RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Designed nanostructured hybrid polymers: polymerisation catalysis and tecton assembly' to be submitted under Sixth Framework.

assistant: **Abstract**

Learning from nature, the major objective of the Nanohybrid project is to develop fundamental knowledge in order to be able to elaborate new melt processable nanophase-separated hybrid materials with controlled architecture, derived from low cost petrochem ical olefin feedstocks without sacrificing easy polymer melt processing. On the contrary to most current nanocomposites, where mainly physical bonding between nanofiller and matrix are obtained, the NANOHYBRID project will strive for combining chemical and physical bonding which would allow a real breakthrough in material's properties. The project will be focussed on : 1) Creation of new knowledge related to macromolecular architecture designs via transition metal catalysis which will open up access to nove l random and block copolymers (BCs) and polymer product compositions. 2) Understanding the phenomena of nanocompomers' and nanocomposites' formation either during in-situ polymerisation or during melt processing 3) Investigation of fundamental characterist ics of the organic-inorganic interphase region by multi-scale analysis. 4) Application-oriented property enhancement, thanks to nanostructured hybrid polyolefins. In the medium to long term, tecton and hybrid approaches to advanced nanostructured polymers via catalytic polymerisation combined with block copolymer self-assembly will offer unique benefits and opportunities for new applications and products. Targeted enhanced properties are: scratch resistance, modulus improvement without sacrificing stiffness , heat distortion temperature, flame retardancy, barrier properties (super hydrofobic/hydro philic, UV radiation, conductivity, antimicrobial, etc.). The industrial sectors concerned could be automotive, communication technology, MEMS, packaging, and texti le.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Synthesis of chiral and non racemic perfluoro cis-2,3-dialkyloxaziridines' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Perfluoro cis -2,3- dialkyloxaziridines showed high efficiency for several oxidation reactions. Their use afford good yield, high chemo-,site-, regio- and stereoselectivites . It would be very interesting to make available oxaziridine in optically active form, due to their specific reactivity and their belonging to a new class of unknown compounds. New methods for asymmetric synthesis of perfluoro oxaziridines will be studied, starting from azaalkenes and (e.g (+)-monopercamphoric acid) or different chiral peracid. Effect of the oxidizing agent on the chemical and optical yield will be established. The mechanism between substract and oxaziridines will be investigated, this research will use the kinetic resolution of oxaziridines. The optical purity of resolved oxaziridines will be determined; Normal methods in this case are inaccurate. Development of new method of resolution will be pursued, we have to use a double kinetic resolution with a known optical purity compound. Training content (objective, benefit and expected impact) This is a research project in a new field in organic chemistry: CHIRAL AND NON RACEMIC PERFLUORO cis-2,3- DIALKYLOXAZIRIDINES". I will obtain new knowledge in fluorochemistry and optical purity resolution and improve my former organic synthesis ability. No real links with industry but possibilities of technology transfer are possible. (Exxon, 3M, Dupont DeNemours) Links with industry / industrial relevance (22) "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mid-High Frequency Modelling of Vehicle Noise and Vibration' to be submitted under Seventh Framework.

assistant: **Abstract**

The control (and avoidance) of vehicle noise and vibration (NV) provides a crucial competitive advantage for car manufacturers due to the drive for lower noise pollution levels and enhanced driving comfort. NV issues can seriously detract from the reputation of a vehicle with a knock-on detrimental effect for the entire brand.As the automotive industry moves towards virtual prototyping, the simulation and modelling of vehicle NV is becoming increasingly important. Providing accurate numerical predictions in this area is an extremely challenging task. A detailed analysis of the structural vibrations on very fine scales is required, and small parameter changes can lead to large shifts in the frequency response function for a given vehicle. The wide range of materials and intricate couplings between different components provide enormous challenges for the NV simulation of a full vehicle, especially in the range of frequencies above 500Hz. Robust and efficient NV modelling techniques are, however, urgently needed by vehicle manufacturers for cutting costs by removing the need to develop expensive physical prototypes.The range of existing techniques addressing NV issues as part of the Computer Aided Engineering (CAE) toolkit is not adequate. The methods are not robust for frequencies over 500Hz and do not naturally fit into the simulation environment of CAE, where structural data are provided via mesh specifications. Only recently have these problems been overcome through new solution techniques developed and tested by the academic members of this project. Together with two specialized SMEs and the car manufacturer Jaguar Land Rover, this interdisciplinary and inter-sectoral consortium will develop the first black-box and mesh based tool for the vibro-acoustic analysis of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Design study and experimental evaluation of an integrated solar facade' (1994-1998) under Fourth Framework.

assistant: **Objectives**

There are key advantages in cost and performance to be gained by combining photovoltaic and solar thermal functions into the south facing facade of a building. This research proposal seeks to build on the experience gained with the Mataro library project (supported by the JOULE programme). In particular, the innovative introduction of dedicated solar air heaters into part of the facade and the use of forced ventilation will be explored, in view of the requirement for higher air temperatures. Ventilation can be directly powered from the photovoltaic array, thereby minimising wiring and providing a robust self-contained system. The way in which the facade can be utilised for building heating and cooling will be explored in the context of an integrated building design incorporating underground thermal storage. By using a partially transparent facade, natural daylighting can be provided through the south face of the building, without associated overheating. It is intended that this research project will result in design guidelines for such buildings, and in particular a detailed design for an integrated solar building which would later be constructed as part of the planned new Engineering complex at Loughborough University, using the technology developed. It is well known that photovoltaic modules perform more efficiently at low temperatures. For crystalline silicon modules, the efficiency falls by around 4 to 5 for each 10 degree C increase in temperature. For this reason some researchers have started to look at the cooling of PV facades, generally by allowing natural convection of air behind the solar panels. This has led to consideration of whether the heat generated could be usefully used to pre-heat the air supply to the building. Among the first demonstrations of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Improvement of Microbiological Control in closed water systems for the paper and board industry'.

assistant: **Innovation**

The water consumption of the paper and board industry, compared to other industries, is of major importance. The current state-of-the-art already avoids about 90% of fresh water consumption by internal recirculation. Further reduction by extended system closure leads to considerable loading of the process water by dissolved fixed and volatile solids which favour the growth of microorganisms. To inhibit or destroy the microorganisms and to prevent slime formation, metal corrosion and bad odours in paper mills biocides are being applied. These are toxic substances that usually impair metabolic activities and by that can impose threats to man's health and to the environment. The planned project aims to control microbial activity in closed water systems without application of hazardous substances. The strategy, however, is not to search nonhazardous compounds and replace currently available biocides. The key to environmentally friendly microbial control is the knowledge of microbial behaviour and interaction in the process water.The first step is the development of reliable and specific methodologies which allow to measure microbial  activity and to predict problems with paper machine operation and product quality caused by those.  Commercially available methods to check water systems will be evaluated to assess their potential of  differentiating between viable and inhibited cells, slime forming and non slime forming bacteria. Beyond  conventional technologies a new approach is made to describe microbial activity directly related to paper  machine operation. Methods of chemical, biochemical and microbiological analysis are being combined to  differentiate between microorganisms capable of deranging paper machine operation or product quality and  microorganisms which influe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Future Proofing Health- and Care Systems Safeguarding Health Care Workers in Hospital Settings' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

BACKGROUND: Healthcare professionals working in hospitals and those in training to embark on hospital careers experience high levels of stress, especially in the surgical pathways. While interventions to improve wellbeing and resilience exist, not much is known about the right (combination of) intervention(s) for this specific setting. AIM: KEEPCARING aims to (re-)build wellbeing and resilience of healthcare workforce in EU hospitals by co-creating a multi-faceted non-digital, digital and AI-supported solution package to prevent burnout among (aspirant) healthcare professionals on the individual, team, and organisational level.APPROACH: Our multi-sector and interdisciplinary consortium will (1) study stress and stressors experienced by (aspiring) health care providers in their specific setting, (2) evaluate digital and non-digital solutions to reduce stress at an individual and team level, (3) study job crafting among (aspiring) health professionals as a way to reduce stress, and (4) finally, develop a change management platform that, using explainable AI, helps hospital managers as well as surgical caregivers to choose the solutions that match their context. All solutions as well as the portal will be developed in co-creation with end users, including 2 professional associations in our consortium. In addition, legal and ethical expertise is provided across Partners and in Advisory Board to ensure privacy and ethical guidance in this sensitive context. IMPACT: KEEPCARING will provide solutions to improve wellbeing among health care professionals and students, thereby reducing burnout and improving the number of health care students entering the workplace. Our organisational solutions will empower individuals and employers to understand and act on stressful situations in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Epigenetic challenges in centromere inheritance during the cell cycle' (ECCENTRIC).

assistant: **Concept**

Studies concerning the mechanism of DNA replication have advanced our understanding of genetic transmission through multiple cell cycles. Recent work has shed light on possible means to ensure the stable transmission of information beyond just DNA and the concept of epigenetic inheritance has emerged. Considering chromatin-based information, key candidates have arisen as epigenetic marks including DNA and histone modifications, histone variants, non-histone chromatin proteins, nuclear RNA as well as higher-order chromatin organization. Thus, understanding the dynamics and stability of these marks following disruptive events during replication and repair and throughout the cell cycle becomes of critical importance for the maintenance of any given chromatin state. To approach these issues, we propose to study the maintenance of heterochromatin at centromeres, key chromosomal regions for the proper chromosome segregation. Our current goal is to access to the sophisticated mechanisms that have evolved in order to facilitate inheritance of epigenetic marks not only at the replication fork, but also at other stages of the cell cycle, during repair and development. Beyond inheritance of DNA methylation, understanding how inheritance of histone variants and their modifications can be controlled either coupled or not coupled to DNA replication will be a major focus of this project. Our studies will build on the expertise and tools developed over the years in a strategy that integrates molecular, cellular, and biochemical approaches. This will be combined with the use of new technologies to monitor cell cycle (Fucci), protein dynamics (SNAP-Tagging) together with single molecule analysis involving DNA and chromatin combing. We wish to define a possible framework for an understand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lysosomes as targets for cancer therapy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Knowing that the lysosomes contain a powerful cocktail of hydrolases capable of digesting cells and entire tissues, it is obvious that the maintenance of lysosomal membrane integrity is of utmost importance for all cells, and especially for cancer cells with dramatically increased lysosomal activity. Yet, the mechanisms that regulate lysosomal membrane stability have remained obscure, largely due to the lack of methods sensitive enough to detect partial lysosomal leakage and suitable for screening purposes. We have finally succeeded in developing such a method, which allows me to propose here a project whose major aim is to reveal how cells maintain the integrity of lysosomal membranes. Based on our emerging data that firmly connect heat shock protein 70 and sphingolipid metabolism to lysosomal membrane stability, we will devote a large part of the project to the molecular details of these connections and to the characterization of the effects of new and already approved (cationic amphiphilic drugs) sphingolipid-regulating drugs on lysosomal membrane stability and cell survival. Additionally, we will screen selected siRNA libraries to identify signaling networks and lysosome-associated proteins essential for lysosomal membrane integrity, and small molecule libraries to identify compounds that induce lysosomal cell death. The next step is to identify lysosome-stabilizing mechanisms that are especially important for cancer cell survival. And the ultimate goal is to validate corresponding drug targets and drugs (old and new) for the induction of lysosomal cell death in therapy resistant cancers. As a “by-product” we expect to identify putative drug targets for the treatment of degenerative diseases and lipid storage disorders, where the stabilization of the lysosomal membr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'My Active and Healthy Aging' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

BackgroundWe propose a holistic view of interrelated frailties: cognitive decline, physical frailty, depression and anxiety, social isolation and poor sleep quality, which are a major burden to older adults and social and health care systems. Early detection and intervention are crucial in sustaining active and healthy ageing (AHA) and slowing or reversing further decline.Aims and RelevanceThe main aim of my-AHA is to reduce frailty risk by improving physical activity and cognitive function, psychological state, social resources, nutrition, sleep and overall well-being. It will empower older citizens to better manage their own health, resulting in healthcare cost savings. my-AHA will use state-of-the-art analytical concepts to provide new ways of health monitoring and disease prevention through individualized profiling and personalized recommendations, feedback and support.ApproachAn ICT-based platform will detect defined risks in the frailty domains early and accurately via non-stigmatising embedded sensors and data readily available in the daily living environment of older adults. When risk is detected, my-AHA will provide targeted ICT-based interventions with a scientific evidence base of efficacy, including vetted offerings from established providers of medical and AHA support. These interventions will follow an integrated approach to motivate users to participate in exercise, cognitively stimulating games and social networking to achieve long-term behavioural change, sustained by continued end user engagement with my-AHA.Scale and SustainabilityThe proposed platform provides numerous incentives to engage diverse stakeholders, constituting a sustainable ecosystem with empowered end users and reliable standardised interfaces for solutions providers, which will be rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Environmental control with the aid of sensor technologies for GAS sensing' (1994-1998).

assistant: **Innovation**

Foreseen ResultsAVANGARD will develop a substrate for the common use by all partners. The substrate will be designed in order to be produced using the extended microelectronics technological lines existing in AVANGARD and will be available to all partners starting from the second year. In the same time AVANGARD will test the possibilities of gas sensors preparation by thin-film techniques. The final result of the project will consist in novel gas sensors for the monitoring of indoor and ambient air quality with enhanced stability and selectivity. There will be different constructive solutions from the point of view of the substrate and the technology of obtaining the sensing layer.The objective of the project consists in the finding of new methods for the monitoring of indoor and ambient air quality by using novel types of gas sensors. The project aims to combine the knowledge of partners from EU and CCE/NIS countries in a synergetic research during which a double transfer will take place. The EU countries will transfer modern sensor testing equipment - one set up for routine and response time measurements and one set up for long term measurements - and knowledge about sensor quality requirements, in line with European environmental policy. They also will train young doctoral students of CCE/NIS partners. The CCE/NIS countries will transfer their extensive knowledge about sensitive materials properties and technological methods for obtaining such materials.IPC will ensure the coordination of the project. The gas stations will be constructed in IPC by doctoral students from CCE/NIS partners, under IPC coordination. IPC will train these students in using the gas stations and will transfer all the needed software. IPC will coordinate the change of information between partn