RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Learning science the fun and creative way: coding, making, and play as vehicles for informal science learning in the 21st century'.

assistant: **Concept**

The CoM’n’Play-Science project aims to help Europe better understand the new ways in which informal science learning is taking place through various coding, making, and play activities that young Europeans are nowadays increasingly engaged with outside school and higher education science classrooms, beyond the formal boundaries of science education. The project investigates a wide range of loci and modes of this kind of informal science learning, including: a) learning occurring in the context of such activities intentionally organized to achieve informal science learning; b) informal science learning that occurs as a by-product of youngsters’ various coding, making, and play activities that are not intentionally meant for science learning, and which may take place either in organized contexts or independently in everyday life. Carefully positioning the research within the context of the overarching contemporary discourses on STEM/STEAM education, RRI, and science capital, the proposed project aims to shed light on the nature and impact of the informal science learning gained through coding, making and play activities. It identifies diverse practices and looks deeper into a sample of them, whereby participants of real-life activities are surveyed, observed, and gamefully engaged in intensive research. The project further explores the impact of this this kind of informal science learning on: a) formal science education and more traditional informal science learning interventions; and b) scientific citizenship, investigating in particular the attitudes, values and dispositions that young people as learners and as citizens may develop through such activities towards science, scientists, and science-related information in everyday life. The project enables the exploitation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MEDICIS-produced radioisotope beams for medicine' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Pure accelerated radioisotope beams have been used for 50 years in fundamental physics R&D, e.g. for nuclear structure studies (pear shaped exotic nuclei, Nature 2013); CERN-ISOLDE plays a central role in developing accelerator technologies and fostering collaborative approaches to advance this field of isotope mass separation online. Our most recent contribution was the use of nanomaterial targets for more intense and reliable beam production, and laser ion sources for their purification (discovery of yet unknown 233Francium).Radioisotopes are widely used for functional imaging in medicine, based on 99mTechnetium or on 18Fluorine. This field is expected to rapidly expand, when coupling imaging with new cancer treatments, with isotopes emitting different type of radioactivity, e.g. alpha particles. This is shown with the recently introduced 223Radium chloride (Xofigo®) used as a treatment drug in advanced bone cancers. However, either shortage in the supply of 99mTechnetium or lack of access to new radioisotope with adequate properties is a severe treat to develop personalized treatment that combine functional imaging and therapy.Ovarian cancers have poor prognosis, are the second most frequent cancer for women and one of the deadliest. They are difficult to treat, because of possible presence of metastasis, and because this region is difficult to irradiate without collateral damages.MEDICIS-PROMED will train a new generation of scientists to develop systems for personalized Medicine combining functional imaging and treatments based on radioactive ion beam mass-separation. This will be done across a coherent intersectorial multidisciplinary network with world-leading scientists in their field.Subsystems for the development of new radiopharmaceuticals, of isotope mass se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extracellular Vesicle Research Exchanges for Advanced Biomarkers and Therapeutics' in the context of a Horizon Europe call.

assistant: **Objectives**

The EVEREST project is a pioneering consortium in Extracellular Vesicle (EVs) research, bringing together 22 institutions from 11 countries, including 3 UK partners. This interdisciplinary consortium is distinguished by an ambitious plan for over 285 months of staff exchanges, engaging at least 81 fellows. Research-Innovation programme  is structured into four pivotal work packages:1.Combining Expertise and Resources for Advancing Standardised Characterisation and Isolation of EVs: Focused on harmonizing methods for EV isolation across diverse tissues and samples, enhancing the consistency and reliability of EV research.2.Jointly Investigating EVs in Health or Disease, and Enhancing Translational Biomarker Discovery: Concentrated on exploring the roles of EVs in various health conditions and diseases, with a particular emphasis on identifying and validating new biomarkers for diagnostic and prognostic applications.3.Uniting Capacities, Advancing EV-Based Therapeutics or Drug Delivery: Dedicated to developing innovative EV-based treatments and drug delivery mechanisms, targeting key health challenges like cancer and cardiovascular diseases.4.Catalysing commercial development of EV-based technologies: Aiming to bridge the gap between research and practical application, this work package focuses on preparing EV-based solutions for large-scale production and market introduction.At its core, EVEREST is committed to significantly enhancing the capabilities of participating institutions and fostering career advancement for involved fellows. By positioning EVs as critical tools for biomarker discovery and therapeutic applications, the project aims to make substantial contributions to personalized medicine and improved health outcomes, ultimately translating research breakthroug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation of AMPA type of glutamate receptor surface diffusion by Protein Kinase ζ' in the context of a Seventh Framework call.

assistant: **Objectives**

In recent years significant progress has been made into deciphering the initial triggering mechanisms responsible for the induction of synaptic strengthening. Contrarily, very few studies address the question as to which cellular processes are responsible for the maintenance of LTP. Recently, the protein kinase M zeta (PKMζ, an atypical protein kinase C) has taken center stage in the field of synaptic plasticity due to its unique role in the maintenance of LTP. Among some of the most crucial observations are: 1) the increased in PKMζ mRNA level following LTP5, 2) Its protein product is constitutively active, 3) postsynaptic perfusion of PKMζ alone increases synaptic strength, 4) it is necessary and sufficient for the maintenance of LTP. Furthermore, its inhibition reverses pre-established LTP and most importantly erases memories. Therefore this protein merits a primary role in the maintenance of memory traces.Although PKMζ activity is crucial for the persistence of LTP however little is known about its precise cellular and molecular mechanisms of action. Recent evidence point to its role in the rapid redistribution of preexisting surface receptors on the plasma membrane. For example, pharmacologically blocking postsynaptic exocytosis with Botulinum toxin B fails to disrupt PKMζ-induced synaptic potentiation. Meanwhile the same manipulation leads to rapid and persistent rundown of synaptic transmission. Provided that blocking exocytosis is not involved in the PKMζ-mediated effects on synaptic transmission leads me to hypothesize that PKMζ must regulates surface diffusion of AMPARs either by trapping at the postsynaptic density or reshuffling of AMPARs from extrasynaptic to synaptic sites. In this proposal I will test this using a combination of high resolution imaging te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Cellular Radio Access for Broadband Services'.

assistant: **Concept**

Main Objective  The main objective is to develop and demonstrate a cellular radio system to provide broadband interactive digital television and multi-media services through several user and service trials in five areas in Europe. The project involves detailed studies of the systems architecture necessary for implementation and the development of standards vital for future commercial products. Frequency planning and spectrum engineering play an important role in this process. Mechanisms to exploit the technology commercially will be established.  Technical Approach  The project is concerned with cellular radio access to interactive television and broadband services. Based on the definition of user, service and technical requirements, it involves extensive user and service trials in two phases. The project features a detailed study of the systems architecture required for the successful commercial deployment of interactive TV and other broadband services such as fast Internet. Compatibility with MPEG-2 and DVB is paramount. The protocols, modulation and coding schemes which provide optimum solutions in terms of error rates, quality of service and response time are investigated through simulations and technical trials.  Investigations of millimetre wave propagation issues, which are critical in providing both optimum coverage within a cell and limiting interference between cells, will be conducted. The current ACTS projects on radio access, multi-media and ATM technology will also provide relevant and valuable inputs for this project.  Summary of Trial  Technical trials will take place in five locations, Czech Republic, Greece, Italy, Norway and the UK. Four of these will involve investigations of service and user requirements. The trials are performed by cable operators,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrated European –omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases'.

assistant: **Objectives**

Neurodegenerative (ND) and neuromuscular (NM) disease is one of the most frequent classes of rare diseases, affecting life and mobility of 500,000 patients in Europe and millions of their caregivers, family members and employers. This NEUROMICS project brings together the leading research groups in Europe, five highly innovative SMEs and relevant oversea experts using the most sophisticated Omics technologies to revolutionize diagnostics and to develop pathomechanism-based treatment for ten major ND and NM diseases. Specifically we aim to:(i)use next generation WES to increase the number of known gene loci for the most heterogeneous disease groups from about 50% to 80%,(ii)increase patient cohorts by large scale genotyping by enriched gene variant panels and NGS of so far unclassified patients and subsequent phenotyping,(iii)develop biomarkers for clinical application with a strong emphasis on presymptomatic utility and cohort stratification,(iv)combine -omics approaches to better understand pathophysiology and identify therapeutic targets,(v)identify disease modifiers in disease subgroups cohorts with extreme age of onset(vi)develop targeted therapies (to groups or personalized) using antisense oligos  and histone deacetylase inhibitors,  translating the consortiums expertise in clinical development from ongoing trials toward other disease groups, notably the PolyQ diseases and other NMD.To warrant that advances affect a large fraction of patients we limited the selection to a number of major categories, some of which are in a promising stage of etiological and therapeutic research while some others are in great need of further classification. The efforts will be connected through a NEUROMICS platform for impact, communication and innovation that will provide tools and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative Volumetric Capture and Editing Tools for Ubiquitous Storytelling' in the context of a Horizon 2020 call.

assistant: **Objectives**

The INVICTUS project aims at delivering innovative authoring tools for the creation of a new generation of high-fidelity avatars (numerical representations of real humans) and the integration of these avatars in interactive and non-interactive narratives (movies, games, AR+VR immersive productions). The project proposes to (i) exploit the full potential of recent volumetric motion capture technologies that consist in capturing simultaneously the appearance (shape, texture, material) and motion of actors using simple RGB cameras to create volumetric avatars, and (ii) rely on these technologies to design narratives using novel collaborative VR authoring tools.INVICTUS proposes the design of three  innovative authoring  tools: a tool to perform high-resolution volumetric captures of both appearance and motion of characters and that will enable their exploitation in both high-end off-line productions (film quality) and real-time rendering productions. This will ease high-fidelity content creation and  reduce costs through less manual labor.a tool to perform edits on high-fidelity volumetric appearances and motions, such as transferring shapes between characters, performing stylization of appearance, adapting and transferring motions. This will reduce manual labor and improve fidelity.a story authoring tool that will build on VR interactive technologies to plunge storytellers in virtual representations of their stories to edit decors, layouts and animated characters, improving productivity and creativity.By demonstrating and communicating on how these technologies can be immediately exploited in both traditional media (films/animation) and novel media (VR + AR) narratives, the INVICTUS project will open opportunities in the EU market for more compelling, immersive and person
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of altered monocyte activity in the long-term potential of peritoneal dialysis as a therapy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Recurrent infection remains the major reason for treatment failure in patients treated for renal failure with peritoneal dialysis (PD).  The underlying hypothesis of this study is that modification of peritoneal monocyte/macrophage biology by PD alters tissue homeostasis, susceptibility to infection and the development of immunity to re-infection, compromising the long-term potential of peritoneal dialysis as a therapy.In spite of their role in peritoneal host defence and tissue homeostasis, the immunobiology of peritoneal macrophages remains poorly understood. Peritoneal monocytic cells derived from PD patients are depleted throughout the course of PD and exhibit increasing signs of immaturity with reduced capacity to respond to LPS compared to peripheral blood monocytes and a propensity to spontaneous activation in vitro.  It has been suggested that these cells are polarised in their immune responsiveness towards an anti-inflammatory phenotype. Our broad experience of mouse models has highlighted extensive macrophage heterogeneity and has established a broad gene expression database.We aim to:1. complete the first systematic and detailed study of the impact of peritoneal dialysis on the monocyte/macrophage system, including the identification of corresponding cellular subsets between mouse models and human.2. assess the impact of this altered cell biology on functional responses of PD monocytic cells to infectious challenge, the regulation of immunity and tissue damage.Our combined experience and novel datasets mean that we will develop a detailed understanding of the functional alterations in the monocyte/macrophage-lineage and the impacts these have on susceptibility to infection and treatment failure. A better mechanistic characterisation of changes in peritoneal m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Training in plant systems biology' (2002-2006).

assistant: **Innovation**

The Department of Plant Systems Biology (PSB) of the Flanders Interuniversity Institute for Biotechnology (VIB)-Ghent University strives to become a centre of excellence in Systems Biology. The Department is extremely well positioned to take a leading role i n this innovative approach, and the education and training of the next generation of top scientists in Systems Biology is one of its main missions.Systems biology requires the integration of three disciplines:I) bioinformatics and computational biology to model networks;II) functional genomics to develop and implement tools for the high-throughput analysis of biological systems; andIII) last but not least biologists to ask the pertinent questions and to develop the right material to answer them.Our Department will provide training in all three disciplines aiming at the acquisition of specific scientific and technological competencies in research as well as complementary skills in management, communication, and knowledge on ethical and IP issues. The broad scientific competence of the department of PSB will create the flexibility required to train all fellows in compliance with their current and future needs laid down in their Personal Career Development plan.The provided training is expected to have a strong structuring effect on the European research system by enhancing the researcher's career prospects. It will position the early-stage researcher at the forefront of a novel scientific field that is rapidly gaining interest in the scientific community worldwide. Thus it will enhance the competitiveness of the European Research Community and enrich Europe's research capabilities. The experience of working in the environment of a research institute like VIB, with its mission to stimulate the translation of scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced modelling of visual information processing' under Fourth Framework.

assistant: **Concept**

This research has combined a fast growing, agro-forestry ecosystem, capable of elevated biomass production, with a large-scale FACE system, one of the few available in the European Union on a forest tree stand. The FACE facility has utilized a novel technology, originally developed by European institutions, based on the release into the atmosphere, at sonic velocity, of pure carbon dioxide instead of an air-CO2 mixture. The research activities conducted at the POPFACE site have drawn scientists from several European countries to integrate physiological observations at the leaf level with measures carried out at the whole tree and also ecosystem scale. Carbon sequestration over the entire crop rotation cycle has been assessed by final harvest of the tree plantation combined with carbon accounting of the root and soil components.