RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polymer Grating Sensors' (POGS), addressing dissemination and exploitation.

assistant: **Impact**

“POlymer Grating Sensors” (POGS) is a project that will significantly extend the range of application of silica optical fibre grating sensors by developing a mature version of the technology in polymer optical fibres, whilst at the same time forming a training environment for the fellow that is both interdisciplinary and intersectoral. Polymer fibres offer some significant potential advantages over silica, the two most important perhaps being the ability to sense much higher strains – as may be encountered in modern composite materials - and the considerably reduced stiffness of the plastic compared to the glass fibre. Polymers are however complex materials and the properties of a polymer grating sensor are dependent on the sensor fabrication process.This project places the fellow at the centre of a collaboration between two key groups in this field. The host, Dr. DJ Webb, heads a team who are the world leaders in polymer fibre grating fabrication. The fellow will also spend several months at the Technical University of Denmark, who are at the forefront of microstructured polymer fibre fabrication particularly relating to fibres based on TOPAS cyclic olefin copolymer. In 2011 this collaboration produced the first grating sensors in TOPAS fibre and have shown that these devices do not display the sensitivity to humidity that is a problem with the usual fibres based on poly(methyl methacrylate).This timely project gives the fellow the opportunity to explore and develop this brand new fibre technology for long term, high strain sensing, producing optimised, repeatable and reliable grating sensors and develop new applications whilst undertaking research with industrial collaborators (Dr. Peter Foote - BAe Systems, Dr. Kate Sugden – Astasense Ltd) who will provide an industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Adapting Breast Cancer Screening Strategy Using Personalised  RiskEstimation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

While early detection of breast cancer by screening appears effective, many women derive little or no benefit from screening, due to the way it is currently organized: as a one-size-fits all approach irrespective of personalised risk factors. It is known, however, that some women are at a much higher risk of getting the disease than others, and that mammography is unsuitable for cancer detection in women with dense breasts. The aim of this project is to develop personalised methods to tailor breast cancer screening to the individual needs of the woman. We will propose methods to stratify women at the highest risk to MRI; those with intermediate risk and/or dense breasts to follow-on ultrasound. A risk model will be developed that includes both breast cancer risk and the risk of missing cancers in mammograms. In this model, breast density plays a key role, as one of the largest known risk factors and the factor making mammograms ineffective. Two SMEs focusing on breast density are involved, where academic partners bring unique databases with over 80,000 screening mammograms and associated risk profiles. These are essential for model development, and subsequently for the development of products that benefit all women. Personalised screening is only economically feasible if it is based upon cost-effective strategies. While current methods in breast MRI imaging and breast ultrasound are promising, more efficient protocols must be developed to use these modalities routinely in screening. With leading SMEs and clinical partners, screening procedures will be optimized by developing automated image analysis tools to guide workflow and quality assurance. More efficient MRI protocols will be investigated to reduce time and cost, while the use of novel MRI imaging sequences withou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of molecular events triggering the cytosolic enrichment of SUMO activating enzyme and its implications in seed quality.' (SUMOCell), addressing dissemination and exploitation.

assistant: **Impact**

Post-translational modifications by SUMO (Small Ubiquitin-like MOdifier) modulate protein activity through regulation of subcellular localization, protein activity and stability, and protein-protein interactions. In plants, SUMO is essential during seed development, modulates hormone signaling, and biotic/abiotic stress responses. Several studies point to a nuclear enrichment of SUMO conjugation machinery, which is consistent with a preferential nuclear localization of the SUMO targets. Nonetheless, non–nuclear targets exist and the molecular mechanisms that mediate their modification remain elusive. Dr Lois’s group has uncovered a novel regulatory mechanism consisting of the processing of the C-terminus of the SUMO E1-activating enzyme large subunit, SAE2. Processed SAE2 partially localize to the cytosol and the processing activity is prominent at the transition between embryo growth and seed maturation. Accumulation of SAE2 in the cytosol promotes cytosolic SUMOylation and behave as a signal for growth arrest, suggesting that SAE2 processing could contribute to finalising embryogenesis. SUMOCell aims to uncover the signals that trigger SAE2 cytosolic localization and the cellular responses activated by cytosolic SUMOylation. First, with Duke University partner, we will study SAE2 subcellular dynamics using super-resolution microscopy, under hormone treatments and stress challenges. Second, we will study the physiological processes regulated by SAE2 localization to the cytosol. For that, we will perform single-cell RNAseq studies from cells enriched in cytosolic SAE2. Bioinformatics analysis will be carried out by a placement at Sequentia SL. Finally, we will analyse physiological parameters related to seed quality. Data obtained from cell studies, transcriptomics and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fe complexes for Reduction/Oxidation Catalysis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Fe-RedOx-Cat project aims to introduce a new family of efficient, robust and selective iron-based electro-catalysts for both, CO2 reduction and H2O oxidation. Taking into account the detrimental environmental effect of CO2 (global warming), the development of new technologies for its valorization (for instance conversion to fuels) is becoming mandatory for our society. The target catalysts prosposed in the Fe-RedOx-Cat project are based on N-heterocyclic carbenes (NHCs) as ligands, which matches perfectly with the research background of the candidate. During the first part of the project at the University of North Carolina at Chapel Hill (USA), the researcher will learn a wide range of electro-analytical techniques for the characterization/optimization of the new catalysts and also for its mechanism elucidation. Later, the new acquired skills will be transferred to the host group in Europe at ICIQ (Spain). This group will also provide his expertise in the development of catalysts based on first row transition metals and mechanism elucidation by means of experimental techniques and computational methods. The afore-mentioned features of the applicant and the host groups will provide an outstanding synergy between all the participants. Hence the researcher will embark on a challenging work plan, learning new concepts in electro-catalysis and first row transition metal catalyst design, essential for the development of the project. Moreover, the Fe-RedOx-Cat project will provide to the applicant an excellent training in the multidisciplinary research area of CO2 valorization. Altogether, the Fe-RedOx-Cat project will enhance multiple competences of the researcher on scientific and transferable skills, thus stimulating his evolution as a scientist and contributing to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of an efficient technique for the reduction of waste in sheeting dough processing in the baking industry' (REDUXDO).

assistant: **Concept**

Current dough-sheeting process produces up to 30% of waste (The mass of waste is of 20% order of the end-product produced). The average cost of waste is €100/tonne (including landfill or incineration tax, administration, transport and raw material cost). Such high cost has burdened the industry greatly, and SMEs are particularly vulnerable to further increase of landfill tax. In response to the competitiveness of SMEs in this sector, our client is looking for an innovative technology to keep waste to minimum or ideally, zero. The project aims to develop an efficient technique to reduce waste in sheeting, stamping or roller-cutting of dough processing in the baking industry by 25%. By using tessellated roller-cutter with features, morphology of dough can be manipulated. Pieces of hexagonal dough are reshaped into desired forms (round or oval). This process will be adaptable to current manufacturing plants and aim to reduce waste to less than 5%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Building Research Excellence in Russian and East European Studies at the Universities of Tartu, Uppsala and Kent' in the context of a Horizon 2020 call.

assistant: **Objectives**

The goal of the project is to increase research productivity and excellence and to promote international visibility and integration of three European universities – Tartu in Estonia, Uppsala in Sweden, and Kent in the United Kingdom -- in the field of Russian and East European Studies by creating a dynamic, comprehensive, open and sustainable framework for cooperation and transfer of knowledge. In line with the objectives of Twinning, the aim of the project is to reduce the existing gap in scientific and innovation performance between the high-performing (UK and Sweden) and low-performing member states (Estonia). The work plan envisions the launch of an ambitious new academic conference series, the organization of five international summer and winter schools, extensive inter-institutional mobility, joint supervision of doctoral students and postdoctoral fellows, coordinated promotion of research outputs, joint conceptualization and launch of new collaborative research projects, as well as extensive dissemination and communication measures. The expected impact of the project is a significant improvement in the overall scientific capacity of the University of Tartu in the field of Russian and East European Studies, measured in terms of high-impact publications, external research funding, and integration into relevant international research networks. Due to the regionally leading position of the coordinating institution, as well as the open and inclusive approach chosen by the consortium, the project is expected to make a significant contribution to spreading excellence in the entire Baltic region and post-communist Europe more broadly.


**Keywords:** Regional Studies, International Relations, Comparative Politics, Russia & Eastern Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative Algorithms for Applications on European Exascale Supercomputers' (Inno4Scale) under Horizon Europe.

assistant: **Objectives**

New architectures for Exascale and post-Exascale computers will have massively parallel and heterogeneous processing capabilities that will require the complete redesign and reimplementation of the used algorithms to fully exploit the possibilities of these supercomputers. The objective of the Inno4scale project is to promote the efficient use of European HPC systems by identifying and funding the most promising novel algorithms for applications. Through this action, the project will facilitate the design and development of highly efficient application software for European Exascale computers, the most successful of which should later be taken up by science and industry, resulting in important performance gains. The project will design and implement a call for proposals based on the cascade funding mechanism, financing the most promising ideas on novel algorithms for applications to fully exploit and benefit from these valuable European Exascale resources. Proposals received will be evaluated by external experts based on their potential innovation and impact on the upcoming Exascale era, and the CASTIEL/EuroCC2 and PRACE networks will be used to ensure the widest possible reach of the call. The Inno4scale consortium, made up of two major European HPC research centres and two experienced partners in managing HPC-related programmes, is in the ideal position to carry out the project in an effective and efficient manner. The results of the selected innovation studies that will receive more than 4 million euros in total, include the development and publication of the novel algorithms to reduce the time-to-solution or energy-to-solution of existing computing problems, as well as to provide novel approaches for large-scale projects. In this way, the Inno4scale project will con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Adeno-Associated Virus Vector-Mediated Liver Gene Therapy for Crigler-Najjar Syndrome' (CureCN).

assistant: **Innovation**

Crigler-Najjar syndrome (CN) is a rare recessive disorder caused by mutations in the uridine diphosphate glucuronosyltransferase 1A1(UGT1A1) gene. CN is a life-threatening disease with no cure which constitutes a severe burden for the patients, their families, and the society. CureCN has the objective of developing a curative gene therapy for CN syndrome based on liver gene transfer with and adeno-associated virus (AAV) vector expressing the UGT1A1 transgene. Additional goals of CureCN are to develop strategies to allow for vector re-administration and to address the issue of pre-existing anti-AAV neutralizing antibodies (NAbs), which prevent large proportion of seropositive patients from receiving AAV mediated gene therapy. Proof-of-concept studies of AAV8-UGT1A1 gene transfer provide a strong rationale for the safety and efficacy of gene therapy for CN. CureCN proposes to carry out an open-label, multicenter clinical trial of AAV8-UGT1A1 gene transfer to prove the safety and efficacy of the therapy in severe CN patients, and file for marketing authorization in Europe at the end of the study. CureCN will also produce enabling data for the clinical translation of a groundbreaking immunomodulatory strategy to allow for vector administration. Additionally, a technology for the selective removal of anti-AAV NAbs from the bloodstream of seropositive patients will be developed. The goal of these studies is to ultimately allow all CN patients to access AAV8-UGT1A1 gene therapy. CureCN is a patient-driven initiative that gathers top clinicians and scientists; it also includes small medium enterprises in its partners, to foster economic growth and valorization of intellectual property. CureCN sets itself in the ambitious goal set by the IRDiRC by 2020 by developing a curative t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Emergence of communication in RObots through Sensorimotor and Social Interaction' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Starting from the assumption that cognition is embodied, the ROSSI project addresses the question how the possibility of communication between agents (e.g. humans and robots) is effected by differences in sensorimotor capacities.This is an important issue, given that robots are expected to become more common in non-structured environments, such as homes or hospitals. While there is a trend towards humanoid robots, it is clear that for the foreseeable future there will still be substantial differences in physical embodiment between robots and humans.To explore to what extent concepts must be shared to facilitate communication, we will build robots with sensorimotor systems structurally roughly similar to human beings. Furthermore, the control mechanisms for these robots will be based on insights into the neural mechanisms underlying human concepts and language.In particular, two types of neurons in premotor cortex will be modelled: (1) canonical neurons, which are active during both the execution of specific object-directed actions and the mere visual observation of the same objects, and (2) mirror neurons, which are involved in both an agent's own actions and the visual observation of such actions performed by others.In this framework, the project's aims are twofold. First, behavioural and neurophysiological experiments will provide new evidence and insights into the grounding of human conceptualization and language. Second, computational modelling of the underlying neural mechanisms will provide novel approaches to grounding of robotic conceptualization and language.More specifically, the project aims at building robots endowed with the sensorimotor and neural/computational mechanisms that allow them to: (a) flexibly manipulate and use objects in the environment, (b) u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Viral Genome Associated Proteome' (VGAP).

assistant: **Innovation**

The aim of this study is to analyze the comprehensive proteome associated with viral DNA. This systems biology approach that will combine functional proteomics and genomics has the name Viral Genome Associated Proteome (VGAP). It is based on a modification and refinement of the Hybridization Capture of Chromatin Associated Proteins for Proteomics (HyCCAPP) technology. All proteins associated with viral DNA, initially using Herpes simplex virus for proof of concept, will be cross-linked by paraformaldehyde treatment, the viral DNA will be selectively precipitated, and all proteins associated with the viral genome will be analyzed by mass spectrometry. The results will reveal all cellular and viral proteins that physically interact with the viral genome at a certain time and that are involved among others in regulation of viral genome structure, viral gene expression, DNA repair and cellular intrinsic immunity. The development of VGAP, a new method for the specific analysis of the viral genome-associated proteome will provide a new tool for the research of DNA viruses. In theory VGAP should be applicable to all DNA viruses, and we think it will be possible to analyze proteins associated with the DNA of all DNA viruses, so the entire field of virology should profit from the establishment of viral HyCCAPP. DNA viruses include important human pathogens like herpesviruses, human papillomaviruses and adenoviruses. A plethora of novel viral DNA-protein interactions will be discovered that will spark new research projects and can serve as new targets for antiviral therapy and vaccination strategies. Although beyond the scope of this proposal, so far unknown cellular proteins that are needed for efficient viral replication can be used for screening of small molecule libraries and