RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Highly Efficient Adaptive Multi-processor Framework' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Writing parallel programs has traditionally been considered a difficult task, even when parallelism is taken into account from the beginning. Moreover there is an urgent need to parallelize the massive amounts of legacy sequential code so as to increase its performance on processors and systems that refocus from single-thread acceleration to increasing the overall throughput. At the same time, memory (in particular cache) performance is essential to achieve the full gain from a parallelized application. However, while processor architecture tends to be relatively standard across applications within a domain, huge performance and power improvements can be achieved by tailoring the cache architecture to the application at hand, and not just to an entire domain.<br/>The HEAP project faces these challenges directly, by developing:1.\tAn innovative toolset that helps software developers profile and parallelize existing sequential implementations by exploiting top-level pipeline-style parallelism.2.\tA highly configurable cache architecture that can be tailored to an application by using the same profiling data as those that were used for parallelization, in order to fully exploit the available computing power.<br/>In particular, the HEAP project will provide1.\ta novel SMP multicore platform supporting a group of  novel cache coherence protocols; each application will be profiled so as to select and tune the most appropriate cache coherency mechanism.2.\tan innovative toolflow that complements this architecture; this tool will ease and/or automate the parallelisation of sequential C-code  based on an analysis of the dataflow while it will provide configuration and tuning data (e.g. in terms of which variables are local, and which are mostly written or mostly read by a thread
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation into Practice to Achieve Targets for Energy Efficiency' (EPATEE).

assistant: **Concept**

Directives on energy efficiency such as the EED or the EPBD trigger a great variety of policies throughout EU Member States. The effort put into developing and implementing these policies is well documented in existing NEEAPs. Soon, emphasis will be put on finding out how effective they were to create new policies that allow meeting current and future energy savings targets. Unfortunately, several barriers limit policy evaluation. This results in a lack of quantitative data, and impedes evidence-based analysis required to distinguish effective from ineffective policies. EPATEE aims at tackling this problem by raising the capacity of policymakers and implementers to assist Members States to fulfil their obligation under energy related Directives. The project will provide them both with tools and with practical knowledge to make effective impact evaluation an integral part of the policy cycle. EPATEE makes use of existing evaluation experiences in a range of instruments, such as energy efficiency obligation schemes, regulations, financial incentives and voluntary agreements. Lessons learnt from other EU initiatives and good practices in how to successfully evaluate the impact and cost-effectiveness of such energy efficiency policies will provide the basis for the development of guidelines and good practice evaluation tools. A set of 20 to 30 tools enabling state-of-the-art evaluation will be developed and integrated into a smart online toolbox, which interactively assists users in picking the most relevant tool for their specific need. This guidance material provides the basis for the most important aspect of EPATEE: target-oriented experience sharing and capacity building. Findings will be discussed together with policymakers through peer-learning workshops, webinars, di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Targeting the (pre)metastatic lympho-vascular niche: molecular mechanisms and therapeutic implications in  melanoma' (DLL4-LVN).

assistant: **Innovation**

Tumor metastasis is responsible for >90% of cancer deaths. A tumor type where the mechanisms driving this process are especially unclear is melanoma, the only cancer where apparently thin lesions (2 mm depth) have a high potential for metastatic dissemination. As a PhD student in P. Agostinis lab (KUL, Belgium) I identified a new strategy using the lysosomotropic agent chloroquine (CQ) to blunt melanoma metastasis, by normalizing the angiogenic vasculature via increased blood endothelial cell (BEC) NOTCH signaling. The complete abolishment of metastasis by CQ urged me to study whether another route of metastasis; the lymphatic system and the sentinel lymph nodes (SLN); was also affected. The importance of this route of metastasis is supported by recent evidence showing that even before the arrival of the tumor cells, the lymph endothelial cells (LEC) and immune cells in the SLN undergo dynamic changes that actively facilitate tumor cell recruitment, metastatic outgrowth and immune tolerance. This phenomenon is referred to as the ‘lymphovascular (pre)metastatic niche’.  Pending questions are how the cancer cells, LEC and immune cells crosstalk and how to target them pharmacologically.  My preliminary data, obtained during a short term EMBO Fellowship in the lab of M. Soengas (CNIO, Spain) show that CQ affects lymphangiogenesis even more than angiogenesis. These effects are due to an unexpected different wiring of the NOTCH pathway in BEC versus LEC. Activated LECs express high levels of the NOTCH ligand DLL4, which is trapped and inactivated in the endosomal compartment by CQ. Genetic interference in LEC revealed that DLL4 not only regulates lymphangiogenesis, but also the production of mediators of cancer cell homing and immune tolerance. In this project I will address
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Advancing a vaccine targeting genetic amyotrophic lateral sclerosis (C9orf72 ALS) to the clinical stage'.

assistant: **Innovation**

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is triggered by protein aggregation in the brain and spinal cord motor neurons that leads to respiratory failure within 2-5 years. The best available drug extends life by ~3 months. ALS strikes about 1 in 500 people mostly for unknown reasons, but 5-10% of cases in Caucasians are caused by a mutation in the C9orf72 gene. We have shown that this mutation leads to expression of large aggregating poly-Glycine-Alanine (poly-GA), which triggers downstream pathology. We developed a poly-GA peptide vaccine that reduces aggregates and largely prevents motor deficits in a mouse model. When starting vaccination in already symptomatic mice, our vaccine reduces neuronal damage to a similar extent. Since regular lifelong vaccination is required to maintain sufficient antibody levels, GA-VAX is an attractive business case in the orphan disease space with ~2500 prevalent C9orf72 ALS cases in the US, DE, IT, FR, ES, UK. ~9000 mutation carriers at risk to develop disease within 10 years could benefit even more from our approach. A joint venture established by Intravacc and DZNE will bring together the right resources to advance this promising treatment approach towards clinical evaluation. Intravacc contributes know-how for production and clinical development of peptide/carrier conjugate vaccines, DZNE provides in depth knowledge of disease pathology as well as all necessary model systems and assays. Together we will setup GMP manufacturing for the antigen and conduct pivotal toxicology and efficacy studies in animals in accordance with regulatory requirements by EMA and FDA. This will allow us to compile a clinical trial application in C9orf72 ALS patients. In addition, we will use this data-package to raise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Transversal Multilinear Harmonic Analysis'.

assistant: **Innovation**

This proposal consists of two intimately related programmes. The aim of Programme 1 is to make major contributions to the celebrated restriction theory for the Fourier transform and combinatorial problems of Kakeya-type using emerging multilinear techniques. The aim of Programme 2 is to develop a multilinear perspective on a much broader family of curvature-related problems in harmonic analysis, including important classes of Radon-like transforms that arise naturally in the theory of dispersive partial differential equations.The specific objectives represent major challenges at the emerging frontiers of harmonic analysis with a variety of disciplines, including geometric analysis (encompassing heat-flow methods and convex geometry), affine geometry and algebraic topology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'IMAGING AND ADVANCED GUIDANCE FOR WORKFLOW OPTIMIZATION IN INTERVENTIONAL ONCOLOGY' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. Lung and liver cancers were among the top three leading causes of cancer death in 2020 with 1.8 million and 830.000 deaths, respectively.  On the other hand, soft tissue sarcomas are relatively uncommon cancers diagnosed in about 1% of all adults, but much more common in children and young adults, accounting for 7–10% of paediatric malignancies; they are an important cause of death in the 14–29 years age group.Interventional Oncology involves miniaturized instruments (biopsy needles, ablation electrodes, intravascular catheters) and minimally-invasive access, guided by imaging techniques (X-ray, ultrasound, computed tomography, magnetic resonance imaging) – to target cancer with ablative or localized drug delivery strategies. Interventional Oncology can be used as a stand-alone approach, or in combination with the other approaches (‘pillars’) to enhance treatment efficacy. While cancer survival has significantly improved over time through innovations in each individual pillar, our current understanding of cancer now leads us to an intertwining of pillars and multimodal care pathways: Interventional Oncology is uniquely suited to leverage and enhance the effects of the conventional therapy pillars, while reducing the burden on the healthcare system.IMAGIO will leverage Interventional Oncology in the clinical setting to improve the cancer survival outcomes, through minimally invasive, efficient, and affordable care. We will deliver four complete, multimodal care pathways for two of the most aggressive cancers (liver, lung) and one of the most debilitating when treated with current approaches (sarcoma):1. Multimodal interventional imaging for fast and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Manipulating the coupling in multi-ferroic thin Films' under Sixth Framework.

assistant: **Concept**

R&D and investment in electronics overwhelmingly focus on multi-functionality, which should meet the market demands for radically new components that are more compact, cheaper, and consume less power. Particular attention is being devoted to MagnetoElectric (ME) multi-ferroics exhibiting simultaneous FerroMagnetic and FerroElectric properties, both being coupled. Such materials allow reversing the magnetization by an electric field and vice-versa. ME materials can thusly provide optimum solutions to many device-design problems, with a high potential impact on important segments of the electronics market: high-density electric field controlled MRAM, HF wireless telecoms, spintronics? However the physics of ME coupling is far from being understood. This limits knowledge-based research for materials with optimised properties, and ultimately prohibits industrial use of ME thin films.The objective of the present STREP proposal MaCoMuFi is to MAnipulate the COupling in MUltiferroic thin Films" (made of single phase, multi-layers and nanocomposite materials) to ultimately accelerate the development of novel devices for the European Industry. It will set up the first systematic knowledge-based approach in the domain, involving the tight collaboration between oxide synthesis, complex oxides modelling and device design experts.The main expected outputs of the project are:(i) novel oxide thin films (5nm thick) with significant ME coupling (higher than 1V/cm.Oe) at room temperature,(ii) performance validation in new electronic devices (spin filter, magnetic memory, agile filter),(iii) understanding the relationship between process, structure and composition of the multi-ferroic oxide thin films,(iv) optimised production processes and tailoring methods,(v) new techniques for ME coup
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Calcium-dependent somatodendritic vesicular release of neurotransmitter - s - from rat cerebellar purkinje cells and its role in retrograde communication'.

assistant: **Innovation**

Research objectives and content Recent data from the host laboratory has provided tantalising evidence for the possible somatodendritic Ca2+ -dependent vesicular release of a glutamate-like transmitter substance from cerebellar Purkinje cells (PCs). This fellowship proposal is concerned with the testing of this hypothesis using two approaches. Firstly, using thin cerebellar slices, the whole-cell recording technique will enable the dialysis of neurotoxins and other poisons of vesicular release into PCs. Secondly, using laser-scanning confocal microscopy together with the styryl dye FM1-43 in either cultured Purkinje cells or organotypic cerebellar slices, the direct visualisation of any membrane (and thus vesicular) turnover will be possible. Training content (objective, benefit and expected impact) The host laboratory has extensive experience in patch-clamp recording and optical measurements from PCs. Moreover, the institute itself uniquely possesses all the technical and intellectual facilities for the learning of fluorescence imaging (in combination with patch-clamp recording) and cell culture techniques. This will enable the applicant to gain the experience necessary to fully utilize such technically demanding experimental protocols for his own, independent research upon returning to the UK. Links with industry / industrial relevance (22) None
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'VXI industrial test application for liaison with IEEE1149.1 system environments' (VITALISE).

assistant: **Innovation**

to allow for fast prototyping of new subsystem technologies for embedded applications such as the rapidly evolving PCMCIA applications, Multi-Chip-Modules (MCMs), Systems-on-Chip (mainly for telecom and multimedia applications).The Vitalise" project demonstrates the introduction of a new generation of mixed-signal test solutions and test concepts - combined with boundary scan compliant applications - in the development organisation of a leading mobile communication supplier."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ergodic theory for non-commutative groups, using probabilistic and unitary representation methods' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Study of Dynamical systems with symmetries that are described by Lie groups. Training content (objective, benefit and expected impact) Study of the relationship between certain spectral properties of the symmetry group involved and the asymptotic behaviour of the dynamical system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Software process improvement directed to errors reduction' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

ETRA's main business are complex turn-key control systems (including software, hardware, sensors, and telecoms) in the domains of traffic, transport and public services (lighting, etc.). The company's concern on quality and improvement, particularly in what concerns Software Production, makes absolutely important continuing the stepped process successfully started with ESSI 10493 MACRO project. There is a special interest in reducing maintenance and errors costs between 15 and 20% by getting a detailed definition and implementation of Test, Installation and Maintenance phases as well as of Configuration Mgmt. Requirements Mgmt. and Errors Mgmt.THE EXPERIMENTETRA's products typically have a long life cycle, of the order of five to ten years. This fact, together with their complexity, make Maintainability, Errors Management (EM), Tests, Configuration Management (CM) and Requirements Management (RM) crucial issues. Up to now, none of these issues have been satisfactorily tackled. The pilot application to be used in SPIDER as the Baseline Project (BP) to carry out the PIE will be the kernel of ETRA's Traffic Control System.The User Requirements, Analysis, Design and Coding of the BP will be revisited, and the processes and documentation standards defined in MACRO will be applied.The testing, installation and maintenance phases will be formalised and the corresponding procedures defined, so that they are implemented, in co-ordination with the user of the system, within the frame of the BP.In parallel with the above, it will be carried out the definition, and implementation of the processes of EM, RM and CM. Special attention will be put to measurement of cost effectiveness and level of errors reduction.ETRA employs 70 people, 25 of which are involved in the development unit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Developing an Innovation-Friendly Legislative Culture – the Innovation Principle at Work'.

assistant: **Innovation**

The international high-level conference will be organised during the Finnish Presidency of the European Union Council in Helsinki in December 2019.The topic of the event is “Developing an Innovation-Friendly Legislative Culture – the Innovation Principle”. Today the pace of innovation is faster than ever. The process of preparing legislation does not necessarily match the rate of technological and digital change. The Innovation Principle seeks to ensure that regulation is designed in a way that creates the best possible ecosystem for the flourishing of innovation. The Innovation Principle thus contributes to creating a more innovation-friendly regulatory framework for the EU and, when used for national legislation, can signal the willingness of EU Member States to host and nurture innovators as well as to overcome situations of market failure.The conference aims to demonstrate that regulation can be used effectively and responsibly as a tool to pave the way for market-driven activities and innovations with the aim of providing high quality services to citizens according to objectives set for policies. The conference encourages to take a perspective that since all developments cannot be predicted, flexibility and new operating models are needed (e.g. new kind of PPPs including involvement of end users). The conference has four specific objectives:• To raise awareness and build shared understanding of the possibilities and challenges of regulation in creating markets for innovations and innovative business ecosystems in the European Union • To share experiences of forerunners and experiments in different fields both at  the EU level and in the Member States • To identify key areas where regulation could be a major driver for innovation • To identify key policy questions t