RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Placenta-expanded adherent stromal cells (PLX-PAD) as an innovative therapy for improving recovery and survival following hip fracture arthroplasty – HIPGEN, a multicenter phase III trial'.

assistant: **Innovation**

Aim of the HIPGEN project is to develop the first cell therapy to improve functional recovery following hip fracture arthroplasty. Hip fractures are a major public health concern in the EU with an increasing incidence of 1 million patients per year, high direct and indirect costs and high mortality. Conventional therapies are not able to address the main medical problems of hip fracture in these elderly patients, being the impairment of mobility and the stress imposed as a combined result of injury, surgery and immobilisation. PLX-PAD are an allogeneic, placental-derived, stromal cell product and currently the only Advanced Therapy Medicinal Product (ATMP) in phase III in this indication. Based on comprehensive preclinical work on the effect of PLX-PAD on muscle regeneration after injury, a phase I/II study under the collaboration of Pluristem and Charité demonstrated an increase in muscle force and volume in hip arthroplasty patients and a reduction of early postoperative stress. We plan to conduct a multicentre, randomised, double blind, placebo controlled phase III clinical trial evaluating the efficacy of intraoperative intramuscular injections of PLX-PAD for the recovery of hip fracture patients. The clinical study will include biomechanical analyses and in-depth biomarker studies of treated patients analysing the effects of the cells on the immune system and individual stress reactions aiming at stratifying patients in future therapies. Further preclinical characterisation of the mechanisms of action of PLX-PAD in injured patients will be conducted. The “Be the Partner” platform will be used to improve patient experience in the trial, and create a strategic patient engagement beyond the trial. In addition to renown experts in hip fracture, cell therapy and immunol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identifying molecular mechanism responsible for spatial reorganisation of the genome during embryogenesis' (IMMRSRGE).

assistant: **Concept**

Spatial organisation in the nucleus is not random and it has a role in genome regulation. Large blocks of heterochromatin accumulate at the nuclear envelope and positioning of genes at the nuclear periphery correlates with gene repression. However, this organisation is not fixed and nuclear reorganisation has been described during mammalian development. In the inner cell mass of the blastocyst, chromatin exists in an unusual configuration with apparently widely dispersed open chromatin fibres. Following implantation at the epiblast stage, several hundreds of genes relocate to the nuclear periphery, concomitant with the formation of large domains of heterochromatin there. Interestingly, in the same time, specific genes can also remove from the nuclear envelope to the centre of the nucleus which is associated to their activation. Subsequently, lineage-dependant changes occur during the next steps of development. However, the molecular mechanisms which control this reorganisation are not understood. Prevailing models assume some transacting factors are responsible for an active recruitment and tethering of specific domains to the nuclear envelope. Thus, I propose, using a candidate approach and a RNAi screen, to identify factors responsible for the nuclear reorganisation observed in EpiSCs and to also address an alternative hypothesis that I have proposed and which involves a more passive accumulation of heterochromatin at the nuclear periphery that is influenced by nuclear pore complexes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single-cell phylogenomic exploration of archaeal dark matter' (DARKCELLS).

assistant: **Concept**

While the archaeal domain of life was discovered more than 30 years ago, the biology of archaeal organisms remains to be relatively obscure, especially when compared to that of bacterial and eukaryotic life. Yet, despite the limited knowledge regarding their lifestyle and ecological relevance, evidence is mounting that certain archaea play key roles in global nitrogen and carbon cycles. In addition, archaea share a common branch in the tree of life with the eukaryotes, and have most likely played a prominent role in the emergence of the eukaryotic cell, and thus of complex life. Interestingly, recent ecological surveys have started to reveal a hidden diversity of archaeal life. The exploration of this supposed ‘archaeal dark matter’ might thus hold relevance for a number of fundamental issues and reveal profound insights about the diversity, ecology and evolution of the archaeal domain of life. Unfortunately, characterization of these uncultured lineages is procrastinated by limitations in cultivation techniques and limited availability of genetic tools, urging for the exploration of alternative strategies to do so.Here I am proposing to utilize a single-cell phylogenomics approach to explore novel archaeal lineages at the genomic level. Habitats hosting novel archaea will be sampled and single-cell genome sequencing will be performed using next-generation sequencing technology. The proposed strategy will result in (1) obtaining a better sampling of archaeal genomes, (2) gaining insight in the evolutionary history of the archaeal domain of life through phylogenomics, and  (3) obtaining information regarding the biology and lifestyle of these novel archaeal lineages. This work will dramatically increase the number of archaeal genomes available in public databases for bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ProZero - carbon based fast boats for professional use' (ProZero) targeting Horizon 2020.

assistant: **Abstract**

Tuco Yacht Værft ApS (TUCO) aims to pursue a major market opportunity by developing and commercializing carbon fibrefast boats for professional use based on a flexible and simple production platform.Carbon excels from the other materials, especially due to the highest strength/weight relationship, which among others,results in: savings on fuel, significant reduction of greenhouse gas emissions, larger operational range or faster boats.Although carbon has been successfully deployed in other vessel types, such as fast ferries, recreation and high-end racingyachts, the usage of carbon remains unproved in the market of fast boats for professional use. The commercial shippingindustry is very conservative and it is thus necessary to demonstrate the benefits of carbon fibre in the targeted marketbefore large-scale commercialization.With ProZero project, TUCO will overcome prevailing market and entry barriers by partnering with key stakeholders andbuilding solid reference cases. In addition, we will offer a full product range – the ProZero boat series - that can be built toorder on a simple platform (using same tools) reducing the required initial investments of the whole series. Theaccomplishment of the project objectives will represent a significant business opportunity for TUCO, with an expectedturnover of 23 Mio EUR, 5 years after commercialization.The SME instrument funding plays an important strategic role in the future business development of TUCO. After assessingthe feasibility of ProZero in the SME phase 1 project, we intend to pursue our strategic vision of introducing a new line of fastboats for professional use to the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Markov Test Logic - Automated Statistical Testing Suite for Software Validation'.

assistant: **Concept**

The MaTeLo project aims at developing a statistical testing suite able to manage optimal test campaigns for software validation. The suite will include:- an automatic generator of test cases (derived from a Markov chain) based on stochastic methods;- Test execution modules, results analysers to generate quality reports;- Metrics to accurately evaluate software reliability and performance.End-users from automobile, telecoms and aeronautics will integrate the testing tools for validation. They expect from MaTeLo:- to increase and to manage software reliability;- to better control the schedule, to reduce the time to market;- to globally decrease development costs.Objectives:The project aims at developing a statistical testing suite able to manage optimal test campaigns for software validation. This is particularly relevant for the design of embedded systems (automobile, aeronautics, telecommunications):- Investigations on standard formal specification languages for the different industries specifications simulation methods and associated tools;- Development of an automatic generator of test cases (derived from of Markov usage model) based on stochastic methods;- Test execution in heterogeneous environments, test results analysis and quality reports generation for regular follow-up during the development;- Development of metrics to accurately evaluate software reliability and performance, all along the development process;- Integration of the testing tools in real development environments for industrial validation.Work description:To achieve its objectives, this 30-month project has been divided in 9 work packages:- Technical Specifications : requirements from the end-users, preliminary investigations;- Markov model generation : investigations of methodologies to automatica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Collaborative European effort to Develop Diabetes Diagnostics'.

assistant: **Objectives**

CEED3 (Collaborative European Effort to Develop Diabetes Diagnostics) has as its central objective, the development of diagnostic tools to differentiate specific subgroups of diabetic patients to allow individualisation of patient care. CEED3 will achieve this by integrating basic science findings from animal models, cell studies, and large scale genetic studies with clinical observations and testing of patients’ phenotype. The development of diabetes diagnostic tools will involve a clearly defined process of discovery of potential novel genetic and non-genetic biomarkers, validation within test and population based data samples, development of a clinical application and then dissemination of this application. The areas of focus for the diabetes diagnostics will be three areas where there is potential for considerable improvement in care and reduction in the burden of diabetes: the identification of patients with specific subgroups of monogenic diabetes, the identification of non diabetic and diabetic subjects with initial pancreatic beta-cell dysfunction at high risk of rapidly deteriorating glycaemia and the detection of diabetic patients at increased risk of vascular complications. For each of these patient groups the identification of the subgroups will result in improved clinical care by allowing treatment to be tailored for the individual patient. Therefore, the goal of this proposal is to make a rapid translation from scientific discoveries to improved care for diabetic patients. CEED3 has assembled the best researchers, clinical samples and technical expertise in Europe to realise this goal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding the functions of the BRCA protein complexes in DNA break repair and in replication stress' under Horizon 2020.

assistant: **Concept**

BRCA1, BRCA2 and associated factors are frequently mutated in familial and sporadic cancers of the breast and ovary. The BRCA proteins have canonical functions together with the RAD51 recombinase in DNA double-strand break repair by homologous recombination. More recently, it was discovered that the same proteins have separate, recombination-independent roles in the metabolism of challenged replication forks. It is currently debated whether defects in the canonical and/or non-canonical functions of BRCA contribute to tumorigenesis. As BRCA1 and BRCA2 function in various processes, interact with numbers of co-factors, and can be extensively post-translationally modified, phenotypes associated with their defects are often very pleiotropic. Here I propose to use a biochemical approach, which will allow us to study the precise functions of these proteins with defined substrates and co-factors in controlled systems. BRCA1 and BRCA2 represent some of the largest factors in human proteome. Using state-of-the-art protein expression strategies, we are now able to produce sufficient quantities of the respective complexes in their native or post-translationally modified states to make biochemistry feasible. We aim to define how the BRCA proteins help couple the initial steps in DNA break repair including nucleolytic processing of DNA breaks, RAD51 loading on ssDNA and subsequent invasion of homologous DNA template. We will also determine the precise non-canonical functions of RAD51, RAD52 and BRCA1/2 complexes in fork remodeling, fork protection and fork restart, which prevents pathological degradation of nascent DNA under replication stress. We anticipate that these diverse functions of BRCA proteins are governed by their co-factors, post-translational modifications and specific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pattern formation induced by elastic stresses and geometrical constraints' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In this project we intend to study the interplay between mechanical stresses and the global geometry in different systems which give rise to formation of complex patterns. One such system regards the packing of 1D objects, such as ropes, in 3D containers s uch as spheres. Another such system is a network of cracks whose evolution is coupled to the global geometry of the material they fragment. Last, we intend to study the existence and properties of slip pulses which allow two solids to slide one on another with hardly any friction, where here too the microscopic dynamics of the slip pulses are coupled to the global geometry of those solids. This is a theoretical research with impact on a wide range of experimental fields, such as the growth of crack networks , the packing of viral DNA in capsids, propagation without (almost any) friction and earthquakes. In all of these examples there is interplay between small-scale interactions and some large-scale constraints which lead to complex structures, and to non tri vial dynamics. The Fellow is an exceptionally successful PhD graduate with 11 published papers. The training agenda is principally to broaden his range of techniques and fields of application, and to develop his international profile. The Host is a major F rench training and research institution where the exact sciences are concentrated in one building, and with many more relevant research labs in nearby institutes, providing a unique focus for this research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mixed field dosimetry and NCT treatment planning' to be submitted under Sixth Framework.

assistant: **Abstract**

Transfer of knowledge and research of the project concern mixed high-and low-LET radiation dosimetry with special attention to its application in neutron capture therapy a binary treatment modality based on nuclear reactions initiated by capture of thermal neutrons by initially non radioctive nuclei with high cross section for such a capture. At present, the reaction with boron atoms (10B) is used for so called boron neutron capture therapy (BNCT). In this case, a boron nucleus captures thermal neutron producing an alpha particle and 7Li ion.After 10B has been delivered selectively to tumour cells, it can be activated by neutrons to deliver locally lethal high-LET radiation. Tissues exposed to neutron beams are subject to a mixture of absorbed dose components. The most important components in tissue can be identified as photon dose, fast neutron dose and absorbed dose due to capture reactions notably in nitrogen and, in the case of BNCT, neutron capture also in boron.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards a 10-Year Vision for Global Research Data Infrastructures' to be submitted under Seventh Framework.

assistant: **Abstract**

A Vision for Global Research Data Infrastructures GRDI2020 aims to define a framework of technological, organizational, & policy recommendations to guide the development of an ecosystem of Global Research Data Infrastructures. The project activities are aimed at mobilizing user communities, international initiatives, leading experts and policy makers worldwide in the GRDI2020 plan.GRDI2020 is submitted at a crucial time since large data infrastructures have been developed that require integration onto a new expanded Global Data Infrastructure. The current 4 strong consortium from IT, UK, GR & SE was instrumental in the results achieved at 3 prior GRL2020 meetings in: US,'07; Europe, IT,'08; Asia, TW,'09 to take forward in a coordinated approach.GRDI2020 leads as an obvious follow-up to these events to ensure a sustained action to serve an international forum for all European and global major initiatives for the purpose of presenting, discussing & tackling the major issues in the development of a sustainable Global Research Data Infrastructure.GRDI2020 major results:A Roadmap Report addressing the application, technological and organizational issues involved in the development of a sustainable Global Scientific Data Infrastructure.Working Group (WG) meetings offering a forum for focused discussions concerning technological, organizational and application aspects of Research Data Infrastructures.Thematic Reports and whitepapers on user requirements, technological and policy aspects of Research Data Infrastructures.Analysis Report containing an in depth analysis of policy documents on information infrastructures produced by funding agencies, ad-hoc committees, and scientific organizations worldwide.GRDI2020 will operate 2 active WGs of leading external expert collaborators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimization of Radiation Protection of Medical Staff' (ORAMED).

assistant: **Concept**

The state-of-the-art analysis performed in the FP6 CONRAD project highlighted high extremity doses and a lack of systematic data analysis on exposures to the staff in interventional radiology (IR) and nuclear medicine (NM). To optimize the working procedures in the medical field with respect to radiation protection, a project focussed on improving the knowledge on extremity and eye lens exposures is proposed, combined with an optimization in the use of active personal dosemeters.  The first objective is to obtain extensive extremity dose data for staff in IR, with special attention to eye lens doses and the analysis of the radiation protection measures. At the present time there is no suitable dosimeter for eye lens dosimetry. Hp(3) is mentioned as the operational quantity to control the dose limits, but there are no conversion coefficients nor a calibration procedure available. The second objective of the project is to develop a formalism to measure eye lens doses and to design a prototype eye lens dosemeter. IR staff belongs to a specific working group which could benefit from a real time accurate dose assessment. Therefore, the third objective is to study the behaviour of commercial active personal dosemeters under real conditions and to design a prototype that could solve the present problems. In NM the doses to the different parts of the hands will be systematically mapped, with special attention to unsealed therapy sources, aiming to estimate the real dose load of NM workers and to describe appropriate protection measures. The different objectives of this project will be achieved through well coordinated measurement campaigns in European hospitals. Simulations will be performed to determine the main parameters that influence the extremity and eye lens doses and th