RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Container Security  Advanced Information Networking' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

CONTAIN will specify and demonstrate a European Shipping Containers Surveillance system which will encompass regulatory, policy and standardisation recommendations, new business models and advanced container security management capabilities. CONTAIN will:1.Support transport security stakeholders in managing container security threats as part of an integrated approach to the management of transportation networks;2.Provide a coherent set of technology options for screening and scanning plus container-integrated sensor, communication and security technologies to monitor container movements and security related parameters in real time;3.Enable ports to establish upgraded port container security processes and provide information feeds to port community systems and national and European security databases;4.Provide information gathering, validation, fusion and situation awareness services to establish dependable near real time ‘corridor container traffic maps’ and their integration into a EU Container Traffic Map for use by organisations and systems established to promote and implement an integrated EU surveillance policy;5.Assist policy makers at national and EU level to benchmark container security performance and formulate improvement policies.The project will:1.Work actively on standardisation activities as a key enabler of cost effective solutions for shipping containers security with the ultimate goal to progress towards a single international shipping containers security standard.2.Build on outputs from ongoing FP7 projects on security, freight transport and ICT and efforts to establish integration facilities between security agencies such as FRONTEX and EMSA and EU Platforms such as e-Customs and SafeSeaNet.3.Demonstrate Secure Multimodal Corridor Design and Chain Mon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enzymatic DNA deamination and the immunity/cancer balance'.

assistant: **Objectives**

Genomic instability is a key hallmark of cancer. Chromosome translocations require the formation of pairs of double-strand breaks (DSB) and trans-chromosomal ligation of the broken ends. Members of the AID/APOBEC family of enzymes deaminate cytosine (C) to uracil (U) in the context of a polynucleotide substrate. Excision of the U residue from DNA produces an abasic site, leading to incision of the DNA strand containing the abasic site by the conventional base-excision repair pathway. The introduction of proximal incisions on both DNA strands can generate a DSB intermediate for chromosomal translocation. AID acts on C residues at immunoglobulin loci in activated B cells to trigger antibody gene diversification and is the only member of the AID/APOBEC family that is currently known to act physiologically on endogenous nuclear DNA. Off-target deamination by AID results in nucleotide substitutions and genomic rearrangements in B lymphocyte tumours. APOBEC1 edits mRNA transcripts in the small intestine. Liver-directed misexpression of APOBEC1 is oncogenic in transgenic mice. APOBEC3 enzymes are ubiquitously expressed and act on C residues in the cDNA viral replication intermediates as part of a host restriction pathway. APOBEC3A and APOBEC3B have been shown to be capable of causing genomic damage in mammalian cells. Access to the nucleus by APOBEC family members likely permits DNA deamination activity that introduces mutations and genomic instability during tumourigenesis. I have generated mice that harbour FLAG-tagged forms of AID, APOBEC1, APOBEC3A or APOBEC3B inserted at the ROSA26 locus, preceded by a floxed stop sequence for conditional expression. This system will be used to understand the role of cytosine deamination in tumour progression in tissue- and time-specific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Searching for Supersymmetry in Low Energy Electroweak Precision Data in the Framework of the MSSM and its Extensions' to be submitted under Fourth Framework.

assistant: **Abstract**

Researcn objectives and contentOur proposal is concetrated mainly on two particular subjects. One topic concerns the detailed quantitative study of the MSSM and its Grand Unified extensions, and the comparison of its parameters to existing precision data. A second topic is dealing with the exotic interactions that violate Lepton and / or Baryon number and do not respect it-parity. Particularly, on the first topic we plan to do higher order calculations in the electroweak observables in the framework of radiative symmetry breaking and the unification of gauge couplings. In the same framework, we will examine the dangerous" directions of charge and colour breaking minima, including improvements on the effective potential or threshold effects which come from a Grand Unified Model or a Superstring inspired Model. On the second topic, we plan to work on a project connecting the HERA data with the it-parity violated version of the MSSM and its extensions. We plan to merge the two topics by including the above stated precision calculation of the Z-observables and of the "fatal" charge and colour directions in the it-parity violated scenario of Th~ MSSM.Training content (objective, benefit and expected impact)My benefit from this project would be to improve my scientific knowledge of new innovative aspects of supersymmetry an field theory. I believe that this Marie-Curie project will enable me to acquire a fresh or deeper knowledge of the physics c elementary particles."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Experimental reconstruction of volcanic explosions: understanding the fragmentation energy balance and seismic signals' in the context of a Seventh Framework call.

assistant: **Objectives**

Volcanic explosions can have devastating effects on their surrounding area and communtiies, so it is important to improve our understanding of the controls on how energetic volcanic explosions are and the interpretation of the seismic signals that they generate. Volcanic explosions are driven by ascent and depressurisation of magma, which result in the exsolution of large volumes of gas. If the gas cannot escape through permeable pathways, pressure in the magma will build up, resulting in fragmentation and explosion of the magma. Recent work by the host has identified the influence of permeability, pressure, and magma properties on whether and how the magma will fragment. They have also developed methods to assess the energy used to fragment the magma from the size distribution of the fragments. In this project, the fellow will extend this work by conducting fragmentation experiments on natural and synthetic melts with a range of physical properties at a range of temperatures and pressures. The fragment size distribution will be analysed in order to calculate the energy partitioning between fragmentation of magma and ejection and propulsion of the fragments. This will be compared between different magmas in different states. During these experiments acoustic emissions, which are laboratory scale earthquakes, will be recorded. These can be scaled for comparison with seismic events recorded during volcanic explosions. Changes in the size and characteristics of these acoustic emissions with explosion energy, magma state and energy partitioning will be analysed. These results will inform the interpretation of seismic events associated with volcanic explosions, revealing links between the nature of explosion earthquakes and the potential impact of the volcanic explosion. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative Therapeutic Strategies for Mixed Lineage Leukemia-rearranged B-cell Acute Lymphoblastic Leukemia' (InTheMLLrBALL).

assistant: **Innovation**

B-cell acute lymphoblastic leukemia (B-ALL) is the commonest cancer in children and B-ALL with mixed-lineage leukemia rearrangements (MLLr) has a particularly dismal prognosis compared with other B-ALLs. Many MLLrB-ALL patients are refractory to chemotherapy and eventually relapse. Thus, MLLrB-ALL remains clinically challenging. Adoptive transfer of T cells engineered to express artificial chimeric antigen (Ag) receptors (CARs) targeting tumor cell surface-specific Ag is an exciting new approach for cancer immunotherapy.Clinical trials in patients with advanced B-ALL treated with CAR-T cells against CD19 have shown impressive disease remission; however relapse still occurs with loss of CD19. Importantly, the B-ALL patients who have not responded to CD19 CAR-T cells were mainly those carrying MLLr. A strategy to offset tumor Ag-loss relapse is to modify T cells with one CAR molecule containing two different binding domains in tandem (bispecific CAR). By using both in vitro and in vivo approaches, I plan to improve CD19 CAR-T cell therapy for MLLrB-ALL by i)developing a novel bispecific CD19/NG2 CAR, which we expect will reduce single-Ag immune pressure, and ii)through the combination of CD19 CAR-T cell therapy with P-D1/PD-L1 blockade.How to achieve a long-term persistence of CAR-T cells in the host still remains a major challenge in adoptive T cell immunotherapy, and therefore understanding the interplay between T cells, MLLrB-ALL blasts and mesenchymal stromal cells/stroma is fundamental to improve the efficiency of this immunotherapy. We will thus address in vitro and in vivo the contribution of the leukemia microenvironment to CAR-T cell efficacy, as a potential tumor microenvironment (PD1/PD1L)-mediated indirect mechanism of immune escape to CAR T-cells.This cutting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Self learning model for intelligent predictive control system for crystallization processes' (SINC-PRO) under Fifth Framework.

assistant: **Objectives**

Due to unpredictable crystallisation mechanisms, industrial crystallisation (up to 70% of all chemicals) is seldom operated under automatic control of product size distribution. This frequently results in non-reproducibility, unacceptable product qualities and excess energy consumption. Objective of SINC-PRO is to increase efficiency (reproducibility) and effectiveness (-20% energy, -5% cost, reduced time-to-market) by developing advanced techniques for on-line measurement and control. Results: flexible process modelling tool, observer/feedback system integrated with on-line measurement techniques, toolbox comprising of both Model Predictive Control and self-learning neural network type control. Exploitation: modelling and control tool box (two software developers), integrated modelling and control system with new measurement techniques (5 end-user industries), improved insight in crystallisation mechanisms and control (2 RTD institutes).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synergistic Advanced Carbon Capture Technologies for ConvERsion of Industrially Emitted CO2 to sustainable Production of biofuels and  chEmicals' (STEROPE).

assistant: **Concept**

STEROPE integrates advanced Carbon Capture and Utilisation (CCU) technologies with innovative conversion processes to establish a circular economy model. By leveraging cutting-edge membrane and catalytic systems, it enhances the efficiency and scalability of CO2 capture and conversion into renewable e-fuels under real-world conditions. The project targets significant GHG emissions reduction and fossil energy displacement, aligning with the EU’s climate neutrality goals through cost-effective CO2 valorisation, green hydrogen integration, and energy optimisation.STEROPE demonstrates industrial symbiosis by deploying its prototype system within a refinery, enabling resource sharing and reuse. The project advances CCU technologies to deliver a first-of-a-kind TRL 7 system capable of producing e-methanol, e-DME, and sustainable aviation fuels (e-jet), offering viable decarbonisation solutions for hard-to-abate industries.The initiative develops and integrates three CCU units, which will be installed and tested at the Eleusis refinery (Greece) as part of a demonstration plant. The DEMO including the three prototypes will be integrated into the regular operation activities of the refineryA digital twin approach will enhance operational efficiency and optimise renewable e-fuel production. To ensure market readiness, STEROPE includes end-use testing of e-methanol and e-jet for compliance with shipping and aviation sector requirements, guaranteeing performance, safety, and regulatory approval.A comprehensive LCA and TEA will evaluate environmental and economic feasibility, while stakeholder engagement will drive market adoption and policy alignment. By fostering industrial symbiosis and innovative business models, STEROPE accelerates the transition towards a circular, low-carbon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Electrochemical Bond Functionalization'.

assistant: **Innovation**

The impressive progress in organic chemistry during the past century has propelled this discipline to its current central position as the enabling technology in the physical and life sciences. Despite remarkable advances, our ability to assemble molecules of even moderate structural complexity remains unsatisfactory, since these syntheses continue to be inefficient, rely on a high number of reaction and purification steps, and generate undesired, often toxic waste. These features led to the general consensus on the need for greener chemical transformations that will stimulate the transition to more sustainable chemical industries.Conventional strategies in molecular syntheses make use of chemical redox reagents and directing groups, the installation of which results in costly reaction steps. Therefore, an environmentally-sound alternative is represented by molecular electrosynthesis to enable direct electro-functionalization of inert bonds. This strategy avoids prefunctionalizations, and prevents undesired waste formation, overall enabling a streamlining of organic synthesis for late-stage diversification.While significant recent progress has been achieved in electrosynthesis, available methods are limited, and key challenges remain, particularly metalla-electrocatalyzed transformations beyond the realm of innate reactivity are in high demand. I aim at addressing these major obstacles of selective electrochemical functionalizations. Thus, I will devise efficient electrochemical CH and CO2 functionalizations without directing groups, gain full selectivity control in molecular electrocatalysis, and achieve late-stage polymer and peptide diversifications. Establishing a comprehensive set of sustainable strategies for organic electrocatalysis, including paired electrolysis,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modular microelectronic system design' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The prime objective of the Modular MicroElectronic-Systems Design (MODES) project, is the establishment of a commercially viable route (The ModesRoute), with tools and methods, to support a whole-ist approach to development of cost and performance optimised MicroElectronic-Systems; minimising Time-To-Market, development cost and total development effort.To achieve this goal, MODES will address :- MicroElectronic-System Requirement Analysis and Hardware / Software Partitioning. - Microcontroller and system, design and debug cycles, maximising reuse of cells and design methodology (ELI). - Automated configuration of Real-Time Operating System (RTOS) recognising hardware resources and application requirements. - Application software development and debug, maximising reuse of high and low level software modules (SLI), language and debug tools. - Concurrent development support, providing development of application software in parallel with microcontroller availability. - Graphical Application Software Development techniques. ... and will culminate in the development of an Advanced Building Management System Controller, a MicroElectronic-system, using the ModesRoute developed in the project. MODES comprises three commercially strong yet complementary Partners, supported by three complementary academic and SME Associates, to provide the overall experience and new ideas needed to bring the project to a successful completion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Through-wafer connection for Integrated Optic devices for iMproved assembly and packaging to manufacture microsystems' (TIOM) under Fifth Framework.

assistant: **Objectives**

A major problem in the take-up of microsystems is the assembly and packaging strategy to be used. No standard methodologies exist for assembly and packaging for silicon based sensor/actuators, due to the incompatibility of the application of the sensor/actuator with standard IC applications. Separation of the electrical contacts and the active area of the device would enable the application of more conventional IC assembly and packaging technologies, reducing costs and increase reliability. The goal of this trial is to combine integrated optics technology developed by Lion Photonix with Hymite's technology, to create electrical contacts on the back side of the chip. The combination of these technologies will enable easy assembly, reduce costs, especially for multi-channel devices such as multispecies sensors as well as telecom components such as OADM's and optical switches. In order to demonstrate the technology demonstrators will be made of an optical sensor and an OADM (optical add/drop multiplexer).Objectives:The main objective of this project is to provide integrated optics technologies, with back-side contacts for easy assembly and packaging. The application of the technology will be demonstrated for two devices: optical sensor and an OADM. Once the technology has been proven successful, it is expected that it can also be widely used for other microsystems technologies.Work description:The integrated optics technology of Lion Photonix has a large potential for sensors and telecom components. However, to optimally use the properties of this technology, adequate assembly and packaging schemes have to be available to ensure a quick up-take of the technology by the European Industry. Recently, a method is developed by Hymite to create feed-throughs in a silicon chip to