RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Broadbandloop' (BBL).

assistant: **Concept**

The objective of the BROADBANDLOOP project is to define and test in field trials a concept for a cost-effective broadband access network, which will allow fibre to migrate gracefully into the local loop as bandwidth demand increases. The project will demonstrate a graceful upgrade of PONs to high bandwidth and use high speed VDSL modems to upgrade coax and copper twisted pair networks, to transport broadband services over the last drop into the customers' premises. The target customer group is small to medium size business enterprises and residential customers.Demonstrate low cost, simple PONs which are integrated into an SDH network structure;Demonstrate that PONs can be upgraded cost-effectively to provide broadband services;Demonstrate capability of existing copper networks to provide broadband services;Demonstrate that PONs can be made compact and flexible;Demonstrate a low cost introduction solution for broadband services.Achievements so farProduced requirement specification for the broadband access networkImplemented traffic simulator and estimated bandwidth demand related to service quality for different broadband service scenarios.Gave recommendation to network design.Specified and partially implemented infrastructure for field trials in Portugal, Denmark and PolandPerformed measurements and analysis of performance of copper network to evaluate capability to transmit broadband signalsPerformed life cycle cost study for different xDSL and fibre implementation scenarios for residential customers. Recommended potential areas for cost savings which will be taken into account in the field trials.prototype wavelength-switchable optical network unitExpected ImpactObtain acceptance of PONs as a cost-effective dependable tool for provision of broadband services for resid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting epilepsy with phototherapeutics' (PhotoTherEpi).

assistant: **Concept**

As photo-activatable drugs (PDs) can be precisely controlled in space and time, caged and switchable photoactivatable drugs (CPDs, SPDs) are rapidly emerging as potential therapeutics for varied forms of cancer, vision loss, diabetes, or pain disorders. Despite their potential, PDs have not been exploited for epilepsy, a common, often debilitating neurological disorder. As 30% of epilepsies are medically intractable, and antiepileptic drugs often cause multi-organ side effects, PDs could break new therapeutic ground. PDs can be applied on demand, and locally activated/inactivated in single or multiple epileptic brain areas in a targeted fashion. This minimizes systemic side effects, and allows the application of potent drugs from other fields yet unthinkable in routine epileptology (e.g. general anesthetics). Importantly, being small molecules, different PDs can be combined or easily exchanged, and do not require protein expression. Using current and new PDs, we aim to control epileptic networks in vivo in a realistic epilepsy mouse model, and resected human brain tissue from patients with intractable epilepsy. Aim 1 will quantify antiepileptic potency of a range of PDs in human tissue using field potential and patch-clamp recordings, and cellular scale 2-photon imaging. In aim 2, PDs will be evaluated in vivo using wireless video-EEG, imaging and light-fiber-targeted drug photoactivation in chronically epileptic mice. Further, by use of caged immunomodulators, we will explore disease-modifying capacity of targeted PD photoactivation in epileptogenesis and chronic epilepsy. PhotoTherEpi will establish targeted photopharmacology as a versatile, and powerful new approach to control focal epilepsy, which could jumpstart a new branch of translational epilepsy research. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'South Eastern European GRid-enabled eInfrastructure Development'.

assistant: **Innovation**

SEE-GRID aims to provide specific support actions to assist the participation of the SE European states to the pan-European and worldwide Grid initiatives by establishing a seamless and interoperable pilot-Grid infrastructure that will expand and support the European Research Area (ERA) in the region. THe SEE-GRID vision is to pave the way towards the provision to distributed research communities in the region with the independent of geographic location, round-the-clock, common market of computing resources. The interconnection of the regional infrastructure to the pan-European and worldwide Grid initiatives will translate into benefits for the smaller, less-well resourced sites in SE Europe to access computing power that would otherwise be unaffordable. In this perspective, the proposed initiative will ease the digital divide and release the scientific & productive talents of the region and will allow equal participation of the targeted countries in pan-European Grid Efforts in the immediate future. The aim and vision will be accomplished through the following objectives: - Create a human network in the area of Grids, eScience and eInfrastructures in SE Europe. - Integrate incubating and existing National Grid infrastructures in all SEE-GRID states. - Capture eScience user requirements for Grid middleware and services in the region. - Support feasibility studies and provide roadmaps and cookbooks for the rapid integration of the SEE Grid area to the ERA. - Build upon and exploit the infrastructure provided by the Gigabit Pan-European Research and Education Network (GEANT) and the South-East European Research and Education Networking (SEEREN) initiative in the region. - Migrate and test Grid middleware components and APIs developed by pan-European (e.g. EGEE, etc) and n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Patients-centered SurvivorShIp care plan after Cancer treatments based on Big Data and Artificial Intelligence technologies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

PERSIST aims at developing an open and interoperable ecosystem to improve the care of cancer survivors. The key results to be achieved by partners are: increased self-efficacy and satisfaction with care as well as reduced psychological stress for a better management of the consequences of the cancer treatment and the disease, resulting in an improvement in health and wellbeing and a faster integration into the labour market, where applicable, compared to usual care (KR1); increased effectiveness in cancer treatment and follow-up by providing prediction models from Big Data that will support decision-making and contribute to optimal treatment decisions with positive consequences in the QoL and the health status of survivors (KR2); and improved information and evidence to advance the efficacy of management, intervention and prevention policies/strategies in order to timely treat side effects and, if possible, avoid secondary diseases and fatal events. The long-term result will be to reduce the socio-economic burden related to cancer survivors’ care (KR3). The ecosystem proposed consists of a Big Data platform to be built on top of an open infrastructure from one of the partners and a mHealth application for patients. The main building blocks to be developed are a multimodal sensing network running on a smart phone that will collect relevant data regarding the wellbeing of the patient; predictive models from anonymised health data from thousands of breast and colorectal patients; and modules essential for the development of a decision support system, which will employ the predictive models mentioned. Furthermore, PERSIST will contribute to establish evidence on the use of liquid biopsy techniques to the follow-up of cancer patients treated with curative purposes. A pilot s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Systematic search for new physics in the b-b system and in b meson decays' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content  B-physics has become one of the most promising sectors of particle physics to observe New Physics effects. More specifically, two types of Flavour Changing Neutral Current processes could be particularly sensitive to these effects: CP violating asymmetries induced by the mixing in the B system and rare B decays. There are two main motivations for the interest in these processes: an experimental one, the expected increase in statistics in the planned B-physics facilities, and another theoretical, the possibility of extracting the angles of the Unitarity Triangle from CP asymmetries in a clean way and also the recent progress in the computation of the next-to-leading QCD corrections to rare B decays. The aim of the present research project is twofold. On the one hand, to undertake a systematic analysis of all possible ways that New Physics could manifest in measurements of the angles of the Unitarity Triangle: by generating new phases, showing departures from the Standard Model predictions and through inconsistencies in the measurements. And at the same time, to look for possible sources of these discrepancies in alternative models to the SM. On the other, to construct a general effective lagrangian for rare B decays to extract the data in a model independent way and afterwards to classify a large set of models according to the predictions they give for the coefficients of the effective lagrangian. Training content (objective benefit and expected impact)  The expected impact and benefit of the present proposal are to provide with a systematic analysis to determine where New Physics may be found in the B system and rare B decays and to identify and discriminate between the models that could be involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Modelling Complex Networks Through Graph Editing Problems'.

assistant: **Objectives**

The goal of the PROXNET project, which will be realised during the mobility of Christophe Crespelle in the Algorithms groupof Bergen, is to open a new way for analysing, modelling and managing complex networks, through graph editing problems.The reason why these networks are said to be complex is that they are loosely structured, due to the part of uncertainty andrandomness they contain. On the other hand, the real-world context where they come from strongly constrains theirorganisation and gives them some specific structure. The difficulty in retrieving this structure is that it is altered by the noiseresulting from the uncertainty and randomness that these networks contain. In the PROXNET project, we will retrieve thehidden structures of complex networks thanks to graph editing problems, which consist in changing some adjacencies of thegraph in order to obtain a desired property. We will develop the algorithms necessary to solve graph editing problemsrelevant to our approach on huge instances of graphs, we will apply them to real-world datasets and use the results obtainedin order to design new models of complex networks.One key theoretic challenge in this context is to optimally solve the editing problems considered, which are computationallydifficult (NP-hard). A very promising technique to do so is preprocessing. It consists in reducing the size of the instance byapplying some reduction rules, in such a way that the optimal solution on the reduced instance is the same as the one on theoriginal instance. The Algorithms group of the University of bergen is a world-wide leader on this topic which will constitutethe main training action of Christophe Crespelle during his mobility.


**Keywords:** graph algorithms, complex networks, graph modification problems, preproce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Second international symposium on food packaging: ensuring the safety and quality of foods'.

assistant: **Objectives**

The balance is fine between encouraging packaging development and innovation, responding to environmental considerations that benefit consumers , and regulatory control ensuring their protection. Understanding chemical-chemical processes in food packaging systems is crucial both as a way to drive forward innovation. and as a means to ensure regulatory controls based on sound science. Following success of the first symposium on the subject (Budapest, September 1996), a follow-up related subjects : food packaging innovations; physical transport processes in packaging; sensory impact of packaging materials; safety/quality aspects of recycling/re-use; new analytical approaches/test procedures; plastics, paper, board, other materials; risk assessment of packaging materials; environmental impact and development of environment-friendly materials; irradiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Synthesis of Cyclic Peptides using Efficient Carbon-Carbon Bond-Forming Reactions'.

assistant: **Concept**

The search for new drugs and antibiotics remains a very important activity. In this context, peptides continue to play a central role. There are many examples of biologically active peptides, including examples of cyclic and cyclic structures. Unlike their cyclic congeners, cyclic peptides exhibit substantial resistance to proteoloyticenzymes, and can exhibit both irreversible and reversible inhibition of such enzymes, and for this reason they are potential drugs. Some examples of natural products falling into this class include the angiotensin converting enzyme inhibitor K-13 and the amino peptidase inhibitor OF4949-III. There is therefore substantial interest in the preparation of analogues of these compounds as potential therapeutic agents. The Host group has recently completed the shortest synthesis of K-13 so far reported. This new route relies on the preparation of a highly functionalised tripe tide organizing reagent, which can be prepared efficiently from simple starting materials, and which can then be converted using palladium catalysis into the cyclic peptide. With this precedent, the objective of this project is to develop synthetic routes to the naturally occurring antibiotic biphenomycin B and the recently discovered protease inhibitors of the TMC-95 class, which are also macro cyclic peptides, together with less oxidised analogues of TMC-95. It is planned to use a similar strategy, involving the intermolecular coupling of highly functionalised organizing reagents with aryl iodides, catalysed by palladium (0). The benefit of this route is that it minimises the use of protection and deprotectionsteps, thus ensuring an efficient synthesis. The use of peptide derivatives containing two carbon-zinc bonds will also be explored, since this would allow Avery fast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European platform for research on prevention and treatment of coealic disease: a multidisciplinary approach to integrate basic scientific knowledge in clinical applications and food industry' (CDEUSSA) targeting Sixth Framework.

assistant: **Abstract**

Coeliac disease (CD) is a frequent chronic disorder caused by hypersensitivity to food proteins (gluten). CD affects as much as 1% of the Europeans. The health burden of CD is siderably and the negative eomical sequences for society are extensive. The last years an impressive amount of research work on CD has been produced by different European groups and many immunological, genetic and epidemiological factors implicated in CD have been clarified. However, there is a fundamental gap between the groups of researchers working on the basic scientific aspects of CD (immunology, genetics, cereal chemistry) and those working on the clinical and social aspects of the disease (preventive and curative medicine, food industry). The aim of this SSA is to close the gap between basic science on CD and applications of its results in prevention, clinical treatment and food industry. By European collaboration among leaders from disciplines beyond those traditionally used, among others from academia, patient organisations and industry, we will form a platform to generate the scientific basis for innovative research on primary prevention and effective treatment of CD, taking full advantage of genomics/proteomics techniques. To achieve our aims we propose: 1) to organise two European workshops with leading scientific experts, representatives from the industry, coeliac patients organizations and health experts from the European Community, in order to 2) create an operational European Multi-stakeholder Platform of experts on CD from crosscutting research areas, to promote future integrated European research in CD and 3) to offer recommendations to the FP6 and FP7 program on a common European research strategy on novel methods for prevention and treatment of CD by integrating basic science w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A first-in-class therapy for intestinal malabsorption in premature newborns'.

assistant: **Objectives**

Around 10% babies are born preterm, and premature birth is the 1st cause of new-born deaths. Preterm infants are born with an underdeveloped gastrointestinal (GI) tract, causing intestinal malabsorption. At the first weeks of life, adequate nutrition is critical for brain and vital organ development, so infants are placed on central line nutrition until their GI is capable of absorbing sufficient nutrition. However, central line nutrition is inadequate for critical growth and poses life-threatening risks. Thus, a fast transition to oral independence is the goal for improving outcomes. ELGN-GI is the first drug for stimulating gut maturation for rapid transition to oral nutrition. It is safe and demonstrated to reduce 4 days dependent on Parenteral Nutrition, ~7 days in high-level NICU, ~7 days in hospitalization period, and to contribute to 40% reduction of life-threatening infections and Necrotizing Enterocolitis.


**Keywords:** Neonatology,Preterm infants ,drug,paediatric,Gastrointestinal,patient-tailored therapy,hospitalization,healthcare system,nanotechnology,insulin,orphan disease,NICU,intestinal malabsorption,nutrition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanistic Microscale Approach to the Microbial Degradation of Oil-Droplets in Subsea Crude Oil Releases' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

In oligotrophic marine ecosystems, the natural or accidental release of crude oil marks the beginning of a season of feast for indigenous microbial consortia that have developed appropriate adaptive machinery to access and assimilate hydrocarbons. Biodegradation and bioemulsification are among the key processes by which marine microbes strongly affect the transport and fate of crude oil in the sea. Unraveling of the coupled physical and biochemical interactions between microbes and oil droplets will be a major enabler for achieving a new level of prediction of crude oil dispersion as well as for developing more efficient bioremediation techniques to combat oil spills in marine environments. The proposed research project aims at an improved understanding of the fundamental microscale mechanisms that underpin oil biodegradation with a highly innovative focus at both the single-droplet and droplet-population levels. In particular, at the single-droplet level, our focus is on the droplet-microbe interactions and the dynamics of biofilm formation over the oily substrate. Ultimately, the developing interfaces between biofilms, oil and water will be tracked and quantitatively visualized. At the droplet-population level, our focus is on the evolution of the droplet size distribution (DSD) and its impact on the average biodegradation rates for a cloud of oil microdroplets (10-60 um). The research methodology is based on a creative combination of state-of-the-art microfluidics, biochemical analyses and computational modeling. All in all, this project is expected to provide a unique and original approach to a fundamental problem in microbial ecology that has wide societal and economical repercussions. Importantly, a profound impetus will be given to the Researcher’s career via str