RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dissecting early Skin-based immune responses to PARasites in ControLled human infection studies to design novel vaccines' (SPARCL) targeting Horizon Europe.

assistant: **Abstract**

Parasitic diseases cause considerable morbidity and mortality in poverty-stricken areas, affecting hundreds of millions of lives globally. Vaccines are urgently needed to alleviate disease and lift the economic consequences. Plasmodium falciparum malaria, Schistosoma mansoni and Necator americanus hookworms are together responsible for the greatest burden of disease. Vaccination with attenuated parasites is an efficacious strategy in inducing immunity to parasites in animal models. Recently, we have translated attenuated parasite vaccination to humans in proof-of-concept clinical trials in which we protected subsets of individuals from challenge. This unique preliminary data indicates a role for the skin as a prime immunological organ. Based on these findings, I propose to create a next generation highly immunogenic, adjuvanted whole parasite vaccines, ready for pre-clinical testing. We will build on our previous experience with chemical tools to load whole parasites with adjuvants. To measure the potency of the new vaccines, we aim to measure early skin-based humoral and cellular immune markers which correlate with protection in our samples from prior and novel controlled human infection models. We will assess the functionality of antibodies by adapting our current molecular imaging tools to quantitatively analyze movement kinematics of parasites in representative 3D environments resembling the human skin. Cellular correlates of protection in skin will be mapped using imaging mass cytometry on freshly obtained skin biopsies from experimentally infected volunteers. Through combined, parallel analysis of circulating immune markers by high-dimensional flow cytometry, we aim to take a comprehensive approach including local and circulating markers to identify protective imm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exoplanet Athmosphere New Emission Transmission Spectra Analysis' (2014-2020).

assistant: **Concept**

The last twenty years have witnessed an exceptionally fast development in the field of the extra solar planets. The known exoplanets, 3500 to date, already show how diverse the planets in our galaxy can be. While the detection of exoplanets is an important ongoing field of activity, the characterization of their atmospheres has just begun and it is developing very rapidly. A lot can be learnt from spectroscopic observations of an exoplanet atmosphere; the molecular composition of giant exoplanet atmospheres can trace the planet's formation and evolution; the atmosphere of rocky exoplanets can host biosignature gases... However, the observations are challenging because the signal is often embedded in instrumental and telescope systematic noise. In the ExoplANETS_A project, we will develop novel data calibration and spectral extraction tools, as well as novel retrieval tools, based on 3D models of exoplanet atmospheres, to exploit archival data from ESA Space Science archives (HST) combined with NASA Space Archives (Spitzer, Kepler) and produce a homogeneous and reliable characterization of exoplanet atmospheres. Additionally, to model successfully the atmosphere of an exoplanet, it is necessary to have a sound knowledge of the host star. To this end, we will collect a coherent and uniform database of the relevant properties of host stars from ESA Space Science archives (XMM, Gaia), combined with international space mission and ground-based data. These exoplanet and host star catalogues will be accompanied/interpreted with models to assess the importance of star – planet interactions. The knowledge gained from this project will be disseminated through peer-review publications and modelling tools will be publicly released.In addition to the delivery of high level data prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Access to Large Infrastructures for Severe Accidents' (ALISA).

assistant: **Concept**

Enhanced transnational access to large research infrastructures in Europe and in China is offered to allow the optimal use of the resources in the extremely complex field of severe accident analysis for the existing power plants. This research involves very substantial human and financial resources and, in general, the research field is too wide to allow investigation of all phenomena by any national programme. To optimise the use of the resources, the collaboration between nuclear utilities, industry groups, research centres and safety authorities, at both European and Chinese levels is very important. This is precisely the main objective of the ALISA project, which aims to provide these resources and to facilitate this collaboration by providing large scale experimental platforms in Europe and in China for transnational access.Large-scale facilities offered for access in the project are designed to resolve the most important remaining severe accident safety issues, ranked with high or medium priority by the SARP group for SARNET NoE. These issues are coolability of a degraded core, corium coolability in the RPV, possible melt dispersion to the reactor cavity, molten corium concrete interaction and hydrogen mixing and combustion in the containment. The major aspect is to understand how these events affect the safety of existing reactors and how to deduce soundly-based accident management procedures.Activities within the ALISA project will focus on the large scale experiments under prototypical conditions addressing the remaining R&D issues on severe accident management in light water reactors. ALISA offers a unique opportunity for all parties to get involved in the networks and activities supporting safety of existing and advanced reactors and it allows European and Ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanoparticle - Cell Interactions, a Pathway for Understanding Nanotoxicity:  from a Model System to in-vitro System' under Seventh Framework.

assistant: **Concept**

While nanotechnology-based products and nanoparticle mediated solution for a wide range of applications are constantly surface the market, there is increased interest and concern, around the benefits and risks of this technology. As nanoparticles size crosses the barrier of 100 nm, many of the traditional laws break down and other effects and properties start dominating (quantum size effects, extremely high surface energy etc). This raises questions regarding the suitability of traditional methods, such as in-vitro test kits and in-vivo animal models used to evaluate their potential toxicity. It is therefore essential to understand the cell - nanoparticle interaction at a fundamental molecular level in complex or simplified biological environments in order to asses their potential toxicity. Further on this foundation the modulation of the nanoparticle properties will allow for optimal performance in drug delivery, bioimaging, medical device coatings, bio-sensors, biochip development, biofouling protection and mitigate nanotoxicology.The major aim of this research endeavor is to study and understand the interactions that take place at the nano-bio interface, as a function of the particle size and the proteins from the biological environment that have been adsorbed on the surface of the particle. To achieve that we propose the utilization of two state of the art surface sensitive techniques; ie the Atomic Force Microscope and the Acoustic Biosensors, that will be used either separately or in combination for the study of the the interaction force and the structural changes that occur. Initially these interactions will be studied on a simplified membrane model, to avoid complex interactions, a supported lipid bilayer, in order to understand the foundation of these interacti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of nickel-free titanium based shape memory alloys for biomedical applications' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This proposal is prepared with the help of an Exploratory Award, which included a Research Feasibility Study. The report on the study is included in this proposal. This project addresses a new concept in speciality materials for medical applications. Continuing advances in the areas of clinical science involving the use of implants inside the human body, have created demand for materials that need to satisfy the twin needs of biocompatibility and special properties, such as the shape memory effect and superelasticity. Titanium Nickel based alloys possess the aforementioned properties and their use is rapidly gaining acceptance. Nickel however, is well known to cause adverse effects to the body, i.e. allergenic reactions. Although biocompatibility tests have not detected adverse effects, complete removal of nickel from shape memory alloys would eliminate the chance of any toxic effects. Additions of elements, such as zirconium, niobium, tantalum and platinum, which are essentially biocompatible, when alloyed with titanium may exhibit the shape memory effect. This research programme is designed to identify suitable alloys in this group, which would have all the beneficial shape memory effects of the titanium nickel based alloys and also reduce adverse biological responses.Whether a good combination can be found is still a risk, because the shape memory ability depends on close tolerances regarding alloying and production processes. This project would produce an alloy that is more attractive to the medical profession. Indirect benefit is that indications are given that the alloy possesses better properties with regard to formability. It may increase the use of titanium based memory alloys in new applications such as implanted drug delivery systems, endoscopy, laproscopy. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Insect cochlea: a non-invasive path towards enhanced sound detectors' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

There is a critical need for high-resolution acoustic sensors for numerous applications in engineering/medicine.  The human cochlea has been a source of inspiration for acoustic sensors due its improved sensitivity, higher frequency range, and sharp frequency discrimination. Current methods for measuring cochlear mechanics are inherently invasive, and deep understanding of its process remains elusive, proving challenging its simulation in electromechanical devices. Yet cochlear organ for frequency selectivity is not unique to mammalian audition. A simpler analogous mechanism for frequency analysis was recently found in the ears of bush-crickets (insects). These insects are endowed with outer middle and inner ear, but unlike mammals their cochlea is small (~0.6 mm), uncoiled, and exceptionally accessible through transparent cuticle. These attributes facilitate the clean measurements of complex auditory processes impossible to attain in the mammalian cochlea, and open an exceptional opportunity for miniaturization and simplification of artificial acoustic sensors.Using bush-crickets and relatives as model systems this project is designed to fulfil the following two main objectives: (1) to dissect the three ear components to i) identify the elements involved in acute hearing sensitivity, ii) characterise the role of multiple sound inputs in directional hearing, iii) associate the activation patterns of auditory afferents with mechanical waves in the insect cochlea. (2) Use experimental data to produce computer models and theoretical analogues of the insect cochlea to propose innovative alternatives in the design of acoustic sensors. By using a multi-disciplinary approach between biology, engineering, physics and mathematics, this project is designed to develop new technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Metabolic Regulation of Conventional Dendritic Cell Development and Function'.

assistant: **Objectives**

Dendritic cells (DCs) play critical roles in directing innate and adaptive immune responses against infections and cancer. Understanding the mechanisms that control DC development and function may reveal new ways to alter the course of complex human diseases such as cancer. Despite their importance in immunity, some open questions remain in regards to DC basic biology. Two of these questions, in particular, are the subject of this application: 1) DCs are a heterogenous population, which can be subdivided into conventional DC type 1 (cDC1) and 2 (cDC2) subsets. Although their development depends on distinct transcriptional programs, cDC1 and cDC2 descend from a common precursor under the influence of the same growth factor cytokine. What determines cDC1/2 differentiation? 2) Various loss-of-function studies demonstrate that cDC1 are key antigen-presenting cells for initiating CD8+ T cell responses to tumours and some viruses. This primarily relies on a process termed cross-presentation. How is cross-presentation regulated in cDC1? Recent studies indicate that profound changes in cellular metabolism are coupled to immune cell function and may fundamentally underpin cell-fate decisions. Based on previous observations and our own preliminary data, we hypothesise that glycolysis programs cDC1 development and activation, whereas fatty acid metabolism controls the ability of the same cells to cross-present antigens to CD8+ T cells. We propose to define the metabolic programs that drive DC formation and that underlie cDC1 and cDC2 identity and complement this approach with loss and gain-of-function experiments that will allow specific testing of our hypotheses. Globally, these studies will identify novel mechanisms of immune cell control with implications for antiviral and anti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Alternative life histories: linking genes to phenotypes to demography'.

assistant: **Innovation**

Understanding how and why individuals develop strikingly different life histories is a major goal in evolutionary biology. It is also a prerequisite for conserving important biodiversity within species and predicting the impacts of environmental change on populations. The aim of my study is to examine a key threshold phenotypic trait (alternative migratory tactics) in a series of large scale laboratory and field experiments, integrating several previously independent perspectives from evolutionary ecology, ecophysiology and genomics, to produce a downstream predictive model. My chosen study species, the brown trout Salmo trutta, has an extensive history of genetic and experimental work and exhibits ‘partial migration’: individuals either migrate to sea (‘sea trout’) or remain in freshwater their whole lives. Recent advances in molecular parentage assignment, quantitative genetics and genomics (next generation sequencing and bioinformatics) will allow unprecedented insight into how alternative life history phenotypes are moulded by the interaction between genes and environment. To provide additional mechanistic understanding of these processes, the balance between metabolic requirements during growth and available extrinsic resources will be investigated as the major physiological driver of migratory behaviour. Together these results will be used to develop a predictive model to explore the consequences of rapid environmental change, accounting for the effects of genetics and environment on phenotype and on population demographics. In addition to their value for conservation and management of an iconic and key species in European freshwaters and coastal seas, these results will generate novel insight into the evolution of migratory behaviour generally, providing a text b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The development of a novel laser-inkjet hybrid printing technology for additive printed, high resolution, mass customised conductive copper tracks' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

We intend to enable greater competitiveness and internationalisation of the SME dominated printing community. There are some 68,000 EU SME's in the printing sector, 6% (4,000) of which we use laser or InkJet printing systems to print products such as plastic films for in mould labelling, packaging, and smartcards. The proposed technology could enable these printers to sell their services into an entirely new, and much higher added value application; printing flexible electronic circuits as components for manufacturing industry.In addition, SMEs already in the electronics sector, of which there are 17,500 which could also exploit the proposed technology to add functionality to the circuits they currently manufacture in-house. The printing industry is characterised by SME providing varying printing services from large format through to commercial printing of company brochures. The vibrant growth in the Asian printing market of 10.6% has resulted in a reduction in growth of the European printing industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable sewage sludge management fostering phosphorus recovery and energy efficiency' (P-REX) under Seventh Framework.

assistant: **Objectives**

Phosphorus is one essential element of life, which can neither be produced synthetically nor substituted by any other substance. Its importance as plant nutrient is emphasized by the huge amount of 975 000 tons of phosphorus annually imported into Europe to sustain good harvests. While phosphorus is a limited fossil element, its extensive recovery from “secondary deposits” is of paramount importance and follows the principles of the European Roadmap for Resource Recovery. Municipal wastewater represents a relevant phosphorus reserve and has the potential to cover about 20% of the demand. Technology concepts have been developed in recent European projects to tap into this local resource. While the traditional application of sewage sludge in agriculture is increasingly refused by stakeholders, this path has to be further secured to protect the environment and human health. In addition, technological alternatives to recycle phosphorus are available and need yet to be deployed on to the market. The P-REX project builds on the outputs of previous European research projects and will perform the first holistic full-scale evaluation of technical phosphorus recovery techniques using municipal sludge or ashes in comparison with phosphorus recycling by land application of sewage sludge. The technical, operational and economic data as well as a comprehensive ecotoxicological and plant-availability assessments will provide the basis of comprehensive life cycle and life cost assessments of phosphorus recovery processes. Complementing a market analysis, a guidance document for policy makers and end users will show the best phosphorus recovery options depending on regional conditions and illustrated by selected case studies. The results of the project will be extensively disseminated i