RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Single cell profiling of X chromosome reactivation during primordial germ cell specification in vivo' (XPGCS).

assistant: **Innovation**

In female mice, one of the two X chromosomes is inactivated during early development to ensure dosage compensation between genders. A long non-coding gene, Xist, plays a crucial role in the initiation of the X chromosome inactivation (XCI) process. Primordial germ cells (PGCs), the precursors of sperm and eggs, transmit genetic and epigenetic information to subsequent generations, following extensive reprogramming, erasure of methylation and genomic imprints, and X chromosome reactivation. The inactive X (Xi) then undergoes progressive reprogramming and reactivation in the germline of female embryos, through the loss of Xist RNA coating, followed by the erasure of the repressive H3K27me3 histone mark, and eventually biallelic expression of X-linked genes.Although the global dynamics of Xi reactivation have been mapped little is known about the gene-specific dynamics, or the mechanisms involved. To explore gene activity on the entire X chromosome during reprogramming in the germline, I will perform single-cell transcriptome analyses on PGCs from C57BL/6 X Castaneus F1 female hybrid embryos. The high rate of sequence polymorphisms between these strains provides allele-specific information for the activity of the Xp (paternal X) and the Xm (maternal X). I will investigate the kinetics of Xp and Xm gene reactivation chromosome-wide at the single cell level following PGC specification. Furthermore, I will study the dynamics of the expression of X-linked genes in conjunction with chromatin changes in PGCs by monitoring the loss of H3K27me3 enrichment on the inactive X chromosome. In parallel, I will study how the regulation of H3K27me3 affect Xi reactivation by using a conditional mutant mouse model of a H3K27me3 demethylase, UTX. Altogether, the innovative and multidisciplin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extremal Problems in Fourier Analysis and Applications' in the context of a Sixth Framework call.

assistant: **Objectives**

We plan to explore systematically a number of closely related problems, using recent techniques of Fourier analysis. Key topics are positive definite functions, uncertainty principles, and duality theory in, say, locally compact groups. Wide interest in an d current flourishing of Fourier analysis and in particular extremal problems stem from applications, ranging even to far fields of science, from mathematical areas as number theory, geometry and analysis, to applied mathematics including numerical analysi s, finite fast Fourier transforms and information theory, etc. Addressing concrete problems, we expect the results being useful also in signal processing, phase reconstruction, electric circuits, crystallography, coding, antenna design, radar engineering. We plan basic, fundamental research, but the work has also an interdisciplinary character, centered on applications in mathematics, physics and engineering. We will publish results in acknowledged international research journals. The project helps the res earcher to draw from his wide, strong background in mathematical analysis when focusing his work. It provides him intensive training from a distinguished French school of Fourier analysis, but also integrate him into activities of the respective European n etwork HARP, including continuation of existing collaboration with Fourier analysts from other branches. Moreover, the project aims at providing the scientific elevation of the researcher's work to allow him achieving the highest scientific degree at his b ase, in Hungary. That should help him to consolidate a new, strong research team in Hungary, where forming of a Fourier analysis group has already started. Members of the group, in particular young scientists, are planned to be involved considerably into t he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Imaginative Narratives and Scenarios for Inspiring Restoration and Innovation for European Seas and Water Systems' (INSPIRI), addressing dissemination and exploitation.

assistant: **Impact**

Progress toward the European Green Deal, the Mission Restore Our Ocean and Waters, and related EU climate, biodiversity, and pollution targets is hindered by governance barriers such as mistrust among decision-makers, lack of public support, and modest policy action. Building on creative participatory methods, the INSPIRI project will contribute to overcoming these challenges. The inclusive INSPIRI consortium will innovate by engaging with a wide range of stakeholders to imagine aspirational futures for EU waters using the Nature Futures Framework. Through case studies across the four Mission Lighthouse regions, we will co-create visions of desirable futures for ocean and water systems with stakeholders. Aligned with key EU strategic objectives and targets, these will then become goals for back-casting and modelling regional scenarios. The outputs from both visioning and modelling exercises will serve as inputs into regional Transformation Labs that bring together decision and policy-makers, experts and other stakeholders from the Lighthouse regions to chart actions towards implementing sustainable futures for EU waters. We will develop innovative scientific and artistic visualizations in each case study as well as at the pan-European level for both 2030 and 2050 time-horizons. Finally, through a creative, multi-layered communication, dissemination, and exploitation strategy, leveraging the full potential of art-science collaboration for motivating change, we will inspire key target groups to take meaningful action. Our consortium, collaborating closely with the Mission Lighthouses and governance structures, brings together world-class expertise in stakeholder engagement, visioning, modelling, policy analysis, and art-science collaborations to ensure we can deliver on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Legal Governmentality - governing climate activism through criminal law and human rights in Europe' (LeGo).

assistant: **Innovation**

Since 2018, the European climate movement has embraced civil disobedience to denounce government inaction on climate mitigation. Governments increasingly respond with criminalization of climate civil disobedience, while NGOs, activists and transnational institutions (e.g. Amnesty Intl., the UN) defend it. Criminalization and defense of civil disobedience highlight a growing tension between state efforts to restrict political protests (often by treating protests as a matter of security), and transnational efforts to legitimize protests (usually treating them as a matter of rights). LeGo advances our understanding of criminalization and rights-based defense of climate civil disobedience in the UK (common law system) and in Germany (civil law system). Both countries are at the center of a growing repression of climate civil disobedience. To date, there is little understanding of how criminalization and defense of climate civil disobedience affect activists and the climate movement. The main research objective is to examine how the use of criminal law and human rights discourses shapes the legal consciousness and conduct of climate activists. To this end, the project examines criminal trials against climate activists; state efforts to pass new laws and mobilize criminal codes and security frames to prosecute activists; efforts of transnational actors and institutions to counter criminalization; and climate activists’ perceptions of and responses to criminalization and rights-based defense. LeGo adopts a mixed method approach drawing on methods and concepts from political and legal anthropology and geography, social movements and mobilization studies, and critical legal studies. Theoretically, the project advances our understanding of how environmental activism is governed t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.' to be submitted under Horizon 2020.

assistant: **Abstract**

INPACT aims at the pre-clinical development of innovative drugs and drug formulations against selected cancers (eg prostate cancer) and pathogenic bacteria (eg S. aureus). The INPACT consortium allies the expertise of both academic and industrial R&D partners that contribute with their own unique technologies to achieve new drugs that are only possible to develop in an integrative effort. Academic partners have unique knowledge and technologies on supercharged viral proteins-derived cell-penetrating peptides (eg from Dengue virus) and ultra-resistant cyclic peptides that may be transferred to the industrial partners, which in turn have specialized proprietary technologies on anticancer and/or peptide drugs’ technologies. The judicious exchange of knowledge among partners will lead to new resistant peptides for trans-barrier delivery of drugs (eg cyclic peptide-drug chimeras) and bacterial killing (both planktonic and biofilms). INPACT includes four leading academic partners (from Portugal, Spain, Australia, and Brazil) and three consolidated biotech SMEs (one from Portugal and two Spain).In addition to the R&D project itself, INPACT involves at the highest possible level a top business school in Europe (IESE, Barcelona, Spain), a consolidated media partner specialised in science communication (Ciencia Hoje, Rio de Janeiro, Brazil) and experts in international science funding from one of the top US universities (University of Stanford). The consortium will be the perfect environment for young researchers to acquire knowledge and skills in science, technology, entrepreneurship, business, and communication so they can pro-actively tailor their career path in a life-long learning perspective. This is a contribution towards the advancement of Europe through the use of resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a high speed, recyclable packaging technology for yellow fat food products' under Fourth Framework.

assistant: **Concept**

Of the 19,500 injection moulding companies in Europe, around 75% are SMEs. However the packaging market for yellow fat food products, such as margarine, butter, yoghurts and pate tends to be dominated by larger, often American owned, companies using thermoforming technology to produce round or rectangular tubs with foil sealing membranes and simple 2 or 3 colour, off line ink printed, motifs around the outside. Around 90% of the market is currently serviced by this technology. The remaining 10% is split between two in-mould labelling, injection moulding systems. One system uses special purpose printed film between 80 Microns and 40 microns, as the decoration media. The other uses much cheaper 30 micron film, commonly used in high volume food packaging applications such as crisp packets and snack wrappers. Both injection moulded techniques have a price premium of around between 15% and 25%, which has prevented mass take up of the technology within its potential markets, even though there are significant product benefits offered by the injection moulded version. The industrial objective of the proposed RTD is to provide European food packaging sectors with an in-mould decorated, injection moulded packaging technology that has the following advantages over the existing thermoformed products, but at a price that is within 5% of that offered by the existing technology; - A full colour, high resolution print capability for the package exterior. - A complete decoration coverage over all five sides of the package's base. - An integrated tamper evident lid-base interface. 100% recyclability . - A 50% reduction in set up times for new motifs, reducing price penalties for shorter runs. - The potential of gas barriers to the package, through an additional laminate on the printed fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Generalization to the theory of d-modules of the characteristic cauchy problem' (1994-1998).

assistant: **Concept**

AMS Calcification Numbers: 14F05, 32C38, 35A27, 58G07. Key words and phrases: D-modules, characteristic Cauchy problem, sheaves on manifolds. Objective of the project: Generalization of the notion of asymptotic developpement for the solutions of the characteristic Cauchy problem to the framework of D-modules (i.e. generalized over determined systems). Approach: Algebraic analysis. Methods already developed in my earlier studies with Prof. P. Schapira. State of the art most important reference: L. Garding, T. Kotake, J. Leray, Uniformisation et diveloppement asymptotique de la solution du problhme de Cauchy liniaire ` donnies holomorphes; analogie avec la thiorie des ondes asymptotiques et approchies, Bull. Soc. math. France, 92, 1964, 263361.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synergy packing approach for energy optimised building renovation' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The project aims to demonstrate a new approach for renovation projects, the so-called synergy package approach, by renovating 600 dwellings in DE, NL, BE and DK. The synergy package approach is an innovative method to arrive at a multi-parameter optimum by comparing synergy packages, which are feasible combinations of renovation measures like advanced insulation, improved windows, efficient heating systems, renewable energies, heat recovery from ventilation air etc. The optimum is an achievable combination of CO2 reduction and costs. In the projects up to 70 % of the heat consumption will be reduced.Additionally the project is - to explore the acceptance of investors and users - to increase awareness among housing associations, architects and planners on the possible energy savings using the synergy package approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Probabilistic And Statistical methods for Cosmological AppLications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This is an interdisciplinary project at the interface between Mathematical Statistics, Probability and Cosmological Applications. The principal focus is on the harmonic analysis for isotropic, mean square continuous spherical random fields, with a view to applications to Cosmic Microwave Background radiation data analysis. We will focus in particular on the following issues:1) the characterizations of isotropy in harmonic space, the analysis of higher order polyspectra and their applications to non-Gaussianity analysis;2)  the constructions of spherical needlets/wavelets and their stochastic properties;3) the analysis of random sections of spin fiber bundles on the sphere, as motivated by the analysis of CMB polarization and weak gravitational lensing4) adaptive density estimation for directional data, as motivated by Cosmic Rays data analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterizing the Occipital Oscillatory Activity in Blindness' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The massive reorganization of the occipital regions as a consequence of lack of vision represents one of the mostremarkable examples of the plastic potentialities of the human brain. Despite the large amount of neuroimaging evidenceproving the involvement of occipital areas of blind individuals in non‐visual input processing, the functional role of thissensory reorganized region is still matter of intense debate. In COcOAB, we will use an underexploited neuroimagingtechnique in this field, magnetoencephalography (MEG), in order to study the oscillatory profile of ensembles of occipitalneurons and their brain‐wide functional interaction patterns in blind individuals. This will allow us to gather unprecedentedinformation about the functional relevance of non‐visual activity in the occipital cortex of blind individuals. Moreover,COcOAB will assess the impact of age onset and duration of visual deprivation on the occipital oscillatory activity, thusproviding insights into the relationship between blindness and sensitive periods of maturation in the visual system. Thegroundbreaking potentials of COcOAB reside in the application of the MEG technique to the study of two experimentaldomains — sensory illusions and stimulation at threshold — that has been so far neglected in the field of sensorydeprivation. COcOAB represents a unique testing ground to address how specific regions support perception in amechanistic fashion in visually deprived individuals, thus challenging the current knowledge on the functionality of thesereorganized regions via a highly innovative approach.


**Keywords:** Crossmodal plasticity, blindness, multisensory integration, magnetoencephalography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Space-borne observations for detecting and forecasting sea ice cover extremes' (SPICES).

assistant: **Concept**

The main objective of this proposal is to develop new methods to retrieve sea ice parameters from existing (and imminent) satellite sensors to provide enhanced products for polar operators and prediction systems, specifically addressing extreme and unexpected conditions. Automatic remote sensing products traditionally provide general information on sea ice conditions such as ice extent and concentration. However, for ice charting, tactical navigation and management of off-shore activities much more important is to know and avoid hazardous sea ice conditions. In general, sea ice hazards are related to sea ice thickness. More often than not polar ships and off-shore platforms are only operating during summer seasons and certain regions. This is because they are designed to resist typical forces of induced by pack ice, but they are not designed to resist the extreme sea ice conditions. Ongoing climate warming has manifested as shrinking and thinning of pack ice in the Arctic. This is a primary driver for the increasing shipping, oil and gas explorations and mining activities in the Arctic. However, severe sea ice conditions still exist and in consequence many locations are impossible for ship based operations. Moreover, year-to-year variability of sea ice is very large and hazardous multiyear ice (MYI) floes sometimes appear also in typically seasonally ice free regions.In order to response needs of increase polar activities, we propose to focus on detection of sea ice extremes and automatic production of “sea ice warnings” products. In particular, we aim for a detection of MYI floes in a area composed mostly first-year ice from synthetic aperture radar (SAR), heavily ridged ice regions from SAR, the thickest ice from radar altimeter (RA) thickness profiles, regional anoma