RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Form for function: regulation of  bundle sheath cell architecture for C4 photosynthesis' (CELL4), addressing dissemination and exploitation.

assistant: **Impact**

PROPOSAL SUMMARY The architecture of specialised cell types intricately aligns with cell function. A prime example is the bundle sheath (BS) cells of plants conducting C4 photosynthesis, in which CO2 is concentrated. This concentration mechanism increases photosynthetic efficiency by up to 50% compared to plants that use the more common C3 photosynthetic pathway. BS cells of C4 plants have two key adaptations: increased connectivity with adjacent mesophyll cells via numerous plasmodesmata that facilitate metabolite exchange for building CO2 concentration, and an increased number of organelles which are uniquely positioned at one side of the cell. Despite the proposed functional importance of these traits, it is not understood how they arise during leaf development.In this project, I aim to elucidate mechanisms governing BS cell architecture. I recently discovered that the polar localisation of plasmodesmata and organelles in BS cells occurs early in leaf development following light exposure in multiple C4 plants. I will use 3D electron microscopy to study BS cell development at high resolution in the C4 grass sorghum and mass spectrometry imaging to map key C4 metabolites, linking structure to metabolic function. I will then investigate molecular mechanisms involved in the development of both traits using mutants that are disrupted in components known to influence plasmodesmata development and organelle positioning in C3 species. I will identify additional components by looking for interaction partners of these components in C4 BS cells. In mutants showing defects in either trait, I will study the impact on metabolite gradients and photosynthetic efficiency, and will explore interdependency between the two polar traits. Overall, my project will reveal mechanisms essenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Study of the role and the function of a new g protein subunit regulated pi3 kinase'.

assistant: **Objectives**

Research objectives and content My research project will be to determine the different functional domains of a new PhosphatidylInositol 3-kinase (PI3kinase). My host laboratory has isolated and cloned a new PI3kinase that is activated by heterotrimeric G-protein By subunits. This enzyme is composed of a subunit (p120) that possesses a lipid kinase-catalytic activity and a p101 subunit that seems to have a regulatory role. The aim of my project will be to understand the role of p101 in the activation of the PI3 kinase by G-proteins. First, I will determine the interaction domains between these two subunits and the role of this complex in the activity of the enzyme. Then, I will study the interaction with other signalling proteins. Secondly, I will study the physiologic role of this heterodimer in different cell types, such as U937 cells and Sf9 cells. Training content (objective, benefit and expected impact) This work will involved training in Molecular Biology and lipids Biochemistry. All these techniques will be an important benefit and very useful for the development of my career as a researcher in France for INSERM or CNRS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Implementation of Market Oriented Product Innovation in Danish Small and Medium Enterprises' (MARKPRO) targeting Fourth Framework.

assistant: **Abstract**

The overall objective of project PRO 050 (MARKPRO) is to assist Danish SMEs to become more innovative and thus more competitive through the implementation of a series of Innovation Management Techniques. Responsible for the implementation of these techniques will be 11 IMT consultants who, following a selection procedure, will participate in a 3 day seminar to be trained in market orientation and product development methodologies.The consultants will carry out 22 assignments in Danish SMEs spread over 4 regions (North and South Jutland, Funen and Zealand). The assignment work is in modular form and dependent upon the enterprises situation, entails diagnosis, specific analysis and follow-up. The selected methodologies to be promoted are as follows:- Measurement of market orientationA proprietory tool called MAPPMO which is a supported by a software tool and measures the attitude and behaviour in terms of market orientation of an enterprise- ADVIA which is a strategic marketing software package- Select a tool which helps enterprises select appropriate product projects for commercialisation- QFD - Quality Function Deployment- Stage / Gate System - a project management tool for developing new products- Value analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanisms of homeostatic plasticity in the intact mouse visual cortex'.

assistant: **Concept**

Changes in input lead to changes of synaptic circuits in the brain via a combination of synapse specific Hebbian plasticity and cell-wide homeostatic plasticity. While Hebbian plasticity has been well studied, there are still a number of outstanding fundamental questions related to homeostatic plasticity. We have previously developed a paradigm that allows us to monitor changes to multiple homeostatic mechanisms in the intact mouse visual cortex following sensory deprivation. We will use this paradigm together with chronic two-photon imaging of synaptic structures and function, via genetically encoded calcium indicators in awake behaving animals.  These techniques allow us to measure the structure and function from the same synapses and cells over a period of weeks to months, both before and after sensory deprivation. In the work proposed here, we will investigate two basic principles of homeostatic plasticity: 1) the spatial scale at which homeostatic mechanisms occur – is it at the level of individual dendrites or are all changes implemented cell-wide? and 2) the relationship between homeostatic plasticity and the degree of changing activity levels in cells and networks of cells – is the degree of resulting homeostatic plasticity dependent on the level of deprivation? If so, can changes in dendritic activity, cellular activity or network activity drive these changes?  We will investigate these questions for both excitatory and inhibitory neurons in the intact mouse visual cortex for two forms of homeostatic plasticity – synaptic scaling and the balance between excitation and inhibition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developing strategies for regulating and managing water resources and demand in water deficient regions' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Objective of the project is to develop and evaluate alternative strategies for regulating and managing water resources development of the Southern European water deficient regions. Methodology, tools, guidelines and protocols of implementation will be developed that enable decision makers to delineate and assess a wider range of integrated water management strategies. Expected results include the evaluation of existing water management situation in Southern Europe through a systematic typology of water management problematique, the development of a methodology for evaluating water management scenarios, the development of water resources allocation scenarios and water cost recovery strategies, the formulation of guidelines and protocols for integrated water management and training decision makers on implementing multi-objective water management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unlocking vital mysteries in respiratory biomechanics' (BREATHE).

assistant: **Concept**

While the human lung is undoubtedly an essential organ, and respiratory diseases are leading causes of death and disability in the world, there still exist a lot of mysteries wrt vital processes. The main reason for this is the complete lack of measurement methods or medical imaging techniques that would allow to study dynamic processes in essential parts of a living human lung. While this would be a perfect setup for computational modeling, existing models suffer from severe constraints disabling them to unveil those essential secrets. This project aims to build on a number of most promising recent advances in modeling and high-performance simulation to present the first comprehensive computational model of the respiratory system. For this purpose, it builds upon a recent exascale-ready incompressible flow solver, toughen it up for lung specific challenges and enrich it with multiphysics capabilities to capture tissue interaction and gas transport. Parts of the respiratory zone will be represented by multiphase poroelastic media and novel pleural boundary conditions will be developed. The coupled pulmonary circulation will be included and represented by an embedded reduced dimensional network and additional phases. In order to appropriately individualize the model and also being able to adapt it during disease progression, a novel physics-based probabilistic learning approach will be developed. This will allow to use most of the very diverse and scarce data in clinical settings. Finally, special models will be developed to bridge to the micro scale. The models developed and studied here will provide unprecedented insights for biomedical scientists, and practitioners at the same time, and will help to substantially reduce elaborate animal and multicenter studies. This w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LEADERSHIP IN ENABLING AND INDUSTRIAL TECHNOLOGIESfor EUROPEAN SOCIETAL CHALLENGES 2014(Nanotechnologies and Advanced Materials, Manufacturing and Processing)' to be submitted under Seventh Framework.

assistant: **Abstract**

Europe is currently facing historical challenges that will determine its future role in world’s economy  and in the definition of the socio-political equilibrium of the next decades when both industrial and social policies will be determinants to allow a sustainable European renaissance.The EU 2020 Strategy highlights those short term and long term actions able to respond to the challenges Europe is willing to master. Under these premises, CNR, APRE and ASTER will organize the “LEADERSHIP IN ENABLING AND INDUSTRIAL TECHNOLOGIES” 2014 CONFERENCE (LEIT 2014) under the Italian Presidency of the European Union with the endorsement of the Italian Ministry for Research and Education (MIUR).The objective of the LEIT 2014 CONFERENCE” will be:-    to discuss the European strategy, vision and mission for research and innovation in Industrial Technologies, within the frame of Horizon 2020.-    to highlight the connection between Industrial leadership and Societal Challenges-    to support networking among stakeholders, also outside the “NMP community”-    to stimulate future appropriate political initiativesThe LEIT 2014 CONFERENCE will be organised in Bologna from September 29th to October 1st 2014 and will debate on how to efficiently exploit the results of research and technological development in the field of nanotechnologies and advanced materials, manufacturing and processing (NMP themes) in order to transform these results into products, processes, systems and business models able to face the societal challenges, through  the support of excellent science and key enabling technologies.Within this aim, the conference will provide different points of view to investigate the Research and Innovation contribution of enabling and industrial technologies, fostering both social lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Statistical methods for 3D imaging mass spectrometry in proteomics and metabolomics' in the context of a Seventh Framework call.

assistant: **Objectives**

Since biology is by and large a 3-dimensional phenomenon, 3D imaging has a significant impact on many challenges in life sciences. 3D matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) is an emerging label-free 3D imaging technology with high potential in proteomics and metabolomics. 3D MALDI-IMS is based on 2D MALDI-IMS, which in the last years has proven its value in metabolomics, glycomics, lipidomics, peptidomics, and proteomics. However, 3D MALDI-IMS cannot tap its full potential due to the lack of computational methods for processing large and complex 3D IMS data. Our main goal is to realise 3D label-free proteomics and metabolomics by providing new statistical methods for the reproducible collection of 3D MALDI-IMS data, and for un- and supervised statistical analysis and interpretation of this data. We will validate our methods in diabetes research, surgical metabolomics, and natural products research. To reach our global goal, we will develop methodologies for reproducible collection of 3D MALDI-IMS data, develop a statistical simulator of MALDI-IMS data and evaluation strategies for statistical methods, develop preprocessing, unsupervised, and supervised methods of statistical analysis of 3D MALDI-IMS data, evaluate the developed methods on simulated and real-life proteomics and metabolomics data, and implement them using efficient graphic processing unit (GPU) architecture. This project is of high importance for research-intensive SME partners, Denator and SagivTech, since it would create a new market segment for them. Expertise of partners in biomedicine and their strong connections to clinical partners ensure adoption of the new methods into clinical practice. The developed methods and protocols can be potentially used in an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training' (KHCCBIO) targeting Seventh Framework.

assistant: **Abstract**

The King Hussein Cancer Center (KHCC) in Jordan, a highly accredited hospital, treats over 3,500 new adult and paediatric cancer patients annually from Jordan and its neighbouring countries. KHCC wishes to maintain its pioneering position in cancer detection and treatment and plans to establish a state-of-the-art biospecimen repository to store and archive tissue samples for use in cancer research with the support and experience of experts in biobanking and quality management from Trinity College Dublin and two European SMEs.The KHCCBIO bank will collect, process, extract, store high-quality, clinically annotated biospecimens from consented patients and distribute them to researchers worldwide. It will be established using current international guidelines, best practices and will incorporate the highest level of Quality Management System (QMS) based on ISO standards & the EU’s Tissue & Cells Directives.European partners will deliver training and support to KHCC and provide a proven solution, based on existing licensed technology & know-how. Instruction and training will be given in FP7 project management, implementation of Quality Management Systems, genetics of thoracic cancer, creation of a Europe-wide lung cancer biobank (EUELC), standard operating procedures for the procurement, processing, storage and distribution of human tissues & cells, expert guidance in ethics, data protection & confidentiality, computer systems implementation & validation and an introduction to an international network of oncology specialists to interact with and share knowledge with.Today, the vast majority of the millions of biospecimens in collections around the world are not suitable for making the type of direct comparisons that modern cancer biology research demands. The KHCCBIO bank wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Probing the nature of heterogeneous electron-transfer at the sensitisercolloidal semiconductor interface in tio2 based photoelectrochemical cells' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content It is now possible to fabricate electrochemical photovoltaic devices based upon dye sensitised nanocrystalline titanium dioxide films. These novel solar cells are already in industrial production, offering the potential for a five fold drop in production costs compared to conventional silicon PV cells. The function of these composite material devices is based upon an interfacial electron transfer reaction from an optically excited dye molecule into the titanium dioxide, thus sensitising this wide bandgap semiconductor to visible light. However, lack of scientific knowledge about the electronic properties of this interface is limiting further technological development. For example, up to a two fold increase in device efficiency could be achieved by the use of sensitiser dyes with increased long wavelength absorption, but extensive empirical trials have as yet failed to identify any suitable alternative dyes. We therefore propose to conduct a systematic study of the dye sensitisation process in these devices, in order to identify those characteristics of the dye / semiconductor interface which are essential for efficient device function, and leading to the development of higher efficiency electrochemical solar cells. The sensitisation reaction occurs on ultrafast timescales, and therefore a key component of this project will be the application of ultrafast spectroscopic techniques to the elucidation of this problem. Training content (objective, benefit and expected impact) acquiring a working knowledge of state-of-the-art ultrafast spectroscopy theoretical and experimental understanding of photoelectrochemistry development of independent research skills Links with industry / industrial relevance (22) Several European companies have expresse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intelligent Knowledge Assets Sharing and Trading' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The INKASS project addresses the area that is at the intersection of Knowledge Management and Electronic Commerce. This area refers to the trade of explicit and implicit knowledge for specific needs at an inter-organisational level, addressing the opportunities and risks found in the purchase and selling of knowledge at the business-to-business environment. The INKASS project aims at the development of an Internet-based marketplace of knowledge assets that will be targeted at European SMEs and their knowledge needs in the areas of professional services for business management and engineering. The project result will be a total solution for knowledge trading, which integrates both technological and non-technical elements (business models, roles, processes and revenue models).