RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanical Aspects of Hydra Morphogenesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Morphogenesis is one of the most remarkable examples of biological pattern formation. Despite substantial progress in the field, we still do not understand the organizational principles responsible for the robust convergence of the morphogenesis process, across scales, to form viable organisms under variable conditions. We focus here on the less-studied mechanical aspects of this problem, and aim to uncover how mechanical forces and feedback contribute to the formation and stabilization of the body plan. Regenerating Hydra offer a powerful platform to explore this direction, thanks to their simple body plan, extraordinary regeneration capabilities, and the accessibility and flexibility of their tissues. We propose to follow the regeneration of excised tissue segments, which inherit an aligned supra-cellular cytoskeletal organization from the parent Hydra, as well as cell aggregates, which lack any prior organization. We will employ advanced microscopy techniques and develop elaborate image analysis tools to track cytoskeletal organization and collective cell migration and correlate them with global tissue morphology, from the onset of regeneration all the way to the formation of complete animals. Furthermore, to directly probe the influence of mechanics on Hydra morphogenesis, we propose to apply various mechanical perturbations, and intervene with the axis formation process using external forces and mechanical constraints. Overall, the proposed work seeks to develop an effective phenomenological description of morphogenesis during Hydra regeneration, at the level of cells and tissues, and reveal the mechanical basis of this process. More generally, our research will shed light on the role of mechanics in animal morphogenesis, and inspire new approaches for using extern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Wool Age: rethinking social life in later prehistoric Europe' in the context of a Horizon Europe call.

assistant: **Objectives**

The story of European prehistory is written in durable materials – stone, bronze and iron define the major archaeological periods and are taken to have shaped corresponding societies. Perishable materials, such as wool, have comparatively little impact on our understandings. However, wool production is highly demanding on societal and economic organisation and produces its own embodied experiences through seasonal production cycles. The earliest domesticated sheep had a hairy fleece, unsuitable for spinning into yarn, so the arrival of wool-bearing sheep fundamentally reorganised pastoral life: requiring novel husbandry practices (plucking/gathering shed wool, castration to increase quality, etc.) and huge investment in yarn/textile production. Its adoption in Bronze Age Europe has even been termed a ‘revolution’ (Sabatini & Bergerbrant 2020), bringing a new material with unique insulating properties, new ways of expressing identities, and new forms of human/animal interaction. Critically, the timing of this process appears to be uneven. The earliest evidence for wool in Britain is the Rylstone textile, dated to 840–590 BC, while Danish examples, for instance, occur from 1700 BC. This is curious given a known rise in sheep numbers in Southern England throughout the second millennium BC. Could wool really be absent from Britain while revolutionising Europe? ‘The Wool Age’ will define the emergence and growth of the prehistoric wool economy in Britain for the first time and characterise the societal consequences. This will be achieved through a novel triangulation of available evidence (animal bone reports, textile tools, and landscape organisation) which avoids waiting for the chance survival of delicate textiles. Thus, a critical issue to our understanding of societal o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Enantioselective screw-dislocation-mediated growth of chiral nanocrystals'.

assistant: **Objectives**

In many scientific disciplines structural symmetry considerations are key. Specifically, mechanisms by which symmetry translates from atomic and molecular building blocks to crystal structures and shapes attract a great deal of attention. A fascinating aspect of this is related to chirality. Louis Pasteurs monumental work, reported in 1848, on formation of chiral shapes in crystals made from chiral molecules, led to an intuition that chiral building blocks naturally lead to chiral shapes in crystals. Yet, after countless observations ever since of crystals with chiral shapes, mechanisms of their formation are understood to be often more complex and elusive than first imagined. In work proposed here, nanocrystals will serve as convenient model systems for studies of the interplay between crystallization and chiral shape formation. They are beneficial for this purpose as they can mimic embryonic stages of crystal growth, exhibiting structural details that can be retrieved at remarkable resolution, that are often hidden in macroscopic crystals. Specifically, I will focus on a universal mechanism by which crystals grow at low concentrations of building blocks, assisted by a common type of imperfections, namely, screw dislocations. I will tackle key unresolved questions on the interplay between chirality, screw dislocations and crystallization. First, how does screw-dislocation-mediated growth proceed in the presence of chiral additives that can bind to growing crystals, and how do these dislocations even come to be? Second, how general is this mechanism, and how often was it overlooked throughout history? The results obtained in this work, on the one hand, will lead to a general design principle to control nano-scale chirality in many inorganic materials, beneficial for nov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding the Caspian sea erratic fluctuations' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Foreseen ResultsThe project will be coordinated from France. Organization and management will include a Coordination Workshop" at the early beginning of the project, and an "Evaluation Meeting" at mid-project. Several visits of the Coordinator proposer at every other proposer's institutions are an absolute must, to follow monitor partners' activities. Active inter-countries exchanges are also planned to develop synergies between partners, especially in the final, interpretative phase of the project.As final results, a better understanding of processes operating on the Caspian Sea level fluctuations will enable substantial progress towards scientifically validated forecasts of climate- and/or geology-induced environmental changes for the near and remote future.The Caspian Sea is of crucial economic importance for its 5 surrounding countries. Sudden water level changes cause great damage to industrial and agricultural facilities, fisheries, and coastal settlements. There is no satisfactory explanation of the Caspian Sea water level fluctuations. Apparently, climate plays a dominant role, but geological and anthropogenic factors may also come into play.In order to improve the future change predictability, we propose a multi-disciplinary, comprehensive approach of the complex processes acting on the Caspian Sea. Compared to previous investigations in the field, three innovative aspects are proposed in our project :(i) a geochemical approach of the modern budgets(ii) high temporal resolution statistical analysis of the past, over time windows (100 to 1000 years) large enough to exhibit many fluctuations comparable with the recent ones. This will provide the necessary time series for analysis of short-term changes timing, duration and amplitude(iii) testing the impact of pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Genomics of Feralisation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Feralisation is a complex process that occurs when a domestic population is returned to the wild. It impacts species invasion biology, speciation, conservation and hybridisation and can be thought of as the reverse of domestication. Domestication has been an area of intense interest and study ever since Darwin, and useful as a model for evolution and the effects of strong directional selection. This project will identify underlying genes and mechanisms of trade-offs and adaptations surrounding feralisation, by integrating population genetics, genome-wide association and functional genomics in a parallel (previously developed/established) feral and laboratory chicken system. Despite domestication being used to identify genes affecting a large number of traits that change with selection, almost nothing is known about the genomic changes associated with feralisation. The process of feralisation involves the sudden return of both natural and sexual selection; such forces influencing predatory, foraging and mate choice decisions, exerting strong effects on a once domesticated, now feral, population. As such, feralisation provides a unique opportunity to observe the genomic response to selection from a known (domesticated) standpoint, and identify the genes underlying these selective targets. The combination of feralisation with domestication provides a powerful tool to address a multitude of important questions currently predominating the field of biology. How do gene polymorphisms affect small-scale quantitative variation, particularly in wild population? How does the genome respond to selection, and how can (cryptic) variation be maintained and increased in the face of this selection? What mechanisms underlie gene and organismal trait variation. Feralisation combines the a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Alpha Nanotherapy to Target Metastatic Cancer' (AlphaTar).

assistant: **Innovation**

Targeted alpha therapy, a treatment that relies on targeting pharmaceuticals labeled with ⍺ emitters, has produced complete cures of metastatic cancer patients with refractory diseases in clinical trials. However, targeted alpha therapy is limited by the release of radioisotopes from the pharmaceuticals. In ⍺ emissions, the decay products break the chemical bonds by which they are bound to the radiopharmaceutical, and once liberated, they spread all over the body, causing off-target radiopoisoning. Thus, preventing radioisotope release is a fundamental step to improve targeted alpha therapy safety and extend its use beyond terminal cases. In AlphaTar, I will completely change how ⍺ emitters (particularly 212Pb) are delivered to metastatic tumors. This will be done by developing a novel therapeutic regime that employs targeted ultra-small nanoformulations as carriers. These nanoformulations will conceal the radiometals and their decay products and minimize side effects, while displaying enhanced therapeutic activity. Most clinical nanomedicine formulations are large (>50 nm) and display long-term accumulations in the liver and spleen, making them unsuitable for targeted alpha therapy, since those cause radiopoisoning. My approach will rely on formulations with sizes below the renal clearance cutoff (<10 nm), which can be rapidly and completely excreted through the urine with minimal off-target accumulation. Imaging-based strategies will be developed to identify patients who are likely to respond to AlphaTar, and genomic screening will be performed to assess safety. Local and systemic responses will be improved via combination therapy with immune checkpoint inhibitors, and physical and pharmacological priming will be used to enhance nanomedicine extravasation, penetration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New methods for new materials' (NEW4NEW).

assistant: **Concept**

Computational modelling of molecules and materials has had a great impacton understanding experimental observations and suggesting new routes fordevelopment. A prominent example are chemical reactions where modelling allows one to follow the motion of atoms and to obtain a detailed insight into the process.To model chemical reactions, quantum mechanics for electrons is neededand currently the most widely used method for this task is Kohn-Shamdensity functional theory (DFT). DFT is exact in principle, but in practice, different approximations are made. These approximations affect the accuracy of description of both strong intramolecular forces (chemical bonds) and weaker intermolecular interactions (e.g., van der Waals forces).If the errors are significant, one can obtain misleading results.Systems where an accurate description of both strong and weak forcesis crucial are molecules in porous materials, such as zeolites.Zeolites are important industrial catalysts and also perspective materialsfor gas separation. During the catalytic process, molecules interact first weakly with the zeolite before chemical reaction takes place.Therefore, if we want to further improve the function of porous materialsor develop new ones with desired chemical activity, we need to be able tomodel reliably both strong and weak forces.It is the goal of this project to develop new reliable methods that willenable the development of new materials. This goal will be accomplished by combining state-of-the-art DFT approximations for modelling strong and weak interactions and implementing promising schemes recently proposed.Using the expertise of the host group, we will use data available for zeolites and molecules in zeolites to validate the methods and understand their accuracy.The ability to model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ultra-Cold Nano-Mechanics: from Classical to Quantum Complexity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Nano-electro-mechanical devices (NEMS) are extremely small objects that can be actuated and detected by electric means. They are in the first place transducers that can be used as probes for forces down to the molecular level. Top-down fabricated NEMS using conventional microelectronics techniques are simple devices that intimately link mechanical and electrical degrees of freedom. As such, they can be viewed as model systems from basic (linear) harmonic motion up to complex nonlinear dynamics.The most intriguing experimental situation is attained when the devices are cold enough to behave according to the laws of quantum mechanics, instead of classical physics. This leads to a unique approach of the classical-to-quantum crossover with truly macroscopic position-states. Complementarily, at low temperatures the forces sensed by the NEMS arise from materials themselves cold enough to exhibit exotic quantum properties, originating either in the devices’ constitutive amorphous materials and their intrinsic elusive Tunneling Systems, or from their interaction with a sophisticated fluid like superfluid 3He.I propose unique research linking ultra-low temperature physics and nano-mechanics, building on my knowledge of both fields and my experience in superconducting quantum circuits. The research has two identified axes, which aim at pushing both the “sensor” and “model system” aspects of NEMS down to their quantum retrenchments. Macroscopic quantum position-states can be engineered with a hybrid quantum circuit arrangement (a combination of NEMS, microwaves and quantum bit), while topological states of confined superfluid 3He with their elementary excitations can be mechanically probed by dedicated NEMS (measuring friction). The scientific impact of this research is extremely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MAgneto-elastic coupling eXploitation in Bulk Acoustic Resonators' (MAXBAR).

assistant: **Innovation**

There is an ever increasing amount of data that needs to be transmitted, processed, and stored by mobile communication technologies like today’s smartphones and tomorrow’s numerous connected devices. Presently, the raw measurement signals need to be amplified, pre-conditioned, and converted to digital signals before they can be processed. Thus, there is clear impetus to supplement next generation radio technologies with analog signal processing functionalities to perform computation directly on the measured signals. By conducting research at the interface between nanomagnetism, acoustics, microwave engineering and micro-electromechanical systems, MAXBAR aims to integrate low power spin-wave signal processing capabilities with state-of-the-art acoustic wave resonators widely used in RF communication systems to distinguish between signals at different frequencies. It is motivated by the premise that the coupling between spin-waves and acoustic waves in nanosystems can be leveraged (i) to overcome the intrinsic limitations plaguing acoustic wave technology, and (ii) to simultaneously deliver an energy efficient microwave interface for spin waves – the holy grail of magnonics. The primary objective is to establish a platform in which strongly hybridized magneto-elastic resonant modes enables new technological functionalities, such as the tunability of bulk acoustic wave filters and the development of non-reciprocity in acoustical wave based delay lines.  The project builds upon the host institution’s expertise in microwave measurements of spin-wave propagation, interference processes and magnetization dynamics, while relying on next-generation acoustic wave resonators developed at the secondment institute to demonstrate its objectives. The applicant is an expert in the desi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Conducting Liquid crystal Elastomer ActuatoRs'.

assistant: **Innovation**

The overall goal of this cross-disciplinary project is to combine stretchable electronics with soft robotics in order to build up a novel materials platform that possesses multifunctional electronic control, sensing, and signaling coupled with actuation in response to environmental stimuli, such as electricity, heat, and light. In recent years the transformation of electronics into soft and stretchable organic systems has opened up a wide range of novel applications, including healthcare monitoring with ultrathin skin-like flexible devices, whereas actuators composed of soft active materials possess characteristics for microrobotics that are nearly impossible to achieve with conventional rigid systems, most notably mechanical compatibility with biological tissue. In this project interpenetrating conducting polymer networks will be fabricated in an actuator composed of a liquid crystal elastomer, a class of materials that has undergone rapid development within the past decade and is considered one of the best candidates for microscale soft robotics. The stimuli-response of the actuator brings about possibilities towards autonomous action, where it can sense the environment and act accordingly, representing multifunctional materials where the matrix has an active role in functionality. The unique combination of properties and functionalities promises coupled sensing and actuation that could have a transformative impact on the use of liquid crystal elastomers in soft matter applications. I envision that the conducting actuators have future applications as wearable sensors for heart rate detection and electrical nerve stimulation, with the reversible shape change enabling them to smoothly envelop around the target tissue.


**Keywords:** Liquid crystal elastomers, soft robo