RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Breeding improvement of Crassostrea gigas by nutritional and gametogenesis control'.

assistant: **Innovation**

Nutrition is among one of the major aspects, which can be at the origin of reproduction difficulties in oyster hatcheries. In commercial hatcheries, broodstock conditioning requires large quantities of phytoplankton and the choice of the algal species is generally dictated by its suitability for mass-production at a low cost under the environmental conditions of the hatchery rather than by its optimal nutritional value for the oyster. This empirical approach is at the origin of deficiencies in the algal diet for the broodstock, which may affect various aspects of reproduction, including spawning success, egg quality, and the growth rate, sensitivity to stress and pathogens of the larvae. This project aims at the improvement of broodstock management in oyster hatcheries through a better understanding of the relation between broodstock nutrition and quality of early life stages, with the following specific objectives:1. Document problems in current hatchery practice by comparison of nutritional aspects of reproduction under natural and artificial conditioning2. Identify critical nutrients for broodstock nutrition3. Define artificial diets to supplement these nutrients to live algae, taking into account the initial nutrient storage of broodstock4. Improve cost-efficiency of broodstock conditioningThe first year activities, being the sampling campaign in nature and two broodstock conditionings have been done. The histological and histochemical observations, biochemical analysis and the glycogen metabolism were evaluated and a comparison between the artificial broodstock conditioning and the natural conditioning were made. The effects of both conditions on the production parameters and on biochemical composition of the eggs and D-larvae were also evaluated. Formulation of di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Species-area relationship: new challenges for an old pattern' (SPAR).

assistant: **Innovation**

The main objective of the project is to identify factors shaping biodiversity as they pertain to the general species-area relationship patterns (SPARs), through the meta-analysis of the largest database (about 800-1000 data sets) so far used for this purpose. The meta-analysis will be conducted with state-of-the-art statistical analyses such as model selection criteria and structural equation modelling. Our goal is to successfully identify and cope with all the issues related to SPAR, in an effort towards a deeper understanding of this ecological regularity.The main questions addressed in the project are: Is there a general best-fit model for all types of SPAR? Is there a unique theoretical basis for the SPAR? What is the effect of scale and system configuration on the form of SPARs? Do the parameters of particular models have any biological and ecological meaning? Which is the role of other parameters, besides area, in shaping species diversity, and how do they interfere at various geographical scales? Is there a Small Island Effect, and what is the best method to detect it? How can we use the insights gained by SPAR analyses in conservation biology? Such a synthesis is of premium importance for a proper understanding and, thus, effective conservation and protection of biodiversity at all scales.The originality of the present proposal relies in the fact that for the first time the aspects related to the SPAR will be studied simultaneously, and not fragmentarily. The questions raised from the present proposal are part of the scientific core of disciplines related to the study of nature, such as biogeography, ecology, macro-ecology, evolutionary ecology, and conservation biology and conservation biogeography. Hence, the project fits within the thematic priority of Enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Delivering better fitness estimators for wildlife ecology and management and effective monitoring' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Fitness is a key concept in basic and applied ecology, and its traits are used to assess habitat quality and derive scientific knowledge used to design and implement management and conservation measures. Assessing fitness requires considering several traits and trade-offs, and long-term data sets with individual identification that are rarely available. As a result fitness proxies such as offspring production are often used as substitute but these do not consider variation in offspring survival and lifespan, which accounts for most variation in fitness is in long-lived species, like many endangered vertebrates.  Many studies, and decisions supported by them, involve unknown biases as consequence of the knowledge gap in the relationship between fitness and: the reliability of each proxy; trade-offs among different proxies; and among proxy/monitoring-effort combinations. This fellowship has secured access to several high-quality, long-term wildlife monitoring data sets  to gain insights in: the trade-offs and factors affecting individual fitness; the reliability of commonly used fitness proxies; and the assessment of bias and accuracy of short- medium-term monitoring programs focusing on different proxies. While working in leading European research groups and gaining excellent training ecological  concepts and theory and up-to-date analytical frameworks and methods, the fellow will : (1) provide high quality ecological knowledge on factors determinant of individual fitness and their trade-offs, and on factors explaining offspring recruitment; (2) assess of the reliability of commonly used fitness proxies; and (3) develop best practice and improvements for short-term monitoring protocols used in research, and management and conservation science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identifying novel classes of anti-HIV inhibitors' (NEWHIVTARGETS), addressing dissemination and exploitation.

assistant: **Impact**

Despite the success of highly active antiretrovirals to control HIV replication in infected patients, at least in countries that can afford these treatments, new drugs are still needed. Widely used drugs mainly target two viral enzymes, reverse transcrip tase and protease. However, about 20% of patients cannot tolerate antiviral cocktails in the short term, and long-term treatments are often associated with severe side effects. There is also increasing concern about the spreading of drug-resistant HIV va riants. Our aim is to identify lead compounds that could impact HIV through new mechanisms. Academia experts in virology and cellular biology have joined forces with antiviral-research specialists and pharmacologists, in order to perform anti-HIV high-t hroughput screening (HTS) assays. We have defined one unexploited viral target, for which there are no available inhibitors: The critical step of viral release from the cell. This novel target has been chosen because important recent discoveries have she d new light into the molecular mechanisms of virus budding, thereby rendering this critical step in HIV life cycle a feasible target for drug development. We are currently designing two assays allowing screening of libraries of chemicals. One is a cell-b ased assay and the other is a cell-free, protein/protein interaction assay. These assays do not require the use of infectious virus. Two libraries of 20,000 and 4,000 compounds, respectively, will be screened. We hope that these two complementary assays will allow the identification of hits or lead compounds, which could in a further step be improved by using a classical drug design approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Carabids as biocontrol agents for slugs in Oregon and Ireland - a novel and interdisciplinary approach to determine key malacophagous species and beneficial management options' (CaraSlug).

assistant: **Innovation**

One of the challenges identified under Horizon 2020 is the building of a sustainable agri-food industry. Agricultural pests such as slugs are major contributors to financial losses in the farming sector and the use of pesticides, which is currently the mainstay of control, is an unsustainable management option due to their toxicity to non-target species and consumers but also because of their cost and variable efficacy.  Biocontrol poses a more sustainable approach to pest control, but the only commercially available agent against slugs is the nematode Phasmarhabditis hermaphrodita which is ineffective against a number of key pest species, has a short shell life and is not permitted in countries outside of Europe (e.g. USA). CaraSlug aims to assess the potential of native carabid species as biocontrol agents against slug pests in Oregon and Ireland. For the first time, high-throughput sequencing and real-time PCR will be used in combination to analyse the gut contents of carabids collected over one year from vulnerable crops. Carabid species which are found to feed extensively on slugs and are abundant in crops at times when major slug damage occurs will be selected for feeding trials in the laboratory to further understand their feeding behaviour and biocontrol potential. By comparing the abundance of both pest and predator species and by determining the availability of alternative prey in differently managed crops e.g. with and without beetle banks over a year, management systems which provide optimum conditions for malacophagous carabid species will be identified. This project is interdisciplinary, combining ‘classic’ ecology and environmental management approaches with the latest advances in molecular biology and both the experienced researcher and the hosts will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cost and benefit of beta-lactam resistance in Streptococcus pneumoniae: interplay between the resistance determinants and the cell elongation/division components'.

assistant: **Objectives**

The widespread emergence of acquired resistance to antibiotics constitutes a serious threat to global public health. Among Gram-positive pathogens, Streptococcus pneumoniae (the pneumococcus) is a normal resident of the oral and nasal cavities but is also cause of otitis media and sinusitis as well as pneumonia, bacteremia and meningitis, particularly in young children and the elderly. Despite the availability of effective vaccines, S. pneumoniae remains an important clinical problem, also because of the increase of multi-drug resistant clinical isolates. S. pneumoniae is, indeed, listed by the WHO as one of the priority pathogens to drive research, discovery and development of new antibiotics. In S. pneumoniae, resistance to beta-lactam antibiotics represents a highly complex scenario, involving both target enzymes, the penicillin-binding proteins (PBPs), and non-PBP components, as the two-component system CiaRH. In clinical isolates, beta-lactam resistance is primarily mediated by the acquisition of multiple mutations in the transpeptidase domain of three of its six PBPs: PBP2x, PBP2b and PBP1a. These modified PBPs have reduced affinity for beta-lactams while leaving the enzyme function unaffected, thus conferring an advantage for the mutated strains in the presence of the antibiotics. However, PBPs are not only the beta-lactam target but are also essential enzymes involved the last stages of peptidoglycan biosynthesis, where they play specific roles in peripheral (side-wall) growth and cell division. Whereas the majority of studies so far concentrated solely on the effect of altered PBPs on resistance, little is known about the impact of the altered PBPs on PG biosynthesis, cell growth and division. Using a combination of genetic, biochemical, cytological and compara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Long-Term e-Health Evolution for Improving Diabetic Social and Behavioural Change Management' to be submitted under Seventh Framework.

assistant: **Abstract**

One of the key advances in recent healthcare technology innovations has been in the emerging mobile and network technologies for disease management, especially chronic diseases and diabetes in particular. The sharp increase of obesity linked with Type-1 diabetes in children and young population is becoming alarming in the UK and the European countries in general. Most of current projects and research studies that address self-management of diabetes and obesity focus on the functionality, technological and mobility issues but not on behavioural changes and acceptability challenges of these systems. To date, there is no study that addresses these major challenges and issues relating to the patients' adaptability (especially the younger population) with their health carers toward their self-diabetes management using emergent ICT technologies. This problem is more acute in diabetic and obese patients that do not adhere to their medications and in need of emotional support to maintain a more effective healthy behaviour (e.g. diet, exercise, medication compliance, etc.). This project will aim to research, design and develop a new and innovative platform and tools using a combination of long-term evolution wireless technologies linked with interactive robotic coaching technologies and intelligent decision support machines. Novel prediction and decision support algorithms based on reality health data mining, context awareness and artificial intelligence will be developed. These algorithms will then be used to process the information collected from the patients, via their in-home and mobile devices, and provide the necessary adaptable changes of the behavioural and medications preferences for the patients according to their individual needs. A prototype system which incorporates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Frequency-agile integrated photonic light sources across the visible and near-infrared spectrum' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Lasers are ubiquitous in science and technology, with applications ranging from optical communications and quantum technologies to metrology and sensing and to life sciences and medical diagnostics. However, most commercially used lasers are still based on legacy optical schemes. These devices are either bulky and expensive limiting product development, or lack the ability to quickly sweep or precisely control the laser wavelength, which is key to many applications. At the same time, the advent of advanced photonic integration platforms such as silicon photonics has opened new perspectives, realized only for exascale data centers in telecommunication wavelengths around 1310 and 1550 nm.AgiLight aims at establishing a new class of integrated lasers that can address the entire wavelength range from the blue (400 nm) to the infrared (2.7 µm). These devices rely on a hybrid integration platform that combines ultra-low-loss silicon nitride photonic circuits with advanced tuning actuators and with III-V gain elements, exploiting highly scalable assembly concepts based on 3D printing. The devices will offer high output powers (> 100 mW), down to Hz-level laser linewidths, and unprecedented frequency agility with nanosecond response times and wideband tunability. Comprising leading European research groups and high-tech start-ups as well as a major industrial player, AgiLight will translate ground-breaking research to rapid technology uptake and tailor laser systems for atomic and molecular physics and optics, distance ranging and sensing using the expertise of end-users. The project covers the theoretical and nanofabrication foundations of the envisaged light sources as well as their implementation and functional demonstration in highly relevant research applications throughou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Data-driven Approach to Microstructural Imaging' to be submitted under Horizon Europe.

assistant: **Abstract**

The ability to study tissue microstructure in vivo and completely noninvasively using magnetic resonance imaging (MRI) has the potential to radically change how we detect, monitor, and treat diseases, in particular the many neurodegenerative diseases that affect our world’s aging population. Unfortunately, the MRI signal is a very indirect measure of microstructure, and the variety of contributing factors complicates a one-to-one association between the MRI measurements and the biological substrate. As a result, microstructural mapping is still a poorly understood and challenging inverse problem that often yields inconsistent and contradictory outcomes. In ADAMI, I will take the next leap in microstructure imaging by approaching the problem in a completely data-driven fashion as opposed to the state-of-the-art that is model-driven. This paradigm shift will enable me to turn the MRI scanner into a powerful in vivo microscope that can provide reliable information about tissue microstructure that closely matches the underlying cellular composition. Rather than relying only on a single source of contrast, I will exploit the versatility of MRI and use multiple, independent contrast mechanisms that will provide the necessary information to distinguish reliably between microscopic substrates. Rather than relying on preconceived models, I will use machine learning to learn the appropriate models directly from the data. Rather than performing a posteriori histological validation of these new microstructural models, I will acquire a priori histological data to directly inform this learning process, guaranteeing, for the first time, a close match between microstructural readouts obtained from MRI and invasive histology. Through these innovations, ADAMI will advance the field of me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SOCIAL INNOVATION IN ENERGY TRANSITIONS: Co-creating a rich understanding of the diversity, processes, contributions, success and future potentials of social innovation in the energy sector' (SONNET).

assistant: **Innovation**

SONNET aims to create an inter- and transdisciplinary understanding of the diversity and processes of social innovations in the energy sector (SIE). It assesses - critically and reflexively- the success, contributions and future potential of SIE towards sustainable energy transitions in Europe. SONNET investigates how, to what extent and under which enabling conditions diverse types of SIE may result in new breakthroughs or successfully help to overcome transition barriers; such as limited citizen engagement or slow adoption of new technologies. SONNET’s empirical research is informed by a novel conceptual framework combining insights from sustainability transitions, energy studies and social innovation literatures. It bridges qualitative and quantitative methodological approaches in an innovative multi-method research design. Across 30 qualitative in-depth case studies situated in six European countries, SONNET investigates the diversity, processes, success and contributions of SIE. Given its focus on urban areas as major hubs for SIE, SONNET conducts six transdisciplinary SIE city labs to experiment with new forms of SIE and learn about how multiple actors can harness the potential of SIE. In addition, based on three large-scale representative citizen surveys, SONNET assesses the future potential of SIE and derives implications for reconfiguring existing and developing new business models. SONNET synthesizes its findings in an integrated knowledge framework for a socio-economic, socio-cultural (incl. gender) and socio-political understanding of enabling and impeding conditions for SIE and SIE contributions when working towards accelerating sustainable energy transitions in Europe. Through a cutting edge co-creation, dissemination and exploitation strategy, SONNET ensu