RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Small RNA toxicity and DNA damage response in Huntington´s disease' in the context of a Seventh Framework call.

assistant: **Objectives**

Huntington´s disease (HD) is an incurable and fatal neurodegenerative disease, manifested by a progressive loss of neurons, causing neuronal motor dysfunction, cognitive decline and death. The disease is caused by a CAG repeat expansion in the Huntingtin (HTT) gene. The CAG expansion induces a neurotoxic effect, mainly thought to be caused by the expanded protein. However, also expanded RNA transcripts can cause toxicity by generation of small CAG-repeated RNAs. Generation of these small RNAs depends on Dicer ribonuclease activity and their toxic effects are modulated by Ago proteins. This links RNA toxicity with the RNA interference (RNAi) pathway, suggesting abnormal induction of gene silencing through small-repeated RNAs.The DNA damage response (DDR) plays a role in HD pathogenesis as well. Recently, it was shown that small RNAs derived from Dicer and Drosha processing can induce and control this response. The goal of this project is to address the possible link between small CAG-repeated RNA toxicity and the DDR pathway in HD.We hypothesize that small RNAs activate a DDR response and thereby induce neurotoxicity. We will address this by the following objectives: 1) Establish whether CAG-repeated RNAs activate the DDR pathway, 2) Establish whether DDR inhibition can modulate small RNA toxicity and whether DDR activation is RNAi pathway dependent, 3) Validation of our results using in vivo and ex vivo samples. We will use in vitro cell models combined with ex vivo brain samples from HD affected mice and humans. The effect of small CAG-repeated RNAs on activation of the DDR response will be analyzed by western blot, immuno-fluorescence and immuno-histochemistry. Small RNA pool analysis, knockdown studies and lentiviral transfection approaches will be used to reveal the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An advanced biological remedy against jellyfish stings' (2014-2020).

assistant: **Concept**

In recent years anomalous proliferations of jellyfish are increasing in all seas: human envenomation by jellyfish toxins produce immediate toxicity (from minutes to few hours), with allergic responses, generally determining local symptoms (dermatitis, oedema and swelling, itching, stiffness, necrosis, pain) or more severe systemic effects. These can also be life threatening and, sometimes, bring to death.It has been estimated there are 150 million jellyfish stings a year, about 200,000 people are annually stung by jellyfish in the only Florida. $350 million in losses to the Black Sea’s fishing and tourism industries resulted from the invasion of the comb jelly into the Black Sea. Therefore, beyond a public health issue, jellyfish also constitute a threat to tourism.Sea anemones can kill other fish that touch them; clownfish is therefore immune to the poison, thanks to generation of a biomimetic film on the fish skin. Toxins in the different types of Cnidarian (e.g. medusa and anemones) are similar, as they developed from common ancestors and belong to the same lineage.The project SOSJelly intends to evaluate the feasibility of the development, manufacturing method, technological transfer and industrial scale-up and to third parties manufacturers, and licensing for commercialization of a completely new biosynthetic molecule or mix of molecules, with bio-mimetic properties, for the first time, able to protect human skin from the jellyfish contact effects. Furthermore, ABICH laboratory will formulate creams and gel without preservatives at all, suitable for allergic people. At the end of the Phase I, a pre-commercial advanced SOS Jelly “package” (ingredient, formulation, laboratory test, regulation compliance, etc.) will be offered to manufacturers of sunscreen products.Ta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Building a European Network of Academic Mentoring Programmes for Women Scientists'.

assistant: **Concept**

Proposal abstract The project aims at strengthening the position of women scientists in academia and leading and decision-making positions, through the instrument of mentoring, by building up a network of Mentoring programmes supporting junior women scientists from various regions in the wider Europe, through the:A. Exchange, among mentoring programmes, of experience and best practices in setting up and implementing mentoring programmes for high potential junior women scientists at local, regional and cross-national/transnational levels, and knowledge transfer at a wider European level;B. Definition of means and long-lasting structures of cooperation among mentoring programmes for high potential junior women scientists on a wider European level;C. Strengthening women's impact on science decision-making and policy definition through mentoring and definition of standards for academic women scientists' support, by exchange of experiences and networking;D. Dissemination of best practices, guidelines and standards at institutional, national and European level.By coordinating mentoring programmes for women scientists, the strategic objective of the project is to contribute to increase gender equality and to improve the position of women in science in the wider Europe, to contribute to create an involving society and, as a result, to help structuring the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond COVID' in the context of a Horizon Europe call.

assistant: **Objectives**

Beyond-COVID (BY-COVID) aims to provide comprehensive open data on SARS-CoV-2, and other infectious diseases across scientific, medical, public health and policy domains. The project will have a strong emphasis on mobilising raw viral sequences, helping to identify and monitor the spread of SARS-CoV-2 variants. It will further accelerate access to and linking of data and metadata on SARS-CoV-2 and COVID-19, enable federated data analysis conform with data protection regulations, and harmonisation and management of meta-data and sample- identifiers, as well as long-term cataloguing to ensure interoperability of national and global efforts.BY-COVID will align with the One-Health approach building on the latest technological advances,  exploiting and contributing to the European Open Science Cloud capabilities for data access and federation as well as relevant standards and policies for managing, sharing and reusing research data, and work closely with the proposal funded through the sibling-topic from the emergency call (HORIZON-INFRA-2021-EMERGENCY-02). BY-COVID will integrate established national and European infrastructures including ELIXIR, BBMRI, ECRIN, PHIRI and CESSDA. It will build on existing efforts, such as the COVID-19 Data Platform and the Versatile emerging infectious disease observatory project (VEO), thereby maximising efficiency. Synergies with the European Health Data Space will be developed.BY-COVID is a truly interdisciplinary (55 partners from 19 countries) project bringing together stakeholders from the biomedical field, hospitals, public health, social sciences and humanities in an unprecedented and unique effort and will increase European readiness for future pandemics enhance genomic surveillance and rapid-response capabilities. The outputs of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Animal Communicators: Intuitive communication as a key to dialogic multispecies methods'.

assistant: **Objectives**

As the ‘social’ in social sciences is rethought beyond the human, multispecies research across disciplines increasingly asks how to speak with and for non-human others. I pose that intuitive interspecies communication (IIC), a strategy practiced by successful animal communicators to engage in explicit, detailed, two-way communication with non-human animals, holds uncharted resources for doing research with rather than on animals. Research on IIC has been curtailed to specific domains and mythologized, while the worldwide boom in professional animal communicators has been ignored. ANICOM’s unique engagement with animal communicators’ practical strategies for relating across nature/culture and mind/body dichotomies is ground-breaking in the often largely theoretical discussions of the ontological and species turns. It simultaneously unsettles continued divides between humans and animals as well as dominant and subjugated ways of knowing. The project triangulates participant observation, Q method, interviews and audio-visual methods (including video-diaries and video-elicitations) with natural science approaches, to collaboratively work with six expert animal communicators and a variety of animals in Europe and Africa. It addresses unexplored possibilities for cross-fertilization between new materialism and posthumanism on the one hand, and Indigenous studies and knowledge systems on the other, while relying on the latest insights in biosemiotics and animal cognition. It thus develops transdisciplinary innovations that include non-human animals as full research participants, while achieving a deeper reflexivity on the limitations of humans thinking animals outside the human-animal relationship. It’s ultimate objective is to establish the resources and foundation for dialog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination and control of cooperating heterogeneous unmanned systems in uncertain environments', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

GREX is the Latin word for a herd - and such a herd or group is the nucleus of this project. It is the main objective to create a conceptual framework and middleware to coordinate a swarm of diverse, heterogeneous physical objects (exemplary robotic vehicles) working in cooperation to achieve a defined practical goal in an optimised manner. The emphasis will be placed on methods and tools enabling a solution of problems that cannot be solved by one system alone, and which can ensure a better and provable quality of the results. Due to their increasing importance for European industries and research (e.g. biotechnology, pharmacy, or homeland security), the emphasis will be placed on the coordination of marine vehicles, which are becoming the main tool for the exploration and exploitation of the ocean. The technical problems that must be solved are far more complex than those that occur on land or space. The absence of reliable navigation and communication systems and the presence of an unpredictable environment present complex problems that do not occur in other fields. However, the solutions and systems developed in this project can be adopted to other application fields.The project goal is the development of theoretical and practical tools for multiple system cooperation, bridging the gap between concept and practice. The technology developed must be widely generic in order to interface pre-existing heterogeneous systems. Methods that address the problems caused by faulty communications will be developed and tested. A coordinated mission control, enabling end-users to effectively program and follow the state of progress of multi-vehicle missions will be implemented. Programming will use formal methods for software validation. The use of perception and communication tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Natural Enzymes for Ecological Detergents to improve biologically certified Washing products' to be submitted under Horizon 2020.

assistant: **Abstract**

The project NEEDbioWash aims to develop and demonstrate the production of an organic, GMO-free enzyme product by solid state fermentation (SSF) which can boost the washing performance of eco-certified laundry products significantly. It is well-known that enzymes can considerably increase the washing performance as they can degrade stains, which are not removed by surfactants. However, conventional enzymes are not allowed in eco-certified laundry detergents due to the use of GMOs during the production process. The innovative idea of NEEDbioWash consists in using the solid state fermentation technique to avoid the need of genetical modification to enhance productivity.  The market of organic food and non-food merchandise is growing rapidly, both in the European and the global market growth rates of up to 20% are to observe. This is due the raising awareness of the customers to more healthy products, more responsible use of resources, better working conditions, fair traded goods and animal welfare. In organic-labelled products ingredients produced from or by GMO are strictly forbidden, as the influence of GMO on the human health and the environment are not yet satisfyingly investigated. Organic products aim to be produced as natural as possible, including the used raw materials. We are convinced that it is time to provide conscious customers also an environment-friendly laundry detergent product which is entirely natural and has still outstanding washing performance, as people nowadays have – also in the organic community – no time to care about dirty laundry. This is as well the outcome of SME instrument phase 1 project SSFENZYMES (GA: 740224) finished in May 2017 where a huge market potential for NEEDbioWash within Europe as well as world-wide was confirmed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enabling advanced pre-combustion capture techniques and plants' under Seventh Framework.

assistant: **Concept**

DECARBit responds to the urgent need for further research and development in advanced pre-combustion capture techniques to substantially reduce emissions of greenhouse gases from fossil fuel power plants. The project will accelerate the technology development and contribute to the deployment of large scale carbon capture and storage (CCS) plants in line with the adopted European policies for emission reductions.   DECARBit- short for “ Decarbonise it”, is established by 16 legal entities constituting the core group of the project. These encompass 5 leading industrial technology providers, 2 technology end-users (1 utility and 1 oil&gas company) and 9 highly ranked RTD providers representing in totality 8 countries.  The project focus is to pursue the search for improved and new pre-combustion technologies that can meet the cost target of 15€/ton CO2 captured as stated in the Work Programme.  DECARBit is designed as a Collaborative Large-scale Integrating Project. The RTD activities are structured in 5 sub-projects directly responding to the objectives of the Work Programme: • SP1 System integration and optimization • SP2 Advanced pre-combustion CO2 separation • SP3 Advanced oxygen separation technologies • SP4 Enabling technologies for pre-combustion • SP5 Pre-combustion pilots  The project activities comprise theoretical and experimental investigations leading to extended pilot testing. Key expected impacts of DECARBit, all complying with the Work Programme are:  * Cost reduced pre-combustion capture of CO2 promoting the development and deployment of large scale CCS plants (10-12 by 2020). Further industrial uptake is strengthened through an Industrial Contact Group established within the project framework  * Strengthen the competitiveness of the European industry and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Smart Motorcycle helmet with integrated health monitoring system, accident detection and eCall compliance.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

NZi-Vital is the first smart helmet for powered two wheelers integrating a vital sign monitoring and accident detection system capable of automatically contacting emergency services in the event of an accident, and providing accurate and valuable information (position, heart rate), without the need of human interaction. The eCall (emergency call) is performed through an APP previously installed in the user´s smartphone, which also warns the rider in case of bad health conditions. This APP allows real-time monitoring and post-ride analysis by the user. The system incorporates an audio communication module (headphones and microphone) to provide a direct voice channel with the emergency staff. So as to ensure a maximum reliability, it includes a wind power generator that, on average, generates enough energy for the whole system.125c.c. and above motorcycle users comprise the target market of the NZi-VITAL helmet, since they will maximise the benefits of eCall (reduction of fatalities and severe injuries in roads) compared with more urban oriented vehicles.NZi-VITAL will promote the implementation of reliable eCall systems in powered two wheelers. eCall is estimated to achieve 7,5% fewer fatalities and 6% fewer hospitalisation of 1 or more days(1). This project will therefore support some EU initiatives adopted to reduce the number of deaths on Europe’s roads, such as the 2011 White Paper and the European Road Safety Policy Orientations 2011-2020.During this phase1, a comprehensive investor-ready feasibility study of the NZi-Vital will be drawn so as to guarantee the technical and commercial viability of the project and as well as building up the technical plan for phase2.Preliminary market projections shows a Return on Investment of 3.4 for the first five years of commerci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COmmercializing first-in-class dCTPase Inhibitors for treatment of hematological Cancers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In our ERC grant GEnetic NEtworks as a tool for anti-CAncer Drug Development we used siRNA screening and geneticnetworks to identify dCTPase being involved in DNA repair and replication. Further studies revealed that dCTPase plays arole in the degradation of nucleoside analogues used in cancer treatment. We then used an RNAi approach to validatedCTPase as a target to improve nucleoside analogue therapy. The dCTPase protein was purified and we set up anenzymatic high-throughput assay to screen >65,000 compounds, which generated hits that inhibit dCTPase(IC50~1-10μM). Using in house medicinal chemistry we developed TH1217, a low nM potent and selective dCTPaseinhibitor with favourable pharmacokinetic properties. TH1217 synergistically induces apoptosis and cell death incombination with cytidine analogue treatment in cancer cells in vitro and in vivo, but shows no increased toxicity in nontransformeddividing cells. Here, we want to explore the commercial potential of the dCTPase inhibitors identified in theERC grant.In this programme, we will, with the company Oxcia AB, establish the viability of the business programme using technicalanalysis, develop a business strategy and direction, specifically secure IP, perform market analysis, develop a businessplan, manage preclinical development and prepare for clinical trials in collaboration with clinicians and regulatory bodies,IMPD application to Medical Products Agency and identify and discuss with potential commercialization partners andfunding agencies to support cost of clinical trials. We have a non-profit foundation that owns our IP rights in an effort tosecure long term support for translational science aimed at bringing new therapies to patients. In our planned businessmodel, we start a new company that holds an exclus