RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Defective protein translation as a pathogenic mechanism of peripheral neuropathy'.

assistant: **Concept**

Familial forms of neurodegenerative diseases are caused by mutations in a single gene. It is unknown whether distinct mutations in the same gene or in functionally related genes cause disease through similar or disparate mechanisms. Furthermore, the precise molecular mechanisms underlying virtually all neurodegenerative disorders are poorly understood, and effective treatments are typically lacking.This is also the case for Charcot-Marie-Tooth (CMT) peripheral neuropathy caused by mutations in five distinct tRNA synthetase (aaRS) genes. We previously generated Drosophila CMT-aaRS models and used a novel method for cell-type-specific labeling of newly synthesized proteins in vivo to show that impaired protein translation may represent a common pathogenic mechanism.In this proposal, I aim to determine whether translation is also inhibited in CMT-aaRS mouse models, and whether all mutations cause disease through gain-of-toxic-function, or alternatively, whether some mutations act through a dominant-negative mechanism. In addition, I will evaluate whether all CMT-aaRS mutant proteins inhibit translation, and I will test the hypothesis, raised by our unpublished preliminary data shown here, that a defect in the transfer of the (aminoacylated) tRNA from the mutant synthetase to elongation factor eEF1A is the molecular mechanism underlying CMT-aaRS. Finally, I will validate the identified molecular mechanism in CMT-aaRS mouse models, as the most disease-relevant mammalian model.I expect to elucidate whether all CMT-aaRS mutations cause disease through a common molecular mechanism that involves inhibition of translation. This is of key importance from a therapeutic perspective, as a common pathogenic mechanism allows for a unified therapeutic approach. Furthermore, this proposa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Elucidating the role of liver resident Kupffer cells in the regulation of the immune responses to intestinal antigens' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The liver is constantly exposed to intestinal material via portal blood circulation and thus it has long been implicated in the modulation of systemic immune responses to intestinal antigens. Despite this, the precise cells involved and the molecular mechanisms at play are largely unknown. Liver resident macrophages termed Kupffer cells (KCs) are ideally located within the blood stream of the liver sinusoids to encounter intestinal antigens. We hypothesise that KCs acquire intestinal antigens and subsequently modulate the immune response to these. Despite indications that KCs are involved, the lack of KC-specific tools has significantly hampered the study of these cells and to date their physiological role in modulating immune responses to intestinal antigens remains unclear. Here we propose to utilize novel and innovative tools including KC-specific knock-in (KI) mice generated by the host lab to specifically examine the role of KCs in antigen acquisition, presentation and determination of T cell fate. To our knowledge these tools represent the first of their kind and place us in a unique position to specifically examine the role of KCs in regulating the immune response to intestinal antigens. By combining murine modeling with analysis of human tissues in collaboration with the University Hospital, this project will greatly advance our understanding of the role of KCs and potentially uncover new therapeutic strategies in the prevention and/or treatment of disorders where the systemic immune response to intestinal antigens is dysregulated such as food allergies and inflammatory bowel diseases (IBDs).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '3-Dimensional Reconstruction of Catalysts by Scanning Transmission Electron Tomography' under Sixth Framework.

assistant: **Concept**

The use of modern catalysts requires the fabrication and knowledge of nanometre-sized particles whose catalytic efficiency depends upon not only their chemistry but also their topology both in terms of the particle size and shape and also their distributio n within the support. In Cambridge, there has been enormous advances in the synthesis and characterisation of heterogeneous catalysts consisting of bimetallic nanoparticles distributed within a silica mesoporous framework. The development of such catalyst systems depends critically on a knowledge of how the particles are distributed in three dimensions within the framework. Conventional electron microscopy whether in TEM or STEM mode will give only a projection of this structure and whilst this can give ext remely valuable information it does not reveal the full picture. Electron tomography has been developed to investigate (using only bright field images) the three-dimensional structure of viruses, macromolecules and so on. In this proposal, the aim is to us e the high angle annular dark field signal recorded under STEM illumination to investigate the 3-dimensional distribution of the nanoparticles. This kind of images are directly interpretably, are not plagued by phase contrast and be recorded quickly and ef ficiently in a modern analytical instrument. The installation of such a technique will be used to study a number of catalyst systems devoted mainly to nanoparticles of cobalt and of cobalt-iron and cobalt-gold on various light supports, such as mesoporous silica. The importance of cobalt as a powerful Fischer-Tropsch catalyst can hardly be over-emphasised. It is profoundly important if the cobalt co-exists (in a bimetallic entity) with either iron, or ruthenium (or with certain noble metals).The development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovation Support Network East Mediterranean', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Aim of the project is to become a true one-stop-shop for business and innovation support along the entire value chain,providing its services in the proposed region the context of COSME and HORIZON 2020 Programme and in line withthe Europe2020 strategy. innovation support services will helpstrengthen the competitiveness and sustainability of regional enterprises.Proposed project will include two acitivity type which are “Key account management under the SME Instrument ofHorizon 2020” and “Services to enhance the innovation management capacities of SMEs”


**Keywords:** Innovation Management, Innovation Support, SME Instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PERSONAL ADAPTIVE MOBILITY AID FOR THE FRAIL AND ELDERLY VISUALLY IMPAIRED' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Over 65% of all blind people are over 70 years old, and with increasing age, infirmity prevents the use of common mobility aids such as long canes and guide dogs, and often confines them to bed for their own safety. This results in rapid deterioration of their mental health and the cardio-pulmonary system. The PAM-AID intelligent mobility aid enables users to regain personal autonomy, avoiding complete dependence on carers. This navigational and physical support warns of and avoids obstacles ahead, and has three levels of use. Under human control the system simply issues warnings of obstacles detected, only intervening if grave danger threatens. With unsupervised control the system navigates, avoiding obstacles within its sensor range. With shared control the system minimises the risk of collision by making small adjustments to the user's path. The device is sensitive to both static and moving obstacles/risks, and users can switch freely between modes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mate choice and song complexity in the willow warbler' under Fourth Framework.

assistant: **Concept**

It is currently accepted that song complexity in birds has evolved partially by female preference. Although there is good evidence for this preference from laboratory experiments, most field studies have failed to show strong correlations between song complexity and female choice. It has been suggested recently that this may be due to the fact that the measures of reproductive success have not taken into account the extra-pair paternity that some males may achieve.  The study for which this scholarship is requested will examine how repertoire size relates to mate choice and reproductive success in the Willow Warbler (Phylloscopus trochilus), a species which shows very high variability in repertoire size. The project involves the measurement of several aspects of song complexity in a colour-ringed population, and the comparison of these characteristics with the mating success of the different males. DNA fingerprinting will be used to assess the extra-pair paternity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TRial of Intelligent Tag ON industrial environment' under Fifth Framework.

assistant: **Concept**

The objective of this project is the implementation of a Trial Application in a real production environment (cleaning products manufacturing) using the TagFlow system. This system is the result of an Esprit project named ALBATROS, whose objective was the development of an intelligent Tag based on RFID technology for the Retail sector. The project will be accomplished by a collaboration process between IECISA-technology provider and -P&G-user. IECISA has consolidated the results of ALBATROS into a system named TagFlow that includes several types of subsystems (Tags, Readers, Antennas, Commutation Devices, Firmware, Low level Protocols, etc.). Objectives:The objective of TRITON is the implementation of a Trial Application in a real production environment using the solution TagFlow. This solution based on a RFID intelligent Tag was developed for the Retail sector and will be applied for the first time in a production environment. The user of the Trial has identified this solution as the best to improve some essential aspects in its production processes. The technology provider would like to extend the functionality of the system to a different sector in order to test and improve its capabilities. The innovation aspects of this trial are: adapt a leading edge technology (developed for Retail) to another sector with a more significant potential growth at short term; install the system in a critical mission and real time process; transform the buggy into a live buggy (opening added value possibilities in the proceeses). Some goals identified by the user are: reduce error rate in production, increase automation degree, real time inventory.Work description:In order to reach the proposed goal, we have to achieve some partial objectives. The project has been structured in two pha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extended University Alliance Doctoral Training Alliance in Energy, Applied Biosciences for Health and Social Policy DTA3' (DTA3) targeting Horizon 2020.

assistant: **Abstract**

The DTA3 will develop 83 early-stage researchers (ESRs) as internationally connected, independent researchers with interdisciplinary and inter-sectoral skills and experience, ready for industrial employment in the European and UK priority challenge areas of healthcare, clean energy and social policy.  Building on existing individual doctoral programmes, DTA3 is delivered through a consortium of 12 universities across England and Wales, with associate partners in Europe and Australia. COFUND will support the full integration of three existing individual programmes of training in applied biosciences for health, energy and social policy. This will increase the employability gains for graduate ESRs, who will benefit both from deep subject expertise and a broad understanding of the global challenges in these three key sectors. This responds to identified employer needs and will enable ESRs to transfer quickly and easily into a range of industry roles across the globe after their study.DTA3 provides access to expertise and research equipment across 12 institutions and an additional layer of cross-disciplinary training opportunities. ESRs will graduate from the programme with a solid grasp of the context of their skills and knowledge in the global labour market, and an international professional community of peers and employer networks. Thus, the over-arching ambition of DTA 3 is the development of a mobile, interdisciplinary and international ESR community able to solve grand challenges by working across healthcare, energy and social policy sectors. It seeks to build a cohort with broad connections to professional networks, industry and commerce across these three key sectors. Core objectives have been identified:- Development of a mobile, interdisciplinary & international ES
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stereocontrolled synthesis of polypropionates based on building block assembly strategies by lithiation-borylation methodologies' under Horizon 2020.

assistant: **Concept**

Amongst all natural products, polyketides constitute a very important class due to their broad spectrum of biological activities (eg. antibiotic, antitumoral, antifungal, antiparasitic). Many of these compounds are referred to as polypropionates, which are characterized by sequences of methyl- and hydroxy-bearing stereogenic centres, enabling large numbers of possible stereochemical permutations. The importance of these natural products as therapeutic agents and as biomedical tools together with their structural complexity has made these molecules attractive targets for synthetic organic chemistry. The key to construct these systems, which posses a high level of stereochemical information, is the control of the absolute and relative stereochemistry of each centre. Herein we propose the development of a novel and general strategy for the synthesis of any polypropionate-like molecule based on the construction of a building block assembly platform. This process will capitalize on the well-established lithiation-borylation methodology so complete control of both relative and absolute stereochemistry of all chiral centres will be achieved. The power of the strategy will be demonstrated in the synthesis of the polypropionate core of the antibiotic Streptovaricin U. The successful development of this research will shortcut the synthesis of stereochemically defined polypropionates combining building blocks of varying length. Moreover, the possibility to modify the stereochemistry of any centre will allow access to all known natural polypropionate fragments and will permit the preparation of non-natural analogues too. The development of such an ambitious and innovative project in the University of Bristol will be facilitated by generating, transferring, sharing and disseminating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '5th congress of the european foundation for plant pathology : biodiversity in plant pathology' under Fifth Framework.

assistant: **Concept**

Sepal has been asked by the EFPP to organise the 5th EFPP Congress devoted to Biodiversity in Plant Pathology. Four main sessions are foreseen in order to bring up the state of the art in the study of pathogens and plant response to infections as well as new control strategies preserving the environment and improving the safety. The Congress is aimed also to evaluate the potential of biotechnologies in Support of community policy in the context of sustainable agriculture. The large expected audience (ca.500 people from 30 countries) gives the opportunity to organise a concluding panel session on the Highlights of the European research for a friendly development and integration of technologies. A book of abstracts and the proceedings of the Congress will allow the information of scientists. The final resolution will be disseminate throughout magazines, journals and newspapers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring magnetic quantum phase transitions with ultra-cold Fermi gases' under Seventh Framework.

assistant: **Concept**

The project “Exploring magnetic quantum phase transitions with ultra-cold Fermi gases” (MAG-QUPT) aims at developing a novel platform for the experimental exploration of quantum phase transitions and quantum critical phenomena using ultra-cold atomic gases. As envisioned by R. Feynman in 1982, and successfully demonstrated in the last years, these systems can be used to emulate fundamental quantum collective phenomena and constitute ideal test-beds for deepening our understanding of quantum-many body physics. By providing novel insights into long-standing open questions of condensed-matter physics, they pave the way towards the development of new materials and quantum devices. The ambitious goal of this research project is to establish a novel toolbox for the controlled study of magnetic quantum phase transitions based on ultra-cold quantum gases, going beyond the capabilities currently offered by solid-state systems. To this end, we will exploit the unique properties of ultra-cold Fermi gases trapped in optical lattices of adjustable geometries. Building-up on our previous work, we will implement paradigmatic spin models for magnetic quantum phase transitions in this setting, and develop novel tools for their characterization. More precisely, this research proposal introduces two main objectives: i) the development of an experimental apparatus specifically adapted to this goal. ii) the experimental observation and characterization of a prototypical magnetic quantum phase transition, and the study of the corresponding quantum critical regime. Reaching these objectives would demonstrate a new frame for the experimental exploration of quantum critical phenomena. This would open new horizons for our understanding of the fundamental connections between quantum many-body phy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative single-cell RNA-seq kit to support large democratization of insgle-cell analysis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This project will develop and perform the industrial scale-up of a game-changing scRNA-seq tool named DEEP-IN-CELL. This solution, in a kit format plus a cloud software analysis suite, will use the proprietary hydrogel-based RevGel technology of Asteria kit as a basis for a new generation of kit that ambitions to dramatically simplify access to single-cell studies with a shorter time to result, far easier, robust and authentic transcriptome-preserving technology multiplied by reducing cost per sample. This new generation of kit shall bring a similar revolution to the single-cell market as did the Qiagen RNA extraction kit in its time to the genomic market, while providing performances at par with that of the market gold standard and monopolistic costive instrument-based single-cell technology 10xGenomics. This next generation of single-cell RNAseq kit is expected to first launch in late 2024 with first applications to the international single-cell research market and to generate sales exceeding €50M by 2029. It is foreseen to become the quintessencial single-cell RNAseq kit that will open access to single-cell studies to a much broader research community.


**Keywords:** sequencing data analysis,clinical diagnostics,cellular rare events,single-cell analysis,precision medicine,genomics,epigenetics,proteomics,transcriptomics,single-cell barcoding,scRNA-seq,cell clustering,hydrogel technology