RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding the role of lysosomes in the intercellular TNT-mediated spreading of α-synuclein and the impact of lysosomal dysfunction' under Horizon 2020.

assistant: **Concept**

Over the last few decades, neurodegenerative diseases (NDs) became one of the top 10 global causes of death. The accumulation of misfolded protein aggregates in affected brain regions is a common hallmark shared by several NDs. Misfolded alpha-synuclein (α-syn) accumulates in Parkinson’s disease (PD), the second most common ND, and recently a “prion-like” mechanism linked to the spreading of α-syn has been suggested for the pathology progression. The Zurzolo group demonstrated that α-syn fibrils spread between neuronal cells inside lysosomes through tunneling nanotubes (TNTs), thin actin-based membrane protrusions mediating intercellular transport of various cargos. As known, lysosomes move along microtubules therefore this research aims to understand how lysosomes can move inside and through actin-based TNTs. The host lab also showed that the transferred α-syn fibrils induce the aggregation of soluble cytosolic α-syn in receiving cells and this project will unravel the mechanism by which α-syn fibrils escape from lysosomes to induce the aggregation of monomers in acceptor cells. In addition, since lysosomal dysfunction is a common feature of NDs, this research will shed light on the functionality and fate of α-syn-loaded lysosomes. Lysosomal dysfunction is also a trait of Lysosomal Storage Diseases (LSDs), a group of about 50 rare inherited metabolic disorders generally caused by the defective function of a specific lysosomal enzyme leading to the lysosomal accumulation of non-degraded materials and neurodegeneration in the forms most severe. This project will investigate the correlation between LSDs and NDs and the possible implications of TNTs in LSDs that represent a new perspective for LSDs etiopathogenesis. By combining my skills in lysosome physiopathology and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chromatin Packing and Architectural Proteins in Plants' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The three-dimensional organization of the genome, which strikingly correlates with gene activity, is critical for many cellular processes. The evolution of molecular techniques has allowed us to unveil chromatin structure at an unprecedented resolution. The most intriguing chromatin structures observed in animals are TADs (Topologically Associating Domains), which represent the functional and structural chromatin domains demarcating the genome. Structural proteins such as insulators proteins, on the other hand, have been shown to play crucial roles in mediating the formation of TADs. However, major structural factors relevant to chromatin structure are still waiting to be discovered in land plants. My preliminary work shows that TADs are widely distributed across the rice genome, and motif sequence analysis suggests the enrichment of plant-specific transcription factors at TAD boundaries, which jointly give rise to an exciting hypothesis that these proteins might be the long-sought-after insulators in land plants. By using various state-of-the-art molecular and computational tools, this timely project aims to fill a huge gap in plant functional genomics and substantially advance our understanding of three-dimensional chromatin structure. This project consists four major aims, which collectively will uncover the identities of plant insulator proteins and generate insights into the dynamics of structural chromatin domains during stress adaptation. Aim 1 will identify and characterize the stability and plasticity of functional chromatin domains in the rice genome during temperature stress adaptation. Aim 2 will identify insulator elements and other structural features of chromatin packing in the Marchantia polymorpha genome from a structural genomics approach. Aim 3 will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unified Theory of Efficient Optimization and Estimation' (UTOPEST), addressing dissemination and exploitation.

assistant: **Impact**

The goal of this project is to make progress toward a unified theory of efficientoptimization and estimation. In many computing applications, especially machine learning,optimization and estimation problems play an increasingly important role. For that reason, a largeresearch effort is devoted to developing and understanding the limitations of efficient algorithmsfor these problems. For many of these problems, achieving the best known provable guaranteesrequired the use of algorithms that are tailored to problem specifics. In recent years, the PI’sresearch with collaborators has shown that for many optimization problems, the conceptuallysimple sum-of-squares meta-algorithm, despite not being tailored to problem specifics, can matchand often significantly outperform previous efficient algorithms in terms of provable guarantees.This project aims to better understand the capabilities and limitations of this meta-algorithm,especially for estimation problems, which have only recently begun to be studied in this light.In this way, the project will establish new algorithmic guarantees for basic optimization andestimation problems even in the face of non-convexity and adversarial outliers. In the same way,the project will shed light on the limitations of efficient algorithms for basic average-case problemslike planted clique and stochastic block models.The project also aims to transfer the obtained theoretical insights into practical algorithmsbuilding on recent works by the PI and collaborators. Toward this goal the project will developnew algorithms with close to linear running times that match the guarantees of the best knownpolynomial-time algorithms. In order to assess their practicality, the project will perform systematicempirical evaluations of these algorithms.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Induction Heating and Health Monitoring Solutions for Smart Aircraft Maintenance using Adapted Composite Patches'.

assistant: **Concept**

The aim of INDUCER is to provide the possibility to make high integrity adhesive repairs using a unique single multi-functional magnetic sensor for “Smart Curing” the bond and to monitor the structural integrity of the repair in service. INDUCER will produce a complete operational chain of equipment, software and sensors that will revolutionise the technology of composite repair bonding by combining heating, stress localization, stress compensation, structural health monitoring, lightning protection and earthing. In this project, the R&D of the advanced new generation bonding equipment with multi-functional magnetic sensors for real time “smart curing”, relief of stresses and integrity monitoring of repaired structures will be performed. The participating partners have a range of complementary expertise, resources, and test facilities, which, when combined, meet the needs for the completion of a successful project. Bonded composite repaired areas of aircraft structures frequently suffer from a variety of factors that may influence their structural integrity, on either a short or long term basis. In order to overcome these drawbacks, an innovative “sensorized” composite repair set-up is proposed, combining three different technical achievements through the embedding of a magnetostrictive sensor mesh (i.e. metallic mesh composed of small diameter sensors measuring changes in magnetic property with stress according to magneto-elastic phenomena) in the repair area. The use of this magnetostrictive sensor mesh will simultaneously achieve the following effects: a. “Smart” curing of the repair by induction heating. This will replace conventional conduction heating, using resistance powered heating blankets. b. Health monitoring of the repair by interrogating the magnetostricti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Involvement of the endoplasmic reticulum stress response in lung dendritic cell function and inflammatory lung diseases' (2007-2013).

assistant: **Innovation**

Dendritic cells (DCs) are essential for the instruction of adaptive immunity and for the pathogenesis of many inflammatory lung diseases. These cells sense the presence of exogenous and endogenous signals and initiate an immune response that is matched to the nature of the offending insult. Many environmental triggers of inflammatory lung diseases including allergens, cigarette smoke, fine dust particles or microbes induce signs of endoplasmic reticulum (ER) stress in lung cells. ER stress is characterized by an accumulation of unfolded proteins in the ER, which leads to an intracellular signalling cascade named unfolded protein response (UPR). Although it has been recently shown that the UPR is a constitutively active signalling pathway in DCs, it is unknown whether activation of the ER stress pathways in DCs contributes to the regulation of immune responses at mucosal sites.The foundations of this project lie in three crucial aspects of DCs: 1) DCs are important sensors of exogenous and endogenous danger signals in the lung, 2) DCs are active targets of the ER stress response, and 3) DCs are central coordinators of the immune response that leads to asthma. Based on these three aspects, we hypothesize that the presence of unfolded proteins in the ER acts as an endogenous danger signal that plays a fundamental role in the function of lung DCs and their involvement in inflammatory lung diseases.With this project, we will gain firm knowledge about the cellular events that coordinate the ER stress response to environmental triggers in DCs. By using innovative approaches, we will analyze the relevance of the UPR signalling in lung DC subsets in vivo. In addition, in light of previous findings reporting the genetic association between polymorphisms in the ER stress regulator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Visual recognition and mechanical handling of flexible materials' (VENFLEX) targeting Fourth Framework.

assistant: **Abstract**

The focus of this project is on automated production and manufacturing processes that require on-line assessment and sorting. European SMEs working in the field of manufacturing are often characterized by a low technological level. Moreover, repetitive and unskilled tasks are still demanding to operators. A clear disadvantage with respect to non-European industries, who have much lower production costs (e.g.,man power), must be pointed out. This proposal concerns the study and development of innovative techniques for automating and optimizing industrial processes. The system comprises two main components which will communicate directly to achieve automated sorting of disordered work-pieces such as fur skins, fabric or other flexible components. First a machine vision system comprising a computer controlled lighting and digital camera and associated image processing boards and software will be used to recognize specific work-piece objects. The location and orientation of individual work- pieces will be determined. The second system component, a manipulator arm will be to pick up the work-piece, re-orient it and place it down in a prescribed ordered fashion ready for transport to the next manufacturing or finishing process. The computer controlled robot arm, which can be a standard light-weight industrial robot, will be fitted with special purpose gripper systems which will enable reliable handling of these delicate flexible materials without damage. Machine vision systems are actually more economic thanks to advanced in sensor, lighting techniques and computing power. In particular, specific project objectives are: a) to increase the competitiveness of European SMEs and reach a satisfactory market situation; b) to increase the safety of the working environment according
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'For a rapid transition to Smart Grids' (GridEye), addressing dissemination and exploitation.

assistant: **Impact**

The proliferation of prosumers and the increase of DERs (distributed renewable, e-mobility, etc.) in distribution grids cause numerous problems to DSOs such as grid instability and supply insecurity, lack of visibility, and difficulty to manage and plan an ever growing grid. So far, unlike high voltage transmission system operators (TSOs), it has not been essential for DSOs to monitor their grids because of the unidirectional power flows and the over-sizing of these grids infrastructures that have allowed to operate them in a safe way. By the increase of DERs and without monitoring systems, it is difficult for DSOs to ensure the reliability and the quality of services while maintaining a limited cost for the grid infrastructure investments. A Smart Electricity Grid is an upgraded active electricity network including information and communication technologies, advanced control, IoT, etc. It can intelligently integrate the actions of ‘prosumers’ able to produce electricity as well as consume it. A smart grid ensures an efficient, sustainable electricity supply, with lower losses and greater reliability and security and solves the main problems associated with the integration onto the conventional distribution network of a great deal of variable and/or intermittent DERs. GridEye allows the rapid transition from the conventional low-voltage grid to a smart distribution grid. GridEye is a true network optimization platform, measuring, monitoring and controlling the low-voltage grid for an efficient integration of DERs. GridEye platform is made up of distributed inter-connected smart modules that measure network quantities and take expert actions to guarantee network power quality and optimization of energy flows. GridEye has been developed by DEPsys a Swiss SME that provides
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spam in Internet Telephony Detection Services' in the context of a Sixth Framework call.

assistant: **Objectives**

With Voice over IP calls being offered for free or for a flat rate, Spam over Internet Telephony (SPIT) has the same potential to become a major annoyance for users worldwide as it is the current situation with e-mail spam. In SPIDER will be delivering a solution to detect and prevent unsolicited VoIP calls and instant messages. This solution will not only be designed to achieve a high detection rate but it will also be optimized to be resource efficient as well. The design of the SPIDER SPIT prevention tools will be based on two aspects. On the one side we will be benefiting from well-known SPAM prevention technologies such as white and black lists or filtering algorithms. These technologies will be investigated so as to assess their suitability for VoIP and be adjusted to take into account the details of the VoIP technologies and systems. On the other side novel approaches based that are derived from the VoIP technology itself such as inter-provider peering mechanisms or security enhancements for the used signalling protocols will be investigated and developed as well.The knowledge and tools gained from current and innovative schemes will then be combined into the SPIDER anti-SPIT solution so as to provide users and service provides a customizable and configurable platform that takes both the needs and capabilities of large service providers as well as single users into account. To assess the efficiency and usability of the developed tools and mechanisms, the SPIDER SPIT prevention system will be intensively tested and probed throughout the project by deploying it in SPIDER partners?  service offering. Thereby, in the context of SPIDER a set of tools and mechanisms will be designed and developed that enable the participating partners to roll-out products and services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A pipeline for the discovery, sustainable production and commercial utilisation of known and novel high-value triterpenes with new or superior biological activities' (TriForC).

assistant: **Concept**

Mankind is continually screening low-molecular-weight compounds from a plethora of synthetic and natural sources in the search for molecules with novel or superior pharmaceutical, agrochemical or other biological activities. In this regard, plants are a potentially rich source of bioactive molecules. Because of their extreme diversity and complex chemistry, however, plant metabolism is still underexplored. Consequently, the full potential of plant-derived, low-molecular weight, bioactive compounds is still largely untapped.The TriForC consortium will tackle this issue by establishing an integrative and innovative pipeline for the exploitation of plant triterpenes, one of the largest classes of plant bioactive compounds with an astonishing array of structural diversity and spectrum of biological activities. The TriForC partners each bring to the consortium the necessary tools, resources, methods and production systems required to assemble the pipeline and produce high value plant bioactives for commercialisation for use as e.g. new drugs or agrochemicals.The TriForC consortia will identify new bioactive triterpenes from natural resources by exploring biodiversity. To increase diversity and bioactivity, new-to-nature triterpenes will be derived by semi-synthesis and by an elaborate metabolic engineering platform in plant and microalgal bioreactor-based production systems. To unleash the potential of triterpenes for green biotechnology, structure-activity relationships for triterpenoids will be explored via high throughput screenings for novel chemical entities with potential agrochemical and pharmacological applications. TriForC will further develop and upscale plant-based bioreactors for sustainable commercial production and bio-refining of high-value triterpenes. The Tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Virtualisation of the testing environment'.

assistant: **Objectives**

The VITE proposal is addressed to the call S2R-OC-IP2-02-2015-IT virtualization of testing environment. The main objective of VITE proposal is to reduce on-site tests for signalling systems leading to reducing overall testing costs. To achieve this main objective the work is organized in two main streams:First, to propose a testing framework by carefully analysing user’s needs and current situation and from there building a process that can be accepted by all railway stakeholders and whose main strength will be to perform as many tests as possible in the lab. An analysis of uncertainties and a simulation of GSMR QoS as well as a proposed methodology for test protocols optimisation will also be addressed.Secondly, to propose a standard architecture for the lab testing including the interface specifications for both the connection between real equipment and the lab tools as for the connection between different labs for remote testing. This architecture will be developed together with some SW tools that will help to automatise lab testing.To validate the test process framework and the lab architecture demonstrations by the participating labs using real track and train data from three of the most significant European countries deploying ETCS (Spain, Italy and Belgium), as well as an assessment by NoBos, DeBos and users from these three countries are also foreseen.Finally VITE has some dissemination and coordination actions to ensure the success and usefulness of the project in particular regarding the coordination with S2R-CFM-IP2-01-2015 and other S2R initiatives.The expected impact of the project is to significantly contribute to the development of a Zero Onsite testing environment.The VITE consortium involves users (RU and IM), independent labs, NoBos/DeBos and engineeri