RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'ICT Roadmap and Data Interoperability for Energy Systems in Smart Cities'.

assistant: **Concept**

READY4SmartCities operates in a European context where other initiatives are currently running in order to create a common approach on Smart Cities, Such initiatives, even if of fundamental importance for the EU, have some relevant gaps not allowing them to fully cover fundamental aspects for Smart Cities, i.e. to define a common data framework allowing full interoperability among different city system, as well as a consistent vision on how ICT can support energy systems in smart cities. Within this context READY4SmartCities cover a unique role thanks to its specific mission of bringing together relevant stakeholders including engineering specialists, ICT software and equipment providers, RES providers, energy companies (including ESCOs – Energy Service Companies), construction sector companies, as well as local and regional authorities. In co-operation with these stakeholders, the aim is to deliver:\tA new energy data ecosystem that will accommodate cross-domain data (climatic, occupation, pollution, traffic, activity, etc.) and will allow the exploitation of such data at global scale; by identifying the set of ontologies relevant to energy-efficiency in Smart Cities and the different requirements and guidelines on how to use (publish and interchange) data described according to those ontologies.\tAn holistic and shared vision, allowing feasible step-by-step action plans for city authorities and other relevant stakeholder groups to develop and use ICT-based solutions for energy system in urban and rural communities towards future Smart Cities, and thus, leading to reduced energy consumption and CO2 emissions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Information flow in developmental cell fate patterning', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Embryonic development relies on the ability of multi-cellular systems to collectively coordinate the establishment of precise spatial patterns of cell fates. An inevitable obstacle to such coordination is intrinsic noise at the single-cell level, which constrains the amount of information accessible to cells for fate decisions. While such information was often considered to be encoded in overall concentrations of extracellular signals, it is becoming increasingly clear that cells use a much broader set of inputs to make decisions. In this project, we will develop a new data-driven theoretical framework of developmental patterning to quantify, characterize and predict how cells generate and process four types of information: dynamical signals, neighborhood interactions, tissue heterogeneity, and mechanical information. We will establish a novel theoretical methodology by uniting computational tissue models that account for single-cell noise with information theory to bridge the scales and relate mechano-chemical inputs to cell fate decisions. We will develop this approach in direct connection with spatio-temporal imaging experiments in two model systems. First, we will determine how regulatory interactions in 2D human gastruloids generate information encoded in complex signaling dynamics, and how single cells can use this information to decide their fate. Second, we will reveal how signaling and mechanics interplay to establish mechano-chemical information in intestinal organoids, driving simultaneous fate patterning and tissue morphogenesis. This project will uncover how cell-cell interactions establish self-organized spatial patterns that relay information accessible to single cells to reliably instruct cell fate decisions, and give insight into the fundamental constra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Endothelial Hedgehog autocrine signaling at the Blood Brain Barrier controls inflammatory Central Nervous System lesion size and severity through Gas1 co-receptor modulation.' under Horizon 2020.

assistant: **Concept**

Being at a major turning point in my career, after a rewarding postdoctoral fellowship in the United States, I’m applying to the MSCA-IF-2017 to ensure my return to Europe as an independent researcher in neurovascular biology. I built a proposal with the purpose of providing new understanding of Blood Brain Barrier (BBB) pathophysiology, particularly in the setting of Multiple Sclerosis. My hypothesis is that Desert Hedgehog-induced autocrine signaling in endothelial cells controls inflammatory lesion expansion via the regulation of intercellular junctions at the BBB through its co-receptor Gas1, and that this pathway may represent a new target for more effective therapies to prevent relapses and progression in Multiple Sclerosis.I choose to join the UMR Inserm U1034 to bring together my deep BBB knowledge and its unique expertise in Hedgehog signaling and vascular biology. Moreover the Bordeaux University, through its internationally recognized neuroscience campus, offers me an exceptional opportunity to develop fruitful collaborations with many distinguished researchers.My project is voluntarily built towards the exploitation of novel dynamic in vitro/in vivo BBB models requiring original microfluidic chamber design and 2-Photon live imaging (secondment in M. Nedergaard’s laboratory, Copenhagen), in vivo explorations of yet unpublished transgenic mice using high resolution imaging tools and the development of new molecules targeting original protein-protein interactions.As soon as I'll get exciting data, I will disseminate my work through seminars, international conferences and publications in high impact factor journals. Moreover, I will use the opportunities from both my hosting structure and Neurocampus programs to communicate to a wider audience (laboratory visits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Photonic Terahertz Signal Analyzers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Spectrum analysis and vector network analysis are enabling technologies for component development throughout the microwave and millimeter wave band. Due to the lack of affordable electronics for frequencies above 100 GHz, vector network analyzers (VNAs) have to use frequency extenders to reach into the THz frequency band (100 GHz-10 THz). The bandwidth of frequency extended electronic systems is restricted to about 50%. Several extender setups have to be used for larger spans, requiring realignment and tedious recalibration. Further, extenders become increasingly expensive the higher the THz frequency and are, therefore, barley used. Electronic spectrum analyzers face similar problems as VNAs. Only a few examples of highly expensive photonic, pulsed frequency comb-based systems have been demonstrated. Affordable, large bandwidth commercial THz metrology tools are missing so far. This proposal aims for the development of photonic THz characterization tools based on telecom-wavelength compatible photomixing technology to satisfy this need:1.) Photonic vector network analysers (PVNAs) with extreme frequency coverage will be realized by two approaches:   a) A planar, on-chip, and broadband dielectric waveguide topology with integrated photomixers for the realization of a continuous-wave (CW) two-port PVNA, covering at least 100 GHz to 1.1 THz in a single setup.   b) A pulsed, free space photonic two-port VNA for frequency extension towards 5 THz.2.) CW photonic THz spectrum analyzers (PSAs) with a frequency coverage of at least 50 GHz -1.1 THz and a simple extension towards 2.7 THz. This system will be realized both free space and on-chip by using a photonic sweep oscillator that is mixed with the signal to be investigated and down-converted by a room-temperature operating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Services to enhance innovation management capacities of SMEs in England, Northern Ireland and Wales' under Horizon 2020.

assistant: **Concept**

A national service in support of recipients of the H2020 SME Instrument and for the improvement of innovation managementin SMEs, with the purpose of more companies with growth potential achieving global scaling. Innovation is a vital ingredient of growth and an important element of the future success of the UK. With some 95% of R&D and innovation conducted outside of the UK and many major and lead market shaping companies being of non-UK origin, access to knowledge, markets, skills and partners is increasingly taking place on a global basis. To ensure UK business stays competitive it is important that it is able to effectively access and exploit the growing global investment in research and innovation.Through EEN ENIW activities we will help businesses build collaborations and partnerships and access the finance, knowledge, skills, networks and customers to more rapidly move a concept through to commercialisation and to scale their business.


**Keywords:** Innovation, innovation management, growth, scale-up, collaborations, commercialisation,  investment, internationalisation, account management, growth showcase, connections, global,  markets, partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A thermoelectric generator for low-grade heat to electricity/hydrogen conversion (H2E)' (H2E).

assistant: **Concept**

Heat-to-power conversion can be achieved by thermoelectric generators (TEGs), devices that exploit the Seebeck effect to build up an electric potential across a stack of semiconductors subjected to a temperature difference. This physical effect has long been known, but widespread application has remained limited because of the low efficiency (less than 5%) and high cost of available semiconductors, often containing rare metals and featuring high toxicity and poor thermal stability. Compared to alternative technologies for valorisation of low-grade heat, e.g., the Organic Rankine Cycle, TEG technology has substantial advantages, including lower weight and absence of moving parts. This leads to high reliability and low-maintenance, crucial attributes for the chemical process industry. Using less expensive semiconductor materials and increasing efficiency are the main challenges to broaden the application field of TEGs. H2E proposes a new approach to enable improved TEGs using a thermo-electrochemical-hydrogen production device (TEC-H) based on recently discovered, robust, low cost, non-toxic porous semiconductor materials. These new semiconductors are implemented in an original design, mounting them in stacks to produce a TEC-H device that is modular and exhibits good scalability. The resulting disruptive increase in efficiency will enable power generation with a decreased cost per unit power. H2E will valorise low-grade waste heat in the temperature range below 100 °C, a range currently not exploited in industry. Besides industrial waste heat, also low-grade geothermal heat represents huge potential. H2E aims to innovate the production of two end products: renewable electricity and green hydrogen - by water splitting. H2E will contribute to a more energy-efficient and lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Investigation of the expression of virulence factors in leishmania parasites - a comparative molecular analysis of the Mediterranean l infantum and the new world l chagasi' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content A number of species of Leishmania cause a disease spectrum ranging in severity from asymptomatic or mild infections to localised, diffuse or muco-cutaneous disease and visceral leishmaniasis. The final tropism of the parasite and the clinical outcome are most likely to be determined by an as yet unravelled complex interplay of molecules derived from the sandfly transmitting vector, the host immune arsenal molecules and the leishmania parasite itself. The main goal of the proposal is to investigate the gene encoding for an specific virulence factor in Leishmania chagasi or L infantum parasites causing either cutaneous or visceral leishmaniasis. In addition, transcripts would be compared between L chagasi and L infantum isolated from patients with cutaneous lesions or suffering visceral disease. The eventual aim is to gain a better understanding of the nature and role of parasite virulence genetic markers for predicting tropism and clinical outcome. Specific objectives are: 1. To define the organisation, copy number, chromosomal location and expression of the gene LPG1 encoding a galactofuranosyl transferase like enzyme in L. chagasi and L. infantum reference parasites from patients with either VL or CL. 2. To identify unique transcripts or quantitative differences in the relative abundance of transcripts by differential analysis of mRNAs of L. chagasi and L. infantum reference parasites from patients with either V1 or CL. 3. To investigate the role and essentiality of the Leishmania gene identified in 1 or 2, which best correlates with pathology, by functional complementation following Leishmania transfection. Training content (objective; benefit and expected impact) The main training goal is to transfer to the applicant the most complete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'ICARUS. INCREASING CIRCULARITY IN PROCESS INDUSTRIES BY UPCYCLING SECONDARY RESOURCES'.

assistant: **Concept**

ICARUS will upcycle waste material resources of most selected process industries (covering minerals, cement, ceramic, non-ferrous metals, steel, water, pulp&paper and chemical ones) to achieve circular and sustainable process industries overcoming their final application in construction sector. This project will accelerate the process industry uptake and contributing towards the developed education and skills activities and outcomes in this area as well as linking all value chain from industrial players recyclers, public authorities, and standardisation actors. ICARUS tackles resources usage in the construction sector (housing and infrastructure), accounting for 50% of the total material extraction, and being responsible for more than 35% of waste streams in the EU. Furthermore, the circular economy in the sector is still at a very early stage, with an estimated level of circularity for the  EU of 12.4%   material use rate in the year 2021. ICARUS approach aims to give technological support to stakeholders of energy-intensive and construction industries as key players for the transition to a more green and digital processes industries supported by standardization aspects to promote values and a resilient, green and digital Single Market and business models including co-creation and co-design to successful market implementation. ICARUS will represent a breakthrough in the research and demonstration of new technologies to upgrade Secondary Raw Materials ensuring similar quality as primary raw materials, of three waste streams to improve circular economy principles in several intensive industries with its implementation in the construction sector, to improve circular economy principles in P4P process industries. These new technologies will be demonstrated throughout 3 demo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High Performance Half Heusler Thermoelectrics for Waste Heat Recovery' (HIPERT).

assistant: **Concept**

This project aims to develop high-performance, low-cost and environmentally-friendly Half Heusler (HH) thermoelectric (TE) materials for waste heat recovery in mid-temperature applications. It is an interdisciplinary research program, combining research actions from five different scientific fields: Computational Materials Physics, Chemistry, Nanotechnology, Materials Science and Manufacturing Engineering. Theoretical approaches and calculations will support the experimental investigations for the discovery and development of new n- and p-type HH materials with the potential for high TE performances. A range of different strategies will be implemented in order to optimize their electrical transport properties and achieve in parallel high reductions in thermal conductivity through effective phonon scattering, targeting to efficiencies with TE figure-of-merit, ΖΤ, close to 2. The final objective of the project is the construction of a prototype TE device using the developed optimized materials and the evaluation of the final efficiency and produced power output of the device. The interdisciplinary nature of the project will give the researcher the chance to gain training and experience from diverse disciplines, learning new methodologies, expanding his scientific horizon, strengthening his professional maturity and becoming more independent for an Academic position.HIPERT will have a high impact on scientific community, while in log-term it is anticipated to be beneficial for the economy and society. The HIPERT research outputs will introduce new scientific concepts and will inspire further research for the development of high-performance thermoelectrics. In parallel, it is expected to open the road for the development of HH TE generators in industrial level, creating att
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of an intelligent and multi-hospital end-to-end surgical process management system' to be submitted under Horizon 2020.

assistant: **Abstract**

Healthcare expenditure represents on average 8.3% of European GDP. Hospitals are highly complex organisations, typically with thousands of employees and hundreds of admissions and operations performed every day, in large spread-out areas. They look very much like “micro-cities” and their costs represent an approximate staggering 60% of total healthcare expenditure. Daily operations in hospitals involve a range of time consuming and complicated processes (care, logistic, operative, etc.), which must run smoothly to provide (cost-) effective, safe and friendly healthcare assistance to the population. A medium-large hospital spends more than 70% of its yearly budget on surgical interventions. Healthcare cuts in recent years, sometimes reducing budgets by up to 10%, have made it more difficult to maintain the high quality and excellent performance of public health services. Indeed, waiting lists for surgical procedures are rising due to an increase in both healthcare demand and service cuts. Surprisingly, the most complex and expensive process in hospitals —the surgical process— is still managed in a rudimentary way by relying on professionals repeatedly phoning each other to look for available people (i.e. ancillary), information and essential items in time demanding situations. MYSPHERA has identified this need, which has no current solution in the market. By leveraging its cutting edge RTLS technology, MYSPHERA presents a unique and pioneering service in this project that will transform the delivery of healthcare in hospitals. Automating information, events and tasks will transform hospitals into proactive organisations. In turn, MYSPHERA will change its product portfolio to move into a higher position in the value chain. OR4.0 is an opportunity to boost one of the most