RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Gastrointestinal Tract on Chip - An automated microfluidics-based modular device for complete simulation of the processes of digestion and absorption of orally ingested bioactive compounds'.

assistant: **Concept**

People can only ingest food through the oral cavity, and oral administration remains the preferred route for the delivery of drugs or dietary supplements. However, orally ingested compounds must first survive digestion and then be absorbed at the small intestine to reach the systemic circulation. This proposal aims to develop and fabricate the first automated microfluidics-based device for complete simulation of the processes of digestion and intestinal absorption of orally ingested bioactive compounds. The innovation lies on the capacity to simulate the process in full and, on the introduction of integrated sensors for online, real-time monitoring of the pH, barrier integrity, intestinal permeation and cellular responses. In addition, the use of primary cells will allow to create disease models and patient-specific tissues for personalised medicine. Co-cultures with the gut microbiome will allow to assess the effect of the ingested compounds on commensal bacteria and of the latter in nutrient digestion. The work will be conducted at the International Iberian Nanotechnology Laboratory in Portugal, with two secondments projected at the University of Southampton for 4 months, and intersectorally at GlaxoSmithKline, in Stevenage, UK for 2 months. The device will offer the possibility to study minute sample amounts, with high resolution and with the potential for high-throughput analysis, which is key for its adoption by large pharmaceutical and food industries with high economic and social impact. The proposal aligns with the societal challenges 1 (Health, demographic change and wellbeing) and 2 (Food security) of the current Horizon 2020 work programme. The work is multidisciplinary and the combination of learning through research and a comprehensive training plan will st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanoparticle development for molecular imaging and drug delivery' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed research will explore new strategies in nanomedicine and develop novel materials for drug delivery, molecular imaging, proteomics and metabolomics.  The four main objectives can be summarized as nanoparticle assembly, application of nanoparticles to molecular imaging, novel ligand design for drug delivery and viral detection and inhibition.  Assembly of nanoparticles into unique signalling platforms will be achieved via novel ligand design for gold and silver nanoparticles and will enhance the utility of such particles towards molecular imaging. Success will make vibrational microscopy using functionalized nanoparticles a viable alternative to fluorescent probes for medical imaging.Applications in molecular imaging will focus on visualizing proteins at the surface of neurons with glycosylated nanoparticles to understand how these signalling proteins change in number and localization in response to stimuli and how these protein traits vary between healthy and diseased neurons.  These data are critical in understanding the causes and progression of neurodegenerative diseases.  This research will result in novel opportunities for therapeutic intervention, which itself may be possible using the functionalized nanoparticles as drug delivery agents.  Glycosylation of the surface of the nanoparticles is critical for improving the bioavailability of nanoparticles for this objective.  In the third objective of this project, photo-cleavable groups will be introduced into the nanoparticle ligand framework and used to release drugs at targets upon two-photon excitation of the nanoparticles. Thereby a single photon is emitted that can cleave the photo-labile group binding the drug to the particle.Finally, glycosylated nanoparticles will be used to image hepatitis C vira
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'STING - A Soft Tissue Intervention and Neurosurgical Probe'.

assistant: **Objectives**

Current trends in surgical intervention favour a minimally invasive (MI) approach, in which complex procedures are performed through increasingly small incisions. Significant technological advancements have been made in the area of endoluminal surgery, where natural orifices and accessible vessels are used to direct MI instruments to the target (e.g. endoscopes and endovascular catheters). In contrast, progress on the development of percutaneous instruments has been slow and new approaches need to be explored. Steerable needles and probes able to follow complex trajectories through soft tissue would have a significant impact on the effectiveness and safety of conventional MI procedures and especially on the development of new treatments which will follow on from advancements in medical imaging, tissue engineering and genetics.This project aims to deliver a biologically-inspired system for MI surgery, capable of automatically steering towards and targeting specific soft tissue areas deep within the body. A total system suitable for clinical application will be investigated, but taken only to final prototype stage through laboratory trials. The system will be applicable to a range of soft tissue applications (e.g. brachytherapy, drug delivery, etc.), but key demonstrators will be in the areas of liver and neurosurgery. Every aspect of the system will be modelled, including the complex interaction between the probe and the surrounding soft tissue, with an aim to optimise the design for the two demonstrators and to develop a comprehensive research platform to aid future application-specific research on the bio-inspired design. As an adjunct to this work, which will broaden the range of viable future applications to the area of interventional imaging, MRI-compatibility will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In situ saturation monitoring in core samples by electrical impedance tomography' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project aims to develop instrumentation and software to greatly increase the value of measurements made on hydrocarbon reservoir core samples. It will improve the accuracy of petrophysical measurements on the rocks, and lead to a better understanding of fluid-rock interactions by quantifying and visualising fluid distribution during dynamic flow experiments. The main technical objective is to develop tomographic measurement techniques and associated reconstruction algorithms to enable the 3-dimentional imaging and quantification of real-time or near real-time fluid distribution within core samples under reservoir pressdure conditions through Electrical Impedance Tomography (EIT). The samples which will be used are standard cylindrical core plugs with a diameter of 38 mm. The research aims to develop equipment which will provide resolution on the millimetre scale. The proposal outlines the use of PC based simulation and reconstruction software to investigate the performance of reconstruction algorithms and to select schemes for exitation and measurement. This will provide the basis for the development of an electrode array to be applied to the cylindrical surface of the sample, and the measurement electronics, which will allow four wire measurements with shaped exitation patterns at appropriate speeds. Initially well established but restricted linear reconstruction algorithms will be used as a basis for comparison, then progressed to non-linear iterative reconstructions incorporating various constraints. After the development of a working 2-dimensional prototype the possibility of full 3-dimensional tomography, using axial as well as transverse current flow, will be investigated. The potential for paralled implementation of the algorithms will be explored using paral
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Migratory 1,n-fluoroalkylcarboxylation of non-activated alkenes via dual photoredox/ Nickel catalysis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Catalytic chain-walking reactions have recently emerged as a powerful tool for efficiently introducing functionalities at remote sp3 C–H sites within alkyl side chains. Nevertheless, substantial challenges remain when forging multiple C–C bonds while maintaining a predictable site-selectivity profile in chain-walking scenarios, particularly by controlling both regioselectivity and enantioselectivity. This project will explore the ability to introduce both fluorinated fragments and CO2 at an unsaturated hydrocarbon via dual photoredox/nickel catalysis with a predictable selectivity pattern. Such a transformation constitutes an unrecognized opportunity in chain-walking scenarios for introducing, at will, fluorinated fragments and carboxylic acid functions in a dual, yet modular, site-selective manner. Aimed at exploring the full potential of such an approach for accessing added-value fluoroalkyl carboxylic acids, a new class of C2-symmetric ligands will be rationally designed and developed. The impact that this technique might have in industrial endeavors will be assessed in collaboration with industrial partners of the host group by its application in late-stage modification of advanced intermediates, radiolabeling, and the synthesis of MRI probes.


**Keywords:** Nickel catalysis, Chain-walking, Carbon dioxide fixation, Difunctionalization, C-H functionalization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Reduced Order Methods with Applications in Computational Fluid Dynamics' (AROMA-CFD).

assistant: **Innovation**

The aim of AROMA-CFD is to create a team of scientists at SISSA for the development of Advanced Reduced Order Modelling techniques with a focus in Computational Fluid Dynamics (CFD), in order to face and overcome many current limitations of the state of the art and improve the capabilities of reduced order methodologies for more demanding applications in industrial, medical and applied sciences contexts. AROMA-CFD deals with strong methodological developments in numerical analysis, with a special emphasis on mathematical modelling and extensive exploitation of computational science and engineering. Several tasks have been identified to tackle important problems and open questions in reduced order modelling: study of bifurcations and instabilities in flows, increasing Reynolds number and guaranteeing stability, moving towards turbulent flows, considering complex geometrical parametrizations of shapes as computational domains into extended networks. A reduced computational and geometrical framework will be developed for nonlinear inverse problems, focusing on optimal flow control, shape optimization and uncertainty quantification. Further, all the advanced developments in reduced order modelling for CFD will be delivered for applications in multiphysics, such as fluid-structure interaction problems and general coupled phenomena involving inviscid, viscous and thermal flows, solids and porous media. The advanced developed  framework within AROMA-CFD will provide attractive capabilities for several industrial and medical applications (e.g. aeronautical, mechanical, naval, off-shore, wind, sport, biomedical engineering, and cardiovascular surgery as well), combining high performance computing (in dedicated supercomputing centers) and advanced reduced order modelling (in comm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Characterization of antibiotic-resistant bacteria in food-producing animals.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Mediterranean Agronomic Institute of Chania Biochemistry Research Group POST-DOCTORAL RESEARCH ASSOCIATE Applications are invited for a Post-doctoral Research Associate to work in the laboratory of Dr Sotirios C. Kampranis on the characterization of antibiotic-resistant bacteria in food-producing animals. The post, which is funded by the European Union, Marie-Curie Host Development Fellowships, is to isolate antibiotic-resistant bacterial strains from food-producing animals and to characterize the molecular basis of resistance. Suitable applicants should be experienced in microbiology of bacterial resistance. The post is available from January 2002 for two years. Details of the research programme of the laboratory can be obtained on the web at (http://www.maich.gr). Applications should include a full CV and the names and addresses of two referees and should be directed to Dr. Sotirios C. Kampranis at the Mediterranean Agronomic Institute, Alsyllion Agrokepiou, Chania 73100, Crete, Greece (e-mail: sotirios@maich.gr).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Changing land usage enhancement of biodiversity and ecosystem development'.

assistant: **Concept**

To study the effects of community complexity (of both vegetation and soil (micro) organisms) on ecosystems processes and vegetation dynamics on former agricultural, set-aside, land. - To examine if the complexity of the community on set-aside agricultural land can be enhanced artificially by increasing plant species diversity. - To examine if, and how, a stepping stone approach may be used to enhance the colonisation of the soil of set-aside land by soil (micro)organisms of expected/desired successional stages. - To study the effects of community complexity, as well as manipulation of community development by increasing plant species diversity and by applying stepping stones in a north-south and east-west double gradient to get results applicable at a European scale. - To contribute to the Terrestrial Ecosystem Research Initiative (TERI) of the European Union by establishing field sites that may be used for studying effects of changing land use, biodiversity and species interactions on ecosystem processes and ecosystem development.Key processes enhancing the transformation of set-aside agricultural land into restored natural ecosystems will  be examined by six partners, offering expertise in plants and soil organisms, as well as biogeochemical cycles  of nutrients, affecting biodiversity-related interactions and ecosystem processes.  The soil biota involved concern bacteria, fungi (incl.endo- and ecyomycorrhizae), nematodes, insects and earth  worms.  Six countries participate in CLUE: Sweden, the Netherlands, France, Spain (representing a north-south gradient)  and the Czech Republic and England (representing the extremes of the east-west gradient) to obtain results  applicable at an European scale. The CLUE project team is organized interdisciplinary and each particip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The development and verification of a novel modular air cooled condenser for enhanced concentrated solar power generation' (MACCSOL) targeting Seventh Framework.

assistant: **Abstract**

This project will develop and verify a novel modular air cooled condenser (MACC) for concentrated solar power (CSP) plants. This technology will enable CSP plants to increase net power output, and reduce costs compared to existing dry cooled plants. Conventional dry cooling is unresponsive to changes in ambient conditions. However, the MACC will incorporate sensors which detect changes in temperature, ambient wind, and fan flow rate, and control algorithms, which will communicate with these sensors to continuously vary fan speed. The MACC will therefore maintain optimum condenser pressure and temperature irrespective of ambient conditions. As a result, turbine outlet conditions will always be optimised, thus maximising power output and reducing operating costs. Also, because the MACC is modular, installation and maintenance costs will be significantly reduced.The project will first optimise and characterise the performance at module level. Fan control algorithms will be developed and interfaced with temperature and flow sensors which will be developed. At system level, module layouts will be investigated to assess the possibility of harnessing the wind to assist fan operation. Both system and module level development will involve numerical simulation, analytical modelling, physical scale modelling, and measurements on full scale prototypes. The effects of all design options will be assessed using thermodynamic models. Techno-economic modelling will assess the life time cost implications of various design options. To prove the merits of the MACC, full scale testing in an operational CSP plant will be performed. The main outputs of the project will be patented MACC designs, an industrial scale prototype, and dissemination of project activities to ensure a lasting project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Validating hydrological moderocess studies and internal data from research basins: tools for assessing hydrological impacts of environmental change.' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To improve hydrological modelling approaches, through identifying model weaknesses in reproducing actual internal catchment processes as well as investigating parameter variability, and to progress in understanding hydrological processes, through improved field observation and issues arising from modelling queries and outputs. The long-term objective is to provide reliable tools for assessing the hydrological consequences of environmental change and defining the land and watershed management strategies necessary to preserve water quantity and quality.A physically-based hydrological model (SHETRAN) and a parsimonious model (TOPMODEL) will be validated and improved using data from small experimental catchments, including work to ensure that the internal dynamics and processes of the catchments are properly represented. Submodels for precipitation interception in forests and for snow melting will be specially developed. A new generation of field techniques, including TDR (Time Domain Reflectometry), GPR (Ground Probing Radar) and GPS (Global Positioning System), are to be tested and used together with other field experiments to obtain data for internal validation of subsurface hydrology in small research catchments. The methodology for hydrological use of GPR at the hillslope and small catchment scales (soil water content, soil water reserve and water table delineation) will be developed through validation in a range of field conditions. Joint field campaigns are to be performed in the Vallcebre catchments (Southeast Pyrenees), an area with strong spatial and temporal heterogeneities in hydrological characteristics and process operation. The purpose of these campaigns is not only to gather field data, but also to create the best conditions for exchanging experience between
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rethinking Urban Nature' to be submitted under Seventh Framework.

assistant: **Abstract**

This ground-breaking project will challenge existing understandings of urban nature using an innovative interdisciplinary framework in a comparative international context.  The project provides a new theoretical approach that moves beyond existing approaches to provide a novel synthesis between advances in urban ecology and original insights into cultural and political dimensions to the production of urban space.  My core hypothesis is that in order to understand the dynamics of urban nature we must link the independent agency of nature with a renewed urban environmental history that takes full account of changing conceptions of human subjectivity, the ideological dimensions to scientific metaphors, and the need to develop new critical engagements with the global South.  Using four cities as case studies — London, Berlin, Tallinn, and Chennai — the project will show that a theoretically nuanced and historically grounded exploration of the intersections between critical urban discourses and recent advances in urban ecology provides a vital counterpoint to narrowly utilitarian approaches to urban nature.  In addition to a series of academic outputs the project will also create a documentary film, an exhibition, a website, and a series of workshops and public events.