RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Twinning for Excellence in Research, Training and Innovation in Protein Misfolding Diseases' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Protein misfolding diseases (PMDs) are a large group of human disorders caused by protein misfolding and include serious conditions with high socio-economic impact, such as Alzheimer’s disease, systemic amyloidosis, obesity, cystic fibrosis, retinitis pigmentosa and type 2 diabetes. The vast majority of them remain incurable so there is currently a great need for the development of effective therapeutics against them. Among the >70 known PMDs, about one third occur due to the misfolding of integral membrane proteins (MPs). MPs, however, are notoriously difficult to overexpress, isolate and study, both biochemically and structurally, thus constituting particularly challenging targets for therapeutic intervention with only few lead molecules in (pre)clinical pipelines. Furthermore, the scientific community involved in PMDs remains fragmented, with the majority of research targeting soluble proteins and only a small, rather isolated, sub-community focusing on misfolding-prone MPs. The National Hellenic Research Foundation has been exploiting the power of synthetic biology to develop efficient technologies targeting the misfolding of both soluble and membrane proteins. The coordinator wishes to build on these initial successes to partner with three prominent centers in PMD and synthetic biology research in order to establish a new excellence hub in research, training and innovation in PMDs and consolidate the scientific community in this field. Through this process, it will acquire a position among the leaders in the field of PMDs and converge with the most advanced institutions in terms of the quality of scientific data it produces, number of top-tier of scientific papers it publishes, amount of funding it secures from competitive sources, efficiency with which it trains i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The historical roots of global inequality' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The aim of this project is to understand the historical roots of global inequality. Specifically, it will address two questions: Why did some regions experience an early start in the development of complex hierarchies? How relevant is such an early transition in explaining current comparative economic development. A series of theories, going back to the origins of the social sciences, emphasize the role of some crucial environmental factors, in explaining the rise of the very first complex hierarchies. Unfortunately, however, the scarcity of global datasets on natural environment and hierarchy, going back to the first human societies, has made it difficult to test these theories. Partial empirical validation has come almost exclusively from either cross-sectional empirical studies, using data on the current environment to proxy for past conditions, or case studies focusing on a limited numbers of well-studied areas. This project aims at filling this gap by combining new global panel data on ancient climate (a result of recent advances in paleoclimatology), ancient migrations (reconstructed through archaeogenetics) and ancient societies (constructed from aggregating archaeological reports) with advanced econometric techniques. The project comprises three lines of research. The first line will test a prominent theory that relates a series of changes in the natural environment with the emergence of intensive food storage and the subsequent rise of the first relevant socio-economic inequalities among hunter-gatherers. The second line will focus on farming societies and investigate the role of long-distance trade, spurred by the invention of bronze, on the rise of the first urban civilizations and new unprecedented economic inequalities among farmers. The third line will doc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Networking for excellence in functional pharmacology to study the role of fatty acid metabolism in neurological disorders'.

assistant: **Concept**

The Latvian Institute of Organic Synthesis (LIOS) is in great need to enhance its scientific performance and this could be accomplished through stronger international collaboration within the defined National RIS3 specialization in biomedicine. Latvia is performing well below the EU-average in terms of research excellence and innovation scoreboard. The FAT4BRAIN project builds cooperation between LIOS from the Widening region and world leading partners in translational neuropharmacology (Uppsala University), metabolism and neuropsychiatric imaging research (Eberhard Karls University Tuebingen) as well as innovative mitochondria research company (Oroboros Instruments). The aim of FAT4BRAIN is to establish a network of excellence focused on the pivotal and common role of fatty acid metabolism in the development of neurological disorders, an issue of utmost biomedical and societal interest. FAT4BRAIN will use a multidisciplinary, functional pharmacology approach to promote cutting-edge research in this field. A comprehensive set of activities including workshops, expert meetings and dedicated trainings for early-stage researchers will enhance knowledge-bridging and networking. FAT4BRAIN activities will specifically focus on strengthening capacities in areas that need improvement at LIOS, using the internationally-leading partners’ excellence and experience. Dissemination of results to the research community, industry partners and public through presentations at conferences, media outputs as well as high impact publications will be facilitated by the partners’ extraordinary reputation and high-impact profile. Importantly, the research excellence of the partnering institutions together with the targeted activities of FAT4BRAIN will help LIOS to improve their own research pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Distributed Renewable resources Exploitation in electric grids through Advanced heterarchical Management' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The DREAM project will lay the foundations for a novel heterarchical management approach of complex electrical power grids, providing new mechanisms for consumer involvement in economical and ecological electricity use as well as stable and cost effective integration of distributed renewable resources.Applying the principles of autonomous agent-based systems to the control and management of the electricity distribution grid will allow the system to constantly adjust to current operational conditions and make it robust to exogenous disturbances. In turn, this will allow for greater penetration of intermittent resources and will make the distribution grid more resilient to failures. DREAM will include several layers of controls for normal, congested and post-contingency situations that will use different coordination strategies ranging from market-based transactions to emergency demand response and create ad-hoc federations of agents that will flexibly adjust their hierarchy to current needs.The system will transition smoothly between control layers depending on local operational conditions, so that responses to disturbances will be sized precisely, margins will be used parsimoniously and full network flexibility will be tapped. The system will involve only limited data transfers and no centralized control, promoting extensibility, heterogeneity and easy deployment across countries with different network architectures and hardware manufacturers.DREAM will demonstrate the economic and technical feasibility of these novel control mechanisms thanks to several real-world small-scale pilots dedicated to different use-cases, and computer simulations will be used to study further scalability. Furthermore, economic viability will be model and examined for the various actors in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GaN in One Module Integrated Converter for EP systems' (GaNOMIC).

assistant: **Innovation**

Satellite contractors are permanently looking for cost and performance improvements. This cascades to the PPU, a subsystem having a very high impact on the cost and performance of EP systems.Hence, we propose to focus on the PPU “heart” studying a disruptive power converter, with major innovations complementary to the incremental improvements, beyond the state of the art. We will demonstrate and combine in a synergistic way innovative technologies (such as GaN, digital control, adaptive filtering and embedded packaging), thus resulting in a radical breakthrough applicable to advanced EP architectures based on such PPU designs. The consortium plans to demonstrate the selected technologies by means of a 7.5 kW power converter to be tested in electrical propulsion existing test facilities, thus providing measurable validation, and specification definition, within the 2016 Phase 1 time frame.This will lead to dramatic improvements in cost, mass and volume targeting part list reduction (by 3), converter efficiency (98%) and optimized thermal characteristics (200°C), translating into system optimization and increased power requirements.Being at the forefront of technological developments, the consortium members are able to anticipate emerging technologies and medium to long term performance requirements consistent with existing and planned space programs at national, commercial and ESA levels. GaNOMIC will constitute a solid technical basis for future Direct Drive configurations, and further down the line, to “distributed” configurations where the PPU can be eliminated altogether.In addition to promoting and accelerating the development of breakthrough EP-related concepts, the consortium members have identified other markets, e.g. aeronautics and automotive, which could benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The International Congress on Mathematical Physics' to be submitted under Fifth Framework.

assistant: **Abstract**

The objective of the Congress is to prevent the most important achievements of mathematical physics in the recent period of time and create the opportunity for the effective interdisciplinary flow of information. Besides the canonical domain, (such as equilibrium and nonequilibrium statistical mechanics, condensed matter physics, quantum mechanics and spectral theory, quantum field theory string theory, M theory and duality, general relativity, dynamical systems, nonlinear PDE's and fluid dynamics, operator algebras and noncommutative geometry, quantum chaos and semiclassical approximations), it will include new directions involving research in bio-mathematical-physics and quantum information which are expected to be of crucial technological relevance in the future. it will be an important opportunity for integration of a broad domain of mathematical sciences in European Union and is expected to enable to many researchers to begin new collaborations. A novelty of this Congress will be also a special emphasis on the training of PG students and young researchers. Besides numerous invited lectures by leading scientists in the world, the program will have an extensive public program with lectures by distinguished scientists M. Atiyat, A.Connes, M. Gell - Mann, S. Hawking an d D. Ruelle which, besides other things, should play a special inspirational role to the those beginning their scientific carrier.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00124-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HYBRID RIG FOR DRILLING, WORKOVER AND RE-ENTRY WORK' under Fourth Framework.

assistant: **Concept**

The aim of the project is to provide a hybrid rig and underbalanced/balanced drilling/reentry services at low cost and maximum environmental protection to open more marginal fields in Europe for enhanced oil production from new or old (reentry) fields. The coiled tubing and conventional slim hole technologies will be combined in one drilling rig with reduced manpower on the rig. The application of such a drilling system will permit multiple horizontal wells with extension of the original drainage zone. The hybrid rig will be capable to vertical depth of 2500 m plus a horizontal displacement of 500 m. The need to change rigs for different work will be eliminated.The project is splitted into five phases. The first phase includes the design of key elements of the hybrid drilling rig like drive system, mast with topdrive, substructure, pipehandling, mud system, and the modification of bottom hole assembly components to assure proper interactions between jointed pipe and coiled tubing.The second phase involves the manufacturing of the rig components and composite of existing equipment. Specific coiled tubing drilling bottom hole assembly components and slimhole drillstrings are available.During the third phase (assembly/installation) an initial rig-up including the testing of critical components will be completed prior to starting the full field trial program.The forth phase (commissioning) involves the drilling of 2 pilot wells using both technologies, coiled tubing drilling and drilling with jointed pipe. The objective is to demonstrate the economic and technical viability of the complete system. The fifth and last phase is used for completion of reports and dissemination of results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A revolution in the understanding of the mercury-selenium interaction in biota', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Mercury (Hg) pollution is a major environmental problem. Due to its extreme toxicity, Hg has recently been included in the top ten chemicals of major public health concern by the World Health Organization. Once released in the environment, it can be transformed, principally by aquatic microorganisms, into methylmercury. Methylmercury’s hazardous effects are biomagnified through food webs, resulting in negative health effects. However, Hg metabolic pathways in biota remain poorly understood. Therefore understanding these complex processes is crucial to elucidate potential (eco)toxic effects as well as factors governing Hg biogeochemical cycling. Hg binding with proteins has been evoked as a cause for toxicity and the role of selenium (Se) as antagonist for Hg toxicity is acknowledged but thus far not well understood. SeMER is an ambitious and multidisciplinary research project with a main objective to revolutionize the understanding of Hg metabolic pathways in living organisms in the context of (antagonist) interactions with Se. The project is based on the development of novel analytical approaches that combine speciation and natural isotopic fractionation in a unique pattern. Speciation provides valuable information about reactivity and potential toxicity of metabolites. Furthermore, the natural abundance isotopic signatures add a dynamic dimension, comprising the life history of target elements, pollution sources, and reaction tracking. The resulting (bio)molecular and isotopic signatures will provide valuable insights of Hg in biota and potential detoxification mechanisms. Developed methodologies will be assessed in both freshwater and marine ecosystems in order to characterize important differences in Hg:Se interactions across contrasting habitat types. SeMER concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GNSS DAta Pool for PerFormances PredIction and SimuLation of New AppLications for DevelopERs'.

assistant: **Innovation**

With the increase of criticality level of the GPS applications, products manufacturers and developers are now requesting a relevant mean to predict performances and reliability of their future applications. Often SMEs have ideas that sometimes cannot be implemented because they depend on the availability of data resources or specialised tools that are too expensive to obtain.In this context, GAPFILLER project aims at filling the gap between big manufacturers and SMEs by providing the researchers and developers' community with a unique extensible data pool enabling performances prediction and simulation of new Global Navigation Satellite System (GNSS) based applications and algorithms. GAPFILLER consortium aim is to create quality content and innovative services and to allow people to access and use online content and services across GNSS technologies barriers.The main objective of the GAPFILLER project is to define, build and disseminate a powerful data pool of worldwide GNSS measurements enabling low cost tests campaigns, performances predictions and simulations of new GNSS based applications.Main targeted benefits are:-The development of an innovative use of a common GNSS database for performances assessment that will drastically reduce the cost of tests campaigns and certification process.-The adaptation of the EGNOS aeronautical integrity concept to new application domains that will allow SMEs to gain the know-how for exploiting it and getting competitive advantage.-The knowledge transfer between technology providers/data brokers and content providers (especially SMEs) boosting development speed of EGNOS and GALILEO services.By promoting adoption of EGNOS and emergence of a new data economy related to GALILEO, the consortium will maximize the Return Of Investment of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigation of the Type VI secretion system-associated toxins of Burkholderia thailandensis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Secretion systems are evolved machineries enabling bacteria to deliver toxins and virulence factors, called effectors, into target cells to enable the onset of infectious diseases. Uncovering these effectors is essential for the understanding of bacterial pathogenesis and the establishment of appropriate therapeutic strategies to tackle infectious diseases. The recently identified Type Six Secretion System (T6SS) is conserved in environmental and pathogenic Gram-negative bacteria. The T6SS is an organelle structurally akin to an intracellular and membrane-bound contractile phage tail used for the delivery of toxins into prokaryotic and eukaryotic target cells. The importance of this system in the context of infection is highlighted by its ability to not only target eukaryotic cells during bacterial infection, but additionally to target other bacteria co-infecting mammalian and plant hosts. Despite the recent advances made in understanding the mechanisms underlying the T6SS dynamic, very little is known about the T6SS effectors repertoire used by life-threatening pathogens, such as Burkholderia pseudomallei, and for which, vaccine strategies are currently unavailable. In the proposed research, a combination of high-throughput and cross-disciplinary technologies will be used to uncover and characterise novel T6SS effectors in B. thailandensis, a surrogate organism closely related to B. pseudomallei. This will 1) identify new T6SS effectors targeting eukaryotic cells, using a reporter-based transposon screening and 2)  identify novel T6SS toxins targeting prokaryotic cells, using a genome-wide saturation mutagenesis strategy. The outcomes of the proposed research will identify the key cellular stages hijacked by the T6SS during the infection of a host, while exposing poten