RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'In vivo super-resolution imaging of synapses in the hippocampus'.

assistant: **Innovation**

The hippocampus is a deeply embedded region in the mammalian brain that has long been considered the archetypical center for memory formation. Hippocampal neurons process information by integrating a vast number of synaptic inputs via dendritic spines. These postsynaptic structures are highly dynamic and their plasticity is hypothesized to be important structural correlate of the memory trace. However, due to their nanometric size and high density, it is extremely challenging to study the function and regulation of dendritic spines under realistic experimental conditions. Indeed, conventional light microscopy fails to properly resolve them while electron microscopy only provides snapshots from fixed brain sections. Therefore, our view of spine dynamics remains very incomplete, limiting our understanding of the synaptic mechanisms underlying brain physiology and animal behavior.Leveraging recent advances in optical microscopy, adaptive optics and mouse brain surgery, this project seeks to establish a new paradigm based on correlating super-resolution imaging of dendritic spines in living mice with behavioral analyses of the capacity of mice to learn and remember things. To this end, I will (1) establish super-resolution imaging of spines in the deeply embedded hippocampus, (2) perform longitudinal imaging to determine spine morphology and turnover over the course of weeks in live animals and (3) investigate how spine plasticity correlates with memory performance in the same animal.This project builds on my expertise in biophysics and advanced microscopy and will offer me a unique opportunity to contribute to a dynamic research field at one of the top places for neuroscience in Europe. Going significantly beyond the state-of-the-art, this project will push the frontier in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intuitive Physical Interfaces to the WWW' in the context of a Fifth Framework call.

assistant: **Objectives**

As an alternative to GUIs, we propose a Tangible User Interface (TUI) for navigating the WWW that places priority on direct manipulation - users control the system and navigate through information by selecting and positioning physical objects, not just representations on a PC screen. This is genuinely multimodal, combining a physical element with digital representations (graphics, audio) that provide a dynamic element - showing how manipulations change the underlying data. The topic of searching and retrieving Internet information has not been addressed by previous TUI work. WebKit combines an examination of novel multimodal interfaces with innovative work in semantic web technology and information management. We will develop an innovative end-to-end system, expected to yield new IPR (e.g. physical query language paradigms) and commercial exploitation opportunities. The system will be extensively tested in schools and homes by 5 - 13 year old children.Objectives:We will develop a series of Tangible User Interface (TUI) applications for information search and retrieval, to validate and refine them, and identify those with greatest exploitation potential. We will develop an end-to-end platform which will be specifically optimised for WWW applications, and which will permit rapid development of new applications. We will trial this system extensively with pupils and teachers in at least 2 schools, already identified, together with a number of homes. Trials will be a significant part of the project, lasting at least 12 months. We will evaluate the results and use this to further refine the applications and underlying platform.Work description:An object-based interface will be created using RFID (radio frequency identification) tags, communicating with a remote server to retr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Analysis of sequential psychological data' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

University of Liverpool Department of Clinical Psychology RESEARCH FELLOW Statistical Analysis of Sequential Psychological Data Applications are invited for a full-time post as research fellow for a two-year project developing novel statistical methods of analyzing sequential psychological data. The post, supported by the Marie Curie Foundation, will involve a number of elements. The successful applicant will work with members of the department to re-analyze existing databases collected in the course of Medical Research Council and other funded research into doctor-patient communication, psychotic conditions and personality disorders in order to examine sequential and iterative patterns. They will assist the members of the department develop new skills in these areas. They will collaborate with members of the department to collect new data examining sequential relationships and will collaborate in applications for new grant-funded research. The successful applicant will be employed in the Department of Clinical Psychology, University of Liverpool. This Department, which has a history of more than thirty years, consists of a lively, friendly and productive group of people dedicated to high quality teaching, to innovation in clinical practice and to excellence in research. The research group specifically supporting this fellowship consists of 10 individuals with international reputations in the study of clinical communication, psychotic experiences and personality disorders. Applicants should have a PhD in psychology or a relevant social science discipline with appropriate experience in the use of novel statistical and computational analytic techniques. It is expected that the successful applicant will have a number of peer-review publications that include the use of nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'StrUcture PREserving Methods on Unstructured grids for continuum Mechanics' (SUPREMUM) under Horizon Europe.

assistant: **Objectives**

SUPREMUM aims to develop and theoretically study innovative structure-preserving (SP) numerical methods to solve challenging non-linear hyperbolic partial differential equations (PDE) modelling continuum mechanics. The ultimate groundbreaking goal consists on devising the first existing numerical methods simultaneously verifying at the discrete level all structural properties of the continuous models: provable thermodynamical compatibility, so that the systems satisfy an extra conservation law for the total energy in order to rigorously prove non-linear stability; conservation of equilibrium solutions, needed to perform very long-time stable simulations; verification of natural involution constraints, of the divergence and curl type; and preservation of the asymptotic limits, arising for some characteristic scales tending to zero. We will devise efficient high order numerical schemes combining different families of numerical methods on unstructured staggered grids configurations, leading to the advance of fundamental mathematical knowledge on numerical analysis. The use of an arbitrary Eulerian-Lagrangian approach will allow the design of an efficient and accurate fluid structure interaction (FSI) solver based on the unified hyperbolic Godunov-Peshkov-Romenski (GPR) model of continuum mechanics able to represent both solids and fluids. Fundamental progress in practical applications of the developed methodologies will initially target the design of a monolithic approach for the simulation of  entire cardiovascular systems, coupling 1D blood flow models to the 3D FSI approach. Finally, we will build the bridge between SP methods for hyperbolic PDEs and reduced order modelling (ROM) breaking the frontiers of present research to obtain a novel SP-ROM approach for conservati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced intelligence and close-loop control for Crystallisation of API’s (Active Pharmaceutical Ingredients)'.

assistant: **Objectives**

The project aims to address key challenges of the pharmaceutical industry related to the consistent supply of active pharmaceutical ingredients (APIs) which are formed through crystallisation processes. Over 80% of the worlds API’s have crystallisation steps. The current method of determining process performance is a combination of off-line analysis of the quality attributes of the API crystals after the crystallisation process is complete. This methodology does not control the manufacturing process and leads to a variable quality product, variable yields and a large proportion of rework batches, costing the API industry in excess of €10B/year. SmartCrys is an integrated solution for API processing issues of (1) in-line PAT Analysers to measure the critical quality attributes of the crystals, (2) Manufacturing Intelligence to interpret the data and decide whether process adjustments are required, (3) Process Automation which enable the automatic adjustment of the process to take place and (4) Data Analytics which enable visibility of all process data in real-time. SmartCrys enables rapid process development and subsequently self-adjustment of crystallization processes in real time, targeting an addressable market for SmartCrys of €20B. Through engagement with its customer base (8 of the top 10 Pharma companies worldwide) and the regulators, Innopharma have identified a technological gap in in-line process control among API manufacturers. SmartCrys will consolidate Innopharma’s position as one of the world’s leaders in Advanced Analytical Technologies within the pharmaceutical sector, and provide an opportunity to increase company turnover from €8M to €23M over the next 5 years and to grow staff from 45 to 65. It will also contribute to the continued competitiveness of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mathematical and computational foundations for modeling cerebral fluid flow.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Your brain has its own waterscape: whether you are reading or sleeping, fluid flows through the brain tissue and clears waste in the process. These physiological processes are crucial for the well-being of the brain. In spite of their importance we understand them but little. Mathematics and numerics could play a crucial role in gaining new insight. Indeed, medical doctors express an urgent need for multiscale modeling of water transport through the brain, to overcome limitations in traditional techniques. Surprisingly little attention has been paid to the numerics of the brain's waterscape however, and fundamental knowledge is missing.In response, the Waterscales ambition is to establish the mathematical and computational foundations for predictively modeling fluid flow and solute transport through the brain across scales -- from the cellular to the organ level. The project aims to bridge multiscale fluid mechanics and cellular electrophysiology to pioneer new families of mathematical models that couple macroscale, mesoscale and microscale flow with glial cell dynamics. For these models, we will design numerical discretizations that preserve key properties and that allow for whole organ simulations. To evaluate predictability, we will develop a new computational platform for model adaptivity and calibration. The project is multidisciplinary combining mathematics, mechanics, scientific computing, and physiology.If successful, this project enables the first in silico studies of the brain's waterscape across scales. The new models would open up a new research field within computational neuroscience with ample opportunities for further mathematical and more applied study. The processes at hand are associated with neurodegenerative diseases e.g. dementia and with brain swel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Novel materials and system designs for low cost, efficient and durable PEM electrolysers'.

assistant: **Concept**

Water electrolysis based on PEM technology has demonstrated its applicability to produce hydrogen and oxygen in a clean and safe way. Systems have been demonstrated in a wide range of niche applications with capacities from << 1 Nl/hrs to 30 Nm^3/hrs.PEM electrolysers offer efficiency, safety and compactness benefits over alkaline electrolysers. However, these benefits have not been fully realised in distributed hydrogen generation principally due to high capital costs.Principal reasons for high capital costs of present state of the art PEM electrolyser are:-use of expensive materials (noble metals, perfluorinated ion-exchange membranes),-high material usage (e.g. catalyst loading, thickness of bipolar plates),-limited durability of the main components (membrane, electrode, current collectors and bipolar plates),-complex stack designThis project will take advantage of the progress beyond the state of the art achieved by the partners involved in the NEXPEL project. In the initial phase of this project, durability studies of electrolyser stacks developed in NEXPEL will be performed. The stacks will be run at different operating conditions (low pressure, constant load, fluctuating load coupled with RES). Invaluable data and post mortem analyses can be extracted from this demonstration part of NEXPEL and fed into the further development of novel materials for and design of cost competitive, high efficiency, small scale PEM electrolysers for home/community use.The functionality of the novel materials will be proved on the laboratory scale with a small electrolysis stack in the 1-kWel range. By minimising electrochemical losses in the stack, a system design will be developed which enables an overall efficiency > 70 % (LHV). The improved materials will also be made available t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'P4SB – From Plastic waste to Plastic value using Pseudomonas putida Synthetic Biology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

P4SB is about the utilization of the conceptual and material tools of contemporary Synthetic Biology to bring about the sustainable and environmentally friendly bioconversion of oil-based plastic waste into fully biodegradable counterparts by means of deeply engineered, whole-cell bacterial catalysts. These tools will be used to design tailor-made enzymes for the bio-depolymerization of PET (polyethylene terephthalate) and PU (polyurethane), but also for the custom design of a Pseudomonas putida Cell Factory capable of metabolizing the resulting monomers. Pseudomonas putida will undergo deep metabolic surgery to channel these diverse substrates efficiently into the production of polyhydroxyalkanoates (PHA) and derivatives. In addition, synthetic downstream processing modules based on the programmed non-lytic secretion of PHA will facilitate the release and recovery of the bioplastic from the bacterial biomass.These industry driven objectives will help to address the market need for novel routes to valorise the gigantic plastic waste streams in the European Union and beyond, with direct opportunities for SME partners of P4SB spanning the entire value chain from plastic waste via Synthetic Biology to biodegradable plastic. As a result we anticipate a completely biobased process reducing the environmental impact of plastic waste by establishing it as a novel bulk second generation carbon source for industrial biotechnology, while at the same time opening new opportunities for the European plastic recycling industry and helping to achieve the ambitious recycling targets set by the European Union for 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transform 4 European Research and Innovation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Transform4Europe (T4E) is a university alliance of proven excellence in strategic collaboration. It has been awarded European funding to pursue joint strategies in education and mobility, focussing on collaboration between the universities and a wealth of non-university stakeholders from the surrounding regions in a multi-actor knowledge and innovation ecosystem. For the T4E universities, the logical next step is to capitalise on this ecosystem to transform their achievements in research and innovation. Together, the diverse actors in the T4E ecosystem can serve as powerful engines for the mutual development of innovation and performance capacities, jointly fostering both research of excellence and impact, and smarter, sustainable, competitive regions. Transform 4 European Research and Innovation (T4ERI) will devise new strategies to harness this untapped potential, with the focus mission digital and environmental transformation for smart, sustainable and inclusive regions. It will develop a joint agenda for research and innovation, a joint strategy for attracting and retaining outstanding researchers, and a joint strategy to open science to all members of the T4E ecosystem. True to the essence of the alliance, T4ERI will systematically collaborate with regional stakeholders from business and industry, culture, politics and civil society at every step of the process. By 2024, T4ERI will have significantly increased collaboration in research and innovation across all disciplines, will have enabled joint access to key research infrastructure across the alliance, and will have targeted joint action plans to launch one or more major joint research centres relating to its focus mission, to attract and retain excellent junior and established researchers, and to foster engagem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evolution of a new stable phenotype: a genetic, developmental and behavioural analysis' under Seventh Framework.

assistant: **Concept**

How robust phenotypes evolve despite developmental noise remains unclear. Individuals from natural populations usually display more stable phenotypes than laboratory mutants and hybrids. This suggests that there are genetic mechanisms that stabilize phenotypes and that these differ between isolated populations. We want to address here an unexplored yet fundamental question in biology: how does a stable phenotype appear during evolution? We will focus on the evolution of a new genital sensory organ pattern in Drosophila santomea. We aim to better characterize the molecular mechanisms that stabilize this recently evolved phenotype. Our goal is three-fold: (1) characterize and compare the development of these structures in D. santomea and its closely-related species, (2) identify the underlying genes and mutations that act collectively to produce a robust phenotype in pure species, and (3) unveil the selective forces at play on this evolved phenotype. Our combination of various powerful approaches in a tractable model system should provide important insights and concrete molecular data on phenotypic robustness and evolution. My PhD on Drosophila sensory organ development and my post-doc on the delicate genetics of Drosophila evolution have placed me in a unique position to successfully tackle this far-reaching research program.