RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Doxorubicin-induced impairment of metabolic and stress signaling: a culprit of cardiotoxic action of the drug?' under Seventh Framework.

assistant: **Concept**

Anthracyclines, in particular doxorubicin, are the most effective anticancer drugs. However, their serious side effect is a cardiotoxicity, which is not entirely understood. We propose a novel hypothesis, namely that anthracycline-induced cardiac damage is related to impaired cellular responses to energy depletion, and possibly also to other forms of stress (oxidative, genotoxic), inducing a “catastrophe”, fatal for cardiac (and cancer) cells. The aim of the project is to verify this hypothesis in different models: perfused heart, cultured cardiomyocytes, and an in vivo model of cardiotoxicity newly established in our group, the doxorubicin-treated rat. Our project will integrate: (i) a non-biased phosphoproteomic approach extending our transcriptomic study and aiming at the identification of new phosphorylation events mediating response to doxorubicin; (ii) a targeted approach focusing on pathways identified by our targeted and non-biased in vitro studies, as e.g. signaling by LKB1-AMPK-mTOR, MAPK, HIF, VEGF, and NDPK, a metabolic kinase that we have recently identified as doxorubicin target. We will analyse the effects of doxorubicin on these pathways (including gene and protein expression, phosphorylation, activity) and their consequences for cardiac function, energy state, apoptotic status, and response to an additional stress (ischemia). This multidisciplinary project will combine biophysical, biochemical, molecular, physiological and systems biology (phosphoproteomics, modeling) state-of-the-art approaches. We expect to identify new signaling pathways mediating doxorubicin cardiotoxic action. Further integration of the fellow with the host will allow full valorisation of projects initiated during the present Marie-Curie Fellowship, further supervision of PhD and m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated microfluidic phage display through non-fouling droplet-based technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Effective diagnostic technologies are essential for mitigating the devastating impact that infectious disease has on society. The identification of ligands that can target infectious disease biomarkers within patient samples is key to the function of modern diagnostics. Unfortunately, current methods for ligand selection are slow and labour intensive, and frequently hinder the development of diagnostic technologies. Novel methods for automating this process will increase efficiency and improve the capacity of communities to respond to outbreaks and epidemics. During this fellowship I will develop a novel microfluidic device capable of automated high-throughput selection of highly robust infectious disease targeting ligands. The main objectives are as follows: 1) Explore novel microfluidic materials that are compatible with common ligand selection work flows; 2) Develop a fully automated microfluidic platform capable of performing multiple rounds of ligand selection; 3) Apply this system to generate novel ligands against an emerging HIV biomarker. The device will be underpinned by multiple core microfluidic technologies developed within the host lab, including: rapid droplet generation, droplet disruption, non-fouling materials, and highly responsive microvalves. These technologies will be combined with my expertise in protein chemistry, protein engineering, and chemical biology to achieve a significant leap forwards in automated ligand selection. The resultant device will vastly increase accessibility to high-throughput ligand selection, enabling smaller labs to more effectively select high-affinity ligands against emerging disease targets. This will have a significant impact on the fields of diagnostics, targeted therapeutics, protein engineering, and microfluidics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Production technology to achieve low Cost and Highly Efficient phOtovoltaic Perovskite Solar cells' (CHEOPS), addressing dissemination and exploitation.

assistant: **Impact**

The aim of CHEOPS is to develop very low-cost but highly performing photovoltaic (PV) devices based on the emerging perovskite (PK) technology. At lab scale (<0.5cm2), PK energy conversion was rapidly advanced to efficiencies >20%. But only few attempts at upscaling have been made, yielding significantly reduced efficiencies <9% on aperture area. In addition, the very question about material stability and reliable measurement procedures are still debated.CHEOPS will now scale up the lab results to single junction modules manufactured in a pre-production environment while maintaining high efficiencies (>14% stable for aperture area in modules >15x15cm2). This will demonstrate the potential of PK as a very low-cost technology (target <0.3€/Wp) well suited for building-integrated PV.In parallel, CHEOPS will develop materials and processes to achieve very high efficiency (>29% on 2x2cm2 cells) at low cost (target <0.4€/Wp) using a tandem configuration with a crystalline silicon heterojunction cell.CHEOPS will also perform a sustainability assessment from a life-cycle perspective to anticipate potential risks for the technology (including business, technological, environmental, social & political risks). CHEOPS will establish a quantified future development roadmap as well as protocols for stability testing and for reliable measurements.CHEOPS partners cover the whole value added chain: key PK researchers, groups with track records of scaling up high efficiency and tandem cell developments, specialised technology and service providers as well as SMEs and industry partners with already strong IP portfolios, ready to exploit the CHEOPS results. Transferring the results to other growing industry sectors such as lighting or organic large area electronics will additionally benefi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Advanced tools for integrated supply chain management in European SMEs'.

assistant: **Concept**

Studies have shown that a 10% reduction in supply-chain costs can result in a 30-50% increase in profit. This is partly due to the fact that in many cases, external spend can represent as much as 50-60% of a company's total revenues. This portion of an enterprise's resources is often managed by a supply chain that is fragmented, which often results in a system that is unresponsive, wasteful, and limited in efficiency. Increasingly, companies are being required to adapt to markets in which the customer pulls the product from the manufacturer often with very short lead times. The main innovative results set by CHAMAN are: - A cost-effective SME-oriented flexible supply chain logistics tool set capable of responding in real time to market changes. - A STEP-based data exchange framework that spans the total supply chain and provides the users with an open, integrative framework where other tools can be plugged in. The technology will be demonstrated through two practical and application-specific implementations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Citizen Attitudes Towards National and International Problems' under Horizon Europe.

assistant: **Concept**

Political scientists have collected rich data for understanding the preferences of citizens regarding which policies their governments ought to enact, as well as for investigating where these preferences do and do not exist, and how they arise. In contrast, we have poor data and methods for understanding which problems citizens think are most severe and which government policy should be urgently addressing.  These questions of problems and priorities are difficult to investigate because they are challenging to formulate in terms of closed-ended survey questions that yield cross-nationally and inter-temporally comparable data.  This project addresses this gap by using innovative techniques to measure citizens’ views about problem severity and priority.  The proposed applications, in turn, will push forward our understanding of how citizens understand what politics and policy-making are trying to achieve, how they interact with media information sources and their representatives, all of which are core concerns of the study of political behaviour and public opinion. This research would enable a major step forward in our understanding of several political science questions.  First, which people, in which countries, are relatively engaged with and prioritise global problems (e.g. international environmental, security, and economic issues) by comparison to more immediate local or national problems? Are views about political problems generally stable over time, at the level of individual citizens or at the level of populations?  Second, to what extent do major media sources and/or political actors set the problem agenda for citizens, versus responding to citizens’ existing problem agenda?  Third, what are the electoral implications of politicians and media emphasizing or de-em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New powertrain concept based on the integration of energy recovery, storage and re-use system with engine system and control strategies' under Seventh Framework.

assistant: **Concept**

High efficient energy conversion concept based on the integration of energy recovery devices, energy storage and engine auxiliaries electrification on a Natural Gas heavy duty engine.The energy recovery strategy is based on two mainstreams:• recovery of a portion of the kinetic energy thanks to the adoption of a belt driven generator• recovery of the waste heat with an energy cascading approach: thermoelectric generator operating at high temperature subsequent turbo-generatorThe system includes an appropriate energy storage system and electrified auxiliaries such as  coolant and oil pumps, auxiliary turbo charger, air and air conditioning compressors.The engine control strategies will be tuned and optimised (combustion, cylinder de-activation, …) to maximise the efficiency of the energy recovery and re-use subsystems and the benefit the auxiliaries electrification. Finally the combination of the electric auxiliary turbocharger and the abortion of a liquid cooled charge air cooler will be implemented as part of the whole strategy to optimise the engine efficiency.The Project results will be experimentally demonstrated at bench level (engine test rig) while the benefits of the engine down-sizing, combination of control strategies and the reference mission(s) and integration with hybrid or hybrid-like powertrains will be evaluated at vehicle level thanks to advanced dynamic models.The industrial feasibility, the portability on diesel engine and the cost estimation are also included in the as well as a preliminary packaging study to assure the on board integrability.The Project most important outcome will be a new powertrain concept based on a combined energy recovery, storage and re-use system integrated and optimised with the engine system and controls.The project will an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EU-India Innovation Center' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The challenge of transferring innovation from Europe to India has been a thorn in the side of establishing European presence in third countries and strengthening its position as a science, technology and innovation leader. Europe must take the lead in stimulating and enabling Europe-India interactions and mobilising the ecosystems to build bridges between the regions.The EU-India InnoCenter is brought to life to extend the network of centres in the world's most dynamic, innovative subcontinent by connecting and supporting European researchers and entrepreneurs to launch and expand their activities in India.•    The long-term strategic objective of the EU-India InnoCenter is to sustainably contribute to the establishment of Europe as a science, technology and innovation leader in India.•    The direct objective of the EU-India InnoCenter is to build a centre in India that will, in close cooperation with local technology and innovation structures, guide European innovators on their journey to soft-landing in India, stimulate constructive co-creation, build an ecosystem of stakeholders, and bolster a two-way technology and knowledge transfer.The project will support European startups and SMEs to enter India’s market with: •    35 internationalization bootcamps to consider India for expansion;•    920 hours of expert consultations to prepare localization strategies;•    8 vertical-specific market immersion programmes to find the first clients and partners;•    5 batches of a 3-month programme to help European technologies adapt and scale to the Indian market;•    Network of  30000+ Indian innovators through the consortium partners’ coworking hubs in nine major Indian cities.The consortium comprises leading startup support organizations covering most of Europe and India with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implementing product quality regulation', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Models of oligopolistic behavior that helps assessing the welfare effects of different instruments to implement quality standards. It shall be possible to show that sanctions like fines have different impact than product withdrawals both on precaution efforts by firms as well as on competitors ' profits. Entry, exit, and average quality and accordingly dependent upon the type of sanctions used.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MEsmerizing Thermal Annihilation Method to Obliterate Radicals PHOtoinduced in Substances for Increasing Spin polarization' (METAMORPHOSIS).

assistant: **Innovation**

The use of hyperpolarized 13C magnetic resonance (HP 13C MR) to perform radiological scans can provide novel information for medical diagnostic purpose. HP 13C-molecules are injected intravenously and allow performing metabolic imaging, highlighting diseased tissues and treatment response. HP 13C-urea is also a potential nontoxic alternative to gadolinium-based contrast agents for MRI. Hyperpolarization aims at dramatically increasing the 13C MR signal by dynamic nuclear polarization (DNP), which requires the use of free radicals. The presence of free radicals prevents the storage and transport of HP 13C-molecules which thus need to be prepared a few minutes prior to injection using hot water as dissolution medium. Within the framework of the ASSIMILES project, it was already demonstrated that by using photo-induced free radicals, HP 13C-molecules can be polarized and then extracted in the form of frozen solution following the annihilation of the free radicals.The aim of METAMORPHOSIS is to implement and commercialize devices compatible with the creation and annihilation of photo-induced free radicals in a controlled and reproducible manner, and that can be easily transferred in and out of a cryogenic environment. This innovation is expected to lead to a paradigm shift for 3 main reasons: (a) it will eliminate critical failures related to the dissolution process currently used to prepare doses of HP C-molecules for injection; (b) it will remove the need for synchronizing production and injection since doses can be polarized ahead of time; (c) it will become possible to place the polarizer in a remote location because doses can be stored and transported. The overall objective is to provide a complete solution to prepare and deliver HP 13C-molecules to MRI suites. Unlike
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Slavery, Abolition and Archipelagic Connections in the Swedish Caribbean' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Surveys and datasets of the trans-Atlantic slave trade do not include Swedish slave trade and colonial history. Yet, when Sweden acquired the Antillean island Saint Barthélemy in 1784 it became a slaving nation that traded and smuggled captive Africans and punished the enslaved population using draconic slave laws until the abolition of Swedish slavery in 1847. The project is the first investigation of new sources and it situates Swedish colonialism in the Caribbean archipelago. By shifting the emphasis of the previous historiography from the European colonizers to building knowledge on the enslaved and free Afro-Caribbean majority population the project shows how the Swedish Caribbean society only can be understood in a larger setting where single-nation historical narratives have little explanatory power. Five subprojects creates new knowledge that will build a critical mass of data on hitherto unstudied facets of Swedish Caribbean history: slave law and justice, slave trade, abolition of slavery, colonial demography, and colonial governance. The project uses the Swedish governmental colonial archive held in France that for the first time has been made accessible in the PI’s preceding project. By scholarly publications and the creation of datasets covering legislation, biographies of the majority Black population, slave trade data etc. – and publishing them online in both project-owned databases and by contributing to major international datasets – it develops new methods within digital Caribbean and colonial history. The Caribbean intergovernmental organization CARICOM has included Sweden in its claims for reparations for “genocide, slavery, slave trading, and racial apartheid” and the project builds a firm basis to evaluate Swedish participation in Caribbean slavery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid Integrated BIophotonic Sensors Created by Ultrafast laser Systems', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

A biochip is a device that squeezes the functionalities of a biological laboratory on a single substrate through a network of microfluidic channels, reservoirs, valves, pumps and micro-sensors. Its advantages are high sensitivity, speed of analysis, low sample consumption and measurement automation and standardization. This concept promises dramatic advances both in basic research and in clinical applications as a low-cost diagnostic tool.We propose the demonstration of a new technology, based on high intensity femtosecond laser pulses, providing an integrated platform for the fabrication of biochips with photonic functionalities. Such technology enables to include a network of femtosecond written optical waveguides on a standard biochip. The waveguides can be arranged in different configurations with respect to the microfluidic channels, exploiting the unique three-dimensional capabilities of the femtosecond writing technique, to implement photonic biosensors.An additional goal is the use of the femtosecond laser technology to directly write the microfluidic channels. If both goals are achieved, we can envisage a single production machine for the biophotonic chips, based on a high-power femtosecond laser, that can manufacture both the microfluidic channels and the optical waveguides.To achieve these goals we will demonstrate advanced diode-pumped femtosecond laser sources, with average power higher than currently available. These laser sources need to be sufficiently compact, reliable and user-friendly for industrial environment.The unique integration of photonics and microfluidics, enabled by the inscription of optical waveguides on the biochips, will allow to implement a wealth of novel biosensing functionalities. We concentrate on two prototypical devices, available