RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Changing Multilateralism: The EU as a Global-regional Actor in Security and Peace'.

assistant: **Concept**

GRASP aims to contribute to the analysis and articulation of the current and future role of the EU as a global and regional actor in multilateral security governance, in a context of challenged multilateralism, where the EU aims for “effective multilateralism”. This project will examine the notion and practice of multilateralism in order to provide the required theoretical background for assessing the linkages between the EU’s current security activities with multi-polarism, international law, regional integration processes and the United Nations system. The project’s work plan will consist of the following components: (i) conceptual integrated analyses of the evolving concepts of multilateralism and security and the EU’s role as a security actor; (ii) case-studies of the EU’s approach to a number of specific security issues (regional conflict; terrorism; WMD proliferation; migration; energy and climate change; and severe violations to human rights); (iii) a transversal comparative analysis applying and integrating the case study findings; and lastly, (iv) a foresight study, building off the project’s findings that will detail scenarios for future EU policy towards external security relations and multilateral approaches to threats and challenges. The research will be policy-oriented and include a strong interactive dimension, in order to assure ongoing feedback from the target-public. The work will be undertaken by a consortium of European research centers that have already collaborated on these issues (FP6). This group is enlarged by the inclusion of a number of institutes from outside the EU (Israel, Canada, South Africa and China) that will bring in further expertise on specific security issues in addition to important regional perceptions, necessary to avoiding a na
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chronic inflammation and cardiovascular risk' to be submitted under Horizon 2020.

assistant: **Abstract**

Cardiovascular disease is the leading cause of death and illness globally. Preventive therapies can avoid or delay the occurrence of cardiovascular events, provided that one can identify individuals at risk and intervene before problems manifest. Recent scientific developments have established that inflammation has a prominent role in the development of cardiovascular diseases; but routine screening of inflammatory markers to assess cardiovascular risk in the general population is currently unfeasible. It is known however that certain diseases cause high and chronic inflammation, and patients affected by these conditions may be at increased risk of cardiovascular events. Yet, studies so far have been limited by the relatively modest absolute numbers of patients affected, so that for many of these conditions evidence is insufficient to guide clinical decisions. The aim of this research proposal is to investigate the associations between a range of chronic inflammatory conditions and different types of cardiovascular disorders, by using one of the largest longitudinal healthcare datasets available for research purposes in the world. The study design leverages the potential of ‘big data’ to explore complex disease associations through a unique combination of skills – my own knowledge of epidemiology and experience with the studied data set; my host supervisor’s expertise in statistical models best suited for the analysis of longitudinal data; and interdisciplinary clinical expertise through an international network of collaborations.A better understanding of cardiovascular risks associated with chronic inflammatory conditions may help guidelines and clinicians to focus on patients for which screening and treatments are more likely to have an effect, and improve the prevent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Parameterization of computational domains for isogeometric analysis' (PARADISE) targeting Seventh Framework.

assistant: **Abstract**

Isogeometric analysis (IA), which was introduced in 2005 by Tom Hughes et al., is a novel technique for numerical simulation which uses the same spaces of functions for the representation of the geometry and for the numerical simulation. It has the potential of closing the gap between numerical simulation and computer aided design, which is caused by the different representations of geometry (piecewise linear vs. rational splines = NURBS). This gap is currently a bottleneck in the design process, since the design and the numerical simulation phase cannot be connected in a seamless fashion, but only through time-consuming conversion processes.The application of IA leads to new challenging problems for geometric design, which are related to the representation of computational domains by NURBS parameterizations. The project will address some of them.More precisely, it will discuss computational methods for generating NURBS parameterizations for several classes of computational domains, such as CSG models, general CAD models, and domains obtained from medical data. It will also analyze the quality of these parameterizations with respect to the distribution of singularities and with respect to the distortion which is introduced by the parameterization. Additional points of interest are the construction of locally refinable spaces of test functions for IA, which are compatible with NURBS parameterizations and support both h-refinement (knot insertion) and p-refinement (degree elevation), domain decomposition techniques and design optimization.These three topics will be analyzed in close connection to related applications to numerical optimization and to shape optimization. The execution of the project requires the combination of knowledge available at the host institution wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'HERMES – High Exponential Rise in Miniaturized cantilever-like Sensing'.

assistant: **Concept**

Miniaturized cantilever–like sensors have evolved rapidly.  However, when it comes to major breakthroughs in both fundamental studies as well as commercial applications these sensors face severe challenges: i) reliability – often only one or two measurements are performed for the same conditions due to very slow data generation and the results are rarely confirmed by orthogonal sensing technologies, ii) sensitivity – in many applications the need is now for ultra-low sensitivities, iii) reproducibility – very few results have been reported on reproducibility of these sensors iv)throughput –extremely slow and tedious read-out technologies. In order to take a great leap forward in cantilever-like sensing I suggest a new generation of simplified and optimized cantilever-like sensing structures implemented in a DVD based platform which will specifically address these issues.My overall hypothesis is that the true potential of these exciting sensors can only be released when using a simple and reliable read-out system that allows us to focus on the mechanical performance of the sensors. Thus we will keep the sensors as simple as possible. The DVD readout makes it possible to generate large amount of data and to focus on mechanics and the interplay between mechanics, optics and electrochemistry. It will be a technological challenge to realize a robust and reliable DVD  platform, that facilitates optical read-out as well as actuation. The DVD platform will enable a fast and iterative development of hybrid cantilever-like systems which draw upon our more than 10 years experience in the field. These sensors will be realised using Si and polymer based cleanroom fabrication. Focus is on design, fabrication, characterization and applications of cantilever-like sensors and on DVD ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Yoctosecond imaging of QCD collectivity using jet observables'.

assistant: **Objectives**

QCD is the only sector of the Standard Model where the exploration of the first levels of complexity, built from fundamental interactions at the quantum level, is experimentally feasible. An outstanding example is the thermalised state of QCD matter formed when heavy atomic nuclei are smashed in particle colliders. Systematic experimental studies, carried out in the last two decades, overwhelmingly support the picture of a deconfined state of matter, which behaves as a nearly perfect fluid, formed in a very short time, less than 5 yoctoseconds. The mechanism that so efficiently brings the initial out-of-equilibrium state into a thermalised system is, however, largely unknown. Most surprisingly, LHC experiments have found that collisions of small systems, i.e. proton-proton or proton-lead, seem to indicate the presence of a tiny drop of this fluid in events with a large number of produced particles. These systems have sizes of 1 fm or less, or time-scales of less than 3 ys. To add to the puzzle, jet quenching, the modifications of jet properties due to interactions with the medium, has not been observed in these small systems, while jet quenching and thermalisation are expected to be controlled by the same dynamics.  Present experimental tools have limited sensitivity to the actual process of thermalisation. To solve these long-standing questions we propose, as a completely novel strategy, using jet observables to directly access the first yoctoseconds of the collision. This strategy needs developments well beyond the state-of-the-art in three subjects: i) novel theoretical descriptions of the initial stages of the collision — the first 5 ys; ii) jet quenching theory for yoctosecond precision, with new techniques to couple the jet to the surrounding matter and novel part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A novel marine pharmaceutical with unique mechanism of action for t he treatment of cancer' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives :The primary objective of this demonstration project is to verify the anticancer clinical activity of Ecteinascidin-743 (ET-743), a new marine entity harbouring a novel mechanism of action. Clinical activity will be verified against six solid malignant tumor types for which available therapies have no or limited effects.The selected tumor types are melanoma, lung cancer, ovarian cancer, breast cancer, renal cancer and prostate cancer. The clinical plan has been implemented on the basis of results emerging from appropriate experimental models which show ET-743 to be highly potent with a unique profile of activity when compared to standard anticancer agents. Mechanism studies have identified ET-743 as a novel DNA interacting agent, acting at the minor groove with specificity for guanine rich regions. It is therefore expected that this novel mechanism of action may be translated into a novel spectrum of anticancer activity. The studies will be conducted under Good Clinical Practice guidelines with separate clinical protocols for each tumor type. The number of patients to be entered in the studies is defined by the statistical requirements to verify the tumor response rate. The project milestones are based on the statistical analysis for each tumor type. On verification of activity in the early studies, further confirmatory studies are carried out. The clinical studies will involve three partners which provide a balance between the pharmaceutical industry and innovative clinical research units. The partners are structured to provide European wide involvement which ensures rapid evaluation while retaining strict logistical management to ensure the results are to regulatory standards. The partnership also ensures that the use of the compound is exposed to prominent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new approach for genic SNP discovery in polyploid bread wheat' (COMPSNPS) targeting Sixth Framework.

assistant: **Abstract**

Single nucleotide polymorphisms have become the 'industry standard' marker type in mammalian and human genetics, and will be important for a biotechnology-oriented approach to genotype improvement and redesign. The project aims to develop a generic platform for genic SNP discovery in the major temperate cereal crop species, bread wheat. Polyploidy compromises the standard approach for sequence variation detection in specific amplicons, and to address this, a strategy using SSCP separation of complex amplicons to develop homoeologue-specific PCR assays is proposed. The proposal will exploit the rice genome sequence and the existence of synteny among the grass genomes to drive primer design, and this is complemented with a SNP discovery platform based on heteroduplex identification using dHPLC technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improved coordination of national and European bioeconomy research and innovation programmes in the ERA through strengthened SCAR Working Groups' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Standing Committee on Agricultural Research (SCAR) is a long-standing committee of EU Member States and Associated Countries presided over by the European Commission. It has become a respected source of advice on European agricultural and wider bioeconomy research and has been a catalyst for the coordination of national research and innovation (R&I) programmes. It is supported in these strategic functions by SCAR Working Groups (WGs), including a Foresight Group, which provide domain-specific expert advice and input. RefreSCAR will strengthen the strategic functioning and capacities of SCAR WGs in order to facilitate the improved coordination of national and European bioeconomy R&I programmes. Through a toolkit of measures, RefreSCAR will provide robust scientific support to SCAR WGs through regular portfolio analysis of projects, expert studies and support for the SCAR Foresight process. Combined with practical administrative support, this will enable a better structured organisation, facilitation and reporting of SCAR WG activities in themes of relevance for Horizon Europe, the Common Agricultural Policy, European Green Deal, Digital Europe and the Farm to Fork and Biodiversity Strategies. In order to boost the participation of under-represented countries in SCAR WGs, a SCAR-Engage Programme will be developed involving tailored action plans, financial and peer-to-peer support, networking and knowledge exchange. Targeted support for communication and dissemination will immerse a broad audience of stakeholders in the activities of the WGs. Furthermore, RefreSCAR will cultivate connections between SCAR WGs, key actors in EU policy, practitioners and relevant EU and international initiatives through dedicated fora, helping to build a bridge between R&I, policy and pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'UPM - Marie Curie International Mobility Programme' under Seventh Framework.

assistant: **Concept**

The dramatic evolution in technology development where science-driven engineering is taking more and more importance is motivating a deep change in the mentality of engineering schools. The role of multidisciplinarity, and the need to increase staff mobility is becoming another driving force in the composition of research groups. UPM is aware of the huge importance that human resources will have for its future. Then, as a consequence, UPM has created a set of internal programmes to recruit researchers and to promote mobility in order to facilitate this evolution and this proposal is to complement its existing programme. UNITE have the following four general objectives: 1. To complement the policy measures implemented by UPM to facilitate the recruitment and mobility of experienced researchers 2. To increase the internationalization of researchers of the UPM by facilitating their mobility to/from other countries 3. To open new permanent positions to senior researchers from other countries 4. To establish a professional research career in UPM offering tenure-track positions for research and technological staff, based on COFUND and on the draft of the Spanish “Law of Science”, and linked to the labour market of European researchers. To aid the fulfillment of the objectives proposed above all types of mobility offered by COFUND has been included in the UNITE proposal. The schemes are foreseen to incorporate a maximum of 19 experienced researchers and will be advertised in three separate calls as follows: 1. Call 1: 3 senior researchers: incoming - re-integration fellowships 2. Call 2: 3 experienced researchers: outgoing fellowships 3. Call 3: 13 experienced researchers: incoming - re-integration fellowships
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of genetic factors which determine host specificity in the wheat-powdery mildew pathosystem' in the context of a Horizon 2020 call.

assistant: **Objectives**

Powdery mildew caused by the fungus Blumeria graminis f.sp. tritici (Bgt) is a devastating disease of wheat with poorly understood plant-pathogen interactions. Sequencing of the Bgt genome indicated that hundreds of effector proteins are manipulating the plant cell and determining the virulence spectrum of a particular mildew strain. Bgt rapidly adapted to the introduction of the new host species bread wheat, which arose only 8,000-10,000 years ago. Bgt has since evolved into strains which are specialized on domesticated wheat and such which grow on wild wheat species. Genes responsible for the host specificity in an obliagte biotrophic fungus are unknown. To study the mechanisms of adaptive evolution in the highly repetitive Bgt genome, whole genome re-sequencing data of a mapping population derived from a cross between Bgt isolates that differ in their host specialization will be used to determine the frequency and distribution of recombination events and precise mapping of recombination breakpoints. Of particular interest is to study the impact of recombination on the clusters of effector genes. The factors that determine host specificity will be genetically mapped. This will allow conclusions on which and how many genes were responsible for the Bgt adaptation to the bread wheat host. The proposed research is taking a multi-disciplinary approach combining whole genome re-sequencing, classical genetics, molecular plant pathology and comparative genomics. This study will broaden our understanding of Bgt genome evolution and will help to design rational strategies for sustainable powdery mildew disease management.


**Keywords:** Blumeria graminis tritici,  wheat,  recombination, effector gene,  host specialization ,  plant-pathogen interactions,  adaptive evolution, po