RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modelling latent causes in molecular networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In systems biology, we aim at deriving gene-regulatory or signaling models based on multivariate readouts, thereby generating predictions for novel experiments. However any model only approximates reality, leaving out details or other types of regulation. Here I ask why a given model fails to predict a set of observations with acceptable accuracy and how to refine the model using this experimental knowledge. This resembles a question from signal processing, namely the blind identification of hidden (latent) variables in a mixing model. Many, powerful methods have been proposed to answer it. However, they have not been extended to dynamical systems due to the involved strong nonlinearities.I propose to infer additional upstream species in a given model, denoted as latent causes, that improve the prediction and at the same time are subject to the model dynamics. Multiple causes are estimated using statistical assumptions such as minimum mutual information. The model estimation will be performed within a Bayesian framework. This will allow for the efficient but crucial inclusion of prior biological information. The method will be applied to infer a differentiation model describing lineage segregation of embryonic stem (ES) cells to endo- and mesoderm. Here, latent causes are known to be transcription factors and microRNAs, but also small molecules/drugs. Identified off-target effects of these causes will be validated in collaboration with experimental partners.This study will establish links between information-theoretic signal processing and dynamical systems. Its application to a detailed ES cell model will foster our understanding of differentiation and may ultimately contribute to the development of more efficient differentiation protocols for cell replacement therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coloured collector facades for solar heating systems and building insulation (COLOURFACE)' (COLOURFACE).

assistant: **Innovation**

Objectives and problems to be solved :A set of aesthetically-coloured thickness-insensitive spectrally selective solar absorber paints based on environmentally friendly binder and pigment systems suited for glazed solar facade collectors, which could be produced by respective SME-companies and applied by collector manufacturers by spraying or brushing in the workshop or at the building itself. Guidelines for the application of solar facade collectors as part of the building envelope based on experimentally validated studies of their energetic performance, architectural appearance and impact on the building physics. The promotion of the increased use of solar thermal energy by solar facades applied to combined domestic hot water and space-heating systems. Description of the work: Thickness-insensitive selective solar paints will be formulated with proposed coloured pigments (black spinel, graphite, coloured pigment), pigments with a low thermal emittance (SnO2:Sb, Al flakes, graphite, oxide coated Al flakes) and acrylic or polysiloxane binder system and optimised with respect to the compatibility of pigments with the binder systems and their optical properties. A solar absorptance above 80% (black absorbers are in the range between 90% and 95%) and a thermal emittance below 50% is acceptable because of the need to achieve well-acknowledged aesthetics of the coating. A compromise between the price of the pigments in these paints and the achieved optical selective properties will be evaluated. A suitable accelerated durability test methodology will be developed on the base of the test methods for solar absorber coatings developed by the Solar Heating and Cooling Programme of the International Energy Agency, and applied to the coatings developed within this project. Questio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neuroprosthetic Modulation of Large-Scale Brain Networks for Treating Memory Disorders' (MEMOPROSTHETICS).

assistant: **Concept**

Cognitive deficits caused by ageing, neurodegenerative diseases or brain injury represent a major public health issue. They are associated with a disruption of neural oscillations in large-scale brain networks, which cannot be restored using current treatments. Here, I propose a new neuromodulation framework for manipulating neural oscillations across large-scale brain networks to improve learning and memory. Specifically, I will create a large-scale neuroprosthesis of the hippocampus-prefrontal cortex circuit, which will simultaneously record and stimulate electrically key areas of the episodic memory network. I hypothesize that spatially, spectrally and temporally specific stimulation protocols within this network will enhance the functional interactions between hippocampus and prefrontal cortex, and will improve learning and memory. This conceptual approach will be evaluated in non-human primates trained on a visuospatial learning task.First, I will combine an electrocorticographic grid over the prefrontal cortex with depth macroelectrodes in the hippocampus and entorhinal cortex to create a novel large-scale brain implant. I will use this device to investigate the neural signatures of successful vs failed trials. Next, I will optimize electrical stimulation protocols that replicate successful neural signatures, and will test whether they improve memory in healthy animals. Third, I will induce temporary cognitive deficits in the animals using a cholinergic antagonist, and will assess the effects of stimulation in this pharmacological model of dementia. Finally, I will evaluate the chronic feasibility of this approach by translating these concepts into a fully implantable and wireless platform suited for future clinical applications. MEMOPROSTHETICS will lead to the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible and Adaptive Spoken Language and Multi-Modal Interfaces' (FASIL), addressing dissemination and exploitation.

assistant: **Impact**

We propose a robust and scalable Virtual Personal Assistant within the domain of conversational interaction, incorporating multi-modal input and output in a mobile device with access to an agenda, email and contacts and the potential for rapid integration of other Internet content. The system will be ideal for a 3G mobile network. The development of current and new research is required to generate adequate language recognition models for non-trivial domains and the fusion of multi-modal information with dynamically updated databases (to feed a mobile 3G service). This project deploys new research in natural language understanding, specifically:(1) Sophisticated dialogue management that adapts to the experience and style of the user; and(2) An advanced language model capable of integrating and unifying several models of linguistic knowledge.OBJECTIVESMobile phones have now almost saturated the market of major states of the EU; any further commercial advance must therefore come from developments in applications available on the ubiquitous hardware. In this proposal, we shall assemble a robust and scalable Virtual Personal Assistant managing e-mail, calendar and agenda through an intelligent, friendly adaptive multi-modal interaction. The project will use best-of-breed technologies for those modules of a multi-modal system that have matured, and deploy research to develop advanced language understanding and dialogue models. The innovation of FASiL is to pilot a full multi-modal voice portal application that is 3G mobile network ready, along with tools for rapid development of new applications. FASiL targets the languages of UK English, Portuguese and Swedish.DESCRIPTION OF WORKFASiL was prepared on an exploratory award grant and responds to key action line VIII.1.11. FASiL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Comparative analysis of risk governance for radiological and chemical discharges of industrial installations', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Aiming at improving the governance systems in radiological risks related to environmental radioactive discharges from nuclear installations, RISKGOV will carry out in-depth case studies in three countries (France, Sweden and United Kingdom) in order to analyse the key elements contributing to the quality of governance systems of radiological risks.These elements will be compared with those contributing to the quality of governance systems for chemical risks associated with environmental discharges from non-nuclear installations. For this purpose, an interdisciplinary analysis framework addressing the role of the key stakeholders within the governance systems will be prepared. The assessment of the governance systems will aim at drawing out lessons and operational recommendations on how the governance systems at EU levels could be improved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'innovative Energy Storage TEchnologies TOwards increased Renewables integration and Efficient Operation'.

assistant: **Innovation**

i-STENTORE will examine the integration of diverse storage solutions and their combinations. Innovative storage systems will be showcased and their co-operation with the integrated assets will be co-optimized, placing the reliability, the power quality, the cost-efficient operation and the maximization of the assets’ lifetime as end-goals. i-STENTORE will introduce an umbrella framework aiming to showcase stand-alone and hybrid storage solutions highlighting the multi-purpose use of storage, not only as an energy buffer, but also as an active grid component capable of providing services and contributing to grid resilience, stability and efficient operation. The proposed framework will examine the applicability of versatile storage solutions in various applications covering the mobility, agricultural, industry, household, heating and other sectors, and in different timeframes, creating what-if scenarios for the selection of the optimal storage solutions to serve each individual application in the most effective way, promoting purpose-specific Hybrid Energy Storage Systems (HESS). To achieve this and to ensure a seamless integration in a technology-agnostic and interoperable manner, i-STENTORE will design a Reference Architecture towards an open and flexible storage-enabling European energy system leveraging storage-induced flexibility and facilitating the increased integration of renewable energy sources (RES). i-STENTORE will embrace the introduction of novel business models, towards building positive and attractive business cases for storage, identifying new revenue streams for storage operators and promoting storage systems as a facilitator of the energy transition. This approach will develop and validate the enhanced connectivity of multiple systems at different leve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Research Area - Canada Information and Support Service' to be submitted under Seventh Framework.

assistant: **Abstract**

ERA-Can II aims to increase opportunities for cooperation and greater coordination between Canadian and European researchers in areas of common priority by improving the level of knowledge, quality of strategic information and practical assistance available to Canadian policy-makers, researchers and research managers on FP7 programs, networking tools and research activities. To that end, it adopts a strategic approach that: (a)· complements, through close collaboration, the efforts of federal, provincial and private sector research funding agencies, organizations and networks in Canada and the work of the European Commission, trans-national, national and private sector research funding agencies, organizations and networks in Europe; (b) focuses on areas and sub-areas of strategic importance to Canada, Canadian stakeholders and the European Commission; (c) builds on the successes and lessons learned from past and continuing initiatives. It applies this approach in pursuing the following strategic objectives: (1) improving the processes for obtaining timely strategic information on FP7 programs, networking tools and activities, in areas of common priority, for Canadian policy makers, researchers and research managers; (2) improving the processes for providing timely strategic information and practical assistance to Canadian policy-makers, researchers and research managers that encourages and facilitates international coordination for policy-makers and the participation of researchers and research managers in FP7 programs, networking tools and activities in areas of common priority; (3) improving Canadian and European knowledge of Canada-Europe S&T cooperation, identifying issues and advancing best practices in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COmbined Spectroscopy and Molecular-scale Imaging of Conjugated polymers' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

COSMIC is an ambitious research project aimed at addressing a critical challenge in organic photovoltaics (OPVs), particularly their long-term stability, which is essential for enhancing their contribution to renewable energy solutions and tackling climate change. OPVs, which are lightweight, flexible, and can be integrated into a wide range of applications—from building-integrated photovoltaics to solar-powered greenhouses and aerospace technologies—represent a promising alternative to traditional silicon-based solar panels. However, despite recent advancements, OPVs face performance degradation over time due to the instability of their active materials.The central focus of COSMIC is to gain unprecedented molecular-level insights into the microstructure of conjugated block copolymers, a key class of materials recently proposed in OPVs to tackle the stability problem. These materials combine electron donor and acceptor molecules into a single polymer chain, a design with great potential for enhancing OPV performance. However, the precise arrangement and interaction of D and A units at the molecular level are still not fully understood, limiting further advancements.COSMIC will employ cutting-edge techniques such as scanning tunnelling microscopy and photoemission spectroscopy to study the molecular structure, assembly, and electronic properties of these materials with unprecedented resolution. The project is structured around three core objectives: characterising the molecular-scale structure and electronic properties of PM6/Y6 and PM6-b-Y6 polymers at the molecular level, correlating these insights with OPV device performance, and feeding this knowledge back into the synthesis process to enable optimisation through rational design.The outcomes of COSMIC are expected to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microbial Commons: Building a legal instrument for farmers' rights on agricultural microbial resources' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Farm management practices have been shown to drive the evolution of specific consortia of agricultural microbial resources that contribute to increased agricultural productivity. The ecological traits of agricultural micro-organisms have made them an important target for patenting. Farmers' rights are an outcome of the recognition of the role of farmer communities in the evolution of crop varieties. Indigenous farmers have acted as selection agents in the development of crop as well as agricultural microbial resources by increasing reproductive fitness of particular genotypes. However, unlike with crop selection, no formal recognition of farmers' rights or potential benefit sharing programme has been proposed for agricultural micro-organisms that evolved from farming regimes. The central thesis that this project seeks to prove is that multilateral trade and environmental agreements  have failed in protecting the rights of indigenous farmers for their intellectual contribution in selection of beneficial agricultural biodiversity. The coming into force of TRIPS agreement and the Convention on Biological diversity has concretized the patenting regime of micro-organisms. In the absence of effective international and national legal enforcement, benefits are shared through mutually agreed contract arrangements which are invariably skewed against indigenous farmers. A commons approach to micro-organisms has potential to align farmers' rights on agricultural microbial resources with legal instruments developed for plant genetic resource collections. Microbial commons is conceptualized and builds on other work that is done in the areas of genetic resource commons and networked information commons in digitized environments in the field of genetic resources. This project aims to a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Linking the intrinsic protein dynamics to function in glutamate transporters'.

assistant: **Concept**

The alternating access model of how membrane-embedded transport proteins translocate substrates across biological membranes has been proposed since the 1960s: membrane transporters bind substrates on one side of the membrane and release them on the other side upon conformational rearrangements in the protein. This has been experimentally confirmed by high-resolution structures of membrane transporters in different conformations and is exemplified by the conformational change in the archaeal glutamate transporter homologue GltPh from Pyrococcus horikoshii. GltPh is a trimer in which each protomer functions independently of the others. Outward and inward facing conformations suggest transport by alternating access to either side of the membrane whereby a distinct transport domain undergoes large rotational and translational movements relative to the static trimerisation domain. It is unknown how GltPh achieves this conformational rearrangement, which occurs both in the absence and presence of substrates. We propose to integrate cutting-edge techniques in membrane structural biology to identify dynamic hotspots that drive the large conformational transitions in GltPh. We will combine insights from protein crystallography with local variations of thermodynamic stability and protein dynamics measured by hydrogen/deuterium exchange to map the structural components that allow conformational change to occur. In doing so, we will obtain new insights into how GltPh functions, shedding light on the mechanism of biomedically important glutamate transporters. We will use this model system to develop strategies that allow understanding of the molecular basis of substrate transport. The methods developed would be widely applicable to other membrane transport proteins.


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