RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Literature and the “First East Asian War” of 1592-1598 (EURO-IMJIN)' to be submitted under Horizon 2020.

assistant: **Abstract**

This project will locate, transcribe, translate, and analyse European accounts of the East Asian War of 1592-1598 (“The Imjin War”), connecting European and East Asian research on the war and opening new horizons for researchers from both regions. The applicant is a specialist of seventeenth century European literature with four years experience teaching and researching Spanish literature at universities in China and Japan. The applicant will build upon his current skill set by receiving Asian history, language, and translation training with a unique team of specialists at the host institution (Universitat Autònoma de Barcelona). This will provide him with a solid foundation for his future research trajectory on the literature of East-West encounters in Asia. Ultimately, the applicant aims to use this opportunity to obtain a permanent academic appointment back in Europe, bringing his knowledge and networks from Asia.


**Keywords:** Spanish Golden Age literature, Chronicles, Missionaries in Europe, East Asian history, Global history
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanostructured materials and RF-MEMS RFIC/MMIC technologies for highly adaptive and reliable RF systems' (NANOTEC).

assistant: **Innovation**

RF communication and remote sensing (radar/radiometric) systems are facing the demands ofincreasing complexity/number of frequency bands, increased bandwidths and higher frequencies forhigher data throughput, while at the same time the power consumption, the form factor of the systems,and the overall system costs need to be reduced. Smart micro-/mm-wave systems will have to achieveself-reconfigurable operations for real-time efficient self-optimization of their performance. For suchadaptive systems, high-performance tuning components and strategies for buildingmonolithically integrated miniaturised reconfigurable RF circuits/front-ends are highly needed.The NANOTEC project aims to generate innovative approaches towards novel RF/mm-wave systemswith increased functionality and potentially lower cost addressing future needs of European industry.NANOTEC will develop 3 Demonstrators (1: 10-24 GHz reflect arrays for aerospace, 2: 94 GHz highsensitivity front-ends for passive imaging and 3: 140 GHz radar front-ends for active imaging) with advanced functionalities based on enabling technologies and via monolithic integration of highperformance RF-MEMS switches in GaN/SiGe IC foundry processes. NANOTEC will aim toimprove reliability of RF-MEMS by using NANO structured materials and to demonstrate addedvalueby employing the proposed GaN/SiGe MEMS-ICs for 10-140 GHz applications. Theemergence of European sources (SiGe/GaN MEMS-IC foundries) will play a key role towardsincreasing the availability of RF-MEMS TEChnology and related products (thus shortening the timeto-market). If successful, NANOTEC will also lead to improved safety/security thus creating novel business opportunities/jobs for existing/new companies in Europe. The NANOTEC consortiumconsists of 17 partners (7 countrie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systematic in-vivo analysis of chromatin-associated targets in leukemia', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Recent advances in genome sequencing illustrate the complexity, heterogeneity and plasticity of cancer genomes. In leukemia - a group of blood cancers affecting 300,000 new patients every year – we know over 100 driver mutations. This genetic complexity poses a daunting challenge for the development of targeted therapies and highlights the urgent need for evaluating them in combination. One gene class that has recently emerged as highly promising target space are chromatin regulators, which maintain aberrant cell fate programs in leukemia. The dependency on altered chromatin states is thought to provide great therapeutic opportunities, since epigenetic aberrations are reversible and controlled by a machinery that is amenable to drug modulation. However, the precise mechanisms underlying these dependencies and the most effective and safe targets to exploit them therapeutically remain unknown.Here we propose an innovative approach combining genetically engineered leukemia mouse models and advanced in-vivo RNAi technologies to explore chromatin-associated vulnerabilities at an unprecedented level of depth. Following a first screen in MLL-AF9;Nras-driven AML, which led to the discovery of BRD4 as a promising therapeutic target, we aim to (1) construct a knockdown-validated shRNA library targeting 520 chromatin regulators and use it to comparatively probe chromatin-associated dependencies in diverse leukemia subtypes; (2) explore the mechanistic basis of response and resistance to suppression of BRD4 and new chromatin-associated targets; and (3) pioneer a system for multiplexed combinatorial RNAi screening and use it to identify synergies between established and new chromatin-associated targets. We envision that this ERC-funded project will generate a comprehensive functiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'QUantum Electronics Science and TECHnology training' under Horizon 2020.

assistant: **Concept**

Quantum Electronics provides a challenging and innovative multidisciplinary framework for training young researchers with excellent prospects for a career either in the industry or in academia. In this promising area, the “Quantum Electronics Science and Technology training” project, with acronym QuESTech, will create a European network of experts providing state-of-the-art training for young researchers in the general field of experimental, applied and theoretical Quantum Electronics.The overarching science and technology goal of our research programme is to build, study, and qualify quantum electronic devices. QuESTech will train 15 ESRs through research in the sub-fields of spintronics, single-electronics, quantum dots, and quantum thermodynamics. The individual research projects will include technological developments in terms of nanomaterials growth, nano-structuring, near-field microscopies, transport measurement under extreme conditions and theoretical calculations. Several QuESTch results are already identified to be of commercial interest for the emerging Quantum Electronics industry.Systematic secondments will be organised, including for every researcher a secondment of two months to a private sector partner. QuESTech will organise three sessions of the European School On Nanosciences and Nanotechnologies (ESONN) devoted to Quantum Nano-Electronics, combining both theoretical and practical training, and open them to young researchers outside the consortium. By 2021, we aim to have prepared a new generation of young researchers able to address the emergence of “Beyond C-MOS“ nano-electronics.


**Keywords:** Quantum electronics, quantum thermodynamics, quantum dots
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Soft Organic Electrochemical Neurons for Biochemical Sensing and Delivery' to be submitted under Horizon Europe.

assistant: **Abstract**

Recent advancements in prosthetics, brain-computer interfaces, and neural therapy require electronics that communicate with biological systems. However, electronic circuits manipulate 1/0 binary digits, whereas biological neurons function with ion flux-induced neural spikes. To emulate biological neuron functions in hardware implementations, artificial neurons have been developed using inorganic memristors or transistors, but they have failed to integrate with biotic neurons due to their high operating voltage and inherent inertness towards ion/neurotransmitter-based modulation. In this regard, organic electrochemical transistors (OECTs) distinguish themselves by using ionic species to mediate electron/hole conductance in organic semiconductors, making them the ideal candidate for fabricating organic electrochemical neurons (OECNs) with high biocompatibility and biochemical-mediated functionalities. So far, OECNs have been demonstrated by the project host (Prof. Simone Fabiano at Linköping University) with the capability to emulate biorealistic spiking patterns, response to exogenous ions or neurotransmitters for spiking modality alternation, and perform event-based neuron stimulation in animal models. However, existing OECNs still face two major limitations that impede their integration with biological nerves, including their rigidity and incapable of performing endogenous biochemical sensing and modulation with biotic neurons. To exploit the advantages of OECNs for bio-integration and bidirectional communication, I will use my expertise in soft materials, devices, and systems to devise OECNs with tissue-like softness, monolithic assembly, and seamless integration with biological nerves. Specifically, stretchable organic semiconductors and other soft constituent materi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deep partial melting of subducted carbon and the formation of sub-lithospheric diamonds and their mineral inclusions' (DEEPCARBON).

assistant: **Concept**

The key aspect of the Earth’s deep carbon cycle is how exogene carbon is recycled into the deeper earth via subduction of altered, carbonated, mafic oceanic crust. We aim to use ultrahigh-pressure experimental petrology to investigate the behaviour of subducted carbonate at pressures corresponding to the deep upper mantle, the mantle transition zone and the uppermost lower mantle. Earlier experimental studies showed that some residual crystalline carbonate in oceanic crust remains stable in subducting oceanic crust without decarbonation or melting, and may be transported to very deep levels in the mantle. It may form carbonate eclogite in the upper mantle and carbonate garnetite in the transition zone and uppermost lower mantle. How far carbon can survive this journey to extreme depths depends on the relationship between the pressure-temperature path followed by deeply subducting carbonated oceanic crust and its melting relations and solidus temperatures. We aim to use multi-anvil experimentation at the University of Bristol to determine melting relations in the deep upper mantle, transition zone, and uppermost lower mantle (9-21 GPa) of carbonate eclogite. We will explore the influences of pressure, temperature, oxygen fugacity and key bulk compositional variables such as Na2O/CO2 on very deep subduction of carbonate and on the volumes and compositions, and fates of carbonated partial melts. Fundamental research outcomes will include understanding of (1) the role of bulk composition in determining melting temperatures of deeply subducted, carbonate-bearing oceanic crust, and hence how deep carbonate melting can occur (2) how these carbonate melts interact with surrounding ambient peridotite mantle and what sort of geochemical sources and deeply derived magmas/fluids co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structure and electronic properties of low-dimensional systems and molecular assemblies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Low-dimensional structures and molecular assemblies in the nanometre range exhibit an enormous potential for applications in future electronic data storage and processing devices. Such structures are particularly interesting when created through the process of self-assembly on suitable substrates. Vicinal surfaces are ideally suited as patterned templates for the mass fabrication of one-dimensional structures on the nanometre scale, where conventional lithographic techniques are no longer feasible or afford able. Vicinal surfaces display a two-fold symmetric morphology and, consequently, a complete anisotropy of all physical properties that is retained upon atom or molecule adsorption and thin-film growth. Furthermore, one-dimensional patterns of steps, facets and atomic rows with periodicities on a scale of 1nm to 100nm can be produced.We will investigate the structure and electronic properties of(i) low-dimensional structures (quantum wires, dots, and stripes) and(ii) molecular assemblies of periodic structures prepared on vicinal semiconductor and metal substrates.Our interests are specially centred on the formation and final structure of atomic or molecular chains and their corresponding electronic structure. In the latter case we will focus on the reconstruction of the electron wave functions and the temporal evolution of quasi-particles (holes and electrons), characterised by a finite lifetime that can be analysed by scanning tunnelling and photoemission spectroscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Evolution and Function of Ancestral Brain States' in the context of a Horizon 2020 call.

assistant: **Objectives**

One of the oldest enigmas in neuroscience is the function of brain states. During these states, dramatic transitions occur in the firing patterns of neurons in the cerebral cortex. These transitions are correlated with behaviour during wakefulness but, strikingly, are even more prominent during sleep, when interaction with the environment is limited. The similarities between sleep and awake patterns remains unexplained, thus complicating our understanding of the global function of brain states. Additionally, state transitions are prominent in both the cortex and hippocampus, but the interplay between these areas during different states remains ambiguous. Why is the function of brain states so elusive? A likely explanation is that state transitions are inextricably intertwined with many other processes, rendering their dissection difficult.This project is motivated by the notion that to understand brain states we need to: a) examine them in a simpler model system, b) understand how they evolved, c) identify which state properties are fundamental and which are species specific. I suggest that studying brain states in the cerebral cortex of reptiles offers a unique opportunity for achieving all three goals.We will utilize the simpler and highly structured state organization in Pogona Vitticeps, to expose the full repertoire of brain states in a naturally behaving animal. We will take advantage of the limited diversity of motor movements in Pogona, to expose the link between population patterns and defined behaviors. We will furthermore exploit the unique evolutionary positions of reptiles as closest to stem amniotes, in which the layered cortex and hippocampus first emerged, to reveal the forces that pushed the emergence of brain states in evolution. Finally, through a com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Risk assessment and integrated ochratoxin a (ota) management in grape and wine'.

assistant: **Concept**

Trans-European populations of OTA producing fungi will be identified and characterised, their infection cycle will be described, especially in relation to their ecological requirements. In order to define the sources of contamination, the ecological conditions favourable for fungal infection and OTA production will be described and possible preventive actions will be studied. Corrective action will also be taken into account during grape storage and/or processing. Field data will be processed following a geostatistical approach for draw risk maps. Decision Support System (DSS) will be elaborated to optimise preventive actions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Naturally processed peptides derived from the human acetylcholine receptor. Clues for myasthenia gravis immunotherapy.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content - a doubling of the global atmospheric Cø2 concentration and associated, more local changes in climate predicted from General Circulation Models to occur across Europe over the next 100 years will not be detrimental to European forests. Subsidiary hypotheses to be tested are that: - impacts of elevated CO2 and temperature will be limited by availability of nitrogen in northern temperate and boreal forests and by availability of water in Mediterranean forests, and - a delicate balance between gains of carbon by CO2 assimilation and losses by tree respiration and microbial oxidation of soil organic matter determine carbon sequestration in stands and may be tipped one way or the other by rising CO2 and temperature. The primary focus is on stands of the ecologically and environmentally most important trees and forests across Europe. The methodology is to model the CO2 and water exchanges, carbon sequestration and water use, growth and production of forest stands using mechanistic, bottom-up models that contain explicit representation of the processes that are affected by rising CO2 and temperature. The work is focused on the rationalisation, convergence, parameterisation and validation of the suite of models in current use and their application to predicting the likely impacts at stand scale. Upscaling to landscapes and longer time periods will take account of recent knowledge regarding feedbacks but is more speculative. Parameterisation will utilise previous experimental work and will be reinforced by new integrated experimental programmes of ecophysiological measurements in chambers and forest canopies. Validation will be achieved by comparison of predicted fluxes with measured fluxes in today's climate and by comparison of predicted impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Antibody-Mediated Therapy of HIV-1 Infection'.

assistant: **Objectives**

Antibodies are destined to neutralize pathogens and can prevent and fight infectious diseases. Over the last years, advances in single B cell cloning resulted in the isolation of highly potent and broad HIV-1 neutralizing antibodies (bNAbs) that have been shown to prevent SHIV infection in non-human primates (NHPs). Recently, we have demonstrated that a combination of bNAbs can suppress HIV-1 replication in humanized mice, reducing viremia to undetectable levels. Moreover, bNAb therapy of SHIV-infected NHPs induced a rapid decline in viremia, followed by a prolonged control due to the long half-life of the antibodies. While these results strongly encourage the clinical evaluation of bNAbs in HIV-1 therapy, it is of critical importance to understand how the therapeutic potential of antibodies can be harnessed in the most effective way. Therefore, we aim to: I.) Identify exceptionally potent HIV-1 neutralizing antibodies that will be a crucial component of immunotherapy. By establishing novel methods for single-cell sorting and high-throughput sequencing we want to identify bNAbs targeting novel epitopes. II.) Prevent HIV-1 escape applying rationally designed treatment strategies targeting conserved functional sites for HIV-1 entry. III.) Evaluate immune markers and function in relation to bNAb administration in humans. Being at the forefront of one of the first clinical trials studying an HIV-1-directed bNAb, we will have the unique opportunity to investigate the interplay of antibody therapy and the host immune system. This proposal aims to strongly advance the field of HIV-1 antibody therapy and therefore enable the introduction of a new therapeutic modality for HIV-1, and will gain insights for antibody-mediated therapy in other infectious diseases.