RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cellular and circuit determinants of dendritic computation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

What is the fundamental unit of computation in the brain? Answering this question is crucial not only for understanding how the brain works, but also for building accurate models of brain function, which require abstraction based on identification of the essential elements for carrying out computations relevant to behaviour. We will directly test the possibility that single dendritic branches may act as individual computational units during behaviour, challenging the classical view that the neuron is the fundamental unit of computation. We will address this question using a combination of electrophysiological, anatomical, imaging, molecular, and modeling approaches to probe dendritic integration in pyramidal cells and Purkinje cells in mouse cortex and cerebellum. We will define the computational rules for integration of synaptic input in dendrites by examining the responses to different spatiotemporal patterns of excitatory and inhibitory inputs. We will use computational modeling to extract simple rules describing dendritic integration that captures the essence of the computation. Next, we will determine how these rules are engaged by patterns of sensory stimulation in vivo, by using various strategies to map the spatiotemporal patterns of synaptic inputs to dendrites. To understand how physiological patterns of activity in the circuit engage these dendritic computations, we will use anatomical approaches to map the wiring diagram of synaptic inputs to individual dendrites. Finally, we will manipulate dendritic function using molecular tools, in order to provide causal links between specific dendritic computations and sensory processing. These experiments will provide us with deeper insights into how single neurons act as computing devices, and how fundamental computa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Networking Activities for Nanotechnology-Facilitated Cancer Theranostics' (NANOFACTS), addressing dissemination and exploitation.

assistant: **Impact**

The main goal of NANOFACTS is to efficiently overcome the networking gaps and deficiencies in research capabilities and collaboration regarding research in cancer theranostics nanomaterials and biosensing diagnostics of cancer, between BIOS and the partner institutions, internationally-leading counterparts at EU level, leading to the enhanced scientific andtechnological (S&T) capacity of all the participating institutions with a principal focus on BIOS. In order to widen the research agenda at BIOS with cancer-related research and health-related biosensing technologies, NANOFACTS will harness and improve pre-existing links with two leading European research institutions in the field of nanotechnology and development of biosensors:• Trinity College Dublin (TCD), Ireland, The School of Pharmacy and Pharmaceutical Sciences, an expert in application of nanotechnology for cancer treatment and imaging; and its validation, including biocompatibility of nanoparticles/nanodevices.• Vienna University of Technology (TUW), Faculty of Technical Chemistry, Institute of Applied Synthetic Chemistryand Institute of Chemical Technologies and Analytics, an expert in devising health-related biosensors.The main strategies to be explored during the project activities will include:a) BIOS researchers gaining knowledge on devising theranostic nanoparticles for real-time in vivo detection of cancer biomarkers, along with simultaneous targeted cancer therapy and imaging and b) enhancing the capacity of biosensing technologies at BIOS with cancer-related biosensing, including construction of an array of user-friendly personalized point of-care microfluidic and electronic diagnostic devices for electronic and optical sensing of cancer biomarkers, which could be introduced to home disease-monitorin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of (a/v)tlxt(t/s) sequence in the regulation of l-amino acid decarboxylases' in the context of a Fourth Framework call.

assistant: **Objectives**

Polyamines play an essential role in cell growth and differentiation, and their biosynthesis pathway may be an important target for design of chemotherapeutic agents. Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in polyamine biosynthesis. ODC is a highly regulated enzyme with contro] points at the level of transcription, translation and protein degradation. Indeed, ectopic expression of ODC conferred a transformed phenotype to mouse fibroblast. These results suggest that modulation of ODC activity is important for growth regulation. Recently a consensus sequence, (AIV)TLXT(T/S), has been identified which is present in all mammalian L-amino acid decarboxylases that are regulated by polyamines, has been detected. The objective of the proposed project is to characterize the role of this sequence in the regulation of ODC expression and activity. Transfection of cells with different ODC construct carrying specific mutations of this sequence will be use. The results of these studies will be extended to other selected L-amino acid decarboxylases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Roles of astrocytes in synaptic transmission and plasticity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The research area of this proposal is Life Science at the intersection of neuroscience, pharmacology and physiology. In the central nervous system (CNS), astrocytes are both numerous and complex. They contact most other cell types in the CNS, and the processes of a single astrocyte can envelop as many as 140,000 synapses. Thus, these cells are uniquely able to receive signals from many sources, in particular synapses,  via their G protein-coupled receptors (GPCRs). Additionally, using conventional pharmacological approaches, it has suggested that astrocytes can also send signals to neurons by release of various transmitters to modulate synaptic transmission and plasticity. This reciprocal signaling between neurons and astrocytes (gliotransmission) is still a novel concept, and its physiological relevance remains controversial in the field. In the first part of this proposal, we propose to use novel pharmacogenetic tools that will allow us to selectively activate astrocytes vs. neurons in a more physiological manner to further test the concept of gliotransmission and its role in sleep and memory in vivo. In the second part of this proposal, we will take advantage of these powerful pharmacogenetic tools to test a hypothesis that has heretofore been inaccessible to experimentation, i.e., the possibility that astrocyte GPCRs control glycogen metabolism to modulate synaptic transmission, plasticity, sleep and memory formation. Addressing successfully such major questions in the field of neuroscience, and in particular, resolving some controversies about gliotransmission has profound implications in our understanding of the brain, but also and importantly ,in the clinic. From these studies, we are likely to resolve important aspects of astrocyte function and open up entirely
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Market Design and Participation:  Comprehensive Design for Matching Markets'.

assistant: **Innovation**

Market Design combines theoretical and empirical methods to design, analyze, and enhance real-world assignment markets. Many of these markets involve limited or no monetary transfers: civil servants (e.g., teachers), daycare placement for children, organ allocation for patients and so on. These markets often interact with external opportunities or themselves over time. For example, a patient in need of a kidney may have multiple treatment options, families must choose from various childcare alternatives, or public school teachers may request multiple transfers throughout their careers. However, we have a limited knowledge about how these multiple opportunities interact with the assignment procedure. Incorporating such options into the design of these markets is challenging due to data limitations as well as the complexity of the models.The MADPART project aims to address these challenges by understanding and improving the design of assignment markets in the presence of outside options. It has two primary objectives: 1) Investigating how outside options discourage market participation and undermine policy objectives, specifically exploring how participation-blind procedures contribute to these losses. 2) Identifying novel and innovative designs that enhance the functioning of these markets. This will be achieved through the combination of advanced theoretical models and cutting-edge empirical methods. The project will leverage unique and novel datasets from four assignment markets: the allocation of public school teachers to schools, children to public daycares, kidneys to patients, and social housing allocation. These markets exhibit dynamic interactions with external options.The outcomes of the project will give a more comprehensive and deeper understanding of assignme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Clothing, fashion and nation building in the Land of Israel' (IDCLOTHING) targeting Horizon 2020.

assistant: **Abstract**

Culture is central to nation building, but clothing, fashion and aesthetic perceptions are often overlooked in this context. Taking ""Eretz Israel"" (the ""Land of Israel"") as a case study, this project argues that investigating these cultural practices brings to the fore the agency of migrant groups and adds a personal dimension to the history of nation building. Focusing on the period from the 1880s when large-scale migration began, until the foundation of the Israeli state in 1948, it investigates how Eastern European and German Jewish immigrants expressed social, cultural and political belonging through clothing and to what extent they were able to enforce their ideologies in the course of nation building. It asks to what extent the immigrants influenced each other in developing a specific mode of dress, and how they referenced the socio-cultural and political practices of countries of origin, as well as the clothing of Arab people and the Ottoman and British occupying authorities. With an unprecedented focus on gender and visual materials, the project examines how clothing became fashion and to what extent a consensual mode of dress emerged within a heterogeneous migrant society. Drawing from archival collections of 15 archives in Israel, Poland and England, and 6 Israeli, German, American and Russian databases, the project analyses private and public photographs and posters, and contextualises them against an assessment of written material and oral history interviews. Through highly interdisciplinary training, the project develops a new methodology that integrates approaches from fashion history and visual culture into the history of nation building to shed light on the processes of negotiation and power struggles on the micro level of a community. In times of ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Undeserving of the Union: The American Idea of the 'Underclass' in Europe, 1992-2011' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The aim of this project is to write a cultural history of the different ways in which the American construct of the ‘underclass’ was exported to different European national contexts in the twenty years following the Maastricht Treaty. Through a web of transatlantic relations, the concept was modified and adapted to those segments of the population that were hit the hardest by the ongoing processes of deindustrialisation, thus impacting the way in which Europeans problematized poverty and marginalisation. Academic writing, journalism and politicians’ speeches became the vectors of a gradual change that involved public policy at all levels, as well as national common sense. The project aims at verifying the hypothesis that the importation and adaptation of the concept of ‘underclass’ was functional to the differentiated implementation of neoliberal policies in different but interrelated contexts. It focuses such exploration on Italy, Germany and the United Kingdom. The choice of making it as cultural history is based on the premise that the magnitude of this shift in policy and mentality can only be gauged through an interdisciplinary methodology integrating analytic tools from history, sociology and cultural studies. Thus, as a scholar of literature and culture, I have chosen as my prospective supervisors two sociologists. Should my application be successful, I would be working with Professor Fabio Perocco at the Ca’ Foscari University of Venice, who has long worked on the comparative sociology of inequality, and with Professor Loïc Wacquant at the University of California, Berkeley, whose symbolic-sociological analysis of various aspects of neoliberalism has informed much of the theoretical frame of this project, and who has done extensive work on the history of the con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CO2 ROUTES ACROSS EUROPE' (COREU), addressing dissemination and exploitation.

assistant: **Impact**

COREu will demonstrate key enabling technologies in a CCS value chain and support the development of three new CCS routes in Central-East Europe (CEE), helping accelerate CCS development . COREu will (a) provide the means for development of an open-access, trans-national network (infrastructure and logistic) to connect emitters with storage sites in Europe, by identifying multimodal transport requirements, and developing emitters’ clusters to create the demand and the investment rationale, (b) increase the knowledge of the CCS value chain across Europe through interconnected initiatives, sharing of experience, knowledge and data to create a common framework that encompasses all key aspects of CCS deployment: technological know-how, business models, consensus management, monitoring, reporting and validation, policy framework, transport and storage safety. COREU will contribute to 6.8Mt/year in CO2 reduction by 2035 and 36Mt/year by 2050, develop 8 innovations for Measurement Monitoring Verification, interoperability and Value Chain Monitoring, and improve the Internal Rate of Return of CO2 infrastructure investment by 6% through de-risking core technologies.


**Keywords:** Demonstrations, CCS value chain, CO2 impurities, Multi-modal transportation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trees, agroforestry and climate change in dryland africa' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

a) Selection of participants and speakers for first Workshop in Mali (Apr 02);b) Workshop report & formation of teams for model evaluation (Jul 02);c) Complete parameter libraries for tree, crop, soil and socio-economic data (Dec 02);d) Report on modelling results and user-support (Jul 03);e) Final workshop to agree book drafts, research recommendations and climate change mitigation strategies (Sept 2003);f) Completion of book and final report (Dec 03).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A combined experimental and computational approach for high-throughput protein determination in the genomic era biology' under Sixth Framework.

assistant: **Concept**

Over the last years, genome-sequencing projects have provided new information about genes. While all these data have proven very useful to understand and exploit the information encoded in a genome, the knowledge of the 3D structures, functions and interactions of the coded proteins is required in order to integrate all this information in relevant areas such as drug design.The wealth of genomic sequence information opens the way for a systematic program of high-throughput structure determination, driven mainly by the idea of producing a representative set of protein folds that could be used as templates for comparative modelling purposes.Within their frameworks of structural genomics projects, X-ray crystallography and NMR techniques are used to provide high-resolution protein structures at large scale. Despite the advantages and developments in X-ray crystallography and NMR, the structural and functional assignment for the large number of known protein sequences remains a pressing problem for the genomic era of biology.Computational structure prediction methods can provide valuable information for the fraction of sequences whose structures cannot be determined experimentally. The recognition of a protein fold provides valuable information about its function. While many sequence-based homology prediction methods exist, an important challenge remains: two highly dissimilar sequences can have similar folds.How can this be quickly detected in the context of structural genomics? High-throughput NMR experiment s coupled with novel computational algorithms can address this challenge. The main idea here is based on protein 'fold recognition' using 15N-1H RDCs, together with sequence information, as query on a fold library of solved structures. For the matches found, more accu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Communicating urban growth and green: assessment of planning concepts and policy instruments for sustainable development of the urban landscape' (GREENSCOM) under Fifth Framework.

assistant: **Objectives**

Problems to be solvedMost cities in Europe are facing the challenge to make urban green an integral part of urban growth. Steering towards a balance between urban expansion and the quality of green areas requires good governance and is sometimes highly problematic. If growth takes the form of expansion in the urban fringe, there is increased pressure of sub-urbanisation, urban sprawl and traffic on surrounding greenbelts. If there is growth in the existing city, there is the pressure of intensive use, building activities, fragmentation by roads, pollution and noise imposed on green areas and other open spaces in existing cities. In some of these open spaces, the so-called 'brownfields', pollution inherited from past industrial uses may pose difficulties to conversion for either housing or green functions. As a result there is increased pressure on the 'greenfields' in the urban fringe. In many cases, green areas become small and scattered, polluted and disturbed. Traditionally, urban growth and green are seen as competitive or even mutually exclusive. Yet cities have sometimes found ways to turn 'green fingers' or 'greenways' into the backbones of urban development. Policies and projects have been launched aiming at both sustainable economic and ecological development. The GREENSCOM project focuses on learning from success and failure of local government experiences in this context.Scientific objectives and approach:Abundant technical knowledge is available on green structures and urban open spaces, but the 'process-knowledge' of communication strategies and policy instruments often remains under explored. Learning about these aspects of governance is the central research objective of GREENSCOM. The project consists of a series of working packages that will each have a