RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Collective Dynamics of Sleep'.

assistant: **Objectives**

Sleep is a biological imperative for all animals: insufficient sleep can have detrimental effects on individuals’ health, cognition, social functioning and overall fitness. Even among gregarious species, sleep has largely been studied in lone individuals in laboratory settings, divorced from relevant socio-ecological context, limiting our ability to understand how social environments shape, and are shaped by, the sleep patterns of their members. My goal is to bring the study of sleep into the collective context, understand how social processes structure the sleep patterns of individuals, groups and populations, and test how gregarious animals navigate the opportunities and constraints imposed by sleeping as part of a group. To do this, I will integrate cutting-edge technologies with traditional field-observation methods to measure and model the collective dynamics of sleep among wild baboons. To continuously monitor movement, position, and sleep of baboons at the individual, group, and population levels, I will use GPS and accelerometry tracking of members of 30 troops of wild baboons. This will be combined with 3-D laser scanning of the physical sleep environment, overnight thermal videography, sleep-disruption field experiments, focal sampling of social behaviors, and advanced computational modeling to shed light on how differentiated and multi-faceted social relationships shape individual and collective sleep decisions, and how these decisions, in turn, shape the overall social dynamics of groups. This ground-breaking project will be the first to measure the collective sleep behavior of animal groups in a socially and ecologically relevant context. As such, it has the potential to shed wholly new light on social and ecological trade-offs that gregarious species – lik
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enabling malaria rhomboid proteases as drug targets: usage of molecular cookie cutters to shape novel activity assays and inhibitors.' (RHOMBOSMALPS) targeting Horizon 2020.

assistant: **Abstract**

Rhomboid proteases from P. falciparum, the causative agent of malaria, play a role in invasion of human red blood cells. The exact role of the individual members is challenging to track, because of difficulties in genetic manipulation of the P.falciparum and the inviability of some loss-of-function mutants. Hence, a chemical strategy is an attractive alternative. Unfortunately, the study of these eukaryotic rhomboids (PfROMs) has rendered impractical to date.The bottleneck is that the current purification techniques use detergents that eliminate the physiological membrane, yielding low enzyme stability and activity. In its turn, this rules out the use of activity assays and chemical probes to study their function. Encapsulating these proteins in their lipid environment will address these shortcomings. I will develop a detergent free purification method, based on a styrene maleic acid (SMA) polymer that functions as a “molecular cookie cutter”, creating SMA-lipid-protein nanodiscs, which retain their biological properties upon purification.Using this “molecular cookie cutter” to create lipid nanodiscs, I will isolate PfROMs and develop activity assays in order to identify and optimize novel inhibitors. The most potent and selective candidates will be evaluated in a malaria invasion model to verify the druggability of malaria rhomboids. Furthermore, these novel compounds may serve as leads for a new generation of therapeutic agents.The straightforward expansion of our approach to other intramembrane proteases may be the game-changer for drug discovery and future therapeutics directed against rhomboids from other species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cell Membrane Training to Advance Industrial Processes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

All organisms, from bacteria to humans are made of cells surrounded by membranes, which define them, separating them from their environment. Membranes precisely control what enters and leaves cells and how cells interact with each other and molecules in their environment. All these processes are fundamental to life; by harnessing and understanding them, we have the potential to influence human and animal health and disease, and generate improved microorganisms for biotechnological applications in the food, chemical and drug sectors. The membrane has traditionally proven relatively intractable to study, mainly due to its hydrophobic nature. However, recent technological and methodological advances, with key inputs by Aston University, have enabled this field to progress rapidly. There is now an urgent need for increased research training in this area. There is established and emerging evidence for the involvement of the membrane in a wide variety of industrially-relevant processes, encompassed by MemTrain’s three core themes of medicines discovery, biotechnology and underpinning technology development.  MemTrain is a five-year multidisciplinary, intersectoral PhD training programme for 12 PhD researchers. This programme will train the next generation of researchers who are primed to work on developing a new understanding of how to harness the full potential of cell membranes by working the interface of industrial and academic science. To work across these traditional boundaries, researchers will require a diverse skillset enabling them not only to undertake fundamental research but to apply this knowledge to current real-world problems underpinned by excellent communication and transferable skills. Innovative, collaborative training programmes within MemTrain will equip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Savage Warfare: A Cultural History of British and American Colonial Campaigns 1885-1914' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

This innovative project will provide a comparative cultural history of British and American colonial campaigns in Africa, South Asia and South East Asia, between 1885 and 1914. The project will provide a comprehensive study of what was known as ‘savage warfare’ that goes beyond the conventional military histories by examining the cultural assumptions and colonial knowledge that underwrote military practice. The project aims at making a substantial contribution beyond academia, and the historical exploration of colonial warfare cuts to the very heart of contemporary debates on the ‘war on terror’ and the continuing legacies of imperialism. The Experienced Researcher will expand his area of expertise on British imperial history to include American imperial and military history, as well as undertaking extensive archival research in Britain, the United States, India and the Philippines. The ER will spend 24 months during the outgoing phase at the History Department at George Washington University to receive training and gain new knowledge within the area of American imperial history. Following this, during the 12 months of the return phase, he will be hosted at Queen Mary, University of London, to transfer back the acquired knowledge and further consolidate his knowledge in the field. The deliverables of the project consist of two articles in per-reviewed journals and the completion of one book manuscript. The ER will furthermore organize two workshops in the United States and one major international conference at QMUL upon his re-integration into the ERA. The undertaking of this multidisciplinary project, that ties together European and American imperial history in a highly original manner, will significantly enhance the career opportunities of the ER and allow him to esta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing a Bayesian technique to evaluate the validity of economic models: two applications to the Euro Area' (BMC-SVAR) under Horizon 2020.

assistant: **Objectives**

The 2007 financial crisis and the 2009 European sovereign debt crisis highlighted how difficult it is to build models that capture the dynamics of the economic system. The project develops a model evaluation technique that allows a researcher to assess how much the economic models of interest to a researcher are supported by the data. The innovative technique set out in the project is developed in order to assist policy-makers address a wide variety of research questions, and to help them achieve their goals – for example, predicting the impact of interest rate changes on a country’s economy. Two applications to monetary policy by the European Central Bank are developed. The first application studies whether the data support a class of economic models used to assess monetary policy. The second application studies how successful monetary policy has been in counteracting deflationary pressures in the Euro Area. The fellowship will help me to pursue a career that applies an academic focus to policy-oriented research questions. Queen Mary is the ideal place to achieve this goal, because it is one of the best universities in the field of Applied Econometrics.  Having already developed an academic approach to research during my PhD in Economics and having recently started working on policy questions as a postdoctoral fellow, I now aim to combine these two experiences. The fellowship will help me to gain the skills in Applied Econometrics that I need for the successful implementation of the project, and to begin a career that focuses on the application of Applied Econometrics to policy questions. I will achieve this goal by working with my supervisor Professor Haroon Mumtaz, who has developed significant knowledge at the intersection of academic and policy research through his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Science Uncovered' (2014-2020).

assistant: **Concept**

NHM has successfully delivered 11 events at 6 consecutive European Researchers’ Nights that have attracted increasing public participation and proactive engagement. SCIENCE UNCOVERED aims to build on this experience to deliver at least 10 captivating events in 5 locations across the UK in 2016 and 2017.  Central objectives of SCIENCE UNCOVERED are to:[1] Actively breakdown existing public stereotypes of researchers[2] Create greater public awareness of the role of researchers and the value of science[3] Inspire the next generation of young researchers and demonstrate the varied roles and opportunities that are open to them for careers within science.An enhanced awareness campaign will make 34 million people aware of the ERN over two years. Awareness raising and a compelling array of activities will engage 20,500 participants directly.SCIENCE UNCOVERED aims to deliver deep public engagement with research as well as a greater dialogue between researchers and the wider public to further increase awareness of science and how future science benefits both European and global society. NHM strives to increase the public understanding of and engagement with science using extensive programme of high quality, innovative activities including media, capitalising on past experience and mobilising our network of providers in public engagement and research communities. NHM will be working with subcontractors to realise activities in 5 UK locations: London, Tring, Manchester, Newcastle and Belfast. The regional activities present an exceptional opportunity to reach “under-served” audiences including thousands of young people with limited opportunities to engage with research.SCIENCE UNCOVERED will deliver a high researcher-to-participant ratio of ca. 1:40 at all events as impact assessm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Strategy for sustainable irrigated agriculture in CAS with minimum investment in drainage - Tashkent workshop'.

assistant: **Objectives**

The objective is to prepare papers for, and to stage, a workshop in Tashkent that will enable key researchers, senior officials and expert practitioners, interested in the widespread water logging and land salinity problems of the Amuser Daryl regions of the CAS, at consider the results of present and completed technical work, and tic discuss what future basic elements should be taken into a logical strategy for the region. The challenge is to identify a realistic, economic construction/operation programme for land drainage. These future elements include identification of priority research needs, but also regional development needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Transcriptional footprints of cancer dependency shock as a computational tool for early anti-cancer drug discovery'.

assistant: **Concept**

The oncogenic shock model has been introduced to describe the interplay between pro-survival and pro-apoptotic signals that follow an oncogene's inactivation and lead to cancer cell death.In my recent work, I demonstrated that identifying novel cancer dependencies through systematic computational analyses of CRISPR functional genetic screens and multi-omic data is an excellent means to discover and prioritise new anti-cancer therapeutic targets. Here, I extend the oncogenic shock concept to any cancer dependency gene. I call cancer dependency shock (DepSHOCK) the signal dynamics interplay that follows the ablation of any gene essential for cancer cell survival, i.e., cancer dependency gene. Any DepSHOCK triggers the sudden inactivation of pro-survival pathways and activates death- inducing signals, with both events impacting down-streaming transcription factors, leaving a measurable gene expression footprint. My hypothesis is that each DepSHOCK footprint can be deconvoluted to infer transcriptional markers of signals that emanate from a dependency gene and drive cancer cell survival through the constitutive activity of specific biological pathways. Here I propose to investigate this hypothesis across tissues, canonical oncogenic addictions, and novel candidate cancer therapeutic targets. To this aim, I plan to establish an experimental/computational platform for the generation and the analysis of unprecedented transcriptional datasets obtained at single-cell resolution upon genetic perturbation of a rationally selected panel of cancer cell lines and therapeutically relevant dependency genes. My overarching goal will be to study the information content of the DepSHOCK footprints and their potential use as computational tools in early anti-cancer drug discovery through ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dopaminergic midbrain modulations by (adaptive) neurofeedback', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Value-based decision-making is crucial for human behavior and learning, pervades our daily life and goes astray in psychiatric disorders such as schizophrenia and depression. The neural activity of brain regions producing and being influenced by the neurotransmitter dopamine has been associated with value-based decision-making processes. By extension, one would expect dopamine systems, mainly midbrain regions and their striatal projections, to play a role in such decisions, such as whether a specific reward is worth enduring some punishment. It is a matter of debate, but of surprisingly little empirical investigation, whether the rewarding and punishing aspects of value differentially or similarly depend on the dopamine system. The project DOPANF aims to clarify this issue by investigating dynamic changes of dopamine-related neural activity. DOPANF develops two new paradigms to shed light on this important, yet neglected topic for public health and subjective well-being. Specifically, DOPANF uses recent neuroscientific and technological developments: real-time imaging for immediate analysis of neural activity in the midbrain and multivariate pattern analysis for algorithmic capture of related activity spatially distributed throughout the brain. By observing their own brain activity as neurofeedback in real time, participants will learn to volitionally up- and downregulate activity in the dopamine system. We will then measure the behavioral consequences of this regulation with regard to how much effort participants are willing to exert to obtain a reward. Thus, DOPANF aims to achieve a more precise understanding of decision-making behavior and elucidate the exact role of the dopaminergic midbrain in value processing and its impact on effort discounting. The project is fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A holistic approach to understand Earth formation'.

assistant: **Objectives**

How did Earth form with the properties that made it the only inhabited planet of the Solar System? Answering this question is the Holy Grail of planetary science and is key for (i) placing the formation of Earth into the context of general planet formation (ii) unveiling the fundamental processes that led to the formation of a planet able to sustain life and (iii) assessing the likelihood that similar processes occurred in other, extrasolar systems. However, despite decades of research, it is still unknown how Earth formed. Although several competing models exist, the reason we do not yet have a consensus on how Earth formed is that all proposed models have only been tested against a limited number of constraints (and sometimes different constraints for different models) with no common intersection. HolyEarth will overcome these limitations by developing a holistic approach to understand Earth’s formation that is based on the largest set of observational constraints: orbits, masses, formation timescales, chemical and isotopic properties of terrestrial planets and meteorites, and the structure of the asteroid belt (the relict of planet formation). The overarching goal of this project is to identify a unique scenario which, for the first time, simultaneously satisfies all these constraints in a self-consistent way. This project will break the boundaries between Earth science and astronomy by placing the formation of Earth in the context of a cosmic evolution towards stars and planets. Its impact will reach other scientific domains, such as biology and exobiology, and resonate with the public’s keen interest in the question of our origins.


**Keywords:** Earth formation, meteorites, asteroids and planetesimals, protoplanetary disk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'WBG Pilot Line' (WBGPilotLine) under Horizon Europe.

assistant: **Objectives**

The present proposal aims to realise an integrated pilot line focused on the developments of the wide–bandgap (WBG) semiconductors technologies for power and radio frequency (RF) electronics. The project will be realised by strengthening the existing facilities located in Finland, Italy, Poland, France, Austria, Germany and Sweden, and involving Universities and Research centres of the seven above-mentioned States operating in the field of advanced semiconductors and related technologies. The WBG semiconductor pilot lines will address all the front–end critical issues related to the realisation of devices with power and RF performance much higher than those realised by the conventional silicon technology, will define a clear roadmap for the development of such advanced technologies, will investigate strategies to improve the structural and electrical properties of WBG (and Ultra–WBG) semiconductors, and will develop new MEMS devices based on WBG and Ultra-WBG devices.