RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Contrast Agents for Protontherapy PET Range Monitoring'.

assistant: **Innovation**

In radiation therapy, proton therapy has a more favourable dose distribution than conventional radiotherapy with photons and electrons. However, in order to fully exploit this dosimetric advantage, it would be required to verify the range of protons in the patient with mm accuracy. The most used strategy for in-vivo range verification in protontherapy relies on positron emission tomography (PET) activation. As they progress through the patient, proton beams undergo nuclear reactions than can produce radioactive isotopes, some of which are positron-emitters. This induced radiactivity can be detected in commercial or dedicated PET scanners and used to deduce the delivered dose distribution in the patient.While a promising technique, two main challenges have so far limited its clinical implementation: first, the proton interaction cross sections of the elements making up the body (C, O, N, H) are relatively low, which causes the positron dissintegration counts detected by the PET scanners to be about 1 or 2 orders of magnitude lower than the usual numbers in nuclear medicine. And second, the spatial and temporal distributions of PET emitters follow a very complex relation with the dose depositions which complicate the range verification process.The CAPPERAM project aims at solving these two problems by using Zn-based contrast agents in the patient during irradiation. Zn has a very high cross section for proton interaction peaking at very low proton energies, which produces a very high concentration of PET emitters near the end of the proton range.The action, comprising both computational simulations and phantom experiments, will take place in Sedecal Molecular Imaging, a company dedicated to the fabrication of high-precision PET devices, with a 6-month secondment at the gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evolution of Developmental Gene Pathways' (EVODEVOPATHS).

assistant: **Innovation**

The staggering diversity of the living world is a testament to the amount of variation available to the agency of natural selection. While it has been assumed that variation is entirely uniform and unbiased, recent work has challenged this notion. Evolutionary developmental biology seeks to understand the biases on variation imposed by developmental processes and their distinction from selective constraints. Metazoan development is best described by developmental gene pathways which are composed of transcription factors, signaling molecules, and terminal differentiation genes. A systematic comparison of such pathways across species would reveal the patterns of conservation and divergence; however this has not yet been achieved. In the EvoDevoPaths project we will develop a new approach to unravel pathways using both single-cell and tissue-specific transcriptomics. Our aim is to elucidate the evolution of developmental gene pathways using intricate embryology in the nematode phylum, a single-cell transcriptomic method we have developed, and sophisticated computational approaches for pathway comparisons. We will ask how variation is distributed across the specification and differentiation modules of a pathway using the nematode endoderm pathway as a model system. We further propose that the evolutionary change in the tissue specification pathways of early cell lineages is constrained by the properties of cell specification pathways. To test this hypothesis we will, for the first time, determine early developmental cell lineages from single cell transcriptomic data. Finally, we will attempt to unify the molecular signatures of conserved stages in disparate phyla under a framework in which they can be systematically compared. This research collectively represents the first
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MOBile NETwork for people's location in natural and man-made disasters' (MOBNET), addressing dissemination and exploitation.

assistant: **Impact**

Unmanned vehicles (UVs) now play an increasing role in Public Protection and Disaster Relief (PPDR) missions such as border surveillance, cropping monitoring or local law enforcement. However, fast location of isolated people in the case of natural or man-made disasters still continues to be a crucial and arduous task.MOBNET will design a Search and Rescue (SAR) system for the location of isolated victims in the case of natural or man-made disasters such as earthquakes, hurricanes or large snow storms. It will also help first responder services to find fugitives or smugglers hidden within buildings. To that end, the use of European Global Navigation Satellite (EGNSS) systems (both Galileo early services and EGNOS) and Digital Cellular Technologies (DCT) will play the key role in these situations in which it is difficult, dangerous or even impossible to access the affected areas. The EGNSS and DCT technologies will be tightly synchronised to provide accurate positioning. However, this demanding synchronisation exceeds the current capabilities of most GNSS and cellular equipment. In order to achieve the required performance, novel EGNSS and DCT methods will be applied. Furthermore, an effective and reliable communication link between Unmanned Aerial Vehicles (UAVs) and the ground station will be designed. This datalink will ensure uninterrupted command and control communication among devices and the integrity of communication signals. Thus, the UAVs will always operate as intended.  Research will be driven by the end-user and industrial partners to ensure that it addresses the needs of the PPDR services. The potential for a fast and reliable SAR system will be illustrated by a prototype that will work at long distances. The developed SAR system will take advantage of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Selectivity database'.

assistant: **Concept**

This proposal is a Concerted Action with thirteen partners to define the specifications and conditions for use and maintenance of a selectivity database.Selectivity data are used in mesh assessments by assessment biologists. Estimates of fleet selectivity are necessary to calculate fishing mortality rate at age. The objective of this feasibility study was to define the specifications and conditions for creation, use and maintenance of a database containing fishing gear selectivity information. The project was split in sixteen tasks, among which three plenary discussion meetings, an inventory of needs with potential users, an inventory of available computer facilities and software, an inventory of available selectivity data, and cost estimates for creating and implementing the database as well as filling it with data. A total of twenty experts participated. Database options considered were: an on-line catalogue only; an on-line catalogue with an exchange format; an on-line catalogue with a user data screening program; a central store of ASCII files with on-line catalogue (web site) and extract bunch of data; a hosted database with an on-line catalogue (web site) and extract subset of data. The various options were scored against a set of criteria involving: quality, availability, security, ease of management, relevance, ease of use, data extensibility, function extensibility, effort for data provider, and turnaround time after which database type hosted database with an on-line catalogue (web site) and extract sub-set of data seemed to offer the best value for money, although the costs for software development, data handling and future management are the highest of all the options compared. The group also produced draft lists of variables at experiment and at haul level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Technical viability of a novel device for automated high-volume screening of teratogens based on simultaneous quantitative computer-assisted microscopical evaluation of clonal cell cycle progression and differentiation state'.

assistant: **Concept**

The developmental toxicity studies required by the regulatory authorities for registration of new pharmaceuticals and agrochemicals require a large number of animals and considerable effort from skilled technical personnel. The cost of testing a single chemical substance are approximately 250kECU, a factor which severely limits the number of novel agents and process derived by-products which can be evaluated. As a consequence the large number of novel compounds produced in research laboratories and those intermediates of step-wise procedures in the chemical industry, will never be tested by these in vivo procedures. In vitro methods provide an alterative strategy for assessment of developmental toxicity however the most promising methods are time consuming, involve animal use and require skilled personnel. Development of a simple, reliable and rapid screening system is required to facilitate the pharmaceutical and agro-chemical industries in evaluating embryotoxic potential in the large number of existing substances and the new materials which are added to the list each year. EU Directive 86/609 dictates that animals must not be used for testing if a validated, non-animal test is available and the EU BIOTECH Programme has as a goal the development of such assays for the in-vitro detection of teratogens. Previously, members of this consortium have been contracted under the BIOTECH programme to identify in-vitro endpoints for the development of such tests (BIO2CT930471). As the most significant initial steps in the emergence of developmental toxicity is inhibition of cell division coupled with a premature differentiation, coincident evaluation of these endpoints was found to reliably discriminate known teratogens from non-teratogens in structurally related agents using si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In Vitro Derivation of Beta Cells by Ectopic Expression of Pancreatic Transcription Factors' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Type 1 diabetes mellitus affects an estimated 0,5% of the world population. Autoimmune rejection results in destruction of the insulin producing beta cells of the pancreas, leading to both acute and long term complications. Daily injection of exogenous insulin allows long term managment of the condition, but does not avoid long term complications. Reconstitution of the beta cell compartment by pancreas or cadaveric islet transplantation is heavily restricted by shortage of donor material and immune rejection issues. Any progress in obtaining large number of transplantable insulin producing cells would be a major advance towards a cure for the disease. The general objective of this proposal is to establish a method to transdifferentiate adult human cells to the beta cell phenotype by direct reprogramming by forced expression of an optimized set of pancreas specific transcription factors. The underlying experimental rationale is that sequential or combinatorial ectopic expression of transcription factors can induce recipient cells to establish a beta cell regulatory state. The experimental methodology is to clone a set of native or modified transcription factors known to be involved in pancreatic development into viral vectors and use them to transdiferentiate adult human cell types in conditions known to favor beta cell differentiation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanisms in Toxicity' under Fifth Framework.

assistant: **Concept**

While the objective of modern toxicology is still protection of life against external harmful factors, the focus of research in this field has gradually evolved toward a mechanic oriented science. Also it has become apparent during recent years that food contaminants are a relevant health risk for the consumer. Another novel aspect is the reviewed interest that industry has in the identification of new targets based on mechanistic studies to assess reliably adverse of drugs and to develop new therapeutic principles. The proposed conference is focused on the most recent development in our understanding of the molecular mechanisms leading directly to cell dysfunction or causing stress responses and consequent organ failure. The identification of new sensitive molecular targets will help to bridge the gap between in vitro studies and the in vivo implications of toxic and pathological processes and eventually unveil the relationship between exposure to toxic agents and food contaminant with slowly developing degenerative diseases. The interactions between the central nervous system and the immune system will be addressed in several lectures. The conference plan is articulated in six separate sessions dealing with models of neurodegeneration and organ failure, and with the molecular determinants in the execution of apoptosis, which may be particularly relevant to slow neurodegenerative conditions and immunologically-mediated disorders.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00136-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Oscillations in Basal Ganglia Disorders' in the context of a Horizon 2020 call.

assistant: **Objectives**

Basal ganglia is a brain structure, whose dysfunction is tightly tied with a variety of severe neurological diseases, including the widespread Parkinson’s and more rare Huntington’s diseases. Despite many efforts, current treatments for Parkinson's disease have many serious drawbacks and for Huntington’s disease barely exist.Basal ganglia play an important role in motor control and motor learning, which are both faulty in the diseases. A complete understanding of basal ganglia is still lacking though a better understanding of it is required to understand the diseases better. A distinctive feature of basal ganglia is oscillatory activity, that correlates with movement execution in different ways for different frequencies. The oscillations patterns are known to change in pathological conditions. E.g., an increase in beta-band oscillations power starts to occur in Parkinson's disease. It appears that direct high frequency stimulation of basal ganglia output structures removes some of the most important Parkinson's and Huntington's diseases symptoms. The mechanism of action of this deep brain stimulation technique is not well understood, but it is believed to act by interfering with anomalous oscillations.""How exactly basal ganglia oscillations are related to the diseases?"" is an important long-standing question, that requires a system-level approach to be answered. The project aims at the development of a detailed basal ganglia system-level computational model, constrained by experimental data and coupled to a movement system. Use of analytical and numerical approaches and close interaction with experimental neuroscientists during the model development will make it provide a coherent explanation of many basal ganglia-related behaviors in healthy and pathological brains a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Collaborative REsearch on ACute Traumatic brain Injury in intensiVe care medicine in Europe'.

assistant: **Concept**

Traumatic brain injury (TBI) is among the leading causes of death and disability and the main cause of death among the under-45s. Most patients with moderate to severe TBI are admitted to intensive care units (ICUs)The “PROSAFE” ICU network was recently established in 6 European countries through EU funding (PHEA 2007331), and has continued to collect high-quality data beyond the grant duration. In 2011, 225 ICUs had joined PROSAFE, recruiting a total of 73,163 patients, 2,694 of whom were admitted for TBI. Hence  the network can expect to enrol 7-9,000 moderate to severe TBI patients in 4 years. The PROSAFE consortium has already focused attention on TBI and has just started collecting additional information on this condition in order to develop a prognostic model to identify centres of excellence in TBI managementAims of proposal are to consolidate the existing network in order to better describe the epidemiology of moderate-severe TBI in 7 countries (Greece has now joined the consortium); build a prognostic model based on short- and long-term outcome measures; identify most effective clinical interventions for optimally treating TBI patients, and recognize the determinants of optimal vs suboptimal performanceAll TBI-CDEs endorsed by InTBIR will be collected, along with other items needed to develop a sensible prognostic model, permitting the consortium to join forces with international collaborative initiatives in the fieldAvailing of the coordinating institute’s biobank and consolidated expertise in biochemical and genetic biomarkers, the aim is to identify prognostic markers and underlying genetic factors influencing response to treatment and final outcomeThe PROSAFE consortium is thus in a position to guarantee superior quality data collection in 7 countries and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FILMEU_RIT - Research | Innovation | Transformation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

FILMEU_RIT brings together four European Higher Education Institutions: UL - Lusófona University from Lisbon, Portugal; SZFE – University of Theatre and Film Arts, from Budapest, Hungary; LUCA School of Arts from Brussels, Belgium; and IADT - Dún Laoghaire Institute of Art Design and Technology, from Dublin, Ireland. Together, these institutions collaborate around the common objective of jointly promoting high-level research, innovation and educational activities in the multidisciplinary field of Film and Media Arts and, through this collaboration, consolidate the central role of Europe as a world leader in the creative fields.FILMEU_RIT will increase the Alliance’s competitiveness and reinforce its ability to develop activities that span all the areas of the knowledge square: education, research, innovation, and service to society, while helping the creative sector to affirm its potential for innovation and resilience in a post COVID-19 context.FILMEU_RIT will develop a common R&I agenda for artistic research supported by common resources and joint structures that will increase talent attraction and the impact of the research developed amidst the alliance.  Such impact seeks to promote greater engagement of society and business with art and creativity in order to increase European competitiveness and its artistic R&I profile.FILMEU_RIT’s main objective is the capacitation, in Research and Innovation terms, of the individual HEIs that integrate the Alliance via the joint design of strategies and action plans that ensure the transformation of the future European University into an Institution that puts Research and Innovation in the fields of Film and Media Arts at the centre of its activities and operates as a highly valuable critical cultural intermediary.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Management of bulking sludge in waste water treatment based on rapid bacterial population identification using automated probe hybridization technique' in the context of a Fourth Framework call.

assistant: **Objectives**

Bulking sludge in biological waste water treatment plants (WWTPs) causes environmental pollution, higher discharge costs and can lead to the temporary closure of production units. Fast and specific detection methods need to be developed for the identification of microorganisms causing bulking sludge. 16S rRNA sequences, specific DNA probes and automated methods will be developed and used for a quantitative and specific detection of these microorganisms in activated sludge. WWTP managment is improved based on retrieved correlations between WWTP process conditions and growth of specific filamentous microorganisms causing bulking sludge. Partners that are sought for this research programme include industrial partners with WWTPs (pulp and paper industry), partners with expertise in automated methods for sample processing and microorganism detection using techniques in molecular biology.