RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of Myosin-X in filopodia elongation and axon guidance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Cell migration is a complex process that is central to many aspects of medicine and biological research: embryo development, tumour development (invasiveness and vascularization), and nerve regeneration after injury and stem cell migration. Migrating cells heavily rely on their ability to adhere to and extract information from extracellular molecules. For this purpose, they extend thin protrusions (filopodia) that probe the environment ahead of the cell. Due to fixation artefacts, these very thin and motile structures have proved difficult to analyse. Recent live cell imaging techniques offer new tools to elucidate how they form and understand their function. Integrins are transmembrane receptors of the extracellular matrix and regulate adhesion and migration by relaying external signals to the cytoskeleton. In neurons, integrins are also involved in several aspects of axon growth and guidance. Myosin-X (Myo10) was recently identified as an integrin-binding partner. Myo10 is a unique motor protein in that it not only binds to actin, but it also interacts with microtubules and several signalling molecules that are heavily involved in cell migration. Myo10 is found at the tip of filopodia and it influences their length and number. Interestingly, Myo10 is strongly expressed in neurons at the growth cone, the sensing tip of axons.This project is aimed at answering the following questions:- What role does Myo10 play in filopodia elongation? The implication of a possible vesicle docking and delivery function of Myo10 and the involvement of integrins will be assessed.- What role does Myo10 play in axon growth and guidance? Manipulation of Myo10 expression and its binding to integrins will be carried out in live neuroblastoma cells.Advanced live cell imaging techniques will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Online Mobile Communities to facilitate the Social Inclusion of young marginalised people' (ComeIn) targeting Seventh Framework.

assistant: **Abstract**

Young people are assets to development and potential agents of social change, yet youth exclusion is widespread and increasing across Europe. Such exclusion translates to unbearable costs both to the individual, being deprived of access to important assets, and to society, having to finance the burden of marginalised groups instead of benefiting from their productive potential.Through the concept of online communities, ICT has the potential to serve as a gateway to social inclusion. However, computer and internet access of marginalised young people are limited, raising the need to develop alternative methods to approach them through ICT.The main objective of ComeIn is to study and utilise mobile networks and telephones that are most commonly used by marginalised youth, as the main infrastructure for social inclusion. Using innovative real-time integrated communication video solutions, this project will develop a networked media platform that will give rise to mobile online communities, delivering interactive media content specifically aimed at marginalised youth.This approach combines the benefits of the online community concept with an inclusive approach, realised through the most abundant device used by marginalised youth in Europe – mobile phones.The goals of this exploratory project include:-Provide groups of marginalised youth with ICT based mobile online communities-Design and deliver content aimed to facilitate social inclusion of marginalised youth of various backgrounds-Analyse the impact of ICT and mobile network use by marginalised youth and make recommendations for future researchAbove the technological impact, such a programme will provide young people with knowledge, capabilities, networking and skills which will better their chances of becoming integrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synergistic Fouling Control Technologies' to be submitted under Seventh Framework.

assistant: **Abstract**

Marine biofouling, the unwanted colonization of marine organisms on surfaces immersed in seawater has a huge economic and environmental impact in terms of maintenance requirements for marine structures, increased vessel fuel consumption, operating costs, greenhouse gas emissions and spread of non-indigenous species. The SEAFRONT project will aim to significantly advance the control of biofouling and reduce hydrodynamic drag by integrating multiple technology concepts such as surface structure, surface chemistry and bio-active/bio-based fouling control methodologies into one environmentally benign and drag-reducing solution for mobile and stationary maritime applications. In parallel, a combination of laboratory-based performance benchmarking and end-user field trials will be undertaken in order to develop an enhanced fundamental/mechanistic understanding of the coating-biofouling interaction, the impact of this on hydrodynamic drag and to inform technology development and down-selection of promising fouling control solutions. This project aims to facilitate a leap forward in reducing greenhouse gas emissions from marine transport and the conservation of the marine ecosystem by adopting a multidisciplinary and synergistic approach to fouling control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spectroscopy of Spin Excitations in sub-100nm Magnetic Structures using High Electron Mobility Transistor Photodetection' (SPECTROSPIN), addressing dissemination and exploitation.

assistant: **Impact**

The increase in information storage in computer hard drives is the result of considerable effort towards the miniaturization of magnetic bits and the development of magnetic materials with suitable magnetic anisotropy.  As information access rates are now well into the GHz range, understanding the dynamics of spin excitations in confined geometries becomes important to solve the problem of cross-talk between bits and to reduce the energy cost of writing.  In small magnets, the surface modes of spin excitations increasingly dominate and lead to complex absorption spectra where quantum phenomena, such as tunnelling of the magnetization, become increasingly probable.  Established spin spectroscopy techniques such as Brillouin Light Scattering are unfortunately limited to sample sizes no smaller than the wavelength of light and also require a minimum volume of material to match the sensitivity of the detection apparatus.The present consortium will develop a novel spin spectroscopy technique that uses a high mobility two-dimensional electron gas as a photodetector of the stray magnetic field emanating from spin waves and other magnetic excitations.  This technique was experimentally demonstrated by the PI.  Spin Wave Photo-detection complements Brillouin Light Scattering by measuring spin excitations in individual magnets much smaller than the wavelength of light.  The technique is so sensitive that it detects the magnetization dynamics of individual magnets which eliminates spurious effects associated with averaging over arrays of magnets.  The purpose of the consortium is to group the research expertise and manpower of the three partners to develop exploit the full potential the photovoltage spectroscopy technique for probing ultra-small magnets and uncovering physical phe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TraffikGene-Tx: Targeted Peptide Carriers for RNA Delivery' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

TraffikGene-Tx: Targeted and Dynamic RNA Peptide Vehicles-Unmet Clinical Need and ProblemRare and complex genetic diseases lead to significant disability, death and associated cost burdens for society. Complex genetic diseases include cardiovascular diseases (CVD) and cancer, the two leading causes of death in the EU and up to 36 million Europeans suffer from rare genetic diseases. Nucleic acid therapeutics (NATs) represent a potential treatment, but they are hampered by the delivery problem. Systemically administered naked RNA is quickly degraded by endonucleases, can provoke adverse immune reactions and has off-target toxicity. Viral and lipid nanoparticle (LNP) delivery vectors have toxic side-effects and are difficult to produce and target.-The SolutionTraffikGenes RNA delivery platform is:Safe: biodegradable, non-immunogenic peptide carriers that cleave to avoid the detergent toxicity of LNPs.Targetable: beyond the liver, to the spleen, lungs and heart with excellent delivery to the cytosol.Scalable: Production is automated, simple and cheap.TraffikGene combines modular design with high-throughput screening which will feed into AI-enhanced SAR-based predictive vehicle design. This will accelerate and de-risk NAT drug development.-The ProjectTraffikGene will capitalize on the current breakthroughs in healthcare represented by NATs. RNA therapeutics (mRNA, saRNA, siRNA, lncRNA, miRNA) are now emerging driven by the success of mRNA vaccines and TraffikGene will deliver them to the tissues where they are needed. We aim to break new ground in the field of RNA, validate our delivery vehicles and start developing our pipeline to advance to the preclinical trial stage with therapeutic RNAs. We aim to launch our company of customised peptide carriers for any RNA medicine wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Diagnostic methods and reference panel of reagents for detection and typing of fish viruses.' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aims of the proposed study are:- To improve and harmonize research and development of biotechnological diagnostic procedures for viral diseases in aquacultured fish.- To investigate the genetic diversity among fish rhabdoviruses.- To establish an international database for available diagnostic reagents related to viral diseases in aquacultured fish.Specific objectives are:I) To produce and characterize virus specific monoclonal antibodies for diagnostic purposesII) To develop DNA probes and primers for hybridization and PCR assays for detection and typing of virusesIII) To generate an international database describing available reagents for diagnosis of fish virusesIV) To perform RNase protection assays and phylogenetic analyses of the fish pathogenic rhabdoviruses VHSV, IHNV, SVCV and ELTV in order to determine the extent of diversity among the genomic variants of the respective virusesV) To develop diagnostic kits for commercial useDissemination activities:A workshop will be organized for the evaluation, and standardization of diagnostic methods in fish virus diagnostics in Euope.Results will be published by submissions to international scientific journals and by presentations at scientific meetings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proteome profiling using plasmonic nanopore sensors' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

To date, antibody-free protein identification methods have not reached single-molecule precision. Instead, they rely on averaging from many cells, obscuring the details of important biological processes. The ability to identify each individual protein from within a single cell would transform proteomics research and biomedicine. However, single protein identification (ID) presents a major challenge, necessitating a breakthrough in single-molecule sensing technologies.We propose to develop a method for proteome-level analysis, with single protein resolution. Bioinformatics studies show that >99% of human proteins can be uniquely identified by the order in which only three amino-acids, Lysine, Cysteine, and Methionine (K, C and M, respectively), appear along the proteins’ chain. By specifically labelling K, C and M residues with three distinct fluorophores, and threading them, one by one, through solid-state nanopores equipped with custom plasmonic amplifiers, we hypothesize that we can obtain multi-color fluorescence time-trace fingerprints uniquely representing most proteins in the human proteome. The feasibility of our method will be established by attaining 4 main aims: i) in vitro K,C,M protein labelling, ii) development of a machine learning classifier to uniquely ID proteins based on their optical fingerprints, iii) fabrication of state-of-the-art plasmonic nanopores for high-resolution optical sensing of proteins, and iv) devising methods for regulating the translocation speed to enhance the signal to noise ratio. Next, we will scale up our platform to enable the analysis of thousands of different proteins in minutes, and apply it to sense blood-secreted proteins, as well as whole proteomes in pre- and post-metastatic cancer cells. NanoProt-ID constitutes the firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Protests in Sub-Saharan African countries'.

assistant: **Innovation**

This project aims to study mobilization in sub-Saharan African countries -with a focus on Nigeria and Zimbabwe- by investigating protest activities between the year 1995 and 2010. By articulating the social movement literature with African studies, the research aims to analyze the impact of the political context and the organizational structure on mobilization in such countries. In addition, it proposes to study the impact of a repressive political context on the organizational structure sustaining mobilization. Empirically, the research will first explore mobilization in various sub-Saharan African countries by using existing public opinion surveys (Afrobarometer Survey Series Data) containing information on individual engagement in protests and public demonstrations. To understand the impact of a repressive context on the organizational structure, it will then analyze protest events and actors involved in protests in Nigeria and Zimbabwe, both classified as repressive countries by international indexes. By specifically focusing on mobilization around the oil-related issues in the Niger Delta, in-depth interviews with main organizational actors will clarify the specific organizational resources necessary for the development of protests in a repressive context.Analyses of these data will privilege a mixed-method approach and will be elaborated through classical inferential statistics and qualitative techniques.The project is relevant for the Work Programme as it proposes a genuine mobility within the ERA and it promotes interdisciplinarity and intersectoriality, thus strengthening exchanges and networks among scientific communities. In addition, it aims to attract the interests by non-specialists on issues relevant for European policies.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantitative Large Scale Proteomics of Lysosomal Storage Disease' under Seventh Framework.

assistant: **Concept**

Lysosomal storage diseases (LSD) are a group of ~ 50 genetic disorders, which mainly affect children. LSDs are clinically heterogeneous but are frequently dominated by progressive neurologic deterioration. Most patients pass away after years of lingering illness. In general, the molecular pathogenesis of LSDs is still poorly understood. To gain insight into disease mechanisms the project investigates cellular proteomic alterations sequentially induced by increasing lysosomal storage. In vivo and in vitro models of selected LSDs affecting the nervous system will be investigated. Whole cell proteomes, subcellular fractions and tissues will be analyzed using quantitative large scale mass spectrometry based proteomic techniques employing stable isotope labeling based multiplex quantification approaches (TMT, iTRAQ, SILAC) and tandem mass spectrometry on an Orbitrap Velos mass spectrometer.Three model systems focusing on glial and neuronal cells will be analyzed: a) in vitro differentiation of  NG2 glia to oligodendrocytes under normal or sulfatide accumulating conditions as a model for metachromatic leukodystrophy (MLD); b) in vivo alterations occurring in the course of progressive demyelination in the peripheral nervous system of a mouse model of MLD c) a cell culture model in which consequences of increasing storage of ß-glucosylceramide in neurons will be examined as a model of Gaucher disease.Using the quantitative data, alterations in protein expression and phosphorylation will be identified, grouped and analyzed for up- and downstream interaction partners as well as biological processes they are involved in. This will be done for various levels of storage to understand the succession and possibly the hierarchy of events. These data will allow describing cellular conse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a Low-cost two Mw Two-bladed Wind Turbine' (LOWCOST2BLADE2MW).

assistant: **Innovation**

This project addresses the challenge of decreasing the cost of wind power in a way to make it economically viable for general use. The wind turbine is two-bladed, since the potential economy generally is better, since it is better suited for optimisation at high wind speed sites and since it is easier to handle offshore. The main objective of the project is to fulfil the economical goal set up in the Work Programme. Other objectives are to realise the compact sub-critical teetering hub and the yawing system that is based on teeter angle measurements (both patent pending). The design origins from the 1 MW Nordic 1000 which is the only large two-bladed wind turbine that is produced commercially today, with an excellent experience from operation of prototype and serial turbines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Industrial Data Services for Quality Control in Smart Manufacturing' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

i4Q Project aims to provide an IoT-based Reliable Industrial Data Services (RIDS), a complete suite consisting of 22 i4Q Solutions, able to manage the huge amount of industrial data coming from cheap cost-effective, smart, and small size interconnected factory devices for supporting manufacturing online monitoring and control. The i4Q Framework will guarantee data reliability with functions grouped into five basic capabilities around the data cycle: sensing, communication, computing infrastructure, storage, and analysis and optimization. i4Q RIDS will include simulation and optimization tools for manufacturing line continuous process qualification, quality diagnosis, reconfiguration and certification for ensuring high manufacturing efficiency, leading to an integrated approach to zero-defect manufacturing. The i4Q RIDS will be demonstrated in 6 Uses Cases from relevant industrial sectors and representing two different levels of the manufacturing process: machine tool providers and production companies. i4Q pan-European consortium entails Industrial partners: WHIRLPOOL (White goods manufacturer), BIESSE (Wood industrial equipment), FACTOR (Metal machining), RIASTONE (Ceramic pressing), FARPLAS (Plastic injection) and FIDIA (Metal industrial equipment); Implementers: TIAG (Industrial Communication Protocols and Standards), CESI (Machine tools, Advanced Materials, Micro-technology) and AIMPLAS (Thermoplastic and thermosetting plastic materials); Technology Providers: IBM (Information Technologies Company), ENGINEERING (Software and Services Company), ITI (Information Technologies Institute), KNOWLEDGEBIZ (Information Systems Company), EXOS (Operations Consulting Company); R&D partners: CERTH (Research Institute), IKERLAN (Technological Centre), BIBA (Research Institute), U