RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Seismic noise interferometry for stress analysis' (SIRENS).

assistant: **Concept**

As global warming accelerates, the need for effective solutions to reduce greenhouse gas emissions has become critical. Many of these solutions—such as geothermal energy, carbon capture and storage, and critical minerals for clean energy technologies—are found in the subsurface. The safe and sustainable use of these subsurface resources requires a precise understanding of the Earth’s stress field. Traditional methods for determining stress directions, particularly at reservoir and local scales, rely on costly and invasive borehole measurements.The SIRENS project offers a non-intrusive, cost-effective alternative by using passive seismic sensing to estimate the maximum horizontal stress direction (SHmax) at various spatial scales. This method capitalizes on the behaviour of rocks under compression, where crack closure is influenced by local stress conditions, with the fastest closure occurring in the direction of SHmax. By leveraging the ever-present seismic noise and Earth’s solid tides, it is possible to determine the SHmax direction.SIRENS will refine this technique, focusing on its application in the Iberian Peninsula. With its diverse tectonic landscape, extensive subsurface resources, and wealth of seismic data, Iberia serves as an ideal testing ground for advancing the methodology. The project will generate new insights into stress field estimation across different scales and provide a SHmax direction dataset that will contribute to Iberia’s energy transition.SIRENS is committed to open science by making its tools and datasets freely accessible to the public. Collaborating with academic institutions and industry will ensure that the project’s outcomes are tailored to the needs of key stakeholders. Moreover, SIRENS will pave the way for future innovations in divers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Stochastic Analysis, Mass Transportation and Free Probability' to be submitted under Seventh Framework.

assistant: **Abstract**

There are three different topics related to this project. The first one is an interplay between probability and Morse theory. The main idea is to exploit in the probabilitisc framework a suggestion of Witten and recover the Morse-Smale complex of a Morse function using asymptotics of Wiener functionals. The second topic is the study of transportation cost inequality on the path space of a Riemannian manifold and its connections with Log-Sobolev and HWI inequality of Otto-Villani. There were some attempts in the literature but it seems that the appropriate distance is yet to be settled. The third topic is in free probability. This regards first, second and higher order asymptotic freeness of Wigner ensembles and constant matrices. The results are to be applied to the study of random matrices with dependencies. Regarding functional inequalities in free probability, the standard tool is the random matrix approximation. The investigator used mass transportation thechiques to provide proofs of some of these inequalites in one dimensional free probability for measures on the line. Part of this proposal is an extension of these results to measures on the circle or in plane as well several noncommutative random variables.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Japan and EU Semiconductors: Mutual Innovation & Excellence' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

JASMINE (Japan and EU Semiconductors: Mutual Innovation & Excellence) is a Horizon Europe Coordination and Support Action (CSA) designed to strengthen strategic cooperation between the European Union and Japan in the semiconductor sector. In alignment with the European Chips Act, the project aims to enhance the resilience, sustainability, and competitiveness of the EU semiconductor ecosystem by leveraging Japan’s complementary strengths in materials science, manufacturing equipment, and advanced packaging.Over an 18-month period, JASMINE will conduct a comprehensive mapping of semiconductor value chains, identify joint research and innovation (R&I) priorities, and propose coordinated investment and regulatory strategies. The project will also foster talent development through staff exchange programs, job fairs, and academic-industry collaborations, while promoting alignment in Life Cycle Assessment (LCA) methodologies to support sustainable semiconductor manufacturing.By facilitating bilateral and multilateral partnerships, JASMINE seeks to deliver strategic recommendations and a roadmap for future EU-Japan collaboration, contributing to Europe’s goal of increasing its global semiconductor market share to 20% by 2030. The initiative brings together major leading institutions and companies across Europe and Japan, creating a robust framework for innovation, policy alignment, and long-term industrial cooperation.


**Keywords:** Semiconductor manufacturing, EU-Japan cooperation, Semiconductor value chain, Semiconductor sustainability, Strategic partnership, Life Cycle Assessment (LCA)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Translational Research and Innovation in Ophthalmology Vision - Centre of Excellence' (2021-2027).

assistant: **Innovation**

Eye diseases affect the daily lives of 2.2 billion people globally and have a significant socio-economic impact. However, recent advances have rapidly progressed our understanding of the mechanisms of ophthalmic diseases, opening unprecedented opportunities in the field of eye therapeutics. The development of new technologies (robotics, AI) and health services (virtual clinics) offers new solutions to improve the quality of life of ophthalmology patients and to reduce the costs and burdens for national healthcare systems. In the TRIO-VI project we address these challenges, focusing on translating the latest advances in science and technical research into practice in vision care. Together with strategic partners from UCL and Sorbonne, we create a centre of excellence – the International Center for Eye Research (ICTER CoE) in Warsaw, a sub-unit of the Institute of Physical Chemistry of the Polish Academy of Sciences. Unlocking scientific and translational potential of ICTER CoE guarantees tremendous impact on society, science, education and health by accelerating introduction of therapies and new solutions in vision care. It will boost the rapidly growing biophotonics and biomedical engineering industry in Poland by introducing new devices in ophthalmology.  As a result of TRIO-VI, we anticipate a considerable improvement in R&D&I capabilities in ICHF and ICTER, through enhanced education, training, and integrated skill development for all employee groups, with a focus on excellence, gender equality, and multidisciplinary collaboration. Thus, we aim to strengthen the R&I system in Poland, attract EU funding, increase visibility of Polish R&D institutions in EU and beyond, and substantially become a gamechanger for paradigm of ophthalmology in Central Europe. By boosting t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'European Reanalysis of the Global Climate System'.

assistant: **Concept**

Production of an extended climate reanalysis of the 20th century, with consistent descriptions of the global atmosphere, ocean, land-surface, cryosphere, and the carbon cycle. Production of a new reanalysis of the satellite era with near-real time data updates for climate monitoring. Research and development in various aspects of coupled data assimilation to improve the use of observations in future fully coupled earth-system reanalysis productions. Preparation of input data sets required for reanalysis, including uncertainty assessments, homogenisation, data reprocessing. Data rescue activities aimed at improving climate reanalysis capabilities, including imaging and digitisation of historic in-situ observations as well as recovery and assessment of early satellite data records. Development of data services and visualisation tools for reanalysis output products, and for the observations used to create them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breaking down barriers to foster new Cyclodextrin-based applications for healthcare by implementing sustainable design principles' (Bicyclos).

assistant: **Innovation**

Cyclodextrins (CD) have already gained several market applications as excipients in drug and vaccine formulations. They are very appealing platforms for the development of therapeutic applications and new CD-based systems are continuously proposed. In this frame easily prepared CD polymers frequently outstand the performance of the corresponding CD monomers. Nevertheless, application of new CDs as drug or delivery system in the clinics does not take off in spite of their most promising features. This is mainly due to a lack in transfer of knowledge between the academic world and the private sector focusing on CD for biomedical applications. The consortium formed by a multidisciplinary team, all with interest in CD and nanomedicines, accepts the challenge to bring CD-based systems closer to clinical application. To reach this goal an intense secondment scheme for young and experienced researchers is envisaged with activities that are all contributing to the scientific pursuit of CD progress. Activities focus on the design of sustainable syntheses of new CD, full characterization of new functionalized CD, the preparation of CD delivery systems for therapeutics and the study of the biological behavior of the CD-based nanomedicines in 2D and 3D models. The teams will embrace, already from the design stage, the production standards affording compliance with GMP for medicine development and prefer strategic approaches in line with the EU 2030 Agenda for Sustainable Development. The consortium features 11 partners with 4 coming from the private sector. Two of them hold concrete interest in the exploitation of research results as their core business focuses on CD for biomedical applications. This intersectoral and interdisciplinary team will foster new applications of CD-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Directions in Guaranteed Estimation of Nonlinear Dynamic Systems and Their Applications to Chemical Engineering Problems' (GuEst).

assistant: **Innovation**

The technique of guaranteed estimation promises a revolutionary step to how industrial process managers build, handle and adapt the prediction mathematical models. These are used to monitor the equipment operating regimes, to train the operating personnel and are also exploited to steer the plants' behavior towards the most profitable or the most resource-efficient modes. Advantages of guaranteed estimation come from the fact that no unnecessary assumptions must be made regarding the quality and measurement-error distribution of the sensed data, which establishes an increased reliability of theobtained estimation results. The work on this project develops the essential parts of guaranteed estimation techniques forreal-world exploitation. We focus on the estimation of parameters of the nonlinear dynamic models while combining theestimation with model validation principles and while creating a hybrid estimation technique that enjoys the advantages ofboth guaranteed estimation and conventional approaches. In order to drive the operation of the plant, here we focus on theplants of chemical industry, to an efficient working regime, the technology of optimal and robust control is required. Ourproject builds upon the developments of robust control and develops novel optimal robust control techniques that incorporatethe information on guaranteed estimates into the actions, i.e. manipulations of the plants' degrees of freedom. As a result, asafe, reliable and resource-efficient operation is established. The theoretical developments of the project are implementedinto a software package and released as an open-source project such that the collaboration with academia and industrialstakeholders is fostered. A demonstration on a pilot plant is also planned to showcase the benefits of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Placental Growth Factor (PlGF): new diagnostic and therapeutic applications in cardiovascular disease', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The proposed Strep evaluates the potential of PlGF as a pharmaceutical for major chronic progressive cardiac disorders (ischemic heart disease, heart failure and arterial insufficiency (intermittent claudication and critical limb ischemia)) and as a biomarker for cardiovascular disease. The proposed Strep is based on: 1) basic research on the VEGF-signaling pathway (via PlGF) performed over the last five years (CTG, VIB-3); 2) prototype research performed with recombinant PlGF for pro-angiogenesis (GT and TG); and 3) basic research on the association of plasma PlGF and VEGF levels and human diseases (IGB) and 4) the development of a diagnostic test to evaluate PlGF as a biomarker for cardiovascular disease. The comprehensive strategy encompasses the validation of the proof of concept" observations made by the academic parties of the consortium into therapeutic concepts in new relevant small animal models, development of industrial scale GLP/GMP quality materials and confirmation of their safety and efficacy in new, relevant large animal models. The strategy will be applied to the development of pro-angiogenic recombinant PlGF in ischemic heart disease models and in peripheral arterial insufficiency models. In parallel the value of PlGF as a predictive biomarker and as a diagnostic test for cardiovascular disease will be explored in a collaborative effort with a large diagnostic company. The principal aim of the project is to develop a new, safe and efficacious medicine to enhance the formation of blood vessels and in doing so, to develop new treatment paradigms for heart failure and limb ischemia."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'In situ structural biology of human immune defence', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Structural biology provides insights into protein function but generally requires purified complexes, which necessitates removing the protein from its native context. We therefore lose in situ information. Cryo-electron tomography (cryoET) provides this information, but finding a specific protein in a cell is akin to searching for a needle in a haystack 50 m tall. We are at the forefront of developing a technique to solve this problem; by combining super-resolution (SR) light microscopy on samples prepared for cryoET we can locate specific proteins and events within whole mammalian cells. This information can be correlated with 3D cryoET volumes to perform in situ structural biology. We call this technique super-resolution cryo-correlative light and electron microscopy (SRcryoCLEM). Here, I describe how we will enhance SRcryoCLEM and use it to image antibody-activated aspects of human immunity, enabling the development of cutting-edge immunotherapeutics. The first aim of this proposal is to augment SRcryoCLEM with multicolour imaging and automated data analysis. Spectrally-distinct fluorescent proteins will be identified that are ideal for cryoSR imaging, and AI-based volume segmentation and automated particle picking will help to democratise in situ structural biology. The second aim is to deliver in situ structural data to explain discrepancies in antibody effector functions with an unknown structural cause, which will be used to perform structure guided antibody design to further enhance their effector functions for the benefit of human health.The third aim is to discover the structural determinants orchestrating antibody-mediated phagocytosis by macrophages using SRcryoCLEM. This immunologically-pivotal mechanism is poorly understood, but is being exploited as a nex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Building a European identity' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content It is reasonable to think that the more Europe is perceived as a meaningful entity, the more people are likely to identify with it. We translated this common sense opinion into a precise hypothesis testable by means of an experimental methodology. We assumed the perception of the meaningfulness of Europe to be a function of the perception of its internal coherence and of its distinctiveness with respect to non-European countries. In turn, - and as our researches already demonstrated - these two processes are a function of the social comparison activity individuals are engaged in during their everyday life. We plan to conduct a series of experiments in which these factors will be controlled with the alm of isolating those conditions propitious to a stronger identification to Europe. In line with the numerous demonstrations in the field of social influence attitude change, minority power and the like, the ultimate goal is to show that once people define Europe as a prominent and socially significant in-group their behavior is likely to be shaped by group's (European) norms of conduct. Training content (objective, benefit and expected impact) By performing this research project, the applicant will deepen his knowledge in the domain of inter-group processes as well as his practice with experimental methodology (resulting in a PhD dissertation). At the same time, the training will ensure him the development of a specific competence on European identity concerns.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PeRsistent Infection of Shigella in Macrophages (PRISM): Shedding light on the intra-phagocytic lifestyle of Shigella sonnei using human induced pluripotent stem cell-derived macrophages' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Shigella is a human-adapted invasive pathogen and a high-priority antimicrobial resistance (AMR) threat, responsible for up to 165 million cases of bacillary dysentery and over 200,000 deaths annually. Emerging evidence shows that certain lineages of Shigella, including Shigella sonnei, can establish long-term infections in patients and animal models. Persistent infections are a significant public health threat, as they can cause recurrent disease manifestations. Persistent infections also complicate diagnosis, encourage transmission, and reduce the effectiveness of antibiotic treatments, promoting the emergence of AMR. My findings reveal that S. sonnei can survive within human macrophages, challenging the long-standing view that Shigella invariably induces rapid macrophage death. The S. sonnei O-antigen, a surface polysaccharide, contributes significantly to the establishment of persistent infections; however, the exact mechanisms by which S. sonnei persists remain unknown. Using infections of human-induced pluripotent stem cell-derived macrophages, I aim to (i) characterise the S. sonnei intra-macrophage persistent infection niche (I will identify where and how S. sonnei survives inside macrophages, and which host pathways are altered during long-term infection); and (ii) dissect the role of the O-antigen in promoting persistent infection (I will determine how the O-antigen affects bacterial survival in host macrophages and how it contributes to immune evasion). To meet these objectives, I will adopt a multidisciplinary approach, involving stem cell technologies, advanced imaging techniques, state-of-the-art gene expression profiling, gene knockout-based screenings, and targeted modification of bacterial surface polysaccharides. This project will deliver the first cha