RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Agricultural Robotics and Augmented Reality for Workplace Enhancement and Labor Linkage' in the context of a Horizon Europe call.

assistant: **Objectives**

The agricultural sector is known for its demanding and hazardous working environments, leading to high rates of accidents and health issues among workers. Furthermore, drudgery due to physical work and repetitive tasks diminishes the attractiveness of the sector for youth. Emerging challenges such as digitalisation, technological intensification, structural change, environmental targets, and new risks due to climate change, coupled with global economic implications demand more and more from farmers and farm workers, exacerbate the need for timely information, and have new implications for occupational safety and health (OSH).AGRO-WELL follows a highly interdisciplinary approach to enhance knowledge for technological transitions towards an environmentally, economically, and socially sustainable agricultural sector. It brings together leading scientists from a multitude of OSH-related disciplines, various regions across Europe, key technology providers and farmer representatives.The project will assess farmer needs and explore ways to increase awareness with respect to smart farming. AGRO-WELL builds on five technologies to leverage the potential of robotics, augmented reality, and artificial intelligence to enhance working conditions and farm safety, enable faster and better-informed farm management decisions, and reduce the environmental impact of four different farming systems. Potential effects of the technologies will be multidimensionally assessed. To support market uptake, AGRO-WELL will design and explore the viability of business models based on novel technologies that are predominantly focused on improving OSH. To support other promising technologies, AGRO-WELL will incorporate an open technology competition enabled by cascade funding. All project results will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Conservation and restoration of european cork oak woodlands : a unique ecosystem in the balance'.

assistant: **Objectives**

Despite their ecological, patrimonial and socio-economical importance, cork Oak woodlands in southwestern Europe are vulnerable to intensification or agricultural abandonment. CREOAX will develop the scientific and technical tools for conservation, restoration and extension of cork Oak woodlands. These objectives will be achieved by1-Collections of tree material from various geographical origins and genetic variation2-Studies of physiological responses of cork Oak, mycorrhized or not, to drought and nutrient stresses3-Studies of mechanisms of acorn viability during storage, and development of propagation techniques4-Field trials to test varying management practices and study the performance of selected tree-mycorrhizae couples5-Ecological and economic modelling of impacts of fire and agroforestry on biodiversity, productivity and stability of cork Oak woodlands, and pathways for their restoration or extension.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A novel methodology for the manufacturability of robust CMOS semiconductor gas sensor arrays' (GLASSGAS) targeting Fourth Framework.

assistant: **Abstract**

The aim of the project is the development of a novel methodology for the fabrication of low power semiconductor gas sensors and sensor arrays addressing the application com-petencies of portability, high performance, reliability, endurance and high yield. The project faces two separate challenges, a novel low-power structure and CMOS integration, that both are of interest individually, but especially once combined promise a high performance device. The final device will consist of a gas sensor array fabricated on a thermally isolated silicon diaphragm and with high added value thanks to its combination with on-chip CMOS circuitry. The mechanical structure that guarantees high yield, robustness, endurance and low-power consumption is achieved with the use of a glass cover which is fabricated on wafer level.The project is pro-posed on a two-step basis, being the first for demonstrating the feasibility of the new concept. Three partial demonstrators are defined to tackle the technological risks and pass-fail criteria have been fixed for them. They are defined to assess the compatibility of the gas sensor and electronic circuit technologies, their interconnectability and the manu-facturability of the wafer level packaging glass-silicon structure. The coexistence of high temperatures for sensors and low temperatures for the circuitry on the same chip will be demonstrated with the demonstrators and FEM simulations.The device will consist of a low power semiconductor gas sensor array fabricated on a thermally isolated silicon diaphragm and with high added value thanks to its combination with on-chip CMOS circuitry. The robustness of the structure that assesses high yield and endurance is achieved with the use of a glass cover that is an important part of the structure. Apart o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Deciphering non-genetic determinants and targetability of cancer cell plasticity.'.

assistant: **Innovation**

IntroductionCancer cell plasticity, the ability of cancer cells to change their identity, enables tumors to adapt to hostile environments, aiding metastasis and resistance to treatments. Hence, plasticity is a major unsolved problem frustrating effective treatment. Unraveling the mechanisms underlying cancer cell plasticity is crucial to establish new avenues for cancer therapy. In contrast to adult cancers, many pediatric tumors are driven by a single genetic alteration that fuels their aggressive nature through remarkable plasticity. Despite their differences, pediatric cancers offer a unique platform to investigate cancer cell plasticity due to their genetically clear characteristics. I hypothesize that plasticity can be reversed to differentiate tumor cells and “mature cancer”. GoalBuilding upon previous ERC-StG funding, we have successfully utilized organoid technology, single-cell genomics, and lineage tracing approaches to uncover the origins of various pediatric cancers. Our findings revealed that these cancers exhibit robust yet pharmacologically reversible plasticity at the level of the epigenome. The goal of this proposal is to reverse cell state changes during tumorigenesis to “mature cancer”. ApproachWe will I) apply advanced (spatial) single-cell transcriptomics and epigenomics approaches to a unique cohort of pediatric tumors and metastases to map out cell state changes during disease progression, II) utilize our unique pediatric cancer organoids to interrogate and target hierarchical trajectories with the aim to mature cancer, and III) screen the enhancer-ome to identify non-genetic determinants of cancer cell plasticity. InnovationIntegrating these cutting-edge technologies on patient-derived tissues and organoids will uncover fundamental principles gov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms of Skeletal Muscle Adaptation to Resistance Training in Spinal Muscular Atrophy' (SMA-RT).

assistant: **Concept**

Spinal Muscular Atrophy (SMA) is a debilitating neuromuscular disorder characterised by progressive motoneuron degeneration, which causes muscle atrophy and weakness. By combining pre-clinical studies and a clinical trial, this 36-month Global Fellowship aims to explore the beneficial role of exercise as a therapeutic strategy to support SMA treatment and improve clinical outcomes. During my outgoing phase at Harvard University, I will employ two transgenic SMA mouse models to investigate the skeletal muscle adaptations to overloading, achieved via synergistic ablation, a model historically used to study muscle hypertrophy and mimic human resistance training. In WP1, I will investigate the muscle morphological, functional, and transcriptomic responses to overloading in SMNΔ7 mutant mice, which, similarly to patients, present ubiquitous SMN deficiency and lifespan extension via pharmacological treatment. In WP2, I will perform the same overloading protocol and similar analyses on a mouse model presenting SMN knockout restricted to muscle satellite cells (Pax7:SMN-KO). While ubiquitous SMN deficiency triggers motoneuron degeneration, this model enables to focus on the role of satellite cells in SMA by deleting SMN selectively in these cells. During my incoming phase at the University of Padova, I will assess whether the molecular mechanisms underlying muscle adaptation identified in mice are translatable to humans, examining the response of SMA type III/IV patients, presenting the milder form of SMA, to a resistance training intervention (WP3). I will employ musculoskeletal imaging techniques, advanced EMG methods, and muscle biopsy and blood sample analysis to perform a comprehensive analysis, which is lacking to date. This project aims to propose exercise as a novel str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Maturing food footprint tools, solutions, and uptake to accelerate a rapid EU food transition'.

assistant: **Innovation**

There is a recognized and urgent need for better food footprint data to accurately inform the sustainable food system transition as the current knowledge infrastructure is inadequate both in terms of scientific robustness and real-world suitability for regulatory and business decision support. The objective of GREENGROCER is to make foundation-strengthening investments in critical knowledge infrastructure in order to advance food footprint data from lab to application. The project packages investments across over a dozen leading mainstream tools including Trase, HESTIA, CoolFarm, FABIO, and EXIOBASE, which collectively form the foundation of most food footprint data currently in use. Work in GREENGROCER: 1) improves the scientific depth by revisiting long standing weak areas including on subnational supply chain specificity, reliability information, and novel and neglected products and impacts such as spices, seaweed, insect protein, cellular agriculture, cold chain energy use, and seafloor disturbance; 2) makes foundation-strengthening investments that take all models towards full compliance with the EU’s Product Environmental Footprint standards and improve FAIRness and interoperability; and 3) promotes exploitation through multi-stakeholder dialogue between food system researchers, industry, and regulators aimed at prioritising pain points and supporting effective regulation. Finally, to collate data without yet another centralised repository, the project leverages Europe’s competitive advantage in marrying AI with scientific expertise to pioneer a fact-based AI expert which can interact with and gather the rapidly growing volume of food system science. Aimed at the Horizon Europe work program destination of reducing the environmental impact of the food system, GREEN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated femtosecond laser based frequency comb and photonic microwave oscillator' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

In femto-iCOMB, we develop the first integrated femtosecond laser-based frequency comb that can serve as the basis for a wide variety of optical and Radio-Frequency (RF) technologies ranging from high resolution environmental and health sensing to LIDAR and RADAR. Femto-iCOMB is based on the successful EIC-pathfinder project FEMTOCHIP, where we demonstrate an integrated high power femtosecond laser enabling extremely low jitter on chip scale. Here, we tam the free running comb from the integrated femtosecond laser with on-chip continuum generation, carrier-envelope and repetition rate locking to an optical reference to become a fully stabilized femtosecond laser frequency comb (FSLFC) with extremely high frequency stability. We use the femto-iCOMB to pursue photonic microwave oscillators for a variety of applications ranging from autonomous driving to ultra-low phase noise oscillators for advanced signal generators and RF-test and measurement equipment and demonstrate these devices in relevant industrial environments for each application. These prototype field tests will validate the TRL levels achieved for each application and together with surveys of potential customers will inform the business case to be made for each potential product line.


**Keywords:** integrated freqeuncy comb, integrated optics, femtosecond laser, photonic microwave generation, autonomous driving, RADAR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High yield and performance stem cell lab' (HYPERLAB).

assistant: **Concept**

The success of stem cell therapy is highly dependent on a safe and reliable supply of human stem cells and stem cell-derived differentiated cells, which must be assured by efficient and robust culture methods. Current culture of human embryonic and adult stem cells is not optimised (with regards to e.g. media, growth factors, supporting biomaterials, differentiation techniques) and is far from fulfilling the demands in terms of reproducibility and preciseness. Additionally, current methods do not allow fast screening of culture conditions for their systematic optimisation. These limitations currently slow down the development of stem cell applications and will be addressed and overcome by the Hyperlab project. To reach the overall aim of developing new and improved culture methods, media and protocols for stem cell cultivation and differentiation, Hyperlab will adapt novel microfluidics-based cell cultivation technologies to the specific needs of stem cell culture. The developed culture systems will have two major advantages over existing approaches: on the one hand, they will improve stem cell culture in terms of microenvironment control, reproducibility, robustness and efficiency. On the other hand, these microscale technologies, together with developed transgenic readout systems, will allow medium to high throughput screening of culture conditions, enabling determination of optimal protocols in shorter time. Once established, technologies, protocols and conditions will be evaluated for their upscalability and will be made GMP-compliant to form a solid basis for progress in human stem cell therapy. To implement this innovative strategy, Hyperlab follows an integrated approach, bringing together renowned experts from stem cell biology, microsystem technologies, biomate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a prototype manufacturing plant for new artificial composite tiles made of wood and stone. wood & stone composite tiles' (1998-2002).

assistant: **Concept**

The main object of Compo Tiles is to adapt the existing tiles production technology to create composite slabs whose base matrix will be formed by quartz and sands, giving the requested characteristics of resistance and durability to the final product, together with components different quantities of wood fragments inserted in the mixture of the artificial slabs. The random or designed assessment of wood variety fragments will be responsible of the aesthetic characters of the CT for furnishings. This goal will be reached through the implementation of a prototype manufacturing plant to be set up and tested. It is also needed to design the process and define its performance metrics and control systems to provide a clear quantification of the environmental impact of the product; definition of classes of quality for certifying the new produced and to develop an automatic classification system based on surface imaging. The new technology will allow reuse waste materials of stone and wood.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pioneering a New Path in Parallel Programming Beyond Moore’s Law' (BeyondMoore) targeting Horizon 2020.

assistant: **Abstract**

BEYONDMOORE addresses the timely research challenge of solving the software side of the Post Moore crisis. The techno-economical model in computing, known as the Moore’s Law, has led to an exceptionally productive era for humanity and numerous scientific discoveries over the past 50+ years. However, due to the fundamental limits in chip manufacturing we are about to mark the end of Moore’s Law and enter a new era of computing where continued performance improvement will likely emerge from extreme heterogeneity. The new systems are expected to bring a diverse set of hardware accelerators and memory technologies. Current solutions to program such systems are host-centric, where the host processor orchestrates the entire execution. This poses major scalability issues and severely limits the types of parallelism that can be exploited. Unless there is a fundamental change in our approach to heterogeneous parallel programming, we risk substantially underutilizing upcoming systems. BEYONDMOORE offers a way out of this programming crisis and proposes an autonomous execution model that is more scalable, flexible, and accelerator-centric by design. In this model, accelerators have autonomy; they compute, collaborate, and communicate with each other without the involvement of the host. The execution model is powered with a rich set of programming abstractions that enable a program to be modeled as a task graph. To efficiently execute this task graph, BEYONDMOORE will develop a software framework that performs static and dynamic optimizations, issues accelerator-initiated data transfers, and reasons about parallel execution strategies that exploit both processor and memory heterogeneity. To aid the optimizations, a comprehensive cost model that characterizes both target application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'STARTlight: cell cycle START decision unraveled by single-cell microscopy, modeling and optogenetics'.

assistant: **Concept**

Cells across all kingdoms of life have developed exquisite control mechanisms to achieve and maintain the balance between cell growth and division. The decision to commit to cell division is a ubiquitous and essential process, whose dysregulation can dramatically affect cell viability in simple eukaryotes, while leading to tumorigenesis in mammalian cells. In budding yeast, the short interval in late G1 where commitment to cell division is decided, is known as START. Despite years of research, it is still unclear how the transition through START is triggered, and many mutually conflicting hypotheses have been proposed. Recent developments in microfluidics and single-cell microscopy have opened up new avenues for investigating START at the single-cell level. Moreover, thanks to the rapid development of optogenetic tools in the last few years offers the possibility to apply dynamic single-cell perturbations, with great potential for untangling complex intracellular networks. By combining single-cell time-course data on key components of the START network with targeted, reversible and dynamic perturbation of their activities using optogenetic tools, the aim of this proposal is to unravel the mechanisms that trigger START in budding yeast and to quantitatively describe these processes in a mathematical model. The results of this project will thus provide new fundamental knowledge on cell cycle regulation which, thanks to the high degree of conservation between yeast and higher eukaryotes, will be transferrable to other organisms as well.