RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Lessons from history - the classical gold standard and its performance for the core and peripheral countries' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Recent research in monetary history confirmed that the gold standard worked successfully for the core countries on the classical gold standard. The interaction within and between the core countries (strictly followed the gold standard) and the peripheral countries (shadowed the system) offer a fruitful area of research. Comparisons can be made on a wide range of economic subjects including inflation volatility, seigniorage, exchange rate analysis and risk premia on long-term securities during the periods of convertibility and suspension for both core and peripheral countries. Therefore, this project proposes studies on the classical gold standard and its performance for the core - the northwestern European countries - and the periphery - Scandinavia and the Southem European countries of Spain, Italy and Portugal. Training content (objective, benefit and expected impact) The purpose of this research is to provide additional insight into the operation of the classical gold standard in the core and peripheral countries of Europe. The relevance of the proposal is not only of interest to economic historians but to policy makers in the European Community. The conclusions drawn from it have implications for the current economic issues that are taking place in Europe nowadays related to the European Monetary System. Furthermore, this project will expand my knowledge for future academic research and add to my statistical tools. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Photocatalytic reduction of carbon dioxide into fuels'.

assistant: **Concept**

A promising research area, which could provide a solution to the high energy demands of our society, as well as to the devastating effects of greenhouse gases, has arisen from the idea of using CO2 as chemical feedstock for fuel production. The capture, conversion and storage of a sustainable, clean and secure energy represents an important multidisciplinary research area.The goal of artificial photosynthesis is to mimic the conversion of water and CO2 under solar irradiation, carried out by plants and other bacteria, to obtain high-energy chemicals for energy production. Light induced water splitting and CO2 reduction devices at a molecular level require the integration of at least three essential components in a stable supramolecular architecture: a photosensitiser, a water oxidation catalyst and a CO2 reduction catalyst. An interesting way for the incorporation of this catalytic system in a complete functional device is the so called dye sensitised photoelectrochemical cell. In this device, the oxidation and reduction reactions take place at the anode and cathode electrodes of an electrochemical cell.The aim of this proposal is the development and study of an efficient photocathode, composed of a photosensitiser, a semiconductor support and a catalyst for the reduction of CO2 into fuels. This electrode will then be integrated into a new molecular-based device able to produce high value chemicals such as CH3OH or CH4 from CO2. A clear advantage of this innovative scheme is that it allows the study of the kinetic reactions that occur at the CO2 reduction electrode and the mechanisms of the photochemical CO2 reduction in an independent system. The final device will be prepared as a composition of two different sub-systems: for water splitting and CO2 reduction. The elec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New BIOtechnologiCaL approaches for biodegrading and promoting the environmEntal biotrAnsformation of syNthetic polymeric materials' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In BIOCLEAN project, novel and robust microorganisms (aerobic and anaerobic bacteria, and fungi) able to extensively degrade polyethylene (PE), polypropylene (PP), polystyrol (PS) and polyvinyl chloride (PVC) polymers and plastics will be isolated from actual-site aged plastic wastes obtained from several European marine and terrestrial sites, composting facilities and landfills, and obtained via tailored screenings from existing European collections of microbes. Robust enzymes able to fragment the target plastics with the production of valuable chemicals and building blocks will be obtained from the selected microbes and enzyme collections. Untreated and physically/chemically pre-treated PE, PS, PP and PVC polymers and plastics will be employed in such isolation/ screening activities, and an integrated methodology, relying on advanced analytical methods (determining plastics physicochemical changes and breakdown products resulting from biological attack), and tailored enzymatic, microbiological and ecotoxicological methods, will be adopted for the characterization of actual industrial relevance of the obtained microbes and enzymes. Physical and chemical pretreatments improving biodegradability of target plastics will be identified and transferred on the pilot scale. The most promising microbial cultures and enzymes will be exploited in the development of pilot scale, slurry or solid-phase bioprocesses for the bioremediation and controlled depolymerization, respectively, of target pretreated plastics and in the set up of tailored bioaugmentation protocols for enhancing plastic waste biodegradation in marine water systems, composting and anaerobic digestor facilities. The processes developed will be assessed for their economical and environmental sustainability. Field sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Evolution of Novel Contacts in Orthologous Regulatory Elements'.

assistant: **Innovation**

Thousands of Conserved Non-coding Elements (CNEs) are shared by jawed vertebrates, some of which were shown to be important developmental enhancers. However, how these intriguing elements evolve at the functional level and why they are so conserved in sequence remain some of the biggest mysteries in the field of regulatory genomics. In this project, I build a novel view of CNE function and evolution based on my preliminary data and recent breakthroughs on enhancer pleiotropy. This working hypothesis posits that CNEs are ancient transcription factor binding hubs that act as dynamic multi-genic regulators to which new gene targets can be added/removed during evolution. Taking advantage of the exceptional conservation of CNEs, I propose the experimental framework to test this hypothesis on orthologous elements across major vertebrate clades using cutting-edge methodology combining Capture-HiC, RNA-seq and ATAC-seq in shark, chicken and mouse. This approach will provide comparative CNE-target contact maps that will reveal conserved as well as gained and lost interactions in each species, whose functional impact will be tested using CRISPR knockout and interference in mouse neuronal differentiation. In summary, this project will address long-standing questions on the evolution of the regulatory genome and offer insights into the flexibility of enhancers to acquire and lose targets in evolution, expanding our understanding on the pervasiveness and evolution of regulatory pleiotropy.


**Keywords:** evolution,gene regulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dreamspace: A Platform and Tools for Collaborative Virtual Production' in the context of a Seventh Framework call.

assistant: **Objectives**

Dreamspace will research, develop and demonstrate tools that enable creative professionals to combine live performances, video and computer-generated imagery in real time and collaborate to create imaginative entertainment and experiences.The film and TV industry is seeking ways of producing audiovisual media that combine the real world, CGI and 3D animation in real time, at a quality sufficient for major movies, but at a cost that is accessible to European film and TV companies. Meeting the demand will need advances on the state of the art in a wide range of areas, including the combination of 2D and 3D methods; depth and lighting capture; surround video; real-time depth-based processing and compositing; real-time high resolution rendering; and new approaches to manipulating CG objects and video in a virtual environment.The ability to assemble, try out, play with and even improvise virtual productions will have profound creative consequences for the media industry, performance groups and creative artists. One part of the Dreamspace ambition is therefore to make it possible for directors, designers and artists to build experiences directly from visual components, working together on set or in the performance space, and see the results immediately. The other is to explore and develop ways of using Virtual Production technologies to deliver new creative experiences.The goal is to create an environment and tools that make it possible to work with and combine all the elements in real time, at a high level of quality. We want to realise a 'dream machine' in which artists can drag and drop real world scenes and CGI to produce fusion worlds; move and control digital characters and scenes to explore and develop a story; switch viewpoints effortlessly, to see the action from the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Experimental investigation of generating multi-particle entanglement with neutral Atoms'.

assistant: **Objectives**

We plan to experimentally develop a quantum tweezer to extract a certain number of atoms from a Bose-Einstein condensation (BEC) cloud and to investigate the possibility to detect with certainty freely propagating atoms on the single-atom level. On this basis we are going to explore the feasibility to generate and detect multi-particle entanglement by exploiting atom-atom collision and linear optics.In my project, we start with a trapped Bose-Einstein condensation (BEC) ensemble. From which, we can extract a definite number of atoms at will with a quantum tweezer, which may be generated by a focus beam of red-detuned laser light. After having successfully extracted two atoms, the quantum tweezer is switched off non-adiabatically, which correspond s to a decay of a two-atom system, so that the two atoms will freely propagate along correlated directions. That is to say, the freely propagating atoms will be entangled in the momentum space.In order to verify the successful generation of entanglement, we will develop an imaging system to detect the single atom with nearly 100% certainty. We shall then carry out observation of entanglement by combining the atoms along different ways at their corresponding 50:50 atomic beam splitters. Depending on the outcome of these experiments we will assess the quality of two-atom entanglement such that, we know whether it can be used to perform both the fundamental tests of quantum mechanics versus local realism and the quantum information processing.The possible next step will be investigating the generation of multi-atom entanglement. Since single atom detection efficiency can reach to 100%, an experimental generalization of linear optics quantum information processing to the atomic domain would open up the new perspective for the futur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LAttice COdiNg for multiuser wIreless Communications', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In the last decade, the wireless industry has witnessed an impressive growth worldwide. Advances in wireless technology have enabled a wide range of applications, from third generation (3G) mobile phones to new local area network and broadband standards such as WiFi and WiMAX. The demand for high-speed mobile capability continues to increase, with new standards being developed such as LTE and 4G.New communication paradigms are being introduced to exploit the capacity of wireless systems. Due to the shortage of licensed spectrum, multiuser systems are emerging as an alternative to time-sharing, enabling terminals to share bandwidth.The LACONIC project, to be carried out at Imperial College London by Dr Laura Luzzi (fellow) and Dr Cong Ling (host), aims at designing high-performance codes for the multiuser case, by addressing LAttice COdiNg for multiuser wIreless Communications. It is inspired by the recent breakthrough in network information theory, which has shown the significant theoretical potential of lattice codes. The project will realize this potential by constructing explicit multiuser lattice codes. It will focus on two main scenarios: the multiple access channel and the interference channel.A great challenge for the practical implementation of lattice codes is the complexity of decoders, which entails a prohibitive computational load for mobile devices. The project will develop low-complexity decoding algorithms which exploit the algebraic properties of the codes.Mathematical tools play a prominent role in the design of high-performance codes. Thus, the LACONIC project will benefit from an interdisciplinary study of recent techniques in the fields of number theory and cryptography.The proposed fellowship will enable Dr. Luzzi to widen the scope of her research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Glycosylation engineering for novel antobiotics' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Medically-important polyketide antibiotics produced by streptomycetes often contain deoxysugar residues essential for their function. Altering these sugars would be a powerful route to new antibiotics. Increasing microbial resistance makes this an urgent need. This proposal is to study production of novel glycosylated polyketides, using knowledge of the biosynthetic pathways to deoxyhexoses (6-DOH). The word includes:1) complementation of mutants in deoxysugar pathways to generate hybrid glycosylated compounds2) Production of hybrid antibiotics by adding aglycones to cells containing gene sets specifying synthesis of a deoxysugar, together with cloned glycosyltransferases (GTases)3) use of enzymes for synthesis of 6-DOH in production of activated substrates for Gtases4) use of purified GTases with activated deoxysugars, for biotransformation of aglycones 5) DNA shuffling of GTases genes and selection in vivo for bioactivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Function and malfunction of the prion protein' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Transmissible spongiform encephalopathies (TSE) are caused by the ordered aggregation of PrPC into prions consisting of PrPSc. Similar pathogenetic principles operate in Alzheimer’s and Parkin-son’s disease, and a growing list of further diseases whose prevalence is steadily rising. Familial TSE are invariably associated with PrPC mutations, and the dearth of genetic modifiers has hampered our understanding of prion diseases. Therefore, the first objective of my proposal utilizes a cell-based high-throughput quantitative prion replication assay (developed during my previous ERC instalment) for genome-wide unbiased screens employing new genetics tools (CRISPR, siRNA li-braries, next-gen sequencing) to identify modifiers of prion uptake, replication, and secretion. The second objective aims at clarifying the basis of prion neurotoxicity and will be developed along two alleys: (a) we will uncover the molecular basis of spongiosis (the neuronal vacuolation characteristic of prion diseases), which we suspect to be a main driver of pathology, and (b) we will perform CRISPR-based synthetic lethality screens to identify genes that become essential to prion-infected cell lines (which do not experience prion toxicity) and may not be expressed by neurons. The third objective is to understand the function of PrPC in cellular physiology, and focuses on our evidence that (a) PrPC interacts with an orphan G-protein coupled receptor to maintain peripheral myelin integrity and (b) that PrPC may trigger cell death in response to ER stressors. While certain pathways of degeneration will undoubtedly be specific to prion infections, I expect that some targets will prove common to a variety of protein aggregation diseases including Alzheimer’s and Parkinson’s disease, and may perhaps transla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Steam injected diesel engine - stid' in the context of a Fifth Framework call.

assistant: **Objectives**

To develop and test a new combined diesel and steam process. High temperature and high-pressure steam will be injected into the combustion chamber. By utilising the air and cylinder cooling and exhaust heat to generate steam, the method has a potential of a substantial increase of the thermal efficiency (reduction of CO2) and at the same time control the formation of emission (NOx). A medium risk project that needs generic innovative research in spray combustion with high concentration of steam. A full-scale laboratory engine test will determine if the STID combustion concept is viable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Optical dissection of cortical dopamine signaling'.

assistant: **Objectives**

Coordination, execution and learning of skilled movements strongly depend on motor cortex function, which, in turn, depends on the modulatory action of different neurotransmitters. In particular, dopaminergic inputs to the motor cortex have been associated with synaptic plasticity, changes in cortical excitability and modulation of cortical motor maps. The integrity of dopaminergic terminals is required for the acquisition of novel motor tasks, but not for the performance of already learned ones. Despite evidence pointing to the importance of dopamine in the learning of novel motor skills, technical limitations have impeded solving several key questions. For instance, what are the exact behavioral conditions leading to dopamine release in the motor cortex during skill learning? Are dopamine fibers in the motor cortex synchronously activated affecting large cortical areas? Is dopamine necessary and/or sufficient for cortical motor learning? I will address these questions by combining my expertise in the field of dopamine signaling with the use of novel optical techniques recently developed by the European host institution and thereby dissect the role of dopamine with never-before-reached level of spatio-temporal accuracy. Specifically I aim to use in vivo two-photon imaging and optogenetic manipulations of genetically targeted dopamine axon terminals in the mouse motor cortex in combination with quantitative behavioral testing and characterize their role in the learning of novel motor skills. By recording and manipulating dopamine axon activity in the motor cortex I will test the hypothesis that dopamine acts as a necessary global signal of reward prediction error at the motor cortex level. This project will provide novel insights in the exact contribution of dopaminergi