RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of DNA methylation in the regulation of lincRNAs in Hematological Malignancies' (LINCMHEM).

assistant: **Concept**

Traditionally, cancer researchers have focused their best efforts on studying the genetic alterations affecting the coding genes. Subsequently, it was observed that in addition to genetic alterations, epigenetic alterations affecting coding genes play an important role in tumor development. In the last decade, largely due to the ability to sequence the human genome and the observation that much of the genome is transcribed but not translated, genes known as ""non-coding RNAs"" (ncRNAs) have attracted great interest in relation to their biological functions and their role in human tumors. In addition to the small ncRNAs like miRNAs, is also revealing that the human genome also encodes numerous long non-coding RNAs (lncRNAs). Some of these lncRNAs are being found in the intergenic regions of the genome (long intergenic non-coding RNAs - lincRNAs). It is estimated that there may be more than 8000 lincRNAs in the human genome. The mechanism that regulates these lincRNAs and the functional mechanism of the vast majority of these lincRNAs are not known, but the few that have been studied are known to exert their function in the nucleus and to be involved in chromatin remodeling and transcription regulation. The expression of lincRNAs is altered in cancer, playing an important role in the initiation, prognosis and progression of human neoplasies. In this regard, preliminary results from our group show that DNA methylation may play an important role in the regulation of lincRNAs and probably in the pathogenesis of hematological malignancies.For all these reasons, the objectives of this “LincMHeM” proposal are to determine whether inappropriate DNA methylation is involved in regulating lincRNA expression, and if such deregulated lincRNAs are involved in pathogenesis and are pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'non-linear and adaptive control: tools and algorithms for the user'.

assistant: **Innovation**

The network participants will organize periodical events, such as schools and workshops, to present classical results and up-to-date contributions in the areas of non-linear adaptive control, with particular emphasis on constructive design methods. More precisely, tutorial schools on Model Predictive Control", "Modeling and Control of Physical Systems" and "Adaptive Non-linear Control" and workshops on novel contributions will be organized. Experts in the various disciplines, both from the network participants and from other institutions, will be invited to contribute to the training programme of young researchers. The training activity will be co-ordinated with other existing networks and programmes to improve interdisciplinary communication and reduce the financial effort. The young researchers participating in the network activities will also have the opportunity to attend the courses of the Master of Science Programme in Control at Imperial College and of the Italian PHD Summer School. Despite the predominant theoretical flavor, the proposed programme is of fundamental methodological relevance to train new engineers."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biomimicking nanostructured materials via intra(inter)molecular folding of sequence-controlled polymers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nature employs various polymerization processes (e.g. DNA replication, transcription and translation of proteins) in order to synthesize biopolymers such as DNA and proteins with controlled sequences and configurations. Such remarkable and complicated structures can fold into precise nanostructures via intramolecular and intermolecular interactions and thus replicating these domains via synthetic polymers has recently attracted considerable interest. The goal of BINAMA is to synthesize biomimicking nanostructure materials via intramolecular folding of sequence-controlled polymers in the presence of a “real” catalyst/chaperone, thus mimicking the intracellular environment. For the first part of the project, the sequence of functional monomers will be controlled utilizing controlled living radical polymerization methods. Subsequently, the incorporation of these monomers will induce hydrogen bonding, hydrophobic/hydrophobic, pi-pi, charge and disulphide interactions typically employed by proteins in order to facilitate the controlled folding of the polymer chains, adopting natural motifs and patterns. The ability to mimic these perfectly defined sequence-controlled polymers (e.g. DNA and proteins) via synthetic polymer chemistry will pave the way for synthetic bioanalogues and could also enhance their functions and properties.


**Keywords:** sequence controlled polymers, biomimicking materials, intra and intermolecular interactions, ATRP, RAFT
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Avalanche and landslip early reporting technology'.

assistant: **Objectives**

This research is aimed at finding the most suitable heating system for not continous use in churches. The heating system will be tested and developed also for a good energetic efficiency, so that the technology will lesscn the impact on the natural environment. Churches preserve infact an immense number of works of art: paintings on canvas or tablets, frescoes, statues, decorations, ancient books, tapestries and so on. This patrimony is often at risk in absolutely inappropriate conditions of heating, as nowadays people require a comfortable climate during the day of the liturgy. The SMEs proposers are looking forward to cooperate in defining and producing a heating system suitable both for people and works of art preserved in churches. Besides they intend to develop a monitoring system able to describe ambient parameters variation, in ordcr to avoid the artefacts damage. The system will monitor parameters such as temperature, humidity, indoor ventilation and infrared and ultraviolet components in lighting systems. One of the aims of this project is to stimulate the industrial research and production in this field and arrive at a global demonstrative example (i.e. including heating, insulating and ambient monitoring) that will be scientifically evaluated in order to remove any doubt to whoever is interested to follow it. The scientific and technical objectives of this research proposal concern: the exploration of characteristics and dynamics of avalanches and landslips the development of suitable hardware components (sensor systems) for the prediction of avalanche i landslip events the development of suitable software components (algorithms, programs) for event predictionintegration of hardware and software components to an EARLY WARNING SYSTEM (EWS)" As a result of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Treatment and recycling of photographic effluents' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Project objective is development of a simple and efficient system for treatment of polluted washing water coming out photo film development and printing process. The system will be based on Reverse Osmosis (RO) technology, that is spreading over the field of water purification for its low costs, simplicity, efficiency, low environmental impact and durability. Actually washing water is inactivated by through an ozone cleaning system and then discharged to sewer,. this way both environmental and economical problems are caused, as water still containing chemicals is wasted to sewer. By using RO technology it could be possible to save more than 95% of washing water and to reduce the purifying system costs of about 30%. The project outputs will bring a series of advantages: reduced production costs resulting in an increased competitiveness of SMEs; low environmental impact due to the recycling of water; possibility of operating in continuous; easy and rapid purification process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nuclear structure investigation of mirror nuclei via lifetime measurements' (1998-2002).

assistant: **Innovation**

The existing methods for determination of lifetimes of excited nuclear states using the DSA technique will be improved. Three DSAM experiments will be performed to investigate transition rates in mirror nuclei, the charge symmetry of nuclear forces, and the correctness of Shell model calculations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Application of in situ techniques to real environmental catalytic processes'.

assistant: **Innovation**

In the 21st century, heterogeneous catalysis research should focus on achieving 100% selectivity for the desired product in all catalyst-based processes. However, this can only be achieved by understanding the fundamental steps of the reaction mechanisms, which allow better design of a catalyst with optimized performance with respect to selectivity and activity. With the development of surface science in the early 70s fundamental studies led to discovery, development and enhanced understanding of several catalyst systems. Many of the early surface science techniques along with the newly develop techniques continue to and will play a very important role in the future development of next generation catalysts and catalytic processes for the industrial use and environmental protection. This project will incorporate new techniques in the catalysis field to obtain valuable surface science information for the improvement of catalysis applied for environmental problems. This will be performed by the investigations of two different hydrogenation environmental reactions, (hydrodechlorination of trichloroethylene in gas phase using Pt,Pd-ternary hydrotalcites and the reduction of nitrates in water streams for drinking water using Pt/CeO2 catalysts), using in situ SFG (Laser spectroscopy by sum frequency generation) and Transmission and ATR (attenuated total reflection) Fourier transform infrared techniques. A better understanding of the reaction mechanism will allow the design of catalysts with optimized performance. The main novelty of the project consists in the application of SFG techniques, used till now for single crystals or model systems, to real catalytic processes. In liquid phase systems, SFG will allow us to specify the species at the surface without contributions from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SIngle Molecule DEtection and Quantification (SIMDEQ): A new platform for genetic and epigenetic analysis' (SIMDEQ).

assistant: **Concept**

The purpose of the proposed project is to investigate the commercialisation potential of an innovative technology that has been developed in my lab with ERC funding.  For over 15 years, our laboratory at the Ecole Normale Supérieure of the Centre Nationale de la Recherche Scientifique (CNRS) has been developing an instrument called a ‘magnetic trap’. Initially developed in order to study the mechanisms of DNA replication and repair, we have discovered in the past few years that this instrument can also be used to extract both genetic and epigenetic information from single molecules of DNA. The highly novel approach we have developed is called SIMDEQTM (short for ‘SIngle-molecule Magnetic DEtection and Quantification’). We have shown that it can be used to rapidly identify, map, quantify, and fully sequence DNA fragments present in a genetic sample. In addition, a unique feature of the technology is that it can detect and locate the naturally-occurring biochemical modifications to DNA’s four bases (e.g. methylation). There is substantial commercial interest in reading these ‘epigenetic’ modifications as they are important in areas such as developmental biology, cancer, and microbial virulence.The SIMDEQTM approach to genetic analysis is simple, elegant, and combines the DNA mapping and sequencing abilities of current instruments with the revolutionary ability to directly detect a wide range of DNA modifications at single base resolution.  We believe SIMDEQTM could be a disruptive technology across a wide range of research and diagnostics sectors, but recognize that this is a dynamic field with many competitors and specialized niches. We therefore hope to investigate the market potential of this technology and identify the most promising applications through the work desc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mechanisms underlying Wnt-induced DNA Damage Response in primary human breast epithelial cells' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Wnt signaling is important in many developmental processes and has been implicated in tumorigenesis and in degenerative diseases. In normal cells, Wnt family proteins act through the well characterized canonical or less well understood non-canonical signaling pathways. While the canonical pathways proceed through the stabilization of beta-catenin, the non-canonical ones involve several effectors including protein kinases such as JNK, a member of the Stress Activated Protein Kinases family, which is activated by a variety of extracellular stimuli (Weston et al.). The Brisken laboratory has recently shown that increased Wnt signaling in primary human breast epithelial cells (HBECs) triggers a cascade of events resulting in oncogenic conversion of these cells (Ayyanan, A., et al). They found that an early event triggered by ectopic Wnt-1 expression is the activation of the DNA Damage Response (DDR). A hallmark of DDR is the phosphorylation state of the histone H2AX since phosphorylation of H2AX is induced in response to DSBs (double stranded breaks) originating from diverse origins including external damage (E.P. Rogakou et al.; T.T. Paull et al.), replication fork collision (T. Furuta, et al.;  I.M. Ward et al.), apoptosis (E.P. Rogakou, et al.), and dysfunctional telomeres (F. d’Adda di Fagagna et al.;.H. Takai et al.). Recently, it has been shown that H2AX could be phosphorylated by JNK. The goal of this project is to determine which signaling cascades are activated by Wnt-1 in primary HBECs, and to test the hypothesis that activation of JNK leads to phosphorylation of H2AX thereby triggering the DDR. This will help to uncover the nature of molecular mechanisms activated by Wnt that could be targets of molecular or pharmacological therapies to breast cancers where Wnt s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Body Scan for Cancer Detection using Quantum Technology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

We propose to develop a radically new unified technological concept of biomedical detection utilizing front line new ideas in quantum optics and quantum mechanics. The new concept will be based on unified transmission and detection of photons in a three dimensional space of orbital angular momentum, entanglement and hyper-spectral characteristics (OES). These will enable a revolutionary scanner capable of detecting cancer not only in a specified organ but in various parts of the body at once, even from remote locations, and with no radiation risk whatsoever. Our pilot project will be focused on the early detection of breast cancer. Mammography, as the state of the art method for breast cancer screening, is limited in its sensitivity especially in younger women and/or women with dense breasts, and has been found to be problematic in women with genetic mutations. Thus the development of an improved and more reliable detection method is of paramount importance. A novel detection algorithm will be developed based on clinical trials in breast cancer patients, using the unified transmission and detection theory. We chose to verify our concept in the area of breast cancer due to its prevalence and the condition that feeds our concept (large amount of tissue without bone). In the long term this approach can be adapted to other areas of bio-medical diagnostics leading to total mass screening. The concept is based on non invasive utilization of light and its ramifications are numerous.In the proposed project, the endeavor will be both theoretical and experimental including derivation of a mathematicalmodel and development of an experimental bio-compatible test-bed for cancer detection with minimal false positives.Our joint knowledge places the project at the cutting edge of scien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Online Service of Personalised Games for People with Cerebral Palsy to Enhance their Abilities and Living Adjustment'.

assistant: **Objectives**

Cerebral Palsy (CP) is a frequent neurological disorder (2 per 1k births). The EU has 0.7m of 17m persons with CP globally. Therapy can cost €45k/year - a huge burden on families. Playing digital games, as Europe 2020 identifies, can promote health & well-being for people with such disabilities. AbleGames will be a disruptively innovative social-collaboration serious gaming platform to personalise & improve the physical therapy, peer community inclusion, quality of life & enjoyment of people with CP. There are many game platforms (e.g. Steam, Origin, Epic), but none for, or usable by, people with CP. Our platform will constantly adapt multiplayer top-quality games to each individual’s abilities to foster rehabilitation progress & social collaboration using AI technologies. The players will interact with non-immersive virtual reality scenarios using balance sensors & smart low-cost vision systems based on machine learning models. A TRL9 commercial service will be on the market within 3 years, using the innovative concepts proven in the successful GABLE H2020 serious gaming project (GA732363). Currently at TRL6, the system’s productisation will be fast-tracked to operate/demonstrate it at diverse reference clinics. HuginTech (a major provider of games on multiple platforms) will drive its commercialisation & service productisation. Based on market requirements & ongoing feedback from 7 pilot sites, the project will disseminate AbleGames to potential purchasers & users through various media & events, & validate/refine our Business Plan to deploy by domestic & institutional subscription market channels strategy. The first targeted segment is youths with CP, where the Partners have competitive advantage - based on success in that niche to address further remedial & learning