RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photonic Components for Ultra wideband Radio over optical Fiber' (UROOF).

assistant: **Concept**

The key goal for UROOF is to investigate building blocks for enabling the delivery of Ultra-wideband (UWB) radio signal over low-cost optical fiber. The aims are therefore to study, develop, test and implement very low cost conversion solutions for direct optical-to-UWB (O/UWB) and UWB-to-optical (UWB/O) based on innovative microwave photonic concepts.  Unlike state of the art radio-over-fiber (RoF) technologies that are used in the backbone of the wireless access systems, UROOF will address the challenges of the low-cost wireless personal area networks (WPAN). UROOF will study several approaches including: developing proof of concepts for O/UWB and UWB/O converters based on innovative optically controlled microwave converter (OCMC).  A further study will address enhanced electroabsorption transceiver (EAT) to UWB applications.  These converters will be integrated with the UWB radio frequency (RF) front-end and comprise the very low-cost access node for UROOF applications. Several UROOF applications will be investigated in the field trial:  (i) range extension of WPAN over 1000m carrying real-world UWB signal with 480 Mb/s data rates and, (ii) very low-cost antenna distribution system (VL-DAS) for multicell WPAN applications. We will provide detailed theoretical and practical analysis related to the design, performance, manufacturing and implementation of UROOF novel modules including: performance analysis of the different modulation schemes in UWB to determine the optimum RoF distribution configuration, evaluation of the impact of electro-optical device non-linearities (pulse chirp / chromatic dispersion) on the UROOF distribution network, device suitability studies for multiple-access architecture VL-DAS, uncooled VCSEL-based design and optical-UWB link analysis.  The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nuclear science for sustainable environment and security. inrne - jrc conference - informational days' (NUSES), addressing dissemination and exploitation.

assistant: **Impact**

The proposed measure has three milestones : preparatory work, public relation & media support and conference - informational days themselves. The most important expected results are :increased networking between INRNE, JRC Institutes and other EU Centres of excellence;increased scope of INRNE;contribution to capacity building;increased linkage with and support for economic and social needs of the Bulgaria (South-East European countries);diversified participation of INRNE in EC programs .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Organisation of the EU international Bioeconomy Stakeholders Conference - Utrecht 2016' (BEU2016).

assistant: **Innovation**

In order to cope with an increasing global population, rapid depletion of many resources, increasing environmental pressures and climate change, Europe needs to radically change its approach to production, consumption, processing, storage, recycling and disposal of biological resources. The Europe 2020 strategy calls for a Bioeconomy as a key element for smart and green growth in Europe. However, the complex inter-dependencies that exist between challenges can lead to trade-offs, such as the controversy about competing uses of biomass. The latter arose from concerns about the potential impact of the growing demand for renewable biological resources by other sectors on food security, the use of scare natural resources and the environment in Europe and third countries. On 13th of February 2012 the EU launched the Bioeconomy strategy and action plan on ""Innovating for Sustainable Growth: a Bioeconomy for Europe"", which aims to pave the way to a more innovative, resource efficient and competitive society that reconciles food security with the sustainable use of renewable resources for industrial purposes, while ensuring environmental protection.In this respect the Strategy stresses that participatory models are needed that engage citizens and end-users in order to reinforce the relationship between science, society and policy making. More informed dialogues will in fact allow science and innovation to provide a sound basis for policy making and informed societal choices by taking into account legitimate societal concerns and needs in the Bioeconomy.In this framework, and in support of the review and implementation of the strategy, this 4th Bioeconomy Stakeholders Conference on April 12-13 2016 will provided opportunity for public awareness raising and for an informed dial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel therapeutic approaches, based on drug repurposing, for high risk non muscle invasive bladder cancer driven by patients’ proteomic signatures'.

assistant: **Innovation**

Bladder Cancer (BC) is the costlier cancer type to manage, characterized by high recurrence and progression rates. Despite recent advancements, current BC therapeutic strategies remain suboptimal, mostly due to the disease molecular heterogeneity. Profiling at the transcriptomics and, very recently, proteomics levels, revealed the existence of a cross-omics conserved molecular signature marking progression from low to high risk non muscle invasive (NMIBC) and eventually muscle invasive disease. ReDrugBC targets to identify drugs, via drug repurposing, able to revert the aggressive molecular signature for NMIBC, hence tackling the disease at an earlier stage and on a more holistic manner. To address this state-of-the-art concept, ReDrugBC is divided into three highly interrelated strategic points: 1) drug identification (among existing compounds) for NMIBC based on the existent tissue molecular profiles analyzed in a multi-layer and multi-omics manner using specialized bioinformatics-drug prediction tools, 2) definition of impact of selected drugs on the functional properties of BC cell lines in vitro and 3) characterization and understanding of the drug impact on a molecular level, via the application of high-throughput proteomics analysis. This research program will be carried out in a research intensive SME-leader in clinical proteomics and multi-dimensional analysis, by a very active and promising young researcher originating from academia, in a multidisciplinary, implementation-oriented manner. Outreach activities include among others links to pharmaceutical companies and regulators to accelerate progress towards (pre-) clinical trials post-ReDrugBC. Collectively, the proposed approach in ReDrugBC paves the way for better treatment of NMIBC via drug selection based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'An integrated typology-based approach to guide the future development of European historic buildings towards a clean energy transition'.

assistant: **Objectives**

The process of future proofing the built heritage faces the paradox of needing standardised approaches but having a heterogeneous stock with very specific needs. FUTURHIST will rely on the identification and characterisation of local uniform building typologies, as a lowest common denominator, to develop tailored intervention approaches that can be standardised and replicated in all buildings of that category with minor modifications. The standardised approach will then serve as a basis for the adaptation to other typologies in the same context (climate, regulations, etc.) or even similar typologies (in terms of materials, configuration, etc.) in different contexts.Although considerable progress has been done in recent years in terms of development of materials and solutions compatible with conservation of historic buildings, several challenges remain still open. FUTURHIST will develop both passive and active solutions with a focus on an efficient use of energy and resources, improved wellbeing, enhanced durability, revalorization of existing materials and techniques, integration of renewable energy systems, and smart solutions for decarbonising heating, cooling, and ventilation. Mentioned here, just as examples, be a clay-biochar-insulation, self-healing lime plaster and hybrid original-vacuum glazing.Demonstration is at the core of the project. The solutions developed as well as the approach will be implemented and tested in four cases in Spain, Poland, Sweden, and the UK. The diversity and geographical distribution of the demo cases will ensure the validation under different climates, construction typologies and socio-economic environments. The demo case owners, as members of the consortium, will facilitate a rapid uptake of the results to be implemented in their lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Vesicular glutamate transporters as molecular regulators of neural communication'.

assistant: **Concept**

This proposal describes experiments aimed at defining the multiple roles of vesicular glutamate transporters (VGLUTs) in central synapses. Classically, VGLUTs transport glutamate from the cytoplasm into synaptic vesicles. Deletion of these genes disrupts synaptic glutamate release and their expression suffices to determine neurons as glutamatergic. We recently discovered that VGLUTs control additional key parameters such as quantal size and vesicular release probability, suggesting that they are fundamental regulators of synaptic strength and synaptic plasticity. To study these novel functions, we will first address whether the number of VGLUTs per vesicle (VGLUT content) can affect the amount of stored glutamate and in addition, the probability of vesicle release. We will subsequently explore the underlying mechanisms. Second, we will test the hypothesis that different VGLUT paralogs contribute to functional differences in discrete synapse populations, as implied by our preliminary data and the distribution pattern of the two main paralogs VGLUT1 and VGLUT2 in the brain. Subsequently, we will perform structure function studies on VGLUTs in native synapses to identify the underlying molecular interactions. Finally, the little understood VGLUT3 paralog is expressed mainly in subclasses of cholinergic, dopaminergic and GABAergic neurons, but no evidence exists that demonstrates VGLUT3 s role in glutamate release. We will address whether VGLUT3 is used to co-release glutamate with other neurotransmitters, and will test whether presence of glutamate in synaptic vesicles interferes with the storage or release of other neurotransmitters. Our studies will yield important insights into how these transporters operate, and how modulation of VGLUTs affects synaptic encoding and br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel approaches to identify brain responses specifically related to the perception of pain in humans' (2007-2013).

assistant: **Concept**

How does the brain process noxious stimuli, and how does this lead to the perception of pain? Human electrophysiological studies using electroencephalography (EEG) or magnetoencephalography (MEG), as well as studies using functional magnetic resonance imaging (fMRI) or positron emission tomography (PET), have all shown that noxious stimuli, or painful stimuli, elicit neural responses in a vast array of cortical structures. Although a large number of investigators have proposed that these brain responses form a cortical network specifically or preferentially involved in the perception of pain (i.e. the so-called “pain matrix”), the actual functional significance of these brain responses remains obscure. For example, recent studies have shown that these responses reflect brain processes that can also be triggered by non-noxious stimuli and that these may be largely related to non-specific mechanisms of arousal and/or attentional capture. Hence, to progress in our understanding of the cortical mechanisms underlying the perception of pain, novel approaches are needed to identify brain responses more specifically related to the processing of noxious input. This will constitute the main objective of the present research project, which will combine novel methods to analyse EEG, MEG and fMRI signals, with novel methods to activate the nociceptive system in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Late holocene shallow marine environments of europe (HOLSMEER)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Modelling predictions of the climate system's response to anthropogenic forcings are severely inhibited by inadequate understanding of natural climate variability. HOLSMEER proposes to improve our understanding of this natural variability through the search for, interpretation, and quantification of, climatic variability in high-resolution shallow marine records from Atlantic Europe covering the last 2000 years. Long-term instrumental time series of marine and atmospheric parameters will be used in a new way to calibrate the marine palaeoclimate observations, extending the marine record to the period before systematic recording of environmental parameters was undertaken, and therefore providing a basis for establishing the natural variability of the oceanic component of the climate system in the critical North Atlantic region prior to significant anthropogenic forcing of the environment. These data will validate numerical models of the climate system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'METRO High bandwidth, 5G Application-aware optical network, with edge storage, compUte and low Latency' (METRO-HAUL), addressing dissemination and exploitation.

assistant: **Impact**

METRO-HAUL is a project proposal addressing the Horizon 2020 ICT-07 5G PPP call; it is an RIA, focusing on strand 2 (high capacity elastic – optical networks) and strand 3 (software networks). The central topic is cost-efficient optical metro networks for 5G backhaul. The aim of this project is to design and build a smart, but cost-effective, optical metro infrastructure able to support traffic originating from heterogeneous 5G access networks, addressing the anticipated capacity increase and its specific characteristics such as mobility, low latency, and high bandwidth. This infrastructure will be able to also support a wide variety of 5G applications with special emphasis on services from various industries vertical to the ICT.This will be achieved by architecting new access-facing and core-facing nodes, complete with storage and compute facilities, interconnected by novel, spectrally efficient, and adaptive optical transmission networks. Advanced concepts, such as hardware disaggregation and virtualisation, will assist in hitting challenging cost targets whilst enabling automation and programmability – all supported by a purpose-designed SDN-based control plane which will interface with client applications, intelligently catering for the wide range of 5G KPIs. METRO-HAUL will coordinate the disparate elements of transmission, switching, networking, compute, and storage, orchestrating dynamic solutions for multiple 5G applications. METRO-HAUL will carry out Proof of Concept demonstrations of its networking solution involving the interconnection of metro node prototypes, the use of the project's transmission technologies, and the associated control plane and orchestration software. The final project demonstrations will also involve the demonstration of actual 5G and ve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modulation of RNA-based regulatory processes by viruses' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Small and large non-coding RNAs are essential components at the heart of gene expression regulation. The past fifteen years have witnessed the emergence of a new field of research impacting diverse domains of biology. Among these, virology is no exception and discoveries such as the antiviral role of RNA silencing, virus-encoded microRNAs (miRNAs), or miRNA-based regulation of viruses have notably shifted our views of host-virus interactions. Although we know a lot about the mechanisms of action of ncRNAs, and their role in the context of viral infections, we know much less regarding the control of the regulatory RNAs themselves. In other words, how are the regulators regulated? To provide answers to this burning question, we propose to use different viruses as models to investigate the various levels where modulation of regulatory RNA can occur. Thus, we will study the importance of RNA secondary and tertiary structure as well as accessory proteins in the regulation of miRNA primary transcript processing. In a second axis, we propose to investigate how the functional, mature miRNAs can be controlled. To this end, we will focus on the mechanisms of target-mediated miRNA decay and the role of competing endogenous RNAs. We will finally turn to the regulation of antiviral RNA silencing. Although it seems that this kind of defence mechanism exist in mammalian cells, it is not yet clear how physiologically relevant it is and how it interfaces with other innate immune mechanisms. In this multidisciplinary project, we will use a combination of techniques ranging from bioinformatics to cellular biology to achieve our goal to get a comprehensive view of how RNA silencing processes are regulated during virus infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Conductive suspension flows for soft electronics' (ELECTROFLUID), addressing dissemination and exploitation.

assistant: **Impact**

Today, most electronics and robots are based on solid metals and semiconductors. This project aims at “Electrofluids” that conduct electrons while flowing as liquids. Because liquids have virtually no yield strength, they are ideal materials to replace solid metal leads in truly soft devices. ELECTROFLUID uses highly concentrated suspensions that are liquid in a wide temperature range. Transient conductive networks in suspended particles of commonly used conductors provide high level of electronic conductivity at the viscosities required for soft electronics and robots. They contain common conductive materials such as carbon, silver, gold, and copper and do not require specialized low-melting alloys of gallium or other expensive elements.In order to create stable Electrofluids with large conductivity at low viscosity with tuneable rheology, I study the interplay between particle-particle friction, contact resistance, percolation, bulk resistance, and suspension viscosity. I use both custom-synthesized and commercial particles in a size range of tens of nanometres to few microns and with different shapes, modify their surfaces with conventional and pi-conjugated surfactants, and formulate concentrated suspensions that exhibit large conductivity at low viscosity. The combination of different particle sizes, shapes, and fluids enables tuning the properties of the fluid towards specific application cases, for example to create highly flexible leads for logic signals versus high-power connections for the connection of actuators. The fluids will be encapsulated in elastomer tubes or micropatterned surfaces as they are commonly used in stretchable electronics. The specific aims of the project are: (i) to design highly concentrated suspensions that form transient percolating ne