is devoted:i)to improve access to databases exploiting digitalisation of data and their harmonisation;ii)to design and set-up innovative instrumentations, for in-situ 2D and 3D examinations of artworks, and new cleaning techniques;iii)to develop new methodologies for the study of organic materials and their distribution  in micro-samples or directly at the surface of the object.Through networking, the way infrastructures are working is improved, harmonising methodologies and best practices in analysis and conservation, pursuing the establishment of a multidisciplinary syner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SELECTION VERSUS DRIFT IN THE RISE OF DELETERIOUS MUTATIONS: THE CASE OF  FAMILIAL MEDITERRANEAN FEVER' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Familial Mediterranean Fever (FMF) is the most frequent monogenic autoinflammatory disease worldwide. It is caused by mutations in the gene pyrin which are surprisingly frequent (up to 20%) in individuals of East Mediterranean ancestry. The evolutionary forces behind such a high local mutation load are unknown but it has been suggested as an example of balancing selection with a selection pressure from past infections. Hemoglobin disease variants conferring malaria protection are the (rare) textbook examples of such but are atypical with recent and unusually high selective pressure. By taking advantage of the human population history of Armenia, the excellent preservation conditions of archaeological remains in the region, and remarkably high frequency of FMF disease in the Armenian population, the FeverTime project aims to develop the most comprehensive real time account on the role of evolutionary forces in the local mutation burden. FeverTime will leverage ancient DNA time series data from Armenia within a sophisticated population genomic analytical framework to yield key results regarding the evolution and spread of the disease. The findings will have broad implications for genetic epidemiology, reflecting EU policy priorities


**Keywords:** ancient DNA, Familial Mediterranean Fever, Armenia, selection, genetic drift
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending Coherence for Hardware-Driven Optimizations in Multicore Architectures' to be submitted under Horizon 2020.

assistant: **Abstract**

Multicore processors are present nowadays in most digital devices, from smartphones to high-performanceservers. The increasing computational power of these processors is essential for enabling many importantemerging application domains such as big-data, media, medical, or scientific modeling. A fundamentaltechnique to improve performance is speculation, a technique that consists in executing work before it isknown if it is actually needed. In hardware, speculation significantly increases energy consumption byperforming unnecessary operations, while speculation in software (e.g., compilers) is not the default thuspreventing performance optimizations. Since performance in current multicores is limited by their powerbudget, it is imperative to make multicores as energy-efficient as possible to increase performance evenfurther.In a multicore architecture, the cache coherence protocol is an essential component since its unique butchallenging role is to offer a simple and unified view of the memory hierarchy. This project envisions thatextending the role of the coherence protocol to simplify other system components will be the key toovercome the performance and energy limitations of current multicores. In particular, ECHO proposes toadd simple but effective extensions to the cache coherence protocol in order to (i) reduce and eveneliminate misspeculations at the processing cores and synchronization mechanisms and to (ii) enablespeculative optimizations at compile time. The goal of this innovative approach is to improve theperformance and energy efficiency of future multicore architectures. To accomplish the objectivesproposed in this project, I will build on my 14 years expertise in cache coherence, documented in over 40publications of high impact.


**Keywords:** Cache coher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Waste4Bio: Advancing Food Waste Utilization Through Multiplatform Biorefinery' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Food waste (FW) is a significant global issue, with around one-third of all food produced wasted annually. FW biorefineries constitutes a green route to valorise the enormous untapped potential of FW via its bioconversion into marketable products and fuels in a circular bioeconomy scheme. However, to date, FW biorefineries have not reached the maturity level needed for full-scale and widespread application. To meet the European Green Deal and Sustainable Development Goals, Waste4Bio project aims at engineering and validating an innovative, cost-competitive FW biorefinery for the cascade production of biohydrogen (bioH2) and biodegradable biopolymers (polyhydroxyalkanoates; PHAs). To this end, Waste4Bio will go beyond of the state-of-the-art of dark fermentation to design advanced mass transfer hydrogen-producing fermenters able to support a high density of biocatalyst and a superior bioH2 production performance. Waste4Bio will also upgrade the acidogenic gas mixture evolved by using well-engineered outdoor algal-bacterial photobioreactors to produce near-pure bioH2 and treat the carbon dioxide into algal biomass, contributing to a net-zero carbon balance for FW valorisation. In addition, the DF broth rich in short-chain carboxylic compounds will be further valorised for highly efficient PHA production with purple phototrophic bacteria (PPB). This action also aims at bringing deeper understanding of the microbiome, and its associated potential functionality and ecological interactions, involved in every fermentative bioH2 production, photosynthetic bioH2 upgrading, and PPB-based PHA production stage. Waste4Bio with transferable skills and a cross-sectoral nature will apply a cross-disciplinary approach involving bioprocess and chemical engineering, environmental biotechn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The European comparative gramineae mapping programme' (EGRAM) targeting Fourth Framework.

assistant: **Abstract**

The EGRAM project, coordinated by AMICA, brings together 20 partners from universities, government institutions and industry representing nine European countries (including sub-contractors) and Australia t develop methodologies to isolate and study useful genes from cereals and grasses; combining information generated on these species through understanding their comparative genome structure; and using rice as th central species for comparative genetic analysis and rice DNA libraries as entry points for gene isolation. Partners are grouped into four Sections with activities as follows: I Resources (4 partners) - The centre of the EGRAM project, providing a framework of mapped rice populations with free access to contiged large-insert rice libraries (YACs and BACs) to allow genome comparisons and gene cloning activities later in the EGRAM project and beyond. The partners of this Section will also map key probes from other EGRAM partners who want to locate genes of interest on th rice genome. The consensus cereal and grass maps will be extended to include meadow fescue, which i still poorly characterized at the molecular level. In addition,genes for 50 phenological, morphologic physiological and biochemical mutations in barley will be integrated onto the cereal molecular maps using collections of well-defined mutations, targeting each of the seven homoeologous Triticeae chromosome, Mutated seeds of at least nine major cereals and grasses will also be generated for future use. II Diseases (5 partners) - Studies on resistance (R) genes will identify, tag and clone R genes for rusts i wheat and rye grass, and several diseases of barley to test positional cloning methods and R gene sequence homologies in rice. Major R genes will be mapped as well as QTLs for durable and quanti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Commercialisation and scale up of a Vaginal Microbiome Screening service with a menstrual tampon collection device and a digital layer to provide diagnosis, disease risk evaluation and aftercare.'.

assistant: **Innovation**

VMS is a home-based gynaecological test kit, using a menstrual tampon for sample collection. VMS will improve the accuracy and convenience with which STI, vaginal infections and HPV screening is undertaken. Daye has patented the proprietary protocol for DNA extraction from a tampon for PCR analysis, testing for 16 different factors at a time. VMS can be used to detect vaginal dysbiosis, HPV and STIs, like chlamydia, gonorrhea and trichomoniasis. Vaginal microbiome screening with VMS will unlock invaluable insights into our customers’ vaginal health. There’s a direct correlation between vaginal microbiome health and the likelihood of contracting an STI, developing a gynecological cancer, experiencing fertility and pregnancy challenges, as well as susceptibility to recurrent vaginal and urethral infections. Post screen, VMS will offer comprehensive aftercare, including prescriptions, doctor consultations, booking in-person visits, and vaginal microbiome enhancement plan with probiotics


**Keywords:** eHealth,Health record,Disease prevention,Business model innovation,Interoperable secured communications (Security sys,Biotechnology,Microbiology,Infectious diseases,Health-related biotechnology,Personalised treatment,Obstetrics and gynaecology,Longitudinal data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Realising Education through Virtual Environments and Augmented Locations' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

State-of-the art Virtual Reality (VR) technologies designed for gaming offer new opportunities for social and economic benefits in their application to education. This project will pioneer the use of mainstream PlayStation VR technologies for innovative educational applications which engage world-wide audiences in the Europe’s rich historical and scientific heritage. Supported by the R&D team at Sony Interactive Entertainment Europe (SIEE), it will actively inform and map the processes and technologies required for SMEs to successfully bring new gamified VR applications to Sony’s online PlayStation Store. The resulting technology and tools will provide an infrastructure for creating educational VR experiences and generate new business opportunities outside of traditional gaming activities on the PlayStation platform. In the process it will create inclusive narrative-driven VR experiences which improve the social and physical accessibility of cultural heritage and contribute to the digital preservation of historical sites.