RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MADness, Religiosity and Environment: belief and materiality in community responses to mental difference and distress among early modern SEAfarers.' (MADSEA).

assistant: **Innovation**

Madness is not only shaped by clinicians within the walls of asylums and psychiatric hospitals, but by ordinary people within communities. The non-material and material aspects of their lives, from belief and religiosity to physical environment, have driven individual and collective understanding, experiences and responses to mental difference and distress throughout history. Through shared cultures and experience, these community contexts can extend across the national and political boundaries which have dominated studies in the history of madness and psychiatry. MADSEA's primary objective is to develop an interdisciplinary methodology for the study of madness in these transnational community contexts, inclusive of the complex interaction of belief (religiosity) and materiality (environment) in the lives of ordinary sufferers. It uses early modern seafarers as a spatial, socio-cultural frame for its investigation, as their shared mobility and exposure to the dynamic effects of the ocean transcended borders and left a rich historical record of the action of religiosity and environment in their lives. Employing a microhistorical approach, MADSEA undertakes an in-depth comparative archival study of the meaning and societal impact of madness in the records of the eighteenth-century Danish-Norwegian and British navies. Blending qualitative and quantitative methods, it achieves three further objectives: establish how seafaring communities understood madness; gauge the degree mental difference and distress were stigmatised or tolerated; and evidence a trans-European seafaring community culture and response towards madness, to demonstrate how religiosity and environment, rather than national boundaries, shape mental illness. As such, MADSEA provides researchers with an empiric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Next-generation flow diagnostics for control' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Fast-paced advancements of hardware and machine-learning algorithms have triggered successful applications of active flow control, even though mainly limited to laboratory-scale applications. One of the main limits resides in the lesson we are able to learn today from experiments. We can successfully train actuators with probes in a controlled environment to reach a certain goal, e.g. aerodynamic drag minimization or noise reduction; on the other hand, an experimental technique that provides a full description of the flow is not available, thus generalization of the actuation effects to real applications is often prohibitive.The objective of NEXTFLOW is to conceive the next-generation flow-diagnostics aimed to flow control by leveraging the principles of completeness and compactness of the measurements. Completeness implies aiming to pursue a complete flow description, i.e. a time-resolved 3D characterization of velocity and thermodynamic variables. This will be achieved through a technique-integration approach based on data-driven methods. This grounds its basis on the principle that the superposed application of techniques is superior to their separate use. Compactness is pursued by exploring solutions with minimum technological complexity, and on developing new data output formats that are directly aimed at flow control applications. Key enablers for this task are (i) the novel concepts I recently proposed on data-driven techniques integration, (ii) the deep embedding of compressed-sensing methods in the data processing and (iii) the data-driven discovery of simplified governing equations of the dynamics. The next-generation flow diagnostics concept will deeply change experimental fluid mechanics and flow control, allowing bridging the gap between the laboratory expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Laser-engineered Biomimetic Matrices with Embedded Cells' in the context of a Seventh Framework call.

assistant: **Objectives**

Traditional 2D cell culture systems used in biology do not accurately reproduce the 3D structure, function, or physiology of living tissue. Resulting behaviour and responses of cells are substantially different from those observed within natural extracellular matrices (ECM). The early designs of 3D cell-culture matrices focused on their bulk properties, while disregarding individual cell environment. However, recent findings indicate that the role of the ECM extends beyond a simple structural support to regulation of cell and tissue function. So far the mechanisms of this regulation are not fully understood, due to technical limitations of available research tools, diversity of tissues and complexity of cell-matrix interactions.The main goal of this project is to develop a versatile and straightforward method, enabling systematic studies of cell-matrix interactions. 3D CAD matrices will be produced by femtosecond laser-induced polymerization of hydrogels with cells in them. Cell embedment results in a tissue-like intimate cell-matrix contact and appropriate cell densities right from the start.A unique advantage of the LeBMEC is its capability to alter on demand a multitude of individual properties of produced 3D matrices, including: geometry, stiffness, and cell adhesion properties. It allows us systematically reconstruct and identify the key biomimetic properties of the ECM in vitro. The particular focus of this project is on the role of local mechanical properties of produced hydrogel constructs. It is known that, stem cells on soft 2D substrates differentiate into neurons, stiffer substrates induce bone cells, and intermediate ones result in myoblasts. With LeBMEC, a controlled distribution of site-specific stiffness within the same hydrogel matrix can be achieved in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiscale Frameworks for Biosolutions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Multiscale Frameworks for BiosolutionsFrameBio’s goal is to revolutionise biotechnology by developing comprehensive computational modules that simulate microbial behaviour of bioproducts (for food applications, such as Single Cell Proteins)  and quantifying its resource dependencies across various scales: Microorganism Design and Engineering - Fermentation Design of Experiments coupled with High Throughput Screening - Commercial Production Scheme Simulations - Supply Chain Design - Planetary Resource Utilization and its Impact on Earths Geophysical Synergies, to predict the broad sustainability impacts of BioSolutions. This Doctoral Network (DN) will train 13 PhDs in genomics, metabolomics, fermentation and process optimisation, and data science and sustainability assessments in a unique venture.


**Keywords:** Mechanistic Models, Quantitative Sustainability Assessment, Metabolic Engineering, Process Systems Engineering, Fermentation, Computational Fluid Dynamics, Process Simulation, Techno-Economic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring stepping stones towards renewable hydrogen driven fuel cells for mobile applications' under Fifth Framework.

assistant: **Concept**

The challenge for oil companies is to transform their business from refining of crude oil to sustainable production of energy and energy carriers in the 21st century. Future scenarios appoint hydrogen and hydrogen fuel cell powered vehicles as one of the most attractive options for transport. Hydrogen fuel cells are highly efficient without handful emissions; however, numerous technical problems like hydrogen storage, hydrogen supply infrastructure, safety issues, etc. are blocking their introduction into the market. Alternative solutions are to produce hydrogen from hydrogen containing fuels in situ by means of a fuel reforrner.This allows any hydrocarbon fuels to be used, including natural gas, methanol and biofuels (i.e. fuels derived from biomass). The aim of the proposed project focuses on the development of enabling technologies for large-scale introduction of hydrogen fuel cell powered vehicles.Research in the proposal has been divided into three subjects:1) Biomass conversion towards fuel component
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Evaluation of novel recombinant antigens as candidates for a vaccine against schistosomiasis mansoni'.

assistant: **Innovation**

Knowledge of the immune mechanisms elicited in rodents and primates by the attenuated schistosome vaccine will form the basis of efforts to develop a recombinant antigen vaccine against Schist soma mansion. Construction of special cDNA libraries will assist in novel molecular biology approaches to clone and express the relevant membrane/secreted larval antigens. The protective potential of all recombinants will be tested in mice, and the most promising also in baboons. Studies on human populations will identify differences between resistant and susceptible individuals in their responses to the recombinants. The estimation of infection intensity by measurement of circulating antigen levels will be validated in the realistic baboon model, and the interaction of infection with vaccination will also be explored in the baboon providing information vital future human vaccine trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Smart Asset re-Use in Creative Environments'.

assistant: **Concept**

SAUCE will research, develop, pilot and demonstrate a set of professional tools and techniques for making content ‘smarter’, so that it is fully adaptive in a broad, unprecedented manner: adaptive to context (which facilitates re-use), to purpose (among or within industries), to the user (improving the viewing experience), and to the production environment (so that it is ‘future-proof’). The approach is based on research into light-field technology; automated classification and tagging using deep learning and semantic labeling to describe and draw inferences; and the development of tools for automated asset transformation, smart animation, storage and retrieval. These new technologies and tools will show that a vast reduction of costs and increases in efficiency are possible, facilitating the production of more content, of higher quality and creativity, for the benefit of the competitiveness of the European creative industries. Specifically, SAUCE will research and develop:• Methods of generating smart world-views by capturing and processing light-fields, augmenting them with semantics and making them usable for media production pipelines.• A framework and tools for automatically classifying, validating and finding smart assets, using deep learning and semantic labeling techniques on 2D and 3D data.• A framework and tools for the automatic transformation and adaptation of smart assets to new contexts, purposes, users and environments, and for the synthesis of new smart assets from existing ones.• Real-time control systems for authoring animated content using smart assets, automatically synthesizing new scenes from existing ones and integrating smart assets into virtual production scenarios.• A storage system for smart assets that combines local and cloud storage so that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Secure 5G-Enabled Twin Transition for Europe's TIMBER Industry Sector' (5G-TIMBER), addressing dissemination and exploitation.

assistant: **Impact**

5G-TIMBER project aims to validate through robust evidence the latest 5G Industrial Private Network features and standards specifications for Wood Value Chain (WVC) under realistic conditions. In particular, to conduct advanced field trials of the more representative and innovative data-driven material, production and installation flows that implicate manufacturing across 4 prominent industries in the wood sector including, machinery and wood house elements manufacturing, construction and renovation towards green buildings, wood waste valorisation, and established telecom SME industries in a project remit that spans 3 representative European regions (Norway, Estonia, Finland). The project incentivises the opportunistic uptake of 5G in real-life business conditions. Specifically, 5G- TIMBER will target to increase wood-based materials recycling by 50%, increase manufacturing productivity by 15%, reach 99% of the work done in the factory (vs. 85% today), reduce on-site work by 10%, reduce product nonconformities by 10%, and increase the safety of workers in wooden houses production and onsite assembling. Validation of above overall targets through >100 interdisciplinary innovation driven technical, business and service-level KPIs for 09 diverse WVC usecases across 3 categories i.e., data driven sawmill woodworking machines; modular wood-house factory; construction and renovation with wooden elements, valorisation of composite waste. Usecases will be incrementally validated by 2 lab trials followed by 2 field trials in iterative cycle covering significant portions of end-to-end WVC. 5G-TIMBER also includes a comprehensive business case and exploitation strategy that incorporates novel approaches to materializing the value of data produced in industrial environments based u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multimode light shaping: from optical fibers to nanodevices'.

assistant: **Concept**

The project MODES arises in the framework of the emerging interest for nonlinear multimode processes in optical fibers,  and wants to extend it to on-chip waveguides and nanoparticles, where the study of the nonlinear multimode dynamics is still on its infancy.This project is based on a central key-idea: by properly engineering a multimode system, we can shape and master the nonlinear interaction between the modes into play, and finally exploit it for novel applications in several strategic areas.This project has therefore a dual nature: one key-idea but multidisciplinary, heterogeneous applications.  It focuses on 4 main strategic areas (SA) and identifies an objective (OBJ) for each one, which is related to the exploitation of a specific  nonlinear multimode process:SA1: Support technology for Spatial Division Multiplexing (SDM) >>> OBJ1: the project investigates the development of wideband multimode wavelength converters and amplifiers SA2: High-capacity SDM data-transmission >>>OBJ2: the project investigates the existence of multimode solitons leading to an undistorted, high-quality propagation in multicore and multimode optical fibers SA3: On-chip infrared optical sources >>>OBJ3: the project targets the development of on-chip, widely tunable optical sources that may be used to selectively detect important environmental gases in the whole infrared spectrum SA4: Shaping the nonlinear radiation at nanoscale >>>OBJ4: the project aim at developing a new theoretical insight into the way higher-harmonic radiation is emitted in complex nanostructures. Finally, it wants to and to exploit this new knowledge in view of an ultrafast conversion from invisible to visible light.To conclude, by addressing new theoretical problems and unveiling a new multimode technology, MODES ai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Highly efficient technologies for increased yields in steelmaking processes and reduced environmental impact' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Steelmaking is a key process for a climate neutral, circular and digitized production. On one hand it enables green technologies in providing the most relevant materials needed to achieve climate neutrality, on the other hand it accounts for 7% of total world CO2 emissions. Its transition towards a more sustainable and still competitive production requires to increase the use of scrap to minimize the pig iron usage from coal fired blast furnaces with inherent CO2 emissions from reducing the iron ore. Furthermore, scrap can be valorised by use of carbon carriers and containing alloying elements in steel scrap, e.g. in recycling of Mn steels.HIYIELD aims to promote circular economy by progressively increasing the scrap uptake in three scenarios that represent the current European steelmaking routes. With the ambition to deliver solutions with relevance to all steelmakers, the consortium includes three producers with different portfolio. Main objectives are:-to maximise scrap quality by optimal technologies for removal of impurities and optimal use of alloying elements-to maximise scrap use by improved scrap identification and classification together with scrap tracking in circular economy-to maximise product quality with further scrap uptake by charge optimization and ensuring the liquid steel analysis and thus the final steel product qualityHIYIELD contributes to the fight against climate change and to the EU steel industry competitiveness through the application of highly innovative methods and technologies to the steel sector such as:-Deep Learning based Computer Vision for scrap identification and control-Digital Scrap Information Card for scrap tracking-High Speed Sampling and analysis to avoid waiting times for steel analysis.


**Keywords:** Sustainable steelmaking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Population pharmacokinetic-dynamic analysis of anticancer drug treatment'.

assistant: **Concept**

- Interpatient differences in the dose-response relationship for cytotoxic drug therapy in ovarian and breast cancer by applying a population PK-PD approach. Breast and ovarian cancer have been chosen as examples of common chemo sensitive yet often incurable tumours.- Quantitative relationships between interpatient differences in the exposure to anticancer agents and toxicities of the therapy. - Whether patients should benefit from individualized drug treatment. - Subpopulations of patients for which anticancer therapy has a low likelihood of tumour response, using a panel of tumour related pharmacodynamic markers (p53, Her-2/neu ER/PR, EGFR, LRP).- Subpopulations of patients which are particularly at risk; for the development of severe side effects.Patients with locally advanced or metastatic solid tumours vary widely in their response and tolerance of systemic therapy with anticancer agents. The variability in the dose-response and dose-toxicity relationship is determined by both pharmacokinetic (PK) and pharmacodynamic (PD) (tumour and end-organ related factors respectively). Application of the 'population approach' for characterization of variability in dose-response and dose-toxicity relationships as well as new insights in mechanisms of anticancer drug resistance, form the basis for the current large scale clinical-pharmacologic studies in patients with solid tumours. The studies will be carried out within the framework of the PAMM and ECSG and IDBBC-group of the EORTC. The population approach offers the possibility of gaining integrated information on PK, PD and response from sparse observational data and allows analysis of a variety of unbalanced study designs. Recent in vitro and in vivo studies have revealed that estrogen/progesteron (ER/PR) receptor status an