RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Neural and Network Dynamics of Social Influence Across Adolescence' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Peer influence has long been established as one of the most important factors in almost all aspects of adolescent development and behavior, including academic achievement, prosocial behavior and risk-taking. More recently, peer influence seems to be amplified by developments in social media (e.g. viral risk-taking challenges). However, surprisingly little is known about the mechanisms underlying peer influence, or why adolescents are specifically sensitivity. The primary goal of this proposal is to gain insights in the role of social information in adolescent behavior, by developing a new theoretical framework that will be formalized in novel computational models. First, in contrast with previous accounts, adolescents are not treated as the passive receivers of social information, but considered as agents that play an active role in searching for social information. This search revolves around two main questions: when to search for social information, and who to learn from. To track development in social learning strategies I will develop novel tasks to investigate (1) when, and how much, social information is searched for, and (2) who adolescents will go to. Second, I will employ computational models in combination with functional magnetic imaging to gain insight in how brain development, and pubertal hormones are associated with changes in specific computational processes that are involved in social learning. Thirdly, social learning will for the first time be studied experimentally in real peer social networks. Social network analyses will be used to elucidate the impact of different types of peers, and to study the diffusion of information through peer groups. Our findings will significantly advance our understanding of the mechanisms of social learning in the conte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Common mechanisms and pathways in Stroke and Alzheimer's disease.' in the context of a Horizon 2020 call.

assistant: **Objectives**

Common mechanisms and pathways in Stroke and Alzheimer's disease.It has long been recognized that stroke and (Alzheimer’s Disease) AD often co-occur and have an overlapping pathogenesis. As such, these two diseases are not considered fellow travelers, but rather partners in crime. This multidisciplinary consortium includes epidemiologists, geneticists, radiologists, neurologists with a longstanding track-record on the etiology of stroke and AD.This project aims to improve our understanding of the co-occurrence of stroke and AD. An essential concept of our proposal is that stroke and AD are sequential diseases that have overlapping pathyphysiological mechanisms in addition to shared risk factors. We will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge into causing either stroke, or AD, or both. Another important concept is that mechanisms under study will not only include the known pathways of ischemic vasculopathy and CAA, but we will explore and unravel novel mechanisms linking stroke and AD. We will do so by exploiting our vast international network in order to link various big datasets and by incorporating novel analytical strategies with emerging technologies in the field of genomics, metabolomics, and brain MR-imaging.


**Keywords:** Stroke, Alzheimer's disease, genomics, metabolomics, brain imaging, common mechanisms, pathophysiology, prediction, therapeutics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sensors for LArge scale HydrodynaMic Imaging of ocean floor' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

LAkHsMI will develop a new bio-inspired technology to make continuous and cost-effective measurements of the near-field, large-scale hydrodynamic situation, for environmental monitoring in cabled ocean observatories, marine renewable energy and port/harbor security. We will design, manufacture, and field test prototype smart sensor cables that measure differential pressure and temperature on the ocean floor and enable high resolution imaging of the surrounding volume in space and time, is simple, inexpensive and has very low power consumption The cables can be connecting with existing cabled ocean observatories. The technology is inspired by the biophysics of fish hydrodynamic sensing. The technology is scalable from meters to possibly hundreds of kilometers and allows a high sampling frequency. LAkHsMI will also develop innovative methods for hydrodynamic imaging. It produces several continuous on-line information products for interdisciplinary oceanography and seismic geophysics but also for other applications including tracking fish and fish schools or (sub)surface traffic in harbours. Software interfaces developed in the course of the project will be integrated with existing observatory systems (such as EUROGOOS). LAkHsMI will design and implement the sensor cables on small large scales. Tests will be conducted in a tank, a pool, an in ocean observatory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart video for smart devices' under Horizon 2020.

assistant: **Concept**

The popularity of touch screen devices for viewing video opens new opportunities for TV broadcasters, publishers and media companies to engage, measure and monetise viewers. Interacting with the video provides a fun viewing experience and increases viewing session time, which in turn gives video channels commerce opportunities worth hundreds of millions. However, broadcasters and video content owners lack the knowledge, resources and technologies to create such interactive experiences.Irish SME, Axonista, develops technologies that allow all media companies to deliver interactive experiences to their audience. Axonista’s award-winning Ediflo is the complete platform for creating, managing and distributing a new generation of video-based interactive digital experiences. Ediflo contains all the necessary tools for developing interactive video apps for smart devices running on all major platforms. Building the apps is made simple and fast, with very little friction in setting up an interactive video service.Axonista has already delivered nearly 40 apps to well-known large TV broadcasters and video start-ups in Europe and the US. These apps have provided measurable benefits to Axonista clients, leading to numerous new orders.The funding for this project will facilitate building a product called Ediflo Pro – based on the validated Ediflo technology – which will enable customers to launch new video apps in a matter of hours. Axonista will build analytics tools that enable broadcasters to make fact-based decisions about their programmes. The EDIFLO PRO project supports the implementation of a new product sales business model to enable global scale-up of Axonista activities.As a result of the project, Axonista will have a product that can be sold via an annual subscription mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European project on stratospheric processes and their impact on climate and the environment' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Problems to be solvedEuroSPICE is centred on investigating the impact of the Montreal and Kyoto protocols on the atmosphere. Research on chemistry-climate coupling has suggested that control of both future greenhouse gas emissions and halogen concentrations is necessary to avoid future severe ozone loss. However, the likely level of future ozone depletion is uncertain due to the fact that previous studies have not represented all the known processes. In this project detailed simulations are carried out to help understand past stratospheric trends and to predict future temperature, ozone and surface ultraviolet amounts.Scientific objectives and approachThe trends in ozone, surface ultraviolet and temperature determined from observations are updated for the period 1980-2000. Trends in these quantities are then simulated using a range of numerical models of the atmosphere, varying from simpler models to very detailed models. These simulations are then extended to the year 2020 with a particular emphasis on the prospect for severe ozone depletion in northern high latitudes and its possible impact on Europe. The results are analysed to determine the likely causes of past stratospheric trends. The results are investigated to understand more clearly the impact of stratospheric change on tropospheric climate and photochemistry.Expected impactsWith improved simulations of past stratospheric changes we have more confidence in the ability of numerical models to predict future changes. These predictions of the future ozone levels have an important impact on the future health and well being of the European citizen because of the connection with surface ultraviolet amounts. Also, the results give improved understanding the atmospheric climate system and in particular whether a detail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering Split Monopoiesis Impact on Tissue Macrophages' under Horizon Europe.

assistant: **Concept**

Macrophages are key players in organ development, tissue maintenance, and the immune defense of vertebrate organisms. These cells are initially established during embryonic development, but most tissue-resident macrophage compartments are progressively seeded and often even replaced by monocyte-derived cells. Monocytes and their macrophage progeny critically contribute to a wide range of pathologies, including autoinflammatory, cardiovascular, and metabolic disorders, as well as cancer. Given their central role in physiology and pathophysiology, these cells are attractive targets for therapeutic intervention. This will, however, require an in-depth understanding of monocyte-to-macrophage trajectories, whose comprehensive study in mice and man is the goal of this proposal.Beyond these translational implications, our studies are particularly well-timed, given new exciting findings: thus, monocytes were recently shown to arise from distinct developmental trajectories, and we discovered that this developmental monocyte dichotomy translates into tissue macrophage heterogeneity with probable significant functional impact. Here, we propose to follow up on our recent intriguing finding and use murine fate mapping and novel Csf1r-targeted genetic perturbations, combined with a high-resolution single-cell-based imaging and omics analysis of murine and human blood, to explore the impact of developmental monocyte dichotomy on health and disease in man and mice. An in-depth understanding of the two monocyte trajectories, their differential dominance following infections, and differential fates in distinct tissues will have significant value for the future development of strategies for tissue macrophage manipulation. Moreover, our detailed analysis of human blood might incentivize ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'How anxiety transforms human cognition: an Affective Neuroscience perspective', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Anxiety, a state of apprehension or fear, may provoke cognitive or behavioural disorders and eventually lead to serious medical illnesses. The high prevalence of anxiety disorders in our society sharply contrasts with the lack of clear factual knowledge about the corresponding brain mechanisms at the origin of this profound change in the appraisal of the environment. Little is known about how the psychopathological state of anxiety ultimately turns to a medical condition. The core of this proposal is to gain insight in the neural underpinnings of anxiety and disorders related to anxiety using modern human brain-imaging such as scalp EEG and fMRI. I propose to enlighten how anxiety transforms and shapes human cognition and what the neural correlates and time-course of this modulatory effect are. The primary innovation of this project is the systematic use scalp EEG and fMRI in human participants to better understand the neural mechanisms by which anxiety profoundly influences specific  cognitive functions, in particular selective attention and decision-making. The goal of this proposal is to precisely determine the exact timing (using scalp EEG), location, size and extent (using fMRI) of anxiety-related modulations on selective attention and decision-making in the human brain. Here I propose to focus on these two specific processes, because they are likely to reveal selective effects of anxiety on human cognition and can thus serve as powerful models to better figure out how anxiety operates in the human brain. Another important aspect of this project is the fact I envision to help bridge the gap in Health Psychology between fundamental research and clinical practice by proposing alternative revalidation strategies for human adult subjects affected by anxiety-related dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Oxidation and EPItaxy pre CLEan treatments'.

assistant: **Objectives**

Assessment of a 300 mm prototype equipment for the manufacture of semiconductor components. The equipment is a compact size, wet process, single tank reactor, dedicated to the pre-clean steps of advanced front-end CMOS processes (<0.15 µm), e.g., composite gate oxide growth and low temperature epitaxy and hetero-epitaxy. The assessment will cover manufacturing relevant parameters such as throughput, CoO and liquid consumption reduction. It will also evaluate the concept of diluted chemistries for both chemicals consumption reduction and minimum unwanted surface state modification prior to the following process step. Thanks to a coupling with another 300 mm single wafer cluster which benefits of in-line optical characterisation tools, the process parameters of the pre-clean steps will be linked to those of two fundamental steps of the front-end CMOS process: oxidation/nitridation/annealing and low temperature Si and SiGe alloys epitaxy and hetero-epitaxy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced kinematics for manufacturing applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main developments of this project were made in the following PKM areas:- Definition and evaluation of possible and already realised applications- Development of a PKM configuration tool, to evaluate workspace, stiffness a.s.o.- Development of a CAM tool for PKMs for post-processing, singularity handling a.s.o.- Testing of existing and development of joints for PKM applications- Evaluation and development of new actuators- Development of measurement tools and calibration strategies- Evaluation of suitable testparts and benchmark strategies.Multi-functional, flexible but cost-effective production equipment is becoming more and more important to cover market turbulence. In order to realise a fast and flexible single-hit production process, robots have already achieved a considerable degree of acceptance. Most of them are based on multi-axis structures, where individual rotary and linear axis are connected in a serial way. Their main advantage is their dexterity, thus allowing for a large nurnber of different applications, where repeatability is more important than the absolute positioning accuracy of a given end-effector. If higher accuracy is needed, machine tools are used which are based on the perpendicular composition of three linear axis. The main reason for this arrangement is the ease of applying the simple Cartesian co-ordination system to control spatial movements. Additional linear and/or rotational axis may be integrated to extend the machine tool's geometrical capability. They are also combined in a series of discrete stages, each one providing a single degree of freedom. A different approach is followed by parallel kinematics architectures which principally combine the advantages of both robots and machine tools. This basic research project proposal forms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Land use policies and sustainable development in developing Countries' in the context of a Sixth Framework call.

assistant: **Objectives**

The proposed project will develop integrated assessment tools for sustainable development for application by scientists in a selected number of developing countries. Attention will be given to both natural and agricultural ecosystems. The project provides assessment procedures that enable documentation and understanding on impacts of land use policies on sustainable development, taking into account multi-functionalities and European policy options on biodiversity, climate and trade. More, specifically, the project will include the following actions: - Design of an analytical framework to assess the impact of land use policies on the sustainable development of developing countries;- Identify the key driving forces for the utilization of land and their impacts on sustainable development and externalities;- Tools developed in SENSOR and SEAMLESS will be used both as building blocks in and guidelines for this project;- Select, adapt and apply tools for understanding, planning and forecasting the impacts of land use policies. Their generic nature will be assessed. Multifunctional land use and European and developing country policy options are taken into consideration. Links between competitiveness, global agreements and land use in the EU will be analysed;- Define indicators and explore their thresholds in the context of sustainable development. This will be done at regional and national levels. The analysis will include multiple sectors and attention will be given to biodiversity, supply of public goods and services;- Enhance existing knowledge in the field of data management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Basis of Toxoplasma gondii Encystation and Persistence' (ToxoPersist), addressing dissemination and exploitation.

assistant: **Impact**

Toxoplasma gondii is the most successful obligate intracellular parasites infecting virtually all warm-blooded animals. A infection initiates with the dissemination of the fast-replicating tachyzoites. At the onset of the immune response tachyzoites convert into slow-growing bradyzoites that form cysts in the central nervous system and in striated and heart muscles. Encystation ensures life-long persistence and poses a significant threat of reactivation during immunosuppression and can lead to encephalitis and severe clinical manifestations. Despite the importance of encystation for pathogenesis and transmission, our insight into how T. gondii defies the immune responses to take up permanent residence in the immunocompetent hosts is rudimentary. We propose to determine the molecular mechanisms governing cyst wall formation and parasite adaption to encystation. We will capitalize on the increased sensitivity of -omics approaches, the power of the CRISPR/Cas9 genome editing, the high-resolution microscopy, and on the ex-vivo tissue examination by MALDI imaging mass spectrometry and NanoSIMS technologies.The specific objectives are to: 1. Identify the components of the Cyst Wall (CW), Parasitophorous Vacuole (PV) and PMV Membrane (PVM) of the cyst2. Determine the parasite factors responsible for CW formation and maturation via targeted and unbiased approaches3. Define the metabolic network of parasite that is able to initiate encystation and ensure persistence 4. Measure subversion of host metabolic functions by parasite effectors during encystation and persistenceWe anticipate fundamental discoveries on i) the regulatory and trafficking circuits that govern CW formation as a biological barrier during encystation ii) metabolic adaptation and subversion of host cellular fun