RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'European Study to Establish Biomarkers of Human Ageing'.

assistant: **Innovation**

The rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors. Age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Many candidate biomarkers have been proposed but in all cases their variability in cross-sectional studies is considerable, and therefore no single measurement has so far proven to yield a useful biomarker of ageing on its own, probably due to the multi-causal and multi-system nature of ageing. We propose to conduct a population study (3,300 probands) to identify a set biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any marker in isolation. Two large groups of subjects will be recruited, i.e. (1) randomly recruited age-stratified individuals from the general population covering the age range 35-74 years and (2) subjects born from a long-living parent belonging to a family with long living sibling(s) already recruited in the framework of the GEHA project. For genetic reasons such individuals (“GEHA offspring”) are expected to age at a slower rate. They will be recruited together with their spouses as controls, thus allowing initial validation of the biomarkers identified. (3) A small number of patients with progeroid syndromes will also be included in the study. A wide range of candidate biomarkers will be tested, including (a) “classical” ones for which data from several smaller studies have been published; (b) “new” ones, based on recent preliminary data, as well as (c) “novel” ones, based on recent research on mechanistic aspects of ageing, conducted by project particip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cellular cartography of the intestine in health and inflammation' (GUTMAPS).

assistant: **Innovation**

The intestinal epithelium is the first line of defence of the mucosal immune system because it acts as a dynamic physical barrier segregating the luminal content from the underlying mucosal tissue. This barrier is mainly formed by a monolayer of specialised intestinal epithelial cells (IECs) that are crucial in maintaining intestinal homeostasis. Damage to this epithelial layer can increase intestinal permeability and lead to abnormalities in interactions between IECs, stromal cells and immune cells in the underlying lamina propria thereby disturbing the intestinal immune homeostasis, all of which are a hallmark of several intestinal disorders including inflammatory bowel diseases (IBD). Ulcerative colitis (UC) and Crohn’s disease (CD) are the two major forms of IBD, affecting an estimated 4 million people in the United States and Europe and have a rising incidence in the developing world. Recent single cell RNA seq (scRNAseq) studies of the intestine have allowed us to understand this organ in unprecedented detail, however, such studies still require the dissociation of tissue and loss of spatial resolution. With this project, I would like to take advantage of recent advances in in-situ sequencing to study intestinal tissue in toto and by combining this with the available scRNA-seq data, generate spatial maps of the intestine (GUTMAPS). The results obtained here will allow us to look at tissue composition and cell-cell interactions with unprecedented resolution in normal and diseased mucosa.


**Keywords:** Inflammatory Bowel Diseases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'SPACEWIRE RT'.

assistant: **Objectives**

The trend towards “Operationally Responsive Space”, where spacecraft can be rapidly assembled, configured and deployed, to meet specific mission needs, e.g. disaster support, requires flexible on board communication networks with plug-and-play capability. The growing autonomy of scientific missions to remote planets requires networks that are robust and durable, able to recover from transitory errors and faults automatically. The importance of spacecraft mass reduction motivates the sharing of networks for payload data-handling and avionics. Avionics and robotics impose requirements on network responsiveness and determinism. Increasing international collaboration on scientific and Earth observation spacecraft requires standard network technology where a component developed by one nation will interoperate effectively with equipment developed by another. SpaceWire-RT aims to fulfil these demanding requirements with a flexible, robust, responsive, deterministic and durable standard network technology that is able to support both avionics and payload data-handling applications. SpaceWire is a very successful first step in this direction, providing networking technology for payload data-handling on over 30 major space missions. It falls short, however, of the requirements for avionics systems. A quality of service (QoS) layer is needed for SpaceWire to support mixed avionics and data-handling applications. SpaceWire-RT will: use virtual channels to provide a variety of QoS; provide broadcast and multicast capability; support extremely low latency time and out-of band signalling; and incorporate novel fault detection, isolation and recovery methods. The network will be fully responsible for information transfer, decoupling application and data transfer. Creation of this techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Policy-relevant models of the natural and anthropogenic dynamics of degradation and desertification and their spatio-temporal manifestations' (1994-1998).

assistant: **Innovation**

The project aims to contribute to the formulation of policies concerning land degradation, the effects of which are compatible with, and can safely and efficiently be applied to, a wide range of national, regional and local circumstances by investigating how the rapidly changing social and socio-natural dynamics of Souther Europe (urbanisation, agro-industry, infrastructure) relate to the problems of degradation and desertification in that area.The present project is the sequel to the investigation (ARCHAEOMEDES I) of the many temporal scales (from 106 to 10-1 years) involved, and will primarily be concerned with the spatial aspects of the dynamics. It focuses on (1) the definition of the various levels of structuration which drive the dynamics involved, (2) the investigation of the ways in which the dynamics at these various levels articulate, (3) the creation of decision-support models of these dynamics which facilitate the investigation of alternative scenarios for the future, and (4) the development of ways in which to map these dynamics in geographical time-space. Four scales will be studied, each representing the interaction between two levels of structuration : (1) the European and national scale (focus on overall population dynamics); (2) the regionalsubregional scale (focus on spatial structure of human settlement vs. that of the natural environment, to be investigated in the Lower Rhtne Valley, the Languedoc-Roussillon and the Midi-Pyrinees (France); (3) the subregional-local scale (focus on the immediate ways in which a population controls its interaction with the environment, which are constrained by perception, the nature and internal dynamics of the communities involved, the spatial structure of the resources and the settlement pattern, etc., to be investi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Micro- and nanotechnology in nuclear magnetic resonance' (2002-2006).

assistant: **Concept**

This proposal entails a post-doctoral project regarding the development and application of Micro- and Nanotechnology in Nuclear Magnetic Resonance (NMR) The focus is on high-resolution small-volume NMR spectroscopy and development of new scientific tools like miniaturized NMR, including the development of new techniques like small-volume hyphenated techniques as NMR-MS.The project comprises four main tasks, following the objectives:- Optimization and manufacturing of current NMR-on-a-Chip models, optimization of the NMR-chip, in particular regarding the materials to be used, the NMR coil design, the micro/nanofluidic systems and the optimal volume/signal-to-noise ratio.- Design, optimization and manufacturing of advanced NMR-on-a-Chip: the design and development of NMR chips for multinuclear experiments with multiple coils, either parallel or in series, the integration of a variable temperature system.- Testing of NMR chips with real reactions: testing of different reactions, screening of libraries of compounds in parallel microfluidic channels.- Design and development of Micro and Nano NMR-MS hyphenated techniques.The Micro and Nano NMR project fits very well within the scope of different strategic objectives of the 6th Framework European Programme (FP6). The development of new small-volume NMR techniques is a typical example of nanotechnology that can be applied to different fields, including life sciences. Indeed this project will obviously benefit any company in need of mass-limited samples.For example pharmaceutical companies looking for fast and cheap fabrication of screening of new medicinal compounds. Micro- and nanotechnology are currently among the most rapidly growing fields of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'People, objects and technologies at the interface – multiscalar interaction networks in the Aegean Bronze Age (3100-1200 BC)' (POTI), addressing dissemination and exploitation.

assistant: **Impact**

The aim of POTI is to investigate the relationship between people, objects and technologies at the interface of cultural encounters, and their role within multiscalar, diachronic interaction networks that characterise emerging complex social worlds within the Bronze Age Aegean (3100-1200 BC). The geographical setting of Aegean islands, with their connected seascapes and coastlines, offer a valuable arena for assessing the dynamics behind past cultural encounters and interaction networks. The primary training objective is to develop a diachronic approach for investigating material, technological and social interactions across multiple spatial scales. To achieve this, training in the application of broad comparative frameworks from island archaeology and Mediterranean network perspectives is needed to integrate the many interactions that constitute complex societies across multiple geographical and chronological horizons. By reassessing the rich assemblages and connections of the Bronze Age Aegean using this approach, cultural encounter interfaces for material culture change can be identified and characterised. Acquisition of GIS and multivariate statistical skills will enable the spatial and chronological mapping of these interfaces, which, anchored within theoretical frameworks of social vs. insular networks, will shed new light on these key arenas for understanding dynamic processes of social interaction, community participation and identity formation within the Bronze Age Aegean.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bacterial transport proteins - simulation studies of mechanism' (1998-2002) under Fifth Framework.

assistant: **Objectives**

I have known Marc BAADEN since 1994, the year he began his studies at the Ecole Européenne des Hautes Etudes des Industries Chimiques de Strasbourg, (now Ecole Européenne de Chimie, Polymères et Matériaux de Strasbourg, ECPM), where I teach Physical Chemistry. He was a brillant student and obtained his degree in 1997, placed first in a class of 63, the Giulio Natta" group. Since 1997, I have cosupervised his doctoral studies along with my colleague, Professor G. WIPFF. Marc BAADEN has all the necessary skills for research: ingenuity, creativity, thoughtfulness, an appetite for work, efficiency and good organisation. He has shown in practice the ability to conduct sophisticated theorectical and experimental studies at the same time. A post doctoral appointment at Oxford University will enable him to extend his mastery of molecular dynamics in the biological domain. I am sure he will carry out excellent work and that his host laboratory will quickly recognise him as a "remarkable post doc". I offer my strongest support to his application for a Marie Curie Award. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Platform for autonomous self-deploying and operation of wireless sensor-actuator networks cooperating with aerial objects' (AWARE) under Sixth Framework.

assistant: **Objectives**

The general objective of the project is the design, development and experimentation of a platform providing the middleware and the functionalities required for the cooperation among aerial flying objects, i.e. autonomous helicopters, and a ground sensor-actuator wireless network, including mobile nodes carried by people and vehicles. The platform will enable the operation in sites with difficult access and without communication infrastructure. Then, the project considers the self-deploying of the network by means of autonomous helicopters with the ability to transport and deploy loads (communication equipment and nodes of the ground network).To reach the above mentioned main goal, the project has the following technical objectives:1) Develop a scalable and self-organizing ground sensor network;2) Develop the architecture and middleware required for the cooperation of the heterogeneous objects including aerial vehicles, static sensor-actuator nodes, and mobile nodes carried by ground vehicles and people;3) Develop network-centric functionalities for the system operation, including the development of perception techniques and the reliable co-operation based on the explicit consideration of the main sources of failures in the network operation;4) Develop new cooperation techniques for tasks requiring strong interactions among vehicles and between vehicles and the environment, such as lifting and transporting the same load with several UAVs.In order to verify the success in reaching the objectives, the project considers the validation in two different applications: Filming dynamically evolving scenes with mobile objects, and Civil Security/Disaster Management. Three general experiments in a common scenario will be conducted in order to integrate the system and test the func
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INTEGRATION OF PLANT ORGANELLE COMMUNICATION UNDER ENVIRONMENTAL STRESS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Environmental challenges such as drought, temperature and light extremes can impose oxidative stress in multiple organelles, thus negatively affecting the function of plant cells. Both chloroplasts and mitochondria can invoke signaling pathways to the nucleus that trigger stress responses and adjustment of cellular homeostasis, resulting in physiological outcomes such as enhanced stress tolerance, or conversely programmed cell death. These pathways include the 3'-phosphoadenosine 5'-phosphate (PAP)-SAL1 pathway for chloroplasts and the ANAC013 mobile transcription factor for mitochondria. However, the mechanisms by which plant cells coordinate different signals from chloroplasts and mitochondria for whole-cell acclimation to oxidative stress are still enigmatic. Whether there is any cross-talk between chloroplast and mitochondrial signaling is also intriguing. My project will investigate these fundamental questions using an exemplar model system consisting of three components that combine my research with the Hosts’. The first goal is to take my PNAS findings that SAL1 is a redox-regulated initiator of chloroplast signaling and determine if a similar mechanism occurs in the mitochondria, where SAL1 is also localized. This would reveal how two distinct organelles can integrate oxidative stress sensing and response by using the same pathway. Second, the interaction between SAL1-redox sensing and the mitochondrial signaling transducer ANAC013 will be investigated to understand integration between these two apparently distinct pathways. Third, ANAC013 targets a biosynthetic enzyme for PAP hinting at crosstalk between mitochondrial and chloroplast signaling at the level of signal metabolism. Thus, my research on SAL1-PAP and VIB’s on ANAC013 collectively present a unique opp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'High integrity EGNSS Layer for Multimodal Eco-friendly Transportation' (HELMET) targeting Horizon 2020.

assistant: **Abstract**

The main objective of HELMET is to develop innovative EGNSS applications capable to impacting on eco-friendly and green transportations means. Target adopters of EGNOS and Galileo are the Connetcted and driverless cars, Train signaling, UAV for surveillance of roads and railways. Multi-modality is HEMET’s differentiator to federate innovative applications transforming the independent habit of roads and railways into a synergic ecosystem sharing digital infrastructures, safety and certification processes to lower energy consumption and pollution. HELMET capability to operate UAVs increases the safety by introducing new means for integrated car and train automation. The high integrity and high accuracy platform relies on the Consortium’s know how of SBAS-EGNOS technology to stepping into the multi-constellation multi frequency and multi sensor domain to fight back against common hazards characterizing land mobile scenarios. HELMET will develop innovative algorithms with multi-sensors and a representative proof of concept to be tested in Italy, on the l’Aquila town test bed of EMERGE, the Italian project based on Galileo and 5G for the connected car coordinated by Radiolabs. Collaborative effort is foreseen with rail, road stake-holders and with the RTCM Committee on GNSS-based High Accuracy Applications already involved on train and car applications. The outcomes of HELMET are along the way to set up and operate such services that are crucial to enable cost-competitive vehicle’s positioning beyond the state of the art. HELMET consortium is composed by Radiolabs, DLR, Sogei, University of Pardubice, Stanford GNSS team, already partners in RHINOS project and  two SMEs: RoboAuto for the driverless car and Kentro Kainotomon Tecnologion for GNSS technology. HELMET will seek to