RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Age-modified forms of Amyloid-β as initiator of Alzheimer Disease pathogenesis and mediator of Aβ-tau interaction: a study in a Drosophila model and Aβ immunized human Alzheimer patients' in the context of a Seventh Framework call.

assistant: **Objectives**

Alzheimer Disease (AD) is the commonest form of dementia, with ageing as the main risk factor. There are currently over 6 million people with dementia in the European Union (EU). The increasingly ageing population makes AD an economic and social burden for our society, thus investigating the pathological mechanisms of AD and the characterization of the pharmacological targets are research priorities. Aggregation of amyloid-Beta (Aβ), upstream of tau phosphorylation, is considered a driving force in AD pathogenesis, and the major target of the clinical trials of immunotherapy. The first clinical trial at Southampton University (UoS) showed Aβ removal but also reduced phospho-tau, supporting a link between these proteins. Similar evidence emerged in bigenic tau/Aβ Drosophila, a neurodegeneration model. During ageing in humans, the molecules of AD pathogenesis undergo ageing processes resulting in amino acid modifications that influence protein folding, functionality and interactions. Specially, pyroglutamate-modiﬁed Aβ (pEAβ) seems to be a key participant in AD pathology. Accordingly, the identification of markers of protein ageing is important to comprehend AD pathogenesis with relevance in therapies. Indeed, Aβ immunotherapy did not improve the cognition in the treated patients, potentially due to the absence of clearance of aged-modified Aβ implicated in pathological pathways. I propose to exploit the bigenic tau/Aβ drosophila to determine if pEAβ increases with ageing, driving AD pathogenesis; and whether pEAβ is the major Aβ form mediating Aβ/tau interaction. Taking advantage of the unique cohort of human unimmunized and immunized AD brains at UoS, I will investigate if pEAβ formation and its interaction with tau have been modified by Aβ immunotherapy. The results wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissemination of external costs of electricity supply - making electricity external costs known to policy-makers (MAXIMA)' (MAXIMA), addressing dissemination and exploitation.

assistant: **Impact**

Quantification of externalities from electricity production has made considerable progress, however, internalisation of external costs has not been implemented broadly, due to lacking information on the concept and its application as policy aid. Even though the Impact Pathway Approach (IPA) developed in Extern is accepted as the best way to calculate energy external costs, results show considerable uncertainties and variations with different basic assumptions in certain areas. The scientific task of reducing uncertainties is currently addressed in several projects; identifying the assumptions to be used for decisions however requires consensus with stakeholders. The main objective of this project is to translate and present the concept of externalities, the quantification approach and results outside the scientific community. Furthermore, a discussion of pros and cons between representatives from energy industry, policy and NGOs will be initiated with the aim of reaching a consensus on methodology and values. A concept for internalisation of external costs in the electricity production sector is developed, and aggregated values as required by the internalisation instruments are derived with the IPA. In two workshops with stakeholders from NGOs, policy and energy industry approach, values and internalisation instruments are presented and pros and cons as well as possible reservations are discussed. Based on the discussions, arguments to overcome reservations are exchanged and suggestions for converging opposing standpoints are made. Thus prepared, a third workshop is held with the aim of reaching consensus as far as possible. Issues on which no consensus can be reached are documented, and implications of diverging views on values as well as conclusions and decisions are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next generation gene writing platform to cure genetic and oncological diseases' (FiCAT), addressing dissemination and exploitation.

assistant: **Impact**

Gene therapy offers a promising opportunity for treating the more than 10,000 human genetic diseases, as well as other disorders, such as cancer, by editing disease-causing genetic defects or engineering immune cells to target cancer cells. However, most genetic disorders remain untreatable, as gene therapy still holds an untapped potential due to significant limitations of current editing technologies, that are not efficient, precise and safe enough and thus, present limitations in scope and applicability. Integra Therapeutics, a spin-off of the Pompeu Fabra University (UPF) has developed an advanced genome writing platform that overcomes the limitations of current gene editing technologies. Our proprietary gene writing technology platform- FiCAT combines the precision of RNA-guided nucleases with the effectiveness of programmable transposases to insert large pieces of DNA in a safe, precise and stable way. FiCAT has the capacity to integrate virtually any gene into the genome with unprecedented efficiency, precision and safety. FICAT has already been validated in several ex vivo and in vivo models. With FiCAT, we will unlock the potential of gene writing to cure genetic diseases and bring life-changing therapies to patients suffering from high unmet need genetic and neoplastic diseases.


**Keywords:** Transposases, nucleases, large therapeutic payloads, gene writing tools, genetic diseases, PFIC2, gene editing, CRISPR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart Technologies for the Conversion of Industrial Lignins into Sustainable Materials' in the context of a Horizon 2020 call.

assistant: **Objectives**

SmartLi aims at developing technologies for using technical lignins as raw materials for biomaterials and demonstrating their industrial feasibility. The technical lignins included in the study are kraft lignins, lignosulphonates and bleaching effluents, representing all types of abundant lignin sources. The raw materials are obtained from industrial partners. The technical lignins are not directly applicable for the production of biomaterials with acceptable product specifications. Therefore, pretreatments will be developed to reduce their sulphur content and odour and provide constant quality. Thermal pretreatments are also expected to improve the material properties of lignin to be used as reinforcing filler in composites, while fractionating pretreatments will provide streams that will be tested as plasticizers. Lignin is expected to add value to composites also by improving their flame retardancy. The development of composite applications is led by an industrial partner. Base catalysed degradation will be studied as means to yield reactive oligomeric lignin fractions for resin applications. The degradation will be followed by downstream processing and potentially by further chemical modification aiming at a polyol replacement in PU resins. Also PF type resins for gluing and laminate impregnation, and epoxy resins will be among the target products. Full LCA, including a dynamic process, will support the study. The outcome of the research will be communicated with stakeholders related to legislation and standardisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unraveling key genetic innovations behind the emergence of the root-nodule symbiosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Today's world relies on usage of man-made inorganic nitrogen fertilizer. It is estimated, that 48% of the world's population could only be sustained through application of the nitrogen fertilizer. However, use of nitrogen fertilizer has profound multiple negative effects onto environment and human health. Therefore,  development of the improved crops, which can use atmospheric nitrogen as a direct source of N and, therefore, do not rely on fertilizer has became the European and Global political priority. Atmospheric N2 is the largest reservoir of nitrogen on Earth, but it is unavailable to most of the land plants. However, a few plant species (mainly legumes) evolved an ability to form symbiosis with nitrogen-fixing bacteria and use atmospheric nitrogen as the primary source of N. The idea of transferring so-called root-nodule symbiosis to non-symbiotic plants has first appeared in the 1970es, when close to nothing was known about the molecular pathways behind nodulation. A significant international research effort over the past decades has resulted in unraveling the key genes involved in root nodule symbiosis in a number of legume model plants. Surprisingly, most of the discovered symbiotic genes were also found in non-symbiotic plants, making it difficult to elucidate key evolutionary innovations responsible for emergence of symbiosis. However, a long-needed detailed comparative study between nitrogen-fixers and non-fixers was not possible until now. The availability of completely sequenced plant genomes of species with nodal positions within and outside the nitrogen-fixing clade gives me the unique opportunity to compare the key symbiotic regulatory network in symbiotic and related non-symbiotic plants and elucidate which genes, regulatory connections or cis-regulato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'COFUND Fellowships for Transnational Academic Careers' to be submitted under Seventh Framework.

assistant: **Abstract**

The ‘BREMEN TRAC – COFUND Fellowships for TRansnational Academic Careers’ programme will enable incoming researchers to conduct an independent research project in a highly competitive and vibrant research landscape. With no thematic restrictions, research topics and hosting institutes at the University of Bremen can be freely chosen.BREMEN TRAC explicitly targets excellent researchers residing outside Germany and offers two-year fellowships with a standard salary and an additional research allowance to early stage postdocs. In addition, international TRAC fellows coming to Bremen will avail themselves of a broad range of support measures testifying to Bremens reputation as a talent incubator.BREMEN TRAC can capitalize on experiences with our own  long-established and  highly competitive postdoctoral programme: Selection committees and judgement criteria based on merit are already in place and administrative procedures will be easily adapted. External peer review already is a crucial element in the selection of the fellows.The existing programme has considerably been extended in scope two years ago. However, it has always been geared towards national applicants. BREMEN TRAC will offer nearly as much additional positions, but  explictly to international researchers. This will contribute to fostering transnational mobility of highly promising researchers in the ERA at an early career stage.TRAC Fellows will greatly benefit from being integrated in a dense interdisciplinary research network with the University of Bremen at its center, offering stimulating research to connect to.   Furthermore the university campus offers them  ample opportunities for engaging in research cooperations with non-university institutes of excellence, e.g. including institutes of the Max Planck S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Intelligent Sensor Network and System Technologies for Fish Farming'.

assistant: **Concept**

Fish farming is likely to be the greatest source of increased fish production, and its share in total food fish supply by 2030 is estimated almost equal to the food fish supply from capture fisheries. Intelligent monitoring and control system for fish farming generates labor and energy savings, limit disease and mortality, and increase yields by continuously monitoring and controlling water quality.The main objective of SENSORFISH joint research programme is to increase mobility and exchange of researchers between EU countries and China，US to obtain better understanding of intelligent sensor network and system technologies for fish farming. This program will focuses on four areas: 1) Smart Sensors for fish farming; 2) Wireless sensor network for fish farming; 3) Remote control and management system for fish farming; 4) Integration of fish farming system. An intelligent monitoring and control system for fish farming will be pilot used and tested in Norway and China. The results of these contributions will be made available to the academic community, and research conclusions drawn will be published in international journals. In these Staff Exchanges each participant will also seek to share their knowledge within their area of expertise by organizing training seminars, courses for early stage researchers also involving local, regional and/or national management agencies according to their needs or demands.SENSORFISH programme builds a basis for long-term collaboration among participants and  will exploit complementary expertise of the participant organizations and participants in order to create synergies among participants and to establish long-lasting partnership. As multi- and cross-disciplinary studies essential in intelligent sensor network and system technologies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Consumer-oriented access to media content' (CONTACT).

assistant: **Concept**

The CONTACT project addresses the societal and technological problems faced by consumers due to vastly increasing amounts of audio and video content. Technological developments are leading to dramatically increased storage capacities of multimedia devices used in the home as well as large increases in the bandwidth of Internet connections and broadcast channels. These developments pose great problems for the consumer in terms of selecting, archiving and retrieving content. They also pose a challenge for the consumer electronics industry in that, so far, no solutions have been realized for consumer devices to overcome these problems. The CONTACT training project investigates solutions to enable users to more easily manage their content and search for specific content. It is based on the cooperation between researchers from diverse scientific disciplines, ranging from machine learning to human factors. The CONTACT training project provides positions for four postgraduates with a background in these discipline s and a strong interdisciplinary orientation. The fellows will get the chance to receive first-hand training expertise from one of the leading private research organizations in Europe. The overall aim of CONTACT is to learn how to preserve and extend the convenience for the user in a situation of multimedia overload due to seemingly unlimited digital information. Each fellow will execute research in a scientific and technologically high-qualified environment under the supervision of a senior scientist. There will be close exchange between fellows in order to maximize the benefit of their complementary expertises. The fellows will have ample opportunity to contribute to and participate in activities of the scientific community. The training projects will serve the cor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantifying electron-electron forces at the atomic scale'.

assistant: **Concept**

Quantum phases of matter in novel 2D materials host fascinating correlated electron properties, such as unconventional superconductivity, novel insulating phases and exotic magnetic order. These phenomena are a hotbed of new forms of energy-efficient technologies, which require fundamental understanding and exploration of these material classes. Since the beginning, scientists have been struggling with the puzzling lack of consistent predictability of such materials, leading predominantly to serendipitous discoveries. The key ingredient driving these exotic quantum phases are electron-electron interactions, so-called correlations. These correlations between the electrons play a prominent role in their movement, and often result into atomic-scale charge and spin order, and are amplified in 2D materials compared to their 3D counterparts. Owing to the 2D nature, a new state-of-the-art methodology is needed to elucidate the electronic and magnetic properties in correlated 2D quantum materials.   DeQ investigates the role of electron correlations and their interplay with structural and spin degrees of freedom at the single-atom level in insulating quantum phases of novel 2D materials. To accomplish this aim, my innovative strategy is to quantify atomic-scale charge and spin order at transitions between different quantum phases in three classes of hallmark 2D materials: twisted bilayers, correlated quasi-2D compounds, and 2D magnetic materials. My novel approach is based on creating a new state of the art in atomic imaging and spectroscopy, the JAQ setup. The development of JAQ will enable us to precisely tune relevant parameters, like electric and magnetic fields, in the highest-quality materials available. The outcome of DeQ will be groundbreaking for predicting electron co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Holistic management practices, modelling and monitoring for European forest soils'.

assistant: **Concept**

Knowledge gaps on forest soil processes and lack of a harmonised soil monitoring limit the EU’s ability to maintain soil related ecosystem services and to reach climate policy targets. A better understanding of the soil processes and a harmonised approach to manage and integrate data to computational models that are used for decision making is urgently required in order to meet climate and sustainability goals, including the UN's Agenda 2030 SDGs, the Paris Agreement of Climate Convention, the EU Bioeconomy Strategy, the EU's LULUCF Regulation, the EU Forest Strategy (2018), and the European Green Deal. HoliSoils will develop a harmonised soil monitoring framework and identify and test soil management practices aiming to mitigate CC and sustain provision of various ecosystem services essential for human livelihoods and wellbeing. HoliSoils incorporates novel methodologies and expert knowledge on analytical techniques, data sharing, soil properties and biodiversity, and processes with model development, in order to develop tools for soil monitoring, refine GHG assessment of the LULUCF sector, enhance efficiency of GHG mitigation actions, and improve numerical forecasting of soil-based mitigation, adaptation, and ecosystem services. HoliSoils applies a collaborative multi-actor approach, in order to maximise its applicability and impact beyond its duration. The multidisciplinary consortium consists of universities and research institutes from across Europe, with leading expertise on soil analysis and databases, development of advanced analytical techniques, complex system modelling, digital soil mapping, soil ecology, disturbance ecology, forest and GHG inventories, social sciences, and communications. It also involves active engagement with diverse stakeholders, includin