RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Joint programming actions to foster innovative CSP solutions'.

assistant: **Concept**

CSP ERANET is the result of a joint EU will for bridging the gap between research and commercial deployment in the Concentrated Solar Power (CSP) technology, so this technology can play a main role in the European renewable electricity generation in a medium term.For this purpose, the main European countries and regions, with roles to play in the future CSP deployment (industrial or academic stakeholders), have committed their economic resources to create big-scale funding synergies able to finance strategic CSP research.CSP ERANET aims to coordinate the efforts of Member States, Associated Countries and Regions towards achieving CSP SET Plan objectives, by pooling their financial resources to implement joint calls for R&I proposals, resulting on strategic projects with substantial volumes of investment, which cannot be allocated by individual countries or by the European Commission on their own.By pooling funds, CSP ERANET will achieve to finance large-scale projects implementing medium/high TRL research, which will accelerate the time to commercial deployment of affordable, cost-effective and resource-efficient CSP technology solutions.CSP ERANET constitutes a public-public partnership gathering 11 representatives from Member States, Associated Countries and Regions which have committed more than 9 million EUR public fund for launching the Cofund joint calls for proposals and more than 6 million EUR for the additional call to finance transnational research actions.During the 5 years of CSP ERANET the consortium intends to pool together financial resources from multiple countries, the Commission and the private sector, in order to invest more than 36 million euros (Cofund + Additional Call) in researching for innovative CSP solutions.This investment will finance 8 topi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of signalling Pathways controlling adult neural stem cell maintenance', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The adult hippocampus plays a central role in learning and memory. Hippocampal dysfunction is a main cause of cognitive impairment during aging and in Alzheimer's disease. There is increasing evidence that the generation of new neurons (neurogenesis) from neural stem cells (NSCs) in the adult hippocampus significantly contributes to hippocampal function. Indeed, progressive loss of NSCs in the aging hippocampus due to incomplete maintenance of the NSC population and the resulting decrease in neurogenesis are associated with a decline in cognitive function.The aim of this project is to identify the extrinsic signals that control the maintenance and self-renewal of NSCs through the regulation of the transcription factor Sox2. The rationale for this approach is the fact that Sox2 expression is essential for maintenance and self-renewal of adult hippocampal NSCs. Experimentally candidate signals will be identified by a combination of in silico, in vitro, and in vivo experiments. Functional studies in vitro and in vivo will test the involvement of the candidates in the control of Sox2 expression. These studies will not only promote our basic understanding of the signalling networks underlying NSC maintenance in the hippocampus but may also significantly contribute to the design of novel therapies for cognitive impairment and dementia given the link between hippocampal neurogenesis and cognitive function.In this regard, the proposal displays significant overlap with the priority of the FP6 to combat chronic diseases and will substantially strengthen European research activities in this area. The project will also allow the re-integration of the applicant, who has received outstanding postdoctoral training in NSC-biology in a third country (USA), and will enable the transfer o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Restoration of deep-sea habitats to rebuild European Seas'.

assistant: **Concept**

REDRESS aims to provide a key contribution to the EU commitments towards restoring degraded ecosystems, especially in the deep sea. REDRESS will provide solutions to prioritize future restoration actions, extend deep-sea restoration to previously neglected habitat types, and demonstrate the feasibility, potential, and value for success of deep-sea ecosystem restoration. The project will focus on habitats that have great potential to contribute to carbon sequestration and climate mitigation but have been degraded by deep-sea fishing, especially trawling. Specifically, we will study vulnerable marine ecosystems, including sea pens and bamboo corals on soft sediments, coral gardens, cold-water coral reefs, sponge fields, and cold seeps. REDRESS will map degraded deep-sea habitats and identify habitat refugia to prioritize restoration efforts that will adapt to future scenarios of climate change. To adopt and adapt cutting-edge solutions for both restoration interventions and monitoring, REDRESS will make a significant technological investment and will benefit from a relevant ship time by in-kind contribution (136 days). REDRESS will offer nature-based solutions to public authorities and operators to advance ecosystem restoration in the deep sea. Building on the MERCES experience, REDRESS will go beyond the state of art, either developing new methodologies, using sophisticated technologies, defining success indicators, and expanding the target habitats also to cold seeps. The results will enable a significant advancement in the EU's marine restoration strategy. The project will also provide socio-economic data, protocols, and tools to plan, and upscale restoration interventions in deep-sea habitats. REDRESS will provide novel insights into the advantages and limits of activ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FLow Induced Phase Transitions, A new low energy paradigm for polymer processing' under Horizon 2020.

assistant: **Concept**

Currently there is no truly sustainable pathway for the production of plastics, an industry which in the EU employs 1.45M people, has a turnover of €89B but consumes ~778GWh of energy per annum. This is an opportunity for industry with pressure increasing to develop low energy, high-quality, wet-processing techniques for consumer products. Here Nature may provide us with inspiration, as over hundreds of millions of years, it has evolved numerous strategies for efficient processing of its materials. One such solution has been recently hypothesised in natural silk spinning: FLIPT: FLow Induced Phase Transitions, a disruptive process which we believe could hold the key to a new low energy paradigm for polymer processing. Our research is promising, as it has already shown that silk is at least 1000 times more efficient at processing than a standard polymer (HDPE).To address these challenges our consortia will combine the expertise of world-leading groups in natural materials, polymer synthesis and material processing alongside practical input from 2 SME partners and larger European companies. Taking inspiration from the spider and silkworm, novel functionalised polymers (‘aquamelts’) will be created that utilise FLIPT; enabling controlled solidification with minimal energy input. We firmly believe that there is huge potential in uncovering silks hidden functionality and applying it to enhance the processing of a range of polymeric materials. It is our goal to develop a platform technology to generate novel, bespoke, naturally derived, low embodied-energy materials, which would be competitive with current petroleum-based polymers in terms of performance and economics while well exceeding such materials in terms of sustainability.


**Keywords:** Biopolymers, Silk, Cellulose,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Health effects in aircraft cabin environment' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

HEACE aims to achieve a better understanding of the health and comfort impact of the workplace inside aircraft on both crew and passengers. This understanding will be translated into improvements, to be promoted by defining appropriate schemes, measures, guidelines and tools for aircraft design. Physical environmental parameters (noise, vibration, air flow, temperature, lighting etc.) are measured in-flight and in specially prepared mock-ups and correlated with psychological, physiological and sociological and performance data from test subjects. The multidimensional state of comfort perception with respect to health, well-being and consequently performance of cabin crew and flight crew is evaluated and a human response model derived, based on both statistical analysis and artificial neural network structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'On-chip Phase and Polarization Engineering of GaN-based blue/UV VCSELs via Metasurfaces' (MetaVCSEL).

assistant: **Innovation**

Vertical cavity surface-emitting lasers (VCSELs) play a key role in the development of modern optoelectronic technologies, thanks to their unique characteristics such as low power consumption, high modulation speed, and large-scale two-dimensional array capability. To further expand the spectral range of VCSELs from the red/near-infrared region down to the blue/UV region is attracting significant interest. This will lead to versatile applications in for example retinal scanning displays, visible light communications, chemical sensing, and sterilization of viruses and bacteria. However, blue/UV VCSELs are suffering from poor beam quality and unstable polarization property due to the lack of effective beam shaping solutions. The recent advances in two-dimensional metamaterials, also known as metasurfaces, open new perspectives for the manipulation of light properties, including amplitude, phase, and polarization with exceptional subwavelength spatial resolution. In particular, the ultra-thin, flat, and compact characteristics of metasurfaces greatly facilitate their integration with semiconductor laser for the development of a miniaturized laser system with a controllable optical wavefront. Seizing on the timely opportunities provided by the latest metasurface technologies, this project aims to develop the very first solution for on-chip beam-shaping blue/UV VCSELs by exploiting metasurface optoelectronic integration, which will unlock the potential to tailor both the phase and polarization properties of blue/UV lasers at an ultra-compact wafer-level. This will give rise to high beam quality lasers with small divergence angle and vector lasers in the blue/UV regime, paying their way toward real-world applications.


**Keywords:** metasurface, semiconductor lasers, VCSELs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and application of high throughput molecular methods for studying the human gut microbiota in relation to diet and health' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The proposal is aimed at understanding the functional interactions between food, intestinal micro flora and health. Novel methods are to be developed to understand and exploit the nutrition driven impact of the human gut micro flora on health. Since the presently used methods for micro flora analysis are time consuming and tedious, high throughput methods for the automated detection of fluorescentlylabelled cells based on microscopic image analysis, flow cytometry and DNA arrays will be developed. In site detection methods for monitoring bacterial gene expression at the cellular level will be developed to monitor the impact of dietary constituents on the transcription of bacterial genes. Samples from human populations will be analysed with the developed methods to identify key factors of micro flora development, composition and activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Setting the optimal balance between metabolite supplementation and deprivation in cancer therapy' to be submitted under Horizon Europe.

assistant: **Abstract**

The goal of this proposal is to explore combinations of targeted metabolite supplementation and global nutrient restriction as a new strategy to reprogram tumor metabolism, to halt tumor progression and to improve response to treatments. Preclinical and clinical studies published by our group and by others showed that global nutrient restriction, in the form of cyclic fasting or fasting-mimicking diets (FMDs), produces desirable metabolic and immunologic effects that result in reduced tumor progression and in the prolongation of animal/patient survival. Of note, our unpublished results indicate that the supplementation of specific amino acids or fatty acids has in vitro and in vivo antitumor effects, which are strongly enhanced when metabolite supplementation is combined with nutrient starvation. By employing canonical cell biology and biochemical experiments, polysome/ribosome profiling, isotope tracing experiments and integrated omics (transcriptomic, proteomic, metabolomic) analyses in in vitro and in vivo murine and human tumor models, here we propose to:-identify the cell-autonomous and immune-mediated mechanisms at the basis of the antitumor effects of targeted metabolite supplementation in combination with global nutrient restriction;-identify the most effective metabolite supplementation-restriction strategy to be tested in a first-in-human clinical trial in patients with advanced triple-negative breast cancer. While the basic cancer research and medical oncology communities are engaged in a historical scientific and clinical diatribe on the use of nutrient deprivation vs. supplementation approaches to halt tumor progression and to improve patient survival, we will exploit our unprecedented ability to conduct parallel preclinical and clinical experimentation in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'COntinuous VAriable Quantum Information with Atoms and Light'.

assistant: **Concept**

In the recent years, quantum continuous variables (QCV) have emerged as a tool of major importance for developing novel quantum communication and information processing protocols. Encoding quantum continuous information into the quadrature of a quantized light mode or into the collective spin variable of a mesoscopic atomic ensemble has proven to be a very interesting alternative to the standard concept of quantum bit-based processes. Several experimental breakthroughs have been achieved recently demonstrating this concept, namely the quantum teleportation of a coherent state, the generation of entangled light beams with soliton pulses in nonlinear fibers, the preparation of distant entangled atomic ensembles, or the implementation of a quantum key distribution scheme relying on coherent states. In view of these spectacular results, many developments of QCV information systems can be foreseen.The present proposal aims at initiating an exploratory research on new quantum informational concepts involving continuous variables, both on the theoretical and experimental sides. It departs from the traditional" approaches of quantum computing in that we do not address the "scalability" of some potential technology for quantum information processing which is not yet applicable. Instead, we start from a concept that has already been proven very successful in the laboratory. The topics which we plan to cover include improved or novel quantum communication protocols, quantum memories and quantum repeaters based on the light-atoms quantum interface, and the generation of squeezed or entangled solitonic light beams based on various nonlinearities in fibers. The role of non-Gaussian states of light will also be investigated in order to make new QCV informational processes possible. An
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biomimetic nano-coatings for healthcare. Targeting the contact lenses market' (LIPOCOAT), addressing dissemination and exploitation.

assistant: **Impact**

Biofouling, i.e. the formation of deposits of biomolecules or even bacteria in the surface of the medical device, is the main cause of the loss of the devices performance. LipoCoat’s patented nano-coatings make use of lipid bilayers to prevent biofouling of medical devices when placed into contact with bodily fluids in- or outside of the body. Our natural and bio-inspired coating makes use of molecules found in every cell, making it extremely biocompatible. The neutral LipoCoat molecules can efficiently attract water thus preventing any interaction with proteins and cells. Furthermore, LipoCoat can stably apply these layers using our proprietary LipoCoat FAST manufacturing process. Among the wide range of biomedical applications for LipoCoat nano-coatings, we decided to target the contact lenses as it presents a clear business opportunity (a € 11.4 billion global market with a projected CAGR of 7-10% 2014-2019). Demo studies, both in vitro and in vivo, have demonstrated the LipoCoat coating efficiency and its benefits on contact lenses: 95% reduction in bacterial adhesion, improved wetting and lubricity and comfort improvement. In view of these promising results, we were able to establish close ties with leading national and international CLs manufacturers. The next step for LipoCoat’s commercial success on the contact lenses market, which comprises the main objective of this project, is the industrialization of our proprietary manufacturing process to scale-up the production of LipoCoat nano-coatings. We expect a time-to-market of 2 years, launching our product on the CLs market by 2020. Our initial sales forecast estimates a cumulative cash flow of € 32.2 million after the five first years of commercialization. The estimated investment needed, € 2 million, will be rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Rapid and easy- test for Coronavirus infections' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The coronavirus outbreak in 2019 (Cov-19) has challenged the global healthcare system to contain a virus with unprecedented contagious capabilities. A major aspect for controlling the Coronavirus pandemic is the implementation of tools that allow rapid screening of patients at the healthcare centers and not only. Fast and accurate diagnosis of early infections will facilitate the clinical management of the virus, and will improve patients' prognosis. The diagnostic gold standard for Coronavirus is the RNA detection of pharyngeal swab specimen by RT-PCR. However, the limitations of time, need of devices and specialized personnel to perform RT-PCR, combined with the rapid spread and universal susceptibility to the general population, make this diagnostic technique incompatible with the urgent medical needs. Moreover, the number of RT PCR kits available are limited and the production cannot cope with the high demand. The main objective of this study is to develop a rapid, easy and economical screening test for Coronavirus with the capability to achieve results in less than one hour, with high sensitivity and specificity. The test will be used to screen asymptomatic or mildly symptomatic individuals, which can risk community transmission to population categories at a higher risk (elderly with underlying conditions, among others). Corona-Test is a lateral flow strip test similar to the well-known pregnancy test. Herein, we are aiming to validate the diagnostic accuracy and screening efficacy of Corona-Test.  This strategy could provide the means to prevent and control the disease. The objective of this project will be to bring two different applications of the test to market within 20 months.


**Keywords:** Coronavirus