RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Aeronautical Training Network in Aerodynamic Noise from Widebody Civil Aircraft' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A new Aeronautical Training Network is proposed to train Early Stage Researchers and Experienced Researchers in front-line, integrated, industry relevant research in unsteady aerodynamics and noise for the next generation of environmentally friendly wide-body civil aircraft. Building upon the multi-host EST FP6 programme AeroTraNet, AeroTraNet 2 clusters the complementary expertise of 5 established European academic institutes, 2 EU multi-national companies, 1 SME, and one national research centre to offer structured, flexible, well-integrated, a la carte, doctoral and post-doctoral training programme for the new generation of EU aerodynamics and noise specialists. Six academic partners address the common objective of modelling shock cell noise in a wide-body aircraft engine configuration from private sector partner Airbus France, by shock-tolerant numerical modelling for under-expanded jets (ULEIC), large eddy simulations for turbulent jets with weak shocks (Cerfacs), advanced flow-noise correlations (UNIROMA TRE), jet and near-field noise experiments (VKI), reduced-order modelling and flow control (IMFT-INP), and advanced laser-based measurement techniques (INSEAN). Knowledge output is synthesized through a dedicated knowledge capturing programme by UoG, which is used by private sector partner Alstom UK. In AeroTraNet 2, the research output becomes itself object of knowledge management research, which is a novel supra-disciplinary element. By combining their well-established doctoral training schools and graduate training programmes, the academic and industrial partners will train a well-integrated team of 9 ESR and 3 ER who have learnt to combine their different research techniques to push forward the state of the art of shock cell noise prediction applied to aircraf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Creating high impact for CAPS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ChiC is a game-changing Coordination and Support Action aiming at maximizing the impact of the ICT-10 2015 projects and transforming CAPS in an Innovation Ecosystem. The consortium brings together well-experienced partners which can count on the lessons learned and the network acquired in on-going FP7 CSAs (in the CAPS field and beyond): this sound foundation will make us move the CAPS Programme one step further from day 1. In the last couple of years, CAPS-centered projects and initiatives have been successfully initiated and pursued by an increasing number of innovative and diverse players, including industry, academia local communities, grassroots activists, hackers, social entrepreneurs, students, citizens, creative industries and civil society organizations. There is a strong need to coordinate these efforts so as to maximize their impact for the whole European society.This is where the Creating high impact for CAPS (ChiC proposal comes with the ambition to act as a bridge between all CAPS-driven efforts and players, including the EC representative and related EU initiatives. ChiC is an ambitious 30 months CSA that groups a small, but very dynamic team of well-experienced players in the CAPS and related domains, which are committed to create broad impact on the basis of a well-structured and articulated work plan.ChiC will coordinate and support experimental and scientific efforts within the CAPS context to maximise their impacts and reach beyond current players for effective involvement and engagement of new stakeholders. The ambition of ChiC is to support the various CAPS and related projects by offering them concrete opportunities for networking, know-how sharing/exchange and effective promotion of their work and result, but also to ensure that the CAPS programm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Co-operative multidimensional multimedia topological elements reintegration' (COMMUTER) under Fourth Framework.

assistant: **Objectives**

Public administrations are using highly distributed information and data for purposes of ensuring public security, citizen comfort and city management in general. They have a wide range of data bases containing, statistical Geo-referenced data. Such information and data is of paramount importance. It is essential that it is maintained and kept up-to-date. Many European public authorities are demanding a new type of system which can provide a distributed and co-operative update management of Geo-related information, and, at the same time giving a secure continuity to legacy departmental systems. This new demand of GIS services in standard information system is going to create a new series of Geo-technology. Existing data base update solutions are vendor dependent underlying relational database system giving access to proprietary repository.In this context the goal of the project is develop software services to support integration of Geo-data transformations and to support transactions that can be executed by remote distributed servers in a transparent way and to demonstrate and assess the usability of the system. For this purpose, four user organisations (from France, Italy and Germany) are directly participating in this project. They have been chosen because as representative sample of this business sector concerning the size (due to large volume of information and data that are dealt with), and geographical coverage. It will enable continuity of office databases, avoid users manually transferring data between their workplace and the central data bases office and enhance the use of updated information.COMMUTER services are realised on the top of the following: information access and retrieval, exploration enabling, real-time or differed-time updating and feedback-genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pre-receptor cortisol metabolism and human ageing' under Seventh Framework.

assistant: **Concept**

The number of people over the age of 80 years in the 25 EU member states is currently 18.2 million or 4% of the total population; by 2020, 20% of the EU population will be >65 years old which will place considerable burden upon limited health care resources. 70% of older adults report at least one chronic disease that contributes to a reduction in healthspan or the number of extra years spent in good health. The European Commission is committed to identify rational and evidence based approaches to improve health in old age and as such has identified Ageing research as a priority. The most prevalent conditions that contribute to the ageing phenotype are sarcopaenia, hypertension and cardiovascular disease, central adiposity and type 2 diabetes mellitus and osteoporosis. Here there are remarkable similarities to patients with Cushing s syndrome caused by excessive secretion of glucocortiocoids such as cortisol. PRECORT Prereceptor Cortisol metabolism and human Ageing will test the hypothesis that age-related changes in body composition (central adiposity, reduced bone and muscle mass, skin thinning) and resulting chronic disease (diabetes, osteoporosis, sarcopaenia, hypertension, cardiovascular disease) are caused by excessive glucocorticoids as a result of age-related activation of the pituitary-adrenal axis and/or increased 11b-hydroxysteroid dehydrogenase type 1 (11b-HSD1), an enzyme that can generate cortisol locally within fat, bone, muscle and skin. The proposal will complete the full cycle of translational research and will potentially offer a new therapeutic approach through selective 11b-HSD1 inhibitors to modulate the ageing phenotype thereby improving the healthspan of the Ageing EU community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Diabetic Brain' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Type 2 diabetes is one of the most common chronic diseases in the world, and the number of those affected has been raising dramatically in recent years. In type 2 diabetes the body fails to use insulin effectively, which leads to the chronic increase in blood glucose that characterises the disease. It is not known why the body becomes resistant to insulin but evidence suggests that an imbalance between energy intake, storage, and expenditure can lead to obesity and insulin resistance. Thus, to understand the origins of diabetes it is fundamental to understand how the organism evaluates and controls its metabolic requirements. The hypothalamus in the base of the brain is essential for orchestrating such functions, aided by specific cell groups which detect changes in extracellular levels of nutrients. I suggest that a disruption in these sensing mechanisms in the hypothalamus can lead to a metabolic imbalance in the body. In this project I will study the properties of hypothalamic nutrient-sensing neurones in a model of obesity and insulin resistance. A novel approach that will combine state-of-the-art cell physiology, biochemistry, cellular and mitochondrial bioenergetics, and molecular imaging methods in a multidisciplinary environment will be key to unravel some of the mechanisms used by nutrient-sensing neurones in health and disease. This project will thus provide a better understanding of the role of these mechanisms in obesity, insulin resistance, and diabetes. That knowledge will potentially open new avenues to the development of novel strategies for treating metabolic diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Forum for Integrated Infrastructures Initiatives'.

assistant: **Innovation**

The I3 Forum is a forum open to all of the Integrated Infrastructure Initiatives (I3), and Infrastructure related Coordination Actions (CA) funded by the Research Infrastructures action of the 6th Framework Programme. Between them these I3 and CA represent most of the large research infrastructures in the European Research Area, with an enormous combined research capability and capacity which is of considerable importance for Europe's future prosperity. The I3 FORUM has four main objectives:* To exchange good practice in the management and organization of I3, both ongoing through FP6 and providing feedback to the Commission relating to FP7. * To exchange information and expertise in areas of common interest, e.g. approaches to Science and Society activities. To act as a central information service regarding the role and importance of major research infrastructures in general and to develop common approaches/solutions to common problems. * To explore possible synergies between I3, including the possibility of joint activities (e.g. JRA).* To act as a central contact point for information concerning the development of a European infrastructures roadmap, through specific links to ESFRI and ESFRI working groups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing Multispecific Biological Agents that Target Tumor Neovasculature for Cancer Imaging and Therapy' in the context of a Seventh Framework call.

assistant: **Objectives**

The dysregulation of signaling pathways that mediate cell proliferation, survival and migration is an underlying cause of many cancers. In particular, dysregulation and over-expression of avb3 integrin, membrane-type-1 matrix metalloproteinase (MT1-MMP; also known as matrix metalloproteinase-14, MMP14) and vascular endothelial growth factor receptor-2 (VEGFR2) correlate with poor prognosis in many human tumors, making these proteins attractive targets for therapeutic intervention. Numerous papers have demonstrated the cross-talk between biological processes mediated by αvβ3 integrins, MT1-MMP, VEGFR2, and their ligands, particularly pathways responsible for angiogenesis. Dual-specific proteins that can target and inhibit the activity of the above multiple receptors therefore have superior potential to single-targeted agents due to differential expression of these disease markers in different patients and the ability of this expression to change over time. Most currently available bispecific protein therapeutics comprise antibodies (Abs) or antibody fragments. The new approach proposed here entails rational and combinatorial methods for engineering multispecificity into small peptides and natural protein ligands to function as non-immunoglobulin alternatives to antibodies. In this innovative approach to creating dual-specific proteins, an additional functionality is introduced into a small peptide or into a natural protein ligand to complement its existing biological properties. We predict that this approach will form a major part of a highly effective strategy for creating ligand-based multispecific receptor inhibitors and molecular tools for protein recognition. We envision that protein variants generated from these efforts will promote the next generation of therapeut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Arrowhead Flexible Production Value Networks' under Horizon Europe.

assistant: **Concept**

The Ambition for Arrowhead fPVN project is Doubling of the European industrial productivity by applying transformative, autonomous and evolvable information interoperability for resilient and adaptive production value networks. Hence,  the Arrowhead flexible Production Value Network (fPVN) project will provide autonomous and evolvable interoperability of information through machine-interpretable content for fPVN stakeholders. The resulting technology is projected to substantially impact manufacturing productivity and flexibility.Autonomous and evolvable interoperability will be achieved through common project technology based on three pillars:1. Microservices paradigm,2. Utilization of major industrially accepted data models, 3. Automatic translation between the data models.The common technology will be validated and verified in 11 use cases covering the production value networks in the following industrial production domains:• Semiconductor production,• Automotive services,• Aerospace services,• Green energy conversion, and • Process industry production.The results are expected to considerably impact the efficiency of both local and global production value networks thanks to substantial cost and time reduction for setting up, operating, and managing the interactions within production value.


**Keywords:** Interoperability, Autonomous translation, Information models, Micro-services, Semiconductor, Automotive, Aerospace, Energy, Process industry, Productivity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Revolutionary Design of Spacecraft through Holistic Integration of Future Technologies' (ReDSHIFT) under Horizon 2020.

assistant: **Objectives**

ReDSHIFT will address barriers to compliance for spacecraft manufacturers and operators presented now and in the future by requirements and technologies for de-orbiting and disposal of space objects. This will be achieved through a holistic approach that considers from the outset opposing and challenging constraints for the safety of the human population when these objects re-enter the atmosphere, designed for demise, and for their survivability in the harsh space environment while on orbit. Ensuring robustness into the future, ReDSHIFT will take advantage of disruptive opportunities offered by 3D printing to develop highly innovative, low-cost spacecraft solutions, exploiting synergies with electric propulsion, atmospheric and solar radiation pressure drag, and astro-dynamical highways, to meet de-orbit and disposal needs, but which are also designed for demise. Inherent to these solutions will be structures to enhance spacecraft protection, by fracture along intended breakup planes, and re-entry demise characteristics. These structures will be subjected to functional tests as well as specific hypervelocity impact tests and material demise wind tunnel tests to demonstrate the capabilities of the 3D printed structures. At the same time, novel and complex technical, economic and legal issues of adapting the technologies to different vehicles, and implementing them widely across low Earth orbit will be tackled through the development of a hierarchical, web-based tool aimed at a variety of space actors. This will provide a complete debris mitigation analysis of a mission, using existing debris evolution models and lessons learned from theoretical and experimental work. It will output safe, scalable and cost-effective satellite and mission designs in response to operational
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Youth economic activity patterns in the perspective of changing socioeconomic institutions' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Based, on a comparative institutionalist approach, this study will analyse work-related trajectories of young individuals in the context of changing socio-economic patterns. Training content (objective, benefit and expected impact) The objective of this research is to improve my skills in longitudinal analysis, to enhance my knowledge of the relations of the impact of the different institutions on the labour market, and to develop a coherent comparative study methodology. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Electrocatalysis of greenhouse gases to fuels or chemical feedstocks on well-characterized materials' in the context of a Seventh Framework call.

assistant: **Objectives**

The project aims to generate a fundamental understanding of electrochemical processes that will enable the conversion of excess electrical energy produced by renewable sources to chemical energy, and store it in the form of fuels or useful chemical feedstocks. This can be realized by conversions of greenhouse gas molecules within the carbon- or nitrogen-cycle. The mechanisms of the reduction of such gases, as for example CO2 and NOx, are overall very complex and not well understood. The bottleneck in both cases is that our state-of-the-art understanding of the C-C or N-N bond-making reactions is not sufficiently developed. The reason for this lack of fundamental understanding is that the vast majority of research in the field has not been carried out on well-characterized surfaces, making the interpretation of experimental data very difficult. In this project, model surfaces will be utilized following a surface science approach, to obtain the necessary insights and breakthroughs related to the important C-C or N-N bond-making steps. This understanding is essential before considering any potential applications. This approach has been pioneered by the outgoing host group for fuel cell reactions and has established them as world-leaders in the field of electrocatalysis. This eminently successful approach will be used in this project as a basis for understanding the reactions of greenhouse gases. The strength of this project lies on the wide range of ex-situ and in-situ characterization methods that will be employed, in which the outgoing host has world-class expertise and facilities which are the best of the state of the art at an international level. The applicant will receive world-class training which will be a massive boost for his European career development. Moreover