RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Holomorphic Partial Differential Relations', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The aim is to develop an emerging field of complex analysis and geometry focused on holomorphic partial differential relations (HPDR). Such a relation of order r is given by a subset of the manifold of r-jets of holomorphic maps between a pair of complex manifolds, and the main question is when does a formal solution lead to an honest analytic solution. This complex analogue of Gromov’s h-principle is highly important but poorly understood. The project will focus on the following problems.(A) Oka theory concerns the existence and approximation of holomorphic maps from Stein manifolds to complex manifolds, corresponding to HPDRs of order zero. The central notion of Oka theory is Oka manifold; this is a complex manifold such that the h-principle holds for maps from any Stein manifold into it. Recently developed techniques give a promise of major new developments on Oka manifolds and their applications to a variety of problems in complex geometry.  (B) Open first order HPDRs. Oka-theoretic methods will be applied in problems concerning holomorphic immersions and locally biholomorphic maps. (C) First order HPDRs defined by analytic varieties in the jet bundle. Application of Oka-theoretic methods in holomorphic directed systems, with emphasis on complex contact manifolds and holomorphic Legendrian curves.(D) Applications of Oka theory to minimal surfaces. Development of hyperbolicity theory for minimal surfaces. The Calabi-Yau problem for minimal surfaces in general Riemannian manifolds. Study of superminimal surfaces in self-dual Einstein four-manifolds via the Penrose-Bryant correspondence.  These closely interrelated topics embrace major open problems in three fields, with diverse applications.


**Keywords:** Oka manifold, Stein manifold, complex contact manifold, minim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biofouling reduction in marine aquaculture' (BRIMA), addressing dissemination and exploitation.

assistant: **Impact**

BIOFOULING causes serious technical and financial problems for European marine aquaculture. Structural fouling causes increased loads, abrasion, clogging and enhanced drag. For cultured animals, fouling can overgrow them, compete for space/resources and reduce growth to uneconomic levels. Financial impacts can be enormous, ranging up to total loss of product.The project has two basic OBJECTIVES:A) To devise and test novel approaches to antifouling,B) To develop and disseminate approaches to fouling managementOBJECTIVE A is divided into categories:a) Biological methodsb) Physical Methodsc) Chemical methods.OBJECTIVE A will be attained by laboratory and field testing at sites throughout Europe.OBJECTIVE B is divided into categories:a) Data collectionb) Systematic explicit socio-economic researchc) Development of a decision-support toold) Dissemination.OBJECTIVE B will be attained by desk study/literature search and interaction with industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DNA and chromosomes: Physical and Biological Approaches' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The objective of this proposal is to organise a high level multidisciplinary Euro Summer School on DNA and chromosomes. It is now clear that a full understanding of the structure and functions of DNA and chromosomes requires a multidisciplinary approach. Computer scientists for instance contribute to the analysis of genomic sequences or help deciphering gene expression using DNA chip technology. Physicists perform single molecule experiments on DNA, chromatin fibres and chromosomes, exploring unknown physical parameters and providing a new understanding of enzymatic catalysis. There is a growing understanding among molecular biologists that biology will in the future benefit from the knowledge accumulated in physics and in physical chemistry. This multidisciplinary approach, which has led to important results in the past, is expected to have a growing impact in the next decade.Indeed, this field attracts an increasing number of researchers coming from various disciplines. As a result, there are strong training needs. The goal of the present school is precisely to participate in the training of young scientists willing to enter this exciting field. The goal of this high level scientific conference is to provide a comprehensive and state of the art set of lectures on the various approaches used to study DNA and chromosomes. It aims at facilitating the communication between researchers from various disciplines and at fostering the development of new collaborations. Extensive courses (2-4 hours) will be given by 20 invited lecturers chosen among the leading experts in their field. The course will be planned for a mixed audience (physicists, molecular biologists, etc...) at the advanced PhD student/post doctoral level. The long duration of the courses will allow the speakers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engineering anti-tumour biosynthetic pathways to generate novel anti-tumour drugs' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to generate novel hybrid molecules, potentially showing anti-tumour activity, by engineering several pathways involved in the biosynthesis of anti-tumour drugs by streptomycetes. The target drugs for engineering will be the angucyclines (urdamycins), the aureolic acid group (mithramycin, chromomycin and olivomycin), the anthracyclines group and elloramycin and tetracenomycin. Gene clusters (or specific genes) involved in the biosynthesis of these anti-tumour drugs will be isolated and sequenced to identify potential gene functions and they will be used for interspecific exchange experiments to create new hybrid gene constructions. Novel molecules synthesised by these clones will be identified, isolated and their structures elucidated. Mutants blocked at specific steps of the biosynthesis will be also generated by gene replacement techniques and the accumulated products isolated and structurally identified. These accumulated products will be used for directed biosynthesis of specific strains or mutants to generate new compounds. Gene clusters will be also introduced into a streptomycete strain able to synthesise fluoroacetate such that fluoroacetate may be used as starter unit to generate modified molecules. In addition, new molecules will be also generated by feeding specific strains with compounds derived from polyketide model systems. Potential cytostatic activity of the novel molecules will be assayed using different tumour cell lines. The experimental approach used in this proposal will be a co-ordinated, multi-disciplinary study using molecular biology, organic chemistry and cell cultures and will involve five university research groups and two small/medium sized enterprises. Achievements of the goal of the project will have important biot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Co-diversification and co-evolution of human populations and cereals in Africa' (CODEV).

assistant: **Innovation**

The Neolithic agricultural revolution is a key step in recent human evolution that dramatically shaped genetic diversity and adaptations of today populations. Plant domestication played a crucial role in its set-up. Yet the genetics of human migrations and plant domestication is addressed separately. CODEV explores the interaction between these processes in Africa, with an innovative multidisciplinary approach that jointly analyses human and plant genomic data, complemented by ethno-linguistic and environmental information. The largest genomic data-sets available to date of three mayor African cereals and human populations will be analyzed to identify congruent and idiosyncratic signatures of spatio-temporal evolutionary processes. CODEV will inform about whether cereal and human populations have undergone parallel or convergent evolution and co-adaptation.CODEV will yield novel evolutionary insights on the neutral and adaptive dynamics associated with the agricultural transition, a topic of great scientific and public interest. CODEV will also contribute to strengthening research on Africa and African biological resources, still poorly characterized. Determining the genetic bases of adaptation to agriculture is relevant to understand farming-related human diseases. The identification of adaptive genes in cereals informs crop improvement towards more sustainable and hazard-resilient varieties. Transfer of knowledge and capacity building activities will be addressed to European and African graduate students and researchers and outreach events will allow sharing CODEV findings with the civil society.This MSC action will increase the researcher competitiveness for career consolidation through new knowledge on human evolutionary genetics and species interaction analysis, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modulation of Basket cell microcircuits in cerebellar cortex paroxysmal ataxia disorders' (BaskAtax).

assistant: **Concept**

The episodic ataxias are a group of hereditary conditions with recurring paroxysms of cerebellar dysfunction. They are rare; however they share important similarities to other more prevalent paroxysmal disorders such as migraine and epilepsy. The prototypic cerebellar cortex paroxysmal disorder is Episodic ataxia 1 (EA1), which is linked to dominantly inherited missense mutations in the Kv1.1 potassium channel subunit. Work from an animal model harbouring a human EA1 mutation reveals altered synaptic function at basket cell terminals in the cerebellar cortex. However how EA1 mutations affect basket cell regulation of Purkinje cell firing is unclear, possibly due to unforeseen changes in a specialized inhibitory structure called the pinceau. Furthermore the mechanism whereby local synaptic deficits extend to global cerebellar cortex network dysfunction during attacks of incoordination is unknown. This MSC research action aims to understand these processes using a combination of cutting edge in vitro and in vivo techniques. Using advanced electrophysiology techniques, I will assay basket cell pinceau function in mouse models of EA1, then using multi-photon and conventional microscopy I will map local basket cell microcircuits. Finally building on in vitro experiments I will assay candidate small molecule therapies in vivo, both with electrophysiology and with behavioural test of cerebellar coordination. The project allows me to train in state-of-the-art in vitro and in vivo methods while drawing on my extensive background in neuropharmacology, biochemistry electrophysiology. This research action will also advance our understanding of paroxysmal neurological disorders and identify new therapeutic targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Interactions between prefrontal cortex and area V4 in attention'.

assistant: **Concept**

A visual scene is typically crowded containing many different objects which cannot all be processed simultaneously by our visual system. Attention is employed to select behaviorally relevant stimuli and facilitate further visual processing. Studies in humans and non human primates have implicated numerous brain areas in visual attention but how activity in each one of those influences activity in other areas of the network remains largely unknown. Current theories on visual attention suggest that prefrontal and parietal cortical brain areas are part of an attentional control system. Accordingly, it has been suggested that these areas provide “top-down” signals that modulate sensory processing in early visual areas in favor of attended objects and/or locations that require further analysis by our visual system. To test the hypothesis that the prefrontal cortex is a source of top-down signals to early visual areas we will conduct neurophysiological experiments in non human primates engaged in a behavioral task in which attention is guided on the basis of object features. We will carry out extracellular recordings in the prefrontal cortex and area V4 simultaneously in order to study how neurons across the two areas interact and how their interaction is modulated during attention. Moreover, to establish the anatomical and functional substrates that mediate attention in the prefrontal cortex and area V4 we will examine the contribution of distinct classes of neurons in attentional mechanisms. The proposed study is expected to enhance our understanding of the neural basis of selective attention and reveal more general principles of brain function. Understanding the neural basis of attentional mechanisms is critical in order to find better cures for attentional deficits that a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hybrid Optical Interferometry for Quantitative Cancer Cell Diagnosis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A major challenge in the field of optical imaging of live cells is to achieve label-free but still fully quantitative measurements, which afford high-resolution morphological and mechanical mapping at the single cell level. In particular, developing efficient, non-subjective, quantitative optical imaging technologies for cancer cell diagnosis is a challenging task. The ground-breaking goal of this research project is to establish a robust experimental toolbox for label-free optical diagnosis and monitoring of live cancer cells in-vitro and their potential of metastasis. Optical interferometry is able to provide a platform for imaging live cells quantitatively without the risk of effects caused by using external contrast agents. By overcoming critical technological barriers, I suggest novel hybrid optical interferometric approaches that provide a powerful nano-sensing tool for label-free quantitative measurement of cancer cells. This will be obtained by recording the dynamic quantitative, three-dimensional sub-nanometric structural and mechanical characterization of live cancer cells in different stages. For this aim, I will develop a novel low-noise broadband, common-path, off-axis interferometric system for sub-nanometric physical thickness and mechanical mapping of live cells in thousands of frames per second. Additionally, I will develop rapid tomographic approach for fully capturing the cell three-dimensional refractive-index distribution, as a tool to characterize cancer progression. Interferometry will be combined with multi-trap holographic optical tweezers and dielectrophoresis to enable complete cell manipulations including full rotation, imaging of non-adherent cells, and mechanical measurement validation. New set of interferometry-based quantitative parameter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Measuring health and disability in europe: supporting policy development' (MHADIE) under Sixth Framework.

assistant: **Objectives**

Disability is a multi-dimensional phenomenon arising out of an interaction between the individual's health status and the physical and social environment. Disability data, and the instruments to measure it, must reflect this bio-psychosocial model of disa bility. Valid and reliable information are essential to design, implement or evaluate policies and legislation to combat discrimination and promote social integration, participation and enhance opportunities. The World Health Organization's International C lassification of Functioning, Disability and Health(ICF) provides the framework for documenting the interaction between health status and environmental features,and the differential distribution of disability among different groups in different contexts. This Co-ordination action will demonstrate the feasibility and utility of the ICF model in the measurement of types and prevalence of impairments, therefore using already existing measurement instruments.It will give evidence that data currently being c ollected, nationally and internationally, embody conceptual confusions, inconsistencies and ambiguities about disability and the relationship between health conditions,impairments and environmental factors. The project objectives are: 1) to use the ICF model as the structure for analyzing existing general population health surveys and education statistics data 2) to show that the ICF model is adequate for describing and measuring patterns of disability in clinical samples of selected conditions in diff erent countries cross-sectionally and over time as well as feasible and useful inclinical and educational sectors 3) to produce policy recommendations and guidelines concerning how the existing sources of data can be harmonised with the ICF model.The meth odology used w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Role of bacterial cellulases in the transition from free living to root endophytes in rapeseed crops and in the design of efficient biofertilizers'.

assistant: **Concept**

One of the main challenges for humanity during next decades will be to increase food production while using scarce resources and protecting the environment, being therefore one of the priorities of the European Program “Horizon 2020”. Plant’s productivity can be enhanced by the activity of Plant Growth-Promoting (PGP) bacteria, applied in agricultural fields as biofertilizers or plant probiotics, constituting an environmental friendly manner to increase crop yields. Biofertilizers have been applied in agriculture during decades, but in many cases bacteria which showed great PGP potential in lab conditions, fail when applied in natural soils, probably because they are out-competed by the soil native microbial populations or they are unable to adapt to the new environmental conditions.Based on the model Rhizobium-clover, it is known that bacterial cellulases are crucial in the bacterial entrance into the root. Nevertheless, the implication of these enzymes in the active entrance of bacterial endophytes in non-legume crops has not been studied yet. This project aims to research, using a trascriptomic approach and endophytes mutant strains isolation, the role of cellulases in the capability of endophytes to enter non-legume plant roots, using rapeseed (B. napus) as model plant. If cellulase encoding genes enable active root infection, giving an advantage over passive mechanisms, selection of bacterial strains not only on the base of their PGP capacity, but also on their ability to enter the plant -where they have less competitors and are protected from abiotic stresses-, will allow the design of more efficient bacterial biofertilizers. The ultimate goal of this project is to lay the firm foundations for the development of biological microbial-based fertilizers which shall a