RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Flexible Manufacturing using Semantically Interoperable Data Integration'.

assistant: **Concept**

Every manufacturing enterprise and, in turn, its manufacturing systems, strive to produce at lowest possible cost, to perpetually enhance product quality, and to be able to rapidly respond to changing market demand. Existing manufacturing systems are not designed to meet the required market responsiveness neither at acceptable cost nor at reasonable speed. They are based on rigid production automation architecture designed to produce core products at high-volume and planned capacity in order to be profitable. Consequently, these systems cannot efficiently cope with variations in product demand. Why? To respond to demand change one must reconfigure production system, which is slow and expensive task for two main reasons: (a) reconfiguration is a complex task mostly done manually by highly skilled engineers and (b) it can take weeks to correctly adjust and tweak the largest systems and completing the task. As a consequence, the production systems cannot respond properly to changing market demands.When automation and robotization cannot cope with reshaped way of doing business, what can? Our solution should provide an answer. Namely, FlexInt enables the user of an automation system (for example Production Engineer) to autonomously execute the integration and reconfiguration of a production machine, e.g. industrial robot, without engaging teams of specialists, simply by applying his/her domain knowledge of manufacturing processes and of the machine. The rest is delivered by our Semantically Interoperable Data Integration, a set of digital platform and digital tools (applications), distinguished through their remarkable user experience and operational performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Shaping symbiosis in bio-based industrial ecosystems based on circular by-design supply chains' (SYMBIO).

assistant: **Innovation**

The SYMBIO project provides European regional communities with tools and methodological approaches to building bio-based business models based on circularity by-design and industrial symbiosis.Thanks to tools for integrating big data and artificial intelligence, SYMBIO shapes 10 symbiotic business models with high-profitability sustainability replicable at the EU level to increase bio-based products on the market and provides a system to modelling, measure and monitor symbiosis and its social, economic and environmental impacts. SYMBIO methodology will be designed, tested and validated in 12 EU pilot regions (Lombardy, Piedmont, Veneto, Friuli-Venezia Giulia, Emilia-Romagna, Carinthia, Slovenia, Croatia, Andalusia, Bruxelles Capital, Wallonia, Flanders) that have been selected based on the estimation of their bio-based resources defined by raw material availability, socio-economic indicators, intangible networks and infrastructures and potential for development of CBE close-to-market supply chains and current trends. Involving all supply chain actors in a quadruplex approach will help unlock and stimulate local development potential by promoting sustainable, innovative, tangible and participatory pathways to the green transition through an inclusive bottom-up CBE nexus.


**Keywords:** industrial symbiosis, biobased industries, value chains, artificial intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Othering the Renaissance. Conceptualizing Foreigners, Slaves and Infidels in in Early Modern Political Thought (ca. 1520-1610)'.

assistant: **Concept**

This research proposal studies how 16th century Renaissance Aristotelian authors theorized otherness and dealt with outcasts in their political works. The very idea of political community in early modern political philosophy is based on the view that, as stated by Aristotle in his Politics, some categories of people - women, foreigners, infidels, slaves, children  must be excluded from citizenship because they are considered ontologically different and, therefore, politically unequal. This makes some people outcasts of the political community and raises important questions: on which grounds are outcasts excluded from citizenship? What is their relationship to citizens? Which type of inequality does the exclusion of outcasts entail? Are there different forms of inequality at stake in the exclusion of others? OTHREN provides the first comprehensive study of how some 16th century Aristotelian thinkers theorized three figures of outcasts (foreigners, slaves and infidels) in their political thoughts and how this helped shape their ideas on such different minorities as Jews, Muslims and Amerindians. The proposal focuses especially on political works that were influenced by political Aristotelianism both in the humanist and scholastic traditions. These works are assessed against the backgrounds of Roman political thought (especially Cicero and Seneca), Roman law and the teachings of Christian anthropology that shaped early modern political thought.


**Keywords:** Renaissance Thought, History of Political Thought
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Wnt signalling and adipose tissue plasticity' to be submitted under Sixth Framework.

assistant: **Abstract**

Obesity resulting from hypertrophy of adipocytes is more deleterious metabolically than obesity resulting from hyperplasia of new adipocytes. Our aim is to understand the role of Wnt signalling network regulating the balance between hypertrophy and hyperplasic adipose tissue. We hypothesise that over nutrition activates Wnts regulatory mechanisms in adipose tissue to facilitate fat storage in pre-existing adipocytes or inducing differentiation of new adipocytes. Whereas overexpression of Wnts in preadipocyte s prevents adipogenesis, inhibition of Wnt signalling canonical pathway stimulates adipogenesis. Wnt signalling is also involved in the activation of proadipogenic transcription factors such as PPARgamma. Therefore our hypothesis is that Wnt network could control the balance between hypertrophy and hyperplasia in adipose tissue. The laboratory of my sponsor has characterised a PPARg2 Knock-out mouse showing hypertrophic changes in the adipose tissue of these mice in response to a high fat diet. In this proposal, I will use this model to investigate the role of Wnts in adipocyte hypertrophy or hyperplasia in vivo. In parallel I will also be able to learn the technology to generate a knock in mouse model of the first human mutant in a wnt related molecule detected in an obese subject. The specific objectives are: a) To identify genes from Wnt signalling network involved in adipocyte hypertrophy/hyperplasia using adipose tissue from PPARg2 KO using a Systems Biology approach involving gene expression profiling a nd advanced bioinformatic analysis. b) To characterise in vitro the role of Wnts signalling proteins identified in a) using gain and loss of function (RNAi) experiments. c) To generate and characterise a knock-in mouse expressing a non-functional human wnt 10 m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SYNERGISTIC USE AND PROTECTION OF NATURAL RESOURCES FOR RURAL LIVELIHOODS THROUGH SYSTEMATIC INTEGRATION OF CROPS, SHRUBS AND LIVESTOCK IN THE SAHEL' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The overall objective of SustainSAHEL is to enhance the resilience and intensification potential of smallholder agricultural farming systems to climate change through scalable innovations on crop-shrub-livestock (CSL) integration. SustainSAHEL aims to develop CSL systems through innovation platforms (IPs) in order to improve productivity and farmers’ income. We will assess adoption and scaling potential of improved CSL integration, while simultaneously optimizing proven technologies, improving herder-farmer cooperation, tackling socio-economic constraints for adoption and contributing to local economic revival. Our approach is embedded within the production systems of agro-ecology and organic agriculture, while comprising elements of conservation agriculture. Investigations on CSL, as well as soil quality and hydrology will be conducted through on-station and on-farm experiments and demonstration plots. We will identify drought resistant shrub teams that are in synchrony with livestock requirements, and reduced tillage options that enhances the soil water capture and holding capacity. At the regional level, landscape modelling scenarios will analyse the promoted systems’ resilience to climate change in West Africa. Dissemination activities will respond to the identified needs of youth and women and shall assure effective scaling of successfully tested innovations beyond the targeted regions. Systems approaches are a core concept of SustainSAHEL and reflect the linkage of biophysical, socio-economic, cultural and political realities. The project examines long-term economic support to local communities and improvement of agricultural practices through close cooperation with farmer organisations. Working closely with existing Africa-Europe networks and programs, the establ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conditioned container unit for haccp-safe transport and storage for provisions.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Transporting conditioned foodstuffs causes more and more problems. Variety in different conditions of the goods increase enormously. Lorries are getting complex, constructed, but HACCP standards are difficult to keep. Drivers are physically getting overtaxed, walking in and out temperature differences all day long. Neighbourhood complains about noise nuisance because of fridge-units on lorries. But the shop-keepers want their goods preferably delivered in one stop. New standards in multi-condition transports are requests. Our important innovation is, that we modify other industrial devices for multi-condition transport instead of modifying complete lorries. The Condi Supply Unit is an insulated container on wheels based for acceptable storage measures. It is a modular concept, completed with an environment friendly refrigerating system by the use of dry ice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'No stress with pArg: Mechanisms of a distinct phospho-mark to coordinate stress response and protein quality control'.

assistant: **Innovation**

Cellular proteins are prone to misfolding and aggregation, particularly under harsh environmental conditions. To counteract this danger, all organisms from bacteria to humans evolved sophisticated protein quality control networks. The mechanisms employed in them tend to represent some of the most exciting biochemistry occurring in living cells.In Gram-positive bacteria, the key factors combating protein damage include a specialized protein kinase phosphorylating arginine residues (McsB), the central housekeeping protease (ClpP), as well as a AAA chaperone targeting aggregated proteins (ClpC). We find this quality-control system, organized around a distinct protein phospho mark (phosphoarginine, pArg), a fascinating model to investigate novel principles of dealing with proteotoxic stress.Using an integrative approach, we will delineate the precise role of protein arginine phosphorylation in the bacterial stress response. We will first analyze how this unique modification influences the stability and function of targeted proteins in vitro and in vivo. We are particularly interested in the possibility of pArg serving as a bacterial, ubiquitin-like degradation signal. We will then address the mechanism and regulation of the protein arginine kinase McsB. This analysis will uncover the specificity of the pArg tagging system. Additionally, these studies will reveal enzymatic innovations connected with the pArg chemistry that, due to the dependence of bacterial virulence on McsB, are of pharmaceutical interest. To address the further processing of pArg-modified proteins, we will perform an in-depth structural characterization of ClpC and related AAA disaggregases. A better understanding of the mechanism and regulation of these HSP100 molecular machines is also highly relevant t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of multi-battery management system for renewable energies (MULTIBAT)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The objectives of the MULTIBAT project are to develop a multi lead-acid battery management system (hardware and software) in order to increase effectiveness and reliability of energy storage systems connected to renewable energy production plants (Photovoltaic systems, wind, biomass). The control of the charging (notably gassing phase) and discharging phases will allow increasing lead-acid batteries lifetime, easier maintenance operations and limitation of over sizing of the storage system. The reliability and effectiveness of the management system will be tested on different sites in Europe, comprising comparison experiments (classical and multi-battery systems in parallel) and tests in real conditions (domestic applications).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hadmar2001' to be submitted under Fifth Framework.

assistant: **Abstract**

The basic aim of HADMAR'2001 is to present, summarize and further develop the latest trends in hydrodynamics and aerodynamics attempting to cover as completely as possible all aspects of marine engineering - vehicles, environment, coast, in their complicated interaction. This will be done not only to allow researchers in similar or related scientific fields to exchange ideas and experience but also:- To introduce young researchers to the most up-to-date research methods and techniques in the field of fluid dynamics and to allow them to present their own developments and obtain an expert, evaluation by renowned scientists; - To introduce people from the industry to the capacity of hydrodynamic research and development and to promote their implementation in practice. While covering a wide application area, the Conference will highlight the following fields:- Hydrodynamic Loads and Responses: behaviour and safety of ships and ocean structures under severe environmental conditions; loads on coastal structure and their impact on coastal zone management; utilization of the energy of the Ocean. - Inland Navigation: efficient and environmentally-sound types of ships for the Trans-European waterway Rhine-Main-Danube; impact of navigation on river banks and structures; safety of inland navigation; transport efficiency and logistics of inland navigation; high-speed inland navigation.- Advanced Vehicles: catamarans, surface-effect-ships, air-cushion vehicles, novel hybrid concepts; stability and safety; wake-wash.- Information Technologies in Fluid Dynamics: advanced CFD-solvers; validation of computational results; CAD-CFD interface; modern technologies for data processing and transfer. The highlighted topics will be addressed by plenary sessions including keynote speeches and inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optical fibre sensor for the simultaneous detection of biliary" reflux and acidity in the foregut"' (1994-1998).

assistant: **Innovation**

The aim of this project is to develop a small, compact, portable, battery operated optical fibre sensor for the simultaneous detection of bile and pH in the stomach and in the esophagus. The development of such an optoelectronic unit will avoid hospitalization of the patient, with a consequent reduction of medical costs. The simultaneous detection of the above parameters will lead to a unique instrument capable of substituting the bile sensor and the pH monitoring unit. Multianalyte detection with the sarne device and optical fibre sensor technology will warrant the construction of an instrument essentially inexpensive in comparison with the sensors at the moment available on the market. Important issues that will be addressed in the project are: - detailed analysis of the physician requirements; - use of light emitting diodes at different wavelengths as sources and of SMD technique which can warrant the miniatunzation of the optoelectronic unit; - design and fabrication of the catheter and of the probe, which must be completely biocompatible, easy to construct and to be produced in large quantities; - in vitro characterization of the sensor: - in vitro validation on volunteers. ln the view of the project team the optoelectronic unit, characterized by different electronic channels connected with the same catheter, will have dimensions of 15x3x8 cm3, weight < 500 g and a market price of 6 KECU to be met resulting in a very competitive product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Validation of novel immunotherapeutic targets against fibrosis in inflammatory bowel diseases' in the context of a Horizon Europe call.

assistant: **Objectives**

Fibrostenosis is the driving reason for the persistent need in bowel resections in inflammatory bowel diseases (IBD). Current IBD therapies are limited to solely targeting inflammation. While these therapies in some, but not all, cases lead to symptomatic disease remission, recurrent flares interspaced with periods of remission will still result in cumulative gut wall remodeling and fibrosis. Indeed, despite these therapeutic strategies to control inflammation, fibrostenosis incidence and bowel surgical resection is not declining in IBD patients, as no anti-fibrotic drugs are currently available. The aim of this project is to validate fibroblast therapeutic targets for preventing and/or treating fibrosis in IBD-patient-samples with an emphasis on C3 and/or Tyk2/STAT3 and/or NLRP3 in the evolution of intestinal fibrosis. The anti-fibrotic efficacy and mode of action of these novel immunotherapies will be studied preclinically in IBD-patient derived samples and validated in animal models of chronic colitis. In parallel, we aim to develop and validate a clinical diagnostic and prognostic pathway for fibrosis in IBD patients based on the use of non-invasive cross-sectional imaging techniques such as magnetic resonance enterography with elastography and optoacoustic. These results together will allow to design a first-in-human proof of concept randomized trial of immunotherapeutic drugs targeting complement C3 and/or Tyk2/STAT3 and/or NLRP3 pathways in intestinal fibrostenosis. Our aim is to obtain patients and regulatory approval for implementation of these novel non-invasive imaging modalities as diagnostic and prognostic tools for fibrotic IBD to allow vital future therapeutic development for intestinal fibrosis. By providing better molecular and clinical stratification o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Technological improvement for ethanol production from lignocellulose' under Fifth Framework.

assistant: **Concept**

This project aims at development of cost effective and sustainable production methods for ethanol based on lignocellulosic waste materials or dedicated crops. The raw materials are among the potential ones in Southern, Eastern and Northern Europe, comprising forest and agricultural residues as well as a energy crop. The project focuses on the key issues, essential for improvement of the process steps in the conversion of lignocellulosics to ethanol. Novel technologies will be developed for pre-treatment and enzymatic hydrolysis steps, which comprise up to 50% of the present production costs. The aim is to increase the yield of ethanol, is well as to decrease the energy consumption in the production process. The production costs of ethanol would expectedly be reduced by 10-20% in medium-to-long term. A techno-economic analysis of the new process concept will be carried out.