RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative Methods for wave energy Pathways Acceleration through novel Criteria and Test rigs' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

IMPACT is a collaborative research and innovation project which aims to develop and demonstrate a next-generation testing approach for Wave Energy Converters (WECs). The proposed 250kW Dual Hardware-In-the-Loop (DHIL) testing platform is based on a technology which expands the capabilities of the already established Hardware-In-the-Loop technique. The DHIL platform combines together:•one rig for testing the entire drivetrain either linear or rotary, from input mechanical to grid compliant power;•one rig for testing structural components and mooring lines, either in dry or wet environment.The DHIL platform is therefore expected to test subsystems impacting on the 75% of the Levelized Cost Of Electricity (LCOE) of a wave energy converter.The novel methodologies proposed by the IMPACT project reduce the test duration by 50% with respect to a typical endurance test and focus on key aspects such as reliability, performance and survivability. Clear quantitative, test-derived metrics will be produced to characterize these aspects, including also techno-economic and environmental impact assessment of WECs. A test campaign involving subsystems of different device types will be undertaken during the IMPACT project to demonstrate the DHIL testing platform capabilities. A Technical Advisory Board made up of WEC developers will directly benefit of the campaign results and will provide external guidance for making the DHIL testing platform a suitable product for the international market.At the end of the project a novel platform for all the wave energy converter types will be delivered, contributing to a drastic acceleration in their progress through laboratory tests and leading to a rapid advancement from TRL 3 to TRL 5.A publicly released deliverable will describe the project resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced T-cell Engineered for Cancer Therapy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

T-cell engineering strategies for Cancer therapy, either Chimeric Antigen Receptors (CARs) or TCR transfer holds promise to revolutionize cancer treatment. There are, however, considerable barriers to be overcome to take this form of therapy to a format that can benefit all EU citizens with a wide range of common cancers. The aim of this consortium is to exploit advances in T-cell engineering to allow the full potential of CAR therapy to be unleashed.At present, CAR therapy requires a bespoke autologous therapeutic product for each patient. This greatly limits practicality, scalability and commercialisation. The development of a strategy for creation of universal engineered T-cells is the first key aim of this consortium. There is an increased appreciation of the immunological hostilities (CAR) T-cells face in the tumour microenvironment, and prevention of this local immune suppressive effect will likely be critical in permitting effective tumour control. The second main aim of this proposal is therefore to engineer CAR T-cells to be resistant to the hostile microenvironment. CAR T-cells can only be effective if they can access the tumour site. Exploiting the fact that neo-angiogenesis is a hallmark of neoplastic progression, the third aim of the consortium is to utilise endothelial cues of neo-angiogenesis to direct CAR T-cell migration and activity.The central technological theme of this consortium is the application of TALEN-mediated gene editing strategies alongside genetic modification with integrating vectors. Using this approach, we will implement a clinical study of “universal” CAR T-cells in refractory lymphoma. Further, this work will be complemented with highly focused development of T-cells which are resistant to hostile microenvironments and which can home
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intelligent Environment for Diagnostics, Treatment and Prevention of Eating Disorders' (SALUT).

assistant: **Concept**

SALUT will leverage advances in information and telecommunications technology to design, prototype and trial innovative tools and cost effective treatment strategies for the prevention and treatment of eating disorders.Technology and scientific partners will jointly develop new therapeutic models combining web-based applications; emerging wireless telecommunications protocols; and cost effective therapeutic strategies being developed by scientific partners. The project will also exploit established industry standards to implement a networking infrastructure for a research and prevention network. This network will act to facilitate information exchanges between researchers, practitioners and the general public. It will also be a direct channel for the dissemination of project results.SALUT takes a holistic approach in addressing uptake and innovation during all key phases of the prevention, diagnostic and treatment cycle. While the project targets only specific areas within each phase, we expect the tools and other project results to serve as building blocks for a new patient environment that exploits fully the benefits offered by new and emerging technologies.The overriding objective for SALUT is to support a prevention and treatment environment where the patient is given a greater sense of comfort, flexibility, privacy, greater choice in establishing communications, recording progress, and making decisions.Specifically, the project will:Develop natural language question answering systems to give information about eating disorders.Develop expert systems to improve the flexibility and availability of diagnostic tools and services.Design new cost effective treatment strategies by using web based or emerging wireless and 3G protocols.Deploy regional research and prevention
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Abnormal Motherhoods: Precariousness, Sterility and Anciery in 20th and 21st Century Spanish Cinema' (MOTHERING), addressing dissemination and exploitation.

assistant: **Impact**

Many depictions of motherhood in 20th-century European media fall under what Susan Maushart described as the mask of motherhood (3). With this expression, she refers to narratives that envision motherhood as healthy and unproblematic. However, since the last decade of the 20th century, this situation has changed, where maternity has become a controversial subject, and discussions over issues such as ambivalence towards the child, sterility, and maternal stress are conspicuous in different media. This is where the planned project, which regards motherhood as a central question in gender studies, picks up. Despite this increased visibility, many maternal experiences do not fall under the category of normal in normative societal discourses, and mothers affected by them are portrayed as ill or unfit. Abnormal motherhood encompasses practices that lie outside ... the limits of a norm previously established by hegemonic thinking; and, vice versa, normality is what remains after establishing the edges of the abnormality (Huertas 26). Taking Spain as the main case of study, I analyze 20th and 21st-century films of mother-child relationships deemed abnormal and sick, characterized by sterility, poverty, and anxiety, in contrast to normal motherhood, imagined as fertile, healthy, and unproblematic.


**Keywords:** Motherhood, normative, Spain, sickness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a Compact Transportable Instrument for the Measurement of Tropospheric 0H and H02 on remote and Airborne Platforms' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

To develop a compact instrument that can measure the concentrations for OH and HO2 radicals from remote platforms at ground and from aircraft. Hydroxyl- (OH) radicals are the most important oxidants in the troposphere, because they control the chemical  transformation of most gases released into the atmosphere. Many reactions of atmospheric compounds with OH  form hydroperoxy- (H02) radicals which react with O3 and NO to recycle OH. This HOx cycling is a key  process in the photochemistry of the troposphere, because it increases the oxidation efficiency of OH and  controls the rate of formation of photooxidants (O3, H2O2, PAN, etc.) in the polluted troposphere. Thus, a  thorough understanding of the chemistry of the HOx family is crucial to assess possible changes in the  self-cleansing efficiency of the atmosphere and to understand the photochemical ozone formation in both the  planetary boundary layer and in the free troposphere. Measurements of OH and HO2 are indispensable to test  the existing atmospheric chemistry models; however reliable data are scarce and have only been measured from  locations at ground.  The instrument will be based on the laser induced fluorescence (LIF) technique which has been developed  successfully in a previous EC project (Hofzumahaus and Webb, 1995) for the detection of tropospheric OH.  The specific tasks of the project aim:  1. to expand the measurement capabilities of the OH LIF technique by the development of a measurement channel for HO2 radicals, in order to allow the true simultaneous measurement of OH, HO2, and of the ratio of OH/HO2.  2. to develop a compact laser system which can be operated on board on airplane and to downsize the whole LIF instrument into a compact automatisated package.  3. to improve the LIF detection sens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design for changing values: a theory of value change in sociotechnical systems' (ValueChange) targeting Horizon 2020.

assistant: **Abstract**

One of the key insights from the philosophy of technology is that technological artifacts and sociotechnical systems are not value neutral but supports or inhibits certain values. Several philosophical accounts for understanding the embedding of values in technological artifacts have been proposed and approaches like Value Sensitive Design, Design for Values and Responsible Research and Innovation have been established for integrating values into technical design. A blind spot is, however, the possibility of value change after a sociotechnical system has been designed. For example, when many of our current energy and transportation systems were designed sustainability was not yet a central value, and we are now struggling to incorporate this value into these systems. Progress in the field is currently inhibited by the lack of a philosophical theory of value change in sociotechnical systems. This proposal fills this gap by developing such a theory. It moves beyond the start of the art by proposing a dynamic rather than a static account of values, by developing insights in the dynamics of value change, by extending analysis about the embedding of values in technical artifacts to sociotechnical systems and by developing design strategies that aim at designing sociotechnical systems that can better deal with value change. The proposal has the following more specific objectives: 1) to propose a notion of value that is applicable to sociotechnical systems and that can account for value change, 2) to develop a taxonomy and mechanisms of value change in sociotechnical systems, 3) to extend philosophical analyses of the embedding of values in technological artifacts to sociotechnical systems 4) to carry out empirical studies about value change in energy systems and robot systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modifying gravity with large or infinite extra dimensions: understanding foundations and phenomenology' in the context of a Sixth Framework call.

assistant: **Objectives**

This project is devoted to understanding gravitational physics, and is motivated by both theory and experiment. From experiment, we have supernova data that suggests we should modify gravity in the infra-red. This is difficult to do without introducing problems such as ghosts, vDVZ discontinuities and strong coupling. We intend to develop models and check their consistency. Specifically, we propose to develop the phenomenology of the asymmetric brane model, extending previous results to include non-trivial Gauss-Bonnet coupling in the extra dimension. We also intend to examine the impact of asymmetry on the strong coupling problem in DGP gravity, as well as the issue of instabilities on self accelerating branes. An asymmetric generalisation of the GRS model will also be studied. From theory, we have strings. These represent our best candidate for a quantum theory of gravity. Since strings live in 10 dimensions, it is vital we understand gravity in more than 4 dimensions. To this end, we will study branes of higher co-dimension. We will identify key patterns in the structure of junction conditions, and hope to find non-trivial solutions, in particular cosmological ones that could model our universe. We will also study higher dimensional black holes . Black holes gravitate so strongly they lie at the interface of classical and quantum" gravity. We will investigate the stability of the black ring in five dimensional General Relativity. We will also attempt to find any non-trivial extensions to Lovelock gravities, aswell as an exact black string solution in Gauss-Bonnet gravity. The area formula for the entropy of black holes suggests that gravity is "holographic" in nature. We will investigate this from a braneworld perspective. We will study braneworld holography in a bla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Wood formation processes : the key to improvement of the raw material' in the context of a Fourth Framework call.

assistant: **Objectives**

The proposal addresses section 1.3 'The Forestry-Wood Chain'. It aims to 'enhance the fibrous and mechanical properties of wood' (1.3.1.2) by improving control over wood properties, enabling them to be matched to enduser requirements. It will contribute to improved productivity of an increasingly important species (poplar) for the European pulp and paper industry ( 1.3 .1.1), and to improved forest management and harvesting systems by providing a basis for genetic transformation of trees to ensure efficient use of forest land (1.3.1.3). This will lead to increased competitiveness and economic benefits for European tree growers and industrial users. Hybrid aspen ( Populus tremula x tremuloïdes) will be used as a model system to obtain a better understanding of fundamental wood formation processes.This represents an innovative approach to the study of plant cell differentiation, which has hitherto largely concentrated on non-woody species. It will establish generic principles for use in genetic engineering of other tree species and provide a base for a programme of genetic modification to produce 'designer' trees, with wood matched to end-users' specific requirements. The work is timely because there is increasing demand for uniform raw material of high quality from the wood processing industries, coupled with a decrease in supply from natural forests. There is also pressure on the forest industry to grow native hardwoods rather than exotic softwoods, since the latter are now regarded as aesthetically unattractive and environmentally damaging. Improving the productivity, uniformity and quality of hardwoods will reduce processing costs and wastage for industrial users, in particular, it will reduce energy requirements, and by increased utilisation of raw material will redu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gene network rewiring by an engineered CRIPSR-Cas12a variant' (GNRECC).

assistant: **Innovation**

In the last 10 years, an increasing number of studies employed -omics technologies to describe the molecular changes underpinning cellular functions. However, a large part of these findings is awaiting an experimental validation. This is due to the lack of efficient molecular tools able to control both multiple and distinct genetic interactions.  Recently, I described a new CRISPR/12-based genome engineering tool that, for the first time, it provides the constitutive, conditional, inducible, orthogonal and multiplexed engineering of dozens of endogenous genes, simultaneously. In this research proposal, I aim to increase the efficiency of this platform in the context of multiplexed genome engineering applications, such as gene network rewiring. To this aim, I will use techniques inspired by the statistical physics of complex disordered systems, to design a more potent version of my CRISPR/Cas12-based genome engineering tool and, I will use this novel platform to rewire signaling pathways involved in cellular proliferation. This research proposal is structured into the following tasks: rational design of novel Cas12a variants, validation of novel Cas12a variants, gene network rewiring by a novel Cas12a variant.  By coupling statistical physics to both protein and genome engineering this project will pave the way for efficient and large-scale engineering of gene networks.


**Keywords:** CRISPR-Cas12
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gene overdosage and comorbidities during the early lifetime in Down Syndrome', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of the project is to elucidate etiological mechanisms involved in the appearance of obesity, and intellectual disability comorbidities in Down syndrome (DS). With its incidence of 1 in 1000 births, DS offers a great opportunity to uncover common/novel mechanisms because it is associated with a higher risk to develop several obesity, and intellectual disability. The increased risk to develop this combination of comorbidities in DS, suggests that specific genetic or epigenetic mechanisms associated with trisomy 21 (the cause of DS) predispose to this comorbidity.For this aim, GO-DS21 will have the following objectives: 1) To determine age-related comorbidity patterns observed over the early lifetime (before age 45) in persons with Down syndrome (WP1). 2) To identify specific physiological biomarkers (WP4), and regulatory and epigenetic signatures (WP5) in human, cellular and animal models. 3) To decipher the contribution of environmental factors (stress, diet, exercise) to trisomy 21 obesity/ID comorbidities in preclinical models (WP2, 3). 4) To investigate the effects of overdosage of three Hsa21 candidate genes (DYRK1A, MRAP, NRIP1) to explain comorbid patterns in mouse models (WP3). 5) To integrate multilevel data from human patients, preclinical and cellular models across different spatial and temporal scales of biological complexity using computational biology models and machine learning approaches (WP6). 6) To design new therapeutic interventions to reduce the penetrance of comorbidities in preclinical models (WP3 and WP4). This approach will help to improve diagnosis and understanding of prognostic factors, and will establish recommendations and targeted interventions to prevent or minimise comorbidities in persons with DS (WP7). Beyond the impact for patie