RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploring Ephemeral Feminisms on Portuguese Instagram'.

assistant: **Innovation**

Social media platforms, like Instagram, allow for a wide range of people – including those outside traditional activist circles – to create or engage with feminist content within quotidian social media practices, with political content co-existing with personal, mundane, or aesthetically-oriented content. This project will explore how online feminist practices take shape in increasingly popular yet under-researched practices of ephemeral social media by focusing on Instagram Stories, exploring the new dynamics these carry. This project explores the under-studied local context of Portugal. Portugal is experiencing a moment of political polarisation, which is reflected in its social media landscape. Feminist and political discourses are common on Instagram yet often met with backlash from conservative or right-wing voices. This is a rich and novel site for the analysis of these dynamics, revealing local particularities that are absent from Anglo-Saxon contexts. This project addresses three research objectives: analyse how feminisms are expressed through ephemeral social media affordances; explore what conventions and concerns underly the creation of feminist content; and examine how audiences engage with feminisms on Instagram. This project proposes an innovative ethics-driven, multi-methodological approach. It combines qualitative strategies with the use of digital tools for an exploratory analysis of feminist Instagram Stories; in-depth interviews with feminist content-creators; and focus groups with social media users who engage with feminist content on Instagram.


**Keywords:** Instagram; online feminism; ephemeral media; Portugal; multi-methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real-time endoscopic diagnosis and therapy of gastrointestinal tumors through multimode nonlinear fibers' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

MULTIPROBE introduces a revolutionary photonic technology that represents a significant advancement in the field of optical diagnostics and therapy. Our approach is based on cutting-edge research into pulse propagation within nonlinear complex structures. We are developing an endoscopic device that seamlessly combines optical biopsy and cold atmospheric plasma treatment. This dual-functionality device harnesses the spatiotemporal control of powerful light in multimode fibers, which were previously overlooked due to concerns about excessive light destructuring. We leverage the remarkable progress in the development of the latest optical fibers and in the precise control of light within multimode guides, enabling us to harness the power of plasma, the fourth state of matter. Initially, our focus is on gastrointestinal (GI) endoscopy, but our ultimate goal is to extend this technology areas of medical diagnostics where there is a pressing need for reliable tools for “optical biopsy” and “instant pathology”. These are crucial for real-time diagnosis but have not yet reached the level of trustworthiness required for widespread use. Endoscopy is a vital tool for diagnosing and treating GI disorders, offering a safe and effective approach. However, the current standard of care relies on histopathology for conclusive cancer diagnosis. This leads to significant delays in initiating treatment and incurs high costs. Our project is set to transform this landscape by bringing to life the long-anticipated concept of real-time, in-vivo optical diagnostics often referred to as “optical biopsy”. Our groundbreaking approach seamlessly integrates endoscopic capabilities with cold atmospheric plasma therapy, which employs controlled plasma jets to precisely target and eliminate cancer cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Systemic delivery of oncolytic herpes simplex viruses retargeted to cancer-specific receptors. Virus optimization and business planning.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Solid tumors, in particular metastatic ones, represent unmet clinical needs and the second cause of death worldwide. Oncolytic viruses (OVs) kill tumors and spare normal cells. They are a distinct class of novel anti-cancer agents, frequently administered by intratumoral injection. A Holy Grail in the innovation of OVs is the possibility to administer them by systemic, e.g. intravenous injection, so that in the human body OVs search for metastases and scavenge them. The systemic delivery of OVs tackles societal challenges as it meets the needs of metastatic patients, those who die of cancer and need innovative therapies most. The Principal Investigator has generated a family of innovative oncolytic herpesviruses (ReHVs) which specifically target HER2-positive tumors (HER2-ReHVs). In preclinical studies HER2-ReHVs exhibit high specificity for HER2-positive cancers, high anti-tumor efficacy also against metastatic tumors, vaccinate against metastatic-like tumors, and are highly safe. These properties position ReHVs for systemic delivery. The ReHV technology is protected by a portfolio of patents. The objectives of this Proposal are twofold. Firstly, to improve the systemic delivery of ReHVs by identifying the obstacles that constrain such administration, to develop novel strategies to overcome them, including high-risk high-gain modifications that make ReHVs better suited for the systemic delivery. Secondly, to carry out initiatives for the technological transfer, i.e. development and commercialization of ReHVs. These include the detailed planning of activities to take ReHVs to the authorization for a First-in-Human clinical experimentation, to develop a business plan and carry out OV market analysis and search for investors. By combining the Development and commercializa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Telomerase structure and function by fluorescence'.

assistant: **Innovation**

In this proposed project, single molecule Fluorescence Resonance Energy Transfer (FRET) studies on human telomerase, a ribonucleoprotein which polymerises the telomeric ends of eucaryotic chromosomes de novo, will be performed.The investigations will provide insight about telomerase structure, its dynamics and catalytic mechanism. In the first part of the project, the structure and dynamics of the RNA template of human telomerase (hTR) alone and in complex with human telomerase (hTERT) will be explored.In the second part, a methodology to investigate the telomerase mechanism by single molecule spectroscopy will be established. For the structure and dynamics studies, the RNA component of human telomerase will be labeled by hybridisation of fluorescently labeled PNA probes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Widening IST Networking Developmet Support - Latin America'.

assistant: **Innovation**

The WINDS Latin America project aims at deepening strategic RandD cooperation between Europe and Latin America by building, starting from what already exists, a multinational and multistakeholder community that will involve a significant representation of the relevant European and Latin American actors (researchers, policy makers, users) that deal with technology applications. The project will: 1.\tBuild the observation, analysis and forecasting capacity required to identify key RandD issues on which to focus EU-LA cooperation, and key actors that shall be involved in international collaboration in the field;2.\tGuarantee that information on European RandD is promoted, disseminated and transferred to a large number of interested research, policy and practice actors in Latin America, therefore facilitating dialogue among policy makers, companies, civil society and the research community; 3.\tOrganize two research conferences in LA, two policy seminars in Europe and a final Conference to enhance the existing dialogue and cooperation with all Latin American stakeholders, uplifting European RandD relevance;4.\tEstablish a sustainable open consultation process that will lead to a roadmap for future RandD in an Latin America - Europe collaboration perspective5.\tCoordinate with other existing support actions in order to contribute to the building of a global support network (the WINDS global network) able to deepen strategic European cooperation at a global scale.The project will build on two EU successful support and networking projects targeted to Latin America (Eurolatis and @LIS ISN) and will develop in a complementary way with existing EU (i2010, eEurope, etc.) Latin American (eLAC 2007) policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REGULATORY GENE NETWORKS IN SEED COAT DEVELOPMENT' to be submitted under Seventh Framework.

assistant: **Abstract**

Plant seeds are responsible for most of the world’s food supply and are important for the production of biofuels, fibers, and value-added chemicals. Seeds are also complex biological structures made of three genetically different tissues: the embryo, the endosperm that has nourishing functions and the seed coat that interfaces with the environment. The seed coat of the model plant Arabidopsis thaliana can be divided into five structurally different layers. The innermost layer, the endothelium, accumulates proanthocyanidins, strong antioxidant compounds that create a protective chemical and physical barrier, and coordinates seed growth in concert with the endosperm, embryo and other seed coat layers. From an applied perspective, the endothelium is responsible for the important agronomic trait of seed quality and growing evidence suggests that seed proanthocyanidins are beneficial for human health. Therefore, a deeper understanding of the molecular mechanisms underlying seed coat development might have profound scientific and practical implications.I propose a project aimed at elucidating the regulatory gene networks responsible for the development of the endothelium in A. thaliana. In order to achieve this goal, I propose to first dynamically profile the endothelium transcriptome through the INTACT method for individual cell types isolation. Second, I plan to start mapping regulatory gene networks by characterizing the downstream target genes of the TRANSPARENT TESTA 16 (TT16) transcription factor, known to play a key role in A. thaliana endothelium development. This study will be combined with a complementary analysis of TT16 protein complexes. Finally, the data obtained by each of the three project steps will be cross-analyzed in order to gain a broader understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Doing It Together science (DITOs)' (DITOs) under Horizon 2020.

assistant: **Objectives**

Our project, 'Doing-It-Together Science', DITOs, represents a step change in European public engagement with science and innovation. We propose moving from a model in which scientific research, innovation, and problem-solving is mainly driven by scientific/professional institutions to one based on active public participation and capacity building with various levels and strategies of engagement in the scientific process.  At the core of our ethos is a recognition of people's existing expertise and the different ways people want to and do engage in science and technology. The project is aimed at elevating public engagement with science across Europe from passive engagement with the process of developing science to an active one. Citizen Science and Do It Yourself (DIY) scientific efforts demonstrate that this is possible, and our aim is to ensure that the European Research Area will become leader in ‘deep’ public engagement that is afforded by these advances.As a 'Coordination and Support Action', this project will support and build upon DIY, grassroots, and frugal innovation initiatives so that in the short and medium term we sustain localised capacity building and in the long term the effects of these grassroots efforts channel to policy makers at different levels, from external advice to societal inputs, regarding appropriate research and innovation policies.The proposal includes the participation of policy bodies (European Citizen Science Association, DE), SMEs (Tekiu, UK; Eutema, AT), Universities (University College London, UK; Universite Paris Descartes, FR; University of Genève, CH), Science galleries and public spaces (Royal Belgian Institute of Natural Sciences, BE; Medialab-Prado, E; Kersnikova Institution, SL) and NGOs (Meritum Association, PL; Waag Society,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'First centralized data platform for efficient and collaborative development of offshore energy projects' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Offshore project design, planning and maintenance are complex tasks involving a multitude of companies and domain experts. The industry is lacking the ability to share information across the ecosystem of companies. This status quo substantially delays project timelines and prevent for risks to be uncovered. In an industry characterized by high capital cost, streamlined execution and avoided risk enable millions in savings.FieldTwin is a digital working environment for planning, installing, operating and abandoning energy fields. Assets are integrated with external data sources and smart analytic tools creating smart digital fields. Collaboration occurs in a visual relevant context (as it will in real-world), in real-time and based on real data. The benefits are a lower risk of communications and planning errors; 30% to 70% reduced cost in the design process for the whole value chain by quickly finding the best solution and accelerated timelines across the life of a project, 20-80% lead time reduction in planning and design phases and total project lead time reduction or 10-30%.With FieldTwin we are first to market. FieldTwin is commercialised as a PaaS model. We already have over 100 beta user-licenses, counting with big corporations amongst our clients. We estimate selling 11k licensees by 2022, generating €26.4M. The feasibility study will serve as the basis to finalize our product development strategy and commercial and financial plan.FutureON AS emerges from Xvision AS - with more than 15 years’ experience as provider of visual engineering solutions for clients worldwide in the offshore domain. Our core team and co-founders are all experienced entrepreneurs and senior professionals within visual design, software development and offshore domain experts. Our mission i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'String Cosmology and Observational Signatures' to be submitted under Seventh Framework.

assistant: **Abstract**

The big bang and its immediate aftermath remain one of the great mysteries in science, and it is likely that only an inter-disciplinary approach using both fundamental particle physics and cosmology will get us closer to understanding the origin of our universe. Currently the most promising framework for a theory of all particles and forces is string theory; however, it has been notoriously difficult to address cosmological issues within the theory. Only in the last few years has it been possible to construct  stringy  inflationary models as well as radically new string-inspired models, such as the cyclic universe.This research project proposes to explore string cosmology by focusing on the characteristic elements of string theoretic models: string dynamics (typically leading to non-canonical kinetic terms and many relevant light fields), brane dynamics (inter-brane forces, their motion, collision and eventual stabilization), holographic approaches (in particular attempts at understanding the big bang using the AdS/CFT correspondence), violations of the null energy condition (ubiquitous in string cosmology, but not much explored to date) and intersecting brane constructions.These characteristic elements are equally relevant for both inflation and the cyclic universe, and they will therefore be used to identify distinct observational signatures of the string theoretic cosmological models, for example with regard to gravitational waves or the statistics of primordial temperature fluctuations in the cosmic radiation left over from the big bang. Combined with the upcoming precision cosmological data from ground and satellite experiments, this research has the potential to significantly enhance our knowledge of both fundamental theory and cosmology and, therefore, to shed li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Influence of Streptococcal virulence factors on host autophagy regulation' (GASAUTOPHAGY), addressing dissemination and exploitation.

assistant: **Impact**

Group AStreptococcus (GAS) is a predominant Gram-positive bacterium causing a substantial burden of diseases in humans. Autophagy is a starvation-induced response that provides nutrients by degrading long-living proteins and recycling intracellular organelles. In 2004, autophagy was identified as a new immune mechanism for killing and clearing invading GAS in epithelial cells. It is regulated by host proteins such as Beclin1, ATG 5, ATG6 and LC3. On the other hand, host proteases such as calpain, caspase and cathepsin inhibit autophagy activation by degrading these proteins.GAS virulence factors that can affect host autophagy have never been identified or described so far. The first part of this proposal will focus on the GAS virulence factors that can initiate degradation of host autophagy proteins. Potential GAS virulence factors listed in this proposal are Streptolysin S (SLS) and Streptolysin O (SLO) which are playing a role in host protease activation. Streptococcal Pyrogenic Exotoxin B (SpeB) and Group A streptococcus protease (SpyCEP) are also going to be investigated for their potential to directly degrade host autophagy proteins. Degradation of host proteins involved in autophagy, by these proteases can influence autophagy regulation. The second part of this proposal is aiming to study the role of autophagy in zoonotic streptococci infection. As increasing numbers of invasive infection caused by zoonotic streptococci are recently reported, this would be a first and an important study. The third part will be to study the role of autophagy in bacterial killing in neutrophils. Neutrophils are known to be one of the most important immune cells to clear GAS infection. However the role of autophagy in neutrophils against GAS infection has never been studied. The unde