RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Next generation precision antibody profiling - from science fiction to reality'.

assistant: **Concept**

One of the major challenges of modern medicine is to understand how the human organism defends itself against invasions and diseases. The biggest mystery is the human immune system, and understanding this ultimately requires knowledge of the sequence repertoire of human antibodies and their respective antigens. The purpose of the TopSpec project is to be the first in the world to solve this challenge, opening up opportunities in medical research and drug development that are today only dreamt about.  We will create a breakthrough technology that will revolutionize academic, clinical and industrial proteomics and dramatically advance the development of new generation antibody- and protein-based therapeutics. Antibodies represent the most sophisticated line of natural defense against disease. Knowing exactly which antibodies are produced in response to a particular disease enables us not only to better understand the cause of the disease but also to provide new-generation cures in the form of personalized therapeutic antibodies.  The limiting factor for this to truly be achieved is to find a way to analyze and sequence large molecules in the gas phase, and this represents a formidable challenge. The TopSpec project will develop ground-breaking TOP-down tandem mass SPECtrometry (MS/MS) approaches based on novel radical gas-phase ion-electron and ion-atom reactions, and implement them on a unique, hyphenated, ultrahigh-resolution MS platform. Another “killer innovation” is the ability to greatly simplify MS/MS spectra of large molecules by adding another dimension of separation – collisional cross-sections of fragment ions using two parallel approaches. TopSpec will be the first project to implement de-convolution of massively overlapping isotopic clusters, solving one of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Merging enantioselective isothiourea catalysis with visible-light photoactivation for the synthesis of biologically-relevant chiral molecules'.

assistant: **Innovation**

The quest for successful lead candidates in drug discovery has challenged synthetic chemists to develop innovative strategies to rapidly generate screening collections of chiral molecules. In this context, cascade processes provide a powerful tool for rapidly increasing, in one step, structural and stereochemical complexity, while fulfilling the requirements for atom and step economy. The development of asymmetric variants has mainly relied so far on ionic reactivity. PHOTO-ITU seeks to expand the synthetic potential of asymmetric cascade reactions to include the radical reactivity domain. To achieve this goal, we will combine asymmetric organocatalysis and photochemistry, two powerful strategies of modern chemical research with an extraordinary potential for the sustainable preparation of novel molecules. Specifically, we will exploit the unexplored excited-state reactivity of isothiourea-based catalytic intermediates thus merging, for the first time, tertiary amine isothiourea catalysis with asymmetric photochemistry. The resulting photochemical asymmetric radical cascades will rapidly generate, in one single step, architecturally complex chiral natural-like compounds containing biologically relevant heterocyclic scaffolds.The planned research combines perfectly the fellow’s experience in isothiourea catalysis and the host’s experience in photo-triggered asymmetric processes to develop otherwise unachievable catalytic asymmetric radical cascade reactions. The resulting strategies will be used as an ideal platform for assembling libraries comprising enantiopure chiral small molecules that, along with biological screening carried out in collaboration with an international pharma-company (Bayer AG), will increase the probability of success in identifying drug-candidate s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The next generation of internet-of-thing (IoT) connectivity.'.

assistant: **Objectives**

The Internet of Things – a vast network of smart objects which work together – is becoming a reality. The number of connected devices is forecasted to reach 50 billion units worldwide by 2020. A wide range of industries – auto makers, healthcare, airlines, banks, smart homes, public institutions or retail giants - are making their products available on various digital platforms. Estimated total IoT market size across all horizontal markets to reach €4.59 trillion by 2018.Today, upon creating an IoT development strategy companies either assemble an internal team that will develop the solution and applications platforms, or outsource the development of a custom built IoT platform to fragmented 3rd party development houses. The process is expensive and fragmented by lacks of standardization or a universal and scalable solution encompassing all aspects of the IoT ecosystem. SoA solutions inhibit IoT development for SMEs and inventors with high entry barrier, prolonged time-to-market and high developmental risks. DeviceHub.net is the first universal, open source ecosystem management platform (EMP) for IoT. We bridge the gap between hardware devices and mobile/web developers by providing a collection of straightforward tools to both ends. DeviceHub is scalable platform that allows SMEs or even single users with little coding or app development experience to create end-to-end IoT solutions with provided hardware, apps for iOS/Android/web and integrated data analytics, i.e. business intelligence (BI) tools, all under one umbrella of DeviceHub, at a fraction of the cost and time of currently available, fragmented solutions.The proposed project addresses the topic SMEInst-01-2016-2017, with the first commercially available, ‘end-to-end’ IoT ecosystem management platform. As a cat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Uncovering and Tuning Correlated Quantum Phases in ABC Graphite on the local scale' (QuantumTuningABC).

assistant: **Concept**

The second quantum revolution targets applications in quantum computation, cryptography, and sensing.  Materials with strongly correlated quantum phenomena as unconventional superconductivity, fractional charge or topologically protected states are promising candidates. In searching for materials with robust and controllable correlated phases, rhombohedral graphite (RG) stands out due to its particularly simple crystal structure. It is readily available, exceptionally disorder-free, tunable and integrable into manufacturing processes. RG consists of individual graphene layers stacked in the metastable, but robust ABC order that naturally leads to a correlated surface state. Indeed, multiple peculiar quantum states have been found in RG, e.g. the fractional quantum anomalous Hall-effect or various unconventional superconducting phases. However, the state-of-the-art samples are limited to thicknesses of 5 graphene layers. This is detrimental, since the electronic density of the correlated flat band increases with layer thickness promising more robust and distinct phases in thicker samples. The Researcher has recently developed methods to reliably fabricate and identify large, perfectly ABC-stacked graphite flakes up to 12 layers. In this project, we will uncover and tune correlated quantum phases in the largely unexplored thickness range of 6-12 layers. The project combines the singular expertise of the Researcher in sample preparation with the one-of-a-kind equipment of the Host. The scanning tunneling microscopy (STM) technique enables the direct mapping, thus visualizing the correlated electronic phases (magnetic or superconducting states, and perhaps fractional quantum anomalous Hall phases) at the atomic scale. This will facilitate the understanding of new quantum ph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Surface modulation of wounds: heal by inhalants! Novel drug-based treatment for excessive scars and chronic wounds.' under Horizon 2020.

assistant: **Concept**

The innovative concept of the ERC Starting Grant project “Keratinocytes and Matrix metalloproteinases: driving force of skin wound contraction?” was to use inhalants for skin wounds and it proved to be excellent and functional. Surface Modulation of Wounds (SUMOWO) with these anti-inflammatory, pro-migratory and anti-fibrotic compounds will be beneficial for chronic wound healing and reduce excessive scarring. This novel drug-based treatment strategy marks a novel era of wound care. A clinical phase 1 study on healthy volunteers is planned to show the product’s safety and tolerability for skin use – the first step towards clinical application. The goal of SUMOWO is to deliver clinical proof of concept, to provide a thorough market analysis with contact to key-players, to secure our intellectual property rights on an international platform, to accelerate commercial exploitation and ultimately, to restore patients’ life quality.


**Keywords:** excessive scarring, chronic wounds, leg ulcers, wound healing, surface modulation, scar prevention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of two-dimensional transition metal compound based efficient electrocatalyst for green H2 production' (2DTMCH2) targeting Horizon Europe.

assistant: **Abstract**

The rapid progress in intermittent solar, wind technologies has created an urgent need to develop parallel technologies of storing energy in forms that are suitable for on-site applications as well as long distance transmission. The present method of storing the surplus energy in batteries is not a viable solution in the long run, owing to the limited reserves and toxicity of battery materials. In such a scenario, storing the obtained energy in the form of H2 fuel is a fairly attractive strategy. Alkaline water electrolyzer (AWE) have been a key technology for large-scale hydrogen production and are capable of generating energy in MW range. Alkaline water electrolyzer (AWE) still requires technological make-over to reach the desired efficiency of about 90 % from the current 70 %. On the other hand, counterpart technology of proton exchange membrane (PEM) water electrolyzer is highly efficient, but its investment cost and low lifetime limits commercialization. The investment cost of AWE today is around 1000-1200 $/kW, and PEM is 1700-2500 $/kW. In addition, the lifetime of AWE is higher and the annual maintenance costs are lower compared to PEM. Although AWE has an economic advantage over PEM, integrating AWE with an intermittent energy source of solar and wind power requires a major advancement in the design to be used in dynamic operating conditions.  The key objective of this research is to develop a multipurpose low-cost water electrolyzer for H2 production by electrolysis of alkaline-water with special focus on seawater (alkaline) water to store intermittent energy sources (solar and wind) in form of clean fuel. Unfortunately, there are no commercial electrolyzer that run on seawater, owing to the associated research and technical challenges of high activity, OER se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biomimetic collagen-based scaffolds for the study of pancreatic cancer and delivery anti-tumoural miRNA for enhanced cancer therapy.' to be submitted under Horizon Europe.

assistant: **Abstract**

Pancreatic tumours are among the most aggressive, and are associated with the lowest survival rates. The main reason of this is their characteristic dense fibrotic stroma, which creates a perfect environment to promote cancer progression. To accurately mimic the Extracellular Matrix (ECM) is challenging, but is essential to understanding the interaction that occurs during malignant transformation. KRAS mutation is the most frequent alteration in pancreatic cancer. Micro(mi)RNA-143-3p and miRNA-216b have been shown to decrease KRAS gene expression and suppress tumour cell growth. My overarching Aim is to generate a 3D model of pancreatic cancer in which I can test the ability of a miRNA-activated scaffold to suppress tumour growth and facilitate local delivery of miRNA (miRNA-143-3p and miRNA-216b) that downregulate KRAS expression. Prof. Fergal O’Brien’s group in Royal College of Surgeon in Ireland has an extensive experience with development of biomimetic scaffolds to recreate the tumoural ECM and activating scaffolds to release therapeutic molecules (e.g., miRNAs). Using techniques established in his group, I will develop a 3D collagen-based scaffold that recreates the structure of pancreatic tumour ECM and then utilise this form as miRNA-activated scaffolds that will be used as local delivery systems in a radical new treatment for this disease. I will be supervised by Prof. O’Brien, and he will guide my Career Development Plan. I will develop complementary skills in project management, leadership, entrepreneurship, commercialisation, dissemination, and profile enhancement. Acquiring advanced research competences and complementary skills, I will maturate as an independent scientist, enhancing my professional visibility, capacity, and competitiveness in the field of bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Self-Optimising Modular Control Software for Small Hydro Power Plants' (HYDROMAX).

assistant: **Innovation**

- To develop, optimise and test a new control strategy for the optimisation of the electricity production of small hydropower plants;- to simplify and optimise the procedure of finding the best-performance-curve of a double regulated turbine;- to develop and test methods how to achieve the best performance from a set of turbines (multiple unit installations) using a self optimising algorithms;- to develop a graphical user interface for the adaptation and programming of the control software for the individual site, avoiding programming language skill for the manufacturer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epidemic intelligence to minimize 2019-nCoV’s public health, economic and social impact in Europe', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EpiPose aims to provide urgently needed answers about the epidemiological characteristics of 2019-nCoV, the social dynamics of the outbreak, and the related public health preparedness and response to the ongoing epidemic, as well as to assess its economic impact. The consortium consists of 6 partners in 5 countries (BE, NL, UK, CH, IT) who provide complementary expertise in mathematical and statistical modelling of infectious diseases, participatory surveillance systems, living systematic reviews, and health economic analysis and have a strong international public health network.  EpiPose aims at a quick delivery of results, according to the following objectives:  (1) To collect and share epidemiological data of 2019-nCoV as widely as possible  (2) To provide country-specific estimates of key epidemiological parameters  (3) To model the expect impact of 2019-nCoV on morbidity and mortality  (4) To monitor awareness and behavioural change during the 2019-nCoV epidemic  (5) To provide health economic analyses for interventions within the EU  (6) To foster the interaction between the scientific community, public health agencies and the public  EpiPose aims to make all research data, code, tools and results publicly available and its dissemination plan targets active communication and interaction with policy makers, other scientific groups and the general public. As such, the epidemic intelligence provided by EpiPose will help minimize the 2019-nCoV’s public health, economic and social impact.


**Keywords:** 2019-nCoV, Coronavirus, mathematical modelling, statistical modelling, behavioural change, public awareness, health economics, public health, now-casting, forecasting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Beta-cell Receptors in Diabetes Therapy'.

assistant: **Objectives**

This Fellowship combines the expertise of the host group in the expression and function of islet G protein-coupled receptors (GPCRs) with the Fellow’s previous experience in identifying the role of retinoic acid and neurotrophin receptors in islet function. GPCRs are the targets of up to 50% of all prescription drugs and Byetta, a GLP-1 receptor activator used to treat Type 2 diabetes (T2D), provides proof of concept that ligands targeting islet GPCRs may be developed for T2D therapies. However, Byetta has been associated with pancreatitis and kidney dysfunction, so there is a need for novel T2D therapies with minimal side-effects. There are over 50 million people in Europe with T2D, which arises when insulin secretion is unable to compensate for insulin resistance in target tissues. Agents that increase insulin secretion and/or stimulate b-cell proliferation will have beneficial effects in T2D where insulin secretion is compromised through impaired stimulus-secretion coupling and/or reduced b-cell mass. This Fellowship project has two main objectives: Investigating the role of islet short chain fatty acid receptors (FFAR2 and FFAR3) in regulating beta-cell function and identifying novel islet GPCRs that regulate insulin secretion and/or beta-cell mass. The host lab has identified expression of FFAR2/3 by islets and the Fellow will determine whether they have therapeutic potential for the treatment of T2D. In addition, orphan GPCR beta-arrestin reporter cell lines will be used to detect activating ligands secreted by islets and functional effects of those orphan GPCRs will be established following knockdown of their expression. This is an ambitious project that has the potential to provide drug discovery leads for T2D therapies. The Fellow will benefit from training in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Contribution of tRNA fragments in the ETiopathogenesis of Huntington's Disease (tR-GET HD)' under Horizon Europe.

assistant: **Concept**

Many pathogenic mechanisms are involved in Huntington’s disease (HD), the most prevalent monogenic neurological disease in Europe, with no current cure. The host team reported a dysregulation of tRNA-fragments (tRFs) in HD brains; other studies showed higher stress granules' (SG) density in HD, and that tRFs promote SG assembly. Thus, my hypothesis is that HD-related tRFs contribute to the accumulation of SG, initiating mutant huntingtin (mtHTT) aggregation and leading to disease pathogenesis. I propose to explore the interaction between mtHTT aggregates, and tRFs and SG, as new potential therapeutic targets. Specifically, I aim to study the 1) cell-type specificity of tRFs formation and their correlation with HD progression; 2) molecular mechanisms by which tRFs may induce HD pathology; and 3) potential of tRFs modulators to treat mtHTT-related neurotoxicity.This project’s success relies on the perfect synergy of the host team’s expertise in tRFs biology and HD and my own experience in RNA and proteotoxicity in neurodegenerative diseases, thoroughly addressing the hypothesis via complementary human, cellular and mice HD models and a plural array of bioinformatic, molecular biology and genomic approaches. The outcomes will help define the role of tRFs and SG in mtHTT aggregation, and may be used as preclinical proof-of-concept for novel HD therapies, reflecting the project’s translational potential.I will benefit from scientific exchanges with expert neuroscientists in the host institution, particularly my supervisor, whose skills in functional genomics fully match my expertise in RNA and protein pathological mechanisms. My translational technical knowledge and network of collaborators will be useful to the host group to build new cooperative projects. Thus, the MSCA fe