RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CD22/CD19 dual redirection Dual targeting of CD22 and CD19 with BiTE-secreting and CAR-expressing bispecific T-cells for adoptive Cellular ImmunoTherapy in advanced B-cell Acute Lymphoblastic Leukemia' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Anti-CD19 immunotherapies based on Bi-specific T-cell Engagers (BiTE) or chimeric antigen receptor (CAR)-expressing T-cells have revolutionized the treatment of refractory/relapse (R/R) B-cell acute lymphoblastic leukemia (B-ALL). However, despite initial impressive complete response (CR) rates, many patients relapse few months after anti-CD19 immunotherapy; in many cases with CD19 antigen loss. Such relapses are devastating, and patients are left with virtually no further treatment options. Dual targeting of the pan-B antigens CD19 and CD22 has been proposed as a therapeutic strategy to distribute the antigenic pressure over two molecules and to reduce immune escape by covering practically all B-ALL blast subclones. CD19/CD22-directed dual CARs have in fact been proposed to overcome B-ALL immunoediting during CAR T-cell therapy but, unfortunately CD19/CD22 dual CAR-treated R/R B-ALL patients showed CR rates not sustained over time and relapse with limited CAR T-cell expansion. In contrast to CAR T-cells, BiTEs-secreting T-cells represent a unique strategy capable of redirecting bystander T-cells to tumor cells because T-cell-produced BiTEs will be continuously secreted and will decorate, through the CD3scFv, the cell surface of practically all circulating and ex vivo manufactured bystander T-cells. Our overarching goal is to provide a novel and innovative T-cell redirecting immunotherapy for the treatment of R/R B-ALL by dual targeting both CD22 and CD19 with T-cells modified to simultaneously secrete CD22xCD3 BiTEs and express CD19 CAR (referred to BiTECAR). This strategy harnesses the biological advantages of both CARs and BiTEs while minimizing their limitations and will circumvent the potential low transduction efficiencies of the BiTECAR construct because the CD22
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Rapid and accurate manufacturing of moulds and dies - using pre-hardened materials and innovative hexapod machine tools'.

assistant: **Objectives**

The Technical Objective of this proposed RTD is to develop new rapid and highly accurate technologies for the manufacture of hardened steel tooling for the SME based tooling industry. There are more than 1O,OOO mould and die manufacturers in Europe of which at least 90% are SMEs. These small enterprises are encountering increasing compebbon particularly from pacific Rim countries such as Japan, Taiwan and China. To adapt to these pressures the European Mould and Die Sector has in recent years seen a growth in the use of electronic data transfer, computer assisted modelling and rapid prototyping techniques. The manufacture of hardened steel product on tooling has also improved with the introduction of CNC machining technology and enhanced cuffing tools and tool coatings However, the basic manufacturing methodology used by these companies has not changed significantly and during the production of hardened steel tooling one will typically find: -Machining on limited 3 or 4 axis machinery Multiple machine setups The utilisation of relatively low speeds and feeds Poor cutter orientation to the workpiece Complex process sequencing Inter process hardening (often on a subcontract basis) Extensive hand finishing and polishing of surfaces. Considerable scope exists to improve manufacturing performance by the introduction of novel machine and processing methodology. Promising areas of research include the evolution of a new generation of high speed. multi axis contouring machines with 5 or more axis of motion including revolutionary parallel linked  traditional machines. Further benefits can also be achieved by machining dies from pre hardened materials using state of the art tooling and extreme high speed cuffing conditions. The Industrial objectives of the proposed project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Autonomous Robotics for Transcatheter dEliveRy sYstems' under Horizon 2020.

assistant: **Concept**

Cardiovascular diseases are the single most common cause of death in Europe and worldwide. Minimally invasive catheter-based approaches gain in importance as they extend treatment to patients with high peri-operative risks. Today, catheter-based treatment comes with steep learning curves, poor ergonomics and exposure to damaging radiation. The ARTERY project offers a radiation-free approach based on shared-autonomy robotic catheters, with increased user engagement and easy interaction. Echocardiography, optical and electromagnetic sensing techniques provide a superior view upon the cardiovascular space. Fluidic actuation paired with artificial intelligence form the motors of the next generation of robotic catheters that autonomously find their way towards the target site. The interventionist is fully immersed in the surgical field. Key landmarks automatically highlighted in the holographic display give the impression of being teleported right inside the patient’s anatomy. Variable-autonomy schemes allow the interventionist to take over control at any instant. Artificial intelligence algorithms turn catheter navigation to a simple task as the autonomous catheters maneuver their distal portion to align to where the interventionist points his/her finger. ARTERY showcases this new paradigm on mitral valve repair and left appendage closure, two complex yet critical life-saving interventions. Clinicians and company partners are ready to take over the technology developed in ARTERY and translate it to the clinic right after the project.


**Keywords:** Artificial Intelligence, Shared Autonomy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving DSP software documentation process to promote reuse' (DSP-ACTION).

assistant: **Innovation**

The role of digital signal processing (DSP) is increasingly important in modern electronic devices.As the amount of software constantly increases, and the product development times shorten, there are needs for software process improvement. Since the product development is often evolutionary, the best way to improve is to learn from the experience and re-use it at many levels.The objective of this experiment is to improve DSP software documentation to increase reuse of design documents, and decrease effort required to make and review documents by 50%.THE EXPERIMENTTo achieve the objective, the approaches of Experience Factory and GQM are used.The experiment consists of following activities:a) Selection and adaptation of new documentation tools for DSP algorithm and software development, compatible with version and configuration management system PCMSb) Definition and implementation of GQM metrics for DSP documentation process follow-up c) Training DSP designers on the improved documentation methods d) Piloting the new methods and collect feedback by GQM metrics, and qualitative assessment.The baseline application is DSP software development for a mobile telephone product.Nokia Mobile Phones R&D-Oulu employs about 420 people, 30 of them are involved in this PIE.EXPECTED IMPACT AND EXPERIENCENMP expects to decrease field failure rates and total costs, increase productivity, and have more satisfied customers. Technically NMP expects to ease the introduction of new features, have better quality of re-used source code along with increased reusability of design documents.Upon successful completion of the PIE the results will be replicated in other NMP sites and lessons learnt disseminated for wider community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clean Refinery Hydrogen for Europe' to be submitted under Horizon 2020.

assistant: **Abstract**

The REFHYNE project will install and operate a 10MW electrolyser from ITM Power at a large refinery in Rhineland, Germany, which is operated by Shell Deutschland Oils.  The electrolyser will provide bulk quantities of hydrogen to the refinery’s hydrogen pipeline system (currently supplied by two steam methane reformers). The electrolyser will be operated in a highly responsive mode, helping to balance the refinery’s internal electricity grid and also selling Primary Control Reserve service to the German Transmission System Operators.The combination of hydrogen sales to the refinery and balancing payments create a business case which justifies this installation. This business case will be evaluated in detail, in a 2 year campaign of techno-economic and environmental analysis. The REFHYNE business model is replicable in markets with a similar regulatory structure to Germany. However, to expand this market to a GW scale, new business models will be needed. These will include valuing green hydrogen as an input to industrial processes (to meet carbon policy targets) and also on sales to H2 mobility markets. The REFHYNE project will gather real world data on these models and will use this to simulate the bulk electrolyser model in a range of market conditions. This will be used to produce reports on the conditions under which the electrolyser business models become viable, in order to provide the evidence base required to justify changes in existing policies. A campaign of targeted dissemination will ensure the results of these studies reach decision makers in large industrial sites, financiers, utilities and policy makers.The REFHYNE electrolyser will be the largest in the world and has been designed as the building block for future electrolysers up to 100MW and beyond. REFH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Operational modelling for coastal zone management' (OPCOM) targeting Fourth Framework.

assistant: **Abstract**

In this project methods and techniques for continuous monitoring and operational forecasting for coastal waters shall be improved based upon existing operational circulation and dispersion model systems. OPCOM will address open questions concerning the usability of results from such models for the most relevant fields of medium to long-term coastal zone management in close cooperation with first and potential end-users. This will lead to the optimization of efforts to enhance forecast quality. In particular, it is envisaged to join deterministic and stochastic forecasting methods and techniques to improve the predictive capability of traditional models. Additional goals of the investigations will be to derive general criteria for the design of operational model systems to improve integrated coastal management. An additional important outcome of the project will be the development of a coastal management database structure incorporating essential information derived from (pre-) operational model systems and monitoring networks suitable for GOOS purposes. In this context it is envisaged to use experiences of the project partners from existing currently running operational model systems of coastal zones (e.g. Elbe estuary) or pre-operational models (e.g. Bay of Marennes-Oleron). No basic model development is envisaged but available and continuously produced model results shall be analyzed for coastal zone management purposes. These model systems shall be modified during the project duration taking into account specific local demands for coastal management by possible first and possible end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Next generation of AI-powered robotics for agile production'.

assistant: **Concept**

AGIMUS aims to deliver an open-source breakthrough innovation in AI-powered agile production, introducing solutions that push the limits of perception, planning, and control in robotics, enabling general-purpose robots to be quick to set-up, autonomous and to easily adapt to changes in the manufacturing process. To achieve such agile production, AGIMUS leverages on cutting-edge technologies and goes beyond the state-of-the-art to equip current mobile manipulators with a combination of (i) an advanced task and motion planner that can learn from online available video demonstrations; (ii) optimal control policies obtained from advances in reinforcement learning based on efficient differentiable physics simulations of the manufacturing process; as well as (iii) advanced perception algorithms able to handle objects and situations unseen during initial training. Along the way, optimization of energy efficiency and the use of 5G technology will support further pushing the limits of autonomy. The AGIMUS solutions and their impact will be demonstrated and thoroughly stress-tested in 3 testing zones, as well as 3 industrial pilots in Europe, under numerous diverse real-world case studies and scenarios (different tools, environments, processes, etc.). In every step, and from the very beginning, AGIMUS will go beyond current norms and involve a wide range of stakeholders, starting from the production line itself, to identify the essential ethical-by-design principles and guidelines that can maximise acceptance and impact.


**Keywords:** Agile production, versatile robotics, perception and learning, task and motion planning, object manipulation, reinforcement learning, computer vision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel flavour analysis strategies for development of consumer-preferred foods' under Fifth Framework.

assistant: **Concept**

Flavour is the major driver for consumers in the choice of their foods, and Unilever bas designated flavour research, situated in the corporate laboratory in Vlaardingen, as strategic focus to generate competitive advantage. Despite the importance of the parameters, taste and aroma optimisation still largely remains a matter of trial and error. There currently is a strong demand for a more conceptual approach for developing improved-taste products, a strategy preferably guided by a thorough knowledge of the relations between consumer liking, sensory characteristics and the actual molecular composition of the food, in particular of the compounds affecting taste and aroma.A major obstacle here is the analysis of the aroma compounds and especially the isolation of these volatiles. Simple methods allowing fast analyses usually deliver incomplete isolates and artefacts, whereas more sophisticated extraction and high-vacuum distillation techniques are rime- and effort consuming and do not allow high throughput. The fellowship proposal aims at developing and applying new flavour.Analysis techniques combining accuracy with speed, e.g. by miniaturising the isolation and hyphenation with the actual chromatographic analysis. Novel techniques as sorption-based enrichment, fast GC and comprehensive chromatography, with which the applicants have extensive experience, will be of key importance in the project. The research work will be carried out within an existing collaboration project of Unilever Research Vlaardingen, the Free University Amsterdam (Dr. Vreuls/Prof. Brinkman, sample preparation and separation) and the University of Amsterdam (Prof. Schoenmakers, comprehensive separations).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biopolus Aero Green - Feasibility Study' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The objective of the innovation project is to bring to market a high-yield, highly automated aeroponic plant cultivation system suitable for resource efficient, high quality vegetable and fruit production in a limited physical footprint. This core technology and the associated supporting services are expected to be enablers of the widespread appearance of urban farms.The system lessens agricultural land use. Moving production closer to the place of consumption enables reduction in transportation needs, emissions and food waste production. The aeroponic technology produces very high yields while using the fraction of water. The system has the following main economic benefits for the users:• year-round crop production• no weather-related crop failures• no use of pesticides, herbicides• use of 75-95 % less water than the same productive  technologies• greatly reduced food-miles• higher food security and safety• high yield in crop productionUser needs met by the system: demand for products with trustworthy proof of socially and environmentally responsible business practices, demand for chemical-free food products.Targeted users are those SMEs and farmers who produce indoor, and those restaurants and supermarkets where day-to-day fresh fruits and vegetables are important.Economic benefits and ecological impact are the main appeals of the technology. The feasibility assessment’s goal is to quantify these advantages which are major milestones toward successful commercialization.Phase 2 plans are a first demonstration facility and building out full capacity of manufacturing.European dimension: Flagship sustainable biological technologies like Biopolus Aero Green system can help the EU secure its leading position to address ecological challenges and achieve economic growth.Globa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'LIterature For Empowerment against manipulation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

LIFE examines if and how literary reading can be used to help raise awareness of disempowering manipulative influences exerted by one’s environment and the media and foster empowerment to mitigate their effects. It will develop a new cross-disciplinary tool to measure literature’s potential effects on manipulation perception and on the sense of empowerment. It will provide an ‘empowerment canon’ of expert-selected and empirically validated literary texts that can be particularly helpful in this task. The tool will draw from the disciplines of literary studies, psychology, sociology, and communication and will be empirically tested and validated in two diverse countries: Italy and the United States. The media and the environment can exert disempowering influences on one’s life. Indeed, the news, advertising, gaming and social media industries often propel insecurity, social division, consumerism and addictive behaviours, while one’s immediate environment may imbed limiting beliefs and conformism. While the empirical study of literature has been able to show some of literature’s prosocial effects, its potential impact on kindling the sense of empowerment is yet to be determined. LIFE tackles this challenge by researching how literature can help raise awareness of such disempowering manipulative influences and foster empowerment. LIFE will advance the emergent interdisciplinary research area of the empirical study of literature.


**Keywords:** Empirical study of literature, effects of reading, empowerment, manipulation, reading