RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure and Function of the Dynein Tail' to be submitted under Seventh Framework.

assistant: **Abstract**

Movement is a defining characteristic of life at the sub-cellular level. Dynein is one of the motor proteins that power this movement. It carries a wide range of cargos and dynein dysfunction has been implicated in many human diseases. Unlike other motors only one cytoplasmic dynein exists which suggests that it has unique mechanisms for controlling specificity i.e. how it carries cargo to the right place at the right time. In order to understand these mechanisms detailed structural knowledge of the cargo interacting dynein tail will be essential.We propose to study the structure dynein tail by achieving three independent objectives. 1) Obtain the crystal structure of the yeast dynein tail. To do this we will combine a plasmid based S. cerevisiae expression system developed at our institute with advanced fermentation techniques. 2) Recombinantly express mammalian dynein tail complexes for single particle electron microscopic analysis and biochemical characterization. This will be achieved using novel molecular biological techniques for expressing protein complexes combined with cryo-EM. 3) Analysis of viral interactions with dynein. This will be achieved by reconstituting dynein/virus movement in vitro and subsequently analyzing dynein/virus complexes by EM tomography.Together these approaches will allow us to analyze the structure and function of the whole dynein tail complex to gain insight in dynein/cargo specificity for the first time. This innovative project will significantly strengthen European science by serving as an excellent starting point for many new and groundbreaking lines of research. Furthermore, it will allow the applicant move to a different European country as well as switch fields of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Engineering of a minimal bacterial therapeutic chassis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Engineering bacteria to deliver therapeutic agents or to present antigens for vaccination is an emerging area of research with great clinical potential. The most challenging issue in this field is the selection of the right bacteria to engineer, commonly known as “chassis”. The best chassis depends on the application but there is a common drawback in bacteria used nowadays: their complexity and the lack of quantitative information for many reactions which limits genome engineering to classical trial and error approaches.  In this project, we want to engineer the genome-reduced bacterium M. pneumoniae using a whole-cell model that will drive the rational to create a chassis for human and animal therapy. Its small size (816 Kbases), the lack of cell wall, and the vast amount of comprehensive quantitative –omics datasets makes this bacterium one of the best candidates for chassis design. By combining bioinformatics, -omics, and biochemistry approaches with genome engineering tools, systems biology analyses, and computational whole-cell models, MYCOCHASSIS aims to: i) develop a whole cell-model based on organism-specific experimental data that will be validated experimentally and that can predict the impact of genome modifications; ii) implement genome engineering tools to delete non-essential pathogenic and virulent elements predicted by the whole-cell model to engineer a therapeutical chassis; iii) using the whole-cell model design and engineer genes and circuits to improve growth rate in a defined medium. iv) as a proof of concept introduce orthogonal gene circuits to secrete peptides and enzymes capable of dissolving in vitro biofilms made by the lung pathogens Pseudomonas aeruginosa and Staphylococus aureus. This project will validate the usefulness of whole-cell model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'eMOTIONAL Cities - Mapping the cities through the senses of those who make them' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

As the world is becoming more urbanized and cities of the future need to be people-centred, robust evidence-based knowledge on the underlying biological and psychological processes, by which Urban Planning & Design influence brain circuits and human behaviour, will be critical for policy making on urban health. Emotions are key drivers of our decisions; similarly, our choices are the conduit for our well-being and health. Thus, research focusing on the signals triggered in our neurobiological architecture, responsible for emotions and decisions, while humans interact with the urban environment will shed light on how to improve population health, physical and/or mental. The eMOTIONAL Cities project was designed to fully characterise the intensity and complexity of urban health challenges and inequalities. By exploring the mechanisms and their dynamic, it complements conventional descriptive perspectives focused on exposure-outcome associations. It adopts a systems approach, based on natural experiments and actual problems of case-study cities (Copenhagen, Lisbon, London; and Lansing/Detroit in the USA). Building on theoretical foundations, novel eMOTIONAL city mapping will be generated by combining spatial analysis on social/health data with neuroscience experiments. Our research relies on mixed (qualitative/quantitative) methods and uses multidisciplinary instruments from Urban Planning & Design (GIS for land use, transport, climate and health), Neuroscience (fMRI, EEG) and Data Science & Technology (AI, Big Data and VR/AR reality). The analysis also addresses gender aspects and contemplates a clinical study to show that urban design can impact a vulnerable elderly population at risk of developing dementia. Finally, a novel machine-learning scenario discovery framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthetic Viral Nanosystem for Highly Efficient AAV Manufacturing for Gene Therapy' (AAV-FACTORY) under Horizon 2020.

assistant: **Objectives**

Gene therapy is one of the most innovative and fastest growing fields in the pharmaceutical industry. The first approved gene therapy utilized a recombinant AAV vector (rAAV), and dozens of additional rAAVs for gene therapy are presently in clinical trials. rAAV gene therapy drugs have been priced in the region of € 500’000 and above, which is partially a result of them being manufactured by highly complex processes combining multiple components, requiring 5-7 separate GMP production runs. We intend to introduce the first scalable, single-virus rAAV production platform to resolve this bottleneck. The resulting significant reduction of manufacturing complexity will both lower the price of future rAAV gene therapies, and also deliver additional, currently unaddressed or unaffordable rAAV treatments for genetic diseases into the clinic by providing scientists operating at the laboratory R&D stage with more user friendly and productive tools. The proposed project also develops for PoC purposes an rAAV gene therapy candidate to treat the devastating childhood congenital disease known as steroid resistant nephrotic syndrome SRNS.


**Keywords:** Adeno Associated Virus AAV, Viral Vector, Gene Therapy, Synthetic Viral Nanosystem SNV, Recombinant Production, Manufacturing, Upscaling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LUnga notte della Ricerca - Lange NAcht der Forschung' (2014-2020).

assistant: **Concept**

Neither the promotion of science and research nor innovation are a priority in South Tyrol, a land of around 500,000 inhabitants. Traditions are agriculture, skilled crafts and trades. Only 0.7% of South Tyrol’s gross domestic product is spent on research and development, compared with 1.26% in the whole of Italy and 1.63% within the EU. (Source: Istat 2015, OECD 2015). Those committed to promoting research in the region try to engage both politicians and the general public by means of a wide variety of activities. One particularly important crowd puller is the biennial ‘Long Night of Research’ (Lunga notte della ricerca – Lange Nacht der Forschung) in Bozen-Bolzano. The EURAC – unibz – TIS consortium together with other partners will be opening their doors for the fifth time on September 30th, 2016, allowing visitors the opportunity to have a proper look at the work of the scientists, to enter into discussions and conduct experiments with them, to be amazed and to have fun. The three main venues for events in Bozen-Bolzano will as before be linked by a free shuttle bus service which will also serve the locations of up to 8 further events partners. The Awareness Campaign will target around 300,000 persons. The ever growing visitor numbers of the previous events (in 2014 the record number of almost 16,000 visitors was reached!) suggests that we should expect around 15,000 interested individuals keen on joining us. This year’s theme is “The Big Picture”, and from 17:00 onwards, young and old will be able to see for themselves that South Tyrol’s researchers play their part in contributing important pieces to the jigsaw puzzle which will enable them to anticipate or to influence future developments in the big picture that is Science. Interactive stands, competitions, games,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Simulation and test of ideal glass model' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

There probably exist more theories for the glass transition than for any other phenomenon in condensed matter physics except high-Tc superconductivity. Some of these theories assume that the glass transition reflects an underlying (possibly frustrated) thermodynamic phase transition; others describe the glass transition as a purely kinetic phenomenon. It is important to disentangle, as much as possible, the roles of structural correlations and purely kinetic effects in the absence of such correlations.  Recently, Prof. Frenkel's group developed a model for glass-forming fluids that has the structural properties of an ideal gas. If this system undergoes dynamical arrest, it is a purely kinetic effect. Surprisingly, no earlier studies of ideal, off-lattice glass formers exist. In view of the present proliferation of theories for the glass transition, we believe that a careful and systematic study of the Sideal glassa is both necessary and timely. We propose to study the properties of this model glass by molecular dynamics simulations. By comparing the properties of this system to those of a typical aSstructurala glass former, we aim to provide quantitative data that can be used to test the underlying assumptions of existing theories for the glass transition. Ultimately, we hope that our simulations will allow us to make unambiguous statements about the limits of applicability of existing theoretical models for the glass transition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ACCelerating EuropeaN Deeptech scale-ups' (ACCEND).

assistant: **Innovation**

The overarching goal of ACCEND is to establish capabilities and processes that enable the project partners to conduct impactful and exemplary cross-border startup accelerator programmes in Europe - to initiate and establish a long term cross-border startup acceleration service ecosystem. It brings together and enriches a diverse and complementing array of deep tech acceleration services: support in access to finance; advisory in the use of testbeds and living labs for business development; matchmaking with key public procurers of innovation; and global growth coaching advisory targeting global scaleup pathways with go-to-market activities.ACCEND builds shared understanding and trust between the project partners by collaboratively designing joint, distributed Cross-border Startup Accelerator Services that builds on strengths, weaknesses, opportunities and threats of each partner and their regional ecosystems; It conducts a pilot programme named ACCEND Accelerator where these complementing services are delivered to a 100+ scale-up companies, aiming towards opening the regional services and funding borders, as well as global markets for these startups. To conduct this successfully, it connects the startup services ecosystem in the partner regions more widely, to leverage local and European initiatives, and to anchor the cross-regional collaboration. The project's ultimate goal is to validate a sustainable model for continuous cross-border Deep Tech acceleration services deployment.


**Keywords:** Deep tech, Acceleration, Cross-border, Innovation Ecosystem, Growth Coaching, Investments, Access to Finance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Training Network for the education of the next generation scientist in targeting the supressive capacity of regulatory T-cells specifically within tumours'.

assistant: **Objectives**

Tumour immune-therapy has made dramatic improvements in recent years, saving the lives of cancer patients who just afew years ago would have been considered untreatable. It thereby became apparent that one specific type of immune cell,so called regulatory T-cells, critically hampers the efficacy of tumour immune-therapy. Tumours, however, attract and exploitthe immune-regulatory function of Tregs to dampen local immune responses and to induce local tolerance.In recent years, inhibitors that directly target immune-suppressive mechanisms of T cells have found clinical application withgreat success. The clinical application of these so called “check-point inhibitors”, however, is accompanied by severe sideeffects in treated patients. Thus improvement of the efficacy of current immune-therapeutic treatments is a major unmetneed. This proposal will employ the newest developments in antibody design to target the next generation of biologics righttowards tumour-residential Tregs or directly into the tumour micro-environment itself. In this way we will be able tospecifically shift the local immune suppressive environment within tumours, while leaving tissue homeostasis in noncanceroustissues unaffected, and thus diminish treatment associated side-effects.The here proposed project combines the expertise of fundamental immunologist, tumour immunologists and cell biologistswith that of a life-science biotechnology company and that of experts in clinical cancer research to address this aspect. Thisgroup will lead a training network that aims at educating a new generation of researchers, who will be able to bridge theinnovation gap between, on the one hand, early discoveries in tumour-immunology as well as in antibody technology and, onthe other hand, the efficient translation and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'eHealth Standards and Profiles in Action for Europe and Beyond' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The eStandards CSA is proposed by HL7, CEN TC251, & IHE, leading Standards Organizations (SDOs), and is supported by the eHealth Network, ISO TC215, GS1, IHTSDO, IEEE11073, and IMIA to advance eHealth interoperability and global alignment of standards with seven objectives: 1. Join up with Stakeholders in Europe and globally to build consensus on eHealth standards, accelerate knowledge-sharing, and promote wide adoption of standards.2. Deliver an evidence-based Roadmap for alignment, iterative consolidation, and broad acceptance of eStandards that is endorsed by SDOs, the eHealth Network, the providers, and the Industry.3. Contribute to the eHealth Interoperability Framework use cases focusing on clinical content modelling for different paradigms and embed a Quality Management System for interoperability testing & certification of eHealth systems.4. Collect evidence and provide guidance on the coexistence of competing or overlapping standards in large-scale eHealth deployment nationally and cross-border.5. Participate in EU/US MoU roadmap actions as the international patient summaries standard.6. Explore socio-economic aspects of eHealth interoperability, revisiting the language for user-vendor interaction that embodies ‘co-making’ in trust, collaboration and long-term engagement.7. Align across PHC-34 to nurture innovation, sustainability & growth under CEF and beyond contributing to Key actions of the Digital Agenda 2020. The proposal’s ambition is to strengthen Europe’s voice and impact, while reinforcing the bridges established with the EU Patient Summary guideline across the Atlantic in Trillium Bridge and among MS with epSOS, eSENS, Antilope, and EXPAND. The eStandards Roadmap and associated evidence base, a white paper on the need for formal standards, and two gu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Collective Syntheses and Biological Evaluation of Akuammiline Indole Alkaloids' (STRICTSYN), addressing dissemination and exploitation.

assistant: **Impact**

Natural product chemistry plays a pivotal role in drug discovery. A recent authoritative survey indicated that 61% of marketed drugs in the period of 1981-2002 could be traced to or were inspired by natural products. Since the composition and content of natural products vary from multi-factors, total synthesis has been considered as one of the most important components in the exploration of natural products. The proposal aims at addressing the collective syntheses of a series of bioactive indole alkaloids (strictamine, aspidophylline A and alsmaphorazine C) from a common intermediate. Moreover, bioactivities of these natural products as well as advanced intermediates and analogues will be evaluated by both high throughput screening and focused bioassays to explore their full potential. The target molecules have been reported to possess potent bioactivities, but their very low natural abundance hampered their detailed biological studies. Although considerable synthetic efforts have been made, no total synthesis of strictamine and alsmaphorazine C has been achieved due to their complex molecular architectures. The proposal presents novel and concise synthetic strategies featuring an earlier-stage quaternary carbon formation and a late-stage indole synthesis blueprint. Furthermore, the synthesis could be performed in both protective group-free and asymmetric versions, which perfectly matches the growing demand for economy of synthesis and drug discovery. Since the project is multidisciplinary merging organic chemistry, medicinal chemistry and biology, it will certainly represent a high-quality contribution to the research fields in Europe and may constitute the basis for the discovery of a new generation of potent lead compounds for drug discovery. At the same time, it off