RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Solar power exploitation by collection and transportation by fibre optics to remote utilisation modules'.

assistant: **Objectives**

SPECTRUM research concerns an innovative system to efficiently capture by means of modular optical collectors the solar energy and transport it by means of low loss broad band Fibre Optic cable to remote load or utilisation modules. These modules will convert the energy to heat, cool and electricity, either directly or trough a storage. Unadulterated sun light can be used for health treatment or natural illumination. The total SPECTRUM system efficiency can be high as compared to present conventional systems, because the available sun power can be shared, by means of a fibre switch, among different conversion modules making it possible to time share and utilise all the collected energy. SPECTRUM system will favourably extend the present and well established use of Renewable Energy (RE) solar plant because of its installation simplicity, lightweight non dissipating optical collectors, thin and flexible fibre cables and multipurpose utilisation modules with power sharing. Although a Proof of Concept laboratory model can be assembled with existing low performance components, SPECTRUM research is necessary to develop a valid full performance demonstrator, pre-engineering model, for which several conceptually new components, need to be developed. This demonstrator is required for the SPECTRUM industrialisation and should be capable to reach the expected targets of efficiency, flexibility of use and cost. A wide range of applications can be foreseen for this RE system which will integrate harmonically with urban architecture and rural landscape. SPECTRUM project, a two and half year research program, will be undertaken by a well balanced European scientific and industrial team across the community North to South axis. It is expected that the subsequent industrialisation phase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The International Politics of Law-enforcement Cooperation' (IPLEC).

assistant: **Concept**

The proposal includes three studies in the field of international relations. These studies examine the political dimensions of international cooperation in law enforcement. Study 1 explores why states succeed or fail to cooperate against smuggling along a shared border. The goal is to explain why Jordan has cooperated with Israel in combating smugglers of goods and persons, whereas Egypt has been less cooperative. Based on fieldwork in the Israel-Egypt and Israel-Jordan border areas, the study links governments' domestic political concerns to their efforts against smuggling. Study 2 examines the Israeli efforts against intellectual property piracy of American and European goods. Based on fieldwork in Israel, this study explains why Israel's enforcement of intellectual property rights is ineffective. Study 3 examines international cooperation among courts in combating parental child-abduction. This study explains the origin and evolution of the unique international regime that tackles child abduction. The study also explains why many countries have been reluctant to join this regime. The study involves fieldwork in Europe and the United States as well as interviews with judges at international judicial conferences. The three studies advance the analysis of the politics of law enforcement within the field of international relations. These studies also offer important insights for policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Implementing short-term prediction at utilities'.

assistant: **Objectives**

Objectives  This project aims to predict the power produced from  grid-connected wind farms by using meteorological  forecasting and to implement this prediction at  electrical utilities. The time-frame is from 0 to 36  hours ahead. This is done by extending and applying the  results of the JOULE project (``Short-term prediction of  local wind conditions'') and of two ongoing Danish  projects (JOULE 2: ``Wind Power Prediction Tool in  Central Dispatch Centres'', and EFP (Energy Research  Program): ``Using Meteorological Predictions'').  The main goal is to develop the models to such an extent  that it can be demonstrated that any utility with a  certain amount of installed wind energy capacity can use  the models with economic benefits.  A further goal is to show that these methods and  techniques developed in Europe can be used world-wide and  thereby create opportunities for the EU wind power  industry.  In the project four areas have been chosen: Denmark;  England, Scotland and Wales; Greece (Crete); and Texas in  the USA.  Technical Approach  Work will be performed by using prediction models based  on the forecast output from Numerical Weather Prediction  (NWP) models. In the present project the HIRLAM model of  the Danish Meteorological Institute will be used. This  is an operational model generating forecasts 36 hours  ahead, twice a day. The output of this model is then  made valid locally by one of two methods: a physical  model where the local effects are corrected for by the  WAsP program and the production of the wind farm is  calculated taking the shadowing of wind turbines into  account by using the PARK program. The other method is a  statistical one, where the statistical relationships  between the historical observations, the output from the  NWP model a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Scientific High-throughput and Unified Toolkit for Trace analysis by forensic Laboratories in Europe', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Transfer traces analysis currently suffers from several limitations: highly subjective and selective, this process is also very time-consuming, hence inefficient, whereas  results are difficult, if not impossible, to compare and share among forensic laboratories. As a consequence, the use of forensic data in cross-border investigations, and in foreign courts is limited. Creating a unified transfer traces automated analysis toolkit would allow for a higher productivity of forensic workers, better crime resolution and enable further collaboration across end-users. In addition to the lack of maturity of its potential components, the economical question is the barrier that hinders the development of such a toolkit as a sole forensic service can’t afford funding the corresponding R&D activities. the SHUTTLE project then intends to run a Pre-Commercial Procurement (PCP) action between forensic institutes across Europe to mitigate these technical and financial barriers and jointly carry out the procurement of the necessary Research and Development (R&D) activities to develop a machine+toolkit that will integrate different tape analysis tools to automate the routine part of the work of trace evidence examiners and, eventually, strengthen further judicial and police cooperation.The SHUTTLE toolkit will be scientific, as the results obtained will be objective and validated, which will strengthen their usefulness and usability. It will be high-throughput, as the instrumentation will be built to process large amounts of samples and data. The acquired data will be stored in a database together with the results of other methods. These databases can be shared  and maintained together, and be used to provide a scientifically justified, numerical evidential value.Finally, SHUTTLE, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of the histone variant H3.3 in epigenetic reprogramming of primordial germ cells' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The germ cell lineage gives rise to the gametes, which ensures the transmission of genetic and epigenetic information to the subsequent generation. In mice, the foundation of the germ cell lineage is based on the specification of primordial germ cells (PGCs) during embryonic development. Following specification, PGCs are epigenetically reprogrammed by active DNA demethylation and chromatin remodelling resetting the epigenome for acquiring totipotency. However, the underlying mechanisms of PGC reprogramming are not well understood. Recent studies point towards a role for the histone variant H3.3 as a central mediator of epigenetic reprogramming of PGCs. Most notably, the histone chaperone HIRA, which is necessary for the deposition of H3.3 into nucleosomes, is highly enriched in nascent PGCs. The proposed study aims to elucidate mechanisms of epigenetic reprogramming and its role in the establishment of the pluripotent state. Therefore, I aim to study the role of the key histone variant H3.3 and its regulation by the histone chaperone HIRA in PGCs by generating knockout mice models. Further, to gain new insight into the establishment of the unique chromatin signature in PGCs, I will monitor fluorescently labelled H3.3 in PGCs by time-lapse confocal microscopy. This will not only provide significant insight into the nucleosome dynamics of H3.3 but will also for the first time capture epigenetic reprogramming of PGCs in real-time.During my postdoctoral studies I will not only expand my background in cell fate specification and epigenetics in C. elegans and Drosophila towards a vertebrate model but will also establish novel in vivo imaging techniques in an excellent scientific environment. This project provides training in techniques of germ cell and stem cell biology and o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PROSME-INN - Improving RO3 SMEs management of innovation' (PROSME-INN) under Horizon 2020.

assistant: **Objectives**

PROSME services in RO3 region regarding SME Instrument support will ensure the delivery of “Key AccountManagement” (KAM) support services, enhance innovation management capacity and processes of SMEs, develop and testPROSME partners capacities for consultancy services.


**Keywords:** SME, innovation management, KAM, EEN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Inclusive Design and Intelligent Technology for Accessible Workplace' to be submitted under Fifth Framework.

assistant: **Abstract**

In the knowledge-based economy the workplace is anywhere: regardless of the individual location when intellectual work is underway. By including information and communication technologies on the premises one can describe the workplace as an intelligent" workplace.The IDIA Network aims at integrating the potential of the intelligent workplace with the principle of Design for All, and thus develop a new concept for workplace design - moving the current mindset away from the "individual" thinking, that tends to alter basic designs, towards including from the outset the maximum number of naturally diverse human beings in the design and planning process.The IDIA Network will establish a multidisciplinary project team, coordinated by the IDIA Scientific Committee that will carry out interdisciplinary analysis and studies for identifying user needs for the design of an accessible workplace, assessment of current and future technologies, and derive a collection of reference scenariosThe IDIA Network will produce a number of exploitable results:- Guidelines and prospective scenarios related to the uptake of a Europe-wide market for the production of new design components for accessible workplaces.- A community of actors supporting IDIA-compliant design concepts, that will continue to contribute ideas and results after the project end."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REVEALING THE MECHANISMS LINKING GENOME REPLICATION  AND EPIGENOME MAINTENANCE' (REGEM).

assistant: **Innovation**

DNA replication is essential for transmitting genetic information across cell divisions. Beyond DNA duplication, eukaryotic DNA replication forks must coordinate diverse processes necessary for the genome integrity maintenance, preservation of chromatin structure, and inheritance of epigenetic information contained within chromatin. DNA replication forks must perform these diverse tasks in real-time across various chromatin states and physiological conditions. To achieve coordination of these processes, many factors play pleiotropic roles, simultaneously regulating DNA synthesis with epigenome maintenance. Furthermore, the leading and lagging strands of the fork are replicated by distinct molecular machineries. This DNA replication asymmetry imposes significant mechanistic constraints, and genome and epigenome maintenance must adapt to it. The two strands exhibit differences in mutation rates, DNA damage repair, the mechanisms of maintenance of epigenetic marks, and silencing of transposable elements. The lagging strand may contribute to (epi)genetic instability under pathological conditions, yet the underlying mechanisms remain largely unknown. Our goal is to reveal new mechanisms linking DNA replication, fork stability, and chromatin maintenance, ensuring accurate duplication of all layers of chromosomal information. Our specific aims are as follows:(1) Reveal how the accurate genome replication coordinates with transposable element silencing.(2) Investigate how epigenome maintenance factors coordinate at replication forks to ensure accurate replication of genetic and epigenetic information across chromosomes.(3) Systematically dissect how are chromatin maintenance mechanisms linked to the leading and lagging strand replication and identify novel factors with dual rol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Understanding nervous mechanisms of cardioprotection to save the ischaemic and failing hearts'.

assistant: **Concept**

This project is designed to use the latest advances in molecular biology and neuroscience to determine the role played by the nervous mechanisms in the development of cardiovascular pathology. The project spans across distinct research fields of myocardial ischaemia/reperfusion injury, innate cardioprotective mechanisms and fundamental neuroscience and includes newly developed transgenic mice models and latest advances in viral gene transfer technology, pharmaco- and optogenetics for selective manipulation of parasympathetic or sympathetic efferent outflows to the heart. These novel genetic models offer unprecedented resolution and specificity and will be used to determine the role played by the autonomic nervous system in modulation of the myocardial ischaemia/reperfusion injury and progression of chronic heart failure. Another important part of this study will determine the involvement of neural pathways in powerful innate mechanisms of cardioprotection underlying the (pre)conditioning phenomena. The results of the proposed experiments are expected to have an instant translational potential and may lead to the development of novel therapeutic strategies which recruit innate neural mechanisms of cardioprotection to limit myocardial injury and improve quality of life of individuals suffering from heart disease. RESCUE THE HEART project includes an intense program of research and training to be undertaken by the experienced researcher and will ultimately promote effective transfer of research expertise, new technologies and research philosophy across wider European research base.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Comparative Study And Mechanisms Of Calcification Heterogeneity In Atherosclerotic Plaques' (CALTHERO), addressing dissemination and exploitation.

assistant: **Impact**

Arterial calcifications, like those seen in patients with atherosclerosis, contribute to morbidity and are predictors of premature death. Despite exposure to the same cardiovascular risk factors, previous studies have demonstrated the concept of the heterogeneity of atheroma according to the arterial beds. These differences have a major clinical impact on the occurrence of cardiovascular events (embolism, thrombosis, dissection, restenosis), and recurrence of the disease. The host laboratory recently showed that plaque heterogeneity was notably associated with a difference in calcification burden. Further classification distinguished amorphous from cartilage or even bone structures in the affected vasculature. This process remains poorly understood.This project aims to identify cellular and molecular mechanisms involved in the arterial calcification heterogeneity, by first fully characterizing the lesions in various vascular beds and by associating specific features of the plaque with calcification content. I will also test in vitro the contribution of endothelial cells (EC) and pericytes in vascular cells mineralization and calcification. In particular, I will assess the ability of EC and pericytes to alter macrophage and smooth muscle cell differentiation towards an osteoblast-like cell phenotype. The role of specific molecular pathways (RANK/RANL/OPG...) will be also tested functionally. To further analyze this process in vivo, I will generate double KO mice developing accelerated calcification in lesions and use in vivo fluorescence imaging to monitor plaque formation and calcification over time. Finally, I will assess the predictive clinical impact of the nature of the plaque on intra-stent restenosis in patients following OCT and serial duplex ultrasound imaging.A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Optimized Tool Path Generation Methods for Economic and Collision free Multi-Axis Machining'.

assistant: **Objectives**

The generation and the proving of the NC programs for multi axis milling operations remain in many companies a bottle neck that often prevents them to utilise the full capacity of their multi axis machines. As a result, manufacturing industries using multi axis milling machines have a strong need for better CAM and NC programming systems allowing a fast and optimal generation of NC data. In order to avoid expensive machine test runs, the NC program has to be error free and checked against collisions between machine, tool and part. The project objective is the integration of the CAM module (tool path generation), the post processing and the NC simulation. This will allow an immediate verification of each cutter location generated by the CAM module and the postprocessor. Dependent on the type of collision the simulation program detects, the postprocessor and/or CAM module will immediately take the appropriate action. This is not a simple warning to the operator, but a change of for example clamping position, the insertion of a clearance point into the tool path or a more complex collision avoidance method. New milling strategies such as in process tool orientation optimisation of which prototypes has been developed by the K.U.Leuven will be integrated in order to obtain better product quality, shorter machining times and collision avoidance possibilities. The integrated system will allow to have a higher process and product quality, a reduced workpreparation time and higher productivity up to 300% for single part production and more flexible use of for example external available NC machines. As a result of this project, end users expect to replace most of the manual operations by multi axis milling, having social and environmental benefits such as:  cleaner production (mi