RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Viral Vaccine Vectors in Personalized Medicine' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Melanoma and lymphoma are tumors that strike millions of people worldwide and require aggressive and expensive therapies. Numerous therapies are already being used or in the pipeline, yet all of them focus on the rapid elimination of the active neoplastic process. They do not provide options for long-term surveillance and deterrence of minimal residual disease, that is, of cancer relapse arising from the few tumor cells that survive the aggressive bout of therapy. Therefore, even patients considered cancer-free upon successful therapy are monitored over decades for potential relapses and condemned to a life of uncertainty. I propose to develop a novel class of versatile tumor vaccines for long-term surveillance of tumors based on a modified virus vector. Our modified viral vector combines an exceedingly safe profile with robust and long-lasting immunity.  Several developers have focused on human virus vaccine vectors that grow poorly in tissue culture, and as human pathogens, present iatrogenic concerns. Our modified viral vector system grows faster in animal cells than human counterparts, but cannot replicate in human cells. Therefore, our vector system is generally considered innocuous for humans. The replication in human cells is aborted at the early stage of infection, but immediate-early genes are expressed at robust levels, and thus may stimulate immune responses. Our modified viral vector system establishes latency and is maintained for life in the nuclei of infected cells, where they release low levels of antigen for the life of the host. Thus, it provides a depot of antigen that is slowly released over time and promotes the uniquely strong and sustained immunity. Our approach is unique in its design to provide long-term immune surveillance of tumor cells, and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhancing the capacity of EU transport projects to transform research results into innovative products and services', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The vision of the TIPS project is to produce better innovation in the transport sector by enhancing the capacity of EU-funded FP projects in the field of transport to be at the source of innovation and to help them transform research results into products and services.The transport sector is faced with major challenges. Demand in transport  will grow by 50% for passengers and 80% for freight (EU 2000–2030). At  the same time the call for energy savings, renewable resources and less  CO2 is putting pressure. Transport is a main factor for economic  sustainability and growth, but this sector needs to be pro-active to get  more innovative solutions quicker into the market. A lot of funding goes into transport RTD, but RTD results do not reach the market accordingly. What we need are good practices for  the different transport modes, to see which exploitation channels are working, where to find financing and first users and how to access new markets.Based on sound field work, TIPS will analyse successful exploitation in finished RTD projects and derive exploitation approaches and good practices. Highly innovative transport RTD projects will receive help to improve the capabilities to exploit R&D results in such a way that they gain competitive advantages and improved market shares.  Road, rail, maritime and air plus intermodal transport will be covered.The results from the field work and the experience from one-to-one assistance to highly innovative projects will be gathered in recommendations and best practice guidelines for transport RTD project partners.Experienced partners, both in field work and impact analysis as well as in innovation and exploitation strategies will collaborate in TIPS. TIPS ensures a good geographic coverage of the EU. With France, Germany and Italy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Alpha-Catenin regulatory properties and functions during Zebrafish development' to be submitted under Seventh Framework.

assistant: **Abstract**

Adherens junctions (AJ) play key roles in cell-cell adhesion, cell migration and cell signaling in a variety of biological processes. AJ are dynamic structures composed of cell-cell adhesion proteins (cadherin super-family), associated adaptor proteins (alpha-, and beta-catenin) and other proteins (p120) that locally regulate the actin cytoskeleton. The functions of two components of the AJ, cadherins and beta-catenin, are well understood, but the function of alpha-catenin is not. Significantly, Professor Nelson’s laboratory identified new functions for alpha-catenin that may be particularly important during cell rearrangements. An important, unanswered question is how these AJ are regulated during complex cell rearrangements when cell-cell contacts are maintained as cells migrate. We propose to combine classical zebrafish methodologies with cell biochemical and biophysical approaches, and high resolution live cell imaging to define mechanisms underlying epithelial cell rearrangements driven by remodeling and stabilization of AJ during different phases of zebrafish development. This project embodies a unique research plan for the candidate in which he will examine the dynamics of cell adhesion and migration in zebrafish embryogenesis by initially applying biochemical and cell biology strategies developed in Professor Nelson’s laboratory at Stanford University, and subsequently use biophysical, imaging and genetic methods developed in Dr. Gilmour’s laboratory at the EMBL. Zebrafish is an established model system for genetics and development biology, and is emerging as model for cell biology studies; this project proposes to push these boundaries further by using strategies developed from biochemical and biophysical studies. The overall aim of the project is, therefore, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engine Representative Internal Cooling Knowledge and Applications' (ERICKA).

assistant: **Innovation**

The goal of ERICKA is to directly contribute to reductions in aircraft engine fuel consumption with a targeted contribution of 1% reduction in SFC relative to engines currently in service.  The fuel efficiency of a jet engine used for aircraft propulsion is dependent on the performance of many key engine components.  One of the most important is the turbine whose efficiency has a large influence on the engine fuel consumption and hence its CO2 emissions. The turbine must operate with high efficiency in the most hostile environment in the engine.   The design of turbine cooling systems remains one of the most challenging processes in engine development. Modern high-pressure turbine cooling systems invariably combine internal convection cooling with external film cooling in complex flow systems whose individual features interact in complex ways.  The heat transfer and cooling processes active are at the limit of current understanding and engine designers rely heavily on empirical tools and engineering judgement to produce new designs.   ERICKA will provide a means of improving turbine blade cooling technology that will reduce turbine blade cooling mass-flow relative to that required using existing technology.  A reduction in cooling mass-flow leads directly to improved component and engine efficiency.  The improved technology for turbine cooling developed by ERICKA will also enable low NOx combustion chambers to be included in future engines.   ERICKA will undertake research to furnish better understanding of the complex flows used to internally cool rotating turbine blades. This will be achieved by:-  1) Acquisition of high quality experimental data using static and rotating test facilities 2) Development of cooling design capability by enhancement of computer codes that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Form and Function of the Mitochondrial Retrograde Response' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The molecular communication between mitochondria and nucleus is an integrated bi-directional crosstalk - anterograde (nucleus to mitochondria) and retrograde (mitochondria to nucleus) signalling pathways. The mitochondrial retrograde response (MRR) is driven by defective mitochondrial function, which increases cytosolic reactive oxygen species (ROS) and Ca2+. Metabolic reprogramming is a key feature in highly proliferative cells to meet the energy needs for rapid growth by generating substrates for cellular biogenesis. In these mitochondria retro-communicate with the nucleus to induce wide-ranging cytoprotective effects exploited to develop resistance against treatment and sustain uncontrolled growth. Recently, the mitochondrial management of cholesterol-derived intermediates for the synthesis of steroids has been demonstrated as a determinant in the oncogenic reprogramming of cellular environment. We hypothesise that cholesterol-enriched domains facilitate the communication between remodelled mitochondria and nucleus to expedite MRR. This mechanism may be exploited during abnormal cell growth in which cholesterol metabolism and associated molecules are increased.This application capitalizes on expertise in cell signalling and metabolism to interrogate core pathways and unveil molecular sensors and effectors that define form and function of the MRR by: I. Elucidating the mechanism of metabolic regulation of MRR, describing the role exerted by cholesterol trafficking; II. Unveiling microdomains for mito-nuclear communication established by remodelled, autophagy escaped, mitochondria;III. Validating protocols to modulate and target MRR for diagnostic and therapeutic benefit;The experimental plan will (i) define a molecular signalling axis that currently stands uncharacter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Ungovernable City: Interest Groups and Local Political Institutions in the United States and Europe'.

assistant: **Concept**

As nations in the developed world strive to reduce carbon dioxide emissions to counteract the effects of climate change, transitioning from more carbon intensive cities to greener modes of housing and transportation will become paramount challenges for governments throughout the 21st century. The United States, who produces about 11 percent of CO2 while accounting for just two percent of the world’s population, presents a particular challenge. Infrastructure costs in the United States are astronomically higher than in comparable developed nations in Europe or Asia. Further, housing construction—especially dense urban housing and its accompanying low carbon profile—is nearly impossible to build in almost all major American metro areas due to restrictive land use policies, an abundance of veto points exploited by engage local interest groups and America’s strong federalist institutions that give deference to local governments when deciding land use policy. This project seeks to understand how interest groups in the United States capture local housing and land use policymaking and why a similar phenomenon hasn’t evolved in many European Union nations. Studying local interest groups in a comparative setting will better illuminate how weaknesses in political institutions engender this behavior and lead to differing outcomes between the two regions. Identifying these institutional deficiencies will also aid reforms in the United States crucial for modernizing that democracy and aiding the global fight against climate change. This project will also deepen understanding of how interest groups form and evolve, what motivates the transition from individual financial motivation to the formation of an interest group and how these groups capture local political institutions.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Digital neuroanatomy in Squamates: from endocast to brain morphology'.

assistant: **Objectives**

In the absence of brain tissues preserved in the fossil record, vertebrate endocasts provide the only ‘direct’ evidence of brain evolution through deep time, and the possibility to infer cognitive and sensory abilities of extinct taxa. However, the validity of paleoneurological studies critically depends on the reliability of endocasts as a proxy for brain morphology. The variable brain-endocast correspondences found between and within modern vertebrate lineages prevent any generalizations to date. A detailed understanding of brain-endocast relationships in extant vertebrates is thus extremely important in order to avoid erroneous interpretations based on endocast morphology alone. NeuroSquam aims to study the brain-endocast relationships in the clade of Squamata, including lizards and snakes. Despite previous studies reporting a wide range of brain versus endocranial cavity proportions in lizards, our understanding of squamate brain-endocast relationships remains limited. By combining 3D imaging and 3D geometric morphometrics on a wide range of species, this research will provide a detailed and updated assessment of the brain-endocast relationships in Squamata. I will explore how these relationships vary between and within species in order to understand the different eco-biological factors that may impact the correspondence between brain and endocast. In addition, the comparison of morphometric data obtained from different 3D imaging techniques will provide new insights into the impact of fixation and staining on tissue shrinkage. By identifying reliable tissue-specific correction factors to adjust for shrinkage, this project will provide a starting point for future neuroanatomical studies seeking to use data from different imaging protocols. NeuroSquam’s originality a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nas- extension to contract No.nne-2000-450, Title Egcn Nas' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The solutions provided for efficient space heating, cooling, ventilation, lighting systems, domestic appliances, and integration of renewables into buildings, etc. are continuously being improved, however the improvements do not always reach full market effect why there is an urgent need to emphasise demonstration, dissemination and development of the latest technologies to both the supply and demand side of the market for sustainable urban housing. If the current level of information could be lifted into the mass market, obvious socio-economic gains are awaiting and a substantial amount of energy can be saved. Especially in NAS partner countries the is a great potential for technology transfer and substantial awareness lift as well as social and community gains for a new enlarged EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'From Chrysoloras’ Latin to Erasmus’ Greek: Renaissance classical bilingualism as a European phenomenon (1397-1536)'.

assistant: **Innovation**

ERASMOS hypothesizes that, in contrast to the tenet, the great age of Latin-Greek bilingualism, especially in its written form, is not to be situated in antiquity. Instead, classical bilingualism flourished in the Renaissance, a pivotal period in canonizing classics. After 1397, when M. Chrysoloras started teaching Greek in Florence, classical bilingualism developed into an authorial ideal championed by writers like Erasmus (d.1536). This ideal pervaded countless genres, far beyond classical standards. It turned into a common practice shaping Europe’s cultural identities across the Republic of Letters, where Latin-Greek code-switching occurred on a daily basis.ERASMOS opens a new research avenue on Renaissance classical bilingualism in its own right, which offers broader opportunities. The project has 3 main aims. (1) It inventories classical bilingual sources from the long 15th century (1397–1536) in a database, in order to create a new detailed heatmap of European humanism. (2) It develops digital tools for the analysis of literary multilingualism, leading to a new form of digital humanities-assisted close-reading. Most notably, the novel “tongueprint” tool will allow us to automatically calculate the linguistic make-up of texts. This tongueprint aims to further integrate multilingualism into Neo-Latin studies by cross-fertilizing the field with historical sociolinguistics. (3) ERASMOS analyzes through DH-assisted close-reading the forms and functions of classical bilingualism, in comparison to its ancient pendant, thus testing the core project hypothesis.ERASMOS, in sum, brings cultural-historical and digital-conceptual innovation. The tools developed will benefit humanities studies more broadly and will help us save a key part of European cultural history from obliv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unsteady High-Lift Aerodynamics – Unsteady RANS Validation' to be submitted under Horizon 2020.

assistant: **Abstract**

UHURA aims at validating unsteady numerical simulations of the aerodynamics of high-lift systems during deployment and retraction. In detail we perform:- Validation of numerical simulation methods for prediction of the unsteady aerodynamics and dynamic loads during the deployment and retraction phase of high-lift systems. We expect to verify the ability of predicting the unsteady aerodynamics and corresponding loads on the Krueger flap within an accuracy comparable to steady state calculations (less than 1% error in lift, drag and pitching moment).- Quantification of the completely unknown aerodynamic characteristics of a slotted Krueger device during deployment and retraction. We expect to quantify the difference of the actual unsteady loads to the values obtained by state-of-the-art approaches to estimate the critical loads, which are either steady-state predictions or handbook estimations. And, we expect to achieve a system complexity reduction of about 70% by verifying the conceptual feasibility of a central drive architecture for a Krueger flap by properly assessing the handling qualities impact during the deployment. We also expect by this to keep the system weight at or below levels of current state-of-the-art slat devices. Further on, the higher accuracy for load calculations shall reduce the necessary safety margin for the structural sizing due to better knowledge of the actual loads. - Qualification of impact on handling qualities and certification. We expect the Research and Innovation Action to qualify the impact of the unsteady aerodynamic and of the dynamic loads during deployment on the handling qualities and certification issues. The latter also addresses the risk anand mitigation of failure cases.


**Keywords:** fixed keywords: IDV, ASE, NUM, FLP, aero