RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cultural Loss Under Emulated Shocks – Demographic Environmental Climatic Empirical Bottlenecks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cultural loss is a common phenomenon throughout human history, often in relation to major external shocks. Yet, there are few studies that analyse which process might govern it. CLUES-DECEB (Cultural Loss Under Emulated Shocks – Demographic Environmental Climatic Empirical Bottlenecks) homes in the resilience of culture under demographic and environmental shocks – prognosed to become more frequent and severe. By modelling and analysing drastic changes in population or in the environmental brought about by epidemics, climate change, mass-migrations, or natural hazards, CLUES pursues two key objectives: firstly, to model the cultural resilience after a given abrupt shock; secondly, to seek empirical testing of the models with archaeological case-studies. Adopting and adapting state-of-the-art analytical techniques that have been developed over the last two decades to study the relationship between demography, enviroment and cultural loss CLUES harnesses the computational power now available to run numerical models using the archaeological and cross-cultural databases such as Human Resources Area Files. CLUES is highly interdisciplinary, combining numerical and analytical modelling from a wide suite of fields, using tools developed to model cosmological datasets, data science, archaeological and anthropological data extraction and complex systems. This ambitious project will study culture aiming to forecast the requirements to achieve a general measure of the shock-induced tipping-points of culture. This is highly relevant at a global and European scale. At planetary scale, climate change and environmental degradation will bring to the tipping-point many vulnerable systems. In Europe, many rural areas and whole member states, are losing large amounts of population due to m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Agent based engineering in a cost estimation model for composites (ECOMP)'.

assistant: **Objectives**

The scientific challenge of this project lies in the application of agent-oriented software engineering to cover the real need of computing time and cost estimates in the expanding market of composite designs, as well as assisting designers in evaluating cost reduction strategies based on advanced computing techniques, which can be easily and readily accessed and used by SME's in their efforts to remain at the forefront of technological developments and to be well-positioned to compete on the global scene . The technical objectives of this project lie in the development, verification and validation of a web-based multi agent-based infrastructure that will assist composite manufacturers, equipment and tooling manufacturers, product designers and process engineers in developing new and better products, optimising processes, choosing equipment configurations and materials from a wide range of suppliers by providing them with a tool to assist them in evaluating cost reduction strategies so that they can con fidently make decisions early on during the design phase. Initial market research will be required to identify the needs, technological level, foreseen benefits, etc. of potential users of the proposed technology. This will be achieved through an extensi ve mailing (ordinary mail and via Internet) and personal interviews. The knowledge base will span the production tasks of materials selection, process selection, and process design and will encompass the experience of seasoned designers as well as theore tical models based on first principals. Composites technology knowledge will be gathered mainly from partners and RTD performers. The research seeks to capture the human solving knowledge used in composites, organise this knowledge and other numerical comp uting required
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Hygrothermal properties of carbon fibre reinforced composites (HYGROTHERM)'.

assistant: **Concept**

Carbon fibre reinforced polymere composites have a great potential as structural materials for aeronautics, aerospace, automotive and marine industry since they exhibit outstanding stiffness and strength to weight ratio, and therefore lead to significant reduction of energy consumption. However, the material properties are strongly influenced by the moisture diffusion within the polymeric matrices. The objectives of the project are to establish methods for the investigation of moisture effects on CFRP supporting process optimization and set up of new production technologies and to provide testing facilities and methods for the determination of the moisture influence on CFRP for materials qualification procedures in industrial environment. The testing methods and results will directly benefit the industrial partners in terms of cost and quality of products and contribute to materials development for e.g. satellites and vehicles.- High resolution facility for the measurement of the Coefficient of moisture expansion in vacuum environment at ambient temperature- Assessment of the THS-Transient Hot strip-method for the measurement of the thermal conductivity of CFRPs considering moisture effect- Verification of MR imaging for the detection of moisture in polymere composite materials, description of diffusion mechanism and estimation of diffusion and relaxation rates- Measurement results for electron beam cured carbon fibre reinforced polymer composites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The rules of miRNA-target interactions' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Micro RNAs (miRNAs) are short regulatory RNA molecules which modulate the levels of RNA and proteins in cells.Understanding the role of miRNAs in health and disease is a field with high engagement in molecular biology and biomedicine, with over 50 000 scientific articles published in the past 5 years (PubMed search “microrna[MeSH Terms]”).However, predicting their molecular targets is still a major unsolved challenge, and the state-of-the-art bioinformatic solutions for this task remain far from perfect. First, the task requires an exceptionally high accuracy and precision, as it can be compared to looking for a few hundred needles in a haystack: a few hundred targets among hundreds of thousands of transcripts. Second, the true mechanism of target binding is still unknown, which necessitates the use of heuristic approaches - ones that seem to work often enough, but are not necessarily related to the way miRNAs actually find their targets.   The aim of this project is to use bioinformatic methods to gain more knowledge about the mechanisms of miRNA-target interactions. We will approach this problem from several angles: 1) Using the deep learning methodology recently developed by the host group (miRBind), which reaches a single nucleotide resolution in its predictions; 2) Analyzing the interactions from an evolutionary perspective; 3) Developing a customized pairwise alignment algorithm combined with a dedicated statistical methodology. The Researcher will benefit from this project by gaining experience in the field of genomics in a multidisciplinary, collaborative environment.In the future, the results of this project will enable creating knowledge-driven machine learning models for improved prediction of the molecular targets of miRNAs, which will facilitate the fundame
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Implementation studies in four regions of the EU for power from biomass att he scale of 1 to 5 MW' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Objectives The objectives of the project include: - at each of the four selected sites (in southern England, Scotland, central Portugal and Piemonte in northern Italy) a survey of fuel resources, an assessment of planning, environmental and social issues, selection of conversion and other equipment, an examination of the potential for sales of electricity and waste heat and the preparation of reports, including implementing plans. - the associated dissemination of results nationally, within the whole EU and internationally. Technical Approach The project will be organised on three levels: - project co-ordination - overview and dissemination - to draw together and report on common themes identified below - site studies, which will focus on the detailed assessment of implementation studies in four regions Expected Achievements and Exploitation An implementation plan for the construction and operation of each proposed biomass-fuelled power station will be established. Sources of project finance, and the criteria for lending, will be identified. The risks inherent in the projects will be evaluated. Operating costs and revenues will be calculated. The partners will disseminate the results of this project within the member states of the European Union, to the relevant people within the energy professions and trade associations, in networks with utilities, research institutions, building professions and architects, municipalities, regional and national authorities, universities, industry and agriculture. In addition to the normal contractors' meetings of the JOULE programme, special seminars and workshops will be held to publicize the reports widely, including a major international seminar, self-funding apart from the inputs of the partners, towards the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DOLORisk: Understanding risk factors and determinants for neuropathic pain' (DOLORisk).

assistant: **Concept**

Neuropathic pain (NP) is common (population prevalence of 7-8%) and will present a rising health burden in the future. NP results in significant morbidity, reduces quality of life and has a major deleterious impact on health in aging. The reason why some subjects develop neuropathic pain and others do not following the same injury is not known. The exact nature of risk factors for NP and their interaction are currently poorly understood and will be the focus of this project. We will establish an international consortium of leading researchers in the field of NP (DOLORisk consortium) involving members of established academic European consortia studying pain/genomics and neuropathy as well as the SMEs Neuroscience Technologies and Mentis Cura. The project will be highly translational and the starting point will be the study of patients with NP or at risk of developing NP. Specific objectives will be to:1) Identify the influence of demographic factors, environmental/societal and clinical factors on the risk of developing and maintenance of NP2) To apply modern genomics to validate (using a targeted approach) and find novel (using genome wide association) genetic risk factors for NP. 3) Use tissue samples and patient derived cells from Biobanks to validate of molecular pathways contributing to chronic pain in patients. 4) To determine if patient stratification using physiological (sensory profile, endogenous analgesic mechanisms and nerve excitability) and psychological factors  can predict NP risk and progression. 5) Development of a risk model/algorithm for (severe) NP, combining measurable genetic and environmental factors. Our aim is to understand pain pathophysiology in terms of risk factors and protective mechanisms ranging from molecular pathways to societal impacts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Minerals Policy Guidance for Europe' under Horizon 2020.

assistant: **Concept**

MIN-GUIDE is a project addressing the need for a secure and sustainable supply of minerals in Europe by developing a ‘Minerals Policy Guide’. The key objectives of the project are (1) providing guidance for EU and MS minerals policy, (2) facilitating minerals policy decision making through knowledge co-production for transferability of best practice minerals policy, and (3) fostering community and network building for the co-management of an innovation catalysing minerals policy framework.This will be achieved through a systematic profiling and policy benchmarking of relevant policy and legislation in Europe, which includes the identification of innovation friendly best practices through quantitative indicators and a qualitative analysis country-specific framework conditions, as well as through the compilation of minerals statistics and reporting systems. These insights will form the basis for developing an interactive, tailor-made online ‘Minerals Policy Guide’. Another key feature of the MIN-GUIDE project will be knowledge co-production for minerals policy decision makers through Policy Laboratories exploring these best practice examples along the whole mineral production value chain (exploration and extraction, processing, recycling and mine closure). Furthermore, MIN-GUIDE will facilitate the building of a sustainable minerals policy stakeholder network through this knowledge co-production and utilization in Policy Laboratories as well as through three major Conferences. These Conferences will explore the minerals governance framework, work on recommendations for promoting innovation along the whole minerals production value chain, and put it into the wider context of the circular economy.  The MIN-GUIDE project and in particular the dissemination of the ‘Minerals P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'IND2016: KETs as drivers for the future of industry' (IND2016) targeting Horizon 2020.

assistant: **Abstract**

The European Key Enabling Technologies (KETs) strategy is important for the European global competitiveness, the creation of jobs and the European growth. Focusing on the development and valorisation of these KETs is crucial to this strategy. The industry-centred LEIT-NMBP part of Horizon 2020 is instrumental to the support of four of the six KETs: Nanotechnologies, Advanced Materials, Biotechnology, Advanced Manufacturing and Processing. The Work Programme (2016-2017), LEIT-NMBP focus on the valorisation of KETs. One of the activities supported by the European Commission are “events of a major strategic nature” such  as  conferences organised within the framework of the EU presidencies to create better synergy between initiatives launched by the Commission and by the Member States. This proposal is developed within the framework of the Dutch EU-Presidency (2016) and aims at the organisation of an international conference on Industrial Technologies. The main focus of the conference is the impact of KETs on the future of industry, that emphasizes the application of new and innovative technologies in the field of manufacturing to prepare the European industry for the future. Within this conference, the Dutch strategy on Smart Industry will act as the focal point to enhance the momentum to enter into a new manufacturing era in Europe. The overall aim of the conference is to co-develop the European agenda for the new industrial revolution and review the EU research agenda(s), to enhance the competitiveness of the European manufacturing industries. The conference will be held in the Netherlands in 2016 and last 3 days with an expected number 1250 participants over 30 nationalities from divers target groups (research, industry, private investors, policymakers and education).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'European forum on population ageing research management'.

assistant: **Concept**

This accompanying measure is intended to create a European-level coordination process that will enable the Community to obtain the maximum added value from its research in the field of population ageing. The project seeks to develop synergies between the key action on ageing and national and international research programmes; to improve research communication; to promote cooperation in ageing research; to stimulate new interdisciplinary research; and to promote a dialogue between science and citizens in this field. The end results will be clearer research priorities, closer collaboration between research programmes and a more efficient and effective approach to ageing research in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Geospatial based Environment for  Optimisation Systems Addressing Fire Emergencies' (GEO-SAFE), addressing dissemination and exploitation.

assistant: **Impact**

In EU and Australia, every year thousands of square miles of forests and other lands burn due to wildfires. These fires cause important economic and ecological losses, and often, human casualties. Both EU and Australian governments are aware of how crucial it is to improve wildfires’ management and containment . Scientists from different specialties, both in EU and Australia, have already developed methods and models in order to  improve the management and decision process  pertaining to preparedness and response phases in case of bushfire. The present project, named Geospatial based Environment for Optimisation Systems Addressing Fire Emergencies (GEO SAFE), aims at  creating a  network enabling the two regions to exchange  knowledge, ideas and experience , thus  boosting the progress of wildfires knowledge  and the related development of innovative methods for dealing efficiently with such fires. More precisely, the GEO SAFE project will focus on developing the tools enabling to set up an integrated decision  support system optimizing the resources  during the response phase, through:• Developing a dynamic risk cartography of a region with regard to the possibility of a wildfire. The task will involve data collection (satellite and remote sensors),  risk analysis and  development  of a tool   enabling to forecast fire extension i, and in particular to predict  fire and risk evolution during the response phase• Designing and testing a resource allocation tool for the response phase using the dynamic risk cartography. One of the problems to consider will be the resource allocation for securing key places (schools, hospitals, ….) given time dependent constraints. Problems will be identified through connections with final users, and the proposed solutions will be tested o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling a widespread DNA integration process critical for AMR propagation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The IntegrAMR project aims at unravelling a widespread DNA integration process that plays a critical role in the propagation of antimicrobial resistance (AMR). In alignment with the societal needs, the project will focus on a pathogen ranked as a high priority by the CDC and WHO, Acinetobacter baumannii. This pathogen is capable of natural transformation, a process allowing bacteria to take up exogeneous DNA for incorporation in their own genome. By unravelling the molecular mechanisms of DNA integration during natural transformation, this study will address how this conserved recombination process can alternatively favor or counteract the spread of AMR islands. This knowledge is crucial to understand how bacterial populations evolve and adapt rapidly to clinical treatments.The research will use a multiscale approach, from structural molecular biology to single-cell and multicellular systems. It will use customized next-generation sequencing, genetics, microscopy and mathematical modeling.To complement the scientific work, the project includes training and communication activities. Open access practices implemented in the dissemination of the results will maximize impact.This work will contribute to the global fight against AMR, advancing molecular microbiology, and fostering responsible research practices. The outcomes will not only enhance scientific understanding but also support the development of new strategies for AMR surveillance, benefiting both the scientific community and public health.Overall, the project will allow the candidate to pursue their desired career perspectives and apply to teaching or R&D positions, where microbiology and genomics expertise are in demand.


**Keywords:** Homologous Recombination, Natural Transformation, Multidrug resistance, Hori