RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Restriction of HIV and coronavirus infections by the innate immunity protein Shiftless' in the context of a Horizon 2020 call.

assistant: **Objectives**

Programmed ribosomal frameshifting (PRF) is a mechanism of recoding that allows synthesis of multiple proteins from the same mRNA by shifting the translation reading frame. Many viruses, including medically important HIV and coronaviruses rely on PRF to increase their coding capacity and modulate appropriate stoichiometric ratios of viral proteins. An interferon-inducible restriction factor Shiftless (SFL) can block the frameshifting required for viral translation and infectivity. Understanding the mechanism of action of SFL will undoubtedly guide the design of new antiviral therapeutics. However, most structural and functional aspects of SFL and its role in viral infections are unknown. We intend to characterise the role of SFL in HIV and coronavirus infections using a three-pronged approach: (i) We will elucidate the mechanism of inhibition of PRF on viral mRNAs by SFL using a state-of-the-art in vitro reconstituted translation system and depletion/deletion of SFL in human cell lines. (ii) We will determine the interaction of SFL, translating ribosome and frameshifting viral mRNAs using cryo-electron microscopy. (iii) Based on the structural data obtained, we will generate mutants of SFL and characterise their activities by in vitro and cellular translation assays to identify specific domains and amino acid residues required for the antiviral activity of SFL. The results expected from our proposed study should not only be crucial for understanding the molecular mechanism of SFL but should also provide vital inputs to the development of antiviral therapeutic agents by either mimicking or upregulating SFL expression against critically important viruses such as HIV and SARS-CoV-2. Importantly, our research should continue to be relevant for the treatment of any future fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intelligent and Sustainable Building Management powered by Cross-Sectoral Lifecycle', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

DATAWiSE will develop and test building and building portfolio management tools, leveraging cross-sectoral lifecycle data on the basis of an open, secure, interoperable, and scalable framework.  Utilizing cutting-edge artificial intelligence and advanced analytics, the methodology will integrate data from a variety of sources to provide a holistic understanding of building operations. DATAWiSE will design and implement a scalable data architecture that ensures data quality, privacy, interoperability, and sharing, and a Data Sharing Platform that will not only ensure interoperability and scalability but will also prioritize data sovereignty to secure data handling and preserve ownership control. DATAWiSE will develop: i) a Data-driven Building Performance Management (DBPM) toolkit which will harness Building Information Modeling (BIM) data in conjunction with advanced data mining techniques through a digital twin. ii) An AI-enhanced Lifecycle Data-driven Decision Support (LD2S) toolkit. This will serve as a versatile solution for well-informed decision-making across planning, renovation, and sustainability domains. Through these tools, the project will offer a suite of added-value services aimed at optimizing building management in various aspects: Electrical and Thermal Flexibility Management; AI-Powered Energy Forecasting and Optimization; Smart Sustainability & Comfort Balancing for Building Occupants; Adaptive Building Risk & Resilience Assessment; Circular Lifecycle Assessment; Predictive Maintenance; Integrated Sustainability Performance Management; Smart Readiness Assessment. Besides technological innovation, the project also incorporates a supportive market and policy framework designed to offer evidence-based pathways for widespread adoption and commercializatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stability of one-dimensional chapman-jouguet detonations' in the context of a Fourth Framework call.

assistant: **Objectives**

In this project we propose to investigate the stability of one-dimensional CJ det- onations by use of analytic and numerical methods. The proposed investigation is intended to identify the physical mechanism triggering the oscillations in Chapman- Jouguet detonations, an issue that needs to be resolved before more complex ques- tions, concerning the generation of the three-dimensional cellular structures, can be addressed. First, the stability problem will be formulated and asymptotic methods will be employed to derive the equation (or equations) that govern the dynamical behavior of CJ detonations. Solution to the problem will provide the stability limits and exhibit the parametric dependence of the solution. In addition to a suitable model previously developed for the study of overdriven detonations, reduced hydrogen- oxygen chemistry will be employed to obtain the heat-release rate in the shocked gas. Comparisons with results of direct numerical simulations will be made to test the parametric dependence and the accuracy of the predictions obtained by the asymptotic analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AUTOMATED CALL CENTER THROUGH SPEECH UNDERSTANDING SYSTEM' (ACCESS).

assistant: **Concept**

ACCESS is developing call centre technology for the insurance industry to automate handling of customer claims and enquiries. Applications will deal automatically with incoming telephone calls, recognising and understanding what is being said, or received by fax or mail, in the case of written material. Besides routine calls, the centre is also intended to handle special situations, such as an exceptional volume of enquiries after advertising campaigns. The initial focus will be on standard contract matters, with subsequent development to cover more complex issues like vehicle damage reports.The initial phases of this project have been concerned primarily with general market assessment and definition of specific user requirements. The project has the benefit of the committed participation of two insurance companies: Tellit in Germany and Interamerican in Greece. With their help the functions of an initial demonstrator were specified and plans for integration, evaluation and testing completed. An early version of the demonstrator is already running. Analysis has been carried on relevant human dialogues as well as the process of automatically filling an insurance claim form using a computer directed dialogue with the customer. In practice, this work indicates that the project is very ambitious and will need highly advanced technology. Implementation of the ACCeSS system is in progress and will lead to a demonstrator in the insurance environment at the end of 1997. Market Prospects Telebusiness is an important part of one of the fastest growing markets in the world: the telecommunications market. Analysis has shown significant growth in the market for voice products, in general, and call centres, in particular. Customers have high expectations of support provided over the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Vortex interactions in two-dimensional turbulence analysed using wavelets and wavelet packets' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Direct Numerical Simulations (DNS) have shown that coherent vortices pl an essential role in two-dimensional (2D) turbulent flow dynamics. Classical statistical theories of 2D turbulence describe the average behaviour of ensembles of many real- isations of a turbulent flow and hence cannot account for the appearance and effect of vortices in a given realisation. This fact suggests that an understanding of vor- tices and their interactions is necessary to understand 2D turbulence, and that the vortical structure of 2D turbulence may be used to construct more efficient numerical simulations.  The research proposed here has two objectives: the first is to analyse the nonlin- ear interactions of vortices. This analysis will use a new mathematical technique. the wavelet transform, to relate physical structure to spectral quantities. We first con- sider a highly nonlinear elementary interaction: the merger of two positive vortices in the presence of a negative vortex. We then analyse the more complicated nonlinear interactions of a fully turbulent flow when many vortices have been formed. The second objective is to develop a more efficient and physically realistic way of numerically simulating turbulence bv compressing the vorticity field using a wavelet packet basis. The largest wavelet packet modes have been found to correspond physi- cally to the large vortices in a turbulent flow making this simulation method particu- larly appropriate for following the dynamics of coherent vortices in fully developed 2D turbulent flows. The Navier-Stokes equations will be solved on a wavelet packet basis and the vorticity field will be compressed by keeping the minimum number of wavelet modes required to retain a specified fraction of the total enstrophy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Eco-evolutionary feedback as an engine for maintaining biological diversity in heterogeneous landscapes: toward landscape-level theory of eco-evolutionary dynamics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the last two decades, studies have revealed that evolutionary changes can occur rapidly on ecological timescales. This indicates that ecological and evolutionary processes can interact and influence one another; this phenomenon is called eco-evolutionary dynamics. For eco-evolutionary dynamics to occur, populations need to harbour sufficient standing genetic variation. Many factors influence genetic variation, one of which is spatial population structure. Many populations living in heterogeneous landscapes occur as spatially subdivided populations connected by dispersal, known as metapopulations. Habitat network structure (spatial configuration of habitat patches) influences not only the demography of metapopulations but also the distribution of genetic materials by mediating population size and gene flow. This implies that eco-evolutionarily dynamic responses may be spatially unevenly distributed in heterogeneous landscapes. The mosaic of eco-evolutionary coupling could be partly predictable from habitat network structure and the movement of organisms. The goal of this project is to investigate how habitat network structure can shape the spatial structure of standing genetic variation in metapopulations and, consequently, how it can influence spatial eco-evolutionary dynamics. This project will build a theoretical understanding of the effects of major dimensions of habitat network structure on genetic variation and local adaptation in metapopulations. The model will be applied to ecologically and genetically well-characterised empirical metapopulations studied by the supervisor. This project will combine eco-evolutionary metapopulation modelling and genomic and field population data to mechanistically understand the role of space in eco-evolutionary dynamics. I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A rapid, low-cost, cervical cancer screening platform' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Cervical cancer causes 13.000 deaths and 34.000 new cases in the European Union. 200M tests are performed worldwide per year representing a $3,4B market.Today two tests are performed to diagnose cervical cancer. Firstly, a cervical smear is analysed by a pathologist via a visual subjective inspection using traditional microscopy. This is an 8-step process performed by several persons at different locations. Secondly, if positive, a molecular 4-step HPV test is performed. Results are available after 3 to 4 weeks causing anxiety and frustration for the patient. Typical instruments are expensive and have high related operational costs.Ovizio has designed a direct read vial allowing for the sample to be directly analysed without manipulation. The technology automatically generates objective data, identifying cells, detecting malicious cells and combines cytology and HPV in one test. This is a 3-step process: 1. sampling, 2. analysing, 3. report generation. The test is performed on a small low-cost device giving results in minutes rather than days allowing for near patient testing.A proof of concept and alpha prototype have been built with basic software algorithms. Several test have been performed at hospitals in Belgium and France resulting in two scientific publications and enthusiasm from key opinion leaders.The breakthrough technology transforms microscopic images into actionable data, corresponding to a market need of faster and improved testing, allowing healthcare organisations of member states to reduce costs and improve testing ratio’s. The company has a team that has done it before completed with highly skilled subject experts in the field and has launched 3 products laying the foundations for this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reliable biomeTric tEchNologies to asSist Police authorities in cOmbating terrorism and oRganized crime' in the context of a Horizon Europe call.

assistant: **Objectives**

TENSOR will provide LEAs a platform that facilitates the biometric evidence extraction, sharing and storage in cross border environments allowing them to share best practices in an automated, robust, secure, privacy-preserving and scalable manner. In addition, the full potential of biometrics technologies will be exploited and their fusion in case of partial evidence gathered in the crime scenes by forensic institutes strengthening their acceptance in the court of justice. More particularly, TENSOR will equip security practitioners with novel tools focusing on (a) Extraction of biometrics and other more or less distinctive features validated in forensic conditions that assist LEAs in identification, identity verification, intelligence and investigation processes and can be leveraged to identify the owner of mobile devices found at crime scenes; (b) Sharing of biometrics through secure, automated, scalable exchange of biometric intelligence and court-proof evidence among LEAs in a cross-border manner, enabling seamless collaboration among existing systems used by security practitioners and Forensic Institutes; and (c) Storage of biometrics in a privacy-preserving way through a biometric data protection mechanism enabling revocability of biometric templates. TENSOR will also introduce the one-of-its-kind European Biometric Data Space creating a common ground among LEAs, Forensic Institutes and Security Researchers assisting in the faster adoption of modern biometric solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OF INFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA' (INFANTLEUKEMIA).

assistant: **Innovation**

Infant cancer is very distinct to adult cancer and it is progressively seen as a developmental disease. An intriguing infant cancer is the t(4;11) acute lymphoblastic leukemia (ALL) characterized by the hallmark rearrangement MLL-AF4 (MA4), and associated with dismal prognosis. The 100% concordance in twins and its prenatal onset suggest an extremely rapid disease progression. Many key issues remain elusive:  Is MA4 leukemogenic?  Which are other relevant oncogenic drivers?  Which is the nature of the cell transformed by MA4? Which is the leukemia-initiating cell (LIC)? Does this ALL follow a hierarchical or stochastic cancer model? How to explain therapy resistance and CNS involvement? To what extent do genetics vs epigenetics contribute this ALL?These questions remain a challenge due to: 1) the absence of prospective studies on diagnostic/remission-matched samples, 2) the lack of models which faithfully reproduce the disease and 3) a surprising genomic stability of this ALL.I hypothesize that a Multilayer-Omics to function approach in patient blasts and early human hematopoietic stem/progenitor cells (HSPC) is required to fully scrutinize the biology underlying this life-threatening leukemia. I will perform genome-wide studies on the mutational landscape, DNA and H3K79 methylation profiles, and transcriptome on a uniquely available, large cohort of diagnostic/remission-matched samples. Omics data integration will provide unprecedented information about oncogenic drivers which must be analyzed in ground-breaking functional assays using patient blasts and early HSPCs carrying a CRISPR/Cas9-mediated locus/allele-specific t(4;11). Serial xenografts combined with exome-seq in paired diagnostic samples and xenografts will identify the LIC and determine whether variegated ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spiking neural models of auditory perception' (SPIKEHEAR) under Seventh Framework.

assistant: **Objectives**

In classical connectionism, the information is conveyed by the firing rate of neurons. Spiking neuron models offer an additional dimension to the rate: synchrony. Synchronous spike trains are more effective than uncorrelated ones in driving the responses of target neurons. Because neurons can encode their inputs in a sequence of precisely timed spikes, input similarity translates into synchronous spiking, which can be easily detected by afferent neurons. The dual properties of synchronization and coincidence detection lead to a new computing paradigm, where neurons perform a similarity operation instead of a summation. Because synaptic plasticity favor correlated neuron groups, synchrony-based computation should play an important role in developed neural circuits. The presence of neural correlations has been demonstrated in early sensory systems, but their computational role is still unclear. In auditory perception, the fine temporal structure of sounds is thought to play an important role, in particular for pitch perception and spatial localization of sounds. It has long been proposed that the auditory system exploits the structure of neural correlations to infer information about those properties, but it is still unclear how this computation is physiologically implemented. In this project, I propose to investigate synchrony-based computation and learning in the auditory system, using computational neural modeling. The expected impact of the project is 1) the development of spike-based neural network theory, 2) a better understanding of the role of neural synchronization in auditory perception, 3) industrial applications (music transcription, auditory scene analysis) and medical applications (stimulation procedures for cochlear implants) with neural simulation technolo