RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Self-adapting applications for mobile users in ubiquitous Computing Environments' (MUSIC) targeting Sixth Framework.

assistant: **Abstract**

MUSIC is a focused initiative that will develop a comprehensive open-source software development framework that facilitates the development of self-adapting, reconfigurable software that seamlessly adapts to the highly dynamic user and execution context, and maintains a high level usefulness across context changes. Context-aware applications are capable of exploiting knowledge of external operating conditions, and they are self-adaptive if they adapt at runtime to varying contexts, like changing user needs and operating environments.MUSIC will provide a design methodology and distributed system architecture for the design and implementation of self-adapting applications in ubiquitous computing environments. This will be complemented with enhanced modelling languages for the specification of context dependencies and adaptation capabilities, supported by model specification, validation and simulation tools. This platform will be used to develop trial services, based on a set of challenging application scenarios with real market potential, having a central role: as sources of requirements, to assess technical adequacy of the results, and to promote the results.MUSIC thus invites the user to take for granted a high level of service usability, reliability and responsiveness. The user will be released from the complex configuration and administration that are imposed on users by many applications today. Thus, MUSIC is not only about the immediate technical objectives of self-configuration of context-aware applications, but it represents a noteworthy response to the vision of autonomic computing as articulated by major industrial players.MUSIC includes major industrial players in the mobile market, several SMEs (one IST prize winner) specialising in mobile services, organisati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanoscale live-cell activity sensing using smart probes and imaging' (NanoCellActivity).

assistant: **Innovation**

Fluorescence microscopy is the tool of choice for live-cell imaging. Its usefulness has been further enhanced by the availability of genetically-encoded biosensors, which enable the visualisation of when and where a certain activity arises. In addition, the development of diffraction-unlimited imaging has dramatically improved the spatial resolution of fluorescence imaging. However, these techniques have had difficulty working with biosensors, largely limiting the information to the spatial location of the labels. This project seeks to develop diffraction-unlimited imaging of biosensors, creating activity maps with a diffraction-unlimited spatial resolution in living systems. I propose to meet this challenge using a two-pronged approach, focusing both on the development of labels and sensors as well as new imaging tools and strategies. Based on existing scaffolds, we will develop sensors that display strong photochromism, providing reversible fluorescence dynamics intrinsically suited to superresolution imaging. In tandem, we will develop imaging strategies that focus on robustness and work well in living systems, in exchange for a spatial resolution of a 50 to 70 nm and a temporal resolution of a few seconds or less. We will use these developments in the study of the nanoscale spatiotemporal regulation of G-protein-coupled receptor (GCPR) signalling in living systems. By extending sub-diffraction imaging to the molecular environment, this project will contribute new insights into long-standing research questions that directly involve the health and well-being of all of us, while also enabling exciting prospects for further research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Thiocarboxylic Acid Derivatives: New Tools in Organofluorine Chemistry' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Within the tremendous development of organic chemistry, several specialized field have gained their own fame, both from their fundamental interest and their application. The organic chemistry of the heteroelements is symbolic of how can be artificial the c lassification of the sub-disciplines. Almost each heteroelement has its own international symposium, as if any heteroelement should be developed ignoring the others, such over specialization may restrict the creativity of the chemists whose mission is to e xplore any combination between the elements.Owing to the size of fluorine atom (the smallest element after hydrogen) and its electronegativity (the most electronegative element), its introduction into organic molecules induces considerable modification of their physico-chemical and biological properties. As a result, the family of organofluorine compounds play a crucial role in materials, pharmaceutical, agrochemical and more generally bioorganic chemistries. On the other hand, numerous very important organ ic reactions are the result of sulfur and/or silicon-mediated transformation of functional groups.The purpose of this project is to combine specific properties of sulfur and silicon derivatives to create new tools for the development of new reactions/produ cts in the field of organofluorine compounds.The key intermediates and reaction concepts of the project are:- thiocarboxylic acid derivatives- thiophilic nucleophilic attack- the high fluorophilicity of silicon- nucleophilic trifluoromethylation- electroph ilic trifluoromethylation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A tactile prosthesis to improve speech perception in persons with hearing loss.' in the context of a Horizon 2020 call.

assistant: **Objectives**

The “FeelSpeech” project will provide proof of concept of a novel prosthesis that will allow people with hearing loss to better understand speech. The prosthesis will be worn on the wrist and will resemble a wristwatch. A special, novel kind of tactile stimulation called “microstroking” provided by the device will supplement what a person hears, and this information will be unconsciously made use of by the user’s brain, providing improved speech perception even when the user has almost lost all hearing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Formal specification and verification of distributed multimedia systems'.

assistant: **Concept**

Research objectives and content Most of the major developments in distributed multimedia computing have focused on constructing prototypical applications, such as, multimedia conferencing, video on demand, multimedia mail, video phones and teleworking. As is typical of rapidly expanding new fields of research, an applied (engi- neering) approach has been almost universally adopted. The emphasis has been placed on building systems, rather than formally defining the precise behaviour of developed systems. However, a formal approach can benefit multimedia by aiding the development of correct (error free) systems. In response, we propose research directly targeted at the forma specification and verification of distributed multimedia systems. This research will unite the complementary skills of the proposer and host institution. The proposer has significant experience in multimedia computing and specification of such systems, while researchers at VERIMAG have developed some of the best verification tools now available. The research will have two main threads. Firstly, the applicability of a spectrum of specification notations to the multimedia application area will be assessed. Secondly, the verification techniques available at VERIMAG will be specialized to the application domain. In particular, the KRONOS symbolic model checking tool will be applied to the verification of multimedia systems. Both these tasks contain significant technical hurdles and will make a major contribution to the development of multimedia applications that satisfy given requirements at reasonable costs. Training content (objective, benefit and expected impact) The fellowship will enable the proposer to aquire expertise in the development and use of advanced real-time verification tools and technique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Systems Biology of Gulcose Repression in Yeast' (SYBGRY).

assistant: **Concept**

Biology is moving from describing phenomena to understanding the design principles and dynamic operation of cellular modules, entire cells, and even organisms. This new approach, which has been termed systems biology, aims to holistically understand biological processes by employing mathematical analysis and computational tools to integrate the information content obtained in experimental biology and engineering.In this project, experimental and theoretical studies will be integrated to achieve a better understanding of the dynamic operation of glucose repression signalling pathways in yeast for design of glucose de-repressed strains. Such strains are industrially attractive as cell factories for improving baker's yeast production from molasses, bioethanol production for sugar mixtures, and heterologous protein therapeutic production. Moreover, since glucose repression in yeast serves as a model for nutrient sensing in eukaryotic cells, the development of algorithms for this system may be applied to mapping of signa transduction pathways in higher eukaryotes - including humans.This will ultimately facilitate drug discovery and drug target identification for complex diseases. To achieve this goal, genome-scale models will be combined with DNA array and metabolite profiling data of several glucose repression mutants. Detailed characterization of these mutants by model guided analysis of global cellular function will allow mapping of all pleotrophic effects, identification of co-regulated metabolic patterns, and subsequent engineering of the desired strains. This study will have a broad impact on the field of systems biology and yeast physiology/genetics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Photonic mm-Wave Functions For Broadband Connectivity' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

IPHOBAC will develop a new photonic based mature transmitter and receiver technology to support millimeter-wave applications.<br/>IPHOBAC aims at developing innovative millimeter-wave photonic components and integrated functions generically based upon the combination of radio and optics technologies. IPHOBAC has a set of innovative approaches for the development of millimeter-wave photonic components and integrated functions for the generation, the modulation and the emission of millimeter-wave signals. IPHOBAC ambitious objectives will bring millimeter-wave photonics components and integrated functions to a level of maturity such that take-up actions by industry will be ensured. The new integrated functions enabled by IPHOBAC will support multiple mm-wave applications in broadband telecommunications, security, radar, and instrumentation.<br/>Advanced and compact photonic sources will be developed, including spectrally pure, highly stable millimeter wave sources and ultra-wide tuneable sources and transceivers with integrated antennas. These compact sources can neither be implemented by any extension of individual optics nor individual radio technologies. They will be used in Gbit/s radio-over-fiber systems, optically controlled antennas and instrumentation applications.<br/>IPHOBAC integrates a chain of partners, from academic research to industrials, from technology centers over component manufacturers to end-users, all known for their previous achievements in microwave photonic components and technologies. The joint efforts will bring millimeter-wave photonic components for generation and detection of high purity millimeter waves to a level of maturity enabling commercial exploitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Persistent and Transportable Hyperpolarization for Magnetic Resonance'.

assistant: **Concept**

Magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) and are two well-established powerful and versatile tools that are extensively used in many fields of research, in clinics and in industry.Despite considerable efforts involving highly sophisticated instrumentation, these techniques suffer from low sensitivity, which keeps many of today’s most interesting problems in modern analytical sciences below the limits of MR detection. Hyperpolarization (HP) in principle provides a solution to this limitation. We have recently pioneered breakthrough approaches using dissolution dynamic nuclear polarization (d-DNP) for preparing nuclear spins in highly aligned states, and therefore boosting sensitivity in several proof-of-concept reports on model systems. The proposed project aims to leverage these new advances through a series of new concepts i) to generate the highest possible hyperpolarization that can be transported in a persistent state, and ii) to demonstrate their use in magnetic resonance experiments with > 10’000 fold sensitivity enhancements, with the potential of revolutionizing the fields of MRI and NMR.By physically separating the source of polarization from the substrate at a microscopic level, we will achieve polarized samples with lifetimes of days that can be stored and transported over long distances to MRI centers, hospitals and NMR laboratories. Notable applications in the fields of drug discovery, metabolomics and real-time metabolic imaging in living animals will be demonstrated.These goals require a leap forward with respect to today’s protocols, and we propose to achieve this through a combination of innovative sample formulations, new NMR methodology and advanced instrumentation.This project will yield to a broadly applicable method rev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Low Cost Materials Processing Technologies for Mass Production of Lightweight Vehicles' (LoCoMaTech) targeting Horizon 2020.

assistant: **Abstract**

The overall aim of LoCoMaTech is, in the first place, to enable the novel HFQ® process, (patented by ICL) in its latest most advanced form, which includes 10 recently patented refining technologies (TRL4), to be used for the manufacture of lightweight, high strength body and chassis structures and components for low-cost vehicles, by establishing a prototype, full scale pilot production line (TRL6), supported by a supply chain ranging from raw material to end of life. This will be the first low-cost technology in the world enabling manufacture of high-strength lightweight complex-shaped aluminium parts and low environmental impact. The 1st generation of HFQ technology has already been commercially used in manufacturing 4 types of niche vehicles. This project aims at bringing the materials and manufacturing cost significantly down, through introducing newly patented technological measures, by which the technology could be used for producing low-cost vehicles. The low-cost HFQ® technology will be used first for mass production of aluminium car body and chassis structures (eventually for all vehicles), which will lead to substantial improvement in energy efficiency, performance and travel range of low-end vehicles. LoCoMaTech will construct a world first low-cost HFQ® aluminium production line (prototype), targeting reduction of energy consumption per vehicle by 15.3-22%, and cost-effective weight savings from 8.55 to 2.16 €/kg-saved and improvement of LCA environmental impact by 15.39-26.8%. LoCoMaTech plans to assist in creating 53 commercial production lines and 1700 jobs, in year 6 from the completion of the project. The potential market for low-cost HFQ® technology for passenger cars alone is over €160 billion pa, and double this, if buses, trucks, trains and aircraft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Second funding line in Work Programme 2018-2020 for the further development of a European SST Service provision function'.

assistant: **Objectives**

The goal of the 2-3SST2018-20 project is to enhance and evolve the EUSST system in line with the Decision nº 541/2014/EU. Three main objectives have been set for the scope and duration of the activity:1. Foster European Cooperation in the SST domain: at this respect, the Joint Project Management Team, started in the 1SST2018-20, will be continued and further evolved; special focus will be devoted to Risk Management and  KPIs for improving the performance monitoring. A closer supervision of the fulfillment of the schedule and financial commitments, with improved quarterly flash reports, will be carried out. Additionally, technical evolutions will raise cooperation among participants, for example by means of the development of a SW prototype for a coordinated scheduler of sensors and the analysis for the evolution of the EUSST catalogue precursor.2. Improve the EUSST performance towards larger autonomy: the developments needed for the evolution of the sensor, service and processing functions will be defined for its further deployment into the operational layer. Alignment of the activities under 1SST2018-20 and 2-3SST2018-20 will be ensured by the EUSST Governance, in line with the architecture studies and the users’ needs. Special efforts will be done in the domain of the EUSST Database, the EUSST catalogue precursor, architecture studies and the interaction with stakeholders and users.3. Pave the way for the evolution of the European SST to respond to new challenges in Space: last, but not least, sensors with high added value to the EUSST system, as identified in the Architecture trade-off will be upgraded. Moreover, studies with sounded technical content will be carried out in all the domains (sensors, data processing and services) to ensure the EUSST is prepared for th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dynamic Mapping of Mitochondrial Translation Initiation and Elongation'.

assistant: **Concept**

The DYNAMITE project aims to uncover the precise sequence of molecular events that govern human mitochondrial translation initiation and its transition to elongation. Mitochondria are essential for energy production, and defects in their translation machinery cause severe diseases and contribute to drug toxicity. Despite recent structural advances, the dynamic steps of initiation remain poorly understood.To address this gap, DYNAMITE will combine kinetic assays using stopped-flow fluorescence to quantify the timing and order of initiation events with time-resolved cryo-electron microscopy to capture structural snapshots of transient intermediates during initiation and early elongation. These datasets will be integrated into a unified, time-stamped mechanistic model, linking reaction rates with structural transitions.This work will deliver the first dynamic framework of human mitochondrial translation, providing fundamental insight into how the mitoribosome functions at its earliest stages. By revealing regulatory checkpoints and structural transitions, DYNAMITE will open new avenues for studying disease-associated mutations and designing safer, mitochondria-sparing drugs. Ultimately, this knowledge could help reduce the risk of mitochondrial toxicity, which is a major cause of late-stage drug failure, and accelerate the development of effective therapies for mitochondrial disorders and other conditions linked to mitochondrial dysfunction.


**Keywords:** human mitochondrial ribosome, enzyme kinetics, time-resolved cryo-EM