RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modular High Speed X-ray Detection and Sorting Systems for Production Process Control and Packaging Quality Control' to be submitted under Sixth Framework.

assistant: **Abstract**

The problem solving approach is the current limitations in application flexibility, sensitivity, speed and costs of on-line industrial X-ray inspection systems applied for food, packaging, general manufacturing and novel materials and combinations. The idea involves development of:(i) a novel modular approach for the design, installation, operation, maintenance and servicing industrial X-ray systems (the modular concept);(ii) a novel, fast and ultra-sensitive X-ray scanning detector, that subsequently is implemented as one of the modules of the modular concept.A modular X-ray system design modular involving fundamental technology sub-systems will create a concept that agrees with demands for novel, cost-effective and flexible manufacturing. Apart from a novel shielding design, the project integrates the development of novel detector technology that enables the inspection on-line of e.g. new composites, polymers, packaging, light food products and micro-mechanical devices. Novel CdTe technology shall result in a 500 mm long scanning detector, enabling the improvement of sensitivity by a factor of 3-4, improving resolution from 0.4 mm to 0.1 mm for industrial on-line scanning detectors, improving on-line inspection speed to 120 m/min, and facilitating compact design. Additional technology modules are based Japanese and American competence with relations to IMS framework. The commercial benefit of the project relates to savings on:-investment (due to lower system complexity), expectably by 20-40%;-usage (due to higher usage by making possible the use on different lines; depending on manufacturing details this may be up to 50-80%) ;-maintenance (due to intelligent surveillance and due to shorter down time caused by the flexible design);-servicing and savings on reducing dow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ionic Neuromodulation For Epilepsy Treatment' (IN-FET) under Horizon 2020.

assistant: **Objectives**

There is a need for a paradigm shift in the treatment of drug-resistant epilepsy. Several routes have been explored to modulate or silence dysfunctional neural circuits, through genetic, electrical, magnetic or optical means. All have serious limitations due to the unphysiological mechanisms used to regulate neuronal activity. In IN-FET, we address this issue by manipulating the elementary building blocks of cell excitability: ions. IN-FET tackles the visionary idea of altering neuronal firing and synaptic transmission by direct ionic actuation at the microscopic scale, while monitoring cell responses by arrays of nanoscale transistors. We will develop and test, in vitro, the use of active polymers to trap or release electrochemically specific ions in the extracellular milieu surrounding neurons. These will be integrated with ion sensors and ultra-sensitive nanowire arrays, offering closed-loop regulation of cellular electrical activity. We will deliver for the first time a device that can physiologically modulate the neuronal membrane potential, the synaptic release probability, and glutamatergic NMDA receptors activation by altering potassium, calcium, and magnesium ionic concentrations in a controlled and spatially-confined manner. High-resolution simultaneous probing of cell activity will be performed by Si-nanowire vertical transistors, penetrating the membranes and detecting the cell electrical activity at unprecedented spatial and temporal resolutions. In conclusion, IN-FET's multidisciplinary consortium brings together state-of-the-art electrochemistry, 3-d nanofabrication, nanoelectronics, and numerical simulations, and combines neuronal biophysics to device modeling. IN-FET will thus establish the proof-of-principle for a breakthrough biocompatible neuromodula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High resolution seismic imaging of the Earth's Mantle using techniques from oil exploration seismology', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Seismic tomography is the primary methodology used to constrain the structure of the deep Earth. Present tomographic images of the mantle are still fuzzy, however, with poor resolution compared to images of the shallow crust obtained in seismic experiments for oil exploration. Small-scale structures, like undulations of the transition zone discontinuities in the mantle or mantle plumes, which produce large volcanoes at the surface (like Hawai or Iceland), are important for understanding mantle dynamics. At the present time, these structures are below the resolution of classical tomographic methods.Recent deployments of dense arrays of broadband stations, both in North America and in Europe, should result in a tremendous improvement in the resolution of tomographic models. In particular, it is now possible to apply methods developed in the oil industry to study the structure of the deep Earth at both regional and global scales. This project aims to adapt an exploration technique, currently under development, to be used on regional and global data.This technique uses multiples (waves that have interacted more than once with internal heterogeneities) to detect the thus far invisible small-scale structures of the Earth's interior. This project will encourage communication between researchers from different countries and in different fields of Earth science. These sorts of exploration and global seismology collaborations are just beginning but have great potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced Space Cloud for European Net zero emissions and Data sovereignty' (ASCEND).

assistant: **Concept**

This proposal introduces a pioneering new on-orbit services system concept which would rapidly industrialize the European space ecosystem, making Europe a world leader in robotized and sustainable modular infrastructures as well as reusable launchers, with additional competitive benefits for a sustainable European digital industry and sovereign cloud autonomy.European space technology has now reached a level of maturity that makes possible a revolutionary – yet feasible – endeavour: the installation of internet data centres in orbit, in order to reduce the exponential impact of digital technology on energy consumption and on climate warming. The installation of large modular space infrastructures with robotic assembly, megawatt level space-based solar power, high throughput optical communications, low cost and reusable launchers, is now within the European space industry’s capability.The goal of the proposed study is to demonstrate that placing future data centre capacity in orbit, using solar energy outside the earth’s atmosphere, will substantially lower the carbon footprint of digitalization. Space data centres could therefore become an active contributor to the EC Green Deal objective of carbon neutrality by 2050, which would justify the investment required to develop and install such a large space infrastructure system. It would also strengthen Europe’s digital sovereignty and autonomy, for a sustainable and prosperous digital future.Given the ambition and huge potential impact of this project, which would become a major European flagship program, a broad system-level feasibility and business study is necessary. For that purpose, the ASCEND consortium has brought together major players in the fields of environment analysis (Carbone 4, Vito), data centres architectu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GAIA-BInaries: Formation and fundamental pRoperties Of Stars and planeTary systems' (GAIA-BIFROST).

assistant: **Concept**

Systems with close stellar-mass or planetary-mass companions are ubiquities in the universe. However, the processes that shape the architecture of these systems are still not understood. By 2021 the GAIA mission will provide astrometric+radial velocity orbits for millions of multiple systems. For the vast majority, GAIA will measure only photocenter displacements and not be able to resolve the individual components, preventing masses and orbital statistics to be derived.  The aim of the GAIA-BIFROST project is to exploit the GAIA sample in order to identify the processes that govern the formation and dynamical evolution of binaries and planetary systems. Using VLTI+CHARA interferometry we will resolve up to ∼6000 GAIA binaries in the continuum and in spectral lines, allowing us: (a) to derive precision dynamical masses, ages, and comprehensive orbital parameter statistics that is needed to discern between different binary formation scenarios; (b) to measure the spin-orbit and spin-spin alignment for hundreds of GAIA star-star and star-planet systems. This will constrain the origin of the orbit obliquity for stars and planets, providing unique information about their formation process and dynamical history; and (c) to image companion-disk interactions in young binary systems and use them as benchmark for studying the hydrodynamical processes that determine the system architecture at formation.  Furthermore, our survey will provide a legacy data set of dynamical masses and precision ages for (literally!) thousands of stars, by far exceeding all earlier work in these areas. This will impact many areas of modern astrophysics, including studies on stellar evolution and Galactic Archaeology. To unlock these powerful new observational avenues, it is important to resolve GAIA b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Taxation, Heterogeneity and Employment""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of this project is to study the proper design of benefit and tax programs that promote employment and reduce inequality when individuals are heterogeneous in several dimensions. To do so, we will develop original mathematical models some of which will relate optimal taxation theory to other strands of economic theory (e.g., modern labor economics) and to the literature about equality of opportunity, which lies between social choice theory and philosophy. The nature of the assumed unobserved heterogeneity between individuals is very important for the predictions derived from optimal taxation models. Optimal income tax problems typically restrict individuals’ heterogeneity to one-dimension: their innate ability.Although incentives problems with multi-dimensional heterogeneity (a.k.a. multidimensional screening problems) are empirically relevant, they are notoriously very hard to treat. The THE project aims at (1) elaborating a toolbox to solve these problems and (2) developing a wide range of applications for this toolbox. To solve multidimensional screening problems, we propose to: (i) develop recent results obtained using a random participation framework, (ii) build up on the type aggregator technique and (iii) extend the techniques used in the literature on optimal transportation.Beside these technical contributions, the project will allow us to address three original applied economic questions. First, what is the tax schedule over the entire earnings distribution that satisfies equality of opportunity? Second, what is the optimal tax schedule when there are both skill heterogeneity and gender-specific responses in terms of labor force participation decisions? Third, should workfare be used when labor supply is simultaneously modeled along the participati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The advent of the Iron Age in cell death', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The recognition of distinct regulated cell death pathways presents tantalizing possibilities for gaining control over life and death decisions made by cells to both prevent age-dependent (neuro)degenerative diseases and to fight cancer. For decades, apoptosis has been considered as the sole form of regulated cell death, while others were deemed unregulated, necrotic. In this context, pioneering work originating from my group enabled to establish “ferroptosis” as an iron-dependent cell death modality that is marked by the oxidative destruction of cellular membranes.  Ferroptosis has sparked overwhelming interest in the last few years not only because it harbours many pharmacologically tractable nodes, but as it is likely induced only under pathological conditions, thus opening the unique opportunity for a broad therapeutic window of novel ferroptosis modulators. While some of the molecular players, metabolic contexts and respective small molecule inhibitors and inducers of ferroptosis have been recently described, pivotal questions have remained unanswered.  In a holistic approach this project is conceived to tackle these fundamental questions by providing answers to (i) whether there are yet-unrecognized key ferroptosis nodes that may explain why certain cells are highly vulnerable to ferroptosis while others are not, (ii) the nature and subcellular compartment where the initial ferroptosis priming signal is being generated and (iii) why certain cells and tissues die by apoptosis while others succumb to ferroptosis.  Successful implementation of the herein proposed aims will yield novel ferroptosis regulating genes as potential future drug targets, decipher and localize the death signal affording the rationale design of refined small molecule ferroptosis modulators and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In Pursuit of 'Legality' and 'Justice': Minority Struggles in the Russian Empire and the Soviet Union' under Horizon Europe.

assistant: **Concept**

The Russian Empire and the Soviet Union are rarely associated with the rule of law. And yet, the notions of legality and justice greatly mattered in both: political and cultural elites invoked them as much as the wider citizenries. While existing literature has addressed legality and justice in studies of state policy and intellectual opposition to the two orders, there is little recognition of how instrumental they both were to ethnic and religious minorities. Whereas religion was one of the key determinants of rights, privileges, and obligations in the empire, nationality, understood in ethnic terms, replaced religious affiliation in this capacity under socialism. Being part of a minority could mean open or subtle forms of discrimination. Yet, such discrimination was neither automatic nor did it go unchallenged. This project therefore explores the ways in which minorities, from the Russian Empires Great Reforms of the 1860s to the dissolution of the USSR in 1991, routinely invoked and employed legality and justice to enforce their rights. It argues that the systems allowed, even encouraged, them to do so. What is more, minorities were also represented among the political and cultural elites, from imperial lawyers to Soviet party officials. What did minority actors expect when they called on justice and legality? More importantly, how and to which degree did this strategy help them defend their rights in two highly authoritarian states? While there are obvious differences between the imperial and Soviet periods in this regard, there are also substantial similarities. To track these, the project proposes an ambitious multi-sited enquiry, combining an analysis of published sources with extensive work in regional and central archives, and oral history. This ground-breakin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Memory and innate-like B-cell subsets: deciphering a multi-layered B-cell response in mice and humans' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

B cells are the main actors of successful vaccines, and their protective capacity relies on several subsets with innate-like and memory properties that fulfill different effector functions. In the present project, we wish to develop approaches in both mice and humans, to confront the similarities and the differences of their B cell responses. The three aims proposed are:1) To study the different B cell subsets and TFH cells engaged in a memory response through the use of a new mouse reporter line allowing their irreversible labeling (inducible Cre recombinase under the control of the Bcl6 gene): this will be performed in different conditions of TH1 vs. TH2 polarization, as well as during a chronic viral infection, in which virus-specific antibodies have been shown to be required to control the disease (in collaboration with D. Pinschewer, Basel)2) To study whether the lifelong persistence of B cell memory, as occurs for memory B cells against smallpox that we can obtain at high purity from aged donor's spleens, corresponds to a specific transcriptional program at the miRNA, lncRNA or mRNA level, as well as a specific cell homeostasis 3) To discriminate the specific effector function of human marginal zone and IgM memory B cells in, respectively, T-independent and T-dependent responses, as well as their specific differentiation/diversification pathway.The general goal is to delineate the regulatory pathways leading to the activation and persistence of the different B cell subsets, allowing for a better understanding of the conditions leading to their pathological or beneficial mobilization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Progress in Partial Differential Equations' in the context of a Fifth Framework call.

assistant: **Objectives**

Since the nineteenth century partial differential equations (PDEs) have held a central position in mathematics. In the last 15 to 25 years the influence of methods used in PDEs has continued to increase and now penetrates into most areas of both pure and applied mathematics. The subject continues to evolve rapidly.The main purpose of the conference is to bring together leading experts in this broad and fast- moving area with the objective of delivering a series of high-level, first-class lectures on recent important developments. Particular attention will be paid to developments in PDEs which relate to other fields such as geometry, mathematical physics and stochastic analysis.Topics that will be covered include: progress in the theory of regularity and singularity of solutions for nonlinear equations, which are crucial to the understanding of the intrinsic structure of PDEs and important in their application in physics and mechanics; and new developments in geometry -related PDEs which have brought new ideas into the field and which also underlie recent progress in many classical geometric problems (including important ones originating in general relativity).The Organisers expect the meeting to complement the existing activities in 2001, which together will influence the future direction of research in PDEs.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00240-1.pdf