RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Xtend U – An Amputee solution for a life without pain, blisters and infections' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Xtend U is a prosthetic liner developed to help ventilate the stump while fulfilling the primary role of a liner. Unlike traditional liners, it is made of 3 layers. The first layer is a compression sock in direct contact with the skin. It is made of an ultra-breathable textile and has friction increasing dots that further support the suspension to the stump. The second layer is a washable super-absorbent material that can absorb up to 1000% of its weight in water without significant volume change. Finally, the third layer allows for securing the liner to the prosthetic, protects the inner layers and helps transmit loads from the prosthetic.This combination of materials enables reducing by half the relative humidity around the stump. This will make a massive difference for users that will get a cooler feeling and reduced risk of chafing, blisters, sores and infections. Xtend U will provide crucial comfort allowing prosthetic users to wear their prosthetics for extended periods of time.


**Keywords:** prosthetics,absorption,perspiration,textiles,smart textiles,biomechanic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Experimental investigation of physico-chemical effects of low-energy electron interaction with isolated, clustered and self-assembled biomolecules' to be submitted under Seventh Framework.

assistant: **Abstract**

The proposed study will focus on effects of low-energy electron interaction with isolated amino acids and short peptides deposited on lipid bilayers mimicking the cellular membrane, as well as on oligonucleotides and on DNA. Owing to the simple structure of phospholipids, they present a geometrically and physico-chemically well-defined biomolecular array and potentially an ideal matrix for homogenous distribution of amino-acids, nucleotides, DNA, and RNA chains, with or without presence of water. By finding the probability for the temporary electron attachment to amino acids, oligonucleotides and DNA molecules and observing and quantifying the effects of vibrational and/or electronic excitation when molecules are combined into more complex structure, the proposed research will be advancing the knowledge in Physics, Chemistry and Biology and will be relevant for nanotechnology in their quest for new materials and creation of electronic molecular devices. The analysis of damage products (radicals) from the interaction of electrons and ion radicals with short oligonucleotides and DNA deposited on lipid films in the presence of specific amino acids will be performed aiming to possibly tracking the path of proton transfer and oxygen radical in the substrate after irradiation by electrons. An important aspect of the proposed research is investigation of the role of water in the processes of resonance formation and fragmentation of lipids and other biomolecules deposited on a lipid substrate. Measurements will be performed using several experimental techniques: Electron Energy Loss spectroscopy (Time-of-Flight measurements of the spatial and temporal distribution of electrons reflected from the sample and transmitted current measurements), X-ray Photoelectron Spectroscopy (usi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improving the crashworthiness of composite transportation structures' under Horizon 2020.

assistant: **Concept**

The European aerospace, automotive, and rail industries are committed to improving their energy efficiency to meet targets set within the EU’s climate, energy and transport policies. This is motivating the increased use of lightweight composite materials in lieu of heavier metallics. To implement this transition, these industries must reach, at least, the same level of crash performance achieved with metals, but at significantly lower weight and without increasing cost. This is viewed by industry as an exceptionally challenging goal and will require highly trained engineers, versed in the myriad aspects of designing cost-effective, crashworthy composites structures, and capable of harnessing the latest research developments in the fast-changing world of composites. The ICONIC ETN aims to cultivate such a new generation of young engineers; comfortable and fluent in the integration and exploitation of knowledge from fields as diverse as materials science, chemistry, computational methods, solid and damage mechanics, textile technology, structural design and optimisation. These researchers will acquire the skills to enable the sustainable and economically-viable design of a new generation of highly efficient, lightweight transportation composite structures that will provide the maximum protection to occupants through superior crashworthiness. 15 Early Stage Researchers (ESRs) will be recruited to take up posts, across the UK, Ireland, Greece, Germany, Italy and Sweden, in an innovative, multidisciplinary and intersectoral structured research and training programme.  ICONIC is supported by a strong consortium from academia, large industrial enterprises and innovative SMEs. A comprehensive training and secondment programme (including joint supervision and industrial mentorin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving the production of the anti-malarial artemisinin in artemisia annua', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Artemisinin and its derivatives are a very promising new group of drugs against malaria. A biotechnological approach, including cloning and heterologous expression of the genes involved in its biosynthesis, will be employed in order to improve its production in Amanda plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Virtual experimental toolbox for 3D/4D recrystallization' in the context of a Horizon 2020 call.

assistant: **Objectives**

Although microstructural characterization techniques are advancing, they are still inadequate to explain the complex behavior of recrystallization: Unexpected local grain boundary migration may relate to local variations in the deformation microstructure, but 3D quantification is needed. Newer studies suggest that residual stress may affect the boundary migration, but consensus is lacking. Additive manufacturing is becoming popular. Here the formation of pores/voids are observed but their effect on boundary migration is totally unexplored.  Various processes and materials parameters are coupled and acting simultaneously, their individual effects cannot be separated experimentally. A novel paradigm is required to quantify the above-mentioned new and critical aspects with the larger longer-term goal to improve properties and design novel materials. I want to show that a virtual experimental toolbox for 3D/4D recrystallization is the way forward to remove the bottleneck. In this toolbox, for the first time ever, quantitative phase-field simulations will be directly coupled with 4D X-ray Microscopy (4DXRM) experimental data.  The necessary steps to achieve my goals:1)Develop expertise in 4DXRM and learn to design the critical experimental studies (supervisor is expert).2)Develop quantitative 3D phase-field models to capture complex behavior of recrystallization and implementation it in MOOSE Framework software for large-scale simulations (PI is expert)3)Coupling of 4DXRM data with MOOSE Framework (in collaboration).The vision is that the newly developed virtual experimental toolbox can be used by experimentalists and scientists in industry with minimal training. This fellowship is going to make me a unique expert in the field of phase-field model development and experienced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Evolution of Wing Coloration in Lepidoptera', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The seemingly endless diversity of color patterns in the wings of Lepidoptera (butterflies and moths) is both a marvel and an enigma. On the one hand, it has been long known that the function of color patterns is visual communication, such as sexual signaling and predator deterrence. On the other hand, the fairly recent discovery that color patterns are determined by only a handful of genetic loci and associated regulatory elements, apparent constraints to diversification. The EWINCOL project will reconcile ecological function and variation of the developmental template to provide a deeper understanding of the relationship between the immense phenotypic and taxonomic diversity within the Lepidoptera that we see today. I posit that wing coloration has facilitated evolutionary diversification in Lepidoptera by being both genetically and developmentally conserved but evolutionarily labile, repeatedly generating variation that fuels selection.  With the help of an ERC starting grant I will test this hypothesis by implementing a research program that will make innovative use of natural history museum collections and online citizen science platforms. First, I will leverage phenotypic information from large public image databases by using cutting edge artificial intelligence (AI) methods to create a comprehensive database of coloration and shape traits of all major Lineages within Lepidoptera. This database will then allow me to i) map out the evolutionary history of coloration in Lepidoptera and test how variation in coloration relates to diversification in a phylogenetic context, ii) investigate to which degree the evolution of coloration and wing morphology are independent from one another, and iii) ascertain the role of environmental factors like habitat, light and tempera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Asymmetric carbyne catalytic transfer to streamline synthesis of chiral β-amino carbonyls' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The chiral β-amino carbonyl is an important structural motif prevalent in natural products and therapeutic agents. Despite that many methodologies have been developed for their diastero- and enantioselective synthesis, most of these methods require multistep manipulations with pre-functionalized substrates that fail to introduce the β-amino carbonyl moiety at the late-stage of complex molecule synthesis. Chiral-Beta aims to develop an innovative technology to rapidly construct chiral β-amino carbonyl derivatives with feedstock and fine alkenes as well as with complex drug molecules/natural products based on a Rh-catalyzed asymmetric carbyne transfer platform. A key strength of this conceptually new and multidisciplinary proposal is the introduction of a secondment phase in Novartis (Basel) to explore real-life applications. The ambitious action merges perfectly the expertise of the host in novel C-H and C–C bond functionalization strategies based on the catalytic generation of carbyne equivalents with the strong background of the applicant in metal-catalyzed asymmetric reactions, thus enhancing two-way transfer of knowledge between the ER and the host group. This project will expose the fellow to a wide range of cutting-edge chemistry and biomedical sciences in an interdisciplinary and international environment (ICIQ, Novartis) and enable the fellow to become a leader for the next generation in the field of chemical synthesis and late-stage functionalization techniques.


**Keywords:** Rh-carbenes, hypervalent iodine reagents, C-C bond cleavage, amination, beta amino carbonyls
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Testing, Monitoring and Analysing the performance of mobile neTworks for the connEctivity requirements of IT-solutions pertaining to freight and public transport as well as autonomous driving'.

assistant: **Concept**

Many European countries face difficulties meeting the increasing demand from private and commercial users and local authorities for a mobile connectivity available especially in rural areas and in constrained areas such as indoor locations, subways, tunnels and hot spots. The Europe 2020 strategy seeks to ensure that by 2020 all Europeans should have access to much higher internet speeds of above 30 Mbit/s and at least 50% or more of European households subscribe to internet access above 100 Mbit/s. Now that the Europe 2020 strategy has approached the end of its life cycle, it is time to check that the targets have been met regarding the quality of mobile networks: Thus, the applicant ENQT GmbH plans to test and analyse the performance of mobile networks for the connectivity requirements of IT-solutions pertaining to freight and public transport as well as autonomous driving. For these purposes, more and more devices are connected to the internet via mobile networks. Continuous availability to mobile networks and a reliable data transfer are critical success factors for many digital projects.  ENQT is a prosperous startup offering innovative technology solutions and comprehensive consulting services related to IoT and Industry 4.0, currently especially for energy and heating use. As part of the internal innovation strategy ENQT plans to widen the focus to other economic sectors. The strategic objective of the project “TMate” is to obtain location-based data on the mobile network quality (signal strength, data transmission rate) in a smart way using methods of intelligent measurement technology. Recruiting an Innovation Associate will help ENQT to gain essential know-how in the fields of commercial applications, statistical time series analysis in order to reveal the ful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'RET Trafficking' (RET-TRAF) under Horizon 2020.

assistant: **Objectives**

Protein kinases play a critical role in a number of cellular processes, including cell proliferation, differentiation and apoptosis. The REarranged during Transfection (RET) receptor tyrosine kinase plays important roles in regulating cellular proliferation, migration, and survival in the normal development of neural crest derived tissues. Furthermore, aberrant activation of RET, through oncogenic mutations or overexpression, can contribute to tumourigenesis, regional invasion, and metastasis of several human cancers. RET relocalisation plays a role in cancer invasion and metastasis. Unfortunately, the detailed understanding of RET's dynamic function and the importance of quantitative, spatial and time-dependent parameters regarding RET trafficking is lacking. As such, the ability to manipulate RET activity using light would result in temporal control of enzymatic activity, thus serving as a valuable approach to probe the RET trafficking, further our understanding of cell movement and invasion. Cells will be exposed to photoresponsive RET inhibitors that can be turned on and off with light. Their effects on RET trafficking will be monitored by imaging. The results of these studies will provide new insights into intracellular RET trafficking and its role in cancer, ultimately leading to new therapeutic targets and improved disease management.


**Keywords:** Protein kinases, REarranged during Transfection, oncogenic mutations, RET trafficking, photoresponsive RET inhibitors, therapeutic targets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advances in FOrestry Control and aUtomation Systems in Europe' under Seventh Framework.

assistant: **Concept**

The forest-based value chains are one of the dominant contributors to the GDP in the rural regions of Europe. Besides the traditional value chains, novel ones are in the horizon, with significant impacts on the requirements for the raw material supply chains. A major roadblock for improving forest-based value chains is the lack of integrated control and planning mechanism. FOCUS will demonstrate how innovative sensor technologies and control methods can solve this problem, with case studies in Finland, Belgium, Switzerland,Germany,Austria, Portugal covering the main forest-based production processes in Europe – biomass for bioenergy, timber and pulp wood, and cork transformation.The goal of FOCUS is to improve the individual value chain processes, and to remove the barriers for integrated planning and control for the whole value chain. The project brings together leading SMEs and organisations in the fields of environment and machine sensors, production machinery and control automation software development.  The expertise is needed to address the key challenges: novel sensor development for environment, raw material and production machinery monitoring; new process specific control processes; plug-and-play composition of value chain wide control processes.The productivity and sustainability of the value chains will be enhanced by enabling the best use of the production resources, and by reducing harmful impacts like soil compaction by forest machines, and carbon footprint of the operations. Product marketability will be increased by traceability of raw material origin, and by controlling the quality of the raw material during the production process. The open source FOCUS platform will foster new business models by enabling several SMEs to jointly offer solutions. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Foldamers against protein-protein interactions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Foldappi proposal aims to investigate the potential of aromatic amide Foldamers to disrupt protein-protein interactions. The scientific goals of the project include:  1. development of synthetic methods to build foldamers with different R-group chemistries 2. development of strategies to target foldamers to protein surfaces 3. measuring in vitro properties of foldamer(s) to assess ADME profiles of these molecules  In this proposal we propose to explore the use of quinoline-derived aromatic amide foldamers developed at the University of Bordeaux to inhibit protein-protein interactions, namely the interaction between interleukin 4 (IL-4) and its receptor.  These foldamers have a very well defined structure that lends itself to the rational design of substituents and the production of focused combinatorial libraries of foldamers capable of interacting with the IL4/IL-4R binding epitope. They are also large enough to block a protein-protein interaction, a feat that is not possible with small molecules. The cytokine IL-4 is a key regulator of the immune system determining the formation of immune cells and immunoglobulin class switching. IL-4 is critically involved in misguided immune reactions during atopic diseases as allergy and asthma. In spite of its importance as a drug target, no small molecule inhibitor of the Il-4/IL-4R has been reported so far, warranting the use of foldamers to do the same. The three partners involved in this cooperation, namely UCB Pharma, Université Bordeaux I and Universität Würzburg each have unique expertises necessary to bring this project to completion. This combination will produce breakthrough knowledge and insights into developing chemistries that can impact in health and medical fields. Moreover, this project will contribute to the p