RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Comprehensive Platform for the Functional Characterization of Cancer Epigenetics and Diagnosis' (EpiCancer).

assistant: **Concept**

Epigenetic regulation of gene expression- the mechanism responsible for establishing and maintaining cellular identities during development- is frequently deregulated in cancer. Our working hypothesis is that this deregulation confers upon cells phenotypic plasticity, resulting in intratumor heterogeneity, which is key to tumor development, metastasis, and drug resistance. In EpiCancer, we seek to provide the technological means to address fundamental issues concerning epigenetics in cancer. Namely, we intend to develop, apply, and validate single-cell and single-molecule epigenetic analysis methods that can parse the function of this network and its heterogeneity in human cancer, and utilize it for cancer diagnosis. We will build a rich arsenal of tools to profile the combinatorial epigenetic network in primary tumors and blood taken from cancer patients at multiple scales of resolution (Aims 1 + 2). We will apply these systems to elucidate the function and connectivity between epigenetic modifications in breast cancer and lymphoma, and link epigenetic heterogeneity to tumor biology and clinical outcome (Aim 3). We will also establish revolutionary systems for cancer diagnostics and monitoring, leveraging the unique advantages of our single-molecule tools for multi-modal analysis of epigenetic, protein biomarkers, and microRNAs, originating from both the tumor and its microenvironment, in patients’ blood (Aims 1 + 3).The epigenetic technologies we intend to provide the scientific community are set to profoundly impact our understanding of the epigenetic determinants of cancer, as well as our ability to detect cancer at early stage from a routine blood test and identify early disease recurrence. The analysis of a large cohort of tumor and blood samples from the same pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deciphering the COMPASS that guides cancer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Epigenetic features are commonly dysregulated in cancer and one of the surprising findings from the sequencing of cancer genomes is the high rate of alterations in many epigenetic regulators. KMT2D/MLL4, KMT2C/MLL3 and KDM6A/UTX are among the most frequently mutated genes in a wide range of cancers and in normal aged epithelial cells. Interestingly, these three genes are components of the same complex, COMPASS-like complex that regulate enhancer activity and regulate gene expression in a lineage specific manner. The deletion of members of the COMPASS-like complex has been associated with altered differentiation, aging and tumorigenesis. However, the precise mechanisms by which mutations in these genes impact cell states during tissue homeostasis, tumour initiation, tumour heterogeneity and metastasis, remain poorly understood. To address these important questions, we will use multidisciplinary approaches that will combine in vivo single cell lineage tracing, single-cell genomics, epigenomics and transcriptomics, in vivo CRISPR-based gene editing, together with genetic and pharmacologic perturbations, to define in a comprehensive and integrated manner the impact of Kmt2d, Kmt2c and Kdm6a deletion on cell state dynamics during homeostasis, regeneration, early steps of tumour initiation, tumour heterogeneity and metastasis in skin squamous cell carcinoma and bladder cancer. Moreover, we will perform genome wide CRISPR-Cas9 screen to identify the synthetically lethal genes in KMT2D, KMT2C and KDM6A mutated cancer cells to uncover new tumour vulnerabilities that can be pharmacologically targeted.


**Keywords:** Stem cell dynamics, epigenetic regulation, histone methyl-transferases, COMPASS-like complex, clonal evolution, tissue regeneration, tumour initiation, tumour hetero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Research Area for Climate Services' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Within the European Research Area (ERA), the ERA4CS Consortium is aiming to boost, research for Climate Services (CS), including climate adaptation, mitigation and disaster risk management, allowing regions, cities and key economic sectors to develop opportunities and strengthen Europe’s leadership. CS are seen by this consortium as driven by user demands to provide knowledge to face impacts of climate variability and change, as well as guidance both to researchers and decision‐makers in policy and business. ERA4CS will focus on the development of a “climate information translation” layer bridging “user communities” and “climate system sciences”. It implies the development of tools, methods, standards and quality control for reliable, qualified and tailored information required by the various field actors for smart decisions.ERA4CS will boost the JPI Climate initiative by mobilizing more countries, within EU Member States and Associated Countries, by involving both the research performing organizations (RPOs) and the research funding organizations (RFOs), the distinct national climate services and the various disciplines of academia, including Social Sciences and Humanities. ERA4CS will launch a joint transnational co-funded call, with over 16 countries and up to 75M€, with two complementary topics: (i) a “cash” topic, supported by 12 RFOs, on co-development for user needs and action-oriented projects; (ii) an “in-kind” topic, supported by 28 RPOs, on institutional integration of the research components of national CS. Finally, ERA4CS additional activities will initiate a strong partnership between JPI Climate and others key European and international initiatives (as Copernicus, KIC-Climate, JPIs, WMO/GFCS, Future Earth, Belmont Forum…) in order to work towards a common
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fostering Outermost regions Capabilities in Research and Innovation and Upgrading Skills complying with 4R principles' under Horizon Europe.

assistant: **Concept**

The EU outermost regions (ORs) face unique challenges and opportunities in the biomedical sector due to their geographical remoteness, insularity, and specific socio-economic conditions. Despite significant R&I initiatives in the past years, which hold great potential to address the health challenges faced by these ORs, the creation of new businesses and jobs remains low. In addition, the lack of specialized biomedical researchers and innovators hampers the ability of ORs to conduct cutting-edge research. FOCUS-4R aims to enhance the R&I capacities of the ORs, helping them to gain autonomy, competitiveness, and attractiveness in the biomedical field. The FOCUS-4R project brings together 3 emblematic ORs (Reunion Island, Canary Islands and Madeira) to leverage the expertise they have developed over recent years to create growth opportunities and increase the excellence of their institutions.  Bringing together an intersectoral and interdisciplinary network of 6 academic institutions and 5 non-academic partners from 4 Widening regions and 4 Advanced countries, the project will offer cross-sectoral training and talent mobility through secondments and workshops. FOCUS-4R aims to develop a relevant path to assess therapeutic effects of molecules rapidly and at a low cost without ignoring the ethical issues by focusing on identified techniques that meet the principles of 4R (Replacement, Reduction, Refinement and Responsibility). Through training and mentoring from advanced partners, FOCUS-4R will develop transferable skills essential to meet the industrial and market needs and enhance entrepreneurship in the ORs. By providing training, lifelong learning opportunities and by consolidating knowledge transfer, FOCUS-4R will contribute to bridge the gap between ORs and advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rethinking climate change vulnerability:  Drivers  patterns of thermal tolerance  adaptation in the ocean.' (DPaTh-To-Adapt), addressing dissemination and exploitation.

assistant: **Impact**

Climate change is having pervasive impacts on biota that is collectively resulting in a fundamental alteration of the structure, function and feedbacks within ecosystems across the globe. A major challenge for climate change science is to develop an understanding of the sensitivity of organisms to the changing environment, and try and find spatial, broad taxonomic or trait based generalities that will enable more accurate identification of regions and ecosystems at severe risk of climate change impacts (sensitivity hotspots) so that mitigation and adaptive management actions can be prioritised. There are, however, several challenges associated with predicting sensitivity hotspots. At the forefront of these challenges is our understanding of the drivers of organism’s thermal tolerance thresholds, and the proximity of temperature thresholds to the local climate extremes and climate change projections, herein called thermal safety margin (TSM). This project merges concepts from physiology, ecology, evolutionary biology, biogeography and physical oceanography into an interdisciplinary conceptual framework that exposes inconsistencies among current paradigms and fundamental limitations to our understanding of the sensitivity of marine organisms to climate change. The conceptual framework presented here offers a testable, interdisciplinary model to address this knowledge gap. Specifically we ask the questions 1) How do patterns in thermal tolerance breadth and thermal safety margins vary throughout species’ geographical ranges? And 2) What are the environmental drivers, biotic traits and evolutionary factors that determine an organisms thermal tolerance? Through identifying the nature of thermal tolerance patterns and identifying some of the mechanisms influencing these patte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A HUMANITARIAN DRONE FOR THE RAPID DETECTION OF LANDMINES AND OTHER EXPLOSIVE REMNANTS OF WAR' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Today there are 110M landmines in the ground in 78 countries including in Europe, killing between 15,000 -20,000 a year. The removal of landmines is slow (deminers using metal detectors must clear heavily mined sections manually), dangerous (for every 5000 mines cleared 1 worker is killed and 2 injured), and costly ($300–1000 to remove 1 mine). Currently there is no way to rapidly detect landmines over a large area of land. Deminers must go meter by meter and manually detect and then remove the mines. This takes huge amounts of time and means having to cover areas that do not have mines. In the past 5 years less than 1000 km2 worldwide were cleared of mines. If demining continue at the current pace it will take 1100yrs to remove all the landmines. To meet the need for a fast way to detect landmines we created the Anti-Landmine Drone (ALDrone) a small, lightweight drone that detects landmines using a multispectral camera to spot the erosion created by the decomposition of the chemical elements in a mine. The advantages of an aerial detection system are higher speeds, our system can cover the same area in 1 day that other landmine detection methods take a month to cover, and an off-site central control station meaning no chance of explosion while locating mines. Our solution is also competitively prices to make it available to as many people as possible. Thanks to the Mine Ban Treaty countries worldwide have committed to eliminating all the mines in the world. In 2013 the EU contributed over 2M€ to demining activities, international support amounted to almost $435M and national support almost $198M. While are target market is clearly a niche market our total addressable market is significant. And while the demand for a product like ALDrone is very specific we already have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DNA rEpair impaired Mice with accElerated Neurodegeneration as Tool to Improve Alzheimer therapeutics' (Dementia), addressing dissemination and exploitation.

assistant: **Impact**

Alzheimer’s disease (AD) affects worldwide ~50 million people. Preclinical research relies mainly on transgenic mouse models overexpressing mutant human proteins that are altered in <5% of AD cases (e.g. β-amyloid and tau), however, despite prominent protein aggregates, they fail to show the dramatic neurodegeneration and cognitive decline of patients, indicating that plaques and tangles may not be the only requirement for AD. Age is the most determining factor in AD, but is poorly represented in current AD models.Generating bona fide mouse models for various human DNA repair syndromes we have disclosed a very strong connection between DNA damage, repair and aging including dramatic neurodegeneration. Within the context of ERC-DamAge we discovered striking parallels in neurodegeneration, progressive cognitive decline and genome-wide expression profiles of repair-deficient Ercc1Δ/- mice and human AD. The similarities in expression profiles are an order of magnitude higher than current AD mouse models. We discovered that nutritional interventions can spectacularly delay neurodegeneration, opening realistic perspectives for combating AD and other neurodegenerative disorders. The primary goal of this application is to complete the characterization of the mouse mutants as a valid model for AD by a detailed quantitative comparison of all RNA classes of relevant brain compartments of Ercc1Δ/- mutants and AD patients. This not only provides the final PoC, but also an unparalleled resource for pathway analysis, target identification and biomarkers for monitoring disease progression and effects of any intervention. This application will be instrumental to facilitate transition to a valid AD model for pharmaceutical companies enabling development of effective medication for preven
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTIFREQUENCY IMPEDANCE MEASUREMENTS TECHNOLOGY FOR MEAT QUALITY CONTROL' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Multifrequency Impedance Measurement (MIM) technology was tested by NTE (ES), an aerospace engineering company, and IRTA (ES), a meat research institute, during the last few years to assess meat quality in different types of meat with satisfactory results. The technology was evaluated for PSE pork determination and General meat quality determination. The results of every application were two reliable MIM systems. The logical continuation of this work was the supply of the technology to the meat processing industry, as well as the technology assimilation.This project represented the required continuation of the activities. In order to perform a validation of the technology for industrial application, several companies were invited to carry out activities together with IRTA and NTE in the project MIM-Q of the INNOVATION program: two meat processing companies ESPUÑA (a Spanish SME), IMPERIAL (BE) and a meat processing hardware manufacturer KARL SCHNELL (a German SME). The main objective of the project was the validation of the technology to serve as a reliable tool for meat quality determination.In order to obtain such a reliable tool, the two developed systems were tested for the above mentioned applications under industrial conditions. Three of the partners tested the systems at their facilities and during their standard industrial processes. These three partners then played the role of the end users for the two applications. ESPUÑA evaluated the General Meat quality application. Its interest in this part is to use a reliable tool to improve its ham curing production process. IMPERIAL evaluated the PSE pork determination, which is based on improving its production of high quality cooked ham. KARL SCHNELL evaluated one aspect of the General Meat Quality, which is the Fat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AlGaN and InAlN based microwave components' (AL-IN-WON), addressing dissemination and exploitation.

assistant: **Impact**

This proposal is focused on the development of a new generation of wide band gap (WBG) GaN technology and devices for which strong impacts in term of performances, reliability and robustness are expected.AL-IN-WON  will explore two main disrupting routes:-Next generation of WBG device based on new epi material (InAlN/GaN) for strong improvement in term of performances and reliability.-High efficiency / High Power generation in Ku / Ka bandsIt proposes to evaluate in 2 phases next generation of WBG material up to Ka Band.The InAlN/GaN heterostructure offers the following advantages:As InAlN/GaN is lattice matched, it offer the possibility to growth very thin layer in the range of 10nm or below WHICH IS THE MOST RELEVANT to overcome short channel effect AND GO TOWARDS HIGH frequency range up to millimeter wave range.In0.18 Al0.82N /GaN is a new heterostructure able to give twice the drain current available from a more conventional AlGaN/GaN heterostructure.  Breakdown voltage is comparable for the two heterostructures.In0.18 Al0.82N is latticed matched to GaN and higher reliability is therefore expected compared to AlGaN/GaN.Passivation is currently a major limitation to device operation. InAlN/GaN MOSHEMT are very promising with strong current drain improvement compared to HEMT (UltraGaN).We plan to evaluate CW Ku and Ka Band MMIC High Power Amplifiers (HPA) and Low Noise Amplifiers (LNA). Demonstrators in Ka band will be designed based on devices coming from the run 2.The final objective being the evaluation of InAlN/GaN compared to more conventional AlGaN/GaN very high power HEMT technology with very high breakdown voltage, high current and compliant with high power density. Regarding space application for which reliability and robustness are of major concerns, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Training Wind Energy Experts on Digitalisation' (TWEED) under Horizon Europe.

assistant: **Objectives**

Training Wind Energy Experts on Digitalisation (TWEED) Doctoral Network (DN) aims to train the next generation of excellent researchers equipped with a full set of technical and complementary skills to develop high-impact careers in wind energy digitalization. This goal will be achieved through an outstanding research-for-innovation programme, and a unique training programme that combines hands-on research training, interactive schools and hackathons, innovation management and placements with non-academic partner organizations An integrated research program will be carried out alongside the development of a Virtual Wind Energy Data Science Hub that facilitates a virtual research environment to foster collaboration, data sharing and testing of innovative solutions seeking drastic cost-of-energy reductions. The network will provide an interdisciplinary and inter-sectoral context to foster creativity in transforming technological challenges into data science problems that can be solved to develop prototypes for commercial exploitation. Researchers will be trained in business innovation to extend their focus beyond the academic context to be able to identify added-value products or services through customer discovery and guidance from established researchers and entrepreneurs. As a result, a research-for-innovation mindset will be developed to provide enhanced career perspectives to the fellows, equipped with a complete set of thematic, technological and innovation skills. Moreover, TWEED network will accomplish the foundation of Wind Energy Data Science (WEDS) as a new research discipline across the EAWE network to raise awareness, exploit synergies, and motivate future career choices. The potential of data-intensive science as a new paradigm will allow reducing the cost o