RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Financial Study for Sustainable Computing e-Infrastructures' (2007-2013).

assistant: **Innovation**

Over the last ten years the European countries and the EC have made significant investments in e-Infrastructures for scientific computing, notably High Throughput Computing (HTC) and High Performance Computing (HPC) services. Their contribution in pushing the European research towards a leading position in addressing global challenges has been validated by a growing number of research initiatives, most notably the ESFRI projects. Sustainability of such services is crucial, as the research supported by them is more and more crucial for European competitiveness – and sustainability can be planned better if the costs are known. The emerging commercial offerings (Cloud-based HTC and HPC solutions) pose additional challenges and opportunities for sustainability. They represent new ways of explicit monetisation of computing and open the way to new business models (e.g. service fees or of lease industrial resources). The upcoming next framework programme and broader EU policies depend on more careful impact assessment, which requires accurate cost estimates. Similarly energy saving and green computing will be increasingly relevant, and project results will also allow estimating potential benefits in these areas. It is thus vital to understand the cost of the dedicated computing related e-Infrastructures, as expressed by EGI and PRACE initiatives. The calculation of such costs is not trivial; keeping detailed accounting data for the evolving mix of capital (hardware) and operational (personnel, energy) expenditures is only one of the challenges. The scope of the e-FISCAL proposal is to analyse such costs, facilitated by national entities (NGIs and HPC centres), compare them with equivalent commercial leased or on-demand offerings and provide an evaluation report. The execution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Survey on quality assurance measures and proficiency testing schemes for molecular genetic testing (GENETIC TESTING)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The community's health services face a proliferation of molecular genetic tests, the introduction of a bewildering array of methods to detect any single genetic lesion and potentially many different ways for reporting laboratory findings. These considerations and the increasing trend for tests to cross national boundaries suggest that an international approach to quality assessment, harmonisation and mutual recognition of national and regional schemes is needed. However, significant gaps in data and policy analysis may impede informed international action. The present proposal for a survey across OECD countries is intended as a first step towards international cooperation in this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Breaking oncometabolites dynamics for next-generation dendritic cells tumor immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Owing to an increased appreciation of the potential for immunotherapy in neoplasia, much attention has been focuing on a greater understanding of the immune, bidirectional intricacies involving the Tumor MicroEnvironment (TME). Recent work has demonstrated that TME elicits environmental changes, metabolic in nature, in the host’s immune cells, that dampen their ability to REACT against tumors. Manipulating the biology of oncometabolites can strengthen an antitumor immune response as well as circumvent therapy resistance. Here I propose innovative modalities to tackle this problem. The Aryl hydrocarbon Receptor (AhR), best known as the receptor for dioxins, has recently been shown to be one ""central node"" for communication between host's cells and its ligands, disparate as the nature and source. I have recently found that selective AhR deletion in a subset of antigen presenting cells triggers the rejection of an otherwise progressive fibrosarcoma tumor in vivo. I thus hypothesize that, AhR, expressed in orchestrators of immune responsiveness, represents a key sensor of TME composition, influencing the outcome of an immune reaction against tumors. The main objective of this project is to identify AhR-activating metabolites in TME and disclose their impact on tumor rejection or progression. In parallel, I aim at developing novel advanced strategies, with a high degree of translatability to human cells, to specifically inhibit AhR or AhR-dependent programs in selected APCs. I will combine state-of-the-art technology with new and powerful technologies, including advanced single-cell analysis, promoter gene-editing approaches and computational chemistry. The potential of such a project is very high, because such metabolites may be predictors of immune activation or suppress
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Source-specific ecosystem transfer of actinides utilising advanced technologies' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Knowledge of actinide behaviour in ecosystems is seriously lacking in radioecology. The project systematically compares the influence of source-term and ecosystem characterisation on the mobility and biovailability of actinides in terrestrial, freshwater and marine ecosystems. This will provide fundamental information on mechanisms and key processes influencing actinide transfer, and subsequent implications for dose and impact assessment. Case study sites Palomares, Mayak, Trish Sea, Semipalatinsk and Chernobyl represent different source-terms and ecosystem characteristics. Advanced analytical techniques will be used to determine source-term characteristics, actinide transfer and bioavailability at the sites. These include state-of-the-art speciation methods and ultra low-level techniques for actinide levels and isotopic ratios measurements. A summary report and database directed at scientists, modellers and authorities will be provided.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Universal Banking, Corporate Control and Crises' in the context of a Seventh Framework call.

assistant: **Objectives**

Financial intermediaries play a vital role in providing capital to corporations. The 2007-2009 financial crisis had dramatic consequences on the organization of the financial system that led to the rise of universal banking and financial conglomerates. Financial conglomerates have been common in Europe, but the recent developments have eroded the separation of commercial and investment banking elsewhere. Financial conglomerates act as lenders but also underwrite and trade securities, have equity stakes and sit on the board of corporations, and manage mutual and pension funds that invest in corporations. These forms of corporate control by financial conglomerates are distinct in their incentives and costs and therefore can have distinct effects on non-financial corporations. We will study the effect of control by financial conglomerates on corporation’s performance, investment, financing, and corporate governance policies. A particular relevant channel through which financial conglomerates can affect firm’s policies is the credit channel. Firms establish relationships with financial conglomerates that give easier access to credit and potentially at a lower cost due to economies of scale in information collection and monitoring. There may be, however, costs to firms with a close relationship with a financial conglomerate as firms may be locked up due to an information monopoly. We will study the effects of bank-firm relationships on the loan market. In particular, we will examine the importance of these relationships for explaining differences in the cost of bank distress across firms. The hypothesis is that strong ties with banks reduce firms’ ability to substitute relationship bank loans with other sources of external finance, and therefore firms with stronger relations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordination Action for implementation and alignment activities of the Joint Programming Initiative (JPI) 'More Years – Better Lives – the Challenges and Opportunities of Demographic Change'' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

J-AGEII, the Coordination Action for implementation and alignment activities of the Joint Programming Initiative (JPI) 'More Years Better Lives – the Challenges and Opportunities of Demographic Change', will support and foster the overall management of the JPI, update the Strategic Research Agenda and support implementation through joint activities between Member States. Furthermore, the work plan will include dissemination and information exchange with scientific and societal stakeholders, policy makers and research funders as well as an evaluation and monitoring exercise. Ultimately, the project and the JPI seek to stimulate the alignment of relevant national programmes and EU initiatives, strengthen the base of multi-disciplinary and holistic ageing research in Europe and to provide scientific evidence for policy responses to demographic change.


**Keywords:** implementation, joint activities, alignment,demographic change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PRECISION MEDICINE PLATFORM IN NEURODEGENERATIVE DISEASE' to be submitted under Horizon Europe.

assistant: **Abstract**

Neurodegenerative diseases are one of the most important contributors to morbidity and mortality in the elderly. In Europe, over 14 million people are currently living with dementia, at a cost of over 400 billion EUR annually. Comorbidities with these conditions are frequent and a major obstacle to optimal diagnosis and management. Recent advances in diagnostic technologies and the advent of disease-modifying therapies (DMT) for Alzheimer’s disease (AD), the most common aetiology of dementia, heralds the beginning of precision medicine in this disease area. PROMINENT will develop a digital platform for precision medicine that will remove barriers that currently exists for leveraging these technological advancements in the routine care of patients with neurodegenerative disorders and co-morbidities. The platform gives clinicians access to prediction models leveraging multimodal diagnostic data automatically derived from multiple sources (imaging repositories, medical records, mobile devices), helping them choose optimal care pathways and improving diagnostic precision. It will provide personalized, relevant and meaningful information on diagnosis and prognosis in a format understandable by patients and care partners. Further, it will support the introduction of new health technologies such as DMT for AD, by ensuring adherence to appropriate use guidelines and facilitating the prospective collection of data on real-world usage, safety and effectiveness. The expected impact of the project is to increase diagnostic accuracy and optimized use of existing and new treatment options. It will empower patients and caregivers by engaging them in more person-centric health care decisions, leading to improved adherence and patient experience. Ultimately this is expected to lead to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Application of transfer operators to dynamical systems' in the context of a Fourth Framework call.

assistant: **Objectives**

Transfer operators appear in the examination of the geodesic flow of compact Riemannian manifolds of negative curvature and more generally axiom A-systems which model systems in both classical and quantum mechanics. Their spectral properties can be related to the analytical ones of Fredholm- determinates and S-functions which are defined by the unstable periodic orbits of the system. I am trying to study the theory of transfer operators, which is up to now understood the best for low dimensional systems, in the higher dimensional case.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Developement of robust and quantitative biosensors based on near-infrared two-dyed silicate nanoparticles'.

assistant: **Innovation**

The aim of this project is to develop quantitative biological sensors based on fluorescent spherical silicate nanoparticles (amorphous silica, zeolite beta) in controlled sizes in the range of 50 to 200 nanometers in diameter. The quantification of the analyte is based on a ratiometric detection of fluorescence from two dyes. The dyes are chosen such that the fluorescence of one dye is a function of an analyte (ion, biomolecule) concentration (sensing dye) whereas the fluorescence of the other dye is independent of variations in the medium (reference dye). Both dyes have the near-infrared light absorption property which lead to significant improvements for the detection in biological samples. The first step consists in confining a dye in the inorganic network yielding highly brilliant and photostable objects. Thus this fluorescent hybrid core can be used as the reference dye. Afterwards the ability of such material to undergo further chemical modification through the surface silanol functions and the use of coupling agents allows the immobilization of the sensing dye (commercially available or developed in the host structure). This is considered through various strategies e.g. direct immobilization or embedded polymeric shell.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MyGrid; Energy Efficient and Interoperable \nSmart Energy Systems for Local Communities' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

One promising answer leveraging the time frame of investment in changes of power supply and demand is to optimize the grid capacity with Smart Grids. However, a managed customer demand with intensive grid monitoring, automation and reliable customer flexibility is needed to allow for a real and secure reduction in residual capacity.The aim of GreenCom is to utilise the flexibility and intelligence in the low-voltage demand and local supply side infrastructure to create increased regulation capacity and reserve power in the centralised power grid by extending the means to effectively and securely manage demand and supply within defined boundaries. GreenCom thus aims to balance local exchange of energy at the community microgrid level (e.g. Smart Cities), to avoid destabilizing the centralized grid.GreenCom adopts a business model driven development approach, mapping dynamic value constellations to business cases capturing the service concept idea to consolidate user requirements and drive the user evaluation.The GreenCom Smart Energy System will collect, aggregate and analyse data from appliance level consumption such as appliances, smart home devices, sensors and actuators and smart meters. The data analysis will provide real-time consumption data on type of devices and location together with short term forecasts (up to 4 hours) aggregated over several sectors of the grid. A value based demand control based on individual consumer contracts with attractive tariffs, reward/penalty clauses and other elements will allow intelligent energy demand management and control including local energy generating and storage installations.GreenCom will allow energy distributors to start focussing on Energy System effectiveness. Energy suppliers will be able to shift from Smart Power Gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PlateLys: The innovative human platelet lysate especially designed to maximize the effectiveness of cell-based therapies' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cellular therapies making use of stem cells, engineered immune cells or engineered tissue represent an unprecedented and fast-growing therapeutic area. To date, 14 cell therapies have been approved by the FDA. However, the cells being implanted to the patient need to be cultured in vitro at some point under highly specific and controlled conditions. One of these conditions –indispensable to culture any type of isolated cell in vitro– involves using animal-derived serum as a source of hormones and growth factors to mimic cells' native environment. It is estimated 1.5 million calf fetuses are inhumanely sacrificed to collect serum. This leads (among other negatives) to endanger patient's safety, because of cross-species immune reactions (which may be lethal) and the transmission of animal borne diseases (e.g. the mad cow disease). PlateLys is PLATOME´s solution to develop and produce a remarkable human-based serum substitute fulfilling all the requirements to culture cells. PLATOME is an award-winning Icelandic start-up created in 2016 to leverage the substantial know-how on human platelet lysates (hPL) production from its founders. PlateLys is the only hPL combining: a viral-inactivated hPL ensuring the highest safety profile for patients and operators; a clinical-grade lysate with standardized quality control and GMP certified amenable for research and clinical set-ups; a powder formulation providing maximal flexibility, especially on applications that were nonviable previously. The market of sera supplements will be worth €1.14 billion by 2025 (CAGR of 8%, period 2017-2025) with a large shift to hPL use ongoing. Through the PlateLys project we seek to complete the optimization and scale-up production, starting commercialization activities in Europe by 2021. By 2025, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Continuous Variable Quantum Communications' in the context of a Horizon 2020 call.

assistant: **Objectives**

The goal of the CiViQ project is to open a radically novel avenue towards flexible and cost-effective integration of quantum communication technologies, and in particular Continuous-Variable QKD, into emerging optical telecommunication networks.CiViQ aims at a broad technological impact based on a systematic analysis of telecom-defined user-requirements. To this end CiViQ unites for the first time a broad interdisciplinary community of 21 partners with unique breadth of experience, involving major telecoms, integrators and developers of QKD. The work targets advancing both the QKD technology itself and the emerging “software network” approach to lay the foundations of future seamless integration of both. The technological advantage will more specifically aim to:- Design architectures and implement protocol extensions of flexible “software based” networks for midterm country-wide QKD reach.- Drive CV-QKD systems and components up to TRL 6, derive standardized set of interfaces, also allowing a network-aware software defined functionality and open modular development, and pursue cost reduction by seamless integration of off-the-shelf components.- Push CV-QKD performance boundary forward by developing high-performance photonic integrated circuits (PIC) for CV-QKD, i.e. opening the way for ultra-low cost systems, and improve further the CV-QKD hallmark coexistence capability with standard WDM channels, i.e. reducing dramatically the barriers to optical network co-integration.- Prepare actively for next-generation networks by developing core enabling technologies and protocols aiming at quantum communication over global distances with minimal trust assumptions.CiViQ will culminate in a validation in true telecom network environment. Project-specific network integration and s