RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding Metabolic Activation of Dendritic Cells in Non-Alcoholic Fatty Liver Disease' (Metabo3DC), addressing dissemination and exploitation.

assistant: **Impact**

Non-alcoholic fatty liver disease (NAFLD) is a major global health problem with no approved treatments, and dire outcomes for patients. The pathogenesis of NAFLD is clearly linked to metabolic alterations, and is primarily characterized by excessive hepatic triglyceride content. Over time, metabolic dysfunction induces hepatic inflammation through mechanisms that remain poorly understood. This advanced disease stage, called non-alcoholic steatohepatitis (NASH), significantly raises the risk of hepatocellular carcinoma, cardiovascular disease and type-2 diabetes. My recent work has helped demonstrate that: 1) changes in conventional dendritic cell (cDC) populations in liver are closely associated with the development and the resolution of NASH in humans, and 2) extracellular metabolites can modulate cDC cytokine production and responses by rewiring their intracellular metabolic programs. Together, these studies indicate that alterations of the local hepatic metabolite environment could affect cDC function and thereby drive NASH pathogenesis.cDCs coordinate innate and adaptative immunity through cytokine secretion and antigen presentation. However, their role in NAFLD pathophysiology not well defined. In this ambitious multidisciplinary project, my objective is to systematically dissect the immuno-metabolic programs and functions of hepatic cDC during NASH progression and regression. First, we will identify disease-associated cDC subpopulations and their intracellular metabolic programs. We will then determine whether these cDC subtypes associate with specific local metabolic microenvironments in the liver in relation to histological features of NAFLD. Finally, we will determine how metabolic manipulation of cDC affects their immune function in the context of NASH. The pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Smart European Networks for Sensing the Environment and Internet quality' to be submitted under Horizon Europe.

assistant: **Abstract**

The project aims to develop new tools and methods to operate global telecommunication networks as large-scale distributed sensors. We will develop novel photonic techniques for measuring the deformation of optical cables by interferometric means with high sensitivity and high resolution, making use of low-phase-noise laser sources. We will address the on-chip integration of such lasers, overcoming one important limit of present systems, i.e. of being bulky, costly and not suitable for mass-production and large scale implementation. At the same time, we will design an advanced network architecture in which the newly-developed sensing elements are made visible to the network control layer together with standard elements, and the information is processed and turned into exploitable information. This will provide the network with intelligence and awareness, in turns enabling: a wiser use of resources towards a more sustainable operation of global networks; self-healing functionalities by timely recognition of soft-failures and identification of correction pathways; time-critical tasks such as recognition of ongoing hazard and the implementation of actions to protect population and critical infrastructures.Our consortium brings together optical networking experts, photonic developers, seismologists and network providers and has a strong focus on long-term experimental tests in fibres shared with data traffic. Through unprecedented data collection campaigns and thanks to a multi-disciplinary approach, we will advance the interpretation of collected data and make them available to the wider scientifc community, aiming for a synergic and smarter exploitation of global networks for telecommunications, scientific research, citizen protection and the management of highly-populated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metadata management and production system for empirical socio-economic research' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project develops a Metadata Management and Production System for simple to complex Social Science surveys, based on the comprehensive experiences of the partners and analysis of user needs. Preservation and publication of metadata for a growing comparative database are central for validation and cumulation of knowledge based on empirical evidence. It enables data producers and providers to manage small to large collections of metadata, especially to make metadata capture at the source more efficient. MetaDater supports management and production tasks for existing and new databases. This includes the transfer of metadata to user front-ends. MetaDater is an infrastructure instrument to supply researchers with reliable, high quality, standardized and durable information about Social Science Survey data. It helps to enhance the general quality of metadata in social research and facilitate access to comparative databases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Union – United States Research Cooperation Network: Link to the United States' under Seventh Framework.

assistant: **Concept**

This project seeks to enhance the awareness of and participation in, by European scientists and research organisations, U.S. national collaborative funding schemes in order to help strengthen cooperative research with American counterparts under bilateral science and technology agreements. Because the U.S. federal research funding structure is highly decentralised with many different U.S. government scientific entities involved depending on the fields of interest, accessing potential opportunities requires a clear understanding of the various funding schemes available. This project proposes to map opportunities of collaborative funding schemes and rules for participation. Potential obstacles to participation will be analysed so that they may be avoided or that solutions may be found. Analysis of the bilateral S&T cooperation agreements with respect to reciprocity conditions and the monitoring of European researchers participating in the U.S. collaborative programmes will be conducted to improve the effectiveness with which the EC and EU national authorities ensure matching reciprocity from the United States. The project will raise awareness and disseminate information of the Project’s findings and analyses through a multi-faceted information network consisting of a website, electronic and physical communications including awareness-raising events, and a virtual help desk to provide assistance to European researchers on the intricacies of U.S. programmes and funding opportunities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bringing Regenerative Medicine into the market: Allogeneic eASCs Phase IB/IIA clinical trial for treating Rheumatoid Arthritis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Treating Rheumatoid Arthritis (RA) is a crucial challenge for the health systems. RA is the most common inflammatory arthritis, affecting 0.5% to 1% of the general population worldwide with little variation of the prevalence among countries.The current pharmacological management of RA involves early intervention with synthetic disease modifying anti-rheumatic drugs (DMARDs) either singly or in combination. Despite all those treatments, RA remains as an unmet clinical need where several concerns about long term treatments based on biologics have been arisen (Bongartz, 2009) while there are still approximately 20-40% of rheumathoid arthritis patients that do not have an adequate response to anti-TNF (Vander CB, 2006).The preclinical data obtained by the REGENER-AR consortium in a RA efficacy model in mice using allogeneic eASCs by intravenous route, demonstrated that mesenchymal expanded adult stem cells (eASC) extracted from adipose tissue have a large potential for treating RA.REGENER-AR consortium has defined a clinical translational project which aim is to develop a broadly available and clinically applicable treatment for RA by exploiting the biology of living human eASCs. To do that, the consortium is developing an Advanced Therapy Medicinal Product (ATMP)  based on allogeneic eASCs for the treatment of RA (product internal code, Cx611) and ready for starting the clinical research (IMPD and clinical protocol has been approved by the regulatory agencies in January 2011).To accomplish this goal, it will be necessary to test this product through a phase Ib/IIa clinical trial in order to define the safety and feasibility of the systemic administration of allogeneic eASCS in patients with RA, but it will be necessary as well to advance in the difficulties that prevent ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a novel dust cleaning and collecting device for the production and cleaning industry based on electrostatic principles' (ELECTROCLEAN), addressing dissemination and exploitation.

assistant: **Impact**

Our idea is to develop a novel and effective dust cleaning and collection device to be used both for continuously collecting fine dust particles from products in line production and for periodic cleaning of dust from surfaces of products and production facilities The major barriers are to make this work on even the fine dust particles down to size 05m without touching the surface and without re suspending the dust which imply no use of compressed air which today is the normal way of removing collecting dust.We will overcome these challenges by specific developments to fulfill our objectives to create:1 A bond-breaking device based on the combination of an alternating field and polarized air to work on dust particles gt 05m2. A dust moving component using airflow less than 0 05m s for transporting the dust particles away from the surface in a controlled manner towards the cathode collector3 A cathode collector to attract the dust for collection within a range of up to 20cm from the cathode4 An internal dust transport unit made of smaller charge shifting cathodes in a matrix with a nozzle to connect to a disposable unit for safe dust depositing without suspension risk.Furthermore the Electroclean project will investigate the electrostatic influence on quartz silicate dust type since there is only limited scientific literature dealing with this subject Enhancing the scientific understanding in this field will provide our SME community with access to new valuable knowledge with the potential of creating new innovative products based on new methods for electrostatic bond breaking for cleaning silicate dust particles which is a major problem for industries like semi conductor high voltage fuses optical disc production and electronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Artificial intelliGence applied to pRecision farmIng By the use of GNSS and Integrated Technologies' (AgriBIT), addressing dissemination and exploitation.

assistant: **Impact**

AgriBIT aims to increase the precision, accuracy and continuity of services to deliver improved Precision Agriculture (PA) services to farmers, leading to a reduction in costs through decreased use of inputs (water, energy, fertilisers, pesticides), lower environmental impacts and increased production yields. It positions its innovations both at the level of intervention on the field and the capturing of the effects of PA over time, intelligently exploiting the information acquired before, during and after direct intervention on the field.AgriBIT combines augmented GNSS and EO information with 1) on-field and on-machine sensors and actuators, and 2) expert agricultural knowledge to deliver simple, high precision and continuously available services. It develops and extends advanced Artificial Intelligence algorithms to fully exploit this rich set of inputs to recommend actions to farmers building on past history and present context and to ease their workload through improved automation.AgriBIT delivers operational services (3 GNSS-enabler services, 8 GNSS-enabled services) and 1 European sourced high precision GNSS affordable receiver that cover the complete value chain of PA, from monitoring to application and precise and automated machinery guidance. With 70% of European farmers active in small to medium operations, AgriBITs European sourced high precision GNSS receiver at an affordable price is a major technological and societal contribution to Europes farming community.  AgriBIT delivers collaboration services supporting farmers and service advisors, but also 3rd party developers for whom open interfaces are provided both at service level and as channels for advanced Big Data Analytics innovations.Over 36 months, AgriBIT includes 20 months piloting at 3 locations, 12
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ENGRAMS IN TRAUMATIC MEMORY: FINDING NOVEL THERAPEUTIC AVENUES IN DEPRESSION AND PTSD.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Despite 70% of people are going to experience a traumatic event throughout life, only 3.9% are going to develop post-traumatic stress disorder (PTSD). Curiously, people who develop PTSD also present a higher risk of developing Major Depressive Disorder (MDD). Thus, 50-70% of PTSD patients will live with a diagnostic of MDD, which in terms of prognosis means poor response to treatment and worse symptomatology. Despite the clinical relevance of this comorbidity, it remains unknown if there are shared molecular mechanisms. Impairments in fear memory and learning were related to PTSD and MDD, in association with atrophy and synaptic loss in the hippocampus (HPC). In turn, the HPC plays a crucial role in fear memory, encoding the contextual information related to the fearful stimulus. Thus, we propose that maladaptive fear memory due to hippocampal dysfunction can also contribute to MDD, explaining the high co-morbidity between PTSD and MDD. Importantly, preclinical research focus on fear memory have provided us with promising knowledge for potential PTSD therapeutics. For instance, the regulation of glucocorticoids in the golden hours after trauma to prevent memory consolidation, the use of beta-adrenergic blockers to disrupt consolidated memories, or different psychotherapeutic approaches to enhanced memory extinction. Recently, the advances with chemo- and optogenetic technics have allowed the identification and functional modulation of neurons involved in encoding a specific memory (engrams), thereby allowing a highly refined study of memory substrates. Despite these advances, the use of such approaches in genetic animal models for the study of psychiatric comorbidities is still poorly explored. We believe that this combination can bring new insights and methodological p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Solid State Energy Efficient Cooling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

We propose to develop a high efficiency heat pump and an air conditioner based on a magnetic refrigeration cycle. Both devices will operate at room temperature. The core materials research will centre around the identification, synthesis, modeling and production of low cost, environmentally friendly magnetic refrigerant materials that operate in low magnetic fields and the synthesis and production of inexpensive permanent magnets – the two key materials components of a magnetic cooling engine. By involvement of an SME, a medium scale materials manufacturer and a major systems end-user, we will ensure industrially-guided feedback on materials design and performance. Furthermore, we will have the opportunity to integrate and assess our materials with the systems components (heat exchangers, motors and pumps) required to produce a heat pump and an air conditioner by completion of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AQUAculture infrastructures for EXCELlence in European fish research towards 2020' (AQUAEXCEL2020), addressing dissemination and exploitation.

assistant: **Impact**

AQUAEXCEL2020 aims to integrate top class European aquaculture research facilities of very diverse nature, covering all relevant scientific fields for research and innovation in aquaculture, from genetics to technology through pathology, physiology and nutrition. It will put in place a user-friendly one-stop access to high-quality services and resources from 39 installations covering both established and new aquaculture species, all types of experimental systems as well as sequencing facilities. Giving a prominent place to EU aquaculture industry research needs through a strong involvement of the European Aquaculture Technology and Innovation Platform, it will enable excellent research and sustainable innovation to both public and private sector. It will benefit from the support of the ESFRI infrastructures EMBRC (Marine Biology) and ELIXIR (Life Sciences data) and bring aquaculture research specificities to their agendas.AQUAEXCEL2020 will be a key vehicle in the improvement of aquaculture research practices to the benefit of industry through finalized research and innovation, and of excellent science through the development of highly innovative methods and approaches such as Virtual Laboratories, standardized experimental fish lines and nano-sensors. It will also benefit to society through the development of methods for sustainable aquaculture, such as the use of cleaner fish to control parasites or Integrated Multitrophic Aquaculture, and also through a better management of animal experiments for research according to the 3 R's, Reduction (via e.g. capitalization of data and provision of stable experimental fish lines), Refinement (via a better control of experimental procedures) and Replacement (via e.g. Virtual Laboratories).As a whole, AQUAEXCEL2020 will provide a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cell-type-specific identification of mRNAs translated by cannabinoids in the hippocampus: from signaling to behavior' (CANCELLTRANS) under Seventh Framework.

assistant: **Objectives**

The hippocampal region is critically involved in memory formation and cannabinoids including delta9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, are known to impair hippocampus-dependent memories. Previous findings uncover the role of the mammalian target of rapamycin (mTOR) signaling pathway and protein synthesis underlying the long-term amnesic-like effects of THC. Thus, the regulation of mTOR-dependent mRNA translation after THC exposure could be an important process that elicits the distortion of hippocampal plasticity leading to memory impairment. The aim of this proposal is to characterize cell-type-specific mRNAs following THC treatment and evaluate the functional implication of such events on THC-induced memory impairment. To do so, we propose 1) to isolate and analyze actively translating mRNAs following THC exposure. This will be achieved by performing cell-type-specific isolation of ribosome-associated mRNA from CA1 hipocampal pyramidal neurons followed by standard genomic profiling technologies such as RNA-sequencing, 2) to evaluate the functional implication of some identified mRNAs on THC-induced memory impairment. This research project will allow not only to address the scientific issue in vivo at an integrated level, but also to yield important insights into the distortion of mechanisms involved in memory formation. The project should allow the fellow to learn new techniques by using powerful state-of-the-art technologies and the host institution will provide the best environment and knowledge, offering all the necessary equipment and qualified experts in the field.