RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SMART POINT-OF-CARE DEVICE FOR SELF-PATIENT MANAGEMENT OF THE ORAL ANTICOAGULANT THERAPY'.

assistant: **Innovation**

The goal we seek in CoaguPOC project is to develop a “ready to the market” smart point-of-care device for self-patient management of the Oral Anticoagulant Therapy (OAT). OAT is a long-term or even chronic therapy necessary to inhibit the formation of potentially lethal blood clots in patients with high risk of thrombosis; e.g. strokes, the 2nd single largest cause of death in the world. Approximately 2% of the population are prescribed long-term oral anticoagulants, meaning that more than 10-12 million people are treated in Western Europe. OAT therapy needs regular tests to confirm correct dosage levels because the drugs have a narrow therapeutic window and small changes in systemic changes can give rise to adverse toxic effects. Tests are usually made once a month in a nursing service at the hospital or care center. The constant increase on the number of anti-coagulant patients (around 10% annually) is highly intensifying pressure and cost on the healthcare resources required to monitor, prevent and manage adverse events.The use of point-of-care coagulometers at home for self-monitoring may avoid unnecessary visits to hospitals or clinics while permitting more frequent monitoring and timely adjustment of anticoagulant dosing to avoid adverse events. The OAT self-management leads to important reductions on adverse events, as thrombosis (reduction by 50%), major hemorrhages (12%), death (18%) and thrombotic events (67%) as compared to ‘usual care‘. It also has a substantial impact on the quality of life of patients and their families, and important cost savings on the healthcare system. For instance, in UK a mere increase of 5% improved in average therapeutic range, led to a reduction of 550 strokes per year and associated cost saving of around €12,000 per patient.Coagu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Developing a leading-edge European Micro- and nanoelectronics cluster for energy efficient ICT'.

assistant: **Objectives**

Four of the leading European micro- and nanoelectronics regions are joining their research, development and production expertise to form the transnational, research-driven cluster “Silicon Europe”.  Involved in this national “triple-helix” consortia are the following high-potential mature clusters: the German Silicon Saxony, centred in Dresden, the Dutch High Tech NL, centred around Eindhoven in the South Eastern part of the Netherlands, France’s Minalogic, centred in Grenoble, and Belgium’s DSP Valley, centred at Leuven.The Silicon Europe partners are linked by a common goal: to make Europe the world’s leading centre for energy efficient electronics – Silicon Europe – The Leaders for Energy Efficient ICT ElectronicsThe involved clusters in total have nearly 800 members , most of them (more than 75%) are SMEs, and count for more than 150.000 jobs (covering  thereby more than 60% of the respective jobs in Europe) . They combine highly relevant research actors such as imec, CEA-Leti and Fraunhofer as well as large companies such as Philips, NXP, Globalfoundries, Infineon, STMicroelectronics and Thales. All involved clusters cover the full triple helix.Within Silicon Europe, following an in-depth analysis, joint action plans will be developed for concerted research in the field including the development of regional smart specialisation strategies and a internationalisation strategy for the involved clusters.Silicon Europe has as its ambition to place Europe in a leading position in research and development for the key enabling technology of Micro- and Nanoelectronics by using the full potential of synergy and complementarities of the existing high-potential clusters in France, Germany, Belgium and the Netherlands and potentially other  European clusters. The extension of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Low Cost and High Efficiency CO2 Mobile Air Conditioning system for lower segment cars'.

assistant: **Innovation**

The Project objective is the development of a low cost and high efficiency air-conditioning system based on CO2 (R744) as refrigerant fluid. Methods to assess performance, fuel annual consumption and environmental impact will be identified and they will constitute a first step for EU new standards. The EU, as Greenhouse Gas emission reduction measure, proposed the ban for Mobile Air Conditioning systems of fluids having a Global Warming Potential lower than 50 (i.e. R-134a and R-152a) with complementary measures - e.g. measurement of the MAC fuel consumption - This represents a challenge and an opportunity for OEMs and Mobile A/C Suppliers. The CO2 - R-744 when used as a refrigerant - is the favourite candidate to replace the R-134a. Besides safety, reliability and efficiency, the present estimated additional cost, ranging from 70 up to 150 Euro with reference to the low priced car systems, represents a obstacle. The lower priced vehicles constitute up the 70% of the present EU car market, this number will rise up to the 80% with the EU enlargement. A low cost and high efficiency R 744 MAC will support the EU efforts reducing the resistance to the approval of the HFC ban, allowing a rapid diffusion of the new system with the related environmental benefits and making the EU industries more competitive. The consortium composition - 2 major OEMs, 4 suppliers and three acknowledged excellence centres - makes the risk acceptable assuring an effective exploitation. Finally the Project gathers the most skilled European scientists and engineers in this specific field, so high level scientific and technical know how are expected to be produced as well as scientific advances in the dynamic system modelling. This will contribute to strengthen EU industries position in other domain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Beyond the Protein: Manipulating Proteoforms with Chemical Tools'.

assistant: **Objectives**

The human body can synthesize ~70’000 different proteins. These proteins diversify into millions of proteoforms, e.g., by associating into complexes or acquiring functionalities called post-translational modifications (PTMs). Distinct proteoforms are often found in different cell types and have diverse functions. Dysregulation of specific proteoforms is associated with many diseases, including neurodegeneration or cancers, highlighting the need for their study and modulation. Despite these needs, most drug-like molecules are designed to indiscriminately activate, inhibit, or destroy a target protein—they are blind to the localization or function of different proteoforms.PROTEOFORMER goes beyond the protein by developing chemical tools for manipulating specific protein forms. In two parallel initiatives, PROTEOFORMER will:(1) Target a specific proteoform of the muscarinic acetylcholine receptor—relevant to Parkinson’s disease treatment—dissecting its function and laying the groundwork for new therapies.(2) Modify post-translational modifications of matrix metalloproteinase-2—a key regulator of neuroinflammation—aiming to unravel their so-far-elusive function.PROTEOFORMER offers tailored reagents that (i) recognize the protein target, (ii) bring a reactive group to the target’s surface, and (iii) attach molecular cargo to the protein via a proximity-induced reaction. It rethinks this ‘ligand-directed chemistry’ by introducing functional, proteoform-manipulating cargo:(1) A blocker of a partner protein, enabling proteoform-selective inhibition within a cell-specific complex.(2) A post-translational modification or its eraser, enabling on-demand switching between proteoforms with newly developed proximity-driven chemical reactions.PROTEOFORMER develops new chemistry for man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Analysis of speciation modes in plant RNA viruses' under Seventh Framework.

assistant: **Concept**

Viruses are one of the most important groups of parasites affecting human and animal health, and crop production, and they make a large fraction of emerging diseases. A key characteristic of viruses is their high potential to generate genetic diversity. This characteristic provides viruses with a high capacity for adaptation to new environments, including new hosts. Adaptation to new host genotypes or species may lead to the appearance of new viral lineages or species: that is, to ‘speciation’ events. This process may result in the emergence of new viral diseases, and compromise existing disease control strategies. Therefore, understanding virus speciation may be of deep social and agronomical significance as it may provide the cues to predict and control viral disease epidemics.Despite the relevance of virus speciation to understand disease dynamics, little is known about how it happens and which are its driving factors, especially for plant viruses. This project will analyse the modes and ecological determinants of plant virus speciation. Specifically, my research will focus on the species of the genus Potyvirus infecting natural populations of Arabidopsis thaliana, and accompanying annual plant species. To address the objectives of this project, I will collect field data on potyviruses population genetic structure and epidemiology, as well as on host species ecological traits. I will analyse these data by combining molecular biology techniques with advanced statistic and state-of-the-art bioinformatics tools. The results of this work will be used to build a predictive model of virus emergence integrating the genetic, ecological and epidemiological data collected.The results of this research may help to understand the origin of the emergence of novel viral diseases, h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Assessing the role of ribosomes and mRNA translation in shaping the inflammatory response' (RiboInflam).

assistant: **Concept**

Inflammation is a highly regulated process that acts as a first line of defense against pathogens infections. Triggered by cellular pattern recognition receptors (PRRs) that recognize specific microbial components and endogenous or exogenous non-microbial components, activation of inflammation induces a dynamic and coordinated gene expression program that leads to the production of cytokines and chemokines to attract effector cells to the site of infection. Although a robust inflammatory response is required for efficient clearance of pathogens, uncontrolled or prolonged inflammation can lead to inflammatory disorders such as septic shocks or to autoimmune diseases like lupus. Most studies have focused so far on the transcriptional control of the inflammatory gene expression program. However, post-transcriptional regulatory mechanisms involving mRNA splicing, mRNA decay or translation have also been described to control the inflammatory response. Among these, regulation of mRNA translation allows for rapid and reversible modulation of gene expression but its precise role and control mechanisms in the inflammatory response remain poorly understood.Using innovative technologies, our project aims at characterizing the role of ribosomes and mRNA translation in regulating the inflammatory response. In particular, we propose to identify the complete set of of ribosome accessory proteins and to determine their role in the context of “specialized ribosomes” with specific regulatory activities. We will also study the cross-talks between ribosomes and other cellular processes such as mRNA decay and uncover the role of mRNA editing in regulating translation during the inflammatory response. From this work, we expect to identify new regulatory mechanisms that orchestrate inflammati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Antimicrobial resistance transfer from and between gram-positive bacteria of the digestive tract and consequences for virulence (ARTRADI)'.

assistant: **Concept**

Horizontal gene transfer is one of the main mechanisms facilitating the spread of antibiotic resistance. There is a gap in our knowledge of the extent and rate of prokaryotic gene flux as well as barriers for the expression and maintenance of transferred genes in new hosts. This project will focus on the transfer of glycopeptides, microcline, and tetracycline resistance determinants between Gram-positive bacteria from digestive tract samples from animals and human and food. The study in vitro and in vivo of:(I) the transferability and the stability of resistance determinants;(ii) the link of resistance with virulence;(iii) the detection and characterisation of new resistance determinants;(iv) the ability of food-ingested bacteria to pick up and retransfer resistance determinants will further our knowledge as to how to control the spread of resistance and virulence markers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cost Reduction and market Acceleration for Viable nearly zero-Energy buildings' (CRAVEzero), addressing dissemination and exploitation.

assistant: **Impact**

Cost optimal and nearly zero energy performance levels are principles initiated by the European Union’s (EU) Energy Performance of Buildings Directive, which was recast in 2010. These will be major drivers in the construction sector in the next few years, because all new buildings in the EU from 2021 onwards are expected to be nearly zero energy buildings (NZEB).While realized NZEB have clearly shown that nearly-zero energy target could be achieved using existing technologies and practices, most experts agree that a broad scale shift towards nearly-zero energy buildings require significant adjustments to prevailing building market structures. Cost-effective integration of efficient solution sets and renewable energy systems, in a form that fits with the development, manufacturing and construction industry processes, as well as with planning, design, and procurement procedures, are the major challenges. CRAVEzero will focus on proven and new approaches to cost reduction of  Nearly Zero Energy Buildings (NZEBs) at all stages of the life cycle. The main goal is to identify and eliminate the extra-costs for NZEBs related to processes, technologies, building operation, and to promote innovative business models taking into account the cost-effectiveness for all the stakeholders.Main project pillars will be: (i) CRAVEzero pinboard as a structured framework organizing all needed information and data to build an effective low life cycle cost NZEB business model (ii) reliable lifecycle cost databases with cost reduction potentials in processes and technologies (iii) methodologies, robust solutions and business models for low LCC NZEBs. Costs reduction will indeed cover all stages of the process, from urban planning, to building design, construction, until the building operation,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Gender and migration, globalisation of domestic work: the Moldovian case in Turkey' to be submitted under Sixth Framework.

assistant: **Abstract**

The project is designed to investigate the new trends of globalisation of domestic work in the Turkish context by focusing on Moldovian women migrants. The main aim is to gain a comprehensive analysis of gender and migration in the new trends of international migration. In order to reach this main aim, three objectives will guide the research. First to investigate in detail and analyse the dynamics of migration flows from Moldova to Turkey. Secondly, to explore the gender dimension of migration in the Turkish context. Thirdly, to compare the Turkish case with the European Union countries and to carry the Turkish experience to the EU, in the wider context of globalisation of domestic work.By depending on case studies, mostly from Europe, there will be a discussion on the peculiarity and commonality of the Turkish case. The strong relation between informal economy and irregular migration will be evaluated and its impact on globalisation of domestic labour will be investigated. There is an extensive literature on Turkish migration experience as a sending country. However, since the Turkish experience on international migration as a receiving country is relatively new; there is only limited research on irregular migration in general and gender dimension of the new migratory flows in particular. For this sake, there is a need to obtain information and knowledge of the newly emerging trends. Since Turkey is a candidate of the European Union and since its geographical position, the Turkish experience will be of great importance for the EU. Therefore migration to and through Turkey deserves detailed analysis.The growing trends of irregular migration coincide with the Turkey's membership to the European Union as a candidate country and the process of adapting its own legal and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assessment of Cross(X)-sectoral climate Impacts and pathways for Sustainable transformation' (AXIS) targeting Horizon 2020.

assistant: **Abstract**

The AXIS consortium is set up to enhance integration of an array of research disciplines connected to climate research around the common goal to enhance the assessment of potential impacts of climate change on the bio-physical systems and human society. To this end AXIS plans to launch and implement a single transnational call – funded by 11 European research funders. Through an open process AXIS has developed three topics for this call. Each topic is intended to enhance collaboration across typical community borders: between different sectoral views of climate impacts as well as between bio-physical climate impacts and socio-economic effects. For all topics stakeholder engagement is given a high relevance in the call, thus representing another dimension of interaction across boundaries: interaction of the science community with end-users (stakeholders) of the created knowledge (transdisciplinarity). The three anticipated research areas (topics) are: (1) Cross-sectoral and cross-scale climate change impact assessments; (2) Integration of biophysical climate change impacts estimates with economic models; (3) Developing pathways to achieve the long-term objectives of the Paris Agreement, taking into account interactions with SDGs closely linked to SDG 13 (“climate action”). The AXIS consortium is deeply embedded in JPI Climate and aims to implement elements of its Strategic Research & Innovation Agenda. JPI Climate and the ERA-NET promoting Climate Services ERA4CS include a number of additional activities. Therefore within this proposal no addition activities are planned.Close partnership of the AXIS consortium and JPI Climate with other key international initiatives (Belmont Forum, GFCS, Future Earth, UN PROVIA, Copernicus) will be sought in order to continue to work aga