RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The interplay between quantum coherence and environment in the photosynthetic electronic energy transfer and light-harvesting: a quantum chemical picture' (ENLIGHT).

assistant: **Innovation**

Photon energy absorption and electronic energy transfer (EET) represents the first fundamental step in both natural and artificial light-harvesting systems. The most striking example is photosynthesis, in which plants, algae and bacteria are able to transfer the absorbed light to the reaction centers in proteins with almost 100% quantum efficiency. Recent two-dimensional spectroscopic measurements suggest that the role of the environment (a protein or a given embedding supramolecular architecture) is fundamental in determining both the dynamics and the efficiency of the process. What is still missing in order to fully understand and characterize EET is a new theoretical and computational approach which can reproduce the microscopic dynamics of the process based on an accurate description of the playing actors, i.e. the transferring pigments and the environment. Such an approach is a formidable challenge due to the large network of interactions which couples all the parts and makes the dynamics of the process a complex competition of random fluctuations and coherences. Only a strategy based upon an integration of computational models with different length and time scales can achieve the required completeness of the description. This project aims at achieving such an integration by developing completely new theoretical and computational tools based on the merging of quantum mechanical methods, polarizable force fields and dielectric continuum models. Such a strategy in which the fundamental effects of polarization between the pigments and the environment will be accounted for in a dynamically coupled way will allow to simulate the full dynamic process of light harvesting and energy transfer in complex multichromophoric supramolecular systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A coordinated approach to access, experimental development and scientific exploitation of european large infrastructures for high magnetic fields' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

It is the purpose of this integrated infrastructure initiative (1) to co-ordinate the transnational access to three main large infrastructures of high static and pulsed magnetic fields (HFML, Nijmegen, the Netherlands; LNCMP, Toulouse, France; and IFW, Dre sden, Germany), and a number of smaller pulsed field installations in Berlin, Leuven and Zaragoza, (2) to develop new experimental possibilities at these infrastructures by two Joint Research activities involving other groups, and (3) to foster exchange of information between the infrastructures and between various user groups by forming a network of scientific groups using high magnetic fields. Transnational access is offered to static magnetic fields up to 33 T, pulsed magnetic fields to the 60-100 T ran ge, and the development programs will focus on high-field NMR and infrared spectroscopy in pulsed fields. This I3 proposal encompasses practically all of the European activity concerning high magnetic fields in all three areas of Access, Development and Re search. It is expected that this step will have a strong integrating effect on the European activities in the area of high magnetic fields, leading to the distributed European Large Magnetic Field Facility anticipated in the ESF report The scientific case for a European Laboratory for 100 Tesla Science"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting a Novel Mechanism of Cell Motility' to be submitted under Seventh Framework.

assistant: **Abstract**

Cell motility is essential for many biological processes, including development and pathogenesis. Thus, themolecular mechanisms underlying this process have been intensively studied in many cell systems, forexample, leukocytes, amoeba and even bacteria. Intriguingly, bacteria are also able to move across solidsurfaces (gliding motility) like eukaryotic cells by a process that has remained largely mysterious. Theemergence of bacterial cell biology: the discovery that the bacterial cell also has a dynamic cytoskeleton andspecialized subcellular regions now provides new research angles to study the motility mechanism. Usingcell biology approaches, we previously suggested that the mechanism may be akin to acto-myosin-basedmotility in eukaryotic cells and proposed that bacterial focal adhesion complexes also power locomotion. Inthis project, we propose two complementary research axes to define both the mechanism and its spatialregulation in the cell at molecular resolution.Using the model motility bacterium Myxococcus xanthus, we first propose to develop a “toolbox” ofbiophysical and cell biology assays to analyze the motility process. Specifically, we will construct a TractionForce Microscopy assay designed to image the motility forces directly by live moving cells and usemicrofluidics to quantitate the secretion of a mucus that may participate directly in the motility process.These assays, combined with a newly developed laser trap system to visualize dynamic focal adhesions inthe cell envelope, will be instrumental not only to define new features of the motility process, but also tostudy the function of novel motility genes which may encode the components of the elusive motility engine.This way, we hope to establish the mechanism and structure function relationships withi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TrUsted Revocable Biometric IdeNtitiEs' under Seventh Framework.

assistant: **Concept**

TURBINE is a multi-disciplinary privacy enhancing technology, combining innovative developments in cryptography and fingerprint biometrics. It aims at providing highly reliable biometric 1:1 verifications, multi-vendor interoperability, and system security, while solving major issues related to privacy concerns associated to the use of biometrics for ID management. Its primary objective is to render this innovation commercially viable by demonstrating that the technology is sufficiently mature for deployment as a solution to large scale eID requirements. To achieve this it will develop and evaluate the foundation and application of revocable protected biometric templates and pseudo-identities using fingerprint data. Use of different biometric enrolment algorithm transformations and hence subsequent verification mechanisms will be evaluated against public and private fingerprint databases. Specific objectives will be to ensure that the crypto-protection deployed on the biometric data is non-invertible and has the lowest possible impact on biometric verification performance. Project results will be assessed using very large fingerprint data bases held by two project partners to compare performances with and without crypto-protection. Expert groups will be included in the project to advise the consortium on i) data protection and privacy issues and ii) requirements of key application sectors for eID management solutions. Furthermore, a comprehensive verification test and demonstration environment will evaluate how single fingerprint data of an individual may be used to generate several secure identities with different levels of trust. It will include revocation and issuance of an equivalent re-generated biometric identity based on the same specific fingerprint data without
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Large Scale Industrial Structural Optimisation for Advanced Applications' under Seventh Framework.

assistant: **Concept**

The overall goal of LaScISO (Large Scale Industrial Structural Optimisation for Advanced Applications) is to enhance structural optimisation methods to be capable of optimisation with current industrial state-of-the-art simulation techniques, i.e. to “optimize what can be simulated”. This requires a tight cooperation between leading research institutions and industry within the fields of numerical optimisation, structural mechanics and software engineering.Current industrial structural optimisation software packages are capable of optimizing linear static and modal finite element (FE) modelled structures. The optimisation is mainly carried out by the CAE (computer aided engineering) simulation groups which are typically also in charge of carrying out more complex simulations involving multiphysics effects and different types of nonlinearities. The demand for optimisation tools which can handle the latter is obvious because many effects can only be investigated and controlled by using these analysis methods. To solve these optimisation problems in an efficient and flexible way, sensitivity based optimisation methods must be extended to cope with multiphysics and nonlinearities. This requires skill in development of new methods and software capabilities. With the consortium consisting of different specialists within the project area, it will be ensured that all skills needed to overcome the current limitation are available such that current state-of-the-art large scale simulations may be used directly in optimisation with good performance.The benefit of LaScISO is a faster and more cost-efficient simulation driven European product development. The optimisation methods will provide a competitive advantage over non-European developers to create low-weight, CO2-saving high q
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BIHC- Bio-inspired models of human crowds' (BIHC).

assistant: **Concept**

With current consumer-grade personal computers, it is possible to display 3d virtual scenes with thousands of animated individual entities at interactive frame rates. Crowd simulations are, however, too often limited to characters lacking individuality and wandering in an environment without a specific goal. This situation is particularly problematic in the field of cultural heritage in real-time simulations of the past where the  realism of individual behavior is critical. This proposal, through a collaboration across the computer science and the archaeology fields, seeks to address this problem. It aims at exploring bio-mimicking techniques in the development of a generative model for heterogeneity and spontaneity in behavioral animation of crowds. More specifically, the goals can be defined as (i) the development of a bio-inspired model of agency for virtual humans (which upgrades a previous prototype, part of my earlier research), (ii) the development of an authoring tool to interact with the parameters of that model and develop context-specific behaviors/animations, and finally (iii) the development of a proof-of-concept - the simulation of a historical  environment, with the assistance of non-programmers using the authoring tool developed earlier.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart phoTonic souRces harnEssing Advanced Multidimensional Light optimization towards machIne-learNing-Enhanced imaging' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Modern photonic systems increasingly rely on complex nonlinear optical processes at the foundation of demanding applications spanning advanced light source development, metrology and imaging. Importantly, current flagship imaging systems are based on nonlinear light-matter interactions provided by specialized lasers requiring complex operation and lacking tunability: means of controlling nonlinear phenomena and interactions are restricted, and reaching the ideal settings for a specific application can prove extremely challenging.In this context, optical excitations can be inefficient (with e.g. excessive power or spectral coverage) and versatile means to drive coherent control of light properties are highly sought-after, for they provide the main building blocks for advanced imaging techniques. However, such control is currently constrained to few degrees of freedom provided by complex components ultimately hindering the accessible optical parameter space.The realization of versatile, efficient and practical optical sources in compact forms would thus represent a fundamental revolution.STREAMLINE constitutes an ambitious multidisciplinary program aiming to push forwards the development of 'smart photonic sources' for the creation of a promising new research field merging ultrafast nonlinear optics and computational imaging. The envisioned architecture, combining integrated and fibered components, will explore new multimode and input-dependent nonlinear dynamics via dedicated machine-learning schemes.Together with suitable monitoring techniques, fully reconfigurable and tailored optical wavepackets (with ‘on-demand’ spectral, temporal and spatial properties), will be exploited towards disruptive nonlinear imaging and metrology techniques. Besides providing user-friendly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Summer School in Analysis', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The outcome of this proposal will be a series of three very high level Euro Summer Schools in Mathematical Analysis. The principal aim of the series is the training of young researchers from the EU and Associated States, to provide them with the information and contacts to further their research over the next decade. Mathematical Analysis is an area of central importance within mathematics, and in this series it is intended to treat three topics - MATHEMATICAL ANALYSIS OF HYDRODYNAMICS, OPERATOR THEORY, and ANALYSIS AND COMPUTATION: THEORY AND ALGORITHMS.Each of these reaches out not only to other areas of analysis, but also to other areas of mathematics, science and technology. These topics are at the forefront of current international developments. Each Summer School will consist of around 15 lecture courses, usually in the form of three one-hour lectures, given by leading international experts who are also renowned for their expository skills. The formal lectures will also be supplemented by tutorial sessions. Eighty participants are expected to attend each Summer School, with around 40 to be funded through this proposal. The Summer Schools will last 11 to 12 days and will be carefully structured so that the more elementary and familiar material is presented first, and the cutting-edge state-of -the-art research at the end. The host organisation - the International Centre for Mathematical Sciences (ICMS) - has over a decade of experience in hosting research level conferences of many sorts. In particular, every year since 1993, it has organised instructional courses in analvsis of a verv similar type and scale to those proposed here.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Histamine H3-Receptor Antagonists as Cognitive Enhancers in Alzheimer's Disease', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The major objective of the program is to design, to develop pharmaceutically, and to assess the clinical utility of antagonists of the histamine H3-receptor (H3R) as cognitive enhancers in elderly subjects, particularly patients with Alzheimer disease.Animal behavioural and human neuropathology data suggest that H3R antagonists, a novel class of drugs never submitted to clinical trials so far, hold promise in the field of Alzheimer's disease. They enhance histaminergic neurotransmission in the CNS, improve wakefulness and learning in animals, and histaminergic neurones seem largely spared in Alzheimer brain. Hence a novel therapeutic strategy based upon cognitive enhancement via facilitation of histamine release from relatively spared neurones.In the present program the scientific basis for the alleged therapeutic application will be set up by i) cloning the human H3R and using it to assess the activity of already available and future, rationally-designed H3R antagonists, ii) assessing the status of the histamine receptor subtypes in Alzheimer brain by post-mortem neuropathology and PET Scan studies, two approaches for which novel probes will be developed, iii) assessing the cognitive-enhancing activity of selected H3R antagonists drugs on animal models of wakefulness, attention and learning.The pharmaceutical development, undertaken by a novel pharmaceutical research SME, will comprise in vitro and in vivo toxicity studies, pharmacokinetics and clinical studies up to Phase II in order to validate the alleged indication.The present project has high chances of success in spite of its novelty and short time schedule. Indeed, it involves a number of partners who i) were at the origin of the discovery of the histamine H2 and H3 receptors and design of their first ligands an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Creating and disseminating novel nanomechanical characterisation techniques and standards' (NANOINDENT), addressing dissemination and exploitation.

assistant: **Impact**

Our project aims to gather, improve, catalogue and present characterisation techniques, methods and equipment for nanomechanical testing. European-wide activities coordinated by a new virtual centre will improve existing nanoindentation metrology to reveal structure-properties relationship at the nano-scale. These methods are the only tools to characterise nanocomposite, nanolayer and interface mechanical behaviours in the nanometre range. This work will also lay down a solid base for subsequent efforts for defining and preparing new standards to support measurement technology in the field of nanomaterials characterisation. Steps include development of the classical and the dynamic nanoindentation method and its application to new fields, application of modified nano-indenters to new fields as scratching and wear measurement, firm and uniform determination of instrumental parameters and defining new standard samples for the new applications. The virtual centre will disseminate information based on a new “Nanocharacterisation database” built on two definite levels: on a broader level partners will inventory and process all novel nanocharacterisation techniques and, in narrower terms, they will concentrate on nanomechanical characterisation. This will be achieved through the synchronisation of efforts set around a core of round robins but the database will include data of other channels as parallel research work and literature recherché.  Core activities comprise detailed dissemination activities. Indirect connections to the stakeholders by a webpage with a build-in interactive database will be complemented by direct events such as participation in workshops (oral and poster presentations), and regular technical reports in international journals.  Activities above will le