RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of the functional role of microRNAs in the eye' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The eye is a highly specialized organ whose development and function requires a precise coordination and timing of morphogenetic and cell differentiation events. However, in spite of the recent significant advances in the field, also facilitated by the human and the mouse genomic sequencing efforts, the transcriptional control of this complex network of events is still poorly understood. This project aims at gaining further insights into the control of gene expression in eye tissue and cell types, by identifying novel microRNA-mediated mechanisms that may greatly contribute to this complex function. microRNAs are 21-25 nucleotide small RNAs that negatively regulate gene expression. Although several microRNAs are reported to be expressed in ocular tissues, their role in the eye transcriptome is completely unknown. In this project, we aim at the identification, detailed characterization and functional analysis of microRNAs expressed in the non-retinal parts of the eye, such as lens, cornea and ciliary body. In particular, we will select and characterize microRNAs with a presumptive role in eye development and function, by first carrying out detailed expression analysis in mouse by RNA in situ hybridization to establish their spatiotemporal localization. The selected eye-expressed miRNAs will be further evaluated to identify, by bioinformatics approaches, followed by in vitro experimental validation procedures, their putative target genes. Finally, these miRNAs will be analyzed from a functional point of view, by means of overexpression and loss-of-function studies, both using in vitro (cell cultures) and in vivo (medaka) systems. We believe that this effort should lead to a better understanding of the mechanisms controlling gene expression in the eye and may also contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Establishing a European Knowledge and Learning Mechanism to Improve the Policy-Science-Society Interface on Biodiversity and Ecosystem Services' (EKLIPSE) under Horizon 2020.

assistant: **Objectives**

The aim of EKLIPSE is to establish an innovative, light, self-sustainable EU support mechanism for evidence-based policy on biodiversity and ecosystems services open to all relevant knowledge holders and users, and to hand over this mechanism to the wider knowledge community by the end of the project. The mechanism will build on existing science-policy-society interfaces and be further refined via iterative evaluation and learning throughout the project. The mechanism will provide trustworthy evidence for policy and society upon request and will make the knowledge community more able to provide synthesized and timely evidence by providing a platform for mutual learning and engagement. All relevant knowledge holders and users will be actively encouraged and supported by the project team through their individual strengths and interests, thus ensuring targeted contributions. Many institutions have already expressed their interest in the “Network of Networks” of potential contributors to the EU mechanism’s activities. EKLIPSE will directly support the further development of this network and ensure the involvement of relevant stakeholders in the following key areas: (a) jointly developing and setting up a business plan for the mechanism after the end of the project (WP1), (b) conducting joint evidence assessments using established and innovative methods to support policy and societal needs (WP3), (c) jointly identifying research needs and emerging issues (WP4), actively building the Network of Networks and (d) encouraging societal engagement (WP6). This will be supported by an interim governance structure, a strong communication component, including a Science-Policy-Society Forum, and an independent formative evaluation to ensure learning (WP2).


**Keywords:** Support for e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'On electrokinetic material response in marine clays'.

assistant: **Innovation**

The aim of the proposal is to investigate the effect of electrokinetics on the hydro-mechanical behaviour of sensitive marine clays using an innovative combination of techniques from material science, geotechnical engineering and electrical engineering. Two extremes will be experimentally and theoretically investigated: (1) Rapid laboratory testing of marine clays by electrokinetically enhanced consolidation in element testing; (2) Rapid electrokinetic enhancement of the hydraulical and mechanical soil properties for soil improvement. The first case will potentially offer a tenfold decrease of test duration for laboratory tests on marine clays enabling better material characterisation. The second case enables to develop novel new strategies for in situ improvement of marine clays using electrokinetics without detrimental side effects. The traditional geomechanical test setup for testing super-soft soils, such as marine clays, will be adapted for the application of electromechanical loading with multiple inductors of conductive plastic, and the application of static and modulated electrical excitation. The same set of electrodes will be used for the novel application of resistivity and capacitive sensing measurements of the soil properties. This will allow optimizing the electrokinetic method for rapid soft soil improvement and the rapid testing of soft soils in laboratory tests. The effect of the electrical excitation on the fundamental soil properties will be probed on the micro-scale using Fourier Raman Spectroscopy. Finally, the acquired fundamental insight of the material response will be used as basis for new continuum models, addressing the electrokinetic effects in the formulation, and validation of these models for the tested marine clays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Sensors for monitoring water pollution from contaminated land, landfills and sediments'.

assistant: **Concept**

The overall objective is to enhance the development of chemical sensors, biosensors and bio mimetic systems for practical applications in the abatement of water pollution from contaminated land, landfills and sediment. The aim is to provide in site" monitoring of environmental pollutants in water and contaminated soil and sediments, to facilitate optimisation of remediation technologies and natural attenuation processes. The proposed work programme is based on a series of European meetings, a centralised information facility and a broad collaboration programme. SENSPOL will cluster the sensor development activities in the EU's environmental projects and act as a catalyst for the advancement of European technology for monitoring the environment. Paths will be identified to resolve the most effective sensor systems for use in monitoring multiple pollutants contaminating water, soil and sediments and for use in site management in order to protect ground and surface water from pollution."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Early Cenozoic Asian Monsoons: Mechanisms and Evolution Through Time' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Asian Monsoon is primarily driven by continent-ocean thermal contrasts, and frequent hydro-meteorological extreme events emphasize that it is affected by recent global climate change in response to increasing atmospheric level of carbon dioxide (pCO2). The medium and longer-timescale effects of circulation changes in the monsoon system control precipitation in continental Asia and, in the past, shaped Eurasian paleoenvironments and biotic evolution. The Asian monsoons have long been thought to have originated ~23 Million years ago, driven by regional uplift. However, recent studies have shown that the monsoons are millions of years more ancient than previously thought and were regionally similar to today during the high pCO2 Eocene Greenhouse episode. These studies open a vast array of new questions: (1) How did these early monsoons evolve through the Eocene? (2) How did they react to the numerous, short-term hyperthermal and hypothermal pCO2 events that ruled this period? This research project proposes to address these issues by focusing on three key sedimentary records in the Eocene monsoonal realm: in China, Myanmar, and Turkey. After refining the local stratigraphy through U/Pb geochronology of volcanic deposits, the three records will be investigated with respect to different geochemical and mineralogical paleoclimatic proxies. Elemental geochemistry and clay mineralogy will help to understand the evolution of seasonality and precipitation; stable and clumped isotope analyses on pedogenic carbonates and soil organic matter will document past rainfall amount, temperature and pCO2 variations; U/Pb dating on aeolian dust deposits will allow the reconstruction of past wind patterns. The resulting findings will document the short- and long-term variations of the mon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Structure and Properties of Materials at High Pressure' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The Bayerisches Geoinstitut is a research institute dedicated to investigating the physical and chemical properties of materials at extreme conditions of pressure and temperature. Although the main aim of the institute is to understand the composition, structure and dynamics of the Earth's interior, research directions overlap significantly with the fields of solid-state physics and chemistry and material science. The institute is equipped with a wide range of high-pressure experimental apparatus for synthesis, phase equilibrium and in-site studies as well as for characterising the composition, structure and properties of materials, both in-site and at ambient conditions. Facilities include a high-pressure laboratory, equipped with 4 multi anvil presses (25 Gap, 3000 K), which is unique worldwide. The diamond anvil cell facilities, which are also unique world-wide, offer a broad range of techniques including laser and external heating (150 Gap, >4000 K), in-site X-ray diffraction (ultra-high intensity source with area detector), single-crystal X-ray diffraction, in-site spectroscopy (e.g. IR, Raman, and Moss Bauer) and in-site ultrasonic (gigahertz interferometer). Other facilities include piston-cylinder and hydrothermal high-pressure laboratories, deformation apparatus, calorimeter, high-resolution transmission and scanning electron microscopes, electron microprobes, ultrasonic interferometers and electrical impedance analyser. In addition, expertise and computer facilities are available for calculating the structure and properties of materials at extreme conditions from first principles, an area that is complementary to experimental studies. Users will have access to the experimental and computational facilities and will receive full scientific training and technical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Extremely fast silicon transistor based on carrier velocity modulation' in the context of a Fifth Framework call.

assistant: **Objectives**

The current trend in microelectronics is the high end silicon devices and circuits will be processed on wafers with a very thin silicon-on-insulator (SOI) layer. In this project the feasibility to realise a novel, extremely fast silicon transistor based on carrier velocity modulation will be investigated. These SOI velocity modulation transistor (VMT) may have intrinsic and extrinsic operation speed of several hundreds of GHz. The SOI VMT can replace high speed 3-5- transistors, e.g., in telecommunication and automotive radar applications.OBJECTIVESThe objectives in this work are to:1) Realise a dual gate velocity modulation transistor on ultra-thin SOI substrate;2) Experimentally and theoretically define the optimum operation point for velocity modulation switching;3) Perform Monte Carlo simulations on transport and switching properties of a velocity modulation transistor realised on substrates with ultra-thin SOI films.DESCRIPTION OF WORKThe work includes the following tasks:- Device fabrication: The test structures and devices will be fabricated on thin SOI wafers. The process includes fabrication of thin SOI wafers with highly doped handle wafers for back gating and device processing on the wafers. For structural characterisation ultra-thin SOI films can be realised by thermal oxidation and stripping the sacrificial oxide;- Structural characterisation: The devices structures will be characterised using XDR, AFM, HRSEM and TEM;- Transport measurements: The electrical characteristics of the VMT structures will be studied using field effect mobility measurements and low temperature Hall measurements. For AC measurements, a set-up up to 110 GHz is available;- Modelling and theoretical aspects: The VMT devices will be simulated using one particle and ensemble Monte Carlo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exoplanets and Early Earth Atmospheric Research: THeories and Simulations' (E3ARTHS).

assistant: **Concept**

This program is dedicated to the simulation and characterization of Extrasolar Terrestrial Planet (ETP) atmospheres. Thanks to new generation codes, the team E3ARTHS aims to provide a top expertise in a key domain of astrobiology: the origin, evolution and identification of habitable worlds, and the quest for biomarkers on Earth-like planets. The team will also revisit early Earth models for a better understanding of the context of the origins of life, in the light of recent works on Earth formation, impact history and Solar evolution. The observable signatures of an ETP and its ability to sustain life are determined by atmospheric properties: chemistry, radiative transfer, climate. Although these processes are usually treated separately, they evolve in a tightly coupled scheme under the influence of astrophysical, geophysical and, if present, biological mechanisms. Eventually, realistic planetary environments will thus have to be modeled with self-consistent 3D tools, involving a multidisciplinary and international approach. Although ambitious by today's standards, such enterprise is a necessary counterpart of the planned ETP searches, and is required to study the discovered planets. Observatories like Darwin/TPF and ELTs will provide direct information on ETPs within 10-15 years. Ongoing transit searches (CoRoT, and Kepler), and radial-velocity surveys, are on the verge of detecting ETPs. In this context, E3ARTHS can become one of the cores in European theoretical research on ETPs, in close interaction with observation programs. Since his PhD, F. Selsis has developed his own research on ETPs, which already had important implications for the design of instruments for TEP search and characterization. His plan is now to take this research at the next level by creating a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Modelling human pre-leukemic syndrome in mice: functional dissection of the 5q31 candidate region'.

assistant: **Innovation**

The goal of this project is to develop novel expression systems and mutant transgenic organisms, in order to gain insights into the role of the 5q31 region, revealing the functions of genes involved in haematopoiesis and the leukaemia processes. To this end, we will model aspects of the pre-leukemic 5q- deletion-mutation syndrome in the mouse, by using a series of homologous recombination and novel expression systems strategies. More specifically, based on a previously successful technological approach, we plan to 1) delete in the mouse the synthetic candidate 'critical region' between the GM-CSF /IL3 and TCF1 genes, included in our constructed human YAC contig. Our approach will utilize the Cre-IoxP recombination system combined with conditional targeting, to induce the deletion of the 5q31 region in the adult mouse myeloid cells only (like in humans), by linking the Cre recombines gene, under the myeloid and adult-specific promoter of the myeloperoxidase gene. Thus, the generated animal models containing precise large chromosomal deletions, occurring as acquired somatic mutations, will accurately mimic the human pre-leukaemia syndrome 2) Systematically analyse the resulting phenotypes of the mice by differential display technology approaches, to reveal the deregulated pathways and gene networks occurring in these models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel mechanisms of early defense against virus infections'.

assistant: **Objectives**

Virus-induced type I interferons (IFN) have classically been considered to constitute the first line of defense against virus infections However, recent work by us and others has identified early antiviral actions that occur independently of inducible type I and III IFN expression and sometimes even prior to IFN action (e.g. Iversen,...., Paludan. Nature Immunology, 2016; Paludan. Trends in Immunology, 2016). These discoveries challenge the current thinking in the field that IFNs constitute the first line of defense. Hence, there is an urgent need for more detailed understanding of the immediate antiviral defense mechanisms. Most importantly, we remain to identify key players in IFN-independent antiviral responses, we completely lack insight into the mechanisms that govern these responses, and we also lack information on the importance of this layer of defense in mice and humans. In accord with this, my proposal follows four aims: (i) Identification of mechanisms of virus detection at epithelial surfaces, (ii) elucidation of the role of tonic IFN signaling in antiviral defense, (iii) identification and characterization of novel restriction factors, and (iv) deciphering the mechanisms that govern induction of the first wave of IFNs at epithelial surfaces. In addition, I will also explore the interactions between the early antiviral actions. To achieve the goals, I will combine unbiased genome-wide screens with hypothesis-driven approaches, and will integrate molecular biology/genetics/biochemistry with advanced cell culture systems, animal science and analysis of patient material. Strong preliminary data have been generated for all four aims, and world-leading collaborations are in place, hence minimizing the risks, and allowing fast progress. Our findings will (i) chang