RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A nanotechnology roadmap for the forest products industry' (NANOFOREST) targeting Sixth Framework.

assistant: **Abstract**

The overall objective of NANOFOREST is to recognize new and emerging developments in Nan technology and related areas suitable for practical application in the forest products sector. As an important task NANOFORESTwill search for relevant European inter-disciplinary research, networking and international cooperation to promote the collaboration between the forest products industry cluster and relevant fields of Nan technologies andnanosciences. The forest products cluster is strong in the Nordic countries due to their large forest resources. The European chemical industry cluster is the strongest in the world. A close and symbiotic relation between the European forest industry and chemical industry clusters in the development of Nan technology for refinement of renewable forest raw materials would provide a substantial step towards global competitiveness and a sustainabledevelopment. The question NANOFOREST aims to answer is if Nan technology can provide the forest products industry with radical innovative changes in its production processes in order to enhance competitiveness of the products or find new 'smart' product areas, along with an improved sustainability. The partnership involves researchers from two research institutes, STFI (contractor) and TRAETEK (subcontractor), and two universities, KTH (subcontractor) and HUT (subcontractor), active in central fields of forest products oriented research. The senior researchers have scientific excellence and are heading research areas suitable for fast introduction of Nan technology approaches. The partnership covers the forest products industry from fundamental scientific levels to industrial implementations.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Predicting changes in species interactions following species loss in hydroelectric reservoir islands' under Horizon 2020.

assistant: **Concept**

The burgeoning energy demand worldwide has led to a proliferation of hydroelectric dams, firstly in the northern hemisphere and subsequently across tropical developing countries, which have become the new hydropower frontiers. Currently, hydropower development is already one of the primary means of habitat loss and fragmentation in tropical forests, hence a key threat to biodiversity and the ecosystem services provided to the entire humanity. After damming, all low elevation areas are inundated, while previous ridgetops in undulating terrain often become islands. The objective of this Marie-Skłodowska-Curie Action is to dissect the ecological impacts of habitat insularization induced by hydroelectric dams on ecosystem functioning, by comprehensively assessing species interactions across 35 forest islands and three mainland continuous forest sites across one of the largest hydroelectric reservoirs in South America. Firstly, specific prey-predator interactions – herbivory, insectivory and seed predation – will be quantified in situ and related to patch, landscape and habitat-quality metrics. Then, species interactions across terrestrial food webs will be evaluated using theoretical approaches based on species co-occurrence and codispersion analysis. To do so, the Experienced Researcher will use data previously collected by the host research group on vertebrate, invertebrate and plant species, and apply novel framework approaches based on mutualistic and antagonistic networks, some of them developed by the collaborator group. The innovative knowledge to be produced is expected to considerably improve strategic environmental impact assessments of planned hydroelectric dams and manage existing and future hydropower development. Moreover, while collaborating with very-high pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'International Randomized Study Comparing personalized, Risk-Stratified to Standard Breast Cancer Screening In Women Aged 40-70' (MyPeBS), addressing dissemination and exploitation.

assistant: **Impact**

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis. Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances. MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy,  UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of isomerisation of green leaf volatiles in fine-tuning tritrophic interactions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Plants continuously emit organic volatiles into the air, but upon herbivory the amounts increase dramatically. Emission of herbivore-induced plant volatiles, i.e. especially of terpenoids, aromatic compounds and C-6 based ‘green leaf volatiles’ (GLVs), leads to the attraction of foraging natural enemies of herbivores and therefore is referred to as indirect plant defence. We recently found that the increased emission of (E)-isomers of GLVs, induced in wild tobacco (Nicotiana attenuata) by tobacco hornworm (Manduca sexta) feeding, tripled the foraging efficiency of its natural predators in nature. Surprisingly, we discovered that the conversion of the plant’s (Z)-aldehydes to (E)-aldehydes was solely and directly due to isomerase activity in the herbivore’s oral secretions (Allmann and Baldwin (2010) Science 329). The fact that the insect thus betrays its whereabouts to its enemies raises an intriguing question: why did evolution not select against the presence of this enzyme? Here I propose to characterize the enzyme responsible for GLV isomerisation and to elucidate its function in the caterpillar’s physiology, life history and ecology. First I will purify the enzyme, clone the corresponding gene and cDNA, and characterize the enzymatic properties; second I will describe the expression and activity throughout the hornworm’s life cycle; thirdly I will manipulate its expression to investigate the consequences of increased or decreased emission of GLV (E)-isomers for the caterpillar’s growth, development and immune response. Finally, I will investigate the costs and benefits of GLV-isomerisation by tobacco hornworms under natural conditions in the field. Doing so I expect to learn which physiological or ecological benefits have allowed the insect to maintain this treacher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Molecular and clinical markers for diagnosis and management of type 1 von willebrands disease'.

assistant: **Objectives**

Type 1 von Willebrands disease (VWD) is the most common inherited bleeding disorder and results from deficiency of von Willebrand factor (VWF), a plasma protein required for normal haemostasis. Diagnosis is based on laboratory tests and a bleeding history, but can be equivocal. Precise diagnosis is important for the patient and family; misdiagnosis leads to unnecessary medical and social burdens. This project will determine molecular and clinical markers for the diagnosis and management of type 1 VWD by assessing 200 families with type 1 VWD, recruited by 12 Partners. The phenotypic basis of the diagnosis will be re-examined utilising International standards and result confirmation, new tests will be assessed and the genetic basis determined by VWF gene analysis and expression. Data on precise molecular, clinical and laboratory markers for type 1VWD will be produced.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neurodegenerative disorders: from biology towards clinical applications', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Neurodegenerative disorders of the central nervous system (CNS) such as Alzheimer's (AD) and Parkinson's diseases are devastating and ever increasing health problems for which there is no effective treatment. Neurotrophins prevent neuronal degeneration produced by injury or normal aging and these factors are currently being tested in clinical trials for treatment of neurodegenerative disorders. Because neurotrophins do not penetrate the blood-brain barrier, they would have to be administered into the brain ventricles for the treatment of AD. However, neurotrophins, in particular brain-derived neurotrophic factor (BDNF) are relatively abundantly expressed in normal brain and only slightly reduced in AD brain 1 (for references see p.7) suggesting that the problem in degenerative disorders is not the lack of neurotrophins but their compromised signaling capacity. Treatments that enhance the ability of endogenous neurotrophins to activate their receptors would therefore represent a new therapeutic approach in the treatment of these devastating disorders. TrkB, the receptor for BDNF and neurotrophin-4, is alternatively spliced into several different types of receptor isoforms. Extracellularly we have recently found two variants, L1 and L0, which lack two or all three of the leucine-rich domains and do not bind any neurotrophins2. Intracellularly there are the full-length, tyrosine kinase (TK) domain-containing form TK(+) and the truncated form TK(-)3. These isoforms are identical in their extracellular and transmembrane domains, but in place of the intracellular TK domain, TK(-) forms only contain short unique intracellular tail regions. Both receptor variants bind neurotrophins, but only TK(+) can activate intracellular signal transduction. TK(-) forms may influence the fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automated financial modelling' (AUTOFIM) targeting Sixth Framework.

assistant: **Abstract**

Traditionally automated quantitative financial modelling faced great challenges with respect to computation, implementation and maintenance, since most financial models are highly non-linear and thus require rocket science skills, substantial effort and advanced technology. Recently, however, a methodology was proposed and developed in a series of papers which overcomes many of the computational challenges earlier associated with automated financial volatility modelling. Moreover, softwares (for example PcG ets) in which the methodology can be implemented in an automated manner is already available, so that only minor modifications and additions to the methodology are necessary before it can be used in automated financial modelling.The software PcGets implements an econometric methodology called general-to-specific (GETS) modelling, thus the name PcGets, and the modelling framework is sometimes referred to as LSE econometrics after the academic institution (London School of Economics and Political Science) in which it originated. More recently though the approach has become widely associated with David F. Hendry at the University of Oxford. In brief, the methodology consists of starting with a general model that adequately characterises the data, and then simplifying it while paying careful attention to the model properties.The methodology provides a systematic framework for statistical economic hypothesis testing, model development and model evaluation, and the methodology is popular among large- scale econometric model developers. However, it is unused for the purpose of financial econometric modelling. The aim of the project Automated Financial Modelling is to implement and evaluate the usefulness of automated valute-at-risk modelling and automated derivative price m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Supporting and standardizing climate services in Europe and beyond'.

assistant: **Objectives**

Timely delivery and effective use of climate information is fundamental for a green recovery and a resilient, climate neutral Europe, in response to climate change and variability. Climate services address this through the provision of climate information for use in decision-making to manage risks and realise opportunities.The market and needs for climate information has seen impressive progress in recent years and is expected to grow in the foreseeable future. However, the communities involved in the development and provision of climate services are often unaware of each other, and lack interdisciplinary and transdisciplinary knowledge. In addition, quality assurance, relevant standards, and other forms of assurance (such as guidelines, and good practices) for climate services are lagging behind. These are needed to ensure the saliency, credibility, legitimacy and authoritativeness of climate services, and build two-way trust between supply and demand.Climateurope2 aims to develop future equitable and quality-assured climate services to all sectors of society by:●Developing standardisation procedures for climate services●Supporting an equitable European climate services community●Enhancing the uptake of quality-assured climate services to support adaptation and mitigation to climate change and variabilityThe project will identify the support and standardisation needs of climate services, including criteria for certification and labelling, as well as the user-driven criteria needed to support climate action. This information will be used to propose a taxonomy of climate services, suggest community-based good practices and guidelines, and propose standards where possible. A large variety of activities to support the communities involved in European climate services will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Reliability assured low cost offshore wind energy demo project'.

assistant: **Innovation**

The realisation of offshore wind energy projects has a high-risk profile because of:1) High investment cost,2) Restricted accessibility of the location,3) Technical risk.The objective of this project is to gain experience and to build up a track record with a small offshore wind farm, to demonstrate availability comparable with onshore installations and to verify the low cost tower design. The 10MW wind farm consists out of 5 turbines located 2km from the Dutch shore The electrical conversion system will be designed for a cluster of turbines in order to minimise number of components and to optimise cost thus contributing to the objectives mentioned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protein-ligand data generation at scale to support computational hit finding and optimization' in the context of a Horizon Europe call.

assistant: **Objectives**

The ability to discover and optimize small-molecule ligands by using innovative physics-based, machine learning (ML) and artificial intelligence (AI) approaches would transform and democratize the discovery of new small molecule drugs and related research tools (chemical probes), with important implications for the development of new medicines for rare and pediatric diseases, cancer, and women’s health. The development of these methods is being held back by the lack of high-quality protein-ligand data in the public domain. To fill this gap, we have assembled a multi-sector public-private partnership that will generate high-quality, ML-ready, open protein-ligand data at scale and as a public good, and will engage with the research community to build, benchmark and test new machine learning models for small molecule discovery and optimization. Our ambition is to identify drug starting points for >500 human proteins and transform and democratize small molecule drug discovery.


**Keywords:** Chemical probes, drug discovery, AI/ML, community engagement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Technological Capabilities Building in the Software Industry in Bulgaria'.

assistant: **Innovation**

The proposed project explores the technological capabilities building in the software industry in Bulgaria. The project makes two major contributions to the existing body of literature. First, it develops an approach for analysing technological capabilities in a latecomer software industry, which has not been done so far. Second, undertaking the analysis in a transition country context allows to explore the impact of institutions in the process of technological capabilities building, an issue, which has been overlooked in the literature about technological capabilities building.   The research adopts an interdisciplinary perspective in order to enrich our understanding about the process of technological capabilities building and to make the concept of technological capabilities building more cohesive. The research explores the process of technological capabilities building in the two major groups of companies to be found in the Bulgarian software industry domestic-oriented and export-driven companies. The study is based on qualitative and quantitative research, drawing upon the results from two surveys and case study research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fuel-cell - flywheel hybrid vehicle' to be submitted under Fifth Framework.

assistant: **Abstract**

There is an urgent need to address the problem of deteriorating air quality and physical environment in urban centres, due to the increasing levels of traffic congestion. The aim of this project is to develop a zero emission hybrid propulsion system for a light rail vehicle comprising a fuel cell and flywheel energy store. The flywheel provides the traction power and recovers the brake energy while the fuel-cell provides the constant low level of primary power needed to maintain the stored energy. It is proposed to develop, prove and exploit the system initially for use in zero emission ultra light rail vehicles and eventually as a zero emission alternative to the internal combustion engine in a whole range of conventional road vehicles and provides a low cost alternative to the electrification of light rail schemes.