RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Separating eggshell and its membrane to turn eggshell waste into valuable source materials'.

assistant: **Innovation**

Agricultural waste management is one of the most emerging problems of food processors. The amount of the generated waste as well as the cost of waste disposal is ever increasing across Europe. Egg processors face the problem of the disposal of eggshell waste.According to EC regulations, industrial egg-shell is considered as hazardous waste and it is collected by national authorities. This can induce cost of the order of €100,000 per year in case of small or medium sized egg-processors.However, eggshell is a valuable source material or additive for numerous branches of the industry, such as, among others fodder and fertilizer producers, paper manufacturers. Numerous types of collagens, hyaluronic acid, or amino acids of interest may be extracted from the egg shell membrane and purified for numerous uses (e.g. dietary supplements, cosmetics), which makes the separated eggshell membrane a highly valuable material. This way the egg processors could avoid the cost of waste disposal, moreover they can make extra profit by selling their side product.The main goal of the project is to develop a method for the industrial-scale separation of avian eggshell and its membrane. This core process will be followed by a post-processing (e.g. drying,freezing, etc.) and packaging mechanism to make the way-to-market easy. This will provide an easy solution to the waste problem of egg processors and putting to the market a valuable raw material for the industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An Information Capture and Processing Environment for Chronic Patients in the Information Society' (CHRONIC) targeting Fifth Framework.

assistant: **Abstract**

Our goal is to develop an information environment for the care of chronic patients as an efficient alternative to conventional institutional care, that will improve their quality of life while reducing the huge healthcare costs in the European Union and getting an optimum benefit of information systems technology and culture.The information environment will consists of:1) Personal, safe, friendly and reliable home-based health monitoring systems, providing unrestrained non-intrusive connectivity to the patient.2) Information systems in open communication platforms, adapted to the wide heterogeneity of user needs and profiles, oriented to case management, teleconsultation, advising, rehabilitation and patient training.3) Support systems for diagnostic/therapeutic decision making; for clinical guidelines and protocol and for services quality assessment.The application to other scenarios (acute, terminal patients, elderly, healthy) is emphasised. The chronic care platform proposed will facilitate the outsourcing of services, and thus the growth, of new health-related industries.Objectives:The objective of this proposal is to develop a new European model for the care of chronic patients, based on an integrated information technology environment, that consist of:1.) Safe, friendly and reliable personal home-based health monitoring systems, providing unrestrained non-intrusive connectivity to the patient with efficient communication packaging. They will include sensors and intelligent devices for data handling, decision making and patient status assessment.2.) Systems adapted to the wide heterogeneity of users needs and profiles, based on available infrastructure, that will allow the access to information for case management, teleconsultation, advising, rehabilitation and pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The EBO-PEP project : EBOla Zaïre Post-Exposure Prophylaxis, preparedness and efficacy evaluation during outbreak in Central and West-Africa.' (EBO-PEP), addressing dissemination and exploitation.

assistant: **Impact**

Ebola Virus Disease (EVD) outbreaks represent significant threats to public health and require effective countermeasures to minimize transmission and reduce mortality.The r-VSV-ZEBOV vaccine (Ervebo) demonstrated efficacy in protecting contacts and contacts of contacts and has since been widely used in ring vaccination strategies in the Democratic Republic of Congo (DRC) outbreaks. However, its efficacy for high-risk contact is more and more debated. Furthermore, two monoclonal antibodies (mAbs), Ansuvimab (Ebanga) and REGN-EB3 (Inmazeb), have demonstrated their efficacy as treatment in reducing mortality in patients with EVD. With the availability of these management and prevention tools, the question of their use in Post-Exposure Prophylaxis (PEP), to protect individuals from contracting EVD after a high-risk contact, is more important than ever to effectively control EVD.The EBO-PEP consortium built on a highly successful collaboration between African and European institutions and NGOs. and allow to maintain a network for knowledge sharing and consortium collaboration to fight against EVD in Africa.The overall objective of the EBO-PEP project is to increase the portfolio of therapeutics tools against EVD, by evaluating a PEP strategy for high-risk contact. This will be accomplished through a multi-epidemic, multi-countries phase III clinical trial to test the efficacy of mAbs used as PEP during outbreak period. To address this objective, we focus our activities on 3 specific objectives:- to set up a multi-epidemic, multi-site and multi-countries phase III clinical trial in Africa to test the efficacy of mAbs used as PEP for EVD high-risk contact (EBO-PEP study),- to strengthen the capacities of clinical researchers and increase the knowledge and engagement of the com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Banking Rhizosphere Micro-Organisms. European - Russian initiative to set up a network of rhizosphere microbiological resources centres' in the context of a Seventh Framework call.

assistant: **Objectives**

Soil microbes play key roles in ecosystems and influence ecosystem processes, including nutrient acquisition, nitrogen cycling, carbon cycling, and soil formation. Soil microbes are the majority in soil and a large portion of the genetic diversity on Earth. Many microbes live in association with plant roots and can promote plant productivity and provide protection against stress and disease. Other microbes acts as pathogens and reduce plant growth. Sound environmental and agricultural practices favour balanced composition of biotic agents population in the rhizosphere. Well balanced micro-organisms population favours colonization of soil and nutrients intake, limits occurrence of pathogens (biotic stress), supports the development of commensal or symbiotic relationship between plant and micro-organisms, with a good tempering effect regarding abiotic stress (good water retention capacity, available macro- and micronutrients). Cultivated soils have been extensively studied. Pristine rhizospheres are less studied although these ecological niches contain important micro-flora and -fauna or help conceive the complex ecological microbes-plant relationship in soil, in the rhizosphere. The purposes of this project are:- to organize cooperation between specialised collections containing microbes isolated from the rhizosphere,- to constitute a common wide-range pool of micro-biodiversity exploitable for research and industry: the Pan-European Rhizosphere resources network (PERN).Collaboration between culture collections having material from West-European ecosystems and Russian Biological Resources Centres having micro-organisms from East-European biotopes will create a coordinated network of combined human expertise and culture collections.  The network will offer scientists faci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'High density full diamond cortical implant for long life time implantation'.

assistant: **Concept**

Implantable neuroprosthetic devices offer the promise of restoring neurological functions to disabled individuals. Tests demonstrated that an array of microelectrodes implanted in cortex allows to record activity of the brain and to induce a movement on prosthetic limbs or electrical stimulations restore some visual sensations. For these applications the life time and stability of the electrodes are critical features for the reliable operation of any implantable neuronal device. It’s also necessary to have high density implant with small electrodes to cover a large surface of the cortex to have access of neuronal code. A reliable packaging for long term implantable devices are in titanium or glass but not suitable in the case of ECoG (ElectroCorticoGraphy) implant. Indeed, it is necessary to achieve a polymer implant as a core material, to follow the topology of the brain surface. But in long term the polymer swells and moisture penetrates the implant and degrades its performances therefore reducing the lifetime. The goal of NEURODIAM project is to address two major challenges: - increase the lifetime of implant by a specific packaging, - reduce the size of the electrodes to be equivalent to the neurones size (10 µm) without degradation of noise and consequently increase the electrode density for a fine mapping of the cortex. To avoid performance drift of the implant, a new packaging solution completely hermetic will be developed based on the last developments of micro and nano structuration of diamond layer that combines conductive and intrinsic synthetic diamond. Fast ageing tests will be settled to demonstrate the viability of this diamond technology. In-vitro and in-vivo assessment will be performed to demonstrate the efficiency of these implants for recording and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterizing and harnessing tumor-reactive T cells in the brain' (CENTRIC-BRAIN) under Horizon Europe.

assistant: **Objectives**

Personalized tumor immunotherapy - vaccines and T cell therapies - requires the selection of few immunogenic epitopes recognized by tumor-reactive T cell receptors (TCRs) from thousands of potential tumor antigens in each tumor. This selection is a huge challenge, particularly in brain tumors, where access to tumor tissue is limited and tumor-infiltrating T cells (TILs) are sparse. CENTRIC-BRAIN will reverse this epitope-centric approach by directly harnessing tumor-reactive orphan TCRs from TILs for personalized brain tumor immunotherapy. Using human brain tumor tissue we have developed and experimentally validated predicTCR, a novel approach using machine learning and explainable AI to derive a classifier that predicts tumor-reactivity of such orphan TCRs based on the expression of signature genes with > 90% accuracy across multiple tumour entities. CENTRIC-BRAIN will employ predicTCR to develop a personalized adoptive cell therapy using transgenic T cells with tumor-specific TCRs and improved function. CENTRIC-BRAIN hypothesizes that the signature genes underlying predicTCR determine the phenotypic and functional properties of tumor-reactive T cells and that predicted tumor-reactive orphan TCRs can be employed for adoptive therapy with personalized TCR-transgenic T cells.Aim 1 will refine predicTCR by characterizing the transcriptional programs and spatial distribution of tumor-reactive T cells in human brain tumor samples. Aim 2 will define the functional relevance of transcriptional programs for tumor-reactive T cells in syngeneic humanized and patient-derived xenograft brain tumor models. Aim 3 will validate the predicted tumor-reactive orphan TCRs by adoptive transfer of T cells genetically engineered to express predicted tumor-reactive TCRs. CENTRIC-BRAIN will t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FAbrication, Irradiation and Reprocessing of FUELS and targets for transmutation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

FAbrication, Irradiation and Reprocessing of FUELS and targets for transmutation (FAIRFUELS) provides a way towards a more efficient use of fissile material in nuclear reactors with a view to reducing the volume and hazard of high level long-lived radioactive waste, closing the nuclear fuel cycle.  In order to contribute to the competitiveness of Europe, the Collaborative Project FAIRFUELS will conduct appropriate studies in synergy with other fuel and actinide partitioning & transmutation projects while maintaining close links with Gen IV International Forum. In fabrication technology and assessment of transmutation performance, FAIRFUELS will focus on minor actinides. Dedicated fuels will be fabricated and a fairly comprehensive irradiation programme will be carried out to address transmutation performance. In parallel, FAIRFUELS will conduct Post Irradiation Examination (PIE) of certain previously irradiated fuels and targets to provide in-depth information on their irradiation behaviour. In support of the PIE, modelling aspects of these fuels will be developed.  A training and education programme will also be implemented to share the knowledge among the community, with a link to other related projects. In accordance with the road-mapping exercise undertaken in FP6 and the SNE-TP vision report, the FAIRFUELS consortium, comprising of nuclear research bodies, industry, European Joint Research Centres, and European universities, will endeavour to improve our knowledge in the area of fuels and targets to form a basis for the development of future demonstration systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Selective Molecular Approaches to Remove Trypanosomiasis' (SMART) targeting Horizon 2020.

assistant: **Abstract**

African trypanosomiasis (AT), caused by the protozoan parasite Trypanosoma spp., is a debilitating disease that threatens millions of people in Sub-Saharan Africa. The human disease evolves in two stages, the second of which causes a fatal neurological infection if left untreated. The recent discovery of the orally-bioavailable drug fexinidazole, and its current use as a first-line treatment, has significantly improved disease outcomes associated with AT. However, the risk of resistance to fexinidazole treatment is a major concern that highlights the need for new treatment options. G-quadruplexes (G4s) are non-canonical DNA secondary structures that have recently emerged as an attractive target to fight AT. For example, recent studies have revealed the killing properties of a well-characterised G4-ligand, quarfloxin, against T. brucei parasites, showing the great potential for G4-targeting approaches to treat AT. However, the fundamental role of G4s in trypanosome biology and their validation as therapeutic targets have not been elucidated. In this proposal, I aim to unravel the biological functions of G4s in trypanosomes using integrated chemistry and genomic approaches. Specifically, peptide-based molecules designed to selectively target trypanosome G4s (TG4) will be developed and biophysically validated. The TG4-selective peptides will be used to functionally interrogate the trypanosome genome and to understand the effect of G4-modulation on gene expression using transcriptomics. Finally, our peptides will be engineered into fluorescent probes to facilitate real-time molecular visualisations of TG4s formation in vitro, and to provide an in-depth characterisation of these structures as novel targets to combat AT.


**Keywords:** Trypanosoma brucei, G-quadruplexes, DNA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crossed Memories, Politics of Silence: The Colonial-Liberation Wars in Postcolonial Times' (CROME).

assistant: **Innovation**

Colonial-Liberation Wars generate plural memories, conflicting evocations and persisting amnesias. The project’s main challenge is to produce innovative knowledge about the memories of the wars fought by the Portuguese state and pro-independence African movements between 1961 and 1974/5. The approach chosen is simultaneously diachronic and comparative, inasmuch as it contrasts changes that took place between the end of the conflicts and nowadays, regarding how wars, colonial pasts and anticolonial legacies have been remembered and silenced in Portugal, Angola, Mozambique, Guinea-Bissau, Cape Verde and São Tomé and Principe. The key hypothesis is that wars - as pivotal moments that ended the cycle of Empire in Portugal and started the cycle of African independences in the former Portuguese colonies - triggered memorialisation and silencing processes which had their own historicity. CROME is divided into two strands. The first one, named ‘Colonial Wars, Postcolonial States’, looks at the role played by the states under consideration in mobilising, articulating and recognising the past, but also in actively generating selective representations. ‘Memory as a battlefield’ is the second strand, which will highlight distinct uses of the past and dynamics between social memories and individual memories. The project intends to demonstrate how wars gave rise to multiple memories and conflicting historical judgements, mostly in Portugal, but also to examine how the specific nature of the (post-)colonial histories of each African country has generated different ways to summon war memories and (anti-)colonial legacies. CROME will, thus, put forward a ground-breaking perspective in terms of colonial-liberation war studies, and will be instrumental in dealing with such traumatic exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Graphene to Fight Antimicrobial Resistance' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Today, antimicrobial resistance is emerging as a global burden, endangering our lives. Drug-resistant pathogens kill about 25,000 infected people solely in the European Union every year. In the fight against this crisis, rapid Antimicrobial Susceptibility Testing (AST) plays a crucial role. Although effective in discerning the right concentration of antibiotics required to inhibit the growth of a pathogen, conventional AST techniques are not fit for point-of-care, since they are slow and require large microbial inocula.   The advent of graphene, and the ability to fabricate one-atom thick membranes, has made it possible to make miniaturised sensors that are extremely sensitive to nanoscale forces. During the research project ENIGMA carried out in the framework of the ERC Starting Grant no. 802093, we have developed a methodology that can probe nanomechanical motion of graphene membranes in the presence of bacterial cells.  Here, I propose to further validate this technology and realize a proof-of-concept demonstrator that offers automated high throughput AST using massively parallelized graphene membranes. By eliminating the need for culturing large number of bacterial cells, GRAPHFITI has the potential to shift the current paradigm of AST technologies towards the use of atomically thin membranes with single bacterial cell sensitivity, thus enabling diagnostic tools for fast point-of-care screening of antimicrobial resistance.


**Keywords:** Graphene, Antimicrobial Susceptibility Test, Nanomotion detection