RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Design and development of novel reagents, tools, and techniques targeting human glutamate carboxypeptidases II and III' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Glutamate carboxypeptidase II (GCPII) is a membrane-bound metallopeptidase with a vast pharmacological potential. Given the intimate involvement of the enzyme in neurotransmission under normal physiological conditions, it is not surprising that GCPII-specific inhibitors are neuroprotective in multiple preclinical models of neurodegeneration. Additionally, the cancer-associated form of GCPII is exploited as a target for immunotherapy/imaging of prostate cancer as well as neovasculature of solid tumors. Despite of its utilization in (pre)clinical settings, the physiological function of GCPII in the latter tissues is unknown and the whole picture is further complicated by the existence of GCPIII, a close GCPII homolog. The main goals of this proposal focus on the identification and development of novel reagents, tools and techniques associated with the GCPII/GCPIII system that may help addressing questions pertaining to the fundamental (patho)physiological roles of GCPII/GCPIII. We will use information from X-ray structures of GCPII/GCPIII complexes to modify and improve characteristics of small-molecule ligands currently used in experimental models of prostate cancer. Secondly, will develop an activity assay based on fluorescence polarization that, in turn, will be exploited for the identification of novel inhibitor scaffolds targeting GCPII/GCPIII. The physicochemical properties of the lead-like compounds will be further optimized to develop isoform (GCPII vs. GCPIII) specific reagents. Such compounds are not available at present and their availability is crucial for dissecting potentially diverse physiological functions of GCPIII and GCPII with implications for GCPII/III associated pathologies. Lastly, we will try to gain insight into non-enzymatic (receptor-like) prope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measuring and modelling the dynamic response of remote mountain lake ecosystems to environmental change. A programme of mountain lake research' (MOLAR) targeting Fourth Framework.

assistant: **Abstract**

Because of their sensitivity remote mountain lakes are not only vulnerable to environmental change they are also excellent sensors of change, and their high quality sediment records can be used to infer the speed, direction and biological impact of changing air quality and climate. This proposal builds on the success of the EU funded AL:PE projects (Acidification of Remote Mountain Lakes: Palaeolimnology and Ecology; Remote Mountain Lakes as Indicators of Air Pollution and Climate Change), which represented the first comprehensive study of remote mountain lakes at a European level and assessed the status of remote mountain lakes throughout Europe on the basis of sediment core records and chemical and biological surveys. MOLAR focuses on detailed studies of a smaller number of key sites located across the climate and deposition gradients of Europe, from the arctic to the Mediterranean and from Scotland to the High Tatra Mountains, to provide high resolution data on their temporal dynamics that can then be used to develop and calibrate predictive models. The project has four overall objectives, each corresponding to a major work package described in the proposal: - to measure and model the dynamic responses of remote mountain lake ecosystemsto acid (sulphur plus nitrogen) deposition; - to quantify and model pollutant (trace metals, trace organics) fluxes andpathways in remote mountain lakes and their uptake by fish; - to measure and model the temporal responses of remote mountain lake ecosystemto climate variability on seasonal, inter-annual and decadal time-scales. - to continue the development of a high quality environmental database onremote mountain lake ecosystems in Europe and to disseminate results widelyto enhance public awareness, environmental education and envi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The next generation epigenetic medicine for inflammation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Epigenetic mechanisms allow cells to adjust gene expression in response to environmental cues. Increased understanding of this area has led to excitement about the potential of applying epigenetic regulation to drug discovery. EPIMAC aims to pursue the potential of epigenetics as a novel and innovative therapeutic modality for immuno-inflammatory diseases, in particular Inflammatory Bowel Disease (IBD). IBD is a severe and disabling chronic inflammation of the gastrointestinal tract affecting millions of people worldwide. Current treatment strategies are not successful because the precise etiology unclear. It is increasingly clear that deregulated epigenetic processes are associated with the aberrant inflammatory response seen in IBD. Recent reports suggest that inhibitors of epigenetic modifications developed by GlaxoSmithKline (GSK), such as histone deacetylase (HDAC) inhibitors, bear potential in treating inflammatory states (Nicodeme et al, Nature 2010; Kruidenier et al, Nature 2012). The EPIMAC consortium has the ambition to educate a group of next-generation scientists that master genetics, epigenetics, target discovery, pharmacology, preclinical validation and regulatory issues, and at the same time have a good understanding of clinical implementations of the drug pipeline of our pharmaceutical partner GSK. GSK is one of the world's leading research-based pharmaceutical and healthcare companies that aims to team up with academic partners in EPIMAC through its dedicated discovery performance unit named EpiNova in conjunction with 2  immuno-pharmacology units. An SME specializing in epigenetic compound targeting to inflammatory cells, Chroma Therapeutics, will contribute technology to EPIMAC. EPIMAC will educate and train these scientists by providing them with a v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Emergent Active Mechanical Behaviour of the Actomyosin Cell Cortex'.

assistant: **Concept**

The cell cortex is a highly dynamic layer of crosslinked actin filaments and myosin molecular motors beneath the cell membrane. It plays a central role in large scale rearrangements that occur inside cells.  Many molecular mechanisms contribute to cortex structure and dynamics. However, cell scale physical properties of the cortex are difficult to grasp. This is problematic because for large scale rearrangements inside a cell, such as coherent flow of the cell cortex, it is the cell scale emergent properties that are important for the realization of such events. I will investigate how the actomyosin cytoskeleton behaves at a coarse grained and cellular scale, and will study how this emergent active behaviour is influenced by molecular mechanisms. We will study the cell cortex in the one cell stage C. elegans embryo, which undergoes large scale cortical flow during polarization and cytokinesis. We will combine theory and experiment. We will characterize cortex structure and dynamics with biophysical techniques such as cortical laser ablation and quantitative photobleaching experiments. We will develop and employ novel theoretical approaches to describe the cell scale mechanical behaviour in terms of an active complex fluid. We will utilize genetic approaches to understand how these emergent mechanical properties are influenced by molecular activities. A central goal is to arrive at a coarse grained description of the cortex that can predict future dynamic behaviour from the past structure, which is conceptually similar to how weather forecasting is accomplished. To date, systematic approaches to link molecular scale physical mechanisms to those on cellular scales are missing. This work will open new opportunities for cell biological and cell biophysical research, by prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'High resolution monochrome monitor, 3000 x 3000 pixels, for diagnostic use'.

assistant: **Innovation**

With the introduction on the market of large solid sate detectors (43 x 43 cm.) of producing high resolution digital X ray images (3000 x 3000 x 14 bits), tr X ray film is no longer needed. The existing monochrome diagnostic monitors, however, can only let us view image a maximum resolution of 2000 x 2000 x 8 bits and thus a loss of data. As a result, we now need high resolution monochrome monitors (3000 x 3000 pixels) for more accurate diagnosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chitosan activates resistance against pathogens after exposure production of chitosans from shrimp shells for applications in plant disease protection' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

A consortium of 5 scientific, 1 governmental, and 3 commercial partners has convened to develop and exploit the economic and ecological potential of the abundant biological raw material chitin isolated from waste shrimp shells that will be up-graded into chemically and biologically well defined chit sans. This biocompatible, biodegradable, non-allergenic, non-toxic chit sans will be tested for their ability to protect economically important crop plants from disease. The up-grading of bulk chatoyant into pure, high added value speciality chit sans for consumer-safe, environment-friendly, cost-effective plant protection will add value and improve whole crop utilisation for the shrimp fisheries, improve sustainability in agriculture, and improve the quality of life by supplying healthier food to EU citizens. The creation of new working relationships between fisheries and agro-industries will lead to new knowledge-based companies increasing employment opportunities in the EU, by opening the agro-industry and, foreseeable, the medical market for high quality chit sans, so that the EU may become world leader in this growing biotechnology market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The lexical semantics of lexical categories'.

assistant: **Innovation**

The distinction between the major lexical categories of noun, verb and adjective figures into myriad linguistic generalizations and has been a center of gravity in the study of language since antiquity. Notwithstanding their importance, lexical categories are poorly understood (see e.g., Baker & Croft 2017). Outstanding is whether there are generalizations about the meanings words in the major categories have. Many have claimed there are, and proposed theories linking meaning and category, in a one to one fashion. Such theories have been criticized, however, in light of clear counterexamples, and consequently the search for a universal link between meaning and category is perceived by many to have been unsuccessful (see von Fintel & Matthewson 2008). This project recasts the search for a link, in the spirit of recent work (Francez & Koontz-Garboden 2017: Chapter 5), not as one for a one-to-one mapping, but for constraints on meaning induced by category. The project targets a domain where the set of relevant meanings is small, but where there is variation in category: property concept sentences—sentences like (1) He is very clever, whose main predicate is an adjective or, (2) akwai shi da waayoo `He is very clever (lit: He exists with cleverness; Hausa; Newman 2000:179)', whose main predicate is not an adjective, but is translated by a sentence whose main predicate is an adjective in languages with a large class of them. Although (1) and (2) have the same meaning, their component parts do not. Recent work shows that the words in property concept sentences that introduce the descriptive content (clever in (1), waayoo (2))--property concept words--vary in meaning, not just in category (Dixon 1982). With three postdocs, this project draws on a 200 language typological surve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pan-European Network of Customs Practitioners' (PEN-CP) targeting Horizon 2020.

assistant: **Abstract**

PEN-CP, the Pan-European Network of Customs Practitioners – EU Horizon 2020 funded Customs security practitioner project – acts as a European Customs innovation boosting network, powered by an innovation-centric online platform, and tailored innovation intermediary services. Since the start of the project (Sep.2018), the project consortium includes the following 13 administrations as full partners (9 EU and 4 non-EU): ALB, AUT, BEL, EST, GBR, HUN, IRL, LTU, LVA, NLD, MKD, NOR & SVK. PEN-CP focuses on accelerating innovation efforts across three core Customs technical areas: Data and risk management; Detection technologies; and Laboratory equipment. We have a broad variety of innovation and knowledge instruments in use, including Technology grants, Challenge competitions, Innovation awards, Annual studies and Expert reports. Across our activities, we aim to connect innovation-spirited Customs officers, helping them to ‘find friends in Customs innovation’. The vision is to become a permanent Customs innovation boosting network, helping to accelerate both incremental and radical innovations, for the benefit of Customs administrations in Europe and beyond.


**Keywords:** Customs security, co-development, innovation, organised crime, supply chain security
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'To critically evaluate vegetable acceptability through individual and environmental characteristics across the lifespan in institutional food service' (2007-2013).

assistant: **Innovation**

Adequate vegetable consumption is fundamental to a healthy balanced diet, however, EU compliance with dietary guidelines is poor and further research is required to overcome consumption barriers. The aim of VeggiEAT is to develop an EU platform for predictive modelling of processed vegetable intake that takes into account individual characteristics (acceptability, intake level, age groups) as well as environmental cues (choice architecture and institutional setting). This aim will be achieved through the development of consumer-oriented products (sensory analysis); the development of recipes for use by food providers (restaurants, canteens, etc.); and the benchmarking of choice architecture facilitating the consumption of vegetables. Results will be gathered and modelled to provide strategic intelligence for decision-making (by Industry) and for policy purposes (by the EU); further, this translational research will be disseminated both at scientific and consumer levels. The application of these results will contribute to operational benefits for European vegetable manufacturers (growers, processors, retailers etc), while adding to the body of knowledge regarding consumer behaviour and preferences towards vegetables. The conceptual model will translate the latest academic research results into a greater understanding of factors determining vegetable consumption while informing a commercially viable vegetable product and therefore strengthen European competitiveness. This Industry-Academia-SME collaboration will invigorate the vegetable sector in Europe while addressing in a constructive way the EU objectives of healthier eating at population level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'STable high-capacity lithium-Air Batteries with Long  cycle life for Electric cars' (STABLE), addressing dissemination and exploitation.

assistant: **Impact**

Electric car is considered as the most promising technical solution for automotive industries in 21st century since the use of electric energy not only slows down the petrol consumption but also contribute to reduce the CO2 emission and toxic air pollutants.Due to its good performance, Li-ion battery is generally studied to meet the above demands. However, it is still not satisfactory for long distance use because of its limited energy density. Therefore Li-air batteries have attracted worldwide attentions as an ideal alternative, because their outstanding energy density is extremely high compared to other rechargeable batteries.In this project, a multidisciplinary work team in materials synthesis and characterization, cell assembly and test will cooperate to perform a joint research to deliver a Li-air battery cell for EVs with high capacity and long cycle life in laboratory scale.This project focuses on innovations of battery anode, cathode, electrolyte materials and technologies, as well as assembly of batteries cells which are crucial on battery performance, cost and environmental impact. Improvement of lifetime and cyclability of Li-air batteries through finding highly active bifunctional catalysts to effectively regenerate batteries, protecting the Li anode from dendrites formation using suitable membranes and obtaining stable electrolyte with additives to render solubility of Li2O2 that blogs on cathode will be studied.Activities will focus especially on 1) optimization of cathode structures; 2) the selection of active catalysts and dehydration membranes; 3) modification of anode structure with necessary protecting layers, additives or surfactants; 4)modification of electrolyte properties. The final aim is to obtain Li-air battery cells with specific capacity of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impact of whole-genome duplications on the genetic and genomic architecture of adaptation' (POLYGARCH).

assistant: **Concept**

Whole-genome duplication (WGD) is arguably the most severe mutation that an organism may undergo. As such, WGDs are often fatal, but the resulting polyploids that survive the initial shock to cellular processes may ultimately thrive. Whether conditions created by WGDs are beneficial or detrimental to adaptation is a long-standing question in evolutionary biology, with important implications for domestication and crop breeding. A key determinant of evolutionary responses is the genetic and genomic architecture of adaptive traits: i.e. the control of phenotypes by one or many loci, the interactions between alleles, positions of loci in relation to genomic features, and structural arrangements. By combining cutting-edge evolutionary modelling, novel machine-learning tools, and multi-species genomic data from short- and long-read sequencing, I propose to determine how WGDs alter the genetic and genomic architecture of local adaptation. Such knowledge will advance our understanding of the evolutionary success of polyploids, provide insights into factors influencing the current distribution of polypoid populations and species, as well as yield important information for predicting how polyploids respond to environmental change.


**Keywords:** polyploidy, local adaptation, genetic architecture, structural variation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Diesel-low emission levels by engine modelling'.

assistant: **Objectives**

Numerical models for the prediction of diesel engine spray development; combustion and emission formation will be developed. A wide range of engine operation conditions will be covered: effects caused by injection rate history, heat transfer and by exhaust gas re-circulation (EGR) will all be taken into account. Both passenger car and truck engines will be studied. Sub-models will be coded by model developers with a well-defined interface to basic CFD codes and will, whenever possible, work independently of a particular CFD code. Validation of the models will be done in carefully designed experiments in high-pressure diesel combustion chambers as well as in well-defined engine experiments. The work to implement and supply models in engine CFD codes will be out by participating automotive companies. The CFD code will be the one presently used for engine combustion applications within the company.