RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanoparticles-reinforced materials: novel design concepts and methods of tailoring for vibration damping' (2002-2006) under Sixth Framework.

assistant: **Objectives**

A novel concept of nano-particle vibration damping shows the effect that molecule-level mechanism can have on the damping and that nano-particles/fibres/tubes-reinforced materials can provide enhanced strength and vibration damping properties. It is particularly worth noting that carbon nano-tubes and spider silk can act as a simple nano-scale spring. The mechanisms involved in such materials need to be understood and the relevance to damping identified. Manufacturing design concepts and modelling techniques fo r the next generation of vibration damping systems are technology gaps that need urgent consideration. The focus in this project is directed toward to the investigation into carbon-based nano-particle-reinforced materials and coating systems and their dynamic/damping characterization. Computational work to be formulated in terms of meso- and nano-scopic ideas of damping behavior will be concentrated on multi-scale modelling of damping behaviour as a function of frequency, amplitude and temperature. A particular aim of the project is the tailoring of structural nanoparticle-reinforced materials for vibration damping. Simultaneous optimization of damping, stiffness, weight and cost of a class of nanoparticle-reinforced materials can be carried out. By establishing a strong linkage between the multidisciplinary sciences (material sciences, chemistry and mechanics), the proposed research will address both theoretical and applied aspects. The project will create a platform for the development of damping materials and manufacturing design concepts for the future generation of damping materials. The outcome of the project is expected to have wide-ranging technical benefits with direct relevance to industry in areas of transportation (aerospace, automotive, rail) and civ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synergistic Nano-Therapeutic Approach for Psoriasis: Targeting TNF-α and IL-17 Pathways via Transdermal Delivery' (SKINNOVATE).

assistant: **Innovation**

Psoriasis, affecting 2-3% of the global population and 20 million individuals in Europe, poses significant challenges in treatment efficacy and patient adherence to current therapies. Addressing these challenges, this project proposes an innovative therapeutic strategy by integrating Etanercept (ETR), a TNF- inhibitor, with small interfering RNA (siRNA) targeting IL-17A, facilitated through a novel transdermal delivery method. The project aims to develop and optimize hybrid lipid-polymer nanoparticles (LPNs) for co-delivering ETR and siRNA. These LPNs will be incorporated into microneedles (MNs) composed of biocompatible polymers, pectin, and polycaprolactone (PCL). This dual delivery approach leverages LPNs' controlled release properties and MNs' enhanced skin permeability to target multiple pathogenic pathways involved in psoriasis synergistically. Specific objectives include optimizing LPN formulation, evaluating efficacy in vitro, characterizing the MN system for skin penetration, and assessing performance in ex vivo psoriasis models, guided by ethical principles (3Rs: Replacement, Reduction, and Refinement). Expected outcomes encompass improved treatment efficacy, reduced adverse effects, and enhanced patient adherence, thereby advancing psoriasis management. Furthermore, this project seeks to catalyze interdisciplinary collaborations and propel the development of novel therapeutic strategies, contributing to scientific innovation and healthcare advancement.


**Keywords:** Biomedical Engineering,  Drug Delivery,  Nanotechnology,  siRNA,  Lipid-Polymer Nanoparticles,  Microneedles,  Transdermal Delivery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular mechanism of protection by antibodies against the dengue virus and their engineering for therapy' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The applicant is a female, assimilated Polish scientist, who has worked in the fields of transgenic plants and edible vaccines. She wants to complete her training at the Pasteur Institute in Paris, in the fields of protein and antibody engineering. The combination of both competences will have an enormous potential in health.Dengue is a re-emerging disease, which is viral, vector-borne, poverty-linked and affects 100 million persons each year. No vaccine or specific treatment is available. The dengue virus has 4 serotypes, DEN1 to DEN4. Monoclonal antibody mAb4E11 is directed against the DEN1 virus. It binds to domain 3 of the viral envelope protein E, neutralizes the viruses of the 4 serotypes, and protects the mouse.The project consist in:- understanding the molecular mechanisms by which mAb4E11 interacts with the dengue virus and neutralizes its 4 serotypes; and - using this knowledge to develop derivatives of mAb4E11 that could be used in passive immunotherapy.The project could also lead to improved vaccines or diagnostics. Put briefly, Domain 3 (rE3) of protein E will be expressed in a recombinant form. Assays will be set up to quantify the interactions between rE3 and:- mAb4E11;- the proteinous receptors of the virus on target cells; and- the heparan sulfate co-receptors.Known mutations that affect virulence, will be introduced into rE3 by mutagenesis and their effects on these interactions measured. The binding site for mAb4E11 and for the viral (co-)receptors will be identified at the surface of rE3 by mutagenesis and compared. The relations between the molecular structure of mAb4E11 and the neutralization (or enhancement) of the viral infection will be analyzed by constructing recombinant derivatives of this antibody.The structures of rE3 and mAb4E11 will be de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'An anthropological study of truth wars from marginalized standpoints'.

assistant: **Objectives**

In today’s age of post-normal science and fragmentation of the public sphere, truth itself has become an increasingly contentious and contested concept. De-CRIPT will introduce theoretical andmethodological innovations into research on truth-making processes to expand current understandings of the nexus between controversial truth claims (particularly those labelled conspiracy narratives) and socioeconomic disadvantage. Comparing four paradigmatic communities subject to longstanding or newly-emerging processesof downwards social mobility across four different countries of Western Europe, the project seeks to understand:- the conflicts between mainstream and conspiracist discourses in the online sphere and in everyday offline interactions;- the conditions that make controversial truth claims acceptable or appealing among disadvantaged groups;- connections and disconnections between the communicative intentions of the main creators and propagators of controversial truth claims online, on the one side, and the pragmatic uses of the same claims by ordinary social actors in everyday life, on the other.Theoretically, De-CRIPT will introduce into research on truth-making processes: 1) the philosophical tradition of pragmatism (with its linguistic and sociological legacies) in order to focus on social actors’pragmatic uses of truth claims to justify their practices and/or produce specific effects, and 2) a feminist epistemological lens, which examines processes of knowledge production and circulation by payingattention to different forms of oppression, in order to expand current understandings of the conditions of acceptability of controversial truth claims among low-status groups. Methodologically, it will encompass both conspiracy narratives and the narratives opposing them,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solar-thermally driven desalination system with corrosion free collectors and 24-hours-per-day storage' in the context of a Fourth Framework call.

assistant: **Objectives**

OBJECTIVES OF THE PROJECT 1. To design, set up, operate, evaluate and finally assess a solar thermally driven distillation system that works at 80 C. In the project a pilot system will be operated that has a capacity of 30 litres per hour. The system will be driven by thermal solar energy. 2. To develop, design, construct and operate corrosion-free solar collectors that are suitable and appropriate for the distillation system. 3. To develop and optimize a strategy for operating the solar driven systems for 24 hours-per-day by including a thermal heat storage into the system. The aim is to increase the daily distilled water production from about 150 (without storage) to 600 litres per day. 4. To gather operation experiences and to fully assess the performance and cost results (ECU/m3 potable water) of this system. Additionally, a study will be elaborated to estimate application potentials and water production costs for the case that the distillation unit is driven by diesel waste heat instead of solar collectors. Finally the aim is to evaluate the possibilities for; the application and dissemination a these systems, especially in the Mediterranean countries. TECHNICAL APPROACH The general technical approach to achieve the project goals is based on experimental investigations and developments. The necessary different tasks of the project will be conducted by partners that are specialists in their field of work. This concerns the development of the collector (ISE), the development of the operation strategy (ZAE), the installation and monitoring of the pilot system (CIEA and OS) and the investigations on the water treatment USE). The full technical and economic assessment of the complete desalination system with special concern of the Mediterranean application potential wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cost-effective CO2 conversion into chemicals via combination of Capture, ELectrochemical and BI-ochemical CONversion technologies' (CELBICON), addressing dissemination and exploitation.

assistant: **Impact**

CELBICON aims at the development, from TRL3 to TRL5, of new CO2-to-chemicals technologies, conjugating at once small-scale for an effective decentralized market penetration, high efficiency/yield, low cost, robustness, moderate operating temperatures and low maintenance costs.In line with the reference Topic text, these technologies will bridge cost-effective CO2 capture and purification from the atmosphere through sorbents (with efficient heat integration of the CO2 desorption step with the subsequent process stages), with electrochemical conversion of CO2 (via PEM electrolysis concepts, promoting CO2 reduction at their cathode in combination with a fruitful oxidation carried out simultaneously at the anode), followed by bioreactors carrying out the fermentation of the CO2-reduction intermediates (syngas, C1 water-soluble molecules) to form valuable products (bioplastics like Poly-Hydroxy-Alkanoates - PHA -, isoprene, lactic acid, methane, etc.) as well as effective routes for their recovery from the process outlet streams.A distinctive feature of the CELBICON approach is the innovative interplay and advances of key technologies brought in by partners (high-tech SMEs & companies, research centres) to achieve unprecedented yield and efficiency results along the following two processing lines: i) High pressure process line tailored to the production of a PHA bioplastic and pressurized methane via intermediate electrochemical generation of pressurized syngas followed by specific fermentation steps; ii) Low pressure processing line focused on the production of value-added chemicals by fermentation of CO2-reduction water-soluble C1 intermediates.Over a 42 months project duration, the two process lines described will undergo a thorough component development R&D programme so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EUROPRACTICE CAD and IC Service for European universities and research institutes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project is to continue the current EUROPRACTICE IC4 Service.<br/>The current EUROPRACTICE IC4 Service project, part of the 7th Framework and ending on 31 December 2010, is widely recognized as a world-leading service offering state-of-the-art CAD tools and microelectronics-based technologies to universities and industry.  Today, through the EC funding of the EUROPRACTICE IC4 project, 650 European Academia (550 universities and 100 research centers) have access to this Service.  Continuation of this project is considered indispensable as universities need to be able to renew their annual CAD licenses for continuing support of their research and training courses and need to get further IC prototyping services.  In order to avoid a gap (waiting for the next call – possibly in 2011), this proposal is submitted now.  As the budget for CSA activities in Call 5 is limited, the proposal covers only 1 year of full operation (2011).<br/>The objectives are offering access to CAD tools for training and research, and access to advanced IC and MEMS technologies for prototyping.<br/>As a broker, EUROPRACTICE negotiates low cost conditions with the most popular industry-standard CAD vendors for educational use and non-commercial research within the 650 European Academia.  EUROPRACTICE has negotiated with several IC and MEMS foundries agreements to buy or share low cost MPW (Multi Project Wafer) runs in order to offer low cost prototype possibilities to universities and research institutes.  New advanced technologies, such as 65nm and 40nm CMOS will be added to the portfolio of technologies as soon as those technologies become available and affordable.<br/>Also discussions are going on with other European service" providers, initiated by EC funded projects, in order to make them av
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamics and Cooperative Phenomena in Complex Physical and Biological Media' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of the DCP-PhysBio exchange program is to bring together several European teams (France, Germany, UK), Israel, as well as partners from Russia and Ukraine. We want to use our combined expertise to study various challenging dynamical and cooperative phenomena taking place in complex physical and biological systems. All the teams have a track record of research in these areas concentrating on particular numerical or theoretical facets, such that the network will synergistically amplify their strengths. The staff exchanges will include both a team research work on specific work packages which will further consolidate the research partnership, and a transfer of knowledge component of workshops, schools and seminars which will ensure an effective dissemination of results and foster interactions amongst the young researchers. If the aims of our proposal are to be achieved, then not only that a long-term research network will emerge but a number of PhD students and early career researchers will have had been mentored into, and intensively exposed to, a culture of international collaborative research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ENLARGE – ENergies for Local Administrations: Renovate Governance in Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Co-design and co-production processes are promising horizontal governance tools to innovate public administrations and the public sector in general. In particular, co-design processes aim at improving policy effectiveness by including a wide range of viewpoints in the formulation of public policies and in the design of public services, while co-production processes are designed and managed to involve ‘responsible citizens-users’ in the implementation of the policies and in public service delivery, and aim not only at improving policy effectiveness, but also at sustaining public sector intervention in the recent austerity era, during which governments (especially local governments) must face new social needs and complex problems with decreasing public resources.Notwithstanding the high potential of these processes as innovative and effective governance tools, practical evidence about their usefulness and sustainability for local administrators is still lacking, and local governments proceed mostly incrementally and unaware of potentials and pitfalls. ENLARGE project aims to shed some light on the ‘how and why’ issues of co-design and co-production processes through an intense policy dialogue between policy makers, experts in participatory governance and civil society actors. The specific focus is on sustainable energy and more in general all the solutions aiming at generating more efficiency and effectiveness in public services and public endowments. In detail, the project intends to: EXPLORE the existing models of co-design and co-production of public policies and services; EVALUATE – measures for the assessment of the outcomes; mechanisms and intervening factors favouring the effectiveness of participatory processes; PRODUCE - Raising awareness among public administrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Targeting NLRP3-mediated inflammation with novel chemotypes'.

assistant: **Innovation**

Inflammasomes play a vital role in in protecting humans against pathogenic microorganisms, harmful substances and cell changes that could result in illness. The NLRP3 inflammasome in particular attracts considerable interest because aberrant NLRP3 activation is a key pathogenic mechanism in many chronic inflammatory diseases. Moreover, gain-of-function mutations in NLRP3 causes a periodic fever syndrome named cryopyrin-associated periodic syndrome (CAPS). MCC950/CRID3-based sulfonylurea compounds are currently the only reported class of inhibitors that selectively target NLRP3 with nM potency. We and others recently showed that members of this sulfonylurea class inhibitors directly target the central NACHT domain of NLRP3, and several companies have recently progressed MCC950/CRID3-derived NLRP3 inhibitors to human studies. However, there is an urgent need to expand the pipeline of NLRP3-targeted therapeutics with NLRP3-inhibitors of novel chemotypes. Based on exciting preliminary data, we aim to identify novel NLRP3 inflammasome inhibitors and perform an in-depth functional analysis of their activity, selectivity and molecular mechanism of action. Furthermore, we will define the market potential and explore the best strategy towards clinical development with partner organizations. In conclusion, the project will help to expand the pipeline of NLRP3-targeted therapeutics with new NLRP3-inhibitors. If successful, the project may meaningfully impact on the lives of many patients that suffer from NLRP3-mediated diseases in Europe and across the globe.