RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strong Modular proof Assistance: Reasoning across Theories', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Formal proof technology delivers an unparalleled level of certainty and security. Nevertheless, applying proof assistants to the verification of complex theories and designs is still extremely laborious. High profile certification projects, such as seL4, CompCert, and Flyspeck require tens of person-years. We recently demonstrated that this effort can be significantly reduced by combining reasoning and learning in so called hammer systems: 40% of the Flyspeck, HOL4, Isabelle/HOL, and Mizar top-level lemmas can be proved automatically.Today's early generation of hammers consists of individual systems limited to very few proof assistants. The accessible knowledge repositories are isolated, and there is no reuse of hammer components.It is possible to achieve a breakthrough in proof automation by developing new AI methods that combine reasoning knowledge and techniques into a smart hammer, that works over a very large part of today's formalized knowledge. The main goal of the project is to develop a strong and uniform learning-reasoning system available for multiple logical foundations. To achieve this, we will develop: (a) uniform learning methods, (b) reusable ATP encoding components for different foundational aspects, (c) integration of proof reconstruction, and (d) methods for knowledge extraction, reuse and content merging. The single proof advice system will be made available for multiple proof assistants and their vast heterogeneous libraries.The ultimate outcome is an advice system able to automatically prove half of Coq, ACL2, and Isabelle/ZF top-level theorems. Additionally we will significantly improve success rates for HOL provers and Mizar. The combined smart advice method together with the vast accumulated knowledge will result in a novel kind of tool, which a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Deconstructing the immunomodulatory checkpoints in metastasis to the cerebrospinal fluid'.

assistant: **Objectives**

While the healthy brain is largely devoid of lymphoid cells, the surrounding cerebrospinal fluid (CSF) is normally populated by lymphocytes. CSF hosts an array of threatening pathologies, including leptomeningeal metastasis with unusually poor prognosis. Despite the presence of immune cells, including CD8 T lymphocytes, this metastasis site does not respond to immunotherapy. My preliminary data demonstrate that the molecular profile and phenotypic behavior of these CSF CD8 T cells is inconsistent with conventional immune exhaustion. I hypothesize that CSF is an inherently immunosuppressive environment, protecting the brain from inflammatory insults directly by its composition. In CSFcheck, we will identify the individual components of the CSF that convey its immunosuppressive essence and manipulate the core CD8 T cell gene networks to disrupt the consequences of this phenomenon (Aim 1). We will investigate the fate, lifespan, and function of these cells after the metastasis encounter (Aim 2). Combining my experience with cutting-edge mouse immune modeling, systems-level computation, and functional assessment of human tissues, we will chart the immunosuppressive nature of the CSF and uncover the molecular pressure that CD8 T cells undergo upon entry to the CSF. This work will challenge and refine our understanding of the central nervous system immune privilege and communication with the periphery, exposing novel immunoregulatory mechanisms in metastasis that go beyond T-cell exhaustion.


**Keywords:** leptomeningeal metastasis, cerebrospinal fluid, CD8 T cells
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clearance of flight control laws using optimisation' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Before an aircraft can be tested in flight, it has to be proven to the authorities that the flight control system is safe and reliable, i.e. it has to go through a certification and qualification process. Currently significant time and money is spent by th e aeronautical industry on this task. An important part of the certification and qualification process is the clearance of flight control laws (CFCL). The overall objective of this project is to develop and apply optimisation techniques to CFCL in order to improve efficiency and reliability of the certification and qualification process. The application of an optimisation-based approach relies on clearance criteria derived from the certification and qualification requirements. To evaluate these criteria dif ferent types of models of the aircraft are employed, which usually both serve for clearance as well as for control law design purposes. The development of different models and of suitable clearance criteria are therefore also objectives of the project. Bec ause of wider applicability optimisation-based CFCL will open up the possibility to design innovative aircraft that today are out of the application field of classical clearance tools. Optimisation-based CFCL will not only increase safety but it will also simplify the whole certification and qualification process, thus reduce costs. The speedup achieved by using the new optimisation-based approach will also support rapid modelling and prototyping and reduce time to market". It is therefore believed that th e project is addressing the two top-level objectives of the Work Program, i.e. ". To meet society's needs for a more efficient, safer and environmentally friendly air transport. ". To win global leadership for European aeronautics, with a competitive supply cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AI that composes complex instrumental music for movies, games, advertising and other types of digital media' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Artificial intelligence is already affecting our daily lives. We are slowly growing to accept AI when it makes our lives safer or easier, but when it comes to creative pursuits we usually don’t feel the same way.Composing talent is rare, and as a result a soundtrack can take up to 6 months in composition time & up to €500,000 in costs. The scoring process for soundtracks of entertainment content is still based on century-old methods of hiring a lot of different profiles (composers, arrangers, orchestrators, musicians, studio engineers, music supervisors, publishers) to manage the creation of quality music. While soundtracks scored by professional teams usually end up being great, the process doesn’t scale to today’s increasingly high needs for music in a fast-evolving media market. We are building AI that has trained itself on 30,000+ of classical music pieces from world’s greatest composers. It developed an ability to compose soundtrack music that is full of emotion.AIVA is the first virtual artist that is recognized by SACEM—the French professional association that collects & distributes royalties and protects the rights of the original music creators. AIVA is the first AI composer that got commissioned to compose a piece for the National Day celebrations in Luxembourg & an anthem dedicated to the city of Dubai that were both performed in 2017 during the celebrations.We are transitioning AIVA from a service to an embeddable product—an automated composition tool (Music Engine) to be used in the existing video game engines to create hours of quality unique music to support the game play at a fraction of cost of human composers. We are also positioning AIVA as a support tool for composers to speed up their work.We plan to reach €26m revenues by 2023 with 200+ FTEs employ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Dynamics of Solidarity on Madagascar: An Ethnography of Political Conflicts and Appeasement Strategies in the Context of a Pronounced Consens Norm' (DySoMa).

assistant: **Innovation**

The aim of this anthropological research project is to improve understanding of the peace-making processes operating in the ongoing Malagasy political crisis. A dispute in 2009 over the Malagasy presidency, the most powerful political position on the island, marked the beginning of a particularly difficult period. At first tensions were limited to the national political level, but the situation rapidly degenerated into a more general social crisis as international support was suspended, the economy plummeted down and the population of about 22 million had to cope with great insecurity.In this period of acute risk to social order a number of unusual conflict resolution strategies were adopted independently. Alongside the official, internationally brokered negotiations, there were a number of distinctive, local mechanisms which had a clear, positive impact on the situation. The innovative institutional embodiment of a local concept of solidarity rooted in traditional ancestor worship (fihavanana) and popular justice movements led by charismatic personalities were amongst the most important in paving the way for conflict resolution and a new beginning for Madagascar.The rarity of such successful conflict resolution in post-colonial contexts arouses curiosity and demands close evaluation. An attractive scientific challenge is triggered, offering a unique opportunity to devise an ethnography of de-escalation and peace which will stand in contrast to the conventional focus on war and disorder. Anthropological fieldwork in Antananarivo (the Madagascan capital) and the Western Melaky region as well as historical research will furnish qualitative evidence for an insightful interpretation of the unique dynamics of solidarity observed.The project will contribute to a better unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'InfraStructures for broadband access in wireless/photonics and Integration of Strengths in Europe' (ISIS).

assistant: **Innovation**

In the context of increasing bandwidth, demands are going to both higher bit rate and to the convergence of telecommunication networks. Radio technology offers flexibility while optical fibre offers the required capacity. ISIS aims to strengthen European scientific and technological excellence in low cost optical solutions for broadband access merging wireless and photonic technologies. ISIS addresses broadband analogue and digital communication systems and the contribution from the optical technologies in the domain of micro/mm-wave  photonics for future broadband hybrid wireless/optical access. Low-cost access and edge network equipment, service-enabling technologies and platforms and increased bandwidth capacity are addressed, with advanced wireless network technology exploiting the millimetre-wave bands. ISIS is intended to develop an infrastructure with the integration of a critical mass of researchers from 19 organisations, all are recognised specialists in the area, from 10 European countries and two others. This project will allow Europe to have a dominant position  in this emerging field by integrating individual European excellence. The Joint Programme of Activities includes significant integrating activities with a joint use of infrastructures, mobility of researchers, and coordination of partners activities leading to specialisation. It includes also a joint technical research programme to develop joint research platforms and tools on broadband optoelectronic architectures and functions, broadband optoelectronic technologies, and optoelectronic broadband characterisation and test. Management of knowledge and activities to spread excellence are widely addressed : 6 workshops or seminars, 15 training courses and 3 summer schools are to be organised over the 3
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigative Support for the Elucidation of the Toxicological Impact of Nanoparticles on Human Health and the Environment', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The global aim of this project is to provide investigative support for the elucidation of the toxicological impact of nanoparticles on human health and the environment. It is aimed at area 3.4.1.5. of the Nanotechnologies and Nanosciences, Knowledge Based Multifunctional Materials, New Production Processes and Devices work programme. Public organisations and nanotechnology companies across Europe are under pressure to improve the safety of nanoparticles. In this project, they will document potential methods of dispersal and contamination by nanoparticles and agglomerated nanocrystals (e.g. sorption, desorption, transport, aggregation, deposition, bio-uptake). The review will also address the following issues: a)physical and chemical properties of different t ypes of nanoparticles and agglomerated nanocrystals; b)manufacturing and use; c)human health effects including side effects; d)animal toxicology; e)environmental impacts; f)mutagenicity/genotoxicity; g)metabolism/pharmacokinetics; h)standards for safe use; i)safe laboratory methods etc. Current research and development activities in Europe will be mapped and entered onto an on-line European database, which will be linked to existing web sites and databases of specialist groups. Standards, legislation, ethic al issues, policies and codes of practice, at international and European level, which have been put in place or are under development, will be assessed and reviewed. Their implications and effectiveness will be discussed. Ways in which existing legislation is applied to the macroscale counterparts of nanoparticles will also be examined. Guidelines and recommendations for the institution of future European standards, legislation, ethics, policies, and codes of practise, for the safe production and use of nan opart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Complementary research action to support sars-related diagnostic, therapeutics and vaccin'.

assistant: **Objectives**

Severe Acute Respiratory Syndrome (SARS) is a life-threatening form of pneumonia caused by a novel coronavirus (SARS-CoV). The prevention and/or containment of future outbreaks will depend on our understanding of SARS-CoV biology, pathogenesis, and evolution. An overall strategy to combat this novel virus needs to be designed, in particular using reliable diagnostic tools, specific antiviral compounds, and a SARS-CoV vaccine. The SARS-DTV consortium consists of a balanced mixture of scientists that have worked on coronaviruses for most of their professional career and specialists in other fields. The expertise of the first group covers coronavirus molecular biology, evolution and immunology. Complementary expertise, and state of the art technology, is supplied by partners specialized in structural biology, B- and T- cell immunology, in vivo model sytems, diagnostics and drug screening. Also a number of Asian partners participate in the consortium to ensure access to SARS-CoV-related materials and a constant dialogue with researchers in the primary SARS-affected area of the world and its rapidly developing SARS research programme. The overall objective of the SARS-DTV network is to contribute to the development of candidate anti- SARS-CoV drugs, vaccines and diagnostic assays, by collaborative and complementary research divided into four Work packages. Molecular targets for anti-SARS-CoV therapy will be identified and characterised in terms of structure and function. (Bio)chemical approaches will identify lead compounds" (candidate antiviral agents). The correlates of the humoral and cellularprotective anti-SARS-CoV immune response will be defined and the role of immunopathology in SARS will be addressed. The Model Systems work package aims to develop SARS- CoV reverse g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'IT for Error Remediation And Trapping Emergencies' under Seventh Framework.

assistant: **Concept**

In recent years, a variety of driver support and information management systems have been designed and implemented with the objective of improving safety as well as the performance of vehicles. While the crucial issues at a technical level have been mostly solved, their consequences on driver activity remains open and needs to be fully explained. Of particular importance are their effects on driver behaviour and strategies, and their impact on the operation and safety of the traffic system.  The aim of the proposed project is to develop and validate a unified model of driver behaviour and driver interaction with innovative technologies in emergency situations. This model will be applicable to and validated for all the surface transport modes. Drivers’ age, gender, education and experience and culture are factors that will be considered together with influences from the environment and the vehicle.  A unified model of driver behaviour will be of great use when designing innovative technologies since it will allow for assessment and tuning of the systems in a safe and controllable environment. At the concept stage, the model could guide designers in identifying potential problem areas whilst at the prototype stage, the model could inform on the scenarios to be used in system evaluation. In this way the systems will be better adapted to the drivers before being available on the market and will provide better support to the driver in emergency situations. Along the same lines, the model could be of use for authorities as a guide in assessing and approving innovative technologies without performing extensive simulator experiments or large scale field trials.  As far as the proposes are aware, there has not to date been any research taking the bold step of attempting to creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Minipigs as models for the toxicity testing of new medicines and chemicals: impact assessment' under Sixth Framework.

assistant: **Concept**

The RETHINK project will produce an impact assessment report on toxicity testing in the mini-pig as an alternative approach that can contribute to the replacement, refinement and reduction of animal testing (3Rs). The pig is close to man in terms of ana tomy, physiology and biochemistry and in consequence is an attractive model for safety evaluation and biomedical research, which may permit the replacement of dogs and monkeys and the more efficient and predictive use of biological resources and animal l ife. This promising approach is deserving of objective evaluation and this is the propitious moment, as legislation places greater emphasis on alternative approaches in safety evaluation (eg REACH initiative), and as toxicogenomics begins to make a cont ribution to safety issues. If the minipig is to provide a valid, realistic and robust alternative approach for use in the regulatory testing of new medicines and chemicals, while contributing to the 3Rs, there are issues that must be addressed in six div erse areas: (i) animal welfare, (ii) ethics, (iii) new medicines and chemicals development, (iv) validation of animals models in safety evaluation, (v) genomics and emerging technologies, and (vi) economic impact and overview issues. The Steering G roup (SG) of consortium members will assemble Working Groups (WG¿s) of recognised experts in each topic area and will provide WG¿s with methods to define a hierarchy of issues and develop responses. WG¿s will review and summarise the available body of kn owledge for their topic and prepare conclusions and recommendations, including identification of gaps in knowledge where further research is required, and technical gaps presenting obstacles to the use of minipigs. The WG documents will be finalised for a plenary meeting of exp