RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Middlebrow Enlightenment: Disseminating Ideas, Authors, and Texts in 18th-century Europe' (MEDIATE).

assistant: **Innovation**

Intellectual history has long focused on a small number of authors and conceptual frameworks in studying societal change during the Enlightenment. Historians of the book have similarly restricted their vision, tending to privilege radical, subversive or forbidden texts. Yet ever since Daniel Mornet launched the history of the book approach a century ago, historians have recognized that it was authors who were not radical or subversive who produced the best-selling texts of the 18th century. This project will push Enlightenment studies in a new direction by moving beyond the present, narrow corpus of texts and models that dominate the field, and propose a new conceptual framework that takes as its starting-point the heuristic concept of middlebrow culture. Developing a state-of-the-art database, it will, firstly, identify not the ‘high’ Enlightenment texts studied by the history of ideas, and not the ‘low’, forbidden texts of book history, but the real best-sellers of the 18th century. These were the texts that, to readers on the ground, represented the most visible face of the Enlightenment, but have hitherto never really been studied. Secondly, it will elaborate a typology of this corpus describing its generic traits, intended readers, relation to major political-religious debates, and how readers in different parts of Europe appropriated these texts through translations, reworkings and other uses. Finally, it examines how historiography came to define the Enlightenment as the work of an intellectual elite, downplaying the impact of middlebrow texts and readers. The project thus brings an ambitious, bottom-up approach to intellectual history, using book history data and innovative digital tools to argue that the Enlightenment was fashioned not only by the progressive i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enabling Noble Metal Reactivity with Earth-Abundant Metals for Selective Bond Functionalization Strategies' under Horizon Europe.

assistant: **Concept**

The functionalization of C=C and C–X bonds (X = I, Cl, Br, and H) is fundamental in organic chemistry for making carbon-carbon bonds or for introducing molecular complexity. Chemists have traditionally relied on precious metals catalyst such as palladium, platinum, and iridium to facilitate these transformations. Some of these metals, if not all of them, are one of the rarest on earth, leading to increasingly high prices and uncertainty in future supply chains. As their availability continues to decline it is important to address the scarcity of these metals to secure a sustainable future. One solution is to develop new technologies that allow one to substitute the precious metal catalysts for those that are abundantly available (e.g., iron), without sacrificing on performance and selectivity. Because of the fundamental differences between the properties of iron (one-electron chemistry) and the second/third-row transition metals (two-electron chemistry), this approach has shown to be a daunting task. If, however, it could be shown that iron could reliably engage in two-electron chemistry, then the reactivity of precious metals could be unlocked for iron. Through bespoke ligand design we will attempt to unlock this two-electron chemistry and apply it to three of the most common reactions in organic synthesis; (i) cross-coupling, (ii) alkene metathesis, and (iii) C–H bond functionalization. By relying on a distinct two-electron mechanism, a treasure trove of possibilities for selective bond forming reactions is generated. Overall, this work is expected to result in new avenues in earth-abundant metal catalysis and provide new methodologies to construct ever important C-C and C-N that can be used to induce molecular complexity.


**Keywords:** Earth Abundant Metals,  Iron,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultrafast Dynamic Imaging of Complex Molecules' under Seventh Framework.

assistant: **Concept**

High order harmonics are generated when molecules are ionized by an intense femtosecond laser pulse. The freed electron is accelerated in the external driving electric field and, because of the periodic oscillation of this field, is brought back to the parent ion, where it can recombine and give rise to the emission of an XUV photon. This XUV harmonic radiation has been shown to contain information on the electronic structure of the molecule, which can be interpreted as a picture of the molecular orbital. The idea of exploiting high order harmonic generation (HHG) for the tomographic reconstruction of the electronic structure in molecules was first introduced in 2004 for nitrogen molecules. Up to now, despite several attempts, a successful investigation of the molecular structure by HHG was still lacking for molecules more complex than N2. Recently I demonstrated a new experimental and theoretical approach for extending the imaging of molecular orbitals to a triatomic molecule. However, the real breakthrough in molecular imaging, namely the achievement of a time-resolved tomography providing a movie of the wavefunction of molecules while undergoing structural changes, has not yet been attempted.The goal of this project is to develop time-resolved HHG tomography for real-time imaging of evolving electronic structure in complex molecules undergoing electronic or vibrational excitation.The key idea of UDynI is to use a mid-IR (1.3-1.8 µm) few-cycle laser source to drive the harmonic generation process. This will allow tackling the limitations that prevented up to now the realization of time-resolved tomography of complex molecules during molecular rearrangement.I will mainly consider organic molecules, such as hydrocarbons, hydrocarbons with functional groups and aromatic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MANUFACTURING AND ASSEMBLY OF MODULAR AND REUSABLE EV BATTERY FOR ENVIRONMENT-FRIENDLY AND LIGHTWEIGHT MOBILITY' (MARBEL) targeting Horizon 2020.

assistant: **Abstract**

With the goal of accelerating the mass market take-up of ultra-high-performance batteries for battery electric vehicles (BEV) and plug-in hybrids (PHEV), MARBEL will base its approaches, solutions and innovations around the versatility concept as an axis within the entire project. It will focus on the need for fast charging and long-lasting batteries to boost end user demands, while applying high modularity and easy assembly and developing novel testing methodologies for safety, profitability and circularity. MARBEL will design, develop and demonstrate new modular, compact, lightweight and high-performance battery packs together with flexible and robust battery management systems for these BEV and PHEV, while maintaining safety levels, allowing fast, high quality and cost-effective large-scale production and following the “made by Ecodesign” principles. A set of modules easy to pack together and to disassemble would ease the manufacture and dismantling of different battery configurations sharing the same production process and common elements. MARBEL will develop and qualify future and innovative performance- and safety- related test procedures of developed functionalities such as the use of miniaturized housings, a flexible test-bench simulating integration-in-EV conditions (electric Vehicle In-the-Loop, eVIL) and artificial intelligence as a tool to reduce the time of laboratory experiments. MARBEL aims at a triple win, for people, business and planet. MARBEL is expected to generate scientific and technological impacts, boost the appearance and consolidation of new players (especially SMEs) and business models, reinforce the European position in the global battery market, and contribute to environmental and societal targets.MARBEL consortium is made of 16 partners fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the role of NMDA receptors in K+ channel nanoscale organisation, surface dynamics and function' under Horizon Europe.

assistant: **Concept**

NMDA glutamate receptors (NMDAR) are undisputed key players in synaptic plasticity, a role that has been attributed to their calcium permeability. It emerged over the past decade that the membrane trafficking and nanoscale organization of NMDARs also plays a major role in synaptic adaptation. This was further substantiated by the discovery that patients autoantibodies targeting NMDARs (NMDAR-Abs) induce major psychiatric and neurological symptoms through compromised NMDAR surface trafficking but intact ionotropic function. NMDAR-Abs rapidly alter NMDAR membrane dynamics by disrupting their interaction with specific interactors whose membrane organization and function are also possibly corrupted.Herein, I hypothesize that the whole surface interactome of NMDARs, which is still poorly defined, is altered by NMDAR-Abs, explaining the complex neuropsychiatric presentation observed in NMDAR-Ab-positive patients. To tackle this, I will perform an unbiased proximity labelling approach coupled to quantitative proteomics to provide the first identification of the NMDAR surface interactome in hippocampal neurons, and determine how it is altered by patients NMDAR-Abs. Among the targets, the potassium K+ channels, which tightly control neuronal excitability, are of prime interest since they functionally interact with NMDARs, and preliminary evidence from the host laboratory show that NMDAR-Abs alter hippocampal neuron excitability. Using super-resolution microscopy and electrophysiology, I will test whether NMDAR-Abs modulate the membrane trafficking and nanoscale topography of K+ channels, impairing K+ channel currents. Genetic or pharmacological modulation will be used to question the membrane interplay between NMDARs and K+ channels in a pathological, as well as basal, context.T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '3D and 4D Bioprinting: Additive Manufacturing of Smart Biodegradable Hydrogels' (4D-Biogel) under Horizon 2020.

assistant: **Objectives**

The controlled behaviour of biological systems in response to external stimuli is ubiquitous in nature and perceived as a key requirement for the development of advanced functional materials. A good example found in nature is the so-called “sensitive plant” (Mimosa) that responds to touch by rapidly closing its leaves, as a defense mechanisms against herbivores. This quick response to touch is due to rapid water release from specialized cells located at the leaves. In attempt to mimic nature, 4D-BIOGEL project aims to combine new fully biodegradable water-filled hydrogels with additive manufacturing or 3D printing to design smart materials that can undergo a temporal change in their shape under the influence of an external stimulus, giving a 4th dimension to the previously designed 3D object. Light-sensitive structures activated by near-infrared (NIR) are especially appealing, since light can be conveniently pinpointed to the location of interest with the maximum depth of penetration and the minimum damage of tissues. To obtain NIR-sensitive hydrogels, nanoparticles capable of converting light into heat will be incorporated into the hydrogel matrix to afford small volume contraction-expansion changes on demand. This advanced technology offers great potential for the creation of sophisticated dynamic structures with high resolution that could find application not only in regenerative medicine or drug-delivery, but also in robotics or bioelectronics. The 24-month outgoing phase will take place at the University of Washington in Seattle, under the supervision of Dr. Alshakim Nelson - one of the top-class researchers in 3D and 4D printing of hydrogels. The final goal is that during the third year of the fellowship, under the guidance of Dr. Haritz Sardon at the University o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European school of neuroimmunology ; the third teaching course-tampere (ESNI COURSE 2002)'.

assistant: **Objectives**

ESNI is a European educational framework in neuroimmunology including scientific board with members from 17 European countries. Part of its program is a yearly teaching course for young researchers in basic and clinical neuroimmunology where they meet top scientists/clinicians as speakers and teachers. The 3rd ESNI course is held in Tampered, Sept. 11. -14. 2002 with 200 participants and 40 speakers/ chairmen. Main topics are Regulatory immune responses in the nervous system", Humeral immunity in neuroimmunology", "Neuroinflammation", and "Neuroimmunopharma-cology". The course is a mix of clinical and basic/ experimental neuroimmunology", within each main topic, thus promoting clinical relevance of basic research as well as transferring experimental results to improve treatment and diagnosis for patients with neuroimmunological disease. It should stimulate and improve research quality and provide additional value by increasing European co-operation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Catalytic Asymmetric C-C bond formation with Organo-Lithium reagents' (2007-2013).

assistant: **Innovation**

Carbon–carbon bond formation is at the hearth of chemistry and the development of new methodology for catalytic enantioselective C-C bond formation continues to be a major challenge for synthesis. After more than 80 years since the introduction of organolithium reagents, no general, highly enantioselective and practical catalytic C-C bond formation with organolithium reagents exists. In preliminary studies, Feringa´s group have recently discovered that simple alkyl lithium reagents (MeLi, n-BuLi) yield excellent enantioselectivities in copper catalyzed asymmetric allylic alkylation. The subject of the project is the development of new methodologies for highly asymmetric catalyzed C-C bond formation using organolithium reagents. In this research project will try to accomplish the catalytic asymmetric allylic substitution with aryllithium reagents, catalytic asymmetric vinylation of allylic halides and the development of other highly desirable transformations (like the asymmetric formation of chiral quaternary centers via allylic substitution or allyllic alkylation with secondary alkyl lithium reagents). The methodology will be explored in a number of challenging transformations outlined above and the catalysts optimized through chiral ligand screening and optimization of reaction parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High performance industrial polymers based on modified starch' to be submitted under Fifth Framework.

assistant: **Abstract**

HYDROSTAR is an integrated European project on the utilization of starch and starch derivatives in high quality , high value industrial polymers and a parallel assessment of the sustainability of such industrial polymers. The project addresses the needs of European society for a more sustainable feedstock base for large volume, high performance industrially useful polymers, used in decorative surface coatings, adhesives, paper coating and chemicals, extruded dermoplastics, superabsorbants and co builders for detergents, by changing the feedstocks of such polymers to more renewable raw materials. This will reduce finite resource consumption, be more environmentally benign as the renewable raw materials present less toxic handling and utilization hazards and provide additional markets for materials from a wide range of European sourced crops such a potato, wheat, maize, barley and oats.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Investigating the recognition of a novel ligand by gamma-delta T cells and the translation of this interaction into molecules for future cancer immunotherapy'.

assistant: **Innovation**

Gamma-delta (gd-)T cells are a fast acting subset of T cells that recognize a wide variety of ligands. In contrast to alpha-beta T cells they are not restricted to classical peptide-MHC antigens. Our preliminary data on a gd-T cell clone shows selective recognition of tumour cells mediated through a novel ligand.The aims of this action are; 1) elucidating the molecular mechanism of the gd-T cell receptor (TCR) recognizing the novel ligand on cancer cells and 2) generating therapeutic agents for cancer cells.A multidisciplinary approach will be used to unveil the interaction of the gd-TCR with its ligand. The gd-TCR and novel ligand molecules will be made using recombinant expression. These proteins will be used to characterize this interaction in detail by determining the affinity and the crystal structure. The results generated in this part of the action will increase the current knowledge regarding gd-T cell ligands.The researcher will reintegrate in his home country using his skills in structural immunology, which he acquired in the Rossjohn laboratory at Monash University in Australia, to address the molecular mechanism of the gd-TCR ligand interaction. Additionally, he will be trained by the host laboratory in in vitro and in vivo immunological assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Energy and carbon food webs of the deep sub-seafloor biosphere' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Vast communities of microorganisms in the sub-seafloor biosphere are responsible for the degradation of deeply buried organic matter (OM) and drive complex metabolic processes of OM mineralization. It remains unknown how the microorganisms subsist at the available energetic limits for life with extremely slow turnover. This project aims to determine the energetic and kinetic controls on the major metabolic processes, in particular the role of small organic acids. These occur in a broad range of concentrations in the pore fluid of recent and old sediments and are key intermediates in the microbial food web. The research will develop and apply new and highly sensitive analytical techniques, including 2-dimensional ion chromatography combined with mass spectrometric detection (2D IC-MS). With new analytical capabilities, combined with measurements of microbial substrate turnover rates, we can analyze both the thermodynamic and the kinetic regulation of predominant microbial processes. In international collaboration, including the molecular biological expertise at the Center for Geomicrobiology, it is the ambitious goal to determine, for the first time, the mean cellular energy flux throughout all biogeochemical zones of a sediment column, from the highly active oxic surface to the deep subsurface and from substrate rich to substrate poor sediments. We will focus on three systems of study: A) Coastal marine sediment of Aarhus Bay, an easily accessible and intensively studied test site. B) The North Pacific where IODP (Integrated Ocean Drilling Program) Expedition 337 will drill two km deep sediment harboring Eocene lignite layers. The low-mature OM encountered here is expected to support diverse microbial communities in spite of the 50 million year age. C) The Baltic Sea wh