RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Modular Distributed Drivetrain for Electric/Hybrid Vehicles' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Within this project a new compact and efficient high speed 30-50 kW electrical machine will be integrated with an efficient fully SiC drive and a gearbox within a powertrain traction module. The electrical machine will have a dry rotor direct liquid cooling system integrated with the cooling system for the SiC drive. This traction module can be mechanically coupled with an axle of a low performance electric/hybrid vehicle, or several units could be coupled directly with the wheels for a high performance vehicle or a light-duty vehicle or a bus. Economic feasibility of mass-manufacturing of different electric machine topologies will be studied to choose the best trade-off between performance, manufacturing cost, and efficiency in the selected performance range. Feasibility of direct drive, single stage, and two-stage switchable high speed gearboxes will be studied as well. The resultant powertrain traction module will be an optimal trade-off between efficiency, manufacturability, and cost, utilizing newest technologies in electrical machines, power electronics, and high speed gearboxes. We will demonstrate the scalability of the solution by embedding several powertrain modules on board a test vehicle.


**Keywords:** distributed drive, high speed motor, SiC inverter, mass manufacturing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimization of joining processes for new automotive metal-composite hybrid parts' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The MetalMorphosis aims to develop a new range of novel metal-composite hybrid products for the automotive industry, based on the knowledge transfer from the Electromagnetic Forming (EMF) usage in joining dissimilar metal products and taking advantage of new developed composites and its capability to be bonded to metal.MetalMorphosis approach is to combine and involve all the main players – Top-down and bottom-up in the value chain – from the automotive industry in the development of the next generation of metal-composites hybrid materials, ensuring a strong contribution from industrial drivers (towards those which are industry’s main needs in what concerns to automotive parts), an active involvement of SMEs (in the manufacturing of pilots / demonstrators), a valuable participation from RTD’s (performing research activities in multidisciplinary key knowledge areas and defining the drive beyond the state-of-the-art) and – last, but not the least – a major role to be played by multipliers organizations who will ensure the exploitation of projects’ main results towards the automotive market and other linked sectors.MetalMorphosis will gather a wide – but simultaneously specialized and multidisciplinary – consortium composed by 9 European partners, according to their expertise areas – Welding and joining technologies, Composites, Industrial Manufacturing and Automotive OEM – which have strong interest in developing new joining processes for metal-composites and lightweight materials addressing the challenges for the automotive industry for the following 10 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The establishment of a world class European apoptosis and anticancer drug discovery capability through transfer of knowledge and integration of assay development, screening and medicinal chemistry' (EAACDD).

assistant: **Concept**

Apoptosis is a highly regulated mechanism used by cells to counterbalance the ongoing process of mitosis. Dys-regulation of this delicate balance is involved in many human diseases, and is central to the genesis and progression of cancer. Advancing the research of apoptosis is of critical importance in the development of novel therapies, with over 1.5 million people dying as a result of cancer in Europe and America each year.While apoptosis holds much promise, the complexity of its biology and lack of translation from bench to clinic has limited its potential thus far. Prof. Tom Cotter, a European leader the apoptosis field, founded EiRx Therapeutics plc. EiRx has established a reputation of cutting edge applied research and has identified circa 200 genes that functionally regulate apoptosis in cancer. To translate these targets to chemical molecules in the clinic would be to unlock the real value from EiRx's research, this requires a world-class Drug Discovery capability.This proposal describes how EiRx will transfer and integrate specialist industrial Drug Discovery knowledge (not currently found in the host country) with its already world-class apoptosis biology, to take its research all the way to the clinic. Specifically, this requires recruiting a very senior Assay Development and Screening Scientist, a Biochemist, and a Medicinal Chemist over a three-year period. By linking biology with chemistry, this multidisciplinary team will significantly advance European apoptosis research and advance new treatments for cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Analysis of new bacillus subtilis genes involved in cell division and sporulation'.

assistant: **Innovation**

Research objectives and content A consortium of Japanese and European labs has recently completed sequencing the genome of Bacillus subtilis-168. Some European labs undertake now a project to systematically inactivate and determine the function of new genes of the sequence. The object of this project would be to contribute to the screening of the mutants showing defects in sporulation and cell division.Then, one or more of the identified mutants of interest would be studied in detail:1. Analysis of the phenotype at the cellular and sub-cellular level, 2. Regulation and expression of the gene, 3. Sub-cellular localization of the protein product, 4. Purification of the protein and investigation of its enzymatic properties and interaction with other proteins.Further development of the project would depend upon the nature of the gene itself and to what extent its study can be integrated with other work ongoing in the lab. Training content (objective, benefit and expected impact) At Oxford, the expertise of the lab ln sporulation, cell division and chromosome partitioning would be used to look specifically for defects in these functions. I would benefit of a wide range of useful methods, especially in molecular genetics, biochemistry and state-of-the-art cytological methods, which are well established in this lab. Links with industry / industrial relevance (22) There is considerable commercial interest in this area at the moment, in relation to development of new antibiotics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Establishing a process and a platform to support standardization for nanotechnologies implementing the STAIR approach' (2007-2013).

assistant: **Concept**

Standardization is one of the most adequate solutions to quickly capitalize and disseminate knowledge in “reference documents”, and have it implemented in the industry. It is very important in the field of nanotechnologies since the production of knowledge is very intensive. The overall objective of nanoSTAIR project is to build a sustainable process and platform in the field of nanotechnologies to support the transfer of knowledge gained through research to documentary standards in the context of the STAIR approach promoted by CEN-CENELEC.The project is organized around several activities that will boost the development of new documentary standards.A mechanism will be set up to identify, with a bottom-up approach, the opportunities for standardization from the results of research projects, co-funded by the European Commission or by National Research Programmes. This mechanism will be established using existing networks and initiatives such as NanoSafetyCluster or NANOfutures, as well as the network of the national standardization bodies in the various Member States.Then, the expression of the needs for standards from various stakeholders will be collected and resources from consortia sharing similar standardization opportunities will be pooled together to launch New Work Items Proposals (NWIP). The nanoSTAIR approach will be verified during the project thanks to 2 NWIP initiated. The consortium will provide assistance to select the right standardization umbrella (Technical Committee and Working Group at CEN or ISO level)As a result, nanoSTAIR will provide a set of procedures, a tool box and a practical guideline that will be useful to bridge the gap between research and standardization in nanotechnologies. nanoSTAIR will structure and ease the development of new docume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Immune-stromal crosstalk in inflammation and fibrosis: Exploiting the spatiotemporal dynamics of the OSM-OSMR axis in inflammatory bowel disease to develop novel antifibrotic therapies' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Intestinal fibrosis is a common and serious complication of inflammatory bowel disease (IBD). While intestinal inflammation can be treated pharmacologically based on our current understanding of the underlying pathogenesis, little is known about the mechanisms driving fibrogenesis. Thus no approved therapies exist for intestinal fibrosis. While stromal cells lie at the heart of fibrogenesis, our knowledge of how immune-derived signals instruct aberrant tissue repair and fibrosis is limited. We recently highlighted that the immune-stromal cell axis is a crucial component of IBD pathogenesis. Our research discovered that the IL-6 family cytokine oncostatin-M (OSM) plays a central role in immune-stromal crosstalk in human IBD, and drives pro-inflammatory responses in patients with refractory disease. Genetic deletion of OSM significantly reduced acute intestinal inflammation. Furthermore, our current findings suggest that OSM is required for intestinal remodeling and the regulation of collagen homeostasis by controlling immune cell recruitment. Thus, the OSM-OSMR axis serves as a rheostat for tissue inflammation and repair. We will investigate how OSM modulates intestinal fibrosis and identify upstream and downstream signaling events controlling intestinal fibrosis. I will use (i) newly generated reporter and conditional knock-out mice, (ii) contemporary mouse models of intestinal inflammation and fibrosis, (iii) primary human tissue samples from carefully clinically annotated IBD patients with intestinal fibrosis, and (iv) cutting-edge technologies including single-cell sequencing and imaging mass cytometry to dissect the crosstalk between the immune system and stromal cells driving intestinal fibrosis. This project will deepen our understanding of the intestinal aberrant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social Economy for Resilience, Inclusion and Good life in Rural areas' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

European rural areas, face societal, demographic, economic and environmental pressures due to global transformations and crises. They are in need of a renewal by social innovation that increases their resilience and reduces the adverse effects on their socio-economic and environmental sustainability. Unbalanced development impacts their populations’ lively-hoods and well-being in general, but it affects the most those people who are already in precarious and fragile positions. SERIGO produces evidence-based theoretical and practicable knowledge on how the Social and Solidarity Economy (SSE) can support resilience, social inclusion, and ‘good life’ in European rural areas. Based on the research results produced, the aim is also to provide insights and recommendations on what framework conditions and policy arrangements are necessary to promote this, as well as to trigger constructive debates and collaborations around this issue involving diverse set of stakeholders in Europe.The project applies an intersectional perspective to vulnerability, as well as implements critical systems thinking in combination with community-based participatory research to investigate potentials of the social economy in promoting social inclusion and in enhancing the quality and accessibility of services in rural areas. Empirical data is gathered in a high number of qualitative case studies from 13 countries on social economy solutions implemented in local contexts. Using the multi-actor approach, SERIGO benefits from more nuanced and ’live’ insights into the drivers of social exclusion offered through the lenses of local stakeholders working together with researchers on co-created experimental pilots in five European regions. SERIGO ensures also with a system of deliberate feedback loops, dedi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'T cell suppression by antioxidant proteins released into the tumour microenvironment' (TS-ATM) targeting Horizon Europe.

assistant: **Abstract**

Oxidative stress promotes genomic instability and oncogenic signaling in cancer, yet antioxidant therapies have largely failed to improve, and in some cases have worsened cancer outcomes. This necessitates a better understanding of how redox dynamics shape not only the biology of cancer cells but their interactions with the host, including the immune system. Reactive oxygen species (ROS) are essential co-factors in T cell activation but whether cancers exploit this vulnerability to suppress T cell immunity and immunotherapy responses is not known. My preliminary data reveal that peroxiredoxin 1 (PRDX1), a potent ROS-scavenging enzyme primarily expressed and released by tumour cells, profoundly inhibit T cell effector function. Genetic deletion of PRDX1 in cancer cells sensitizes otherwise immunotherapy-resistant tumours to checkpoint blockade. I hypothesize that extracellular PRDX1 disrupts redox-sensitive signaling pathways in CD8+ T cells, weakening their cytotoxic capacity and promoting immune evasion of tumours. This hypothesis challenges the prevailing paradigm that antioxidants are inherently beneficial in oncology and instead posits that tumour-derived antioxidants act as immune suppressors. To test my hypothesis, I will pursue three aims: i). Determine whether genetic ablation of PRDX1 in tumours enhances antigen-specific CD8+ T cell responses and improves outcomes following immune checkpoint blockade. ii). Quantify ROS dynamics in T cells across distinct tumour microenvironments and test whether augmenting intracellular ROS levels can overcome T cell suppression. iii). Define the redox-sensitive signaling networks perturbed by PRDX1 and validate key redox signaling mediators in primary human T cells. By uncovering immunomodulatory roles of extracellular antioxi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flavour, unifications and experimental tests' to be submitted under Seventh Framework.

assistant: **Abstract**

The flavour structure of matter remains one of the deepest challenges to our current understanding of the elementary particles and their interactions. Indeed, even after more than half century of intense research the flavour patterns underlying most of the high-energy physics processes defies our comprehension. The Standard Model of particle physics, the best description of the sub-nuclear world ever conceived, does not provide any clues to why we observe just three families of quarks and leptons, what is the origin of the peculiar pattern of their quantum-mechanical mixing or why their masses range over more than twelve orders of magnitude. With the advent of the next generation of particle physics experiments, in particular the Large Hadron Collider, the high-precision neutrino facilities, large-volume rare decay searches and other kinds of instruments and techniques focusing on uncovering physics beyond the Standard Model, there is a growing and well-founded expectation that the next decade could witness the first glimpse on these mysteries. The current proposal addresses these fundamental problems from the perspective of Grand Unification, one of the best motivated hypotheses about the nature of the fundamental dynamics governing the very birth of the Universe. A thorough understanding of the elusive low-energy imprints of physics at very high energies provides a unique strategy for testing the unification paradigm, complementing the traditional techniques of its experimental scrutiny. Apart from unwinding further the conundrum of the perennial problem of flavour, the proposed programme stresses the interdisciplinarity, covering topics from astroparticle physics and cosmology up to the experimental signatures and collider phenomenology. In this respect, it has a ver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Innate behavioral modulations across different life stages'.

assistant: **Innovation**

The balance of risk-taking and avoidance is essential for survival. Across different stages of life an animal’s priorities shift, which is reflected in changing behavioral preferences both during adolescents, when typically more risks are taken to facilitate exploration, and parenting, when avoiding risk is prioritized to ensure the safety of their young. These behavioral changes are correlated with distinct changes in hormonal levels. In mice, recently weaned adolescents exhibit high levels of corticosterone while parenting mice have increased oxytocin. The principles of how these changing hormonal levels impact the processing of information in neural circuits is poorly understood. Visually evoked avoidance behaviors are triggered through circuits of the superior colliculus. Here I will uncover how changing hormonal levels act to influence the processing of visual stimuli arriving from the retina and the resulting behaviors (e.g. freezing or escape). I will determine how this circuitry is affected by hormonal changes occurring across different life stages and whether these changes explain the resulting changes in behavior. To accomplish this, I will measure changes in innate defensive behaviors at different life stages, then identify the underlying circuit mechanisms involved. My expertise in precise circuit dissection in the retina provides me with the ideal background to uncover the mechanisms underlying the hormonal modulation of circuits in the superior colliculus. Recent technological advancement in functional imaging and large-scale electrophysiology along with new understandings of cell types and pathways of the superior colliculus provide the appropriate opportunity to identify the local and global modulations of visual processing driving hormone dependent chan