RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mitochondria as regulators of fungal virulence' (MITOFUN) targeting Seventh Framework.

assistant: **Abstract**

Fungal diseases represent a significant and growing threat to human health, particularly since the AIDS pandemic and increasing use of immunosuppressive drugs has produced a massive population of people with impaired immunity who are vulnerable to fungal infections.  A great challenge in medical mycology is to understand how fungal virulence evolves. The vast majority of fungal species are not human pathogens and, for those that are, virulence appears to have evolved independently on many different occasions.  Identifying the step(s) that convert an environmental fungus into a human pathogen, as well as subsequent changes in virulence within a pathogenic lineage, is therefore of fundamental importance.  Based on a number of lines of evidence, I hypothesise that a critical regulator of fungal virulence in animal hosts is the activity of the fungal mitochondrion, an energy-generating organelle present in almost all eukaryotes.  I propose to test this hypothesis comprehensively by combining genetic and cell biological approaches with high-resolution imaging methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Flow-Reactor Coupled 3D Printing: Achieving Voxel-Level Control of Out-of-Equilibrium Materials' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nature has optimized the properties of its building blocks by spatially varying hierarchical microstructures within complex form factors. Additive manufacturing techniques, in particular direct ink writing (DIW), are promising pathways towards replicating these systems synthetically, leading to printed materials with tarilored materials properties. However, current DIW techniques do not offer access to out-of-equilibrium materials, greatly limiting printable microstructures. To overcome this limitation, a new DIW technique, termed FloR3D, will be developed in this project. By integrating an evolving chemical reaction into the printing process itself, this Flow-Reactor coupled 3D printing technique allows for out-of-equilibrium microstructures to be generated within the nozzle, which is subsequently trapped upon deposition. Through on-the-fly variations of the relative flow rates into the flow reactor, FloR3D will allow for voxel-level control of the material composition and microstructure, resulting in optimized and spatially-varied hierarchical structures. By incorporating a polymerization-induced microphase separation (PIMS) process, spinodally-decomposed bicontinuous microstructures, which was previously unachievable by DIW, will be printed. Printing these bicontinuous systems, commonly used in nature to exhibit structural coloration, will result in angular-independent structural colored materials with arbitrary form factor. Furthermore, by including photoresponsive monomers within the PIMS system and an in-situ UV source, the materials' refractive indices can be tuned independently of the microstructural feature size, resulting in materials with gradient and spatially-patterned optical properties. Ultimately, beyond the complex photonic materials produced in this pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Heroin addicts and their children : a prospective longitudinal cohort study of treatment outcomes' (CASE).

assistant: **Innovation**

Aim: To conduct comparative research throughout Europe which will lead to the development of pan-European standards in treatment and prevention for heroin addicts and their children.Design: A cohort study of health and socio-economic status of heroin addicts and their children as the addicted parents enter one of the three major treatment modalities, with follow-up for three years.Methods: the children under 5 of all heroin-addicted individuals entering the major treatment modalities in 4 European centres over a 6 month period will be followed up for 3 years and assessed annually using new European standardised outcome measures developed by the partnership. Interventions:1. Maintenance treatments (methadone and heroin maintenance)2. Detoxification treatments (community, residential family, residential adult)3. Non-prescribing supportive interventions.Outcome measures:1. Primary (children's outcomes): Residential status, development, schooling, legal status, and health status, health and social service contacts.2 Secondary (parents' outcomes) Successful completion or retention in treatment, addiction status, risk-taking, criminal status, social status. These outcome measures will be standardised to promote pan-European best practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Carbon Nanomembranes with Sub-Nanometer Channels for Molecular Separation in Organic Liquids', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Energy efficiency is a key principle of the EU’s 2020 strategy for smart, sustainable and inclusive growth, and implementation of this strategy requires innovation in energy intensive industries. Organic solvent nanofiltration (OSN) meets this need—it is a membrane-based separation with the potential to achieve more than 90% energy savings over conventional distillation in the energy intensive chemical industry. Current challenges for OSN are the need for materials with high flux, high selectivity and high chemical resistance. This proposal advocates meeting this need by constructing a membrane with: i) an ultrathin selective layer, ii) uniform pore sizes and iii) a cross-linked network. Carbon nanomembranes (CNMs) are 2D materials made by crosslinking of self-assembled monolayers; this results in a film with single-molecule thickness. CNMs mainly comprise carbon, resulting in chemically-stable separating layers. Also, their molecular structure is tunable by synthesis with purpose-designed molecules. Recently, the Fellow was part of the team which created the first 1.2-nm thin CNM with a high density of sub-nm channels, providing ultrafast permeation of water while blocking the passage of most other molecules.This project will combine the Fellow’s expertise in the development of single-molecule-thick films with the host’s expertise in OSN and interfacial synthesis; it aims to design new nanomaterials for advancing molecular separation in organic liquids. The objectives of the project are to: 1) demonstrate the ability of freestanding CNMs for OSN; 2) explore the tunability of CNMs at a molecular level for improved selectivity; 3) create nanocomposite membranes comprising interfacially synthesized mesoporous films supporting CNM separating layers.This highly innovative a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nmr investigation of temporally and spatially resolved dynamics in porousmedia' (1994-1998).

assistant: **Innovation**

Research objectives and content The research project (duration requested: 24 months) will cover three consecutive stages regarding specific research, impact and complexity. During the first, motion-encoding PFG-NMR techniques will be applied and extended to the study of bulk adsorbent particle and porous packing properties in chromatographic columns, being in close relation to the up-to-date fine particle design and technology. Results will provide extremely important data on intraparticle fluid diffusion and tortuosity (when using porous particles), interparticle convective dispersion and the packings external porosity, as well as on the fluid mass transfer between the stagnant (intraparticle) and moving (interparticle) fluid. In the second stage, this original approach will be extended by the Implementation of fast NMR imaging techniques, now used to spatially resolve in packed chromatographic columns the aforementioned parameters characterizing fluid dynamics. Here, pivotal attention is paid to the actual (axial and radial) homogeneity and long-term stability of the column packings and its improvement for common chromatographic practice. In the final stage, the results acquired and the experience gained with respect to the well-characterized temporally and spatially resolved dynamics in packed chromatographic columns will be applied to the study of more complex (bio)systems and multi-phase fluid dynamics in porous media. It includes the oil/water transport in packed beds of porous particles and porous rocks (enhanced oil recovery), water transport in granules which carry immobilized microorganisms (waste water research), and the mass transfer characteristics in activated carbon (heterogeneous catalysis). Training content (objective, benefit and expected impact) Due t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanisms of chromatin organization and reprogramming in totipotent mammalian zygotes'.

assistant: **Innovation**

Totipotency, the developmental potential of a cell to give rise to all cell types, is naturally achieved when differentiated egg and sperm fuse to form the one-cell zygote. How chromatin is epigenetically reprogrammed to totipotency within hours after fertilisation remains a central question in biology. We aim to address this by investigating the mechanisms of reprogramming and the spatial reorganisation of chromatin in mammalian zygotes. Our interdisciplinary approach combines mechanistic cell biology with genetics and genomics to understand how chromatin reorganisation promotes totipotency and to identify key regulators of this process in zygotes. Molecular insights into reprogramming to totipotency are crucial to understand the essential zygotic stage of sexually reproducing species. A better understanding of how cells naturally reprogram chromatin to totipotency, a state upstream of pluripotency, has the potential to improve induced reprogramming technology and revolutionize regenerative medicine. Our aim is to understand how chromatin is reprogrammed to totipotency. To reach this ambitious goal: 1) We will discover new general concepts of genome organization, as well as reprogramming-specific aspects, by capitalising on our recently developed single-nucleus Hi-C method to dissect spatial reorganisation of chromatin in zygotes. We will investigate the relationship between chromatin reorganisation and transcription. 2) We will uncover mechanisms of zygotic reprogramming by elucidating the loci and factors that support active DNA demethylation during reprogramming of the paternal genome. 3) We will illuminate the origins and contributions of the oocyte since the factors responsible for reprogramming likely reside as proteins or RNA in the unfertilized egg. Overall, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a portable miniature mass spectrometer to monitor important, but technically difficult parameters in aquaculture' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The AquaMMS project will improve today's SoA by  developing a robust and portable miniature mass spectrometer, which will monitor online a wide range of vital water quality parameters simultaneously. AquaMMS will be suitable for use primarily in land-based aquaculture industry, but other markets are also relevant including environmental monitoring sector and the water supply industry. This technology will provide the fish farmer with advance warning of a broad range of potential pollutants, like toxic metals, phosphates, nitrites, nitrates, hydrogen sulphide and geosmins. These pollutants can otherwise inflict chronic stress on the farmed fish resulting in disease outbreaks and/or poor product quality, which means lost profit to the fish farms. Most of these parameters are at present technically challenging to measure accurately on a regular basis and may only be analysed when problems arise on the farm and samples are sent for more comprehensive analysis at external laboratories. Q-technologies (UK) has successfully developed miniature mass spectrometry (MMS) technology for the oil and gas industry, and has seen the need and potential in developing and marketing a similar system for the aquaculture industry. Therefore, they have taken the initiative to propose the AquaMMS project by combining forces with the  SMES, Faaltech (Ireland) and BAMO (Germany). Together, these SMEs will form the production and distribution chain of the product post project. Anglesey Aquaculture Ltd (UK) and Telemarks Roye as (Norway) will take part in the project representing the end user community and will act as a test sites for the developed technology. Anglsey Aquaculture and Telemarks Roye will benefit from improved production by using AquaMMS ahead of its competitors. The RTDs, Universit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional in vivo two-photon imaging of fear memory traces in identified neuronal networks of the amygdala' (2007-2013).

assistant: **Innovation**

Memory formation is one of the most sophisticated and fascinating functions of the nervous system. Our brains remain plastic throughout life and enable us to store and access an amount of information that no computer could cope with. While the physiological mechanisms underlying learning have been studied extensively using in vitro preparations, much less is known about how memories are stored at the level of local neuronal circuits in the intact animal. This is an essential question since the dynamic interaction of neurons in their networks is absolutely critical to any form of higher brain function.  This proposal outlines a strategy to elucidate how memory formation and extinction alters the activation patterns of local, identified neuronal networks. We will apply a novel and multi-disciplinary approach which combines the recently devised technique of in vivo two-photon calcium imaging using GRIN lenses with established molecular (transgenic mouse lines) and behavioural (fear conditioning) approaches. This will enable us to optically record the activity of many neurons simultaneously and to discern the two major neuronal populations, principal neurons and interneurons, which have opposing roles in the brain. This strategy will be used to study how fear memories manifest themselves in the mouse amygdala. In addition, we will characterise the mechanisms of fear generalisation and extinction. These phenomena are implicated in several human anxiety disorders which afflict an estimated 13% of the population in the EU. Our results will help to better understand the underlying causes of these conditions and potentially reveal novel strategies for pharmaceutical intervention. In addition, this research will define novel concepts on memory storage at the network level, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unfair transitions? A critical examination low-carbon energy pathways in the EU from a domestic energy vulnerability perspective' (TRANSFAIR).

assistant: **Innovation**

Energy transitions towards sustainability are driven by the need to reduce the environmental impacts of energy consumption, namely those related to carbon emissions. However, it is feared that a large scale deployment of low-carbon solutions that disregards pre-existing socio-economic and material inequalities may result in transitions deepening disparities or creating new energy-related vulnerabilities. Such prospect is particularly worrying as tens of millions of EU households are currently experiencing energy poverty, i.e., they are unable to access socially- and materially-necessitated levels of domestic energy services. Against this background TRANSFAIR aims to identify, conceptualise and empirically substantiate the ways in which the EU’s “transition to a low-carbon, secure and competitive economy” may (or not) be reproducing and reinforcing current energy vulnerability trends in Member States. To this end the research will combine the political ecology and environmental justice frameworks with transitions theory and multi-level governance perspective, conduct a critical, integrative review of scientific and policy literature and carry out an empirically-based examination of two complementary case studies: renewable electricity cooperatives in Spain and advanced thermal retrofits of multi-family buildings in Hungary. The experienced researcher Dr Sergio Tirado Herrero will carry out the research in an internationally renowned political ecology and environmental justice research centre – the Institute of Environmental Sciences and Technologies (ICTA) of Universitat Autònoma de Barcelona (UAB) – under the supervision of Prof Giorgos Kallis, TRANSFAIR will equip the experienced researcher with advanced qualitative data collection and analysis skills and further his u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multimodal Imaging of rare Synucleinopathies' (MultISyn), addressing dissemination and exploitation.

assistant: **Impact**

Despite remarkable progress in the understanding of the molecular pathogenesis of neurodegenerative diseases (NDD), no causative or disease-modifying treatment is currently available. Aggregation of misfolded proteins are thought to play a crucial role in the pathogenesis, but attempts to exploit this knowledge for novel treatments have not been successful. Also, pathogenetically relevant biomarkers of protein aggregation are lacking.In order to overcome this critical road-block, we have assembled an interdisciplinary consortium, consisting of world-leading experts in structural biology and ligand development, multimodal neuroimaging, animal models and clinical trials to develop a novel imaging system for combined simultaneous molecular and functional imaging (PET-MRI/fMRI) for two rare diseases caused by excessive accumulation of misfolded alpha-synuclein (αSYN), multiple systems atrophy (MSA) and parkinsonism caused by mutations in the alpha-synuclein gene (SNCA), which will serve as proof-of-principle models for the more common and heterogeneous NDD. With this technology we will pioneer the monitoring of protein aggregation as a biomarker for therapeutic effects in the framework of individualized causative treatment. The central aspects of the work-flow including ligand design, software development and drug trials will be driven by three highly specialized SMEs, while translation to animal models and clinical use will be implemented by top academic centers. The groundbreaking progress will include:1.Establish a multimodal imaging algorithm based on a new PET tracer and embracing structural and functional MRI methods to yield an αSYN specific tool2.Test this multimodal, molecular neuroimaging algorithm in animal models with regard to its potential for diagnosis, mirro