RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Infinite-dimensional space-time processes in euclidean and minkowskian spaces' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The theory of infinite dimensional processes in Euclidean spaces is an active field of research, with applications to Markov fields, quantum fields and different models of statistical mechanics. Moreover, connections with stochastic partial differential equations have been established. On the other hand, an analogous theory for space-time processes in Minkowskian spaces is still missing, due to the difficulties connected with the pseudo-Riemannian structure. Our objectives are mainly the following: to study in detail the stochastic processes arising in the comoving coordinates approach , in view of possible applications to infinite dimensional diffusions both in Euclidean and Minkowskian spaces; to compare this approach with the clock space one and to look for explicit connections: to extend in the relativistic setting the results recently obtained on the approximation of Gaussian measures via Poisson measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering the dynamic-plasticity and heterogeneity of cancer-associated fibroblasts' (DynamHet).

assistant: **Innovation**

Cancer-associated fibroblasts (CAFs) are one of the most abundant and versatile cell types in the tumour microenvironment (TME), where they crosstalk with stromal cells and actively participate in tumour development. Because of their assumed pro-tumourigenic functions, CAFs have long been considered an attractive therapeutic target. However, recent evidence indicates that multiple CAF subpopulations showing inflammatory, myofibroblastic, vascular, antigen-presenting, and immunosuppressive phenotypes co-exist within the same tumour,  with some promoting and other restricting tumour growth; thus, making their targeting challenging. How CAFs change dynamically as cancers evolve, and how this may affect the overall tumour heterogeneity, remains unaddressed. Therefore, the main goal of DynamHet is to elucidate the origin and evolution of CAF heterogeneity and to decipher the mediators and mechanisms that regulate CAF plasticity as the tumour advances. This is crucial for the development of effective therapies aimed at reprogramming CAFs towards therapeutically favourable phenotypes and will constitute a great breakthrough in the field of oncology. Hence, DynamHet aims to 1) decipher the origin of CAF heterogeneity by performing clonal tracing and by generating and characterising CAF subtypes starting from human induced pluripotent stem cells; 2) dissect CAF-TME crosstalk by generating 3D patient-derived organoids and spheroids and by analysing their secretome and transcriptomic profiles using high throughput technologies and computational analysis; and 3) reprogramme CAFs by genetic manipulation in favour of therapeutically advantageous subpopulations as a novel therapeutic approach. DynamHet is an ambitious and feasible project that stands as a pioneer in the new concept of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The detection of boundary changes as a method for early diagnosis of cardiovascular disease' (CARDIO-DETECT) under Seventh Framework.

assistant: **Objectives**

Current clinically approved methods for detection of Cardiovascular Disease have a number of associated disadvantages and limitations. All methods have some reliability issues and most are based on detection of plaque. Once plaque already exists however, disease may have been getting progressively worse for decades. Methods based on detection of plaque are therefore not able to detect the disease in the early stages. Better diagnostic methods, especially for early detection, are therefore urgently needed and will provide a great improvement on existing methods. A major problem in establishing better diagnostic methods is the large scientific gap which exists between clinicians and scientists, making communication extremely difficult. This proposal will use the unique skill-set of Russian scientist with formidable clinical knowledge and the highest level of mathematical and computational skills to transfer clinical knowledge to the scientific community. This proposal will use this unique skill-set to establish the necessary scientific basis to pursue new methods to detect cardiovascular disease earlier and more reliably than presently possible. The essence of the approach is that material changes must occur at the inner boundary of the artery in the very earliest stages of disease. This novel approach will use advanced asymptotic long wave methods developed by the UK host and will determine changes at the inner boundary through changes to the expected dispersion spectrum. The results from this project will provide the urgently required framework to supply a scientific benchmark, enabling new diagnostic equipment to be developed; this will not only save and improve quality of life, it will significantly reduce the financial cost of treatment and long term care of cardiova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INnovative INtegral approach for WOOD waste depollution and multi-sector valorization' (WoodTreat), addressing dissemination and exploitation.

assistant: **Impact**

According to today’s practice, wood waste is roughly classified into three or four classes, depending on the country. The most polluted grade, often referred to as grade C or AIII/AIV, consists of preservative-treated wood, i.e. wood that has been impregnated with chemicals (pesticides, biocides and fungicides) to enhance its bio-resistance. Grade C or AIII/AIV is not currently recycled. The increased use of wood as encouraged by initiatives like the New European Bauhaus is likely to require additional volumes of preservative-treated wood. Even though such treatments extend the service life of wood products, they will still eventually become waste and must be dealt with. Wood preservation compounds pose a significant threat to not only the environment but also to human health, and therefore it is needed to develop efficient remediation technologies. At the same time, current recycling processes are greatly complicated by the presence of pollutants (chemical treatment products, heavy metals), which calls for further research on cleaning methods. As grade C comprises of several types of wood types and products, along with different levels of contamination, this poses a complex problem that needs action from both the circular economy and non-toxic environment fields. The development of an automated on-line characterization system to distinguish chemically contaminated wood waste has become a high priority. Gaps in existing regulations should be considered as may not fully support the use of upcycled wood materials from such waste streams. IN2WOOD proposes a multi-dimensional cascade approach for highly polluted post-consumer wood waste via a series of seven Pilot Validation Trials (PVTs) with aim to reduce the demand for virgin materials, reduce unsustainable options such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Missing Link of Episodic Memory Decline in Aging: The Role of Inefficient Systems Consolidation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Which brain mechanisms are responsible for the faith of the memories we make with age, whether they wither or stay, and in what form? Episodic memory function does decline with age. While this decline can have multiple causes, research has focused almost entirely on encoding and retrieval processes, largely ignoring a third critical process– consolidation. The objective of AgeConsolidate is to provide this missing link, by combining novel experimental cognitive paradigms with neuroimaging in a longitudinal large-scale attempt to directly test how age-related changes in consolidation processes in the brain impact episodic memory decline. The ambitious aims of the present proposal are two-fold: (1) Use recent advances in memory consolidation theory to achieve an elaborate model of episodic memory deficits in aging(2) Use aging as a model to uncover how structural and functional brain changes affect episodic memory consolidation in generalThe novelty of the project lies in the synthesis of recent methodological advances and theoretical models for episodic memory consolidation to explain age-related decline, by employing a unique combination of a range of different techniques and approaches. This is ground-breaking, in that it aims at taking our understanding of the brain processes underlying episodic memory decline in aging to a new level, while at the same time advancing our theoretical understanding of how episodic memories are consolidated in the human brain. To obtain this outcome, I will test the main hypothesis of the project: Brain processes of episodic memory consolidation are less effective in older adults, and this can account for a significant portion of the episodic memory decline in aging. This will be answered by six secondary hypotheses, with 1-3 experiments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photography in the Making of Knowledge: European Art-historical and Scientific Investigations on Asia' (PhotoMaKEASIA).

assistant: **Concept**

The history of photography shares a profound connection with the history of the modern scientific disciplines, including art history, anthropology, and archaeology, as well as modern medicine, biology, and the natural sciences. With the visual turn in the humanities, an increasing number of historians have analyzed visual materials from a new perspective, conceiving images as central rather than peripheral objects of historical analysis. Images ranging from early X-ray photographs to drawings of distant cultures contributed in different ways to the production of knowledge. All provided viewers with an impression that they were seeing something that would otherwise be invisible to them, whether inside the human body or geographically and ideologically distant. The PhotoMaKEASIA project addresses the following questions: How did European scholars and scientists use photography to construct knowledge about Asia? To what degree did the photographic medium itself influence or affect the results of their studies? Do contemporary photographs of Asia continue to shape scholarly and popular understandings? Departing from studies that focus on photography and the “colonial gaze,” this project concentrates instead on how photographs shaped knowledge in response to pragmatic concerns and scholarly interest in Asia. The project develops four case studies: 1.) photographs of 1850s European expeditions to China to study silkworm cultivation; 2.) images created to document archaeological expeditions by the ISMEO (Rome); 3.) photographic reproductions of artworks used in art historical studies; 4.) and contemporary documentary photography. Based on these four studies, the project will trace the history of photographic images in the construction of European knowledge about Asia in order
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Responses of RiParian forests to hydroPeaking: towards a sustainable hydropower management' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Hydropower is considered a renewable energy source and its demand is considerably increasing in Europe. However, its global benefits are accompanied by significant environmental losses. Hydropeaking constitutes a major impact from hydropower dam operation. It refers to frequent changes in river flow occurring within the span of a day caused by turning the turbines on or off in response to varying demand in the energy market. As a result, downstream and upstream river hydrology, hydraulic parameters, water quality, river morphology, and ultimately the fluvial ecosystem, are modified. Despite the increasing environmental, social, industrial and regulatory requirements with regard to hydropower production and river ecological status in Europe (and worldwide), there is still much to learn about ecological processes affected by sub-daily flow changes along regulated rivers. Scientific studies are scarce and most of them focus on fish, leaving riparian vegetation uninvestigated. Hydropeaking may spoil the recruitment of riparian species and hence affect the maintenance of riparian populations. By analysing seed germination and seedling performance, it may be possible to reveal predictable relationships between hydropeaking and vegetation responses. Such relationships are crucial so as to objectively define thresholds which help to minimize the ecological effects of hydropower generation without causing significant production loss. The aim of this project is to investigate the opportunities for sustainable management of rivers subjected to hydropower production. To accomplish this goal, a thorough literature revision, analysis of sub-daily flow series, vegetation field-experiments and computer modelling are planned. The expected new contributions from the project are: (1) hydr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Production Networks in Macroeconomics' in the context of a Seventh Framework call.

assistant: **Objectives**

A modern economy is an intricately linked web of specialized production units, each relying on the flow of inputs from their suppliers to produce their own output which, in turn, is routed towards other downstream units. Recent work in economics stresses that the structure of this production network is key in determining whether and how microeconomic shocks can propagate throughout the economy and shape aggregate outcomes.This project has two main goals. First, it aims to provide novel evidence that we can trace back the origins of business cycles and asset price fluctuations to individual technologies interconnected by input-supply relations. The particular questions it tries to answer are: (1) Can we have more direct, causal, evidence that these micro shocks do matter in practice for the evolution of aggregates? What are examples of these micro shocks in reality, how can we identify them and how do they propagate through input chains? (2) What are the asset pricing implications of this perspective on the micro origins of aggregate fluctuations? What is the relation between changes in the technology portfolio of an economy and the evolution of asset prices?The second aim of this project is to improve our understanding of the structure and evolution of these production networks by asking the following questions: (3) At the firm level, do more productive suppliers match with more productive customers and, if so, why? What is the typical duration of a supplier-customer match and does this vary across matches? What is the firm-level impact of matching with better suppliers or more productive customers? (4) How do inputs diffuse on a network of interconnected technologies? Do linkages across sectors facilitate input adoption and the diffusion of General Purpose Technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Challenges of biomedicine - socio-cultural contexts, European governance and bioethics'.

assistant: **Objectives**

This project is to investigate the influence the European public and the biomedical science exert on each other. This bio-political relationship will be examined by analysing the variety of important concepts such as 'identity', 'citizenship', and 'integri ty of human body' and to what extent biomédical science interacts with them. The significance of this interaction will be examined in two dimensions: 1. opportunities of participation and governance of medicine and 2. cultural plurality and diversity of pu blic preferences towards biomedicine (esp. genetic testing & transplantation medicine). The cross-cultural comparative investigations will be done in an interdisciplinary team from 8 different countries in Northern, Southern, Western and Eastern Europe . Empirical data of lay people and patients attitudes towards participation and cultural aspects of biomedicine will be recorded by focus group discussions, interviews and ethnographic studies. The analysis is organised in three sub-projects: A) The forms of medicalisation and geneticisation and their interaction with concepts of 'body', 'health',and 'identity' B)Ethical reflection on cultural diversity, governance and participation. C)The interference between public understanding of science and participat ion/governance in cultural contexts. The synopsis of these sub-projects will clarify: 1.How governance of science and medico-ethical standards in Europe can be harmonised with cultural variety and multitude of preferences. 2.How and to what extent lay peop le and patients should participate in decision processes in health care and medical institution. 3.The role the various actors, stake holders, lay people, scientists and policy makers could play in European governance of science and clinical research. The results
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Smart MAterial System to enHance the service life of reinforced concrete structures'.

assistant: **Innovation**

Sustainable development is one of the main challenges that humanity has to face to progress. The construction industry strongly influences the achievement of this goal, as it heavily impacts on resource and energy consumption, waste production, greenhouse gas emission. The extension of the service life of structures will be one of the measures necessary for this sector to support sustainable development, since it can save resources, decrease the carbon footprint and reduce waste production. Reinforced concrete structures (RCS) represent the vast majority of the built environment, so research efforts should be focused especially on this type of structures. One of the most promising approaches to prolong the service-life of RCS is the development and implementation of Smart Structures, being structures able to sense some external stimuli, process the information and respond autonomously in real time by using smart materials technologies. Research on this topic is advancing, but it is still a challenge to achieve efficient systems.The final goal of SMASH is precisely to develop an efficient “Smart Material” system to be implemented in RCS in order to enhance their service life, on the way to sustainable development. The key enabling technologies to develop this system will be capsule-based self-healing and voltammetric sensors, combined together to produce a synergic effect.With the support of my supervisor (Prof. Paola Antonaci) and her extensive knowledge in the development and characterization methods for innovative building materials, the fellowship will train me in the frontier fields of self-healing and advanced repair technologies, complementing my expertise on sensor systems. Ultimately, SMASH will provide a crucial contribution to relevant research on the reductio