RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Reloadable Molecular Peptide Synthesizer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The sequence-specific synthesis of information-rich oligomers and polymers is achieved in nature through the operation of complex molecular machines that transcribe information from the genetic code. The most extraordinary of these ‘molecular factories’ is the ribosome, a molecular machine found in all living cells that assembles amino acids from transfer RNA (tRNA) building blocks into a peptide chain with an order defined by the sequence of the messenger RNA (mRNA) strand that it moves along. The Leigh group recently reported the design, synthesis and operation of a rotaxane-based small-molecule machine in which a functionalized macrocycle operates on a thread containing peptide building blocks in a pre-determined order to achieve sequence-specific peptide synthesis. Limitations of the first generation system include that it erases the sequence information on the strand as it is translated into the product. In this project I aim to protect the information during peptide synthesis in order to mimic multiple translation, the process through which protein is synthesized on the mRNA template by the ribosome. This will be achieved through a reloadable track strategy in which longer peptide chains than has previously been possible will be synthesized and the machine itself will be usable multiple times. Importantly, the peptide loading units are easy to attach and detach from the thread using hydrazone and Pd-metal complex ligand exchange reactions. Achieving a synthetic molecular machine that can do this specific task, i.e. synthesizing a peptide multiple times, will be a major advance in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecological diversity of land vertebrates through the largest extinction in Earth history' (ECODIV).

assistant: **Innovation**

Contemporary Earth’s ecosystems are threatened by accelerating extinction rates, but their responses to biodiversity losses are not detectable on short time scales. However, many large-scale biodiversity crises, or ‘mass extinctions’, occurred in the past and played a fundamental role in evolution. For instance, modern-style ecosystems originated from the worst biodiversity crisis in Earth history (PTME) at the Permian-Triassic boundary (~252 million years ago). The PTME killed over 70% of vertebrate species and created opportunities for new groups to diversify. After the extinction, Triassic land vertebrate assemblages were transformed, and new species diversified in ecological roles that were unexploited in Permian ecosystems. This suggests that extinctions may change the evolutionary trajectory of ecosystems and increase ecological complexity. Nevertheless, the ecological impacts of mass extinctions on ecosystems are still poorly understood. For the first time, this project critically investigates how the ecological structure and composition of land ecosystems changed across the PTME and its connection to biodiversity recovery. We will target the fossil record of exceptionally preserved Permian-Triassic ecosystems, alongside new field data from critical, but poorly sampled time intervals. Using a suite of novel approaches modified from modern ecology, we will quantify changes in ecological diversity, richness and stability of land ecosystems and major vertebrate groups. These patterns will be used to understand what factors drive biodiversity and the evolution of ecosystems during and after times of crisis. Through a comprehensive training and knowledge exchange programme, the experienced researcher and hosts will bring together and integrate their expertise in palae
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Joint action expertise: Behavioral, cognitive, and neural mechanisms for joint action learning'.

assistant: **Concept**

Human life is full of joint action and our achievements are, to a large extent, joint achievements that require the coordination of two or more individuals. Piano duets and tangos, but also complex technical and medical operations rely on and exist because of coordinated actions. In recent years, research has begun to identify the basic mechanisms of joint action. This work focused on simple tasks that can be performed together without practice. However, a striking aspect of human joint action is the expertise interaction partners acquire together. How people acquire joint expertise is still poorly understood. JAXPERTISE will break new ground by identifying the behavioural, cognitive, and neural mechanisms underlying the learning of joint action. Participating in joint activities is also a motor for individual development. Although this has long been recognized, the mechanisms underlying individual learning through engagement in joint activities remain to be spelled out from a cognitive science perspective. JAXPERTISE will make this crucial step by investigating how joint action affects source memory, semantic memory, and individual skill learning. Carefully designed experiments will optimize the balance between capturing relevant interpersonal phenomena and maximizing experimental control. The proposed studies employ behavioural measures, electroencephalography, and physiological measures. Studies tracing learning processes in novices will be complemented by studies analyzing expert performance in music and dance. New approaches, such as training participants to regulate each other’s brain activity, will lead to methodological breakthroughs. JAXPERTISE will generate basic scientific knowledge that will be relevant to a large number of different disciplines in the socia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PYREPAX – Past, present, and future of the Pyrenean pastures' (PYREPAX).

assistant: **Concept**

For centuries, the relationships between Pyrenean valleys were regulated by pacts called “pacerías”. These agreements were intended to maintain peace between valleys (hence their name, which derives from the Latin word “pax”), and to regulate the ownership and use of the natural resource which was at the basis of the Pyrenean communities: grassland. The pacerías between valleys on the same side of the frontier have received little historiographical attention, and their environmental dimension has barely been studied.PYREPAX focuses on the agreements regarding two mountain pastures in the Aragonese Pyrenees, Guarrinza and Cerbillonar. Each of them was a common of two valleys, the former of Ansó and Echo, and the latter of Panticosa and Broto. The project examines the pacerías, the practices associated with them, and their role in shaping the environment since the mid-eighteenth century. More widely, PYREPAX studies the reciprocal influences between society and nature, and the co-evolution of those relationships across time. The project intends to explain why and how the relationships between human societies and nature have changed by examining the evolution of the pacerías and the practices related to them.Furthermore, PYREPAX examines the current situation of the pastures and the communities from a historical perspective and through an interdisciplinary approach (ecology and environmental economy), by carrying out fieldwork, surveys, and interviews. In the last phase, the project will put into dialogue the ancient pacts with local actors, natural scientists, and regional management authorities with a view to redesigning some pacerías, thus creating permanent fora for debate based on interdisciplinary scientific knowledge, providing tools for bettter management of the pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cross-omics integration to identify modulators for improving vaccine efficacy' to be submitted under Horizon 2020.

assistant: **Abstract**

Influenza is a significant public health threat and vaccines are crucial for preventing infections at population-level. The efficacy of vaccination per individual, however, is highly variable. The causes for this broad variability in vaccine response between individuals remain poorly understood.   In this proposal, I hypothesize that genetic variants and their downstream pathways underlie the heterogeneity in vaccine response between individuals. This ERC project aims to for the first time, systematically investigate the interactions between genetic, non-genetic host and environmental factors, and the response to vaccination in order to build reliable models for predicting vaccine efficacy. The outcomes of this research will pinpoint key deterministic factors and identify modulators that can be used to improve vaccination strategies.   This project is based on the expertise that my research group has built up for identifying the downstream consequences of genetic variants, and for predictive modelling through integration of large cross-omics datasets. Given the rapid evolution of influenza virus, I will use seasonal trivalent inactivated influenza vaccines as prototype responses within two cohorts of 500 individuals from the Netherlands and 200 individuals from Germany. I will systematically generate, analyse, and integrate the cross-omics data (six layers of information from genome, epigenome, transcriptome, proteome, metabolome, and microbiome) with immune phenotypes (e.g. antibody titers, an important indicator of protection) using novel computational methods. This research will reveal the previously unknown cell-types, molecules, and pathways involved in vaccine-induced immune response and provide mathematical models for predicting individual variation in immune res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Seismic Imaging of the Solar Interior using space-based data'.

assistant: **Innovation**

The broad science objective of this proposal is to search for the root causes of solar magnetic activity by establishing connections and physical relationships between internal solar properties and the various components of magnetic activity in the solar interior and atmosphere. The physical processes inside the Sun are best studied with helioseismology, i.e. the observation and interpretation of solar seismic waves. Helioseismology is on the verge of a revolution with (1) the development of new techniques of data analysis and interpretation and (2) forthcoming observations by NASA’s Solar Dynamics Observatory (SDO, scheduled for launch in 2008), which represents a major technological step beyond the ESA/NASA SOHO mission: higher spatial resolution, higher cadence, and a complete view of the solar disk and the corona. I propose to develop an active program of research in local helioseismology, a relatively young science. New methods of analysis will be developed to make 3D images of the solar interior and to infer the subsurface structure of sunspots using full-waveform modeling techniques. In order to take full advantage of space-based observations, I propose to establish a computing center for helioseismology at the Max Planck Institute for Solar System Research, which will provide the infrastructure and the manpower required to process the relevant SOHO/MDI and SDO/HMI data and to deliver original science data products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Control and Sensing for Sustainable Operation of Flexible Intensified Processes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Intensified continuous processes are a key innovation of the last decade for the production of high quality, high value and customer-specific products at competitive prices in a sustainable fashion. To realize the potential of this technology, key steps must be made towards long-term stable, tightly controlled and fully automated production. The goal of the CONSENS project is to advance the continuous production of high-value products meeting high quality demands in flexible intensified continuous plants by introducing novel online sensing equipment and closed-loop control of the key product parameters. CONSENS will focus on flexible continuous plants but the results will be transferable also to large-scale continuous processes. The research and development is driven by industrial case studies from three different areas, spanning the complete value chain of chemical production: complex organic synthesis, speciality polymers, and formulation of complex liquids.Innovative PAT technology will be developed for online concentration measurements (mid-resolution process NMR), for the online non-invasive measurement of rheological properties of complex fluids, and for continuous measurements of fouling in tubular reactors. New model-based adaptive control schemes based on innovative PAT technology will be developed. The project results will be validated in industrial pilot plants for all three types of processes, including validation in production containers that have been developed in the F3 Factory project. Further, methods for sensor failure monitoring, control performance monitoring and engineering support for PAT-based solutions will be developed.The exploitation of the new technologies will be facilitated by a tool for technology evaluation and economic impact assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Green synthesis of sustainable BIO-sourced multi-functional ingredient for skin CARE applications' (BIO4CARE).

assistant: **Concept**

Nowadays, cosmetics and personal care products are considered essential commodities of our life. However, the growing concern about the environmental impact and human health risk related to the excessive use of chemical ingredients in skin care formulations calls for the exploration of safe and sustainable natural alternatives. The diverse functional and bioactive properties of lignin make it worthwhile to be considered for cosmetic applications. Moreover, lignin is generated as an undervalued by-product from kraft-pulping operations, the most widespread method for pulp manufacture worldwide. The BIO4CARE project tackles challenging concepts with innovative solutions to develop an efficient lignin-based multi-functional ingredient with understood and controlled properties from kraft lignin for skin care formulations. To the best knowledge of the Experienced Researcher (ER), no prior research on using kraft lignin as a multi-functional ingredient to manufacture a novel and bio-based competitive solution for skin photo-protection has been reported. The BIO4CARE project comprises multi-disciplinary tasks and addresses different research areas such as analytical and applied chemistry as well as physics and biology to achieve the specific objectives of the project. The main objectives of the project are production of homogeneous lignin nanoparticles (LNP) by a sustainable and efficient method, optimization and understanding of nanostructure-properties relationships using powerful analytical tools, manufacture of high-quality Pickering emulsions with LNP and assessment of multi-functionality and toxicological profile of LNP. In addition, through MSCA program activities, the ER will gain research and scientific skills and acquire a new set of competences to reach professional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-national network of excellence for research on genetic predisposition to cardio-metabolic disorders due to UCP1 gene polymorphisms' (U-GENE) targeting Seventh Framework.

assistant: **Abstract**

Cardio-metabolic disorders (CMD) represent a heavy public health burden for Europe which has one of the highest adult mortality rates in the world, primarily due to a very high incidence of CMD. The 2011 FP7 Health Work Programme included three Calls targeted specifically on understanding CMD nature and pathophysiology, while the World Health Organization Regional Office for Europe recently recognised CMD as the greatest public health challenge of the 21st century. The aim of this proposal is to create a multiannual joint programme of collaboration between eminent research entities based in EU or Associated Countries (EU/AC) and Eastern Europe and Central Asia (EECA) countries for investigating the prevalence of uncoupling protein one genetic polymorphisms and their impact on predisposition to CMD. Thus, U-GENE fits perfectly within the scope of IRSES which aims in establishing long-term research cooperations through coordinated joint programmes of balanced research staff exchanges in thematic areas that are relevant to the European population. In addition, the EECA region is of strategic importance to the EU, in both economic (trade, energy) and political (security, stability) terms. The U-GENE partners boast an outstanding group of researchers, extensive collaboration and knowledge transfer networks, a large number of relevant publications, as well as very active participation in research programs funded by the European Commission. Moreover, the partners’ experience and specialisation in CMD research, their extensive experience in networks of excellence and international collaborations, and their broad infrastructures will provide the level of quality required to transform the U-GENE joint exchange programme into a successful multi-national network of excellence for C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The detection of gravitational waves' under Fourth Framework.

assistant: **Concept**

Research objectives and content The detection of gravitational waves from astrophysical sources is probably one of the most keenly awaited events in the history of astrophysics. Our purpose is to study phenomenological aspects of gravitational radiation detection and to develop techniques for analyzing data. Our study will be primarily devoted to binary systems and pulsars which are among the most promising sources of the gravitational waves. We will work in the development of more efficient algorithms for the choice of an optimal set of templates to detect a known waveform buried in noisy data. We will investigate such techniques with the aid of differential geometry which provides geometric insight into the problem. Another problem is that the search for long-lived binary systems and pulsars involves making corrections for Doppler effects from the motion of the Earth. These corrections must be done differently for different places on the sky. This gives detectors good angular resolution but presents formidable data-analysis problems because there are 1013 different resolvable positions on the sky in a 1-year observation at 1 KHz. This is important because these sources may be the first to be seen by ground-based detectors. Training content (objective, benefit and expected impact) The training aspect of this proposal focuses in getting a deeper knowledge in the main scientific area of the applicant to acquire new methods and techniques or analysis for the problem described and to learn and apply various computer languages and computer algorithms for parallel processing. Links with industry / industrial relevance (22)