RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Studies in gaussian and non-gaussian analysis' (1994-1998).

assistant: **Concept**

the study of Non-Gaussian analysis in measure space is an old problem for which we expected to make progress using the methods of appell polynomials and infinite dimensional holomorphy see (3). The relevant aspect in this method is the extension of Gaussian case supplied with new technics. Self interaction local times of Brownian motion have been under study in the stochastic analysis literature for no less than forty years. For their intrinsic mathematical interest, but also in view of their applications in fields such as polymer physics and quantum field theory, see refs. In (1). Their increasingly singular nature as the spatial dimension increases poses increasingly difficult problems and suggests connections with renormalization methods of quantum field theory, but also with martingale methods as demonstrated in (2). Recently a considerable clarification of the singularity structure was obtained by the use of the chaos expansion for generalized white noise functionals (1). The present project aims at a strengthening of the missing link" between the methods of white noise analysis and those of martingale theory. We expect further clarification and progress for the renormalization theory of intersection local times in higher dimensions. With applications in quantum field theory and polymer physics, among others. Refere %lnces (1) DE FARIA, M., HIDA, T., WATANABE, H., INTERSECTION WHITE NOISE FUNCTIONALS. BIBOS (1994). (2) YOR, M., RENORMALISATION ET CONVERGENCE EN LOI POUR LES TEMPS LOCAUX D'INTERSECTION DU MOUVEMENT BROWNIEN DANS R3. SEMINAIRE DE PROBABILITE, 1993/94, LNM 1123 (1985), 35C-365. SPRINGER, BERLIN. (3) KONDRATIEV, Yu.G., STREIT, L.,-WESTERKAMP, W. AND YAN, J.-A., GENERALIZED FUNCTIONS IN INFINITE DIMENSIONAL ANALYSIS. SUBMISSION TO HIROSHIMA MATHEMATICAL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Brain dynamics and patterns of activity signature of inner speech during recall and conceptual emergence in bilinguals' in the context of a Seventh Framework call.

assistant: **Objectives**

Frege, in 1882, puts forward a philosophical account of language as symbols permitting the emergence of conceptual knowledge from individual memories. Since then, the influence of language on the episodic memory system and on the emergence of conceptual knowledge stays an undisclosed thesis. Life experiences are transformed into episodic memory via the hippocampus, the hippocampus in interplay with the ventromedial prefrontal cortex would then elicit the emergence of conceptual knowledge.In this project the hypothesized interdependency of the long term memory network on language processes will be experimentally assessed thanks to language manipulation in fluent bilinguals. It will focus on language specific processes in interplay with the hippocampo-ventro-Medial-Prefrontal Cortex patterns of activity and dynamics. Thus, the project will include two main enterprises: first, the neuroimaging and neurophysiological investigation of the influence of the used language on inner speech during life experience recall. Second, the neuroimaging and neurophysiological  investigation of the influence of the used language on the emergence of conceptual knowledge active in the network.The methodological objective of this project is thus to develop an integrated view of the human brain in play in the language-memory interdependency, using fMRI brain responses patterns, and assessing potential contribution of theta rhythms synchrony via the use of MEG.Application side, this project will give the first step in understanding the role of inner speech in long term memory, and the emergence of conceptual knowledge in the network. Applicability side, it will promote an adapted view on the self memory processes of bilinguals essential for clinical practices of psychopathology; moreover, the u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Lifelong UNiversal lAnguage Representation'.

assistant: **Objectives**

Why is machine translation between English and Portuguese significantly better than machine translation between Dutch and Spanish? Why do speech recognizers work better in German than Finnish? The main problem is the insufficient amount of labelled data for training in both cases. Although the world is multimodal and highly multilingual, speech and language technology is not keeping up with the demand in all languages. We need better learning methods that exploit the advancements of a few modalities and languages for the benefit of others. This proposal addresses the low-resources problem and the expensive approach to multilingual machine translation since systems for all translation pairs are required.LUNAR proposes to jointly learn a multilingual and multimodal model that builds upon a lifelong universal language representation. This model will compensate for the lack of supervised data and significantly increase the system capacity of generalization from training data given the unconventional variety of employed resources. This model will reduce the number of required translation systems from quadratic to linear as well as allowing for an incremental adaptation of new languages and data.The high-risk/high-gain relies on automatically training a universal language representation by specifically designed deep learning algorithms. LUNAR will employ an encoder-decoder architecture. The encoder represents an abstraction of the input by reducing its dimensionality,which will become the proposed universal language representation; from this abstraction, the decoder generates the output. The encoder-decoder internal architecture will be designed for learning the universal language representation,which will be appropriately integrated as an objective of the architecture.LUNAR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The HepaRG-Bio-Artificial Liver: Feasibility of commercialization and expansion of business plan' (BALXPAND).

assistant: **Innovation**

End-stage liver disease patients suffer from a dramatic loss of functional liver tissue, which leads to 50-80% mortality. Liver transplantation is the only effective therapy. However, this life supporting therapy is limited by the shortage of donor livers. As a consequence many patients die while on the transplantation waiting list. The SME Hep-Art has developed a bioartificial liver, the HepaRG-AMC-BAL, that has already shown to increase the survival time in animals with severe liver failure. The HepaRG-AMC-BAL is based on a bioreactor with the human liver cell line HepaRG, which is temporarily connected to the patient's circulation, leading to stabilization and possible recovery of the patient. The system is unique in its functionality and safety. In the BALXPAND project we aim to substantiate the economic perspective of the HepaRG-AMC-BAL. We develop a feasibility plan, including new data obtained in the BALXPAND project: a realistic estimation of production costs, based on a number of pilot runs for cell expansion, a list of large medical device companies for partnering and a list of interested Contract Manufacturing Organisations for GMP-compliant production of HepaRG-AMC-BALs. The resulting updated business plan will be a prerequisite for attracting future corporate partners for phase III trials and commercialisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EuroPanel user network' (EPUNET) targeting Fifth Framework.

assistant: **Abstract**

The EuroPanel is a hugely important source of data. Its potential value is not being realised. The consortium partners - already well used to working with each other - will provide services and facilities to all users. Our expertise will be made available to new users, to encourage much wider use of the data. Technical links between analysts will increase efficiency by reducing duplication of effort. The network will help researchers to find out about each other's research findings, and so stimulate growth in the quality as well as the quantity of outputs. It will contribute to the dissemination of ECHP-based research to policy makers at EU and national levels. While the network will develop the research infrastructure, the substantive research results likely to emerge across the ERA will also contribute conclusions highly relevant to 'societal and individual well-being'.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Assessment of the selected pops(pcbs,pcdds/ps,pocps)in the atmosphere and water ecosystems from the wastematerials generated by warfare in area of former yugosl' under Fifth Framework.

assistant: **Concept**

A great part of the former Yugoslavia has recently been encompassed by warfare. The caustic region warrants particular attention because of its exceptional ecological vulnerability to technological and hazardous wastes. Research on the environmental impact of warfare has shown that many sorts of highly stable organic contaminants have entered the environment because the whole range of the various materials used in enterprises, infrastructures and households produce dangerous economic, highly stable organic substances as a result of the various types of devastation that occur during warfare, especially burning. For this reason, it is necessary to investigate the levels and fate of Pops in those areas of the former Yugoslavia, which were affected by the recent war, especially the places where electrical transformer stations were destroyed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Metabolic crosstalk in the regulation of inflammation' (Metabinnate), addressing dissemination and exploitation.

assistant: **Impact**

The study of the molecular basis to the immune response has for decades concerned receptors and the signalling pathways they activate which lead to immune cell activation.  Recently metabolic changes have also been shown to couple to immune effector responses. A shift in appreciation of the role of metabolites beyond energy metabolism and biosynthetic processes has emerged.  We have been examining the role of three metabolites in macrophages. We have evidence that two of these, malonyl-CoA and 2-hydroxyglutarate (2-HG) are pro-inflammatory, whilst the third, itaconate, has profound anti-inflammatory effects. In many ways, they mirror cytokines, with malonyl-CoA and 2-HG being akin to pro-inflammatory cytokines, whilst itaconate resembles anti-inflammatory cytokines. The specificity and breadth of the role of these metabolites in macrophages will be mapped in this proposal. For malonyl-CoA we have evidence that it regulates GAPDH, IRG1/CAD (which synthesises itaconate) and the key cytokine IL-1beta. For 2-HG, we will examine the production and actions of its 2 enantiomers, D-2-HG and L-2-HG, focusing on their effect on HIF1alpha and epigenetic regulation. For itaconate we have evidence for a role in Type I interferon modulation, antigen presentation, inflammasome regulation and GAPDH and LDHA (which can produce 2-HG) activities. We also have evidence that OXGR1 is the receptor for itaconate. All of these aspects will be explored in detail. Critically we will also determine the relationship between these metabolites since we have evidence for cross-talk. Their dynamic regulation is likely to be a key aspect of how metabolic reprogramming controls macrophage function. Our studies point to a major shift in our understanding of how intracellular metabolic changes lead to inf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Directed Evolution of Enzymes that Modify Histone Tails' (DIREVME) targeting Sixth Framework.

assistant: **Abstract**

The modification of chromatin structure (e.g. by acetylation or methylation of the histone tails) plays a central role in transcriptional regulation, constituting an epigenetic code. Currently the dissection of the roles of individual modified histone residues is limited by low activity and/or specificities of isolated/recombinant histone modifying enzymes. We propose to combine directed evolution with biochemical and in vivo assays to understand the functional consequences of modifying specific histone residues. Natural histone-modifying enzymes will be used as starting points to evolve enzymes with have enhanced activities and altered specificities to probe biological function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enabling grids For E-science' in the context of a Sixth Framework call.

assistant: **Objectives**

EGEE (Enabling Grids for E-Science in Europe) aims to integrate current national, regional and thematic computing and data Grids to create a European Grid-empowered infrastructure for the support of the European Research Area, exploiting unique expertise generated by previous EU projects (DataGrid, Crossgrid, DataTAG, etc) and national Grid initiatives (UK e-Science, INFN Grid, Nordugrid, US Trillium, etc). The EGEE consortium involves 70 leading institutions in 27 countries, federated in regional Grids, with a combined capacity of over 20000 CPUs, the largest international Grid infrastructure ever assembled.The EGEE vision is to provide distributed European research communities with a common market of computing, offering round-the-clock access to major computing resources, independent of geographic location, building on the EU Research Network Geant and NRNs. EGEE will support common Grid computing needs, integrate the computing infrastructures of these communities and agree on common access policies. The resulting infrastructure will surpass the capabilities of localised clusters and individual supercomputing centres, providing a unique tool for collaborative computer and data intensive e-Science. EGEE will work to provide interoperability with other major Grid initiatives such as the US NSF Cyber infrastructure, establishing a worldwide Grid infrastructure.EGEE is a two-year project in a four-year programme. Major implementation milestones after two years will provide the basis for assessing subsequent objectives and funding needs. Two pilot applications areas have been selected to guide the implementation and certify the performance of EGEE: the Particle Physics LHC Grid (LCG), where the computing model is based exclusively on a Grid infrastructure to store and anal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of Density Functional Theory methods for Organic Metal Interaction' (DEDOM) under Seventh Framework.

assistant: **Objectives**

First principles Density-Functional Theory (DFT) methods have been widely applied for computing electronic and optical properties of different systems. Recently theoretical modeling of metal-organic interfaces received a much attention due to their importance in different nanoscience fields. However, common (i.e. local and semi-local) approximations to the exchange-correlation (XC) functional of DFT show several shortcomings in describing metal-organic energy-levels alignment and thus charge-transfer. Aim of the DEDOM (DEvelopment of Density functional theory methods for Organic Metal interaction) project is to elaborate new theoretical methods beyond the current state-of-the-art for the description of the electronic and optical properties of organic molecules linked or deposited on metal surfaces or metal nanoparticles. This task includes: i) the development of new and efficient XC functionals, based on optimized effective potential (OEP) and including exact-exchange and correlation from many-body theory, to obtain an accurate description of charge-transfer between organic molecules and metal surfaces; ii) the investigation of optical properties, including light-emission, of organic molecules on metal surfaces using Time-Dependent DFT; iii) the description of metals using Green’s functions and multi-scale approaches to investigate metal-induced modification of the optical properties of organic molecules, including fluorescence quenching or enhancement due to the coupling of electronic excitations to plasmons. The DEDOM project is theoretically and technically extremely challenging due to the use of unconventional orbital-dependent XC-functionals and it requires a strong interdisciplinary effort, joining solid-state physics, theoretical chemistry, electromagnetic engine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The European Library: Modular Extensions for Mediating Online Resources' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

A Specific Support Action under Activity 2.3.6.1 of FP6-2004-IST-3. Die Deutsche Bibliothek (National Library of Germany) coordinates this proposal in which the national libraries of all the new member states of the EU are participants. Other partners will be the British Library, the National Library of the Netherlands, the Swiss National Library and CENL  (Conference of European National Librarians). Indicative budget is EUR 1,4 million over 24 months.   This will be the first serious attempt to develop the research agenda for the knowledge society in the 10 new member states (NMS). Objective of the SSA is to increase the potential of the national libraries and related national networks to promote involvement of knowledge society actors in IST activities in FP6 and FP7 by ensuring better access to essential European information resources. Specifically, the project will extend the networking services developed by TEL (The European Library) to the 10 NMS, investigate the state of readiness of their knowledge society actors to participate in IST projects and activities, raise awareness and establish potential partnerships through seminars, meetings and exchanges and provide strong multilingual web support for easy access to networked resources and for local dissemination. The impact of the project will be that TEL services will be available in all 10 national libraries with an interface in the local language, and that NMS participation in future calls for the cultural heritage and learning sectors will increase to 40%. It is also expected that these developments will assist NMS participation in many other areas of EU-funded research.