RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CARbon nanoTube phOtONic devices on silicon' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Primary goal of the proposed research action is the development of a novel strategy for hybridizing silicon based photonic devices, exploiting semiconducting carbon nanotubes (CNT) as integrated light source, modulator and detector. Photonics in Information and Communication Technologies is more and more investigated for a broad application domain. These applications require efficient optoelectronic devices to emit, modulate and detect light. To facilitate photonic and electronic convergence, the envisioned approach is based on the silicon platform. However, the definition of optoelectronic devices requires several kinds of materials (Si, Ge and III-V) as silicon is an indirect-gap material with poor electro-optic properties. This project aims at investigating a new and innovative field through the use of CNT in the near infrared wavelength range. The main breakthrough will come from the development of CNT-based optoelectronic components directly co-integrated within a silicon platform to address the major challenges of photonics. Such integration has never been investigated so far and thanks to a joint experimental and theoretical investigation our major goal is to establish the potential of CNT technology for nanophotonics applications. The project reposes on three major cornerstones: (i) A waveguide detector in the 1.3-1.6µm wavelength range, (ii) integrated optical modulators using Kerr (electro-refraction) and Stark (electro-absorption) effects and (iii) An integrated electrically pumped optical nanosource. Each of these cornerstones will be a world's premiere and will constitute a breakthrough. Inherently, this makes it a high risk/high gain yet achievable proposal with a foundational impact both in knowledge and technology for nanophotonics. In a long term vision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Key aerodynamic technologies for aircraft performance improvement' to be submitted under Fifth Framework.

assistant: **Abstract**

The goal is to provide a communication platform for all aircraft disciplines concerned directly or indirectly with aerodynamic performance improvement including design and system integration, structures, materials, manufacturing, operational and maintenance aspects. KATnet intends to bring together engineers, designer and scientists from all Concerned disciplines in order - to enhance the information/data exchange between industry and research community - to identify future RTD priorities meeting the long-term needs - to accelerate the interdisciplinary design process - to improve the flight performance of future transport aircraft.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GoldenWorkers' to be submitted under Seventh Framework.

assistant: **Abstract**

Longer life expectancies and low birth rates together impacts on the demographics of the workforce. The proportion of 50- to 64-year-olds in the workforce will be double in size compared to workers younger than 25 years (35 versus 17%) in the EU15 (the first 15 European countries to join the union) by the year 2025. Several EU15 countries will face this challenge by 2010 and the situation is expected to last for decades. The new member states of the EU do not ease the greying picture, rather the opposite and immigration will only be a minor solution to the problem.A marked paradox exists between a longer life and a shorter working life. More healthy years will be spent in retirement than in work. So, the problem is not higher life expectancies but earlier retirement.<br/>Improved health and technological advances make it possible to extend work life beyond age 65 extending independence, productivity and quality of life.Ageing–related technological innovations can help ageing to stay at work and they fall into four technological categories:\tenabling technologies (which assist people to age in place")\toperational technologies (which assist aging people to function in society)\tconnective technologies (which assist aging people to communicate with caregivers, families and medical resources and vice versa)\ttelemedicine (which allows a medical source or caregiver to monitor, diagnose and/or treat patients from a distance).According the above concepts GOLDENWORKERS's main objectives are:\tDevelop an RTD roadmap for active aging at work\tCreate a set of realistic scenarios, based on the socioeconomic conditions that are present in the different regions of EU27\tValidate scenarios and existing gaps with stakeholders\tIdentify shared RTD roadmap (among Industry, SMEs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Retinal mechanisms of circadian photoreception', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The post-doctoral research proposal aims lo determine the functional organisation of the sensory photic pathway involved in mediating circadian entrainment in mammals. The ralionale for this study is based upon I) accumulating evidence that the neural substrate controlling photic circadian responses is distinct from the visual channels subserving image formation and visual perception. and 2) the lack of knowledge concerning the specific opsins and associated neuronal chain (photoreceptors. intraretinal neurons ganglion cells) providing photic information to central circadian pacemakers The concept of an independent pathway devoted to photic regulation is of fundamental and clinical interest and is relevant to health related issues of chronobiological disorders and temporal pharmaceutical treatments in humans. The specific objectives of the study will focus on defining the neuroanatomical components of entrainment pathway and an analysis of the spatial and spectral response properties. The research strategy will rely on the use of animals with selective genetic Iesions within the retina and altered photoreceptor populations. These include mice with hereditary retinal disorders in which the retinal photoreceptors have either partially of fully degenerated. This photoreceptor degeneration Ieads to the loss of visual function although circadian responses to light remain unattenuated. A second model includes transgenic mice in which rod and/or cone photoreceptors have been eliminated by attaching the attenuated diptheria toxin gene (DTA) to the human rhodopsin promoter (or to cis elements for cone expression). These models will be particularly helpful for isolating those components of the retina required for circadian responses to light. In ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of protein-tyrosine phosphatases in angiogenesis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Angiogenesis is the formation of new blood vessels from pre-existing ones and is involved in different physiological and pathological processes such as cancer and ischemia. Tyrosine phosphorylation is a reversible process, mediated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). Although the role of PTKs in angiogenesis is well established, little is known about the function of specific PTPs in this process. In collaboration with Dr. H. Augustin, (Heidelberg, Germany) we found that the expression of several PTPs changes when spheroids of endothelial cells embedded in 3D matrices are exposed to angiogenic stimuli. To investigate the role of PTPs in angiogenesis, we generated a tetracycline-inducible shRNA library for targeting PTPs. We are also generating lentiviral vectors expressing inducible cDNAs of all the human PTPs. I propose to investigate the biological role of PTPs in angiogenesis by loss- and gain of function experiments in endothelial cells, using different in vitro and in vivo angiogenesis assays. My studies will determine the role of PTPs in developmental and pathological angiogenesis and test their merits as targets of angiogenic therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Large scale perturbations of the gene regulatory networks of E. coli' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Although genome sequencing is well advanced, our understanding of the genome to phenotype to fitness relationship remains very poor. It is becoming very evident that the information stored in genes is not enough to understand their impact without knowing the phenotypic and environmental context. The fact that a gene is present in a genome tells very little about when it is expressed and its relationship to other genes and mutual effects on gene expression pattern. To understand how phenotypes emerge from a specific genotype, we need to understand gene regulatory networks and their mechanisms of regulation. In this project, I propose to study the relationships between genotype, phenotype, fitness, and environment using a microfluidic device coupled with transcriptomics with the goal of collecting high dimension high quality data for unprecedented level of understanding and predicting regulatory networks, evolution, and evolutionary constraints in the form of epistasis and pleiotropy. I will use programmable DNA binding protein called CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) to perturb gene expression of (1) combinatorial global regulators within the transcriptional regulatory network, (2) cascades of genes that form gene network hierarchy, and (3) single global regulators with low level mutations at many positions in their genetic code. I will then quantify the expression pattern of the transcriptome using RNA sequencing and the growth fitness of each strain. The environment will be highly controllable as we will create a cutting-edge microfluidic system to study many strains of bacteria in a high-throughput manner. Successful implementation of the strategies explored in this project will open the doors to plenty of other avenues to explore with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Controlled Singlet Oxygen Release Photosensitizers in Photodynamic Therapy' (CONSORT), addressing dissemination and exploitation.

assistant: **Impact**

Photodynamic therapy is a form of phototherapy which uses light-sensitive compounds (photosensitizers) that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells. The photosensitizer creates a highly reactive singlet oxygen species which rapidly reacts with any nearby biomolecules leading to destructive reactions resulting in cell death through apoptosis or necrosis. However, prolonged exposure of tissue to light irradiation causes photosensitivity in patients’ skin. Side effects may include, pain, burning/stinging sensation, itchiness. This proposal aims to develop a conceptually new approach towards photodynamic therapy through an introduction of new type of photosensitizers and corresponding nanomaterials which are capable to generate singlet oxygen upon irradiation, store it by means of binding to special molecular subunits and slowly release singlet oxygen within tissue on a timescale from several hours to several days after light irradiation treatment. The application of such novel material will allow for increasing therapeutic effect and reduced side-effects with respect to conventional PDT due to shorter light treatment duration. Proof of concept will be attained by demonstration of delayed singlet oxygen formation in cancer cells after the light treatment using in vitro models. The project builds on the strengths of the applicant in organic chemistry, photophysics and material science and combines these with new training in biomedicine and drug development to open a new research direction and to enhance cross-European collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reproductive behaviour and sexual selection in a sex-role reversed blenniid fish, salario pavo' to be submitted under Fourth Framework.

assistant: **Abstract**

The aim of this study is to investigate central questions in sexual selection; Why do mating preferences and sexual ornaments evolve? Why are males usually active in courtship and compete for mates, while females are choosy? Several factors have been suggested to explain sex-roles. Most studies have focused on competition for mates, and only a few studies have attempted to explain sex differences in choosiness; but the operational sex ratio (OSR) and variation in mate quality seem important. This study would be among the first to adress these questions empirically.  Salaria pavo (Pisces: Blenniidae) exhibit paternal care and males devel sexual ornaments. In the study population, the OSR is female-biased and females court and compete for access to males, thus sex-roles are reversed. I will investigate mate choice of both sexes, potential benefits of carrying out mate choice, and the function of the male sexual ornaments. This unique system provides excellent opportunities for testing important sexual selection theory and obtain novel results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Construction of new G2 manifolds using Calabi-Yau 3-folds' (2002-2006) under Sixth Framework.

assistant: **Objectives**

We intend to study G2 manifolds and their relations with Calabi-Yau 3-folds. These are geometric objects in 6 and 7 dimensions that have been attracting much attention recently from both mathematicians working in differential geometry and from theoretical physicists studying super-string theory, super-gravity, and M-theory. We have a very clear objective in mind, to construct many new explicit examples of compact G2 manifolds starting from a Calabi-Yau 3-fold N possessing an anti-holomorphic involution. Such a structure determines a special Lagrangian submanifold L of N. There is then a canonical way to construct a 7-dimensional orbifold M by taking a quotient of N x S1 by an action defined from the given involution and a natural involution on the S1 circle factor. The singular set of this orbifold is the union of two copies of the special Lagrangian submanifold L. We plan to resolve these singularities and obtain smooth, compact 7-manifolds with holonomy G2.The proof of the existence of a parallel G2-structure on the resulting smooth 7-manifold will involve techniques of non-linear analysis similar to those developed by the proposed scientist in charge, Professor Dominic Joyce when he constructed the first examples of smooth compact G2 manifolds in 1993-4. Such constructions are important both for differential geometry and for super-string and super-gravity theories. The achievement of this goal would be an important step in the evolution of our understanding of these physical theories, and their close relations to differential geometry. Much of the recent spectacular progress in research in differential geometry has been inspired by similar questions arising from theoretical physics, and the cross-disciplinary benefits to both sides have been unquestionably significan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Time-determined ontology based information system for real time stock' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of the project is to expand the current state of the art ontology languages (OWL, RDF-S, RDF) and their support for automated reasoning by adding the time dimension to enable real time context aware information analysis. This technology will provide ontology based (semantic) information systems to venture beyond a static world and add the concepts of time and change.To demonstrate and objectively assess the quality of the project result a semantic stock broker system will be developed based on a time determined ontology (TDO) of which the actual state depends on Reuters textual news messages and numerical market information. The system interprets these messages and adapts its dynamic ontology to better match the real world as described in the news. The potential general impact of a effective time determined ontology language and reasoner technology is fundamental for all aspects of the IST objectives. It will affect knowledge acquisition, organisation, personalisation, share and use of all types of ontology based knowledge. Implementation of the time dimension in formal knowledge representation is a prerequisite for effective semantic interoperability between information sources of any nature, content type or language. And additionally, combined with time aware reasoners and feature extraction tools, this will promote self describing content and responsive behaviour to user needs.The potential strategic impact of the demonstration application in the stock exchange domain results from an improved return of investment by using an effective knowledge system support. By adopting the project results in the financial markets, this may add to the resolution of the low liquidity status of institutional investment institutes. This has a impact for millions of Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Saving millions of lives by enabling an effective treatment for Heart Failure patients; V-LAP, a revolutionary, miniaturized implant and its dedicated wearable device.' (V-LAP) under Horizon 2020.

assistant: **Objectives**

Heart failure (HF) is a chronic condition affecting 1 in 5 people aged over 65 worldwide: heart is unable to pump enough blood flow to meet the body needs. The resulting excess of fluids in body and organs causes dyspnea, edema, leg swelling and tiredness, decreasing patients’ life quality. The sudden worsening of symptoms is called Acute Decompensate Heart Failure: a life-threatening condition with 30% mortality within 12 weeks. HF costs are high: 28 B€/year to EU NHS, 2% of total healthcare expenditure, the major part due to hospitalization. There is today a global call to increase awareness in HF, whose management is still highly ineffective. The transition from HF to the acute condition takes weeks but its earliest indicator, an increase in left ventricular filling pressure (LV), can only be measured invasively, in a hospital.   Vectorious’ disruptive device is a miniaturized, battery-free, implantable hemodynamic monitor capable of detecting the rise in LV during patient’s daily life. The implantable, completely covered by Vectorious’ patents portfolio, is deployed trough a minimally invasive, catheter-based procedure. A belt-like external device is worn by the patient over the clothes 3 min/day: via inductive AC coupling, the implantable is powered so pressure data can be collected and sent back to the external unit which synchronize with the patient’s mobile device and with a dedicated website for the healthcare provider. A green/yellow/ red color code widely known among HF patients allows them to promptly adjust their  medications, according with their clinicians’ prescription. V-LAP will be able to predict at least 98% ADHF events, HF management will become as simple as manage glucose levels in diabetes.   During Phase 1 project the Company will assess scale-up