RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting the transcriptional mechanisms controlling growth during normal development and cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main scientific questions addressed in this proposal relate to the understanding of molecular mechanisms of growth control and cancer through the combined use of high-throughput technologies and computational biology. We aim to create a systems-level understanding of the cell cycle, and its regulation by physiological growth factors and oncogenes through the use high-throughput biology to identify all or the majority of genes that are essential for cell cycle progression, and by combining this dataset with computationally predicted and experimentally validated target genes of growth factors and oncogenic pathways. In my opinion, such systems biology approach is critical for understanding of growth control, as organ-specific growth control has proven particularly refractory to genetic dissection. Much of what we know about physiological mechanisms controlling cellular growth in mammals has been revealed by human cancer genetics. These studies have revealed that a large number of genes can contribute to aberrant cell growth; there are more than 300 genes that have been linked to cancer, and mutations found in cancer are often cell type specific ( oncogene preference , i.e. PTCH mutations in medulloblastoma, APC in colon cancer, TMPRSS2-ERG in prostate cancer), suggesting that different pathways in different cell lineages are coupled to the cell cycle machinery. We have preliminary evidence that hedgehog (Hh) and Wnt signals are directly coupled to expression of N-myc and c-Myc genes, but only in tissues and cell-types that display a proliferative response to these factors. Both classical molecular and developmental biology as well as high throughput and systems biological methods will be used for dissection of the molecular mechanism of this selectivity. If successful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Josephson Junction Spectroscopy of Mesoscopic Systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Spectroscopy is a powerful tool to probe matter.  By measuring the spectrum of elementary excitations, one reveals the symmetries and interactions inherent in a physical system.  Mesoscopic devices, which preserve quantum coherence over lengths larger than the atomic scale, offer a unique possibility to both engineer and investigate excitations at the single quanta level.  Unfortunately, conventional spectroscopy techniques are inadequate for coupling radiation to mesoscopic systems and detecting their small absorption signals.  I propose an on-chip, Josephson-junction based spectrometer which surpasses state-of-the-art instruments and is ideally suited for probing elementary excitations in mesoscopic systems.  It has an original design providing uniform wideband coupling from 2-2000 GHz, low background noise, high sensitivity, and narrow linewidth.I describe the operating principle and design of the spectrometer, show preliminary results demonstrating proof-of-concept, and outline three experiments which exploit the spectrometer to address important issues in condensed matter physics.  The experiments are: measuring the lifetime of single quasiparticle and excited Cooper pair states in superconductors, a topic relevant for quantum information processing; determining whether graphene has a bandgap, a fundamental yet unresolved question; and recording a clear spectroscopic signature of Majorana bound states in topological superconductor weak links.Various applications of the superconducting circuits developed for the spectrometer include a Josephson vector network analyzer, a cryogenic mixer, a THz camera, a detector for radioastronomy, and a scanning microwave impedance microscope.  In itself the proposed JJ spectrometer is a general purpose tool that will benefit resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EFFECT OF AEROSOL PARTICLES ON AIR QUALITY AND CLIMATE CHANGE' (EFAPAC).

assistant: **Concept**

Health effects due to air pollution and the potential detrimental effects of climate change are among the most important current environment-related problems. Quantifying the effect of aerosols on the planet’s radiative balance is one of the most urgent tasks in our efforts to understand future climate change. The contributions of the various aerosol sources, the role of long-range transport, and the contribution of primary and secondary particulate matter to the ambient aerosol concentrations over Europe are still largely unknown. The proposed work has two objectives: (i) Reduction of the current uncertainty of the impact of aerosol particles on climate and quantification of the relationship between anthropogenic aerosol and regional air quality. To achieve this objective, the proposed work will concentrate on the areas of greatest uncertainties. We will identify and quantify the processes and sources governing global and regional aerosol concentrations, and quantify the feedback processes that link climate change and atmospheric aerosol concentrations with emphasis on the production and loading of natural aerosols and their precursors; (ii) Development and application of a fundamental capability to simulate the indirect climatic effect of aerosols in climate models, based on integration of size-resolved treatment of tropospheric aerosols and explicit aerosol-cloud microphysics into a Global Climate Model. The proposed work will produce advanced aerosol and cloud models that can be used by global and regional climate and air quality modeling scientific communities. (i) will be achieved by improving our understanding of atmospheric aerosol physics and chemistry, which, in turn, will enhance our ability to forecast short-term regional air quality, as well as to estimate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Disruptive Economies and Macrolithic Technologies in the Euro-Mediterranean Bronze Age' to be submitted under Horizon Europe.

assistant: **Abstract**

Between 3000 and 1500 BCE, a relatively small number of Mediterranean and European societies underwent deep changes, leading tolarge-scale, centralised, and highly unequal economic and political entities. Most of these Early Bronze Age “innovative regions” areidentified with the rise of a warrior elite or aristocracy, craft specialisation, agricultural intensification, and expanding exchangenetworks. What caused the rapid emergence and, centuries later, sudden collapse of these “disruptive societies” is one of history’smost important open questions, particularly in view of their triggering effect on the development of statehood beyond AncientMesopotamia and Egypt. CORNERSTONES will examine the economic factors underlying and connecting the rise and fall of Early Bronze Age disruptive societies by drawing on the heuristic potential of macrolithic tools. No artefact category of later prehistory was involved in a larger range of productive processes, from food processing to metal forging. Ubiquitous and plentiful, their numbers are directly related to production intensity, while their distribution reveals economic specialisation and centralisation. The limited attention so far paid to macrolithic tools in prehistoric archaeology is mainly due to the complexity of the required interdisciplinary approach. CORNERSTONES will meet this challenge with a set of innovative research tools from the fields of geology, material mechanics, functional analysis, ethnoarchaeology, and network analysis. New procedures and scientific standards will be combined in a comparative paleo-economic investigation of three of the most prominent Euro-Mediterranean Bronze Age contexts with disruptive trajectories: the Aegean Bronze Age, including Minoan Crete, the Únětice society in Central Europe, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multimedia Information Window for National Hosts' (INFOWIN).

assistant: **Innovation**

The objective of the InfoWin project is to provide the ACTS Information Window. This window allows information to flow from ACTS projects to the outside world, and also helps the outside world to be visible to the ACTS projects.The window is intended to ensure that the work carried out in ACTS is timely and relevant. It ensures that ACTS participants keep an up-to-date view of the development of the market and its needs, and simultaneously it ensures visibility of the work carried out within ACTS.To maximise the synergy to be obtained by carrying out the research and development of ACTS within the overall framework of a collaborative programme, the InfoWin project provides support for the internal communication of the ACTS programme, both within the projects and between projects and the Commission.The goal of InfoWin as a service project is to provide a variety of information and news products and to provide services to the ACTS projects.ACTS Information WindowThe main entry to the ACTS Information Window, URL http://www.infowin.org.The ACTS Information Window is the main on-line dissemination forum of the ACTS programme. It provides an easy access-point to a number of the services, to information on ACTS, and to the InfoWin publications.InfoWin produces four regular information products:Newsclips are published and distributed via WWW and email twice a month.They inform about ACTS projects and new items in the advanced communications technologies.Bulletins, which appear four times a year, cover special research topics of ACTS or other topics of current interest, important events, articles, and publications. It is mostly dedicated to ACTS projects.Thematic Issues published quarterly cover a special research topic of ACTS or other topics of current interest in depth. A Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Directed evolution of new biocatalysts using the alpha/beta-barrel scaffold'.

assistant: **Innovation**

The aim of this project is to create novel or improved enzyme activities for the widespread use of biocatalysts in industrial processes. It will combine rational design on the basis of known protein structures and directed evolution methods mimicking evolution in nature in the laboratory time scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Cocultivation of microorganisms as a strategy for discovery of new natural products with antimicrobial properties'.

assistant: **Concept**

New antibiotics are urgently needed to combat persistent, emerging and re-emerging infectious diseases. Historically, microbial natural products have been a prolific source of antibacterials, and the screening of microbial extracts has yielded many classes of antibiotics. However, this approach was largely abandoned by big pharma because of the high rates of rediscovery of known antibiotics, and the general belief that there were very few new antibacterials to be discovered from microbial natural products.Sequencing of bacterial genomes has changed that view completely. In many bacteria there are far more gene clusters directing the biosynthesis of antibiotic-like metabolites than natural products known to be produced by the organism. These so-called “cryptic” gene clusters (cryptic because their metabolic products are not known) are often silent (not expressed) under standard laboratory conditions, and can represent up to 80-90% of the secondary metabolite gene clusters in some bacteria.In recent years we have witnessed an increased in the employment of cocultures (i.e. cocultivation of more than 1 microorganism) as a strategy to discover new natural products by exploiting cross-communication processes mediated by diffusible signalling molecules.In this project we will carry out an in-depth study of the capacity of this strategy to discover new antibacterials from microbial metabolites. Objectives: a) Cocultivation of microorganisms from an actinomycete-based microbe collection employing a specifically designed dual fermentation system. b) Antibiosis screening of the obtained microbial extracts using modern high-throughput technologies; identification of active extracts c) LC-MS based chemical dereplication of active extracts using in-house and external natural product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimization of bacillus as a cell factory' in the context of a Fourth Framework call.

assistant: **Objectives**

Bacillus is the industrial host of choice for the high yield production of bacterial enzymes. A number of problems have hampered the expression of heterologous proteins of industrial interest by Bacillus species. The solution to this problem lies to a large extent in the identification and control of factors affecting (a) genetic stability of cloned genes, (b) the expression of economically relevant genes and (c) the amenability of industrial Bacillus strains to recombinant DNA technology. The main objective is to construct Bacillus strains which are more suitable for industrial use, by exploring the interface between the recent findings in bacterial physiology, functional genomics and the applied biotechnology. The goal of this project is to optimise Bacillus as a cell factory for the production of proteins of industrial and/or biomedical interest and to characterize bottle-necks detected under fermentation conditions. Our objectives are: i) to minimize the genome size of B. subtilis 168, ii) to analyse the factor(s) that govern the amplification of genetic information and its stability, iii) to characterize the factors that control the metabolic fluxes and iv) to optimize controlled gene expression. We propose to remove dispensable loci of the genome of B. subtilis, to direct the consumption of resources to the production of desired products. We will develop tools to increase controlled gene expression with the aim of optimizing Bacilli as a cell factory. The availability of the entire DNA sequence of the B. subtilis genome will be of great help for these purposes. We will engineer the sugar uptake to minimize the load on the metabolic flux in the manipulated strains. The full exploitation derived from such an analysis will be of direct relevance to the competitivenes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Dipolar Physics and Rydberg Atoms with Rare-Earth Elements'.

assistant: **Objectives**

Strongly magnetic rare-earth atoms are fantastic species to study few- and many-body dipolar quantum physics with ultracold gases. Their appeal leans on their spectacular properties (many stable isotopes, large dipole moment, unconventional interactions, and a rich atomic spectrum). In 2012 my group created the first Bose-Einstein condensate of erbium and shortly thereafter the first degenerate Fermi gas. My pioneering studies, together with the result on dysprosium by the Lev´s group, have triggered an intense research activity in our community on these exotic species. The RARE project aims at converting complexity into opportunity by exploiting the newly emerged opportunity provided by magnetic rare-earth atoms to access fascinating, yet rather unexplored, quantum regimes. It roots into two innate properties of magnetic lanthanides, namely their large and permanent magnetic dipole moment, and their many valence electrons. With these properties in mind, my proposal targets to obtain groundbreaking insights into dipolar quantum physics and multi-electron ultracold Rydberg gasses:1) Realization of the first dipolar quantum mixtures, by combining Er and Dy. With this powerful system, we aim to study exotic states of matter under the influence of the strong anisotropic and long-range dipole-dipole interaction, such as anisotropic Cooper pairing and superfluidity, and weakly-bound polar ErDy molecules.2) Study of non-polarized dipoles at zero and ultra-weak polarizing (magnetic) fields, where the atomic dipole are free to orient. In this special setting, we plan to demonstrate new quantum phases, such as spin-orbit coupled, spinor, and nematic phases.3) Creation of multi-electron ultracold Rydberg gases, in which the Rydberg and core electrons can be separately controlled a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects and mechanisms of bt transgenes on biodiversity of non-target insects: pollinators, herbivores and their natural enemies' under Fifth Framework.

assistant: **Concept**

The effects of transgenic, insect-resistant (Bt-) crops on biodiversity of non-target herbivorous insects and their natural enemies, and pollinators will be investigated. Four toxin/crop combinations will be used for testing effects ofinsecticidal proteins from Bacillus thuringiensis expressed in the crop plants on associated insects, on different organizational levels. Both in the laboratory and in limited field experiments, effects of transgenic on the biodiversity of the associated insect community will be studied. The mode of action of Bt toxin in beneficial insect will be studied in more detail. Molecular tools consisting oscine micro arrays will be developed for fast and efficient observation of effects, based on changes in gene expression patterns. The project will deliver contributions to a solid scientific foundation for EU policies and regulations for release of transgenic crops, and tools for monitoring effects on biodiversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Where Silicon Valley meets Silicon Prairie: Exploring the Research and Development of Digital Farming Technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

This research aims to understand how, by whom, and with what intentions and objectives digital farming technologies are being developed, and what this means for the future of food production. Digital innovations in agriculture have attracted much interest in recent years, and are often touted as the solution to feed the world with less resources, inputs, pesticides, human labour, and detrimental environmental impacts than the current food system. At this point, however, it is unclear whether digital farming technologies will indeed fulfil such promises. This research project presumes that digital farming technologies need to be studied at their initial research and development levels – to fully understand the various motivations, goals, practices, and decisions made during these early, but critical, stages of technological development – and therefore the products that will come to market. Long before technologies arrive at the farm, various actors – scientists, technology developers, engineers, Start-Up entrepreneurs, ‘urban hipsters’, financiers, and business leaders – begin to imagine, develop, and make key decisions concerning the future use of technologies. Understanding these initial stages of development will allow us to gauge how these processes determine how, by whom, and under what conditions digital farming technologies will be used in society. This research will be done by undertaking participant observation and qualitative interviews within two of the most expansive and innovative clusters of agricultural technology development in the world, the University of California (UC) system, coupled with Silicon and Central Valleys in the US; and Wageningen University & Research (WUR), with Food Valley, in the Netherlands. Within these sites, I focus on two major fun