RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Sparing gene therapy for Inherited ROd COne dystrophies'.

assistant: **Objectives**

Many believe that corrective ophthalmology gene therapy is the future for rare diseases such as retinitis pigmentosa (RP), a rare, inherited retinal disorders characterized by diffuse progressive dysfunction of primarily rod photoreceptors, with subsequent degeneration of cone photoreceptors. This degenerative disease causes blindness to young people and adults. But with this kind of therapy only treating 1 out of 65 mutations of the pathology, it means a small group of patents can be targeted.So, what do the remaining 2 million people have as on option?SparingVision have developed an innovative treatment that can stop the evolution of this blindness and we call it RdCVF. The first vision saving treatment of its kind.What makes it different is that in 2004, J Sahel and T Leveillard identified that in RP, the main factor that leads to blindness is a loss of RdCVF with is a neurotrophic factor for the cones (photoreceptor). This means that by a single injection under the retina SparingVision’ product can treat all the genetic forms of RP, potentially treat patients with dry AMD, and provide patients with long lasting efficacy. In SparingVision’ proof of concept the product was injected to mice models provided almost immediate protection and repair to the cones and the evolution to blindness is stopped. Behind this product is a very strong team, a world renamed scientific advisory board. The product development has been secured with strong IP, exclusive licenses agreements and pursue R&D with research collaboration agreements and raised money. So, with the help of SME INSTRUMENT supporting the project SIROCO, SparingVision will be able to finalize the next steps of the clinical validation of an unique therapeutic approach and make the product finally accessible and being t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The potential of CSR to contribute to the implementation and integration of EU strategies' (CORE), addressing dissemination and exploitation.

assistant: **Impact**

In recent years the EU has committed itself to some core strategies to shape the Europe's future, mainly the Lisbon strategy, the sustainability strategy and the integration of an enlarged Union.These strategies can only be successful if their implementation involves adequately and effectively economic actors, non-profit partnerships and networks, stakeholders, local communities and civil society.In this setting, Corporate Social Responsibility (CSR) holds the potential to stimulate corporate contribution s to the implementation and integration of the mentioned EU strategies. CSR may thus contribute to make the EU the most dynamic and competitive knowledge-based economy in the world. CORE devises the organisation of a coherent series of four conferences targeted to young researchers and aimed to investigate the potential contribution of CSR to implement and integrate EU strategies.The first three Conferences focus on the sustainability strategy, the Lisbon strategy and EU enlargement, respectively. The fourth and last Conference tackles the question of whether CSR can promote the necessary integration of the three strategies.The CORE Conferences represent a unique opportunity for young researchers to learn about the potential of CSR in an interdisciplinary and stimulating setting. A different range of multidisciplinary competencies and professional experiences is gathered with the intent to provide highly qualified training on a research topic of large European interest.In terms of training capacity, the conferences are structured as to guarantee a lively and constructive exchange of knowledge from experienced researchers and professionals to young researchers, through a structure that favours continuous interactions and debate (i.e. panel sessions, knowledge-building s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Trade-offs in immunity in the metal hyperaccumulator Noccaea caerulescens' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Metal hyperaccumulating plants are able to accumulate exceptionally high concentrations of metals, such as Zinc, Nickel, and Cadmium, in their shoots to levels that would be toxic to most other plant species. The trait of metal hyperaccumulation has evolved independently multiple times in the plant kingdom. Since this trait is of high importance to bioremediation and biofortification strategies, intensive research efforts aim to decipher the underlying molecular processes. However, although our understanding of the molecular mechanisms involved in metal uptake and tolerance has improved, not much is known about the processes that have led to the evolution of metal hyperaccumulation in plants. Recent studies have provided new insight into the ecological and evolutionary significance of this trait by showing that the metal hyperaccumulating plant Noccaea caerulescens can use high concentrations of accumulated metals to defend itself against attack by pathogenic microorganisms. Interestingly, infected N. caerulescens plants show none of the inducible defence responses that are used by most plants to provide protection against infection, which suggests that it relies on accumulated metal for disease resistance. The fact that these plants have evolved the ability to uptake and store metals in their shoot tissue, but have in turn lost defences common to most plants suggests a trade-off in expressing both traits. This project aims to study the evolutionary, ecological and functional processes involved in the gain of metal hyperaccumulation and loss of other defensive traits in N. caerulescens. Responsible genes will be identified using phenotyping and RNAseq technology and these candidate genes will be further analysed through evolutionary approaches. The project will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RNA silencing in regulation and evolution' under Seventh Framework.

assistant: **Concept**

Small RNA is a specificity determinant of silencing mechanisms that can target RNA through base pairing to affect RNA stability and translation. This targeting process, directly or indirectly, can also target DNA and chromatin to introduce epigenetic modifications. In plants there are many   hundreds of thousands - of different small silencing RNAs (sRNAs) produced from many thousands of loci. These sRNAs have enormous potential to influence genetic and epigenetic regulation because, from analysis of transgenes, it is clear that RNA silencing can have diverse effects. There can be RNA-mediated signalling between cells and complex interaction networks of RNA molecules with positive feedback and amplification loops.  In addition there can be epigenetic effects that, once induced, can persist between generations.  In REVOLUTION the aim is to find out which of the endogenous sRNAs have the various RNA silencing properties revealed by transgenes. The aim is then to integrate these findings into a systems level understanding of regulation and evolution in Arabidopsis. The role of these sRNA systems will be investigated in plants subjected to hormone and stress treatments. We shall also investigate the role of these sRNAs in natural variation between genotypes of plant and their effect in hybrids between these plants. In the final stages of the work it is intended to explore the various effects of endogenous sRNAs in plants other than Arabidopsis including tomato.  This work will provide a new level of understanding of the mechanisms affecting gene expression in plants. This fundamental new understanding will affect crop science through conventional breeding and genetic engineering. In addition because RNA silencing takes place in animals including vertebrates there will be re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated Urban transport concepts and market orientated urban transport systems/on demand urban transport systems.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The goals are to provide new knowledge on the integration of the different actors involved in urban transport management systems (local authorities, public transport operators, regional authorities, etc.), including market oriented urban transport systems, and to develop a conceptual methodology for assessing the integration of these actors. The project emphasis is on non-technological issues: strategic, organizational, institutional, legal and financial. Although the Consortium does not plan to develop any new technology, the support that existing or emerging technologies can provide to the integration of the different urban actors will be studied. These goals will be achieved through the following detailed and measurable objectives:1. To review current status of integrated urban transport management systems. Special attention will also be paid to concepts, tools and techniques developed in other EU Programmes, as Thermie and the Telematics Applications Programme.2. To develop strategies and concepts for co-ordinating the various actors and operators, with special attention to urban traffic control, interurban traffic control and public transport.3. To develop a methodology which will allow the different urban actors (local authorities, public transport operators, regional authorities, user groups, technology providers, etc.) to assess the level of integration of their urban centre.4. To provide a set of guidelines for the harmonization of the information provided to car drivers and passengers and the allocation of tasks corresponding to the different information providers. %Athens (GR), Brescia (IT), Kuusankoski (FI), Toulouse (FR), Valencia (ES), London (UK). %INTRAMUROS is linked with MOTIF. In addition, links with other projects, also from the Telematics Applicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Biological agents that actively attack Cultural Heritage stoneworks' in the context of a Seventh Framework call.

assistant: **Objectives**

There is a social and political need to protect and preserve European Cultural Heritage (CH). Outdoor CH stoneworks can be damaged by physical and chemical processes including deterioration processes caused by microorganisms. To effectively protect and maintain long-term conservation of European CH stonework, it is vital to identify the active components of the microbial community that cause the most damage in the biodeterioration processes and define their specific roles. Research in this area has been initially limited to the use of cultivation studies. More recently, in the last decade, research through the application of cultural-independent molecular methods focused on the structural analysis of the microbial community, detection of specific microbial agents, and identification of microorganisms present in the environments where biodeterioration occurs, have been carried out. But only few studies have been performed for the detection of metabolically active components in the biodeterioration processes in prehistoric paintings in caves. Therefore the proposed project is innovative in the CH field, and it focuses on the identification of the active “key players” in the biodeterioration processes and on the understanding of their function and activity. The project will use the most advanced techniques in the microbial molecular ecology including Whole Genome Amplification, 16S rRNA gene, functional gene and RNA analyses to investigate the active components of the microbial community colonising outdoor CH stoneworks. The project has a multidisciplinary approach, based on microbiology, molecular biology, and biogeochemistry linking in-situ with lab-chamber based studies to assess the development and population dynamics of microbial communities on stone. This multidiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'BRINGING THE PLASTIC WASTE TRANSFORMATION BY THE INSECTS AT SCALE' under Horizon Europe.

assistant: **Concept**

The traditional linear plastic industry business model results in an ever-growing amount of accumulated waste which contributes significantly to the negative environmental impact of the global plastic industry. One of the biggest issues concerning the recycling of used polymeric materials, packaging, textile, furniture, is the handling of complex waste streams consisting of mixtures, co-polymers, and other recalcitrant materials, such as thermosets (non-melting plastics, foams), that can be only burned or disposed of on the landfills. Yet, neither of these solutions is acceptable from the environmental point of view, therefore the new regulations and EU directives aim to limit these methods.We have developed a novel approach towards handling of complex plastic waste streams, where there is no available recycling alternative, thanks to under patent technologies. The approach is based on one specific insect, Galleria mellonella, the greater wax moth, and we have developed a scalable vertical farming process that enables the insects to digest and transform polymeric materials into proteins, lipids and biofertilizers. The long-term goal of this developed process is an environmentally-sound and commercially-successful transformation facility.WINSCALE focuses on the scaling up of the transformation process. Namely, it focuses on the biochemical and technological development of the solution applied to two specifically difficult waste streams: sludge coming from the waste treating companies and polyurethane foam coming from matrass recycling facilities.WINSCALE enables the overall improvement of the investor readiness of the developed solution, contributes to the creation of new, cross-sectoral value chains of waste transformation to added value products, thus promoting Europea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cities as mobility hubs: tackling social exclusion through ‘smart’ citizen engagement' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The SMARTDEST project tackles the societal challenge of social inclusion and sustainability in European cities by developing innovative solutions in the face of the conflicts and externalities that are emerging as a result of new forms of ‘mobile dwelling’. These encompass the rising cost of living, housing shortages, congestion of public services, the dislocation and marginalisation of low-income workers, and the transformation of place identities; all factors that point at avenues of exclusion of the most vulnerable sectors of resident communities. Faced with this, SMARTDEST’s overarching aim is to contribute towards urban policy agendas which take tourism and its social effects seriously. Its ambition is to fill a knowledge gap about the effects of tourism mobilities on urban inclusion and cohesion, and about the contextual, political and technological factors that determine fundamental variations in such effects; and to explore, design and test the validity of potential innovative pathways to mitigate social exclusion. The project thus includes 4 research packages that respectively (1) analyse tourism mobilities and mobile dwelling as transformative force-fields for places; (2) excavate social exclusion issues and coping practices through the engagement with affected communities in case study cities; (3) develop CityLabs as sites for the  design of people-based and place-based solutions (both in the digital and non-digital realm) which demonstrate value for the broad ‘destination ecosystem’ of case study cities, and scale up as innovative systems of governance; (4) transfer the insights gained by the project at local level and extend their impacts through a dialogue with policy entities, concern communities, innovators and scientists throughout the EU policy space.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MariTech Talent Programme' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The MariTech Talent will develop a twin transition INTRApreneurship skills development programme, bringing maritime industry professionals and innovative enterprises with concrete digital solutions together in a two-way learning experience. The programme will provide:-   Necessary twin skills for the maritime workforce-   Support to deep tech solutions providers developing key technologies for unlocking the twin transition in the maritime industry Thе MariTech Talent programme will apply a challenge-based INTRApreneurship model which will nurture learning by working on the most pressing needs identified by the ports and maritime companies themselves. Teams consisting of current workers and deep tech startups, scaleups and SMEs will work together to apply concrete solutions, undergoing the necessary training on the way. On the one hand the programme will secure the required skill set for the maritime workforce related to the green and digital transition. They will acquire operational knowledge in key digital domains enablers of the twin transition in the maritime industry such as machine learning and data analysis for predictive maintenance,  energy management systems, system integration, automation, remote operation,  cybersecurity and e-navigation through direct collaboration with deep tech solution providers. On the other, it will provide valuable insights and feedback on the relevance and effectiveness of the applied digital solutions. As a final result, maritime companies and ports will gain in-depth insights into the benefits digital solutions can bring to their operations, while at the same time their employees will become skilled and confident in their use.


**Keywords:** twin skills,  green and digital transition,  upskilling,  maritime industry,  deep tech tal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The analysis of paired fin development in the zebrafish' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The vertebrate limb constitutes a classic model for the study of developmental processes. Since it comprises a non-vital part of the embryo body, the limb bud can be readily manipulated without affecting survival. In addition, many molecular events that occur during limb development are also present in other embryonic regions; in this way, knowledge acquired from the analysis of limb formation can be used to interpret developmental processes elsewhere. The vertebrate limb originates as a small bud of undifferentiated mesenchymal cells covered by an ectodermal cap, which protrudes from the embryonic trunk. How this group of cells begins to proliferate and starts taking shape into a highly organized structure has long been the subject of research among dev elopmental biologists. Over the past years, grafting experiments on avian and amphibian models, combined with over-expression studies performed in chick and null mutant analysis in the mouse, have contributed to elucidating some of the molecular pathways t hat pattern the limb. However, many questions concerning limb outgrowth initiation and the establishment and maintenance of the signalling centres patterning the limb bud still remain unsolved. More recently, the zebra fish has become a third important model organisms for limb development, since its paired fins are homologous to tetrapod limbs. The development of novel tools, enabling the combination of both gain- and loss-of-function approaches including genetic and embryological manipulation of the embryo and the generation of large scale mutagenesis makes the zebra fish an attractive model system for limb development. Using the zebra fish, this project aims to gain further insight into the signalling cascades leading to limb initiation. In addition, mapping and cha