RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Lifting up the working poor: predistribution and redistribution at the low end of the wage spectrum'.

assistant: **Concept**

Minimum wages and taxes and transfers are prominent examples of pre and redistributive policies in the area of low pay in Europe and the U.S.Despite their pervasive coexistence and extensive research on their effects, the two have been mostly studied in isolation. This has limited our ability to evaluate their interplay in the labor market and identify joint design options to effectively support the working poor. With these goals, our first contribution is to examine the pre and redistributive components of low-income support jointly. We will develop an empirically grounded model of the low-wage labor market, which can be used to evaluate the impact of alternative joint designs of minimum wages and taxes on labor market equilibrium in a realistic way. This requires new empirical evidence on how the two interact and on the fundamental features of the market environment in which they operate.Minimum wages are widely popular, although according to standard normative theory their existence is not justified if governments can redistribute with taxes. Why, then, are minimum wages so socially and politically successful? Our second contribution is to uncover what drives support for pre and redistribution to the working poor. Besides enriching our knowledge of the political feasibility of reforms in this area, evidence on policy preferences will be central to characterizing an optimal redistribution policy based on a new notion of welfare desirability, which considers not only the material interest of individuals as market participants, but also their policy preferences as citizens.Academically, this is groundbreaking since it overcomes multiple empirical and theoretical divides in both positive and normative analysis, with the end goal of characterizing the optimal configuratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Genomics Initiative on Disorders of plasma membrane Amino acid Transporters' in the context of a Sixth Framework call.

assistant: **Objectives**

The project EUGINDAT is an integrated approach that links genetics, biochemistry, physiology, genomics, proteomics, structural biology, drug development and clinical studies in an attempt to improve understanding and treatment of Primary Inherited Aminoacidurias (PIA). PIA are rare diseases involving defects in renal reabsorption of amino acids that also affect other organs. The generation of amino acid or peptide transporter-deficient mice will have an impact on our knowledge not only of renal reabsorption but also nutrition, and pathological states such as certain forms of cachexia and selected disorders of the central nervous system. The main objectives are: 1) To complete a clinical and molecular-genetic description of PIA with the generation of a European PIA-DATABASE including: Cystinuria, Lysinuric Protein Intolerance (LPI), Dicarboxylic Aminoaciduria (DA), Hartnup Disorder (HDis), Iminoglycinuria (IG) and unlabeled aminoacidurias". The proposal aims to study candidate genes for cystinuria, DA, HDis and IG. 2) To gain a thorough knowledge of the molecular structure of relevant transporters using 2D crystals of prokaryotic, and eventually eukaryotic, homologues and 3D crystals of water-soluble extracellular domains. 3) To complete a functional genomic study of relevant transporters underlying PIA and renal reabsorption of amino acids. 4) To identify genes and/or loci that affect cystinuria lithiasis, and may eventually explain gender-related and individual variability in stone-forming activity in patients with cystinuria. 5) To develop new therapeutic strategies for cystinuria lithiasis. 6) To identify the mechanisms contibuting to the pathology of LPI which explain the hepatic phenotype (hyperammonemia) and the immune system-compromising symptoms. 7) To test new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Towards a Third Nuclear Age? Strategic Conventional Weapons and the Next Revolution in Global Nuclear Order'.

assistant: **Concept**

The world stands on the cusp of a major transformation in nuclear affairs. This paradigmatic shift is being driven by the development and deployment of an entirely new class of strategic weaponry, facilitated by the latest information revolution. The most important characteristics of these weapons are that they are all hi-tech and non-nuclear; that they can be used against an adversarys nuclear forces, and that they are increasingly able to augment and even replace nuclear weapons for key national security functions. Taken together, we can think of these of these systems as Strategic Conventional Weapons (SCW), and as representing a fundamental challenge to the way that our nuclear world is managed.   SCW raise questions about deterrence strategy, mutually assured destruction, future arms racing and arms control, and how best to retain and maintain global nuclear stability and peace. NUCLEARREV will therefore provide the first ever systematic scholarly study of SCW, make the case for a paradigmatic shift in nuclear studies, set the stage for a complete rethinking of the global nuclear order.  The main research question is: How will Strategic Conventional Weapons change the Global Nuclear Order? To answer this the objectives are to: Chart the SCW phenomenon, globally; Analyse how SCW will impact regional nuclear relations and balances; Examine what the development of SCW means for the frameworks and dogma that govern international nuclear relations; Make the case for a revolution in nuclear affairs and define the embryonic Third Nuclear Age. This urgently required research will provide the landmark study of this phenomenon and the centrepiece for a whole new generation of interdisciplinary and multidisciplinary work on nuclear affairs.  The project combines interviews wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanism of Whi3 Aggregation and its Age-dependent Malfunction' (MemoryAggregates), addressing dissemination and exploitation.

assistant: **Impact**

Age-associated neurodegenerative diseases are characterised by the irreversible pathological aggregation of proteins with low complexity (LC) sequences. In contrast, cells can exploit LC protein aggregation to help them adapt to changing environments. The factors that determine whether an aggregate is functional or pathological are unclear. How do cells control protein aggregation? Are age-associated diseases caused by loss of control over functional protein aggregates? To address these questions, we will study how yeast cells induce aggregation of Whi3, an LC RNA-binding protein, in order to memorise failed mating attempts. Using mass spectrometry, fluorescence microscopy and biochemical assays, we will determine whether post-translational modifications, RNA-binding and protein sequence affect Whi3 aggregation and function. We will then characterise the material properties and structures of Whi3 aggregates using cryo-electron tomography. Once we understand how cells control Whi3 aggregation, we will investigate whether this regulatory mechanism deteriorates in old cells, and whether the properties and structures of age-induced aggregates differ from their functional counterparts. These studies will improve our understanding of the largely unexplored phenomenon of functional protein aggregation, and how ageing promotes the uncontrolled protein aggregation underlying neurodegenerative diseases.


**Keywords:** Protein aggregation,  Ageing,  Phase transition,  Prion,  Single-cell memory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fundamental Research into Understanding the Molecular structure of eleKtrochemical INterfaces'.

assistant: **Objectives**

The FRUMKIN project aims to develop and test a new model for the electric double-layer structure of the electrode-electrolyte interface and to investigate the impact of this double-layer structure on the kinetics and selectivity of electrochemical and electrocatalytic reactions. The inspiration for this new model comes from my own recent work that the classical Gouy-Chapman-Stern model for the electric double layer fails to properly describe the interface between an aqueous electrolyte and single-crystal platinum and gold electrodes. Specifically, our results indicate that there is an attractive interaction between ions and the electrode surface (unaccounted for in the Gouy-Chapman-Stern theory) that accumulates ions in the diffuse double layer, and that ions in the double layer interact with the electrode and with themselves through water-mediated hydration forces, approximately following the Hofmeister series. These effects are observed even for low electrolyte concentrations, explaining the invalidity of the Gouy-Chapman-Stern theory.The FRUMKIN project will approach its research objectives using a variety of high-level experimental, spectroscopic, theoretical, and computational techniques. The heart of the experimental work is based on ac voltammetry, i.e. differential capacitance measurements of the various interfaces, and electrochemical measurements of reactivity. Modelling of the experimental differential capacitance curves is based on first-principles DFT calculations and coarse-grained free-energy-based classical density functional simulations of the double-layer properties. Experimental molecular details of both double-layer structure and reactivity will be obtained from in situ vibrational spectroscopy (Infrared and Raman) and advanced in situ X-Ray spectros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Proof of Principle of the best-in-class therapeutic mRNA cancer vaccine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

TIGER delivers proof of principle (PoP) in humans for a novel best-in-class therapeutic mRNA cancer vaccine platform optimized for intravenous (IV) administration, with the aim to show clinical benefit. The antigens used for the PoP consists of mRNAs encoding the proteins E6 and E7 of Human Papilloma Virus strain 16 (HPV16), and TriMix mRNAs that act as adjuvant to stimulate dendritic cells to start strong T cell responses. The mRNAs will be formulated in a novel patented lipid nanoparticle shielding the mRNA, and delivering it to immunoactive antigen presenting cells, vastly enhancing T-cell response. Safety and potent efficacy of our IV mRNA product have been demonstrated in rodent experiments. Furthermore, preclinical to clinical translation has been shown for our TriMix based vaccines using different delivery strategies. Based on the preclinical and prior clinical data, our platform has the potential to cure cancer patients.The PoP study will be in patients with recurrent HPV16 positive cancer, which is categorised as a non-communicable disease by the WHO, without and with a PD-1 checkpoint inhibitor.  Safety, immunogenicity and clinical benefit will be key endpoints of the study. Biomarker and PROM research will allow future informed therapeutic and care decisions by both patient and care team. Recruitment and stratification plans will be in place. Interactions with regulatory, reimbursement and ethical authorities together with patients and carers will help laying out the route to the patient not only for our product but also for all other mRNA cancer vaccines. The project encompasses essential elements for preparing therapy validation in later stage clinical studies, while addressing patient needs, values and choices. Upscaling of GMP-production for IV mRNA vacci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Geographical index system', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objective of GEOINDEX is to : 1. Conduct a feasibility study of creating a platform for integrating information in existing databases with a dynamic map based three-dimensional index. 2. Perform a market analysis in order to define and quantify the potential demand for and impact of such a platform.The platform will allow developers, authors etc. of SMEs as well as super users of larger organisations to create specific applications for searching and displaying data from existing sources in a user freindly manner. The platform gives an opportunity to create relationships between external databases from different providers. The platform will also give the opportunity to display the result of these queries on 3D maps. The display tools will therefore have the ability to integrate vector and bitmap information in various cartographic projections and combine them with elevation data to give the ability to display the results in 3D fly through. Throughout the years numerous organizations have undertaken the task of collecting tremendous amounts of alphanumeric and map data. It is obvious that society would benefit from an easy and standardised method of accessing and integrating this data. GEOINDEX will investigate which specific tools are needed in order to meet such a market requirement. GEOINDEX will additionally quantify the size and segment of such a potential market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evidence and opportunities for responsible innovation in SMEs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The challenge of the COMPASS project is to collect and deploy evidence on how RRI can be meaningfully integrated into extant innovation systems in European industry. COMPASS will pursue three overarching objectives: Providing evidence for better uptake of RRI in industrial R&D&I, fostering collaboration in three key innovation fields (healthcare, nanotechnology, ICT) and promoting responsible and sustainable R&D&I governance of highly innovative businesses.To achieve these objectives, COMPASS will build upon previous research and best practice cases on RRI, CSR and sustainable business models. It will involve industry, research and civil society in co-creation processes from very early on in order to ensure usefulness, feasibility and ownership of results among the target communities. The ultimate aim of the project will be to develop, pilot test and finalise an interactive online platform, the Responsible Innovation Compass. The platform will deploy RRI visions and roadmaps for the three innovation fields, a Responsible Innovation Self-Check Tool for SMEs as well as audio-visual training materials and tutorials, short thematic guides, additional resources and promotional materials. It will provide guidance and orientation tailored to the needs of innovative enterprises, particularly SMEs.COMPASS aims to substantially increase the evidence base for benefits of the inclusion of RRI into industrial R&D&I, through integrating findings of previous projects, systematically collating the extensive stock of knowledge dispersed across communities of practice, analysing empirical evidence on critical responsibility issues, success factors, and barriers for adoption of RRI in industry and pilot testing the added-value of all content of the project’s Responsible Innovation Compass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Planning the Future of Research & Innovation in the European University Alliance UNITE!'.

assistant: **Concept**

UNITE! is one of the first 17 European University Alliances. Back in 2019, our 7 universities decided to take institutional cooperation to the next level by developing a long-term joint strategy for education addressing societal challenges offering inter-university ‘campus’ curricula where students, doctoral candidates, faculty and staff are mobile at all levels.Through this UNITE!H2020 project, our Alliance looks even further and takes up the challenge launched by the EC to develop, in synergy with its education dimension,  a shared, integrated, long-term research and innovation (R&I) strategy, while developing, during the 3-year of the project, several pilot initiatives in the field of Energy - with special reference to the Green Deal - and Industry 4.0.UNITE! universities are highly ranked in their shared focus areas - STEM, architecture and design, and all belong to the CLUSTER university network, which boasts three decades of close cooperation among its members. This gives us a position of strength in assuring tangible progress towards our institutional transformation and the identification of successful models for the modernization of R&I. To do so, UNITE!H2020 will: a)develop a common R&I 2030 agenda, emphasizing our common DNA and shared vocation to address major societal challenges;  b)develop policies to strengthen our R&I human capital by, e.g., new career development initiatives; c)develop policies to share our research infrastructures (RIs) supported by, e.g., experimental tests of previously developed guidelines on a selection of Energy RIs; d)reinforce cooperation with non-academic R&I players by, e.g., developing a network of Grant Offices & TTOs; e)mainstream our comprehensive Open Science  practices based on, e.g., a detailed experimental analysis on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A novel approach to fermionic models in lattice field theory' (1994-1998).

assistant: **Concept**

Presently, my work under the HCM contract ERBCHBGCT930470 is concerned with the study of aspects of the dynamical fermion problem. It is based on a paper by Salmhofer who demonstrated the exact equivalence of the one-flavour strong coupling lattice Schwinger model with Wilson fermions to a self-avoiding loop model. I have successfully applied the above exact equivalence to obtain previously unknown information about the critical behaviour of the strong coupling Schwinger model. The method of Salmhofer however can equally be applied to strong coupling QED with any number of flavours as well to any purely fermionic system with Wilson fermions in any dimension. Presently, I further investigate the case of strong coupling QED. The objective of the proposed project consequently is to study the method of Salmhofer for purely fermionic systems. The project will shed new light on the dynamical fermion problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Common Agriculutral and wider bioeconomy reSearch Agenda' (CASA) under Horizon 2020.

assistant: **Objectives**

The overall objective of CASA is a consolidated common agricultural and wider bioeconomy research agenda within the European Research Area. The common research agenda will be jointly shared by Member States of the European Union and Associated Countries. It will improve the alignment and interoperability of the respective national research programme(s). This will be achieved through enhanced cooperation, coordination and information exchange between the Member States, Associated Countries and the European Commission. This includes increasing the opportunities for Member States and Associated Countries to engage in the aforementioned activities. The conduit for this will be the Standing Committee of Agricultural Research (SCAR) and the various SCAR working groups, through which all Member States and Associated Countries are brought together with a view to fostering cooperation, coordination and information exchange, as well as streamlining research policy, in the bioeconomy and closely related fields.The overarching aim of CASA will be achieved through the accomplishment of the following four specific objectives:1. Increased and broadened participation, interaction and collaboration of Member States and Associated Countries2. Improved quality of outputs and outcomes of the Standing Committee of Agricultural Research creating added value for greater impact3. Strengthening the production of more strategic policy advice by the Standing Committee of Agricultural Research based on the increased, deepened and broadened participation facilitated by CASA4. Improve overall organisation, communication and dissemination of SCAR activities, outputs and outcomes for greater impact


**Keywords:** bioeconomy, coordination, alignment, research, innovation, ERA-NET, JPI, Member States,