RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Highly performing small diameter polyurethane vascular grafts'.

assistant: **Innovation**

There is an urgent need to design and fabricate reliable small-diameter vessel grafts (SDVC) which could be taken from the shelf and used with a good degree of acceptability in any low diameter vessel replacement. This is related to the scarce availability of autologous prostheses (saphenous vein and mammary artery), the generally unsatisfactory condition of such material, and to the absence on the market of reliable small-diameter synthetics. The principal use of these grafts is in the peripheral districts e.g.: below the knee, and at the cardiac level, e.g.: coronary artery bypass.The overall objective of the HYPER-GRAFT project is to produce less than 6 mm internal diameter artificial vessels to replace autologous blood vessels in humans. The specific project objectives are to prove with animal implantation experiments that these artificial prototypes are at least comparable with autologous vessels.The main thrust of the HYPER-GRAFT project is to investigate fundamental issues related to the design and fabrication of a new generation of highly performing polyurethane SDVG capable of elastically withstanding blood pressure, to be selfsealing, to remain patent in a low flow configuration, and not to induce neointimal hyperplasia in the anastomotic regions. The grafts must promote a minimal tissue connective growth on the luminal surface and support the formation of a thin and stable neointima", and last but not least to be "biostable" in long term implantation situations.The HYPER-GRAFT project is based upon a number of key features. First, a new innovative technology, patented by Kontron Instruments (KONTRON Milano, Italy) and further developed by the Istituto di Fisiologia Clinica CNR (IFC-CNR Pisa, Italy), will be adapted to the fabrication of small-diameter vessel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Renal macrophages as natural biosensors and therapeutic targets' (MACRORIEN) under Sixth Framework.

assistant: **Objectives**

This proposal is designed to add value to the European science community by enhancing the research and training required to improve treatment for chronic kidney disease that is a major threat to health in Europe. If successful, it will enable Professor Rees, an internationally recognised renal immunologist from the UK to translocate to the Institute of Clinical Pathology at the Medical University of Vienna where he would establish a joint teaching and research program with Professor Kerjaschki, the outstanding renal pathologist and cell biologist who heads the Institute. The resulting partnership would exploit their complementary expertise to make the Institute into a world-class European centre for much needed renal research and research training. First, the proposal will enable Professor Rees to develop a research program in the Institute designed to characterise macrophages infiltrating the damaged kidney and exploit their ability to either cause injury or to promote tissue repair depending on how they are activated.This will be used both, to develop macrophages as endogenous biosensors" of disease activity in the kidney and to identify novel therapeutic targets. Second, he will organise an outstanding research training program that combines specific training in renal research with generic skills to facilitate researcher mobility throughout Europe. Finally, he will establish a series of international "Frontiers of Renal Immunology" meetings that will enhance research in this area.  The proposal will promote the wider aims of the Marie Curie action and should benefit European science by developing a new multidisciplinary research centre in a much needed area."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Next generation advanced RNA inhibition therapy to treat cardiometabolic disease' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

RNA Therapeutics comprise a new rapidly expanding category of drugs including small interfering RNAs (siRNA) and messenger RNAs (mRNA) that have attracted tremendous interest recently due to their first in-class drug approvals and notable success of the mRNA vaccines in the clinic.Obesity, diabetes, non-alcoholic fatty liver disease (NAFLD) and atherosclerotic cardiovascular disease (ASCVD), in turn, are highly prevalent devastating diseases of our times despite available medicines, accounting for more than one in two deaths worldwide. They frequently co-exist, in the same patient, and constitute independent risk factors for each other; yet, unified approaches directed against common targets and shared mechanisms are lacking.LiverTarget aims at exploiting Partners years of research in the field of cardiometabolic research, the identification of ceramide pathways and inflammatory targets, and the development of novel siRNA technologies and lipid formulations, to: 1.Generate innovative siRNA pools and synthetic mRNAs to regulate ceramide and inflammatory targets in the liver. 2.Formulate them in established human-approved liver-targeting lipid nanoparticles (LNP). 3.Determine their efficacy in vivo in preclinical mouse models of obesity, diabetes, non-alcoholic fatty liver disease (NAFLD) and atherosclerosis.4.Complete the necessary safety and toxicology evaluation of the most promising lead candidates and prepare the preclinical evaluation dossier for the European Medicines Agency (EMA). This will result in a set of novel RNA-LNP formulations, directed against targets shared between ASCVD, diabetes and NAFLD, with demonstrated efficacy and toxicology, ready for further clinical development. It will also open up new directions of research towards the development innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Introducing a novel concept of solar photovoltaic module in the market' (SoHo3X).

assistant: **Innovation**

For more than 40 years, solar photovoltaic modules have not changed. The idea of interconnected cells sandwiched between glass and back sheet is still the same, and basically only the cell efficiency has increased. Given that cost reduction is a market driver in the photovoltaic business, it is necessary to pursue all fields leading to cost reduction and efficiency increase, including also module design. As a substitute for crystalline silicon flat modules, a new design of a trackless 3D concentrated photovoltaic (CPV) module has been designed and prototypes built. Its key characteristic is the use of holograms as optic concentrating devices in combination with other optical elements to obtain high optical efficiency achieving a concentration factor of 3X without tracking. Prototypes have been measured under industry relevant conditions. Results show the enormous potential of the design: up to 91% more annual performance ratio than conventional flat silicon fixed modules. Mass manufacturing costs of such modules have been estimated below EUR 0.40 per watt peak, i.e., even below silicon flat module. Given all these premises and the potential this product has in the growth and internationalization of the company, a business plan to launch this novel PV module product to the market is proposed in the present project. The business plan will cover all aspects for the company to enter the photovoltaic market with this product, among others: the analysis of technical risks and technical steps towards commercialization, including automated production lines, market survey of possible competitors, potential customers and markets segments, etc. The report must analyze all these issues and propose answers to how to approach them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The origin of planetary systems' (PLANETS), addressing dissemination and exploitation.

assistant: **Impact**

Young European researchers will collaborate with leading European research groups in this timely field. In order to encourage interaction and promote training in observational and theoretical astronomy a strong visiting program among the cooperating institutions will be organized. For graduate students and postdocs advanced schools will be offered on the subject of the network, observational and numerical techniques, search strategies and proposal preparation. The young researchers will have access to unique observational facilities and instruments. They will get rigorous training in laboratory physics and computational physics using special hardware computation and on data reduction with special focus on the data from the Space Infrared Telescope Facility. Their acquired technical skills and the management experience, gained by participating actively in the coordination of research projects are highly demanded in industry and modern economics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Myeloid  Cells: Investigating their Role for Immunotherapy in Cancer', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

With more than 3.7 million new cases and 1.9 million deaths each year, cancer represents the second most important cause of death and morbidity in Europe with the estimated direct health cost increasing from €79 to €86 billion during 2005-2014. The emerging field of immune-checkpoint therapy (ICT) has demonstrated unprecedented responses in patients with several types of metastatic tumors that were previously resistant to available treatment options. However only ~13% of patients respond to the immunotherapy. I believe the primary reason for this is that most therapies are T cell directed and to achieve durable responses one must also engage the innate arm of the immune system. Myeloid cells constitute a major proportion of tumor infiltrating cells in human cancers and are essential for the induction of antigen specific T cell responses-cells which mediate anti-tumor immunity.  Tim-3 is a check-point molecule that is not only expressed on T cells but also constitutively expressed on Dendritic cells, namely DC1, which are particularly adept at initiating protective anti-tumour immunity. A number of studies have highlighted the crucial role of DCs including analyses of The Cancer Genome Atlas showing that patient survival for many cancers correlates positively with the gene expression signature for DCs. Given the current activity in developing Tim-3 blocking agents for clinical translation, it is imperative that we have a full understanding of how modulation of Tim-3 affects the innate arm of the immune system.   The aim of this proposal is to determine the cell-intrinsic and non cell-intrinsic effects of Tim-3 modulation in cancer.  Furthermore we will analyze the cellular and transcriptional changes associated with tumour infiltrating DC after ICT with anti-Tim3. This p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing lightweight modules for transport systems featuring efficient production and lifecycle benefits at structural and functional integrity using risk based design' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Complex lightweight modules for ships and railway will be developed using risk based design methods. The modules will contain structural and outfitting components. The modules can be efficiently pre-assembled under favourable working conditions using economy of scale. Modules can be adapted to customer needs thus featuring structural and functional integrity, improved safety and environmentally friendliness as well as efficient operation and reduced life cycle cost.  The development of lightweight modules will thus contribute to increase the competitiveness of European producers and operators of transport systems. The application of risk based design methods will allow to develop highly innovative solutions exceeding the range of existing classification rules by exploring new material combinations, innovative joining, assembly and pre-outfitting techniques. The scope of applications followed by DE-LIGHT reaches from passenger and RoRo ships, through cargo and short sea ships, to inter-modal transport units and railway carriages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stabilis – Providing relief for tremor patients' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Millions of people worldwide have trouble with involuntary shaking hands. These shakes are called tremors, commonly seen in Parkinson’s Disease, Multiple Sclerosis, and Essential Tremor. Tremors lead to a lot of frustration. Not only does it make eating and drinking difficult, or impossible,  but people are often ashamed.  Current treatments to suppress tremors are often inefficient and lead to heavy side effects. There is a need for a new solution. STIL is developing a medical device that will enable people with tremors to return to their activities of daily living. The STIL anti-tremor orthosis (called Stabilis) uses technology that suppresses the tremor but still allows voluntary movement. With its lightweight and ergonomic design, patients can conveniently wear the device when they need it, without the side effects that medication would give. It is STIL’s mission to provide freedom to people who suffer from tremors, allowing them to comfortably live life.


**Keywords:** Artificial Intelligence,Elbow tremor,Shoulder tremor,Arm tremor,Wellbeing,Health,Tremor suppression,Neurological disorders,Orthosis,Parkinson's Disease,Medical devices,Ageing society,Patient care,Essential Tremor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable Public spaces through Inclusive Community Engagement' (SPICE) under Horizon Europe.

assistant: **Objectives**

In order to tackle pressing societal issues, we must reconsider how we design and inhabit our neighbourhoods. The necessity of consistently including end users or local communities is sometimes overlooked in the planning, designing, and construction processes used today. However, combining community knowledge and initiatives can result in more liveable neighbourhoods that empower citizens and represent local needs and surroundings. Furthermore, the way public areas are constructed can have a big influence on how people interact with one another, what kinds of activities happen there, and how much trust the public has in their local government and democracy as a whole. The project seeks to rethink how neighborhoods are designed and experienced by emphasizing the importance of involving local communities in the planning, design, and construction processes. By incorporating community knowledge, more livable spaces can be created that meet local needs and empower residents. Public spaces are vital in fostering social interaction, trust in government, and democratic engagement. Equipping people with the tools to actively participate in co-designing these environments can strengthen social trust, enhance a sense of belonging, and boost community involvement. The ""Sustainable Public Spaces through Inclusive Community Engagement (SPICE)"" project aims to develop a participatory co-creation model for shaping neighborhoods. It will explore and test innovative methods to engage communities in co-designing and maintaining public spaces across diverse European neighborhoods. By promoting interdisciplinary collaboration, leveraging digital tools, and using sustainable construction practices, the project aims to address societal challenges, promote social inclusion, support democrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'High throughput luminescent cytoxicity and apoptosis assays in 384 and 1536 well microplates'.

assistant: **Concept**

This proposal argues the case for a project aimed at developing a range of cyto toxicity assays which are very rapid, free from any hazardous chemicals and which can be performed by laboratory robots in 384 and 1536 well microplate formats. The resultant assays will be developed into diagnostic kits which will be sold to pharmaceutical companies, and medical research institutes in universities and hospitals. The kits will meet the demands of emerging high throughput screening for new drug discovery. There are currently no suitable cytotoxicity procedures capable of measuring cell viability with the speed and sample capacity required by the pharmaceutical industry. The project aims to make major developments to bioluminescent technology involving site directed mutagenesis of biolum inescent enzymes, large scale recombinant production of these enzymes, the development of assay procedures and reagents based on the enzymes and development of novel drying techniques for these reagents. Cytotoxicity testing is applicable to a range of research areas and this project will address a number of these. Specifically, development of cell based cytotoxicity screening assays, a method capable of differentiation between proliferation, necrosis and apoptosis a nd the development of tumour chemosensitivity assays for individual patient tumours. The resultant kits will increase the speed and reduce the cost of new dru g discovery and will provide new rapid analysis procedures for use in cancer therapy. &L&L The kits will facilitate the measurement of thousands of samples per day in a fully automated fashion. They will also provide more information about the mechanisms of cell death than any method currently available. The complete avoidance of hazardous chemicals wili reduce the environme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High performance power conditioner for electricity storage: Optimizedcontrol of charge and discharge currents in renewable energy systems' to be submitted under Fourth Framework.

assistant: **Abstract**

It is the objective of the project to develop a new generation of power electronics for battery based electricity storage systems and thus to extend the life-time of batteries and reduce total life cycle systems costs. The focus of the project is on modifying charge and discharge currents by suitable passive filters, power electronics and charging strategies. An increase of life-time by a factor of two or more has been shown experimentally as a result of changes in charge and discharge conditions. The effects have been explained theoretically using battery models with solid electrodes. Commercially available lead acid batteries will be used in this project, as they are most widely employed and as they will continue to be an important component in any electricity storage system due to their cost and dynamic behaviour. Electricity storage systems in conjunction with sources of renewable energy have to fulfil many different requirements. Optimising charge and discharge currents is only possible if the specific requirements of an application are taken into account. The project will therefore start by defining categories of electricity storage systems with similar operating conditions concerning charging and discharging currents. Installations ranging from the North of Scotland to the Mediterranean will be included in this analysis. Once categories of similar battery operations have been defined, the most suitable type of battery will be selected. Optimised charging and discharging conditions will be determined on the basis of existing know-how in battery technology, taking full account of the specific applications, various restrictions and acceptability to end-users. Under laboratory conditions batteries will be tested using accelerated test procedures to measure improvemen