RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'INTEGRATED TELESCOPIC TOWER AND EVOLVED SPAR FLOATING SUBSTRUCTURE FOR LOW-COST DEEP OFFSHORE WIND AND NEXT GENERATION OF 10MW+ TURBINES'.

assistant: **Innovation**

TELWIND unites a strong complimentary team of renowned European companies and research institutions, which join forces to develop a revolutionary integrated floating offshore system. The concept, which has already undergone trial tank testing with overly positive results, shall enable a radical cost reduction both in terms of material usage and required means and operations. The system has been conceived in a holistic approach to the overall substructure, tower and turbine, generating ground breaking synergies between the integrated elements to specifically address the particular requirements of offshore wind, focusing in the capacity for low-cost industrialization in the inshore construction and offshore installation processes. The Telwind concept integrates a novel floating substructure and a pioneer self-erecting telescopic tower. The former provides all the performance advantages of a spar-buoy substructure while allowing for qualitatively lower material usage, the latter enables a full onshore preassembly of the overall system and a highly beneficial reduction of offshore works and auxiliary means. Together they overcome the limitations imposed by the available inshore infrastructure and offshore heavylift vessels, and thus generate a fully scalable system, perfectly fitted for the effective integration of the next generation of extremely large (10MW+) offshore wind turbines which are key to enhance the reduction of the Levelised Cost of Energy (LCOE). The system will also profit from the proven structural efficiency and economy of precast concrete, a material particularly well suited for low-cost industrialized production of repetitive units. Robust, reliable and virtually maintenance-free marine constructions result, reducing OPEX costs, greatly increasing durabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering the functional differences between Small Ubiquitin MOdifiers SUMO-1 and SUMO-2/3 pathways in normal and stress conditions' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Small Ubiquity-related Modifier (SUMO) is a member of a ubiquity-like protein family that regulates cellular functions of a variety of target proteins. Whereas yeast have a single SUMO, essential for life, mammals have three, SUMO-1, -2 and -3. Whether they are all required, have overlapping functions and can complement or replace each other is currently unknown. Moreover, while SUMO-1 has been extensively studied, little is known about its two close homologues SUMO-2 and SUMO-3. In particular, no specific substrate for these is forms has-been found so far. Nevertheless SUMO-2 and SUMO-3 exhibit specific and important characteristics, the main one being their increased conjugation in response to various stresses. The objective of the proposed activity at the Max Planck Institute" in Munich, Germany, under the supervision of Dr. Franker Melcher, is to study the functional differences between SUMO-1 and SUMO-2/3 is forms in normal and stress conditions. Joining Dr. Franker Melchers group will give me a unique opportunity to acquire new skills, especially in biochemistry, and participate to the emergence of this new field of biology that is ubiquity and ubiquitin-likeregulation of biological processes. The expertise I will obtain with Dr Melcher will be vital for carrying out my future career as independent researcher."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chromosomal inversions in Atlantic herring and adaptation to changing sea water temperature', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Large chromosomal inversions have been increasingly linked to local adaptation in natural populations. Despite their importance, there is current debate about what evolutionary forces maintain inversion polymorphisms in natural populations, particularly regarding the interplay between balancing and divergent selection. Furthermore, limitations of sequencing technologies often result in poor characterization of inversion breakpoints obscuring our understanding of their functional impact. INVERT2ADAPT will focus on Atlantic herring (Clupea harengus) as a model system to study the contribution of chromosomal inversions to local adaptation using multiple genomics tools. First, I will characterize the chromosomal inversions and date their origin relatively to the evolutionary history of Atlantic herring using comparative genomics and phylogenomics. Second, I will study the selection regimes that maintain the inversions across a gradient of sea water temperate using population genomics. Lastly, I will pinpoint the genes and regulatory elements within the inversions that are involved in adaptation to sea water temperature using gene expression and functional genomics. The project will allow to better understand how Atlantic herring is able to survive across a wide range of sea water temperature in the Atlantic Ocean. A clear establishment of the link between linking genotype, phenotype and environment is important to understand how Atlantic herring might adapt to changes in sea water temperature induced by global warming. INVERT2ADAPT will also contribute to a better understanding of how structural variation, including large chromosomal inversions, contribute to adaptation in natural populations. The project will be implemented in Uppsala University under the supervision of Pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'a disruptive implantable neurostimulator for the treatment of epilepsy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The objective of this innovation project is to develop a disruptive implantable neurostimulator for the treatment of epilepsy with thegoal to place it on the market by 2021.Neurostimulation is a $4.7 billion market and one of the fastest-growing areas of medicine, that has been approved for the treatmentof several neurological disorders. Among these, epilepsy is the most frequent nervous system disease. Of the 50 million peoplesuffering from epilepsy, with 3.7 million in Europe, approximately one third of them are resistant to medication but respond well tothe neurostimulation.Neurostimulators are small implanted devices stimulating nerves or brain tissue. The innovative aspects of the project are based on aSynergia Medical’s patented concept and consists in replacing wires by optical fibres.The innovation will improve the traditional therapy and brings the main following competitive advantages:- it renders the neurostimulator compatible with magnetic resonance imaging (MRI) diagnosis- it provides a highly tunable stimulation and ultra low power consumption- it improves safety due to electrical isolation and allow for a smaller size implantThe main objective of this feasibility study is to complete the business plan by:- completing a market study and refining specifications of the neurostimulator with key opinion leaders in the field of epilepsy;- manufacturing prototypes of neurostimulators to validate stimulation capabilities, low power consumption, compactness, opticalchain efficiency and estimate production costs;- refining the development and production planning, including budget and human resources, based on cost estimates and testresults;- finalizing the selection of subcontractors involved in the production chain;- filing additional patents and realizing a compl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Research and Innovation Strategy for the CIVIS Alliance'.

assistant: **Innovation**

RIS4CIVIS is proposed by the CIVIS European University Alliance members: Universities from eight countries (BE DE EL ES FR IT RO SE), led by Aix-Marseille Université. In line with the Horizon2020 Work Programme objective to contribute to European Universities’ Research & Innovation (R&I) dimension, RIS4CIVIS will enable (A) the CIVIS Alliance and (B) European universities to maximise their potential to address 21st Century challenges through world-class R&I.For CIVIS to achieve this objective, we will develop an integrated, long-term R&I Strategy, based on our complementary strengths, but also addressing obstacles that stand in the way of deeper R&I cooperation in the following six fundamental areas: 1/ a Common R&I Strategy; 2/ Sharing infrastructures; 3/ Reinforcing Academia-Business R&I Cooperation; 4/ Strengthening Human Capital; 5/ Mainstreaming Open Science; 6/Embedding Citizens and Society.For each of these areas, we will: - Through Benchmarking, establish the current situation across our Alliance and define the ideal endpoint;- Through Consensus-Building, identify Roadmaps to reach these endpoints and to remove legal, regulatory, financial or other barriers in the short-, medium- and long-term: where the removal of barriers is not in our hands, develop Recommendations to national and European policy-makers on the way forward;- Through Case Studies, start implementing our Roadmaps, thereby testing and validating them.The knowledge gained in each of these activities, across all six areas, will inform our development of the CIVIS Research & Innovation Strategy. For other European universities, we will synthesise our six Roadmaps, as well as the benchmarking, consensus-building and case studies that went into them, into a CIVIS Institutional Transformation Model to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exocyclic adducts as new risk markers for DNA damage in man' in the context of a Fourth Framework call.

assistant: **Objectives**

Exocyclic base adducts in human DNA such as the etheno (epsilon) adducts epsilon dA and epsilon dC are formed by environmental and endogenous genotoxins that are generated from oxidative stress, dietary factors and metal storage diseases. A third epsilon-adduct, epsilon dG, has been detected in rodent tissues upon exposure to epsilon-adduct forming chemicals. To assess the role of these promutagenic DNA lesions in human malignant diseases, four representatives of epsilon-adduct generating chemicals (trans-4-hydroxy-2-nonenal,2-chloro-acetaldehyde, chloro-ethylene oxide and vinyl carbamate, a reactive metabolise of urethane) will be investigated by the following approaches: (i) Quantification of epsilon dA and epsilon dC in cell/tissue DNA of humans, mice, Drosophila and E. cold by ultrasensitive methods, recently developed by study partners; development of a new sensitive method for analysis of epsilon dG in human DNA. (ii) Studies on diet-related formation of epsilon-adducts in rodents, and the proportionality between epsilon-adducts in DNA of white blood cells vs. those in breast and colon; comparison of DNA epsilon-adduct levels and repair activities in lung tissues and lymphocytes from lung cancer patients. (iii) Identification and purification of repair enzymes that remove of epsilon dG and epsilon dC in human cells and in E. coli; construction of E. cold repair-deficient strains for defining mutation specificity of epsilon bases;  correlation of the persistence/repair of epsilon-bases with biological endpoints (free radical induced cytotoxicity; cancer) measured in knock-out mice deficient in repair (ADPRT) and tumor supressor (p53) genes. (iv) Development of methods for analyzing formation/repair of DNA epsilon-adducts at specific target gene (p53) and at nucleot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spin-orbit interaction and other relativistic effects on magnetic resonance spectral parameters' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content We investigate relativistic corrections applied to quantum chemical calculations of NMR and EPR parameters, and the roles played by scalar relativistic and spin-orbit (SO) interactions in them. A practical computational tool (based on DFT and the deMon-NMR software) is realised for the spectral parameters of large systems containing heavy elements and transition metals. Gauge-including atomic orbitals are used for the nonrelativistic nuclear shielding tensor and its SO-correction. Effective one-electron SO-operators to be used with quasirelativistic effective core potentials are implemented. Work towards a relativistic all-electron scheme is initiated. The methods will be applied to molecules and clusters containing noble gas, halogen, chalcogen and transition metal atoms. Applications to solids are investigated using periodic boundary conditions and plane wave expansions. Training content (objective, benefit and expected impact) Objective: Thorough acquaintance in the usage and development of modern DFT in this field. Benefit:Work in the leading group of the field, and access to its scientific cooperation network. Expected impact: Ability to independently lead fundamental and application work in close contact with experimental research. Links with industry / industrial relevance (22) The host group collaborates with BASF AG on the NMR chemical shifts in heavy-metal complexes in the context of catalytic processes. The proposed research is essential for success of the cooperation, as an improved treatment of spin-orbit effects is mandatory to achieve the desired computational accuracy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Applying European market leadership to river basin networks and spreading of innovation on water ICT models, tools and data', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

WaterInnEU’s primary vision is to create a marketplace to enhance the exploitation of EU funded ICT models, tools, protocols and policy briefs related to water and to establish suitable conditions for new market opportunities based on these offerings. WaterInnEU will build upon existing knowledge bases and platforms developed in previous projects but will provide new concepts, connections, and components that are essential for a marketplace to work.The primary goals can be detailed in five major objectives:a) Gather the outcomes of previous European funded projects, and contribute to their dissemination and exploitation to be used as an instrument for supporting the implementation of the Water Framework Directive (WFD). b) Assess the level of standardization and interoperability of these outcomes as a mechanism to integrate ICT-based tools, and incorporate open data platforms and generate a palette of interchangeable components that are able to use the water data emerging from the data sharing processes and data models stimulated by initiatives such as the INSPIRE directive.c) Create the marketplace as a service: a forum formed by water research projects representatives, stakeholders in the water domain, and companies (in particular SMEs), who are capable of moving current products into the market and offer them to, for example, river basin managers, at different levels. The user segment will mainly benefit from the capability of the water partnerships (e.g. the Global Water Partnership), in bringing together a wide variety of water sector stakeholders and practitioners such as decision makers, public and private users, local, regional and international entities, multidisciplinary stakeholders.d) Build an open virtual marketplace that includes the Water Knowledge Portal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Workflow management for simultaneous engineering networks'.

assistant: **Concept**

The overall objective of the SIMNET project is to develop an advanced standard-based workflow management solution for simultaneous engineering within extranets.For this purpose the research will identify, - Intelligent mechanism for linking engineering workflows to dynamic product data for immediate determination of the simultaneous engineering processes to be carried out as a result of modifications to the product structure. - Enhancement of the workflow module of a commercial PDM-system with the aim of managing complex simultaneous engineering networks. - Development of a standard interface to commercial business process modelling tools. - Open PDM workflow architecture in compliance with the WfMC and STEP standards. - Extranet solution for engineering networks based on Internet technology in order to overcome the heterogeneous infrastructure for information exchange between simultaneous engineering units, giving special attention to security mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PanCareFollowUp: Novel, patient-centred survivorship care to improve care quality, effectiveness, cost-effectiveness and accessibility for survivors and caregivers'.

assistant: **Innovation**

The 5-year survival for children with cancer increased from 30% in the 1970s to more than 80% at present. There are up to 300,000 childhood cancer survivors in Europe and this number is increasing. Years after treatment, childhood cancer survivors are at high risk for developing health and psychosocial late effects, resulting in excess morbidity and mortality compared the general population. The impact on the quality of life (QoL) of survivors and their families, as well as the societal and economic burdens, are significant. However, these impacts can be reduced by long-term survivorship care to detect treatable disease at an early phase and start timely interventions to preserve health, improve QoL, as well as coordinate specialised care and empower survivors. Implementing follow-up care, especially for young adult and adult survivors of childhood cancer, has proven challenging across Europe. These survivors have left paediatric care and most of them have no opportunity to visit experts in survivorship care. To improve survivorship care for these survivors across Europe, PanCareFollowUp will conduct a prospective cohort study to assess effectiveness, value, cost effectiveness and feasibility of the PanCareFollowUp Care intervention, a person-centred approach to survivor follow-up care based on international clinical guidelines for surveillance of late effects. PanCareFollowUp also includes the development and assessment of a personalised, guideline-based eHealth lifestyle intervention. Ensuring that the PanCareFollowUp interventions are used in the real world is paramount to achieving enduring improvements to survivorship care. Hence, the project includes the development of materials to support sustainable maintenance and replication of the PanCareFollowUp intervention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Managing benthic ecosystems in relation to physical forcing and environmental constraints' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

MaBenE aims at developing a modular, coupled physical-biological model describing the dynamics and biodiversity of estuarine and coastal systems characterised by large (cultivated) populations of shellfish. Based on extensive field studies of physical-biological coupling, as well as on comprehensive system descriptions (for Limfjorden, Oosterschelde, Ria de Vigo) it will develop new model descriptions for the relation between physics, biogeochemistry and biodiversity as a function of forcing by physical conditions, management of the shellfish populations and external human pressure from eutrophication. The model will be flexible in structure. It will be tested in small-scale applications against the field measurements, and applied to whole-system simulations at the three study sites to demonstrate its use in management to relevant stakeholders.