RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evaluation of thermohydraulic characteristic of printed circuit heat exchangers in pseudocritical region for supercritical CO2 cycle' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Currently, 28.2% of the total EU-28 greenhouse gas emissions come from the power sector, a large contributor to greenhouse gas emissions. Consequently, the emphasis of the research in power generation has swung towards assessing highly efficient and greener power cycles. In this reference, the novel supercritical carbon dioxide Brayton cycle (sCO2-BC) is an ideal choice that outstrips other formally well-known power cycles (Brayton & Rankine cycles). In sCO2-BC, the role of the pre-cooler is critical. It serves as a sink to the power cycle and regulates the conditions at the compressor's inlet. The compressor's inlet temperature is intended to be maintained close to the critical temperature of carbon dioxide (CO2) to achieve greater cycle efficiencies. However, exceptionally higher values of the specific heat capacity of CO2 near its critical point (up to 40 times higher than water) require exceedingly high water flow rates on the cold side to achieve the desired exit temperatures of CO2. Consequently, the pre-cooler's pumping power requirements become high enough to deteriorate the cycle's performance. This problem can only be mitigated by exploring new channel geometries with enhanced thermohydraulic characteristics. Therefore, the proposed study plan to characterize the complex thermohydraulic characteristics in the pseudocritical region of CO2 using a multifaceted technique that includes, experimental, numerical, and machine learning techniques. The proposed work will provide a step forward to the success of sCO2-BC technologies that, in turn, will facilitate its integration with the green energy resources (generation-IV nuclear reactors and solar concentrated plants), helping to meet the EU's 2030 climate and energy framework goals of achieving at least 32% share f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural targeting of PI4 kinases' (STARPI4K).

assistant: **Innovation**

Phosphatidyl inositol phosphates (PIPs) are biosynthesized from phosphatidyl inositol (PI) by the action of PI kinase. The phosphatidylinositol 4-phosphate (PI(4)P) is produced by the action of phosphatidylinositol 4-kinase (PI4K). PIPs are universal markers of intracellular membranes. Their precise spatial and temporal resolution control enables various protein machineries to operate in the correct location at the exact time. PI(4)P is the single most abundant mono phosphoinositide and is the marker of the Golgi and the trans-Golgi network (TGN). It has been reported to play a key role in membrane biogenesis, vesicular transport, lipid dynamics, and protein and lipid sorting in the TGN. Importantly, the replication of several plus RNA viruses, mainly the Hepatitis C virus (HCV), SARS, and poliovirus (PV) depend on PI(4)P. For instance, HCV hijacks PI4K III alpha to generate endoplasmatic reticulum (ER) derived membranous webs that are enriched in PI(4)P and where the replication of HCV takes place. The main goals of this proposal are (i.) to get structural insight into PI(4)P biosynthesis by solving crystal structure of the PI4K kinase domain and/or the full length enzyme (ii.) to solve the crystal structure of the kinase domain in complex with a small molecule inhibitor like the well known PIK93 (iii.) use the structural information to design novel small molecule inhibitors with higher affinity and specificity that could be used as antivirals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The kinematics and Dynamics of Wave-Current Interactions'.

assistant: **Objectives**

The project has produced the following:- The first set of reliable experimental data for waves interacting with a narrow jet-like current in three dimensions. This includes regular and irregular waves, together with bed stresses in some cases; this bed stresses were only measured for those wave conditions that yielded significant bed stresses. Surface profiles and velocities, mean and wavelike were measured;- One extensive data set in two dimensions. This is concerned with regular and irregular waves and with both following and adverse currents. Bed stresses are measured in some cases, as appropriate, and bed was taken to be smooth, roughened and slatted. Surface elevations and velocities were measured;- A second set of two-dimensional data, with the emphasis on strongly sheared currents. The shear is strongest at the surface and was generated artificially to simulate wind-driven currents. Velocities and elevations were measured for both regular and irregular waves;- Two data sets concerned with three-dimensional motions in wave flumes. Velocity data was obtained across sections of the flumes;- Field data from four sets of tests off the French coast of the English Channel. Two of the four sets are particularly useful and some of the motion is nearly two-dimensional in character;- A number of mathematical models to describe wave-current interactions in two and three dimensions and for regular and irregular waves. These are specific to the prescribed configuration;- Numerical methods to described complete flow motions in two dimensions for regular waves. These simulate the viscous sub-layer and turbulent boundary layer in the vicinity of the bed, the main essentially in viscid domain and the shear layers near the free surface in one model. This represents the leading edge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fully-automated software platform with 3D freeform configurator for design and production of individual and affordable furniture' (3DConfigurator).

assistant: **Innovation**

Mass customization is finding its way into innumerable areas of daily life, e.g. textiles, shoes, as consumer strive for individuality. 84 million customers bout furniture online in the EU. The preconditions for mass furniture are enabled by digitization. Yet there is no solution for affordable individualized furniture representing a tremendous unexploited market.FORMBAR, our novel parametric design software based on mathematical-physical-architectural principles, is the enabling technology allowing customers for the first time to freely shape their furniture individually. In this Phase 2 project FORMBAR will be 100% automated. With simple mouse movements, the customer designs a photo-realistically rendered 3D model and thus constantly inspects his created piece of furniture visually with regard to the selected materiality and colour.By directly integrating the machine specifications into the design process, the self-generated 3D piece of furniture is automatically converted into an optimized cutting pattern and produced cost-effectively using state-of-the-art CNC milling machines. The generated milling data are sent to one of the more than 100 carpenters of OKINLAB in close vicinity to the customer. FORMBAR covers the entire furniture manufacturing process 100% automated, from design to production, in a single application. In combination with mathematically implied algorithms, OKINLAB can guarantee the functionality as well as the producibility of the furniture while at the same time implementing a scalable business model. With FORMBAR mass customization of individual furniture becomes affordable for the first time.OKINLAB with its team of 16 employees from software development, architecture, design, marketing, has developed a configurator in the past selling more than
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intelligent Mediation Environment for Digital Interactive Advertising' (IMEDIA).

assistant: **Innovation**

The iMEDIA project will establish a business and technology framework that will support Suppliers, Advertisers and Consumers in the TV Advertising process. The proposed system will broadcast advertisements comprising video commercials and interactive content (optionally leading to external product catalogues), monitor (upon consumer permission) the interactivity of viewers in order to measure the efficiency of the advertisements and products and finally offer personalized information through a TV set-top x in the consumer household. The applicability and acceptability will be demonstrated and assessed through trials with the involvement of real actors (RAI & ERT). Objectives:iMEDIA will provide an intelligent mediation platform for enhancing consumer and supplier relationships, by establishing the necessary methodologies, practices and technologies for:- The broadcasting of personalized interactive advertising to targeted consumer clusters, providing gateways for access to product catalogues in other digital environments·- The analysis of interactive consumer behaviour for the evaluation of advertising and product efficiency - The empowering of TV audience as interactive viewers and active consumers with total control on their private personal information.iMEDIA major scientific objective is the R&D contribution in the fields of: - Interactive and Point casting Marketing & Advertising: enhance Marketing practices in order to incorporate the feature of interactivity in traditional processes and develop quantitative measurement techniques for interactive advertising.- Consumer Behaviour Modelling: develop models for consumer profiling (consumer on-line identity) and incorporate Consumer Right Protection principals in accordance with EU data protection legislation.- Conver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improvement of sevice life and reliability of cold forging tools with respect to fatigue damage due to cyclic plasticity (COLT)' (COLT), addressing dissemination and exploitation.

assistant: **Impact**

Cold forging is the most efficient technology for mass production of high precision parts for transport, mechanical and electrical industries. There is a large potential for reducing the production costs in this industry by improving reliability of tools. The optimization potential relies on enormous scatter of tool life, which is currently encountered in the production. This is because cold forging tools operate under extreme conditions where slight variations in process load and material strength have a strong impact on tool failure. The main objective of this project is to develop a methodology to increase tool life and to reduce its scatter. Key problems are related to fundamental understanding of the deterioration mechanisms, identification of stochastically relevant process parameters and introduction of such technological modifications in steel making, tool manufacturing and cold forging which will lead to more economical production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Combinatorial Patterning of Particles for High Density Peptide Arrays' in the context of a Seventh Framework call.

assistant: **Objectives**

We want to use selective laser melting to pattern a substrate with different solid micro particles at a density of 1 million spots per cm2. First, a homogeneous particle layer is deposited on a substrate and a pattern of micro spots of melted matrix is generated by laser radiation. Then, non-melted particles are blown away. Embedded within the particles are different chemically reactive amino acid derivatives that will start coupling to very small synthesis sites upon melting the particle pattern in an oven. This is done once all of the 20 different amino acid particles have been glued by laser patterning to the surface. Washing away uncoupled material, removing Fmoc protecting group, and repeating the patterning steps according to standard Merrifield synthesis, leads to the combinatorial synthesis of very high-density peptide arrays. The main objective of this proposal is to develop this method up to the level of a semi-automated synthesis machine. In addition, we will use the manufactured very high-density peptide arrays to readout the information that is deposited in the immune system, i.e. find a peptide binder for every one of the 200-500 antibody species that patrol the serum of an individual in elevated levels. These experiments might lead to novel tools to find out the causes of hitherto enigmatic diseases because then we might be able to correlate antibody patterns with disease status without knowing in advance the disease-specific antibodies. Beyond the life sciences, we want to embed 10.000 peptides per cm2 within an insulating layer of alkane thiols, each on a different gold pad of a specially designed screening chip. Then, we could readout I/V characteristics of individual peptide species, and eventually find peptide-based diodes. These could be modified in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Epilepsy Controlled with Electronic Neurotransmitter Delivery'.

assistant: **Innovation**

Many efficient drugs have been designed to treat neurological disorders, but have failed in the clinic because they were toxic, could not cross the blood-brain barrier, and/or had deleterious side effects in healthy regions. I propose a conceptual breakthrough to solve these three issues, with minimally-invasive organic electronic ion pumps (OEIPs) to provide targeted treatment where and when it is needed. I will use epilepsy as the disease model because of its high rate of drug-resistance (30%) and will offer concrete opportunities for clinical transfer of such state-of-the-art technology.The clinical problem: Resective surgery is frequently the last option available to a patient with drug-resistant epilepsy (> 1 million persons in the EU). However, surgery fails in 30% of the cases and can have deleterious consequences with severe postoperative neurological deficits (impaired motor function, speech and memory). Furthermore, some cases of epilepsy are simply untreatable surgically because resective surgery would leave unacceptable damage to core functions. Clearly, a new therapeutic approach is needed when neurosurgery is not possible or deemed too risky.The OEIP solution: As I have demonstrated, OEIPs combine state-of-the-art organic electronics and pharmacology to control epileptiform activity in vitro by directly delivering inhibitory neurotransmitters on-demand. I additionally demonstrated that thin-film flexible organic electronics can be used to create minimally-invasive depth probes for implantation which significantly reduced tissue damage compared to standard rigid implants in vivo. I will integrate OEIPs on such probes creating devices which will have both the high-quality recordings provided by the organic electrodes for electrophysiological seizure detectio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Why evening-types accumulate health issues and die younger than others?'.

assistant: **Innovation**

Individuals differ in daily timing of sleepwake behavior, alertness, body temperature, cardiovascular functions and hormonal secretion, having innately different circadian types from morningness to eveningness. Evening-types show poorer health already since childhood with increasing severity of health issues at adulthood with major impact on performance/wellbeing and health care burden. However, it is largely unknown WHY health issues accumulate to evening-types. It is likely that underlying factors for health differences between circadian types include interplay between biological, behavioral and environmental factors. Project uses large population-based longitudinal and cross-sectional data across life span from early childhood to old age linked to national register data, including wellbeing and health surveys, objective circadian assessment, health measurements and genetic data. I will study which environmental, behavioral and biological factors influence circadian rhythms and their disturbances throughout life span and how these moderate/mediate the association between circadian type and health/wellbeing outcomes. Focus during early childhood will be in somatic and cognitive development, during adolescence in school adjustment, life habits and somatic/mental wellbeing, and during adulthood in disorders, hospital treatments, and mortality. I will examine the role of genetic predisposition, family/school/work/social environment, life habits and behavioral schedules. Besides the unique and versatile data available for the research, novel objective tools for assessing circadian misalignment is developed in the project. Along with my expertise on circadian research, this project has versatile data and statistical power to sort out whether health issues among evening-type
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strategic Partnership in Transition' (SPRINT).

assistant: **Innovation**

The objective of the proposed “SPrinT” (Strategic Partnership in Transition) programme is to share Polish and Finnish experience in systemic transition and democratization with Egypt in both the political and economic spheres. Though each of these processes has been unique, each also brings with it powerful lessons on the complex nature of transition, reform and transformation which can be beneficial to Egypt. The “SPrinT” will allow the Egyptian researchers to learn about different aspects and models of democratic transformation in Poland and Finland. On the other hand, it will enrich European understanding of the ongoing processes and will allow monitoring closely the changes in the decisive years of a transformation. As the EU acknowledged the need to take on board the societal needs and priorities of its Southern partners, to improve pluralism and inclusiveness in its policies and support democratization, the proposed programme will contribute to shaping the closer EU relations with Egypt.The three think-tanks will exchange 8 researchers and one managerial staffer over a period of 24 months. During the mutual visits the researchers will work both on their own research projects within broadly-understood “transitology” and be supervised by a host institution research programme coordinator to be included in the institution’s work. Joint workshops, seminars and publications are envisaged as well as final product in the form of a book/report project on “Egyptian model of transformation? Comparative analysis”.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Communication and Policy development for Research Infrastructures in Europe' (CoPoRI).

assistant: **Concept**

CoPoRI, Communication and Policy development for Research Infrastructures in Europe,  is a service tool for the European Strategy Forum for Research Infrastructures (ESFRI) to enhance communication and policy development for Research Infrastructures in Europe. It aims to support ESFRI in labor intensive activities e.g. enhancing ESFRIs communication skills, the organization of European workshops. Beyond this CoPoRI will encourage and facilitate discussions and share best practices among ESFRI projects on issues of common interest. It will maximize the scientific return and optimize the use of resources and facilities by sharing relevant developments and results, whenever feasible. CoPoRI will support the outreach activities of the ESFRI projects.