RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The molecular foundation of cervical mucus plug protection from intrauterine infection during pregnancy' to be submitted under Horizon Europe.

assistant: **Abstract**

During pregnancy, the cervix undergoes dramatic remodelling characterised by the emergence of mucus secreting goblet cells (GCs) that generate a cervical mucus plug (CMP) in the cervical canal. The CMP is thought to act as a barrier that is crucial for maintaining uterine sterility, thereby protecting the foetus from ascending bacterial infections. However, this view is based on relatively little experimental evidence and our knowledge of specific endogenous or exogenous factors that may regulate cervical GC functions and CMP properties is virtually non-existent. This knowledge gap has significant clinical implications, as preterm birth is a common consequence of intrauterine bacterial infections and is associated with up to 0.6 million annual infant deaths.Over the previous decade, significant research efforts have been made to dissect GC and mucus protective functions in the gut and lungs, while the female reproductive tract has been largely neglected. Fortuitously, much of the knowledge and tools developed by this research can be repurposed to study cervical GCs and the CMP. These include transgenic mice with tagged cervical GCs, null mutant mouse models, targeted mucus biochemical and barrier property analytics, ex vivo mucosal methodologies and large-scale mutagenesis libraries of bacteria that can cause intrauterine infection.In this proposal we will repurpose these tools to: 1) Define GC and CMP gestational dynamics in pre-clinal mouse models; 2) Identify causal links between endogenous and exogenous factors that regulate GC and CMP functions; 3) Screen for bacterial virulence factors associated with breach of the CMP during pregnancy; 4) Isolate CMP alterations associated with human preterm birth. Addressing these aims will provide new insights into GC and mucus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Light Actuated Self-Pulsing Mircogels' to be submitted under Horizon 2020.

assistant: **Abstract**

Living organisms teach us how to design material structures that can move autonomously. Such motility is not restricted to animated organisms but can also originate from local differences t expansion coefficients in ligneous compounds. This challenges the design of micro-objects that can perform mechanical work and undergo locomotion. Irrespective of the specific material, three fundamental tasks must be solved: (i) to fuel the material for the actuation; (ii) to control the morphing of the object in time and space; and (iii) to establish a feed-back mechanism that enables timing of a sequence of steps. The later refers to an integrated clock function in order to pulse the energy input for distinct mechanical strokes. Within JELLYCLOCK, we address all three questions at the example of light driven hydrogel micro-objects. We have developed light sensitive microgels that change their shape within milliseconds. IR-irradiation of gold nanorods, entrapped in a thermosensitive hydrogel, is used to heat the gel from inside and enable a gradated spatial and temporal control of its swelling and shrinking. The water-based actuation will be directed to generate a non-reciprocal deformation as required for locomotion at low Reynolds numbers. So far, a directed cyclic deformation action relies on the outside modulation of the irradiation. We will extent this concept by introducing self-oscillating absorption efficiency, so that a stepwise body deformation becomes feasible under continuous irradiation. The project comprises (1) the advanced design of hydrogel based actuators driven by modulated light, (2) achievement of a precise control of the deformation in time and space , and as the actual disruptive step, (3) the realization of a self-sustaining pulsation under continuous near I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A computational design engine incorporating multi-disciplinary design and optimisation for blended wing body configuration'.

assistant: **Objectives**

The project will develop a multi-disciplinary computational design permitting teams, distributed across Europe to work together in creating optimised designs. The project uses the blended Wing Body configuration as a driving scenario to provide a challenging multi-disciplinary concept requiring a CDE to generate optimal designs. The project defines, specifies and implements an advanced CDE but progresses to a full design by first devising a prototype system. The engine will be able to coordinate structural aerodynamic, aero elastic and flight mechanics disciplines. Handling characteristics will be dealt with by incorporating appropriate models into two flight simulators at partner universities. STEP/EXPRESS interchange mechanisms and feature based modelling will be included in the system architecture, a system group and 8 universities from four EU nations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Production Flexibility and Efficiency through Simultaneous Three Axis Turning'.

assistant: **Innovation**

In manufacturing of industrial parts, turning is one of the most important manufacturing processes and is applied mainly by SMEs. However, until today, turning processes suffer from inflexible machine characteristics, as to mention an extreme high amount of needed tool holders and frequent tool changes caused by tool lives of > 3 minutes. In order to raise production flexibility and efficiency significantly, the proposed project FlexiSTAT is dedicated to enable the yet idle swivel axis (b-axis) in turn-/mill-centers and to integrate it as a third axis in turning operations. The consortium, assembling 11 partners from 6 EU Member States and Associated countries is well positioned along the entire value chain, including manufacturers of industrial parts, tooling and machine suppliers as well as specialized and thoroughly selected RTD performers.The overall project objective of developing a full technology package for Simultaneous Three Axis Turning will be realized by a threefold approach, combining the development of process planning, tooling-systems and machining strategies. These elements will be integrated modular into a technology package which can be easily adapted by almost all manufacturing SME, using their existing machine park. Especially SMEs will be the beneficiaries of the project results in terms of:- 30% production time and cost,- 80% tool-holders in stock,- 60% tool consumption.The exploitation of results of the project will increase the competitiveness of the manufacturing industry as well as of the technology providers. Due to the facts, that more than 35% of all cutting machines in SME industry are turning machines and that those SMEs are indispensable for e.g. automotive, energy technology, chemical industry, aviation, medical devices markets, the prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of damage-induced non coding RNA in the control of DNA damage response activation at telomeres in aging' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Genome instability is a hallmark of cellular and organismal aging. Cells evolved a prompt set of actions known as the DNA damage response (DDR) to preserve genome integrity. Until very recently, DDR pathways have been studied as networks of interacting proteins only. We discovered that the full activation of the DDR pathways depends also on long and short damage-induced non coding RNA synthesised from exposed DNA ends of DNA double-strand breaks (DSB). Inhibitory antisense oligonucleotides (ASO) targeting such non coding RNAs in a sequence-specific manner prevent DDR activation at individual genomic sites. Telomeres, the ends of linear chromosomes, are the best characterized genomic sites of preferential DDR activation during aging. Also telomere dysfunction, similarly to DSB, triggers the synthesis of non coding RNA and ASO against them prevent DDR activation at dysfunctional telomeres in cultured cells and in mice. We plan to determine the mechanisms that unleash ncRNA biogenesis upon telomere dysfunction and identify their mechanisms of action in DDR activation. By exploiting our unprecedented ability to inhibit DDR selectively at telomeres, we will determine the specific contribution of telomeric DDR activation to the detrimental phenotypes associated with aging-related disorders.


**Keywords:** Telomere,  DNA damage response,  Cellular senescence,  Phase transition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Managing Automated Vehicles Enhances Network' under Horizon 2020.

assistant: **Concept**

Highly automated vehicles and cooperative ITS technology will get more and more present in the near future. By combining both, guidance of (groups of) such vehicles can considerably improve especially in urban areas. For management of automated vehicles at signalized intersection and corridors, the MAVEN (Managing Automated Vehicles Enhances Network) project will develop infrastructure-assisted platoon organization and negotiation algorithms. These extend and connect vehicle systems for trajectory and maneuver planning and infrastructure systems for adaptive traffic light optimization. Traffic lights adapting their signal timing to facilitate the movement of organized platoons and reversely will yield substantial better utilization of infrastructure capacity, reduction of vehicle delay and reduction of emission. The MAVEN project will build a system prototype for both field tests and extensive modeling for impact assessment, contribute to the development of enabling technologies such as communication standards and high-precision maps, and develop ADAS techniques for inclusion of vulnerable road users. Additionally, MAVEN will include a user assessment and the development of a roadmap for the introduction of vehicle-road automation to support road authorities in understanding changes in their role and the tasks of traffic management systems. Finally, MAVEN will white paper on ‘management of automated vehicles in a smart city environment’ will be written to position the MAVEN results in the broader perspective of passenger transport in smart / future cities and to embed them with smart city principles and technologies as well as service delivery.


**Keywords:** Adaptive Traffic Light, Platoon Organization, Negotiation Algorithms, Trajectory and Manoeuvre Planning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Nano Scale Disruptive Silicon-Plasmonic Platform for Chip-to-Chip Interconnection'.

assistant: **Innovation**

The NAVOLCHI project explores, develops and demonstrates a novel nano-scale plasmonic chip-to-chip and system-in-package interconnection platform to overcome the bandwidth, foot-print and power consumption limitations of todays electrical and optical interconnect solutions. The technology exploits the ultra-compact dimensions and fast electronic interaction times offered by surface plasmon polaritons to build plasmonic transceivers with a few square-micron footprints and speeds only limited by the RC constants. Key elements developed in this project are monolithically integrated plasmonic lasers, modulators, amplifiers and detectors on a CMOS platform. The transceivers will be interconnected by free space and fiber connect schemes. The plasmonic transceiver concept aims at overcoming the challenges posed by the need for massive parallel interchip communications. Yet, it is more fundamental as the availability of cheap miniturized transmitters and detectors on a single chip will enable new applications in sensing, biomedical testing and many other fields where masses of lasers and detectors are need to e.g. analyze samples. Economically, the suggested technology is a viable approach for a massive monolithic integration of optoelectronic functions on Si substrates as it relies to the most part on the standardized processes offered by the silicon industry. In addition, the design and production cost of plasmonic devices are extremely low and with the dimension 100 times smaller over conventional devices they will require much lower energy to transfer data over short ranges of multi-processor cluster systems. The project is disruptive and challenging but it is clearly within the area of expertise of the consortium. It actually builds on the partners prior art such as demons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'THIN FILM AND NANO-STRUCTURED MATERIALS FOR PHOTOVOLTAÏCS' (1998-2002).

assistant: **Innovation**

The second generation of solar cells is based on thin film semiconductor (Si, GIGS, CdTe) materials and has the potential of comparable efficiencies to mono or multicrystalline silicon but at much lower cost. However, many issues related to material synthesis, defects at interlaces, stability and contacting are still under development and need more investigations. On the other hand, a new generation of cells based on nano-materials" like organics (molecules, polymers) or semiconductors (Quantum dots and wells) is emerging and it is growing strongly. The objectives of the "Thin Film and NanoStructured Materials for Photovoltaics symposia is to share at the same place the recent developments in both thin films and nostructures fields in terms of material synthesis and properties. In contrast to conferences devoted to photovoltaïcs which emphasis more on efficiency values, these symposia will focus on the growth issues, optical and electrical characteristics of the materials, carriers transport properties, cells manufacturing and finally the limiting factors of related efficiency, Presence of high level scientists in the different fields will allow to give an update of the last development but more importantly to present the perspectives.The "Thin Film and Nanostructured Materials for Photovoltaics symposia, planned for 2003 and 2005 , will be organized within the framework of the European Material Research Society (E-MRS) Spring meetings which bring about 1600 participants each year. The symposia THINC-PV are aimed to provide a forum meeting for scientists engaged in research and development of all thin films as well as on nano-structured based solar cells.The symposia will consist of invited presentations by leading scientists in their respective fields to highlight the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New electrochemical methods using sacrificial anodes for the synthesis of organic compounds' in the context of a Fourth Framework call.

assistant: **Objectives**

The main target of my work is the reductive electrochemical coupling of polychlorinated methanes and related compounds with alkylhalides and other electrophiles in the presence of a sacrificial anode (Mg, Al, Zn) and, if necessary, in the presence of a mediator or transition metal complexes as catalysts. Depending on the nature of the chlorinated compounds the research can be divided into three parts: Electrolysis of: a) gem-Dichloroalkanes b) Bromotrifluoromethane, Bromochlorodifluoromethane, Dibromodifluoromethane c) Trifluoromethyltoluene, Chlorodifluoromethyltoluene These compounds will be coupled with electrophiles like aldehydes, ketones, carbon dioxide, alkylhalides, DMF and alkanenitriles. The reactions are planned to be carried out in aprotic solvents in an undivided cell. These reactions can replace organometallic procedures and have several advantages, especially concerning industrial synthesis. Even organic halides which are not easily converted to the corresponding organometallic species (e.g. trifluoromethyltoluene) can be readilx carboxylated by electrolysis using a sacrificial anode. Especially the fluorinated compounds are usefill intermediates in the synthesis of pharmaceuticals and pesticides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Exascale Software Initiative 2\nTowards exascale roadmap implementation' (EESI2) under Seventh Framework.

assistant: **Objectives**

The use of High Performance Computing (HPC) is commonly recognized a key strategic element both in research and industry for an improvement of the understanding of complex phenomena. The constant growth of generated data - Big Data - and computing capabilities of extreme systems lead to a new generation of computers composed of millions of heterogeneous cores which will provide Exaflop performances in 2020. Such hardware architectures lead to outstanding technological breakthrough possibilities in computations but also to outstanding software challenges. In front of this challenge, the international community has launched various programs and organizations. In US this has been done through some funding programs such as the Ubiquitous High Performance Computing program and the co-design centre call. The International Exascale Software Project (IESP) had the goal to built a US and international roadmap. In Europe the EU PRACE project which is preparing the tier-0 level of the European HPC ecosystem, has been implemented. The successful first European Exascale Software Initiative (EESI1) federated the European community, built a preliminary European cartography, vision and roadmap and stated as the European voice at international level. However,  it is necessary to go one step  further towards implementation, by establishing a European structure to gather the European community,  by providing periodically cartography and roadmaps and dynamic  synthesis and recommendations in (i) defining and following up concrete impacts of R&D projects, (ii) detecting disruptive technologies (iii) addressing cross cutting issues in numerical processing and software engineering, (iiii) developing gap analysis methodology towards Exascale roadmap implementation. Overall, to achieve Exascale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Managing uncertainties in flood risk and climate change assessment: An exploratory study' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall aim of Man-U is to improve our understanding and management of uncertainties arising from the intersection of flood risk assessment and climate change projection with policy making. While the technical and scientific challenges involved in assessing the impacts of climate change on flood risks are enormous, if anything, the institutional challenges involved in using that science for policy making and the development of adaptation options are even greater. Man-U concentrates on this interplay of science and policy. It explores how first order scientific uncertainties about future flood risk are amplified by various institutional risks arising from the uncertainties of the policymaking process itself. In addressing the relationship between these dual challenges, Man-U is both scientifically innovative and policy relevant. Man-U takes a interdisciplinary perspective and explores (i) how flooding, the risks from climate change, and the uncertainties attributed to knowledge of them are framed, (ii) whether and how those framings are contested by different science and policy actors involved in flood risk assessment and (iii) with what implications for the development of adaptation actions and strategies. To explore these frames and conflicts, Man-U focuses on the particular case of England and conducts qualitative interviews with science and policy makers (n=60). Man-U will advance the state-of-the-art of understanding the institutional challenges of translating the scientific assessments of the impacts of climate change on flood risks into adaptation actions and strategies.