RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting the miR-106b~25 cluster in pathological Cardiac Hypertrophy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

BACKGROUND: There is a tremendous need to develop novel therapies for heart failure. In particular, sustained pathological hypertrophy, a major predictor of this condition, is a complex process, which involves transcriptional and posttranscriptional regulation of the cardiac genome. There is now clear indication that, besides a few known transcriptional regulators, multiple, still poorly understood cardiac factors are involved in hypertrophy; understanding this complexity is expected to pave to the way to innovative therapies.  In particular, recent data demonstrate that dysregulated microRNAs (miRs) are associated with heart failure, and that selective modulation of miRs can provide therapeutic benefits. Our pilot-data show that expression of the miR-106b~25 cluster decreases during pathological hypertrophy in mice and that virus-mediated overexpression of this cluster prevents phenylephrine-induced hypertrophic remodeling. Following bioinformatics screens for potential direct downstream targets of the miR-25~106b cluster, we identified a series of transcription factors, which might play a role in pathological cardiac remodeling.AIM: To define the functional implication of the miR-106b~25 cluster in pathological cardiac hypertrophy and to exploit this information towards the development of novel therapeutic approaches.APPROACH: We will identify direct downstream targets of the miR-106b~25 cluster during hypertrophy, by performing Ago2-Immunoprecipitation and by treating neonatal cardiomyocytes with precursors of miR-25, miR-93 and miR-106b, followed by next generation sequencing (Objective 1); We aim to reverse pathological cardiac remodeling and prevent heart failure by delivery of recombinant adeno-associated virus (rAAV9)- miR-106b~25 in mice (Objective 2). The resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigation of high frequency applications for PVDF and optical hydrophones for measurements of the acoustic output of diagnostic medical ultrasonic devices' in the context of a Fourth Framework call.

assistant: **Objectives**

Background Ultrasonic devices used in medical diagnostics are increasingly employing ultrasound frequencies beyond 15 MHz. For dosimetry of these systems there is the need for appropriate means and methods of measurement. So far PVdF hydrophones are used for these measurements and fibre optical detection schemes are tested. Concerning measurements with PVdF hydrophones IEC standards only cover the frequency range up to 15 MHz (there exists a draft standard for the range up to 40 MHz). Fibre optical detectors are not yet dealt with in any IEC standard. Objectives The overall objectives of the project are  to develop a new miniature PVdF needle hydrophone with about 50#m diameter. Due to its size it is expected to be better suited for detecting high-frequency ultrasound than larger hydrophones.  to further develop and improve the techniques of a fibre optical pressure sensor as a standard measurement device for ultrasonic diagnostic and surgical systems. The fibre optical sensor to be employed (Laser Probe Hydrophone LPH) is based on the principle invented by Eisenmenger and Staudenraus.  to further improve the measurement methods and techniques for acquisition of important acoustic field parameters with respect to IEC standard 1157 employing (and mutually relating) the above described optical and piezo-electrical detectors. The particular objectives of the first stage of the project are  Production and characterisation of acoustically well defined ultrasonic sources  Design of the miniature PVdF hydrophone  Establishing the LPH system for defined and reproducible measurements Work programme The programme to meet the above objectives comprises the following stages:  Optimisation of the LPH for the detection of diagnostic ultrasonic pressures.  Exact calibration of the LPH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hard metal machining in a jobbing shop type environment' in the context of a Fifth Framework call.

assistant: **Objectives**

This research is intended to provide a solution to the problem of conventionally machining hard steels and nickel based alloys turning, milling, drilling and tapping at rates and costs superior to grinding. This has to be achieved in the manufacturing environment of the jobbing shop, where batch size is small, geometric shape is variable, set-up, turn-round time and delivery are expected to be short and flexibility at a maximum, yet operating and capital costs need to be low. The main objective is to describe a cost effective method based on the use of ultra hard tools. The method will extend research already carried out by large companies by carrying out selected machining tests on surface hardened steels and nickel alloy steels by observing wear mechanisms, chip/tool interface metallography & temperatures and cutting forces. This will be followed by process trials, product and cost evaluation. The participating Sees will rapidly introduce successful methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Deterministic and integrated processes for fabricating freeform optics by means of computer-controlled optical surfacing'.

assistant: **Objectives**

Computer-controlled optical surfacing (CCOS) is an advanced manufacturing technology and a deterministic method for the production of high-precision (HP) optics. Carl Zeiss (CZ) has developed two basic methods for the generation of high accuracy optical surfaces: small-tool computer-controlled polishing (CCP) and ion beam figuring (IBF).The invention and realisation of magnet or heological finishing (MRF) of QED Inc. in America for the production provided a major stimulus to the progress of the deterministic manufacture of HP optics, and the US took the lead in this area. Since the development and improvement of cost-effective production processes is of crucial significance to worldwide competitiveness, CZ has established a team (CCP team) to work on investigating innovative CCOS.The CCP team currently consists of experts specialising in various areas, with the exception of mathematical algorithms. It is therefore the intention of this proposal to recruit an expert with a good knowledge of mathematical algorithms and a background in software and manufacturing engineering within the scope of the ToK programme. He/she will be working with the CCP team.The main aim of the work is to optimise the CZ algorithms using synergy effects by analysing all available algorithms for the CCOS of freeform optics, in particular those for MRF, to integrate CCOS into the overall process and, finally, to extend into the virtual manufacturing of freeform optics using an innovative full-surface tool named the adaptive elastic polishing tool which has yet to be developed.The results of the fellow's work will help Zeiss to reduce the gap to the US in MRF and directly influence CZ's competence in the cost-efficient manufacture of freeform surfaces.Achievements in the field of this advanced manu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Actively Frozen - contextual modulation of freezing and its neuronal basis' in the context of a Horizon 2020 call.

assistant: **Objectives**

When faced with a threat, an animal must decide whether to freeze, reducing its chances of being noticed, or to flee to the safety of a refuge. Animals from fish to primates choose between these two alternatives when confronted by an attacking predator, a choice that largely depends on the context in which the threat occurs. Recent work has made strides identifying the pre-motor circuits, and their inputs, which control freezing behavior in rodents, but how contextual information is integrated to guide this choice is still far from understood. We recently found that fruit flies in response to visual looming stimuli, simulating a large object on collision course, make rapid freeze/flee choices that depend on the social and spatial environment, and the fly’s internal state. Further, identification of looming detector neurons was recently reported and we identified the descending command neurons, DNp09, responsible for freezing in the fly. Knowing the sensory input and descending output for looming-evoked freezing, two environmental factors that modulate its expression, and using a genetically tractable system affording the use of large sample sizes, places us in an unique position to understand how a information about a threat is integrated with cues from the environment to guide the choice of whether to freeze (our goal). To assess how social information impinges on the circuit for freezing, we will examine the sensory inputs and neuromodulators that mediate this process, mapping their connections to DNp09 neurons (Aim 1). We ask whether learning is required for the spatial modulation of freezing, which cues flies are using to discriminate different places and which brain circuits mediate this process (Aim 2). Finally, we will study how activity of DNp09 neurons drives f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Emergent Connectors for Eternal Software Intensive Networked Systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The CONNECT Integrated Project aims at enabling continuous composition of networked systems to respond to the evolution of functionalities provided to and required from the networked environment. At present the efficacy of integrating and composing networked systems depends on the level of interoperability of the systems' underlying technologies. However, interoperable middleware cannot cover the ever growing heterogeneity dimensions of the networked environment. CONNECT aims at dropping the interoperability barrier by adopting a revolutionary approach to the seamless networking of digital systems, that is, synthesizing on the fly the connectors via which networked systems communicate.  The resulting emergent connectors are effectively synthesized according to the behavioral semantics of application- down to middleware-layer protocols run by the interacting parties. The synthesis process is based on a formal foundation for connectors, which allows learning, reasoning about and adapting  the interaction behavior of networked systems at run-time. Synthesized connectors are concrete emergent system entities that are dependable, unobtrusive, and evolvable, while not compromising the quality of software applications.  To reach these objectives the CONNECT  project undertakes interdisciplinary research in the areas of behavior learning, formal methods, semantic services, software engineering, dependability, and middleware.  Specifically, CONNECT will investigate the following issues and related challenges: (i) Modeling and reasoning about peer system functionalities,  (ii) Modeling and reasoning about connector behaviors, (iii) Runtime synthesis of connectors, (iv) Learning connector behaviors,(v) Dependability assurance, and (vi) System architecture. The effectiveness of  CO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Micro-realities of surrogacy in India' (SURROG-INDIA).

assistant: **Innovation**

Surrogacy is a (new) way to conceive children, which is currently becoming a medical, political, and social issue in a context of growing globalization and reproductive medicalization. India has become an international leader for surrogacy and one of the main destinations for cross-border fertility care for Europeans.Surrogacy sheds light on new social, economic, demographic and medical issues at the national and international levels. It raises many questions in epidemiology and public health (why do Europeans use surrogacy instead of adoption for example? why and how do they use surrogacy in India?), demography (who are the intended parents and where do they come from? who are the Indian surrogate mothers?), sociology (what are the life-histories of intended parents and surrogate mothers? what leads them to surrogacy? what sense do they give to this practice?) and gender studies (what is its impact on women’s conditions, on gender construction and on gender relationships? In a context of poverty, what justifies for Indian women to “rent their wombs”?).Through a mixed approach of qualitative and quantitative analysis, the project will study micro-realities of surrogacy in Mumbai among surrogate protagonists and will produce new empirical data. Based on training-through-research, the Marie Curie grant will assert my skills in three identified areas: generating knowledge on a new cultural background, strengthening my competencies in the field of survey methodology and enhancing my coverage of reproductive health issues by tackling the specific question of surrogacy.While surrogacy is becoming in Europe a burning issue for public health policies, few studies have addressed this new phenomenon, especially in developing countries. Understanding this practice both in terms of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Natural Antimicrobials For Innovative and Safe Packaging' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of the present project is to develop novel packaging technologies that will avoid/reduce and detect the growth of pathogens and spoilage microoganism responsible for product lost in perishable food products of interest: fresh fish, fresh chicken and minimally processed vegetables (MPVs). The target foods were selected among many, for different reasons: the consumption of MPVs is hugely increasing in all European countries and therefore, it is important to heighten the vigilance around that products; it is necessary to rebuild a consumers’ confidence for chicken; fish is probably the most perishable product. Anyway, any of them is an increasing area of consumption and interest. The new technologies will improve food quality and extend the relatively short life of these fresh food products. The concern about synthetic preservatives is steadily rising, due to a limited documentation on safety and tolerance. Instead, Natural Antimicrobials (NAs), which occur abundantly in environment where they evolved as host defence mechanisms, are generally considered as safer and better tolerable. Though NAs will be used in the active material development, a systematic and scientific based work will be carried out in order to fully assess the safety of the new packages developed. Thus, along three years, NAFISPACK will develop novel food packaging technologies and novel tools for risk-benefit assessment of these technologies (basis for a risk management tool and address policy needs in the area of food contact materials): i) Active packaging technologies based on natural antimicrobials ii) Intelligent packaging technologies based on monitoring of quality indicating metabolites iii) Combination of both antimicrobial and intelligent packaging technologies aimed to incre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum Dynamic Control of Atomic, Molecular and Optical Processes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Project represents a coordinated experimental/theoretical effort in developing and testing quantum protocols. Within a worldwide academy and industry effort to develop quantum computers, based on quantum qubits and quantum Hamiltonian, the quantum protocols, i.e. well designed Hamiltonian acting on the qubits, represent important steps. Even if the qubits offer enormous computation power, the quantum target may be reached more efficiently, more rapidly and with more stability using properly designed quantum protocols. Within this Project These new protocols will be tested on the natural qubits easily assessed in worldwide research laboratories: simple atoms and molecules. The experimental and theoretical tools should be classified with the broad area of quantum optics, where the photons, typically from laser sources, create the control quantum protocols, and the atoms/molecules constitute the qubits where quantum information is stored and maipulated. The Project will apply this quantum control approach to open theoretical and experimental problems such as: implementation of a molecular all-optical spin switch via control of spin-orbit interaction, realization of molecular orientation, superadiabatic protocolsfor the coherent control of cold atoms  and molecule, control of ultracold chemical reactions, and spin-polarized quantum emitters. The objectives of the project will be achieved via an intensive transfer of knowledge among the EU and TC participants in the consortium during the carefully planned secondments. The consortium members are well established specialists in various aspects of physics of light-matter interactions, including theoretical, experimental and numerical techniques, and therefore all participants will benefit from the SE scheme for staff exchan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Solutions and Technologies for deep Energy renovation Processes UPtake' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The 2018 EPBD update identifies deep renovation as key to drastically reduce energy demand and achieve the EU vision of a decarbonised building stock by 2050. The technology to achieve this reduction is available on the market today. Renovation rates are still far from the target 3% and shallow retrofits persist with low impacts on energy consumption. StepUP  will develop a new process for deep renovation for decarbonisation, with fast design to operation feedback loops to minimise performance gap and optimise investments. The project will deliver plug&play technologies for minimal disruption, interconnected for maximum impact on energy, costs, IEQ and user comfort. The new iterative approach to renovation, based in big data for continuous performance improvement, will reduce financial barriers and make decarbonisation of existing buildings a reliable, attractive investment. StepUP will:1. Make renovation more attractive and reliable with a new methodology based on near-real time data intelligence to identify cost-optimal, high impact interventions at any stage of the building life;2. Reduce the performance gap to 10% via an integrated life-cycle software platform to plan renovation steps, identify high value ECM, improve IEQ, integrate RES (including storage) and optimise operations by constantly refining and verifying targets and constraints;3. Minimise time on site to 40% by advancing innovative technologies for deep renovation to a market-ready renovation package of Plug & Play Technologies, including RE generation and storage for decarbonisation;4. Optimise renovation investments via innovative financing models for optimisation of energy, comfort and cost performance over the building life, based on progressive financing and building performance as a service;5. Acc