RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Neuronal dynamics of learning and memory in the mammillary body'.

assistant: **Concept**

At the heart of our individual personalities lie our memories – be it our first time riding a bike, the school graduation ceremony, or yesterday’s football match. Yet, it is estimated that in the coming decades up to 150 million people worldwide will suffer from dementia. To tackle this surge and identify therapeutic interventions, a thorough understanding of the neuronal mechanisms underlying long-term memory storage is necessary. Research in humans and rodents has identified the hippocampus as the brain’s preeminent structure for memory processing. Yet, for memories to become permanently stored and correctly retrieved, the hippocampus needs to communicate with the rest of the brain. One of the main projection targets of the hippocampus is the mammillary body (MB). Over a century of clinical research and lesion studies in rats have established the importance of the MB to form and retrieve long-lasting memories but its peculiar anatomical location has prevented research to uncover the mechanisms underlying this role.In this research programme, we will reveal the role of the MB in memory processing at a cellular, circuit, network, and behavioural level in mice. First, we will make use of recently established genetic tools to ascribe precise causal roles for memory processing to individual mouse MB subnuclei. Next, we will leverage my extensive experience with in vivo two-photon microscopy to image calcium activity from identified MB neurons across multiple days of learning. We will then combine these tools to elucidate the role of reciprocal brainstem inhibition. Lastly, we will use high-density silicon probe recordings to simultaneously record activity across cortical, thalamic and hippocampal sites connected to the MB, as animals are actively engaged in memory tasks.Ov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Soundscape Indices' (SSID).

assistant: **Innovation**

Eighty million EU citizens are suffering from excessive environmental noise and billions of euros are being spent on noise control, under the EU Directive on Environmental Noise. Unfortunately, the conventional approach, i.e. reduction of ‘sound level’, simply does not deliver the required improvements in quality of life. The growing field of ‘soundscape studies’ is addressing this gap by considering sound environment as perceived, in context, with an interdisciplinary approach. However, soundscapes are hugely complex and measuring them as a basis for environmental design requires a step change to the discipline. This research aims to achieve a ground-breaking development through the establishment of ‘soundscape indices’ (SSID), adequately reflecting levels of human comfort, the impact of which will be reminiscent of that of the Decibel scale created by Bell Systems a century ago. This will provide the underpinning science for soundscape in the field of built environment, with wider intellectual goals of moving from noise control to soundscape creation. Key objectives, as coherent steps for achieving the main aim, are: (1) To characterise soundscapes, by capturing soundscapes and establishing a comprehensive database, which will be a cornerstone for the proposed analysis, and an invaluable resource for scientists for years to come. (2) To determine key factors and their influence on soundscape quality based on the database, by conducting laboratory psychological evaluation, physical/psychoacoustic factors analysis, and more importantly, to research at a physiological/biological level, including the use of functional magnetic resonance imaging. (3) To develop, test and validate the soundscape indices, through analysing the influences by various factors, using a number of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced Cell-based Therapies for the treatment of Primary ImmunoDeficiency' to be submitted under Seventh Framework.

assistant: **Abstract**

Primary immune deficiencies (PID) are inherited disorders of the adaptive and innate immune system marked by severe infections, autoimmunity and high risk of cancer. Treatment entails hematopoietic stem cell (HSC) transplantation from allogeneic donors, however in the absence of an HLA compatible donor, HSCT outcome is limited by delayed or suboptimal reconstitution and complications. SCID-X1 and ADA-SCID have been successfully treated with autologous gene corrected HSC, however, associated with safety issues inherent to first generation retroviral vectors. This project utilizes genetically modified HSC and their descendants as immunotherapeutic cells to build a healthy immune system in PID patients, and is carried out by clinical centres, scientists and industrial partners pioneering in the field of advanced therapies and aiming at broad clinical application of safe cell-based therapeutic products. Multicentre phase I/II clinical trials for SCID-X1 and WAS are ready to start. Disease targeted technology to cure ADA-SCID, V(D)J recombination defects and CGD by gene corrected HSC and novel approaches in IPEX and HLH to gene modify already committed cells will be investigated. Based on rigorous preclinical efficacy and toxicology evaluation, flanked by basic studies aimed at improving HSC homing capacity and thymic epithelium regeneration, new clinical trials will be implemented. The consortium will establish a technology platform to implement, harmonize and run controlled, standardized multicentre preclinical studies using state-of-the-art advanced therapy. Strict observance of good practice quality guidelines and regulation of medicinal product development will be ensured. The successful completion of the project will be instrumental to accomplish and broaden clinical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Potassium-Ion electrochemical energy storage in metal-organic hybrid frameworks doped with redox and electron transport boosters' to be submitted under Horizon Europe.

assistant: **Abstract**

Potassium ion batteries (KIBs) offer unique opportunities for low-cost, sustainable, and high-performance electrochemical energy storage required for the electrification of transportation, and for storing energy from renewable but intermittent resources. However, concerted efforts are required to tackle the challenges of KIBs, such as the short life, low energy content, and long charging time. POSIDON will leverage the versatile material toolbox of metal-organic frameworks (MOFs) and graphene derivatives (core expertise of the applicant and host institution, respectively) to design and develop efficient electrode materials, and introduce a paradigm shift in KIBs performance. POSIDON will build advanced hybrid K-ion batteries (HyKIBs) by engineering and studying 1) strategically designed cathodes based on coaxial metallic/MOF nanowires doped with redox-active molecules to boost the conductivity and capacity, and 2) sophisticated two-dimensional anodes based on graphene derivatives with dense out-of-plane and in-plane functionalities as hosts for single metal atoms, acting as nucleation centers for the improvement of reversible deposition and stripping of potassium, of potassiophilicity and impeding dendrite formation, which is catastrophic for the life-cycle and safety. These electrodes will dramatically improve the capacity, the energy content of the HyKIBs, and prolong their life. Moreover, the high porosity of MOFs and the conductivity of the envisioned electrode architectures will promote potassium diffusivity for fast-charging operation. POSIDON will deliver practical cells of HyKIB devices with high performance to pave the way towards the commercialization of potassium-based energy storage, which is vital for a low carbon, sustainable, and fossil-fuel-independent c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancement and control of laser-assisted material processing' (ECOLAMP).

assistant: **Concept**

The NCLA research group has developed considerable expertise in the application of laser technology in advanced manufacturing sectors. These activities have been largely supported by collaborations at a regional level with industry (including SMEs) across electronics, medical device, and aerospace sectors. While some understanding of the laser-material interaction has been developed for specific materials and laser systems, a programme of knowledge transfer in materials science, specifically targeting therm o-physical and thermodynamic simulations, is required to underpin the future activities of the NCLA. To progress the fundamental understanding in the science of laser-assisted fabrication, a transfer of knowledge is proposed on process modelling and imp roved understanding of the novel use of assist gases that can improve laser ablation through chemical or physical interaction, and on the accelerated development of skills in the use of new laser sources (i.e. femto-second, UV diode-pumped solid-state lase rs operating at 266nm, 355nm). The group is already engaged with industry partners on laser processing projects, leading to significant process improvements. While centre personnel have proposed a number of models, researchers have been unsuccessful in obt aining detailed insight into the fundamental thermo-physical processes involved in the laser-assisted processing step. Accurate models, if verifiable experimentally, will be valuable in optimising processes and identifying new applications of the technolo gy. The host has recently acquired new sources and, to maximise their impact, requires expertise and guidance from experienced researchers, from laboratories already proficient in the use of short-pulse (especially femto-second) laser systems. The project will de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Variability in the mutation rate of RNA viruses'.

assistant: **Concept**

RNA viruses are the fastest evolving entities in nature. Such rapid evolution is explained by their mutation rates, which are orders of magnitude higher than those of DNA organisms. The error-prone replication of RNA viruses also has public-health implications related to pathogenesis, antiviral research, or viral emergence. However, current mutation rate estimates vary by more than 100-fold across different RNA viruses and sometimes over one order of magnitude for the same virus, and the causes of this variation remain poorly understood. Here, we plan to investigate variability in the mutation rate of RNA viruses at different levels. First, polymorphic sites in viral polymerases could produce populations with heterogeneous mutation rates, and the spread of genotypes with altered mutation rates might influence viral fitness and disease progression. Second, spontaneous mutations might occur preferentially at some regions of the viral genome, and these mutational hotspots could match genome regions where the selective pressure imposed by the host is strongest, thereby increasing viral adaptability. Third, RNA viruses with different types of genomes, such as single-stranded versus double-stranded RNA or sense versus anti-sense genome polarity might differ in their susceptibility to nucleic-acid damage or host-mediated editing and thus, in their mutation rate. Fourth, RNA viruses with larger genomes might have evolved increased replication fidelity to compensate for their greater genetic load. To address these issues, we will use several biomedically relevant and/or model viruses, including HIV-1, hepatitis C virus, a rotavirus, a coronavirus and a bacteriophage. The experimental procedures will include in vitro replication fidelity assays, ex vivo infections using cell cult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on '23rd Meeting of the European Study Group for Cell Proliferation (ESGCP)'.

assistant: **Innovation**

The ESGCP meetings aim to allow European Scientists and clinicians to present and discuss data in the field of cell proliferation. Understanding the control of cell proliferation (and how this control is frequently lost) is necessary for the early diagnosis and improved (novel) treatments for various diseases, including cancers. Similarly, regulation of cell loss via apoptosis is also crucial. This meeting will address these issues at the molecular level (e.g. signal transduction) as well as in the whole body (dietary manipulation) and combinations of the two (such as in gene therapy, or the studying the effects of ageing on the fidelity of cell replication). Many aspects of the Cell Factory" key action are therefore addressed along with certain aspects of "Food, Nutrition and Health" and "The Ageing Population".Each session of the meeting will therefore have recognised expert keynote speakers and will be accompanied by shorter presentations by delegates - particularly younger (student/postdoctoral) delegates. There will also be a number of poster presentations.These ESGCP meetings have occurred every 18 months (this will be the 23rd meeting) but were originally set up to facilitate scientific exchange between eastern and western Europe. This is no longer the problem it once was and the meetings are therefore now aiming to restructure and evolve into a training forum for younger European scientists - allowing them to gain experience organising meetings and give oral presentations about their work in the presence of international experts. The longer term aim is therefore for young scientists to foster collaborations/gain expert guidance from the more experienced scientists and clinicians, which will then eventually enhance their status in this field (and hence European c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated manufacturing of REciclable hybrid metalthermoplastic COmposites for the TRANSport sector.' (RECOTRANS) targeting Horizon 2020.

assistant: **Abstract**

RECOTRANS project will create new manufacturing system for obtaining multi-material metal composites products suitable for the transport industry; automotive, truck and railway sector. The aim of this project is to integrate unconventional manufacturing technologies such as (microwave) MW radiation and laser joining in current RTM and pultrusion production lines. This integration will contribute to obtain high quality lightweight multi-materials at high production rates; reducing production cost, energy consumption and time to market contributing to reduce CO2 emissions coming from vehicles; truck, automotive and railway
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Action-based routes for numbers: unveiling the core networks of reaching, grasping and number processing in brain damaged and healthy individuals.' under Horizon 2020.

assistant: **Concept**

Grasping and Reaching In Number Processing (GRINP) is focused on the study of the neural underpinnings of number processing and its impairment. Number-related deficits can dramatically affect everyday life. Nonetheless, this impairment is often marginally considered in clinical practice, possibly because the complex nature of numerical disorders makes their diagnosis and rehabilitation quite hard. GRINP builds upon action-based theories of cognition - considering many aspects of human cognition as built on motor action - and on the idea that the neural bases for abstract concepts representation are networks of functionally-related recycled mechanisms. Through a comprehensive approach which couples clinical (neuropsychological) with neuroimaging methods (magnetoencephalography), GRINP tests whether number magnitude recruits the same sensorimotor network involved in planning and executing hand movements. GRINP is timely because it relates the cognitive aspects of number and action with the study of their neural dynamics; GRINP is innovative because it promotes at different levels (scientific, clinical, societal) an action-based approach for the understanding of cognitive impairment. GRINP is based on the convergence between the solid expertise of the Fellow in numerical cognition and behavioural research methods, and the long lasting tradition of the Host in neuropsychological and neuroimaging training and research. GRINP will allow the Fellow to restart research in her native country after more than five years of international research/teaching experience and a maternity break. Thanks to the planned training on advanced neuropsychological (voxel-based lesion symptom mapping, brain tractography) and neuroimaging methods (functional connectivity) the Fellow will broaden he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Paradigm Change in Skin Health: Novel Microbiome-based Cosmetics for Acne and Other Skin Conditions' (SkinMicrobiome).

assistant: **Concept**

S-Biomedic has developed a disruptive technology to directly modulate the skin microbiome, enabling a wide range of applications in dermatology. The first product is a cosmetic for acne prone skin (TRL6) with proven efficacy and safety in an area where competing products are either ineffective or cause severe side-effects. Acne is amongst the 10 most prevalent diseases globally and the main reason for people to consult a dermatologist. It affects the life quality of millions of Europeans and represents a market of €4.4 billion. S-Biomedic’s novel skin probiotic product will be launched in 2021 in selected European countries, and will allow reducing current treatments from years to weeks and preventing the actual relapse episodes of acne.S-Biomedic is leading the skin microbiome field based on a unique combination of approach, technology and careful IPR protection. Backed by global industrial partners with an unparalleled reputation in the personal care industries, such as Johnson & Johnson, DSM and Beiersdorf, S-Biomedic has successfully accelerated its R&D and turned its platform technology into a high-potential product pipeline. However, the ambitious challenge posed by the launch of a new cosmetic product in the market can only be met to its full potential with the support of the EIC pilot. The SkinMicrobiome project will support S-Biomedic in the route to market and accelerate its growth, enabling sales >€55M by 2028, positioning it among the Top 10 acne brands globally, with a projected market share of 2,58%. SkinMicrobiome will allow to hire employees with commercial and marketing background, who will complement a multidisciplinary team led by excellent business and scientific professionals. SkinMicrobiome will become a key cornerstone for the successful launch of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Self-sustaining plant for urban waste recycling' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The intended research project aims at developing a self-sustaining plant for urban waste recycling, powered by a small size pilot unit for energy production (about 2.5 MW) running on industrial solid fuel (RDF) obtained from the recycling of urban solid waste. As it will be the recycling plant itself to produce as by-product the RDF fuel, this will make it possible to: create a self-sustaining system, reducing even more the cost both of the RDF fuel and of the whole recycling treatment (presently energy cost is about 35 % of treatment costs). realise an energy generation prototype, whose outcome is exploitable in any possible industrial site where this kind of power is required. Production of ever better quality RDF from urban solid waste is possible by means of existing separation and recycling processes, through limited modifications to standard operation; this makes RDF solid fuel potentially available at lower cost, which could be reduced even more if the recycling plants themselves were powered by part of the fuel they produce. Two new factors like the availability of recycled RDF and of small size RDF based energy production units (not existing at the moment) make the system economically convenient and may lead to the use of these units in the wide range of small size applications now powered bv fossil fuels (environmental benefit). A research action is needed in order to further optimise recycled RDF and its combustion on small size units, enhancing chemical/phvsical characteristics of recycled RDF and solving related down-scaling effects.