RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Understanding the ubiquitin-proteasome pathway to pave the way for the new anti-cancer strategies and drugs (U2P2)'.

assistant: **Innovation**

The Ubiquitin-proteasome pathway is a very attractive target for pharmacological intervention because it is necessary for the regulated and selective degradation of intracellular proteins involved in the control of most biological processes, including proliferation, and alterations of its activity or selectivity often contribute to human pathologies, especially cancer, inflammatory and degenerative diseases. However, due to the complexity of this pathway and to the variety of its substrates, major advances towards the design of drugs capable to alter the stability and thus the level of one or a few pertinent protein(s) require a deeper understanding of the fine tuning of its activity and selectivity. This project proposes an integrative analysis of the multiple biochemical, structural, spatial and temporal parameters that determine the degradation of ubiquitous regulators of cell proliferation, and to design novel anti-cancer strategies and molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Inhibitor of DUX4-IGH to Erase Acute lymphoblastic Leukaemia', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The second most important cause of death and morbidity in Europe is cancer and B-cell acute lymphoblastic leukaemia (B-ALL) is the most common paediatric cancer and cause of cancer-related death before 20 years. In up to 7% of cases, the disease is caused by rearrangements of the genetic regulator DUX4 to the IGH locus, giving rise to the DUX4-IGH fusion. While ectopic expression of DUX4 induces cell death, DUX4-IGH drives transformation. Even though the two proteins share the same DNA binding domain (dbd), DUX4 and DUX4-IGH drive the transcription of non-overlapping target genes. Through proteomics, my lab identified a specific DUX4-IGH inhibitor, which directly binds to DUX4-IGH dbd blocking the activation of target genes. Based on this evidence, the goal of IDEAL is to test the antileukemic activity of the inhibitor in pre-clinical settings.Using cellular models, I will test the ability of the inhibitor to block transformation driven by DUX4-IGH. I expect to see a significant inhibition of DUX4-IGH driven transformation in the presence of its inhibitor, associated with reduced proliferation, clonogenic and self-renewal potential. To test the efficacy of DUX4-IGH inhibition in leukemia development, I will employ animal models (murine bone marrow transplantation assays and patient derived xenografts of DUX4-IGH B-ALL) and assess disease latency in the presence or absence of the inhibitor. I predict that the inhibitor will block or significantly delay DUX4-IGH B-ALL.Pre-clinical validation of the DUX4-IGH inhibitor will help defining effective therapeutic strategies for DUX4-IGH B-ALL patients, improving clinical outcome and lowering treatment toxicity, thus overall promoting Europe's healthcare.Through IDEAL I will expand my expertise in leukaemia research and I will a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rehabilitation Hub: The World’s first Digital Recovery Therapy solution' (ReHub) targeting Horizon 2020.

assistant: **Abstract**

Over 100M people in Europe suffer from chronic musculoskeletal disorders (MSD) such as rheumatoid arthritis, neck, lumbar and shoulder pain. However, the standard rehabilitation protocol is expensive and ineffective – our work in Phase 1 confirmed that the majority of rehabilitation programmes are not followed consistently and a staggering 80% of patients abandon their treatment prematurely, increasing likelihood of reinjure. To solve this problem, Bio-Sensing Solutions has dedicated the past 3 years to developing our DyCare® ReHub tele-rehabilitation solution that offers support for diagnosis and delivers effective, personalised therapy for MSD sufferers. With our proprietary wearable sensor and intelligent algorithms, physiotherapists will, for the first time, be able to create a rehabilitation programme based on objective measurements of a patient’s muscle strength and joint movement, whilst monitoring their progress remotely, adjusting the exercises on the fly if needed.For the patient, ReHub guides them through each custom-tailored home exercise and empowers them with real-time performance biofeedback. And, with an innovative B2B2C business model, the Physician, Physiotherapist and Patient can stay connected via an easy-to-use online platform. We have validated our first prototype in 3 leading health centres, placing our innovation at TRL 7. ReHub has shown to reduce patient recovery time by 40%, boost rehab completion to 90% and increase health centre productivity by 60%. We aim to become leaders in the 4 B€ MSD rehabilitation market in Europe. We are requesting SME Instrument Phase 2 funding to optimise ReHub core algorithms, industrialise our hardware components and validate performance in 2 large-scale clinical studies. By 2022, we expect to sell a total of 1,2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Multichip module automotive digital core for electronics control unit'.

assistant: **Concept**

- To make available MCM technologies for automotive subsystems in order to solve the integration problem common to future electronics automotive systems with cost efficiency.- To transfer the results of the programme into production on a short time-scale.- To open Known Good Die availability in a flip chip configuration.A low cost existing MCM technology, based on laminated substrate (MCM-L) has been developed for telecom and computer applications. The main content of the work will consist in adapting this technology to meet automotive harsh environment requirements. The packaging and assembly techniques will be exploited to the high volumes series.Other topics addressed in this project include reliability, testability, modelling (thermomechanical and power dissipation) and implementation of a KGD technology for automotive cost and reliability requirements. Integration of passive components and MCM compatibility with insulated Metallic Substrate (Automotive Mother Board Substrate) are critical issues which are also addressed by AUDICO. The demonstration of this approach will be achieved by realising the digital core of an Electronic Control Unit including microprocessor, associated memory and the interface circuit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Ubiquitous, Permanent and Intelligent Access to Patients' Medical Files'.

assistant: **Innovation**

The DOCMEM project targets medical doctors and aims at offering them intelligent access to their patients' medical files. The Project will develop a technology and will customise it to the needs of both ambulatory and in-hospital practitioners for the context of in-hospital and homecare.The DOCMEM platform will consist of an online service combining:- A secure online service for storing and exchanging patients' medical files in a standard way;- A secure mobile access facility enabling practitioners to access their patients' file with multimedia equipment for 2.5G and 3G mobile communication;- An Intelligent user interface enabling the practitioner to interact through the mobile multimedia equipment in a natural manner.For validation purposes, the DOCMEM solution will be implemented in 3 pilot healthcare contexts in France, Greece and Italy. For almost one year, service penetration, usability, usefulness and synergy creation will be monitored in order to assess and adjust the services.Work description:The DOCMEM project will first identify and analyse user needs and constraints. The methodology used for collecting information will rely on the techniques of Interviews, Surveys, and Focus Groups. The primary user group to be targeted by the project will include ambulatory and in-hospitals practitioners, professional associations and healthcare authorities. Then the DOCMEM platform will be specified, designed and developed.This platform supports ambulatory and in-hospital practitioners in getting access to their patients' files at the time and location they need, by combining:- Secure online Patients' Files Service: Major issues are structure of patients' files, management of security and access rights, communication facilities;- Secure mobile access: Major development axes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fully digital in-beam PET for hadron therapy' in the context of a Seventh Framework call.

assistant: **Objectives**

The accuracy of dose planning and delivery in hadron beam treatment is imperative, since millimeter errors can lead to over-dosage of critical organs or under-dosage of the tumor. Treatment plans can be reliable only if controlled with the use of in-beam positron emission tomography (ib-PET). Early experiments showed that the radiation produced by activated tissues represents a much richer and ephemeral scenario than in conventional PET imaging. Unfortunately, only a small fraction of the produced radiation can be acquired because of the high noise during particle extraction. It has been shown that modularized detectors can better sustain beam brightness, but new strategies are required in order to discriminate and recovery the useful signal. This project addresses the problem of in-spill blindness with a new concept photon discrimination technique based on fully digital acquisition. The idea is to upgrade the key sub-systems of the ib-PET system recently developed jointly by the Technical University of Madrid and the University of Pisa, being the two organizations respectively the origin and the destination of the candidate. A modified version of detector read-out modules will provide real-time photon digital characterization, while coincidence processing will be completely re-invented. The proposed photon characterization and tomographic reconstruction techniques will be mainly based on a series of results that have been co-published and co-patented in the last few years by the author of the project. This project is expected to intensify the researcher’s professional maturity as a medical imaging system engineer, giving him the opportunity to complete a competitive work started with his PhD studies. The close collaboration with the host group and their industrial part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Voluntary Organisations and Social Inclusion in the Information Society' in the context of a Fifth Framework call.

assistant: **Objectives**

The research will study the challenges of broad adoption of IST solutions, exploring how voluntary organisations can facilitate social inclusion in the information society. The study will develop a consolidated European analysis and identify potential implications for future EU policy activities on an inclusive information society, as well as identify potential implications for future IST Programme research. A key objective is stimulation of transnational networking of researchers and practitioners working on projects and programmes to encourage a socially inclusive information society.OBJECTIVESTo conduct a study aimed at understanding the role of voluntary organisations in fostering social inclusion in the information society in Europe. To identify potential implications for future policy activities on social inclusion in the information society, and to write the research report. To stimulate transnational research networking on the role of voluntary organisations in facilitating social inclusion in the information society.DESCRIPTION OF WORKThe research will address the IST Programme objectives of socio-economic analysis for the information society, focusing on the challenges relating to broad adoption of IST solutions with particular emphasis on social inclusion and policy requirements. It will explore the role of voluntary organisations in facilitating social inclusion in the information society - a socio-economic issue that cuts across multiple IST Programme areas- and develop a consolidated European analysis. The research will identify potential implications for future policy activities on an inclusive information society, particularly in the context of the eEurope initiative, stimulate transnational research networking on this issue, and identify potential impli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Paleoceanography of the Ice-proximal Southern Ocean during Past Warm Climates'.

assistant: **Innovation**

Antarctic ice sheets are destabilizing because Southern Ocean warming causes basal melt. It is unknown how these processes will develop during future climate warming, which creates an inability to project ice sheet melt and thus global sea level rise scenarios into the future. Studying past geologic episodes, during which atmospheric carbon dioxide levels (CO2) were similar to those projected for this century and beyond, is the only way to achieve mechanistic understanding of long-term ice sheet- and ocean dynamics in warm climates. Past ocean-induced ice sheet melt is not resolved because of a paucity of quantitative proxies for past ice-proximal oceanographic conditions: sea ice, upwelling of warm water and latitudinal temperature gradients. This hampers accurate projections of future ice sheet melt and sea level rise.OceaNice will provide an integral understanding of the role of oceanography in ice sheet behavior during past warm climates, as analogy to the future. I will quantify past sea ice, upwelling of warm water and latitudinal temperature gradients in three steps:1. Calibrate newly developed dinoflagellate cyst and biomarker proxies for past oceanographic conditions to glacial-interglacial oceanographic changes. This yields quantitative tools for application further back in time.2. Apply these to two past warm climate states, during which CO2 was comparable to that of the future under strong and moderate fossil fuel emission mitigation scenarios.3. Interpolate between new reconstructions using high-resolution ocean circulation modelling for circum-Antarctic quantification of past oceanographic conditions, which will be implemented into new ice sheet model simulations.The groundbreaking new insights will deliver mechanistic understanding and quantitative estima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Real-time Data-Informed Multi-scale Computational Methods for Material Design and Processing' (DIMENSION).

assistant: **Innovation**

The fundamental importance of materials to modern society is evidenced by the way new materials have revolutionized almost every aspect of our lives. Despite the many advances, dwindling resources and more stringent demands on product cost and performance demand increasingly better material designs and production processes, resulting in a heightened reliance on computational methods.In the field of computational materials engineering, the recent emergence of data science into the mainstream is causing a paradigm shift in the way models and data are used. There is a shift from traditional simulation methods which use data mainly to calibrate parameters in models, to data-driven simulation methods which seek to bypass the use of models by extracting knowledge from large data sets. This project synergistically combines aspects of both – by developing advanced computational methods that permit multi-scale material models to be informed by available measurement data.This project addresses this challenging problem through two main tasks. In the first part, we develop dimension reduction techniques for rapid multi-scale materials simulations. These methods must be capable of dealing with deterministic and stochastic microstructure parameters reflecting variations in loading, material, and morphological properties. In the second part, the reduced order models serve as an enabler for the development of computational methods for the selection of the most informative data and its assimilation into multi-scale material models. By enabling parameter estimation and model correction, this leads to increased accuracy and precision in the prediction of engineering quantities of interest.The success of the project will give rise to a novel computational framework that enables real-time m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rethinking medieval and modern sexualities through the ‘harlot saint’ Thais' under Horizon Europe.

assistant: **Concept**

This project examines the uses, abuses, and controversies of the early Christian figure of Thais, sex worker turned saint, as a transformative lens onto the complex cultural intersection of sex and religion in the Middle Ages. THAISIS aims to answer two questions: how did this severe, shocking narrative, depicting a repentant woman walled up as a recluse, function across medieval European culture as a representation of sex work, conversion, and religious solitude? And how can modern scholars and others engage more productively with such a difficult, even offensive story? My research into Thais, an understudied example of the 'harlot saint' trope which originated in the stories about the early Christian Desert Fathers, pays attention both to the medieval incarnations of her life and identity, and to how she has evolved beyond the Middle Ages. My methodology incorporates the concerns of the burgeoning field of medievalism studies, along with more traditional literary and historical methods, to create a picture of the Thais figure as it evolved and continues to evolve. This was a story calculated to provoke strong reactions in its own time, and it continues to do so in the modern day, from the cynical novel portrait by Anatole France in 1895, to the portrayal of Thais's story as a psychodrama under patriarchy in Time's Up, Jenna Soleo-Shanks's 2019 adaptation of the tenth-century play by Hrotsvit of Gandersheim.Building on foundational work carried out during two short research fellowships, THAISIS will develop and refine my ongoing research into this saint and her story towards two key goals: shaping and completing a groundbreaking monograph on Thais's role in medieval and postmedieval literature and religious culture, and developing public engagement opportunities to bri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cosmoglobe -- mapping the universe from the Milky Way to the Big Bang' (Cosmoglobe).

assistant: **Concept**

In the aftermath of the high-precision Planck and BICEP2 experiments, cosmology has undergone a critical transition. Before 2014, most breakthroughs came as direct results of improved detector technology and increased noise sensitivity. After 2014, the main source of uncertainty will be due to astrophysical foregrounds, typically in the form of dust or synchrotron emission from the Milky Way. Indeed, this holds as true for the study of reionization and the cosmic dawn as it does for the hunt for inflationary gravitational waves. To break through this obscuring veil, it is of utmost importance to optimally exploit every piece of available information, merging the world's best observational data with the world's most advanced theoretical models. A first step toward this ultimate goal was recently published as the Planck 2015 Astrophysical Baseline Model, an effort led and conducted by myself.Here I propose to build Cosmoglobe, a comprehensive model of the radio, microwave and sub-mm sky, covering 100 MHz to 10 THz in both intensity and polarization, extending existing models by three orders of magnitude in frequency and a factor of five in angular resolution. I will leverage a recent algorithmic breakthrough in multi-resolution component separation to jointly analyze some of the world's best data sets, including C-BASS, COMAP, PASIPHAE, Planck, SPIDER, WMAP and many more. This will result in the best cosmological (CMB, SZ, CIB etc.) and astrophysical (thermal and spinning dust, synchrotron and free-free emission etc.) component maps published to date. I will then use this model to derive the world's strongest limits on, and potentially detect, inflationary gravity waves using SPIDER observations; forecast, optimize and analyze observations from the leading next-generation