RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Restriction of HIV-1 infection in naturally resistant human cells', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The life cycle of retroviruses is closely associated to a number of cellular processes of the host cell. Indeed, retroviruses have specifically evolved to exploit cellular mechanisms to avoid the defence systems of the cell. Conversely, eukaryotic cells have evolved several mechanisms to block the replication of HIV-1 or other related viruses. In contrast to CD4+ T-lymphocytes or macrophages, which are the preferential targets for HIV-1 infection, human placental trophoblast cells are not permissive to cell -free HIV-1 infection. Trophoblast cells hence constitute an important barrier for limiting mother-to-child HIV transmission.The objectives of this proposal are to identify and characterise the mechanisms involved in the restriction of HIV-1 replication in these naturally resistant human cells. The restriction of cell-free HIV-1 infection in human trophoblast cells could be due to a defect in signalling occurring during actin microfilament polymerisation (necessary for the interaction with the transcription complex), a defect of virion intracellular trafficking after entry into the host cell that might lead to a delivery of the virus to a degradation pathway (endosomal or proteasomal pathway) or a direct block at the level of the of the reverse transcription. To study the mechanisms of this specific restriction, the BeWo cell line, derived from trophoblastic cells, will be employed.The stage of the retroviral cycle at which the restriction occurs will be determined by using real-time PCR to detect and quantify early and late retrotranscripts. The project will investigate the colocalisation of virions with endosomal or lysosomal vesicles. The project will also address the existence of a potential intracellular restriction factor. The project should lead to a better un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CellCourier: programmable drug delivery via combinatorial cell targeting and generative design of tailored binding peptides' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

CellCourier aims to revolutionize mRNA delivery by enabling precise cell-type-specific targeting through a data-driven platform that integrates single-cell genomics, computational modeling, and generative AI. Conventional approaches often suffer from off-target effects, leading to unintended side effects. To address this, CellCourier leverages combinatorial peptide binder design to achieve precise cell-type recognition, enabling next-generation delivery modalities such as LNPs or STVs.At the core of CellCourier is a computational pipeline that defines unique surface codes for target cells using single-cell transcriptomic data from the Human Cell Atlas (HCA). This process is enhanced by Nicheformer, a model for predicting cell-cell interactions, and Prophet, a deep-learning model for multi-omics perturbation prediction—both key outcomes of the ERC AdG DeepCell grant. Using these refined surface codes, we apply our all-atom generative model to design peptide binders optimized for high specificity and stability. A competitive binding pipeline, which has shown a threefold increase in hit rates, further refines peptide selection.The process is validated both in silico and in vitro. During the ERC Proof of Concept (PoC) period, we will focus on demonstrating feasibility by targeting the lung using insights from the Human Lung Cell Atlas (HLCA), paving the way for novel treatments for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and lung cancer.Beyond technical validation, we will implement intellectual property (IP) protection strategies, securing patents for advanced peptide binders and their integration into innovative delivery systems. We will also explore commercialization pathways, including spin-off formation and pharmaceutical partnerships for out-lic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bridging the gap to commercialisation of wave energy technology using pre-commercial procurement' (EuropeWave) under Horizon 2020.

assistant: **Objectives**

The global potential to harness the power of ocean waves is huge. Europe has 44% of wave energy patents as well as some of the best resources on its Atlantic coastlines.  Wave energy technology has, however, not yet achieved commercial viability and conventional public technology innovation support schemes have had only limited success.  Convergence/consolidation is needed to deliver the technology the market requires.  Without this, investors and industrial developers will not have the confidence to engage with the sector and help make it a significant contributor to the future low carbon energy mix.EuropeWave builds on the success of the regionally funded PCP programme known as Wave Energy Scotland (WES), set up in 2014 and expands this concept to the European level as mandated by the SET Plan Implementation Plan for ocean energy.  WES will be the coordinator of the proposed EuropeWave project and lead a ‘Buyers Group’ of public authorities from the UK (Scotland - WES) and the Basque Country (EVE). The consortium is completed by Ocean Energy Europe, the sector’s representative body, who will enable the widest possible engagement with those influential stakeholders able to maximise the environmental, economic and social benefits of wave energy technology for Europe. EuropeWave brings together over €22.5m of national, regional and EU funding to provide the boost to Europe’s wave energy innovation community necessary to transition to commercial viability. This will be achieved by procuring a phased competitive programme of R&D to pull forward those technologies that can demonstrate the best potential to achieve the technical and economic performance metrics that will make them investor-ready.  Approximately 7 technologies are expected to enter the programme via an open O
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Taming Radiative heat Emission with Anisotropic and Time-varying media' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Thermal emission is a fundamental and ubiquitous process of energy and entropy transport, impacting science and engineering in various way. Yet, its stochastic nature, expressed in a broadband spectrum, lack of polarization and directionality, severely limits its control and manipulation.TREAT aims at introducing a novel method for engineering the radiative heat transport and achieving unprecedented dynamical control over the spectrum and the momentum of thermal radiation. To achieve this goal, I propose to combine two classes of emergent materials: time-varying epsilon-near zero (ENZ) media and hyperbolic materials (HMs). The time modulation of ENZ media will allow to overcome the fundamental limits to thermal emission set by the Planck’s and Stefan-Boltzmann’s laws and achieve active control over its properties. While the HMs, will enable to extract and guide the intense thermal radiation confined at the emitter surface, i.e., in its near-field.TREAT objectives address three intriguing questions: i) Can we create a time-varying media with ad hoc time modulation? ii) Can we manipulate thermal emission beyond the Planck’s law using the time-modulation? iii) Can we improve our control of the radiative heat flow in the near-field? Answering these questions requires the combination of expertise in nanophotonics and ultrafast science and perfectly suits my scientific profile. TREAT specifically targets the thermal emission engineering in the transparency window of Earth atmosphere, relevant for radiative cooling, and the development of novel coherent thermal sources in the THz range. TREAT will provide a fundamental advance to our understanding of thermal fields, beyond fluctuational electrodynamics, and a novel method for engineering the radiative heat flux, anticipating s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The european union's common foreign and security policy : transparency and effectiveness', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Until recently, the debate about the EU's capacity to establish itself as a credible actor in foreign affairs and the discussion over the legitimacy and transparency of supranational decision-making progressed mostly in isolation from each other. Yet, the more central institutions deal with foreign and security matters after the Kosovo conflict and the more they venture into the heartland of the nation-state, the more salient the question of legitimacy and participation becomes. The controversy over the restriction of access to Council documents in the area of foreign and security policy points to emerging research agenda, which combines both perspectives. However, many contributors to this de-bate assume an inevitable trade-off between fully informing civil society and the capacity of political actors to reach decisions and implement effective policies. Hardly explored is the contrary argument namely that effective, stable and legitimate decision-making mechanisms depend on the evolution of intermediary structures for transnational opinion formation. The proposed research project seeks to bring these strands of debate together by looking at the interrelationship between decision-making effectiveness and transparency in the field of the EU's foreign and security policy. It studies how the EU's decision-making for a deal with selected security issues and examines the extent to which these debates are reflected in the coverage of German, French and British media products. The projects aims to fill research gaps both in the area of foreign policy analysis and democracy theory. The most obvious contribution is to enhance my credentials for a career in academia through publications in international journals. After completing the two years as a post-doc at CEPS, I will be mor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Identification, characterization and functional analysis of novel genes involved in early brain development'.

assistant: **Objectives**

A considerable amount of work has been done in recent years on the genetic control of mammalian central nervous system (CNS) development. However, our knowledge of CNS development in general and of rostral CNS specification in particular still remains quite fragmentary.  The proponents set out to adopt a novel methodology based on a recetly devised differential screening technique, to help elucidate some of the molecular mechanisms underlying further subdivision and differentiation of primary brain structures during midgestation brain development. The aim of the present project is to identify, isolate and analyze novel genes involved at various levels in early brain development, and define their role in normal ontogenesis, and in mutants emerged from the mouse stock or generated by homologous recombination. Our search will not be restricted to genes encoding positional or early patterning information. Instead, the proponents plan to extend our investigation to genes governing various cellular processes. To identify genes displaying restricted, brain-specific or stage-specific expression patterns, the proponents will utilize an updated PCR-based cDNA fingerprinting protocol to analyze tissues obtained from various areas of the brain during early development. The proponents are going to compare patterns obtained from telencephalic vesicles at E10.5 and later stages (temporally restricted expression), as well as patterns from anterior (prosencephalic) and more posterior (mesencephalic) structures at E12.5 (spatially restricted expression). Differentially expressed clones will be sequenced and sequences aligned to online databases through different algorithms (BLAST, FASTA). Six-frame conceptual translations of nucleotide sequences will be analyzed for their coding ability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Experimental investigation of CO2 solubility trapping in heterogeneous 3D porous media' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Atmospheric CO2 contributes to 2/3 of the Earth’s global warming by greenhouse effect. Storing CO2 in deep geological formations is the main mitigation measure currently available. ExpeCO2SolTrap addresses solubility trapping (ST), a trapping mechanism of CO2 in dissolved form within the resident brine of the subsurface porous medium, which allows storing CO2 perennially by gravity. ST has been studied extensively in the last 10 years. But numerical studies cannot account for the pore scale heterogeneity of the flow, while most experiments cannot provide a full measurement of the system’ evolution (in particular its dissolution flux). Recent ground-breaking experiments by the host group and secondmend group of ExpeCO2SolTrap have shown that the growth of the instability is orders of magnitude faster than that predicted by a Darcy scale numerical simulation of the experimental process, due to coupling beween the gravitatitional instability and the heterogeneity of pore scale flow. This effect has been hitherto ignored in the literature. Furthermore, the impact of Darcy scale heterogeneity has hardly been studied, in particular not experimentally. ExpeCO2SolTrap proposes to (i) extend the experiments developed in the host group and secondment group to allow for pore scale measurement of fluid velocities three-dimensional (3D) granular porous media, in order to fully understand the aforementioned coupling, and (ii) to study the impact of Darcy scale (e.g., permeability/porosity) heterogeneity of the medium experimentally in granular porous media as well as in 3D-printed porous media of controlled heterogeneity. Two experiments, both relying on refractive index matching of the flowing liquid to the solid phase, but using respectively analogue fluids and dissolved CO2, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'BENE Innovation Internationalisation services 2020-2021' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project aims at offering specific innovation services to 2 different groups of SMEs based in the Brussels Capital Region:- the SMEs beneficiaries of the H2020 European Innovation Council (EIC) Pilot and its funding schemes on the one side, and- the SMEs having a high potential for growth and internationalisation by the enhancement of their innovation management capacity on the other side.These services will be an integral part of the Enterprise Europe Brussels services and will be provided in the frame of a sounded client's journey approach, in line with the company's life cycle.Although for the beneficiaries of the H2020 Enhanced European Innovation Council Pilot funding schemes the proposer depends on the number of successful SME granted and notified by EASME, a funnel approach will be adopted for both groups of SMEs in order to have an upstream estimation and selection of the SME potential existing in the region.This funnel and selective approach will also take into consideration the permeable frontiers which divide one SME group from the other, in the light of the innovation needs and capacities existing at a given time of the SME lifecycle.The service provision for Group 2 will be ensured via a structure process, relying on a contest approach, SME pre-selection, set-up according to a predefined methodology, which relies on ad-hoc tools (and based on 9 criteria) and methodologies, designed with the aim to select only those SMEs with capacity, clear intent and ambition to benefit from the innovationmanagement assessment.In function of the score obtained in the different criteria, the SME will be selected (or not) to benefit from the innovation management capacity assessment held with one of two retained tools, both complaint to EU standard CEN/TS 16555-1 “Innovat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Portable Nano-Particle Emission Measurement System' (PEMs4Nano).

assistant: **Innovation**

The PEMs4Nano project (P4N) addresses the development (based on current direct injection gasoline engines) of measurement procedures down to 10nm, providing a contribution to future regulation on particle emissions, in particular in real driving conditions. The activities planned in the project will also support the understanding, measurement and regulation of particle emissions below 23 nm (with the threshold of at least 10 nm). Societal concerns for the environment include both fuel consumption and noxious emissions, as well as the awareness that meeting CO2-goals with newest technologies may also lead to the emission of smaller nanoparticles that are undetected by current certification procedures. Hence P4N has the goal to develop measurement procedures that are robust and reliable for both the development of the new engine technologies, as well as serving as a solid basis for new regulations. This has the advantage of establishing a solid content link between development activities and regulation. Two complementary measurement systems will be optimized for use in the development laboratory and for mobile testing based on current technologies. Given the numerous parameters associated with the engine (combustion and exhaust systems) technologies and measurement procedures; physico-chemical and data-driven simulations combined with optimization is proposed to establish valuable correlations between measurements made in the development laboratory and thus finally those measured on the road.PEMs4nano thus proposes a two path approach that connects tailpipe measurements with the origin and the evolution of the particles, resulting in a seamless approach from the laboratory to the field test capabilities. Investigations of particle characteristics (incl.composition, size a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Leveraging Small Demethylase inhibitors for Autism Spectrum Disorder' (LSDiASD) targeting Horizon 2020.

assistant: **Abstract**

Duplication of chromosome region 7q11.23 (7Dup), comprising 26-28 genes, is one of best characterized copy number variations (CNV) causing Autism Spectrum Disorder (ASD), a very prevalent neurodevelopmental condition affecting more than 1% individuals worldwide, and for which no effective treatment is available. Despite the remarkable consistency of core ASD symptoms (impairment in language and sociability along with stereotyped behaviours), over 400 causative genetic lesions have been thus far identified for ASD, splitting it de facto into an aggregate of rare and highly penetrant genetic diseases. In turn, the convergence of symptoms grounds the hope that few paradigmatic syndromes may yield generalizable therapeutic inroads across the autistic spectrum. 7Dup is a case in point since it is symmetrically opposite to Williams Syndrome, a condition caused by 7q11.23 hemideletion and featuring symmetrically opposite phenotypes in language and sociability, thus offering unique opportunities to dissect the dosage-vulnerable circuits that affect language competence and sociability. Specifically, convergent evidence points to transcription factor GTF2I as the key gene underlying the cognitive/behavioural traits of 7Dup.  Within my ERC-Consolidator project DISEASEAVATARS we discovered that increased GTF2I dosage represses key genes involved in intellectual disability, autism and neuronal function by associating with lysine demethylase 1 (LSD1), a key chromatin modifier, and found that LSD1 inhibition rescues GTF2I-dependent alterations. Therefore, we now wish to establish in vivo proof of concept for the efficacy of novel LSD1 inhibitors in rescuing cognitive-behavioural deficits in relevant ASD mouse models recapitulating GTF2I CNV, developing an adequate business plan and in