RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ocean incursion and melting near ice-sheet grounding lines via high-resolution large-eddy simulations' in the context of a Horizon Europe call.

assistant: **Objectives**

Ice shelf melting and retreat are accelerating in polar regions because the warm off-shore waters are gaining greater access to the base of ice shelves. Warm waters have the potential of reaching the grounding line and thereby melting it causing the retreat of the full ice shelf, resulting in elevated rates of ice discharge into polar seas and sea level rise. The interconnection between ocean conditions, warming, and ice melting in ice-shelf cavities is poorly understood due to the paucity of observations and turbulence-resolving simulations. This knowledge gap hinders future projections of ice changes and makes it impossible to predict if and when tipping points will be crossed within the 21st century, as their timing critically depends on the details of ice-ocean interactions. GLmelt aims to fill the critical knowledge gap pertaining to the relationship between ice melting rate and ocean conditions by running numerical simulations capable of resolving turbulence. They focus on near-grounding-line regions where ice sheet sensitivity to ice melting is greatest. GLmelt objectives are:1.Developing an open-source numerical model capable of resolving under-ice ocean dynamics near grounding lines2.Investigating melt rate distributions considering a range of ice-shelf cavity configurations found in nature3.Investigating how the characteristic melt rate distributions vary with problem parameters in quiescent ocean conditions4.Quantifying the effect of long-shore currents 5.Organizing a workshop reviewing state-of-the-art knowledge in dynamical processes controlling basal ice melting and guiding practices in choosing melting parameterizationsGLmelt will enable the candidate fellow to deliver high-impact research outcomes to the research community, environmental policymakers, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of SYNGAP1 isoforms in brain development' (SYNGAP-IsoDev) targeting Horizon Europe.

assistant: **Abstract**

Synaptic Ras GTPase activating protein (SynGAP) is crucial for neuronal communication and is highly concentrated in excitatory synapses. Mutations in the SYNGAP1 gene cause SYNGAP1-related intellectual disability (SRID), a neurodevelopmental disorder characterized by epilepsy, developmental delay, and autism. As there is no cure for SRID, this proposal will elucidate SYNGAP1 expression and function during development. In the adult brain, SynGAP regulates synaptic plasticity by interacting with other proteins to modulate synaptic strength. Recent studies suggest non-synaptic functions for SynGAP during neurodevelopment, regulating cell type specification in early cortical formation. This study will pioneer the investigation of SYNGAP1 isoform function and regulation across brain development.SYNGAP1 encodes for multiple N- and C-terminal isoforms with unique roles in synaptic function. Mouse models revealed that SynGAP-α1 affects synaptic plasticity, while SynGAP-β influences dendritic growth. Despite this, the regulation of the gene and its mRNA and isoform expression, especially during neurodevelopment, remains poorly understood. Preliminary analysis shows differential SYNGAP1 N-terminal isoform expression prenatally compared to adult brain. We hypothesize that (i) SYNGAP1 isoform expression is transcriptionally regulated in neurodevelopment with differential isoform usage between pre- and postnatal stages, and (ii) these isoforms have unique functions. We find that CRISPR activation (CRISPRa) upregulates Syngap1 in adult mouse hippocampus, offering a promising approach for modulating isoform expression. To test these hypotheses, we aim to employ cutting-edge techniques in mouse and human SRID models. Approaches include targeted long-read sequencing, intrahippocampal CR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Genome editing for spatiotemporal analysis of centriolar SATellite BIOgenesis and FUNction in cellular stress responses' (SATBIOFUN).

assistant: **Concept**

The centrosome is the major microtubule-organizing centre of a cell. It also serves as the base for the primary cilium, an antenna-like structure that allows cells to respond to external stimuli. Around the centrosome lie a number of electron dense cytoplasmic granules, termed centriolar satellites. These are involved in protein trafficking and are crucial for normal centrosome and cilium assembly and function. However, little is known about satellite composition, biogenesis or regulation. Mutations in a number of genes encoding satellite proteins cause ciliopathies, demonstrating their importance in the etiology of disease. Emerging data also shows that satellites contribute to the cellular stress response. The central scientific goal of this proposal is to systematically dissect, for the first time, the molecular mechanisms underpinning centriolar satellite biogenesis and function. Coupling genome-editing and cutting-edge imaging techniques we will perform morphometric quantitative analysis of satellite proteins to delineate their specific role in the cellular response to stress. This project encompasses an Outgoing Phase during which the Fellow will be trained in advanced, high-content, automated, and super-resolution microscopy, and computational analysis to study satellite biogenesis and function. Within this phase a secondment to the biotech sector will occur during which the Fellow will learn cutting-edge DNA manipulation methods. The Return Phase allows the transfer of this knowledge to Europe whilst the Fellow receives training in the analysis of stress responses. Alongside this the Fellow will follow a program of courses to acquire a range of complementary skills, including industry-related skills and teaching qualifications. Together, this will accomplish the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advanced Intra-Operative Navigation in Arthroscopy Surgery'.

assistant: **Objectives**

Perceive3D (P3D) is an ICT driven company specialized in computer vision technology that creates advanced image software solutions for assisting and guiding the surgeon during minimally invasive procedures. In this project, P3D will specialize its state-of-the-art in.nav software technology for arthroscopic procedures of the knee and hip, providing the first effective solution for Computer-Assisted Orthopedic Surgery (CAOS) in arthroscopy. The outcomes of the project will be two software applications (nav4ACL and nav4FAI) that will provide real-time intra-operative measurements to aid the surgeons throughout the procedures by providing measurements of the joint structure. Guiding information is provided in accordance to the literature to support the surgeon’s decision, leading to a system that will improve clinical outcome for patients and reduce healthcare costs. As part of the Horizon 2020 SMEInst-01 phase I project, P3D performed a feasibility study for the development of in.nav navigation software for two arthroscopic procedures: the Antero Cruciate Ligament (ACL) reconstruction in knee arthroscopy, and the removal of Femoroacetabular Impingement (FAI) in hip arthroscopy. A pressing need for assistive systems has been reported for the procedures for these frequent pathologies. This phase II project will leverage these results and translate the in.nav prototype into two commercially viable software products for ACL and FAI procedures. P3D will demonstrate the use and advantages of the in.nav navigation software through tests in post-mortem subjects and will prepare the applications for integration into existing surgical workflows and market deployment. P3D has already approached Key Opinion Leaders (KOL) in the targeted procedures (Knee and Hip) to endorse the in.nav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Advanced research centre for cultural heritage interdisciplinary projects'.

assistant: **Objectives**

Enhanced reflection of social and economic issues in the research of cultural heritage problems, increased intensity of co-operation among European countries, new network arrangements; lines for concerted or joint a special programmes for young researchers, economic and social stability of small regional units and for integration of cultural heritage message into development of appropriate (eco-)technologies; ARCCHIP Centre operating a virtual international information centre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An ethical framework for the risk-based regulation of biomedical research' to be submitted under Seventh Framework.

assistant: **Abstract**

Background: Biomedical research has important social and economic value. It helps to promote individual and population health, boosts competitiveness and innovative capacity, and thereby contributes to economic growth. Yet, biomedical research exposes study participants to risks. Research also poses risks to public health when the science is poor. The ethical acceptability of research therefore critically depends on protecting participants’ rights and safety, while promoting the scientific and social value of the research. Research regulations are designed to ensure that these requirements are met. -- Patient organizations, investigators, sponsors, and others are increasingly dissatisfied with the existing regulatory framework. Many call for a “risk-based” system of research oversight that matches various safeguards – including independent ethical review and safety monitoring and reporting – to the level of risk posed by the research (e.g., revision of the EU Clinical Trials Directive). However, it remains unclear what such a system should look like.Objectives: 1) To address the ethical questions raised by risk-based research regulations, including the stratification of research risks and the relation between risk, consent, and the scientific and social value of the research. 2) To develop an ethical framework for risk-based research regulations.Methods: Interdisciplinary study that combines conceptual and normative analysis, policy analysis, and expert consultation.Target audience: Policymakers, research regulators, research ethicists, and others interested in the ethics and regulation of risk.Impact: By calibrating safeguards and protections to the level of risk posed by a study, the envisioned framework will help to promote valuable research consistent with adequate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Embo biology teachers workshops: continuing education for european biology teachers ceebt' under Fifth Framework.

assistant: **Concept**

A series of workshops on the molecular life sciences is planned for secondary school teachers in the EU Member States and Israel. 12 teachers workshops in this initial project will be held at the European Molecular Biology Laboratory (EMBL) in Heidelberg (D), its outstations in Hamburg (D) and Hinton (UK), and at the Centro National de Biotechnologies, CSIC, Madrid (E), the Technical University, Copenhagen (DK), and the Belmont Laboratories, Jerusalem (IL) over two years: 6 at each location during Sprung-Summer 2003 and 6 during Spring-Summer 2004. Teachers from each of the regions of Europe and Israel will participate. The European Molecular Biology Organisation (EMBO) will be the co-ordinator, and together with the European Federation of Biotechnology (EFB), will manage the project as co-principal contractors in collaboration with the 6 locations. The latter will organise the workshops under sub-contract, building on the experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Photonics Solutions at Pilot Scale for Accelerated Medical Device Development' to be submitted under Horizon 2020.

assistant: **Abstract**

Photonics technologies have become a key enabler in the realization of modern medical devices with applications ranging from diagnostics to surgical tools and therapeutics. Characteristic nature of both photonics and application fields is high diversity. Consequently, the more widespread use of photonics technologies in scattered ecosystems presents major challenges for both end-user companies and manufacturers. In conjunction with highly regulated validation and production, the timespan from the concept phase to product launch takes years. Addressing these challenges, MedPhab will serve as Europe’s first Pilot Line dedicated to manufacturing, testing, validation and up-scaling of new photonics technologies for medical diagnostics enabling accelerated product launch with reduced R&D costs. MedPhab will bring the high-quality infrastructure and extensive know-how within easy reach of the SME’s and other European Industry. Globally unique feature of MedPhab is its operation in medical domain setting requirements to meet regulations. The competitive differentiation is the seamless operation between ISO13485 certified companies and RTOs when single-entry point can serve SMEs operating at different TRLs. Professional customer interface will be operated by staff with extensive experience in the field medical devices. The technology readiness and MedPhab operation process will be validated by: 1) Use Case Validation program, upscaling and demonstrating performance of 5 innovative medical diagnostics products; 2) Demo Case Open Calls program enabling early adoption of the technologies by external user, demonstrating the pilot line services and validating the open access business model.


**Keywords:** Medical diagnostics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Centre of Excellence in Artificial Intelligence for Digital Humanities' (AI4DH) targeting Horizon Europe.

assistant: **Abstract**

The Centre of Excellence (CoE) in Artificial Intelligence for Digital Humanities (AI4DH) Era Chair is an ambitious initiative in Slovenia designed to enhance this European regions capacity to integrate Artificial Intelligence (AI) into the research conducted at the University of Ljubljana in Digital Humanities (DH). This project seeks to establish the university as a leading institution in Europe for AI applications in DH through the creation of a CoE that combines top-level AI research with direct engagement and support for DH scholars. The CoE will foster research excellence and provide tailored training and services, thereby increasing the humanities' capacity to leverage the many exciting opportunities offered by AI. The CoE will attract projects and other funding, ensuring its sustainability, enhancing the university's research infrastructure, and reversing the regions brain drain by attracting researchers to Slovenia. The AI4DH centre will be created under the leadership of Professor Antoine Doucet, who is currently Professor in Computer Science at La Rochelle Universit, France. Prof. Doucet has an excellent track record, both as a researcher and innovator, with many accolades as a manager of research and interdisciplinary higher-education activities.


**Keywords:** artificial intelligence, digital humanities, linguistics, social sciences,  natural language processing, data science, large language models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Symmetry Investigations in Flavour Theories' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Flavour remains a deep puzzle in elementary particles. The Standard Model (SM) describes most data - but observations and theoretical reasons guarantee there is physics beyond.Why 3 generations in each family, and masses spanning over 10 orders of magnitude? Why is the mixing of quarks and leptons so different? Flavour puzzles go beyond the SM, with extensions like supersymmetry constrained to very specific flavour structures. These strongly imply underlying physics addressing flavour.Symmetries are extremely important in elementary particles. Unsurprisingly they are promising to understand flavour. Family symmetries relate generations, and can explain flavour in the SM and in extensions.Experimental effort is led by the LHC, recently discovering a particle likely to be the Higgs boson, searching for supersymmetry and probing flavour in LHCb. Increasingly precise neutrino experiments Daya Bay and RENO observed the 3rd mixing angle. Dedicated experiments probe rare processes such as neutrinoless beta decay or muon conversion.Cosmological observations test dark matter (likely to be an unobserved particle), the matter asymmetry of the Universe quantitatively requires a mechanism linked to new physics (such as leptogenesis) and Big Bang Nucleosynthesis is sensitive to SM modifications.In association with the experimental effort, theory is fundamental: to guide searches and to understand results.This proposal seeks the fundamental Theory of Flavour - possibly an ambitious supersymmetric unified theory with a family symmetry. It is fundamental to thrive on the abundance of data to guide theory in an integrated interdisciplinary way.Taking a broader view of flavour topics may lead to high impact breakthroughs from new approaches.Overall the project is expected to significantly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SCIENTIFIC UNDERSTANDING AND VISION-BASED TECHNOLOGICAL DEVELOPMENT FOR CONTINUOUS SIGN LANGUAGE RECOGNITION AND TRANSLATION'.

assistant: **Concept**

Deaf communities revolve around sign languages as they are their natural means of communication. Although deaf, hard of hearing and hearing signers can communicate without boundaries amongst themselves, there is a serious challenge for the deaf community in trying to integrate into educational, social and work environments, as the vast majority of Europeans do not have signing skills. The overall goal of SignSpeaker is to develop a new vision-based technology for translating continuous sign language to text, in order to improve the communication between deaf and hearing communities. To this end, at the beginning of the project a new scientific study will be carried out to increase the linguistic understanding of sign languages; this new knowledge about the nature of sign language structure from the perspective of machine recognition of continuous sign language is crucial for a further development of sign-language-to-text technologies. The breakthrough in the understanding of sign language will allow a subsequent breakthrough in the development a new vision-based technology for continuous sign language recognition and translation to text. The SignSpeaker system will track the dominant and non-dominant hand, as well as facial expressions and body posture, taking into account the signs performed before and after or, in other words, taking into account the context in which a sign has been realised; the new technology will be also signer and ambient-independent. SignSpeaker will be the first step to approach sign language recognition and translation to the levels already obtained in similar technologies like translating from text-to-speech and speech-to-text. But the impact of SignSpeaker's results is much broader than the unique application in sign languages, because the re