RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Understanding the speed limits of magnetism'.

assistant: **Objectives**

While the origin of magnetic order in condensed matter is in the exchange and spin-orbit interactions, with time scales in the subpicosecond ranges, it has been long believed that magnetism could only be manipulated at nanosecond rates, exploiting dipolar interactions with external magnetic fields. However, in the past decade researchers have been able to observe ultrafast magnetic dynamics at its intrinsic time scales without the need for magnetic fields, thus revolutionising the view on the speed limits of magnetism. Despite many achievements in ultrafast magnetism, the understanding of the fundamental physics that allows for the ultrafast dissipation of angular momentum is still only partial, hampered by the lack of experimental techniques suited to fully explore these phenomena. However, the recent appearance of two new types of coherent radiation, single-cycle THz pulses and x-rays generated at free electron lasers (FELs), has provided researchers access to a whole new set of capabilities to tackle this challenge. This proposal suggests using these techniques to achieve an encompassing view of ultrafast magnetic dynamics in metallic ferromagnets, via the following three research objectives: (a) to reveal  ultrafast dynamics driven by strong THz radiation in several magnetic systems using table-top femtosecond lasers; (b) to unravel the contribution of lattice dynamics to ultrafast demagnetization in different magnetic materials using the x-rays produced at FELs and (c) to directly image ultrafast spin currents by creating femtosecond movies with nanometre resolution. The proposed experiments are challenging and explore unchartered territories, but if successful, they will advance the understanding of the speed limits of magnetism, at the time scales of the exchange
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '7th Conference and Exhibition of the European Ceramic Society' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The Conference and exhibition of the European Ceramic Society - ECerS (Federation of 20 national ceramic societies from European member and Associated States) is organised every two year. It rotates from one country to another as the presidency of the Society. This event is the highlight of the ECerS members activities (field of ceramic materials) and is now recognised as one of the most important opportunities in the Ceramic and technology calendar in Europe and in the World. It is mainly a scientific event that gathers around 600 participants and in majority (about 80%) participants from universities and research institutes in Europe (member and Associated States). It represents a unique meeting opportunity for European scientists interested by ceramics. The broad topic of the conference is encompassing analyses of archeological ceramics, traditional ceramics, as well as advanced ceramics (either functional materials with special electrical, magnetic, thermal and optical properties for applications such as hardware for information and communication technology, electronics or materials for structural applications e.g. wear parts, high temperature components and coatings).The next event in the series will be organised in Belgium (Brugge) in September 2001 during 5 days and will offer to the participants the possibility to shortly present their work (orally or by poster), to attend invited lecturers (mostly key-note), speech and poster competition of young researchers, the different social events (welcome party and banquet) and the educational session, to visit the exhibition, to meet other European Scientists working in similar field and to see their contributions published in the registered proceedings of the Conference. The Conference proposes 15 scientific sub-sessio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Oncogene-Induced DNA Damage in Cancer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

I recently proposed a model that helps explain the presence of p53 mutations and genomic instability in human cancers (Nature, 2005; Nature 2006; Science 2008). The key features of this model are that oncogenes induce DNA replication stress, which in turn leads to DNA double-strand breaks, genomic instability and p53-induced senescence or apoptosis. This model is relevant for almost all cancer types and explains the spectrum of mutations being reported in thousands of human cancers by the cancer sequencing consortia.In this project, I propose to take the next logical steps that follow from my discovery. Specifically, I propose the following objectives:1. Elucidate the mechanisms by which oncogenes induce DNA replication stress. Oncogene-induced genomic deletions map within very large actively transcribed genes. Accordingly, I hypothesize that oncogenes and transcription synergistically disrupt pre-replicative complexes resulting in large genomic regions that have a low density of replication initiation events. To test this hypothesis, I propose to introduce by site-directed homologous recombination a transcription termination sequence at the beginning of very large gene and determine whether it remains sensitive to oncogene-induced genomic instability. Genome-wide transcription and DNA replication patterns will also be examined in cells that are sensitive to oncogene-induced DNA replication stress (most somatic cells and cell lines) and cells that are resistant (induced pluripotent stem cells).2. Identify and characterize genes necessary for proliferation of cells with oncogene-induced DNA replication stress. Using high throughput siRNA screens we will identify genes, whose depletion inhibits proliferation of cells with oncogene-induced DNA replication stress, without a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Copper-Catalyzed Multicomponent Reactions in Tandem Processes for Target Molecule Synthesis' under Horizon 2020.

assistant: **Concept**

The invention of processes that can form several bonds, stereocentres and rings in a single process is key to a sustainable future in synthetic chemistry. Multicomponent reactions and tandem procedures are two strategies that enable the rapid build-up of molecular complexity from simple reagents. By combining these two strategies into a single procedure, the diversity, complexity and value of products can be further enhanced along with the efficiency and economy of their construction. In this project, Dr Satpathi will develop novel copper-catalyzed multicomponent couplings of unsaturated hydrocarbons (e.g. allenes, enynes) with imines and boron reagents. These procedures will provide high-value amine products with universally high regio-, diastero- and enantiocontrol. The products will bear a variety of synthetic handles, for example, amino, alkynyl/alkenyl, and boryl groups, thus the products are primed for subsequent transformation. Dr Satpathi will exploit this functionality in tandem intramolecular couplings (e.g. intramolecular Suzuki/Buchwald-Hartwig reactions) to provide core cyclic structures of drug molecules and natural products. Thus, through a tandem procedure of; 1) copper-catalyzed borofunctionalization, and; 2) subsequent transition-metal catalyzed cyclization, he will gain efficient access to highly sought-after complex molecules. Overall, the process will provide high-value, chiral, cyclic motifs from abundant, achiral, linear substrates. Finally, Dr Satpathi has identified the phthalide-isoquinoline family of alkaloids as target molecules to display the power of his tandem methodology. Dr Satpathi has devised a novel route, which begins with our tandem multifunctionalization/cyclization reaction, to provide a range of these important alkaloids. The cho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'microRNA function in homeostatic plasticity in the mammalian brain' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Neural circuits are constantly modified in response to experience and changes in the environment, a phenomenon known as plasticity. While classical Hebbian plasticity is crucial to encode information, a different set of mechanisms, commonly referred to as homeostatic plasticity, are used by neurons to stabilize their activity in the face of perturbations that alter excitability. Homeostatic plasticity plays a critical role during activity-dependent development of neural circuits, and it is frequently distorted in common psychiatric disorders, including autism, mental retardation and schizophrenia. However, in contrast to Hebbian plasticity, the molecular underpinnings of homeostatic plasticity are largely unknown. We hypothesize that microRNAs (miRNAs), a recently discovered class of regulatory small non-coding RNAs, might have a prominent role in homeostatic plasticity by fine-tuning the expression of critical synaptic proteins. Using a large activity-regulated miRNA cluster as a paradigm, we plan to identify functionally important miRNAs during homeostatic plasticity in vitro and in vivo, to elucidate their mode of regulation and to determine the relevance of perturbed expression of these miRNAs for psychiatric disease. Towards these aims, we plan to use a battery of innovative approaches, including miRNA loss-of-function screening, biological target discovery, time-lapse fluorescence imaging of miRNA activity, genetic manipulation of mouse models of psychiatric disease and systemic brain delivery of miRNA mimics. This project has far reaching implications for our understanding of homeostatic mechanisms in brain development and disease, and could open up new avenues for the treatment of prominent psychiatric disorders that arise from defective neural homeostasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Clinical validation of retinal oximetry as a biomarker' under Horizon 2020.

assistant: **Concept**

Disturbance in oxygenation of the retina of the eye is believed to be involved in many sight-threatening diseases, such as diabetic retinopathy, glaucoma and age-related macular degeneration. Oxymap ehf (SME) has developed an oximeter to measure retinal oxygenation. The oximeter is already used by over 20 research groups and the results of small-scale studies indicate that the oximeter can measure disturbed oxygenation in various common and serious eye diseases.The Oxymap oximeter is currently only useable for research and the aim of the phase 1 and 2 projects is to validate oximetry for clinical use. This will allow earlier intervention and better monitoring of disease progress, benefiting individual patients. Due to the high prevalence and severity of the diseases, societal and economic gains are also considerable. Moving retinal oximetry from being a research tool only to being a validated clinical biomarker will also create a much larger market for Oxymap.The phase 1 project will yield a feasibility report, including a business plan. The project will lay the foundation for later uptake of retinal oximetry in clinical practise and the concurrent successful commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disrupting the cooling and heating industry: a revolutionary green, energy efficient and cost competitive magnetocaloric technology platform' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Magnetocaloric (MC) heat pumps can unlock sustainable heating and cooling by limiting GHG exhaust! So far, nobody has been able to create a commercially sustainable product due to high costs of rare-earth materials needed. Magneto’s technology has, based on our patented composition of MC material, for the first time ever, developed a heat pump using affordable and available non rare earth materials. Our heat pump will enable scalability to the most price sensitive markets: northern European countries with high energy costs, incoming regulation on GHG emissions, and an increased need of commercial cooling equipment due to urbanisation. With EIC support we will expand our current temperature span and run first pilots in commercial cooling sector by 2025. It will prove our product and business model, increase market attraction and improve our further fundraising position. We plan to reach breakeven by 2027 and a revenue of €85 million with a gross margin of 78% by 2029.


**Keywords:** commercial cooling,sustainability,gas free industrial heating,gas free buildings,COP,heat pumps,replacement of refrigerant gas,cooling and heating,magnetocaloric materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of novel diagnostic and therapeutic approaches to improve patient outcome in lung and pancreatic tumours' (CANCERALIA) under Seventh Framework.

assistant: **Objectives**

Lung and pancreatic cancers still have a mortality rate over 85% at 5 years of diagnosis, a clear demonstration of the actual treatment failure and the need for improved clinical management. This involves better tools for diagnosis, prognosis, and selection of sensitive and resistant patients to current conventional therapies or improved innovative treatments as well as the development of novel therapeutic strategies.The major objective of this proposal is to improve management of patients with either lung or pancreatic tumors by studying the clinical applications of still not investigated metabolic and signalling pathways with the following aims:-development of new tools for early diagnosis-identification of novel tumour markers for early diagnosis and prognosis-prediction of response to conventional treatments-identification of the molecular mechanisms of generation of resistance-development of improved treatments based on the identification of novel molecular targets-design of novel anticancer strategies.-achieve a better understanding of how combinatorial treatments using current standard clinical procedures with novel treatments under development may improve patient outcome.The proposed consortium is composed of four experimental research groups with a profound knowledge on molecular and cellular biology of cancer, and ample experience in the design of targeted and personalized cancer therapies along with translational research, complemented with three clinical groups with an extensive experience in the clinical management of lung and pancreatic cancer patients, guaranteeing a clinical proof-of principle and applicability, integrating basic-clinical European scientific excellence. Furthermore, the consortium has incorporated one company with direct involvement in c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Grammar of the Body: Revealing the Foundations of Compositionality in Human Language' (GRAMBY) under Seventh Framework.

assistant: **Objectives**

The pioneering framework I propose for the analysis of the foundations of human language – the Grammar of the Body – is inspired by sign language.  My main aim is to create a body-based model of linguistic compositionality and to provide clues of its evolutionary origins.Instead of analysing sign language (and language generally) from the perspective of mental categories, the radical approach I introduce here analyses language from the outside in, from the physical articulators of the face, hands, and body in sign language, to the grammatical structures they manifest.  This new approach capitalizes on the discovery that gestures of each articulator make a meaningful contribution to the whole corporeal display, and yield a hierarchy from small to large in both body and grammar domains: hands/words  >  head and face/phrasal intonation  >  torso/discourse perspective. I hypothesize that the corporeal base of compositionality has deeper evolutionary roots in the emotional face and body displays of humans and our closest living relatives, chimpanzees.The multi-disciplinary methodology I adopt will incorporate linguistic analysis of established and newly emerging sign languages with artistic manipulation of language form, and allow us to trace the origins of the system in emotional displays of both humans and apes.My central goal – determining the basis and structure of compositionality in human language – and the unconventional methodological approaches it exploits combine to make this an extremely ambitious proposal with potentially wide-reaching ramifications in the humanities and social sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A neuroprosthesis to restore the vagal-cardiac closed-loop connection after heart transplantation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With 3500 annual surgeries worldwide, heart transplantation is the last resort for an increasing number of patients affected by end-stage heart failure (HF). Heart transplant (HTx) can significantly increase life expectancy of HF patients but unfortunately exercise capacity and health-related quality of life of HTx recipients are still limited, due to the increased frequency of late complications mainly owing to chronotropic incompetence because of cardiac denervation. Orthotopic heart transplantation (OHT) is the most common approach of HTx, involving the complete explantation of the native heart, making surgical denervation inevitable. Therefore, the modulation of rate- and load-contractility relationship of the donor heart is significantly altered after transplantation even if using different surgical techniques. Addressing this fundamental clinical problem is the main goal of NeuHeart, that will be furthered by specifically investigating the physiology of denervated heart which will facilitate the development of a bioelectronic solution based on the closed-loop neuromodulation of the vagus nerve (VN), using a regenerative neural interface (for VN stimulation) and implanted artificial sensors (to record sensory information and close the loop). This cardiac smart neuroprosthesis will be tested in a swine model of OHT to demonstrate the feasibility of artificially re-establising vagal control in a denervated heart, by re-enabling the cardiac-vagal connection: the overall research output of the project will deliver multiple impacts, remarkably contributing to heart transplant science (fundamental research), help in the constitution of a new treatment paradigm for heart failure (clinics and society), and reach into the emerging industry of bioelectronic medicine (technol