RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Climate adaptation in Arabidopsis thaliana through evolution of transcription regulation' (TxnEvoClim).

assistant: **Concept**

Differences in gene expression play a key role in generating the phenotypic variability needed for adaptation. During evolution, the coding sequence of genes evolves on average much slower than their expression patterns, thus transcriptional regulation can be especially important for rapid adaptation to a new environment. Climate is a major factor for plant adaptation, and both the dispersal of a plant from its native origin as well as climate change will often lower its fitness. Thus, understanding how gene expression patterns are modified to facilitate life in adverse climates would shed light on the trade-offs limiting adaptation. Studying how evolution has shaped plant transcriptomes so that these plants can grow in different ecological niches and their potential to adapt to a changing climate requires a large base of natural variability information. This has recently been accumulated for Arabidopsis thaliana, a model for genetic and evolutionary studies. In the proposed project I will use genomic and transcriptomic data from the A. thaliana 1001 Genomes Project, new measurements of gene expression under water deprivation, as well as newly available data on gene-regulation and field fitness, to define how gene expression is shaped by climate and the genetic potential to adapt to new environments. I will address the following: (1) In natural populations, how do gene expression patterns of individuals correspond to the particular adapted climates? (2) What is the genetic basis for the transcript differences and how is it reflected in modifications to the transcriptional network? (3) Can knowledge of climate-transcript variation relationships be predictive of individual strains more likely to survive in a new climate? As climate is changing due to global warming, the u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Calibration of test systems for measuring the thermal output of radiators and convectors following EN 442' under Fourth Framework.

assistant: **Concept**

The thermal output is an exponential function (characteristic equation) of the temperature difference between the ambient air and its external surfaces and of other relevant parameters. The combination of all the heat transfer phenomena, the varying heat flux and the different temperatures at each point of the external surface makes the computation of the characteristic equation of a radiator very difficult, too expensive and of insufficient accuracy. Physical testing of a sample product is therefore the only practical method to determine the characteristic equation with adequate accuracy. Testing requires a great number of measurements that have to be taken under steady state and in well defined boundary conditions. This is difficult to achieve and small variations influence significantly the reproducibility of test results. However, small differences in stated output have large consequences on the economic value of the products since the thermal output value is of great importance for the market. In Europe, the discrepancy between the results of the tests of the thermal output is approx. 10% which is unacceptably large. The greatest values acceptable for the customers and for the trade is +/- 1% ( total spread 2%).The project has therefore two objectives:- to establish the TRACEABILITY for the thermal output measurements of radiators and convectors in conformity with EN 45001; achieving the repeatability of 1% and the reproducibility of 2% fixed by the standard EN 442-2,- to establish a draft accreditation procedure to be used by accrediting European Bodies in conformity with the standard EN 442.The contract started on 1 July 1997 with work on a provisional draft for the accreditation of Laboratories and on the instrumentation to be installed by each laboratory. Devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Human Capital, Public Policies, and Income Inequality Within and Across Countries'.

assistant: **Concept**

One of the most important challenges in economic sciences is to explain the observed large differences in the wealth of nations. Although, total factor productivity is at the core of income inequality across countries. One of the main difficulties is that there are no measures of quality of education and productivity across countries. To assess the sources of cross-country income inequality, economists need to assume away cross-country differences in the quality of schooling and to measure productivity as a residual. It would be unfeasible to do a standard variance decomposition analysis as economic theory implies that quality of education and total factor productivity are likely to be jointly determined. Moreover, without a tight measurement of human capital and its effects on the economy, no sound analyses can be carried out of the impact of public educational policies. The proposal aims too, to develop a structural model of human capital investments decisions and use this model for two socio-economic studies: 1. International quantitative assessment of total factor productivity and human capital in accounting for the per capita income inequalities observed; 2. Quantitative cross-country investigation of public policies on the distribution of education and income, and intergenerational mobility The project proposes to use the new theoretical framework to evaluate the aggregate and distributive effects of some recent proposals for reforming taxation and education institutions in O.E.C.D. countries. The research will make easier to understand the poverty of the nations and provide European policy makers with valuable insights for reducing the extent of poverty. This proposal will help the researcher, Andrés Erosa, to reintegrate among the European academics and will pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Electric natural entryways' (ENTER), addressing dissemination and exploitation.

assistant: **Impact**

The reach of biological electron transport (ET) increased from nm to cm with the discovery of cable bacteria that do ET via highly conductive fibres along their filaments. Their extremely long distance ET electrically connects 1000s of cells and influences redox cycling. Other bacteria interact with this electric highway via interspecies ET. A visual version: flocking, where aerobes use cables to breathe oxygen in its absence. Flockers dump electrons on intermediates, electron shuttles, which cables recycle. Since their discovery, cable bacteria sparked interest for green, biodegradable electronics. Flocking suggests that we can access the electric fibre without damaging it. Cables must have a natural electric entryway, to upload electrons from shuttles onto the fibres. ENTER aims to map this.We combine Prof Meysman's expertise on cable bacteria fibres with mine on flocker-cable bacteria interactions to: 1) Identify the electron shuttle by extensive electrochemical characterization of flockers (isolated in my PhD), map their ability to generate electricity, and find shuttle production potential in the genomes. 2) Advance models to find entryway protein sequences in closed cable bacteria genomes (from the host). 3) Localize the entryways on the filament and activate them using correlative light and electron microscopy with labelled shuttles and Raman microscopy.ENTER will provide new insights into the functioning of electric ecosystems and electric microbes. It will offer novel perspectives on redox and electron flow in natural systems. For example, oxygen breathing way beyond its presence will affect CO2 burying and sequestration in the seafloor. ENTERs impact, not limited to natural systems, will also inspire new insights for engineered systems (microbial fuel cells, c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of photonic multi-sensing systems based on molecular-gates biorecognition and plasmonic sensors' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the current world, there is a clear need of advanced multi-sensing systems capable of providing fast and quantitative detection of a huge range of hazards which could affect human health in our daily life. Sectors such as healthcare, food safety or environment control, among others, will require these tools to take fast and effective actions and prevent potential crisis impact. In this context, PHOTONGATE aims to develop an adaptable diagnostics solution, comprising Photonic cartridges and read-out platform, which allow to quantify multiple analytes of the same or different nature (biomolecules, chemicals, metals, bacteria, etc.) in a single test with levels of sensitivity and selectivity at/or over those offered by current commercial solutions. PHOTONGATE technology relies on a new sensing concept which combines two core technologies:  a bio-chemical technology (molecular gates) which will confer the specificity and increased sensitivity to the system, and, on the other hand, a photonic technology (light interaction with Local Surface Plasmonic Resonance (LSPR) structures) working as transducers and allowing the quantification. PHOTONGATE consortium has been specifically designed for maximizing the project success since all the actors of the value chain are enrolled. In addition, the development and integration of the different PHOTONGATE components have been designed searching for the European autonomy by using European research, knowledge and fabrication networks as well as favoring European providers. PHOTONGATE goals will involve a significant progress beyond the State-of-the-Art in multi-sensing systems achieving faster and high sensitivity detection of multiples targets. A final validation of PHOTONGATE technology in relevant scenarios for health and food safe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Parental Employment and Child Investments' (PEACH) under Horizon 2020.

assistant: **Objectives**

Flexible working practices can help parents to maintain household income whilst not compromising time spent with their children. Such working arrangements also help parents maintain a balance between work and family life  leading to increased productivity and improved well-being. However, there are costs involved, such as lower wages, job security, opportunities for career advancement, and training.  In addition, the leisure time of parents is likely to fall as parents spend an increasing proportion of their time on domestic and work activities.Applying microeconometric methods, the project PEACH will analyse the causal effect of flexible and non-standard working practices on both child and parental outcomes by analysing two specific policies which allow individuals to relax the full-time and the standard hours commitment to their job. 1. The German Part-time and Fixed Term Employment Law 2000 2. The UK Right to Request and Duty to Consider Flexible WorkingSpecifically, PEACH will pursue the following research objectives to explore the flexible working practices in the UK and GermanyR1: Examine the uptake of flexible working practices on mother and father employment, R2: Examine the effect of flexible working practices on the parents’ (i) total hours of domestic and labour market activities, (ii) long-run career, and (iii) mental health.R3: Examine the effect of flexible working practices on child cognitive and health outcomesR4: Create a network and Disseminate results to a broader audience.PEACH involves mobility for the researcher, with a secondment at DIW, Berlin, Germany. This will enhance Sarah's network and establish Sarah as an expert of the German data. PEACH involves training, including microeconometric methods, labour economics and data analysis from experts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissection of the Interactome and the Regulatory Network of the Dual-Function Transcription Factor Ying Yang 1, a Master Regulator of Plant Stress Responses and Development' (DIRE-YY1) under Horizon Europe.

assistant: **Objectives**

Climate change and increasing exposure to environmental stress make adaptation and defence responses to one of the most significant factors for crop yield and quality. At molecular level, stress-inducible master regulators and key transcription factors translate the stress-signalling into defence and developmental responses at the level of chromatin and gene expression. The dual function transcription factor YIN YANG 1 (YY1) is evolutionary conserved between animal and plant kingdom. In Arabidopsis, the ABA-inducible YY1 is a negative regulator and key component of ABA responses, contributes to the plant resistance to fungal infection and UV-B radiation, and controls flowering time. Some stress related functions of YY1 are conserved between Arabidopsis and Populus tree. Published and the preliminary data indicate that the stress-inducible YY1 in Arabidopsis is a hub that converts stress-signals into defence and developmental responses through interaction with transcription and epigenetic factors controlling common target genes. However, neither the protein-protein interactome nor the direct target genes of YY1 were intensively investigated. On the level of protein-protein interactome of YY1, the comparison of published YY1-Flag IP-MS data with the preliminary Y2H screen data did not find any overlap, although both groups of YY1 interaction candidates contained transcription and epigenetic regulators. These findings and theoretical considerations suggest that large parts of the 'dark interactome' of YY1 wait still to be discovered. Regarding the direct target genes, the proposed ChIP-Seq approaches are the first attempt to study YY1-DNA binding at a global scale. The anticipated results will have a deep impact on understanding of the complex protein-protein interactome o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety of traditional fermented sausages : research on protective cultures and bacteriocins' (SAFETYSAUSAGE) under Fifth Framework.

assistant: **Objectives**

The development of protective cultures, having the ability to optimise the fermentation and ripening processes and also to improve the safety and traditional 'sensory type', is the main aim of the project. To achieve this is needed to: -isolate and identify the predominant 'wild' strains of the traditional fermented sausages, - select strains according to their safety, sensory and technological properties, - validate with experimental and industrial trials the selected strains as well as the selected bacteriocins (in combination with commercial starters), as possible protective compounds. The expected results are the collection of high quality bacteriocinogenic lactic acid bacteria (or their bacteriocins in purified form) with the desired technological properties and active against pathogenic bacteria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'CENTRE OF EXCELLENCE IN COMPUTATIONAL FLUID DYNAMICS'.

assistant: **Concept**

The mission of the Centre for CFD is to conduct academic research in CFD in engineering and environment and computing practice, and to bring the emergent, cutting-edge simulation capability to focus in assisting industry to do a better job of environmental , engineering and medical design optimisation. All the Marie Curie Fellows, MSc and PhD students and research fellows in the Centre for CFD, plus participating industrial scientists and engineers, conduct leading-edge research into the fundamentals and app lications of CFD in this world-class environment and thus promote rapid conversion of theory into practice. A simulation of computer-based software systems, using high performance computing has the potential to supplant the concept and practice of isolated commercial code installations, with their use restrictions, costs, upkeep and legacy numerical methods. As a broker of new and innovative technologies, the CFD Centre¿s academic members perform technology surveys and reviews. One-on-one technical assistan ce ensures the successful transition of new technologies to the public and private sectors. The CFD Centre also conducts, hosts and supports training, technical conferences and workshops designed to transfer new and innovative ideas in CFD engineering and environment, and high performance computing concepts and applications across industry, including small, medium and large sized enterprises. Members of the CFD Centre also furnish technical assistance to the shared resource centre staff to ensure the succes sful transition of new technologies to operating and programming environments. All of the Marie Curie Fellows attached to the CFD Centre will partake in this innovative research and most of them will be involved in assisting in the transfer of knowledge to ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Glomerulonephritis and Focal Segmental Glomerulosclerosis as a Model to Investigate the Link between Inflammation and Kidney Disease: From Basic Mechanisms to Clinical Application' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Rapidly progressive glomerulonephritis (RPGN) and focal and segmental glomerulosclerosis (FSGS) are severe kidney diseases responsible for irreversible renal failure, which is a major risk factor for mortality. Despite the aggressiveness of immunosuppressive protocols applied, treatments against RPGN have limited effectiveness. Similarly, there is no specific treatment for FSGS. We built this research project on novel identification of molecular pathways and markers of pathogenic glomerular epithelial cells (GEC). Although major roles of endothelial activation with immune-mediated insult and imbalance between coagulation and fibrinolysis have been demonstrated, our findings reinforce this paradigm that “activation” of resident glomerular cells play a key role in disease and extend the concept by examining interactions between surrounding cellular systems. We hypothesize that abnormal activation of G-protein coupled receptors (GPCRs) and EGFR may synergize to switch the phenotype of GECs from healthy to pathological. We propose that coagulation and dysfunction of the capillary barrier, may provide GPCR ligands to receptors present in target cells such as GECs. GPCRs, themselves implicated in GN, are known to transactivate the EGFR. The EGFR has the potential to amplify actions of GPCRs in GECs, leading to cytoskeletal rearrangement, and cell death. We hypothesise that interactions between “switched GECs” and T cells are essential for the perpetuation of the immuno-inflammatory response in such glomerular diseases, after the potentially groundbreaking discovery that lymphocytes display functional EGFR, sensitive to ligands produced by pathological GECs. Finally, we will harness this knowledge for a better identification of patients at risk of glomerular demolition. Our pr