RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of a new CRISPR-Cas3-based tool for large genomic deletions'.

assistant: **Objectives**

The advent of the revolutionary genome editing technique CRISPR-Cas9 has enabled targeted gene mutation, repression, and activation, facilitating impactful biological findings. However, Cas9 as an unbiased DNA deletion tool is limited in its ability to interrogate large regions of DNA of unknown function, because it predominantly generates very small (<20 bp) insertions and deletions at its target site. The capacity to rapidly and efficiently generate large genomic deletions does not currently exist and would be an extremely useful tool for research, allowing for rapid strain engineering of bacterial cells for synthetic biological and metabolic engineering purposes. Additionally, this technology would allow for the interrogation of large segments of non-coding DNA in human cells, much of which has unknown function, but whose variants are often associated with human disease. In this proposal, I aim to develop a Type I-C CRISPR-Cas system employing the Cas3 enzyme (completely distinct from Cas9), which naturally possess coupled nuclease and helicase activity, for high-throughput gene-editing purposes in various prokaryotic, as well as human cells. My preliminary results have shown that this is a credible approach, as I have been able to generate individually, as well as in combination, multiple deletions in bacterial organisms exceeding 60 kb in size. A focal point of the proposal is to adapt this system for use in human cells, which would provide a novel basic research tool with unprecedented capabilities and also could be utilized in human health-related applications. The proposal aims to address this later possibility by utilizing the developed system to treat human cell lines infected with difficult-to-treat pathogenic viruses.


**Keywords:** CRISPR-Cas3, Genetic Eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart Objects for Intelligent Building Management' (SORBET) under Seventh Framework.

assistant: **Objectives**

Intelligent Green Buildings are based on heterogeneous networks of diverse Smart Objects. These cooperate to sense the environment and act autonomously to improve the quality of life of the inhabitants. State of the art Building Management Solutions (BMS) have severe limitations due to closed architectures, limited object interconnectivity and centralized management. Meanwhile, the robust and reliable interconnection of a large number of wireless heterogeneous objects for Intelligent Buildings has not been yet sufficiently explored. These problems urgently call for solutions, in view of the growth of the Internet of Things (IoT), as they are key enablers for the realization of robust management of energy efficient buildings. The need for advancements along these lines demands cutting-edge research and development (R&D) efforts and the renewal and integration of intersectoral knowledge.The SOrBeT project addresses these challenges mobilizing a joint industry-academic group on two complementary areas: (i) Internet of Things and (ii) Building Automation and Energy Management. SOrBeT aims to investigate solutions to leveraging classic BMS systems and developing a highly distributed, self-organizing, platform with reliable and trustworthy machine-to-machine communication as the basis for management of green buildings.In R&D terms SOrBeT builds upon the IoT concept of “reliability by design”. It will thus develop and prototype a state-of-the-art software platform for BMS with a focus on the robust, efficient and reliable communication of large numbers of heterogeneous wireless smart objects. Knoledge-wise SOrBeT contributes to enhancing competitiveness of the partners by a comprehensive transfer of knowledge program. This is designed on a mutual-benefit basis, to promote new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Italian Lauda: Disseminating Poetry and Concepts Through Melody (12th-16th centuries)' (LAUDARE) under Horizon Europe.

assistant: **Objectives**

The lauda, a vibrant expression of popular piety, is the poetic-musical genre that from the second half of the twelfth century marked the birth and the spread of singing in the Italian language. It was based on melodies of varied origins, but mostly functional in orally conveying – through minstrels, lay confraternities and preachers – the dissemination of texts and (not only spiritual) concepts among a largely illiterate population. Despite this ‘volatility’, a good corpus of laude has been preserved in written form for ritual needs, sometimes with musical notation, forming an impressive repository of ‘frozen orality’. While realizing the importance and vastness of this heritage, scholars for over a century have been mainly engaged in alternatively considering it either from a literary or a musical point of view. Therefore, no systematic research has yet to shed light on the specific nature of the phenomenon, its dynamics of creation and transmission and all indicators that make it a reliable mirror of society, culture and mentality in medieval and early Renaissance Italy. The LAUDARE project aims to approach the Italian lauda in its intrinsic intermediality by collecting the whole corpus of texts handed down with music up to the mid 1500s and comprehensively exploring the dynamics of composition and transmission of poems and related tunes according to the mechanisms of orality. An open access database, making searchable the entire corpus, will allow wide-ranging surveys such as the territorial impact of a text and/or its musical setting as well as the diffusion of melodic patterns and text formulas. The results will be collected in a specific volume. Other expected outputs are a handbook, at least ten open access articles, three workshops and two international confere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Design of a new forged banknote detector using magneto resistant sensor for testing of the new european currency : the euro'.

assistant: **Innovation**

Wherever and whenever there is a currency reform, there is fraud. We have the apprehension that the same calamity could happen with the introduction of the new European currency, the EURO. Criminals will obviously be keen to hit the public in Europe with their forgeries before people have got used to the new currency. Today, a few devices exist but are too slow, not automatic, and not reliable (only 96% of efficiency). It is therefore necessary to design and to develop a range of detector with the following features :. 100% reliable because the device will integrate a magneto resistant sensor which will be able to detect the new securities in the EURO banknotes.. Automatic. Customized (one device for the retailers, one for the supermarket, one for the banking). Cheap With the risk of fraud, the exploitation of the results through the target groups of potential users is huge : from the small retailers to the banking. The ambitious of this project is to solve a European problem which will be present in 11 countries in early 2002.This project will furthermore be an opportunity to work in a European scale thanks to the launching of the EURO and the project perfectly to the against the fraud included in Competitive and sustainable growth"."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eye-hand coordination and control: Neural network identification and experimental characterization of the brain's visual-motor reference frame transformation' (2002-2006).

assistant: **Concept**

Eye-hand coordination is the very basis of human behaviour and thus a major issue in Neuroscience. No matter what we do with our hands, vision provides essential information about the movement goal to the motor system. However, in order to produce accurate movements, the brain must take the actual configuration of the eyes with respect to the head and body into account. Indeed, the hand has to move with respect to the arm and the shoulder whereas the target is projected onto the retina. The difference between these 'reference frames' is largely governed by the non-linear mathematics of rotations and the brain has thus to solve this problem to send a precise movement command to the involved muscles. Here, we propose to establish a fundamental framework to exp lain how the brain performs this reference frame transformation problem in eye-hand coordination. We will apply a multidisciplinary approach using mathematical and medical research tools to provide an overall understanding of how the system works. Therefore, we will for the first time establish an algorithmic and a physiologically realistic neural network model to get insight into the computational nature of the underlying brain areas. Resulting hypotheses and predictions will be tested experimentally by performing behavioural studies of eye-hand coordination on healthy human subjects. We will also directly identify the involved neural structures using functional Magnetic Resonance Imaging (fMRI) techniques. The results we expect will have a high impact in t he neural control of movement field because it describes how movement is created accurately. Furthermore, we will provide mathematical and physiological models for the understanding of neural diseases and future theoretical lesion studies. In addition, this firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Between rediscovery and recreation: Renaissance accounts of medieval Italian vernacular literary tradition (1476-1530)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ReMedIt aims to provide the first historical reconstruction of the evolution of views on the medieval Italian vernacular literary tradition in Italy during the period that leads to the formation of an established canon of vernacular literary authors (1476-1530). The project focuses on the reception of the poetic tradition, in particular the extensive Italian lyric tradition (c. 1230-c. 1330) preceding Petrarch, one encompassing over two hundred authors. The project interrogates three main interrelated research strands: 1) the differing value judgements concerning the vernacular poetic past before Petrarch, both implicit ones (such as the selection of poets, their ordering, and the amount of attention afforded them in different poetic anthologies) and explicit comments and judgements; 2) the complex processes – material, interpretative, exegetical and cultural – that bring about the recovery of the medieval lyric tradition and generate knowledge related to it; and 3) the literary influence that this tradition exercised upon verse production during the same period 1476-1530 in the output of nine authors. In order to reconstruct the differing views regarding the genesis and historical development of the earlier Italian literary tradition, the project offers a novel interdisciplinary approach. It does this by integrating the study of how Renaissance poets were influenced by thirteenth- and fourteenth-century authors with an assessment of their critical reception and of the contemporary processes of recovery of their texts. In doing so, ReMedIt will offer a fuller and enriched understanding of this seminal period in the development of the history and codification of the vernacular literary tradition, thereby providing a case study that will be valuable for the study of other
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Biomic_AUTh, Center of Excellence in Metabolomics research'.

assistant: **Objectives**

BiACEM aims to link Biomic_AUTBiACEM aims to link Biomic_AUTh an interdisciplinary laboratory of the Aristotle University Thessaloniki, with three world leading metabolomics research groups: the bioinformatics team of Imperial College London, the metabolomics/lipidomics research team Fundación Universitaria San Pablo CEU (Madrid) and HMGU. Via the realization of the project, strategic partnership and networking will be developed, promoting the research status and capacity of Biomic researchers and covering existing gaps in know-how and technology. Long term aim of Biomic is to lead, develop new concepts, analytical methods, and ways to produce or analyze comprehensive datasets, furthering the application of metabolomics in life science and biomarker discovery. To reach this level, existing pinch points should be addressed. Themes identified as strengths of the advanced partners and key areas of Biomic improvement include: development and organisation of lipidomics experimentation in LC-MS, exploitation of advanced mass spectrometry acquisition and ion mobility spectrometry data, metabolite identification, effective mining and use of multiple data sets, data management, artificial intelligence tools for metabolomics data and for text mining (natural language processing), data fusion, effective biochemical interpretation. Transfer of knowledge is organised as a series of training events, webinars, e-meetings, staff exchanges and collaborative research with the advanced partners. Emphasis is also put on training on research management and setting a research management unit in Biomic. Three clinical biomarker discovery demonstration projects constitute the research element of BiACEM. Realization of the project will have major impact on Biomic, their collaborators and the Gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Organic and inorganic dendrimers - synthesis, characterization, reactivity, applications' (1994-1998).

assistant: **Concept**

Research objectives and content Dendrimers can be defined as multifunctionalized monodisperse polymers whose molecular weigh size, topology, flexibility can be rigorously controlled during manufacturing. These macromolecules offer m wide range of possible applications in a number of areas in chemistry, biology, biochemistry and physics.1,2 The project will involve the study of properties of phosphorus containig dendrimers already prepared in the research group in Toulouse, as well as the preparation of new organic and inorganic dendrimers and hyperbranched polymers. Attention will be focused on the following points: * Functionalisation of dendrimers cavities and chemistry within the cascade structure. * Functionalisation on the core and reactivity of the resulting dendrimer. * Grafting of phosphorus containing dendrimers on star polymers or related macromolecules. * Use of dendrimers in catalysis. * Use of dendrimers as chemical sensors * Synthesis of new organic and inorganic dendrimers. * Characterization of all new compounds ( mass spectrometry, TGA, AFM, dipole moments). REFERENCES 1 J. Issberner, R. Moors, F. Voogtle, Angew. Chem., Int. Ed. Engl. 33, 2413 (1994). 2 N. Launay, A.-M. Caminade, R. Lahana, J.-P. Majoral, Angew. Chem. Int. Ed Engl. 33, 1589, (1994). N. Launay, A.-M. Caminade, J.-P. Majoral, J. Am. Chem. Soc. 117, 3282 (1995). M. Slany, M. Bardaji, M. J. Casanove, A-M. Caminade, J.-P. Majoral, B. Chaudret, J. Am. Chem. Soc. 117, 9764 (1995). N. Launay, M. Slany, A.-M. Caminade, J.-P. Majoral, J. Org. Chem. 61, 3799 (1996). Training content (objective, benefit and expected impact) Professor Majoral is an expert researcher in the field of dendrimers. The variety of uses for dendritic macromolecules has aroused my interest in these species. On the other han
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HYDROCARBON EXPLORATION RISK REDUCTION THROUGH BETTER ATTENUATION OF FREE SURFACE MULTIPLES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project will introduce a robust free surface multiple attenuation technique which performs better than conventional techniques. The new method involves the integration of new marine seismic source control and inverse scattering theory multiple attenuation technologies. The inclusion of additional sea bottom reflection and source behaviour information, made possible by the new source control system, will enhance the general performance of the inverse scattering multiple attenuation method. Present implementations of inverse scattering multiple attenuation methods fail for data acquired in water depths less than 200 m. This project will allow us to test and demonstrate that inverse scattering multiple attenuation can be applied successfully to data from shallower water depths if additional data from the new source control system is used, extending its applicability from 10% up to possibly 90% of European marine hydrocarbon bearing areas. The shallow water limit of the integrated data acquisition and processing multiple attenuation method is one of the principal unknows being sought by this programme.During the second reporting period of the project, the seismic survey to acquire real data for the first shallow water multiple attenuation demonstration was planned and completed. Neither BP nor ARCO British were able to find a suitable survey in their 1996 schedule which fulfilled the characteristics required for either of the two multiple attenuation demonstrations described in the project plan. Geco-Prakla Marine Operations (Geco A/S), therefore, acquired the test data during one of their Non-exclusive Proprietary Surveys (NEPS). A single 2D seismic line was planned, to be acquired in the Dutch sector of the North Sea in Quads D-E. The water depth ranged from 35 m at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Truth, Truthlikeness, and Trust: Shaping Reality in Ancient Near Eastern Societies'.

assistant: **Concept**

The TANES project, Truth, Truthlikeness, and Trust: Shaping Reality in Ancient Near Eastern Societies, investigates why formal truths were established and how misinformation was used in Old Babylonian (OB) documents (2003-1695 BCE). Through interdisciplinary approaches, it aims to redefine our understanding of truth construction in ancient societies, significantly impacting both Assyriology and broader studies of historical information dynamics. As Van McGhee notes, truth is essential for understanding group and individual behavior. In ancient societies, truth's socially constructed perception validated interpersonal bonds, with trustworthiness of information and its conveyors crucial for the stability of political, religious, and social groups. However, the authenticity of information often conflicted with its intended use.The project explores the concept of ""truthlikeness,"" introduced by Karl Popper, which allows for varying degrees of informational manipulation. This focus shifts from traditional truth (factual reality) to a strategic use of truth and misinformation that served specific social and political purposes in Mesopotamian society. OB documents, especially from the royal archives of Mari, show how truth was shaped to influence decisions and maintain social order, often relying on trust in supernatural validations rather than factual accuracy. The project analyzes a carefully selected corpus of political correspondence and legal documents to uncover the deliberate manipulation of truth and the role of trust. This examination includes rhetorical strategies, performative speech, and the construction of socially accepted truths within OB political and legal contexts. TANES seeks to break new ground by applying contemporary theories of truthlikeness and informa