RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards the prevention of aminoglycoside antibiotic-related deafness' (DesignerAntibiotics) under Horizon 2020.

assistant: **Objectives**

Aminoglycosides are critically important antimicrobials used in the treatment of life-threatening infections. A major drawback of usage is hearing loss caused by irreversible damage to the inner ear (ototoxicity). Ototoxicity occurs in ~20% of patients and ~100% of patients with the m.1555A>G mitochondrial DNA mutation. The largest EU patient group exposed to aminoglycosides are children in neonatal intensive care and the effect of hearing loss during infancy is particularly profound as it impedes language acquisition. Thus, there is an urgent need to develop safer aminoglycoside antibiotics. Ototoxicity limits usage despite the antibacterial potency and low incidence of drug resistance provided by this class of antibiotics. Economically, the annual EU cost incurred by drug resistant infections amounts to €1.5 billion, and the cost of hearing impairment is estimated to be €78 billion. Moreover, 25,000 EU patients die annually as a result of infections caused by resistant bacteria and 22.5 million suffer from hearing impairment, with 2 million profoundly deaf. Stanford research recently published in the Journal of Clinical Investigation has shown that it is possible to chemically modify aminoglycosides to diminish ototoxicity while maintaining antibacterial activity. Through a novel collaboration between Stanford and University College London (UCL), the aim of this research is to use a results-guided drug design approach to develop the next generation of safer aminoglycoside antibiotics. For this work, the candidate will have access to 15 novel patented aminoglycoside compounds, crystallography data, murine in vitro and in vitro models of ototoxicity, and a rare biobank of cells from patients with the m.1555A>G mutation. This work will build upon the candidate’s Distinct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spanish Presidency Conference: MSCA DIverse REsearch Careers to Tackle Global Challenges' (2021-2027).

assistant: **Innovation**

The project MSCA DiReCT-GC (DIverse REsearch Careers to Tackle Global Challenges) aims at organizing the MSCA conference with the overarching objective of fostering the connection between science and policy making to better address societal challenges. The event, organised by the Spanish Foundation for Science and Technology (FECYT), on behalf of the Spanish Ministry of Science and Innovation (MCIN) will be held November 14th and 15th 2023 in the city of Toledo, in the University of Castilla-La-Mancha (UCLM) premises.With the aim of raising the visibility of MSCA and establishing a link with the policy agenda, the conference will address ongoing initiatives in the realm of science for policy, the contributions of MSCA to societal challenges from a global perspective to a local impact, and the future of diverse and inclusive research careers, including professional paths to support evidence-based policy making. The event will also offer enough space for interactive debates on the MSCA main features with the aim of contributing to the upcoming 2025-2027 Work Programme.  Finally, a recognition of the MSCA best projects in terms of science for policy contributions will be present in the MSCA Awards Ceremony.


**Keywords:** Marie Sklodowska-Curie Actions, Conference, Mobility, Career Development, Science for Policy, ERA Policy Agenda, Global Challenges, Inclusiveness, Spanish Presidency of EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Physical design automation on mixed semi-custom arrays' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- Increase the know-how necessary to design mixed analogue-digital ICs at low cost and fast turnaround through the use of mixed-mode arrays and standard cell methodologies.- Acquire a full control of the design process, from system to chip, and from high-level specificationto low-level physical design.- Take advantage of the advance availability of full-featured, low-cost, physical IC design automation tools from EDA Solutions and Snake Technologies: GATESNAKE and CELLSNAKE.- Develop and evaluate a new analogue-digital IC design flow on PC, including tools well known on the market, and newer tools from EDA/Snake.- Develop two mixed analogue-digital ICs to be integrated in the next generation of Prinsys products: one is a RF emitter in the range 125 kHz to 6 MHz, and the second is an AM demodulator coupled with a manchester-type decoder.- Evaluate typical user expectations for IC physical design tools, and tune functionality and features accordingly. Set up a support and maintenance procedure.Electronic systems for contactless identification use radio-frequency (RF) and infra-red (IR) transmission techniques to exchange information between a fixed, controlling device and a mobile, controlled device (typically an identification badge). These systems dramatically benefit from integration on a single chip, for economical, reliability and confidentiality reasons. In order to limit costs for medium-volume production, a mixture of full-custom and mixed-mode semi-custom solutions have been selected. Thanks to the availability of new, low-cost, physical design tools for gate arrays and standard cells provided by Snake Technologies (formerly EDA Solutions): GATESNAKE and CELLSNAKE, Prinsys is able to control the whole design flow of the ICs of its systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Greenland arctic shelf ice and climate experiment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

A radical change occurred a decade ago in Arctic atmospheric circulation. Associated with a reversal of the Arctic Oscillation (AO). This resulted in changes of sea ice motion and characteristics, most manifest in the critical region north of Greenland. GreenICE takes advantage of winter ice camps in this region. Seabed sediment cores will map the climatic record, and a multilevel study of sea ice - in situ thickness and roughness measurements; buoys for ice dynamics, and satellite coverage - will be performed. An existing sea ice model will be improved and used to extend regional results to basin scales. The aim is to form a complete picture of ice response to an AO reversal, matching this to concurrent climate change. By reference to the regional climatic record for the past 2000+ years, we thus aim to understand the nature and magnitude of Arctic sea ice response to observed climate variability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Visualising Engineered Landscapes: an archaeological approach to unlock environmental resilience and sustainability in antiquity' (VEiL), addressing dissemination and exploitation.

assistant: **Impact**

Contemporary anthropogenic landscapes were shaped by centuries of human action. Land surveying and division were the first forms of widespread landscape engineering performed by pre-industrial societies. Among those, the most complex was unquestionably the Roman Centuriation, which still characterise the rural landscapes of many European countries. Notwithstanding its impact on modern European land organisation, the principles underlying the design approach used by Roman land commissioners are still largely ambiguous. The proposed project thus aims to illuminate the process of landscape engineering undertaken in antiquity by the Roman surveyors and contribute to the discipline of landscape engineering by injecting a new body of evidence into the debate about past land division and design in order to inform models of sustainable practice for contemporary landscape management.The project integrates archaeological, historical and geospatial information to investigate the forms, impact and endurance of complex engineering on the landscape of Aquileia (Italy), a major city of the Roman Empire. Imprinted with the Roman 'spatial signature', the Aquileian countryside provides an unparalleled opportunity to expand our current understanding and perception of the origins and advances of landscape engineering and its efforts to build sustainable responses to long-term environmental and socio-economic pressures. To achieve its research agenda, this study will develop new methods based on Artificial Intelligence for digitally identifying, collecting, integrating, managing and sharing diverse spatial and archaeological data that are key for the identification of the centurial system elements where they are no longer readily identifiable and will apply a novel approach for defining mod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Community noise research strategy plan (CALM)' (CALM) targeting Fifth Framework.

assistant: **Abstract**

The CALM Network aim to establish and coordinate a Community Noise Research Strategy Plan defining the proper steps towards noise emission reductions within the EU in the domains of air traffic, road and rail transport, marine technologies and outdoor equipment. This Strategy Plan will be based on reports from expert Noise Working Groups (appointed by the European Commission) and in cooperation with relevant industry sectors, research institutions and interest organizations. The participants in the network are chair of co-chair of the Noise Working Groups (except the co-coordinator). The Community Noise Research Strategy Plan will propose research requirements according to relevant standardization, economic and social measures, strategies and visions for future achievement of acceptable noise emission levels for the EU population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control of proliferation and cell shape in Drosophila' (2002-2006).

assistant: **Concept**

How the size and form of an organism are controlled are two fundamental questions in developmental biology. The imaginal eye disc of Drosophila melanogaster provides an excellent model tissue to analyse both of these phenomena at the same time. This project has two goals. First, to analyse how the intercellular signals that drive eye development integrate to regulate proliferation. Second, to use a similar approach to elucidating how cell shape is regulated by signals. The particular development of the eye disc provides the key that makes these two questions amenable to analysis.A wave of development sweeps from posterior to anterior across this imaginal disc and an indentation known as the morphogenetic furrow (MF) marks the front of this wave. Cells just anterior to the furrow are arrested in G1 phase in a non-differentiated stage. Soon after the passage of the MF, most cells undergo a single round of mitosis, the second mitotic wave (SMW), and start to differentiate. Not only do cells go through this coordinated cell cycle around the MF, they also undergo dramatic changes in cell shape: as they enter the MF they shorten in the apical/basal axis and constrict their apical surfaces. Once the MF has passed they return to more normal columnar epithelial morphology.The MF movement is controlled by well- characterised intercellular signals and I hope to find the functional link between the reception of these signals and cellular events described above. Specific questions will include how these signals control proliferation and cell shape in the region around the MF. What other genes, like eye pre-pattern transcription factors, are involved in the cell cycle control? What cell adhesion molecules are responsible for the cell shape changes, and how is actin polymerisation con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An autonomous, self-driven robot system to improve the mobility and integration of people, creating a more equal and accessible society' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Smart and inclusive mobility is important in many societal contexts. People with reduced mobility are proven to be one of the most neglected groups in society. They experience accessibility problems and difficulties in performing routine tasks on a daily basis. For example, what may be a simple activity to many, such as shopping, can become very complex and time consuming.The WiiGO is an autonomous and self-driven device that follows a specific user or can be programmed to move independently. The robotic system uses the latest technology in image recognition, machine learning and artificial intelligence so that it can track users while identifying and avoiding any obstacle in its way. By functioning as an autonomous shopping cart, the developed solution supports users with reduced mobility, reducing their reliance on other people to help them with day-to-day activities. Given its autonomy and its capacity to guide and record information, the WiiGO is a flexible system that can lend itself to many applications.Within the overall project, Follow Inspiration intend to optimise the functional design, conduct pilot tests, demonstrating the WiiGO in different retail environments, and fully establish the commercialisation strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Resolving subglacial properties, hydrological networks and dynamic evolution of ice flow on the Greenland Ice Sheet' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Greenland Ice Sheet is losing mass at a growing rate and has since 2010 caused sea level rise of 1 mm/year. The most severe changes occur in the drainage basins of marine-terminating glaciers, which flow rapidly and drain 88% of the ice sheet. The latest report by the Intergovernmental Panel on Climate Change concluded that the widespread acceleration of these glaciers in recent years was a response to interaction with the ocean and unrelated to basal lubrication of ice flow; yet, observations have since shown that many of these glaciers respond to the growing volume of surface meltwater, which reaches the bed when surface lakes drain. This basal lubrication mechanism is unknown, but exhibits contrasting control on ice flow at the coast and in the interior where surface melting increasingly forms lakes. This lack of vital knowledge is a major source of uncertainty in the current generation of ice sheet models used to predict sea level change.The fundamental goal of RESPONDER is to understand how hydrological networks at the base of the Greenland Ice Sheet evolve over seasons and over multiple years, and how this evolution impacts on ice flow in the interior and at the coast. The project has the following aims:AIM 1 is to identify glaciological ‘hotspots’ and sites for subglacial access drilling and borehole exploration by tracking hydrological pathways beneath Store Glacier, a large marine-terminating glacier in Uummannaq Fjord, using novel geophysical imaging techniques and unmanned aerial vehicles (UAVs).AIM 2 is to observe and quantify the hydrological networks of Store Glacier while measuring basal slip and strain within ice with probes and sensors installed in boreholes drilled at ‘coastal’ and ‘interior’ targets.AIM 3 is to predict the co-evolution of ice flow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Flying companion for floating litter collection' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Plastic pollution is considered one of the most challenging environmental risks globally, and rivers have been identified as a dominant pathway for the accumulation of plastic in the oceans. The Flyflic (FLYing companion for Floating LItter Collection) project addresses this global challenge by deploying a first-of-its-kind robotic platform composed of multiple unmanned aerial robots to effectively collect litter from rivers and canals, thus preventing such litter from reaching our oceans. Chiara Gabellieri will carry out the Flyflic project under the supervision of Prof. Antonio Franchi at the University of Twente (UT), The Netherlands. The project contributes to European strategic priorities (Horizon Europe Mission on healthy oceans, seas, coastal and inland waters) and global strategic priorities (United Nations Sustainable Development Goals). Compared to state-of-the-art solutions, which are boat-like robots or fixed trapping mechanisms, a flying platform can target desired spots, can easily discharge the collected litter, is low cost, and is not hindered by non-navigable spots such as dams and low bridges. The general vision of the Flyflic project will be accomplished through four specific objectives: a novel prototype composed of two physically connected aerial robots and a net to be dragged in the water to collect the litter will be assembled; the dynamic model of the complex manipulation aerial system embedding the water-related disturbances will be computed and a model-based control law designed accordingly; all the components for autonomous functioning will be integrated, especially the control law and state-of-the-art algorithms for object recognition and trajectory generation; finally, a user interface will be created to let a human monitor the task executio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neuronal DNA double strand breaks as novel epigenetic actors: roles in cognition, health and neuro-inflammatory diseases' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cognitive deficits are manifested several years prior detecting any neuronal loss in neurodegenerative diseases or during persistent infections of the central nervous system (CNS). Accumulating evidence show that epigenetic alterations contribute to neuronal dysfunction, as they cause durable changes of the chromatin structure that affect gene expression. In this context, DNA double-strand breaks (DSBs) are now emerging as central regulators of neuronal epigenetics.My recent findings opened innovative perspectives of research. I showed that DSBs are not always associated with neuronal apoptosis, but rather constitute novel epigenetic signals that contribute to cognitive processes. To date, the role of DSBs in pathogen persistence and the mechanisms whereby DSBs affect neuronal function in the course of an infection are totally unknown.  Here, we postulate that perturbations in sensing, production and/or repair of DSBs may underlie the behavioral impairment that is observed in many CNS infectious diseases.Persistent neuronal viral infections, such as Bornavirus or Herpesviruses alter neuronal function, sometimes without overt immune response. The underlying mechanisms may result from episomal persistence of the viral genome in interaction with neuronal chromatin, thereby hijacking the chromatin remodeling system of the host cell, or from the secretion of proinflammatory cytokines. Parasites such as Toxoplasma also persist in the CNS and cause behavioral impairment. Their long-lasting impact on neuronal function may involve the modulation of the epigenome.Here, we propose to analyze the role of DSBs in cognitive alterations that accompany neurological infectious diseases. In particular, we will: 1) characterize the role of pathogens and the associated immune response to n