RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemical Biology in Reactors and Cells' in the context of a Sixth Framework call.

assistant: **Objectives**

The programme of training seeks to provide an ideal environment for young scientists to gain experience in aspects of chemistry and the life sciences that relate to major problems facing Chemical Biology in the post-genomic era. With the completion of the human genome sequence our understanding of the molecular basis of disease and causative factors is set to increase enormously. Two major challenges for Chemical Biology in this post genomics era will be:- To meet the increasing demand for novel, relevant, biologically active compounds that can be used as drugs;- To deliver sensitive and quantitative extraction and detection methodologies for the high-throughput analysis of proteins and small molecules in research programmes aimed at determining the function of genes and the composition of the food we eat.The programme of research seeks to target two different classes of compounds important for health -therapeutics and health-promotors. It aims to develop a range of novel generic methodologies for the study of these two classes of compounds. Novel nanoscale separations materials will be produced, housed in capillary-borne microreactors linked with CCD imaging and mass spectrometry to permit real-time monitoring of the success of immobilised enzymes in therapeutic biotransformations. These same materials will be used to develop novel high-throughput separation methodologies for the analysis of different classes of health-promoting compounds extracted from plants. Together with genomic data, these analyses will enable a more complete elucidation of how the production of health-promoting compounds in plants is regulated. The programme depends on the multi-disciplinary input of analytical scientists, green chemists, plant biologists and biotechnologists and offers a unique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Secure Interactive Environments for SensiTive data Analytics' (SIESTA).

assistant: **Concept**

The FAIR principles provide a framework for enabling proper access and reusability of scientific data, and implementing them is a key goal of the European Open Science Cloud (EOSC). However, providing access to sensitive or confidential data while preserving privacy/confidentiality and usability for researchers is still an open question. Existing solutions like safe rooms, safe pods, or data safe havens are often challenging for the development of reproducible research and seem counter-intuitive when dealing with open science and FAIR principles. The SIESTA project aims to provide a set of tools, services, and methodologies for the effective sharing of sensitive data in the EOSC, following a cloud-based model and approach. SIESTA will provide user-friendly tools with the aim of fostering the uptake of sensitive data sharing and processing in the EOSC. The project will deliver trusted cloud-based environments for the management and sharing of sensitive data that are built in a reproducible way, together with a set of services and tools to ease the secure sharing of sensitive data in the EOSC through state-of-the-art anonymization techniques. The overall objective is to enhance the EOSC Exchange services by delivering a set of cloud-based trusted environments for the analysis of sensitive data in the EOSC demonstrating the feasibility of the FAIR principles over them.


**Keywords:** cloud computing, safe cloud, reproducible analysis, trusted environments, senstive data, data anonymization, epidemiology, energy, demographics, cybercrime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Psychobiological and nutritional influences on female reproductive health, well-being and cognition' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Psychological and nutritional factors in women's reproductive health, well being and cognition will be examined. A systematic review of the effects of nutrients on psychobiological markers will precede a study of nutritional and psychological features in infertility. Subsequent studies will examine the effects of dietary supplementation on key psychobiological markers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Computational Cloud Services and Workflows for Agile Engineering'.

assistant: **Innovation**

Traditionally, the European manufacturing industry is characterized by innovative technology, quality processes and robust products which have leveraged Europe's industrialization. However, globalization has exposed Europe's industry to new emerging and industrialized manufacturing markets and the current economic challenges have decelerated the internal boost and investment, respectively. Hence, new ICT infrastructures across Europe need to be established to re-enforce global competitiveness.The motivating idea behind CloudFlow is to open up the power of Cloud Computing for engineering WorkFlows (CloudFlow). The aim of CloudFlow is to enable engineers to access services on the Cloud spanning domains such as CAD, CAM, CAE (CFD), Systems and PLM, and combining them to integrated workflows leveraging HPC resources. Workflows are of key importance in today's product/production development processes were products show ever increasing complexity integrating geometry, mechanics, electronics and software aspects. Such complex products require multi-domain simulation, simulation-in-the-loop and synchronized workflows based on interoperability of data, services and workflows.CloudFlow is an SME-driven IP incorporating seven SMEs: Missler (CAD/CAM), JOTNE (PLM), Numeca (CAE/CFD), ITI (Systems), Arctur (HPC), Stellba Hydro (hydraulic machines/hydro turbines) and CARSA (business models and security). Four renowned research institutions comple¬ment the consortium: DFKI, SINTEF, University of Nottingham and Fraunhofer.CloudFlow will build on existing standards and components to facilitate an as-vendor-independent-as-possible Cloud engineering workflows platform. Open Cloud Computing Interface (OCCI), STEP (for CAD and CAE data) and WSDL (for service description and orchestration) are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Feasibility study for URBAN PROTECTION AVIATION COPTER S-100' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

SCHIEBEL will develop a new unmanned aerial system (UAS) for civil market applications including urban security which will be more cost-effective, reliable and versatile than current solutions. Currently air authorities worldwide are formulating the conditions to be able to operate UAS in the civil airspace, opening a myriad of new market opportunities. With its long-term experience and leadership in the UAS market and its cooperation with regulatory authorities, SCHIEBEL is expected to be the first company to operate in the category of professional UAS, a global market which is expected to reach a volume of 700 million USD in the next five years.SCHIEBEL’s UPAC S-100 will revolutionize disaster relief, protection and surveillance of critical infrastructure and other areas in urban environments, such as:- Supporting first responders in monitoring disaster areas (e.g., the fire brigade in locating a fire, where people are exiting or how to get around the problem area)- Instantly creating a temporary mobile phone network in only 30 minutes, dropping leaflets and talking to people via loudspeakers in case of destroyed infrastructure- Entering contaminated areas (too risky for manned assets) and identifying (through sensors) biological/chemical hazard leaks- Fast and flexible response to criminal acts (including terrorism) - Inspections/maintenance of critical infrastructures, e.g. power lines and pipelines- Improving coast guard activities, maritime emergency response and border controlThe Feasibility Assessment will define the regulatory requirements, the business case, the necessary technical developments and the changes needed within SCHIEBEL’s organization. It will define precisely the market potential in terms of geographical areas, type of clients, potential revenues
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '100% Renewable Energies for Energy Intensive Industries' (RE4Industry), addressing dissemination and exploitation.

assistant: **Impact**

The EU has started a progressive decarbonisation with the aim to become carbon neutral by 2050. Energy Intensive Industries (EII) are expected to play an important role in this transition as they represent 24% of the final energy consumption, but a clear long-term vision and strategy is required in order to remain competitive while contributing to the decarbonization targets of the EU. RE4Industry has been conceived under this framework with a twofold objective: to support EII in the identification and integration of renewable energy (RE) solutions together with the definition of Action Plans for decarbonisation, and to transform the EU industrial landscape into a large market niche for the uptake of RE while defining the appropriate framework conditions for short- and long-term scenarios.To this end, RE4Industry will set up and empower a comprehensive network of stakeholders and market actors who will identify feasible RE technologies and their market barriers and will interact with industry representatives to gather their needs, expectations, drivers and barriers towards the implementation of these technologies. Such an approach will be accomplished through a strong engagement strategy and the creation of RE4Industry Collaborative Network, who will receive from the project partners knowledge transfer material such as success cases, best practices, policy recommendations and technological roadmaps for promoting RE adoption.In parallel to the networking activities, RE4Industry will develop a baseline methodology for the design of Action Plans for decarbonisation in EIIs that will be developed and validated together with 3 representative industrial use cases from the steel, aluminium and chemical sectors. RE4Industry solid replication strategy will enable the roll out of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Methods leading to New Medications in Depression and Schizophrenia' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Despite dramatic advances in molecular and imaging technologies and nearly 1 5,000 articles on schizophrenia and depression (S&D) there are few novel treatments. We think this is because of three major “bottle-necks”: a lack of etiologically-driven or pathophysiologically-accurate animal models; a lack of tests that provide indication of efficacy in healthy volunteers; and the reliance of clinical trials on DSM categories which provide a collection of biologically heterogeneous patients. Our broad working hypothesis is that a focus on cross-species endophenotypes, testing in healthy volunteers and finding biologically-homogenous groups of patients will overcome existing limitations in target identification, early triage and clinical trials. To implement this idea six leading European institutions and two SMEs will partner with the EFPIA to: a) develop animal models that carry confirmed genetic risks, and in these animals to focus on cross-species endophenotypes (e.g., cognitive function, electrophysiology) to facilitate new drug discovery; b) validate the use of fMRI-based endopheno types in genetically-selected healthy volunteers and patients as early and surrogate markers for efficacy; and to combine this with PET approaches for plasma-kinetics to brain-dynamics modelling to provide guidance regarding optimal clinical trial design; and c) identify pharmacogenetic and multi-omic biomarkers that can be used to stratify patients within an umbrella DSM-diagnosis, thus allowing for ) targeted clinical trials, individualized treatment and back-translation of subgroup-specific biomarkers into preclinical drug discovery. To increase the chance of a breakthrough we will implement new analytical approaches (e.g. support vector machine learning algorithms; Bayesian analyses) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Europe-wide multi-modal on-trip traffic information' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

eMOTION aims to specify a Europe-wide multi-modal traffic information service that offers real time information for road and public transport users by means of on-trip-devices like PDA/Smart Phones or in-car-systems. The project develops policies and scenarios for a Europe-wide information service integrating content providers, service operators/providers with different legal status, coming from public and commercial sectors all over Europe. Policies and scenarios cover legal/organisational aspects as well as implementation and data safety policies, and meet in an organisational and legal framework for the service architecture and finally in a proof-of-the-concept.A system architecture with web-based application services calculates the information request of the user. The data content is organised in distributed databases providing the information on request. To enable distributed data management data sets will use common data protocols and interfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Telomeres: from the DNA end replication problem to the control of cell proliferation' in the context of a Seventh Framework call.

assistant: **Objectives**

Linear chromosomes of eukaryotes end with telomeres that ensure their stability. Because of the inability of semi-conservative DNA replication machinery to fully replicate DNA ends, telomeres require dedicated mechanisms to be duplicated and their length is eroded at each cell division. For this reason, telomeres constitute molecular clocks that determine cell proliferation potential in eukaryotes. Strikingly, we have shown recently that it is the shortest telomere in the cell that determines the onset of replicative senescence. This project aims a complete and detailed dissection of the in vivo DNA-end replication problem and the deep understanding of its impact for cell division capability. Specifically my goals are (1) the determination of the exact structures that result from the replication of DNA extremities, (2) the examination of the activities operating at the shortest telomere that triggers replicative senescence and (3) the investigation of the correspondence between telomere molecular structure and cell proliferation state at individual cell scale. To achieve this, I will undertake in Saccharomyces cerevisiae original and innovative single-molecule and single-cell approaches, that, in combination with genome-wide screens and sophisticated cellular settings, will allow to track and challenge a specified telomere of defined length. I anticipate that this work will lead to an in-depth understanding of how telomeres are replicated and how they enable the control of cell proliferation in eukaryotic cells, a matter at the intersection of the fundamentals of molecular genetics, cell biology of aging and oncology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'HIGHLY EFFICIENT CLADDING ECO-PANELS WITH IMPROVED NANO-INSULATION PROPERTIES'.

assistant: **Objectives**

The GELCLAD project aims at creating a novel cost-effective, durable, industrialised and easy to install composite insulation cladding system, based on a single multi-meso-structured panel with excellent insulation properties, made from functional bio-polymer composite (ecoWPC) as skin coupling with unique advanced foamable extrudable aerogel (FEA) as insulation core/layer. The GELCLAD is produced using a single co-extrusion procedure in which both ecoWPC framing skin and FEA core are simultaneously formed such that no discontinuity is formed between them. Using a multilayer effective continuous extrusion allows the benefits of high quality multi-meso-structured systems and productive production to be obtained without the traditional drawbacks of existing bonding lamination of extremely high embodied energy insulation materials, and high labouring and skilled installation of multi material layers. By combining also this biopolymer based ecoWPC/aerogel with passive pre-programed materials responding dynamically to ambient stimuli and control the air flow, GELCLAD wants to target the market as a novel environmentally friendly multi-functional smart cladding solution, to be used as an ecological alternative to the current cladding and ventilated façade systems. The foreseen impacts of the novel GELCLAD will be 20% lower embodied energy and carbon than traditional oil based panels, attain more than 40% reduction of energy savings due to GELCLAD refurbishment, reduce costs of 40% over traditional façade thanks to single panel systems, less installation and maintenance expenses, while providing functional building envelope solutions for a life span over 50 years. Full scale demonstration of the application of the novel cladding generation will be performed in demo and public
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photo/magnetic stimulated nanocargos for superior cancer treatments' (NANOCARGO).

assistant: **Innovation**

Breast cancer (BC) accounts for 28 % of the total cancer cases in the European Union (EU) and is the leading cause of cancer-related mortality of European women. The stratification of individual BC sub-types for corresponding therapy modalities is poor. Therapy outcomes in several BC sub-types are unsatisfactory. Its diagnosis is marred by high proportion of false positives and the economic burden to healthcare systems is very high. To overcome this NANOCARGO will develop a simultaneous diagnosis and therapy (theranostics) approach based on a multimodal nanocomposite termed as nanocargos. The battle against cancer is much more effectively fought if it is aided by early detection and, potentially concurrent, efficient treatment. NANOCARGO, introduces a new paradigm that theranostics can be made far more effective if a multimodal action can be integrated by adding a plasmonic shell to a magnetic nanoparticle core. The plasmonic shell can be functionalized with the chemotherapeutic drugs and aptamars. Magnetic@gold and magnetic@silver type core/shell nanocargos can be conjugated with anticancer aptamer. These nanocargos can be stimulated by simultaneous application of magnetic hyperthermia and photonic therapy. Cellular delivery can benefit from photoporation. Anticancer therapy can thus be made much more effective through the multimodal actions of these nanocargos exposed to endo-luminal, minimally invasive optical stimulation and extra-corporeal magnetic resonance imaging based excitation. Such a combined will maximise the delivery of these nanocargos into tumor cells. The magnetic core is advantageous for a controlled delivery of aptamer through an externally applied magnetic field. Gold and silver shell will support aptamer attachment. X-ray computed Tomography (CT) im