RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Re-inventing Ecosystem And Land-surface Models' (REALM) targeting Horizon 2020.

assistant: **Abstract**

Terrestrial ecosystems respond to changes in climate and the atmospheric environment, which they in turn help to regulate. As global change has become an international concern, high expectations have been laid on Earth system models with embedded ecosystem and biophysical land-surface components to deliver reliable, quantitative predictions of large-scale changes in ecosystems and their feedbacks to the climate system. But the lack of established quantitative theory for many fundamental processes – such as the long-term effects of temperature on primary production and carbon allocation, the sustainability and nutrient requirements of CO2 ‘fertilization’, and the regulation of green vegetation cover and its water use – has made such expectations impossible to fulfil. As a result, numerical models of land ecosystem processes continue stubbornly to disagree both with one another, and with benchmark data sets.This impasse can be overcome, but not without re-thinking modelling practice. Theory must be re-instated as the required link between observations and models. Multidisciplinary data resources now available should be used far more extensively and creatively. Observational and experimental results should be integral to model development, not merely used for ‘end-of-pipe’ testing of complex, poorly constrained models. I propose to develop a comprehensive, next-generation vegetation model using eco-evolutionary optimality hypotheses to generate testable predictions, and multiple data sources to provide tests. Initial results have demonstrated the remarkable power of this ‘strong inference’ approach to explain patterns seen in nature. The project will transform the practice of global vegetation and land-surface modelling and in doing so, establish the foundations of a more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Island plant radiations as models to understand adaptive evolution and predict responses to future climate change: an integrative and multiscale approach in Asteraceae' under Horizon Europe.

assistant: **Concept**

Biodiversity is disappearing at an unprecedented high pace in human history, with climate change being one of the main drivers of this loss. However, there are still major gaps in our understanding of how species evolve and how they may respond to climate change, making it difficult to take effective conservation action to halt this biodiversity loss. Oceanic islands - those that have never been connected to continental landmasses - are considered biodiversity hotspots, harbouring a unique biota as a result of explosive diversification events in which multiple species arise from a single ancestor (radiations). These radiations usually occur within a short period of time due to the rapid adaptation of species to new island environments (adaptive radiations). In the AsterAdapt project, two island plant radiations will be studied to learn about the  adaptation process behind high species diversification and to use this knowledge to predict the impact of climate change on oceanic island plants. Specifically, it aims to assess the extent to which the specific environmental conditions of the species have determined the evolution of species traits and their genetic differentiation. These environment-phenotype-genotype associations, together with the result of an experiment simulating an extreme drought event, will be projected into future climatic conditions to predict plant responses to climate change. Using a multidisciplinary and multiscale approach and integrating different data sources, AsterAdapt will answer apt research questions in evolutionary ecology and island biology, while contributing to addressing global priorities regarding the halt of biodiversity loss and the mitigation of the effects of climate change. The development of this project will foster my research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mutagenic chemotherapy and inhibition of mismatch repair as a strategy to boost anti-tumor immune response' under Horizon Europe.

assistant: **Concept**

In colorectal cancer (CRC), the efficacy of immunotherapy is currently limited to a small subgroup of tumors characterized by mismatch repair (MMR) deficiency. Conversely, little or no clinical benefit has been shown in the large majority of CRCs with MMR proficiency, which are accordingly defined as immune-cold tumors. Determining how to turn an immune-cold into a hot (immunotherapy responsive) tumor remains a major scientific challenge and an unmet clinical need. Building on our recent demonstration that cytotoxic agents can increase tumor mutational burden and induce an immunogenic MMR deficient (MMRd)-like profile in preclinical CRC models, we devised CHIMERA as an ERC-2025-PoC initiative. CHIMERA leverages a validated in vitro and in vivo workflow to assess a first-in-class MMR inhibitor in combination with rationally selected cytotoxic agents, with the objective of converting MMR proficient (MMRp) cold tumors into an immunotherapy-responsive hot state. The project translates concepts generated within the ERC-ADG into a development program that integrates available drugs with novel molecules, thereby extending immunotherapy applicability beyond the current MMRd subgroup. Ultimately, CHIMERA is designed to consolidate proof-of-concept evidence for an innovative therapeutic strategy, laying the foundation for subsequent clinical testing and broader patient benefit in immuno-oncology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'eXploring futurE humaN thermal bIoclimate pAthways'.

assistant: **Objectives**

Xenia refers to the ancient Greek concept of hospitality. It is a traditionally established host-guest relationship rooted in reciprocity. Earth (the host) has served this institutionalized notion for millions of years providing inhabitable conditions to humans (the guests), and thus, allowing them to thrive. However, the human activities of recent centuries have violated the Xenia rules leading to the disruption of the Earth’s climate. As a consequence, the planet is becoming less hospitable. The global warming and the consequent intensification of weather and climate extremes induce severe impacts to humans, including losses of millions of lives. The most important threat is related to the thermal environment. Extreme heat in particular, is responsible for more premature deaths than any other natural disaster, especially in cities due to the urban overheating. Exposure to incompatible with human life heat conditions is expected to increase in the future as climate change escalates. Yet, there is a critical lack of robustness concerning the projections of future heat-health outcomes. This is primarily driven by the fact that both thermo-physiological and behavioral adaptation of humans to local climates is ignored. In order to address this significant gap in future climate impact assessments, the current project will eXplore futurE humaN thermal bIoclimate pAthways (XENIA), considering the physiological and behavioral responses of different groups of people with particular focus on the most vulnerable.


**Keywords:** human-biometeorology; extreme heat; human thermal bioclimate; human health; diverse populations;autonomous adaptation; environmental epidemiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'For a Better Tomorrow: Social Enterprises on the Move' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project “For a Better Tomorrow: Social Enterprises on the Move (FAB-MOVE)” brings together researchers and practitioners in order to explore the question of how social enterprises can grow and flourish. These objectives will be achieved through a carefully crafted network of academic and non-academic partner organisations co-operating worldwide.Managers and practitioners of social enterprises often lack an easy access to the frontiers of science. FAB-MOVE will significantly improve the transfer of knowledge between academics and non-academics and thus increase the practical applicability of research findings. For an enduring sustainable impact, FAB-MOVE develops a teaching tool to educate (future) managers of social enterprises on how to set up their enterprise in a specific environment, how to combine business with a social goal, and how to develop strategies for growth and scaling-up. Currently there is a lack of knowledge about the influence of different social and economic environments on social enterprises. Local eco-systems and traditions have a decisive impact on the wellbeing, growth and potentials for scaling-up of social enterprises. FAB-MOVE focuses on the embeddedness of social enterprises and its impact on their evolution. It identifies crucial success factors for a sustainable development of these new and innovative organisations in an internationally comparative perspective.Thoroughly analysed case studies will serve as best practices by highlighting how social enterprises overcome crucial problems and manage to grow in different social areas and various regions around the world. In particular, the cases will shed light on how managers of social enterprises cooperate with stakeholders and how their environment composed of promoting actors and existing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Genes regulated by rhd6 during root hairs development in arabidopsis'.

assistant: **Concept**

Arabidopsis roots hairs are a good system to study cell differentiation and morphogenesis in plants. The study of their development is also of great interest because of their putative function in nutrient assimilation. Recent works in the receiving institute have identified RHD6 as a putative transcriptional regulator specifically expressed in root hair cells and essential for root hair development. Thus, RHD6 may regulate genes involved in root hair development. We propose to use genome arrays to identify genes that are regulated by RHD6. In a first step, RNAs from wild type and rhd6 roots will be compared. In a second step, we will identify the direct targets of RHD6 by using the GR-dexamethasone system to analyze RNAs regulated by the induction of RHD6 expression in the rhd6- background. Selected isolated genes will be studied by in situ hybridization and reverse genetic approaches. This project in root hair development will allow me to increase my knowledge in plant development. The field of research is sufficiently important to allow publication in journals of high impact. I already have a good background in molecular biology and plant biology that will allow me to contribute greatly to the host group program on root development. However, the project will allow me to practice genome arrays and some cell biology techniques (including in situ hybridization) that are new for me. The John Innes Center is a top class-training site for post doctoral researchers that will allow me to assist to and to present many seminars and to have contacts with a large community of plant biologist. This will be important to increase my competences in this field of research in the aim to postulate to positions in public research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving Local Energy and climate policy through quality management and certification' (IMPLEMENT).

assistant: **Concept**

Climate change is a global problem and to solve it, we need to start on local level. To effectively implement energy and climate policies, concerted and strong action is needed. Municipalities often have ambitious goals and political will, but lack the harmonized, interdepartmental and long-term structures to successfully implement their climate and energy strategies and thus reach their goal.This is the starting point for the project, which focuses on capacity building in municipalities. By introducing the quality management and certification programme European Energy Award (eea) in Belgium, Croatia, Greece and Poland, the project aims at setting up the necessary structures in municipalities. During the project, 30 pilot municipalities will further develop and implement their climate and energy strategy by using the eea standards and criteria catalogue. External advisors will guide and monitor the continuous progress. Its certification will ensure that municipalities implement their climate and energy plans to high quality standards. The certification process is ongoing and ensures that municipal climate action progress. Their experiences and successes will pave the way for more municipalities in the target regions to join the eea. IMPLEMENT’s objective is to set up the necessary structures for a long-term roll-out of the eea in the partner countries. Partners will translate and adapt all eea tools to national context, receive adequate training to become skilled eea advisors, able to advice and guide pilot municipalities through the eea process. The consortium together with regional authorities will develop, based on experience exchange with eea expert regions, feasibility studies and business plans, tailor-made support schemes for the participating countries.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Validation of Integrated Safety-enhanced Intelligent flight cONtrol', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

To enhance air transport safety, the main objective of VISION is to validate smarter technologies for aircraft Guidance, Navigation and Control (GN&C) by including 1/ vision-based systems 2/ advanced detection and resilient methods. Critical flight situations are targeted, especially during near-ground operation phases (half of 169 fatal accidents in the last decade during approach or landing). Actually, despite continuous improvements in reliability and performance, the complexity of Flight Control Systems also requires to use many sources likely to suffer from faults and environmental conditions. To overcome these anomalies, recent projects have evaluated advanced solutions, but their transfer to the industry is slowed down by lack of flight validations, limitations of on-board computers or certification issues. The TRL reached by both sides are rather equivalent, with dissimilar pros and cons. Accordingly, VISION aims at capitalizing on the know-how and experience independently acquired to make a significant improvement and maturation of the TRL achieved. To demonstrate the solutions, complementary efforts will be undertaken and two scenarios are considered: i) Flight control recovery, ii) Navigation and guidance recovery during the final approach phase. In i), Fault Detection and Diagnosis and Fault Tolerant Control techniques will be implemented in faulty situations. In ii), vision will be used to estimate and modify the aircraft glide path when local navigation data is denied, or when unexpected obstacles are detected. In both cases, the GN&C systems will be tested on real aircraft platforms and their performance evaluated. VISION will result in flight-validated GN&C solutions with increased TRL, with benefits for the European aircraft industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chromatin organization PROfiling with high-throughput super-resolution microscopy on a CHIP' (PROCHIP) under Horizon 2020.

assistant: **Objectives**

Cancer is both a genetic and an epigenetic disease whose outcome is influenced by tumor microenvironment, which represents the major driving force of tumorigenesis causing the functional heterogeneity observed in most cancer types. Defining the 3D-organization of cancer-associated chromatin domains would represent a new frontier to decipher tumor heterogeneity. None of the currently available technologies permit to rapidly analyze thousands of cells and profile their chromatin organization at single cell level, as needed for medical diagnosis and therapeutic guidance. The goal of the project is to build a high-throughput super-resolution microscope in a microfluidic chip smaller than a coin. With this device we will provide high resolution imaging of hundreds of cells at the diffraction limit and beyond, with minimal photo-toxicity. Femtosecond laser micromachining allows fabricating with accurate precision optofluidic components as waveguides, microchannels and lenses in a glass substrate. We will integrate them in a single chip, to achieve the required illumination path for advanced fluorescence excitation and sample movement: in the same chip biological samples will be scanned along fluidic channels in a fully automatic fashion.High-throughput data on chromatin distribution in hundreds of samples will be generated, allowing to decipher the pathogenic function of tumor heterogeneities in tumor progression. These data will be used as benchmarks for predicting differential responsiveness and/or resistance of cancer cells to targeted therapies opening brand new possibilities for medical diagnosis and therapeutic guidance. The consortium is formed by young scientists from Universities in the field of photonics, computer sciences and epigenetics, and a leading company in m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of new antigenic peptides recognized on human tumor cells by cytolytic t lymphocytes' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Several antigens have been identified that are recognized on human tumors by autologous cytolytic T lymphocytes (CTL). Many of these antigens are encoded by MAGE genes that are very selectively expressed by tumor cells. Therefore it is now reasonnable to try to immunize cancer patients against such tumor antigens to induce tumor rejection. Nevertheless, patients would be eligible for such immunotherapy only if their tumor cells express the relevant HLA molecule together with the gene coding for the antigenic peptide. We intend to find new antigenic peptides encoded by the MAGE genes, in order to allow more patients to benefit from antitumor vaccines containing these antigens. Because some of these MAGE genes code for large proteins, we expect that some peptides corresponding to several regions of these proteins can combine with other HLA molecules to form antigens for anti-tumor CTL. A first strategy consists in searching the protein sequences for peptides containing HLA binding motifs, testing their binding in vitro to the relevant HLA molecule, and using the best candidates to stimulate T lymphocytes. An alternative method is to transfect dendritic cells or to load them with recombinant protein, and use these modified dendritic cells to induce primary antigen-specific CTL response in vitro. Advantages of this strategy include the covering of a complete protein with fewer experiments, and a more physiologic selection of the CTL epitopes by the antigen-presenting cells themselves. Training content (objective, benefit and expected impact) The first objective of this training is learning techniques in molecular and cellular immunology in order to be able to identify potential tumor specific antigens. The Cellular Genetics Unit of the ICP ha