RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Precision study of W bosons pair production in association with jets at High Energy Colliders' in the context of a Seventh Framework call.

assistant: **Objectives**

With the beginning of the experimental programs at the LHC, the need to describe multi-particle scattering events with high accuracy has become more pressing. On the theoretical side, perturbative calculation within leading order precision cannot be sufficient, therefore accounting for effects due to Next-to-Leading Order (NLO) corrections becomes mandatory.In the last few years, tremendous progress in the computation of one-loop virtual corrections for processes involving many particles has been observed. The new ideas based on the universal four-dimensional decomposition for the numerator of the integrand for any one-loop scattering amplitudes, the four-dimensional unitarity-cuts, detecting only the (poly)logarithmic structure of the amplitude, known as the cut-constructible part, and unitarity-cuts in $d$-dimension, yielding the complete determination of dimensionally regulated one-loop amplitudes, appear to give the possibility of developing an automated multi-process evaluator for scattering amplitudes at NLO. In this context, the researcher and his collaborators merged many of the new ideas to develop a new formalism encoded in a public computer program called SAMURAI. SAMURAI is a tool designed for the automated numerical evaluation of one-loop corrections to any scattering amplitudes within the dimensional-regularization scheme.The potential of SAMURAI will be exploited into all possible high energy physics applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unchaining diagnostic and therapeutic tools for syphilis in pregnancy, neurosyphilis and treatment failure.' in the context of a Horizon Europe call.

assistant: **Objectives**

For over 50 years, the tools for diagnosing, preventing, and treating syphilis have seen minimal progress, partly due to limitations in bacterial cultivation. Existing tools were primarily drawn from research on early-stage syphilis and evidence extrapolated to severe forms of the infection, leaving important unmet needs like the lack of predictive markers for neurosyphilis and mother-to-child-transmission, limited evidence on treatments for these conditions, and challenges in monitoring treatment failure. This project aims to shift the paradigm by demonstrating that the diverse manifestations of syphilis are not merely random infections in different bodily compartments but are intricately linked to unique bacterial traits and host responses that necessitate specific tools. Our goal is to discover manifestation-specific biomarkers, repurpose antibiotics for tailored treatments, and pioneering TPA isolation methods for treatment monitoring. Taking advantage of a unique network of collaborators in areas with a high incidence of severe syphilis, I will examine how severe clinical manifestations relate to genomic variations in TPA strains and with host humoral responses. A groundbreaking pan-proteomic array will allow identifying markers linked to clinical phenotypes and it will open avenues for discovery of new antigens as vaccine candidates. Furthermore, I will exploit the established expertise of my team on drug repurposing and conducting randomized clinical trials to evaluate the efficacy of alternative antibiotics to cure patients with neurosyphilis and syphilis in pregnancy. Finally, I aim to pioneer methods for the first-time isolation of TPA from patient samples and conduct antimicrobial resistance testing in treatment failures. The resulting tools will be a tremend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular basis of neurodegeneration in transmissible spongiform encephalopathies (prp and neurodegeneration)' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The recent apparition of BSE and cud in Europe has raised tremendously the public interest in health and consumer protection" with regard to food and to other derived products susceptible to carrying the infectious agent of these diseases. This proposal will focus on the mechanisms of neurodegeneration in Tees and in particular on the relationship between Prep expression, metal ion metabolism and oxidative stress. The role of two additional pathogenic factors, a transmembraneform of Prep and Doppler, a Prep related protein, will also be considered. Experimental approaches will include cellular and animal models of Tees and state of the art techniques in oxidative stress and signal transudation analysis. We believe that advances in the knowledge of the Prep physiological and pathological function, as well as in the mechanisms of neurodegeneration in Tees will provide the basis to new preventive and/or therapeutic strategies against these diseases."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '1D magnetic nanostructures using mineralizing peptides' to be submitted under Seventh Framework.

assistant: **Abstract**

Magnetite nanotubes are interesting for numerous applications including MRI, Biological and molecular separation, arsenic removal and catalysis of ammonia synthesis. The goal of this project is thus to create magnetic peptidic nanotubes using a bottom-up approach. A self-assembled peptidic nanotube template will be used to nucleate or attach magnetite nanoparticles on its inner and / or outer surface. The peptides will be selected for their ability to self-assemble in water and potential to mineralize magnetite or silica on their surface.The magnetite nanoparticles (Fe3O4) will be formed by oxydation of Fe(II) precursors onto the peptide surface or extracted from magnetotactic bacteria and bound onto the tube surface. We will also mineralize an additional silica layer in order to create triple-layered nanotubes (magnetite-peptide-silica or peptide-magnetite-silica) to improve the resilience and biocompatibility of these nanotubes. If necessary, the peptidic part will be removed through heating at high temperature (600°C).  The resulting objects will be studied using SAXS, TEM, optical microscopy, Mössbauer spectroscopy.This study will help to gain insight on the biomineralization mechanisms used by magnetotactic bacteria to control the precipitation of magnetite chains in their cytoplasm.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CITIZENS ADVISORY SYSTEM BASED ON TELEMATICS FOR COMMUNICATION AND HEALTH' under Fourth Framework.

assistant: **Concept**

CATCH aims to exploit advanced multimedia technologies in a novel information service on health matters for everyone. It will enable virtually all groups, including elderly and handicapped people, to take preventive action against ill-health, understand symptoms, and generally assume responsibility for their own well-being. Besides pointing the way to the right treatment, the system will also assist personal decision-making in the area of health insurance. The project will result in a multilingual advisory service for use anywhere and at all times.The aim of CATCH is the widespread implementation of health sources for every European citizen at any time and any place with the use of modern advanced information and communication technologies for:- background information in preventive health- offer data-based and knowledge based facilities to make the citizens aware and give them directions and opportunities to make independent decisions about his own (preventive) health- give the opportunity to every European citizen to become informed about differences in (preventive) - health throughout Europe and take decisions about treatment, insurances.The result of the project will be the multimedia multilingual citizens advisory system (M2-BBS), a European tool that will be highly effective and efficient:- it can be used any time at any place- it is multifunctional using multimedia, such as text, pictures, videos- it is accessible for many groups: elderly, handicapped, minorities, youngsters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Complex parasite communities as drivers of bacterial immunity' (PHAGECOM) targeting Horizon 2020.

assistant: **Abstract**

CRISPR-Cas is one of several distinct bacterial defence mechanisms that provide immunity against viruses (phages) and other mobile genetic elements (MGEs; e.g. plasmids). My research aims at understanding how CRISPR-Cas-mediated immunity is affected by the complexity of MGE communities. Using evolution assays and deep sequencing techniques I aim to study (i) the evolution of CRISPR-Cas-mediated immunity in a complex MGE community (i.e. multiple phages and plasmids), and (ii) determine the associated co-evolutionary dynamics. The proposed research is highly multidisciplinary and will perfectly complement my background in biochemistry and molecular biology. It also allows me to establish collaborations with academic and industrial partners to realize applications in dairy industry and phage therapy. The project will be pivotal for my personal development to become an independent researcher and offers me the unique opportunity to work in one of the most prominent microbial ecology and evolution laboratories worldwide, based at the Biosciences Department at the University of Exeter. Biosciences is a leading institute in evolutionary biology, microbiology and ecology that provides excellent opportunities for academic training and personal career development. I will be exposed to novel ideas and input from renowned researchers belonging to scientific disciplines unrelated to my own background, offering exciting opportunities for knowledge exchange and will have a strong impact on my personal and scientific development. Furthermore, I aim to establish a series of lectures for the general public throughout 2015 (the Year of the Phage) to emphasize the importance of phage research for many aspects of our society, including industry and medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Empowering Radiologists in Cancer Diagnostics with Artificial Intelligence' under Horizon Europe.

assistant: **Concept**

There is already a major shortage of radiologists who analyse CT scans for cancer diagnostics. Radiologists spend too much time on manual and repetitive tasks, such as manually measuring lesions, using inadequate tooling. As the incidence of cancer is expected to grow 27.4% over the next 10 years (according to WHO), the pressure on radiologists will only increase, leading to misdiagnosis or delay in diagnosis with potentially fatal consequences.With Better Medicine Artificial Intelligence, the time radiologists spend on interpreting cancer-related CT scans is reduced by 40-60% by automating a range of repetitive tasks to significantly streamline workflows. We help reduce the shortage of radiologists, while saving lives with timely and accurate diagnostics.Our solution is the first AI-powered tool for radiologists that takes the full-body approach and enables dynamic assessment of tumours, overcoming the biggest shortcomings of current offerings on the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MOdeling and Reduction of Aeroacoustics Sources of Interaction Noise in Aviation'.

assistant: **Objectives**

The target of climate-neutral aviation has led to a strong increase in the size of new propulsion systems, resulting in their lowered distance to the airframe components. This causes new aerodynamic interactions with heavy distortion of the turbulent flow, determining unpredictable sources of noise. Mitigating this interaction noise would allow to deploy radically new aircraft configurations capable of reducing up to 20% of the current aviation emissions.While studies from literature have tried to correct discrepancies larger than 10 dB from acoustic predictions by a-posteriori tuning the models to very specific flow patterns, recent results from my team have shed light on the physics behind the unpredictability of these noise sources. Results hinted that the geometrical deformation of the turbulent flow from its original pattern might explain the origin of interaction noise.To solve this puzzle, with MORASINA I aim at first understanding how the flow and the turbulence are distorted in archetypal interactions between rotating and stationary aerodynamic objects. My objective is to discover the unknown mathematical formulation to model this distortion mechanism and to use it to create the first holistic acoustic model for predictions of interaction noise.By innovatively describing the interaction mechanisms with mathematical functions related to the geometrical distortion of the flow, I will find an answer to whether different flow fields can be assimilated in a unique fundamental flow pattern. With this knowledge, I will create the first acoustic model based on a mathematical flow twin to accurately predict interaction noise.For maximum impact on the society, I will extend the model to equipollent interaction mechanisms with a neural network approach trained on the resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a gene therapy approach to the treatment of HIV infection and AIDS'.

assistant: **Objectives**

There are four basic objectives to the proposal:1. Development of new constructs which express antiviral genes directed against HIV.2. Demonstration of expression of these genes in eukaryotic cells. Stable and, where appropriate, inducible expression.3. Assessment of the ability of these antiviral genes to inhibit replication of HIV which has been introduced into these cells.4. Efficient delivery of such antiviral constructs, firstly to established the cell lines, secondly to primary human T-cells derived from peripheral blood, and thirdly to haemopoietic stem cells. These will be derived from CD34 cells from umbilical cord and bone marrow cell populations or from peripheral blood.A necessary accompaniment to these studies is that the delivery of such antiviral constructs should be performed in as safe a manner as possible. Thus, ensuring safety will be paramount during these experiments and in the gene therapeutics being developed.These objectives are similar to those currently being attempted by groups elsewhere, notably in the USA. Our grouping however has an unusual combination of expertise in the diverse areas of gene delivery and in HIV molecular biology. All the collaborators are experts within their fields. Whilst it is possible that commercially exploitable gene therapeutics will derive from this collaboration it is not certain there is an equivalent group in industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Earthquake simulator 6 dof and reaction wall' (ECOLEADER-ATH).

assistant: **Innovation**

Description:Our laboratory began operation 1986 and has as its focal point a 6 DOF earthquake simulator (shaking table) of 15 tonne capacity, a rigid platform of 4x4m2, a reaction wall 10 MNm capacity, 6m height and 4 and 5m long and other mainly innovative testing rigs. A 64 and 16 channels high-resolution data acquisition systems functioning. The Simulator has a system for controlling the motion and recording the response of specimen tested on it. Our Facility is mainly dealing with Earthquake Engineering and Structural Dynamics problems. It is functioning within a pure earthquake engineering and structural dynamics research environment.Application:Applicants with interest in earthquake Engineering should apply in writing to the DIRECTOR of the laboratory Prof. Panayotis Gr. CARYDIS.Project Manager:Panayotis Carydis, Department of Civil Engineering, Polytechnic Campus, Zografos/Athens 15700, GreeceTel: +30-1-77211 8580Fax: +30-1-7721182E-Mail: pcarydis@central.ntua.gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Generalised Time-Separated Stochastic Mechanics' (Gen-TSM).

assistant: **Innovation**

As a physical fact, randomness is an inherent and ineliminable aspect in all physical measurements and engineering production. Hence, all material parameters are subject to stochastic fluctuations. However, highly accurate predictions are key to achieving the goals of resource-efficiency and sustainability in engineering and construction. In this context, randomness in material parameters constitutes a severe problem: if we can experimentally quantify the magnitude of fluctuations of material parameters, how can we numerically include this information to predict fluctuations in the reactions of construction parts or processes?All existing strategies for the inclusion of stochasticity in engineering design share the drawback of large numerical costs, leading to inefficiencies, e.g., an increase in simulation time by orders of magnitude. This prevents their industrial application and, consequently, stochastic fluctuations are not factored into design. This is compensated for by adding buffers, e.g., overestimated safety factors, oversized wall thickness, or higher maintenance frequencies, all leading to increased economic and environmental costs.Thus, a step change in engineering design is required to allow the inclusion of stochasticity into material modelling and engineering simulation, while minimising the numerical extra cost. Gen-TSM aims to meet this challenge by developing a novel strategy for efficient stochastic modelling of highly complex problems and creating a computational framework for the automated formulation of stochastic versions of existing material models. My vision is to unlock the currently untapped potential of material modelling and enable computing stochastic behaviour to become the new standard in engineering design. This would revolutionise curr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative tools for offshore wind and DC grids'.

assistant: **Innovation**

Europe’s power system has seen significant changes in recent decades, notably the development of renewable energy sources. However, this transition is far from complete, and further changes are essential to make our energy system ready to play its part in realising the climate goals set at COP21. At present, renewable energy sources are increasing their share of electricity generation. This is particularly the case for offshore wind energy. InnoDC's 14 participants prepare 15 early career researchers to play their role in the energy transition that will take place over the next 20-40 years.The project focusses on the development of the electricity transmission system, targeting the connection of offshore wind, the integration of offshore wind with the existing power system (including the use of HVDC), and the operation of the future power system where large scale wind is connected to a hybrid AC and DC power system.Technological development for offshore wind is ongoing. This research project focusses on the models and methodologies for the integration of these new technologies (e.g. offshore wind turbines, VSC HVDC converters, long AC cables) into the power system. Challenges in these areas will be addressed in this project: firstly, these new devices behave inherently differently to traditional power system components. Secondly, the multi-actor/intersectoral nature of these systems means that they have distinct elements and devices interfacing with each other, each with limited information of the overall system.The project will train the researchers in developing prototype tools to aid the developers and users of these new energy systems.This training network aims to train the researchers of the future in the pivotal sector of renewable energy and grid technology, whic