RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Taking Care of Disabled Children: the Centre International de l’Enfance and Transnational Network, France-North Atlantic-Africa (1959-1989)'.

assistant: **Objectives**

By exploring the intersection between disability and childhood issues from a diachronic perspective, this project aims to demonstrate how disability gradually became, between the 1960s and 1980s, a key global issue that must be taken into account in any health and advocacy perspective targeting children. In order to respond to this general objective and thus fill a historical silence, the project studies the Centre international de l'enfance - CIE’s consideration of the needs of children with disabilities by identifying its role and measuring its influence within transnational networks. Created in 1949 by the French paediatrician Robert Debré, the CIE emerged as a major player in the transnational space of advocating for children, playing a complementary role to UNICEF.This project addresses important research gaps by studying the little-known and essential contribution of the Centre international de l'enfance to the development of the North Atlantic modern approach to the rehabilitation of people with disabilities. It fills major gaps in the historiography of children with disabilities in Africa and on the role and exchange of knowledge between CIE experts and local professionals in a de/postcolonial perspective. Through its interdisciplinary research focus and theoretical framework, this project makes an unprecedented contribution to a field of multidisciplinary studies that is still largely unexplored and in full emergence: Francophone studies on disability. Moreover, it aims to document the past of disabled children who have remained largely forgotten and invisible. Revealing the past of disabled children, this research addresses crucial and current questions on care, health issues, social policies for vulnerable populations. Finally, this pioneering project will di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The influence of Her2 status on mammary stem/progenitor cells' to be submitted under Seventh Framework.

assistant: **Abstract**

c-ERBB2/HER2 is a gene that is found overexpressed in ~25% of mammary tumours, and defines the molecular signature of one of the breast cancer subtypes: the HER2-positive tumour subtype. However, the role of the c-ErbB2 tyrosine kinase and the stem cell of origin of HER2-positive breast cancers are poorly understood. Our project aims to study the relationship between c-ErbB2 function and normal and tumour stem cells, as well as on the origin and development of HER2-positive tumours. First, we will study the effects of overexpressing c-ErbB2, or of knocking its expression down, on in vivo mouse mammary epithelial biology. Lentiviral transduction of primary mouse mammary epithelial cells combined with cleared fat pad transplantation and flow cytometric analysis of the resulting outgrowths will be used to study the role of the protein in the normal gland. Second, tumour cells will be isolated from mouse c-ErbB2/neu tumour models and limited dilution transplant assays of cell subpopulations will be used to identify tumour stem cells. Last, a Stop-Flox-Neu mouse model will be combined with transgenic mice carrying the Cre recombinase under different cell-type specific promoters to ask whether activity of c-ErbB2/neu in different subpopulations results in different tumour types with greater or lesser resemblance to human HER2-positive tumours. Identifying the origin of HER2 tumours may be critical for understanding resistance to HER2-targeted therapies as tumours of differing cellular origin may have distinct mechanisms of resistance. The knowledge of the relationships and interactions between HER2 and mammary stem/progenitor cells will be a key aspect of understanding both the role of HER2 in the normal breast and how its over-expression drives breast cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mire Ecosystem Transition Area Flux' (METAflux), addressing dissemination and exploitation.

assistant: **Impact**

Peatlands or mires contain about one third of this global terrestrial carbon pool which are located on between 3 and 6% of the global land area. In the boreal and sub-arctic areas permafrost covers about 18,782 x 103 km2 and peatlands or mires cover about 19% of this area. Observed mean annual air temperatures in these regions have increased by 2-3oC since the 1950s. Thawing permafrost leads to changes in the form and function of northern peatlands and is characterised by the transition of dry palsa mires to wetter peatland pits, depressions and pools. This project aims to use advance geospatial techniques (GIS, remote sensing and environmental modelling) to produce robust models that examine the impact of transition areas on the carbon balance of northern mire ecosystems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sounds of Rock Art. Archaeoacoustics and post-palaeolithic Schematic art in the Western Mediterranean'.

assistant: **Innovation**

The proposed research project will contribute to enhance and improve the study of the archaeoacoustics of post-paleolithic rock art, a line of research still in its infancy in Europe. In the human and social sciences, research on intangible heritage is on the rise, and archaeology has much to contribute. The project will focus on the relevance of acoustics as a factor for the production, location and active use of rock art sites and landscapes. It will do this by investigating  resonance, reverberation, echoes and soundscapes of a sample of six areas with Schematic rock art shelters dating from Neolithic to Early Bronze Age in the Western Mediterranean located in Italy (Gargano and Abruzzo), France (Var and Vaucluse) and Spain (Montblanc and Cieza). Schematic rock art is the only rock art tradition that is common in the whole of the Western Mediterranean. This style is characterised by the stylization and abstraction of representations, that are turned into mere outlines without losing the minimal identifying features. The aim of the project is to provide a level of objectivity, precision and accuracy in acoustic measurements and to develop a comparative study of the sensorial experiences sought by prehistoric communities. The objectives are: 1/ to explore whether the selection of schematic rock art sites to be decorated was related to the sonority of the place, in particular on the basis of their potential for enhancing resonance and reverberation and for producing echoes; 2/ to assess in each location what type of sound produces better effects, whether sounds made by percussive, wind instruments or by vocal music; 3/ to verify whether reverberation and echoes are associated with the presence or absence of particular motifs; 4/ to infer commonalities in the cultural co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Democracy without Majorities:  Political Representation under Minority Rule' to be submitted under Horizon 2020.

assistant: **Abstract**

Minority rule is a frequent phenomenon in many parliamentary democracies. In minority governments, political parties in cabinet neither enjoy majority support in the electorate nor in parliament. Minority rule has become more prevalent in a time when party systems in democracies are experiencing drastic changes. Citizens’ voting behavior has become more volatile, new challenger parties – including populist radical right parties – have permanently entered the political landscape, and parliaments have become more fractionalized. The implications of the increasing phenomenon of minority rule for the functioning of democracy and political representation are possibly far-reaching. Unfortunately, existing theoretical and empirical approaches are insufficient to understand the consequences of minority rule for party systems, governmental behavior, and citizens’ responses. MINORITYRULE’s objective is therefore to provide a broad and systematic comparative analysis of the implications of minority rule for political representation. The project investigates how minority rule affects the intensity of political polarization between political parties during parliamentary debates and election campaigns, how it constrains the responsiveness of governments to public opinion at the national and European level, and how citizens evaluate the legitimacy of minority rule. MINORITYRULE will accomplish these tasks on the basis of an unprecedented comparative data collection using novel multilingual text-as-data approaches and cross-national survey experiments. Ultimately, the project will lead to a new theory of political representation under minority rule. In light of changing party systems, MINORITYRULE will generate new insights about the nature of political representation in which governme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ice-sheet thickness reconstruction with uncertainty quantification' (IceSTRUQ), addressing dissemination and exploitation.

assistant: **Impact**

The Antarctic and Greenland ice sheets are fundamental to the Earth's climate system and the main contributors to sea-level rise. The overall ice-thickness distribution of an ice sheet is computed from sparse ice-thickness measurements using reconstruction methods. This data sparsity results in a marked uncertainty of the ice-thickness reconstructions, which is never taken into account in a mathematically rigorous manner. This implies large deviations between different ice-thickness reconstructions, delivering inconsistent estimates of sea-level rise rates.To remedy this, we propose formulating the ice-thickness reconstruction as a Bayesian inverse problem that combines data and mathematical models for ice-sheet dynamics. The solution of this inverse problem is a probability distribution for the ice-thickness, resulting in a rigorous quantification of uncertainty. However, conventional numerical methods either break down or become impractically slow when solving this problem. To circumvent this, we propose the design of a Monte-Carlo Markov-Chain (MCMC) method that combines ideas from multi-fidelity and the stochastic Newton MCMC methods. These are two sophisticated mathematical techniques that have achieved extraordinary reductions in computational time, allowing for previously unfeasible computations.We will apply our method to reconstruct the ice-thickness of the Antarctic Peninsula Ice sheet (APIS). This important Antarctic region has a complex geometry that has defied existing ice-thickness reconstruction methods. Our Bayesian inversion approach has the potential of reconciling dissimilar estimates of ice-discharge by quantifying confidence intervals via uncertainty.This highly interdisciplinary project will develop the applicant's mathematical and glaciological kn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'COMmunication and Assessment With Adaptive Realtime Environments' to be submitted under Horizon 2020.

assistant: **Abstract**

Imagine being able to hear, feel, and think – but not see or move. You cannot communicate in any way, but can hear doctors and family members saying that you are comatose and cannot understand or make decisions. Recent work has shown that this nightmarish situation is a reality for tens of thousands of people worldwide, who have been diagnosed as comatose but may in fact have some ability to understand. More recent work has shown that brain-computer interface (BCI) systems can help with re-assessment of these patients, and can even provide communication. Our Feasibility Assessment in ComaWare Phase I, and other very recent developments, have strongly supported our plan to provide new technology to help these patients. In addition to providing assessment and communication, our new mindBEAGLE prototype will also be able to provide prediction and rehabilitation. This is a highly disruptive technology that will create a new market and buyer group: patients who have been (mis)- diagnosed as unable to communicate. These persons, and their physicians and families, will be very highly motivated to convey their basic needs and desires, and seek rehabilitation to regain some cognitive and motor function. In addition to creating a new mindBEAGLE-Pro system specialized for severely disabled persons without vision, we will also develop, pilot-test, and launch a novel business focused on providing support for patients, their carers and clinicians. This evaluation will support our Commercialization Plan, along with user, market and IP research, targeted surveys of end users, business experts, researchers and other groups, Workshop Tours, and other activities. Our efforts will be supported by a strong Advisory Board and subcontractors with specific, targeted expertise. Overall, ComaWar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GREENHOUSE SOLUTION TO AVOID FILM COVER  U.V. AND SULPHUR DEGRADATION' (GREENAVOID).

assistant: **Innovation**

Greenhouse cultivation under plastic has allowed converting apparently unproductive lands in modern agriculture exploitations. Different types of plastic materials such as Poly Vinyl Chloride (PVC), Poly Carbonate (PC) and Low Density Polyethylene (LDPE) are commonly used for cladding of greenhouse structures. However, most of plastic polymer  films are prone to photo-degradation when exposed to UV radiation (290–400 nm) or even visible radiation (400–700 nm). In hot regions in combination with agrochemicals, degradation is a bigger problem. Durability is one of the aspects that most interest and worry to end users. Manufacturing of plastics resistant to treatments done in greenhouses are the battlefield of the companies in this industry and phytosanitary products such as sulphur and chlorine have become their greater enemy. Among these products burning sulphur is especially aggressive and the current method of application has a big impact in plastic degradation.GREENAVOID project aims to develop an innovative integrated solution combining a new polyethylene greenhouse plastic resistant to UV degradation in the presence of burning Sulphur with an improved Sulphur vaporizer designed to minimize the amount of product reaching the cover. Thanks to our integrated solution we aim to obtain a film with 3 years guaranteed durability in the presence of burning sulphur and a radiation of 145-150 KlAngleys/year, the average radiation Greenhouses suffer in South Europe. Moreover, it will be resistant to sulphur concentration in plastic of ≥3500ppm, chlorine concentration of ≥250ppm, with High NIR (near Infrared) and UV blocking, minimum PAR transmittance 85% and 35-40% haze.The impact of GreenaVoid solution will be bigger in the EU considering, not only the total  revenue of the S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a synbiotic product to modulate the Parkinson’s disease associated microbiome' in the context of a Horizon 2020 call.

assistant: **Objectives**

SyMPaBiome aims to develop a synbiotic, a mixture of live biotherapeutic bacteria and a prebiotic, to modulate the Parkinson’s disease (PD) microbiome, with the threefold aim to decrease (1) the intestinal (neuro-)inflammation and (2) gut permeability associated with PD, as well as to (3) decrease the production of a recently discovered archaeal metabolite linked to PD development and progression. This synbiotic regimen will be the first mechanism-based synbiotic formulation,  underpinned by functional read-outs from a unique gut-on-a-chip host-microbe interface model. PD is the second most common neurodegenerative disease, and remains incurable. Gastrointestinal symptoms precede the characteristic motor symptoms by years to decades and there is evidence supporting initiation of the disease by enteric inflammation and changes in microbial community composition and function. Enteric inflammation in PD is exacerbated by an increased gut permeability and mucus-foraging bacteria are more abundant in the PD microbiome, while fibre-degrading bacteria are decreased. This offers the opportunity to develop prophylactic or disease-modulating products to address these changes in at-risk individuals or PD patients. Recently, the archaeal metabolite 2-hydroxypyridone (2-HP), a co-factor of the hydrogenase in hydrogenotrophic methanogenic archaea, has been implicated in idiopathic PD aetiology. Here, a preventive or disease modulating strategy is proposed to induce a shift in the microbiome and metabolome of at-risk individuals or PD patients and decrease 2-HP production and its cytotoxic effects on the enteric nervous system. In view of this, we aim to develop a synbiotic product that can restore the metabolic profile and microbial community in PD patients and has a protective effec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'STIMBOY: Your STIMulating BOt'.

assistant: **Innovation**

Transcranial Magnetic Stimulation (TMS) is a tool to stimulate non-invasively the brain, employed in Research and Clinics (e.g. depression, chronic pain, stroke, dementia, etc).Low spatial resolution, time-consuming rigid protocol and the continuous need of the presence of an expert has dramatically contained TMS research impact and therapeutic diffusion.STIMBOY project objectives are: 1) improve the robot-TMS developed within the ERC RESHAPE project to realize a TMS-droid (STIMBOY) that fulfills the need of automatization and extreme easiness-of-use of non-expert TMS clinical end-user (clinical configuration), and the need of precision and flexibility of TMS scientist (research configuration); 2) show the commercial feasibility of the technology (from the perspective of a cost-benefit analysis through health economics), 3) design a route to market for the technology (including market analysis and competitive landscape), 4) strengthen the IP position, 5) investigate the likely regulatory roadmap and 6) draft an exploitation plan consolidated in a business plan.Robotic TMS research (e.g. >1100 TMS papers/year indexed by PubMed) and therapeutic market-size (2.5 billion € only for drug-resistant depression) is not covered by the few commercial devices, upon which STIMBOY will have several advantages: lower size and weight, automatic neuronavigation implemented by the robot itself, wider workspace, the possibility to perform double-coil protocols, higher safety due to torque sensors embedded in each joint and innovative features of the control algorithm, higher camera frequency and better performance/cost ratio. The project is implemented by the same multidisciplinary team that developed the ERC RESHAPE robot-TMS, with the help of a consultant for exploitation.STIMBOY will