RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling the role of salivary microbiota on retronasal aroma, aroma perception and liking during food consumption in obese individuals as a strategy to support healthier nutrition' under Horizon 2020.

assistant: **Concept**

During eating, aroma compounds and its precursors are released from the food and dissolved in saliva where they are susceptible to be metabolised by salivary microbiota. This will affect the type and rate of aroma compounds reaching the olfactory receptors (retronasal aroma), thus aroma perception and food liking. Scientific evidences suggest that obesity provokes an alteration in salivary microbiota, which could provoke an unbalanced aroma perception altering food preferences and compromising food consumption behaviour. Since obesity has become a truly global epidemic (affecting all countries and populations of all income levels) for which no effective solution has been found, AROMABIOTA proposes an innovative interdisciplinary approach to evaluate the implication of differences in salivary microbiota associated to obesity on retronasal aroma, aroma perception and the hedonic response against food in an attempt to decipher the mechanisms influencing food consumption behaviour. A panel formed by normoweight and obese individuals (n=100) balanced by gender will be set up. Salivary microbiota profiles will be determined by using metagenomics and enzyme activities by using state-of-the-art biochemistry methods. Ground-breaking physioanalytical techniques and sensory techniques will be employed to monitor retronasal aroma, aroma perception and food liking during consumption. Finally, physioanalytical and sensory data will be correlated with microbiological data to propose sensory phylotypes associated to obesity, unravelling for the first time the connections between the microbiota-mouth-brain axis. AROMABIOTA is in line with the Objective “Good Health and Well-Being” of the Sustainable Development Goals from United Nations and will provide the applicant with the necessary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Strengthening eInclusion and eAccessibility across Europe'.

assistant: **Concept**

This coordination action provides scientific support to a key policy objective - ensuring that EVERY citizen has the opportunity to benefit from the Information Society. It develops innovative policy approaches that accelerate progress towards comprehensive eInclusion/eAccessibility in the context of Europe 2005 roadmap and beyond. Through the coordination of research and facilitation of an informed dialogue between key stakeholders, these objectives will be realised:- development of a research and policy framework that will support a common understanding of the eInclusion and accessibility concepts/policy aspects amongst all stakeholders in an European Research and Policy Area (ERPA), including Acs establishment of a comprehensive empirical knowledge base to support all aspects of the policy-making process in relation to eAccessibility/eInclusion, thereby focusing on three topical areas: a) eAccessibility issues emerging from the eEurope 2005 action plan, electronic communication and other policy frameworks; b) eAccess to employment, re-skilling for disabled citizens, etc.; c) eAccess to online public services (such as eGovernment, eHealth)- development of a vision of the new opportunities and threats posed by emerging technologies to support proactive policy formulation- design and implementation of a robust dialogue mechanism involving institutions, groups and actors from all relevant policy fields identification of best practice" examples of policies on eInclusion/eAccessibility, based on rigorously defined criteria and consensus amongst stakeholders- recommendations for practicable policy strategies and implementation measures - with realistic and achievable goals developed in dialogue with the research community and stakeholders across the Union and all ACs.- diss
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Shaping the future bioeconomy across sectoral, governmental and geographical levels', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The overall aim of ShapingBio is to support and accelerate bioeconomy innovation and the deployment of new knowledge in the EU and its member states. ShapingBio aims to provide evidence-based and concrete information and recommendations for better policy alignment and stakeholder actions to realize the cross-sectoral potential of the bioeconomy and to reduce the fragmentation across bio-based sectors and food system and policies across regions, domains and governance levels. These actions contribute significantly to the bioeconomy strategy and Action Plan, the farm to fork strategy, the EU Green Deal policy priorities and the EU's Climate ambition for 2030 and 2050.For that purpose, ShapingBio aims to create a better understanding and information basis of the bioeconomy innovation eco-system by providing a comprehensive mapping and analysis of initiatives, structures, policy instruments and key gaps related to the topics policy and governance, applied R&D and technology transfer, (cross-sectoral) collaboration and financing across the EU macro-regions and different sectors. This will be carried out in close collaboration with various types of stakeholders from different sectors, by ensuring the involvement of all the relevant actors. Multi-actor groups will be set up to support policy advice design, but also to propose new forms of matchmaking, networking and knowledge-transfer. Those propositions will be implemented and tested in around twenty events. Based on these actions, recommendations for an effective governance in terms of policy instrument and their mixes will be derived as well as guidelines for different stakeholder groups for better collaboration and exploitation of bioeconomy innovations. Follow-up events will be conducted, to ensure that the recommendation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synergizing enhanced radiotherapy with tumor-associated macrophages-targeted immunotherapy in glioblastoma with multimodal therapeutic nanoparticles' to be submitted under Horizon Europe.

assistant: **Abstract**

In glioblastoma (GBM), intrinsic and environmental factors are limiting the efficacy of radiation therapy (RT) and immunotherapy. These factors include intrinsic cancer cells resistance, hypoxia, and the presence of immunosuppressive cells such as tumorassociated macrophages (TAMs).Considering these current limitations for RT efficacy and the specific deleterious role of TAMs in GBM, I designed an original therapeutic strategy combining enhanced RT and TAMs reprogramming with toll-like receptors (TLRs) agonists to synergize direct cytotoxicity to tumors cells at low radiation doses with immunotherapy for both local and recurrent tumor rejection. For this, I will use relevant radio-sensitizing moieties for GBM: high Z atoms which can efficiently absorb, scatter, and emit radiation energy and catalase, an enzyme capable of converting H2O2 to oxygen in the tumor microenvironment (TME). It will be simultaneously applied with the combination of the TLRs agonists poly(I:C) and resiquimod, which will be used to re-educate TAMs and prepare the TME to a strong anti-tumoral immune response. The selected molecules will be incorporated in a new Multimodal Therapeutic NanoParticle (MTNP), based on a nanosized zeolite structure, allowing to combine the two approaches in a unique particle.The MTNPs will be tested in vitro and in vivo in murine model of GBM and patient-derived samples, to verify their effectiveness in enhancing RT and reeducating TAMs, and their effect on tumor growth. The present multidisciplinary research program aims at supporting greater progress in the treatment of brain tumors and ultimately leading to improved outcomes for cancer patients.


**Keywords:** Glioblatoma,  Nanosized Zeolites,  Tumor-associated macrophages,  TLRs agonists,  Radiosensitizers,  Hypoxia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TOWARDS AN ALLIANCE OF EUROPEAN RESEARCH FLEETS' (EUROFLEETS), addressing dissemination and exploitation.

assistant: **Impact**

The quality of the infrastructures available for marine research affects directly Europe research performance. So marine research infrastructures are considered as key elements of the European Strategy for Marine Research under development. A coherent pan-European approach with enhanced partnership in investment, development and usage of fleets, will have a significant impact to better meet the diverse needs of European marine research. The EUROFLEETS process is based on the recommendations of a recent MB-ESF report. It aims at bringing together the European research fleets owners to enhance their coordination and promote the cost-effective use of their facilities. It will support research services for the monitoring and the sustainable management of the Regional Seas and the Oceans, and will organise a common access to all European scientists on sole condition of scientific excellence. This would enable the EU to reach its ambitious goals about maintaining the ocean biodiversity or understanding climate change. EUROFLEETS aims at: •Working upon common procurement strategy, and build corresponding roadmap on prospective sound bases, •Structuring and durably coordinating, through an e-platform, the way that the research vessels are operated and their interoperability capacities, •Using more cost efficiently the existing European fleets and associated equipment in the frame of the European research Area, •Promoting greener and sustainable research vessel and underwater vehicle operations and design, •Providing all European researchers with access to 19 high performing research vessels from 15 different countries, •Fostering coordinated and joint development of European fleets, thanks to new interoperable software and underwater vehicle payloads, •Developing training and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The early ticking of the central circadian pacemaker: when and how' (StarTicking) under Horizon Europe.

assistant: **Objectives**

The 24-h (circadian) timing system develops during the perinatal period and rules our physiology later in life. It has the essential task of anticipating daily recurring changes in the environment (day/night) to find the best time for each molecular and cellular process. It is organised hierarchically, with a master pacemaker in the hypothalamic suprachiasmatic nucleus (SCN), which is able to perceive environmental light and tell the body what time is it. Our modern 24/7 lifestyle favours a disruptive environment for the circadian system, which is especially negative during pregnancy. We have found, in mice and pre-term infants, that when mothers are exposed to glucocorticoids (GCs) at the wrong time of day, the offspring show behaviour disorders later in life. Our mechanistic findings showed for the first time, a role of the foetal clock before birth, challenging the view on the clock being immature and non-functional.StarTicking proposes to answer a long-standing question in the field: When and how the circadian clock starts ticking. With a multidisciplinary and integrated approach, we will go beyond the state-of-the-art to understand mechanistically the development of the central circadian pacemaker in mice and humans. We will investigate: 1) How the SCN forms by a detailed assessment of the developmental trajectory of the mouse SCN with single cell resolution. 2) When the SCN becomes functional by testing a yet unexplored player: Astrocytes as drivers of the gain of functionality of the mouse SCN.3) What the influence of the early environment on the human SCN maturation is. The generation of a human SCN organoid will allow us to test maternal signals in vitro with high-throughput. We will link mechanistic findings to the development of SCN-driven rhythms in a cohort
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Future Perspectives of Superconducting Josephson Devices' in the context of a Fifth Framework call.

assistant: **Objectives**

The conference will be dedicated to an advanced discussion of the present state-of-art and future perspectives of superconducting Josephson electronic devices with particular attention to their impact in technological and industrial applications. The project will develop along two meetings: the first one will be devoted to the most recent developments in the field of Multi-junction devices, both with Low Critical Temperature (LCT) and High Critical Temperature (HTC) materials. Among the applications we want to mention large square arrays of LTC Josephson junctions (that have been proved capable of coherent emission with significant power delivered above 100 GHz) and the development of HTC devices capable to reach the submillimeter wavelenghts. The second event will be devoted to HTC materials and devices that via the so-called intrinsic Josephson effect, might become the Josephson technology of the future. This is due to the possibility to have intrinsic Josephson junctions in HTC-BISCCO compounds, that in terms of homogeneity and high frequency properties have been proved one of the best type of junctions that can be realised with HTC superconductors. The close link between the two events it is found in the possibility of the use LTC devices to model the behaviour of HTC materials like BISCCO.So the layered structure of BISCCO can be considered, for example, as a stack of superconducting sheets separated by weak links similar to an array of stacked LTC junctions. The topmost leading scientists of the field will be invited to talk about their more recent and original research. Moreover, a fully representative participation of the most prominent European groups working in the sector is expected. In order to have an intense exchange of ideas and competencies between scien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development for new systems for measuring vibration, velocity and distance using the self-mixing phenomenon' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project aims to improve the quality and cost effectiveness of production processes by industrialising distance, displacement and velocity sensors using the self mixing interference in a laser diode. These contactless sensors present advantages in cost and bulk over most of conventional devices. They can be used, whenever possible, during production, to spark off real time corrective actions. They are very suitable for machine tools, hostile environments (hot material, nuclear industry), micromechanics and electronics industry, and more generally, for reliability of production systems, quality control of materials (composite materials, for example), preventive maintenance, aircraft and vehicle design. A major application of the displacement sensor is to help reduce noise for better working conditions. By designing and producing these sensors, the SME proposers will improve their stature as measurement and testing specialists and generate for themselves a wide range of new potential customers. For this purpose, the main tasks are: . the characterisation of the optical sources with feedback . the reduction of the influence of the speckle . the design of prototypes . the adaptation to specific applications according to end user demands. Other industries can benefit indirectly from this project by having access to low cost sensors, very competitive in terms of resolution, to reduce the cost of non destructive testing in order to improve the quality of production processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Methodologies for integrating impact assessment in the field of sustainable development' in the context of a Fifth Framework call.

assistant: **Objectives**

The present proposal puts forward a methodology for integrating impact assessment in the field of sustainable development. The areas covered are climate change, impacts on health, buildings and eco-systems, transport, economic impacts and energy-related issues. At the heart of the approach lies the construction of a tool for policy integration incorporating hedging on a large number of objectives. To achieve its goals, the project involves definition of measurable sustainable development indicators and selection of policy instruments for affecting these indicators, development of tools representing the entire chain from instrument to indicator for the above mentioned areas, evaluation of instrument costs, development of stochastic models of the instrument-to-indicator chain and impact analysis with the aid of a policy integration tool. The results of the analysis will be used for integrated policy exploration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High entropy alloy catalysts for hydrogenation of biomass derived oxygenates' under Horizon Europe.

assistant: **Concept**

In the proposed project, we will study high entropy alloy (HEA) materials as an alternative to noble metals for liquid phase biomass processing. Non noble metal catalysts suffer from stability issues during liquid phase biomass transformation, owing to sintering, oxidation induced leaching, poisoning. Noble metal catalysts are often used in hydrogenation, hydrodeoxygenation reactions of biomass derived oxygenates, making the process expensive, which is one of the reasons why biomass derived products are not widely adopted in industry yet. We believe HEAs of non-noble metals can solve this problem. This project combines the researcher's expertise in material science and advanced characterization methods with the host's knowledge of biomass conversion and is further enriched by the co-supervisor's background in theoretical chemistry. Together, these strengths will drive the development of new sustainable catalytic materials for biomass conversion.


**Keywords:** High entropy alloy, Heterogeneous catalysis, Biomass conversion, Non-noble metal, Spectroscopic characterizations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Impact of three selected biotechnological strategies for potato pathogen control on the indigenous soil microbiota' in the context of a Fifth Framework call.

assistant: **Objectives**

This proposal assesses the ecological impact of three no chemical strategies to control potato pathogens (transgenic lines carrying T4 lysozyme orcecropin/attacin genes, virulent harp mutants of Ralston solanacearurn). Three aspects will be addressed:(1) the impact on the natural micro biota associated with potato,(2) the impact on pathogen genetic diversity, and(3) the efficacy of the strategy. The work will be executed in greenhouses and the field, in a concerted fashion. The fieldwork will be concentrated at 2, i.e. a Northern and a Southern, locations. The Consortium consists of 7 partners with complementary expertise, together with 3 commercial partners and 1 communication specialist. The data will serve to underpin the ecological impact of advanced phytopathogen control strategies and will contribute to the discussion on the use of transgenic plants in Europe.