RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REGULATION OF NEURONAL GENE EXPRESSION THROUGH CHROMOSOME ARCHITECTURE' in the context of a Horizon 2020 call.

assistant: **Objectives**

A remarkable feature of the brain is its ability to adapt to changing environmental conditions. Modulation of synaptic strength and neuronal circuitry underlies experience-dependent learning, and requires widespread changes in gene expression. Following neuronal depolarisation, intracellular signalling results in rapid induction of many activity-regulated genes (ARGs).  There are numerous interconnected levels of gene regulation; one critical aspect relates to the three-dimensional conformation of chromosomes within the nucleus. Looping of genes to regulatory regions and to other genes is required for transcriptional activation in other cell types, but remains largely unexplored in neurons. In this proposal, I will investigate how the genome architecture changes during neuronal depolarisation, and how this influences activity-induced transcription and neuronal plasticity. I will first map the genomic interactions of ARGs in neurons before and after depolarisation. This experimental approach will allow identification of enhancer-promoter loops and multi-gene complexes in an unbiased manner. Single-cell imaging studies will be performed to quantify the frequency of interactions across individual neurons. I will use super-resolution microscopy to simultaneously analyse multiple loci with high precision, providing unprecedented detail of gene interactions in response to neuronal activity. Finally, I will use genome editing to disrupt specific chromosomal contacts and evaluate the transcriptional induction of associated genes. I will assess whether loss of genomic contacts affects dendritic growth, a process associated with neuronal plasticity and dependent on ARG induction, to understand the biological implications of chromosome looping. The aim of this project is to discov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Study of the molecular mechanisms underlying Toxoplasma-induced early abortions in a pregnant sheep model of infection' (TOXOSHEEP).

assistant: **Concept**

Toxoplasma gondii is a major cause of abortion in humans and livestock, thereby producing a significant public health hazard and economic losses. Most of Toxoplasma’s virulence factors have been explored using mouse models; however, the murine immune response differs significantly from that of humans and farm animals. Despite Toxoplasma’s enormous economic and health implications, little is known about the factors that cause foetal mortality and vertical transmission in humans or livestock. The goal of this ambitious project is to close this gap in knowledge by studying the mechanisms involved in the early abortion during the acute phase of toxoplasmosis in a standardised animal model relevant for humans and livestock. We hypothesise that by using a pregnant sheep model, the molecular mechanisms underlying the parasite-induced inflammation associated with early abortions can be identified. To this end, we will first characterize the early infection dynamics, lesions, parasite burden and peripheral immune response in the dams. This will provide valuable information as to the initial immune response elicited by the parasite and how it reaches the placenta. Subsequently, we will investigate the local molecular mechanisms involved in the parasite-induced pathogenesis of early abortions by combining novel immunohistopathological and transcriptomic approaches in order to identify alterations of gene expression and biological pathways in the materno-foetal interface. The results derived from this proposal will significantly advance the understanding of the mechanisms of Toxoplasma early abortions and help in the design of transmission-blocking vaccines or drugs. Because Toxoplasma has been associated with women who had spontaneous abortions, it is likely that these mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Computational Design of Multimodal Tactile Feedback within Immersive Environments' (ADVHANDTURE), addressing dissemination and exploitation.

assistant: **Impact**

These last years have seen an explosion of novel tactile technologies providing various haptic sensations across all the user's body. However, while these technologies have now been made available, virtual reality systems are still struggling to convey compelling tactile sensations for 3D interaction. As of today, tactile feedback mainly fails: (1) to render multiple haptic stimuli in a spatially coherent manner, (2) to achieve temporal integration of the stimuli compatible with the interactive framerates of immersive environments and (3) to preserve user's immersion within virtual worlds.ADVHANDTURE aims at targeting all the above limitations by introducing a ground-breaking computational approach for handling multimodal tactile feedback within immersive environments. My original methodology proposes for the first time the introduction of  perceptual data at each step of the design of the computational models dedicated to immersive tactile haptics. Thanks to its innovative approach, ADVHANDTURE will address the design of: (a) physics-based models able to simulate the rendering of various tactile inputs, (b) computationally-efficient algorithms integrating multimodal tactile stimuli within immersive environments and (c) 3D interaction paradigms for combining multimodal tactile stimuli with multi-sensory information.In addition to significant advances in the design of computational haptic rendering models, ADVHANDTURE, in the long run, will considerably enrich our 3D interaction with virtual worlds by providing realistic multi-sensory feedback with multiple tactile sensations. Thanks to its multidisciplinary aspect, ADVHANDTURE will propose synergistic outcomes contributing to our understanding of the haptic perception of virtual worlds, as well as the underlying models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Efficient Cooling Systems for QUieter Surface Transport' (ECOQUEST).

assistant: **Concept**

An important subsystem in surface transportation vehicles (rail bound, automotive and heavy duty) is the cooling unit. Present European standards for interoperability of rail bound traffic require low noise levels while manufactures need to meet the vehicle performance and energy efficiency requested by the operators. The stringent EU6 emission limits expected to come into effect will increase dramatically the demand for cooling power in road vehicles without accepting a noise penalty. Manufactures need innovative methods for reducing costs of development and testing and thus further improving their competitiveness in the global market.The objectives are innovative contributions towards novel cooling units with reduced noise radiation and decreased CO2 emissions. We aim at new compact lay outs, innovative heat management strategies and low energy/noise components. Intermediate objectives concern (i) implementation of an integrated simulation platform for noise mechanisms, scattering and propagation; (ii) development of design procedures for thermally and acoustically optimal cooling units; (iii) research on innovative fan designs and new passive noise control measures and their integration into novel cooling units. Mass produced automotive units and large locomotive systems produced at small numbers are considered simultaneously - strong synergies and cross-fertilization are expected.The project is structured in five work packages. WP1 deals with the project co-ordination.  WP2 focuses on the acoustical models and their integration, WP3 takes into account realistic train and automotive environments, WP4 deals with full scale vehicle tests and WP5 concludes the projekt with an assessment. and and an exploitation plan and dissimation. Being an upstream-research oriented p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Walls and Wicked Problems: The Role of Complexity in Politics' (COMPLEXPOL) targeting Horizon Europe.

assistant: **Abstract**

Politics is about solving our world's most complex problems. Solving “wicked problems” like climate change or migration involves myriad actors, contested priorities, uncertain outcomes, and interdependent processes. In the face of such complexity, policymakers sometimes propose simple solutions. US President Donald Trump proposed building a wall to “solve” immigration. British Conservatives proposed cutting all ties with the EU in a “hard Brexit”. Both won elections on these simple narratives. Conversely, the lack of a similarly simple idea to address climate change seems to hinder global progress. Each of these events is a story of a contest between complex and simple ideas. Yet political science lacks clear theories about the nature and strategic uses of complexity, focusing mostly on text complexity measures like readability. Without a theory of idea complexity, scholars cannot explain why Trump proposed a wall, nor why the idea was popular with voters. If we understand political complexity better—if we make it explicit instead of implicit in our theories—we also understand our current moment better.COMPLEXPOL will build new theories of and evidence for the role of complexity in politics. It does so through three work packages that rely on multiple methods, including quantitative modelling, survey, experimental, and computational methods, and novel data on voters and political leaders in three countries. In WP1, I will develop new, multidimensional measures of complexity, particularly of ideas. In WP2, I will explore the social and psychological determinants of individual attitudes toward complexity. And in WP3, I will investigate the strategic use of complexity by leaders and the public's reactions. In so doing, COMPLEXPOL will provide fresh insights into why some p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional analysis of wt1 variants' under Fifth Framework.

assistant: **Concept**

Mutations in WT1 result in different developmental abnormalities, among which is Wilms' tumor. Many different isoforms of the protein have been described, with different functions for at least some of them. However, many of the studies describing these differences have been in vitro experiments using artificial (over expression) situations. In this project we will analyze the phenotypical effects of limiting the number of different isoforms a cell can express through a genetically approach. Our main focus will be on two alternative splicing events in the gene, determining the use of exon 5 and the use of three additional amino acids (KTS), since disturbance of the ratio between expression levels of these variants is a potential inactivation mechanism of WT1 in malignancies. To study the different functions of these variants in a physiological context we will generate a high-efficiency system to manipulate the Wt1 gene in mouse ES cells . We intend to use a RMCF (recombines-mediated cassette exchange) approach, in which F1p-mediated recombination is used to transfer variant Wt1 genes from a BAC to the endogenous Wt1 locus. This system will be used to generate mouse models only expressing Wt1 variants with or without exon 5 for in vivo analysis. Additionally, variants with the four possible combinations of the exon 5 and KTS splice variants will be generated for extensive in vitro analysis in a molecular, biochemical and cell biological context.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sustainable Urban Neighbourhoods - Research and Implementation Support in Europe' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SUNRISE will develop, implement, assess and facilitate learning about new, collaborative ways to address common mobility challenges at the neighbourhood level. Towards this aim, 6 cities will foster collaborative processes in specific neighbourhoods as “Neighbourhood Mobility Labs” with the explicit mandate to implement innovative solutions for and with their residents, businesses etc.SUNRISE rests on several pillars: A) Utilisation of neighbourhood-specific opportunities. B) Co-creation of solutions, i.e. through strategic civic-public alliances C) Socio-technical nature of solutions as combinations of services, social arrangements, rules, technologies or small infrastructures etc. D) New forms of synergies between bottom-up and top-down.All SUNRISE activities are structured along the following phases of the innovation chain: 1) Co-identification of mobility problems; 2) Co-planning / co-selection of solutions; 3) Co-implementation of solutions; 4) Co-evaluation; 5) Co-learning and uptake.The SUNRISE action neighbourhoods will use a blend of proven state-of-the-art online and face-to-face participation techniques and will establish longer-term collaborative forums. These will systematically involve citizens, businesses, NGOs, local authorities, academics etc. – always with a view to also involve under-empowered sections of the population like migrants, women, older and young people.Alongside the mobility benefits for the action neighbourhoods, the project will result in a suite of products – most prominently the SUNRISE Neighbourhood Mobility Pathfinder – which will be provided to European cities, their stakeholders and citizens through a powerful exchange process to inspire and inform change across Europe. This will include a group of 20 Take-Up neighbourhoods and var
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional studies of a novel gene specifically up-regulated in breast cancer' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Bente Madsen has been a Ph.D.-student in my laboratory from August the 1st 1996 to July the 31st 1999; she has been working on gene regulation of the vasoactive intestinal polypeptide receptor type-l gene in breast cancer cell lines. She has with experimental and intellectual talent investigated two extensive projects, resulting in three first author papers, one published in Cancer Research. She has presented her data at international and national meetings both orally and as posters. She has furthermore, obtained a third position in an oral presentation competition for young scientists presenting her own data. Bente Madsen has during her Ph.D.-studies been able to set up new techniques as well as optimising excising techniques. She masters a wide range of molecular biology and biochemical techniques: including RNA analysis (Purification, Northern and slot blotting), Nuclear Run-on, transfection, luciferase assay, DNA cloning, DNA sequencing, PCR, RT-PCR, mammalian cell cultures, preparation of cell fragments, and binding experiments on membrane fragment and intact cells. In addition to her research work Bente Madsen has co-ordinated and supervised the work of undergraduate project students and laboratory technicians. Bente Madsen is a very energetic and hard working scientist. She always participates very active in scientific discussions and has as a scientist an analytical attitude to the results. She is bright and creative and her work is original; she is easy to get along with and is very popular with technologists. Ph.D.-students and postdocs in the laboratory. The Marie Curie Individual Fellowship will be of great importance for Bente Madsen future career. It will give her the opportunity to pursue her career in breast cancer biology in an Imperial Cancer Research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Seismic behaviour of precast concrete structures with respect to eurocode 8' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The research refers to the seismic behaviour of some innovative types of reinforced concrete precast structures, which have a wide diffusion all over Europe. The European norm for seismic design (Eurocode 8: ENV 1998-1-1/2/3:1994) as for now has no practical application for these structures, therefore the quantitative calibration of its rules is needed. The findings of the proposed research will be used to adapt Eurocode 8 provisions for the specific types of structures and in drafting the relevant requirements of the harmonised product standards under preparation by CEN/TC 229 (mandate M/l00). The objectives will be achieved by means of tests on full-scale prototypes and the associated theoretical interpretations. The experimental results will be used for the calibration of proper analytical models, with which a wide statistical investigation will be carried out for a reliable quantification of the behaviour factors"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'VALORISATION OF THE THERMAL RESOURCE DIRECTLY FROM THE WELLS OR AFTER THEIR USE FOR BALNEOLOGICAL PURPOSES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to valorize the geothermal resource produced by two old wells to be recovered in order to exploit 15-20 m³/h of hot water at 60°C. The combined utilization of the brine will be different depending on the spa season. The water will be used for building heating, manufacturing of sanitary hot water and to ensure the base load of a laundry with 10 T/day. The main positive environmental impact will be the discharge of water at lower temperature in the Dordogne river.The well Choussy II has been recovered has expected, recased with a mixed production casing (300 mm and 500 mm) and cemented to prevent fresh water to enter into the well. The production tests are successful with a total flowrate of 30 m³/h at 60°CThe main works consist in the recovery of two old wells:- deepening of well Choussy down to 84 m, setting a casing 9 5/8 cemented and adapted to the high temperature.- reconditioning of the well Perriere with a new casing 9" 5/8.The work over wil allow to produce 24h/24h the minimum of 15 m³/h, necessary to ensure the heating requirements of the installations.Three main uses are planned:- heating of the building 8 months per year,- production of sanitary hot water for 60 dwellings equivalent during 7 months per year,- preheating of laundry water during 10 months/year with 100 m³ of thermal water.The innovative part of the project is linked to the combined uses and cascade design which will permit the discharge of cooled water at 20°C in the environment."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Constructing line bundles on algebraic varieties -- around conjectures of Tate and Grothendieck' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The goal of this project is to investigate two conjectures in arithmetic geometry pertaining to the geometry of projective varieties over finite and number fields. These two conjectures, formulated by Tate and Grothendieck in the 1960s, predict which cohomology classes are chern classes of line bundles. They both form an arithmetic counterpart of a theorem of Lefschetz, proved in the 1940s, which itself is the only known case of the Hodge conjecture. These two long-standing conjectures are one of the aspects of a more general web of questions regarding the topology of algebraic varieties which have been emphasized by Grothendieck and have since had a central role in modern arithmetic geometry. Special cases of these conjectures, appearing for instance in the work of Tate, Deligne, Faltings, Schneider-Lang, Masser-Wüstholz, have all had important consequences.My goal is to investigate different lines of attack towards these conjectures, building on recent work on myself and Jean-Benoît Bost on related problems. The two main directions of the proposal are as follows. Over finite fields, the Tate conjecture is related to finiteness results for certain cohomological objects. I want to understand how to relate these to hidden boundedness properties of algebraic varieties that have appeared in my recent geometric proof of the Tate conjecture for K3 surfaces. The existence and relevance of a theory of Donaldson invariants for moduli spaces of twisted sheaves over finite fields seems to be a promising and novel direction. Over number fields, I want to combine the geometric insight above with algebraization techniques developed by Bost. In a joint project, we want to investigate how these can be used to first understand geometrically major results in transcendence theory and the