RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating BOMOSA cage fish farming systems in reservoirs, ponds and temporary water bodies in Eastern Africa' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The BOMOSA Project will research the economic viability, social acceptance and necessary institutional environment of a technology that has been proven technically feasible over the last two years. BOMOSA is pioneering small-scale fish farming in Eastern Africa by establishing rural aquaculture networks (coordinated in a hub and plot system) to economically integrate aquaculture with agriculture. The BOMOSA system will form the basis of a socio-economic model contributing to poverty alleviation in Eastern Africa by providing supplementary high protein food and additional income to rural communities in Kenya, Ethiopia and Uganda. The 36-month project involves four European partners (two universities, a science academy and an NGO), six African partners; two Kenyan universities and fishery research centres from Kenya (2) and one each from Ethiopia and Uganda.The summarized scientific and technical objectives of the project are: Apply a participatory approach to define targets in terms of economic viability and social acceptability at community levels for the new BOMOSA plots Develop and validate an evaluation method using remote sensing to assess and characterize water bodies for use as potential BOMOSA plots Set up fourteen BOMOSA plots and optimise the technology in three types of small water bodies within four eco-zones across Kenya, Ethiopia and Uganda Evaluate locally available, agricultural by-products and cost-effective processing technologies as a resource for sustainable production of low-protein fish feed Determine requirements and make recommendations for a legal and regulatory framework based on potential veterinary, public health and environmental impacts of BOMOSA Develop capacity building and dissemination material for the local community , relevant authorit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure' in the context of a Seventh Framework call.

assistant: **Objectives**

Heart failure is common in Europe and its prevalence is increasing as our population ages. Despite major improvements in care since the early 90s, it is still related to a poor prognosis, an impaired quality of life and high health care costs. Many new therapies have failed to improve outcome further. One obvious reason is that the response to treatment is not homogenous. Treatment may need to be tailored to the individual patient. BIOSTAT-CHF aims to identify patients with a poor outcome, despite currently recommended therapy using information on demographics, gender, existing biomarkers, genetics and proteomics. Both genomic and proteomic analyses recently underwent major technical improvements, resulting in genome-wide analyses and detection of low abundance proteins. In BIOSTAT-CHF an index cohort of 2500 patients hospitalized with acute decompensated heart failure, will be recruited after initial stabilization. Treatment will be optimized according to the heart failure guidelines of the European Society of Cardiology with diuretics, ACE-inhibitors, betablockers and aldosterone antagonists. When patients are optimally treated, any change in symptoms and exercise tolerance will be evaluated. Patients will then be followed up for a mean of 18 months, and mortality and heart failure hospitalizations will be recorded. By using a systems biology approach, incorporating information from demographic, biomarker, genomic, proteomic, and the initial response to therapy, a risk prediction model will be designed, identifying patients with a poor outcome on currently recommended therapy. This model will then be validated in a real-life cohort of 2500 chronic heart failure patients. BIOSTAT-CHF will therefore be a major step towards personalized medicine. Identifying patients wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pathways of organic matter and its implication for biodiversity and sustainable uses in the white sea' (WOMP), addressing dissemination and exploitation.

assistant: **Impact**

By joint sea-going and land-based research, including exchange of personnel between laboratories, origin, transportation, transformation and nutritional role of particulate organic matter (POM) will be investigated in the White Sea by 3 Russian and3 EU member state institutions. Special attention will be paid to sea ice communities and macro algal remainders as POM sources in this Arctic environment. Benthic POM decomposition in the permanently cold deep waters will be analysed also for hydrological assessments of deep-water renewal.The role of POM in the food chains, including higher trophic levels (fish, birds), will be studied to explain biodiversity patterns. Together with results from examinations of local developments in uses of marine resources, the ecological baseline information from the project will be used to develop advisory scenarios for sustainable exploitation of the regional resources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gradual integration of REnewable non-fossil ENergy sources and modular HEATing technologies in EAF for progressive CO2 decrease' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EAF steelmaking is the key technology for decarbonised steelmaking, either in scrap-based plant by modification of existing processes for further decarbonisation, or as new EAF installations in decarbonised integrated steel works to (partly) replace the classical BF-BOF production. At same time the EAF is the most important example for modular and hybrid heating, already now combining electric arc heating with burner technologies. Consequently, it was selected as main focus of GreenHeatEAF for the Call „Modular and hybrid heating technologies in steel production“. GreenHeatEAF develops and demonstrates the most important decarbonisation approaches at EAFs including the use of hydrogen to replace natural gas combustion in existing or re-vamped burners or innovative technologies like CoJet. Furthermore, decarbonisation of EAF steelmaking by solid materials like DRI/HBI and renewable carbon sources like biochar is tackled.Technologies to re-optimise the heating management with maximum heat recovery of off-gas and slag employing new sensor and soft-sensor concepts as well as extended digital twins are developed: as result the extended CFD and flowsheeting models, and monitoring and control tools will prognose the influences of the different decarbonisation measures on EAF and process chain to support upcoming decarbonisation investments and to enable the control of decarbonised hybrid heating with maximum energy efficiency. GreenHeatEAF combines trials in demonstration scale, e.g. in combustion- and EAF-demo plants, with validations in industrial scale  and digital optimisations with high synergy. Thus, it completely follows the Horizon Twin Transition and Clean Steel Partnership objectives and the target to progress decarbonisation technologies from TRL 5 to 7. This synerg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Pannexin1 nanobodies for the clinical treatment of liver disease'.

assistant: **Objectives**

Pannexin1 (Panx1) channels mediate the exchange of biochemical messengers between the cytosol of a cell and its extracellular environment. This type of cellular communication underlies cell death and inflammation, both which are associated with a plethora of diseases. Closing pannexin channels therefore seems an interesting therapeutic strategy. In this respect, the ERC Starting Grant project CONNECT has demonstrated that peptide-based inhibition of Panx1 channels counteracts the manifestation of acute and chronic liver disease. However, these peptides cope with stability issues thus impeding clinical application. No other types of appropriate Panx1 channel inhibitors are available today despite their promising therapeutic potential. The present CONNECT-2-CLINIC project will meet this urgent need by generating specific and in vivo-applicable Panx1 channel inhibitors. For this purpose, nanobodies targeted towards Panx1 will be produced using unprecedented protocols that combine DNA immunization with new nanodisc technology. Panx1 nanobodies will be tested in vitro for their capacity to inhibit Panx1 channels and to reduce cell death and inflammation. They will be subsequently tested in a human-relevant mouse model of cholestatic liver disease. This technology track will be aligned by a 3-phase business track in order to analyze and create market value. By doing so, the CONNECT-2-CLINIC project will provide solid proof-of-concept for further pharmaceutical development and clinical application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'smart and multiFunctional 3D printable prO-Regenerative biologiCal matrix modulating mEchanotRansduction as advancEd theraPy to treAt skIn chRonic wounds' to be submitted under Horizon Europe.

assistant: **Abstract**

Due to population lifestyle changes, i.e. obesity, diabetes and aging population, chronic wounds (CW) which fail to follow the typical healing process is a major medical socioeconomic challenge. Current wound management is clearly insufficient and advanced therapies failed in keeping their promise of reliable skin regeneration. The aim of FORCE REPAIR is to develop a smart and multifunctional wound dressing providing pro-regenerative environment and mechanical stability to treat CW. Thus, FORCE REPAIR will combine state-of-the-art technologies in a biological scaffold tailored to patient’s needs: (1) Antibacterial and bioadhesive bioink with antibiotics and anti-inflammatory loaded nanocapsules, (2) Elastin like polypeptides promoting innervation and vascularization (3) Wharton Gel Complex preventing oxidative stress and boosting key extracellular matrix proteins. Also, the dressing activated by UV light will induce contractile force to help wound closure and activate skin regeneration. A customized 3D bioprinter with a user-friendly 3D trajectory software will help to strategically placed the biological compounds to timely address and mitigate the degenerative process occurring in CW, i.e. infection, inflammation, tension forces to promote skin regeneration. The 3D printed dressing will be tested in relevant in vitro model with a human exudate library and testing relevant key healing steps (i.e. re-epithelization, angiogenesis, cell proliferation…). Selected candidates will be tested in vivo on pig CW models and mice with bacterial infection. To ensure translation to clinical practice and reach patients, regulatory framework, HTA and a business model will be defined for a viable exploitation strategy that will decrease economic burden of wound care management and impro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Women’s labour activism in Eastern Europe and transnationally, from the age of empires to the late 20th century'.

assistant: **Innovation**

ZARAH explores the history of women’s labour activism and organizing to improve labour conditions and life circumstances of lower and working class women and their communities—moving these women from the margins of labour, gender, and European history to the centre of historical study.ZARAH’s research rationale is rooted in the interest in the interaction of gender, class, and other dimensions of difference (e.g. ethnicity and religion) as forces that shaped women’s activism. It addresses the gender bias in labour history, the class bias in gender history, and the regional bias in European history. ZARAH conceives of women’s labour activism as emerging from the confluence of local, nation-wide, border-crossing and international initiatives, interactions and networking. It studies this activism in the Austro-Hungarian and Ottoman Empires, the post-imperial nation states, and during the Cold War and the years thereafter. Employing a long-term and trans-regional perspective, ZARAH highlights how a history of numerous social upheavals, and changing borders and political systems shaped the agency of the women studied, and examines their contribution to the struggle for socio-economic inclusion and the making of gender-, labour-, and social policies.ZARAH comprises, in addition to the PI, an international group of nine post-doctoral and doctoral researchers at CEU, distinguished by their excellent command of the history and languages of the region. Research rationale, research questions, and methodological framework were developed through an intensive exploratory research phase (2016–2017). ZARAH is a pioneering project that consists of a web of component and collaborative studies, which include all relevant groups of activists and activisms, span the whole region, and cover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phytoremediation of contaminated soils and groundwater using mediterranean plants' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

In this project the phytoremediation capabilities of specific salt-tolerant Mediterranean species on selected organic contaminants is to be investigated. In particular, we are interested in the remediation of (i) nitroaromatic explosive residues in the shooting range area of the Maleme shooting range (located next to the seawater); and (ii) petroleum residues in north-western coastal areas of Crete which are due to past oil-spill accidents or illegal dumping activities. In terms of plants, we are focusing on indigenous salt tolerant plants such as the partially salt tolerant variety of oleander or Tamarax sp.. Currently, we have the expertise and equipment in place to analyze soil or aqueous samples and to do basic monitoring of key metabolites within the plant. However, we do need the additional expertise in the physiology of salt-tolerant plants and tracking the fate of xenobiotics in the plant system (contaminant transport and subsequent metabolism and/or sequestration within the plant). The ultimate objective is the development of efficient and cost-effective remediation technologies for contaminated areas with increased salt content. The Marie-Curie Fellow should have a Ph.D. in Plant Physiology, Agronomy, Agricultural Engineering, or equivalent and a good publication record as well as expertise in the project areas. The Fellow is expected to carry out innovative phytoremediation research and collaborate with staff members in the laboratory. Excellent knowledge of the English language is required. At the time of selection, the fellow must be 35 years old or less (allowance is made for childcare or military/civil service) and cannot be of Greek nationality or having worked for more than 12 months during the past two years in Greece. The work will be carried out at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ORAL SPAWNING INDUCTION FISH. NON INVASIVE CONTROL OF REPRODUCTION IN FISH BY DIETARY DELIVERY OF THE BIOACTIVE PEPTIDE GNRH""' in the context of a Fourth Framework call.

assistant: **Objectives**

There is a rise in world population and an increased demand for feed fish and shellfish. Against this, fish catches are decreasing. There will therefore be a direct need for the growth of aquaculture and as a consequence the markets for fish therapeutics will expand. The demand to gain the ability to control the reproductive cycle of a given species has become essential. This project brought together partners from France, Netherlands, and Belgium, specialised in different fields including; pharmaceuticals, law, fish nutrition, endocrinology and aquaculture aiming at the industrial application of microcapsule delivery. The project started with fundamental research on the intestinal uptake of bioactive peptides and proteins that had been carried out earlier in the Fisheries and Aquaculture Research Programme (FAR) of the EC. It resulted in an efficient microencapsulate oral delivery system for uptake of GnRH (Gonadotropin release hormone) by fish. This project aimed to further develop this 'in feed' or dietary delivery form of the bioactive peptide GnRH which will provide a man-made control of reproduction.The objective of the project was to valorise a dietary delivery system of GnRH to fulfil the growing demand of the aquaculture sector concerning broodstock management and control. The introduction of oral or dietary GnRH-therapy will boost the development of those species which do not mature in artificial conditions such as flatfish, wells and sturgeon. It is therefore expected that this diversification will lead to more jobs in the aquaculture industry. The veterinary industry is also looking for easier ways to handle delivery forms for their vaccines, antibacterials, immunostimulants. The pilot work was carried out on three species with different feeding habits, namel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Scenarios for integration of renewables in a european cities network (SIREN)' (SIREN).

assistant: **Innovation**

The actions proposed will produce effects within and outside the network of Agencies and Cities originally involved: Within the Network SIREN creates 4 municipality level nodes (links among local administrators, technology providers and beneficiaries, market actors) to apply and validate SIREN methodology, helping the Energy Agencies in redefining their role and increasing their competencies in the RES promotion; stimulates exchange among the different R&D projects approaches and fosters the dissemination and integration of RE technologies in the European municipal energy systems, maximising common elements and approaches and creating synergies and complementarities to be shared within the Network; provides even a follow-up to the cluster of 8 R&D projects supported to facilitate a sustainable implementation scheme according to local needs and future expected requirements. Outside the Network: SIREN, through the participation-based EASW methodology, promotes interaction at European level, among entrepreneurs, residents, experts and politicians of different geographical areas to assess the non-technical barriers to new and RE technologies. SIREN, providing all the information necessary to combine the technological offer with the citizens demand, supports the creation of a relevant market for the selected RE technologies cluster.