RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Amphiphilic Peptoids as General Tool for Membrane Proteins Stabilization and Crystallization' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

“Pro-Membrane” is an extensive project which has been structured to face multiple tasks of different levels of innovation and risk. In its longest-term and most ambitious goal, Pro-Membrane, aims to face the still not solved challenge of stabilize and crystallize Membrane-Proteins (MPs). This study will use, as innovative tool, well-ordered and disordered functionalizable amphiphilic peptoids  for structural determinations.  Peptoids could indeed succeed where other classes of molecules previously failed, answering to the pressing need of a new method able to establish the specific interactions to stabilize and crystallize each MP. Their peculiar nature helps them to easily cross the membrane and their modular synthesis give access to an infinite combination of molecules. Despite their interest, a systematic and comparative study of their physical properties and self-assembly capacity was never done before. The multidisciplinarity of this work, between Organic Chemistry, Biophysics, and Structural Biology will be achieved through a strict collaboration between all the participants. Training through research and implementation activities have been planned to maximize the candidate’s profile in order to support his career perspectives.


**Keywords:** Membrane Proteins,  Amphiphilic Peptoids,  Conformational analysis,  Thermodynamics of hydrophobic interactions,  Detergents & Surfactants,  Structural studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanism of centrosome positioning in HeLa cells' to be submitted under Seventh Framework.

assistant: **Abstract**

The Centrosome (CS) is an organelle located near the nucleus that constitutes the primary Microtubule Organization Center (MTOC) in animal cells. The distribution of the microtubule cytoskeleton is therefore determined by the localization of the CS. Localization of this organelle is important for many cellular processes: I) Cell shape and polarization[6], II) Cell migration and III) Cell cycle.The processes underlying CS localization are mechanical, with two possible scenarios: I) Pushing forces may be generated at the tips of MTs growing from the centrosome against an object such an organelle, cell cortex or plasma membrane; II) Pulling forces may be generated by MTs that remain attach to the CS and their tips shrink against an object. Alternatively, force could be generated along the length or tip of MTs by motor proteins and may be transmitted to the CS. Both pushing and pulling forces have been demonstrated to play a role in different organisms, but how the net force on the CS is regulated in order to achieve proper positioning is still an important open question.The aim of this project is to study CS positioning in HeLa cells. We will first determine if the dominant force involved in centrosome positioning is pushing or pulling and secondly, explore the different contributions of these forces. To achieve this goal, we will directly perturb the force balance on the CS by severing MTs with laser ablation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design of Hybrid Nanostructured Bio-photocatalyst for Their Application in Bio-photoelectrochemical Hydrogen Production' under Seventh Framework.

assistant: **Concept**

The need to establish renewable energy supplies, both as a strategic economic requirement and as a wedge against climate change is leading organizations to invest in research on capturing solar energy. There is particular interest in artificial photosynthesis, using photons to produce electricity or fuels using a man-made device rather than a plant. In natural in-vitro system for hydrogen production, complex molecule i.e. chlorophyll harvest solar energy and subsequent electronic excitation leads to ejection of electrons from the chlorophyll dimer and then passed on to various electron-transferring mediators. This electron donor system may be replaced with the visible light sensitized inorganic photocatalyst. At present, the photocatalysts that have been synthesized and tested fall far short of the efficiency and catalytic rates of enzymes that catalyze either H2 production (hydrogenases) or O2 production (the Mn cofactor of Photosystem II). Therefore the enzymes themselves represent important benchmarks for gauging the possibilities for building water-splitting photocatalysts from inorganic and organic photophysical materials. In such devices enzyme molecules are linked to the semiconductor surface in such a way that they are stable and electrocatalytically active. Therefore, the proposed project is focused on the fabrication of chalcogenide semiconducting nanostructures (mainly nanotubes / nanowire / gyroid having few nm thick wall) and grafting of redox proteins onto these nanostructures for their subsequent exploitation in photoelectrochemical hydrogen production. The exploration of the photoelectrochemistry involved and properties of enzymes which govern the hydrogen generation will also be undertaken. In addition, various other parameters such as the electrolyte p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Partial migration: individual causes and population genetic consequences' under Seventh Framework.

assistant: **Concept**

Partial migration, where only part of a population migrates, is widespread in the animal kingdom. Despite this, we know very little about the causes and consequences of partial migration, at least partly due to the logistical difficulties in collecting robust data in many species. I propose a project that takes advantage of an established and highly productive study system to answer fundamental questions about the evolution of partial migration in animals using an innovative combination of methods. Firstly, I will ask what drives some individuals to migrate and some to remain resident? Here I will empirically test predictions from a conceptual model that I recently developed which proposes that individual differences in predation risk and/or growth can explain patterns of partial migration. Specifically, I will investigate the role of an individual's position on a behavioural syndrome (i.e. personality) upon migratory behaviour, and predict that fish with bold personalities (that have high individual predation vulnerability) will be more likely to migrate than fish with shy personalities. I will also test the idea that individual differences in feeding niche (trophic polymorphism) influence an individual's migratory behaviour using stable isotope and geometric techniques. Secondly, I will investigate the population genetic consequences of partial migration, and assess its potential as a diversifying force in this system. The project will use a variety of cutting edge behavioural, ecological and molecular techniques to address these fundamental questions, using my established model system, the roach Rutilus rutilus. This novel project will provide a unique opportunity to answer questions on the evolution of partial migration, and indeed migration itself.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Price multipliers in the options market.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

A novel line of research suggests that financial assets react to demand similarly to other products; in contrast with the classical view of inelastic demand for financial products. This new paradigm implies that data on holdings is extremely useful for predicting price changes and creating counterfactual scenarios. Until now, empirical evidence focused on equities and, to a lesser extent, bonds supports the new paradigm. This project focuses on a different asset class, option derivatives. This financial product has grown exponentially in the last decade due to financial market improvements; therefore, demand has boomed, potentially elevating prices. The main question of this proposal is how much option prices rise due to an increase in demand. A high increase will make these instruments less attractive as hedging devices. Consequently, the investor base has shifted towards a more speculative base, including retailers whose participation has sky-rocketed in the last decade despite having realized enormous losses over the last few years. We need two main ingredients to assess the effect of demand on prices. First, we need investors' holdings. In contrast to equities and bonds, regulators in most countries do not require detailed derivative positions. This grant will use a novel dataset from Brazil, where the regulator forces funds to report all positions on any asset they hold (or short). Second, we need a method to disentangle which price movements are due to changes in demand. This grant will adapt the recently developed method of granular instrumental variables to options. I will develop this action at Nova SBE in Portugal under the supervision of Prof. M. Ferreira, where I will also receive training and career development to improve my skills. By joining Nova SBE, I w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Radionuclide Metrology for Safeguards, Environment and industry'.

assistant: **Objectives**

Specific Objectives:1. To standardise a 134Cs solution and a 137Cs solution;2. To standardise a 137Cs solution and a 137Cs solution;3. To perform the first underground measurement of Hiroshima samples;4. To design a new type of ULB HPGe detector for HADES;5.To assist in radiological emergencies;6. To certify 6 IAEA reference materials for their radioactive components;7. To prepare 235U Reference Samples for the EUROMET Project 591;8. To train a PhD student in ultra-low level radioactivity measurements;9.To supply mass and length metrology services to other JRC actions. Anticipated milestones and schedule This Action is of a horizontal kind - it concerns mainly services to customers. Hence, this schedule is not complete - only the major projects are listed - as far as they are known today. First underground measurement of Hiroshima samples: sample preparation, distribution of samples, measurements (Jan. - Dec.). A new type of ULB HPGe detector for HADES: design (Jan. - Dec.)Intercomparison with CTBTO (UN): planning (Jan. - Dec.). Ultra low-level measurement of swipe samples for ESO (DG TREN): this is a continuous service. It is expected that some 10 samples per year will be analysed (Jan. - Dec.). Assistance in emergencies: develop procedures (Jan. - Dec.). Preparation and reference measurements of samples for customers: this is a continuous service e.g. 134,137Cs standard solutions, 235U samples, IAEA RMs (Jan. - Dec.). Mass / length metrology: this is a continuous service (Jan. - Dec.). Benchmarking of radioactivity in European steel (similar to the benchmarking exercise of German steel performed in FP5): Discussions with DG ENV and CELLAR partners (Jan. - Dec.). Planned Deliverables:1. Primary Standard solution of 134Cs;2. Primary Standard solution of 137Cs;3. Sample
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Global System for Telematics enabling On-line Safety Services'.

assistant: **Concept**

During the last decade, advances in communication technology and on-board vehicle electronics have set the stage for a giant leap forward in the history of the automobile, namely the transition from autonomous units to communicating, highly-interactive systems that share intelligence with each other and their environment. Making the vehicle and its occupants an integral part of the information society will allow easing existing tensions between the vehicle and its environment and help to bring the automotive experience as well as overall mobility to unprecedented levels. GST is a major initiative mobilising more than 50 key stakeholders in the European telematics industry. It will provide the building blocks to carry out the transition from closed to open systems as this is the key to bring telematics functionality in all new vehicles and unlock the market for on-line services. GST seeks to establish this openness by further decoupling service development, service operation, delivery infrastructure, payment, in-vehicle software, in-vehicle hardware and in-vehicle networks.The project will tie together the existing results of European, national and corporate research programmes and progress the state-of-the art focusing on missing links for which enabling specifications and standardisation proposals will be developed. To do so, specific skill-sets have been mobilised in different sub-projects covering specific technological building blocks that are missing (these are the Open Systems", "Security", "Payment" and "Certification" sub-projects) as well as covering some specific on-line services that are essential for helping to bring the market to fruition (these are the "Rescue", "Enhanced Floating Car Data" and "Safety Channel" sub-projects)."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evidence-based probiotic for Chronic Fatigue Syndrome'.

assistant: **Innovation**

Let’s imagine being tired to the point where any activity causes weeks of weakness and pain. Common noises and daylight become an unbearable torture and a “brain fog” doesn’t let you think clearly. In spite of the tiredness, you wake up without being refreshed, if you can fall asleep at all. Days pass as well as doctors check-ups, and no one is able to tell you what is wrong. Finally, after few years of trying to pull yourself up, the answer is Chronic Fatigue Syndrome (CFS). Happy of the fact of being diagnosed, you quickly learn that it means that there are no measures able to cure you and chances of full recovery are only 5%. Indeed, the reality of CFS patients’ life is tough and contrary to many beliefs it is not a rare disease. The world count of diagnosed CFS is estimated for up to 24 million cases and considered to be only 10% of the whole CFS population. Although frequently triggered by infection, cause of CFS is not yet known. Researches look for its source in the guts, which are inhabited by billions of microorganisms and form a complex ecosystem with profound impact on the whole body. Imbalance of gut microflora, damaged gut barrier functions and dysfunctional immune responses are known in CFS and shared with another disease - Irritable Bowel Syndrome (IBS), which frequently accompany CFS.GutMagnific™ is an evidence-based probiotic scientifically designed and shown to be effective in correcting the gut microflora disbalance – a source of CFS and IBS symptoms. The novelty of the product lies in the unique combination of 5 lactobacilli strains with evidence-based efficacy and shows a life-changing promise to severely underserved population of CFS patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimized drug combinations for effective cancer treatment: a personalised approach.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project aims to improve the treatment of metastasized colorectal carcinoma (mCRC), as treatment options after first line chemotherapy are desperately needed. The key to improvement of cancer therapy resides in optimal combination of drugs. Optimally combining drugs is non-trivial due to the large number of possibilities, especially when more than two drugs are combined at various doses. In the current research program I propose to use a differential evolution guided stochastic search algorithm to guide the way in finding optimal combination therapies. In previous research I have applied this feedback system control (FSC) technique to navigate through the enormous parametric space of nine angiostatic drugs at four doses. The straightforward iterative approach of in vitro cell viability testing and algorithm-based analysis identified optimal synergistic low-dose drug combinations. In vivo translation by maintaining the drug dose ratio led to effective anti-cancer activity, without evidence of side-effects.     A new screen for optimal targeted combination treatment of advanced CRC will be performed. A series of 7 genetically different human CRC cell lines will be used in this screen, thus simulating personalized treatment. The optimized combinations will be ‘ratiometrically’ translated into orthotopic and metastasizing preclinical CRC mouse models and tested in parallel to standard chemotherapy regimens. Development of a method for a personalized screen using freshly isolated tumor cells will prepare the technology for application in the clinic.      Using an innovative strategy I previously identified a series of novel markers of the tumor endothelium. After validation of these targets, this project aims for the design of new drugs to be used in a screen for optimal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SEWAGE MONITORING SYSTEM FOR TRACKING SYNTHETIC DRUG LABORATORIES' under Horizon 2020.

assistant: **Concept**

The threat of synthetic drugs is one of the most significant current drug problems worldwide. Amphetamine-Type Stimulants (ATS) are the second most widely used drugs. Since 1990, ATS manufacturing has been reported from more than 70 countries worldwide and the figure keeps rising. In 2008, 80 % of the amphetamine production facilities dismantled worldwide were located in Europe (UNODC, 2010) (EMCCDA, 2011). Organised Crime Groups are involved in ATS large-scale production (Europol, 2007) (EMCDDA, 2009). Since 2011, the wide availability of pre-precursors (like APAAN) significantly lowered the price of the controlled precursor BMK and caused severe environmental problems, taking the problem to a greater dimension.The aim of this project is to design, develop and test a prototype of a system for legal recording, retrieving and monitoring operations of ATS and ATS precursor laboratories in urban areas. The sensor system will be installed within the sewage system and will track waste associated to ATS production. Criminal investigators and forensic specialists will use the system in case of:1. initial general suspicion of ATS production in a certain area, for locating laboratories by monitoring the sewage system for long time periods;2. strong suspicions that in a well confined area ATS is being produced, for collecting material for forensic analysis and potential use in court, and for aiding in the planning of LEA raid operations. The μMole prototype will contain the following features: a) miniaturized system for 200mm sewage pipes, b) robust housing taking into account sewage system environment, c) minimized power consumption, d) enhanced operation time supported by energy harvesting, e) high-specificity electro-chemical sensors, f) integrated micro-tanks for sample stora