RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Learning the dynamic statistical folding of bacterial chromosomes' (Learn4DChromosome).

assistant: **Innovation**

The physical organization of bacterial chromosomes is inherently variable, with large conformational fluctuations both from cell to cell and over time. Yet, chromosomes must also be structured to facilitate processes such as transcription, replication, and segregation. A physical description of this dynamic statistical folding of bacterial chromosomes remains largely elusive.  Hi-C experiments probe chromosome organization by measuring average contact frequencies of chromosomal loci pairs. Despite the rapidly expanding database of high-resolution Hi-C data for many bacterial species and conditions, these data are still mainly interpreted on a case-by-case basis and with qualitative or heuristic methods. My goal is to develop a principled unifying approach to infer and analyze the dynamic organization of chromosomes from bacterial Hi-C data. This data-driven approach aims to unravel the dynamic statistical folding of chromosomes  and its impact on functional processes  in growing and replicating bacteria.  We will infer a bacterial chromosome model from state-of-the-art data using learning methods at the intersection of information theory and statistical mechanics. By combining data-driven with mechanistic modelling approaches, we aim to:Decode information contained in Hi-C data by learning both 3D steady-state and 4D dynamic models for the statistical organization of chromosomes. Provide a unifying statistical mechanics analysis of the dynamic statistical folding of chromosomes across bacterial species under both steady-state and replicating conditions. Develop theoretical methods using pairwise and multi-contact statistics to study the topology of statistical chromosome folding.  My research will advance the field by providing a conceptual understanding of the physical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating cancer detection and SURgery Via molecular Imaging' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ambitious aim of this ERC-advanced grant proposal is to develop strategies that will connect cancer detection and surgery via tumor-specific molecular imaging techniques. This will lead to personalized patient-, or even tumor-specific treatment strategies. In addition, it will provide a tool for the selection of patients that, following preoperative (neoadjuvant) treatment, would benefit from additional (minimally invasive) surgery and identify patients who may be treated non-operatively. Fine-tuning the relation between tumor diagnosis, neoadjuvant treatment, preoperative planning and minimally invasive image-guided surgery will likely improve radical oncologic surgery while reducing surgical morbidity in cancer patients.The mechanistic aim of the proposal is to develop an integrated multimodal imaging strategy that will more accurately connect tumor biology with surgical resection approaches via the use of tumor-specific molecular imaging agents. The cornerstone of this approach is the unique clinical translation of tumor-targeted imaging agents that are both radioactive (diagnostic imaging) and fluorescently (surgical guidance) labeled. It is expected that the proposed multimodal imaging agents will allow for a significant improvement of both imaging and surgery strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Making and wearing semi-PRECIOUS stone beads in the Near East and the Nile Valley during the Neolithic: A biographical perspective and microwear approach' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Beyond their symbolic functions, body ornaments offer crucial information to tackle the social organization of the past societies and to address their techno-cultural behaviours. In this sense, PRECIOUS is dedicated to the study of the first semi-precious stone beads in the Near East and the Nile Valley. The major aim is to understand the production and the consumption systems of these beads during the Neolithisation and the emergence of the farming communities (8th-4th mill. cal. BC). Beads discovered in burials from major Near Eastern and Nubian archaeological sites will be analysed through a microwear approach complemented by geochemical analyses. For the first time in the field of stone ornaments, high-precision surface texture analysis will be applied using the technique of the Confocal Scanning Microscopy (CSM) and metrology software. The “biographies” of the archaeological beads (manufacturing techniques, modalities of uses including accidents, repairing or recycling events) will be reconstructed through microtopographic analyses and comparisons with ethnographic and experimental references. A challenging experimental collection of references will be created as stone bead preforms will first document several drilling and finishing techniques, and then be subject to different scenarios of uses. The ethnographic material available are carnelian beads produced by traditional workshops in Yemen and India. To address the place of semi-precious stone beads within the Neolithic societies, the quality of production (levels of technicity) and maintenance will be assessed and statistically compared with well-defined chronocultural contexts and biological data available for the individuals wearing the ornaments (age, sex). The PRECIOUS project will greatly advance the resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The role of non coding RNA in organismal ageing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The DNA damage response (DDR) is a set of cellular events that follow the generation of a DNA damage. We have previously discovered a novel class of small non-coding RNAs, named DNA damage RNAs (DDRNAs), which are necessary for the full DDR activation upon a DNA double-strand break generation. Our preliminary data show that also at damaged/dysfunctional telomeres telomeric transcrips are produced. By using antisense oligonucleotides (ASOs) targeting them, we aim at modulating DDR in cultured cells and in vivo in animal models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel mitochondria-targeted therapies for cancer treatment-induced cardiotoxicity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cardiac toxicity is one of the most frequent serious side effects of cancer therapy, affecting up to 30% of treated patients. Cancer treatment-induced cardiotoxicity (CTiCT) can result in severe heart failure. The trade-off between cancer and chronic heart failure is an immense personal burden with physical and psychological consequences. Current therapies for CTiCT are suboptimal, featuring poor early detection algorithms and nonspecific heart failure treatments. Based on our recently published results and additional preliminary data presented here, we propose that CTiCT is associated with altered mitochondrial dynamics, triggering a cardiomyocyte metabolic reprogramming. MATRIX represents a holistic approach to tackling mitochondrial dysfunction in CTiCT. Our hypothesis is that reverting metabolic reprogramming by shifting mitochondrial substrate utilization could represent a new paradigm in the treatment of early-stage CTiCT. By refining a novel imaging-based algorithm recently developed in our group, we will achieve very early detection of myocardial damage in patients treated with commonly prescribed cancer therapies, long before clinically used parameters become abnormal. Such early detection, not available currently, is crucial for implementation of early therapies. We also hypothesize that in end-stage CTiCT, mitochondrial dysfunction has passed a no-return point, and the failing heart will only be rescued by a strategy to replenish the myocardium with fresh healthy mitochondria. This will be achieved with a radical new therapeutic option: in-vivo mitochondrial transplantation. The MATRIX project has broad translational potential, including a new therapeutic approach to a clinically relevant condition, the development of technology for early diagnosis, and advan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Next-Generation Integrated Energy Services fOr Citizen Energy CommuNities', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

While building on results of recently (or soon to be) concluded EU projects, NEON will undertake coordination and support activities to advance the leveraging technologies and concepts in order to deliver the next-generation integrated energy services for communities, targeted to enhance the life quality of European citizens, while improving the performance of energy system. In this endeavour, NEON will exploit building energy efficiency, renewable energy generation and storage, and demand flexibility to increase energy savings, reduce CO2 emissions, and provide cost savings across sectors. NEON will engage grid stakeholders, service providers and final consumers to establish, in co-creation, the cross-sectoral arrangements and underlying service concepts. NEON will join multi-measure energy efficiency interventions and advanced control capabilities to maximize the positive impact of energy efficiency by improving the building operation performance and make the demand-side flexibility as manageable and procurable resource. NEON will advance the energy efficiency services already available on the market and couple them with other energy services and non-energy benefits, providing an integrated approach to energy generation, storage and consumption management. To enable servitization of proposed concepts, NEON will bring innovative business and contracting models by integrating EPC with P4P schemes, and establish innovative M&V methodology. The concept of Citizen Energy Communities (CECs), as introduced by Directive (EU) 2019/944, will be leveraged to set the legal and business foundations to enable faster market uptake, and facilitate communities, both residential and non-residential, in becoming energy-efficient. The proposed service concepts and business models will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Electron-lattice-spin correlations and many-body phenomena in 2D semiconductors and related heterostructures' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Two-dimensional crystalline materials exhibit exceptional physical properties and offer fascinating potential as fundamental building blocks for future two-dimensional electronic and optoelectronic devices.  Transition metal dichalcogenides (TMDCs) are of particular interest as they show a variety of many-body phenomena and correlation effects. Key properties are: i) additional internal degrees of freedom of the electrons, described as valley pseudospin and layer pseudospin, ii) electronic many-body effects like strongly-bound excitons and trions, and iii) electron-lattice correlations like polarons. While these phenomena represent intriguing fundamental solid state physics problems, they are of great practical importance in view of the envisioned nanoscopic devices based on two-dimensional materials. The experimental research project FLATLAND will address the exotic spin-valley-layer correlations in few-layer thick TMDC crystals and TMDC-based heterostructures. The latter comprise other 2D materials, organic crystals, metals and phase change materials as second constituent. Microscopic coupling and correlation effects, both within pure materials as well as across the interface of heterostructures, will be accessed by time- and angle-resolved extreme ultraviolet-photoelectron spectroscopy, femtosecond electron diffraction, and time-resolved optical spectroscopies. The project promises unprecedented insight into the microscopic coupling mechanisms governing the performance of van der Waals-bonded devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Understanding brain hemisphere organization by leveraging individual differences'.

assistant: **Innovation**

Many human-defining mental capacities recruit an extensive network of brain regions in both hemispheres, yet are dominantly controlled by one side. For example, language activates both halves of the brain, but language impairments are more severe, likely and longer-lasting when that function’s dominant hemisphere is damaged. In spite of being such an important feature of the human brain, hemisphere organization is commonly studied in a fragmented way. Theories about the benefits of hemisphere organization are incomplete, either focusing solely on the dominant side or non-dominant side. Another issue hindering progress on understanding hemisphere organization is that individual differences in hemisphere specialization are ignored, despite being massive. Combined, this led to opposing philosophies for promoting cognitive recovery after one-sided brain damage and one-size-fits-all therapies. HEMIVAR will help resolve these issues through an original integration of advanced neuroscience techniques (MRI and TMS) and sophisticated network-analysis frameworks, that will allow to study hemisphere organization in the intact and disrupted brain holistically. A major conceptual and methodological innovation is the attention to individual variability in hemisphere organization. My project will deliver a novel empirically-validated theory that jointly explains the biological roles of the dominant and non-dominant hemisphere (Objective 1) and will clarify how individual hemisphere dominance interacts with between-hemisphere connectivity (Objective 2). The project's results will constitute a significant advancement of our understanding of the human brain and will generate widely-applicable methodological recommendations for future studies. On top of that, they will serve as a stepping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Meganucleases for Gene Replacement' (MENUG) under Sixth Framework.

assistant: **Objectives**

Genetic diseases can only be truly cured via restoration of defective gene function. Homologous recombination is the ultimate tool for gene replacement, but is limited by low efficiency and reproducibility. DNA double-strand breaks enhance the efficiency o f homologous recombination in vitro dramatically, however for in vivo applications absolute site-specificity is crucial.Engineered, highly specific DNA endonucleases (meganucleases) with programmable specificity are the key to a wider use of homologous recombination in gene replacement. MenuG seeks to develop meganucleases that cleave only at positions of interest in a genomic context with the aim to solve - based on homologous recombination - the main problem in gene therapy: to replace genes efficiently, selectively and reproducibly.Three types of meganucleases will be engineered:- programmed restriction enzymes,- novel or redesigned homing endonucleases,- redesigned Type IIS restriction enzymes.These will be tested for in vitro cleavage specificity, delivery into the nuclei, in vivo cleavage specificity and induction of double-strand break repair by homologous recombination. Promising meganucleases will be tested for gene replacement in Pompe metabolic disease.Concepts for commercial applications will be developed. MenuG is a high-risk project, starting from the engineering of programmable meganucleases to efficient cell delivery and specific action on a defined genetic locus. It has a high impact profile with potentially enormous benefits primarily in the treatment of inherited monogenetic diseases, but in principle also of multigenic disorders, including cancer. Its innovative and visionary concepts are in the spirit of ADVENTURE.MenuG is multidisciplinary (comprising biochemistry, molecular, structural and cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Carbides to Molecules' (Carb2Mol).

assistant: **Concept**

Disubstituted carbon species, specifically carbenes (“CR2”) and their metal complexes, drive innovation across synthesis, catalysis, materials science, and medicine. In stark contrast, the corresponding carbynes (“CR”) and carbides (“C”) remain curiosity compounds or elusive entities. In fact, C1, C3 and to some extent C2 transfer generally remains a pressing challenge in the molecular sciences, while the controlled synthesis of carbon allotropes represents a millenial challenge.  CARB2MOL seeks to achieve this mission by introducing sustainable solid-state materials, namely abundant ionic carbides, as resources for molecules. Solubilized, and thus molecularized, aluminium, calcium and magnesium carbides will serve as long-sought general C1, C2 and C3 building blocks, enabling the synthesis of much-desired molecular inorganic and organic compounds. Specific elusive targets with relevance for synthesis, optoelectronics, and spintronics include super-reductants, carbon(0) allotropes, cumulenes with an odd number of carbon atoms, and nanoclusters. These metal clusters will provide a pioneering entry not only to carbon transfer catalysis but also nitrogen- and phosphorus functional group transfer.While interdisciplinary CARB2MOL relies on solid-state materials, its foundation lies in molecular coordination chemistry. It integrates concepts from organic- and main-group synthesis and leverages advanced spectroscopy as well as quantum chemical predictions. CARB2MOL uncovers vast chemical space by converting affordable and sustainable base chemicals into valuable molecules for high-end applications and even opens avenues to address the alchemists’ dream:  Efficient, mild and bottom-up diamond synthesis.


**Keywords:** Molecular Inorganic Chemistry, Transition Metals, Synthesis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Algebraic groups at the heart of post-quantum cryptography' in the context of a Horizon Europe call.

assistant: **Objectives**

Contemporary public-key cryptography builds its foundations on a handful of computational problems rooted in arithmetic and geometry. The vast majority of deployed cryptosystems rely on two classical problems (computing discrete logarithms, and factoring integers) that would not resist a large-scale quantum computer. Research on quantum technology is accelerating, endangering the world's information systems. New foundations are being proposed by the cryptologic community, promising post-quantum security, but suffering in many aspects from the lack of adequate scrutiny.Emerging post-quantum candidates can be naturally embedded into rich and modern mathematical theories. It is the case of lattice-based and isogeny-based cryptography, which share surprising connections once recast in the world of algebraic groups. Algebraic groups are at the forefront of modern mathematics. Their study across the past century has blossomed with the development of powerful theories, such as representation theory and automorphic forms. Yet, the dialogue between arithmeticians and cryptologists has been sparse, and the link between algebraic groups and the objects of post-quantum cryptography has been mostly anecdotal.This project brings this connection to the forefront, observing that the theory of algebraic groups shines a powerful light on problems raised by lattice-based and isogeny-based cryptography. It has the unique ability to turn the set of all instances of a computational problem into one meaningful object in itself — a 'moduli space' — with an arithmetic structure, a geometry, a topology, a harmonic theory. Exposing these problems to the powerful artillery of modern arithmetic will lead to cryptanalytic breakthroughs, security proofs, and the construction of cutting-edge cryptosys