RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Supporting Independently Living Citizens'.

assistant: **Innovation**

The percentage of old and very old persons in the population is increasing in most European countries. At the same time, most ageing persons want to continue to live in their own home for as long as possible. As many older persons live in single-person households, ways and means have to be found to their ensure personal safety and to support their activities of daily living. SILC will produce an alarm system based on a wrist-worn electronic device that has integrated innovative biometric sensors, and that monitors the pulse, temperature, and acceleration; other sensor signals can be added later. Via a telecommunication link, it will be possible to trigger an alarm call in the event that critical conditions are detected. Increased value as an encouragement to permanent use is provided by integrating cordless telephone operation, and environmental control functionality, under a user-friendly interface designed to support disabled and elderly people.Objectives:The SILC project aims at developing an innovative and intelligent alarm system to increase the safety and independence of elderly and disabled citizens. In contrast to existing alarm phones, SILC will be equipped with a range of biometric sensors which can be programmed individually to trigger an alarm call automatically when a critical situation is detected. In order to increase the benefit to the user beyond the alarm function several additional utilities - like a cordless phone, environmental control functionality, and personal digital assistant-like functions - combined with an intuitive user interface will be integrated to facilitate safe and independent living at home. In general, SILC will foster and facilitate senior citizens' capacity to stay longer in their own household before institutional care becomes ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Information and publicity helping the objective of reducing motorised mobility' in the context of a Fourth Framework call.

assistant: **Objectives**

The overall aim of the research is to produce Guidelines showing how to use various kinds of information and publicity campaigns in order to reduce dependence on the car and levels of motorised mobility. Such campaigns might be initiated by a range of public or private sector organisations, using a variety of tools aimed at different target audiences, either with the objective of increasing use of non-car transport modes (public transport, walking and cycling) or aiming directly at reducing car use.The seven specific objectives are:1. To provide a generic classification of information and publicity tools that can be applied in a transport context to influence travel behaviour.2. To identify key target and the ways in which travel behaviour might be influenced by information and publicity initiatives.3. To provide a comprehensive review of different kinds of information and publicity campaigns, and the policy objectives they have been intended to achieve.4. To identify and detail a range of case studies, illustrating good (and bad) practice.5. To develop a general model setting out relationships between objectives, information and publicity strategies, use of specific tools and likely behavioural outcomes.6. To develop a number of 'concept campaigns', to illustrate how the principles derived under the general model might be applied in selected situations.7. To ensure widespread dissemination of the of the findings among relevant public and private sector organisations. %case studies will be decided in the course of the project %Links have been established with the parallel project CAMPARIE, in relation to the conceptual framework for the task and with the aim of some common dissemination elements. It is expected that some inputs will be derived from WALCYNG and ADONIS (T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Hemodynamics in an Infarcted heart: from multi-physics Simulations to Medical analysis'.

assistant: **Innovation**

The left ventricle is the principal mechanical element of the human heart that propels blood to the systemic circulation. Its contraction is the result of an electrical wave propagation generated at the cellular level and is studied in the framework of cardiac electrophysiology. This science is nowadays mature and provides models to capture and reproduce the contraction/relaxation cycle of the heart that are used for a quantitative understanding of the heart functioning. However, these electrophysiology models do not include the hemodynamics caused by the ventricle deformation, thus neglecting the fundamental vortex dynamics taking place in the heart physiology, which generates stresses on the surrounding cardiac tissue.     This project aims at connecting the electrophysiology and the fluid mechanics building an electro-fluid-structure computational model for the pulsatile flow in an animated left ventricle and elastic aorta.  Biological heart conditions will be reproduced as close as possible by merging my electrophysiology code with the advanced fluid-structure framework of the Physics of Fluids group (PoF) at University of Twente (UT). The resulting multi-physics model will allow studying the accurate hemodynamics and cardiac tissue stresses generated in an animated ventricle. Building on my experience in vortex dynamics, we will correlate the topology of the vorticity structures with the heart functional pumping and then study how cardiac diseases such as myocardium infarction modify them, accounting for infarction location and sex differences.      The outcomes of HI-SiMed will provide the medical community with an innovative and advanced tool that could open new horizons for the improvement of treatment outcomes. With this ambitious aim, the project will be devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterization of a planar polarity-signalling cascade in the Arabidopsis root epidermis' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Planar polarity, the polar orientation of cells within the plane of a tissue layer, is intensively studied in animals, but little is known about planar epidermal polarity in plants. We study polar root hair positioning close to distal ends of hair-forming cells (trichoblasts) in the Arabidopsis root epidermis. We have isolated the recessive beatnik (btk) mutant that displays root-specific phenotypes such as long hairs and hyperpolarized hair initiation at distal-most ends of trichoblasts. Map-based cloning, sequencing and complementation of btk revealed that the phenotypes are caused by a novel mis-sense mutation in the protein kinase domain of CONSTITUTIVE TRIPLE RESPONSE1 (CTR1), a RAF kinase acting as a negative regulator of ethylene signalling. Unlike other ctr1 alleles, btk does not display a constitutive triple response thus representing a unique CTR1 allele. Immuno-localization of ROP (RHO-of-plant) small GTPases in btk showed premature hyperpolarized localization to hair initiation sites prior to cell elongation. These findings suggest that CTR1 acts upstream of polar ROP positioning and couples planar polarity to cell elongation.We propose to analyse the molecular basis of the btk phenotype by determining in vivo protein kinase activity, stability and changes in sub-cellular localization of epitope-tagged CTR1 wild type and btk mutant proteins. Genetic analyses combining btk and other planar polarity mutants (aux1, ein2, act2 etc.) will be employed to place CTR1 action into a signalling cascade. Cre/Lox based mosaic analysis of ctr1-1 and btk loss-of-function and CTR1 over-expression clones should answer where CTR1 modulates planar polarity and whether this involves cell autonomous action. These studies will be extended to btk mosaic analysis in aux1 and e in2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modulating the behaviour of cancer myofibroblasts to control tumour desmoplasia' (MYO-DESMOPLASIA).

assistant: **Innovation**

In many tumors a desmoplastic reaction takes place during progression, which results in extensive production of collagen by stromal cells of the tumor, mainly fibroblasts and myofibroblasts. Tumor desmoplasia determines in large part the patho-physiology of solid tumors and poses a major barrier to effective drug delivery, affecting the overall survival of cancer patients. Here, the applicant proposes to test the hypothesis that the increase in extracellular matrix (ECM) stiffness and transforming growth factor-beta (TGFβ) activation often observed during tumor progression have additive effects on tumor desmoplasia. Therefore, targeting any of these parameters alone or in combination can reduce the desmoplastic response of the stromal cells. To explore this hypothesis, a combination of cutting-edge techniques will be employed. Specifically, a collagen ECM model, with pre-determined topography and tunable stiffness will be developed. Subsequently, fibroblasts and myofibroblasts will be cultured in the ECM models. Cells nano-mechanical behavior and their morphodynamic alterations will be investigated with Atomic Force Microscopy and light/fluorescence microscopy under the presence or absence of TGFβ or anti-TGFβ agents. Finally, the effects of matrix stiffness along with different TGFβ concentrations in the expression pattern of genes encoding ECM components will be investigated using real-time PCR. The research results will elucidate the mechanisms of the interplay between matrix stiffness and TGFβ production in modulating the ability of fibroblasts and myofibroblasts to form tumor desmoplasia. In the proposed project, the fellow will acquire scientific and complementary skills according to his personalized career development plan and through advanced training, internati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative green wood treatment" to achieve Risk Class4 protection"' to be submitted under Sixth Framework.

assistant: **Abstract**

In Western Europe, there is a growing interest and market for wood construction since timber is available and consumers are attracted by the environmentally-friendly image and advantages of wood. While traditional construction is mainly led by big companies manufacturing concrete, sawn-wood activity is most favourable to the development of SMEs along the whole forest-wood chain". Yet, there are many barriers to overcome to make wood competitive and adopted by a larger amount of consumers. One of them is the deterioration of the material when exposed to outdoor conditions requiring protection with special treatments.These treatments include biocides (formerly known as non-agricultural pesticides) used to destroy and exert a controlling effect on any harmful organism by chemical or biological means. They are still widely used in most of the countries, but the tendency in the future is to control their use. Currently, the highest level of biological protection, Class Risk 4 can be reached only with treatments that inject in the wood toxic products such as creosote, pentachlorophenol or hydrosoluble salts.The project will provide the wood industry with an innovative, safe and efficient solution for the in depth protection of wood against biological predators by using a green chemical process applicable by the SMEs without risks. This solution, completed with a surface coating, will satisfy Risk Class 4 protection and provide a new scientific base for the application of the European Directives controlling and reducing the use of chemical compounds that are toxic to humans, animals and the environment. Hence, over a thousand SMEs from several European countries (Spain, France, Lithuania, Estonia, Sweden and Romania) members of the six IAGs of the consortium will be able to ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'European conference on personality'.

assistant: **Concept**

The overall objective of the European Conference on Personality is to bring together personality psychologists from applied and basic fields and to develop efficient research networks among them.In the last decade numerous psychologists throughout Europe have initiated research programs aiming to contribute to the understanding and solution of societal problems that all European states are facing like efficient use and training of workforce, widespread stress reaction in work and home environments, criminality, prevention of physical and psychological illness, immigration, and xenophobia. The study of individual differences (personality variables) is an important facet of this research. Since there is a tendency that personality constructs are increasingly studied outside the field of personality psychology this conference aims at bringing together psychologists from European countries that are involved in personality research. Setting up research networks and enhancing the exchange among researchers in diverse fields of psychological research is the basic aim of the European Conference on Personality.There will be an interchange between basic and applied researchers. On the one hand, this conference focuses on those aspects of personality that are important to many research programs: the structure and measurement of personality traits, personality change and development, the aetiology of personality traits. On the other hand, researchers in more applied fields will present their approaches and results. This interchange is extremely important mainly for three reasons: First, to yield a high level of expertise in applied research, second, to avoid the costly parallel development of theories and research methods, and finally, to contribute to the development and testing o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Precision and interpretation of signaling in embryonic development of the vertebrate nervous system' under Sixth Framework.

assistant: **Concept**

Of great importance during embryonic development are secreted signaling molecules that control the differentiation, proliferation and patterning of forming tissues. Many of these signals act in a graded fashion to control cell behaviour in a concentration dependent manner. Sonic Hedgehog (Shh) is an example of such a signal that controls the generation of distinct neuronal subtypes in the neural tube. In response to Shh signalling, the ventral neural tube is divided into compartmentalised progenitor pools, e ach of which generates distinct neuronal progeny. The boundaries between adjacent progenitor pools are delimited by sharp, patent changes in gene expression and the remarkable precision of these boundaries, together with the absence of intermixing of cells from adjacent pools, represents a critical step in the interpretation of graded Shh signalling. Here we aim to determine the mechanisms involved in this poorly understood process. We will focus on the role of cell-cell contact and differential cell adhesion. To this end, we will develop novel in vitro and in vivo approaches that combine state-of-the-art live imaging techniques and the latest chick transgenic technology. These will allow me to assay this process and provide powerful functional tests for candidate molecules and analysis of the epistatic relationships between the different molecular partners. The project addresses questions that are at the forefront of research in developmental neurobiology, and more generally in biology. Knowledge of the mechanisms that confer precision to graded Shh signalling will advance our understanding of neural tube development and provide insight into general strategies that endow morphogen gradients with their extraordinary accuracy. Moreover, the basic science quest ions a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel high-performance enzymes and micro-organisms for conversion of lignocellulosic biomass to bioethanol' (NEMO) targeting Seventh Framework.

assistant: **Abstract**

The NEMO project provides novel efficient enzymes and microbes for 2nd generation bioethanol production. It generates through metabolic engineering and mutagenesis & screening approaches robust yeast strains that have a broad substrate range and can (co-)ferment C6 and C5 sugars to ethanol with high productivity (rate and yield), and that are significantly more stress tolerant, i.e. inhibitor, ethanol and thermotolerant than the current S.cerevisiae strains used in ethanol production. The NEMO project also identifies and improves enzymes for hydrolysis of biomasses relevant for Europe. Novel enzymes are identified and improved through various approaches, based on screening, broad comparative genomics analyses, and protein engineering. These efforts will generate more thermostable enzymes for high temperature hydrolysis, more efficient enzymes for hydrolysis of the resistant structures in lignocellulose such as crystalline cellulose and lignin-hemicellulose complexes, enzymes with reduced affinity on lignin, and efficient thermo and mesophilic enzyme mixtures that are optimised and tailor-made for the relevant biomasses for Europe and European industry. These novel biocatalysts are tested in an iterative manner in process relevant conditions, including also pilot-scale operations, which ensure that the novel enzymes and microbes will be superior in real process conditions. Furthermore, optimal enzyme, microbe and process regime combinations are identified, providing basis for the development of the most economic and ecoefficient overall processes. The impact of the NEMO project on 2nd generation bioethanol production is significant because it provides most realistic but widely applicable technologies that could be exploited broadly by European industry. Its impact goes a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Research, Intelligence and Technology for Heritage and Market Security'.

assistant: **Innovation**

RITHMS project intends to boost the operational capacity of Police and Customs/Border Authorities in addressing the increasingly organised and poly-criminal nature of trafficking in cultural goods through research, technological innovation, outreach and training.Illicit trade in cultural heritage has progressed from a local phenomenon limited to the initiative of a few individuals to a highly remunerative source of income for criminal organisations and terrorist groups that have taken advantage of the opportunities offered by the web and social media to further expand an already flourishing market. Against this background, RITHMS proposes an interdisciplinary approach made necessary by the transnational character of this crime and its links to other criminal networks. The project will define a replicable strategy to counter the challenges in addressing the illicit trafficking of stolen/looted cultural goods and to investigate the mechanisms underpinning it, including its connection with organised crime. RITHMS will foster cross-cutting research bringing together all the domains relevant to expand the understanding of this type of crime (art market, criminology, law studies, forensic science, etc.). Inputs from these disciplines will inform the theoretical framework underlying an interoperable AI-based Platform able to identify criminal organised networks and to provide investigators with valuable intelligence on the activities and evolution of such networks. The Platform will be leveraging the methods of Social Network Analysis (SNA), a methodology that gives a way to better understand human behaviour through people's relations and interactions.  Including four Police authorities, two Border Agencies, one Police School, SMEs, and researchers from SSH and ICT, RITHMS Con