RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing an anti-Myc cell-penetrating peptide for cancer treatment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Despite ever-increasing investments in the development of new treatments, many cancers remain incurable. One reason is that most current therapies target redundant functions around which tumour cells can build resistance. We focus instead on a unique and essential cellular function: the Myc oncogene, deregulated in more than 70% of human cancers. Targeting Myc has long been considered unfeasible because of potentially catastrophic side effects. Against this dogma, using a Myc inhibitor called Omomyc, we showed that Myc inhibition displays extraordinary therapeutic benefit in various mouse models of cancer (e.g. lung, brain, pancreas and skin) and causes only mild and reversible side effects. Importantly, no resistance to Omomyc has been observed, and Omomyc constitutes the best Myc inhibitor known to date. Omomyc has so far been used only as a transgene and proof of principle. However, thanks to the ERC-2013-CoG n° 617473, we now have evidence that the Omomyc peptide has cell-penetrating activity, and reaches lung and brain upon nasal administration, where it exerts its anti-tumorigenic activity in cancer cells (data protected by a patent application EP13382167.8). Thus, the  Omomyc peptide could become the first clinically viable direct Myc inhibitor to treat lung, brain and other types of cancer. Our overall project encompasses the preclinical development of the Omomyc peptide to reach Phase I/II clinical trials, at which point the technology will be transferred to a pharmaceutical company for further commercialization. Hence, in this ERC Proof of Concept application, we propose to achieve specific, essential early milestones for the pharmaceutical development of the Omomyc product that will de-risk it and noticeably increase its value and the probability of reaching
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Learning Environments for the Digital Academy' (LEDA).

assistant: **Concept**

LEDA (Learning Environments for the Digital Academy) will define, develop and test a networked system and the underlying pedagogical procedures to facilitate and promote active learning experiences in the context of international student-centred post-graduate education. LEDA will support the international exchange of learning experiences, research and development - and the project-outcomes thereby stimulating co-operative learning by considering students to be important actors in the learning process. The system will enhance the quality of education in the field of design for digital media by facilitating learning processes that are as close as possible to production processes in the field, thus catering for changing demands from industry and society.LEDA will focus on the exchange, storage and retrieval of articulated learning experiences between students, academic staff and industry, thereby capitalising on knowledge generated by students within research and design programs. LEDA will generate an international knowledge-base on production processes, methods and techniques in the field of digital media allowing institutions of higher education and industry to interactively access research outcomes, product demonstrators, student portfolio's and learning materials.DESCRIPTION OF WORKResearch, carried out in the LEDA program, will provide both educational methodology, procedures and formats as advanced information engineering solutions in the area of multimedia asset storage and retrieval mechanisms. As part of the educational research carried out in the context of LEDA, configurable middleware will be designed which will generate learning environments that meet personal needs in different educational contexts. These environments will be formatted to promote the articula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Graphene-based High Resolution Neural Interfaces for ICT-inspired Neuro-treatment' in the context of a Horizon 2020 call.

assistant: **Objectives**

Electronic devices enabling communication with human nervous system are becoming increasingly prevalent, offering novel information and communication (ICT)-based treatment techniques to help people overcome various disorders ranging from spinal cord injuries (SCIs) to missing limbs. Millions of people worldwide suffer from such ailments with a cumulative cost to the society estimated in billions of Euros annually. Next-generation ICT-based treatment techniques demand for interfaces with higher spatial resolution compared to state-of-the-art. To address this demand, MINERGRACE aims to build a prototype transceiver with high spatial resolution based on nano-patterned graphene sheets (NPGSs), which can be utilised as high resolution neural interfaces (NIs) capable of differentiating and generating highly localised fluctuations in specific ion concentrations. As the project outcome, MINERGRACE will provide a proof-of-concept NPGS-based NI prototype, i.e., a portable electronic device that can be integrated with a microprocessor. High resolution aspects of the MINERGRACE project outcome will provide a very significant improvement to the state-of-the-art in terms of both the capacity of the communication and the complexity of data communicated with the nervous system, enabling the communication with individual neurons. The project outcome will have a wide spectrum of applications involving NIs, e.g., ICT-based SCI treatments and neuro-prosthesis, significantly contributing to their quality of service. Commercialisation process will involve investigation into other commercialisation activities towards other NI products, development of an understanding of intellectual property rights (IPR) positions, and strategies for patenting activities in light of the achieved understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ethical Design of Holography with Dense wireless Networks' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Ubiquitous perception, by sensing of objects, subjects and gestures, is a pivotal challenge for future technology: it enables personalized services such as smart living, automated logistics or interaction through free-space gestures. However, it also challenges ethical and moral boundaries and threatens privacy. HOLDEN proposes a radically new approach to perception by concisely analysing ethical constraints and privacy risks while re-thinking RF-based sensing. We establish necessary conditions for privacy preserving and ethically compliant sensing and develop new paradigms respecting these constraints.For the first time ever, HOLDEN constitutes a concentrated effort to explore social aspects of RF-sensing to guide the technological advance and to derive technology for ethically and privacy compliant perception. Central to HOLDEN is the development of ethical and privacy constraints. We use these findings to derive privacy and ethically compliant concepts for RF-based perception. We will develop a system of distributed multi-antenna devices for simultaneous multi-target recognition and ubiquitous perception with unprecedented accuracy, which constitutes a radical paradigm shift from a technology-centric perspective to a privacy-centric one via privacy by design. HOLDEN achieves this goal along three high risk, complementary, and privacy-centric paths:Path 1: Continuous-space measurement points: Radio-based 3D vision by holographic image processing of RF wave-fronts.Path 2: Discrete-space measurement points: Advanced 3D beamforming for human-scale recognition and tracking through dense massive connected antenna arrays. Path 3: Signal processing and learning: High-dimensional tensor processing for the distinction of complex activities and motion from massive-dimensional R
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Systematic overview (meta-analysis) of all randomized trials of treatment of prostate cancer'.

assistant: **Innovation**

To obtain the most reliable data in the treatment of prostate cancer by conducting a Systematic Overview (meta-analysis) of all randomized trials performed in the field.To put into evidence areas in the treatment of prostate cancer requiring further research.To maintain International collaboration amongst EU investigators in prostate cancer to combine National research efforts, harmonize treatment modalities and stimulate collaboration in large randomized clinical trials.To widely communicate the results to the European medical community.Prostate cancer is the second most common cancer among men in the European Union with over 85,000 new cases diagnosed every year. Treatment for different stages of disease varies widely across EU member states. In the past three decades several therapeutic questions have been studied in randomized clinical trials. In a study performed in 1992, based on medical literature, 155 randomized trials in prostate cancer were identified. The study revealed that the number of patients entered in prostate trials was insufficient (often 50-150 patients per arm) to put into evidence the size of benefits which could realistically be associated with the treatment investigated. Therefore most of the individual trials have not yielded results convincing enough to establish superior treatments or to reliably make a distinction between no worthwhile treatment effect and realistic treatment effects which are essentially moderate. Given the large number of males that will eventually develop prostate cancer, even moderate effects could represent the avoidance of several thousands of deaths in the EU. In the 80's a method proposed by R. Peto, (CTSU in Oxford), known as Systematic Overviews, based on individual patient data (or meta-analysis) was successfully
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High level modelling of high lift aerodynamics', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

In computational predictions of 3D full-size high-lift devices at take-off and landing the accuracy is critical. The accuracy in the modelling of turbulence and transition will be addressed in this study. Transition will be predicted by computing the growth rate of disturbances using database methods, local and non-local stability analysis. Turbulence will be modelled using improved and optimised EARSMs where streamline curvature effects are fully accounted for and the baseline two-equation models are optimised. A coupling procedure between transition prediction and RANS will be developed. The improvements will be demonstrated on 3D high-lift configurations using industrial hybrid CFD codes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research on Core Noise Reduction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In order to achieve the greening of the European air transport with the deployment of low emission and low noise propulsion systems the reduction of core noise plays an important role. The ability to design low core noise aero-engines requires the development of reliable prediction tools. This development demands extensive research with dedicated experimental test cases and sophisticated numerical and analytical modelling work to broaden the physical understanding of core noise generation mechanisms.This objective is only reachable with an extensive cooperation on the European level. In this proposal “Research on Core Noise Reduction (RECORD)” the major aero-engine manufacturers of five different European countries collaborate to enable the design of low core noise aero-engines. In RECORD the fundamental understanding of core noise generation and how can it be reduced will be achieved by combining the research competence of all European experts in universities and research organizations working in this field of core noise. This concept of the RECORD project is completed by the technology development of small and medium size enterprises distributed in Europe.RECORD will promote the understanding of noise generating mechanism and its propagation taking the interaction of combustor and turbine into account. The importance of direct and indirect noise will be quantified. Through carefully designed experiments and extensive numerical calculations, the numerical methods and assumptions will be validated and extended. As a result, low-order models will provide a quick approach for the ”noise design” of combustors and subsequent turbine stages while the more time-consuming and expensive LES calculation will provide a more detailed picture of the flow physics. Finally, RECORD wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Scanning probe microscopy techniques for real time, high resolution imaging and molecular recognition in functional and structural genomics'.

assistant: **Innovation**

High resolution ¡maging of living cells and subcellular components is essential for functional and structural genomics'. Scanning Probe Microscopy (SPM) has evolved into the imaging method of choice that yields the greatest structural details on biological samples such as proteins, nucleotides, membranes and cells in their native, aqueous environment and at ambient conditions. In addition, due to its high lateral resolution and sensitive force detection capability, the exciting possibility of measuring inte r- and intra-molecular forces of bio-molecules on the single molecule level has become possible, leading to new possibilities for the evolution of methods that will enable us to examine the physiological consequences of, even, the interaction of a single l igand molecule with its cognate receptor. In this project we propose to develop Scanning Probe Microscopy to advance the state of the art of this technique. With the support of the Sixth Framework program, Scanning Probe Microscopy is ready to become a mat ure imaging and measurement platform for cell biology that will become as widespread in the biomedicai laboratory as the confocal microscope, adding value to the European scientific instrument market and giving it a major presence worldwide.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BIOPEN'.

assistant: **Objectives**

Nowadays, the center of the bio-based economy is the development of integrated value chains removing sector barriers, where market and product innovations are driven by societal needs and vision of brand owners, and require the collaborations between different sectors through new bio-based value chains (from feedstock to products), also establishing co-operations throughout industry clusters. Open innovation has been identified as the major driver to perform innovation through the flow (in and out) of knowledge, technologies and competences, for organisations to design, plan, and implement market and product innovations as well as to establish sustainable partnerships joining forces with customers, feedstock suppliers, academia, and financial sector.In BiOPEN a consortium highly specialized in the bio-based industry, composed by five European bio-based clusters, three open innovation expert companies, and one research centre, will embark on an ambitious programme to support collaboration and knowledge sharing in the bio-based industry, stimulating the set-up of co-innovation partnerships for the development of new products and markets in the sector.BIOPEN ambition is to become a single voice for the bio-based industries in Europe, gathering expertise and promoting engagement and involvement of industry, researchers and academia at European and national level, by setting up an Open-innovation platform addressing strategic cross-cutting challenges such as (i) clustering and networking to develop new value chains and favour the emergence of co-innovation partnerships across the value chains; (ii)  Stakeholders engagement and support with regards to setting-up at least 20 co-innovation partnerships alongside existing and new value chains; (iii) creation of a knowledge centr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'T cell signal integration in signalling complexes' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The activation of T lymphocytes is governed by the interaction of specific receptor/ligand pairs on T cell and antigen presenting cell (APC), respectively. The engagement of the T cell receptor (TCR) by peptide/MHC complexes on the APC and the interaction ofCD80/CD86 with their costimulatory or inhibitory receptors CD28 orCTLA-4 on the T cell are among the most important. Combinations of the signals are integrated by the T lymphocyte to mount a distinctive response, such as differentiation, proliferation, anergy, or cell death. T cell stimulation induces the formation of signaling protein complexes in the T cell plasma membrane domain in contact with the APC. This study seeks to investigate the effects of modulated T cell activation on the composition of these T cell signalling complexes and to correlate them with functional parameters of T cell activation. In the presence or absence of costimulatory molecules, various peptide/MHC complexes will be coupled to magnetic beads and used for activation of transgenic murine primary T cells. The formation and composition of these signaling complexes will be studied biochemically and by imaging techniques. In this project, I will enter the field of signal transduction. By working on the project, I will complement my knowledge of cell biological, immunological and biochemical methods with state of the art proteomic analysis and analysis of lipid membranes. The host, Thomas Harder, has developed a novel approach for immunoisolationg TCR-containig membrane domains and associated proteins, which will contribute to the understanding of the integration of TCR-mediated and costimulating signals at the level of signaling complexes and might very well lead to the identification of new components of TCR signalling assemblies. In this pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SME Focused KM System to support extended product in ambient intelligence domain (FOKSAI)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SMEs offering already products with AmI elements, intend in a near future (next 1-2 years) to introduce new and/or improve their current products with even more AmI features seeing this as their crucial competitive edge. For such products they need a sophisticated support system. The business objective to be achieved within the FOKSai project is to provide a comprehensive solution of the support to extended products from the ambient intelligence domain, which will be affordable for the SMEs manufacturers (such a solution has to considerably enhance SME business performance by assuring higher acceptance of AmI-products by the customers, reduction of the time and costs needed for customer support (product maintenance, solving customer problems, etc.). Four industrial SMEs having the common needs of extending their AmI-products by product and customer support system, have entered the consortium to launch with three RTD partners the project to develop:A methodology for extensions of AmI-products which will strongly observe business and organisational issues relevant for SMEs.A knowledge based system to support extended AmI-products, which will be affordable for the SMEs manufacturers,The intention is to make this solution general enough to be used for different products and scalable to support the future AmI-products in order to achieve a product (methodology and KM system) which can be offered to a wide spectrum of SMEs intending to introduce AmI -products in their production plans. The customer and product support to be developed will be demonstrated as pilot installations within the environments of 4 SMEs.