RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Extracellular vesicle production and engineering by turbulence for fistula therapy in thermoreversible hydrogels' (ExocyTher), addressing dissemination and exploitation.

assistant: **Impact**

Extracellular vesicles (EVs) from stem cells (SCs) may recapitulate the therapeutic effect of their mother cells in regenerative medicine while mitigating risks of uncontrolled replication, differentiation and vascular occlusion, offering off-the-shelf, storage and shelf-life gains. Yet, the clinical translation of SC EV therapy is hampered by production, engineering and administration challenges. Building on my preliminary results, ExocyTher aims at developing SC EV therapy through:(1) standardized scalable high-yield EV production: I propose the concept of turbulence vesiculation to induce EV release from adipose SCs (ASCs) by a controlled turbulence shear stress integrated to large-scale cell culture in bioreactors; (2) optimised delivery: I propose EV administration in a synergic fistula-occlusive companion gel (injectable at <20C and gelling at body temperature) in the attempt to fill the entire fistula tract and retain EVs at the site of interest; ExocyTher will tackle the therapy of fistulas, a major health burden related to Crohn's disease or secondary to surgery, cancer therapy or trauma, affecting millions of people in Europe with a high morbidity rate. All-in-one turbulence-triggered vesiculation and priming are expected to provide ASC EVs in high yield and with improved immunomodulatory properties specially for a more efficient therapy of inflammatory Crohns disease fistulas. Capitalizing on the use of a gel medical device authorized in Europe as an off-label fistula occlusive EV vehicle and considering key regulatory issues, ExocyTher will set the basis for the first clinical trial on ASC EV fistula therapy.ExocyTher concepts may be extended to other EV parent cell types or therapy indications, foreseeing a high scientific and technological impact.Start dat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Feasibility Pilot Study for the Development of an Inherent Safety Opportunity Audit/Technology Options Analysis' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The purpose of this research is to investigate the feasibility of developing an inherent safety opportunity audit/technology options analysis to encourage the adoption of primary prevention approaches.It is now generally recognised that in order to make significant advances in accident prevention, the focus of industrial firms must shift from assessing the risks of existing production and manufacturing systems to technological alternatives, i.e. from the identification of problems to the identification of solutions. The underlying premise of this proposed research is that encouraging the industrial firm to perform technology options analysis (TOA) and to consider technological changes through an inherent safety opportunity audit would facilitate the advance of primary prevention strategies that will alter production systems so that there are less inherent risks. Inherent safety approaches also have managerial advantages over secondary accident prevention: they fit more easily with proactive policies, and facilitate organizational learning processes that are vital for the continuous improvement in safety and environmental performance that is needed for a sustainable development. A Technology Options Analysis (TOA) should form the centrepiece of an Inherent Safety Opportunity Audit (ISOA). This approach enables the industrial firm to identify and consider changes and alternatives to their present production technologies and approaches. This includes inputs, final production and process changes involving alternative synthetic pathways. This project concerns the development of such a Technological Options Analysis (TOA) as part of an Inherent Safety Opportunity Audit (ISOA), the realization of four pilot projects in relevant companies (2 in The Netherlands, 2 in Greece), th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Complex Exciton Dynamics in Materials: a First-Principles Computational Approach' (CompExDyn).

assistant: **Concept**

Understanding the energetics and dynamics of excited states formed by light-matter interactions is essential for applications across optoelectronics and photophysics. In systems of reduced dimensionality, strongly-bound excitons serve as the main energy carriers, with long diffusion and relaxation lifetimes. As exciton dynamics are coupled to optical selection rules that stem from the atomic structure, enhanced exciton transport efficiency can be achieved through local structural modifications, such as atomic impurities and interface design, as well as crystal fluctuations. Yet current theories lack a predictive description of the underlying interactions due to such structural modifications, highlighting the need for new tools that can capture these complex exciton dynamics.Taking advantage of ever-growing computational frontiers, in this ERC project, we will derive and apply a new theoretical approach, based on the predictive many-body perturbation theory, to compute exciton dynamics as a function of structural complexity in emerging materials. We will derive and examine our approach on three emerging excitonic systems of reduced dimensionality: organic molecular crystals, layered transition metal dichalcogenides, and two-dimensional hybrid perovskites [Obj.I]. As proof-of-concept, we will use our theory to study the effect of atomic defects and heterostructure compositions [Obj.II], as well as lattice fluctuations [Obj.III], on the mechanisms dominating exciton relaxation and diffusion and their resulting mobility and lifetime.Our research will thus allow for a comprehensive and predictive understanding of the underlying physics dominating exciton decay processes in materials of emerging interest via front-line computations, offering novel and tunable design principle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Small RNA Mediated Epigenetics in Vertebrates' to be submitted under Seventh Framework.

assistant: **Abstract**

Since the discovery of RNAi small RNA molecules have been under intense study. They have been shown to impact many different processes, ranging from development to organ function and carcinogenesis. Recently, it has become clear that many distinct small RNA families exist. However, all act through a member of the well-conserved Argonaute family of proteins. I try to understand how specificity of the different Argonaute proteins is achieved, and I am particularly interested in Argonautes that may contribute to the epigenetic marking of genomic DNA in animals. My focus is on Argonaute function in the vertebrate germline, a tissue that is an especially intriguing system with regard to the resetting and establishment of epigenetic marks. As model system I use the zebrafish. Piwi proteins are Argonaute proteins that in vertebrates are specifically expressed in germ cells, and have been implicated in modifying chromatin structures. We demonstrated that zebrafish piwi is expressed in both the male and the female gonad and that loss of piwi results in loss of germ cells due to apoptosis. We have characterized small RNAs that bind to piwi (piRNAs) in both ovary and testis, and found that they play a role in the silencing of transposable elements. Furthermore, we have shown that the biogenesis of piRNAs differs markedly from that of other small RNAs like miRNAs. The experiments I propose address how Piwi proteins and piRNAs act in germ cells to ensure a functional germline and a stable propagation of intact chromatin over generations. First, I will address the biogenesis of piRNAs. Second, I will identify novel components of the Piwi pathway. Third, I will address the mode(s) of action of piRNAs. On all fronts a combination of genetics, molecular biology and biochemistry will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of retrotransposition in humans and consequences on cancer genomic plasticity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Retrotransposons are a class of highly repetitive sequences, which are very abundant in the human genome. They disperse by an RNA-based copy-and-paste mechanism, called retrotransposition. This process can drive profound genome rearrangements. Although generally silent, they are expressed in germ cells, in the early embryo, and in embryonic stem cells, which occasionally results in genetic diseases. Retrotransposons are also massively re-expressed in the large majority of cancers, but the importance and consequences of retrotransposition in human tumors have been poorly studied. Somatic retrotransposition is difficult to track in human tissue due to the highly repetitive and dispersed nature of these elements. Thus the questions we wish to address in this research proposal are the following: (i) What cellular pathways control retrotransposon copy number? This will be achieved by combining functional genomics and proteomics approaches to identify positive and negative regulators of retrotransposition in humans. (ii) What are the molecular mechanisms of retrotransposons replication? To answer this question, we will develop a cell-free assay that will contain the complete retrotransposition machinery. (iii) How retrotransposons participate in the normal and pathological remodeling of the human genome? To this purpose we are currently developing innovative approaches to track retrotransposition events in clinical samples, especially in tumor samples. Since LINE-1 elements (L1) are the most active and autonomous retroelements in our genome, we focus, at the moment, our investigations on this family. Understanding how the activity of retrotransposons is controlled will impact our knowledge of the mechanisms that lead to new genetic diseases or to cancer progression. Since mob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Effortlessly Diagnosing Sleep Apnea with the Sensa Platform' (Sensa) under Horizon 2020.

assistant: **Objectives**

12% of adults suffer from obstructive sleep apnea (OSA). Despite the fact that it is a serious disease, it goes undiagnosed 80% of the time. The cost of undiagnosed OSA patients is €6,000 per person per year whilst the cost of diagnosed patients is only €2,000 per person per year. Multiplying by around €4,000 that could be saved per diagnosed person, the total savings would be €160 billion/year.Very effective treatment options exist, but the traditional diagnostic infrastructure is neither affordable nor scalable to diagnose this vast number of unidentified sufferers. To this day, the polysomnography is the gold-standard for diagnosing OSA. However, this method is expensive, time-consuming and cannot keep pace with the huge demand.Neoma Labs has developed Sensa: a cost-effective, miniaturized and connected device that has the potential to become the new gold-standard in OSA diagnostic. The unique approach is measuring mandibular movements to assess OSA. The Sensa solution adds a qualitative layer to the quantitative measures, providing consumers with a sense of control over their health-life balance.The OSA diagnostics market is driven by a growing awareness regarding the ill effects of untreated sleep apnea, a large pool of undiagnosed OSA patients as well as emerging technologies. Regarding our revenue model, we are considering a pay-per-use model at €50/screening.With its simplicity and high clinical validation, Sensa will be able to help lower the 80% of OSA patients who go undiagnosed, thereby reducing the costs/burden associated with the disease. With around 408 million adults in the EU, this would mean 49 million people suffer from sleep apnea and 40 million never get diagnosed.Neoma Labs was founded in June 2015 by a team of experts with professional experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cryptogam biodiversity dynamics under climate change in the Arctic and Antarctic poles' to be submitted under Horizon Europe.

assistant: **Abstract**

Earth’s polar regions are warming at unprecedented rates. Antarctica is experiencing rapid regional warming, and the Arctic has warmed up to four times the global average. In response, vascular plants have experienced shifts in species’ abundance and distribution. Polar regions host large richness of cryptogam species (bryophytes and lichens), which are essential ecosystem regulators that contribute to nutrient cycling, soil moisture and energy balance. Despite these crucial roles and expectations that cryptogams can be seriously affected by climate change, taxonomical challenges hinder our understanding of their current trends. BIPOLAR will tackle this knowledge gap by quantifying polar cryptogams’ climatic niches to understand their potential for climate change adaptation. Both poles contain similar habitats shaped by extreme conditions, but the Arctic is warming more rapidly than Antarctica, and ecological processes have been more extensively documented there. BIPOLAR is an interdisciplinary project that will provide a window into the future of Antarctic cryptogams by using the Arctic as a sentinel region via bipolar cryptogam species (i.e., present at the two poles). BIPOLAR will combine a variety of methods and data (i.e., palaeoecology, open-access datasets, fieldwork and Bayesian statistics), and employ historical and current data to inform future projections. The three objectives of BIPOLAR are: 1) Compiling and standardising bipolar cryptogam data from multiple sources, 2) Quantifying past, present and future macro- and micro-climatic niches, and identifying winner and loser cryptogam species, and 3) Validating species occurrence and climate data through fieldwork. This research will provide a foundation for conservation as these regions become progressively mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'LOW COST PENSTOCK DAM AND TURBINE CONSTRUCTION OF OPTIMUM USE OF STORAGE AT TAWNAWULLY, BARNESMORE, CO DONEGAL'.

assistant: **Concept**

To demonstrate the use of low cost penstock material construction, low cost intake/dam construction, low cost turbine construction and incorporate automatic break which eliminates the need for quick shutoff, cellular telephone control system to operate remote valve water which can be used to improve the output of, existing installations, harnessing hydro power and improving the river amenity by providing a new lake and fish passes.The project has a number of innovations :* The dam will be a stone faced earth filled construction using local site materials, reducing cost and blending with the natural surroundings.The low pressure penstock will be constructed in the most part from low cost reinforced concrete pipes compared to more costly P.E., Ductile iron or steel pipes. The pipeline will incorporate a syphon effect to overcome negative falls without costly excavation in rock during construction. The high pressure pipeline will be constructed from prestressed concrete pipes. The inclusion of a surge tank slow closure valve system allows this material to be utilised with a Francis turbine which would not be possible otherwise due to waterhammer.Remote control valves will be used to provide secondary storage at two outlaying loughs. These will be operated via a cellular telephone system.The turbine will have a runaway speed of 1,350 rev/min for 24 hours facilitating slow closure of isolating valves.The intake construction will have an automatic cleaning device and low cost automatic bleed. This controls the amount of bypass water and at the same time ensures a good flushing action on a regular basis. The detailed design and construction ensures a relatively low cost good suction depth for the penstock pipeline.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SEVERE ACUTE RESPIRATORY SYNDROME (SARS): DESIGN, SYNTHESIS, IDENTIFICATION, AND EVALUATION OF NOVEL NON-PEPTIDIC INHIBITORS OF MAIN PROTEASE EMPLOYING DYNAMIC LIGATION SCREENING (DLS)' (SARS).

assistant: **Concept**

The Severe Acute Respiratory Syndrome (SARS) emerged in 2003 in Asia, and within a few months infected 8500 people world and caused more than 800 deaths. This novel medical condition is a viral respiratory illness caused by the SARS-associated coronavirus (SARS-CoV). And at present, no efficacious therapy is available, for these reason finding a useful drug candidate against SARS corona virus is a goal with high scientific, technological and socio-economic interest. Our (and other´s) preliminary results indicate that the viral protease is an excellent target for the treatment of coronaviral infections. In order to obtain new active SARS-CoV molecules as main protease inhibitors Dynamic Ligation Screenig (DLS) methodology will be developed. This new approach combines dynamic, target-assisted formation of inhibitory species and detection by fluorescence-based screening methodology. In addition to use an enzymatic reaction for fragment detection amplifies the signals and thus reduces the required amount of protein drastically. Finally, enzymatic detection via a fluorescent reporter molecule should enable high-throughput screening (HTS) in microtiter plates. Based on preliminary results, the synthesis of structural analogues of peptide-aldehydes, that containing in the C-terminal extreme other functionalities, will be synthesized. The reaction of these analogues of peptide-aldehydes, acting as directing probe, with a library of amines, carboxylic acid and isocyanides in presence of the enzyme, their substrate in water through Mannich and Ugi reactions provides -amino carbonyl and -N-acylamino amides compounds. The analysis of the crude reaction mixtures will be carried out employing fluorescence assay and it will be allowed us find active fragments (Hits). In these cases,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neural circuits for space representation in the mammalian cortex' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Neuroscience is one of the fastest-developing areas of science, but it is fair to say that we are still far from understanding how the brain produces subjective experience. For example, simple questions about the origin of thought, imagination, social interaction, or feelings lack even rudimentary answers. We have learnt much about the workings of individual cells and synapses, but psychological phenomena cannot be understood only at this level. These phenomena all emerge from interactions between large numbers of diverse cells in intermingled neural circuits. A major obstacle has been the absence of concepts and tools for investigating neural computation at the circuit level. The aim of this proposal is to combine new transgenic methods for cell type-specific intervention with large-scale multisite single-cell recording to determine how a basic cognitive function   self-localization   is generated in a functionally well-described mammalian neural circuit. We shall use our recent discovery of entorhinal grid cells as an access ramp. Grid cells fire only when the animal moves through certain locations. For each cell, these locations define a periodic triangular array spanning the whole environment. Grid cells co-exist with other entorhinal cell types encoding head direction, geometric borders, or conjunctions of features. This network is thought to form an essential part of the brain s coordinate system for metric navigation but the detailed wiring, the mechanism of grid formation, and the function of each morphological and functional cell type all remain to be determined. We shall address these open questions by measuring how dynamic spatial representation is affected by transgene-induced activation or inactivation of the individual components of the circuit. The endeav