RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PrEP-ing at the end of HIV/AIDS: an anthropological study of Combination Prevention and PrEP in Argentina' in the context of a Horizon Europe call.

assistant: **Objectives**

PrEP-ing focuses on the implementation of Combination HIV Prevention (CP), the most comprehensive strategy of the Joint United Nations Program on HIV/AIDS (UNAIDS) in the current global effort to “End AIDS by 2030.” CP targets key populations, whose identification coincides with a higher HIV prevalence. Based on the notion that these groups have not responded to more conventional methods, the preventive use of antiretrovirals is prioritized, making Pre-Exposure Prophylaxis (PrEP) its key component. Following a scale-down in wide-ranging policies and programs (formerly a hallmark of HIV/AIDS governance), this strategy entails a more circumscribed biomedical prevention framework, in which antiretrovirals become the “magic-bullets” that protect communities from HIV and new individuals from getting infected. Against this backdrop, PrEP-ing seeks to re-center subjects and social relations through an ethnographic study of the production of this global HIV/AIDS policy in the specific national setting of Argentina. Drawing on insights from critical medical anthropology and studies on global health governance, the anthropology of policies and science and technology studies (STS), I aim to show how global-local entanglements involving biotechnologies, institutions, policymakers, health professionals, activists and PrEP users, come together in the making of CP. Argentina, a middle-income country situated in the global “South” and considered a model in the Latin American region for its early and sustained response to HIV/AIDS will provide a unique scenario to explore this subject. The main objective of this project is to describe and analyze the production of CP by a variety of actors. Taking the implementation of PrEP as a starting point, I seek to explore the constellation of act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EST programme to study the regulation of organ survival after transplantation' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Transplantation is often the only therapy for end-stage organ failure. The number of patients for whom this surgery is indicated is increasing but the number of available organs has remained relatively constant and waiting lists are growing. At present over 17,000 patients in the UK and Eurotransplant zones, which contain some 170 million people, are waiting for organ transplantation. The early success of transplant surgery is impressive with more than 80% of heart, kidney and liver grafts surviving for more than one year.However, most transplanted organs undergo a process of chronic rejection, which results in failure of more than half within 6-10 years. Chronic graft loss is now regarded as the greatest socio-economic problem associated with otherwise high ly successful transplant surgery. Few groups study the processes, which result in chronic graft loss and ours is almost unique in Europe in its capacity to provide comprehensive research training in this critical area. Our group in Newcastle combines non-clinical scientists with clinical academics from one of the largest and most comprehensive transplant programmes in Europe to produce a training environment, which has successfully helped 24 science and clinical trainees to achieve higher research degrees in the last 8 years.This proposal builds on a research hypothesis our group has developed recently to explain certain features of the chronic graft rejection process and will provide training opportunities for 4 EST candidates working in individually defined but complementary research areas. Of course, we hope that the results from these projects will directly combine to suggest novel therapeutic strategies to benefit European and global transplant recipients. However, we are entirely confident that our EST student
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EXPLORING THE FUNCTION OF EXTERNAL CALCIUM DYNAMICS IN AUDITORY HAIR CELLS' (2007-2013).

assistant: **Innovation**

Hair cells of the vertebrate cochlea have the remarkable property to transduce mechanical sound waves into electrical signals at the auditory nerve fibers. This sensory activity involves tightly regulated intracellular Ca2+ microdomains, both at the apical stereocilia level (Ca2+ influx through the mechano-sensitive channels) and the basolateral synaptic ribbon active zones (Ca2+ influx through L-type Ca2+ channels). Intense hair cell activity, that is spontaneous during development or evoked by sound stimulation in mature hair cells, should produce transient focal extracellular Ca2+changes ([Ca2+] ext) in the endolymph and synaptic clefts. The question of [Ca2+] ext signaling, while importantly addressed in central neurons, has never been investigated in auditory hair cells. Our preliminary results reveal for the first time a strong expression of the calcium sensing receptor (CaSR) in hair cells. CaSR is a G-protein-coupled membrane protein (GPCR) that detects small fluctuations in [Ca2+] ext. The goal of this application is to characterize the role of CaSR in mature and developing hair cell. We will develop a method for CaSR gene silencing using in-ovo electroporation in chick embryos. We will subsequently characterize any morphological and functional changes within the inner ear. Our proposed project could provide a novel view of Ca2+ homeostasis in the inner ear. This would increase our understanding of the function of Ca2+ signaling in the development of auditory system and maturation of hair cells. Interestingly, in humans, mutations in the gene coding for CaSR produce deafness. Thus, this study may also contribute to the treatment of hearing disorders whose pathology lies within the developing hair cells. This project and funding will serve as part of my training
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CONnecting EXcellence to UC3M' (CONEX), addressing dissemination and exploitation.

assistant: **Impact**

The Universidad Carlos III de Madrid (UC3M) proposes a new fellowship programme for incoming mobility, called CONEX - CONnecting EXcellence to UC3M. The main objective of CONEX is to provide excellent training and career development opportunities to researchers, so that funded researchers can make significant steps in their scientific careers.Through CONEX, researchers who are not resident in Spain are enabled to carry out extended periods of research in one of UC3M’s research institutes or research groups.Following 2 calls for proposals, the CONEX programme aims to offer 8 fellowships with a duration of 36 months to Very Experienced Professors (>10 years research experience) and 20 fellowships with a duration of 36 months to Experienced Professors (4 – 10 years research experience). Researchers are fully free in the choice of their research topic, institute and supervisor/mentor, to allow for a maximum benefit of the fellowship on their career development. To support the researchers in their career advancement, all researchers will have a supervisor or mentor and are required to set up and evaluate a Personal Career Development Plan. An ethical issues policy is put in place, in line with the FP7 rules on ethical issues.The evaluation is based on a peer-review process. The evaluation process and criteria are transparent and are communicated to the applicants through openly accessible applicant’s documentation and support mechanisms.The CONEX Programme is complementary to and coherent with other UC3M supported initiatives that currently facilitate mobility. CONEX is also expected to have positive effects on UC3M, in particular through its policy of ‘Concentrating talent’ and on the Spanish landscape in general. CONEX supports the objectives of the activity heading Life-l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multilingual On-Line Translation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

MOLTO's goal is to develop a set of tools for translatingtexts between multiple languages in real time with highquality. Languages are separate modules in the tool andcan be varied; prototypes covering a majority of the EU's23 official languages will be built.<br/>As its main technique, MOLTO uses domain-specific semanticgrammars and ontology-based interlinguas. These componentsare implemented in GF (Grammatical Framework), which is agrammar formalism where multiple languages are related bya common abstract syntax. GF has been applied in severalsmall-to-medium size domains, typically targeting up toten languages but MOLTO will scale this up in terms ofproductivity and applicability.<br/>A part of the scale-up is to increase the size of domainsand the number of languages. A more substantial part is tomake the technology accessible for domain experts without GFexpertise and minimize the effort needed for building atranslator. Ideally, this can be done by just extending alexicon and writing a set of example sentences.<br/>The most research-intensive parts of MOLTO are the two-wayinteroperability between ontology standards (OWL) and GFgrammars, and the extension of rule-based translation bystatistical methods. The OWL-GF interoperability willenable multilingual natural-language-based interaction withmachine-readable knowledge. The statistical methods willadd robustness to the system when desired. New methods willbe developed for combining GF grammars with statisticaltranslation, to the benefit of both.<br/>MOLTO technology will be released as open-source librarieswhich can be plugged in to standard translation tools andweb pages and thereby fit into standard workflows. It willbe demonstrated in web-based demos and applied in threecase studies: mathematical exercises in 15 l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Molecular mechanisms leading to cystatin c aggregation and amyloidosis in brain haemorrhage patients'.

assistant: **Objectives**

A point mutation in the gene for the human cysteine proteinase inhibitor, cystatin C, causes dementia and brain haemorrhage in patients with Hereditary Cystatin C Amyloid Angiopathy (HCCAA). The protein variant expressed as a result of the mutation, L68Q-cystatin C, is deposited as amyloid in the brain arteries of such patients. The current project aims at the characterization of L68Q-cystatin C, in order to elucidate the molecular mechanisms leading to cystatin C aggregation and amyloidosis and with the perspective to find means of inhibiting the aggregation and thereby prevent amyloid formation. To obtain L68Q-cystatin C in amounts allowing detailed study, expression systems will be developed for recombinant production in Saccharomyces or Aspergillus. Methods will be developed to allow in vitro measurements of the rate of formation of L68Q-cystatin C dimers and higher-order aggregates to define the path leading to amyloid formation. The structure of dimeric L68Q-cystatin C will be studied by NMR spectroscopy or X-ray crystallography, with the aim to develope low-molecular-weight inhibitors to the dimerization process, to be tested for potential as therapeutic agents by the in vitro methods developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Robotic Orbital Support Services In-Orbit Demonstration' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Access to Space is now easier and easier, and is not possible anymore to design and launch disposable spacecraft without considering the consequences: On-Orbit Servicing (OOS) is a first step towards this change of paradigm, as the technologies, typically autonomous rendezvous, refuelling, Orbital Replaceable Unit (ORU) exchange, repair and waste management with autonomous robotic tools will be used in future smart, flexible and modular space infrastructures. The growing demand for satellite life extension from commercial customers, making OOS an emerging market, is an opportunity to support those developments.To that purpose, designing in a phase B2/C the right mission and maturing the technologies to enable a go-to-market for future OOS missions is the main goal for €ROSS IOD. The objective is to enable the in-orbit demonstration of all the key capabilities: coordinated close rendezvous between two free flying spacecraft comparable in mass and inertia (a first in Europe) and autonomous robotic operations such as capture, refuelling and change of payload with a poly-articulated arm.In order to ensure a sound and low-cost solution, the project leverages on the previous developments carried out for the last 6 years within the Strategic Research Cluster (SRC) on Space Robotics technologies, particularly in continuity of the past project EROSS and the current project EROSS+.The final aim of the €ROSS IOD project is to prepare and carry out the last remaining steps to fly a European pioneering mission by 2026 with a customer-driven approach.Thales Alenia Space, with GMV, DLR and 14 European technology providers (research centres, large, medium and small companies including one start-up), is following its plan to commercialise a multipurpose servicer for LEO and GEO servicin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support for Mediation And bRokering for Electronic Commerce' in the context of a Fifth Framework call.

assistant: **Objectives**

The objective of the SMART EC project is to create an intermediation platform for the provision of complex services on Internet.The SMART EC platform will provide the following services:- As defined above, brokering of services between individual service providers and final users requesting complex services.- Definition and implementation of the life cycle of a complex service, include the required steps for the service provision and the transactional properties of the service.- One stop shopping, form multi-items purchases giving access to multiple e-commerce sites. Access to this powerful platform will be possible by three means of WWW terminal.Work description:For the understanding of the project, a scenario of usage is presented as an example. References to architectural components are included. A complex service that SMART EC is able to provide can be a holidays' trip. This includes some flight tickets, hotel booking, information on museums and tours, etc. SMART EC will get the request, decomposing it into a number of individual services, according to the models included in the Knowledge and E-Commerce Ontologies module. Each of these services will have its on ontology and properties, but the Virtual Service Layer will combine then according to the properties included in the Process Management module and if the citizen is usual visitor, their preferences may be registered in the User Customisation module. The Broker Platform, according to all this information will call the suitable Contents and Service Providers (CP/SP). The Transaction Management module ensure that transactional properties for the whole service are considered and the E-Commerce Platform will incorporate shop-mart and paying services. Finally, the Contract Management module will incorporate additio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Factors Influencing the Educational Inequality of Young People: A European and Comparative Perspective' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The education of young people is one of the great challenges facing European governments. Education is a crucial investment both for the country as a whole (ensuring economic competitiveness and social integration) and for the individuals concerned, in helping them to find skilled and secure employment. Whereas a considerable amount of comparative research has already been carried out on national differences in average levels of educational attainment, our focus is on educational inequality, that is, on variation around the average.We aim to understand not only why some individuals have lower educational attainments but also why educational inequalities are greater in some European countries than in others. This project builds on the work of Shavit and Blossfeld (1993) who carried out a pioneering study of class inequalities in education in thirteen countries. However, their study focused primarily on class inequalities in education and was primarily descriptive. Moreover, their study was based on different national data sets in each country. Since Shavit and Blossfeld's day there has been the emergence of systematic cross-national data sets which permit much more rigorous cross-national research and will provide the main basis for our project. We shall draw extensively on the data collected for the Programme for International Student Assessment.This will enable us to gain deeper understanding of the sources of national differences in educational inequality. We will supplement this with analyses of other recent cross-national datasets such as the European Community Household Panel Study and the European Social Survey. The project will make a substantial contribution to a key European policy area by drawing on best practice from the disciplines that have contributed to t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a novel instrument for viscoelastic characterization of food and biological materials' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The purpose of this study is to develop a new oscillatory squeezing flow instrument for viscoelastic characterization of materials, ranging from very soft biological polymer networks to irregularly shaped solid materials like corn grains. This relatively low-cost and easy-to-use instrument will be suitable to be used as an attachment for commonly available instruments such as the Texture Analyser and Universal Testing Machine, and will make these instruments suitable for frequency sweep type viscoelastic measurements.The dynamic mass of the instrument will be extremely low compared to the conventional instruments, allowing it to reach relatively higher frequencies with very high sensitivity. The proposed method will be tested by using important representative samples from many different scientific disciplines, such as food science, biology, pharmacy, and chemistry.The instrument will be operating with random frequency excitation and will be able to produce large amounts of data in a very short time. In order to validate the results obtained at high frequencies (>100 Hz), the microrheological technique called Diffusing Wave Spectroscopy will be used, and low-frequency data will be validated with a conventional rotational rheometer. This proposal outlines the setup details and working principles of the proposed instrument and the research methodology to validate it.