RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of novel self-assembled Nano-Electronics - Towards tunable quantum-mechanical resonance' (INSANE).

assistant: **Concept**

Specially designed functional molecules are the next logical step in the ongoing miniaturization of mechanical, electronic, and opto-electronic devices. The present proposal responds to the necessity of systematic theoretical investigations of interfacial properties of electrode/molecule junctions.Attempting to bridge the ever widening gap between the highly specialized theoretical and experimental communities, it aims at the practical implementation of insights gained by theoretical, quantum-mechanical modeling by incorporating the real-world situation into the simulations and via intensive dialogue and close collaboration with experimental scientists. The main scientific objective of the proposed project is to outline a novel approach toward molecular electronic devices.Our intention is to induce strong electronic coupling of charge-transfer character between noble-metal contacts and covalently attached (self-assembled) molecules, thus integrating molecules and equally nanoscopic metal contacts into one functional unit. This goal is to be achieved by tuning both the molecules and the type, size, and dimensionality of the metal contacts in order to line up the metal Fermi energy with the frontier molecular orbitals and induce quantum-mechanical resonance between the two electronic subsystems.The proposed project links the research fields of theoretical and experimental surface science, nanotechnology, cluster physics, quantum-chemistry, theoretical solid-state physics, and the rich chemistry of functional p-conjugated molecules. The core part of this multidisciplinary, joint theoretical and experimental proposal will be the applicant's computational work.He is to propose suitable systems, to establish a consistent framework of first-principles methods that allows to pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clinical trial of gene therapy with dual AAV vectors for retinitis pigmentosa in patients with Usher syndrome type IB' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Usher syndrome (USH) is  the most common combination of deafness and blindness due to retinitis pigmentosa.  USHIB caused by mutations in the large MYO7A gene, is among the most severe and frequent forms of USH.  While deafness can be improved with cochlear implants, blindness remains untreatable. Retinal gene therapy with AAV vectors is both safe and effective in humans, however it is limited by AAV cargo capacity which would not allow transfer of the large MYO7A expression cassette. UshTher objective is to test the safety and efficacy of a highly innovative gene therapy approach (dual AAV) in the retina of USHIB patients. The projects builds on data previously obtained by the coordinator that a single combined subretinal administration of dual AAV vectors, each packaging one of the two halves of a MYO7A expression cassette, results in MYO7A reconstitution and therapeutic efficacy in a mouse model of USHIB.  This has received the Orphan Drug Designation from the European Medicines Agency. It would be the first time the dual AAV vector approach is tested in humans. Towards this ambitious objective, UshTher has assembled a very competitive consortium with leaders in the fields of retinal gene therapy from bench to bedside including SMEs with expertise in the development of gene therapy products. The planned activities span from manufacturing of clinical –grade dual AAV vectors to non clinical safety, biodistribution and expression studies performed under good laboratory practices up to performing a multicenter, multinational clinical trial which envisages subretinal administrations of dual AAV vectors in twelve USHIB patients. UshTher success will set the basis for a cure for USHIB retinitis pigmentosa, and for testing dual AAV vectors in other rare and more common condi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Algorithms, Digital Platforms and Competition' (DigitalComp), addressing dissemination and exploitation.

assistant: **Impact**

Dealing with challenges associated to digital platforms is currently one of the top three priorities according to the European Commission’s Digital Single Market strategy. Platforms can create immense value for the economy, online commerce  and drive up productivity. But, at the same time, they have been disruptive and source of regulatory controversy. By design, in the core of platforms’ business models there are algorithms which are based on machine learning principles and use personal data as input to match efficiently and at real time supply with demand. This project analyses the dynamic impact of digital platforms on markets and consumers and addresses challenges that are associated with their disruptive operation, using a novel and multi-level economic approach. At the same time, it also explores the impact of algorithmic design and automated systems in decision making, market competition and society. The research agenda is separated in 3 chapters. The first chapter deals with algorithmic competition and evaluates whether big data raise entry barriers and what the incentives of algorithmic systems  to discriminate are. It also assesses policy measures to increase algorithmic transparency and accountability. The second chapter deals with the dynamic nature of digital platforms. A firm with significant market power today might not be in the position to conserve its market power tomorrow because of the entry of, or drastic innovation by competitors. The chapter develops a methodology that defines a robust measure of future potential competition. It also provides insights over the creation and expansion of digital platforms in EU and US and illustrates firms' equilibrium market strategies in fast growing markets. Chapter 3 deals with the impact of automation on employ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improvement of natural resistance in fruit' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

In most climates fruits can only be grown and harvested during a small part of the year. Yet, consumption of fruit, and hence demand occurs throughout the year. For this reason, large parts of the fruit harvests must be stored for more or less extended periods of time before they are sold to the consumers. Obviously, such storage causes considerable losses due to pathogen attack and natural senescence. The traditional solutions to these problems have been storage under controlled or modified atmospheres and the use of synthetic pesticides. Nevertheless, losses exceeding 20% are not uncommon. The 'FRUTA FRESCA' project proposes to develop a remedy both by improved monitoring of fruit quality and by reduction of fruit spoilage through enhancement of natural plant resistance. Our strategy is based on two breakthroughs in basic science, which can now be exploited for the benefit of European agriculture. The first is the identification of components of the natural defense response in plants which can be used not only as early and sensitive indicators for spoilage, but which can also be optimised in order to enhance resistance. The second is the enormous advance in laser technology which makes it now possible to detect natural defense molecules with unprecedented sensitivity, versatility and reliability.  Objective 1 On-line detection by laser techniques of the production of natural plant stresssignal and defense molecules such as ethylene, acetaldehyde, ethane, hexenal.  Objective 2 Exogenous application of natural pesticides and the enhancement of the endogenous concentration of such compounds, to enhance shelf-life of fruit.  This project brings together seven groups, together possessing an extensive experience in all aspects of the project, i.e. The laser technology, plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamic regulation of Ras signaling – a novel way to attenuate PI3K activity in cancer and inflammation' under Seventh Framework.

assistant: **Concept**

Ras genes take a center stage in signal transduction and molecular oncology, where Ras-driven signaling pathways control proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Mutations in RAS are very common in cancer, and have been found in 20-30% of all human tumors. Moreover, constitutive Ras activation is known to trigger senescence in the absence of “second hit” mutations (e.g. loss of p53). Interestingly, both processes - cancer progression and oncogene-induced cellular senescence - were shown to be dependent on Ras interaction with phosphoinositide 3-kinase (PI3K), which points to a dominant role of Ras-mediated PI3K activation in proliferative disease.Here we propose to investigate the possibility that Ras/PI3K interactions are dynamically regulated, which is supported by preliminary data: in certain cellular states, post-translational modification of Ras disrupts its binding to PI3K.We aim to elucidate the importance of this process in physiology and disease. We assume that regulated Ras interactions with PI3Kalpha act in cancer progression, while Ras/PI3Kgamma complexes transiently regulate inflammatory processes. Along these lines, we aim to uncover cellular signaling networks that dynamically dissociate Ras from PI3K. When the above mechanism is validated, we plan to study the consequences of the abrogation of Ras/PI3K interactions in “in vivo” mouse models. These will elucidate if and how PI3K detachment from Ras acts as a a general and central mechanism to balance inflammatory cell recruitment, oncogen-mediated metastasis, proliferation and senescence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Highly sensitive detection of single microwave photons with coherent quantum network of superconducting qubits for searching galactic axions'.

assistant: **Objectives**

Detection of single photons in the microwave range has a number of applications ranging from galactic dark matter axions searches to quantum computing and metrology. We propose a novel approach to acquisition of extremely low energy microwave signals (~1 GHz), based on the general concept of a passive quantum detection.  For such highly sensitive detector (quantum antenna) the key novel concept we intend to use is the coherent quantum network composed of a large amount of strongly interacting superconducting qubits embedded in a low dissipative superconducting resonator. We will fabricate and explore the dynamics of coherent quantum networks based on two types of superconducting qubits: transmons and flux qubits. A spatially distributed network of superconducting qubits interacting off-resonance with the incoming radiation, shows the collective ac Stark effect that can be measured  even in the limit of single photon counting. The interaction of the signal with the collective quantum states occurring in the network of superconducting qubits has the fundamental character of a quantum non-demolition measurement, whereby the quantum states of the signal and the collective states of qubits become gradually entangled. In particular, by employment of the network of large number of qubits (N) and utilization of a collective mode established in the network, we expect to exceed the standard quantum limit and reach the so-called Heisenberg limit of sensitivity which is proportional to 1/N instead of ~1/√N in case of N non directly interacting  qubits.  Assessment of the progress will be done by testing arrays with increasing number of superconducting qubits by using complementary experiments with different single photon sources. The feasibility of the superconducting network detec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Distributed Research Infrastructure for Hydro-Meteorology Study'.

assistant: **Objectives**

In the Lisbon strategy, the 2005 European Council identified knowledge and innovation as the engines of sustainable growth and stated that it is essential to build a fully inclusive information society. In parallel, the World Conference on Disaster Reduction (Hyogo, 2005), defined among its thematic priorities the improvement of international cooperation in hydrometeorology research activities.Hydrometeorological science has made strong progress over the last decade at the European and worldwide level: new modelling tools, post processing methodologies and observational data are available.In principle, a huge amount of hydrometeorological data and information is available for the European region, but enormous scientific and technical obstacles have to be overcome when mining the data.Recent European efforts in developing a platform for e-science, like EGEE (Enabling Grids for E-sciencE), SEE-GRID-SCI (South East Europe -GRID e-Infrastructure for regional e-Science), and the German C3-Grid, provide an ideal basis for the sharing of complex hydrometeorological data sets and tools. Despite these early initiatives, however, the awareness of the potential of the Grid technology as a catalyst for future hydrometeorological research is still low and both the adoption and the exploitation have astonishingly been slow, not only within individual EC member states, but also on a European scale.With this background in mind, the goal of the Distributed Research Infrastructure for Hydro-Meteorology Study (DRIHMS) project is the promotion of the Grid culture within the European hydrometeorological research community through the diffusion of a Grid platform for e-collaboration in this earth science sector: the idea is to further boost European research excellence and competitiveness in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Procedures In Simple Arithmetic:  neural implementation and development' (PISA), addressing dissemination and exploitation.

assistant: **Impact**

More than 20% of 15-year-old European students are low achievers in mathematics. Because low math competence can have dire economic and social effects, improving our knowledge of the neural mechanisms involved in arithmetic processing is critical to inform teaching and reduce low achievement. A central question in math education is whether calculation procedures should be emphasized over strategies based on retrieval during arithmetic learning. To date, studies suggest that calculation is less efficient than retrieval, at least for simple arithmetic problems. For example, problems for which subjects report using procedures are solved slower and less accurately than problems for which retrieval strategies are reported. Procedures are also linked to enhanced activity in fronto-parietal brain regions and this is thought to reflect effortful processing. These studies, however, might be misleading because (i) automatic procedures might be executed so fast that they cannot reach consciousness and (ii) enhanced activity in fronto-parietal regions during effortful calculation might not be related to procedures per se. This project will use functional magnetic resonance imaging (fMRI) to test the hypothesis that fronto-parietal regions may support automatized procedures that can be as efficient as retrieval. Specifically, we will capitalize on the idea that, in problems solved with procedural strategies, abstract automatic procedures should be pre-activated by the simple presentation of an arithmetic sign before the problem itself. First, we will test whether activity in fronto-parietal brain regions can be automatically triggered by the simple visual presentation of an addition sign, and whether this automatic activation may facilitate arithmetic performance in adults proficien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trusted Embedded Computing' to be submitted under Seventh Framework.

assistant: **Abstract**

Trusted Computing (TC) has become meanwhile an established technology for verification and implementation of integrity and security at personal computers. Similar requirements are also needed for embedded computing platforms which have alike trust and security problems due to the increasing complexity and therefore instability of Os and applications as well as connection to the Internet with its security dangers and attacks. Until now the TC standard is mainly targeted for PCs with their large resources of available code space, specific bus interfaces and large computing power which are not available with embedded platforms.As there are a much higher number of embedded computing platforms like PCs in the field, it becomes a necessity to adapt the current TC standard to embedded platforms.The project will make an systematic approach for the development of trusted embedded systems, consisting of hardware platforms with integrated trust components and also work on the necessary trusted operating systems:1.Trusted hardware, Trusted Platform Module as VHDL design, which could adapted to different host systems together with  processors supporting a trust architecture2.Trusted operating systems mainly based on the new virtualisation/hypervisor architecture which are already in use at the PC world. Adapting it to the specific requirements of small platforms and trusted modules3.Security layers for implementing easy accessible security mechanisms.4.Trusted protocols: Elementary TC protocols like TSS (Host interface API) and TNC (trusted network connect, an advanced secure communication protocol) will be adapted for embedded platforms5.Application examples will give us feedback about available trust functionality, application friendliness and user requirements.We will use the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ReducINg the footprint of consumer products through public dialoGUe and innovative bio-based MAterials' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

INGUMA aims to foster the development of bio-based materials and their acceptance by the public by relying on three main values sustainability, inclusion, and aesthetics - the values of the New European Bauhaus.The value of sustainability will be tackled by developing different types of bio-based materials from raw materials derived from agriculture residues and secondary raw materials from wood processing. Various types of materials will be developed: functionalized fibers, insulation material based on mycelium, resin-free insulation material based on wood fibers, bio-based adhesive for plywood, low-formaldehyde plywood board, wooden sandwich panels, and growth media for plants. In addition, these materials will be integrated into insulation panels and vegetated roofs.The sustainability and circularity of these materials and solutions will be ensured by applying environmental criteria and digital tools that will allow users to make decisions on the most sustainable solutions available. Additionally, the materials will be tested according to European and international standards, as a first step in the commercialization outside of Europe (Canada).The value of inclusion will imply the design of co-creation laboratories that encourage collaboration among stakeholders, fostering transparent communication and generating innovative ideas. These labs will provide a platform for engagement and a structured process for stakeholders to contribute their insights and actively participate in the development of bio-based construction materials. This way, the acceptance of the developed materials, products and solutions by end-users and consumers will be maximized.The value of aesthetics will be accomplished by co- designing and constructing a community house prototype in the rooftop