RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protein degraders for targeting galectin-8' under Horizon Europe.

assistant: **Concept**

In the PROTAG-8 project, we aim to target galectin-8 by protein degradation using proteolysis targeting chimeras or shortly, PROTACs. Galectin-8 is a galactoside-binding lectin that exists as a soluble intracellular and extracellular receptor, with an extensive exchange between the membrane-bound and cytosolic forms. Its inhibitors are potential new anticancer drugs, but the affinity of classical galectin-8 inhibitors is in the low micromolar range, hardly sufficient for their use as drug molecules. The overarching aim of PROTAG-8 is to explore whether the PROTAC method can be implemented for galectin-8 and to answer the question of whether PROTACs offer advantages over classical selective galectin-8 ligands. Since PROTACs need only bind their targets with high selectivity and with an affinity high enough to stabilize the ternary complex between the protein of interest and the E3 ligase, the affinity in the micromolar range could be sufficient for their activity, unlike conventional ligands. The current state-of-the-art in the development of PROTACs focuses only on intracellular proteins, but galectin-8 exists as both an intracellular and extracellular protein. Based on this fact, we want to find out whether such a receptor, which occurs both in the cytosol and in the extracellular matrix, can be effectively targeted with PROTACS and its activity modulated. This scientific question will be tackled by a highly-qualified PhD Nives Hribernik with international experience in glycochemistry, medicinal chemistry and chemical biology, and is expected to be an excellent springboard to her independent scientific career. The project proposal includes renowned principal investigators from two academic institutions: Prof. Dr. Marko Anderluh from the University of Ljubljana (Sloveni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mobile Optical Clock with Neutral Atoms in a Blue Magical Optical Lattice' (2007-2013).

assistant: **Concept**

In today’s world, clocks play a very fundamental role in science and technology ranging from the Global Positioning System (GPS), international time standards to the test of the fundamental laws of physics at an unprecedented level of precision. In particular, millions of ultra cold neutral atoms confined in periodic light potentials can be used for precision metrology and quantum measurements. By carefully choosing the wavelength and polarization of the lattice laser, one can arrive at a situation where the two probed electronic states of an atom experience the same light shifts. In such a magical lattice, perturbations on the two electronic states due to light field cancel out and the spectroscopy becomes independent of the motion of the centre-of-mass of the atom. The main aim of this project is to create a novel mobile optical clock using Sr atoms in a “magic” blue detuned 3D optical lattice. The ultra narrow, 698 nm transition from 5s2 1S¬0 to 5s5p 3P¬0 is used as a clock transition. The clock, the first of its kind, has the fundamental limit at the level of 2×10-19 which is the minimum level of fractional uncertainty to date. In the first stage the project aims at a device to demonstrate relativistic geodesy and explore first applications. Furthermore this project will deliver enabling technology for various cold atom applications, such as force sensors for oil and mineral exploration or quantum simulation as a first step to full scale quantum information. These applications are now becoming mature with many fascinating laboratory demonstrations but suffer from a critical lack of readiness in terms of robust device-ready technology. This project aims at intra-European transfer of such technology from the German QUANTUS BEC in microgravity project to the UK and at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Isoform specific inhibition by transient protein state stabilization' (ISOTRAPSS) under Horizon 2020.

assistant: **Objectives**

The rapid identification of synthetic molecules that selectively inhibit some proteins among families of closely related proteins is one of the major unsolved problems of modern drug discovery. If such ability was at hand, it would radically revise our definition of the ‘druggable’ genome.     The goal of this proposal is to expand the state-of-the art of rational drug design with a new strategy that combines cutting edge computational techniques with modern experimental biophysical methods. We aim to achieve selective inhibition of proteins that are highly similar to other related proteins. To do so we will exploit concepts from energy landscape theory to identify transient conformational states of proteins that can be trapped by ligands to achieve extremely high binding selectivity.     To provide proof of concept for such strategy, we will focus efforts on the therapeutically relevant cyclophilin protein family. Computational work will focus on: 1) unravelling the conformational preferences of the most common cyclophilin family members, and 2) clarification of current controversies regarding the binding mode and structure activity relationships of known selective ligands. Experimental work will involve the characterization of purchased or custom-synthesized ligands in in vitro assays and crystal structure analyses.    Overall, this project proposes fundamental advances in rational drug design, therefore expanding opportunities for the development of future small molecule therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Laser Nanoscale Manufacturing' (LASERNAMI).

assistant: **Concept**

The project “Laser Nanoscale Manufacturing (LaserNaMi)” focuses on staff exchanging between the partners, especially between the partners of EU and China, on researching and developing new maskless laser nanoscale manufacturing technologies for low cost, simple and high speed manufacturing of nano structured surfaces and components including periodic structures (nano gratings, anti-counterfeiting security markers, nanoimprint templates, self-cleaning and antireflection surface nano-structures) and other arbitrary features.LaserNaMi has the following objectives : (1) To exchange ideas and technology concepts to further development on the new maskless laser nanoscale manufacturing technologies. (2) To complement fabrication and characterization technologies with other technologies of partners in the LaserNaMi consortium to produce nanostructures in thin-films. (3) To explore novel applications for the laser nanoscale manufacturing from the combination of the different backgrounds and disciplines of the partners of LaserNaMi. (4) To strengthen research partnerships through staff exchanges and networking activities between European research organisations and organisations from China. (5) To establish long-term research cooperation through the proposed coordinated joint programme of exchange of researchers for short periods during the project.LaserNaMi meets the objectives and requirements of the Marie Curie Action: International Research Staff Exchange Scheme (IRSES), and it will provide support to the consortium members to establish and reinforce long-term research cooperation in laser nanoscale manufacturing through a coordinated joint programme of exchange of researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Installation of a centralised facility for the provision of specialised heat shock protein reagents for a concerted investigation of the role of heat shock proteins in chronic diseases' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives: The establishment of a centralised facility for the provision of high-quality, standardised heat shock protein reagents, the reinforcement of the leading position of European scientists in the field and to open possibilities for development of new diagnostic and therapeutic measures. Once this CA facility becomes fully operative, it will be developed into a centralised facility, and make services/reagents available to scientists active in other European life science programmes.Brief description: Chronic inflammatory diseases, such as arthritis, are major contributors to the morbidity of European populations, justifying a European approach for studying these diseases of which several cause a considerable amount of suffering and high health costs for the societies.Studies carried out in a variety of distinct autoimmune (rheumatoid arthritis, ankylosing spondylitis, diabetes, lupus, multiple sclerosis, scleroderma, Behcet, juvenile chronic arthritis, Crohn's disease, billiary cirrhosis) and autoimmune-like (such as atherosclerosis, gastritis, transplant rejection etc.) diseases have shown that the occurence of disease coincided with the presence of immunity (both cellular [T cells] and antibody [B cells] mediated) directed against heat-shock proteins (hsp's, e.g. hsp60, 70's, 90). Thus it has been shown that immune responses to hsp's may be central to many of the chronic inflammatory diseases.In order to further understand pathogenic mechanisms and to enable development of future novel diagnostic and/or therapeutic possibilities, a concerted inventarisation of immunity to hsp's in chronic diseases seems now required. Many of the studies carried out so far have suffered from the lack of access to well defined high quality standardised hsp reagents. This has hind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Time dynamics and ContROl in naNOStructures for magnetic recording and energy applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The CRONOS project seeks to develop a quantitative, flexible and fully atomistic theory of ultrafast dynamics in real materials. Our effort will create the necessary knowledge for advancing two technological areas crucial for the economic future of Europe and the well being of its citizens: new materials for solar energy harvesting and ultra-high density magnetic data storage. In particular we will construct the necessary theoretical tools for addressing the problems of energy photo-conversion and laser-induced ultrafast magnetization dynamics. Crucially CRONOS will not just look at how an optical excitation perturbs a materials system but also at how such an excitation can be engineered to produce a desired response. Hence both the direct and the inverse problem will be tackled. CRONOS’ theoretical program will be validated by a broad experimental activity on ultra-fast pump-probe spectroscopy and by the presence in the consortium of European companies. Equally important is the fact that the consortium will produce a substantial amount of high-end scientific software, which will then be distributed freely to the academic community.The project will develop a quantitative and materials-specific theory for electron dynamics in nano-structures, which, at the same time, is fully atomistic, efficient, scalable to large systems, and rigorously theoretically formulated. The core of our method is time-dependent density functional theory, TDDFT, which was invented by a member of our consortium and has been developed over the years . Our workplan comprises formal methodological development, algorithm implementation, applications to both solar cells and magnetic recording, and experimental validation. A significant deliverable of this project will also be the wide distribution of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Facial Recognition Technologies. Etho-Assemblages and Alternative Futures' (2021-2027).

assistant: **Concept**

Facial recognition technologies collect billions of faces that are stored for multiple uses spanning individual identification and tracking, to training of deep neural networks, the mainstay of modern artificial intelligence (AI). From tagging a photo on social media or unlocking a computer, to controversial applications of facial recognition in public spaces, schools, workplaces, and law enforcement activities, facial processing technologies have entered almost every aspect of our lives. While expected benefits relate to security and safety, critics highlight that these technologies normalize surveillance and erode privacy, exacerbate discrimination, and contain insurmountable flaws and inaccuracy. The fAIces project asks: What matters in facial recognition technologies, and why? How politics of mattering enact diverse ways of being implicated? Which forms of citizenship and public engagement are affected? How multiple and complex ethical choices emerge?This study develops a novel methodology by which the perspectives of social groups that have never been studied together, which are jointly but antagonistically implicated in facial recognition technologies, are taken into consideration: scientists who conduct research on facial recognition; professionals working in start-ups and technology companies; members of advocacy groups and activists; black communities; and artists who incorporate facial recognition in their work. The fAIces project will produce an innovative social theory of the face through the combination of a new conceptual approach – “etho-assemblages”, which transgresses the idea of pre-given fixed and dichotomic ethical principles – and the generation of original empirical data. Major outcomes are based on expanding ethics and imagining alternative future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Innovative approach for self-management and social welfare of Cystic Fibrosis patients in Europe: development, validation and implementation of a telematics tool.'.

assistant: **Objectives**

Cystic Fibrosis (CF) is a genetic disease with the higher incidence in Europe showing c.a. 5% mortality in childhood. The majority of patients suffer from lifelong pancreatic insufficiency leading to maldigestion of food and malabsorption and consequently with malnutrition and growth stunting. An accurate enzyme replacement arises as an early nutritional intervention able to provide better nutritional status and patients’ welfare from early stages avoiding complications associated to the development of the disease. By means of our innovative and portable ICT tool we will improve the socio-economic impact of the disease, promoting healthy lifestyle, intertwining patient empowerment, education and training with self-management and prevention of secondary CF-complications. The multidisciplinary and complementary approach of this co-developed integrative PROJECT guarantees the patient’s adherence to the treatment and the best outcome of the nutritional intervention mainly in childhood. The beneficiaries of the application comprise patients, care-givers, families and health professionals as well as health monitoring authorities. MyCyFAPP is tailored designed and will be clinically validated for CF self-management and monitoring becoming a competitive market product in Europe. This APP will have a key role as decision support system, boosting the growth and competitiveness of the participating SMEs in Europe which will ensure the commercial exploitation of the results, the market uptake and the MyCyFAPP distribution for the benefit of the patient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EELISA INNOvation and COmmon REsearch strategy' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The European Engineering Learning Innovation and Science Alliance (EELISA) is a bottom-up alliance of higher education institutions representing more than 180,000 students and 50,000 graduates each year, 16,000 faculty members and 11,000 administrative staff. EELISA is one of the European Universities selected by the European Commission under an Erasmus+ call. With EELISA we are initiating an unprecedented level of institutionalised cooperation between our institutions in order to gradually achieve our long-term vision: the education of European Engineers. Now we see an opportunity to transform our R&I dimension with EELISA INNOCORE. Our plan is built on the ecosystem of EELISA communities created to transform higher education, and comprises three main steps: 1) Make our researchers and innovators know each other, create spaces for dialogue with citizens and with non-academic actors and set up a portfolio of shared scientific infrastructures; 2) foster and support the development of joint R&I actions and the creation of new structures (research groups, clusters, joint labs, start-ups, scientific parks) and  3) optimize the outreach of these actions. In parallel, we work on a common strategy on open Science, we assess the costs and benefits of actions and deploy plans to promote gender equality, diversity and citizen science.


**Keywords:** European University, Research, Innovation, Open Science, Citizen Science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Augmented Reality Enriched Situation awareness for Border security' (ARESIBO).

assistant: **Innovation**

ARESIBO aims at improving the efficiency of the border surveillance systems by providing the operational teams and the tactical command and control level with an accurate and comprehensive information. The pillars of research in ARESIBO are three-fold: 1. Set-up a complete configuration at tactical and execution level to optimise the collaboration between human and sensors (fixed and mobile), 2. Improve situation awareness by enhancing the understanding of the situation through adapted processing of sensor data, correlation between heterogeneous data and information and creation of knowledge through deep learning techniques and 3. Create a situation awareness capability at C2 level that will combine reports on previous missions, real time situation understanding and threat analysis for future actions. This capability will be used to optimise the operations (teams deployment and sensor positioning) as well as an online briefing tool for the teams that will be able to access to the results of the previous missions while in the field. ARESIBO integrates research activities in the domain of 1. surveillance platforms (air, ground, surface, underwater) to optimise the collaborative capabilities of the platforms and their positioning (between themselves and with the teams), 2. Sensor processing to interpret, fuse and correlate all the data to produce information and knowledge and 3. Augmented reality techniques to elaborate and provide to the operators a situation awareness picture which is fit for their missions (minimum information for maximal understanding) both as team level and tactical C2 level. The ARESIBO system will be developed incrementally during the 3 years with two major versions that will lead to sub-versions for land and maritime borders. The system will be tes