RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sorption of metals by low cost natural materials' under Fourth Framework.

assistant: **Concept**

The purification of water and pollution control already constitute a prominent part of any industrial policy. Heavy metals are a priority aim in this field and have been the motive of considerable effort of R&D in recent years. Amongst the many aspects which together make up the environmental problem of these substances, there are two which are of particular significance in certain industrial sectors: The generally high costs of available purification systems (physico-chemical plants, ion exchange columns, washing in cascade, etc.) and the need to treat large volumes of effluents with contaminating elements found in low concentrations but which have a potentially accumulative or high toxicity effect. On the other hand, there is a wide range of natural minerals which are very abundant and relatively low cost, and which are well-known for their capacity to retain metallic ions through processes of sorption. Some of these minerals could furthermore increase that capacity by different methods of treatment. The objective of the proposed project is to study the potential of a number of these minerals which are available in the European Union, with a view to obtaining cheap, large capacity systems for water purification, the cleaning of soils and to obtain processes to seal off waste dumps in relation to contamination from heavy metals. The project consists of three different but interrelated parts: - exhaustive study of the sorption capacity of the easily accessible natural minerals; - development of methods and technology to improve the natural sorption capacity of the minerals by physical and chemical treatment; - development of applications to specific sectors (metal finishing and tanning), including the construction of prototypes. The range of industrial minerals to be co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Disability versus Difference over Development in the Autisms' in the context of a Horizon Europe call.

assistant: **Objectives**

Autism is an early developing condition diagnosed on the basis of difficulties in the domains of social-communication and restricted repetitive behaviors. However, the single label of autism masks a large degree of heterogeneity at multiple scales, from genome to phenome, and may not signal differential needs and services required for some types of profoundly affected individuals. In order to better understand autism and develop more impactful ways to facilitate positive outcomes at an individualized-level, we need better models that help to explain how autism may be differentiated in meaningful ways that help explain variability in developmental paths, responses to treatment, and differential underlying neurobiological mechanisms. This research program develops and tests the AUTISMS-3D model  disability versus difference over development - as a first-level major distinction for explaining heterogeneity within the autism population. AUTISMS-3D postulates that the major first-level split within the autism population is between subtypes described by profound disability versus difference in developmental outcomes. Stratification models using standardized clinical measures of intellectual functioning, language, and adaptive behavior will be used to predict disability versus difference subtypes. These stratification models are based on highly reproducible data-driven clustering analyses from very large phenotypic datasets. We will then test how the subtypes may develop differently with analyses of big clinical longitudinal datasets and also within the context of early intervention. Finally, we will test the subtypes for neurobiological differences via neuroimaging (MRI, fMRI, DTI) and electrophysiological (EEG) and gaze phenotypes (e.g., eye tracking) under static and natura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Géométrie Algébrique en Liberté 2001' (1998-2002).

assistant: **Concept**

PROPOSED EVENT: Euro Summer school Géométrie algébrique en liberté 2001 ( GAEL2001) PROPOSER, EAGER: a European Network in Algebraic Geometry, to be sponsored by the EC-program Improving Human research Potential and the Socio-Economic Knowledge base" (proposal number RTN1-1999-00202). KEYNOTE SPEAKERS (all confirmed): S.K. Donaldson, A.N. Tyurin, W.B. Oxbury PROJECT TOPIC: Algebraic geometry is a core mathematical discipline that has been intensively studied since the late 19th century. It provides a range of geometric techniques describing solutions to equations. Because most of mathematics is concerned at some level with setting up and solving equations, for example to model problems in applications, algebraic geometry plays a central role in mathematics and physics. GAEL2001 addresses particularly themes in one of the most exciting new areas in the whole of mathematics, with close connections to mathematical physics: the invited keynote speakers will present topics grouped around gauge theory and the special Lagrangian approach to string theory.PROGRAMME CONTENT: GAEL2001 brings together about 40 European PhD students and young post-docs with the three international experts invited as keynote speakers. Each keynote speaker gives a mini-series of one-hour lectures on the topics described above. Selected junior participants report in 40-minute talks on their current research projects. Each junior talk is followed by a discussion with particular emphasis on constructive comments by the keynote speakers. Typically, these discussions are the starting point of further junior-to-junior, junior-to-senior and senior-to-senior discussions during the lunch breaks or in the evenings. The ideal closed environment of the CIRM, Luminy (FR), provides ample space for these discussion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Textile Terminology of Hittite Anatolia' (TEXTHA).

assistant: **Innovation**

This research project will provide an accurate and updated analysis of the Hittite textile terminology. This will be achieved through a precise examination of the preserved epigraphic sources.In order to pursue this analysis, the research project needs as a necessary first step the creation of a complete corpus of all epigraphic sources of the “Hittite textiles”, the first of its kind.The methodological approach will be based on a meticulous lexical and etymological investigation on verbal - noun paradigms referring to textiles in the Hittite world and professional titles.The primary objective is to create a comprehensive and useful dictionary of textile terminology of Hittite Anatolia.I will integrate my own academic background skills in Hittite language and philology with my host institution’s expertise in the fields of  experimental archaeology of ancient textile remains and tools.Thus, I will combine the information provided by specialists of the Centre for Textile Research  with the data which I will collect by analysing the Hittite textual documentation; not only administrative and economic texts, but also all those Hittite written sources that potentially describe the palace management of textile production, the accounts of weaving workshops (including terms for crafting and tools), the luxury goods as finished products (not only cloth, but also clothes and furnishings) and the textile items used in symbolic contexts. The comparative methodological approach is justified by the fact that ancient textiles rarely survive, not only in Anatolia, but also all over the ancient Near East and Mediterranean area, with the notable exception of Egypt. Fortunately the Scandinavian area provides many Bronze Age finds that have been already accurately analysed by Danish and Swe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The synthesis of tricholomenyns a and b - novel natural product with potential in cancer chemotherapy' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Two novel anti-mitotic natural products, named tricholomenyns A (b and B (@, have recently been . isolated from Tricholoma acerbum, a mushroom collected in Italy. The anti-mitotic activity of . tricholomenyns A (f and B (> was assayed in T Iymphocyte cultures treated as for cytogenic analysis. Anti-mitotic activity was observed at 0.16 pg/ml for the tricholomenyn B (2). The aim of this proposal is to develop synthetic routes to both tricholomenyns A and B which would also be useful for the preparation of simplified analogues for biological screening. The structure of the tricholomenyn A is novel but the nucleus bears a striking resemblance to bromoxone and a simple marine natural product recently prepared by Taylor and al. (L.N.P.S.-U.York). Initial studies will concentrate on the Sonogashira Pd/Cu catalysed coupling of bromoxone with a range of alkynes in order to obtain compounds 7 which should be submitted for biological screening. If problems are encountered with coupling to the highly functionalised nucleus 3, earlier synthetic intermediates, e.g 4 and 5, will be investigated in the process. We will also compare de reactivity of 3, 4 and 5 with the corresponding iodides. With the basic coupling methodology in place, we will proceed to investigate the synthesis of tricholomenyns A (O, starting from the 6-methyl-5-hepten-2-one. The proposed route to tricholomenyn B (2) is very similar. Two different approaches will be 5- investigated so as to prepare the cyclised compound 2: this may be possible via an intramolecular procedure or via a lactonisation. With synthetic routes to racemic material established, we will devise an asymetric sequence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'End of life decision making and life ending procedures in European intensive care units' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

OBJECTIVES:To determine the ethical and medical bases for decisions on withholding and withdrawing treatment in ICUs in Europe.To investigate how these decisions are made, how and whether there is communication between patients, families, physicians and other staff in making these decisions.To study which life-sustaining treatments are withheld or withdrawn and how this process takes place in the various countries.To determine how well, or not, the principles of beneficence, non-maleficence, justice, autonomy, its limits, consent and refusal, substituted/surrogate consent, moral interests applied in the context of the different legal, ethical and religious climates in the various countries.Major changes have occurred in the practice of medicine and today the majority of patients dying in the intensive care unit do so after the foregoing of life-sustaining treatments. There have been no large, prospective, multi-national studies of this problem and few of the published studies have been from Europe. The present project by the European Society of Intensive Care Medicine's working group on Ethics is a prospective study of end of life decision-making and life ending procedures in different European intensive care units. The study will determine who makes these decisions, whether there is communication and agreement between patients, families, physicians and staff in making these decisions, the reasons for the life-ending decisions, and finally determine the futility of intensive care for patients who are admitted with little likelihood of surviving or patients who remain in intensive care, despite the fact that physicians know they will die.All patients admitted to several intensive care units throughout Europe will be evaluated for dying after cardio pulmonaly resuscitatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeting DNA Damage Response and Metabolism for Precision Medicine in Rheumatoid Arthritis' (DDRAsTic) under Horizon Europe.

assistant: **Objectives**

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of people worldwide, and its negative health burden is accelerating in the ageing population. Despite many available treatments, up to 40% of RA patients do not respond sufficiently to current therapies and the needs for a precision medicine approach and new treatments are pressing. The complexity of RA and unselective mechanisms of action of existing drugs are challenges. Current treatments also have unintended adverse effects because they affect healthy cell types in the body. The proposed project “DDRAsTic” focuses on a particular enzyme called MTHFD2, which plays a crucial role in the metabolism of folate and DNA damage response of activated T cells. Recent research and preliminary data, suggest that MTHFD2 is overactive in RA patients. DDRAsTic aims to address the hyperactive T-cell responses at the core of RA by targeting MTHFD2 with novel inhibitors that spare essential components, thereby minimizing the risk of toxicity and adverse effects. In parallel, DDRAsTic seeks to understand the underlying reasons for the limited efficacy of current RA treatments and explore potential biomarkers that can predict how patients will respond to standard therapies, with a specific focus on understanding the involvement of MTHFD2. The aim is to introduce a precision medicine approach in RA and identify a novel treatment. To achieve this, DDRAsTic adopts a multidisciplinary approach and uses patient-derived specimens, RA animal models and bioinformatics analysis from large cohorts of RA patients to undergo advanced imaging, cellular and molecular techniques. Overall, these analyses aim to provide insights into MTHFD2's regulatory role in abnormal immune responses and advance RA treatment by introducing prec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Re-Exploring the Logic of Gandhian Violence: Gandhi and his Followers in the Quit India Movement, Bengal 1942-45' to be submitted under Horizon 2020.

assistant: **Abstract**

'Re-Exploring the Logic of Gandhian Violence: Gandhi and his Followers in the Quit India Movement, Bengal 1942-45 There is a need to bring back richly textured political histories which has now been largely abandoned by historians. This promises to be an exciting field because of new archival sources that have been released in recent years, especially in the context of Bengal. My post doctoral research proposes to study the Quit India Movement in Bengal, with special reference to the Tamralipta Jatiya Sarkar in Midnapore. I propose to study the movement with a threefold focus:1) Gandhi and the Quit India Movement: I wish to analyse Gandhi’s rationale behind the tacit incitement to violence just before the movement. It is not enough to say that Gandhi was in a militant mood during this time. What needs to be understood is how and why there was a change in his attitude towards the nature of a mass movement initiated by him. What implications did the call of ‘Karenge ya Marenge’ (‘Do or Die’) have for his already deeply entrenched philosophy of non-violent ‘action’? By acquiescing a different concept of ‘doing’ or ‘action’ wherein the ‘masses’ could be in control of their own actions and take to violence, was Gandhi forwarding a more diluted version of non-violence, which accommodated a degree of violence?  2) The Movement and Gandhi: How did a mass movement of such a scale, with definite violent overtones, conceptualise and internalise Gandhi as their undisputed leader, and carry out various acts of violence in his name?  What needs to be analysed is whether the movement was truly autonomous, organised by ground level Congress leaders, or was Gandhi, even as a distant figure in prison, in total control of the movement. Positive and assertive action, in this case necessita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mapping the brain with PET radiolabeled cannabinoid (CB1) ligands', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The development of innovative technology for the introduction of PET-radionuclides (18F, 11C, etc.) in organic compounds, as well as the identification of new radiolabeled molecules suitable for being used as PET tracers is one of the priorities in the areas of Applied Chemistry and Medical Technologies. First objective of this project is the identification of novel radiolabeled CB1 (cannabinoid) receptor ligands with an emphasis on the development of innovative synthetic methodologies for the introduction of 18F and 11C radioisotopes. These CB1 radioligands could be used at least in a couple of different ways. First to see whether the potential CB1 ligand makes it to the brain, where CB1 receptors are predominantly located, and what other organs sequester the drug. Second, to see how good is the affinity of the CB1 radioligands, an information that can be critical in dosimetry studies. The most promising and effective CB1 radioligands will be further investigated with the view of introducing chemical functions suitable for the development of multi-modal contrast agents for PET-CT, MRI, fluorescence and ultrasound. As an example, the radioligands will be functionalized with fluorescent tags, or chelating functions for paramagnetic metal cations for MRI use. The main goals of the project are (1) the identification of novel CB1 receptor radioligands with potential for clinical development, (2) a detailed study of their use for brain imaging, with the objective to use these PET-tracer molecules to visualize CB1-receptor related processes in the brain of animal models, with the future perspective of using these novel molecular tools as diagnostic tools in human brains. The partners in this project are (1) the University of Aberdeen (Scotland, UK), which is strong in the are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Humanoids with auditory and visual abilities in populated spaces' (HUMAVIPS).

assistant: **Concept**

Humanoids expected to collaborate with people should be able to interact with them in the most natural way. This involves significant perceptual, communication, and motor processes, operating in a coordinated fashion.  Consider a social gathering scenario where a humanoid is expected to possess certain social skills. It should be able to explore a populated space, to localize people and to determine their status, to decide to join one or two persons, to synthetize appropriate behavior, and to engage in dialog with them. Humans appear to solve these tasks routinely by integrating the often complementary information provided by multi sensory data processing, from low-level 3D object positioning to high-level gesture recognition and dialog handling. Understanding the world from unrestricted sensorial data, recognizing people's intentions and behaving like them are extremely challenging problems. The objective of HUMAVIPS is to endow humanoid robots with audiovisual (AV) abilities: exploration, recognition, and interaction, such that they exhibit adequate behavior when dealing with a group of people. Proposed research and technological developments will emphasize the role played by multimodal perception within principled models of human-robot interaction and of humanoid behavior. An adequate architecture will implement auditory and visual skills onto a fully programmable humanoid robot. An open-source software platform will be developed to foster dissemination and to ensure exploitation beyond the lifetime of the project.