RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The eBusiness research by Euro-Asian exchange programme' (EBEREA).

assistant: **Concept**

The eBEREA aims to set up a thematic joint exchange programme dedicated to advance research and higher education in the fields of electronic business (eBusiness) in EU and China. The programme will reinforce existing research collaboration through seconding and hosting researchers. The aim is to actively transfer knowledge with a view to generating strategic impacts in the thematic research area as well as developing sustainable collaboration between EU and China in research and in education.The thematic focus of this exchange programme is electronic business, more specifically business modelling and design; related financial services for consumers and citizens; and the institutional arrangements such as regulation and trust enhancing mechanisms on advocating the aforementioned topics for prospering eSociety.In China, electronic commerce/business is one of the key areas in long-term development of science and technology (S&T). Its importance is continuously increasing and the challenges and emergent issues in codes of conduct, financing, and legislation are recognised. Therefore the S&T responsible researchers in the fields of eBusiness in China are keen to exchange knowledge with their colleagues in Europe.For Europe, the research collaboration with China provides a new opportunity to study eBusiness of high volumes and high growth rates: the largest and busiest eBusiness sites in the world are Chinese. The decisions made by Chinese authorities and economic players regarding regulation and trust enhancing mechanisms are of global importance and crucial to the development of global eBusiness environment.eBEREA cooperation with the key developers of Chinese eBusiness and financial education gives an opportunity for the European partners to influence the development of eB
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Supporting Cyberinsurance from a  Behavioural Choice Perspective'.

assistant: **Concept**

CYBECO will research, develop, demonstrate, evaluate and exploit a new framework for managing cybersecurity risks, one that is focusing on cyberinsurance, as key risk management treatment. CYBECO integrates multidisciplinary research methods from Behavioural Economics, Statistics, Game and Decision Theory, Security Engineering and Behavioral Psychology in order to develop new concepts and models that are combined within a prototype software architecture (CYBECO Toolbox 2.0). CYBECO recognizes that the cyberinsurance domain is not adequately developed, partly due to the lack of sufficiently large statistical data sample and partly due to the difficulties customers face when deciding on their cyberinsurance investment options. CYBECO will address both these barriers, aiming at delivering advances clearly positioned beyond the State-of-the-Art. We plan to implement a prototype tool that will demonstrate and promote the CYBECO model and concepts. We then foresee to perform behavioural experiments to validate current institutional cybersecurity frameworks and to provide relevant policy insights, particularly in reference to behavioural nudges in cybersecurity. The CYBECO consortium is composed by complementary partners, coming from the addressed research, technological and market domains, that have a proven track record of high quality research capacity. Thus, the carefully structured workplan, embodies a holistic approach towards meeting the CYBECO objectives and delivering market-relevant outcomes of significant exploitation potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Engineering the Origin of Human Shape: Defining Patterns and Axes in the Early Stage of 3D Pluripotency', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

How an organism takes shape is a longstanding challenHow an organism takes shape is a longstanding challenge in modern biology and medicine. Understanding how, during the 3D embryo development, different molecular players, such as genetic programs, morphogens, and forces work together to build the shape of the body is still far to be understood, especially for humans. In recent years, some progress has been made to understand the inaccessible state of human development through models of human embryos derived from pluripotent stem cells. Although they brought very exciting findings, this approach failed in reconstructing the dynamic of the proper axes formation and 3D spatially ordered structure of tissues.  OriSha will provide a ground-breaking technology to control over time and space the early stage of human shaping by modulating in an in vitro model the biochemical and biophysical properties of the microenvironment. I will develop a hydrogel-microfluidic system to accurately and dynamically deliver liquid instructive signals coupled with 3D shape-controlled organoid technology to guide the geometry during morphogenesis and recapitulate the very early and inaccessible stages of human embryo development.  With this technological approach, I will instruct gradients of signalling molecules by imposing morphogens into the targeted tissues with unprecedented temporal and spatial resolution. To demonstrate the unique potential of this approach I will focus my interest on the development and morphogenesis of the neural tube that is the primordium of the central nervous system. Thanks to my cutting-edge approach, for the first time I will have the opportunity to investigate the correlation between the spatio-temporal dynamics and the 3D tissue patterning and self-organization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Incorporating real-life clinical data into drug development' (GETREAL), addressing dissemination and exploitation.

assistant: **Impact**

When a new medicine reaches the market, it is accompanied by an extensive data package that provides information about the safety and efficacy of the medicine in a clinical trial setting. However, assessing the expected future value of the medicines when used in “real world” clinical practice requires additional information next to traditional (pre-authorisation) clinical trials.  Regulatory, HTA agencies and other healthcare decision makers have to make decisions on authorisation and access under conditions of uncertainty.  Currently, data packages which aim to minimise uncertainty on safety and efficacy may leave significant uncertainty in assessments of real world effectiveness of new medicines.  This results in further research commitments required post-authorisation (PASS, PAES, Reimbursement with Evidence Generation), and wide variability in access to medicines between countries. The subsequent uncertainty relating to the reimbursement, and thus market implementation of new medication once approved by regulatory authorities, is negatively affecting the value of the drug development pipeline. The costly clinical developments to get to market approval, no longer seem to be a guarantee for market entry. This new risk presents a serious additional hurdle for drug developers that already face pipeline attrition. It also affects the speed and level of patient access, and therefore the extent to which patients and society might benefit from new medicines. In recent years there has been considerable attention paid to the post-authorisation evaluation of treatments in real world clinical practice: study design and analytical methodology for assessing relative effectiveness; and use of registries and electronic healthcare data.  It may be possible to improve the value of in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Optimising cancer therapy scheduling through personalised mechanistic models and reinforcement learning'.

assistant: **Innovation**

Cancers are complex, continuously evolving diseases unique to each individual patient. Yet, most drugs are administered according to fixed, “one-size-fits-all” strategies that always aim to deliver the maximum tolerated dose until it fails due to toxicity or resistance. “Adaptive Cancer Therapy” (AT) is a novel approach which seeks to delay drug resistance by personalising when and how much drug is given, based on the tumour’s response dynamics. After initial success in prostate cancer, there are now important questions about which patients would benefit from AT, and how should we optimally adapt therapy? In this 2-year fellowship, I will develop a computational framework to: i) understand and track resistance evolution from a patient’s tumour burden data (volume, blood biomarkers, ctDNA), and ii) translate this knowledge into personalised dosing strategies to slow resistance evolution and improve quality-of-life. To predict whether a patient will benefit from AT we need a firm, quantitative understanding of the dynamics of resistance evolution. Under supervision of Prof Trevor Graham at the ICR, I will develop a software package (B-REDi) which integrates a family of mathematical models and Bayesian inference to learn about the evolutionary route to resistance in a patient. Subsequently, I will deploy this package to investigate how AT is altering resistance evolution in a clinical trial in ovarian cancer (ACTOv). Finally, I will use deep reinforcement learning to explore how our calibrated models can guide treatment decisions even under uncertainty about resistance mechanisms. In the future, I plan to establish my own lab to develop computational tools to mitigate resistance and toxicity through schedule personalisation. This project will serve me as a steppingstone to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Glycosaminoglycans and their oligosaccharides derivatives : new opportunities in drug discovery.' to be submitted under Fifth Framework.

assistant: **Abstract**

The Glycosaminoglycans are biological polymers, which plays key roles in numerous biological processes. Glycosaminoglycan is mainly represented by heparin, heparan sulfate, chondoitins ABC and hyaluronic acid. Their structural heterogeneity and complexity is mainly linked to their sulfation degree. From basic disaccharide repeating units to highly complex disaccharide arrangement in the heparin backbone, a world of infinite structural diversity and oligosaccharide sequence is encompassed. The most fascinating is undoubtedly heparin. Through a specific interaction with antithrombine III, this polysaccharide is able to inhibit proteases involved in coagulation cascade. However, heparin is also able to interact with many proteins and its now obvious that particular sequences mediates other biological process than haemostasis (i.e. angiogenesis). For example, heparin discrete domains promote or inhibit cells proliferation through FGFs interaction. Again, other parts of the macromolecule are able to inhibit so-called inflammatory processes. Our goal is to disconnect the different biological properties of heparin by synthesizing specific oligosaccharidic sequences. This concept is extended to the other GAGs like chondroitins. The postdoctoral fellows will have to address GAGs specific issues in hemi-synthesis / total synthesis in other to prepare the targeted oligosaccharides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cost-Efficient Network for the Genetic Certification of Food Quality'.

assistant: **Objectives**

SeQfood project aims to provide the first tool for verifiable product authenticity certification and traceability along the food chain; also being the first electronic network for the genetic certification of food products. The invention relies on our proprietary Genowas-GENOMID fingerprinting technology, a smart system for agrifood certification and labeling by means of 2DNA codes which provide reliable, unique and forgery-proof information of identity, composition and geographical origin. Product´s information will be freely available in the SeQfood web, increasing transparency and consumer´s confidence. SeQfood will result on added value for high-quality products, but also simplifying logistics and traceability. Another powerful novelty is that costs and delivery time are comparable to PCR techniques but our solution provides greater information in a one-step assay. SeQfood represents an essential pillar for the company´s growth since by its commercialization the company will be able to penetrate the growing food traceability market and consolidate its position in the fields of genomics, proteomics and metabolomics. To ensure the successful market launch, our company will conduct a robust feasibility study and a business plan where main technical, commercial and financial resources and requirements will be deeply analyzed. SeQfood is in line with one of the present Societal Challenges of the European Commission addressing “Sustainable and competitive agri-food sector for a safe and healthy diet”, since it will serve as the first verifiable, standardized and free-access tool for warranting food safety, quality and traceability from production to consumption, and vice verse. This will improve food fraud prevention while also promoting high-quality authentic products, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Common molecular pathways in epithelial-mesenchymal transition and left-right asymmetries' (EMTASY), addressing dissemination and exploitation.

assistant: **Impact**

The majority of animals show an external bilateral symmetry, precluding the observation of multiple internal left-right (L/R) asymmetries which are fundamental for organ packaging and function. A prominent molecular pathway converging on and downstream of the Pitx2 transcription factor confers left-handed information in the left side of the embryo, with players expressed on the right ensuring that the left determinants are excluded. Therefore, conferring or excluding left identity in left and right hand sides, respectively, drives L/R asymmetry. Some indications suggest that a program actively specifying right–handed information could exist on the right. Our recent findings support this view. In a screening for novel regulators of the epithelial to mesenchymal transition (EMT), we have identified a transcription factor, EMT2, which similarly to well known factor Snail, it is an EMT inducer. The EMT is crucial for the development of tissues during embryonic development and for the progression of carcinomas to the invasive state. Strikingly, again as Snail, in addition to promote EMT, the EMT2 factor is predominantly expressed on the right side and may operate instructing L/R identity on the right-hand side of the embryo.With this background, our knowledge of the EMT and a series of genome-wide high-throughput approaches and a comprehensive functional analysis using the chick, the fish and the mouse as model systems we propose to reveal the putative molecular pathways conveying right-handed information and to reveal commonalities between L/R pathways and the EMT. In the long run, we aim at better understanding human pathologies that involve these morphogenetic and cellular processes, including pathological situs conditions (i.e. altered organ positioning) and cancer progr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A woman's reproductive experience: Long-term implications for chronic disease and death'.

assistant: **Objectives**

Pregnancy complications such as preeclampsia and preterm birth are known to affect infant health, but their influence on mothers long-term health is not well understood. Most previous studies are seriously limited by their reliance on information from the first pregnancy. Often they lack the data to study womens complete reproductive histories. Without a complete reproductive history, the relationship between pregnancy complications and womens long-term health cannot be reliably studied. The Medical Birth Registry of Norway, covering all births from 1967-, includes information on more than 3 million births and 1.5 million sibships. Linking this to population based death and cancer registries provides a worldwide unique source of population-based data which can be analysed to identify heterogeneities in risk by lifetime parity and the cumulative experience of pregnancy complications. Having worked in this field of research for many years, I see many erroneous conclusions in studies based on insufficient data. For instance, both after preeclampsia and after a stillbirth, the high risk of heart disease observed in one-child mothers is strongly attenuated in women with subsequent pregnancies. I will study different patterns of pregnancy complications that occur alone or in combination across pregnancies, and analyse their associations with cause specific maternal mortality. Using this unique methodology, I will challenge the idea that placental dysfunction is the origin of preeclampsia and test the hypothesis that pregnancy complications may cause direct long-term effects on maternal health. The findings of this research have the potential to advance our understanding of how pregnancy complications affect the long-term maternal health and help to develop more effective chro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Contextual Requirements Elicitation for Mobile Social Software'.

assistant: **Objectives**

The proposed research is in the field of requirements engineering (RE) and supports requirements discovery for mobile social software - an emerging and exciting phenomenon in today’s software and business world. Social software is currently weaving into the fabric of daily life faster than expected and enables its users to communicate, interact, and share data with other individuals. Two famous examples of social software include Facebook and YouTube. Emerging trends within social software include: the provision of social software for mobile devices, the integration of location-based services into social software, and the integration of social software and service-centric systems. Addressing these trends and the unique nature of mobile social software will require manifold research on mobile social software engineering. The goal of the proposed project is to develop and evaluate a tool-supported requirements discovery method tailored to the needs of mobile social software. It is planned that this method will support analysts in thoroughly understanding the needs of social communities and the patterns of communication and interaction within social networks. Firstly, this method will support on-site analysts in identifying and modelling social context information relevant to early design processes in addition to gathering system requirements. Secondly, the envisioned method will make use of the contextual information to enrich requirements discovery. It is expected that such context-enriched discovery will enable analysts to gather more and more accurate requirements for mobile social software systems. The proposed research will be conducted at the Centre for Human Computer Interaction Design at the City University London, a world-leading institution in the field of RE an