RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Island ecosystem ecology from deep prehistory to the Anthropocene' (ISLANDLAB) under Horizon Europe.

assistant: **Objectives**

Humans are fragmenting ecosystems into habitat 'islands', causing an unprecedented global collapse of large mammal populations just as science is discovering their essential ecological roles. The impact of these losses is such that our understanding of the contemporary biosphere is clearly shaped by a world artificially depleted of terrestrial giants. However, the causes of megafaunal extinctions over a much deeper, >50,000-year timeframe remain strongly contested. How did specific anthropogenic and/or climate factors interact to transform and collapse megafaunal ecosystems and what implications did this have for human societies at different points in time? The feedbacks and ecological legacies of these older extinctions have important lessons for the current biodiversity crisis, yet the dearth of good quality fossil and contextual data from many regions, settings and species has prevented robust appraisal. ISLANDLAB will explore these questions using the Maltese Islands as a frame of reference for the effects of anthropogenic ecosystem fragmentation. Pilot work has already uncovered an unprecedented deep-time record of pristine natural systems successively interrupted by waves of humans. Direct interaction between humans and the endemic megafauna begins with a likely Neanderthal presence and ends with the first monumental civilizations, with exponential losses and subsequent faunal reintroductions lasting until the mid-Holocene. By building high-resolution ecological, climatic, and archaeological characterisations of Malta before and after human arrival and subsequent alteration of biotas, ISLANDLAB will therefore document long-term legacies and feedbacks between ecological changes, societal responses, and ecosystem resilience. More broadly, the results will shed light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functional brain networks in epilepsy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This proposal for a Marie Sklodowska-Curie Global Fellowship is meant for the training of Dr. Pieter van Mierlo, currently at Ghent University, in the Functional Brain Mapping Laboratory (FBM Lab) of the University of Geneva, one of the world leading brain imaging laboratories. The goal of the project is to explore the communication between brain regions in epilepsy patients to ameliorate their treatment.  In the first stage a non-invasive tool, ElectroEncephaloGraphy (EEG), will be used to measure the electric field of the brain through electrodes placed on top of the scalp. By measuring the voltage difference between the EEG electrodes the electric field of the brain can be studied with a high temporal resolution (ms). Recently, high density EEG (hd-EEG) systems have been developed with up to 256 electrodes. These systems allow more accurate measurements compared to the old systems having only ± 32 electrodes. The FBM Lab is one of the few labs that have hd-EEG recordings of epilepsy patients. In this project we will develop an algorithm to investigate the brain networks in epilepsy patients based on hd-EEG recordings. The brain networks will be studied to localize the epileptic focus, the brain region that causes the seizures. In the second stage hd-EEG will be combined with functional Magnetic Resonance Imaging (fMRI) that images the concentration of oxygen in the brain with a high spatial resolution (mm). The simultaneously recorded hd-EEG / fMRI allows studying the brain networks with both a high temporal and spatial resolution. Furthermore, fMRI is more sensitive to record brain activity of deep brain structures compared to hd-EEG. The added value of combining hd-EEG with fMRI to localize the epileptic focus will be assessed.In the third and final stage, the deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis of the role of splicing and cis-acting elements in oskar mRNA transport in the Drosophila oocyte' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Pre-localization of maternal mRNAs coupled with spatio-temporal regulation of translation is a notable feature in the early development of many organisms. In Drosophila, oskar, the posterior determinant of the embryo, is localized in RNP particles to the posterior pole of the oocyte and its expression is regulated by localization-dependent translational control. The mechanisms regulating RNP assembly and transport to posterior pole remain largely unclear. Recent studies have revealed that splicing and proteins of Exon Junction Complex are required, indicating a role of nuclear history in oskar mRNA targeting.Through a combination of molecular genetic and biochemical approaches I propose to analyse the role of splicing in oskar mRNA localization and to identify the cis-acting elements in oskar mRNA that are critical for oskar RNP particle assembly in vitro and in vivo. Further, the study aims to investigate the molecular architecture of the mRNP complex and to define the complement of protein(s) critical for assembly of the oskar mRNP. I shall test the hypothesis that the earliest interactions among nuclear proteins and the RNA direct the oskar RNP complexes to posterior transport pathway by recruiting specific localization factors.An insight into the mechanism of polarity in Drosophila can be extended to understand this fundamental process in diverse cells and organisms. The proposal makes use of the multidisciplinary and highly interactive research environment at EMBL. The host lab has made pioneering contributions in the area of oskar mRNA localization and translational control in the Drosophila oocyte. This research proposal is at the centre of their present line of interest. Further, the advanced training received at EMBL will help me in shaping a successful indepen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'WATTsUP Electric flight to future' (WATTsUP).

assistant: **Concept**

The aim of “WATTsUP – Electric flight to future” project (hereafter: WATTsUP Project) is to industrialize and commercializeour newest prototype plane – WATTsUP PROTOTYPE, which was first presented to public at Salon de Blois airshow,France, on 30-31 August 2014:• https://www.youtube.com/watch?v=OEeR7osnRSk• https://www.youtube.com/watch?v=2Yo3puYqaNs&list=PLShcsPdd5Fc9Jz73qEhp9O3MKkcFQrmd8Final product of WATTsUP Project is market and production-ready electrical powered airplane of LSA class: WATTsUP.Main project activities will:- Evolve existent WATTsUP PROTOTYPE to industrial readiness, resulting in fully functional and cost-effective LSA,accompanied with documentation and training information system (interactive training system + flight school managementsystem).- Prepare WAATsUP for commercialization.- Develop production processes, enabling Pipistrel to enter into mass production of WATTsUP.- Certificate WATTsUP in our initial target-markets.- Decide on the fesibility and type of IPR protection.- Disseminate project results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'How epigenetic reprogramming modulates 3D chromatin organization in totipotent embryos', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

One of the most intriguing questions in biology is how a single cell (zygote) is generated that has the potential to give rise to all cell types of an organism, known as totipotency. The overall purpose of this project is to gain mechanistic insights into the establishment of the totipotent state, in terms of 3D chromatin organization and zygotic genome activation (ZGA), summarized in two key aims:i)To test whether and how epigenetic reprogramming modulates the 3D chromatin structure in zygotes: The generation of a zygote is accompanied by Tet3-dependent active DNA demethylation of the paternal genome and asymmetry in histone modifications between the parental genomes. Whether this alters chromatin organization and promotes transcription is poorly understood. To test this, I will perturb Tet3 activity and perform single nucleus Hi-C (snHi-C) of zygotes to determine changes in genome architecture. In addition, I will study the effect of the absence of Kdm4a on the different histone marks and the consequent potential effect on chromatin architecture. This work will provide the first insights into how epigenetic reprogramming alters chromatin organization. ii) To study the mechanism of ZGA: The activation of embryonic transcription is crucial for the development of an organism. However, the essential activators of ZGA in mammals remain largely unidentified. Based on work in Drosophila, a leading hypothesis is that ZGA is triggered by pioneer transcription factors. To identify these, I will participate in a targeted knockdown screen in embryos to identify factors required for ZGA. I will focus on one potential candidate and generate transgenic mouse strains to study its function in early embryos. This high-risk high-gain aim has the potential to identify novel regulators of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neurotoxic effects of methyl-mercury in the neocortex of the rat : cellular electrophysiological and mutagenicity studies' (1994-1998).

assistant: **Innovation**

Foreseen ResultsAs an advantage of the planned collaboration between the 5 laboratories in the frame of the present project, the different methods applied would increase the effectiveness of the diagnosis of subclinical damage to the nervous system in chronic mercury intoxication.The following questions will be investigated :the development of sensitive methods to detect neurotoxic effects in neocortical cells,the study of the sequential expression of toxic effects : (cyto-) genetic endpoints versus cell death (apoptosis) versus neurophysiological changes,the analysis of chronic low level and transplacental exposure to environmentally relevant pollutants on electrophysiological functions of mammalian neocortex at cellular and network level in adult and developing nervous system,the analysis of the effects of MMC intoxication on the initiation, maintenance and propagation of epileptiform activity of the neocortex,the role of different kinds of excitatory aminoacid receptors (NMDA and non-NMDA, AMPA receptors) on the initiation, maintenance and propagation of epileptiform activity of the neocortex in MMC intoxicated animals,effect of MMC exposure on metabolism, convulsant activity and neurotoxicity of kynurenic acid.The alkylmercury compounds, especially methylmercury (MMC), are the most dangerous and common sources of mercury toxicity, because of both their widespread use as fungicides and the fact that methylmercury is made by bacteria from elemental mercury. The principal sites of mercury deposition is the central nervous system, after exposure to alkyl mercury compounds which are highly accumulative. The general health condition of the population is influenced by mercury intoxication, which is indicated by an increased probability of epilepsy. However, the exact neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development and in vivo validation of a SPION based Theranostic nanosystem for the treatment of Metastatic Breast Cancer'.

assistant: **Objectives**

This project aims to develop a Theranostic Nanosystem allowing selective co-delivery of therapeutic agents with distinct physical chemical properties to target diseased cells in vivo. Besides good on-shelf and in vivo stability and low toxicity, the system must enable ratiometric control of cargo loading, avoid premature release of transported agents, allow controlled drug release at targeted locations, and its real-time, non-invasive, monitorization in vivo. Although adaptable to other applications, the system here will transport two chemotherapeutic drugs (Doxorubicin and Cisplatin), one RNA (antagomir-10b) and one peptide (H5WYG), coated with PEG-folate conjugate to confer both stealthness and cell specific tropism to the whole. The nanosystem will be fabricated, characterized in vitro and optimized, and the function of each component will be examined in cultured murine Metastatic Breast Cancer 4T1 cells. The latter forms highly aggressive metastatic tumors in immune competent BALB/c mice that recapitulate the human disease. 4T1 overexpresses folate receptor, which will interact with the system and induce its internalization through the endosomal pathway. These cells are sensitive to doxorubicin and cisplatin, and their metastatic character is inhibited by antagomir-10b. Whilst chemotherapeutic drugs escape the endosome by simple diffusion, escape of antagomir-10b from will be facilitated by an endosomolytic peptide co-transported by the system. Acidification of the endosome will trigger drug release and endosomo-lysis. The correct functioning of the system should inhibit metastatic spreading of 4T1 cells in mice and kill primary and secondary tumors, offering an ideal model to optimize performance. A Superparamagnetic Iron Oxide core will allow in vivo monitorizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Sociology of Authoritarian Law: Insights from Central Asia'.

assistant: **Innovation**

The overarching objective of the SOCIAL is to contribute to global and national efforts in understanding and addressing the challenges associated with promoting democratization and good governance in authoritarian contexts.  More specifically, SOCIAL is built around three interconnected goals: 1. To collect original empirical data and produce new theoretical and empirical insights on the interplay between law, society and governance in authoritarian regimes in the Central Asian context. The empirical findings will enable us to engage with and advance theoretical debates within (comparative) political regimes literature and authoritarian law/legality scholarship.2. To create, develop and enhance the sustainability of doctoral training programmes focused on the study of authoritarian regimes. Our proposed programme will involve a variety of disciplines, sectors, fields and geographical regions. By doing this, we will equip doctoral candidates with a comprehensive understanding of the interplay between law, society, and governance in authoritarian regimes, which will be embedded in the novel theoretical and methodological approaches.3. To engage with and contribute to the global democratization and good governance agenda by translating research findings into policy-relevant ways and providing strategic intelligence and policy insights for international organisations, development agencies, decision-makers, researchers and practitioners inside and outside the EU on ways to promote democratization and good governance in authoritarian contexts. These goals will be accomplished by designing and conducting interdisciplinary and multisectoral doctoral networks programme on the “sociology of authoritarian law” involving 17 doctoral candidates, each completing a PhD at one of the 1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multidevice software platform for caring elderly patients at home' in the context of a Horizon 2020 call.

assistant: **Objectives**

Eldercare services at home have been pointed as a promising field with great potential to generate new business opportunities for the ICT industry. European health and telecare services already cover basic needs and are really well-ranked but, will Europe be ready for the demographic explosion of these needs at patients’ home? How will ICT technology help Europe to keep the health and telecare systems sustainable?.The final goal is that elderly people or patients can be cared at home preventing all emergency situations that end in hospital admissions and making telecare services sustainable for an increasing number of end users. Unfortunately, up to now the achievement of these objectives have been hampered by the limited functionalities of the ICT solutions and the high price of advances technical devices used by the eldercare service providers.Ideable has developed Kwido, an accessible and user friendly platform for elderly users and utilities focused on their needs and their caregivers’ demands, being the most accessible and usable solution for the growing eldercare market. Currently available Kwido platform is designed for being used mainly by carers at daily centres or in nursing homes. KWIDO@TELECARE, an advanced version of Kwido with new key features, will be the most complete, flexible and revolutionary platform for caring for elderly patients at home, focused on the telecare service providers and their clients (public and private institutions) as customers. It will have a direct impact not only in the global economy, but also in the society, and at the same time will lead Ideable to consolidate itself as a worldwide reference provider of software based telecare and prevention ICT solutions for the elderly.Ideable has already developed all novel features for KWI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Social equity goals in conservation interventions: a system thinking approach to track progress at global level' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The rapid decline of the planet’s biodiversity has prompted governments to adopt an ambitious target to halt the loss of biodiversity and ecosystem services by 2020 through the expansion of protected sites, the Aichi Target 11. Despite this target includes the commitment to reach equitable protected sites that should do no harm local people, we still do not have an adequate way to track progress towards achieving equity in conservation interventions. Global indicators are ineffective in capture the complexity and interactions of multiple factors influencing well-being of local communities. The evidence from case studies at local level show ambiguous conclusions that provide little support for broader scale decision making due to the lack of agreed conceptual understanding and standardized methodologies. The aim of this project is build up an innovative methodological approach to track global achievement of equity in conservation interventions from cases studies. This project employs system thinking methods to conceptualize equity in conservation interventions as a dynamic system. This project will gather the scattered information from multiple datasets and case studies and bring them into this system to simulate their behaviour over time by modelling tools. The project will be hosted by an interdisciplinary group, integrating the methodological expertise on conservation interventions and modelling of the CMEC, with the experience analysing governance regimes and politics issues, economic and livelihoods strategies of IFRO, at the University of Copenhagen. The project will focus on policy relevant analyses, taking advantage of a strong collaboration with the WCMC in UK for communication and implementation of outcomes. The outcomes from this project will comprise the firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cargospeed cargo rail road interchange at speed' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

CargoSpeed - Cargo rail/road interchange at Speed - will support the sustainable flow of cargo from road to rail and will reduce the congestion problems on the roads within Europe. The system will reduce the costs for road/rail intermodalism and will increase the speed of the operation at combined terminals. It will halve the economic break-even distance for intermodal freight movements. The reduction of costs of the complete system in comparison to common techniques will be at least to 30 %. Outcome of the project are two prototypes. A CargoSpeed rail-wagon and a transfer mechanism. A specific well floor for the wagon and a POP-UP lifting and turning mechanism will be constructed and demonstrated. In order to achieve a reliable and cost efficient system a simulation and animation of the terminal will be prepared and comprehensive dissemination and exploitation measurements will be carried out. The marketability will be proved.