RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Methods to improve the supply of marine organisms for pharmaceutical-related natural products chemistry' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Prototypes of CAM stations from Dassault, EPFL, Openmind. - Prototypes of CNC with STEP-NC interface from OSAI and SIEMENS AG. - STEP-NC database (SW) for data maintenance from WZL Aachen - Specification of improved data model for ISO integration in ISO DIS 14649, AMT, Siemens AG, WZL, ISW. - Prototype demonstrations for the technologies milling, contouring, EDM from all partners. - Results of usability test for milling from DaimlerChrysler, Franci and Volvo. - Results of usability test for Wire-EDM from Wyss Marine organisms are a rich source of potential and valuable new drugs. Obtaining enough specimens of species of interest without incurring great expense and environmental damage is, however, a major limitation to successfully exploiting this resource. Methods to improve the supply of quality of organisms for drug-related natural products research represent a market for aquaculture companies and as an opportunity for European SME's involved in such research to developed competitive advantages over American and Japanese rivals in the race to discover and market new drugs. The research project will concentrate on two main areas; - the adaptation of existing and the development of new aquaculture techniques for the production of non-food related invertebrates such as sponges, bryozoans and tunicates. - the development of methods to culture bacterial symbionts from marine invertebrates which contain interesting chemicals that may be of bacterial origin. The project will last two years and involve SME's whose main activities involve the exploitation of natural marine resources and drug companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SOLID-STATE LITHIUM METAL BATTERY WITH IN SITU HYBRID ELECTROLYTE' (SEATBELT).

assistant: **Innovation**

As of 2025, new generations of Li batteries based on silicon/carbon (Gen. 4a) and Li metal (Gen. 4b) anode, where flammable liquid electrolyte is replaced by a non-flammable solid-one, will take over the current Li-ion device. However, only all-solid-state Gen. 4b Li batteries are expected to fulfil the needed cell gravimetric energy density specifications demanded by electromobility and stationary applications. Therefore, SEATBELT ambition is to generate a local EU industry that revolves around a cost-effective, robust all-solid-state Li battery comprising sustainable materials by 2026. SEATBELT intends to achieve the first technological milestone of developing a battery cell (TRL5) meeting the needs of Electric Vehicle (EV) and stationary industry. The low-cost SEATBELT cell is safe-by-design with sustainable and recyclable materials, reaching high energy densities (>380 Wh/kg) and long cyclability (>500 cycles) by 2026 in line with the 2030 EU targets. The cells are produced by low-cost solvent-free extrusion process comprising a combination of innovative materials: thin Li metal, hybrid electrolyte, a safe cathode active material without critical materials and thin Al current collector. The cell design being optimized by interface (operando and atomistic modelling) and process (machine learning) methodologies. In addition, new in situ imaging instrumentation will be developed to investigate safety properties and mechanical deformation to assess cell safety in real conditions. An innovative recycling cycle from materials to cell level will be also established. Thus, SEATBELT will be the start point of a first EU all-solid-state battery value chain, whose main players in RTD and Industry sectors are within the consortium. So, cells and modules will cycle using industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessing climate change effects on land use and ecosystems: from regional analysis to the european scale' (ACCELERATES), addressing dissemination and exploitation.

assistant: **Impact**

The proposed project will study the impact of climate change on land use and biological resources in managed ecosystems. The integration of existing impact models of agriculture, forestry, species distribution and habitat fragmentation within a common framework will enable impacts to be synthesised across sectors, disciplines and global change problems. The principal deliverable will be a method for the integrated assessment of ecosystem vulnerability arising from environmental change in Europe. Vulnerability will be assessed using key physical and economic indicators at both the European and regional scales. Critical stress factors (or thresholds) of climate change will be derived from the integrated models. This will assist in the development of strategies for the sustainable management of land use change and nature conservation. The research will provide information supporting the conventions on climate change and biological diversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolving properties of rocks during fracture growth : from numerical to experimental and in-situ experiments', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

AIMS AND OBJECTIVES My research aims are to investigate the physical properties of fractured rock masses at different stages of fracture growth. The objective of the research is therefore to elucidate how the evolution of the structural heterogeneity of rock masses affects seismic wave propagation, electrical conductivity, bulk permeability and solute transport. The scientific work is divided in five work packages which include the modelling of fracture patterns, data analysis from in-situ and laborato ry experiments as well as applications directed towards the management of sites of geophysical exploration (e.g. reservoir exploitation, waste repository). METHODS The scientific methodology is an iterative process based on comparisons between experime ntal results and the predictions of the numerical models. A cellular automaton model with long range interaction will be used to describe an evolving population of fractures. Synthetic fracture patterns will be compared to observations and used as input into pre-existing numerical codes. Laboratory and in-situ experiments conducted under the guidance of Prof. Zamora will provide an unique opportunity to address similar problems over a range of scale from the millimeter to the meter. Practical applicati ons will result from collaborations with institutes and private companies specializing in the management of geological formations. SIGNIFICANCE OF RESULTS It is critical to characterize the structural heterogeneity of rock masses in order to help susta inable development issues in geological environments. In the framework of this project, an independent set of geophysical observations will improve the understanding and the modelling of transport and deformation processes in the brittle crust. This res earch has therefore futu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ProofCert: Broad Spectrum Proof Certificates' (PROOFCERT).

assistant: **Innovation**

There is little hope that the world will know secure software if wecannot make greater strides in the practice of formal methods:hardware and software devices with errors are routinely turned againsttheir users.  The ProofCert proposal aims at building a foundationthat will allow a broad spectrum of formal methods---ranging fromautomatic model checkers to interactive theorem provers---to worktogether to establish formal properties of computer systems.  Thisproject starts with a wonderful gift to us from decades of work bylogicians and proof theorist: their efforts on logic and proof hasgiven us a universally accepted means of communicating proofs betweenpeople and computer systems.  Logic can be used to state desirablesecurity and correctness properties of software and hardware systemsand proofs are uncontroversial evidence that statements are, in fact,true.  The current state-of-the-art of formal methods used inacademics and industry shows, however, that the notion of logic andproof is severely fractured: there is little or no communicationbetween any two such systems.  Thus any efforts on computer systemcorrectness is needlessly repeated many time in the many differentsystems: sometimes this work is even redone when a given prover isupgraded.  In ProofCert, we will build on the bedrock of decades ofresearch into logic and proof theory the notion of proof certificates.Such certificates will allow for a complete reshaping of the way thatformal methods are employed.  Given the infrastructure and toolsenvisioned in this proposal, the world of formal methods will becomeas dynamic and responsive as the world of computer viruses and hackershas become.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'TEchnologies and scenarios For Low Emissions Shipping'.

assistant: **Innovation**

Reduction of emissions in shipping is currently driven by new regulations and impact on wealth and climate change, while traffic steadily grows at up to 6% rates yearly in spite of economic recession. Ships on port approach, maneuvering up to mooring and on loading and unloading, also affect the local population. TEFLES addresses both sea and at port emissions scenarios by developing after treatment technologies and combining a selection of innovative and promising technologies with potential high impact, integrating them and assessing their impact with models on sea and port operation scenarios.In addition to after treatment solutions, novel aplicable technologies reducing emissions in operations and reductions in the time of operations at port are also considered. Shore power connection, power generation, propulsion, and advanced use of residual heat applications are included as high potential impact emission reduction solutions.The assessed technology solutions and models are then integrated on the impact models of the sea and port scenarios, and then validated on a Atlantic MoS  scenario including head ports. The simulation models will also be applicable to other shipping scenarios.Economic aspects, cost benefit, and regulatory and policy issues are further considered. IMO, EMSA, and national and regional administrations will be consulted, and an end users group will be set up to enlarge the partnership, which already includes ports, specialised industries, and a shipyard. A Short Sea Shipping Association and one of the most qualified MoS operators have adhered through letters of interest.Each scenario model will be completed with a final workshop after validation. Dissemination through Beta testing seminars on use of the models will be provided, as well as a web pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structural margin improvements in aged-embrittled RPV with load history effects' (SMILE) under Fifth Framework.

assistant: **Objectives**

The Reactor Pressure Vessel is an essential component liable to limit the lifetime duration of PWR power plants. Its behaviour in service is limited in time due to irradiation-induced embrittlement. The safety analyses performed at the European level do not take into account the effect of load history / warm pre-stress (WPS) of the defects. The SMILE project aims to give sufficient elements to demonstrate, to model and to validate the beneficial WPS effect. The objective is to propose a harmonised way of taking into account this generic phenomenon in the safety studies. It will permit a precise estimation of a potential fracture event, and would also allow plant life extension resulting in a long-term economic benefit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling the cellular responses to aberrantly-folded and aggregated proteins' (PROTEOTOXNET).

assistant: **Innovation**

Protein aggregation diseases are associated with the intracellular accumulation of specific misfolded protein aggregates, that are directly implicated in cellular dysfunction. A range of human disorders of previously unknown nature now falls into this category. The mechanisms of aggregation-induced cell degeneration are however unclear, resulting in poor therapeutic strategies. In this project we will characterize the network of cellular responses to a set of disease-related aggregation-prone proteins (APPs) and determine how to efficiently modulate proteotoxicity. In a discovery phase, we will use proteome-wide screens to identify functional modules that sequentially respond to APP aggregation. A novel method to probe conformational changes of proteins in their biological matrix will be applied to quantify concomitant changes in APP conformation during the toxicity cascade. Our eminently quantitative approach will allow us to characterize the kinetics of intracellular aggregate formation and the resulting cellular responses. A set of biological markers for different functional modules and toxicity stages will be measured using a selected reaction monitoring-fingerprint assay, through a set of genetic and chemical modulators of proteotoxicity. This will unravel how modulators rewire or compensate for the deregulated networks and suggest their most efficient combinations. The multi-level information will be iteratively integrated with prior data and network structure. Emerging hypotheses will be tested using a combination of genetic and biochemical tools and targeted proteomic experiments. This project features novel concepts and methods and will allow us to unravel the molecular events accompanying the onset of proteinopathies and their modulation. It will positively im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Fast Throughput Drosophila Model to Identify Drug Treatments for Age-related Hearing Loss (ARHL)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SHORT SUMMARY ABSTRACT  (2,000 characters max.)The widespread increase in Hearing Loss is one of the major threats to future well-being in ageing human societies. The World Health Organisation (WHO) expects that by 2050 more than 900 million people will suffer from disabling hearing loss (i.e. a hearing loss >40dB in the better hearing ear for adults and >30 dB for children, respectively). The corresponding global cost is estimated to be more than US$ 1 trillion per year. The associated societal costs however - and costs to individual well-being – exceed the monetary domain. Hearing loss threatens to erode the very core of human social cohesion, namely their ability to communicate by speech. Within the various forms of hearing loss, Age-related Hearing Loss (ARHL) carries the vast bulk of the global disease burden. Nearly 1 out of every 3 people over the age of 65 is affected by disabling ARHL. Urgent action – and faster progress – is required. We here offer a novel way how to expedite this effort. Based on preliminary data generated in an ERC-funded project on the interrelation between the auditory and circadian system, we devised an accelerated model of Age-related Hearing Loss (aARHL) in the fruit fly Drosophila melanogaster. In this project we will (i) test, validate and apply the Drosophila aARHL model in order to identify novel compounds that can be used to counter-act ARHL in humans and (ii) add our novel experimental paradigm as a powerful new tool to the drug discovery pipeline dedicated to curing (or preventing) human deafness. Most crucially, we will closely interact with partners from pharma and biotechnological industry and the UCL Innovation & Enterprise teams, to tap the project’s full biomedical and commercial potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Qlice: Environmentally-friendly system to combat sea lice in salmon farms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The problem: Feeding an expected global population over 9 billion by 2050 is a daunting challenge. Aquaculture can play a major role in acting on this challenge while also meeting the so needed sustainable growth in food production. Salmon farms have become very large nurseries for sea lice – the main pathogen affecting salmon in net-pens (sea cages) – materializing in a huge threat both to the salmon farming industry and to wild salmon populations. Money spent by the Norwegian salmon farming sector on combating sea lice surpassed €500 million in 2015. Uncontrolled sea lice infestations are also affecting wildlife because wild juvenile salmon have to pass through the fish farms before they reach their offshore habitat.The solution: The Qlice method is a novel and environmentally-friendly solution, consisting of a chemical agent (particulate calcium oxide) and a delivery system – aiming at combating sea lice infestations in salmon farming. Unlike other treatments, Qlice will exert a positive impact on the environment by buffering the seawater acidification caused by intensive farming activity, i.e. excess feeding and wastes. Our results have shown up to 81% reduction in in sea lice and no fish mortality this reduction is enough to keep sea lice levels well below the permitted limit (less than 0.5 female adult sea lice per salmon on the net-pens) by Norwegian authorities.The market: Aquaculture production already exceeds 97 million metric tons (live weight), while the value of international aquaculture trade amounts to USD157 billion. The production of farmed salmon has grown more than 600% since the 1990’ and it is currently growing at 6% compound annual growth rate. Total market size for Qlice in Norway (approx. 50% of the global market) is around or €150 million – the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Developing Multipurpose Nicotiana Crops for Molecular Farming using New Plant Breeding Techniques'.

assistant: **Concept**

A group of New Plant Breeding Techniques (NPBT) has opened unprecedented opportunities in agriculture. Those NPBTs are at least as efficient and often more precise than previous traditional and GM techniques, while circumventing the introduction of heritable transgenes from distant species in the plant genome. Properly communicated, NPBTs are expected to gain wide acceptance, especially when applied to breeding objectives which are seen as beneficial for the society. A well-perceived objective is Molecular Farming, which refers to the use of plants for the production of valuable biomolecules (e. g. biopharmaceuticals). Cultivated tobacco (Nicotiana tabacum) and its close Australian relative Nicotiana benthamiana, are preferred species in Molecular Farming due to their favourable features: non-food crops, easy tissue regeneration, high productivity, rich secondary metabolism and availability of genetic tools. In sharp contrast, traditional tobacco cultivation is in serious decline in the EU, causing serious social problems in many rural areas. NEWCOTIANA aims to revitalize those areas by breeding efficient Nicotiana biofactories of high-value non-smoking products as alternatives for traditional tobacco crops. NEWCOTIANA will develop the most advanced tobacco NPBTs toolbox, easily transferable to other plants. This will position EU in the avant-garde of breeding innovation. This toolbox will be used to create elite multipurpose Nicotiana varieties improved in product-specific traits (bioproduct quality, stability and yield), next to more general traits as biomass, resilience and biosafety. The “Newcotiana” varieties will be carefully tested in relevant pre-industrial environments for the production of end-value chemicals, namely proteins and metabolites for health and nut