RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Participatory science toolkit against pollution'.

assistant: **Innovation**

ACTION will transform the way we do citizen science (CS) today: from a mostly scientist-led process to a more participatory, inclusive, citizen-led one, which acknowledges the diversity of the CS landscape and of the challenges CS teams have to meet as their project evolves. We have partnered with 5 European CS initiatives tackling major forms of pollution, which pose substantial threats to human health and to the environment, and contributing to Sustainable Development Goals. These pilots will be the starting point for a ‘citizen science accelerator’, which will be expanded through an open call. By considering the needs of multiple stakeholders throughout the lifecycle of CS, we will create methodologies, tools and guidelines to truly democratise the scientific process , allowing anyone to design and realise a CS project from the early stages of ideation to validating and publishing the results. Our research will account for the multitude of manifestations of CS, addressing everything from from small-scale, localised social issues to international research agendas. All ACTION’s outputs - infrastructure, the citizen science platform and toolkit - will be made openly available for online and offline use. They will use accessible formats and interfaces, which appeal to audiences with diverse motivations and backgrounds and provide detailed examples, workflows, and advice tailored for a range of activities, going beyond data collection and analysis. Our digital infrastructure will help citizen scientists use existing specialised platforms and publish results according to RRI principles, including open science. Our toolkit will tackle common difficulties around methodological choices, quality, incentives, community building and sustainability. In addition, the 35 pilots hos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cardiac open reading frame edition to study cardiomyopathies in pigs' (Cor-Edit-P).

assistant: **Concept**

Heart failure represents a common cause of death in European societies and is frequently based on dilated cardiomyopathy (DCM) which might be caused by mutations in cardiomyocyte genes. While no specific treatment exists, new therapeutic options are a major unmet clinical need.As attractive novel key approach, Cor-Edit-P will use Crispr-Cas9 based gene editing for distinct gene therapy of genetic cardiomyopathy, using pigs as a unique, clinic-related large animal model system. My lab tailored highly cardiotropic adeno-associated viral (AAV) vectors and their use in pigs in vivo, applying precise, reliable and versatile Cas9 technology. Pioneering this approach, we were able to restore significant dystrophin expression in muscles and hearts of pigs suffering from Duchenne muscle dystrophy.Exploiting unique and cutting-edge technology, Cor-edit-P aims at specifically eliminating the underlying cause of genetic DCM to improve cardiac function, reduce the risk of deadly arrhythmias and increase span and quality of life. Cor-edit-P will-generate currently lacking porcine models of genetic cardiomyopathy, using AAV-Cas9 to induce mutations in sarcomere genes, e.g. titin (TTN) and ß-myosin heavy chain (MYH7);-exercise curative Crispr-Cas9 mediated gene editing of DCM in pigs in vivo, using the PLN-R14del mutation in the phospholamban (PLN) gene as prominent example;-use human patient-derived PLN-R14del ventricular progenitor cells for gene correction ex vivo followed by transplantation of corrected cells into PLN-R14del pigs.Our approach implements a new paradigm for treating genetic cardiomyopathy and develops Crispr-Cas9 based gene therapy in pigs to foster clinical translation. Our work will influence the development of gene therapy by industry and academia and will benefit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mechanotransduction in Cell-to-Cell Communication'.

assistant: **Innovation**

Cell-to-cell communication pathways coordinate cellular functions in multicellular organisms. Cells that are nearest neighbours can communicate through specific interactions between ligand and receptor proteins present in their respective cell membranes. The objective of this research program is to address the hypothesis that the physical context of the ligand/receptor interaction contributes to defining the fundamental mechanisms of action of cell-to-cell communication pathways and their cellular outcomes.The research program relies on the development of tools that provide well-defined physical inputs to cells, not confounded by simultaneous changes in chemical inputs. Therefore, beyond state-of-the-art developments in nanotechnology are here integrated with cell biology. In particular, DNA origami technology is applied to the development of ligand nanoclusters with customized spatial organization and mechanical properties. These ligand nanoclusters are used to probe the roles of physical properties of the ligand presentation on the activation of intracellular signalling pathways.We will focus on the ephrin/Eph cell-to-cell communication pathway, which regulates embryonic development and the homeostasis of adult organs. ephrin/Eph signalling is commonly disrupted in cancer, showing tumour suppressing or tumour promoting character. The mechanisms that generate the diversity of outcomes of the ephrin/Eph pathway are largely unknown. We will use DNA origami/ephrin ligand nanoclusters to investigate whether the spatial organization and mechanical properties of ephrin ligand assemblies impact Eph receptor function and contribute to generating diversity in the pathway. Our novel approach is readily transferrable to the study of other signalling pathways. We aim to generate a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Highly Efficient and Low-impact InnOvative TheRmal stOrage system for enhanced disPatchability in concEntrated solar tower plants'.

assistant: **Concept**

HELIOTROPE is a groundbreaking research and development endeavor dedicated to advancing Concentrated Solar Power (CSP) technology to unprecedented heights. This project focuses on developing state-of-the-art molten salts and materials technologies for thermal energy storage systems, pushing the boundaries of operational temperatures beyond the current industry standard of 600ºC. A holistic approach is at the heart of HELIOTROPE's mission. Sustainable novel molten salts as thermal energy storage mediums and the remarkable ability to withstand absorber surface temperatures of up to 850ºC are introduced, promising to enhance CSP plant efficiency and dispatchability. This technological advancement aims to redefine the capabilities of CSP plants. Furthermore, HELIOTROPE aligns closely with key European energy policies and initiatives, contributing significantly to energy security, reducing reliance on fossil fuels, and lowering greenhouse gas emissions. The project supports the vision outlined in the European Green Deal, Clean Energy for All Europeans, and the Fit for 55 legislations, fostering sustainability and competitiveness in the energy sector. HELIOTROPE aspires to reshape the CSP plant landscape, making them not only more efficient but also inherently environmentally friendly. The project represents a significant stride towards a sustainable energy future, where CSP technology leads the way in innovation and progress, redefining the boundaries of what is possible in the pursuit of a cleaner, more sustainable energy world.


**Keywords:** CSP thermal energy storage, Sustainable molten salts, Energy efficiency improvement, Cost-effective and reliable solutions, circularity by design, Environmental sustainability, Socio-economic impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pioneering Ultra-Low Power Computing: A Disruptive Integrated Mechanics Paradigm' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nanoelectromechanical (NEMS) switches offer 10 to 100 times less power consumption than conventional transistors, but their widespread adoption is hindered by challenges related to adhesion, electrical contact resistance (ECR), and in-operando property evolution. This project aims to address these issues by developing reliable interface coatings capable of withstanding the harsh conditions of NEMS interface, such as high stresses, repetitive cycling, and Joule heating. Oxide formation on metal contacts is unavoidable, unlike tribopolymers. Though they are typically insulators, but can conduct electricity via electron dispersion and are proven effective in harsh environments. Oxides also offer advantages over metals, including high strength, low adhesion, and resistance to creep and fatigue, and can replace metal contacts completely. The proposal turns the liability into an advantage by considering oxides as a potential solution for NEMS switch interface. The project will use a materials genome search to select hard oxides with distinct conduction mechanisms—semimetals (RhO2, RuO2, TiOx), semiconductors (TiO2), and oxides with oxygen vacancies (Ta2Ox). Advanced characterization techniques such as TEM, XRD, and XPS will assess coating quality. To streamline the complex fabrication and testing process, an innovative in-situ AFM method with integrated plasma cleaning (to ensure clean environment), and controlled environment will be developed, enabling real-time monitoring of asperity interactions. This approach will directly link nano-asperity responses to actual NEMS interfaces. MD simulations will guide experiments, provide atomic-level insights, and develop semi-empirical prediction models for further development of NEMS switch architecture. This project aims to revoluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Driving asymmetric photoreactions by merging organo- and gold-catalysis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection comprising optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. Also, the chemistry community has recently recognized how visible light-mediated photoreactions can open new avenues in modern organic synthesis and the past seven years have witnessed its remarkable prosperity. Therefore, developing photo-facilitated asymmetric reactions focusing on rapidly generating privileged chiral natural-like compounds for drug discovery are highly desirable.  The proposed research aims to combine the fellow’s experience in gold catalysis and the host’s experience in photo-triggered organocatalysis (two powerful fields of molecule activation, which have to date remained unrelated) to develop otherwise unachievable catalytic asymmetric photoreactions. Specifically, we will focus on using readily available, unactivated aryl/alkyl chloride or bromide, which cannot be easily activated by the commonly used Rh- or Ir-based photoredox catalysts. The resulting strategies will be used as an ideal platform for assembling libraries comprising enantiopure chiral small molecules bearing α,α-disubstituted α-amino acid & 3,3-disubstituted oxindole frameworks, which, along with biological screening carried out in collaboration with a world-wide recognized pharma-company (Lundbeck A/S, Copenhagen, DK), will increase the probability of success in identifying drug-candidate structures. The multi-cultural nature of this project will greatly contribute to broaden the fellow competencies and will place hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Growing Up in Digital Europe Preparation Phase (GUIDEPREP)' in the context of a Horizon Europe call.

assistant: **Objectives**

The Growing Up in Digital Europe Preparatory Phase (GUIDEPREP) project further develops the research infrastructure (RI) necessary to implement the GUIDE birth cohort study. This preparatory work will take place across 2022 to 2025 to ready the RI for the full-scale piloting of the GUIDE in 2026 and the first full wave of data collection in 2027. Once operational, GUIDE will collect data about individual children growing up in Europe until those children are aged 24-years in approximately 2053.GUIDE will be Europe’s first comparative birth cohort study of children’s and young people’s wellbeing. The aim of the GUIDE study is to track children’s personal wellbeing and development, in combination with key indicators of children’s homes, neighbourhoods, and schools, across Europe. GUIDE will be an accelerated cohort survey including a sample of infants as well as a sample of school age children. Each Member State and Associated Country will provide nationally representative samples that are designed to retain statistical power throughout the lifetime of the study. The harmonized design will create the first internationally comparable, nationally representative, longitudinal study of children and young people in Europe. Currently the GUIDE RI is in its preparatory phase, which involves the establishment of necessary operational procedures and further crystallisation of the study concept and design. To realise the GUIDE full-scale pilot in 2026 and first wave of fieldwork in 2027, the RI needs to develop administratively, technologically, financially, scientifically, and legally. This GUIDEPREP proposal lays out clear aims for these developments in an interlocking system of activities that are shared across consortium partners and managed by the GUIDE leadership team.


**Ke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Support for the Intergovernmental panel on Climate Change (IPCC) to facilitate the preparation of its Sixth Assessment Report (AR6)'.

assistant: **Objectives**

The Intergovernmental Panel on Climate Change (IPCC) is the key global climate science-policy interface, underpinning international climate change policy-making and is the leading global body responsible for the scientific assessment of climate change.  In preparation of the IPCC Sixth Assessment Report (AR6), support will be provided to increase the participation of experts from developing countries and economies in transition, should their governments not be in a position to provide appropriate funding, to the IPCC process. Support will also be provided to enhance the visibility of the IPCC products globally.


**Keywords:** climate change, adaptation, mitigation, impacts, vulnerability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring Morphospaces in Adaptive Radiations to unravel Ecological Speciation' under Seventh Framework.

assistant: **Concept**

150 years from the Origin and we have yet to unravel how ecological speciation works, and how it leads to spectacular adaptive radiations. The process has two components: adaptation to ecological niches and production of new species. My aim is to make breakthroughs in understanding ecological speciation by the study of geographically parallel adaptive radiations in mycalesine butterflies that have yielded some 250 extant species in the Old World tropics. More empirical studies are needed because few radiations have been examined from many different perspectives (including in insects). It is not fully understood either how exactly radiation occurs or how exactly selection leads to speciation. This proposal provides a unique opportunity, outside a few vertebrate clades, to resolve this by fully integrating several lines of evidence and methodologies. My approach will be to study patterns of diversity and disparity in morphospace for several sets of key traits: 1) wing patterns, 2) larval host plant choice especially with respect to C3 and C4 photosynthesis, and 3) male secondary sexual traits and sex pheromones. We will collect phenotypic, genetic, developmental, and ecological data. Application of phylogenetic comparative methods to the relationships of all traits among all species will make inferences about the biological mechanisms that have driven diversification and speciation. The combination of surveys of morphospace, the use of comparative methods, and microevolutionary studies using laboratory models will provide a unique comprehensive view. Our analyses will distinguish among alternative patterns of adaptive radiations, test predictions from models, and move us forward in identifying the drivers of observed patterns.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Horizons in Glass Structure Prediction and Mechanics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Oxide glasses are one of the most important material families owing to their unique features, such as transparency, tunable properties, and formability. Emerging solutions to major global challenges related to energy, health, and electronics require new scientific breakthroughs in glass chemistry, mechanics, and processing. The realization of these goals is severely restricted by the main drawback of glass, namely high brittleness. Furthermore, new glass compositions are today developed through time-consuming trial-and-error experimentation due to their inherent non-equilibrium nature and disordered structure.A major task is therefore to initiate a paradigm shift within the field of glass science and technology, going from empirical to model-based approaches for the design of new glass compositions and microstructures with improved fracture resistance. This requires the development of computational approaches, from ab initio calculations to artificial intelligence, to integrate structural descriptors and glass chemistry with advanced processing and mechanical properties into holistic tools.NewGLASS challenges the current glass design strategies in order to create such tools. For this purpose, an interdisciplinary approach is proposed, in which structural descriptors at the short- and medium-range length scales are first identified and quantified based on emergent statistical mechanics and persistent homology techniques. Guided by these results, high-throughput simulations at various length scales are combined with machine learning algorithms to design novel glass compositions, tailored deformation mechanisms, and 3D-printed microstructures to achieve superior fracture resistance. By having experiments and modelling complement and advance each other reciprocally, NewGLAS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Efficiency improvement of cut-to-length lines by developing a new generation of stracker, uncoilers and control and operation systems for stockholders' under Fourth Framework.

assistant: **Concept**

Stockholders are companies which produce steel, aluminium, stainless steel blanks or blanks made of other material in required number and dimensions for their customers. These blanks are produced by a cut to length line. The industrial problem is the poor overall production efficiency for cut to length lines of about 25 % . The objective of the project is to develop prototypes of a new generation of stackers, uncovers and control and operation systems to increase the efficiency of a cut to length to 50 %. Brit/Euram Areas covered by the proposal are area 1.1, 1.4 and 1.5