RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identifying neuronal or muscle cell-specific suppressors that rescue motility defects in the ALS model of the nematode worm Caenorhabditis elegans' to be submitted under Horizon 2020.

assistant: **Abstract**

Amyotrophic lateral sclerosis (ALS) is a fatal disease that progressively causes loss of neuronal and muscle function, for which there is no known cure. Although the genetic causes of ALS vary, the cytoplasmic accumulation of the TDP-43 protein in neurons is highly consistent among patients. Thus, TDP-43 is believed to be a point of convergence in the pathway responsible for ALS progression. However, while many genetic and cellular mechanisms have been linked to ALS, there is still a lack of understanding of the neuro-muscular interactions in ALS. In this project, we will identify neuronal or muscle cell-specific suppressors of motor impairment using an ALS model in the nematode worm Caenorhabditis elegans. In this model, transgenic C. elegans overexpress TDP-43 in the neurons, resulting in severe motility defects. We will use optogenetic tools to excite neurons and muscle cells separately in the C. elegans ALS model, contributing to our understanding of how TDP-43 accumulation affects tissue function. In addition, live in vivo microscopy of C. elegans will help us to elucidate the impact of TDP-43 on neuro-muscular interactions over time. Furthermore, novel automated tracking of the nematode worms enables high-throughput analysis of C. elegans mobility. Thus, we can efficiently analyse mobility when TDP-43 is overexpressed, and use this tracking for high-throughput screening of mutants that rescue the ALS phenotype. Once we have identified the mutants that Rescue Motility Defects (RescueMoDe), we will characterize their impact on neuronal and muscular function. Therefore, it will be possible to analyse the tissue-specific role of these candidates, and how they fit into the progression of TDP-43 toxicity in this system. Overall, we aim to further the understanding of AL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Large area synthetic fused silica photomask substrates for 0.18 micron CMOS-technology' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To develop and evaluate 6x 6" substrates for 0.35 um processing.To develop and evaluate 7"x 7" substrates for 0.35 and 0.25 um processing taking into account material resistance to 248 nm excimer laser radiation damage.To develop equipment and technology for large area substrates (9"x 9"), which includes process steps like melting, squaring, slicing, lapping, polishing and cleaning.To develop large area substrate material which is resistant to radiation damage at 193 nm exposure wavelength (for 0.18 um technologies and beyond).At present photomask substrates are produced by Japanese suppliers only, who also dominate the photomask blank market. LAPS aims to establish a European source of substrates and blanks, which meet the requirements of 193 nm excimer laser exposure, 0.18 um technology level, and 300 mm wafer size."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CATALYSIS IN AQUEOUS SOLUTION BY MAGNETIC INDUCTION: BIOMASS VALORIZATION' (BIOCATMAG).

assistant: **Concept**

Within a worldwide upsurge of renewable energies and the need to replace chemicals from fossil sources, BIOCATMAG intends to offer a new catalytic approach for producing chemicals from biomass. Based on magnetically induced catalysis, where a catalyst with a magnetic response combines heating and catalytic functions under an alternate magnetic field, the technology presented would enable the coupling of intermittent renewable energies with biomass valorization. Remarkably, several challenges, but also opportunities, lie on the horizon owing to the use of magnetocatalysis. Some of them would be tuning the selectivity by changing the magnetic field amplitude, stabilizing magnetic metal nanoparticles in water or the need to accomplish cascade-type processes. Therefore, the project aims to broaden current knowledge of magnetically induced catalysis while providing a set of chemicals using unprecedented non-noble metal catalysts and greener reaction conditions, such as aqueous media and low pressures. Furthermore, the reactions have been carefully chosen to cover the main areas of interest in biomass valorization by heterogeneous catalysis. In that sense, the transformation of a next-generation platform molecule (levoglucosenone), the production of organonitrogen chemicals (pyrazines), and the valorization of cellulose will be the processes selected. This selection also considers the need to meet the challenges mentioned earlier. In that line, all reactions will be performed in aqueous media, the levoglucosenone hydrogenation or hydrogenolysis will be adjusted with the field amplitude, and, for the valorization of cellulose, a two-step one-pot process to 2,5-bis-hydroxymethylfurane is proposed. In this last case, a multicatalytic batch reactor working with two different temp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Welfare State in a Complex World Taxes and Benefits in a Diverse Society' (WSCWTBDS), addressing dissemination and exploitation.

assistant: **Impact**

Empirical studies of labour supply at the microeconomic level describe a diverse society with heterogeneous agents and stress the importance of the participation decision, to work or not to work. The aim of this project is to improve our knowledge of the properties of the optimal tax and benefit systems in the extensive model in the presence of heterogeneity.The proposal has a theoretical part and an empirical part. The theoretical part deals with four applications of the extensive model: (1) family benefits and the interaction between household transfers and income taxes; (2) fraud and tax evasion; (3) indirect taxes; (4) dynamic aspects, such as capital taxation and the life-cycle. The empirical part is based on microeconomic data sets. It is made of three different projects: (1) how much of the difference in the number of hours worked in France, the UK and the USA can be assigned to differences in the tax and benefit structure of these countries?; (2)  the role of taxes and benefits in the participation decisions of United Kingdom couples, 1979-2008; (3) pensions, savings, and the decision to retire in the United Kingdom.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Geographic diversity of Neandertals in Europe'.

assistant: **Concept**

Neandertals lived in Eurasia for more than 200,000 years and represent the closest relatives of present-day humans. Their study helps us understand what makes modern humans so unique and evolutionary successful. In this project we will provide new data on Neandertal biological and behavioural diversity in Europe, with the hypothesis that their geographic expansion resulted in a regional differentiation of the populations. First, we will assess biological distance between four geographic groups through the analysis of skeletal discrete traits (anatomical variations), which are good indicators of population history but have never been comprehensively analysed on Neandertals. Our scoring procedure includes a novel approach using Computed-Tomography image analysis. Second, we will investigate Neandertal territorial strategies using strontium isotope analysis in teeth. This is a very new field of research, that applies state-of-the art biogeochemial techniques for obtaining information on movements of past humans. We believe that our synthetic approach that combines morphological and behavioural data, in comparison with results of recent paleogenetic studies, will help reveal insights on Neandertal evolutionary history. This project will allow the candidate to expand her scientific knowledge and to acquire new skills in CT-scan imaging and Geographic Information System analysis. Other training events, such as the co-organization of an international workshop, will enhance her leadership abilities and international visibility. The host organization in Madrid includes recognized experts on Neandertal studies and CT-scan imaging. This project will develop a new field of research in Europe and help build a network between several European countries linked by a common heritage, Ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Real Researchers for Real meetings' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Promoting cross and complementary projects, Real Researchers for Real meetings (RRRM) part of a dynamic coaching and preparation of meetings between researchers and the public at the European event of 23 September 2011 favoring atmosphere of conviviality and exhange.11 partners, including universities, science centers, associations, located throughout the country, from East to West, from North to South have been working on a common project in the desire to give a better exposure to the Researchers’ nightIt will build on the skills of mediators, designers implementing features unique to the specific venue and audience expected. The devices chosen should enable researchers to disconnect from their work environment.Researchers will be put in a situation of dialogue, sharing and exchange with citizens. Upstream work will present their demonstration, the specific focus and to facilitate the meeting as the focus of events.Priority should be given in this approach features highlighting the human person and how to approach his craft at the expense of handling and animations that may conflict with the very purpose of the event, namely to amend the representation citizens of the researchers. ""A job coaching and complementarity may be conducted with artists in a dynamic view of a put, a fresh perspective on science.These approaches must be part of the pathways of the event and its programming leading visitors through a process of questioning the role of the researcher in our societies, and conversely how researchers articulate their jobs in our societies.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fire Detection and Suppression Simulation' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives and content The ban of production of Chlorofluorocarbons (CFCs) means that alternative methods must be considered for effective suppression and extinguishment of fires in those applications for which CFCs (including halon) are presently the only solution. This programme has been proposed to ensure continued European commitment to the safety of potential halon replacement systems. Investigations are ongoing to find a replacement agent for halon. Water mist, alternative gases and powders are all being considered. All of these potential replacements are significantly different in their operation and behaviour to halon based systems. Current Fire Detection systems in aircraft are quite basic in their operation and present one major drawback. An estimated 95% of all reported warnings are false, and these warnings have a direct effect on the operational cost of an aircraft. This research programme investigates both problems of a replacement agent for halon, and a more reliable and effective detection and control system. This project describes an innovative approach to obtaining an environmentally friendly, cost effective replacement of halon based systems by understanding the characteristics of such fire hazards, development of appropriate software models and by validating the models using actual fire test facilities. The proposal concentrates on water mist as the agent since it is cheap, environmentally friendly and requires no special handling for use. An analysis of the test results will enable the design of an improved control and detection system to be performed which will be capable of using the agent more effectively and economically, and thus containing the fire without a major release of the agent. In addition, certification of fire detection systems are b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HD-DittoGraph: a digital human Embryonic Stem Cell platform for Huntington's repeats'.

assistant: **Objectives**

This proposal is aimed at identifying the molecular mechanisms that have brought the human Huntington Disease-causing Huntingtin (Htt) exon 1, with its pure and unstable CAG repeat, to be shaped the way it is today. Specifically, we intend to screen for genetic elements affecting Htt repeat length instability in dividing and postmitotic neuronal cells. The novelty of our approach relies on the construction of a human embryonic stem (hES) cell platform that couples highly efficient CRISPR/Cas9 technology with genome-wide screenings and third generation sequencing, to test the contribution of thousands of unequivocally barcoded cis and trans modifiers on Htt exon 1 repeats instability. In Aim 1, we will test the contribution of cis-modifiers to repeat instability during multiple mitotic divisions, by generating a hES cell platform where we will subsequently introduce a barcoded donor library of different Htt exon 1 constructs, with different CAG and flanking sequences, at the Htt locus. In Aim 2 our hES cell platform will be implemented with inducible Cas9 elements and sgRNAs libraries to perform genome-wide loss and gain of function (LOF, GOF) screenings of trans-acting modifiers of repeat sequence and size. The sgRNAs will act as barcodes for the modifier genes, allowing to test their causative role on repeat size changes. In Aim 3, we will exploit the neurogenic potential of hES cells in our LOF and GOF platforms to identify Htt exon 1 repeat modifiers in differentiating striatal neurons. Candidate modifier genes will be individually validated and tested for their functional impact on gene networks by transcriptome analysis. In all approaches, third generation sequencing and ad hoc computational pipelines will allow the simultaneous identification of the repeat changes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Technology for treatment and recycling of the water used to wash olives'.

assistant: **Objectives**

Scientific objectives and approach:The present project aims to create an affordable and compact system capable of recovering and recycling the majority of the drinkable water used in the washing of the olives. The proposed treatment for recycling the most part of the water will follow three basic steps:- Preliminary aerobic treatment: the treatment will be conveniently implemented before the ultrafiltration unit (or integrated with the ultrafiltration unit in the same apparatus), in order to reduce the content of the organic compounds.- Ultrafiltration: this stage purifies the waste stream from all of the suspended solids. A factor of volumetric concentration of 10 is foreseen; removal of 100% of the suspended solids and colloids, of 33% of COD, of 50% of the fatty substances. Turbidity of the filtrated liquid <1 NTU is also expected.- Reverse Osmosis: for the concentration of saline and organic components that were passed into the permeate in first stage and that are found in solution.The total treatment will allow for the procurement of:- Drinkable water, to be used again for the washing of olives in loco (more than 90% of the residual is expected to be recycled)- A relatively small amount of a polluting solution (i.e. with high concentration of pollutants and with the characteristics of vegetation water), to be sent to disposal mixed with vegetation water.The UDOR project will be structured in 4 phases:- Identification of requirements and definition of specifications, determined by the end-users, by analysing the generic EU producers situation and by characterising samples from different production sites.- Laboratory work on the aerobic treatment, the ultrafiltration and reverse osmosis operations: the three principal steps will be studied in the lab to determine the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Supply chains linking food smes in europe's lagging rural regions.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

SUPPLIERs aims to assist the sustainable development of small food enterprises in lagging rural regions of the EU through the development of new tools and models for supply/distribution chain integrating leaking to improved market accessibility and competitiveness. Food Sees must develop efficient and effective supply chains to contribute fully to the local economy and community. SUPPLIERS will research their business environment, including communications and information technology (Candy IT), and members of there supply chains through to retailers. It will assess the structure, operation, performance and competitiveness of the chains and their contribution to rural development. It will identify the possibilities for improved policies, institutional structures and rural development strategies for food supply chain integration in lagging rural regions of the EU and Poland; and ascertain cost-effective dissemination of good practice in SME food supply chains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone' (SEDiLINK), addressing dissemination and exploitation.

assistant: **Impact**

Monitoring datasets available to evaluate past mining impacts on catchment and coastal environmental quality are severely limited in temporal extent presenting a major hindrance to effective decision making for management of legacy pollution to achieve the goals of the EU Water Framework Directive and Mining Waste Directive. The “Sediment linkage between land, river and sea: evaluating impacts of historic mining on sediment quality in the coastal zone” (SEDiLINK) research project will develop an innovative sedimentological approach to overcome these important challenges and close this substantial knowledge gap. The SEDiLINK approach will bring together established techniques (e.g. Pb-210 geochronology) with new approaches in evaluating riverine ecosystems (e.g. Pb isotope fingerprint) and deliver an integrated toolkit for evaluation of mine waste impacts. The extensive metal mining history of Tamar River Basin and coastal zone, southwest UK, offers an ideal test-bed in which to develop the novel and powerful SEDiLINK approach for wider application in other EU contaminated fluvial and coastal ecosystems requiring longer term remediation legacy pollution.    Through developing this tool, the candidate will gain new scientific and technical skills in cutting edge isotopic fingerprinting techniques working with multidisciplinary and multinational groups in UK and Spain, developing and complementing her previous knowledge in radiotracer applications. This period of advanced training and mobility will underpin maturation and independence as a leading EU researcher.