RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Rapid Production of Large Aerospace Components', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SMD is a near-net system that allows complex parts to be built directly from the CAD model with minimum finishing. The system creates components in layers, depositing weld material without the need for tooling. Complex parts can be made with improved material properties, and it is possible for hybrid components to be created. The time and material savings are expected to make SMD an attractive option for the manufacture of large aerospace parts. Although capable of making parts, the process requires a great deal of manual intervention and control.Research will focus on maintaining and controlling the process, maintaining the quality of the microstructure and developing process models (Finite element, process, mechanical, mechatronic) respectively of the 6-axis robot controlled motion in working conditions and of the weld material deposition/solidification process so that a wider variety of materials can be used in the future. Other areas of interest include the environmental benefits, the cost benefit and impacts of using the process. SMD is ideal for use in prototype production as well as in manufacturing, eliminating the need for tooling and shortening development lead-times, reducing aircraft development and operating costs. Near-net manufacture will slash part costs as currently up to 90% of the material is removed.Operational costs will be affected, as SMD will allow complex, hollowed components to be manufactured that couldn't be produced in any other way, allowing lighter aircraft to be built and reducing fuel costs. It uses no tooling (flexible tooling), will be automated through RAPOLAC research, uses advanced methods to reduce costs (raw materials, machining time, cutting fluids, dies and moulds, tooling) and has low to zero harmful emissions. The objectives w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Filling the gap: Strategies for the processing of unbounded dependencies cross-linguistically' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Much psycho- and neurolinguistic research has been dedicated to filler-gap dependencies, identifying the cognitive mechanisms and brain structures underlying the processing of these structures. However, this research tended to focus on languages with one shared property, namely the lack of grammaticized resumptive pronouns. The objective of the proposed project is to expand the empirical scope of the explorations of unbounded dependencies by investigating the processing of these constructions in Hebrew, a language in which gaps and resumptive pronouns alternate (relatively) freely. The project will focus on two interrelated research questions:1. Are differences between the grammars of languages reflected in processing? Specifically, are the same processing strategies employed in languages with and without resumptive pronouns? For example, it has been shown that in English, once the syntactic processor identifies a filler, it engages in active search for a possible gap. Given that in Hebrew some fillers are not associated with gaps but rather with resumptives, does the parser in this language actively construe gaps like its English counterpart, or does it adopt a 'wait and see' strategy?2. Are resumptive pronouns easier to process than gaps, as is sometimes assumed in the literature, or are they in fact harder to process, since their processing invariably includes a misguided extra step, namely the (unwarranted) construal of a gap? Or does their processing involve some aspects which are easier (e.g. accessing their antecedent), and some which are harder?These issues will be addressed using techniques and paradigms proven successful in the study of online sentence processing, e.g. cross-modal lexical priming and self-paced reading, as well as event-related potentials, uti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'From haplotype to phenotype: a systems integration of allelic variation, chromatin state and 3D genome data' to be submitted under Horizon 2020.

assistant: **Abstract**

High-throughput sequencing methods are breaching the barrier of $1000 per genome. This means that it will become feasible to sequence the genomes of many individual and create a deep catalog of the bulk of human genetic variation. A great task will lie in assigning function to all this genetic variation. Genome wide association studies have already shown that 40% of all loci significantly associated with disease are found in intergenic, supposedly regulatory regions. One of the current challenges in human genetics is that variants that affect expression on a single allele cannot be directly linked, because only have genotype information, rather then haplotype information. The overarching aim of the project is to resolve haplotypes in order to identify genetic variants that affect gene expression. We will do this in three sub-projects. In the first main project we will use 3D genome information gathered from Hi-C experiments to haplotype the genomes of six lymphoblastoid cell lines. We will integrate these data with chromatin profiling and RNAseq data in order to build integrative models for the prediction of gene expression and the effect of genetic variation on gene expression. In the second project we will perform haplotyping the breast cancer genes BRCA1/2 in a large cohort of individuals that come from families with a high-risk of hereditary breast cancer. Allelic imbalance in BRCA1/2 expression levels are known to be associated with an increased risk for breast cancer. We will aim to find genetic variants that are associated with a decreased allelic expression of BRCA1/2 to improve breast cancer risk assessment. Finally, we will develop a novel tool to study 3D genome organization of single alleles, which will allow us to identify how individual alleles are organiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Research on PHOENIcian-punic sites in Andalusia with eXperimental Unmanned Aerial System with Lidar'.

assistant: **Innovation**

Among the most recent remote sensing methodologies applied in archaeological research are proximity analysis carried out with UAS (Unmanned Aerial System). Commonly referred to as drones, they are rapidly evolving instruments that allow the use of different acquisition sensors, such as LiDAR (Laser Imaging Detection and Ranging). This is a tool that makes it possible to scan not only objects, but also entire landscapes and to observe the ground surface (virtually cutting through vegetation and man-made elements), thus enabling better topographical reading and the identification of archaeological features. LiDAR mounted underneath aircraft has already proven to be a valuable tool for archaeological research in the past, although it is little used due to the high costs and low resolution of the digital terrain models produced in which only the topographical macro-elements are highlighted, such as fortifications and urban districts.Now, with the drastic reduction in prices and the miniaturization of hardware, it is not only possible to equip a drone with LiDAR, but also to obtain data at a centimetric resolution that allows even micro-topography to be appreciated. Despite its considerable potential, there is little pioneering research on the subject and a lack of manuals on the use of these LiDAR UAS and the interpretation of the data.Therefore, the aim of PHOENIX-UASL is the study and experimentation of these new technologies on some case studies that are well suited to the investigation, in order to grasp their potential and limitations; the results of which will be complementary to the classic studies of landscape archaeology and aimed at the diachronic reconstruction of places. Specifically, it is intended to target research at some important archaeological sites in An
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional anatomical molecular optical screening' (FAMOS) targeting Seventh Framework.

assistant: **Abstract**

Biophotonics offers low-cost, non-invasive, accurate, rapid alternatives to conventional diagnostic methods and has the potential to address medical needs with early detection and to reduce the cost of healthcare. FAMOS will develop a new generation of light sources with step-changes in performance beyond the state-of-the-art to radically transform biophotonic technologies for point-of-care diagnosis and functional imaging. This will enable optical diagnostics with superior sensi-tivity, specificity, reliability and clinical utility at reduced cost, heralding an imaging renaissance in Europe.FAMOS addresses optical imaging from molecular over (sub)cellular to individual organs, with no gap in the arsenal of diagnostic tools for medical end-users. The world-class multidisciplinary FA-MOS team of 7 leading academic institutions and 10 top SMEs has unique complementary knowledge of optical coherence tomography, adaptive optics, photoacoustic tomography, coherent anti-stokes Raman scattering, multiphoton tomography as well as swept-source, diode-pumped ultrafast and tuneable nanosecond pulse lasers. Combinations of some techniques will offer multi-modal solutions to diagnostic needs that will exploit and enhance the benefits of each modality. FAMOS technologies have wide applicability, but our specific focus is on diagnosis in ophthalmol-ogy and oncology. Partnerships with leading innovative clinical users will enable preclinical evalua-tion.The objectives of FAMOS are:\tDevelop new light sources with a step-change in performance (2-3 times more compact and up to 3-4 times cheaper diode pumped Ti:sapphire, 4-10 times faster swept sources and tuneable nanosecond pulse sources)\tIntegrate these with optical imaging for a step-change in diagnosis (2-5 times better resolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoherence in Superconducting Devices' under Seventh Framework.

assistant: **Concept**

A hallmark of quantum mechanics is the coherent superposition of states of a system, but uncontrolled interactions between system and environment lead to loss of coherence. For applications such as quantum computation and quantum metrology coherence must be preserved, and to obtain long coherence times a promising approach is to capitalize on the quantum properties of superconductors. Indeed many superconducting devices based on Josephson junctions are under active experimental investigation. This project has two main goals: to advance our theoretical understanding of decoherence processes in such superconducting devices and to explore how to limit their detrimental effects. The initial focus will be on the intrinsic decoherence due to quasiparticles, the elementary excitations in superconductors, especially under non-equilibrium conditions. The peculiarities of single, few, and many junction systems (such as transmon, phase and flux qubits, Cooper pair pumps, fluxonium, etc.) will be addressed in detail. Then the effectiveness of quasiparticle trapping schemes will be studied. In addition, interactions with photons will also be considered: on one hand, photons are used to manipulate these systems, on the other they cause decoherence, and the optimal balance between these two conflicting aspects will be sought. By suggesting new ways to reduce decoherence, the results of this project can contribute to the improvements in the performance of superconducting devices that will enable their practical use for quantum computation and metrology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Rights and Liberties in a Comparative Perspective: A Cross National Analysis of Discrimination Against Sexual Minorities'.

assistant: **Objectives**

This interdisciplinary research project will attempt to develop a new theoretical paradigm for the understanding of rights and liberties in a comparative perspective, with a particular emphasis on the rights and liberties of sexual minorities. The innovative aspects of the research are in its attempt to form a new theoretical framework, the collection of original data and the use of a combination of cutting edge methodological approaches to empirically test the theory. The proposed project aims to contribute in several ways to the discipline of political science, the study of law and public law, sociology and to policy studies. This research project’s main goal is to explain the creation of rights and liberties in a comparative perspective by analyzing the systematic effects of variables running the gamut from the origins of the legal system and the nation’s level of globalization to modernization and political inclusion in the polity. In terms of productivity, the ultimate goal is to produce a book manuscript and a series of journal articles based on the novel theory, data and methods. In addition, an international conference will be organized on the topic, where researchers from Europe, Israel and elsewhere will present their work and discuss substantive and methodological issues. Lastly, a student exchange program with institutions in Europe and the United States will be established and additional grant applications will be based on the products of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Binary Evolution and Low-Level Accretion' (BELLA).

assistant: **Innovation**

Although X-ray binaries constitute to the brightest X-ray point sources in our Galaxy, a peculiar subgroup is orders of magnitude fainter in the X-rays than the general population. These sub-luminous X-ray binariesmay harbor unusual donors, tracing rare binary evolution paths, and represent a relatively poor explored regime of accretion. This proposal aims at elucidating the nature of this tantalizing population of X-ray binaries to advance our understanding of binary evolution and accretion flows occurring at low rates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Quorum sensing and regulation of virulence factors in salmonella infection'.

assistant: **Objectives**

The human pathogen Salmonella remains a significant ongoing threat to worldwide public health. Although major advances have been made with respect to the understanding of Salmonella-specific host pathogen interaction, the nature and the regulation of bacterial virulence effectors directly responsible for the host response remains elusive. Quorum sensing constitutes a bacterial cell-cell communication system in which bacterial secreted auto-inducing molecules signal and trigger changes in gene expression. Such systems can act as global regulators of virulence like in Staphylococcus aureus. In Salmonella typhimurium, the quorum sensing auto-inducer AI-2 is the final product in a biosynthetic pathway involving the AI-2 synthesis encoded by the luxS gene. Recent reports indicate that AI-2 plays a role in the coordination of virulence in Escherichia coli and Streptococcus pyogenes . However , the role of quorum sensing mechanisms in Salmonella pathogenicity has not been investigated yet. With this project, I intend to explore the role of AI-2 in regulating Salmonella virulence. A luxS-null mutant will be constructed and compared with the parent in its ability to infect and colonize the host by using cultured human epithelial intestinal cells, cultured mouse macrophages and a mouse model of systemic infection. Effects of AI-2 in regulating expression of Salmonella pathogenicity islands (SPI-1 and SPI-2)-encoded virulence factors including the components of the type III secretion systems will be analyzed in vitro and in vivo. Finally, the function of AI-2 as a regulator involved directly in infection and stimulation of host signaling cascades will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '6th Symposium on Nonlinear Control Systems - NOLCOS 2004' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Non-linear control systems have been developed to a core field in control engineering with an advanced mathematical theory and many applications that place high demands on quality, productivity, precision and robustness. The need of non-linear control methods is related to thenonlinear behaviour of most technical and non-technical dynamical systems and processes, which have to be described by non-linear mathematical models. Acknowledged as the major international gathering of leading experts, industrialists and academics in the field of Non-linear Control Systems NOLCOS 2004 aims at strengthening contact between academia, especially young researchers and industry to build up new networks and cultivate existing relations. The mutual exchange within the conference will make an important contribution to promoting the future co-operation between sciences and industry on an international level and therefore strengthen the European Research Area. High-level speakers will expose the global spectrum ofNonlinear Control Systems, state-of-the-art situation and development directions. European R&Dorganisations as well as industry will benefit and find fresh impulses for reflection and innovation in vital field of European Economy. The NOLCOS 2004 is meant as a forum for young scientists such as graduate, doctoral and post-doctoral students from all over Europe. They are given the opportunity to introduce their research ambitions and their scientific work to an international expert audience, to learn about state-of-the-art topics and to engage into discussions with highly renowned researchers from academic and industry. Furthermore a large number of elements are especially dedicated to young researchers. Physicists and engineers need more than a solid basis in science and engineeri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effect of ALlopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome' (ALBINO) targeting Horizon 2020.

assistant: **Abstract**

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and consequently about 5-20.000 infants per year in Europe.Hypothermic treatment became the only established therapy to improve outcome after perinatal hypoxic-ischemic insults. Despite hypothermia and neonatal intensive care, 45-50% of affected children die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective interventions, beside hypothermia, are warranted to further improve their outcome.Allopurinol is a xanthine oxidase inhibitor and reduces the production of oxygen radicals and brain damage in experimental, animal, and early human studies of ischemia and reperfusion.This project aims to evaluate the efficacy and safety of allopurinol administered immediately after birth to near-term infants with HIE in addition to hypothermic treatment.Beyond this primary objective, the project will provide information on the effect of hypothermia on pharmacokinetics of drugs with a similar metabolism as allopurinol in neonates. Furthermore it will give the opportunity to further develop and validate biomarkers for neonatal brain injury using advanced magnetic resonance imaging, biochemistry, and electroencephalogramms, which will then be available for future studies testing neuroprotective interventions. Finally, this trial will extend our knowledge about incidence of and risk factors for perinatal asphyxia and HIE possibly enabling generation of more preventive strategies for the future.


**Keywords:** off-patent medicine