RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transition metal carbides decoration of 3D graphene nanostructures for enhanced  electrocatalytic hydrogen production [CARBODOH2]' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The exhaustible nature of fossil fuels places our society in seek for alternative and renewable energy carriers. Hydrogen has attracted significant attention as it holds the highest specific energy density of any known fuel. In addition, it is a clean fuel that, whose consume produces only water, electricity, and heat. Water splitting through electrolysis is an environmentally responsible, carbon-free alternative technique for hydrogen generation. Water splitting takes place in an electrolytic cell (or electrolyzer). The hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) occur at the cathode and the anode of the cell, producing gaseous hydrogen and oxygen molecules, respectively. Heterogeneous electrocatalysis is a process that can accelerate these electrochemical reactions on the surface of catalysts materials. For the production of H2, the design and development of efficient catalysts towards the HER is of fundamental importance. Up today, noble metals of the platinum group (e.g. Rh, Pt, Ru) are the most attractive electrocatalysts for HER. Nevertheless, the high cost and scarcity of these materials limit their potential applications. Earth-abundant transition metals (TM) based catalysts also show great potential for the HER. Especially transition metal carbides (TMC) are very promising materials for this application, thanks to their performance and availability. In order to increase H2 generation per electrode surface area, it is beneficial to engineer catalysts with high active surface area (offering an increased amount of active sites). The present project is prepared placing this necessity in its core and aims towards the design of novel nanostructured TMCs which can exhibit a very efficient activity towards the HER. To address this challenge, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Replacement of microglia and tumor-associated macrophages as a novel cell therapy for pediatric high-grade gliomas' (REPLACE-TAM) under Horizon Europe.

assistant: **Objectives**

Pediatric high-grade gliomas are aggressive central nervous system (CNS) tumors with poor prognosis and no curative treatment options. Tumor-associated macrophages (TAM) represent one of the most abundant cell types of the tumor microenvironment (TME), and directly contribute to tumor-promoting and immunosuppressive mechanisms. Novel methods of CNS myeloid cell replacement provide a unique opportunity to effectively modify this critical tumor component. This project aims to overcome current treatment limitations through the preclinical development of adoptive cell therapeutic strategies targeting TAM in high-grade gliomas to reprogram the TME immune state:Through the depletion of TAM and microglia, combined with the transplantation of hematopoietic donor cells, the TME will be repopulated with graft-derived myeloid cells. We will investigate the resulting immunological and clinical impact in different models of high-grade glioma. To further increase the effectiveness of this approach, we will perturb dysfunctional immune pathways in donor cells. Transplanted gene-edited cells will permanently disrupt the immunosuppressive state of the TME and empower an enduring anti-cancer response by the host’s adaptive immune system. In an orthogonal approach, we will engineer donor cells that – after myeloid differentiation in the CNS – are able to specifically recognize tumor antigens and actively eliminate cancer cells.Collectively, my group will pioneer a novel treatment modality against brain cancer by replacing the CNS myeloid niche population with hematopoietic cells that can be engineered to withstand mechanisms of tumor resistance and attack malignant targets. The applicability of this approach in different models of pediatric high-grade glioma will emphasize its translation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Shifting perspectives: from macrophyte collapses (tipping element) to global environmental change mitigation agents' (SHIFT2SOLVE) targeting Horizon 2020.

assistant: **Abstract**

Environmental conditions in the Anthropocene are rapidly changing triggering important ecological shifts in the Earth system and approaching tipping-point levels faster than previously expected. Macrophytes are an important tipping element in the ocean, disproportionally contributing to climate regulation and in under global decline given the coexistence of multiple anthropogenic impacts. To date, most of the studies on macrophytes have focused on understanding their performance in relation to certain disturbances, but still few information exists about their overall capacity to mitigate global environmental change and their capacity to continue doing so in the future. This interdisciplinary project (SHIFT2SOLVE) comes timely at this aim addressing societal priorities for climate action and the efficiency of natural resources. The main objectives of the action are: 1) quantifying macrophytes’ capacity to buffer environmental change, 2) assessing macrophytes acclimatization and adaptive capacity, 3) forecast the resilience and mitigation capacity of macrophytes in the future based on IPCC climate scenarios and 4) use Unmanned Aerial Vehicles and machine learning to early identify ecosystem contractions at a landscape scale. These objectives will be accomplished by mixing surveys along natural gradients of temperature and ocean acidification (i.e. latitudinal gradients in the Western Mediterranean and natural CO2 vents), manipulative experiments in the field and in the laboratory, genetic analyses and mechanistic mathematical models based on ecophysiological processes. This project will importantly contribute to my career development and professional maturity increasing my independence as a researcher and the oportunities to continuing my research in Europe. Overall, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel flow focusing technology to produce microencapsulated probiotic bacteria for the food sector' (FLOCAP).

assistant: **Innovation**

Functional foods are designed to provide a specific and beneficial physiological effect on health and/or well-being beyond the provision of simple nutrients. With the current focus on disease prevention, the functional products market potential is enormous. Probiotic foods, containing health-promoting bacteria, are the most important and well-known group of functional foods. Commonly used probiotic bacteria belong to species normally living in the intestinal tract.However, illness, poor diet, stress, ageing, infections and the use of antibiotics and other medicines can destroy the balance between these beneficial species and other undesirable or pathogenic bacterial strains, which can then occupy the free niche. Against this, a regular intake of probiotic bacteria has been claimed to deliver health benefits such as strengthened immune system, reduced colon cancer risk, lowered cholesterol levels, prevention of diarrhoea, etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Smart Thermostat with Heating Power Adjustment' (CALORIC) targeting Horizon 2020.

assistant: **Abstract**

Heating in residential and commercial buildings is a basic need for the well being of the citizens. It is also a major cost in the family’s and businesses budget, that in most cases it cannot be avoided. The vast majority of this heating is produced through the combustion of fossil fuels in the buildings boilers locally, resulting in an impressive negative environmental impact in terms of greenhouse gas emissions and smoke pollution inside the cities, not to mention the high cost of the imported fuels. A low cost, highly efficient, easy to be installed solution that will reduce their heating cost without reducing their heating comfort, is needed. Buildings are responsible for approximately 40% of energy consumption and 36% of CO2 emissions in the EU. An essential part of Europe's clean energy transition is the changing role of buildings from energy consumers to actively controlling and optimizing indoor environment while contributing to energy system flexibility.Our company LIGHTHEAT P.C., has invented and developed the Caloric Smart Thermostat (CST). CST has three unique features, that bring a new age in the market of smart thermostats for heating systems with warm water radiators, the Heating Power Adjustment (HPA), the Heating Problem Detection (HPD), and the  ability  that gives to the user to control and anticipate the heating bill (HBA) with the Heating Hours Meter (HHM).CST switches on/off the heating when needed, for small intervals, controlling not only the inside temperature but also the temperature of the radiators (HPA) using a wireless temperature sensor. As a result the consumption (heating cost) may drop up to 50%, with more hours of heating comfort, protecting the environment at the same time. CALORIC  is a simple solution with a huge impact, because wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'BASE2 - Broadband Access Satellite Enabled Education' (BASE2).

assistant: **Innovation**

The scope of BASE project is to support key EU policies und validate space technology for public services and applications having a key economic and social impact at Union level in the field of education (distance Learning). The overall objective of this project is the implementation of an end-to-end system for tele-education applications, integrating broadband terrestrial networks with satellite broadband technologies Aim of the project is to facilitate the sustainable provision of integrated tele-educa tion services and applications to a large number of distributed interconnected sites over a variety of telecommunication infrastructures. Within the framework of the project is the seamless integration of Low-cost satellite telecommunications infrastructu res with broadband terrestrial systems will be investigated. The network will integrate satellite communication technologies with various terrestrial network infrastructures. An integrated end-to-end system will be implemented in order to provide tele-educ ation services to: a) remote, distributed and isolated rural areas and b) maritime users where satellite communication technologies have a potential edge over terrestrial infrastructures. Both of these user groups are tropical examples of economic activ ities which can greatly be benefited by a wider deployment and use of satellite communications essentially due to usually large distances which separate them from broadband terrestrial telecom infrastructures. European agriculture will benefit substantial ly by tele-education applications over satellite European farmers at remote areas are often producing specialised products of designated origin and require education to increase or very often guarantee the quantity and quality of their production. Mariti me workers a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NLRP3 in cancer: Deciphering the role of NLRP3 in the DNA Damage response pathway' (RoNDBioCan), addressing dissemination and exploitation.

assistant: **Impact**

Cancer represents one of the main causes of death in the European Union (WHO). Particularly, non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer-related death worldwide. Despite significant therapeutic improvements, the survival rate of patients with advanced stage NSCLC remains dismal, signifying a critical need to elucidate the molecular processes driving NSCLC. Inflammasomes are major drivers of inflammatory responses and are deregulated in a wide range of disorders, yet their participation in carcinogenesis is largely unknown. Genome analyses reported that the NLRP3 receptor, component of the NLRP3 inflammasome, is affected by somatic alterations in 20% of NSCLC. Moreover, recent evidence has shown that NLRP3 is essential for the activation of the ATM/CHK2 pathway in response to double strand breaks (DSBs), while its expression is systematically absent in NSCLC cells. Based on these data, we hypothesize that NLRP3 is a key factor in the DDR pathway to DSBs and in the maintenance of genome integrity in lung epithelial cells, and as a consequence may play a key tumor suppressor role. The objectives of RoNDBioCan will be to decipher the molecular mechanism of NLRP3 function in the DDR pathway and to evaluate the therapeutic potential associated with NLRP3 expression. By characterizing novel NLRP3 partners and examining the impact of NLRP3 re-expression on tumor development in vivo, RoNDBioCan will significantly improve the current knowledge regarding NLRP3 participation in lung cancer. Given that the poor outcome associated with NSCLC is mostly due to limited curative options, there is an urgent need to identify new biomarkers and additional treatments to reduce the current burden of lung cancer. This work will thus c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Space Thermoacoustic Radio-Isotopic Power System' under Seventh Framework.

assistant: **Concept**

The project relates to an advanced thermal to electric conversion for radio-isotopic power systems (RPS). Indeed RPSs are a key for space exploration as the solar power is very low in deep space, notably in Jupiter orbit and beyond. These systems will be also useful for Mars exploration, where solar power is subject to nights and dust storms.So Europe aims to get its independence for such missions, and ESA have initiated development of RPS. If thermoelectricity fits well with small RPS (e.g.20We), for 100We range, high efficiency conversion is desirable. Indeed this leads to save between 2/3 up to 3/4 of the radioisotope mass. This is of real importance in term of cost and safety. Stirling converters under development in USA have low reliability due to pistons (sensitive to launch vibrations and shocks, subject to wear).Thermo acoustic (TAc), coupled with magneto hydrodynamic (MHD) generator is innovating technology free of moving parts. Unfortunately, the Technological Readiness Level is low and the priority is given to Stirling in ESA’s programme, even if ESA has supported the first studies of TAc-MHD systems. This project is complementary with ESA’s approach.So, the objective of this proposal is to raise the TRL of this technology from 2 to 3-4 and show that this option is viable for European RPSs. The approach is based on 3 axes:Theoretical modeling, which has been already developed but needs to be validated,Experimentation of a thermo acoustic engine coupled with a MHD generator,Design of the space RPS, equipped with this conversion system, to check if the technology is suitable for space mission.The targets are:to validate the process efficiency (close to 20% or above),to justify the compatibility of the technology with space missions,In Europe, there is a st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DISCOVERING HOW PLANTS SENSE WATER STRESS' (HYDROSENSING), addressing dissemination and exploitation.

assistant: **Impact**

Water stress is an increasing probleWater stress is an increasing problem for global agriculture given the impact of climate change. Despite the fundamental importance of water, exactly how plants sense its availability remains unknown. This new knowledge is vital for designing more climate resilient crops, yet currently remains a critical gap in scientific understanding. Our unique synergy is ideal to take on this ambitious project and discover how plants sense water after identifying membrane proteins from a proof-of-principle multi-targeted genetic screen designed to reveal components of the water-sensing (hydrosensing) machinery. We hypothesise changes in plant hydraulic fluxes driven by transient water stress are sensed by a specialised cell type – termed phloem companion cells - that controls the synthesis and release of the abiotic stress signal ABA. Release of ABA by water stress is triggered by perturbations in plasma membrane-cell wall contact sensed by kinases like THESEUS1 (THE1) and additional missing components, which we will identify using our custom multi-targeted CIRSPR libraries. Our discoveries will unlock the mechanism enabling sensing of the most important molecule on the planet, WATER, in the most abundant lifeform biomass-wise, PLANTS.Solving how plants sense water demands a highly inter-disciplinary strategy that goes beyond the cutting edge by pioneering the development of innovative genome editing, functional imaging and structural biology approaches. The breadth and depth of capabilities and expertise to undertake this strategy necessitates a synergistic partnership between world-leading groups to go beyond the current state of the art. By pursuing this high-risk/high-gain strategy, our project promises to reveal common ‘design principles’ tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Vegetable Ozone Therapy Crops Sanitized Naturally from Seed to Feed' (OXIR) targeting Horizon 2020.

assistant: **Abstract**

Crop pests and disease have serious consequences for agriculture, in terms of economic losses and wastefulness of resources. In addition, according to the FAO, transboundary plant pests and diseases – growing in the last years because of globalization, trade and climate change, as well as reduced resilience in production systems due to decades of agricultural intensification - affect food crops, threatening food security. Agriculture is to be safe, healthy and sustainable, so it is essential to have healthy crops; they play a role in producing sufficient quantities of healthy foods and contribute to the quality of life.OXIR is an innovative technology for spraying aqueous ozone (O3) for disease control and sanitation of greenhouse crops, taking advantage of the powerful oxidation-based (hence non-selective) anti-pathogen action of ozone. OXIR offers two configurations adaptable to users’ needs a fixed and a mobile prototype, that will allow European farmers saving €6.000,00/ha/year due to reductions in chemicals and labour. Currently, existing solutions to fight crop pests and diseases include synthetic chemical pesticides – posing serious environmental concerns - and bio-pesticides – that are not strongly effective, as their pest spectrum is narrow. Compared to these solutions, OXIR is highly efficient against fungi and bacteria (85-99% removal) and viruses (90-99%); costs-effective: OXIR treatment saves working time (1 min. treatment; 20 min. safety interval) compared to biopesticides and chemicals; environmentally sustainable: OXIR is IPM compatible, sustainable, and does not leave polluting residues. The goal of the Phase 2 project is to upgrade OXIR from its current preproduction state to market readiness and develop the first commercial product.


**Keywords:** Oz