RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CEREBRAL ASYMMETRY: NEW DIRECTIONS IN CORRELATES AND ETIOLOGY' (CANDICE), addressing dissemination and exploitation.

assistant: **Impact**

150 years after Broca's seminal statement ""Nous parlons avec l'hémisphère gauche"" we still do not know how or why we have this bias. I propose that by studying cases of impaired language development and combining genetic and neuropsychological approaches we will be able to make a leap forward in our understanding of the quintessentially human characteristic of functional cerebral asymmetry. I argue that contradictory findings in the literature may be reconciled if we adopt a novel approach to cerebral asymmetry. In particular, I propose a network efficiency hypothesis which maintains that optimal development depends on organisation of key language functions within the same cerebral hemisphere.In project A, I will combine behavioural measures with functional transcranial Doppler ultrasound (fTCD) measures of blood flow and functional magnetic resonance imaging (fMRI) to identify individual differences in patterns of dissociation between language functions in lateralisation. In project B I will test the prediction that risk for language and literacy impairment is increased if different language functions are represented in opposite hemispheres. For project C, simulations of predictions from genetic models will be tested using data on twin-cotwin similarity in language lateralisation. Project D will test a 'double hit' genetic model that predicts that neurodevelopmental abnormalities, including language deficits and inconsistent asymmetry, arise when there is more than one hit on a functional brain circuit. For this study we will use an existing sample of individuals already known to have one 'hit' on the neuroligin-neurexin circuit, viz people with an additional dose of neuroligin caused by an extra sex chromosome. Project E will focus on individuals with inconsistent p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Secure, reliable machine learning based technology platform for the creation and authentication of Digital Identities to enable safe digital transactions across Europe'.

assistant: **Innovation**

Fraud due to Digital ID (Identity) thefts is a huge economical and security problem for organizations. As a token, in 2018 American companies lost $3.4 billion in new accounts fraud.  Furthermore, Digital ID fraud undermines digital engagement as users do not trust their Digital ID security.   A secured system of Digital ID Verification is mandatory to drive digital growth. However, while Digital users demand better security, they are frustrated by the current Digital ID verification methods.  43% of digital users think that Digital ID verification solutions are cumbersome and are saying NO to current procedures to verify their Digital ID. The challenge is to build a secure, fully automated and user-friendly Digital ID verification for customer on-boarding.   PXL Vision AG has developed a proven solution is Daego, a modular, user-centric, fully automated, scalable and secure software platform that best optimizes company resources and UX for customer on-boarding.  Based on unique technical features that go beyond state-of-the-art, the deployment of DAEGO has huge benefits for users:  100% reduction of fraud; >75% reduction in customers on-boarding cost; BIG increase in customer digital engagement; as little as one week for deployment; low implementation risks proven in leading industrial verticals.  The business opportunity is huge: the Digital ID Verification market size is expected to grow from $6.0 billion in 2019 to $ 12.8 billion by 2024, at a CAGR of 16.0%.  Market drivers are the rising number of identity frauds, stronger regulations on general data protection, enterprise mobility and BYOD (bring-your-on- device) trend. Created for entrepreneurs with strong technical and business experience, PXL Vision has become in two years in the market, a reference for Digital
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PepZoSkin: Biocompatible Self-powered Electronic Skin' (PepZoSkin), addressing dissemination and exploitation.

assistant: **Impact**

Electronic skin is seen as the next generation of wearable technology, ideally made of thin, self-powered, self-healing and flexible electronics able to mimic or augment natural skin functionalities.Smart prostheses to give amputees the sense of touch, completely biocompatible skin patches for wound care, or new on-skin drug delivery systems are only few e-skin applications that are being explored by the research community for the last several years.The main problems hindering the e-skin revolution are the lack of fully biocompatible piezoelectric materials, which are the basic component of any e-skin system, and the unavailability of adequate energy harvesting technology, which allows realizing an extremely compact and energy autonomous device.In the PepZoSkin project, we propose to develop an ultra-thin, flexible, self-powered e-skin device that combines innovative piezoelectric materials, microelectronics and sensors for wearable and implantable applications.In the frame of the main ERC Grant, we have synthesized radically new peptide-based materials with exceptional piezoelectric performance, unprecedented mechanical properties, and inherent biocompatibility, and used these materials as an active layer in basic sensing devices.  In this PoC project, based on these promising results, we will further develop these basic devices to a TRL5 self-powered biocompatible core technology for an e-skin device. Our vision is to turn our core material into a key component of next generation compact and self-powered wearable and implantable systems, targeting biomedical applications as a market entry point. The e-skin market is expected to be worth more than 15 B$ by 2028. During this PoC project, together with medical, business and industrial stakeholders, we will focus on the v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CLINICAL ONCOLOGY NETWORK FOR QUALITY IN EUROPEAN STANDARDS OF TREATMENT' (CONQUEST).

assistant: **Innovation**

CONQUEST seeks to cut out big variations in recurrence and survival rates for patients after cancer treatment (within and between EU countries). It will develop a quality management system with telematics and advanced multimedia work stations to provide specialists (of multiple disciplines) with a refined diagnosis and treatment tool to guide them through the latest protocols, while automatically supporting and checking patient treatment data and integrated imaging techniques. Better cancer treatment will result in reduced recurrences and treatment complications, leading to cheaper health care. The application is planned for future adaptation to other forms of medical care. CONQUEST participates in the project cluster entitled: ACTION for Telematics Applications for Cooperative work of Healthcare Professionals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A highly scalable grid-scale energy storage system utilising 3rd generation flywheel technology for effective integration of renewable energy.' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Electrical energy storage (EES) is a fundamental enabler to the deployment of renewable energy and provides cost-savings in other markets. The market is projected to grow from 1.1 GW in 2016 to 21.6 GW in 2025. Pumped hydroelectric storage (PHS) accounts for 98% of global energy storage, however they are geographically limited, environmentally impactful and require huge upfront costs. Other state-of-the-art solutions available in the market i.e. batteries for EES cannot scale-up to meet the demands on the electrical grids and networks. This results in an underutilisation or ineffective use of renewable energy sources. Teraloop has created a highly scalable, kinetic energy storage system, which draws upon proven technologies (flywheel energy storage, magnetic levitation and brushless motors.), innovatively configured for grid-scale storage with minimal visual and environmental footprint. The scalability of the product results in applicability from voltage support to load following. The development roadmap comprises three major phases: Phase1: Market & technical feasibility: Utilise SME instrument phase 1 funding to complete market analysis – define requirements and favourable market conditions. Find a demonstrator partner and explore engineering requirements. Phase2: An industrial demonstrator of 10MW Teraloop: Utilise SME instrument phase2 funding to find suitable stakeholders and subcontractors. Build, run and test Teraloop. Expand IP, communicate and disseminate phase 2 activities. Phase3: Commercialise 10MW Teraloop and develop 100MW Teraloop: Teraloop recognises their ambitious vision and mission will only be delivered through strategic partnerships with investors, technology companies, the energy storage industry and the public sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Physics Prospects at ALICEat LHC' (EXP-HEP) targeting Sixth Framework.

assistant: **Abstract**

The ALICE experiment is a highly complex project involving about 1000 physicists from around the world. Both India and the United Kingdom are involved in it. The main aim of the project is to study the properties of the Quark-Gluon Plasma (QGP), a new form of matter which exists at extremely high energy densities. In ALICE, this will be achieved by colliding lead ions together in order to form tiny fireballs with temperatures of up to one million times that of the centre of the Sun.The main purpose of my work at Birmingham would be dedicated to physics analysis, where simulations can already be used in preparation for real data. I aim to take a major role in the physics analysis programme currently underway at Birmingham, which is studying the production of short-lived resonances. The lifetimes of these particles are similar to that of the fireball itself, and their properties tell us much about the properties of the fireball and the QGP. It may also be possible to use them as an indicator for whether a second phase transition involving a phenomenon called chiral symmetry restoration" has taken place.Birmingham is also responsible for the design and construction of the Central Trigger Processor (CTP). I would also aim to be involved in this project, in two ways. On a practical level I am interested in the design of a web-based graphical interface allowing control of the CTP. In addition, I am interested in studying the tuning of the trigger to optimise trigger rates for data taking. Many processes can be measured, and their contribution to the overall data rate must be tuned by scaling factors to achieve the most efficient physics analysis. I am interested in this project as I wrote the original trigger simulation program some six years ago."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cracking the Code for Protein Quality Control Mechanisms Recognizing Exposed Hydrophobicity in Protein Substrates' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Proteostasis is a highly regulated process by which cells maintain a healthy proteome. Loss of proteostasis is a common feature of aging and disease. To preserve proteostasis, the cell has developed protein quality control (PQC) pathways that monitor a proteins’s fate from synthesis to degradation. Exposed hydrophobic residues in aberrant or mislocalized protein substrates is a key feature recognized by distinct PQC mechanisms. If not handled properly, exposed hydrophobicity can result in protein aggregation and subsequent reduced cell fitness. To prevent accumulation of toxic aggregates, cells are equipped both with chaperones and proteolytic pathways. Within the degradation systems, E3 ligases are the major determinants of specificity, which is achieved through their selective recognition of specific short peptide motifs, or degrons, in substrate proteins. Despite the growing list of PQC players and substrates, it has yet to be determined what are the client range, selectivity and specificity of each of the PQC mechanisms. The objective of this proposal is to systematically investigate the exposed hydrophobicity “code” and to advance the state-of-the-art of the PQC field. Here, we utilize the GPS-peptidome method that we recently developed together with genetics, biochemistry, cell biology and proteomic approaches to: (1) map distinct classes of hydrophobic degrons to elucidate the specificity of substrate selection; (2) identify novel E3 ligases playing a role in PQC pathways, explore redundancies among them and identify endogenous substrates proteome- wide; (3) investigate the physiological significance of PQC mechanisms. This work will provide a comprehensive view of PQC pathways that recognize hydrophobicity. This is critical to further our understanding on how ab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Incubate a New Learning and Inspiration Framework for Education'.

assistant: **Objectives**

INLIFE will provide an innovative gamification framework targeting both typical as well as special education and social inclusion activities based on Serious Games. INLIFE’s core concept leverages on the potential of the Internet-of-Things (IoT) paradigm to directly link actions, decisions and events happening in real-life with in-game educational progress and modern gaming technologies. This bridge strengthens the infusion of gamification into non-leisure contexts, boosting at the same time the creation of new educational methodologies as well as new business opportunities. The challenge INLIFE addresses is to effectively join the forces of gaming industries, IoT technologies and social science research outcomes to support the development of creative and effective applications in education and for social inclusion.The INLIFE framework will be based on an open, layered architecture, consisting of modules supporting agile abstraction methods, model-driven development and transformation technologies, as well as state-of-the-art gaming and human-computer interaction techniques. It will enable the bidirectional, real time communication between the serious game and the surrounding environment, bringing the player in the center of the game while living the reality.The INLIFE technologies, tools and software solutions will be validated in four carefully set pilots through the integration and demonstration of two selected serious games, one for the education of children and students on environmental sustainability and one targeted at assisting children with autism to learn, thus facilitating their social inclusion. The realization of the INLIFE vision will ultimately pave the way for the proliferation of new innovative IoT-based serious games, created also by third parties, fea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Plasma Reactors for Efficient Fertilizer Production Applied in a Real Environment' to be submitted under Horizon Europe.

assistant: **Abstract**

My project aims to demonstrate the proof of concept of new plasma reactors for sustainable and energy-efficient NOx production from air, as basis for green fertilizer production. Plasma is created by applying electricity, it is quickly switched on/off and has no economy of scale, so it is ideal in combination with renewable (intermittent) electricity, and thus, of interest for electrification of fertilizer production. This project originates from my ERC SyG, where we obtained record values in plasma-based NOx production and energy cost (EC). Now it is time to bring this into real application through optimization of the reactor design and its performance.We will build three different plasma reactor designs, based on innovative computer model predictions, and test the optimal matching to the power supply for maximum efficiency. We will also test the effect of quenching, heat recovery, pre-heating, gas recirculation and sorption materials, to further improve the performance in terms of NOx yields and EC. Subsequently, we will test the reactors in real world context, i.e., air with varying humidity and exploring the reactor robustness for both continuous long-term and intermittent operation. In the last two months, we plan demos for interested stakeholders, serving as real-life market analysis. Finally, we will perform a SWOT analysis, comparing the three reactors in terms of overall performance in real world context, to decide which reactor will be selected for up-scaling and potential commercialization. PREPARE aims to drive innovation for the application of HNO3 and NH4NO3 production, that is now mainly relying on non-sustainable resources. In addition, it can provide a solution to curb NH3 emissions from livestock and poultry farming, by letting the plasma-produced NOx
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Identification of the gene for Peutz-Jeghers syndrome, a hereditary disorder predisposing to bening and malignant tumors of multiple organ systems' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Objectives:?To identify the gene predisposing to Peutz-Jeghers syndrome through positionalcandidate and positional cloning strategies.?To study the role of the identified gene in sporadic and hereditary tumorigenesis.Brief description:The gene predisposing to Peutz-Jeghers syndrome (PJS) has recently been localized to chromosome l9p by the participants. The ultimate objective of this work is to identify the gene predisposing to PJS, and to determine the role of the identified gene in sporadic tumorigenesis. The importance of this goal is related to two aspects: 1) For PJS families the identification of the gene gives the opportunity to undertake predictive genetic testing. This is of benefit, because presently asymptomatic at risk individuals are recommended to undergo clinical screening procedures aimed at early tumor detection (though the screening is far less extensive than, for example, in hereditary nonpolyposis colorectal cancer kindreds). Genetic testing should be offered to the families only after appropriate genetic counseling, and at first in a research environment. The long-term objective is to understand the pathogenetic mechanisms underlying the syndrome, in order to be able to prevent tumor formation in the affected individuals. 2) For cancer research in general, the goal is to identify a novel tumor suppressor gene, which is likely to have relevance in the tumorigenesis of multiple organ systems. As the cancer spectrum in PJS seems to include at least gastrointestinal, breast, ovarian and testicular malignancies, it is possible that sporadic forms of these tumors arise in part from the background of somatic PJS gene mutations. The previous examples of e.g. familial adenomatous polyposis, Li-Fraumeni -syndrome and hereditary retinoblastoma have shown that