RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A new manufacturing method, monitoring platform and material equipment to carry out a more efficient production of plastic bottles, reducing its waste.' to be submitted under Horizon 2020.

assistant: **Abstract**

The plastic Polyethylene Terephthalate (PET) is one of the most used non-biodegradable materials on the planet. In 2010,demand was 12,621,553 tonnes and it is forecast to grow to 23,452,287 tonnes by 2020. This continuous annual growthhighlights a devastating problem facing all of humanity. In addition to this increase in the consumption of plastic, and thedifficulties of plastic disposal, there is an incapability of plastic manufacturing companies to control the productionadequately. In fact, they endure the instability inherently caused by PET raw material variation, the resulting scrap rates, andthe low possibility to use recycled material.ACCUCOLOUR reduces these impacts with “PET Plastic Yield”, an advanced product composed of new materials and anew manufacturing process, equipped with constant monitoring. PET Yield enables plastic packaging manufacturers: ahigher efficiency in the entire manufacturing process; a 4% reduction in scrap rates, and an increased potential for use ofrecycled material between 50% (in food packaging) and 100%. Increasing the use of recycled PET and decreasing scraprates, ACCUCOLOUR will have a substantial impact on the health of the environment, especially on the marine ecosystemin Europe.Further, over 30 positions will be created at ACCUCOLOUR alone, not including indirect growth for customers.ACCUCOLOUR's role in the market will be very strong as it will be physically close to the main potential clients in order tofoster face-to-face relationships. During the Phase 1 feasibility study the project will focus on identifying and securing the keypartners required for commercialisation, establishing a sound business model and commercialization strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of GABAergic microcircuits with different embryonic origins in the orchestration of early cortical dynamics in the awake mouse pup' (GABACODEV).

assistant: **Concept**

Because of its function in brain wiring and in the generation of early correlated activity patterns, the maturation of GABAergic transmission plays a key role in enabling brain complexity in higher mammals. Indeed, disruption of GABAergic circuitry at several time points can contribute to the generation of developmental disorders such as schizophrenia, autism or epilepsy (Le Maguerise and Moyner, 2013). Both in the murine hippocampus and neocortex, GABAergic interneurons have been shown to participate in the emergence of a precise temporal sequence of distinct correlated neuronal activity patterns during early postnatal development (Crepel et al., 2007; Allene et al., 2008). In particular, GABAergic cells with an extended and divergent axonal connectivity (operational “hub” neurons) (Bonifazi et al., 2009; Picardo et al., 2011; Cossart, 2013) have been described to be capable of synchronizing single-handedly populations of cells in developing hippocampal slices (Bonifazi et al., 2009). This project builds up on a solid ground of unpublished in vitro data from the host lab indicating that a specific, but diverse functional subpopulation of GABA neurons could also operate as hub cells in the developing neocortex. Experimentally, it will benefit from recent technical developments from the host lab aiming at manipulating and visualizing the activity of single neurons in the awake mouse combining genetic and microscopy tools.  Indeed, if operational hub neurons have been described in vitro, it remains unknown how they integrate into functional networks in vivo, and more generally how GABAergic activity shapes early cortical network dynamicsThis proposal aims at translating from the in vitro to the in vivo situation a multidisciplinary approach to investigate the functional c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Unlocking data content of Organ-On-Chips', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The launch of a novel drug to the market is preceded by clinical testing and validation both on animal in vitro and in vivo models. Animal models used in drug development have known methodological drawbacks leading to the failure of drugs. Further, animal tests are associated with ethical issues. Moreover, a strong bias in in-human testing still overlooks major population groups e.g. children, women, different ethical groups. It is estimated that 197,000 deaths per year in the EU are caused by Adverse Drug Reactions (ADRs) and the total cost to society of ADRs is €79 billion. The emerging Organ-on-Chip (OOC) field, an alternative to animal test, brings great potential for safe testing and validation: An OOC-systems consists of a 3D-microstructured channel network embedded on a small plastic device that simulates the mechanics and physiological response of an entire organ or organs. Project UNLOOC will develop, optimize, and validate a multitude of ECS-based tools to build OOC-models to replace animal and in-human testing. UNLOOC aims to combine three important characteristics for routine use of OOC models, i.e platforms that combine ECS-based technologies with established biological material, capitalize on AI, parallelized test set-ups allowing efficient high-throughput demands, and standardized procedures enabling reliable results. UNLOOC will develop ECS-based hardware and software tools and validate them in five Use Cases (UCs) performed in 10 European countries. The applications developed and validated will be used by academia and pharma industry to drive drug development, create cosmetics without animal test, personalized medicine and gain new insights into disease. Given the large OOC market, these solutions have great economic value, on average it would result in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Visual Learning and Inference in Joint Scene Models'.

assistant: **Innovation**

One of the principal difficulties in processing, analyzing, and interpreting digital images is that many attributes of visual scenes relate in complex manners. Despite that, the vast majority of today's top-performing computer vision approaches estimate a particular attribute (e.g., motion, scene segmentation, restored image, object presence, etc.) in isolation; other pertinent attributes are either ignored or crudely pre-computed by ignoring any mutual relation. But since estimating a singular attribute of a visual scene from images is often highly ambiguous, there is substantial potential benefit in estimating several attributes jointly.The goal of this project is to develop the foundations of modeling, learning and inference in rich, joint representations of visual scenes that naturally encompass several of the pertinent scene attributes. Importantly, this goes beyond combining multiple cues, but rather aims at modeling and inferring multiple scene attributes jointly to take advantage of their interplay and their mutual reinforcement, ultimately working toward a full(er) understanding of visual scenes. While the basic idea of using joint representations of visual scenes has a long history, it has only rarely come to fruition. VISLIM aims to significantly push the current state of the art by developing a more general and versatile toolbox for joint scene modeling that addresses heterogeneous visual representations (discrete and continuous, dense and sparse) as well as a wide range of levels of abstractions (from the pixel level to high-level abstractions). This is expected to lead joint scene models beyond conceptual appeal to practical impact and top-level application performance. No other endeavor in computer vision has attempted to develop a similarly broad foundat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Direct Reprogramming for Predictive Nephrotoxicity Testing (DRiPNeT).' to be submitted under Horizon Europe.

assistant: **Abstract**

Acute tubular necrosis (ATN) is a major cause of nephrotoxicity-related drug attrition in clinical trials, yet current preclinical models rely on animal studies or immortalized renal cell lines, which lack human physiological relevance. To address this gap, we have developed a directly reprogrammed renal epithelial cell (iREC) platform, enabling a human-specific, scalable, and high-throughput nephrotoxicity screening assay.Our iREC-based system overcomes the limitations of primary, or iPSC-derived models by offering a rapid, reproducible, and physiologically relevant alternative model. Building on the advances of the ERC-Starting Grant project DiRECT, this project will validate the iREC-based platform by screening a curated panel of nephrotoxic and non-nephrotoxic compounds, assessing performance metrics, such as specificity, sensitivity, and Predictive value to benchmark against other model systems.This project aims to establish the technical and commercial feasibility of iREC-based nephrotoxicity testing, seeking more predictive human-based preclinical models. The outcome will provide a cost-effective, scalable alternative to animal testing renal safety screen. Ultimately, this project will help reduce late-stage drug failures, improve patient safety, advance personalized risk prediction, and accelerate the development of safer therapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FUNctionalized POLYmer electrolytes for energy STORagE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Besides the need for large-scale implementation of renewable energy sources, there is an equivalent need for new energy storage solutions. This is not least true for the transport sector, where electric vehicles are expanding rapidly. The rich flora of battery chemistries – today crowned by the Li-ion battery – is likewise expected to expand in upcoming years. Novel types of batteries, “post-lithium ion”, will challenge the Li-ion chemistries by advantages in cost, sustainability, elemental abundance or energy density. This requires significant improvements of the materials, not least regarding the electrolyte. The conventional liquid battery electrolytes pose a problem already for the mature Li-ion chemistries due to safety and cost, but are particularly destructive for future battery types such as Li-metal, organic electrodes, Li-S, Li-O2, Na- or Mg-batteries, where rapid degradation and loss of material are associated with incompatibilities with the electrolytes. In this context, solid state polymer electrolytes (SPEs) could provide a considerable improvement.The field of solid polymer electrolytes (SPEs) is dominated by polyethers, particularly poly(ethylene oxide) (PEO). This application regards moving out of the established PEO-paradigm and exploring alternative polymer hosts for SPEs, primarily polycarbonates and polyesters. These ‘alternative’ polymers are comparatively easy to work with synthetically, and their possible functionalization is straightforward. The work aims at exploring functionalized alternative polymer host for mechanically robust block-copolymer systems, for alternative cation chemistries (Na, Mg, etc.), for extremely high and low electrochemical potentials, and for unstable and easily dissolved electrode materials (sulfur, organic). Moreover,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of technologies for advanced treatment of metal alloy surfaces for special applications in the aerospace and bio-medical sectors' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project - called SURFACES - concerns the transfer of knowledge between an industrial engineering company and three Universities in three different member states of the EU. The knowledge transfer will occur through the secondment of 12 researchers between the partners to implement a number of research projects concerned with innovative coatings on advanced alloys. The products developed will have applications in areas such as the gas turbine industry, and also bone implant materials in the medical sector.The project partners are:(1) SIFCO Turbine is an engineering company based in Cork, Ireland. SIFCO manufactures and repairs components of aero-engines and industrial gas turbines.(2) Cranfield University is a post-graduate research University based in the United Kingdom. Cranfield's School of Industrial and Manufacturing Science has an international reputation for research in gas turbine technologies.(3) Universite La Rochelle (France). ULR's Laboratoire d'Etudes des Materiaux en Milieu Aggressives (LEMMA) has advanced expertise in chemical and electrochemical removal of coatings from metal alloys.(4) The Trinity Centre for Bioengineering (TCBE) at Trinity College Dublin. TCBE has advanced expertise in the evaluation of graft materials, including the osseo-integration of bone implants.The proposed research has strong inter-disciplinary dimensions and will involve interaction between engineering, materials and bio-medical technologies. Successful implementation of these projects will enhance SIFCO's competitive position in the global market for turbine component repair. The work will also enhance the research capability and the research reputations of the three University partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preserving Wooden Heritage. Methods for monitoring wooden structures: 3D laser scanner survey and application of BIM systems on point cloud models' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Wooden Heritage has been recognized today as an object of growing interest in scientific research even on international scale, not only from the architectural point of view but also from theoretical approaches. Over the times many technological systems concerning timber have evolved, refined and defined in the use of mixed solutions. Wooden Architecture represents one of the oldest building systems adopted by the majority of people who developed construction techniques respecting the local traditions. Today this vast and unique wooden heritage needs urgently survey and cataloguing. Fires and abandonment are the main factors jeopardizing the preservation of this architecture; every year too many wooden buildings still disappear because of this negligence. This important challenge has the purpose to obtain new technical methods, procedures and protocols that don’t exist yet, fundamental for technicians and operators. The research project wants to address a new scientific approach on wooden buildings. This is aimed for practical interventions for with respect to the scientific and epistemic foundations, by improving 3D laser scanner survey and photo-modelling activities through post production phases with parameterization of the point cloud to create 3D digital models queried and enriched by informative content and increase BIM (Building Information Modeling) knowledge. The main and most important contribution of this project is the accomplishment of scientific, technical and operational systems and tools for the documentation of wooden structures. During the process of analysis different experts belonging from the best host companies chosen, will guide, check and develop jointly with the applicant all the methods, procedures and theoretical background for achieving the be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting ER Import And Activation Of Viral Glycoproteins: Towards Broad-Spectrum Antivirals' (VIGILANT), addressing dissemination and exploitation.

assistant: **Impact**

The VIGILANT consortium is dedicated to tackling the global threat posed by emerging viruses, exemplified by the COVID-19 pandemic and the Ebola epidemic in Western Africa. These events have emphasized the profound impact of such viruses on human health and economic stability. Moreover, anthropogenic factors, notably climate change, will result in an increase in the frequency of outbreaks caused by these viruses in the future. To address this vulnerability, the VIGILANT consortium pursues the development of antivirals with broad-spectrum activity. Pioneering research conducted by the consortium has identified the inhibition of the Sec61 channel and virus-activating host proteases as a promising strategy. The consortium's efforts are centered on addressing priority diseases defined by the World Health Organization due to their epidemic potential and the lack of countermeasures. Thus, the VIGILANT consortium aims to provide new insights into the protease dependence of emerging viruses, including Ebola virus, Marburg virus, Nipah virus, Zika virus, and Chikungunya virus. Furthermore, VIGILANT will develop inhibitors of the virus-activating proteases furin and cathepsin B/L that are safe and exert broad and potent antiviral activity in cell culture and animal models and are thus ready for clinical evaluation. Furthermore, VIGILANT will devise inhibitors targeting Sec61 and will determine breadth of antiviral activity and potential resistance mechanisms. To achieve these ambitious goals, VIGILANT has assembled an array of partners with unique resources and expertise. These partners have demonstrated success in inhibitor development, protease profiling, protein structure determination, and analysis of antivirals. By leveraging their collective capabilities, the VIGILANT conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated tool for simulation of textile composites' (ITOOL) targeting Sixth Framework.

assistant: **Abstract**

The overall aim of ITOOL is to increase the usage of textile preforming for composites in Aeronautics applications. It is well-known from related projects that preforming offers a potential cost saving of 20-30% in materials and processing compared with p repreg technology. But a still missing prerequisite for taking advantage of this potential are adequate design and analysis methods and especially validated simulation tools. The technical approach of the project covers this aspect by development of an int egrated solution, simulating the manufacturing and processing chain as well as the loading stage to get reliable results also for 3d fibre architectures. Focus is laid on braiding, weaving and stitching technologies including also Non Crimp Fabrics. The r esulting types of preforms will be analysed on different approximation levels (micro / meso / macro modelling) to take inhomogeneous fibre distribution and waviness into account. To fulfil the objectives within a limited time (and cost) scale, the linking and integration of different stand-alone solutions in the tool chain is proposed thus creating an open flexible interface for fluent data exchange and communication. The alternative to develop new multi purpose software would be prohibitively costly. The main value is therefore gained for the user of textile composites. ITOOL can set up a standard for testing, modelling and simulation with minimized interference and without data loss and by this reply to the market demands. Further impact of the enhanced simulation capabilities will be a distinct reduction of at least 20% in necessary testing effort as well as a lead time reduction of more than 15%. The proof of this concept will be performed for different application examples in Aeronautics and summarize d in guid