RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CONSTRUCTION OF BESPOKE EVALUATION POWER MODULES~(MATPLAN)'.

assistant: **Innovation**

The objective of this proposal is to develop double side cooled packaging solutions for semiconductors eliminating the use of inherently unreliable aluminium wire bonds and replacing with seamless contacting techniques to either side of the active semiconductor thereby providing a very reliable low thermal resistance,low inductance contact . The solutions developed using innovative additive laser machining and lost wax techniques will be applicable to not only todays active components but tomorrows.Theconstructional methods developed to package the activedevices will be inherently low cost compared to those associated with todays double side cooled structures. The double side cooled structures emanating out of this project will be extremely manufacturable and will offer the ultimate in longterm reliability required by the aerospace industry and will facilitate the use of higher temeprature devices operating at higher current densities and frequencies i.e SiC. In the event of system over currents the devices designed within the project are intended to fail short circuit . The ability for Europe to have an indigenous semiconductor supplier able to supply advanced components packaged in a unique thermal efficient, compact and reliable manner will give the EUs systems suppliers a significant competitive edge in aerospace and other advanced applications. A 10KW silicon carbide inverter based on specification supplied by the SGOs is envisaged.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photochromic coatings with long time durability and fast switching based on organic-anorganic hybrids and organic photochromes for flat glass and plastic substrates' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

High performance and long term stable photochromic components are required for the wide spread use of smart windows and eyeglass application. At present they are fabricated from organic photochromes applied to plastics by very special, expensive techniques or from mineral glasses with a very special composition and microstructure, that are in general not suitable for large area applications. The objective of this project is to develop a generally applicable photochromic coating based on new organic photochromes in tailored organic inorganic nanocomposites with excellent scratch resistance for plastics and mineral glass substrates and to demonstrate its technical and economical feasibility by several photochromic plastic eyeglass lenses, sunglasses, visors and ski goggles with lifetimes > 2 years, switching times < 30 s and acceptable scratch resistance and by a full size laminated mineral glass car roof and a special architectural double glazing, with lifetimes > 5 years and switching times < 60 s. The baseline of the project is the experience of GLC in development and production of organic photochromes, stabilizers and optical polymers and an already existing nano technology for organic inorganic hybrid materials with tailored materials properties and technologies at INM. The claimed technical innovation is the development for the first time of photochromic coatings that are applicable to both plastics and glass substrates with a high potential for a breakthrough of photochromic smart materials for large areas and high added value applications in a wide field. The general approach is the use of organic inorganic nano composite host materials, available at INM, with tailored microstructure providing high mobility of the photochromic dye together with high scratch resist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular Imaging to Guide Repair and Advance Therapy: Targeting the inflammation-fibrosis axis in ischemic heart disease and remote organs', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Myocardial infarction triggers a complex interplay between inflammation and fibroblast activation, which contributes to success or failure of adequate repair. Targeted therapeutic approaches to modulate these processes have not yet been implemented clinically. The dynamic and multicellular nature of the inflammatory and fibrotic repair process in the heart is thought to be variable among individuals. Additionally, cardiac injury and treatment affect distant organs through systems-based interaction. In MIGRATe, I will explore non-invasive molecular imaging approaches to interrogate inflammatory cell populations and fibroblast activation in the heart and networking organs, for precise guidance of targeted therapeutic interventions. Imaging will delineate optimal timing and/or targeting of treatment to support endogenous healing and prevent heart failure progression. MIGRATe will also bring together imaging methods and molecular biology to decode the tissue microenvironment and identify novel biomarkers amenable to imaging and treatment. A combination of in vivo molecular imaging, single cell sorting, and transcriptome data from regions with elevated and/or suppressed imaging signal will be exploited to identify disproportionate cell subpopulations that contribute to the prognostic signal and may be targeted by therapy. Whole body imaging will simultaneously reveal the impact of cardiac cell directed therapy on the heart, alongside distant organ function, providing new insights into inter-organ communication and supporting a wholistic approach towards repair. Experimental work in mouse models will be complemented by a proof-of-concept clinical study, establishing a translational environment. Taken together, MIGRATe is designed to optimize new imaging-guided, molecular-targ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The role of non-growing season processes in the methane and nitrous oxide budgets in pristine northern ecosystems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The response of the terrestrial biosphere to climate change is still largely unknown and represents a key uncertainty in climate change predictions. High latitude regions, including Arctic and boreal ecosystems, constitute a key component of the earth system due to significant soil carbon stocks. High latitude regions are net sources of greenhouse gases, such as methane (CH4) and nitrous oxide (N2O), but there is significant disagreement among flux estimates with further uncertainty due to a rapidly changing environment. Climate change effects are particularly strong during the non-growing season, altering the timing of spring snowmelt, fall freeze-up, and increasing winter temperatures. The changes have significant implications for biogeochemical cycles and ecosystem function across high latitude regions.Despite growing evidence of the importance of non-growing season greenhouse gas emissions, few measurements have been made in pristine Arctic and boreal ecosystems. Non-growing season CH4 emissions can account for 10-100% of annual CH4 flux, while next to nothing is known about emissions of N2O during this period. Process-based models miss non-growing season emissions of CH4, underestimating them by 67% and annual emissions by 25%. I will use complementary observations (WP1), modelling (WP2), and experiments (WP3) to quantify the annual magnitude of CH4 and N2O flux, identify controls on non-growing season flux, and assess why existing models of CH4 flux fail outside of the growing season. Are environmental conditions so different that existing model parameters fail, or is non-growing season biogeochemistry fundamentally different? The overall impact is to shift the paradigm from “nothing happens outside of the growing season” to “capturing non-growing season processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unravelling maintenance mechanisms of immune tolerance after termination of venom immunotherapy by means of clonal mast cell diseases' (MITafterVIT) targeting Horizon 2020.

assistant: **Abstract**

Anaphylaxis is the most severe form of a systemic hypersensitivity reaction, which can be fatal within minutes after exposure to a trigger such as wasp venom. VIT has been the only treatment available to prevent subsequent anaphylactic wasp-sting reactions even years after treatment termination.The goal of this project is to understand molecular mechanisms of maintained immune tolerance (MIT) after completing venom immunotherapy (VIT). We aim to find biomarkers for MIT that could be specifically triggered to increase efficiency of VIT. In contrast to wasp venom anaphylactic patients of the general population, wasp venom anaphylactic patients with a clonal mast cell disease (CMD) do not maintain immune tolerance after VIT termination. These patients carry a clonal D816V point mutation in the tyrosine kinase receptor KIT. We hypothesize that the MIT in wasp venom anaphylactic CMD patients is dysregulated due to the carriage of KIT D816V mutation in immune cells. We will, therefore, compare blood plasma proteins and blood cells of venom-induced anaphylaxis patients with a CMD to patients without a CMD. This project addresses our hypothesis with three specific objectives: Firstly, we will identify plasma proteins (in work package 1; WP1) and, secondly, blood cell types (WP2) that are crucial for MIT. Thirdly, we will study the role of the identified candidates from WP1 and WP2 in maintaining immune tolerance (WP3) and investigate whether or not the detected dysregulations are due to KIT D816V (WP3).We estimate that our results will, therefore, be directly relevant for 0.3% of the European population who experience anaphylaxis and bares potential to be also beneficial for patients suffering from other allergic diseases, which account for a significant part of the population
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Functional characterization of phytoplasma candidate virulence proteins that target plant cell nuclei'.

assistant: **Concept**

Phytoplasmas are insect-transmitted intracellular bacterial pathogens that infect plants in domesticated (crops) and natural habitats worldwide. Typically, they induce shoot proliferation and differentiation of floral parts into leafy structures, suggesting interference with basic cellular and developmental pathways.The applicant has led a consortium that sequenced the 724 kbp genome of aster yellows phytoplasma strain witches¿ broom (AY-WB), and is involved in two further phytoplasma sequencing programmes. Analysis of the AY-WB sequence identified 58 candidate virulence proteins, of which 8 have nuclear localization signals (NLSs). Two of these proteins (A11 and A30) target nuclei in plant cells.The objective of this proposal is to functionally characterize those candidate virulence proteins that target plant nuclei, with the hypothesis that they could change gene expression profiles through interactions with transcription factors and regulatory sequences. This work takes advantage of the broad host range of AY-WB that includes Nicotiana benthamiana, tomato, and Arabidopsis.The specific aims of the proposal are:- to determine the localization of all AY-WB NLS-containing proteins in plants;- to conduct expression-profiling experiments on plants exposed to A11 and A30;- to assess whether A11 and A30 bind regulatory sequences and transcription factors and how this may affect host susceptibility.Relative to other work on bacterial virulence in plants, the work is distinctive in focusing on virulence factors that target nuclei and on intracellular bacterial pathogens. Finally, this project will transfer research experience and knowledge obtained during a seven-year career in the USA to the John Innes Centre, Norwich, UK.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Optimization of gold ores leaching processes in order to reduce environmental hazards'.

assistant: **Innovation**

Objectives and content The gold ores considered as difficult to be processed include mainly complex ores in which matrix minerals are sulfides and sulfoarsenides, sometimes associated with copper minerals. The conventional process is the cyanidation, which involves for environment and workers some hazards (emissions of gaseous cyanhydric acid and liquid wastes). The objectives of the project are:  to carry out cyanidation in a closed horizontal stirred grinding mill (HSGM) fed with pumps. The overflow hazards, which could appear with a conventional ball mill, should be prevented; moreover, the HSGM behaving like a quasi-perfect mixer, leaching times and volumes of liquids should be significantly reduced;  to accelerate cyanidation using catalysts;  to complex gold with reagents other than cyanide (thiourea and chlorine) of which the effectiveness in laboratory tests is ascertained but which, in a conventional technology at industrial scale, are hindered by the passivation of the gold particles surfaces; that passivation may be prevented in a stirred mill owing to a permanent attrition. The planned investigation consists of:  comparing the technology proposed at laboratory and pilot scales with the conventional technology in which grinding in a ball mill and leaching in agitated tanks is operated successively;  proposing and testing new process flowsheets;  evaluating the process economy. For that purpose, 3 typical gold materials will be used: an arsenopyrite flotation concentrate; a gravimetric mixed concentrate containing free gold and copper; mining wastes and residues from a roasting and cyanidation processing operations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Consumer-safe and thermally-stable bioplastic formulation with controlled biodegradation properties for agricultural and horticultural accessories' in the context of a Seventh Framework call.

assistant: **Objectives**

The consumption of plastic materials in agriculture and horticulture in EU has dramatically increased in the last decades posing serious problems of environmental and economic concerns. Agriculture and Horticulture sector generates about 1.2 Mt of plastic waste per year in the Europe, where almost 30% (336 Kt) are coming from accessories such as nets and clips for plant support and plastics pots and trays for greenhouses and bed-seeds. The recycling of these products is very expensive and time-consuming due to the high labour cost for the collection and the impossibility to be automatized. In addition, these products must be low-cost and stable during storage and use. So far, existing bio-degradable plastics have serious product costs and performance issues that are unacceptable to agricultural-horticultural professionals. In addition, there are no clear methods to test the migration levels of biodegradable agricultural plastics in contact with agri-food during their growth.By joining the efforts of three National Associations from Agricultural, Bioplastic and Food Quality sectors, DEGRICOL Consortium will develop cost-competitive, 100% natural-based bioplastic formulation based on a thermally stable and crystalline PLA matrix for the manufacturing of Agriculture and Horticulture accessories. Such formulation will contain natural fillers (such as lignin or chitosan) isolated from animal- and agro-residues to further reduce costs and, and bio-surfactants (humic acid-like) isolated from compost of urban food or agro-residues to improve and control the biodegradation process according to their use. In addition, These accessories, pots and clips (manufactured through injection moulding process) and tutors and nets (trough fibre-extrusion process) will have the requirements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Robots for Exploration, Digital Preservation and Visualization of Archeological Sites'.

assistant: **Objectives**

Mapping and digitizing archeological sites is an important task to preserve cultural heritage and to make it accessible to the public.  Current systems for digitizing sites typically build upon static 3D laser scanning technology that is brought into archeological sites by humans. This is acceptable in general, but prevents the digitization of sites that are inaccessible by humans. In the field of robotics, however, there has recently been a tremendous progress in the development of autonomous robots that can access hazardous areas. ROVINA aims at extending this line of research with respect to reliability, accuracy and autonomy to enable the novel application scenario of autonomously mapping of areas of high archeological value that are hardly accessible.<br/>ROVINA will develop methods for building accurate, textured 3D models of large sites including annotations and semantic information. To construct the detailed model, it will combine innovative techniques to interpret vision and depth data.  ROVINA will furthermore develop advanced techniques for the safe navigation in the cultural heritage site.  To actively control the robot, ROVINA will provide interfaces with different levels of robot autonomy. Already during the exploration mission, we will visualize relevant environmental aspects to the end-users so that they can appropriately interact and provide direct feedback.  Our system will allow experts, virtual tourists and potentially construction companies to carefully inspect otherwise inaccessible historic sites.  The International Council on Monuments and Sites will exploit the 3D models and technology.  The ROVINA consortium is targeted at developing novel methods that will, besides the indicated goal, also open new perspectives for applications where autonomy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Translational Control of Neuronal Fate and Identity' under Horizon Europe.

assistant: **Concept**

The cerebral cortex is a central structure of the mammalian brain, characterized by a remarkable diversity of neuronal types. Understanding the origin of the extraordinary neuronal diversity is fundamental to understand how cortical architecture and functions emerge during development and remains a critical challenge in cellular and molecular neurobiology.While the efforts have been focused on transcriptional control, evidence for regulation at the translational level is emerging. I hypothesize that translational control, albeit overlooked, acts in a combinatorial fashion with transcriptional induction to regulate gene expression programs during cortical patterning. I have demonstrated an intimate functional link between cortical development and pools of mature transfer RNA (tRNAs), the major determinant of translation. I, therefore, propose to address how translational control, through the modulation of the availability of mature translationally competent tRNAs, fine-tunes gene expression programs during lineage progression, thereby regulating neuronal diversity. Studying this yet unexplored question should unravel a hitherto unrecognized level of neuronal fate identity determination in the cerebral cortex. We will combine ribosome profiling, mRNA and tRNA deep sequencing, screening of genetic perturbation and gene manipulation in vivo in the mouse embryonic cortex to i) uncover the specific translational programs that influence neuronal lineages progression; ii) determine how tRNA repertoires (both at the transcriptional and post-transcriptional levels) are shaped to meet the specific translational needs of different cell types during corticogenesis and iii) validate the functional importance of fluctuation in mature tRNA content during cortical development. This proj