RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Knowledge Management for Help Desk Operators' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The ASSIST project focuses on the needs of large organisations operating help desks for providing their operators, especially remote workers, with knowledge management facilities. The benefits sought with those facilities concern:Effectiveness and efficiency of work, Corporate learning, Flexibility and scalability of operations.The project combines innovative technologies such as XML-based knowledge representation, advanced user interface and integration of knowledge management with operations performance measurement.The ASSIST solution will be validated through pilot integration with 2 Help Desks in the sectors of Telecommunication and Postal services. Objectives:The ASSIST project focuses on the needs of large organisations operating help desks for providing their operators, especially remote workers, with knowledge management facilities. The benefits sought with those facilities concern:Effectiveness and efficiency of work, i.e. to support help desk operators with the relevant corporate knowledge and expertiseCorporate learning, i.e. to get feed-back from the help desk operators on customers problems in order to improve both operations and support material Flexibility and scalability of operations, i.e. to involve remote workers (be they working solely remotely or combining office and home work)Work description:Levering upon innovative technologies such as XML-based knowledge representation, advanced user interface and integration of knowledge management with operations performance measurement, the ASSIST project proposes a solution that links operators - be they local or remote - to Help Desk services and enables:Wrapping all Help Desk resources in an intuitive front end; resources are customer care information systems, interpersonal communication facilities, knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Positional cloning of the pulmonary adenoma progression 1 (papg1) gene'.

assistant: **Concept**

The Papg1 locus, on mouse chr. 4, affects lung tumour progression. We propose the positional cloning of the Papg1 gene, by shortening the mapping region using appropriate crosses, and by the analysis of candidate genes through a transcript map of this region.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'ELENA - Creating a Smart Space for Learning'.

assistant: **Concept**

The objective of the ELENA project is to demonstrate the feasibility of smart spaces for learning. Smart learning spaces are defined as educational service mediators, which allow the consumption of heterogeneous learning services via assessment tools, learning management systems, educational (meta) repositories and live delivery systems such as video conferencing systems or iTV. Central design element of the ELENA smart learning space is a dynamic learner profile, which includes learning history, learner ecific information and learning goals. Interconnecting learning services in a smart learning space leads to an empowerment of learners since they become capable of choosing among a variety of knowledge sources in order to achieve their personal learning ols. ELENA prepares the grounds for the rise of educational service markets and new service value chains, which will allow institutions to treat the performance of educational services as a make-or-buy decision.OBJECTIVES- To analyse existing standards for modelling learning-relevant data beyond learning objects and to provide recommendations for their further development;- To develop schemas describing educational services such as educational activities, learning delivery, teaching assessment and learner assessment;- To design and implement a smart space for learning that integrates heterogeneous services such as assessment services, content brokerage, learning management and human resources management;- To test the applicability of smart spaces to the field of education and training from a business and organizational perspective and draw conclusions for the design of intelligent environments in this field;- Develop best practice guidelines for deploying smart learnig spaces from an organizational, technological and ped
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Food safety in europe - the next step'.

assistant: **Concept**

The proposal aims to maximise use aft valuable information generated from the Commission-supported conference Food safety in Europe - challenges and Opportunities", being held in London in October 2010. The objectives are1) To provide free access for all to full proceedings in both paper and electronic format and gather feedback2) To obtain feedback on food safety developments from key sectors to assist policy makers on National and European level and3) To create a format for optimum information dissemination for each sector identified. These objectives will be achieved through production and distribution of summarised proceedings to the target sectors education, media, research, industry, policy makers and consumers and the use of working groups to obtain full feedback on a Europe-wide scale."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The ProM platform: New ways to drug the undruggable'.

assistant: **Concept**

Existing pharmaceutical methods can only target 15% of all proteins in the human proteome. Given this limitation, pharmaceutical companies are running out of options to develop effective drugs to tackle hard-to-treat diseases. To have a better chance of fighting these diseases, further targets of the remaining, so far undruggable 85% of our proteome need to be unlocked. PROSION developed a disruptive platform of chemical building blocks called ProMs. The ProM-platform addresses a specific class of yet undruggable proteins linked to hard-to-treat-diseases. ProMs can be combined into small molecule drugs to target proteins that play a key-role in pathologies such as cancer, Alzheimer’s, cardiovascular diseases and immune mediated disorders.The platform’s potential is currently being validated: in its first project, PROSION addresses a yet undruggable target to potentially provide new therapies for pancreatic and breast cancer and fight drug-resistance effects within cancer therapies.


**Keywords:** ProMs,undruggable diseases,Cancer,Drug discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation Relay Centre Latvia - promoter of transnational technology transfer within EU IRC network' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The general objective of LATIRC project is to contribute to the integration of Latvia in Europe by providing high quality and cost-effective services that promote transnational technology transfer and assure certain economic benefits for the client compani es. In the period of joining EU, it is very important for Latvia to be a part of IRC Network, to benefit from it and to contribute to it. IRC Network has approved its efficiency in the transnational technology transfer and improvement of innovation perform ance. The project LATIRC is introducing the IRC Latvia, who will implement the Network activities in Latvia. IRC Latvia will provide qualitative and cost-effective services that promote trans-national technology co-operation and commercialization of resea rch and innovation. The IRC Latvia services will be pertinent to regional needs and provided in synergy with national and regional support structures, responsible for innovation and industry development. IRC Latvia will conform the innovation promotion and technology transfer activities with national governmental and institutional organisations. IRC Latvia will stimulate the integration between research and industry and promotion of innovation-friendly policy and environment. The IRC Latvia activities wil l concentrate on SMEs as their principal target group, although also other organizations will be included in the scope of activities, like universities, research centres, larger companies, professional and trade associations, enterprise support centres and development agencies. IRC Latvia activities will cover the whole territory of Latvia. Experienced and professional IRC Latvia team will do its best to achieve the project goals. The project will be executed by the Latvian Technological Centre (LTC). LTC has a 4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Managing enterprise-scale multimedia using an open framework for information re-use'.

assistant: **Objectives**

The Memoir project will demonstrate the applicability and integration of advanced distributed multimedia systems to help manage diverse technical information sources in two pan-European R&D-based corporations. Large companies which are heavily dependent on the effectiveness of their R&D function face a particularly acute problem in providing effective means for their research, technical support and sales staff to access and share common technical information. The results of Memoir will help answer such problems.The demonstration systems developed during the project will show that the same source information can be productively accessed via a single multimedia information infrastructure by users with very different information requirements. The use of such a multimedia information infrastructure can substantially increase the productivity of researchers and other technical information users. The key information technologies to be integrated into a multimedia system solution for large distributed R&D corporations include: --document management systems.- hypermedia link services. - autonomous software agents. The Memoir project consortium brings together organisations from four EU member states to tackle the problem. All participants are leaders in their fields, and all have complementary business and technical objectives. Both Unichema International, a leading oleochemicals company, and Glaxo Wellcome R&D have identified the application of advanced IT to managing technical information as a key strategic technical capability, and will provide a strong corporate end-user drive for the project. Technological development will be provided by Ibex Computing, producers of the Dawn document management system, Multicosm, hypermedia link service technology developers, and the Unive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Harnessing the electrochemical power of oxygen'.

assistant: **Innovation**

The recent discovery of anionic redox chemistry has unveiled a new transformational paradigm for designing sustainable rechargeable batteries with superior energy density. Li-rich layered oxide (LLO) cathodes exhibiting oxygen redox activity can deliver exceptional capacities (> 40% higher than state-of-the-art NMC811), due to the cumulative cationic and anionic redox processes. However, the LLOs suffer from poor energy efficiency, reduced power density and voltage decay, caused by progressive irreversible migration and trapping of transition metals in intermediate sites in the structure during operation. In this context, the aim of the project is to target new LLO polymorphs with improved stability and performance through crystal engineering of the oxygen stacking sequence and tuning of local cation-cation interactions. First, I will leverage my expertise in in situ X-ray/neutron diffraction and total scattering methods to study the evolution of the atomic structure (average and local) during synthesis of selected LLO compositions. This will (1) dramatically reduce the time needed to cover parameter space, (2) facilitate identification of the optimal reaction conditions for specific LLO polymorphs, and (3) provide fundamental mechanistic insight. Secondly, this information will be used to target LLOs with different structural configurations and systematically examine the relationship between their electrochemical performance and structural evolution during operation. Thirdly, I will investigate the charge compensation mechanisms (cationic and anionic) of the materials, which will be related to the structural changes as well as electrochemical data to yield a complete mechanistic picture of the synthesis-structure-property relationship in the system. This fundamental gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The development of aggressive and depressive problems during adolescence' to be submitted under Seventh Framework.

assistant: **Abstract**

The present study proposes to investigate the development of aggressive and depressive problems during adolescence using developmental psychopathology as a conceptual framework. Developmental psychopathology is concerned with individual differences in the predictors, course, and outcomes of adaptive and maladaptive developmental processes. Three objectives are proposed: (1) to identify groups of adolescents exhibiting differential levels of distinct or combined aggressive and depressive problems across time, (2) to investigate the relationship of risk and protective factors to aggressive and depressive problems, and (3) to identify differential outcomes of aggressive and depressive problems. These objectives will be tested in a sample of 700 European adolescents. To investigate co-occurrence during adolescence a longitudinal model will be employed across four consecutive years (grades 7 to 10). Data will be analyzed using the longitudinal person-oriented methodology General Growth Mixture Modeling (GGMM). This is the first study to investigate the co-occurrence between aggressive and depressive problems using GGMM, and the study is expected to provide evidence of how and why aggressive and depressive problems, two symptoms from different diagnostic classes representing separate forms of psychopathology, co-occur in children. Furthermore, findings of the current study can provide evidence that may lead to effective interventions and treatments. Moreover, using the template provided by the proposed study on how to investigate co-occurrence, future studies conducted in the EU can inform the world about co-occurring disorders and therefore enhancing EU scientific excellence. The Marie Curie International Reintegration Grant will enhance the career development of the researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanism of homology search during homologous recombination' under Seventh Framework.

assistant: **Concept**

Homologous recombination is a mechanism by which DNA double-strand breaks are faithfully repaired using the sequence information present on an intact duplex DNA. The efficiency of this mechanism is crucial for cell survival, and its accuracy is of prime importance for genomic stability. Although being the signature reaction of homologous recombination, the search for homology performed by the broken molecule coated with the Rad51 recombinase (called the “nucleoprotein filament”) is poorly understood: how a single entity is able to scan the megabases of the genome to rapidly find its unique homologous target remains a mystery. My post-doctoral project aims at tackling this long-standing ""needle-in-a-haystack"" problem. For this, I introduce new concepts and approaches to elucidate how this potent search takes place in a massive excess of competitor DNA.First, we hypothesize that several sections of the nucleoprotein filament are able to sample different duplex targets at the same time. This multiplexed search process by the nucleoprotein filament will be studied in vitro and in vivo. In particular, I will develop a technique derived from chromosome conformation capture to isolate and quantify “multiple invasions” performed by the nucleoprotein filament in vivo.Second, I intend to identify the functional substructure of the nucleoprotein filament, which is not a simple homogeneous assembly of Rad51 along the single-stranded DNA. Instead, it embeds other proteins, like the translocase Rad54 and the Rad51 paralogs, which exert a positive role on homology search through still unknown mechanisms. In particular, I will study how these proteins participate in the rapid rejection of pairing to heterologous molecules.Third, I will study the processing of the “multiple invasions”
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A New Measure of Socioeconomic Inequalities for International Comparison'.

assistant: **Objectives**

The overall objective of the INCASI2 project is to establish a global cross-sectoral network of experts working on a joint research programme aimed at building a new analytical model of socioeconomic inequalities in order to: a) To produce effective advances in the understanding of the complex phenomena of socioeconomic inequalities creating a fresh analytical framework at a comparative and interdisciplinary level in a context of societies in ""permanent crisis"".b) To construct an innovative multidimensional measure (DYSIC: Dynamics of Socioeconomic Inequality in Comparison) adapted to the new realities shaped in this context that is global, more comprehensive and realistic in the comparative analysis of inequalities between Europe and Latin America & the Caribbean, and to monitor the situation and evolution of inequalities. We consider 3 DYSIC variants: 1) including 3 main dimensions as a base (education, occupation and income), 2) adding gender dimension and 3) adding dynamic trends.c) To create the INCASI Living Lab to elaborate diagnoses, contribute to informed decision-making and the design of public policies. It is designed to enhance the innovation process by embracing three core principles: fostering a collaborative open innovation strategy, utilizing a methodology centred on promoting the quality of life for individuals, and creating an environment for interdisciplinary thinking and action that enables the participation of diverse socioeconomic, political, and scientific agents.These objectives will be achieved with a collaborative work of an interdisciplinary, intersectoral and international network for Comparative Analysis of Socioeconomic Inequalities (INCASI) with 29 organizations: 14 EU universities from 6 countries, 11 universities and 4 non-academic org