RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SYSTEMS FOR ADVANCED MANAGEMENT OF PUBLIC TRANSPORT OPERATIONS' (SAMPO) under Fourth Framework.

assistant: **Objectives**

Better opportunities for mobility through integrated demand-responsive public transport services (including minibuses, taxis, etc.) are the central objective of SAMPO, with special emphasis on the needs of elderly and disabled people. Advanced transport telematic (ATT) tools to support integrated, multi-modal transport will encourage efficient use of resources and less external funding. SAMPO will identify the needs of key users and tailor services to meet them. A vigorous awareness exercise is expected to boost ATT take-up by buses and taxis. Initial indications are that the proposed technologies may cut expenditure on special transport services by up to 20%.Objectives: The core objective of the SAMPO project is to improve the possibilities of mobility of citizens in rural and urban areas through the provision of integrated Demand Responsive Transport Services (DRTS). In particular, it seeks to increase the participation of disabled and elderly people (and others with barriers to travel) within their community by allowing their needs to be met by flexible transport.Summary description: The use of integrated Advanced Transport Telematic (ATT) tools to support integrated, multi-modal passenger transport services allows more efficient use of transport resources in a manner which is viable to the operator and which will reduce the need for external financial support. Sites in Belgium, Finland, Ireland, Italy and Sweden will identify the travel-related needs of key user categories, and will implement and/or adapt transport services which meet these needs. ATT tools are integrated to build up supporting systems using a general SAMPO system architecture and common functional specification framework as a reference. Travel Dispatch Centres using mobile data communication, GPS l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The mechanical evolution from biting-chewing to piercing-sucking in insects'.

assistant: **Objectives**

Insects are extremely efficient feeders that impact on the world's ecosystems and our agriculture with their feeding capabilities. Insects evolved diverse mouthpart types during ~400 million years of evolution which allowed them to conquer many food recourses. How this feeding system evolved, in particular the transition from one mouthpart type to the other, is unclear. My idea represents the first extensive assessment of insect head mechanics applying latest semi-automatic workflows and engineering approaches to unravel the factors driving insect mouthpart evolution and performance. Specifically, I will study the mechanical evolution from early biting-chewing to piercing-sucking mouthparts and head types, considering recent as well as fossil species. In contrast to earlier studies, I aim to quantify mechanical evolution for the whole head which has never been attempted before for insects. This will be done using engineering software to simulate insect feeding, followed by 3D shape analysis and finally evolutionary modelling using algorithms based on likelihood models of evolutionary processes. The project is therefore positioned at the interconnection between experimental biology, engineering and biological simulation.The results will impact our understanding of insect evolution, with the project identifying which mechanical factors made insects such extraordinarily successful feeders, and why their mouthparts evolved into so many different types. To achieve an integrative understanding, my idea will furthermore take into account ecological, evolutionary and life history factors. Understanding the mechanical head evolution has never been tried before in a systematic way at this scale. However, my project idea also delivers results for industry: Since modern engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biological consequences of global climate change. The effects of salinity and temperature in extremophilic algae.' (EXTALGAE) targeting Sixth Framework.

assistant: **Abstract**

The overall goal of this project is to investigate the physiological and chemical adjustments incurred by photosynthetic algae to parameters affected by global climate change, namely changes in salinity, temperature and light. Furthermore we are aiming to contribute to European scientific research by filling an important gap in climate modelling systems by examining and potentially enabling the prediction of volatile organic sulphur compounds (VOSC) production in marine algae. Aquatic phytoplankton have two important roles in global geochemical cycles affecting climate change. First, through photosynthesis they assimilate 40 % of all CO2 flowing through the global carbon budget. Second, marine algae can contribute to global sulphur fluxes through the product ion of volatile organic sulphur compounds (VOSCs). These processes work in parallel to counteract global warming by fixing carbon while the production of VOSCs counteracts global warming through enhanced cloud albedo. Of these latter compounds, dimethylsul phonioproprionate (DMSP) is the primary source of global sulphur and contributes between 48-100% of the sulphur fluxes in the subpolar North Atlantic waters. The ability to predict the concentration and fluxes of DMSP in the ocean as well as the release of its degradation products into the atmosphere would greatly enhance climate modelling and to our knowledge has not been possible. During this action we wish to advance the understanding of the regulatory mechanisms governing the biosynthesis of DMSP in alg ae. An extremophile isolated from the water column in a permanently ice-covered Antarctic lake will be used as a highly sensitive test organism for these studies as relatively small disturbances in the environment result in large physiological responses. T his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Internalist vs externalist evolutionary biology: do we need a New Synthesis?' in the context of a Seventh Framework call.

assistant: **Objectives**

The theory of evolution is fragmented by two different views of life: the externalist and the internalist perspective. From the formulation of the theory of natural selection by Darwin, in 1859, externalist view has dominated in evolutionary thought. In the last decades, internalist perspective has recovered vigour in the light of recent empirical advances in molecular genetics. An alternative theory is emerging. The major aim of this project is to contribute to the development of a common conceptual framework that will eventually facilitate a true integration of these century-old perspectives. We will reach the philosophy of science to analyse the conceptual framework of these evolutionary theories. Furthermore, in an effort to show the importance of the philosophy for science, the second principal goal consists to finding out exactly what is implied by the contrast between the two perspectives, as far as empirical claims are concerned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Cloud to Star Formation' (CSF).

assistant: **Concept**

Star Formation is a hierarchical process from the build-up of large clouds to the assembly of stars. This ERC project aims at studying the multi-scale processes of this conversion from diffuse gas to stars. The fundamental data are provided by two PI-led large observing programs at two of the most advanced radio and mm interferometers, the Very Large Array (VLA) and the Plateau de Bure Interferometer (PdBI). This combined approach is designed to address outstanding key questions in the field of cloud and star formation.The 225 hours THOR program at the VLA investigates the cloud formation and conversion of atomic to molecular gas, as well as feedback processes back to the interstellar medium (ISM). To reach these goals, THOR observes the Milky Way in atomic HI, molecular OH, and cm continuum and radio recombination lines tracing the ionized components of the ISM.  At smaller spatial scales, the 300 hours PdBI project CORE will study the fragmentation of the gas clumps to form clusters, the formation of accretion disks and outflows, and the gas infall rates as proxy for the accretion rates. Therefore, assisted by Atacama Large Millimeter Array (ALMA) observations, we will investigate a sample of high-mass star-forming regions at the highest spatial resolution of 0.2'' to dissect the physical processes during the assembly of the highest mass stars. The core aim of this ERC project is to study all spatial scales from molecular clouds to individual massive cores. This will be a decisive step in the understanding of the conversion of gas and dust into stars. Through his decade-long expertise and leadership in star/cloud formation, the PI is uniquely positioned to advance the field significantly. The surveys at the heart of the program are extremely computing and work intensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional Measurements IN-THE-KIDNEY to Diagnose, Understand and Treat Renal Tubulopathies' (IN-THE-KIDNEY) under Horizon Europe.

assistant: **Objectives**

BACKGROUND | Renal tubulopathies are a large group of genetic disorders that disturb the function of the kidney tubule. A major challenge for diagnostics and treatment of magnesium (Mg2+) wasting tubulopathies, is absence of functional cell models and tools to study the pathophysiology. Diagnostics of hereditary Mg2+ wasting tubulopathies based on genetic screening, rather than biological measurements of kidney processes. Therapy largely depends on oral supplements because therapeutics that target the cause of disease are not available. VISION | In my vision, better insights in the cellular functional processes in the kidney are the next essential step forward towards better diagnostics, pathophysiological understanding and development of therapy. Development of functional Mg2+ transport measurements and innovative use of patient-specific models is required to increase diagnostic yield and to develop therapy.  AIMS AND APPROACH | In this project, I aim to develop a urine-based diagnostic approach using scRNA sequencing and extracellular vesicle proteomics to provide biological diagnosis of renal tubulopathies. Using urine-derived adult stem cells, I will perform the first ever functional studies of ion reabsorption in kidney organoids. This approach allows personalized analysis of the pathophysiology as well as patient-specific drug screenings. Lastly, I will be the first to apply intravital multiphoton imaging in mice to measure Mg2+ reabsorption in the kidney tubule. The combination of patient-derived organoids and mice models will be used to test novel therapeutics. IMPACT AND INNOVATION | IN-THE-KIDNEY establishes the novel concept of biological diagnostics for renal tubulopathies, develops for the first-time patient-derived tissue models for functional analysis and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Brain cell type-specific interactions and schizophrenia' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Schizophrenia is a heritable but genetically complex disease. Pathological and epidemiological data fit a model of SCZ as a network disease with perturbations during brain development leading to early-adulthood onset clinical symptomatology. Our present understanding is based on single markers or arrays of gene expression from tissue samples containing multiple cell types. As a consequence, pathological changes in the function of inhibitory or excitatory neurons, microglia, or oligodendrocytes have variously been proposed to be the cause of symptoms. In light of recent data I hypothesize that it is unlikely that the various cellular SCZ-pathologies all arise independently from genetic alterations in multiple cell types. Recent findings from my lab show that in the cortex the expression of risk genes for SCZ are enriched in excitatory neurons, and that this set of risk-genes is largely non-overlapping with those expressed in other cell types. I propose that pathological genetic changes in excitatory cells ultimately initiates pathological changes in other cell types contributing  to the multiple cellular pathologies observed in SCZ. We will:1. Identify cell type-specific gene regulatory networks involved in SCZ (SCZ-GRNs) in prefrontal cortical excitatory cells by analysis of four distinct SCZ mouse models.2. Confirm putative SCZ-GRNs in patient material using in situ transcriptomics on postmortem brains and connect to clinical features via collaboration with genomic studies in Sweden and Denmark.3. Functionally investigate the effects of perturbing excitatory cell SCZ-GRNs on other cell types.Single-cell RNA-seq, providing insights into the molecular properties of individual cells, and modern molecular tools for perturbing transcription in a cell type-specific way opens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reducing Carbon Footprint for Generative AI' in the context of a Horizon Europe call.

assistant: **Objectives**

Executive summary:Generative AI systems, such as chatGPT, recently passed the Turing test, forever transforming human-machine interaction. These systems provide giant productivity leaps across many sectors. However, their energy requirements increase nine-fold annually and their abundance grows at exponential rate. The resulting carbon footprint becomes significant. IT giants such as Google, Nvidia, Microsoft, and Amazon, as well as many mid-sized companies, have committed to reduce their carbon footprint. The EU is strengthening regulation for emission reductions. But the new generative AI trend jeopardizes emission reduction commitments.Most power consumption of generative AI is spent on matrix multiplication. Our novel solutions reduce energy consumption and carbon footprint by replacing current matrix multiplication algorithms with more efficient ones. These can be implemented on existing hardware and software stacks. Potential energy saving predicted at about 40-50%, while maintaining performance and accuracy.The novel developments of Prof. Oded Schwartz and his strong team are based on years of research, and protected by patents. The funds are requested to pursue business opportunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multimodal mossy fiber input and its role in information processing in the cerebellar granule cell layer' (MULTIMOSSY) targeting Seventh Framework.

assistant: **Abstract**

Synaptic connectivity within and between neurons in brain networks determines the flow of information, how signals are combined and how they are transformed. However, our understanding of information processing in brain networks remains poor. The cerebellar cortex is an attractive model to study network processing because it consist of relatively few, well defined cell types and a relatively simple structure. The cerebellum is involved in motor coordination, and the maintenance of balance. It receives both sensory and motor inputs and integrates this information to perform its function. However, at the cellular level, the specific connectivity of mossy fibres (Mfs; the major input to the cerebellar cortex) and their integration is uncertain. This proposal focuses on Mfs arising from different precerebellar nuclei conveying both sensory information and motor command signals. Mfs contact Golgi cells (GoCs) and granule cells (GCs) in the cerebellar granule cell layer (GCL). However, the connectivity rules, and thus the integration of different Mf inputs onto these cells remain poorly understood. To tackle this question, I propose a multidisciplinary approach based on electrophysiology, optogenetics, 2-photon microscopy and network modelling. I will describe the functional connectivity between Mfs and GoCs and GCs by infecting distinct precerebellar nuclei with Channelrhodopsin (ChR)-expressing adeno-associated viruses to label and activate Mfs. I will measure the synaptic weight and plasticity of these connections. Using variants of ChR activated by distinct wavelengths, I will examine whether individual GoCs and GCs receive multimodal information from distinct nuclei. The results will be included in a detailed 3D network of the GCL and spatio-temporal dynamics and process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring the X-ray Transient and variable Sky' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A wide diversity of astrophysical phenomena - from stellar flares in the solar neighborhood to accretion in galactic nuclei at cosmological distances - are characterized by flux and spectral changes on time scales ranging from a fraction of a second to several years. Every day, observing facilities with time-resolved imaging capabilities collect huge amounts of potentially interesting information, which remains mostly unused, stored in data archives. This is especially true in the high energy range of the electromagnetic spectrum, where source variability is very common but the time dimension  is seldom systematically exploited.Treasuring on the experience of our European team, we propose an unprecedented program to search and characterize variable sources in the soft X-ray energy range. To do so we’ll exploit the whole database collected by the EPIC cameras onboard the XMM-Newton mission. This will include a search for fast transients, missed by standard image analysis, as well as a search and characterization of variability in tens of thousands of sources on a broad range of time scales.X-ray results will be complemented by multiwavelength characterization of all previously undetected sources. Phenomenological classification of variable sources will also be performed. Our project will certainly unveil new and unexpected classes of sources (as has always been the case when a new region in parameter space has been explored) enhancing the potential of discovery of the XMM-Newton mission, in itself the most productive observatory of the European Space Agency. All our results will be made publicly available, together with new analysis tools. Our variable source catalogue will trigger reanalysis of other databases as well as new observations and will become a reference in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Singularity formation in nonlinear evolution equations'.

assistant: **Innovation**

Non linear wave equations are central in the description of many canonical models in physics from nonlinear optics to fluid mechanics. A phenomenon of particular interest is singularity formation which corresponds to the concentration of the energy of the wave packet. The existence and description of such dynamics is still mostly mysterious, but fundamental progress have been made in the past ten years on canonical models like nonlinear wave and Schr\""odinger equations, with in particular the discovery of the fundamental role played by a specific class of nonlinear wave packets: the solitary waves. These very recent works open up a huge field of investigation on problems which were considered out of reach ten years ago. The aim of the SINGWAVES project is to strenghten our research group in the setting of an intense international activity with two main directions of investigation: the construction and classification of singular bubbles for some canonical models like non linear Schr\""odinger equations, the exploration of new deeply nonlinear dynamics in connection with classical models at the frontier of current research.""