RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Southern Ocean Overtuning Fingerprint Experiment' (SOFIE).

assistant: **Innovation**

The Southern Ocean overturning circulation exerts a powerful influence on Earth’s climate, and SOFIE is the first project seeking to detect and objectively measure the hydrographic fingerprint of changes in this overturning.The deep waters upwelling in the Southern Ocean account for up to half of the annual oceanic uptake of anthropogenic carbon from the atmosphere, dominate the global oceanic heat uptake with up to three quarters of the additional heat influx to the ocean occurring south of 30°S, and are a rich source of the nutrients that fertilise the majority of global ocean biological productivity north of 30°S.According to numerical studies, there is consensus that in response to increased westerly winds such as those occurring within contemporary climate change, variations in the overturning circulation are likely to be substantial.However, there is no established approach to provide observational evidence that these variations have occurred or are occurring in oceanographic measurements;and the lack of such an approach stems from the uncertain fingerprint of Southern Ocean overturning circulation changes on measurable oceanographic variables.Based on preliminary results supported by recent studies, SOFIE proposes that changes in the overturning circulation affect discernibly the ocean interior density structure from surface to depth across the Southern Ocean.We will rigorously test this hypothesis in the state-of-the-art numerical NEMO-OPA model, and assess in-situ evidence of overturning changes from the pan–Antarctic Argo network.To do this, SOFIE will combine model diagnostics of the Southern Ocean overturning circulation with the application to the model and in-situ fields of a novel algorithm characterising the vertical structure of the ocean.Given the ocea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Endosome positioning in tumour-stroma interactions' (EndoPos) under Horizon 2020.

assistant: **Objectives**

Endocytosis of cell surface receptors controls signaling during proliferation, differentiation and migration of cells, and plays a significant role in cancer progression. Invasive cancer cells accumulate recycling endosomes (including Rab11) at protrusions. This promotes the delivery of integrins, receptors for extracellular matrix, to regulate interactions between tumour cells and their surroundings, and coordinates actin polymerization through Rho family GTPases. The Rab11 family is particularly important in determining the aggressiveness of high-grade serous ovarian carcinoma (HGSOC). Despite its importance, the machinery that guides Rab11 trafficking and the functions of polarized trafficking are not clear in HGSOC. I aim to determine how recycling endosomes are positioned within HGSOC cells invading extracellular matrix, using BioID-based proteomics (a proximity labelling approach well established in the host lab) to identify the Rab11-associated machinery in HGSOC cells. I further aim to actively manipulate the dynamics of Rab11 positive endosomes in invading cells by developing a magnetogenetic approach to reposition endosomes in live cells, using a combination of my developed skills (including live imaging, protein engineering). Both cutting-edge methods will be applied in the most physiological and cancer relevant context to lend clinical relevance to our observations. Combining these innovative approaches will provide molecular detail and mechanistic insight to elucidate how localised endocytic trafficking controls tumour-stroma interactions in the metastatic niche and contributes to HGSOC lethality. This work will further provide targets for therapies aimed at suppressing metastasis and preventing relapse in HGSOC, a lethal form of ovarian cancer that has one
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of cholesterol in neurotransmitter receptor trafficking and synaptic plasticity' (SynaptoChol).

assistant: **Concept**

Synaptic connections in the brain are continuously remodeled in response to neuronal activity. This process, known as synaptic plasticity, is widely thought to underlie learning and memory, and to be altered in several cognitive disorders. An important aspect of synaptic plasticity is the regulated movement of neurotransmitter receptors in and out of the synaptic membrane.Cholesterol is an essential membrane component, and it plays a major role in membrane compartmentalization and trafficking. Although cholesterol only accounts for 2% of the body’s weight, the brain contains 25% of the body’s total cholesterol. The enrichment in cholesterol suggests a relevant role for this lipid in brain function. In fact, it, it is being increasingly recognized that cholesterol homeostasis have a role in neurological diseases. However, the precise role of lipids in neurotransmitter receptor trafficking is virtually unexplored. Here, we hypothesize that cholesterol plays a direct role in neurotransmitter receptor trafficking and therefore contributes to synaptic plasticity.To test this hypothesis, we are developing genetic tools to manipulate cholesterol levels in living neurons. We take advantage of the fact that neurons possess a unique strategy to metabolize the cholesterol originally provided by astrocytes, through the expression of the enzyme CYP46A1. To alter cholesterol content in a cell autonomous way, we will manipulate the levels of CYP46A1 exclusively in neurons. To evaluate the physiological consequences, electrophysiological recordings and cell biological studies will be performed in organotypic hippocampal slice cultures. Hence, this proposal involves the use of a multidisciplinary approach.We believe that this project will contribute to define the influence of cholestero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Atomically Precise Control of Strong Coupling In Molecular Dimers (SCIMER)' (SCIMER).

assistant: **Concept**

SCIMER aims to demonstrate strong dipole-dipole coupling of molecular dimers with a long-term goal of establishing rationally synthesized molecules as a reliable resource for quantum optics. Molecules embedded in crystalline matrices have long been used as bright single emitters beginning with the first observation of single molecule absorption by the Nobel laureate Prof. W. E. Moerner in 1989. Polycyclic aromatic hydrocarbons (PAH) have proven to be robust single photon sources with near unity quantum yield, lifetime-limited linewidths, and indefinite photostability in cryogenic conditions. Two of these PAH molecules then can coherently interact to create bimolecular quantum states that can emit two photons within short intervals with enhanced radiative rates. However, the major challenge in realizing strongly coupled PAH molecules has been locating suitable pairs of molecules within randomly doped matrices, leading to only two PAH molecules that have been shown to exhibit strong dipole-dipole coupling in the past two decades. In order to directly place molecules in spatial configurations suitable for strong coupling, rational synthesis of dimers connected with an inert chemical linker can be used to fix monomers in close proximity and specific orientations to each other with atomic precision. The rational synthesis of these dimers is a novel field that can make an impact in quantum optics, specifically in the development of strongly coupled dimers. With her background in optical spectroscopy and physical chemistry, the fellow is uniquely equipped to lead this interdisciplinary project. She will collaborate with organic chemists and perform advanced single molecule spectroscopy herself with support from the nano optics division at the Max Planck Institute for the Scien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Selective aptamer probe for detecting and targeting multimolecular G-quadriplexes aggregates in amyotrophic lateral sclerosis (ALS) disease', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

G-quadruplex structures (G4s) are gaining attention due to their widespread presence in the human genome, featuring over 700,000 identified sequences. These stable G4s are often found in critical areas of our DNA, such as telomeres, gene promoters, and regions linked to repeat expansions in diseases.However, when investigating their biological function, multimolecular G-quadruplexes (mG4s) have been often overlooked and deemed unlikely to be physiologically relevant, with the bulk of recent advances on G4-biology almost exclusively focused on unimolecular G-quadriplexes (uG4s).SPOTTER aims to fill this critical gap in the biology of mG4, by generating a selective probe that is currently missing to study these structures. Specifically, in this proposal, an aptamer-based probe that can be tuned to interact exclusively with mG4s will be developed.This tool will facilitate live-cell imaging and genome-wide mapping of mG4s for the very first time. This will further allow me to explore the role of mG4 formed in guanine-rich RNA repeat expansions, which could trigger formation of insoluble aggregates that are relevant to neurodegenerative diseases, such as in amyotrophic lateral sclerosis (ALS).


**Keywords:** Aptamers, G-quadruplexes, ALS, Chemical-Biology, Nucleic Acids, PEG
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DIgital comPEtitive next Generation Aviation technologies for SUStainable business models, products and services.' (Di-PEGASUS) under Horizon Europe.

assistant: **Objectives**

Di-PEGASUS overall objective is to enable fully autonomous cost-effective and environmentally friendly operations for seaplanes, VTOL and drones. This objective will be achieved by developing several enabling technologies targeting both the air and the ground side. In addition, Di-PEGASUS proposes to develop a digital platform to evaluate the viability of specific business models at particular locations, according to the digital technologies available, and the Key Performance Indicators (incl. cost-effectiveness, job creation, emissions savings, investment costs), in order to make recommendations to policy makers and relevant stakeholders that will host these services. This platform should also support the assessment of regulatory compliance to identify the safety assurance process that the technologies will need to follow, as well as the gaps in existing regulations that will need to be addressed.


**Keywords:** Urban Air Mobility, seaplanes, UAS, drones, impact assessment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Grain development in Brachypodium distachyon', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposal aims to exploit new molecular genomic resources for the small wild grass Brachypodium distachyon to understand the molecular basis of natural variation in grain morphology related traits that are believed to be locally or generally adaptive. I will complete a cellular and developmental characterisation of grain development in Brachypodium, characterise new accessions collected by collaborating groups from its native range (Israel, Spain and Turkey) for both morphological and genetic variation with the aim of relating morphological variation with its underlying genetic cause and its possible adaptive significance.The main objective over the next 3 years is to assess natural variation in key morphological characteristics of the grain in different accessions and define how this variation relates to geographic origin and population structure. These studies will provide new knowledge of the population structure and how plant architecture responds to the environment. I will also begin to establish the genetic lines required for QTL mapping and in the longer term identify the genes underlying the observed variation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new and innovative method to extract adipose Stromal Vascular Fraction: Application in post-prostatectomy erectile dysfunction' (MECADISTEM) under Horizon 2020.

assistant: **Objectives**

Erectile dysfunction (ED) is a significant and common medical problem which impairs quality of life of men and their partners. ED is a frequent complication after a radical prostatectomy (RP) due to surgical treatment for prostate cancer. For this condition, ED represents a significant unmet medical need, since there is no efficient treatment to repair the cellular damages following a RP. Clinical implementation of stem cell treatment represents a potential candidate for ED treatment after RP. Adult progenitor cells extracted from adipose tissue, called Stromal Vascular Fraction (SVF) have shown promising results in preclinical and clinical studies to treat post-RP ED. STEMCIS has developed a unique kit to isolate the adipose cells which hold the potential to cure post-prostatectomy ED by regenerating the damaged tissues. MECADISTEM comes in the form of a single-use kit that includes all the tools necessary to simply and rapidly (less than 30 minutes) extract adipose tissue progenitor cells mechanically (grinding, centrifugation, filtration). Compared to the state-of-the-art alternatives using “collagenase (enzymatic) digestion”, MECADISTEM does not require the use of enzymes, avoiding the problems and constraints imposed by the use of this enzymatic digestion and offering substantial time and money savings, on both technical and surgical operations. Having validated this methodology in preclinical study, this project is planned to finalise the development and market preparation of this kit. In this Phase 1 Feasibility Study, we aim to evaluate the main milestones of the project from a technical, commercial and financial point of view. Once in the market, MECADISTEM will be used by urologists and surgeons to cure ED in patients following a RP, where the current therapie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European electro-optic and nonlinear PIC platform based on lithium niobate' (ELENA), addressing dissemination and exploitation.

assistant: **Impact**

ELENA will develop the first European lithium niobate on insulator (LNOI) PIC platform, accessible to all interested entities in the form of an open foundry service. Lithium niobate (LiN) is one of the most promising emerging materials for PICs that comprises a unique set of interesting optical properties: a high electo-optic (EO) coefficient, a high intrinsic second-order nonlinearity, and a large transparency window. The focus of ELENA will be on developing 5 advanced photonic building blocks (BBs) which exploit the unique properties of LiN to enable novel functionalities in PIC (e.g. wavelength conversion and parametric gain) and to improve the existing ones (e.g. faster, more energy-efficient EO modulators). These BBs will be a part of comprehensive PDK library that will be accessible to entities outside of the consortium. ELENA’s approach will enable reliable monolithic integration of the LiN BBs to implement complex functionalities with better sensitivity, higher energy efficiency, faster speed and increased chip density. ELENA’s technologies will be applicable to a broad range of applications from telecom to LIDAR, quantum technologies and space. Moreover, ELENA’s ambition is to establish the key steps of a fully European supply chain to support the LiN platform. This include activities such as•Establish a process to produce 150mm optical grade LNOI wafers on an industrial scale•Develop a reliable and flexible packaging solution to interface LiN chips with optical fibers and other PIC platforms•Demonstrate the technology and validate the results by developing 4 PIC prototypes designed by 3 “end-user” partners covering fields of telecom, quantum technologies and microwave photonics  The ELENA project (42 months, €5M) with a consortium of 3 RTDs , 3 large industria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Governance and ethics of nanosciences and nanotechnologies'.

assistant: **Innovation**

The main objective of the project is to raise awareness of policy makers, experts, scientists, representatives of industry, third sector and general public in regard to the Commission’s Code of Conduct for responsible nanosciences and nanotechnologies research as well as other developments in governance and ethics of such research. It should also inspire further discussion on these subjects on national and European level, and encourage actions of the EU Member States concerning development of national regulations in the area of responsible nanosciences and nanotechnologies research.The above mentioned objectives will be achieved through organization of the Polish Presidency conference “Governance and ethics of nanosciences and nanotechnologies” (Nanoethics 2011), follow-up activities and the overall promotion of the project.The conference will be organized in Warsaw on 20-21 October 2011. It will have a particular focus on the EC Code of Conduct for responsible nanosciences and nanotechnologies research, and activities of Member States concerning implementation of the Code will be presented and discussed. Stakeholders opinions will be heard as well. The conference will also be an occasion to present other initiatives in the field of governance and ethics of N&N research, and will contibute to dissemination of the results of the EU funded projects in this area.The event is planned for 200 participants. Among them there will be: the EC representatives, policy makers from the EU Member States, scientists, experts, representatives of industry and CSOs, delegates of national academies of sciences, and representatives of media and general public.The event will result in elaboration of the conference proceedings and the post-conference report that will contain summary of the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Flooding Control and Standard for Stability and Crises Management' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The size of new passenger ships is continuously increasing. Bigger size offers bigger opportunities and economics of scale, but when a bigger ship accommodates more passengers there may be a higher risk, if evacuation is needed. Thus, new approaches have to be used and further developed in order to have the flooding under control if the watertight integrity of the ship is lost.  In the worst case, all flooding accidents may lead to the capsizing or sinking of the ship within a highly variable time frame.The need to ensure safe return to port or at least sufficient time for abandonment, will form major challenge in ship design. However, the assessment of the available time and the evacuation decision are not easy tasks. This process is complicated and there is a notable lack of data. Thus, guidelines and methods to tackle these problems must be developed. New tools are required in order to increase the designers' and operators' possibilities to reliably evaluate the ship's capability to survive in flooding accidents.This project sets to derive most of the missing data for validation of time-domain numerical tools for assessment of ship survivability and to develop a standard for a comprehensive measure of damaged ship stability, as a means of addressing systematically, rationally and effectively the risk of flooding.Unlike any current regulations the envisaged standard will reflect the stochastic nature of the damaged ship stability in waves. It will be based on first-principles modeling and thus it will reflect the nature of foundering as a process comprising loss of either (or both), flotation and stability, but also and more importantly ultimate loss of human life.Since risk-based, the standard will form a basis for decision support. It is expected that by explicit di