RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of New Genetic Determinants of Plasma Fibrinogen Concentration' (INDEFIC) targeting Seventh Framework.

assistant: **Abstract**

The proposed project aims at the identification and characterization of novel genes, genetic variants and pathways implicated in the regulation of plasma fibrinogen concentration, which is an independent risk factor for cardiovascular disease (CVD). Several genome-wide linkage and association studies have identified some interesting regions which may contain candidate genes that are not yet identified. Despite this exciting progress in narrowing down genomic regions that may be linked to plasma fibrinogen concentration, very few of these signals have actually been dissected to the final causative gene that is responsible for disease susceptibility, and in most instances, the allelic variants and the biological mechanisms underlying these signals remain unknown. Thus, our first and main objective is to dissect already defined candidate regions to identify attractive novel candidate genes and variants that explain variation in plasma fibrinogen concentration. Specifically, we will exploit the novel “expression QTL” methodology as our main tool to prioritize candidate genes in previously described chromosomal regions associated with plasma fibrinogen concentration. This new strategy allows the identification of transcriptional regulatory loci without any prior knowledge of the regulatory mechanism and is now gaining increasing attention as a powerful tool to understand the molecular networks in which candidate genes operate and how changes in these networks lead to changes in disease traits. Accordingly, we expect that it may reveal important novel information about the mechanisms and biological pathways by which some genetic variants may affect plasma fibrinogen regulation. The identification of genes, genetic variants and pathways that influence plasma fibrinogen concent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The CIVIS Alliance Programme for International, Interdisciplinary, Intersectoral Research and Training for Experienced Researchers' under Horizon 2020.

assistant: **Concept**

CIVIS3i is an international programme open to Experienced researchers (ERs) from all around the world, developed in the context of the European University CIVIS. Aix-Marseille Université (France) has set up the programme which gathers the 8 universities of European University CIVIS and 24 non-academic partners. CIVIS3i aims to offer talented researchers an attractive environment for research, and train a future generation of employable, mobile, first-class researchers, able to conducted a high-level research  - interdisciplinary and intersectoral - on five important global societal challenges: Health; Climate, Environment, Energy; Digital and Technological Transformation; Cities, Territories and mobilities; Society, Culture, Heritage. CIVIS3i will award 24-month postdoctoral fellowships to 32 Experienced Researchers (ERs), through two calls for applications open during the 50 months of the programme following an exemplary selection process following the key European principles set out in the Code of Conduct for the Recruitment of Researchers. CIVIS3i is rooted in the concept of a cross-border environment for research that offers a wide range of possibilities in terms of collaboration, whether international, interdisciplinary or intersectoral. The 32 research projects set up in CIVIS3i will meet requirements in terms of international, interdisciplinary and intersectoral dimensions and a mandatory three-month secondment to an academic or non-academic organisation. The participation  of multiple non-academic partners to CIVIS3i will guarantee the intersectoral support to collaborative and innovative research projects with a bottom-up approach. A comprehensive training and networking programme is proposed by CIVIS3i to the fellows integrating interdisciplinarity and interse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Renormalisation Group methods for discrete Quantum Gravity' (RGDQG).

assistant: **Concept**

Understanding quantum gravity requires us to bridge a large gap of scales. The fundamental theory we are searching for is a theory of spacetime at the shortest distances and highest energies. There are many competing proposals for what type of structure best describes this regime. We can not currently generate these high energies in the lab, and hence the most likely method of observing quantum gravity effects are large scale, i.e. astronomical and cosmological observations. To make phenomenological predictions for these large structures, from short scale quantum gravity models, we need to use a renormalisation procedure.In solid state physics, it is common to use real space renormalisation, in which systems at different sizes are directly related. An example of this is block spin renormalisation of the Ising model, by summarising several spins into one block the system is rescaled, leading to an effective description at larger scales. Applying a similar blocking renormalisation to discrete theories of quantum gravity can help us understand their scaling behaviour. This scaling behaviour can then be used to generalise from small scale simulations to larger scale structures, and to identify universal characteristics arising in these models.I have much experience in working with discrete gravity systems, using both analytic and computational methods, which the research and training covered in this proposal will allow me to extend.The host institution, Radboud University in Nijmegen, was chosen for the excellent quality of research. The quantum gravity group led by Professor Loll will provide expert advice, and the strong program of visitors will further enrich the project. The mathematical physics group is comprised of experts in the field of non-commutative geometry, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '(IN)FORMING CONFLICT PREVENTION, RESPONSE AND RESOLUTION:THE ROLE OF MEDIA IN VIOLENT CONFLICT' under Seventh Framework.

assistant: **Concept**

INFOCORE focuses on the conditions that bring about different media roles in the cycle of conflict and peace building. It generates knowledge on (1) the social processes underlying the production of conflict news, and (2) the inherent dynamics of conflict news contents, (3) in a systematically comparative fashion. Based on this perspective, we identify the conditions under which media play specific constructive or destructive roles in preventing, managing, and resolving violent conflict, and building sustainable peace. The project will provide detailed knowledge on the process of conflict news production. Specifically, INFOCORE focuses on interactions between (1) professional journalists (in various media), (2) political actors (including public authorities, military), (3) experts/NGOs (in intelligence, peacekeeping, conflict prevention/resolution, and media assistance), and (4) lay publics (individuals and groups, including economic actors). INFOCORE analyzes these actors’ different roles (as sources/advocates, mediators, and users/audiences) in the production of (1) professional news media, (2) social media, (3) and semi-public intelligence/expert analysis. To assess the roles of media for shaping lay publics’ and political actors’ conflict perceptions and responses to ongoing conflicts, we analyze the dynamics of conflict news content over time. We identify recurrent patterns of information diffusion and the polarization/consolidation of specific frames and determine the main contextual factors that influence the roles media play in conflict and peace building. Specifically, we assess the roles of individual agendas and resources, professional norms, media organizations and systems, political systems, and characteristics of the conflict situation. INFOCORE implements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'WATER AND ENERGY ADVANCED MANAGEMENT FOR IRRIGATION' (WEAM4I) under Seventh Framework.

assistant: **Objectives**

Agriculture sector is accountable for 30% of the total water consumption in Europe, but reaches up to 70% of total water consumption in several European southern countries. In recent years, most of the efforts have been focused on water efficiency, without taking care of energy aspects, resulting in some cases on a significant increase in energy consumption, both per irrigated surface and per volume unit of water. The WEAM4i project will mainly address 2 of the priorities of the EIP on Water: “Water-Energy nexus” and “Decision support systems (DSS) and monitoring”. The WEAM4i proposal is based on two innovative management concepts:1. A water&energy smart grid for irrigation: allowing interactive energy use decisions, by introducing demand-side management and matching the consumption to the available energy offer, due to existing water storage capability (in reservoirs or in the soil) that enables an ”near-almost elastic” demand.2. An innovative, cloud based, integration approach: an ICT platform based on a Service Oriented Architecture, for hosting the DSS applications, while, at field level, the existing local irrigation systems will remain.Techniques for resource efficiency at local level will be demonstrated on the irrigation systems aforementioned: for saving water, for improving the m3/kwh ratio and for the minimisation of the operational cost of water supply infrastructures. Full-scale demonstration activities will be performed in 3 EU countries (PT, ES and DE), covering a wide range of landscapes and crop types, from southern to central EU. Companies and SMEs will benefit from the future commercialization of the outcomes while the users will reduce the operational costs of their irrigation systems. To Sum up: once important water savings have been achieved, the n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mucin binding to bioactive molecules: physiological role and new biomaterials' in the context of a Seventh Framework call.

assistant: **Objectives**

Mucins are high molecular weight glycoproteins, responsible for most of the extraordinary properties of the mucosal layer, which covers around 300 m2 of our body’s surface. Mucins have mostly been studied in the context of their physiological role:  for their ability to protect the epithelial layer from viral and bacterial infection, oxidative degradation, dehydration and mechanical stresses. They are also of major importance in cancer biology, where altered mucin secretions are recognized as cancer markers. A few studies have focused on the interactions of “objects” expected to diffuse from the exterior to the interior of the body through mucin gels, such as nutrients, antibodies, viruses and bacteria.This proposal describes how we will study the ability of mucin to sequester bioactive molecules secreted by cells surrounded by mucin. The goal is to investigate whether mucin gels can be a reservoir for bioactive molecules in a similar fashion to what the extracellular matrix is now recognized to be. The proposal describes a three-phase approach, which will both advance our knowledge on the physiological role of mucin gels and will lead to the development of innovative mucin-based biomaterials for drug delivery and tissue engineering applications.The first phase will focus on using 2D mucin coatings to study mucin interactions with relevant bioactive molecules. Also, structure/function will be investigated by modifying mucin chemistry. During the second phase, we will build multilayer thin films of hundreds of nanometer thick using lectin proteins as cross-linker between the mucin layers.  The films will be characterized and their ability to act as a reservoir for drugs and other bioactive molecules will be assessed. Finally, in the return phase, we will combine the retu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conservation of Ancient Stone Quarry Landscapes in theEastern Mediterranean' under Sixth Framework.

assistant: **Concept**

The cultural heritage of the Eastern Mediterranean is predominantly made from stone, and throughout antiquity thousands of smaller and larger quarries were opened. The archaeological record in the quarries comprises rare evidence of stone extraction sites, roads, harbours, settlements, ceramics and inscriptions, which collectively constitute an ?ancient quarry landscape?. Such landscapes are of crucial importance, not only to our understanding of the lives of the non-elite, but of the political and ideolog ical ambitions of an elite that drove resource exploitation to such heights. Yet, as heritage sites of such enormous historical importance these have largely gone unrecognised, mainly due to poor documentation, which has consequently led to their current i ndiscriminate destruction from actions such as modern development and quarrying. The QuarryScapes project will enhance cultural heritage management of ancient quarry landscapes through the development of methodology and conservation models that can be effe ctively implemented in a range cultural contexts. ?Quarryscapes? will develop scientific and practical methodologies for documentation, characterisation and conservation of ancient quarry landscapes, raise awareness of the significance and vulnerability of such sites and contribute to legal protection measures and sustainable management of ancient quarry landscapes. Through case studies in Egypt, Jordan and Turkey, the project will address development of theoretical and practical methods pertaining to the m ajor steps in the process of conservation: from recognition, investigation and assessment of significance, to understanding the risks, developing sound conservation and monitoring concepts, and suggesting mechanisms for sustainable management. QuarryScapes will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In the Roadmap for Mental Health and Wellbeing Research in Europe (ROAMER), top-priority is research into child and adolescent mental health symptoms. CAPICE (Childhood and Adolescence Psychopathology: unravelling the complex etiology by a large Interdisciplinary Collaboration in Europe) will address this priority. This network will elaborate on the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, a well-established collaboration of the many European birth and adolescent population based (twin and family) cohorts with unique longitudinal information on lifestyle, family environment, health, and emotional and behavioral problems. Phenotypic and genome-wide genotypic data are available for over 60,000 children, in addition to genome-wide genotypes for over 20,000 mothers and epigenome-wide data for over 6,000 children. Combined with the enormous progress in methodology, the results of the research performed in this network will greatly expand our knowledge regarding the etiology of mental health symptoms in children and adolescents and shed light on possible targets for prevention and intervention, e.g. by drug target validation. Moreover, it will provide Early Stage Researchers (ESRs) with an excellent training in the psychiatric genomics field given by a multidisciplinary team of eminent scientists from the academic and non-academic sector highly experienced in e.g., gene-environment interaction and covariation analyses, (epi)genome-wide association studies, Mendelian Randomization (MR) and polygenic analyses. With a focus on common and debilitating problems in childhood and adolescence, including depression, anxiety and Attention Deficit Hyperactivity Disorder, CAPICE will contribute to improving later outcomes of young people in European countries with c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Impact of Prenatal Stress on BRAIN AGEing' (BRAINAGE) under Seventh Framework.

assistant: **Objectives**

Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions.Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests.Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Next-Generation Natural Language Generation'.

assistant: **Objectives**

This project aims to overcome the major hurdles that prevent current state-of-the-art models for natural language generation (NLG) from real-world deployment.While deep learning and neural networks brought considerable progress in many areas of natural language processing, neural approaches to NLG remain confined to experimental use and production NLG systems are handcrafted. The reason for this is that despite the very natural and fluent outputs of recent neural systems, neural NLG still has major drawbacks: (1) the behavior of the systems is not transparent and hard to control (the internal representation is implicit), which leads to incorrect or even harmful outputs, (2) the models require a lot of training data and processing power do not generalize well, and are mostly English-only. On the other hand, handcrafted models are safe, transparent and fast, but produce less fluent outputs and are expensive to adapt to new languages and domains (topics). As a result, usefulness of NLG models in general is limited. In addition, current methods for automatic evaluation of NLG outputs are unreliable, hampering system development.The main aims of this project, directly addressing the above drawbacks, are:1) Develop new approaches for NLG that combine neural approaches with explicit symbolic semantic representations, thus allowing greater control over the outputs and explicit logical inferences over the data.2) Introduce approaches to model compression and adaptation to make models easily portable across domains and languages.3) Develop reliable neural-symbolic approaches for evaluation of NLG systems.We will test our approaches on multiple NLG applications—data-to-text generation (e.g., weather or sports reports), summarization, and dialogue response generation. For example,