RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Commercial & Research Opportunity for Cysteinyl Leukotriene Signalling in Ocular & CNS Dysfunction, Cancer and Cardiovascular Disease' under Horizon 2020.

assistant: **Concept**

Cysteinyl leukotrienes (CysLTs) are potent lipid mediators of inflammation. CysLT1 and 2 receptors are widely expressed e.g. lungs, colorectum, heart, brain & eye; and CysLT1 antagonists are prescribed to treat airway inflammation. Excitingly, CysLT signalling was recently discovered to regulate the biology of vascular, neuronal and cancer cells underpinning its untapped therapeutic potential in other diseases. CRYSTAL3 interconnects unique and diverse researchers to create a multidisciplinary team sharing expertise and research capacities. The contribution of CysLT signalling to disease is divulged; its therapeutic potential unlocked and new services & products commercialised. This is delivered by staff exchanges to jointly research Ocular & Central Nervous System (CNS), Cardiovascular system (CV) and Cancer diseases.The R&I goal of CRYSTAL3 is to reduce human disease burden by enhancing EU capability and knowledge-sharing in research and commercialisation. This is achieved through advanced international co-operation between 5 academic and 5 non-academic partners, in 7 countries. The focus is on innovative research into the CysLT signalling pathway in human diseases related to the Ocular-CNS, & CV systems and Cancer (OCCC).The 3 overall objectives of CRYSTAL3 are:A) Combine resources to discover novel pathological mechanisms linking cysteinyl leukotriene signalling to ocular, central nervous system, cardiovascular disease and cancer (OCCC).B) Unite partner capacities to uncover the therapeutic potential of cysteinyl leukotriene signalling in ocular, central nervous system, cardiovascular disease and cancer (OCCC).C) Commercialise products and services co-developed within CRYSTAL3The CRYSTAL3 consortium tackles these challenges by promoting cross-sector, inter-European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Mercenaries in the Dutch Empire. A Connected History of Continental Europe and Colonial Indonesia, c. 1800—1900' (EuMeDE).

assistant: **Concept**

Being one of the smallest 19th century European powers, however with one of the largest overseas empires, the Netherlands continuously depended on non-European services, resources and man-power to build and run their far-flung island empire in Southeast Asia. Unsurprisingly, around 40% of the European soldiers employed by the Dutch Colonial Army between 1816 and c. 1914 were non-Dutch, hailing mostly from Belgium, Germany, France, and Switzerland. How did the Dutch manage to recruit ca. 70.000 European foreigners into their colonial army? And how did these men not only help build the Dutch Empire, but through their imperial careers also affect the histories of those European regions they came from? Using a database with biographic information on all 175.000 European soldiers and mercenaries in the Dutch Colonial Army, this project will be the first to tell the 'forgotten' story of deep historical connections between Indonesia, which today is the largest Muslim-majority and the overall third largest democracy in the World, and vast parts of Western- and Central Europe. Uncovering this largely unknown connected history will impact European Global History, Dutch Colonial History and the national histories of the mentioned countries. Carrying out this project under the supervision of Prof. Roland Wenzlhuemer at the Munich Centre for Global History will deepen my conceptual understanding of Global History, widen my methodological skill set, and improve my leadership skills. This will significantly increase my chances of getting a tenured position for European and Global History.


**Keywords:** Dutch Colonial History, Southeast Asia, Indonesia, Netherlands, Germany, France, Switzerland, Belgium
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fast Radio-Labeling and Isotope Exchange' (FASTLabEx).

assistant: **Innovation**

The impact of synthetic organic molecules on health, life quality and lifestyle is beyond doubt. It is therefore of fundamental importance to detect and quantify the fate of organic compounds and provide a precise risk/benefit assessment, before they reach the market and large public exposure. The traceless incorporation of carbon-14 allows tracking organic molecules and provides vital knowledge on their fate. This information is critical for pharmaceutical development, crop science and human food safety evaluation. Surprisingly, carbon radiolabeling still represents a bottleneck and an unsolved fundamental problem. In fact, current synthetic strategies are marred by several major drawbacks, including the generation of radioactive waste, being multi-step time-consuming and high resource-demanding. To circumvent such disadvantages, I present FASTLabEx, a novel approach for the straightforward preparation of carbon-labeled complex organic molecules that introduces the radioactive tag at the ultimate-stage of the synthesis. Inspired by efficient metal-catalyzed transformations, FASTLabEx makes use of a novel paradigm of carbon isotope exchange, defined as the selective replacement of molecular moieties into organic molecules, by reversible molecular deconstruction/reconstruction in presence of an appropriate radiolabeled moiety. FASTLabEx will explore this concept onto a large variety of functional groups and structural diversity, far beyond the case of carboxylic acids. This approach has the potential to streamline the radio-synthesis of pharmaceuticals and agrochemicals. Outcomes from FASTLabEx will have a tangible societal impact not only for the radiochemical community, but also for pharmaceutical and agrochemical industries and in fine the consumers and patients. In o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Best-in-class canceR dIaGnostic cHip for patient sTratification.' (BRIGHT), addressing dissemination and exploitation.

assistant: **Impact**

Through advanced microengineering and nanotechnology, we have developed a proprietary microfluidic-based liquid biopsy device, the RUBYchip™ (PCT/EP2016/078406). This technology allows for the isolation of all types of CTCs, keeping them viable and enabling the analysis of their phenotypic, genetic and functional characteristics, enabling unprecedented frequent monitoring of cancer progression in a minimally invasive and cost-efficient way. Our chip isolates 70% of the very scarce CTCs from a 7.5mL blood sample of a cancer patient in less than 3 h and without the need of sample pre‐processing. This dramatic improvement in the sensitivity compared to competition is enabled by a unique microfilter network embedded in a microfluidic device that separates the CTCs from the healthy cells based on their size and deformability. Furthermore, the RUBYchip enables automation reducing inter-laboratory and inter-user dependence and ensuring reproducible analysis of CTCs.


**Keywords:** Personalised medicine,Microfluids,Liquid biopsy,Circulating tumour cells,non-invasive monitoring,companion diagnostics,metastasis,cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bertha G - better enzymes - than gas' (BERTHA-G), addressing dissemination and exploitation.

assistant: **Impact**

BERTHA-G stands for “Better enzymes than gas”. Our first-of-its-class system enables independence from centralized supply of fossil fuel (i.e. natural gas, oil) for residential heating purposes (15’000 kWh therm. p.a).Applied at a national level, our approach can help disrupt the conventional energy supply and shift the demand from limited oil / natural gas from external suppliers to synthetic fuels which are cost-efficient and non-volatile (price), not limited by nature and CO2 neutral.This will be achieved by a cutting-edge proprietary technology: using the platform technology of Gensoric GmbH, an electro-biocatalytical process converts plain water, CO2 from ambient air and electricity into preferably Methanol. In contrast to alternative CO2-to-fuel-technologies, this process runs under mild conditions: no high pressure, no high temperatures. Owing to the selectivity of the enzymatic process, CO2 can be taken from ambient air, there is no need for a refined or concentrated volume streams. All steps can be carried out at ambient conditions which makes it suitable for residential applications. All educts needed are available, even the electrolytic production of hydrogen can be waived, as the enzymes take the needed hydrogen directly from plain water. The electrical energy can be taken from installed renewable energies, an effect which can make installed system more economically viable, especially for storing purposes, which will dramatically increase the efficiency. To facilitate the usage, our system is compatible to already existing infrastructure. Through our solution, we empower the customer to become a “prosumer” or producer and consumer of energy to mitigate the volatility of energy prices, to become energy independent, and contribute to a CO2 neutral economy. In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Association between influenza virus RNA polymerase and the transcriptional machinery of the host cell'.

assistant: **Objectives**

Influenza infections represent a worldwide problem both in terms of public health and economic consequences. Seasonal influenza epidemics affect 3 to 5 million people annually and are estimated to cause 250,000-500,000 deaths globally. Besides, recurrent pandemics are a serious threat because novel viruses can emerge to which the population has no pre-existing immunity. In the event of such a situation, existing vaccines would be unlikely to be effective and production of a vaccine matching the pandemic virus would require several months. In addition, existing antiviral treatments are very limited and development of resistance by the virus would reduce their effectiveness.  Thus, there is clearly an urgent need to develop new treatments for the control of influenza.The viral RNA polymerase is at the core of the transcription and replication complex of influenza virus and it is a crucial factor for pathogenicity and host restriction. Its activity is regulated by interactions with the host cell. Previous research in the host group has shown that the viral polymerase interacts with cellular RNA polymerase II (Pol II), but many aspects of this interaction remain unclear and its biological role is not known. This project will explore this interaction under the hypothesis that it is required for synthesis of viral mRNA. We will map the Pol II-binding domain of the viral polymerase. If the interaction is not direct we will identify the mediating factor(s) using proteomic approaches. The functional significance of the association between viral polymerase and Poll II will be investigated in vivo using a combination of reverse genetics and ChIP-sequencing approaches. This project is expected to identify novel druggable targets where essential interactions between the viral machin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'ENHANCED OIL RECOVERY THROUGH EFFICIENT PERMANENT INSTRUMENTATION FOR RESERVOIR CHARACTERISATION AND MONITORING'.

assistant: **Innovation**

The aim of the Project is to demonstrate that reservoir monitoring can be done efficiently and reliably over any size oil field and over the whole life of the field. Such a system will allow oil companies to improve reservoir control, to enhance recovery and to reduce production cost and risk.The three main objectives of the project are:1. To reduce the cost of the system, thereby making it attractive to install in all reservoirs where it is possible to monitor the fluid movement.2. To demonstrate that this technology works at water depths down to 1.500 meters.3. To demonstrate reliability fully adequate for operation during 10 years.This demonstration will help implementing reservoir monitoring by making it technically and economically feasible to install in a large number of both new and old oil fields.European increase in recoverable hydrocarbon reserves is estimated to 528 million TOE over 20 years.The Project aims to demonstrate Reservoir Monitoring as a feasible tool for enhanced oil recovery from producing reservoirs. The innovative parts in this Project are several:* Permanently installed seismic receivers at the seabed ensures repeatable data acquisition over the lifetime of the reservoir. This repeatability is crucial to obtain subsurface images clear enough to detect unswept pools of hydrocarbons on the reservoirs.* Permanently installed seismic receivers can receive data from all angles and distances and will handle subsurface differences associated with azimuth and offset better than conventional towed marine streamers.* Electronics and receivers are to a large extent integrated within the cable system. This integration provides for protection and hence reliability as well as reduction of number of connectors. Subsea connectors are one of the main problem a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Public acceptance of hydrogen transport technologies (ACCEPTH2)' (ACCEPTH2) targeting Fifth Framework.

assistant: **Abstract**

The introduction of hydrogen fuelled vehicles is taking place in selected demonstration cities worldwide, with a view to achieving full commercialisation. However, the successful introduction of these vehicles will depend not only on technical maturity, but especially on public acceptance of these new fuels and technologies. The work detailed under this proposal will contribute strongly to a better understanding of the acceptance of hydrogen technologies, and hence enable the introduction of hydrogen buses to be carried out with a clear strategy towards public acceptance. The work compares public attitudes in London, Luxemburg, Munich, Perth and Oakland, enabling international comparisons of perception to be made and contributing to the international R,D&D co-operation objectives of the Ec. The work is complementary to many existing EC, national and industry projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imgc2001' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The International Mouse Genome Conference (IMGC) meets annually to discuss and report on progress in mouse genetics, and genomics. The recently reported draft sequence of the human genome means that the focus in genomics moves from identifying gene content to gene function. The mouse is the principal model mammalian organism: it has essentially the same gene content as human, but these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An accounting integrated carbon management tool for supply chain decarbonisation of SMEs.' (Insight) under Horizon 2020.

assistant: **Objectives**

"The market for carbon accounting is a niche but rapidly growing market with the EU market alone being worth £2 billion. Currently all carbon accounting solutions for companies are a time-consuming and expensive process carried out manually by specialised carbon accounting firms. Insight is robust, dynamic carbon and water footprint calculation tool for use by SMEs and suppliers (e.g. manufacturers, energy providers, material suppliers). The platform has proven interoperability with widely-adopted accounting software packages and the underlying data it maintains. The proposed integration would derive the carbon footprint of the company by analyzing its accounting records with the Insight platform simply by the user entering his or her account details, authorizing the integration - after this, the user would receive a full, visual analysis of their carbon footprint, and recommendations for how to reduce it. The system is fully automated with analyses being carried out in 1-2 minutes and is free to use by SMEs. Insight is also a platform for manufacturers, energy providers, and  resource suppliers to advertise their services to SMEs looking to reduce their environmental impact in the supply chain. The feasibility study will help  determine the potential for Insight to become fully automated. This automation is critical for delivering on the unique value proposition we present to EU SME's, namely that the platform must require minimal time and financial commitment by the SME user. The project will focus on establishing a sound business model and commercialization strategy as well as planning the necessary activities to deploy a pilot test involving SMEs and suppliers.""""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterisation of ltrpc2 physiology and its role during metabolic stress' to be submitted under Fifth Framework.

assistant: **Abstract**

This proposal aims to characterize the physiology and function of the long-TRP-channel LTRPC2 (TRPC7) in both normal physiological states and during neurodegeneration induced by metabolic stress. LTRPC2 is of particular interest because recent studies have demonstrated that the channel is permeable to calcium and activated by NAD^+, enabling the channel to sense the metabolic state of the cell and implicating this channel in mechanims of cell death. We will perform detailed investigations of channel physiology using recombinant cell lines expressing the human LTRPC2 channel. Electrophysiological characterization will be undertaken to study LTRPC2 channel properties with channel activation being confirmed using single cell imaging to enable direct measurement of intracellular free calcium levels to be made. Established 'array scan' cell death assays will be utilized to investigate the effects of LTRPC2 activation and potential modulators of this activity on cell signaling endpoints including MAP kinase and transcription factor activation states. This work will provide a fundamental insight into the functions of this important yet poorly characterized channel enabling us to test a novel hypothesis of cell death mechanism. The study of these channels may reveal exciting new therapeutic opportunities for neurodegenerative diseases such as Parkinson's and Alzheimer's disease. We aim to provide an extensive practical and theoretical neuroscience-training package to the research fellow. This will be enhanced by personal development plans offering a diverse range of excellent supplementary training courses covering general computing, communication skills and drug discovery. We will provide the fellows with a unique and exciting opportunity to undertake top quality research whil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The asymptotic theory of noise generation by rotating blade rows' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

At the University of Cambridge, Applied Mathematics, and under the supervision of Dr. N. Peake, I hope to study the interaction of vorticity with a rotating blade row of an aeroengine, enabling the prediction and understanding of the generation of sound of such engines. This three-year Ph.D. study could make a significant contribution to Europe's efforts to contain the aircraft noise pollution around its airports. Peake has developed solutions for the case that the blade row consists of flat, zerothickness blades. The proposed research aims at determining the effects of camber and thickness of the blades on the sound generation. The principle mathematical tool will be asymptotic analysis, although other analytical and numerical methods will also be applied to the fields of acoustics and unsteady aerodynamics.