RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Phosphorus REcovery for FertiLisers frOm dairy processing Waste'.

assistant: **Innovation**

REFLOW is an interdisciplinary cross-sectoral European Training Network combining world-leading scientists and key stake-holders in dairy processing, fertilizer production and phosphorous recycling with early stage researchers to address important technical and socio-economic challenges associated with the recovery of phosphorous from dairy processing waste water and its recycling into fertilizer products enabling sustainable expansion of the dairy industry in Europe. REFLOW research will (i) mitigate the environmental impact of dairy processing waste on soil and water, (ii) provide safe environmentally sustainable, cost effective closed loop solutions for crop nutrient management (iii) meet the demand for skilled professionals to support the technical, regulatory and commercial development of the market for recycled phosphorous fertilizer products in accordance with the deliverables of the Circular Economy Package. REFLOW will achieve these goals by creating an innovative and entrepreneurial training environment for the next generation of scientists. 13 ESRs will be recruited in a network of 10 beneficiaries and 14 partner organisations who bring complementary expertise and experience of delivering technical solutions, socio-economic modeling, environmental analysis, policy frameworks, high level training and commercial entrepreneurship. Graduating fellows will be equipped with a unique range of relevant interdisciplinary and cross-sectoral skills for careers as independent industrial or academic researchers, entrepreneurs, regulators or agri-environmental specialists. REFLOW will train the Fellows through an integrated and cohesive curriculum of network-wide partner training activities including industrial secondments and embedded commercially driven research projects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Embodied Minds and Mentalised Bodies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

How does our acting, sensing and feeling body shape our mind? The mechanisms by which bodily signals are integrated and re-represented in the brain, as well as the relation between these processes and body awareness remain unknown. To this date, neuropsychological disorders of body awareness represent an indispensible window of insight into phenomenally rich states of body unawareness. Unfortunately, only few experimental studies have been conducted in these disorders. The BODILY SELF will aim to apply methods from cognitive neuroscience to experimental and neuroimaging studies in healthy volunteers, as well as in patients with neuropsychological disorders of body awareness.  A first subproject will assess which combination of deficits in sensorimotor afferent and efferent signals leads to unawareness. The second subproject will attempt to use experimental, psychophysical interventions to treat unawareness and measure the corresponding, dynamic changes in the brain. The third subproject will assess how some bodily signals and their integration is influenced by social mechanisms.  The planned studies surpass the existing state-of-the-art in the relevant fields in five ground-breaking ways, ultimately allowing us to (1) acquire an unprecedented ‘on-line’ experimental ‘handle’ over dynamic changes in body awareness; (2) restore awareness and improve health outcomes (3) understand the brain’s potential for reorganisation and plasticity in relation to higher-order processes such as awareness; (4) understand how our own body experience is modulated by our interactions and relations with others; (5) address in a genuinely interdisciplinary manner some of the oldest questions in psychology, philosophy and medicine; how embodiment influences the mind, how others influence the se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interactions between marine algae and bacteria' in the context of a Seventh Framework call.

assistant: **Objectives**

Trophic interactions between bacteria and unicellular algae in aquatic systems are well documented in the literature as the microbial loop plays a critical role in important processes as carbon flux and nutrient regeneration. In contrast, chemical interactions between bacteria and harmful phytoplankton and their potential impact on the production of biotoxins and population dynamics have received comparatively little attention.  The scientific goal is to identify specific mechanisms of action involving allelochemicals in bacterial-algal interactions and their role in harmful algal bloom (HAB) ecology. The overall objective of the project is to explore whether or not HAB species can selectively promote the growth of bacteria, through the production of allelochemicals that may inhibit the killing of algicidal strains.  The project aims to determine 1) the antibiotic properties of allelochemicals using model algal-bacterial communities 2) whether bacteria affect gene expression and the production of allelochemicals, 3) whether bacteria sensitive to allelochemicals produce algicidal compounds, and 4) the nature of poorly characterized allelochemicals. Natural plankton communities and selected phytoplankton and bacteria cultures will be studied using a multidisciplinary approach i.e. physiological, chemical and molecular-based techniques. The project will contribute to enhance technological, scientific and professional skills of the applicant and facilitate the reintegration of full time research and the possibility to attain a professorship over a short time period.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeting tubular reabsorption for kidney protection', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Many forms of chronic kidney disease are featured by the loss of protein into the urine (proteinuria). When the cause of proteinuria lies within the glomerulus, such as in diabetic kidney disease, then the protein overload in the tubular lumen may lead to damage of the downstream tubular cells. Particularly vulnerable are proximal tubular cells (PTCs), because these cells are specialized in protein reabsorption and have a high metabolic demand. Dysfunction of the main albumin uptake receptor cubilin (encoded by the CUBN gene) leads to the reduction of albumin uptake and albuminuria. Here, we hypothesize that genetic variants in CUBN are key for providing a cell-to-cell variability that is beneficial for PTC homeostasis and resistance against proteinuric kidney disease. This hypothesis is based on our recent findings that 1.) CUBN mutations are well tolerated by humans despite their proteinuric effects and that 2.) the CUBN locus shows signatures of balancing selection during human evolution. To address this hypothesis, we will first functionally validate common CUBN variants and haplotypes in a humanized Drosophila model and test whether they provide protection against renal disease in mice. Second, we will explore monoallelic CUBN expression and partial cryptic exon inclusion as two possible genetic mechanisms by which CUBN variants could promote proximal tubule fitness and tissue repair. Finally, taking advantage of cubilin dysfunction as a safe means to avoid PTC overload, we will target PTC protein uptake in proteinuric mice with the help of a nanoparticle delivery method. Altogether, our integrative translational approach will combine human genetics and experimental studies to explore a new mechanism of proximal tubule homeostasis that may also be applicable to oth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MODULAR MANUFACTURING AND DISTRIBUTED CONTROL VIA INTEROPERABLE DIGITAL TWINS' (MODAPTO).

assistant: **Innovation**

MODAPTO envisions flexible industrial systems composed of modules enhanced by distributed intelligence via interoperable Digital Twins (DTs) based on industrial standards. Moreover, it materializes enables collective intelligence within modular production schemes for effective module and production line design, reconfiguration and decision support. Motivated by the six principles of Reconfigurable Manufacturing Systems, MODAPTO aims at materializing reconfigurability through the joint use of all principles and not by considering it as an isolated vision of each one. To that end, MODAPTO focuses on two technological pillars: 1. Distributed Intelligence & Control via Interoperable Digital Twins2. Modular Production Framework & Toolkit Within MODAPTO, each production module is augmented by a DT offering additional distributed intelligence functionalities. MODAPTO standardizes the module’s interface via AAS to enable coordination with other modules and systems. MODAPTO also proposes a framework for production design and reconfiguration supported by collective intelligence tools. MODAPTO will be implemented in 3 industrial UCs involving 4 manufacturers at 3 different levels to showcase its versatility and applicability. UC1 targets the development of production modules (robots) with novel sustainability capabilities, while UC2 production reconfiguration and optimization even for single lots. UC3 targets the timely set up of press shop lines and coordination with robots and AGVs to handle supply chain disruptions in collaboration with the producer of semi-finished product kits.MODAPTO aims at substantial KPI improvements related to efficiency, cost, quality, energy and sustainability. Moreover, MODAPTO will develop business models facilitating its transferability to other sec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Harmonizing, Integrating and Vitalizing European Research on hiv/Aids' (HIVERA).

assistant: **Concept**

HIV infection is a major worldwide epidemic threatening public health in all affected countries. Although a wide range of financial support has been successfully dedicated to HIV through national and/or EC-funded programmes, there is still little cooperation between national funding programmes in Europe, while this field is highly international, operationally as well as competitively, in all disciplines of basic, clinical, epidemiology and social sciences. The absence of programme coordination in a context of economic crisis is an important hurdle to confront the emergence of major new questions. Therefore, HIVERA is proposed as a dedicated ERA-NET paving the way for the coordination and cooperation of national programmes, starting first in 8 countries (BE, DE, EE, FR, IT, PT, RO, TR), but flexible enough to integrate new Member States by the end of the Grant duration. During the lifetime of HIVERA, the following actions are intended: exchange of information about participants and programmes, identification of common needs, thorough analyses of synergies and complementarities (data collection, workshops, exchange of programme managers); Preparation and implementation of two joint calls for future joint funding activities and programme opening, with emerging issues in HIV/AIDS as thematic priority; strengthening collaboration between partners of the ERA-Net, including the exchange of researchers and access to facilities; quality assurance for the implementation of common calls and the evaluation of funded research programmes (development of standards); creation of a platform for programme managers and researchers as an interface between science and funding policy to feed into future national and European funding programmes. Duplicating existing European activities will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interdisciplinary and intersectoral doctoral training programme at the Technische Universität Darmstadt in Life Science Engineering' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The presented programme ""trainLSE: Interdisciplinary and intersectoral doctoral training programme at the Technische Universitt Darmstadt in Life Science Engineering"" will lead 15 doctoral candidates (DCs) to their PhD degree within 48 months within the framework of a 60-month MSCA-COFUND action. The doctoral candidates will carry out a research project in the field of life science engineering in one of the excellent working groups with experienced supervisors. In addition, they will complete a comprehensive training programme for the development of transferable skills and scientific communication. TrainLSE aims to establish interdisciplinary research and training of excellent international DCs at the interface between engineering and life sciences. Experienced PIs will offer positions in molecular biology, chemistry, synthetic biology, materials science, (bio)computer science, physics and mechanical engineering. The DCs will be able to uniquely combine expertise from engineering with life sciences and acquire a new constructive, engineering mindset towards biology. These profiles will be in high demand in academia and industry, and will be crucial for the EU's transformation towards a sustainable, climate-compatible economy.TrainLSE will be embedded in the organisation structure of the Graduate School of Life Science Engineering and will be supported by a network of ten associated international academic partners (e.g. ETH Zrich, University of Cambridge, Uppsala University) and ten non-academic partners (Merck Healthcare, BASF, GSI Helmholtzzentrum fr Schwerionenforschung, Institut Pasteur among others) who contribute with secondments and participation in lectures or courses to the education of the DCs. Thus, in addition to the unique interdisciplinary scientific trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Foundations of nonlocal and nonabelian condensed-matter systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Emergent particles with nonabelian exchange statistics are a key element in the understanding of topological condensed matter system. However, the nonabelian nature has never been demonstrated experimentally, nor has the intimately connected nonlocality of quantum states been observed in any physical system. With this proposal, we outline a research program whose goal is to design and carry out experiments, with close theoretical coupling, that can – for the first time – verify or falsify the existence of these fascinating novel degrees of freedom and then, if observed, quantify the spatial and temporal limits for the nonabelian and nonlocal properties. The platform for the research is based on topological superconductivity in hybrid materials, a field in which the applicants have played a leading role. We put together a team of experimental and theoretical physicists in a strongly collaborative setup. The focus of the proposal is Majorana bound states, which exist at the boundaries of topological superconductors. Experiments have over the past five years shown observations consistent with their existence. All these experiments are based on local probes which cannot reveal the inner nature of their nonlocal and nonabelian properties. To address the fundamental aspects of nonlocality, we will design quantum devices that combine topological superconductors with known condensed matter quantum technologies, including quantum dots, two-dimensional electron gases, and fast measurement techniques. The nonabelian nature will be explored by design of multi-Majorana devices and of protocols that can reveal the nonabelian nature of braids in the space of topologically-protected groundstate manifolds. The gained knowledge will provide a breakthrough in the fundamentals of emergent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Accounting for correlated errors with maximum likelihood in crystallography and cryo-EM' under Horizon 2020.

assistant: **Concept**

Proper understanding of the biological processes related to complex macromolecular entities depends on the detailed description of their 3D structures. For 100 years X-Ray Crystallography has been the main player in revealing high resolution structures. In the last decade, Bayesian statistics has yielded a breakthrough for solving challenging structures thanks to the integration of specialised error models essential to extract a weak signal from noisy data. Developed on such statistical methods, the program PHASER implements (along with experimental phasing) the Molecular Replacement technique in which the unknown phases, associated with the experimentally recorded intensities, are estimated from a homologous protein structure. Exploiting a deep new understanding of the link between model, data and phasing success, this technique will be decisively extended by the analysis of multiple models collected into ensembles optimised for likelihood calculations. Recent dramatic improvements in cryo-EM hardware have brought it into the high resolution realm and it is bound to become the main structural technique for the kind of challenging structures at the forefront. The leap from qualitative into quantitative Cryo-EM has already involved algorithmic approaches based on Maximum Likelihood. Generalising its full potential requires new methods that will lead to higher resolution reconstructions. The proposed integration of all sources of error is imperative for difficult samples. In this project, advances in both X-ray crystallography and cryo-EM data-analysis methods are planned, focusing on transferring experience acquired over many years in the first field into the second. Central to this project, the personal development of the experienced researcher will broaden his field of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REVOLUTIONARY THERAPY OF APHASIA' (VOIC) targeting Horizon 2020.

assistant: **Abstract**

Home therapy is the future of many available medical therapies. Home therapy does not require any additional medical staff support or hospital space, resulting in large savings for healthcare services. Aphasia therapy is one which could be potentially moved to the home setting, resulting in great benefits for patients. Aphasia is a kind of brain damage caused mainly by a stroke which prevents a person’s linguistic communication while maintaining the intellect intact. It is independent of age or sex, hence everyone is at risk - every year in EU there are almost 300 000 new cases.  Most important for aphasia therapy is to start directly after it is diagnosed. Neuro Device Group with project VOIC aims at providing easy to use neuro-stimulation medical device coupled with software to provide the therapy at home setting. Currently, there is no dedicated device for aphasia therapy on the market, hence VOIC is a market-creating innovation. Our proposed therapy is more efficient and costs much less than the state-of-the-art standard speech therapy with a neuro-therapist. VOIC will be offered to patients such that the therapy starts quickly at a lower cost of a few thousand euros. We also want to offer VOIC to the therapists who can attend more patients at the same time, providing an additional source of income and patient satisfaction. The indirect benefit of the healthcare and retirement systems cannot be underestimated: lower cost of therapy and reduced cost of social benefits per patient, which can sum up to €3bn savings every year. The project will be well aligned with the company strategy and global trends in medical treatment. The market for medical devices is rapidly growing at 14% CAGR and is going to reach €13bn in 2023. The market demand has been initially confirmed w