RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hepatocytes-Like Microreactors for Liver Tissue Engineering' under Horizon 2020.

assistant: **Concept**

The global epidemics of obesity and diabetes type 2 lead to higher abundancy of medical conditions like non-alcoholic fatty liver disease causing an increase in liver failure and demand for liver transplants. The shortage of donor organs and the insufficient success in tissue engineering to ex vivo grow complex organs like the liver is a global medical challenge.  ArtHep targets the assembly of hepatic-like tissue, consisting of biological and synthetic entities, mimicking the core structure elements and key functions of the liver. ArtHep comprises an entirely new concept in liver regeneration with multi-angled core impact: i) cell mimics are expected to reduce the pressure to obtain donor cells, ii) the integrated biocatalytic subunits are destined to take over tasks of the damaged liver slowing down the progress of liver damage, and iii) the matching micro-environment in the bioprinted tissue is anticipated to facilitate the connection between the transplant and the liver.Success criteria of ArtHep include engineering enzyme-mimics, which can perform core biocatalytic conversions similar to the liver, the assembly of biocatalytic active subunits and their encapsulation in cell-like carriers (microreactors), which have mechanical properties that match the liver tissue and that have a camouflaging coating to mimic the surface cues of liver tissue-relevant cells. Finally, matured bioprinted liver-lobules consisting of microreactors and live cells need to connect to liver tissue when transplanted into rats.I am convinced that the ground-breaking research in ArtHep will contribute to the excellence of science in Europe while providing the game-changing foundation to counteract the ever increasing donor liver shortage. Further, consolidating my scientific efforts and moving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Unifying Networks for Science and Society'.

assistant: **Objectives**

Mastering networks has become one of the major challenges in modern societies where constantly new links among entities on different scales are created or discovered, ranging from molecules to the interactions of societies on a global level. This has le d to a variety of theories and their applications in different branches of science, from physics and chemistry to ecology and economics. Presently it is not easy to compare different network theories which go beyond the simplest graph theoretical concepts . This is not only partly due to the different scopes of such theories. More often certain concepts have played a more dominant role in specific applications, sometimes due to the set of recordable data, sometimes due to historic reasons acting during the evolution of scientific subjects. We feel strongly that there is currently a need for the unification of network theories for applications in different areas. A major scientific breakthrough can be expected by exploring the concepts of current network t heories in different areas of science. Here mathematics plays a central role in our concept. The unification and generalisation of available results will allow a reinterpretation of transferred theories in the context of different applications. From that  starting point even major improvements of theoretical results are likely which can then again feed back into the different disciplines. We will choose 5 different such specific applications where during this unification theory of feedback cycle" new insi ghts and technological improvements can be expected."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Security Research NCP Network 3' (2014-2020) under Horizon 2020.

assistant: **Objectives**

SEREN3 is a 36-month Coordination and Support Action with the overall aim of facilitating trans-national co-operation among NCPs for Secure Societies, identifying and sharing good practices, and raising the general standard of the support to programme applicants across the EU, Associated and Third countries. To reach the objective above, the project will develop three main activity axes, corresponding to the projects’ specific objectives: 1) capacity building of NCPs; 2) strengthening the participation of relevant stakeholders to Horizon 2020 funding opportunities; 3) and supporting networking opportunities within the Secure Societies constituency. Cross-cutting activities of dissemination and communication will addup to this main set of activities, helping to enhance their impact.  SEREN3 is the continuation and evolution of the precedent network, SEREN2, whose results and lessons learnt have been taken into consideration with the logic of improving the future network and in order to valorize the network’s strengths. SEREN3 will also take into account the paradigmatic change brought by Horizon 2020. This will be reflected in particular in a stronger attention of the network in terms of multidisciplinary competences, consideration of related societal challenges, and linkage with other EU relevant initiatives, funding programmes and policies. Finally, the network will seek further opening to a wider target of stakeholders and businesses in the Secure Societies field. SEREN3 consortium comprises 17 beneficiaries, with a good mix of well-experienced and less experienced NCPs, and representing Member States, Associated Countries and Third Countries. Besides beneficiaries, the project services will be offered to all officially appointed H2020 Secure Societies NCPs, who will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Organocatalytic Coordination Microenvironment Design' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

An overlooked aspect in organocatalyst design relates to nature’s ability to produce a multitude of biochemical products using only a limited number of mechanisms and building blocks. Rather than relying on structural modifications of the catalytically active unit, enzymatic structures primarily vary throughout the coordination microenvironment in which the active unit is embedded. This evolutionary structural principle boosts the number of compounds and reactions that can be efficiently realized by a catalytically active structural motif. In contrast, organocatalysis research has predominantly been focused on systematically modifying catalyst structures while relying on optimization of reaction conditions to provide a suitable microenvironment. Inspired by the breadth of reactions catalyzed by non-metal dependent enzymes, CATACOM aims to boost the efficiency of organocatalysts across a broad chemical space by the a-priori design of directed interactions with their microenvironment. This interdisciplinary research proposal has a computational and experimental component focused on: (1) unravelling the molecular design principles that govern dynamic and non-covalent interactions in organocatalysis using advanced deep learning techniques, (2) showcasing the value of our approach by studying organocatalytic reactions that present ongoing challenges in both efficiency and selectivity. Akin to the remarkable understanding being generated for enzymatic microenvironments, we will construct a representation of the three-dimensional structure formed through the interactions between organocatalytic reaction components by leveraging data on chemical interactions enshrouded in large structural databases. This structural understanding will revolutionize the design of organocatalytic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Humanities in the European Research Area'.

assistant: **Objectives**

During the ERA-NET Specific Support Action in 2004, The European Network of Research Councils in the Humanities (ERCH) has taken several initial steps towards large-scale cross-border coordination of research activities within the humanities. The network h as now in cooperation with the European Science Foundation decided to continue the efforts under a new name: Humanities in the European Research Area (HERA). Building on the ERCH work, the HERA Coordination Action will be an extension of the network, in sc ope as well as depth. Firstly, the Consortium is being extended from three to fourteen members and, secondly, the range of activities is being widened to cover coordination of research activities, including the setting-up of joint research-funding initiat ives. The main tasks of the CA will be: * Consolidation of the network by establishing new network structures and integrating new members. * Exchange of information and best practice on issues such as peer review, programme management, quality and impact assessment, and benchmarking. * The development of research infrastructures within the humanities, which will pave the way for greater efficiency and enable new perspectives by ensuring accessibility and availability for of data and information in the w idest sense. *The ultimate objective of the CA-proposal is to coordinate research programmes in a cumulative process leading to the initiation of joint research-funding initiatives. By applying comparative perspectives to humanities research and enabli ng new transnational funding schemes, it will be possible to transcend the traditional, national focus of humanities research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Land-surface-atmosphere interactions in a winter-time boreal landscape. Planning of a NOPEX winter-time CFE'.

assistant: **Objectives**

The EU Environment and Climate Research Programme has as one of it's main objectives within the field of Global Change to help meet the objectives of the Internafional Geosphere-Biosphere Programme (IGBP), the World Climate Research Programme (WCRP) and the Human Dimensions of Glohal (Climate Change Programme (HDP). The present proposal is part of the multi-disciplinary, European NOPEX project, one out of a few prioritised full-scale land-surface experiments within the IGBP-BAHC framework. Present knowledge about likely climatic change is that the largest influences can be expected at high latitudes and during winter time. This would imply that studies of land-surface-atmosphere exchange should be concentrated to high latitudes and winter time. This has not been the case so far. It has been generally assumed that because of the small net radiative fluxes to the terrestrial surface in winter there has not been very much to. Individual studies have, however, shown that various exchange processes can be important during the winter as well as have large impact on the onset of mass and energy budgets in the spring. The NOPEX organisation includes programmes for Concentrated Field Efforts (CFEs), where a large number of research groups participates in field activities in the NOPEX region during a limited period of time. The Continuous Climate Monitoring (CCM) programme consists of two main field micro-meteorological and actinometric stations together with four research catchments. Two CFEs have been carried out in the spring and summers of 1994 and 1995. Since the main objective of NOPEX is to study the annual and daily cycles of the regional land-surface budgets of energy, water, and CO2, plans have been to perform a third CFE during winter conditions. A full-scale such expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development and validation of a pan-cancer neutrophil biomarker test for predicting clinical benefit from immunotherapy based on flow cytometry analysis of blood samples' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The recent introduction of cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has revolutionised the treatment landscape for a broad range of cancer types. However, response to ICIs varies widely between patients, with the majority experiencing resistance to therapy. Moreover, the increasing use of these costly drugs coupled with management of ICI-related toxicities creates a substantial economic burden. Current biomarker tests for determining eligibility for ICIs have limited predictive performance, and many require invasive tumour biopsies. Thus, novel (and preferentially non-invasive) biomarkers for predicting ICI clinical benefit are desperately needed for better guiding clinical decisions. The NeutroFlow project directly addresses this unmet need. We build on comprehensive academic research describing a flow cytometry assay for measuring a novel predictive biomarker in the blood – Ly6Ehi neutrophil – that accurately predicts therapeutic benefit from ICIs, outperforming the approved PD-L1 biomarker. The NeutroFlow project aims to upgrade the research-level assay to an industry-level, point-of-care prototype test based on a kit comprised of an antibody panel for biomarker detection by standard flow cytometry (FC). Specifically, we will: (i) develop an FC assay according to clinical standards; (ii) develop and clinically validate a computational model that translates FC readout into a prediction of clinical benefit; (iii) evaluate analytical validity of the prototype across three medical centres (i.e., at the point-of-care); and (iv) prepare for future market introduction. The future product represents a minimally-invasive, simple, rapid, cost-effective test performed using standard hospital equipment. As a pan-cancer blood test for accurately predictin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Israeli Patent Law - Theoretical and Comparative Perspective' (2007-2013).

assistant: **Innovation**

The proposed research is aimed at studying Israeli patent law from a theoretical and comparative law perspective.  Unlike the U.S. and the EU, Israel has not seriously considered its patent law policies since the enactment of its 1967 Patent Act and no serious scholarly consideration of the subject has been undertaken since then.The Israeli high-tech sector is widely regarded as a hotbed of cutting-edge technologies, and as the growth engine of the Israeli economy in the 90s and beyond.  Despite the appearance that Israel sprang onto the high-tech scene from nowhere, many factors have slowly melded together to produce an environment in which the creation of high technology has begun to thrive.  Israel also has a very impressive scientific potential in the life sciences.  However, in sharp contrast to the information technology sector, there are no R&D centers of major multi-national pharmaceutical or biotechnology companies in Israel.  Some argue that the patent policy concerning pharmaceutical and biotechnology inventions constitutes a major barrier in realizing Israel's potential in this field.  Israeli patent law needs to be updated in order to provide better opportunities in the biotechnology and pharmaceutical fields as well as sustain a mature high-tech industry.Therefore, the proposed project will focus on examining Israeli patent law from a theoretical and comparative perspective and strive to offer patent reforms initiatives that will modernize Israeli patent law doctrine.  The project will focus attention on the underlying policies of patent doctrines.  While the project is directed primarily toward a legal audience, it will also cover the economic and other policy considerations that frequently control the direction of the law in the area.  These policy discu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Thematic Network Wake Vortex'.

assistant: **Objectives**

WAKE VORTEX PROJECT OVERVIEWWith air traffic growing continuously, the capacity limitation of today s airspace and airports is increasingly concerning the aviation community. Both the airline industry and airport authorities are interested in methods to conduct air traffic in the most effective way without compromising safety.The purpose of the Wake Vortex network is seen in:- promoting a scientific understanding of wake vortices;- gathering and exchanging information about wake-related technological developments;- stimulating research and procedural activities directed toward reducing vortex hazards in the airport and en-route environments. The strategic intention of this network is to contribute to the enhancement of airspace and airport utilisation and the improvement of flight safety.This is mainly achieved by striving for a clearer understanding of all aspects of aircraft-generated wake turbulence and its impact on air transport operation. To this effect, a Thematic Network Wake Vortex identifies, where the greatest know-how deficits exist within the context of wake vortices, and what could be the measures to fill the void. It is generally recognized, for example, that wake characterisation, atmospheric effects, wake detection and avoidance are areas of great concern.EUROPEAN DIMENSION AND PARTNERSHIP The Wake Vortex Thematic Network provides a unique knowledge base available from combined efforts of distinguished institutions within Europe. The project demonstrates European expertise, and aid in obtaining technical excellence in the field of wake turbulence with respect to flight safety.Added value will be created by a number of factors:- Leading European experts, with a wide range of interest in aircraft wakes, will find a forum where they regularly meet to excha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NANODEPOSITION OF ACTIVE ORDERED STRUCTURES BY COLD ATOMS TECHNOLOGIES' (NANOCOLD), addressing dissemination and exploitation.

assistant: **Impact**

The primary aim is the development of atom lithography nanotechnologies based on the deposition of atoms focused by laser light. Final goal is the production of nanostructures in the 10 nm range. Crucial steps are:1) Development of 10 nm depositions on the basis of a common atomic species, caesium;2) Realisation of a flux-enhanced nanopencil;3) Test of laser sources for group III atoms, indium and gallium;4) Deposition of indium and gallium;5) In-situ diagnostics;6) Characterization of the surface processes defining the deposition limit size;7) Fabrication of nanotechnology based devices, e.g; nanometer scale photo-detectors and electron-sources, nano-islands, 3-D photonic crystals. The primary aim is the development of atom lithography nanotechnologies based on the deposition of atoms focused by laser light. Final goal is the production of nanostructures in the 10 nm range. Crucial steps are:1) Development of 10 nm depositions on the basis of a common atomic species, caesium;2) Realisation of a flux-enhanced nanopencil;3) Test of laser sources for group III atoms, indium and gallium;4) Deposition of indium and gallium;5) In-situ diagnostics;6) Characterization of the surface processes defining the deposition limit size;7) Fabrication of nanotechnology based devices, e.g; nanometer scale photo-detectors and electron-sources, nano-islands, 3-D photonic crystals.OBJECTIVESMain objective is the development, assessment and exploitation of the atom lithography technique for the fabrication of nanostructures in the ten nanometres range, for applications in information technology. Major theme is atom lithography of group III materials, as In and Ga, which will open an innovative approach based on the integration with well established deposition methods. Growth control at the a