RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Re-envisioning risk biomarkers in acute myeloid leukemia (AML) at single-cell level' (AML), addressing dissemination and exploitation.

assistant: **Impact**

Acute myeloid leukemia (AML) is one of the most aggressive, clinically and biologically heterogenenous, hematological alignancies. The different genetics classify disease entities, and define the prognostic risk category to which AML patients are assigned and the treatment choices.There is one entity, the AML with nucleophosmin (NPM1) gene mutations, that accounts for onethird of all adult AML (the most frequent) and where another gene mutation - the Fms-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) - acts as ‘tip of the balance’ for patients’ risk definition, drastically worsening the prognosis and hanging treatment in those 40% of patients where it is detected. This has been a main field of research of Prof. Maria Paola Martelli and her team since years and specifically of her ERC consolidator grant ContraNPM1AML. Here, she will exploit concepts stemming from her ERC funded studies on the key role of kinases in the NPM1-mutated AML development, response to therapy and initiating relapse, and focus on that 60% of patients regarded at favorable prognosis, who nevertheless in 40% of cases will relapse with extremely dismal outcome. Currently, successful strategies to identify novel frontline key markers to refine risk are not available. reMARK-AML takes the challenge and changes prognostic risk parameters, pointing at re-envisioning the marker at single-cell level. A first strategy has been designed and will be tested for the proof-of-concept in patients in a prospective non-interventional study. We have established contacts with industrial partners for the development of fit-for-purpose diagnostic assay prototypes to test then in the study. The success of reMARK-AML will open the next challenge of developing marketable diagnostic kits and defining a st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Screening Database to Discover Donor-Acceptor copolymers for intramolecular Singlet Fission' to be submitted under Horizon 2020.

assistant: **Abstract**

Singlet fission is a multiple exciton generation process where a singlet exciton splits into two triplet excitons in adjacent chromophore centers, resulting in generation of two electron-hole pair carriers from each absorbed photon. Molecular systems displaying this phenomenon are very desired because they can, for instance, increase the efficiency of solar cells which must possesses both favorable energetics and appropriate electronic coupling. In this context, intramolecular bi-chromophores are particularly interesting in terms of their singlet fission capabilities. Specifically, these donor-acceptor copolymers have both proper electronic structure characteristics and modular molecular architecture. Nonetheless, no rational design principles exist for designing these systems, with the current state-of-the-art being based, primarily, on trial-and-error strategies. Thus, the field is ripe for the insight that can be brought by theoretical work, which has the potential to discover, in silico, new efficient singlet fission compounds.The objective of the D3AiSF project is to combine state-of-the art computational tools with fundamental concepts of quantum chemistry in order to advance the intramolecular singlet fission field through high-throughput screening of efficient donor-acceptor copolymers and quantum dynamics simulations. The project’s first step involves designing an automated workflow capably of screening large numbers of singlet-fission capable donor-acceptor copolymers based on energy and coupling descriptors. Afterwards, a second stage focuses on the singlet-fission performance of the very best potential candidates, which are evaluated in terms of real time quantum dynamics of the nonadiabatic process, which will ultimately validate their relevance. Overall, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamical processes in open quantum systems: pushing the frontiers of theoretical spectroscopy' (DYNAMO) under Seventh Framework.

assistant: **Objectives**

Scope ""Energy Materials. In  this project we develop new concepts for building a novel theoretical framework (the ab-initio non-equilibrium dynamical modelling tool”) for understanding, identifying, and quantifying the different contributions to energy harvesting and storage as well as describing transport mechanisms in natural light harvesting complexes, photovoltaic materials, fluorescent proteins and artificial (nanostructured) devices by means of theories of open quantum systems, non-equilibrium processes and electronic structure. We address cutting-edge  applications along three major scientific challenges: i) characterize matter out of equilibrium, ii) control material processes at the electronic level and tailor material properties, iii) master energy and information on the nanoscale. The long-term goal is developing a set of theoretical tools for the quantitative prediction of energy transfer phenomena in real systems.We will provide answers to the following questions: What are the design principles from the environment-assisted quantum transport in photosynthetic organisms that can be transferred to nanostructured materials such as organic photovoltaic materials and biomimetic materials? What are the fundamental limits of excitonic transport properties such as exciton diffusion lengths and recombination rates? What is the role of quantum coherence in the energy transport in photosynthetic complexes and photovoltaic materials?  What is the role of spatial confinement in water and proton transfer through porous membranes (nano-capillarity)?The ground-breaking nature of the project lies in being the first systematic development and application of the theories of open quantum systems   and quantum optimal control within an ab-initio framework (time-dependent-densi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Oxidation resistant al and ptal diffusion coatings with improved oxidation and thermomechanical fatigue life' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Turbine blades of aero engines are coated for oxidation protection. New Al and PtAl diffusion coatings shall be developed with improved and balanced oxidation life and mechanical performance. Coating composition, structure and defects will be modified and active elements will be incorporated. The environmentally friendly, safe and cheap out-of-pack process will be further developed to produce the new coatings without expensive heat treatment. Active elements shall be included simultaneously with aluminising. Oxidation and mechanical properties will be investigated. Basic understanding will be gained to give guidelines for coating and process development. New coatings will be tested in demonstrator engine and on-wing. The partners are involved in research, design, production, repair and Use of aero-engines and come from 6 countries. They are qualified to transfer the technology to industrial use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of cost effective pemfc for automotive applications (OPTIMERECELL)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The industrial objective of the project is to use the developed and optimised fuel cell technology for the realisation of a 10 kW PEMFC stack designed and manufactured with a special attention on the cost reduction and working at temperature around 120-130°C with hydrogen containing up to 200 pip CO. Particular attention will be paid to reduction of the weight and the volume occupancy. The Pelf's obtained will be tested to check their capacity for generation of the electric energy. The potential and current will be measured in a membrane electrode assembly and correlated with the heat and water balance of the system. The optimum conditions of the PEMFCs manufacturing will be established during the project and will be completely orientated to the cost reduction and the industrialisation capacities thank to the experience of car manufacturers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Generation of cartilage-free kidney organoids: a small molecule strategy' under Horizon Europe.

assistant: **Concept**

The prevalence of chronic kidney disease in Europe varies from 3.3–17.3% and has risen during the last decades. In the world, 9.7 million people need kidney replacement therapy, but only 2.6 million will receive it. These numbers are expected to double within the next 10 years, increasing the pressure to find alternative solutions. Recent scientific developments to generate kidney organoids in vitro have opened the possibility for a regenerative medicine–based approach that would provide a functional substitute to the failing kidney. These kidney organoids can recapitulate renal structures as well as the cellular complexity of human kidney, and may restore glomerular filtration upon transplantation. In this project, we make use of human induced pluripotent stem cells that can be differentiated with a cocktail of biomolecules and aggregated to form of kidney organoids that are cultured at the air–liquid interface. This protocol leads to the formation of complex renal structures including glomeruli and tubules. While kidney organoids show great therapeutic potential, they also present several drawbacks, one of which is the appearance of off-target cell populations, such as neurons, myocytes and chondrocytes within the organoid. Preventing the appearance of these off-target cells will greatly improve the quality of the organoids. Preventing cartilage formation is most desirable because cartilage completely disrupts the organoids and renders them dysfunctional and unsuitable for in vivo use.The reasons for the consistent observation of chondrocytes during organoid growth and transplantation are not yet understood. The objective of this work is to understand the molecular mechanisms of cartilage formation in kidney organoids and reduce it using a small molecule strategy.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SYMBionts in Insect Societies: reproductive manipulation and the fitness effects of Wolbachia in leaf-cutting ants' (SYMBIS) under Seventh Framework.

assistant: **Objectives**

Social insects include some of the most ecologically dominant species in both temperate and tropical areas, and represent a major evolutionary transition in the development of complexity. Insect societies are consequently of considerable interest for biologists and the general public. One emergent field of special interest is the interaction between social insects and their parasites both because of the role these are likely to have played in the evolution of sociality in insects and the parallels with the challenges presented to our own societies by disease. However, most studies of social insect parasites have been limited to those that cause obvious symptoms of infection, whereas many are more cryptic. These include the ubiquitous bacterial parasite Wolbachia which has been the subject of an explosion of research in non-social insects in recent years. This project will use leaf-cutting ants as a model system to examine for the first time experimentally the fitness effects of Wolbachia infections in social insects. It will involve interdisciplinary collaboration and advanced training in key scientific skills (ecology and population genetics) that my molecular genetic PhD did not include. The fellowship will greatly enhance my potential for achieving a position of professional maturity and independence as a broadly trained biologist.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel materials for silicate-based fuel Cells' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The main scientific objective of the MatSILC project is to develop an alternative concept of SOFCs based on novel low cost silicate based electrolytes, and suitable processing technologies for the corresponding cell components. This project has the potential to overcome some degradation problems associated with SOFCs based on alternative electrolytes, such as contamination of YSZ or CGO with silica.Some of the silicate electrolytes are also unique model materials for transport mechanism of interstitial oxygen ions. By changing the acid-basic nature of the electrolyte phase, one might also contribute to enhance the electrocatalytic performance of related metal/electrolyte cermet anodes, and to minimize critical limitations of sulphur contamination and carbon deposition in contact with hydrocarbon fuels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understanding the physics of first-year sea-ice growth using theoretical and computational fluid dynamics' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Sea ice provides a dramatic indicator of climate change, and is central to significant feedbacks on climate processes, weather, and polar biogeochemistry. The recently observed imbalance in the annual cycle of winter ice growth and summer melt results in a declining sea ice cover, with first year ice forming a larger fraction of the ice cover instead of the thicker multiyear ice that has been prevalent in the past. Hence, first year ice processes become increasingly important.This project will advance the state of the art in modelling of physical processes controlling sea ice growth, by applying theoretical and computational fluid dynamics tools to study 2 key elements of first year sea ice growth:1. Sea ice forms a reactive porous material of ice crystals and liquid brine, allowing fluid transport through the ice and exchange of salt and chemicals with the ocean. We will develop numerical models to directly resolve fluid flow through the interior of a growing ice layer using a continuum theory for multiphase materials. Time-dependent simulations of convection in the ice pore space will yield new insight into brine drainage from sea ice.2. A significant fraction of Antarctic sea ice has a granular texture, formed by aggregation of ice crystals that grow in turbulent waters below the ocean surface. We will develop novel direct numerical simulations of particle-laden flow with crystal growth and aggregation, to quantify the dynamics of granular ice formation.The resulting modelling tools, simulation data, and physical insight gained will complement existing observational and experimental data, and provide a basis for developing and evaluating parameterisations for climate prediction and models of sea ice biogeochemistry.This CIG project will develop a new research team on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Implementation of a cord blood allocation network' to be submitted under Fifth Framework.

assistant: **Abstract**

Residual blood from the umbilical cord of neonates (cord blood, CB) has become unimportant alternative to bone marrow as source of transplantable hematopoieticstem cells in the treatment of leukaemia and other diseases. To support the CBspecific advantages over other stem cell sources an adequate allocation mechanism must be implemented. It is imperative to minimise the duration of the allocation procedure. This will have direct positive impact to the transplantation outcome and therapy costs. The implementation of a cord blood allocation network by using modern workflow management tools will ensure an equal chance for each patient togged the best transplant available and, thus, solve possible allocation conflicts. By constantly analysing the systems operation a cyclical mechanism is fed to improve the allocation process and the quality of service. The deployment of such quality chain is also part of the objectives of the study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Isotopic evidence for diet and mobility during the Neolithic transition to farming in the Near East'.

assistant: **Objectives**

The Neolithic transition represents perhaps the most significant development in human history. In Europe the ‘Neolithic package’ arrived as a whole, and has been studied in detail using isotopic and genetic methods, but few isotopic studies have addressed the earlier and more complex transition in the Near East. Thus currently we know little about the changes in diet and mobility of individuals and cannot compare this crucial region to the later transition in Europe or to parallel transitions elsewhere. ISONEO will investigate the composition of diet in selected Neolithic populations of the Near East using carbon and nitrogen isotope analysis. Using strontium and oxygen isotopes in human tooth enamel ISONEO will explore the importance of migration in creating and sustaining the population of Pre-Pottery Neolithic B megasites and in the lifeways of the desert populations of the Pottery Neolithic and Chalcolithic in Jordan, Israel, and NW Saudi Arabia. The main sites used will be ’Ain Ghazal, Basta, Ba’ja, Kharaysin, Mallaha, Beisamoun, and Shubayqa. The results will be used to build a regional model of the diet, mobility and social changes that took place during the Neolithic transition in the Near East in a holistic synthesis with previous research based on traditional archaeological evidence including archaeobotany and archaeozoology. The Experienced Researcher, Dr Jonathan Santana will be supervised and trained by Dr Andrew Millard. Within the research intensive context of the Department of Archaeology at Durham he will enhance and expand his existing research skills, knowledge of practical techniques, and theoretical knowledge. He will be trained in stable isotope analysis and the interpretation of isotopic data, which will enable him to undertake the research for IS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A new platfoRm for eXplorIng Magnonics interfacEd with ultracolD nEutral atomS for quantum information' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ARXIMEDES’ ambition is to establish a novel  neutral atom-magnon platform towards on-chip quantum information processing (QIP) and quantum simulation at 300 K.  It will explore the braiding of magnonics e.g. spin waves with cold matter: First, by harnessing the spin wave’s tuneable stray field of a standing spin wave pattern to trap ultracold neutral 87Rubidium (Rb) atoms on chip via magnonic lattice potentials. Second, by controlling the atoms  & their interactions via magnonics.  The absence of electrical current generating the trap will overcome today's challenges of miniaturized atom chips such as heating and decoherence from the trap. Third, the subsequent constitution of a new “magnonic lattice toolbox” which contains all ingredients to individually control and manipulate atoms will pioneer on-chip sensing, QIP and quantum simulation (by exploiting the frequency tunability and phase control of magnonics to move atoms by coupling to spin waves or to tune the lattice for Floquet band engineering). ARXIMEDES’ compact atom-magnon chip will uniquely combine the scalability, tuneability and controllability of magnonics with the  advantages of neutral atom qubits (e.g. long coherence times, low error rates). ARXIMEDES will thus establish new avenues for QIP and quantum simulation for many-body physics by studying very short-range atom interaction regimes (via wide lattice spacing tunability for sub-wavelength lattices e.g. to engineer artificial gauge fields). Further, magnon-atom interactions in the linear or nonlinear regimes will be explored for the first time as well as extending state-of-the art magnonics by the new roles of spin wave interference, pulses and propagation in ARXIMEDES.  Together with these new insights to fundamental physics, ARXIMEDES unique idea wi