RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of SOX9-BMI1 in adult neural stem cells and in glioma stem cells'.

assistant: **Innovation**

Cancers display remarkable phenotypical and functional intratumoral heterogeneity. The discovery of a rare subpopulation of tumor cells that acquired stem cells properties in several malignancies has profound implications for cancer therapy. These cells are suppose to be responsible for the origin, progression and recurrence of the tumors. Thus, new strategies directly targeting cancer stem cells should be important for cancer treatment. Glioblastoma multiforme, the most common and malignant brain primary cancer, present very low success rate in the actual therapeutic protocols and the average survival for patients do not exceed a year of life. This can be partially explained because they contain a population of glioma stem cells.Factors involved in establishing and maintaining stem cells of normal tissues are activated as part of the tumorigenic process. It is likely that these stem cell factors are important for providing and maintaining the characteristics of cancer stem cells. SOX9 and BMI1 are transcriptor factors essential in multiple processes during embryonic development and in the regulation of stem cells in various tissues including the brain. Both are often overexpressed in cancer, mainly in tissues where they plays critical roles in stem/progenitor cells. Our group has recently identified that BMI1 is a direct downstream target of SOX9. The goals of this translational research project is investigate the clinical relevance of SOX9-BMI1 in glioblastoma, characterize its role in the regulation of glioma stem cells and determine whether Sox9-Bmi1 concomitant overexpression is sufficient to induce neural stem cell transformation and cause gliomas. To achieve our aims, we will generate a unique set of cellular and animal models to study in vitro and in vivo the bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Circular and Connected Pavements for Carbon-Neutral and Digital Roads' to be submitted under Horizon Europe.

assistant: **Abstract**

Roads are the arteries through which economic and social development pulses, and are one of the most important public services in the world. However, roadway assets are currently made of virgin and fossil-based materials and processes. Additionally, roads are subjected to ever-heavier traffic loads, relentless traffic concentrations and climate change, which will result in much quicker infrastructure failures, and in turn costs. Therefore, the aim of this DN is to create Circular and Connected Pavements for Carbon-Neutral and Digital Roads (CIRCOPAV) through a world-class international, inter-disciplinary and inter-sectorial training programme for ten doctoral candidates. CIRCOPAV DN will complete two key scientific objectives: 1) road network digitalisation to create smart and automated pavements, and 2) pavement sustainability to mitigate carbon footprint and ensure climate change resilience. These targets will be achieved through a consortium of 8 universities, 8 industrial companies and a road administration, across 8 countries and 3 continents, and combine the transportation, construction engineering, sustainability, electronics and data science sectors to create a new generation of creative, entrepreneurial and innovative leaders for the next generation of roads. Additionally, these goals fall directly in line with Horizon Europe’s goal to transition to a green and digital economy, the Green Charter and two Horizon Europe Missions. They will be achieved via intelligent and connected (e.g. sensors and IoT networks) and sustainable technologies (e.g. low emission materials and manufacturing and climate change resilient designs and materials). As a result, guidelines and prototypes will be developed up to TRL 6 and designed for exploitation in Europe and developing c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fully integrated solution to both monitor and control indoor air quality thanks to a network of inbuilt sensors array combined with an AI driven management of the HVAC system' in the context of a Horizon 2020 call.

assistant: **Objectives**

We spend 90% of our time in enclosed environments. Indoor air quality can be up to 5 times more polluted than outside, caused by factors such as the emission of Volatile Organic Compounds (VOCs), Particulate Matter (PM), Carbon Dioxide (CO2), carbon monoxide (CO), Nitrogen dioxide (NO2), ozone (O3), etc. Indoor air management is responsible for 30% to 50% of building energy costs. It is often difficult for facility managers who control ventilation inside buildings to obtain real-time indoor air quality (IAQ) data, and hence resort to overventilation to ensure safe levels of pollutants in their buildings. Current solutions are only solving part of the problem: They process air treatment but they have no feedback loop. Many technologies are available for air purification (e.g. Plasma Air purification, Electrostatic filtration, UV) but they do not provide any air monitoring to assess the quality of the air, thus they are always turned on which result in high energy costs. Some stand-alone air purifiers exist to monitor and control air quality, but the monitoring is very basic, the control of air treatment system very limited and energy consumption remain high. SAB is the first fully integrated solution to both monitor air quality and control air treatment systems thanks to its inbuilt multiple sensors combined with AI driven data processing which 1) reduce up to 50% the HVAC energy cost, 2) Improve the air quality by up to 15% (especially for the parameters PM 1, 2.5 and 10, tVOC, CO2, CO, NO2, O3), 3) improve comfort by fine tuning temperature on a pro-active mode, 4) offer an excellent return on investment (less than 3 years) and reduce maintenance up to 30%. AIRBOXLAB S.A. is a well-established engineering SME created in 2013 with an annual turnover around 3M€ and 16 fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CoFutures: Pathways to Possible Presents' under Horizon 2020.

assistant: **Concept**

This project investigates future fictions from five distinct traditions: Afrofuturism, Sinofuturism, Arab/Gulf-futurism, Latin@futurism, and Indofuturism. All these fictions respond to the burning issues of the present, the transnational discourses of demographic change, climate change, and technological change, but they imagine different, localized ways of engaging with these transnational discourses.Research QuestionsWhat contributions can contemporary future fictions make to our understanding of global issues?The project is split into three sub-questions to structure the enquiry:1. What are the cultural and scientific bases for the development of different geography based future fictions? 2. What are the future changes – societal and technological – imagined in these future fictions?3. How can we understand the response to global challenges – demographic change, climate change and technological change – in the local changes imagined in these futures?Based on this, the project will develop a theory of “COFUTURES” (Co: Complex –Coexisting –Comparative). Context The project studies the recent proliferation of fiction based on ethnic, cultural, or national identity as take-off points for imagining possible futures even if their locations of production are globally spread. While many of these have older histories, these fictions have come together in this decade as alternative visions of the future that are resistant to perceived colonial or neo-colonial hegemony and are read as new forms of self-assertion. No methodologies have been developed to study all these together as shared phenomena, and no theories exist that can even make sense of them as similar yet distinct phenomena. There have also been no attempts to understand the specific sources for these futures in term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mix and Match: One-step activation for targeted drug delivery' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Current clinically approved drug delivery systems, such as liposome, PEGylated liposome, and polymeric micelle, predominantly rely on passive accumulation within tumor tissues by diffusion through the defective tumor vessels during circulation. The targeting efficacy toward cancer cells is very limited due to their inadequate interaction with cancer cells. The attachment of targeting ligands to nanocarriers has demonstrated its effectiveness in enhancing binding affinity and, consequently, facilitating cellular uptake via receptor-mediated endocytosis. However, the conventional methods employed for ligand attachment suffer from harsh conditions, low efficiency, and limited control over ligand orientation. These drawbacks compromise the targeting performance and are believed to result in the current absence of a targeted drug delivery system on the market. In this project, we propose a simple, efficient, and mild attachment method to spontaneously activate on demand nanocarriers. This innovative approach has the potential to have a multi- level effect, first to revolutionize various fields, including drug delivery, diagnostics, and nanotechnology, by providing advanced tools for targeted therapies and diagnostics. Secondly, by developing novel methodologies that can be applied to existing technologies to enhance uptake, localization, and efficacy while minimizing systemic toxicity thus potentially shifting the health- economic balance for some treatments which were previously inaccessible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SecUre iNFormation SHaring in federated heterogeneous private clouds'.

assistant: **Concept**

Today the European Public Sector Players lack the necessary infrastructure and technology to allow them to integrate their computing clouds. Furthermore, legislative barriers often make it difficult to use available commercial technological solutions. The SUNFISH project aims to provide a specific and new solution to face these issues. SUNFISH will enable the secure federation of private clouds based on the Public Sector needs: federated private clouds belonging to different Public Sector Entities will be able to share data and services transparently, while maintaining required security levels.The SUNFISH project will develop and integrate software enabling secure cloud federation as required by European Public Sector bodies. The project will achieve this by meeting firstly the specific challenges faced by the Maltese and Italian Ministries of Finance, as well as by the UK Regional Cyber Crime Units, the three SUNFISH selected use cases. Solutions will be developed to be usable by other European Public Organisations, and potentially also by private sector players.SUNFISH will improve security in federated “cross-border” clouds, boosting the development of a cloud computing market in sectors where privacy and control of information propagation are essential (e.g., e-government, e-health etc.) while encouraging a better resource utilisation of Public Administration cloud infrastructure.The secure system for federated private clouds developed through the project will guarantee a high level of safety, a continuous monitoring of inter-cloud communications, and the ability to roll out services cheaply, in a fast, flexible and secure way even between different private clouds. The SUNFISH project aims to reduce the management cost of private clouds owned by Public Administratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clean biomass staged gasifier based on a new tar cracking and ash slagging technics for efficient combine heat and power generation' to be submitted under Fourth Framework.

assistant: **Abstract**

OBJECTIVES OF THE PROJECT: Project industrial objective is to development of a new process characterised by the minimisation of the gas cleaning part. Details in the industrial objectives are: 1. a more higher tolerance towards quality of the feedstock (ash 15% and above, moisture up to 30% and above depending on gas cleaning), 2. a reduction of carbon content in the ash (98 to 99 % carbon recovery), 3. a reduction of the tar in the end gases to follow standards for engine uses, 4. a more robust and efficient gasification set up. TECHNICAL APPROACH: The approach will consist in: 1. Introducing a new device named Total Char Combustion and Tar Cracking Chamber (TCC)2 between the pyrolysis unit and the char reduction chamber in a stage divided gasified With this design, the char conversion takes place in 2 steps. The first step is the char reduction Chamber (CRC) whose main purpose is to convert as much as possible carbon of the char supplied directly from the pyrolysis unit into gas by means of reduction reactions. The second step takes place in the (TCC)2 whose purpose, with respect to the char is to perform a complete conversion of the remaining carbon from the CRC drain off and where pyrolysis gases are thermally cracked and residual ashes are vitrified and eliminated as slag. 2. Designing and implementing a new vibrated fluidization pyrolysis unit able to achieve an appropriate and constant quality of char with minimum preparation of biofuel with a good phase separation. 3. Offering the opportunity to orientate the process for gas and solid reactions by simple operating conditions as a function of the plant requirement and market condition EXPECTED ACHIEVEMENT: For all industrial partners, the achievements of the objectives should result in the following benefits: 1.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Physiological characterization of PK2 in the control of fertility, and its interaction with kisspeptins' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Reproduction is a complex process governed by the interplay of central and peripheral factors. The major signal controlling reproduction is the hypothalamic GnRH, responsible of the release of pituitary gonadotropins that drive gonadal function. Thus, diverse conditions disturbing reproductive function are related to defects in factors and/or routes involved in the control of GnRH release. As an example, kisspeptins (encoded by the Kiss1 gene) and their receptor GPR54 have emerged as essential gatekeepers of GnRH neurons, and disruption of kisspeptin/GPR54 signaling lead to hypogonadotropic hypogonadism (HH) in humans and mice (one of the most relevant breakthroughs in contemporary Neuroendocrinology). However, the mechanisms that regulate the hypothalamic Kiss1 system remain partially unknown. Recently, prokineticin-2 (PK2) and its receptor (PKR2) have been involved in the control of reproductive maturation and/or function, as loss-of-function mutations in either the receptor or the ligand lead to HH. Considering that PK2 was originally described as a circadian pacemaker from the suprachiasmatic nucleus (SCN; the central translator of the photoperiodic status to the organism) and that key aspects of reproductive function (such as the preovulatory LH surge; responsible for ovulation) are exquisitely timed, the AIM of this project is to explore the basis for the regulatory actions of the PK2/PK2R system on GnRH neurons, and to evaluate whether Kiss1 neurons operate as essential relay for such a transmission. To accomplish this goal, a combination of gene expression (RT-PCR, in situ hybridization), protein (ICC) assays and functional (hormonal) tests, will be implemented in wild-type and genetically-modified mice. Implementation of this project will broaden our basic know
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Biopigments to BIOelectronics: MOdelling Semiconducting EumelAnin-based InterfaCes' under Horizon 2020.

assistant: **Concept**

The overall aim of this proposal is to build a comprehensive model of ionic and electronic transport in organic bioelectronics considering a prototypical material, eumelanin, as a proof of concept. Bioelectronic devices are used in nanomedicine for implantable, wearable and sensing applications. Eumelanin is a natural biocompatible semiconductor with great potential in bioelectronics due to its joint electronic and ionic conductivity. However, a full picture of its interactions with water and electrolytes and how these influence its semiconducting properties is still missing, thus holding back a systematic improvement of eumelanin-based devices. This project will provide the first unified picture of eumelanin’s mixed conduction by simulating electronic and ionic charge transport at device-relevant scales and combining them in a numerical model. This will be achieved through four innovative steps towards eumelanin characterisation:  i) reactive molecular dynamics (MD) simulations will capture the details of water-eumelanin interactions;  ii) a classical MD approach will describe ionic conduction in hydrated eumelanin;  iii) electronic structure methods will relate eumelanin’s morphology to its electronic conductivity.  iv) The previous insight will be combined in a model describing mixed conduction in eumelanin-based devices, allowing the formulation of general design rules for the development of new bioelectronic materials. Planned collaborations with leading groups in eumelanin bioelectronics will provide experimental data to build and validate the model, resulting in high-impact publications and contributing to European competitiveness in bioelectronics. The complementary nature of the researcher and host’s research profiles is instrumental in fulfilling the complex,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated Quantum Information Technology' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

IQIT will develop and demonstrate novel routes towards scaling up physical devices for quantum in-formation science (QIS). Communication between different parts of a quantum processor by means of a quantum bus will receive particular attention. Developing a scalable technology will be pursued by first advancing two successful solid-state and atom-optical devices, namely A) arrays of superconducting qubits coupled to microwave resonators – here all-optical quantum computing will be explored for the first time in the microwave regime – and B) highly controlled ion trap systems. Then, decisive steps will be undertaken to combine these systems to form a scalable basis for processing of quantum information. This new, integrated scheme will be based on the simultaneous exploitation of superconducting qubits for fast and scalable computational tasks and of trapped ions for storage and processing of information with long coherence times. On the side of superconducting qubits, a highly innovative route towards all-optical" quantum computing will be explored. Here, the photons serving for transport of quantum information are in the microwave regime. On the ion trap side novel traps will be developed suitable for integration and new techniques will be derived to further increase the lifetime of trapped-ion qubits, thus making an essential contribution to the storage of quantum information. In addition, novel schemes for the creation of arbitrary entangled states within a trapped-ion register will be developed by taking advantage of long-range spin-spin coupling. This will enable fast and efficient information transfer between both types of quantum registers (solid state qubits and trapped ion qubits), which in turn, will be of central importance for the integration of the supercon