RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Providing Computational Insights into Cardiac Xenotransplantation' to be submitted under Horizon Europe.

assistant: **Abstract**

We are at the dawn of a new age in medicine, marked by the first pig-to-human heart transplant. Xenotransplantation has long been a dream for clinicians and now, due to rapid progress in gene editing, is becoming a reality. To overcome immediate rejection, barriers of immunity and infection have to be overcome, however, achieving long-term success requires a deep understanding of the physiological and mechanical challenges introduced by the anatomically dissimilar xenotransplants. XENOSIM aims to address these challenges by providing fundamental clinical insights into the nascent field of cardiac xenotransplantation through the development and application of novel high-resolution, higher-order, multiphysics simulation methods. Tremendous progress has been made in biomedical imaging, nonetheless, a multitude of physical phenomena relevant to xenotransplantation are not available for experimental observation. In silico studies are uniquely placed to provide insights into the haemodynamic disruption caused by replacing a human heart with an anatomically dissimilar one. XENOSIM is targeting the establishment of the first family of porcine cardiac xenotransplant models that can provide clinically significant insights into the haemodynamic compatibility of porcine donor hearts, the impact of surgical approach, and the consequence of pathologies. To provide these novel insights requires new coupled simulation approaches. Accordingly, the second goal of XENOSIM is to create a new class of monolithic finite volume fluid-electro-solid interaction methods, which can provide predictions in clinically relevant timescales through the exploitation of hybrid CPU-GPU systems. XENOSIM will establish the new field of computational cardiac xenotransplantation. Furthermore, the novel numeri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Computing Real-World Phenomena with Dynamically Changing Complex Networks' (DYNANETS) under Seventh Framework.

assistant: **Objectives**

Recent advances in experimental techniques such as detectors, sensors, and scanners have opened up new windows into physical and biological processes on many levels of detail. The complete cascade from the individual components to the fully integrated multi-science systems crosses many orders of magnitude in temporal and spatial scales. The challenge is to study not only the fundamental processes on all these separate scales, but also their mutual coupling through the scales in the overall system, and the resulting emergent properties. These complex systems display endless signatures of order, disorder, self-organization and self-annihilation. Understanding, quantifying and handling this information complexity is one of the biggest scientific challenges of our time. Amazingly nature seems to be able to process information on many spatial scales simultaneously. DynaNets will study and develop a new paradigm of computing through Dynamically Changing Complex Networks reproducing the way nature processes information. It will develop theory and methods of dynamical networks providing us with new insights into the underlying processes of nature, economy, and society. As a pilot study we will investigate the dynamics of the HIV and influenza epidemics from the molecule all the way up to the population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European lifestyles and marine ecosystems' in the context of a Sixth Framework call.

assistant: **Objectives**

Marine ecosystems posses great intrinsic value as reserves of biological diversity and are vital providers of goods and services to humanity. However, they are often disregarded during economic and social development. Europe's four sea areas; the Baltic, NE Atlantic, Mediterranean and Black Sea have each paid a heavy price for unsustainable development within their catchments and sea areas. Their ecosystems have suffered to differing degrees from eutrophication, chemical pollution, unsustainable fisheries and physical destruction of habitats.This damage is closely connected with human lifestyles throughout the continent. The future integrity of marine systems depends on our approach to European development in the coming decades. Bringing marine ecosystems into policies for sustainable development requires better information on the causal connections between human pressures and the changing state of the systems. This is particularly important at a time when the European Community is expanding, re-examining its agricultural and chemical policies, implementing a new fisheries policy and exploring new ways to protect marine systems.ELME will enhance understanding of causality, forecast the impacts of divergent development scenarios and inform evolving Community policies. Current interdisciplinary knowledge linking lifestyles with their marine environmental consequences is widely dispersed. ELME brings together a necessarily large consortium, covering all relevant disciplines and regions. It integrates existing knowledge of environmental state changes, sectoral pressures and social and economic drivers using a common conceptual model.It will select contextual indicators for each causal level and model the relationships between them. These models will be applied to plausible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Datpe' (DATPE).

assistant: **Innovation**

The Conference series Dynamic Aspects of Taxation and Public Expenditure consists of three meetings and intends to address the long- and short run consequences of tax and public- expenditure policy, integrating the latest research findings and methodology. The meetings will bring together European experts (based in Europe as well as in the US) and young scholars. The conferences will enhance research of the dynamic aspect of public economics, which is underrepresented in comparison to the static literature.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cell size as driver of stem cell aging and cancer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The failure to regenerate tissue underlies a challenging health issue in elderly. A main contributor to this decline is the loss of stem cell function during aging. Despite the essential role of stem cells, it is unclear how they fail to maintain their functions during aging and disease. I discovered a new aspect of stem cell aging in vivo: cellular enlargement. With age, stem cells increase in size leading to their functional decline. However, it is unclear how size impacts stem cell fitness. Moreover, the physiological importance of this process remains unsolved.My team at the University of Helsinki will address these questions by: (1) identifying pathways that promote stem cell dysfunction during enlargement, (2) assessing the effects of size reduction on stem cell rejuvenation, and (3) illuminating the effects of stem cell size on cancer.Supported by preliminary data, I hypothesize that cell size is a driver of stem cell aging and cancer. Using hematopoietic stem cells (HSCs) of mouse models, I will identify the molecular mechanisms impairing fitness of large HSCs. I will also perform a screen to identify pathways that modulate the size of HSCs to test for rejuvenation. These will allow me to establish how HSC size affects other cellular aging pathways, organismal health and whether this relationship is causal or correlative. I hypothesize that cellular size impacts HSCs to transform into cancerous cells. To test this, I will use differently sized, oncogenic HSCs from mice and humans to test their potential to facilitate leukemia in vivo and to investigate the underlying mechanisms of this process.The novel concepts outlined here have exceptional potential for scientific impact as they add a new paradigm to stem cell aging, provide transformative treatment perspecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Towards modulator therapy for ADA2 deficiency'.

assistant: **Objectives**

Human ADA2 deficiency is a rare inborn error of immunity caused by pathogenic variants in ADA2. The disease has a wide array of presentations ranging from vasculitis of the skin to the central nervous system (with strokes), fevers and immunodeficiency to cytopenia and bone marrow failure. Mortality is 10%, and occurs mostly in childhood. TNF inhibitor treatment is efficient for treating the vasculitis, but the bone marrow failure is refractory to treatment and requires hematopoietic stem cell transplantation (HSCT). In the context of DADA2, HSCT is complicated by graft failure in a high percentage of patients. Therefore, the treatment of cytopenia in DADA2 represents an urgent medical need. This project is built on the discovery, made during the course of the ERC St Grant MORE2DADA2,  that it is possible to restore ADA2 expression in missense mutant cells by drug intervention in vitro, providing a first layer of evidence for the possibility to use modulator therapy in ADA2 deficiency. Therefore in this project, we wish to identify additional modulators for ADA2. Our goal is to identify drugs that are able to restore in part or completely the ADA2 expression and function as well as the transcriptomic and metabolomic signature of ADA2 mutant cells. The ultimate goal is to take these modulators to the DADA2 patients.


**Keywords:** DADA2, modulator therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microplastic pollution in freshwater sediments: effects at the hydrology, microbial biofilm and thus water quality under global change threats' to be submitted under Horizon Europe.

assistant: **Abstract**

We live in the “plastic age”. Plastics are key for societal innovation and used on a daily basis. However, due to their ubiquity, persistence, inadequate management & improper waste disposal, they tend to accumulate in the environment. Besides, during their life cycle, they degrade into tiny polluting bits called microplastics (MP<5mm), considered a major environmental threat. Biodegradable plastics (BioMP) have become an alternative since they can be mineralized under certain temperature and moisture conditions. Fluvial sediments and their inherent microbial communities could potentially decompose BioMP due to their role as a nutrient recycling and its high enzymatic activity. However, how the degradation of BioMP will affect nutrient re-cycles in aquatic ecosystems, an essential ecological service, is still unknown. In addition, global change, especially, rising temperature, and hydrologic extreme events, mobilize plastics in freshwater systems and further degrading them into MPs. Thus, there is an urgent need to develop tools to assess, predict and mitigate their effects on freshwater ecosystems. SEDIPLASTIC seeks to explore and provide new knowledge on MP (non- and biodegradable) effects on freshwater sediments under global change conditions. Sediment columns with different grain size, with/without microbial communities, and microparticles (inert, MP, BioMP) will be used. Hydrological parameters, nutrients, dissolved organic carbon, bacterial biomass, viability, and functionality, and MP mobility and degradation will be analysed. Moreover, to better understand the key role of MP in freshwater sediments and how can affect ecosystems services, a predictive model will be developed using project experimental data. Project outcomes will impact beyond academia providing n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'International Conference of Atomic Physics' under Fifth Framework.

assistant: **Concept**

The International Conference of Atomic Physics, ICAP2000, constitutes a top-level forum for discussing frontier achievements in atom physics. Conference topics will include all recent theoretical as well as experimental approaches concerning atoms and their interactions. This conference aims to provide guidelines for future scientific development in the field and to identify possible relations with other fundamental as well as applied research fields, to promote co-operation.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00372-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Vital Mind' (VM).

assistant: **Concept**

Cognitive decline in aging people can often be accompanied by mental, physical and social hardship. Cognitive training and, in particular computerized training in executive functioning, memory and speed of processing is associated with prolonging personal autonomy in these three life domains. However, many among the elderly are computer illiterate, and cannot benefit from the growing number of computer programs designed to train cognition.  Instead, the elderly resort to television viewing, known to have adverse cognitive effects on aging . Today the elderly represent the largest proportion of the television viewing public. This project will use cognitive psychology, the television medium and advanced interactive Information Computer Technology (ICT) to enable older adults to actively and autonomously participate in mind fitness activities while sitting in front of their TV set. The research question of whether cognitive training will prove more beneficial if trained in de-contextualized, contextualized settings or in both settings will be verified using randomized, double-blind methodology. This home-based tool would be inexpensive and easy to use for healthy or handicapped individuals. The project fits in propitiously with recent developments: DTV is planned for deployment in Europe and the Digital Terrestrial Broadcasting (DVB-T), which will use MHP STB technology including the DVB-C, DVB-S and the IPTV, is planned to replace the Analog Broadcasting by 2010. New advancement in USB Memory Flash Cards (Disk on Key") and the MHP STB having a USB port will provide new alternatives for delivery of content to the TV.  Vital Mind also proposes innovative developments in the detection of hand movements, non-speech (vocal) as well as in the use of the iDTV remote control so a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An innovative family of antibiotics to fight multi-resistant bacteria' (ENTRAP).

assistant: **Innovation**

Antibiotic resistant bacteria are rapidly emerging worldwide. This antibiotic resistance crisis is notably connected to the massive misuse of antibiotics and the lack of novel and efficient compounds. With countless structures and properties, natural products including ribosomally synthesized and post-translationally modified peptides (RiPP) are a promising source of antibiotics . However, their development as effective antibiotics faces many challenges related notably to their synthesis, stability and bioavailability. In the frame of this project, we aim to engineer a novel class of RiPPs in order to develop innovative antibiotics.


**Keywords:** Natural product, antibiotic, peptide, multi-resistant bacteria, Staphylococcus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biochemical and molecular genetic characterization of novel protective antigens against group B Streptococcus' in the context of a Sixth Framework call.

assistant: **Objectives**

This application proposes a postdoctoral training period in genomic approaches to development of vaccines against bacterial pathogens. Until recently, vaccine research followed a series of bottom up steps beginning from identification of virulence factors through serological or genetic approaches. With the availability of complete genome sequence of bacterial pathogens, this process has been reversed.From the genome sequence, every protein produced by the bacteria can be identified. High throughput cloning and expression of the predicited proteins leads to the production of several hundred recombinant antigens which can be tested in appropriate models of immunogenicity. This approach has been taken at the host institute to identify several novel candidates for a vaccine against Group B Streptococcus (GBS). In collaboration with TIGR, the sequence of the genome of a serotype V strain of GBS was determined. Using the Reverse Vaccinology" approach several novel protective antigens against GBS have been identified.A key protective antigen, antigen 80, identified in the genomic screen, is a surface exposed protein containing the LPXTG motif involved in cell wall attachment and shares some similarity with proteins involved in extracellular matrix adhesion. The overall objective of this proposal is to characterize structure, function and regulation of expression of antigen 80 to better understand its role in GBS physiology and/or pathophysiology.Biochemical, molecular genetic and bioinformatic approaches will be taken to identify structural characteristics of the protein, to identify functional domains within the protein and to define protective epitopes exposed on the surface of the bacteria. Proteomic and microarray technology will be used to study the regulation of expressi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cluster Action For Ecosystem Innovation Network' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

CAFEIN aims at facilitating the design and subsequent adoption by national innovation funding agencies (members of the Innovation Funding Advisory Board) of an inclusive and cross border joint action plan to support the green industrial transition of their SMEs. The action plan will participate to make Europe climate neutral by 2050 with improved circular economy, resource efficiency and resilience, building European industrial value chains. The project uses a bottom-up approach, where national cluster associations act as facilitators and innovation ecosystem experts for national funding agencies. Having associations of clusters as partners will allow to efficiently engage and connect all stakeholders of the quadruple helix  (public authorities, start-ups, SMEs, large companies, investors, research and innovation actors, academia, incubators and business servicCAFEIN aims at facilitating the design and subsequent adoption by national innovation funding agencies (members of the project’s Innovation Funding Advisory Board) of an inclusive joint action plan to support the green industrial transition of their SMEs. This joint action plan will participate to make Europe climate neutral by 2050 with improved circular economy, resource efficiency and resilience, building European industrial value chains. The project uses a bottom-up approach, where association of clusters act as facilitators and ecosystems experts for national funding agencies. Having associations of clusters as partners will allow to efficiently engage and connect all the quadruple helix’s stakeholders (public authorities, start-ups, SMEs, large companies, investors, research and innovation actors, academia, incubators and business service providers). Citizens will also be addressed, making them aware on the