RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'TREATMENT OF NON-HODGKIN S LYMPHOMA USING ALPHA-RADIOIMMUNOTHERAPY'.

assistant: **Objectives**

The main objective of this project is the demonstration on a European and worldwide level of the required steps to prepare a new drug for the therapeutical treatment of cancer based on alpharadioimmunotherapy. The products, techniques and installations to be validated are situated in the frame of blood borne cancer treatment both when applying autologous bone marrow transplantation (ABMT) or haematopoietic stem cell rescue (HSCR) ex-corpore and when treating minimal residual disease (MRD) in-vivo. Alpha-emitting nuclides and their daughter products will be used because of their favourable characteristics for the subject application (high linear energy transfer and therefore good cancer cell killing efficiency, short range and therefore minimal healthy cell killing). The short half-life of the alpha-emitting nuclide 213 Bi (45.6 minutes) also minimises the residual radioactivity both for the ex-corpore and the in-vivo treatment. The selection of B-cell malignancies for the demonstration of this innovative cancer therapy is based on the fact that blood and/or bone marrow borne cancers are the prime candidates to search for new purging techniques ex-corpore to reduce the residual cancer cell burden and the fact that they are ideally suited for alpha-immunotherapeutical treatment (e.g. for minimal residual disease) in-vivo using short lived radioisotopes. Non-Hodgkin's Lymphoma (NHL) was selected based on the finding that most patients with advanced-stage follicular lymphoma cannot be cured with conventional cytotoxic therapy and that the presence of minimal residual disease in bone marrow is a negative prognostic factor. For NHL the CD22, CD19 and CD20 antigen selective antibodies are well documented and some were tested already in their coupling to iodine or yttrium isoto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of hypothalamic thyroid hormone in the neuroendocrine regulation of appetite, energy balance and glucose homeostasis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Obesity is a global epidemic. The number of people who are obese or overweight increases annually. Being obese or overweight significantly increases the risk of co-morbidities that are currently amongst the major health problems of modern times, including diabetes and cardiovascular disease, collectively known as the metabolic syndrome. Currently 2-7% of European healthcare budgets are consumed addressing health problems arising from excess body weight, and this is predicted to increase. Body weight regulation is complex. In order to find successful therapeutic interventions it is essential that we understand the molecular basis and mechanisms of appetite and energy balance regulation. For decades thyroid hormone deficiency has been known to cause obesity. It has been assumed that the principal cause of obesity by hypothyroidism is reduced energy expenditure in peripheral tissues. But there is now compelling evidence that thyroid hormone has a direct role in regulating neural mechanisms involved appetite and energy expenditure. The objectives of this project are 1. To show that T3 chronically released in the hypothalamus of the rat causes increased food intake, body weight with potential to develop into metabolic syndrome. 2. To identify thyroid hormone-regulated genes involved in hypothalamic control of appetite and energy balance. These objectives will be met by using state-of-the-art approaches including brain implant technology and microarray analysis of hypothalamic gene expression. The work will be carried out at the University of Aberdeen Rowett Institute of Health and Nutrition, an institute with a wealth of experience in nutrition research. The project is expected to provide significant new information on involvement and mechanism of thyroid hormone in appetite
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Investigating the role of KDM4 demethylases on extraembryonic lineage competency in mice and humans' (KICK), addressing dissemination and exploitation.

assistant: **Impact**

During the first two weeks of human development, the embryo will generate sequentially progenitors of the extraembryonic membranes that will form the supportive tissues of the embryo proper. Impairments of their development have been linked to pregnancy diseases such as preterm birth. Human embryonic cells differ from mice by their remarkable plasticity, which allows them to generate extraembryonic lineages during a protracted period of time. The mechanism extending human embryonic cells competency remains a mystery. Enzymes of the KDM4 family remove Histone 3 lysine 9 methylation, a major epigenetic barrier to lineage conversion. However, there is a dramatic lack of knowledge on the role of KDM4s during early embryonic development. In this project I will investigate the function of KDM4 demethylases and how they influence embryonic cell competency in humans and mice. Human embryonic stem cells (hESC) and derivatives can be used as models of embryonic counterparts and possess equivalent extraembryonic lineage competency. In addition, hESC can be made to self-assemble into more complex 3D embryo models. These models provide an exciting and more accessible alternative to human embryos. In this project, I will leverage the combined expertises of the host lab and myself in embryology and stem cell based models to chart for the first time the localization of KDM4 demethylases and perturbate their expression with cutting edge CRISPR-dCAS9 technologies in models of human early development. Both myself and the host’s previous works have shown that the manipulation of chromatin regulators can be harnessed to break epigenetic barriers. I will thus use the overexpression of KDM4 demethylases to also enhance mouse embryonic cells competency. Elucidating how human embryonic cells re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulating the Mitochondrial Decision to Die' (REMITODED) targeting Seventh Framework.

assistant: **Abstract**

The mitochondrial pathway of apoptosis is the major form of programmed cell death in vertebrates. In this pathway, pro-apoptotic members of the Bcl-2 protein family cause mitochondrial outer membrane permeabilisation (MOMP) leading to the release of mitochondrial intermembrane space proteins that activate caspase proteases and apoptosis. Regulation of MOMP has been intensively investigated because it represents a crucial, and potentially targetable, process that determines cell survival.Upon initiation, MOMP has previously been shown to occur synchronously and quickly in all mitochondria in less than ten minutes. However, using a new approach that mimics cancer cells that are primed to die, I find that the duration of MOMP can take over one hour in some cells (termed here slow MOMP). Importantly, cells that undergo slow MOMP fail to display overt signs of caspase activity and survive in the short-term, strongly indicating that caspase activity and kinetics of MOMP are tightly linked. My first objectives are to understand what controls differential MOMP kinetics and define how these regulate caspase activity and cell survival.Furthermore, I have recently found that some mitochondria can remain intact upon MOMP. This suggests that under normal or stressed conditions a minority of mitochondria can undergo MOMP without triggering apoptosis (termed here accidental MOMP). A second objective will be to investigate the occurrence of accidental MOMP and understand its impact upon caspase activity and cell viability. To meet both objectives I will use a variety of biochemical and cell biological methods including extensive and novel live-cell imaging techniques.This project will provide new insight into how MOMP and cell survival are regulated. It is expected that results and kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Conservation and management of Mediterranean freshwaters under climate change: An eco-evolutionary and socio-economic modelling framework' to be submitted under Seventh Framework.

assistant: **Abstract**

There is increasing acceptance of the existence of a bi-directionality that intertwines ecological and evolutionary dynamics on the short time scales most relevant to conservation and management. Climate change and anthropogenic pressures are key drivers and accelerators of the short-term dynamic feedbacks resulting from these bi-directional interactions. Consequently, understanding how rapid climate-driven evolutionary and adaptive processes can influence ecological dynamics is crucial for defining ecosystem conservation and management strategies under ongoing global change. This is particularly relevant in freshwater ecosystems, where the impacts of climate change on ecosystem functioning threaten the implementation of several environmental directives, conventions and protocols, especially the European Water Framework Directive (WFD). The researcher proposes to evaluate how climate change will affect eco-evolutionary dynamic feedbacks under different river basin management scenarios at multiple spatio-temporal scales, using Mediterranean brown trout as model system. This will serve as a basis to simulate the long-term dynamics of biological reference conditions, ecological thresholds, restoration targets, and system recovery trajectories of Mediterranean mountain trout rivers.The researcher will use an innovative multidisciplinary and interdisciplinary approach, combining (i) statistical modelling of spatio-temporal patterns of climatic events and anthropogenic disturbances, (ii), molecular genetics and (iii) individual-based and eco-evolutionary modelling, to generate new tools for the conservation and management of Mediterranean salmonid freshwater systems under the WFD. The project aims to synthesize and harmonize the links among socio-economy, ecosystem conservati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Fluid-Structure Interaction and Machine Leaning for Controlling Unruptured Intracranial Aneurysms'.

assistant: **Innovation**

Developing new capabilities to predict the risk of intracranial aneurysm rupture and to improve treatment outcomes in the follow-up of endovascular repair is of tremendous medical and societal interest, both to support decision-making and assessment of treatment options by medical doctors, and to improve the life quality and expectancy of patients.The proposal aims at identifying and characterizing novel flow-deviator stent devices through a high-fidelity computational framework that combines state-of-the-art numerical methods for fluid-structure interaction modeling (to accurately describe the mechanical exchanges between the blood flow, the surrounding vessel tissue, and the flow-deviator) and deep reinforcement learning algorithms (to identify and to invent a new stent concepts enabling patient-specific treatment via accurate adjustment of the functional parameters in the implanted state). This has never been done before in this context and should thus open both new theoretical and numerical opportunities.CURE takes the vital steps of bringing novel computational and optimization frameworks to the next level capable of studying the selected flow diverter treatment in order to reduce the risk of hemorrhage in cerebral aneurysms, of supporting the decisions of treatment options by medical doctors and finally of providing guidance in the development of new implant design. Such unique capabilities can save millions of lives worldwide, improve the life quality of patients, eliminate lifelong side-effects due to sub-optimal treatment planning and delivery; and reduce the tremendous societal and economic burden linked to poor patient outcome.The proposed work has potential to reshape the future of intracranial aneurysm risk management. It is highly multidisciplinary, and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An Integrated Art Analysis and Navigation Environment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

European museums and galleries are culturally rich but public access has not reached its full potential. Digital multimedia can address these issues and expand the accessible collections. However, there is a lack of systems and techniques for the professional to provide access to citizens. The objectives of the project are to research, develop and demonstrate an integrated art analysis and navigation environment. The target end users are researchers, historians, publishers and course content creators for the fine arts. The project will research and develop advanced image content analysis algorithms, automatic indexing through metadata generation, distributed access to multiple collections and advanced navigation methods. Results will be: a fully integrated prototype analysis environment; recommendations for exploiting the project solution by European museums and galleries; and recommendations for exploiting the technology in other sectors.DESCRIPTION OF WORKThe partners will:* research and develop advanced image content analysis techniques for digitised works of art;* develop techniques to automatically categorise art works using these algorithms;* develop metadata representations for image categorisation;* develop seamless distributed access to multiple collections;* develop distributed content-based navigation methods for art collections;* build a robust and scalable integrated environment that incorporates the above components using an object-relational database;* develop a report on the impact on standards detailing augmentations of Z39.50 with RDF* establish business models that give the content owners direct control over the distributed representation, access and exploitation of digital multimedia content and metadata;* identify how the technical systems developed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neural bases of visually guided walking in the fly' (SensorimotorFly), addressing dissemination and exploitation.

assistant: **Impact**

Knowing how to get to a food source, approximate towards conspecifics or avoid a predator, are orientation behaviours with remarkable consequence for the success of an individual and the fitness of the species. They all depend on the brain’s ability to process sensory stimuli and integrate this with ongoing behaviour to generate spatial information that guides actions. Although much is known about how sensory neurons process incoming stimuli, or how motor neurons generate movements, it remains unclear how other neurons in our brains represent more integrative processes that lead to the transformation of sensation into action.For visual animals, visually guided locomotion is an ethologically relevant behaviour that is easy to reproduce in a laboratory environment, and depends on the integration of visual motion signals with ongoing locomotion. Through the identification of interconnected neurons, and analysis of their activity patterns in simultaneous with quantitative measurements of visually guided locomotion, we aim to determine the functional organization of visuomotor circuits essential to orientation behaviours. In particular, we would like to understand how self-generated motion vision provides information to guide the animal’s orientation behaviours.To transcend the experimental limitations found in mammalian model systems, such as the numerical complexity of their brains, or the more limited resources available to systematically identify and perturb neurons of a circuit, we employ the fruitfly, Drosophila melanogaster, as our model organism. Her rich repertoire of visually guided behaviours combined with her unparalleled arsenal of genetic tools, and with head-fixed physiology in behaving animals, provide an ideal platform for a multilevel research program to st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Fluidic Shaping of Optical Components on Earth and in Space'.

assistant: **Innovation**

We propose to develop and demonstrate a new concept that leverages the fundamental physics of interfacial phenomena to rapidly fabricate complex optical components of any size (from millimeters to meters) with sub-nanometer surface roughness, without the need for any mechanical processing such as grinding or polishing. We term our approach ‘Fluidic Shaping’ to describe its core principle – the ability to take a volume of liquid, shape it into a desired form, and finally cure it to obtain a solid object. The method relies on negating gravitational forces that act on the liquid, which we achieve on Earth using buoyancy forces, and which can be naturally achieved in space flight. By dictating the boundary conditions of the liquid, we vary the minimum energy state of the system, and drive the liquid interface into a desired shape. The proposed project is composed of five main aims: (1) development of a theoretical framework that would describe the range of optical surfaces that could be produced and provide engineering guidelines for the rest of the project, (2) development of a stand-alone device for fabrication of high quality corrective lenses, (3) development of methods for fabrication of high precision optics, and expansion of the range of materials that could be used, (4) demonstration of in-space manufacturing of optical components, and (5) development of approaches for deployment of very large (meters) fluidic lenses. These aims serve to put in place the basic and foundational knowledge that could enable transformative changes in multiple fields: (a) rapid prototyping of optical components – by enabling fabrication of custom, high precision optics in minutes, (b) access to corrective eyewear in low resource settings – by enabling fabrication of quality lenses withou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dissecting a stepwise principle of cellular diversification to instruct regeneration in the enteric nervous system' in the context of a Horizon Europe call.

assistant: **Objectives**

The enteric nervous system (ENS) contains a large range of neural subtypes that collectively controls essential gut functions independently of the central nervous system (CNS). Although the ENS is capable of forming new neurons following injury or inflammation, it fails to regenerate completely. My lab recently established a molecular classification of enteric neurons and discovered that they diversify through a conceptually new principle during development. Only two neuronal identities form during neurogenesis while all other classes emerge through subsequent differentiation at the postmitotic stage. This stepwise conversion process contrasts from the better understood CNS development where spatial patterning of stem cells predominates cell fate decisions. Dissecting the molecular basis for the sequential acquisition of cell identities in the ENS will advance our fundamental understanding of cell heterogeneity emergence. In divENSify we propose to push new frontiers in neuronal identity formation to facilitate constructive regeneration in the adult gut. Combining single cell RNA and chromatin profiling we will assess the role of pioneering transcription factors and competent cell states in each step of differentiation. We will dissect gene regulatory networks and identify key determinants using ultrasound-guided gene manipulation, a novel method we recently developed to target the otherwise inaccessible ENS in utero. We will determine how injury-induced adult neurogenesis correlates with developmental paradigms and leverage knowledge on latent potentials and intrinsic transcriptional regulators to engineer specific neuron types through viral gene manipulation in the adult gut. The proposed project will transform our comprehension of neuron identity formation and mainte