RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Refactoring monoterpenoid indole alkaloid production in microbial cell factories' (MIAMi) targeting Horizon 2020.

assistant: **Abstract**

Plants produce some of the most potent human therapeutics and have been used for millennia to treat illnesses. The monoterpenoid indole alkaloids (MIAs) are plant secondary metabolites that show a remarkable structural diversity and pharmaceutically valuable biological activities with more than 2,000 MIAs derived from the common precursor strictosidine. However, because most MIA chemicals do not have their biosynthetic pathways elucidated and MIA-producing plants are not genetically trackable, MIAs are under-represented in recently introduced medicines. In the consortium for Refactoring of Monoterpenoid Indole Alkaloids in Microbial Cell Factories (MIAMi) our main objective is to develop sustainable microbial production of new human therapies for the benefit of the European biotech industry, human health, and the environment. To do so, MIAMi will i) develop a new approach for MIA biosynthetic pathway discovery in plants founded on supervised learning algorithms based on omics data sampled from > 20 MIA producing plants, ii) contribute to standardisation of bioengineering by development of SOPs for characterisation of > 100 DNA elements for control of gene expression, protein interactions, and sub-cellular localisation, iii) build a public parts repository and Bio-CAD for forward engineering of compartmentalised biosynthetic pathway designs in yeast, and iv) apply automated genome engineering to prototype > 1,000 new-to-nature MIA biosynthetic pathway designs in order to identify robust designs for scale-up microbial MIA production processes, and evaluate the environmental benefits and risks compared to existing value chains. The excellent, interdisciplinary and inter-sectorial consortium will showcase the use of the new approaches and standardised data inventory to prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sounds of Royalty: Accessing Valois Soundscapes (c. 1400) Digitally' (VALSOUNDS) targeting Horizon Europe.

assistant: **Abstract**

The VALSOUNDS project will design a prototype multimedia digital valorisation tool that allows museums and cultural heritage institutions to highlight the sonic aspects of their collections or sites. This will be done through an innovative, immersive (3-D, AR) digital interface with a focus on audio. Existing applications tend to privilege visual communication (images, text), deploying no or inadequate audio components. This ‘sonic gap’ often means missing out on sonic aspects that are crucial for fully appreciating and experiencing the cultural meaning of a given site or object. A significant number of sites has also been irrevocably altered or destroyed, making it impossible by analogue means to produce the sounds required for a historically informed hearing experience.  The new field of archaeo-acoustics enables digital reconstructions (‘auralizations’) of lost or altered spaces and sites. Existing case studies concerning the European Middle Ages were carried out primarily on sacred spaces (e.g., Pentcheva & Abel 2017), and only quite recently on court architecture (Sluyts et al. 2021). VALSOUNDS will build on the latter and conduct a case study of Valois palaces (c. 1400). The Valois courts have long been identified as sites of some of the most significant musical developments of their time; but they were also sites of conspicuous architectural innovation, making them a prime object for archaeo-acoustic study. Through a collaboration of acousticians, architectural historians, historical musicologists, heritage sites, performers, and private enterprise, VALSOUNDS reconstructs the Valois courts’ soundscape digitally, and embeds the resulting audio experience in an immersive multimedia environment that will be both sustainable and transferable for similar mediation con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Production technologies for micro systems' (PRODUCTION4OE).

assistant: **Concept**

Production4µ aims at enabling high precision manufacturing process chains to respond flexibly, cost-effectively and lot size adjusted to the need of micro system suppliers for the production of complex shaped and functional µ-parts; here: of µ-glass part s and for the use in optical and micro-fluidic systems. Objective of the Production4µ project is the investigation and application/verification of radical new production concepts, utilising new methodologies and standards as well as radical new manufacturing processes and automation technologies to transfer lab-scale prototype production into industrial scale production of µ-glass-components. Breakthroughs will be created in the developing of - reliable high volume µ-manufacturing technologies based on precision glass moulding, - radical new systems for automated handling and alignment of µ-components - new standards for µ-production planning, cost estimation and 'design for manufacturing'.High potential applications for µ-systems related products are to be found in the diverse automotive, biotech, medical and consumer applications and are current drivers of future economic growth for European industry. Increasing people's desire in mobility, communication and health forces the addressed sectors to realize product functionalities and performance. Main enablers are µ-optic as well as µ-fluidic components based on advanced glass material, due to its superior properties. If these components can be produced in high volumes to acceptable costs Europe faces an enormous economic potential, for example in optical systems integration for cars or mobile phones. However, despite of the economic potential the condition for industrial scale µ-production of such systems does not yet exist.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bioactive compounds from seafood byproducts' (BIOSEAFOOD), addressing dissemination and exploitation.

assistant: **Impact**

This project aims to follow the fate of three groups of aquatic bioactive compound from raw material to active cellular site; long-chain omega-3 polyunsaturated fatty acids (omega-3 PUFA), fish peptides and seaweed polyphenols.  The focus is to study if there are bioactivity losses prior to ingestion (i.e. during storage in a food product) or during gastrointestinal (GI) digestion and investigate wether there may be potential positive/deleterious effects of the compounds after digestion.  This work will be done in collaboration with Chalmers University and University of Florida, USA.  Omega-3 PUFA are highly prone to oxidation.  No research has been done to clarify their oxidation under GI passage, which may be highly pro-oxidative. Few studies have linked putative ex vivo PUFA oxidation in food products with changes in bioactive responses after digestion and cellular uptake.  Also, interaction between the PUFA and peptides/polyphenols in this chain of events is a novel research focus.  The impact of dosage and food matrix formulation for the interplay addressed will be of special importance in development of safe functional food products with aquati bioactives.  The project is divided into four work packages: (1) Production/analysis of three bioactive compounds, (2) Stability of bioactives alone or in a food model, (3) GI-oxidation/antioxidation of omega-3 PUFA, peptides and polyphenols using static/dynamic models, and (4) Effect of bioactives digests on antioxidative/oxidative and anti-inflammatory responses in cells.  The outcomes will aid toxicologists to develop biomarkers and validate safety of bioactives, nutritionists to design dietary guidelines, food industry to optimizing functional food product formulations and the public to better understanding how to eat t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D integration technology for silicon spin qubits' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Originally conceived to describe the microscopic world of atoms and elementary particles, the theory of quantum mechanics has eventually served to predict macroscopic phenomena, e.g. the electrical and optical properties of semiconductors, resulting a wide range of technological applications that have changed our way of living. Foundational properties like quantum superposition and entanglement, however, have remained essentially unexploited.  Their use may allow achieving computational powers inaccessible to classical digital computers, opening unprecedented opportunities. In a quantum computer, the elementary bits of information are encoded onto two-level quantum systems called qubits. Since qubits interact with the uncontrolled degrees of freedom of their environment, the evolution of their quantum states can become quickly unpredictable, leading to a reduced qubit fidelity. In topological quantum computing schemes, e.g. the surface code, the reduced fidelity is compensated by using decoherence-free logical qubits consisting of a large number (~103) of entangled physical qubits. As a result, a useful quantum processor should host at least millions of qubits. Although dauntingly large, this number is still small as compared to the number of transistors in a modern silicon microprocessors. QuCube leverages industrial-level silicon technology to realize a quantum processor containing hundreds of spin qubits confined to a two-dimensional array of electrostatically defined silicon quantum dots. To face the challenge of addressing the qubits individually, we use a three-dimensional architecture purposely designed to accommodate, on separated planes, the charge sensing devices necessary for qubit readout, and the metal gate lines for the electrical control and measurement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Atomistic Electrodynamics-Quantum Mechanical Framework for Characterizing, Manipulating and Optimizing Nonlinear Optical Processes in 2D Materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Two-dimensional (2D) materials, which include graphene, phosphorene, and transition metal dichalcogenides monolayers, exhibit extraordinary linear and nonlinear optical properties not attainable in bulk media. They find tremendous potentials in many photonic and optoelectronic applications, such as all-optical signal processing, optical amplification, nonlinear switching, optical microscopy, quantum detection, and sensing. The availability of first-principle, fast, efficient computer codes is a prerequisite to the bottom-up design of 2D materials. However, theoretical modeling of 2D materials faces great challenges as it needs to incorporate effects of finite size, edge truncation, periodic modulation, nonlocal, and quantum confinement. Here, we aim at developing atomistic electrodynamics-quantum mechanical theoretical models and implementing them in high-performance computing (HPC) software for characterizing, manipulating, and optimizing nonlinear optical processes (NOP) in 2D materials. The main objectives of this ambitious project are: (1) To develop a macroscopic electrodynamics approach for simulating NOP in 2D materials. (2) To develop an atomistic electrodynamics quantum mechanical framework for modeling NOP in 2D materials and compare the atomistic model to the macroscopic approach. (3) To develop user-friendly and reliable HPC software that seamlessly integrates and implements the theoretical models. (4) Using the software and theoretical models, emerging applications of 2D materials will be investigated, including solar cells, nonlinear microscopy, and biosensing. The project will have high impacts on: (1) advances in the science, technology, and industry of UK and Europe; (2) applicant’s future career development; (3) research, industrial, and transferrable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'SIGNALING INSECT PEPTIDES AS NATURAL INSECTICIDES FOR CROP PROTECTION (SIPs)'.

assistant: **Objectives**

The overall goal of the proposed project is to develop a novel way to control insect pests. The project will assess the feasibility of protecting crops from insect attacks by expressing naturally occurring insect signaling peptides in plants.Modern agriculture faces the challenge to secure the food supply in an environmentally compatible manner. Weeds, diseases and pests are among the most serious problems threatening the production of a successful harvest. The tools at the disposal of the farmer to combat insects include adapted crop varieties and pest management programmes. Breeding for insect resistant crop varieties is often hampered by a lack of resistance alleles present in the germplasm. The use of chemical insecticides (and pesticides in general) is more and more criticized because of potential environmental problems which may accrue. Biological control with baculovirus, bacteria, fungi or parasitic wasps, represents less than 1% of the chemical insecticide sales and only finds application in specific circumstances.Bacillus thuringiensis toxins are now widely used. However, the major threat to the Bt-plant technology, although very successful at this moment, is the potential of insect populations to develop resistance (Van Rie et al., 1995). It is now the right time to proceed with the research to find novel insecticidal toxins as alternatives for Bt-toxins when Bt-resistance would become a major problem.In this project we propose to explore an alternative approach for generating insect tolerant crops varieties. Since 1985, insect physiologists have discovered about 100 different insect signaling peptides. We have identified a set of such peptides which we think to have the potential to become a new class of insecticides. These peptides control different physiol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Adaptive Optical Microscopy Systems: Unifying theory, practice and applications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Recent technological advances in optical microscopy have vastly broadened the possibilities for applications in the biomedical sciences. Fluorescence microscopy is the central tool for investigation of molecular structures and dynamics that take place in the cellular and tissue environment. Coupled with progress in labeling methods, these microscopes permit observation of biological structures and processes with unprecedented sensitivity and resolution. This work has been enabled by the engineering development of diverse optical systems that provide different capabilities for the imaging toolkit. All such methods rely upon high fidelity optics to provide optimal resolution and efficiency, but they all suffer from aberrations caused by refractive index variations within the specimen. It is widely accepted that in many applications this fundamental problem prevents optimum operation and limits capability. Adaptive optics (AO) has been introduced to overcome these limitations by correcting aberrations and a range of demonstrations has shown clearly its potential. Indeed, it shows great promise to improve virtually all types of research or commercial microscopes, but significant challenges must still be met before AO can be widely implemented in routine imaging. Current advances are being made through development of bespoke AO solutions to individual imaging tasks. However, the diversity of microscopy methods means that individual solutions are often not translatable to other systems. This proposal is directed towards the creation of theoretical and practical frameworks that tie together AO concepts and provide a suite of scientific tools with broad application. This will be achieved through a systems approach that encompasses theoretical modelling, optical engineering and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ULTRAsensitive PLAsmonic devices for early CAncer Diagnosis' (ULTRAPLACAD).

assistant: **Innovation**

Cancer biomarkers circulating in body fluids have been shown to reflect the pathological process and for this reason can be used for cancer diagnosis, prognosis and choice for therapeutic interventions. It is proven that their detection is a key to new minimal-invasive detection approaches. However, barriers to wide spread use of similar approaches are lack of test sensitivity, specificity and limited availability of low cost detection platforms. This project is focused at developing a compact plasmonic-based device with integrated microfluidic circuit and functionalized nanostructures for the detection of DNA, microRNA and tumor autoantibodies cancer biomarkers. The aim is to detect cancer biomarkers circulating in blood with improvement in sensitivity of factor up to 1000, reduction in cost of platform of factor ranging from 2 to 4 compared to today’s available techniques and analysis time less than 60 minutes. The proposed detection approache will provide ultrasensitive detection of biomolecular systems with no need for complex sample chemical modifications thus allowing direct and simple assays to be performed. Within the project a bimodal industrial prototype will be developed integrating novel surface plasmon resonance imaging and plasmon-enhanced fluorescence sensing technologies, respectively. Automated fabrication processes suitable for low cost mass production will be developed and applied to produce disposable integrated chips. Prototype will be specifically fabricated for early diagnosis and prognosis  of colorectal cancer. The team includes partners holding cross-disciplinary competencies needed to achieve the proposed results, including two of the first five plasmon resonance groups in the world, the inventor of surface plasmon microscopy – also known as s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploiting the MSP-AMPK pathway for amelioration of NASH' to be submitted under Seventh Framework.

assistant: **Abstract**

BACKGROUNDNon–alcoholic steatohepatitis (NASH) is the hepatic event of the metabolic syndrome and is characterized by steatosis and inflammation. Although our understanding of the disease mechanisms has progressed, the therapy options for treatment of NASH remain poor. AMP-activated protein kinase (AMPK) is an important integrator of signals managing energy balance and acts as a protective response to energy stress during metabolic deregulations. Pharmacologic AMPK activation is a well-established treatment strategy against the metabolic syndrome and has been reported to ameliorate steatosis, but accumulating evidence suggests that global AMPK activation is undesirable, especially because of affecting appetite. Macrophage-stimulating protein (MSP) is a multifunctional serum factor secreted from liver cells and a ligand for Recepteur d'origine nantais (RON) receptor tyrosine kinase to initiate downstream signaling pathways in an autocrine fashion. MSP exhibits anti-inflammatory properties on macrophages. Interestingly, MSP-deficient mice on normal diet develop hepatic steatosis. However, the role of MSP in normal liver metabolism and metabolic syndrome remained underexplored. Previous studies by the applicant demonstrated MSP as a negative regulator of hepatic gluconeogenesis and of inflammatory responses, both via AMPK activation.HYPOTHESISMSP-mediated activation of AMPK is an effective treatment option against NASH.OBJECTIVES1) Investigate the molecular mechanism and metabolic/anti-inflammatory action of MSP-mediated AMPK activation in cultured hepatocytes and macrophages.2) Stimulate the MSP/AMPK pathway in liver to assess the potential of ameliorating NASH in relevant mouse models.DELIVERABLES1)  Identification of novel upstream regulators of AMPK downstream of MSP/R