RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design and creation of a yeast platform for synthesis of chiral amines by enzymatic cascades' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The development of green and robust technologies for the conversion of renewable feedstock into high-value chemicals is of great interest and challenging for the chemical industry. Although L-α-amino acids can be sustainably produced from renewable feedstock by fermentation, these amino acids are rarely being used as starting material for the chemical synthesis of high-value chiral molecules due to the lack of efficient and highly selective biocatalytic methodologies . In this project, I will design and develop a modular approach for biocatalysis in vivo enabling the conversion of natural amino acids into enantiopure alpha-chiral amines and amino-alcohols, which are important intermediates or final products for the pharmaceutical, agrochemical and fine chemical industries. Saccharomyces cerevisiae will be selected as the host organism for the biocatalytic pathway because its genome is well-known, is suitable for large scale operation, and will allow to obtain higher productivity than using bacterial strains. A library of integrative plasmids expressing the enzymes will be constructed and transformed to S. cerevisiae to obtain a yeast cell factory. The system will be optimized both on the genetic level and on the bioprocess level. The working plan will include an interdisciplinary approach involving molecular biology techniques together with metabolic engineering as well as optimization of conditions for biotransformation. Additionally, analytical chemistry methodologies for determination of yield, purity and enantiomeric excess of the products and intermediates will be required. While the state-of-the-art proves the feasibility of the project, by using our proposed approach with resting S. cerevisiae cells, we expect to make a major break-through in the field in terms o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Direct Imaging of Extrasolar Planets from LBT and VLT to E-ELT'.

assistant: **Innovation**

The direct imaging of planets around other stars has begun in earnest. The main challenge in imaging these faint companions is the large contrast between star and planet. By using a combination of adaptive optics, coronagraphs, thermal wavelength imaging and point spread function modeling, current ground based telescopes can search closer to target stars for extrasolar giant planets. The applicant proposes to continue his current exoplanet surveys using the facilities at Steward Observatory (the Large Binocular Telescope, LBT) and European facilities (the ESO Very Large Telescope, VLT) and characterize new discoveries with spectroscopy.In moving to Leiden, the applicant will use the resources to develop these exoplanet detection techniques, and start a project with a PhD student partly funded with this reintegration grant to measure the ground layer atmospheric turbulence at high telemetry rates for further analysis. By providing real world data for European Extremely Large Telescope (E-ELT) adaptive optics simulations, the performance of next generation of exoplanet instruments will be increased.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Perfluorinated Organic Compounds (PFCs) Degradation using Non-Thermal Plasma Enhanced by Boron Doped Graphene Oxide as Catalyst' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The extensive use of perfluorinated compounds (PFCs) in many industrial/commercial applications, as surfactants, emulsifiers, etc., and their high chemical stability are responsible for their ubiquitous presence in the environment. Specifically, the contamination of groundwater and drinking water supplies by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) is raising great concern as more data on PFCs toxicity in humans and wildlife is becoming available. Thus, a parallel surge in monitoring campaigns and in the search for innovative water treatment technologies for PFCs is required. Since PFCs are highly resistant to degradation by standard chemical and biological processes, advanced oxidation processes (AOPs) are being considered and, including Fenton, ozone and UV irradiation with catalysts, applied so far with limited success. Among innovative AOPs, air non-thermal plasmas (NTP), which produce several reactive species at a time, have been recently tested for the treatment of PFOA/PFOS yielding promising results. The proposed research aims to advance the state of art by developing an innovative treatment process for PFCs in which NTP is applied in combination with novel boron-doped graphene oxide (B-GO) nano photocatalysts. The catalysts synthesized and characterized by the Researcher will be tested on prepared solutions of PFOA and PFOS using various NTP reactors which are available in the beneficiary laboratory. The best catalyst-reactor combination will thus be identified; conditions and parameters will be optimized to maximize the synergy between plasma and catalyst and the efficiency of the novel hybrid plas-cat process. Real samples of contaminated groundwater will be tested to verify the process applicability to complex matrices. For excellenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Glycosylation of angiogenic factors by the hexosamine biosynthetic pathway (HBP), a nutrient sensor with a novel metabolic-signaling role in angiogenesis?”' (HBP) targeting Seventh Framework.

assistant: **Abstract**

Angiogenesis, the growth of new blood vessels, is vital for tumour malignancy. Attempts to inhibit it by blocking VEGF has had limited success in the clinic with many patients innately resistant or acquiring resistance over time. Therefore, novel anti-angiogenic therapeutic strategies are required to improve overall efficacy and reduce resistance.Novel work in the Carmeliet lab has highlighted the importance of the metabolic pathway in regulating the switch from a quiescent endothelial cell to a proliferative one. Little is known about how this angiogenic switch is regulated by metabolism and which metabolic pathways are even involved. One such pathway, the hexoasmine biosynthetic pathway (HBP) generates UDP-GlcNAc, necessary for post-translational modification of proteins via glycosylation. N-linked glycosylation can regulate growth factor receptor exposure on the surface and signaling, while O-linked glycosylation can rapidly alter the function and activity of nuclear and cytosolic proteins, alike phosphorylation.Despite the important roles these modifications have, minimal research has been done into the role of glycosylation in angiogenesis. The proposal of this project is to investigate whether the HBP regulates angiogenesis via a specific “glycosylation switch”. In particular, using multi-disciplinary gene-discovery, pharmacological and genetic approaches in various animal models (zebrafish; mouse), I propose to investigate whether changes in nutrient supply regulate EC responses (quiescence versus proliferation) through selective HBP-mediated glycosylation of Flk1 or Notch and p53, and to explore the role and relevance of the HBP and key glycosylation pathways in EC quiescence / proliferation in vitro and (pathological) angiogenesis in vivo. The combination of ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploiting Nanobodies in development of new diagnostic tools and treatment methods for Trypanosomiasis' to be submitted under Seventh Framework.

assistant: **Abstract**

African trypanosomiasis is in need of new diagnostic detection tools and new treatment methods. To date the widely used card agglutination test for trypanosomiasis is not very specific as the test is based on the screening for cross-reactive host antibodies. The availability of treatment for Trypanosmiasis on the other hand is limited due to the fact that only very few drugs are registered for use, and all can cause serious side effects in treated patients or animals.  Hence, this project will focus on the development of new and innovative diagnosis and treatment tools, using the nanobody technology that has been developed by the coordinating partner of this network. Nanobodies are small single domain antibody fragments that have unique properties that include their capacity to recognize particular epitopes (not recognized by conventional antibodies) and their improved stability.  In addition, they can be used as molecular target- or transport devices of other biological active components. As such they are excellent tools to support this project.  Despite the fact that the coordinating laboratory has been a pioneer in differential molecular characterization of African trypanosomes and were involved in the initial release of diagnostic PCR methods that have now been adopted by many other research groups, this project will deliberately adopt a different approach. Indeed, in comparison to nanobody technology, PCR based diagnostics are much more costly and require an infrastructure that is hard to sustain over prolonged periods of time in African ‘field situations’. The simplicity of the nanobody technology on the other hand makes it an excellent topic for knowledge transfer. Despite it’s high-technology approach, the technique it will be relatively easy to be adopted by la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Pottery Innovation and Transmission in East Asia: bridging expertise across continents'.

assistant: **Innovation**

Although pottery is one of humanity’s most important and enduring innovations, understanding exactly how and why pottery first appeared, as well as how, when and where the innovation subsequently spread, remains a central problem in archaeological research. It is also unclear why pottery was innovated at this particular juncture and in East Asia, much earlier than other parts of the world. In 2013, Craig (scientist in charge) and colleagues succeeded in extracting interpretable amounts of alkanoic acids from 15,000 year old pottery from Japan. Demonstration that lipids survive in pottery of this age provides the first opportunity to directly investigate the origins and development of pottery in East Asia by reconstructing pottery use and function. Knowing how early pottery was used provides the strongest indication of why it was used, and this is the rationale for the proposed research. BRIDGE aims to unite the host’s recent state-of-the-art expertise in organic residue analysis, with expertise of East Asian prehistoric archaeology, already acquired by the incoming fellow enhancing the European host’s chances of making a significant contribution to our understanding of the origins of pottery. The overarching aims of the proposal are to examine the use and role of pottery a) as it gradually emerged in the Japanese archipelago across a broad range of environmental settings during the final Pleistocene (15,500-11,000 BP) and b) became ‘thoroughly embedded’ in hunter-gatherer communities of the early Holocene (11,000-9, 000 BP). This will provide the first insight into why pottery was innovated and so widely adopted. In the final part of the project we will expand the geographical scope of the project to other regions of East Asia including China, Korea and Russia by conduc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mediatized Discourses on Europeanization and Their Representations in Public Perceptions' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The media framing of politics significantly shapes the features of political modernity. This discursive mediatization signifies a cultural shift in modern politics and is often driven by political preferences, as well as economic policies that underline media action. In such conditions, news coverage often tends towards a more cynical representation of politics, and the public becomes more alienated from political processes and the media. Scholars term this the “spiral of cynicism,” or, in the context of EU news, a “spiral of Euroscepticism” (Galpin & Trenz, 2016, 2). The latter is reflected in the ongoing shift from “permissive consensus” to “constraining dissensus” (Hooghe and Marks, 2008) in public support of European integration. Media framing of the European project thus plays a crucial role in constructing citizens’ perceptions of the EU and European identity and attitudes towards EU enlargement.The MEDIATIZED EU project aims to study how the media discourses are constructed to foster or hamper the European project and how they resonate among the public by focusing on the elite-media-public triangle. We believe it is crucial to reveal the specifics of such mediatization of political discourses on Europeanization across Europe, namely, the so-called Old and New European and EaP countries. We will take a comprehensive mixed-methods approach with qualitative, quantitative and deliberative research components. We will integrate desk research to review the transformations of media discourses since the start of the 21st century, content analysis and critical discourse analysis of the current media discourses, in-depth interviews with political and media elites, nation-wide representative surveys of the population, and finally, deliberative discussions with relevant publ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Correlation between quality of life, sports/recreation and education/employment in spinal cord injured people' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The purpose of this study is to examine the correlation between quality of life in spinal cord injured people, sports/recreational activities and education/employment status by level of injury, functional independence and socio-economic circumstances.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative Food Product Development Cycle: Frame for Stepping Up Research Excellence of FINS - FOODstars' (FOODstars) targeting Horizon 2020.

assistant: **Abstract**

This proposal is related to the work programme topic Twinning, H2020-TWINN-2015. The specific challenge of the will be achieved by significant strengthening of the research capacities of the Institute for Food Technology, Serbia (FINS) in the area of FOOD TECHNOLOGY in close collaboration with internationally-leading research institutions: Teagasc - Agriculture and Food Development Authority, Ireland (TEAGASC) and University of Bologna, Italy (UNIBO). Transfer of knowledge will be achieved through short-term trainings, schools, thematic workshops, study visits, joint publications and various outreach activities and will consequently allow FINS to carry out efficient and high quality research that will be transferable to industry. S&T capacity of the linked institutions will be enhanced, new ideas and scientific challenges offered and further activities and joint applications for internationally funded projects enabled. The project partners are chosen on the basis of previous cooperation and reciprocal knowledge of respective expertise. The Work Plan summarized as “The Innovative Food Product Development Cycle” consists of six Work Packages, WPs. WP 1, WP 2 and WP 3 are designed to strengthen the scientific excellence and innovation capacity of FINS . The creation of preconditions for the implementation of innovative food solutions in industrial scales and the commercialization of research results will be performed by activities within WP 4. WP 5 is devoted to dissemination and networking activities and exploitation of results in order to establish a communication bridges between research community and industry and strategic and durable cooperation with partner institutions. WP 6 is designed to enable smooth project execution according to standard procedures and a straig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'User Centred Computer Animation Techniques for Next Generation Digital Creation and Modelling' (ANINEX), addressing dissemination and exploitation.

assistant: **Impact**

The “AniNex” Consortium consisting of five partners (two EU Beneficiaries and three Partners in China), who are world leading influential centres of excellence in both the academic world and industry.The “AniNex” is designed to anticipate and lead the development of next generation techniques related to computer animation and its applications, via integrating knowledge and talents of people from top institutions across the world who have been at the forefront of the relevant fields for many years. This will be achieved by research collaboration at various levels and scheduled staff exchange among five partners of the consortium through the well aligned work packages. To answer the current challenge in digital creation and modelling, the emphasis is on two main cores: “dynamics and interaction of virtual objects - DynO” and “virtual character modelling, and animation - XMAn”, but other elements like rendering and geometric modelling are naturally incorporated as well. The focus on “User Centred Experience” will distinguish the proposed practice from pure theoretical research, providing practical guidance and standard for techniques to best suit the users’ need and developing easy-to-use tools/software.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative and Practical Breeding Tools for Improved Dairy Products from More Robust Dairy Cattle', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of ROBUSTMILK is to develop new practical technologies to allow breeders to re-focus their selection to include milk quality and dairy cow robustness and to evaluate the consequences of selection for these traits taking cognisance of various milk production systems. Six research organisations, all with a strong network in the animal breeding industry, have agreed to share knowledge and resources to develop a strong research program to achieve this objective. Each partner has its own specialised expertise (phenotypic recording, statistics, genomics) and unique data available, in the form of milk quality and dairy cattle robustness. The overall objective is achieved by five integrated workpackages, each having their own objective: 1) Creation of a common data-base that includes unique and scarcely recorded phenotypic measurements for traits underlying robustness and milk quality, together with productivity records and fertility; 2) to develop phenotypic measurement tools for robustness (energy balance) and milk quality (lactoferrin and fatty acid composition) using mid-infrared spectrometry; 3) to develop statistical tools to select for robustness and milk quality (udder health and SCC) taking into account complex biological backgrounds; 4) to develop genomic tools for selection for productivity, robustness (fertility, energy balance and udder health) and milk quality traits (lactoferrin and fatty acid composition); and 5) integrating and disseminating knowledge on the consequences of selection practises on robustness and milk quality. ROBUSTMILK has the potential to enhance the competitiveness of European agriculture through the production of higher quality dairy products and more sustainable dairy production systems. ROBUSTMILK will contribute significantl