RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Outer Membrane Vesicles (OMVs) from “Vaccinobacter”: A Synthetic Biology approach for effective vaccines against infectious diseases and cancer' (OMVs), addressing dissemination and exploitation.

assistant: **Impact**

This proposal intends to apply Synthetic Biology to create a new bacterial species, Vaccinobacter, devoted to the production of multivalent, highly effective vaccines. The project originates from the evidence that Outer membrane Vesicles (OMVs) naturally produced by all Gram-negative bacteria can induce remarkable protective immunity, a property already exploited to develop anti-Neisseria vaccines now available for human use. OMV protection is mediated by the abundance of Pathogen-Associated-Molecular Patterns (PAMPs), known to play a key role in stimulating innate immunity. Moreover, OMVs can be engineered by delivering recombinant proteins to bacterial periplasm and outer membrane. Intrinsic adjuvanticity and propensity to be manipulated potentially make OMVs an ideal vaccine platform, particularly indicated when antigen combinations (for pathogens with genetic variability) and strong potentiation of immunity (for the elderly and cancer) are needed. However, full exploitation of OMVs as vaccines is prevented by:  i) presence of potentially reactogenic compounds such as LPS, virulence factors, and toxins, ii) presence of several irrelevant proteins, which dilute immune responses, iii) lack of broadly applicable molecular tools to load OMVs with foreign antigens. Scope of the project is to provide novel solutions to solve these limitations and demonstrate the unique performance OMVs as vaccines by testing them on complex pathogens and cancer. Main project activities are: 1) remodelling of E. coli genome to create “Vaccinobacter”, a “living factory” of OMVs deprived of all unnecessary components but carrying the relevant immune potentiators, 2) characterization and optimization of the immune stimulatory properties of OMVs,  3) development of novel methods to incorporate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Managing People - How Employees' Social Preferences Shape the Returns to Management Practices' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Many management practices incur important consequences for the distribution of resources as well as for workers' monetary and non-monetary benefits. It is therefore likely that employees' social preferences - like reciprocity, fairness concerns - matter for the effectiveness of management practices and play a major role in the productivity of firms. I analyze the causal effects of management practices and study to what extent employees' social preferences shape the returns of the considered management practices. In RCTs, I randomize management practices within firms to identify their effects on multiple outcomes, e.g. sales and turnover. I then collect survey data on employees' social preferences and managers' beliefs to study how social preferences shape the returns of the management practices. PROJECT A: In a bakery chain with a control-oriented culture, I reduce for a randomly selected half of the 150 stores documentation duties that workers perceive as a sign of distrust. I examine the causal impact of employee control on performance and study whether the effects interact with workers' reciprocity. PROJECT B: In a random sample of 234 grocery stores, bonuses are allocated equally among workers. In the remaining stores, managers have full discretion regarding the bonus allocation. I study whether managers' discretion causally affects performance and examine to what extent the effect is associated with employees' fairness perceptions and managers' beliefs about workers' distributional preferences. PROJECT C: In a kitchen manufacturer, 301 workers employed in various units whose task it is to identify kitchen planning errors do not interact and share knowledge. I introduce a new component into the organizational structure: regular meetings in which randomly selected wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable Closed Loop System for Recycling of Carpet Materials' (RECAM) under Fourth Framework.

assistant: **Objectives**

BE95-1337 Sustainable Closed Loop System for Recycling of Carpet Materials The European carpet industry and the strategic suppliers of raw materials for the manufacturing of carpets have a strong need for a cost-effective and ecological justified waste management system for post-use carpet waste. This in order to reduce the high-rising costs of disposal by landfill and Municipal Solid Waste incineration. Especially the rising costs of MSW-incineration is critical because landfill will be strongly restricted in the EU in the near future, while other systems that could manage the disposal of around 1.6 million tons per year of carpet waste are not yet developed. The chemical companies DSM and EniChem, the European Carpet Association represented by GuT and the German institute for carpet research TFI will take the initiative to develop a sustainable closed loop system for recycling and re-use of materials and energy recovery from post-consumer as well as from post-industrial carpet waste. Major targets of the proposed developments are to achieve substantial cost reductions (approx. 200 - 400 MECU = 30%) and increased environmental benefits (approx. 125 - 300 MECU = 60%) with the RECAM-system, compared with the results of waste management by MSW-incineration. Other important targets are to recover and recycle in an economic way valuable materials from carpet waste, like caprolactam, PA 6, PA 6.6, PA 6 + 6.6, PP and woolfibres, from which the partners and associated partners can take advantages for their core-business. The proposed RECAM-system to be developed, includes all necessary steps of collection and logistics as well as of technologies for the identification, sorting, cleaning, size reduction, separation and purification of the material components, recycling of valua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exosome inspired RNA communication between HiErarchicaL poLymer prOtocells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The mimicking of cellular communication pathways and genetic information transfer in synthetic systems is an important target for researchers. These artificial cell systems have the potential to increase understanding of biological and cellular processes, while also having potential applications in healthcare technologies. This project will involve the investigation of exciting new stimuli responsive and highly tuneable hierarchical polymer protocells, and their application in RNA-based communication. Previous generations of polymer protocells have been shown to allow diffusion based communication with small molecules and naked DNA strands – the project will expand upon this by investigating polymersomes as mRNA shuttles between distinct protocell populations. This exosome inspired system will allow the typically unstable mRNA molecules to be protected from degradation in the external medium, thus opening the door to much more lifelike systems, and possible therapeutic applications. The proposed research project is strongly multidisciplinary, and involves a combination of polymer chemistry, nanomaterials engineering, cell biology, and imaging techniques. RNAhello includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. Results have the potential to increase understanding of biological mechanisms in relation to the complex hurdle of the nucleic acid based transfer, whilst also providing innovative platform material for treatment of disease. Additional project goals include: engaging with the non-scientific public through outreach methods; gaining of further commercial training for potential exploitation of research; presentation of research results at international conferences; and the preparation of ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Photonic molecule microcombs', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Frequency combs are remarkable photonic devices for precision frequency synthesis and metrology. The core technology behind conventional frequency combs is a mode-locked laser. Today, so-called microcombs constitute an alternative for the generation of a frequency comb on a chip-scale microresonator. Microcombs have a frequency separation between lines that is orders of magnitude larger than standard mode-locked lasers. The combination of small footprint and large line spacing is opening up entirely new scientific and technological opportunities, one of the most prominent ones being optical communications. However, one outstanding problem with microcombs is their fundamentally limited power conversion efficiency, which hampers the potential applications of this otherwise promising technology. In my ERC CoG DarkComb, we have overcome this issue by developing an innovative arrangement of linearly coupled microresonators implemented with an original silicon nitride fabrication process that features ultra-low optical losses. The aim of this ERC PoC is to conduct a yield analysis of our technology, investigate the freedom to operate and pursue a rigorous market evaluation. These results will form the basis for the development of a sound business strategy upon the conclusion of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of the Determinants of Heterochromatin Formation and Maintenance' (HETCHROMPROJECT) targeting Seventh Framework.

assistant: **Abstract**

Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also implicated in programming patterns of genes expression, in particular during cellular differentiation. Several evolutionary conserved molecular pathways have been implicated in the initiation, propagation and maintenance of heterochromatic domains during cell divisions. However, the formation of heterochromatin is an intricate process and despite much research many facets remain to be understood. The overall goal of this proposed research is to gain insight into the formation and maintenance of heterochromatin. The first aim of this study will propose experiments designed to analyze the contribution of the centromere CENP-B proteins to heterochromatin organization and gene expression in the genetically tractable model organism S. pombe. CENP-B are evolutionarily conserved sequence-specific DNA-binding proteins that associate not only with centromeric heterochromatin but also with the heterochromatin of silenced genes and the mating-type locus in yeast. Different studies point to an important role of the CENP-B proteins in heterochromatin formation at several locations in the genome, but their exact molecular role(s) is still debated. The second part of this study will aim to identify additional proteins involved in heterochromatin formation by means of a two-step genome-wide screen in the fission yeast. This screen will be based on properties of centromeric heterochromatin and is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DEmonstration of COunterTErrorism System-of-Systems against CBRNE phase 1' in the context of a Seventh Framework call.

assistant: **Objectives**

DECOTESSC1 proposes a DEmonstration of COunterTErrorism System-of-Systems against CBRNE phase 1. A thorough understanding of the system-of-systems’ structure will be developed, the requirements for an ideal system will be proposed as well as a description of the current state-of-the art. A gap analysis will reveal the differences between the current situation and the ideal situation. The gaps thus obtained will be ranked. Also, in order to fill the gaps a strategic roadmap will be developed to guide the improvement cycle by proposing, technological and organizational topics to be addressed and implemented in a future phase 2 of the demonstration project CBRNE counterterrorism. This all will be primarily done by a Core Group of partners. In addition, to achieve all this, the DECOTESSC1 project will, on top of the efforts of the Core Group, consider the needs of the various stakeholders (government representatives, local authorities, users with different think-tanks, universities, RTO’s and industry (including SME’s)) by direct interaction. This will be achieved by involving the stakeholders, collected into an Expert Group, continuously by organizing workshops at relevant moments during the work of DECOTESSC1, by organizing a mid-term stakeholders meeting and well as a final symposium. Interviews with individual stakeholders will also be a mechanism for interaction. All interactions above will not only provide input for DECOTESSC1’s work but also provide dissemination of its findings throughout the EU community and raise awareness for this very important subject area in the mean time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Main Group Metals in Oxidation State Zero for Bond Activation and Catalysis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Historically, main group metal organometallics are used as stoichiometric reagents in organic synthesis. This holds especially for highly polar s-block metal compounds like BuLi or Grignard’s. Only since the start of this century, it has been recognized that they also make for remarkably versatile catalysts. Parallel to these developments, the low-oxidation-state chemistry of the early main group metals emerged with the seminal isolation of first MgI complexes. Since 2007 numerous examples have been reported. First highly reactive complexes of an s-block metal in the formal zero-oxidation-state (ZOS) were reported by our group (“Strongly reducing magnesium(0) complexes”, Nature 2021, 592, 717).MM-ZERO aims to develop main group metal chemistry in the ZOS. In contrast to transition metals, for which there are many examples of TM(0) complexes, it is a bold challenge to isolate complexes of electron-rich main group metals. This holds especially for the electropositive s-block metals. Devoid of d-orbitals for backbonding, they easily oxidize. Building upon our preliminary work, we propose strategies to advance ZOS main group metal chemistry and push the frontiers of knowledge. Smart ligand design and the introduction of ball-milling are key to access hydrocarbon-soluble complexes with ZOS-metals of groups 1-3.While this first part is of fundamental nature, the second part of the project aims to activate main group metals for hydrogenation catalysis. Preliminary work shows that Ba activated by Metal-Vapour-Synthesis (MVS, i.e. cocondensation in an organic matrix) is an unexpectedly active alkene hydrogenation catalyst. Moreover, in combination with MVS-activated Fe, benzene can be even hydrogenated at 20 °C. Ba/Fe-cooperativity is demonstrated by the fact that both metals al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tracing single-cell scale chemical signaling between interacting soil fungi' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Multiple species of fungi co-exist in soils and play an important role in biogeochemical cycles. To survive in a resource limited environment, they have developed the means for interspecific communication and warfare via an arsenal of secreted secondary metabolites. Specific ecological role of those metabolites and the extent to which they affect biogeochemical cycling during fungal interactions remains unknown. Because they are secreted and act at a single-cell scale, tracing them ‘then and there’ can aid in identifying potential triggers for their production and clarifying their function. Currently used methods have either insufficient resolution or are destructive, and are not suitable for such analyses. Here, I will use my expertise in spectroscopy techniques to (1) establish experimental protocols for the single-cell scale fungal secondary metabolite identification and characterization using surface-enhanced Raman scattering (SERS) microspectroscopy - a method that employs optical properties of gold nanoparticles for molecule specific sensing and that has been shown in biomedical research to have an extraordinary potential for studying microbial metabolic processes. I will combine it with microfluidics based soil chips, that provide visual access to and mimic real ecosystems via control over biotic and abiotic environment of soil microbes. Ultimately, my aim is to offer the community of soil fungal ecologists with a game-changing new tool to study ecosystem functions of secondary metabolites in more realistic settings. I will then use the approach to (2) determine how interspecific fungal interactions under varying nutrient conditions affect the composition of their secondary metabolome and its functions live and at single-cell scale. Additional transcriptome analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From cooperation to dishonesty: How concern for others can lead to unethical behavior' (BEHAV-ETHICS), addressing dissemination and exploitation.

assistant: **Impact**

Cooperation with others is common and beneficial in organizational as well as personal settings. Working together allows people to achieve mutually beneficial outcomes and prosper. While the benefits of cooperation are clear, recent work suggests that when people work together (rather than alone) they are more likely to engage in dishonest acts aimed at boosting their profit, apparently because it is easier to justify lying when others share the profit. It thus seems plausible that experiencing cooperation from counterparts may increase people’s likelihood to reciprocate, even when reciprocation requires bending ethical rules. The main aim of the proposed research is to explore whether, and how, cooperation increases people’s concerns regarding their counterparts’ outcomes, and thus encourages bending ethical rules in order to profit the cooperating others. Such dishonest reciprocation, may not only allow one to display care about the other’s outcome, but also increase the likelihood of future cooperation, potentially leading to a slippery-slope spiral of unethical misconduct. Addressing this possibility, a theoretical process-model is developed in which the degree of unethical behavior depends on the degree of experienced cooperation. Specifically, the proposed research has three aims: Identifying (1) situations in which experiencing cooperation translates into dishonest behavior benefiting the other; (2) psychological mechanisms underlying such dishonesty; and (3) situational factors that may remedy such undesired unethical behaviors. The model is systematically tested by employing experimental social psychological and behavioral economic paradigms. Beyond its theoretical contribution to understanding the effects of cooperation on unethical behavior, the project has s