RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Comparing health services interventions for the prevention of HPV-related cancer' (COHEAHR).

assistant: **Concept**

Important progress has been made in the field of HPV-disease prevention with the development and implementation of HPV vaccines and HPV DNA screening. In the CoheaHr project, the (cost-) effectiveness of different European preventive strategies will be compared. The goal is to build a reliable and comparable evidence base on the (cost-) effectiveness of these policies implemented under country-specific preventive services conditions.To achieve this goal, a set of specific tasks will be carried out. Three randomized trials will be performed in organised screening settings to determine: i) whether self-collection of specimens for HPV DNA testing is an effective and feasible alternative for physician-based sampling, ii) whether screening intervals can be extended in women vaccinated at young age, iii) whether vaccinating women two years before entering the screening programme will favour the use of HPV screening. The first and third randomized trials are multi-country trials whereas the second trial will be carried out in a cohort of Finnish women vaccinated in 2007. For unvaccinated, 25-45 year old women participating in screening, acceptability and general feasibility of HPV vaccination will be studied in a multi-country demonstration survey. Comparisons by transmission models are included to provide long-term projections for cancer incidence and mortality. Furthermore, the establishment of a standardised joint European data warehouse will be continued and extended for (continuous) evaluation of comparative effectiveness of screening and vaccination policies in Europe. Finally, there will be an ongoing effort for producing systematic reviews and meta-analyses which provide a sustainable resource for evidence.CoheaHr will provide a strong evidence base which enable policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'POSITIVE-ENERGY BUILDINGS  THRU BETTER CONTROL DECISIONS' to be submitted under Seventh Framework.

assistant: **Abstract**

In the design and operation of positive-energy buildings a pragmatic target is maximization of the actual net energy produced (NEP) by intelligently shaping demand to perform generation-consumption matching. To achieve this, informed decisions in (almost) real-time are required to operate building subsystems and to account for unpredictable user-behavior, occupancy scheduling and occupants' activity and changing weather conditions. These decisions have direct consequences to occupant thermal comfort, energy efficiency and, ultimately, to the NEP. The complex interplay between the many parameters precludes empiricism or rule-based decisions and necessitates the development of generic decision tools.As maximization of the NEP for Positive-Energy Buildings is attained thru Better ControL dEcisions (PEBBLE), a control and optimization ICT methodology that combines model-based predictive control and cognitive-based adaptive optimization is proposed. There are three essential ingredients to the PEBBLE system: first, thermal simulation models, that are accurate representations of the building and its subsystems; second, sensors, actuators, and user interfaces to facilitate communication between the physical and simulation layers; and third, generic control and optimization tools that use the sensor inputs and the thermal models to take intelligent decisions. Building occupants have a dual sensor-actuator role in the PEBBLE framework: through user-interfaces humans act as sensors communicating their thermal comfort preferences to the PEBBLE system, and in return the PEBBLE system returns information with the goal of enhancing energy-awareness of the users. The generality of the proposed methodology affords a universality that transcends regional, behavioral, environmental or ot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthesis of mono-dithiolene molybdenum complexes and their evaluation as potential drugs for the treatment of human isolated sulfite oxidase deficiency' in the context of a Seventh Framework call.

assistant: **Objectives**

Two rare but usually fatal diseases are caused by a failure at different levels of the multistep biosynthetic generation of the three human molybdenum dependent enzymes involved in metabolic processes. In contrast to the more general Moco deficiency (MocoD) affecting all three enzymes, isolated sulfite oxidase deficiency (iSOD) cannot be treated yet. The proposed project is primarily aimed at synthesising a large variety of molybdenum complexes that mimic the natural molybdenum cofactor of the respective enzymes. These compounds will be prepared with a focus on distinct aspects of the biomolecules (first coordination sphere, different functional groups of the complex molybdopterin ligand, hydrogen bonding sites); their stability and ability to catalyse oxygen atom transfer (in particular the oxidation of sulfite) will be assessed and their suitability to bind in the active site pocket of the protein and restore activity will be tested. In addition alternative metals will be investigated with respect to possible benefits regarding stability and activity.The ultimate aim is to combine all the different synthetic approaches and information about properties to build a compound containing all indispensable functional groups while being stable, active and made with the least possible effort. Consequently this project addresses the human iSOD by developing synthetic structural models for the molybdenum cofactor active site of sulfite oxidase, testing their potential for incorporation into the biotechnologically generated apo-enzyme and evaluating the activity of the resulting semi-synthetic enzymes thereby assessing their suitability as future iSOD treatments. This work will have impact on the way iSOD and MocoD patients will be treated in the future and deepen the understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Apparatus for differentially counting Microorganisms' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of the cooperative research, for wich an exploratory award is here requested, will be to develop an apparatus for counting the microorganism possibly present in liquids, differentiating them in the more important pathogenic species. Main features of this apparatus will be its low cost, easy operating and the capability to give microbiological methods. This apparatus will be used in the microbiological control of water destined for human use, bathing, aquaculture and for monitoring food manufacturing and pharmaceutical and cosmetic products. The apparatus will be composed of 1) an electronic device to detect the physic-chemical modification due to the microbial metabolism occuring in the disposable reaction tube and a recording and printing device; 2) a disposable and sterelised reaction tube, containing the special reagent, to be filled with the sample. All steps of making the electronic device and the disposable reaction tubes will be covered by European SMEs active in electronics and electro-medical production. The apparatus is supposed to be utilised by private as well as official laboratories but in any case it can be handled by non-expert personnel in view of the simplicity of operation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Creation and application of novel symmetry surfaces'.

assistant: **Innovation**

POSITIONS AVAILABLE : The Surface Science Research Centre of the University of Liverpool is a world leading research centre in surface science with a research programme of the highest quality. Two Marie Curie Post-Doctoral Fellowships are available in the area of Creation and Application of Novel Symmetry Surfaces (CANSS). The positions are for 24 months each and the salary is at the EC recommended rate of approx. 2050 euro per month. The fellows will work with the groups of prof. R. Raval and Dr. R. McGrath on the creation, fictionalization and application of chiral surfaces and on characterization of clean and molecularly-modified quasicrystal surfaces. QUALIFICATIONS: Candidates must have a Ph.D. degree. We are seeking one candidate, to be appointed in late 2001. with experience in variable temperature scanning probe microscopy, and one candidate, to be appointed in 2002, with experience in STM theory and in theoretical interpretation of STM images. APPLICATION PROCEDURE: Candidates should send a current curriculum vitae and reprints of research papers to: Dr. Ronan McGrath, Surface Science Research Centre. The University of Liverpool, PO Box 147, Liverpool L69 3BX, UK. Tel. (44-151)7943873; Fax. (44-151)7080662. Informal enquiries may be made to by e-mail to r.mcgrath@liv.ac.uk. EThe University of Liverpool is an Equal Opportunities Employer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of Polycystic Kidney disease proteins in establishing and maintaining tubular structure' in the context of a Sixth Framework call.

assistant: **Objectives**

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common genetic diseases, affecting more than 12 million people worldwide. Two genes have been linked to the disease, PKD1, responsible for 85% of cases, and PKD2 for 15%.The genes are developmentally regulated and believed to play a key role in renal tubular differentiation. So little is known about the molecular aspects of the disease, including the function of the two gene products Polycystin-1 (PC-1) and 2 (PC-2), that no remedies have been identified to date. PKD causes 10% of all the renal transplantations in the world and in Europe.Only recently the function of the two proteins started to be unravelled. PC-1 is a 520kDa non-tyrosine kinase receptor involved in cell-cell/matrix interactions and in primary cilia function. PC-2 is a calcium channel most likely at the plasma membrane and in primary cilia. This Marie Curie Excellence Grant proposal seeks support for the implementation of a newly developed group based in Italy upon return of its team leader from the USA.The team leader was the first one to succeed in expression of full-length PC-1 and to generate a functional model for the protein. She now proposes to assemble an international excellence group to continue molecular studies on ADPKD using the invaluable tools generated as well as developing novel ones.The broad projects proposed include:- identification of a ligand for PC-1;- characterization of a polyproline sequence in the C-terminus of PC-1 and determination of its functional role within the context of the full-length molecule;- in vivo studies on the role of PC-1 in renal development and generation of animal models to better understand the disease.The team is part of the prestigious Dulbecco Telethon Institute (D TI), a virtual I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a Computational Code for the Design of Multi-Phase Processes at High Phase Fraction'.

assistant: **Objectives**

Objectives and content In a broad range of industrial sectors such as in chemical, pharmaceutical, food, oil, paint and biotechnology industries multi-phase processes are abundantly in use. These operations comprise gas-liquid, liquid-liquid or solid-liquid processes and often combinations of these classes are encountered. In the design and operation of these processes one often utilises scaling rules or correlations as the relevant physics is complicated and not well developed. This can be understood if one e.g. realises that lengthscales are involved of the order of metres (the impeller in a stirred tank) and also of one micrometer (e.g. the diameter of a droplet). Modelling of these processes requires capturing of this large lengthscale regime. In the last couple of years considerable progress has been made in the development of the physics related to the behaviour of the particles and its coupling to the flow of the fluid in process equipment. The methodology used is: Computational Fluid Dynamics, where the simulation of the flow and the consequence of the flow on the particle size distribution (and vice versa) has now become possible. This so-called two-phase CFD methodology has been applied successfully to processes such as emulsification and aeration provided the number of particles is relatively small. It is the objective of this project to extend this methodology to high phase fraction. This is extremely relevant as most industrial operations are executed in that regime for process-efficiency reasons. In order to be able to develop a robust and flexible simulation code for that regime, a number of fundamental problems have to be unravelled: droplet/bubble break-up and coalescence have to be modelled at high phase fraction, the CFD methodology has to be extended
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Strengthening and Sustaining the European Perspectives of Molecular Biotechnology in Lithuania'.

assistant: **Concept**

MoBiLi is a support action to strengthen the research capacities and to mobilize human resources in molecular biotechnology at the Institute of Biotechnology (IBT) Vilnius, Lithuania. Modern molecular biotechnology is a multidisciplinary research arena that integrates structural knowledge at different levels into cellular contexts to underpin biomedical questions. Such a multidisciplinary approach is crucial not only for our understanding of basic life processes but also is vital for characterizing the molecular basis of many diseases and the development of novel specifically tuned therapies and diagnostic tools. Lithuania strives to increase its RTD potential esp. in biotechnology but needs significant support to integrate into European Research Area (ERA). The purpose of the MoBiLi project is to build up scientific excellence and human potential of IBT thereby transforming it into an excellence centre in molecular biotechnology and a significant player in the ERA. The major objectives of the MoBiLi project are as follows: i) human capital building field of state-of-the-art molecular biotechnology; ii) networking of IBT with major centres of excellence in the EU; iii) upgrading and modernisation of research infrastructure in line with emerging thematic priorities in biomedical research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Six Senses of Science'.

assistant: **Innovation**

Science has always been enough of an inspiration for the Society to embrace it, invest in it, and utilize it. It is again the inspiration for us to embark on proposing the project under the Researchers’ Night 2013 call, after AWAREs – All We Are Researchers project I, II, and III. This project proposal is inspired by senses and engaging our senses in relating to the Science and the World in general.  The project proposal under the title Six Senses of Science (SoS ) is about turning on the senses and uniting energies in enhancing the public recognition of researchers, offering the public at large, regardless of their age and scientific background, the opportunity of discovering the ""human face"" of research. SoS project will show and prove the impact of research on our daily lives via direct exchanges and discussions with the researchers, who will help us better understand the scientific chain of cause-effect-result. The project will bring the researchers and public closer to one another, showing researchers’ usual activities and day-to-day work as well as hobbies, hopes and dreams.Bearing in mind that the senses make a basis of human perception, the main idea of the project is to offer multidisciplinary and innovative perception of the science, engaging all of the senses we are given at birth: sight, hearing, taste, smell, and touch. But, only some of us are endowed with one more special and yet controversial sense – the sixth sense! The extrasensory perception we also call a gut instinct, sometimes hunch. This being the inspiration for our project, we aim to present the researchers and research through the Six Senses of Science approach:Option 1Sense of Science #1: Smell the ScienceSense of Science #2: Hear about (ask and talk) scienceSense of Science #3: See the scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'U-Space Initial Services'.

assistant: **Objectives**

U-Space Initial Services project aims to demonstrate the technical and operational feasibility of providing in a very short time frame U-Space services to UAV/RPAS operators and to authorities focusing on:* UAV/RPAS/Pilot/Operator Registration Service* Flight Wish/Mission Notification & Authorization Service* U-Space NOTAM Service (including dynamic NOTAM for VLL)* UAV/RPAS Trafic Monitoring (including non-conformance vs regulation/authorized mission)The project combines the expertise of key stakeholders of the future U-Space (Civilian Aviation Authorities/Air National Service Provider, UAV/RPAS Operators, Industries and Law enforcement authorities) in order to insure that the services demonstrated fit for purpose to their requirements, constraints and needs. By bringing 4 Nations together, the consortium puts a particular focus on demonstrating services that can be deployed at a EU level.The consortium will consider any type of operations (from visual line of sight to very long range beyond visual line of sight) in all environments (from rural to urban).The demonstration will prove that U-Space services can be deployed in short time frame enabling safe, secure and efficient UAV/RPAS flight while contributing to their societal acceptance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Specific Support Action to establish a European Platform of Nursing Research' under Sixth Framework.

assistant: **Concept**

A Specific Support Action to establish a European Platform of Nursing Research" This proposal aims to enhance nursing research by identifying research programmes and potential for collaboration across Europe, within the context of multidisciplinary heal thcare practice. A Nursing Research Development Group (NRDG) will review nursing research, (meaning research on nursing issues or by nurses). The NRDG will develop a framework for programmes of research based on partnership between countries, concentratin g, initially, on EU countries where nursing research is most developed. This will provide a focus for international nursing research, increasing collaboration and enhancing capability for the delivery of nursing research. The SSA has four objectives: 1.m ap current research strategies, programmes and activities 2.map research capacity and capability building strategies 3.to identify areas where programmes of nursing research can be developed 4.develop an application for a Coordination Action for the call of October 2005, to establish a European Platform of Nursing Research."