RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The incretin system: From genetic determinants to impact on early development of type 2 diabetes in the population'.

assistant: **Objectives**

The incretin hormones (GLP-1 and GIP) are secreted from the gut in response to food intake and their primary role is to amplify nutrient-induced insulin release. Most of this effect is lost in obesity and type 2 diabetes. Glucagon acts as a counter-regulatory hormone to insulin and may therefore also be essential in type 2 diabetes pathophysiology. My objective is to carry out a unique combination of state-of-the-art phenotyping and genotyping in a large, well-characterized cohort of people at key stages of increased diabetes risk. I will genotype a large panel of more than 500,000 genetic markers in 2,082 individuals with varying levels of glucose tolerance, either normal glucose tolerance, impaired fasting glycaemia, impaired glucose tolerance or type 2 diabetes. In addition, I will measure plasma levels of GLP-1, GIP and glucagon at 0, 30 and 120 minutes during an oral glucose tolerance test in the same individuals. I will then examine the effect of these genetic markers on incretin and glucagon levels during the oral glucose challenge. The results of the association study will be followed up in an additional cohort consisting of ~8,200 individuals from Sweden and Finland. The knowledge generated about the complex interplay of mechanisms driving the earliest stages of diabetes will allow identification of new potential targets for individualized prevention and treatment of type 2 diabetes. The epidemiological scale of the study will enable a direct translation of the findings to the real-life setting of population-wide general practice-based diabetes screening and tailored prevention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Access to the central laser facility at the rutherford appleton laboratory' to be submitted under Fifth Framework.

assistant: **Abstract**

Description:The Central Laser Facility operates one of Europe's premier laser laboratories for research in pure and applied science including laser-plasma interaction physics, photo-chemistry and biology. Facilities include Astra, the ultra-short pulse, high power (>10TW) high repetition-rate laser, a dual-wavelength tuneable (UV to far IR) OPA system for ultrafast studies which specialises in psec time-resolved vibrational spectroscopy (Raman and IR), a 110psec resolution confocal microscope and an 80Hz laser plasma soft X-ray source. Ancillary facilities include experiment set-up, film analysis, physical, chemical and biological specimen preparation and computing.The minimum amount of access offered to EU researchers for the full duration ofthe IHP contract is 24 weeks of the Astra facility, ultra-fast tuneable lasers and the X-ray source.Application:a) Calls for proposals for potential users are published in New Scientist and on the CLF Web pages;b) The Chairman of the Users Selection Panel is Prof. CLS Lewis, Queens University, Belfast, UK;c) The primary consideration of the Users Selection Panel in the scientific peer review of proposals is the scientific excellence of the proposal.This judgement takes into account issues of timeliness, feasibility of the project with the facility and the resources available and assessing the likelihood of successful publication of results at the highest level. Priority is also given to research teams who have not previously used the facility.Project Manager:Mr CN Danson, Central Laser Facility, CLRC Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX, UKTel: +44-1235-446340Fax: +44-1235-445888E-mail: c.danson@rl.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of pax-6 in the development of the cerebral cortex' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content Pax-6 gene is responsible for the small eye (Sey) mouse mutation. Previous studies suggest cortex malformations in the developing brain of Sey/Sey mice. The aim of the project is to investigate the mechanism which is disrupted during cortical neurogenesis in the Sey mouse. I will try to study in vitro the migration of neural cells in cortical development by developing an organ culture system using brain slices from mouse embryos. With this approach, the analysis of neurogenesis may be extended to stages several days after birth and we will be able to follow the fate of neurons in Sey mice. The process of cell migration can be followed directly over time by labelling cells using a marker gene which when expressed is non toxic and detectable in living cells. I will use two reporter genes, the gene encoding the jellyfish green fluorescent protein (GFP) and the bacterial LacZ gene. I will use lipophilic dyes, viral and retroviral vectors to label cells. The premigratory cells of the ventricular zone are a population susceptible to retroviral infection and I will use retroviral vectors to infect these proliferating cells. In addition adenovirus vectors will be use to infect not only mitotic but also postmitotic cells, labelling cells in any part of the brain. Training content (objective, benefit and expected impact) This methodology will permit examination of the migration pattern of neuronal cells of Sey/Sey as compared to wildtype cells. The proposal try to answer some fundamental questions about the migratory route of affected neurons and the role that Pax-6 has in this deffects. In addition the proposed proyect will give me the opportunity to adquired experience in many embryological techniques required in the analysis of development and b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Addressing malnutrition and metabolic health in non-communicable diseases through precision Nutrition: impact in quality of life and prognosis of lung cancer patients.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Malnutrition represents a major burden for a large part of the population and, in particular, for vulnerable population groups like lung cancer patients. Lung cancer is a global health crisis, with over 2.2 million new cases in 2020 and profound societal and economic impacts. Lung cancer patients suffer from reduced quality of life, psychological distress, comorbidities, and the challenges of frequent treatments, as well as malnutrition and metabolic complications.MENTORING seeks to enhance patients' nutritional and metabolic statuses by targeting deficiencies in macro- and micronutrients and restoring the microbiome and glycomic health profiles. This will contribute to improving the overall quality of life of lung cancer patients, increasing treatment efficacy, and potentially enhancing their survival rates. By combining dietary assessment, nutritional and clinical biomarkers, immune-inflammatory signatures, anthropometry, genetics, glycomics, lung and gut microbiome, and food-related metabolomics, we will develop holistic models able to predict individual responses to personalised dietary plans considering multiple nutritional and metabolic outcomes. This precision nutrition approach will play a critical role in lung cancer care by customising dietary guidance based on an individual's genetic makeup, nutritional assessment, and health status to reduce cancer progression and increase quality of life.This collaborative effort is tailored to the specific needs of Lung cancer patients, but it has been built in order to make it easily translatable to any other vulnerable population suffering from malnutrition or metabolic impairments. The ultimate goal of MENTORING is to enhance patients' nutritional and metabolic statuses by using validated multi-omics approaches, potenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Room to manoeuvre: gender and coping strategies in the fisheries sector' (GENDER).

assistant: **Concept**

The principle objective of this accompanying measure (AM) is to identify research orientations which contribute to the sustainable development of natural resources. This AM is concerned with a gendered perspective of change and adaptability in fishing communities in coastal West Africa. Taking a livelihoods approach, research will examine how, in a context of increase globalisation, economic reforms and environmental degradation, communities as a whole adapt to change and how gender relations within those communities evolve to absorb the shocks and stresses placed upon their livelihoods. The main activity of the AM is a workshop in Benin.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Estuarine specific transport and biogeochemically linked interactions for selected heavy metals and radionuclides'.

assistant: **Objectives**

Previous work in Arctic marine and Siberian reverie systems has provided science with some of the tools necessary to model the transport of contaminants from inland sources to the open sea. The picture, however, is incomplete because unimportant link in the system, i.e. the marine-freshwater interface, has received little attention in the past. This project aims to redress this balance with the main objective of modelling the biogeochemical behaviour and impact (man and environment) of selected radio nuclides and heavy metals in the Hennessey Estuary. This will be achieved primarily through (a) collation of data relevant to marine modelling; (b) field studies for the purpose of model parameterisation and the identification of biogeochemical reactions; (c) development of new and existing transport models. The result will be a set of tools which can be used to determine the behaviour and fate of selected contaminants in a large Siberian estuary.The project has been largely successful in addressing project objectives. All deliverable reports have been completed and submitted to the EU. Progress has been made within several scientific areas. Three successful field expeditions were held during the project duration. This includes work on board the R/V Akademik Boris Petrov in the summers of 2000 and 2001 and additional terrestrial field campaigns conducted on areas affected by ocean land interactions in 2001 and 2002. Our understanding of the short-term behaviour of radionuclides in the aquatic Yenisey estuarine system has developed markedly within the last few years through the analyses of samples and the simulation work undertaken using different modeling tools. For example, tangential flow ultrafiltration techniques have been used to explore the significance of radionuclid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Adding socio-economic value to industry through the integration of artists in research and open innovation processes.'.

assistant: **Objectives**

The VERTIGO project provides a major opportunity to develop more inclusive, intercultural, and thus productive and innovative approaches to the participation of artists in ICT research activities and for promoting synergies between creative arts, businesses, research organizations and the society at general. If the digital economy of Europe is to prosper over the long term, then its full and diverse talent base must be effectively engaged into new and innovative research projects with commercial viability, and research, business, investment and art communities must work together towards these endeavours. Our proposal will fully support these objectives and contribute to set new policies for creating and nurturing links between Arts, Science & Technology in the ICT sector.The project will build from the H2020 ICT36-2016 call objectives and guideline of activities in order to propose a fresh approach, targeted specifically at the deployment of a brokerage service for integration of artists in ICT research & innovation projects and promotion of synergy between ICT research & business communities, entrepreneurs, investors and arts.We strongly believe in the role of arts and ICT as a trigger for business development and a catalyzer to Science, Technology, Engineering and Mathematics (STEM) promptness to innovate. We therefore situate our action in the framework of the STARTS (Science, Technology and the Arts) initiative supported by the European Commission with the aim of linking R&D and innovation with the art world including design and creative industries. We will build on the new Art-Innovation Forum, announced by Centre Pompidou’s President Serge Lasvignes in September 2015, and will aim at expanding IRCAM’s unique and successful model of R&D&I in sound and music technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Statistical data-mining in astrophysics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The full exploitation of science data is being impeded by statistical and computational intractability. Scientists are now deluged by large, complex data sets, and the scientific value of these data is presently lessened by the laborious efforts needed to analyze them. Therefore, the goal of this project is to develop and deploy new statistical data-mining algorithms to achieve computer-assisted discovery. Such intelligent systems will unburden scientists, allowing them to focus on understanding their resul ts and formulating new hypotheses. This ambition will be achieved through computational efficiency, scalability and autonomy.These research topics will be addressed in the domain of astrophysics, as astronomers are already overwhelmed by data. This multi-d isciplinary (computer science/ statistics/ astrophysics) research will focus on 3 broad areas: â¿¢ Clustering in high dimensional data, e.g., the development of fast n-point correlation function algorithms to fully understand the spatial distribution of ga laxies; â¿¢ Anomaly detection, e.g., the automated discovery of new astronomical phenomena in massive, multi-wavelength data sets; â¿¢ Fast kernel density estimation, e.g., the morphology-density relation of galaxies. These algorithms will be exported to d istributed Grid systems, especially the UK AstroGrid and the US Virtual Observatory. Dr Nichol is a recognized leader in the development of data-mining algorithms for massive astronomical data sets. He returns to the Institute of Cosmology & Gravitatio n, Portsmouth, after 12 years in the USA. The Institute has internationally recognised expertise in theoretical cosmology and grid computing, and is a partner in the UK National Cosmology Supercomputer Consortium, with its own advanced computing resources. Nichol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'DRES2Market: Technical, business and regulatory approaches to enhance the renewable energy capabilities to take part actively in the electricity and ancillary services markets'.

assistant: **Concept**

The main aim of the DRES2Market project is to develop a comprehensive and affordable approach to facilitate the effective participation of distributed generation based on renewable energies in the electricity markets, and enable to provide balancing and reserve services according to market criteriaDRES2Market is focused on overcoming the existing barriers (technology and regulatory framework) for developing the integration of these technologies, based on the following issues:-The evaluation of the existing technologies (power generation, energy storage solutions, smart technologies, etc.) to design appropriate approaches for the effective integration of distributed generation in the electricity and ancillary services markets, propose the evolution of the technology to fulfil with the requirements to participate in these markets and recommend standards for these technologies.-The analysis of the existing grid codes and markets rules in the European markets to assess their capacity to enable the participation of variable renewable energy.-The identification of opportunities for the active participation of final consumers (based on distributed generation) in the penetration of these technologies, according to market criteria, proposing collaborative schemes.-The identification of arguments of the positive impact of these technologies, to obtain the social acceptance of these technologies.This initiative includes validation procedures based on computing and simulating processes based on real conditions. DRES2Market consortium includes the key players for the system integration of variable renewable energy: balance responsible parties; market operators, grid operator; providers of technology solutions; prosumers; retailers that can develop the aggregator role; renewable ener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A comparative history of archives in late medieval and early modern Italy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Most historians work in archives, but generally have not made archives into their primary object of research. While we tend to be preoccupied by documentary loss, what is striking is the sheer amount of paperwork preserved over the centuries. We need to study the reasons for this preservation.This project wishes to study the history of the archives and of the chanceries that oversaw their production storage and organization in late medieval and early modern Italy: essentially from the creation of the first chanceries in city-states in the late twelfth century to the opening of the Archivi di Stato that, after the ancient states’ dissolution, preserved documents as tools for scholarship rather than administration. Because of its fragmented political history, concentrating on Italy means having access to the archives of a wide variety of regimes; in turn, as institutions pursuing similar functions, archives lend themselves to comparison and therefore such research may help us overcome the traditional disconnectedness in the study of Italy’s past.The project proposes to break significantly new ground, first, by adopting a comparative approach through the in-depth analysis of seven case studies and, second, by contextualising the study of archives away from institutional history in a wider social and cultural context, by focusing on six themes researched in six successive phases: 1) the political role of archives, and the efforts devoted by governments to their development; 2) their organization, subdivisions, referencing systems; 3) the material culture of documents and physical repositories as well as spatial locations; 4) the social characteristiscs of the staff; 5) the archives’ place in society, including their access and misuse; 6) their use by historians. As implied