RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of parvalbumin interneurons in cognition and behavior', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cognition is a collective term for complex but sophisticated mental processes such as attention, learning, social interaction, language production, decision making and other executive functions. For normal brain function, these higher-order functions need to be aptly regulated and controlled, and the physiology and cellular substrates for cognitive functions are under intense investigation. The loss of cognitive control is intricately related to pathological states such as schizophrenia, depression, attention deficit hyperactive disorder and addiction.Synchronized neural activity can be observed when the brain performs several important functions, including cognitive processes. As an example, gamma activity (30-80 Hz) predicts the allocation of attention and theta activity (4-12 Hz) is tightly linked to memory processes. A large body of work indicates that the integrity of local and global neural synchrony is mediated by interneuron networks and actuated by the balance of different neuromodulators.However, much knowledge is still needed on the functional role interneurons play in cognitive processes, i.e. how the interneurons contribute to local and global network processes subserving cognition, and ultimately play a role in behavior. In addition, we need to understand how neuro-modulators, such as dopamine, regulate interneuron function.The proposed project aims to functionally determine the specific role the parvalbumin interneurons and the neuromodulator dopamine in aspects of cognition, and in behavior. In addition, we ask the question if cognition can be enhanced.We are employing a true multidisciplinary approach where brain activity is recorded in conjunctions with optogenetic manipulations of parvalbumin interneurons in animals performing cognitive tasks. In one
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital Disruptive Technologies to Co-create, Co-produce and Co-manage Open Public Services along with Citizens' (CO3), addressing dissemination and exploitation.

assistant: **Impact**

CO3 aims at assessing the benefits and risks of disruptive technologies, namely: blockchain, augmented reality, geolocated social network, liquid democracy tools and gamification, in the co-creation, co-production and co-management of public services with citizens as PAs partners. Augmented Reality becomes a single shared layer on the urban paysage and part of citizen’s public life, AR enables manipulation of financial objects built on blockchains, information sharing on a map, online deliberations and so  constitutes an infrastructure for service  co-production by citizens. CO3 pilots the technologies’ ecosystem of in three sites. It evaluates the outcomes of the new interaction model between PA and citizens under a set of metrics in three dimensions : 1) social and cultural: citizen engagement, change in relationship with public servants; 2) economic: value of services produced, effects on workplaces, consumptions and economic sustainability; 3) legal: legal implications for PA including privacy and data protection. CO3 will devise a business plan ensuring long term sustainability for the PAs on the basis of the metrics applied on the pilots’ data. CO3 is a participative and interdisciplinary project, the Consortium involves: University of Torino (IT)(Computer Science, Economics, Sociology and Law), ISMB private research center (IT), Fundación Universitaria Balmes (ES), Institut de Recherche et d’Innovation of Centre Pompidou (FR), and OpenLab Athens (EL), with its Laboratory of the Digital Commons. It also involves three highly innovative SMEs: Brainbot, leaders in the Ethereum Blockchain development(DE), FlexiGuided (DE), the company that created LiquidFeedback, Geomotion (ES) working on augmented reality and location-based technologies. Municipality of Torino (IT)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sustainable Indium Phosphide (InP) platform and ecosystem upscaling, enabling future mass market (sub-)THz applications'.

assistant: **Innovation**

Electronic devices evolved significantly, fuelling the digital transformation towards a connected society. To growing need for performance, speed and efficiency pushes wireless applications to operate at sub-THz frequencies and beyond. Today’s technologies, however, come short to efficiently and effectively utilize these frequencies, even taking into account technological evolutions. A disruptive yet commercially viable technology is urgently needed. Indium Phosphide (InP) has outstanding and unique capabilities to surpass other technologies in terms of high-frequency performance. Today, InP is only adopted in niche markets because of its costly and scarce substrates. Move2THz will transform the InP platform and build a fully integrated European value chain providing commercially attractive, ecology-friendly, mass-market technologies suitable for sub-THz frequency operation and beyond, enabling emerging applications like mobile/data connectivity, imaging and sensing.To achieve this, Move2THz will radically innovate the manufacturing process by establishing a breakthrough InP-on-silicon (InPoSi) global standard. This facilitates to upscale the wafer size & volume compatible with CMOS manufacturing capacities, while minimizing the use of rare InP resources and ecological footprint. Further up the value chain, the European InP platform will be developed, matured and adopted through substrates, manufacturing, design and foundry services, including integration, packaging and education.Through Move2THz, the technical excellence provided by our consortium and the technologies developed in this project will significantly strengthen the competitive and sovereign position of Europe. It will secure its supply of semiconductors in a sustainable way for the next generations of wirel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a durable resistance strategy based on genetic and ecological approaches for the bean-angular leaf spot (als) disease pathosystem in central america and brazil', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The angular leaf spot (ALS) disease of common bean (Hazels Vulgarism L.) caused by Phaeoisariopsis griseola (Sacc.) Ferr. (lsariopsis griseola Sacc.) is found world-wide and is considered to be one of the most important biotic constraints leading to yield losses which can reach 80% in pure stand. In the context of subsistence agriculture prevailing in Latin America, genetic resistance is the most suitable control method, but its main drawback is resistance breakdown caused by pathogen adaptation. The general objective of the programme is to develop an integrated strategy for durable ALS resistance in agro systems prevailing in Central America (with Costa-Rica as experimental base) and Brazil. The project aims at developing a rational approach of cultural practices (mixtures of cultivars and associated crops prevailing in the countries involved in the research).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Secure contracts signed by telephone' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The SecurePhone project aims at developing a new mobile communication system infrastructure which will ensure in a friendly way the mutual identification of mobile phone speakers enabling them to deal legally binding e-contracts by a mobile phone call. The existing communication infrastructure, lacking strong users identification, cannot be used for legally binding transactions.The solution proposed by this project is to realise an innovative prototypal 3G/B3G enabled PDA enhanced with a biometric recogniser" in order to permit to users to mutually recognise each other and securely authenticate. The SecurePhone will then allow users to securely exchange and modify audio, image and/or text files, and finally to e-sign them with legal value, all during a phone call. In particular the SecurePhone will permit to e-sign voice statements on the fly. Thanks to the SecurePhone the device legitimate user will be authenticated by comparing several of his/her biometrical features measured in non- intrusive way with registration data previously stored on the device SIM card.A choice for non- intrusive, psychologically neutral biometric techniques has been made, so as to avoid the problems of rejection and discomfort that affect the social use of other methods. Biometrically recognised users will access the device's built-in peculiar and innovative e-signing facilities. The system will enable users, without needing to enterany extra numeric PIN, to electronically sign and send data, concurrently with voice, during a normal phone call, using PKI infrastructure resident on their device SIM, thus getting rid of an extra smart card reader. In particular, users will be given the opportunity to choose between transmitting encoded audio file or text files, produced through automatic speech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New roles for the cytoskeleton in cell-autonomous immunity to mycobacteria' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Cell-autonomous immunity is the ability of a host cell to eliminate an invasive infectious agent. Recent work has shown that components of the cytoskeleton have a major role in cell-autonomous immunity and control of bacterial infection. The Mostowy group has shown that some intracellular bacteria, including Shigella flexneri and Mycobacterium marinum, can escape from phagosomes and invade the host cell cytosol where they interact with cytoskeleton components to form actin tails or be entrapped in septin cage-like structures. However, our knowledge of these interactions derives from a limited number of in vitro studies, and has not been fully characterized in vivo during a disease-causing infection. M. marinum, a species closely related to the human pathogen M. tuberculosis, can be applied as a paradigm to understand the cell biology of mycobacterial infection. Zebrafish is naturally susceptible to M. marinum and, as I have shown during my PhD, can be used as an important animal model to gain in-depth information about the innate immune response to bacterial infection. Using state-of-the-art genome editing tools and high resolution microscopy techniques, I will study M. marinum interactions with the cytoskeleton, and investigate the role of these interactions in cell-autonomous immunity. Using M. marinum, my specific objectives are: 1) to identify and characterize host and pathogen determinants affecting autophagy-cytoskeleton interactions, and 2) to investigate the discovered molecules and mechanisms in vivo using the zebrafish model. A more comprehensive understanding of M. marinum-cytoskeleton interactions will have important consequences for enhancing host defense and fighting antimicrobial resistance. This should provide vital clues towards new strategies aimed at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantitative understanding of a living system and its engineering as a cellular organelle' in the context of a Seventh Framework call.

assistant: **Objectives**

The idea of harnessing living organisms for treating human diseases is not new but, so far, the majority of the living vectors used in human therapy are viruses which have the disadvantage of the limited number of genes and networks that can contain. Bacteria allow the cloning of complex networks and the possibility of making a large plethora of compounds, naturally or through careful redesign. One of the main limitations for the use of bacteria to treat human diseases is their complexity, the existence of a cell wall that difficult the communication with the target cells, the lack of control over its growth and the immune response that will elicit on its target. Ideally one would like to have a very small bacterium (of a mitochondria size), with no cell wall, which could be grown in Vitro, be genetically manipulated, for which we will have enough data to allow a complete understanding of its behaviour and which could live as a human cell parasite. Such a microorganism could in principle be used as a living vector in which genes of interests, or networks producing organic molecules of medical relevance, could be introduced under in Vitro conditions and then inoculated on extracted human cells or in the organism, and then become a new organelle in the host. Then, it could produce and secrete into the host proteins which will be needed to correct a genetic disease, or drugs needed by the patient. To do that, we need to understand in excruciating detail the Biology of the target bacterium and how to interface with the host cell cycle (Systems biology aspect). Then we need to have engineering tools (network design, protein design, simulations) to modify the target bacterium to behave like an organelle once inside the cell (Synthetic biology aspect). M.pneumoniae could be su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantitative MRI of the brain using magnetic resonance fingerprinting' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Alterations in the intrinsic physical tissue parameters measured with magnetic resonance imaging (MRI), such as of longitudinal (T1) and transverse (T2) relaxation times, have been implicated in major neurological conditions. Although these differences have been noted as useful signs in image contrasts, parameter quantification has not been exploited as a marker for disease stage or for monitoring treatment efficacy. Previous attempts to perform quantitative MRI protocols have suffered from sensitivity to system imperfections as well as infeasible, long acquisition times. Recently, a new approach called MR fingerprinting (MRF) has been developed for the estimation of multiple parameters at once, featuring a new dedicated acquisition strategy. The method has shown great promise as data can be acquired in clinically acceptable time, is relatively insensitive to system imperfections and has high accuracy. To date, only two dimensional datasets using a single acquisition strategy (balanced steady state free precession bSSFP) have been explored. Further, this was using a rather slow reconstruction algorithm at 1.5T. In addition, the technique has not been yet applied outside healthy volunteer groups.In this project we aim to develop a 3D MRF acquisition for imaging the whole brain with optimized acquisition trajectories. We will compare different acquisition strategies, including strategies sensitive to magnetic susceptibility in the brain, previously unexplored. The sequence parameters will be optimized using a dedicated novel genetic algorithm. An accelerated reconstruction software using a novel algorithm will be developed using graphics processing units. Initial data will be acquired with new protocols at 7T and at 1.5T. Statistical parametric maps will be used to invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Role of GST gene variation in susceptibility to mercury (Hg)-induced neurodevelopmental disorders (NDD) in zebrafish'.

assistant: **Innovation**

Environmental factors, including the heavy metal mercury, are recognized as having a dominant influence on the aetiology and prevalence of neurodevelopmental behavioural disorders. This proposal will develop a new model for assessing the role of gene:environment interactions, specifically genetic predisposition for toxicity, in risk for disease, and identify early markers predictive of toxicity and later phenotypes. This will directly relate to the EC work program for Health, demographic change and wellbeing, with respect to both 'Personalized medicine' for non-communicable diseases and 'Early development' addressing mental health from childhood to older ages. The project uses the zebrafish model to investigate the relationship between glutathione-S-transferase (GST)-related genetic background, developmental exposure to mercury, and risk for neurodevelopmental disorders. This will be achieved by exposure of wild-type and CRISPR-generated Gst mutant embryos to mercury, and testing whether genetic predisposition leads to increased risk for toxin-induced behavioural phenotypes. We will test for altered biochemical, transcriptomic and epigenomic modifications that may serve as potential early markers for insult. The results obtained in this proposal will have significant impact on the ability to conduct individual and population specific toxicity risk assessment, and may lead to novel measures for early detection of increased risk and alleviation of potential adverse outcomes. The high-quality original research presented in the proposal will not only enable the Experienced Researcher to reach a position of professional maturity in her career, but will also allow her to develop a spectrum of new and interdisciplinary skills, integrating her previous training and knowledge in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating Pathways of Steatohepatitis' (EPoS) under Horizon 2020.

assistant: **Objectives**

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibrosis/cirrhosis; and hepatocellular carcinoma in the absence of high alcohol consumption. Up to 30% of the EU population have NAFLD, which will be the main aetiology underlying liver transplants by 2020. However, NAFLD is characterized by substantial inter-patient variability in severity and rate of progression. What determines this is unknown. A large population is at risk, but only some experience morbidity. NAFLD severity is currently best assessed by liver biopsy, an invasive, costly and risky procedure - factors that hinder treatment. There is a need to understand the biological and environmental factors that drive inter-patient variability and to develop robust and more acceptable methods for diagnosis, risk stratification and therapy so that effective medical care may be targeted to those that will benefit most. The overall EPoS concept is that improved understanding of pathogenic processes and drivers of disease progression will best be achieved when multiple ‘omics’ approaches are applied to a single cohort of patients to build a multi-dimensional record of how systems are perturbed across the entire spectrum of disease. NAFLD sits at the intersection of key biological processes: carbohydrate/lipid homeostasis, immune/inflammatory activation, wound healing/fibrosis and cancer biology. Once completed, EPoS promises to deliver a substantial and definitive atlas of pathoph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Towards the european society - challenges for education and training policies arising from the european integration and enlargement' (1998-2002).

assistant: **Innovation**

The proposed Thematic Network intends to focus on the impact of the social, political and economic integration of the European societies, including the integration of the accession countries on the policy domain of E&T in Europe. It will reflect on the consequences of the Internationalisation and Europeanisation of E&T for European policies and trans-national research in this policy domain. The proposed network will try to gain more knowledge about the European dimension in E&T, both in terms of political strategies and trans-national research needs.