RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'First-principles theory of spatial dispersion in electromagnetic response of solids: Applications to natural optical activity and magnetoelectric effect' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The global objective of the project is to develop a theoretical framework for the first-principles description of the macroscopic electromagnetic response of solids with a full and accurate account of the spatial dispersion and memory effects. The new scheme will be applied to study two fundamental properties of extended systems: the natural optical activity and the magnetoelectric effect in crystals of technological relevance, such as multiferroics and topological insulators. We should state that at present there is no theory able to model the frequency-dependent response of extended systems with the full account of spatial dispersion. The response of these systems to static fields has been widely studied in recent years and among others has given rise to the development of what is known as the modern theory of polarisation. The present project aims at the extension of those theories to the time-domain and will certainly have a big impact in the fields of condensed matter, material science, nano- and bioscience. The outcome of the project would be delivered to the whole scientific community as part of the Octopus project that aims to have a fully versatile free (GNU license) code able to describe the time-dependent electron-ion dynamics of finite and extended systems to arbitrary intense and time-dependent electromagnetic perturbations.The solution of the challenging theoretical problem addressed by the project requires combination of the expertise of the host in modeling electronic properties of matter and the strong background of the researcher in theoretical physics, materials science and computational methods. The know-how of the researcher in multi-level modeling and close collaboration with industry will help to raise the level of the host group in these areas. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bridging Academia and Enterprises for Innovative Mobility Solutions' under Horizon Europe.

assistant: **Concept**

The MobiNexus project aims to bridge the gap between academia and industry, catalyzing innovation in the transport and mobility sector through its focus on the triple revolution of electrification, automation, and digitalization. The project aligns with the European Green Deal and the Sustainable and Smart Mobility Strategy to reduce greenhouse gas emissions in the transport sector by 90% by 2050. By leveraging the Mobility Innovation Network (MIN) platform, MobiNexus seeks to integrate educational institutions with industry stakeholders, fostering collaboration and driving forward the development of sustainable mobility solutions. Key activities include the creation of innovation hubs, the use of AI-driven matchmaking for industry-academia partnerships, and the deployment of immersive workshops. Furthermore, the project emphasizes skill development through its User-Centric Entrepreneurship Academy, offering cutting-edge training in green, digital, and entrepreneurial areas, ensuring that the European transport sector remains competitive and environmentally sustainable. Ultimately, MobiNexus aims to foster interconnected innovation ecosystems across Europe, improving collaboration, innovation capacity, and market readiness in the mobility sector.


**Keywords:** user-centric innovation, collaboration , entrepreneurship
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Sub-seabed CO2 Storage: Impact on Marine Ecosystems (ECO2)'.

assistant: **Concept**

The ECO2 project sets out to assess the risks associated with the storage of CO2 below the seabed. Carbon Capture and Storage (CCS) is regarded as a key technology for the reduction of CO2 emissions from power plants and other sources at the European and international level. The EU will hence support a selected portfolio of demonstration projects to promote, at industrial scale, the implementation of CCS in Europe. Several of these projects aim to store CO2 below the seabed. However, little is known about the short-term and long-term impacts of CO2 storage on marine ecosystems even though CO2 has been stored sub-seabed in the North Sea (Sleipner) for over 13 years and for one year in the Barents Sea (Snøhvit). Against this background, the proposed ECO2 project will assess the likelihood of leakage and impact of leakage on marine ecosystems. In order to do so ECO2 will study a sub-seabed storage site in operation since 1996 (Sleipner, 90 m water depth), a recently opened site (Snøhvit, 2008, 330 m water depth), and a potential storage site located in the Polish sector of the Baltic Sea (B3 field site, 80 m water depth) covering the major geological settings to be used for the storage of CO2. Novel monitoring techniques will be applied to detect and quantify the fluxes of formation fluids, natural gas, and CO2 from storage sites and to develop appropriate and effective monitoring strategies. Field work at storage sites will be supported by modelling and laboratory experiments and complemented by process and monitoring studies at natural CO2 seeps that serve as analogues for potential CO2 leaks at storage sites. ECO2 will also investigate the perception of marine CCS in the public and develop effective means to disseminate the project results to stakeholders and policymake
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INEXPENSIVE AND RELIABLE ON-SITE SOLUTION FOR OLIVE PRODUCERS TO CONTAIN VERTICILLIUM WILT', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

VERTIGEEN addresses a need identified by olive sector SME-Associations for the rapid and reliable on-site detection and quantification of the Verticillium dahliae fungus in soil and plant samples. The increasing frequency and severity of this pathogen in most EU olive growing areas has made it the most serious problem of commercial olive plantations.For an estimated commercial price of €1,000/device and €10/test, VERTIGEEN will allow olive producers to reduce losses caused by this pathogen by means of precise and efficient field interventions within an Integrated Pest Management Strategy.The system innovatively integrates in a single platform new but successfully demonstrated technologies: the loop-mediated isothermal amplification (LAMP) method and the original in-solution-DNA electrochemical detection, overcoming the limitations of the state of the art in terms of heterogeneity, portability, price, ease of use and time-to-result.VERTIGEEN will directly benefit the European olive sector by limiting disease spread and reducing its impact. Crop yield and profitability will increase, while production costs related to the systemic use of pesticides and the production of healthy olive trees will be reduced. Other benefits extend to olive nurseries being able to issue quality certificates of planting material, and for authorities monitoring disease occurrence.The SME-AGs who have a direct role in the production and distribution of olive oil will benefit from direct economic benefits of their IPR ownership, while their associated SMEs will increase their profit margins, preserve employment and maintain a competitive edge in the global market.Industrial SMEs, chosen by SME-AGS to guarantee the best exploitation route to the market, will benefit from an innovative portfolio pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Role of Molecular Chaperones in Parkinson' s Disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Parkinson's disease is a severe human neurodegenerative disorder that affects mainly the aging generation. It is characterized by the loss of dopaminergic neurons from the substantia nigra, and the formation Lewy bodies, intraneuronal inclusions which are primarily composed of fibrillar alpha-synuclein. Several lines of evidence support a role for molecular chaperones as modulators of alpha-synuclein aggregation and toxicity in Parkinson's disease. Current findings suggest that prevention and/or the reversion of alpha-synuclein aggregation by molecular chaperones may constitute a promising therapeutic approach for the treatment of Parkinson’s disease and related disorders. However, the molecular and structural bases underlying the mechanisms by which molecular chaperones modulate protein aggregation and amyloid formation are yet poorly understood. The overall objective of this proposal is to gain a detailed mechanistic insight into the structural and molecular mechanisms by which molecular chaperones modulate protein aggregation and neurotoxicity in vitro using cellular models of synucleinopathies. We will focus on the functional relationship of the molecular chaperones Hsp70, Hsp40, Hsp90, and, Hsp27 that have been linked to Parkinson’s disease. In addition, we will assay the impact of Hsp104, which is the protein disaggregation machinery from yeast, on alpha-synuclein aggregation and toxicity. Thereby, we will seek to elucidate the molecular mechanisms by which molecular chaperones interact with alpha-synuclein and modulate its structural and aggregation properties in vitro, and we will probe the ability of molecular chaperones to prevent and/or rescue alpha-synuclein cytotoxicity in cellular models of synucleinopathies, including primary neuronal cell cultures. Such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Role of Metabolic INteractions in the Eco-evolutionary dynamics of bacteRial communities in the VAgina'.

assistant: **Concept**

Bacterial vaginosis (BV) is a polymicrobial syndrome that modifies vaginal secretions and increases risks of reproductive complications and most sexually transmissible infections. This syndrome is associated with a shift in vaginal microbiota composition from lactic-acid producing bacteria to specific bacterial communities. Concomitant with such shift, sialidases can be detected in vaginal secretions where they release sialic acids (SA), sugar molecules that some bacteria can use as a nutrient source and to escape host’s immunity. While the presence of sialidases is used as a BV diagnosis method, we still know little about SA metabolism in the species associated with BV, and even less about SA-related interactions in the community.The proposed project will directly address this question with the ultimate aim of understanding the role of SA metabolism in the transition from health to disease. I will focus my research on the three most prevalent BV-associated bacteria: Gardnerella vaginalis, Prevotella bivia and Atopobium vaginae. First, I will investigate the genomic organization and distribution of the genes involved in SA metabolism. Second, I will link these genotypes to phenotypes by experimentally assessing the expression of those genes in clinical samples from BV-positive and negative women. Third, I will assess the evolutionary stability of SA metabolism genes and bring insight into the respective roles of SA availability and host’s immune system in the evolution of bacterial SA metabolism. Finally, I will create ex-vivo minimal model communities of BV bacteria and examine the ecological interactions between species.By going beyond a taxonomic description to better understand eco-evolutionary functioning, this project will expand our view of the BV microbiome both
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evolutionary consequences of the norse expansion - a molecular perspective' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content  This project will examine the molecular genetic structure of selected peripheral populations of north western Europe, with the objective of identifying the genetic consequences of the Norse expansion over a thousand years ago. The primary aim will be to assess the relative contribution of ancestral Celtic and Norse populations to the contemporary gene pools of Iceland and the Outer Hebrides, and will investigate whether admixture or genetic drift played a more important role in shaping these gene pools. The study will also shed light on the genetic configuration of both the Celtic peoples that settled in the British Isles about three thousand years ago, and the Viking populations that inhabited the western and southern coasts of Norway during the Middle Ages. These aims will be carried out by a detailed analysis of mitochondrial DNA, Y-chromosome polymorphisms, and high resolution autosomal haplotypes in samples from populations living in Norway, mainland Scotland, Ireland, Iceland and Outer Hebrides Islands. Training content (objective, benefit and expected impact) Training in molecular DNA techniques that are essential in the study of human population genetics these include up-to-date DNA sequencing techniques including use of one automated sequencing machine, generation of microsatellite data that will involve multiplexed PCR and automated fragment analysis, detection of single site polymorphisms, and haplotype assignment. In Addition, considerable experience will be gained in the application of statistical methods to analyse sequence data and in the analysis of genetic diversity within and among populations, as well as testing hypotheses in human population genetics and human evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatial-temporal regulation of APC/C, its role on G1 arrest and impact on terminal differentiation' (STOPAPCG1IMP).

assistant: **Innovation**

Coupling the cell-autonomous process of the cell cycle with spatiotemporal clues that promote the differentiation process is a major challenge in developmental biology. The retina aberrant in pattern (rap) gene was initially identified as a retina differentiation and patterning gene in Drosophila. It was later discovered to encode Fizzy-related (Fzr), a coactivator of the cell cycle regulator, Anaphase Promoting Complex/Cyclosome (APC/C). This was a critical initial step towards establishing a link between differentiation and cell cycle regulation. This project aims to understand the coordination between mechanisms of proliferation and differentiation, with a particular focus on the APC/C complex. The requirement of individual APC/C components to sustain the developmentally controlled G1 arrest and its subsequent effects on terminal differentiation will be addressed. The transcriptional and posttranslational regulation of each APC/C component will be assayed during eye development. Next, functional APC/C interactors will be identified through two complementary screens. An in vivo gain-of-function overexpresion screen will be performed, to identify the genes that can induce cell cycle arrest in overproliferating tissues, using the newly developed FlyORF library. Additionally, a proteomic analysis of APC/C components will be performed to identify eye-specific APC/C interactors. With the information gained I will investigate how the activity and expression of the APC/C is spatial-temporally controlled by signalling cascades during eye development, and how the APC/C in turn modulates the activation and output of those signalling pathways. Overall, the insights from this project will contribute to our understanding of complex diseases such as cancer and neurodegeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'World Energy Technology Outlook - 2050 (WETO-H2)' (WETO-H2) under Sixth Framework.

assistant: **Objectives**

This proposal is a co-ordination action whose final objective is to produce the pre-print of a reference book presenting a world energy/technology outlook by 2050. In addition to the elaboration of the long-term baseline projections, the proposed project will also assess various technological breakthroughs likely to occur in the next 50 years in a context of a high value of the carbon, and evaluate two European strategies toward sustainability: the first one towards an hydrogen economy for Europe, the second one towards a reduction by a factor 4 of the CO2 emissions related to energy. The co-ordination action is based on the exploitation of the POLES model which is a global sectoral model of the world energy system, and of mean-variance portfolio optimisation to assess EU-25 energy electricity mixes/scenarios as produced by the POLES model for their financial risk-reward" efficiency .The work plan proposed is broken down into five Work Packages  (WP):"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Direct remote C-H functionalization in piperidine derivatives' to be submitted under Horizon 2020.

assistant: **Abstract**

The transition metal-catalyzed direct functionalization of C-H bonds is a major research topic across the world. However selective (regio-, enantio-, diastereoselective) and efficient functionalization of C(sp3)-H bonds, remains a significant challenge: C(sp3)-H bonds are omnipresent in organic molecules and their dissociation energies are large. The use of directing groups (DGs) “guiding” the metal to specific C-H bonds and allowing intramolecular C-H bond activation, is a recognized general approach to address the selectivity challenge. However, their installation and removal add steps to the overall reaction sequence. This proposal aims to develop unprecedented regio- and diastereoselective transition metal-catalyzed functionalization of piperidine derivatives with haloalkenes making use of transient DGs, installed and removed in situ during catalysis. Access to a large number of substituted piperidines as well as known and new bicyclic scaffolds can be achieved via post-functionalization of the vinylpiperidine reaction products, making the aimed synthetic methodology potentially suitable for molecular library synthesis in drug discovery. A particularly challenging objective of the proposal is the remote (meta) functionalization with respect to the DG at C3 of the piperidine ring. Piperidine is chosen as a central heterocycle core in this application based on its importance in drug design and wide occurrence in commercial drugs (privileged scaffold).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Facilities for testing orbital and surface robotics building blocks' (FACILITATORS).

assistant: **Innovation**

The FACILITATORS goals are:-To Enable the highest possible level of validation of the common building blocks (developed by concurring operational grants) in the most relevant environment by adapting and providing the best available European test facilities, as well as -To Guarantee coherence among the different test facilities and among the building blocks by establishing common implementation/validation scenarios (to be reproduced during ground testing) and common interfaces with the test facilities.More concretely, in order to achieve such goals, the objectives of our project are to:1. Analyse and identify the validation needs of each building block2. Identify and adapt the already-existing top-notch European test platforms that will form a “federation of facilities” which will host the validation tests of ALL building blocks in BOTH demonstration scenarios3. Characterize the facilities and provide representative datasets to support the design and development of the building blocks, carried out by concurring operational grants (OGs)4. Ensure coherence among the different building blocks by agreeing on common demonstration scenarios that will be carried out within the federation of facilities, as well as by preparing common interfaces in coordination with the SRC board and the other parallel OGs5. Provide easy access to the identified facilities, and ensure their availability when the building blocks will be tested6. Assist the building blocks validation tests’ execution by providing monitoring and measuring means, as well as giving on-site support.The “Federation of Facilities” concept lies in a network of coordinated, complementary and exchangeable state-of-the-art facilities across Europe, identified, made available to the SRC, adapted and (if needed) enhanced for t