RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Large area transparent thin film thermoelectric devices for smart window and flexible applications' (TransFlexTeg).

assistant: **Concept**

The main objective is to develop an innovative large area distributed sensor network integrating transparent thin film thermoelectric devices and sensors for multifunctional smart windows and flexible high impact volume applications. Different breakthrough concepts are proposed: 1) large area high performance transparent thermoelectric thin films deposited on flexible substrates for thermal energy harvesting; 2) low cost high throughput thin film thermal sensors for thermal mapping and gesture sensing; 3) flexible smart windows and walls with energy harvesting, environmental sensing and wireless communication functionalities.The developed technology aims to demonstrate the functionalities of a smart window able to measure air quality and environmental parameters such as temperature, sun radiation and humidity. The data is automatically collected and can be utilized for controlling heating, cooling and ventilation systems of indoors. Active radio interface enables long range communication and long term data collection with WiFi or a similar base station. The proposed concept of smart windows replaces several conventional sensors with a distributed sensor network that is integrated invisibly into windows. In addition to the power generated from the thermal energy harvesting, the thermoelectric elements (TE) are also used as temperature sensors that, while being distributed over large area, enable thermal mapping of the area instead of just one or a few values measured from particular points. This smart window can be produced on glass, but the final goal will be the fabrication on transparent flexible organic substrates using Roll to Roll Atomic Layer Deposition (R2R ALD), that can be fixed or retrofitted on existing windows or walls, which will significantly broaden the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis of flow regulated angiogenesis during zebrafish development' in the context of a Seventh Framework call.

assistant: **Objectives**

Angiogenesis, or the sprouting of blood vessels from pre-existing ones is a key process in shaping the vasculature. So far, angiogenesis research has mainly focused on identifying genetic players. My proposed research takes a completely novel approach towards understanding angiogenesis by addressing the question how physiological factors, such as changes in blood flow dynamics, influence endothelial biology. I will furthermore address the question if there is an interaction between genetic and physiological influences during angiogenesis. My proposed research will tackle these outstanding questions in endothelial biology using several cutting edge technologies. First, I will perform long term time lapse imaging of the growing vasculature using 2-Photon microscopy.  Second, I will use an innovative methodology employing zinc finger nuclease mediated gene targeting to rapidly generate mutant zebrafish in genes implicated in mediating the effects of hemodynamics on angiogenesis. Third, I will laser ablate individual blood vessels in living zebrafish embryos to alter blood flow patterns and study the influence of those changes on angiogenesis. These challenging technological advancements will make it possible for the first time to understand how physiological factors aid in shaping the forming vascular system. These findings will have broad applicability to angiogenic processes in many different vascular beds and developmental time points. Importantly, the mechanisms at play during vascular development in the embryo are reactivated in the adult in situations of pathological angiogenesis, such as tumor progression or ischemia. Therefore, applying this knowledge to angiogenesis occuring in pathological settings will provide us with new avenues for improved disease treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sport and social capital in the European Union' under Sixth Framework.

assistant: **Concept**

The Declaration on Sport (1997 Amsterdam Treaty) asked the EU to listen to sports associations when important questions affecting sport are raised. European citizens view sport-governing bodies (SGBs) as essential to European life, and encourage understanding and cooperation between SGBs and the EC. However, little is known about relations between SGBs and their members.This research will: explore the organisational structures of SGBs and the nature of their relationships with their membership at local, regional and national levels; assess which variations are attributable to local cultural differences; assess the impact of SGB association networks on social capital at the local, national, and European levels; assess the involvement of women in these networks, particularly in decision-making capacities; assess practices for dispute resolution; and, highlight the ways in which European policy can most effectively support SGBs and the European citizens they represent. Bocconi University, Milan, will host the research Team.The project will use four case studies (Italy, Denmark, the Czech Republic, and France) to compare the social capital generated by SGB decision-making and membership networks. The primary methods for this research will be semi-structured interviews and multi-sited organisational ethnographies. The multi-national and interdisciplinary Team will promote researcher mobility and academic exchange.The audiences for this research are policymakers, SGBs, and the academic community. Initial dissemination of findings will focus on policymakers and associations, providing short reports, workshops, and conferences to facilitate understanding.Journal articles and a co-authored monograph in later stages will share findings to an academic audience. As such this resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Software for ambient semantic interoperable services' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of the STASIS project is to enable stakeholders, particularly SMEs to participate in the eEconomy within Europe and Internationally by researching into the fields of semantic interoperability within an eBusiness context and developing software platforms and applications which will enable this. It will facilitate their electronic trading with both larger companies and peer SMEs since it will provide both a desktop and web-based service-orientated environment to facilitate the establishment of semantic business connections. STASIS has a strong international perspective in involving many European states and there are also several Chinese partners engaged through the EU-China Science and Technology agreement.The validation will be focused around the strong industrial users in the automotive and furniture sectors although the project is not sector specific and these are only test-beds. Additional sectors will also be addressed through the partners strong links to major standardisation and interoperability organisations within Europe and beyond including the European Standards Institutes eBusiness Interoperability Forum (CEN/eBIF) and United Nations CEFACT organisation. These contacts will also be vital since STASIS uses and is committed to use, and interact with, these and other open standards/bodies as well as all final specifications/techniques being open and deliverables having open source components. Obviously the RTD is performed by a recognised expertise including European/Chinese academics and qualified software/service development companies which will ensure excellent exploitation.It also addresses:-international cooperation, notably with China-strong industrial users join forces with software and services suppliers in building common platforms and applicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plant immunity regulated by cell wall integrity' (SIGNWALLING).

assistant: **Concept**

In their natural environments, plants are under continuous biotic stress caused by different attackers and exposed to abiotic stresses that compromise their survival and offspring. Being well defended against environmental threats throughout the constitutive expression of defensive mechanisms may not always be the best strategy for plants due to the tradeoffs associated to such responses. One of these defensive mechanisms is constituted by the cell wall, a very dynamic and complex structure that is essential to protect plant cells against external threats and also regulates plant growth and development. The functional integrity of the wall during plant development and plant interaction with the environment might be monitored and maintained by a Cell Wall Integrity (CWI or WALLIN) system. In yeast, CWI initiates changes in the cell wall structure and in cellular metabolism to actively maintain functional wall integrity in response to cell wall damage (CWD). Several evidences shows that a dedicated plant CWI maintenance mechanism exists, that integrate many different sources of signalling into one overreaching signalling system (SignWALLINg). The data available suggest that modulation of CWI by cell wall remodelling might be an efficient strategy to improve plant resistance to environmental threats and to obtain crops varieties with improved broad-spectrum resistance to both biotic and abiotic stresses. This proposal aims to enhance our understanding of the fundamental functions of plant cell wall and CWI in the regulation of plant responses to environmental stresses and in particular in the modulation of plant innate immunity. Execution of this proposal will highlight Europe´s ability to address many unanswered questions about the contribution of the cell wall to plant-d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cobalt and lanthanide recovery from batteries' to be submitted under Seventh Framework.

assistant: **Abstract**

The COLABATS project will provide new industrial processes for the recycling of the critical metals Cobalt and Lanthanides and key economic metals Nickel and Lithium, from waste batteries, significantly improving recycling efficiencies and metal purity from existing recovery routes. Primarily Li-ion and NiMH will be targeted using novel task specific ionic liquids (TSILs) to selectively extract the metals. These batteries are found in everyday consumer products such as mobile phones, portable media players, etc., as well as other industrial equipment, and are prevalent in hybrid and electric vehicles, which are becoming increasingly widespread on our roads.TSILs are molecules covalently tethered to a functional group. Targeted species will be low-cost, non-toxic, environmentally benign, and will require minimal or no processing to reuse them.The battery recycling processes will be up-scaled to a pilot system using standard hydrometallurgical equipment and will include other novel concepts to further improve the process. The pilots will be operated in an industrial setting at battery recycling plants and demonstrated to the wider recycling and battery communities.The technology will result in:• Substantially reducing landfill waste by recovering recyclable metals of high purity• Reducing critical metal consumption by increasing recycling efficiencies of spent battery waste. Hence, high purity recovered metals can be recycled into new batteries rather than landfilling or in the case of nickel, processed into lower value stainless steel.• Substantially reducing environmental impact by introducing more sustainable hydrometallurgical processing to replace current standard pyrometallurgical processes. This will reduce energy consumption and emissions of CO2 and other pollutan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable Biomass Conversions by Highly Efficient Catalytic Processes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of a sustainable society requires the efficient use of renewable or sustainable materials and demands the development of selective new methodologies for the preparation of desirable products. In this context we require:(i) a change from traditional stoichiometric, high energy methods that produce huge amounts of chemical waste to mild and clean catalytic processes and(ii) a major step change in chemicals production with fossil fuels being replaced by renewable resources as chemical starter units.In this proposal we have identified a series of collaborative projects that would benefit from the mutual exchange of scientific expertise between several European academic and industrial partners. This collaboration will provide new links within the EU to be established in order to train a new generation of scientists to deliver research excellence in the challenging change from fossil to renewable resources.The challenge to change our societies reliance for chemical production from fossil-fuel based to all-renewable resources is a challenge of enormous scale.This change must be broken down into smaller, manageable components capable of demonstrating the effectiveness of this strategy in order to showcase the transition necessary. In this proposal we will establish links with world leading experts to develop leading examples of this approach and have identified several areas where we believe collaboration can impact. Using the complementary multidisciplinary expertise from the network partners we will:Develop optimal catalysts for ether cleavage in 'real life samples' of lignin for maximising the potential of lignocellulose as a source of fuels and fine chemicals. The most successful catalyst systems developed will be immobilized using advanced fluids and these systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epithelial resistance modulation to treat disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Epithelial barriers are essential for organism’s homeostasis and survival. Defects in resistance of body barrier epithelial tissues and their repair are thought to underlie a range of diseases, which affect millions. Antonio Jacinto’s group has discovered that Septate/Tight Junctions are essential for epithelial repair. These cell-cell junctions can be potentially targeted by candidate compounds that have been identified by Thelial, a Start-Up that will collaborate in this project. In EMODI we will complete preclinical proof of concept of the potential therapeutic activity of two selected compounds, relying on scientific results and technologies developed under ERC starting grant awarded to Dr. Antonio Jacinto. Regarding clinical application, we will focus on rare (orphan) diseases which have been associated to impaired epithelial repair in the gastro-intestinal track for which there are very limited treatment options: Sjoergen Syndrome (SjS) and Eosinophilic Esophagitis (EoE). The plan of activities involves the following steps: 1) Biological efficacy testing of the-1 and the-2 in a zebrafish Tight Junction model and in mouse models of the diseases under focus; 2) Development of IPR based on the biological testing; 3) Consolidate outcomes of steps 1 and 2 into a business plan; 4) Present the business plan to VC funds to seek for extra round of funding. The long-term aim is clinical development of our candidates not only in the context of SjS and EoE but also towards a range of o diseases where impaired epithelial barrier function is impaired and a cause of morbidity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Grenoble high magnetic field laboratory'.

assistant: **Innovation**

Description:The Grenoble High Magnetic Field Laboratory runs jointly by the Centre Nationalde la Recherche Scientifique (CNRS-France) and the Max-Planck Gesellschaft (MPG-Germany) is a leading international laboratory pursuing research in the highest static magnetic fields technically feasible. The laboratory is granting access to user groups from the European Union and Associated States, to carry out their experiments in the facility in static magnetic fields as high as 30 teslas providing them with all local, technical and scientific support for investigations.This includes visible and infrared optical spectroscopy, magnetic resonances, refined transport and magnetization measurements, performed in the high field magnets under extreme thermodynamical conditions including very low temperatures and very high pressures. Open at no cost to users, the laboratory will deliver 1800magnet-hours to about 90 individual researchers during 3 years provided their proposals have been accepted by the international programme committee.Application:Application procedures and technical information can be found on the web-site of the laboratory. Information concerning how to apply are given on the web-site of our laboratory: http://ghmfl.polycnrs-gre.fr.Project Manager:Gérard Martinez, Grenoble High Magnetivc Field Laboratory, Avenue des Martyrs, 25, Grenoble 38042, B.P. 166, France;Tel: +33-47-6881001;Fax: +33-47-6855610;E-Mail: martinez@polycnrs-gre.fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LPMO regulation by (poly)phenolics-active enzymes in Ascomycota' (FuelingLPMO).

assistant: **Concept**

Lytic polysaccharide monooxygenases (LPMOs) are oxidative enzymes employed by fungi to depolymerize cellulose and thus of great academic and industrial (e.g. biorefinery) interest. The exact way or ways natural electron and H2O2 supply occurs to LPMOs during natural fungal LPMO action (and activation) remains unclear. Recent evidence suggests that LPMOs benefit from two oxidative enzymes (i.e. polyphenol oxidases (PPOs) and laccases) that are active on (poly)phenolic compounds. This gives rise to a new paradigm that places lignin as a protagonist in the activation of cellulose degradation, and not simply an obstacle to biomass decay. FuelingLPMO aims to investigate if and how a novel group of uncharacterized flavoenzymes, which I and other researchers have independenlty reported to be commonly co-secreted with AA9 LPMOs by ascomycetes during lignocellulose degradation, can regulate LPMO activity by modifying lignin-derived compounds, as well as deepen the current understanding on the mechanisms involved in LPMO activation by PPOs and laccases. We will use a combination of genome database mining, proteomics analysis and enzyme synergy characterization to investigate the co-occurence of genes encoding for AA9 LPMOs and these putative LPMO regulatory enzymes among Ascomycota, validate their co-secretion during lignocellulose degradation and test their hypothesized role in the regulation of cellulose degradation by AA9 LPMOs in vitro. The project will form a collaboration between the two research laboratories that made the ground-breaking discoveries of the PPO-mediated and laccase-mediated activation of LPMOs and exploit the multi-/interdisciplinary nature of their studies. Our findings will contribute to a more detailed understanding of the network of redox reactions invo