RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optical real-time imaging of inhibitory GABAA receptors activity using chimeric GABA channel subunit' (ImagingGABA).

assistant: **Innovation**

In mammalian brain the main inhibitory drive is determined by GABAergic synaptic transmission. Released from presynaptic terminals GABA activate postsynaptic Cl-selective GABAA receptors, which results in hyperpolarization of cells and inhibition of neuronal network. Dysfunction of GABAA receptors may lead to a number of pathologies, including epilepsy, Alzheimer’s disease, sleep disorders and schizophrenia. The main approach for functional analysis of GABAA receptors is represented by electrophysiological methods. An alternative approach would be to use non-invasive fluorescent analysis of GABAA receptors activation, which requires creation of new probes. We propose to design genetically encoded Cl-sensitive sensors capable to monitor activation of Cl-selective GABAA receptors.  We will develop the probe “BioSensor-GABAR”: a chimeric GABAA receptor subunit with Cl-Sensor inserted to cytoplasmic domain. Development of “GABAR-Sensors” would allow us (i) to monitor activation of the GABAA receptors (ii) to estimate [Cl-]i in the local areas in close vicinity of the GABAA receptor clusters and (iii) to visualize GABAergic synaptic networks during different patterns of neuronal activity.Given the diverse roles of GABAergic signaling in the brain including; hyperpolarisation, decreasing excitability, shunting inhibition, tonic inhibition, disinhibition, and modulation of oscillatory activity it is not clear a priori what the effects of the change in GABAA receptor activity will be on a particular neuronal network. Creation of BioSensor-GABAR will make an important step to the understanding of the physiology of inhibitory neurons and neuronal networks functioning. Results to be obtained in this project will shed light on the functional role of particular classes of GABAergic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Demographic Responses tO Varying Environments under climate change' (DROVE) targeting Horizon Europe.

assistant: **Abstract**

Ongoing climate change has altered both mean and short-term temporal variability of environmental conditions (such as temperature or food resources). While there is strong evidence that wild populations are deeply influenced by changes in the mean environmental conditions and respond accordingly (e.g., shifts in phenology, in species ranges), population responses to changes in the magnitude of environmental fluctuations are poorly understood. This knowledge is, however, crucial to better predict and anticipate climate change impacts on biodiversity. Hosted at the Institute of Mathematics of Bordeaux (University of Bordeaux), the project DROVE will be coordinated by Christie Le Coeur, a specialist in population ecology, who will benefit from the supervisors (Dr. F. Barraquand) expertise in ecological statistics and theory. This project aims to provide a robust statistical and theoretical framework to unravel the effects of changes in environmental variability on dynamics of wild populations, and to characterise the demographic mechanisms responsible for their persistence under climate change.This goal will be achieved by defining metrics to measure population persistence and demographic strategies in a variable but also density-dependent environment (when population growth slows down as population density increases) as previous work on variable environments has ignored this almost ubiquitous population regulation. The researcher will then build population models with data from long-term, individual-based population datasets of a well-studied species across Europe, the great tit (Parus major), to explain intra- and inter-population variations in demographic strategies and persistence in varying environments. Combining long-term empirical surveys with state-of-the-art mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Introduction of lightweight, low cost, hi-impact performing composites into the furniture industry' under Fourth Framework.

assistant: **Concept**

Task1 Components selected for prototyping; prototype performance criteria characterised; Health and Safety and environmental legislation governing established processes identified (this legislation also governs the handling and use of thermoplastic composites); SMEs visited to establish design philosophy for designing prototypes, and to identify ability to introduce new technology into existing manufacturing environments.Task2 Detailed design and concept evaluation of identified prototypes; primary prototypes manufactured; manufacturing technology identified; primary prototypes evaluated; secondary prototypes designed.Task5 Surface finishes identified; surface finishes sourced; determination of application parameters for surface finishes; trials with surface finishes to determine best application techniques; evaluation and report on performance of surface finishes.Task6 Evaluation of environmental effects of existing processes and new technologies; evaluation and report of environmental study parameters (life cycle assessments).The objective of the project is to develop thermoplastic composite materials for the production of furniture in the educational, institutional and contract banking sectors. The material will have endurance characteristics and the ability to withstand abuse. Most traditional materials use within this sector are less flexible, less manipulative, heavier and are unfavourable to designers and product developers. The innovation will concern the recent advances in thermoplastic composite moulding technology which has resulted in the development of materials and processing techniques which are emission free. Additional benefits in terms of higher produdivity cost effectiveness and recyclability have also been demonstrated when compared to established pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanoassemblies for the subcutaneous self-administration of anticancer drugs' (THERMONANO) targeting Horizon 2020.

assistant: **Abstract**

To counter the predicted drastic rise of new cancer cases over the next decades and to lower the dramatic financial burden of cancer treatments on patients and healthcare systems, innovative chemotherapies with high efficacy and reduced cost represent an urgent and unmet clinical need. Despite great enthusiasm for drug-loaded anticancer nanocarriers (e.g., liposomes, nanoparticles, micelles), their bench-to-bedside translation is not straightforward. Recent disappointments during clinical trials have fuelled concerns as to whether drug-loaded nanocarriers work any better than the free drugs. Thus, significant rethinking of drug delivery from nanocarriers seems inescapable. In the context of THERMONANO, I will develop a new drug delivery strategy that will be simple, efficient, comfortable for the patient and significantly less costly. The idea is to design drug-loaded nanoassemblies that can be administered subcutaneously to enable the self-administration of all kinds of anticancer drugs, including irritant and vesicant drugs. Not only could this approach lead to more easy-to-handle chemotherapies, it could also boost the development of at-home cancer chemotherapy.


**Keywords:** Nanoparticles, polymer, progrugs, subcutaneous, cancer, metronomic chemotherapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Glucocorticoid-induced apoptosis and glucocorticoid resistance in lymphoid malignancies and autoimmune diseases (EUGIA)' (EUGIA).

assistant: **Innovation**

Glucocorticoid (GC) -induced apoptosis, although frequently not recognized, is a poorly understood phenomenon of major clinical significance: First, it is a central component in the treatment of lymphoid malignancies. Second, through its postulated effect upon immune repertoire generation, it might contribute to the pathogenesis of autoimmune diseases. We propose to investigate(a) the molecular basis of GC-induced apoptosis,(b ) mechanisms of the therapeutically important GC resistance, and ( c ) the role of these phenomena in autoimmune disease pathogenesis, thereby providing the basis for improved therapy of lymphoid malignancies and perhaps autoimmune disorders. The research will be performed by combining the expertise of clinical and basic scientists from 5 internationally renowned groups that will exploit functional genomics and other molecular techniques to analyse normal and malignant lymphocytes from afflicted patients, and from genetically modified and spontaneously autoimmune mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of the Cyclin-Dependent Kinase Inhibitor VS2-370 to Target HIV-associated Malignancies and to Purge Viral Reservoir' (THUNDER), addressing dissemination and exploitation.

assistant: **Impact**

ViroStatics, operating in the biotechnology industry, is developing the innovative drug VS2-370 that targets both HIV-associated cancer and its indirect cause, the viral infection. There is no similar drug, as HIV infection and associated malignancies are presently treated independently, without realizing that they are two sides of the same underlying pathogenetic problem. VS2-370 unique anti-CDK4/6/9 profile not only suppresses HIV, but also limits clonal expansion and induces apoptosis of infected cells, with the potential to purge the viral reservoir. Unlike with currently available antiretroviral therapy (ART) this could lead to a cure of HIV infection (or functional cure, that is to allow long periods of ART-free remission), mirroring the recent success of Hepatitis C cure, and it would similarly open a multi-billion Euro market opportunity. ViroStatics strategy is to develop VS2-370 through the well established pathway of oncology drugs, then to expand the indication to the HIV cure. VS2-370 has reached TRL6 and demonstrated anticancer activity in CDK4/6/9-dependent tumors in relevant in vitro and in vivo models, it has shown good exposure/tolerability profiles, and it has been produced in a GMP lot. After confirming the interest of a Pharma Customer with franchise in Oncology and/or HIV (Phase 1) we will file an Investigational New Drug application and carry out a First in Men (FIM) study through the extensive use of systems biology (Phase 2), thus significantly increasing the value of VS2-370 before out-licencing it to the Pharma Customer. The advantages for the final users (HIV-infected individuals with associated malignancies) will be: tumor- and ART-free remissions, quality of life improvement, decreased side effects associated with ART, cost savings for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ball grid array technologies for advanced telecom applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To develop a thin chip scale BGA package of medium ball count, with a grid pitch of 0.5 mm and a thickness of 1.4 mmTo fully characterise the developed BGA packages and make them available for reliability assessment, surface mounting on PCB and product validation.To develop suitable systems for the handling and inspection of thin BGA packages.To develop specific printed circuit board assembly techniques for the developed high density array packages.To perform a thorough evaluation of the related plastic packaging enhanced reliability problems through advanced test vehicles and characterisation methods.To qualify the developed thin chip scale BGA packages by product validation techniques using a selected telecom demonstrator circuit.To monitor the cost-effectiveness of the developed BGA packages.To issue guidelines for exploitation of the developed BGA packages in typical telecom system applications.In the BATEL project plastic ball grid array (BGA) packages, which are currently the best choice with respect to high pincount, high density, high performance and SMT capabilities, will be developed to meet a number of stringent telecom application requirements, such as the need for thinner packages with high pincounts and reduced grid pitches.Medium ballcount (+/- 200 balls) thin BGA's with a grid pitch down to 0.5 mm and a reduced profile down to 1.4 mm total thickness with chip scale potential will be developed. The developed BGA packages will be validated by means of an advanced GSM telecom demonstrator, processed in 0.35 um CMOS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Risk and resilience in adolescent decision-making' (DeMARRe) under Horizon Europe.

assistant: **Objectives**

Adolescents take more risks than adults do, contributing to the conventional framing of this period as one of great vulnerability. Surprisingly however, teenagers who engage in some degree of risk-taking exhibit more favorable psychosocial trajectories compared to those who avoid risks. This raises the intriguing possibility that taking risks during adolescence may, in fact, have enduring positive effects on adult behavior. The core objective of this proposal is to unravel the neural basis of how taking risks during adolescence can drive behavioral and neural circuit adaptations that promote resilience in adulthood. Risk-taking behavior can be studied in the context of decision making, where adolescents are more likely to explore risky choices, such as those with an uncertain outcome, than adults are. Strategy implementation under uncertainty conditions in adults is highly individualistic and is linked to activity in the dopamine system. As dopamine circuits develop during adolescence in a sex-specific manner, their maturation may contribute not only to the reduction in risk-taking observed between adolescence and adulthood, but also to sex differences in how risk modulates decision-making strategy. Finally, dopamine circuits may carry a neural imprint of the enduring positive effects on adult behavior. Here, I propose a concerted, multilevel experimental approach that builds from longitudinal behavioral and computational analyses of individualistic mouse decision-making across postnatal life in male and female mice. Embedding this core framework within sophisticated activity-mapping and network-manipulation techniques will allow me to dissect changes in dopaminergic networks during the transition from adolescence to adulthood that underlie decision-making strategy refi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Cracking the emotional code of music'.

assistant: **Innovation**

This project aims to ""crack"" the emotional code of music, i.e. to provide, for the first time, a precise characterization of what type of music signal is able to activate one emotion or another. Research into this problem so far has been mainly correlating indistinct emotional reactions to uncontrolled musical stimuli, with much technical sophistication but to little avail. Project CREAM builds on the PI's unique bi-disciplinary career spanning both computer science and cognitive neuroscience, to propose a radically novel approach: instead of using audio signal processing to simply observe musical stimuli a posteriori, we will harvest a series of recent developments in the field to build powerful new tools of experimental control, able to engineer musical stimuli that can activate specific emotional pathways (e.g. music manipulated to sound like expressive speech, or to sound like survival-relevant environmental sounds).By combining this creative use of new technologies with a well-concerted mix of methods from experimental psychology and cognitive neuroscience (incl. psychoacoustics, fNIRS brain imaging, EEG/ERP paradigms, intercultural studies, infant studies), project  CREAM will yield the first functional description of the neural and cognitive processes involved in the induction of emotions by music, and establish new avenues for interdisciplinary research between the life sciences and the information sciences.But most spectacularly, the fundamental breakthroughs brought by project CREAM will unlatch the therapeutic potential of musical emotions. Music will become a cognitive technology, with algorithms able to ""engineer"" it to mobilize one neuronal pathway or another, non-intrusively and non-pharmacologically. Within the proposed 5-year plan, support from the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'To investigate sustainable biological carrying capacities of key coastal zones important in the cultivation of marine bivalve molluscs' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This exploratory proposal outlines a programme designed to model key marine biomes, in coastal areas important for the cultivation of marine bivalve molluscs. The work will build upon recent work done in France.The novel aspect of the research is that parallel surveys will be carried out on several sites, which will allow a comparative nature to the data and, thus, a degree of cross referencing. The outcome of the research will be a data set which will offer shellfish growers better possibilities to predict the production capacity of a site and to manage their cultivation in a sustainable manner.The work could- also help provide parameters for better design of shellfish holding equipment and for its use on sites. The deliverables of the proposed research will help to maintain the production levels of existing areas, and to Increase production in newer areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'After the Ice: Postglacial hunter-gatherer lifeways' (POSTGLACIAL).

assistant: **Innovation**

The period of rapid global warming that took place at the end of the last Ice Age in NW Europe must have posed dramatic challenges for hunter-gatherers. This project aims to integrate high-resolution records of palaeoclimatic and palaeoenvironmental change with the remarkable and newly emerging archaeological record of postglacial sites around palaeo-Lake Flixton, (Yorkshire, UK).Star Carr was first excavated in the 1940/50s and has since become internationally famous in the archaeological world for its remarkable discoveries. The site had been situated on the edge of a lake and the peat which had subsequently formed allowed excellent preservation of rare organic remains, a wooden platform of “brushwood”, a wooden platform/trackway made of split and hewn timbers (the earliest evidence of systematic carpentry in Europe) and the discovery of the oldest known structure/house in Britain. Recent excavation reveal that the site is much larger than previously imagined, the excavated area to date constituting less than 5% of the total occupation area. In addition, a less well-known site on the nearby Flixton Island also has potential to provide important information on occupation and adaptation to climate change during the early phases of the postglacial.There are 4 reasons why this site merits extensive excavation now.   1, The site is under serious risk of disappearing forever due to peat desiccation and fluctuating water table with unprecedented levels of acidity (below pH 3.0) which have seriously affected the organic remains;   2, I have assembled a strong team of interdisciplinary researchers;   3, further excavation will significantly push forward the frontiers of knowledge;  4, pilot studies demonstrate that palaeoclimatic and environmental proxy data survives and can b