RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Myeloma stem cell network: A translational programme identifying and targeting the early myeloma cell hierarchy'.

assistant: **Concept**

Multiple myeloma is an incurable disease of malignant plasma cells which accumulate in the bone marrow, for which novel and effective therapeutic approaches are vital. The European Myeloma Network (EMN) has recently been set up to investigate this disease, which may serve as a paradigm for incurable cancers. It is our belief that by defining the myeloma stem cell (MSC), this will accelerate our search for a cure for this debilitating disease. Our proposals in pursuit of these aims are based on 3 integrated goals: 1. To establish a structural network with secure funding to underpin our co-ordinated research activities. 2. To formulate a scientific framework to define the MSC and its relationship to the tumor microenvironment. 3. To utilize insight from our scientific investigations to devise therapy, including immunotherapy. For Goal 1, the EMN has set out to interweave European expertise, which is at the forefront of MM research as demonstrated by the high quality of research publications. For Goal 2, the MSCNET has delineated key strengths and limitations in the current state of the art. We will set out an umbrella strategy to examine the key issues relating to the MM stem cell, introducing novel technologies to do so. For Goal 3, it is clearly vital to define the stem or `feeder' cell in MM if the disease is to brought under long-term control or for curative treatment. This remains a pivotal question which will dictate future development of targeted therapy.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Control of Adult Stem Cell Differentiation' (CASCD) under Sixth Framework.

assistant: **Objectives**

All tissues seem to contain a population of stem/ progenitor cells, which mediate normal repair. When this mechanism fails or is overwhelmed degeneration results and leads to disease. Mesenchymal stem cells (MSCs) can be isolated from adult tissues and are excellent candidates for regenerative medicine, which aims to repair damaged tissues at the cellular level. MSCs are self-renewing, able to differentiate into cells from multiple tissues and are the subject of at least 3 human clinical trials to evaluate t heir efficacy. However, the mechanisms controlling MSC proliferation and differentiation are not well understood. The work described in this proposal will investigate potential mechanisms by which MSCs regulate and accomplish their differentiation.This study will compare the microRNA (miRNA) profiles of undifferentiated MSCs, differentiated MSCs and donor-matched control cells. MiRNAs are small RNAs that bind messenger RNAs affecting their translation and altering the protein complement of a cell. MiRNAs have been shown to regulate fundamental biological processes including differentiation of some stem cells, but to date no role has been described for miRNA in regulating MSC behaviour. An improved understanding MSC differentiation will improve MSC-based therapies, as well as raising the profile of European stem cell research. This will in turn improve European regenerative medicine, which will be of great economic importance as chronic degenerative conditions affect an increasing proportion of the population in aging Western societies.Funding this proposal will aid the reintegration of an EU citizen who gained 10 years research experience in the US at prestigious research institutes and a Biotechnology company at the forefront of developing stem-cell based therapies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The missing stellar physics component for atmospheric evaporation of exoplanets' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The aim of this ambitious project is to use stellar physics to overcome a roadblock in our understanding of how exoplanets lose their primary hydrogen-helium atmospheres and make space for secondary, life-enabling ones. The best observing window for evaporating primary atmospheres are transit observations in the near-infrared metastable helium lines. However, correctly interpreting the observed absorption is extremely challenging. How much of the planetary helium is in the metastable state is controlled by a very small, but incredibly hard to observe part of the host star's extreme-ultraviolet spectrum. Not knowing this controlling factor makes quantitative estimates of the planet's evaporating atmosphere currently impossible. In this project my team and I will put helium triplet spectroscopy on a solid stellar physics footing for the first time, leveraging my extensive background in stellar X-ray astronomy. We will develop a procedure to reconstruct the crucial part of the stellar extreme-UV spectrum accurately from observed coronal X-ray spectra of stars, vastly outperforming the current highly uncertain estimation methods. We will model the outflowing planetary atmosphere to predict helium absorption as a function of stellar extreme-UV irradiation, and for the first time add accurate physics of X-ray bright stellar flares. We will use an unprecedented approach to test our predictions: We will conduct transit observations of exoplanetary helium during different phases of a host star's activity cycle, i.e. observationally isolating the changing stellar extreme-UV irradiation as a driver of helium absorption for the first time. This high risk - high gain project will turn the phenomenology of the helium window to the exoplanetary atmosphere into true understanding, by p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Functional connectome of brainstem circuits that control locomotion' to be submitted under Horizon 2020.

assistant: **Abstract**

Locomotion is a complex motor act that is used in many daily life activities and is the output measures of a plethora of brain behaviors. The planning and initiation of locomotion take place in the brain and brainstem, while the execution is accomplished by activity in neuronal networks in the spinal cord itself. Recent experiments have provided significant insight to the organization of the executive spinal locomotor networks. However, little is known about the brainstem control of these networks. Here, I propose to provide a unified understanding of the functional connectome of the key brainstem networks that control locomotion in mammals needed to select appropriate locomotor outputs. To obtain these goals we will develop a suite of transgenic mouse models with optogenetic or chemogenetic switches in defined populations of brainstem neurons combined with the possibility to use state-of-the-art cell-specific electrophysiological and anatomical connectivity studies. We will reveal the functional organization of  ‘go’ and ‘stop’ command systems in the brainstem that are directly upstream from the spinal locomotor networks and the mechanisms for how spinal networks are selected. We will further functionally deconstruct the next network layer in midbrain structures that control the ‘go’ and ‘stop’ command systems. Our research takes a specific approach to provide mechanistic insight to the integrated movement function by building the motor matrix in a functional chain from the locomotor–related spinal cord neurons that have been identified to midbrain neurons. A segment of our research will link these networks to locomotor impairments after basal ganglia dysfunction. The work has the potential to make a breakthrough in our understanding of how complex movements are genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Monitoring and Evaluation of Spatially Managed Areas (MESMA)' (MESMA).

assistant: **Concept**

The increasing pressures upon the marine realm call for a well planned approach of further spatial development of this area. An ecosystem-based approach to fisheries, the increasing demand for sustainable energy, coastal defence systems, building materials and safe transport routes and the need to protect marine habitats and species all compete for the same valuable space. At the same time climate change will alter the composition and functioning of marine ecosystems, calling for a robust approach of future spatial planning that also takes cross boundary developments into account. MESMA will supply innovative methods and integrated strategies for governments, local authorities, stakeholders and other managerial bodies for planning and decision making at different local, national and European scales. This will also comprise an easy accessible information system to gain support from politicians, stakeholders and the public in general for difficult (inter)national decisions that will be needed for sustainable use and protection of this vulnerable area. This data system, containing information on the distribution of marine habitats and species, economic values and benefits and human uses and its effects will also be an interface between science, policy and decision makers.MESMA will supply strategic tools for sustainable development of European seas and coastal areas. The major challenge is to combine an optimized use with a sustained ecosystem of high quality, taking into account ecological and economic differences. By studying and comparing different national situations and solutions from a selected number of sites throughout Europe and by determining common features and differences, including the socio-economic settings and requirements, an integrated toolbox that can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PHOTOVOLTAIC POWER STATION ELBSPEICHER HAMBURG' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

A 50 kWp PV generator will be installed in an historic facade of 4 storeys. The building is 120 years old and is situated in the Hamburg fish market. The project will promote architectural integration of PV in buildings, and will play an important role in future campaigns by Greenpeace to promote PV energy. In particular, the project will demonstrate the integration of PV into facades which are considered as historic. The existing power to the building comes from a district CHP system which will be partly displaced, reducing CO2 production, especially in summer when the CHP plant is less energy efficient.Installation of 50 kWp PV laminates tilted 25 deg. southwards on top of the 120 year old Elbspeicher" building, integrated in shed-constructions, in combination with district heating by KWK units. PV generator : 32.8 kW 259 m2 and 17.2 kW 136 m2, Voc = 400 V 14% efficiency, Siemens Solar M110Inverter : 50 kW, 90% efficiency, 3 x 400 V out.Installation : to be completed by June 1996Monitoring : according to Ispra guidelines."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Human Subcortical-Cortical Circuit Dynamics for Remembering the Exceptional' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Our memory system is optimised for remembering the exceptional over the mundane. We remember better those events that violate predictions generated by the prevailing context, particularly because of surprise or emotional impact. Understanding how we form and retrieve long-term memories for important or salient events is critical for combating the rapidly growing incidence of pathologies associated with memory dysfunction with huge socio-econonomic burden. Human lesion and non-invasive functional imaging data, motivated by findings from animal models, have identified subcortical structures that are critical for upregulating hippocampal function during salient event memory. However, mechanistic understanding of these processes in humans remains scarce, and requires better experimental approaches such as direct intracranial recordings from, and focal electrical stimulation of, these subcortical structures. This project will characterise human subcortico-cortical neuronal circuit dynamics associated with enhanced episodic memory for salient stimuli by studying direct recordings from human hippocampus, amygdala, nucleus accumbens, ventral midbrain and cortex. Within this framework, I will elucidate the electrophysiological mechanisms underlying amygdala-hippocampal-cortical coupling that lead to better memory for emotional stimuli, extend the hippocampal role in detecting unpredicted stimuli to define its role in orchestrating cortical dynamics in unpredictable contexts, and discover the neuronal response profile of the human mesolimbic dopamine system during salient stimulus encoding. The predicted results, based on my own preliminary data, will offer several conceptual breakthroughs, particularly regarding hippocampal function and the role of dopaminergic ventral midbrain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Post-Quantum Side-Channel Attack Resilience', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In the rapidly evolving digital age, the advent of quantum computing poses a significant threat to current cryptographic standards, leaving sensitive information vulnerable to quantum-based attacks. This project addresses the urgent need for resilient cryptographic solutions capable of withstanding quantum threats, focusing on developing and validating post-quantum cryptographic algorithms that are resistant to side-channel attacks.Our solution involves the creation of a robust framework for evaluating the resilience of cryptographic algorithms against quantum and side-channel attacks. By leveraging advanced mathematical models, simulation tools, and hardware implementations, we aim to identify and mitigate vulnerabilities in existing cryptographic systems, ensuring a high level of security in the quantum computing era. Collaboration with industry partners and academic institutions will play a crucial role in validating the effectiveness of our solutions across different platforms and use cases.This project not only aims to advance the field of cryptography in response to quantum computing challenges but also to establish a set of standards and best practices for developing and implementing post-quantum cryptographic solutions, ensuring the long-term security of digital information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ADvancing user acceptance of general purpose hybridized Vehicles by Improved Cost and Efficiency'.

assistant: **Objectives**

ADVICE aims at increasing the number of HEVs up to 10% of all vehicles registered in the mid-term range. This will be achieved by focusing on a market segment called “premium class”, which covers medium class, upper medium class and luxury vehicles up to SUVs. This segment is facing severe problems in reaching European environmental exhaust targets, when running on fossil fuel only, not the least due to the considerable vehicle weight.In ADVICE three physical demonstrator vehicles are built, ranging from mild-hybrid, plug-in-hybrid to full-hybrid and – concerning fuel type – from gasoline to diesel-driven.In addition, it will be shown that the whole range in between these demonstrator vehicles can be well covered by means of validated simulation, yielding a complete coverage of the whole “premium class” segment.ADVICE aims for a reduction of exhaust and CO2 emissions on WLTP of 20% and a 25% increase in electric driving range for P-HEVs at a maximum premium cost of 5% for HEV (15% for P-HEV) with respect to the best in-class non-hybrid diesel vehicles. Particular attention is devoted to optimum driveability and drive performance, which are essential when purchasing a “premium class” vehicle and thus crucial to achieve the market penetration aimed at. These objectives will be accomplished by:* Architecture-level  hybrid powertrain solutions, suited to be modularly applied to different segments  to increase their volumes while reducing costs* Advanced predictive control strategies and model predictive control strategies, taking the entire vehicle into account (not only the hybrid part)* Novel optimised approaches in the aftertreatment system* Newly developed high-temperature electronics, enabling novel strategies and approaches for energy- and thermal-management* Multi-co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bringing to market the world’s first integrated medical cooling system for minimizing brain damage in stroke patients.' (CUCUMBER) under Horizon 2020.

assistant: **Objectives**

Stroke-related disabilities remains a major challenge faced by patients, their families and healthcare systems worldwide and is estimated to cost healthcare systems over €45B/year. In Europe, there are over 1.1M new incidences of stroke per year, a third of which will result in permanent disabilities such as limited mobility and affected cognitive function. These handicaps are a result of the brain damage caused by blocked blood flow to the brain, as well as further damage following the recanalization of an arterial blockage. Targeted temperature management (TTM), also known as 'brain cooling', is a method that has proven effective in reducing brain injury in sudden cardiac arrest patients. Extrapolation of TTM to stroke will have a tremendous impact on patient outcomes, however, the limited functionalities of current cooling technologies prevent this realization.The CUCUMBER consortium, whose expertise range from engineering, manufacturing, clinical neurology and stroke, are working to change this paradigm by developing CoolConnect, the world's first cooling device that accommodates the needs of stroke treatment to improve patient’s outcome, survival, and neurological outcome. CoolConnect is an integrated device composed of 3 components (RhinoChill, BrainCool, and BrainTemp sensor), which come together to address the 3 critical phases of brain cooling, 1)Early cooling, 2)Cooling during reperfusion and 3)maintenance cooling. CoolConnect is the only solution in development designed for this purpose.FTI grant is requested to fast-track the market launch of CoolConnect by 2024, to ensure broad and sustainable uptake in the following years. Our main aim is to validate CoolConnect in a large, multicenter trial, and to implement all market access and communication activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Barrel Array Diagnostics And SenSing'.

assistant: **Objectives**

In array-based sensing, synthetic receptors are appended with chromophores (reporters) and arrayed in various formats. The arrays are treated with analytes that displace the reporter to different extents and the outputs are interpreted by computers to identify the analyte. This has not been demonstrated for arrays of structured de novo designed peptides, which have many advantages over the synthetic small molecules currently used. Through an ERC Advanced Grant, ABEL (340764), we have designed peptides that form novel protein barrels. We have proof of principle results that show that protein barrels can be used for this kind of array sensing. Through this award, we will employ an expert peptide design chemist to address technical issues needed to translate the protein barrels into a technology platform. They will: make and test many variants of the barrels in array formats; establish the best surfaces and attachment chemistries for barrel arrays; and develop algorithms for analysing the outputs. Second, we would employ an expert in biotechnology innovation and management to conduct customer discovery to understand better the market and potential route to exploitation for our technology.