RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative weather presentation on television' (WEPTEL).

assistant: **Concept**

The objective of the project is to introduce innovative weather presentations on television.For this purpose a visualisation system will be developed which is able to select fast and on-line interesting phenomena produced by weather forecast and air-pollution models, and combine the output of these two models. Furthermore, the system - and thereby the numerical models used in the project - should be able to provide forecasts for areas varying from a regional scale to a continental scale. Finally, state-of-the-art visualisation techniques will be included in the system to introduce novel methods to present forecast phenomena ( e.g., three-dimensional data, time-series, virtual scenery).The project addresses the embedding of High Performance Computing and the post-processing of data generated by simulation into a commercial end-user application. The post-processing needs for high performance computing and related visualisation of high volume data are considered one of the major challenges for high performance computing to gain a market position beyond scientific computing. This project distinguishes itself by the fact that the post-processing needs do not cater for scientific computing and high performance computing experts but rather for an audience of non-experts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'RNA-mediated Transcriptional Gene Silencing in Humans'.

assistant: **Innovation**

More than 70% of the human genome synthesizes non-coding RNA that is believed to regulate gene expression. While there is ample evidence from model systems that small RNAs are the lynchpin of powerful mechanisms that silence transcription, the demonstration of transcriptional gene silencing (TGS) mediated by a small RNA in humans is lacking. We have recently shown that the HIV-1 LTR is controlled by premature termination of transcription and TGS mediated by a small RNA derived from the stem-loop structure, TAR, that forms the 5’ end of HIV-1 transcripts. This pathway depends on Microprocessor, Xrn2, Setx and Rrp6. Cleavage of TAR by Microprocessor has major consequences 1) it provides a substrate for Rrp6, which generates a small RNA that represses HIV-1 transcription, 2) it creates an entry site for Xrn2 and termination factors that lead to premature termination of transcription. Loss of Microprocessor or Rrp6 leads to recruitment of RNAPII to the LTR and activation of transcription. These findings not only provide the first evidence showing that small RNA-mediated TGS acts in human cells, but they also uncovered a new mechanism of gene regulation involving premature termination of transcription by RNAPII. Several important questions now need to be answered. What is the mechanism underlying small RNA-mediated TGS? Does small RNA-mediated TGS operate at human genes? What is the contribution of TGS coupled to premature termination in the global control of transcription? We will use a battery of biochemical and molecular approaches to dissect the molecular mechanism of RNA-mediated TGS. The global importance of small RNA-mediated TGS and premature termination of transcription in the control of human gene expression will be addressed using complementary genome-wide approac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Remoteness and Connectivity: Highland Asia in the World' in the context of a Horizon 2020 call.

assistant: **Objectives**

Asian highlands from the Afghan Pamir to Kashmir, Tibet and Northeast India are of great geopolitical concern. Remote, yet thoroughly connected to the outside world, they figure in public debate alternately as sanctuaries for transnational insurgents, as trafficking routes in the global drug and wildlife trade, and as realms of authentic tribal culture. Though making headlines around the globe as independent cases, we lack a conceptual understanding of their entanglements, role and position in a globally connected world. The aim of this project is to lay the conceptual groundwork for a new apprehension of the positionality of remote areas around the globe. It rests on the hypothesis that remoteness and connectivity are not two independent features but constitute each other in particular ways. My objective is to explore the nexus of remoteness and connectivity – a fundamental dynamic that has never been studied from a comparative, transnational perspective. Highland Asia, the chosen study area spanning the mountain regions between Pamir and Eastern Himalaya, transcends the boundaries of nation-states and area studies. It offers a unique vantage point to reveal a bigger picture.The project is timely. 25 years after the end of the Cold War, Highland Asia experiences a rapid increase in transnational exchange. Old trade routes closed for generations are being re-opened and the quest for natural resources and new markets attracts capital and new actors to the highlands. The hotspots of tension at the edge of Asia’s rising powers are becoming junctures of exchange. The project studies this ongoing but little understood transformation in real time.The project will be carried out by an international team of four researchers at LMU Munich. Interdisciplinary in outlook but ground
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Self-feeding implants to improve and accelerate tissue healing using nutritional nanoparticles' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Keeping large (>1cm3) living tissues alive is an unresolved key challenge that hinders many clinical and industrial applications, including tissue/organ transplants, engineered tissues, drug screening models, and lab grown meat. While natural tissues within our body are continuously provided with nutrients via the blood stream, engineered, explanted, or even implanted tissues have to rely on the slow diffusion of nutrients until perfused vascularization is achieved. This commonly leads to tissue starvation, which inevitably causes tissue failure. The NutriBone project is based on the logical yet never before explored premise that these tissues need to provide their own nutrients if the environment cannot do so. This is an innovative concept named self-feeding. We have surprisingly discovered that glycogen offers cell-driven long-term release of physiologically relevant quantities of glucose enabling long-term implant survival, accelerated tissue formation, reduced inflammation and immune responses, and improved vascularization. As this approach is a first-of-its-kind, we have patented it and here propose its valorisation.We propose to develop a marketable self-feeding bone implant to address the current clinical challenge of critically sized bone defects. Although our technology is relevant for many clinical applications, we will focus on large bone defects. Bone is the second most implanted tissue but implant failure remains high, leading to high medical cost and low quality of life for patients. Moreover, bone implants represent the largest, and still fast growing market for engineered tissues, while awaiting a solution to maintain implant viability. Thus, we can foresee a concrete path-to-market. To this end, we will perform product development towards a minimum viab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Habitat choice and preferences of cetaceans in the western Ligurian Sea: insights through telemetry and satellite imagery' to be submitted under Fifth Framework.

assistant: **Abstract**

Investigation of the habitat use and preferences of cetaceans living in the Western Ligurian Sea, by correlating their presence with satellite derived data and other environmental parameters. Foraging behaviour and migratory movements will also be investigated through the use of satellite telemetry. The provided information will be used for the management and conservation of these mammals in heavy anthropic habitats.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Proteomics approaches to identify new vaccine candidates against group B Streptococcus', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

During the last century, several approaches have been used for the development of vaccines, ranging from the immunization with live-attenuated bacteria up to the formulation of the safer sub-unit vaccines. These conventional approaches to vaccine development require cultivation of the pathogen and its dissection using biochemical, immunological and microbiological methods. Although successful in several cases, these methods have failed to provide solutions against many human pathogens. With the impressive progress of bio informatics and high throughput protein expression, three new areas, genomics, transcriptomics, and proteomics, have emerged with the potential to enormously speed up the vaccine discovery process. Each of these approaches leads to the selection of the most relevant proteins for the induction of protective immune responses, e.g. membrane-associated proteins, secreted proteins and virulence factors. Genomic involves the sequencing of a given bacterial genome and the use of various algorithms to predict which genes potentially code for membrane-associated and virulence-associated proteins. Transcriptomics is of particular interest to define virulence factors. It uses DNA micro arrays to measure bacterial gene expression in response to host/pathogen interaction. Proteomics allows the direct identification of potential vaccine candidates through the separation of bacterial membrane-associated proteins (usually by two-dimensional electrophoresis), and the iridentification by mass spectrometry. Once selected, the potential vaccine candidates are expressed and purified in a high throughput setting and the purified antigens are finally tested in correlate-of-protection assays to select the most promising vaccine candidates. The availability of a large collectio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovation Management Support for SMEs' to be submitted under Horizon 2020.

assistant: **Abstract**

The general objective of the described actions is to contribute to smart growth in the European Union by increasing the efficiency and effectiveness of investments in research, development and innovation and by contributing to a better and more efficient connection of actors along the innovation chain.To achieve the above mentioned objectives the proposed grant shall: a) Identify bottlenecks to the creation of economic impact in companies benefitting from grants by Horizon2020's SME instrument and address these bottlenecks with the help of capable coaches. This service to beneficiaries of the SME instrument in the context of a giving project is called 'Key account management'. b) Increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support to research and innovation but would not have effective access to consulting services for innovation management. This service, provided independently from a specific innovation project and focussing on a company's innovation management system, is called 'Enhancing the innovation management capacity of SMEs


**Keywords:** Innovation Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Directed crop breeding using jumping genes' (BUNGEE).

assistant: **Innovation**

The rapidly changing climate puts commonly used crop plants under strong pressure. It is therefore essential to develop novel breeding technologies to rapidly enhance crops to better withstand newly emerging stresses.Interestingly, a clear link between transposable elements (TEs), crop improvement and varietal diversification exists. Furthermore, in recent years the importance of (TEs) in evolution and adaptation to stresses has been recognized. However the use of TEs in crop breeding is currently very limited because it is not possible to control TE mobility. My research group has identified a novel highly conserved epigenetic silencing mechanism that represses the activity of TEs in Arabidopsis. We also found drugs capable of inhibiting this mechanism. Because these drugs target highly conserved enzymes we were able to show that our drug treatment is also effective in rice. We are therefore able to produce TE bursts in a controlled manner in virtually any plant. We can thus, for the first time, generate and study TE bursts in crop plants in real time. More importantly, we found that the accumulation of novel insertions of a heat-stress inducible TE produced plants that, at a high frequency, were more resistant to heat stress. This suggests that the stress that was initially applied to activate a specific TE in the parent, lead to an improved tolerance to that specific stress in the progeny of that plant in a very straight-forward manner. In this project I propose to accelerate plant breeding by testing and implementing a revolutionary TE-directed crop improvement technology. For that I plan to 1. Mobilize TEs in crop plants using selected stresses 2. Using these mobilized stress-responsive TEs breed novel crop plants resistant to those selected stresses and 3. Study t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The diagnostic potential of miRNAs for early diagnosis of Systemic Sclerosis'.

assistant: **Concept**

Systemic sclerosis (SSc) is a life-threatening autoimmune connective tissue disorder of unknown cause, characterised by fibrosis of the skin and internal organs. SSc affects approximately 160.000 patients worldwide and is associated with life-long burden of disease. Early detection of SSc is currently impossible as diagnosis is typically based on a combination of late-stage clinical symptoms. Current diagnostics, however, are based on late clinical manifestations. There is a need for actionable biomarkers for early-stage diagnosis and disease monitoring.Based on proprietary ERC research specific microRNA (miRNA) profiles were found that positively correlates with clinical progression and complications of SSc. Its expression was elevated in subjects who demonstrated symptoms that can precede SSc onset by years. These findings provide strong support for the prognostic and diagnostic properties of the miRNA panel in SSc. MIRASYS has been designed to accelerate the commercialisation of a panel of highly potent miRNAs that have breakthrough diagnostic potential in SSc. MIRASYS will be used to validate these findings by setting miRNA expression level boundaries for SSc development and to incorporate these in a diagnostic assay. MIRASYS will also assess the commercial feasibility of setting-up a dedicated spin-off company to commercialise the technology. The team has analysed the IP landscape for similar approaches for SSc and no prior art on the specific miRNAs was found. In the MIRASYS ERC PoC Grant, the team will further investigate the IP position and formulate a strong IP strategy including the steps towards full Freedom to Operate.The MIRASYS team consists of experienced science and business professionals. The team has developed several business models which need to be a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transitioning Applications to Ontologies' to be submitted under Sixth Framework.

assistant: **Abstract**

Semantic Web Services (SWS), and Service-Oriented Architectures (SOA) that host them, are about to make a significant contribution to the competitiveness of European ICT. This will happen in two ways. First, Enterprise Applications Integration (EAI) will become less costly and more reliable because of explicit modelling of the meaning of data and processes in the systems owned by different business units. Second, B2B and B2C eCommerce systems will become: more reusable, with interfaces that are meaningful for machines as well as for humans; more dynamic and adaptive, with the possibility of virtual applications composed from dynamically discovered components; more scaleable, distributed across multiple machines; saleable as discreet elements in the application service providers market. TAO is about how existing legacy" applications can migrate to open, semantics-based SOA. We will create an open source infrastructure to aid transitioning of legacy applications to SOA, via ontologies and refactoring into SWS. This will enable a much larger group of companies to exploit semantics without having to re-implement their applications. The results will be validated in two high-profile case studies: a comprehensive open source platform (with thousands of users) and a data-intensive business process application (managing a multi-million business). Now is the time to do this, because significant recent initiatives have built up strong foundations for practical semantic SOA. They have shown how new systems can profitably deploy semantics as a lingua franca for modelling the points of contact between software components at a higher level than previous technology. Now we need to show how existing applications can profit from semantics-based architectures. TAO will ease the adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'COntroller adaptive Digital Assistant'.

assistant: **Concept**

COntroller adaptive Digital AssistantThe CODA project involves developing a system in which hybrid human-machine teams collaboratively perform tasks. To do so, the system put together state of art from different fields: i) Prediction models to foresee future situations and have the system know which activities will be carried out by the operators and their impact on the same human performance; ii) Neurophysiological assessment of mental states to enable the system to know operators real current level of workload, attention, stress, fatigue, and vigilance by validating the predicted cognitive models and maximising the effectiveness of the interaction between the human and the machine by developing an HMPE (Human Machine Performance Envelope); iii) AI-based adaptable and explainable systems, to have the system act to prevent future performance or safety issues.Specifically, the project will show how a system could adapt to specific situations and react accordingly by using advanced adaptable and adaptive automation principles that will dynamically guide the allocation of tasks. The system will assess the operator's cognitive status, use current traffic data to foresee the future tasks that the operator will need to perform in the future, and calculate the impact of those tasks in terms of cognitive complexity. With this information, the system will predict the future mental state of the operator and will act accordingly by developing an adaptive automation strategy. For example, imagine an ATCO managing a complex traffic situation and experiencing a medium workload. The system is aware of this (thanks to the neurophysiological assessment). It predicts that the additional upcoming tasks the ATCO will need to take care of will increase their workload, exceeding the maximum