RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Provably Correct Networks' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Networks are the backbone of our society, but configuring them is error-prone and tedious: misconfigured networks result in headline grabbing network outages that affect many users and hurt company revenues while security breaches that endanger millions of customers. There are currently no guarantees that deployed networks correctly implement their operator’s policy.Existing research has focused on two directions: a) low level analysis and instrumentation of real networking code prevents memory bugs in individual network elements, but does not capture network-wide properties desired by operators such as reachability or loop freedom; b) high-level analysis of network-wide properties to verify operator policies on abstract network models; unfortunately, there are no guarantees that the models are an accurate representation of the real network code, and often low-level errors invalidate the conclusions of the high-level analysis.We propose to achieve provably correct networks by simultaneously targeting both low-level security concerns and network-wide policy compliance checking. Our key proposal is to rely on exhaustive network symbolic execution for verification and to automatically generate provably correct implementations from network models. Generating efficient code that is equivalent to the model poses great challenges that we will address with three key contributions:a)We will develop a novel theoretical equivalence framework based on symbolic execution semantics, as well as equivalence-preserving model transformations to automatically optimize network models for runtime efficiency.b)We will develop compilers that take network models and generate functionally equivalent and efficient executable code for different targets (e.g. P4 and C). c)We will design algorithms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Austrian presidency conference on European technology platforms' (ETP-AUCON).

assistant: **Concept**

The aim of this project is to organize the Austrian Presidency Conference on European Technology Platforms" on 4/5 May 2006 in Vienna for max. 450 persons. Organising Institution is the FFG, The Austrian Research Promotion Agency. The high-level 1 1/2 day Conference on European Technology Platforms is one of the official events of the Austrian EU-presidency in the first half of 2006. Purpose and focus: The central themes of the event are the European Technology Platforms and their impact on FP7 and European competitiveness.The aim is to bring together for the first time a wide-ranging audience in order to raise awareness and discuss horizontal issues relevant to ETPs. The focus of the first day will to discuss experience to date with European Technology Platforms (ETPs), their contribution to industry driven research in Europe and to the Lisbon strategy for a more competitive Europe. The second day deals with the implementation of European Technology Platforms during FP7 and beyond."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hospital schools' guidelines On Physical Education (HOPE): An International, Interdisciplinary and Intersectoral Endeavour.' to be submitted under Horizon Europe.

assistant: **Abstract**

Built on the European priorities on digital and technological empowerment as well as equal, tolerant and fair way of life for all citizens despite their condition, the ""Hospital schools' guidelines On Physical Education"" (HOPE) project is a 42-month pioneering initiative aimed at developing transnational guidelines to enhance the quality of physical education for students in hospital schools, offering a unique scientific, social and economic contribution across and outside Europe.The HOPE project is anchored in a robust framework of research objectives to develop evidence- and eminence-based knowledge. This includes: i) a comprehensive desk analysis and Delphi method encompassing a systematic review, international focus groups and surveys, and ii) a solid andragogical structure construction to be applied through pilot studies of a multilingual online program for PE teachers and further developed by means of the International Judo Federation involvement.Within the project, the trainee supervision is powered by an advisory board with a mentorship approach, ensuring guidance and support from expert professionals in the fields of sport, movement, education, psychology, and health sciences within and outside academia.Involving stakeholders from mixed backgrounds and recognising the gender- and diversity-dimensions, the HOPE multifaceted research not only enhances the reliability of the guidelines but also ensures their applicability across diverse hospital school contexts and in the post-hospitalization transition.Including a 6-month non-academic placement to expand the project outcomes and foster the trainee soft and transferable skills, HOPE is sustainable, adaptable and long-running.Finally, a solid collaborative partnership and a thorough risk assessment ensure proacti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Improved Resilience and Sustainable Reconstruction of Cultural  Heritage Areas to cope with Climate Change and Other Hazards based on Innovative Algorithms and Modelling Tools'.

assistant: **Concept**

YADES aims to efficiently train a network of fellows on the field of the resilience of Cultural Heritage (CH) areas and historic cities against Climate Change (CC) and other types of hazards. Towards this direction, YADES aims to introduce a research framework for downscaling the created climate and atmospheric composition as well as associated risk maps down to the 1x1 km (historic area) scale, and specific damage functions for CH materials. Applying atmospheric modelling for specific CC scenarios at such refined spatial and time scales allows for an accurate quantitative and qualitative impact assessment of the estimated micro-climatic and atmospheric stressors. YADES will perform combined structural/geotechnical analysis of the CH sites and damage assessment under normal and changed conditions, based on the climatic zone, the micro-climate conditions, the petrographic and textural features of building materials, historic data for the structures, the effect of previous restoration processes and the environmental/physical characteristics of the surrounding environment. The data coming from installed monitoring system will be coupled with simulated data (under our cultural heritage resilience assessment platform-CHRAP) and will be further analysed through our data management system, while supporting communities’ participation and public awareness. The data from the monitoring system will feed the DSS so as to provide proper adaptation and mitigation strategies. The produced vulnerability map will be used by the local authorities to assess the threats of CC (and other natural hazards), visualize the built heritage and cultural landscape under future climate scenarios, model the effects of different adaptation strategies, and ultimately prioritize any rehabilitation actio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Search for new physics through lattice simulations' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Despite its monumental success, we have reason to think that the Standard Model of particle physics is an effective description of a more fundamental theory. In order to maximise the chances of success of experiments to pinpoint the breakdown of this theory, it is crucial to provide precise, ab-initio theoretical predictions to compare it with. One of the main challenges in producing these predictions is to reliably take account of the non-perturbative, confining phase of the strong interaction. So far, the most efficient way to achieve that is to use numerical lattice simulations. In this proposal, I focus on theoretical quantities involved in the search for new physics and propose an ambitious lattice simulation programme to determine them precisely. Firstly, I propose to predict rare kaon decays amplitudes. These decays are extremely rare in the Standard Model and are expected to be sensitive to new physics. Secondly, I propose to determine how to include isospin breaking effects in the calculation of the anomalous magnetic moment of the muon and meson leptonic and semi-leptonic decay rates. Including these effects is a highly non-trivial task which is necessary to push the theoretical precision of these observables beyond the percent level in order to provide a higher constraint on the Standard Model. Thirdly, I propose to explore holographic cosmology, an ambitious and innovative alternative to ΛCDM, the ""standard model"" of cosmology. Finally, all these projects will directly contribute to the development of Grid, the emerging world-leading software solution for lattice simulations. All these projects are strongly pushing the boundaries of the application of lattice simulations and the results will be confronted with experimental measurements within the next five
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Population Genetics and Control of Triatoma Brasiliensis in North East Brazil', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

* To improve knowledge of the biology and population genetics of Triatoma brasiliensis in support of entomological surveillance and control activities against Chagas disease in North East Brazil, including development of genetic and/or phenetic markers suitable for identifying the source of new infestations.* To encourage greater collaboration between research scientists and Chagas disease control authorities throughout the arid Caatinga of North East Brazil.Expected Outcome* improved geographic database of T. brasiliensis distribution* establishment of laboratory colonies from well characterised localities* basic life-table data under different laboratory conditions* discriminant analysis based on 11-18 morphometric variables and ratios, and on up to 25 gene loci represented by isoenzymes* preliminary karyotype analysis and RAPD data* analysis of geographic structuring of T. brasiliensis populations, and preliminary estimates of gene dispersal between neighbouring populations* detailed characterisation of field trial localities, and liaison with industries interested to participate in field trials* laboratory flight studies indicating key factors influencing flight initiation* possible genetic markers for flight capacity* field studies using light traps to estimate potential flight range* morphometric and genetic characterisations suitable for analysis of reinfestations* evaluation of reinfestations following control trials, and reassessment of morphometric and biochemical profiles.(Note that during the course of this work we also expect to gather preliminary data on other species of Triatominae found in the same region as T. brasiliensis, which might become of greater epidemiological significance in the future.)* Background field work in selected municipalities of Cea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Design of inhibitors of blood platelet collagen interaction'.

assistant: **Innovation**

A major challenge in the field of cardiovascular research is:a) the understanding of the molecular mechanisms underlying blood platelet interactions with the vasculature and (b) the development of cell-type and receptor specific antagonists to prevent uncontrolled platelet adhesion events leading to cardiovascular diseases. The deposition of platelets on thrombogenic surfaces such as ruptured arthero-sclerotic plaques may provoke acute vascular occlusion resulting in myocardial infarction, transienti schemic attacks or stroke, together the first cause of death in our Western society. Within the damaged vessel wall, collagens are the most abundant thrombogenic substances. Platelet adhesion to collagen occurs both directly, through binding to the integ in receptor a2b1, and indirectly via von Wille brand Factor (vWF) forming the bridge between collagen and the vWF platelet receptor, glycoprotein (GP) Ib. The latter interaction only occurs following a conformational change in vWF, e.g. as a consequence of the shear stress exerted by the flowing blood on vWF immobilised onto collagen. As a result of these interactions, platelets become activated and GPIIb/IIIa (or integrinaIIbb3) becomes competent to bind fibrinogen and vWF. Both are able to cross link adjacent platelets, finally resulting in a platelet plug. In the present project it is our intention to develop compounds that will interfere with the very first stages of thrombus formation, e.g. adhesion of platelets to the damaged vessel.To this end we want to use a set of complementary approaches including the generation of recombinant binding domains of the different ligands/receptors, monoclonal antibodies and peptides, selected based on PEPSCAN analysis, phage display technology and crystal structure information. In ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Incorporation of unnatural fluorinated amino acids to probe the function of the bacterial efflux system Kef in a cellular setting.' (FLUOROKEF).

assistant: **Innovation**

The potassium efflux system, Kef, protects bacteria against the detrimental effects of electrophilic compounds via acidification of the cytoplasm. Its vital role in maintaining cell homeostasis makes Kef a promising target for antibiotics, but such drugs can be developed only with a molecular understanding of Kef activation. Our work indicates that phenylalanine residue 441 (F441) in Escherichia coli is crucial for the activation of K+ efflux. This mechanism is conserved, and F448 of Shewanella denitrificans Kef (SdKef) has the same function. This work employed X-ray crystallographic studies using a truncated construct of the E. coli Kef soluble C-terminal domain (EcKefCTD) and biophysical studies conducted on the SdKef C-terminal domain (SdKefCTD). While the crystallographic studies have been essential in hypothesis generation, they lack the dynamic aspect that is required to understand the mechanism of Kef activation. Although the use of a truncated construct has allowed development of biophysical assays, we wish to extend our work to focus on the full-length channel. To achieve these aims we will employ whole cell 19F NMR to probe the function of Kef.To determine if 19F NMR can be used to monitor F448 conformation, we will employ amber stop codon technology to replace F448 of SdKef with 4-trifluromethyl-L-phenylalanine (tfmF). We will monitor the dynamics of F448tfmF by 19F NMR upon binding of activators and inhibitors, using our library of SdKef ligands. To gain an understanding of Kef activation in cells, we will quantitatively determine binding affinities of the Kef ligands to SdKef(F448tfmF), in E. coli transformants using in-cell 19F NMR. This direct determination of binding inside the cells will be more physiologically relevant than the in vitro KD data. To ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The European socio-economic models of a knowledge-based society' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The project will propose an analysis of the socio-economic models in Europe, the transformations affecting them at the macro and the micro levels; it will assess the chances of emergence of a specific European socio-economic model distinct from the models existing in other developed regions of the world and will analyse how it can represent an original path towards the knowledge-based society.Our project will first devise analytical matrices to analyse the macro-level (socio-economic model) and the micro/meso level (productive models). The originality of the project is that a socio-economic model is defined as a set of complementary institutions that rest on a socio-political equilibrium. Therefore, any transformation of the model or pressure for convergence towards another model must not be assessed in terms of comparative performance only, but more fundamentally in terms of the transformations of the socio-political equilibriums that underlie a given institutional structure. This applies at the macro as well as at the micro -level, since institutional change and social compromises can take place at all levels, and transformation in productive models may lead to major transformations of a given socio-economic model.We will :- analyse the transformations in Europe making use of the analytical tools developed during the project and see how the changes taking place at the macro/societal level and at the micro/company level interact;- assess how the transformations in the employment relationship, the financial relationship and the productive organisation lead to an alteration of the European model(s);- study how these modifications may lead to the emergence of a specific European model exhibiting distinct characteristics or to convergence towards a market-based model;- ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of DOR, a novel gene involved in diabetes' (2002-2006).

assistant: **Innovation**

Diabetes has a huge global impact, making it one of the priorities of biomedical research. During my post-doc, I characterised a novel gene named DOR - Diabetes and Obesity Regulated, connected with diabetes and obesity. DOR is a nuclear coactivator that enhances the transcriptional activity of several nuclear receptors. Our results suggest a new pathway involved in the pathophysiology of type 2 diabetes. The proposed project aims to understand how the expression of the DOR gene is regulated in skeletal muscle and adipose tissues under normal physiological conditions. For this, after an in silico study of the DOR promoter, the human promoter will be analysed in cultured cell lines of those tissues. We expect to find common regulatory elements, which will be studied with suitable methodologies. Deletion analysis of the promoter will be performed, and regions involved in transcriptional control will be further analysed to identify binding motives and the corresponding transcription factors. Moreover, the role of methylation and of selected pharmacologically active substances in DOR expression will be studied. Further important information about DOR regulation will derive from the analysis of a single nucleotide polymorphism in the promoter. Continuing the characterisation of this novel gene will surely be a major contribution to unravel the aetiology of obesity and type 2 diabetes. The expected results have a great potential to increase the competitiveness of the European biomedical industry and to contribute to better and more cost-efficient health care. This project is the basis for my reintegration into the Institute of my PhD. I return as a group leader to start a new line of research, getting the opportunity to develop an excellent scientific career, aiming at a prof