RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Purification of Water by Harvesting Solar Radiation in a Rare-Earth (RE)-ion Quantum-dot Glass Evaporator' (RE), addressing dissemination and exploitation.

assistant: **Impact**

High-quality supply of drinking water is essential for maintaining good health and environment. The quality of water-supply infrastructure symbolizes the progress and prosperity of a nation. Increasing population overburden and unpredictable climate change on earth is making drinking water resources scarce, consequently large parts of tropics and sub-tropics are affected adversely. For making pathogen/toxic chemical-free drinking water available, low-cost sustainable approach for water purification is essential, especially in the impoverished regions of the tropics and sub-tropics, where the sunlight is abundant.   In order to provide solution for this crisis of drinking water shortage, my Q.dot-PurE-WatER MC project focusses on exploiting quantum (Q)-dot rare-earth(RE)-ion-doped glass from waste phosphor lamps for re-engineering solar-energy harvesting water evaporator and filtration system, called the solar-still as demo. In a demo solar-still, the Q-dot paint layer will be applied for enhancing black-body absorption for heating water to above 95oC for killing pathogens. The solar-still will also store energy by utilizing the organic lauric acid phase change mixture for using heat after sunset. The evaporated water will be filtered through photo-sensitized nano filter for destroying vapour-transported pathogens and chemicals. My goal is to demonstrate favourable impact of solar-still for the purification of dirty water of Ganges River in collaborative research training activities at the IIT-BHU in Varanasi, India and the St. James Hospital and Water@leeds in Leeds UK. This demonstration will be achieved as a result of four training packages including impact pathways, spread over 24-months, which will include six 15-days short visits to Varnasi, India.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Multiparameter sensing for high sensitivity diagnostics using fluorescent and magnetic nanoparticles'.

assistant: **Objectives**

The objective of FLUOROMAG will be to(a) produce noble metal nanoclusters or nanodots, (NDs), and core-shell (CSs) nanoparticles by a new method using controlled electrochemical techniques that ensure very uniform size distributions and transfer of this technology to a dedicated SME who will scale up the synthesis of these nanoparticles for commercial production as well as supply the consortium with NPs for characterization of their extinction, fluorescent and magnetic properties and the further development of diagnostic tests.(b) devise conjugation strategies to couple biomolecules to noble metal NDs and commercially available quantum dots, (QDs) to produce probes that can specifically target macromolecules such as proteins and DNA/RNA in vitro and in cells and tissues. We will take advantage of ND electrochemical synthesis to introduce specific molecules in the shells that permit efficient derivatization and coupling to biomolecules.(c) develop multiparametric diagnostic assays using combinations of bioconjugated QDs and noble metal NDs as novel, fluorescent probes, and bioconjugated noble metal nanoparticles as extinction probes. The goal is to achieve high sensitivity (down to single virus detection) in molecular and cellular recognition. New Hepatitis C, Dengue Fever and breast tumor assays are proposed that will monitor several antigens in multiplexed kinetic and end-point determinations.  (d) develop a commercial, low-cost programmable array microscope (PAM) module for wide field microscopes with SME partner which utilizes a spatial light modulator to achieve high-speed sectioning and simultaneous measurement of multiple fluorescence modalities as a detection system for single and multiplexed diagnostic assays using nanoparticles developed in a-c for the health-c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Awash Baringo Correlation and Cyclostratigraphy: Human evolution and paleoclimate' (ABCCycle).

assistant: **Innovation**

Age control is central in the study of human evolution as most if not all major hypotheses in palaeoanthropology and archaeology critically depend on it. It is further generally assumed that adaptation to new environments was the catalyst to key biological and cultural innovations in our ancestral lineage. However, in most cases, a high-resolution temporal framework to test whether human evolution is driven by environmental and climate change is lacking. However, such a framework can be provided by astronomical dating or tuning.   ABCCycle (Awash Baringo Correlation and Cyclostratigraphy) therefore aims to i) construct a high-resolution astronomically-tuned age model for two key paleontological and archaeological localities in East Africa, using a novel combination of relative paleo-intensity (RPI) and rockmagnetic cyclostratigraphy in order to ii) critically test if climate and environmental change controlled the distribution and evolution of hominins in the East African Rift Valley.This project builds upon the magnetostratigraphic expertise developed by Mark Jan Sier (MJS) during his PhD and postdoc as well as his privileged access to the drilled sediment cores of several localities from the East African Rift Valley, including Baringo/Tugen Hills Barsemoi and North Awash Region. MJS will provide entirely new approaches to the chronological and environmental control of this region by applying an integrated cyclostratigraphic approach for geological dating and correlation as has been developed at the department of Earth Sciences of Utrecht University.


**Keywords:** rockmagnetic cyclostratigraphy, geochronology, human evolution, East Africa, ICDP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engaging citizens as agents of change for sustainable food system transition with a novel gamified educational citizen science platform' (FOODMISSION) under Horizon Europe.

assistant: **Objectives**

Developing a fair, healthy, and environmentally friendly food system represents a key priority of the European Green Deal. This is expressed in particular through the ‘Farm to Fork Strategy’, which recognises the need to empower consumers to make informed, healthy and sustainable food choices and to reduce food loss and food waste. FOODMISSION aims therefore to use multi-actor and inclusive Transformation Labs and blend citizen science, learning and gamification approaches to understand citizens’ food practices for initiating behavioural changes, and ultimately engage and motivate to accelerate the uptake of more sustainable food behaviour. The project objectives are the following: (1) Setting up Transformation Labs that will support the project through all its phases from co-design to uptake, (2) Design of a comprehensive citizen science data framework, collecting and processing citizen-generated data on their food practices and development of a technical data infrastructure and data visualisation tools to support data sharing and analysis, (3) Design of a citizen motivation and engagement framework for empowering individual and collective change, (4) Co-development of a gamified educational virtual platform prototype and its content and activities, (5) Piloting and evaluation of the gamified educational virtual platform in 6 European countries, (6) Promotion of FOODMISSION’s key exploitable results and their impact to engage citizens for fair, inclusive, healthy, and sustainable food system in Europe and uptake of the outputs beyond the project and consortium. FOODMISSION will further contribute to the Food 2030 pathways for action. The interdisciplinary consortium is composed of 10 members based in 8 European countries, bringing together universities, innovative comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Follow the PAIN: Novel Somatotopically-Based Integrative Approach to Study Mechanisms of Detection, Transmission and Perpetuation of Nociceptive, Inflammatory and Neuropathic Pain', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The worst of evils  - pain is one of the main reasons for seeking medical help. Chronic pain affects almost one fifth of the population of Europe and leads to exorbitant medical expenses as well as extreme suffering. Despite extensive efforts, effective pain treatment has remained elusive. Inadequate understanding of the mechanisms of pain prevents the development of effective therapies. In order to better understand pain mechanisms, a novel integrative approach is needed.  This approach should: to investigate the fundamental site of signal detection; the nociceptive terminals and to establish an understanding of the progression from peripheral nociception to central pain perception.  Our project aims to integrate analysis at different levels of pain perception in normal and pathological conditions in order to elucidate mechanisms underlying chronic pain.  Our approach propose to study pain related mechanisms along somatotopically define neuroaxis of vibrissae-barrel system.   Using this unique system where peripheral receptor directly corresponds to its central analyzer, we will first characterize noxious signal detection by single channels in individual nociceptive terminal.  We will follow propagation of nociceptive signal and monitor activity-dependent changes in corresponding circuits at trigeminal nuclei, thalamus and cortex.  We will study modulation in of synaptic connectivity in the spino-thalamo-cortical pathway in models of chronic pain.   This multi-disciplinary project will incorporate ground-breaking imaging techniques and state-of-the-art electrophysiological, histological and behavioural experiments to study pain-related mechanisms at the molecular and cellular levels as well as at the level of neuronal networks and behaviour.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rotifers as Vehicles for Epibiotic Bacteria' (RAVE).

assistant: **Innovation**

Non-trophic species interactions such as epibiosis are poorly studied and their impact on food web properties not easily quantified. Using rotifers and their attached bacteria, this project analyses two hypotheses on epibiosis in freshwater systems. (1) Epibiont-derived organic carbon is transported to the predators together with the host and forms a shortcut through the food web from dissolved organic carbon to higher predators. (2) Potentially pathogenic bacteria can attach to zooplankton and migrate with them, dispersing through great distances to areas that are considered pristine. The project follows a bottom-up approach from experimental assessments of the uptake of single cells attached to rotifers to the statistical inference on the effects of rotifer and bacterial communities. The questions are addressed by state-of-the-art methodologies, (tracer uptake, chemostat experiments, next generation sequencing and statistical models) by combining the expertise of a microbial ecologist (the experienced researcher, ER) and an evolutionary ecologist working on animals (the host). The study will be the first one to quantify the impact of epibionts on carbon transfer to higher trophic levels and the host-mediated distribution of bacterial genotypes in nature. The cross-disciplinary training of RAVE will considerably distinguish the ER from other microbial ecologist and prepare her for a further career in the field of microbe-zooplankton interactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FOSTERING EUROPEAN UNION - CARIBBEAN RESEARCH AND INNOVATION NETWORKS' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The EUCARINET project is a 4 years Coordination Action whose main goal is to strengthen bi-regional sustainable policy dialogue on S&T between EU Member States (MS), Associated States (AS) and in the Caribbean Region, the Caribbean ACP States, the overseas Departments and Collectivities, the Overseas Countries and Territories (OCTs). The project will work at policy, programme and institutional (research entities) level, thus contributing to a threefold objective: 1) create the conditions of the sustainable multi-stakeholders policy dialogue on S&T between the European Union, its member states, its associated states and the Caribbean Region, leading to a joint definition of S&T co-operation policies, 2) Foster interregional (UE-CARIBBEAN) and intraregional cooperation in leading to the identification and prioritisation of common research areas of mutual interest and benefit. 3)Stimulate and support the participation of the Caribbean research stakeholders in FP7, with a first emphasis on the “People Programme”. In order to do that, the consortium of thirteen members both from EU and the Caribbean will implement a 5 WP's workprogamme: management, dialogue platform establishment, priorites setting, instrumentsfor sutainable cooperation and dissemination/networking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models' under Horizon 2020.

assistant: **Concept**

Autism Spectrum Disorders (ASD) are a group of neurological conditions characterized by stereotypical or repetitive behaviours as well as impairments in social interaction and communication skills, often of genetic basis. ASD have been classified as neurodevelopmental disorders, implying irreversible defects in the maturation of neural circuits. We have shown that mutations in the Branched Chain Ketoacid Dehydrogenase Kinase (BCKDK) gene lead to a potentially preventable and reversible form of ASD (Novarino et al. Science 2012). The most direct consequence of BCKDK mutations is a hyper-metabolism of the branched chain amino acids (BCAAs), resulting in atypically low levels of serum and brain BCAAs. Recently, using whole exome sequencing we identified individuals with ASD carrying mutations in the gene SLC7A5, encoding for the transporter mediating BCAA flux across the blood brain barrier. This suggests that the BCAAs are critical for brain development and cognition and reinforces their link with ASD. The simple nature and availability of the BCAAs prompt raising the possibility that this group of amino acids may be employed to treat symptoms of other ASD. We aim at 1) elucidating the link between BCAAs, ASD, brain development and cognition; 2) exploring the possibility of employing the BCAAs to reverse symptoms caused by mutations of ASD-genes.The genetic analysis of ASD is untangling the etiological heterogeneity that may contribute to poor clinical trial outcome. However, recent studies, including our own (Novarino et al. Science 2014), show that genetic causes of neurological disorders converge along specific biological processes. Our third objective is to employ stem cell-derived human cerebral organoids to identify key molecular changes involved in the pathology of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Fgf receptor-2 signalling in mouse development'.

assistant: **Concept**

Research objectives and content  Members of the fibroblast growth factor (FGF) family are implicated as important cell to cell signalling molecule in animal development. The role of FGF signalling in human development has been further highlighted by the demonstration that mutations in FGF receptor-3 are the major cause of human dwarfism, and mutations in other FGF receptors cause several inherited skeletal dysplasias of children. As targeted deletions of FGF receptor-2 are lethal in the mouse at implantation, we plan to use a more delicate approach where only one of the two alternative FGFR-2 isoforms are mutated in the mouse germline. In addition, the approach will generate other lines of mice where the FGF receptor mutations are restricted to specific cell lineages. This will allow us to investigate the significance of FGF signalling in early mammalian development, organogenesis, and homeostatic mechanisms such as wound repair. Training content (objective, benefit and expected impact) This project will provide training in mouse developmental genetics and mammalian embryogenesis. The results should provide a better understanding of how FGFs affect lineage determination and tissue patterning and may have a direct impact on the understanding of some skeletal dysplasias. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ultra Hard Materials for Tribological Application' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

At present, there is a tremendous industrial need for materials with major engineering applications in these situations where tribology is important, exemplified by machining and metal forming (cutting/milling inserts, extrusion/drawing dies), bearings, gears, valve guides/tappets in engines and in valves, seals and bearings involving fluid and gas transport often under corrosive conditions. The majority of these applications are currently served by hard steels and WC based hard metals with or without surface coatings. New materials or improved existing materials, however, are needed. The materials of interest will have to combine high hardness, modulus and wear resistance coupled with relatively low density, resulting in low inertia under reciprocating stresses. The fundamental understanding of the relationship between composition, microstructure, processing route, wear behaviour and performance should be clarified in order to optimally use the engineered materials in tribological applications. The broad objectives of this basic research proposal are: i. To further develop and refine processing routes and microstructures of 3 novel types of TiB2 based materials, two ceramics and one cermet, which have potential applications as low density/high modulus wear and bearing components with emphasis on minimising fabrication costs, coupled with higher performance than existing components. Two grades of each material type will be developed. Target properties for these materials are: for the first class of ceramics, a toughness of up to 10 MPa m1/2 coupled with a hardness of up to 25 GPa at a density of 3.5 g/cm3. For the second class of ceramics, a toughness of up to 10 MPa m1/2 coupled with a hardness > 15 GPa at a density of 5.5 g/cm3. For the cermets, a toughness of up to 1