RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Diamond forming fluids: a window to diamond chronology and deep Earth volatiles.' in the context of a Sixth Framework call.

assistant: **Objectives**

Diamonds provide us with pristine samples of the deepest derived solid and fluid material that we can sample from the interior of the Earth. Inclusions in diamonds have been in isolation since their entrapment and allow a glimpse to the depths of the mantl e and far back in time. Diamond ages, inferred from dating mineral inclusions trapped within, are subject to some uncertainty due the precise nature of the relationship between the solid inclusion and the diamond. Most diamonds grow from fluids. Direct dat ing of these parental fluids removes any genetic ambiguity that affects the dating of solid inclusions. In addition, knowing the age of the fluid allows us to track temporal changes in deep Earth fluids. The growth structure of fibrous diamonds is conduciv e to trapping diamond-forming fluid micro-inclusions in great abundance. These diamonds enable, for the first time, direct dating of the diamond itself. I propose to date fluid-rich diamonds to compare their age, isotopic and trace element composition. The data will be compared with that of other diamonds and with the ages and isotopic composition of the host kimberlites. Their isotopic compositions will be used to constrain the origin of diamond-forming fluids. The results will bear on the role of the dia mond-forming fluids found in fibrous diamonds to the formation of most other diamonds, including gem diamonds. The results will enable evaluation of the idea that kimberlites and diamond forming fluids evolve from a similar parental melt and will be import ant for understanding the origin, roll and composition of volatile rich fluids in the mantle, in the context of bulk Earth volatile budgets. The applicant will bring skills in micro- and nano-analysis techniques and will be trained in the latest ultra-low leve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative micro-abrasive Water Jet for high precision machining and finishing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Founded in Legnano (Italy), in 1940, our company Vito Rimoldi S.p.A. is one of the leaders in manufacturing of gaskets for industrial applications (e.g. for aluminium radiators, compressors). Since the very beginning our policy has been to distinguish ourselves by providing the international market with new and high quality products fitting the most advanced applications. To do so, through successful collaborations with industrial leaders and university centres, we have pursued our aim for excellence, increasing our know-how and technical competences. This allows us to have a team of experts to assist our customers with their new challenging projects and identify and enter new value niche markets to increase our turnover (€7.0M in 2013).Vito Rimoldi has been continuously challenging the current State-of-the-Art in terms of high-precision cutting of materials, both soft (rubber, plastic) and hard (carbon fibre, tungsten, quartz, titanium, ceramic). Over the years, we have acquired a leadership position in Water Jet technology.Our NEWERA project will provide the industry with a solution to the challenge of machining small parts (<1mm) that require a high degree of accuracy (<10μm), tolerance (± 10μm) and finishing (Ra<1μm)Based on a new Micro-Abrasive Water Jet system, NEWERA will allow high precision, finishing and control, and therefore enter niche markets for high precision mechanics, electronics, biomedical, automotive and high finishing of fashionable/luxury items (e.g. watches, jewellery), thus subsequently increasing our sales by 40% within 5 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'From the magnetized diffuse interstellar medium to the stars'.

assistant: **Objectives**

Understanding star formation remains one of the greatest challenges of modern astronomy. Indeed in this field the progresses have been limited due, first, to the huge dynamics of spatial and temporal relevant scales and, second, the great variety and non-linearity of the physical processes involved in the formation of stars. The present proposal will contribute to provide a complete and coherent picture of the star formation process by self-consistently following the evolution of the interstellar matter from the very diffuse gas up to the protostars. This will be achieved by performing a series of heavy MHD numerical simulations with an adaptive mesh refinement code while subdivising the problem in three major steps namely the formation of large scale molecular clouds, the formation of star forming cores and the collapse of protostellar cores. In particular, the impact of the magnetic field and the radiative processes will be self-consistently treated using appropriate schemes. At each step, comparisons with both analytical models and observations will be performed by using existing models or developing new ones and calculating synthetic observations. The simulation results will also be used to test and improve the methods and the algorithms used by observers to extract the physical information from their data. An existing database, where the simulation results are available, will be further developed. The present proposal pursues two aims: i) achieving a global understanding of the star formation process, in particular by elucidating the link between the physical properties of the large scale ISM and the characteristics of the protostars, such as their mass, magnetisation and angular momentum ii) provide a better insight of the structure, nature and role of the magneti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RNA EDITING IN HEALTH AND DISEASE', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

RNA editing is a type of programmed RNA sequence alteration that can result in a range of proteomic changes, from subtle fluctuations in output, to specific alterations in protein content. Editing is catalyzed by two classes of deaminases: those which convert adenosine to inosine (ADARs) and those which convert cytosine to uracil (APOBEC1). We have previously shown that APOBEC1-catalyzed editing in the transcriptome of macrophages leads to the generation of populations that are heterogeneous, and functionally diverse, enabling rapid population adaptation to different environmental settings. Our first aim for this proposal is to extend our studies to additional immune cell subsets, focusing on cells that are recently recognized as ""plastic"" to define the contribution of editing to this plasticity of fate and function.RNA editing of the type we study has also been demonstrated to be crucial for cancer progression. For instance, APOBEC1-deficiency significantly reduces tumour burden on cells of the intestine and colon that are prone to adenocarcinomas in the context of the APC-min mutation. This is also the case for testicular carcinomas in mouse models of such tumours. Thus, there is genetic evidence for a requirement for APOBEC1 and RNA editing to drive tumour progression, in two tumour contexts. Based on these data and on our recently deciphered role for APOBEC1 as a ""stealthy"" diversifier of cellular transcriptomes (and proteomic outcomes),  we hypothesize that APOBEC1 drives tumour progression by editing select transcripts in tumour cells (or tumour stem cells), thus enabling the rapid adaptation of the tumour to the onslaught of the immune response. Our second aim is to characterize the subset of edited transcripts in these model tumours (either at the population
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The critical role of sedimentary trace element fluxes in ocean biogeochemistry'.

assistant: **Concept**

Trace elements and isotopes (TEIs) are powerful tools for studying the ocean system and tracing its interaction with the other Earth System components. Many TEIs exert influence on the surface environment by participating in the global carbon and oxygen cycles. Incorporating TEIs into state-of-the-art global models is thus crucial to better predict future changes of ocean biogeochemistry and climate. This effort, however, is hampered by our limited understanding of the source and sink fluxes of TEIs across the sediment-water interface, which are recently hypothesised to play much greater roles in setting the distributions of TEIs in the ocean than previously assumed. Yet insufficient knowledge results in large uncertainties in model implementations of sedimentary fluxes, severely limiting the applications of marine TEIs. The objectives of SedTraceFlux are to constrain the sedimentary TEI fluxes and provide robust parameterizations of such fluxes suitable for global models. This project will focus on iron, neodymium, zinc and their respective isotopes, which are among the most useful TEI tools in oceanography. I will model the chemical speciation and the processes controlling the distributions of these TEIs in sediment pore water and solid phases. The resulting mechanistic parameterizations of sedimentary fluxes will be fine-tuned using Transport Matrix Methods in global biogeochemical modelling. The modelling effort will be complemented by generation of sedimentary Fe data from under-sampled locations. This project represents an ideal synergy between my ability in geochemical modelling and sediment geochemistry, and the expertise of the host group in a broad range of chemical, isotopic and global modelling approaches. It will enhance my innovative potential toward an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Costing the impact of demersal fishing on marine ecosystem processes and biodiversity' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project addresses the conflicting EU objectives of maintaining sustainable fisheries in European waters with all the economic benefits afforded to the community through the fishing industry, whilst at the same time maintaining biodiversity and avoiding negative effects on the environment.COST-IMPACT aims to put an economic valuation or costing on marine ecosystem resources or goods and services and indicate how this value is affected by fishing. This will provide fisheries and coastal zone managers with an effective tool to determine their policies.The primary objectives are to provide advice to decision makers on:1.) How demersal fishing impacts the biodiversity of marine benthos and the associated goods and services, such as nutrient cycling that they provide2.) How these impacts influence other marine ecosystem processes and then3.) What the likely values of marine ecosystem goods and services are and how these values are affected by fishing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Infinite graphs, ends, their topology, and totally disconnected groups' in the context of a Sixth Framework call.

assistant: **Objectives**

We build a new axiomatic end theory for non-locally compact spaces (such as non-locally finite graphs) as a generalization of Freudenthal's end theory. A theorem of Hopf which determines the structure of the end space by groups acting with small" fundamental domains shall be generalized and extended. We deal with questions concerning the cycle spaces of graphs which link combinatorial graph theory and end theory. Furthermore, we compare directions of the action of totally disconnected topological groups on rough Cayley graphs with directions of these groups which were defined purely algebraically by Baumgartner and Willis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Monitoring innate immunity in arthritis and mucosal inflammation'.

assistant: **Innovation**

In chronic joint disease, only a subgroup of patients has classical autoantibodies, while the other variants are seronegative arthritis syndromes with a predominance of innate immune disturbances. These forms of joint diseases frequently show extra-articular manifestations of epithelial tissues like skin and gut. On the molecular level, innate immune activation and the release of damage associated molecular pattern proteins (DAMPs) of the S100 family are important mechanisms of initiation and perpetuation. Early diagnosis remains a significant problem, and prediction of disease extension and course is challenging. Despite all efforts we do not have therapies that alleviate the disease and protect from disease progression, damage and long-term disability. The identification of specific inflammatory mechanisms that correlate to patterns of disease characteristics would allow targeted therapeutic approaches. In a comprehensive research approach, MIAMI will establish relevant disease mechanisms and translate finding into novel biomarkers for individual adaptation of therapies (personalised medicine) for seronegative arthritis. Our research strategy leaves retracted ways of genetics and classical autoimmunity; instead we will focus on innate immunity and inflammation. The goals of MIAMI are ambitious and will be reached with cutting-edge research performed by the most excellent researchers in the field, who have been combined to form a multidisciplinary consortium. The choice of the scientific as well as industry partners was entirely based on excellence. Thus, MIAMI brings together the leading teams that are working on mechanisms of innate immunity in arthritis and mucosal inflammation. In summary, MIAMI will significantly contribute to progress on the key questions: Who wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analysis of interactions between cell division proteins' (CELLDIV), addressing dissemination and exploitation.

assistant: **Impact**

Cell division is a fundamental process that allows the multiplication of all bacteria. Although this mechanism is essential for their survival, it is one of the least understood processes in bacterial cell biology. Understanding the molecular function of different factors implicated in this key event of the bacterial cell cycle is essential. Furthermore the characterization of cell division machinery will open up new opportunities in bioengineering and development of novel therapeutic and antibacterial agents.During the past ten years, genetic approaches as well as major improvements in cytological and immunofluorescence techniques generated a wealth of data on the localization and recruitment of cell division proteins to the septum. However, specific protein interactions and complex formation have not been studied in great detail. This research project is directed at elucidating the interactions and communication between cell division proteins in Gram-negative bacteria, thus initiating a new dimension to the study of cell division.The first phase of the project will emphasize the use of biochemistry to define direct interactions between proteins assembled at the septum and to identify and characterize new cell division components. During the second phase, a n innovative and powerful genetic tool based on bacterial double hybrid system will be developed in order to validate, in an in vivo context, protein interactions and the new partners unveiled by genetic and biochemical approaches. This project will contribute to the development of a competitive high impact field in Europe by significantly extending our knowledge on cell division process and by combining classical and innovative approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Edurio – a revolutionary web platform for school networks to improve the quality of education through deep analytics of stakeholder feedback' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Up to now stakeholder feedback management in school networks has been a very time consuming paper exercise with no central data management possibility and poor analytics. Edurio offers a unique opportunity to remove 95% of time and financial resources, improve survey reliability and use deep analytics to provide users the most important insights and recommendations for smarter decision making.Edurio’s SME Instrument project aims to bring to market a web platform for schools and school networks (governments, municipalities and private networks) to radically improve the way they manage quality of education, by using our unique system with streamlined user flow and novel machine learning analytics.Edurio’s platform allows school networks to regularly collect and analyse feedback surveys from students, parents and teachers. Automatic machine-learning based diagnostics along with deep analytics (student group analysis, advanced text analysis etc.) will give schools and school networks recommendations to set educational priority areas and future actions.Since July 2014 we have developed 3 prototype versions of Edurio and tested them in over 200 schools with 50’000 students and 5’500 teachers, completing 100’000 surveys. The pilots validated the market need and highlighted the requirements we need to meet for an international scale-up. We are collaborating with global leaders in education like the UCL Institute of Education and Oxford University Press and have received interest to conduct international school network pilots, enabled by the H2020 support. We have a uniquely skilled team with experience in strategy, software development, AI and education. With this project, we aim to scale Edurio to school networks internationally containing 30’000 schools in 5 years from market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hydrophobically modified polyelectrolytes - materials for treatment of polluted water' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

An increasing interest for the treatment of raw and waste water by water soluble polymers has developed during the last decade, in which the main role of the polymer is to induce flocculation (aggregation) of the mineral and organic colloids present. However, this treatment is of poor efficiency regarding the elimination of soluble organic micropollutants. The objective of this project is to derive new hydrophobically modified cationic polyelectrolytes which could fill this gap by combining flocculation of the suspended particles and elimination of the organic micropollutants. These materials will be derivatives of poly(vinylbenzylchloride) fully quaternized with tertiary amines of various hydrophobicity. Their structure will range from the typical polyelectrolyte containing only hydrophilic units, to the polysurfactant (in which the repeating unit is surfactant-like). Their properties in dilute and semidilute aqueous solution will be studied and correlated to their hydrophobicity. Special attention will be paid to the relation between polymer chain conformation and solubilization capacity towards organic micropollutants. In a final step their simultaneous efficiency towards silica flocculation and organic micropollutant extraction will be tested.