RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regulation of cryptic splice sites in neuronal differentiation and disease' under Seventh Framework.

assistant: **Concept**

A recent era of RNA research discovered complex RNA regulatory networks that involve RNA binding proteins (RBPs) and RNA. These networks are particularly dynamic and complex in the central nervous system, and can lead to neurologic diseases if deregulated. The host lab studies the regulatory networks that control alternative splicing in the brain. Recently, the lab identified thousands of cryptic splice sites that are bound by the spliceosome, but do not lead to active splicing in the adult brain. In the present project, I will assess if splicing at some of these cryptic sites is regulated during brain development or disease. Moreover, I will determine the importance of such regulation for neuronal differentiation.Most of the cryptic splice sites are present within long introns of genes that are only expressed in the brain. Therefore, I will employ genome-wide experimental and computational methods to study the regulation of cryptic splice sites in mouse embryonic stem cells (mESCs) and mouse brain from several developmental stages.  It is known that binding of RBPs to target pre-mRNAs can actively repress cryptic splicing, which ensures expression of stable mRNAs. FUS and TDP-43 are two RBPs that regulate alternative splicing and lead to amyotrophic lateral sclerosis (ALS) when mutated. They have increased binding to the long introns and their depletion leads to decreased expression of long genes. I will therefore assess changes in splicing at cryptic sites upon depletion of FUS or TDP-43 in mESCs, in ALS mouse models, and in induced pluripotent stem cells (iPSCs) from ALS patients. Since de-repression of cryptic splice sites would lead to aberrant mRNAs, this may unravel the mechanism explaining how FUS and/or TDP-43 regulate the expression of long genes.The study of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computational Propaganda: Investigating the Impact of Algorithms and Bots on Political Discourse in Europe' (COMPROP).

assistant: **Concept**

Social media can have an impressive impact on civic engagement and political discourse. Yet increasingly we find political actors using digital media and automated scripts for social control. Computational propaganda—through bots, botnets, and algorithms—has become one of the most concerning impacts of technology innovation. Unfortunately, bot identification and impact analysis are among the most difficult research challenges facing the social and computer sciences.COMPROP objectives are to advance a) rigorous social and computer science on bot use, b) critical theory on digital manipulation and political outcomes, c) our understanding of how social media propaganda impacts social movement organization and vitality. This project will innovate through i) “real-time” social and information science actively disseminated to journalists, researchers, policy experts and the interested public, ii) the first detailed data set of political bot activity, iii) deepened expertise through cultivation of a regional expert network able to detect bots and their impact in Europe.COMPROP will achieve this through multi-method and reflexive work packages: 1) international qualitative fieldwork with teams of bot makers and computer scientists working to detect bots; 2a) construction of an original event data set of incidents of political bot use and 2b) treatment of the data set with fuzzy set and traditional statistics; 3) computational theory for detecting political bots and 4) a sustained dissemination strategy. This project will employ state-of-the-art “network ethnography” techniques, use the latest fuzzy set / qualitative comparative statistics, and advance computational theory on bot detection via cutting-edge algorithmic work enhanced by new crowd-sourcing techniques.Political bots
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Garlic and health; the development of high quality garlic and its influence on biomarkers of artherosclerosis and cancer in humans for disease prevention' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The product of garlic (Allium sativum L) in Europe is concentrated in Mediterranean countries, Spain, France and Italy. The price of European garlic is high, especially in comparison with Chinese garlic. This price deference could severely threaten the European garlic growers if there was a free market in Europe for garlic. However, to protect the European garlic growers the European Commision issued in 1993 a regulation that only 12000 tons of Chinese garlic can be imported annually. The aim of the plant part of this project is to develop methods, through improved seed technology and genetics, which will enable the European garlic growers to meet the internal demand for high quality products and to compete on the international level. Cancer and cardiovascular diseases are by far the leading causes of death and morbidity in the EU. The health cost spent on the treatment of these diseases reaches many billion EURO. Garlic has been used for a long time as a food with many therapeutic effects. Its beneficial effects are directly linked to its sulphur metabolic. Detailed studies on the mechanism underlying cancer and cardio-vascular diseases are lacking and especially studies with defined garlic preparations and compounds are poorly found. Therefore in this project we will focus on the role of garlic for the prevention of chronic diseases like atherosclerosis and cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Three Generations of Digital Human Rights' (DigitalHRGeneration3).

assistant: **Concept**

The proposed research program explores different strategies developed in the digital age within and outside international human rights law to respond to new needs, interests, risks and challenges brought about by transition of inter-personal interactions, social activities and regulatory schemes from offline to online environments. It investigates the development in recent years of three generations of digital human rights: adaptation of existing rights and their manner of application to online environments (e.g., online privacy), the creation of new digital rights (e.g., right to access the Internet) and the introduction of new rights and duty holders (e.g., virtual persons and online platforms exercising quasi-sovereign power), as well as the development of alternative protection avenues based on private ordering, including rights by design and community standards, Internet governance and multi-stakeholder arrangements. The ERC project will examine these paradigmatic normative, institutional and theoretical developments, and the policy choices behind them from five methodological perspectives: (1) historical study of the evolution of digital human rights and of choices made by norm-entrepreneurs and law-makers between different  protection frameworks; (2) analytical study of protection gaps, overlaps and conflicts across traditional and digital human rights and alternative arrangements; (3) comparative study juxtaposing developments in the field of digital human rights against analogous development in international human rights law, with a view to identifying paradigms of normative and institutional change; (4) empirical analysis through interviews of the perceived effectiveness and legitimacy in the eyes of stakeholders of the said developments ; (5) Evaluation of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role Of T Cell activation in type 1 diabetes; T cell differentiation versus T cell tolerance' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The proposal presented here represents a continuation of the work I have done in the USA on<p>T lymphocyte peripheral tolerance and autoimmune diabetes. My goal is to gain a better<p>understanding of the disregulation of the mechanisms of immune tolerance leading to the activation of<p>autoreactive T cells in autoimmune processes. This will allow us to rationally design new therapeutic<p>strategies against type 1 diabetes in particular that can prevent or stop the progression of the disease<p>before insulin function is lost. These forms of therapy are inexistent at the present time.<p>The interplay among three types of cells plays an important role in the onset of type 1 diabetes.<p>These are CD8+ T cells, CD4+ T helper cells and antigen presenting cells (APCs). In a normal<p>situation, tolerogenic APCs will pick and transport self-antigens from the parenchyma to the draining<p>lymph nodes where they will silence CD8+ and CD4+ T cells. If CD4+ T cell tolerance fails, CD4+<p>helper cells will activate APCs that in turn will promote the differentiation of potentially autoreactive<p>CD8+ T cells into diabetogenic killer cells. Based on this hypothesis, the aim of this project is to<p>decipher the cellular and molecular interactions responsible for the establishment of T cell tolerance to<p>pancreatic antigens and the activation of potentially autoreactive T cells leading to autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reslient Rapid ReconfiGurable pROdUction Process chains', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Covid-19 has shown that unpredictable events can disrupt supply chains, demand, and induce work restrictions, which can be detrimental to the manufacturing sector, significantly affecting growth. Especially, when medium or high-volume manufacturing is considered, resilience can only be achieved through rapid reconfigurability and digitalization. Rapid reconfigurability must be addressed in all production levels, ranging from the factory to the machinery and to each individual process step, as well as the interaction with the supply chain. The objective of R3GROUP is to develop and demonstrate resilience strategies for reconfiguration. The project will carry out industrial demonstrators in diverse manufacturing sectors (automotive, fabricated metal products, rubber and plastics, wearing apparel, home appliances) facing various reconfiguration issues (scale up or down, introduction of new suppliers, accommodation of multiple product variants, resilience to unforeseen events), engaging end-users operating with different business models (B2B, B2C) and on different positions in the value chain (OEM, Tier 1). R3GROUP will follow the 6 reconfigurability principles to develop technologies in 5 pillars towards resilience through reconfigurability: i) release an AAS-enabled platform for horizontal and vertical integrability for reconfigurability; ii) develop production tools and technologies, through the reconfigurable machine tool concept; iii) deploy a digital toolkit supporting rapid evaluation of reconfiguration impacts, using multi-level digital twins; iv) integrate innovative tools to capture the trigger for reconfiguration that provide awareness on the status of the rest of the value chain (supply chain, market); v) multi-level monitoring, control, and quality assessment t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular surface characterization using microprobes in light gradients' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Laser trapping is emerging as a powerful and promising tool to improve our knowledges in the fields of nanotribology, biophysics and material testing. With 'optical tweezers' we can expose single bonds under load . and test material properties of molecular structures in liquids over a force range centered in piconewtons. For instance, it is possible to study in a very direct way the processes of molecular adhesion between soft interfaces and measure in vivo the forces acting at molecular level in biological systems. Project objectives 1) Development of advanced and flexible optical tweezer systems, a) to obtain high performances in the fields of forces sensoring, force mapping and material testing, b) to test different trapping geometries and configurations. 2) Development of a dedicated software to automatically control, programmeand monitor all the relevant parameters correlated to the trapping system, such laser power, laser focus, fine movements of the trap in 3D-space, sub-nanometer probe positioning-system, image acquisition system. 3) Improvement of an innovative method of surface characterization, based on the measurement of the friction between microprobes held by the laser trap (for example micrometer sized polystiren beads functionalized with chosen molecules) and the sample (cell surface, functionalized thin films, surfaces with special coatings). 4) Applications: mapping of cell receptors to understand the functional significance of tumour-associated cell surface alterations; study of chemical/mechanical properties of artificial membranes and liposomes, characterization of surfaces with special coatings. Training content (objective, benefit and expected impact) From my Ph.D. research project I expect to acquire all the scient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decoding communication between mobile genetic elements' under Horizon Europe.

assistant: **Concept**

Communication between organisms is one of the most sophisticated forms of social interactions. It has been recently discovered that bacterial viruses (phages) show multiple social attributes including the ability to communicate extracellularly with their progenies through a peptide-based system called arbitrium. This system is utilized by phages to guide life-cycle decisions, such as the transitions between their quiescence and virulence states. It has subsequently become clear that this system is not exclusive to phages but is also present in other mobile genetic elements (MGEs) and that its underlying design and function has diversified considerably. Despite the wide-ranging impact of these discoveries, the molecular basis of these new systems of communication, and their function in different MGEs, remain to be deciphered. More importantly, although it has been proposed that phages only communicate with their progeny, our preliminary results indicate that the arbitrium system can be used by phages and other elements to communicate with unrelated MGEs, sometimes present in different bacterial species. However, the prevalence and ecological role of this unprecedented inter-MGE communication is unclear. In the TalkingPhages project, we’ll explore all these questions and establish the molecular basis used by arbitrium systems to shape MGE diversity, interactions amongst MGEs and bacterial ecology and evolution. Our team combines expertise in MGEs and communication systems using tools from genetics (Penadés), biochemistry (Marina) and eco-evolutionary dynamics (Eldar). By exposing the multi-layered network of communications between MGEs, which is amenable for exploration on multiple levels of resolution, this project would set a milestone in understanding the complex eco-e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Solar magnetic field and its influence on solar variability and activity' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

For life on Earth, the Sun is the most important astrophysical object in the universe. For astrophysicists, the atmosphere of the Sun presents an intriguing, complex and extremely varied environment generated by continuous dynamic, small-scale interactions between plasma and intricately structured magnetic fields. The purpose of this proposal is to elucidate the physics underlying the structure and dynamics of the solar magnetic field that is responsible for the Sun’s varied activity and its variability. This goal is to be achieved by following an integral approach combining new observational facilities, novel instruments developed in the group of the PI, the next generation of inversion techniques for data analysis and state-of-the-art magnetohydrodynamic simulations. This wide range of expertise present in the group of the PI is unique and well suited to such an approach. The research proposed here will provide measurements of the Sun’s magnetic field at high spatial and temporal resolution at unprecedented sensitivity to Zeeman splitting and to magnetic flux. Also, the use of a novel polarimetric hyperspectral imager, combined with the next generation of inversion techniques will allow following the 3D structure of the magnetic field and of other physical parameters in time through a sequence of snapshots. This will enable following the build-up of magnetic tension and of waves following the field lines and will set important constraints on the heating mechanism of the solar chromosphere and corona. The proposed work, in particular the comparison of measurements with simulations, will also set constraints on the presence and properties of a small-scale turbulent dynamo as well as other fundamental physical processes taking place in the solar atmosphere. The technique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Human Landscapes: agricultural intensification and peasant resilience in medieval Southern Greater Syria.'.

assistant: **Concept**

Medieval Islamic Archaeology in Southern Greater Syria is relevant to the sustainable agricultural intensification discourse due the implementation of state intensive land use for profit that affected the lives of peasants and the ecology of semi-arid regions. Medieval Islamic agricultural intensification practices included irrigation, fertilizers, overgrazing, deforestation and cash cropping, which increase agricultural yields. The project “Human Landscapes: agricultural intensification and peasant resilience in medieval Southern Greater Syria” (HumanLand), offers a deep-time perspective on these issues. According to surveys and historic resources, the later medieval Islamic eras were marked by the collapse of the Mamluk state, the decline of major agricultural centers, and a shift to a seasonal basis occupation partly due to climatic stressors of the end of the 14th and 15th centuries, as well as the lack of state resources and support. HumanLand will use new environmental and textual data for medieval land-use to investigate these three objectives: 1) To identify changes in agricultural intensification in relation to climatic, political and economic shifts that took place in the late 14th and much of the 15th centuries, 2) To investigate the use of sustainable strategies and impact of imperial regimes on medieval communities, and 3) To investigate the impact of political structures on the ecology in semi-arid regions. The project will use botanical micro remains (phytolith, starches and spherulites) and stable isotope data from crop remains to understand agricultural practices of six medieval communities of Jordan and Israel. This evidence will be evaluated with information on land-use in medieval texts. These methods combined, provide evidence for intensified agricu