RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hack your Diabetes Experience' (SocialDiabetes).

assistant: **Innovation**

The direct annual cost of diabetes is more than €736 billion, with 15% accounting for antidiabetic drugs, 24% for other pharmaceutical compounds and 61% for primary care and hospitalisations. But the social impact is also huge, with 51% of patients experimenting emotional anxiety, 17% having depression episodes and 19% feeling discriminated because of the condition. Control of glucose in blood (combining diet, physical activity and medication if necessary), control of blood pressure and lipids, and regular screening for damage to the eyes, kidneys and feet, are cost-effective interventions in diabetes management. 1% reduction of HbA1c levels reduces heart attacks by 14%, microvascular complications by 37% and diabetes-related deaths by 21%.SocialDiabetes is a mHealth solution that can reduce HbA1c levels to normal values (6.4%) in 6 months of continuous use. It is based in a set of proprietary algorithms integrated in a mobile application and a web platform where patients can log data (glucose measurements, food intake, insulin administration, exercise) and doctors can monitor the disease. The app also calculates insulin doses, which is a unique feature compared to similar apps, and offers integration with glucose meters from major providers. Currently the solution is being exploited through a B2C model, with a free and a premium subscription plans.The aim of the project is to implement a B2B model catching the attention of major healthcare providers and stakeholders (public and private hospitals, governments, insurers) so they would adopt SocialDiabetes as the standard tool for disease management. The business opportunity lies in the benefits for the health of patients and ultimately in the reduction of costs for the whole system. Product and business development strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Supporting the EOSC Partnership in further consolidating the coordination and sustainability of the EOSC ecosystem' in the context of a Horizon Europe call.

assistant: **Objectives**

EOSC Gravity will support the transition of the European co-programmed Partnership for EOSC into its new governance and funding framework. EOSC Gravity will leverage EOSC Focus engagement channels and facilities and establish new ones. Through open calls, EOSC Gravity will provide funding to support the EOSC Federation by encouraging the creation of EOSC Nodes, inter-project collaboration, and will support the revision of SRIA 2.0. The further evolution of the EOSC Federation will be charted through measures to monitor and report on EOSC Partnership KPIs and to establish a methodology to assess the impact of EOSC. What: EOSC Gravity will support the Partnership in its role of charting a continuous flow of up-to-date and accurate information on the status of EOSC and developing strategic recommendations through the SRIA to ensure that the Partnership transitions into a new governance and funding model post-2027.HOW: EOSC Gravity will mobilise and grow the broader EOSC community with outreach and engagement activities empowering stakeholders to further evolve the EOSC Federation; and will directly fund actions to support the creation of several EOSC Nodes. The EOSC Academy will be anchored to ensure an informed community has the expertise to foster EOSC-related activities at country and institution levels. Projects will collaborate and will feed their results into EOSC-A Task Forces. WHY: EOSC Gravity will pull the EOSC communities of stakeholders together to contribute to a smooth and effective transition from the Partnership to a new governance and funding framework for EOSC post-2027. Multi-stakeholder collaboration and dialogue which builds on EU and national investments in this area is needed for the future of EOSC as a federated infrastructure.WHO: The EOSC Gravity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The genetics of enduring isolation: diversity, gene flow and offspring performance in glacial relict tree populations' (RELICTOAK) under Seventh Framework.

assistant: **Objectives**

The response of species to changing environments is likely to be determined largely by population responses at range margins. In contrast to the expanding edge, the low-latitude limit of species ranges remains understudied, and the critical importance of its populations as long-term stores of species’ genetic diversity and foci of speciation has been little acknowledged. Here we propose to study a set of 23 low-latitude marginal populations of the widespread European forest tree Quercus robur (Pedunculate oak) in central Spain in order to elucidate how these were able to sustain their genetic diversity and viability through multiple glacial cycles. For this purpose, we investigate how genetic diversity is distributed and transmitted across populations. Because gene dispersal plays a central role in this process, we examine patters of historical and contemporary gene flow involving three levels: within populations, among populations, and between species. Finally, germination and growth experiments under controlled conditions will be used to assess whether low levels of genetic variation actually result in reduced fitness and resistance to abiotic stress. This study should help improve our understanding of how glacial relict populations manage to persist under adverse conditions and provide valuable background information for developing appropriate strategies for their conservation and management in a changing climate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Maternal temperature history controls progeny vigour'.

assistant: **Objectives**

It has long been known that mother plants have a significant influence on progeny traits such as dormancy, seed size, and seedling growth vigour. Temperature is a highly influential environment factor on seeds, and can be sensed directly by either the mother plant or by developing seeds themselves, using an unknown mechanism to integrate temperature information over time. The endosperm plays an important role in the temperature regulation of dormancy, but and previously direct investigation of temperature-controlled events in the endosperm has been limited by the small seed size of the model species Arabidopsis. Here, I will investigate how temperature controls progeny dormancy and seedling growth vigour via endosperm in Brassica oleracea, a key vegetable species that contributes to human health and nutrition, using high resolution timeseries transcriptomics. Gene network and epigenetic profiles will be analysed dynamically and integrated for endosperm and embryo at different after temperature perturbations, to form a high resolution of early and late events that lead to temperature signals in seeds. This will enable the identification of key genes and stably-inherited epigenetic markers involved in temperature-induced differences in seed vigour difference. The resulting model will be tested in Arabidopsis and Brassica by knock-out mutant and transgenic experiments. This duel approach is an effective strategy to control risk. Avenues for the effective dissemination and exploitation of results will be developed by the fellow. Relevant training will be provided to during the fellowship. Ultimately, this project enable us to better understand seed vigour and could benefit seed companies, farmers and policy-makers by showing how to add resilience to environmental variation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Security in transition: An Interdisciplinary Investigation into the Security gap' (SIT-SG).

assistant: **Concept**

The twentieth century model of security, based on the rule of law and policing within nation-states and conventional military forces externally is no longer easily applicable to twenty first century global security risks. The security gap refers to the fact that millions of people live in situations of intolerable insecurity as a consequence of armed conflict, organised crime, terrorism, financial crisis, poverty and inequality, environmental degradation, vulnerability to natural disasters to name but some of these risks and yet current public security provision is not designed to address these sources of insecurity and, indeed, as recent wars in Iraq and Afghanistan have shown, sometimes makes them worse.Security in transition’ is about investigating and identifying the nature of the security gap and tracking the ways in which public and private agents are adapting. It has five components: narratives; indicators; rules; tools; and geographies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards evidence-based combinations of approved and novel cancer drugs' to be submitted under Horizon 2020.

assistant: **Abstract**

Background: Molecular targeted therapy (TT; e.g., monoclonal antibodies, mAbs, and protein kinase inhibitors, PKIs) intercepts oncogene and other addictions of tumours. However, unlike chemotherapy, which employs cocktails of drugs, only rarely does TT harness poly-pharmacology. Because lung cancer is the major cause of oncology related fatalities and many driver mutations are known, this disease offers opportunities for establishing and generalizing novel TT combinations and their interface with the immune system. Working hypothesis: High granularity maps of compensatory loops evoked by TT, along with deeper understanding of mechanisms underlying drug action, resistance and interactions with lymphoid/myeloid cells, will conceptualize drug combinations able to persistently inhibit tumours, while inducing only limited toxicities.Goal and specific aims: Addressing resistance to TT, potential synergies and the immune system, we will employ lung cancer models driven by mutant EGFR, HER2, MET or AXL. Phosphoproteomics, transcriptomics and RNA interference, will enable mapping adaptations evoked by specific drugs. Once identified, we will test combinations of interceptors able to inhibit the primary target as well as the emerging, resistance-conferring route(s). Next, we will determine the mechanisms of action of selected interceptors (e.g., apoptosis, immunological cytotoxicity and senescence) as bases for optimising effective combinations. Homo-combinations of antibodies (i.e., antibodies recognising distinct epitopes of a receptor), hetero-combinations targeting distinct signalling and immune receptors, and combinations with PKIs will be examined in animal models.Significance: More than 30 PKIs and >25 mAbs are approved in oncology, but most are used as monotherapies. Deta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PIWI-interacting RNAs at the interface of virus-host conflicts in Aedes aegypti mosquitoes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Background: The mosquito Aedes aegypti transmits viruses with pandemic potential but is also host to a large repertoire of mosquito-specific viruses and endogenous retroviruses. These viruses may invade the ovaries and eventually the oocyte to be transmitted from mother to offspring and to expand in the population. This transmission route exposes them to the specific host defense mechanisms of the ovary, which they must overcome to ensure onward transmission. This intriguing virus–host conflict is crucial for virus evolution and ecology and for host reproduction and survival, but has thus far not been studied. Hypothesis: I hypothesize that a specific class of small RNAs, called PIWI-interacting RNAs (piRNAs), are essential for protection of the mosquito germline from virus infection.Aim: My goal is to define the role of the piRNA pathway as a host defense system against RNA viruses, endogenous retroviruses, and other genomic parasites, and to identify viral counter-defense mechanisms. Additional to these fundamental aims, we will reprogram the piRNA pathway to induce resistance against pathogenic viruses in mosquitoes. Approach: This interdisciplinary project c¬ombines powerful genetic, genomic, and proteomic approaches at the intersection of virology, RNA biology, and entomology. Of particular importance, we will establish urgently needed tools for tissue-specific gene inactivation in vivo to define the functions of the expanded PIWI gene family of mosquitoes.Importance and Innovation: ERC project PIWIdefense will be the first to define host defense functions of the piRNA pathway in the germline of a major vector mosquito. The project generates unprecedented insights into the fundamental processes that shape the fascinating virus–host conflicts in mosquitoes. In addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Portable solution for prehospital diagnosis of stroke  in the ultra-acute phase'.

assistant: **Objectives**

This project will change the clinical landscape for the early and differential diagnosis of stroke – moving the diagnosis to the primary ambulance intervention site with the use of Strokefinder – an innovative medical diagnostic device based on microwave technology. Today, stroke is responsible for 405,000 deaths (9%) in men and 583,000 (13%) deaths in women each year. The projections indicate that between 2015 and 2035, overall there will be a 34% increase in total number of stroke events in the EU. Most strokes (87%) are ischaemic (caused by thrombosis or embolisms) and the rest (13%) are haemorrhagic (caused mainly by rupture of blood vessel or aneurysm). The complications of ischaemic strokes may be limited by early thrombolytic therapy (treatment to dissolve blood clots). However, while 20-30% of patients arriving at specialised stroke centres may receive thrombolytic therapy, only 3-4% of the patient population are given such treatment, mainly due to long lead times in transport to and from the diagnostic instruments (CT-scans). A haemorrhagic stroke (bleeding) excludes thrombolysis therapy until a proper diagnosis is performed. Medfield Diagnostics has developed a portable, more affordable and easy-to- use diagnostic device for this clinical dilemma. The device utilizes changes in the electromagnetic properties of the brain as a biomarker to exclude haemorrhagic stroke. After having provided proof-of- principle in smaller clinical trials and developed a robust prototype, the objective of the proposed project is to develop a business plan that will guide a large-scale prospective clinical trial to validate the device and optimize the go-to-market strategy. The goal is to make early stroke diagnostic and more effective personalized treatment accessible to a much wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Smart wavy patterned implants with instructive properties for tissue regeneration by controlling the degree of fibers buckling.' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

In the pursuit for engineering CELL HYBRIDGE regenerative medicine implants able to regenerate skeletal tissues by controlling adult stem cell activity, we have developed an innovative method to successfully improve cell migration into electrospun scaffolds. Whereas this has a direct impact in CELL HYBRIDGE as part of the planned activities, we unexpectedly discovered that the same scaffolds display wavy patterns that have a direct influence on cell differentiation by enhancing their intrinsic capacity to produce growth factors. Driven by these observations, we have optimized the methodology and are able today to control the formation of such wavy patterns at a single fiber as well as multiple fiber scales by controlling the degree of buckling that the fibers are exposed to during processing. In doing so, we can reproduce the same waviness that is observed in several native tissues, among which tendons and ligaments. The aim of BUCKLING BRIDGES is to further investigate these instructive scaffolds as potentially smart implants for the regeneration of anterior cruciate ligaments. This will be done by further confirming our in vitro data and proof our concept by showing successful ligament regeneration in a preclinical animal model. While doing so, we will also explore the market potential of such products and develop a business plan for the creation of a spin-off company: TISSUE BRICKS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Refsum's disease: diagnosis, pathology and treatment (RDDPT)' (RDDPT) targeting Fifth Framework.

assistant: **Abstract**

The pyramid acid storage disorders represent a diverse group of inherited neurological disorders with adult Refuses disease as the prototype. Although the age of onset and disease severity may differ, most patients show progressive neurological deteriorations and retentions pimentos culminating into blindness. It is the aim of this project to perform a detailed and comprehensive study on the diagnosis, incidence, pathology, variability of phenotypic presentation, and treatment of Refuses disease and related pyramid acid storage disorders. Bringing together complementary levels of expertise in the form of a multidisciplinary taskforce will do this. Rapid dissemination of information gained during the course of the project will be achieved through a publicly available website.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rapid, robust & scaleable platform technology for fully automated reference laboratory grade Polymerase Chain Reaction (PCR) based diagnostics regardless of global setting' in the context of a Seventh Framework call.

assistant: **Objectives**

RANGER addresses the HEALTH-2007-2.3.3-4: Innovative point-of-care (POC) diagnostic tests for influenza call by providing a innovative solution to the immediate need for a rapid, robust, cost effective & user friendly POC diagnostic for influenza.  We will develop the following real-time PCR system: 1)  A robust, portable system allowing testing at the POC anywhere in the world  2)  Raw sample to result automation of the entire test process including sample preparation  3)  Parallel processing of multiple samples & different sample types (aspirates & swabs) in a modular, user-friendly system 4)  RAPID & simple positive/negative result to the end user 5)  No need for an external computer or laboratory equipment  6)  Low cost consumable & reagents with a target cost of < €10 per test 7)  Sample preparation & freeze dried reagents pre-packaged into an ambient stable consumable to eliminate cold storage chains 8)  High confidence PCR results providing sensitivity & specificity equivalent to reference laboratory assays    a. Suitable for the diagnosis of early stage infections where viral titres can be low    b. Applicable to late surveillance & can be used to confirm the results from lower cost, low performance screen tests such as antibody assays that have low sensitivity and specificity.     c. Simultaneous identification of specific influenza strains & viral subtypes using multiplexing real-time PCR assays will also allow exclusion of related respiratory diseases 9)  Surveillance Management software & geographical data using GPS, allowing health authorities to manage early stage epidemics. The RANGER consortium includes WHO reference sites for human influenza diagnostics & world leading companies to develop and validate a POC influenza diagnostic system within 2 years. T