RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New frontiers in advanced glycotherapy for cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cancer remains a major cause of death despite phenomenal progress in current immunotherapy, that aims to boost host immune responses of antibodies and T cells, and their ability to distinguish cancer from normal cells. The three main cancer immunotherapies are therapeutic cancer vaccines, cellular therapeutics and immune checkpoint blockade, but those have only limited success mainly due to difficulties in identifying target antigens. Carbohydrate chains (glycans) ubiquitously occupy surface of cells, but on cancer they are aberrantly-expressed, in particular with a wide collection of sialic acid-glycans. Their antigenic complexity arise by sialic acid structure modification, linkages, length, protein/lipid scaffolds, surface organization and density. The presentation mode of glycans and their heterogeneity affect their immune recognition, but the fundamental knowledge of how these factors contribute to efficient cancer therapy in vivo has not been defined systematically. The primary objective of this proposal is to design a comprehensive novel cancer immunotherapy approach targeting glycan-neoantigens. We propose an innovative interdisciplinary approach that integrates glycobiology, immunology and nanotechnology, to design and fully investigate new frontiers in cancer GlycoTherapy in vivo. Our discovery line is based on a two-arms modular platform to study both engineered carbohydrate-cancer vaccines and T cells, and their combined effects with checkpoint blockade on therapeutic glycan immune recognition in mouse models. Efficacy will be evaluated in detail by systematic characterization of immune cell and humoral responses with cutting-edge tools, including glycan microarrays, to track response repertoire and kinetics. Successful establishment and in-depth understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conditional Measurements in Quantum Optics for Application in Quantum Information' under Seventh Framework.

assistant: **Concept**

This project points to the experimental realization of suitably designed optical states for quantum communications uses. The quantum state will be conveniently manipulated by its projection on another one of predictable properties. The process will be realized by means of a conditional measurement performing a post-selection of the beam by monitoring a suitable observable on a fraction of it. The novel aspect of the proposed research relies on the application of this methods to multimode radiation, with the aim of providing tools to efficiently transmit information along more parallel quantum channels.  Multimode quantum light will be produced by means of an optical parametric oscillator, operated in synchronously pumped configuration; this system has a huge potential for obtaining new quantum effects, and up to now, it has been very rarely used. The research will combine a theoretical description of the problem with its experimental realization.  This project will complete and enlarge the range of the applicant’s competences. To this aim, it will benefit from the high level scientific quality of the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'HUMANE: a typology, method and roadmap for HUman-MAchine NEtworks' (HUMANE).

assistant: **Concept**

Increasingly, activities in work and social life are conducted within human-machine networks, where collaboration involves many different actors; governments and organisations, individuals and machines such as smart devices, sensors and computing infrastructure. The targets of these networks can be for policy making, commercial innovation, education, improved quality of life, information exchange or resource organisation. As networks become more complex and include more connections between humans and machines, so the characteristics of those networks become important in determining the effectiveness and successful evolution of the collaborations which they support. Emerging challenges are: understanding the processes necessary for developing and maintaining human-machine networks such that they are able to deliver their intended outcomes; and applying this knowledge to support emerging networks in public, commercial and civil domains to more readily achieve key European goals.In HUMANE we will develop a typology of human-machine networks focused on characteristics of relationships between networked humans and machines such as trust, motivation, reputation, responsibility, privacy and security. We will consider health indicators for networks and create prototype tools that can be exploited through a community of stakeholders to create and enrich human-machine networks. We will propose a roadmap and methodology for the evolution of such networks, appropriate to the needs of ICT developers, building on in-depth case studies taken from R&I projects relevant to the societal DAE pillars to form a supporting framework for future thinking and ICT policy-making in Europe.The project partners in HUMANE have wide and complementary experience in social sciences and ICT R&I, essenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Indo-European Consortium for Next Generation Influenza Vaccine Innovation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The highly integrated INCENTIVE consortium represents true partnership between Indian and European/US groups that addresses the global health and economic challenge posed by influenza infections, to reduce the worldwide burden resulting from outbreaks. INCENTIVE’s strategic goals are to provide seminal knowledge on the underlying mechanisms of poor responsiveness to influenza vaccines in vulnerable individuals and advance the development of two next generation universal influenza vaccines. This is achieved by pursing the following specific objectives: 1) address the current knowledge gap by performing comprehensive immunome profiling of responders and non-responders to licensed influenza vaccines in infants, children, adults and elderly in parallel phase IV trials in Europe and India to identify the underlying mechanisms of vaccine responsiveness in different vulnerable populations and ethnical groups; 2) advance the development of two next generation universal vaccines, including an antigen presenting cell-targeted nucleic acid vaccine up to proof-of-concept for vaccine efficacy in non-human primates, and a computationally-derived second generation COBRA (Computationally-Optimized Broadly-Reactive Antigens) vaccine up to clinical development, comprising a phase I trial in Europe, a phase II trial in India and efficacy studies using an influenza controlled human challenge model; 3) identify predictive biomarkers of responsiveness to vaccination to develop new diagnostics; 4) implement comprehensive technology transfer and harmonization activities for immunological analysis and data integration; and 5) perform a health systems and investment analysis, and discrete choice experiments to assess the suitability of the developed technologies for low- and middle-income countr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Higher Education Internationalisation and Mobility: Inclusion, Equalities and Innovations' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The proposed research/innovation project (HEIM) focuses on how principles of equity and inclusion can be applied to internationalisation strategies and programmes in higher education, at both staff and student levels. It focuses on the Roma community in Europe as a critical example of a marginalised group. HEIM will interrogate and develop the concept and practices of higher education internationalisation in Europe through questions about who is able to participate in and benefit from policy initiatives and strategic interventions. It asks whether certain social groups are disadvantaged or excluded from the opportunities that mobility offers. It will examine motivations and experiences, and the hidden costs of border crossings in terms of socio-political and affective considerations. Its objectives include comparative investigation of data on who is participating in selected internationalisation programmes; producing accounts based on literature, statistical data and empirical research. It will create a set of guidelines for reflexive and inclusive approaches to the internationalisation of higher education. Through its interdisciplinary and intersectoral approaches, it will contribute to methodological innovation across different fields. It will build research and innovation capacity by constructing teams and sharing knowledge between early stage and experienced researchers. It will exchange knowledge about internationalisation programmes in the partner organisations via co-written papers, statistical datasets, literature reviews, training and workshops. The Partnership is between three universities (Sussex, Umeå and Seville) and a non-academic organisation, the Roma Education Fund (REF). Via secondments, staff exchange, training and collaborative inquiry, the project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NEUROGENESIS IN 22Q11.2 DELETION SYNDROME: ROLE OF microRNAs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The 22q11.2 deletion syndrome (22qDS) is the most common hemizygous microdeletion syndrome occurring in humans. Individuals with 22qDS show also a variety of neuro−anatomical defects.Our central hypothesis is that altered miRNAs biogenesis (caused by the hemizygous deletion of Dgcr8, one of the genes located in the 22q11.2 critical region, and required for miRNAs maturation) might impair embryonal/postnatal brain development, thus causing some of the defects observed in brains of 22qDS patients. Our working hypothesis is now further supported by the recent finding that aberrant embryonal neurogenesis is occurring in 22qDS mice and possibly in human patients. However a direct link between altered miRNAs biogenesis and aberrant neurogenesis in 22qDS is still missing.Interestingly, our preliminary results (obtained with hemizygous deletion of Dicer, a gene unrelated to 22qDS, but acting downstream Dgcr8 in the miRNAs maturation pathway) confirm and further expand the observation that reduction in miRNAs dosage affects preferentially the proliferation (or survival) of a basal neural progenitor cells in mice. Thus strengthening the hypothesis of an involvement of miRNAs in the 22qDS.In the current research proposal we aim to investigate whether altered maturation of miRNAs in brains of 22qDS mice, is affecting neurogenesis, and overall, the contribution of altered neurogenesis to the neuro−anatomical/pathological defects observed in 22qDS mice. We then plan to use induced pluripotent stem cells (iPS) from freshly collected fibroblasts of 22qDS patients, and reprogrammed toward neuronal progenitors lineages, in order to verify whether altered miRNAs biogenesis is contributing to some alterations also in a human cellular model of 22qDS.These achievements will allow the straigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'From Household Allocations to Global Inequality: New Methods, Facts and Policy Implications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

To understand and mitigate economic inequalities, both locally and globally, we need to acknowledge inequalities within households. Yet, in most empirical studies, such intra-household inequalities are disregarded mainly because we lack appropriate measurement tools and data. Not only is this problematic for inequality measurement, this lack of understanding hampers the design of cost-effective poverty reduction and child development policies. This project has five general objectives. First, I will update the facts about inequalities through direct measurement of intra-household consumption allocations, and relate these to spousal income contributions. Second, I will develop and validate novel measures of parental resource-allocation preferences and use these to study whether children are likely to benefit more if mothers, rather than fathers, receive cash transfers. Third, I will develop and validate novel measures of household decision-making and use these to investigate how targeted transfers shape women’s empowerment. Fourth, I will study whether cash transfers or an educational parenting program is most cost-efficient for child development. Fifth, I will use an integrated framework and the new tools and data, to refine our understanding of the mechanisms behind inequalities among adults and child development. Concretely, the project will contribute to our knowledge in the following specific ways. I will carry out an extensive data collection on intra-household allocations, parental-allocation preferences and women’s empowerment, in ten very diverse countries, one from each decile of the world income distribution. I will engage in a local RCT in Tanzania on cash transfers and parenting, which also involves extensive data collection on household consumption, time use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimizing Energy Efficiency with PCM Integration in Portuguese Residences' under Horizon Europe.

assistant: **Concept**

This research proposal pioneers energy-efficient residential structures through strategic integration of Phase-Change Materials (PCMs) into building walls. Focused on Portugal and the EU, the study targets substantial energy savings, initially estimated at under 18% based on pilot studies.Lightweight residential constructions emerge as pivotal, aligning seamlessly with Portugal's climate. Their swift integration allows for efficient temperature regulation, yielding substantial energy conservation. Economic viability, construction flexibility, and swift integration underscore the appeal of lightweight constructions for PCM adoption, addressing new projects and retrofits, aligning with regulatory and economic considerations.Empirical validation of meticulous simulation models forms the bedrock, ensuring practical applicability. Building energy modeling, integral to this research, plays a pivotal role in gauging real-world impact. This research proposal aligns global concerns: energy efficiency and sustainability. PCM integration, pivotal in sustainable building practices, offers an innovative solution. Exploration of PCM integration challenges further extends impact.In conclusion, this blueprint pioneers PCM integration, charting a course towards energy efficiency and sustainability. Attuned to Portugal's climate, it holds promise for wider global application. Validation experiments provide concrete evidence of potential energy savings and advancements in thermal performance, substantiating the proposal's potential impact.


**Keywords:** PCM Integration, Energy Efficiency, Residential Buildings, Sustainable Construction, Portugal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Validity of Different Survey Methods to Measure Risk Behaviour for Hiv the Sti - Comparison of Self-Reports the Biomedical Data' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The proposed study draws data from an ongoing European Commission DG XII funded cohort study entitled:  Behavioural, immunological and virology correlates of HIV-1 infection and super infection in rural Tanzania" The applicant was responsible for setting up an open cohort of 600 female bar workers who are seen on a three- monthly basis over three years creating data on about 7000 separate contacts. Follow up was 85% after one and a half years of the study and HIV and STI incidences remained high. Data collection for the proposed study will be completed by the start of the fellowship. The overall objective of the proposed research combining social science with medicine in a multidisciplinary approach is to contribute to the development of reliable and valid monitoring tools for measuring risk behaviours influencing the transmission of HIV and STI. The specific objectives and methods are the following:1. To analyse HIV, STI and socio-behavioural data of the high-risk cohort using appropriate statistical techniques.2. To compare different methods for self-reported risk behaviour (face-to-face reports, self-administered questionnaires and diaries) through comparison of reliability of answers in different formats.3. To validate self reported risk behaviour against biomarkers for STI (Gonorrhoea, Chlamydeous, Trichomonas, Syphilis), HIV, HSV-2, pregnancy and sperm through cross-tabulation of selected self-reported risk factors with biomarkers.4. To test the most reliable methods for obtaining self-reported risk behaviour in an existing general population cohort, and to investigate feasibility and usefulness of biomarker checks in this setting. The European Community funds several research studies within the INCO Programme and intervention programmes within its HIV/AIDS progra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Feeling with Light – Development of a multimodal optofluidic platform for high-content blood cell analysis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The reliable characterization of heterogeneous cell populations is a central prerequisite in many areas of medicine, biology, and biotechnology. Conventional techniques used for this purpose are either high-throughput, such as fluorescence-activated cell sorting (FACS), but limited to a small number of parameters or high-content, such as slide-based imaging approaches, which require surface attachment and preclude cell sorting. It is the overall objective of this proposal to develop a multimodal, microfluidic, laser trap-assisted cell screening platform technology – µFLAX – for the contact-free manipulation and high-content screening of suspended cells with high-throughput. Our approach is especially designed for blood cells, which will be serially trapped from microfluidic flow with a dual-beam trap. In addition to the extraction of molecular information (similar to FACS), we also incorporate mechanical phenotyping as a powerful new functional cell marker. In addition to looking, we can feel for functional changes using optically induced forces. This will be further augmented by structural analysis using digital holographic microscopy, cell size analysis using an optical cell rotator, and biological stimulation by microfluidic delivery of biochemical agents. This combination will offer much higher sensitivity and specificity in determining functional states compared to currently available techniques. And since the cells are suspended they can be sorted and analyzed further, which will aid potential molecular target identification. Once developed, we will demonstrate the applicability of µFLAX for the investigation and diagnosis of inflammation and infection. Based on our track record in pioneering innovative physical solutions to biomedical problems we anticipate that