RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Magnetic Energy Conversion in Fine Nanoparticle Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Magnetic energy conversion using nanoparticles is fundamental to many rapidly developing areas such as environment-friendly nanotechnologies or in biomedicine. Examples include the use of magnetic nanoparticles (MPs) in devices for magnetocaloric refrigeration or for heating in the hyperthermia treatment of cancer. Investing in these areas is imperative if the European Research Area and the European nanotechnologies industry it to gain a worldwide leadership. Essential are scientific developments and also professional training of researchers to provide them with skills in fundamental physics and applied technology aspects. The present proposal's aim in this direction is the career development of Dr. Hovorka combined with the enhancement of his scientific expertise in the field of MP systems. Despite their importance for applications, superparamagnetic and ferromagnetic MP mixtures have been poorly studied and, as a result, the effects of interactions and hysteresis on energy losses and heat generation can presently be analyzed only on the empirical level. The aim here is to develop a solid theoretical understanding of these issues by employing the state-of-the-art multi-scale and atomistic modeling approaches as well as large scale Monte-Carlo methods. The research will be carried out at the host University of York (UK) and benefit from the top-class computational research facilities and the long standing scientific and industrial experience of Prof. Chantrell, who is the world leading scientific contributor in the field. The inter-disciplinary expertise gained during the program as well as new perspectives gathered through the transnational mobility, will put Dr. Hovorka into an excellent position to build an entirely new research portfolio and to effectively interface
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Building The Vertebrate Body' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

My lab is interested in the development of the tissue that gives rise to vertebrae and skeletal muscles called the paraxial mesoderm. A striking feature of this tissue is its segmental organization and we have made major contributions to the understanding of the molecular control of the segmentation process. We identified a molecular oscillator associated to the rhythmic production of somites and proposed a model for vertebrate segmentation based on the integration of a rhythmic signaling pulse gated spatially by a system of traveling FGF and Wnt signaling gradients. We are also studying the differentiation of paraxial mesoderm precursors into the muscle, cartilage and dermis lineages. Our work identified the Wnt, FGF and Notch pathways as playing a prominent role in the patterning and differentiation of paraxial mesoderm. In this application, we largely focus on the molecular control of paraxial mesoderm development. Using microarray and high throughput sequencing-based approaches and bioinformatics, we will characterize the transcriptional network acting downstream of Wnt, FGF and Notch in the presomitic mesoderm (PSM). We will also use genetic and pharmacological approaches utilizing real-time imaging reporters to characterize the pacemaker of the segmentation clock in vivo, and also in vitro using differentiated embryonic stem cells. We further propose to characterize in detail a novel RA-dependent pathway that we identified and which controls the somite left-right symmetry. Our work is expected to have a strong impact in the field of congenital spine anomalies, currently an understudied biomedical problem, and will be of utility in elucidating the etiology and eventual prevention of these disorders. This work is also expected to further our understanding of the Not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ER Function In Virus Infection' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A major challenge in combating significant human pathogens is the inherent variation of viruses that can evolve to evade the host immune response and antiviral treatment strategies. Our research proposes an interdisciplinary approach to identify novel antiviral targets by interrogating the host cell biology of infection by influenza A virus (IAV), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using high-throughput RNA interference (RNAi) technologies. More specifically, we propose to understand the dependency of these enveloped viruses on the host endoplasmic reticulum (ER) machinery for virus replication and propagation and how this increased virus burden activates host-ER stress, including the unfolded protein response (UPR). The UPR is implicated in inflammatory signaling and we will further investigate whether these viruses can modulate host immune responses via this pathway. In summary, we have proposed a hypothesis-driven RNAi screen to generate an overview of common host-cell factors exploited by diverse viruses during infection as well as extensive biochemical and functional validation of any sites of conserved virus-protein interactions. Therefore, this work aims to identify novel candidates for further translational research and development as improved, broad-spectrum antiviral treatments to combat infection and associated pathogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling individual life histories and population dynamics of predatory aquatic insects: the role of body size', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Individual body size can explain a broad array of ecological patterns, including relative abundances, spatial distributions, and diversity of species. Body size underlies the patterning of energy fluxes and responses to perturbations in food webs, and plays a crucial role in individual life histories as it affects many ecological processes including competition, predation, intraguild predation, and cannibalism.This project will be centred on a mutually illuminating use of theory and experiments. Its main objective is to develop and analyze size-structured models of population dynamics and life history evolution of predatory freshwater insects in small fishless water bodies, with emphasis on a strong mechanistic underpinning for all ecological and evolutionary processes accounted for in the models. I will also carry out laboratory experiments and collect data to be able to corectly parameterize the models, and test the applicability of probabilistic reaction norms to measure selected life history traits in predatory freshwater insects.The application of size-structured models and probabilistic reaction norms are novel in the context of freshwater insects, and both methods can improve our understanding of the ecological and evolutionary processes that shape the individual life histories and population dynamics of this important part of freshwater food webs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Networked Society' (NetSoc), addressing dissemination and exploitation.

assistant: **Impact**

The strategic objective of the Networked Society project is to define the requirements for future networks that can seamlessly support the Networked Society of 2020. This will be achieved by enabling an informed dialogue and policy debate between the terrestrial, satellite and content delivery communities and the industrial and social application sectors. This project will create new and lasting relationships between the players in the various sectors and the ICT community which will enable a new set of rich cross sector collaborations.<br/>This work is timely as the exponential growth of traffic in networks and between devices of all types, as part of the emerging Network Society scenario, is already happening and likely to accelerate as M2M communications, augmented reality and many other bandwidth-hungry applications become commonplace. The lead-time needed to generate evolutions in infrastructure capability and capacity is much greater than the time needed to conceive and develop the new generations of amazingly powerful and communications rich services so action now will ensure the correct positioning of the ICT networks issues in Horizon2020.<br/>European ICT infrastructure evolution must not only keep pace with the complex applications and services of the networked society, but it must also understand and anticipate the emergence of sustainable business models in partnership with the sectors. This is important for the European society and economy and to maintain European competitiveness on a global scale.<br/>The objectives of the Networked Society Coordination Action will be achieved through the creation of agendas and position papers, the enhancement of these positions through a continuous dialogue between the sector specific actors and the ICT community, and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Active distribution network' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Considerable amount of renewable energy in Europe represents distributed generation (DG). One of the main barriers for the penetration of DG at distribution network level is the complexity of the interconnection of DG. The overall aim of the ADINE-project is to develop, demonstrate and validate a new Active Network Management (ANM) method of distribution network including DG and enabling solutions to support it. The enabling solutions operate as active components in managing the network allowing easier interconnection of DG units.The solutions cover protection, voltage and reactive power control and planning and information systems of networks. As the result ANM is increasing the security of distribution grids, improving the stability of the grid in fault situations and enhancing the optimal management of network. This adds value at European level by increasing the potential for renewable energy and by enabling more efficient management of distribution network assets for network owners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Multifunctional Dendrimers as targeted drug delivery systems'.

assistant: **Concept**

Multifunctional dendrimers have emerged as potential candidates for targeted drug delivery systems. In the proposed project, dendrons with different surface groups will be synthesized via convergent methodology. New synthetic methods will be developed to obtain dendrimers from combination of such dendrons.Dendrimers having targeting groups and drug moieties conjugated at the surface will be synthesized with the aim of targeted drug delivery to colon and bone. Recently, colon targeting became much more attractive for delivery of drug molecules due to the low digestive enzymatic activity and high residence time compared to the stomach and small intestine. Also, for treatments of local diseases of the colon like ulcerative colitis, Crohn's disease and colon cancer, drug targeting not only reduces the dose to be administered, but also reduces the incidence of possible adverse effects associated with these chemotherapeutic agents. Along with colon targeting, segmented dendrons having bisphosphonate groups, as bone-targeting agents will be synthesized. These multi-functional dendrimers will then be evaluated for their efficiency towards bone adenocarcinoma.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Spiking hybrid edge computing for robust optoelectronical signal processing'.

assistant: **Concept**

SpikeHERO’s ambitious goal is to design, experimentally realize, and validate a heterogeneous system for low-energy communication and data processing at the edge. It will pursue a holistic approach that maximally leverages a co-design process encompassing both novel integration techniques and the exploration of systems combining electrical and optical chiplets. SpikeHERO will exploit advanced integration technologies, beyond CMOS devices and non-von Neumann architectures in the form of electrical and optical Spiking Neural Networks. When used as a fiber to the edge (FTTE) system to demonstrate a novel optical interconnection, SpikeHERO will significantly reduce the energy consumption from 7-10 W to 1-2 W, while increasing the bandwidth from 10 GHz to 30 GHz. The requirements for SpikeHERO are derived from challenging use cases in the context of smart edge devices as well as inputs from industry partners. The utilized co-design process allows to optimize the overall system performance with regards to the energy efficiency of the entire system. After the overall system is specified and the subsystems are developed and tested, integration can take place through an advanced packaging solution. Besides the advances on the hardware development in SpikeHERO, a digital twin including the optical and electrical Spiking Neural Network is developed. SpikeHERO directly addresses the specific objective of the EIC challenge aimed at reducing energy consumption in smart edge devices by exploring and implementing novel materials, 3D multi-die heterogeneous integration, beyond CMOS devices, and non-von Neumann architectures. The project proposes a unique integration of optical and electrical Spiking Neural Networks that operate conjointly to enhance processing speed and power efficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deconvolving the early record of eukaryotic evolution' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Neoproterozoic Era (1 to 0.54 billion years ago) witnessed some of the most dramatic ecological and evolutionary changes in Earth history, which culminated in the appearance and diversification of animals. After almost 4 billion years of bacterial dominance, it took life on our planet just ~250 million years to go from the proliferation of unicellular eukaryotes to diversification of animals. This sequence of rapid ecological and evolutionary changes is thought to be related to unprecedented environmental perturbations, which occurred during this time interval and are recorded in sedimentary rocks. We know these perturbations did happen, but not their magnitude, duration, or driving mechanisms. One of the major limitations of interpreting the data is that each sample represents tens, or even hundreds of years of sedimentation, and contains a mixture of unevenly preserved remains of organisms that lived throughout this time. This project focuses on new methodological approaches at the interface of organic geochemistry, isotope geochemistry, and palaeontology to deconvolve the mixed signals of ancient rocks. Stable carbon isotope analysis on biomarkers of specific groups of organisms would provide insights about the carbon cycle at their habitat; analysing biomarker composition of the first complex microfossils would allow to identify which organisms they were; position-specific isotopic composition of ancient biomarkers might reveal their biosynthetic pathway and thus identify the first ecologically successful eukaryotes on our planet. The study is designed to extract information about the composition and ecology of ancient ecosystems, as well as the history of carbon cycle throughout the critical time of the rise and diversification of complex life. It aims to resol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'POTENTIAL OF INDUCED PLURIPOTENT STEM CELLS FOR THE TREATMENT OF CRIGLER-NAJJAR LIVER DISEASE: A PRECLINICAL SAFETY ASSESSMENT' under Seventh Framework.

assistant: **Concept**

Currently, the only cure for many inherited metabolic liver diseases with severe extra-hepatic manifestations, such as Crigler-Najjar disease (CNI), is liver transplantation (LT). LT goes together with heavy surgery, life-long immunosuppression and important public health costs. Development of less invasive treatments will permit important benefits for the patients and economic savings. Combination of gene therapy and hepatocyte (HEP) transplantation is a promising alternative to LT, correcting the metabolic defect while keeping in place the normal native liver. Nevertheless, the major obstacle has been shown to be the insufficient amount of corrected HEP available for transplantation. Induced pluripotent stem cells (iPS) are endowed with intrinsic self-renewal ability and the potential to differentiate into any of the three germ layers allowing cell amplification before differentiation. As such, iPS are heralded as the most promising avenue for cell-based therapeutics. However, recent evidences indicate that the epigenetic features of iPS are heterogeneous and notably influenced by the tissue of origin of the reprogrammed cells.Hypothesis: HEP reprogramming and differentiation induce profound epigenetic changes that could affect the safety of gene and stem cell therapy combination approach.Objectives: 1) Reprogramming of patient-specific CNI-HEP into iPS. 2) Correction of CNI-iPS by ex vivo lentiviral transduction. 3) Large-scale amplification of the corrected CNI-iPS and differentiation to HEP-like cells. 4) Epigenetic analysis of patient CNI-HEP, CN-iPS and the differentiated-corrected cells. 5) Therapeutic assessment of corrected CN-HEP-like cells into the liver of the CNI animal model.This project will allow a step forward to studying the safety, efficacy and clini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Digital Mythology and Arabic Literature: A Digital Archive to Study the Dynamics of the Reception of Greek Myths in Modern Arabic Literature' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

DIGIMYTH is an interdisciplinary project that adopts the tools of digital humanities (DH) in Arabic literary studies. It plans to create an open access digital archive through which it investigates the dynamics of the reception of Greek myths in Arabic literature produced in Egypt and in the Mashreq in the period 1850-1950. Thanks to its intersectional approach that involves DH, literary studies, historical and religious studies, the project aims at having an impact both on Arabic literary studies and on other fields of research.The general objectives of DIGIMYTH are to investigate how and when Greek myths were introduced into modern Arabic literature and to evaluate their impact on its development. The project envisages two primary specific objectives that address two main questions:1) What are the modern Arabic literary texts containing references to Greek myths? The project plans to digitize relevant texts of Arabic literature that contain such references, and create an open access digital archive. This entails the application of IT tools to Arabic literary studies, which has made little use of digital research so far. 2) What are the dynamics of the reception of Greek myths in modern Arabic literature? While there are studies on the use of myth in Arabic poetry after 1948, they fail to determine the specific function of Greek myths, and to explain how these myths were integrated into the Arabic literary system before 1948. Resting on the data collected in the archive and on an interdisciplinary methodology that involves literary, historical and religious studies, DIGIMYTH aspires to answer the following questions: when and which Greek myths were introduced in Arabic literature? Is there any relation between the place and the reception of a myth, and between the latt