RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innate lymphoid cells and tissue adaptation to changing metabolic needs' in the context of a Horizon Europe call.

assistant: **Objectives**

Border surfaces of vertebrate organisms are in constant exchange with their habitat. Host cell networks consisting of epithelial cells, stroma and tissue-resident immune cells continuously integrate signals from the environment, a process by which an organism becomes better suited to its habitat (i.e., adaptation). Our understanding of the molecular underpinnings of such homeostatic processes is in its infancy, yet they are decisive for proper organ function. Recently, we and others have identified homeostatic circuitry involving tissue-resident immune cells in the small intestine facilitating adaptation to changes in nutrient cargo. The goal of my laboratory is to capture these molecular networks and to investigate how their failure predisposes to diseases. This proposal aims to systematically define the role of mucosa-associated group 3 innate lymphoid cells (ILC3) and of the IL-22:IL-22BP module in tissue adaptation to changes in metabolic need via their interaction with intestinal stem cells, stromal cells and enteroendocrine cells (EEC). Answering these questions demands both focused and global experimental approaches as well as the use of new genetic models for targeting of ILC3 and for recording epithelial cell differentiation. Based on these considerations and on strong preliminary data, we have devised 3 Specific Aims that will allow an unprecedented analysis of ILC3-controlled tissue adaptation: (1) to understand intestinal ILC3-epithelial cell units regulating nutrient handling and systemic metabolism, (2) to test the role of ILC3 in intestinal adaptation to increased metabolic demand during pregnancy, and (3) to characterize a new immune-epithelial module consisting of EEC and IL-22-producing ILC3. We and others have demonstrated that ILC3 effector programs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An evolution-focused platform for cancer drug discovery', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Solid tumours frequently develop resistance to therapies, leading to treatment failure. This resistance arises from the complex interplay between heterogeneous cancer cell populations and their microenvironment, driving tumour evolution and local adaptation. Current drug discovery pipelines fall short in addressing this complexity. In this ERC-PoC, we will develop EVOaware, a groundbreaking platform that integrates genome editing, spatial barcoding, high-throughput drug screening, multimodal spatial omics, and spatial pattern analysis, to address the critical challenge of therapeutic resistance in cancer from the lens of evolution. Ultimately, EVOaware will accelerate the discovery and development of novel cancer therapies, leading to improved patient outcomes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Frictional shear crack dynamics along heterogeneous interfaces' under Seventh Framework.

assistant: **Concept**

The main objective of the proposal is to offer the best possibe integration conditions to an outstanding young researcher in its new institution. Dr. Scheibert, who is an internationally recognized expert in the physics of friction and fracture, has just received a permanent research position in French CNRS, and has been affected to the Laboratory of Tribology and Dynamics of Systems at Ecole Centrale Lyon. There, he aims at setting up and manage his own research group dedicated to the experimental study of the dynamics of shear cracks along heterogeneous frictional interfaces with an original and multidisciplinary approach.The main methods to be applied are highly controlled model experiments on the frictional contact between an elastomer and a rigid substrate. The dynamics of the slip field over the whole interface will be monitored optically using high speed camera acquisition and a digital image correlation method developed by Dr. Scheibert. The role of both (i) the mesoscopic heterogeneities induced by the geometry and loading and (ii) the smale scale surface disorder on the nucleation, propagation and arrest of micro-slip fronts will be studied in details. The experimental data will be compared with continuum and discrete modelling, in particular with simulations performed by the former group of Dr. Scheibert in the University of Oslo. The objective is to provide a comprehensive picture of friction at all scales and use it to solve important practical problems in a variety of fields including mechanical engineering, geology, biology and robotics.This project, by providing Dr. Scheibert with excellent career perspectives, is expected to stabilize a productive and promising activity on friction and fracture in Europe, as well as to strengthen existing and promote ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable Nanocellulose and Amyloid-Based Materials for Biodegradable Packaging and Smart Agricultural Applications' (SUSNAMU) under Horizon Europe.

assistant: **Objectives**

Nanocellulose and beta-amyloids proteins derived from waste byproducts, such as banana pseudostems, palm oil empty fruit bunches, discarded milk, and tofu production residues, will be used to fabricate films as alternatives to conventional plastics. These films will be produced using casting and electrospinning techniques, combined with other natural biopolymers, including lignin, metal-organic frameworks (MOFs), and bioadditives.  Films will be surface engineered with the spray layer by layer technique for the precise control of their surface properties.The films will serve applications in both food packaging and agriculture. For agricultural use, mulch and greenhouse cover films will be designed to exhibit selective gas transport, controlled sunlight transparency, and limited water permeability. Additionally, they will be engineered to release carbon dots infused with nutrients and pesticides into the soil, aiming to improve crop yields and reduce weed colonization. In food packaging, advanced bioelectronics will be integrated to detect pH changes indicative of food spoilage. The inclusion of anthocyanins and photosensitizers will impart antibacterial properties to the films. Smart strategies will be employed to extend the shelf life of packaged food. Furthermore, artificial intelligence (AI) will be utilized to optimize material properties for enhanced performance.The films will be scaled up in a pilot plant and tested in agricultural fields and packaging applications. To achieve the ambitious goals of SUSNAMU—replacing fossil-based plastics in packaging and agriculture while mitigating global microplastic contamination—a diverse global consortium has been assembled. This consortium spans Europe (Germany, Croatia, Spain, Italy, UK), Latin America (Argentina, Brazil,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MAGTEST: Simple and specific next generation lab-on-a-chip in-vitro molecular diagnostic device' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Antimicrobial resistances are a clear and present danger for human health. More than ever, it is fundamental to have an accurate and fast bacteria identification tool to ensure the judicious deployment of antibiotics.Current diagnostic solutions are either too complex and bulky to operate “on site”, or are simply not informative enough. Magnomics novel, fast, award winning proprietary technology is able to detect bacterial DNA using a simple, compact platform. This fully portable, easy to use in-vitro molecular diagnostic device addresses the concerns expressed by the European Commission with regards to antimicrobial resistances: it allows for the easy and convenient detection of bacteria in any substrate, significantly reducing the lead time for treatments.In line with the expected impact of the “SMEInst-07-2016-2017” topic, Magnomics will initially focus on animal health diagnostics. This choice of market, worth €2.6bn in 2013 with an 8% growth estimated till 2018, was fully validated after winning the Innovation Award at the Kansas City Animal Health Investment Forum in 2015. Addressing a devastating disease in dairy farms across the world that is crushing the margins of milk producers in the EU, the first product will target bovine mastitis, an infection of the mammary gland of dairy cows with an annual economic impact of over €2bn in the EU alone.This technology is expected to significantly boost the competitiveness of the dairy industry through the reduction of health-related hindrances to production. In parallel, the milk production businesses will become more sustainable through the introduction of a high-end biotechnology process within their industrial pipeline, ensuring the efficient use of resources. MAGTEST will allow the company to fully assess the market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COllaborative Consortium for the early detection of LIver CANcer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Hepatitis B (HBV) and C virus (HCV) are the most important etiologic agents of Hepatocellular carcinoma (HCC), which is the second leading cause of tumour related death in the world. The burden of HCC in developing countries represents a major challenge in global public health for the oncoming decades. Clinically, HCC patients have a very poor prognosis and high 5-year mortality rate except when detected early. As a result, HCC early detection is a critical parameter to anticipate the initiation of a tumour process, but affordable and discriminant diagnostic tools are lacking. A consortium of European and Third Countries institutions (Peru and Laos) gathered within the project COCLICAN proposes to tackle this issue through the analysis of metabolomics serum profiles of a large cohort of HBV-HBC infected patients to delineate a bunch of molecules predictive of the emergence of liver cancer. The performance of a low-cost and open-source echo-stethoscope connected to a smartphone will also be assessed, to allow early detection of tumorogenesis in health care underserved areas. This will be possible, thanks to the construction of a sustainable scientific and academic network of engineers, researchers and clinicians mobilised to exchange expertise, skills, technologies, biological material, deployed in three continents: Europe, South America and Asia. COCLICAN has been designed to improve research collaborations, to reinforce capacities, to enhance knowledge of partners and students involved in the project, but also to raise awareness of policy makers and to participate to the innovation potential improvement at the European and global levels. COCLICAN will therefore respond to the health needs of left behind populations, all around the world.


**Keywords:** Liver cancer, h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DEMONSTRATION OF THE UTILISATION OF MEGAWATT TURBINES IN REMOTE AREAS' (1994-1998).

assistant: **Concept**

The proposal is the installation of two Megawatt wind turbines (Nedwind N 53) in a remote area and the operation on a weak grid in Ireland. The wind turbines shall be equipped with a locally built concrete tower and a special lifting device for rotor and nacelle. New design of foundations.This technology is designed especially for erecting the turbines without heavy mobile cranes. The mean annual wind speed at the site is 7.5m/s in 40m height.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Connecting the activities of c-Myc in genome regulation, cellular growth control and oncogenesis' (MYCNEXT) under Seventh Framework.

assistant: **Objectives**

The c-myc proto-oncogene is a general driving force in cancer. The cmyc product (Myc) is a transcription factor that binds thousands of genomic loci. However, the identity of the Myc-target genes that influence tumor development, as well as the mechanisms through which Myc acts on these genes, remain most elusive questions in the field. We will use next-generation DNA sequencing to create a multi-layered set of genome-wide profiles. We will analyze cultured mouse cells and developing tumors, the latter in a transgenic model of Myc-induced lymphoma. The profiles will include (i.) quantitative mapping of the RNA transcriptome (coding, non-coding and small RNAs), (ii.) protein-DNA interaction profiles, (iii.) epigenome profiling, (iv.) 3D-folding of genomic DNA, (v.) mutational analysis. These datasets will provide broad views and will answer pointed questions about the action of Myc. We will address the hypothesis that many Myc target genes may not be regulated at the level of net mRNA accumulation, but rather of co-transcriptional processing events. We will provide maps for the RNA-Polymerase II complex, transcriptional co-factors and histone-modifying enzymes. We will whether the Myc-binding sites that do not map within promoters may act as enhancers and/or replication origins. We will address the hypothesis that Myc contributes to reprogramming of the genome independently from its localized effects on target genes. We will also ask which genes are targets of mutations and/or epigenetic silencing in Myc-induced lymphoma. High-throughput functional genomics will be used to address which genes suppress or promote Myc-induced lymphoma. Altogether, our data will provide an unprecedented level of insight into Myc function and into the early stages of tumor progression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'How do cells form an embryo: Intracellular, temporal, and phenotypic dissection of mammalian gastrulation' (EmbryoCellEnsemble).

assistant: **Innovation**

In multicellular orIn multicellular organisms, how variation is achieved while cells comprise identical genetic information represents a fundamental open challenge my group strives to engage in the coming years. The development of a single fertilized egg into a complete embryo represents an especially beautiful embodiment of this problem. The process of differentiation is defined by the capacity of the cell ensemble to acquire increasingly more specialized internal states in a coordinated fashion. We are therefore excited by recent breakthroughs in single-cell transcriptomics and epigenomics since these can capture the emergence of embryonic cellular diversification at incredible resolution. But, we believe there is an urgent need in the field to match descriptive single cell atlases with models and experimental frameworks to derive novel understanding of function and regulation in this process.To this end, we will undertake three complementary approaches  all implemented during specification of the basic mammalian body plan (gastrulation) in vivo. (i) We will scrutinize parallel and converged differentiation in embryonic and extraembryonic lineages at absolute time. This will be achieved in both mouse and rabbit, providing unprecedented molecular insight into the evolutionary hourglass theory. (ii) Building on our recently developed capabilities, we will systematically dissect epigenetic mechanisms shaping and memorizing intracellular states. Importantly, we will do so by controlling for cell type and effects that propagate in and between tissues over time. (iii) Finally, we will chart and manipulate extracellular signaling affecting cell specification in the 3D embryonic space. Our study will provide mechanistic understanding and much-needed quantitative models that t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying Strategies to Manipulate the Immune System to Increase the Control of Tumors and Metastases' (ISMISICOTAM) under Seventh Framework.

assistant: **Objectives**

The number of cancer patients is increasing and effective treatments are still limited. The identification of tumor associated antigens (TAA) has allowed for the stimulation of the immune system to recognize and destroy solid tumors. The most common strategy is to increase tumor specific cytotoxic CD8 T cell responses by vaccination of the patient with dendritic cells (DCs) pulsed with TAA peptides. Despite a great deal of efforts, these therapies have not proven efficient at complete rejection of tumors and metastases.While CD8 T cells have been at the center stage of anti-tumor immunotherapies, the role of CD4 T cells in tumor immunity has remained largely underappreciated, although some reports have shown that CD4 T cells alone are able to protect against transplanted tumors in mice. Given the multiplicity of CD4 T cell functions, finding ways to enhance productive anti-tumor CD4 T cell response is of tremendous therapeutic interest. This proposal aims at identifying strategies to manipulate the immune system for increasing the control of tumors and metastases. Emphasis will be put on the interactions between CD4 T cells, DCs, and Natural Killer (NK) cells. The project will address the following questions:(1) Are solid tumors overall poorly immunogenic for CD4 T cells?(2) What cells are relevant at the tumor and draining lymph node sites for the TAA uptake and presentation?(3) Can one enhance anti-tumor CD4 T cell responses by manipulating NK cell functions? If so, is the increase of CD4 T cell responses beneficial for the control of both the tumors and metastasis?To answer these questions, I will use molecular biology, cellular immunology and in situ imaging of the anti-tumor response by microscopy. Overall, I expect the results to lead to major advancements within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integration centre for central Europe for research in energy supply from fossil fuels and renewable sources' (CENERG) targeting Fifth Framework.

assistant: **Abstract**

The European priorities in the energy sector and soon accession of the region to EU cause strong necessity to better integration of the activities in Central Europe in the area of research, production and distribution of energy from different sources. The project establishes Energy Integration Centre for Central Europe to improve links between similar institutes in the different countries in Central Europe as well as with energy research centres and power generation and distribution companies.The strategic objective of the Centre is improving the energy supply systems by increasing efficiency of energy production, while the pollutants emission should decrease. In particular the diversification of energy sources and integration of new RES with national energy systems actually based on fossil fuels is the most important.