RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Conceptualizing the effect assessment of toxicant mixtures to soil organisms' (1994-1998).

assistant: **Innovation**

The protection of soil ecosystems against toxic compounds is one of the main objectives in the environmental policy of the European Union. This policy has led to the successful development of soil toxicity tests for a range of soil organisms funded by the EU. So far these tests have been used to determine the effect of single compounds separately. In the field, however, soil organisms are exposed to a mixture of different toxicants at the same time. In contrast to aquatic toxicology, the ecotoxicological effects of mixtures in soil are poorly understood and data are very scarce. Within the soil, complex interactions with the soil matrix occur due to sorption, transformation and speciation dynamics thus influencing bioavailability of mixtures. Moreover comprehensive concepts for mixture toxicity in soil are lacking which may hamper a refined and more realistic implementation of regulatory guidelines for safeguarding soil ecosystems. The objective of this proposal is to assess the sublethal effect of toxicant mixtures on soil organisms and to look for general concepts which are applicable for different groups of compounds in soil. Recently developed sublethal soil toxicity tests using organisms with different uptake routes will be used in an integrative approach. Concepts on mixture toxicity (toxic units, funnel hypothesis and isobolographs), founded by aquatic toxicologists and pharmacologists will be used as a basis for their suitability in soil ecotoxicologal effect assessment procedures. The participants are linked together by: i) testing the same predefined mixtures (mixture 1, compounds with non-specific mode of action : copper, cadmium, lead and zinc; mixture 2, compounds with specific mode of action: carbendazim, iprodione and copper) with different invertebrate s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Highly Functional Polypeptides'.

assistant: **Objectives**

Peptides are nature’s expression language and as such perform vital roles in living organisms. They are highly functional and produced naturally with a precision that is unprecedented in synthetic materials such as polymers. Synthetic polypeptides present a promising alternative as they combine the accessibility of synthetic polymers with functionality and biocompatibility of natural peptides. They are thus ideally suited as a new (commercial) renewable and sustainable polymer materials platform if some practical hurdles can be overcome.In this project, new routes for the synthesis of polypeptides will be explored that are inexpensive, scalable and reproducible and allow the tuning of polypeptide properties by copolymerisation. While the approach to be taken is generic, our efforts will focus on the synthesis of Glatiramer. Glatiramer is a commercial product that is currently synthesised by ring opening polymerisation in an uncontrolled fashion, yielding a random copolymer of four amino acids. By improving our understanding of the reaction kinetics, we are aiming to gain a better control over the polymerisation and prepare well-defined Glatiramer-like polypeptides. Subsequently a combinatorial library will be prepared and the various Glatiramer-like polypeptides will be screened for biologically activity towards multiple sclerosis.This is a highly interdisciplinary project at the interface of polymer chemistry, combinatorial chemistry and life science. The applicant’s diverse experience makes him an ideal match for this work. The project also brings together academics from world class institutions with complementary expertise that provides a unique environment for the applicant to develop his skills and accelerate his academic career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE ENDOCYTIC AND CYTOSKELETAL MATRIX IN THE PLASTICITY OF TUMOR CELL INVASION AND MIGRATION' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Tumor cells can adopt different modes of cell motility. The ability to switch between diverse modes of migration enables tumors to adapt to micro-environmental conditions and to metastasize. The critical pathways and cellular processes underlying the plasticity of tumor cell motility have only begun to be identified.Endocytosis, originally thought of as a device to internalize nutrients and membrane-bound molecules, is emerging as a connectivity infrastructure (which we call ""the Endocytic Matrix"") of different cellular networks necessary for the execution of various cellular programs. A primary role of the Endocytic Matrix is the delivery of space- and time-resolved signals to the cell, and it is thus essential for the execution of polarized functions during cell migration. The molecular mechanisms it uses are, however, ill defined and likely to involve, in addition to extranuclear pathways, also transcriptional programs. In this respect, we have acquired evidence that components of the Endocytic Matrix require de novo gene expression to promote the transition in the mode of tumor cell motility.We propose to identify critical components of the Endocytic Matrix that by controlling the cellular location of actin remodellers promote the plasticity of tumor cell migration. We will also test whether, in addition to the immediate epigenetic/signalling-based control of migration, the Endocytic Matrix regulates transcriptional programs required for the acquisition or maintenance of diverse modes of motility. Finally, in view of the key role of microRNAs (miRNAs) in cancer, we will use miRNA profiling, together with endocytic cell migration and invasion assays in human cancer cells to test whether miRNAs mediate the relationship between endocytosis and motility programs.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stardust Reloaded' in the context of a Horizon 2020 call.

assistant: **Objectives**

The current amount of space debris in orbit combined with the expected increase in traffic due to future mega-constallations will have an unprecedented impact on the space environment, posing a serious question on its stability and resilience to any incident or anomalous event. Although statistically less likely to occur, an asteroid impact would have devastating consequences for our planet. Thus Stardust-R will address the growing need for a sustainable exploitation of space, the resilience of the space environment, the threat and opportunities coming from asteroids and comets and the compelling need for properly trained specialists who can tackle these issues.The key scientific objectives are: 1) to globally characterise the dynamics of objects around the Earth to define disposal solutions, 2) to correlate spatially and temporally distant events and families of debris to their parent object, 3) to quantify uncertainty in celestial mechanics to accurately predict the probability of impact and collision and quantify the resilience of space systems and environment, 4) to develop AI tools and methods for space traffic management, 5) to define a criticality index for small asteroids to identify the need for exploration/characterisation, the possibility for exploitation and the method of deflection, 6) to develop a new distribution model for small size asteroids, 7) to develop systems and algorithms to explore and land on minor bodies with autonomous nano-spacecraft.These objectives will be achieved via 15 projects developed by 15 Early Stage Researchers who will be trained in math phyisics, computer science and aerospace engineering to provide effective solutions to make the space environment resilient, space exploitation sustainable, learn more about minor bodies and ulti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dynamic Urban Environmental Exposures on Depression and Suicide'.

assistant: **Concept**

19% of the Dutch population suffer from depression and people affected by depression have a significantly higher suicide risk. Although the World Health Organization attributes modifiable environmental factors including urban environments (i.e. the built, natural and social environments) to health outcomes, they are largely disregarded as either stressors or buffers in scientific debates on depression and suicide. A limitation of current studies is that urban environmental features are often restricted to the neighbourhoods within which people live. This may result in incorrect conclusions about health-influencing factors and inappropriate policies. Human life ultimately unfolds over space-time; people are exposed to multiple urban environments not only during daily life but also over the course of their lives. It is this, not yet assessed spatiotemporal interplay of urban exposures that might revolutionize health assessments.This research aims to understand the interactions between urban environments, depression and suicide in the Netherlands. The scientific breakthrough will be dynamic health geographies embedded in space-time by two innovative case studies. We will investigate the following research questions: What are the associations between depression and the built, natural and social urban environments along people’s daily space-time paths? And what are the associations between suicide and the built, natural and social urban environments of previous residential locations?A multidisciplinary approach combining health, geographic information science and urban geography will lead to this breakthrough. It will be grounded on cutting-edge smartphone-based human tracking, health register data and spatiotemporal modelling. Knowledge about dynamic urban exposures is key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low latency and high throughput dynamic network\ninfrastructures for high performance datacentre interconnects' (LIGHTNESS).

assistant: **Innovation**

The main objective of the LIGHTNESS project is the design, implementation and experimental evaluation of high performance data centre interconnects through the introduction of innovative photonic switching and transmission inside data centres. Harnessing the power of optics will enable data centres to effectively cope with the unprecedented demand growth to be faced in the near future, which will be driven by the increasing popularity of computing and storage server-side applications in the society. Indeed, the deployment of optical transmission systems leveraging Dense Wavelength Division Multiplexing (DWDM) allows the transmission of more than a hundred of wavelength channels operating at 10, 40, 100 Gb/s and beyond. This effectively results in unlimited" bandwidth capacities of multiple Terabit/s per fibre link, which can be efficiently utilized through next-generation all-optical switching paradigms like Optical Circuit Switching (OCS) or Optical Packet Switching (OPS).In this context, the LIGHTNESS project will join efforts towards the demonstration of a high-performance all-optical hybrid data plane for data centre networks, combining both OCS and OPS equipment to implement transport services tailored to the specific applications' throughput and latency requirements. To this goal, an OPS node suitable for intra- data centre connectivity services will be developed and prototyped during the project, together with an enhanced Top of the Rack (TOR) switch seamlessly connecting servers in each rack to the hybrid OCS/OPS inter-cluster network. As an additional achievement of LIGHTNESS, the OCS/OPS inter-cluster network will be empowered with a control plane entity able to dynamically provision both OCS and OPS transport services in response of either the data centre man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ELectric Field control Over Spin molecules' (ELFOS).

assistant: **Concept**

Information technology is partly based on magnetism (memory) and partly on electricity (processors). Increasing control over individual electron charges and spins provides new device functionality. For both charges and spins, molecular devices provide ideal test beds, which have witnessed increased interest over the last decade but the understanding and control of which is still in an infant state. The aim of ELFOS is to take single-molecule electronics to the next level in which single molecule device functionality will be exploited. We will combine different experimental test beds to gain knowledge about molecular functionality with an emphasis on the spin degrees of freedom and how to exploit these in device configurations using electric fields. In information processing, spins have the general advantage over charges in that they are less sensitive to the coupling between the molecule and its environment and hence to the molecular orientation which is difficult to control at the atomic level. Furthermore, the control of molecular spins by electric fields is preferable over magnetic-field or light-driven control since it allows for the application of strong fields at a local scale and for the fast manipulation of spin states. Guided by theoretical studies of radically new concepts, we will manipulate the molecular spin either by controlling the charge states of the molecule by the gate or by the gate directly. The molecules of interest are single-molecule magnets, spin triangles, spin chains and spin-crossover compounds. The experiments should provide an answer to key questions such as: Can individual magnetic molecules be addressed electrically as bits or qubits?" and "How can they be used as switches?" Applied aspects are long term with high risk and high potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural and functional organization of the secretory pathway' (1998-2002).

assistant: **Concept**

This network's main goal is the elucidation of the structural and functional organization of secretory organelles in living cells. Our present understanding of the morpho-functional organization of the secretory pathway is limited and, in spite of much debate and speculation, even the general organisational principles of secretory transport are still unknown. Indeed, the classic exclusively vesicular traffic scheme is no longer tenable, and there is evidence that tubular intermediates contribute to transport. At the centre of the secretory pathway lies the Golgi complex. Transport to and from the Golgi occurs by virtue of membrane-bound structures or transport intermediates (TIs), in which cargo proteins are included during transit between successive membrane compartments. To understand how the Golgi complex works, it is indispensable to determine the nature of the Golgi-related TIs, in terms of fine structure, dynamics in vivo, and molecular organization. This network will systematically analyse how membrane traffic moves into, through and out of the Golgi complex using a new repertoire of technologies and concepts. The proposal is structured on the following two aims:A) To study the physiology of the secretory pathway: membrane trafficking dynamics in vivo and ultra structure of Golgi-derived transport intermediates (TIs).B) To unravel the molecular mechanisms underlying the function of TIs as defined in (A): the role of proteins and lipids in TI formation: fission, fusion and sorting membrane events.Such tasks require an interdisciplinary strategy, including advanced morphological, molecular and cell biological approaches, and the knowledge of each of the transport stages in Golgi-related traffic. The teams recruited in the network are well equipped to provide the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aquaculture and its role in integrated coastal zone management. A European and international workshop' to be submitted under Fifth Framework.

assistant: **Abstract**

The main objective of this workshop is to provide and disseminate improved information on aquaculture and its relationship with other coastal resource users to help producers, stakeholders, policy makers, planners, researchers and managers in developing best ICZM practice for the aquaculture industry, through a trans-disciplinary approach. To aid the debate the past, current and future status of coastal aquaculture will be discussed.A second objective is to develop stronger interdisciplinary communication between the natural and social sciences and to improve the utility of available scientific information and knowledge to all players. one approach will be to promote aquaculture as a sustainable food production industry.A third objective is to promote new perspectives on sustainable uses of coastal areas and their natural resources by means of improving collaborative coastal aquaculture research and improved production of existing and new species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plasmonic-based autOmated lab-on-chip SEnsor for the rapid In-situ Detection of LegiONella' (POSEIDON) under Horizon 2020.

assistant: **Objectives**

Legionnaires’ disease is a serious form of pneumonia caused by bacterium Legionella pneumophila, with a case-fatality ratio on the order of 10-15%. L. pneumophila proliferates in aquatic habitats, especially in potable water, air conditioning, hot and cold water systems, cooling towers, evaporative condensers, spa/natural pools. Actually, its detection and monitoring rely on time-consuming protocols (in the order of several days) based on in-vitro selective bacteria culture methods, performed by highly specialized personnel in dedicated laboratories. POSEIDON project targets to change the approach in bacteriological environmental monitoring and in infection risk management by developing a fully automatic and reliable system. Handling of the air/water sample will be designed and integrated in preconditioning system and microfluidic device through which whole bacteria cells will be transported from the sampling module to the sensing plasmonic surface. The complete measure protocol will be integrated and performed according to EU legislation guidelines. Specificity will be ensured by immuno-functionalization of gratings surfaces and enhanced system sensitivity will be granted by the optimization of the optical detection system architecture. Sensors based on Grating Coupled Surface Plasmon Resonance (GC-SPR) in azimuthally rotating configuration have recently proved sensitivity enhancement up to almost two orders of magnitude. Furthermore, the symmetry breaking related to grating rotation allows exploiting the incident polarization, more easily controlled with respect to incidence wavelength and angles interrogation. The prototype will be designed to be integrated in water distribution or HVAC systems in order to demonstrate its feasibility in industrially relevant fields a