RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Redox sensing and signalling in cardiovascular health and disease' (CARDIOREDOX) under Seventh Framework.

assistant: **Objectives**

We want to determine how oxidants are sensed and transduced into a biological effect within the cardiovascular system. The proposed work will focus on thiol-based redox sensors, defining their role in heart and blood vessel function during health and disease. Although this laboratory has studied the molecular basis of redox signaling for more than a decade, the subject is still in its relative infancy with considerable scope for major advances. Oxidant signaling remains a ‘hot topic’ with high profile studies confirming a fundamental role for redox control of protein and cellular function continuing to emerge. The molecular basis of redox sensing is the reaction of an oxidant with target proteins. This gives rise to oxidative post-translational modifications, most commonly of cysteinyl thiols, potentially altering the activity of proteins to regulate cell or tissue function. One of the reasons there are so many unanswered questions about redox sensing and signaling is the diversity of oxidant molecules produced by cells that can interact with sensor proteins to alter their function. This application is aimed at extending our knowledge of redox sensing and signalling, allowing us to define its importance in cardiovascular health and disease.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Microrobotic Gamete/Zygote IntraFallopian Transfer'.

assistant: **Innovation**

Infertility is a worldwide problem affecting ~11% of the reproductive-age population. Severe cases are currently treated by in vitro fertilization (IVF) and intracytoplasmic injection techniques (ICSI) with high fertilization rates (~95%). However, embryo transfer is still the critical stage with only 32% of the cases resulting in clinical pregnancies. Moreover, the implantation rates per embryo remain very low (~17%) and often the procedure needs to be repeated several times with no success implying a high economic and social cost. Among the different methods used to overcome this issue, gamete or zygote ntrafallopian transfer (GIFT or ZIFT) seems more promising offering appropriate physiological environment for zygote/embryo development at an optimal synchronization between embryonic and endometrial preparation. However, these methods are invasive and involve surgical procedures and anaesthesia to introduce macroscopic imaging and manipulation tools into the female body, increasing the risk of injury and ectopic pregnancies. The goal of Micro-GIFT is to seek for novel approaches to non-invasively transport and release high-quality gametes/zygotes in the fallopian tube in vivo (mice model). For that multifunctional untethered microrobots (~100 µm size) will be developed making use of smart materials and advanced microtechnologies. However, there are major challenges that need to be overcome to bring this technology close to the clinic, such as the in vivo imaging and control of such microrobots, and their removal after use. The project will also provide deeper insights on the contribution of the fallopian tube on the natural embryo development and implantation, being crucial to create more natural procedures with high success rates. The PI has contributed significantly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Detecting Ocean Variability under Filchner-Ronne Ice Shelf'.

assistant: **Objectives**

Direct high temporal resolution observations of the ice column from Filchner-Ronne Ice Shelf (FRIS) will be used to investigate ocean variability in an ice shelf cavity. New data processing techniques will be developed to separate melt rates and strain rates at tidal time scales. The resulting fully-processed melt-rate time series will be used to understand the extent of ocean spatial and temporal variability under FRIS. An eddy-resolving model of the FRIS cavity will be applied, validated using these data, and mechanisms responsible for the observed variability will be identified. The output of the eddy-resolving model will be used to optimise the representation of important small scale processes in an existing coarser version of the model. This will ultimately lead to an improved capability to simulate the global effect of the interactions between ice shelves and the ocean.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A portable easy-to-use system for the assessment of concrete repair' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Concrete damage seriously affects the structural integrity of buildings and other constructions. Builders and owners shift the responsibility for a good quality repair to specialised SME companies who pair and assess quantitatively the repair quality. At the moment most companies use a time-consuming and cumbersome method in which samples of the repair substance are brought onto standard files and afterwards are analysed on adhesive strength by recognised laboratories. This procedure also causes uncertainty about the results. With the R&D proposal an easy-to-use scanner is developed using modern sensor technology which in-situ and non-destructively determines the adhesive strength of the repair. The economic benefits will amount up to 10 MECU/year and the amount of waste (concrete, adhesives, dust) will be reduced by several tons/year in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural analysis of the conformational transitions of the K18 fragment of human tau driven by Hsp70 action' in the context of a Seventh Framework call.

assistant: **Objectives**

The proteins Tau and α-synuclein are causative agents of several neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. In physiological conditions these neurotoxic proteins adopt a disordered conformation but undergo conformational transitions leading to their aggregation and amyloid fibril formation under neuronal stress. ATP-driven molecular chaperones of the heat-shock protein (Hsp) family have been postulated to play a critical role in inhibiting the gain-of-toxic function of these proteins. However, little is known about the binding and activation mechanism of neurotoxic proteins, and of disordered proteins in general, induced by Hsps. Given the dynamic and unstable nature of these interactions and activation cycles, NMR spectroscopy is ideally suited to obtain insight into the nature of these interactions. In the attached application I propose to obtain - by means of novel artful NMR experimental designs, complemented with extensive biochemical and biophysical characterization - a detailed model of the aggregation-prone fragment of Tau bound to the two different allosteric conformations of Hsp70. This will for the first time shed light onto the still unsolved conformational changes in a client protein motivated by the chaperone mode of action. Moreover, I will study several disease-related Tau mutants, the role of cochaperones in this cycle, as well as the effect of inhibitors to better understand the mechanism of Hsp-substrate interaction. In addition, the detailed structural information that will be obtained in this project will provide the basis to chemically optimize available inhibitors and test their cellular effect in the last phase of the project. The opportunity to carry out this ambitious project represents a significant step forward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Quantum Tunneling Device Technology on Silicon'.

assistant: **Innovation**

The subject of this proposal is the design and fabrication of negative-differential resistance (NDR) devices on silicon substrate. The objective is a theoretical and experimental assessment of emerging NDR technologies providing a robust and manufacturability device operation on the nano-scale. The monolithic combination with suitable 3-terminal devices on Si substrate will be elaborated. This combination allows the realisation of novel high speed and digital circuits based on architectures implementing negative-differential resistance devices. Based on this technology both novel circuit families like the hardware implementation of advanced re-programmable neurons as well as a quantitative performance improvement is aimed at.OBJECTIVESQUDOS will make a robust negative-differential device technology on the available on a Si-substrate. The manufacturability, compatibility to Si circuitry, and performance of promising emerging candidates will be quantitatively elaborated. The benefit of this outstanding device functionality will be implemented in novel circuit architectures providing an ultra-high speed receiver, and a threshold logic gate. The latter approach will enable re-programmable advanced neurons. Their large-scale future hardware implementation will be studied in detail and quantitatively compared to present software implementations.DESCRIPTION OF WORKOn a silicon substrate both the Si/SiGe and the III/V material system is experimentally studied towards a manufacturability NDR device. The low growth temperature of the molecular beam epitaxy enables abrupt doping interfaces for inter-band tunnelling diodes (ITD). This approach will be scaled down to the nm-range by self-assembled Ge-dots incorporated in the tunnelling layers aiming at a higher current density at a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European training Network for In situ imaGing of dynaMic processes in heterogeneous subsurfAce environments' (ENIGMA), addressing dissemination and exploitation.

assistant: **Impact**

The ENIGMA network will train a new generation of young researchers in the development of innovative sensors, field survey techniques and inverse modelling approaches. This will enhance our ability to understand and monitor dynamic subsurface processes that are key to the protection and sustainable use of water resources. ENIGMA focuses mainly on critical zone observation, but the anticipated technological developments and scientific findings will also contribute to monitor and model the environmental footprint of an increasing range of subsurface activities, including large-scale water abstraction and storage, enhanced geothermal systems and subsurface waste and carbon storage. While many subsurface structure imaging methods are now mature and broadly used in research and practice, our ability to resolve and monitor subsurface fluxes and processes, including solute transport, heat transfer and biochemical reactions, is much more limited. The shift from classical structure characterization to dynamic process imaging, driven by ENIGMA, will require the development of multi-scale hydrogeophysical methods with adequate sensitivity, spatial and temporal resolution, and novel inverse modelling concepts. For this, ENIGMA will gather (i) world-leading academic teams and emerging companies that develop innovative sensors and hydrogeophysical inversion methods, (ii) experts in subsurface process upscaling and modelling, and (iii) highly instrumented field infrastructures for in-situ experimentation and validation. ENIGMA will thus create a creative and entrepreneurial environment for trainees to develop integrated approaches to water management with interdisciplinary field-sensing methods and novel modelling techniques. ENIGMA will foster EU and international cooperation in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Adaptation to changing nutritional environments: stress and growth regulation in yeasts, plants and plant-pathogenic fungi' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Globally, a large fraction of crops are subjected to fungal diseases leading to great economic losses. Antifungal chemicals currently used are harmful to the environment and therefore due to be replaced in the future. Finding alternatives will depend on molecular understanding of the biology of pathogen colonization of plants with the aim of developing radically new environmentally safe methods of pathogen control. ACE should significantly contribute to research into mechanisms of plant -pathogen interactions and to developing new strategies for pathogen control. The consortium of the ACE research groups combines the expertise in pathways necessary for the transfer of external signals in yeasts, plants, and fungal plant pathogens. Since there is evidence that signal pathways crucial in plant-pathogen interactions are related to yeast pathways, expertise of participant groups on yeast nutritional and stress signal transduction pathways will guide the search for pathways in pathogens and host plants. ACE research groups already successfully studying plant-fungal pathogen interactions will help our network to gain a molecular understanding of signalling pathways involved. Using the most modern genetic and molecular biological technology currently available, e.g. expression profiles of various fungal plant pathogens will provide useful information on fungal adaptation strategies in their host plants. Some of the genes induced by plant-pathogen interactions could encode pathogenicity factors. By studying genome expression and proteomes of the interacting organisms, signal perception, transduction and target factors will be defined that can be genetically modified and knocked out. The mutant phenotypes thus created will allow to draw conclusions on the roles of proteins as pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transport Information Systems Policies' (TRANSINPOL) targeting Fourth Framework.

assistant: **Abstract**

The main objective of the project is the provision of Transport policy requirements for the integration of information, communication and navigation technology in transport and transportation and in particular to assess the effectiveness and efficiency of political actions related to the integration of information, communication and navigation services. Emphasis will also be placed on global navigation (GNSS) and comprehensive payment systems in comparison to existing or emerging alternatives.To achieve this goal major objectives will be: A. to address all aspects of potential interest for policy actions or measures related to this issue. B. to provide information resulting from the assessment of those aspects structured in a way which will be easily accessible for policy decision makers. C. to deliver a framework for policy assessment based on a study of possible scenarios, impacts and the need for more consistency in EU policies. D. to define consolidated functional, social, organizational and institutional requirements with special attention being paid to user views and transport policy needs. E. to provide more in-depth knowledge of the strategic importance of GNSS for Trans European Networks and to identify the potential policy options using satellite based systems to enhance and improve European Transportation Systems. F. to make recommendations and propose the most appropriate actions and measures for developing an information, communication and navigation service environment which will support the Common Transport Policy (CTP). %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spatial patterns in savannas may increase ecosystem resilience and reverse biome transitions' in the context of a Horizon 2020 call.

assistant: **Objectives**

Savannas occupy about one-eighth of the land surface worldwide but the vegetation distribution in this biome is not properly understood. Furthermore, land use and climate change are propelling  shifts in vegetation characteristics and their spatial distribution. Also, at the savanna-forest boundary, where the two biomes are known to exist as alternative states for same climatic conditions, the importance of spatial heterogeneity has been recognized but not well understood. This project will study how the dynamic interaction of vegetation with its environment leads to spatial organization of vegetation in the savannas including at the savanna-forest transition zone. Motivated by recent findings, it will further explore the significance of these patterned structures in increasing ecosystem resilience and reversing transition of ecosystem states. The research will use multidisciplinary knowledge from ecology and applied mathematics. The fellow, Mr. Swarnendu Banerjee, being from a mathematical background but with experience in ecological modelling has the most appropriate foundations to carry out the proposed research. This project will aptly complement his skills by training him in tropical ecology, spatial modelling and state-of-the-art mathematical methods, which will help him grow as an independent scientist in the field. During this project, he will also develop his transferrable skills in terms of writing and communication, project management, language acquisition and networking. The research that will be carried out will provide fundamental insights into the savanna dynamics potentially opening up novel avenues in savanna conservation research. The results generated from the project will be disseminated to the scientific community via scientific conferences and jour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development Of innovative Low pollutant, low noise, low fuel Consumption two-spark ignition Engines for future vehicles for individual urban mobility' under Fourth Framework.

assistant: **Concept**

The individual urban mobility strategy of the years 2000 requires transportation means with high safety systems and low environmental impact. For the utilization in cities with high population density these transportation means will be constituted by two-and-three-wheel vehicles. The main purpose of this research is to develop an innovative engine for such vehicles socially acceptable and characterized by very low pollutant gas and noise emitted by the exhaust and maximum fuel energy utilization (lower carbon dioxide production); Another aim of this project is to generate information for a parallel study on behalf of the European Commission (Pollution Working Group), financed by the Motorcycles Industry in order to define realistic emission standards for the next years. The core of the system is a new concept, air assisted, direct fuel injection, two-stroke engine around which the best of engine/transmission technologies shall be implemented. In fact, in this project the validation and tuning of electronic engine control system for two-stroke engine will be carried out with oil consumption reduction devices and a catalytic system. The new direct injected two-stroke engine presents new lubrication requirements in terms of lubricity, detergency and other aspects such as the compatibility with catalyst. They will require appropriate lubricants and oxidation catalyst formulations which will have to be developed. The objectives of the proposed programme is to work on these new lubrication requirements with the aim of significantly reducing the oil consumption and of developing compatible new oxidation catalyst technology and precious metal formulations specifically adapted for ultra low emissions, air assisted, direct fuel injection, two-stroke engines. The engine components