RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Infection mechanisms of Escherichia Coli by bacteriophage T5, studied by cryo-electron microscopy'.

assistant: **Concept**

The project proposed here aims at understanding the infection mechanism of bacteria by phages. I will focus my attention on a tailed phage: T5. A global molecular and cellular analysis will be carried out. Electron microscopy techniques including single particle analysis in vitro and electron tomography in situ will be used to analyze the first steps of phage infection.First of all, molecular mechanisms for the anchoring of the T5 phage onto its membrane receptor and for DNA injection will be proposed. To this end, electron microscopy experiments followed by single particles analysis of proteins and complexes of proteins from the tip of the phage tail will be performed. Moreover, it has been recently shown that both phage fixation into its receptor and DNA ejection occur preferentially at the poles or at the septum of the bacteria, for several combinations of bacteria and phages. The correlation of the localization of the receptors and the fixation sites with the organization of the cytoskeleton will be tested by a cellular analysis by electron tomography.Eventually, I intend to understand the mechanisms which lead to the recruitment of the cellular machinery of E. Coli to the purpose of expressing phagic proteins and therefore repressing the expression of the bacterial genome.  A structural study in vitro will dissect the role of the different actors (RNA polymerase, phagic supposed transcription factors and phage promoteurs) for expressing the phagic proteins instead of the bacterial ones.This project will be carried out in a multi disciplinary environment. It relies on the expertise of the host lab in virology and involves cutting edge techniques in biochemistry and electron microscopy (single particle analysis and tomography) for which I will bring my knowledge. Dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Legitimacy, Financialization, and Varieties of Capitalism: Understanding Sovereign Wealth Funds in Europe' (SWFsEUROPE), addressing dissemination and exploitation.

assistant: **Impact**

The number and size of sovereign wealth funds (SWF) has grown substantially in the last decade, leading to an unsettled debate regarding their legitimacy in the global political economy. Some suggest they represent the (re)emergence of state-led capitalism subject to geopolitical motivations that threaten free markets. For others, SWFs represent a source of long-term patient capital capable of mitigating market short-termism. Either way, SWFs challenge the norm, particularly in the West, that financial markets are spaces of exchange for non-state actors. In three complementary and interdisciplinary work programmes the SWFsEUROPE project will explain the evolving and variegated pattern of ‘sovereign fund capitalism’ in Europe, developing a new theory of the relationship between states and global finance. First, the project breaks new ground by explaining and theorizing how the legitimacy of SWFs as commercially oriented investors is performed when they are still entities of the state. No study has critically examined how legitimacy is performed via mechanisms such as the International Forum of Sovereign Wealth Funds and the Santiago Principles, or the growing evidence of collaboration with cognate institutional investors (e.g. pension funds). Second, this projects seeks a multi-layered explanation of the uneven pattern of investment flows and stocks of foreign SWFs into European countries through hypothesis testing of aggregate investment data with different theories of national-institutional variety, coupled with a comparative analysis of the bilateral investment-promotion relationships of investment-receiving countries. Third, the project will compare the growth and development of European SWFs. There is no comparative study exploring why some states are sponsors of an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards an understanding of carbohydrate recognition calcium-mediated - synthesis and studies of interactions of oligosacharides in cell-cell adhesion process' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content The aims of this proposal is to study the molecular basis of carbohydrate-carbohydrate interactions recently proposed as mechanism for adhesion and recognition of normal and tumoral cells. Specific types of glycosphingolipids (GSL) and acidic proteoglycans are involved in this process. The research project will incorporate: (a) The synthesis of oligosacharides, epitopes in the cell adhesion process in sponges. (b) Determination of the tridimensional structure by NMR and molecular simulations. (c) Physical-organic studies on relevants interactions. (d) Studies of adhesion by atom force microscopy. This work is a part of a more ambitious programme on the molecular basis of important natural processes of carbohydrate recognition through investigations on synthetic model and natural systems. The work should lead to a better understanding of carbohydrate recognition for influencing biological processes. Training content (objective, benefit and expected impact) Synthetic skills and understanding of intermolecular interactions are specially important in this area of biological chemistry. A young scientist involved in this programme will have the opportunity to be trained in a multidisciplinar research area. Links with industry / industrial relevance (22) Tumor-associated GSL antigens have been used in the development of antitumoral vaccines. New structures of glycosphingolipids and oligosacharides involved in adhesion process are, therefore, targets for cancer therapy and control of cell proliferation. Actually, the host institution has an industrial collaboration in research in a related area of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Assessing Legacies of Past Human Activities in Amazonia'.

assistant: **Innovation**

Amazon forests contribute vital ecosystem services, including maintaining biodiversity (>10,000 tree species) and storing large amounts of carbon. Amazonia also features prominently in global climate, carbon, and vegetation models, which assume tropical forests are effectively pristine and that past human disturbance mimicked natural processes. It is now evident that recurrent human disturbance of Amazonia, like fire and deforestation, were significant in some areas. Since those disturbances likely modify subsequent vegetation dynamics - including temporarily increasing forest capacity to absorb carbon - the emerging paradigm of human disturbance is a challenge to global ecological understanding. The focus of my project is thus to reliably determine whether human disturbances occurred in locations that form the basis of global models. A key expected outcome is to either legitimize or force revision to these models of carbon sequestration potential in Amazonia.I will innovatively integrate ecological, paleoecological, archaeological, chemical and biogeographic analyses to assess the degree to which past human disturbance drives the diversity patterns and carbon dynamics observed in modern Amazonian forests. For key long-term sites across Amazonia, I will quantify the: i) time since the last fire, ii) past fire frequency, extent and intensity, iii) past vegetation change in the presence and absence of human activity, and iv) continuity of past human activity over the last 1000 years. My results will provide the first quantification of local-scale recovery processes exceeding 100 years in tropical forests, and will determine if observed forest dynamics are driven by disturbances that occurred before modern ecological surveys began. I will then quantify the extent to which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scalable and Quantum Resilient Heterogeneous Edge Computing enabling Trustworthy AI' in the context of a Horizon Europe call.

assistant: **Objectives**

SMARTY invokes a cloud-edge continuum, made from heterogeneous systems, that protects data-in-transit and data-in-process in order to offer a trustful fabric to run AI processes. The securitization occurs by employing novel accelerators for quantum resilient communications, confidential computing, software defined perimeters and swarm formation, offering multiple layers of security. Semantic programmability and graph-management open the door to drag-and-drop approaches in deploying services in a fast and reliable manner.SMARTY is proposed within the context of different key sectors in Europe : automotive, fintech, telco and industrial settings; the technology proposed in SMARTY will be matured within the lifetime of the project and tested through five use cases. SMARTY is supported by large European industry players and well as by 13 SMEs which will seek a visible platform to develop their products and gain visibility towards high-growth. SMARTY’s major suppliers and OEMs and reputable academic partners provide a great opportunity for these 13 SMEs to mature their technologies in a challenging but safe environment. The results of SMARTY are applicable to different vertical sectors and can be transported to different use cases. Strong synergies with existing efforts in the area of edge computing, European processors and trustworthy AI are envisioned and planned within SMARTY.


**Keywords:** edge computing, postquantum cryptography, confidential computing, software defined perimeters, graph knowledge, semantic programming, artificial intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Micro-meta-structures for computational sensors with built-in memory' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Sensory input in integrated systems is expected to increase with the entrance of AI and Internet-of-Things, requiring systems to become efficient and autonomous. The proposed research aims to introduce and study a new type of smart structure, dubbed meta-structures (MS), composed of repeating a unit cell to create a structure with new abilities such as multistability, non-volatility, and configurability. Such structures can be used to design autonomous sensors with built-in memory and computational abilities, allowing the formation of a new class of smart micro-electromechanical systems (MEMS) with edge computation and in-memory programming (IMP). In the aggregate, such smart sensors can lessen the dependency on a CPU and increase the autonomy of an overall system, while enabling distributed and parallel computations. Current MEMS-based structures are mono- or bistable, and as such are limited to registering one or two values in a sensor/mechanical memory/logical gate. However, recent studies have shown that an MS can break free from a two-bit structure. Indeed, in a recent breakthrough, we have shown that in the presence of electrostatic actuation, a micro-MS becomes multi-valued, with three stable equilibria, thus opening a gateway to a paradigm shift that goes beyond the study of new structures, to the formation of new class of MEMS. This new class of MEMS will be able to incorporate mechanical-based computation with IMP capabilities. Such an unconventional approach has the potential to augment traditional capabilities, introducing new abilities such as reduced leakage and power consumption, reconfigurability, decreased footprint, as well as compatibility with harsh environments (i.e., high temperatures or electromagnetic radiation), as well as reversible computing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding the molecular principles governing mRNP architecture' in the context of a Horizon Europe call.

assistant: **Objectives**

Eukaryotic messenger ribonucleoprotein (mRNP) particles are the functional entities that carry genetic information to the protein synthesizing machinery. These ribonucleoprotein complexes are dynamic and diverse, as highlighted by the copious number of proteins and transcripts identified in global proteomic and transcriptomic studies. However, little is known about the composition and architecture of individual mRNPs, and how changes in mRNP structure relate to their function or to dysfunction. The GOVERNA project will address this gap in knowledge by purifying specific mRNPs and delving into their molecular and structural arrangement. With our preliminary data serving as a springboard, the project combines genomic tagging engineered to maintain the most physiologically relevant conditions, biochemical methods developed to preserve the integrity of transient ribonucleoprotein assemblies, and mass spectrometry and cryo-electron microscopy to identify the composition and architecture of mRNPs. We will zoom-in on a set of paradigms in RNA biology that not only sample the breadth of mRNP diversity, but are also powerful model systems for linking structural information and biological function. We will investigate the molecular features in the three-dimensional organization of nuclear mRNPs from S. cerevisiae and of translationally repressed mRNPs in early developmental stages in D. melanogaster and X. laevis. For mRNPs undergoing active translation, we will investigate the transitions of human beta-globin mRNPs in the course of a surveillance process connected to disease. By studying these examples, we will glean fundamental insights into global principles governing the packaging of mRNPs and the remodeling of their three-dimensional features throughout a transcript’s life-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Signaling Pathways Controlling Patterning, Growth and Final Size of Drosophila Limbs' in the context of a Seventh Framework call.

assistant: **Objectives**

Developmental biology seeks not only to learn more about the fundamental processes of growth and pattern per se, but to understand how they synergize to enable the morphogenesis of multicellular organisms. Our goal is to perform real-time analyses of these developmental processes in an intact developing organ. By applying a vital imaging approach, we can circumvent the normal limitations of inferring cellular dynamics from static images or molecular data, and obtain the real dynamic view of growth and patterning. The wing imaginal disc of Drosophila, which starts out as a simple epithelial structure and gives rise to a precisely structured adult limb, will serve as an ideal model system. This system has the combined advantages of relative simplicity and genetic tractability. We will create several innovations that expand the current toolkit and thus facilitate the detailed dissection of growth and patterning. A key early step will be to develop novel reporters to dynamically and faithfully monitor signaling cascades involved in growth and patterning, such as the Dpp and Hippo pathways. We will also implement quantification techniques that are currently being set up in collaboration with an experimental physicist, to deduce, and alter, the mechanical forces that develop in the cells of a growing tissue. The large amount of quantitative data that will be generated allow us derive computational models of the individual pathways and their interaction. The focus of the study will be to answer the following questions: 1) Is the Hippo pathway regulated spatially and temporally, and by what signaling pathways? 2) Do mechanical forces play a pivotal controlling role in organ morphogenesis? 3) What are the global effects on growth, when pathways controlling patterning, cell compe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Research work for a virtual power-train system simulation platform' in the context of a Sixth Framework call.

assistant: **Objectives**

The project relates to 1D system simulation and refers to the following key words: System simulation platform, Customized Simulations, Software engineering, Automotive engineering and Collaborative design. This project proposed by IMAGINE aims at investigating innovative solutions permitting the development of a Virtual Powertrain System Simulation Platform based on AMESim.The Automotive Industry has a need for a platform to:- increase exchanges between project teams actors;- face exponential increase of systems complexity with growing integration of mechanics, hydraulics, electronics, embedded software components;- cut development costs for current and future clean vehicles. On this basis, the original and innovative idea of the 'Virtual Powertrain' research work aims at:- creating a single common model for system simulation supplying customized models;- covering powertrain development needs from preliminary design, component detailed design, development of the control strategy and ECU validation phase.The IMAGINE company, want to setup a partnership with the 'Energy and Environment Protection Research Centre' of the University 'Politehnica' of Bucharest to welcome three research fellows, for two years, who will explore key technologies for the success of the 'Virtual Powertrain'. Research work will focus on physical modelling, numerical and computer science issues.For the research fellows, it will be the opportunity to acquire to acquire skills in domains other than their own speciality by being involved in a multi-discipline research project, interact with industry and apply their skills to complex industrial problem; publish scientific papers and being involved in a high tech SME with world wide profile.The ToK should enable IMAGINE to create a long term partnership
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional Electrical Contacts to Two-Dimensional Materials with Tunable Interfacial Oxides' (ProTOC).

assistant: **Innovation**

Two-dimensional (2D) van der Waals (vdW) materials are promising for future nanoelectronic devices. However, their performance is often hampered by the presence of a large number of defects at metal/2D material interfaces. The project ProTOC will extend the applications of atomic layer deposition (ALD) to engineer functional electrical contacts in 2D nanoelectronic devices using interfacial transition metal oxides (TMOs) of controlled stoichiometry and electronic properties. ALD-grown TMOs, vanadium and titanium oxides, are explored as interfacial layers that are vdW-bonded to 2D material MoS2 on one side and chemically bonded to the metal electrode one the other side. ALD allows for precise control of the oxide composition in order to tune electronic properties, such as work function, dielectric constant, and defect concentrations. The electronic properties of ultrathin ALD-oxides of different compositions and their complex interactions with 2D materials, which in turn affect transport, will be investigated in a combined effort using 2D field-effect transistor (FET) transport measurements, spectroscopic methods, and scanning probe microscopy techniques. The band alignment at the contacts can be adjusted by changing the composition of the ALD-grown layers, which may provide a new route to engineering desired contact behaviour over a broad range from rectifying or low resistance ohmic, depending on the end application. This contacting scheme will be exploited to achieve both p- and n-type conductance in MoS2 FETs, which is key for logic applications and difficult to achieve with 2D materials. This project will benefit from the complimentary knowledge and experience of researcher, who is an expert in device design, fabrication, and advanced scanning probe methods, as well