RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A highly efficient and eco-friendly electric shower offering health benefits through magnesium sulphate' under Horizon 2020.

assistant: **Concept**

According to reports by the US ‘National Institutes of Health’ (NIH), most western populations are magnesium deficient. Magnesium deficiency can lead to a number of health problems such as high blood pressure, heart disease, stroke, osteoporosis and arthritis, to name only a few. Sulphate is also essential for many biological processes and at the same time sulfation is a major pathway in detoxifying drugs and environmental contaminants. According to the School of Biosciences of the University of Birmingham, sulphate is not easily absorbed across the gut wall. The recommended treatment up to now for absorbing these nutrients was bathing in Epsom salts, a procedure that calls for a considerable amount of time, water and electrical energy.  MgSO4 Ltd (UK) has developed and patented MgSpa, a new revolutionary alternative to electrical showers, which enables the user to quickly and effectively absorb the necessary Magnesium and Sulphate through the skin, while at the same time ensuring huge savings in water (97% less) and energy (80% less). The MgSpa makes the Epsom salt treatment an easy low cost everyday habit, like taking a shower.The concept behind the product is to make use not only of the therapeutic properties of the salts, but also of their cleaning ability. So far, the use of soaps made water recirculation in showers impossible and the showers’ water and energy consumption significant. The innovative product uses Magnesium as a cleaning agent and recirculates and reheats shower water to create an invigorating shower experience with minimum environmental impact.The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and planning all activities for deploying a large scale pilot supported by a l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening Portuguese research and innovation capacities in the field of excess reactive nitrogen' (NitroPortugal).

assistant: **Concept**

Nitrogen (N) is a key nutrient, indispensible for the survival of all living organisms on earth, including Man. However, due to human pressure, the N cycle has become the most altered among the element cycles, highlighting the N problem as one of the most pressing environmental issues faced today. Despite the recent work on nitrogen in Europe and the rest of the world, Portugal has not so far utilized its full capacity to integrate the available scientific, technical or practical knowledge. NitroPortugal addresses how to improve the S&T skills and the scientific output of Portugal, at the same time strengthening the potential for N policy application. The project develops around the consensus that N is an emerging issue, that it impacts all the environmental compartments, and has both human health and social implications. This twinning effort on N is divided into five key areas which coincide with the whole N concept WAGES (Water, Air, Greenhouse gases, Ecosystems and biodiversity and Soil) launched by the European Nitrogen Assessment. Based on bringing together existing data on data analysis and on training in new methods for each of the five key topics, a comprehensive analysis will be delivered that prioritizes the key gaps in knowledge. These gaps will then serve as themes for different types of training activities. Emerging questions will feed brainstorming workshops to be held at key points through the project, which will strengthen the Portuguese skills base and enhance peer-review publication. Based on the new skills of the host country team, the basis for preparing a Portuguese Nitrogen Assessment will be obtained that will strengthen Portuguese engagement within the EU and in UNECE Air and Water Conventions. The resulting increase in scientific productivity, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Telomeric Repeat Containing RNA: Biogenesis, Composition and Function'.

assistant: **Concept**

The ends of eukaryotic chromosomes, known as telomeres, play crucial roles as guardians of genome stability and tumor suppressors. Telomeric DNA is maintained by the ribonucleoprotein enzyme telomerase. Most normal human somatic cells express only very low levels of telomerase and telomeres shorten with continuous cell division cycles. Ultimately, short telomeres activate a DNA damage response that leads to a permanent cell cycle arrest or apoptosis. Reactivation of telomerase is a key requisite for human cancer cells to attain unlimited proliferation potential.    The key questions that need to be tackled in the telomere field are (1) how telomeres protect from DNA repair activities, (2) how recruitment and regulation of telomerase is mediated by telomere structure, (3) how cell cycle arrest occurs upon telomere shortening, and (4) how telomeres regulate their heterochromatic state. In all four areas, important progress is expected in the near future.   We recently made the unexpected discovery that telomeres are transcribed into TElomeric Repeat containing RNA (TERRA) and that this RNA is an integral part of telomeric heterochromatin. Our working hypothesis is that the telomere is an RNA-dependent machine, and that several if not most of its crucial functions are regulated by TERRA. In this proposal we will explore TERRA functions, by elucidating its biogenesis, by identifying its protein partners and by genetic manipulation of the expression of TERRA and TERRA binding proteins. This work should provide fundamental insight into how our chromosome ends function. The gained knowledge may also provide novel avenues on how to manipulate telomere function and dysfunction in cancer cells and other diseased tissue.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design and Versatile implementation of nonbinary wireless communications based on innovative LDPC codes' (DaVinci) targeting Seventh Framework.

assistant: **Abstract**

The DaVinci project aims at developing new technologies targeting future B3G or 4G wireless broadband transmission systems such as IEEE 802.16e/m, or 3GPP-LTE. It is well known that the increase in data rate and heterogeneous transport in wireless networks demands very efficient coding schemes, coupled with adaptive resource allocation strategies. Beside the recent progress made these last 15 years, coded modulation schemes presenting near-Shannon performance at high spectral efficiency with short blocks are still missing. Besides, whilst most of the European technology has focused on Turbo-Codes (3GPP, DVB-RCS, IEEE 802.16), it has facilitated as a side effect development of the competing technology, namely LDPC codes worldwide (3GPP2, DVB-S2, IEEE 802.11n).<br/>In order to ensure European supremacy in enabling technologies mandatory for IMT-Advanced systems, the DaVinci project plans to go beyond usual LDPC codes, and develop breakthrough channel coding, together with tailored Link Level technologies. The DaVinci solution is based on systems which completely operate using high order nonbinary symbols, in all receiver blocks. However, the expected performance gain comes at the expense of increased hardware complexity, and unsolved technical issues such as nonbinary Hybrid-ARQ strategies, or nonbinary turbo-receivers. Consequently, low complexity nonbinary LDPC codes/decoders will be developed in the DaVinci project, and compared in a realistic framework, using a versatile FPGA implementation and real link using a MIMO-OFDM platform.<br/>Our consortium has a strong expertise in the design of efficient, but practical B3G/4G communication systems, and we believe that the joint design of the code, the resource allocation and the hardware model is the necessary basis for pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hydrogen Offshore Production for Europe' under Horizon Europe.

assistant: **Concept**

Hydrogen Offshore Production for Europe (HOPE) intents to pave the way for the deployment of large-scale offshore hydrogen production. To this aim, HOPE will design, build and operate the first offshore hydrogen production demonstrator of 10MW by 2025 in an offshore test zone near the port of Oostende in Belgium. The two-years demonstration of a mid-scale concept on a retrofitted jack-up barge will prove the technical and commercial sustainability of renewable offshore hydrogen production, export by pipelines and supply to end-clients onshore. It will also provide an extensive experience to assess the feasibility of 300MW and 500MW offshore concepts. The experience gathered by the consortium members and the maturity levels reached at the end of the project will enable the deployment of commercial large-scale solutions as soon as 2028.HOPE gathers a unique consortium of European players with cutting-edge expertise across the whole hydrogen value chain: an offshore wind power developer, a renewable hydrogen producer, an electrolyser manufacturer, a desalination solutions manufacturer, an offshore hydrogen pipes manufacturer, a research centre, a regional development agency, a strategic consultancy and a renewables communication agency.HOPE will produce a large range of exploitable results including not only detailed designs of replicable offshore hydrogen technologies, operational data and resulting analyses from a first-of-a-kind project but also pre-feasibility studies and techno-economic assessments of two large-scale concepts. Through an ambitious dissemination and exploitation plan, the consortium intends to accelerate the deployment of large-scale offshore hydrogen solutions to contribute to reach the 10 Mt of clean hydrogen produced in Europe by 2030 to decarbonize
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PILOTs for robotic INspection and maintenance Grounded on advanced intelligent platforms and prototype applications'.

assistant: **Innovation**

Current European refineries and civil infrastructures, like tunnels and bridges, are ageing, and therefore gradually become deteriorated, especially taking into consideration the current and future economic situation in Europe where large investments in renewing infrastructures are not foreseen. Then, it is paramount important to increase the efficiency and quality of inspection and maintenance activities in order to keep the necessary safety levels in these ageing infrastructures. To overcome this important challenge, PILOTING proposes the adaptation, integration, and demonstration of robotic solutions, in an integrated platform, which will be tested and evaluated in three large-scale pilots: refineries (Oil&Gas sector), bridges/viaducts and tunnels (Civil/Transport Infrastructure sector) with the involvement of all the actors that conform the full value chain. The developed platform will: demonstrate the application of robotics at scale in the domain of Inspection and Maintenance (I&M), reduce end-user commercial risks on the deployment of robotics in the sector, demonstrate capabilities and improve understanding of robotics uptake value, develop and support the related ecosystem around the piloting I&M operations, as well as, contribute to industrial standards in robotics for I&M. To achieve the above, PILOTING will develop an advanced robotic-based platform that will be deployed in the three industrial scenarios and demonstrate the real value towards the inspection and maintenance community as well as its high level socio-economic impact when applied at scale. PILOTING will establish large-scale pilots in real industrial environments to directly reply to main I&M challenges through the demonstration of: increasing rate of inspection and maintenance tasks, improving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced Design of High Entropy Alloys Based Materials for Space Propulsion' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The development of next generation space exploration propulsion systems requires high temperature materials able to guarantee low density, high strength and ductility, oxidation resistance, good creep properties.High Entropy Alloys (HEA) are an excellent candidate due to their potential high specific strength and oxidation resistance at high temperatures and have been identified as possible replacement for superalloys in propulsion systems components.HEAs are relatively new class of materials and although since 2004 more than 600 HEA journal and conference papers have been published the whole HEA world still leaves un-answered questions. Therefore, in order to exploit these advancements on HEA, further work is needed.The main goal of ATLAS is to take over the present limitations and unsolved issues that limit the utilization of HEA through multidisciplinary materials design framework that advances the state-of-the-art of High Entropy Alloys and related materials compounds towards the practical needs (current and future) of the space propulsion industry. To achieve this ambitious result the following challenges will be addressed: defnition of an accurate  material property database, design of the HEA, definition of Hybrid/Compound solutions with combination of HEA materials joined to Ceramics and/or Ceramic Matric Composites (CMCs) to create lightweight and temperature resistant functional materials, manufacturing of near-net shape manufacturing and materials integration/joining with Ceramics and CMCs.To produce the HEA materials and related compounds materials designed within the project two different additive manufacturing processes will be used from the production of coupons and samples to the final full scale demenstration, thus paving the path for the application of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European City Squared: Computational Social Science Simulation for Democracy' under Horizon Europe.

assistant: **Concept**

In response to the urgent challenges facing modern democracies, the European City Squared project will use real and synthetic data, along with the latest advances in quantum and classical computational social science, to develop an agent-based computer simulation environment that integrates recent advances in science and technology with social choice theory. This interdisciplinary approach, involving leading scientists, city governments, universities, entrepreneurs, and civil society representatives, will explore the effectiveness of various voting mechanisms, with a primary focus on Quadratic Voting. This novel method of voting has potential to enhance public good allocation and foster an emergent and natural altruism, addressing concerns such as polarization and trust in government.Our methodology will be underpinned by a rigorous adherence to data protection standards, ensuring GDPR compliance and the ethical integrity of our research. By employing mathematical models inspired by natural phenomena, we will identify algorithms conducive to robust democratic decision-making. These algorithms will be tested in real-world scenarios, in collaboration with our government partners, particularly the city of Aarhus, Denmark.The project aims to not only provide groundbreaking insights into democratic governance but also to contribute practical tools for enhancing efficiency and participation in democratic processes. If successful, our research promises to offer significant contributions to the fields of political science, computational modeling, and social choice theory, with the potential to bring unprecedented efficiency gains for European democracies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Oral Vaccination against Clostridium difficile Infection' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Clostridium difficile infection (CDI) is a major threat to public health in the industrialised world, particularly in Europe. In many EU countries C. difficile now eclipses Methicillin resistant S. aureus (MRSA) with hospital acquired infection mortality exceeding that of MRSA by a factor of four. C. difficile is resistant to a wide range of antibiotics with hypervirulent and multiple drug resistant strains now emerging. Vaccines are under development, but all are injectable and as such will elicit only a systemic immune response whereas growing scientific evidence suggests that to effectively prevent infection mucosal immunity is critical. Further, full protection to CDI (primary infection and recurrence) requires anti-toxin antibody responses as well as decolonisation of C. difficile spores. Our approach will be to use a novel mucosal vaccine delivery system based on the use of inactivated Bacillus subtilis spores that express two different recombinant C. difficile antigens on their surface, a toxoid antigen and a unique spore colonisation factor. In vivo proof of concept studies has provided compelling evidence for their use in a robust oral vaccine to CDI. This project aims to construct and optimise B. subtilis spores expressing these two antigens and to undertake therapeutic development. Our approach will use inactivated, killed, spores and oral delivery addressing any ethical issues that might arise. A patent application has been filed protecting this unique oral spore vaccine approach. A consortium has been built of SMEs with the expertise to optimise the therapeutic product and address its safety and immunogenicity in both preclinical and phase I clinical studies. The project will enable a unique oral vaccine against C. difficile to be clinically validated. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metabolomics-driven Molecular Source Analysis for personalized medicine in children', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

While recent advent empowered the new reality of holistic metabolic phenotyping, we are currently still unable to accurately determine the source(s) of the underlying metabolites. This is undoubtedly the main stumbling block in inferring causality to new biomarkers for disease prevention, prediction, and prognosis, particularly given the rapidly increasing burden of metabolic diseases. At the same time, conventional metabolomics methods do not meet the requirements for adoption in clinical practice. MeMoSA will address these issues by unraveling the source hierarchy of the gastrointestinal metabolome, ultimately enabling effective personalized treatments through longitudinal source modulation and follow-up. First, two workflows for 1. high-throughput comprehensive 2D metabolomics and lipidomics and, 2. rapid clinically applicable ambient ionization metabotyping, will be developed. Second, molecular fingerprints of our unique deeply phenotyped pediatric cohorts (1.5k children) will be generated and advanced machine learning algorithms will be used to predict metabolite abundances based on their sources, i.e., diet, lifestyle, anthropometrics, microbiome, drug intake, psychological factors, clinical markers, etc. Third, a combination of in vitro digestions, in vivo humanized mice, and in silico experiments with selected source variables will be designed to contribute to our understanding of source-metabolite causality. These mechanistic insights will be used to build dedicated intervention trials in children with specific source-dominated metabotypes. MeMoSA will lay the foundation for integrating metabolomics into personalized and preventive medicine in children through (i) better prediction of individual metabotypes in relation to health; (ii) in-depth insight into meta