RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Digital Edition of the Roman de Florimont' under Horizon 2020.

assistant: **Concept**

The project aims to produce a digital scholarly edition of an overlooked text of the vernacular European Middle Ages: the Roman de Florimont, composed by Aymon de Varennes (Lyon, 1188). The edition will be complemented by a methodological reflection on the feasibility of new digital tools versus the availability and applicability of existing ones with respect to medieval vernacular texts characterised by extreme linguistic variation. Indeed, Florimont has many unique characteristics, starting from its Mediterranean setting, bringing together into a single plot both the two main narrative strands of the 12-13th century, the Breton and the Antiquity cycles; the result is an original Southern version of the French chivalric roman. Furthermore, this thematic interest intersects with a remarkable linguistic relevance as the tradition includes witnesses related to two understudied linguistic domains: Franco-Provençal (the third French language, together with the Langue d'Oil and the Langue d'Oc) and Franco-Italian (an artificial literary language). Despite this interest, Florimont has been almost entirely neglected by the scholarly community: only fifteen articles have been published on the subject and the only existing edition (Hilka’s in 1932) is seriously flawed. The project will therefore produce an online multifaceted digital edition, exploiting existing tools for the support of stemmatics and linguistic analysis. Work on this text will then represent an opportunity to reflect on the scholarly status of the digital edition, which is revolutionizing the traditional concept of the edition in the context of Romance Philology. The multidisciplinary character of this research and the planned intensive training focused on Digital Humanities will allow the applicant to present
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Personalized forecasting of prostate cancer growth through advanced nonlinear biomechanical model supported by locally adaptive, locking-free isogeometric methods', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Prostate cancer (PCa) is the second most diagnosed cancer and the fifth leading cause of cancer-related deaths among men worldwide in 2022. However, current clinical practice often remains inadequate with limited individualization, leading to overdiagnosis, overtreatment, and undertreatment. A spatiotemporal biomechanistic model informed by multiparametric magnetic resonance imaging offers a powerful tool to address these challenges. Isogeometric analysis (IGA) and local h-adaptivity further contribute to accurately represent the complex biostructures and capture tumor dynamics. Hence, this technology enables personalized forecasting of PCa growth following its first diagnosis, leading to improved clinical and therapeutic decision-making. However, the existing models of PCa growth present fundamental limitations in predictive accuracy and computational efficiency. In this project, we will address three issues underlying those limitations: a suboptimal adaptive scheme for IGA, susceptibility to numerical locking due to the near-incompressible mechanical behavior of biostructures, and the assumption of linear elasticity. Towards this end, this project will follow a multifaceted approach that includes the integration of truncated hierarchical B-splines to enhance the adaptive IGA scheme, the use of mixed formulations to circumvent the adverse effects of volumetric locking while modeling near-incompressible biological tissues, and the incorporation of geometric and material nonlinearities to improve the accuracy of displacement and stress fields. Through these transformative strategies, the proposed model will represent a substantial step forward in the development of clinically viable predictive digital twins for PCa growth. This project aligns closely with the objectives
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'High-quality Laser-driven Proton beams for multidisciplinary Applications'.

assistant: **Innovation**

Proton accelerators are in significant demand due to their widespread societal applications, for instance clinical cancer therapy, as the protons target deep-seated tumours with negligible damage to the surrounding healthy tissues. High capital and operational costs associated with the conventional accelerators make proton therapy poorly accessible, which has triggered interest in search for affordable alternatives. In this context, proton acceleration employing high power lasers has recently emerged as a promising alternative to the conventional techniques. In addition to their compactness and cost effectiveness, the laser-driven sources deliver high doses in an extremely short-time period (one billionth of the second), offering a unique prospect for radiobiological studies. The key challenge, however, is to overcome broad energy spread and large divergence of the laser-driven proton beams. This project aims to control these shortcomings by employing a novel target arrangement at PW class laser, which can effectively tailor the spatial and spectral profile of the beam at the source, importantly at high repetition rate (1 Hz). Transporting the beams to large distances away from the laser interaction region will be demonstrated by using a system of magnets, as a step towards building dedicated beamlines for multidisciplinary applications. The high-quality proton beams with energies required for therapeutic applications ( > 50MeV) will be deployed, for the first time, in in-vitro radiobiological studies on cancer breast cells at dose rate of ~ 100 Gy/min. The timeliness of the project is underpinned by the on-going developments of high-power laser facilities globally, e.g. the pillars of the pan-European Extreme Light Infrastructure, EPAC (UK), and ZEUS (USA). Notably, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A perturbative approach to model retinal processing of natural scenes'.

assistant: **Objectives**

A major goal of sensory neuroscience is to understand how sensory neurons process natural scenes. Models built from the responses of sensory neurons to simple stimuli do not generalize to predict how complex, natural scene are processed. Even as early as in the retina, this issue is not solved. Deep network models have been proposed to predict the responses of visual neurons to natural stimuli. However, they are still far from being a realistic model of the visual system. First, the sensitivity to perturbations of the stimulus can thus be very different for a deep network model and for our visual system. Second, it is not clear how the model components can be related to actual mechanisms in the brain. Our purpose is to understand how the retina processes natural scenes. We will follow an interdisciplinary approach where we will build realistic deep network models of retinal processing and test them in experiments. We will develop deep network models that can predict ganglion cell responses to natural stimuli, and map the components of these models to specific cell types in the retinal network.  Our project is original because it will use two novel methods, that will be key to achieve our goal. The first one is a novel approach to characterize retinal function, where we will probe the selectivity of the retina to perturbations of natural stimuli. The second one is a novel tool based on 2-photon holographic stimulation to decompose the retinal circuit. They are tailored to address the specific issues of deep networks. Each ganglion cell has a receptive field center, the region of visual space whose stimulation evokes the strongest responses. Our project is divided in three parts. We will first understand how natural images are integrated inside the receptive field center.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Getting the grip on software product support through error prevention measures', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

SimCorp is currently in the final phase of developing a standard treasury management system and a standard pension fund system. To become successful, SimCorp's new standard products will have to meet high expectations from our current and potential customers. It is therefore an urgent business need for SimCorp to be able to manage and control especially our new standard products in the product support phase.In the context of GRIPS, specific objectives include to minimise changes, to ensure that no unintended side-effects are caused by changes and to reduce the number of errors in the software product releases of the baseline projectTHE EXPERIMENTIn GRIPS an experiment is made to improve the software product support process for one of SimCorp's strategic products. Error prevention measures are selected through analysis of weaknesses in current practice. The effect of inserting the selected measures is studied for consecutive product releases over a 12 months period. Weaknesses are identified through a root-cause analysis performed on historic error reports.The experiment is scheduled to begin in August 1997, following an initial preparation phase.EXPECTED IMPACT AND EXPERIENCESimCorp expects the long term effect of the GRIPS project to be an increased credibility in the market as well as an improved ability to overcome the extra support work load caused by increased demand for our products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reading Descartes: A Reassessment of the Shaping and Transmission of Knowledge in the Seventeenth Century' (READESCARTES) targeting Horizon 2020.

assistant: **Abstract**

The objective of this project is to provide the first in-depth study of the handwritten commentaries on the treatises of René Descartes. This study is important because such sources were crucial in shaping the intellectual revolution occurring in Europe during the 17th century, in which Descartes played a foremost role. However, we still do not have a complete grasp of why his ideas were so important to this revolution, because we do not know how his texts were closely read. The key to understand this process of reading and knowledge-building is the analysis of this kind of sources, up to now neglected by historians. Andrea Strazzoni has preliminarily ascertained their crucial role for the reception of Cartesianism while working on two monographs in the history of philosophy and science, making him the ideal researcher for this project. He has assessed the existence of 109 not retrieved items, plus 38 already retrieved ones. These commentaries constitute a body of literature whose complete analysis will be made possible by this project, focused on those authored by the first teachers of Cartesian ideas: Johannes de Raey and Johannes Clauberg. This study is now timely, because it benefits from new directions of investigation: (a) the study of reading and note-taking practices, (b) a transnational approach to the history of thought, (c) the application of digital mapping tools to large amounts of texts. Such approaches are now at the centre of new researches, led at Venice Ca’ Foscari by the applicant’s supervisor, Marco Sgarbi, and by Dirk van Miert at Utrecht, destination of a secondment. The project integrates these approaches in order to pursue its objective along three lines of investigation: (1) the search for uncatalogued handwritten sources, (2) their textual reco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Combining innovative portable VISUAL, ACOUSTIC, MAGNETIC, and NMR methods, with in-situ CHEMICAL diagnostic tools for effective failure assessment and maintenance strategy of RAIL and subway systems'.

assistant: **Concept**

Railways are one of the prime modes of transportation in European Union and as they are closely associated with intensive passenger and cargo transportation, they own high risk in terms of potential loss of human life and damage/destruction of assets. New technologies and stringent safety standards are constantly being introduced, to reduce risks associated with derailments and collisions. A detailed assessment of the defects which emerge both in the rolling stock and the rail infrastructure is essential to apply the correct maintenance strategy. At the same time large span or segmental bridges and tunnels, which are important parts of rail systems are particularly susceptible to deterioration with increasing risk of failure due to often-harsh and aggressive environments, in combination with aging and increasing traffic load. Evidently, efficient maintenance strategies of complex rail systems, which are based on fast and reliable inspection methods, can reduce significantly potential risks and cost. The overall aim of the project is to develop an integrated system of state-of-the-art NDT methodologies to improve risk assessment and failure prediction concerning the integrity and functionality of rail systems, in favour of the participating SMEs. In particular precise Visual and Magnetic ac-Susceptibility methods, for fast and reliable assessment of track failure and damage will be combined with state-of-the-art Acoustic, and Nuclear Magnetic Resonance (NMR) portable devices appropriate for examining the performance of concrete structures, in order to gain critical information concerning the performance, damage risk, and condition monitoring of rail and subway systems. In parallel an innovative chemical tool kit will be developed for in situ chemical analysis measurement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Learning context dependent behavior: neural and synaptic mechanisms' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Understanding how cognitive functions are implemented by biophysical processes in the brain is one of the most important and challenging goals of neuroscience. In the recent years, significant progress has been achieved by developing theoretical models for neural correlates of decision making, working memory, attention and representation of emotional value. These models were based on experimental evidence and they provided us with the basic building blocks for the study of more complex cognitive tasks. Many of such cognitive tasks can be described as context-dependent behavior: while the outcome of most cognitive operations is an association between a sensory stimulus and a motor reaction, this association is in general not unique, but depends on the cognitive context. Indeed the response to the stimulus can depend on the recent history of experiences, the goal, the motivation of the subject, the environment and other factors. The aim of this project is to develop a biologically realistic theoretical framework for context dependent behavior and, in particular, for the formation of the neural representations of the context. We intend to characterize the dynamical properties of the patterns of neural activities that encode the context, understand how they emerge from the temporal contiguity between task relevant events and determine the scaling properties of networks that implement context dependent behavior. The theoretical framework will be used to build a novel model for the formation of context-dependent emotional value of sensory stimuli. The predictions of this model will be confronted with the available experimental data, and will allow us to validate the model. The proposed theoretical studies should lead to the understanding of the general principles underlying t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel role for PGE2 signalling in promoting aged neuromuscular junctions reinnervation and counteracting sarcopenia.' (RestorAGING), addressing dissemination and exploitation.

assistant: **Impact**

Aging is characterised by a progressive decline in muscle mass and force, potentially resulting in the insurgence of sarcopenia. Sarcopenic patients are at an increased risk of falls and fractures, with a concordant decrease in mobility and personal independence. Evidence suggests that key determinants of sarcopenia insurgence are muscle denervation, failure of its reinnervation and degeneration of neuromuscular junctions (NMJ), representing the connection between the nerve and the muscle and essential for muscle function. This MSCA project will inform our understanding on the interplay between prostaglandin signalling and the NMJ in the onset and treatment of sarcopenia. Prostaglandin E2 (PGE2) stimulates tissue regeneration. Its levels are reduced in aged human and mice skeletal muscles due to increased  activity of its degrading enzyme 15- prostaglandin dehydrogenase (15-PGDH). Inhibition of 15-PGDH in aged rodents restores PGE2 concentrations to youthful levels, increasing muscle mass, strength and endurance. However, the mechanisms underlying how 15-PGDH/PGE2 modulation exerts these effects are not well understood. Here, I will show how PGE2 impacts NMJ integrity in mice, establishing if restoration of its signalling restores NMJs innervation progressively lost in aging. My final aim is to determine whether boosting PGE2 levels via 15-PGDH inhibition represents a viable therapeutic strategy to treat sarcopenia. To confirm the relevance of the dysregulated 15-PGDH/PGE2 axis in determining NMJ alterations in humans, I will perform single nuclei RNASeq and spatial proteomics (CODEX) on muscle samples of young and aged healthy, pre-sarcopenic and sarcopenic individuals. I will integrate the molecular data with in-vivo muscle morphology and function, (1) to reveal wheth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multi-level Model Calibration for the Assessment of Historical Masonry Structures', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The MultiCAMS project will develop an advanced computational strategy including numerical modelling and innovative model calibration for realistic assessment of historical unreinforced masonry structures. The presence of relevant historical heritage in Europe, partly still in use, together with high seismic risk in the Mediterranean areas highlights the need of assessing such structures considering current safety requirements and if necessary strengthened to prevent critical failure. The proposed assessment approach is based on the use of models with different levels of sophistication, comprising detailed mesoscale models where masonry units and mortar joints are modelled separately (low level), homogeneous shell/solid-element models in which masonry is considered as a continuum (intermediate level), and efficient macroscale models where entire structural parts (i.e. piers, spandrels) are represented by appropriate macro-elements (high level). In this respect, I will develop a novel numerical description with macro-elements for an efficient and practical analysis of masonry structures accounting for the interaction between the nonlinear in-plane and out-of-plane behaviour of different URM components. An innovative model calibration strategy utilising inverse analysis techniques will thus be developed to couple the efficiency of the novel simplified mechanical model and the accuracy of existing detailed models, such as the parameters of each model will be determined from the inverse analysis of the numerical response of the lower-level model. The main outcome of MultiCAMS will be a comprehensive and accurate methodology for the seismic assessment of historical masonry buildings, which represents an urgent requirement for the safeguard of human lives in many European urba