RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Signal Integration by Gene Regulatory Landscapes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Identification of the molecular mechanisms by which gene regulatory landscapes integrate diverse signaling inputs into a robust and dynamic transcriptional output is key to a comprehensive mechanistic understanding of the systems that govern vertebrate organogenesis. We will tackle this by taking advantage of our in-depth knowledge of the self-regulatory signaling systems controlling vertebrate limb development. To capture the dynamics by which the major signaling pathways (BMP, SHH, WNT, FGF) interact to control gene expression, we will profile chromatin architecture, epigenetic marks and the interaction kinetics of transcriptional effectors with cis-regulatory modules (CRMs) during mouse limb bud development. First, we will focus on the Grem1 gene regulatory landscape, as this BMP antagonist is a key node in the system and its spatio-temporal expression is regulated by all four pathways. This analysis will capture the temporal activity of all CRMs in the Grem1 landscape and reveal the ones that are targets of one or several signaling pathways. The functional requirements of single and multiple CRMs with redundant functions will be assessed by gain- and loss-of-function genetics in mice. This analysis together with in silico simulations of the relevant interactions aims to reveal the underlying regulatory logic. Second, the genome-wide datasets will be used to analyse the gene regulatory landscapes of signals involved in epithelial-mesenchymal and auto-regulatory feedbacks. Third, the trans-cis regulatory alterations underlying the evolutionary diversifications that resulted in digit loss and reductions will be functionally studied by comparative analysis of mouse, bovine, pig and chicken limb buds. Finally, as aberrant Grem1 expression predisposes to various diseases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SPACE ETHERNET PHYSICAL LAYER TRANSCEIVER', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The growing complexity of space systems is creating the need for high speed networking technologies to interconnect the different elements of a spacecraft. This interest has spurred initiatives by both ESA and NASA to define the next generation networking technologies for Space. In both cases, Ethernet has been the preferred choice due to its wide adoption in terrestrial applications and because it is fully specified in standards to ensure interoperability. The requirements for integrated circuits that have to operate in space are very different from those that are used in terrestrial applications. In particular, the radiation is much more intense and causes several types of effects on the devices that compromise their reliability. Therefore, special “rad-hard” design and manufacturing techniques are needed for devices that will operate in space. This means that to implement Ethernet in space systems, rad-hard Ethernet components have to be designed. The goal of this proposal is to design and manufacture rad-hard Ethernet PHYs (Physical layer transceivers). In particular a 10/100Mbps PHY is targeted as the first short term objective. This device will enable the use of Ethernet in space systems and also provide the starting point for the long term objective of implementing a Gigabit Ethernet PHY for space. To that end, the proposal includes a feasibility study and also contributions to the 1000BASE-T-1 Ethernet standard.To implement the Ethernet PHYs, the consortium has significant analogue (Arquimea) and digital (IHP) design capabilities. In addition, it has also experience on the upper layers of Ethernet and its use in Space systems (TTTech) and on the design and implementation of Ethernet PHYs and Ethernet standards (Universidad de Nebrija). Finally, the electronic te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Maintenance of epigenome integrity in response to DNA damage' (EpIn).

assistant: **Concept**

Protection of genome integrity is crucial for maintaining cell identity and viability. However, the organisation of DNA with histone proteins into chromatin in eukaryotic cell nuclei poses structural constraints to the detection and repair of DNA lesions. Dynamic and tightly controlled changes in chromatin organisation are thus critical for an efficient response to DNA damage, while at the same time preserving chromatin integrity. Yet, the underlying regulatory mechanisms are still poorly characterised, particularly in higher eukaryotes.Here, we describe a range of complementary approaches using cutting-edge imaging to address this issue in mammalian cells. Our aim is to investigate DNA damage-induced alterations at distinct levels of chromatin organisation, from histone proteins up to higher-order chromatin structure, and to explore the underlying mechanisms.(1) We first intend to provide a detailed analysis of histone variant dynamics at DNA damage sites by combining local induction of DNA lesions with pulse-chase imaging of histone proteins. (2) To examine how these dynamics are reflected at the level of higher-order chromatin folding, we will quantitatively visualise changes in chromatin compaction in cells exposed to genotoxic stress. For this, we will implement a recent FLIM-FRET-based approach and also exploit super-resolution fluorescence microscopy. (3) We will examine the spatio-temporal regulation of damaged chromatin reorganisation, analyse how it connects with DNA damage signalling and repair pathways, and characterise the histone chaperones and chromatin remodelling factors involved. (4) To broaden the range of candidate regulatory factors, we will screen for novel players in the DNA damage response among chromatin-associated proteins using laser micro-irr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multidimensional generAtion of bulk Photovoltaic currents by vectorial Light Engineering' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Replacement of fossil fuels with renewable energy sources is one of the main challenges of our time. Harvesting solar radiation is a possible solution, as the sunlight power reaching Earth is orders of magnitude larger than human consumption. However, the efficiency of photovoltaic solar cells is limited by dissipation of all the photons energy exceeding the semiconductor bandgap according to the Shockley-Queisser (SQ) limit. The bulk photovoltaic (BPV) effect arising in non-centrosymmetric crystals has attracted considerable attention as above-bandgap electrons are predicted to contribute to the photocurrent, thus breaking the SQ limit. To enhance BPV-device efficiencies the underlying tensorial light-matter interaction needs further attention. Until now, the contribution from the three-dimensional shape of the electromagnetic field has been neglected, while a greater emphasis has been placed on the effect of the in-plane field gradient. A comprehensive theoretical and experimental understanding of the vectorial coupling between the conductivity tensor and the three-dimensional field structure is thus far lacking. The goal of this proposal is to identify the mechanism governing this coupling through carefully engineered light beams and by nanoscale mapping of the photocurrent with a novel scanning probe technique. This knowledge will be used to develop an optimization algorithm to improve BPV-devices efficiency: given a target material it will return the light structuring which maximizes the photocurrent generation. During the project I will complement my skills in scanning probe techniques, optics and solid-state physics with methods in structured light and materials science/engineering. This unique set of skills will enable the progress of my career in the emerging f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Recent and Future Developments in International Tax Treaty Law' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The Department of Public Law and Tax Law of the Vienna University of Economics and Business Administration has already organised two very successful series of High Level Scientific Conferences within the 5th Framework Programme of the European Commission. Presently, there is a need to continue the process that has been started but could not be finished because of the large range of ideas and questions raised in the past, since the two subject areas are still of great importance for the development of tax law within the enlarged European Union.The ideal platform for achieving this goal is the organisation of a conference focusing on the dissemination of the scientific output of the past conferences. The event shall take place from 12 - 15 October 2006. Moreover, the project has a considerable networking dimension. At the conference, scientific experts from all over 'old' and 'new' Europe will come together and exchange their ideas. Also, potentials for future co-operations in Europe-wide research projects might be developed. Accordingly, the intended conference will make the research results of the preceding projects, which are of considerable value throughout Europe, accessible to as many people as possible.The planned event shall function as an international platform for the exchange of opinions and for providing tax experts with information that cannot easily be obtained, especially not on a Europe-wide level. Besides, the project is aimed at revealing future trends and developments in international tax law and tax treaty practice and at strengthening the integration of the European Union. The project will be coordinated by Prof. Josef Schuch, Chair of Public Law and Tax Law of the Vienna University of Economics and Business Administration. Following the conference, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'In Situ Analytical Tribology for Investigating Advanced Carbon-Based Materials'.

assistant: **Objectives**

The goal of the proposed project is to understand the physico-chemical basis underlying the excellent tribological properties of silicon oxide-doped diamond-like carbon (SiOx-DLC) coatings. SiOx-DLCs are amorphous films supposedly consisting of two interpenetrating, interbonded networks, one being a hydrogenated amorphous carbon network and the other a silica glass network. They exhibit impressive thermal stability and oxidation resistance and excellent tribological behaviour even at elevated temperatures, high contact stresses and in humid environments, making them promising candidates for several engineering applications.The goal of the project will be achieved via a hierarchical methodological approach aimed to determine the structure and composition of SiOx-DLC followed by the investigation of its thermal stability and tribological properties. The project has a strong multidisciplinary character and requires the novel combination of advanced analytical techniques. A new methodology, based on one of the most important surface-analytical developments emerging in the last decade - elevated-pressure X-ray photoelectron spectroscopy - will be used, enabling the study of the surface chemistry of SiOx-DLC at its critical environmental conditions (partial pressures of water, molecular oxygen, or hydrogen). Furthermore, the research project involves the extensive application, for the first time, of in situ tribological tests methods to the study of carbon-based materials for understanding the fundamental mechanisms underlying the environment effect on the tribological performance of SiOx-DLC.Establishing a fundamental understanding of the interrelationships between composition, structure, tribological performance, and durability for this class of carbon-based films can lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimisation of the metal cleaning process; evaluation of environmentally-adapted processes and recycling of washing' (1994-1998).

assistant: **Concept**

Cleaning and degreasing processes play an crucial role in determining the prosperties of a surface and thereby affect subsequent treatment or uses. The objective of the proposed project is to identify replacements for chlorinated solvents used in cleaning process and to optimise aqueous cleaning including recycling and waste water treatment. The project will also include develpment and formulation of chemicals and cleaning solutions that are environmentally acceptable and suitable for recycling. A very important issue that will be addressed is the use of closed loop systems so as to reduce consumption of water. This is especially significant for industry in southern Europe, where water is an expensive commodity. Direct industrial application of the research lies in metal cleaning process optimised with respect to quality assurance, increased productivity, waste minimisation, development of environmentally adapted chemicals, reuse of water and valuable raw materials, and a decreased cost for the cleaning. The project will increase knowledge about the entire cleaning process so as to achieve a stable and efficient process. The project includes the use of novel technologies with special focus given to techniques that can be used for cleaning of the surface, as well as changing its properties. The introduction of optimised metal cleaning process will benefit the competitiveness of the European industry with respect to improved production quality. Alternatives to the use of chlorinated solvents is also expected to be an important issue for the marketing of future European products. Collaboration between project partners will assure that an European network will be established, which will be advantageous for future work. The results from this project will be of particular int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Explorations in polar question meaning and its variation'.

assistant: **Concept**

This project addresses polar question meaning and its variation by documenting and analyzing nuanced polar question meanings and their expressions across languages. Under current models of polar question meaning, meaning nuances across languages are heavily undergenerated and certain effects such as negative polarity licensing and forms of bias remain elusive. We use the idea of the Duality of primary polar question meanings introduced in the applicant’s recent work as a departure point, which defends a separation between polar and other propositional alternatives. This view makes correct predictions in the treatment of existing problems and generates hypotheses as to the limits and structural correlates of variation. The project will generate a crosslinguistically viable semantic model of polar question meaning and a framework of its variation based on a sizeable empirical contribution detailing polar question usage profiles from a diverse set of languages, elicited with a state-of-the-art twin questionnaire. The project combines advanced insights and techniques from the semantics and pragmatics of questions, semantic variation, and linguistic documentation, and is particularly timely in the context of the applicant’s recent work. The applicant and the host possess crucial, complementary skills in addressing these issues. The applicant is an expert in syntax, intonation and linguistic variation. The entire host institute and in particular the supervisors are world-renowned for their work on semantics and pragmatics, with a strong focus on questions. Their collaboration will thus create a unique opportunity to thoroughly reanalyze a central topic from multiple theoretical and empirical angles while furnishing the applicant with skills in semantics, pragmatics and advanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation and impact of screening and treatment approaches for the prevention of cervical neoplasia in HIV-positive women in Burkina Faso and South Africa: HPV in Africa Research Partnership', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposal's overall aim is to improve cervical cancer prevention programs for HIV–infected women in Africa, by evaluating the effectiveness and cost-effectiveness of alternative screening strategies, and by developing algorithms leading to earlier detection and management of cervical cancer in these high-risk populations.The proposal's hypotheses are that: i) the use of simplified point of care diagnostic tests to detect high-risk (HR) HPV DNA , never before evaluated in Africa, alone or combination with other tests in various triage strategies has the potential to improve the coverage of cervical cancer screening in high-risk populations, and that it will prove a cost-effective cervical cancer prevention intervention in the long term; and ii) immune restoration and control of HIV replication through highly active antiretroviral therapy (HAART) or HAART initiation improves clearance of HPV infection among high-risk (HR)-HPV infected women, therefore slowing the development or progression of cervical precursor lesions. These findings may suggest that varying strategies or frequencies of screening may be required for women on HAART or not.The study will enroll 1200 HIV positive women (half on HAART or about to start HAART; and half with high CD4 count>350) in Burkina Faso and South Africa in a cross-sectional evaluation of cervical cancer screening strategies, from which about 1100 HIV-infected women without CIN2+ will be followed at one year to detect incident CIN2+ and persistence, incidence and clearance of HR HPV. A costing and modelling studies will determine the cost-effectiveness of triage strategies targeting HIV+ women.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'RElay based WIreless Network and standarD- REWIND'.

assistant: **Objectives**

REWIND focuses on one of the most important concepts in wireless network infrastructure that will revolutionize the level of wireless broadband services in terms of network capacity and coverage while reducing operational expenditures. This concept, the Relay based Wireless Network, will create through proliferation of low-cost, easy to install Relay Stations providing the necessary capacity and coverage to support new wireless applications with similar QoS currently available only through wired broadband service (e.g. DSL). At the same time the Relay Station receiving its capacity from its own access network through an efficient backhauling mechanism will maximize utilization of the infrastructure capacity and spectrum reuse, without the need for additional CAPEX or OPEX associated with dedicated backhaul. As REWIND is looking to develop state-of-the-art technology, products and network that will have effect on the network of the future in the coming years, it will be based on WiMAX, the most advanced, yet available and standardized broadband wireless technology. REWIND has two main objectives:Creation of a complete WiMAX relay based beta network including:-Network operator requirements and business case analysis-Network architecture and system specification-Development of relay technology and algorithms over a System on Chip (SoC) platform-Development of WiMAX relay beta prototype-System integration and interoperability of the developed relay product with standard WiMAX base station and subscriber station equipment-Lab and field performance testing of the integrated beta prototype relay systemTo provide support and directions to WiMAX relay standardization by providing inputs through participation and contributions on the aspects developed in the creation of the beta