RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Flow Control for Industrial Design'.

assistant: **Innovation**

Aviation contributes to more than 2% of global greenhouse gas (GHG) emissions, in the absence of further measures, carbon dioxide (CO2) emissions from international aviation are estimated to almost quadruple by 2050 compared to 2010. Efforts to reduce GHG through the development of alternatives to traditional fossil-fuelled thermal engines have made great strides. Yet large capacity, long-range electric vehicles with operating speeds similar to or faster than current commercial vehicles are not expected to become feasible for several decades due to the limitations of battery energy density and cost. An alternative short-term solution that is being investigated in Purdue University by Prof. Paniagua with intense interest worldwide is to utilize a rotating deto-nation engines (RDE) to improve the efficiency and reduce the size/weight of current thermal gas turbines. If utilized with hydrogen, with high energy-to-mass ratio and robust detonation properties, RDE will provide the best chance to realize long-range, high-payload flight with zero greenhouse gas emissions . However, the development and performance of a high-efficiency RDE is inhibited by two main fluid dynamic problems: the flow separation caused by high pressure gradients, and the unstarting phenomena across the internal turbine pas-sages. The numerical solution, analytical analysis and control  of those problems is the main objective of FLOWCID.FLOWCID proposes a 24-month long outgoing phase (and 12 months return phase) of Prof. Eusebio Valero (the Researcher) from Universidad Politécnica de Madrid UPM (the Beneficiary), to Zucrow Labs, at Purdue University, USA (the Host) under the supervision of Prof. Guillermo Paniagua (the Supervisor).


**Keywords:** numerical simulation, flow control, optimization, aeros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of novel Non Destructive Testing (NDT) techniques and autonomous robots to be deployed by Remote Operating Vehicles for the sub-sea inspection of offshore structure welds - DEMOnstration', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The SubCTest Demo project, a continuation of the FP7 R4S SubCTest project,  has the objective to successfully demonstrate a robust NDT system, deployed by a Remote Operating Vehicle (ROV), that will reliably  detect and evaluate discontinuities in pipes, risers and tubular structural components, including the welds.Long range ultrasonic testing (LRUT) will be used to detect, locate and qualitatively assess the indications over distances of tens of metres either side the test site. Ultrasonic testing using electro-magnetic techniques will be used to evaluate, size and quantitatively assess discontinuities detected by LRUT.Validation of  the scanning and clamping manipulator systems will be demonstrated and analysis of the achieved accuracy will be conducted. Validation procedures will test both the reliability and robustness of the NDT system within prescribed underwater pipes or structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Activity-Dependent Maturation of Inhibitory Processing in the Spinal Dorsal Horn' in the context of a Seventh Framework call.

assistant: **Objectives**

In the early postnatal period neonates are particularly sensitive to touch, often responding with exaggerated reflexes and whole-body movements to an isolated cutaneous stimulus. This suggests a predominance of excitation over inhibition in spinal sensory networks, which may facilitate activity-dependent synaptic strengthening. We have recently shown that neonatal hypersensitivity to touch is due to the late maturation of glycinergic inhibitory signalling and that this signalling, in turn, requires nociceptive activity in the dorsal horn at a critical postnatal period. However, the phenotype of the interneurons involved and the mechanism for their maturation remains to be determined. Parvalbumin expressing neurons form a subgroup of inhibitory interneurons that express both GABA and glycine and are involved in the control of innocuous afferent input in the adult dorsal horn making them a key target for this process.  Our pilot data shows that parvalbumin is not expressed in the dorsal horn until the second postnatal week, coinciding with the behavioural decrease in touch-hypersensitivity. Using a combination of cutting edge targeted genetic manipulations and in vivo electrophysiological recordings of dorsal horn neurons, this project will identify which populations of interneurons inhibit tactile activity in the neonatal and adult dorsal horn and which primary afferent inputs drive their activity-dependent maturation. This data will provide fundamental biological knowledge required for better management of infants in intensive care.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stochastic electrochemistry for catalysis and analysis of carboneous bio-electrodes.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Bio-electrochemical sciences are essential for the development of biosensor and biofuels cells. The precise nano-structuration of conductive materials with electro-active enzymes allows the reversible transduction of electrical energy to chemical energy via direct electron transfer (DET). The operational stability of bio-electrocatalytic systems is limited by the constant and strong electrical field building-up at the interface. The electrode polarisation generates a strong and static electrical field rigidifying the interfacial electronic double layer, often preventing free enzymes’ dynamics and leading to an enzymes’ loss of activity due to the destruction of their active 3D structure. Customized electrical polarisation patterns have the potential to enhance both electro-enzyme stability and efficiency. Biological electronic transfers processes being non-linear, it is expected that electrical stochastic signal excitation can greatly influence the electron transfer process at a bio-electrode.This proposal focusses on gaining new knowledge about the electronic stochastic and unambiguous stimulation of bio-electrodes for catalytic and analytical purposes. The first objective is to synthesize nanostructured carbon nano-dots (C-dots) electrodes for the immobilisation of redox enzymes. C-dots possess a so-called trap-state; an energetic level that can be engineered to match biological redox cofactor potentials and thus enhance electronic coupling between the electrode and redox active enzymes. The second aim is to investigate pulsed and alternative current polarisation for enhancing bio-electrocatalysts efficiency and electro enzymes’ stability with non-ambiguous electrical waveform. The third aim of this proposal is to develop a novel electro-analytical technique relying o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evolution of neuroanatomical diversity: A phylogenetic comparative analysis across vertebrates using MRI.' (BrainTree) under Horizon 2020.

assistant: **Objectives**

The study of the evolution of the brain across species provides a unique perspective on the sources of normal and pathological variability in the human brain – a major challenge for neurosciences today.I propose a project to study the evolution of the vertebrate brain with unprecedented detail. I have a strong background in neuroimaging, computational neuroanatomy and the creation of platforms for real time collaboration in neuroimaging. During the last years I have worked on the analysis of the neuroanatomical development of the human brain and the evolution of primate brain folding, as well as in the development of Web tools to allow distributed collaboration among scientists. I propose to use this expertise to build the largest, open database of magnetic resonance imaging data of vertebrate brains. I will use state of the art computational neuroanatomy methods to build precise brain reconstructions and automatically extract a series of neuroanatomical measurements of regional brain volume, surface-based shape information and brain folding. In addition, I will develop new methods to capture the variability in shape and folding patterns using graph theory and deep learning algorithms. I will test different evolutionary scenarios using phylogenetic comparative methods, to estimate ancestral phenotypes, evolutionary changes, and the emergence of multivariate relationships across brain structures.My project will be developed in collaboration between the Group of Theoretical and Applied Neuroanatomy at Institut Pasteur, the National Natural History Museum in Paris and the Institute of Biology of the École Normal Supérieur. This collaboration will provide the ideal framework for my project, combining the availability of one of the world’s largest vertebrate brain collection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling and strategies for the assessment and OPtimisation of Energy USage aspects of rail innovation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of OPEUS is to develop a simulation methodology and accompanying modelling tool to evaluate, improve and optimise the energy consumption of rail systems with a particular focus on in-vehicle innovation. The OPEUS concept is based on the need to understand and measure the energy being used by each of the relevant components of the rail system and in particular the vehicle. This includes the energy losses in the traction chain, the use of technologies to reduce these and to optimise energy consumption (e.g. ESSs). Specifically, the OPEUS approach has three components at its core: i) the energy simulation model ii) the energy use requirements (e.g. duty cycles) and iii) the energy usage outlook and optimisation strategies recommendation. The concept builds on an extensive range of knowledge and outcomes generated by a number of key collaborative projects (e.g. CleanER-D, MERLIN, OSIRIS, RailEnergy, ROLL2RAIL) underpinning the research proposed, ALL of which have been led by OPEUS consortium members. Particularly the tool developed for the CleanER-D project will be used as starting point. Significant complementary work from the academic community will also be used to enhance the activities of the project. Specifically, these previous projects input will be used to:• Expand and develop the simulation tool (CleanER-D, MERLIN);• Complete the operational requirements by enhancing the urban duty cycles (OSiRIS);• Provide a global vision of energy consumption in railways (CleanER-D, OSIRIS, RailEnergy)OPEUS’ ambition is to firmly contribute to the following key areas:• Understand energy consumption of urban railways;• Develop a tool to objectively compare technologies and strategies aimed at optimising the energy usage of railway systems;• Unlock the potential contributio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BIOLOGICAL CONTROL OF AIR-BORNE NECTROTROPHIC PLANT PATHOGENS BY SUPPRESSION OF SPORE PRODUCTION' (BIOSPORSUPPRESS).

assistant: **Concept**

AIM: Support of implementation of the reformed CAP with respect to the reduction of environmentally harmful plant protection products by developing economically sound production methods compatible with the requirements of protection of the environment.OBJECTIVE: Minimizing the use of and dependence on chemicals in the control of plant diseases of leaves, stems and fruits.STATE OF THE ART: The natural phenomenon of competition between saprophytic and necrotrophic pathogenic fungi in dead plant material will' be exploited in order to suppress the dissemination (sporulation) of the pathogen. The common saprophytic fungus Ulocladium atrum competes successfully in dead plant material with Botrytis cinerea and other fungi.Preliminary experiments demonstrated the validity of this approach to control diseases caused by polycyclic air-borne plant pathogens sporulating on dead plant tissue such as B. cinerea (grey mould), a major global pathogen on grapevine, strawberries, tomatoes, cucumber, protein crops and ornamentals. In the EU, in grapevine alone, annual costs of fungicides for control are c. 150 million ECU. Fungicide-resistance threathens economic crop production and accumulates the use of chemicals.Breeding for host-resistance against B. cinerea is not likely to be successful. In order to demonstrate its non-specificity, the proposed Ibiocontrol method will also be tested against Septorioses, causing serious damage in wheat and vegetables.RESULTS: A multidisciplinary research effort of universities, research stations and industry will result in a novel non-specific biological method of sporulation suppression ready for commercialization that can be applied against Botrytis, Septorioses and other necrotrophic pathogens in integrated as well as organic farming systems.I MA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Nanomedicine based approaches for the treatement and diagnsotic of different Lung diseases'.

assistant: **Objectives**

Nanotechnology concepts have integrated into almost all aspects of current research and the present research area is recognised to be one of nanoscience. Nanomaterials are promising materials to develop new technologies in every branch of science and technology. This is also true when it comes to the biomedical field, where nanotechnology in the form of nanomedicine has a  great potential to overcome some of the current limitations using conventional analytical and therapeutic approaches. The focal point of  the LungCare project  is to turn nanotechnological potentials into tangible outcomes with benefits for patients and the society at large. The philosophy behind  LungCare is to provide improvement to the treatment of Pseudomonas aeruginosa (PA) infections via nanovaccines and inhalable therapeutics. It focuses also on the pending question for early and accurate diagnostics  of tuberculosis (TB) and  lung cancer via the development of  sensitive point of care testing devices. In case of lung cancer, sensor development will be accompanied by quantitative image analysis to increase diagnostic accuracy and improve our understanding of the disease characteristics. The LungCare project aims at training of the next generation of students in this rapidly advancing field at the interface between chemistry-physics-biology-medicine and to up-date and improve the know-how of senior researchers and PIs in important parts of nanomedicine such as clinical assay development, state-of the art of organoid developments to limit  in vivo testing via and the implementation of artificial intelligent in diagnostics. The different intersectoral secondments  to 2 European countries (France, Austria), 2 associated countries (Turkey, Ukraine) and one associated partner (Argentina) will strengt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Values, Equality and Differences in Liberal Democracies. Debates about Female Muslim Headscarves in Europe.' (VEIL), addressing dissemination and exploitation.

assistant: **Impact**

The VEIL Project focuses on the debates, conflicts and regulations concerning head- and body coverings of Muslim women in the public sphere, particularly in public institutions such as schools, universities and the courts. As a highly visible symbol of religious difference and conflicting values the Muslim headscarf has been the subject of heated debates across Europe and subjected to legal regulations in some European countries.One of our assumptions is that in debates about the headscarf fundamental values and norms of liberal democracies are not only re-negotiated but also collective identities re-constructed within the European integration process. Moreover, the issue reveals the gendered nature of values and norms that widely prevail in liberal democracies in Europe. VEIL compares policy and media debates in eight European countries and the European Union. The aims of the project are: first, to map out and compare the fundamental values and political principles of the main actors in the headscarf debates and second, to explain the differences and similarities in the conflicting values as expressed in the policies on Muslim headscarves.The project suggests a gender-critical frame analysis of policy documents (e.g. court verdicts, laws, parliamentary debates, media articles) using a comparative perspective for encoding values and norms. The project will also incorporate a comparative analysis, which focuses on citizenship regimes and immigration policies, on gender regimes and the relationship between the state and religious communities or institutions. The innovative potential of this interdisciplinary study of religious and cultural value systems consists in its policy-oriented social science approach and its gender-sensitive analysis of identity-building processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advancing genetic medicines for inherited kidney disease' (RENALGENE).

assistant: **Concept**

Chronic kidney disease (CKD) is a leading cause of global mortality, affecting ~13% of global population. Inherited kidney diseases (IKD) are estimated to account for a 30% of CKD cases. Despite the unprecedented development of genetic medicines in the past decades, to date no kidney gene therapy intervention is available. Renal gene therapies have encountered two main barriers: (1) its complex anatomy and function has hampered efficient and specific delivery of genetic therapies to the kidney, and (2) many IKDs are caused by mutations in large genes, and therefore, traditional gene supplementation strategies using efficient and safe in vivo vectors (such as adeno-associated viral vectors or AAV) cannot be developed due to the limited packaging capacity. The main goal of this proposal is to create solutions for these challenges by developing novel gene therapy vectors with improved kidney targeting and genome editing strategies to correct the genetic defect in large genes that cause IKDs.Recent advances in the field of discovery and engineering of gene delivery vehicles combined with CRISPR-based gene editing technologies have opened the avenue towards developing efficient and safe gene editing therapies. In this proposal, we will develop in vivo genome editing approaches for Autosomal Dominant Polycystic Kidney Disease (ADPKD), the most frequent IKD with an incidence of 1:1,000. For this, we will develop novel AAV gene delivery vectors, a technology that has been clinically validated to target several tissues, enabling an efficient delivery of CRISPR editors to the kidney. Additionally, CRISPR approaches will be designed to restore the physiological expression of the mutated PKD1 gene that causes ADPKD and tested in APDKD mouse and pig models in vivo and in patient-der