RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metagenome and Bariatric Surgery - New Avenues to Treat Metabolic Disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Obesity and associated metabolic diseases such as type 2 diabetes are increasing worldwide and are the result of complex gene-environment interactions. Recent studies indicate that socio-demographic and environmental factors are more important for disease development than genetics, and we and others have demonstrated that the gut microbiota can be considered an environmental factor that contributes to obesity. Effective treatment for obesity remains a challenge and bariatric surgery is the only available therapy that is proven to maintain weight loss. Intriguingly, bariatric surgery also improves glucose metabolism, but the underlying molecular mechanisms for this beneficial effect are unclear. An altered gut microbiota has been linked to metabolic diseases and pilot studies indicate that the gut microbiota is also altered upon bariatric surgery; these findings suggest that some of the improved metabolic features following bariatric surgery may be mediated by altered composition of the gut microbiota. The overall goal of this proposal is to integrate clinical research with mechanistic studies in mice to determine if and how the gut microbiota mediates the beneficial effects of bariatric surgery. We will define how bariatric surgery alters the gut metagenome in humans, both at a species and at a functional level. By transferring the fecal microbiota from these patients before and after surgery to germ-free mice, we will determine if an altered gut microbiota directly modulates host metabolism. Finally, we will establish surgical methods in germ-free mice to directly test whether the beneficial effects observed following surgery require a microbiota. Increased understanding of these mechanisms may provide the basis for non-surgical treatments based on supplementation of n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Investigating the Molecular identity of PAcemaker neurons in CorTical development'.

assistant: **Objectives**

Spontaneous activity is a prominent feature of the immature brain. Even before birth and in absence of stimuli, neurons organize in networks and spontaneously generate correlated activity. While spontaneous dynamics in the cerebral cortex have long been overlooked and considered just as epiphenomena, recent clinical data on preterm infants and preclinical studies have spurred a renewed interest for this early electrical activity. However, appreciation of the role of spontaneous activity during the perinatal stages remains elusive. Indeed, it is still unknown how spontaneous patterns arise, and whether, among the large variety of neuronal classes generated in the cerebral cortex, distinct subtypes can act as pacemaker (Pm) neurons, able to trigger some of these events. Defects arising from alterations in the early cortical spontaneous activity have never been thus far systematically addressed, yet they can affect local assembly and physiological behavioural states.The IMPACT project aims to shed light on how cortical neuronal diversity influences early spontaneous activity, and to identify the molecular features and functional role of developing Pm neurons. By integrating innovative molecular strategies with in vivo optical recordings and behavioural assays, I will 1) characterise and spatially resolve the subtype-specific molecular footprints correlated with electrical profiles of neuron subtypes, with a special focus on Pm neurons; 2) assess molecular, cellular and circuit consequences of perturbations in Pm neuron activity; 3) identify novel functional modulators of Pm activity in the surrounding cerebrospinal fluid (CSF) around birth. IMPACT bears the ambition of filling the knowledge gap between the molecular and functional traits of developing cortical neurons, whi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Communication in Ancient Anatolia' (CAncAn) under Horizon Europe.

assistant: **Objectives**

The project addresses the question of messages, modes and participants in the communication of three Anatolian cultures, Lydians, Luwians and Phrygians, ca. 1200–546 BCE. Living in adjacent territories, they were verifiably in contact with one another. They are normally studied in isolation by different academic subjects, leading to missed intercultural references and interconnections, and preventing the reconstruction of a comprehensive picture. The three cultures, their interesting and diverse text sources, their relationships with one another and their (dis)unity as cultural entities are currently underresearched, and only parts of their text corpora are available in modern editions. The project will be the first to study both internal and external sources from other Ancient Near Eastern and Classical texts together, using a combined semiotic and narratological approach examining text structure, processes of meaning-making, communication and transmission. Texts and their material supports not only generate and exchange meaning, they also preserve information on communication processes in the context of specific realms. Reading these texts with a focus on narrative and discourse will allow a new insight into formative parameters of ancient societies, especially values, cognitive patterns, and the needs and motifs of the participants. This marks a huge shift from traditional, event-based readings towards an analysis of belief and behaviour. The project will be ground-breaking in its application and adaption of concepts from semiotics and narratology, which were developed for the study of the modern world and have never before been applied to the study of these ancient texts. The project will draw a new picture of cultural clusters and their parameters, and provide new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The political economy of euro-jordanian relations', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Embedded in the model of complex interdependence the political economy of Euro-Jordanian relations shall be analyzed by following a within-case- comparison thereby highlighting the limited explanation power of structuralist theories of International Relations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineered microbial factories for CO2 exploitation in an integrated waste treatment platform' (ENGICOIN).

assistant: **Innovation**

The ENGICOIN proposal aims at the development, from TRL3 to TRL5, of three new microbial factories (MFs), integrated in an organic waste anaerobic digestion (AD) platform, based on engineered strains exploiting CO2 sources and renewable solar radiation or H2 for the production of value-added chemicals, namely: MF.1) the cyanobacteria Synechocystis  to produce lactic acid from either biogas combustion flue gases (CO2 concentration ~ 15%) or pure and costless CO2 streams from biogas-to-biomethane purification.MF.2) the aerobic and toxic metal tolerant Ralstonia eutropha to produce PHA bioplastics from biogas combustion flue gases and complementary carbon sources derived from the AD digestate.MF.3) the anaerobic Acetobacterium woodii to produce acetone from the CO2 stream from biogas-to-biomethane purification.High process integration will be guaranteed by taking advantage of low-grade heat sources (e.g. from cogenerative biogas-fired engine or an tailored PEM electrolyser), exploitable side gas streams (e.g. O2 from electrolysis, CO2 from biomethane purification), low-price electricity produced during night-time by a biogas-fired-engine cogeneration unit or even intensified operation conditions (e.g. up to 10 bars pressure for the anaerobic acetone production bioreactor; led-integrated photo-bioreactor). This is an essential feature, alongside with the high conversion rates enabled by synthetic and systems biology on the above microorganisms, to achieve competitive selling prices for the key target products (1.45 €/kg for lactic acid; 3.5 €/kg for PHA; 1 €/kg for acetone).Notwithstading the key application platform (anaerobic biorefinery based on organic wastes) the innovative production processes developed have a great exploitation potential in other application contexts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photocatalytic C–H Bond CF3-diazomethylation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main goal of this Marie Skłodowska-Curie (MSC) application is to develop a new photocatalytic C–H bond CF3-diazomethylation of aromatic rings with a new class of hypervalent iodine reagents. Our approach is enabled by the photocatalytic generation of a previously elusive electrophilic carbyne radical, which is able to induce C-H bond cleavage. Preliminary results suggest that the proposed transformation will be able to functionalize complex drug molecules and provide valuable CF3-diazomethylated drugs. The useful reactivity of the diazo functional group (C=N2) contained on these molecules will be exploited to develop: (i) a small library of novel tetracycline antibiotics; and (ii) a [18F] labelling process; we aim to provide a robust and simple strategy for the simple synthesis of 18F-fluorinated probes to impact positron emission tomography (PET) imaging. A key strength of this multidisciplinary proposal is the introduction of a secondment phase, in an academic group, to evaluate the [18F] labelling, and a collaboration with a pharmaceutical industry to discover new antibiotics. The development of this project will enable the Experienced Researcher (ER) to become a leader for the next generation in the field of chemical synthesis and (radio)fluorination techniques by using the C-H functionalization logic. The ER will be exposed to a wide range of cutting-edge chemistry and biomedical sciences in two Top European Institutions (ICIQ, CICbiomagune) that will aid the development of his future research programmes as independent researcher. The high impact results expected will be published only in top journals and presented in major international conferences. Ultimately, this MSC application will contribute to enhance EU scientific excellence and allow the applicant to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Preventing Bone Loss by Targeting Endothelial Cell-Tissue Crosstalk' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

During healthy aging but also in osteoporosis, a disease that affects more than 22% of European women beyond the age of 50, loss of mineralized bone is caused by a disbalance between bone formation and resorption. While blood vessels are abundant in the skeletal system and play essential roles, they are currently not considered in the context of anti-osteoporosis therapy. Moreover, apart from the role of sex hormones, we know too little about the impact of sex-specific regulators in physiological and disturbed bone homeostasis.   Our recent work has provided fundamental insights into the organization of the bone vasculature in mouse, the heterogeneity and functional specialization of endothelial cells (ECs), and the changes during aging. Recent and unpublished research from my team has utilized single cell RNA sequencing in combination with advanced immunostaining and imaging to identify a novel EC subpopulation (termed type R for remodeling). Type R vessels are post-arterial capillaries found at sites of homeostatic and therapeutic bone turnover, mainly trabecular bone, and their activation in young mice can enhance osteogenesis. In aging mice type R vessel clusters emerge inside cortical bone at sites of bone loss. PROTECT will systemically characterize the function of ECs and, in particular, type R capillaries in healthy homeostasis and during bone loss. This will involve the generation of new mouse lines for intersectional genetics and the characterization of critical molecular regulators. We will also characterize sex-specific and age-related factors controlling bone homeostasis and employ approaches to translate our findings into the human system. Preclinical experiments in mice will establish whether ECs and type R capillaries are involved in the response to ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Stable ²¹¹At-labeled radiopharmaceuticals for targeted α therapy'.

assistant: **Concept**

Astatine (At) is the rarest naturally occurring element on Earth, exhibiting only short-lived radioisotopes. One of them, ²¹¹At, decays with a half-life of 7.2 h by emission of a highly energetic alpha particle, making it one of the rare alpha emitters suitable for targeted alpha therapy (TAT) of cancers, if bound to an appropriate cancer targeting molecule. Because the number of cyclotrons able to produce it has seen a significant rise in the past years, it is expected that ²¹¹At will become more accessible and play a major role in the development of TAT.Astatine belongs to the halogen elements, and despite more than 80 years since its discovery, many chemical properties remain to be discovered. This lack of knowledge is due to the absence of stable isotopes and the availability in minute amounts that preclude the use of standard analytical methods. Yet, research has shown that At behaves similarly to metals but also to halogens, forming bonds similar to its closest homologue, iodine, such as the carbon-At bond. This strategy is the main approach currently available to develop ²¹¹At-labeled radiopharmaceuticals. Yet, a lack of in vivo stability of the C-At bond is often observed, resulting in the release of ²¹¹At before it reaches its target and leading to irradiation of healthy tissues. Improving this stability is therefore a major challenge that remains to be overcome in order to unleash the potential of ²¹¹At in cancer treatments.In this context the objective of the SAt-Radio project is to explore alternative bonding modalities to the C-At bond in order to develop novel radiolabeling approaches with improved in vivo stability. The strategies developed will exploit both the halogen and the metallic character of At, using analytical and computational approaches that h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Chemistry in Protoplanetary Disks'.

assistant: **Objectives**

The study of the chemistry in protoplanetary disks is one of the current hot topics in astrophysics. The interest in studying these systems is that it permits to get insight into the chemical composition of protosolar-like nebulae at the moment when planets form. The faint emission of such systems and the small angular sizes they subtend in the sky have prevented for many years an extensive observational study, which is nowadays possible and is starting to be developed since the last ten years. This project aims at developing our current knowledge of the chemistry in protoplanetary disks from both a theoretical and an observational point of view. Specifically we propose to develop a computational code able to compute the evolution of the chemical composition in the various regions of disks treating in a detailed way the various chemical and physical processes which dominate the chemistry of these objects. We also propose to perform multiwavelength observations with current telescope facilities such as the IRAM 30-meter telescope and Plateau de Bure interferometer, the Very Large Telescope, and the Herschel Space Observatory, in order to detect new molecules and indentify good tracers of the various chemical and physical properties in the various regions of disks, such as the kinetic temperature, isotopic fractionation, the ionization degree, or the level of molecular depletion on grains. This research appears to be absolutely necessary now as it is expected that the large angular resolution of incoming telescopes facilities such as the Atacama Large Millimeter Array (ALMA) will revolutionize our current knowledge on the chemistry of protoplanetary disks. Such wealth of observational information will certainly need of a parallel development in the theoretical models in o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and Validation of an Automated Non-destructive Evaluation (NDE) Approach for Testing Welded Joints in Plastic Pipes' (NDE) under Seventh Framework.

assistant: **Objectives**

Plastics pipes offer significant advantages over other materials such as cast iron, steel, copper and concrete, for the transportation of fluids such as natural gas, water, effluent and corrosive liquids. They do not corrode; have a longer predicted service life, leading to less frequent replacement; they are less expensive to install due to their light weight and flexibility; and have significantly lower leakage rates due to having an all-welded system. However, their more widespread use is being restricted by the lack of a reliable non-destructive evaluation (NDE) method for the welded joints. Pipeline leakage does not only cause high repair costs but can also result in disastrous environmental consequences and even in loss of life. This project will develop phased array ultrasonic NDE procedures for butt fusion and electrofusion joints in PE pipes of diameters up to 1m and also for pipes in other plastics materials, including PVC, ABS, PP and PVDF. In addition, the project will also develop an automated inspection system that will be able to inspect pipe-to-pipe and pipe-to-fitting (elbows, bends, reducers, tees, etc) butt and socket joints in various plastic pipe materials and diameters between 90 and 1000mm. The development will be made by manufacturing welded joints containing known flaws. The NDE data will be analysed to determine the limits of flaw detection for each technique. In parallel, the significance of flaw size and quantity will be established in relation to service requirements. This will be achieved by long-term mechanical testing of joints containing known flaws, and comparison with results for welds containing no flaws. The prototype equipment, designed and built as part of this project will be assessed under both laboratory and field conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Expanding the chemical biology toolkit for the studies of histone post-translational modifications (PTMs)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Studying biomolecules in living cells is an important step towards understanding the cause and development of diseases. However, the existing tools dedicated to the study of biomolecules often lack generality and pose disturbance to the biological systems. Although bioorthogonal chemistry plays an important role in biomolecule studies, there are only a handful of bioorthogonal reactions that can modify these molecules in vivo.In this project, we will develop a novel biocompatible reaction that can be widely used for modifying biomolecules both in vitro and in vivo. We will then employ the reaction to reveal the biological significance of post-translational modifications (PTMs) of histones proteins by using two strategies. First, the histone mimics that are not accessible by the existing methods will be synthesized. These histone mimics can serve as important models for us to understand the interactions between histones and their regulating enzymes. Second, real-time imaging of histone PTMs in living cells will be made possible by using a chemical biology approach. This approach can minimize the disturbance to the three-dimensional structure of the nucleosome, thereby providing a true image of dynamic histone PTMs during cellular processes.In short, this multidisciplinary project lies on the interface of organic chemistry, biochemistry, and cell biology, with an aim to enable the in-depth studies of the unknown aspect of epigenetics.


**Keywords:** Chemical biology, Protein Chemistry, Post-translational modification, free radical reaction