RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Human blastoids: a drug discovery platform for women’s reproductive health'.

assistant: **Objectives**

The first weeks of human pregnancy are crucial as early abnormalities or insults result in infertility. Therapeutics acting at the onset of embryonic development would offer huge opportunities to improve public health through effective family planning and to reduce an ongoing global fertility decrease with profound economic, social, environmental, and geopolitical consequences. Unfortunately, a drug development program on human embryos is unfeasible due to the inaccessibility and scarcity of embryos, and to ethical issues associated with them. As a result, the attrition rate of drugs for reproductive health is high for all major In Vitro Fertilization (IVF) and pharmaceutical companies.Recently, an alternative approach arose from stem cells self-organizing into structures closely resembling pre-implantation embryos (blastocysts), which we termed blastoids. Because stem cells can be largely multiplied, this embryo model provides a scalable and ethical alternative amenable to drug screens, thus opening numerous possibilities for therapeutic breakthroughs. Here, I propose to use human blastoids to discover molecules for women’s reproductive health.Blastoids offer a unique opportunity to establish a drug discovery program for early pregnancy and an alternative to the use of animal and human embryos. As such, this path has the potential to decrease the cost of drug development and to increase the rate of approved drugs for reproductive health. The aim of BLASTOID-DISCOVERY is to investigate the commercial feasibility of using blastoids as a new and highly cost-effective tool in the discovery of therapeutics for reproductive health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Direct Air Carbon Capture designed for the Gigaton Scale' (StackDAC) targeting Horizon Europe.

assistant: **Abstract**

Direct Air Capture (DAC) is set to play a crucial role in solving one of the most complex problems of our time: bridging the emissions gap and cleaning up both historical and hard-to-abate emissions. It’s the only solution that can permanently and verifiably remove carbon dioxide from the atmosphere. But as promising as DAC is, it’s also an enormous technical challenge, considering that while CO2 levels are high enough to drive our climate change, they make up just 0.04% of the air we breathe.To truly reduce atmospheric CO2 levels and recover gigatons of atmospheric CO2 each year, DAC technology must be environmentally friendly, socially responsible, and scalable at a global level.At RepAir, we’re developing the technology that will make make this a reality with our cutting-edge, fully electric DAC technology, engineered as a trully scalable solution at the gigaton scale.


**Keywords:** Direct Air Capture (DAC) ; Carbon Removal ; Net zero Technology ; electrochemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transport of Heat in hEteRogeneous Media' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Geothermal represents a promising energy source to satisfy the growing energy needs with only minimal environmental impacts. To develop and test new technologies for energy production and storage in geothermal reservoirs, deep understanding of heat transport in fractured media is critically needed. The THERM project focuses on the investigation of heat transport and associated thermo-hydro-mechanical (THM) processes occurring during the lifetime of a geothermal reservoir. Fractured reservoirs, such as those found in enhanced geothermal systems, are characterized by a strong hydraulic and transport complexity coming from the fractures’ surface roughness, from their arrangement in networks, and from the interaction of the fractures with the surrounding rocks. As a result, the characteristics of the hydro-thermal flow which occurs when a cold fluid is injected into a hot fractured rock mass are controlled by fracture network discontinuities and properties of fracture surfaces themselves. While progresses have been made in characterizing and modeling subsurface heterogeneity in flow and solute transport processes, the effects of multi-scale subsurface heterogeneities on heat transport remains an open question. I propose new 3D fully coupled physical-based numerical models at different scales associated to state-of-the-art field experiments to develop a quantitative understanding of complex coupled processes occurring along fluid-rock interfaces during fluid circulation in geothermal systems. The main objectives are (i) to characterize the combined effect of fracture-scale and network-scale heterogeneity on flow and heat transport phenomena, and (ii) to design new field experiment to jointly measure the integrated THM behavior of fractures. Thanks to THERM, the ER will recei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Prognostic value of upar forms in colon and breast cancer'.

assistant: **Innovation**

Investigation of the clinical prognostic value of soluble urokinase plasminogen activator receptor (uPAR) forms in blood and tissue extracts from patients with colon and breast cancer, aiming to develop new methods which will aid in the decision-making needed in the management of cancer patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Process optimisation and fouling control in membrane bioreactors for wastewater and drinking water treatment' (MBR-TRAIN).

assistant: **Innovation**

The research project MBR-TRAIN provides an Early Stage Research Training on process optimisation and fouling control in membrane bioreactors for water treatment. Membrane bioreactors (MBRs) which combine biological treatment with a membrane separation step are among the most promising emerging technologies in the water treatment sector. As membrane fouling has been identified as a major barrier to sustainable MBR application, MBR-TRAIN undertakes dedicated efforts to characterise and investigate both biolo gical and physico-technical aspects of this phenomenon and develop strategies to control it. The findings shall be used to advance the modelling of MBR processes in order to improve the prediction of plant performance and economic operation. The scope of t he offered research projects ranges from laboratory scale experimental set-ups to pilot- and full-scale operational plants. The consortium of MBR-TRAIN comprises 10 partners from the water-industry, research institutes and universities across Europe repres enting a cross-section of relevant disciplines, sectors and regions. Due to its consortium composition, the MBR-TRAIN project provides an ideal framework for young researchers to prepare for future assignments in intersectorial tasks pursuing a research ca reer in both academic institutions and industrial enterprises. MBR-TRAIN offers the young researchers a well organised and structured training programme in a technology field of growing relevance. They will benefit from a tutored PhD thesis work with addit ional scientific training offered in short-courses or workshops. The exchange of personnel between the participating institutions will train adapting to work in different research structures. In order to bring benefit to the researchers¿ careers beyond a m ere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Scaling-up multiphase microchemical reactors' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of chemical engineering and its unit operations is to transform raw materials into products (e.g. commodity and specialty chemicals like pharmaceuticals). However, motivated by the awareness of the world’s finite resources, it is desirable that these products are obtained in a sustainable, efficient and environmentally acceptable fashion, which means minimising waste and energy use, and make increasingly use of renewable raw materials. Novel efficient manufacturing technologies, flexible chemical plants, integrated process development, and innovative design approaches will provide the solutions to this important challenge.To reach these goals further research efforts in process intensification are needed, and there is also the demand for novel concepts for continuous reaction systems. Furthermore, many of the relevant chemical transformations involve multiphase flow, either gas-liquid, immiscible liquids, or solid-liquid. Thus, to successfully design these novel continuous reaction systems a detailed understanding of multiphase flow systems and the underlying physics of the transport processes associated with the various length scales is needed.Therefore, the aim of the proposed research is to understand interfacial transport processes and the scale-up of the involved transport coefficients in more detail. This is accomplished by identifying the physical mechanisms of heat and mass transfer on the micro- and milli-scale using non-invasive, laser-optical measurement techniques, and to use these experimental results to develop predictive multiphase flow models for computational fluid dynamics (CFD). The obtained results will bridge the gap between the micro- and milli-scale, and will directly impact the efforts in process intensification and sustainable advanced m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanoengineered superconductors for power applications' in the context of a Sixth Framework call.

assistant: **Objectives**

High temperature superconductors (HTS) have an enormous potential for significantly improving existing power systems, such as cables, motors, magnets and generators, because higher power densities and reduced losses can be achieved by replacing copper wires . Superconducting materials will also enable completely new technologies, such as fault current limiters. As examples for innovative applications, advanced energy systems for all-electrical" ships, off-shore wind mills and transportation systems should be mentioned. Although research on the materials aspects of HTS has been highly successful in the past, the development of low cost - high performance HTS materials remains a key factor for success and requires significantly more basic and applied materials re search, in order to bring these emerging materials to the market. The development of HTS materials for power applications is a highly multidisciplinary task involving chemistry, physics, materials science and electrical engineering. Currently, three quite different routes are addressed: (i) the construction and implementation of first "real" industrial systems based on HTS materials, (ii) the development of "coated conductors" that will result in an economic HTS wire production, and (iii) the controlled nano-engineering of highly textured bulk and thin film materials to enhance flux pinning and thus to improve the material performance.  The planned RTN will strongly accelerate these developments by forming an international research team with leading experts i n different areas, who are willing and keen to train young researchers on a broad range of topics, from basic flux pinning investigations, advanced chemical processing of nano-engineered HTS materials or new concepts for low ac loss conductors, to industrial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low dose x-ray diagnostic imaging: a new modality for planar and three dimensional applications in rheumatology, orthopaedics and chest radiography (EOS)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

EOS targets the assembly and clinical test of a new instrument for low dose diagnosis radiology. The instrument innovation lies in a capability of X-ray imaging with doses 10 to 100 lower than existing techniques, and of rendering a radiological image in three dimensions without using a costly and irradiating CT scanner examination. The instrument will be clinically tested in three hospitals for three radio logic imaging modalities of particular importance: scoliosis, chest imaging and soft tissue diagnosis. The project relies on a number of breakthrough innovations in detection and algorithmic which have been quantitatively demonstrated by the partners of the consortium on test beds, and will allow the realization of a dedicated prototype fully adapted to a hospital environment and its validation on a recruitment primarily of children, but also of adult patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Alternative Chemicals and Materials integrating Safety, Sustainability, new Production technologies and Socio-economic aspects' in the context of a Horizon Europe call.

assistant: **Objectives**

The AlchemiSSts project will demonstrate the applicability of the Safe by Design (SSbD) framework aiming at developing and implementing safer and more sustainable alternatives to surfactants, plasticizers, and flame retardants that, being present in daily life products pose a high risk for the human health and the environment, thus considered substances of very high concern (SVHC). To this end, up to seven case studies, accounting with the relevant actors in the value chain are proposed in the project, and they will serve as proof of concept to test the SSbD framework against within its different 5 steps. The general objective of the project will be achieved by addressing specific goals such as the development of the alternative substances itself, the compilation of robust and reliable evidence for a Proof of Concept of the SSbD framework, the development of a certification methodology promoting the implementation of the SSbD concept in the industrial network. Another key pillar of AlchemiSSts project relies on the implementation of integrated approaches and tools to support safety, sustainability and social assessment based on interoperable FAIR data and models. In addition, robust data on sustainability indicators and information for assessing the impact of the outcomes of the project towards a suite of zero pollution targets will be delivered for each case. For all these relevant aspects, AlchemiSSts will be assisted by stakeholders to ensure social acceptance and economic of the foreseen innovative advance materials.


**Keywords:** sustainable, safety, validated, proof of concept, value chain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NOVEL THERAPEUTIC NANOHYDROGEL FOR ACUTE AND CHRONIC PAIN TREATMENT TARGETED TO THE NERVES FASCIA'.

assistant: **Innovation**

Worldwide chronic pain conditions are by far the greatest cause of disability. It has an enormous negative impact on quality of life and on personal and professional plane. Chronic pain is an important cause of depression, more sickness absences at work, productivity losses, unemployment, etc.). Chronic pain is one of the major reasons (30%) why people exit the labour market prematurely. 20% of current population in Europe suffers from chronic pain (102 mill.) and up to 50 % of that pain comes from wrongly treated acute post-operative pain. The total direct and indirect healthcare costs for chronic pain disorders in Member States have an EU average of 2.4 % of GDP and a cost of 271 billion euros per year. When acute pain is not properly treated in the first few days, it can become chronic. About 40-60% of patients report pain chronification after surgery. Current medicines do not prevent chronic pain from the start and have side effects. “Fast track” approaches have started to take the lead in pain management policies. Based on these approaches I +Med´s team works since 2014 in the development of FasNaGel, a new nanomedicinal product, unique in the world. It consists of a biocompatible and biodegradable injectable carrier, made of porous nanostructured hyaluronic acid hydrogel containing a non-steroidal anti-inflammatory drug that i) efficiently, provides a 100% of functional recovery after surgery in one third of the time, ii) is easy-to-use by medical staff, and the most important iii) increases by 80% the treatment effectiveness. FasNaGel will reduce the overall treatment costs in Europe, deducting indirect costs coming from acute pain up to €149 billion. The objective of this proposal is to be able to perform a thorough feasibility study for the validation of the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Addressing metalloenzymes for clean energy production with advanced embedding schemes and quantum mechanical methods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The proposed project aims to develop and apply quantum mechanical (QM) methods targeted at metalloenzymes, for which the methods in use today often fail. The failures are caused by inaccuracies in either 1) the underlying protein structures, 2) the employed QM method or 3) the embedding method that describes electrostatic interactions between the protein environment and the active site (i.e. metal and its nearest ligands). The MetEmbed project addresses 1), 2) and 3) with hydrogenases and polysaccharide monooxygenases (PMOs) as target enzymes. Hydrogenases mediate the reversible conversion of dihydrogen into hydride ions and protons, while PMOs have shown great potential for biofuel production. The overall objective is to investigate the reaction and spin-state energetics for key intermediates in the two proteins' catalytic cycles. To ensure that the underlying structures are accurate, extensive molecular dynamics (MD) simulations with tailored force fields and QM/MM methods will be employed. The adequacy of the QM methods will be ensured by using accurate, multireference QM methods that are known to be well-suited for transition metal systems. Two new multireference QM methods will be applied, namely a multiconfigurational density functional theory hybrid and the density matrix renormalization group method. These methods have high potential for metalloenzymes, but have until now only found little use in this area. To address the effect of the protein electrostatics, an accurate embedding scheme that, contrary to most QM/MM methods, includes the polarization of the environment will be used. The combination of 1) accurate structures, 2) accurate QM methods and 3) polarizable embedding schemes is unprecedented for metalloenzymes. The MetEmbed project will thus predict ene