RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hemoglobin based Protein Nanocarriers for Tumour Oxygenation and a more effective Photodynamic Therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A major drawback of Photodynamic Therapy (PDT) and other therapies for cancer treatment is the limited oxygen content, hypoxia, in tumour tissue. In PDT a photosensitizing molecule is delivered to malignant tissue to generate radical oxygen species (ROS). The presence of oxygen is fundamental for ROS generation, ultimately causing the death of tumour cells.This project aims to develop hemoglobin drug delivery nanocarriers in the nano and submicron range for simultaneous oxygen and photosensitizer delivery to tumour tissue for a more efficient Photodynamic Therapy.Hemoglobin-based nanocarriers (HOBCs) will be prepared by co-precipitation of hemoglobin with carbonates and surface coating with bovine serum albumin. The carriers will transport oxygen complexed to hemoglobin while photosensitizer molecules will be entrapped in the core. Carriers will be modified with homing peptides to target them to cancer cells. In vitro studies will be conducted to study the uptake of HOBCs by cells, their intracellular fate, toxicity, and oxygen and photosensitizer delivery. In vivo fate of carriers will be studied in mice with radiolabeled carriers by Positron Emission Tomography and Single Emission Computer Tomography. The efficiency of the HOBCs for oxygen delivery and for PDT will be tested in vitro and in vivo in breast and skin cancer models.A multidisciplinary team has been gathered with scientists at the forefront of Material Science, Self assembly, Physics, Chemistry, Imaging, Molecular Biology and Cancer Therapy from Germany, Estonia, Spain, Brazil, Argentina and Thailand. The participation of a SME will be fundamental for the future commercialization of project developments. OXIGENATED will actively work towards exchanging skills and knowledge through secondments of Early Stag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'In-mill treatment and reuse of process water in paper mills for effluent-free papermaking (CLOSEDCYCLE)'.

assistant: **Innovation**

The objective of the project is to develop cost-effective technology for treatment of paper mill process water at the source in the mill, with such efficiency that treated water can be reused in the mill, replacing fresh water. The expected result is new technology, making possible effluent-free paper production. The technology is to be based on biological treatment optimised for the conditions set by paper production. Bio treatment is followed by biomass separation, using different technologies depending on how low biomass concentration in the reused water is required for the paper quality produced. If removal of colour or smell is needed, polishing with ozone will be done. An automatic control system for dosing of nutrients to the bioprocess will be developed. Optimisation of process configuration and design will be based on tests of paper quality and studies of the microbiology in the process water system when reusing treated water.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mobility for Regional Excellence 2020' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MoRE2020 is a continuation and further development of the FP7-Marie Curie-COFUND programme called “Mobility for Regional Excellence” (MoRE), which Region Västra Götaland was granted in December 2013 (grant agreement no 608743). The half-term external evaluation  of the MoRE programme indicated very positive results. MoRE2020 will offer experienced researchers new and exciting mobility experiences in internationally renowned research and innovation milieus with excellent working conditions and strong triple helix components. It aims to contribute to increasing the attractiveness of research and innovation careers in Europe, to foster excellence across the Union through smart specialisation, and to increase international cooperation.MoRE2020 is a moderately scaled programme – a total of 20 incoming/outgoing fellows will be supported throughout the programme period. Being a small programme, it will compete on quality rather than on quantity.Key features of the MoRE2020 programme:• The programme covers incoming and outgoing mobility• There are no geographical restrictions regarding host research and innovation milieus abroad• The programme will be open to experienced researchers of all nationalities• The fellowships will be awarded for 12 months during a 24 months period• The applicant is an experienced researcher together with a research and innovation milieu in Västra Götaland • Only employment contracts, no stipends, are allowed• The programme allows research in a broad number of fields connected to smart specialisation areas in Västra Götaland• The applicant milieu in Västra Götaland co-finances approximately 25% of the fellowship, to ensure a strong commitment to the career development of the researcher and to the success of the project• Applications will be evaluated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Robotics UBIquitous COgnitive Network'.

assistant: **Innovation**

This project will create a self-learning robotic ecology, called RUBICON (for Robotic UBIquitous COgnitive Network), consisting of a network of sensors, effectors and mobile robot devices.<br/>Enabling robots to seamlessly operate as part of these ecologies is an important challenge for robotics R&D, in order to support applications such as ambient assisted living, security, etc.<br/>Current approaches heavily rely on models of the environment and on human configuration and supervision and lack the ability to smoothly adapt to evolving situations. These limitations make these systems hard and costly to deploy and maintain in real world applications, as they must be tailored to the specific environment and constantly updated to suit changes in both the environments and in the applications where they are deployed.<br/>A RUBICON ecology will be able to teach itself about its environment and learn to improve the way it carries out different tasks. The ecology will act as a persistent memory and source of intelligence for all its participants and it will exploit the mobility and the better sensing capabilities of the robots to verify and provide the feedback on its own performance.<br/>As the nodes of a RUBICON ecology will mutually support one another's learning, the ecology will identify, commission and fulfil tasks more effectively and efficiently.<br/>The project builds on many years of experience across a world-leading consortium. It combines robotics, multi-agent systems, novelty detection, dynamic planning, statistical and computational neuroscience methods, efficient component & data abstraction, robot/WSN middleware and three robotic test-beds. Validation will take place using two application scenarios<br/>Impact: The project will reduce the amount of preparation an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unlocking infectious diseases research potential at Riga Stradins University' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims at unlocking the research potential in the area of infectious, immunological and rare diseases at Riga Stradins University by establishing two new laboratories: a digital immunological visualisation laboratory and an infectious diseases modelling laboratory, and by up-scaling research personnel capacity by employing experienced incoming researchers. This will help facilitate integration into the ERA, accompanied by dedicated dissemination activities and two scientific workshops and one scientific conference. Strategic intellectual property development plan will allow the optimal management of intellectual assets at the University. Finally, EC delegated experts will assess achievements and competitive EU research entity status of the University in the area of infectious diseases research, promoting higher level participation in the  Horizon2020 programme, advancing contribution to Innovation Union flagship initiative and supporting European Innovation Partnerships.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Extending the scope of Reduced Density Matrix Functional Theory for bosons' (RDMFTforbosons) under Horizon Europe.

assistant: **Objectives**

The one-body reduced density matrix plays a fundamental role in describing and predicting general quantum features of bosonic systems, such as Bose-Einstein condensation (BEC) or mode entanglement. The recently proposed reduced density matrix functional theory for bosonic ground states establishes the existence of a universal functional that recovers quantum correlations exactly. So far, this novel theoretical framework has been used to study the universal properties of homogeneous BECs, to prove the existence of the so-called Bose-Einstein repulsive force, which explains quantum depletion in a geometrical fashion, or to efficiently compute well known ground-state properties of translation-invariant homogeneous bosonic systems. Our main purpose in this project is to extend the scope of this reduced density matrix functional theory to systems with broken symmetries, heterogeneous mixtures of bosonic systems, dipolar gases, and bosonic systems at finite temperatures. Our methodology combines analytical approaches and machine learning implementations, in which we have already gained strong expertise. We believe that the achievement of these objectives will offer a range of fascinating possibilities. Just to mention a few, any trap potential could be considered and linear response coefficients become easily accessible. Furthermore, in analogy to many-body localization for electrons, the influence of disorder and interparticle interactions on BECs can be studied in a more direct manner. Universal properties of dipolar gases and bosonic mixtures in the relevant regimes of supersolidity and droplets can potentially be unveiled.


**Keywords:** Reduced density matrices, non-perturbative approaches, highly correlated quantum systems, Bose-Einstein condensation, machine learning,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Attosecond nanoscopy of electron dynamics instrongly correlated materials' (ANACONDA) targeting Horizon Europe.

assistant: **Abstract**

In 1929, one year after the formulation of his world-famous equation, Paul Dirac wrote that ""the fundamental laws () of a large part of physics and the whole of chemistry are thus completely known, () but lead to equations that are too complex to be solved"". While Dirac was referring to analytical solutions to his equation, numerical approaches have made tremendous progress over the past century. Nonetheless, the so-called strongly correlated materials continue to defy a common experimental and computational access to some of their intriguing exotic properties in solids.In this proposal, I will investigate correlated transition-metal oxides, which undergo a phase transition upon external perturbation, such as temperature, pressure, strain or laser excitation. I will develop a unique table-top ultrafast soft-X-ray absorption and holographic imaging experiment. The measurements will follow the attosecond to picosecond dynamic switching between metallic and insulating phases after laser excitation of transition metal oxides with element-specific absorption measurements, and simultaneously spatially resolve the ultrafast emerging nanometer texture of the phase transition. The unprecedented measurement of attosecond nanoscale dynamics will enable to unambiguously identify the mechanism and ultimate speed of phase transitions.I will use the fundamental insight from attosecond nanoscopy to test the hypothesis, that structural and electronic IMTs coexist and can be steered through both sample engineering and attosecond light-field control, which will pave the way towards PHz oxide electronics. Controlling the currently absent spatial uniformity of phase transitions on the nanoscale and the concomitant order-of-magnitude resistivity changes are key ingredients to guide transit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Demonstration and dissemation of ECO-concepts for high- performing European cultural buildings' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This project addresses demonstration of energy efficient technologies integrated into three high- performing cultural ECO-buildings. All the buildings will be designed using a Whole Building Design Approach" in order to ensure the largest energy saving potential possible.The overall energy objectives of the ECO-CULTURE buildings are:- To reduce the energy consumption and C02 emission related to cooling by 75-80%- To reduce the heat consumption and related C02 emission by 35-50%- To reduce the energy for ventilation and related C02 emission by 35-50%- To use renewables! sea water, ground water and solar energy- To use intelligent control for maximised utilisation of the use technologies- To disseminate the used ECO-concepts of the high-performing cultural buildings"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Elucidating the Microscopic Origins of the Light-Induced Gating Mechanism in Channelrhodopsin-2'.

assistant: **Innovation**

Alzheimer's disease is the most common form of dementia. It affects millions of people and is expected to increase in the coming decades due to aging of the population. Optogenetics combines optics and genetics to gain insight into brain function by genetically inserting light-sensitive transmembrane proteins into neurons. Channelrhodopsin-2 (ChR2) is an ion channel protein that enables precise temporal control turning neurons on or off in response to light. In vivo optogenetic experiments have a number of complications. One such complication is related to the wavelength of the visible light needed to activate ChR2. This results in high scattering by biological tissue as well as competition with hemoglobin which absorbs at a similar wavelength. Activation by multi-photon absorption processes (i.e., simultaneous absorption of multiple photons of longer wavelength) has the potential to mitigate both effects. Another complication is that ChR2 becomes inactive after prolonged illumination. This is related to its intricate photocycle. Gaining a detailed understanding of the molecular mechanism of the complete photocycle is crucial for solving these complications. To this end, ENLIGHT will use a holistic approach that combines multiscale quantum-classical methods, molecular dynamics simulations, and statistical analysis to obtain atomistic insight into the photoactivation, kinetics, and thermodynamics of the ChR2 photocycle. The acquired fundamental understanding of ChR2 will thus enable the development of next-generation optogenetic tools that have the potential to help us better understand the brain and neurodegenerative diseases. Dr. David Carrasco de Busturia (DCB) will carry out this project supervised by Prof. Patrick Norman at KTH, and a secondment at EPFL with Prof. U
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'In cellular conformations of microRNA-34a via magnetic resonance' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

microRNA-34a (miR-34a) is mis-regulated in ~75% of cancers and is considered a promising drug target. In a recent clinical trial, miR-34a was used against terminal liver cancer showing promising result with remission of 3 patients. However, mortality remained high and was attributed to its ability to target multiple mRNAs. Project ECONOMICS will investigate this issue by elucidating the underlying structure and dynamics of multiple miR-34a:mRNA complexes using NMR spectroscopy and molecular dynamic simulations. This will provide information about the conformation of miR-34a which is mRNA specific. This can further be stabilized by mutations to increase target specificity of miR-34a leading to an improvement in clinical trial results. miR-34a targets and binds the 3’-untranslated-region (3’-UTR) of ~100 mRNAs via the RNA-induced silencing complex, resulting in downregulation of the associated genes. Recently, it was discovered that miR-34a attains a high energy excited state (ES) conformation for mRNA encoding gene SIRT1. Stabilizing this ES resulted in a two-fold increase in gene repression. Can miR-34a have a similar ES for other genes implicated in various cancers? This will be studied by exploring the structure and dynamics of miR-34a when complexed with 3’-UTR of the mRNA encoding the genes HNF4a, NOTCH1, NOTCH2, DLL1 and WNT1. Cellular environment is proposed to affect the ES of miR-34a, therefore a detailed conformational landscape of miR-34a:mRNA complexes will be mapped by comparing both in vitro and in live human cells (cancerous and non-cancerous). This study will provide targeting rules for microRNA within the cell and insight into its regulatory mechanism. This information will improve the efficiency RNA based drug development, giving a competitive edge to E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Building knowledge and  tools to advance on promoting of freshwater urban ecosystems as nature based-solution for health and wellbeing in a changing word' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cities around the world are undergoing significant transformations and are facing substantial challenges in the form of urban of climate change and ongoing urbanisation. The idea that we can work with nature to improve our cities is now seen as vital. The concept of Nature-Based Solutions has emerged to foster sustainable development by transversally addressing social, economic, and environmental urban challenges. Although the attention to nature-based solutions inclusion is an important pillar of urban sustainability, a clear understanding how they can be implemented in the freshwater landscape, is still missing, even in face of the relevance of the urban freshwaters to wellbeing of the population. This investigation aims to fill this gap, by analysing the social and environmental impacts of urban streams as important nature-based solutions from protecting water quality to reducing natural hazards while preserving biodiversity and providing health and wellbeing benefits to population. By selecting as case studies Aveiro and Coimbra, the research project aims to promote the urban streams and their multiple ecosystem services as important nature-based solutions to mitigate the effects of urbanization and climate change on aquatic ecosystems,  in the human health and in the wellbeing of the population. The project will adopt the research strategies: to assess how urban development affect a capacity of urban streams to provide ecosystem services using well-established scientific methods and  investigate how the degradation of urban streams reflects on the local residents perception of the ecosystem services in terms of benefits, health and wellbeing. In addition, thematic maps of ecosystem services identified in the urban streams will be produced to demonstrate the relevan