RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Broadband Lightwave Sources and System' in the context of a Fourth Framework call.

assistant: **Objectives**

The main objective is to bring to full maturity key advanced components and modules for photonic networks and to demonstrate their practical use in systems. A large number of specific targets are set for component performance. Demonstration of practical applications will be carried out within the project as well as in other ACTS projects.The project expects to demonstrate improved component performance, improved scope for low cost manufacturing, as well as practical applications of advanced optical components.Among the results to date are:Worlds first monolithically integrated InP based reconfigurable add-drop multiplexerCompact low-loss polarisation insensitive phased array demultiplexerDevelopment of tuneable lasers with complete coverage of the 1550nm windowDemonstration of a wavelength programmable sourceDemonstration of 20Gbit/s all optical demultiplexing using a monolithically integrated non-linear Sagnac interferometerLaser flip-chip mounting for passive fibre alignment and high speed operationDefinition of a software environment and documentation structure for automated characterisation and parameter extraction, including options for remote characterisation.Monolithically integrated non-linear Sagnac interferometer for OTDM.Expected ImpactBy addressing improved functionality and cost-effectiveness for photonic modules, the project will assist in providing access to IBC networks for private and business users and aims to demonstrate the potential for high capacity services such as multimedia and video conferencing.Main contributions to the programme objectives:Main deliverablesA reference model for Interactive Satellite Broadcasting via SMATV installations and a demonstration of such a service.Contribution to the programmeDevelopment of inexpensive broadband acce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Systems Chemistry Approach towards Semiconductive Supramolecular Copolymers with Homo- and Heterometallophilic Interactions' (SUPRACOP), addressing dissemination and exploitation.

assistant: **Impact**

Infinite one-dimensional structures with a metallic main chain of short metal-metal contacts have attracted considerable attention in the field of materials science for many decades due to their excellent optical properties and remarkable dichroism and electrical (semi)conductivity. These materials suffer, however, from decomposition prior to melting and low solubility and processability. The strategy of introducing alkyl side chains of different nature in the past two decades proved to be particularly successful towards better soluble materials or gels with implications in optoelectronics. However, this comes at the price of reduced bulk conductivities leading in some cases to electrical insulators due to the perturbation of the metal-metal contacts.In this proposal, a Systems Chemistry approach will be introduced to create unprecedented supramolecular copolymers that are anticipated to exhibit: a) high solubility, reversibility and stability in organic solvents and water and, b) short metal contacts involving either positively and negatively charged metal ions of the same nature (Pt2+/Pt2-) or dissimilar metal centres (Pd(II)/Pt(II) and Ag(I)/Au(I)) with equivalent coordination geometry. To achieve this goal, ligands with an extended aromatic surface for pi-stacking supported by complementary non-covalent interactions have been selected to bring suitable metal ions in close proximity. This can be summarized in three approaches. 1) Optimization of the geometrical complementarity between the interacting ligands; 2) Introduction of hydrogen bonding and electrostatic complementarity between side groups, and 3) Exploiting weak interactions between geometrically equivalent electron rich and electron poor units. The extent of metal-metal interactions can be ultimately contro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular control of surface expression of the transferrin receptor in the bloodstream form of trypanosoma brucei' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The African trypanosome Trypanosoma brucei can multiply for years in the bloodstream of mammalian hosts. The growth of bloodstream form (BF) trypanosomes is dependent on the receptor-mediated uptake of host macromolecules such as transferrin and low-density lipoprotein (LDL). This takes place only in a specialized surface structure known as the flagellar pocket. The trypanosome transferrin receptor (Tf-R) is attached to the membrane by a glycosyl phosphatidylinositol (GPI) carboxy-terminal tail and is expressed exclusively in the membrane and lumen of the flagellar pocket. I propose to investigate the molecular mechanism involved in the polarized surface expression of trypanosome Tf-R. First, I plan to identify the domain of trypanosome Tf-R which is necessary for pocket retention. The strategy includes the generation of chimeric Tf-R, containing domains of the variable surface glycoprotein (VSG), a GPI-anchored protein expressed on the entire surface of trypanosomes. In addition, I will investigate whether the domain mediating pocket retention is involved in internalization and of trypanosome Tf-R after binding host transferrin. The second part of the project would then be the isolation of molecules that recognize these domain and thereby interact with Tf-R in BF trypanosomes. Training content (objective, benefit and expected impact) I will be trained in the molecular biology of protozoan parasites and to cultivate trypanosomes in vitro and in animals. Furthermore, I will learn to perfom gene targeting experiments in T. brucei which are routinely done in the host lab. I will learn methods for isolating proteins that interact with a given target protein. In the future I want to use the experimental system to investigate the molecular mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Screening Centre; Unique Library for Attractive Biology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

By bridging an important gap between basic research and drug development, ESCulab will facilitate the translation of fundamental scientific insights into innovative drug starting points. New biological ideas will be collected by crowdsourcing, novel targets, phenotypes and pathways translated and de-risked by delivering high-quality chemical starting points for drug development. Innovators from EU academics and SMEs are offered access to state-of-the-art industry-grade facilities, drug discovery expertise, and a top-quality, curated library with over 550,000 unique compounds suitable for screening potential drug targets. The ESCulab drug discovery data generated will allow the innovators to build a proposition that is likely to attract investors and/or drug developers and stimulate them to further exploit these findings. Ultimately, this will result in novel medicines – based on basic scientific findings – that will help patients (sooner).ESCulab will achieve this by starting off the shoulders of the European Lead Factory (ELF), where this principle has been successfully implemented. 15 out of the 18 ESCulab consortium members were involved in ELF, thus ensuring maximum benefit from the ELF legacy. ESCulab will expand and enhance ELF by supporting 185 new screens. Important additions include the application of a much larger compound collection for screening, the ability to accommodate the more complex phenotypic screening assays, and the building of a sustainable business model to ensure access to Collaborative Drug Discovery activities beyond the funding period. The delivery of qualified hit lists (QHLs) is the end point for this project, but during the funding period, ESCulab will attract additonal funding for externally paid screens and hit-to-lead projects for organ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Networking of national / regional funding and innovation organisations for the involvement of SMEs in technology-based innovation clusters in Europe' (INNET) under Sixth Framework.

assistant: **Objectives**

The global objective of the INNET project is to strengthen interactions and cooperation between national, regional and European innovation funding schemes in order to develop SME-targeted activities within European Technology Clusters. This will be done by investigating the mechanisms to promote technology transfer and take up activities (acquisition) by SMEs in the European Member States related to these clusters by launching common Calls for proposals. The INNET project will after one year be able to launch a common Pilot call for proposals and a subsequent call before project end.INNET has 4 specific objectives related to the identification of common issues:- To produce a State-of-the-art of regional and national innovation schemes and technology cluster policies and programmes in the 9 participating countries- To identify and analyze common strategic issues in the area of regional and national innovation schemes and technology cluster policies and programmes.- To design a Pilot call for a cross-border innovation / technology transfer scheme in favour of SMEs- To implement the Pilot call. From the analysis of the call results, design, prepare and implement a second call (or calls) for proposals INNET has 3 objectives related to the embedding of the project in its wider context- To establish and implement efficient internal and external communication systems for the project- To ensure the relevance and sustainability of the project by associating, throughout the project's life-time, a High Level Expert Group- To identify new partners and prepare the follow-up of the project The consortium consists of 19 partners, of which 8 national and 11 regional organizations, from 9 European countries, amongst which 2 organizations from a new Member State.They total an approximate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Leverage synergy by cyber-physical systems for the convergence of the eco systems mobility, infrastructure and energy in the circular economy for the Society 5.0' to be submitted under Horizon Europe.

assistant: **Abstract**

Cynergy4MIE is a visionary project poised to revolutionize Europe's industrial landscape by bridging the gap between foundational technology layers, cross-sectional technologies, and key application areas. The project addresses the pressing need for efficient resource utilization and synergy creation across ecosystems. By actively managing requirements from various key application areas, Cynergy4MIE aims to steer developments in foundational technology layers and cross-sectional technologies, enabling unparalleled collaboration and resource optimization. This approach promises faster time-to-market, efficient resource utilization, and enhanced technological exchange between key application areas. Cynergy4MIE's strategy aligns with the EU's agenda and emphasizes urgency, resilience, technological partnerships, and cross-domain integration to champion European competitiveness. The project's long-term impact rests on embracing urgency, fostering competitive resilience, strengthening technological partnerships, harnessing ecosystem synergies, promoting cross-domain integration, advancing AI competence, prioritizing sustainability, enhancing productivity, and ensuring user-centric digitalization while forming strategic alliances. Cynergy4MIE envisions a future where emergent cyber-physical systems serve human-centric needs, drive domain convergence, and secure Europe's position as a global technology leader.


**Keywords:** Ecosystem Synergies, Key Application Areas, Digital ECS, Synergetic AI, Synergetic CPS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Theory of particle collider processes at ultimate precision', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Large Hadron Collider (LHC) at CERN probes the interaction of elementary particles at unprecedented energy and to very high precision. The full exploitation of the upcoming data from the LHC relies on a close interplay between theory and experiment, which calls in particular for highly accurate theoretical predictions. This theoretical accuracy can be achieved only though the expansion of the fundamental scattering amplitudes to sufficiently high order in perturbation theory.This project aims to meet this challenge for modern collider physics by providing the conceptual and technical foundations for theory predictions at ultimate precision. TOPUP will develop and establish a new standard of theoretical precision in the description of physical observables at the LHC based on perturbation theory expanded to the third non-trivial order (N3LO). We will achieve this ambitious goal by targeting the main obstacles in present-day methods, and by developing novel ways for the computation of multi-loop scattering amplitudes and in the understanding and handling of unresolved multi-particle emission.The concrete goal of the project is to enable theoretical predictions at ultimate precision for multiple processes in high-energy particle collisions with full final state kinematical information. This will lead to a more precise extraction of fundamental physics parameters, such as couplings and particle masses. The newly developed methods will be applied to the derivation of the process-independent four-loop corrections to the Altarelli-Parisi splitting functions, the three-loop matrix elements for a number of fundamental scattering processes and fully differential N3LO predictions for several process-specific key observables. These calculations will shape and challenge the newly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Environmental agent susceptibility assessment utilising existing and novel biomarkers as rapid non-invasive testing methods'.

assistant: **Innovation**

ASYRING will improve information regarding the environmental levels of pollutants, their biological effects as measured with innovative tools to aquatic species and for mammalian risk assessment. It aims to develop and validate novel non-invasive methods for the detection of known and new biomarkers of endocrine disrupters. (Ends) directly in the mucus of aquatic species. Short/long term and low dose exposures to endocrine disrupting chemicals will be investigated both in aquatic species and mammals. In parallel, integrated testing in vitro protocols will permit a wider understanding and evaluation of effects and new instrumental analytical techniques will be developed and validated for easier and more complete detection of chemicals in water and biota. Quantitative structure-activity relationships (Tsars) for the prediction of chemicals able to elicit endocrine disruption and quantitative activity-activity relationships (Quarts) to extrapolate the response of different experimental models will be compared with test data developed in this project. The final aim will be to extend mathematical models to human toxicity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Prevention of hepatitis C virus (HCV) and HIV-1 co-infections through induction of potent T cell responses using prime-boost viral vector vaccine regimens' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of the PEACHI project is to develop simple, affordable and effective vaccine strategies that can be given alone or in combination to prevent hepatitis C virus (HCV), human immunodeficiency virus type 1 (HIV-1) and co-infection. The vaccines are based on novel and powerful viral vectors for in vivo delivery of antigens.The PEACHI Consortium members have employed replication-defective simian adenovirus (ChAd) and modified vaccinia virus Ankara (MVA) vector technology to develop the most immunogenic HCV and HIV-1 vaccines to date. We will assess the safety and immunogenicity of ChAd prime / MVA boost HCV vaccines in a key target group - HIV-positive individuals receiving antiretroviral therapy. These data are essential to support future efficacy studies aiming to assess protection of HIV-infected people from HCV infection. In addition, we will conduct the first phase I clinical studies using two distinct ChAd vectors simultaneously, one hosting an HCV immunogen spanning the entire NS region of HCV and the other, highly conserved HIV-1 sequences. This strategy aims to prime responses against both HCV and HIV-1 antigenic targets concurrently. Similarly, responses will be boosted simultaneously, using MVA vectors that host the respective HIV-1 and HCV immunogens. Finally, recent work by Consortium members has shown that the immunogenicity of ChAd and MVA vectors is markedly improved when the encoded HCV immunogen is fused to mouse or human MHC class II invariant chain. This may be critical to the effectiveness of HCV vaccines in HIV-infected people and will be applicable to vaccine development for other major infectious diseases. Therefore, a large component of this project will be the first assessment of this novel technology in humans. Clinical studies will be comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deep subsurface Archaea: carbon cycle, life strategies, and role in sedimentary ecosystems' (DARCLIFE), addressing dissemination and exploitation.

assistant: **Impact**

Archaea are increasingly recognized as globally abundant organisms that mediate important processes controlling greenhouse gases and nutrients. Our latest work, published in PNAS and Nature, suggests that Archaea dominate the biomass in the subseafloor. Their unique ability to cope with extreme energy starvation appears to be a selecting factor. Marine sediments are of crucial importance to the redox balance and climate of our planet but the regulating role of the deep biosphere remains one of the great puzzles in biogeochemistry. The unique and diverse sedimentary Archaea with no cultured representatives, so-called benthic archaea, are key to understanding this system. Their presumed ability to degrade complex recalcitrant organic residues highlights their relevance for the carbon cycle and as potential targets for biotechnology. I propose to study the role of benthic archaea in the carbon cycle and in the deep biosphere and to explore their life strategies. This task requires an interdisciplinary frontier research approach at the scale of an ERC grant, involving biogeochemistry, earth sciences, and microbiology. Central to my research strategy is the information contained in structural and isotopic properties of membrane lipids from benthic archaea, an area of research spearheaded by my lab. In-depth geochemical examination of their habitat will elucidate processes they mediate. Metagenomic analysis will provide a phylogenetic framework and further insights on metabolism. At the Archaeenzentrum in Regensburg, we will grow model Archaea under a set of environmental conditions and examine the impact on cellular lipid distributions in order to develop the full potential of lipids as proxies for studying nearly inaccessible microbial life. Attempts to enrich benthic archa