RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Flavour of New Physics'.

assistant: **Innovation**

The Standard Model (SM) of electroweak and strong interactions, supplemented by neutrino masses, provides an extremely successful description of all available experimental data in elementary particle physics. However, the basic origin of electroweak and flavour symmetry breaking remains largely unknown, as well as the mechanism stabilizing the electroweak scale. In the coming years, direct searches at LHC will shed light on electroweak symmetry breaking and probe new physics models with new particles up to the TeV scale. At the same time, an impressive amount of data in the flavour sector will be collected at dedicated experiments such as LHCb, Super B-factories, MEG, NA62 and others. This upcoming experimental information sets the stage for the present project, which aims at: i) providing the theoretical tools needed to fully exploit experimental data in the flavour sector, implementing state-of-the art calculations in a consistent framework within the SM or in any New Physics (NP) model discovered by (or not ruled out by) direct searches; ii) determining the flavour structure of the effective Lagrangian that describes energies up to the TeV scale and above, combining direct searches with flavour data; iii) searching for a fundamental mechanism of flavour symmetry breaking that can justify the flavour structure of TeV-scale physics. This fundamental mechanism should address both the SM flavour puzzle, i.e. the origin of masses and mixings of quarks and leptons, and the NP flavour puzzle, i.e. the mechanism protecting TeV-scale NP from causing large deviations from the SM predictions in the flavour observables we have measured so far. The main support requested to the ERC is for hiring six experienced researchers, the rest of the funds are for optimizing the effectivene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of ecology as a modulator of sexual conflict in the wild: an experimental approach with Drosophila melanogaster' (SexWarEcol) under Horizon 2020.

assistant: **Objectives**

Sexual conflict is essential to understand phenotypic evolution in promiscuous species. Yet we know very little about how it operates in the wild and how ecology may help explain the overwhelming variation in sexual traits showcased in nature. I propose an ambitious multi-disciplinary approach combining phenotypic-level measurements with transcriptomic and proteomic tools to study the ecological factors that underlie variation in sexual conflict in Drosophila melanogaster, at a global ecological scale. This is a powerful system because: a) it has a global distribution that spans marked ecological variation, b) it exhibits intense sexual conflict including well studied pre- and post-copulatory traits, c) its sexual conflict traits have been shown to harm females and decrease population viability, d) it affords the use of state-of-the-art molecular techniques and e) despite being a model organism in sexual selection and sexual conflict studies, we know very little about the role of ecology. I will study 1) how temperature, population density, sex ratio and habitat characteristics modulate sexual conflict across different levels of sexual selection (i.e. pre-copulatory vs. post-copulatory) and genetic conflict (i.e. intra-locus vs. inter-locus sexual conflict), 2) the role of phenotypic plasticity and local adaptation in shaping sexual conflict responses to temperature, 3) how this may impact population viability, and 4) the physiological and genetic mechanisms underlying variation in sexual conflict. Given the novelty and reach of the questions addressed this action represents an important advance in our understanding of how sexual conflict evolves and operates in nature, as well as the consequences in terms of potential eco-evolutionary feedback on population viability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms of earliest hematopoietic cell fate control' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

How blood cells and ultimately hematopoietic stem cells (HSCs) arise from uncommitted cells during development is only vaguely understood. Especially the initial formation of the first blood precursors in lateral mesoderm has been difficult to dissect. Investigating these early mechanisms of blood cell fate determination with genetic model systems provides a vital starting point for therapeutic drug discovery and the targeted manipulation of iPS cells to treat hematologic diseases. The goal of the proposed research project is to elucidate the mechanisms that drive uncommitted embryonic cells into a hematopoietic cell fate by using the vertebrate zebrafish (Danio rerio). To visualize, isolate, and fate-map the earliest stages of hematopoietic cell formation, the proposed work applies transgenic zebrafish reporters under control of the newly isolated draculin gene promoter/enhancer. draculin is the earliest marker for the emergence of hematopoietic cells from lateral mesoderm during embryo development. The transgenic labeling with draculin will be harnessed for progenitor culture assays to uncover the earliest hematopoietic cell fate potential of uncommitted lateral mesoderm. These experiments will be complemented with in vivo fate mapping using Tamoxifen-controlled Cre/lox methods. The proposed study will also apply novel zebrafish microinjection approaches to test and identify transcription factor combinations that enforce blood cell fates and HSC formation. The preliminary results revealed a combination of transcription factors that ectopically induces a hematopoietic gene program in the embryo. Altogether, this work will break new ground in our understanding of the earliest blood-forming mechanisms, and provide new insight into how cells can be experimentally guided t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Eco-management accounting as a tool of environmental management.' (1994-1998).

assistant: **Concept**

To explore how environmental costs and benefits can be systematically incorporated into the measurement of corporate economic and environmental performance.OBJECTIVES: To explore how environmental costs and benefits can be systematically incorporated into the measurement of corporate economic and environmental performance. DESCRIPTION: An accounting framework (the Ecomac Framework) which indicates how environmental costs and benefits can be systematically incorporated into the measurement of economic and environmental performance is developed and tested. The Ecomac Framework applies to both capital budgeting and the optimisation of business operations. The project explores the central hypothesis that a systematic linking of management accounting with environmental management improves the efficiency and cost-effectiveness of environmental measures. The interface needed to establish an effective system for the monitoring of environmental costs and benefits is investigated for a broad range of cases. A survey among 20 companies in each of the countries involved (United Kingdom, Germany, Italy and the Netherlands) shows the range of problems connected with the linkage of management accounting with environmental management; it also indicates their relative importance. The survey results are then used in the selection of the in-depth case studies (at least four in each country involved). These case studies are both exploratory, dealing with specific environmental problems, their management-accounting implications and are illustrative in sofar that they involve best practice in the way management accounting serves to monitor the environmental costs and benefits of existing operations and under-pin possible environmental measures. The dissemination of the results are emphasized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative Imaging Insights (I3): Development of MR-compatible Bioreactors for Tissue Engineered Heart Valves' (I3) under Horizon Europe.

assistant: **Objectives**

Given the escalating global burden of valvular heart disease and the pressing need for living heart valve replacements, I decided to focus my research on this healthcare challenge by acquiring new skills through advanced training and international interdisciplinary collaborations. My proposal I3 combines the design and application of a novel bioreactor for assessing tissue engineered heart valves (TEHVs) by highly advanced magnetic resonance imaging (MRI) to kickstart the innovation cycle in in-vitro experiments. Especially young patients with valvular heart disease will profit from TEHVs as they suffer from current heart valve replacements lacking the ability to self-repair and growth as well requiring the life-long intake of anticoagulants.Leveraging the high-dimensional, non-invasive analysis potential of MRI, my I3 proposal establishes new innovative tools for TEHV research to enable new insights in the resulting hemodynamics downstream of TEHVs, close the optimization loop in-vitro using patient-specific boundary conditions and reduce the need for ethically and monetary challenging animal experiments.Building on my expertise on advanced MRI, I will acquire new skills to develop a novel MRI-compatible bioreactor in the project. Enabling in-vitro experiments with high precision and repeatability, the imaged flow field in the bioreactor allows me to select and optimize a TEHV for specific hemodynamics of patients. In-vivo MRI-enabled feedback of the resulting hemodynamics offers further diagnosis. Furthermore, in-vitro and in-vivo measurements offer important information for optimization of TEHVs for patient-specific treatments.I will use the knowledge and skills gained from this inter-sectoral and inter-disciplinary project for my next career steps (incl. submission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SensPD: Early Diagnosis of Autism' (SensPD).

assistant: **Concept**

About 1 in 45 babies born today will be diagnosed later in life with Autism Spectrum Disorder (ASD). But final diagnosis will come only at age four, too late for early interventions that would allow them to markedly improve their level of functionality, enabling them to acquire needed social skills to be integrated in society. When interventions are applied before the age of two the outcome is an over 90% success rate of social integration, as compared to after the age of five, where the success rate drops below 11%.People with ASD in all its forms have Sensory Processing (SP) issues, SensPD monitors SP performance by measuring the Oto-Acoustic Emissions (OAE). This procedure is objective, short, non-invasive and can be performed hours after birth. SensPD aims to include this procedure in the standard battery of tests performed on every new-born, enabling early interventions, and realizing the cost savings associated with this improved functionality.  During Phase I, SensPD will complete the technological and economic feasibility of the device and the service. SensPD will conduct three small scale clinical studies, each with 30 diagnosed subjects between the ages of two to five and 30 controls. The readings will be compared with results of the current diagnoses, thus establishing the technological feasibility. SensPD’s economic viability will be tested from the perspective of using the device as an add-on to an already existing OAE measuring device (and not as a stand-alone device). We will negotiate with an OAE device company as a strategic partner and complete the approval of the patent in Europe and USA.In Phase II, SensPD will conduct widened multi-site clinical studies (~250 subjects per site), will start the regulatory process and the establishment of a cloud glob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel smart materials for biomedical application' (Bio-smart) under Seventh Framework.

assistant: **Objectives**

Over the last decade, considerable progress has been achieved in the treatment of both traumatic skin injury, such as severe burns, or the treatment of chronic soft tissue injury, such as chronic ulcers, by the use of tissue engineering scaffolds within which either natural, or stem cell based tissue regeneration can take place. One of the problems of using scaffolds in hospital is bacterial infection, which tends to start at a focal point, and spread across the wound bed and by the time this is obvious enough to see, the infection is well-progressed and difficult to eradicate with either antibiotics, or silver or iodine dressings.This proposal seeks to develop a novel material, smart cryogels, capable of responding to specific “signalling molecules” released either by bacteria or as a product of the immune response; to be used as wound dressings, and as tissue engineering scaffolds. The strategy proposed in the proposal is to secure the antimicrobial agent inside the polymer matrix controlling its release until it is needed. This allows targeting of the areas affected by infection, with antimicrobial agents, thus performing micro-point treatment. The fast specific response also allows release of the antimicrobial agent at the first sign of bacterial colonisation, providing earlier treatment, preventing infection and bacterial spreading, thus providing better treatment. The ability to treat infection at an earlier stage will significantly improve the healing process, providing better treatment and reduction of cost.The potential benefits of the project are very high, as the novel smart macroporous materials which will be developed have clear clinical and commercial potential as delivery materials for diverse applications in medicine, such as biomaterials, sensing/diagno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MIND: A Unique and Ground-breaking System for Home Intelligence that Builds Functional, Assistive, Dynamic and Comforting Infrastructure for a Better and more Efficient Living.' (MIND) targeting Horizon 2020.

assistant: **Abstract**

Today we are facing many societal and environmental challenges (e.g. globalization, ageing population, intricate working schedules, transportation, climate change, etc.). Much of the impact from these events could be addressed and alleviated by modernizing our habits and living environments to make them more functional and efficient. Today, the technological solutions available to control, monitor and automate essential home functions are contained in the fields of home-automation and smart-homes. However, both sectors still offer plenty room for improvement since they often give raise to compatibility issues and demand direct management from the user. Thus, available technologies are far from complying with the user’s needs and also fail to achieve their main goal: simplifying our living routine, making it more efficient and assist us when needed. In response, we have created MIND, an ICT-based integrated solution able to intelligently modulate, respond, assist and learn to control most of the activities that take place in our homes. Its main objective is to ensure that home intelligence becomes easy to use, attentive and assistive. MIND has been designed following the principles of “calm technologies” (non-intrusive approach), remaining invisible to users both from an aesthetic point of view and from the user experience side. On the other hand, a suite of advanced algorithms implements a self-learning mechanism that learns & adapts to the users’ habits. The objective of the Feasibility Study is to identify & prepare ourselves to address all the technical, commercial and financial aspects influencing the project. Altogether, MIND will help to enhance everyone’s quality of life while optimizing the use of energetic resources. Our goal is to offer users efficiency & sust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Far-infrared Lasers Assembled using Silicon Heterostructures' in the context of a Horizon 2020 call.

assistant: **Objectives**

The THz part of the electromagnetic spectrum (0.3-10 THz) is currently exploited in commercial security screening systems (weapon detection beneath clothes), medical diagnostics tools (skin and breast cancer, burns, and in ophthalmology) and production-line monitoring (non-destructive test in the pharmaceutical industry). Existing sources of THz radiation are still too large and expensive to be a massively deployed in all of the existing and proposed applications, which include large bandwidth wireless communications and the extension of security screening to far-infrared spectroscopic identification of chemicals and explosives up to 10 THz. A lower production cost, a higher level of integration with control electronics, and a broader range of emitted wavelength are all desirable to expand the application of THz radiation.FLASH, will develop a room-temperature THz laser integrated on Si using CMOS technology-compatible processes and materials. The laser, of quantum cascade type, will be assembled using newly developed conduction-band germanium-rich heterostructures. It will leverage on the non-polar nature of silicon and germanium crystal lattices to potentially enabling room temperature operation, and will emit over 1 mW of power in the 1-10 THz range. In perspective, the development of the SiGe heterostructure platform will pave the way towards the new field of nonlinear silicon photonics based on band-structure engineering. The consortium includes EU leaders in silicon chip manufacturing, Si/SiGe/Ge epitaxial material growth, laser and band structure modelling, quantum cascade laser design and terahertz/infrared spectroscopy. The proposed device can provide a step-change in compactness, reduced cost, and functionality of source performance, thus enabling large scale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modulation of AMPA receptor properties by auxiliary subunits' to be submitted under Seventh Framework.

assistant: **Abstract**

AMPA-type glutamate receptors (AMPARs) mediate most fast excitatory synaptic transmission in the brain. The regulation of certain AMPARs (calcium-permeable; CP-AMPARs) is relevant in synaptic plasticity, neuronal development and certain neurological diseases. AMPARs are regulated by transmembrane AMPA regulatory proteins (γ-2, -3, -4, -8; TARPs), which affect the trafficking and also important biophysical properties of AMPARs. Among them, we have recently demonstrated that TARPs increase single-channel conductance and attenuate block by intracellular polyamines of CP-AMPARs (Soto et al., 2007). However, the mechanisms involved in those changes are yet to be determined. On the other hand, new AMPARs auxiliary subunits have been recently discovered, such as γ-5, γ-7 or CNIHs raising interesting questions regarding the role of these proteins in AMPARs function. For example, how do TARPs modify the block of AMPARs by polyamines? How do the new auxiliary subunits affect some biophysical properties of AMPARs? Do TARPs or CNIHs modulate AMPARs in periferic nervous system (motorneurons or Schwann cells)? Therefore, the aim of the proposed research project is to further our understanding of the roles played by AMPARs auxiliary subunits (TARPs and CNIHs). We will address the following issues: 1) Using patch-clamp techniques we will investigate AMPARs modulation by auxiliary subunits and the molecular mechanisms involved in that modulation. 2) With the patch-clamp technique in either expression systems or neuronal cultures, we will study AMPARs auxiliary subunits focusing on the new recently discovered ones. We will take advantage of pharmacological and molecular tools (site-directed mutagenesis and siRNA) combined with the patch-clamp records. 3) The role of auxiliary subunits wi