RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multiscale Simulations of HIV capsid assembly and RNA' in the context of a Horizon Europe call.

assistant: **Objectives**

In this project, I will perform computer simulations and develop new computational methods to elucidate viral functions and RNA. The first two years will take place in the group of Prof Voth in Chicago. Here, I will characterize and quantitatively describe proteolytic cleavage of the CA/SP1 subdomain of the Gag-protein in HIV using quantum mechanical/molecular mechanical (QM/MM) Molecular Dynamics simulations (MD). Furthermore, I will employ free energy techniques to simulate binding and unbinding of the protease to CA/SP1 to determine the binding and configurational free energies. These processes are essential for HIV maturation and hence also targeted by drugs. Subsequently, I will parameterize Coarse-grained models for the Protease/CA/SP1 system and develop a Coarse-grained Green's Function Reaction Dynamics method. This method combines the Coarse-grained description with the mesoscopic scale, and hence allows me to simulate structural assembly of the virus capsid coupled to proteolytic cleavage at physiological conditions. This coherent computational approach targets biomolecular processes of outmost relevance, and will greatly advance our understanding, but likewise also push the boundaries of molecular simulations due to the methodological innovations. The third year will be spent in Trieste, in the group of Prof Bussi. In this period, I will develop a hybrid all-atom molecular mechanics / Coarse-grained (MM/CG) model for RNA. It facilitates the simulation of RNA fragments at atomistic resolution while capturing long-range allosteric interactions due to the Coarse-grained representation of the surrounding. This will set a new standard to simulate RNA macromolecules and offers a wide range of application.


**Keywords:** HIV, Proteolytic cleavage, Free energy simul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unfolding the Mechanism of Chromosome Cohesion and Condensation using Single-Molecule Biophysical Approaches' (Mechan-of-Chromo).

assistant: **Concept**

The global folding of the chromosome is mediated by Structural Maintenance of Chromosome (SMC) proteins, which stabilize the higher-order chromatin architecture by bringing distant DNA sequences together. Despite over a decade of work on these systems, their mechanism remains unknown, largely because of difficulty in re-capitulating physiological DNA binding and condensation in vitro. Moreover, traditional biochemical approaches are poorly suited for the study of processes that are fundamentally mechanical in nature. However, key breakthroughs, including the discovery that SMC is loaded by Spo0J protein at parS sites in vivo, and that parS sites act as global condensation centres for the chromosome have opened new possibilities to study chromosome organisation using single-molecule (SM) approaches. Importantly, our recent experiments with Magnetic Tweezers (MT) have already revealed a novel function of Spo0J in condensing DNA via a parS-independent binding mechanism.Inspired by these recent discoveries, I have devised a series of novel SM biophysical approaches with the ambitious goal of determining the mechanism of action of SMC complexes, including understanding the role of SMC loaders and SMC accessory subunits, and how these proteins are regulated by ATP binding and hydrolysis for chromosome organisation. The rationale behind this approach is that SM methods are particularly well-suited for monitoring DNA cohesion and condensation where manipulation of individual DNA molecules, measurement of forces, and addition of proteins and buffer solutions can be carefully controlled. High throughput MT will be combined with fast video imaging, optical trapping, and fluorescence; and will be used to interrogate hypothetical models for SMC-DNA interactions. Finally, the novel a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Encoded Cellular Synthesis of Unnatural Biopolymers' (ECSUB) under Seventh Framework.

assistant: **Objectives**

We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells. The orthogonal translation system has many potential applications beyond those possible with the natural translation system: I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficiency of in vivo unnatural amino acid mutagenesis via amber suppression, so that no truncated protein is produced and multi-site incorporation of unnatural amino acids is possible; 3) To create probes of protein function for use in vivo; 4) To free numerous codons for simultaneous encoding of multiple distinct unnatural monomers, and to experimentally explore alternate genetic codes; 5) To explore the evolution of encoded unnatural polymers toward new cellular functions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biomedical engineering as a means to improve quality of life' (BEAAMTIQOL).

assistant: **Innovation**

The Fifth EC Framework Programme has put forward a number of research priorities, to respond to real needs of European citizens and to enhance, amongst others, their quality of life. The European scientific community is invited to formulate research proposals to address these priorities and submit them to the expert panels of the EC.It is proposed here that ESEM (European Society for Engineering and Medicine), in collaboration with ESAO (European Society for Artificial Organs) would organise a scientific meeting to identify in detail how to respond to the demands of the 'Quality of Life' theme. The delegates attending the symposium will benefit from a reflection on which research projects can be proposed in the upcoming calls for proposals, based upon the actual state of the art in biomedical research and taken into account the research priorities of FP V. A report will be produced and disseminated broadly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pre-Commercial Production Demonstration of Very High Capacity Silicon Anode for High Performance and Low Cost Li-Ion Batteries'.

assistant: **Concept**

The global electric vehicle (EV) and Energy Storage Market growth depends highly on Li-ion battery levelized costs dropping 3/4 current costs by 2018. The most promising means to achieve 2/3 cost reduction is to improve battery density/capacity with the use of a silicon anode coupled with other advanced materials. Over the past 10 years an estimated $500m has been invested into developing silicon anode material, but it has yet to be industrially exploited.CLB Europe aim to offer the high-scale production of their proprietary Silicon-Graphene composite Anode Material, SiGrAM, designed for advanced Lithium-ion batteries. When used as the anode it is able to improve the batteries life cycle and charge/discharge characteristics by 300% while lowering overall cell costs by up to 70% (reducing size and weight).SiGrAM’s proprietary Chemical Vapour Deposition (CVD) manufacturing process uses carbon nano-platelets to uniformly embed silicon into graphene in stable structures, that in turn absorb the silicon expansion during battery charging. Such special nano-platelets create both strength and good elastic deformability that maintains its structural integrity for long cycle life.Results have shown the material to be the most stable silicon anode material known today able to triple the anode specific capacity. The material will be able to work in a variety of battery applications from consumer electronic devices to electric vehicles to utility energy storage systems.CLBE’s SiGrAM material is currently at TRL 6 as an early stage production process has proved positive. CLBE now requires funding to scale the production process for high demand and to validate further the product when coupled to other advanced cathode and electrolyte materials in Lithium-ion batteries, along with esta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Evaporative Cooling Technologies for dry and humid climates' (ECOOL) under Horizon 2020.

assistant: **Objectives**

Vitality Vector creates efficient applications of solid desiccants in thermodynamic processes. The main company focus is towards developing and commercialization of high-efficient desiccant based technology for a variety of HVAC and atmospheric water recovery applications. Vitality Vector has been recognized by the panel of experts (venture capital and industry insiders) at the global H2O challenge, which evaluates the innovation and uniqueness, sustainability and economic viability. As well as, the management team and the value propositionECOOL technologies comprise two novel (patent WO2015005791 A1) evaporative cooling systems: the RIDEC for dry climates and DEC for semi-humid and humid atmospheric conditions. The RIDEC and DEC systems can generate cooling energy as effective as than any commercial model of MVC, consuming 5-10 times less of electrical energy.The RIDEC (Regenerative indirect direct evaporative cooler) outperform traditional AC consuming 90% less electricity. Moreover, compared to existing regenerative cooling technologies, higher efficiency (20%) and a fraction of the cost, position the RIDEC at an advantage position in the path to displace inefficient vapor compressor technology. The DEC (Desiccant Evaporative Cooling) overcomes the humidity barrier for the applicability of evaporative cooling technologies. The DEC provides 70% energy savings in humid regions, that where reserved exclusively for vapor compressor technology.ECOOL covers the need to reduce energy costs, displaces consumption at peak demand and increases its cooling efficiency when outside temperature is high.  The expected market price of the RIDEC (50% less than equivalent AC unit) and DEC (similar price), on top of yearly energy savings, provide a winning value proposition. Vitallity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Few-Cycle Electric Field Waveforms for Advanced Science and Technology'.

assistant: **Innovation**

The aim is the development of a user friendly high power few cycle, phase stable, light source in the 1500-2000 nm wavelength range. This builds on technical feasibility demonstrated during the ASTEX Advanced Grant. To fully exploit the potential of this light source it is necessary now to optimize the following characteristics: peak power, the ultimate pulse duration, stability and convenience of use. We hope to do this by building on the work carried out in the ASTEX project, that demonstrated the principle of the generation and application of few cycle waveform stable 1800 nm pulses, by optimising the generation, power and convenience of use to enable many potential applications. It is the aim of this project therefore to develop this light source as a user friendly, stand-alone, optical device that can be located after a variety of commercial ultrafast OPA (Optical Parametric Amplifier) systems and so deliver few cycle 1500-2000 nm high power pulses directly to many and varied applications in technology and science. The applications are expected to have industrial/societal impact in Defence, Security, Analytical and Measurement Technology sectors. The hoped for outcome is a fully characterized prototype that can be developed into a commercial product. First steps in the latter direction will be taken during the project by linking with a suitable commercial partner after preparatory legal and IP protection actions are completed. The aim is a product that can be added on to a standard commercial OPA laser system to deliver state-of-the-art attosecond technology in an easy to use package.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Infant verbal Memory in Development: a window for understanding language constraints and brain plasticity from birth' in the context of a Horizon Europe call.

assistant: **Objectives**

Although infants perform more poorly than adults on many cognitive tasks, they are more competent language learners. Newborns must have access to an exceptional processing system where bits of the -inherently transient- speech signal remain encoded to build knowledge of the language around them. Memory, the ability to hold information in mind that is no longer present in the environment, is one of the most important components of this machinery. As yet, however, what characterizes the first cognitive and neural architectures of memory and if (and to what extent) these mechanisms constraint human language remain largely unexplained. IN-MIND proposes a fresh perspective that particularly emphasizes the study of verbal long-term and working memories as a journey in its development during infancy. The project aims to provide new insights into: i) how memories are formed at birth and sometimes stored for longer periods through the reorganization of neuronal circuits, ii) how infants’ verbal memory capacities and limits vary as their brain evolves in the first months of life, iii) when verbal working memory capacities emerge and whether they account for concurrent and later language outcomes, and iv) to what extent memory measured in the laboratory relates to how language is implemented in the real world. I will address these issues using an innovative and multimodal approach that combines experiments with behavioral techniques, wearable neuroimaging, polysomnography, and naturalistic recording in newborns, typically developing infants and infants at-risk for language impairments. The outcomes of this research may lay the foundation for identifying vulnerabilities in verbal memory capacities as well as the temporal windows in which eventual interventions might be more effecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable Algae Biorefinery for Agriculture aNd Aquaculture' under Horizon 2020.

assistant: **Concept**

SABANA aims at developing a large-scale integrated microalgae-based biorefinery for the production of biostimulants, biopesticides and feed additives, in addition to biofertilizers and aquafeed, using only marine water and nutrients from wastewaters (sewage, centrate and pig manure). The objective is to achieve a zero-waste process at a demonstration scales up to 5 ha sustainable both environmentally and economically. A Demonstration Centre of this biorefinery will be operated to demonstrate the technology, assess the operating characteristics of the system, evaluate environment impacts and collaborate with potential customers for use.The key advantages of SABANA project are: the sustainability of the process, using marine water and recovering nutrients from wastewaters while minimizing the energy consumption, and the socioeconomic benefits, due to the relevance of the target bioproducts for two major pillars in food production as agriculture and aquaculture. Bioproducts capable of increasing the yield of crops and fish production are highly demanded, whereas recovery of nutrients is a priority issue in the EU. Instead of considering wastewater as an inevitably useless and problematic residue of our society, SABANA acknowledges its potential as an opportunity for economically relevant sectors.SABANA project includes (i) the utilization of microalgae-bacteria consortia and in co-culture with other algae to control grazing species, (ii) the implementation of efficient thin-layer cascade and raceway, (iii) the scale-up of reactors to ensure stable operation, (iv) to use marine water to increase the sustainability of the process; (v) to recover nutrients from wastewaters, (vi) to develop harvesting processes taking into account the remaining water, (vii) to establish proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'aRTIFICIAL iNTELLIGENCE for the Deaf' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

aiD pursues cross-disciplinary breakthrough innovation that builds and extends upon the latest academic research advances. Its overarching goal is to offer a comprehensive suite of solutions catering to deaf people communication needs. aiD has the following objectives: 1) Create multi-modal, high-accuracy deep learning models for deaf/hearing people interactive communication. 2) Develop deep network compression techniques for scaling the developed models to mobile devices. 3) Implement application pilots of immense practical importance that will be evaluated by the end-users. 4) Promote global-scale excellence in science by supporting the Consortium partners to become leading experts in their field and transfer their acquired expertise to research institutions, companies and the public.  Our considered pilots deal with realistic operating environments that allow for end-user engagement and a solid exploitation plan: (i) an AR news service; (ii) an Automated Relay Service for emergencies; and (iii) an Interactive Digital Tutor application. We pursue technological development on multiple technological frontiers: signal processing, signal perception and generation via advanced ML, creation of virtual SL signals in an AR environment, and scalability of the developed technologies on commodity mobile devices, accessible to the vast majority of potential users. To achieve these objectives, aiD implements an inter-sectorial secondment program for Experienced Researchers (ERs) and Early Stage Researchers (ESRs) that fosters knowledge exchange between academic experts and industrial leaders in bleeding-edge technological fields. The social significance and bleeding-edge nature of our endeavors has resulted in the aiD consortium having already attracted the strong interest and com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Authoritarian Smart City' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The smart city fulfils a utopian picture of a future where data-driven, citizen-centred, and just cities thrive. What if this vision of the smart city is combined with the prospect of smart control? What about the sociotechnical imaginaries of authoritarian smart cities? Research on smart cities in authoritarian regimes, for example, in both Saudi Arabia and China, has rarely been critical and has almost never discussed this urban form as authoritarian or surveillant. Even when calls for a comparative global agenda have been issued, authoritarianism has not been a significant component. E-Authopia explores the formation of authoritarian smart cities through the interplay between global smart city trends and domestic policymaking in authoritarian contexts. Through three instrumental case studies of authoritarian smart cities in Turkey, Thailand, and Gabon, I will investigate how the smart city idea is appropriated and localised, how it is positioned within a political system, and how it is translated into governance initiatives. I use semiotic and discursive analysis to study the authoritarian sociotechnical imaginaries of desirable urban futures at the symbolic and language level. Additionally, policy process tracing will be conducted through global pathways of influence and multiple streams framework to illustrate how these imaginaries and visions are localised, concretised, and translated to agenda-setting in policy adoption and development.


**Keywords:** authoritarian surveillance, smart city, digital governance