RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'In vivo assessment of the optical cochlear implant performance: coding strategy optimization'.

assistant: **Objectives**

Hearing loss affects millions of people worldwide. In cases of pronounced cochlear dysfunction, an electrical cochlear implant (eCI) can partially restore hearing sensation by electrically stimulating the auditory nerve. Until now, the eCI is the most successful and broadly used neuroprosthesis, with more than 1 million users worldwide (WHO, 2021). However, eCI hearing is far from normal: eCI users can typically not comprehend speech in noisy environments, because the electrical signal spreads widely and excites a large number of neurons of the auditory nerve, which limits the number of separate perceptual channels.Using optogenetics, it is possible to stimulate the auditory nerve using an optical cochlear implant (oCI). As light spread can be better confined in space, oCIs offer lower spread of excitation and, hence, greater frequency selectivity. This way, future clinical oCIs promise more perceptual channels, allowing for more pitch appreciation and better understanding of speech in noise. However, there are many challenges in the development of the oCI en route to clinical application. Importantly, we are currently missing a holistic assessment tool for preclinical efficacy which could serve oCI optimization. I will develop a set of methodological and computational tools to assess the oCI performance in vivo, in the Mongolian gerbil. First, I will use the brainstem responses to map the frequency activation of separate optical channels. Second, I will develop predictive models that derive the optogenetically and acoustically evoked responses of the midbrain, applying machine learning techniques. Third, I will use the above-mentioned tools to identify the optimal coding strategy for the oCI. This project will accelerate the development of the oCI, and provide benchmar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'XXI. IVR World Congress in Legal and Social Philosophy' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

IVR 2003" purports to give Young Researchers from the European Union Member States and Associated States the Opportunity to participate in the XXI.IVR World Congress in Lund, Sweden, Aug. 12 - 18, 2003. The purpose of IVR is the promotion of legal and social philosophy at national and international level. The general topic of the World Congress is "Law and Politics, in Search of Balance"' The intention behind the Congress, as such, is the investigation into the role of general theories--in particular legal theory and legal philosophy--with respect to the presentation and teaching of the law.Since YRs from European countries ought to be familiar with the mainstream concerning the complex relationship that obtains between law and politics, "IVR 2003" encourages YRs from both Member and Associated States to participate, at subsidized costs, in the XXI.IVR World Congress."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Measurement of the labour market effects of disability on household welfare' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Disability imposes many costs upon the individual. This project proposes to measure the costs of disability which occur through the operation of the labour market. One of the major innovations of the project is that it examines the effects of disability on the labour market in both a static and dynamic framework. The project has three main parts: first is the estimation of household welfare for the disabled via their labour market characteristics, secondly the measurement of the factors affecting labour market transitions for the disabled and finally the estimation of whether and how much discrimination against the disabled exists in the labour market. The initial part of the project involves the estimation of participation and labour supply for the disabled. This will enable us to examine how the labour market experience for the disabled differs from that for the fully-abled. From the estimation of participation and labour supply equations, measures of household welfare via the real wage function can be calculated and the welfare loss owing to the different labour market outcomes for the disabled can be evaluated. This analysis may also permit estimation of the welfare effects of various proposed reforms. The second part of the project introduces the dynamic framework in to the analysis. Here we propose to examine transitions between labour market states for the disabled and evaluate what factors are important. This can be performed using the techniques of multiple state transition models and the estimation of the relevant hazard functions to determine whether and how disability affects labour market transitions. For example, it will be possible to estimate how disability affects the probability of becoming unemployed and also how it may
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Replacement of Copper Fungicides in Organic Production of Grapevine and Apple in Europe' (REPCO) under Sixth Framework.

assistant: **Objectives**

The objective of REPCO is to replace copper fungicides in organic agriculture by new measures for control of downy mildew (Plasmopara viticola) in grapevine and scab (Venturia inaequalis) in apple. Both major European organic crops strongly depend on copper fungicides with application of a total of 38 kg copper per ha permitted between 2002 and 2006. Permitted amounts will be reduced stepwise during the following years (Council Regulation (EEC) 2092/91, Annex II) to avoid environmental risks. In European countries where copper fungicides are already out of use, production of organic apples suffers severe economical problems because of insufficient scab control. Potentiators of resistance, organically based fungicides and biocontrol agents will be screened and evaluated in grapevine and apple. The risk of pathogen evolution during use of novel control measures will be estimated to allow the development of sustainable strategies. Effects of crop management practices in organic agriculture on overwintering of V. inaequalis will be assessed. Novel disease control measures and knowledge will be integrated into organic management systems. 'Pipeline' products already under development elsewhere will be included and where necessary optimised in their use. Implementation by end-users and industries qualified for commercialisation of project findings will be strongly emphasised. SME partners will ensure a strong link between end-users and research. At the end of the project several compounds and biocontrol agents will be delivered to qualified industries for development of products for use in organic agriculture. Additionally, knowledge of integrated use of control measures will be delivered to organic growers. Knowledge and material will be exchanged with ongoing projects on pot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Suppression of programmed cell death in industrial scale biological production systems' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Apoptosis is the genetically determined form of controlled cellular elimination that accounts for most of the cell death that takes place in-vivo. It is also the primary mechanism of cell death during the in-vitro cultivation of mammalian cell lines used in the production of biopharmaceuticals. In recent years, lab scale studies have indicated that the suppression of the apoptotic pathway during the synthesis of these high value products can substantially increase the productivity of the culture process. In the demonstration proposed here, we will develop new cell lines that incorporate anti-apoptosis genes and will demonstrate the impact of this strategy on the efficiency of state of the art industrial-scale biopharmaceucical production processes, and then make them available to the biotechnology industry.- Assessment of transfectants over-expressing Bcl-2 protein, generated in previous programme, in a state-of-the-art biopharmaceutical manufacturing process was completed;- Bank of NS0 clones expressing different levels of Bcl-2 protein secured and selected clones characterised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Surface-supported Molecular ARchiTectures: THEory Meets Experiment' in the context of a Horizon 2020 call.

assistant: **Objectives**

The future of nano-electronics has been proposed to be switching soon from bulk 3D materials to lower dimensionalities. The self-assembly of well-designed molecular precursors on appropriate surfaces is a very promising route towards 1D/2D materials with a high degree of long-range order and tailored functionalities. However, the synthesis of well controlled molecular networks is a lengthy and expensive trial-and-error process because growth driving forces are poorly understood and generally hard to investigate. Research in the field can be improved and sped up thanks to optimization guidelines derived from first principles modeling of the elemental steps of the growth process. This project aims to develop a synergistic theoretical and experimental line of research on the on-surface synthesis of novel surface-supported molecular architectures. The candidate is a well experienced computational quantum chemist which will integrate a team of experimentalists and theoreticians expert in the field of molecular assembling and reactivity at surfaces. Novel methods in density functional theory will be employed to simulate complex molecular configurations and reactions paths. On one side the theoretical activity will provide predictive modeling of the mechanisms of surface-assisted reactions and fundamental insights for the interpretation of microscopy and spectroscopy observations. On the other side, precisely targeted experiments will provide the necessary validation of the theoretical approaches employed and will stimulate the most pertinent directions over which the theoretical modeling should be addressed. The ultimate goal of the project will be to build an irreplaceable theoretical tool to rationalize experiments and to drive them towards optimal synthesis routes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Non-conventional target approach for drug discovery against neurodegenerative diseases: Nrf2 upregulation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

As a result of the aging population of the developed countries, neurodegenerative diseases (NDD) afflict an ever-increasing number of people. Alzheimer’s disease (AD) is the most prevalent NDD with more than 36 million people currently affected worldwide. Although AD has been studied for more than a hundred years, its “ultimate” trigger is not yet completely understood. Focus for over two decades on amyloid beta (Aβ) and tau protein, as targets to develop a neuroprotective medicine to delay Alzheimer’s disease (AD) progression, has so far failed. AD is developed as an extremely complex network of events, a fact that has led to the proposal of the “multifactorial hypothesis”. AD, to be defined, must be seen as interconnected processes, rather than independent pathways triggering the final consequences of the disease. In considering the genetic target-based approach, it should be taken into account that familial AD is less than 1%; thus, at least 99% of patients suffer a sporadic form of AD. It seems therefore reasonable to follow non-genetic approaches. For instance, the free radical theory implies progressive cell damage with age, leading to enhanced mitochondrial DNA mutations, futile mitochondrial Ca2+ cycling with excess ATP consumption, oxidative stress and ensuing mitochondrial dysfunction. Based on these observations, the objective in this proposal is the design of selective “multi-target drugs” able to modify two or more key steps in different AD related pathological pathways. By mixing several targets with tuneable properties in one molecule it will be possible to affect several pathways at once and therefore, affecting “redundancy” processes underlying AD. Non conventional selected target will be auto-defensive pathways (phase II gene expression) within the cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Implantable nitinol net to combat pathological corneal shape deformations' (HUMANeye), addressing dissemination and exploitation.

assistant: **Impact**

The global costs from visual refractive errors will reach some 1.2 trillion in 2019. This type of disability is on the increase and it is predicted that it will affect 10% of the World population by 2050. Pathological corneal shape deformations (PCSD) are a common cause of severe refractive error that tend to occur in young adults, considerably reducing both their quality of life and work productivity. Current treatment options are severely limited. The compromised cornea cannot withstand aggressive reductive laser surgery. Corneal transplantation gives highly unpredictable results, necessitating multiple operations that lead to spiraling treatment costs of over 14k per patient.HUMANEYE is a breakthrough dome-shaped corneal net fashioned in medical-grade titanium. Implanted deep within the cornea, it potently corrects refractive error and halts disease progression in PCSD. It uniquely matches the natural architecture of tissue layers throughout the entire tissue, leading to simple reproducible implantation, 70% higher success rates and 66% stronger refractive correction than current ring-shaped implants on the market today.The HUMANeye project unites two hi-tech SMEs, to manufacture the technology and push it to market, with two leading European ophthalmic care centres to prove its worth in the clinic. From HUMANEYE launch in 2023 until 2027, our SME partners will together generate 103.6m in cumulative revenues and 54.9m in profits. Rollout with an established commercial license partner will generate 21 internal and 48 external jobs in our value chain. 938k successfully operations will help 295k patients to better employment and save 20.1bn in direct public healthcare and indirect productivity costs.


**Keywords:** cornea, pathological corneal shape deformation, kerato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Human-bird interactions from the Roman period to the end of the Middle Ages: Italy and England in their European context' to be submitted under Seventh Framework.

assistant: **Abstract**

The political and financial crisis that brought about the collapse of the Roman Empire caused important historical and cultural changes at the Roman-Middle Ages transition. Bird bones recovered from archaeological sites may contribute to our understanding of this important historical process as they are part of the wider material culture of past human societies. They are particularly suited to reflect the complex network of economic, social, religious, political and domestic circumstances and behaviours which characterise past human communities.The project will apply a much needed rigorous scientific approach to the study of bird remains from Italian and British archaeological sites dated to the Roman and Middle Ages periods. Questions such as the development of bird husbandry techniques, the relative importance of different species, their use in ritual activities and the association between birds, social status and environmental changes will be investigated. The research will expand the results of previous work using new zooarchaeological methods (diagnostic zone analysis, observation of butchery marks and biometric analysis), which, in conjunction with the written sources and historical components, will guarantee a holistic approach to the research questions.The project will be particularly innovative in applying such interest to the historical period, to a relative neglected but very important cultural transition (i.e. Roman-medieval) and also by placing its main case studies - Roman and medieval Italy - in their European context.The project will also represent an excellent example of how the barriers between research in humanities and science can be brought down to approach the evidence in a fully interdisciplinary mode. The project will provide evidence that is lik
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AdvancEd aicRaft-noIse-AlLeviation devIceS using meTamaterials', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

AERIALIST aims at the disclosure of the potential of metamaterials to envisage innovative devices for the mitigation of the civil aviation noise. Goal of AERIALIST is to contribute to the identification of breakthrough technologies to achieve the noise reduction targets foreseen by the ACARE Flightpath 2050. AERIALIST fully complies with the envisaged SRIA, aiming at the development of efficient methods for the modelling of metamaterials tailored to aeroacoustic applications and at the conceptual design of innovative devices for aircraft noise mitigation. The focus will be on the reduction of the noise propagating outside turbofan nacelles, exploiting the unconventional properties of acoustic metamaterials to modify noise scattering patterns. Scattering cancellation, hyper-focusing, and noise trapping techniques will be investigated to achieve virtual scarfing of intakes, suitable treatment of outflow ducts and enhancement of shielding effects. As a key enabling factor, efficient and reliable theoretical models and numerical tools will be developed and validated during AERIALIST. Despite the tremendous growth experienced by the research on metamaterials during the last decade, this aspect still deserves a thorough investigation. The AERIALIST activity will lie almost entirely in the TRL range 1-2, with the possible evolution up to level 3 (experimental proof of concepts) of the most promising ideas. In summary, AERIALIST will: i) extend the acoustic metamaterial theory to take into account the effect of realistic aerodynamic flows; ii) develop suitable numerical methods to simulate the behaviour of acoustic metamaterials in aeronautic operating conditions; iii) realize the experimental validation of the most promising concepts; iv) analyse the technical feasibility of n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Road Modular Sensor  (SmaRMS) Prototype Testing and Commercialization Viability' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Smart Road Modular Sensor  (SmaRMS) Prototype Testing and Commercialization ViabilityThe main purpose is to prepare business plan and to perform first development/testing activities for Smart Road Modular Sensor  (SmaRMS). In the first iteration the sensor will measure temperature of the road at three levels in depth and will be completely energy independent, easy to install and implement into existing Wi-Fi network and road weather information systems (RWIS). The modular nature of the sensor will in future enable the exchange of sensoric module in order to expand its application range.