RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Micro-tumor Guided Cancer Therapy Selection MicroCaT'.

assistant: **Objectives**

Every year around 350.000 patients in the EU are newly diagnosed with colorectal cancer (CRC). Although € 1.4 Billion are spent on CRC drugs, the majority of patients fail to respond to therapy because their individual tumor is resistant to the chosen treatment. These patients suffer from unwanted side effects and after two month are switched to another drug regime – giving rise to additional drug and hospital costs.  2cureX ApS, a Danish SME, has developed IndiTreat, an ex-vivo chemosensitivity test. The functional profiling test uses 3D-cellular “micro-tumors” prepared directly from a patient’s tumor. It allows the selection of the most effective and least toxic drug regimen for each individual patient prior to initiating treatment. For the oncologists and patients this greatly improves the probability of selecting an effective drug treatment.   The main objective of MicroCaT is to clinically validate the benefits of IndiTreat in an interventional multi-national study with metastatic (stage IV) colorectal cancer patients. Demonstrating the clinical utility and cost effectiveness of IndiTreat will pave the way for uptake in EU clinical guidelines and reimbursement arrangements. Communication and dissemination of MicroCaT project activities will be key to raise the consciousness of this breakthrough innovation with clinicians, patients and health assessment authorities. Commercializing IndiTreat for CRC patients will enable 2cureX to significantly grow and expand its business. With the potential to predict therapy responses in all solid forms of cancer, the use of IndiTreat will eventually result in multi-millions of health care costs savings as well as improving the quality of life of cancer patients across Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'iPURXL: Scale-Up of Liquid Nano-reactor for the Destruction of Contaminants in Turbid Fluids' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The iPURtech Nanoreactor effluent fluid treatment system recycles metal working fluids in an almost closed loop.  iPURXL builds on 2 years successful sales and a growing list of enquiries to transfer the technology to other sectors, particularly for the treatment of water and other aqueous liquids.  This will required scale up from our current >20-50 Litres per hour systems to those capable of processing >1000 in line with customer demand.  This will enable us to sell into both single line and  full site effluent treatment, ranging from small meat rendering plants up to full scale municipal waste water treatment.The original system treats fluid in quartz tubes supplied with sufficient UV-C light to operate.  A TiO2 photo-catalyst coated auger causes oscillation and scrubs tube walls clean.  Conventional systems immerse single lamps in fluid; we use multiple high powered UV-C lamps around tubes to achieve higher volume kill ratios making iPURtech uniquely suitable for scale up.TiO2 reactors are well researched yet little large scale commercial delivery has resulted.  To succeed commercially this must be practical.  Direct linear scale up is not possible, issues such as coating light weight auger materials over greater surface areas, UV dose, system size and weight and must be addressed.    Over summer of 2014, testing was carried out with a range of meat renderers and with the input of a range of technical and commercial specialists.  This has resulted in the development of a very strong research, development, supply and sales team and we are confident of our combined abilities to deliver at commercial scale immediately post this demonstration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pharmacophore guided diversity-oriented synthesis and its application in discovering inhibitors of protein-protein interactions between RAD51 and BRCA2' (Pharmcophore-DOS), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research aims at discovering inhibitors of protein-protein interaction (PPI) between RAD51 and BRCA2 as a promising treatment of cancer, in particular to reverse the resistance of cancer cells to radiotherapy and cytotoxic chemotherapy. The pharmacophore guided DOS approach developed in this project has the potential to be a general method for rational discovery of PPI modulators. The researcher will acquire novel technologies and develop new skills in both scientific and management aspects, which are important in his professional maturity and career plans; while the host can also be benefitted from his experience in medicinal chemistry. This action will promote the mobility inside the European Research Area and spark lasting cooperation among different European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Potential impact of sea level rise related salinization on lowland tropical coastal peatlands'.

assistant: **Concept**

Sea level rise (SLR) poses risks of flooding and salinization to coastal ecosystems. At present, research on SLR impacts still heavily focuses on saline ecosystems (e.g., mangroves, saltmarshes), despite the impact of salinization being particularly dire for freshwater ecosystems. Southeast (SE) Asian coastal peatlands are freshwater wetlands playing important role in tackling the triple planetary crisis: climate change, biodiversity loss and pollution. Mainly located in low-lying coastal plains, SE Asian peatlands are highly vulnerable to the impacts of SLR. My recent research indicates that SLR-induced salinization could lead to catastrophic fires by promoting mass peat swamp forest mortality, thus increasing dead fuel availability. However, SLR impacts on SE Asian peatland ecosystem structure and functioning remain severely understudied to date. The SaLtedPeat project aims to pioneer the timely exploration of the impacts of SLR, particularly salinization, on coastal forested peatlands of SE Asia. Within this project, my team and I will explore the historical relation between SLR and severe fire occurrences in SE Asian coastal peatlands using long-term ecological studies as well as analyse the contemporary land-sea gradients in peatlands through field observations. We will mimic the impact of SLR-related salinization on peatland vegetation and peat physicochemical properties by performing a salt-addition experiment, and model changes in peatland properties and C stocks following SLR and projected precipitation changes. The SaLtedPeat project will unravel the potential (hidden) impacts of SLR on SE Asian peatlands, provide the first assessments of salinity (in)tolerance of peat swamp forests, advance knowledge on the ecosystems’ spatiotemporal variability, and estimate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Efficient Composite parts manufacturing' (EFFICOMP) targeting Horizon 2020.

assistant: **Abstract**

The main objectives are to propose R&D activity to reduce cost and increase ramp up production of composite parts for structural application on aerospace products. These objectives are fully in line with objectives of the call MG1.8. European partners consortium is composed with end user (AIRBUS Group) and research laboratories (DLR, Stuttgart University, Delft University) and a dissemination expert partner (EASN). All selected partners have a strong experience with aerospace research activity. To fulfill the proposal objectives, the main technical topics that will be addressed are new low cost materials, new efficient heating concepts for composite curing, new forming process for large and thick parts, new low cost assembly processes, new environment around the mold (reusable bagging, reusable de-molding agent) and out of autoclave manufacturing concepts. Certification cost reduction for new issues such as sparking characterization during lightning strike impact will also be addressed. As one of the key points of this project is to propose new low cost concepts for composite part production, a specific workpackage will be dedicated to cost analysis of developed solutions and comparison with existing state of the art cost of composite parts.  Most promising results will be integrated in a composite validation elements produced by the partners to give more credibility to the results. To get the maximum outputs from this project, the activity is distributed between different partners according to their expertise on the topic they will address.  We have an important result exchange phase during the validation element definition and manufacturing activity. Globally for the developed technologies a TRL between 4 and 5 is foreseen at the end of EFFICOMP project.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a new generation of CIGS-based solar cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main objective of NanoCIS is the establishment of a cooperative partnership between research organizations through a joint program of exchange of researchers for developing a new generation of photovoltaic (PV) solar cells. This new generation of PV solar cells will be based in approaches involving the use of new materials with high conversion efficiencies and low-cost fabrication techniques.The broad aim is the theoretical and experimental design, synthesis and characterization of new advanced materials, based on chalcopyrites absorbers, allowing the manufacture of an intermediate band solar cell.  New concepts such as Intermediate band and luminescent materials for further development of CIGS solar cells are going to be investigated. This new class of materials has been predicted theoretically as potential candidates for providing very high efficiency (63%) in solar energy conversion. According to present knowledge, this compounds based on chalcogenide-type semiconductors are quite novel as general materials, especially in their application to solar energy.Electrodeposition (ED) is the technique chosen for developing such approaches. ED is essentially a non-vacuum approach to fabricate high quality thin-film materials for PV modules that could lower the manufacturing costs by over 50% and increase the PV module efficiencies. The ED technique offers the most attractive range of benefits leading to the low cost fabrication of PV cells, such as high rate of deposition, high resolution, high shape fidelity, self purification, scalability and good compatibility with existing processes. ED adds another cost effective step in low-cost solar cell because the transparent conducting oxide layers (TCO) can be deposited by the same method. The use of inline processing through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Blending biophysical and drug discovery platforms to investigate allosterism in G-protein-coupled receptors (GPCRs) and find novel allosteric modulators for neurotherapeutics development' (GPCRs).

assistant: **Concept**

The global socio-economic and health burden of neurological and neurodegenerative diseases is enormous, impacting overall quality of life and overwhelming available resources. The situation is worrying, considering the predicted future explosion in the aging population. There are currently no ideal drugs to manage these debilitating conditions. This project will thus achieve two major aims:1. Use biophysical approaches to improve fidelity of pharmacological observations of ligand-receptor interactions for determining mechanisms of action. This will allow investigations of such interactions at the single-cell level, as opposed to current investigations in cell populations, which are less accurate.2. Use the platform in aim 1 to develop screening assays to identify allosteric modulators of three receptors of exceptional clinical significance: adenosine, metabotropic and GABAB receptors. Allosteric modulators bind to a site on the receptor different from where the endogenous ligand binds, with better selectivity and reduced incidence of side effects compared to orthosteric modulators that bind to the same place as the endogenous ligand.The inter- and multi-disciplinary project combines pharmacology, biochemistry, molecular and cell biology, medicinal and synthetic chemistry, drug discovery and biophysics. It is intersectoral, featuring collaboration with a spin-out company (CellAura). Allosteric modulators would be developed as pharmacological tools or novel drugs in an arrangement that creates opportunities for longer-term collaboration with the USA, especially Johns Hopkins University.The Fellow will bring unique expertise in drug discovery and neuroscience. He will enhance his career prospect by engaging in a novel project different in focus and approach from what he un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Persuasive Advisor for CO2-reducing cross-modal Trip Planning (Peacox)' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ecological issues in traffic become more and more pressing as personal transportation is one of the greatest contributors of CO2 emissions. Means to help people reducing their ecological impact are urgently needed. To answer this need Peacox provides travellers with personalized multi-modal navigation tools that allow, help and persuade them to travel and drive ecological friendlier. To convince users in making more sustainable travel choices Peacox will enrich navigation systems with innovative approaches and features:\tPeacox integrates automated travel mode detection based on real-time GPS data into the trip planning thereby minimizing the need for explicit user input.\tPeacox has the capability to automatically detect users' trip purpose through the analysis of behavioural patterns allowing tailoring trip suggestions to these purposes.\tPeacox builds dynamic user models allowing personalizing recommendations based on prior trip choices and individual preferences.\tPeacox develops advanced door-to-door emissions models that provide accurate feedback on the ecological/carbon footprint and exposure levels in planning as well as during travelling and car driving activities.\tPeacox develops and utilizes persuasive interface strategies to give feedback about the ecological impact of individuals' behavior as well as make the ecological friendliest behavioral pattern visible and attractive.The system will be developed in two iterations following user-centred and agile design approaches, and extensive field trials in Vienna and Dublin will ensure high quality and impact of the developed Peacox system. The Peacox consortium unites expertise from navigation systems, transportation sciences, environmental modelling, artificial intelligence, persuasive technology, human-co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cloud-Phase Feedback and Climate: bridging the gap between observation and simulation'.

assistant: **Concept**

Earth’s climate is rapidly changing, with major socioeconomic consequences. A key scientific challenge is to improve climate-model projections by reducing uncertainty in cloud-climate feedbacks. The proposed research will investigate a cloud-feedback mechanism that has a potentially powerful but highly uncertain effect on global climate change. The feedback involves a conversion of ice cloud to liquid cloud that is caused by a warming atmosphere. Our goal is to attain the first quantitative estimate of this feedback based on satellite observations and to develop climate-model software that enables a direct model-to-observation comparison of the feedback. This will close gaps between observational and modeling studies of cloud feedbacks, and it will provide a clear benchmark for assessing climate projections.This fellowship will be carried out in the Department of Geosciences at the University of Oslo under the supervision of Prof. Trude Storelvmo. The research will leverage my expertise in satellite observations and that of the host in climate modeling, thus facilitating a two-way transfer of knowledge. I will gain several new experiences during the fellowship, including working in an interdisciplinary research group, studying in Europe, co-advising graduate students, and engaging with different outlets for public communication. The skills, knowledge, and international network that I will develop will put me in an excellent position to achieve my long-term goal of leading a research group.


**Keywords:** cloud-climate feedbacks, mixed-phase clouds, climate sensitivity, global climate modeling, radiative transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'One-Dimensional Wide-Bandgap Semiconductor Nanostructures:  Analysis and Applications' (NANOWIRES) under Seventh Framework.

assistant: **Objectives**

Research and development in nanotechnology has seen an astonishing progress during the past decade, and has now provided clearer indication of its potential. There is great potential to incorporate nanotechnology-enabled products and services into almost all industrial sectors and medical fields by 2020. Resulting benefits will include increased productivity, more sustainable development, and new jobs.  To advance our scientific knowledge, and to bring competitive advantage to the EU research and development in nanotechnology, PI proposes to investigate silicon carbide (SiC) and aluminum nitride (AlN) wide-bandgap semiconductor nanostructures and develop new applications of these nanostructures for energy generation, optoelectronics,  and sensing. The proposed project is aimed not only to address the fundamental technical and scientific issues of 1D nanostructures, but also develop original products utilizing these materials.  1D-AlN nanostructures are extremely important for many applications in several fields including power transistors, optoelectronics, heat sinks, resonators, sensors, and nanogenerators. Similarly, due to its inherent superior properties, SiC is an excellent material for applications in many areas including microelectronics (high temperature, high power, and high frequency), thermoelectrics, optoelectronics, and biomedical.The specific research objectives are: 1) Full spectrum characterization of AlN nanostructures; 2) Development of AlN nanostructure based electricity generators (nanogenerators); 3) Full spectrum characterization of SiC nanowires; 4) Fabrication of SiC-nanowire devices for studying electrical, photoconductivity, and thermoelectric properties of the SiC nanowires.The proposed project will significantly contribute to Europe’s competi