RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing a web-based sexual health support program (AURORAS) for urogenital cancer survivors' (AURORAS) targeting Horizon Europe.

assistant: **Abstract**

Urogenital neoplasms, common in middle-aged patients, cause pelvic pain and sexual dysfunction. limited access to specialized services for urogenital cancer survivors (UGCS), necessitating alternative ways. Using a mixed-methods design and participatory design approach, this project will integrate 3 studies and aim to develop a web-based sexual health support program (WBSHP) based on survivors’ unmet psychosexual needs and to determine its acceptability, feasibility, and preliminary efficacy in managing pelvic pain and sexual function difficulties, ultimately intended to promote pelvic, mental, and sexual health and QoL in UGCS and their partners. Study 1 is a systematic literature review, following PRISMA guidelines, and will inform studies 2 and 3. Aims to summarize existing literature on online and e-mental and sexual health care services for promoting pelvic, mental, and sexual health of UGCS. Study 2 is a qualitative thematic analysis, conducted via in-depth interviews with a group of UGCS and their partners with maximum variation and focus groups with health care providers to explore the impact of UG cancers on survivors’ QoL and their unmet psychosexual care needs and to develop an evidence-based intervention program, integrated with the systematic literature review results, tailored to their needs. Study 3 is a pilot study assessing the acceptability, feasibility, and preliminary efficacy of a co-developed WBSHP intervention (AURORAS) among UGCS and their partners. Eligible participants, recruited from 3 research sites in Iran, after ethical approval, informed consent, and pre-test assessment will be randomized to either the experimental group receiving intervention (N = 30) or the waiting list group receiving treatment as usual (N = 30). Mid-test, post-test ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'All Optical Manipulation of Photonic Metasurfaces for Biophotonic Applications in Microfluidic Environments'.

assistant: **Concept**

The current trend in biophotonics is to try and replicate the same ease and precision that our hands, eyes and ears offer at the macroscopic level, e.g. to hold, observe, squeeze and pull, rotate, cut and probe biological specimens in microfluidic environments. The bidding to get closer and closer to the object of interest has prompted the development of extremely advanced manipulation techniques at scales comparable to that of the wavelength of light. However, the fact that the optical beam can only access the microfluidic chip from the narrow aperture of a microscopic objective limits the versatility of the photonic function that can be realized.With this project, the applicant proposes to introduce a new biophotonic platform based on the all optical manipulation of flexible photonic metasurfaces. These artificial two-dimensional materials have virtually arbitrary photonic responses and have an intrinsic exceptional mechanical stability. This cross-disciplinary project, bridging photonics, material sciences and biology, will enable the adoption of the most modern and advanced photonic designs in microfluidic environments, with transformative benefits for microscopy and biophotonic applications at the interface of molecular and cell biology.


**Keywords:** Photonic metasurfaces, Optical tweezers, Microfluidics, Biohphotonics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Adaptation of existing wind turbines for operation on high wind speed complex terrain sites; kWh cost reduction' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives  To examine the total design envelope criteria of existing selected Wind Turbines for complex terrain operation (Stall 100kW-600kW, Pitch 225kW-500kW, Variable Speed 100kW-450kW, and Teeter 1000kW concepts) in relation to the IEC-1400-1 standard, the wind climate and the complex terrain wind structure; and to investigate the potential for increase in WT energy production and/or decrease in loading that can be attained through feasible WT adaptations; i.e. to investigate the potential ranges and means of cost reduction for the wind produced electricity in very high wind speed complex terrain sites. To fully investigate the newest and state of the art rotor designs for selected Stall and Pitch WTs operating on highly complex terrain sites with very high wind speeds and to examine the possibility of control parameters optimization for the Stall, Pitch, Variable Speed and Teeter WTs for the same sites, with the objective to increase WT energy production and/or decrease loading. To implement the findings of the R&TD work on selected operational Stall, Pitch and Variable Speed WTs (construction, installation and operation of the new rotors and possibly optimized controller parameters) operating on highly complex terrain sites exhibiting high wind speeds and to operate the adapted machines for a minimum of one year. To fully quantify and verify the performance of the adapted Stall, Pitch and Variable Speed WTs through detailed wind, load, power and machine condition measurement programs on the adapted WTs and to provide definite conclusions on the kWh cost reductions attainable.  Technical approach  The project will integrate all relevant information gathered within the previous complex terrain oriented projects where the differences between the complex and flat ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Automatic Polyp Detection System' (MagentiqEye) under Horizon 2020.

assistant: **Objectives**

The World Cancer Research Fund estimates the colorectal cancer to be the third-mostoccurring form of cancer around the world. In 2012, more than 1 Million people werediagnosed with colorectal cancer. These incidences of colorectal cancer have boosted demandfor their diagnostics worldwide. In fact, colon cancer screening has increased greatly in firstworld countries with mature health care delivery systems. Despite this progress the problemof undetected or missed polyps during colonoscopy procedures remains a significant problem:about 8 -10% of the CR cancer cases, resulting in more than 44,500 of preventable cancer inEurope annually. MagentiqEye has developed an Automatic Polyp Detection System (theAPDS) which uses mainly Deep Learning and Computer Vision techniques in order to detectthe polyps which appear on the physician screen during the test. APDS is an AI system whichworks as additional eye, helping doctors to detect polyps. This decision support system canimprove the quality and performance (less miss-rete) of the colonoscopy test, having a highimpact in the prevention of cancer. MagentiqEye seeks funding to conduct a feasibility studyto prove technical and commercial viability, conducting an analytical exercise to position theproduct. The objective is to test the economic viability of the system among a larger pool ofpotential clients (user-acceptance), and to assess if the chosen commercialisation approachwill be conducive of the projected growth on the European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigation of the electronic properties of nanostructures at the atomic scale by means of low temperature scanning tunneling microscopy/spectroscopy in ultrahigh vacuum conditions'.

assistant: **Concept**

The main goal of the research project that I propose for the next three years is the study of the electronic properties of nanostructures at the atomic scale. The investigation will be performed by means of low temperature scanning tunnelling microscopy/spectroscopy in ultrahigh-vacuum environments (UHV-LTSTM), a unique technique which allows the study of these electronic properties in a local way with atomic resolution. Thanks to this technique it will be possible to get the local electronic information of the nanostructures with ultimate energy resolution (<1meV) and also to modify the systems in a controlled way by direct manipulation using the STM tip. This will open the possibility to selectively modify the local environment of the nanostructures to study and also to create new nanostructures using as elemental building-blocks atoms and/or individual molecules. The investigation will be structured in three main research lines: On one side the electronic properties of nanostructures electronically decoupled from the substrate by means of ultrathin insulating films will be studied Two main kind of nanostructures will be examined; bidimensional metallic films and molecules both in single and self-assembled arrangements. In a second line these same nanostructures, now adsorbed on epitaxial graphene, will be investigated. Special emphasis will be put in the influence of the Dirac quasiparticles of graphene in the electronic properties of the nanostructures and also in understanding and/or controlling how the adsorption of these nanostructures locally or even globally modify the electronic properties of graphene itself. The third research line will be focused on the study of phase transitions in the metal semiconductor systems Pb/Si(111), Pb/Ge(111) and Sn/Ge(111) at 4K.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Biocatalytic membranes for micro/nano plastic degradation within waste water effluents'.

assistant: **Objectives**

The universal use of different types of plastic-based materials as new products to meet the insatiable global demands of the 20th century has had an unprecedented impact on our evolution as a society. Unfortunately, micro- and nano-plastics are now ubiquitous in marine and freshwater environments, as well as terrestrial ecosystems, where they act as a source of highly detrimental toxic chemicals that negatively affect the environment and human health by interacting with terrestrial organisms that mediate ecosystem services and functions, such as soil dwelling invertebrates, terrestrial fungi and plant pollinators. It is our duty as scientists to provide immediate and appropriate solutions to control the fate and reduce the effects of micro/nano-plastics on our planet.BMRex will develop entirely new concepts for micro/nano-plastic removal from household and industrial waste water effluents by validating a novel biocatalyst-based membrane reactor technology to degrade plastic waste avoiding further damage. The consortium will produce, test & optimize biocatalytic membrane reactors based on porous inorganic scaffolds functionalized with ionic liquid materials modified for biofouling resistance, plastic affinity and controlled attachment of plastic-degrading enzymes. Interchangeable enzyme species will permit a precise control of stepwise catalytic processes enhanced with artificial cytosis, maximizing activity and stability of the biocatalytic reactions. BMRex will also evaluate the economic and technological viability of this novel technology. With its unique integration of scientific approaches, competences and resources, BMRex has the potential to open up an entirely new technological field.In the long term, this project aims to enable an in situ, more efficient and saf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Decoding Requirements for Infiltration of T ceLLs into solid tumors'.

assistant: **Objectives**

Cancer immunotherapies that leverage T cell activities are transforming cancer treatment. Currently, enormous effort has been devoted to empowering T cells to recognize and attack tumor cells. In contrast, the trafficking of T cells into tumors, a crucial prerequisite and limiting factor for effective T celltumor cell interactions, receives relatively less attention while at the same time being poorly understood. This is due to the complex and dynamic nature of T cell trafficking and the lack of model systems that allow function-based systematic investigation of the specific process.  This proposal integrates innovative functional genomics into physiologically relevant models that recapitulate two essential steps in the migration of effector T cells into tumors to investigate i) chemokine production in the tumor microenvironment (TME) and ii) chemotactic infiltration of T cells into tumors. Here we focus on one of the most devastating cancers, pancreatic ductal adenocarcinoma (PDAC), because it poses considerable physical and biochemical barriers that restrict the access of effector T cells to tumor cells and substantially resists all available therapies.We will 1) elucidate the (co)regulatory mechanisms of the expression of chemokines that direct T cell recruitment and exclusion. In parallel, we will 2) develop model systems to systematically reveal cell-intrinsic determinants in T cells that influence their capability to infiltrate tumors. Finally, we will 3) evaluate whether pharmacological or genetic targeting of the modulators of T cell trafficking improves T cell-based cancer immunotherapies. Collectively, this project will deliver fundamental insight into the mechanisms that regulate T cell trafficking into tumors and may yield novel strategies to broaden or incr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Green Solar-to-propellant Water Propulsion' to be submitted under Horizon Europe.

assistant: **Abstract**

Similar to terrestrial photosynthesis, whereby plants convert solar energy into chemical energy through the capture of light energy, Green SWaP project seeks to harness this potentiality in space by converting water into highly valuable propellants, specifically hydrogen peroxide and hydrogen. Green SWaP will prove and validate a technology that will use solar energy to produce propellants from water for in-space green propulsion. It will be a crucial building block to enable innovative green propulsion solutions for in-space mobility, resulting in low-cost and eco-friendly innovative concepts. It is a novel approach, never developed for in-space mobility. Studies exist for terrestrial applications, but the space environment introduces additional constraints and dedicated challenges that the project will try to solve. The new technologies, based on innovative chemical processes, will harvest solar power to enable green propulsion. It is a plausible methodology because underlying technological concepts of producing/concentrating/storing hydrogen peroxide and hydrogen using solar energy have been proven (separately) even though for different constraints and conditions of use than in-space applications. Moreover, the combination of hydrogen peroxide and hydrogen has never been investigated in detail and the utilization of hydrogen for solar thermal propulsion is theoretically proven to be the most promising but it has never been developed as technology. The combination of these technologies will drastically increase future spacecrafts’ capabilities, facilitating renewable and self-sustainable in-space mobility. Optimisation concerning the quality and quantity of hydrogen peroxide and hydrogen produced onboard and the efficiency improvement will be fully explored.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engineering Vascularized Tissues' to be submitted under Seventh Framework.

assistant: **Abstract**

Vascularization, the process in which new blood vessels assemble, is fundamental to tissue vitality. Vessel network assembly within 3D tissues can be induced in-vitro by means of multicellular culturing of endothelial cells (EC), fibroblasts and cells specific to the tissue of interest. This approach supports formation of endothelial vessels and promotes EC and tissue-specific cell interactions. Such EC-dependent tube-like openings may also form the basis for improved media penetration to the inner regions of thick 3D constructs, allowing for enhanced construct survival and for effective engineering of large complex tissues in the lab. Moreover, our own breakthrough results describe the beneficial impact of in vitro prevascularization of engineered muscle tissue on its survival and vascularization upon implantation. These studies have also demonstrated that implanted vascular networks of in vitro engineered constructs, can anastomose with host vasculature and form functional blood vessels in vivo. However, the mechanisms underlying enhanced vascularization of endothelialized engineered constructs and implant-host vessel integration remain unclear. In this proposal, our research objectives are (1) to uncover the mechanisms governing in vitro vessel network formation in engineered 3D tissues and (2) to elucidate the process of graft-host vessel network integration and implant vessel-stimulated promotion of neovascularization in vivo. In addition, the impact of construct prevascularization on implant survival and function will be explored in animal disease models.  While there are still many challenges ahead, should we succeed, our research could lay the foundation for significantly enhanced tissue construct vascularization procedures and for their application in regenerat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New Assessment Tools for CROSS-CURRICULAR- COMPETENCIES in the Domain of PROBLEM SOLVING' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

One of the biggest challenges to educational research and policy is providing relevant information regarding the education system's outcome at different levels. Student outcome indicators are of special interest as obviously this information is a primary criterion for different activities such as teaching, assessment, quality improvement programs, evaluation studies, and steering (as expressed by the French word pilotage ) the educational system. In the last few decades a major effort was exerted at the international level (e.g. IEA, OECD, EU) to develop student outcome indicators for comparative purposes. The most recent of these enterprises, the Third International Mathematics and Science Study (TIMSS) conducted by IEA between 1994 and 1996, exemplifies the progress that has been made. In the next decade, a major source of information about education will be provided by a recently launched OECD-study in 26 countries (comprising all EUcountries, except Portugal). This study addresses student achievement indicators in the fields of Reading Literacy, Mathematics and Science, together with indicators with respect to Cross-Curricular Competencies (CCC). In the field of CCC special emphasis has been given to Problem Solving as a very central competence. It must be noted that European influence on the design of similar studies has been rather weak in the past, thus leading to some frustration both within the political and the scientific communities in EU countries. Above all some typical EU problems of a multicultural, multilingual society have not been sufficiently addressed. All EU countries (and other European countries) participating in the OECD Data Strategy recognise that a common European effort in different parts of the study is highly desirable. Consistent with this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Small molecule heparanase inhibitors as anti-metastatic cancer drugs'.

assistant: **Concept**

The Heparanib Proof-of-Concept project aims to establish the feasibility of our unique small molecule heparanase inhibitors as drug candidates for the treatment of metastatic cancers. To strengthen our science case (experimental development A) and by building on our in vivo data in mouse models for metastatic breast cancer, lung cancer and multiple myeloma, we will (A-I) design a suitable route of synthesis to prepare sufficient quantities of clinical grade material; (A-II) synthesise reference compounds; and (A-III) perform initial pharmacokinetics/pharmacodynamics (PK/PD) studies. With the aim to prepare for the establishment of a spin-out biotech company (business development B) to take our leads towards the clinic we will (B-IV) strengthen our intellectual property (IP) position; (B-V) perform an extensive analysis of the anti-metastatic cancer drug market; and (B-VI) prepare for commercialisation by consolidating the results in an investor-ready business plan to develop and commercialise our anticancer drug candidate.