RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Employment of Advanced Deep Learning and Human-Robot Interaction for Virtual Coaching' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main objective of this project (DR VCoach) will be the following: “Design and implement a robotic coach able to propose a proper exercise schedule based on human directives, monitor the exercise performed by the patient/elder and correct it in case of mistakes”. The output of the project will be a robotic coach to assist the elders during their daily physical training. The robot will be able to understand verbal commands from the user (e.g. what will be the training schedule of today? Today I feel tired, can we do a lighter training?), to define the sequence of exercises to be performed, to show the exercises to the user (with a verbal description and performing them by it-self), to monitor the user performing the exercises using RGB cameras, to eventually find some errors in the execution and to suggest a correction to the mistake.The whole system can be divided into four modules:- Speech module: This is the module in charge of the vocal interaction between the robot and the elders. - Exercise scheduler: The role of this module is to break the selected exercise into atomic actions, and send these actions to the Error detector and Action recognition and prediction modules. - Error detector: The Error detector module analyses the results coming from the Action recognition and prediction module based on the required actions received by the Exercise scheduler. After evaluating the performed action, the module sends an evaluation report to the speech module in order to inform the elder. - Action recognition and prediction: This module has the dual task of recognising the action performed by the elder using the RGB videos coming from its embedded camera, and predicting the future viso-proprioceptive stimuli based on the action that is being performed.The system will be i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Self-propelled Metal-Organic Framework nanocarriers as promising brain delivery platform' (NeuroMOF).

assistant: **Concept**

Neurodegenerative diseases severely affect patients’ health resulting in poor quality life and significant impact on global healthcare costs. The mayor challenge is the bypass of the blood-brain barrier (BBB), limiting the diffusion of therapeutic cargo to the central nervous system (CNS). Although emerging technologies based on nanomedicine (liposomes, polymers, etc.) are a promising approach to overcome the BBB, their clinical application is still limited by their lack of in vivo efficacy.In view of this scenario, a new class of nanoscaled porous Metal-Organic Frameworks (nanoMOFs) has attracted great attention in the biomedical domain. NanoMOFs present several advantages compared to classic nanocarriers: i) their chemical & structural versatility, allowing a suitable biocompatibility and the potential control of their in vivo fate, ii) exceptional loading of challenging ingredients (cosmetics, enzymes, drugs...) together with controlled release under physiological conditions; iii) green and scalable synthesis; iv) lack of in vitro & in vivo toxicity; v) interesting imaging properties. Latest biomedical advances have been focussed to tackle typical administration routes (e.g. oral, intravenous or cutaneous). However, the targeted delivery to the brain has not been under the spotlight within the scientific community.Thus, the aim of this proposal is to develop a biosafe and efficient nanoMOF platform for brain delivery. Two original strategies will be undertaken to overcome the BBB: targeting by external functionalization with BBB-specific ligands & enzyme immobilization (self-propelled nanomotors), facing up the challenge to control the orientation, stability, density and distribution (symmetric/asymmetric) of the surface agent. Apart from a full physicochemical chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identifying genetic and epigenetic changes underlying adaptation in the invasive species Drosophila suzukii' under Horizon Europe.

assistant: **Concept**

In the last few decades, problems related to the colonization of invasive species have become increasingly important at a global scale. Biological invasions are not only a threat to the environment but also have an important impact in economy. Thus, in order to manage and control invasive species, it is of crucial importance to understand the ecological and evolutionary processes that underlie successful invasive processes. In this project, I propose to investigate the genetic and epigenetic changes underlying adaptation in the destructive crop pest Drosophila suzukii. D. suzukii uses a sclerotized ovipositor to pierce the skin of unripe fruits causing dramatic losses to the fruit industry. It has spread from South East Asia to Europe and North America in only ten years, evidencing its invasive success.In the proposed work, I will first validate experimentally the function of candidate genomic regions related with the invasive success of D. suzukii using the state-of-the-art CRISPR/Cas technology. As such I will expand the knowledge of the genetic basis of the invasion process of this species. Besides, technical improvements of the use of CRISPR/Cas can be of future application in programs dedication to the biological prevention of this pest. Second, D. suzukii, as an invasive species, has to face with different oxidative agents when colonizing new environments such as the use of different herbicides or changes in UV exposure. In this work, I will identify for the first time the transgenerational epigenetic modifications induced after oxidative stress in native and invasive natural populations. I will also study whether those epigenetic modifications have any molecular or fitness effects and their possible association with invasive success. Overall, I expect these resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hybrid Access Reconfigurable Multi-wavelength Optical Networks for IP-based Communication Services' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

A common dynamically reconfigurable fibre infrastructure is proposed, deploying flexible wavelength routing integrated with flexible time slot allocation in a new Medium Access Control protocol. This infrastructure feeds various last-mile access networks, and provides capacity on demand while accounting for Quality of Service requirements of user traffic. An adaptive resource manager supports the MAC protocol, and aligns traffic flows with core and last-mile network capabilities. Both a wireless HIPERLAN2 and a twisted-pair VDSL user access network enabling QoS-differentiated IP traffic will be set up. Novel optical modules will be developed, such as a fast flexible wavelength router. The results of architecture studies and techno-economic analyses will be fed into consensus building activities and standardisation bodies. After being validated in laboratory trials, the system will be operated in a field trial with real users and IP-based QoS-sensitive services.Objectives:The main objective is:to stimulate the convergence of access networks supported by;- to devise a dynamically reconfigurable fibre-based feeder network infrastructure, supporting a wide variety of last-mile customer access networks;- to devise a packet-based WDMA/TDMA MAC protocol, offering capacity-on-demand;- to devise control plane protocols for a range of QoS classes for IP-based services;- to assess the techno-economical aspects of the system concept and alternatives - developing evolution strategies leading to convergence of hybrid access networks;- to develop novel optical system modules supporting the WDMA/TDMA system concept;- to evaluate the key functionalities of the system in a laboratory testbed;- to demonstrate the viability of the system in a field trial involving real-life IP-based servic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High level Integrated SEnsor for NanoToxicity Screening'.

assistant: **Innovation**

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Implementation of early detection and early intervention service delivery in infants at risk for cerebral palsy to promote infants’ psychomotor development and maternal health' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite advances in the medical management of high-risk pregnancies and deliveries, cerebral palsy (CP) remains the most common physical disability in childhood in high and low-to-middle income (LMIC). In addition, caregivers of children with CP are at higher risk of psychiatric issues, further increasing health and socio-economic burden to the families. In spite of the scientific advancements in early detection and intervention (EI) in CP, there is a lack of implementation into clinical service delivery. The overarching aim of the BORNTOGETTHERE program is to exploit current evidence on early detection and efficacy of EI for infants at high risk of CP by implementing the International Clinical Practice Guideline in Europe (Italy, Denmark, Netherlands),  LMIC (Georgia, Sri Lanka) and hard to reach populations (Remote Queensland and Western Australia). It will provide a multifaceted knowledge translation approach focused on i) optimizing context-specific health programs for early detection of CP, thus reducing age at diagnosis and age at referral to EI; ii) optimizing early functional characterization of infants with CP, thereby fostering personalized EI and preventing secondary complications (i.e. hip dislocation) and iii) testing the implementation of integrated EI programs adapted to country-specific welfare systems. The protocol of service delivery will result from the adaptation of early detection and EI programs based on the proven, effective intervention strategies, and those that are included into ongoing research based on effectiveness shown with preliminary data. This framework will be validated in real life varying world conditions through a large implementation program and a multicentre parallel controlled trial. The main beneficiaries will include a wide ran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Technologies for Safe and Controlled Martian Entry' (SACOMAR).

assistant: **Innovation**

The main objective of the study is the experimental and numerical study of gas surface interaction phenomena in the high enthalpy flow field behind the bow shock in front of a model at Martian entry flow conditions. The improvement of physical modelling using experimental data and its implementation into the CFD codes is essential to understand and interpret the physical processes. At the end the project will allow to estimate the aerothermal loads on the vehicle more accurately. Main activities of the project are:-Definition of requirements on experiments, modelling and CFD codes using realistic Mars mission profiles-Experiments on the measurement of flow parameters in the free stream and behind the shock and stagnation point heat flux rate-Improvement of existing physical models with respect to the non-equilibrium effects, transport properties and gas surface interaction chemistry-Implementation of improved physical models into the CFD codes and simulation of experiments-Synthesis of the data and extrapolation to the flight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Si on SiC for the Harsh Environment of Space'.

assistant: **Innovation**

The SaSHa (Si on SiC for the Harsh Environment of Space) project will accelerate the development of an entirely new generation of power electronic semiconductor devices benefitting Space and several terrestrial applications. Proof of concept prototypes (up to TRL5) will be developed that incorporate a brand new Si on SiC substrate solution into state-of-the-art power electronic device architectures. The resulting power devices will be capable of working at voltage ratings from 50 to 600 V, in high radiation conditions and at temperatures up to 300°C, characteristics unavailable in the current power market, let alone for Space. By solving the so-called self-heating effect of state-of-the-art silicon-on-insulator electronics, this disruptive technology will offer: 1) significantly improved device efficiency with at least 50% less wasted power; 2) three times the power density; 3) a significant increase in the maximum operating temperature, by as much as 100°C and 4) a radiation tolerance to match the current state-of-the-art. These characteristics translate into a more efficient power system to boost on-board power and waste less heat. This reduces the burden on the cooling system saving mass and space on the spacecraft, and increasing mission length. Therefore, this is a technology enabling or benefitting several space technologies including high voltage solar arrays, electric propulsion, and many ancillary power conditioning applications. Furthermore, in the future, it will also find use in many terrestrial harsh environment applications including downhole drilling, aviation and automotive.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Functional tumour genomics using metabolomic profiling'.

assistant: **Objectives**

Metabolite profiling, as demonstrated by the host laboratory, has the power to discriminate single gene alterations and to identify metabolite biomarkers that potentially can function as surrogates for the genetic event. In addition they have shown that pattern recognition within NMR-derived metabolome profiles from gene deletion mutants can be used as a functional genomics tool to confirm the identity of modules or co-sets predicted by genome-scale metabolic models, demonstrating how metabolomic data can be used to understand the structure of metabolic networks, relating the metabolome to the genome. The aim of this project is to define the metabolic profiles associated with the expression of specific genes in tumour cells. This will allow us to define the metabolic network structure in tumour cells (and how it is related to expression of different oncogenes and tumour suppressor genes), and to identify metabolites that are correlated with common genetic changes in cancer cells. This should allow us to design new molecular imaging methods for detecting tumours and their response to treatment. Moreover, the proposed work will also allow us to understand the effects of specific drugs, by allowing us to monitor the modulation of the activity of specific drug targets and also by identifying off-target drug effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Development of multi-scale molecular models, force fields and computer software for biomolecular simulation'.

assistant: **Concept**

During the past decades the PI has helped shape the research field of computer simulation of biomolecular systems at the atomic level. He has carried out one of the first molecular dynamics (MD) simulations of proteins, and has since then contributed many different methodological improvements and developed one of the major atomic-level force fields for simulations of proteins, carbohydrates, nucleotides and lipids. Methodology and force field have been implemented in a set of programs called GROMOS (GROningen MOlecular Simulation package), which is currently used in hundreds of academic and industrial research groups from over 50 countries on all continents. It is proposed to develop a next generation of molecular models, force fields, multi-scaling simulation methodology and software for biomolecular simulations which is at least an order of magnitude more accurate in terms of energetics, and which is 1000 times more efficient through the use of coarse-grained molecular models than the currently available software and models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Development and testing of a combined anti-retroviral, immune, and gene therapy for treatment of hiv patients'.

assistant: **Objectives**

The treatment of HIV patients has been greatly improved by the development overheard. However, despite a strong reduction in the number of virus producing cellsHAART does not fully eradicate the virus, making sustained treatment necessary. In addition, immune function is only partly restored during HAART. Therefore, the focus has recently shifted to supplementing HAART with additional immune therapy. The aim of this project is to develop and test a new protocol for the treatment of HIV patients, based on a combination of anti-retroviral, immune and gene therapies. The main target of this therapy shall be to restore CD4 helper T-cell immune responses. These cells are central immune regulators that largely determine the type and strength of the immune response generated following antigen encounter and thus the efficiency with which a particular infection is controlled by the body.