RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Early recognition of intracranial aneurysms to PRevent aneurYSMal subarachnoid hemorrhage' (PRYSM).

assistant: **Concept**

Intracranial aneurysms usually go undetected until rupture occurs leading to aneurysmal subarachnoid hemorrhage (ASAH), a type of stroke with devastating effects. Early detection and preventive treatment of aneurysms fall short as we do not know who is it at risk and why, as we have insufficient insight in the contribution and interplay of genetic, environmental and intermediate phenotypic risk factors. Given the rarity of the disease, there is a paucity of large and rich cohorts to study risk factors separately with sufficient power. To add to the problem, my preliminary findings suggest disease heterogeneity with subgroup specific risk factors for aneurysms. The sex-related heterogeneity is most eminent in the disease with 2/3 of patients being women. I aim to advance disease understanding to allow early recognition of intracranial aneurysms to prevent ASAH.I have established a new conceptual approach that integrates genetic and environmental risk factors with imaging markers as intermediate phenotypes for genetic factors. With data reduction and machine-learning approaches I will for the first time address disease heterogeneity and aneurysm risk with adequate power. I will develop and validate a tool to automatically detect new imaging markers predicting aneurysm development applying feature-learning models. Next I will elucidate the genetic basis underlying differential imaging risk patterns (imaging genetic factors). I will apply a new hypothesis-free strategy to detect and validate yet unknown environmental risk factors predicting aneurysm presence. I will assess the contribution to disease of all factors detected according to sex. All risk factors will be combined in an aneurysm prediction risk model to understand relative contribution of different risk factors i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assessing Europe's forest adaptive capacity to wildfires from a socio-ecological perspective', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The frequency and severity of wildfires in Europe are expected to increase as climate change intensifies, threatening essential ecosystem services provided by forests. Even regions historically not prone to wildfires, such as northern Europe, are now at risk. A critical knowledge gap exists regarding the ability of forests to adapt to wildfires (i.e., maintaining or adjusting their properties to preserve these services). Previous research has identified indicators to enhance forest adaptive capacity in Europe, but the focus on wildfires has been limited, increasing the risk of maladaptive practices. Given the ecological and socioeconomic dimensions intertwined in Europe’s forests, an integrated socio-ecological approach is essential. However, this approach has not been fully incorporated into the EU Mission on Adaptation to Climate Change, the Green Deal, or the New Forest Strategy for 2030. TOADAPT is an interdisciplinary project aiming to assess Europe’s forest adaptive capacity to wildfires through a socio-ecological lens. The project will (1) identify key forest properties and indicators for wildfire adaptation; (2) build metrics to describe how these indicators enhance adaptive capacity; and (3) quantify adaptive capacity across Europe, identifying hotspots and coldspots for guiding wildfire prevention, conservation, and management. By conducting a systematic literature review, establishing adaptation criteria, a stakeholder questionnaire, and using publicly available EU data, TOADAPT will deliver the first pan-European spatial assessment of forest adaptive capacity to wildfires. This assessment will serve as a foundational model for addressing other disturbances, such as windthrows and bark beetle infestations, aiding practitioners and policymakers in identifying
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Digest and the Exploitation of the Countryside  in the Western Roman Empire (2d cent. BC-3rd cent. AD). Evidence of the water control' to be submitted under Horizon 2020.

assistant: **Abstract**

Every aspect of the ancient world depended on the control and exploitation of the countryside, but scholars have until recently failed to engage with an abundant and detailed material on the subject: the legal texts of the Digest. The thought of the Roman jurists constituted a powerful model for all the minor and local institutions and legal documentation reveals not only rules, but also actual practices and issues of unquestionable historical interest. Amongst the significant amount of legal texts concerning the countryside, the issues of water sharing and that of erosion and flood risks management are particularly well represented, constituting a key element of an essential aspect of the ancient economy, i.e. the agricultural production. However, an overall underestimation has led to a serious insufficiency of methodology concerning these texts, an evident obstacle to its exploitation in a historical perspective. This research proposes to demonstrate how relevant the study of Roman law is for our knowledge of the Roman countryside, by confronting the strikingly unexplored jurisprudential documentation with more traditionally exploited archaeological and environmental sources. The focus on water control is motivated by a will to concentrate on a crucial condition of the exploitation of the countryside, which has raised sufficient interest from the ancient jurists themselves, as well as from the scholars in the past decades, so as to generate enough primary and secondary sources for us to consider. The objective is twofold: first, to establish a clear and consistent methodology for the historical study of the jurisprudential sources; second, to apply it to case studies in order to produce new insights into a fundamental issue of the Roman world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Reducing the levels of preservatives in cosmetic products through active packaging technologies'.

assistant: **Innovation**

Paraben preservatives are used nowadays in a high number of cosmetic packaging products. These preservatives are included in European legislation as components to be reduced in the future. In order to substitute the use of parabens, ACTICOSPACK will produce new packages able to release natural preservatives at the adequate rate and amount into cosmetic products. This mode of preservation enables the reduction of preservatives in the cosmetic formulation and last longer than the actual direct preservative addition, thus prolonging the shelf life of the cosmetics.The main objective of the project is the development of active packages for the preservation of cosmetic products. In concrete,•Active bottle based on PET for shampoo•Active bottle based on PP or HDPE for sun lotion•Active pot based on PP or HDPE for skin care cream
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Country of Words: Reading and Reception of Palestinian Literature from 1948 to the Present' (PalREAD).

assistant: **Concept**

This project proposes a deep and thorough study of Palestinian literature as an early and on-going case of literary displacement. It aims to find new ways to account for and analyse texts, literary production and reading publics that challenge and lie outside conventional conceptions of the nation-state. The proposed methodology will take a novel approach in merging textual analysis with reception theory and reading practices. The project is ambitious in seeking to be the first instance to explore its application on the scale of an entire ‘literature-of-a-nation’. By doing so, the project aims to introduce methodological innovations that can expand horizons beyond textual and national analyses towards interdisciplinary models that contend with the multi-faceted and unconventional dimensions of the Palestinian case, and generate a richer and more nuanced history of its literature.The proposed project will explore, for the first time under one analytic roof, all the geographic fragments of Palestinian literature together, traditionally studied separately, or limited to certain authors or time periods. The project’s novelty also lies in broadening the horizons of literary analysis towards an interdisciplinary and transmedial approach that embeds literary production into a wider cultural web of intersecting media and genres. A creative approach will be developed to overcome the hurdles of working, in the Palestinian case, with few scholarly precedents, and scattered, lost or damaged primary and secondary sources. The project’s four work packages will trace connections and disconnections and transformations of publics and reading practices across dispersed Palestinian literary communities of writers and readers over time. The focus will be on identifying, tracing and elabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering mineralogical and compositional properties of kidney stones: Implications for formation mechanism and potential treatments' under Horizon Europe.

assistant: **Concept**

Kidney stone disease is a vital health problem with a significant increase in prevalence worldwide. It is known that kidney stone formation is affected by medical conditions (i.e., diabetes), environmental factors, dietary habits, and gender, although the relationship between the stone mineralogical and chemical properties (e.g., crystal structure, elemental composition, etc.) to the urine and blood parameters are still unclear. Notably, there is limited information on how the kidney stone mineral phase is influenced by the organic compounds of body fluids during growth and dissolution. Likewise, the kidney stone isotope composition will be recorded during its formation, and subsequently can be used as an indicator of dietary habits, environmental factors, and identifying underlying diseases (e.g., diabetes, osteoporosis). MiKidSton aims to perform a systematic study, from macro- to nanoscale, on a large array of different types of kidney stone samples, to assess: i) the influence of the body fluid (urine and blood) parameters, as recorded in patients, on the characteristics of kidney stone biomineral phases, ii) the relationship of the chemical/isotope composition of kidney stones to their structure, and risk factors (e.g., diet, environment, diabetes, etc.), and iii) the controlling factors for stone formation and dissolution. These objectives will be achieved combining applicant’s expertise and that of PIs, from the two host institutions, on mineralogical and isotope analyses. The outcomes will shed light on connection between kidney stone structure, composition, growth and dissolution with physiological parameters for patients with urolithiasis, with important implications for accurate diagnosis and effective treatment strategies. Finally, MiKidSton findings will ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The game changing drug in Crohn’s Disease : a unique standard of care for a healthy long-term remission' in the context of a Horizon 2020 call.

assistant: **Objectives**

Crohn's disease is a Chronnic Inflammatory Bowel disease affecting over 1.4 million people worldwide. It is the fourth chronic condition impacting the most severely patients’ quality of life, ahead of cancer, visual impairments, and chronic respiratory conditions.  Crohn’s disease is an intestinal disorder causing chronic inflammation of the gastrointestinal tract. It is mainly diagnosed in young people, from 15 to 40 years old. Patients experience excruciating symptoms such as abdominal pain, diarrhea, joints pain and swelling. In some cases, it may even be mortal. Besides this tremendous health impacts, the disease is associated with over €30 billion of annual costs. Exeliom Biosciences is an innovative French AME created in 2016 with a mission to bring a new life to Crohn’s Disease patients. The company is developing a game-changing drug, named EXL01, which relies on a unique commensal bacteria Faecalibacterium prausnitzi. Unlike current Crohn’s Disease treatments, EXL01 achieves long-term remission in mild-to-moderate Crohn’s disease patients without any side effect. It will decrease the number of existing treatments which present a very bad benefit/risk ratio and strong costs in mild-to-moderate patients. Therefore, besides its tremendous health impact, EXL01 will decrease by several million direct and direct costs related to Crohn’s Disease. Exeliom Bioscience has built a team of 5 operational people, and board of 6 scientific and 5 business advisors. The company has also strong collaborations with key international centres and industrials. The company has its own manufacturing process to produce the drug substance and EXL01 has been tested in preclinical studies. Thanks to the EIC Accelerator, Exeliom will reach phase 2a clinical trial and scale-up its manufactur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Harnessing CRISPR-Cas technology for sustainable antibiotic resistance markers'.

assistant: **Objectives**

The active spread of antibiotic resistance in laboratories and industry often occurs through the use of plasmids, which transfer resistance genes between bacteria. To mitigate this, strategies such as non-antibiotic selection methods, stringent containment protocols, and plasmid designs that minimize horizontal gene transfer have been proposed. However, these strategies often involve complex methodologies and require highly trained personnel. Recently, our ERC Consolidator results opened the path for a novel approach to develop antibiotic resistance markers for bacterial selection based on silencing naturally occurring bacterial genes without introducing new resistance elements. Unlike most resistance markers, it lacks a mechanism for degrading antibiotics. Therefore, a low concentration of antibiotics is sufficient to kill bacteria harboring it, minimizing the risk of transferring resistance genes to pathogens.To generate this easy-to-use marker, we will use the CRISPR-Cas system to randomly silence or down-regulate specific genes, including essential ones. We will identify guides that down-regulate genes associated with antibiotic sensitivity and then use these guides along with a Cas-silencer to confer antibiotic resistance. This proof-of-concept will validate the marker's effectiveness across bacterial strains for laboratory and industrial applications, clarify intellectual property positions, and establish industrial collaborations. With a team led by Prof. Qimron, an expert in bacterial defense systems, we anticipate a transformative impact on bacterial selection and maintenance processes. This novel marker has potential applications in medical research, biotechnology, microbiome manipulation, and industrial production. Its deployment will significantly reduce cos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Handheld optical coherence tomography' (HandheldOCT).

assistant: **Concept**

Optical coherence tomography (OCT) is a revolutionizing in-vivo 3D imaging technique for non-invasive optical biopsy addressing medical needs in early diagnosis and effective disease management. OCT has proven its value primarily in ophthalmology but more recently also in a variety of other medical fields. However, wide adoption in health care, a requirement for effective therapy control, has not taken place mainly due to cost limitations and the non-existence of miniaturized mobile devices. Integrated photonics is expected to leverage off many advances made in integrated electronics. Based on photonic integrated circuit technology, HandheldOCT will enable a new generation of handheld OCT systems in the 1060nm wavelength region for optimum tissue penetration with step-changes in imaging performance (4x faster imaging speed), with size (10x smaller) and cost (2-5x cheaper) beyond state-of-the-art. The monolithic integration of silicon nitride optical waveguides, Germanium photodiodes, and micro-optics combined with the hybrid integration of a novel compact all-semiconductor akinetic swept source will enable a mobile, low-cost solution of high usability. HandheldOCT is expected to contribute significantly to a widespread adoption of OCT in point-of-care diagnostics (e.g. for new-born, children, bedridden elderly, home remote diagnosis) and for diagnostic-driven therapy of major sight-threatening, mostly age-related retinal pathologies with the aim to improve patient outcome and reduce healthcare costs.  The endeavour is strongly driven by companies and research organisations with solid expertise in silicon foundry technology, miniaturized laser sources, photonic design and packaging, electronics, and medical OCT system integration. The consortium includes clinicians and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Universal Influenza Vaccines Secured'.

assistant: **Innovation**

UNISEC brings together a European consortium of 3 University partners, 5 National Health Institutes and 3 SMEs, all with leading expertise in influenza vaccine research and development, to work on promising recently developed concepts for a universal influenza vaccine. The consortium is exceptionally strong, interdisciplinary and intersectional in nature, and encompasses a unique combination of scientific and technological expertise from lead identification to clinical trial execution.UNISEC will bring a number of vaccine concepts together into a single study in order to identify, develop and clinically test the 3 most promising leads for a universal influenza vaccine, which must (1) demonstrate adequate (universal) protection, and (2) be technically suitable for development to a marketable product.Preclinical and clinical methodologies will be developed allowing a comparative evaluation of the vaccine concepts. Head-to-head comparisons in animal models will also be performed, with the most promising concepts to then be ready for clinical assessment. Independent comparative clinical studies will be executed and carried out by 5 established Clinical Trial Site partners.The expected impact of the UNISEC work programme will be the resolution of current problems of non-uniformity in the development and evaluation of universal influenza vaccines in Europe by a unified approach using an expert and sustainable vaccine expertise network. The UNISEC results will directly contribute to a timely, longer-term, broader, more effective and cost-effective universal influenza vaccine for the prevention of annual and pandemic influenza.The success of UNISEC will be based on the leading experience of its consortium partners; the proven track record of its clinical trial site partners; an