RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Therapies for inborn errors of metabolism' (IEMTX) targeting Seventh Framework.

assistant: **Abstract**

We discovered that phenylbutyrate, prevents both in vitro and in vivo the inactivation by phosphorylation of the branched chain ketoacid dehydrogenase complex (BCKDC) and pyruvate dehydrogenase complex (PDHC). We show that phenylbutyrate is effective for treatment of maple syrup urine disease (MSUD) due to deficiency of branched chain ketoacid dehydrogenase complex (BCKDC), and has potential for therapy of deficiency of pyruvate dehydrogenase complex (PDHC). We propose to investigate phenylbutyrate for PDHC deficiency in a zebrafish model and in PDHC-deficient patients. We have recently developed a systems biology tool for prediction of drug mode of action starting from their gene expression profiles. This tool has a significant potential for drug discovery and repositioning. Through this approach, we found several FDA-approved drugs sharing with phenylbutyrate a similar mode of action. We propose to investigate the efficacy of these drugs for increasing the enzymatic activity of both BCKDC and PDHC and their therapeutic potential. While useful for proof-of-concept studies animal models are not suited to predict patient response to drugs which depends upon multiple factors including type of mutation and affected enzyme subunit. We propose to develop PDHC deficient neurons and MSUD hepatocytes from induced pluripotent stem cells (iPSCs) derived from patients’ fibroblasts. Drug response in these disease-relevant cell types will better predict clinical response of patients. Human iPSCs will be generated through a novel system based on high cloning capacity, non-integrating helper-dependent adenoviral (HDAd) vector expressing a combination of reprogramming factors. We will investigate altered metabolic pathways in PDHC deficient neurons and MSUD hepatocytes to search for ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FAMILIES AND MEMORIES OF ITALIAN PRISONERS OF WAR IN YUGOSLAVIA AFTER WORLD WAR II' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

IT-POW FAMILIES is proposing a research on the experience and memory of the families of Italian POWs held in Yugoslavia after WWII. The main goal is to study, understand and communicate the history of POWs through 3 family stories (case studies), using the paradigm of microhistory, the methodology of oral history and the tools of public history, and to effectively promote the outcomes among the non-academic society. The personal experience of POW families and the persistence and transmission of trauma through generations have not been studied up to now, thus the project will go beyond the state-of-the-art by giving voice to people that are not directly involved in war operations, but suffer the consequences (especially mothers, wives and children). The aim is to raise European awareness of how WWII had a big influence on the lives of people also years after the end of the war and, in this way, increase the understanding of the situation Europe is facing today (the refugee crisis). The project fits in one of the most relevant European challenges of Horizon 2020: ""Europe in a changing world – Inclusive, innovative and reflective societies"". My studies have so far been focused on diplomatic, political and military history of the Italo-Yugoslav relations, but not on social history and oral sources. The proposed project, thus, aims to fill not only the state-of-the-art gap of such studies, which are in general very rare in relation to the experience of POWs families, but as well widen my knowledge, ability and skills in the field of social, oral and public history. This will definitely become a big asset and virtue to my portfolio and make me a more competent and complete not only historian, but European citizen as well. In addition, the project intends to make a step forw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Realization and Manipulation of a Planar hybrid superconducting Andreev spin qubit in GErmanium' (RAMPAGE) targeting Horizon Europe.

assistant: **Abstract**

In the boiling field of quantum technology, the development of a stable, inherently shielded from perturbations quantum register is essential, yet remains elusive. Hybrid semiconductor-superconductor devices have been intensively studied, hunting for Majorana bound states towards topological quantum computing. While this goal has not yet been achieved, it has spurred material developments in III-V semiconductors, creating a new playground for spin qubits, resulting from the hybridization of the semiconductor and the superconductor in 1D Josephson junctions. Pioneering experiments recently demonstrated the manipulation of such a hybrid qubit, the Andreev spin qubit (ASQ), highlighting the potential of this approach. However, it is now reaching its limits due to the intrinsic properties of the host III-V semiconductor and the nanowire geometry, calling for a more suitable platform not demonstrated to date. In this proposal, I will tackle this challenge by fabricating a hybrid electrostatically tunable 1D Josephson junctions from a 2D germanium heterostructure. The first realization of a 1D Josephson weak ling on a planar Ge heterostructure will experimentally prove the possible integration of hybrid junctions, with resolved Andreev bound states. This device will enable the study of the spin-orbit interaction Hamiltonian for holes in 1D, a topic that remains largely unexplored leveraging microwave spectroscopy of Andreev bound states. Then, harnessing the unique properties of Ge, I will realize the first ASQ on a group IV semiconductor heterostructure. The proposed hybrid superconducting ASQ sets a significant milestone in the field, paving the way towards larger ensembles and enabling straightforward microwave connectivity using standard circuit quantum electrodynamic tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Strategies for European ICT RTD Collaboration with Australia and Singapore'.

assistant: **Innovation**

SECAS targets the improved collaboration of European ICT researchers with their colleagues in Australia and Singapore based on an identification and demonstration of mutual interest in S&T co-operation, sharing best-practices and better research policies. It will identify topics and constituencies for deeper strategic collaboration, enter into a dialog with leading innovation communities, and identify common needs and opportunities for co-operative RTD. SECAS will use the RTD policy analytical capability of the consortium partners and from partners' countries, information events, and interviews with experts from industry and academia. SECAS is an initiative of leading policy advisors, a national ICT institute, and ICT innovation researcher. Previous analyses and existing networks will be exploited to leverage SECAS impact to all ICT areas relevant to industrial and academic RTD co-operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Integration of environmental signals in hormonal regulation of decapod crustaceans'.

assistant: **Innovation**

This project aims to improve understanding for the causal relationship between long-term changes of environmental factors elicited by climate change, i.e. temperature and ocean acidification, and organismal performance of an ecologically and economically highly important group of aquatic arthropods. Physiological, biochemical and molecular methods will be used to study how these environmental factors acutely and chronically affect molecular signalling mechanisms of hormonal regulation, growth, acid-base and ion regulation in various life stages of decapod crustacean species from temperate and subpolar latitudes. The life stages and species are expected to show differences in thermal tolerance and in their capacity for hormonal, acid-base and ion regulation, which would reflect differences in the sensitivities to climate change scenarios. This project explicitly addresses drivers of the EU Strategy for Marine and Maritime Research, the Life+ Programme and a major theme of the Cooperation Programme. It will be particularly useful in assessing and predicting vulnerabilities to the increasing environmental pressures on ocean ecosystems and biodiversity due to climate change. Training in molecular cell biology and endocrinology at Colorado State University, Fort Collins, USA and Bodega Marine Laboratory, UC Davis, USA will significantly foster the applicant’s career development and reintegration into the European Research Area at the Alfred Wegener Institute for Polar and Marine Research, Bremerhaven, Germany.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European-central asian solar energy conference tashkent may 2003', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Introducing renewable energy predominantly in remote areas and guaranteeing reliable energy on urban area by integrating RES are of great importance for the Central Asian society. Experiences from installed systems in Europe will support to become familiar with such an innovative technology. Experts in the field of wind energy, Photovoltaic, solar thermal energy and heat pumps will present actual trends, experiences from the very beginning of this technology with first systems as well as the necessary efforts to create a stronger market and dissemination needs. General economic aspects will be treated, the vision of a full renewable energy society, social aspects and the general basic needs for each renewable energy system which is energy saving and efficient use. For being flexible during the Conference smaller working groups will get the opportunity to intensify discussions and to create joint project ideas. The possibilities of financing common projects should be addressed finally. A book of abstracts of the conference should give a complete overview of the content. An internet homepage will finally contain all lectures and the main outcome of the workshops and the discussions as well as further steps in the European Central Asian co-operation in Solar energy. After the two days conference a third day for visiting the first remote solar systems and visiting famous Samarian is moreover dedicated to clearly define further steps of co-operations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The development of an advanced and safe sandwich-Panel overhead door system for applications in the industrial and public sectors' (1994-1998).

assistant: **Innovation**

A simple, safe, reliable and sustainable sandwich-panel overhead door system, which is inexpensive and maintenance-free, is highly desirable for both the industrial and the public segment (garage doors). Existing sandwich-panel overhead door systems which are based on old fashioned hinges constructions, have the following disadvantages: expensive, high maintenance costs, short life time and unsafe in use. The objectives of this project are: 1) the development of a hinges-free light-weight consruction of sandwich-panel overhead doors (excellent constructional linkage, reduced friction, etc.), 2) cost-efficient (35% price reduction), 3) improved thermal and audio isolation, and 4) maintenance-free modular system (easy assembly/replacement). The Overhead door system to be developed will be conform (future) safety standards and constructed from 100% environmentally-acceptable materials (Car C-See PUR-foam). The European market of sandwich-panel overhead doors is about 1.8 rni on m2, of which au market share of 10 - 20 % seems feasible. This corresponds with a turnover of 45 MECU to 9.0 MECU/year. The objective of the project is to optimize the technology of the hinges construction and the production method hereof as the basis for a completely new garage door concept.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Technology development for a reliable supply of high quality seed in blue mussel farming' (2002-2006).

assistant: **Concept**

The objectives are to secure a reliable supply of blue mussel seed and to develop techniques allowing farmers to market blue mussels year round. A problem blue mussel producers face is the unpredictability seed supply. Seed is mostly harvested from suspended substrates or mussel beds. The amounts of wild seed available are extremely variable from year to year. A reliable supply of seed from hatchery sources will allow mussel farmers to overcome this. A second problem is that recently spawned mussels cannot be sold due to insufficient meat content. Producers will benefit greatly from a hatchery-based technique, such as triploid induction, that produces non-maturing mussels that can be marketed year round. Mussel farmers and sellers, a network for training and technology transfer, universities and research institutes will collaborate in five workpackages. Internal project management will be taken care of in Workpackage 1. Workpackage 2 will give attention to broodstock conditioning and larval rearing. Workpackage 3 will deal with production of triploid larvae and tetraploid broodstock. Workpackage 4 will concentrate on spat settlement and on rearing of diploid and triploid spat to seed size. Workpackage 5 will compare the allowed costs of hatchery produced seed with conventional wild-caught seed. In addition, knowledge transfer between RTDs and SMEs and the dissemination and exploitation of results outside the consortium will be ensured. Considering the normal 2 to 3 year production cycle for blue mussel in Europe, the focus of the project will be on spat and seed production. The project outcomes will include a reliable method to produce triploid seed, allowing year-round production of high quality mussels, protocols for spat and seed production, and an analysis of the ec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Philosophy of the Web: From Hypertext Representations to Collective Intelligence' under Seventh Framework.

assistant: **Concept**

In the wake of its technological success and the structural change the World Wide Web has effected on the world,  Web designers and researchers are being forced to confront a range of foundational issues with clear philosophical dimensions. These include old philosophical issues in modern guises – issues concerning knowledge, identity and language – as well as new questions raised by the increasingly complex ways in which the Web is embedded in the larger world, as embodied in the Semantic Web and Internet of Things initiatives.  In an world increasingly dominated by information technologies like the World Wide Web, our very nature as individuals is gradually changing as our cognitive and social capacities seem increasingly externalized.  However, philosophers has only just begun to connect the information technology like the Web to both a French tradition of systematic philosophy that explores the historical origins of conceptual structures and the rigorously analytic Anglo-American approach that requires all claims to be grounded in logic and empirical evidence. By virtue of this fellowship, we hope to begin a wider project that in an innovative manner that binds both these philosophical traditions to a  common empirical object of study: the World Wide Web. What is required is a strictly interdisciplinary approach that seeks to place the emerging work in information science on the Web within a larger framework that includes cognition and embodiment, and likewise have that framework be shaped by the latest scientific and technological development of the Web. This fellowship aims to facilitate and structure this goal by by having the work of renown French philosopher of technology Bernard Stiegler serve as the foundation for an analysis of the Web.   The eventual goal o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Next generation Pass-By Noise approaches for new powertrain vehicles' (PBNv2).

assistant: **Innovation**

With transportation noise being the second most deadly environmental pollutant in Europe, engineering for future mobility must be inspired by ecology, economy and health to enable green and silent vehicles. Legislations define maximum noise emission limits that have to be complied with during standardized pass-by noise test procedures. Given novel, often electrified, vehicle powertrain concepts, new pass-by noise evaluation approaches are required.The proposed PBNv2 project (Next generation Pass-By Noise approaches for new powertrain vehicles) brings together early stage researchers and experienced specialists from key players in academia and industry across Europe covering different scientific disciplines and industrial stakeholders form a broad range of backgrounds to optimally tackle the challenges ahead. The Fellows will be trained in innovative PhD topics as well as receiving specific theoretical and practical education in the field of pass-by noise engineering, tackling as well the pass-by noise aspects of the ‘source’, the ‘transfer path’ and the ‘receiver’.PBNv2 is formed by 10 beneficiaries combining leading education institutes, top research institutions and leading companies as well as 7 partner organisations established in European automotive R&D, to assist in the dissemination and public engagement or PBNv2 results, and in providing dedicated training to enhance the entrepreneurial mind set of the ESRs. The Fellows will profit from top scientific research guidance in combination with highly relevant industrial supervision. Together these participants address the triple-I dimension of research training, being International, Interdisciplinary and Intersectoral. Furthermore, the industry will gain from the specific training of the young researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Climate change, energetic constraints and susceptibility to environmental stressors in Antarctic seabirds: integrating stress physiology and population heterogeneity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In Antarctica, climate change has negative impacts on seabird populations. However, this change is likely to differentially affect birds depending on their age, experience and quality. This heterogeneous response to climate change deserves attention because it will affect the structure of populations and thus, their health status. This project aims to examine how age, experience and quality can functionally affect the way Antarctic seabirds respond to environmental perturbations. Moreover, we will focus on physiological age because it is more likely to determine bird’s response to perturbations than chronological age. To sum up, we aim to examine how age, experience and quality determine to what extent parents (1) are energetically constrained; (2) regulate their parental investment when facing perturbations. We will use (a) stress physiology (corticosterone, COR) to test our hypotheses; (b) telomere dynamic to measure physiological age. In the context of global change, COR physiology is promising because it mediates the response of an organism to environmental stressors: COR physiology is a system with 2 functional levels (baseline and stress-related COR levels), which have been suggested as indicators of energetic constraints and parental investment. However, data are lacking to confirm this interpretation. We will link the knowledge in stress and aging physiology of Wingfield with the long-term ecological data set of the CEBC-CNRS and we will use innovative techniques to address three questions: (1) Is telomere length a reliable measure of physiological age? (2) Can baseline COR level and COR stress response mirror energetic constraints and parental investment? (3) Do age (chronological, physiological), experience and quality interact with environmental conditions to