RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Leukemia animal models' (1998-2002).

assistant: **Innovation**

New therapeutic approaches specifically target the molecular interactions and biochemical pathways that are changed in tumor cells. Animal models that either express human oncoproteins, or harbour human malignant cells are currently showing to be a great promise in providing a novel tool to study in situ" hematopoiesis and leukemogenesis. The three workshops proposed will schematically concern, Animal Model Technology in Preleukemia (November 1999), Lymphoid disorders (November 2000) Myeloid disorders (November 2001). The presence of multidisciplinary groups will allow to define the hematopoietic disorders that raise a significant therapeutic goal to society (suggested by the clinicians in terms of frequency and/or lack of effective therapy) and for which significant biological markers are well known.Keynote speakers will summarize insights in what is already known and what have been the findings and the problems. Technologies will be exchanged, discussed, improved and shared. Audience expertise will be incorporated in the discussions and in the subgroups. Indeed experienced researchers, clinicians and students as well as Biotechnology engineers or companies will discuss with the specialists the pros and cons of the presented data. These last interactive groups will allow defining strategies to standardize, exchange knowledge and material, provide training session etc.Our concluding sessions will spotlight exciting new sensor technology and state-of-the-art tools. The workshop will take place at the Hospital Saint-Louis, in the North of Paris. This site is conveniently located not far major transportation. The first meeting on animal was held in Paris in November 1998 and the second meeting in the USA in January 1999. 80% of the participants of the meeting in Paris were
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AI Enabled Managemement of Patients at Risk of Diabetic Foot Ulcer' (DELTA) targeting Horizon 2020.

assistant: **Abstract**

Diabetic foot ulcers (DFU) lead to approximately 150,000 amputations and €23 billion in costs in Europe each year. Of the60 million diabetics in Europe , 1.5 million currently have a diabetic foot ulcer and 15 million will develop on at some point intheir life . Each ulcer takes 3-6 months to heal and costs upwards of €14,000 to treat, however, if hospitalisation oramputation is required these costs can be as high as €100,000 . Diabetic foot ulcers pose a significant burden on healthcaresystems around the world. The NHS in England spends almost 1% of its entire annual budget (£1.13 billion) on the diabeticfoot. Almost all of these ulcers and amputations are preventable through early identification and proper care. BluedropMedical are developing a remote monitoring system that uses computer vision and machine learning to predict and preventdiabetic foot ulcers (DFUs). The home-based device, taking the form of a bathroom scales, performs a daily scan of thepatient’s feet. In 10 seconds, thermal and photographic data is collected and sent to the cloud. Advanced algorithms monitordaily foot scans to detect DFUs before they develop, providing actionable alerts to both patient and healthcare provider. Thetechnique of temperature monitoring has been proven to prevent 70% of DFUs and Bluedrop Medical are building thistechnique into an easy and quick to use device enabled by advanced sensor technology, computer vision algorithms andmachine learning. By preventing ulcers, the technology can prevent hundreds of thousands of amputations, improving livesand saving healthcare systems millions of euro each year. Bluedrop Medical is targeting the highest risk patients whocurrently have a 30-40% annual incidence of ulceration by preventing ulcers in this group a potential average saving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Discovering novel control strategies for turbulent wings through deep reinforcement learning'.

assistant: **Innovation**

Over the past decades, aviation has become an essential component of today’s globalized world: before the current pandemic of coronavirus disease 2019 (COVID-19), over 100,000 flights took off everyday worldwide, and a number of studies indicate that after the pandemic its relevance in the transportation mix will be similar to that before COVID-19. Aviation alone is responsible for 12% of the carbon dioxide emissions from the whole transportation sector, and for 3% of the total CO2 emissions in the world. Due to the major environmental and economical impacts associated to aviation, there is a pressing need for improving the aerodynamic performance of airplane wings to reduce fuel consumption and emissions. This implies reducing the force parallel to the incoming flow, i.e. the drag, and one of the strategies to achieve such a reduction is to perform flow control. DEEPCONTROL aims at using high-fidelity simulations and deep reinforcement learning to develop a framework for real-time prediction and control of the flow around wing sections and three-dimensional wings based only on sparse measurements. We will first perform high-order spectral-element simulations of wing sections and three-dimensional wings at high Reynolds numbers. Using sparse measurements at the wall, we will reconstruct the velocity fluctuations above the wall within a region of interest. To this end, we will employ a generative adversarial network (GAN), together with a fully-convolutional network (FCN) and modal decomposition. Then, we will perform flow control based on deep reinforcement learning (DRL), which will enable discovering novel solutions in terms of flow actuation and design of winglet geometry. In order to assess the robustness of the framework for real-time applications, we will carry ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Capturing transition states associated with lineage decisions in the early mouse embryo' in the context of a Seventh Framework call.

assistant: **Objectives**

During early mouse embryogenesis the cells of the blastocyst’s inner cell mass take a lineage decision to contribute either to the epiblast or the primitive endoderm (PE). The allocation of cells to either lineage depends on the activity of FGF signaling and two gene regulatory networks (GRNs), one centered on the transcription factor Nanog, the other one relying on Gata factors. The two GRNs are initially activated in an overlapping and heterogeneous pattern in the ICM, and have been proposed to compete each other out over time. The dynamics of this competition, and how the transition state between the two lineages, marked by co-expression Gatas and Nanog, is resolved, is not known.Here I propose to address these questions in vitro by recapitulating the competition between the Gata- and Nanog-GRNs through the controlled overexpression of Gata factors. This converts embryonic stem cells (ESCs), which contribute primarily to the epiblast when introduced in chimeras, into extraembryonic endoderm (XEN) cells, which contribute solely to PE derivatives. I will combine fluorescent reporters with this ES-to-XEN transition to ask with which dynamics transitions occur in individual cells, whether they involve heterogeneities at the population level, and how these parameters are controlled by the activity of gene regulatory networks and signaling pathways. I will aim at identifying culture conditions that stabilize the transition state, where cells might be on the brink of being XEN, and therefore akin to ICM. I hypothesize, that under these conditions cells will be endowed with higher developmental potential compared to parental ES cells, and be able to contribute to both epiblast and PE-derived tissues.The results of this project will enhance our understanding of the mechanisms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EcoWeb a dynamic e-dissemination platform for EU eco-innovation research results' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Europe has a leading position in eco-innovation patents and emerging technologies. Although the EU achieves a remarkably high annual growth rate of 16% in eco-innovation, transfer to SMEs is rather low. Technology transfer to SMEs would be important to reduce EU’s industrial pollution. According to OECD and EC reports, awareness for RTD results is low. There is a need to increase technology transfer at the EU level.A common platform at the European level will speed up promotion and transfer of existing technologies. The platform will focus on Framework Programmes results and other EC funding initiatives.In the proposed project, it will be developed a dynamic platform (EcoWeb) for enterprises, especially SMEs, to take up eco-innovation results from EU funded research. This will increase uptake of novel technologies, spur economic growth, and will result in an increase of SME interest in the FP.EcoWeb will bring companies close to relevant eco-innovation EU results through semantic-web-technology and existing eco-innovation networks and multipliers. Based on semantic-web-technology EcoWeb will collect and structure information whilst multipliers will disseminate results through existing channels. In particular EcoWeb will achieve:• collect and structure RTD results on eco-innovation;• match innovations to the technical needs of the SMEs.• bring innovations to SMEs instead of having the SMEs looking for them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cartilage derived from equine induced pluripotent stem cells: an in vitro and ex vivo One Medicine approach for osteoarthritis' (CAREQiPSC).

assistant: **Innovation**

Osteoarthritis is a degenerative joint pathology that constitutes the first cause of disability in older adults and accounts for >80% of chronic lameness in horses. Effective treatments are not available while developing them is of utmost importance for the EU objective of translating knowledge into society’s benefit. Induced pluripotent stem cells (iPSCs) can provide unlimited cells for therapy with no ethical concerns. However, pre-clinical knowledge is limited to small animals with low translational potential. Larger species such as the horse better resembles human joint’s features and can also benefit from these therapies (One Medicine). To develop this approach, the first mandatory step is obtaining suitable cartilage from eqiPSCs. Thus, the goals of CAREQiPSC are: 1) establishing eqiPSCs from new sources with potential chondrogenic commitment, 2) derive mesenchymal-like cells with chondrogenic potential, 3) compare their chondrogenic ability under different conditions, 4) explore their therapeutic potential in an ex vivo cartilage explant system. To achieve these goals, eqiPSCs will be established from articular chondrocytes, umbilical cord mononuclear cells, and dermal fibroblasts, and their pluripotency will be studied. Mesenchymal cells derived from these lines will be characterised and induced to differentiate in the customary pellet system and in a 3D scaffold. The tissue obtained will be studied by histology, protein and gene expression, and its therapeutic potential will be investigated in cartilage explants, also including imaging and biomechanical assessment. The researcher’s previous experience in the equine model and the host’s expertise in iPSCs and infrastructure will ensure the achievement of these goals. The main outcome will be critical in vitro an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Digital Technologies ActiNg as a Gatekeeper to information and data flOws' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

TANGO will establish a stronger cross-sector data sharing, in a citizen-centric, secure and trustworthy manner, by developing innovative solutions while addressing environmental degradation and climate change challenges. The overall outcome is a novel platform exhibiting the following capabilities: user-friendly, secure, trustworthy, compliant, fair, transparent, accountable and environmentally sustainable data management, having at its core technology components for distributed, privacy preserving and environmentally sustainable data collection, processing, analysis, sharing and storage. This platform will promote trustworthy and digitally enabled interactions across society, for people as well as for businesses. TANGO will leverage the power of emerging digital technologies to strengthen the privacy for citizens and private/public organisations, reduce costs and improve productivity. It will unlock the innovation potential of digital technologies for decentralised, privacy-preserving applications, while making accessible and demonstrating this potential within the GAIA-X and EOSC ecosystem. With 37 key partners from 13 countries, TANGO, is uniquely positioned to provide a high impact solution within the transport, e-commerce, finance, public administration, tourism and industrial domains supporting numerous beneficiaries across Europe.Through the provision of TANGO technologies, a trustworthy environment will be designed acting as a gatekeeper to information and data flows. Citizens and public/private organisations will be empowered to act and interact providing data both online and offline. TANGO will focus its activities on 3 main pillars: (i) the deployment of trustworthy, accountable and privacy-preserving data-sharing technologies and platforms; (ii) the creation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Harmonisation of Fire Resistance Testing: Thermal Aspects', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

By experience it is known that fire resistance furnaces yield deviating results on identical specimens although controlled within current standards. This is the main remaining problem for achieving harmonised fire resistance testing of building products in the EU.In this project, the technical aspects of the above problem will be quantified and, where possible, solutions will be offered. The specific objectives are to:investigate the extent to which applying Plate Thermometers to monitor furnace temperature will solve problems of reproducibility;redesign and evaluate the calibration elements used in previous work;investigate the reasons why differences in the thermal environment of the furnace have a large effect on the temperature observed at the unexposed side of a separating element.The initial development work is in progress and the testing phase is expected to begin in November 1997.Initial work will be carried out to:redesign the calibration element for tests on building components with a separating function;design a calibration element for tests on building elements totally engulfed by fire; investigate the role of furnace construction parameters using a mathematical model of the heat exchange in the furnace; design a simple, passive heat flux meter and an active heat flux meter for the non-exposed side of test specimens.Subsequently, 24 resistance to fire tests will be carried out on well defined test specimens with furnace control by the Plate Thermometer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ENVIRONMENTAL ADAPTATION OF THE GENOME: A DAPHNIA MODEL UNDER CULTURAL EUTROPHIATION' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Organisms, including man, play an important role in ecosystem processes. However, little work has examined how man-made environmental changes affect the way organisms evolve and adapt to modified ecosystems. Our aim is to explore the evolutionary mechanisms involved in local adaptation of species to anthropogenic environmental changes. The project will assess how cultural eutrophication (i.e. nutrient enrichment of freshwater systems) influences evolutionary changes in organisms using a multidisciplinary approach involving population genetics, genomics, and palaeo-genetics. The applicant will focus on genes from pathways involved in the handling of phosphorous (P) in natural populations. The model chosen is the waterflea, Daphnia pulex. The applicant expects to find changes in the genotypic composition and physiological mechanisms both over time (between populations resurrected from dormant egg banks at different dated layers in sediment cores) and over space (between extant populations inhabiting lakes that differ in eutrophication history). The main objectives are: 1) Characterize neutral genotypes and those under selection from cores and extant populations within each lake; and 2) Find natural genotypes differentially-adapted to low and high carbon (C):P levels, via genomic (transcriptome) tracking. This multidisciplinary approach represents an original way to tackle problems of great evolutionary, ecological, and economical importance. Particularly, cultural eutrophication is a major ecological concern of increasing importance due to the direct implications for humans. This IOF proposal will involve two high quality institutions, Univ. of Oklahoma (UO) and Spanish Council for Scientific Research (CSIC). Other international collaborations with the UO Biological Stati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Engineering CAR-T cells to overcome glycosylation-driven tumour resistance', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

T cells engineered to express tumour-specific chimeric antigen receptors (CAR) proved effective against B-cell tumours. However, as the technology moves to solid cancers, clinical responses have not been as robust. In this setting, several barriers need to be overcome, including poor tumour recognition and a highly immunosuppressive tumour microenvironment (TME). Altered glycosylation is a hallmark of cancer, often manifesting as incomplete synthesis of O-glycans and increased branching of N-glycans. Glycosylation can mask epitopes to antibodies recognition and suppress anticancer immunity. My Unit was the first to report that N-glycans protect tumours from CAR-T cells and that pharmacological inhibition of N-glycosylation improves efficacy of CAR-T cell therapy in solid malignancies. With the aim of generating a single cell product able to safely offset multiple barriers of tumour resistance, I propose to engineer CAR-T cells to locally express an enzyme able to de-glycosylate tumour and TME cells. This goal will be achieved through the selection of a mutant able to deglycosylate the surface proteome of target cells. To regulate its function in CAR-T cells, I plan to test different systems based on the use of specific promoters, the inclusion of artificial miRNA target sequences, or the generation of a transmembrane variant. A deep characterization of the selected product will be performed in mice reconstituted with a human haemopoietic system. This model will allow to study the efficacy and safety of the proposed approach, and to assess its ability to remodel the TME toward a pro-inflammatory state. I believe that this project will have an immediate impact on cancer immunotherapy, will fuel the development of antiviral approaches and will provide new technological pla