RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Barrel Assemblies of Membrane Active Artificial Foldamers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important. As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant. For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content. Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs. However, this mechanism is not understood, greatly hindering rational development of similar compounds.My main research goal is to reach insight into the structure-function relationships of the barrel molecular scaffold and to gain understanding of how its ability to protect internal parts from the environment may contribute to toxicity. To approach this problem, I aim to design and study foldamer oligomer assemblies. I hope to define the fundamentals of how peptide - lipid bilayer interactions govern formation of potentially toxic oligomers at a molecular level. This may be exploited for developing new antimicrobial compounds.Foldamers are highly similar to natural peptides in terms of structural diversity, thus they are ideal model systems, in several cases showing antibiotic activity and enzyme resistance. The computationally designed, structures will be studied with experimental methods in model membranes. I have experience with theoretical (QM&MD) and experimental tools (polarized light spectroscopy). However, characterisation of solution phase membrane systems requires use of additional techniques and I aim to learn more into X-ray scattering methods (SAXS,WAXS). In the lab of Prof. Attila Bota, I will have optimal conditions to gain expertise with these. The Host Institute will also provide a professionally organized and equipped e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Glide-symmetric mEtamaterials for iNnovative radIo-frequency commUnication and Sensing (GENIUS)' (GENIUS).

assistant: **Innovation**

GENIUS (Glide-symmetric mEtamaterials for iNnovative radIo-frequency commUnication and Sensing) is an Industrial Doctoral Programme led by top European actors of research and innovation in the field of radio-frequency (RF) systems with applications to aerospace communications and automotive sensing proposing novel scientific tools provided by glide-symmetric (GS) artificial materials (or metamaterials). It has recently been discovered that these metamaterials, characterized by a special symmetry inside their constitutive unit cells, possess marvelous electromagnetic (EM) properties (propagation in an ultra-large bandwidth, strong isolation and high absorption features) capable to address the open challenges of modern RF systems, motivated by the increasing demand of ubiquitous connectivity, and the growing automation of transports.GENIUS aims at training highly skilled and creative researchers capable to propose out-of-the-box solutions to industrial needs by means of their knowledge of physical properties of complex EM systems. The design of devices will be enabled by the development of suitable modelling methods (circuit-based, integral-equation-based, quasi-optical) shedding light on the properties of GS materials and providing fast and reliable data on their behaviour. The inter-sectoral character of the training reflects its inter-disciplinarity content: researchers will benefit of academic expertise in GS metamaterials, of the industrial knowledge of applicative needs and of fabrication and test facilities not commonly found at individual institutions.GENIUS will be the only international training program bringing together metamaterial physics and application-oriented RF design. Its researchers will benefit of a dense network of contacts with scientists acquired d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Widening our knowledge of derivative fullerenes : modelling, synthesis, characterisation and application in donor-acceptor ensembles', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The research objective of the seven-group 'WONDERFULL' Network is the design and construction of large, highly ordered, functional molecular and supramolecular assemblies. To do this we will use and improve our understanding of fullerene derivative chemistry to produce novel, light-driven chemical donor-acceptor ensembles. They will be engineered for optimal properties in non-linear optics and photo- conversion applications. We will capitalize on the known electron-accepting properties of the bare fullerene cages, and their enhancement by suitable fictionalization. Achievement of the target requires a Research Training Network that has multi-disciplinary input from teams working across the spectrum of chemistry, physics and materials science. This entails a programme of systematic synthesis of novel modified fullerene derivatives (Trieste, Erlangen), spectroscopic, electrochemical and photophysical measurement, materials fabrication and characterization as films, gels and coatings (Patras, Paris, Vienna), backed up by theory, modeling and molecular design (Bologna, Exeter).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cathodic protection by x-cel technology: durable building technology benefiting elektrochemical methods as a preventive action.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Study of a new technology and process benefiting the combined use of electro-osmosis, cathodic protection and electro-chemistry in order to control detrimental deterioration processes in concrete constructions e.g. corrosion of the reinforcement steel and alkali-silica reaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New silicon neutron detector' under Fourth Framework.

assistant: **Concept**

Europe has a clear world lead m neutron scattering, one of the key microscopic probes of condensed matter. It is important that acces to large scale neutron facilities within Europe is maximised by improving both the quality and quantity of their instrumentation. The objects of this proposal are to: . train a young scientist in the techniques of neutron instrumentation . improve neutron detector technology . improve the instrumentation of European neutron facilities It will achieve these objectives by using the expertise that Dr. Schooneveld has developed in Si detector technology and applying it to the development of new neutron detectors. The availability of large-area low-cost semiconductor Si devices offers new opportunities for innovative designs that will be both effective and buildable at low cost. Such an innovation would enable very significant improvements to be made to European neutron instrumentation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The integration of local motion signals in the human visual system' (1994-1998).

assistant: **Innovation**

Research objectives and content In the visual areas of the human brain, motion within the visual image is initially encoded locally. At each point in the image, measures are obtained in parallel at different spatial scales (from fine details to coarse spatial structure). It is not known at what stage local signals are combined across the image to produce an integrated percept (global motion). The objective is to establish whether this integration across the image occurs before or after signals are integrated across spatial scales. This fundamental question will be addressed in three different experimental contexts, using objective measures of the visual performance of human observers. The experiments are expected to provide a definitive answer to the question. Training content (objective, benefit and expected impact) Working at the host institution would give me the opportunity to deepen my knowledge of the visual system. I would acquire high-level skills which should put me in a strong position to establish myself as a postdoctoral scientist, either in Germany, where research on this field is making an increasing contribution, or in other European countries. Links with industry / industrial relevance (22) Research on human vision provides knowledge of the visual information processing capabilities of the brain. This provides essential groundwork for the development of machine vision systems (e.g. robots). Knowledge of the limitations of human vision is important in the design of visual display systems (e.g. in aircraft).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'DEVELOPMENT OF A PROTON-ELECTRON DOUBLE-RESONANCE IMAGING (PEDRI) INSTRUMENTFOR RADIO FREQUENCY IMAGING OF FREE RADICALS IN WHOLE RATS AND COMPARISON WITH FOURIER-TRANSFORM ELECTRON-PARAMAGNETIC-RESONANCE (FT-EPR) IMAGING'.

assistant: **Innovation**

Research objectives and content This project is concerned with the development of a radio frequency Proton-Electron Double-Resonance Imaging (PEDRI) instrument. PEDRI is a technique that combines nuclear magnetic resonance imaging with electron paramagnetic resonance (EPR) in order to image free radicals in living animals. The project will investigate the potential combination of PEDRI technique with radio frequency Fourier-Transform (FT) EPR imaging. To this purpose optimal coil designs and active damping methods will be studied to simultaneously optimise the requirements for PEDRI and FT-EPR resonators. In field-cycled PEDRI the applied magnetic field is switched between two levels during the imaging pulse sequence, with the EPR irradiation being applied at very low field and the NMR detection taking place at higher field. This increase the PEDRI sensitivity and reduce the radio frequency power deposition in the sample. Low-inductance gradient coils for field-cycled PEDRI techniques will be designed, and integrated with a multipolar magnet that operates at about 100 Gauss. A direct comparison between PEDRI and FT-EPR imaging will be made in terms of sensitivity/resolution/acquisition time. The main aim is to study the optimal designs and experimental conditions for in vivo detection of free radicals. Training content (objective, benefit and expected impact) All research in PEDRI is currently based in Europe with active groups in Aberdeen, Delft, and Strasbourg. The complementary technique of EPR imaging also has a strong European research base in L'Aquila, Surrey, Leicester. The Applicant, Dr. Alecci, has worked in the research group in L'Aquila, directed by Prof. A. Sotgiu, since 1987. The Applicant was the recipient of two Marie Curie Fellowships (HCM Programme, 199
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms and functions of receptor-like kinase (RLK) negative regulation in plant development' (RLK) under Seventh Framework.

assistant: **Objectives**

In plants, receptor-like kinases (RLKs) form the largest family of membrane receptors (>400) and they are involved in virtually all aspects of the plant life cycle, including development, immunity and reproduction. Although a few model RLKs, such as the steroid receptor BRI1, have been studied extensively, there are still many with unknown function. Besides, we still know very little on how those receptors are activated. Notably, the functions and mechanisms of RLK negative regulation have virtually not been addressed, while it is established that receptor inhibition play a critical role in signaling and diseases in metazoan. During my postdoctoral work, I characterized a negative regulator of BRI1 called BKI1 (for BRI1 KINASE INHIBITOR) and identified a small family of related proteins of unknown function, called MAKRs for MEMBRANE ASSOCIATED KINASE REGULATORs. Preliminary results suggest that some MAKR proteins regulate BRI1, while others control different developmental pathways, possibly regulated by unknown RLKs. Here we propose to combine biochemistry, genetic and cell biology to address the mechanisms by which BKI1/MAKRs regulate RLK activity and to identify the developmental pathways and receptors targeted by the MAKR proteins. This work should unravel the functions of RLK negative regulation as well as identify new receptor kinase involved in plant development. Altogether, our studies will provide mechanistic insight into receptor kinase signaling pathways in plant and their evolutionary relationship to well-studied mammalian systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Finite temperature field theory on the light-cone' under Sixth Framework.

assistant: **Concept**

This proposal includes a two-year stay at SLAC under the supervision of Prof. S. Brodsky and a subsequent stay at the University of Wales, where the scientist in charge will be Dr. S. Dalley. Both are leading experts in quantum field theories on the light -cone. Light-cone quantization provides an elegant and promising method for solving the outstanding problems in quantum field theories like e.g. bound states and phase transitions in QCD.An approach to finite temperature field theory on the light-cone was developed by F. Lenz and the researcher and is based on the correspondence between relativistic field theories at finite temperature and finite extension. In the outgoing phase the researcher will start her investigation of finite temperature field theory on the light-cone with a study of screening effects in Abelian QED plasmas and the quark gluon plasma. Afterwards the researcher will go on studying non-perturbative issues such as the computation of parton distributions at finite temperature. In the ret urn phase, her skills acquired and new insights into finite temperature field theory on the light-cone, gained during the outgoing phase shall be applied in the context of numerical calculations in finite temperature field theories on a transverse lattice. The existing supposition that a light-cone lattice might be applicable at low temperature and large density will be investigated. The verification of this possibility would offer the opportunity to study the whole phase diagram of QCD numerically.The phase structure of QCD is investigated in heavy ion collisions performed at RHIC (later at CERN and GSI). The researcher will enhance her diversity in the field and adopt important complementary and specialist skills during the fellowship to develop an independent rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Environment for the development and distribution of open source software' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Open source distribution editors package and assemble a large number of programs and applications into a single tested distribution, together with a set of tools to install and administer the system.Two key functions are:- Producing a new version of a distribution: for this the editor starts from a complete version of the distribution, it add and delete packages, refreshes packages with more recent versions, reconfigure packages, etc.- Customizing a distribution for a specific user: this user can be a corporate user wanting a specific distribution for its needs, a hardware or a software vendor. Customization includes adding, deleting packages, updating and configuring packages. The main objective will be to develop technology and tools to support and improve these two processes.Our goal is to dramatically increase the team productivity. We will do this by addressing three problems: The current way distribution edition is done is as follows: a complete copy of the current state of the software is available at the central site of the editor. This data is then mirrored on a set of mirrors in a hierarchical although crude and inconsistent fashion. The mirroring problem can be solved through various methods, coming either distributed database technology or from peer-to-peer approaches. We will propose specific tools and mechanisms to solve the problem, provide an implementation and the analysis of the impact of our solution.Packagers collect packages manually over the Web, then build and maintain the dependency data, This manual process will be, partially at least, automated. Packages are delivered from the outside with various levels of tests, test should be partially done outside, in many cases only the package developer is able to really test, and should do it. Tools and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optical control of CaMKII signaling' in the context of a Horizon 2020 call.

assistant: **Objectives**

How are memories formed and stored in the brain? One candidate mechanism is long term potentiation (LTP), a form of synaptic plasticity that is characterized by strengthening of synaptic connections between neurons in the brain, lasting from minutes to hours. The first step in LTP is a sharp influx of calcium ions, which serves to activate many Ca2+-dependent proteins, one of which is Calcium-calmodulin-dependent protein kinase II (CaMKII). Once activated, CaMKII translocates to the post-synapse, and phosphorylates numerous substrate responsible for LTP induction. Curiously, CaMKII also has a role in specifying cellular structure by bundling actin. After activation, CaMKII activity apparently becomes Ca2+-independent, and can last for hours after the initial stimulation. This property of CaMKII lead the researchers to propose that CaMKII, in addition to induction of LTP, could also be responsible for LTP maintenance and hence memory storage. I propose to study the role of CaMKII in both the induction and maintenance of LTP in neurons. For this purpose, I plan to generate variants of CaMKII that can be acutely controlled by light. Using the tools I develop, I will investigate the interplay between CaMKII function and structure with respect to LTP and other neuronal processes. This approach offers unprecedented molecular, spatial and temporal control over CaMKII activity in neurons, allowing a better understanding of its involvement in learning and memory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Systematic dissection of molecular machines and neural circuits coordinating C. elegans aggregation behaviour'.

assistant: **Objectives**

Elucidating how neural circuits coordinate behaviour, and how molecules underpin the properties of individual neurons are major goals of neuroscience.  Optogenetics and neural imaging combined with the powerful genetics and well-described nervous system of C. elegans offer special opportunities to address these questions. Previously, we identified a series of sensory neurons that modulate aggregation of C. elegans.  These include neurons that respond to O2, CO2, noxious cues, satiety state, and pheromones. We propose to take our analysis to the next level by dissecting how, in mechanistic molecular terms, these distributed inputs modify the activity of populations of interneurons and motoneurons to coordinate group formation.   Our strategy is to develop new, highly parallel approaches to replace the traditional piecemeal analysis.We propose to:1) Harness next generation sequencing (NGS) to forward genetics, rapidly to identify a molecular ¿parts list¿ for aggregation.  Much of the genetics has been done: we have identified almost 200 mutations that inhibit or enhance aggregation but otherwise show no overt phenotype.  A pilot study of 50 of these mutations suggests they identify dozens of genes not previously implicated in aggregation.  NGS will allow us to molecularly identify these genes in a few months, providing multiple entry points to study molecular and circuitry mechanisms for behaviour.2) Develop new methods to image the activity of populations of neurons in immobilized and freely moving animals, using genetically encoded indicators such as the calcium sensor cameleon and the voltage indicator mermaid.This will be the first time a complex behaviour has been dissected in this way.  We expect to identify novel conserved molecular and circuitry mechanisms.