RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Second harmonic generation studies of fullerene dynamics on surfaces' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The project will enable the applicant to carry out experimental researc work in a well-equipped laboratory making use of state-of-the-art ultra-high vacuum technology, surface analytical techniques and ultrashort pulsed lasers. Training will be given in all the experimental aspects of the research project as well as in the theoretical interpretation of the experimental results.  By combining the available experimental techniques, the project aims to study dynamical processes involving clusters or large molecules on surfaces in real time. The main experimental technique to be employed will be second harmonic generation (SHG), combined with LEED; Auger and time-of-flight mass spectrometry. In the later stages, pump-probe techniques involving ultrashort pulsed lasers (ps-fs) will be used in order to obtain detailed dynamical information on the processes occuring on the surface. Processes which will be investigated include the photopolymerisation of fullerene surfaces and the production of diamond-like films from C60+ ion bombardment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Demonstration of NOPERSIST results leading to novel, validated diagnostic tests for active human and bovine tuberculosis' in the context of a Seventh Framework call.

assistant: **Objectives**

Tuberculosis (TB) in humans and  bovine TB  in farm animals are global health problems of immense social and economic importance.Human TB: Mycobacterium tuberculosis (M.tb) is a slowly replicating bacillus that resides intracellularly within phagosomes of macrophages and commonly causes latent infections of the lung and in about 5% of the infected individuals it leads to active disease. Co-infection with M. tuberculosis is estimated in about one-third of HIV-1 infected subjects. Indeed, the risk of developing M. tuberculosis as an opportunistic infection is increased up to 200-fold in HIV-1+ subjects. Drug resistance to HIV-treatment and appearance of multiple-drug resistance (MDR) and off late of Extra-Drug Resistance (XDR) strains of M. tuberculosis, the causative agent of human TB is steadily leading to a hopeless situation as far as the therapy is concerned.Bovine TB: Bovine tuberculosis is caused by the bacterium Mycobacterium bovis, which is closely related to Mycobacterium tuberculosis, the cause of human tuberculosis. M. bovis can be transmitted to humans through the ingestion of unpasteurised milk and milk products as well as aerosols, from infected cows. The introduction of pasteurisation eliminated transmission through contaminated milk and greatly reduced the human health problem1. The principal hosts for bovine tuberculosis are cattle and buffalo, however many other domestic and wild animals can become infected e.g. goats, cervids, pigs, wild boars, dogs, cats, camels, badgers, primates, hares, amongst others. Bovine tuberculosis is found worldwide. All developed countries currently have a TB eradication program in place for many years. These programs have been largely successful; however, incidences are increasing in many countries (e.g. UK, Ireland, Franc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Functional and structural changes of brain circuitry in altered oxygen conditions'.

assistant: **Concept**

Maintaining the oxygen (O2) concentration at an appropriate level is the most important task for the survival of a living organism. Both low level (hypoxia) and high level (hyperoxia) of O2 have deleterious effect on cells. Brain is especially sensitive to O2 change. These induces a variety of alterations in neuronal function, ionic homeostasis and cell morphology. Recording the network and single cell activity at various O2 concentrations in vivo in anesthetized and freely moving rats. The concentration of the inhaled O2 will be continuously monitored during the experiment. Cortical EEG activity will be recorded with animals in normoxic (21% O2), hyperoxic (30%, 50%, 70% and 100% O2) and hypoxic (16% and 10% O2) environment. A 16-64 channel multielectrode array will be inserted into the somatosensory cortex to record spontaneous electrical network activity. This technique enables us to record the electrical activity of a single cell, and determine the neuroanatomical (axon and dendrite arborization) and neurochemical characteristic of the cell. Based on these observations, our specific aims are to determine: Identify the distinct cell population(s) that are most vulnerable to the altered O2 concentrations. What are the potential long-term neurophysiological and behavioural outcomes of hyperoxic and hypoxic conditions. What is the relationship between these general outcomes and the activities of cortical inhibitory interneurons will also be addressed in the future. This project will combine various electrophysiology, neuroanatomy and behavioural approaches. The proposal has strong multi-disciplinary aspects as well since it involves the combined efforts of expertise from medical sciences, cell biology and computational science. It also has the potential prospect for pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Thresholds in human exploitation of marine vertebrates' to be submitted under Horizon 2020.

assistant: **Abstract**

SeaChanges provides state-of-the-art training to forge a new generation of interdisciplinary researchers able to operate at the interface of archaeology and marine biology. The seas are crucial to European economy, identity, and food security, as recognised by H2020 Blue Growth. Marine resource use has influenced European societies for millennia, and we in turn have impacted the seas. The need for long-term perspectives to inform marine management is becoming clear, but disciplinary silos hold back integration of archaeological data/approaches to this end. SeaChanges brings together experts from 7 leading institutions in archaeology, zoology, marine ecology & conservation biology, united by our recognition of this gap. We will pool our disparate skills and experience in an integrated training programme, creating a new generation of researchers who from the outset of their careers have the interdisciplinary understanding & skills required fully to realise the potential of archaeological remains to a) understand past marine resource use, b) assess past impacts, and c) use these to inform the present. SeaChanges will:1) develop a truly interdisciplinary training platform, breaking down boundaries between archaeological & biological sciences.2) improve understanding of the time depth of human use of and impact on key European marine species.3) train a cohort of researchers who can communicate across disciplinary and sectoral boundaries, whose insights will drive the adoption of long-term perspectives into concepts of sustainable fishing.4) increase cross-disciplinary and cross-sectoral awareness of the potential of long-term perspectives in marine ecology.This is achieved via dedicated training in bioarchaeology, ecology, and communication, supporting a network of 15 comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trustworthy Artificial Intelligence for Personalised Risk Assessment in Chronic Heart Failure' to be submitted under Horizon Europe.

assistant: **Abstract**

Cardiovascular diseases remain the main cause of mortality worldwide; in particular, heart failure (HF) poses complex challenges in clinical practice, as it is associated with a significant variability in aetiologies, manifestations and risks, as well as in its progression and trajectories over time. Clinical risks of HF can vary from reduced cardiac function and regular hospitalisations, all the way to cardiac events and mortality. There is a need for a personalised medicine approach to tailor the care models (i.e. lifestyle changes, medications, interventions) to each HF patient’s risk profile and hence optimise the clinical outcomes. Artificial intelligence (AI) solutions trained from multi-source cardiovascular data have the potential to dissect the precise characteristics of each patient and predict their likely trajectories at an early stage. However, existing AI methods remain a far distance from clinical transfer and adoption due to a common and key limitation: their trustworthiness and acceptance by cardiologists and patients alike have not been achieved.AI4HF will develop the first trustworthy AI solutions for personalised risk assessment and management of HF patients. The project will build on a unique set of big data repositories, trustworthy AI methods, computational tools and clinical results from major EU-funded projects in cardiology. To test robustness, fairness, transparency, usability and transferability, the validation with take place in eight clinical centres in both high- and low-to-middle-income countries in the EU and internationally. AI4HF will develop a comprehensive and standardised methodological framework for trustworthy and ethical AI development and evaluation based on the FUTURE-AI guidelines developed by the consortium members. AI4HF wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecularly guided trials with specific treatment strategies in patients with advanced newly molecular defined subtypes of colorectal cancer (MoTriColor)' (MoTriColor), addressing dissemination and exploitation.

assistant: **Impact**

Colorectal cancer (CRC) is increasingly being recognized as a heterogeneous disease with distinct molecular subtypes. These subtypes have different biological processes at the basis of their disease and consequently their prognosis and responses to therapy are also different.We have previously developed molecular diagnostic assays using a single platform on routine FFPE tumour biopsies. These assays identify gene expression profiles with distinct prognosis and drug response phenotypes (CMS4/c-type, BRAF mutant-like, and MSI-like). Our overall objective is to develop targeted therapies more effective than the current therapies that do not take advantage of molecular classification of the disease to select patients for therapy. We therefore propose to perform 3 two-stage single arm multi-centre open-label phase II studies based on solid preclinical evidence and a sound scientific rationale for these subgroups of CRC patients: 1) combination of chemotherapy and a TGF-βR inhibitor (LY2157299) in patients presenting a C-type signature; 2) vinorelbine in patients with a BRAFm-like signature; and 3) an immunotherapeutic anti-PD-L1 drug (MPDL3280A) in combination with bevacizumab  in patients with a MSI-like signature. The primary objectives of these studies are to determine the clinical efficacy (progression-free survival as primary endpoint), safety and tolerability of the experimental treatments in these molecularly selected populations. Mutation analysis at the beginning of treatment and monitoring by liquid biopsies might reveal further biomarkers that predict response in retrospective analysis.The project outcomes may have a significant impact in CRC patients with poor-risk prognosis worldwide as 40-50% of them present gene expression profiles matching one of the 3 approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intelligent Innovative Smart Maintenance of Assets by integRated Technologies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

IN2SMART represents the 1st proposal of the Shift2Rail members referred, according to MAAP, to the following Technology Demonstrators (TDs): TD3.7 Railway Information Measuring and Monitoring System (RIMMS), TD3.6 Dynamic Railway Information Management System (DRIMS) and TD3.8 Intelligent Asset Management Strategies (IAMS). These TDs will deploy an overall concept for Intelligent Asset Management based on the following three main interlinked layers:•Measuring and Monitoring systems to collect data from the field related to the railway assets status: IN2SMART will develop unmanned systems for “remote” monitoring; track geometry, switches & crossings and signalling monitoring systems; innovative measurement of train parameters and wheel defects combined with rolling stock identifications systems.•Data management, data mining and data analytics procedures to process data from the field and from other sources: IN2SMART will develop standard open interfaces to access heterogeneous maintenance-related data; analytic tools to automatic detect anomalies, discover and describe maintenance workflow processes and predict railway assets decay towards prescriptive maintenance.•Degradation models and decision making tools to support maintenance strategies and execution: IN2SMART will lay the foundation of a generic framework for asset management and decision support process. This framework will specify the scope, objectives, workflow and outcomes of the decision-making process for maintenance interventions planning, and will be the enabler for the development of future decision support tools and systems. IN2SMART will also develop an optimised tamping tool and a robot platform for maintenance works.IN2SMART will complement the work of the IN2RAIL lighthouse project to reach a homogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Identification and functional characterization of genetic cancer risk variants'.

assistant: **Concept**

This Industry-Academia Partnership and Pathways (IAPP) joins three groups which have hitherto focused on different aspects of cancer genetics. deCODE genetics (deCODE) has recently identified several genetic risk variants that are associated with increased risk of cancer, including two distinct genetic prostate cancer risk variants on chromosome 8q24.  The University of Torino (UNITO) group has identified a number of germline SNPs in signal transduction genes that are frequently mutated in tumors and the group has developed an innovative technology for knock-in of genetic variants in order to reconstruct genetic events in tumor progression.  The Karolinska Institute (OP-KI) group has developed sophisticated tools for cytogenetic studies on tumors.  The major objective of this proposal is to perform functional and cytogenetic analysis on several of the cancer risk variants identified by deCODE and UNITO.  The major objectives of this proposal are 1) to discover and validate low-medium frequency polymorphisms that predispose to cancer, 2) to functionally validate the newly identified variants in human cells, 3) to identify biological properties associated with the prostate cancer risk alleles located at 8q24.  Collaboration between deCODE, UNITO and OP-KI benefits all three partners since the capacities and technical skills are largely complementary. The collaboration is foreseen as an ongoing partnership aimed at elucidating the biological properties of genetic variants conferring risk of cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New epigenetic therapy for high-risk neuroblastoma' (MIRNATHERAPYNBL), addressing dissemination and exploitation.

assistant: **Impact**

Neuroblastoma (NBL) is the most common solid tumor of infancy. Nearly 45% of all children with NBL are designated as high-risk patients and 60% of them die. Therefore, there is an urgent need to identify and target the molecular programs that are responsible for NBL aggressiveness, especially those that contribute to metastasis and resistance to chemotherapy.Recently, it has become evident that microRNAs (miRNAs) are deregulated in numerous diseases including cancer. Particularly in NBL, there is a global reduction of miRNA levels, especially in high-risk patients, and the expression of miRNA processing machinery components (i.e. Drosha, Dicer) impact on patient outcome. MiRNA restoration can be the basis for novel forms of therapy, by limiting the metastatic potential of NBL tumor cells and/or enhancing their sensitivity to current forms of treatment.The overall goal of my research will be to restore the levels of miRNA using a full miRNA library (1200 miRNAs) in highly chemoresistant NBL cells, and monitor the response with the miRNA alone or in combination with currently used chemotherapy drugs. The effect of the miRNA(s) will be validated in a expanded panel of NBL cell lines. Furthermore, we plan to develop a therapeutic tool based on nanoparticles, to target NBL cells in vivo and overexpress the target miRNA.Finally, the levels of those miRNA are going to be evaluated retrospectively in FFPE archived samples, in order to determine if the expression of a particular miRNA (or a signature) can be a biomarker of disease, indicator of minimal-residual disease or response to therapy and, correlation with overall or post-recurrence survival.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Complete ambient assisting living experiment'.

assistant: **Concept**

Europe faces a social change, which is brought about by the unprecedented demographic change: the share of elderly people to the entire population is steadily growing, while the share of the youngest, especially the working population is shrinking. Ambient Assisted Living (AAL), as a specific user-oriented type of Ambient Intelligence", may greatly help in this situation.AAL aims to prolong the time people can live in a decent more independent way by increasing their autonomy and self-confidence, by allowing them to discharge normal everyday activities, by improved monitoring and care of the elderly or ill person, by enhancing their security while ultimately saving resources. The main objective is to develop a wearable light device able to measure specific vital signs of the elder or ill person, to detect falls and to communicate autonomously in real time with his/her caregiver in case of an emergency, wherever they are. The emergency information can be directed to the personal caretaker and/or the 112 Emergency Service.The emergency information will provide the geographic position and health information of the elder in a sensible way for the caretaker or emergency service. The incorporation of largely non-intrusive new sensors for fall detection and highly sensitive positioning is expected to address many of the elderly concerns about adopting technology. The monitoring device for the caretaker can range from a mobile phone and/or a more complex system so that an integrated caretaking service can be created to look after groups of elders.In this case, when monitoring the elder at home, the system will be complemented with other devices such as cameras in a way that personal services can be established for the elder. The system will be tested in a real usability site ar