RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Establishment of a european thematic network on emc for systems characterisation, measurements and compliance to standards' (1994-1998).

assistant: **Innovation**

Electrical and electronic devices, equipments and systems must be able to function satisfactorily in their electromagnetic (EM) environment, without introducing intolerable EM disturbances to anything else in that environment. Therefore, electromagnetic compatibility (EMC) should be an integral part of the production, design and development programme thus avoiding the need for expensive, less effective retrospective action. Compliance with the European EMC Directive (which will become mandatory on January 1996) requires that Industry has access to sophisticated EMC CAD tools of wide scope to predict the performance of particular systems. In addition, there are some aspects of EMC that need particular attention as they are not at presently understood to an adequate extent. These include, among other things, the testing of large systems, immunity resting and EMC in mixed systems (e.g., old/new thechnologies). Regarding Step's 2 implementation, the proposed EMC Network aims at the following that are of mportance to Industry, Community Policy and European Standards: - Indentification of potential emission problems early in the design cycle that can save money and speed time to market. - Development of an accurate procedure, which would allow the level of interference to be predicted for a selected system, thus ensuring high performance of the system. - Identification of reproducible tests for verification of EMC characteristics for specific industrial products that can avoid confusion and delays in properly qualifying such products, especially for compliance to standards. - Development of an accurate procedure for evaluating the effects of stressful electromagnetic environment on complex systems that would increase their reliability and survivability. In addittion, the prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High temperature and high pressure neutron and synchrotron diffraction studies of new high-tc superconductors' (1994-1998).

assistant: **Concept**

Research objectives and content As the field of high temperature superconductivity matures, it is becoming increasingly clear theat further progress, both in the design of new superconductors and in the understanding of the fundamental mechanisms, requires detailed knowledge of the way chemical and structural features relate to the superconducting behaviour. We will exploit the power of modern diffraction techniques to study two key contemporary studies of high temperature superconductors of scientific importance and which have several potential industrial applications. We will investigate both thallium and mercury based systems using structure characterization techniques. The first topic concerns the effect of pressure on the structural properties of the materials and the correlation of structural changes with variation in the critical temperature. Furthermore we intend to study the in situ formation as well as the structural features at high temperatures of this two superconducting systems. We investigate to show directly the formation of the different phases in this. The expected results will be of great use to both the design of new materials with higher transition temperatures and for the understanding of superconductivity based on crystal chemistry. Superconductors are widely used, especially as materials for the generation of high-field magnets. The new higher TC superconductors will make all these applications more accessible. Training content (objective, benefit and expected impact) During the proposed project I will extend my scientific experiences, listed in the CV attached, to aspects relevant for superconductivity. Furthermore I will become familiar with the specific requirements and used methods for the fabrication of superconducting devices with technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GABA A receptor subtypes: structure, function, distribution, and pharmacology' to be submitted under Fourth Framework.

assistant: **Abstract**

GABAA receptors, the major inhibitory neurotransmitter receptors in the brain, are ligand gated chloride ion channels that are formed from five protein subunits. The different, but overlapping regional distribution of the 15 GABAA receptor subunits so far identified in mammalian brain, indicates an enormous structural heterogeneity of these receptors. GABAA receptors, located in distinct brain regions, can modulate anxiety, convulsions, motor function, behaviour, cognition, vigilance and memory. A multiplicity of clinically important drugs, such as benzodiazepines, barbiturates, neuroactive steroids, and anesthetics, produce their action by non-selectively modulating most of the GABAA receptor subtypes via distinct allosteric binding sites located on these receptors. Compounds selectively interacting with individual GABAA receptor subtypes in different brain regions will avoid some of the side effects of these drugs and will have important therapeutic potential for the treatment of human diseases. Such compounds, thus, are of considerable interest for European society and industry. Development of compounds selectively interacting with specific GABAA receptor subtypes, however, is seriously hampered by the lack of knowledge on the subunit composition and regional, cellular and subcellular distribution of GABAA receptor subtypes in the central nervous system, and by the lack of information on the function of individual receptor subtypes in the brain. The present proposal aims to provide all this information by integrating the efforts of four highly recognized European laboratories with long standing interest in GABAA receptor research, that supplement each other by their different scientific background, working techniques and experimental approaches. Thus, the proposal is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'A Study of the Factors Determining Penetration of Polymethyl Methacrylate Bone Cement into Trabecular Bone'.

assistant: **Objectives**

Total joint replacement is a very successful operation, relieving pain and disability for approximately 1,5 million people worldwide each year. With changing demographic age distributions in the population, it is predicted that the need for such operations will increase significantly over the coming decades. Most implants use polymath methacrylate (PMMA) bone cement, which grouts the prosthesis into bone. A benchmark figure for survival to these implants is now 95% after 10 years. Even so, the number of revision operations is increasing, and themed for improved survival of the implants is very great. The predominant cause of failure is aseptic loosening, due to an inflammatory reaction at the interface between the cement of bone. However, data from roentgen stereophotogrammetric analysis (RSA) from the host laboratory and others indicates that early migration of the prosthesis is predictive of failure many years later. These observations suggest that failure of the initial fixation contributes to later failure. Pressurisation of cement is known to increase penetration of cement into orbicular bone and to provide good initial fixation. However, even at an anatomical site such as the femur, in which pressurisation is relatively easy to achieve, rapid variations in the viscosity of the cement during delivery can make it difficult to predict adequate cement penetration into bone. At other sites, such as the acetabulum (pelvis) and proximal tibia, it can be difficult to achieve significant pressurisation. The scientific proposal is, therefore, that a detailed study of the viscosity of bone cement, coupled with identification of specific surgical problems at particular anatomical locations, will significantly enhance initial fixation of implants. This study will investigate c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improved high fidelity Hydrodynamic Model for Floating Offshore Wind Turbine Analysis' (FloatingWindExcel).

assistant: **Concept**

The Floating Offshore Wind Turbine (FOWT) industry has rapidly grown from 2.3MW in 2009 to an impressive 15MW by 2023, with plans for larger 20MW and 25MW capacities. This growth poses challenges in cost, fabrication, manufacturing, and installation due to increased floater size and weight. Low to medium-fidelity hydrodynamic engineering models and higher safety factors are one of the reasons for this surge. High-fidelity models offer the most accurate representation of the underlying physics, minimizing approximations, however, they come with high computational costs. Our primary objective is to adopt high-fidelity CFD-based hydrodynamic models by significantly reducing computational time using the SWENSE and integrating them into aero-elastic solvers for FOWT analysis. This methodology involves decomposing the velocity field into incident and complementary velocity fields and solving only the complementary velocity field in the CFD domain, saving significant computational time. The developed solver will be systematically upgraded (four work packages) from single floating body to multi-body FOWT simulations. The resulting solver will play a pivotal role in unraveling the aero-hydro-structural behavior of FOWT systems during extreme wave interaction, fostering advancements in Operation and Maintenance research, and effectively addressing technical knowledge gaps in the FOWT field. There will be experiments to analyze boat-FOWT interaction as well as to evaluate the developed solver. My host institution runs the renowned Aeroelastic tool HAWC2, and my supervisor is a world-renowned expert in the numerical development of FOWT and physical model testing. He is well-suited to mentor this project with his expertise in both hydrodynamics and aeroelasticity. This endeavor will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Metallo-enzymes and Cells for Green Environmental Alternatives'.

assistant: **Concept**

"By far, nature is the best chemist of all time"" according to Nobel Prize winner Frances Arnold. McGEA will develop nature inspired strategies to help avert the pending climate catastrophe. We will discover, characterize, engineer and exploit metalloenzymes as potent biocatalysts to efficiently perform chemically challenging reactions of high environmental impact. Specifically, we will use metalloenzymes to tackle three burning issues that fall squarely in the remit of the EU Green Deal action plan: CO2 capture, (bio)hydrogen production, and wastewater monitoring and remediation. These challenges will be addressed using purified metalloenzymes incorporated into hybrid materials and live bacterial cells as self-regenerating catalytic metalloenzyme carriers. Implementation of these two strategies will proceed with research activities across the full pipeline of metalloenzyme development. This will include i) the assembly of the  metallic co-factors, as a prerequisite for establishing protocols for efficient metalloenzyme production, ii) rational redesign, directed evolution and in silico strategies to develop enzyme variants that show improved catalytic activity and stability, and iii) the incorporation of the enzymes into matrices that allow for enzyme reusability, stabilization, or their self-assembly into multi-enzymatic nanostructures for substrate channeling. The execution of this program relies on a strong interdisciplinary and intersectoral team. The McGEA brings together 6 research groups from EU and 2 research groups from overseas, all of them internationally recognized for their scientific excellence, and 3 EU companies that will join forces to accelerate the transition to a climate-neutral Europe. The consortium is designed to provide a diverse portfolio of sk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Overcoming barriers in estimating toxicity of arsenic species in seaweed' (SilhouetteOfSeaweed) under Horizon 2020.

assistant: **Objectives**

SilhouetteOfSeaweed will contribute to consumer’s safety by overcoming barriers in estimating toxicity of arsenic species in seaweed. The ocean covers 71% of the planet and for future sustainability the need for looking at using the ocean for food, e.g. seaweed, is increasing. Seaweed contains high amounts of arsenic, including arsenolipids (AsLp). Recently the first data on AsLp toxicity have elucidated that they are as toxic as the most toxic arsenic, the inorganic arsenic (iAs). There is a lack of data on AsLps in seaweed products for human consumption. Safety of seaweed must be addressed and more studies and information on AsLps are urgently needed. Currently, only few research groups worldwide work on AsLps, partly due to difficulties associated with the measurements of these compounds. SilhouetteOfSeaweed will expand this expertise in Europe by establishing necessary facilities at the host Matís to accommodate AsLp measurements. Matís has the capacity to reach this goal together with the experienced researcher and in co-operation with a European partner organisation with expertise in AsLp measurements. SilhouetteOfSeaweed will have two main scientific impacts. Firstly, it will produce AsLp seaweed profiles in 4 different species of brown algae in 3 locations during 3 seasons in Iceland. This information will contribute to the necessary risk assessment needed for algae used for human consumption. Secondly, statistical evaluation and comparison of environmental conditions will make it possible to identify whether the seaweed could be harvested at specific conditions where the amount of toxic arsenic is at its lowest. These data are essential for SMEs entering the European market with their seaweed products. Moreover the project will impact the career development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spatio-Temporal Regulation of Inflammation and Tissue Regeneration: Studying the immune system - tissue - microbiota communication to develop targeted therapies for immune-mediated diseases and cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Inflammation is fundamental to promote tissue regeneration upon injury, and in turn, the resolution of the immune response. Physiological tissue regeneration depends on fine-tuned interaction between the immune system, the tissue, and the microbiota. However, the complex communication between these three components and the molecules that mediate it are unclear. Understanding this is fundamental to prevent immune-mediated diseases and even cancer. This is particularly important at mucosal surfaces, where continued regeneration occurs. Therefore, we hypothesize that inflammatory bowel disease (IBD) and colorectal cancer (CRC) are a consequence of a miscommunication between these components. Interleukin-22 (IL-22) is one key orchestrator of this communication: It is produced by immune cells and by acting on intestinal epithelial cells, it modulates the composition of the microbiota and promotes tissue regeneration. However, IL-22 can also promote both chronic inflammation and cancer. Exactly what regulates these paradoxical effects remains unclear. Of note, there is an endogenous inhibitor of IL-22, namely IL-22 binding protein (IL-22BP), which blocks IL-22 activity. We hypothesize that a misguided spatio-temporal regulation of the IL-22 – IL-22BP axis is the cause of pathogenic effects of IL-22. In particular, we will analyse: (i) the location, and the functional and molecular heterogeneity; (ii) the origin and fate of IL-22 and IL-22BP producing immune cells; and (iii) the role of the microbiota in regulating them. To this end, we will use new transgenic and gnotobiotic mouse models, single cell RNA sequencing and human samples. In short, by studying the IL-22 - IL-22BP axis, we will understand how the complex interactions between the immune system, the tissue, and the m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cloning of genes which encode aba-related dna binding proteins using the yeast one-hybrid system' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The resurrection plant Craterostigma plantagineum is being used as an experimental model system to dissect pathways leading to desiccation tolerance. This plant responds to desiccation with complex metabolic changes resulting in the synthesis of many new proteins. During drying treatment novel gene products accumulate rapidly in leaves or other tissues. Several of these genes have been demonstrated to be regulated by abscisic acid (ABA). In order to understand desiccation tolerance in higher plants a major goal is to isolate genes and determine parameters which regulate the expression of the response genes. One approach has been the analysis of ABA and desiccation inducible promoters and the subsequent characterization of DNA binding proteins which confer ABA responsiveness to the structural genes. A novel technique by which this can be achieved is using the yeast one-hybrid system which has recently been established and improved at MPI by the group of Dr.Thompson.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Real-time in Situ detection of strontium-90 in water: ultra-sensitive detector system for continuous monitoring of groundwater and nuclear facilities' to be submitted under Fifth Framework.

assistant: **Abstract**

Radioactive contamination is one of the most urgent environmental problems. In Europe, the Arctic is the most critical region, with a huge load of dumped radionuclides. Strontium-90 (Sr-90) is the most dangerous nuclide, because it enters the human food chain and is incorporated in the bones, where it remains for life, due to its lifetime of 28 years. Liquids like water and milk are the main vectors for Sr-90 intake, but no on-line in situ analytical instrument exists to monitor contamination near the Drinking Water Standard. The proposed Sr-90 detector is based on novel multi-channel photomultipliers, allowing to construct instruments of low weight and low power consumption, capable of on-site remote controlled and solar-powered operation. Above detectors are ideal for monitoring nuclear facilities, to raise instant alarm in case of leakage and are needed in long-term remediation efforts, such as removal of Sr-90 from groundwater.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'On line structure monitoring by laser ultrasonics for process control in rolling and heat treatment' under Fourth Framework.

assistant: **Concept**

The industrial objective is to improve yield and reduce processing costs in rolling and heat treatment operations for a wide range of ferrous and non ferrous alloy families by process control based on on line metallurgical structure monitoring. This will increase the competitiveness of the metal processing industry, decrease energy use and improve the quality of products. The main technical objective is to research, develop, demonstrate and validate measurement instrumentation based on non contact, laser ultrasonics for determining microstructural parameters crucial to process control and product quality. These include grain size, recrystallisation state, phase content and solution state. The technical and economic feasibility of exploitation will be assessed by kialsilot or production plant for hot and cold rolling of steels and copper and solution treatment of nickel alloy castings. These will be carried out by metal producers from 4 countries of the EU and will serve as demonstrators of the feasibility of application to a wider range of processes and alloys. The end users will be supported by research organizations bringing special skills in applied physics, microstructural characterization and modeling, non destructive testing, and process metallurgy to the interrelated tasks. The project brings together new scientific and technical developments resulting from current national investments, to provide the springboard for improved energy efficient materials processing. Prime deliverables will be the demonstration of innovative microstructural monitoring hardware and software for the above range of processes. Anticipated economic benefits are estimated to be in the range 0.1 1 MECU/metallurgical plant/yr. Energy savings from a 1% yield improvement in hot rolled steel p