RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sea Change' (SeaChange).

assistant: **Concept**

The overarching goals of the Sea Change project are to bring about a fundamental “Sea Change” in the way European citizens view their relationship with the sea, by empowering them – as ‘Ocean Literate’ citizens - to take direct and sustainable action towards healthy seas and ocean, healthy communities and ultimately - a healthy planet.Key objectives of Sea Change are to:• Compile an in-depth review of the links between Seas and Ocean and Human health based on latest research knowledge outputs• Build upon the latest social research on citizen and stakeholder attitudes, perceptions and values to help design and implement successful mobilisation activities focused on education, community, governance actors and directly targeted at citizens. marine education• Build upon significant work to date, adopting best practice and embedding Ocean Literacy across established strategic initiatives and networks in order to help maximise impact and ensure sustainability• Ensure that efforts to sustain an Ocean Literate society in Europe continue beyond the life of Sea Change through codes of good practice, public campaigns and other ongoing community activities.• Ensure that all activities of Sea Change are carefully monitored and evaluated to ensure maximum sustainability, effectiveness and efficiency• Ensure Knowledge exchange with transatlantic partners to bring about a global approach to protecting the planet’s shared seas and ocean.The objectives will be achieved by a closely interlinked programme.  Sea Change includes a mobilisation phase engaging with citizens, formal education and policy actors.  Crucially the legacy of Sea Change, including  continuing knowledge sharing with North America, are embedded within the project.


**Keywords:** Seas and Ocean Health, behavioural chang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DESIGN AND EVALUATION OF INNOVATIVE SOCIAL INSURANCE POLICIES' to be submitted under Seventh Framework.

assistant: **Abstract**

The following proposal aims at the design and evaluation of innovative social insurance policies (DEISIP) as alternatives to current policies applied by governments in industrialized countries. The study of Social Insurance (SI) policies is motivated by the high and rapidly increasing total expenditure on SI policies in OECD countries. These expenditures have increased on average across OECD countries from 16% of GDP in 1980 to 21% in 2003 (OECD, 2007). Given these statistics, governments throughout the world are keen on either finding alternative policies to the existing ones or increasing the efficiency of current policies.In order to address these issues the study will use Dynamic Stochastic General Equilibrium (DSGE) models with heterogeneous agents. This type of models is becoming extremely influential in macroeconomic for studies of economies that involve dynamics, uncertainty and policy design.This proposal is composed of three sub-projects, each dealing with at least one SI policy. The unifying theme of all projects is the analysis of creative policies that have strong relevancy for economic outcomes through in-depth welfare examination. The first sub-project is Unemployment insurance over the business cycle.In this sub-project, I will study state-dependent policies towards unemployed workers, i.e., I will allow the characteristics of the UI policy, such as the duration and the level of payments, to change over the business cycle in an optimal way.The Second sub-project is Integration of social insurance policies.In this sub-project, I will examine the potential for a welfare gain by integrating several SI policies, i.e. allow households to use funds saved in a specific account for a variety of purposes such as out-of-pocket health expenditures, and housing. Sin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Accelerating the Path Towards Physical Internet' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Results from a simulation experiment with top retailers Carrefour and Casino in France and their 100 top suppliers moving from actual practice to a “Physical Internet Model” showed a potential economic benefit of 32%, a 60% reduction of greenhouse gas emissions and a potential of 50% of volume shifted from road to rail. Accelerating the Path Towards Physical Internet -SENSE-  project strategic objective is to accelerate the path towards the Physical Internet (PI), so advanced pilot implementations of the PI concept are well functioning and extended in industry practice by 2030, and hence contributing to at least 30 % reduction in congestion, emissions and energy consumption.To that end, SENSE aims to increase the level of understanding of PI concept and the opportunities that brings to transport and logistics. By building stronger and wider support of industry, public bodies and research worlds towards the PI we may reach consensus and enable coordinated strategic public and private investments in research and innovation embracing Physical Internet that could lead us to a new much more efficient and sustainable paradigm.SENSE will: 1) enhance, and stabilize a solid framework for industry, research and public bodies to share advances, barriers, opportunities and best practices regarding Physical Internet implementation, 2) build awareness and raise wide consensus on the Detailed Roadmap towards the Physical Internet developed in the frame of the project, 3) Create The Reference Knowledge Platform so the Physical Internet Community has access to recent developments including: PI implementation cases assessment, industry programs and activities, related start-ups, research and innovation projects, public initiatives and programs and last, but not least, 4) assist and suppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of the first fully biocompatible, soft actuated heart: combining in situ tissue engineering and soft robotics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Hybrid Heart consortium envisions to develop and bring to the clinic soft biocompatible artificial organs. These will consist of a soft robotics shell with actuators (‘artificial muscles’) and sensors, enabling completely natural motion. The inner lining and structures will be made by in situ tissue engineering (TE), ensuring biocompatibility of blood-contacting surfaces.As the first step, the consortium will develop the Hybrid Heart, which can completely replace a patient’s heart in a procedure similar to a heart transplant, to provide a cure for heart failure, which affects ~23 million people worldwide. Currently, patients with end-stage heart failure either receive a heart transplant, if available, or long-term mechanical circulatory support, which causes severe complications. To achieve the ambitious goal of providing a permanent cure for these patients, the participants will, in parallel, develop the components of the Hybrid Heart: 1) a soft elastomeric robotics shell containing actuators and sensors, 2) scaffolds for in situ TE of inner lining, valves and vessels and 3) a wireless energy transfer system. These components together will form the full Hybrid Heart, which will be soft, adaptable, wireless and fully bio- and hemocompatible. Both functionality as well as biocompatibility of the Hybrid Heart will be shown in a Proof-of-Principle study in the chronic sheep model at the end of the project.The Hybrid Heart project will be carried out by an interdisciplinary group of (academic) researchers and high-tech SMEs, with experience in cardiac surgery, TE, soft robotics and engineering. The technology underlying the Hybrid Heart is applicable to a range of soft robotics-based artificial organs, including the bowel, lung, or muscle structures (limbs). Replacing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The first-in-class disease-modifying drug for chronic airway disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

EpiEndo Pharmaceuticals is a drug development company focused on developing novel drugs that target epithelial differentiation and enhance regeneration and barrier function. In contrast to the prevailing anti-inflammatory approach to respiratory drug discovery, EpiEndo has come up with a novel paradigm-changing platform to develop drug candidates that alter (respiratory) epithelial stem cell differentiation and enhance epithelial regeneration of the airway epithelium.By rational design we have discovered and developed Bronchothelin, is the first-in-class disease-modifying treatment for Chronic Obstructive Pulmonary Disease (COPD), a non-antibacterial macrolide with excellent safety and efficacy profile, poised to provide 50% reduction of COPD hospitalisations and preventing COPD-related mortality, without inducing antimicrobial resistance associated with the use of macrolide antibiotics. COPD is a progressive and currently incurable lung and airway disease affecting >250M patients annually, causing >3.17M deaths globally. Current therapies include inhaled bronchodilators or anti-inflammatory corticosteroids that provide symptomatic relief but fail to slow down the progression of the disease or reduce associated mortality. 22M COPD patients are being treated globally and the COPD drug market is predicted to grow from >€13B to >€18B in 2026. Even when capturing a conservative 3.5% market share, Bronchothelin has a blockbuster potential with >€4.9B sales in EU and US combined, predicted 5 yrs after market introduction (2027). Bronchothelin is now ready to enter FIH study. After completing the Ph2 clinical trial, we aim to commercialize through a licensing deal (2023) with a pharma company for further clinical development (Ph3) and sales, generating an estimated €150-€230 m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extending plant life through improved fabrication and advanced repair methodology' to be submitted under Fifth Framework.

assistant: **Abstract**

AIM: To eliminate the need to conduct costly Post Weld Heat Treatment (PWHT) to enable cost effective fabrication and repair of steel components in applications where it can be proven that this is not needed. The PROBLEM: PWHT in fabrication, often a very difficult and high cost operation, affecting productivity and not justified for recently developed steels. Repair welds are often non-code compliant and require long validation and justification work resulting in lost production time. BENEFITS: Eliminating intermediate PWHT in fabrication would translate directly into cost savings and competitiveness. A validated repair procedure would reduce repair costs and plant down-time. If repairs could be implemented in codes of practice in the same way that small surface defects can be removed by grinding, millions of euros could be saved each year in industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cross-kingdom symbionts: plant pathogens as insect mutualists.' in the context of a Horizon Europe call.

assistant: **Objectives**

By vectoring plant pathogens, herbivorous insects are key determinants in the epidemiology of numerous plant blights. For a vector-borne phytopathogen, natural selection favors upgrading insect fitness to enhance transmission to an uninfected plant. It is currently unclear how a microbe balances this dual symbiotic lifestyle, featuring markedly different interaction outcomes: as a plant pathogen and an insect mutualist. Likewise, little is known about the molecular mechanisms underlying pathogen specificity, and the genomic basis and consequences of cross-kingdom host shifts along the parasitism-to-mutualism continuum. I will tackle these questions using an emergent model system: the interaction between the fungal pathogen Fusarium, the leaf beetle Chelymorpha alternans, and their shared host plant Ipomoea batatas. I recently described that C. alternans associates with a fusarial strain that coats the pupae of its host, protecting beetles against predators during metamorphosis. In exchange, the insect propagates its symbiont to its host plant, where it causes wilt disease. The unique biology and tractability of this study system affords unparalleled opportunities for experimentation. My approach will combine fieldwork and bioassays, with the latest developments in sequencing technologies, reverse genetics and metabolomics to characterize (1) the mechanistic features of symbiont-driven defense, (2) the genetic basis of infection in a cross-kingdom host-shift, (3) the genomic consequences of a dual symbiotic lifestyle, and (4) the breadth, origin as well as partner fidelity and chemical stability of a pathogen-vector interaction. Bridging the fields of chemical ecology, plant pathology and natural product research, this project will significantly further our understanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Inhibiting mechanotransduction for the treatment of pancreatic cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Mechanical forces transmitted between cells and their microenvironment drive cell function and regulate tumorigenesis. Due to this importance, our FET PROACTIVE project MECHANOCONTROL aims to understand the molecular mechanisms by which forces exert their role, and their implications in the specific application of breast cancer. In this context, we have recently identified that the interaction between the cytoskeletal molecules vinculin and talin can be inhibited by a vinculin fragment (VD1) which blocks cell response to mechanical forces, and the activation of the major oncogene YAP that occurs in tissues with abnormally high mechanical stiffness. Both increased tissue stiffness and YAP activation drive tumor progression in most solid tumors, and thus inhibiting talin/vinculin interactions has a major potential as a therapeutic approach in several solid cancer types. We have designed and synthesized peptido-mimetic drugs reproducing the action of VD1. Among those synthesized, we have identified one that inhibits the metabolism of cell lines from pancreatic, colon and prostate tumors. Our aim is to valorize these drugs in the specific case of pancreatic cancer, which is a clear unmet clinical need since it is the one with the least therapeutic alternatives and worst prognosis. Specifically, the funding from this project will pay for the national phases of the current patent (PCT/EP2017/056410), regulatory pharmacokinetics/pharmacodynamics and toxicity tests in mouse animal models, as well as for developing contacts of potential license-takers to close a license agreement. Because the focus is on pancreatic rather than breast cancer, and on bringing a specific drug to the market rather than carrying out research, this project is related to but falls out of the scope of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Technology development programme towards a European Extremely Large Telescope' in the context of a Sixth Framework call.

assistant: **Objectives**

The project covers the development of enabling technologies and concepts required for the eventual design and construction of a European extremely large optical and infrared telescope, with a diameter in the 50- to 100-m range. To this end, it builds on existing European design studies, on leading industrial and academic expertise in the relevant fields, and gathers resources accross the European academic and industrial communities for a preparatory effort on crucial components, subsystems and concepts. The technology development programme which is the subject of this project will span over the 2005-2008 period. It covers relevant design and technology aspects underlying the feasibility of giant telescopes. As such, it includes, most notably, the deve lopment and testing of advanced adaptive optics technologies and concepts, of metrology systems and control schemes for segmented, active telescopes, as well as the development and testing of advanced materials and processes for the serial production of mirror segments, of low-cost drive sytems for the telescope kinamtics. Site characterization, exploratory instruments designs, and an assessment of the performance of a segmented aperture exopsed to wind on a representative site are also included.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Co-ordinated studies in view of the future round of multilateral trade negotiations in the agriculture and food sector' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of this project is to co-ordinate a task force working on the preparation of the next round of multilateral negotiations in the agriculture and food sector. The project will provide a set of studies, in connection with policy-makers, involving: i/ Comprehensive economic analyses of the main issues of the next round; ii/ Quantitative assessments of the economic impact of the World Trade Organisation proposals on EU agriculture. This includes simulations on reforms of common market organisations which may be necessary to comply with these proposals; iii/ Assessments of the forecasted effects of the trade agreement proposals on world prices, EU exports and imports, with a special effort on databases and indicators on trade and tariffs for the EU as well as other major trading countries; iv./ Assessments of the effect of the proposed regulatory reform" on the EU agro-food industry, with special attention paid to the trade effects of food standards and food labelling. The project is organised in three tasks.Task 1: Analyses and simulations on the international environment, trade statistics and protection and support indicators. This includes the development of a database on trade, tariffs and market access commitments. A second step is the analysis of indicators of trade restriction, domestic support and protection, to assess the consequences of using particular indicators as a basis for an international agreement on market liberalisation, in terms of actual constraints on the Common Agricultural Policy. An existing world trade model will be revised to include nontariff trade barriers as well as domestic payments. The purpose is to analyse the development of the world market environment and world market prices and to integrate this environment in sectoral policy simu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Practical Approximation Algorithms - Proof of Concept' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nowadays, we witness that more and more information is stored and managed in a digital way. Moreover, very often processes are executed and planed by computers. This allows applying computer methods to optimize performance of our actions on an unprecedented scale. This is clearly visible in the case of eCommerce, where the main arena of operation of companies is handled solely using computers. Typically, machine learning tools and algorithms are widely used, e.g., for the prediction of user behavior, user classification, or in recommendation systems. When applying such tools one needs to base his computations on existing historical data. This limits the prediction power of such systems, as we cannot predict the reaction of the users nor of the markets to changes in our strategy. In the case of bidding for Ads in online auctions, we only have full information about the auctions we have won, but in the case of lost auctions we only know that we have lost. Hence, it is almost impossible to predict which auctions we would win using only plain historical data. This problem calls for a novel approach that could extrapolate missing information. Here, we propose the development of such framework together with the programming library that would support such extrapolation. This new framework will incorporate algorithmic game theory into the existing approximation and machine learning algorithms. Game theory gives the right tools to talk about incentives of strategic agents and allows predicting response of market actors to changing conditions. Our idea is to describe these incentives and to build a force feedback loop between market models and algorithmic optimization methods. We will first extract and learn the parameters of the market models from the historical data, only then