RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthesis of Diketopiperazine Based Bioactive Compounds via Palladium Catalyzed Cascade Alkynylation Reactions' (CasDKP).

assistant: **Concept**

More than 50% of drugs currently on the market are either natural product inspired derivatives or natural products. Despite this remarkable feat, the pharmaceutical industry has partly abandoned this traditional method of drug discovery resulting in a decline of newly approved drugs. In this context, we propose the development of a novel Pd-catalyzed cascade reaction to gain highly efficient entry into the diketopiperazine framework. Using this newly developed chemical tool, analogs of natural products with confirmed quorum sensing or anticancer properties will be synthesized. Quorum sensing represents a novel therapeutic target to fight bacteria, which is especially attractive in light of the ever-expanding bacterial drug resistance, as it is based on bacterial cell-to-cell signaling disruption. Thus, we propose the synthesis of a series of diketopiperazine derivatives, based on the structure of known diketopiperazine based natural quorum sensing modulators. This task will additionally result in the implementation of a biological screening subunit within the host group. Furthermore, we aim to utilize the cascade reaction to access a series of tryprostatin A and B analogs (promising anticancer agents). A highly convergent approach is proposed herein, allowing for the synthesis of these chemical entities in half as many steps in comparison to the current “state-of-the-art” method. The synthesized derivatives will be assessed for their anticancer activity in collaboration with leading experts of the field. Thus, the proposed project entails a multidisciplinary, trans-national effort to find novel potent bioactive compounds that will certainly represent a high-quality contribution to advance the fields of Organic Chemistry, Medicinal Chemistry, Biology and Microbiology wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bayesian inference in neural dynamics: linking biophysical and computational approaches to neuroscience' in the context of a Sixth Framework call.

assistant: **Objectives**

The team project is to identify the neural mechanisms that form our internal belief systems, and to learn how optimal strategies and decisions are generated in an unpredictable and ever changing world. To do so we will integrate complementary computation al neuroscience approaches. The first studies neurons and neural networks as biophysical entities, concentrating on mathematically describing their dynamical properties. We will integrate it with efforts to infer what is the computational role of neurons a nd neural networks. In particular we consider the Bayesian framework that has been very successful for describing human and animal behavior and learning in perceptual and motor domains. It explains how probable perceptual interpretations or expected outcom es of actions can be computed from ambiguous sensory data and prior knowledge about the likelihood of events. Despite the logical attractiveness of such probabilistic computations, their neural basis remains largely unexplained. We shall consider that comp utations at the single cell, network and brain level can be described as Bayesian inference and learning in progressively more complex statistical models. Thus, the most exquisite aspects of single neurons and synaptic dynamic might have a direct behaviora l correlate. The originality of our approach is to provide both a novel canonical model to describe the complex dynamics of neurons and synapses, and a new theory of neural coding, thus bridging the gap between levels of analyses traditionally considered a s distinct. We will use analytical tools and computer simulations, combining expertise in neuroscience, physics and machine learning. The ensuing models will be tested against the important body of pre-existing literature in experimental neuroscience. Our appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Being precautionary: how rational? How ethical?'.

assistant: **Objectives**

Human decisions can be evaluated on whether they exemplify some precaution. For instance, the mayor was praised for being precautionary in reinforcing the dike along the river. Precaution has recently been raised at the level of a principle – the Precautionary Principle – which has acquired a widely recognized status in national and international law. This project conducts a philosophical analysis of conceptual and fundamental issues on the Precautionary Principle and on precaution more generally. I aim at understanding why being precautionary makes sense from a rational viewpoint, both at the individual (Objective A) and collective (Objective B) levels, and from an ethical viewpoint (objective C).- Objective A is to clarify the relation between the Precautionary Principle and decision theory more generally, by specifying whether there are inconsistencies or unnoticed linked between the two. I will investigate whether the Precautionary Principle can apply gradually, and whether it amounts to some uncertainty aversion or risk aversion.- Objective B is to understand what being precautionary as a group implies. I aim to specify on what conditions a group can be precautionary and consistent, or rational, in its judgments. My strategy is to extend the existing belief and probability aggregation theories, and state (im)possibility theorems.- Objective C is to determine what being ethically precautionary could mean. Since being precautionary for oneself may amount to impose risk on others, I aim to assess the particular ethical problems it may create. I shall proceed comparatively, starting from existing views in the ethics of risk.The project combines several methods: conceptual analysis, formal/mathematical modelling, the analysis of case-studies, and an innovative cross-fer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ex vivo gene therapy for GM1-gangliosidosis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

GM-gangliosidosis (OMIM #230500) is a rare, autosomal recessive, neurodegenerative Lysosomal Storage Disorder. It is caused by mutations in the GLB1 gene, encoding the lysosomal hydrolase β-galactosidase. Infantile GM1-gangliosidosis is characterized by neurodevelopmental delay, hypotonia, dysphagia, seizures and death by 3 years of life. Due to the rapid progression and severe nature of this disease, which involves storage of undegraded metabolites and secondary mechanisms of cell damage, correction requires a rapid and robust enzyme delivery to the whole central nervous system (CNS), possibly associated to reduction of local inflammation. Here we propose an ex vivo gene therapy (GT) strategy aimed at preventing or ameliorating the symptoms of the disease in the murine model. Multiple copies of GLB1, alone or in association with a neuroprotective factor, will be delivered ex vivo to hematopoietic stem/progenitor cells by lentiviral gene transfer to determine a sustained and robust expression of the therapeutic enzyme in the CNS of transplanted mice. Genetically modified HSPCs will be administered by a novel approach combining the conventional intravenous route with direct administration into the brain lateral ventricles, to anticipate the myeloid reconstitution in the brain and possibly the therapeutic effect. Our working hypothesis is that this optimized GT strategy could successfully control disease manifestations in the animal model. Moreover, a deep genome-wide genomics analysis will be performed on individual brain cells to elucidate the molecular mechanisms at the basis of the disease and mediating the therapeutic effect. The study will generate a proof of concept for a future clinical development of an efficacious ex vivo GT for infantile GM1-gangliosidosis and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Trade-off between reproductive effort and anti-haemoparasite defense in birds - cummulative effects of laying more eggs', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The Proposal is intended as fundamental research to provide important tools for the simulation of short fibre reinforced injection moulded parts and their properties. By extending the Elementary Volume Concept (EVC), properties of any short fibn reinforced composite may be determined by transforming the stiffness and compliance tensors with a fourth rank fibre orientation tensor. Unique facilities at IKP will allow processing of injection moulded parts using the push pull technique, providing short fibre reinforced parts with almost unidirectional properties. Sampling and characterisation of such a material will serve to evaluate and verify the extended EVC model. The EVC represents an important link for simulation of mould filling and resulting part properties. The implementation of the EVC in such software packages allows for optimised mould design and optimised part properties of injection moulded short fibre reinforced composites. This would lead to shorter development times and reduced development costs. An environmental and economic impact is also to be expected because of saving raw material with optimised part designs. Training content (objective, benefit and expected impact) To introduce a more theoretical basis to my research experience and to extend experimental skills to further fields such as polymer processing and special mechanical testing procedures. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Function and mechanism of viral miRNAs in cytomegalovirus infection' to be submitted under Sixth Framework.

assistant: **Abstract**

This project addresses a fundamental and pressing question in gene regulation: the function of microRNAs (miRNAs). Discovered only in the last decade, these small (~22 nt) RNAs represent an important new class of molecules and are expected to play large, and previously unrecognized, roles in numerous cellular pathways.We propose to use murine cytomegalovirus (MCMV) as a tool to study miRNA function, by examining the target specificity of the MCMV miRNAs, and the influence of the miRNAs on the gene pathways involved in infection. Specifically, this project will utilize microarray and proteomic strategies to define the gene factors whose expression is altered by viral miRNAs.Results will be mapped onto viral and host gene networks in order to examine the local or global influence of each miRNA. Overall, the planned studies will provide critical new information on the function of mircroRNAs in a viral system and will shed light on viral/host interactions important for infection.The results will provide an important framework with which to evaluate miRNA function in other (potentially more complex) systems. Novel detection strategies for miRNAs will also be explored, as these RNA molecules are expected to represent a new class of biomarkers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Decentralised Direct Air Capture The most sustainable, affordable and scalable way to produce clean CO2 on demand'.

assistant: **Objectives**

Finalist of the 2021 KVK innovatie Top 100, with the Solar Impulse Efficient Solution label, finalist at Connect22, winner at Japan's Plug & Play 2023 and spun off from the European Space Agency, Skytree is a Climate Tech company developing small-scale carbon capture solutions to produce clean CO2 directly where it is needed. The unique size of our decentralised direct air capture (DDAC) units opens up new multi-million opportunities in sectors where fossil fuels-based CO2 supply is increasingly expensive and uncertain, e.g. greenhouse farming (our beachhead market), CO2 feedstock, and many more. The modular architecture of our DDAC units allows the deployment of easily scalable 100% custom plug-and-play CO2 production systems, while waste heat integration will allow reducing energy consumption and OPEX. Our ambition is to drive the use of clean CO2 to boost crop yield while ending reliance on fossil fuels, thus guaranteeing more resilient, sovereign and sustainable greenhouse farming.


**Keywords:** Carbon Capture, Decentralised Direct Air Capture, Food sovereignty, Resilient agriculture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Research Infrastructures Network of National Contact Points' to be submitted under Seventh Framework.

assistant: **Abstract**

The term “Research Infrastructures (RIs)” refers to facilities and resources that provide to the scientific community essential services needed for the performance of leading edge research in both an academic and/or industrial environment. Research Infrastructures should be open to researchers, to the scientific community and to the Industry and cover the whole range of scientific and technological fields.  The Research Infrastructures are of high importance in order to strengthen the knowledge base of Scientifc Communities and the technological know-how of Industrial sector across Europe.   The overall objective of the proposed project is: To support the efficient implementation of the Research Infrastructures Programme and to promote the benefities offered by the RIs in order to enhance the Research Excellence, the competitiveness and the growth of Europe.   Within this framework the project aims to improve the effectiveness of the Research Infrastructures (RIs)  NCPs network through the upgrade of the level of the  transnational cooperation which will result in more consistent services provided to the customers/clients across Europe.  Coordination activities and synergies with other EU Networks will promote a coherent approach towards the Research Infrastructures and their utilization for the benefits of the European Scientific Community and Industry.  The NCPs within each particular country represent different administrative and organisational schemes and patterns. The lack of coordination activities between NCPs frequently leads to obstacles both for the NCPs and the Researchers and requires more efforts by the European Commission for the effective implementation of the Programme itself.  The project will focus on the establishment of a unified approach to RIs NCPs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REVOLUTIONIZING TELECOM SECURITY AND RELIABILITY THROUGH DE-IDENTIFIED AND ROBUST COMMUNICATION' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Privacy infringment is one of the most prevalent forms of cybercrime, accounting for about 72% of all cybercrimes alone. Such is also the case with speaker biometrics, which, if compromised over a call, can be manipulated to generate fake speech to impersonate a person. Such identity theft over voice calls can cause financial losses, cyber-bullying and fake hate speech generation. On the other hand, in parts of the world where the communication infrastructure is not robust, a person is more agitated over not being able to get his message across over a call due to channel breakage. In such cases, privacy concerns take a back seat; but that does not imply the absence of the threat. To that end, I propose a joint solution to these issues, that can be integrated with the existing communication infrastructure. The solution consists of two segments: far-end and near-end. The far-end segment shall handle the speaker de-identification task. Existing methods of speaker anonymization are limited in terms of achievable anonymity. Improvements can be made through cycle-consistent GAN to generate better synthetic speaker representation vectors. I plan on surpassing the existing benchmark in terms of lower automatic speaker verification (ASV) scores and good automatic speech recogntion (ASR) scores. Additionally, the entire segment would be brought online for integration with real-time communication systems. The near-end segment shall be handling the speech inpainting task. While existing techniques are able to fill the blanks in acoustic signals pertaining to music and background sounds quite well, they are ill-equipped for speech. The existing speech inpainting techniques chiefly rely on spectrogram-based approaches which result in unnatural reconstructions. I plan to study novel a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Programmable maximum integrated electronic trip unit' to be submitted under Fourth Framework.

assistant: **Abstract**

To realise an electronic trip unit based on a single ASIC with the following specification- current range 200A to 200 000A- 0.1% relative accuracy- fully compliant with EMC, mechanical and climatic standards- protection modes: instantaneous, short time, long time, ground fault.To develop an ASIC that contains the analogue interface for the trip unit and includes the required functionality.To design an analogue front end with 12 bit accuracy and low offset 50-100uV.Actuator trip units of an electricity circuit power breaker suffer from lack of accuracy which limits their installation and exploitation. The use of electronic actuator trip units consisting of a single mixed mode ASIC would not only allow an economical implementation of the required accuracy, it would also allow additional functionality such as programmability for greater flexibility and remote monitoring of individual loads via the EMS TP0 Home Systems Communication interface.The biggest challenge for the circuit is the design of a high sensitivity front end for equipment that switches currents of several thousands of amperes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tyre Recycling Pyrolysis for producing oil with less than 0.2% sulphur content, low cost sulphur impregnated carbon for reducing mercury air emissions, with simultaneous elemental' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

SULFREE offers a complete, end-to-end process for ELT recycling, which breaks down tyres to valuable productsthat can be reused by the EU tyre industry; instead of merely recycling them either as tyre crumb or as fuel (i.e.tyres are burned for power production). The recovery of oil and sulphur reduces the dependence on importedproducts and lessens the effect of price volatility on tyre production whereas the sulphur-impregnatedactivated carbon (S-AC) will aid in reducing mercury emissions.The project will (a) develop a novel, platform technology implementing a specially designed Fixed Bed Reactorfor the hydrodesulphurisation of the pyrolysis vapour (combined oil and gas fraction), resulting in a gas rich inhydrogen sulphide (H2S) and oil with sulphur content less than 0.2%, (b) develop a monoethanolamine (MEA)stripper to capture H2S from the gas and optimize the Claus Process for recovering the sulphur (c) optimizemicrowave pyrolysis technology for breaking down end of life tyres and (d) optimize the technology foractivating the solid carbon black. The gas and heat produced during the process will be used for the energyrequirements of the process and for activating the solid carbon black. The major novelty of the process is thatthe fixed bed reactor, the MEA stripper and the Claus process will design and operate at a significantly smallerscale.