RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Icsc-2000' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim of the international crop science congress is to contribute to the objectives of the Thematic Programme Quality of life and management of living resources" on the European as well as on the global level. After two successful previous meetings (USA in 1992 & INDIA in 1996) the European Society of Agronomy (ESA) accepted the invitation to organize the Third International Congress to strengthen the transfer of knowledge within Europe and the international scientific communities.The congress will focus on sustainable and multifunctional land use and on future food security, in the context of the rising demand for crop products in the decades to come. Furthermore, the effects of increased crop production on the natural resource base and the environment will be addressed. Science-based innovations in agricultural technology, plant production systems and products are essential to meet the future needs of society. Four themes have been selected for the Congress agenda."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Selective vulnerability of neuronal degeneration in Parkinson’s disease: the load of routine behaviour' under Horizon 2020.

assistant: **Concept**

Parkinson’s disease (PD) is characterized by striatal dopamine (DA) depletion due to loss of dopaminergic neurons in the Substantia Nigra pars compacta (SNpc).Understanding the mechanisms underlying the onset and progression of SNpc damage is a primary unmet goal in PD research.Cell loss occurs earliest and foremost in the ventro-lateral region of the SNpc.Previous work defines anatomical factors determining the vulnerability of the ventro-lateral SNpc:their large axonal arborisations,bursting activity with high Ca++ inflow,high oxidative stress and sensitivity to aging.However, all of these features are shared by SNpc neurons but neurodegeneration in PD begins specifically by the ventro-lateral tier. This DA depletion first occurs in the posterior striatum, which is involved and required for habit formation and routine behaviour.Indeed, the earliest motor features of PD are commonly associated with impairment of automatic movements.The striatum is well known to be engaged in learning and habit formation,a process that is DA dependent.Striatal DA is released phasically (SNpc firing related) triggered by emotional responses,whereas tonic dopaminergic modulation (non-SNpc firing related),predominates in routine behaviour. The precise mechanism whereby DA regulates the learning of a routine is not well defined but SNpc dopaminergic neurons are engaged in behavioural tasks showing an activation of their firing rate at the start of an instrumental task. This provides support to the notion that DA signals the onset/offset of a task and perhaps switching between tasks.In addition, they have a higher response to external stimuli (alertness, sensory) and to emotional behaviours (i.e. reward, salience). It is hypothesized here that in order to control the whole spectrum of a task
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Models for Lignocellulose Thermochemical Conversion' (Mod-L-T).

assistant: **Innovation**

Chemicals, fuels and energy must be produced from lignocellulosic plant-matter if global economies are to decarbonise. To be successful, these lignocellulose-derived products must compete in technical quality and price with fossil derived products. Thus, we must understand what lignocellulose is, and how its chemical structures react in thermochemical processing technologies, such as pyrolysis. Pyrolysis is a promising method to produce valuable products from lignocellulose and the basic fundamental process of more complex thermochemical technologies, such as catalysis. Mod-L-T deciphers the elementary reaction mechanism and kinetics of lignocellulose pyrolysis. Relative to cellulose, the reaction kinetics of hemicellulose and lignin are less studied, and thus the focus of Mod-L-T.Mod-L-T creates the first detailed, elementary, mass- and energy-conserved chemical reaction model for lignocellulose pyrolysis. A compositional characterisation and modelling procedure utilising Nuclear Magnetic Resonance spectroscopy identifies what molecular structures comprise, and best represent actual lignocelluloses. The mechanism and kinetics of the pyrolysis reaction of the identified hemicellulose and lignin functionalities are then rigorously and systematically determined by the study of model molecules of incrementally increasing structural complexity, up to actual hemicellulose and lignin structures. Experimental and theoretical means are coordinated; A Thin Film Reactor obtains kinetically limited isothermal reaction rate and time-resolved evolved species information. Potential Energy Surfaces are determined by the M06-2X/6-311++G(d, p) methodology. This new fundamental knowledge is assimilated by the construction of detailed reaction kinetic models for hemicellulose, lignin and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Blocking a6 integrin cleavage as a therapeutic target for prostate cancer bone metastases' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Prostate cancer affects people all over the world. The most frequent site of prostate cancer metastasis is the bone and once it has metastasised it is incurable and extremely painful. The goal of this proposal is to develop new therapeutic tools for palliative care for bone metastases. Our model states that the high levels of uPA in the bone induce cleavage of the a6 integrin in prostate cancer cells, leading to the activation of other integrins (such as a2, a3 and av) to allow for migration and homing on the bone matrix. In this proposal, we will investigate whether the a6 integrin cleavage by uPA controls cell adhesion by integrins other than the a6 integrin, a process referred to as integrin switching".In addition, we will investigate whether the a6 integrin cleavage by uPA controls migration through focal adhesion signalling. First, we will test the hypothesis that blocking the cleavage of the a6 integrin will reduce osteoblast conditioned media (OBCM) induced adhesion of prostate cancer cells on b one matrix. We will test this by using a peptide and an antibody designed to prevent a6 integrin cleavage and we will also perform transfections of an uncleavable a6 integrin mutant in the PC3 prostate cancer cell line. We will evaluate changes in adhesio n on different substrates (collagen, vitronectin and osteopontin) using cell adhesion assays. Second, we will test the hypothesis that blocking the cleavage (using a peptide, an antibody and transfections) of the a6 integrin will reduce the phosphorylation levels of FAK, Pax and p130CAS upon OBCM stimulation.Third, using the peptide, the antibody and the transfections in the PC3 cell line, we will investigate the role of the a6 integrin cleavage by uPA in cell migration and invasion upon OBCM stimulation . Migration will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Deciphering the role of thyroid hormones in seasonal reproduction'.

assistant: **Concept**

Most mammals living at temperate latitudes exhibit seasonal reproduction, which is synchronized by photoperiod through the central action of melatonin. In the ewe this translates into the initiation of the breeding season as day-length shortens while the anestrus season is triggered by the photoperiod lengthening, which occurs at the end of winter. We recently characterized a complex pathway by which melatonin acts in the rostral part of the pituitary, known as the pars tuberalis, to yield a local increase of triiodothyronine (T3) within the adjacent medio-basal hypothalamus (MBH). This mechanism accounts for early observations that T3 increase within this region is mandatory for anestrus to occur. Building on these findings, this research program aims at a thorough characterization of the downstream events which ultimately tie the local increase in T3 to the shutdown of the gonadotropic axis. I propose a transcriptomics approach to reveal T3 target genes within the MBH and decipher how their photoperiodic control eventually impacts on the activity of GnRH neurons. Since the long-term objective of this work is to obtain out-of-season lambing without adverse hormonal treatments, the identification of T3 target genes will provide us with potential levers. The use of genetic databases in different ovine breeds presenting varying degrees of seasonality will help to assess the physiological role of these genes and lead to an improved genetic selection. The increase of T3 within the MBH requires the presence of its precursor, the thyroxine T4, in the cerebrospinal fluid. Since T4 gains access to the CSF through the choroid plexuses, the latter constitute another potential target to modulate seasonal reproduction. Therefore, we will also evaluate the impact of photoperiod on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Noč ima svojo moč, European Researchers’ Night (NIGHT)' (NIGHT).

assistant: **Innovation**

Noč ima svojo moč [The Night has it might] (NOCMOC) [NIGHTMIGHT] project combines a strong awareness campaign embedding a major media campaign and a citizen science project with activities spread all over Slovenia in the two Researchers nights in 2018 and 2019. The core objectives of the NOCMOC project is to raise awareness about the research and its benefits, overcome stereotypes, stimulate curiosity all over Slovenia and excite youngsters to take up the research careers.The awareness campaign will comprise national TV broadcasts, radio broadcasts, press presence and a social media campaign, reaching 100.000 people. Moreover, as a citizen science project, over 500 seeds will be sown all over Slovenia by citizens and will be the basis for collaboratiovecollaborative research: comparing growth, plants characteristics and the physical and chemical properties of Slovenian autochthonous species. We expect seeds to grow throughout the citizens science project in the awareness campaign and to bloom on the Researchers’ night.The NIGHT activities will take place in 17 cities across Slovenia and will bring together 27 research-related institutions to raise awareness about research and innovation, its social and economic benefits as well as its variety of careers. Over 40.000 visitors from different target groups will take part in the NIGHT activities spread all over Slovenia. Activities will combine science festivals on the main square of four cities, research days in 6 primary and secondary schools, over 30 lectures and workshops in public spaces such as libraries, retirement homes and museums, open doors at the research institutions, science centre and cultural institutions.


**Keywords:** research, innovation, science communications, researchers, participatory event, citizen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of climate change on past human living conditions: Resource acquisition strategies and landscape use in eastern Central Europe from the Gravettian Golden Age to the Last Glacial Maximum' (COPE).

assistant: **Innovation**

Climate change, and thus environmental change, is one of the major challenges of all life forms. This was particularly the case in the Late Pleistocene (129,000–11,700 years ago), when the amplitude, frequency and severity of climate change was intense, making environmental conditions unpredictable and unprecedented. Animals respond differently to these challenges – affecting adaptability, ecological tolerance and behaviour. In the history of our species in Europe, these challenges became most pronounced in the period leading up to the Last Glacial Maximum (LGM). Yet, very few prehistoric sites preserve records that span the whole period or preserve organic remains, thus limiting our understanding of how local human groups responded and survived. One exception is Grub-Kranawetberg, a site that not only preserves rich archaeological strata that span the entire onset of the LGM, but also has exceptional organic preservation, including a rich floral record. COPE aims at applying a range of techniques that bridge traditional archaeology and cutting-edge archaeological science to explore the lithic, faunal, floral and hydrological records from this extraordinary site, and throw light on human behavioural resilience to climate change. COPE uses recent advances in sedimentary biomarkers, oxygen isotope and aDNA analyses to gain a novel, comprehensive view of both past local environmental conditions and environmentally-driven adaptive responses in the exploitation of a mosaic of resources. Gained insights will, in turn, be used to re-evaluate regional archaeological records that lack organic preservation. Ultimately, by investigating what strategies ancient populations employed that maximised inert and living resources in the face of extreme climate change, COPE offers a highly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Real-time nanoscale manipulation of  structure and environment to understand light-harvesting regulation in photosynthesis' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Sunlight is a source of life for plants but also of photodamage. To harvest solar energy “safely”, plants have developed a nanoscale mechanism controlled by small proteins which bind pigments, called light-harvesting complexes (LHCs). At low light intensities, the LHCs harvest and transport solar energy to the sites of photochemistry. Under intense light, LHCs switch function to dissipate excess energy as heat. Through this photoprotective switch, the LHCs efficiently protect plants from photodamage.Yet, how do plants activate the LHC photoprotective switch? Current models assume that the switch is driven by protein conformational changes of the LHCs, regulated by the environment through pH changes and interactions with protein and cofactors. However, no experimental tool implemented in the field of photosynthesis allows to identify the conformational changes responsible of photoprotection and to determine how the environment controls them – limiting our mechanistic understanding of light-harvesting regulation in plants.I will tackle this challenge by:1) Pioneering the study of LHC nanomechanics via single-molecule optical tweezers, resolved in force and fluorescence, to track LHC conformational changes at single-residue level and identify those driving the photoprotective switch.2) Leveraging a novel ultrafast multipulse spectroscopic tool — just developed by my group — to rapidly control environmental changes and determine the intermediate steps in the photoprotective switch of the LHCs.3) Integrating ad hoc molecular dynamics simulations to map how external physiological factors tune the conformational landscape of the LHCs.By implementing a novel optical and computational toolkit, I will advance our understanding of how plants regulate light harvesting at the nanosc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Adaptive Business Collaboration by progressive knowledge sharing and engineering' under Seventh Framework.

assistant: **Concept**

The vision of TRANSPARENCY is to allow European machine-tool builders for transferring their business into a machine-related cooperation of service oriented partners in a dynamic network. The project aims for a vertical integration of management, design and operation of machine-tools to provide long-ranging transparency for both the end users and the machine-tool builder throughout the whole life-time of the machine-tool. This is achieved by a knowledge based Collaborative Co-Design Environment approach using semantic technologies. Special attention will be paid for the conceptual system design stage, the feed-back of knowledge from the operational life-cycle stages. Life-cycle performance, knowledge about produced products, and experiences of human personnel will be constantly incorporated into the set of knowledge. Handling of complexity will be achieved by self-descriptive Active components and the realization of a flexible, knowledge based Co-Design Methodology. Advanced assessment and prediction tools with links to commercial of the shelf simulations will assess important key performance indicators to execute virtual test cases to support especially early design decisions. This will drastically reduce costly re-design cycles in detailed design. Furthermore, the continuous availability of dynamically assessed Life-Cycle Costing data will allow for constant total life cycle cost optimization of the machine-tool and its components. Via web-based collaboration and secure storage of data, the project will ensure that every responsible stakeholder will have access to all information available throughout the whole life-time of the product and towards the re-use or disposal of the machine-tool or its components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EuroScience Open Forum 2020 Trieste' (ESOF2020).

assistant: **Concept**

The EuroScience Open Forum has been created in 2004 by EuroScience. It’s dedicated to scientific research and innovation and offers a unique framework for interaction and debate for scientists, innovators, policy makers, business people, science media and the general public. The 9th edition of ESOF will take place in Trieste (Italy) from the 5th to the 9th july 2020, while the “City in the city Festival” will take place from the 27th june to the 11th of july 2020. The motto of this edition is: “Freedom for science, science for freedom”. ESOF’s Scientific Programme me will deal with major European and world challenges, tackling the following topics: Sustainable future, Breaking frontiers, Nourishing the planet, Science and Society, Science for policy/Policy for science, Live long and prosper, the Blue planet, I compute therefore I am, and the Smart City.  This edition of the Forum will gather more than 4000 participants. Special effort will be dedicated to enhance the participation of people coming from the Central-Eastern European countries, with a target of plus 10% of participants. The Scientific Programme is complemented by five other programmes:-  the Science for Policy/ Policy for Science Programme, which addresses policies on science for Europe;-  the Career Programme, which is geared specifically towards young European researchers and new future jobs;-  the Science to Business Programme, which addresses the involvement of the private sector in science and innovation and its dialogue with scientific research; -  the Media and Communication Programme, which targets media involvement in all forms with a specific agenda dedicated to science communication;- the Science in the City Programme which provides a scientific cultural programme to engage with the general publ