RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Insights in Eating Disorders Paving the Way for Innovative Treatments' (NIEDPWIT).

assistant: **Innovation**

My project aims at gathering new evidence to treat a major health concern: Eating disorders, including anorexia and bulimia nervosa and food bingeing leading to obesity. Following up on our parallel results showing an addictive component in these disorders and a dual role for serotonin (5-HT) in feeding, we postulate that the transition from the abusive consumption of food (food bingeing) towards excessive food deprivation (anorexia-like behavior), depends on the constitutive activity of the 5-HT-4 receptors (5-HTR4) and on changes from its inactive (R) towards its active state (R*) within the nucleus accumbens (NAc), a structure of the brain’s reward system.To demonstrate that the constitutive activity of 5-HTR4 in the NAc switches the direction of the addiction to food, I will modify the 5-HTR4 activity state using specific pharmacological treatments (from inverse agonist to overexpression) infused in the NAc of behaving brain-specific 5-HT deficient mice (Tph2-/-). Since my preliminary results show that Tph2-/- display feeding alterations (opposite in Tph2-/- and +/-), my first and second objectives will further characterize in detail their feeding pattern and its correlation with 5-HTR4 density in the NAc, body weight and fat storage. My third and fourth objectives test whether infusion of 5-HTR4 inverse agonist (decreased constitutive activity) and 5-HTR4 overexpression (increased constitutive activity) in the NAc induce respectively food bingeing and food refusal via the molecular cascade: cAMP-CART-FosB-ΔFosB. My experiments will show that controls of the “accumbal addiction pathway” by R and R* 5-HTR4 states are opposed and control the intake of food. Finally, I will realize a preclinical study and pave the way for the first clinical study using 5-HTR4 drugs to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Thematic network advanced manufacturing systems', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

TEAMS PROJECT OVERVIEW It is of vital importance for all European manufacturing industries to have access to a strong manufacturing industries. The parallel and complementary development of final products and their means of fabrication (e.g. car of tomorrow - manufacturing unit) are the key issues of transsectorial concurrent engineering. It will not be possible to substantially increase levels of employment and consolidate the revival in growth in the Union unless they are based on efficient, innovatory industry operating within an effective regulatory framework combined with a more labour-intensive development model. Steps must be taken to ensure that European Union remains an attractive site for production and investment, including investment from outside the Union. The TEAMS network allows, in relation to the IMT-programme to join the efforts in labour intensive sectors and to initiate innovations in order to maintain European manufacturing industries competitive. The 'real time' exchange of information on technological aspects of related projects will lead to much better R&D co-ordiantion and establish itself a network of very strategic importance. The included projects will increase the future exploitation of results and will be motivated to reach the settled targets due to the links to other similar and parallel conducted projects. The efficiency of the IMT-program will increase through deliverables on time and cost. It can be expected that the scope of special activities and projects will be widened towards a more global technological solution for the concerned area. EUROPEAN DIMENSION AND PARTNERSHIP The European machine tool sector consists of a large majority of small and medium sized enterprises. In front of international competition, the technological leade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanics of unsaturated soils for engineering' under Sixth Framework.

assistant: **Concept**

Unsaturated conditions (where soil pores are partly filled with and partly filled with air) occur widely both in natural soils and fills, where soil is used as a construction material. The hydro-mechanical behaviour of unsaturated soils is considerably more complex than that of saturated soils, and understanding within unsaturated soil mechanics lag considerably behind the state of-the-art in saturated soil mechanics. This is a significant limitation, because the hydro-mechanical behaviour of unsaturated soils is crucial to many applications in civil engineering (e.g. damage to structures founded on unsaturated soils and performance of flood embankments and earth dams), the nuclear industry (design of underground waste repositories), geohazards engineering (slope instabilities) and geo-environmental engineering (pollution migration and containment).The first objective of the proposed Network on Mechanics of Unsaturated Soils for Engineering is to generate an unrivalled database of suction-controlled experimental data on the engineering behaviour of different categories of unsaturated soils, including complex soils such as expansive clays and cemented soils. Experimental results will be used in the development and validation of improved constitutive models accounting for complex aspects of behaviour. Constitutive models will be implemented in FE programs and this will form part of a process of developing improved numerical capabilities for analysing coupled boundary value problems. The final objective is to demonstrate and validate the application of the constitutive and numerical modelling capabilities to a range of practical problems by simulating case histories and field trials. A particular feature of the Network is benchmarking of laboratory techniques, constitutive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Processing and Understanding of Early Remembering: origins and neural correlates of autobiographical memory beyond Infantile amneSia' under Horizon Europe.

assistant: **Concept**

PUERIS (“for children”) aims to provide the first multimodal neuroimaging investigation of autobiographical memory (AM) development during early childhood (ages 4, 6, 8), providing unprecedented insights into structural and functional neural underpinnings of AM ontogeny. AM, the ability to re-experience events of our life, is essential for maintaining personal identity across time, but remains limited in early childhood. Although the scarcity of AMs at this age is commonly attributed to immature neural networks involved in memory encoding, consolidation, and retrieval, no neuroimaging study has directly examined AM in children younger than 8. Building on my previous experience in functional magnetic resonance imaging (fMRI) in adults and the complementary expertise of my supervisors in the neural bases of AM and longitudinal neuroimaging of young children, PUERIS will: 1) Identify how the hippocampal–prefrontal network supports AM retrieval in children aged 4, 6, and 8 using structural and functional MRI; 2) Assess longitudinal neural changes underlying memory consolidation from one week to one year in 6-year-old children; 3) Capture the real-time encoding and retrieval of AMs in a naturalistic museum setting using portable functional near-infrared spectroscopy. The project will be implemented at Sapienza University of Rome (Beneficiary Institution) and the University of Maryland (Outgoing Phase Institution). The training provided by my supervisors, together with the scientific and transferable skills offered by the fellowship, will be essential to achieving the objectives of this project. Beyond advancing fundamental science, PUERIS will foster social and relational factors that support strategic memory behaviors, particularly the capacity to learn how to learn, throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Delox Air - Continuous air bio-decontamination compatible with human presence'.

assistant: **Concept**

We learned from the pandemic that air quality is essential for people’s health. Current technologies did not effectively manage infectious diseases propagated by aerosol suspensions of pathogens, leading to the need for social distancing and dramatically impacting the economy and people’s mental health. The challenge is not only cleaning the space but keeping people safe and free from microorganisms’ exposure without harming them with harsh chemicals. Delox AIR solution will change the paradigm of bio-decontamination of airborne pathogens in occupied spaces, a disruptive factor in the market. Based on our proprietary dryVHP, Delox AIR can kill microorganisms in the air with 99.99% efficacy, ensuring 100% human safety and consuming up to 20% less energy than current systems. Delox AIR can be readily integrated into any HVAC systems for continuous air purification.Delox AIR is part of the air purification market. We are targeting the commercial applications that capture the largest market (≈70% in 2021), accounting for €15.0 B by 2030. We will first target settings characterised by high occupancy density, presence of vulnerable individuals, and elevated risk of pathogen spread, such as nursing homes and hospitals, office spaces and educational and governmental buildings.Our business model (B2B) is based on indirect sales through distributors already working in the sector that will easily reach HVAC consultants/contractors (customer) designing and delivering a turnkey HVAC system for the end-user. We request EIC funding to complete the development of our system and validate it in three different types of closed environments. Our solution addresses the EIC Challenge of “Aerosol Decontamination for Pandemic Management”, satisfying the unmet need of facilitating social intera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of OTULIN and Met1-linked ubiquitin in immune signaling and host defense in vivo' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The immune system is essential for host defense against infections. Methionine1-linked ‘linear’ ubiquitin chains (Met1-Ub) have emerged as a crucial activator of NF-κB transcription factors, which are vital to immune responses. Recent findings suggest that defects in Met1-Ub signaling in humans can lead to severe immune dysfunction and cancer. Met1-Ub is generated by the linear ubiquitin chain assembly complex (LUBAC). Yet, how LUBAC and Met1-Ub signaling are regulated remains elusive. We recently discovered OTULIN, the only deubiquitinase known to specifically disassemble Met1-Ub. OTULIN antagonizes LUBAC and restricts Met1-Ub and NF-κB signaling in cell culture; however, the role of OTULIN and Met1-Ub in immune signaling and host defense in vivo is largely unknown. We have established novel mouse strains with cell type-specific deletion of OTULIN. I will use these mice to explore the in vivo function of OTULIN and Met1-Ub in the innate and adaptive immune responses, and to identify OTULIN substrates in primary cells using state-of-the-art mass spectrometry-based proteomics. I will study OTULIN’s role in immune homeostasis, in response to bacterial infection, and in mounting type-1 and type-2 adaptive immune responses by state-of-the-art methods of immunological analyses including comprehensive multiplex analyses of cytokines. Met1-Ub regulates the acute phase cytokines TNF and IL-6 and may thus control the development of type-1 versus type-2 immune responses. Hence, I will test OTULIN’s role in models of asthma, a disorder characterized by an imbalance between type-1 and type-2 responses. Subsequently, I will analyze immune signaling pathways in primary cells using mass spectrometry-based proteomics to identify OTULIN substrates in specific cell types. This will great
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AGILE 4.0: Towards cyber-physical collaborative aircraft development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A major challenge in the transport sector is to make economic growth compatible with sustainability and environmental constraints, while remaining competitive and innovative. The development of aeronautical products is a complex multidisciplinary process with requirements and constraints on the air transport system as a whole, the aircraft, and all the individual components to be produced. A major challenge impeding an efficient and cost-effective design processes is the integration of the various levels of the aeronautical supply chain. Therefore, the aeronautical industry needs to connect all the people, skills and technologies involved in its collaborative, multi-national and cross organizational processes, by means of a digital representation of production systems, supply chains, and seamless operations across diverse disciplines, during the entire life-cycle of the product. The high level objective of AGILE 4.0 is to bring significant reductions in aircraft development costs and time-to-market through the implementation of an integrated cyber-physical aeronautical supply chain, thereby increasing the competitiveness of the European aircraft industry, from integrators and high-tiers suppliers to SMEs, leading to innovative and more sustainable aircraft products.AGILE 4.0 targets the digital transformation of main main pillars of the aeronautical supply-chain: design, production and certification and manufacturing.The composition of the AGILE 4.0 consortium and capabilities available enable to address realistic development scenarios integrating multiple stakeholders and covering all the aspects of the development of complex aeronautical systems.AGILE 4.0 will provide the aircraft industry with a way to model, assess, and optimize complex systems addressing the entire
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microsensor for continuous arterial blood glucose monitoring' (GlucoSet).

assistant: **Innovation**

- Poor glucose control in critically ill patients leads to significant increases in costs, complication and mortality rates. Continuous monitoring of glucose will reduce costs of €2700 per patient and could save 58 000 lives in the EU every year.- GlucoSet has developed a disposable glucose sensor for monitoring glucose in the ICU. The sensor measures glucose by measuring sub-nanometer length changes in an advanced material that responds to the glucose level. The product is designed for mass-manufacturing at its core. The innovative fiber optic sensor is protected by granted patents and has freedom to operate. The sensor will be sold as a single-use device lasting 96h with a gross margin of over 90% at high volume. - The total addressable market (US and EU) is $1600 million per year. Willingness to pay has already been confirmed. The project has strong backing from key opinion leaders.- Unlike the competition, the sensor couples to the indwelling arterial catheter, which enables unsurpassed reliability and ease of use.- The SMEi phase 2 will take the project from working prototypes that have been tested in vivo, to a CE-marked device. We expect market entry in 2021 in the EU.- The company has a very strong team that has extensive experience with medical devices, scaling up production and raising and working with venture capital.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Theoretically-Sound Real-World Cryptography', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Novel technologies like Cloud Computing, Ubiquitous Computing, Big Data, Industry 4.0, and the Internetof Things do not only come with a huge demand for practical and efficient cryptosystems, but also with many novel attack surfaces. The security properties required from cryptographic building blocks for these innovative applications go beyond classical security goals.Modern theoretical cryptography has very successfully developed powerful techniques that enable the design and rigorous formal analysis of cryptosystems in theoretical security models. Now that these techniques are readily available, we have to take the next important step: the evolution of these techniques from idealized theoretical settings to the demands of real-world applications.The REWOCRYPT project will tackle this main research challenge at the intersection of theoretical and real-world cryptography. It will provide a solid foundation for the design and mathematically rigorous security analysis of the next generation of cryptosystems that provably meet real-world security requirements and can safely be used to realize secure communication in trustworthy services and products for a modern interconnected society.


**Keywords:** provable security, real-world cryptography, cryptographic protocols
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification and functional validation of novel enhancer sequences involved in pituitary gland development and pathology' under Horizon 2020.

assistant: **Concept**

There is a fundamental gap in understanding how the GPR101 gene regulates human growth in physiological and pathological conditions. Children’s growth is remarkably clinical relevant and is an important indicator of their health and general well-being. The specific objective of this proposal is to identify the molecular mechanisms underlying GPR101 overexpression in the pituitary tumors of children with GPR101 duplications causing X-linked acrogigantism (X-LAG).My central hypothesis is that GPR101 duplications disrupt the structure of the local chromatin, leading to the creation of a new chromatin domain where de novo enhancer-promoter interactions take place, causing abnormal GPR101 expression. This hypothesis will be tested by pursuing three specific aims:1.Elucidate the transcriptional regulation of GPR101 in normal and pathological conditions2.Identify and functionally characterize novel pituitary-specific enhancer sequences3.Investigate these regulatory sequences in patients with different pituitary pathologies.To achieve aim 1) I will perform an in vitro functional characterization of GPR101 promoter: promoter activity will be studied by luciferase-based reporter assays, by conducting a methylation analysis, and by determining its accessibility to transcription factors.To achieve aim 2) I will  validate my preliminary results showing the formation of a novel chromatin domain by 4C-Seq. Four putative enhancer sequences located within the duplicated GPR10 region and identified in silico will be functionally evaluated in vitro to establish their impact on transcriptional activity. To identify novel pituitary-specific enhancers, a whole-genome profile of enhancer-specific histone marks will be performed in normal and tumoral pituitary cells by ChIP-Seq.To achieve aim