RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Coordinating and Leveraging regional knowledge for initiating a Sustainable and optimised EU Waste to Energy Programme' (COOLSWEEP) under Seventh Framework.

assistant: **Objectives**

COOLSWEEP comprises 5 established research driven triple helix clusters, one cluster under development and a specialist cluster analysis organisation. The clusters have recognised that the newly emerging field of waste-to-energy urgently requires the establishment of a coordinated “smart specialisation strategy‟.The proposed work will compare and contrast the 6 regions to determine the global picture in terms of resources available and needs for technology implementation establishing synergies and identifying the basis for effective collaborations.  This will enable the development of a Joint action Plan, the finance plan necessary for implementation and the metrics to monitor and measure the effectiveness of the proposed interventions.  Throughout the project there are many dissemination and exchange events planned among the partners working on the project and the members of the regional clusters active in the field.  It is intended that these actions also look beyond the immediate project participants and engage the wider audience with specific targeted events and actions to support the project’s outreach ambitions.The project resources available to the clusters provide a wealth of relevant expertise either directly through the cluster or through Third Party association of organisations that are cluster members.  In addition, there are key international clusters and regional authorities represented on the Advisory Board to support specific project work packages.The project will develop the necessary momentum and critical mass to have a significant impact in this exciting technology field and also to create a sustainable and effective network between the clusters.  The expected impacts not only include development of frontier and breakthrough research but also address
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Earth Observation Multi-mission federation layer'.

assistant: **Objectives**

The DOMINO-E project, proposed by a consortium of European organisations, including scientific institutes and SMEs and led by Airbus Defence and Space, aims at solving the key challenge of availability and reactivity of earth observations from space, by enabling multi-mission accessibility on a scalable and automated way. The implementation of a multi-mission/multi-sensor federation layer allows the end-user to address a variety of acquisition assets using scheduling and optimization algorithms. The orchestration between the users’ patrimonial missions and the third party missions is based on reactivity, persistence, precision and costs criteria, while user experience is improved thanks to cognitive assistants.The challenge is to overcome the current technological, architectural and economical roadblocks of existing mission ground segments: mono-mission architectures, un-harmonized interfaces between different ground segments, inexistent or crude multi-mission collaborative coverage and dispatch services.DOMINO-E consists of designing, analysing and modelling the multi-mission federation layer based on users’ requirements and is supported by demonstrations of added value services. A market analysis is performed to assess the commercial perspectives of multi-mission federation approach in terms of client acceptance in sharing assets, industry’s make or buy strategy and SME capability to build catalogues of multi-mission services. This innovative federation layer supports the change of space industry paradigm from instrumental push to end-client vertical needs pull and allows the EU space industry to embrace the emerging data driven space market. In such, DOMINO-E contributes to European non-dependence for the development of Earth-observation technologies and foster Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Astrocytic Metabolic Reprogramming as a Therapeutic Target for Alzheimer’s Disease'.

assistant: **Innovation**

Alzheimer's disease (AD) represents a growing public health challenge, with its prevalence steadily increasing profoundly affecting both patients and their families. Despite extensive research focusing on amyloid-beta and tau as central pathological hallmarks of AD, the crucial role of astrocytic metabolism in neurodegeneration has often been overlooked. The HyperAstroMet project introduces a novel approach by investigating astrocytic hypermetabolism as a pivotal driver of neuronal hyperexcitability, dysfunction, and cognitive decline in AD. Astrocytes, integral to brain energy homeostasis, undergo significant metabolic reprogramming in the context of AD, marked by excessive glycolysis, altered glycogen storage, and disrupted insulin receptor signaling. These metabolic disturbances are thought to contribute to disease progression, yet their precise mechanisms remain poorly understood.This project aims to unravel the complex interplay between astrocytic metabolic dysfunction and neuronal degeneration in AD. Specifically, it seeks to identify new molecular targets for therapeutic intervention by elucidating how astrocytic hypermetabolism exacerbates neuronal dysfunction. Preliminary data from our lab suggest that targeting astrocytic glycolysis, particularly through GLUT1 ablation, can alleviate cognitive deficits and preserve neuronal integrity, potentially through compensatory upregulation of insulin receptor signaling. However, the underlying mechanisms driving these improvements are still not fully elucidated.To address these knowledge gaps, HyperAstroMet employs cutting-edge methodologies, to monitor real-time astrocyte and neuronal activity and to dissect the therapeutic potential of targeting astrocytic metabolism. By focusing on astrocytic metabolic dysfunction, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Growing bone fast and cost-effective' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

XPAND Biotechnology BV has developed a new generation of orthopaedic materials: the EpitaxOs bone regeneration material. EpitaxOs (TRL 6) is unique:a) it seduces the body to form boneb) is as effective as the golden standard autograft without its disadvantages (extra operative procedure, pain, limited quantity available)c) it is superior to other synthetic bone graft materials, allograft, growth factors and cell-based technologiesd) it is available in abundant quantities e) it increases the quality of life for patients as the use of EpitaxOs  has no adverse effects on the patient. The innovative property of EpitaxOs is its patented surface nano-structure, which induces the formation of bone by attracting the patient’s own stem cells to the defect site and stimulate them to make autologous bone (in situ bone tissue regeneration). Similar to autograft and growth factors and unlike other synthetic materials, EpitaxOs is a true bone inducing material, but generates bone much fasterEpitaxOs is targeted at the €4 billion spinal market and the €200 million dental market. The exceptional bone inducing properties of EpitaxOs put it in a unique position to replace autograft, (processed) allograft and growth factors.The CHARME project aims at bringing EpitaxOs from technological maturity level TRL6 to a successful commercial/ production launch at level TRL 8/9 (in 2017). The objectives are: 1. Development of a commercial scale production infrastructure2. Regulatory submission of EpitaxOs in key markets3. Providing evidence-based data to demonstrate product superiority and facilitate product launch & market acceptance4. Establishment of a marketing channel and development of a strategy for commercialisation of EpitaxOs The endpoints of the CHARME project will be EpitaxO, a commerci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engineering Excited States, Orbital Coupling and Quantum Coherence Phenomena in Photoelectrochemical Energy Conversion Devices' to be submitted under Horizon Europe.

assistant: **Abstract**

Excited aims to advance fundamental understanding to light-initiated reactions in molecular sensitizers that can display quantumcoherent behaviour in their excited state dynamics at room temperature. Moreover, it will focus also on the investigation of quantum coherent contributions to the solar-to-energy conversion efficiency in solar cells.Understanding the importance of quantum-coherent dynamics in biological systems has been key to assess whether this phenomenon is not just present but key for the control, and command, of the energy transport in molecular based systems. It is of utmost importance to validate models in which these quantum phenomena can be translated to materials that provide efficient solar to power conversion technologies.Excited is not only a project where molecular solar cells will be fabricated and their physical properties will be measured. Excited goes well beyond that, and will pave the way for the development of solar cells that will be tailor-made to make use of quantum coherence, molecular hybridization and orbital coupling effects to increase the solar to energy conversion efficiency. It is clear that this challenge can only be successful under the scope of a multidisciplinary perspective open to new and feasible reasonable hypothesis. Therefore, I will make use of the research group knowledge on synthetic chemistry that has allowed us to obtain numerous sensitizers for solar cells applications, as well as, for semiconductor metal oxides. Moreover, I will take advantage of our experience in advanced experimental time-resolved techniques to study quantum coherent effects and solar cells under operandoconditions. Excited will have a key impact on several fields, from biology to chemistry and physics and will bring paramount breakthroughs in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Roots and bacteria: Basis of attraction' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Root microbiome research is motivated by the promise of using growth-promoting, disease-suppressive bacteria as transferable, protective agents in agriculture. Yet, such approaches have not realized their potential as pesticide or fertilizer alternatives. Major obstacle are soil physico-chemical complexity and a staggeringly complex biotic environment. Recent establishments of synthetic communities promise to enable mechanistic understanding of bacterial establishment in the rhizosphere. However, current methods crucially lack in spatial and temporal resolution. The root is an assembly of dynamically evolving, distinct micro-niches for bacterial colonization that I propose to characterize by extensive use of fluorescent microbial marker strains, monitoring of bacterial metabolism and tracing of proliferation and taxis. This is complemented by precise manipulations of root development. The fractal, open-growth of roots must result in rapid changes in nutrient composition and cycles of nutrient abundance and restriction, forcing bacteria to oscillate between different survival strategies. These fundamental aspects of micro-niche formation, change and collapse are largely undescribed, yet central to understand success or failure of bacterial colonization. I propose to visualize and dissect these processes by combining cutting-edge tools for visualization, optical and genetic manipulations of both plant and bacteria. Bacterial model systems will be inserted into defined bacterial culture collections and results from mono-associations will be challenged by soil-based gnotobiotic systems and high-resolution community profiling. This project will reveal central, dynamic aspects of bacteria-root interactions within a realistic, time-resolved framework of root development. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Single Molecule Imaging Mass Spectrometry' in the context of a Horizon 2020 call.

assistant: **Objectives**

We aim to demonstrate the disruptive commercial and societal potential of interferometric scattering microscopy for mass spectrometry of single biomolecules in solution. The PoC grant will be used to produce a near-market ready prototype and implement the required software modifications expected of a commercial device, to demonstrate that the technology is sufficiently robust to warrant venture capital funding for our spin-out company. Our early discussions with both pharma and instrument manufactueres have highlighted a need for more in-depth application of our technique. The novelty of our approach requires both demonstration and testing on a broad range of potential analytes and environments, which is why we require a portable instrument, that not only enables on-site testing, but also on-site demonstration in a non-university research environment. Similarly, there is a clear and pressing need to produce more intuitive and clearly commercially viable software to unlock the full potential of our technology. Data from these experiments will help define our final product(s) and to translate this research into a viable package for raising venture capital. The development of a novel, broadly accessible technology enables new avenues for screening potential drug candidates that could be used to further our understanding of drug interactions at the molecular level. The economic benefits will, therefore, be realised primarily through the pharmaceutical, healthcare and allied industries as well as the bioanalytical industry, through increased sales of instruments. All will have a considerable impact on the European economy. In addition to drug-discovery-related advances, our technology has the potential to transform cholesterol classification and change current approaches to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Revealing Sources of Gendered Parenthood: A multi-method comparative study of the transition to parenthood in same-sex and different-sex couples', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project is the first to apply an inclusive, internationally comparative, multi-methods approach to families to reveal the complex processes that result in a gendered division of work. We do this by comparing different-sex couples (DSC) to same-sex couples (SSC) focusing on the transition to parenthood and its career related consequences based on unique, population register data, census data and surveys, as well in depth interviews with couples. Three sub-projects emerge. In GENPARENT NORTH, longitudinal analyses of register data for the full population in the Nordic countries enable unique studies of the division of work and care in DSC and female SSC in a most similar-case comparison where the couples are matched on important background characteristics. In GENPARENT REGIME, the Nordic countries, the Netherlands and the US are compared in cross-sectional, quantitative analyses of female and male SSC and DSC with biological or adoptive children, their division of paid/unpaid work and the resulting career trajectories. Preliminary analyses indicate that family leave policies apply to some but not all families and this clearly structures the division of work and earnings in them. In GENPARENT VOICE, in-depth interviews with female and male SSC (planning for or having children) and adoptive DSC parents are carried out in order to explore the reasoning and expectations that precede the realized divisions of child care and paid work. In addition, the legal and social issues facing these families is highlighted. Interviews are conducted in Sweden and the Netherlands and for these countries, we have unique, longitudinal in-depth interviews with DSC expecting and having their first child. By comparing SSC to DSC and combining cross-sectional and longitudinal quantitative an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Real Time Wide Area Radiation Surveillance System' (REWARD).

assistant: **Concept**

We propose a novel mobile system for real time, wide area radiation surveillance. The system is based on the integration of new miniaturized solid-state radiation sensors: a CdZnTe detector for gamma radiation and a high efficiency neutron detector based on novel silicon technologies. The sensing unit will include a wireless communication interface to send the data remotely to a monitoring base station which also uses a GPS system to calculate the position of the tag.The system will also incorporate middleware and high level software to provide web-service interfaces for the exchange of information, and that will offer top level functionalities as management of users, mobile tags and environment data and alarms, database storage and management and a web-based graphical user interface. Effort will be spent to ensure that the software is modular and re-usable across as many architectural levels as possible. Finally, an expert system will continuously analyze the information from the radiation sensor and correlate it with historical data from the tag location in order to generate an alarm when an abnormal situation is detected.The system will be useful for many different scenarios such as nuclear terrorism, lost radioactive sources, radioactive contamination or nuclear accidents. It will be possible to deploy in emergency units and in general in any type of mobile or static equipment, but also inside public/private buildings or infrastructures. The sensing units will be highly portable thanks to their low size and low energy consumption. The complete system will be scalable in terms of complexity and cost and will offer very high precision on both the measurement and the location of the radiation.The modularity and flexibility of the system will allow for a realistic intro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantification of pollutant dry deposition Fluxes over Mediteterranean typoe ecosystems' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

To continue and extend the work initiated successfully with SREMP Surface Resistence Emergency Measurement Program" at a larger variety of ecosystems situations, including in the measurements pollutants such as NOx and HNO3 which have an important role in the acidification and eutrophication of European ecosystems. Anthropogenic air pollutants are transported at long distances in Europe affecting rural ecosystems by direct  attack of oxidants such as ozone on vegetation and through deposition of acidity and nutrients. The application  of the critical loads concept to assess the effects of air pollutants and to the management of air quality in Europe  requires the precise knowledge of dry deposition processes and mechanisms in order to preview with certainty  transportation from emission sources and deposition over the different European ecosystems.  During BIATEX Workshops it was recognised that a large amount of data has been gathered during last years  for Europe which resulted in a better and more accurate parameterisation of dry deposition fluxes, but also that  an almost complete lack of information still exists concerning dry deposition for conditions prevalent in South  Europe, completely different from northern European regions, with extensive periods of dry and warm weather  which result in drying and dying of herbaceous vegetation during Summer. Parameterisation of dry deposition  processes, developed with flux measurements taken in northern Europe have to be tested for these different  ecosystem characteristics, before its application in long range transport models and the preparation of dry  deposition maps can be done with confidence. Measurements taken along extensive periods in SREMP, in  1994/1995 will give valuable but incomplete information concerning