RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Designing web-based learning environments to support middle school students' reflective inquiry of complex scientific problems' under Sixth Framework.

assistant: **Concept**

The purpose of this research is to investigate the role of new technologies in supporting middle-school students' reflective inquiry practices in science. Specifically, the work concerns the design of an inquiry-based learning environment on the WWW and the examination of the role of learning scaffolds in encouraging students' meta-cognitive reasoning with scientific data. The ability to reason with scientific data is extremely important in today's society. Inquiry is seen as a way to enculturate students into the world of science, by engaging them in activities that resemble authentic scientific practices. However, we know that students need to be meta-cognitively supported in order to engage in inquiry.The proposed work will use prior research to design a web-based learning environment to support students' reflective inquiry, consisting of two parts: the first, will be a web-based inquiry investigation of authentic scientific data. The second will be a reflective workspace, where students can organize snapshots of the data to use as evidence. Students will also be encouraged to respond to articulation prompts embedded in the web pages, asking them to consider the relationship between the data and their hypotheses and guiding them in constructing detail ed explanations. We will assess the role of new technologies in supporting the construction of evidence-based explanations, collecting and analysing qualitative and quantitative data from three classes of students, working in authentic classroom environments under the following conditions: a) web-based inquiry with reflective supports; b) inquiry investigation with paper-based reflective supports; c) inquiry investigation with no reflective support.It is hoped that with the support of this MC IRG, the researcher will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Processing of oxidatively induced clustered DNA lesions under a double strand break repair deficiency in human tumor cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Although a number of risk factors associated with cancer have been well established for many years, there is an emerging need for delineation of the role of DNA repair factors relative to cancer risk, and especially the discovery and quantification of risks associated with gene mutations in double strand break (DSB) repair factors (e.g. BRCA1, DNA-PK, Lig4, XRCC4).  In addition, higher levels of oxidative stress (reactive oxygen species, ROS), DNA damage and/or defective DNA repair have been reported in different malignancies and tumors. The long term objective of this project is to identify the role(s) of BRCA1 (homologous recombination-HR) and DNA-PK (non-homologous end joining-NHEJ) two key double strand break repair (DSBR) proteins in the processing of non-DSB oxidatively induced single and clustered DNA lesions (OCDLs) in human gamma-irradiated tumor cells. In addition, chromosomal instability and apoptosis will be measured in each case. There are very limited and only fragmentary data on this specific field. Based also on preliminary data, our central hypothesis is that a compromised DSB repair pathway will also lead to deficient OCDL repair and accumulation of oxidatively-generated DNA lesions when DSBR deficient cells are challenged by various oxidizing agents like ionizing radiation.  These studies are expected to provide meaningful mechanistic insights into DNA repair pathways involved in the processing of non-DSB clusters and therefore advance the field. They will also contribute to cancer etiology associated with complex DNA damage since accumulation of OCDLs is associated with increased mutation rate and chromosomal instability. Fingerprinting the molecular identity of these DNA modifications can be utilized in designing more efficient cancer therapeutic st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Zambezian Entanglements in the South Central African Iron Age' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

ZAMBEZI introduces a radical new precolonial history of an African region in the Middle Zambezi Valley. The project explores the site of Ingombe Ilede in Zambia and its regional setting, using a nested methodology offering three levels of innovation: (1) deep understanding of a crucial but under-explored site; (2) pioneering methodologies offering unique detail on human settlement and mobility; and (3) a transformative view of the African past derived from an exploration of diversity and contingency.Rescue excavations at Ingombe Ilede in 1960 captured attention due to the discovery of rich burials suggesting the existence of a wealthy elite; the materials illuminate resource networks from the Copperbelt to the eastern African coast. The richest period was contemporary with 15th/16th century Portuguese colonial intrusion, and thus Ingombe Ilede has a story to tell that encompasses the socio-economic landscape of the precolonial Zambezi, as well as the emergence of a local elite during a moment of global encounter.Building on the expertise of the PI in constructing human-scale archaeological histories through combined methods, the project will apply an ambitious methodology combining established techniques and new technologies to create detailed life histories and diachronic understandings of settlement and society. The project will produce a microhistory with the capacity to transform our understanding of macro-histories of this region, highlighting emergent cultural forms that stem from mobility and encounter. Detailed, human-level stories about African societies are urgently needed, as the building blocks of our explorations of the global past. ZAMBEZI offers a unique opportunity to tell a new story about the African past, beyond narratives of migration or the emergenc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation of DNA interstrand crosslink repair by ubiquitin.' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of this proposal is to understand, on an atomic level, the mechanism of activation and regulation of the Fanconi Anemia (FA) DNA repair pathway. Homozygous mutations in the FA pathway lead to Fanconi Anemia, a devastating childhood genome instability disorder, typified by bone marrow failure and a high predisposition to cancers. The FA pathway is required for the repair of DNA interstrand crosslinks (ICLs), the hallmark of many cancers and FA. ICL repair is poorly understood on a biophysical and mechanistic level. The FA pathway is regulated by ubiquitin, in a cycle of monoubiquitination and deubiquitination of FANCD2. Despite considerable advances in our understanding of the genetics of the pathway, there is strikingly little known on a mechanistic and chemical level concerning how the ubiquitin signal is assembled, recognised and disassembled. We will define, on an atomic level, the site-specific monoubiquitination and deubiquitination cycle of FANCD2 in its entirety. We will determine the mechanism of FANCD2 monoubiquitination, identify and characterise currently unknown readers of the monoubiquitin signal, define the role of the core complex in the modification of FANCD2, and the requirements for removal of the signal. To tackle this ambitious work we will determine the atomic level three-dimensional structure of key complexes in the modification cycle, and develop a novel method for producing large quantities of stably modified FANCD2. The results of our work will represent a major breakthrough in our knowledge and understanding of the regulation of a critical DNA repair process, will provide a model for understanding mechanisms of monoubiquitination, and will open up both therapeutic potential and new pathways for research into the cause and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'History and Philosophy in Science Teaching'.

assistant: **Innovation**

In order to develop a better integration of science in society and society in science the promotion of young people’s interest in science, to encourage their critical and creative ways of thinking and to improve science education, and the uptake of scientific careers in general is of vital importance. Sustained learning of science implies many different dimensions. One often ignored, but important dimension is the way how scientific knowledge is gener-ated. Moreover the objectives and motivations to do science, scientific methods, the em-pirical fundament, social and cultural aspects are as important as philosophical founda-tions of science, scientific concepts and their use. The acquisition of knowledge about the nature of science is essential for democratic societies which partly rest their decision-making on rational and scientific criteria. The HIPST project works with 10 partners from 8 countries covering R&D, policy and implementation aspects of the acknowledgement. HIPST aims at the raising of understanding the relationship between science, technology, and society, and to foster science education and public understanding of science on a European level. The project approach has three specific objectives: To increase the inclusion of history and philosophy of science in science teaching for the benefit of scientific literacy. To improve strategies for development and implementation of domain-relevant materials and teaching techniques into educational practice. To strengthen the cooperation and establish a permanent infrastructure of sustainable network-ing of all involved stakeholders in the field of scientific literacy and public understanding of science (school science teachers, museum experts, researchers). HIPST establishes a sustainable network between the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Implementation of true orderings' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Our purpose is to study a class of problems where society wants to elicit the truth from the agents. Think on the problem of wine testing, gymnastic competition, or a group of students applying for a scholarship. All these situations have a common structure. There is a fact that occurs (a specific ranking of the alternatives that we will call the truth) and that it is observed by the people who decide the final outcome (members of a jury). This fact determine the preferences of the deciders over the alternatives. However, the preferences of each jury member may also depend on some external facts (for example. each decider may have a most (least) preferred alternative, and so he prefers this alternative as high (low) as possible in the final ranking, whatever the true is). The deciders send messages (score points, orderings, etc). These messages are translated, by means of an outcome function, in a final ranking. The messages together with the outcome function is what we call a mechanism. Our aim is to look for such successful mechanisms Training content (objective, benefit and expected impact) The question whether the truth can be implemented even if deciders have incentives to behave strategically is essential since in general, the members of the jury have friends and/or enemies among the set of alternatives that have to be ordered. The variety of situations in which the former model makes sense is enormous: From the problem of a group of scientists dividing a price,to gymnastics competitions. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'FaciLitating Access to Socio-economic ResearcH through Information and Communications Technology'.

assistant: **Innovation**

The general objective  of the project is to contribute to increased dissemination and exploitation of the SSH projects research findings. The project, taking also advantage of new ICT-based technologies and tools, will :Provide consolidated information arising from FP6 & FP7 SSH research projects and activities addressing major societal challenges on issues close to the main political priorities of the EU identified in the new Europe 2020 strategy: 1. Innovation Union (including economic and social innovation, social cohesion and demographic changes); 2. Youth, 3. Employment, 4. Poverty; Develop effective communication tools (such as Policy Snapshots, Policy Research Alerts, Multi-stakeholder policy dialogue workshops,  interactive and innovative web platform), engaging all relevant SSH players such as European, national and local decision-makers and multipliers (policy-makers, journalists, academics, industry, civil society organisations); Improve access to research data as results of SSH projects focusing on common rules and frameworks to be applied in data management, exploring the possibilities of ex-ante and ex-post coordination with FP funded projects. Expected outputs: Evaluation of the opportunities offered by new forms of ICT for networking and clustering ongoing SSH research projects and enable exchange and knowledge transfer between projects/clusters of projects; Assessment and collection of best practices among SSH research projects in exploiting ICT technologies for knowledge transfer and dissemination of results & key messages targeting different stakeholders; Dissemination of relevant SSH projects results through effective communication tools; Analysis of the state of the art related to the usage of Open Access pilot to identify data standards to be appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial contribution to continental wetland carbon budget', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Continental wetlands are major carbon dioxide sinks but the second largest source of methane. Monitoring of wetland methane emissions revealed large inter-site variability that is hard to explain in the framework of current biogeochemical theories. Methane production in wetlands is an anaerobic microbial driven process involving a complex set of microbial metabolisms depending on the availability of (i) energy (via the presence of specific redox couples), (ii) organic substrates and (iii) specific microbial communities. To understand the complexity of microbial drivers on wetland methane emissions and quantify their contribution, the MICADO project will set up a multidisciplinary approach linking isotope organic geochemistry and environmental microbiology to assess microbial functioning in situ. As an organic geochemist I have developed an innovative approach to trace in situ microbial activity via compound specific carbon isotope analysis of microbe macromolecules and organic metabolites. The host institution is a leader in France in environmental microbiology and biogeochemistry developing high-throughput metagenomics and microbial rate assessments, for which I will be trained during the MICADO project. These techniques are highly complementary and combined they will provide a comprehensive knowledge on microbial metabolisms involved in organic matter degradation encompassing their complexity and interactions. This will revisit the relationships between organic substrate availability and microbial communities and will contribute at estimating the impact of microbial activity on wetland methane emissions. This project will give me the opportunity to acquire fundamental knowledge and to develop original lines of research that will consolidate my position as an independe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MetamorphoSis of cultural Heritage Into augmented hypermedia assets For enhanced accessibiliTy and inclusion' (SHIFT).

assistant: **Concept**

SHIFT is strategically conceived to deliver a set of loosely coupled, technological tools, that offers cultural heritage institutions the necessary impetus to stimulate growth, and embrace the latest innovations in artificial intelligence, machine learning, multi-modal data processing, digital content transformation methodologies, semantic representation, linguistic analysis of historical records, and the use of haptics interfaces to effectively and efficiently communicate new experiences to all citizens (including people with disabilities). The development of SHIFT tools will be carried out in close consultation with the stakeholder communities represented in the project. The two CH networks (BMN, ANBPR) will launch open consultation to aggregate views from their members, while together with the cultural heritage institutions (SOMKL, SMB) and heritage professionals (Heritage Management), will provide requirements based on the cultural assets being maintained within each organisation. The diversity of digital media transformation and the semantic formalisation of the cultural assets will be individually demonstrated across each museum and library. Additionally, the inclusion by design principles adopted within the project, will be evaluated by CH networks and vulnerable group partner (DBSV), who will engage with the various tools developed in the project. In complementary to the stakeholders and end-users, the SHIFT project also brings together leading industrial (SIMAVI) and academic institutions (FORTH, UAU, QMUL). The consortium is complemented by SMEs (MDS, AUD) with high-tech product development teams and ethical expertise (ERC). Collectively, the project will release 12 technology solutions clustered into five thematic areas (computer vision, audio, text-to-speech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The impact of SA signaling in CWI impairment and downstream factors' in the context of a Horizon Europe call.

assistant: **Objectives**

The plant cell wall (CW) is a crucial defense layer surrounding plants cells. CW composition and structure are directly associated with environmental stresses and biomass production. Cell Wall Integrity (CWI) maintenance is a crucial key player responsible for monitoring and maintaining plant CW composition and structure under biotic and abiotic stresses. Thus, the new knowledge and understanding of the CWI machinery have enormous potential to increase crop production and develop new highly adaptive crop species. The CWI maintenance mechanism involves receptor-like kinases and ion channels in the plasma membrane, which perceive signals arising from CWI impairment and modulate downstream signaling cascades, leading to changes in cytoskeleton organization, phytohormone production (ABA, SA, JA, and ethylene), gene expression, and cell wall composition/structure. I will use my expertise in signaling transduction pathways and combine them with the knowledge and skill used host lab on CWI signaling pathways to determine the mechanism regulating SA responses and downstream factors of plant cells in CWI impairments. Therefore, my project aims to discover transcriptional regulators mediating the response to impairment of primary cell wall integrity and characterize signal transduction elements controlling SA induction and modulating SA-controlled responses. I will share the results with the scientific community and the public using social networks, attending international conferences, and publish research outcomes in a high-impact scientific journal in an open-access format. This project will form the foundation of my future career as a researcher, and the project results can be used to increase crop production and develop new highly adaptive crop species.


**Keywords:** salicy