RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Molecular Computing and Intractable Problems'.

assistant: **Concept**

We will consider new computational possibilities provided by computing with biomolecules. Biocomputing (also known as DNA-computing or molecular computing) is a new interdisciplinary area of science where computer science, chemistry, biology, and physics meet, that promises revolutionary changes in computations in the near future. It aims at developing new devices and systems to manipulate information operating at atomic or molecular scale on the basis of biological, chemical, electronic, photonic and/or mechanical principles.We will investigate both theoretical and practical aspects of some important models of biocomputing. In particularly we will focus on distributed splicing systems and membrane systems, and as well as on Hybrid Networks of Evolutionary Processors. We will consider the frontier of intractability (for example, undecidability) in problems for them, in order to better understand their computational possibilities (universality, efficiency, complexity and so on). These investigations permit approaching the creation of a real bio-computer and efficient parallel algorithms for solving some hard computational (intractable) tasks, for example, Post Correspondence Problem (PCP Problem), Satisfiability Problem for Propositional Formulas (SAT problem) and others.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FINfet structures for FLASH devices' (FINFLASH).

assistant: **Concept**

The FinFLASH project aims to study a new cell architecture to overcome the scaling limits of FLASH memories beyond the 28nm technology node (year 2015 and after). The new idea is to evaluate the potentialities of the FinFET, one of the non-classical advanced MOSFETs that provides a path to CMOS scaling to the end of the RoadMap, for FLASH memory application. Main challenge will be the optimisation of the device structural design to achieve NVM functionalities. Additionally, the introduction of new materials will enable new operating principles that may provide new behaviour and functionality beyond the constraints of classical FLASH memories.The FinFLASH approach is promising both for stand-alone NVMs, due to the extremely compact memory cell size, and for the embedded ones, due to the intrinsic compatibility of the FinFLASH process with the one of FinFET logic devices.The main objectives will be:1) Study on the most promising charge storage media and device designs;2) Evaluation based on single cells and arrays of FinFLASH devices;3) Definition of program/erase schemes at ultra-short channel lengths;4) Development of comprehensive and predictive models both at the device and circuit level;5) Simulation and optimisation of FinFLASH devices using TCAD tools.During the first year preliminary evaluations of multi-gate device structural design will be made by advanced 2D/3D TCAD simulations. At the same time, the development of the critical technological modules will be treated. Both deep UV and e-beam lithography will be adopted to realize devices, on Si-bulk and SOI, with minimum size of 25nm x 25nm.A detailed electrical and microstructural evaluation of the devices will be performed. During the second year of the project, a second run of devices will be done, allowing fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy'.

assistant: **Concept**

The Integrated Infrastructure Initiative for Neutron Scattering and Muon Spectroscopy (NMI3) comprehensively integrates all aspects of neutron scattering and muon spectroscopy in Europe. It will be a cornerstone of the European Research Area, making significant contributions to the science research base that underpins European technological development.The NMI3 brings together 23 partners from 14 countries, including 11 research infrastructures, together with other interested organisations. The NMI3 will advance the integration of the field, and the effective use and development of these research infrastructures, by providing:  12 different Access Activities offering approximately 5000 beam days of access to 150 instruments, for 1700 users who will carry out 900 projects; 8 Joint Research Activities on enhanced instrumentation and techniques, involving 50 research groups; 4 Networking Activities to widely disseminate the results, expand the user community and plan for the future.Particular emphasis is given to: Integrating user organisations and their representatives within the decision making management; Activities to disseminate the results of the NMI3 widely and rapidly through the partners and beyond; Activities to encourage future or greater participation of smaller countries, or countries with small or no facilities; Activities to develop the relationship to, and integration with, complementary experimental techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Minimal submanifolds in Arbitrary Geometries as Nodal sEts: Towards hIgher Codimension' (MAGNETIC) targeting Horizon Europe.

assistant: **Abstract**

The goal of this research proposal is to advance the calculus of variations of area in codimension higher than one, specifically existence and regularity of its critical points (minimal submanifolds) and properties of its gradient flow (mean curvature flow). These are central objects in mathematics since three centuries and contributed to the birth of geometric analysis, geometric measure theory, and calculus of variations. Their (non-)existence often reveals deep links between small-scale geometry (curvature) and large-scale structure (topology). While the hypersurface case is by now well understood, with several deep results in the last two decades, very little is known in codimension at least two, especially for unstable submanifolds not minimizing area. Several projects will focus on the intimate link between area and some well-known physical energies: phase transitions are understood to give diffuse approximations of hypersurfaces, while vortices in models of superconductivity relate to codimension two submanifolds. An energy proposed by me and D. Stern in this context is the abelian Higgs model, which I plan to use to extend the Lagrangian mean curvature flow past singularities and to relate stability and regularity of minimal submanifolds, which are two long-standing questions in geometric analysis (among other projects), by exploiting the much richer structure given by the PDEs solved by critical points of this energy. I will also look at candidates in codimension three and higher, inspired by energies from gauge theory and others of GinzburgLandau type, relating stability and minimality in critical dimension and attacking other basic open questions. Finally, I will also work on another set of projects exploiting parametrized varifolds, a variational object pion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'E-vclo' in the context of a Fourth Framework call.

assistant: **Objectives**

The virtual Clinical Laboratory (VCL) concept, in which hospital laboratories participate, uses a conversion procedure to recalculate results to a uniform reference method with minimal increase of variance. This results in a consistent data set with uniform reference ranges and comparable values, enabling a central laboratory output" by "local laboratory input". When hospital laboratories paricipate in a VCL, they are better equipped to participate in large European clinical trials with minimal disturbance of their routine testing services. Benefit can be taken from the high quality facilities at the investigator site, while continuity of patient care will be secured. the VCL-concept was implemented in The Netherlands in 1995 as an initiative of the Dutch Society for Clinical Chemistry (NVKC) and the Dutch Foundation for Quality Assessment of Clinical chemistry Laboratories (SKZL). Extension of this Dutch initiative within the European Union will be a prerequisite to have VCL to obtain a meaningful position amongst regular large Clinical Laboratory Organisations (CLO's). With sufficient presence in the major European countries, i.e. the UK, France and Germany, and with a network with the sponsors in the Trans-Atlantic markets, the VCL concept will be of additional value to the large multi-centre phase IIb and phase III projects. This proposal is meant to explore the possibilities for extension of the VCL-concept in Europe and to identify the suitable partners to act as a local VCL-organisation. Software has to be developed in order to collect laboratory data from the local hospital information-systems to the central VCL computer. With the VCL -concept hospital laboratoires and hospital physicians will have better chance to participate in large clinical trials and streng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Efficiency of ctl response induction by dc-subsets'.

assistant: **Concept**

Dendritic cells (DC) are the professional antigen presenting cells of the immune system that instruct and control the activation of B and T lymphocytes, the mediators of specific immunity. DC are highly mobile cells and by their sequential migration from peripheral tissues to lymphoid organs they serve as sentinels of the immune system. Their extremely potent capacity to initiate and modulate immunity is currently exploited to fight infectious and autoimmune diseases as well as cancer. It is now well established that multiple distinct DC subsets exist. Moreover, it is well appreciated that the DC subset and the microenvironment a DC encounters in the periphery, determine the type of immune response that is induced, ranging from a TH1 or TH2 response to regulatory T cells and immune tolerance. The purpose of this project is to investigate the potential of different DC-subsets to induce an effective CTL mediated anti-tumor immune response in vivo and to characterize the type and magnitude of the induced immune response. The plan of investigation consists of comparing DC-subsets with respect to their ability to:1) migrate into lymphoid tissues and their localization within these tissues (using green fluorescent protem (GFP)-DC and Indium-111 labeled DC);2) induce an immune response against the foreign antigen ovalbumin (OV A) or the self antigen Tyrosinase Related Protein-2 (TRP-2),3) their vaccine efficacy in tumor models (B 16-OVA model and the fully autologous B 16- TRP-2 tumor model). We shall determine the quality and the magnitude of the induced responses using MHC-tetramers and cytokine assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Next generation, off-the-shelf, non fratricide-directed, CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

R/R T-ALL remains a major clinical challenge. Despite improved survival rates thanks to intensive chemotherapy regimens, event-free (EFS) and overall (OS) survival remains <70% and R/R T-ALL has a particularly poor outcome. There are currently no potential curative options for R/R T-ALL beyond hematopoietic stem cell transplantation (HSCT) and conventional chemotherapy, which is linked to large trade-offs in toxicities. Sadly, >90% of patients with R/R T-ALL/LL ultimately die. Strategies targeting T-cell malignancies using immunotherapies (including CARTs) remain challenging because of the shared expression of target antigens between normal and malignant T-cells, ultimately leading to life-threatening immunodeficiency due to T-cell aplasia and fratricide of CARTs, which limits their therapeutic efficacy.Here, we propose a unique and innovative approach to address this unmet clinical need based on the dual targeting of two specific antigens with expression restricted to T-cell lymphoblasts. Our consortium aims to provide a cost-effective immunotherapeutic alternative for most of the R/R T-ALL patients by the dual targeting of two tnon-fratricide antigens using our scalable, HLA-independent, allogenic, off-the-shelf, proprietary platform of CORD-GDT cells, thus overcoming the challenges of harvesting sufficient numbers of functional effector T cells from multi-treated patients with advanced disease while avoiding the toxicities derived from other shared antigens between healthy and malignant T cells . Our strategy will be preclinically assayed using cutting-edge experimental models, and we will mature and scale-up the proprietary platform of universal CORD-GDT cells redirected against these two non-fratricide antigens, expected to provide superior effector features and co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Subjective well-being and fertility' to be submitted under Seventh Framework.

assistant: **Abstract**

The project is about subjective well-being (SWB) and demographic behaviour, with a particular focus on fertility in advanced societies, across time and space. The project is motivated by the fact that European and other advanced industrialized countries have for decades experienced below-replacement fertility levels, which are now posing dramatic challenges to ageing population structures. Cross-sectional and temporal variations in fertility remains an unsolved puzzle for current theories of below-replacement fertility. The argument put forward in this project is that SWB may be the missing link in the understanding of why countries differ so significantly in fertility.The project has a strong interdisciplinary perspective with the following aims:-to advance the understanding of the complex link between SWB and fertility, bringing together a longitudinal perspective with a comparative perspective;-to examine the role of policies, welfare provision and social norms operating at different levels, addressing possible policy measures that would improve the SWB of individuals and couples, leading eventually to increased fertility-to communicate findings and stimulate the academic and policy debate on how SWB matters for fertility, highlighting the relevance of SWB for future data collection efforts and the potential use of SWB for fertility projections;The project relies upon secondary data sources, both longitudinal and comparative in nature. The assessment of SWB and fertility requires statements about causality and interactions with the relevant context. By explicitly addressing the linkages between SWB and fertility in a systematic way, the project will address an important gap in the literature, helping to modify mainstream theoretical frameworks for the understanding f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Circuit mechanics of emotions in the limbic system' (EMOTIONCIRCUITS), addressing dissemination and exploitation.

assistant: **Impact**

Numerous studies established the role of the limbic system in fear and reward: it integrates sensory information, encodes emotional states and instructs other brain centers to regulate physiology and behavior. The limbic system, however, consists of many distinct and highly interconnected neuronal populations. Resolving how emotions are processed in this network at the level of single neural circuits remains a major challenge.As entry point into the complexity of emotion circuitry, we propose to study, in exemplary fashion, how fear, as the most basic paradigm for emotions, is processed in key limbic hubs. Genetic manipulation of brain circuitry with electrophysiological methods and Pavlovian conditioning in mice, are powerful tools to explore which and how individual circuits in these hubs control emotional states, and, in turn, how genes and psychoactive drugs modulate circuit activity, emotional states and behavior.We envision this ERC funded research to uncover general principles of the network organization of both emotions and behaviors. It is our hope that we contribute useful tools and methodological framework for investigating other brain functions in a similar manner.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Access to rights data via identification technologies optimisation' (ARDITO).

assistant: **Concept**

Everything is digital today in the creative industries value network. The production process, often the products, the supply chains, and the communication with end users.The digital world calls for fast and cross-border re-use of creative content in different contexts, at different levels of granularity, for different purposes.However there is a dark lacuna when it comes to the digital content value network – everything is digital except the actual functioning of the rights supply chains to enable such re-use. When users wish to re-use content, it is very hard to find information on who to ask for permission, which licenses are available, and on which terms and conditions.This is where the ARDITO project comes into play. The project vision is that any user should be able easily to access such rights information. To obtain this, we need a Rights Data Network (RDN), a network of connected e-infrastructures to automate the exchange of information about rights. We do not start from scratch. The Linked Content Coalition initiative has defined the framework. The RDI project has demonstrated how such RDN could implement the LCC framework; and the Copyright Hub has provided a first implementation of such principles.The time to go live with actual services is now. A group of SMEs, well established in different creative sectors (books, audio-visual and images), a research centre and the Copyright Hub Foundation decided to promote the ARDITO idea to accelerate the development of the RDN, through optimising a range of content identification technologies (watermarks, content recognition, DOIs) for use in the RDN, integrating them into the Copyright Hub ecosystem, and developing new services, ready to bring to the market.The services are varied but share the same vision: to be an acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Picosecond Infrared Laser for Scarfree Surgerywith Preservation of the Tissue Structure and Recognition of Tissue Type and Boundaries' (SUREPIRL), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research is based on a recent breakthrough in directly observing atomic motions during structural changes and in studying energy redistribution channels in liquid water on the femtosecond time scale. These studies provided the key insights that drove the development of a new laser concept for direct-drive laser ablation. By judicious choice of laser pulse parameters, it is now possible to selectively excite water molecules to act as a propellant to drive molecules into the gas phase faster than any other energy exchange mechanism or growth of nucleation sites to cause shock wave damage or other deleterious effects. With the resulting Picosecond Infrared Laser (PIRL) surgical tool, proof-of-principle studies have shown that it is possible to produce wound sizes at the fundamental limit of a single cell - with virtually no scar tissue formation. More than an order of magnitude reduction in the wound healing zone relative to the conventional scalpel has been achieved with complete healing. Equally important, the laser ablated molecules remain completely intact for determination of the tissue type. This is the first time it has been possible to drive intact proteins into the gas phase, in a matrix independent manner, for ultrasensitive detection using mass spectroscopy. The prospects for advancing both surgery and biodiagnostics to their respective fundamental limits of single cell precision and single molecule detection is within reach. This proposal represents a well coordinated effort involving medical researchers across a broad spectrum of disciplines to fully explore the applications of this new technology, from minimally invasive surgery with molecular signatures for feedback and on the fly guidance to prevent cutting critical structures, to in situ patho