RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ROLE OF RIBOSWITCHES IN REGULATING METABOLISM IN ALGAE' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Thiamine pyrophosphate (TPP) is the active form of vitamin B1. As well as being an important cofactor for primary metabolism, TPP also controls gene regulation through riboswitches in bacteria, fungi, plants and algae. Riboswitches are evolutionarily conserved sequences in the mRNA to which a metabolite binds directly, thereby affecting expression of the protein. In the green alga Chlamydomonas reinhardtii, riboswitches have been found to control gene expression of two thiamine genes, THIC and THI4. To date, studies on riboswitches remain descriptive. Here we propose to investigate, for the first time, in vivo, the role of riboswitches in regulating biosynthetic pathways, using the thiamine pathway in C. reinhardtii. This will be achieved by analyzing the vitamin B1 metabolism of THIC mutants transformed with a functional THIC gene with or without its riboswitch. Additionally, TPP riboswitches will be introduced into yeast, which lacks riboswitches. Data will be used to build a mathematical model of thiamine metabolism with or without riboswitches. We also plan to look for new ‘TPP riboswitch-controlled genes’ by differential display proteomics. This will also give us the opportunity to create a promising molecular tool for the fine-tuning of gene expression. As a proof of concept, a TPP riboswitch will be fused to a reporter gene and transformed either into the nucleus or into the chloroplast of C. reinhardtii. This will allow us to manipulate gene expression and investigate gene function by adding vitamin B1 to the medium. The research project will bring new insight to our understanding of regulation of vitamin metabolism. This will facilitate our ability to manipulate vitamin levels in plants thereby improving their nutritional quality. Understanding vitamin and cofa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mobile pelletizing unit' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The biopellet market is booming in Europe, and the production of wood pellets (main commercial product) has increased from 6-7 to 26 Mton/year in the period 2006-2015, and is expected to rise to 38 Mton/year in 2025, due to the general interest in substituting fossil fuel with CO2 neutral biomass. There is a need of solutions to utilise the potential of biomass residues currently available in forests, agriculture, agroindustry and parks, not being used today as it is too expensive to handle and process the feedstock. Our innovative solution consists in a mobile pelletizing unit, placed on a trailer that can be connected to a normal truck for transportation. This eliminates associated costs with buying land and obtaining building and permissions. The raw material is crushed, milled, dried, and pressed to biopellets. Our solution can handle a large variety of raw material, like straw, nut shell, rice husk, etc., although the main raw material is expected to be wooden residues. Only one operator is required, and the unit can produce up to 1.2 ton/h with a low energy consumption. Our first sales is expected to be in Switzerland and in France. By 2026, it is expected to have sold more than 400 units.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'From molecular biology to clinical management: a novel approach for the long qt syndrome'.

assistant: **Innovation**

The major goals of our project are:1) to extend the clinical knowledge of LQTS by establishing for the first time the clinical features of each form of LQTS based on genetic characterization of the different families;2) to identify, or clarify, the genetic abnormalities in LQTS and assess their electrophysiologic equivalents both in expression systems and in tissue samples from affected individuals;3) to develop in vitro models reproducing the specific electrophysiologic defect of the different forms of LQTS in order to have an experimental setting in which new therapeutic approaches could be tested and4) to identify and test targeted and individualized therapies for the various affected families according to the specific ionic abnormality present in their members.The long QT syndrome is an inherited disorder that causes abnormal prolongation of ventricular repolarization (clinically measured as a prolongation of the QT interval on the electrocardiogram) and is associated with the frequent occurrence of life-threatening ventricular tachyarrhythmias that eventually lead to the sudden death of most affected and not properly treated patients. Linkage analysis has allowed the identification of four chromosomes linked to the disease (chromosomes number 3,4,7,11). Since LQTS is a relatively rare condition, a transnational collaboration is necessary for the concentration of a multidisciplinary research project. The present project has a multinational organization and is multidisciplinary, as each country involved will have both clinical and molecular biological expertise in order to provide a comprehensive functional unit. Yet all data will be entirely shared in order to avoid time consuming errors in pursuing wrong directions of investigations.Three major levels of research a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of new vaccine candidates against group A Streptococcus by proteomics analysis' (GASVACCINE) under Sixth Framework.

assistant: **Objectives**

The post-genomic era offers exciting new opportunities for vaccine research, which are expected to shorten the time of vaccine. The complete knowledge of the gene repertoire of a given pathogen can become the launching platform for three approaches aiming at the identification of new vaccine candidates. According to one strategy, named reverse vaccinology, genes are selected in silicon utilizing algorithms that can predict genes encoding for secreted and surface-associated proteins and virulence factors. These proteins are considered the most relevant for the induction of a protective immune response. The second approach is aimed at the identification of invasion and virulence-associated antigens and make use of several new technologies including in vivo expression technology, signature-tagged autogenesis and DNA micro array technology. In the third approach, surface exposed antigens are selected experimentally through the characterization of membrane proteins fraction usingproteomics techniques such as two dimensional gel electrophoresis, or two dimensional chromatography and mass spectrometry. The specific area of research in which the proposal refers is to identify a set of potential vaccine candidates against Streptococcus progenies (group A streptococcus, GAS) using a proteomics approach. This approach will complement a reverse vaccinology approach, and a DNA micro array technology based approach already initiated in the laboratory. A range of illness and disease has been associated with GAS infection including pharyngitis, impetigo and scarlet fever. More invasive infection can because by GAS including toxic shock syndrome and narcotising fascistic, as well as rheumatic fever and rheumatic heart disease. GAS infections have increased in frequency and severity in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Earthquake Risk plAtform For european cities Cultural Heritage protection'.

assistant: **Concept**

The seismic movements of the ground have a strong impact on the structural stability of the Cultural Heritage very often characterized by old construction methods and materials but still with a consistent density of population. To have an idea of the dimension of the phenomena, the damage on the CH asset declared by the Italian Ministry of CH, caused by the recent earthquakes in Centre Italy, has been assessed in 2 Billion Euro plus the death toll caused by the collapse of several buildings. Authorities responsible for the preservation of CH to the future generations are well aware of the huge costs required by rehabilitation intervention compared to preventive ones. Risk information becomes fundamental to reduce the vulnerability of heritage and to minimise the economic losses, helping disaster managers and cultural heritage professionals to design mitigation measures, set priorities and invest in resilient cultural heritage to mitigate the restoration costs and the death toll.The project ERA4CH addresses the development of a series of tool, combining Artificial Intelligence with structural stability models, advanced remote sensing techniques, image processing, geotechnics and cadastral data sets in a GIS application for damage assessment and long-term monitoring of historic centres. This innovative methodology and tools will enable effective monitoring and management of the historic centres to mitigate the effects of the catastrophic events by enabling preventive intervention in the areas where the majority of the damage is expected.  Three representative test cases are proposed: the historic city of Narni (Italy), candidate to the UNESCO site list, the historical centre of Chania (Crete, Greece) and Strovolos (Nicosia, Cyprus).


**Keywords:** Earthquake risk assessm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolutionary dynamics of growth factor production in cancer cell populations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cancer is a process of clonal selection, and analytical methods from evolutionary biology should be able to explain why cancer tissues are heterogeneous and develop resistance to current therapies. Evolutionary game theory helps understand non-intuitive properties of the frequency-dependent dynamics arising in the cooperative interactions between cancer cells. In particular, the theory of N-person non-linear public goods games is used to analyse the evolutionary dynamics of the production of diffusible molecules like growth factors, which are essential in the development of cancer. Models that take into account general features of non-linear public goods in structured populations, as well as specific features of certain types of growth factors, are used to understand the ultimate causes of tissue heterogeneity and of the evolution of resistance to therapies. The second part of the project uses experiments with cancer cell populations in vitro to test the predictions of the theory. Two types of beta cells from insulinomas of mouse, one of which knocked out for insulin-like growth factor-II (IGF-II), a factor that promotes cancer cell proliferation and survival, are used for experimental evolution in vitro. It is anticipated that IGF-II-deficient tumour cells, while unable to grow in the absence of IGF-II, will proliferate better than producer cells when IGF-II is provided exogenously or by co-cultured producer cells, making IGF-II a public good, and providing an example of cooperation among cancer cells. The results will help understand stable intra-tumoural cell heterogeneity, why therapies that target growth factors lead to a temporary reduction in tumour growth followed by relapse, and may help devise evolutionarily stable therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Biopolymer Based FOOd Delivery Systems'.

assistant: **Innovation**

The “BIopolymer BAsed FOOd Delivery Systems” (BIBAFOODS) network will train young researchers for the advancement of food science and technology, by providing them with the complementary skills necessary to develop the future sustainable food industry and entrepreneurial skills crucial for creating biotechnological food oriented start-up companies. This collaborative training network will combine the complementary training capabilities of each individual partner institution to improve the trainees’ chances for employment and promote health and welfare in the EC by providing the capability to develop novel functional foods. The scientific focus of the research training is on colloidal delivery systems to protect and deliver active components via foods, resulting in novel functional foods. The development of these systems is to be based on only food-grade ingredients and upon economical feasible processes. The hypothesis is that the materials and coatings can be made responsive to the external chemical conditions and therefore suitable for controlled releases targeted at a desired stage during food processing or at a specific point during digestion of the food, e.g. in the intestinal tract. This will involve probiotic bacteria and enzymes that are liberated and allowed to be active in a controllable way. The ultimate successful materials ensure stability of the active component during long term storage prior to food production, during food production or during digestion, but at the same time liberating the active component at the right point. The behaviour and interaction of the delivery systems will be studied by simulation of gastric and intestinal conditions and by implementation in food production and formulation into probiotic products. To summarize, through the trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Capabilities of advanced traffic management tools' in the context of a Fourth Framework call.

assistant: **Objectives**

Prima will assess the acceptance of road pricing schemes, it will evaluate different scheme designs in terms of both technical feasibility and acceptability and, third, PRIMA will develop guidelines for removing barriers to implementation. Public choice theory, utility theory and the theory of networks are examples of different theoretical concepts that try to explain the phenonemon of public acceptance. In applying them to new practical evidence gained in the below mentioned schemes PRIMA will undertake to better understand and predict public acceptance of road pricing schemes, which in turn is the main prerequisite for their successful and more widespread use. The findings will be discussed at assessment workshops and a conference, and will be presented in the form of a strategic implementation guideline. The purpose of the guideline is  - to provide practical advice on how to guide the process of implementation - to show in a process-oriented way how to gain acceptance  - to take account of requirements for interoperable urban-interurban interfaces - consider legal and organisational barriers at different institutional levels (city, region, national, EU). %Zurich, Lyon, Marseille, Stockholm, Oslo, Bern, Barcelona, Rotterdam/Randstad %PRIMA follows up on the EU Commission's 'Green Paper on Fair and Efficient Pricing in Transport' and the ' White Paper on Fair Charging for infrastructure Use'. It builds on predecessor projects carried out under the Transport RTC Programme such as EUROTOLL, PETS, QUITS, TRENEN II/STRAN. Its results will feed into the CAPRI concerted action, and in this way links will be estabilished with the PATS project which runs in parallel. Projects of the TAP Programme related to road pricing will be taken into account, e.g. VASCO, ADEPT II, MOVE-I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of novel management strategies for invasive aspergillosis' in the context of a Sixth Framework call.

assistant: **Objectives**

Our proposal is to develop new treatment strategies for Invasive Aspergillosis (IA) which has become the major infectious complication of treating haematological malignancies with intensive chemotherapy or haematopoietic stem cell transplantation (HSCT). It meets the criteria of the call by addressing a disease with a significant economic cost due to resistance" to treatment with available agents and high associated mortality. Ineffective host immune responses facilitate fungal invasion of the pulmonary system and other vital organs leading to death.In order to redress this immunological imbalance we propose to develop new immunotherapeutic strategies which will augment current antifungal treatments and reduce morbidity and mortality. We plan to study high risk patients undergoing allogenetic HSCT to prove our hypothesis that immunotherapy is efficacious. Facilitated by recent publication of the Aspergillus fumigatus (the principal pathogen of the genus) genome sequence we will exploit new knowledge and techniques in genomics and proteomics. We will identify the immuno-logically important fungal targets to aid design of immunotherapies based on vaccines using fungus-primed innate immune cells, monoclonal antibodies or adoptive transfer of specific T lymphocyte clones. We will also generate new nucleic acid based diagnostic tests to inform when and how immunotherapy can be optimally applied.The findings generated will be of great relevance to treatment of haematological malignancies throughout the EU by significantly reducing HSCT related mortality, by allowing more intensive cancer treatment regimens to be used leading to higher remission rates, and will also be applicable to other patient populations at risk of IA. The outcomes will have strong commercial applications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Importance of Barriers to Bird Migration' (BIRDBARRIER).

assistant: **Concept**

Understanding animal migration is one of the most compelling and challenging problems of modern biology. For a long time, we have been hindered by the large geographical scale of migratory movements and the small sizes of most migratory animals. Crossing barriers is a fundamental aspect of animal migration. Long-distance migratory birds face crossings of formidable barriers such as the Sahara Desert, Himalaya Mountains, or the Pacific Ocean twice a year, but even short-distance migrants travel across inhospitable habitats. Successful migration, and specifically successful barrier crossings, depend on the availability of favourable weather conditions aloft and suitable habitat during stopovers. Surprisingly little is known about the behaviours that guide billions of avian migrants to a successful barrier crossing. Advances in tracking technology and remote sensing now offer us new tools to track small migratory animals with extraordinary precision. I will use these new methods to study how nocturnally migrating songbirds manage barriers during their migration. With this action I aim to increase the understanding of (1) the behavioural strategies that birds use to negotiate large geographic features and (2) how barriers limit bird migration. The research will be conducted under PI Prof. Kasper Thorup in the Bird Migration Lab, Center for Macroecology, Evolution and Climate, at the University of Copenhagen. Prof. Thorup’s group has advanced the front of global scale tracking of avian migration for the last decade, and possess the necessary expertise in spatiotemporal patterns. Further, I will spend a secondment at the Institute of Avian Research, Germany, and gain from Dr. Heiko Schmaljohann expertise in stopover behaviour. By combining my existing expertise in radioteleme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Centre for low temperature studies of promising materials for applications'.

assistant: **Innovation**

CELTAM - strong and innovative Centre of research and education, will lead the Institute for Low Temperatures and Structure Research (ILT&SR) to full integration with the European Research Area by intensifying its collaboration with foreign scientific centres. It will conduct the research on novel materials for applications in electronics, optics and laser technology, founded on experience and low-temperature methods developed in ILT&SR. Objectives will be achieved through workshops and conferences, networking with other centres, twinning with a selected partner, developing international education activities and increasing the access to information. We expect to develop new fields of material research, give large number of students a multidisciplinary and international perspective on their work, and improve human potential of CELTAM.