RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Territorial RRI fostering Innovative Climate Action' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TeRRIFICA – Territorial RRI Fostering Innovative Climate Action – will create a comprehensive overview on the state of the art of climate change adaptation research, tangible climate action and climate change adaptation examples, related policies as well as communication strategies and methods at different levels of complexity. Through its co-creative multi-stakeholder approaches the project will identify opportunities, drivers and barriers of implementation. It takes into account challenges for the acceptance and feasibility, technological and regulatory constraints in six pilot regions in Spain, Germany, France, Serbia, Poland and Belarus.  The selected pilot regions cover the diversity of climate change mitigation approaches in Central– South, East – West, urban – rural, EU – non-EU settings. The project will define and adapt innovative communication strategies, dialogue actions and formats. Through Living Lab methodologies, different stakeholder-groups (with a particular focus on regional authorities and policy makers) will be integrated as co-creating and actively participating partners. This will lead to recommendations, procedures, tools and methodologies that are appropriate to the different roles and objectives of these parties and which will consider the key policies of RRI and integrate Sustainable Development Goals.  TeRRIFICA will set up tailored roadmaps and key performance indicators for the implementation of developed methodologies and climate change adaptation activities in regional practice. Customised capacity building for the different stakeholder groups will be offered. Field trips to local and regional promising activities related to research and regional innovation, and broader stakeholder engagement with feedback loops will be organised to learn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Transitivity in Courtroom Language: A Unified Solution' under Horizon 2020.

assistant: **Concept**

TICLAUS denotes a research proposal in which four areas are combined, namely Critical Discourse Analysis (CDA), Corpus Linguistics (CL), Forensic Linguistics (FL) and Systemic Functional Linguistics (SFL). The reason for doing so is that the aim here is twofold. On the one hand, TICLAUS strives to make theoretical advances within the field of SFL, through applying CDA and CL methods to analyse language and, thus, improve upon the two transitivity systems currently in use in linguistics. On the other hand, using a revised and enhanced transitivity model, TICLAUS also intends to reveal how a transitivity analysis of language use inside the courtroom and/or through informal interviews with rape victims and individuals who have been wrongfully imprisoned for rape, can provide invaluable insights into how two types of victim represent their experience of victimhood. Given the dearth of transitivity research in FL, in addition to a complete lack of studies that examine wrongful convictions, TICLAUS is clearly innovative. The methodology used in this project is better known as Critical Assisted Discourse Studies (CADS), which consists of a combination of CDA and CL procedures, thus enabling both a quantitative and in-depth qualitative analysis of a large dataset. TICLAUS is considered a high quality proposal as a result of the commitment of all those involved as well as the support from three separate institutions worldwide, all of which are leading universities in their country and further afield. Furthermore, the interdisciplinary nature of this proposal is nurtured by the fact that both supervisors, Professor Taboada and Professor Hidalgo Tenorio, are experts in CDA, CL and SFL whilst the ER, Dr Bartley, is able to contribute her expertise in transitivity and FL.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploring the link between innate Immunity and cellular Aging' (ImAgine).

assistant: **Concept**

The innate immune system has evolved signalling receptors, which detect various stresses including microbial infection but also signals emanating from non-infectious cellular damage. Upon activation, these signalling receptors can trigger a variety of distinct effector responses collectively aimed towards maintaining the integrity of the host. The recognition of cytosolic DNA through the cGAS-STING pathway is a fundamental mechanism through which pathogens and cellular stress evoke an inflammatory response. Recently, we discovered a new role of the cGAS-STING pathway in promoting cellular senescence, a critical stress response program that is emerging as a key driver of aging. On the basis of this finding, the overarching gaol of ImAgine is to further explore the molecular links that exist between the mechanisms of innate immune signalling and those underlying aging processes. Specifically, we will address whether the cGAS-STING pathway acts as a contributor to age-associated phenotypes and we will interrogate mitotic perturbations as a physiological source of age-associated damage that activates the innate DNA sensing machinery. Another intriguing possibility emerging from our work is that cellular senescence is relevant for the host response against pathogens. Utilising an array of genetic and pharmacological tools, we will challenge this idea and molecularly decipher the role of senescent cells in physiological models of acute and chronic infection. A detailed picture of the interplay between innate immune pathways and cellular ageing will not only be a critical step towards a global understanding of fundamental host response mechanisms, but may also provide new concepts for the treatment of diseases that are associated with infectious diseases or ageing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microfluidic Advanced Manufacturing of Ultrasound Contrast Agents' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Tide Microfluidics is developing a patented technology capable of increasing the diagnostic capability of ultrasound. We have an advanced microfluidic manufacturing technique for producing ultrasound contrast agents (UCA) of controlled size to enable 20 times clearer images. Our uniform UCA’s are unique, as current UCA’s are composed of wide size distribution microbubbles, making them less effective. We aim to develop our technology into a bedside production device, which would lead to a reduction in diagnostic imaging costs, as ultrasound is cheaper than MRI or CT, and gives better images for faster and more accurate diagnoses. We would use Phase 1 funding to commercially and technically assess the feasibility of our device. We need to understand the users requirements and how best to fit into their workflow, as well as how to create a robust, reliable and user-friendly design. Economic viability will be studied, as pricing must be cost effective or market uptake will not occur. Finally, we will investigate the clinical validation needs and level of medical certification required for our bedside production device to be accepted in Europe, the USA and the rest of the world. This knowledge on feasibility, cost pricing and validation defined in Phase 1 would work as a roadmap for our development during a Phase 2 project. Thus, exploitation of SME instrument Phases 1 and 2 would secure the continuous development and validation of our device allowing for a rapid market entry, bringing a valuable tool to the end users and reducing healthcare costs. We aim to enter the ultrasound imaging market with our bedside device. Currently, more than 3 million ultrasound procedures using UCA‘s are carried out each year worldwide, with the European market alone worth $46 million. Ultimat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical validation of a continuous flow peritoneal dialysis system, with dialysate regeneration' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Goal is the clinical validation of a new peritoneal dialysis (PD) system called CORDIAL. Instead of a stagnant filling as in traditional PD, CORDIAL continuously circulates and regenerates dialysate in the peritoneal cavity. Hereby, a significant improvement in blood purification (2-3x) can be achieved in comparison to traditional PD. For the regeneration, a sorbent unit is used to remove toxins from the peritoneal dialysate by adsorption. The sorbent system also facilitates slow release of glucose needed for osmotic removal of excess fluid (i.e. ultrafiltration). Very high glucose concentrations, as used in traditional PD and harmful to the peritoneal membrane, are no longer required, which helps to preserve the membrane function. CORDIAL is an easy to use, portable/wearable machine that allows renal patients to dialyze conveniently at home or at work, independently from a fixed water supply, up to 24 h/day. With the improved clearance and low glucose load, CORDIAL eliminates current drawbacks of PD (low efficacy, high glucose concentrations leading to damage to the peritoneal membrane), benefiting the overall health condition and quality of life (fitness, lower pill burden). In order to demonstrate clinical efficacy and safety of the system an early feasibility first-in-human (FIH) trial will be performed in PD patients. The FIH study will involve a group of 12 stable PD patients who will be treated for 6 days with the new PD system spread over two weeks (3 consecutive days per week), which will be compared with baseline measurements in the week prior and after CORDIAL treatment. In addition, an advanced computational model will be developed and validated for CORDIAL using the FIH data, which can be used to conduct virtual human trials for rapid optimization of device
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Re-emerging Magic Molecules: The Medicalization of Psychedelics in the United States' in the context of a Horizon 2020 call.

assistant: **Objectives**

This proposal presents a research-via-training project that will transfer knowledge from the U.S. to Europe and allow the experienced researcher to deepen her study of (re-)emerging scientific fields to advance her career significantly. The project explores how scientists and other actors currently re-frame psychedelics in a scientific model to make them into licensed medicines. Since their introduction into Western science and culture (1930s-60s), psychedelic substances such as psilocybin or LSD have been highly controversial. Although early research indicated promising psychiatric applications, Western governments began to see psychedelics as a threat to public health in the 1960s and placed them into the most restrictive drug category, ascribing them a high potential for abuse and no currently accepted medical use. After coming to an almost complete standstill for several decades, psychedelic research is slowly re-emerging since 2000, highlighting again their potential for treating mental health issues such as addiction, depression, or PTSD. Since neither the molecules nor regulations have changed, this project investigates which socio-political conditions have enabled this revival (e.g., changes in the scientific or broader culture, risk-benefit evaluations). It traces how the responsible re-integration of psychedelics is fostered through the interplay of actor constellations, the production of scientific knowledge, and sociotechnical imaginaries. Using a qualitative research methodology and approaches from Science and Technology Studies (STS), it focuses on three molecules that are at the center of contemporary research in the U.S. (the country currently at the forefront of psychedelic research): MDMA, psilocybin, and ketamine. The project results will yield import
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Compressed Sensing for Remote Imaging in Aerial and Terrestrial Surveillance' (CS-ORION).

assistant: **Concept**

In this project, our focus is on the design, testing, and evaluation of compressive sensing (CS) architectures for enhancing the high-quality video acquisition and delivery capabilities of remote sensing devices that will enable them to provide efficient remote imaging in aerial and terrestrial surveillance. We will address limitations to current video coding methods which restrict the use of remote sensing devices to offering only a low-quality streaming video to the user. In order to overcome these limitations, novel algorithms which go well beyond the currently developed techniques and standards are needed. Equally importantly, the proposed methods must be developed with the hardware constraints of the platform of operation in mind, including restrictions regarding computational, memory, and power consumption, as well as the available reserved bandwidth. The proposed activities are designed in order to address these challenges. An important aspect of this project is the conscious exploitation of the inherent encryption of the signal that the compressive sensing methodology offers. We intend to use this property to enrich the signal intelligence capabilities of surveillance systems. The proposed consortium consists of partners with complementary expertise which covers all the involved research areas, from the point of capturing the video imaging content to the point that it is dynamically reconstructed and analyzed through CS reconstruction techniques by the user.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Decomposition methods for discrete problems' (BOBR).

assistant: **Concept**

The main goal of the project is to radically expand our understanding of decomposition methods for discrete problems, with a particular focus on the design of parameterized and approximation algorithms on graphs. We will concentrate on four topics where we see a potential for either establishing new directions, or reaching far beyond the current state of the art.    (Beyond) Sparsity: The field of Sparsity is a rapidly developing area of graph theory that studies abstract notions of uniform sparseness in graphs and provides a wealth of tools for algorithm design. While there are still many unknowns within this field, we would like to reach beyond sparse graphs by developing a theory of well-structured dense graphs, inspired by the advances in Sparsity.    Parameterized dynamic algorithms: The idea of parameterization has so far received little attention in the field of dynamic algorithms. Our goal is to establish solid foundations for the direction of parameterized dynamic algorithms by providing dynamic variants of basic decomposition tools used in parameterized complexity.     Parameterization and approximation on planar graphs: The areas of parameterized algorithms and of approximation schemes on planar graphs share a core set of decomposition techniques and benefit from extensive cross-inspiration. We will approach several intriguing questions in this area while focusing on the idea of parameterized approximation schemes, where parameterization and approximation is explicitly combined.     Forbidding induced subgraphs: Structural graph theory offers a wealth of tools for understanding structure in graph classes characterized by forbidding induced subgraphs. This structure, while elusive and difficult to exploit, often leads to surprising tractability results. Motiva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Harnessing Ostwald Ripening for Dynamic Emulsions'.

assistant: **Concept**

Controlling the exchange of material between organs, cells and organelles is essential for all of the processes essential to life, such as signalling, metabolism and reproduction. Chemicals pass between compartments by diffusion, which is often assisted or rectified by biological machinery. A central goal of Systems Chemistry is to produce networks of discrete synthetic compartments that interact with the same complexity seen in life. Key to achieving this is the ability to control and regulate diffusion. The HORDE programme will harness Ostwald ripening as a tool that will enable controlled diffusion within emulsions. Ostwald ripening is the net directional diffusion of molecules from less to more stable states. In emulsions, this results in a spontaneous increase of average droplet size. This is thermodynamically favourable as it reduces the disfavoured liquid-liquid interface area. Ostwald ripening is generally seen as an unwanted process as it can lead to emulsion deterioration. However, when controlled, it will prove a powerful method for directing diffusion between compartments. HORDE will address this gap of knowledge by developing the novel methodology and insight that enables Ostwald ripening to be toggled and reversed. We will apply dynamic chemistries, switchable costabilisers and reversible polymerisation to control nanoemulsions.I will apply my unique expertise that spans supramolecular chemistry and polymer nanotechnology to develop nanoemulsions with droplets that shrink or grow on demand. We will then apply this technology to generate nonequilibrium states and direct the transfer of polymer sequence information between droplets. The HORDE programme will thus demonstrate the exceptional promise of controlled Ostwald ripening as a mechanism for developing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of mechanisms underling the balance between inflammatory and regulatory immune response in Multiple Sclerosis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Multiple sclerosis (MS) is an autoimmune disease whose pathology is directly mediated by inflammatory autoimmune T cells. The mechanisms determining the initiation of inflammation by T cells are still unknown. Since antigen presenting cells (APC) play a crucial role in the activation of T cells, their involvement in directing the quality of T cell responses in MS is likely. Thelper (Th) 17 type of immune response is responsible for mediating pathogenesis during autoimmunity. In contrast, Tregulatory (Treg) cells suppress the functions of effector T cells, thereby protecting tissues from the devastating damage inflicted by non-specific inflammation. A delicate balance of soluble factors is involved in the differentiation of naïve T cells into either polarized inflammatory Th17 or suppressive Treg cells. Moreover, the increase of Th17/Treg ratio in MS patients suggests a functional antagonism between Th17 and Treg cells, and a dichotomy in their generation as well. In this project we aim to characterize the involvement of APC in the Th17/Treg balance during MS disease. We will purify primary APC subsets and we will stimulate them ex vivo with Toll like receptor (TLR) agonists. A specific transcriptional profile of APC purified from MS patients versus healthy donors will permit to select genes differentially expressed and potentially involved in the activation of T cells. In order to clarify the role of selected APC molecules, we will block them before coculture APC with naïve/memory T cells. Differentiation of T cells will be analysed through the measurement of Th17- and Treg-specific features and in vitro functional assays. These results will clarify whether the signals originating from APC in MS patients underlie the Th17/Treg imbalance. Moreover, the characterization o