RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evaluating Dermal Metabolism and Uptake as Pathways of Human Exposure to Per- and PolyFluoroAlkyl Substances (PFAS) in Cosmetics (FluoroCosm)' (PFAS).

assistant: **Innovation**

FluoroCosm is a multidisciplinary project that combines advanced environmental analytical chemistry with innovative 3D human tissue culture techniques to study the dermal absorption of per- and polyfluoroalkyl substances (PFAS) from Cosmetic products. Recent studies detected PFAS compounds in various cosmetic products on the European market at high levels (up to 470 μg/g). The main hypothesis that FluoroCosm tests is that PFAS can be metabolized and absorbed through human skin, suggesting frequent contact with PFAS-containing cosmetics can lead to significant body burdens and thus adverse health effects. While dermal contact with consumer products has been highlighted as a major pathway of human exposure to brominated flame retardants and was correlated with their levels in serum, no information are currently available on the dermal metabolism/absorption of PFAS, which hinders accurate risk assessment of these chemicals. Therefore, FluoroCosm aims to fill this major research gap by assessing human dermal metabolism/absorption of various PFAS present in Cosmetics, through real-life exposure scenarios.This will be achieved using innovative in vitro 3D human skin equivalent cultures as alternatives to animal/human tissues. The results will be applied to develop an advanced pharmacokinetic model to evaluate the contribution of the dermal pathway to PFAS human body burdens and the potential toxic implications for such exposure.Our vision is that improved understanding of various aspects of human dermal exposure to PFAS will provide for more accurate risk assessment studies. This will benefit public health and regulators by providing the necessary knowledge base to inform policies on correct measurements to limit human exposure to PFAS. FluoroCosm will also benefit scientists
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Enzymatic approach to Chiral multifunctional materials for advanced applications'.

assistant: **Objectives**

This research proposal brings together the skills of Dr Chris Duxbury, a young, talented polymer chemist, with the industrial resources, experience and knowledge of DSM. The goal of this research is the development of new enzyme based techniques for the preparation of novel functional branched materials consisting of chiral polymers enzymatically grafted from multifunctional (dendritic) initiators. Chiral polymers are extremely difficult to make by conventional chemistry but can exhibit interesting properties such as customisable degradation profiles. These materials will not only be of enormous interest from a scientific point of view, but will also open new avenues in high added value applications such as biomedical devices due to their unique properties.The synthetic route utilises a novel biotechnological chemoenzymatic process recently developed at DSM, Dynamic Kinetic Resolution Polymerisation (DKRP), in conjunction with enzymatic grafting, another new research field. DSM is unique in the world in having the combination of expertise required to carry out this groundbreaking research. The research detailed here is highly multidisciplinary and as such will provide Dr Chris Duxbury with new skills in a variety of fields. In addition, he will also benefit from the experience of working within state of the art laboratories within an industrial environment. DSM will also be able to provide additional training at the highest levels in related, non-scientific areas such as intellectual property and patents. All of this training will be invaluable for his future career.The combination of this state of the art technology in an outstanding industrial research environment at DSM with the strong portfolio of skills from Dr. Chris Duxbury will deliver significant breakthroughs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Building Information Modelling based tools & technologies for fast and efficient RENovation of residential buildings' (BIM4REN).

assistant: **Innovation**

If BIM is key to address the construction sector growing technical complexity, to overcome construction processes fragmentation and communication problems between stakeholders, to reduce on-site time and improve quality and affordability, its uptake for the renovation of the EU existing building stock is yet to come and already late. To face this BIM4REN starts from 3 workflows adapted to the construction sector segmentation (90% of companies are SMEs) presenting particular technical and organisational requirements and has adapted the project and consortium to provide adequate and innovative processes, methodologies, software and hardware tools & BIM developments for each one of them, backboned by state of the art BIM technologies like worldwide used BIM Server (open-source) and BIM Bots by TNO among many others. BIM4REN gathers together top European RTOs active in the Built Environment domain (Nobatek, CSTB, Tecnalia, TNO, Fraunhofer ISE) alongside key industrial actors (EDF, CMB Carpi & ATI Project (leading BIM implementers in the EU market) with 2 Universities (RWTH & Vilnius Gedimas) and up to 11 SMEs: R&D performing (R2M, Ekodenge), SME contractors (Kursaal) and technology providers (IES, EnerBIM, WiseBIM, VRM, AEC3, etc.) with the European Builders Confederation, the Green Building Council Italy and a large French Social Housing Organisation (Logirep) representing the whole residential renovation value chain. B4R digital ecosystem will be accessible via a web based One Stop Access Platform, where depending on each user profile and needs, orientation, best practice examples from a dedicated database and links to the different tools and services (from Top-grade to Entry-level) will be provided on differentiated access schemes underpinned by different business models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Heterogeneous Integration for Connectivity and Sustainability' (HICONNECTS) under Horizon Europe.

assistant: **Objectives**

The  challenges and major HiCONNECTS objectives are to transform the centralized cloud platform to decentralized platforms which include edge cloud computing in a sustainable, energy-efficient way. This will bring cloud services including Artificial Intelligence (AI) closer to the IOT end-users, which enables them to really use the COT and IOT efficiently. The technologies underpinning this revolutionary step include the development of high-performance computing, storage infrastructure, network interfaces and connecting media , and the analysis of IOT sensors and big data in real-time. This major step forward will enable, for example, the mobile clients (during the 5G deployment phase and 6G exploration) to move among different places with minimum cost, short response time and with stable connection between cloud nodes and mobile devices.The main underlying technology to be developed by the HiCONNECTS consortium, comprising large industrial players, universities and RTO’s, and many SMEs, can be summarized under the title: ’heterogenous integration’ (HI) which is needed to meet the computing power, bandwidth, latency and sensing requirements for the next generation cloud and edge computing and applications. The HI revolution brings the electronic components and systems (ECS) into a new domain, which combines  traditional silicon wafers integrated circuit (IC), InP based high speed electronics , and Si and InP photonics devices and interconnect.The HiCONNECTS ambition is to demonstrate, through HI development, a leap in  computing and networking reliability and performances across the full vertical and horizontal ECS value chain (i.e. essential capabilities and key applications) in a sustainable way. In addition, HiCONNECTS will focus on the development of next generation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MOveable Bearings Innovation Launch in enlarged Europe' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Bridge weight and traffic loads as well as braking and wind forces generate a number of different forces that must be transmitted to the ground through bridge piers and abutments This is the task of bridge bearings designed manufactured and installed to permit movements and torsional effects caused by traffic temperature variations pre stress shrinkage and creep Bridge bearings are therefore critical components of a bridge structure and demand high quality standards An ongoing increase of traffic volume higher cruising speeds and more flexible structures result in a redefinition of requirements for bearing systems.Furthermore the ambitions of bridge engineers to exceed not even finalised constructions in its dimensions and technical performances are transferring their challenge also to bridge bearing manufactures The lack in reasonable technologies to meet these extreme product specifications mainly result in expensive custom made products with reduced lifetime performance To encounter the current situation with sustainable structure life cycle costs LCC the bridge bearing manufacturers agree on the potential of reconsidered sliding bearings Therefore the consortium is ready to develop a new generation of sliding bearings with higher performance advanced materials better constructability and maintainability as well as significantly extended lifetimeThe corporation of the participating manufacturers has to be seen as alliance against competition from the US and Asia Especially Eastern Europe where the establishment of a sustainable infrastructure has priority for the whole European Union was recognized as potential market A high number of eastern end user which are confronted with accumulated needs for sustainable products support the project with valuable requests and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SWAN: Blitzscaling  the early detection  of skin cancer' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Swan is a breakthrough solution to the enduring problem of detecting skin cancer early. For the first time, Swan enables *full-body* scanning at *dermoscopic* resolution and in less than *3* minutes to the benefit of *all* stakeholders: patients, physicians, hospitals and payers.The solution captures key data that dermatologists acutely need for early diagnosis and brings breakthrough AI triage assistance to flag concerning lesions. Significant medical time is saved in the process and for patients, the impact is faster access to treatment when needed, fewer unnecessary biopsies and peace of mind. The solution combines hardware and software and is at the crossroads of cutting-edge, patented technologies in real-time 3D human avatar generation, advanced robotic control, image processing and AI classification of lesions. Our ambition is to make best-in-class skin cancer screening accessible to everyone, everywhere and finally help dermatology make a quantum leap forward.


**Keywords:** Deep learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Structural interaction between antibodies against human cytomegalovirus and their epitopes and its implication for antibody biological activity'.

assistant: **Concept**

The primary objective of this project is to define major structural parameters involved in promoting antibody-mediated neutralization of human cytomegalovirus (CMV) and to design human antibodies with perfected functions in this respect. Since this virus is a major health concern in immunocompromised individuals, such as neonatally infected children, transplantation patients and AIDS patients, such advances have important implication for the diagnosis and treatment of such disease. The project will furthermore yield information on how an in-vitro molecular evolution of an antibody specificity should proceed, using rational design and in-vitro selection, to provide an optimally efficient antibody, which might serve as a lead candidate in future passive immunotherapy studies. The ultimate goal will be achieved by combining, in a multi-disciplinary (immunotechnology, virology, medical virology and structural biology) approach, recently developed (i)technologies to obtain antibodies/antibody fragments by phage display selection (ii) methodology designed to study the molecular interactions in three dimensions between the antigen and selected antibodies (iii) methodology focusing on the biological function (virus neutralization) of the developed antibodies. More specifically, we will create antibody gene libraries, for use in phage display of antibodies and select these in-vitro on a variety of recombinant CMV antigens exposing glycoprotein B-related epitopes. This antigen has been chosen since it is known to be the most important target for CMV-neutralizing antibodies. Antibody/antigen interactions will subsequently be characterized by: (i)their ultra fine specificity at the molecular level by reactivity pattern analysis against e.g. mutated antigens and defined clinical iso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel biobased formulations for CIRCULAR Construction materials' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

CIRCULAR-C is a demand-driven research and innovation action aiming to transform the biobased chemical sector for construction applications by developing a new generation of circular, sustainable, and biobased adhesives, coatings, and functionalised fibres at TRL 5. These new formulations for wood panel construction (used in flooring, furniture, and insulation) featuring reversible chemical bonds and Digital Product Passports enhance recycling and reduce environmental impact.Thus, CIRCULAR-C will validate and optimise a process using mixed sustainable biomass residues as feedstock to produce high-strength functionalised cellulosic materials and circular adhesives and coatings with high bio-based content, fire retardancy and reversibility. Industrial partners will test these formulations in construction panels and validate them against industry requirements. In addition, the novel disassembly, recycling, and remanufacturing of the panels will be validated, and comprehensive digital product passports (DPPs) prepared to track the lifecycle and sustainability metrics of our products. The safety, circularity, and sustainability of processes and products will be assessed during all development stages, and we will ensure that the project outcomes are widely disseminated, and their economic feasibility validated. Through these efforts, CIRCULAR-C will increase the capacity of biobased sectors by maximizing residue valorisation and material recycling, as well as minimizing environmental and climate impact. Our long-term impact by 2038, calls to operate a fully scaled CIRCULAR-C plant with an annual output of 10.8 kt of adhesives, 12 kt of coatings, 50 kt of functionalised fibres and 15.3 kt non-PU foams, which could be potentially used in 75,000 residencies. This venture is expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Large-Array Capillary DNA sequencing'.

assistant: **Objectives**

This project is based on the observation that the electrophoresis step in sequencing is a major bottleneck and a considerable financial burden of the genome biomedical project. It is aimed at constructing a prototype capillary array sequencer with significantly increased output and decreased operation cost, as compared with slab-gel sequencers. Capillary electrophoresis combines the following advantages as compared with slab-gels : - Capability of sustaining higher field strengths, leading to shorter separation times - Easty automation of separation matrix replacement and sample loading - Miniaturization, allowing a larger number of samples to be studied. The project focuses on low operation cost, high automation and robustness for routine operation. It will include in particular the evaluation and optional integration in the prototype of the following innovative approaches:  - The synthesis of new acrylamido monomers, yielding sieving matrices with longer lifetime and better resistance to hydrolysis - A new family of sieving matrices based on amphiphilic polymer solutions that can be switched from liquid-like behaviour (for automated replacement of used sieving medium) to gel-like behaviour (for good separation properties) - The development and evaluation of new reporter chemistry schemes yielding a better signal/noise ratio, in particular energy-transfer dyes and lanthanide complexes - The use of pulsed-field capillary electrophoresis to increase the size range separable - A new technology for mass production of very low cost capillary arrays - An original detection scheme based on imaging techniques. The project is a continuation in part of project n BMH4-CT96-1158, Capillary Array DNA Sequencing, called CADS I in the following for the sake of terseness. This project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of Innovative Tools for OPtimal management of Recirculating Aquaculture Systems' in the context of a Horizon Europe call.

assistant: **Objectives**

Aquaculture is the world’s fastest-growing agri-tech sector. To support that growth, the industry needs to find innovative solutions to challenges, such as sustainability, disease, lack of space for expansion, and freshwater availability. Recirculating aquaculture systems (RAS) have been the answer to those problems; these land-based fish farming systems are designed to control culture conditions for intensive farming, while increasing biosecurity levels, minimizing water consumption, and managing waste streams. However, their water monitoring systems lack real-time sensors to quantify the highly toxic compounds ammonia, nitrite, and nitrate, which can accumulate in closed systems and cause the sudden death of a full production cycle.Nitrogen Sensing Solutions proposes a game-changing solution, using an innovative biosensing technology that is mastered by this science-driven startup. The minimum viable product is a portable nitrite biosensor - the NO2Aqua – that can be easily used onsite a deliver accurate results in real-time. Our second product (NOxAqua) can monitor the three N-nutrients at the same time, whereas our third product (NOxAquaPlus) will offer automation in a customized analyzer equipped with a complete sensors package, a data transmission system, and protocols for emergency response, thus reducing risks of heavy mortality and taking the RAS-based industry to Aquaculture 4.0.The company was founded by its CEO, a female researcher who moved recently to the entrepreneurship space and is willing to take the deep technology developed in her research group to the marketplace. However, the team lacks experience in business development and management and is looking for mentorship and coaching. In addition, we are seeking support to perform customer (re)discovery,