RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Disease-responsive Synthetic Cell Therapy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project aims to develop programmable, disease-responsive synthetic cells capable of sensing and adapting to pathological microenvironments—specifically hypoxia and acidity—by synthesizing and releasing therapeutic proteins on demand. Synthetic Cell Therapy, a novel class of precision medicine, will combine the adaptability of engineered living cell therapies with the precision and controllability of synthetic drug delivery systems. By leveraging the safety, modularity, and programmability of bottom-up synthetic biology, the proposed work addresses key limitations of current therapeutics, including immune rejection and uncontrolled behavior (engineered cell therapy), poor targeting and premature drug release (synthetic drug delivery system).Two complementary strategies will be explored: (1) gene circuit–mediated therapeutic synthesis and release, and (2) physicochemical multi-stage drug release. WP1 will develop stimuli-responsive gene circuits for in situ transcription–translation of therapeutic proteins and pore-formers within microfluidic-generated synthetic cells, enabling real-time, stimuli-triggered therapeutic action. WP2 will engineer multi-compartmental synthetic cells with membrane lipids responsive to hypoxia and acidity, enabling graded, multi-stage release based on disease severity. Together, these approaches offer lifelike adaptive therapeutic behavior with spatial, temporal, and dosage control.This interdisciplinary proposal integrates synthetic biology, microfluidics, biomembrane engineering, and pharmaceutical sciences, aligning with MSCA priorities in excellence, interdisciplinary and frontier research. The project addresses unmet medical needs in cancer and neurodegeneration and advances next-generation, safe, and intelligent precision medicine pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Neutron Spectroscopy with a Spherical Proportional Counter for precision measurements in deep-underground laboratories'.

assistant: **Objectives**

The concept of neutron spectroscopy dates back to neutron discovery in 1932. Despite several attempts towards an efficient neutron spectroscopy system, such measurements remain cumbersome and detailed neutron spectra are sparse both in scientific laboratories and industrial sites. To-date the most widely used method relies on the 3He(n,p)3H reaction, which - however - is more well suited for thermal neutrons and is particularly expensive, given that 3He is scarce. All existing alternatives are plagued by major disadvantages: toxic/corrosive gases, poor efficiency, limited radiation hardness, degraded energy resolution. The neutronSPHERE project will provide a unique alternative to 3He-based detectors for neutron spectroscopy by using the Spherical Proportional Counter (SPC), a high-gain large-volume gaseous detector, filled with a nitrogen-based mixture. The detection principle exploits the 14 N(n, α )B11 and 14 N(n, p)C14 processes, and exhibits all major advantages of 3He-based detectors, and goes beyond that to provide fast neutron spectroscopy at an affordable price. This breakthrough is enabled by novel developments in SPC instrumentation that the host has played a key role in demonstrating. The capabilities of the developed neutron spectroscopy system will be demonstrated in two application: Firstly, neutronSPHERE will provide the first high precision measurements of the neutron background spectrum in underground facilities. These will provide a unique insight and will immediately inform direct searches for Dark Matter. Then, neutronSPHERE will measure in situ the neutron-induced dose during proton therapy treatments, which is a crucial element in hadron therapy treatment and planning.


**Keywords:** Dark Matter direct detection, gaseous detectors, fast neutron s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Rhythm synchronization between music and spoken language'.

assistant: **Concept**

Rhythm perception is important for a wide range of higher cognitive abilities ranging from time perception to predicting the occurrence of future events, from perceiving language to dancing to the beat of the music. Despite considerable amount of research in rhythm in various scientific disciplines, the way the human mind perceives and produces rhythm is not fully understood. While many interdisciplinary studies look at how performance in one cognitive domain compares to performance in another, it has proven difficult to link the mechanisms for rhythm perception across perceptual and cognitive domains directly. This project therefore looks how rhythm in music and spoken language interact by relying on rhythm synchronization: i.e. the phenomenon that our mind tends to automatically synchronize our motor-activity to the rhythm we perceive auditory (e.g. tapping a finger to the beat of music, the gestures that accompany speech, and singing). Because rhythm in spoken language and music is shaped by experience with culture specific music and our native language, in addition to adults, this project also studies young infants from birth through the crucial early stages of vocal and motor development. The studies in this project rely on a combination of acoustic analyses and electrophysiological methods (sEGM) to determine how rhythm in language and music is synchronized, how synchronization unfolds in time and how differences in rhythm in the two domains affect rhythm synchronization. By looking at similarities and differences in the rhythm of spoken language and music, the project attempts to create a blue-print of the shared and domain-specific cognitive mechanisms necessary for rhythm processing. Because we are surrounded by rhythm in our everyday life, the study of rhythm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Organization and function of the axonal Endoplasmic Reticulum' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Brain function relies on neurotransmission at synapses, where local increases in calcium trigger the fusion of synaptic vesicles and release of their neurotransmitters. Decades of research yielded detailed knowledge on synaptic vesicles and the individual proteins that mediate neurotransmission. Conversely, we know surprisingly little about the synaptic contribution of the largest organelle in neurons: the Endoplasmic Reticulum (ER). Aberrant alterations in ER shape are, however, associated with many neurologic disorders, highlighting the importance of understanding the role this organelle plays in the neuron. Taking into consideration the mere quantity and range of specialized ER functions such as calcium signalling and lipid synthesis, the neuronal ER has received very little attention. I therefore strive to shed light on the major, unresolved questions of the field, namely what the ER protein composition is in synapses and how the ER contributes to important neuronal functions such as neurotransmission.To dissect ER function in neurons I will first characterize the composition of neuronal ER proteins and identify the key players that regulate ER degradation. Second, I will manipulate ER content, localization and degradation to understand how the ER contributes to neurotransmission and development. Finally, I will investigate the importance of ER and ER degradation for physiological and pathophysiological processes in vivo. To this end, I propose a multidisciplinary approach using advanced imaging techniques, endogenous protein tagging and proteomics to study ER function and its regulated degradation in neurons. These studies will yield innovative fundamental insights into the role of synaptic ER and thereby fill a crucial knowledge gap in neuroscience. Furthermore, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ELIN - The Electronic Newspaper Initiative' (ELIN) under Fifth Framework.

assistant: **Objectives**

ELIN will focus on personalisation of newspaper by development of interoperable solutions and a platform for flexible interactive news on demand request. Emphasis is on home environment, which mean focusing on easy to use, customisable, affordable and interoperable solutions and platform. ELIN will do this by embedding intelligence into vital process of Newspaper, supporting smart components for enhancement of ease of use and the day-to-day news update by e.g DVB, IP and wireless communication. But the integration of structure and information in order to reflect news-articles is not limited to this scenario. End users will not necessarily have to be at home to read the news; many will listen in a distributed way accessing what is required for their need through seamless interfaces between audio, video and image process for their interest. For them it is essential to have access to a group memory system that provides help with news access procedures and makes it possible to ask for complementary news from a media library (MPEG- 7) like from previous occasions.By the use of MPEG-4 producers of news will be able to make more interesting news and add interactivity to live news broadcasting for promotional advertisement. Scaleable solutions for advertisement in Electronic Newspaper not only on soft screens or on Interactive TV but also on different handheld computers and smart phones will provide the means for the industrial partners to provide this devices more or less free of charge. 3D advertisement will provide new user-friendly approaches for advertisement of Interactive Newspaper in combination with the interactivity possibilities of MPEG-4.To realise this, ELIN will develop the New-Media Toolkit by integration of existing services and develop new services. To support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Applying Fundamental Mathematics in Discrete Mathematics, Optimization, and Algorithmics""'.

assistant: **Concept**

This proposal aims at strengthening the connections between more fundamentally oriented areas of mathematics like algebra, geometry, analysis, and topology, and the more applied oriented and more recently emerging disciplines of discrete mathematics, optimization, and algorithmics.The overall goal of the project is to obtain, with methods from fundamental mathematics, new effective tools to unravel the complexity of structures like graphs, networks, codes, knots, polynomials, and tensors, and to get a grip on such complex structures by new efficient characterizations, sharper bounds, and faster algorithms.In the last few years, there have been several new developments where methods from representation theory, invariant theory, algebraic geometry, measure theory, functional analysis, and topology found new applications in discrete mathematics and optimization, both theoretically and algorithmically. Among the typical application areas are networks, coding, routing, timetabling, statistical and quantum physics, and computer science.The project focuses in particular on:A. Understanding partition functions with invariant theory and algebraic geometryB. Graph limits, regularity, Hilbert spaces, and low rank approximation of polynomialsC. Reducing complexity in optimization by exploiting symmetry with representation theoryD. Reducing complexity in discrete optimization by homotopy and cohomologyThese research modules are interconnected by themes like symmetry, regularity, and complexity, and by common methods from algebra, analysis, geometry, and topology.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Being on time saves energy continuous multimedia experiences on networked handheld devices' (BETSY), addressing dissemination and exploitation.

assistant: **Impact**

Wireless multimedia streaming on hand-held, mobile or otherwise battery operated devices will be a major technology underlying the next generation information and entertainment appliances. On one hand our own home slowly becomes a networked environment, in which devices can talk to each other. But wireless multimedia streaming will also become possible when we are on the move, as so-called hot-spots, places in city centres, bus stations, airports, hospitals etc, where our own devices can connect into a local networking area where services and content can be provided, will give the possibility to retrieve the content we want and have a reasonable amount of bandwidth available. Today it is not possible, even at design time, to make well-founded system trade-offs between network and terminal resource consumption, energy consumption of the terminal and timeliness of the streaming data.The BETSY project will deliver all the theory, models and design methodology to make this possible during design time and a framework implementation that makes dynamic adaptations in this trade-off possible at run-time. The latter part is necessary, as fixed system design is not possible anymore in the changing environment we look at. BETSY proposes to combine the research results of several domains, such as networking, device resource management, real-time processing and stream processing, to achieve a holistic view on the dependencies between bandwidth, delay, schedules, and the power and energy consumption for this specific application domain, because the traditional, isolated view of the issues does not yield satisfying results.The results will lead to reduced product cost by eliminating pessimistic and large safety margins or improved system performance with equal resource demands. It wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Calcium-sensitive functional Magnetic Resonance Imaging as a breakthrough technique to follow brain-wide intracellular calcium dynamics defining multi-scale neuronal activity' (BrainwideNeuroCaSens).

assistant: **Innovation**

Neuroscience’s ultimate goal of achieving a holistic understanding of brain function requires a cross-scale integration from single-cell physiology to global network topology. While remarkable achievements towards this goal have been made, brain research faces the challenge of incorporating molecular and cellular neurobiology into the context of macro-scale network activation. Calcium is a reliable marker of neural activity and calcium imaging is among the most widely used methods in modern biology, although the technology for measuring large-scale calcium dynamics remains limited. BrainwideNeuroCaSens seeks to pioneer magnetic calcium-responsive sensors in the context of functional magnetic resonance imaging (fMRI) as a tool for a brain-wide interrogation of neural systems, providing an order of magnitude speed increase and a neurophysiologically precise readout, thereby far surpassing other noninvasive neuroimaging methods. These magnetic calcium-responsive sensors with physicochemical properties similar to optical imaging dyes, make use of the whole-brain, noninvasive imaging capabilities of fMRI and allow to detect translationally relevant, molecular precise correlates of neuronal activity in otherwise inaccessible deep structures and large regions of the mammalian brain. While focusing on dynamic functional connectivity relationships to study stimulus-responses and intrinsic network dynamics, the proposed experiments have significance for understanding brain-wide neural circuits in health and disease, offering pre-clinical potential for neurodegenerative pathologies. BrainwideNeuroCaSens’ offers a molecular precise readout of global neural network function and thereby opens the possibility for therapeutic strategies aiming at a restoration of network disruptions, f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hypoxic renal proliferation' (PROLIGEN) under Sixth Framework.

assistant: **Objectives**

PROLIGEN aims to enhance the endogenous regenerative capacity of injured kidneys based on information derived from genomics/proteomics and functional genomics. The approach of PROLIGEN is: a) To define and identify set of genes/proteins associated with functional recovery from renal injury. b) To build up high throughput test systems to follow the basic biological process involved in regeneration and to use these read out systems for functional genomics. And c) to develop biologicals and cell based therapy to foster proliferation. PROLIGEN differs from previous approaches in that we split the regeneration process into the different main biological process (apoptosis, formation of pro- versus anti-inflammatory mediators/macrophage phenotype and cell proliferation), and we aim to study regeneration as the result of their interdependence. We take into account that macrophages are at the centre of a complex regulatory network receiving and distributing signals from and to all biological process, thus affecting recovery. At variance with previous studies we particularly focus not only on the identification of markers relevant for regeneration rather than the use of functional genomic technology which provide a new network of gene function and new platforms to deliver a new cellular based therapy strategy. Experiments will be carried out in vivo and in vitro using rodent, tubular cell and macrophage culture. Genomics, functional genomics and recombinant protein synthesis SMEs and prominent experts in fundamental biological process associated to the renal ischemia/reperfusion and regeneration processes will provide the necessary knowledge and critical mass to reach the goal of this project; namely and foremost, the development of intervention strategies for amelioration of acu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Experimental ecology of fish - competitive interactions between young of the year roach and perch' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The perch (Perca fluviatilis)-roach (Rutilus rutilus) system in European lakes is among the best known freshwater fish communities. Still, the ecology of the youngest stages of these two species has been much less investigated especially at the experimental level. Although major members of European fish communities overall, perch and roach are not native to the Iberian Peninsula, but have recently been introduced into a few localities in Catalonia. The two general objectives of the proposal include: i) experimental studies in lake enclosures on competitive interactions between young-of-the-year roach and zerch; and ii) the assessment of exotic fish impact on Spanish freshwater assemblages. The well-developed conceptual framework for the perch-roach interaction will provide an exceptional opportunity for predicting and understanding changes due to the invasion by these new species on the Iberian Peninsula.