RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DYNAMICS OF ORGANIC MATTER IN ESTUARIES IMPACTED BY AGRICULTURAL ACTIVITIES' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

During the European's FP7, 19 European research projects focused on eutrophication, have been funded over 377 of the environment section, showing the relevance of the topic, which was recently listed as one of the most severe threat to human water security and biodiversity causing severe damages to the economies. Despite mitigation measures reducing the nutrients loads, harmful algal blooms still occur, possibly due to changes in fertilizer uses. Indeed organic matter (OM) and particularly N-containing organic matter like urea which is the most widely used fertilizer, is an important source of N for a large variety of marine phytoplankton, ranking often in importance greater than inorganic N like nitrate. Despite its lower concentration compared to nitrate, organic N (ON), a fraction of organic matter, could sustain the primary productivity due to its very fast regeneration by micro-heterotrophs. Hence, the DYNAMITE project will focus on the agricultural impact on the biogeochemical cycle of organic matter from land to ocean given that: (i) agricultural activities are obviously one of the major environmental pressures, (ii) the composition of organic matter is still poorly characterized and (iii) its behaviour in aquatic system is far to be understood. Thus DYNAMITE requires the following tasks: (1) to characterize the fine composition of riverine and estuarine OM considering the whole OM by transferring a water treatment technology in the field of marine chemistry, (2) to quantify the spatial and temporal release of OM from agricultural activities and relate the OM changes to specific land-use, (3) and to determine the dynamics of OM through temperate estuaries under strong agricultural activities and quantify the flux of OM and ON from the river to the ocean. DYNAMITE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering vasoactive probes for brain-wide imaging of molecular signaling' (AVATar).

assistant: **Innovation**

Brain function depends on spatiotemporally defined brain-wide signaling via molecules such as neurotransmitters. No current technology can measure signaling molecules throughout the brain with sufficient spatial and temporal resolution in living mammals. This poses a major roadblock for understanding how molecular neuronal communication coordinates whole-brain function.Magnetic resonance imaging (MRI) currently provides the highest brain-wide resolution. Dynamic imaging of blood flow and oxygenation in the finely arborized vasculature, so-called functional MRI (fMRI), is the only method that can visualize whole-brain function in mammals and humans. However, MRI is inherently insensitive, which precludes it from accessing molecular signaling that occurs at (sub)micromolar concentrations and fMRI cannot resolve neurotransmitter signaling underlying measured hemodynamic signals.I previously designed protein-based vasoactive sensors, named AVATar, that directly cause hemodynamic signals in fMRI in response to target molecules at low nanomolar doses, without using radioactive or metallic components. They can be genetically encoded and also pave the way for noninvasive brain delivery through the vasculature, critical for translational applications in primates and humans.Here, I will combine my expertise in synthetic biology and in vivo molecular imaging to develop my proof-of-concept work into a robust preclinical neuroimaging method along three objectives:1) Engineering AVATars that convert neurotransmitter signaling into hemodynamic signals.2) Brain delivery via non-invasive routes.3) Application for fMRI of brain-wide neurotransmitter signaling in rodents.My project will provide neurotransmitter-sensing AVATars to turn fMRI into molecular fMRI and bridge the long-standing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTIMEDIA INTERACTION WITH REGIONAL AND TRANSNATIONAL ORGANISATIONS' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

MIRTO will study how to improve the effectiveness and efficiency of interactions between authorities, enterprises and individual citizens through the development of multimedia telematics applications for advanced information and transaction services. Applications will be packaged using information held by the public authorities and then marketed and delivered via centres serving end-users in the above groups. Besides clarifying legal aspects of information and services brokering in the Member States, MIRTO will also provide an operational model for companies working in this area.The aim of the project MIRTO is to define and experiment a new way of interaction between Public Administrations, Citizens, SMEs and Professionals of European metropolitan areas. The objective will be reached through the development , evaluation, test, and pilot of multimedia telematics applications for the delivery of added-value information and transactional services, and the setting-up of demonstrators of these applications in four experimental sites: Brussels, Madrid, Marseille, Rome. The services will be packaged using information taken from the information processing systems of the Public Authority Bodies (the Content Providers), while packaging, marketing, and delivery of the services will be handled by Service Centres that may be run by Information and Services Brokering Companies, created using both public and private capital, or by the local administrations themselves. The Users of the Service Centres will be end-users, i.e. Citizens and SMEs, the Content Providers, and Value-Added Information and Services Resellers. MIRTO will experiment, evaluate test, and pilot interconnection among SC's and Content Providers both at a regional and national level through metropolitan and national co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multifunctional encoding system for assessment of movable cultural heritage' in the context of a Sixth Framework call.

assistant: **Objectives**

Nowadays safety, ethical, economical, security issues and the increase demand of loaning for exhibitions in transit, are forcing the Conservation Community to undertake strong initiatives against various types of mistreatment, damage or fraud, during transportation of movable artworks. Therefore the project targets to the development of innovative methodologies and instrumentation to respond to these aspects of increased preservation importance, among which to secure proper treatment, to assess probable damage and to fight fraud actions in transportation.It aims to develop a novel Impact Assessment Procedure by exploiting and providing the holographic technology advances and innovative tools for a highly secure encoding-decoding system of objects features required for sustainable preservation of movable artworks. It may apply in many functional and strategic decision-making aspects in museums operation, from routine seasonal examination of conservation state, to periodic assessment of conservation treatments and materials compatibility, to deterioration control and definition of early-induced damage, to continuous monitoring of transportation impact, to direct confirmation of originality and control of maintenance for any art object in transit.The effective proposed method relies on the original coded extraction of distinct features from the artwork under conservation, transportation and loan that characterizes the state of conservation and its originality. The coding and decoding of characteristic features is performed holographically before and after have been optically and numerically transformed for digital archiving. The archived coded data forming the signatures of the object can be compared at any later time to provide indication of alterations. The project advan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spatial and Temporal Dynamics of the Notch Ligand Delta During Development in Drosophila Melagonaster' in the context of a Seventh Framework call.

assistant: **Objectives**

The Notch (N) pathway is a highly conserved and ubiquitous signalling system involved in determining cell fate. There is a medical relevance to understand the molecular mechanisms involved in N signalling as N dysfunction is linked to cancer, stroke and Alzheimer’s disease. N is activated by its ligands (Delta/Serrate/LAG2;DSL) expressed on adjacent cells and there is a clear correlation between ubiquitination and endocytosis for effective ligand signalling. Although several models for DSL ligand endocytosis have been identified, the behaviour of DSL ligands during these events remains unclear. Attempts to address this issue have lacked the ability to follow spatial and temporal movement of DSL ligands accurately. The current project will therefore address these issues by using live fluorescent imaging techniques to follow movement of Delta (Dl) ligand, fused to a fluorescent reporter, in the wing imaginal disc of Drosophila Melagonaster. This will be achieved by examining Dl molecules present in large intracellular vesicles throughout the wing disc where the ubiquitin ligases Neuralized and Mindbomb1 are expressed. To establish whether Dl activity is dynamic in these particles, we will utilise the FRAP imaging technique. We will follow the movement of Dl molecules from these particles, using a photoswitchable reporter to address the model of “recycling”, where DSL ligands are processed into an active state within these vesicles before being trafficked back to the cell surface to activate N. The effects of impairing endocytosis upon Dl movement from these particles will also be addressed. The project will also address the importance of endocytosis/recycling for effective Dl/N signalling via utilisation of a fluorescent N reporter. These studies will advance our understa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bridging Consumers, Brands and Bio Based Industry to improve the market of sustainable bio-based products' in the context of a Horizon 2020 call.

assistant: **Objectives**

BIOBRIDGES is a 28 months action aiming at boosting the marketability of bio-based products - BBPs by establishing close cooperation and partnership between bio-based Industries - BBI, brand owners and consumers’ representatives. The ultimate goal is to stimulate and support the active engagement of and interaction among all stakeholders (including local communities and local authorities) and improve market acceptance of BBPs.BIOBRIDGES will design and implement replicable methodologies, procedures and good practices supporting multi-stakeholders’ interaction, leading to new cross-sector partnerships. Main activities will be: • Identify the cooperation challenges among consumers, brand owners and BBI • Create a sustainable multi-stakeholder community involving consumer representatives, BBI and brand owners from different bio-based economy clusters and stimulate dialogue and cooperation• Following a co-creation approach, increase consumers’ and brand owners’ awareness, confidence and trust on the benefits of BBPs compared to the fossil-based counterparts, • Support the establishment of at least 2 new cross-cutting interconnections in bio-based economy clusters and define replicable procedures and good practices leading to the establishment of new cross-sector partnerships and business opportunities • Stimulate the multi-stakeholder discussion toward pre-and co-normative research, new standardisation/labelling and emerging co-creation models (B2B and B2C).At the end of the project, at least 2 new cross-sector interconnections in bio-based economy cluster will be established, while the foundations for the creation of new ones based on the arguments, best practices and recommendations deriving from the project will be formed.The BIOBRIDGES consortium merges a variety of com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interactions in Three-dimensional (3D) in vitro environments of Nanoparticles and Cells' (3D) under Seventh Framework.

assistant: **Objectives**

The applications for nanoparticles (NPs) in medicine have rapidly increased in recent years; some examples are drug delivery, medical imaging, in vitro biosensors and cancer treatment. Typically, the biological assessment of NPs is carried out first in vitro (in a 2D petri dish) and then in small animals in vivo (3D). This whole process is costly and time consuming; similarly to that is required for the drug development, 11-15 years and $500 to $800 million to reach the market. An intermediate step between (2D) in vitro and (3D) in vivo assays could provide relevant information, decreasing the total cost of the biological assessment. 3D in vitro assays mimic biologically relevant tissues in an economical and rapid manner; although, current 3D in vitro methods entail complex engineering steps. 3DinvitroNPC focuses on a simple and innovative strategy to create 3D in vitro cell cultures using sheets of porous materials and embedding living cells and NPs within those materials. 3D cell cultures require a material non-toxic for cells and highly porous to allow cells to grow within its microstructure. This project explores aerogels of biomaterials to create 3D in vitro novel scaffolds that are biodegradable and transparent. Combinations of cells and NPs in the 3D in vitro constructs permits the assessment of viability and functionality of NPs in relevant biological environments which is critical for using NPs in medical applications. Gold NPs and FexOy-NPs will be assessed, the first as model NPs and the latter as magnetic label of cells. FexOy-NPs internalized by cells, magnetically label the cells. Localization of magnetic cells using a magnet placed outside the body is a recently developed medical method non-invasive for tissue recovery after cerebral ischemia. For this pu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'PHASE COHERENT DYNAMICS of HYBRID NANOSTRUCTURES'.

assistant: **Concept**

The theoretical work outlined in this proposal will focus on generic phenomena in nano-scale superconducting, semiconducting and magnetic such as recursive Green's function techniques, random matrix theory and hybrids. Studies of phase coherent Andreev scattering in transfer matrix methods. These are core techniques and by becoming familiar superconductor-2DEG and superconductor-ferromagnet hybrids will encompass with them, the young researchers in this project will acquire a range of resonant transport, level statistics, the role of non-local pairing, order transferable skills. This proposal will place a postdoctoral researcher into each of eight teams. By organizing and participating in Summer Schools parameter dynamics and time dependent transport. Studies of interaction and workshops, each team has established a track record for the training of effects will examine the role of electron-electron and electron- phonon interactions in quantum dots. young scientists. The network will form part of a Euroconference proposal and a Network of Excellence in mesoscopic superconductivity. Annual network meetings will give young researchers an Opportunity to improve presentational skills and exchange ideas. Each postdoctoral researcher will spend of order one month per year visiting other institutions in the network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Scaling Up Biostimulant Technology for Agriculture Resilient to Climate change' (SUBTARC) under Horizon Europe.

assistant: **Objectives**

Today, drought and salinity constitute two of the most severe threats to global food security, and are rapidly increasing as climatechanges progress. These stresses have a high impact on plant’s ability to use nutrients, resulting in a significant reduction in cropyields. Accordingly, ca. €90 B/year are lost due to salinity and drought, representing 800+ M ha of arable land affected globally only by salinity. To tackle this clear socio-economic problem, new, sustainable solutions are urgently needed. Players in BioAgriculture have been developing a new class of solutions termed biostimulants, i.e., substances or microorganisms stimulating plant response, which improves its utilization of nutrients and tolerance to abiotic stresses. Despite such solutions already exist on the market, they typically rely on the application of large doses, rendering the solutions expensive and difficult to implement in existing agronomic practices. To address this market gap, Agrobiomics is developing a new biostimulant solution produced by bacterial fermentation, which effectively tackles the limitations of existing solutions. Agrobiomics’ solution presents an unseen potency on stimulating a sound plant’s response to drought and salinity, requiring thus very low dosages. With the solution validated for different types of broadacre and Fruits & Vegetables crops, Agrobiomics now aims to optimize and scale-up the production and demonstrate the efficacy of its solution in large field trials, essential to develop the regulatory package needed for approval and to convince end-users and big BioAg companies about the robustness of the technology. These activities will be key to unlock the commercialization of this new product. Therefore, the EIC-A support is critical to co-finance the final techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization of Structural Behaviour for High Frequency Phenomena' (CRASHING).

assistant: **Innovation**

The use of composite materials as principal structural elements in an aircraft requires the complete understanding of their mechanical properties. In particular, when structure is subjected to high frequency loading conditions (i.e. low and high energy impacts) phenomena as wave propagation, strain rate dependences, delaminations and rupture need to be fully understood. This is crucial to obtain certification of aeronautical structures like those proposed within the “Clean Sky - Green Regional Aircraft” initiative.Current numerical models are based on tests and technologies developed during the nineties in European R&T Programs. Since then, significant progress has been achieved in the development of physically-based models and multiscale modelling strategies, which provide more accurate results and can be applied to different materials. In the CRASHING project, the state-of-the-art in multiscale simulation of composites will be transferred to the current numerical tools used by the industry in the simulation of the mechanical behaviour of composite structures for aerospace applications. The project will be focused in composite materials currently used in aircraft innovative designs. In addition, new materials with potential application in the future will be assessed with respect to the database generated along the project.The objective of CRASHING project is to develop multi-scale model approach that takes into account the physical mechanisms of damage at the different length scales so the influence of the microstructure and loading conditions can be taken into account rigorously. The multiscale approach describes systematically the material behaviour at different length scales from ply, laminate to component levels. Final models of the multi-scale approach will be sui