RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Use of active blank holder techniques to optimize the sheet forming process'.

assistant: **Objectives**

In order to meet future demands on robust processes and on properties of final components more advanced process control in the sheet forming process is necessary. In fact, this is the only way to increase the use of advanced sheet materials as high strength steels, tailored blanks, light weight alloys etc. to the whole car body. This in turn, is a prerequisite for meeting the well known higher demands on lighter and safer cars in future. The blank holder force (BHF) is one of the most important process variables in controlling the sheet forming process for a given tool design. Today, the far most common procedure is to apply a constant BHF during the stroke. It is however, well known that advanced in process control of BHF can provide a more robust forming process, less sensitive to variations in the process. The overall objective for the project is to introduce in process control of the blank holder force in the press shops on a large scale in order to increase productivity, decrease process sensitivity to variations in material and press parameters, and to enhance product quality. The specific industrial objectives are:  To develop new BHF systems based on intelligent gas springs devoted to in process control of BHF in the industrial environment and to provide two complex dies aiming at demonstrating forming of typical geometries for vehicle components (front fender type and engine cover type).  To increase the sheet material yield stress level from 180 to 220 MPa for a front fender type component and to avoid reinforcements through utilization of tailored blanks for a component resembling an engine cover.  To implement closed loop control in a commercially available FE code to be used to define optimal BHFtrajectories for complex dies. To provide a computerized syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'NOVEL THERAPEUTIC FOR THE TREATMENT OF PARKINSONS DISEASE', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project’s goal is to develop a successful treatment that combats severe motor and psychotic symptoms in Parkinson’s disease (PD). PD is a debilitating neurodegenerative disorder affecting > 6 million people worldwide. It’s the neurological disorder with the highest increase in death rates, prevalence, and disability-adjusted life-years (DALYs). Levodopa, introduced more than 50 years ago, remains the most prescribed treatment for the symptomatic relief of PD, although its long-term use leads to the development of motor complications, i.e. levodopa-induced dyskinesia (PD-LIDs).IRLAB aims to address the challenge in PD treatment by clinically validating its novel compound, IRL790, aimed at reducing symptoms of PD-LIDs and Parkinson’s disease psychosis. IRLAB’s programme is based on its proprietary drug discovery platform, Integrative Screening Process (ISP), which captures a better understanding of complexities of CNS-related diseases, such as PD, and yields drug candidates with superior chance of success in the clinic.IRLAB’s therapeutic will improve intervention outcomes for PD patients in two indications. Its safety and tolerability have been validated in Phase I clinical trials and its therapeutic efficacy in PD-LIDs is being evaluated in an ongoing Phase II study. Results are expected 2018. Besides medical benefits to patients, IRL790 has also the potential to bring cost-savings to healthcare providers by effectively reducing the Parkinson’s disease burden.Generation of high quality clinical data will improve IRLAB’s opportunities for out-licensing. We plan to apply for SME grant to accelerate clinical developmental and take IRL790 through a Phase II study in PD psychosis. This way, we will out-license and market the drug sooner and for two indications (PD-LIDs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanical and systemic control of growth during Drosophila abdominal development' to be submitted under Horizon 2020.

assistant: **Abstract**

Control of tissue size during animal development is of crucial importance to achieve the correct body/organ size and shape, and it underpins the evolution of animal size and architecture. How is tissue size tightly controlled during development? How is each cell in a developing animal instructed to stop growing and dividing when the correct body size and shape has been reached? Answers to these questions are of fundamental importance to our understanding of diseases such as cancer as well as for regenerative medicine. Using the development of the Drosophila abdominal epidermis as a model, we will perform long-term quantitative in vivo analysis of cellular behaviours and generate fluorescent live reporters of growth-promoting pathways to correlate activity patterns with developmentally regulated growth phases. We will manipulate tissue mechanics as well as nutrient-sensing pathways to understand how nutrient availability and tissue-intrinsic physical properties are integrated to specify final tissue size. In combination with computational modelling, we aim to generate a better understanding of developmental growth, as well as the mechanisms that trigger tissue growth arrest. The mechanisms regulating how cell proliferation is triggered in response to extrinsic and intrinsic stimuli and the transitions between different proliferative/growth states, particularly in tumour cells or regenerative tissues, are poorly understood. As these events are precisely defined in Drosophila abdominal morphogenesis, we hope to uncover the internal logic modulating cell cycle/growth rates transitions that can be used as a genetically tractable paradigm for the study of equivalent processes in cancer, regeneration or development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Label-free 3D morphological nanoscopy for studying sub-cellular dynamics in live cancer cells with high spatio-temporal resolution'.

assistant: **Objectives**

Label-free optical nanoscopy, free from photobleaching and photochemical toxicity of fluorescence labels and yielding 3D morphological resolution of <50 nm, is the future of live cell imaging. 3D-nanoMorph breaks the diffraction barrier and shifts the paradigm in label-free nanoscopy, providing isotropic 3D resolution of <50 nm. To achieve this, 3D-nanoMorph performs non-linear inverse scattering for the first time in nanoscopy and decodes scattering between sub-cellular structures (organelles).3D-nanoMorph innovatively devises complementary roles of light measurement system and computational nanoscopy algorithm. A novel illumination system and a novel light collection system together enable measurement of only the most relevant intensity component and create a fresh perspective about label-free measurements. A new computational nanoscopy approach employs non-linear inverse scattering. Harnessing non-linear inverse scattering for resolution enhancement in nanoscopy opens new possibilities in label-free 3D nanoscopy.I will apply 3D-nanoMorph to study organelle degradation (autophagy) in live cancer cells over extended duration with high spatial and temporal resolution, presently limited by the lack of high-resolution label-free 3D morphological nanoscopy. Successful 3D mapping of nanoscale biological process of autophagy will open new avenues for cancer treatment and showcase 3D-nanoMorph for wider applications.My cross-disciplinary expertise of 14 years spanning inverse problems, electromagnetism, optical microscopy, integrated optics and live cell nanoscopy paves path for successful implementation of 3D-nanoMorph.


**Keywords:** Label-free nanoscopy, live-cell imaging, super-resolution, inverse scattering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling glacier response after Larsen B ice shelf collapse' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project aims to improve our understanding of glacier and ice sheet dynamics in a warming climate, leading to a better forecast reliability for future sea level rise. The main objective is to provide more accurate estimates for the loss of grounded ice in the Antarctic Peninsula, caused by the melting and collapse of its ice shelves over the last decades. Increased losses of grounded ice have been observed at several places, in particular for the Larsen B Embayment glaciers which sped up and thinned after the collapse of the Larsen B ice shelf in 2002. In order to reduce the present uncertainty in Antarctic contribution to sea level rise, it is of the utmost importance to better understand the dynamics of such coupled glacier/ice shelf systems. This project will investigate this dynamics using a combination of improved datasets and improved numerical modelling techniques, available at the British Antarctic Survey. It will be the first ever attempt to simulate glacier response to ice shelf collapse beyond the flow-line approximation, providing a significant structural improvement towards more realistic simulations of such events. A comprehensive study of the Larsen B Embayment will be used to test the model, and numerical experiments will be performed to simulate similar events in the future. A prime study area will be the Flask and Leppard glaciers on the Antarctic Peninsula, which feed the vulnerable Scar Inlet, and which are closely monitored by the British Antarctic Survey.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scalable privacy preserving intelligence analysis for resolving identities' (SPIRIT).

assistant: **Innovation**

SPIRIT project takes up a holistic approach to identity resolution and will develop a semantically rich sense-making capability to facilitate cognitive tasks in the resolution of identity in full operational compliance with data and privacy protection as operationally assured through workflow-embedded data anonymisation and privacy filtering techniques as required, whilst retaining maximum possibly informativeness of data that can be legally used. Thus SPIRIT  will provide capabilities to continuously initiate complex associative searches over all sources relevant to the current investigation, correlate information from multimedia data, reason over information with uncertainty, and structure and manipulate information into a unified view of the available evidence over a persisted, searchable knowledge base. The final goal is to empower the investigator to create a semantically rich picture over all the available evidence to be presented at court.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Partitioning: new solvent extraction processes for minor actinides' (PARTNEW).

assistant: **Innovation**

In the framework of the development of new Partitioning & Transmutation strategies of the nuclear wastes generated after reprocessing of spent fuels we propose to develop solvent extraction Partitioning processes of americium and curium. These elements are present in the high active effluents issuing the reprocessing of the spent fuel at the trivalent state. Consequently, their separation from these acidic effluents from the other elements (fission products), and particularly the trivalent lanthanides (Ln(III), is a difficult task. We propose to develop multi- cycle processes able to separate these elements from acidic raffinates or concentrates.The main extractants to be developed are:(i) the diamides,(ii) nitrogen polydendate ligands,(iii) acidic sulphur-bearing ligands.Combinatorial synthesis will be used to prepare selective extractants. Basic research and process developments will be carried out for all the systems studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modern approaches for career development in small-grain cereal breeding' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The CAREBREED project, based at the multi-disciplinary Institute for Research of Environment and Sustainability, Newcastle University (NU), UK will deliver high quality training over 2 years to a talented Serbian small-grain cereals breeder in uses of molecular marker technologies and phenotyping to characterize unique wheat genetic stocks. Series of near-isogenic lines (NILs) have been produced to target 18 regions of the bread wheat genome where major quantitative trait locus (QTL) clusters for yield, its components, phenology, leaf dimensions and antioxidant contents were previously located using 95 wheat doubled haploid lines from the cross Chinese Spring (CS) x SQ1. The project will deliver training in using microsatellite (SSR) markers and their applications in modern cereal breeding, including marker-assisted breeding, making genetic maps and QTL analysis. After familiarization with DNA protocols the fellow will screen 180 NILs with 20 SSR markers to delineate sizes of introgressed donor segments from CS into SQ1, their relations to targeted QTLs and the extent of background genome heterogeneity. In parallel experiments, NILs will be grown under control and stressed pot conditions of drought and abscisic acid stress-hormone treatment and ozone exposure in open-top chambers, measuring traits for which the original QTL clusters were selected to identify environmental triggers for these QTLs. Crosses between NILs differing in yield QTLs will be made to test the extent to which yield QTLs are additive. The Fellow will visit the John Innes Centre, Norwich for 3 months to be trained in manual SSR genotyping and other modern marker systems. The project finishes with a period of writing up at Newcastle and planning for the future. A comprehensive programme of generic ski
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improved control of smelt conditions and solidification for precisi on casting of non-ferrous metals' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Automatic monitoring & control of the smelt state, of casting conditions and of solidification, is important for all kind of casting processes and esp. for precision casting of special metals like titanium and its alloys. While the monitoring of casting is well established for standard metals, no practical solutions are available to date for following processes and problems: monitoring of the solidification for all kinds of metals in view of crack evolution, homogenity, surface quality etc.; monitoring & control of the smelt state of metals with high melting temperature in order to identify correctly the melting point and avoid overheating (e. g. Ti, Ti alloys, Cr Co, Co Ni, etc); monitoring of smelt state at continuous thin strip casting of stainless steel and non ferrous metals. The lack of sufficient equipment is mainly due to the fact that a non contact mesurement technique is required which can cope with the severe conditions. Acoustic (ultrasound) emission has been identified to provide a feasible solution for these problems. For cast control at induction and arc smelters, AE analysis can possibly be supported by power and frequency analysis of electric current. Main project objectives are to develop a non contact measuring device for monitoring & control of smelt and solidification conditions; quality improvement of casted non ferrous metals through on line monitoring of solidification; for special metals casting (esp. Ti / alloys), to achieve a substantial reduction of process scrap (60 %) and costs through automatic monitoring & control of the smelt state. This will also lead to an important improvement of working conditions by avoiding very difficult vision control. Three SME partners active in precision casting of non ferrous and special metals, are aiming at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New technology for the synthesis of the brevetoxins' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The project will involve the development of new methods for the construction of the medium-ring cyclic ether units found in the brevetoxins and related marine natural products. Catalytic ring-closing metathesis reactions will be used to accomplish ring closure, providing 6- to 8-membered cyclic allyl ethers or enol ethers in high yield. The functionalistion of these cyclic ethers a their elaboration to bicyclic and tricyclic sub-units the brevetoxins will also be explored. Training content (objective, benefit and expected impact) The project will provide experience of several state-of-the-art synthetic methods. In particular, the use of metal alkylidene complexes for catalytic ring-ctosing metathesis reactions, and the application of carbenoid insertion reactions to organ synthesis. The project will involve the preparation and use of air-sensitive metal complexes and will provide experience of techniques that are normally restricted to organometallic chemistry. Links with industry / industrial relevance (22) Ring-closing metathesis has attracted an unprecedented amount of interest in recent years and seems destined to become the most generally applicable reaction for ring construction in organic synthesis. The work outlined above will demonstrate value of metathesis reactions for the efficient construction of rings. In addition, this work will allow the preparation of unnatural brevetoxin analogues which may possess interesting biological properties and permit the mode of action of the brevetoxins to be elucidated. Much of the brevetoxin work already performed in Dr. Clark's group has been industrially funded.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Voltage Shield Stabilizer Regulator', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The mission of Castoldi&Moretti (C&M) is to design, produce and commercialize devices for electrical grids’ control and in particular voltage stabilizers and other devices that have similar aims. The growing % of unstable and unpredictable renewable energy sources (RES) used for power production and the wider presence of distributed generation alters the current standards for electric grids and creates further disadvantages in terms of voltage fluctuations, and thus strengthens the demand of voltage stabilizers in industrialized and emerging countries. The innovative voltage stabilizer SSR-Shield Stabilizer Regulator can stabilize the voltage level at the nominal value for fluctuations up to ±20% (compared to ±10% of competitors). Differently from current solutions available on the market, in SSR the voltage is controlled in continuous way and not by steps. This is done by means of a brushless motor that automatically and dynamically adjusts the position of a mobile isolated, short-circuited coil over the fixed coil in the magnetic core. The other very innovative element is the fact that its magnetic core will be made of amorphous materials, which limit losses (-20%) with consequent 20% energy savings and 8% CO2 emissions. In terms of revenues, they will move from 3,0M€ in Y1 to 21,0M€ in Y5, and cumulative EBIDTA will be 20,19M€ by Y5. With a further investment of 970K€ to finalize SSR, the ROI will be 12,44. Thanks to the above-mentioned figures, C&M will be able to hire 29 new staff. It has to be highlighted that C&M aims not only at entering the current global market for voltage stabilizers but at creating a new market that, because of the high costs and low performance of competing solutions has never been properly addressed.This new market comprises small and medi