RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Harnessing the cognitive and neurophysiological processes characterising the sleep onset period' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Sleep often escapes us when we need it or intrudes when we would prefer to stay awake. What if we could control when we fall asleep? While our understanding of sleep has rapidly grown, what happens during the wake to sleep transition remains mysterious, potentially due to the widespread assumption that we are either awake or asleep. The current standard is to define vigilance states through coarse, physiological criteria that are visually assessed on fixed, 30s-epochs. In this framework, the sleep onset period (SOP) typically corresponds to the first sleep stage. Yet, this classification in discrete sleep stages fails to account for the gradual, dynamic changes observed in the descent to sleep, on the behavioral (reduced responsiveness to stimuli), subjective (dream-like experiences called hypnagogia) and cognitive level (decline in executive functions, enhanced creativity).To better understand how we transition from full vigilance to sleep, I propose to integrate, within the same framework the many dimensions of the sleep onset process. I hypothesize that the behavioral, subjective, and cognitive changes associated with the SOP are each reflected by specific neurophysiological signatures that are partially independent of sleep stages. I recently found candidate physiological markers for the different SOP dimensions. In CREADOZE, I will leverage on these findings to refine in space and time the neurophysiological signatures reflecting the processes which decline (behavioral responsiveness, executive abilities) and those which emerge (hypnagogia, creativity) during the SOP, using multimodal physiological recordings. I will explore how these markers fluctuate in relation to each other and identify potential factors influencing them (sleep pressure; sleep disorder).  Then,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adenovirus mediated gene transfer and iological active peptides: nrw potential approaches to the treatment of hyperplasia after vascular injury' to be submitted under Fourth Framework.

assistant: **Abstract**

. To determine the role of gene therapy in preventing and/or treating intimal hyperplasia (IH) developing after angioplasty or arterial bypass surgery.. To examine the effects of replication-deficient adenovirus vector (Ad-v) and biologically active peptides (AP) alone or in combination a) to accelerate reendothelialization at the vascular injury site (Ad-v mediated transfer of vascular endothelial growth factor and platelet-derived endothelial cell growth factor cDNA), b) to inhibit the binding of specific growth factors to their receptors (Ad-v mediated transfer of antisense to insulin-like growth factor receptor type 1, AP analogue of IGF-1 and bFGF) on vascular smooth muscle cells (VSMC), c) to induce VSMC failure to progress through the cell cycle (Ad-v mediated transfer of wild-type p53 cDNA) and d) to induce VSMC failure to migrate from the media to the intima (Ad-v mediated transfer of tissue inhibitor of metalloproteinases type 2).The biologic effects of Ad vectors and APs will first be assessed in tissue culture experiments. The Ad-vs and APs with the expected biologic effect in vitro will then be tested in the rat carotid artery injury model of IH. In these studies Ad-vs will be delivered in the lumen of the carotid artery at the time of endothelial denudation, while APs (that require a prolonged time of action) will be administered sistemically via an osmotic pump placed subcutaneously. These experiments will determine those Ad-vs and APs most effective in preventing IH without causing significant side effects. A third group of rats will be similarly treated with a combination of the most active Ad-v and AP to demonstrate or exclude any additive or synergistic effect in the final phase of our study the Ad-v and the AP which appear most promising for clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Vaccines and Imaging Partnership' in the context of a Seventh Framework call.

assistant: **Objectives**

There exists an urgent need to advance methods for detection of bacteria in the body, primarily in the context of infectious disease research. Real-time in vivo analysis empowers the investigator with the ability to non-invasively assess bacterial activity over time, as well as host responses to infection and interventions. Optical Imaging (OI) modalities are based on the detection and quantification of bioluminescent or fluorescent light from the subject and represent powerful yet cost-efficient and convenient systems. By labelling of bacteria and/or host cells of interest, both bacterial and host responses can be assessed in rapid, high-throughput analyses, providing spatial, temporal and quantitative read-out, without the need for radioactivity. There is a large and increasing market need for efficient reagents for in vivo bacterial imaging.We aim to develop improved in vivo imaging and ex vivo analysis methods for the study of bacterial infectious diseases and host immune response to infections, to address the current need across the range of fields of infectious disease and vaccine research. A broad skill set is required in this rapidly advancing field, involving exposure to laboratory science, imaging technology, commercialisation of research and industrial processes. By bringing together an international network of leaders in the fields of molecular imaging, infectious disease, vaccine research and industry, we propose to address the current paucity of technology for imaging of bacteria in research animals. Novartis is a world leader in development of vaccines for infectious diseases, and will provide an industrial steer from the project outset. Through combining the various specialities of this IAPP, the proposed work programme will facilitate transfer of knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of real time specification' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

ARTS will address the Software Intensive System Engineering aspects that are crucial in the development of safety critical and embedded real-time applications: verification and validation (V&V) of both the user requirements and the final systems. In particular, ARTS will address these aspects in the avionics field, where safety critical requirements impose analysis of consistency and adequacy during the whole application life cycle.In the project a formal specification and test technique based on a temporal logical framework (TRIO) will be applied to critical phases of the V&V process for an Electrical Flight Control System (EFCS). This application will be developed using conventional techniques within an industrial development project which was started in 1994 and will be completed in 1998. ARTS will allow the user and the system developer to experiment with TRIO for testing both specification and implementation of critical components of EFCS. The use of TRIO on EFCS applications is completely new, since it has so far been applied in energy management systems only. TRIO has been developed within an RTD project, supported mainly by ENEL - the Italian electricity company - and has been used for the specification of real time, safety critical systems devoted to control, power production, transport and distribution.The action aims at verifying that TRIO can satisfy specific needs - related to V&V activities in the avionics field - that conventional techniques cannot. The link with the real EFCS development project will allow a concrete evaluation of benefits and difficulties implied by the use of TRIO. On the basis of this evaluation, a methodology which integrates traditional design practice with TRIO-based formal V&V activities will be explored. To merge existing techniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A data-driven remanufacturing process for sheet metal and thermoplastic composites' in the context of a Horizon Europe call.

assistant: **Objectives**

The COMPASS project is driven by the needs to on the one hand increase the efficiency of recycling and remanufacturing processes (for sheet metal parts) and on the other hand by the need to find a solution for large quantities of thermoplastic fibre-reinforced components at their end of life. In both cases the proposed approach is to take a shortcut by remanufacturing the components at the level of sheet metal and composite panels instead of converting them to secondary raw material. This will be achieved through (thermo-)forming processes that allow the re-shaping of parts and components to give them a second and third life. These remanufacturing processes will be supported by a set of digital tools that build upon a digital component passport. The tools will enable efficient dismantling processes to extract sheets or panels e.g. from an aircraft and will help to collect relevant information about the components during their lifetime. The main use cases are from the aerospace and automotive sector and include key actors along the value chain. By using digital information about defects, re-work or repair done during the lifetime of the components. The quality of the resulting, remanufactured output parts will be optimized.  A remanufacturing process planning software will also optimize the match between input components and targeted output parts.The COMPASS project will initiate more than 6M€ of private investments in technology development and implementation of remanufacturing process in the use cases investigated in the project. The overall goal is to enable the remanufacturing of about 30% of sheet metal parts and thermoplastic composite panels.


**Keywords:** sheet metal, thermoplastic composites, digital component passport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Engine Waste Heat Recovery and Re-Use' (NOWASTE) targeting Seventh Framework.

assistant: **Abstract**

The reduction of CO2 emissions from road vehicles is a strategic goal of the EU, and heavy duty vehicles are required to contribute to this objective in a significant way.One very promising solution is the re-use of the waste heat, which represents approx. the 60% of the combustion energy, by transforming it into mechanical or electrical energy thus increasing the overall vehicle energy efficiency directly. Depending on the operational conditions, fuel consumption and hence CO2 emissions can be reduced by between 10% and 15%. Such benefits can be higher in the case of a hybrid or hybrid-like powertrain where it is possible to store and then use the generated energy subsequently when most convenient.Heat re-use can be performed by means of a thermodynamic cycle (e.g. organic or non-organic Rankine cycles) using the waste heat as a source of energy, as is already being developed for application in large stationary applications. The adoption of such technology in the automotive domain requires specific R&D activities to develop the components and identify the most appropriate system architectures and level of integration in order to achieve sustainable costs and the required level of reliability.ObjectivesThe NoWaste Project aims to develop such an engine waste hear recovery and re-use system for automotive applications and demonstrate its feasibility within both a purpose-built test rig and a vehicle demonstrator.The key points of the NoWaste Project are:• definition of a reference mission• selection of the most appropriate architecture following an in-depth technology screening• innovative heat rejection system minimizing the cooling drag and the impact on the front end• development of specific heat exchangers to maximize the heat recuperation efficiency• integration wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing Compassionate Workplaces in Europe for the digital and green work environment to protect employees’ mental and physical health and wellbeing' (EU-CoWork) under Horizon Europe.

assistant: **Objectives**

EU-CoWork aims 1) to explore and understand the influence of changing workplace organization due to the twin transitions on well-being, performance, job quality, and work culture for employees confronted with serious illness, family caregiving, death, dying and loss (EoL experiences) and their colleagues; and 2) to develop and evaluate tailored Compassionate Workplaces Programs (CWPs) as health promotion strategies to maintain and support employee health and wellbeing in the work environment, across different national and labour contexts in Europe. The core of this project is a 4-country cross-national mixed-methods intervention study with an embedded process and impact evaluation. The project consists of 2 separate studies that feed into each other: a) an international co-creative and developmental evaluation of tailored CWPs, and b) an international mixed methods process and impact evaluation combining a timed series of quantitative cross-sectional panel surveys, qualitative interviews and fieldwork, and policy document analysis. Tailored CWPs will be developed in 12 European workplaces. EU-CoWork will provide findings about workplace compassion and mental and physical health and wellbeing of European employees in several working sectors, and the relationship between workplace characteristics and compassion at work and the health and wellbeing of employees confronted (directly or indirectly) with EoL experiences. The project will collect data about the relationship between employees’ EoL experiences, the company’s responses to these experiences and company and employee performance, and about the variability in workplace policies in Europe that address such risk factors. EU-CoWork will thereby offer insights and building blocks needed to create work environments that e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Helical Alleno-Acetylenic Oligomers with High Chiroptical Activity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The principal goal of this proposed Marie Curie project is to develop a new class of structurally-stable chiral macromolecules—alleno acetylenic oligomers—with an all-carbon backbone and rigid helical secondary structure that will result in high optical activity. We wish to explore and attain a thorough understanding of the factors that allow a significant increase in the optical activity of these materials. This will be achieved by stabilizing their secondary helical structure by the means described below in the proposal, and by forming assemblies of these helices to yield superstructures, in which the optical activity will be increased as a result of cooperative effects. This research project will provide an innovative route for the synthesis of new structurally-stable helical foldamers, where several strategies will be applied: (i) covalent crosslinking using ring closure metathesis (RMC), (ii) non-covalent cross linking using hydrogen and halogen bonding, (iii) coordinative cross linking, (iv) solvophobic interaction – using various solubilizing groups. Considering the high chiral activity reported for the parent oligomer, the structural stabilization of the crosslinked oligomers and the formation of ordered superstructures are expected to result in novel, optically active oligomeric geometries with record-high chiral activities.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Infradev - European Paediatric Translational Research Infrastructure'.

assistant: **Concept**

The general objective of this project is to design the framework for the European Paediatric Translational Research Infrastructure (EPTRI), a new Research Infrastructure (RI) aimed to enhance technology-driven paediatric research in discovery and early development phases to be translated into clinical research and paediatric use of medicines.The starting point of the proposal is the serious lack of medicines for children in EU and worldwide as well as the lack of a developmental model for paediatric medicines that integrates technology-driven aspects with the methodological, ethical and regulatory framework. The design for this new RI will be based on the following main pillars:•to harness efficiency and delivery of paediatric research activities and services strengthening collaboration within the scientific paediatric community;•to be a complementary RI in the context of the existing RIs covering the current gaps, while avoiding any duplication;•to develop a one-stop-shop for advice in paediatric drug development.To prepare a valuable Conceptual Design Report (CDR), the project encompasses three phases. During the Context Analysis phase, that will be performed in 5 technical and scientific domains (1- Paediatric Medicines Discovery, 2- Paediatric Biomarkers and Biosamples, 3-Developmental Pharmacology, 4-Paediatric Medicines Formulations and Medical Devices, 5-  Underpinning Medicines Development to Paediatric Clinical Studies) the perceived value and the possible gaps to be covered will be estimated by enquiring the scientific communities and many other Stakeholders.During the Operational phase, the different components of the new RI will be depicted including governance model strategies for interaction with national Authorities and the existing RIs, the IT-architectu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Working group on quality and information technology'.

assistant: **Innovation**

The objective of Q&IT2 is to exploit Quality concepts, methods and techniques by enterprises, using the possibilities offered by IT. The working group will carry out promotion, awareness and dissemination activities to enhance the exploitation of research results in 'Quality and IT' and to facilitate quality management up-take by European industrial enterprises, with a special focus on SMEs.Q&IT2 addresses three basic up stream elements of the value-chain in quality and IT uptake, - R&D, by identifying synergies between projects and collecting users' requirements; - Results promotion/dissemination, by organising joint actions and by collaborating with existing initiatives; - Recommendations for future activities. The main objectives of the project are, - To integrate new ESPRIT IiM quality projects into the quality cluster; - To collect quality information in several industrial sectors; - To reduce an updated 'road map' of R&D in 'Quality and IT'; - To propose an approach to the production of unified public deliverables of quality projects; - To develop an efficient collaboration with the network of excellence ICIMS-NOE; - To develop a WWW page on 'Quality and IT' activities and results; - To organise 'Quality and IT' workshops, and to promote quality and industrial exploitation; - To promote material to support 'Quality and IT' activities;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BESTAS2 - stimulating SME participation in Framework 5' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

BESTAS2 follows up the current successful CRAFT stimulation action Project BESTAS due to end in July 2000. BESTAS2 aims to continue proposal stimulation to the end of the FPS (E.g. 2002) and extend its geographical range by adding three new partners from Czech Republic, Hungary and Slovenia. The new partners will be trained in the current and innovative practices of the existing BESTAS partners. Overall objectives are to strengthen the innovative capacity of SMEs in the EU and Central and Eastern European States Five brokerage events will be held to build transnational partnerships focussing on developing FP5 RTD projects