RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mechanisms of Mismatch repair inactivation and identification of genes suppressing mutations'.

assistant: **Concept**

The fidelity of DNA replication, and therefore the stability of the genome, relies on the DNA Mismatch repair (MMR) pathway, which recognizes DNA replication errors and promotes repair by an excision and re-synthesis mechanism. Mutations that inactivate MMR are associated to Lynch Syndrome, an early-onset cancer disorder characterized by accumulation of mutations at repetitive sequences or microsatellite instability (MSI). Interestingly, a significant number of tumors with MSI have not been correlated with MMR defects, suggesting that additional factors may influence MMR proficiency or DNA replication fidelityThe current proposal aims to investigate alternative molecular mechanisms that result in MMR inactivation and to identify unrecognized genes that are essential for suppression of mutations. We will characterize a subset of Msh6 dominant mutations that abolishes MMR function by inactivating the partially redundant Msh2-Msh3 pathway. Furthermore, we will carry out a genetic screen to identify dominant mutations on the MMR-related genes: MSH3, MLH2 and MLH3 that result in MMR inactivation. Finally, we will carry out a genome-wide screen in budding yeast, to identify mutants that results in increased mutation rates. The human homologs of the identified yeast genes will be further characterized in human cell lines by knock-down experiments and in vivo mutator assays. This proposal is directed to achieve a better understanding of mechanisms preventing accumulation of mutations and will provide relevant information for diagnosis of cancer susceptibility syndromes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A general law describing the diffusion of membrane proteins in vivo based on single molecule tracking of membrane proteins in Escherichia coli' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ultimate goal of cell biology is to understand how proteins function in real cells and to understand their regulatory mechanisms. To achieve this goal one needs to analyze molecules in their cellular environment and not under idealized test tube conditions. A major difference between in vivo and in vitro conditions is the crowdedness (and associated molecular complexity) of the cytoplasm and biological membranes. As a consequence diffusion in this environment is significantly slower.  To make biology more quantitative, we should measure the key parameters such as reaction rates and diffusion coefficients in vivo. Here, I propose an experimental set-up to measure the diffusion of membrane proteins in live bacterial cells. The main objective of this project is to establish a relationship between the diffusion coefficient and number of trans-membrane helices (radius in the membrane) of membrane proteins. The mobility of fluorescently labeled proteins will be probed at the single molecule level in the membranes of a model prokaryotic organism – Escherichia coli. Single molecule tracking of membrane proteins systematically increasing in size (radius in the membrane) will be implemented to obtain a general model of protein diffusion in the membranes. Assigning actual numbers to the parameters of a cell will provide a quantitative context for systems biology efforts and sharpen our understanding of how a cell works. By training-through-research, the fellowship will allow me to learn new techniques (single molecule tracking, programming) and how to build/align microscope set-ups. This will help me transform from a microscope user to a microscope constructor and vastly increase my potential as a cell biologist. In the international and interdisciplinary environment of the ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Providing Fire Fighters with Technology for Excellent Work Safety' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of project ProFiTex is to support fire fighters in their perilous work with a system that supplies mission-relevant information without overwhelming the fire fighter. The design approach will be user-centered with tests starting at an early point in the project to gain maximum user acceptance. Professional fire fighters will be involved from the beginning of the project to ensure, that the system will be tailored to their needs. Project ProFiTex will continue the work of the successful EU-funded project wearIT@work.   The ProFiTex system comprises electronic devices like an infrared camera, localisation sensors and a human-computer interface device integrated into the fire fighters jacket.  Since wireless communication is difficult over long distances and through several walls of a building, an innovative method to transmit information will be applied. A security rope carried by fire fighters during a mission shall be equipped with data transmission capabilities. This allows information to be sent outside to the command post and back to the fire fighter.  By monitoring several parameters of the fire fighters condition like his movement pattern and stance, problems can be detected immediately. The fire fighter himself is supplied with the possibility to navigate even in smoky environments thanks to the infrared camera and the positioning system implemented into his equipment. Localized information (e.g. “door”, “victim”) can be fed into the system using the garment-integrated human-computer interface device.   Information will be displayed to the fire fighters, their group leaders and the commander outside the building. The amount and type of information supplid will be carefully chosen, considering the physical danger and psychic stress  fire fighters are oppose
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TransEpiSeed: The role of mRNA methylation in control of seed germination' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Seed germination is a unique phase of the plant life cycle. Its correct coordination is crucial for seedling establishment, and germination is, therefore, key for crop survival and yield. The improvement of seed germination will be highly important for modernized precision agriculture.Seeds accumulate a substantial amount of translationally inert mRNA during maturation. These mRNAs have a strikingly long half-life allowing seeds of certain plant species survive up to thousands of years. Upon water-uptake, these mRNAs are translationally activated in support of seed germination. The function of mRNAs stored in dry seeds has been a mystery for decades. My recent work demonstrated that these stored mRNAs are associated with ribosomes and that they get translated during early seed germination. Therefore, an understanding of the regulatory mechanisms that govern the storage of these mRNAs in dry seeds, and their eventual translation upon germination will reveal tremendous insight into seed germination.A multitude of mechanisms might affect mRNA translation. Common to them is that they must involve sequence-specific recognition of a signal within the transcript, such as an mRNA modification. N6-methyladenosine (m6A), the most widespread internal mRNA modification, has been shown to have important role on mRNA stability or translation efficiency involving recruitment of specialized m6A-binding proteins, in plants referred to as EVOLUTIONARILY CONSERVED C-TERMINUS (ECT) proteins. TransEpiSeed aims to study the relevance of m6A for translational control during seed germination by investigation of m6A dynamics and the function of ECT proteins. Combining my knowledge on the translational regulation of seed germination with expertise on m6A of the host lab provides a strong base to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European group for future advances in science and technology for nuclear engineering thermal hydraulics' under Fifth Framework.

assistant: **Concept**

EUROFASTNET means European project for Future Advances in Sciences and Technologyfor Nuclear Engineering Thermal-Hydraulics. Starting by an exhaustive review ofthe industrial needs for the next ten years and after a state of the art in therelevant fields, new avenues of research in physical modelling, numericaltechniques, experimental investigations, and advanced instrumentation will bedefined. The point of view of the industry, the utilities, the R&D institutes, thesafety institutes, and research laboratories of Universities will be associated.This Concerted Action should result in a common understanding on what are the keyproblems and which R&D work should be initiated to solve them. It should give riseto an enhanced European co-operation for present and future development work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainable End-of-life routes for single-use monodose packaging for oily products' (E-OILE).

assistant: **Innovation**

The packaging industry is responsible of around 60% of post-consumer SUP  wastes and most likely to become litter in natural environments. While factors such as fast consumption patterns, safety concerns or  compact size, hinder effective packaging waste recycling, the need for safe alternative biodegradable solutions is mandatory. E-OILÉ will address safe and sustainable biodegradable packaging solutions close to the market by: a) demonstrating at TRL 7 cost effective production of biodegradable materials based on novel biopolyesters and polysaccharides, engineered  to enhance barrier and mechanical performance,  to replace Polyolefin materials (PP and PE) and PET in monodose packaging solutions ecodesigned as biodegradable monomaterial structures or combination with coating technologies and following the SSbD framework ; b) implementing a circular business model, food and cosmetic products, through 4 Uses Cases (UC): Olive oil- UC1; oily sauces- UC2; Body oil- UC3 and Oil serum- UC4); c) validating the packaging performance, shelf life, safety and sustainability along the whole supply chain (from material producers to end users) and demonstrating complete biodegradability following relevant standards and in environmentally relevant conditions and, therefore, sustainable End-of-Life (EoL) pathways for the new packaging solutions in combination with the use of Artificial Intelligence (AI) and advanced modelling mechanisms for digitally-assisted accurate prediction of degradation processes. The consortium is integrated by 15 partners of the whole supply chain: large companies, SMEs and Start-up as materials producers (2) to the end-users of food and cosmetic sectors (2) through the packaging producers (3). Partnership will also involve supporting RTOs and other non-profi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Children as Agents of Cultural Evolution' to be submitted under Horizon Europe.

assistant: **Abstract**

Cultural evolutionary theory is quickly gaining traction as a unifying framework for the social sciences. However, research into culture acquisition paints a picture of children as vessels for inheriting evolved culture from adults, rather than cultural producers in their own right. ChACE aims to overturn this long-established orthodoxy by taking child and adolescent peer cultures as a focal point. Neglected by cultural evolutionary theorists, peer cultures are incredibly well conserved across generations despite threats to social transmission inexistent in adult cultures, challenging our understanding of how cultures are maintained and changed across generations. By intensively studying childrens peer cultures, ChACE thus stands to discover novel causal mechanisms for cultural evolution. ChACE specifically advances two ground-breaking hypotheses built upon firm theoretical and empirical foundations in folklore, cultural evolution, human life history, and cognitive development: (1) Peer cultures evidence distinct cultural evolutionary mechanisms from adult cultures; (2) Knowledge produced as part of peer cultures helps communities adapt to social and ecological change. ChACE will develop a robust and transferable methodology to jumpstart the study of peer cultures. Reflecting best-practice workflows for causal analysis, ChACE will first build ethnographically informed agent-based models to derive testable and falsifiable predictions. These will be empirically evaluated via experiments, observations, surveys, and interviews with children and adolescents aged 4-16 years, and their caregivers, at four globally representative field sites undergoing rapid culture change: the Likouala (Republic of the Congo), the Omo Valley (Ethiopia), Toledo (Belize), and County Durham (U.K.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Functional DNA nanomaterials'.

assistant: **Concept**

Solid phase DNA synthesis is certainly one of the most influential developments of the last century. Together with the understanding of DNA structure and function, not only biology and molecular genetics have advanced significantly, but also new emerging fields such as bio-nanotechnology would not have evolved. The term 'DNA architectonics' is probably most descriptive for the current directions the field of DNA synthesis is taking, where DNA becomes more and more a construction material and intelligent glue while not downgrading its importance in the life sciences.The research proposed here will evaluate novel functional DNA nanomaterials and will significantly advance the field by combining DNA nano-technology with chemically modified nucleosides, incorporating designer molecules to add specific programmed function and apply these systems to make ground breaking advances in electronics, photovoltaics and medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THE SOCIAL MEANING OF IMAGES: ADVERTISING POSTERS IN THE FIRST HALF OF THE 20TH CENTURY IN PARIS' (SOCIALMAPONPARIS).

assistant: **Concept**

With this fellowship proposal I intend to explore the cultural context of the city of Paris in the first half of the 20th century, through the analysis of a specific cultural object: the advertising poster. My research will look at these posters as “social events” that create new historical identities through a communicative and symbolic efficacy. In this way I analyze these images as a real source of documentation of social practices, and as main social actors in the communicative interactions. My work will necessarily be interdisciplinary, merging together the textual meaning sciences and a narrative approach with the history of graphic arts and social-interaction-oriented methodologies. My research will also concern the relation between art and advertising during the birth of a modern city. In general I can state that, from their beginnings in the 19th century with Manet’s posters, the relation between the poster and Paris is a primal binomial that engendered the future evolution of advertisting arts, with influences still visible today. This is true not only in Paris but also in many other European cities. This is the reason why, by studying the cultural identity of Paris, we will also be studying an important aspect of a more general European identity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bamboo Innovative Fiber for Technical Textile and Environment Conservation' in the context of a Seventh Framework call.

assistant: **Objectives**

Fiber-reinforced composites have been in use, in particular for aeronautical applications, for the past 40 years, mostly thanks to their high specific mechanical properties providing high strength and stiffness. Nevertheless, in light of the growing environmental awareness, classic fibers, such as carbon fibers or glass fibers, suffer several drawbacks among which the fact that they are based on non renewable resources, the high amounts of energy required to produce them and their recycling at the end of their lifetime which is problematic.Thus, over the last decade, natural fibers have received increasing interest as a potential replacement for classic synthetic fibers, especially for polymer matrix composites, thanks to their bio-based character, good specific mechanical properties and renewable supply.Bamboo fibers i.e. cellulose fibers extracted from the pulp of bamboo plants have excellent natural mechanical properties. With an average density of bamboo fiber of 0,9, bamboo specific mechanical properties even exceed those of glass fibers.Bamboo fibers offer new perspectives for producing ‘greener composites’ in the sense that they constitute a renewable resource and the processing of the fibers is environmentally friendly. However, existing bamboo fibers tend to be short and randomly oriented, which means the resulting composite mechanical properties are relatively low. It is well-known that fibers provide the highest strength and stiffness when they are continuous and aligned in the direction of applied load. There is currently no process capable of spinning bamboo fibers into continuous strands. Further developments are therefore needed.In the BIFTTEC project, BAMBOO FIBERS TECHNOLOGY, a French SME which has developed a novel industrial extraction process to extr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Diffrential expression of Nostoc PCC7120 psbC gene family' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

In the last decade, the full genome sequence of a number of cyanobacteria became available. While these efforts have rewarded us with a lot of information, they also open the question: What do all those genes do?" This is especially true in the case of multi gene families were multiple genes code for similar but not identical proteins. The genome of one of those, Nostoc PCC 7120 (a.k.a. Anabaena PCC 7120), an filamentous heterocystous cyanobacteria was published in 2001, and found to contain 5 psbA genes, coding for two versions of D1, the main PSII protein, and 4 psbC genes coding (by sequence analysis) for three different versions of the CP43 protein, believed to be involved in energy transfer from the light harvesting complex to the reaction centre.The different D1s have been found to express in response to UV light or light intensity. But to date there is no information as to if, when, and where the different genes psbC genes are expressed. A homologous gene, isiA has been found to be expressed under iron stress conditions and to create a ring shaped `light harvesting complex-like¿ structure around PSI. We offer to use a combination of bioinformatics, molecular, biochemical, biophysical and physiological techniques to study the role of the different genes in the psbC family of Nostoc 7120. We will look at expression level in RNA and protein level, at photosynthetic potential, and at the exitonic structure of the light harvesting systems of Nostoc PCC 7120 cells grown under different conditions. We will also compare the above between vegetative cells and heterocysts to test the possibility that an alternative psbC is involved in energy transfer to PSI under diazotrophic conditions."