RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of TAM receptors in the differentiation and function of tissue macrophage subpopulations: Implications for the development of inflammatory disease' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Chronic inflammation and dysregulation of the immune response underlie multiple human pathologies, including rheumatoid arthritis and systemic lupus erythematosus. Autoimmune disorders comprise more that 50 distinct diseases and affect about 5% of the population in Europe. Thus, chronic inflammation and autoimmunity are one of the thematic priorities within FP7 Cooperation Health (‘Other Chronic Diseases’).The TAM family of receptor tyrosine kinases - Tyro3, Axl and Mer – together with their activating ligands Gas6 and Protein S - play pivotal roles in immunomodulation and regulation of tissue homeostasis and TAM-deficient mice present systemic inflammation and autoimmunity. However the molecular mechanisms underlying these phenomena remain poorly understood. We have recently discovered that TAM signalling is essential for the development of macrophages in the Marginal Zone (MZ) of the spleen. The heterogeneity of the macrophage lineage has long been recognized, but the developmental origin and function of tissue macrophage subsets have not been clarified.The main objective of this research proposal is to characterize the mechanism/s by which TAM receptors participate in splenic MZ macrophages differentiation and function and ultimately, their contribution to human immune disorders. To achieve this aim I propose to use cutting-edge technologies in gene targeting, cell biology, immunohistochemisty, imaging and bioinformatics. The project will involve numerous mouse models deficient in both the TAM receptors and their ligands and novel in vivo approaches.This proposal, with a great clinical relevance, seeks to link two issues that remain unexplored: 1) the role of TAM receptors in the immune response and autoimmune diseases, and 2) the molecular mechanisms leading to diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Label-free miniaturised dna biochip'.

assistant: **Objectives**

DNA hybridisation has the potential to detect target sequences in a sample, this has application in identification of pathogens and viral or genetic disorders. Conventional approaches for monitoring DNA hybridisation often involve use of a fluorescent label. We propose to develop a miniaturised micro array system using impedance and surface plasmon resonance (SPA) interferometry for a label-free method of identification of pathogens in the food and environmental sectors. Impedance based measurements will be carried out on a DNA biochip composed of a 4x4 element array interdigitated electrodes and heater elements. SPR interferometry information is obtained by creation of an interference pattern and allows micro array sensing. The DNA biochips will be incorporated into a micro fluidic system and allow automated monitoring of DNA hybridisation and discrimination of alleles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Will this fire burn out? The topos of lovers' separation in the Italian Renaissance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project aims to achieve the first in-depth study on the lyrical topos of lovers’ separation (i.e. when a lover has to go away and therefore leaves her/his beloved for some time) in the Italian Renaissance. The study is meant to improve our knowledge about: 1) the different ways to read and re-use the tradition in the Renaissance; 2) the role of Petrarch as an authority in Renaissance love literature, also in comparison to other models; 3) the interaction between lyrics and love treatises, as well as between literature and philosophy in the conception and representation of love in the Renaissance. For such a goal, Dr. Favaro will analyze the topos of lovers’ separation in Renaissance lyrics and love treatises, paying attention to their mutual interaction, as well as to the relationship with the previous literary tradition and with philosophical sources (especially Neoplatonism). He will also achieve the commented editions of two little-known Renaissance dialogues entirely devoted to the subject of lovers’ separation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dissolving microneedle array patch-based psoriatic immunotherapy using nanoparticles'.

assistant: **Concept**

Psoriasis, an autoimmune disorder characterized by keratinocyte hyperproliferation, predominantly manifests as plaque-type psoriasis, with a majority of cases being mild to moderate. Current treatment approaches, such as topical therapy, often fall short due to limited skin permeability. Systemic drugs and biologics, while effective, pose risks associated with high doses. Addressing mild psoriasis presents the challenge of overcoming limited skin permeability and minimizing systemic drug toxicity. Microneedle Array patches (MAPs) offer a promising alternative. They breach the stratum corneum, facilitating intradermal drug delivery, resulting in higher localized drug concentrations compared to systemic or topical administration. Given the pivotal role of TNF-α in psoriasis, I bring expertise in various MAP fabrication techniques, nanomaterials for drug and mRNA delivery, and their applications. By collaborating with the host, we aim to develop an innovative nanomedicine-based strategy. This approach involves encapsulating TNF-α inhibitors in calcium phosphate nanoparticles using flame spray pyrolysis and loading them into MAPs. The research will encompass various parameters, including size, encapsulation efficiency, release kinetics, mechanical strength, morphology, safety, and in vitro efficacy assessment. Beyond the research project, I will engage in personal development courses, gain exposure to state-of-the-art laboratory facilities, and participate in conferences. Additionally, I will mentor Master's and Ph.D. students, honing my project management skills, and collaborate with industry experts and clinicians to explore the formulation's potential.


**Keywords:** Flame aerosol nanoparticle synthesis, microneedle array patches, psoriasis, nanocarrier, immunotherapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '8th European symposium on drosophila neurobiology-NEUROFLY2000 San Juan (Alicante), Spain' in the context of a Fifth Framework call.

assistant: **Objectives**

The rapid progress on Neuroscience depends on the choice and proper use of suitable experimental models where to address relevant questions. Following the success of Drosophila as a model in Development, neuroscientists are turning to this system and its use is yielding major contributions in recent years. This proposal is for the organisation of this 8th European Symposiurn on Drosophila Neurobiology (Neurofly2000).This meeting is timely because the completion of the Drosophila Genome Project this year will provide the information linking the sequence to physical and genetic maps as well as gene predictions. This event, in conjunction with new technological developments in this:field, will open an unprecedented range of possibilities for Neuroscience research that deserves to be discussed in order to design suitable strategies to approach relevant neurobiological and related biomedical problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nmr facility for paramagnetic biomolecules' to be submitted under Fifth Framework.

assistant: **Abstract**

Description:The EU Large Scale Facility PARABIO, established in Florence in the scientific Campus of the University in Sesto Fiorentino, is part of the cluster of Research Infrastructures for Biomolecular NMR. The uniqueness of the infrastructure lies in the widest range of magnetic fields available, which allows a user to combine the two main NMR approaches, namely high resolution NMR and relaxometry. The infrastructure is equipped with an 800 MHz spectrometer, and there are agreements to install a 900 MHz instrument. The infrastructure owns a 200, equipped with CP-MAS accessories, a 400 MHz, a 500 MHz equipped with a CryoProbeÔ, a 600 MHz and two 700 MHz spectrometers. In addition to high field NMR spectrometers, the Florence infrastructure is equipped with several instruments to perform low-field NMR studies. A high-resolution variable field instrument covers the 6-90 MHz field range. A Field Cycling Relaxometer, operating in the 0.01-50 MHz range and a prototype Fast Field Cycling Relaxometer, operating in the 0.001-20 MHz range, are available. With the EC support, PARABIO staff is working at the development of a High Sensitivity Fast Field Cycling NMR (HPRI-CT-2001-50028) that is expected to be available in one year. A parallel computer, a PCs cluster and a large number of networked UNIX and Linux workstations are available for structure determination and refinement and for data analysis in general.Application:Main results:PARABIO gave access to 49 Users from 11 countries, for a total of 952 days spent at the Infrastructure as a result of 76 visits. The spectrometer days delivered were 515, divided in 249 High-Field and 266 days for Low-Field instrumentation. The results of the projects carried out at PARABIO during the present contract were of relevant interest fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced signalling and automation system - Completion of activities for enhanced automation systems, train integrity, traffic management evolution and smart object controllers' (X2Rail-4).

assistant: **Concept**

X2RAIL-4 is the 4th project of the Shift2Rail members in the IP2 “Advanced Traffic Management & Control Systems” domain and it aims to continue the research and development of key technologies within the following Technology Demonstrators (TDs): -Railway line capacity increase (ATO up to GoA4)–TD2.2 (WP3, WP4, WP5): Finalize the activities started in X2Rail-1 by completing the GoA2 Specification. Develop ATO GoA4 prototypes. Integrate and test Obstacle Detection devices and “environment sensors”  in cooperation with IP5 TD5.1.3.-On-Board Train Integrity–TD2.5 (WP6, WP7):  Finalize the activities started in X2Rail-2. Define, develop and test complete On-Board Train Integrity system prototypes able to be applied in every train typology (i.e. Passengers and Freight trains with wired and wireless communication). -Traffic Management Evolution–TD2.9 (WP8, WP9, WP10): Finalize the activities started in X2Rail-2. Define, develop and test various elements of a Traffic Management System platform. Define and design a communication platform (Integration Layer) using standardized data structures and processes to manage the Communication/Data exchange between different services/clients and supporting TMS applications connected to other multimodal operational systems.-Smart radio-connected all-in-all wayside objects–TD2.10 (WP11, WP12): Finalize the activities started in X2Rail-1.Develop, implement and validate technical demonstrator. Develop and test prototype providing data exchange between trackside equipment and signalling devices via wireless connection; reduction of required cabling; increase on the availability of Maintenance Data, reduction of maintenance costs; support to preventive maintenance.


**Keywords:** Shift2Rail, Innovation Programme 2, Automatic Train Operation, On
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolution of the Non-Uniformitarian Earth', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project will use a set of innovative techniques to study the two major events that precede classical, uniformitarian geology. We will search for crystallised remnants of the primordial terrestrial magma ocean and examine the consequences of our observations for mantle dynamics. Crystallisation of the dominant lower mantle phase, bridgmanite, imparts a Mg and Si isotopic fingerprint to cumulates and evolving liquid of the magma ocean. Identifying the relicts of these small but distinctive fractionations requires application of our bespoke, high precision analytical protocols. As an integral part of this work, we will undertake coupled first principles calculations and petrological experiments to provide a benchmark documentation of the isotopic fractionations experienced by these two most abundant cation-forming elements in the silicate Earth. We will also date the global onset of plate tectonics from complementary geochemical signatures in two little-studied detrital minerals; Pb enrichment in continental K-feldspars and Mo depletion in rutiles from exhumed fragments of subducted crust.  This work uses ground-breaking methodologies made possible by our unique, tribrid (mass-filter:collision-cell:multicollector) mass-spectrometer, Proteus.  We will further develop this technology in collaboration with Thermo Fisher to produce a yet more capable next generation instrument.  Our tribrid mass-spectrometer allows us to date single, detrital K-feldspars by laser ablation, using Rb-Sr internal isochrons constructed with analyses of host feldspar and sodic perthite exsolutions.  Coupled with in situ Pb isotope analysis, we can calculate the U/Pb of the feldspar’s crustal protolith, which diagnostically tracks contributions from subduction.


**Keywords:** Isotopic fractiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Establishment of an Agricultural Genomics Centre in Cyprus'.

assistant: **Concept**

The objective of AGRICYGEN is to establish a world class Centre to conduct high-throughput Agricultural Genomic studies in order to support the advancement and sustainability of the livestock and feed production sectors in Cyprus. The project addresses the specific scope of the H2020 CSA-Teaming call by aiming to provide, currently lacking, broad-range technological and scientific foundations for a Centre of Excellence to support activities of huge economic value to Cyprus. AGRICYGEN also has multifaceted alignment with the Smart Specialisation Strategy of Cyprus. The Centre development shall increase Cyprus' international visibility and competitiveness in cutting edge agricultural research, by enhancing research capacity in the area of genetics and genomics and through its applications within the livestock and agricultural production industries. It will also strengthen collaborations and initiate new collaborative links for sharing expertise and knowledge in areas associated with Agricultural Genomics, and will create an ever-expanding, well-educated task-force of researchers in this area. The Centre establishment and consolidation will be achieved by capitalizing on existing local research capabilities of three Cypriot Institutions, and through effective collaboration with three advanced European institutions that are world leaders in animal, plant and microbial genetic and genomics research. This long-term partnership will create the conditions for innovative research, and for extensive service and training provisions to animal, plant and other production chains. The Centre’s excellence will be strengthened through collaboration with the advanced partners for the development of a Cyprus-based postgraduate programme in Agricultural Genetics and Genomics, affiliated to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative Biodegradable Poly(ionic liquid)s for Bioelectronics' (2014-2020).

assistant: **Innovation**

Poly(ionic liquid)s or PILs are expanding classical property profiles of polymers and stirring great interest in the development of diverse areas, as green chemistry, energy, biotechnology, materials or membrane science. One of the common concerns of PILs consist of its biodegradability due their bioaccumulation and negative effects to the environment and the human body. The main goal of this project is to develop the first generation of biodegradable PILs. The most successful biodegradable polymeric backbones such as polycarbonates or polyesters will be combined with readily biodegradable cholinium-based ionic liquids. The polymers will be synthesized by controlled ring-opening polymerization using recently developed organocatalysis tools. The most promising biodegradable PILs will be investigated as ion conductive soft membranes in bioelectronic devices.This MSCA Fellowship will open the best career possibilities for the Experienced Researcher (ER), and excellent young female scientist. After a successful PhD and 2 years Post-Doc in ionic liquid-based materials and gas separation membranes at ITQB-Universidade Nova de Lisboa (Portugal), she decided to move to a different environment, where she can exploit all her materials science expertise. The Innovative Polymers Group directed by Prof. David Mecerreyes at POLYMAT-University of the Basque Country (Spain) is one of the top-class groups in the emerging area of PILs. This multidisciplinary project will broaden the scientific knowledge of the ER and help her to grow and expand her network in order to reach a future group leader position in the materials science field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SOLAR ADSORPTION REFRIGERATOR WITH THIN-LAYER/ENHAMCED ADSORBENT' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Increased energy costs, the uncertainty of fossil fuel availability, and climate change concerns, have necessitated the quest for renewable energy resources. Solar adsorption systems are quiet, simple to operate, and can last for a long time. However, they have low cooling power density, and subsequently have to be bulky compared to similar solar thermal systems offering the same performance. This can increase their initial costs, especially for small and medium sized systems, thus reducing their uptake. Currently researchers have successfully tackled this issue by, for instance, using more than one adsorbent bed to adopt a continuous cycle, and using forced cooling for the adsorber bed and condenser. These have not resolved the bulk/cost issues, however. This innovative Fellowship will apply a thin layer nano-particles embedded adsorbent, nano-fluid based refrigerants and selectively absorbing solar plate collectors to the system. We will develop a robust simulation model to help with the design process. The system will be partly built using a novel diffusion bonding process that enables dissimilar materials to be joined seamlessly. We will test the adsorption properties of the novel adsorbent materials and apply them to the refrigerator. We aim to deliver a solar adsorption refrigerator that employs nano-technology and novel manufacturing methods, meets the performance improvements currently achievable but not with the bulk and complexity. We expect scholars and industry to also apply the technology demonstrated to several other uses, and for them to be more accessible to the general public. The Fellow has all the necessary skills and experience required (including chemical adsorption, thermodynamics, heat & mass transfer) while the host lab has all the infrastructure