RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Processes and Outcomes of Educational Evaluation from a Cross-Cultural Perspective' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The full complexity of educational evaluation at various levels (i.e., system, school, classroom, and student) in different countries has hardly been recognized. It constitutes a tremendous barrier to consolidate theories on evaluation, and for countries to draw on successful experience and implement targeted educational policies for better quality and effectiveness. Important barriers include the insufficient methodology to soundly compare multiple countries and a cultural insensitive approach to unfolding evaluation processes and outcomes. This project aims to provide a comprehensive framework for the dynamics of evaluation with a solid cross-cultural research methodology. Using self-report data in 70 countries/economies in the 2015 Programme for International Student Assessment (PISA), this project delineates the pathways in processes and outcomes of educational evaluation in 70 educational systems by integrating policies at system level, practices in schools and classrooms, and student assessment outcomes with demonstrated comparability of data. Study 1 has a methodological focus to analyze scalable measures and their cross-cultural comparability. It tests whether self-report multiple-item measures from school principals, teachers, and students across countries reach approximate measurement invariance to ensure proper comparisons. Study 2 tests the effects of accountability policy, country affluence at country-level, and various evaluation practices including the feedback mechanisms at school and teacher levels, and the cross-level interactions on a broad range of student outcomes such as achievement, motivation, wellbeing, and test anxiety. This project contributes to theory building on educational evaluation from a cross-cultural perspective and identify effective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Turning gold standard quantum chemistry into a routine simulation tool: predictive properties for large molecular systems'.

assistant: **Innovation**

We propose comprehensive theoretical method development targeting a long-standing dilemma in molecular quantum simulations between controllable predictive power and affordable computational time. While theoutstanding reliability of quantum chemistry’s gold standard model is repeatedly corroborated against experiments, its traditional form is limited to the size of an amino acid molecule. By exploiting the short-range natureof leading interaction contributions, a handful of groups, including ours, have recently extended the reach ofsuch quantitative energy computations up to a few hundred atoms. However, these state-of-the-art models arestill too demanding and are not at all equipped to compute experimentally relevant dynamic, spectroscopic, andthermodynamic molecular properties.Thus, to break down these barriers, we will further accelerate our cutting-edge gold standard methods upto few 1000 atoms via concerted theoretical and algorithmic developments, and high-performance softwaredesign. Additionally, we will take into account biochemical, crystal, and solvent environment effects via cost-efficient embedding models. For the first time, we will also derive and implement practical approaches tocompute static and dynamic observable properties for large molecules at the gold standard level. The exceptional capabilities of the new methods will enable us to study challenging chemical processesof practical importance which are not accessible with chemical accuracy for any current lower-cost alternative.We aim at modeling and understanding intricate covalent- and non-covalent interactions governing supramolecularand protein-ligand binding as well as the mechanism of organo-, organometallic, surface, and enzyme catalyticreactions.Once successful, this project we will deliver gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MUCOSAL VACCINES FOR RESPIRATORY DISEASES BASED UPON NASAL ADMINISTRATION' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Respiratory diseases represent a serious threat to health in both the young and old. Viruses and bacteria that cause these diseases enter the body through the mucosal surfaces of the nose, lungs and gastrointestinal tract. A vaccine that provides protection against initial infection would be very advantageous. Classical vaccines are normally administered by injection but they do not provide protection in terms of preventing invasion. In contrast, a mucosal vaccine that is administered to the site(s) of pathogen ingress can provide good long term protection.Mucosal vaccines achieve this effect by the induction of a secretary antibody (IgA) that interacts and neutralises the invading antigen (pathogen). Moreover, inoculation at one mucosal site can provide protection at other distant mucosal sites through the Common Mucosal Pathway. Mucosal vaccines also have the advantage that they can be easily administered and do not require injection.As a spin off from a programme on the nasal administration of biotechnology products in the form of peptide and protein drugs, West Pharmaceutical Services has discovered that some of its proprietary nasal delivery systems for drugs could also be appropriate for the delivery of mucosal vaccines. Diphtheria, caused by the organism Corynebacterium diphtheriae was chosen as the target disease. The project aimed to validate the nasal vaccines system before being optimised and scaled up for testing in human trials.A new non-injectable mucosal vaccine for the prophylaxis of diphtheria cough could have enormous potential in both social and financial terms. The existing diphtheria toxoid vaccine is associated with certain side effects and does not induce mucosal immunoglobulin A (IgA) antibodies to diphtheria that are usually detected following t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced mass spectrometry approaches to reveal nucleic acid folding energy landscapes' (DNAFOLDIMS), addressing dissemination and exploitation.

assistant: **Impact**

50 years after the discovery of the DNA double helix, the variety of structures that nucleic acids can adopt continues to surprise the scientific community. Specific structures and conformational changes are linked to important functions in cell regulation. Understanding the principles that govern how small molecules such as natural metabolites or synthetic drugs modulate the nucleic acid structures is of prime importance for molecular biology and pharmacology. The field however suffers from the lack of suitable experimental tools to monitor all assemblies and structures formed when a small molecule encounters its targets.The goal of my project is to develop unique mass spectrometry-based approaches to detect, quantify and characterize all these assemblies and structures. Our team’s strength will be to integrate a multidisciplinary approach, from physical and analytical chemistry to molecular biology. We will address the fundamentals of nucleic acid ionization and transfer in the gas phase, develop a unique instrumental setup combining mass spectrometry, ion mobility and circular dichroism ion spectroscopy, and apply these new approaches to biologically important nucleic acids, in order to reveal the mechanisms of ligand-induced conformational changes in important regulatory structures such as G-quadruplex or riboswitches.This research will also have broader impact, as the approaches and concepts developed here for nucleic acids will contribute fundamental advances in mass spectrometry, and will be transferrable to other supramolecular or biological complexes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intermolecular Asymmetric Halogenations of Olefins' (AsymHalogenation).

assistant: **Concept**

The main goal of this project is the development and optimization of the first general methodology for intermolecular asymmetric halogenation of olefins and the application of NMR spectroscopy to understand and control this process. The carefully controlled application of nucleophiles in intermolecular asymmetric halogenation would be extremely desirable because it could be used as a powerful tool to generate a wide array of structural motifs of exceptional impact for the society. In this project, the asymmetric catalysis is proposed by stabilizing a bispyridine halonium complex in a chiral environment during both reaction with the olefin and subsequent attack of the nucleophile, i.e. a stoichiometric amount of stabilized complex will react with the double bond and then be exposed to the incoming nucleophile, all under the regime of the generated chiral environment. Thus, the project will encompass the synthesis of structurally diverse bispyridine ligands and their halonium complexes and then, the elucidation of the influencing factors on the kinetics of the halogenation reaction by UV and NMR spectroscopy. Ultimately, the knowledge gained in this part of the project will be transferred to the design of bispyridine ligands containing asymmetric centers to induce chirality in the halogenation reaction. One or several series of ligands will be produced and screened for chiral induction via chiral HPLC of the product mixture. The applicability of the approach on several different model reactions will be proven. The chiral products should be obtained with a high degree of regio- and enantioselectivity. The bispyridine ligand used to form the stabilized complex can be recovered by extraction or precipitation and therefore its use is expected to be feasible in large scale rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A comprehensive approach to value transmission in the digital age' in the context of a Horizon Europe call.

assistant: **Objectives**

The EU aims to promote common values and beliefs among members. Classic research establishes parents as the main role models for such transmission. However, children today learn values from new role models, such as social media influencers (SMIs), users who share content to acquire followers. The project will construct a comprehensive value transmission theory applicable across contexts and adapted to the digital age. It will define essential value transmission aspects: source, channel, message, receivers. The source studied will be mothers and SMIs. The channel will be conversations and online exchange of content and engagement. The message will be a set of values motivating prosocial behavior, including but not limited to moral values, and the balance among them. Explicit and implicit messages will require varying processing systems. Child and adolescent receivers will be active partners, choosing, negotiating, and transmitting values. I will investigate value transmission practices used by interaction partners to convey messages; I will test the effectiveness of practices in promoting value similarity, moral reasoning and prosocial behavior; Finally, I will examine interactions between mothers and SMIs value transmission processes.In 7 studies, I will (1) longitudinally study mother-child conversations on prosocial behavior in daily life and in social media. Conversations will be analyzed thematically, longitudinally across 2 years, and moment-to-moment; (2) analyze values in SMI content and investigate their relations with follower engagement, applying manual and artificial intelligence coding; (3) Last, I will experimentally test the effectiveness of value transmission practices, including cases of source disagreement.The project sets the stage for research into va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Interventional Imaging Operating System' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The scope of the present consortium is to provide technology and training for the integration of ultrasound and biophotonics based imaging with magnetic resonance imaging (MRI), Computed Tomography (CT) and Positron Emission Tomography (PET) to define the specs of an Integrated Interventional Imaging Operating System (III OS) aimed at minimal invasive treatment of common life-threatening disorders, e.g., cancer, cardiovascular disease and structural heart defects. Effective therapy of these conditions will require a range of safe surgical and interventional devices used with the necessary visualization and tracking under real-time image guidance. The consortium includes a critical mass of industrial and university research institute partners with high expertise in design, development, and manufacture of these devices and instruments. To ensure medical the safety and economical usability of the system and to allow an optimal integration into the future hospital workflow, 6 university hospitals will contribute their clinical and administrative expertise to the consortium in the fields of Interventional Radiology/Cardiology, Anaesthesia, Oncology, General and Cardiovascular Surgery and preclinical Image guided procedures. The consortium of the IIIOS research and training process includes two Biomedical Technology Societies: DGBMT and SMIT&MEDIS Foundation in Rumania providing expert networking and conference organization. The is involved in the consortium and will play a key role in the exchange of knowledge and expertise to the new member states of the EU through hosting conferences such SMIT 2009 in Sinaia (www.smit2009.com).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Studies on the role of orphan nuclear receptors on cholesterol catabolism as new pharmacological targets in cardiovascular diseases and search for ligands modulating their activity (NORTH)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The general objective of this project is to study new aspects of the molecular regulation of cholesterol metabolism by orphan nuclear receptors and the contribution of the underlying mechanisms to cholesterol homeostasis. To achieve the objective of this application we will pursue the following specific aims: 1. Analysis of the role of orphan nuclear receptors on the regulation of the expression of genes involved in cholesterol metabolism. 2. Systematic identification of novel target genes regulated by orphan nuclear receptors. 3. Determination of the crystal structure of the legend-binding domain of HNF-4, CPF, SHP and COUP-TFII. 4. Search for legends for HNF-4, CPF, SHP and COUP-TFII. 5. In vitro and in vivo analysis of the newly identified legends. This project will allow finding new drug targets for novel treatments of hypercholesterolemia to lower the risk of developing atherosclerosis an the incidence of cardiovascular diseases associated with this metabolic disorder.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'LIGHT13:Turn on the Light on Science' under Seventh Framework.

assistant: **Concept**

Light’13 is conceived as an event driving a cultural change about researchers for the benefit of research-end users. Light’13 will take place in Rome, the capital of the country, and in 1 additional location in the South of Italy, Naples. Light’13 will last from 5.p.m. on 27 September to 1.a.m on 28 September. Light is celebrating its 6th year of life. As in previous editions, we dedicate the RN to a specific theme. This year Light’13 is dedicated to: “What’s up with Science?” in order use news broadcasted by TV and media as a springboard for dialogue with the public and to improve the image of scientists. In order to ignite people’s curiosity towards scientists’ work, Light’13 will set-up a number of actions/events during the whole RN. The actions will be run in continuation in all the locations allowing visitors to freely pass from one area to the other without waiting for something to happen.The activities will be organised around 6 main areas:o Hands-on workshops with live demonstrations and hands-on experiments;o “Big ideas from young minds” area, where potential tomorrow's scientists will present their special achievements;o4kids activities for children;o “Science Globe Theatre” where groups of artists/sportsmen that have at least one member of the performing team actively engaged with scientific research will be on stage during the whole RN;o Outside activities on sports and musico European Corner with information on Europe and gadgets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'INTERMODAL GLOBAL DOOR-TO-DOOR CONTAINER SUPPLY CHAIN VISIBILITY'.

assistant: **Innovation**

Main challenges facing today’s international intermodal door to door container transport system are logistics efficiency and security which may lead to contradictory business strategies. However, a safe, secure and efficient intermodal transport system is a common goal of all the participants in the supply chain. INTEGRITY will reconcile these challenges and link all elements of the supply chain through accurate, reliable, timely, value adding tracking and status data thus enhancing trade facilitation through the use of high quality, neutral, sophisticated equipment, including scanning equipment in ocean ports, whilst remaining accessible to all eligible stakeholders, large and small. INTEGRITY will develop procedures and technologies allowing for supply chain visibility, security and predictability. Based on consensus, the project partners (3PLs, cargo owners, logistics companies, research organisations, Customs Authorities, technology companies, IT developers, (inland) terminal operators) will guarantee a successful implementation in a real environment. INTEGRITY will validate targeted and verifiable benefits through real operational business and customs operations in door to door supply chains in the major trade corridor of China to the EU via the ports of Yantian, Rotterdam and Felixstowe, using all modes of transports within the EU to various destinations. INTEGRITY is embedded into international initiatives e.g. from World Customs Organization (WCO), EU/China Customs project supported by DG TAXUD, e-Customs project, Freight Logistics Action Plan of DG TREN and to intermodal initiatives like EIRAC. It will also be combined with the AEO concept and scanning/monitoring technology and will support the “trust but verify” approach. INTEGRITY will raise the standard for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-functional DUAL PHOSphorus-based organoCATalysts for stereoselective ring-opening polymerisation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The stereocontrolled ring-opening polymerisation (ROP) of chiral cyclic esters for the preparation of biodegradable polymers with precise and finely-tuned properties remains a research challenge. Only Few catalysts/initiators have been reported to produce stereoregular high molecular weight polymers; most of them being highly sensitive and/or toxic organometallic species. Organocatalysed ROP produces polymers that are free of residual metal contaminates but to date, does not allow high productivities with high levels of stereocontrol. In this context, the multi-disciplinary proposal DUAL-PHOSCAT proposes to develop chiral tunable dual phosphorus-based organocatalysts to overcome these challenges. For this, a stepwise-synthesis strategy to tailor the organocatalyst architectures and an inventive combinatorial approach using self-assembled oganocatalysts will be investigated. The stepwise synthesis will bind together using chiral linkers, chiral phosphorus-based molecules and chiral thioureas molecules.The self-assembled dual organocatalysts will be obtained combining chiral amine-thioureas and chiral phosphoric acids. These systems will be investigated for the ROP of rac-lactide and rac-beta-butyrolactone. The proposed catalysts enable great advances in the preparation of isotactic polylactide (PLA) stereocomplex and highly tactic poly-3-hydroxybutyrate (PHB) in terms of catalyst stability, productivity, activity and stereoselectivity, in turn making these catalysts efficient green alternative to sensitive and /or toxic organometallic initiators for the synthesis of metal-free highly stereoregular polyesters under industrially-relevant conditions. The PLA and PHB obtained will find potential applications in packaging and fibers (as green alternative to petroleum-based pl