RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Resolving Surface Reactions in Plasma Catalysis:  Towards Rational Catalyst Design' to be submitted under Horizon Europe.

assistant: **Abstract**

Renewable energy is key to tackling climate change and reducing our dependence on fossil fuels. The intermittent supply of renewable energy hampers its efficient usage and creates a pressing need for innovative energy conversion approaches. Energy-to-fuel conversion using plasma-assisted catalytic conversion (PLAC) is highly promising for producing urgently needed fuels from greenhouse gases. In PLAC, reactants are activated in a plasma discharge, allowing for remarkable efficiencies beyond the limits of thermal catalysis. The catalyst surface defines the reaction pathway and selectivity, and is thus key in catalyst design. However, at present the active state of catalyst surfaces in plasma is unknown, limiting the impact of PLAC by inhibiting the design of dedicated plasma catalysts. In SURPLAS, I will overcome this challenge and unlock the full potential of PLAC by determining the surface reaction mechanisms of catalysts in plasma and demonstrating the rational design of plasma catalysts for CO2 hydrogenation. My expertise in surface reactions, materials design, and in situ spectroscopy forms the basis of a pioneering approach to analyzing surfaces while they are exposed to microwave plasma. My groups unique embedding with plasma experts from industry and academia will facilitate the study of complex catalyst-plasma interactions. I will be the first to determine the active state of single-crystal surfaces and applied powder catalysts in plasma and to derive trends in selectivity and metal-support interactions in PLAC. This breakthrough in understanding will allow for the rational design of plasma catalysts, which I will validate by catalytic performance measurements.This project will revolutionize PLAC by demonstrating catalyst design based on atomic-scale understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Online monitoring and in situ control of epitaxy metal organic chemical vapor deposition - isce-mocvd -' under Fifth Framework.

assistant: **Concept**

Metal organic Chemical Vapour deposition (MOCVD) is a key manufacturing process for microelectronic and optic-electronic devices. However, in a MOCVD production process the deposition process is not monitorable, nor due to a lack of in-process mononitoring closed loop controllable. We focus on in site monitoring of the MOCVD process for the two material systems, which are the industrially most requested: alternary and quaternary {al , ga , in} -{as , p sb} semi conductors for optical communication applications and b) on gallium nitride (GAN) and related materials, which have promising applications for blue laser diodes, high power microwave semi conductor devices ect. This project aims on using, improving, combining and developing real time monitoring techniques and closed loop feedback control of epitaxial growth, where the sensors in site used are purely optical ones, compatible with different industrially used MOCVD growth systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Electric starting torque with short term supercapacitor energy storage for boosting small lightweight gasoline engine powertrains; target action k - storage of energy (EST)' (EST).

assistant: **Innovation**

Electric energy storage by super capacitors and a permanent magnet machine shall improve the drive away and accelerate behaviour of passenger cars with small-downsized gasoline engines. Downsized supercharged gasoline engines are able to improve the fuel consumption up to 30% compared to base engine with about 40% higher displacement and equal power output. Their drawback is the very low torque at low engine speeds resulting in an unacceptable drive away and acceleration behaviour. Electric power train boosting for less than 3s improves the drive away and acceleration significantly. A super capacitor unit with an electrical torque boost device will be designed and installed into a vehicle equipped with a downsized turbocharged gasoline engine. The validation car with torque control management will be tested in the NEDC .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BIOlogical therapy CYCLEs towards tailored, needs-driven, safer and cost-effective management of Crohn’s disease' to be submitted under Horizon 2020.

assistant: **Abstract**

The BIOCYCLE Project proposes to test and critically assess the benefits and risks of an innovative regimen for improving the treatment of Crohn’s disease (CD), a chronic immune-mediated inflammatory disease affecting the gastro-intestinal tract of an increasing number of patients. Currently, the combination of anti-TNFα monoclonal antibodies and immunosuppressants used without interruption is the gold standard for treating CD. However, long treatments are needed which raise safety concerns and costs. For maintaining the same level of efficacy while reducing risks and costs, the idea of BIOCYCLE is to use a regimen based on ""Treatment Cycles"" characterized by alternating periods where both drugs are administrated and periods where only either anti-TNFα or immunosuppressant is used. The central part of the Project will be a large-scale controlled multi-centric clinical study including 300 patients in EU and USA to test the feasibility of shifting from drugs combination used without interruption (control) to Treatment Cycles (experimental arms). Primary and secondary objectives of the clinical study have already been validated for generating the best qualitative and quantitative data on clinical outcomes, predictors of disease evolution and costs. In parallel, the Project will calculate costs-of-illness associated with the different regimens and will perform surveys among patients, caregivers and healthcare systems representatives to assess their readiness to include/support Treatment Cycles in the clinical practice. This will be the basis of a critical appraisal of Treatment Cycles and guidelines for helping caregivers to decide which treatment regimen best fits the specific needs of their patient. If proven, the benefits of Treatment Cycles for treating CD will be dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INNOVATIVE AND ENHANCED NATURE-BASED SOLUTIONS FOR SUSTAINABLE URBAN WATER CYCLE' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of NICE is to widen the availability of enhanced Natural Based Solutions (NBS) to provide circular urban water solutions. NICE will provide key knowledge for the design and implementation of NBS, closing urban water loops. Solutions will make available reusable water for different purposes, in addition to mitigating pollution and runoff and constituting an attractive and integral part of the urban landscape.NICE strategy will be based on the comprehensive study of existing NBS together with the R&D at lab and the validation at Urban Real Labs (11 URLs and 4 Fellow Sites in 5 EU countries and 2 international locations) of innovative NBS covering the urban water cycle (wastewater, greywater, river basins, stormwater & combined sewer overflow).High-potential technologies such as green walls, vegetated rooftops, rain gardens & hybrid subsurface wetlands will be studied and enhanced with especially tailored bioaugmentation strategies, reactive materials & other filling media, novel design & plants, obtaining highly innovative and efficient urban water NBS.The overall approach encompasses the integration of research, citizens, policy and the economic sector to provide the knowledge-base for the integration of the NBS in the real context, covering technical, geographic, social, economic and cultural variety:• Enable the scaling up NBS across EU by development of guidelines, standards and methodologies. A deep review of the existing innovative urban NBS in EU and beyond as well as the creation and implementation of URLs will be carried out. • New business and investment models to maximize the co-effectiveness and co-benefits for the environment, economy and society in urban landscapes of the development and deploy of NBS solutions.• Identify obstacles, bar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synergic combination of high performance flame retardant based on nano-layered hybrid particles as real alternative to halogen based flame retardant additives' under Seventh Framework.

assistant: **Concept**

Electrical and electronic (EE) applications – including housings, wire and cable, and internals such as connectors– are the largest market for flame retardants (FR) in plastics globally. The need for flame retardancy is increasing due to electronics miniaturization and higher temperatures in both processing and use. PHOENIX project is an ambitious multidisciplinary innovative threefold approach to develop:(i) A new concept of FR nanostructured materials, based on new non-halogenated flame-retardants applying nanotechnology to replace hazardous chemicals to produce sustainable FR additives based on nanolayered structures and modified lignins,  produced with innovative and green chemical routes, for thermoplastic and thermoset applications.(ii) Innovative processing routes, providing solutions to the demands of the EU Industry regarding FR, finding a true cost-effective and sustainable alternative to existing non-environmentally friendly HFR, which allows simultaneously a significant improvement of mechanical properties and processability, highly limited with the existing non-halogenated FR available in the market for compounding, extrusion and injection moulding processes. New compounding techniques such as Nanodirekt process, and high innovative systems, such as ultrasounds mixing systems coupled to extrusion and injection equipments, will assure high nanoparticles dispersion in the polymer nanocomposites and in the final pieces, thus achieving optimal properties.(iii) Simulation and modelling of compounding processes for the preparation of optimal nanocomposites, avoiding aggregates and achieving the best dispersion of the nanoparticles in the polymer matrix.The achievement of these results will represent a significant advantage to the participating SMEs and in turn to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Glioblastoma Subtype Avatar models for Target Discovery and Biology' (2014-2020).

assistant: **Concept**

The Glioblastoma Multiforme (GBM) is the most common primary brain tumor and it is incurable. Two major challenges affect GBM clinical management: its heterogeneity (which treatment will best fit this very patient?) and its resistance to available treatments (will the patient benefit in any way from the chosen therapy?). Here we approach these questions with a personalized entry point. First, we aim to create “humanized” experimental models of GBM accurately reflecting patients at molecular level. These GBM Subtype Avatars models (GSA) will be exploited as “targeted patients” in personalized biology and intervention studies. Since GBM exists as molecular subtypes with similar histopathology but mutually exclusive genetic lesions and molecular features, we will generate GSA by targeting mutations recurrently associated with Proneural, Classical or Mesenchymal GBM subtypes into adult human neural stem cells (NSC). Evidence supports that these cells can give rise to high-grade gliomas when engineered with the appropriate genetic lesions. Next, engineered NSC will be orthotopically implanted into immunocompromised rats and the resulting tumors profiled for gene expression, DNA methylation and copy number aberrations. These profiles will be compared to those generated in patient-derived xenografts and biopsies. Second, to identify drug targets favoring patients’ response to the current standard of care, we will exploit GSA for state-of-art genetic screens in vivo. Specifically, we will seek for synthetic lethal interactions between DNA damaging agents and the GSA transcriptome using an in vivo CRISPRi screening approach. Third, to investigate the molecular basis of GBM heterogeneity in GSA models, we will combine genetic and immunophenotypic tracing with gene expression and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Comparing Audiovisual Neural Signals Across Environments and Disease-Models' (FreeMovementAV).

assistant: **Innovation**

To form representations of the world, brains combine information across sensory modalities. Audiovisual integration, combining auditory and visual information, is an extensively studied example of this process, in part because atypical audiovisual integration is linked to cognitive conditions including schizophrenia and autism spectrum disorder (ASD). However, recent rodent studies are conflicted regarding the regions and mechanisms of audiovisual integration, and this may derive from changes in neural processing caused by different experimental environments: head-fixed or free-movement. Technical challenges in stimulus delivery and longitudinal recording have prohibited neural recordings in the same animals across these conditions. Consequently, because mouse disease-models rarely tolerate head-fixation, they have not been used to test audiovisual hypotheses generated through clinical studies in humans. In this project, I will overcome these hurdles with the host lab, using a novel audiovisual arena I developed to present controlled stimuli to freely-moving mice. First, using wild-type (WT) mice, I will determine the impact of head-fixation versus free-movement on basic audiovisual processing using the host lab’s electrophysiology implant to track neurons for months. Second, I will compare these WT data with recordings from a freely-moving ASD mouse model, to test the hypothesis that ASD presents with excessive audiovisual integration. Finally, I will compare WT and ASD neural responses in mice learning spatial audiovisual reward-association to determine whether differences in passive audiovisual processing correspond to changes in learning. This project represents the first characterization of environment-dependent audiovisual processing, and the first extension of au
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Photonic Integrated Multi-Channel Telecommunication Optical frequency Comb' to be submitted under Horizon 2020.

assistant: **Abstract**

Over the past years the Laboratory of Phonics and Quantum Measurements (LPQM) has developed a photonic chip that generates ultrashort pulses at 10-100 GHz mode spacing and is capable to spectrally cover all the telecommunication bands for high speed telecommunication testing applications, in contrast to existing products that usually only cover one band. Our fabrication base is a well-established semiconductor technology, expanded through innovative processes to cover the needs of optics developed from zero until now at EPFL. This gives a cost advantage due to integration and high reliability thanks to miniaturization. We propose to develop over the next 18 months a product prototype and marketing strategy of a chip based optical frequency comb (OFC) that can be used for broadband (i.e. > 50 terahertz) coherent telecommunication test device characterization with detectable line spacing of tens of gigahertz. Potential future customers would be telecommunication companies, network providers and R&D labs that could use the devices as both receiver and multi-channel local oscillator for coherent telecommunication architectures for both long haul and metro applications. The aim of this project is to analyse the market opportunities, understand the needs of potential end-users, identify the most promising market segments and identify those elements that will comprise the pricing for a product beyond the demonstrator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Creutzfeldt-Jakob disease in the European Union - Incidence and risk factors' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Through the BIOMED1 programme, a grant was awarded for the co-ordination of Creutzfeldt-Jakob Disease (CJD) surveillance programmes in the European Union. National registries of CJD have been established in France, Italy, Germany, the Netherlands, Slovakia, Spain and the UK, and these project now share common diagnostic criteria and research methodologies. This harmonisation of projects has provided a unique framework to study putative risk factors for Creutzfeldt-Jakob disease, a disease of great potential public health and economic importance, following the occurrence of Bovine Spongifor Encephalopathy (BSE) and the description of a new variant of CJD which may potentially be causally linked to BSE. The new objectives of the current proposal are: 1. To focus on the incidence of new variant CJD (NVCJD) in the EU and to analyse potential risk factors for this condition. Also to compare the incidence of NVCJD in Switzerland, a country with a low incidence of BSE and also in Canada and Australia, countries in which exposure to BSE is likely to have been minimal. 2. To study new diagnostic tests for CJD including CSF markers. 3. To provide material, including tissue samples, from well documented cases of CJD for other research projects in the EU, eg markers of infection in prion disease and transmission studies. 4. To develop educational material for relatives of patients and to provide information to the general public. Continuing objectives are: 1. To study for trends in the incidence of CJD by the co-ordination of national registries of CJD in the EU. 2. To assess putative risk factors for CJD including past medical history, occupation, and diet. 3. To study the clinicopathological variants of CJD with reference to the influence of genetic and environmental factors on d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Installation permitting guidance for hydrogen and fuel cells stationary applications'.

assistant: **Concept**

The universally recognised need to curb greenhouse gas emissions and secure a cheap and environmentally friendly supply of energy is a major economic and social driver that can be met by hydrogen and fuel cell technologies. The Installation Permitting Guidance (IPG) for Hydrogen and Fuel Cell Stationary Applications (HYPER) project is aimed at developing for small stationary hydrogen and fuel cell systems to fast track approval of safety and procedural issues, by providing a comprehensive agreed installation permitting process for developers, design engineers, manufacturers, installers and authorities having jurisdiction. To achieve this objective the project brings together a group of 27 organisations, made up of 15 partners and 12 members of a supporting Monitoring and Implementation Group. The partners include hydrogen system and fuel-cell manufacturers, installers and operators, regulators, research laboratories and universities.The Group has a complementary make up and includes Industrial Associations, hydrogen distributors and an aerospace company. To develop the IPG the consortium will bring together all currently available documents, best practice and experience and identify and fill gaps in current knowledge. The workprogramme includes: detailed case studies of representative fuel-cell and hydrogen installations carefully selected from across Europe, USA and Canada; modelling and experimental risk-evaluation studies to investigate fire and explosion phenomena associated with foreseeable and catastrophic fault scenarios of hydrogen and fuel cell systems and associated fuel supplies; a three stage drafting process for the IPG, which will take feedback from interested stakeholders; a number of carefully targeted dissemination initiatives will be taken in order to