RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Theology, Education, Scholastic Institution and Scholars-network: dialogues between the University of Paris and the new Universities from Central and Eastern Europe during the Late' (THESIS).

assistant: **Concept**

The THESIS project proposes a pioneering study of a coherent corpus of medieval manuscripts consisting of all the commentaries on the Sentences composed in Paris and in the new universities from Central Europe between 1350-1450. A Sentences commentary is a core component of the medieval academic curriculum, a collection of theses that scholars had to defend in the universities in order to obtain the title of master or doctor of theology; it is actually the unique equivalent of our modern PhD thesis.This investigation aims to provide new information concerning the intellectual atmosphere inside the European universities in an attempt to respond to various historical questions: How do the Sentences commentaries of this period lead to the formation of a European university identity? Who are the masters of the time? What is the importance of a Sentences commentary (the modern PhD) in the development of a individual intellectual career during the late Middle Ages? What are the relations and exchanges between the University of Paris and the new universities of Central Europe? Which are the commentaries acquired (by purchase and thus at the request of the readers) in the university libraries of this epoch and in this area of Europe? What are the cultural exchanges between secular masters, monks and friars? How do the religious orders constitute an important factor in the formation of a network for the transfer of knowledge in the universities?Research in the archives (mainly little known ones from Eastern Europe), the study of the manuscripts, the digital edition of the texts and the development of new IT tools for our field will be key components of our project, contributing to a better understanding of a hidden part of European intellectual history. Our project is built upon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The primary goal of PREVIEW is to identify the most efficient lifestyle pattern for the prevention of type-2 diabetes in a population of pre-diabetic overweight or obese individuals. The project comprises two distinct lines of evidence, both embracing European and overseas countries:1) A multicentre, clinical randomized intervention trial with a total of 2,500 pre-diabetic participants, including children and adolescents, adults and elderly.  The duration will be 3 years for the adults and elderly, and 2 years for the children and adolescents.2) Large population studies using data from all age groups.Focus in both lines of evidence will be on diet (specifically protein and glycemic index) and intensity of physical activity, as well as their interaction with the lifestyle factors, habitual stress and sleeping pattern as well as behavioural, environmental, cultural, and socioeconomic variables.PREVIEW will significantly increase our knowledge on how specific lifestyle factors can help preventing type-2 diabetes. Type-2 diabetes accounts for about 90% of all cases of diabetes, primarily caused by the worldwide obesity epidemic. Diabetes is a costly disease and according to WHO, the direct health care costs of diabetes range from 2.5% to 15% of annual national health care budgets. This worrying trend calls for action and a need for a variety of innovative approaches. PREVIEW aims to be such an innovative attempt including all necessary disciplines and stakeholders, who can contribute to developing new ways for the prevention of this wide-spread life-style related disease.The strategic impact of PREVIEW concerns the massive problems associated with the global diabesity epidemic (obesity and type-2 diabetes) and therefore includes partners from Europe (East, West, North and S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bottom-up Approaches to Machines dedicated to Bayesian Inference' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

We propose a theory and a hardware implementation of probabilistic computation inspired by biochemical cell signaling. We will study probabilistic computation following three axes: algebra, biology, and hardware. In each case, we will develop a bottom-up hierarchical approach starting from the elementary components, and study how to combine them to build more complex systems. We propose Bayesian gates operating on probability distributions on binary variables as the building blocks of our probabilistic algebra. These Bayesian gates can be seen as a generalization of logical operators in Boolean algebra. We propose to interpret elementary cell signaling pathways as biological implementation of these probabilistic gates. In turn, the key features of biochemical processes give new insights for innovative probabilistic hardware implementation. We propose to associate conventional electronics and novel stochastic nano-devices to build the required hardware elements. Combining them will lead to new artificial information processing systems, which could, in the future, outperform classical computers in tasks involving a direct interaction with the physical world. For these purposes, the BAMBI project associates research in Bayesian probability theory, molecular biology, nanophysics, computer science and electronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transition with Resilience for Evolutionary Development' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The joint Exchange programme is based on a research proposal finalized at strengthening the regional capabilities in triggering, implementing and managing Transition Management (TM) strategies towards driving “resilience-building” processes. The main aim is to combine Transition with Resilience for Evolutionary Development (TREND) of different territorial contexts. It is expected to produce a novel concept encompassing “resilience-building” processes and Transition Management strategies based on the Evolutionary Economy’s assumptions. The TREND analysis will draft from the preceding MAPS-LED project, which pointed out the territorial dimension of the innovation. As an outcome, three levels of spatial investigation are distinguished within the EU-US broader contexts: I) Internal areas, II) Leading regions, III) Regions in transition. Moreover, the diagnosis will assess the potential drivers of TM strategies including: I) territorial milieu, as successful factor assessed in preceding MAPS-LED and CLUDS projects; ii) resilience, conceived as the ability of systems –people, communities, ecosystems, nations – to generate new ways of operating new systemic relationships; iii) crisis, which hit local defined areas, conceived as opportunities, including: migration flows and economic crisis. Relying on the strong existing CLUDs research network and its International Doctorate URED, the TREND project is expected to add value to the current knowledge about regional economic diversification. By moving forward the MAPS-LED project’s outcomes concerning the Entrepreneurial Discovery Process (EDP) and the Knowledge Based Urban Regeneration (KBUR), the TREND will provide the Open Access Toolkit: a web platform accessible by community users, policy makers, investors and financial stakeh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spatial transcriptomics chips with sequencing-based microscopy' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

We propose a technology platform for low cost, high resolution spatial transcriptomics surfaces.  Spatial transcriptomics is a high cost research methodology for resolving the spatial variation of genes in a tissue by capturing mRNA transcripts on a surface containing molecular address markers. To produce these surfaces, current methods rely on either printing technology with explicit assignment of unique address ID's to spatial locations or else random scattering of molecular ID's that are then sequenced in situ using microscopy. Both of these fabrication methods are prohibitively expensive and time consuming, such that spatial transcriptomic technology is still limited to a narrow selection of low throughput research applications. Our proposed technology, the MESH CHIP represents a radically different approach to producing these surfaces. Rather than print surfaces or build sequence-address maps with in situ microscopy, our technology works by self-assembly and deduction from sequencing data alone. This means that no prior information about the identity or location of address markers on the surface is needed prior to mRNA capture and sequencing. Instead, this information is reconstructed computationally using graph theory in a post hoc fashion. By moving this information roadblock in the fabrication process to the increasingly cheap sequencing and computing stage, we greatly improve the cost performance of this technology. MESH CHIP technology would represent a qualitatively lower cost product with greater performance than the state of the art, unlocking new use cases like diagnostics and high throughput tissue processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting Meniscus Degradation in Osteoarthritis' (TARGETMENISCUS), addressing dissemination and exploitation.

assistant: **Impact**

My goal is to determine the molecular degradation of meniscus tissue, a “new” disease that leads to degenerative meniscus tears and osteoarthritis (OA). My prior research has revealed that meniscus tears are a frequent entity in OA, not typically caused by knee trauma. By focusing on the meniscus, we aim to discover novel biomarkers and new targets for pharmaceutical intervention against OA, by preventing meniscus degradation and stimulating its regeneration. In our ageing population, the burden of OA is rapidly increasing, making the first disease-modifying OA treatment an urgent matter.The proposal is based on my biobank consisting of human tissue from total knee joint replacements, knee arthroscopies, and healthy donor knees, including menisci, synovial fluid, hyaline cartilage, and blood. The two linked work packages are:WP1 Proteomics: Identification of the proteome of the meniscal matrix and biomarkers of degeneration using exploratory and targeted mass spectrometry.WP2 7T imaging: Arthroscopy patients will undergo ultra-high field 7-Tesla magnetic resonance imaging (MRI) pre-operatively and at two follow-ups. Using both high-resolution and emerging compositional imaging sequences, we will determine meniscus matrix degradation and hyaline cartilage quality changes after knee surgery. Importantly, we will link proteomics with early stage knee OA development to provide proof-of-concept that the identified biomarkers and molecular treatment targets are associated with OA.My key team members include orthopaedic surgeons, an analytical chemist with expertise in mass spectrometry, a medical physicist with expertise in MRI, and a biostatistician. We further work in international collaborations. As the principal investigator, I have an internationally recognized track rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Next Generation of Automotive Electric Motor' (2021-2027) under Horizon Europe.

assistant: **Objectives**

SciMo developed an innovative winding technology, which will revolutionize and disrupt the electric motor market. This unique technology tackles the core problems of modern electric motors that are material efficiency, power density, efficiency and cost. The SciMo motors have superior properties:• 60% higher copper density,• 90% higher cooling efficiency,• 75% higher power density,• 75% higher material efficiency,• price advantage of over 30%.So far, the winding technology has been successfully demonstrated by manufacturing over 70 motor prototypes for a variety of highly challenging applications in aerospace and motor sport where higher prices could be charged. However, the full price advantage of these motors can only be realized in a fully automated and high-volume production (>100.000 motors/year). Hence, SciMo will focus on the biggest markets, the automotive sector. The transformation to electric vehicle generates a huge market.


**Keywords:** Efficiency,Material,Winding,Series-Production,Automation,E-Mobility,Motor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Predicting the effects of gut microbiota and diet on an individual’s drug response and safety' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Precision medicine is an emerging paradigm that aims at maximizing the benefits and minimizing the harm of drugs. Realistic mechanistic models are needed to understand and limit heterogeneity in drug responses. Consequently, novel approaches are required that explicitly account for individual variations in response to environmental influences, in addition to genetic variation. The human gut microbiota metabolizes drugs and is modulated by diet, and it exhibits significant variation among individuals. However, the influence of the gut microbiota on drug failure or drug side effects is under-researched. In this study, I will combine whole-body, genome-scale molecular resolution modeling of human metabolism and human gut microbial metabolism, which represents a network of genes, proteins, and biochemical reactions, with physiological, clinically relevant modeling of drug responses. I will perform two pilot studies on human subjects to illustrate that this innovative, versatile computational modeling framework can be used to stratify patients prior to drug prescription and to optimize drug bioavailability through personalized dietary intervention. With these studies, BugTheDrug will advance mechanistic understanding of drug-microbiota-diet interactions and their contribution to individual drug responses. I will perform the first integration of cutting-edge approaches and novel insights from four distinct research areas: systems biology, quantitative systems pharmacology, microbiology, and nutrition. BugTheDrug conceptually and technologically addresses the demand for novel approaches to the study of individual variability, thereby providing breakthrough support for progress in precision medicine.


**Keywords:** Gut microbiota, nutrition, therapeutic stratification, precisi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functional characterization of Shoot Growth 1, a novel QTL-based epiallele', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Natural variation is widely used as a source of biodiversity to identify alleles controlling various traits. In the Institut Jean Pierre Bourgin (IJPB, INRA, Versailles) several groups are interested in the analysis of Arabidopsis natural variation. Classical approaches involving sets of Recombinant Inbred Lines (RIL) were developed and the genes explaining the QTLs were identified by map-based cloning and/or candidate gene approach. Interestingly, these very classical approaches led to the discovery of natural epialleles such as epiQTLs. The objective of the present project is to use my experience in the analysis of molecular mechanisms underlying naturally varying traits to study one of the very first examples of epiQTL allele isolated from crosses between natural populations of Arabidopsis. This project builds upon the work of Dr. Daniela Vlad, a former PhD student in Dr. Olivier Loudet’s lab, who identified a novel natural epiallele named SG1. The proposed project will focus on a further characterisation of this particular epiallele and of the underlying gene function.The specific aims of this project will be to:• Understand how variation at SG1 results in a dramatic effect on fitness;• Characterize the epigenetic status of the SG1 locus and its impact on the genome to gain a better understanding of the interplay between different epigenetic mechanisms leading to the regulation of plant growth.The results from this study are likely to provide important insights into the regulation of gene expression controlled by DNA methylation, and we expect they will also improve our understanding of the mechanisms by which plants integrate internal cues to adjust growth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'John Selden's Harmonic Jurisprudence. A European Interpretation of English Legal History.'.

assistant: **Innovation**

As nationalisms conspire and sectarians around the world rise against coordinated supra-national orders, Europe – the aspiration and the legal reality – is turning from being a principle of harmony to a source of cynicism. Consequently, the historical existence of a common European legal space, the actual purpose of its institutional framework, Europe's history, and its current place in the world are all being called into question. Addressing these challenges now demands front-line action by jurists and historians; it is their calling to counterweight the resurgence of blinkered narratives of national law and rediscover the “seamless web” of legal history.  Answering this calling, the proposed action will investigate the lost tradition of ‘harmonic jurisprudence’ that first conceived Europe as one of humanity’s discrete legal experiences. To do so, the action will select as its focus the unique and relatively neglected works of legal historiography written by the seventeenth-century jurist, historian, and Hebraist John Selden (1584-1654). The project will centre on Selden’s effort to balance, preserve, and harmonize the history of English law within the inclusive order of nations that his reading of medieval and modern European jurisprudence recognized. Thus, it will bring to light the cogent yet overlooked reasoning by which Selden demonstrated that no law, however discrete, can rightfully be understood if isolated from the continuum of legal experience. It is the purpose of this multidisciplinary project to understand 'why'. Developing a global synergy between the University of Michigan Law School and the School of History at the University of St Andrews, the action will document and explore Selden's layered answers in nine critical contributions to legal historiograp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Vulcanisation of footwear components by electromagnetic techniques', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Rubber is one of the most used raw materials in the footwear sector for the manufacture of soles for shoes, sheets and other items. However, it needs to be vulcanised so that its physical-chemical characteristics are appropriate for its final use. The vulcanisation is a process which needs temperature, pressure to keep the mould closed, and time, being traditionally carried out in the footwear sector as an intermittent process, which is slow and not very flexible, and therefore limits the production. The main objective of the project is to develop an alternative to this process. For this, the design and realisation of pilot scale prototype with microwave technology for the continuous vulcanisation of rubber items for footwear, was proposed. Microwave technology offers many advantages in comparison with the traditional processes: direct heating of the rubber mass and not the moulds, faster, uniform and selective, better performance, less energy consumption, better quality and reproducibility of the finished product, less heat escaping into the atmosphere, better cleaning, less implantation space, easier maintenance, electronic programming and control, automation capacity, and a more comfortable work atmosphere. Given the versatility which will be attempted to be given to the prototype constructed, on finishing the project, it will be able to be applied to different manufacturing processes in both the footwear and other sectors where vulcanised rubber is needed. The applications of the rubber could be: vulcanisation for soles for footwear. vulcanisation of sheets, vulcanisation of latex foam for innersoles, finishings and coverings of sheets etc.