RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gut Influences on Brain and Mind' (GUT-FEEL) targeting Horizon Europe.

assistant: **Abstract**

A “gut feeling” is an intuition arising without conscious reasoning. This idiom reflects a profound biological truth: the gut is directly connected to subcortical systems that regulate arousal, mood, and behavior. However, brain-body theories often overlook these connections and their influence on arousal, a key mechanism through which the gut affects cognition. Moreover, we lack a detailed understanding of how different time scales of gut activity -from rapid contractions (seconds to minutes) to slower hormonal fluctuations (minutes to hours)- interact with brain dynamics, mood, and cognition. Critically, this gap also extends to mental health, where gut signals are increasingly recognized for their crucial role, yet a comprehensive mechanistic framework linking specific symptoms to altered brain-gut interactions remains absent.GUT-FEEL will address these challenges by systematically investigating gut-brain interactions across the vigilance, affective, and physiological dimensions of arousal, using pharmacological manipulations of the gut and brain. By combining non-invasive measurements of stomach activity with a dense, hourly sampling of gut hormones, I will probe how fast and slow gut signals interact with brain activity, captured simultaneously through electroencephalography and functional magnetic resonance imaging. This novel approach will allow me to untangle the complex web of interactions between the gut and the brain, both in healthy individuals and in those with depression.By positioning the gut as a critical modulator of brain function, GUT-FEEL will reshape our understanding of the intricate links between the brain, body, and mind. This groundbreaking approach will push the boundaries of cognitive neuroscience and pave the way for gut-focused therapeutic i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Excited and exotic hadron resonances from Quantum Chromodynamics' to be submitted under Horizon 2020.

assistant: **Abstract**

This project will investigate the newly observed and poorly-understood `XYZ' resonances seen in the spectrum of charmonium resonances around the open-charm threshold. These states are difficult to explain in a simple quark model and a full understanding of their nature requires lattice quantum chromodynamics to provide an ab-initio framework. One important candidate to describe some of these states is a tetraquark configuration of a bound charm quark and anti-quark coupled non-trivially to a light quark and anti-quark. The technical expertise to perform these lattice calculations has only recently been developed and it will be tested and extended in this collaborative project by combining the expertise of the fellow and the PI. To understand the nature of unstable states at thresholds for strong decays requires the lattice calculation of multi-meson states interacting in finite volume and analysed using the Luescher method, extended to include coupled-channel scattering amplitudes. These new techniques, pioneered by the fellow will be applied for the first time to study charmed mesons in D-Dbar and Ds-Dsbar scattering in the energy range relevant for studies of the mysterious XYZ resonances.


**Keywords:** Hadron physics, exotic mesons, resonances, Lattice QCD, coupled-channel scattering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cardiac Uptake REstoration of Glucose in diabetic Heart Failure' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Heart failure (HF) affects over 64 million people worldwide and is a leading cause of hospitalization and premature death. About 40% of HF patients also have type 2 diabetes, doubling mortality risk. In HF, the stressed myocardium shifts toward glucose metabolism, but in diabetes cardiomyocytes fail to take up glucose and remain reliant on fatty acids, leaving the heart energy-starved. Current HF therapies target neurohormonal pathways to reduce workload and slow progression but do not address this root metabolic defect. Insulin and GLP-1 receptor agonists can influence glucose metabolism, but their use in HF is limited by side effects, lack of direct cardiac efficacy, or even potential harm. CURE-HF proposes a novel approach by developing small-molecule inhibitors of a newly identified gene. Patient data revealed that this gene was the most differentially expressed in patients with heart failure and diabetes compared to heart failure patients without diabetes. Knockdown of this gene in hiPSC-derived cardiomyocytes increased glucose uptake, while mice lacking this gene on a high-fat diet with induced HF had better glucose control and 20% higher myocardial glucose uptake by FDG-PET and a better cardiac function. These findings demonstrate that inhibition of this gene restores energy balance and protects against diabetic HF. Building on these insights, CURE-HF will design and optimise selective, safe, and synthetically accessible small molecules to inhibit the newly identified gene. Lead compounds will be validated in human iPSC-cardiomyocytes and in diabetic HF mouse models, with functional readouts including glucose uptake, echocardiography, and FDG-PET. In parallel, the project will secure IP, engage stakeholders, and assess market potential. By addressing the root ene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pleiotropic treatment of cancer: RANK inhibitors targeting cancer stem cells and immunity' (PLEIO-RANK).

assistant: **Innovation**

Thousands of cancer patients worldwide are taking RANKL inhibitors for the management of bone metastasis, based on the key role of RANKL and its receptor, RANK, in osteoclasts. RANK signaling has multiple divergent effects in immunity and inflammation, both in the generation of active immune responses, as well as in the induction of tolerance. We showed that RANK overexpression induces stemness and interferes with differentiation in non transformed mammary epithelial cells and promotes mammary tumorigenesis, acting as a paracrine mediator of progesterone. However, the therapeutic potential of inhibiting RANK signaling once tumors develop and its effects on tumor immunity remain unexplored. Our proposal tackles novel concepts: Is RANK a better therapeutic target than RANKL? Does RANK induce ""stemness"" in other epithelia and solid tumors and how? Does RANK regulate the tumor-immune cell crosstalk? Would inhibition of RANK signaling in tumor and immune cells result in synergistic or opposing effects on tumor outcome? We hypotesize that RANK activation in solid tumors expands the cancer stem cells pool and induces an immnunosuppressive environment leading to tumor recurrence and metastasis. In PLEIO-RANK we aim to:1. Define the contribution of RANK to the epithelial hierarchy in mammary, skin and colon, during homeostasis and tumorigenesis, undertaking lineage tracing approaches.2. Dissect the impact of RANK loss in the epithelial or the immune compartment in tumor outcome, exploiting tissue inducible models, in breast cancer and solid tumors driven by chronic inflammation.3. Validate the clinical implications of our findings using patient derived xenografts and human tumor samples. Based on the results of our proposal RANK inhibition could become a unique targeted therap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of an integrated system for controlling water vapour generation in baking ovens for sme sub-system manufacturers' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The European market for bread and other baked goods is large and mature and des pite favourable economic conditions and trends toward premium priced products, the commodity nature of most bread products, continues to place significant cos t pressures on manufacturers. Hence, the reduction of manufacturing costs and i ntroduction of cost effective quality improvements is key to the commercial bak ers' efforts to remain profitable. One of the largest areas for potential savin gs and quality improvements relates to the potential to replace the current use of remotely generated steam to create increased humidity environments in the ' wet' section of the process, with a more controllable and energy efficient medi a method. Commercial bakeries currently use a centralised high pressure stea m generation and distribution system to produce the water vapour atmosphere wit hin the wet section of the oven. This method is highly inefficient, and yield s poor control over processing conditions, in comparison to most industrial mat erials processing technologies. Indeed, it is commonly accepted by commercial b akers that the energy losses using this method are excessive but unavoidable. W ork carried out by ETSU (The Energy Technical Support Unit ), confirmed that th e energy used to generate vapour in commercial bakery ovens currently accounts for 25%-40% of the total used in the process. Up to 50% of this figure is subse quently lost in generation and transfer inefficiencies. For a typical large tra velling oven rated at 7000 loaves per hour, the energy loss equates to 23,O00 E CU per year. Scaled up to the European level, the potential losses are between 50 and 100 M ECU, representing an energy content of 6000 to 1000 Tera Joules pe r annum. In addition, the use of steam to provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis and Biological Evaluation of a Potent Antituberculosis Natural Product and Analogues' (TBKO), addressing dissemination and exploitation.

assistant: **Impact**

This project is directed toward the total synthesis and full structural elucidation of an epidithiodiketopiperazine natural product endowed with highly potent antituberculosis properties and whose full structure and biological evaluation remain incomplete due to its natural scarcity. The proposed research program also includes design, synthesis and biological evaluation of novel analogues of the target molecule as part of an optimization effort, and attempts to identify its biological target.The first year of research and training will be conducted under the supervision of Prof. K.C. Nicolaou (Rice, USA), where the synthesis and compound characterization part of the project will be pursued. In the return phase, the applicant will go to Geneva to work under the supervision of Prof. N. Winssinger (University of Geneva, Switzerland) where the synthesis of the analogues will be performed. The compounds synthesized will be tested for biological activities and evaluated for growth inhibition in a panel of mycobacteria (screeni available through Prof T. Soldati at Geneva).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Numerical Design of Self Assembly of Complex Colloidal Structures'.

assistant: **Objectives**

I propose to use computer simulations to predict the thermodynamic stability and kinetics of formation of three-dimensional structures of DNA-linked colloids. I then aim to go beyond simple binary structures and use simulation to explore novel strategies to build multi-component three-dimensional colloidal structures.  At present, the complexity of self-assembled colloidal crystals is limited: ordered structures with more than two distinct components are rare. To make more complex structures, particles should bind selectively to their designated neighbours. This may be achieved by coating colloids with single-stranded DNA that hybridises selectively with the complementary sequence on another colloid. However, there are many practical obstacles to go from there to the self assembly of multi-component structures. In order to make progress, we need to understand the factors that determine the thermodynamic stability and, even more importantly, the kinetics of formation of complex structures. Such a numerical study will require a wide range of numerical techniques, many of which do not yet exist.  As I have played a key role in the development of the numerical methods to study both the stability and the kinetics of formation of simple colloidal crystals, I am well positioned to make a breakthrough that should have important implications for experimental work in this field. My research will focus on DNA-linked colloidal systems, as this is an active area of experimental research. However, I stress that many of the techniques that I aim to develop are general. During the project, I aim to study the factors that influence the equilibrium phase diagram and the kinetics of passive and active self-assembly of (multi-component) DNA-colloid systems During the project, I aim to stud
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional resolution of industrially important gas mixtures using low cost multi-faceted gas sensors' under Fourth Framework.

assistant: **Concept**

Objectives and content The industrial need for the RTD work here proposed arises from the continuing pressure from industry and Society for low cost gas sensors which can be used for a wide range of applications which can be broadly classified as improved air quality". These markets are in part being driven by legislation and regulation. Existing and emerging markets now require from these components the demanding combination of a significant improvement in performance at a much lower price. The multiple facets of the planar solid state gas sensors which unify this proposal are: multiple electrodes underneath multiple layers of sensor material, each layer with controlled microstructure so as to optimise the performance of the device. Electrode spacing, overall device geometry and microstructure are optimised so as to create, in effect, a crude but inexpensive gas chromatograph for resolving mixtures of molecules, as found in the "real world". The objective of the work is to establish and demonstrate a sound technological basis for the optimisation of the design and manufacturing processes for the sensors, and to fabricate them and demonstrate their suitability, in association with appropriate signal processing electronics, for the multi-sectorial applications identified by the user Partners. None of the important industrial (and environmentally significant) target applications can be resolved using current sensor technologies, though the potential of the technology here proposed to achieve this objective has been demonstrated. The optimised devices will be subsequently designed into solid state sensor systems ranging in complexity from the relatively simple and low cost to electronic noses. The designing-in phase is likely to take 2-3 years following completion of the w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Boosting the performance of Quantum Chemistry for nanocatalysts, biomolecules and graphene layers by solving the fundamental drawback of van der Waals interactions in Density Functional Theory'.

assistant: **Concept**

The goal of the proposed IEF project is to develop a novel Density Functional Theory (DFT) method, which will facilitate the very efficient investigation of large macromolecules. DFT is the most used quantum chemical method today, as it allows, at a low computational cost, to perform research at a quantum chemical level on systems containing up to thousands of atoms. However, standard DFT only includes a poor description of dispersion interactions, which occur in systems such as peptides, DNA base-pairs, graphene layers and heterogeneous catalysts.To overcome this great disadvantage the IEF will:a) transform a model for evaluation of dispersion energies at DFT level into a pragmatic and accurate methodology.b) implement the methodology, through design and application of advanced computational chemistry techniques into an efficient and user-friendly software.c) apply this novel DFT method on high-profile problems (nanocatalysts, biomolecules, graphene layers)The results will directly impact research in biochemistry, material science, catalysis and supramolecular chemistry boosting fast and accurate studies on numerous macromolecular systems.The applicant is an expert in DFT, who will complement her skills in Computational Chemistry and  design of methods within the Theoretical Chemistry Group at the University of Kaiserslautern (Germany), who are leading scientists in the field. These investigations will allow the fellow to acquire excellent expertise in a pioneering research topic, which is of crucial importance for the worldwide efforts for using macromolecules in innovative technologies. In combination with the complementary training, this IEF project will help the applicant to obtain scientific maturity and actively participate in shaping future research regarding DF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Talent and Extended Mobility in the European Innovation Union' in the context of a Seventh Framework call.

assistant: **Objectives**

Mobility represents a key factor at the early stages of researchers’ careers. Over the last years the European Union has started a number of initiatives to facilitate mobility in the European Research Area, most prominently the EURAXESS Services Network. The TANDEM proposal aims at strengthening these activities by adding a complimentary focus on dual career aspects.In growing numbers young researchers are on the move as dual career couples. Therefore universities and research institutions are challenged to accommodate the needs and ambitions of dual career couples if they want to attract the most talented young researchers. Thus the attractiveness of universities and research institutions is no longer defined just by an excellent research environment, but by additional practical integration factors and most of all career prospects for both partners.TANDEM will analyze the basic requirements for the successful implementation of Dual Career and Integration Services (DCIS) and develop a systematic and modular approach to these services which will allow universities and research institutions in the ERA to put together a customized set of DCIS according to their specific needs, goals, social and cultural border conditions. Besides, TANDEM will focus on brain circulation and how DCIS change a brain drain into a brain gain situation.While it is true that both men and women are affected by mobility, it is acknowledged that it is more difficult for women to successfully pursue a scientific career when they have to reconcile work and home responsibilities. By implementing well structured DCIS it will be possible to prevent young women researchers from abandoning a promising scientific career just because they are faced with insurmountable obstacles. Thus TANDEM will contribute t