RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Safety and efficacy for new techniques and imaging using new equipment to support European legislation.' (SENTINEL).

assistant: **Concept**

Health services in the EU are a growing fraction of national wealth, typically 10% of GDP. Within this radiological imaging is gaining increasing prominence and now accounts for up to 10% of hospital revenue and 15% of capital equipment budgets, thereby identifying it as an investment of major social importance.This increase has been driven by new developments in equipment, digital imaging, medical devices, and IT industries; paralleled by novel clinical practices and modalities. Striking examples include the introduction of digital technologies to replace film, and the range of sophisticated angiographic techniques now used widely.This proposal deals with radiation protection, safety, and related issues that arise from these developments. It covers over 90% of patient examinations, 60% of the collective dose from medical sources, and approximately 50% of the collective dose from man-made sources.In practice this proposal deals with almost all radiological digital imaging outside of CT Scanning.This proposal is essential, as at present development is entirely driven by the combined and essentially global forces of the industry on one side, and the clinical users on the other.There has been no parallel investment in research on the protection, safety, efficacy, optimisation, justification, and ethical issues (despite a certain amount of regulatory development).This deficit is now evident, as day-to-day practice has outpaced the available statutory safety and standards framework. Undertaking the proposed programme, which spans: Functional and Objective Equipment Performance and International Standards Dosimetry,Constancy Testing and QA Justification,Ethics, and Efficacy Guidelines, Good Practice, and Training Materials will underwrite the safety, efficacy and ethical aspe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deconstructing the stem cell niche in human interfollicular epidermis in vitro' to be submitted under Seventh Framework.

assistant: **Abstract**

Within adult tissues, stem cell properties are heavily influenced by their microenvironment, or niche. In the niche, stem cells integrate a complex array of extrinsic molecular signals that, in concert with cell-intrinsic regulatory networks, control self-renewal and differentiation in response to physiologic demands. By studying adult human epidermal stem cells ex vivo using artificial microenvironments (micro-patterned adhesive islands and hydrogels of differing bulk stiffness) we will investigate two questions: (1) What is the importance of intercellular adhesion in regulating epidermal stem cell fate? (2) How does the genetic state of a stem cell affect its responses to extrinsic signals? Combining state-of-the-art methodologies in biomaterials science and cell biology we will address whether cell-cell and cell-substrate signals have synergistic or antagonist effects on stem cell fate decisions, and whether one type of signal can over-ride another. Specific cell adhesion receptors will be engaged by recombinant proteins bound to latex beads, while specific cell-cell contacts will be engineered via avidin-biotin interaction. We will also investigate how intrinsic modulation of the Notch and Wnt signaling pathways changes epidermal stem cell responses to different niche signals of substrate contact area, substrate porosity and the engagement of specific intercellular adhesion receptors. The proposed project will be carried out at the Centre for Stem Cells & Regenerative Medicine, one of Europe's newest hot spots for stem cell research, based at King's College London, with Prof. Fiona Watt, a world expert in somatic stem cells, as scientist in charge. In such ideal surroundings, the fellow will be able to stimulate and advance European stem cell research, to significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Acoustic and Thermal Retrofit of Office Building Stock in EU'.

assistant: **Concept**

The objective of ActaReBuild is to provide high-level training of Doctoral Candidates in retrofit of office building stock in Europe by means a new generation of sustainable materials and building components. In particular, they will learn how to improve and guarantee acoustic and thermal performance of buildings that undergo renovation processes, while minimizing the embodied carbon production. The training offered to 10 Doctoral Candidates (DCs) interconnected through the network will enforce their research and transferable skills necessary for thriving careers in this burgeoning area. This goal will be achieved by a unique, interdisciplinary combination of specialized “hands-on” research training supported by high quality joint PhD degree supervision; by performing of secondments at industrial partners; participation at courses and workshops on scientific and complementary “soft” skills facilitated by the academic and non-academic partners of the consortium.Thanks to network-wide interactions, DCs will get acquainted with a variety of novel building materials and solutions (bio-, nano-, meta-, recycled, 3D printed materials and multilayer structural skins), measurement techniques and assessment methods (such as life cycle analysis and sustainability assessment, psychoacoustic methods, specialized thermal behaviour experiments and a variety of simulation techniques in acoustics, energy, hygrothermal behaviour). Their interaction with industrial partners within the consortium and, via outreach activities, to stakeholders in industry and society in general will promote the uptake of the resulting innovations beyond the network and accelerate their implementation for sustainable retrofits, thus maximizing the impact of the project.


**Keywords:** building retrofit, ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bridging the evolutionary gap between unicellular endosymbiotic cyanobacteria and organelles' (UCYNELLE).

assistant: **Concept**

Symbiosis has been key to evolution on Earth. The success of eukaryotes was possible due to the establishment of endosymbiotic relationships between unicellular microorganisms that gave rise to specialized organelles (chloroplasts and mitochondria), yet the mechanisms underpinning such biological innovations are still unresolved. An unusual marine nitrogen-fixing symbiosis involving a cyanobacterium called UCYN-A and a single-celled haptophyte algae (Braarudosphaera bigelowii) was recently found to have undergone genome rearrangements analogous to organelle evolution. Since no eukaryotes fix nitrogen (N2), an essential nutrient for life, knowledge on this peculiar symbiosis may serve as a unique opportunity for understanding the acquisition of new organelle-derived functions in eukaryotes. The UCYNELLE project is designed to provide new insights on organelle evolution through the multidisciplinary study of the UCYN-A symbiosis from an ecological, evolutionary and metabolic perspective: First, experimental manipulations with the UCYN-A culture and field surveys will be conducted to identify the molecular basis regulating the metabolic coupling between symbiotic partners and the associated microbiome. Second, the organelle genomes of the haptophyte host will be compared to those of the different UCYN-A lineages via comparative genomics to explore any parallelisms in their mode of evolution. Finally, the natural variation in cell size shown by UCYN-A and its host across different UCYN-A symbioses will allow investigating the metabolic scaling (metabolic rates vs cell size) of the N2 fixation process compared to that of typical organelle-driven metabolisms (photosynthesis and respiration) through the study of the volumetric relationships between chloroplasts, mitochondria,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Traces in the bones: reconstructing the lost soft anatomy of the earliest vertebrates through ultra-high resolution synchrotron scanning' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Early vertebrate evolution involved a series of drastic structural reorganisations as new features were added and elaborated. The fossil record illuminates this evolutionary history more directly than inferences from the diversity of living forms, but the fossils usually consist only of bones whereas many of the most important and interesting changes occurred in the soft anatomy. Traditional approaches to reconstructing the musculature and other soft tissues of fossil vertebrates rely on subjective tools, like the visual identification of rough bone textures thought to indicate muscle attachments, and generally leave a lot to be desired. Here I propose a wholly novel and radically more objective approach to the identification of soft-tissue contacts, using holotomographic synchrotron CT at sub-micron resolutions to identify these contacts by the three-dimensional micro-architecture of the bone. A pilot study has already shown that such scans (performed at the ESRF synchrotron facility in Grenoble) are capable of imaging key features such as arrested growth surfaces and probable Sharpey s fibres in 380 million year old fossils. We will undertake a systematic review of the three-dimensional bone micro-architectures associated with different soft-tissue contacts in living vertebrates, and the use this as a key to reconstruct the soft-tissue contacts on fossil bones with unprecedented accuracy. This will permit us to produce far more reliable reconstructions of the soft anatomy than has hitherto been possible. Our findings will inform other areas of palaentology, particularly functional morphology, and will also be of great importance to evolutionary developmental biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of p110beta isoform of PI 3-kinase in endothelial cells and angiogenesis' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference. Mammals have multiple PI3K isoforms. Here, I seek to investigate the role of the p110beta PI3K isoform in endothelial cells and angiogenesis, the growth of new blood vessels.The functions and activities of endothelial cells depend on input from growth factors, chemokines and adhesion molecules. All of these agents are known to signal through PI3K. Indeed, there i s evidence for a role for PI3K activity in angiogenesis, but the roles of the distinct PI3K isoforms in this phenomenon are unknown.Thus, I propose to investigate the role of the p110beta PI3K isoform in angiogenesis. I will use new PI3K mutant mice with a constitutively or conditionally inactive p110beta, which the Host Group has created (unpublished), and derived endothelial cells. At present, the physiological role of p110beta is completely unknown, and this PI3K isoform is one of the most enigmatic to d ate.The Host Group has found that p110beta expression is highly enriched in endothelial cells, providing a strong indication of its role in this cell type. Other than work in vivo, the proposed work will also cover detailed mechanistic investigations at t he cellular level in isolated endothelial cells, complemented by the use of isoform-selective PI3K inhibitors developed with Host Group collaborations.This post-doctoral period will allow me to be familiarized with advanced and unique approaches used by t he Host Group, including gene-targeted mice and sophisticated cell biology.Other than widening my scientific horizon and allowing me to establish international contacts, this project will also widen my expertise in basic research to the field of angiogenesis in w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanoporous Materials and Supramolecular Clusters for Light Induced Electronic Switches' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Molecular framework materials recently have been shown to possess immensely rich host-guest chemistry; their porous lattices are capable of highly selective host-guest properties that include reversible guest and ion exchange, heterogeneous catalysis, and gas storage and separation. It was realized that by further exploitation of the porous nature of metal-organic frameworks in combination with spin crossover centres, molecular sensing materials can be generated, whereby the spin crossover sites can be switched ‘on’, ‘off’ or altered by the presence, absence or exchange of solvent guest molecules. The challenge in this exciting new area is to generate such materials with a focus on real and timely application.  Light is one of the most promising ways to reversibly direct and control the physical properties of organic and inorganic materials. Spin crossover materials are a convenient class of compounds to make this possible as they are known to exhibit a light induced transition from a low spin to metastable high spin state, and indeed can show infinite lifetimes of the high spin state under certain conditions.  The overall object of this proposal is to develop inorganic nanoporous materials and supramolecular clusters which have inbuilt light initiated switches, in the form of iron(II) spin crossover centers, for use as optical switches and storage devices, molecular sensors, chemical detectors, drug delivery, data storage, displays and other electron devices. The project makes use of the complementary skills and expertise of the research groups in Bordeaux, Melbourne and Sydney to achieve the first detailed investigations of this novel co-existence of spin crossover and nanoporous materials towards ‘nano-scale’ light initiated switching applications. The impact of even
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated inspection for sintered parts by non-destructive techniques for improved quality in production' in the context of a Seventh Framework call.

assistant: **Objectives**

Sintered parts obtained by the powder metallurgy process are employed in several industry sectors, especially automotive. They are typically intricate, complex shaped parts produced in near net shape by compaction of powders into a geometry followed by sintering of the compacts for consolidation, where particles are bonded upon heating. The powder metallurgy process, by nature, is suited to high volume production and therefore any flaws/defects in the parts can have a significant impact on the production output for example loss of material and efficiency, as well as potential failures in use later. Therefore there is a need for automated inspection by non-destructive means, for determining and separating the good and bad batches during production, preferably as early as possible, without having to seek destructive examination carried out manually, which can have a negative impact on the production flow and output. More critically, any faulty part that is overlooked may cause more problems later on such as unexpected premature failures in application. Depending on the component and the criticality of the application this can have drastic consequences such as accidents.In this project, we will develop a digital radiographic system for online inspection of powder metallurgy parts. This technique allows fast inspection and application of image processing for the detection of small cracks, flaws and density variations in-situ.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Utopian Intentions: Critical Theory, Intentional Communities, and a Politics of Limits' (2014-2020).

assistant: **Concept**

Utop\Intent is a multifaceted research project that advances an original method of political and legal theory research which combines both rigorous theoretical analysis of canonical texts and ethnographic research. Its ambitious goal is both to develop a robust, adaptable model for the theoretical-empirical study of politics in the mid-21st century and rehabilitate the concepts of utopia and limits for contemporary progressive and egalitarian politics in an era that is increasingly marked by political malaise. It achieves this goal as the first book-length study to bridge the theoretical orientation of Critical Theory and Utopian Studies with the empirical orientation of Communal Studies using methods from Grounded Theory and Extended Case Method. Although these primary goals are scientific and aimed at career development, essential qualitative methods training, ERC grant-writing supervision, and networking oriented to obtaining a permanent research position in the EU, the project is also strategically positioned to concretely impact public policymakers, fair housing and community development social activists, and alternative higher education models through its open-access website and innovative higher education courses in collaboration with ULEI and Tamera Peace Research and Educational Center (Portugal).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthesis and biological evaluation of oligosaccharides of immunological importance in Cryptococcus neoformans' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Cryptococcus neoformans is an opportunistic human pathogen causing a life-threatening form of meningitis in immunocompromised individuals, especially in AIDS patients.The capsular polysaccharide is this yeast's main virulence factor. It allows the yeast to cross the hemato-encephalitis barrier and subsequently disseminate in the central nervous system. Some of the antibodies, specific for the major component of the capsule, a glucuronoxylomannan (GXM) polysaccharide, are protective against infection.However, knowledge of the exact nature of the repeating units of GXM associated to the various serotypes of C. neoformans and a fortiori that of the corresponding 'protective' epitopes is lacking. Using synthetic oligosaccharides made 'in demand', our goal is to fill these crucial gaps. Indeed 'protective' carbohydrate epitopes may be used both as prognostic tools as well as key components in the development of an efficacious GXM-derived conjugate vaccine.Besides, the GXM structure necessary and/or sufficient f or crossing the blood brain barrier might be identified. The originality of our project is the key in-house interactive partnership between genetics and chemistry. Using state-of-the-art glycochemistry, focus will be on the development of highly reactive convergent synthetic strategies. A set of key versatile mono- and disaccharide building blocks, optimized for target diversity and whenever possible compatible with solid phase synthesis, will be designed.Their appropriate combination will next lead to the oligosaccharide targets, selected according to hypotheses derived from screening for the biological properties of a large panel of randomly mutated strains. The Marie Curie fellow will be in charge of the synthesis and biological evaluation of the targets, including