RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Distant early warning System' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The Distant Early Warning System (DEWS) proposal addresses the present major shortcomings and important societal problems related to early warning systems for tsunamis and other coastal hazards. DEWS will develop an innovative platform and services for the disaster management cycle between GITEWS hazard detection and warning/alarm. DEWS software will include models for tsunami wave spreading, assessment of vulnerabilities/consequences of natural disasters and systems for monitoring and crisis management, including information and decision support.Early warning distribution architectures will be developed, including systems for prompt local warning of citizens and managing efficiently tsunami hazards and natural disasters in general. The project will provide an important innovative research contribution and improve EU competitiveness in the crisis management area. DEWS will build on existing capacities, cooperate with other EU research and develop a platform and services, allowing for flexible practical implementation to meet different requirements in countries. DEWS will have interoperability with international cooperation mechanisms, including UNESCO-IOC, to ensure relevance and transferability of results to other tsunami-prone areas.DEWS will develop integrators for sensors and sensor networks, information logistics and dissemination modules, an early warning and warning distribution system, integrators for systems for local warning of the public, information and decision support products and a service bus. Testing will ensure future implementation and exploitation in different parts of the Indian Ocean Region. End-users will be involved in the development and testing to ensure the practical usefulness of the results. The consortium consists of large and small partner
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Post-Quantum Networks for Energy-eXfficient Transitions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cryptographic technologies and encrypted channel communications have become a standard security pre-requisite among government and industry protocols, schemes and infrastructure. Practical quantum computing, when available to cyber adversaries, will break the security of nearly all modern public-key cryptographic systems.Practical quantum computing, when available to cyber adversaries, will break the security of nearly all modern public-key cryptographic systems. Consequently, all secret symmetric keys and private asymmetric keys that are now protected using current public-key algorithms, as well as the information protected under those keys, will be subject to exposure. This includes all recorded communications and other stored information protected by those public-key algorithms, the so-called Harvest Now Decrypt Later (HNDL) paradigm. Any information still considered to be private or otherwise sensitive will be vulnerable to exposure and undetected modification. Once exploitation of Shor’s algorithm becomes practical, protecting stored keys and data will require re-encrypting them with a quantum-resistant algorithm and deleting or physically securing “old” copies (e.g., backups). Integrity and sources of information will become unreliable unless they are processed or encapsulated (e.g., re-signed or timestamped) using a mechanism that is not vulnerable to quantum computing-based attacks.PQ-NEXT will focus on developing a comprehensive framework to facilitate the seamless transition to post-quantum cryptographic standards. This includes creating a catalog of PQC algorithms, maintenance tools, and a quantum programming language with advanced features like high-performance simulation and hybrid quantum-classical optimization, ensuring crypto-agility and security against
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Savings and Risks Over the Lifecycle: Theory and Evidence'.

assistant: **Innovation**

People save for many reasons, such as to finance their retirement, to leave bequests to others, to start and develop a business, and to self-insure against risks. When young, these risks include wage risk, unemployment risk, entrepreneurial risk, and divorce risk. When old, one risks living to a very old age and running out of assets, being hit by expensive medical needs, and losing one’s spouse. An important factor affecting people’s risk exposure, and hence saving behaviour, is the public insurance provided by governments. Risks and insurance influence key economic choices and affect people’s welfare, macroeconomic aggregates, and inequality.The proposed research will develop and test models of individual and household saving to a) provide novel evidence on the determinants of saving at different ages; b) better quantify the interaction of saving with the insurance provided by the government and by one’s family; c) study how individual-level decisions affect macroeconomic conditions and the distribution of wealth; d) evaluate the effects of policy proposals and different institutions using quantitative model economies, calibrated to both the U.S. and European countries.The proposed applications include studying (i) the effects of means-tested public health insurance and its reforms on single retirees. (ii) A structural model of couples’ savings and risks in old age. (iii) Couples’ savings and labour supply during their whole life cycle, including the working stage. (iv) The effects of credit shocks on the saving and hiring of small-business owners and the resulting aggregates. (v) Differences in wealth accumulation between the healthy and the unhealthy.By better modeling and quantifying saving motives, risks, and publicly provided insurance, we can propose more effici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Retinal Gene Alteration in XLRP' (REGAIN).

assistant: **Innovation**

In this project the applicant proposes to develop a treatment strategy for a devastating blinding disorder affecting photoreceptor function within the first decade of life, X-linked Retinitis pigmentosa (XLRP). No treatment option exists to date.The proposed treatment strategy is based on the idea of inducing homology directed repair (HDR) of the mutation by promoting the exchange between the endogenous mutated chromosomal sequence and an exogenous repair DNA template at a double strand break (DSB) site in vivo. The treatment will be realized by co-delivery of endonucleases and the template DNA via adeno-associated virus (AAV) based gene transfer. However, This strategy has never been applied in the retina in vivo and therefore, several parameters are unknown, i.e. the average frequency of HDR in photoreceptors, whether DNA repair will take place through HDR or not, and the average length of the DNA conversion tract during HDR.The project includes the following parts: 1. Establishing the HDR frequency in photoreceptors in vivo: it is planned to optimize the frequency by co-delivery of trophic factors for the stimulation of the cellular repair machinery. 2. Inducing a bias of repair events towards HDR: it is planned to use nickases that only cut one DNA strand or will edit the expression profile of sensor proteins in the repair pathway in vitro and in vivo. 3. Optimization of the DNA conversion tract length: the expression profiles of helicases and other repair proteins are edited in vitro and in vivo. 4. Treatment of the PRGR2793delA mouse model: The optimized treatment settings are identified in order to test them for functional and morphological rescue effects.Results from this study will significantly advance the state of the art in targeted gene correction strategie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovating the Next-generation Specialized CBCT for Adaptive Proton thErapy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Proton radiotherapy has better healthy tissue sparing than conventional photon therapy due to protons' peaked depth-dose profile. However, the sensitivity of protons to anatomical and setup variations can result in delivery errors, potentially leading to tumor underdosage or healthy tissue overdosage. Online adaptive proton therapy (OAPT) improves delivery accuracy by daily adapting the treatment plan based on newly acquired images. Despite the well-established advantages and recent scientific advances through the H2020 MSCA International Training Network RAPTOR, OAPT has not yet become clinical practice, primarily because the quality of current onboard imaging is insufficient for proton dose calculation.This project aims to design the next-generation onboard cone-beam CT (CBCT) for proton therapy gantries to achieve sufficient image quality for proton dose calculation. Hardware upgrades for a current CBCT will be tested in silico by developing a Monte-Carlo (MC) simulation platform in Gate. First, the current CBCT will be modeled in collaboration with a manufacturer and the model will be validated experimentally. Then, an image reconstruction software will be implemented, using open-source libraries, which can be extended to support the hardware upgrades (e.g. reconstruction for dual-energy). Lastly, hardware upgrades will be simulated in the MC platform, including dual-energy CBCT, dynamic collimation, photon counting detectors and systems speeding up CBCT rotation to avoid motion artifacts. All upgrades will be evaluated with various virtual phantoms and evaluation will be performed in image space and dosimetrically.The project will show the dosimetric impact of these CBCT hardware upgrades, allowing the proton therapy community to understand the changes required to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Secretariat of the technology platform for the electricity networks of the future' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The European Technology Platform for Electricity Networks of the Future, also called SmartGrids ETP, began its work in 2005. It aims at fostering cooperation of major stakeholders in these fields through the design, update and implementation of a Strategic Research Agenda. In this context the Platform secretariat seeks to create strong links among stakeholders and R&D and Demonstration initiatives that contribute to the success of the “SET Plan – European Electricity Grids Initiative”, and to increase exchange of information among R&D and demonstration projects as a way to speed up the learning curve for smart grids technologies.The objective of this proposal is to provide continuity to the activities of the Platform with the support of an efficient and active secretariat, with flexibility needed to quickly react the challenges ahead, in terms of efficient, impartial and transparent management of platform activities, communication strategy and so contribute to achieving the statutory platform objectives and ensure their highest quality.The four main activity lines of the secretariat are:1. Support to the main bodies forming the internal structure of the Platform: definition and planning of its activities, organisation and management of meetings, and internal communication exchange.2. Coordinate and follow-up actions carried out by ETP groups or members , ensuring the generation of high quality outcomes and playing an active role in the development of key ETP public documents.3. Coordinate links with other related initiatives, providing the information and contacts to foster bi-directional exchange of information.4. Support in the definition and implementation of a communication strategy based around an information center (the public Smart Grids ETP internet site), confe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INdustrialised and PErsonalised Renovation for Sustainable sOcieties' (INPERSO).

assistant: **Innovation**

INPERSO is a holistic deep renovation programme addressing the building’s entire lifecycle and combining industrialisation and personalisation. The project will deliver inclusive, affordable, efficient, and sustainable renovation, adaptable to various climate zones and building typologies, but focused on residential and heritage buildings.Aiming to deliver a near-market solution, INPERSO is comprised of five highly exploitable, integrated results (IRs) plus an underlying, human-centric methodology for low-carbon renovation. New technological components leveraging the advantages of prefabrication, pre-integration and robotic 3D printing will drastically reduce the time (>50%) and costs (>25%) of construction, and increase resource efficiency, productivity and quality, coupled with waste reduction (>40%).The project highlights the advantages of digital solutions, by integrating scan-to-BIM, AI, AR and ML into the established RE Suite platform, creating a solid foundation for harmonising information flows and addressing the fragmentation challenges of the sector. These resources will also be used to optimise building energy performance and indoor environment quality, as well as improving the energy footprint of the renovation process, in addition to improving working conditions and safety.INPERSO will be demonstrated in Spain, Netherlands, and Greece, forming energy communities and promoting sustainable energy use. Ambitious upscaling and replication plans, supported by green financing and six business models, will be implemented to generate local and EU-wide impacts.The Consortium consists of 8 research organisations, 8 SMEs, 2 large enterprises and 3 NPOs, privately investing €4.7M in the project.


**Keywords:** Renovation packages
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Technology for improved manufacture of blades from environmental resources' (1994-1998) under Fourth Framework.

assistant: **Objectives**

PROJECT OBJECTIVES In order to stay competitive in the fabrication of rotor blades for wind turbines European manufacturers have to modify their current production technology and change their material choice. The current production process for rotor blades is very labour intensive, causing high production costs and long production cycles. To maintain the current price/performance ratio of a rotor blade the production process must change from labour intensive to capital intensive. This means mechanization and automation of the composites manufacturing process. An other important development is the ongoing upscaling of wind turbines and rotor blades, which causes logistic problems. Rotor blades nowadays have a length (up to 33 meters) giving rise to transport and assembly problems. By changing from single blade production to series production of smaller components, the logistical problems will be less emphatic. Especially when the components can be assembled locally at the wind turbine site. With the growing environmental concern in Europe an environmental friendly design of rotor blades will be of more importance. Beside the marketing advantages and recyclability, the use of alternative materials may offer great technical and economical advantages, e.g. reduction in weight and lowering of material costs. The alternative materials are of course also environmental friendly, e.g. less toxic, recyclable and renewable. The project therefore aims at the development of rotor blades and rotor blade components which use low-cost environmental friendly materials, and which in the long term can be produced with a mechanized and automated production technology. TECHNICAL APPROACH The following tasks are envisaged by the consortium (rotor blade manufacturer, research organisation, en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Drug adverse reactions predictability: exploring the mechanisms underlying the unexplained interindividual differences in drug metabolism and transport' under Seventh Framework.

assistant: **Concept**

Drug treatment is often inefficient. Only 30–60% of patients respond properly to treatment with e.g.  antidepressants, beta-blockers, statins and antipsychotics. Furthermore, adverse drug reactions (ADRs) frequently occur and cause about 7% of all hospital admissions, a frequency that is increased to 30% in elderly subjects above 70 years of age. This is due to a great extent to pharmacokinetics differences.Epigenetic modifications have been demonstrated to potentially participate in the regulation of ~60 human ADME genes. A correlation between the gene’s epigenetic state and possible influence on drug therapy outcome has been experimentally established only in relation to a few ADME genes.Several drugs with epigenetic actions are currently used or on clinical trials. The best examples are DNA Methyltransferases (DNMTs) and Histone Deacetylase (HDACs) inhibitors.In this project, we propose to elucidate the substantial unexplained fraction of interindividual variability in drug response and metabolism using a 3D multi-cell in vitro model of human liver in comparison to transcriptome and phenotype data obtained from a bank of 130 human livers with the following AIMS:AIM1: to unmask the epigenetically regulated ADME genesAIM2: to evaluate the epigenetically regulated ADME genes as interindividual variability biomarkersA list of epimarks of interindividual variation of drug ADME processes will be generated.AIM3: to test the epigenetic influence of candidate drugs. Our objective is to identify the specific ADME genes epigenetically altered by each drug treatment and elucidate the possibilities of interindividual variation in the ADME processes for each of the tested drugs.This approach is extensively multidisciplinary and multisectorial. The experimental design includes tiss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HIGH RESOLUTION LASER DOPPLER PERFUSION IMAGING IN DERMATOLOGY', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the evaluation and treatment of a number of diseases and conditions that affect the skin, there is a need for cost-effective, objective and reliable medical technologies. An example of such a technology is High Resolution Laser Doppler Perfusion Imaging (HR-LDPI), which, originally intended for visualisation of disturbances in micro-vascular blood perfusion in peripheral vascular disease, now makes possible the visualisation of tissue blood perfusion in terms of two-dimensional flow maps. The LDPI utilises a low power laser beam that scans the tissue surface, this gives an image of new and valuable information about the heterogeneity in tissue perfusion which is many situations has a significant diagnostic and prognostic value. Its non-invasive nature, in combination with ease of use and rapid response, makes this technology well suited for laboratory as well as clinical investigations of skin blood perfusion and dissemination to new applications, for which it was not originally intended. The most important of these new applications are found within the discipline of dermatology and may have a substantial impact on a variety of diverse fields including patch testing, screening for malignancies, multiple parameter assessment in association with cutaneous microdialysis and development of skin care products.The user needs within the four sub-projects listed above are not met by existing methods and procedures. Standardisation and harmonisation of the assessment and evaluation of various skin conditions and diseases are urgently required in order to meet these needs and to provide cost-effective and reliable alternatives to the procedures applied today.The project aimed at improving the diagnosis of common skin diseases that may impair the quality of life and even lead t