RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'TRANSFER OF AN INNOVATIVE SENSOR TECHNOLOGY TO A COMBINED SENSOR AND FILTERING SYSTEM IN ORDER TO PROTECT FARMERS FROM PESTICIDES' (AGRASENS).

assistant: **Innovation**

For many years health statistics have shown that farmers using various types of pesticides have a lower life expectancy due to lung and stomach sicknesses. In agriculture and particularly in industrial agricultural, toxic substances (insecticides, weed-killers, fungicides, pesticides) are widely used. Furthermore accidents and poisoning often occur whilst handling toxic substances. These substances are normally only minimally poisonous to human beings, but constant handling by farmers can result in the long term accumulation in the body. The build up of toxins found in the farming sector can eventually lead to incapacity or even early death.In order to reduce the risk to farmers in intensive farming, the project proposed a new combined sensor-filtering system which is implemented in the tractor cabin. In case of spraying, watering or pumping pesticides, the cabin can be isolated from outside air. The sensor technology is already applied to the automobile sector and the filter system is in operation in the security sector. These functions are not provided by conventional air condition-systems and filters up to now but an integrated system built into a standard tractor cab could have important benefits. Thus, the combination of these existing technologies and their transfer to the farming sector should potentially lead to significant improvement in health protection for the farming industry.The project was a success both technically and also in terms of raising awareness and interest in the issue of minimising the exposure of farmers to toxic chemicals whilst driving a tractor. There is the potential for significant health and safety improvements to farmers using the technology. The composition of the consortium was also interesting in that in addition to technical expert
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Monitoring the effect of scrapie control policies that use genetics in different countries' (SCRAPIEFREESHEEP), addressing dissemination and exploitation.

assistant: **Impact**

In this project we want to determine the effect of introducing a genotype programme to reduce TSE incidence on the evolution of genotype frequencies, incidence of clinical disease, prevalence of infection and on relevant production traits, including fertility parameters as well as on other diseases and mortality rates. The results will be used to create mathematical and genetic models that can help to determine an optimal breeding strategy for scrape control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Quality of care and quality of life for people with intellectual and physical disabilities' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The proposed programme of research will investigate the quality of care for people with disabilities in regard to developments in social policy and typical examples of service practice, but will focus also on the subjective experience of individuals with d isabilities within these frameworks. The consortium will establish the range of options available for the care and support of people with physical and intellectual disabilities across the lifespan, within the context of European and other partner countri es. The project will investigate the extent to which these typical care and support options promote integrated living, social inclusion and service user participation; the role of attitudes to disability and persons with disabilities in relation to the delivery of care and service user's experience of social justice; and the impact of different service models and care practices on the quality of life of individuals with disabilities. Three cross cultural measures will be developed within the project and subsequently tested within both European and non-European participating centres: an index of the 'fit' between disability linked needs and available accommodation and care packages (the Accommodation and Care Fit Index - ACFI); a measure of attitudes to d isability and to persons with disability (the Attitudes to Disabilities Scale) with three related versions for direct use with individuals with intellectual and physical disabilities (ADS-D),indirect use with proxy carers (ADS-P), and direct use with mem bers of the general population (ADS-G); and a measure of the quality of life of disabled persons based on the existing World Health Organisation's quality of life measure, the WHOQOL, but adapted and extended for use with disabled persons and their carers (WHOQOL-DIS)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Satellite PArtnership for Computing Ephemerides' (ESPACE) targeting Seventh Framework.

assistant: **Abstract**

This ESPACE project aims at strengthening the collaboration and at developing new knowledge, new technology, and products for the scientific community in the domains of the development of ephemerides and reference systems for natural satellites and spacecraft by conjugating expertise of main European research centres involved in space sciences and dynamics, ROB, TUB, JIVE, TUD, CNES, DLR and IMCCE. The main part of the activity is focused on the extraction and analysis of astrometric data from space measurements not yet applied to the dynamics and to combine them with ground-based astrometric data. The project will also advance the European expertise in ultra-precise tracking of planetary probes and other deep space science missions. By these means, we intend to provide new dynamical models for several natural satellites, a characterization of their rotation properties, and improve spacecraft orbit determination methods for space science. The project is organised in 11 work-packages: coordination (management), radio science, laser ranging, VLBI (Very Long Baseline Interferometry), digitized data handling, astrometry, definition of coordination reference frames and improvement of planetary coordinate knowledge, methods for determination of spacecraft and satellites’ ephemerides, formation of databases, data access and distribution methods, educational and outreach activities. The project will concentrate at achieving maximum synergy between all the work packages above in order to deliver to the professional and at-large communities the best scientific products adequate to the present-day cutting-edge space science and technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Industrial Biological Biomaterials Doctorate'.

assistant: **Objectives**

The present proposal consists in an elite doctorate program designed to train PhD candidates at the highest academic level in combination with strong components in entrepreneurship, technology transfer and business development since part of the research and training will be carried out in an industrial environment and using a problem solving approach.The major scientific objective of this project is to grow stem cells of human origin in xenofree conditions. Currently, the clinical applications of human cells are limited partly because they are cultured using serum of bovine origin, thus with high risk of immunogenic reactions or zoonotic disease transmission. Human plasma-derived biomaterials, which are a priority of research and development of the industrial partner, are here proposed as an alternative supplement for cell culture. If successful, this proposal would profoundly impact on clinical transplantation of stem cells.The coordinating partner, INEB, is a relevant European research institute in biomedical engineering, specialized in the development of innovative biomaterials and cell therapies. The industrial partner is Grifols, a major healthcare company that produces life-saving protein therapies. The other partners involved are IBEC, a highly multidisciplinary research institute with well-established collaborations both with INEB and Grifols, and University of Porto and IPATIMUP, which will consistently contribute to the training program.The training program is designed to create PhDs with an entrepreneurial mindset. It involves a high quality multidisciplinary research environment, inter-institutional cooperation and international networking, and provides career development by adding the technological dimension through inclusion of a comprehensive range of tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional role of Foxp2 and Caspr2 in the cortex' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The identification of genomic variants associated with common neurodevelopmental syndromes is rapidly advancing. Recent estimates suggest that hundreds of genes are likely to contribute to susceptibility to a specific syndrome. Inherent in this hypothesis is the convergence of associated variants on common molecular networks mediating specific endophenotypes such as disturbed speech and language development across clinically distinct categories. Highly penetrant mutations account for only a fraction of language-related pathologies but are essential for understanding the common neurobiological underpinnings of these disorders.Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. Mice carrying an identical point mutation to that observed in affected patients have been generated (Foxp2+/R552H mice) but the functional significance of Foxp2 expression in cortical neurons in not known. We will characterize Foxp2-expressing cortical neurons and investigate the functional impact of the mutation at the cellular, synaptic and network level. Furthermore, FOXP2 binds to and dramatically down-regulates CNTNAP2, a gene that encodes the neurexin Caspr2 and was recently associated with several language disorders. Using CNTNAP2+/- mice we will assess the functional consequences of decreased Caspr2 expression in Foxp2-expressing neurons. We will also attempt to rescue the cellular phenotype observed in Foxp2+/R552H mice by reexpressing Foxp2 or downregulating its target genes in adult animals. Finally, Foxp2 is expressed in a fraction of neurons derived from human induced pluripotent stem cells (iPSC). Using iPSC-derived neurons as disease models is challenging since different neuronal subtypes are differentially sensitive to a mutation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'HER Imaging and Molecular Interaction Mapping in Breast Cancer'.

assistant: **Objectives**

The aim is to develop tools for imaging and characterising protein/protein and protein/RNA interactions in cancer using Designed Ankyrin Repeat Proteins (DARPins). DARPins are small, ultrahighly stable, antibody-like proteins that bind specific targets with high affinity in monovalent form and are readily engineered for site-specific chemical modification. The exemplar protein family will be EGFR, with focus on HER2-mediated processes in cancer.1. EGFR-reactive DARPins will be used to characterise HER2 homo- and hetero-dimers using 4 novel technologies: Single Molecule Fluorescence, Proximity Ligation, super-resolution microscopy and FRET/FLIM. The collected data will be analysed with information on clinical outcome to determine which HER2 interactions are associated with resistance to HER2 targeted treatments.2. Protein/RNA complexes will be isolated and characterised.  These complexes may be new biomarkers for breast cancer and their characterisation is aimed at elucidating mechanisms of transcriptional regulation in response to anti-HER2 treatment.3. Protein networks associated with EGFR signalling by imaging clusters of at 50-100 different proteins in a single cell or tissue section.  This will be achieved with a robot, using large dye-conjugated tag libraries, and automatically bleaching a dye after imaging and re-labelling with another.4. Whole body imaging (Phase I/II) clinical trial will use radiolabelled anti-HER2 DARPins to improve specificity and sensitivity of quantitative PET/SPECT/CT. The trial aims to image HER2 positive metastatic cancer and provide circulating tumour cells (CTCs) and biopsies for more detailed analysis.5. Multivariate data obtained by the new technologies will be analysed with a range of bioinformatic tools, including artificial neural
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel System for surface inspection and quality control for steel industries.' (EddyEyes) targeting Horizon 2020.

assistant: **Abstract**

European and global steel industry are facing several challenges, including meeting the high international quality standards. ISEND is a SME founded in 2006 and a acknowledged worldwide expert in industrial Non Destructive Test (NDT) systems that  is participated by the Venture Capital ”Sodical” to support its international growth. ISEND has identified a need from its customers (spread trough Europe, Asia, North&South America) in a specific niche market of the Hot rolling mill industries for metal wire rod to which the current commercial solution have strong weakness. In this market, the producers are required to fulfil quality standards for surface cracks lower than 1% of diameter. Claims from customers against the lack of these standards can reach 4% of total plant year production. Surface cracks inspection technologies, are difficult to implement due to plants harsh environment (1200 ºC and rolling speeds up to 120 m/s), massive production rates (>10 Mton/year). Those systems must also deal with different alloy grades, applications, and final product sizes (diameters covers from 5 to 90 mm, wire coil lengths range is from 14,000 m to 750 m).Our proposed system EddyEyes® is a surface quality control system for Non Destructive Testing of metal products in production plants  and is able able to detect, locate, display and storage surface cracks as smaller as  50 µm deep at 120 m/s rolling speed and 1200 ºC temperature in continuous operation. EddyEyes® selling price would be 0,4M€ (50% lower than our main competitors) what will allow the enduser payback period be less than 1 year.We have estimated that the worldwide market size for this product will be of 2.000 industries, from which we forecast that at least 20% will be interested in an improved quality control system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Worker 4.0 – Connected. Empowered. Safe and Healthy. The first intelligent and interoperable platform based on AI and wearable/IoT devices for real-time workers safety and health monitoring', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Artificial intelligence is a key priority for the European Union and is a field in which experts are in high demand. US tech giants are paying huge salaries for AI and machine learning talent, creating the potential for an EU brain-drain in the field. European AI research is well funded, but European ‘deep tech’ SMEs are generally less successful than the Americans at leveraging AI R&D into successful commercial ventures.  WearHealth is an intelligent decision support system that can use any 3rd party wearables and IoT devices. 3rd party hardware is integrated into our proprietary cognitive technologies to build an intelligent software platform that can identify markers of workers’ occupational risks, health, workload, and work efficiency. With these insights, businesses will be able to detect and predict worker safety and health risks, thus preventing accidents and managing their workforce to improve productivity and operational efficiency.WearHealth’s disruptive character is defined by its unparalleled performance, interoperability, and potential utility in a wide variety of market verticals, unlike any competitive commercial solutions. Following 10 years of R&D at the Artificial Intelligence Institute at the University of Bremen, our team has created a self-learning platform that improves as it analyzes new streams of data.EU industry leaders are already paying to use our version 1.0 platform for worker safety applications in transportation and energy.The goal of this project is to further segment target user groups and refine our go-to-market strategy for WearHealth version 2.0, guided by feedback from large-scale target user and client interviews and surveys.We project generating €40M annual revenue by year 3 after market launch, and directly creating 180 jobs over
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Single-molecule spectroscopy of coordinated motions in allosteric proteins', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Critical for the function of many proteins, allosteric communication involves transmission of the effect of binding at one site of a protein to another through conformational changes. Yet the structural and dynamic basis for allostery remains poorly understood. In particular, there is no method to follow coordinated large-scale motions of domains and subunits in proteins as they occur. Since the subunits of allosteric proteins often contain multiple domains, any such method entails probing the dynamics along several intra-protein distances simultaneously.This proposal aims at ameliorating this deficiency by creating the experimental framework for exploring time-dependent coordination of allosteric transitions of multiple units within proteins. Our methodology will rely on single-molecule FRET spectroscopy with multiple labels on the same protein and advanced analysis. We will explore fundamental issues in protein dynamics: relative motions of domains within subunits, propagation of conformational change between subunits, and synchronization of these motions by effector molecules.To investigate these issues, we have carefully selected three model systems, each representing an important scenario of allosteric regulation. While the homo-oligomeric protein-folder GroEL conserves symmetry in a concerted transition between major structural states, the symmetry of the homo-oligomeric disaggregating machine ClpB is broken via a sequential transition. Symmetry is attained only after binding to DNA and ligands in the third system, the family of RXR heterodimers. This exciting project will provide the very first catalogue of coordinated and time-ordered motions within and between subunits of allosteric proteins and the first measurement of the time scale of the conformational spre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'System to significantly increase the effective yield of Calcium (and other alloying elements) in the treatment of specialty steels, while reducing impurities in the melt'.

assistant: **Objectives**

Hotwire aims to develop a new, specially coated feed wire and dispensing system that is able to delay initial Ca core exposure from current duration of only 1.5 seconds to ~5 seconds, extend the Ca melt time (once exposed) from <1 second to ~3 seconds, through the application of thin, nano-particle enhanced heat resistant/intumescent coatings. To further increase the yield of the Calcium by enabling a wider dispersion area in the ladle by developing a novel, articulating feed head to allow wire feed across the entire ladle cross-section.