RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Preclinical study of Recombinant human Anti-C5 for the Treatment of atypical HUS' (PRATH) targeting Seventh Framework.

assistant: **Abstract**

The Complement System is implicated in the onset, maintenance and amplification of tissue damage in several inflammatory clinical conditions. Haemolytic uraemic syndrome (HUS) is a systemic disease characterized by damage to endothelial cells and erythrocytes, thrombocytopenia, micro thrombosis and kidney failure. During the last few years it has become evident that familial atypical HUS is strongly associated with mutations in proteins needed either for activation or regulation of the alternative pathway of Complement. For this reason, ADIENNE S.r.l. (Italy) has obtained orphan designation EU/3/08/571 for its Recombinant human minibody against Complement component C5 for the treatment of atypical Haemolytic Uraemic Syndrome (aHUS) associated with an inherited abnormality of the Complement system in September 2008. This molecule has been already characterized by in vitro and in vivo experiments and a complete preclinical study is the next step for the development of this potential orphan drug useful for the treatment of aHUS. Preclinical studies of this EU designated orphan medicinal product has been design by ADIENNE S.r.l. and will be perform in collaboration with the University of Trieste (which has isolated and characterized the recombinant human antibody against C5), the Imperial Collage of London, ADIENNE Spain SL and CIT-Safety and Health Research Laboratories. In this two years project we plan to perform pharmacological, pharmacokinetic and toxicological studies, a pre-clinical evaluation of the therapeutic efficacy of the anti-C5 antibody in mouse models of aHUS and characterization of GMP-grade anti-C5 antibody production. Data collected in this project will be sufficient for a complete “Preclinical development of substances with a clear potential as orphan dr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gate2Brain. Medicines beyond barriers.' (Gate2Brain).

assistant: **Innovation**

In 2019, 30 million people worldwide were diagnosed with some form of CNS disorder and most of them lack effective treatment. This is largely explained by the fact that most of developed therapeutic molecules do not contain the appropriate properties to cross the BBB. Consequently, CNS disorders are the first cause of disability, and the second of mortality worldwide. Gate2Brain is a technologic platform based on a set of small peptide-shuttles that have the capacity to cross the BBB and carry to the CNS therapeutic cargoes that cannot reach the brain unaided. G2B-002, our flagship product, is a new therapeutic approach to fight against untreatable pediatric brain tumors with intact BBB. G2B novel delivery technology provides a non-invasive, non-antigenic, stable, soluble, and receptor-specific way to transport drugs across the BBB to reach the CNS. Our technology has the potential to be applied in a wide number of therapeutic areas and in transport through various biological barriers.


**Keywords:** Immunotoxicity,peptide synthesis,drug-shuttles,blood-brain barrier,therapeutic molecules,paediatric oncology,peptide-shuttles,Brain Drug Delivery Systems,Drug delivery,Central Nervous System,Glioblastoma,Drug development,Pharmaceutical industry,Brain delivery,Solubility,peptides,peptide chemistry,peptide drug conjugates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the role of heterochromatin regulation in spermatogenesis through a Sex Ratio meiotic drive system in Drosophila' under Horizon Europe.

assistant: **Concept**

Spermatogenesis is a crucial and intricate biological process for species continuity. The sex ratio (SR) meiotic drive system, prevalent in many organisms, skews offspring sex ratios by manipulating sex chromosome inheritance during meiosis. While the underlying molecular mechanisms remain elusive, recent studies suggest that heterochromatin regulation may hold a central role in most SR systems. The HetY project aims to uncover the role of heterochromatin regulation in spermatogenesis by exploiting a natural meiotic perturbation : the Paris SR system in Drosophila simulans. This system is characterized by sister chromatid nondisjunction of Y chromosomes during meiosis II, induced by two X-linked drivers, including a malfunctioning Y-linked heterochromatin protein. We hypothesize that misregulation of Y heterochromatin is responsible for this nondisjunction. Our first objective is to identify the target(s) of the X-linked driver, using advanced CUT&Tag techniques. Some Y chromosomes resist to drive, potentially due to their intrinsic ability to evade perturbations of their heterochromatin landscape. Our second objective is to characterize those perturbations, through a comprehensive transcriptomic analysis to pinpoint extensive changes in heterochromatin landscapes. Recent findings indicate that the resistant ability of Y chromosomes correlates with their simple satellite repeat composition, and studies suggest that simple satellite expression is essential for male fertility. Our third objective is to probe the role of simple satellite RNA in chromatin organization and spermatogenesis. To this end, we will design shRNA against simple satellites identified in our previous study, assessing their influence on the sex ratio phenotype and potential induction of morphological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Food Safety and Hygiene Networking within New EU Countries and Associated Candidate Countries' (SAFOODNET).

assistant: **Concept**

This SSA will build-up a sustainable network in food safety. It aims at knowledge sharing to prevent risks related to microbial hazards, to find future RTD needs and apply for RTD funding in food processing and packaging safety. The action will focus towards Czech Republic, Denmark, Estonia, Finland, Hungary, Latvia, Slovenia and Turkey in the pilot actions, seminars, and workshops on process hygiene and end product safety. Interested researchers and SME representatives from other new EU countries and ACCs will be encouraged to participate in the activities.The objectives of SAFOODNET are to:1) disseminate knowledge from national and international food safety projects in open seminars, workshops, practical exercises, RTD activities and pilot actions resulting in new research projects for food industry especially SMEs;2)establish an expert group (EG)in which authorities, scientists, industrial representatives build-up or strengthen existing networks and identify specific needs for future RTD activities in food safety and3) bridge networks within the new EU, fostering scientific co-operation and knowledge transfer in food safety.The expected achievements of SAFOODNET are: 3 open seminars in microbial contamination routes, risk assessment and management to disseminate safety issues to a targeted audience of industrial, research and authority people; 2 workshops incl. practical exercises in microbial risk assessment and management to disseminate methodologies and methods; establishment and maintenance of the project network using a project web-site, which partly is public; establishment of an EG to suggest and evaluate pilot actions for future needs in RTD activities; performance of pilot actions in food safety suggested by the EG in food industry especially in SMEs as a ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Militant Science. European Physicists and the Emergence of Transnational Radical Science Movements' (MISHA) under Horizon 2020.

assistant: **Objectives**

MISHA’s research objective is to understand the transnational emergence and flourishing of radical science movements with a particular focus on the physics communities in Italy, France, United Kingdom, and the United States. I aim at elucidating the dynamic of the two-way transfer of knowledge and people between the US and Europe. The project consists of the following research actions: archival research (e.g., Niels Bohr Library & Archives, American Institute of Physics, Cambridge University Library, Wellcome Library, Archives de Jussieu, Sorbonne, Fondazione Lelio e Lisli Basso, University of Rome La Sapienza, Archivio della Società Italiana di Fisica); systematic analysis of written sources, (European and American journals, monographs, and translations of essays and articles); reconstruction of scientific networks from the examination of conferences proceedings, summer schools programs and lectures, and seminars, as well as programmatic documents; reconstruction of institutional and informal networks (political militancy, correspondences, internal reports); definition of the epistemological and political features of the debate on non-neutrality in science at transnational European level. On the methodological side, I will employ the most advanced conceptual tools of transnational history and political epistemology to provide an integrated narrative able to combine political, philosophical, and historical analysis.


**Keywords:** history of physics ,  radical science movements ,  history of science during the cold war ,  political, epistemology,  scientific networks ,  philosophy of science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Individual Differences in the Biological Embedding of Developmental Origins of Health and Illness in Syrian Refugee Children' (RefugeeBioEmbed).

assistant: **Innovation**

The Syrian Civil War led to the displacement of more than 5.6 million Syrians in surrounding nations, millions of whom are children. Nations around the world are striving to resolve the economic, cultural, and societal strains of accommodating an unprecedented number of refugees. The proposed project aims to begin tackling this problem by investigating experiences of Syrian refugee children to determine whether individual characteristics influence their psychological and behavioral responses to the Syrian Civil War and subsequent circumstances. The research objectives entail applying innovative, evolutionary-developmental models to explore individual differences in the ways early childhood adversity is biologically embedded and reflected in developmental milestones and mental health. The project applies strong interdisciplinary methods to the analysis of existing, high-quality data to understand the intersections of genetics, endocrinology, psychology, and behavior. The overarching goals of the project are to 1) understand individual differences in the developmental origins of health and illness, 2) identify modifiable risk and protective factors that suppress or enhance refugee mental health, and 3) inform individualized interventions to prevent and treat mental illness among Syrian—and other—displaced populations. Bringing to bear leading experts in neuroendocrinology, genetics, psychiatry, and resilience; high-quality, longitudinal data; and state-of-the-art training in genetic and hormonal data analyses, this project will showcase European excellence in innovative, interdisciplinary, and intersectoral research in child development and public health and policy.


**Keywords:** Life history theory, differential susceptibility, developmental timing, pubertal timing, me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Grounding through the lens of backchannels in signed conversation: Cross-linguistic insights', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

1 in 1000 deaf or hard-of-hearing individuals in the EU communicates in one of 31 national or regional signed languages (SLs) as their first language. Understanding how deaf signers of different SLs coordinate their interaction to build and maintain mutual understanding, known as grounding, is thus a key issue in unveiling the highly cooperative nature of human communication. However, research on the interactional infrastructure of SLs is still understudied. Combining insights from comparative linguistics, computational and conversational analysis, SignBack describes how deaf signers from two unrelated SLs, namely, Norwegian SL (NTS) and French Belgian SL (LSFB) achieve mutual understanding in conversation. To achieve this, I will analyse one core mechanism recognised for providing positive evidence of understanding in interaction, namely backchannels. This project will be the first cross-linguistic study to adopt a synchronic, corpus-based approach to SLs by combining quantitative statistical processing with a qualitative, interactional view on language to achieve a better understanding of human interaction in context. The integration of these methods across SLs will provide key insights into the interactional practices of two linguistic minorities, thereby further contributing to a more dynamic and semiotically diverse view of language. SignBack will make a major contribution to the field of (SL) linguistics by further documenting two under described SLs. It will provide vital implications to a range of domains including (i) curriculum design for SL interpreters, (ii) effective development of SL-based human-computer interaction and (iii) baselines for clinical research investigating impaired social functioning. The innovation of this project therefore lies not only in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nano-Engineered Co-Ionic Ceramic Reactors for CO2/H2O Electro-conversion to Light Olefins' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

As a major contributor to the global CO2 emissions, the commodity chemical industry should be urgently coupled with renewable electricity to become independent from fossil fuel resources. ECOLEFINS aims to establish a new, all-electric paradigm for the electro-conversion of CO2 and H2O to light olefins, the key-intermediates for polymers and other daily life chemical products. The proposed concept reverses the heavy CO2 emissions associated to the petroleum-based light olefins production to massive CO2 capture and valorisation for carbon negative ethylene, propylene and butylene. The concept introduces co-ionic ceramic membrane reactors and short-stacks/modules that merge the anodic steam electrolysis for hydrogen production with the cathodic CO2 electrolysis and hydrogenation to light olefins, over tailored and nano-engineered electrodes; aiming to develop a substantially more effective technology, for the single-step, RES-powered artificial photosynthesis of CO2 to valuable chemicals. This ambition entails a multi-disciplinary task, requiring highly tuned synergies among cutting edge research in the fields of: i) advanced materials science & engineering for co-ionic composites, perovskite ex-solutions, and organometallics, ii) electrochemistry and electrochemical process engineering, iii) catalysis science and engineering, iv) computer aided materials design and atomic scale modelling, and v) digital real-scale process modelling and economic evaluation, along with a comprehensive sustainability assessment, applied social research for impact framing, and marketization planning.


**Keywords:** H2O/CO2 Co-electrolysis, CO2 Hydrogenation, Light olefins, Chemical industry electrification, Power2X, Co-Ionic ceramics, Nano-Engineering, exsolution, MOFs, COFs, Electrochemica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multi-Access Services for telematic Management of Diabetes Mellitus', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This project intends to provide Multi-Access services to residential and mobile diabetic patients, in order to increase the quality of patient's care by improving communication between patients and caregivers. M2DM will incorporate new telemedicine tools providing 24 hours a day personal health services and new means to information access to physicians and patients, including Web-based services and Computer Telephony Interfaces. The M2DM service will be designed to go beyond the concept of telemedicine: physicians and patients will cooperate regardless of distance, in order to improve the quality of care. A crucial aspect of the M2DM system will be its capability of effectively managing the knowledge necessary for chronic patients care, through a collection of innovative methods and tools designed for this purpose. The final objective of our system will be to give the right knowledge to the right people in the right form and the right time.OBJECTIVESThis project intends to provide a sustainable service care to residential and mobile diabetic patients aiming to increase the quality of patient's care through improving communication between patients and caregivers. M2DM incorporates new telemedicine services that emphasise the provision of personal health care 24 hours a day and provides new means to information access to physicians and patients. A Multi-Access Server (MAS) is defined in the project comprising a full range of non-expensive and widely accepted information technologies offering to users a universal, easy-to-use, on-line and cost-effective access to telemedicine and information services. M2DM will provide the capability of effectively managing the knowledge necessary for the complex and distributed process of chronic disease care, providing technological inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biochemical reconstitution of DNA repair reactions on physiological chromatin substrates' in the context of a Seventh Framework call.

assistant: **Objectives**

For cells and organisms to survive and propagate, they must accurately pass on their genetic information to the next generation. Errors in this process may arise from spontaneous mistakes in normal cellular metabolism, or from exposure to external agents, such as chemical mutagens and radiation. To protect themselves from the consequences of DNA damage, cells have evolved a vast array of pathways DNA repair mechanisms, each optimised for the resolution of a particular problem. One method of DNA repair, called homologous recombination (HR), involves using intact undamaged DNA sequences as a template to repair the damaged copy. HR is used extensively in meiotic cells to repair DNA breaks that are purposely created by the cell. In this context, HR is not just a repair mechanism, but also a method to drive interaction and genetic exchange between maternally and paternally inherited chromosomes, creating haploid genomes which are chimeras of the parental genetic information. Thus, the study of DNA repair and recombination informs our understanding of mechanisms that maintain genome stability, but which also generate genetic diversity, topics that are as critical to the survival of an individual cell as they are for the evolution and survival of an entire ecosystem. In recent decades a great deal has been learned of the genetic and biochemical control of the DNA repair and recombination mechanism. In general we infer gene function from what happens (or doesn’t happen) when we mutate a pathway of interest, and use biochemistry to test function using surrogate, simplified in vitro assays. Here, to bridge the divide between these classic approaches, I propose to develop biochemical methods using intact chromatin prepared from living cells. I believe that integrating chromatin bi