RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spatio-temporal coupling between transcription and translation dynamics during development' (LightRNA2Prot).

assistant: **Innovation**

During development, precise control of gene expression allows the reproducible establishment of patterns, leading to the adoption of cellular identities at the right time and place. What are the mechanisms behind such precision? To date, this question has been primarily examined from the focal point of transcription. However, precision in mRNA production is functionally relevant only if it leads to precision in protein expression. While the linear correlation between the levels of a given mRNA and the amount of protein it encodes has been assumed for the last six decades within the central dogma of molecular biology, many examples challenge this view. The control of translation, particularly in distinct subcellular compartments where mRNA are targeted, may lie at the heart of this mRNA to protein disconnect. LightRNA2Prot aims to unravel the mechanisms underlying the lack of correlation between mRNA and proteins levels to elucidate the sources of reproducible cell fate decisions during development. Importantly, it considers both the layers of regulation constituted by transcription and translation respectively, as well as their potential coupling. We will use quantitative imaging methods that simultaneously monitor mRNA, nascent peptides, and protein in Drosophila living embryos, combined with genetic/optogenetic manipulations to dissect the mechanisms at play. LightRNA2Prot focuses on two key questions: 1-How do the translation dynamics of key localized developmental transcripts modulate precise patterning? 2-How are (co)-transcriptional nuclear events coordinated with translational control in space and time? Combined with mathematical modeling and phenotypic characterization, our quantitative approaches will provide a dynamic multiscale view of gene expression control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy HarveStorers for Powering the Internet of Things' (HARVESTORE) targeting Horizon 2020.

assistant: **Abstract**

A breakthrough in micro-energy harvesting and storage technologies is required to cover the increasing demand of autonomous wireless sensor nodes (WSN) for the future Internet of Things (IoT), which is considered one of the five technologies that will change the world by connecting 27 billion devices and generating €2 trillion market by 2025. The HARVESTORE project aims to power these IoT nodes from ubiquitous heat and light sources by using nano-enabled micro-energy systems with a footprint below 1cm3. Using disruptive concepts from the emerging Nanoionics and Iontronics disciplines, which deal with the complex interplay between electrons and ions in the nanoscale, a radically new family of all-solid state micro-energy sources able to harvest and store energy at the same time will be developed. This new devices will be called “μ-harvestorers” (μHS). In order to enable this science-to-technology breakthrough, our nano-enabled μ-HSs will be integrated in silicon technology. This will allow reaching the highly dense features and scalability required for a real miniaturization and massive deployment that will show their viability as a new technological paradigm of embedded energy. The HARVESTORE project addresses this challenging objective by building an interdisciplinary research consortium that includes consolidated and emergent leading researchers in modelling, microfabrication, materials science and energy together with high-tech pioneer SMEs with unique capabilities to develop and deploy IoT nodes for real applications. Moreover, the structure and communication strategy have been designed to make HARVESTORE a lighthouse project for boosting this novel micro-energy paradigm and building around an innovation ecosystem founded on emerging Nanoionics and Iontronics applie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Modelling Emerging Transport Solutions for Urban Mobility'.

assistant: **Objectives**

Disruptive technologies, such as MaaS and CAVs, are bringing radical changes in urban mobility. The goal of MOMENTUM is to develop a set of new data analysis methods, transport models and planning support tools able to capture the impact of new transport options on urban mobility, in order to support cities in the task of designing the right policy mix to exploit the full potential of emerging mobility solutions. The specific objectives of the project are:1. Identify a set of plausible future scenarios for the next decade to be taken into account for mobility planning in European cities, considering the introduction of disruptive technologies such as CAVs.2. Characterise emerging activity-travel patterns, by profiting from the increasing availability of high-resolution spatio-temporal data collected from personal mobile devices and digital sensors. 3. Develop data-driven predictive models of the adoption and use of new mobility concepts and transport solutions, in particular MaaS and shared mobility, and their interaction with public transport.4. Provide transport simulation and planning support tools able to cope with the new challenges faced by transport planning, by enhancing existing state-of-the-art tools with the new data analysis methods and travel demand models developed by the project.5. Demonstrate the potential of the newly developed methods and tools by testing the impact of a variety of policies and innovative transport services in different European cities with heterogeneous sizes and characteristics, namely Madrid, Thessaloniki, Leuven, and Regensburg, and evaluating the contribution of the proposed measures to the strategic policy goals of each city.6. Provide guidelines for the practical use of the methods, tools and lessons learnt delivered by the proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Constraints and Forces for p-Block Element Mediated Bond Activation and Catalysis'.

assistant: **Concept**

Enabling p-block element species for challenging bond activations is crucial for advancing sustainable alternatives to transition metal catalysis. Even more transformative are concepts that guide reactivity in a generalizable manner and for cross-disciplinary impact. While sub-valent species or Frustrated Lewis pairs served as foundational paradigms for p-block-mediated bond activation in recent decades, the structural constraint strategy is emerging as a groundbreaking third approach. However, its fragmented and uncoordinated exploration has limited its broader potential and interdisciplinarity.CONSTRAINOPHORES will consolidate this concept by defining constrainophores (""constrain"" + -φόρος, meaning ""carrier of"")—molecular p-block systems with intrinsic structural constraints—and pre-constrainophores, flexible centers activated by external forces such as electric fields, light, and mechanical stimuli. Fundamentally, the project will establish a rigorous theoretical framework for molecular deformation with intuitive descriptors to connect constraint effects from molecular to material scales. On the applied front, it will achieve breakthroughs such as phosphorus-mediated C–C cross-coupling, unprecedented terminal oxido chemistry, or the first functional models for semiconductor active sites. Harnessing electric fields will enable cleavage of non-activated C–H bonds, while photochemistry will add an overlooked dimension to the field. Embedding (pre-)constrainophores into polymeric chains will create next-generation materials capable of deformation-induced p-block transformations under mechanical stress.CONSTRAINOPHORES addresses key limitations of abundant yet underutilized elements, reshapes design paradigms for main-group reactivity and catalysis, and couples previo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Directed evolution of enantioselective biocatalysts' under Fifth Framework.

assistant: **Concept**

The European Pharmacopoeia mentions around 1600 different synthetic pharmaceuticals of which around 40% display chirality's. Despite the fact that the wrong" stereoisomer only contributes to unwanted side effects, the majority of choral drugs are administered as a race mate. As a result of more stringent safety precautions there is now a strong need for efficient and clean enantioselective catalysts. Lipases are very promising candidates, however, most of them have evolved under natural conditions different from the industrial applications. This proposal aims to develop novel tools for directed evolution of enzymes in the laboratory and to provide novel lipase variants as enantioselective biocatalysts for important pythons. Both phage display and periplasmic display will be explored as selection techniques. The model proteins are Bacillus subtitles and Pseudomonas aerations lipase, whose 3D structures have recently been solved."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MXI: MATRIX CHARGING INTERFACE INTEGRATING EVS INTO A SMART ENERGY SYSTEM' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Easelink designs, develops and markets a revolutionary automated charging solution integrating electric vehicles (EVs) into a smart energy system: Matrix Charging (MC). We are the first true interface technology that connects all relevant players along the automotive and energy value chain (OEMs, Tier1s, infrastructure suppliers + providers, EV drivers). Easelink was founded in 2016, with its headquarters in Graz, Austria and additional offices in Munich, Germany and China, thereby being located in two European automotive hotspots (Tier 1s in Graz, OEMs in Munich) and the largest EV market. We have been fast-growing from the get-go and boast a current headcount of 38 people. Our revenue model is based on licensing our technology with additional direct sales generated by own efforts. Our mission is to set the global standard for automated charging. We want to be the go-to provider for a frequent and broadly rolledout automated charging solution for EVs and thereby solve the last hindrances that currently hold back e-mobility. Our vision is a world where EVs are automatically connected to the grid everywhere and at any time. A car charging at the next public pad while grocery shopping. A car being connected in the office garage during a long workday, making use of renewable energy produced. We envision a world, where EVs are integrated into the grid and energy is used when needed, as needed. Cars become driving energy storages, feeding back into the grid at high demand times. Matrix Charging is a combination of the MC connector (MCC) installed under vehicles and the MC pad (MCP) placed on roads or portable (plug&play): The Matrix Charging System comprising a vehicle unit (MCC) and an infrastructure unit (MCP). Each MCC is compatible with each MCP, supporting charging wher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Minimum interoperability specification for key escrow systems' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The research project aims to introduce a minimum specification that supports interoperability for key escrow systems. This specification addresses key management issues that are critical to key escrow systems. The objective is to look into issues covering key generation, key distribution, key storage and key recovery both on users' and authorities' requests. The research explores all the characteristics of the various key escrow systems that are in use or under investigation and specifies a minimum set of them which will enable the communication among these schemes. The specification will be available to companies interested in offering interoperable key escrow components and it can serve as a basis for criteria for new key escrow schemes explored. Training content (objective, benefit and expected impact) Support is sought under this programme to fund Mr. Rantos as a full-time research (Ph.D.) student to carry out the proposed project. Mr. Rantos will be able to take advantage of the existing training facilities offered to all research students, including a regular Information Security research seminar and day to day access to a number of senior academics. The training will therefore be at the research level, of potential value both to industry and academia.  Links with industry / industrial relevance (22) The Ph.D. project will involve regular interactions with the existing ASPeCT project. This will follow naturally from the current employment of Mr. Rantos within the ASPeCT programme, and from the involvement in ASPeCT of Professor Chris Mitchell, Mr. Rantos's Ph.D. supervisor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'pre-Normative Research on Hydrogen Releases Assessment' in the context of a Horizon Europe call.

assistant: **Objectives**

How much hydrogen (H2) is released from the value chain? To answer the question is very challenging since insufficient and, when available, no standardized data can be found in the literature. However, it is essential to cover this knowledge gap to perform any credible and scientifically validated research regarding the H2 value chain impact on the climate change. The literature is full of studies investigating and calculating the risk of H2 leakages in case of failures, accidents, and emergencies. But significant knowledge gaps exist about the amount of anthropogenic H2 (in the atmosphere) from the H2 value chain. The research community needs to address this by improving the capability to quantify small and large releases, delivering validated methodologies and techniques for measuring or calculating them. A universally accepted and open-access inventory is needed as soon as possible. Likewise, an open access and comprehensible tool that is easy to be used is also asked by the stakeholders to better quantify the leaks from the whole in H2 value chain while the momentum is fast gathering to upscale H2 energy applications. The NHyRA project is specifically designed to address these urgent needs. The project will deliver a ""H2 releases"" inventory to serve as a reference for the scientific and industrial community. New or adequately adapted experimental, theoretical, and simulation methodologies will be validated to perform laboratory or in-field measurements to achieve the ambitious goal. Experimental tests will also be performed on the most critical elements of the H2 value chains by the partners of the Consortium. A complete picture of the H2 releases' scenarios in the middle (2030) and long (2050) term will be developed to enable decision-makers to identify and prior
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Business Opportunities in Biotech: Innovation Associate to leverage cell-free synthetic biology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The main objective of BOB is to hire and integrate a highly-committed candidate to build up an innovation strategy at c-LEcta to valorize its unique technology platform by developing an innovation project according to the company strategy to become a food ingredient producer. The envisaged innovation will help to solve the industrial problem of natural product synthesis, which is today hampered by yield limits, inefficiencies in chemical synthesis, or side-effects. The functional potential of numerous natural products can only be fully exploited if the commercial production at low cost is possible. Synthetic biology is expected to achieve a break-through for increased or cheaper production. c-LEcta has conceptualized a unique technology platform, already demonstrated the concept’s feasibility, and is targeting new molecules for further growth. However, the innovation team currently lacks of a candidate that comprises excellent technology knowledge in industrial biotechnology and/or food science and innovation management or business administration skills for assessing market values at an early development stage. The German job market is currently marked by a lack of expert personnel, and c-LEcta is experiencing difficulties in receiving high-quality responses to such a position, as it is not visible enough to job-seekers. This will be overcome by a targeted international publication of the vacancy on EURAXESS and beyond. After acquisition of a suitable candidate according to the defined profile, the specific objectives of BOB are: 1) to train the Associate according to a dedicated initiation and advanced training plan (according to the specific needs of the candidate); 2) to identify and assess new target products; and 3) to turn this assessment into an innovation idea a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding DSB repair from pathway choice to long term effects and their consequences.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

DNA safekeeping is one of the most important functions of the cell. Since DNA damage occurs in the context of chromatin, it affects both the DNA itself, but also the epigenetic landscape. While the repair mechanism of the DNA has been extensively studied, questions abound regarding the restoration of the epigenetic landscape, and the long-term effects that damage leaves in the region. In this proposal I aim to address these questions using modified DSBs repair sensors from different pathways such as “homologous recombination” and “non-homologous end joining” to map the repair process. Our method will allow us to investigate the influence of the natural epigenetic landscape on pathway choice, the dynamic process of repair and the restoration of the region. Moreover, we will investigate whether certain repair processes leave long- lasting effects at the site of damage or even “epigenetic scars”. The advantage of our method is that it allows us to map each sensor repair time-line in an unbiased and high throughput manner over extended periods of time, even once the damage is already repaired. These questions are especially important for our understanding of ageing, and age-related diseases that are driven by DNA damage. Last, we will test the long-lasting effects of past damage in two different contexts: animal models of neurodegeneration, where DNA damage accumulates, and in the efficiency of reprograming to produce healthy induced pluripotent stem cells (IPCs).


**Keywords:** Double Strand Break repair, epigenetic signaling, DNA damage response, Ageing, DNA damage sensor