RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dissemination strategy on electricity balancing for large scale integration of renewable energy' (DESIRE).

assistant: **Innovation**

DESIRE will disseminate practices which will integrate fluctuating renewable electricity supplies such as wind power into electricity systems using combined heat and power. This will allow an increase in pan-European trade in electricity, it will improve the economic competitiveness of both CHP and wind power, and allow the proportion of renewable electricity that can be absorbed by the system to increase throughout the ED.As proportions of renewable electricity rise, so does the threat to pan-European trading in electricity. Trans-boundary electricity inter-connectors will become blocked with international transfer of excess wind power supplies. We shall spread knowledge about the short and long term solutions to these problems. In the short term we can use wind power and CHP plant to co-produce a balanced, non-fluctuating, electricity output. Accumulators are heat stores which enable CHP plant to shift energy production from one time to another.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Small-Molecule Probes of Neuronal Differentiation' (SMOLDIF), addressing dissemination and exploitation.

assistant: **Impact**

Proposal presented herein combines methods of synthetic organic chemistry, cellular neurobiology, and chemical biology to study processes involved in neuronal differentiation. The primary objective of the project is to discover, characterize, and make broadly available high-quality research tools useful in studies of the dynamic processes of differentiation. The outcome of the project is expected to be of immediate value to the basic research in neurobiology, with potential for clinical applications.To perturb the dynamic process of neuronal differentiation, a small-molecule approach will be pursued. Chemical synthesis will play a central role in providing access to structurally complex molecules that are nontrivial to prepare and, partly as a consequence, underrepresented in the commercial vendor libraries. Ability of the prepared molecules to affect neuronal differentiation will be assessed in phenotype-based assay employing physiologically relevant neuronal cultures. Identification of cellular targets binding to the active small molecules will be an integral part of the project and will make use of small molecule-derived reagents and proteomic analysis. A link between the small-molecule structure, neuronal phenotype, and cellular proteins affected by the small molecule, will be instrumental en route to the small-molecule probes of neuronal differentiation.The multidisciplinary nature of the project necessitates interaction among several laboratories, including the applicant’s laboratory for organic synthesis, in order to realize the objectives of the proposal. Establishment of such research environment will catalyze applicant’s integration into the scientific community of Masaryk University in the Czech Republic and development of lasting scientific connections withi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development and implementation in clinical practice of the allogeneic use of thymus-derived regulatory T cells (thyTreg) as a cell therapy to suppress harmful immune responses' under Horizon 2020.

assistant: **Concept**

Cell therapy based on regulatory T cells (Treg) transfer has acquired great interest for the treatment of autoimmune diseases, graft rejection or graft versus host disease (GVHD). Until now, this therapy has not rendered definitive clinical results in humans mainly due to the low number and limited quality of differentiated Treg purified from adult peripheral blood. To overcome these limitations, the host group has developed a new technology to produce massive amounts of GMP Treg derived from the thymic tissue (thyTreg), which are being employed in a clinical trial as an autologous cell therapy in transplanted children. However, the massive amount of thyTreg obtained from each thymus make possible to produce hundreds of doses that could be also employed allogenically to treat a range of immune diseases and patients.  My experience and acquired skills in immunology will provide the host with the adequate knowledge to develop the allogenic use of thyTreg. The goal of my research will be to investigate the immunogenicity of thyTreg and confirm that its immature phenotype makes possible its “off-the-self” use, and secondly to initiate a clinical trial to evaluate the safety/feasibility of a therapy with allogenic thyTreg in patients with GVHD. The project will establish the basis for the development of allogenic thyTreg cell therapies to suppress the harmful immune response underlying autoimmune diseases, transplant rejection, GvHD, and cytokine release syndrome associated with CAR-T therapy or clinical progress in COVID-19 patients. This innovative project will reinforce my expertise in immune disorders, gaining experience in translational research from the pre-clinical stages to the development of clinical trials and transfer of technology. Being part of this host institu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding (harmful) virus-host interactions by linking virology and bioinformatics' (VIROINF) under Horizon 2020.

assistant: **Objectives**

Viruses are currently at the forefront of scientific priorities of many national research councils and the EU. Viruses will remain an urgent topic given the continuously growing and aging global population, creating major challenges for health science, technology and society as a whole. Besides their important role as human and animal pathogens, the beneficial, commensal or harmful functions of viruses are poorly understood. Fundamental questions in virology can only be tackled with the help of bioinformatics. However, the required sophisticated bioinformatics tools are not readily available.By developing and applying tailored bioinformatical tools in important virological models, this ITN, called VIROINF, will provide a better understanding of viruses and the interaction with their hosts, with the aim of giving virologists potent new `weapons' to fight against emerging and established viruses. VIROINF will open the door to develop novel strategies to better understand, treat, and control viral diseases, in addition to understanding the broader ecology and evolution of viruses. The key feature of VIROINF is its interdisciplinary nature, which brings together virologists and bioinformaticians to achieve common goals.The research programme will train a badly needed new generation of young scientists with excellent understanding and skills in virology, cell biology and bioinformatics, to the great benefit and advancement of the field. VIROINF is unique by its special triple supervision in two distinct subjects (virology and bioinformatics) from at least two organisations. Our ESRs will be trained at the very forefront of this rapidly developing field, by gaining state-of-the-art insights into both theoretical and empirical science. The ESRs will be in an ideal position to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Bus System of the Future' (EBSF), addressing dissemination and exploitation.

assistant: **Impact**

The European Bus System of the Future (EBSF) project is conceived as a driver to increase the attractiveness and raise the image of the bus systems in urban areas, by means of new technologies on vehicles and infrastructure in combination with operational best practices, in a system approach. For the first time in European research, these concepts are fully endorsed by all stakeholders, with all major bus manufacturers joining their industrial capabilities along with operators and authorities pooling together in this pre-competitive research project. This project is funded on the consideration that the bus still remains the most universal solution for balanced and sustainable urban development from an economic, environmental and social standpoint, serving 80% of the total European Public Transport. The research will conceive and develop an innovative high quality bus system which will demonstrate the full potential of a new generation of urban bus networks, using state of the art clean vehicular technologies. It will integrate all necessary elements and include a breakthrough design of vehicles, infrastructures and operations placing emphasis on system approach, and identifying the potential for technical harmonisation and standardisation. The project focuses on the bus system in urban and suburban areas. For this reason all the features of the traditional bus services will be examined and developed in conjunction with the relationships between itself and the other modes of transport, in order to concentrate the objectives of the project on the development and improvement of all the characteristics of the EU Bus System of the Future. During its 48 months lifetime, the project will produce several outputs of two main families: Practical and Theoretical deliverables. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoscale 3D Printing of a Lithium Ion Battery: Rethinking the Fabrication Concept for a Revolution in Energy Storage' (NANO-3D-LION), addressing dissemination and exploitation.

assistant: **Impact**

One of the greatest technological challenges of today is efficient storage of electrical energy for portable applications, including electric vehicles, mobile electronic devices, and robotic systems. Further progress in these areas, however, is often hindered by the limitations of current rechargeable lithium ion battery technologies, which are among the most common power sources for these systems. Despite tremendous progress in electrode materials, the intrinsic drawbacks of current batteries are related to their planar two-dimensional design, which restrains the performance in terms of output power and charging speed. NANO-3D-LION is aimed to make a breakthrough in these major battery characteristics by a paradigm shift in battery engineering: the goal is to develop and employ advanced nanoscale 3D printing techniques to fabricate active battery materials with ultrasmall structural features, which will provide almost a thousand-fold increase in the surface area of the battery enabled by nanoscale spacing between its electrodes without compromising the battery capacity. To reach this, high-aspect ratio metal features will be fabricated and further converted into the active material of the cathode and the anode. This will enable unprecedented level of control of the battery architecture, allowing groundbreaking improvement of the key battery performance characteristics, including higher output power and charging times of only several seconds. NANO-3D-LION will establish a unique engineering approach with a potential to completely change the future landscape in research and industry related to portable electronic devices and electric vehicles and will also benefit many technologies beyond battery research, where nanoscale 3D printing opens new unparalleled capacity, ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Releasing the brakes on adult plasticity' (REBOOT).

assistant: **Innovation**

Age-related cognitive impairments compromise the functional capacity of aging individuals, and create major individual and societal costs. Developing means for preserving and restoring cognitive functioning in old age is therefore of great importance. Age-related cognitive impairments have a complex and multifactorial etiology. Pharmaceutical approaches to prevention and treatment have therefore been unsuccessful, and searching for non-pharmaceutical approaches is important. Results of cognitive training studies have so far been disappointing. I hypothesize that the reason for this is that plasticity is functionally inhibited after normal childhood development. Plasticity is then further reduced in aging due to negative brain changes. In this sense, past studies on the effects of cognitive training in adulthood and old age have, so to speak, attempted to push a car that has the brakes on. In a series of experimental studies on humans, my research team will discover feasible ways to release inhibitory brakes on adult plasticity, develop routes to attenuate age-related negative effects on plasticity, and uncover the neural mediators of training-related change in performance, so that the effects of cognitive training can be increased and better understood. Outcome variables include measures of brain function, volume, and integrity acquired using high-resolution magnetic resonance imaging, and up-to-date measures of cognitive performance. Experimental effects on these measures will be evaluated using structural equation models suitable for analyzing repeated measures. This amalgamation of state-of-the-art methodology in the neurosciences and the behavioral sciences bolsters the uniqueness of this research program, which will enlighten the mechanisms of plasticity at neurona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Creating markets for renewable energy technologies a EU RES technology marketing campaign' in the context of a Sixth Framework call.

assistant: **Objectives**

The EU and its Member States have made a clear commitment towards renewable energy sources (RES) and their large-scale penetration and have in recent years created a number of RES policy initiatives, which provide a suitable framework for the development of markets for renewable energy technologies (RET). As far as R&D is concerned, Europe has a long track record mainly through Community programmes in Renewable Energy related R&D, which forms the basis for the outstanding industry development in this area. However, the market uptake of these R&D results is not always happening in the best possible way and therefore needs to be improved. Lack of information and limited use of synergies between stakeholders are still the key critical barriers towards RET market deployment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Resummation of Higher Orders in QCD Perturbation Theory' (RESUQCD) under Seventh Framework.

assistant: **Objectives**

Collisions of highly energetic hadrons play a crucial role throughout much of nuclear and particle physics. They offer insights into the inner structure of nucleons and nuclei, allow studies and tests of the strong interactions and their fundamental theory, Quantum Chromo Dynamics (QCD), and also serve as invaluable tools in the search for physics beyond our Standard Model" of the forces in nature. We propose to perform theoretical and phenomenological studies of hard hadronic collisions. Specifically, we plan to investigate the resummation of large logarithmic perturbative corrections to hard-scattering cross sections in QCD. Our studies would have wide-ranging applications for comparison to data from many present and future experiments in high-energy nuclear and particle physics, ranging from fixed-target experiments to the highest-energy colliders. We plan to improve previous resummation formalisms, develop new techniques and applications, and overall improve the theoretical description of the strong interactions at high-energy."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mimic human complexity in a Beat to revolutionize the drug development' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

BiomimX Beating organs-on-chips (OoC) are in vitro miniaturized and living replica of human organs and diseases,building upon cutting-edge technologies and human cells. Beating OoC provide a faithful replication of native humanphysiology integrating miniaturized 3D cell culture techniques, mechanical stimulation (uBeat®) and electrical recordingcapabilities (uSense). BiomimX’s proprietary key technology (uBeat®) supports 3D human cell cultures and integrates acontrolled and tunable mechanical stimulation system. uBeat® leads to the generation of mature and functional miniaturizedreplication of human organs adequate to test compounds toxicity/functionality in a high-throughput fashion. Integration ofuSense allows real-time evaluation of clinically relevant parameters from the established beating models. BiomimX’sBeating OoC represent a safer, more efficient and faster alternative to poorly predictable preclinical models to date available inthe drug discovery pipeline (DDP). BiomimX already demonstrated the validity of its Beating OoC models in two critical fields ofthe drug discovery pipeline: uHeart (human beating heart-on-chip) has been applied as early predictor of drug functionalcardiotoxicity, uKnee (first in vitro model of human OA) has shown its predictive potential for the discovery of new targets foran unmet pathology.Also thanks to the contribution of Women TechEU programme, BiomimX aims at demonstrating the unprecedented potential of its disruptive innovation in reshaping the market of drug development, by i) boosting technological aspects (i.e. through an intensive industrialization process of BiomimX patented technologies) and ii) proving the versatility of its innovation and its capacity to adapt to a manifold of indications and market spaces. In line with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated AI-Driven Systems For Kidney Transplant Precision Medicine (AI-Care)' (AI-Care), addressing dissemination and exploitation.

assistant: **Impact**

Despite considerable improvements in short-term allograft and patient survival in kidney transplantation in the past two decades, long-term graft survival remains low, with 20% of transplants failing within five years. Rejection remains a leading cause of graft loss, with immediate consequences for patient morbidity and mortality, posing a major burden on healthcare systems. Increased allograft longevity requires improved patient monitoring and rejection risk stratification using mechanistically informed, non-invasive biomarker strategies and precision diagnostics. The main limitation for such an endeavor is the lack of deeply phenotyped cohorts. Given the complexity and heterogeneity of allograft rejection, patient cohorts with sufficient volume, velocity, variety and validity of data are critical in order to capture disease activity, disease stage, improve risk stratification and optimize treatment. Another limitation is the paucity of multidimensional and integrative research strategies. The goal of the ERC AI-Care project is therefore to go beyond the current state of the art by establishing a transplant precision medicine system to 1) facilitate personalized, non-invasive patient monitoring using cell-free DNA technology (Liquid biopsy) 2) improve rejection diagnosis beyond conventional histology using molecular technologies and digital pathology, and 3) gain further mechanistic insights and improve diagnostic accuracy of transplant organ diseases and apply this knowledge to new research areas.