RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting host-transposon interactions during germline development and their impact on genome integrity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Mammalian genomes are filled with transposable elements (TEs), whose activity is usually silenced by DNA methylation. However, during the fetal phase of germline development, DNA methylation is naturally lost as part of the epigenetic reprogramming of the future gametes. This leads to the transcriptional activation of transposition-competent TEs, which normally represents a threat to genomic integrity and species fitness. How fetal male germ cells (a.k.a. prospermatogonia) mechanistically cope with TE reactivation and protect the integrity of the genetic material?Preliminary data from the lab indicates that TEs acquire both permissive H3K4me3 and repressive H3K9me3 marks in mouse prospermatogonia, and may be subject to early transcription termination. I will investigate whether these regulatory patterns may allow prospermatogonia to tolerate active TEs and even integrate them into their own developmental program. Focusing on this unique cellular model provided by prospermatogonia, I will 1) assess the dynamics of H3K4me3-K9me3 marks using single cell multimodal chromatin profiling in relation to prospermatogonia development, 2) analyze TE transcriptional features, 3) study the 3D coordination of TE regulation within the nucleus and 4) investigate whether TEs participate to the prospermatogonia gene expression program by providing regulatory sequences. I believe this project will identify novel principles in TE regulation with immediate relevance for the field of reproductive biology. Knowledge will be gained regarding the origin of infertilities, but also for other pathological contexts such as cancer and neurodegenerative diseases, whereby DNA methylation loss and TE reactivation are commonly observed.


**Keywords:** Transposable elements ,  germline development ,  ep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Alzheimer's disease-treatment targeting truncated Aß40/42 by active immunisation' (MIMOVAX).

assistant: **Innovation**

Alzheimer's disease (AD) is the most common form of dementia in humans. According to the Alzheimer Association there are currently 12 million patients worldwide with estimated social costs for every patient reaching 40,000 per year. At present, no effective treatment is available to stop the progressive neuro-degeneration and associated cognitive decline in AD patients. AD is characterized by the abnormal accumulation of amyloid plaques in the brain.These plaques mainly consist of the Amyloid-(A) peptides Aß40/42 derived from the Amyloid Precursor Protein (APP). Immunotherapeutic treatment targeting Aß led to amyloid plaque reduction and had beneficial impact on disease progression in animal models. However, the first phase II clinical vaccination trial in AD patients using full length Aß42 as antigen had to be discontinued due to severe neuroinflammatory side effects including brain infiltration by autoreactive T-cells. In humans most of the amyloid plaque material is formed by N-terminally truncated and modified Aß derivatives. These truncated Aß species are correlated with increasing severity and early onset of neurodegeneration in AD patients.In light of the characteristics of amyloid composition in patients, these truncated Aß peptides are highly attractive targets providing neoepitopes not present on parental APP. The Mimotope technology presented in this proposal will be used to create antigens mimicking potentially pathological B-cell epitopes on truncated Aß. A Mimotope-based AD vaccine targeting truncated forms of Aß would therefore induce a safe antibody response exclusively reacting with the pathological Aß molecules but not with parental APP and would avoid the induction of autoreactive T-cells. Thus the MimoVax vaccine will provide an innovative, safe, cos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrons in Arctic Air: Exploring the drivers behind integron diversity in the Arctic atmosphere and integron integrase gene expression under simulated atmospheric conditions.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the current context of the “One-Health” concept, the importance of assessing and monitoring microbial biodiversity and ecology in all environmental compartments is becoming increasingly apparent. However, although the atmosphere participates in worldwide dispersal of microorganisms and their genetic material, it has been relatively little studied compared to freshwater, marine and soil ecosystems. Recently, concerns have been raised about the atmospheric dispersal of antibiotic-resistant genes (ARGs). Interestingly, ARGs are part of integrons, important bacterial genomic elements that facilitate the dispersal and acquisition of genetic material. In this context, the main objective of the two-year IntegrAAir project is to assess the ecodynamic of integrons in the atmosphere and assess their impacts on human and ecosystems health. It relies on the hypothesis that aerosolization can impact integron dynamic by inducing the integron integrase gene expression and thus mobilizing new genetic elements from the environmental gene pool. In order to respond to this hypothesis, two main sub-objectives are planned: (i) Understand the drivers behind integron complexity in the Arctic boundary layer using an omics approach, the Arctic being an ideal environment to attempt to focus primarily on environmental integrons, as it is little impacted by anthropogenic sources; (ii) Understand whether aerosolization can affect integron dynamics (gene gain and loss). We will investigate the integron integrase gene expression under simulated atmospheric conditions, using unique atmospheric chambers developed by the host research team. Overall, the project will provide new insights in the fields of aeromicrobiology and microbial ecology, as well as for public health, with regard to the impact of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development and risk assessment of a field-based portable biosensor using genetically-modified bioluminescent bacteria'.

assistant: **Innovation**

Genetically modified (GM) bioluminescent whole cell microbial biosensors offer great potential for the measurement of pollutants in contaminated land, surface and groundwaters; but cannot currently be used in the field due to the risk of GM release. The project will research various physical and biological strategies for containment of the GM bacteria within the biosensor instrument and conduct a lab- based risk assessment and field trials at various European sites. The project is led by a biosensor company and has workpackages for selection and engineering of strains, comparison of cell immobilisation techniques, development of prototypes, risk assessment and field trials, and project coordination and dissemination. The result will be prototype portable biosensors, which can be operated with a negligible and thus acceptable risk of GM release.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ground Deformations Risk Scenarios: an Advanced Assessment Service' (DORIS).

assistant: **Innovation**

DORIS is an advanced downstream service for the detection, mapping, monitoring and forecasting of ground deformations, that integrates traditional and innovative Earth Observation (EO) and ground based (non-EO) data and technologies. The service delivers innovative products tailored for Civil Defense authorities. DORIS integrates state-of-the-art technological and scientific capabilities with existing European upstream services, complies with guidelines provided by the Emergency Response Core Services Interdisciplinary Group, and is linked to existing Core Services, including SAFER and GMES EMERGENCY. DORIS goes beyond the state-of-the-art technologies used to detect, map, monitor and forecast ground deformations. DORIS uses the unique ERS-1/2 and ENVISAT C-band SAR archives to provide unprecedented, very long time-series of ground deformations. DORIS evaluates new SAR sensors, including ALOS, COSMO-SkyMed and TERRASAR-X, exploiting the different bands (L/X), the significantly reduced revisiting time, and the higher spatial resolution offered by these sensors. DORIS moves forward the integration of satellite and ground-based SAR interferometry, coupled with GPS measurements and geophysical probing. DORIS exploits multi-spectral images to map ground deformations, to identify the elements at risk, and for dynamic risk scenarios design. Finally, DORIS investigates the possibility of using thermal images for the assessment of landslide susceptibility and hazard. DORIS will be tested in six study areas in Europe. Successful application of the service in these areas guarantees that the downstream service will work in Europe. DORIS will provide a business model for long term self-sustainability of the service; the project is proposed by a unique team of public administrations,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European tropical forest research network (etfrn) (phase 3)' in the context of a Fifth Framework call.

assistant: **Objectives**

Good proposals for tropical forest research submitted by joint research teams of EU and Developing Country Scientist by responding to relevant calls. Coordinated EU researchers' response to European Commission policy initiatives and demands through Q&A service, and through thematic meetings. Concerns and priorities for tropical forest research brought to the attention of EC staff. Information on EU tropical forest research disseminated through publications, Email, the ETFRN website and meetings, leading to impaction policy and management of tropical forest and tree resources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The NAtive Seed Science, TEchnology and Conservation Initial Training Network' (NASSTEC).

assistant: **Innovation**

NASSTEC will train 11 Early Stage Researchers and 1 Experienced Researcher in native seed science, conservation and use, so that environmental mitigation and adaptation projects can have increased impact. Without immediate enhancement of capacity and capability in this specific area of biodiversity science, the native seed industry in Europe will fail to develop towards the multi-million dollar markets of the US and Australia. NASSTEC plans to interconnect the public and private sector through the establishment of a multidisciplinary European doctoral ‘school’ with the aim of integrating knowledge in plant ecology, genetics, molecular biology, taxonomy, ecology, conservation, seed biology, environmental science, agricultural botany, crop science, breeding and horticulture. This knowledge will be transferred to industry, thereby contributing to the EU bio-economy. NASSTEC includes 7 full (FP) and 7 associated partners (AP) from 4 EU Member States. It interconnects 4 different sectors: private companies (3 FP and 2 AP), NGOs (2 AP), public land governance bodies and academic institutions (4 FP and 3 AP). The scientific and training programmes embrace 12 research topics, clustered under three sub programmes: A) In situ seed sampling; B) Seed biology characterisation; and C) Production and deployment of seed. Critically, the findings from the three sub-programmes will be interconnected, integrated and communicated rapidly and effectively to the ESRs/ER and all external stakeholders through a global e-Learning Environment (ELE). This ELE will be pivotal in delivering a balanced scheme of exchange visits and secondments, a rich programme of network events, news of network achievements and research information; including the findings of the final NASSTEC conference. NASSTEC wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced devices for the Reduction of CArbon DIoxide and Artificial photosynthesis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ARCADIA project will focus on building artificial photosynthetic devices (or photoelectrochemical cells), with the aim of producing alternative fuels exploiting renewable energy sources (namely sunlight). The key strategy will involve the development of photoelectrodes able to perform the water oxidation (at the anode) and the carbon dioxide reduction (at the cathode), and their further assembly in a standalone set-up (i.e. requiring no other energy source, but sunlight). Thus, ARCADIA will contribute to the abatement of the atmospheric anthropogenic emissions of the greenhouse gas CO2 by its exploitation as a renewable carbon feedstock to obtain clean fuels and value-added chemicals as the target products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Characterisation of major Ralstonia solanacearum type III pathogenicity Determinants' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The discovery of type III secretion systems during the last decade has dramatically changed our understanding of the molecular basis of bacterial pathogenicity. Type III secretion systems are conserved in animal and plant bacterial pathogens and are involved in the delivery of bacterial effector proteins into the host cells. In plants, the identification of bacterial effectors is of an outstanding importance, since the understanding of the molecular processes leading to disease development and the identification of the corresponding molecular targets in the eukaryotic cell opens the way to new biotechnological strategies for crop protection.In the plant pathogen R. solanacearum biochemical and genetic approaches led to the identification of several proteins that are exported through the Type III apparatus. The advent of the genome sequencing projects has facilitated the identification of new effectors based on the similarity or the structural features of predicted proteins, as well as the coregulation with th e Type III secretion system. A group of related genes that are called the awr family and have no similarities in the databases has been identified through analysis of R. solanacearum genome sequence. Mutation of one awr gene dramatically decreases R. solana cearum aggressivity on tomato, which renders the AWR proteins excellent candidates as effector proteins that carry out a function within the plant cell.The aim of this project is to characterise thoroughly this gene family in search for type III-dependent effectors with a major role in pathogenicity. The process will include:1) demonstration of protein translocation into plant cells,2) study of their expression profile and analysis of the mutant phenotype regarding pathogenicity,3) subcellular localisati on of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The Role of novel PKC Kinases in Integrin Activation'.

assistant: **Innovation**

Integrins represent a family of cell adhesion receptors mediating cell interaction with the extracellular matrix ligands. Their ligand-binding activity is tightly regulated and, when defective, gives rise to thrombosis or inflammation and contributes to cancer progression. To date, the key steps of integrin activation in response to both extracellular and intracellular signals are well described, however, the counteracting processes resulting in receptor inactivation remain incompletely understood. The host laboratory has pioneered research in this area by screening to identify integrin inactivating proteins involved in neuronal disorders, cell migration and cancer. Although the novel subfamily of protein kinase C (nPKC) has emerged from these screens as putative integrin inhibitors, the role of these kinases in regulation of integrin-mediated signalling remains to be investigated. Benefiting from my strong methodological proficiency in protein kinase research and the host laboratory's extensive expertise in integrin biology in cancer, I aim to address the role of nPKCs in regulation of integrin activation from both mechanistic and pre-clinical points of view. I expect to identify new cancer relevant signalling nodes by executing mechanistic in vitro studies with specifically engineered kinase mutants, state-of-the art cancer cell biology and imaging, followed by in vivo pre-clinical cancer studies in cancer models and patient sample cohorts. The result of this innovative and interdisciplinary project will represent a valuable basis for potential design of drug targeting strategy and therapeutic intervention not only for treatment of cancer, but also of other diseases where nPKCs and integrins are implicated.


**Keywords:** Integrin regulation, Protein kinase C, Cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards a comparative sociology of beauty The transnational modelling industry and the social shaping of beauty standards in six European countries' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project studies how beauty standards - perceptions of physical beauty in women and men - are socially shaped. It will focus on the transnational modelling industry, an institution centrally concerned with the production and dissemination of beauty standards. The project aims to develop a comparative sociology of beauty. By comparing beauty standards both within and across nations, it will identify central mechanisms and institutions through which such standards are developed and disseminated. In 4 subprojects this study investigates 1. How standards of female and male beauty are perceived, shaped, and disseminated by professionals in the transnational modelling field; 2. How female and male models perceive, represent and embody beauty standards in their work; 3. How female and male beauty has been portrayed by models in mainstream and high fashion magazines from 1980 till 2010; 4. How people of different backgrounds perceive female and male beauty, and how their beauty standards are related to the images disseminated in modelling. Each project will be done in France, Italy, the Netherlands, Poland, Turkey and the UK. This project is innovative in several ways. It is the first comprehensive study of the social shaping of beauty standards. The 4 subprojects will result in an extensive account of production, products, and reception of a contested cultural industry. Moreover, this project draws together in novel ways theories about media, cultural production and taste formation; gender and the body; and globalization. The project will make a major contribution to the study of globalization: it studies a transnational cultural industry, and its comparative and longitudinal design allows us to gauge the impact of globalization in different contexts. Finally, the project