RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Water quality monitoring by luminescent cyanobacterial biosensors: a novel early warming system against algal blooms'.

assistant: **Objectives**

The improvement of the quality of water in general, and drinking water in particular, is one of the top priorities in Europe. The understanding of the factors regulating cyanobacterial and algal blooms are needed to prevent degradation of water quality. To reach this goal, we propose a completely novel approach for the monitoring of aquatic environments and also to give warning of impending algal and cyanobacterial blooms. We will construct a set of cyanobacterial biosensors, that produce a real-time signal dependent on the bioavailability of specific nutrients. It is believed that these new tools, once developed, will be accurate, sensitive and cheap. The strategy suggested for achieving this aim is to fuse two genetic elements: (a) promoter regions of selected cyanobacterial genes regulated by either N, P or Fe availability, that will serve as the sensing element of the final construct; (b)bacterial (lux) bioluminescence genes, to serve as the reporting/signaling element. Plasmids containing these fusions will be used to transform unicellular cyanobacterial strains; successful transformants will emit light in response to N, P or Fe availability. In parallel, we will monitor the responses of these recombinant strains to nutrient limitation or availability in synthetic media, and later in water samples collected in different water bodies in order to correlate the observed responses with actual environmental conditions. To increase the practicality of the concept, the luminescent sensor strains will be immobilised and packaged" into an easy-to-use biosensor format that can partially replace the expensive and lengthy chemical determinations, currently in use. These genetically engineered tools will serve a double purpose: (1) they will function as an early warning system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'InteGrated Laboratories to investigate the mechanics of ASeismic vs. Seismic faulting' to be submitted under Seventh Framework.

assistant: **Abstract**

Earthquakes are potentially catastrophic phenomena that have a huge impact on the environment and society. Understanding the physical processes responsible for earthquakes and faulting requires high quality data and direct observations of the underlying phenomena. However, no direct measurements can be made at depth where earthquakes initiate and propagate. Our knowledge of the mechanical properties of fault zones relies on Earth surface observations and experiments conducted in rock deformation laboratories. Despite recent progress, we have much to learn about the mechanics of earthquakes and the complex and inherently scale-dependent processes that govern earthquake faulting.Central Italy is a unique test site that can serve as a natural laboratory for the integration of high resolution data gathered from different disciplines. I propose to develop my innovative and multidisciplinary research to unravel the physico-chemico processes responsible for faulting phenomena ranging from aseismic creep to seismic slip. GLASS will aim to:(i) locate and analyze different types of transient seismic signals from the actively deforming crust, such as fast/slow and high/low frequency earthquakes and non volcanic tremors;(ii) study deformation processes in outcrops of ancient faults that represent exhumed analogues of the active structures today;(iii) characterize the fluid flow and frictional properties of faults in rock deformation experiments;(iv) investigate earthquake nucleation and recurrence by developing numerical models that will be constrained by field and experimental data and calibrated by seismological records.The proposed research will allow to create unprecedented insight into the mechanics of earthquakes and to investigate deformation processes from the crustal to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Study of the role of kainate preferring receptors in the hippocampus'.

assistant: **Innovation**

L-Glutamate (Glu), the major excitatory neurotransmitter of the central nervous system, mediates its effects by activating two types of receptors: receptor-channels (or ionotropic) and receptors linked to a cellular metabolism (or metabotropic, mGluRs). MGluRs are classified into three groups (I,II and III) according to their associated metabolism and agonist sensitivity. Our studies have been focused on presynaptic mGluRs involved in the control of the glutamatergic transrnission in the CA1 area of the hippocampus. We have shown that both group II and group III presynaptic mGluRs could be involved in the control of the synaptic transmission. We have now examined the action of kainate (KA) group of ionotropic Glu receptors in this regulation. We found that KA induces a synaptic depression, likely via a presvnaptic mechanism, and an inward current in the postsynaptic neurone. The aim of the project is to study the physiological role of the KA receptors that we have detected. This study will be carried out by using patch clamp technique in combination with confocal microscopy to investigate the intracellular Ca2+ concentration ([Ca2+]i) changes activated by these receptors. Firstly, we will characterize both the pre- and postsynaptic mechanisms associated to the activation of KA receptors. Using confocal microscopy we will study the regulation of [Ca2+]i by KA in the presynaptic terminals, since a depression of the synaptic current is often associated with the closure of a Ca2+ channel. We will also characterize in detail the postsynaptic current by studying in detail which ion is involved in its generation. Secondly, we will characterize pharmacologically the KA receptors involved since molecular cloning studies have shown the existence of 5 distinct KA receptors subtype
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of load-bearing fibre reinforced composite based non-metallic biomimetic bone implant' (NEWBONE) under Sixth Framework.

assistant: **Objectives**

The aim of NEWBONE is to develop fibre reinforced composite (FRC) material load-bearing implant: to produce at prototype level two resorbable fixation devices in knee/shoulder ligament repair and two non-resorbable bone fixation devices for reconstruction of large bone defects and study the use of developed technologies in complete implants (hip stem, knee) and spine applications.The proposal is high tech SME driven: they represent all the different competence areas needed to develop FRC bone implant. Research institution partners are adding to the competence portfolio and the latest knowledge developed by them is transferred to the use of SMEs.Three major breakthrough innovations are present in the proposal: FRC material is used for load bearing bon e implants; bioactive glass and hydroxyl-apatite is used on the implant-bone interface; a new processing method is applied to allow in-situ modifications of the implant during surgery.The results will cover the gaps that exist in Europe in terms of increased healthcare costs and decreased quality of life of patients as well as of Europe dragging behind US in commercialisation of biomaterials and implant technologies. FRC material will reduce problems caused by stress-shielding of currently used metal implants.Partners include Swiss SME Medacta International SA, producer of hip and knee prosthesis and Finnish company ConMed Linvatec Biomaterials Ltd, producer of sports injury repair systems, both committed to the development of FRC implants to be included to their future product portfolios.Together with all industrial partners involved, the consortium will have the abilities to increase the turnover of European implant industry and take the role of a global leader in the niche sector of FRC load-bearing bone implants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Internal Cooling of Turbine Blades' under Fourth Framework.

assistant: **Concept**

Objectives and content This proposal is aimed at the 3A.3. 'Technologies for Improved Aircraft Efficiency' section of the IMT work program. The use of state-of-the art technology for aircraft design is paramount to keep European manufacturers competitive in world markets and benefits not only the aircraft manufacturer but also the European Community. The overall financial impact of this proposal for the partners is estimated at 25 BECU over the next five years, which could be lost, if the European suppliers lose competitiveness. More specifically, this proposal is directed at the propulsion technologies 3A.3.9. Task to develop and validate numerical methods for design and off-design analysis of turbomachinery components and in particular the internal cooling of turbine blades. The estimated economic impact from this project alone is some 200 MECU over the next five years for the industrial partners. Internal cooling of modern turbine blades is essential for efficient engine performance and predictable blade lives. Blade cooling benefits specific thrust and efficiency by allowing higher cycle temperatures to be employed, however, bleed air used for cooling, imposes cycle penalties and reduces aerodynamic efficiencies. Cooling research aims to develop and validate improved design methodologies that give maximum cooling effectiveness for minimum cooling flow. The design methods need to be reliable reducing risk in future projects helping to avoid in-service short falls and high maintenance costs. Design methods have been almost exclusively derived from experiments performed using simplified cooling geometries and without the influence of rotation, which is perfectly feasible for nozzle guide vane designs but sadly lacking for rotor designs. However, it is important to purs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Smart communicating applications using radio frequency' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

A highly-integrated, low-cost bidirectional RF transceiver developed using an advanced BiCMOS4 technology, ensuring low power consumption and operation at high frequency.Tools for RF hardware and application design in the form of development kits and software libraries for a range of microcontrollers.Equipment and methods for conformance testing in accordance with established standards, to ensure that the RF medium and resulting applications developed on the basis of the RFIC conform with established norms.A commercial application utilising the new RFIC as its hardware base and providing a means to automate meter reading in the utility industries (electricity, gas, water and heat) and entry into the Home Automation (HA) segments in Europe.A low-cost, single-chip RF IC transceiver suitable for consumer as well as industrial and commercial applications is to be developed. This component will be accompanied by development tools (in the form of ready-to-use demonstration circuits and software libraries for standard microcontrollers) enabling the development, testing and validation of low power RF applications. The component will be integrated and validated in a commercial application, Automatic Meter Reading, and will demonstrate its viability in the domain of Home Systems in the process. The goal is to reduce the cost and performance barriers to the mass scale implementation of low-power RF applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Toward a better understanding of planet MErcury's Redox conditions: implications for its bulk Composition and Internal structure' (MERCI) targeting Horizon Europe.

assistant: **Abstract**

Mercury is the innermost and smallest planet in our Solar System, having unique chemical and structural characteristics. Past NASA space missions have revealed Mercury’s exceptionally high density and surface lavas with high S and low, but measurable, Fe content. These observations point to two key features: i) an extremely reduced interior (very low oxygen fugacity) and ii) a large metallic core, where most of the Fe is hosted. Over the past decade, the integration of geophysical data and modelling with high-pressure and -temperature experiments has helped to develop a picture of Mercury’s interior, although very large uncertainties remain. BepiColombo, a new space mission led by ESA and JAXA, will begin orbiting Mercury in November 2026 and is expected to deliver new high spatiotemporal-resolution data (2027-2028). However, to fully interpret them, new experiments simulating Mercury’s interior conditions are necessary. In this context, the MERCI project aims to provide more accurate experimental and thermodynamic constraints on the redox conditions of Mercury’s interior, with implications for its bulk composition and internal structure. The main objectives are i) understanding Fe distribution from the mantle to the surface lavas and ii) to constrain Si partitioning behaviour under reducing conditions and, thus, determine mantle and core bulk compositions. MERCI will provide a fundamental reference dataset that I will use for the analysis and interpretation of the mission spectroscopic and geophysical observations. This will help to maximize BepiColombo scientific impact and return, since it was largely financed by the European Union. The MERCI timeline and multidisciplinary approach, along with the supervisor’s key scientific role in the mission and significant contri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimizing music-based rehabilitation for post-stroke aphasia' (OPTIMUS) under Horizon Europe.

assistant: **Objectives**

Aphasia causes severe impairments in verbal communication, coupled with cognitive and motor deficits and depression, making it the most debilitating and socioeconomically burdening consequence of stroke. As our population ages and prevalence of stroke and associated care costs increase, persons with aphasia (PWA) often do not receive sufficient rehabilitation in public health care. Effective remote rehabilitation applications are urgently needed to ensure comprehensive and cost-effective aphasia care. PWA often retain the ability to produce words through singing, and rehabilitation methods using music and singing are promising tools for enhancing communication and psychosocial wellbeing in aphasia. However, there are currently no music-based remote rehabilitation applications available for PWA, which greatly limits the inclusion of music in aphasia care.In OPTIMUS, I will lead the development of a novel and innovative multicomponent music-based remote rehabilitation (MMRR) programme for aphasia and determine its usability, applicability, and effects, first through pilot experiments and engagement with stakeholders (PWA, patient associations, rehabilitation staff) and then in a 3-month feasibility randomized controlled trial in 30 PWA. Compared to existing aphasia rehabilitation methods, MMRR has the added value of being more (i) versatile, targeting verbal, cognitive, motor, and emotional functions through multiple musical training modules (singing, rhythm & movement, music listening); (ii) enjoyable and motivating, enabling better adherence to treatment protocol and larger training volumes; and (iii) widely scalable and easy to implement in stroke rehabilitation.OPTIMUS will have major scientific, clinical, and societal value and can lead to a breakthrough social innov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploring the cellular heterogeneity underlying 'tumor-educated' platelets' (PlateletLiquidBiopsy) under Horizon 2020.

assistant: **Objectives**

Cancer is one of the major causes of death worldwide. Early detection leads to treatment initiation in earlier cancer stages and therefore increases the chance of survival. However, appropriate diagnosis can be challenging because tissue acquisition of tumor samples for molecular testing often requires invasive procedure. To overcome these challenges researchers have focused on the real-time monitoring of molecules and cells in easily obtainable peripheral blood to gain diagnostic information, termed 'liquid biopsies'. A recent study by Best et al profiled purified platelet gene expression from cancer patients and healthy controls and was able to predict disease status and location of the primary tumor with 96% and 71% accuracy, respectively using a machine learning based algorithm. The pan-cancer nature of their finding is a major advancement compared to other liquid biopsy approaches and highlights the utility of platelets as an all-in-one platform for blood-based cancer diagnostics. We plan to advance the idea of platelet liquid biopsies by studying platelet single-cell RNA sequencing data from cancer patients and healthy controls. The overall goal of the proposed project is to investigate single platelet gene expression to gain insight into the molecular mechanisms underlying tumor driven changes in the platelet RNA profile.


**Keywords:** Single-cell, RNA-sequencing, platelet, liquid biopsy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biological neural networks: from structure to function' to be submitted under Horizon 2020.

assistant: **Abstract**

The present project lies at the connection between theoretical and experimental neuroscience. It investigates how information is processed in neural networks with feedback, via the firing activity. On the one hand, the past decades have seen a growing interest for the analysis of the functional connectivity, namely how the spiking activity of neural populations is organized spatially and temporally. These activity patterns are hypothesized to form the basis of neural information, i.e., how neurons collectively encode information. On the other hand, experiments have revealed the complex design of the neural circuitry with many levels of organization, from the local connectivity of neurons to broad-scale pathways between cortical areas. NeuArc2Fun aims to develop a recurrent neural network model that bridges these structural and functional levels. The advantage of this model-based approach is the ability to make predictions about the role of each component of the model - in particular, its connectivity - in shaping neural activity. A key issue is to keep a balance between the mathematical tractability and biological realism in the model. To address this trade-off problem, NeuArc2Fun focuses on the mesoscopic level, namely scales at which many interacting neural populations can be simultaneously recorded by current state-of-the-art experimental techniques, such as electrode arrays. In practice, experimental data from the visual cortex will be used to tune and test the network models. In turn, gaining precise knowledge about neural cognitive processing will be applied to design experiments and test new ideas for information coding in networks. To a broader extent, this project will also benefit to applications that involve information decoding and interaction with the brain