RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A unique cost-effective and point of care (PoC) kit for the non-invasive rapid in vitro diagnosis of meningococcal disease' (PoC).

assistant: **Concept**

Meningococcal disease (MD), caused by Neisseria meningitidis serogroups (mainly ABCXWY), annually affects 1.2 million people worldwide (mainly children and young). Due to its high lethality (8-15% treated patients), permanent sequelae and epidemic potential, MD represents a major public health problem. Despite the societal burden, there is a lack of rapid and accurate diagnostic tools for timely and early treatment that results very costly for healthcare systems (e.g. direct costs valued in € 68 m/hospital/year). In response to the unmet need, BioSpeedia (spin-off from the Institute Pasteur, France) has vast experience in infectious diseases management and is developing the first-ever gold nanoparticle-based immunochromatographic test with demonstrated diagnostic capability for the six Nm serogroups. MeningoSpeed is a non-invasive, accurate (sensitivity and specificity >93%), rapid (<15 min vs PCR: 3h) and cost-competitive in vitro diagnostic test (€45 sample, at least 25 % cheaper than latex agglutination tests and PCR alternatives) for MD diagnosis. Our one-step solution will result on added value for patients, physicians and healthcare purchasers by improving disease monitoring in an accurate and timely fashion way, reducing deaths and sequelae. MeningoSpeed will provide healthcare systems with limited resources with a reliable and cost-effective diagnostic tool, leading to significant cost-savings. MeningoSpeed´s high accuracy and performance under a faster and cheaper cost make it a disruptive solution with great potential for commercial success in the growing point-of-care market (€33 B by 2022, CAGR 10%). Thus, MeningoSpeed is projected to be a profitable business opportunity and a core source of growth for the company (ca. €33 M of accumulated net profit during
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of zinc metabolism in alzheimer's disease. elaboration of a new strategy for prevention and therapy of alzheimer's disease (zinc).' under Fifth Framework.

assistant: **Concept**

Zinc plays important roles in development and functioning of the nervous system and its homeostasis is disturbed in many diseases, including Alzheimer's disease. Elevated level of zinc may play a crucial role in formation of amyloidal plaques characteristic for Alzheimer's disease. Our efforts are directed towards understanding the fundamental principles of zinc metabolism in synergic neurons in brain and finding out the ways of its regulation. Main attention will be focused to structural and functional studies of metallothionein-3 and zinctransporter T-3 and desegregation of amyloidal aggregates by metal cheaters. The final aim of the present project is the elaboration of a new strategy and tools for prevention and therapy of Alzheimer's disease through normalization of zinc metabolism in critical regions of the brain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional analysis of the cdk inhibitor p21 and its regulation by cell cycle dependent degradation' under Fourth Framework.

assistant: **Concept**

Research objectives and content Progression through the mammalian cell cycle is controlled by the tightly regulated activity of cyclin-dependent kinases (cdk's). Both positive and negative regulators of these kinases classify as oncogenes and tumor suppressor genes, respectively, and dysregulation of these activities is implicated in a variety of malignancies. The novel class of cdk inhibitors appears to negatively regulate G1 phase specific cdk's and, thereby, inhibit cell cycle progression. p21 is a cdk inhibitor specifically implicated in mediation of the DNA damage checkpoint, cellular senescence, and differentiation (for review see Harper & Elledge, 1996). Since p21's very complex mode of function is not yet understood and conflicting data on its features were published my research proposal is focused on elucidating the activity of p21 in more detail under different physiological conditions. My well characterized set of newly established monoclonal antibobies to human p21 will hopefully give new insights in target preferences and function of p21 under various conditions. Presently, my major interest is p21's regulation on the level of protein stability, since my own preliminary results demonstrate a quick turnover of the protein, which is mediated by the ubiquitin-proteasome protein degradation machinery. The post-translational regulation by altered protein stability appears to be an essential control mechanism of key cell cycle regulators. Harper, W., and Elledge, S.,; Cdk inhibitors in development and cancer. Cur.Op.Gen.& Dev., 6: 56-64, 1996. Training content (objective, benefit and expected impact) Independent working conditions, a good panel of applyable methods and creative scientific discussions are basics for successful research-standards in the Department
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An electrochemically produced oxidiser for modular, onsite generation of HYdrogen PERoxide' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Hydrogen peroxide (H2O2) has many industrial applications, e.g., as chemical reagent and bleaching agent for textiles and wood pulp. The established production route of H2O2 is the autooxidation/ anthraquinone process, which uses natural gas as both feedstock and energy source.The main objective of HYPER is the demonstration, in industrially relevant environments, of a scalable, modular electrochemical process for H2O2 production with improved efficiency compared to the state-of-art. It will bridge this production with downstream integration into diverse value chains, pulp and paper, textiles and coatings/chemicals, in which strong market opportunities exist for modular, on-site and on-demand H2O2 production. The central innovation in HYPER is the use of persulfate as a stable oxidization intermediate, allowing both storage of renewable electricity and on-demand H2O2 production. HYPER will thus help transform H2O2 production from a large-volume, energy intensive chemical process to a smaller-scale, modular, renewable, electrochemical process. Demonstration of electrochemical production technologies at TRL6 and integration into the three aforementioned value chains will allow HYPER to evaluate the potential of the electrochemical production for further TRL development.HYPER will advance a safe, circular, and cost competitive electrified technology for H2O2 production. The estimated production price of ca. 0.6 €/kg  can be further decreased by the storage of renewable electricity. Implementation of HYPER technology will decrease life cycle CO2 emissions in H2O2 production by up to 75% when 100% renewable energy sources are used. Estimated CO2 emissions reductions are from 1.1 Mt CO2/yr in 2030 to 1.4Mt CO2/yr in 2045, for cumulative CO2 emission savings of more than 19 Mt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cyber preparedness actions for a holistic approach and awareness raising in the MARitime logistics supply chain' (Cyber-MAR), addressing dissemination and exploitation.

assistant: **Impact**

Cyber-MAR is an effort to fully unlock the value of the use of cyber range in the maritime logistics value chain via the development of an innovative simulation environment adapting in the peculiarities of the maritime sector but being at the same time easily applicable in other transport subsectors. A combination of innovative technologies are the technology enablers of the proposed Cyber-MAR platform which is  not only a knowledge-based platform but more importantly a decision support tool to cybersecurity measures, by deploying novel risk analysis and econometric models. CSIRTs/CERTs data collected will be analysed and feed the knowledge-based platform with new-targeted scenarios and exercises. Through Cyber-MAR, the maritime logistics value chain actors will increase their cyber-awareness level; they will validate their business continuity management minimizing business disruption potential. Cyber-MAR will act as a cost-efficient training solution covering the maritime logistics value chain.


**Keywords:** cyber ranges, maritime cybersecurity,maritime logistics value chain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Computational Prediction of Drug Cardiac Toxicity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Many drugs fail to reach the market because of side effects on the heart. The principal objective of this proposal is to create an advanced computational technology for in silico assessment of the efficacy and safety of specific drugs [ICT-2007.5.3(c) (3)], i.e. an open environment comprising validated computational models, tools and numerical methods that will enable simulations of drug actions on the electrophysiology of the human heart. Such simulations will involve modelling of drug interactions at the molecular and cellular level, will extend current technology to enable prediction of the effects of those interactions on the dynamics of the whole heart, and will lead to an understanding of how genetic factors can be used to assess patient-specific risk profiles. This requires a multi-level systems approach, based on multi-scale, multi-physics methods, including computations on adaptive spatial grids and multi-grid time integration. Computations on realistic models at appropriate spatial and temporal scales are currently not feasible, so we will investigate new algorithms and their implementation on high-performance platforms, including a new generation of petaflop computers, to achieve faster than real-time simulation. These tools form part of the infrastructure required to simulate the physiology of major organ systems, thereby contributing to the goal of creating the Virtual Physiological Human (VPH) [ICT-2007.5.3]. The balanced team in this project, including founders of the Human Physiome Project, has decades of experience in the experimental study and modelling of the electrophysiology and mechanics of the heart, while pharmaceutical industry partners bring deep understanding of the mechanisms of drug actions. The results will demonstrate the value of the VP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Knowledge management in research and technology organisations: policies and practices to make your rto competitive in the 21st century' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

A two-and-half-day conference will be held in The Hague from October 11 to 13,2000 on the theme Knowledge Management (KM) in Research and TechnologyOrganizations (RTOs), with emphasis on policies and practices to enhance theperformance and competitiveness of RTOs in the 21st Century. For RTOs from theMPC it is expected to give them a useful platform from which to design andimplement KM in their management systems. The conference is organised under theauspices of the World Association of Industrial and Technological ResearchOrganizations (WAITRO) and the European Association of Research and TechnologyOrganisations (EARTO).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Heritage of Disease: The Art and Architectures of Early Modern Hospitals in European Cities' (ARCHIATER).

assistant: **Concept**

After the Black Death of 1348, hospitals were newly designed to face social disease, further plague’s waves, and new illnesses, e.g. syphilis. Social distancing (like recently with an unknown virus) was the main method to avoid all kinds of contagion. New spatial and safety concepts were developed to care and confine the sick and the poor in structures enhancing the visibility of political or religious agendas. While wars and early globalization contributed to spreading pandemics, charitable bodies exploited their roles to gather capital, which they reinvested in art. Despite an extensive scholarship on hospitals as social institutions, the question of why art and architecture were so vital for hospitals remains open. ARCHIATER tackles this gap, focusing on three objectives: 1) To map hospital visual cultures, agencies and imaginations in European cities before 1750 along terrestrial and maritime routes and according to hospital typology and networks. 2) To analyse the spaces, forms, themes and designs of hospital art and architecture as liminal mediators to manage disease and contagion as well as life passages, healing, death, and salvation. 3) To reconstruct transitions and changing values of hospital materiality and develop ways of ‘curating’ the impressive heritage of premodern hospitals. Bringing together art, architecture, history, and curatorial studies, the project looks at these relations in comparative and interconnected ways. It combines geographical and micro-historical investigations, object-based analysis, and a new conceptual questioning on the ‘liminality’ of hospital art and architecture as mediators between spaces, actors, and intentions in the ‘monumentalization’ of disease, which characterizes historical cityscapes. Addressing these issues will revea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Opening bio-based markets via standards, labelling and procurement' (OPEN-BIO), addressing dissemination and exploitation.

assistant: **Impact**

Application of standards, certification schemes and labels has positive long-term effects on the overall development of the European bio-based product market. Good product information that presents correct claims to industry and public procurers is vital for the usage of these new products. Ensuring the sustainable sourcing of raw materials and the effective bio-content are important additional steps for public confidence. Clear indication of their (comparative) functionality and the optimal possible end-of-life options, needs to underline their positive impact compared to the regular products. Finally, public acceptance comes with clear and harmonized labels on products and packages.The Open-Bio project aims at increasing the uptake speed of standards, labels and harmonized product information lists for bio-based products. It covers research and demonstration on direct and indirect biomass content methods, biodegradability and ecotoxicity tests. Practical solutions for stakeholders, lab and field tests on for instance sampling or capability of being recycled or digested in a gasifier will be studied. Goal is to copy results one-to-one into European standards and product information lists. These form the basis for a database on bio-based products. A label will be developed in order to clearly distinguish bio-based products on the basis of the functionality laid down in standards. Both the information lists and the labels will be tested on their social acceptance via a set of target groups.New research on isotopes, marine bio-degradation and intended end-of-life options such as digestibility and recyclability, distinguishes this project from an on-going FP7 project called KBBPPS. All partners thereof participate in Open-Bio. By participating in the Standardization Commit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improved plant health by the combination of biological disease control methods', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The novelty of this project is the combined use of several well-focussed biologi cal control strategies for effective disease management of the two major aerial fungal plant pathogens (Botryt¡s cinerea and powdery mildew) of important protec ted crops (tomato and cucumber)and of grapes. The control strategies target seve ral developmental stages in the life-cycle of the pathogens that are essential f or initiation and establishment of disease. This approach is going beyond the st rategy of most other programmes in biocontrol which merely integrate single tech niques against specific pests or diseases into pest management schemes. With thi s novel idea, reliability of biological disease control strategies will be impro ved to a degree, where they can fully replace chemical pesticides. In this way p lant health will be enhanced by environment-friendly and sustainable agricultura l methods without the use of chemical fungicides.  The first step is to opti mize those biological disease control systems - (i) plant extracts for induced resistance; (ii) Bacillus antagonist for inhibition of conidial germination a nd (iii) fungal antagonists to suppress pathogen growth - that individually ha ve already been shown by the project participants to effectively target developm ental stages of the pathogens and reduce the level of disease. Once optimized, t he performance of these biological methods will be determined independently in t he greenhouse and in the field, against both B. Cinerea and powdery mildew. The effect of preparation methods and environmental parameters (temperature, relativ e humidity, solar radiation, plant age and type) on the performance and the abil ity to control the pathogens will be established in vivo in order to improve the effectiveness of the individual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Function and regulation of the type 2 vasopressin receptor and 'V2R' in body fluid homeostasis' (AVP-V2R).

assistant: **Concept**

The hypophyseal hormone vasopressin regulates body water balance via the renal vasopressin-type 2 receptor (V2R). Several abnormalities of water balance, in states such as congestive heart failure, kidney, liver and brain disease, are caused by disturbance s in vasopressin action. The role of V2R regulation in these states is poorly understood. V2R is an important drug target with agonists such as dDVAP being used to manage central diabetes insipidus or treat children suffering from nightly urinary incontinence. Furthermore, the V2R is a candidate drug target for antagonists for the treatment of diseases associated with water retention. However, there is an almost complete lack of information of how this receptor is regulated at the protein level. Understanding of the basic regulation at the molecular level may lead to better treatment of several diseases with water balance disturbances.The purposes of the present studies are to use a targeted systems biology approach to:1) Determine the exact segmental and sub-cellular localization of the mouse, rat and human V2R.2) Analyse whether the V2R is regulated with respect to expression or sub-cellular trafficking under physiological conditions.3) Investigate whether V2R expression and sub-cellular trafficking is dys-regulated in pathophysiological conditions, and4) Develop a transgenic mouse with genetic deletion of the V2R in the kidney-collecting duct alone.This model of inherited nephrogenic diabetes insipidus will enable us to evaluate the extent to which the loss of a functional V2R affects the expression levels and function of other proteins that play key roles in water balance. At present, the understanding of multiple water balance disorders is incomplete. A molecular, cell biological and integrated physiological and