RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovations and impact of gut health foods: a virtual technology platform' (GUTIMPACT).

assistant: **Innovation**

The SSA GutImpact will build on previous FP5&6 activities [5] and identify and prioritize these knowledge gaps, provide avenues for bridging these, and prepare the technology roadmaps for future European public-private interactions aiemed at addressing the molecular mechanisms by which functional microbes and ingredients affect human gut health. This will allow for coordination of the rational development, targeted improvement, and safe production of these food in interest of the European consumer. All these activities contribute towards product innovation and cost-effectiveness of the European food and biotechnology industries, including SMEs. This ensures that the European consumer will ultimately benefit not only during the period of the SSA but also well beyond it. This will be achieved by realising the following three main objectives: 1. Create a dialogue on scientific needs and support of health claims between a wide audience of stakeholders and end-users, including academic and industrial scientists, competent authorities, and consumer organizations; 2. Reach consensus on reasearch priorities between academic and industrial scientists, consumer organizations; 3. Establish a technology roadmap for public-private research and consumer interactions on health impact foods. The SSA GutImpact targets the following four different groups of stakeholders and end-users: * Academic and industrial scientists who are the start of the science push of the food innovation cycle. * National and EU funding agencies that are instrumental in at the one hand providing a knowledge base but at the other hand fostering public-private interactions. * A variety of authorities dealing with regulatory and claims issues, including the European Food Safety Authority, World Health Organization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'from Cubic To Linear complexity in computational electromagnetics' (321) targeting Horizon 2020.

assistant: **Abstract**

Computational Electromagnetics (CEM) is the scientific field at the origin of all new modeling and simulation tools required by the constantly arising design challenges of emerging and future technologies in applied electromagnetics. As in many other technological fields, however, the trend in all emerging technologies in electromagnetic engineering is going towards miniaturized, higher density and multi-scale scenarios. Computationally speaking this translates in the steep increase of the number of degrees of freedom. Given that the design cost (the cost of a multi-right-hand side problem dominated by matrix inversion) can scale as badly as cubically with these degrees of freedom, this fact, as pointed out by many, will sensibly compromise the practical impact of CEM on future and emerging technologies. For this reason, the CEM scientific community has been looking for years for a FFT-like paradigm shift: a dynamic fast direct solver providing a design cost that would scale only linearly with the degrees of freedom. Such a fast solver is considered today a Holy Grail of the discipline.The Grand Challenge of 321 will be to tackle this Holy Grail in Computational Electromagnetics by investigating a dynamic Fast Direct Solver for Maxwell Problems that would run in a linear-instead-of-cubic complexity for an arbitrary number and configuration of degrees of freedom. The failure of all previous attempts will be overcome by a game-changing transformation of the CEM classical problem that will leverage on a recent breakthrough  of the PI. Starting from this, the project will investigate an entire new paradigm for impacting algorithms to achieve this grand challenge. The impact of the FFT’s quadratic-to-linear paradigm shift shows how computational complexity reductions can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Supporting interactive multimedia on-line services' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objective of the proposed WG is thus to acquire a better understanding of the actual problems and limitations of the current technologies and methodologies which prevent an easy and cost effective development of multimedia interactive applications and to contribute to their solution. The long term aim is to contribute to the development of multimedia interactive application frameworks within which tools, techniques, and methodologies can be efficiently integrated. To achieve this objective the WG will coordinate the research activities of the partners in the following areas: (i) database technology evolution, (ii) on-line services interoperability, (iii) design methods and tools, (iv) tools integration and adaptation.A close and profitable co-operation between the partners will be achived through the exchange of information and personnel, short visits, as well as the organization of well defined thematic workshops. The partners have been chosen so as to guarantee a balanced presence of academics and industrial representatives as well as the complementarity of skills and experiences.Industrial and commercial exploitation of interactive multimedia on-line services is fast becoming a reality. However, further research should help to overcome current obstacles to the efficient and cost-effective development of large scale applications and should also provide new industrial opportunities. The WG aims at providing a tangible contribution by addressing the above four key research areas in the digital libraries field.At the present and at least for the near future certain multimedia information services will still be distributed on physical media. However, centralized services accessed over a network are now gaining rapidly in popularity and diffusion. Such services have ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel Nanobiosensors for Identifying Microorganisms Using Magnetic Relaxation Switches' in the context of a Seventh Framework call.

assistant: **Objectives**

The goal of this proposal is the development of a totally new type of reagent/instrumentation system based on a Nanobiosensor that Prof. Josephson and Prof. Weissleder have developed and termed “magnetic relaxation switches” (MRS). We propose to apply MRS for two different objectives: 1) detection of microorganisms through their specific sequences on their rRNA (outgoing phase); 2) identification of specific tumoral cells lines using MRS functionalized with specific lectins (return phase).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cell-Cell Communication by Mitochondrial Intercellular Traffic' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Mitochondrial research has consistently yielded surprising discoveries, such as the presence of their own DNA, use of a distinct genetic code, and their role in apoptosis. Recently, the proposal of intracellular mitochondrial transfer (ICMT) in vivo has sparked considerable interest, as this process is believed to hold significant therapeutic potential. This has generated growing public and private economical and scientific effort aimed at exploring ICMT as a potential treatment for common and rare diseases (ischemic reperfusion injury in heart, brain, kidney, etc.; mitochondrial diseases; delay in aging among others). However, there are still significant lack of knowledge, particularly regarding the proposed cellular mechanism of action, with insufficient experimental validation. Additionally, there are no studies on the physiological consequences, modulation, and functional roles of ICTM. A largely overlooked aspect is that mitochondria contain their own DNA. Therefore, if biogenetically competent mtDNA is transmitted by ICTM, the recipient cell become genetically modified. Such phenomenon has so far only been demonstrated in cancer. Therefore, any treatment with mitochondria could be classified as a form of genetic therapy. MINTRAF will establish a new strategy to determine the existence, extent and physiological relevance of ICMT. It will also investigate the maintenance of mtDNA biogenetic competence and the context where this process occurs. To achieve this, we will exploit our unique conplastic and heteroplasmic animal models to: (1) determine the extent, relevance and physiological impact of intercellular mitochondrial transfer; (2) decipher the role of ICMT as signalling process in tumour context; and (3) assess the extent, relevance and physiological impact of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Se-speciation in real world food matrices: identification and the follow-up of the fate of Se-species in functional foods', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The goal of this project is to develop qualitative and quantitative screening methods to identify and follow the fate of Se-species in Se-enriched functional foods. The interest behind the choice of selenium is driven by the state-of-the-art theoretical knowledge on its direct and indirect effects on cancer prevention that strongly depend on the given Se-species acting in in-vitro studies or in human metabolism.Unfortunately, the actual distribution of Se-species in real world matrices is hardly known. The analysis of Se-containing or Se-enriched functional foods, a well-promoted part of innovative food products gives the possibility to analyse samples with challenging matrices and to characterise the Se-species that are putatively active in cancer prevention.Among its main objectives the project includes the- unambiguous identification of Se-species and their possible degradation products by the means of time-of-flight and hybrid triple quadrupole/linear ion trap mass spectrometry through accurate mass measurements and tandem MSn fragmentation studies,- quantification of the Se-species by inductively coupled plasma mass spectrometer (ICP-MS) equipped with a collision cell,- the synthesis of new Se-peptides for the quality control of sample preparation steps,- time-resolved qualitative and quantitative monitoring of Se-species in selected functional food samples, ending up in the form of a database on the Se-species monitored.An elegant method to detect and possibly identify all Se-species extracted from the samples will be the subsequent hyphenation of capillary flow HPLC separation based on reversed phase (RP) or hydrophilic interaction (HILIC) mechanisms to ICP-MS and to organic MS instrumentation.The project will provide the possibility f or me to fully disseminate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genomics and metagenomics of bacterial endosymbionts of pest insect' in the context of a Seventh Framework call.

assistant: **Objectives**

General objective of the research project is the genomic and where applicable metagenomic analysis of novel, recently emerged or in the coming years emerging data on genome sequences of diverse bacterial insect endosymbionts. These organisms include especially the endosymbiont Blattabacterium sp. of the cockroach Blattella germanica, primary and secondary endosymbionts of the silver leaf whitefly Bemisia tabaci (primary esb: ""Candidatus Portiera aleyrodidarum"", secondary esbs: ""Candidatus Hamiltonella defensa"", and Arsenophonus sp.) and the endosymbiont ""Candidatus Erwinia dacicola"" of the olive fly Bactrocera oleae In all cases, the endosymbionts are intricately linked to the respective host and the kind of symbiosis is a mutually obligate one.  However, knowledge on the nature of the symbiosis and the functional constraints between the two partners is in all these cases rather scarce. The function of the endosymbionts for the host is not (completely) revealed yet.  An emerging whole sequence of the reduced genome of the endosymbiont of Blattella germanica, the first one of a non-proteobacterial insect endosymbiont will provide the opportunity for a comprehensive and comparative genomic analysis. Similarly, in the near future sequence data for the whitefly endosymbionts, obtained in a metagenomic approach, will be accessible for our research group. For Cand. E. dacicola we pursue an own medium-sized metagenomic sequencing project to obtain representative data. In the frame of the project genomic and metagenomic studies using bioinformatic tools via comparative analysis will be performed: gene annotation, study of present cellular functions (metabolic routes, regulatory capacity), deduction of the role(s) in the respective symbiosis. In this way, the functional co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Navigating the evolutionary routes of influenza viruses' under Horizon 2020.

assistant: **Concept**

Seasonal influenza viruses re-infect us repeatedly, escaping antibody recognition, due to the evolution of the virus itself. Being able to predict when and how the virus will evolve would be transformative for influenza virus control. Problematically, we have only observed one of the likely many possible routes of virus evolution. We do not know how many viable routes may have existed or about the repeatability of the observed evolution. These knowledge gaps limit the predictability of influenza virus evolution. NaviFlu will fill these gaps by rigorously assessing the repeatability of influenza virus evolution and the diversity of routes the virus can explore.Recent work has shown that prolonged influenza virus infections can result in substantial virus evolution and occasionally portend virus mutational patterns on a global scale. However, observing large numbers of such infections is challenging. We will use an innovative ex-vivo human airway epithelium culture system to artificially create and study prolonged human infections. Together with cutting-edge next generation sequencing and new analysis tools, we will quantify the evolutionary landscape of seasonal influenza viruses.The project has three objectives, each building in complexity: 1–Quantify the evolutionary dynamics of seasonal influenza viruses in the absence of antibody-mediated selection. 2–Determine how the antibody complexity of immune sera shape the evolutionary trajectories of virus antigenic evolution.3–Quantify the impact of differences in selection pressures by site of infection and underlying host variation on virus evolution.Through these objectives we will “play evolution forwards”, revealing the relative roles of different factors governing the mode and tempo of influenza virus evolution and qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chromatin Mediators of Estrogen Receptor Biology' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Estrogen Receptor (ER) drives proliferation in breast cancers and drugs such as tamoxifen and Aromatase Inhibitors, that target ER activity, are first line treatments in clinical practice. However drug resistance is a significant clinical problem. My laboratory has reported that chromatin-modifying pioneer factors are required for ER to bind the genome, and may constitute a unique opportunity for treating drug resistant cancer. My proposal consists of two complementary approaches to comprehensively explore how Estrogen Receptor interacts with these factors to direct transcription. (1) We will demonstrate that FoxA1 and the Groucho protein TLE1 are critical mediators of ER-chromatin interactions by mapping TLE1 binding sites on a genome-wide basis, and functionally testing the roles these factors play with ER in genomic remodeling, gene transcription, cell proliferation, and endocrine resistance. (2) More globally, to characterise ER transcriptional partners on a molecular basis, we will identify the complete complement of ER-associated proteins using novel proteomic approaches. Taken together, these approaches will explore how ER employs pioneer factors mechanistically, and will identify other potential players.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Consumption Work and Societal Divisions of Labour' (DIVLAB) targeting Seventh Framework.

assistant: **Abstract**

Contemporary global developments in work and employment are transforming labour and reshaping relations between workers, creating new webs of interconnection across the world. This research programme aims to radically revise the foundational concept of the division of labour , by situating traditional understandings of the technical allocation of tasks within an expanded theoretical framework. Two additional dimensions of differentiation and interdependency of work activities are proposed, namely across socio-economic modes (market, non-market, etc.) and across the economic processes of production, distribution, exchange, and preparation for consumption. The approach will be developed by opening up a new research terrain of consumption work : all work undertaken by consumers necessary for the purchase, use, re-use and disposal of consumption goods. The work of consumers is shaped by its interdependency with that of providers, and vice versa, so providing a key to route to understanding the overall dynamics and variety of changing worlds of work. Three contrasting empirical probes are chosen for the questions each raises about consumption work and its increasing socio-economic importance: domestic broadband installation, food preparation and household recycling of waste. Analysis will centre for each on the varying nature of the interface and interaction between consumption work and systems of provision in five comparator countries (UK, Sweden, France, Taiwan, Korea) selected for their contrasting socio-economies. The research programme is global, comparative and historical, making a significant scientific and policy contribution, by advancing comprehension of key processes of ongoing socio-economic change, and establishing consumption work as a new field of enquiry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pollution Surveillance and Control in Wetland Ecosystems'.

assistant: **Innovation**

The proposed EU Water Framework Directive in particular requires Member States to prevent any further deterioration of all surface (and ground) waters and to achieve good status in all surface and ground water bodies within 15 years (except for justified specific local cases where the deadline is extended). The Directive also emphasise the use of a global ecosystem approach at the catchment level, especially in the case of transboundary rivers. In order to comply with the new Directive, common definitions of the status of water should be established; reference surface water bodies should be found; methods should be established for monitoring of the ecological and chemical status of surface waters.Also, strategies have to be prepared against pollution, including risk assessments (most of them are already carried out under Council Regulation (EEC) No 793/93. The main objective of the proposed course is to put together such methods, which can be used for assessing the chemical or ecological quality of wetland ecosystems and are in harmony with this new Directive. Many of the methods being demonstrated are widely used in the scientific community, especially for biomonitoring purposes, but they have not been part of any legislation concerning water quality assessment. Water quality is an interdisciplinary issue, especially in wetlands, where sediment plays an important role in ecosystem functioning. Another objective is to bring together experts working in water quality assessment, creating a common platform of understanding.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00423-1.pdf