RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Axonuclear Communication in Neuronal Growth Control' (NEUROGROWTH), addressing dissemination and exploitation.

assistant: **Impact**

Neurons exhibit the most marked size differences and diversity in intrinsic growth rates of any class of cells. How then can a neuron coordinate between biosynthesis rates in the soma and the growth needs of different lengths of axons? The central hypothesis of this proposal is that neurons sense the lengths of the axonal microtubule cytoskeleton on an ongoing basis by bidirectional motor-dependent axon-nucleus communication, and that the oscillating retrograde signal generated by this mechanism provides input for the coordinated regulation of neuronal biosynthesis and axonal growth. We will test this hypothesis in a multidisciplinary work program that will characterize and quantify the link between biosynthesis levels and axon outgrowth rates and identify and validate the roles and functions of key molecules underlying this mechanism. This research program will elucidate how neuronal biosynthesis and axon growth are co-regulated.  New mechanistic insights on this fundamental aspect of neuronal cell biology will have far-reaching implications. From the basic science perspective, this work will establish a new modality for encoding spatial information in biological signals, providing a one-dimensional solution to the three-dimensional problem of sensing cell size. Moreover, the proposed mechanism can explain intrinsic limits on regenerative neuronal growth and raises the intriguing possibility of opening new avenues to bypass such limits towards acceleration of axonal growth for effective neural repair.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamical barriers, stirring and mixing in geophysical flows. Mathematical models and applications' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Understanding the effects of transport and mixing processes in fluid flows is at the heart of many problems of atmospheric, oceanic and geological sciences. These problems are not only of great scientific interest in their own right, but are also currently of enormous practical importance. Examples include the stratospheric ozone hole phenomenon at high latitudes in both hemispheres, possible mid- latitude ozone depletion in the Northern Hemisphere, long-range transport and chemical transformation of chemical pollutants in the troposphere, the North Atlantic thermohaline circulation and possible future changes in that circulation, with their implications for European and North American climate, the biogeochemical processes controlling absorption of CO2 into the oceans, the existence of geochemical reservoirs in the mantle of the Earth and the generation, evolution and scale distribution of heterogeneities and their possible role in mantle convection.Mathematical models have an important role in atmospheric, oceanic and geological sciences. They provide at framework for quantitative interpretation of data and are the basis for quantitative prediction of future changes. Over the past decade activity in the fields of nonlinear mathematics and mathematical physics has lead to greatly improved theoretical understanding of transport and mixing. One advance, arising out of developments in nonlinear mathematics, has been the identification and investigation of the chaotic advection phenomenon. A second advance, arising in part from the application of methods of mathematical physics to the problem of turbulence, has been improved understanding of the spatial structure and statistics of passive tracer fields in turbulent flows.The above developments have not yet been exploited to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Methods for Real Time 3D tomography in tissue' under Sixth Framework.

assistant: **Concept**

Within this research project, novel and ultra-fast methods for 3D in-vivo imaging will be developed and applied to imaging in tissues and large animals such as mice. In particular, computer codes that extract 3D surfaces, and implement such surfaces for predicating the propagation of light within tissue will be developed. These codes will be used in fast inversion algorithms to provide 3D maps of absorption and/or fluorescence if possible in real time. The computer codes developed will be implemented in a new 3D optical tomography device that the host is at the moment developing, within an Integrated Project in the Fp6 framework for in-vivo Molecular Imaging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Circular Packaging for Direct Food Contact Applications' (2014-2020).

assistant: **Innovation**

CIRCULAR FoodPack aims to facilitate the circular use of plastic packaging addressing the most sensitive product category: Food packaging. This sector contains 87% of all European flexible plastic-plastic multilayer composites (MLC) due to the high requirements for food preservation and safety. However, these MLC laminates cannot be recycled by state of the art processes and thus counteract the circular use of food packaging. Recycled polymers from far less demanding mono-film waste fractions underperform and cannot be used in food packaging, mostly due to the presence of intentionally and not intentionally added substances. We will demonstrate the project results by production of high-quality recycled PE at TRL 5-6, using Sensor-Based-Specification or Tracer-Based-Sorting (TBS, SBS), deinking and thermally assisted deodorization as well as solvent-based or mechanical recycling processes. Innovative designs of recyclable and food-safe mono-material laminates will enable the re-use in high-value film applications, with upcoming food packaging marking with deinkable tracers. This allows a future circular economy of food packaging, if TBS guarantees a sorting of food grade materials. Product characterization, food contact compliance testing, LCA, LCC and business modelling will support and guide process development, upscale and design new packaging. The approach addresses the scope of the call exactly, since innovative sorting and recycling solutions are applied to novel designs being developed. That enables the re-use in the same high-value product sector by removing undesirable substances from secondary raw materials. Addressing the annual 2 Mio tonnes of European MLC food packaging, which currently hamper the recycling of 17.8 Mio tonnes of food packaging waste, the exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LT_OBSERVATORY - OBSERVATORY FOR LR and MT in EUROPE' to be submitted under Horizon 2020.

assistant: **Abstract**

The European Digital Single Market, one of the main goals of Europe 2020, is still fragmented due to language barriers. European society is multilingual, the diversity of its cultural heritage is an opportunity, but hampers transborder eCommerce, social communication and exchange of (cultural) content.  Languages without sufficient technological support will become marginalised. These barriers must be overcome by language technology (LT) like Machine Translation (MT) solutions, a need recognized by the future Connecting Europe Facility (CEF). To support these endeavours to reach an online EU internal market free of language barriers, it is necessary to join, benchmark the quality and facilitate the access to language resources. With this in mind LT Observatory's aims are: - Create a language resource repository stemming from national public sector parallel corpora (taking into account existing ones); check these resources with regard to their quality and benchmark them for most possible reliability and, interoperability including legal and standardization issues.- Identify national and regional funding sources, including Regional and Structural Funds- Continue with a LT News Observatory, started in the LT COMPASS project. - Foster cooperation across stakeholders through targeted dialogue events.- Create a roadmap for future needs to improve the quality of MT and for a high coverage of languages within the Digital Single Market.Based on achievements of former initiatives (e.g. FLaReNet, META), the LT Observatory will be implemented by a team with all the expertise needed: ZABALA (EU project management and with Europe-wide outreach), EMF (ICT Association with experience in outreach/social media, and funding, e.g. ESIF and combined funding), LT Innovate (the Forum of  Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Climate change and risk: Exploring the corporate construction of climate change as risk in different industry settings' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Climate change is one of the most pressing risks facing humanity. However, the way in which climate change is framed as a risk is also critical in shaping the forms of subsequent actions. The proposed Marie Curie Integration Grant (CIG) will enable the integration of Professor Nyberg in setting up a new research program in response to business engagement with climate change. The program's overall aim is to understand how businesses construct climate change as risks and the effect these constructions have on business and society. The succesful integration and research program will: a) develop a new risk based model in explaining corporate engagements with climate change, b) build research networks of academics and practitioners to enhance the research capacity of private and public organisations, and c) inform evidence based public policies for the U.K. and E.U.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'mitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Non-Alcoholic Fatty Liver Disease (NAFLD), including its more pathologic consequence, non-alcoholic steatohepatitis (NASH), is believed to be the most common chronic liver disease worldwide, affecting between 6 to 37% of the population. NAFLD is a so called ‘silent killer’, as clinical symptoms only surface at late stages of the disease, when it is no longer treatable: untreated, NAFLD/NASH can lead to cirrhosis and hepatocellular carcinoma, culminating in liver failure. Currently the best method of diagnosing and staging the disease is liver biopsy, a costly, invasive and somewhat risky procedure, not to mention unfit for routine assessment. Besides, no therapeutic consensus exists for NAFLD/NASH treatment.mtFOIE GRAS (Foie Gras being French for ""fat liver"") proposes to address the pressing need for non-invasive, accurate, rapid assessment of NAFLD/NASH stages, before and after intervention, through the development of biomarkers and innovative tools to follow mitochondrial (mt) dysfunction, a central mediator of fatty liver disease pathogenesis. This promising R&D strategy will also bring new knowledge about the disease mechanisms and improved understanding of the pathogenic process and disease drivers.To that end, mtFOIE GRAS envisages a training-through-work plan that brings together an intersectoral, multidisciplinary team of researchers and technicians experts in their fields, from basic to translational research, clinical practice, technology commercialization and public advocacy. Together with several PhD students, the team will share expertises and work synergistically along the value creation chain to address the unmet medical need of more informative NAFLD assessment. In the process, mtFOIE GRAS will endow the involved staff with excellent scientific knowled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Saturated bioisosteres of benzene  and their application in drug design'.

assistant: **Objectives**

More than 500 of all existing drugs are phenyl-containing organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical approaches towards novel drug-like “chemical space.” In this project, we will address this issue by developing novel saturated bioisosteres for ortho- and meta-substituted benzenes, and incorporate them into several known drugs (intiinflamatory Aceclofenac, antiviral Tipranavir, antihypertensive Oxprenolol, etc) to provide novel patent-free analogues with improved physico-chemical and biological properties.


**Keywords:** benzene bioisosteres,  saturation, photochemistry, bicyclo[1.1.1]pentanes, cyclobutanes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'COMORBIDITY MECHANISMS UTILIZED IN HEALTHCARE' in the context of a Horizon Europe call.

assistant: **Objectives**

The COVID pandemic can be seen as an experiment done with the entirety of humankind (as almost everybody has been or will get infected with SARS-CoV-2). It will therefore have the best coverage over the widest variation possible and is therefore ideally suited to study the effects of infections with SARS-CoV-2 on large quantities of heterogeneous individuals. In our project, we will focus on neurodegenerative diseases (NDDs), namely Alzheimer and Parkinsonism, as the NCDs under investigation.  COMMUTE is a project characterized by the intelligent combination of two fundamentally different approaches: a hypotheses-free, data-driven approach is building on available big data and the application of cutting edge AI/ML technologies to answer the question, whether infection by SARS-CoV-2 causes effects that result in a higher risk for the development of NDDs at population-level. Complementary to that, a hypothesis-driven, knowledge-based approach leverages the substantial knowledge in the scientific community working on NDDs on the putative comorbidity mechanisms linking COVID and neurodegeneration. Both approaches are informing and supporting each other through an intensive crosstalk between computational and experimental biology methods.Understanding comorbidity between COVID and NDDs at causal level is the first goal of the COMMUTE project. The second goal is the translation of the actionable insights into personalized health applications.   On the AI/ML side, the targeted outcome for translation into practice is a set of qualified biomarkers and predictive features that will be used for an AI-powered, model-generated recommender system that will allow for individualized risk assessment and personalized recommendations. On the side of the biomedical assay systems, COMMUTE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Online and Mobile Communications for Emergencies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The SOTERIA Project aims to research and develop recommendations and an associated toolbox that leverage the positive impact of social media in emergencies, enabling public safety organisations (PSOs) and citizens using new mobile and online social media technologies to communicate before, during and after an emergency event, and exchange critical information for the PSOs' intervention in emergency, law enforcement and medical assistance situations.Empowered by the new mobile phones with cameras, text messaging and internet-based applications connecting to social media, citizens expect PSOs to use the same technologies. However, this is not the case. SOTERIA innovates the approach to the dynamics between PSOs and citizens in emergencies, allowing (i) the understanding of the impact social media entails in emergency management systems; (ii) the use of all communication channels in emergency situations, including social media, to the benefit of PSOs and citizens, (iii) the exploitation of mobile platforms’ ubiquity to locate and effectively communicate with citizens in distress and (iv) the leverage of PSOs’ levels of shared awareness and performance, benefiting from citizens’ social media information.Joining companies, universities, research laboratories and a wide community of expert end-users across Europe and beyond, the SOTERIA Consortium is one of the Project’s strengths, having solid competences and experience developing research and development projects. Its ambitious goal is to create recommendations and a professional SOTERIA emergency response toolbox that, respecting the organisational culture of emergency services and the European Union's legislation and concerns on privacy, and considering the related human and technological dimensions, enables PSOs to under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Unravelling the infectome of Candida albicans'.

assistant: **Concept**

The opportunistic human fungal pathogen, Candida albicans causes a wide range of serious disease manifestations, especially in individuals with an impaired immune system. The ability of C. albicans to successfully infect almost every anatomical niche of the human host is both a serious medical problem and an interesting biological property. It is known from in vitro transcriptional profiling that the organism rapidly alters gene expression in response to changing environments; however, very little is known of gene expression patterns in vivo. In addition, a significant proportion of C. albicans genes expressed during infection have no known function. This study will address these two problems in the following ways. Firstly, the transcriptional profile of C. albicans interaction with the host during three distinct models of infection (oral, liver and blood) will be analysed to determine whether C. albicans responds using general transcriptional mechanisms during infection or whether responses are specific depending on the anatomical niche. This transcriptional analysis will then form the basis of a systematic disruption strategy to elucidate the function and role of unknown function genes. Relevant deletion mutants will be generated using a rapid PCR based method and tested for host-interaction using established models of infection. This characterisation will elucidate the function of unknown function genes during infection and describe de novo properties of C. albicans biology. Furthermore, by testing mutants in more than one model of infection it will be shown whether a gene upregulated specifically during one type of infection has significance in another.