RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a new topic formulation of icrf-187 (dexrazoxane) for treatment of psoriasis' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Razoxane 5ICRF-159) has been shown to have clear dose dependent efficacy in treatment of patients with psoriasis refractory to other conventional therapies. In an attempt to improve the therapeutic index of Razoxane, i.e. maintening high efficacy and lowering the dose-limiting neutropenia, its detrox-enantiomereICRF-187 has been developed. It is known that doses up till 1/3 of MTD (maximum treatment dose) do not cause any significant drop in peripheral leukocyte counts. This project has been designed to determine the following:1. Confirmation of the efficacy and safety of i.v. administered, commercially available ICRF-187 (trademark CARDIOXANE in EU, ZINECARD in USA and CAN)2. Development of a new drug formulation: cream or ointment for topical treatment of skin lesions.3. Detailed study of pre-clinical and clinical efficacy of new formulation4. Development of pharmacological, toxicological and clinical documentation necessary to support registration in EU countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Accelerating the decarbonisation of islands’ energy systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Borkum is an island of about 30 km2 and 5,500 residents, located 20 miles from the north-western coast of Germany. Following concerns of the population regarding air quality due to a new coal fired power plant, Borkum started on a path towards renewable energy many years ago. Following several initiatives in that direction including a citizen dialogue, the island decided to become emission-free and fully decarbonized by 2030.Within this framework, the ISLANDER project will showcase the process of making Borkum a fully autonomous and decarbonised island energy system. Specifically, the project will focus on delivering:a) Distributed RESS systems (Renewable Energy + Small-scale Storage). b) Complementary short-to-seasonal, large-scale electricity storage.c) Seawater district heating coupled with heat storage and sized for 100 residential units, to make use of the heat of the North Sea water as a source of heating and cooling.d) Deployment of an EV charging network.e) A smart IT platform conceived to holistically perform the optimal aggregation of all these components while also implementing Demand Response (DR).f) An optimisation tool to optimally design zero-carbon island energy systems.To achieve such 2030 objectives of financing and maintaining the further roll-out of renewables and storage technologies across the island, the ISLANDER partners will facilitate the kick-start of a Renewable Energy Community in Borkum right during the project following a concrete roadmap.Additionally, and as part of an ambitious plan to replicate the project results, the partners have developed a 3-wave replication strategy including:Wave 1) Replication in the Follower islands,Wave 2) Replication in the related archipelagos.Wave 3) Further replication to the rest of EU islands.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pneumatic manipulator of sock lining for plastic boots controlled by fuzzy logic for the injection footwear industry' in the context of a Fourth Framework call.

assistant: **Objectives**

The footwear technology of plastic boots consists in the upper over a sock lining and then the moulding of the sole onto the upper by an injection machine, usually a rotary machine equipped with up to fourteen mould carriers. a workman provide to last by hand a pre-stitched sock lining on the aluminium last; the mould closes and the sole are directly injected. after a few minutes, the mould opens and the boot is delasted by the workman or by a manipulator. This job is very repetitive and tiring : a common problem of the boot makers is the continous potential danger of serious accidents that can occour to the workman that operates near the injection machine. This project is aimed to develop a pneumatic manipulator to be enslaved to the injection rotary machines for plastic boors which is able to last, stitch and cut a sock lining on a last simulting the human hands movements jumping the pre- stitching and cutting operation. The actual availability of the fuzzy logic and neural network make it possible to conceive a device able to last a sock lining without the human intervention. This project is aimed to develop a pneumatic manipulator to be enslaved to the rotary machine for plastic boots which is able to last, stitch and cut a sock lining directly on the last simulating the hands movements jumping the pre- stitching and cutting operation. The manipulator must be able to last different sizes and model of sock lining according to the daily program of production of the injection machine and to the moulds placed on the mould carriers. Furthermore, the manipulator must pay attention to the correct positioning and orientation of the sock lining on the last avoiding to leave creases that could be cause of reject boots. An adaptive control system appears to be ideal instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Social Sciences Participatory Research-Action for Preparedness in Risk Management for Disasters and Health Emergencies in Europe’s Cities'.

assistant: **Concept**

Disasters, including health emergencies, pose enormous strains on response capacities of cities, countries, and the European Union, compounding existing climatic, political, economic, and social challenges. The risks and consequences of these emergencies reduce the health and well-being of Europe’s inhabitants. But their burdens are not evenly shouldered across all populations. Cities face huge challenges in preparing for and responding to disasters: urban publics not only suffer higher morbidity and mortality during such emergencies but resulting instability and response measures can exacerbate social and health inequalities. Vulnerable urban inhabitants are at risk during such crises for exclusion and heightened health consequences. With lower access to health information, resources, care and support, they tend to experience higher mortality and morbidity and longer-term reductions in health. The goal of Sonar-Cities is to render Europe’s cities more resilient in health emergencies and disasters through the co-creation and implementation of a community-based, adapted toolset for people facing vulnerabilities, first responders, and decisionmakers. By strengthening inclusivity in risk management, we will enhance preparedness and reduce risks posed by these emergencies. We will analyze One Health factors and consequences of past emergencies in 6 European cities, notably from the perspectives of people experiencing vulnerabilities. We use these analyses to co-create with publics at risk, first responders, and authorities a citizen-centered toolset, which will generate inclusive preparedness, improve health literacy and crisis communication, strengthen capacity and decision-making, and reduce risks of disasters/health emergencies in European cities. We will disseminate the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'AQUALABS - Advanced Laboratory Training Courses in Aquaculture for Early-Stage Researchers'.

assistant: **Concept**

AQUALABS consists of seven events, six state-of-the-art advanced courses for early-stage researchers emphasising the acquisition of practical skills and incorporating a substantial element of hands-on laboratory and field experience, with the seventh event being an innovative multidisciplinary workshop. Each training course is a collaborative effort between four or more European universities, facilitating up to 30 participants at centres recognised for expertise.Training course titles: (1) Quality of Fish P roducts, (2) Molecular Biology and Ecology, (3) Design and Operation of Recirculation Technologies, (4) Aquatic Animal Disease Diagnostics, (5) Freshwater Aquaculture and the Environment, (6) Fish Welfare.The series of events will conclude with the ?Early-Stage Researchers Workshop?, held in conjunction with the largest European Aquaculture industry tradeshow and conference for added value. The workshop aims will be three-fold: 1. Examine scientific content (relative to course title), prediction of future n eeds2. Review of current and potential future research issues3. Acquisition of non-research competencies. The workshop will enable researchers to develop synergies, collaborate and, in particular, allow early-stage researchers to engage in debates regardin g the sustainable and ethical development of the sector whilst developing complimentary skills required for a successful research career.Coordination by AquaTT, a European network for education and training, will ensure cost effective, efficient management , publicity and dissemination. AQUALABS targets early-stage researchers working in aquaculture; however, the multidisciplinary nature of the courses will appeal to scientists from related fields. Each course will consist of three periods: 1. Preparation: centr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Politics of difference: Child marriage and prestige consumption among the Romanian Gabor Roma – with a special focus on the post-socialist transformation' (PDCMPCARGR), addressing dissemination and exploitation.

assistant: **Impact**

The project focuses on the practices and ideologies of the politics of difference (in Ŕomani language: Ŕomani politika ‘Roma politics’) characteristic of the Gabor Roma living in Romania. Roma politics is a tournament of value serving to construct, represent and manipulate social and economic differences. The prestige relations between Gabor Roma individuals and families are primarily defined on the basis of the results achieved in the ethnicized, symbolic arenas of Roma politics. The project pays special attention to two of these symbolic arenas: prestige consumption and marriage politics based on child marriage. It reveals that in order to obtain a deeper and more context-sensitive understanding of the social relations and interactions in Roma groups it is necessary to simultaneously investigate the politics of difference and the ethics of sociability, and how they impact each other. One of the central questions of this multi-disciplinary research is how the post-socialist transformation has affected these symbolic arenas and the pre-revolution Gabor Roma concept of social success.Today, child marriage within Roma groups is a social problem found throughout Europe. (See the statement of the European Parliament published in March 2013: http://www.plan-eu.org/pressrelease/european-parliament-turns-spotlight-tackling-child-marriage/). Since Gabor Roma—referring to their own cultural autonomy—insist on child marriage, which is prohibited under EU regulations, a complex conflict of law and value has evolved. The research—which can be defined as a type of cultural brokerage—can significantly contribute to a detailed understanding of this symbolic conflict between Roma customary law and EU laws, as well as possible solutions. In this way, the research findings will be useful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Association for Research in Industrial Economics - 2001 Annual Conference' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The annual conference of the European Association for Research in Industrial Economics is the principal vehicle for dissemination of results and discussions of international developments at a European level in the area of Industrial Economics.This annual event brings together the top academics and researchers in the European arena, and provides a forum for presentation by young researchers. The 2001 conference is being held in Trinity College Dublin, Ireland, and will have presentations from 150 contributors including 3-6 keynote speakers and 50 young researchers. Contributors will be selected for the quality and relevance of their paper through a rigorous assessment procedure.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00111-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of novel viral entry factors and development of antiviral approaches' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

DEFENDER will address the need for innovative intervention strategies against viruses with epidemic potential, by adopting a comprehensive and integrative platform approach. DEFENDER’s revolutionary Research and Innovation pipeline will focus on preventing virus entry through a host-directed bottom-up approach based on functional genetics in parallel to a top-down virus glycoprotein-centered approach. We will identify novel host dependency and restriction factors, including receptors and proteins involved in viral attachment and binding, endosomal uptake and virus genome uncoating, as targets for antiviral therapy. In parallel, we will use recombinant viral glycoproteins to identify broadly neutralizing nanobodies and novel epitopes for the AI-based design of next generation immunogens and the improvement of therapeutic antibodies. The host bottom-up functional genetic approach will be applied to Nipah, Lassa, Zika, Dengue, Yellow fever, and Chikungunya viruses. Host factors will be identified using a unique arrayed CRISPR perturbation platform, combined with advanced statistical and machine learning approaches and mathematical modelling, mechanistic experiments, and cutting-edge imaging techniques. In parallel, the virus top-down glycoprotein-centered approach will lead to the identification and structural characterization of broadly neutralizing nanobodies targeting conserved epitopes of the glycoproteins of Nipah and Lassa viruses in pre-fusion conformation. DEFENDER will deliver innovative antiviral candidates that induce target degradation, next generation immunogens, and a novel concept to improve the activity of therapeutic antibodies, with proof-of-concept preclinical evaluation in mice. It will define the most vulnerable virus-host interactions, to deliver a ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Directed Evolution of Nonribosomal Peptide Synthetases (NRPS) Using the Novel BeSD Screening System' (NRPS), addressing dissemination and exploitation.

assistant: **Impact**

Nonribosomal peptides are a highly important class of natural products and display a broad spectrum of bioactivity, ranging from antimicrobial and immunosuppressant to anticancer. They are synthesized by non-ribosomal peptide synthetases (NRPSs), a diverse group of large multifunctional enzymes that operate as molecular assembly lines. They consist of modules that are responsible for coupling, processing and modification of an extending chain of amino acid monomers, heterocyclic rings and N-methylated residues. Re-programming of these unique biosynthetic routes should lead to a range of novel products of pharmaceutical importance. Previous studies which have focused on module swapping led to so called chimeric assembly-line enzymes. However most of those chimeras are heavily impaired due to the drastic changes applied, which could partially be compensated by site directed mutagenesis (SDM). SDM was also used to directly alter the specificity of several domains (e.g. the A-domain of TycA). Still no high throughput in vitro assay to evolve NRPS systems is available. We will therefore adapt the Megavalent Bead Surface Display (BeSD) system that has recently been developed for the directed evolution of protein binders to monitor peptide forming reactions by C-domains. In contrast to widely-used in vivo systems (such as bacterial, phage and yeast display) it is able to deal with larger library sizes and is not limited by host compatibility. BeSD will be the first in vitro system that is able to rank enzymes according to their bond forming efficiency since it can be coupled to fluorescence-activated cell sorting (FACS). Finally variants with altered specificities will be incorporated in modular assembly lines. This work will open the road to analyze larger, more diverse libra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Systematic discovery of functional elements in RNA virus genomes: an Encyclopedia of RNA Virus Elements' (ERVE) under Horizon 2020.

assistant: **Objectives**

Identification of the full complement of genes and other functional elements in any virus is crucial to fully understand its molecular biology and guide the development of effective control strategies. Our recent discoveries of new 'hidden' genes in the potyviruses, alphaviruses, arteriviruses, flaviviruses and influenza A virus have demonstrated that, even in the most well-studied and economically-important viruses, small overlapping genes can remain undetected throughout decades of research. Comparative computational analyses can be used to efficiently identify hidden features and target experimental analyses, thus saving time and cost, and minimizing animal experiments. With the rapid increase in sequencing data, for the first time it is now possible to map out at high resolution functional elements genome-wide in hundreds of important virus species.Our research involves the development of powerful new tools for virus comparative genomics, and the application of these tools to uncover hidden genes and other functional elements in RNA virus and retrovirus genomes. Hidden genes are often translated via non-canonical mechanisms, such as programmed ribosomal frameshifting, and we are particularly interested in discovering and characterizing new types of non-canonical translation. Deciphering these 'exceptions-to-the-rule' enhances our understanding of the mechanics of protein synthesis. Further, these novel mechanisms may also be relevant to cellular gene expression.The goals of this project are:1) To computationally identify all 'hidden' genes and major functional non-coding elements in the genomes of RNA viruses and retroviruses of medical, veterinary and agricultural importance.2) To experimentally characterize the most interesting new features.3) To characterize nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Status and Trends of European Pollinators' (STEP).

assistant: **Concept**

Pollinators form a key component of European biodiversity, and provide vital ecosystem services to crops and wild plants. There is growing evidence of declines in both wild and domesticated pollinators, and parallel declines in plants relying upon them. STEP will document the nature and extent of these declines, examine functional traits associated with particular risk, develop a Red List of some European pollinator groups, in particular bees and lay the groundwork for future pollinator monitoring programmes. We will also assess the relative importance of potential drivers of such change, including climate change, habitat loss and fragmentation, agrichemicals, pathogens, alien species, light pollution, and their interactions. We will measure the ecological and economic impacts of declining pollinator services and floral resources, including effects on wild plant populations, crop production and human nutrition. STEP will review existing and potential mitigation options, providing novel tests of their effectiveness across Europe. Our work will build upon existing datasets and models, complemented by spatially-replicated campaigns of field research to fill gaps in current knowledge. We will integrate our findings in a policy-relevant framework, creating Evidence-based Decision Support tools. We will also establish communication links to a wide range of stakeholders across Europe and beyond, including policy makers, beekeepers, farmers, academics and the general public. Taken together, our research programme will make great steps towards improving our understanding of the nature, causes, consequences and potential mitigation of declines in pollinator services at local, national, continental and global scales.