RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Numerical Characterization and Modelling of Syngas Combustion' (SYNGAS) targeting Seventh Framework.

assistant: **Abstract**

In order to meet the EU targets on renewable energy and greenhouse gas emissions, there is an urgent need to increase the use of renewable fuels such as syngas and biogas. In the mean time, the low efficiency and emission problems associated with non-premixed combustion systems are also driving the move away from such systems towards lean premixed conditions where fuel is mixed with excess air prior to combustion. Despite substantial progress achieved in turbulent combustion, there still lacks the understanding of the following four phenomena in the context of premixed mode: (i) development of flames (ii) influence of high-pressure on turbulent burning velocities, (iii) preferential diffusion effects which are most pronounced in mixtures that contain free hydrogen, and (iv) flame quenching by very intense turbulence is still poor.The project is aimed at numerically characterizing the burning behaviour of premixed syngas and biogas combustion and developing large eddy simulation (LES) techniques to facilitate the study and design of practical combustion systems for such sustainable fuels. The main objectives are:•To carry out numerical investigations of the aforementioned three important phenomena, i.e. (1) development of syngas premixed flames; (2) influence of high-pressure on turbulent burning velocities; and (3) preferential diffusion effects.•To develop a turbulent reacting flow model that captures the underlying physical and chemical processes in flame development, the pressure and Lewis number effect; and to•To validate the numerical model with published experimental data.The project will result in a validated LES based predictive tool within the frame of open source CFD code OpenFOAM for multidimensional numerical simulations of syngas/biogas premixed flames unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular tools for monitoring emergence and spreading of drug resistance among natural populations of leishmania' (LEISHNATDRUG-R) targeting Fifth Framework.

assistant: **Abstract**

Leishmaniasis is a severe health problem in DCs and Europe. Pentavalent antimonials (SbV)will remain the first line drug for the forthcoming years. Control is being challenged by increased SbV resistance. Our aim is to design molecular tools for detecting emergence and spreading of drug resistance in visceral and mucocutaneous leishmaniases. To achieve this, we will obtain samples from SbV susceptible and refractory patients (Nepal, Bolivia, Peru ), identify molecular modifications associated with SbV resistance in FIELD isolates, transfer this Knowledge into molecular tools for drug resistance diagnosis, and define the population structure of sensitive and resistant isolates for understanding the epidemiological dynamics of drug resistance. Outputs: collection of naturally resistant parasites, knowledge on natural mechanisms generating SbV resistance and its transmission, PCR tools for preventing therapeutic failure and guidelines for their use in epidemiological surveillance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Estimation and control under limited information with application to biomedical systems' (Cont4Med) under Horizon 2020.

assistant: **Objectives**

The goal of this project is to develop estimation and control strategies for systems where only a (very) limited amount of information (measurements and models) is available. The main motivation to consider these problems are biomedical applications, where such a small amount of available information is often inherent. Examples include hormone concentration measurements when considering thyroidal diseases (which are typically only taken every few days or even weeks) or monitoring the size of a tumor. Estimating the current state of the system and devising appropriate control actions is very challenging in such applications. This is not covered by existing approaches in the literature, necessitating the development of novel methods and tools. Within this project, I will in particular focus on the following aspects. First, observability of nonlinear systems subject to few (sampled) measurements will be studied and sampling strategies together with suitable nonlinear state estimators will be derived. Second, state estimation and control strategies will be developed for situations with only partial or no model knowledge. Again, this is of intrinsic importance in biomedical applications where often the underlying physical principles are only partially understood or too complex. This necessitates the design of data- and learning-based methods, for which desired guarantees can be given, even in case of few measurements. Third, the developed tools will be extended to large-scale systems, where estimation and control has to be achieved in a distributed fashion. The successful achievement of the project goals will (i) enable estimation and control in systems with very few, sampled measurements, (ii) constitute a big step towards a holistic data-based systems and control theory, (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Biomimetic MAGnetic nanoparticles with homotypic targeting for combinatorial theraNOSTICS of triple-negative breast cancers'.

assistant: **Concept**

Cancer is a leading cause of death and is a major impediment to increasing life expectancy around the globe. Amongst all breast cancers (BC), triple-negative breast cancers (TNBCs), are of much concern, as chemotherapy is the only option. However, it is associated with chemoresistance owing to drug efflux. Moreover, since TNBCs are negative for estrogen (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER 2), treatment strategies targeting these receptors do not work. Combined strategies for TNBCs have strong potential in treating TNBCs, as compared to singular approaches. Thus, MAGNOSTICS aims to develop biomimetic cancer cell membrane (CCM) coated magnetic nanoparticles for chemotherapy, gene targeting, and magnetic hyperthermia as a triple strategy for TNBC therapy. In addition, MAGNOSTICS proposes multimodal theranostics incorporating MRI enabled by MNPs. To promote cellular uptake and immune escape, MNPs will be loaded with CDDP and siRNA and camouflaged with CCM derived from TNBC cells. CCM coating will utilize the homotypic targeting strategy for self-recognition and uptake of NPs. Thus, the objectives are; i) to synthesize and characterize CCM coated MNPs conjugated with CDDP and siABCB1, ii) to study the biocompatibility/uptake and single therapeutic strategies as proof-of-concept in 2D cell cultures, iii) To develop 3D multicellular tumor spheroids and demonstrate the effectiveness of camouflaged NPs as combined theranostic platform; iv) to ensure further professional development of the ER through training, dissemination and public engagement. MAGNOSTICS thus aims to improve TNBC treatment and impact society with the right term and place.


**Keywords:** Triple negative breast cancer, Drug delivery, Gene silencing, Hyperthermia, Magnetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strategies towards the sustainable household' (1994-1998).

assistant: **Concept**

SUMMARY This research project is concerned with the evaluation and development of strategies for transitions towards sustainable households. It will apply and futher develop the Dutch 'sustainable washing' methodology to three household functions in five countries. The main Results will be:  - case examples of imaginative scenarios, endorsed by a range of social partners, for the fulfilment of functions of the sustainable household; these scenarios will be subject to environmental assessment, economic analysis and consumer acceptance analysis. - comparison of cultural and structural aspects of the scenarios and assessments across the European countries taking part in the study. - a tested methodology which enables companies, governmental policy organizations and ngo's to carry out their own analyses of sustainable functions; the methodology will include scenario-building, the use of industry-consumer-government focus groups and methods of assessment of sustainable futures. The study will have clear policy relevance for local, national and European-level governments in devising regulatory, support and other schemes to encourage greater sustainability. The work proposed here would cover several tasks of theme 4 of the Environment and Climate workprogramme: Human dimensions of environmental change" namely: - area 4.1, especially 4.1 3 - area 4 2, especially 4.2.1, dot 4, and 4.2,2 From the Updated Workprogramme (July 1996) the section "Socio-economic development and environmental sustainability: im roving the links" should be mentioned."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Management, Exchange and Representation of Component Information'.

assistant: **Concept**

The flow of component information from component manufacturers to users is important for the cost effectiveness of product development. MERCI will build a commercial service agency to support this information flow. The service agency will use standards (P-Lib, IEC61360, PCIS) and make them interoperable. It will support the transformation from data sheets and legacy data into the standard formats and from standard formats into libraries of CAD systems. Beside other services, it will also allow electronic commerce of components.In parallel activities,(1) the software infrastructure will be developed based on standard software and software of partners,(2) the service agency will be installed and maintained, and(3) services will be validated in pilot applications.MERCI will organise an Industrial Interest Group with early access to the services. Its feedback and requirements will influence the final set up of the service agency.Objectives:The flow of component information from component manufacturers to users is important for the cost effectiveness of product development. MERCI will build a commercial service agency and the required underlying software infrastructure to facilitate this information flow. The service agency will use standards (P-Lib, IEC61360, PCIS) and make them interoperable. It will support the transformation from data sheets and legacy data into the standard formats and from standard formats into libraries of CAD systems. By mechanisms for the exchange of change information and the electronic commerce of components, it will strengthen the supplier-customer relationships. Particularly SMEs will get more independent of big component manufacturers by the neutral service agency. MERCI will continue the strong European role in the area of component informatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Stability, identification and control in nonlinear structural dynamics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The research on non-linear structural dynamics has experienced breakthrough developments in the last decades, both in the theoretical and applied fields. This is the result of extraordinary efforts undertaken by several leading international research groups, ranging from applied mathematics to physics and engineering. The impact on the technological applications has been growing concurrently with the fundamental research, and the industry has started to drive serious attention towards these new and emerging design paradigms. In numerous cases, the generated refined knowledge of the non-linear phenomena has enhanced the design and the production leading to sustainable engineering products and processes. Nevertheless, differently from the established academic trends in the USA, in Europe less attention is being placed towards coordinated teaching programs addressing non-linear dynamics disciplines.However, several leading European research groups, in some cases strongly interacting, are currently undertaking successful and internationally recognized efforts tailored to fundamental and applied findings in non-linear dynamics. This has determined a unique opportunity for transferring the most advanced knowledge achieved by the senior researchers to young fellows in the early stages of their career.The present proposal is structured in a series of training courses and international conferences. In particular, the topics addressed are:(i) stability and bifurcations of non-linear dynamical systems;(ii) advanced non-linear dynamics and chaotic dynamical systems;(iii) vibration testing, identification of linear and non-linear systems;(iv) non-linear dynamics and control of structural and mechanical systems;(v) model identification and damage detection.The courses and conferences
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards successful dengue control' to be submitted under Sixth Framework.

assistant: **Abstract**

Dengue, the most rapidly expanding viral disease in S-East Asia and Latin America, is a major neglected and uncontrolled disease. This project will provide new knowledge, tools and strategies in 3 key areas: 1. Improved knowledge of the immunopathology of severe dengue contributing to the development of a safe and efficacious vaccine and eventually to improved treatment 2. Improved case-management through a modified dengue case definition and treatment guidelines and eventually the identification of early w arning signs for severe disease 3. Improved protection from disease transmission by means of novel vector control tools which are applied through a new cost-effective strategy The specific objectives of the project are: 1.To create new knowledge about viru s genetic factors of virulence, immune response and pathophysiological mechanisms across regions (SE Asia and LA) relevant to clinical management of severe disease and vaccine development 2a) To obtain a clear distinction between dengue and severe dengue b y developing an evidence-based case classification procedure 2b) To develop case management guidelines that will use the revised case classification and subsequently reduce morbidity and mortality 3.To test novel vector control tools (long-lasting insectic ide treated curtains and/or water container overs and/or slow-release insect growth regulators) which reduce vector densities below epidemic threshold levels 4.To assess key strategies which deliver new vector control tools regarding their cost-effectivene ss,acceptability and sustainability in contrasting environments 5.To demonstrate and document the timely translation of research findings into policy and practice (clinical as well as control) The 5 work packages related to these objectives are designed by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '2.3.3/10 detailed service analysis (Galileo). subtask 2: user tools' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Galileo will constitute a common tool for all European citizens in the near future. Therefore, users must have an understanding of the system and provide requirements to the system design. Currently, there is no link between the GNSS user and application needs and the Galileo system design.The objective of this proposal is to provide a SW tool which will provide the link between Galileo System design and users. This SW tool will be called Polaris. Polaris will contribute significantly to the development of Galileo by providing a link between users and Galileo developers. Polaris will help identify new GNSS services, optimise the Galileo system from a user point of view, and optimise the Galileo Service Definition. This optimisation will result in multiple social benefits, in addition to the direct commercial benefits of Galileo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Advanced Radio Interface Technologies for 4G Systems'.

assistant: **Innovation**

The first 3GPP Long Term Evolution standard version is complete and ready to be deployed. Although it increases peak data rate and spectral efficiency compared to legacy techniques, cell-edge and average user throughputs are still significantly lower than the peak rates. In the LTE-Advanced Study Item, ways to extend LTE are being explored. However, some of the considered techniques are complex and significant research efforts are needed to bring these techniques to reality.<br/>The main ARTIST4G project objective is to improve the ubiquitous user experience of cellular mobile radio communications systems by satisfying the following requirements:¿\tHigh spectral efficiency and user data rate across the whole coverage area¿\tFairness between users¿\tLow cost per information bit¿\tLow latency<br/>This objective will be achieved by developing innovative concepts out of promising ideas from the research ecosystem, and benchmarking them with the state-of-the-art. The technologies identified to fulfil the above requirements are:¿\tInterference avoidance¿\tInterference exploitation¿\tAdvanced relay techniques<br/>ARTIST4G will build upon projects such as EASY-C, where first steps towards integration of these technologies in cellular systems have been made, but also address new aspects like:¿\tAdvanced multi-cell scheduling for adaptive and efficient usage of interference management and relaying techniques in appropriate scenarios¿\tImpact of the innovative concepts on the network architecture<br/>ARTIST4G will not only use theoretical analysis and simulations to develop and validate innovative concepts based on these technologies, but also enable proof-of-concept via hardware prototypes and field trials in a representative testbed.<br/>It is expected that ARTIST4G will create
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Membrane-cytoskeleton interactions and tumour suppression.'.

assistant: **Concept**

Tumour suppressor genes act as recessive determinants of cancer. It is recently known that various actin-associated cytoskeletal proteins and structural components of intercellular junctions are encoded by, or are related to products of tumour suppressor genes. Very little is known of how tumour suppressor molecules associate with or function at the cortical membrane skeleton and/or specialised junction domains. To understand the molecular events governing tumour suppressor activity, extensive molecular cell biology studies have to be implemented. This is the major objective of our proposal.As a choice of tumour suppressor, we will study schwannomin. Schwannomin is the product of the NF2 gene which, when mutated at the germline level, causes neurofibromatosis type 2, a tumour susceptibility disease predisposing mainly to meningiomas and schwannomas. Schwannomin, together with ezrin, radixin, and moesin, comprise the ERM family of membrane cytoskeletal linker proteins. To define the specific activity of schwannomin requires an understanding of the role of each member of the ERM family. Moreover, since ERM proteins are involved in adhesion events that are essential for the control of epithelial cell differentiation and growth, we will also investigate how the assembly of junctional membrane domains, such as tight and adherents junctions, is regulated. To understand how these various sub-membranous protein complexes function will require us to analyse the multiple interactions that occur between the numerous components involved. Especially, we will investigate how changes in interactions can mediate tumourogenic potential since activation of membrane receptors (notably HGF/SF receptor, the product of the c-met proto-oncogene) can initiate signal transaction via ERM and jun