RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Complex Topology, Anyons, and Entanglement' (TOP-ANYON-ENT) under Seventh Framework.

assistant: **Objectives**

Topology and geometry are of fundamental importance in quantum physics. This proposal concerns applications of recent developments in topology and geometry to outstanding problems in condensed matter physics and quantum information theory. The first aim is to lay the foundations for the understanding of the influence of complex topology, which gives rise to generalized anyon statistics, on many-particle transport properties on networks, on entanglement of many-particle network states, and on topological quantum computing. The second aim is application of recent results on symplectic geometry and equivariant cohomology to the description and classification of quantum entanglement, the central concept in quantum information theory. The proposed research is multidisciplinary. On the mathematics side, it involves combinatorial graph theory, algebraic topology, cohomology of quotients and homogenous spaces. On the physics side, it concerns fundamental open problems in quantum many-body physics and quantum information theory. It is also very timely. The recent results on anyons on graphs may lead to new phenomena in quantum transport on networks, for example, generalizations of the integer and fractional quantum Hall effects. They can also provide new developments in topological quantum computing, especially in the topological quantum error correcting codes such as Kitaev's toric code. The distinguishing feature of the proposal is the unusual combination of methods, techniques and people involved. The research will be conducted in two world leading scientific institutions: Department of Physics, Massachusetts Institute of Technology and School of Mathematics of University of Bristol.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DNA methylation markers to predict treatment success of biologicals in Crohn’s disease.' under Horizon Europe.

assistant: **Concept**

Monoclonal antibodies have become a mainstay of therapy in common immune-mediated diseases (IMID) including Crohn’s disease (CD), rheumatoid arthritis (RA), and psoriasis (PsO). Current therapeutics include antibodies (“biologicals”) targeting inflammatory proteins such as Tumor Necrosis Factor (adalimumab), leukocyte trafficking (vedolizumab), or IL-12/IL-23 (ustekinumab). At present however, it cannot be predicted which biological will be effective in an individual patient, with only <40% of patients showing primary response to any given therapeutic. Treatment failure is associated with disease complications, and increased health care costs.. Hence the overwhelming need for predictive biomarkers to guide personalised medicine in IMID is evident. No biomarker to target therapy is validated in clinical practice.  In METHYLOMIC, we build on multiple previous cohort studies in which we confirmed epigenetic biomarkers (specifically DNA methylation) as the most stringent predictor of response to biological therapy, zooming in on CD. Specifically, we discovered and validated differential DNA methylation profiles in peripheral blood as biomarkers of response/deep remission for 3 approved biologicals in CD. Through the use of machine learning algorithms, treatment response could be predicted with up to 93% accuracy for each biological for CD, and RA. METHYLOMICS is committed to bringing personalised treatment-selection in CD and other IMID to clinical practice. We have teamed up clinical, epigenetic, and DNA diagnostics experts, patient organisations, and companies across Europe, for further validation studies, develop a marketable rapid targeted methylation assay that we than validate in a unique prospective randomised clinical trial for CD. Efficiency and cost-effectiveness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sovereign Wealth Funds, Internationalization and Political Connection' (SWF).

assistant: **Concept**

This proposal initiates research on the financial and corporate impact of Sovereign Wealth Fund investments in Europe and North America. SWFs are already large and active market players, thus of interest to regulators, economists and stakeholders of firms. Questions about their roles as investors need to be addressed and clarified. In this proposal, the researcher aims to study effects of SWFs as large, foreign, and politically connected shareholders. More specifically he asks: 1. Are SWF passive investors or activists shareholders that monitor and discipline managers? 2. What kind of companies do SWFs target as large shareholders? 3. What are the purposes of their transactions? 4. What is the market's reaction to SWF investments as large shareholders? 5. Do SWF affect firm value and how: internationalization and political connections? 6. How do SWF’s investments affect the welfare of other stakeholders (employees, creditors and bondholders)?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'XXth International Conference on Yeast Genetics and Molecular Biology' to be submitted under Fifth Framework.

assistant: **Abstract**

The International Community of Yeast Genetics and Molecular Biology which associates some 3 000 scientists from 21 countries all over the world holds regular international meetings at intervals of two years. The designated location of the XXth International Conference on Yeast Genetics and Molecular Biology is Prague, the capital of the Czech Republic. Leading experts will present 36 lectures in symposia and minisymposia covering recent advances in the field and bringing into focus novel themes for future investigations (see website www.biomed.cas.cz/yeast2001). Some 12 workshops on areas of broader interest and poster sessions covering 20 topics will enable participants to present their unpublished work. Modem yeast research is pursued by combination of classical and molecular genetics, molecular biology, biochemistry and bioinformatics.The complete sequencing of the firstgenome in eukaryotic organisms (Saccharomyces cerevisiae) achieved by the collaborative work of members of this yeast community, and the remarkable progress in sequencing the genomes of selected yeast species make these microorganisms uniquely tractable experimental systems attracting workers from other fields to address fundamental biological problems. Many of the new discoveries that will be discussed at the Conference have a great potential in research into cancer, aging, prion-based diseases and biotechnologies. The publicity of new discoveries and continued development of new biological techniques presented at the meeting will permit their use in medicine, bio-food and pharmaceutical industries. Owing to its central geographic position in Europe, the city of Prague offers an excellent opportunity to promote global exchange of ideas, personal contacts and fruitful international collaboration betwe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural studies of the RNA polymerase II transcription machinery: mechanism of start site selection' in the context of a Sixth Framework call.

assistant: **Objectives**

The current application concerns the mechanisms of transcription initiation in eukaryotic cells. The postdoc-project will be carried out in Prof. Roger D. Kornberg's laboratory at Stanford University, California.THE SPECIFIC AIM of the project is a molecular understanding of how RNA polymerase II (RNAP II) together with the general transcription factors (GTFs) can recognize promoter DNA and initiate RNA synthesis at a specific genomic location.Reports have shown that RNAP II and TFIIB are solely responsible for this process, but the underlying mechanism is still not known. Recently the structure of a RNAP II/TFIIB cocrystal has been solved in budding yeast. The transcription start site differs however in this yeast compared to fission yeast and most other eukaryotes including human so a general model for the selection process could not be elucidated from this structure.OUR MAIN OBJECTIVES are to do structural analysis of a RNAP II/TFIIB complex in fission yeast with X-ray crystallography and compare it to t he budding yeast structure. We will complement the structural information with mutational analysis of TFIIB in a pure in vitro transcription system derived from fission yeast developed by me as a Ph.D. student.THE OVERALL GOAL with the project is to generate a general molecular model for the transcription start site selection process.My stay will lead to the acquirement of new technological knowledge such as structural analysis of multi-protein complexes with X-ray crystallography that I believe will be a vibrant scientific field in the future.I will also be able to develop a scientific network that will be useful for my future career as a scientist, as well as the European community, after my return to Sweden.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Insulating materials for fire safety cables (PHOENIX)' (PHOENIX) under Fourth Framework.

assistant: **Objectives**

Objectives and content:In the field of electrical power distribution, fire behaviour of low voltage cables in public premises is a strong preoccupation, from both environmental and human safety concerns. Depending on the application, three classes of fire retardancy must be considered: flame retardant, fire retardant and fire safety cables. For this last category, not only the cables should not propagate the flame, or the fire, they must also continue to operate under fire conditions. This very strong requirement corresponds to an increasing world-wide vital market: public housing, hospitals, factories, large office buildings, off shore platforms, mass transit vehicles and marine vessels, etc. This market is highly competitive, within Europe, but also in Japan and in the US. Today, some products partly comply with standard requirements. However, present standards are considered non-realistic in most fire environments and are about to be modified: today, they involve testing at 750-900ÐC with mechanical shocks, and cables must keep operating during and after the tests. In future standards, testing will be performed at higher temperature (e.g. 1100ÐC), with mechanical shocks and under water spraying. There is no material/product available today which fulfils all these requirements. The objective is to develop new, low cost, halogen-free ignifugation processes, to guarantee cable operation up to 1100ÐC, for at least 90 minutes under water spraying. These properties will come in addition to standard non-toxicity, smoke emissivity and flame non-propagation requirements. Today, such cables include micaceous tape and/or 2 vulcanised silicone rubber layers.They provide current carrying capabilities during a limited time, for temperatures up to 900ÐC. These solutions are expensi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Anaerobic microbiology and molecular immunology of the digestive tract' (1998-2002).

assistant: **Innovation**

The European Commission has designated the Rowett Research Institute as a Marie Curie Training Site for Gut Microbiology and Immunology. Applications are invited from postgraduate students undertaking a Ph.D. on a related topic in a member state to spend 6-12 months at the world-renowned institute located in Aberdeen, Scotland. The student will join 180 research staff and 50 Ph.D. students at a pleasant location on the outskirts of Aberdeen. The training will cover a broad range of techniques relating to the biology of the gut and its microbial population, including- Anaerobic bacteriology by classical Hungate culture technique- Newer anaerobic chamber technologies- Rumen and human-intestine simulation fermenters- Molecular population analysis technology- Molecular phylogenetic analysis of anaerobic bacteria- Molecular phylogenetic analysis of ciliate protozoa- Transformation techniques for anaerobic gut bacteria- Assessment of immune status and barrier function of the gut epithelium in response to bacterial challenges- Chemical analysis of gut fermentation products In addition to these topics, formal instruction will be given in statistical analysis, information storage and retrieval, and the preparation of scientific material oral presentation and for publication. Applicants will also be expected to participate in one of the ongoing research programmes in gut microbiology and immunology, pursuing one of the above topics in greater depth. Equal opportunities are available for male and female students; female students are particularly encouraged to apply. Comfortable, secure accommodation is available on-campus. Students receive 1200 euros per month plus travel expenses. Further details of the Rowett Research Institute can be found at www.rri.sari.ac.uk. More details ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PLasmonics@Transparent cONductive oxidEs' in the context of a Horizon 2020 call.

assistant: **Objectives**

The capability of chemically and physically engineering the electrical and optical response of solids represents both the driving force and the consequence of the tremendous technological development of electronics, optoelectronics and plasmonics within the past century. As a most relevant example, the process—known as doping—of introducing foreign impurities in suitable hosts has led, among others, to the development of Transparent Conductive Oxides (TCOs), materials combining visible-light optical transparency with high electrical conductivity that are nowadays an irreplaceable component of solar cells and touch screens. Plasmonics and photonics, in parallel, have reached unprecedented levels of control of electromagnetic energy thanks to the possibility of fabricating and tailoring metallic nanostructures with physical dimensions down to the micro- and nano-scale for nano-antennas, perfect absorber and cloaking applications, to mention a few. One of the new challenges that researchers and engineers are facing is merging optical and electrical control in a single device for developing next-generation photovoltaic, opto-electronic devices and energy-efficient solid-state lighting.PLaTONE proposes the realization of a novel class of materials combining plasmonic resonators with TCO-based thin-film capacitors, a system envisaged in literature but not yet achieved. PLaTONE will address the fabrication and the electrical/optical characterization of these systems and exploit the mutual interaction between the plasmonic nanostructures and the voltage-controlled dielectric properties of the TCO for achieving an active optoelectronic device. PLaTONE musters up a team of highly experienced researchers from both academic and non-academic institutions to tackle the issue, and pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Wall insulation novel nanomaterials efficient systems' (Wall-ACE).

assistant: **Concept**

Wall-ACE will develop a consistent package of new advanced sustainable insulation products and systems. The HONEST (High performance Optimized Nanomaterial Energy efficient SysTem) package is a “modular toolbox system” providing a set of complementary solutions that will address most of the complex challenges raised by thermal renovation as well as new construction.The HONEST package includes: insulating thermal coating-finishing with low emissivity, internal high performance insulating plaster, insulating interior patching filler, external high performance insulating render, and insulation clay bricks. These products/systems will provide top insulation performance as well as improved comfort, indoor air quality, fire safety, durability and sustainability. These highly efficient products are achieved through the synergy between the different members of the consortium through combining the high performance, sustainable, and advanced nanotechnology of the silica aerogel, with existing, already approved, efficient products. The aerogel materials structure properties and cost will be optimised. The process of the five high efficient mineral insulation systems will be scaled-up to test replicability, processability and reach industrial scale. Then, these five systems will be fully characterised including an LCA assessment, along with certification and standardization activities.In addition, the project sets a major focus on the “go to market” validation of the five products. Business planning and a field market test will be carried out, along with performance assessments on real buildings, and training and communication tools design, in order to maximize use potentials and foster a wide replication throughout EuropeThe products from the Wall-ACE project are key enablers to e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The importance of submarine groundwater discharge for the southwestern Baltic Sea' (SGDBALTIC).

assistant: **Concept**

Submarine groundwater discharge (SGD), i.e. the subsurface flow of water to the sea, is now considered as an important pathway for dissolved matter transfer from the continent to the sea. Although several studies indicate that a considerable part of unmonitored waters enter the Baltic Sea, the importance of SGD is poorly studied. We propose to survey the southwestern Baltic Sea for SGD and to measure the associated fluxes of nutrients, selected major and trace elements. These studies should allow an assessment on the importance of SGD for eutrophication and thus for the coastal ecosystem in the area investigated. In order to better understand the chemical reactions determining the chemical composition of SGD we will investigate the subsurface mixing zone between freshwater and groundwater (subterranean estuary). This research will enhance our knowledge on continent-ocean connections and the expected results will be important for other coastal regions in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Disability benefits, labour force participation, and health: Evaluating the effect of social protection policies' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the last decade, financial crises and population ageing have led to the retrenchment of the welfare state. One area under financial pressure is the provision of disability benefits. In response, governments have reduced expenditures by tightening eligibility criteria or reducing the benefit amounts. The Netherlands has become an example of such a system as it has persistently reduced the number of new individuals receiving disability benefits. Even though the reforms seem to have achieved their objective, there is little understanding of how they impact labour force participation and individual level health. The literature shows that not receiving a disability benefit leads to higher probabilities of working. However, there is surprisingly little about whether the effect is persistent, whether it differs across education groups, and whether it impacts household members. By contrast, there is a dearth of knowledge on the causal effect on health. This is especially striking since the original aim is to protect health. This research will contribute to our understanding of disability benefits by estimating their causal effect on work and health. For that, I will use unique administrative data from the Netherlands and exploit the regulations that define eligibility by means of an innovative empirical approach. The combination of this approach and the Dutch data will allow me to estimate the effect of disability benefits on work and health, and more importantly, to evaluate its persistence, its heterogeneity by education, and its impact on household members. As many countries strive for the financial sustainability of social programs, the knowledge generated in this research will provide valuable evidence of how government benefits impact labour force participation and ind