RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Visionary roadmaps: Crafting an Inclusive and Participatory European Democracy with Youth and Communities (Youth for Europe / YOUROPE)' (YOUROPE).

assistant: **Concept**

European democracy is presently challenged by the rise of authoritarianism, political extremism, misinformation, and the decreasing engagement of (underrepresented) youth. YOUROPE addresses the traditionally low political participation rates among, especially underrepresented, youth by tapping into their potential and aspirations through innovative approaches. YOUROPE aspires to transform European citizenship and democracy by enhancing youth involvement, creating a more inclusive democratic process, and developing policies that align with the different needs, perspectives, and ambitions of European youth, especially those who are currently underrepresented. YOUROPE is dedicated to reinvigorating European democracy by enhancing inclusivity and participation, particularly focusing on underrepresented youth and their communities. This is achieved by establishing shared democratic spaces and roadmaps through the innovative 'Community-Led Research and Action (CLRA)' methodology in combination with quantitative methods. This democratic methodology promotes a reciprocal environment of learning and action within educational institutions, recognizing their significant role in advancing European citizenship and democracy. It also ensures that strategies are grounded in evidence, sustainable, iterative, extensive in scale, and fundamentally participatory. Educational institutions are pivotal in this effort, acting as catalysts for democratic engagement. In these settings, young individuals and their communities will collaboratively develop inclusive, participatory democratic spaces and roadmaps. YOUROPE will implement this approach in 21 educational institutions, involving 630 young individuals and 6300 community members, connecting them directly with over 30 European policymakers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'eXclusions of Environmental vibrations affected by Railway Operations using metamaterials' (XeRo).

assistant: **Concept**

With the rapid development of high speed rail system, ground vibration mitigation solutions are desperately needed. As a novel vibration mitigation method, metamaterial can theoretically yield excellent performance in shielding dynamic waves in broad frequency bands. However, the application of metamaterials in railway-induced vibration mitigation is a very recent and ongoing topic. Therefore, the XeRo project aims to establish new and practical contribution towards a better understanding of the mitigation effects by metamaterials for railway-induced environmental vibrations. The experienced researcher (ER) will: 1) investigate the dominant frequencies of railway environment based on a 3D coupled train-track-soil interaction model; 2) design and develop the metamaterial based on the locally resonant mechanism; 3) characterize and optimize the metamaterial with respect to viscoelastic multi-layered soils; and 4) demonstrate the mitigation effect of the metamaterial on railway environmental vibration. Implemented at the University of Porto, and supervised by Prof Rui Calcada, the XeRo project will allow the ER to diversify her individual competence by developing skills in railway dynamics, academic dissemination and networking; student supervision; and research management and leadership. The XeRo project will also strongly benefit the ER’s inter-sectoral and interdisciplinary expertise and strengthen her international network considering a secondment will be carried out at the University of Birmingham.A two-way transfer of knowledge is guaranteed since the XeRo project combines the ER’s expertise in metamaterial design and railway vibration evaluation and the host’s expertise in the numerical modelling and dynamic analysis of train-induced ground vibrations. Therefore, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New intracellular calcium stores and apoptosis mechanisms in neurons' in the context of a Sixth Framework call.

assistant: **Objectives**

In order to maintain fidelity between a given stimulus and its own unique downstream physiological response, cells have elaborated stimulus-specific networks of intracellular signalling cascades, even within the same cell. In this context of agonist specificity, it has become clear that release of calcium from intracellular stores is a primary governing factor.Moreover, intracellular calcium stores are key and active participants in important physiological processes such apoptosis of a variety of cells. The endoplasmatic reticulum (ER) related stores and mitochondria have been long regarded as the main intracellular stores and/or calcium sinks, however recent publications demonstrated that intracellular acid lysosomal-like organelles act as novel and unique intracellular calcium stores in sea urchin eggs and pancreatic cells.More importantly, these lysosomal related compartments are involved in specific physiological responses. Here I propose a research project that aims to extend the universality of acidic calcium stores to neurons and look into its physiological implications.The specific objectives are:- to investigate if the intracellular acidic organelles can act as a calcium stores selectively recruited by extracellular stimuli in neurons; and- to explore the importance of calcium dynamics between intracellular calcium stores and disruption of lysosomal calcium homeostasis in apoptosis, an important physiological process where lysosomes have been shown to play a key role.State-of-the-art technology and innovative protocols will be used to carry out this project. The knowledge gained will lead to new insights into the signalling mechanisms of nervous system and to novel neuroprotective strategies interfering in the calcium homeostasis. Therefore, it w ill enable the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EU research programme beneficiary depositing solution in Zenodo' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A specific aim of EU’s Open Science policy is to require all publicly funded research data to be FAIR (Findable, Accessible, Interoperable, Reusable) and open by default, and it’s even a contractual requirement for Horizon Europe beneficiaries. Despite large efforts, FAIR in practice is difficult for programme beneficiaries. EU has over the past 10 years funded Zenodo, an open data repository built by CERN, to help beneficiaries comply with first open access, and then open data contractual requirements. This grant capitalizes on past investments made in Zenodo and helps EC programme beneficiaries comply with the new FAIR and open science requirements, by implementing an easy go-to solution in Zenodo for beneficiaries to make data FAIR in practice.HORIZON-ZEN’s overarching aim is to provide the EC’s programme beneficiaries with enhanced depositing services for digital research objects that are FAIR-enabling and compliant with Horizon Europe requirements, and to establish best practices for how scientific repositories can support the implementation of FAIR data principles by leading by example. This will be achieved by enhancing Zenodo with FAIR-enabling capabilities that support programme beneficiaries during the depositing of research outputs and by leveraging Zenodo’s simple and seamless user experience.


**Keywords:** FAIR, Zenodo, EOSC, Data repositories
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TOWARDS SAFE AND EFFECTIVE IMMUNOTHERAPY OF PERSISTENT LIFE-THREATENING FOOD ALLERGIES' to be submitted under Seventh Framework.

assistant: **Abstract**

The FAST project aims at the development of safe and effective treatment of food allergies. It targets persistent and severe allergy to fish and fruit. Besides persistence and severity, this choice is based on prevalence and the importance of these foods for a healthy diet. Classical allergen-specific immunotherapy (SIT) for treatment of food allergy using subcutaneous injections with food extracts has proven to be effective but too dangerous due to anaphylactic side-effects. FAST will therefore develop a safe alternative by replacing food extracts with hypo-allergenic recombinant major allergens, the active ingredients of SIT. Both severe fish and fruit allergy are caused by a single major allergen, parvalbumin for fish and lipid transfer protein for fruit. This makes development of a novel biotechnological product feasible. Two approaches will be evaluated for achieving hypoallergenicity, i.e. site-directed mutagenesis and chemical modification. The most promising hypo-allergenic versions of parvalbumin and lipid transfer protein will be produced under GMP conditions. After pre-clinical testing (toxicology testing and efficacy in mouse models), Phase I and II randomized double-blind placebo-controlled multi-center clinical trials will be performed. Two routes of administration will be evaluated, subcutaneous in case of fish and sublingual in case of fruit. The primary read-out will be the double-blind placebo-controlled food challenge. To understand the underlying immune mechanisms of subcutaneous and sublingual immunotherapy, these trials will be accompanied by in depth serological and cellular immune analyses, allowing identification of novel biomarkers for monitoring treatment efficacy. FAST will improve the quality of life of food allergic patients by providing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Predictive Position Coding', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Vision gives us enormous adaptive advantage because it allows us to see and react to events before they reach us. This predictive advantage is most obvious for an object in motion where the current trajectory predicts future location. It is equally important when the object’s motion results from the movement of our own eyes. Here our visual system uses knowledge about the upcoming motion of the eyes to predict the future location of the object. In this proposal, we will analyze both instances as two sides of a common predictive process that operates on the maps that control eye movements and spatial attention. We propose that this predictive positioning is involved not only in the guidance of eye movements and the deployment of attention to expected target locations but also for the location at which the target is perceived, including when a target is seen at a predicted location even though it is never there. This framework of a “master map” of target locations for perception as well as overt and covert orienting is a radical departure from the standard “labeled-line” model in which active neurons throughout the visual system specify the position of a target by virtue of their receptive field locations. The predictive shifts of location for moving stimuli and moving eyes, often deviating far from the retinal input, provide a powerful means for evaluating this proposal on many fronts. We will test these predictions with behavioral, fMRI and TMS techniques in healthy and neurological patients, and neurophysiological techniques in non-human primates. According to our working hypothesis, predictive position coding is a core function of the eye movement control system and its companion spatial attention system. The results of the proposed experiments will have the potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Vertical Ozone Transports in the Alps' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To improve our knowledge of the dynamics and chemistry of ozone in the Alpine region. The research project VOTALP will investigate the transport and formation of ozone and other photooxidants  in the Alps. Supplementary studies will be done in the Northern Apennines that are separated from the Southern  Alps by the Po Valley. Special emphasis will be laid on vertical transport processes, because of their great  importance in mountainous regions. Four major questions will be addressed: What is the contribution of  stratospheric intrusions to Alpine ozone concentrations ? How important is the advection of polluted air towards  the Alps, for instance during foehn, and how is the air brought down into the valleys ? How important is the  in-situ production of photooxidants in Alpine valleys ? What is the effect of exchange processes between the  valley atmosphere and the free troposphere on the ozone concentrations in the valleys and in the free troposphere  ? The project is broken down into four work packages.  Work package 1 investigates stratospheric intrusions and their contribution to tropospheric ozone concentrations  in the Alps.  Work package 2 addresses the synoptic scale advection of pollutants towards the Alpine region and the  meteorological and chemical mechanisms during foehn episodes.  In work package 3, thermally driven wind systems, their influence on photooxidants and the photochemical  production of ozone in the Alpine region are investigated.  Work package 4 deals with data preparation and handling and the synthesis of the VOTALP project. The general  strategy of VOTALP is to combine measurements and models of varying complexity. This approach is taken  to improve our knowledge of meteorology and air chemistry in the Alpine region. Therefore, VOTALP could
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Validating markets for sustainable sensing grippers in micro assembly' in the context of a Horizon 2020 call.

assistant: **Objectives**

Since Adam and Eve’s infamous apple, gripping, handling and releasing objects has been a thoroughly human activity: the hand and fingers combine muscular action with sensing, complemented by feedback from visual monitoring. Modern automation technology, e.g. in production and micro assembly lines, is now facing the challenge of manipulating of extremely small objects, with dimensions typically smaller than the width of a human hair. Existing gripping technologies are running out of steam in this range: controlled handling is either impossible by conventional processes such as suction grippers, or decreased reliability leads to low yields and productivity. Industry is urgently looking for new handling concepts and this trend is predicted to intensify after the CORONA crisis when automation will gain in importance for ensuring reliable production. The technology developed in the researcher’s original ERC Grant SWITCH2STICK turned out to be ideally suited for this purpose. Eduard Arzt’s team successfully created the fundamentals and first prototypes of gecko-inspired surfaces with switchable adhesive functions. As the technology is bioinspired it is highly energy-conserving and sustainable. Now, increased reliability during the handling process has become possible. Using novel materials for the surface structures, the research group has demonstrated in their lab the gripping of objects down to dimensions below the thickness of human hair. This function of micropatterns to handle microobjects reliably is the groundbreaking new idea which will be validated for market readiness in this proposal. Considering that the relevant industrial sector of automated micro assembly is already a multi-billion Euro market with a strong growth rate, a new solution is expected to have a larg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Large-scale subcellular ensemble dynamics in the mouse brain revealed by adaptive optics two-photon mesoscopy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Higher brain functions, such as decision-making, are associated with the coordinated activity of multiple cellular structures (e.g., cell bodies and cellular processes of neuronal and non neuronal cells) distributed over multiple brain areas. Recent technical developments enable monitoring this ensemble activity across different brain regions with high (i.e., cellular and subcellular) resolution using large field-of-view (FOV) two-photon (2P) mesoscopy. However, optical aberrations mostly due to light scattering strongly limit the application of these technologies when the imaging depth within the brain increases. To address this limitation, I will here design, develop, and validate the first adaptive optics (AO) mesoscope, combining the strength of adaptive aberration correction with the power of large FOV 2P mesoscopy. I will first benchmark this novel approach to image ensemble Ca2+ dynamics of small brain structures (e.g., processes of neuronal and non-neuronal cells) in living mice over large FOV and at increasing imaging depths. I will then focus on recording Ca2+ signals from processes of astrocytes, the main non-neuronal cell type in the brain, which play fundamental roles in brain physiology. I will study how networks of thin astrocytic structures encode behavioural information over multiple cortical regions during a decision- making task. Finally, I will apply analytical methods based on information theory and machine learning to extract emergent properties of distributed ensembles and their correlation with behaviour. In conclusion, I will combine expertise in optical engineering, neuroscience, and computation to reveal the functional dynamics of the fine cellular structures across multiple cortical areas. This project will allow extracting details about ense
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new approach to modelling turbulent planetary circulations' (CONVECT) under Seventh Framework.

assistant: **Objectives**

Observations of the Earth's atmosphere and oceans and of other planetary atmospheres have revealed highly dynamic, complex motions over a wide range of spatial and temporal scales. One of the most spectacular examples is Jupiter's atmosphere, which consists of dozens of nearly zonal counter-propagating jets of fluid along with a multitude of energetic, interacting eddies or vortices, the largest being the Great Red Spot. Somehow, in a way not well understood, these vortices not only co-exist with the counter-propagating jets but appear to play a central role in maintaining them. The key objective of this research project is to clarify how these vortices shape planetary circulations in general. This is an ambitious goal, and one which has already attracted considerable research effort worldwide. What we believe is new and worth applying in this context is a powerful numerical method, the `Contour-Advective Semi-Lagrangian' (CASL), capable of simulating a range of spatial scales simply beyond the reach of conventional numerical methods --- even on the world's largest supercomputers. But in addition, we will examine more realistic ways of forcing these flows, e.g. by implanting small-scale vortices believed to result from convective processes. Nearly without exception, previous research has considered forcing in spectral space, and usually over a narrow band of wavenumbers, to similate spectral cascades and to compare with idealised theories of turbulence. We question whether such forcing is relevant to observed planetary circulations, and we aim to contrast the two approaches. To understand specifically how jets develop in response to vortex activity, we plan to comprehensively examine idealised planetary circulations subject to both large-scale and small-scale thermal fo