RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sex, disPlacements, And cross-Cultural EncounterS' in the context of a Horizon 2020 call.

assistant: **Objectives**

While for a long time historians of ideas have highlighted the seventeenth- and eighteenth-century Northern European liberal genesis of the idea of tolerance, recent historical research has indeed revealed its medieval and early modern gestation across the Mediterranean area. SPACES aims to originally investigate these attitudes by analyzing the links between two apparently disjointed aspects: religious and sexual toleration in the early modern Mediterranean world. Thanks to a survey of the sources I have already carried out in the archives of the Spanish and Roman Inquisition, I have uncovered a not yet investigated 'heresy' that circulated in the Italian peninsula between the 16th and 18th centuries. The defendants thought that Adam and Eve practiced anal sex in the terrestrial paradise, praising the pleasures of unreproductive sexuality. They also stated that ‘all can be saved in their own law’, that is, that the eternal salvation was not limited to any specific religious or cultural tradition. These heretical ideas were partially influenced by Islamic beliefs, although through the meditation of Christian anti-Islamic writings. Some of the defendants were also charged with apostasy to Islam. These facts further prove the influence of Islamic thought on religious heterodoxy in early modern Europe. I aim to prove that, in these cases, questioning the religious prescriptions regulating sexual morality prepared the ground for a wider critique of the political and social order, stimulating more inclusive understandings of religious identities. Uncovering a past in which toleration was practiced and theorized despite an ongoing religious war contrasts the simplified interpretation of today interactions with Islam in the public discourse in terms of a 'Clash of Civilization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational modelling for personalised treatment of congenital craniofacial abnormalities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Craniosynostosis is a group of congenital craniofacial abnormalities consisting in premature fusion (ossification) of one or more cranial sutures during infancy. This results in growth restriction perpendicular to the axis of the suture and promotes growth parallel to it, causing physical deformation of the cranial and facial skeleton, as well as distortion of the underling brain, with potential detrimental effects on its function: visual loss, sleep apnoea, feeding and breathing difficulties, and neurodevelopment delay. Conventional management of craniosynostosis involves craniofacial surgery delivered by excision of the prematurely fused sutures, multiple bone cuts and remodelling of the skull deformities, with the primary goal of improving patient function, while normalising their appearance. Cranial vault remodelling surgical procedures, aided by internal and external devices, have proven functionally and aesthetically effective in correcting skull deformities, but final results remain unpredictable and often suboptimal because of an incomplete understanding of the biomechanical interaction between the device and the skull.The overall aim of this grant is to create a validated and robust computational framework that integrates patient information and device design to deliver personalised care in paediatric craniofacial surgery in order to improve clinical outcomes. A virtual model of the infant skull with craniosynostosis, including viscoelastic properties and mechano-biology regulation, will be developed to simulate device implantation and performance over time, and will be validated using clinical data from patient populations treated with current devices. Bespoke new devices will be designed allowing for pre-programmed 3D shapes to be delivered with continuous fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Development of novel integrated sequencing methods to explore translation and its regulatory mechanisms in single cells'.

assistant: **Concept**

In recent years novel single-cell sequencing methods have allowed an in-depth analysis of the diversity of cell types and states in a wide range of organisms. Due to the continuous optimization of experimental and computational methods by many research groups, it is now possible to sequence the transcriptomes of thousands to millions of individual cells. Albeit an exciting development, transcription only covers the first step in the central dogma. The second step, the process of translation, is currently much harder to explore in single cells. Building upon existing ribosome profiling protocols, our laboratory recently majorly increased the sensitivity of these assays allowing ribosome profiling in single cells. However, currently no methods exist to determine the translation efficiencies in single cells and to correlate translation efficiencies to tRNA levels and their modifications, RNA bound proteins, and m6A methylation of mRNA, all major regulatory mechanisms of translation. The overarching goal of this proposal is to develop several novel multi-omics approaches to quantify translation in single cells by integrating information on ribosome position along the transcript, tRNA expression levels, tRNA modifications, RNA-bound proteins, and the m6A methylation status of the transcript. These technologies will open novel avenues to start exploring translation and its regulatory mechanisms with single-cell resolution. Whereas major discoveries have been made during the last decade by exploring the genome, the epigenome, and the transcriptome using single-cell sequencing approaches, translation, the major second step in the central dogma, is still very much unexplored at the single-cell level. I hope that the tools, presented in this proposal will provide the community wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fast and efficient sponge engines drive and modulate the food web of reef ecosystems' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Coral reefs are iconic examples of biological hotspots, highly appreciated because of their ecosystem services. Yet, they are threatened by human impact and climate change, highlighting the need to develop tools and strategies to curtail changes in these ecosystems. Remarkably, ever since Darwin’s descriptions of coral reefs, it has been a mystery how one of Earth’s most productive and diverse ecosystems thrives in oligotrophic seas, as an oasis in a marine desert. My team recently discovered the ‘sponge loop’ pathway (Science, De Goeij et al 2013) that efficiently retains and transfers energy and nutrients on the reef. We recognized sponges as potential (and so far neglected) key ecosystem drivers, and accumulated evidence on sponge loops in other ecosystems, such as deep-sea coral reefs. As a result, current reef food web models, lacking sponge-driven resource cycling, are incomplete and need to be redeveloped. However, mechanisms that determine the capacity of sponge 'engines', how they are fuelled, and drive communities are unknown.     This proposal will systematically establish the novel reef food web framework, integrating sponges as key ecosystem drivers. To this end, sponges will be evaluated on functional traits (morphology, associated microbes, pumping rate) in the processing of dissolved food, the main fuel of the engine. At the community level, we will assess to what extent these different traits are a driving force in structuring reef ecosystems, from fuel input (primary producers), to engine output (driving and modulating the consumer food web). This framework derived from a Caribbean reef ecosystem will be implemented in a sponge-driven food web model, a much-needed foundation to test and predict future scenarios of changes in reef communities. Ultimatel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lectibodies to Eliminate Tumours' (Lectibodies) targeting Horizon Europe.

assistant: **Abstract**

Antibody-mediated delivery of therapeutic compounds to tumor cells for the treatment of cancer is a rapidly growing multibillion-euro market. One class of tumor markers, the glycosphingolipids (GSLs), are only rarely addressed in this context, due to the difficulty of obtaining antibodies against them. In this proof-of-concept program, we will develop a novel class of products  lectibodies  for the delivery of therapeutic compounds to tumor-specific GSLs. Our lectibodies are based on a naturally occurring GSL-binding protein with intrinsic tumor targeting capacity. We will rely on a proprietary phage library technology to isolate lectibodies against GSLs (or cocktails thereof). In this PoC program we will optimize and apply our technology to specifically target O-acetyl GD2, a GSL highly expressed in neuroblastoma tissues.  This will enable us to generate lectibody-based therapeutics against neuroblastoma in children, a devastating disease for which the drug market is predicted to reach 118 million in 2022. We will explore two options for further business development: a) building off of our current partnership with OGD2 Pharma (a biotech based n Nantes, France) and b)creation of a spin-off company which will license deals to several pharmaceutical partners based on pathology. We will capitalize on the expertise in launching start-ups of our principle investigator and on close links with clinicians and industry partners. Our technology has truly groundbreaking potential as, in principle,  chimeric lectibodies can be developed against virtually any tumor-specific cocktail of GSLs thus opening the door for the development of novel therapies for several cancers. Thus, following the development of neuroblastoma-specific lectibodies,  we foresee a wider range of future applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrating the ecological and evolutionary consequences of phenological change in a wild mammal system', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In recent years an increasing number of studies have documented phenological responses to climate change in wild animals. However, while most studies have focussed on individual life history traits we know that natural selection acts on whole phenotypes and organismal impacts of environmental change are mediated by complex causal pathways among traits . Thus to understand the evolutionary and ecological consequences of environmental change we need multivariate modelling strategies that integrate across life-history, morphology, behaviour and physiology. This integration is essential to understand population level processes, and without it demographic predictions for wildlife management and conservation objectives will be flawed. The primary goal of the proposed research is to develop and apply such an integrative approach, quantifying the relationship between multivariate phenotypic selection and environmental parameters (e.g. spring temperature), and determining the consequences of environmental change for trait distributions, life history trade-offs and population dynamics. Using an exceptional long term dataset that spans more than 50 years of research on wild yellow bellied marmots, I will employ cutting-edge analytical methods to identify causal relationships among traits, decompose them into genetic and environmental components, and quantify their contributions to (genetic) variance in fitness. The project will be carried out in the group of Dr. Wilson (CEC, University of Exeter), where I will receive a thorough training in evolutionary quantitative genetics from one of the global leaders in this field. At the same time I will also bring new analytical skills and knowledge that directly benefit his research program, other scientists at the University of Exeter, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bringing Organisations and Network Development to higher levels in the farming sector in Europe' (BOND) under Horizon 2020.

assistant: **Objectives**

BOND acknowledges the fundamental role farmers and land managers play in the environmental and economic sustainability of the farming sector in Europe, as well as the importance of the way they organise, on Europe’s foods and landscapes. BOND contributes to unleash, strengthen, and organise, the great potential for collective action and networking of individuals, groups and entities of farmers and land managers, focusing on countries with lower organisation levels, with a view to creating strong, dynamic and effective organizations that have a voice and a place in policy design. More specifically, BOND investigates and addresses the constraints and disincentives, and reaches a higher level of participation of farmers as follows: (i) Draw up solutions and build bonding capital within groups, ensuring cohesiveness and trust among people; (ii) Enable organizations to come closer, building bridging capital to form larger networks, help overcome attitudes and constraints that impede collective action; (iii) Build linking capital, developing ties with entities with different interests and powers, including government, donors, academia, private sector, to reach a stronger position in decision-making, and (iv) Engage multi actors and policy makers throughout these processes. BOND’s approach relies on 3 pillars: SEE-learning from success (mobilisation, study tours), LEARN-overcoming constraints (self-analysis, capacity building), TELL-affirming a position in the policy landscape (gaming interface, best practice in regulation, lab experiment), and on involving the youth, women and men (designing a road map for the future), with training sessions and meeting events at every step of the project (interregional forum, national workshops, regional policy roundtables, youth forum). BON
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Personalized Adjuvant Treatment for HR+/HER2- breast cancer FOR YOUNG patients' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Worldwide, ~7 million women live with or beyond Breast Cancer (BC), as 10-year survival rates exceeding 80% for early-stage (I-III) BC. Premenopausal BC accounts for 25% in the EU and 55% in low/middle income countries. Most premenopausal women with BC have high risk of recurrence, therefore standard treatment includes adjuvant chemo- (CT) and endocrine therapy (ET). However, treatment has substantial physical, emotional and social burden, which is often more pressing for younger compared to older patients.Gene-expression assays are  used for post-menopausal patients to identify women who can safely forego CT without detriment on clinical outcomes, preserving Quality of Life (QOL). However, a definitive study has yet to be conducted among premenopausal women with high-risk HR+HER2-BC. The primary objective of PATH-FOR-YOUNG is to conduct a pragmatic randomized controlled trial (RCT) with 5000 patients validating the use of a gene-expression assay to drive adjuvant treatment decisions in this target population.PATH-FOR-YOUNG aims to achieve its objective in 7 years. The project (i) builds on and complements an ongoing twin RCT to ensure timely recruitment, (ii) leverages on a large international consortium of oncologists, pathologists, patient representatives, psychologists, sociologists, ethics and communication experts, biostatisticians, health economists, and technology providers, to assure complementary and multidisciplinary expertise, and (iii) highlights patient-engagement, participatory care, and early involvement of end users. PATH-FOR-YOUNG will also study implementation of digital self-management to support patients throughout the cancer journey and particularly while on ET to improve QOL and medication adherence. A full HTA will ensure a path towards cross-cou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'IMPROVEMENT OF PRE- AND END-HAULAGE'.

assistant: **Innovation**

The main objective of IMPREND is the improvement of pre- and end-haulage at terminals, achieved by defining and testing a number of formulas on how to improve pre- and end-haulage. The project consists of four phases. In the first, the present situation with regard to pre- and end-haulage will be analysed. In the second, a number of formulas on how to improve pre- and end-haulage will be defined and discussed in meetings with (potential) users of Intermodal Transport. These formulas will be tested at a selected number of terminals. After identification of the most successful formulas, they will be made applicable for implementation at terminals throughout Europe.The deliverables are the following:1 a report with an overview of the intermodal structures (terminals, players, routes) in the corridors between the terminals involved; an overview of present methods of working with regard to pre- and end-haulage at the selected terminals; and a listing of the most important bottlenecks in pre- and end-haulage at the terminals studied as well as examples of solutions in Europe and the USA. 2 an overview of formulas for the improvement of pre- and end-haulage and of the outcomes of the various users meetings organised in participating terminal regions. 3 a report on the results of the demonstration projects.4 the final report, including recommendations for transport companies, for terminal operators and for other organisations in the field of intermodal transport. It will also highlight implications for future government policy as well as recommendations for policy makers (both at a national and EU level).Specific intermodal objectives:IMPREND aims at enhancing the efficiency of terminals as an integral part in the intermodal transport chain.Links with other projects, tasks, are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigate the mode of action ofInvestigate the mode of action of beta-carboline derivative Harmine on increasing MHC-I expression and potentiating the Immune Checkpoint Blockade cancer immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

One of the major mechanisms by which solid tumors escape anti-tumor immunity is the downregulation of major histocompatibility complex class I (MHC-I), which causes a failure in the recognition of tumor cells by the cytotoxicity T-cells. The project proposed by Dr. Teresa Ramos contains basic and translational aspects. The basic aspect relies on investigating the mechanisms of action of the ACB1801 molecule (harmine), reported by the host team to restore the MHC-I in tumor cells, using state-of-the-art technologies. The translational aspect of the project relies on providing the preclinical proof of concept for an innovative immunotherapy combination. The combination strategy consists of using a vaccination approach with Dendritic Cells (DC), pulsed with tumor cells pre-treated with ACB1801, in combination with immune checkpoint blockades. Although DC vaccination constitutes potent anticancer immunotherapy, clinical data showed that it does not provide robust benefits to patients. the innovative strategy of the project is based on simultaneous boosting the DC-based vaccine by ACB1801 and unleashing the power of T cells to induce a robust anti-tumor immune response which constitutes an unmet clinical need. The development of the present proposal will enable Dr. Ramos to achieve a broad range of new technologies and management skills through a variety of multidisciplinary training programs. This will represent a key step toward her final objective to become an independent and competitive scientist.


**Keywords:** β‐carboline Harmine, ACB1801, MHC-I, Dendritic Vaccine, Immune Checkpoint Blockade, PD-1, melanoma, colon carcinoma