RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart multifunctional GLA-nanoformulation for Fabry disease' (Smart-4-Fabry) under Horizon 2020.

assistant: **Objectives**

Lysosomal storage disorders (LSD) diseases are a group of rare diseases that currently lack a definitive cure. LSD incidence is about 1:5,000 - 1:10,000, representing a serious global health problem. In the case of Fabry LSD Disease (FD), the deficiency in α-Galactosidase A (GLA) enzyme activity results in the cellular accumulation of neutral glycosphingolipids, leading to widespread vasculopathy with particular detriment to the kidneys, heart and nervous system.  The current treatment for FD is the Enzyme Replacement Therapy (ERT), in which free GLA recombinant protein is administered intravenously to patients. ERT exhibits several drawbacks mainly related to the instability, high immunogenicity and low efficacy of the exogenously administered GLA to cross biological barriers, such as cell membranes and BBB.The aim of Samrt-4-Fabry project is to achieve excellent quality control over the assembly of the different molecular components of a new liposomal nanoformulation of GLA, nano-GLA, for the treatment of Fabry disease. Nanoformulated GLA has already shown to have better PK/PD profile than free GLA and higher efficacy in vivo.  Smart-4-Fabry project will advance nano-GLA from an experimental PoC (TRL3) to preclinical regulatory phase (TRL5-6). A one-step method based on the use of green cCO2, will be used for the manufacturing of this novel nanoformulation under GMPs. The final GLA nanoformulation will have tailored transport of GLA through cell membranes and BBB. Fulfillment of Smart-4-Fabry will impact on a major health problem, the existence of new therapies for rare diseases, which constitutes a priority societal challenge as shown in the H2020 Work Programmes. Another important impact is related to its contribution to support the European Strategy for KETs, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wireless and wireline service convergence in next generation optical access networks' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The next generation of information technology demands both high capacity and mobility for applications such as high speed wireless access capable of supporting broadband services. The transport of wireless and wireline signals is converging into a common telecommunication infrastructure. In this project, we focus on the conception and study of novel architectures for wavelength-division-multiplexing (WDM) optical multi-modulation format radio-over-fiber (RoF) systems, which is a promising solution to implement broadband seamless wireless-wireline access networks. One important feature of our proposed approach is versatile optical multi-modulation format radio-over-fiber systems with robust transmission, high spectral efficiency and high dynamic range properties, not achievable by conventional intensity modulated systems alone. We focus as well on conceiving access nodes designs that support converged wireless and wireline service delivery with energy efficiency and efficient use of a common optical fibre access infrastructure. To the best of our knowledge, no comprehensive theoretical and/or experimental study of the performance of these WDM RoF systems has been reported yet. Moreover, the stringent requirements of future communications links in terms of capacity, flexibility and multi-service support, motivate us to undertake a concise assessment of the ultimate achievable performance of wireline/wireless converged systems. The goal of this project is to theoretically and experimentally investigate the performance of multichannel, multi-modulation formats radio-over-fiber optical links for the transmission of wireless and wireline signals. The timely generated knowledge in this project will contribute to extend the state-of-the-art and to enhance European research exce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'THAWing permafrost: the fate of Soil Organic Matter in the aquatic Environment'.

assistant: **Innovation**

As the Arctic permafrost region warms, its large organic carbon (OC) pool becomes vulnerable to decomposition. This generates greenhouse gases (GHG) that in turn fuel increased surface warming: the permafrost carbon feedback. Higher temperatures will jump-start the coupling between the carbon and hydrological cycle, allowing for the introduction of previously frozen OC pools in aquatic systems. This lateral, or horizontal, aquatic flux remains largely unknown in contrast to the relatively well-studied vertical flux, GHG emission on land. Horizontal OC release either occurs via gradual thaw, slowly leaching OC into aquatic systems, or abrupt thaw, where ground-ice melt causes destructive surface collapse and slumping of OC into aquatic systems. Both types of thaw facilitate decomposition of OC (generating GHG) but also re-bury OC into sediments (sequestering OC). The relative importance of decomposition versus burial is unknown. For THAWSOME, I have developed a multi-scale approach combining detailed process-based field studies with up-scaling techniques on multiple levels: (i) observational, using large Arctic rivers as natural integrators, (ii) numerical, using a coupled hydrological-biogeochemical model, and (iii) spatial, using GIS-based analysis. For the first time, decomposition of particulate OC from permafrost will be quantified with a recently developed incubation method. Burial rates of permafrost OC will be assessed through molecular isotope analyses of both sources (river OC) and sinks (sediment OC) across the land-to-shelf route. THAWSOME will generate critically needed quantitative data on the amount of decomposition versus burial of permafrost OC, as well as qualitative insights into the processes that control this. This will allow a true coupling of the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Discovery 08, the third trendy Discovery night, brimming with young scientists, new science, top DJs,  innovative cocktails and young opinion leaders. An Amsterdam event with broad national appeal' (2007-2013).

assistant: **Concept**

Amsterdam, Friday September 26, 2008. Fifteen hundred young scientists, creative minds and other young trend setters from Amsterdam and the rest of Holland are having a great time at Discovery 08, a good party with food for thought. From 8 pm to 3 am they enjoy a lot of new music, fascinating science, the latest technologies and ideas of visionary members of their own generation. There will be talking, drinking and dancing. Watching ultra short talks by inspiring scientists or tv personalities, enjoying top artists, DJ's and VJ's, playing experimental games from media scientists, joining in live scientific experiments –and much more. And if you want to share your thoughts or hear  more, a lot of Very Disco scientists will be around, having conversations about anything you may possibly think of.  Discovery 08 is a nighttime event, organised by a small professional foundation and a large group of young scientists. It is organised to improve the image of scientists by showing young, contagiously enthusiastic scientists to the public, and to prove that cool science can be Friday night fun just as well as cool art, new music and nice people.  Discovery 08 is the next step after the very first Discovery 06 in 2006 and the EC funded and hugely successful Discovery 07 of last year. In 2008, the organisation will be further professionalised, the press campaign will be refocused, professionalised and intensified and structural continuity for future years will be secured.  Previous events were sponsored by, next to the European Commission, the Dutch Organisation for Scientific Research, the Platform Bèta Techniek, the Royal Dutch Academy of Arts and Sciences, Shell, IBM, Dell a.o. This year, sponsor talks are in progress and the National Centre for Science and Technology has alrea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The socio-economic performance of social enterprises in the field of integration by work' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The role and potential of the social economy, in particular the work integration social enterprise, as an active labour market approaches to combating unemployment and creating employment has received increasing attention by policy makers. An innovative organisational form that incorporates an entrepreneurial dynamic alongside social objectives, preliminary research has examined the existence, services provided and characteristics of these social enterprises. Key questions have emerged concerning the beneficiaries of work integration social enterprises given their multi-stakeholder nature, their specific resource mix and their sustainability due to their evolution in organisational form. The PERSE project brings together leading academics in the social economy field to conduct an empirical and theoretical analysis of these key questions in respect of work integration social enterprises.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EuroLab-4-HPC: Foundations of a European Research Center of Excellence in High Performance Computing Systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Europe has built momentum in becoming a leader in large parts of the HPC ecosystem. It hasbrought together technical and business stakeholders from application developers via system softwareto exascale systems. Despite such gains, excellence in high performance computing systems is oftenfragmented and opportunities for synergy missed.To compete internationally, Europe must bring together the best research groups to tackle the longtermchallenges for HPC. These typically cut across layers, e.g., performance, energy efficiency anddependability, so excellence in research must target all the layers in the system stack. The EuroLab-4-HPC project's bold overall goal is to build connected and sustainable leadership in high-performancecomputing systems by bringing together the different and leading performance orientated communitiesin Europe, working across all layers of the system stack and, at the same time, fuelling new industriesin HPC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Doctoral Training Network in Terahertz Technologies for Imaging, Radar and Communication Applications' (TeraApps) under Horizon 2020.

assistant: **Objectives**

Our future world will be one of ubiquitous sensor systems - a “Real World Web” where billions of devices, machines, or “things” will connect to the internet. In 2008, more machines were connected to the internet than there are humans on the planet, and by 2020 there are predicted to be 50 billion machines connected to the internet. As a consequence, there will be an ever-increasing hunger for communications bandwidth, both at a local level within an office or apartment, and at nodes within data centres and server farms. The terahertz (THz) band is yet to be exploited, and occupies frequencies from 0.3 to 3 GHz (1mm to 100um) occupying a middle ground between microwaves and infrared light. THz technologies are also set to revolutionize a range of imaging, sensing, and quantum optics applications.Recently, tunneling devices have been shown to be the leading candidate in realizing compact, low cost, high performance THz transmitters and receivers once coupled to suitable antennas. Also, new two dimensional (2D) materials such as graphene or 1D nanowires are emerging as suitable platforms for realising highly sensitive detectors of THz radiation.  These emerging research areas link e.g. semiconductor materials synthesis, high speed electronic device physics and engineering, antenna design, THz optics, and a raft of diverse applications. A new generation of academic and industry leaders in developing these devices and systems in the terahertz spectral band is now required. However, the research community is dispersed, and this highly multi-disciplinary field requires specialist training.This network addresses this future societal need by addressing this training gap, and crystallising world leading groups in a concentrated research effort. A specialist training plan, includi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VELLO BIKE+ Connected Multimodal Commuting for Greener Cities' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

VELLO has designed the world’s first self-charging folding e-bike, VELLO BIKE+. We want to take this product, VELLO BIKE+, from beta product and production to full-scale production for a successful EU-wide roll. We do this by maximising social impact from production to user, and exploiting a 296 MM€ (by 2024) business opportunity. Thus, we are convinced that with this novel e-bike, we can provide additional choices for individual e-mobility with high benefits, bringing more people on bikes, raising the field of application for e-bikes, and at the same time filling important gaps in terms of multimodal mobility. VELLO is an Austrian-based R&D hub and manufacturer of innovative mobility products established in 2017. We have successfully developed a series of innovative solutions in the field of mobility.It is estimated that 95% of the world’s population is breathing dirty air, which contributes to severe diseases to the lungs and heart. Cities are the biggest contributors. While accounting for only 3% of the earth’s surface, they generate 75% of all carbon emissions. There is a need for decarbonised cities and a wide range of greener micro-mobility products providing city dwellers with more and better choices. Less fossil-fuel driven cars means a reduction in CO2 emission rates. Folding e-bikes are one of the solutions, but existing ones are heavy, complicated to fold, feel unstable when riding and do not recuperate energy.  Moreover, no other existing folding e-bike enables IoT connectivity that would allow the development of new business models and offerings. We have developed the first self-charging folding e-bike that runs on kinetic energy recovery system (K.E.R.S.) with super-efficient energy regeneration and real-time environmental sensing and connectivity capabili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Thresholds in past relative Humidity and Ecosystem Structure in Africa' (THrESholds) under Horizon 2020.

assistant: **Objectives**

Tropical forest and savanna are home to one-fifth of global human population. With ongoing global change, predicting how these biomes will respond to changing rainfall and relative humidity (RH) is of high priority. The overall aim of this project is to identify thresholds in RH that triggered in the past (last 10,000 years) the transition from forest to savanna and those that made forest resilience possible in Africa. I will use a new RH proxy, recently developed by the host laboratory, which is the triple oxygen isotope composition (17O-excess) of phytoliths. While calibrations were conducted in growth chambers, field applications are needed to precisely evaluate the accuracy of the proxy. I will examine the evolution of the 17O-excess in the water cycle and in grass and tree phytoliths, and quantify the isotopic fractionation at play, at a West African instrumented site. Then 17O-excess bias potentially brought by the contribution of phytoliths from lake shoreline vegetation to bulk sedimentary phytoliths will be quantified. Finally, I will analyse the 17O-excess of phytoliths from four West and Central African Holocene lacustrine sedimentary cores to reconstruct changes in RH. Vegetation structure and fire activity will be reconstructed from the same sediments. The effect of reconstructed RH and fire activity trends will be analyzed using time series cross-correlation and spectral analyses, and thresholds in RH identified using regime shifts analyses. These results will help to better understand the impacts of past climate change on tropical forest resilience. During this project, I will acquire new laboratory skills, develop the use of a new paleoclimate proxy, reinforce my scientific leadership and expand my career prospects in academia. I will bring my expertise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MultiphasIc NanoreaCtors for HEterogeneous CataLysis via SmArt ENGinEering of TaiLored DispersiOns' to be submitted under Horizon 2020.

assistant: **Abstract**

Gas-liquid-solid (G/L/S) multiphasic reactors are extensively used in the chemical industry for catalytic processes. However, conventional reactors, such as packed beds and slurry reactors, typically suffer from resilient mass/heat transfer limitations due to their low specific interface areas, long mixing times, and a reduced accessibility of the gas reactants to the catalyst surface. To overcome these limitations, continuous flow microreactors and catalytic membrane reactors have been considered for increasing the G/L interface area, but these systems require complex equipment and still do not guarantee an efficient L/S contact at the catalyst surface. For a major improvement on current systems in terms of cost efficiency and energy savings, G/L/S reactors operating at the nanoscale are required.The aim of this ERC project is to design robust particle-stabilized G/L dispersions (i.e. micro/nano-bubbles and liquid marbles) as highly efficient G/L/S nanoreactors for conducting catalytic reactions at mild conditions.We will (i) prepare NPs with defined sizes, shapes, hydrophilic-lipophilic balance (HLB), including catalytic functions; (ii) generate particle-stabilized bubbles and liquid marbles affording highly active and selective reactions at the G/L/S interface with NP recycling after each catalytic cycle using external stimuli; examine the interplay between the NP assembly at the G/L interface and the catalytic properties along the reaction by combining well-designed experiments with simulations; and (iv) reengineer G/L/S multiphasic reactors using our particle-stabilized nanoreactors to achieve a high catalytic performance at milder operation conditions compared to conventional reactors while keeping a high degree of stability and flexibility at reduced layouts.Thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'N-level correlations in the spectrum of a laplacian' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The aim of the project is to prove - or at least give some heuristics - for the truth of the Bohigas - Giannoni - Schmit conjective for the eigenvalues of the Laplacian of a surface of variable negative curvature. Training content (objective, benefit and expected impact) Take advantage of the presence of mathematicians and physicists to be exposed to methods of both disciplins. The interest of Alain Connes in the Riemann hypothesis is another attractions.