RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Disposable well-plate inserts and perfusion chambers for easy-to-use and generic microchannel creation in 3D tissue culture'.

assistant: **Concept**

Functional 3D tissue models could replace animal experiments and significantly reduce the cost of over 100 million € that pharmaceutical companies spend on failed drug development every year. The main bottleneck in the in vitro creation of 3D tissues is the need for perfusable vascularization in tissues bigger than 1 mm. So far, no generally applicable product exists for that purpose. This hampers advances in drug development as well as in research.Design2Flow will develop products, which overcome this limitation and enable the individualized on-demand creation of perfusable and therefore larger and more complex tissues. This will fundamentally reform research in life sciences by offering easy-to-use, customizable, perfusable 3D cell culture products of interest to the pharmaceutical industry and research labs. To achieve this goal melt electrowriting will be utilized to fabricate sacrificial scaffolds, which resemble the native microvasculature. The fabricated scaffolds will be combined with insert clips as easy-to-use designs for multiwell plates, which will allow a passive perfusion of the construct to keep the tissue alive without the need for a special pump – a beginner friendly way to start advanced 3D cell culture with basic laboratory equipment, without the need for expensive devices or experienced personal. For customers working with perfusion pumps, the proposed solution will be adapted to perfusion chambers for an active and controllable perfusion of the tissue by flow reactors, mimicking the in vivo blood flow even more accurately. This will provide an advanced and customizable way to create tissues as accurate as possible for physiological cultivation in bioreactors.


**Keywords:** Tissue Engineering,  Microchannel creation,  Perfusion chamber,  Well plate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Coordination of Vehicle and Road Safety Initiatives' (COVER), addressing dissemination and exploitation.

assistant: **Impact**

In 2005, around 41,600 people were killed and more than 1.7 million injured in European road accidents. Although the number of road fatalities has declined by more than 17% since 2001, greater efforts will have to be made if the European Commission’s target of halving the number of deaths on the roads by 2010 is to be met. To realise the targets for road safety in the future, stakeholders indicate the necessity of integrating research capacities currently existing or emerging as far as possible. For this purpose the general objectives of COVER are to develop a harmonised and consistent direction of research and to accelerate the implementation of research findings of four complementary EU and US initiatives dealing with road and, in particular, vehicle safety. To maximise the benefits gained from the individual initiatives synergies between the projects will be fully exploited by coordinating the exchange and usage of results, joining dissemination actions towards relevant stakeholders, and exchanging of best practices and policies with respect to relevant aspects like test methods and deployment strategies. For the objective of dissemination – both towards relevant high-level stakeholders and the general public – a coordinated approach will be an important factor in providing a clear message and obtaining the necessary visibility. This visibility of research results will be the precondition of the effective deployment in vehicle safety products and enhanced test and evaluation methods Subsequently, COVER brings together coordinators of three FP7 and, relevant for harmonisation with the US, one USDOT initiative. Together with partners from the participating projects the coordinators identified joined research activities needed to enable the introduction of new vehicle s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid Adaptive Robust Optimization Strategy for EWIS High Dimensional systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Complexity in modern aircrafts is increasing significantly. They incorporate more electric systems since other subsystems that used to be pneumatic or hydraulic are being replaced by electric systems. As a consequence, the wire harnesses that are used to connect those systems to each other must also convey more signals. The industrial-grade wiring harness acts as the central nervous system to many device and vehicle electronics designs, particularly in the aeronautic and aerospace segments. As applications become increasingly complex, innovation in wiring harness design and manufacturing techniques becomes more critical. This project will research and implement new methods for more efficiently driving design data toward fully automated design optimization so to better analyse costs, to help ensure the successful design and manufacture of new wiring harness products.For this purpose, the goal of this project is to link the unique state-of-the-art surrogate modelling technologies available at Noesis to develop new surrogate-based optimization techniques and software solutions suitable to solve wire harness large scale optimization problems. The resulting hybrid, adaptive and robust optimization strategy will allow optimization of high dimensional systems (HAROS-HD, Hybrid Adaptive Robust Optimization Strategy for High Dimensional systems) by means of smart adoption of model order reduction techniques coupled with surrogate models.The main advantages of this approach include:-Design engineers do not need to spend time and effort trying to understand their design space before choosing a suitable optimization algorithm. HAROS-HD will learn about the design space and employ the appropriate algorithms as it proceedstoward finding an optimized solution.-Design engineers are not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for anticancer therapy. However, ADC have e.g. limitations with respect to tumor penetration, high manufacturing costs, and require challenging conjugation chemistry. Peptide-drug conjugates can have a high drug loading, easily penetrate tissue, and can be easily prepared in a homogenous form with straightforward and well-defined conjugation chemistry. The ETN MAGICBULLET will focus on chemistry-driven approaches toward conjugates between peptides (delivery vectors) that recognize tumors and anticancer drugs (payloads or warheads) in order to selectively fight cancer, a topic with a high demand of research activities. The ETN will develop and validate an array of new peptide-drug conjugates combining either known tumor-specific peptides or newly discovered tumor-homing peptides with potent cytotoxic drugs. The tumor-selective peptides are designed for cellular uptake mediated either by endocytosis or by cell-penetrating peptides. The consortium of the ETN MAGICBULLET covers tumor biology, biochemistry, pharmacology, synthetic chemistry, medicinal chemistry, spectroscopy, conformational analysis, and computational chemistry. The training program focuses on multidisciplinary research to explore and validate molecular targets for innovative treatment or investigations on the molecular mechanisms in organ-specific metastatic growth processes. It aims at scientific multilingualism and rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Papuans on the move. The linguistic prehistory of the West Papuan languages.' under Horizon 2020.

assistant: **Concept**

This project combines urgent documentation of endangered languages in Indonesia with rigorous investiga-tion of a linguistic puzzle that has important implications for our understanding of both Melanesian and Southeast Asian prehistory. Some two dozen Papuan languages, scattered over a 1000km on and around the Bird's Head of West Papua, show signs of sharing a common origin. The OUTOFPAPUA project uses cut-ting-edge methods in historical linguistics to test the hypothesis that these languages belong to a single West Papuan language family, and to investigate the possibility that their distribution reflects a migration of Papuan people, in relatively late prehistoric times, from the New Guinea mainland outward and westward into the Indonesian archipelago. The project will also address the question of what drove this putative expansion, in particular the possibility that it had to do with indigenous agricultural innovations. Thus, it contributes both to the difficult enterprise of uncovering genealogical relationships among the diverse languages of New Guinea, and to a growing body of research that questions the orthodox linguistic understanding of eastern Indonesia's prehistory in terms of an eastward expansion of Austronesian speakers at the expense of less dynamic Papuan populations. At a methodological level, the project furthers the development of techniques for establishing remote historical linguistic relationships in the absence of written records of relevant languages. The project will make innovative comparisons using a suite of techniques, including the application of new computational methods, the construction of a lexical database of unparalleled richness in Papuan linguistics, and by giving a prominent role to semantic shifts, paleolinguistics, and morpholog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neuroendocrine interactions betwenn energy balance and reproduction in fish' (1998-2002).

assistant: **Innovation**

Neuropeptide Y (NPY) is involved in the regulation of a variety of physiological events including pituitary hormone secretion, energy balance, and feeding behavior. The aim of the research project is to study the functional relationship between energy balance, hypothalamic orexigenic NPY and pituitary luteinizing hormone (M) secretion in fish, using the sea bass (Dicentrarchus labrax L.), as the experimental model. Some good evidences have been already found finding that in juvenile sea bass, under negative energetic balance imposed by chronic fasting, LH secretion "in vivo" is dose dependently enhanced in response to NPY. These data will be pursued by investigating the mRNA expression and peptides levels of NPY, GnRH (brain gonadotropin-releasing hormone) and LH as well as effects of NPY on LH - GnRS axis under negative or positive energetic balance. This investigation will be screened throughout different periods of starvation, and reproductive stage in male and female sea bass in order to understand possible sexual dimorphism and influences of the sexual cycle in these processes. Finally, the presence of leptin, the product of obesity (ob) gene in mammals, and the functional studies on the effect of leptin on energetic homeostasis, food intake and neuroendocrine function will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An integrative approach to unravel the ocean's biological carbon pump' (CarbOcean), addressing dissemination and exploitation.

assistant: **Impact**

The ocean’s biological carbon pump plays a crucial role in storing atmospheric carbon dioxide in the deep ocean, thereby isolating carbon from the atmosphere for decades to centuries. Yet, its capacity to do so is under-constrained and its mechanisms poorly understood. CarbOcean will develop a mechanistic and quantitative understanding of the biological carbon pump using a novel integrative approach that accounts for its two component pumps: (1) the organic carbon pump, which concerns the photosynthetic production of particulate organic carbon, POC, and (2) the carbonate pump, which concerns the production of particulate inorganic carbon, PIC. These pumps have opposite effects on the ocean-atmosphere exchange of carbon dioxide. I will nurture the development of a breakthrough autonomous robotic ocean profiler, uniquely capable of simultaneous observations of PIC and POC fluxes and physicochemical parameters from the well-lit surface ocean through the underlying twilight zone (roughly 100 – 1000 m depth) over a continuum of spatiotemporal scales. The robotic profilers will be deployed in a wide variety of oceanic environments and the collected data will allow investigation of links between the export and sequestration of POC and PIC, examination of pump interconnection, and detection of pump drivers. New parameterizations of carbon flux processes will be developed and implemented in a biogeochemical model. Lastly, the carbon flux data collected will be up-scaled to the global ocean using artificial intelligence approaches, thereby exploiting synergies among various observational platforms, including remote sensing. CarbOcean is a strongly interdisciplinary project, connecting fundamental and applied optical oceanography with biogeochemistry, carbonate chemistry, advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a novel Industrial Fish Drying and Maturing Process to secure Seafood Safety, Traceability, and Quality' (SAFETRACKFOOD) targeting Seventh Framework.

assistant: **Abstract**

The European Union (EU-27) is a net importer of seafood with an overall negative trading balance of 3.9 million tonnes worth €13.7 billion, while importing 6.2 million tonnes worth €17.3 billion and exporting 2.3 million tonnes worth €3.5 billion. The total world trade of seafood has reached in 2004 a record export value of almost €54 billion, representing a 23% growth relative to 2000. Analysis of trends in the seafood industry shows new business opportunities in new innovative value added products in terms of convenience and health. Ready-to cook or ready-to-eat products, coated products and other value-added items constitue a fast-growing industry. The European stockfish industry - producing matured and dried gutted whole fish (round fish) from lean fish, mainly cod, but also ling, tusk, haddock and saithe - is facing several problems to follow the new market trend and to be competitive. Today, the stockfish production is still performed outdoors, where the fish is hanging unprotected on wooden rack using the sun and wind to dry. The stockfish product quality varies greatly with varying weather conditions. Today, up to 40% of the stockfish product is lost due to poor process quality. Our idea is to develop an innovative indoor process line for the maturing and drying of stockfish equipped with an Automated Bioprocess Control System to assure seafood safety and quality and will be of use for quality drying of gutted and de-headed round fish in general. We propose to use innovative Microsystem Technology (MST) and developing a miniaturised low-cost sensing platform. An automated bioprocess control system will be developed to monitor and control the maturing and drying processes. This allows reducing the production time by a factor of 4, from 4 months down to 30 days by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'New methodology for the characterization of semiconductor self-assembled nano-structures with opto-electronic applications'.

assistant: **Objectives**

The aim of this project is to optimize the design and growth conditions of self-assembled semiconductor nanostructures with applications in micro- and opto- electronics. With this purpose, the candidate is going to develop a systematic methodology of analysis based in electron beam techniques and apply it for the study of these systems. The control on the structural features of semiconductor materials is essential for further technological developments, with high relevance for many aspects of our current society. In particular, the fabrication of structures with a high density of homogeneously sized self-assembled nano-motives is one of the challenges in this field because it supposes the achievement of laser emission with high intensity and mono-chromaticity.This project addresses absolutely one of the main thematic areas of the European Research Area of the FP6 (Nanotechnology and Nano-science) and is highly related to other one ('Information society technologies'). The innovative character of this proposal stems from the use of techniques with atomic column resolution such as high angle annular dark field scanning transmission electron microscopy (HAADF-STEM) for the optimization of the microstructure of semiconductor self-assembled systems. The researcher in charge in UC-Davis is a world reference of leadership in the use of HAADF-STEM for structural analyses, and UCA has recently acquired the required equipment for this type of analyses.Therefore, this fellowship will provide the applicant with high level skills in HAADF-STEM, which will be transferred to UCA in the third year, fulfilling the objectives of the Outgoing International Fellowship". The applicant has enough background knowledge both in semiconductor structures and in electron beam techniques to achieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Bioinformatics for Genomics in Malta'.

assistant: **Innovation**

BioGeMT will merge the strengths of the University of Malta (UM) in ICT and Genomics by hosting an expert Bioinformatician and Team within the Centre for Molecular Medicine and Biobanking, that will forge collaborations with existing highly specialised molecular genetics research groups. The goal is for UM to sustainably develop the field of Bioinformatics and the knowledge base and Machine Learning skills required to translate patient derived multi-Omic and clinical data into a better understanding of disease. The advancements made in high throughput -Omic technologies are locally hampered by a lack of bioinformaticians. There are benefits to rapidly developing bioinformatics in Malta: The population's genetic background and availability of large families is advantageous in elucidating the genetic basis of disease. The UM has expertise in biobanking, genetics, genomics and epidemiological research, enabled through strong ties with Mater Dei Hospital. BioGeMT complements and builds on previous investments (ERDF, TWINNING, local R&I funds) used to train researchers, build specialised labs and set up highly phenotyped disease-oriented sample collections with multi-Omic data, one with >2000 whole genomes and RNA-Seq data sets. Bioinformaticians would unlock the full potential of ongoing studies helping to overcome the problematic lack of genetic data from populations other than those of Northern European origin. BioGeMT would boost the international attractiveness, innovation and ability of the UM to compete successfully for international research funding, including IMI, Horizon Europe, charity foundations and industrial grants, by creating a highly specialised Bioinformatics centre in Southern Europe. In the long term this will increase the attractiveness of Malta to bioi