RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Narrative Epileptology: A Discourse Analytical Study of Epilepsy Aimed at Clinical Applicability' under Seventh Framework.

assistant: **Concept**

The medical management of epilepsy has enormously progressed since the introduction of specific anti-convulsants in the 1970s and surgical treatment for worst cases, but social and personal adjustment of patients remains problematic. The ominous cultural history of this condition corroborates that prejudice and discrimination towards people with epilepsy are still widespread worldwide. Successful treatment of epilepsy therefore requires to extend beyond the achievement of seizure control to patients’ full acceptance by, and participation in, society. Our hypothesis is that if epilepsy were to be better understood within its chain of intertextuality, neurologists could improve the efficacy of their practices, by adopting a narrative approach alongside biomedical therapies of the condition. We will explore how a critical discourse analysis of epilepsy can enhance current epileptology by engendering narrative awareness and skills. Initially, we will trace the outline of the contemporary epilepsy discourse in Europe, and verify how stigma and problems of doctor-patient miscommunication are inscribed, enacted and/or resisted in it, examining literary works, recordings of interviews and therapeutic conversations. A catalogue of sociolinguistic and narrative practices will be compiled, creating a frame of reference for a tentative formulation of a programme of ‘narrative epileptology’. By means of reading, literary analysis and reflective writing, this curriculum will enhance neurologists’ interpretive skills and encourage a newly informed engagement with their clinical work. A narrative-informed approach to people with epilepsy could ultimately broaden the impact of traditional neurological therapies, providing patients not only with more personalized treatments, but also wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Analysis of gene expression in differentiating neurons using a cdna microarray approach.' (1998-2002).

assistant: **Innovation**

The subject of this study is mRNA expression profiling of differentiating murine hippocampal neurons. A cDNA microarray approach will be used to simultaneously quantify expression levels of about seven thousand of mRNAs at morphologically and functionally defined stages of neuronal differentiation. A culture system will be used in which neurons undergo differentiation, in a well-coordinated manner, to a fully polarised pyramidal phenotype with functional synapses. The objectives of this study are:1. quantitative analysis of expression of a large mRNA set at defined stages of neuronal differentiation2. Identification of genes that are regulated in the differentiation process3. Cluster analysis of genes according to their expression patterns. The results of this project will form a basis for future work; on regulatory mechanisms underlying coordinated expression of genes in differentiating neurons; and on functional relationships of protein products of the developmentally regulated genes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DNA-Authenticity & Traceability for Extra Virgin Olive Oil: Τrust the DNA, the label.' under Horizon 2020.

assistant: **Concept**

Globalization and internationalization of Olive oil industry increased supply chain complexity that led to a fragmented visibility of the involved actors, enabling fraudulent practices for illegitimate profit. In this context, particularly extra virgin olive oil (EVOO), due to its high price coupled with its health benefits and its increasing demand in cosmetic/pharmaceutical sectors became an ideal target for frauds. EVOO traceability is considered a central issue for the identification of improper actions along the olive oil supply chain, to protect its quality and consumers’ health. The aim of AUTHEVOO is to disrupt the EVOO supply chain by providing an end-to-end DNA-based system offering transparency and trust among its actors. To achieve this AUTHEVOO integrates EVOO DNA authenticity and DNA traceability in a real-time portable PCR device capable to identify the varieties in EVOO and its origin. Our current forecasts and analysis show that AUTHEVOO has the ability to generate revenues of ~10M€, with a ROI of 36.30, and to create at least 31 high-educated new jobs by 2023, revealing a high business potential. This project aims to perform a 6-month feasibility study following the TELOS concept (technical, economic, legal, operations and schedule), in order to extensively validate the AUTHEVOO Minimum Viable Product (MVP) and business plan, leading to the creation of a viable commercial strategy that will enable the full exploitation of its market potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting the Oncogenic hEag1 Ion Channel: Developing Venom Peptide-Based Pharmacological Tools' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The human ether à go-go 1 (hEag1) ion channel, also known as Kv10.1, is a voltage-gated potassium channel that is highly expressed in the brain but remains largely absent in other tissues under healthy conditions. However, during cancer development, hEag1 is significantly upregulated in various tumours, making it a potential biomarker and therapeutic target. Its role in cancer, particularly in breast cancer, is still not well understood, which makes exploring hEag1 a critical focus of my research.In this project, I aim to discover and develop the first series of selective hEag1 ligands that can be used as pharmacological probes and therapeutic leads to investigate the channel's function in breast cancer. Building on preliminary data, I will utilize the rich pharmacological diversity found in animal venoms to identify novel peptide ligands that target hEag1. Through structure-activity relationship (SAR) studies and advanced medicinal chemistry, I plan to enhance the potency and selectivity of both newly discovered and existing ligands. These optimized compounds will enable me to explore the functional role of hEag1 in breast cancer progression and assess its therapeutic potential.By integrating peptide chemistry, pharmacology, and preclinical methodologies, this research will pave the way for the creation of highly specific hEag1-targeting probes and drugs. The ultimate goal is to deepen our understanding of hEag1's role in breast cancer and unlock new avenues for targeted cancer therapy, especially for aggressive forms like triple-negative breast cancer.


**Keywords:** Toxinology,  venom-derived peptide,  voltage-gated ion channel,  electrophysiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'European Value Chains for CO2'.

assistant: **Concept**

The main objective of ECCO is to facilitate robust strategic decision making regarding early and future implementation of CO2 value chains for Europe in the face of uncertainty.  The project will provide recommendations enabling cost-effective use of the CO2 being produced from zero-emission power plants and other industries in Europe by exploring the assets and challenges of CO2 for enhanced hydrocarbon production (EOR/EGR) in a value-chain context.   ECCO responds to the need for a European joint effort towards overcoming the barriers to the deployment of CCS. The core group of the project is constituted by 18 legal entities, all of them committed to the execution of ECCO. These encompass 7 energy providers (oil & gas companies and utilities), 2 engineering companies, 1 NGO and 8 highly ranked RTD providers representing bordering countries around the North Sea basin and in Central and Eastern Europe.   ECCO -short for “European Value Chain for CO2”- is designed as a Collaborative Project (small to medium scale focused project). The R&D activities are structured in four sub-projects (SP) directly responding to the objectives of the Work Programme:  • SP1 ECCO dissemination and training • SP2 CCS analysis and recommendations • SP3 CO2 value chain methodology and tool development • SP4 Reservoir technology for EOR/EGR  The knowledge, methods, and tools developed in ECCO shall influence future CCS initiatives by enabling the industrial players and the authorities to analyse, understand, and make sound decisions within the topic of CO2 value chains.  Key expected impacts of ECCO, all complying with the Work Programme are:  • Underpin the realisation of CO2 value chains for captured CO2 from large point sources for CO2 injection in petroleum reservoirs (EOR/EGR) and CO2 sto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advancing orbitronics by pushing electron orbital angular momentum to terahertz speed' (ORBITERA), addressing dissemination and exploitation.

assistant: **Impact**

The spin angular momentum (S) of the electron has significantly extended conventional electronics, which relies on the electron charge (C), by new, so-called spintronic functionalities. Examples include magnetization switching, the transport of S and its detection, even down to femtosecond time scales. To boost the efficiency of spintronics, the so far neglected yet equally fascinating and important orbital angular momentum (L) of electrons is considered to be a powerful pathway. Orbitronic phenomena such as L-based transport, torques and magneto-optic effects have much larger magnitude than their S counterparts and may, thus, efficiently complement or even replace spintronic functionalities. Microscopically, L is completely different from S. Its dynamics involves new physics that needs to be understood, in particular on ultrafast time scales.In the ORBITERA project, my team and I will obtain unprecedented insights into L dynamics by using femtosecond optical pulses and terahertz (THz) electric fields, which couple directly to the motion of conduction electrons at their natural frequencies and relaxation rates. We will tackle important challenges of general orbitronics and, in particular, separate L- and S-based effects despite their identical macroscopic symmetry properties, build ultrafast generators and detectors of exclusively L currents, reveal the nature of L transport (e.g., ballistic, diffusive, tunneling), measure the magnetic moments forming an L current, probe the interaction of L with the crystal lattice, temporally resolve L-S and L-C interconversion, and apply THz L torque to ultimately switch magnetic order ultrafast.By establishing THz orbitronics, new methodology (such as ultrafast drivers of L currents and L-conductance spectroscopy at 0.1-50 THz) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering of Energy Efficient Extraction of Critical Materials- Application to the Processing of Niobium and Tantalum Minerals' (E4-CritMat).

assistant: **Innovation**

Current situation: European Union (EU), economic growth is threatened by the unsecure supply of materials which affect main sectors of the economy such as the energy, health and digital. Historically the main resources of such mineral are located in few countries which either suffer from weak political structure or, belong to the growing economies in which the national strategies are promoting unfair competition especially in EU, thereby smothering growth within. Research Project Objectives: The E4-Crit-Mat MC is going to explain the general principles for demonstrating environmentally clean minerals and chemicals processing, which is based on alkali roasting treatment of mineral concentrates at elevated temperatures (900oC), followed by leaching and recovery of alkali by recycling CO2 and further refining. In E4-CritMat we primarily focus on the processing of Nb and Ta minerals, as a case study because of their importance in the EU’s micro-electronics, communication, and aerospace industries. Training Objectives: 1. Technological training involving high-temperature, aqueous chemical processing and characterization techniques, 2. Training in a business environment and learning its culture including exploitation and process economics analysis at the London & Scandinavian Metallurgical co in UK, 3. Enterprise training courses and its applications in industry for technology exploitation including the patent filing and licensing, 4. Environmental aspects of process engineering in mineral industry.  Impact expected: 1. Provide the MC Fellow with the tools needed to reach a professional maturity. 2. Strengthen the EU companies in the market for Critical Materials via long term relationships with Brazil and helped in reducing significant environment impact.   3. Reduce the dep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'NEW GOALS AND DIRECTIONS FOR OBSERVATIONAL GLOBAL SEISMOLOGY' (GLOBALSEIS).

assistant: **Innovation**

One of the major paradoxes in the geosciences is the contrast between the geochemical evidence for limited mass-exchange between lower and upper mantle, and the geophysical arguments for significant mass exchange, needed to prevent the mantle from melting in the geological past. Seismic tomography, when ultimately combined with geodynamical modeling, needs to provide estimates of present-day flux. Indeed, tomography has shown evidence for slabs penetrating into the lower mantle; but no quantitative information on the degree of mass exchange and heat flux can, as yet, reliably be obtained from tomographic images.  It is crucial that the boundary between upper- and lower mantle be imaged at greater precision, certainly in the plume-rich southern hemisphere. This requires a combined effort of improvements both experimentally and theoretically. Much progress has recently been obtained by my group in Princeton before I returned to Europe. I propose to build upon those accomplishments, and to (1) Expand the data acquisition to the oceans by developing hydrophone-equipped floats, with the goal to improve data coverage in regions that are important to investigate heat flux: the plume-rich southern hemisphere in particular, (2) Combine different seismological data sets spanning a wide range of frequencies, with the goal to obtain tomographic images that allow for a quantitative estimate of heat flux (both upwards through plumes and downwards through the sinking of slab fragments), with emphasis on the boundary between upper- and lower mantle, (3) Exploit the extra resolution offered by the frequency-dependent sensitivity of body waves (multifrequency tomography), (4) Incorporate wavelet expansions into the tomographic inversion, with the aim to resolve more detail in the model w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling cortical information flow during visuomotor adaptation as active inference in the human brain' (ViMoAct).

assistant: **Concept**

Recent research suggests that to control bodily movements the brain relies on Bayes-optimal predictive models that are updated by sensory prediction error. This assumption may be generalised within a new formal account of motor control as active (Bayesian) inference. Active inference explains motor control in terms of hierarchical Bayesian filtering or predictive coding, i.e., as belief updating and suppression of prediction error to optimise a hierarchical generative model in the brain; thereby the weighting of prediction errors by their predicted precision determines their relative impact on hierarchical inference. This novel proposal still lacks concrete empirical investigation. The proposed project will close this research gap by testing whether cortical information flow during manual actions, requiring visuomotor adaptation and cognitive control of attention, follows the principles of active inference. In two fMRI experiments and one MEG experiment, participants will move a photorealistic virtual hand model via an MR-compatible data glove to perform simple manual tracking tasks in a virtual reality environment. The precision of prediction errors at multiple levels of a previously established cortical motor control hierarchy will be experimentally manipulated via visuoproprioceptive conflicts (introduced by delayed visual movement feedback) and via attentional allocation – either stimulus-driven (via increased sensory noise) or endogenous (instructed) – to visual or proprioceptive movement feedback. Active inference’s specific predictions about information flow between and within cortical areas will be tested with recently established dynamic causal modelling of the modelled hemodynamic (fMRI) or spectral (MEG) responses. Active inference appeals to a general free-e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a methodological tool to enhance the precision & comparability of solid waste analysis data (S.W.A. - TOOL)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Waste analyses are a widely used tool for acquiring relevant information for waste management planning, and for increasing the efficiency & effectiveness of planned measures. Despite relevant efforts, waste analyses have not been satisfactorily standardized to date. This leads to deficient data quality, resulting in planning errors as well as difficulties in comparing the effect of different waste management measures. In the RESEARCH PART, a consortium with nine participants from different European regions will develop a methodological tool for waste analyses, with a view to improving the accuracy & comparability of analysis data. Extensive dissemination is to help promote use of the tool and contribute to the standardization of waste management data. In the DEMONSTRATION PART, the tool will be tested in practice on a number of occasions and modified on the basis of this information. The analyses will serve as reference projects for the dissemination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MEtal-SIte engineering in Single-Atom Catalysis for efficient transfer hydrogenation' (MESISAC).

assistant: **Innovation**

The semi-hydrogenation of unsaturated aldehydes to alcohols is a key step in fine chemical production. Existing catalysts based on noble metal nanoparticles, however, suffer from high cost, low selectivity, and deactivation, while the use of molecular hydrogen requires harsh conditions. Catalytic transfer hydrogenation (CTH) with renewable hydrogen donors like formic acid offers a safer and milder alternative, yet efficient, stable, and cost-effective catalysts remain elusive.In MESISAC, I will design non-noble metal single-atom catalysts (SACs) on covalent organic frameworks (COFs) with tunable functional groups to control metal coordination, targeting >80% conversion, >90% selectivity, and stability over ≥5 cycles. Detailed kinetic and mechanistic studies, including isotope labelling and structure-reactivity relationships, will clarify the reaction pathways.A distinctive feature of MESISAC is the integrated training program, which combines hands-on expertise in materials synthesis, advanced operando spectroscopy (XAS, NAP-XPS), and computational modeling, with the development of transferable skills such as project management, scientific communication, and interdisciplinary collaboration. This structured training, supported by secondments at the SOLARIS synchrotron and exposure to industrial partners, will accelerate my scientific independence, boosting my ability to coordinate interdisciplinary research projects while further strengthening my leadership, problem-solving, and innovation skills.The project will be hosted at the Department of Chemistry, Materials and Chemical Engineering of POLIMI, providing access to state-of-the-art synthesis, characterization, and catalytic testing facilities. By combining advanced materials design with in-depth mechanistic insight an