RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Involvement of RAS signalling in TGF-ss1-mediated extracellular matrix synthesis relathionship between TGF-ss1 and angiotensin II'.

assistant: **Concept**

Systemic hypertension is one of the most prevalent diseases among the population of our country, and it also has a very big social and economic repercussion. Renal injury is one of its most important complications, and it is also one of the main sources of chronic renal insufficiency. Uncontrolled hypertension damages renal function by two basic mechanisms: intraglomerular hypertension and renal hypertrophy, leading to glomerular sclerosis by a common mechanism involving the action of autocrine or paracrine mediators like angiotensin II (All) and transforming growth factor ÿ1 (TGF-ÿ1 ). TGF-ÿ1 is very important in the mediation of this process, due to its role in the regulation of cellular proliferation, and also in the synthesis and degradation of extracell ular matrix (ECM). This cytokine seems to have an important role in the induction and development of interstitial fibrosis; its sustained expression induces chronic and progressive tissular fibrosis. TGF-ÿ systemic administration causes an elevation of the tissue levels of All, that also induces interstitial fibrosis in mesangial cells and in nephron tubular epithelium, causing ECM accumulation; moreover, All induces TGF-ÿ1 synthesis in mesangial cells, proximal tubule epithelial cells and vascular smooth m uscle cells. TGF-ÿ1 induces the expression of the prooncogenic GTPase Ras, and both molecules cooperate synergically in the progression of undifferentiated invasive tumours. TGF-ÿ1 enhances significantly the Ras mitogenic effects. However, Ras can also inh ibit cellular hypertrophy and ECM synthesis induced by TGF-ÿ1 signalling. Both TGF-ÿ1 and All induce the expression of connective tissue growth factor (CTGF), hypertrophie cytokine that maintains cells in d phase of the cell cycle. CTGF may be a mediator o f th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on '3D insulation bodies'.

assistant: **Concept**

The scientific and technical objectives of this research proposal concern the application of the unique thermal insulation, low density and high strength characteristics of the biological inert material calcium silicate to complex net-shaped insulation bodies. They can be used as components for consumer and industrial products as solar collectors and electronic devices housings. Research is required to characterise the material, to establish optimal material mixtures and to set-up effective production processes. Problems of resistance to climate influence are addressed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced imaging and measurement for multiphase flow' (AIMMF).

assistant: **Innovation**

The principal aim of the research is to develop a new generation of a non-invasive flow instrument for the measurement of flowrates and imaging of the internal structure of complex, unsteady two- or three-phase flows. The research is multi disciplinary covering the aspects of flow mechanics and metering, process tomography, signal processing and multi-variable data fusion. The instrument, based on electrical impedance tomography (EIT) sensors coupled with the principles of electromagnetic and Venturi flowmeters and density meter, will potentially be able to measure the volumetric flow rate and mean volume fraction of each phase in three-phase flows, to image time dependent distributions of the local 3D velocity vectors and volume fraction of the dispersed phase, as well as to visualise complex flow patterns, in which one of the phases is electrically conducting and other phases are electrically non-conducting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Supported human autonomy for recovery and enhancement of cognitive and motor abilities using information technologies', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The goal of SHARE-it is to develop a scalable, adaptive system of add-ons to sensor and assistive technology so that they can be modularly integrated into an intelligent home environment to enhance the individual's autonomy. The system will be designed to inform and assist the user and his/her caregivers through monitoring and mobility help. Thus, we plan to contribute to the development of the next generation of assistive devices for older persons or people with disabilities so that they can be self-dependent as long as possible. We focus on add-ons to be compatible with existing technologies and to achieve an easier integration into existing systems. We also aim at adaptive systems as transparent and easy to use to the person as possible. Scalability is meant to include or remove devices from the system in a simple, intuitive way. SHARE-it will address important issues in sensor networks, assisted mobility, knowledge engineering and Ambient Intelligence.In this context SHARE-it will make significant contributions to fundamental, long term research in the following two areas:C1: Verifying system adaptation to persons with special needs: both at design and run-time - as operating conditions and governing norms change - to establish e.g. safety, regulatory and security requirementsC2: Incorporating shared autonomy: ensuring individual components can be designed to operate in a given intelligent ambiance and adapt to possible changes both in the needs of the user or in the environmentObjectives of SHARE-it are:O1: To explore the benefits of the concept of situated intelligence to build elements (add-ons) that will enhance the autonomy of the target user group in their daily life in their preferred environmentO2: To investigate and implement innovative forms of shared auto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a device for electronic recording, localisation and identification of timber.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The presented project aims to develop an integrated system, which enables the recording and localisation as well as the identification of cut wood in an electronically way working in the field respectively in the forest. The development will enable the forest enterprises to control and handle the wood from the tree to the timber electronically. By this the timber can put very efficiently on to the wood stock markets such as Internet Stock Exchanges for timber. The intended device will consist out of three main modules(i) electronic recording device, (ii) electronic localisation device based on the GPS technique, (iii) electronic identification device based on e.g. the transponder technique. All modules must meet the rough conditions of the environment. By this the main RTD work is determined by different work packages : A.Basic development and analysis, B.Development of the modules and manufacturing of prototypes, C.Tests, trials and training/educating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Co-modality - towards optimised integrated chains in freight transport logistics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The KOMODA proposal is presented as an answer to the research objectives launched by call TPT 2007.2 concerning the optimization of the logistics chain through co-modality. More precisely, KOMODA’s objective is to produce a roadmap, with associated action plans, to nurture an integrated e-Logistics platform by and between modes of freight transport across Europe. Such platform must comply with a series of basic requirements: has to be based in open standards, usable by any concern, able to communicate freely between existing applications and allow the integration of legacy systems and future development. Several of such IT logistics platforms are currently in use, but mostly consist of private company applications not connected and not even compatible. For such developments, KOMODA will identify the industry requirements in terms of organization of the logistic chain and technical specifications of the integrated information system. Opportunities and obstacles affecting the future implementation of the e-Logistics integrated platform will be identified, resulting in the development of recommendations to empower the former and minimize the later. KOMODA will follow a bottom-up approach, with a strong involvement of freight industry stakeholders. The work will include a wide Delphi survey amongst the logistics chain stakeholders to obtain a comprehensive picture of available e-logistics applications used in transport operations, their sources, availability, functionality and use by companies. A desk research on transport and technical requirements will complement such exercise. Obstacles and opportunities will be identified for finally developing a structured and coherent action plan for innovation and change leading towards an integrated e-logistics system Europe-wide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Future RepAIR and Maintenance for Aerospace industry' (REPAIR) targeting Seventh Framework.

assistant: **Abstract**

The Project RepAIR will perform research on future repair and maintenance for the Aerospace industry. Therefore the onsite maintenance and repair of aircraft by in-tegrated direct digital manufacturing is in the focus of this project. The main objective of RepAIR is to shift the “make” or “buy” decision towards the “make” decision by cost reduction in the remake and rework of spare parts and therefore improve cost efficiency for maintenance repair in aeronautics and air transport. A crucial advantage of this technology is the flexible availableness (even at the gate) allowing on-time maintenance. Through a higher level of automation und fewer stages of production, less personal costs are necessary which therefore reduce the MRO costs. These operations require a higher qualification and promote the preservation and expansion of highly qualified workplaces in Europe. Moreover, the storage costs will be significantly reduced. As only the raw material needs to be stored, instead of having to have in stock up to 3.6 million spare parts for the multitude of airplanes and varieties of aircraft manufacturers, less capital is locked up. Additionally, hardly any energy – intensive produced raw material will be wasted or destroyed, but will be used optimally. When looking ahead, with the aid of AM technology, it will be possible to shorten the entire spare parts supply chain to sending an e-mail. The benefit for all those involved, including the environment, is obvious. New business models will become sustainable. Through a higher level of automation und fewer stages of production, less personal costs are necessary which therefore reduce the MRO costs. These operations require a higher qualification and promote the preservation and expansion of highly qualified workplaces in Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Characterisation of the Genetic Network Mediated by the Transcription Factor Pax6' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Pax6 is a selector gene responsible for modulating the fates of many distinct cell types, within several developing organs such as the eye, central nervous system and pancreas. The complex expression patterns and functions of Pax6 are achieved by tight re gulation, particularly at the level of transcription, of spatiotemporal and quantitative expression. A good illustration of the importance of Pax6 regulation are human eye anomalies caused by disruption of Pax6 transcriptional regulation as a result of de letions many kilobases (thousands of nucleotides) downstream of transcriptional termination at the polyA addition site. The Pax6 gene encodes a transcription factor that is highly conserved across species as evolutionarily distant as Homo sapiens, Drosoph ila melanogaster and Dugesia.tigrina. Pax6 has also been shown to be highly conserved, across mammals and more broadly across vertebrates, for genomic cis-regulatory sequences spanning 200 kb outside the transcribed gene. These two forms of conservation are good indicators that the functional genetic networks mediated by Pax6 are well conserved in evolution. The objectives of this project are to characterise the conserved elements extensively in different phyla (in insects, fishes, mammals and across ver tebrates). The aim is to reveal the dynamics of the Pax6 genetic network. To accomplish this we will combine the use of bioinformatics with lab experimentation on zebrafish and collaboratively in human, mouse and Drosophila. We will investigate the gene s that directly regulate Pax6 transcription and those which are immediate downstream targets of Pax6 using evolutionary information on cis-regulatory sequences of all the genes in the putative Pax6 network. Already known PAX6 interactors SOX2 and OTX2, al ready implic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of Novel ICT tools for integrated Balancing Market Enabling Aggregated Demand Response and Distributed Generation Capacity' to be submitted under Seventh Framework.

assistant: **Abstract**

The 3rd Energy Package clearly boosts the development of an Integrated European balancing mechanism. In this context, ACER has in 2011 started the development of the Framework Guidelines on Electricity Balancing.It is expected from the ACER statements that Demand Response will play significant role in the future integrated balancing market allowing Virtual Power Plants, comprising Demand Response and Distributed Generation resources to compete on equal ground.Based on the above, the overall objective of the eBADGE project is to propose an optimal pan-European Intelligent Balancing mechanism, piloted on the borders of Austria, Italy and Slovenia, that is also able to integrate Virtual Power Plant Systems that can assist in the management of the electricity Transmission and Distribution grids in an optimized, controlled and secure manner. Even if the trans-national mechanism proposed by eBADGE will be tested with reference to a trilateral case (Austria, Italy, Slovenia), the approach and the modelling methodology is meant to allow a gradual extension to other countries in Europe (such as Germany in a second phase).The ICT development of the eBADGE project will be in line with the ACER Guidelines delivering the following five results:\tSimulation and modelling tool for studying Integrated Balancing/Reserve Market allowing the participation of VPP at the distribution side;\tUniform high performance message bus between Balancing/Reserve entities;\tBusiness models between Energy, ICT and Residential Consumers sectors;\tVirtual Power Plant as a Reliable Balancing Asset;\tPilot eBADGE Cloud.Project objectives are:1.\tTo develop the components: simulation and modelling tool; message bus; VPP data analysis, optimisation and control strategies; home energy cloud; and business
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A new ERA for Environmental Risk Assessment: Chirality as a tool towards environmentally safe pharmaceuticals' (ERA-ARE).

assistant: **Concept**

The detrimental effects on ecosystems and human health caused by the emerging contamination of aquatic environment by pharmaceuticals urges a disruptive prevention strategy. These drugs, their metabolites and transformation products (TPs) are stable, poorly biodegraded, and recalcitrant. Though novel mitigation measures have been proposed, they are insufficient and often risky due to the possible generation of TPs. Under this increasingly deteriorating scenario for future generations, ERA|ARE aspires to build a strong ground for the realization of an internationally leading research group dedicated to promoting environmental safety. ERA|ARE approach is based on fundamental understanding of enantioselectivity of environmental processes that can impact the fate/behaviour of pharmaceutical contaminants. Fluoroquinolones (FQs), a group of chiral fluorinated antibiotics/anti-cancer agents will be explored as a proof of concept, since most small molecules approved in the last years are either fluorinated and/or chiral, presenting a stable CF bond and a potentially enantioselective bioactivity. To attain its goals, ERA|ARE will exploit the chirality of selected FQs as a piloting tool to: 1) realize the impact of stereochemistry on antimicrobial resistance (key innovation) by testing the hypothesis that antibiotic resistance (AR) may be acquired in (and not only spread/disseminated by) wastewater treatment plants (never verified before); 2) reveal how to better select drug candidates by biodegradability; 3) pave the way for future directions of Environmental Risk Assessment (ERA); and 4) avoid ecotoxicological effects and bioaccumulation. ERA|ARE will contribute to reduce AR (expected to cause 10 million deaths/year by 2050), raising the alert level for environmental protection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Personalized Neurostimulation Approach for the Treatment of Depression' (PLATOSCIENCE), addressing dissemination and exploitation.

assistant: **Impact**

Depression currently affects more than 300 million people worldwide, that is an increase of over 18% between 2005 and 2015. Moreover, 50% of major depressions are untreated in Europe, costing about €170Bn per year. Despite subject´s relevance, there are not any efficient nor customized treatment options, these falling often within conventional solutions (e.g. cognitive techniques), medication or neurostimulation techniques that do not acknowledge an individual rehabilitation for the patient. Platoscience has developed the world’s first plug n’ play device based on trans-cranial direct current neurostimulation (tDCS) for a personalised at-home treatment of depression. The patent-protected device, PlatoCure, consists of a portable neurostimulation headset with two programmable electrodes, easy to use and control, connected to an app to be tracked by health professionals and for cloud data collection and predictive analytics to improve individual treatment. PlatoCure also includes online neuroimaging by electroencephalogram (EEG) that enables measuring of electrophysiological data during stimulation. This yields a significant advantage of PlatoCure against competition, strengthening market introduction to become the standard treatment device for moderate to severe depression, yielding benefits for a large group of stakeholders, including patients, medical professionals, hospitals and clinics.The SME Ph1 will be crucial for: i) establishing partnerships with relevant stakeholders on an international level in the medical segment, ii) setting up a regulatory strategy and iii) developing a clear commercialisation strategy. Hereafter, PlatoScience will be able to start SME Ph 2 focusing on the clinical validation of the device with hospitals and clinics.Until the end of 2026, w