RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'disruptive capturing and revalorisation system of AMmonia for BIogas plants ENhancing Circular Economy' (AMBIENCE), addressing dissemination and exploitation.

assistant: **Impact**

94% of ammonia (NH3) emissions in Europe stem from agriculture. Thus, EU has created a Directive, forcing exploitations to assume important costs for properly manage theexcretions generated as a daily basis. The market opportunity for Biogas Plants, to apply local innovative business models with a low-cost affordable solution, to biogas digestate,reducing environmental risks transforming it into Ammonia Sulphate (NH4)2SO4. This is an expensive product nowadays, that could be monetized through fertilizers manufacturers, thus generating a second business opportunity while boosting a circular economy.AMBIENCE consists of a low-cost close-loop physical system based on a novel and highly efficient technology of permeable membranes that capture the ammonia in between 70% - 80%, from the emissions (liquid and gas) generated by animal waste and pig farms, and biogas plants’ digestants.AMBIENCE delivers a processed ammonia (NH3) turned into Ammonia Sulphate (NH4)2SO4, prepared to be easily treated by fertilizers manufacturers reducing farmers’ operational costs by means of both savings and new incomes achieved (+60%) by applying this innovative revalorisation business model. If all the farming and stock sectors would apply AMBIENCE solution more than 65% of ammonia worldwide emissions would be avoided.Phase 1 objectives is to accelerate the market adoption and international penetration of AMBIENCE focus on preparing ourselves for the commercialization of at the international level (including route-tomarket, marketing strategy, growth strategy, etc.) by evolving the product from TRL6 to TRL9 stageAs a result of this project, AMBIENCE will grow considerably, generating 35 new qualified jobs by five years after the project ending and generating incomes of 46.8 M€ and a EBITDA of 21
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'InnoBremen2 – Establishing services enhancing the innovation management capacities of SMEs in the Federal State of Bremen' (InnoBremen2), addressing dissemination and exploitation.

assistant: **Impact**

The following proposal addresses the topic “Specific activities in the context of innovation support (Horizon 2020)“, namely the in-depth services enhancing the innovation capacity of SMEs, i.e. “Key account management under the SME Instrument of Horizon 2020” and “Services to enhance the innovation management capacities of SMEs”. Innovation is a key driver for the success of enterprises, a requirement for their competiveness and thus a precondition for exploiting international opportunities in the Single Market and beyond. Offering growth-oriented business and innovation support services to SMEs is therefore seen as the core task of the Enterprise Europe Network.Although Innovation Management is crucial for SMEs, empiric data has proven that SMEs still show the inability to manage innovation processes efficiently and effectively as the second most important barrier to SME innovation.Enterprise Europe Network Bremen will offer the services- Key account management under the SME Instrument of Horizon 2020 and- Services to enhance the innovation management capacities of SMEsas an integral part of the Enterprise Europe Networks services addressing the innovation needs of SME’s to establish an Innovation Management System (basis: technical specification CEN/TS 16555-1, published by the European Commission) in the respective enterprises. Beneficiaries of the services will be:1. Beneficiaries of the SME Instrument2. SMEs with significant innovation activities and a high potential for internationalizationnamely by offering the provision of innovation and technology audits and technology transfer partnering services.


**Keywords:** innovation capacity, innovation management, innovation services, KAM services, SME instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart INitiative of cities Fully cOmmitted to iNvest In Advanced large-scaled energy solutions' (SINFONIA), addressing dissemination and exploitation.

assistant: **Impact**

SINFONIA utilizes EU funds to bolster public/private resources and provide European added value to already committed district refurbishment master plans of two middle sized European cities (Bolzano, Italy and Innsbruck, Austria), the targeted performances of which combine three key features thanks to industry involvement: i) unique cooperation between the cities belonging to the same climate zone in Europe, but working under different regulatory regimes (Austria, Italy), ii) single collective ambition in reducing energy needs to meet human activity requirements, and the related CO2 emissions (40 to 50 % primary energy savings per district, 20 % increase of the share of renewable energy uses), iii) several innovations in network infrastructures and technology interfaces that enable smarter use of energy at district level, a stepping stone to guarantee a reliable and progressive transition toward low carbon cities. Moreover, SINFONIA aims at validating a comprehensive, interdisciplinary, refurbished city district model where the potential for scalability and replication by middle-sized European cities is built and validated during demonstration, based on energy technologies deployed by the two pioneer cities. This model emphasizes the role of an innovative integrated energy system approach, linking energy efficiency and CO2 abatement. The model robustness is reinforced by five “early adopter” cities which are full project partners in Cyprus (Pafos), France (La Rochelle), Germany (Rosenheim), Spain (Sevilla) and Sweden (Borås). They use the tested scalability and replication rules to reinforce their impacts on the five future city district refurbishment processes, thus showing that district renovation can be prepared under different sizes, climate and regulatory conditions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integration of in vitro approaches to predict drug metabolism and interactions in man in development of pharmaceuticals' (1994-1998) under Fourth Framework.

assistant: **Objectives**

To integrate in vitro tests or models, based on human liver-derived systems. for predicting the metabolism and metabolic interactions of drugs and chemicals which are likely to occur following their exposure in man and compare these with results in vivo.Detailed knowledge of the metabolism of pharmaceuticals is essential as early as possible in the research and development process, for two main reasons. The metabolism of drugs is generally the major determinant of their pharmacokinetic behaviour, interindividual variability and interactions with other compounds, all factors that complicate drug treatment. Differences in metabolism are also very often responsible for difficulties in extrapolating from a toxicology test species to humans, which can be a serious obstacle in drug testing and development.A large number of approaches, based largely, but not solely on human-derived systems, for the prediction of drug metabolism are under development, although not all areas are as well advanced as some. The project will involve the selection or development of suitable model substances and reagents which will be used to define rigorously the various candidate in vitro methods and approaches, the application of the most promising methods and approaches to existing drugs and substances under development, i.e. real" compounds from the participating industrial laboratories, and a comparison of the predictive power of these approaches to metabolism in vivo, determined in volunteers. The likely outcome is the identification of suitable tests, and the development of an integrated approach to the prediction of the metabolism of drugs. This could be used in drug discovery, in the design and execution of toxicity tests and of early clinical trials.Other major tangible benefits will accrue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Closed-loop Molecular Environment for Minimally Invasive Treatment of Patients with metastatic Gastrointestinal Stromal Tumours' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Gastrointestinal stromal tumours (GIST) are a rare disease that metastasises in up to 85% of patients with subsequent median progression-free survival (PFS) of only around 30 months. Tumours are characterised by activating mutations in the KIT or the PDGFRA gene and therefore treatment is mainly based on tyrosine kinase inhibitors designed to block these mutated receptors. However, drug resistance is often based on mutations changing the conformity of the receptor, leaving little effective therapeutic options to these patients. To date, second line chemotherapy offers a median PFS of 6-9 months and external beam radiotherapy is limited by organs at risk close to the tumour. Alternative approaches such as endoradiotherapy or minimally-invasive ablation techniques are effective for local control but are inconsistently used and are not tailored to the individual patient's type of disease. To address these issues, we propose a closed-loop personalised treatment concept combining endoscopic-assisted tissue sampling, inline biotechnology and targeted molecular PET imaging probe development combined with minimally-invasive treatment monitored by new functional and metabolic MR imaging techniques. A consistent value chain across European academic centres, research institutes and SMEs will be established for mass spectrometry of tumours, linkage of radiochemical molecular imaging probes, design of new immunocompromised animal models and targeted therapeutic radiopharmaceuticals. This closed-loop platform will minimise fragmentation of treatment approaches by a coherent molecular-based multimodality concept, thus providing new treatment options. On a larger scale, the MITIGATE platform can be expanded to further patient cohorts with oligometastatic diseases such as other sarcomas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Combined indoor/oudoor Wireless Network Planning' (CWNETPLAN) targeting Seventh Framework.

assistant: **Abstract**

Wireless communications technologies have experienced some of the fastest technological innovations in the last few decades. In the near future, a large portion of the access network will go wireless. It is estimated that 2/3 of voice and over 90% of data services using wireless communications take place indoors. Hence, indoor solutions like picocells (indoor base stations) deployed by the operators, or femtocells (indoor home base stations) deployed directly by the users, have been recently proposed. While these new indoor solutions can bring a lot of benefits for both operators and users, they have undesirable impacts on outdoor networks as well due to the interferences between indoor and outdoor. With the increasing number of indoor solutions (For example there could be about 70 million femtocells installed in homes around the world serving more than 150 million users by 2012 according to ABI), the study of the interactions between indoor and outdoor network simulation, planning and optimisation has become an extremely timely and important issue. The aim of this proposal is to solve the problem of combined indoor/outdoor wireless network planning and optimization, to be able to plan a network, taking into account both the indoor and the outdoor networks. This project can be divided into three main tasks. First, a combined indoor/outdoor propagation model must be proposed in order to compute the received signal and then evaluate the interferences. Then, a combined indoor/outdoor optimization method is necessary, to find what are the parameters of the network (position of the emitters or output power for example) that maximize the performances of the network (data rate or quality of service for example). Finally, an automatic model calibration method must be developed,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Alpha-immunotherapy and cell toxicity' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Specific Objectives 4.1.1.1. Production of Radionuclides and Radiolabelling of biomolecules Production of bismuth-213 for preclinical experiments (and phase I) Consulting/training of Ac-225 production (outsourcing) New alpha-emitters for radiotherapy Evaluation of the Ytrium-90 production for radioimmunotherapy Contribution to EMIR To synthetise new chelators for actinium and radium To conjugate chelates for biomolecules Testing new radiolabeled biomolecules 4.1.1.2. Radiobiology Gene activity variation after alpha, beta, gamma irradiation in leucemic/normal cells Establishing a cell model for Bystander/hormesis effect Functional test for studing cytotoxicity in normal and leucemic cell lines.Planned Deliverables 4.1.1.1. Production of Radionuclides and Radiolabelling of biomolecules Bismuth-213 generators for hospitals License contract with an external company to produce Ac-225 in the cyclotron A method to produce radium-224 for preclinical and (clinical use) Yttrium-90 for preclinical and (clinical use) Contribution to EMIR Bifunctional OHEC as chelate for Ac and bifunctional Calixarene-crown ether for Ra Chelated antibodies for preclinical use (also consulting hospitals to do clinical grade material) A method to determine stability constants 4.1.1.2. Radiobiology Basic data of alpha, beta and gamma radiation effects in leucemic/normal cells A Model to study bystander effect Effects of the gene activity to function of the cell.Summary of the Action: The objective of the work is to develop, test, validate and optimise a drug against different types of cancers, consisting of a suitable alpha-emitter, a cancer specific carrier (antibody, peptide, etc.) and a chelator (combining nuclide and carrier). For this purpose ITU focuses on: the consultation and training to licens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Adequate information management in Europe' (AIM) targeting Sixth Framework.

assistant: **Abstract**

The project Adequate Information Management in Europe aims at investigating the media's impact on the European public sphere with regard to actors (media institutions and organisations on European, national, regional and local levels as well as journalists , correspondents and editors etc.) and mechanisms (EU news management processes). In the centre of attention will be how the mass media manage and produce positive and negative EU coverage and assessment in the context of diverse journalistic and editorial cultures, standards and ethical considerations in Europe. The project is based on two levels: First, it examines the practical conditions that determine if a European issue is set on the news agenda or not. Secondly, it deals with the normative approach, that only the access to EU information and its plurality can provide a basis for democracy and a European public sphere as well as in a further step a breeding ground for active civic participation, European citizenship and identity and for public governan ce. This is also linked to the aim to enhance the openness, transparency, accountability and legitimacy of the political system of the EU and may not only concern an elite group of intellectuals, but moreover the European peoples without distinguishing bet ween gender, age, class and ethnicity. The achievements and shortcomings concerning mass media structures and performances are of crucial importance to define the state of development of a European public sphere and to create standards to overcome the hurd les while taking the information inflow by the European institutions and organisations as well as the audiences' needs and expectations seriously into account. All this will be analysed by a consortium of researchers of EU states, candidate countries and n on-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Harnessing clonal evolution in chronic lymphocytic leukemia' to be submitted under Horizon 2020.

assistant: **Abstract**

Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is addicted of interactions with the microenvironment. The B-cell receptor (BCR) is one of the most important surface molecules that CLL cells use to gain oncogenic signals from the microenvironment. The critical role of BCR signaling for the pathogenesis of CLL is supported by the therapeutic success of ibrutinib, a targeted agent that disrupts the BCR pathway. Beside microenvironment-promoted oncogenic signals, the biology of CLL is also driven by molecular lesions and clonal evolution, that mark CLL progression and treatment resistance. The interconnection between microenvironment-promoted oncogenic signals and clonal evolution has been postulated in CLL but never proven because of the lack of suitable ex vivo models. Ibrutinib allows the unprecedented opportunity of assessing the contribution of cell signaling to cancer clonal evolution directly in vivo in patients. The project working hypothesis is that mutation- and selection-driven clonal evolution is promoted by microenvironment-induced signals, including those propagated from the BCR. According to this hypothesis: i) BCR signaling inhibition due to ibrutinib should stop clonal evolution; while ii) acquisition of by-pass mechanisms that keep ongoing signaling should promote mutation and selection despite BCR inhibition, thus favoring CLL clonal evolution and ibrutinib resistance. In this scenario, the combination of ibrutinib with drugs that overcome by-pass mechanisms could prevent clonal evolution, thus improving treatment efficacy and patient outcome. In order to address our working hypothesis, we will take advantage of clinical trial and co-clinical trial samples to monitor signaling and clonal evolution under ibrutinib and ibrutinib-bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Research and graduate studies in economics at bocconi university' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Applications are invited for fellowships in the 2002 calendar year at IGIER, Bocconi University, under Marie Curie Training Site Scheme. These fellowships allow doctoral students in economics in countries other than Italy the opportunity to pursue research in Milan and to interact with other researchers. Doctoral students belonging to partner universities affiliated to the EDGE network are particularly encouraged to apply. The fellowships may be held for periods of between 3-12 months. The Faculty aims to award up to 4 fellowships for the 2002 year, depending on the overall quality of the applications. Research fields: economic policy, monetary policy, public finance, industrial policy, labor economics, international economics, and industrial organization. Successful applicants will be fully involved with the Faculty of Economics at Bocconi University and with the day-to-day life of IGIER. They will follow courses in doctoral programme, attend seminars and research workshops and work with a senior research supervisor from the teaching staff. Applicants must be nationals of a Member or Associated State of the European Union, or be able to provide proof of having resided in Member States for at least the last 5 years before their application. Applicants may be at any stage of their doctoral studies in economics; they must indicate how their doctoral research will benefit from a stay at Bocconi University. Applications should include: full CV; statement of the proposed research to be done, with details of how this relates to the applicant' s doctoral studies; names of two referees, one of whom should be the supervisor of the applicant's doctoral studies. Deadline for applications: Monday November 20, 2001. Referees have to write directly to Angela Baldassarre, Bocconi Univ