RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Siglecs as mediators of the pancreatic cellular crosstalk in diabetes'.

assistant: **Objectives**

The mechanisms of the immune and endocrine cell interaction within the islet and resulting β-cell death arehighly complex and largely unknown. To investigate the cellular crosstalk in the pancreas and how itsdisturbance leads to insufficient insulin production is important to understand the pathology of the disease. Thisis the major goal of this project.Activation of inflammation is not only a trigger for β-cell destruction, but also a major factor for the metabolicsyndrome, including insulin resistance and complications of diabetes.Signalling and activation of immune cells is facilitated by secreted pro-inflammatory stimulators and via cell-cellinteractions. I propose that a group of adhesion and signalling molecules, the Siglecs (sialic acid–bindingimmunoglobulin (Ig)-like lectins) mediate such interactions. They are responsible for immune system activationand have been initially found in cells of hematopoietic origin. I made the groundbreaking observation of celltype specific Siglec expression in the human pancreas: Siglecs were differentially expressed in glucagonproducing α-cells, and in insulin producing β-cells. A diabetic milieu had an inductive effect on Siglecexpression in the α-cells, but lead to decreased β-cell specific Siglecs. This loss of Siglecs in the β-cell could bedetrimental and result in an excessive cytokine release and in turn switches on Siglec responses in neighbouringcells. In my proposed studies I will investigate the role of Siglecs in the cellular network in islets and in thecirculation to probe whether changes in Siglec expression are causative in the development of diabetes.My project is a pioneer and multidisciplinary study combining the current knowledge of glycobiochemistryand β-cell biology in diabetes. The project uses multi-model ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Enhancing security of digital property rights and citizens’ awareness through an innovative anti-piracy framework of digital content based on Machine Learning and Artificial Intelligence'.

assistant: **Innovation**

Digital piracy and counterfeit activity causes incredible economic damages in creative & e-commerce sectors. It jeopardizes the rights of all creative individuals, puts jobs at risks, and undermines new legal business models and distribution platforms. Piracy and counterfeiting the statistic losses sum $125 billion and 2.5 million of jobs. Part of those loss are transformed into benefits to those who break the law and rights. Consumer is not property aware of such impact.3antS aims to become the main reference cyber-security service framework to fight against contents piracy & digital distribution of counterfeited goods. , 3ANTS mission is to deliver a set of breakthrough cybersecurity SaaS services built over a disruptive self-developed algorithm based on machine learning techniques, that follows as a crawler pirated content & goods through the internet (web, torrents, mobile applications, social networks, e-commerce etc) automatically geo-locating (100% accuracy) the items and forcing their withdrawal (98%)3antS - over this unique technology –provides a framework of an innovative set of added value SaaS services as a response to the business challenges and opportunities: (1)SaaS to remove specific pirated content & goods (2)Smart Analysis & Reports Scorecard to Support Decision Taken (3)Gamification mobile applications to raise awareness, and engage content public targets against the pirate fighting (4)APIs to allow third parties data entrance or developing of new services over it.3ants has gone through processes of “design thinking” and “customer discovery & validation” - with more than 31 million of contents removed, having demonstrated the value proposal with reference entities in the media sector as WarnerBros or SonyPictures (TRL7)3ants aims to scale-up the produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development of a tendon/ligament substitute through bioprinting'.

assistant: **Concept**

Tendon/ligament (T/L) injury is a common clinical problem that can dramatically affect a patient’s quality of life. The native structure of T/L makes them have limited ability to self-repair. Current approaches for T/L substitutes include autografts, allografts and artificial prostheses although their mechanical limitations and/or the induced adverse immune responses have restricted their use, which have accelerated the development of tissue engineering strategies. However, to the date, no clinical long-standing acceptable T/L substitute is available. For this reason, the project’s overall objective is developing an innovative T/L replacement that results in a fully regenerated living tissue, mimicking the natural structure and function and with long-term viability. The unexplored approach that we want take advantage of is through 3D bioprinting and mechano-magnetic stimulation. The use of bioprinting technologies will allow to replicate the tissue structure and together with mechano-magnetic stimulation will induce cell and fibre alignment, that have been shown to induce tenogenic differentiation. Hybrid collagen-silk fibroin scaffolds will be designed and bioprinted to satisfy the mechanical and biological properties needed for T/L substitutes. Mechanical stimulation will be achieved by the inclusion of magnetic nanoparticles in the scaffolds and the use of magnetic forces. Tissue-like constructs will be tested for its mechanical properties and its capacity to induce tenogenic differentiation of human adipose derived stem cells (hASCs), prior to an in vivo assay. This proposal combines the use of bioprinting and magnetic nanoparticles in a bright and new option to create T/L substitutes. Taking into account that hASCs can be easily harvested and expanded from autologo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mixed-phase clouds and climate (MC2) – from process-level understanding to large-scale impacts' (MC2).

assistant: **Concept**

The importance of mixed-phase clouds (i.e. clouds in which liquid and ice may co-exist) for weather and climate has become increasingly evident in recent years. We now know that a majority of the precipitation reaching Earth’s surface originates from mixed-phase clouds, and the way cloud phase changes under global warming has emerged as a critically important climate feedback. Atmospheric aerosols may also have affected climate via mixed-phase clouds, but the magnitude and even sign of this effect is currently unknown. Satellite observations have recently revealed that cloud phase is misrepresented in global climate models (GCMs), suggesting systematic GCM biases in precipitation formation and cloud-climate feedbacks. Such biases give us reason to doubt GCM projections of the climate response to CO2 increases, or to changing atmospheric aerosol loadings. This proposal seeks to address the above issues, through a multi-angle and multi-tool approach: (i) By conducting field measurements of cloud phase at mid- and high latitudes, we seek to identify the small-scale structure of mixed-phase clouds. (ii) Large-eddy simulations will then be employed to identify the underlying physics responsible for the observed structures, and the field measurements will provide case studies for regional cloud-resolving modelling in order to test and revise state-of-the-art cloud microphysics parameterizations. (iii) GCMs, with revised microphysics parameterizations, will be confronted with cloud phase constraints available from space. (iv) Finally, the same GCMs will be used to re-evaluate the climate impact of mixed-phase clouds in terms of their contribution to climate forcings and feedbacks. Through this synergistic combination of tools for a multi-scale study of mixed-phase clouds, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Integron Cassette Dynamics and the Integrase Gene Expression', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Bacterial antimicrobial resistance has become one of the major concerns in modern medicine. It is currently responsible in Europe for 15 times as many deaths as AIDS every year. Not surprisingly this phenomenon is one of the Top Six Health Topics for the eCDC.Bacteria have shown a remarkable evolvability towards resistance. One of the most worrisome mechanisms observed, is the integron, a highly efficient gene-recruitment platform. In addition to rising resistance, there are no encouraging perspectives in the drug discovery field. Thus, containment is the major asset in combating resistance. Nevertheless new and creative approaches are being assessed. A good example is the study of molecules against the integrase. A deep knowledge on the integrase’s activity and its regulation is at the basis of any major achievements in the field.This project aims to better understand integrons and to acquire new knowledge that will ultimately help combat antimicrobial resistance. The first set of experiments will unravel the behaviour of integrons in vivo. By developing a mouse model, we will study the influence of antibiotic therapy in the integrase induction through SOS response in the gut. Further work will be focused on the in vivo integron/plasmid synergy, as single stranded DNA transmission during conjugation can trigger integrase activation in vitro through SOS response. Such interaction is especially worrisome as many resistance plasmids carry resistance integrons.This data will help understand the behaviour of integrons and the dynamics of integrases in their natural environment.Altogether, the results of this project will mean a breakthrough in understanding the evolutionary potential integrons confer to bacteria. This knowledge will definitely help develop efficient tools t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VIRtual Team User Environment' (VIRTUE) targeting Fifth Framework.

assistant: **Abstract**

You are at a meeting table with people spaced around in front of you. You are able to communicate with them effectively as if they are sitting next to you in the same room, in fact you are led to believe they are present in the same room - but they are actually located at several remote locations. For many types of meeting this high-realism telepresence conferencing system will replace the need to travel. Technologies in computer vision and graphics have developed to a position where this vision is achievable. VIRTUE will make this happen in Europe. Achieving this vision will require practical and efficient solutions to technology issues, most importantly wide viewpoint synthesis from multiple cameras that deals with occlusion, and object segmentation from non-uniform backgrounds. A comprehensive set of user experiments will ensure the result is an empirically validated demonstrator. You are at a meeting table with people spaced around in front of you. You are able to communicate with them effectively as if they are sitting next to you in the same room, in fact you are led to believe they are present in the same room - but they are actually located at several remote locations. For many types of meeting this high-realism telepresence conferencing system will replace the need to travel. Technologies in computer vision and graphics have developed to a position where this vision is achievable. VIRTUE will make this happen in Europe. Achieving this vision will require practical and efficient solutions to technology issues, most importantly wide viewpoint synthesis from multiple cameras that deals with occlusion, and object segmentation from non-uniform backgrounds. A comprehensive set of user experiments will ensure the result is an empirically validated demonstrator.OBJECTI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Business Innovation Support Network for the Czech Republic – Enhancing the innovation management capacities of SMEs by EEN in 2015-2016' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall aim of the project is to elaborate on experience with the preceding project “Enhancing the innovation management capacity of SME's” conducted by the Enterprise Europe Network in the Czech Republic in the second half of 2014 and to offer Czech SMEs with significant innovation activities, in particular to the beneficiaries of the  SME Instrument, consecutive services in 2015-16. The activities of the project deal with the lack of quality and affordable services for SMEs in the area of innovation management in the Czech Republic and the lack of innovation management capacity in Czech SMEs. In particular, the project aims: 1) run the standardised support system for beneficiaries of the SME Instrument under Horizon 2020, and 2) identify, through the analysis of innovation management capacity of SMEs with significant innovation activities, weaknesses of the innovation management system in the SME and offer measures to their elimination. In order to meet the objectives of item 1, all the beneficiaries of the SME Instrument under Horizon 2020 will be contacted by experienced Key Account Managers upon notification from EASME. Key Account Managers will meet in person with relevant representatives of the beneficiaries in order to describe the full scope of the support offered, and ask for confirmation to proceed with the identification of growth opportunities and setting up the coaching service process, which they will mediate. In the process fulfilling the item 2, small and medium sized enterprises with significant innovation activities and a high potential for internationalisation will be identified by consortium members and their EEN partners as well as external partners. Selected SMEs will be offered comprehensive seven-day service packages, including the innovatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rear Fuselage and Empennage Flow Investigation (REMFI)' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

It is known that business needs are placing an ever-increasing demand on the aeronautics industry to develop and manufacture aircraft at lower costs, with improved flight capabilities and a reduced impact on the environment. Hence, a primary objective for the aerospace industry is to offer products that not only meet the operating criteria but also significantly reduce the direct operating costs. Furthermore, research effort with respect to an improved understanding of the flow physics around fuselage / tail combinations remained limited, as investigations naturally concentrated on the wing and its interaction with the fuselage. However, a successful design approach towards the development of modern transport aircraft has to take the empennage as well. Thus, the improvements to be achieved by REMFI focus on three main aspects, the enhanced understanding of the tail flow physics, improved computational predictions for fuselage/tail design and analysis and improved experimental capabilities and measuring techniques for tail flows. This aims at providing means to: - Increase the empennage aerodynamic efficiency and reduce loads - Improve flight safety - improved empennage performance and weight for optimised gaps effects, including Reynolds number effects - Investigate sting mounting arrangement effects on empennage wind tunnel measurements - Enhance the current scaling methodologies to free-flight conditions - Reduce fuel burn (this has a positive effect on energy saving and reduction of emissions to the environment) - Novel design concepts for integrated fuselage / empennage designs with significant interaction between rear fuselage and belly fairing - Investigate novel flow control devices (speed brakes) on fuselage and vertical tail - Shorten the design cycle - Reduce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pharmacological safety testing in human adult stem cell-derived organoids' (TOXANOID).

assistant: **Innovation**

Toxicology and pharmacology assays are crucial pillars of modern drug development. They are essential to understand how tissues such as intestine and liver take up and degrade pharmaceutically active compounds. Due to the lack of suitable in vitro systems, these assays are carried out in experimental animals. This practice increases cost and development time but also creates significant ethical issues. We recently developed a 3D culture system that allows us to expand human tissue stem cells from intestine and liver as organoids and differentiate them to the respective functional adult tissue in vitro. These stem cell-derived tissues show high cytochrome activity and are able to metabolize drugs in a simple and cost-effective in vitro assay. With support from the ERC Proof of concept grant we aim to prove that our technology can outperform current in vitro systems and replace a significant portion of animal-based toxicology studies. This technological advance will lead to substantial reduction of cost in industrial and academic drug development and overcome practical and ethical pitfalls in animal-based testing.To this end we will develop an organoid-based assay to test tissue-drug interactions in three steps:1) Definition of optimal parameters for human in vitro assays to assess gastro-intestinal and hepatic toxicity 2) Scale-up3) Technology transfer and commercial distribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated System Analysis of Urban Vegetation and Agriculture' (URBAG).

assistant: **Innovation**

This research aims to find out how urban green infrastructures can be most efficient in contributing to urban sustainability. This will evaluate which combinations of urban, peri-urban agriculture and green spaces result in the best performance in terms of local and global environmental impact.For this purpose, I will use novel and comprehensive analysis that will integrate the life cycle impacts of the resources required for green infrastructures with the understanding of how green infrastructures impact the urban atmosphere interaction. This comprehensive approach allows to capture the urban metabolism to optimize the food-energy-water nexus. In previous works, the impacts had been only studied individually. The analysis will consist of   1) A geo-referenced land-use model to optimize urban and peri-urban food production in terms of nutrients, water, and energy, considering urban morphology and determining life cycle impacts 2) A spatially-temporally resolved framework for quantitative analysis and simulation of green infrastructures to determine the direct and indirect effects on the urban and regional atmosphere. The research will be implemented in two selected cities with different profiles, Barcelona and Oslo.  The study ambitions to gather substantial quantitative evidence in green infrastructures and sustainability, contributing to cover the existing gap in previous works. This project and the envisaged: Green infrastructures - A Guide for city planners and policy makers, are timely and urgent. Many cities are implementing green infrastructures despite having little quantitative and comprehensive knowledge as to which infrastructure strategies are more effective in promoting food production, air quality and temperature while reducing environmental impact. This i