RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'WEST-EAST LOGISTICS CORRIDOR FOR MULTIMODAL TRANSPORT' (WELCOM) targeting Fourth Framework.

assistant: **Abstract**

Like VADE MECUM, with which it will cooperate, WELCOM is a design study for demonstration of telematics applications on a transport corridor linking Ireland, the Netherlands and Germany towards Poland. It will examine current freight transport user requirements there, as well as telematics needs for freight transport and resource management. With the area facing further demands on an already saturated road network, the study will pay priority attention to technologies for alternative modes or combined transport operations. The study results will lead to a first-outline demonstration plan, as well as definition of sites and participants for pilot testing in the future.Freight in Europe is mainly transported by road; as the road network capacity is overloaded and an enormous increase in freight transport demand is forecasted, there is an apparent need to strengthen the use of alternative modes (short sea shipping, inland waterways and rail) to a maximum degree. This is valid in particular for the West-East-Corridor from Ireland, via the Netherlands and Germany up to Poland where a considerable increase in road transport is expected. Information exchange between all actors involved as well as powerful freight management resource tools at each dispatching site could support the use of multimodal transport chains and therefore need a careful and thorough investigation to detect further possibilities for improvement. The development of appropriate tools for the co-ordinated tactical planning and operation of resources will then increase considerably the transport efficiency in terms of transport quality, safety and costs and an optimised use of different modes in an existing physical infrastructure.The main objective of the WELCOM Design Study is to create the basis for futur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Loneliness Across Time and Space' (LOTIS) under Horizon Europe.

assistant: **Objectives**

The places where people live and spend their time seem to matter for loneliness, but previous research provides mixed evidence for this link. The core argument of LOTIS is that to understand why, when, and for whom places contribute to loneliness, the current perspective on the link between place and loneliness needs to be fundamentally shifted towards a dynamic view. I propose a novel theoretical framework linking a person’s momentary loneliness to how the place is subjectively perceived by this person at a given time, which in turn is influenced by the objective, observable characteristics of this place, characteristics of the person, and individual mobility patterns, i.e., how often, for how long, and in what order places are visited. To test this framework, first, a new dimensional taxonomy that allows describing perceived character-istics of places systematically and comprehensively is developed and applied to the geographically diverse city of Bochum, Germany, using a citizen science approach. Second, the short-term and long-term reciprocal dynamics of place, mobility, and loneliness will be examined in a longitudinal meas-urement burst study where participants track their current location using GPS and report their percep-tions of their current locations and their momentary loneliness four times over a period of three years. Third, the causal processes that link places to loneliness will be tested using laboratory experiments and a natural field experiment. LOTIS has the potential to significantly change how the associations among places, mobility, and lone-liness are conceptualized and studied by (a) moving from a static to a dynamic perspective, (b) incor-porating both objective and perceived characteristics of places, and (c) considering individual mobility pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'User-centred Optimal Design of Electric Vehicle with Smart E-Corners' (SmartCorners) under Horizon Europe.

assistant: **Objectives**

In-wheel motors (IWMs) have become a mature technology that is well-suited for new user-centric electric vehicles (EVs). IWMs can be integrated in multi-functional and controllable modules consisting of the electric powertrain, friction brake and suspension/steering actuation. By combining several vehicle functionalities in a compact solution, the modules offer substantial opportunities to enhance the design and the operation of EVs. This is the starting point of the SmartCorners project. Using machine learning and AI, an adaptive multilayer control strategy will be implemented with historical and current data from the vehicle, its environment, and users, including relevant EV fleets. This approach will pave the way toward software-defined vehicles, ena-bling rightsizing, holistic optimisation, innovative fault mitigation and actuator allocation strategies as well as more efficient, adaptive, predictive, and personalised system operation. SmartCorners will bring a so far un-explored authority level over: i) vehicle design, through skateboard-like chassis configurations; ii) energy management aspects, covering pre-conditioning and predictive thermal management during EV operation; iii) comfort and functional aspects, in terms of user-centric cabin thermal management, and pre-emptive vehicle body control; and iv) dismantling process and recycling of the vehicle. The development and industrialization of the project outcomes will be accelerated by comprehensive and integrated simulation, design and validation methodologies to decrease development time and cost, and support the uptake of AI-based solutions. In con-clusion, SmartCorners will provide a significant competitive advantage of the European industry and contrib-ute to achieve key strategic orientations C and A of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Solupore® - Enabling the Manufacture of Affordable New Treatments to Cure Cancer' (SOLUPORE) targeting Horizon 2020.

assistant: **Abstract**

There is encouraging news for cancer patients, a new treatment, cell immunotherapy, has been delivering spectacularclinical results and is a game changer because it is an entirely new way of treating cancer. Cancer immunotherapy, in whicha patient’s own immune cells are ‘armed’ by cell engineering to target and kill cancer cells, gives levels of complete responsein patients. The first cell immunotherapy drug was approved in August 2017 at a price of $475,000 per treatment. To bringthese life-changing treatments to patients and relieve the European and global healthcare burden they must becomeavailable at affordable costs. The one thing worse than failure is unaffordable success and the challenge with thesetreatments is the complex and high-cost of manufacturing. Current cell engineering methods are very expensive tomanufacture. Avectas has developed Solupore, a cell engineering technology, which delivers cargo to cells and plays acritical role in the manufacturing process. The technology works by temporarily making the cell membrane permeable andallowing cargo into the cell. Crucially, cell health and functionality are preserved while there is a significant improvement onthe process time and costs. Avectas has demonstrated that the pilot system can successfully deliver clinically relevant cargoto T cells. During this project, Avectas will scale and align Solupore to regulatory compliance enabling us to commercialiseit. The emerging and fast-growing cell immunotherapy market is set to be worth $20bn in 2020, with cell manufacturingrepresenting $5bn. Commercialisation of Solupore will take 1% of the €5bn market share by 2024 and will generate globalrevenues for Avectas, building value for the company and creating highly skilled jobs which will result in a high-value,knowl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Metabolic integration by nutrient SENSing'.

assistant: **Concept**

Nutrient sensing enables metabolic homeostasis by matching energy use with fuel availability. The vast body of knowledge on pro-anabolic nutrient sensors, such as insulin and class 1 phosphoinositol-3 kinase (PI3K) signalling exposed the missing links in molecular coordination of catabolism. The cellular catabolism relies on mitochondrial activities and on lysosomal pathway of autophagy, both paced by the biological clock. However, how pro-catabolic nutrient sensors synchronize these catabolic activities is not well understood. We discovered that class 3 PI3K, the only PI3K present in all eukaryotes, is essential for catabolic homeostasis in vivo, but the mechanisms of its metabolic functions are still lacking. We found novel roles for class 3 PI3K in metabolic adaptation to fasting and mitochondrial activity, beyond its established functions in autophagy and endosomal trafficking. These findings form the basis of our innovative interdisciplinary research program that will investigate the molecular bases of Metabolic integration in vivo by a nutrient SENSing pathway of class 3 PI3K (MetaboSENS). In the MetaboSENS research program, we seek to identify transcription factor networks and regulatory complexes of class 3 PI3K that serve its catabolic integrator function. We aim to reveal the physiological oscillation of class 3 PI3K signalling and its reciprocal impact on metabolic timekeeping. Finally, the MetaboSENS project will combine patient analyses and the medical expertise of my team to reveal, for the first time, genetic alterations in class 3 PI3K signalling in inborn metabolic disease. The new mechanisms that we discover may provide therapeutic targets that we will test in the pre-clinical models. Altogether, the MetaboSENS project will redefine our view of systemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Networks and the New Sciences in Edinburgh' under Horizon 2020.

assistant: **Concept**

This project will explore how educational culture from the Venetian Republic and Rome exported scientific knowledge to Britain in the 17th century. It has recently been discovered that an unpublished manuscript commentary on natural philosophy, astronomy, and mathematics written by the largely unknown writer and academic Adam King was the foundational text for instruction in those subjects from the early to mid 17th century at what would become the centre of Britain's Enlightenment culture, the University of Edinburgh. The text betrays an intimate familiarity with the ideas of key individuals (Patrizio, Telesio, Zabarella, Mirandola) and the formal teaching approaches of scholars (Galileo and Clavius) who operated within the Venetian Republic and the Collegio Romano. The project will present a detailed intellectual study that will trace the genealogy of the mechanical observational astronomy, Platonic and Aristotelian philosophy, and proto-empirical scientific methods contained in the Edinburgh manuscript (and the student dictates and Theses spread over 50 years that quote it verbatim) back to their Italian sources. It will offer a comprehensive textual comparison of the use educationalists in Edinburgh, Padua, and Rome made of Cristoph Clavius' educational texts as a hypertextual entry point for the new sciences in the academy in the wake of the collapse of Aristotelian cosmology. In addition to the formal text-based case study and philosophical survey, the project will provide a biographical (of key players) account that highlights how this process of knowledge exchange was enabled by the concerted actions of a network of scholars from across Europe.


**Keywords:** University Disputations, Scholastic Commentaries, New Sciences, European Intellectual Networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Securing Health.Emergency.Learning.Planning' (S-HELP).

assistant: **Concept**

Volatile events such as disasters bring the prospect of rapid contagion and the threat of disastrous impacts for Europe. Vulnerabilities and cascading effects can result in significant injuries, illness and loss of life. Damage to health infrastructure, demand for medical attention, displacement and major outbreaks all place a strain on Health Services. Preparedness and response capabilities of Health Services will directly impact society’s ability to ‘bounce back’ to become more resilient to such devastating shocks.S-HELP will enhance the protection of public health and common grounds for interoperability by significantly ad-vancing the existing knowledge base required for the development of next generation Decision Support (DS) tools and a user-centred Decision Support System (DSS) for better Preparedness, rapid Response and coordinated Re-covery in emergency situations.It will offer evidence-based solutions to improve Health Services performance in emergency management, develop-ing a holistic framework to guide stakeholder needs analysis, and integrating an advanced DS tool-set. The project will execute multi-scenario based end user training, alongside ‘what-if’ analysis. It will simulate 3 multi-factorial and multi-agency scenarios (a chemical explosion; mass flooding; regional bio-hazard), and model the situational and projected evolution of the 3 emergencies to communicate coordinated and collaborative problem solving across agencies. S-HELP will manage end-user knowledge and validate performance in order to use project DS tools and solutions effectively in preparing for, responding to and recovering from an incident. S-HELP will disseminate and exploit the DS tools and solution to complement the role of Health Services in emergency situations.S-HELP will signific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Dynamics of Genome Processing' (DYNGENOME), addressing dissemination and exploitation.

assistant: **Impact**

The vast quantity of information in our genomes must continuously be read out and processed. This is done by proteins, acting either individually or as part of larger protein complexes. How this genome processing operates successfully, given the crowded nature of the DNA track as well as its mechanical constraints and coiling, is a question of fundamental interest.We will investigate the dynamics of genome processing during DNA transcription and replication.  Throughout, we ask the question, what brings these processes to a halt? Focusing on both individual molecular motors and protein complexes, we ask, when do these stall? Both mechanical constraints such as the accumulation of torsional stress and the presence of proteins along the DNA helix may conspire, intentionally or not, to halt transcription and replication.Specifically, we will investigate how RNA polymerases, replicative helicases, and replisomes can be derailed or stalled. These experiments will shed light on the mechanochemical cycle of RNA polymerase, on its motion along a complex track, on the physical interactions that occur between helicases and proteins at termination, and on replisome dynamics near stall. They will also quantify the effects of torsional stress in DNA on the advancement of transcription and replication.The proteins and protein complexes studied here include principal actors in processes essential to cell survival. Understanding the manners in which they can fail will illuminate their mechanism and cellular roles. The powerful single-molecule instrumentation that we have developed in recent years allows one to visualize individual proteins while precisely controlling and monitoring the state of DNA. When harnessed to answer these profound biological questions, we extend not only our kn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimization of formulation and recycling of by-products of solvents and adhesives used in footwear and leather good industry on the basis of toxicological assessment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The project intend to do actions from the industry producing adhesives to improve safety of the products that will be used in footwear industry. So the main participants will be Sees producing adhesives although companies in footwear industry using adhesives and companies commercialising adhesives will also play significant role in the project for studies testing the safety and viability of alternative products. This project is so dealing with the environmental and workers health problems caused by the toxicological properties of the actual formulation of adhesives applied in footwear industry and the risk associates to their use and residues production. Final consequence of the project would be proposals of safer alternative formulations and improved residue management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Peptide Dynamic Amphiphiles for Gene Therapy and Macromolecular Delivery' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The delivery of exogenous nucleic acids and related macromolecules is one of the most encouraging tools for the future of human health. However, the delivery of the required genetic cargo still constitutes an important challenge. Although non-viral vectors are still in their preliminary clinical steps they are rising up as a real alternative for gene therapeutics. Oligopeptides and polymer cell penetrating materials constitute one of the most promising alternatives for the protection, transport and controlled release of different macromolecular cargos. Under the framework of the ERC-Stg_DYNAP we have methodology that employs dynamic covalent bonds to connect peptide/polymer scaffolds with different aldehyde tails (cationic, hydrophobic, glycans, PEGs, etc.). This key synthetic advantage allows the quick identification of different peptide vehicles for customized cargos. The recent interest of important industrial partners in our technology confirms the strong interest and potential impact of our platform. TraffikGene will diversify the potential market applications of this technology and will allow us to reach a higher level of control for the market transference. We will optimize peptide libraries for the delivery of new nucleic acids (i.e. mRNA) in in vitro and in vivo. The potential commercial success will be  maximized by diversification of the applications in gene therapy, cytosolic delivery, antibody transport, cell targeting, blood brain barrier crossing, etc. A market analysis will identify industrial needs, market niches, financial requirements and stakeholders for commercialization. The best future IPR strategy will be carefully evaluated and decided (i.e. product licensing, product development, spin-off, etc.). TraffikGene will allow us to identify and solve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CARING FOR THE ELDERLY IN THE INFORMATION SOCIETY ERA' under Fourth Framework.

assistant: **Concept**

In the information society telematics technology can help break down the social and physical isolation of elderly people and improve not only their health but their quality of life, supporting social and common interest groups regardless of geographical locations. In the RISE System specialised software programmes will use telematics and advanced communications to increase the effectiveness of organisations and health professionals supporting independent living for elderly people. It will also be usable by disabled people or those with special needs. Multimedia, health telematics, smart-cards and portable computers will be used to provide clients with integrated services, including telemedicine, homecare support, home environmental systems, and various teleservices including entertainment, communications and special interest groups support.