RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pax8 as a marker of Ovarian cancer Originating in the Fallopian tube' to be submitted under Seventh Framework.

assistant: **Abstract**

Epithelial ovarian cancer is a disease with grim prognosis and high-grade serous carcinoma (HGSC) is its most common subtype. Recent literature suggests that HGSC arises in the fallopian tube (FT) epithelium, rather then in the ovary, and metastasizes to the ovary early on in the process of transformation. This hypothesis is based, among other findings, on common morphologic and immunophenotypic traits between HGSC and the fallopian tube secretory epithelial cell (FTSEC). One of the shared markers between HGSC and FTSEC is the transcription factor PAX8. PAX8 is known to play a critical role in FT organogenesis and as we have shown it is highly conserved in HGSC. I propose to study the role of PAX8 in FTSEC and in HGSC, thereby establishing its role as an essential lineage marker.In Aim 1 I will investigate whether PAX8 is a critical factor in cells of the FTSEC lineage. For this purpose we will use PAX8 knock down in HGSC cell lines and immortalized FTSEC lines to reveal PAX8’s activity in benign and malignant cells. As part of this aim (Aim 1b) we will test whether BCL2 is a target gene of PAX8 and a direct mediator of PAX8’s anti apoptotic role in FTSEC and HGSC. I will then use expression profiling to suggest and validate additional mediators of PAX8’s activity, thereby defining additional serous determinants.In Aim 2 I will reveal the genomic binding locations of PAX8 in benign, non-invasive and invasive carcinomas. Towards this aim we will use our unique genetically engineered mouse model of HGSC arising from the FTSEC. We will study PAX8 as a model to ask whether a transcription factor lineage marker, which is conserved throughout transformation, preserves its DNA binding profile, its target genes and its transcriptional regulatory network.Taken together, the resu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low-dimensional and Non-autonomous Dynamics' (LDNAD).

assistant: **Innovation**

This research project aims at making significant contributions to the bifurcation theory for non-autonomous (i.e., forced or random) dynamical systems.Dynamical systems is a very active research field, with a plethora of applications in other areas of mathematics as well as the applied sciences. Many dynamical systems arising from real-world applications are forced (non-autonomous), that is, driven by some external system or noise. In recent decades, there has been steadily growing interest in the theory of non-autonomous dynamical systems, which was mainly motivated by applications in physics, biology, engineering, chemistry, economics, ecology and other disciplines.Mathematical modelling is used extensively in engineering, and the natural and social sciences and typically gives rise to complicated dynamical systems depending on one or several parameters. Fluctuations in these physical parameters can lead to qualitative changes in the behaviour of the system (when a parameter reaches a critical value), referred to as a bifurcation or critical transition, where a sudden change in the dynamics is observed.Bifurcations and critical transitions occur in a wide variety of applications including climate change, medicine, and economics, and the understanding of the dynamical behaviour of systems near bifurcation points plays an important role to control and attenuate the expected consequences.The main aim of this research project, is to develop insights and tools in order to complement the study of non-autonomous bifurcation theory. The proposal contains the following research directions:1. The development of a non-autonomous bifurcation theory for deterministic dynamical systems.2. The development of a general qualitative theory for forced monotone interval maps with transit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Personalized Prevention for Coronary Heart Disease' (CoroPrevention).

assistant: **Innovation**

European Coronary Heart Disease (CHD) burden is unsustainable. Better risk stratification tools and personalized care of patients are needed for reducing morbidity and mortality of CHD and the associated economic burden. To this end we have planned to shape and implement a personalized secondary prevention program for patients with established CHD. This precision strategy will be tested in a prospective trial, the CoroPrevention Trial, a central element of our proposal. We aim to significantly reduce the numbers of coronary events by using outcome risk- and patient characteristics- guided prevention in CHD patients.    1.            Prospectively evaluate clinical utility of personalized prevention in CHD 2.            Evaluate health economic and social benefits of the personalized prevention in CHD3.            Discover predictive markers of drug treatment response in CHD4.            Improve current ESC guidelines based on RCT validated clinical data 5.            Disseminate the refined prevention program to the attention of practitioners, patients, health care payers and policy makersThis program will establish a new economically sustainable personalized treatment practice applicable throughout Europe particularly to those regions where CHD prevention needs upgrading. The used protocols and technologies will carefully assessed by NICE using their standard evaluation methods that will allow independent expert opinions for different European authorities and decision makers. These opinion statements will further be supported by full Health Economics analyses of CoroPrevention Trial.


**Keywords:** Coronary Heart Disease, Secondary Prevention, Lifestyle, Exercise, Personalised Prevention, Biomarkers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Aquaponics from WAstewater REclamation' (AWARE) under Horizon Europe.

assistant: **Objectives**

AWARE sets out to increase capacity to produce fish for human consumption at KM 0 in every European city, with no impact on natural habitats, no dependence from natural freshwater availability, and high resiliency to climate changeThis goal could be met by farming fish locally using reclaimed water. Europe lacks the regulatory and policy framework to allow such a value chain to take root, due also to the absence of compelling scientific evidence of safety, quality, economic feasibility, and social acceptability.With AWARE, we want to remove the barriers preventing reclaimed water aquaculture from becoming a European reality. We will demonstrate seamless integration of our solutions in an aquaponic recirculation system (RAS) with IoT monitoring and automation technologies to improve its operation and overall sustainability metrics.  We will create the first European case study for reclaimed water aquaponics in the town of Fasano (Puglia, Italy), where we will leverage the results of a pre-existing H2020 project on advanced wastewater treatment. With the case study, we will-Demonstrate technical solutions for efficient and sustainable aquaponics from reclaimed wastewater-Increase the circularity of wastewater as freshwater resource to be exploited where it is generated-Create a new farm-to-fork value chain, contributing to European economic growth and to urban KM 0 farming-Lay the ground for a new regulatory and policy framework in support of European aquacultureThe project will go as far as conducting human intervention (i.e., feeding tests) on a panel of volunteers to obtain evidence of safety and quality of the produced food. In parallel, it will develop a sustainable business model and strategy for the for the future upscaling of the pilot solution, including its appl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The study of membrane phenomena caused by sphingomyelinase D from spider venoms' (ENZYMEMBRANE).

assistant: **Innovation**

Bites from the Loxosceles genus (brown spiders) cause several clinical manifestations in mammals, especially necrotic skin degeneration, hematological disturbances, and renal failure. These spiders have a world-wide distribution and accidents have been described in America, Europe, Asia, Africa and Oceania. The venoms of Loxosceles comprise a toxic component with a rare enzymatic activity, termed sphingomyelinase D (SMD). This enzyme catalyzes the conversion of sphingomyelin (SM) into ceramide-1-phosphate (Cer-1-P). While the enzymatic substrate SM is an integral constituent of many cell membranes, especially in the vascular epithelium and red blood cells, the reaction product Cer-1-P occurs in very low concentrations. Cer-1-P is suggested to be a novel lipid second messenger in cellular signal transduction events. At present, the precise mechanism of venom action is incompletely understood. This proposal describes a multidisciplinary strategy to explore the mechanism of SMD action at different molecular and supramolecular levels. To evaluate the effect of the interaction between SMD and biological membranes, model membrane systems of different compositional complexity will be used. This involves giant unilamellar vesicles as well as planar bilayers composed of relevant lipid mixtures and native biological membranes. Among others, state-of-the-art fluorescence techniques will be applied to directly visualize and spatially correlate the different events including biochemical (enzyme kinetics) and biophysical (membrane structure) aspects of enzyme action. This combinatorial approach will also explore enzyme/membrane interactions in relevant cellular systems, e.g., red blood cells and adipocytes. The proposed project implies extensive training of the fellow in a large vari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Macroeconomic modelling of R&D for the twin transition' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Macro-economic models are widely applied across the EU to support strategic planning for R&I and the green transition. However, these models do not include a detailed representation of R&I policies and do not explicitly model green technologies and the economic sectors that develop these technologies, the performance of R&D and its role in creating first mover advantages, monopoly rents, and eventually successful deployment of the green and digital technologies. To respond to these challenges, TWINRD aims to develop new data, technology matrices, models and enhance leading existing macro-economic modelling (GEM-E3 and NEMESIS). To this end TWINRD will develop innovative and interdisciplinary approaches for the enhanced modelling representation of R&I and innovation policy in EU-27 and improve the integration of R&I activities in applied macro-economic models based also on the collection, empirical analysis and integration of new data and technology matrices for green and digital technologies into the macro-models. TWINRD will develop a new innovative, open-source model specifically designed to address the Twin transition that goes beyond the standard approaches and will be both supply and demand driven. The advanced modelling tools will be used for the evaluation and assessment of R&I policy impacts on socio-economic and environmental indicators aiming to distil policy-relevant insights. All datasets, models and sets of software will be made freely accessible to stakeholders and the public in the TWINRD online platform and in other channels. The entire project will be based on active stakeholder interactions and inclusive dialogue to co-design the research and scenarios explored based on the creation of TWINRD open forum.


**Keywords:** advanced macro-economic modellin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Measuring Interstellar Reactions of Aromatics by Gas-phase Experiments'.

assistant: **Objectives**

The recent discovery of benzonitrile in a nearby cold molecular cloud (Taurus) marks the first detection of an aromatic species in the interstellar medium by radio astronomy. Benzonitrile provides a key link to benzene, which may be a low-temperature precursor to more complex polycyclic aromatic hydrocarbons (PAHs). Understanding the origin of PAHs will help answer fundamental questions about their role in forming interstellar dust as well as potentially prebiotic molecules—material that may be incorporated into new planetary systems. Computational models are used to pinpoint individual chemical pathways by inputting kinetic rates of various formation and destruction reactions and aiming to reproduce the molecular abundances determined by radio astronomy. Many of these rates have not been measured in the laboratory, especially at low temperature. The MIRAGE project aims to measure reaction kinetics of functionalized benzenes at temperatures relevant to the cold interstellar medium and use these measurements to understand radio observations of aromatics in Taurus molecular cloud. To do this, we will use a new technique in development at the Université de Rennes 1 that combines chirped-pulse (sub)mm-wave (CPMW) rotational spectroscopy with uniform supersonic flows generated by the CRESU technique. This apparatus (one of only a few in development worldwide) will be used to measure kinetics for reactions of benzene. These data are critical to accurately explain the observed abundance of benzonitrile, as well as predicting the abundances of other aromatic species currently targeted for detection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developments in maclane homology andre quillen homology and t-homology ofrings' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The domain of application of homology theories of algebras is very large. We have application in geometry, K-theory, algebraic topology. My primary interests are close to homological algebra and its applications. In particular there is an important interest to study MacLane homology for commutative rings as, recently, Pirashvili and Waldhausen have shown that is isomorphic with the topological Hochschild homology, which is related with problems in algebraic K-theory. In my research project, I will try to determinate, using algebraic methods of Franjou and Pirashvili, the MacLane homology for of further commutative rings. In parallel with this, I am interested, also in the F-homology, a new homology theory, introduced recently by A. Robinson at Warwick University. My aim when I finish my studies at Warwick is to return to Greece and to contribute to the development of these areas which are, at this moment, not well known there. Training content (objective, benefit and expected impact) Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Consortium Europe-Africa for Research and Innovation on Food Systems Transformation' (CEA-FIRST).

assistant: **Innovation**

CEA-FIRST, the Consortium Europe Africa on Research and Innovation for Food Systems Transformation, consists of 21 partners from Africa and Europe, partly from the former LEAP4FNSSA, extended with new public and private network partners. CEA-FIRST will operationalise the International Research Consortium (IRC) as a long-term platform on food and nutrition security and sustainable agriculture (FNSSA) in line with the FNSSA Roadmap of the AU-EU High-Level Policy Dialogue (HLPD). This IRC is a member-based, multi-actor platform and will work towards increasing synergies and coherence while reducing fragmentation and duplication of research efforts. Its aim is to promote higher returns on investments and impact on business development in Africa and Europe, by linking actors, research and innovation projects, initiatives, and funding programmes. CEA-FIRST will: 1. provide public access to a large knowledge platform, 2. offer a sound method for analysis of R&I activities, 3. support the updating of the FNSSA Roadmap, 4. establish operational working groups and thematic research calls. The final output will be a fully functional IRC, including governance bodies. CEA-FIRST will also support its liaison with the High-Level Policy Dialogue (HLPD). It will create a learning environment, including communication channels, to support multi stakeholder networks and to strengthen R&I coordination. The IRC will also serve related AU-EU policy priorities, such as the Climate Change and Sustainable Energy and the Innovation Agenda of the HLPD, as well as the European Green Deal priorities (and farm to fork strategy) and the AU priorities like the African Free Trade Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extension of shelf life and reduction of health risks for meat products by application of oscillating saturated steam' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Some kind of meat and meat products bear special risks of microbial infection leading to a reduced shelf life or even to illness and death. Therefore the number of pathogenic or spoilage bacteria on meat has to be kept low. The treatment of meat surfaces with steam offers a good solution but leads to disadvantages like e.g. colour changes of the treated surface. A new technique using oscillating saturated steam is promising to further improve the decontamination effects and to overcome these disadvantages. The objectives of the project are a log 4 to log 6 reductions of pathogenic bacteria and an extension of shelf life by 30%. Within the project the impact of the new technique on pathogenic and spoilage germs on the most endangered kinds of meat and meat products will be investigated. The SME-partners, a meat-finishing company, a pork-debunking factory and an equipment manufacturer will then work together on the development of an experimental machine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced Composite Integrated Skin Panelstructural testing' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Traditional aircraft structures use Aluminium stiffened panels for fuselage, wing and tail plane skins. In recent years stiffened skin panels are manufactured from composite materials instead of Aluminium. The use of composite materials has the potential to reduce aircraft weight, and therefore fuel consumption, and also to reduce maintenance and operational costs. Stiffened panels can be made by attaching stiffeners to a thin panel or by producing integrally stiffened panels, reducing costly assembly operations as well as composite machining operations which are costly and polluting. In this way, a composite stiffened panel has been developed as part of the JTI ""Eco Design"" technology demonstrator A2 with many ecological, technical and economical benefits.This proposal has two objectives. The first one is to perform a large scale test to validate the structural performance of the developed eco panel. The second one is to develop and validate an advanced measurement procedure based on distributed strain measurement systems. One of the main issues of the large scale tests is the strain measurement. Classic methods can only measure the strain in local positions. To obtain a quasi – continuous strain distribution a very dense grid of strain gauges or rosettes is necessary. Strain measurement with a large number of strain gauges and rosettes is a time consuming and expensive task that could be minimized with the use of distributed strain measurement systems.To fulfil the firs objective two eco panels will be tensile and compression tested in a MTS 2.5MN system. Text fixtures will be designed and produced according the interface areas previously defined together with the Topic Manager.For the second objective, two distributed strain measurement systems will be used: Photog