RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Boosting the surface quality and geometric accuracy in laser additive manufacturing via a novel data-driven control system design'.

assistant: **Innovation**

Additive manufacturing has attracted the attention of industries such as aerospace and automotive as well as the medical technology sectors in recent years. Laser additive manufacturing technology (LAM) has become a very promising alternative to high-value large metal components in many manufacturing industries. Although major progress has been made in process development, path slicing, programming, and material analysis, a comprehensive process monitoring, and control system are yet to be developed. BALSAM project (Boosting Accuracy of Laser Additive Manufacturing) aims to provide in-depth methods, models and tools of sensing and control design suitable for the LAM system, including technologies developed for a generic welding process using the candidate previous results on data-driven control methodology. Particular focus is given to the integration of sensor-based feedback control, and how they could be implemented into the LAM process to improve the surface quality and geometric accuracy of the final product. The project concludes with different simulation and experimental results to verify the system’s performance and robustness. The multidisciplinary nature of the BALSAM project is strong, involving a combination of well-developed control, robotics, laser-welding and manufacturing. This proposal includes both the transfer of knowledge to the host institution and the training of the candidate in new advanced techniques. Results have the potential capacity to increase the use of LAM in the European industries and provide room for further studies at the fundamental and applied levels. This project is in line with the EU industrial strategy that aims to make the EU industry more competitive globally.


**Keywords:** Laser additive manufacturing, control engineering, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Novel Detection Scheme to Enable Point of Care Flow Cytometry' (POCYTON).

assistant: **Concept**

In PoCyton, a revolutionary concept for the detection zone of a flow cytometer is proposed. Flow cytometers are fluorescence-based cell counters and as such are indispensable instruments in clinical and biomedical research. Over the last four decades, despite gradual technical improvements in the constituent components, the detection principle has virtually remained unchanged. Fluorescently tagged cells in suspension are made to flow through a narrow focal excitation area and then detected via the fluorescent pulse emitted by them. The narrow focus imposes restrictions on the flow rate and, as a consequence, on feasible sample volumes. Moreover, the alignment of cell-flow, excitation, and detection requires extreme precision. To this end, expensive, bulky components have to be used, preventing substantial miniaturization of flow cytometry. In PoCyton, the detection zone will be enlarged and superimposed with a pseudo-random pattern leading to a temporally extended, distinctly coded signal recorded for each fluorescing cell. In analogy to spread-signal methods, each cell will be reconstructed from the coded signal by correlation techniques. While the precision in spatial cell discrimination outperforms that of conventional flow cytometry only slightly, the signal-to-noise ratio is enhanced significantly, resulting in a notable improvement in sensitivity. In addition, the enlargement of the detection zone dramatically mitigates alignment issues. In PoCyton, various implementations and extensions towards multi-colour flow cytometry will be studied experimentally to demonstrate their high sample-throughput and miniaturization (lab-on-a-chip) potential. Ultimately, a wider range of flow cytometry methods will thus be made available for routine use in clinical laboratories an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'IDIBAPS Doctoral programme Yielding Novel Advancements in Medicine and Innovative Solutions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Addressing the increased need for innovative solutions in medicine requires nurturing and training of highly skilled translational researchers, understanding patients´ needs and driving research to address them, mastering innovative technologies, navigating ethics and regulations, and facilitating interdisciplinary and intersectoral collaborations. The IDIBAPS research institute is uniquely located in the Campus Clínic in Barcelona, joining efforts with the University of Barcelona and the Hospital Clínic, carrying out cutting-edge translational research to improve prevention, diagnosis, and treatment of most common diseases in our society.  The novel DYNAMIS programme will train 10 excellent junior translational researchers to carry out original PhD research projects in Translational Medicine. Recruited through two open, merit-based international competitive calls, the Doctoral Candidates (DCs) will benefit from high-quality co-supervision by a more fundamental and a clinical researcher and will engage in a training and career development programme in a vibrant research and innovation environment, opening them up a wide variety of career paths in academia and the private sector.  DYNAMIS will offer the highest quality standards of scientific integrity and social responsibility, following the principles of the European charter and code for researchers, and the fundamentals of innovative training. DYNAMIS has partnered with 33 Associated Partners, including hospitals, patient groups, SMEs, health clusters and tech companies to offer training, supervision and secondment opportunities, enhancing the employability of the DCs through inter-sectorial exposure. By the end of the doctoral programme, the DYNAMIS fellows will have gained scientific and transferrable skills, includ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A study to identify, quantify and ameliorate the impacts of static gear lost at sea' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This project follows on from work of the study DG-XIV contract 94/95 FAANTARED which assessed the ecosystem impact of ghost fishing" by bottom set gill nets which had been abandoned or lost, and the impact of these nets on benthic habitats in shallow waters. The project extends these investigations to fisheries operating at depths greater than 40 meters and attempts to quantify the impact of ghost fishing mortality on stocks of commercially important species in the gillnet fisheries considered in the project. The impact of lost traps will also be considered to a limited extent in this project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimizing the Delivery of Nanomedicine to Solid Tumors' in the context of a Seventh Framework call.

assistant: **Objectives**

Recent advances in nanotechnology have offered new hope for cancer detection, prevention, and treatment. While the enhanced permeability and retention effect has served as a key rationale for using nanoparticles to treat solid tumors, it does not enable uniform delivery of these particles to all regions of tumors in sufficient quantities. This heterogeneous distribution of therapeutics is a result of physiological barriers presented by the abnormal tumor vasculature and interstitial matrix. These barriers are in large part responsible for the modest survival benefit offered in many cases by clinically approved nanotherapeutics and must be overcome to realize the promise of nanomedicine in patients. More specifically, we need to determine the design criteria - the size, charge and configuration of various nanoparticle platforms - that optimize drug delivery to tumors. Here, I propose the development of a mathematical framework for the delivery of therapeutic nanoparticles to solid tumors. The model will account directly for the properties of the tumor micro-environment as well as for the properties (size, charge and configuration) of nanoparticles to predict their intratumoral distribution. I will specify the model to a human sarcoma and a human mammary carcinoma cell line for which a complete set of experimental data that characterize their micro-environment exists. Informed by these experimental measurements, I will use the mathematical model to construct ""design maps"" that will predict the nanoparticle properties that optimize intratumoral delivery, and thus the efficacy of cancer therapy. I will also employ the model to investigate if modifications in the tumor micro-environment with the use of anti-angiogenic and anti-fibrotic agents can improve the distribution o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis of N-hydroxyheterocycles as starvation agents against highly invasive hypoxic solid tumours' (NOXYCANCERSTARV), addressing dissemination and exploitation.

assistant: **Impact**

The purpose of this research project is the development of preclinical anti-cancer drug candidates able to fight hypoxic solid tumours, which are normally resistant to chemotherapy and radiotherapy. Highly invasive tumour cells are characterized by a metabolic switch, known as the Warburg effect, from “normal” oxidative phosphorylation to an increased anaerobic glycolysis. This ensures a sufficient energy supply from glucose, even in hypoxic environments. One of the key enzymes involved in anaerobic glycolisis, the muscle isoform of lactate dehydrogenase (LDH5), has been recently shown to be overexpressed by metastatic cancer cells, and has been linked to the vitality of tumours in hypoxia. This enzyme may be considered as a valid target for new anticancer agents, since its inhibition would lead to a cut in cancer energy supply, thus reducing its metastatic and invasive potential. A validation of LDH5 as a safe target derives from the observation that in humans, hereditary LDH5 deficiency causes a certain level of myopathy only after intense anaerobic exercise, whereas it does not provoke any symptoms under ordinary circumstances. This project will support a qualified international researcher in the management of a research line including molecular design and synthesis of a series of new compounds, as well as in the participation in the biological evaluation of their properties. Each step of his formation will be adequately followed by additional specialized trainers. The host institution has already identified a suitable structural scaffold, based on N-hydroxyheterocycles, which has furnished some preliminary LDH5 inhibitors, comparable to those observed with the few examples known in literature. This scaffold constitutes the basis for the development of a large series
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High Precision Simulation of particle collisions at the LHC' (MCATNNLO) under Seventh Framework.

assistant: **Objectives**

The recent discovery of a Higgs-boson like resonance at the Large Hadron Collider (LHC) at CERN is a major landmark in the quest to understand the fundamental nature of the Universe. Precise measurements of the properties of the new boson are now mandatory and must be reflected in a similar quest for higher precision from the theory side. We aim to meet this challenge by developing a theoretical framework together with suitable high-precision tools that will guarantee the continued success of the LHC programme.The aim of this proposal is therefore to develop and establish a new standard of theoretical precision in the description of physical observables at the LHC and other particle collider experiments, thereby leading to a more precise extraction of fundamental physics parameters, such as the couplings of the Higgs boson to other fundamental particles.   The necessary theoretical precision will be achieved by systematically including the next-to-next-to leading order (NNLO) corrections in the perturbative expansion in the relevant simulation tools, focusing on crucialexperimental benchmark processes.The techniques and frameworks we will develop will be applicable to other processes and in particular, will be very relevant to searches for physics beyond the Standard Model, and in the further interpretation of any signals that would indicate such a discovery.To achieve this ambitious goal, the PI will work very closely with a team of carefully chosen scientists with relevant overlapping and complementary expertise in precision calculations and event simulation: Professor Dr Thomas Gehrmann (University of Zürich), Professor Dr Aude Gehrmann-De Ridder (ETH Zürich) and Dr Frank Krauss (Durham University).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Creativity for Innovation & Growth in Europe' (2007-2013).

assistant: **Concept**

Creativity is a fundamental transformative mechanism of the European economy.  To study this mechanism, this project brings together 11 of Europe’s leading innovation research centres, and is structured around six themes: 1. Mapping and measuring the creative-cultural industries and their impacts; 2. Understanding and modelling creativity and design; 3. Entrepreneurship and industrial dynamics in the creative-cultural industries; 4. Digital ecosystems, user participation and the blurring of production and consumption; 5. Intellectual property, IP rights and innovation in creative-cultural activities, and, 6. Policy issues and recommendations.  Together, and through nearly 25 person years of research, we will make substantial progress in methodologies and provide fresh and integrated approaches in the study of creativity and innovation, as well as in the dynamics of these industries.  This will result in new data sets, policy briefs and tools, as well as academic articles and books.  Above all, the project will substantially enhance the state of knowledge and understanding of the nature and characteristics of creativity and innovation, the cultural-creative industries, and their role in shaping the future European economy and society.  It will also provide important and reliable evidence regarding the emergence, promotion and stimulation of creativity in relation to innovation in Europe, and how creativity-based entrepreneurship contributes to economic growth and wellbeing. The project will also be a highly valuable and original source of knowledge and understanding for the research, business and policymaking communities at both the EU and national / regional levels.  The project will also help build a European research community focused on creativity and innovation, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reliable and Efficient Dual Fuel System for Civil Protection during Natural Disasters using HT-PEM Technology' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This proposal entitled “RESCUE – Reliable and Efficient Dual Fuel System for Civil Protection during Natural Disasters using HT-PEM Technology” is about the development and the demonstration of a fuel cell system which allows the operation using 100% of hydrogen and additionally using methanol and assures 50 kW of electrical power. The containerised and modular design in combination with the duel fuel approach leads to an application flexibility for various important facilities during natural disasters like the civil protection with different energy requirements. The HT-PEM technology is characterised by increased operating temperature of around 160 °C and enables a simplified cell design and operation regarding water management, heat rejection and direct use of reformates.After system requirements (WP2), the fuel cell module equipped with the fueling possibilities will be constructed and tested in laboratory environment (WP3). After fuel cell and fuel container contructions (WP4), the system integration (WP5) considering safety and transport certification requirements (WP2/9), demonstration using defined load profiles and conditions with performing grid integration is planned (WP6). Testing for at least 2,000 hours on site of a civil protection organisation shows the system capabilities and completes the project (WP7). State-of-Health against the criterium of system efficiency and fuel flexibility on system and on fuel cell level is analysed and accompanies the whole project duration (WP8). Dissemination and exploitation are mandatory in this project (WP10).


**Keywords:** Hydrogen, Methanol, Fuel Cells, HT-PEMFC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Rapid chip-based detection of antibiotic resistances' (ResisCHIP) under Horizon Europe.

assistant: **Objectives**

Drug-resistant infections are one of the greatest threats facing humanity. Antimicrobial resistance (AMR) causes over 700.000 deaths each year. Furthermore, AMR is associated to reduced quality of life, increased hospitalization periods and medical costs.  Misuse and over-prescription of antibiotics for human or animal treatment are one of the drivers of AMR.  At the same time, the development of new antibiotics is virtually nonexistent. Hence, developing fast diagnostic methods to identify the optimal treatment is key to effectively fight AMR and increase survival rates of patients encountering life-threatening infections. So far, diagnostics rely on bacterial cultures, leading to slow turnaround times, which are linked to the preventive administration of broad-spectrum antibiotics, often inefficient and leading to worse disease outcomes and spread of AMR. Novel approaches such as DNA PCR-based diagnostic panels or next generation sequencing methods have been recently proposed to address this issue. However, they are target a limited number of pathogens and genes or require expensive equipment and highly-trained personnel. Furthermore, they require a culture step to reach detection levels, usually lasting a few hours, that can be critical for serious conditions. Recently, using technology derived from ERC StG and PoC grants, we designed a method to concentrate, purify, and isolate bacterial RNA in just 5 minutes. Here, we seek to develop and validate these tools, combined with a rapid RNA chip array with single-molecule resolution, to provide a culture-free, fast, and highly sensitive alternative to bacterial infection diagnostics from direct blood samples. Once developed, ResisCHIP will provide a tailor-made diagnostic kit with the capacity to identify thousands of ge