RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety and Protection of built Infrastructure to Resist Integral Threats' (SPIRIT) under Seventh Framework.

assistant: **Objectives**

Terrorist attacks by bombing or CBR-agents are threats with a low probability but with disastrous consequences. There is strong need to protect people, the societal community and critical infrastructures and utilities against being damaged, destroyed or disrupted by deliberate acts of terrorism. Solutions have to be derived to realize sufficient resilience of the urban infrastructure for rare occasions with minimum effect on normality. Hitherto, normal regulations and building guidelines do not take into account the CBRE threat. Fortunately, the required specialist knowledge is available on explosion dynamics, response of structures, dispersions of toxic agents and the injuries. This knowledge should be explored to derive the required solutions. Therefore, the SPIRIT Consortium was formed to bring the required expertise together, make these commonly available and to find solutions that can be integrated into normal life and planning and building procedures. Within SPIRIT a terrorist attack with the whole scope of CBRE-threat is addressed. The main outcome of the project is an integrated approach to counter CBRE-threats, including proposed guidelines for a EU Regulatory Framework. With this approach, government, end users of buildings and designers can define and achieve a desired level of protection. The SPIRIT contribution to built infrastructure protection will be: - A methodology to quantify the vulnerability of built infra in damage, number of injuries and loss of functionality and services; - A guidance tool to assess the vulnerability and define efficient and effective countermeasures to achieve a required protection level; - Draft guidelines to enable safety based engineering and the incorporation of CBRE protection; - A suite of ready to use CBRE countermeasure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultra-high-Q Physics: Towards single molecules and phonons' (SIMP) under Seventh Framework.

assistant: **Objectives**

The proposed research program builds on the previously developed ultra-high-Q monolithic micro-resonators by the applicant during his dissertation at the “California Institute of Technology”. These micro-resonators offer unprecedented confinement of light in micro-scale volumes for extended amounts of time and have opened many lab-on-chip applications ranging from nonlinear optics, quantum optics to biochemical sensing. This present proposal is concerned to use ultra-high-Q optical micro-cavities as vehicles to study two novel and emerging research opportunities. The first endeavor investigates the possibility to use radiation pressure to cool a mechanical oscillator to the quantum ground state. The significance of the research program lies in its attempt to exploit the opto-mechanical system as a paradigm for the investigation of quantum processes of mechanical objects – a field which has sparked widespread interest in contemporary physics for quiet some time, but which to date remains experimentally unexplored and which is intimately related to concepts used in fields such as gravitational wave detection or scanning probe techniques. From a conceptual point of view, this research could show how a mechanical, macroscopic object reveals quantum mechanical behavior. Ultra-sensitive measurements are also part of a second, interdisciplinary line of research. To date, only a few widely applied techniques in Biophysics are available for label free detection of ligand-receptor binding, which lack single to resolve single molecule binding events. Building on recent advances of the applicant, the proposed methodology will use membrane functionalized micro-resonators in aqueous solution as novel technique to resolve single binding events. By developing a methodology with which l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Control of Programmed Cell Death by Metacaspases in plants' under Seventh Framework.

assistant: **Concept**

Plant pathogens devastate crops resulting in yield losses and increasing the use of often unsustainable pesticides. Understanding the basic mechanisms of the plant immune system will increase our ability to successfully combat plant diseases, satisfying the growing needs for sustainable food production, a future challenge for European agriculture.Cell death has a central role in innate immune responses in both animals and plants. The hypersensitive response (HR) is a plant-specific form of programmed cell death (PCD) occurring at the site of attempted pathogen invasion. A tight regulation of HR is essential in order to avoid unnecessary tissue damage beyond the infection site. However, the signaling pathways leading to HR still remain ill-defined. We have recently shown that Arabidopsis metacaspases, distant homologs of animal caspases, antagonistically control pathogen-triggered HR. However, their precise mode of action, regulation and substrates remain largely unknown. With this project we will use a combination of proteomic, genetic, cell biology and biochemical approaches to dissect the mechanisms underlying PCD control by this family of proteins. Defining the first plant deathosome will be a major breakthrough in plant sciences, moving forward with knowledge that can be directly translated into agronomically relevant species.We will use a multidisciplinary approach, benefitting from transnational collaborations already established by the candidate with research groups located in Europe and the USA. A Marie Curie International Incoming Fellowship will ensure the continuity of the candidate’s high-impact research at the host institution, an emerging reference center for plant sciences in Spain. Reintegration of the candidate will complement and synergize with the exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Studying the role of the retrosplenial cortex in flexible learning' (REFLEX), addressing dissemination and exploitation.

assistant: **Impact**

An emerging view of cortical area function posits that instead of primarily accounting for sensory processing and motor control, cortical areas might mediate flexible handling of sensory information and motor planning through learning and memory. In this project I propose to investigate this notion focusing on the function of retrosplenial cortex (RSC), a large, poorly understood and highly interconnected cortical area that interfaces with the hippocampal system. RSC has a key role in memory, and is thought to control flexible use of contextual information; it accounts for earliest memory deficits in Alzheimer’s disease. In primates, the RSC is positioned immediately behind the splenium and is centrally located between cortical sensory and limbic memory regions. It exhibits reciprocal connections with the hippocampal for-mation, anterior thalamic nucleus, and a network of dorso-medial cortical areas. RSC has a critical role in spatial and relational memory, and its interactions with the hippocampal system are essential for normal memory processing. The focus of this project is the hypothesis that the connectivity patterns of RSC account for what has been called its “translational” properties. I will first study the role of RSC in a generic form of flexible learning, then I will focus on spatial learning and analyse the capability of RSC to integrate information across multiple cue types and use these inputs to deal with the environment e.g. in allocentric-egocentric and egocen-tric-allocentric transformations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of fluid inclusion analysis as a tool for predicting the occurrence of high-grade gold ore shoots' in the context of a Fourth Framework call.

assistant: **Objectives**

Erratic and unpredictable distributions of gold impose serious limitations for the successful prospection and exploitation of gold deposits. The problem is especially acute in Europe where the average grade of mesothermal gold-quartz veins, one of the principal targets for SME mining companies, falls below lOg/t gold. The formation of these low-tonnage high-grade deposits is well understood and, on a regional scale, potential ore zones can be identified using conventional exploration techniques. However, on the scale of individual veins, current metallogenic models cannot predict the location of discrete high-grade ore shoots that determine the economic viability of the deposits. This increases investment risk and discourages SME exploration activity in the EU. Strong circumstantial, evidence suggests that the formation of high-grade ores does not conform to the general mesothermal gold model. but is the result of remobilization and enrichment by low temperature fluids. By using an integrated Fluid inclusion mineralogical and microstructural approach it is proposed to demonstrate that (1) remobilization plays a critical role in the development of high-grade ores and (2) enrichment leaves a diagnostic geochemical and structural fingerprint that can be detected and used to predict the location of high-grade ore shoots. The industrial objective of the research is to provide a cost-effective geochemical exploration tool that locates high-grade ore shoots in mesothermal gold-quartz veins using drill-core samples. Two technical innovations are required to meet this objective. First, there is a need to develop new detection methodologies based on the integrated geochemical and microstructural signature of vein quartz. These will assist in geostatistical modelling and provide m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Clinical Development of Advanced Therapeutic Medicinal Product for Acute Kidney Injury' (ALOREN).

assistant: **Innovation**

Acute Kidney Injury (AKI) is a global health issue, costing over €300 billion annually, and has a seven-fold higher risk of developing chronic kidney disease (CKD), which is projected to be a leading cause of death by 2040. AKI affects up to 40% of patients undergoing cardiopulmonary bypass (CPB) surgery, with currently no effective treatment.   We developed an innovative, immunomodulatory, scalable, placental stem cell-based Advanced Therapeutic Medicinal Product manufacturing platform to address the pressing need for effective treatment of CPB-AKI and prevention of CKD. Our clinical-grade bioprocessing platform and a lead compound, KELI-101, validated by positive preclinical data, demonstrated a breakthrough potential to significantly enhance survival, improve both functional and structural kidney recovery, reduce inflammation and prevent CKD. In addition, the multifactorial mode of action of KELI-101 enables its use to treat various inflammatory conditions. Implemented GMP-grade processes ensure consistent product quality and scalability, reinforcing KELI-101’s potential as a transformative therapy to address critical unmet medical needs globally.   Our seasoned global expert team, combined with strong partnerships with global CROs and leading European clinical sites, enables us to efficiently drive an international Phase 1b/2 multicenter adaptive efficacy and safety trial for KELI-101. These efforts are aligned with the European Medicines Agency regulatory requirements, positioning us to successfully obtain marketing approval and bring this innovative therapy to the market.  A strong business model approach with European medical centers and health systems, improved patient outcomes, decreased healthcare costs, reduced CKD prevalence, and multifunctional applicabilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'science, education and learning in freedom' under Sixth Framework.

assistant: **Concept**

The SELF platform aims to bring together educational institutes, training centres, software companies, publishing houses, government bodies and Free Software communities to centralise, create and disseminate educational and training materials on Free Software and Open Standards.This project starts from three main assumptions: 1) Free Software and Open Standards are crucial to support the competitive position of the European software industry; 2) the real and long term technological change from private to free software can only come by investing in education and training; and 3) the production of educational and training materials on Free Software and Open Standards should be done collaboratively by all the parties involved.The SELF platform will be simultaneously a knowledge base and a collaborative production facility. On the one hand, it will provide educational and training materials that can be presented in different languages and forms: from course texts, presentations, e-learning programmes and platforms to tutor software, e-books, instructional and educational videos and manuals. On the other hand, it will offer a platform for the evaluation, adaptation, creation and translation of these materials. The production process of such materials will be based on the organisational model of Wikipedia. In short, SELF will be a web-based, multi-language, free content knowledge base written collaboratively by experts and interested users.While the SELF platform will be started by the members of the consortium, its final goal is to become a community of different interested parties (from governments and educational institutes to companies) that can not only exploit the SELF materials but also participate in its production. The commercial and educational interests of exploiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Air pollution and inflammatory response in myocardial infraction survivors : gene-environment-interactions in high-risk group'.

assistant: **Innovation**

The aim of the proposed study is to determine the association between ambient air pollution and inflammatory responses as markers of early biological effects and to address the individual susceptibility in myocardial infarction survivors. 1200 patients will be repeatedly examined in six European cities (Athens, Augsburg, Barcelona, Helsinki, Rome, Stockholm) within an 8-month period. Ultrafine particle measurements will be conducted and traditional air pollution concentrations will be obtained from the local air hygiene networks. Inflammatory markers and single nucleotide polymorphisrns will be determined in a core laboratories. The data will be analyses with time-series methods. Gene-environment interactions will be analysed for subgroups as mandated by the epidemiological design. The results are relevant for European initiatives to implement targeted prevention strategies on air pollution and to release evidence based guidelines for high-risk populations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Experimental and theoretical investigations on the microtubule-mediated formation of intracellular protein patterns' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

A key question in modern cell biology is how intracellular spatial order is established and maintained. Here, we propose to investigate the physical principles of the formation of intracellular protein patterns, using a multidisciplinary approach that combines quantitative live-cell imaging with computational modeling.As an in vivo model system we will use fission yeast, which is distinguished by its extraordinarily well-defined shape and intracellular order. In fission yeast, a dynamic microtubule transport system maintains a highly inhomogeneous distribution of the growth-promoting protein tea1. Perturbing the distribution of tea1 leads to severe defects of cell morphology.We will address the following questions:- How does the dynamic patterning of tea1 depend on microtubule growth and shrinkage dynamics?- What is the spatiotemporal accuracy of tea1 pattering?- How is the transport system affected by cell elongation?- What are the general differences between protein transports along dynamic as opposed to static microtubules?We will address these questions using a combination of both experiments and theoretical analysis. Specifically, we will use confocal spinning disc microscopy to measure the time-dependent 3D distribution of fluorescently tagged tea1, tubul in and other relevant proteins.Based on the data acquired and on existing information, we will formulate a model of tea1 patterning. Predictions following from the model will again be tested experimentally, e.g. using drugs or genetic modifications to perturb the system.This tight link between theory and experiments will provide novel and comprehensive information on generic properties of microtubule-based transport: a process that is of key relevance to protein patterning in most eukaryotic cells.During this pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Simulation, Statistics and Experiments Coupled to develop Optimized aNd Durable µCHP systems using ACcelerated Tests', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Simulation, Statistics and Experiments Coupled to develop Optimized aNd Durable µCHP systems using ACcelerated Tests.Second act aims at improving understanding of stack degradation in order to propose solutions enabling significant lifetime improvements for µCHP systems using PEMFC or DMFC technology. Project will be thus founded and focused on two efforts: degradation understanding and durability improvement. These efforts will be oriented towards existing systems available in the project thanks to the involvement of three industry partners willing to enhance lifetime and hence competiveness for market deployment. Degradation investigations will be based on lifetime tests information from existing field tests on these systems for relevant description of failure modes and related performance degradation; from stack and cells specific degradation/durability tests including validated accelerated stress tests emphasizing specific degradation or failure modes in cells and stacks. Understanding will be ensured by using expertise of research groups in different techniques such as: advanced in-situ local measurements to identify heterogeneities and local performance degradation; ex-situ investigations of components to identify mechanisms; statistical analyses to identify  the impact of failure modes and to relate causes to performace losses; and modelling to simulate local performance and degradation in unit cell and stack.Durability improvement will be assessed thanks to the following methodology: exploitation of all degradation investigations for the proposal of components modifications; selection of most relevant solutions related to most critical degradation issues for their evaluation and demonstration of durability improvements; application of validated accelerated tests