RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Invention of Cultural Diplomacy: cooperation and transnational competition in European and transatlantic international relations 1870-1940' (INVCULTURALDIPLO).

assistant: **Concept**

Cultural diplomacy has gained extraordinary significance in European international relations since the end of the nineteenth century as countries faced challenges in their Empire and as military force on foreign soil became increasingly contested. This project examines the making of this new aspect of foreign policy from the late nineteenth century until the beginning of the Second World War, with a focus on three case studies: Britain, France and Germany. The US will also be analysed as a battled ground for the cultural diplomacies of these western European countries. Employing an interdisciplinary approach – drawing on diplomatic and political history, cultural studies, transnationalism and textual analysis, the project will examine a broad range of private and diplomatic documents, as well as published pamphlets and media sources. The project’s first objective is to evaluate why European countries turned to foreign cultural policies as a new element of their diplomacy. Secondly it aims to reassess the chronology of the rise of cultural diplomacy, which the historiography conventionally sets to the 1920s (when cultural diplomatic bureaux opened in European foreign offices). Thirdly the project aims to renew our understanding of the policy making practices in this domain. These objectives will be met by transcending bi-national approaches that dominate the historiography of cultural diplomacy to assess the influence of entangled national competitions and asymmetric ways in which France, Germany and Britain conceptualised the significance of culture for their European and transatlantic diplomacies. Building upon theories of new diplomatic history that have stressed the significance of non-state actors, this research also goes beyond Foreign Office-centred approaches to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring molecular determinants of charged disordered protein interactions, phase separation and function from the test-tube to the cell' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Biological molecular recognition is centred around the structure-function paradigm, involving interfacial complementary shapes and non-covalent forces. Intrinsically disordered proteins (IDPs), constituting up to 40% of the proteome, evade the structure-function paradigm, owing to their lack of persistent structure. Despite some IDPs forming folded complexes, numerous IDPs form disordered complexes stabilized by multivalent interactions. An extreme example is the recently discovered disordered high-affinity complex formed by two highly charged IDPs, the nucleosome binding linker histone (H1) and its nuclear chaperone prothymosin-alpha (ProTa), both key regulators of chromatin-structure and -function. IDPs are also often implicated in liquid-liquid phase separation (LLPS) driven assemblies that facilitate numerous biochemical interactions. The specificity question in IDPs becomes particularly pertinent for such charge driven disordered interactions and associated LLPS processes considering the great abundance of such highly charged disordered stretches in our proteome. Specific physiological function of most IDP interactions and associated LLPS processes imply an important role of specificity, albeit encoded differently from folded proteins. Only a multidisciplinary study spanning several complexity regimes, which is currently lacking, can uncover such altered specificity. I hypothesize that physiologically, ProTa/H1 interaction plays out in LLPS-driven heterochromatin assemblies leading to transcriptional regulation. I will probe ProTa/H1 interactions and phase behaviour with a set of systematically designed variants in incrementally complex milieu, from the test-tube to the cell, to reveal how the sequence dictates interactions and phase behaviour in-vitro and attribut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scaling EUROpean citizen driven transferable and transformative digital integrated health and social care' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SEURO targets Europe’s 50 million multimorbid patients to proactively self-manage and offset the EU’s annual €700 billion cost of chronic disease management.  SEURO aims to evaluate key factors to prepare organisations, localities and regions across the EU to scale, sustain and transfer the people-centred, digital integrated care platform ProACT (developed and successfully tested at proof of concept level under Horizon 2020, PHC-25-2015, Grant No. 689996). Research will aim to advance 3 novel implementation support tools. These consist of a transferability self-assessment tool (ProTransfer) to assess preparedness for solution transfer; a behavioural change framework (ProBCF) to optimise a solution to people’s needs; and an artificial intelligence (AI) prediction model (ProInsight) to assess the impact of a solution on health system performance. Effective Implementation Hybrid Trials (720 older adults in total, with associated care/support actors) will be carried out with ProACT within health services (Ireland, Belgium Sweden to measure platform effectiveness), with embedded process evaluations to understand the process for successful ‘real world’ implementation. Participants will have at least two of the following: cardiovascular disease (excluding Stroke), a respiratory condition and diabetes. Commercial potential will be validated during the project supported by an exploratory trial (Italy) to evaluate the impact of SEURO in facilitating a procurement process for healthcare service providers aiming to implement ProACT.  SEURO engages a multidisciplinary EU consortium of 4 public and 8 private organisations (including one of the world's leading ICT companies, the largest home care provider and 2 EU service provider and technology networks). Partners have a successful c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A model system to study host genome dynamics mediated by integration of non-retroviral RNA virus' (NRVINTEGRATIONMODEL).

assistant: **Concept**

Genome dynamics is known to be affected by abiotic and biotic factors which enrich the diversity among cells and individuals of the same species. Stress induced by pathogens has been demonstrated to impact host genome stability, but little is known about the effect of non-retroviral RNA viruses (NRVs). NRVs carry a RNA genome and no DNA stage is involved during its infection cycle. Therefore, integration of NRVs' sequences into its host genome is not expected. Despite that, integration of a NRV segment into the host genome has been reported in mammals, plants, insects, fungi and bacteria and was suggested to raise new host phenotypes. Additionally, integration of a host segment within a defective NRV's genome has also been reported demonstrating reciprocal sequence exchange between NRV and its host.  Although it has been demonstrated that NRV retrotransposition occurs, the nature of that NRV-mediated host divergence is not clear. Here we propose to further investigate the mechanisms and implications of host-genome plasticity due to NRV integration by building a molecular NRV integration model based on the Lymphocytic Choriomeningitis Virus (LCMV), which has been found integrated within its respective hosts genome, the mouse (Mus musculus) as well as the human. This LCMV-based system is design to carry an integration-induced selective marker, which is assumed to enable identification of cells carrying a DNA version of LCMV-derived sequences in vitro and in vivo. Through combining this experimental system with data analysis, it is likely that we'll be able to initiate, select and track such LCMV-derived integration events. The aforementioned system will serve as a model to determine LCMV's integration frequency, mechanisms, as well as possible implications such as somatic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fungal resistance to antifungals is promoted by cell heterogeneity'.

assistant: **Innovation**

The number of people who die from fungal infections is estimated to be equivalent to or greater than the numbers that die from either tuberculosis or malaria. There are only 3 classes of antifungal drugs available to treat these invasive diseases and resistance against these drugs is increasing. In this study I will investigate how antifungal resistance is impacted by cell heterogeneity in the pathogenic fungus Aspergillus fumigatus. The main hypothesis that I will test is that fungal cell heterogeneity provides subpopulations of cells with greater fitness to resist antifungal treatment. I will determine: (1) which features of three distinct fungal cell types contribute to cell heterogeneity; (2) which cell types and subpopulations of these cells show highest resistance or survival against antifungals; and (3) the roles of septal plugging and cell ploidy in the mechanistic basis of fungal cell heterogeneity. Cutting edge technologies that will be used in this study will include: (1) flow cytometry and fluorescence activated cell sorting (FACS) to identify and select cell subpopulations to test their antifungal resistance, (2) automated, high throughput, high content live cell imaging to analyse the resistance of single cells to antifungals, (3) advanced live-cell imaging techniques including GFP photoactivation and fluorescence recovery after photobleaching (FRAP) to identify septal pore plugging; and (4) laser microdissection to further analyse septal pore plugging. With these advanced techniques I will study the mechanistic basis of fungal resistance mediated by cell heterogeneity. My results will ultimately show how fungal cell heterogeneity impacts fitness against antifungal drugs and they will be the starting point for designing novel antifungal therapies that redu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inequality and Integration' (IneQint) under Horizon Europe.

assistant: **Objectives**

Socioeconomic inequality has become increasingly intertwined with immigrant status in many Western European societies. One important question is whether and how socioeconomic disadvantages among immigrant parents hamper the integration of their children. This project focuses on inequality and spatial segregation, and how they affect the children of immigrants in terms of their wellbeing and structural, social and cultural integration. We ask how integration in different dimensions comes to be, analyzing the internal workings of schools, including grading, ability grouping, and social relations among classmates. The complex nature of the questions we address requires outstanding and up-to-date data: one of the major contributions of this project is to collect such data. This will be achieved via a longitudinal survey conducted among 5000 pupils in 100 representative Swedish comprehensive schools, coupled with parent, register and digital data. The project also offers excellent opportunities to assess changes in inequality and integration over the last 15 years through comparisons with pre-existing data. Sweden provides a particularly interesting case due to its high immigration (particularly from the Middle East and Africa’s horn), increasing income inequality, growing ethnic and socioeconomic school segregation, and rapidly decreasing support for immigration. The data will make it possible to study changes in inter-ethnic social relations, attitudes, values, religiosity and subjective wellbeing over time – all within the context of the structural opportunities set by inequality and segregation. The study also obtains information (from teachers, headmasters and registers) on school organization, resources, and climate, producing a comprehensive picture of the school sett
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SECurity of Railways against Electromagnetic aTtacks' under Seventh Framework.

assistant: **Concept**

SECRET addresses the protection of railway infrastructure against EM attacks. Railway infrastructure is an attractive target for EM attacks, because of its familiarity and ease of access, with extended economic and security consequences.Today, the European rail network is evolving to harmonize the management system. This is reflected by new integrated technologies, adequate procedures and centralization of command centres. The new technologies facilitate the implementation of a harmonized system and improve the network competitiveness. However, they are also highly vulnerable to EM attacks (HPM and EMP). Railway actors fear this growing EM vulnerability and have no knowledge on the extent and severity of consequences.The risk of EM attacks is also increasing due to the higher use of interoperable systems (command/control, information systems). The harmonization of the European railway network results in a harmonized EM vulnerability. Thus, a device to generate EM attacks will have the same impact anywhere in Europe, facilitating the implementation of simultaneous EM attacks.Meanwhile, with the proliferation of wireless systems, access to radiated emission equipment is radically democratized, which facilitates the manufacture of EM interference transmitters able to disturb the technologies used for management of the railway network.Objectives of SECRET are to:-identify the vulnerability points at different levels (from the electronic to the systemic vision)-identify EM attack scenarios and risk assessment (service degradation, potential accidents, economic impacts…)- identify public equipment which can be used to generate EM attacks-develop protection rules to strengthen the infrastructure (at electronic, architecture and systemic levels)-develop EM attack detection devi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Receptor Recruitment as an Organizational Principle for Self-Assembling Matter' under Horizon Europe.

assistant: **Concept**

Receptor recruitment occurs in biology as a response to binding, for example, by virus particles to a cell membrane. The interactions that underlie the binding process are typically multivalent in nature, in other words, multiple interactions of the same motif occur simultaneously to provide a collective, cooperative effect. This project aims to employ recruitment as a design criterium for self-assembling building blocks into well-defined architectures. Intrinsically weak and dynamic interactions are essential in achieving self-assembly and recruitment. Exquisite control over stoichiometry and structure of the assemblies is achieved by harnessing ground-breaking developments in the understanding of these multivalent interactions. Follow-up fixation processes will be developed to transfer the molecular organization onto stable building blocks and materials. Functional, e.g., fluorescent, groups will be implemented into the systems to provide insight into recruitment and self-assembly processes. These breakthrough insights will be used tackle challenges with the identification, sensing and isolation of biological particles. High-throughput methods will provide technology to screen multiple virus–glycan combinations with the aim of providing ‘fingerprints’ of viruses based on their binding behaviour. Platforms with nanoscale dimensions and molecular functionalities will be prepared, which will be used for single-particle sensing and particle isolation of, for example, virus particles and extracellular vesicles. As such, this proposal takes inspiration from nature, by borrowing recruitment as a concept to build self-assembled materials, and to contribute to a better understanding of living systems using new detection and isolation tools, with application prospects for biome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ecological genetics of Bryozoa-Myxozoa host-parasite interactions' (BRYOZOA) targeting Seventh Framework.

assistant: **Abstract**

Understanding the clonal and population genetic structure of the freshwater bryozoan Fredericella sultana is essential for understanding the epidemiology and management of the myxozoan parasite Tetracapsuloides bryosalmonae that causes the Proliferative Kidney Disease (PKD) in wild and farmed salmonids. Common, widespread and susceptible F. sultana clones can serve as a persistent parasite reservoir, supplying disease epidemics in fish, yet, at present, no information of the clonal structure of F. sultana populations exists. To predict the impact of environmental change on spread of PKD in fish, it would be essential to resolve questions regarding geographic distribution of susceptible and resistant F. sultana genotypes, and their potential response to environmental change. At present such information is not available due to lack of neutral genetic markers for F. sultana. This 15 month fellowship proposal will (i) develop the required nuclear genetic markers that will allow high resolution genetic studies of the clonal and population genetic structure of F. sultana populations, and (ii) use these markers in the first genetic surveys of F. sultana populations that are either known to carry the disease or known to be healthy, based on earlier ecological surveys. Results of the study will be highly beneficial for preventive and predictive applications to manage PKD in salmonids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Resilient CLIMATE Financing and Investment Taskforces' in the context of a Horizon Europe call.

assistant: **Objectives**

Urgent accelerated action is required to adapt to unavoidable and ongoing climate change. Climate-resilient investments must be substantially scaled up. Public budgets will not be able to address the adaptation financing challenge alone, financing from the private sector will also be necessary. CLIMATEFIT contributes to bridging the resilience financing gap by providing critical insight and building the capacities of Public Authorities (PAs) to attract and orchestrate various public and private funding & financing sources, and of Financing and Investment Entities (FIEs) to discover and access resilient investment opportunities.CLIMATEFIT will experiment on a mix of 20 territories in Southern, Eastern and Northwestern Europe in their transformational pathways towards climate resilience. The journey will start by taking stock of funding & financing barriers and enablers gathered in the Financing Landscape taxonomy. CLIMATEFIT will create an ingenious Manual for leveraging finance to, 1) co-design 20 innovative investment strategies allowing to identify sources of funding 2) develop 10 credible and scalable investment plans to help better negotiate and articulate financing streams and define investment concepts, and 3) pilot 4 bankable, tailored investment cases. CLIMATEFIT will build a Pathway for FIEs to accelerate finance, test refined methods to reward climate-resilient investment and apply smart adaptation funding and financing solutions. It will establish Local Resilience Taskforces (LRTs) composed of PAs and FIEs that propose a catalytic and systemic approach to resilience financing. Led by WCF, the high-level consortium will build capacity, co-create solutions with PAs and FIEs, and inform EU adaptation and sustainable finance policies. Finally, CLIMATEFIT aims to