RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synthesis of non-uniformly isotope labelled - nmr-window" - biologically functional dna and rna and their conformational study by high-field nmr"', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

NMR spectroscopy is one of the most useful approaches to understand how the structure and dynamics of DNA or RNA an their interactions with various ligands dictate their specific biological functions under closely physiological condition. It It been demonstrated in Prof. Chattopadhyaya's lab (i.e. the host lab) that the use of non-uniform but specific deuterium labelled large DNA and RNA solve the resonance overcrowding problem of IH-NMR spectra of natural DNA and RNA (Tetrahedron) 48, 9033 (1992); ibid, 51, 100065 (1995)). The host lab has also developed large scale synthetic methodologies for a deuterated nucleotide blocks for the automated solid-phase synthesis in order to introduce the NMR-window in large oligo- RNA and DNA, in conjunction with natural ones. The first proof of this NMR-window concept has been unambiguous demonstrated through the synthesis and NMR structure determination of a 20-mer self-complementary DNA duplex (Nucleic acid Res., 21, 5005 (1993)), a 21 mer RNA hairpin loop (Nucleic acid Res., 24 1187 (1996)) and a 31-mer RNA subunit of RNase P RNA (Nucleic acid Res., 24, 2022 (1996)). These findings clearly show that the NMR- window concept indeed simplifies the NMR spectra enormously for the NMR structure determination of large biologically-ffinctional DNA and RN molecules. We herein propose to devise appropriate synthetic routes for triple-labeled oligo-DNA and -RNA in which 13C and 15N labels will be included in the NMR- window part, and the regions outside the NMR- window will be fully-deuterated to afford the non-uniformly isotope labelled biologically functional DNA and RNA. These triple-labeled oligo-DNA/RNA and their complexes with various ligands are ideally suited for determination of their tertiary structures and dynamics by triple reson
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Sepsis Academy: towards new biomarkers to improve sepsis management' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

ESA-ITN will break through the state of the art in sepsis diagnostics and will train 15 early-stage researchers (ESRs) todetermine the clinical potency of a variety of new complementary sepsis biomarkers. These cover the full range of the antiinflammatory response in sepsis, at genetic, molecular and cellular level. Rapid and practical biomarker diagnostics forsepsis will be developed by building on some of the world's most innovative diagnostic platforms. In addition, a whole newclinical research model that incorporates use of biomarker diagnostics will be designed and tested.All 15 interlinked ESR projects have an interdisciplinary component (intersection of sepsis research, product development,economics and medical practice) and international (representing 10 countries) and industry collaborations (incorporating 3diagnostics firms, 1 bioinformatics company and a business school). Interactions within the network are strengthened bymeaningful secondments, which take place at private beneficiary or partner institutes.The training programme covers:1. Specialist training in an international, interdisciplinary and intersectorial sepsis-orientated research project;2. Advanced technology training in pathogenesis, biomarker discovery, diagnostics, trial design and innovation management;3. Professional training in transferable skills, including the special ESA-ITN mini-MBA.The setup of ESA-ITN is unique as it reflects the entire innovation value chain for sepsis biomarker diagnostics. ESA-ITN iscomposed of leading institutes in sepsis research and a selection of Europe's top biomarker diagnostics companies. Links tovarious global networks and shared research infrastructures in the field of sepsis further leverage the proposition of ESA-ITN.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BodyElectric: Unlocking the Potential of Electrotactile Haptics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

BodyElectric will develop a new form of haptics using electrotactile stimulation to transform our ability to incorporate tactile feedback into everyday products, to create richer interactive experiences, with lower environmental cost.Tactile haptics is a key feature of many devices, from phones to in-car user interfaces, significantly improving usability and user experience. However, touch is limited to vibration. Vibration actuators are bulky, low bandwidth, use non-sustainable materials, and only evoke a very limited set of sensations. This means we cannot make full use of our powerful touch sense and limits the applications of haptics.  Electrotactile stimulation is the only effective solution for adding tactile displays to flexible devices with different geometries, at a low cost, power consumption and complexity. However, there are 4 key challenges that must be addressed:. Perception – Knowledge of how electrical stimulation is perceived is limited; we have no clear basis on which to design comfortable, safe and effective stimuli. Electrode Design – There are no sustainable electrodes, printable on to the surfaces of everyday devices to deliver stimulation. Impedance Changes - Skin impedance and sensitivity vary over the body and over time; the same level of stimulation could become painful (or imperceptible) if the user sweats or moves their body. Interaction Design - Little is known about how to design effectively using electrotactile haptics and there are no tools to helpOur vision to solve these problems requires ground-breaking work at the intersection of HCI, psychology and biomedical engineering to:1 Conduct fundamental studies in the perception of electrotactile stimulation 2 Engineer sustainable electrode hardware and closed-loop impedance sensing for pers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Testing the Standard Model through CP Violation in B mesons' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

One of the most challenging and fascinating problems in science is to understand the origin of the Universe. Particularly mysterious is the source of the matter-antimatter imbalance, which lies in the violation of CP symmetry. Studies of this phenomenon may reveal sources of new physics, beyond our current comprehension. CP violation can be investigated experimentally by studying the behaviour of beauty" particles, which contain a b quark.Currently, the most precise of these studies come from experiments known as "B factories" such as the Belle experiment at the KEK laboratory in Japan. A different and complementary approach to the study of beauty particles will be adopted by the LHCb experiment, at CERN. Data taking will start when the Large Hadron Col lider (LHC) becomes operational, in 2007. It is essential for the successful operation of LHCb, to reduce the enormous event rate through effective online event selection (triggering).This must incorporate the most up-to-date and accurate existing knowledge of CP violation, such as the results coming from the Belle experiment. Belle has accumulated a very large data sample, and is at the peak of its scientific productivity. The project involves developing optimal trigger strategies for LHCb. This incorporates CP violation studies at Belle, and the porting of these results to LHCb.Through these studies, and the development of expertise in the LHCb electronics and data flow, the researcher will help to maximize the physics capabilities of LHCb. Efficient and effective trigger strategies will be designed and implemented, and the first data from LHCb will be analysed, within the Grid framework. The project will enable the researcher to return to Europe from Japan, and to re-establish himself in the European community."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Protist evolution in suboxic worlds' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

How and when eukaryotes evolved remain major open questions. Also the phylogenetic relationships and the emergence order of major eukaryotic lineages remain unresolved, despite progress in phylogenomic analyses based on genome and transcriptome data across the eukaryotic tree. However, this information is biased towards multicellular taxa. Yet, environmental molecular analyses have uncovered a vast diversity of protists (broadly, microbial eukaryotes), many of which have uncertain phylogenetic position. Phylogenomics also suggests that endosymbiosis (e.g. mitochondrial acquisition) played a key role in eukaryotic evolution, shaping their genomes and leading to innovations. The first eukaryotes likely evolved in anoxic or transition-to-oxic (suboxic) environments, which may hold clues as to the occurring selective constraints, prior to colonizing new niches thanks to oxygen-respiring mitochondria. Despite so, little is known about the diversity and mode of evolution of eukaryotes in suboxic worlds, including microbial mats and stromatolites, where many inter-species interactions are likely to exist. I propose an integrative interdisciplinary approach to gain significant knowledge about early eukaryotic evolution according to the following hypotheses: i) High diversity suboxic environments, such as microbial mats, hide novel divergent protist lineages. ii) The study of natural fossilization processes of microbial eukaryotes in calcifying microbial mats such as stromatolites will lead to the definition of biosignatures in the past fossil record and to establish reference dates for the origin of eukaryotes and/or particular eukaryotic taxa. iii) Phylogenomic analysis of divergent protist lineages from suboxic environments will help resolving the eukaryotic tree of life and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an SPR-based biosensor for the detection of lipophilic phycotoxins in shellfish residues' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Lipophilic phycotoxins are often found in high levels in bivalve molluscs, echinoderms, tunicates ormarine gastropods and the consumption of these contaminated seafoods can pose a significant threatto human health. There is a need to monitor levels of these toxins in seafood meant for humanconsumption and to keep levels below defined thresholds. In Europe the broad spectrum mouse or ratbioassay is the only official method for the detection of these toxins, although recently directives wereapproved stating that any functional method could be used to replace the bioassay if fully validated.The overall objective of this project is to develop a multi-channel, high-throughput biosensor for the detection of diarrheic shellfish toxins, yessotoxins, pectenotoxins, azaspiracids and gymnodimine. Theproposed biosensor will exploit the phenomenon of Surface Plasmon Resonance (SPR) to detect andmeasure these lipophilic phycotoxins in seafood residues. The sensor will be designed as an inhibitionassay capable of rapid, reliable multi-toxin detection. The technology allows real-time, automated,multiresidue analysis of food products, both in laboratories and at on-site locations and is capable ofmeasuring coloured, turbid or opaque sample solutions. The assembled consortium has a great dealof experience in their respective fields and demonstrates a high level of complementarity. The projecthas the required expertise and resources required to carry out the development of this valuable newtechnology, which has the potential not only to eliminate the need for the ethically concerningbioassays currently used, but also to provide a simple, cheap and improved method for the detectionof phycotoxins in shellfish residues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'How spontaneous telomeric fusions occur: unravelling new pathways required for end protection'.

assistant: **Innovation**

Telomeres are DNA-protein complexes that reside at the end of the chromosomes. These are key structures in order to prevent loss of genetic information and DNA damage activation at the chromosome termini, thus avoiding genomic instability, which can potentiate tumorigenesis. When a telomere became dysfunctional, for example by loss of telomeric proteins or due to telomere shortening, the DNA damage machinery is activated and the chromosome ends are processed as DNA breaks. This leads to checkpoint activation and repair through chromosome end-joining. Although many have studied how telomere fusions arise in the absence of key telomeric components, the formation of spontaneous end-to-end fusions is still poorly understood. Here we propose to dissect how spontaneous telomere fusions arise. For that we will use as model organism Schizosaccharomyces pombe, which telomeres have great similarities with the mammalian ones. Using a state-of-the-art plasmid assay we will conduct a transposon-based genetic screen in order to unravel new proteins required for the formation of telomeric fusions in a wild-type and unperturbed system. We will then focus on the clearest candidates from the screen and determine their role in telomere biology. Moreover, and in order to further understand how spontaneous telomeric fusions arise, we also aim to investigate the role of telomeric replication in this process. The fact the telomeres are long stretches of repetitive DNA sequences and also due to the formation of secondary structures, replication can be a challenging event, potentiating loss of telomere integrity.Altogether, we foresee that this project will make a key contribution to our understanding of telomere dysfunction. Importantly, studying how spontaneous fusions arise and finding new c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'River flood Embankments Subject to Climate change: Understanding Effects of future floods and novel ‘low-carbon’ adaptation measures' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The RESCUE project will develop a state-of-the-art approach to assess the impact of future climate-induced floods on stability of existing river flood embankments, both locally and at a regional scale. The ‘local-scale’ approach will be validated against case studies made available by flood management agencies in UK, Italy, and Germany (Associated Partners). The regional-scale approach will be built upon hands-on learning resulting from the implementation of hazard maps for existing flood defence systems from Associated Partners. In line with the combat to climate change, RESCUE will therefore focus on the development of carbon-efficient adaptation measures.RESCUE will allow Dr Annarita Pozzato to shape an independent leading position in the management of flood defence systems in the context of climate change. She will be able to diversify her individual competencies by acquiring multi-disciplinary skills (stochastic hydrology, bio-engineering) and undertaking significant inter-sectoral experience through synergic collaboration with European public agencies. RESCUE will be instrumental in the creation of a European spin-out company, which is the career that Dr Pozzato is aiming to embrace. RESCUE will also give Dr Pozzato the chance of resuming her research career after a professional and maternity break.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INFINITY:  INfrastructure support and capacity building for the Future INternet communITY' (INFINITY) under Seventh Framework.

assistant: **Objectives**

The INFINITY Support Action will have a positive impact on the success of the FI-PPP programme. Through collaboration with organisations across Europe, INFINITY will capture and communicate information about available infrastructures and any interoperability requirements and issues. INFINITY will document any usage-related operational constraints and seek to identify and foster federation opportunities that could facilitate large scale experimentation and testing.A dynamic innovative repository based on a set of community-driven Web tools will be realized to promote the evolving vision of available infrastructures as a living organism". This is supported by a methodology that will promote a consistent categorisation of the infrastructure resources, thereby facilitating a mapping between Use Case requirements and infrastructure offerings.The efficient gathering of data about the available infrastructures is ensured by including key representatives of the important public and private infrastructure stakeholders directly in the consortium and/or as members of a "Concertation Board".The Web repository, the close co-operation with the FI-PPP Facilitation CSA and the specific expertise and relationships of the partners will:\tsupport the Core Platform by consolidating detail about existing and emerging advanced infrastructures, and help define the required Generic Enablers for seamless integration and enable new and innovative experimentation.\tstimulate infrastructure owners to effectively "bridge the gap" between their current capabilities and Use Case requirements, thereby encouraging investment in upgrades and standards to realise these opportunities, and leading to greater sustainability.The project will produce an evolving series of recommendations, roadmaps, tactical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A global initiative to understand gypsum ecosystem ecology' in the context of a Horizon 2020 call.

assistant: **Objectives**

Gypsum soils occur worldwide and represent natural laboratories of evolution and ecology. The unusual mineral content of gypsum soils is a significant barrier to the growth of most plants, and yet these soils host highly diverse endemic floras that have evolved independently on five continents. Nevertheless, these ecosystems are poorly understood compared to those of other unusual substrates. Little is known about the conservation status of gypsum floras, the potential impact of climate change on them, and their responses to mitigation and restoration. We propose an integrated global study of the ecology and evolution of plant and lichen life on gypsum, including eight gypsum-rich regions from four continents that differ in geological origin, climate, and flora. We will 1) assess the plant and lichen diversity of gypsum; 2) investigate the evolutionary origins and assembly of these floras; 3) evaluate potential adaptive mechanisms on gypsum, the functional structure of gypsum plant and lichen communities, and the processes regulating gypsum ecosystem function; 4) analyse the responses of gypsum communities to global change drivers and explore how gypsum ecosystem restoration/conservation may help mitigate the effects of global change; 5) promote the study of gypsum ecosystems; and 6) communicate the ecological and conservation value of these ecosystems to the public. With the involvement of gypsum experts from 18 academic and non-academic organizations from 11 countries, this project provides an innovative, integrative, and interdisciplinary approach to address key questions in gypsum ecosystem ecology, evolution, and management. The project thus strengthens existing international collaborative networks and consolidates Europe’s leadership in gypsum ecosystem research,