RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ProTon Europe' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the project is:- to facilitate Networking among public research Organisations' transfer offices, for the exchange of experience and good practice at European level;- to contribute to raising general professional standards;- to provide an extensive geographical scope to networking activities, including regions and operators that may usefully benefit from the interaction (in particular regions of the EU and Associated States where this activity is hitherto less developed);- to provide Commission services with access to these operators, in order to extract innovation policy lessons at European level.The work plan will be carried out through 14 different work packages. The first 3 work packages concern the co-ordination of the project and the management of the network, the development and the running of the network and the organisation of activities and events which disseminate the outputs of the network and raise its visibility to its target group - TOs throughout the EU and the NACs. The management of the network is shared by the principal contractors in liaison with the co-ordinator.The following 6 work packages (4 to 9) focus on the development of content through thematic working groups clustered around the following 6 themes: TO structure and management, patenting/IPR, licensing, interaction with industry, spin-offs and campus companies and policy development. Underpinning these thematic or vertical working groups are 4 generic or horizontal work packages (10-13), which provide input to the thematic vertical working groups and which help to shape coherent and diffusible outputs produced by the working groups for use by the network members/adherents. These 4 work packages are structured along the themes of continuous professional development and training, goo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of biomolecular tools for the spatiotemporal photocontrol of AMPA receptors mobility' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The PhotoXLink project aims to develop original tools to elucidate the role of various AMPA receptor mediated forms of plasticity in both physiological and pathological situations. AMPAR is a transmembrane ionotropic receptor for glutamate molecule that mediates most fast excitatory synaptic transmission in the mammalian central nervous system. Its regulation is vital for their synaptic function, which underlies memory and learning theories. In the PhotoXLink project, we propose to engineer novel optogenetic tools (photocrosslinkers) that will specifically recognize AMPAR subunits and control their oligomeric state with spatial and temporal resolution. The photocrosslinkers will hence provide a unique control locally, acutely and in a reversible manner on the mobility and local number of AMPARs. The development of these photocrosslinkers will address current technical limitations and ultimately allow investigating with an unprecedented spatiotemporal resolution the impact of AMPARs mobility in short and long term plasticity in the brain function. The multidisciplinary nature of the project is strong, involving molecular/cell biology, biochemistry and protein engineering for the design and production of the tools and advanced fluorescence imaging techniques for validating them in cellular context. It will be carried out at an internationally recognized neuroscience institute that will enhance my skills and diversify my individual competences through advanced training and quality research for improving my future career development. My expertise in photochemistry and photobiology combined with the host´s in neurobiology and protein engineering ensures the best chance for successfully fulfil the goals of the PhotoXLink project. This project is in line with the brain researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mathematical Logic and Applications' (MATHLOGAPS) targeting Sixth Framework.

assistant: **Abstract**

The proposal is for multi-participant Early Stage Research Training in Logic and Applications by three partners: the Universities of Leeds and Manchester; University Claude Bernard Lyon l and the Cole Normal Superior Lyon; and Ludwig Maximising Universitat Munched. Each partner has a large group producing high quality research in several branches of Logic, and together the partners cover most of the active fields of Logic and its links to Theoretical Computer Science, AI, and IT. There are already close collaborative links between the partners. Each partner has a large and successful Logic PhD programme. The grant will offer each partner several very strong extra PhD students and short-term student visitors. Students mostly will stay with more than one partner, and so broaden their logical background and range of influences. The scheme will fund 4 training workshops for students. Logic is a dynamic subject. In one direction, Model Theory has increasingly sophisticated applications to other parts of mathematics, and in another, Proof Theory, Complexity Theory, and the study of Reasoning under Uncertainty are applied to Computer Science, AI, and IT. Despite specialisation and the wide spread of the subject. Logic has a unity, witnessed by many new links across the subject, such as between Complexity Theory and Model Theory. The partners aim that the Early Stage Researchers will appreciate and exploit this unity. The partners will provide several aspects of structured training: technical training in a student's field; the development of a broad knowledge of Logic; and the acquisition of the complementary skills relevant to a research career. The scheme will equip Europe with a much-needed group of highly trained scientists in a flourishing field of wide impact, whilst stre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development trajectories of temperate forest plant communities under global change: combining hindsight and forecasting (PASTFORWARD)' under Seventh Framework.

assistant: **Concept**

The last decades are characterized by an upsurge of research on the impacts of global environmental changes on forests. Climate warming, atmospheric deposition of acidifying and eutrophying pollutants and land-use change are three of the most important threats to biodiversity in temperate forests. However, most studies focused on the effects of single factors over short time periods, such that our ability to predict the combined effects of multiple global change drivers over longer time periods remains rudimentary. The lack of knowledge on effects of global change drivers on forest herb layer communities is particularly striking, since the herb layer contains the largest part of vascular plant diversity in temperate forests and provides key ecosystem services. Therefore PASTFORWARD will build an integrative understanding of the interactive effects of land-use change, atmospheric deposition and climate warming on forest herb layer communities, starting from the insight that changes in herb layer communities are driven primarily by past land use, but can be modulated by atmospheric deposition, climate warming and forest management. Indeed, it is still largely ignored that sensible predictions of herb layer development trajectories under global change can only be made by taking the forest’s land-use history into account, as legacies of past land use can leave century-long imprints on forest herb layer communities. Three complementary data sources (a database with resurveyed vegetation plots, field measurements in a pan-European network of resurvey plots, and a multi-factor experiment) combined with an ecosystem model will be used. Furthermore, concepts and tools from different disciplines, ranging from history over sylviculture to community and ecosystem ecology will be ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AEGEUS - A Novel EEG Ultrasound Device for Functional Brain Imaging and Neurostimulation' to be submitted under Horizon Europe.

assistant: **Abstract**

The overall goal of this project is to develop a radically new diagnostic and therapeutic device for neurological applications which combines a highly innovative ultrasound component for brain imaging and focused stimulation of brain regions with advanced electrophysiological measurements of neural activity.First goal of the project is the development of a novel ultrasound (US)-based functional imaging method that, in conjunction with electroencephalography (EEG), allows for high spatiotemporal resolution examination of brain activity. While EEG itself yields best data from neural tissue close to the skull, the US component is designed to deliver images from deeper brain regions.The second pillar of the devices function is focused US brain stimulation. Based on the possibility to localize abnormal activity, the neuromodulation component of the novel device can be guided to focal stimulation of selected brain regions, which can be further developed into a closed-loop design. The full envisioned system is a versatile tool that combines EEG-sensors and US transceivers in a wearable headset. The project foresees the development of hard- and software as well as algorithms to integrate the information from both modalities into functional neuroimaging with unpreceded spatiotemporal resolution.Beyond the technical realization, this project includes a proof of concept study to evaluate and demonstrate practical applicability in healthy participants and in patients with epilepsy, during clinical routine examination, cognitive, and sensory stimulation, including test-retest validation. The new device will reduce the time to examine and treat neurological patients and the cost thereof. The ability to perform better diagnosis via accurate imaging, targeted neurostimulation, and neur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of greenhousefoils and additives to optimize the plant growth through control of photomorphogenese.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Control of plant growth & diseases is a major problem in horticulture which todays solved by quantities of chemical growth regulators, fungicides and herbicides. Cost, increased ecological awareness and regulatory issues call for substitutes. One promising solution is through selective filtering of the sunlight. Researchers in D, IL, J, and NL, UK have demonstrated the principle, but no solutions are commercially available as yet. The SME partners from Germany and Israel therefore aim at developing with the help of leading research partners in the field, designer plastic cladding foils for greenhouses with integrated spectral filters. Material properties will be defined for optimum use in horticulture in different climates: PAR transmission > 90 %; NIR transmission < 30%; very low FIR transmission; photo selectivity according to climatic needs: low transmission of dark-red / extended dark-red, selective UV transmission; good mechanical and chemical properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Antibiotic intracellular delivery via virus-like carriers' (AIDViC).

assistant: **Innovation**

Taking inspiration from natural carriers, such as viruses, a new technology has been developed inour laboratories part of an ongoing ERC starting grant project, Molecular Engineering of Virus-likeCarriers (MEViC). We created synthetic viruses using polymers and thus safer materials. They areable of delivering high payload of specific drugs into cells with no detrimental effect. While testing foranticancer therapies, we identified a synthetic virus capable of targeting almost exclusivelymacrophages. We performed preliminary work showing that this can be successfully applied todeliver antibiotics to rid of intracellular pathogens. This has now open a completely new possibilitywhereas we can expand our technology for the treatment of several infections as well as to contributeto the ongoing efforts in tackling antibiotic resistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Vacuolar Transport equipment for growth regulation in plants'.

assistant: **Innovation**

Plant growth is a fundamental biological process that impacts food production and landscape structuring, and is highly relevant for the goal of an integrated and sustainable agriculture in the EU. Growth is a highly co-ordinated process involving multiple scales, ranging from molecular entities through cellular structures to the whole-tissue and organ level. Environmental cues also strongly affect growth of higher plants.The plant vacuole can be considered as a central cellular integrator of growth signals. It links growth to the maintenance of the plant's structure (turgor control) and has a pivotal role in cellular detoxification and as a storage organelle. The linkage of vacuolar transport activities to plant growth processes is poorly understood. The VaT EP research training network specifically targets transport proteins located in the vacuolar membrane (i.e. tonoplast) to unravel their specific functions with respect to plant growth processes in the following main objectives:(1) identification of new ton oplast proteins in different species and extensive molecular and biochemical characterisation;(2) investigation of the dynamics of tonoplast transport equipment in response to growth stimuli;(3) analysis and modelling of the dynamics of leaf and root growt h controlled by tonoplast proteins.The VaTEP RTN offers a structured 3- year training for European PhD students. PhD students will be trained in a biological discipline that covers multiple levels and links molecular events to whole-tissue growth in plants. It offers measures to develop skills and competencies in various technological and innovative aspects. Young researchers will additionally be trained in a number of complementary skills, including project management and financing, IP rights, ethical issue s,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neutral organic receptors for halide anions' (1994-1998).

assistant: **Innovation**

Research objectives and content Although there are many neutral organic receptors for cations (cationophores), there are very few analogues for inorganic anions. The group of Prof. Davis has recently synthesized such a compound, with unprecedented potency and selectivity as a receptor for halide anions (especially chloride). I propose to develop an improved synthesis of this anionophore and/or develop a synthesis of an alternative which may prove even more effective. With either system as a starting point, I will investigate the possibility of tuning" potency and selectivity through adjustment of the functionality present. I will also study the ability of these receptors to extract anions into organic media and mediate transport through bulk organic membranes. Anion transport through liposomal membranes, through natural cell membranes and at electrode surfaces will be investigated in collaborations with other groups. Training content (objective, benefit and expected impact) My "tesina" research in Spain has introduced me to the study of molecular (especially anion) recognition. This project will extend my training in relevant areas of synthetic chemistry, and also in theoretical and "physical organic" aspects of supramolecular chemistry. Exposure, through collaboration, to analytical, physical chemistry and biochemistry groups will broaden my experience further. Links with industry / industrial relevance (22) The work may lead to improved analytical methods for anions, and may also yield compounds with useful biological activity. The Dublin group has an industrial collaboration in the former area, and several companies have expressed interest in the latter. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterization of engine exhaust particulate fingerprints and their contribution to air quality' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Air pollution generated by fine particulates is suspected of non negligible health related effects. The development of efficient control strategies for air pollution requires to know the relative importance of the various sources which contribute to airborne particulate matter. Among these sources, motor vehicle exhaust is considered as an important contributor to urban aerosol. Chemical mass balance (CMB) models can be used to estimate source contributions, to urban aerosol by comparing the chemical compositions of source emissions profiles with that of ambient air. Nevertheless the application of such models relies on the ability to get chemical compositions specific of each source and which are sufficiently different from one source to another. The main objectives of this study are : 1. to determine the chemical composition of particulates emitted by various types of engines (heavy duty and light duty, diesel and gasoline). 2. to select tracers or fingerprints specific of each engine. 3. to evaluate the feasability of using much fingerprints to identify the contribution of each engine category to ambient particulates through chemical mass balance (CMB) modelling. The research will be organised in three main phases : Phase 1 The work will consist in the selection of the appropriate analytical techniques for the determination of reliable fingerprints for particulates emitted by various engines, including LD and HD diesel engines and LD gasoline engines. Attention will be paid to the harmonization of the operating protocols between the partners involved in this task. Sampling and collection of particulates will be optimized especially in the case of low emitting gasoline engines.  Partners 2, 3, 5 and 6 will participate to this phase. Phase 2 The same analytical determi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Diagnostic of chronic kidney disease and renal transplant pathologies through the direct and kidney-wide mapping of microvascular anomalies with sensing-volumetric Ultrasound Localization Microscopy' to be submitted under Horizon Europe.

assistant: **Abstract**

Chronic kidney disease (CKD) is a major global health issue, with peripheral kidney microvascular damage being a hallmark feature that is challenging to assess and often requires renal transplant. Current diagnostic methods for monitoring microvascular complications in renal grafts, such as biopsies, lack the practicality needed for regular assessment.Ultrasound localization microscopy (ULM) and sensing-ULM (sULM) present a promising approach, providing detailed metrics on the microvascular network. We have demonstrated that sULM can visualize glomeruli in a patient's kidney in 2D by observing the peculiar swirling behavior of clinically common microbubbles within them. Such a technique could be used to characterize the kidney's microcirculation and its modifications by pathologies like CKD, but was severely impaired by its planar character.A sensing-volumetric-ULM, 3D, technique could transform renal transplant management by offering a non-invasive, portable solution to monitor vascular health and detect early graft dysfunction in entire kidneys at the microscale. This innovation builds on the ERC Cog ResolveStroke and ERC POC StrokeMonitor projects. The KidneyScope project, combining volumetric ULM and this glomerular insight, represents a promising approach to address the urgent need for high-resolution renal microcirculation assessment.