RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Metamorphosis as a driver of biodiversity? From a single genome to multiple phenomes'.

assistant: **Objectives**

Metamorphosis is one of the most fascinating phenomena in the animal kingdom, implying an abrupt change in morphology and ecology during the lifetime of an individual transforming it from a larva into an adult. Metamorphosis can be thought of as a second birth for an animal, emerging as a completely different organism, despite being produced from the same genetic material. From butterflies to frogs, almost all the successful and speciose lineages of animals are metamorphic, suggesting that metamorphosis may be an important driver of biodiversity. At the time of the sixth mass extinction, where one-fifth of living species are threatened, understanding whether development can be a driver of morphological and functional diversity, and whether it may be advantageous in allowing populations to adapt rapidly to changing environments is of prime importance. The goal of META-MORPHOSIS is to test the impact of metamorphosis on morphological diversification by disentangling the factors (developmental, functional, and ecological) shaping morphological diversity. I aim to 1) identify the patterns of morphological and functional variation depending on developmental strategies across species throughout ontogeny; 2) shed light on the origin and evolution of metamorphosis using the fossil record; 3) understand how metamorphosis fosters diversity and to quantify its impact on the generation of biodiversity. To do so, I will study salamander species with different developmental strategies and ecologies throughout ontogeny using a combination of state-of-the-art approaches, including phenomics (geometric morphometrics), analyses of function (feeding kinematics and forces), phylogenetic comparative methods, development, paleontology and methods exploring diversification. META-MORPHOSIS wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biodiversity change across time and space in the Anthropocene: Leveraging metacommunity modelling, land-use change, and open data to achieve deeper understanding' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Despite connections between metacommunity level processes that maintain biodiversity and anthropogenic pressures that erode those processes, these have not been well integrated. I propose a multifaceted approach that(1) builds on metacommunity theory to develop expectations for the influence of anthropogenic drivers on scale-explicit biodiversity change;(2) uses this theory to develop an analytical pipeline to disentangle local and landscape factors driving this change;(3) use the derived results to develop scale-explicit projections of future biodiversity change that can aide biodiversity policy decisions.With theoretical expectations and analytical procedures in hand, we will synthesize biodiversity change across scales, and the relative influence of local versus landscape-level drivers on those changes. We will apply our analytical pipeline to the largest compilation of metacommunity time series to provide a comprehensive analysis of biodiversity change. We will complement this with a data collection campaign to resurvey zooplankton metacommunities from ponds that had been surveyed 10-50 years previously, but which have experienced different levels of background change (e.g., loss of nearby habitat). We will also compile a database to explore the potential influence of habitat restoration via local and landscape processes, and its influence on scale-explicit biodiversity change. We will analyse these synthetic datasets together with geospatial driver data using our novel analytical pipeline. Finally, we will develop a unique pipeline integrating metacomunity theory with our synthetic results and machine learning to develop projections of biodiversity change in the face of scenarios of anthropogenic change. With the information gained, we will contribute not only to a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'IST-Africa (2016 - 2018)'.

assistant: **Innovation**

IST-Africa (2016 - 2018) has 4 complimentary objectives focused on strengthening ICT-related research and innovation cooperation between Europe and Africa: 1) Foster greater coordination of research and innovation activities; 2) Strengthen research and innovation linkages, increase awareness of research and innovation capacity and cooperation opportunities, and support mutually beneficial collaboration; 3) Monitor research and innovation activities in 17 IST-Africa Partner Countries to identify and provide input on common R&D priorities and future cooperation opportunities; and 4) Promote participation in ICT-39-2017 and other relevant Horizon 2020 calls, disseminate results from ICT-39-2015 and other relevant calls. IST-Africa (2016 - 2018) leverages results and achievements from previous phases of IST-Africa to realise its objectives. Coordination will be undertaken through national Horizon 2020 Train-the-Trainer Workshops and stakeholder meetings. Help Desk activities, international conferences and engagement with African and European stakeholders will assist in strengthening research and innovation linkages. Surveys will be undertaken across the 17 participating African Member States to monitor ICT-related research and innovation activities, map research and innovation capacity, priorities and bilateral cooperation initiatives to support future planning. Relevant calls will be promoted and results disseminated through national and international dissemination channels, physical meetings and conference presentations. All activities are well aligned with the work programme priorities through the organisation of research and innovation events and conferences with policy dimensions, monitoring of research and innovation activities, identification of common R&D priorities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Application of a New Kinetic Microbial Theory-Microbial Transition State- on Enriched Nitrifying Activated Sludge Model' (MTSonNAS).

assistant: **Concept**

Traditional engineering models known as Activated Sludge Model (ASM) are commonly used for operation, design, and optimization of wastewater treatment plants. ASM predict microbial growth with simulation and calibration of model parameters which are bound to a range of experimental conditions. Recently, Microbial Transition State (MTS) approach was proposed which is a statistical-physics based theory of microbial growth linking thermodynamic balances and growth rates. A growth equation was derived from these first principles, which links a flux (the growth of microbes) to a force, i.e. the Gibbs free potential energy density in medium contained in randomly distributed substrate molecules. MTS has not been fully verified with experimental data on mixed microbial cultures such as sustained in wastewater treatment systems. As the theory is developed for describing standard microbial growth, conditions such as inhibition of growth by any pollutant compound has not been considered/applied in real systems. The aim of the research is to investigate growth kinetics of two different nitrifying bacteria individually (Ammonia and Nitrite oxidizers) with MTS modeling approach and identify nitirification growth kinetics. Inhibition of bacterial growth with different types of inhibitors will also be investigated in order to evaluate and verify application of MTS model for different guilds in mixed microbial cultures under different environmental conditions. The outcomes of the study will contribute to understanding and control of microbial growth processes in engineered and natural treatment systems. Identification of inhibition kinetics will be used for mitigation of pollution generated from industrial processes as well as theoretical development of MTS theory to be applied in more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The first broad-spectrum treatment against pandemic-prone flaviviral infections: Dengue, West-Nile and Zika' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

WHO, governments and health institutes are urgently seeking methods to prevent future catastrophic flavivirus outbreaks affecting millions (annually >40% of the global population at risk, resulting in ~395M infections, >25,000 deaths of which mainly children, 750.000 disability-adjusted life years and >9B direct & indirect costs). As there are no effective treatments or vaccines available, ATLAS will provide a breakthrough in broad-spectrum antivirals: the first-in-class drug to combat the global health emergency of flaviviral infections. In the ATLAS project, Protinhi will finalize clinical trial-enabling studies and pharmaceutical development and obtain proof-of-concept in humans by conducting Phase I and Phase IIa clinical trials against the most common flavivirus: dengue. This will put the company in an excellent position to attract interest from pharmaceutical companies (e.g. Gilead, J&J, MSD) for a strategic partnership for late clinical development and commercialization.


**Keywords:** Pandemic Preparedness,West-Nile,Dengue,Prophylaxis,Therapeutics,Drug Development,Peptidomimetic,Outbreak Management,Flavivirus,Antivirals,Zika
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Roles of Class I PI 3-kinase isoforms in signalling and cancer' (2007-2013).

assistant: **Concept**

PI 3-kinases (PI3Ks) generate intracellular lipid second messengers that regulate many cellular processes including cell survival, proliferation, migration and differentiation. The PI3K signalling pathway has been implicated in diseases such as cancer, inflammation and diabetes, and PI3Ks are therefore considered as attractive new therapeutic targets in the pharmaceutical and biotech industry. Mammals have 8 isoforms of PI3K, and therapeutic interference with PI3K signalling may have to be targeted at individual (or groups of) PI3K isoforms, in order to overcome systemic toxicity. This research proposal aims to gain insight in the role of PI3K isoforms in cell transformation by selected oncogenes, and the associated signalling mechanisms. We also aim to uncover mechanisms by which cells can resist inactivation of one or more isoforms of PI3K, in order to gain insight into PI3K isoform-selective signalling pathways, but also as a prelude to understand possible therapeutic resistance to PI3K inhibitors. This study will make use of a series of unique PI3K gene-targeted mice, made in the Host Laboratory, and which are seen as the ‘gold standard’ in the field. For the signalling studies, we will make used of a new phosphoproteomic technique, called Targeted In-depth QUAntification of Signalling (TIQUAS; unpublished; patents pending), recently developed by the Host Laboratory. The overall aim is to identify isoform-specific protein kinase/phospho-peptide signatures that could also be used as biomarkers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New techniques in the simulation of quantum many-body systems in two dimensions: methods and applications' (PEPS-PROPOSAL).

assistant: **Concept**

A number of recent results in the field of quantum information science have lead to new and fresh ideas to attack old, long-standing problems in condensed matter physics. The study of quantum correlations (or entanglement) has motivated the development of a host of new promising methods to numerically simulate the physics of quantum many-body systems. Based on this, the aim of this project is to build new techniques to understand the physics of strongly correlated quantum systems in two dimensions. The expected outcome is a numerical package that will be amongst the best tools to understand the quantum-mechanical properties of these systems, in turn contributing to the study of the universal theory of quantum phase transitions and our understanding of quantum states of matter in Nature. These methods are also expected to a have significant impact in fields such as condensed matter physics, quantum-atom optics, lattice high-energy physics, quantum information and computation, and nanotechnology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Global and regional Earth-system monitoring using satellite and in-situ data' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Fifteen thousand excess deaths in the heat wave of summer 2003 showed that Europe lacks operational capabilities to provide adequate medium-range (3-7 day) & short-range (1-3 day) forecasts for natural disasters involving atmospheric chemistry & dy namics. This proposal, GEMS, will create new European operational capabilities for medium-range & short-range air-chemistry forecasts, through much improved exploitation of satellite data. The GEMS consortium comprises ten regional centres, most with o perational responsibilities for regional air-quality forecasting, ten leading research labs with capabilities & models on all aspects of atmospheric chemistry, two leading European labs, ECMWF with global operational weather capabilities, & the E U's JRC with global diagnostic capabilities. The research teams & ECMWF will develop a global operational medium-range forecast / assimilation capability for dynamics & composition, exploiting all available satellite data. The global forecasts wil l provide key information on long-range transport of air pollutants to the regional forecast models, through the forecast boundary conditions used by the regional systems. The improved regional forecasts will be used by air-quality authorities at city leve l, in dozens of cities across Europe. Based on the best science, the integrated forecast / assimilation capability will provide a powerful monitoring capability for greenhouse gases, reactive gases and aerosols. Sophisticated new inversion methods will be developed to infer surface fluxes of CO2 and other species through use of the surface flask data with the gridded atmospheric fields on transport & composition. The GEMS project will produce global retrospective analyses of the atmospheric dynamics and composition for the troposphere & str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis' (CarBon) under Horizon 2020.

assistant: **Objectives**

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic partners, 3 companies and 3 charitable foundations, working together to train 14 young scientists. We will combine knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology using skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery.In a multifactorial approach the network of young scientists will identify the biological and physical factors that determine the fate of cartilage. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. State of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated. The main objectives of CarBon are:- To establish a network of 14 highly skilled early stage researchers (ESRs) equipped with essential knowledge, scientific expertise, transferable skills and societal awareness as a foundation for their future careers. ESRs will be trained in cutting edge technology, communication, intellectual property and valorisation. - To understand cartilage to bone transition, to identify targets to develop novel functionalised biomaterials and to discover therapeutic drugs that either prevent or stimulate cartilage to bone tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'On the evolutionary significance of wild animal reproductive microbiomes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Our view of microbes has recently undergone a paradigm shift (the so-called microbiome revolution). Previously seen as unwanted harbingers of disease, it is now widely recognised that microbes can be beneficial and that the millions of microbes living in and on the bodies of animals and plants (i.e., the microbiome) can have profound effects on host biology. However, with the exception of the human vaginal microbiome, the microbiome revolution has largely overlooked the reproductive microbiome. This is especially true for wild animals. Yet, if we are to understand the evolutionary significance of host-associated microbiomes it is critical to study them in natural populations, where hosts exhibit greater genetic variability and are exposed to greater levels of environmental and microbial complexity. The aim of this proposal is to determine whether reproductive microbiomes impact host fitness and evolution in wild animals, and reveal the role of host genetics and immune functioning in shaping reproductive microbiome variability. I will leverage a unique wild system  the house sparrow  that can be studied in natural populations and in the lab, and for which I have recently pioneered the use of microbiome transplant techniques that allows me to disassemble and reconstitute natural microbiomes of nestlings. First, I will determine the fitness consequences and heritability of reproductive microbiomes in a wild population. Second, I will validate the impact of reproductive microbiome variability for reproductive success using novel in vivo microbiome transplants. Third, I will uncover the genetic basis of reproductive microbiome variation. Fourth, I will establish whether host immune functioning shapes reproductive microbiome composition. Altogether, I will significantly advan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Catalysts for Activation of Light Paraffins by Selective Oxidation' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Foreseen ResultsIf successful, the project will result not only in a better understanding of the studied reactions and improved catalysts for them, but also in the creation of new links of cooperation and a broader integration of research centres in a full European scale.The present project is aimed at developing basic and precompetitive knowledge for the design of new catalysts for the selective oxidative activation of propane and isobutane.The increasing demand of these light paraffins and the need of fairly pure feedstocks for their petrochemical use might cause the present capacity to become insufficient to cope with it.On the other hand, these paraffins are relatively abundant in refiner streams, being inexpensive and at present mostly used as energy carriers for combustion.Therefore, the objective of this joint research project would be the study and development of new catalysts for the selective oxidation of propane to acrolein and the oxidative dehydrogenation (OXD) of isobutane.The following stages are proposed to reach this goal:a basic study of catalysts, suitable for the target reactions (OXD of isobutane and propane to acrolein)based on this knowledge, the further development of catalysts through the optimization ofcatalyst preparation methods;catalyst formulations;the process operating variables for each target reaction.The first stage will include the synthesis of bulk or supported mixed oxide phases, as well as metal oxide-zeolite mixed systems, and the screening of their catalytic properties for the target reactions. The OXD of propane will also be studied on the same catalysts as a tool to obtain mechanistic information by comparison with these reactions. Simultaneously, the physico-chemical properties of the most promising systems will be studied by v