RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of intracellular receptors for calcium release in normal and abnormal brain function' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To obtain the full sequence of the recently identified new ryanodine receptor (RYR) and inositol 1,4,5-trisphosphate receptor (IP3R).To completely screen the expression of all known RYR- and IP3R-isoforms in normal brain and in tissues and cells from patients with neurological disorders.To determine how these receptors function to gate Ca2+ in neuronal tissues.To understand the role of RYRs and IP3Rs for brain function.Ca2+ is an important intracellular messenger in brain. There are 2 intracellular channels responsible for releasing stored Ca2+: RYRs and IP3Rs. A further exploration of the role of these internal receptors in brain is urgently needed since these channels are the targets of neurotransmitter receptors involved in cognitive processes of long-term potentiation, long-term depression and spatial and motor learning. Alterations in the IP3 signalling pathway may contribute to e.g. Alzheimer's disease and manic-depressive illness. Also RYRs may be involved in abnormal brain function as malignant hyperthermia susceptible pigs express a mutant RYR in the brain as well as in skeletal muscle and are highly susceptible to stress. Considering the central role of these internal receptors in so many aspects of brain function, it is surprising that so little is known about their basic properties in brain. The current project therefore aims to understand the distribution, structure and physiology of the RYRs and IP3Rs in normal and abnormal brain function.To determine how these receptors function to gate Ca2+ in neuronal tissues, we will focus on Ca2+ and cyclic ADP-ribose (cADPR). Ca2+ is an activator of both RYRs and IP3Rs. We will establish whether all members of both receptor families behave similarly and the mode of activation will be characterised at the protein leve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'European Bank for induced pluripotent Stem Cells'.

assistant: **Concept**

EBiSC is designed to address the increasing demand by iPSC researchers for quality-controlled, disease-relevant research grade iPSC lines, data and cell services. Its goal is to demonstrate an operational banking and distribution service of iPSC lines after 3 years and to establish subsequently for Europe a centralised, not-for-profit bank providing all qualified users with access to scalable, cost-efficient and customised products.  The EBiSC Consortium including EFPIA partners boasts the leadership, scientific expertise, facilities, networks and experience to achieve these goals and, being representative of all stakeholders from tissue donors to clinical and academic iPSC researchers and industrial users, to respond appropriately to advances in science and society.  Led by Pfizer Ltd and managed by Roslin Cells, the Consortium comprises 8 active participant iPSC Centres with clinical and patient networks, a global leader in industrial iPSC supply, international experts in iPSC science, biobanking, bioengineering and regenerative medicine, and scholars in law and ethics.  The main facility will be at the Babraham Research Campus (Cambridge, UK) and will undertake cell expansion, QC and characterisation. The European Cell Culture Collection (ECACC) of Public Health England (Department of Health, UK) will coordinate cell line distribution. The Fraunhofer IBMT (Saarbrücken, Germany) will provide comprehensive operational back up.  EBiSC’s capacity will be 10,000 cell lines; it will eventually process over 1,000 lines in annual sales.  In a phased business strategy EBiSC will hot-start distribution of lines contributed by iPSC Centres in 2014, lines collected based on specified user demand, will reach full scale operations in 2016, and with extended funding will become sel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'International tax competition and its interaction with the exchange rate coordination' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

There is a gap in the existing literature concerning the optimal degre of fiscal integration in a monetary union.  My research aims to investigate the interaction of capital income tax with the exchange rate policy in a world economy.  An important issue in this context is whether the introduction of a common currency in a union requires a coordination of fiscal policies between member countries. In such a world, countries can behave strategically by using both their tax and exchange rate policies in order to attract world resources.  To capture this element I will use a game theoretic approach in a general equilibrium framework.  This area of research seems very promising, especially now that international considerations have become increasingly relevant in the analysis and formulation of policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In-line and Real-time digital nano-characterization technologies for the high yield manufacturing of Flexible Organic Electronics' in the context of a Horizon 2020 call.

assistant: **Objectives**

RealNano is an ambitious 36-month project that will develop rapid real-time nano-characterization materials tools & methodologies based on Spectroscopic Ellipsometry, Raman Spectroscopy, Imaging Photoluminescence and Laser Beam Induced Current Mapping that will be integrated to in-line R2R (Roll-to-Roll) Printing and OVPD (Organic Vapor Phase Deposition) Pilot-to-Production Lines (PPLs) for characterization of Organic & Printed Electronics (OE) nano- materials, layers, devices and products during their manufacturing. It will bring Digital Intelligence to manufacturing by combining, fast and non-destructive characterization tools and methodologies (high speed resolution at nanoscale, capable for multiple integration, advanced data management and analysis), to provide robust information and quality control on the nanomaterial properties and products quality, reliable manufacturing, without affecting the process. Objectives:O1. Develop rapid and real-time nanoscale, multi- modal & scale characterization tools/methodologies for OEs O2. Integrate the non-destructive nano-characterization tools in in-line R2R printing and OVPD PPLsO3. Develop characterization Protocols and Data Management for interoperability across industriesO4. Demonstrate the tools in industrial OE processes for improvement of quality and reliability of products O5. Validation of OE product quality and manufacturability on commercial applicationsO6. Effective Transfer of results to industry by Open Innovation (Dissemination, Training, Networking/Clustering) and ManagementRealNano will revolutionize industrial manufacturing by strongly improving the speed of the characterization procedures in terms of performance (non-destructive with nm-scale resolution in ms time) and reliability (measure/analyze OE nanol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RANGE – Recombination And geNomic architecture in Genomic Erosion' under Horizon Europe.

assistant: **Concept**

Understanding how threatened populations lose genetic diversity is a fundamental challenge in evolutionary biology and conservation. Genomic erosion—the loss of diversity and accumulation of harmful mutations—reduces adaptive potential, drives inbreeding depression, and increases extinction risk. Yet, we still lack predictive models of how erosion unfolds across the genome during population decline. In RANGE, my aim is to test how recombination landscapes and genome architecture shape genomic erosion, moving beyond genome-wide averages to reveal fine-scale rules that govern genetic diversity loss. The project combines three components: (i) Develop genomic resources by building high-resolution recombination maps, analysing high-quality reference genomes, and reconstructing founder haplotypes in four endangered bird species with exceptional temporal and pedigree data. (ii) Explain patterns of genomic erosion by tracking haplotype segments through pedigrees and applying simulations to disentangle the contributions of recombination, drift, and gene conversion. (iii) Establish a predictive framework that integrates empirical patterns with forward-time models (SLiM) to generalise findings across genomes and species. By explicitly incorporating recombination landscapes into temporal genomic analyses, RANGE will, for the first time, test whether genomic features can predict the locations and patterns of load accumulation in threatened birds. This integration of evolutionary theory, high-quality temporal genomics, and conservation will transform our understanding of genomic erosion, delivering conceptual advances and practical insights into how genome architecture shapes diversity in small populations.


**Keywords:** Evolutionary Genomics; Population Genetics; Conservation Geno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Geometry and Anomalous Dynamic Growth of Elastic instabiliTies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Elastic instabilities are ubiquitous, from the wrinkles that form on skin to the ‘snap-through’ of an umbrella on a windy day. The complex patterns such instabilities make, and the great speed with which they develop, have led to a host of technological and scientific applications. However, recent experiments have revealed significant gaps in our theoretical understanding of such instabilities, particularly in the roles played by geometry and dynamics. I will establish a group to develop and validate a theoretical framework within which these results can be understood. Central to my approach is an appreciation of the crucial role of geometry in the pattern formation and dynamics of elastic instabilities.As a starting point, I will consider the model problem of a pressurized elastic shell subject to a geometrically large deformation. This system develops either wrinkles or a stress-focusing instability depending on the internal pressure. As such, this is a natural paradigm with which to understand geometrical features of deformation relevant across length scales from deformed viruses to the subduction zones in Earth’s tectonic plates. My team will combine theoretical and computational approaches with tabletop experiments to determine a new set of shell deformations that are generically observed in contradiction of the classic ‘mirror buckling’. Understanding why these new shapes emerge will transform our perception of shell instabilities and provide new fundamental building blocks with which to model them. These ideas will also be used to transform our understanding of a number of other, previously mysterious, elastic instabilities of practical interest. Turning our focus to the dynamics of instabilities such as the snap-through of shells, we will show that accounting fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering Proteases' (PROTENG) under Sixth Framework.

assistant: **Objectives**

Enzymes find manifold economical applications reflected by a rapidly growing multi-billion dollar market covering industrial sectors from textiles and detergents to pharmaceuticals and the food and feed market. In order to adapt nature's products to industrial processes, one of the challenging tasks of protein engineering is the development of enzymes with new or improved properties. In this context proteases are of outstanding interest.Proteases are nowadays used as one of the main components of detergents and additionally have an enormous potential as highly target-specific pharmaceuticals. With their enzymatic turnover they can catalytically inactivate target proteins thereby acting efficiently in unrivalled low concentrations. c-LEcta has developed proprietary technologies to evolutionary develop and optimize properties of enzymes.With its unrivalled screening technology allowing looking through enzyme libraries with complexities of up to 100 million variants, c-LEcta develops enzyme products to be used as biocatalysts in chemical synthesis and as tools in molecular biology research. The screening technology of c-LEcta will be adapted to the enzyme class of proteases allowing c-LEcta to address the above mentioned markets. c-LEcta will enter the enzyme engineering market for the development of improved proteases for the detergent market and will establish the requirements to address the challenge of evolving highly sequence specific proteases as pharmaceutical drug candidates.Two experienced researcher from the protease field will be integrated into c-LEcta's lab staff for 2.5 years with the aim of establishing the adaptation of the technology and realizing the proof of principle for the technology application for at least two examples. These researchers will work c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Monomode Surface Emitting Lasers' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Vertical cavity surface emitting lasers (VCSELs) have several particular advantages over the edge emitting lasers (EEL) for replacing them in optical communications applications, as the possibility of wafer-level testing during the fabrication process as well as facilitated optical coupling and overall module packaging. Nevertheless, several major improvements should be brought to the existing VCSELs before they become widely used in high speed optical datacom links. Among existing limitations, a limited power delivered by high speed (10 Gbit/s and up) transversely monomode VCSELs. This limitation is a key issue for the introduction of VCSELs in FTTx devices, especially in Passive Optical Networks where the power launched into the fiber must be rather high. Hence, mode size and polarization control are key issues in design of high performance VCSELs. Introducing elements of photonic crystal is an efficient way to increase the mode size while maintaining or even improving operating characteristics.In the present project, we aim to achieve an overall improvement of the VCSELs performances using micro and nanoscale patterning. The novel cavity configurations explored will allow:to increase the size (and thus the power) of the fundamental transverse mode of the VCSEL;to keep the laser transversely monomode at much larger current ranges;through the latter, to improve the modulation speed of the lasers;to control the polarisation of the emitted beam in temperature range and under modulation.Two general geometrical configurations, patterning of the mirrors and patterning of the cavity close to the active layer will be explored.The objective of the project is to demonstrate a configuration of the vertical cavity that would allow a 10-fold improvement in the monomode powers over
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dihydrofolate reductase-thymidilate synthase - drug target in trypanosoma cruzi' in the context of a Fourth Framework call.

assistant: **Objectives**

Trypanosoma cruzi is the aetiological agent of Chagas' disease and according to WHO, approximately 20 million persons are currently afflicted in South America. Nevertheless, except for a few major findings, the advances in the treatment of Chagas' disease are moderate. Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are targets for chemotherapy, as inhibition of either enzyme results in the death of cells. The applicant will perform extended studies on the bifunctionalTrypanosoma cruzi DHFR-TS and the individual DHFR domain. The first objective will consist in the improvement of the expression system for these proteins in order to initiate crystallization studies for performing drug design. The second main objective of the research project will be extensive mutagenesis of T. cruzi DHFR-TS. Hopefully the identification and exploitation of the clear differences between DHFRs from the parasite and its mammalian host should allow for the development of effective drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Imagine a System and Processing Equipment for deep Etching with a Double Etch Rate' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Assessment of advanced prototype of MEMS (Micro Electro Mechanical Systems) etching tool for deep reactive ion etching of silicon at extremely high etch-rates. The process and hardware limiting factors will be identified and hardware upgrades, which overcome these limits, installed during the course of the project. The goal is to qualify new MEMS etching equipment of at least double the etch rate compared to existing tools and superior performance with respect to other key parameters, like uniformity, profile control, CD-loss (Critical Dimension-loss) of the etched structures, repeatability, MTBF (Meantime between Failure), Up-Time of the equipment and reliability. To achieve this, a prototype-etching tool will be installed at the node site where the assessment is being performed. The equipment supplier is supporting the evaluation work and providing hardware upgrade parts and installation services to the node. Results of the assessment will be immediately transferred to existing production equipment.Objectives:Assessment of advanced prototype for high-rate deep reactive ion etching tool for silicon micromachining. Identification of the limiting factors for process and equipment. Qualification of hardware upgrades to achieve superior etch performance. At least double the etch-rate of existing advanced prototype tool from 4 µm/min to 8 µm/min. Improve uniformity across wafer area by a factor of 2. Improve profile angle off-vertical deviation by a factor of 2. Improve profile form to rectangular bottom type profile. Reduce edge exclusion zone of the wafer from 10 mm to 5 mm by implementation of an electrostatic chuck as substrate holder. Improve items for the equipment like MTBF (meantime between failure), Uptime, Cleaning Cycle Period, Cleaning time, and wafer handling m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Process for the production of microencapsulated micro-organisms for bioremediation', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Bioremediation of soil contaminants by microorganisms is in principle a safe, effective, and economic alternative to traditional methods. Its major practical limitations are that a large amount of viable bacteria is required on demand, and the lag-time between inoculation of the soil, and reaching maximum biological activity. At present, this time is unpredictable and may vary between several hours and weeks. This project seeks to address these limitations by using micro encapsulation, which has not been largely applied in the field of bioremediation before. Micro encapsulation will be used to maintain the activity of the microorganisms, even after long storage, and incorporate growth promoters to speed the process. Micro encapsulation is expensive and the project will seek low cost methods for large-scale production of encapsulated bioremediation agents. Two Sees active in the field of bioremediation originate this proposal.