RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Location Based Suggestion of Keyword Queries'.

assistant: **Objectives**

Query suggestion is a recent and important add-on feature of Web search engines (e.g., Google), which helps users to express their information needs precisely. Specifically, given the fact that the user may not be able to find appropriate keywords for her search, the system recommends to her a small set of keyword queries that are likely to match her original intention. As an example, when a user searches for “convertible car,” she may miss all the documents indexed under “cabriolet.” Therefore, the engine suggests “cabriolet” as a follow-up query to the user.  There has been extensive research in the past decade on effective query suggestion. However, none of the existing keyword query suggestion methods consider the user’s location. We argue that the queries suggested to a user not only should be semantically relevant to her original query, but also should give results near the user’s location, especially when these queries are expressed by a mobile user; otherwise, the suggested queries might not be of interest to the user. Therefore, there is a need for effective location-based keyword query suggestion (LBKQS) models. The objectives of this project are (1) the development of LBKQS models, (2) the evaluation of the proposed models, (3) the development of efficient and scalable LBKQS techniques based on the most effective models. In the end, we expect our system to provide appropriate query suggestions to mobile users in real-time.The subject of this project is timely and of great interest to the research community and IT industries, therefore the research publications that will arise from it will improve the visibility of European research internationally. The Experienced Researcher (ER) has a notable publications record and extensive experience in subjects related t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High - definition video extentiometer' under Fourth Framework.

assistant: **Concept**

Strain measurement is still performed mainly by contact sensing techniques with well known disadvantages. Existing non-contact strain measurement systems are nor yet sufficiently advanced for wide industrial application, e.g. : PC-based image processing with normal video cameras as well as laser scanners have insufficient optical resolution, Speckle interferometry is very expensive. The objective of this project is therefore to develop a medium priced strain measurement system based on advanced video technology, new optical colour sensors with high resolution and a DSP system for real-time image processing. Systems parameters shall be a measuring range of 1 -100 cm, a measuring frequency of > 0,5 kHz and a resolution of better than 1/40.000 of the measuring range. The strain measuring system is foreseen as OEM equipment for electric and hydraulic material test machines for stress, strain, fracture and shear measurement, especially for high strain and destructive testing. Compared to existing techniques, non-contact and highly automated measuring can be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Maximum energy yield from organic wastes and decontamination to a high quality organic fertilizer by a microbiological hybrid process (ENERDEC)' (ENERDEC) under Fifth Framework.

assistant: **Objectives**

Objectives and problems to be solved:Based on an existing organic waste treatment hybrid process B.S.F.C., in which the waste is separated in a liquid fraction for anaerobic digestion and a solid fraction for composting, the project objective is to establish an environmentally beneficial process with optimised utilisation of all output mass flows in terms of maximum energy yield and valuable soil fertiliser by performing the following measures:- improving energy production for different new organic waste materials;- upgrading of the biogas for use in the natural gas grid and in future in fuel cells;- depletion of heavy metals and salt in raw material to improve compost quality;- development of an economically acceptable method to reduce N and P contamination in the liquid digested residues for recycling into the process and environmental protection.Description of Work:- For maximum biogas output and cost effectiveness applicability tests of CSTR (continuous stirred tank reactor) and FBR (fluidised bed reactor) for digestion of the liquid fraction will be performed with new waste substrates from the leather industry and slaughterhouse at mesophilic and thermophilic conditions.- For the upgrading of biogas a small scaled prototype will be constructed and operated at the SME proposer MFN. To fulfil a cost effective cleaning system biological/chemical and physical methods will be combined. Therefore the prototype will consists of a bio trickling filter for removal of H2S, an activated carbon filter for removal of AOX and hydrocarbons, and an gas membrane filter for removal of CO2.- Variation of separation techniques and parameters in laboratory and technical scale at the waste treatment plant of the SME proposer SESA are necessary to find the key parameters for depletion of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a Direct Laser Joining of hybrid Plastic-Metal components for industrial applications' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Automotive industry is looking for reducing energy consumption by using lightweight structures instead of some metal parts. This fact is causing the introduction of plastic sections. But, as metals cannot be excluded as fundamental material in many applications; many products are made of multi-components where several types of materials are introduced. Up to date, the stable joining of plastics and metals is not easy and takes place by methods as adhesive bonding or mechanical joining, that involve a large number of production steps.The present project aims to overcome their disadvantages trough the development of a new innovative joining concept for Plastic and Metal materials using a direct non-contact laser joining process without extra filler, adhesive bonds or mechanical union but that offers a robust physical and mechanical bonding and ensures the integrity of the structure. The PM laser joint herein presented is led to offer higher process flexibility compared to mechanical joints especially through the use of flexible beam guiding systems. Compared to adhesive bonding solutions it can be much faster with high joint resistance and same flexibility but without contaminant risks. In addition, the shortening of the process chain will lead to a more economical and faster production.Another important aim of this project fits with a general requirement for technical components which is to achieve flexible automatic joining prototypes for dissimilar plastic-metal materials with short cycle times and a broad field of applications.The consortium counts with three large companies like FAURECIA, PSA and VALEO as end users mainly dedicated to automotive sector, LASEA as SME laser source integrator and ANDALTEC as high-tech SME supporting innovation in the plastic field. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GREENECONET: A best practice platform to support the transition towards a green economy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The unsustainable path of our current economic system in managing both natural and man-made resources demands a paradigm shift in our idea of economic development. We need to define an innovative, multidisciplinary and integrate approach to identify, develop and deploy technologies, tools and services promoting a transition to a low-carbon, sustainable, resilient and socially comprehensive economic development. This new economic paradigm has been called “the green economy”. The contribution of private enterprises and business communities toward the transition to a green economy has often been underestimated. Yet, Small and Medium sized Enterprises (SMEs) and corporate actors work as key players and they have the power to change the socio-economic and physical landscape. Many SMEs and corporate actors have introduced innovative solutions which have greatly contributed to our understanding of “green economy”, and have developed revolutionary organisational, behavioural and technological approaches to the problem of sustainability and human well-being. Despite these developments, a large part of the business communities lag behind the “best in class”. The aim of our project is to address two problems: 1) the disconnection between best in class / benchmark “green business” practices and the wider business communities 2) the disconnection between applied research institutions investigating models for a transition to a “green economy” and the business community. We will do so through the design, deployment and use of a suite of instruments and a series of activities, i.e. a “platform”, aimed at developing an exchange network of best practices involving the “best in class” private enterprises, the academic research institutions, business networks and the wider business communi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'TEMPORAL AND SPATIAL MODULATION OF ANTIVIRAL MAVS SIGNALING' (VIROPERO) under Seventh Framework.

assistant: **Objectives**

Viruses are of great importance for global public health. The first line of cellular defenses against viral infection begins with the binding of viral RNA to intracellular pathogen recognition receptors. Such interaction triggers the conformational change of these receptors and allows subsequent interaction with the adaptor molecule MAVS. Once activated, MAVS recruits a signaling complex able to activate transcription factors that induce the direct expression of ‘early IFN stimulated genes’ (ISGs), which have direct anti-viral effect.Until recently, the key adaptor molecule MAVS, was thought to localize exclusively at the mitochondrial membrane, therefore establishing mitochondria as a unique platform for antiviral signaling. Recent work has revealed that MAVS is also found on peroxisomes, organelles that are best known for lipids oxidation. Interestingly, peroxisomal MAVS induces a direct, rapid and transient, IFN-independent expression of ISGs, whereas mitochondrial MAVS induces both IFN and ISGs with delayed kinetics. Therefore, MAVS localization determines the type of signaling pathway activated during viral infection. The set of genes that are induced by peroxisomal MAVS and mitochondrial MAVS differ, suggesting that signaling from both organelles may be coordinated to ensure maximal antiviral gene expression.We propose to characterize the molecular basis for the regulation and coordination between peroxisomal and mitochondrial MAVS signaling in the context of infection by a variety of medically important viruses. The overall goal of this project is to understand innate immunity mechanisms that are taking places very early after virus infection. A better understanding of this arm of the innate immune response should shed some light on important mechanisms such as t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'OrganoCATAlytic approaches towards easily synthesized, economical, and high yielding oseltamivir derivatives' under Seventh Framework.

assistant: **Concept**

Despite widespread immunization, influenza still kills thousand of people, and costs to US, Europe and Asia enormous amount of money in term of healthcare expenses and productivity losses. While immunization remains an important approach to prevent influenza, small-molecule antiviral agents represent a novel opportunity for effective prevention and therapy of flu.  Inhibitors of neuraminidase, essential enzyme for viral replication in all three classes of influenza viruses, has been recently found. Two of these inhibitors have reached the market, namely, zanamivir (GSKBs Relenza (1) in July 1999, and oseltamivir phosphate (Gilead Bs Tamiflu (2), also marketed by Roche) in October 1999.  The recent healthy problem related to avian flu, has increase the public demand for stockpiles of Tamiflu, both as a reasonable frontline therapy against a possible flu pandemic and as a preventive agent. However, natural sources of drug (Shikimic acid) are scarcely, and increasing demand for oseltamivir phosphate has placed further pressure on Roche and the chemical community in general to develop new routes to the drug that do not involve complex natural products. In addition, the described synthesis are expensive and difficult. Moreover, in this synthesis use of hazardous azide-based reagents was necessary.  New routes to Tamiflu have been recently described, but more than 12 steps in one case and 17 in another are needed. In order to find new drug candidates, cut the drug costs and improving availability as well as efficiency, new chemical synthesis are necessary. We propose a new domino reaction based on an organocatalytic approach to the synthesis of new Tamiflu derivatives. The chemistry involved in this project is easy to perform, and well adapt to industrial contest. Moreover, n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum Spin Dynamics in Cobalt-based Single Molecule Magnets/Single Ion Magnets' (SPIDYM), addressing dissemination and exploitation.

assistant: **Impact**

In the field of molecular magnetism, research is centered on developing molecule-based systems capable of storing magnetic information at much higher densities than current technologies allow. Single-molecule magnets (SMMs) are particularly promising due to their unique properties like large spin in its ground state, strong magnetic anisotropy and the slow relaxation of magnetization that can be tailored for targeted applications. Precise deposition of SMMs on surfaces allow for controlled interactions and the potential to manipulate individual molecules, unlocking their potential for nanotechnological applications. However, this area remains underexplored. SPIDYM will generate for the first time fundamental insights on the properties, magnetic anisotropy, spin dynamics and molecule-surface interactions for carefully selected cobalt-based SMMs deposited on relevant surfaces. This understanding is essential for the development of nanotechnological devices based on SMMs. These goals will be pursued by multidisciplinary advanced measurements approach, synergizing synchrotron based surface sensitive X-ray absorption spectroscopy(XAS), X-ray magnetic circular dichroism(XMCD), lab-based electron paramagnetic resonance(EPR), infrared spectroscopy(FIR) and magnetic characterization combined with theoretical modeling to exploit electronic and magnetic properties of surface-adsorbed SMMs for potential applications in nanoscale data storage and spintronic devices. SPIDYM exploits the synergy between the applicant's extensive expertise in synchrotron-based x-ray methods and the host's expertise with lab-based spectroscopic techniques, EPR. Therefore, the action provides a unique opportunity for the applicant to strongly expand her skills, and for the host to become acquainted with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Material Testing and Recommendations for Hydrogen Components under fatigue' (MATHRYCE), addressing dissemination and exploitation.

assistant: **Impact**

The deployment of a large hydrogen infrastructure with societal acceptance relies on the development of appropriate codes and standards to ensure safety. While hydrogen infrastructures are gradually being built all over the world, there exist no international standard to properly ensure fitness for service of pressure vessels subject to hydrogen enhanced fatigue. For example, high pressure compressors and pressure buffers in FCV refuelling stations experience cyclic loading due to pressure variation. The MATRHYCE project aims to develop and provide an easy to implement vessel design and service life assessment methodology based on lab-scale tests under hydrogen gas. This methodology will be based on selection and further development of the most appropriate, reliable and easy to handle lab-scale test under hydrogen pressure to quantify the hydrogen induced fatigue of a material. The results shall be transferable, allowing to design a component and to assess its lifetime without full scale tests. At least three types of lab-scale tests will be carried out and carefully analysed to address the fatigue of pressure vessel steels without and under hydrogen pressure. The proposed rationale will be finally validated by means of fatigue tests under hydrogen pressure on full scale components. The obtained results and conclusions will allow prioritized recommendations to support ongoing or new RCS initiatives at the international level. Indeed, this project will provide data and methodology necessary to improve European and International standards on high-pressure components exposed to hydrogen-enhanced fatigue. The project aims to support and speed up the build of a safe and harmonised Hydrogen supply network in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Genome Stability: Coordination of chromosome segregation with cell division' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Mitosis is an intricately coordinated set of events that ensures the accurate inheritance of genetic information from one cell generation to the next. The genome, packed into chromosomes, is distributed between two daughter cells during anaphase. After completion of anaphase cells divide, i.e. undergo cytokinesis.It is poorly understood what regulates the timing of cytokinesis such that it only happens after anaphase is complete. How eukaryotes, including human, inherit their nuclear genome is a fundamental question in biology. It also has direct clinical implications as chromosome missegregation is a leading cause for miscarriages and birth defects, and is tightly linked to malignant tumour progression. This project has broad relevance to both the understanding of a fundamental biological process as well as human disease.We want to address how anaphase is coordinated with cytokinesis using budding yeast as the model system. Recent advances in the Dr. Uhlmann's laboratory have shown that the protease separase" triggers sister chromatid separation at anaphase onset and at the same time activates a phosphatase called "Cdc14". The Cdc14 phosphatase in turn is a key molecule thought to initiate cytokinesis. This dual role of separase is therefore critical t o the coordination of anaphase with cytokinesis.Two principal questions arise from this finding that will be addressed in this proposal: - How does one protein, separase, at the same time fulfil two roles, separation of sister chromatids as well as activation of Cdc14 phosphatase?- Given that Cdc14 phosphatase is activated simultaneously with anaphase onset, how is down-regulation of Cdk activity regulated to ensure completion of chromosome segregation before cytokinesis?To address these questions will include identifica