RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Survival of the Fittest: On how to enhance recovery from critical illness through learning from evolutionary conserved catabolic pathways' (FitteR-CATABOLIC).

assistant: **Innovation**

Since a few decades, human patients who suffer from severe illnesses or multiple trauma, conditions that were previously lethal, are being treated in intensive care units (ICUs). Modern intensive care medicine bridges patients from life-threatening conditions to recovery with use of mechanical devices, vasoactive drugs and powerful anti-microbial agents. By postponing death, a new unnatural condition, intensive-care-dependent prolonged (>1 week) critical illness, has been created. About 25% of ICU patients today require prolonged intensive care, sometimes for weeks or months, and these patients are at high risk of death while consuming 75% of resources. Although the primary insult was adequately dealt with, many long-stay patients typically suffer from hypercatabolism, ICU-acquired brain dysfunction and polyneuropathy/myopathy leading to severe muscle weakness, further increasing the risk of late death. As hypercatabolism was considered the culprit, several anabolic interventions were tested, but these showed harm instead of benefit. We previously showed that fasting early during illness is superior to forceful feeding, pointing to certain benefits of catabolic responses.  In healthy humans, fasting activates catabolism to provide substrates essential to protect and maintain brain and muscle function. This proposal aims to investigate whether evolutionary conserved catabolic fasting pathways, specifically lipolysis and ketogenesis, can be exploited in the search for prevention of brain dysfunction and muscle weakness in long-stay ICU patients, with the goal to identify a new metabolic intervention to enhance their recovery. The project builds further on our experience with bi-directional translational research - using human material whenever possible and a validated mou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Elucidating the relationship between heterozygosity and fitness in a natural marine mammal population' (FURSEALFITNESS).

assistant: **Concept**

Many important fitness traits including longevity, reproductive success, parasite resistance, territory-holding ability, song complexity and even attractiveness often correlate with heterozygosity in natural populations.  Where documented, such heterozygosity-fitness correlations (HFCs) have the clear potential to influence interactions between pathogens and their hosts and the evolution of mate choice.  However, because most studies use only around ten neutral microsatellite markers, the proximate mechanisms underlying HFCs remain obscure.  Fortunately, next-generation sequencing approaches now make it possible to sequence DNA cheaply and on a massive scale, allowing large panels of Single Nucelotide Polymorphisms (SNPs) to be developed in virtually any organism.  By screening these in the Antarctic fur seal, a model system in which unusually high-quality measures of fitness are available, I will for the first time determine the mechanisms underlying a range of HFCs in a natural population and uncover actual genes linked to variation in key traits including longevity, reproductive success and attractiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DLM - forum 2002' to be submitted under Fifth Framework.

assistant: **Abstract**

The DLM Forum on electronic records promotes projects for the improvement in electronic records management and long-term preservation. It is a coordination point for policy, for the establishment of access and long-term storage standards and for the implication of private sector agents in searching solutions for electronic records problems. The third annual conference Access and preservation of electronic information: Best practices and solutions" will take place in Barcelona from 7-8 May 2002"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An apparatus for closed-loop hyperthermia therapy' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The main objective of the intended research project is to carry on a feasibility study of an innovative product for minimally invasive therapy (MIT) of cancer by hyperthermia. Hyperthermia is a therapy known and used for about 10 years in the treatment of cancer pathologies. It makes use of electromagnetic (usually RF) waves which produce heat in localised regions of the body. Several studies demonstrated that , in order to achieve the best therapeutic effects for the patient and, at the same time less pain for him/her, it is essential to know the real temperature distributions inside and outside the treated zone. The prime proposer of this project is currently manufacturing a system for hyperthermia featured by advanced solutions and well accepted in the national market. The main goal of the project is to develop an improved version of this apparatus machine based on a true technological innovation: in fact the new system will incorporate novel microsensors for measuring the temperature distribution in the body in a minimally invasive way. In particular the temperature microsensors will be able to: a) monitor the temperature distribution inside and around the tumour heated by the RF source, b) to allow closed-loop control of the RF source. These features are a real breakthrough in the field, and may allow the new apparatus to outperform all existing competing systems. In fact, present systems for hyperthermia are not widely accepted by the medical community due to the fact that they are unable to control accurately the temperature distribution in the body resulting from RF irradiation. Temperature measurements are carried on either inaccurately, as by means of non invasive techniques; or expensively, as by means of fiberoptic sensors; or painfully, as by means of tempe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Experimental access to volcanic eruptions: Driving Observational Potential' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Earth System is impacted continually by dozens of volcanic eruptions per year. Predicting their collective effects is hampered by our incomplete mechanistic understanding of eruptive and post-eruptive processes. The activity of explosive volcanic systems especially, is a key to the evolution of our world, not only for the eruptive catastrophes themselves but also for the massive injection of volcanic materials into the critical zone of the Earth System. (e.g. Ayris and Delmelle, 2012; Baldini et al., 2015; Dingwell, 1996; Dingwell et al., 2012; Martin et al., 2009; Robock, 2000). For this reason - as well as the many pragmatic issues of living with active volcanism – a mechanistic understanding explosive volcanism and the interaction of its products in the Earth System is a grand challenge of modern Earth Sciences.Fortunately, three recent experimental breakthroughs bring the challenge of mechanistic understanding within our grasp: these are the development of in situ high temperature 1) synchrotron-based real-time imaging techniques for deforming systems (Baker et al., 2012; Wadsworth et al., 2016). 2) acoustic monitoring of failure and fragmentation processes in exploding magma (Arciniega et al., 2015) and 3) dynamic ash-gas environmental reaction chambers (Ayris et al., 2015).Accompanying these experimental advances, have been fundamental advances in our mechanistic view of magma ascent and eruption (Tuffen et al., 2003; Gonnermann and Manga, 2003; Lavallée et al., 2008; Castro and Dingwell, 2009), volcano seismicity (Arciniega et al., 2015; Vasseur et al., 2017) , and the fate of volcanic ash (Delmelle et al., 2018; Renggli et al., 2018). Vast experimental expertise, together with the global impact of our work to date, place me uniquely to exploit these recent a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OBSERVATORY OF THE DYNAMICS OF INTERACTIONS BETWEEN SOCIETIES AND ENVIRONMENT IN THE AMAZON' to be submitted under Horizon 2020.

assistant: **Abstract**

Achieving a sustainable development trajectory in Amazonia is one of the key challenges facing Brazil, and is also an important international concern. ODYSSEA assembles an internationally renowned European and Brazilian multidisciplinary and intersectoral team. We aim to produce fundamental science and tools in order to build an innovative multi-and interdisciplinary observatory to monitor and assess dynamic interactions between Amazon societies and their environments. This observatory will serve as a basis for policy development that integrates social, environmental, political-economic and human health dimensions. Our methodology puts the society at the heart of the observatory’s building process, engaging stakeholders and decision makers in the research to favour advancement of their objectives and commitment to sustainable development issues.Building on knowledge framed around ongoing bilateral projects, ODYSSEA brings together several independent networks of international and Brazilian researchers which all have long-term experiences in the Amazon of environmental and social research, each with their own expert skill-sets. We expect significant advances in our understanding of the different feedbacks and linkages between the panoply of pressures exerted on the environment, the factors determining the vulnerability of local populations to environmental shocks and in the evaluation of governance and institutional arrangements aiming at promoting adaptation. We aim to enhance the capacity of Brazilian institutions to assess and reduce the vulnerability of populations in Amazonia.ODYSSEA will help unify an increasing number of bilateral arrangements for research and innovation between individual European countries and Brazil. Whilst these connections are proving fruitfu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Space Qualification and Validation of High Performance European Rad-Hard FPGA' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The OPERA project sets clear and measurable main objectives to reach a TRL 7 as follows: 1. Validation and tradeoff by end users of NanoXplore rad-hard FPGA (NG-LARGE and NG-ULTRA) – TRL 6 achieved. 2. Development and testing of very complex ceramic hermetic package CGA 1752 – TRL 6 achieved  3. Space ESCC technology Flow Qualification  of NanoXplore's rad-hard FPGA (NG-LARGE) – TRL 7 achieved  The proposed activity is part of a jointly agreed space FPGA roadmap between EU, the European Space Agency, the CNES and the key European space equipment manufacturers. It is supporting the Strategic Research Agenda of the European Space Technology Platform. The proposed activities will address applications beyond the space market such as avionic, energy and transport. OPERA is set up to validate and do the ESCC technology Flow Qualification  of advanced rad-hard NG-LARGE FPGA with minimum risk execution and best product time to market. The project will give access to state of the art qualified rad-hard FPGA NG-LARGE and prepare future applications for the most advanced FPGA in the world NG-ULTRA. The project will enable the two European largest satellite vendors Thales Alenia Space and Airbus DS to evaluate both NG-LARGE and NG-ULTRA to better assess which FPGA is more suitable for a defined application. NX is developping a familly of FPGA to adress the whole space market and it is key to validate the limit and the possibilities for each FPGA. TAS and ADS will also start developping state of the art applications to speed up products dissemination.   OPERA is fully in line with ESA / EU activities and will merge outcomes from different projects to reach a TRL 7:ESCC technology Flow Qualification  rad-hard FPGA developped in the BRAVE project Take benefit of the programming softwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Jet quenching for heavy-ion collisions at the LHC' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The characterization of the quark gluon plasma (QGP) created in heavy-ion collisions (HICs) is the main goal of heavy-ion experimental programs at the Relativistic Heavy Ion Collider (RHIC) at BNL (USA) and at the Large Hadron Collider (LHC) at CERN. Jet quenching, the modification of jets in a colored medium, is one of the most successful tools to probe the QGP. This proposal aims to provide an interpretational framework for jet quenching that maximizes the discovery potential of the current (and future) precision era of HICs.Since the study of jets in the presence of a medium is challenging, we still lack a first-principles formalism for jets in HICs. In contrast, a wide variety of jet quenching Monte Carlos (MCs) are available, but they rely on phenomenological assumptions making difficult to interpret their outcomes. It is proposed here to develop the first jet quenching bottom-up formalism based on first principles. This will be done by generalizing from single hadrons to jets a previous implementation by the experienced researcher (ER), including different phenomena as coherence. This analytical approach will become a unique tool to describe the QGP and benchmark the mainstream MCs.The theory of jet quenching has been developed assuming a QGP in thermal equilibrium. Recently, the ER has shown for the first time that jets in HICs are sensitive to the pre-equilibrium dynamics of the evolution. This finding paves the way for a completely novel line of research in HICs, whose ambitious goal is to access these poorly understood initial stages with jet quenching observables. This proposal will provide the foundations for such an effort by phenomenologically analyzing the possible explanations to this finding and by computing color field configurations for the initial st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Institutions and REsearch in the Pantanal: towards a bioregional research agenda to support Policy Institutions, Legal Frameworks and Social Action' (INREP).

assistant: **Concept**

The main objective is, in order to develop sustainable water management at river-basin scale and efficiency in water use in the Pantanal, to strengthen the cooperation between policy makers, stakeholders and scientific institutions in Brazil, Bolivia and Paraguay and to stimulate the cooperation between these three countries, the European science community and NGO's working in the region. European environmental research groups from different countries have long-term research ongoing in the area in diffe rent but related fields, but they do not yet cooperate nor is there an established linkage with authorities. NGOs work in the region, but do not yet cooperate closely with European research. The project proposes to build an agenda for an international r esearch area in which Brazil, Bolivia and Paraguay, the European Union and others can cooperate. The objective consists of two parts: -Developing insight in the scientific, political and social-economic actions, problems and solutions in the   sustainable management of the Pantanal and the Upper Paraguay River Basin (UPRB); -Strengthening institutional and scientific cooperation at national and international levels for the region. To obtain these general objectives, the following working objectives have been formulated: -Realisation of preparatory workshops and a biregional symposium (Latin-America-Europe); -Development of a Research Agenda for the Pantanal; -Report to the Brazilian, Bolivian and Paraguayan governments and the European Commission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing the supply chains for industrial hemp fibre and bio-based resins towards high performance circular bio-based composites' (SSUCHY-Next).

assistant: **Innovation**

SSUCHY-Next builds further where previous BBI SSUCHY stopped in 2022. Ambition is to bring different parts of the hemp fibre supply chain to TRL 7, through production at scale of various fibre products, covering the complete value chain from field to composite. Two value chains are further developed. Fibres are extracted by either scutching or by breaking roller/card, linking into different geographical regions. Hackled and carded slivers are further processed into high quality preforms for composites: woven and quasi-UD fabrics and purely UD hemp tape. The appearance at industrial scale of high quality hemp fibres would give a boost to plant fibre composites in competition with glass fibre composites, offering both an environmentally sound and cost effective alternative, especially with less expensive medium length fibres. With hemp fibres which are largely circular, one of the major bottlenecks for a further breakthrough of bio-based composites has been the lack of (fully) bio-based, environmentally sound and as well cost efficient polymer matrices. Hence, our ambition in SSUCHY-Next to work on 3 bio-based resins: bio-based acrylic polymer (“Elium®”) with very high bio-content,  and fully bio-based benzoxazine and BG-epoxy, building upon developments in SSUCHY. All systems developed to TRL 6 or 7. To demonstrate the viability of the materials, various inspiring applications are developed to TRL7. We demonstrate the design, production, testing and certification of a 12.6 meter long wind turbine blade, made from hemp and bio-based acrylic. Wood-based products are developed, based on infiltrated wood scaffolds, in first instance with fluid acrylic; also a hybrid wood-based product with hemp reinforcement is included to produce a high performance construction material. La
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigation of the interaction of mesenchymal stem cells with aptamer modified surfaces using Light-Addressable Potentiometric Sensors (LAPS)'.

assistant: **Concept**

The aim of this project is to develop a new method to immobilize aptamers of stem cells onto silicon-on-sapphire substrates, to capture cells by affinity interaction between aptamer and target cells, and investigate two-dimensional electrochemical images of parameters such as local cell impedance, cell surface charge, ion channel activity, and two-photon fluorescence images with subcellular resolution using the impedance imaging technique Scanning Photo-induced Impedance Microscopy and the electrical potential imaging technique Light-Addressable Potentiometric Sensors. Aptamers are artificial functional oligonucleic acids which can bind their targets with high affinity and specificity. Aptamers with specificity to target integrin heterodimers will be developed and patterned on LAPS substrates and the mechanism of attachment regulated stem cell differentiation studied. The proposed technique has the advantage that functional electrochemical imaging of the cell-surface interface can be carried out, which is not accessible to other electrochemical techniques.The results of the project will inform the development of tissue engineering materials and impact on the health care and biomaterials industries, which are central to Europe's ongoing and future economic success, and are directly relevant to the theme priority of personalizing health and care in Horizon 2020.The applicant is an outstanding young scientist who recently finished his PhD at Peking University and has already authored and co-authored 14 papers, worked on different multidisciplinary projects in China and Japan, and brings a lot of relevant experience to the project in the areas of aptamers, electrochemistry, and biosensors. During the fellowship, he would develop competencies in electrochemical imaging, semi