RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Maternal Organ Remodelling and Physiology during Reproduction: Role of the Mesentery'.

assistant: **Objectives**

Reproduction involves significant resizing of many maternal organs, including the intestine. While previous studies indicate that maternal gut growth supports offspring viability, contributions of surrounding tissues remain largely unexplored. The mesentery–a continuous, fan-shaped peritoneal fold anchoring the intestine to the body cavity–is composed of two layers of mesothelial cells encasing a complex stroma. Although essential during intestinal development, the adult mesentery is largely regarded as a structural scaffold and is rarely considered in the context of whole-body physiology and homeostasis. Intriguingly, the mesentery exhibits plasticity in adults during injury and disease, suggesting that its developmental potential can be reactivated by specific signals.While characterising the reproductive remodelling of the intestine, the host lab has observed that the surrounding tissues – including the mesentery – also grow. Building on these observations, I will investigate how the adult mesentery actively remodels during pregnancy and lactation and identify molecular signals orchestrating this process. Using mice as a model, histological and transcriptomic analyses will be combined to characterize region-specific changes in mesentery during female reproduction. Subsequently, the role of candidate genes or hormones in regulating mesentery resizing will be interrogated using ex-vivo mesentery culture and in vivo tissue-specific conditional knockouts. By characterising and understanding the mechanistic basis of mesentery reproductive remodelling, this work will provide the first detailed description of the murine mesentery and offer new insights into the plasticity and physiological role of this largely understudied organ.


**Keywords:** Organ plasticity, Mesentery,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Combating incontinence, from basic science to clinical practice' to be submitted under Seventh Framework.

assistant: **Abstract**

Incontinence affects almost 66 million people in the European Union. The Over Active Bladder (OAB) symptom complex is one of the major causes for incontinence, with a large number of affected persons and immense associated health care costs. The causes for the over active bladder contractions, underlying the urinary urgency of OAB are unknown, and current treatments are only partially effective. This collaborative and translational project, involving interaction between experimental and clinical urology scientists will focus on OAB and will characterize the different interacting cellular components and signaling systems in the wall of normal urinary bladders and OAB. The release of local mediators in the bladder wall, the properties of a newly described cell type (the interstitial cells, which may play a role in bladder over activity), the sensory signaling pathways (TRPV1-receptors), the receptor interaction and cellular communication are considered in order to create an integrated view on the mechanisms of bladder over activity. A strong emphasis is put on interaction between basic science and clinical applications, using a translational approach involving both specific animal models and human tissue from patients with defined urodynamic information. Several ethical and logistic issues with the use of human tissue are specifically addressed. An important further aspect of the experiments on human tissue is a direct analysis of the links between genetic and the urodynamic data of the patients, using unique biobanks. This will allow us further insight into the mechanisms of disease and possibly to identify new therapeutic targets. In close collaboration with a small company, we will develop an innovative potential physical therapy to affect bladder function. We will dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regulation of apoptosis in fibroblast-like synoviocyte by TNF-alpha and signal transduction activation in the process' (ARFTSA) under Sixth Framework.

assistant: **Objectives**

Hyperplasia of synovial membrane is a hallmark of Rheumatoid Arthritis (RA), and is associated with enhanced cytokine levels, which is also a character of RA. Synovial hyperplasia is mainly due to the fibroblast-like synoviocyte (FLS)'s over-proliferation and resistance to apoptosis. TNF-alpha is a primary cytokine in the development/progression of RA disease and is able to induce cell proliferation, activity and apoptosis. Clinicai experience has shown that anti-TNF-alpha therapy is effective without significant adverse effects. There has been some research in the field of TNF-alpha induced FLS proliferation, but few studies have been done about the regulation of apoptosis in FLS by TNF- alpha.The aim of our research is to study regulation of apoptosis in FL S by TNF-alpha and the mechanism underlying this process. Apoptosis is an active action in cells determined by the signal transduction initiated by different signals such as cytokines. TNF-alpha is a cytokine broadly associated with both survival and death signal transduction pathways, and we hypothesize that TNF-alpha may play a dual role in FLS's apoptosis: on the one hand, it can protect FLS from apoptosis through activation of survival signal transduction such as PI3K-Akt signal pathway, and on the other hand, it also triggers the activation of some death signal transduction such as Fas signal pathway possibly leading to cells' apoptosis after the block of survival signal pathway.TÚNEL (Terminal dUTP nick end labelling) assay and DNA laddering will be use d to identify apoptosis; cell viability will be determined by MTT assay; possible related signal factor expression will be measured by western-blot and RT-PCR on protein and mRNA level; electrophoretic mobility shift assay will be used to measure NF-kappa-B ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Identification of neo-vasculature markers and production of high-affinity recombinant antibodies for diagnostic and therapeutic applications'.

assistant: **Innovation**

Progression of solid tumours is accompanied by proliferation of newly-formed blood vessels ('neo-vascuLature), which supply the rapidly growing tumour cells with nutrients. Although present also in wound healing and fetal development, neovasculature formation is a characteristic feature of tumour growth. Neo-vasculature markers are thought to be among the best goals for tumour targeting therapeutic strategies. Optimal neo-vasculature markers have the following desirable characteristics: a) they are expressed in reasonably large quantity only by newly formed blood vessels b) they are expressed by neo-vasculature of a large variety of different tumours, and thus represent multi-purpose targets for several anti-cancer applications c) they are readily accessible to targeting agents, for example specific monoclonal antibodies labeled with a radionuclide, allowing a fast and specific delivery of toxic agents which may impair tumour cells viability. Neo-vasculature markers of excellent quality have recently been described by one of the Participants of our Project (Castellani, P., Viale, G., Dorcaratto, A., Nicolo, G., Kaczmarek, J., Querze, G. and Zardi, L. (1994) Int. J. Cancer 59, 612-618). The objectives of this Project are: 1) Isolate endothelial cells from human tumours. 2) Use the most advanced technologies in phenotype analysis such as computerised 2Dpolyacrylamide gel electrophoresis (2D-PAGE) and selection with antibody phage display libraries to identify novel good neo-vasculature markers and to evaluate their variability from patient to patient. 3) Produce high-affinity recombinant antibodies against neo-vascuLature markers using phage display technology. 4) Evaluate the performance of anti-neo-vasculature antibodies in immunocytochemistry and in vivo tumour targeti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ecocentric management for sustainable fisheries and healthy marine ecosystems' (EcoScope) under Horizon 2020.

assistant: **Objectives**

The EcoScope project will develop an interoperable platform and a robust decision-making toolbox, available through a single public portal, to promote an efficient, ecosystem-based fisheries management. It will be guided by policy makers and scientific advisory bodies, and address ecosystem degradation and the anthropogenic impact that are causing fisheries to be unsustainably exploited across European Seas. The EcoScope Platform will organise and homogenise climatic, oceanographic, biogeochemical, biological and fisheries datasets for European Seas to a common standard type and format that will be available through interactive mapping layers. The EcoScope Toolbox, a scoring system based on assessments of all ecosystem components, ecosystem and economic models, will operate as a decision-support tool for examining fisheries management and marine policy scenarios and spatial planning simulations. Groups of end-users and stakeholders will be involved in the design, development and operation of both the platform and the toolbox. Novel assessment methods for data-poor fisheries, including non-commercial species, as well as for biodiversity and the conservation status of protected megafauna, will be used to assess the status of all ecosystem components across European Seas and test new technologies for evaluating the environmental, anthropogenic and climatic impact on ecosystems and fisheries. A series of sophisticated capacity building tools (online courses, webinars and games) will be available to stakeholders through the EcoScope Academy. The EcoScope project will provide an effective toolbox to decision makers and end-users that will be adaptive to their capacity, needs and data availability. The toolbox will incorporate methods for dealing with uncertainty; thus, it wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AN OPEN WORKBENCH FOR MULTILINGUAL DOCUMENT CREATION AND MAINTENANCE' (APOLLO) targeting Fourth Framework.

assistant: **Abstract**

APOLLO is a preparatory action concerned with the creation and maintenance of documents in different languages in banking. Open to subsequent extension, the application will initially focus on banking courseware management and products marketing documents in French and English. Demonstration will involve integration of a processing system with facilties for parallel editing of the same text in different languages, a document version management module, and an area-specific machine translation module. There will be an emphasis on open design, enabling the integration of other tools and use of the system in common office environments.Progress Over the year APOLLO has successfully competed its three major tasks: - a market study covering the needs in the banking sector for a multi-lingual document authoring and management workbench, and, current market offerings. - a mock-up of a workbench for multi-lingual document creation and management. - specifications and a workplan study for a full fledged future workbench. Following the market study, and some unexpected findings, the specification phase was slightly delayed. The project will have to refocus the specifications and target a different sector than banking. Market Study STE, in close collaboration with ABB, IFBL and INIST, have studied the needs for multi-lingual tools of the banking sector in Belgium, France and Luxembourg. The results were then compared to the needs in the industrial sector. From the data collected, it is obvious that the banking sector has very specific needs and it seems that current technology cannot satisfy these needs. The needs for multi-lingual authoring tools in banks vary strongly, depending on the country. In Luxembourg these needs are almost non-existent whereas in Belgium and France their s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Public Debt and the Republic: Florentine Political Thought and Public Finance from 1470 to 1537' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The need to develop tools for the understanding of public finance has been highlighted by the financial crisis that broke in 2008. The research ambition of this project on the origins of political economy is to show that the intellectual history of public finance can generate such tools. Its main objective is to produce a monograph entitled *Public Debt and the Republic: Florentine Political Thought and Public Finance from 1470 to 1537*, which takes financial thought back to its roots, at a moment when the development of democratic institutions came to contradict the development of public credit. As such it also illuminates an understudied aspect of the political thought of the ‘Machiavellian Moment’, which redirected the tradition of classical Republicanism, thus defining one of the cornerstones of European modernity.This objective is achieved through:• exploitation of the Florentine archives. These preserve unique and unexplored materials which render feasible the in-depth reconstruction of the foundation of modern financial thought and practice• collaboration with the host institute. The Centre for the Study of the History of Political Thought (Queen Mary, University of London) hosts one of the largest concentrations of specialists in this field. The proposed investigation contributes to a central interdisciplinary research project of the Centre, on ‘Popular Sovereignty’.Undertaking the proposed project at the host institute allows the applicant to:• resume his European academic career after a five-semester hiatus researching and teaching in the USA and South Africa• further his career options in order to attain an academic position at a leading European institute• enhance his interdisciplinary skills, intertwining the history of ideas and the study of systems of adm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Extremal Combinatorics and Circuit Complexity'.

assistant: **Innovation**

Computational complexity theory is the systematic study of  computational problems in order to classify them in terms of their inherent logical hardness. Several decades of research have not only given rise to important understanding of limits of computation, but have also developed algorithms which constitute a crucial part of modern life. A formidable challenge in complexity theory is to show non-linear lower bounds for an explicit Boolean function. Our project is motivated by this fundamental problem and in fact we will approach several such questions motivated by understanding the complexity  of explicit Boolean functions. Our main objective look at circuit complexity through the lens of  extremal combinatorics, a rich and vibrant of branch of combinatorics which studies objects satisfying various constraints. Therefore we aim to develop a systematic methodology which adopts tools of extremal combinatorics to tackle complexity problems. More concretely we attack the problem of lower bounds for depth-3 circuits and specifically attempt to prove sharp lower bounds for the Majority function thus breaking a barrier in this area. We will further extend the techniques used in recent breakthrough on the Sunflower Conjecture and apply it to CNF formula and the structure of their satisfying assignments. We will our new insights on the structure of satisfying assignments to develop new improved algorithms for the satisfiability problem (SAT).


**Keywords:** circuit complexity, lower bounds, extremal combinatorics, satisfiability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Design of light-harvesting DNA-nanoprobes with ratiometric signal amplification for fluorescence imaging of live cells.'.

assistant: **Objectives**

The project is aimed to develop the novel technique of fluorescent signal amplification upon detection of RNA sequences in living cells up to a single copy level. The novel interdisciplinary approach will be focused on design of innovative fluorescent nanosensors based on polymer nanoparticles (NPs) incorporated with organic dyes, functionalized with DNA shell. The project is predicated on the innovative design of DNA-nanosensors, proposed by the Applicant, which is built on groundbreaking findings of the Host laboratory on ultrabright organic NPs and giant light-harvesting phenomenon that enable strong amplification in detection of nucleic acids. The project relies on contemporary spectroscopy/microscopy facilities and developments of the Host group, and the strong experience of the Applicant in synthesis of fluorescent dyes, design of DNA-probes and bioconjugation techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'dynamical complex systems'.

assistant: **Concept**

The program exchange concerns researchers in fundamental mathematics. The topic is the study of dynamical systems. Dynamical systems represent the mathematical way to study chaos. One of the sources of inspiration was the strange attractors discovered by meteorologists (the famous ""butterfly effect""). This exchange program concerns a large part of the European experts in that topic. As Brazil stands for the strongest country in dynamical systems, the aim of this programme is to allow a deep transfer of knowledge from Brazil to Europe and a long term cooperation between the best European researchers and their highly renown Brazilian pairs.  This exchange programme will give each researcher the opportunity to work in groups on their specific topics but also to benefit from knowledge developed in interconnected topics. To this purpose the project has been divided in the following three broad categories : Quasi-periodic dynamics, Hyperbolic dynamics and Bifurcation theory""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative Laser Solution for Cutting  Welding TWIP steel with Improved Performance' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Located in Scurzolengo, city with a high concentration of technology, robotics and automation companies,our Company, ELETTROSYSTEM SAS, is an expert for designing and building high technology solutions through assembly and testing process machines. Currently, ELETTROSYSTEM is one of the leaders in automation technology, with 17 products sold last year regarding special assembly machines, testing benches and complete process automatic lines production, where we obtained € 7.4 million turnover in the past year and we offer customized and dedicated solutions to our clients in most of the industrial fields, especially in automotive, aeronautical, energy and biomedical sectors. In addition, ELETTROSYSTEM has experienced an overall growth of 100 % in the last five years (from € 3.7 million to € 7.4 million turnover) thanks to the special relevance that our international expansion has starred, having presence in Germany, France, rest of Europe and North Africa, South America and Asia.TWIMP, is the stand-alone equipment for a complete cutting and welding process for TWIP steel. Our product does not only meet the finishing requirements but also will solve the other two current problems: -Cut and weld complex shapes (required for vehicle’s structural parts) by using a fiber laser head combined with a robotic arm and a CNC controller, which allows the possibility of moving the source to a precise position.-Reduce the total cost of the whole process by avoiding the use of filler material and making a final small and compact process machine (so power consumption will be reduced and no foundations would be required).