RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Single-Molecule Technology for Resolving Chaperone Action in Neurodegenerative Diseases' (MicroSPARK), addressing dissemination and exploitation.

assistant: **Impact**

A range of debilitating neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, arise from the formation of amyloidogenic protein aggregates. Molecular chaperones can counteract aggregate formation, but their molecular action mechanisms remain poorly understood. This is chiefly due to the fundamental challenge of resolving heterogeneous and dynamic aggregating protein species in the presence of chaperones. In order to address this challenge and to advance our knowledge of chaperone action, I propose establishing µSPARK, a novel technology that will allow, for the first time, the unravelling of the detailed microscopic mechanisms by which chaperones target and disassemble amyloidogenic protein species in heterogeneous mixtures at the single-molecule level. These new insights will become possible through the first-time combination and seamless integration of two advanced technologies: (i) Miniaturized fluidic sorting devices and (ii) single-molecule fluorescence spectroscopy combined with three-colour coincidence detection. This will enable high-throughput single-particle interrogation of individual chaperone–aggregate complexes providing fundamentally new means for understanding key aspects of chaperone function. To demonstrate the new possibilities, µSPARK will be exploited to unravel the action mechanisms of heat-shock proteins in curtailing amyloid-β peptide and α-synuclein aggregation. This will provide new insights into proteostatic regulatory mechanisms in Alzheimer’s and Parkinson’s disease. The µSPARK technology will then be exploited to dissect—with high throughput and single-particle resolution—the molecular action mechanisms of small-molecule modulators that promote the inhibitory function of chaperones on protein aggregation. This will al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Algorithm developments for unstructured viscous flow solver' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Title algorithm developments for an unstructured viscous flow solver The objective of this research proposal is to devise efficient numerical algorithms for the computation of viscous flows around complex aerospace geometries. The two key areas of investigation are; the use of hybrid meshes which are a mix of tetrahedra, prisms and hexahedra, retaining some 'structure' in the grid within the boundary laser where the cells are most highly stretched, and the exploitation of this 'structure' by a locally line-implicit method used as a 'smoother' within a multigrid procedure. This will be designed to relieve the 'numerical stiffness' associated with using highly stretched meshes. One key aim of this work is to devise a viscous multigrid algorithm that maintains the high degree of efficiency already achieved for inviscid methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Creation of an autonomous in board miniaturized water waste purification plant for riverboats with adaptation to european norms' to be submitted under Fourth Framework.

assistant: **Abstract**

As no automatic filtration system currently exists, many chemical and biological studies will have to be carried out on a large number of experiences and tests dedicated to the boat industry before launching the project and to check the existing devices. A research is necessary to determine the characteristics of the biological conditioning of the equipments required to give a perfect result, that means to reject a clear water in the rivers, protecting the waterlife and the hygiene conditions. The research project consists of engineering an autonomous miniaturised sewerage disposal for boats (like river boats) circulating on waterways or residentials (like house boats), allowing the purification of human waste and domestic sewage in order to manage water waste in accordance with the notion of clean boating, the protection of environment and the regulations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spiking Control Systems: an algorithmic theory for control design of physical event-based systems' in the context of a Horizon Europe call.

assistant: **Objectives**

Machines compute with bits and clocks, animals compute with spikes and rhythms. The promise of neuromorphic engineering is that we could transform digital technology by imitating the spiking nature of animal computation, combining analog adaptation and digital reliability. Thirty years after Carver Mead’s initial proposal, event cameras have become a technology and neuromorphic computing has become an intense focus both in academia and in industry. Yet, we still lack a proper theory of event-based computation and event-based design. And the very nature of computing with rhythms instead of clocks is still poorly understood.We propose that the spike is a consequence of analog computing with mixed (that is, positive and negative) feedback. We will develop a control theory of spiking systems by leveraging the control theory of negative feedback systems to a theory of mixed-feedback systems. The mathematical concept of monotonicity provides a modern and unifying foundation for control theory, convex optimisation, and circuit design. Our spiking control theory is grounded in mixed-monotonicity. It is algorithmic because it leverages the methodology of convex optimisation, and it is physical because it leverages the methodology of circuit theory.  A central objective of the proposed research is a novel event-based internal model principle of significance both for control theory and neuroscience. We will investigate the unique features of event-based online adaptation, and suggest the complementary roles of inhibition and excitation in novel spiking control architectures whose learning and adaptation capabilities can be dynamically modulated.Ultimately, this proposal aims at novel design principles for physical devices that could surpass the  learning and adaptation capabilitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Experimental and theoretical study of non-linear propagation of intense femtosecond laser pulses' (1994-1998).

assistant: **Innovation**

The subject of the thesis work concerns the study of non-linear propagation of ultra-short (50 fs) very intense (l0 power 12 W/cm2) optical pulses through transparent non-linear media such as air, glass and other materials. In a first step, the phase profile of the optical pulse will be determined experimentally at various locations using a newly developed method ( 1 ) . The experimental results will be confronted to numerical simulations using the 3-d non-linear Schroedinger equation, to be developed. After the numerical code is fully validated, I will explore new situations where quasi-stable 'light-bullets' are predicted (self-guiding effects). Experiments testing the numerical analysis will be performed with a Terrawatt Ti:Sapphire scillator-amplifier system available at the L.O.A.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Zooplankton Generated Mixing in Stratified Lakes'.

assistant: **Innovation**

The aims of this work are to directly measure turbulence from vertical migrations of zooplankton, quantify how much mixing the migrations cause, and determine the importance of this mechanism in lakes. Answering these questions will help us better understand the physical drivers of water quality in lakes, environments upon which society depends for many key ecosystem services.Summer time stratification in lakes suppresses vertical mixing of dissolved substances such as oxygen, nutrients, or pollutants. This can lead to adverse water quality affects such as anoxic bottom waters that result in fish kills, trapping of nutrient-laden waters in the photic zone creating ideal conditions for nuisance algal blooms, and reduced dilution of wastewaters and nonpoint source pollution.Processes that generate turbulence below the water surface increase the mixing of the stratified waters. Recent work in the ocean has suggested that daily vertical migrations of zooplankton might be a significant source of mixing comparable with winds and tides. Zooplankton, which are significant elements of lake ecosystems as well, swim between deeper darker regions of the water column, where they stay during daylight to avoid predation, and the phytoplankton-rich surface layer, where they go to feed during the nighttime.Because the background mixing in lakes is less than in the ocean and migrations happen twice daily, vertical migrations of zooplankton may be a significant source of turbulence and mixing in the lake environment. The work proposed here would be the first in situ measurements of zooplankton-generated turbulence in lakes. In addition to tackling recent issues of debate in the science community, this work will enhance understanding of mixing in lakes, a key issue in managing our water re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enabling Incompatible Tandem Reactions through Spatial Separation of Reaction Layers', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Todays technology for the biocatalytic production of base chemicals is fossil-fuel based. Moving away from non-renewable and carbon-based energy feedstocks towards renewable hydrogen is a key challenge for current chemical processes. However, biocatalysis has yet to see H2 implemented as a energy source, simply because such H2-consuming reactions are sensitive to O2, whereas many enzymatic reactions driving product formation require O2 as a cosubstrate. H2-driven biocatalysis is not realized today on a large scale because of this need for both O2-sensitive and O2-dependent reactions to operate in tandem. The goal of this Marie Skodowska-Curie Postdoctoral Fellowship project is to deliver the theoretical framework and experimental validation for novel biohybrid catalytic microdisks capable of carrying out seemingly incompatible tandem reactions by controlling the spatial separation of reaction layers (ReLay). Driven by both theory and simulation, the optimal conditions will be found to create both anaerobic and aerobic domains allowing O2-sensitive and O2-dependent reactions to take place within a single particle. This will be accomplished by, first, building a reaction-diffusion model and simulation toolbox to establish the theoretical framework of spatially separated reaction layers in these catalytic micodisks. Second, the parameter space will be explored using the model and simulations to find the best performing components and conditions. Finally, these predictions will be validated with an experimental case-study, comparing the expected output from the model with the actual reaction rates and concentrations gradients measured experimentally for an O2-dependent oxyfunctionalization driven by H2 within the catalytic microdisks. These actions will create a universal p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cognitive Empowerment Resulting in Environmental Sustainability  Improvement (CERES+). Human-Machine interaction in Industrial Vehicles through an innovative Augmented Reality System.' (CERES) targeting Horizon 2020.

assistant: **Abstract**

Cognitive Empowerment Resulting in Environmental Sustainability  Improvement (CERES+).Vehicles used in industrial applications, such as in agriculture, forestry, construction (or earth moving), and mining, are increasingly empowered by digital information (i.e., sensors) in their production. This evolution has many benefits but there might also be negative side effects. Operation of industrial vehicles can be related with cognitive challenges and high mentalload. For example, already today the working situation of a forestry harvester operator has been compared to that of a fighter pilot.Optea has developed the first high Field Of View (FOV) Head Up Display’s (HUD’s) that supports augmented reality, for forestry and agriculture.Blending system information with the real world, which enhance situational awareness of operators on the field without unduly exert their vision and cognitive power or forcing them in unnatural positions.Optea system is the only HUD 'plug and play' system already tested in relevant field capable of solving several specific applications needed in the targeted off-highway vehicle markets Optea HUD will in fact 1) allow for a higher vehicle productivity, 2) lower threshold for new drivers (including young workforce and women), 3) increase safety, 4) offer ergonomic improvements, 5) lower fuel consumption derived from smarter vehicle operation. According to a study by Global Information Inc. , the global off-highway vehicle market is expected to register a CAGR of 7.79% between 2018 and 2023 and will reach a market size of over 35 B€ by 2020. Optea is gearing up to capture the leading position as provider of HUD systems in Europe by 2023. The CERES+ SME Phase 1 project will study the feasibility for commercialization and commodification of the Optea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Isolation of rare circulating tumor cells' to be submitted under Horizon 2020.

assistant: **Abstract**

In 2013 I was awarded an ERC consolidator grant to pursue a novel cancer targeting concept using a recombinant malaria protein. As an ERC grantee I verified the malaria protein (rVAR2) binds to this distinct cancer expressed molecule (CSA) in hundreds of cancer cell lines and thousands of tissue biopsies. Our research demonstrate a pivotal role of CSA in cancer cell migration and thus in the formation of metastasis. Circulating tumor cells (CTCs) are cancer cells escaping the primary tumor with the capacity to settle and form a metastasis in distant organs. Isolation of CTC is thus a very attractive non-invasive measure of the stage of a given cancer and provides the opportunity to do direct phenotypic analyses. However CTCs are in most cases very rare (10 cells pr 1ml blood) and does not uniformly distinguish themselves from normal blood cells. Our preliminary data show that rVAR2 very effectively can be used to isolate CTCs from diverse types of cancer with unprecedented specificity and sensitivity. Such a tool could have wide impact for cancer patients because it could sharpen diagnosis, increase prognostic ability, monitor drug efficacy and facilitate molecular characterization of individual cancers with implications for personalized medicine and basic cancer research.  The aim of the ERC PoC project is to A) prepare for establishment of a separate company with a strategic product plan and B) further develop and validate the methodology enabling diagnosis, prognosis and guide treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of novel quantum dot based materials for compact laser devices for potential telecommunication and biophotonic applications' under Seventh Framework.

assistant: **Concept**

The goal of the project is the development of portable, low-cost, reliable and highly-efficient ultrashort pulse (down to 100 fs) laser sources based on quantum dot (QD) material working in the spectral range 1.0-1.6 microns. This new generation of QD based mode-locked lasers has to become an alternative to the conventionally used ultrafast solid-state lasers, which are very expensive, cumbersome and complex to operate. The proposed research has a very high practical significance because it creates the possibility for evolution in different science and medical areas, in particular, advanced telecommunication, terahertz generation, optical sampling, biophotonics, non-invasive medical diagnosis and therapeutics.By placing a primary emphasis on novel materials, devices and system designs, this project will encompass a range of challenging and cutting-edge research directions that exploit QD-based semiconductor structures.The work in the frame of this project will mainly be focused on epitaxial growth of QD-based laser structures. It will be devoted to the optimisation of the epitaxial growth procedure, testing optical, structural and transport measurements and working on the design of epitaxial structure and design of the final devices.This research is in the area of interest of the host organisation and is interdependent with other projects running at the department. I will closely collaborate with other researchers in the fields of laser device design, laser characterisation and discuss results at every stage of the project.Moving to DTU, I bring all of my knowledge gained during my PhD and postdoctoral research work in Russia and France, which will lead to new scientific achievements at DTU. My connections to international scientists will increase the collaboration of D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Parallel use of yeast and mammalians for dissecting secretory traffic' (2002-2006).

assistant: **Innovation**

Protein transport is fundamental for practically all-cellular processes, and defects in trafficking are associated with a variety of diseases. The Golgi apparatus is the main centre that regulates sorting to different cellular domains. While many genes and proteins have been described that regulate these processes, the carriers and mechanisms involved in Golgi to plasma membrane transport still require much clarification. Yeast has been an invaluable tool in defining genes that modulate the secretory pathway, and many of the genes/proteins/mechanisms described in yeast are conserved in higher eukaryotes.The most significant progress in the knowledge of Golgi function has come from yeast genetics and from molecular and morphofunctional studies in mammals. However, the osmosis between yeast and mammalian research fields has been very limited so far. The rationale of the project is to combine the power of yeast genetics with the accuracy of morphofunctional analysis that can be reached only in mammalian cells. This systematic cross-species approach is in principle extremely powerful since it would compensate the defects and magnify the advantages intrinsic in the yeast and mammalian systems.Yeast offers the unique opportunity to rapidly manipulate protein expression and to screen for multiple functional and physical protein interactions, but does not easily allow a detailed morphofunctional analysis. The latter is more accessible in mammals where one major limitation is instead the inability to block rapidly (i .e. within the time scale of the event being examined) the function of a protein. This host driven action is designed to gain competence in the area of yeast genetics and biology to complement the highly successful research that has been applied to this important ar