RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Effective Delivery of Nucleic Acid Therapeutics via Designed Nanocarriers' (NATPRIME).

assistant: **Innovation**

Delivery of Nucleic Acid Therapeutics to desired organs has become the current challenge of biotechnological applications. Advancements on the chemical synthesis or targeting ligands, formulation of complex lipid systems, and their bioassays are essential to establish new gene therapies. Therefore, the main aim of NATPRIME DN is to establish a multidisciplinary training network on the emerging topic of nanoparticle-based adjuvants to deliver nucleic acid therapeutics (NAT). In the last decade, great efforts have been spent on the development of synthetic strategies for the creation of RNA based therapies/vaccines, and these efforts have been acknowledged by the Nobel committee in 2023. The next important step is targeted delivery, which is to carry NATs to the desired tissue. For this purpose, various nanoassemblies, i.e lipid nanoparticles, polyplexes, liposomes, that are modified with targeting ligands will be utilised to encapsulate NATS. Antibodies, peptides, glycans, and glycopolymers open up greater possibilities in the precise targeting of nanoparticles to desired organs/tissues/cells. The combined molecular toolbox of targeting ligands, charged lipids, helper lipids and PEG-replacement lipids need a high-throughput formulation-screening to ensure increased uptake of such particles in the desired organs. 15 interdisciplinary  researchers will be trained on the design, synthesis, and characterisation of such complex targeting ligands, their formulation in nanoparticles, and their utilisation in the nucleic acid based treatments. Last but not least, biophysical understanding of molecular interactions of formulation components will bridge the gap between fundamental and applied research while broadening the horizon of ESRs from an academic lab to good manufacturing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of cellular regulators and pharmacological inhibitors of endophilin-A3 to modulate its endocytic functions' (ModulEndoA3) targeting Horizon Europe.

assistant: **Abstract**

In addition to classical clathrin-mediated endocytosis, mammalian cells have clathrin-independent endocytic (CIE) mechanisms. Among others, the BAR domain proteins, that sense and induce membrane curvature, are key players in CIE. In particular, the BAR domain protein endophilin-A3 (endoA3) drives CIE of the cell adhesion molecules CD166, L1CAM, and DICAM, with implications in tumour progression and viral infection. The regulation, mechanism, and functional implications of this recently-identified endoA3-mediated CIE route remain poorly characterized. In this context, I propose an interdisciplinary project combining cell biology, chemical biology, and virology approaches to substantially advance our understanding of endoA3-mediated CIE. The first research goal is to identify cellular regulators (kinases, phosphoinositides) that modulate endoA3-mediated endocytosis. In parallel, this project aims at identifying small molecule inhibitors that selectively inhibit the endocytic functions of endoA3. Subsequently, the cellular regulators and pharmacological inhibitors identified in this project will be used in cells, to modulate endoA3-mediated endocytosis and study the impact on cellular functions. Emphasis will be put on cancer cell properties and endocytic viral particle entry. Together, this project will generate high-quality fundamental knowledge on the mechanism and function of endoA3-mediated CIE. Moreover, the identification of modulators of endoA3 endocytic functions will provide valuable biological tools for the study of this recently-identified CIE route in physiology and pathology. Lastly, the identification of selective pharmacological inhibitors may pave the way towards the development of innovative antiviral and anti-cancer therapeutics targeted at unconvention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Modelling of ageing in concrete nuclear power plant structures'.

assistant: **Innovation**

MAECENAS will develop a comprehensive reliability-based analysis assessment tool to determine the risk of an unacceptable reduction in the structural safety of reinforced PCCV and PCPVs as a result of operational and environmental ageing effects.For the first time a complete analysis capability will exist that considers the complex moisture transport, creep, shrinkage and fracturing processes under elevated temperature for concrete suffering multi-axial stress states. This can lead to a step-change in the interpretation of condition and assessment of appropriate repair strategies.Test data on the behaviour of aged concrete will be gathered to create a thermodynamically consistent constitutive theory. The project will involve close collaboration between leading academic institutions and senior engineers from within the nuclear industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Service Annotations for User Interface Composition' (ServFace).

assistant: **Innovation**

Service-oriented architecture (SOA) promise to break former monolithic applications into pieces that can be distributed across several systems and that can even be offered by external service providers. With the loose coupling of services in combination with established standards, SOA enables dynamic, flexible applications which can always change rapidly by integrating new services as well as old legacy systems even across technological platforms as well as company boundaries. The development costs can be reduced significantly by reuse of services and by dynamic reconfiguration of service compositions. With the focus on B2B scenarios, new applications can easily be built by selecting and combining services. However, SOA approaches have also a high potential to improve the development of interactive applications, e. g. in business processes or B2C scenarios. But despite of this potential, the development of interactive applications, i. e. the development of corresponding user interfaces and its flexible combination together with functional services is not properly reflected in current Web Service standards and research approaches and thus, remains a major challenge and requires substantial development resources. Reasons are missing hints for user interface generation like description of parameter semantics and explicit UI descriptions that could be used to at least partially automate UI development and to select appropriate services in service repositories. Another challenge is the design of service interfaces appropriate for composing services and a correspondent UI for independently developed, autonomous interactive services. Methodologies are required that describe how to define services user interfaces and especially how to select the right granularity for such inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Untangling the dry limit for microbial life in rock-inhabiting communities of US Western drylands' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The effects of global warming are particularly pronounced in drylands, leading to their fast degradation and hampering the capacity to support active life. In an era of fast desertification, DRYLIFE seeks to identify those conditions that determine the dry limit for microbial life in the US Western drylands where a temperature increase up to 3°C associated to increases in aridity is expected by the end of the century. DRYLIFE will answer the key question using endolithic communities, simple and stable microbial communities dwelling inside rocks ubiquitous in drylands worldwide, as paradigmatic model system. In hyper-arid regions, in particular, once the threshold of dry tolerability for plants and soil microbes is crossed, endoliths represent the latest possibility for life, regulating water retention and nutrient cycles and creating positive feedback for ecological successions. DRYLIFE will be carried out in leading US and EU research laboratories by undertaking an interdisciplinary approach to address fundamental questions about how tiny microbes may have global-scale impact. This bottom-up project will combine amplicon sequencing, shotgun metagenomics, micro-environmental monitoring, geomicrobiology, and machine learning. Data generated will be translated, for the first time, into predictive models to better understand endolithic communities functioning and adaptations under global change, addressing a key knowledge gap. While my previous pioneering studies on Antarctic endoliths laid the basis for DRYLIFE, this Action will broaden my research and training skills and widen my professional networks, leading to a critical career development boost as an independent researcher. DRYLIFE will likely have the potential to improve projection of future climate impact on dryla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'New integrated system to automatically record impact of interictal epileptic activity on behavior, reactivity, and consciousness of epilepsy patients'.

assistant: **Objectives**

Behavior, reactivity and consciousness of epilepsy patients may be unpredictably impaired by seizures. For one important aspect in the daily lives of epilepsy patients, driving, international and national guidelines exist. These guidelines for the fitness to drive require worldwide a period of seizure freedom. In addition, a compatible electroencephalography (EEG) recording is required for vocational drivers in many countries and for all traffic participants in few countries including Switzerland. It’s about the occurrence of epileptiform EEG potentials in-between seizures that are not perceived by epilepsy patients and not visible to observers, called interictal epileptic activity (IEA). Detailed EEG compatibility specifications have however not been formulated. In an interdisciplinary approach with neurology, medical electronics engineering, behavioral  neurosciences, and informatics, we aim at developing the first integrated system that automatically records the impact of IEA on behavior, reactivity, and consciousness in epilepsy patients, called DigRTEpi Test. This test should support physicians in their assessment of IEA effects on reactivity and thus provides objective and standardized support in the decision on EEG compatibility and the fitness to drive in clinical practice. The new system will circumvent digital latencies by computers and software, record patients’ effective reaction times and thus will open a new dimension of accuracy. A new open-source video-EEG synchronization and compatibility with various commercial EEG recording devices will grant user-friendliness. Patients will benefit from a better understanding of the impact of IEA on their daily activities of life because IEA effects can be made plausible to them by reaction time prolongations, and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimization of Perennial Grasses for Biomass Production' to be submitted under Seventh Framework.

assistant: **Abstract**

OPTIMA will integrate an ambitious biology system approach for perennial grasses such as switchgrass, miscanthus and giant reed in the Mediterranean environment. Moreover the perennial species cardoon, which has been proven to be particularly adapted to the Mediterranean climate, will be used as a control species.The main objective of the OPTIMA project is to identify high-yielding perennial grasses for the Mediterranean area, within optimized production chain that will provide stable source for both biomass and new plant derived bio-products. OPTIMA will explore the potentialities of perennial grasses on underutilized or abandoned marginal lands.An interdisciplinary approach involving physiology, biotechnology, and agronomy, socio-economical and environmental analysis at different scale levels will be undertaken with the aim at tackling specific bottlenecks of perennial grasses in the Mediterranean area and to create alternative end-use chains. OPTIMA approach has been to link the research proposed here by including industrial end-users in the project. This should allow the output of this research to develop in a commercial context as rapidly as possible the new findings.The major goals of this multidisciplinary network are to evaluate the existing genotypes; to characterize and deliver novel species; to deliver sustainable crop management practices (sowing/planting strategies to reduce the use of pesticide and increase biomass on the first year establishment, cultivation under salinity conditions and/or water deficit,  reducing losses during harvest); to evaluate the industrial production of bioenergy and added value bio-products; to assess the environmental impact through an integrated assessment of sustainability criteria, to disseminate the achieved findings at dif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HISTORICISING THE PRIVATISATION OF HEALING KNOWLEDGE' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

PrivHealth aims to establish the first history of the process of privatisation of healing knowledge. Combining methods from history of knowledge and tools from computational history, PrivHealth demonstrates how a legal framework that guaranteed that healing knowledge could be kept as a private asset arose from colonial exploitation and knowledge circulation between 1700 and 1900. The results of PrivHealth will provide a nuanced historical framework that will both shape academic historical debates and inform discussions over intellectual property rights in the medical and pharmaceutical fields at a societal level.


**Keywords:** history of knowledge, healing, medicine, privatisation, 1700-1900, computational history
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding Serotonergic Regulation of Working Memory' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Functional integrity of the prefrontal cortex (PFC) is essential for higher ‘executive’ functions such as working memory (WM). Serotonin (5-HT) modulates GABAergic neurotransmission in the PFC through different 5-HT receptor subtypes that are selectively expressed in distinct GABAergic cell types. Altered GABAergic neurotransmission in the PFC of patients suffering from schizophrenia and depression is believed to be central to their pathophysiology. Currently available treatments targeting 5-HT signaling have addressed different mental health symptoms but typically not cognitive capabilities. Therefore, characterizing the causal role of distinct GABAergic cell types on circuit activity is a critical step in understanding the circuit mechanism of WM.This proposal focuses on the role of 5-HT in the regulation of inhibition in cortical activity and their consequences in influencing WM maintenance. I will simultaneously image the electrical activities of pyramidal and distinct GABAergic interneurons while well-trained mice execute a delayed two alternative forced choice (2AFC) task to read out WM during the delay period. Imaging will be performed in both wide-field and two-photon imaging mode to record cortical activity at the mesoscopic (cortex-wide) and local (PFC) levels, respectively. I will combine optical imaging with optogenetic stimulation/silencing to manipulate GABAergic interneurons in the PFC and serotonin release in the dorsal raphe (DR) during the execution of the 2AFC task. Additionally, I will use a mouse model of schizophrenia that is known to exhibit WM deficits to correlate possible alterations in serotonin signaling during cellular-level WM maintenance with WM performance at the behavioral level. This could allow us to understand why many psychiatric tre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Superconducting and ferroelectric two-dimensional electron gases (2DEGs) at oxide interfaces.' (2DEGs) under Horizon Europe.

assistant: **Objectives**

In the project “SURFER”, we will demonstrate the coexistence of antagonistic properties namely superconductivity (SC) and ferroelectricity (FE)” and the enhancement of superconducting transition temperature (TC) through coupling with FE in oxide two-dimensional electron gases (2DEGs). So far, this coupling has almost only been observed in bulk oxides and in thin films of doped SrTiO3 (STO) where no ferroelectric switching is possible due to the three-dimensional distribution of carriers. The origin of SC and enhanced TC due to coupling between FE and SC is still not clarified, which might be because only one material (STO) system has been studied.  In SURFER, we aim to realize ferroelectric and superconducting oxide 2DEGs with enhanced superconducting properties that are also switchable with FE present in these systems. With this aim, we will explore three new oxide 2DEG systems that have not been studied so far which will be fabricated based on different ferroelectric materials (1. STO thin films. 2. BaTiO3, and 3. Niobium (Nb)-substituted KTaO3) by growing on top a thin metal or oxide overlayer. In addition to the experimental realization of oxide 2DEGs hosting such interesting properties, this project will also help us to gain a clear understanding about the origin of SC and enhanced TC, due to FE and SC coupling in oxides which is a longstanding question by investigating the properties of these material systems in detail.


**Keywords:** oxide 2DEGs, ferroelectricity, superconductivity, coexistence of ferroelectricity and superconductivity, thin films
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The hybrid syntactic typology of Sinitic languages' in the context of a Seventh Framework call.

assistant: **Objectives**

This project proposes to carry out the first large scale investigation into the typology of Sinitic or Chinese languages, broadening its horizons beyond Standard Mandarin to consider the major parameters in the grammatical makeup of this language taxon with respect to the neighbouring language families of East and Southeast Asia.   The principal objective is to examine and seek explanations for the apparent hybrid typology of Sinitic languages which reveal a perplexing mixture of head-final and head-initial features and consequently pose several striking counterexamples to classic Greenbergian word order correlations. The theoretical issue involved is to question accounts which purely rely upon areal diffusion to explain this, without considering language-internal development, in particular syntactic change, as an interacting component.   Complicating research in this field is the fact that Standard Mandarin is generally the main, if not, only point of reference for Sinitic languages in typological studies in the West, while until recently it persisted as the primary object of analysis in Chinese linguistics in general. Thus, a macroscopic survey of the ten branches of Sinitic is first proposed to describe their fundamental syntactic properties and word order correlations in detail. Second, the project sets out to challenge and refine the hypothesis of a North-South typological dichotomy for Sinitic languages based on areal principles and advocated by Hashimoto and Norman.   To this purpose, the research plan also includes a comprehensive analysis of the grammar of  Waxiang, a language spoken in remote northwest Hunan province and chosen to represent the transitional zone of Chinese languages in central China . Significantly, this language shows characteristics of an in