RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Eco-Evolutionary Rescue of Fragmented Populations'.

assistant: **Innovation**

Here I will establish eco-evolutionary rescue analyses as a predictive science. I will do this by developing theories, principles and tools for assessing whether populations can cope with changes in the environment at both short (ecological) and long (evolutionary) timescales. I contend that analyses involving the capacity of organisms to adapt to environmental changes must be based on theories including realistic ecological assumptions. My aim is therefore to develop a common theoretical framework for analyses of eco-evolutionary dynamics that includes basic features that characterize almost all natural populations, such as stochastic fluctuations in population size, density-dependent feedback mechanisms and dispersal among geographically separate populations. I will be able to achieve this ambitious goal because I have recently been involved in developing a new set of theories that have identified novel quantities based on general ecological characteristics that eco-evolutionary processes tend to maximize. These provide objective measures of a population’s capacity to change, which can be used to assess the consequences of habitat loss and changes in environment variation such as those expected due to climate change. I will be able to parameterize these models via my access to one of the largest individual-based long-term field studies of any vertebrate species including data of more than 36000 individual house sparrows from 18 populations on islands within a large geographical area of northern Norway, which will enable me to quantify processes rarely analysed before in natural populations. A central focus will be to derive new metrics that describe how the degree of persistence of a population to environmental change depends upon its size and population dynamic chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a strategy to treat limb-girdle muscular dystrophy (LGMD2A) using combined cell and gene therapy strategies' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In Duchenne muscular dystrophy, several mutations can be corrected by the exon-skipping technique on cells. In limb-girdle muscular dystrophy type 2A (LGMD2A), however, all the mutations described to date do not seem to be good candidates for the RNA correction technology. The recently identified c.1782+1072 G>C mutation in LGMD2A patients could be potentially repaired at RNA level. The principal aim of this project is to mask the effect of this mutation in stem cells from patients that can be derived to muscle and to test its therapeutic potential in a mouse model. This is the first step to be considered before planning a clinical trial in patients with this mutation. Our long term goal is to generate new advanced therapy protocols (gene and cell therapies) against LGMD2A, a muscular dystrophy that is specially prevailing in the population of the Basque region. To this end, we will pursue the following aims: 1. To develop a therapeutic approach for LGMD2A patients who carry c.1782+1072G>C mutation. 2. Isolation, optimization of the in vitro culture and genetic correction of CD133+ cells from patients with this mutation. 3. Analysis of the efficacy of this combined therapeutic approach in murine models in vivo. In order to accomplish aims 1 and 2, we will develop a descriptive study with fibroblasts (from skin) and CD133+ cells (from blood and muscle) from donors, in which we will determine the efficiency, yield and myogenic potential for subsequent testing in mice. To accomplish aim 3 we will perform a double blind experimental approach in mice (wild type versus C3KO/scid and mdx/scid mice), using CD133+ cells with the most myogenic potential (from aim 2) as an in vivo therapy to determine the correction effect in the human calpain 3. This work would contribute to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrating Diversity in the European Union' (InDivEU), addressing dissemination and exploitation.

assistant: **Impact**

The challenge of Integrating Diversity in the European Union, InDivEU, is back on the EU agenda as it strives to forge a post-crisis future, respond to Brexit and reach out to European citizens. Europe’s Union has been under assault from populist political entrepreneurs who have mobilized distrust of and opposition to the EU. Hence the urgency of building the next phase on solid foundations. Differentiated integration (DI) is a compelling issue in deliberations on the Future of Europe.InDivEU has built a consortium of some of Europe’s premier research universities and outstanding scholars of DI to address the challenges facing the EU and commits to supplying robust evidence to support policy.The aim of InDivEU is to create a comprehensive knowledge base on DI of relevance to Europe’s policy makers. This work will have a direct impact on the work of AFCO in the EP, the Commission planning unit, prime ministers offices, European Affairs Committees and numerous civil society nodes.InDivEU will: 1. produce a comprehensive reappraisal and re-assessment of DI; 2. develop and test a range of models and scenarios, based on a catalogue of design principles, for the future use of DI; 3. create a DI Manual to support policy makers in designing future DI solutions; 4. evaluate existing policy proposals for DI and draft proposals for DI and other forms of flexibility as an input into the European debate based on four InDivEU unique data sets, tool kit and scenarios.The project’s foundations are built by establishing the normative criteria for a fair system of DI and by critically analysing the constitutional and institutional architecture of DI. InDivEU will complete two unique data bases, EUDIFF 1 & 2, on the uses of DI and two data sets on public opinion and flexible implementatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Internal dosimetry - enhancements in application' (IDEA) under Fifth Framework.

assistant: **Objectives**

Workers in the nuclear industry and members of the general public are exposed to ionising radiation, both from sources external to their bodies as to radionuclides incorporated into their bodies. The monitoring of such internal radiation exposure is less accurate and more tedious than external radiation monitoring. This proposal aims at enhancements in application of internal dosimetry to increase both the accuracy and the speed of internal exposure monitoring techniques. Methods that could improve internal monitoring, but whose applicability for routine application has not been demonstrated sufficiently are investigated. Better in vivo and bioassay monitoring techniques are the final goal of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Adhesion and Cohesion at Interfaces in High Performance Glassy Systems'.

assistant: **Concept**

The present project aims to establish a European Consortium bringing together leading experts in the fields of computational materials modelling, experimental materials research and industrial development of high-performance glass materials. The scientific and technological activities of the consortium shall be devoted to improving the efficiency, functionality and reliability of glass products for pharmaceutical and thin-layer optical and photovoltaic applications. The scope of the work will be to gain a detailed, atomic-scale knowledge of chemical and physical processes taking place at glassy interface systems. The Consortium will further develop a recently proposed atomistic modelling method which spans across multiple time and size simulation scales bridging the quantum-mechanical with the classical level of precision. The method will be applied to two scientific problems which require quantum precision and very large model system sizes. We will investigate (i) the adhesion between a glassy SiO2 phase and a protein-containing water solution, relevant to pharmaceutical applications and (ii) the cohesion between a glassy SiO2 phase and a TiO2-based coating layer, relevant to thin-layer optical or photovoltaic applications. The theoretical work will be carried out in close coordination with experimental activity. Novel materials will be designed and implemented into product prototypes within the R&D infrastructure of a leading European glass-producing company on the basis of the acquired knowledge. Our results will be disseminated through scientific papers, workshops and training activities especially designed for members of the industrial sector as well as for the scientific academic community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'European Education in Haematology'.

assistant: **Concept**

Aim : to develop a comprehensive approach to training in Hematology integrating new knowledge in genomics, immunology, genetics, pharmacology and human sciences. The explosion of new avenues of research in Hematology and the position of Europe at their for efront justify high level training at the pan-European level. The rapid, substantial geographic expansion of Europe calls for determined effort to ensure transfer of knowledge, to harmonize high quality procedures and to integrate in-coming countries in th e European research area. This project aims to significantly augment the number and quality of researchers in Europe and its Associated states, and to catalyze translational research synergies, notably between academia and industry. It anticipates forthcom ing needs at several levels : ? International competitiveness of experimental & translational research ? Pan-European coordination of clinical research ? Accessibility to training for researchers, including from in-coming EU states ? Development of new diagnostic & therapeutic tools with European industry ? Development of new organizational & technological tools, including accreditation schemes & guidelines for their use at the European level ? Consideration of new societal, ethical, regulat ory issues & development of health-related Science, Technology Reference (STR) ? Development, implementation & evaluation of new training tools. High level training and progress in these fields will attract younger scientists to Europe, thereby imp roving the quality of the European research area and associating younger scientists with its design and content. The European School of Haematology will organize these events. Attendees will include junior and senior scientists from academia and industry, including SMEs. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Seagrass Carbon cycling and Local Environmental Drivers' in the context of a Horizon Europe call.

assistant: **Objectives**

Seagrass meadows have been identified as hotspots for carbon (C) sequestration, however, their full  sequestration potential and its response to global change remains poorly understood and quantified. Large temporal and spatial variability of reported seagrass meadow carbon cycling rates limit our ability to robustly estimate seagrass meadows contribution to the global carbon cycle. With the SCaLED project, I will combine ecological, biogeochemical and modelling methods to develop a mechanistic understanding of seagrass meadow carbon cycling and sequestration, which will elucidate the observed variability, and thereby, enable robust present-day estimates and future forecasting of seagrass meadow carbon cycling. During the SCaLED project, I will receive training in the state-of-the-art Eddy Covariance technique, which I will apply alongside an ecological field survey, to quantify the dominant drivers of seagrass meadow carbon cycling. Using predictive and spatial modelling, I will make mechanistic regional forecasts of present-day seagrass carbon cycling, which will provide vital information for coastal managers and will help inform regional climate change policies. To further advance our mechanistic understanding and to forecast the future of seagrass meadow carbon cycling under climate change scenarios, I will conduct a secondment with ecological and biogeochemical modellers where I will develop an innovative dynamic seagrass carbon cycling model. The proposed interdisciplinary approach constitutes an unrivalled opportunity to increase our understanding of carbon cycling in the coastal zone and will provide me with a novel skillset that will set me up as an independent and innovative researcher.


**Keywords:** Seagrass, blue carbon, carbon sequestration, climate chang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BIogeochemical cycles, Sea Ice and CLimate in the Polar Oceans' (BISICLO).

assistant: **Innovation**

Recent field studies indicate an active biogeochemistry within sea ice. The latter is characterized by significant primary production, large loads of iron, and fluxes of climatically significant biogases, namely carbon dioxide (CO2) and dimethyl-sulfide (DMS). The role of sea ice in the carbon cycle and climate system via a large-scale action on ocean biogeochemistry is relatively poorly studied, potentially important and missing in Earth System Models.In this project, it is proposed to explore this role, in particular via an impact on carbon and iron cycles. The specific contribution of the relevant processes on carbon production and export at depth – be those processes physical (light, vertical mixing) or biogeochemical (nutrients, release of micro-algae, iron, heterotrophic feeding) – will be studied. In addition, an attempt to quantify the uncertainties associated with under-sampling and poor understanding of the processes involved will be made.The proposed analysis relies on a synthesis of existing observation data in both Polar Regions, on the development of numerical modeling tools, and on the analysis of numerical simulations both at local and global scales. In particular, the role of the specific processes at work will be studied via sensitivity experiments. The modeling tools include: (i) a one-dimensional sea ice model for the study of local-scale processes and (ii) NEMO, a numerical modeling system of the blue, white and green ocean (ocean, sea ice, and biogeochemistry) at large scales. As this ocean modeling system is part of a state-of-the-art climate model, it will be further possible to evaluate the role of sea ice on carbon cycle and climate.The project should take part into the reduction of uncertainties on climate and carbon cycle-climate projections
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Adaptive Robots for Flexible Manufacturing Systems' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The project objectives aims to radically innovate industrial robots in different application contexts. The design objectives will be demonstrated in real operating conditions. Increase in flexibility and adaptability, cost reduction and increase of the field of applications in the job floor, will be obtained by developing the needed know how and experimental evidence for new generations of high performing embedded control systems. This will require to integrate - in dedicated hardware and software subsystems and components - the most advanced base technologies and a new class of control techniques. Lower cost will be assured by choosing a soft/hard flexible standard architecture with optimal compromise between standard components and interfaces, and the use of deeply integrated components. The control system will differ from existing solutions (top-down open-control of the arms joints) for the type of control technology used and the level of component integration. A higher level of control will be added to close the control chains, feeding back information from added environmental sensory devices. Disparate technologies will be investigated and integrated in end-user industrial scenarios: topics include control theory, video sensors, integrated circuits, visual processing algorithms, sensors fusion, communication networks, middleware software packages, real time operating systems, and robot design. The project will therefore also represent a challenge to the present knowledge in all those disciplines, feeding back important information for their advancement. The project approach, leveraging on existing research and standardization efforts and on results already in place in the robotic industry, will guarantee enough flexibility for exploitation and adoption in the large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Responsible Ethical Learning with Robotics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

REELER - Responsible Ethical Learning with RoboticsRobots are the next ICT-related technology on the horizon ready to radically alter human societies. It is a major societal concern that up to 40% jobs may be replaced by robots over the next 20 years. Few empirical studies have been made in how roboticists’ visions may differ from users/affected stakeholders’ needs and concerns with these pervasive and radical changes. The REELER project aims at aligning the roboticists’ visions of a future with robots with empirically-based knowledge of human needs and societal concerns. Based on extensive robotics/SSH-RRI collaboration, REELER will offer proactive steps towards ethical and responsible robots by suggesting radical changes in current robot design procedures. Moreover, REELER will formulate guidelines in the REELER Roadmap for distributed responsibility among roboticists, users/affected stakeholders and policy-makers by closing the current gap between these. At the core of these guidelines is the concept of collaborative learning which permeates all aspects of REELER and will guide future SSH-ICT research. The main outcome of REELER is the research-based roadmap presenting a) ethical guidelines for Human Proximity Levels, b) prescriptions for how to include the voice of new types of users and affected stakeholders through Mini-Publics and call forth roboticists’ assumptions via sociodrama and c) an agent-based simulation tool for policy-making. The high level of multidisciplinarity (8 robot designers from the LEIT-ICT batch 23, anthropologists, psychologists, economists and philosophers) of the REELER research, will assure cooperation, comprehension and acceptance of SSH-research by the robotics research community. Integrating the recommendations of the REELER Roadmap fo