RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Selective Electrochemical Nucleophilic Fluorination' (SENF) under Horizon 2020.

assistant: **Objectives**

The incorporation of fluorine into organic compounds is extremely important for designing molecules with specific function. Fluorine is primed for improving the pharmacokinetic properties of drugs and agrochemicals, and is crucial for the life-changing imaging technique, Positron Emission Tomography (PET). Thus, selective fluorination is an area of significant interest in organic synthesis.This research programme will develop a concept that promises to revolutionise fluorination chemistry. While nucleophilic fluoride (F-) sources are inexpensive and readily available, they have unfavourable reactivity compared to electrophilic fluorine sources (F+), which are typically expensive, wasteful and not suited to either large scale synthesis or PET. By transmuting F- into F+, we can get the best of both worlds! We will develop a concept based on umpolung (polarity reversal) to invent a number of novel synthetic methodologies or to expand useful reactions into new chemical space. The overall vision is to create new pathways to new bioactive molecules that are either more potent, have improved pharmacokinetics, or can be new radiochemical tracers.Our strategy relies on the combination of catalysis and electrochemical oxidation to perform this thermodynamically demanding task. The use of electrochemistry is essential for this strategy, because it is necessary to be able to dial-in any oxidising potential with high control. New organo- and organometallic catalysts, heterogeneous electrocatalysts and fluoride sources will be developed as part of the studies, which will be of value to the fields of fluorination, homogeneous catalysis, synthesis and energy research. Medicinal, process and radio chemists will all benefit as their toolbox of methods will expand, thereby facilitating th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Multimedia Services Integration Chain in Advanced Networks'.

assistant: **Concept**

MUSICIAN's goal is to develop and launch attractive multimedia services which effectively combine the potential of new technologies with the wealth of material created for broadcasting purposes. It will address all aspects of the multimedia service creation and delivery chain starting with contents creation and finishing with the evaluation of the services by end-users. It will not look at the different entities in isolation but consider the interfaces between them in order to allow for a smooth transition process.During the first four months of MUSICIAN's existence the main effort has been spent on the content and service parts of the multimedia chain. The two content partners WDR and ORF developed concepts for attractive multimedia services. Also, a first service provisioning approach had been defined. From a technology perspective the project concentrated on the specification of the network architecture including CATV management. In addition, requirements were defined for the end-user devices to be utilised for delivering content to customers.MUSICIAN is expected to provide results in all areas of the multimedia services integration chain (content creation, service creation, service provisioning, network provision and customer acceptance). However, the main focus is the evaluation of the overall approach and not so much the individual components.Expected impactMUSICIAN is a concrete step towards the realisation of the European Information Society. It will provide residential users in a specific Tele-region" with easy access to multimedia service offers an will therefore contribute to an improved quality of life. It will add to the overall attractiveness of the region in terms of its economic competitiveness, i.e. advanced network infrastructure, know-how acquisition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Leveraging room temperature diamond quantum dynamics to enable safe, first-of-its-kind, multimodal cardiac imaging' (MetaboliQs), addressing dissemination and exploitation.

assistant: **Impact**

Cardiovascular Diseases (CVDs) are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. Despite emerging diagnostics tools and therapeutics, several areas of significant unmet need remain unaddressed among CVD patients. The ability to personalize cardiovascular medical care and improve outcomes, will require characterization of disease processes at a molecular level. The current state-of-the-art, e.g., Positron emission tomography (PET), does not provide detailed information about the chemical state of the tissue at a molecular level, therefore it remains difficult to accurately diagnose and confidently select appropriate therapy in many circumstances.  The MetaboliQs project brings together two areas of European excellence - diamond-based quantum sensing and medical imaging. We will translate a newly developed hyperpolarization method for magnetic resonance imaging (MRI) based on the quantum dynamics of nitrogen-vacancy (NV) centers. This breakthrough quantum technology will enable previously unachievable, highly sensitive quantification of metabolic activity, paving the way for precision diagnostics and better personalized treatment of cardiovascular and other metabolic diseases.  For realizing and eventually commercializing the technology, MetaboliQs brings together a world-class multidisciplinary consortium with end to end expertise - leading diamond quantum technology research institutes (Fraunhofer IAF - quantum-grade diamond growth and fabrication, HUJI - quantum sensing) and innovative companies (Element 6 - worldwide leader in synthetic diamonds, NVision - inventor of diamond-based polarization), as well as two expert users of hyperpolarized and cardiovascular MRI (TUM, ETH Zurich - first in continental Europe to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Testing Gauge String Duality'.

assistant: **Innovation**

The goal of this project is to invent new mathematical and physical methods of integrable systems and use them to compute the non-local observables of gauge theory and string theory exactly with respect to the coupling constant. It is believed that a special type of gauge theory and string theory are two equivalent descriptions of the same physical phenomena. This idea is called the Gauge/String Duality or AdS/CFT correspondence. This research thereby tests the AdS/CFT correspondence via the exact computation of non-local objects based on integrability methods.The integrability method called the Thermodynamic Bethe Ansatz (TBA) equations is the basis of our method. This set of equations is expected to give the spectrum of the conformal dimension of local operators in N=4 supersymmetric Yang-Mills theory, and the energy of closed string states on the AdS_5 x S^5 space-time, for any operators/states and at any value of the coupling constant. This project aims at generalizing this powerful formulation, and developing novel methods to solve nonlinear integral equations of TBA-type in analytic and numerical manners.The theory of integrable systems has rich mathematical structure, and is one of the major research fields in the modern mathematical physics. The integrable systems have a long history of its own since the discovery of quantum mechanics, and their exact solutions have provided important physical insights with the researchers of low-dimensional lattice models, quantum field theories, string theory and the AdS/CFT correspondence.The applicant will undertake the research at the Mathematical Institute in Oxford under the supervision of Prof. Luis-Fernando Alday. The applicant will also participate in the Oxford String Theory Group, which is one of the largest string t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Researchers’ Night in Greece', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The need to increase public awareness on how research is performed and is beneficial for the society, has been the driving force for this project. The main objective of the EURORES is to bring closer researchers to the Greek society, increase public recognition and strengthen their role in the research and technological development of Greece. In parallel, EURORES aims to stimulate young people’s interest towards science and make research an attractive career. To this direction, on 26.9.2008, three Researchers’ Night Events will be organized in three big cities of Greece, Athens, Larissa and Alexandroupolis and they will be devoted to X-rays application in archaeology, drug discovery, and health (Athens), Biotechnology in everyday life (Larissa), and Molecules of Life (Alexandroupolis). A host of activities including round table discussions, interaction with the audience, demonstrations, displays, a wide variety of experiments for hands-on experience, and photo competitions will help to attract more than 6000 visitors of all ages to advance the public understanding, accessibility and accountability of science, along with benefits that the research should bring to society in the future from potential cures and treatments of diseases to the impact of biotechnology on society. To achieve this, an awareness campaign targeting mass media will be launched, a website, and a European corner will be installed, amongst others. The integration of these activities within EURORES will significantly enhance the position of the European researcher in society in the years to come.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Re-engineering symmetry breaking in development and evolution' (RESYDE), addressing dissemination and exploitation.

assistant: **Impact**

Scientists have long sought to understand how complex multicellular organisms generate their final form. Yet despite considerable progress, demonstrating predictive knowledge sufficient to re-engineer development according to design, remains a grand challenge. Addressing this challenge is not only fundamentally important, but also critical to the future of regenerative medicine and agriculture. Development depends on coordinated symmetry breaking events resulting from diverse mechanisms, ranging from the asymmetric localisation of molecules and stochastic processes within cells to the formation of morphogen gradients across a tissue. A mechanistic understanding of complex patterning processes therefore requires gaining knowledge on the molecular basis of multiple types of symmetry breaking events occurring at different scales. RESYDE will address this challenge by integrating information from diverse approaches into a virtual, dynamic cellular template. Predictive modelling will then be used to explain symmetry breaking at different scales sufficient to re-engineer the system by design. We will use the Arabidopsis flower as a model system and apply an interdisciplinary approach that utilises fine-scale perturbation techniques together with in vivo live-imaging of key regulators along with spatially mapped multi omics data, hormonal gradients and tissue mechanics to monitor responses at multiple scales. To leverage these data we will establish a 4D virtual cell template together with multiscale models to generate and simulate hypotheses in silico on the precise molecular origins of symmetry breaking events within the flower. We will apply our knowledge using a re-engineering approach to alter multiple floral symmetry breaking processes to better understand evolutionary f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'On the ModElling of micro-robots in the Gut: a non-smooth dynamics Approach' to be submitted under Horizon 2020.

assistant: **Abstract**

Detection of bowel cancer is currently performed by visual inspection of the colonic mucosa during endoscopy, which is less reliable for small-sized lesions that are not easily visualised. If they are not detected and removed at an early stage, there is a chance that they may become cancerous. This project seeks to develop a new mathematical tool for analysing the sensing capability of micro-robots to aid the detection of hard-to-visualise bowel lesions. Micro-robots experiencing vibrations, frictions, and impacts, known as non-smooth dynamical systems, exhibit a rich variety of different long-term behaviours co-existing for a given set of parameters, which is referred to as multi-stability or co-existing attractors. When the robot moves in the colon and encounters a lesion, some particular attractor may dominate its dynamics, while the other co-existing attractors could fade away due to the tissue’s mechanical properties associated with different stages of malignant transformation. This significant change in multi-stability can be utilised to distinguish between healthy and abnormal tissues. The fellow proposes to use for the first time robot’s multi-stability through the development of state-of-the-art numerical techniques to analyse such robot-lesion correlation, and produce a suite of computational analysis and advanced control methods for cancer detection and staging. In the long term, this work will initiate a new modality for bowel cancer screening, delivering an efficient minimally invasive procedure for patients. The unique research approach of this fellowship, a joint effort of numerical and experimental studies, will be hosted by Dr Yang Liu from the University of Exeter with the secondment supervisor, Prof. Bradley Nelson from ETH Zurich, and the consulting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Redox cycling of iron and manganese - the role of biosorption', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Bacteria have a high capacity to bind metal ions at their cell surface. Sorption of metal ions onto bacterial cell walls forms the basis of several microbially based purification techniques. Sorption onto bacterial surfaces is also relevant for the mobility of nutrients and metals in subsurface environments. The proposed project is dedicated to the sorption of Fe(II) and Mn(II) onto the cell wall of two Gram-negative bacteria with metal reducing capability, Shewanella putrefaciens and Geobacter metallireduc ens. In the proposed project we will address the effect of Fe(II) and Mn(II) sorption on the vitality of the bacteria and, in particular, their dissimilatory iron and manganese reduction activity. We will investigate whether changes in the cell wall composition, due to an adaptation of the bacteria, or due to changes in the metabolic status of the bacteria, influence the biosorption of Fe(II) and Mn(II). Finally, we will determine how biosorption of Fe(II) and Mn(II) influences the oxidation kinetics of the se metals.The major goals of the proposed project are to:1) investigate the sorption of Fe(II) and Mn(II) onto bacterial cell walls under variable environmental conditions,2) unravel the sorption mechanisms and develop a conceptual model describing metal sorption3) determine the variability of Fe(II) and Mn (II) sorption depending on changes in cell wall characteristics and other active responses of the bacteria4) evaluate the implications of Fe(II) and Mn (II) sorption on the redox cycling of these elements , in particular, with respect to the oxidation of Fe (II) and Mn (II) and the rates of dissimilatory reduction of the corresponding oxyhydroxides.The proposed project will significantly improve our understanding of the interrelation between microbiological act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of comprehensive and user-friendly bioinformatics tools to study protein structures and interactions in mass spectrometry-based chemical cross-linking'.

assistant: **Innovation**

Mass spectrometry-based chemical cross-linking (XL-MS) is an emerging field to study protein structures, conformations and interactions. Despite its great potential, the data analysis part hinders its widespread applications for a variety of reasons. First, an arduous manual validation is still used in many laboratories. Second, most of the available bioinformatics tools are limited to conventional cross-linkers and not the new type of cross-linkers: MS-cleavable cross-linkers which are key to study protein interactions. Besides, almost every tool has been developed for identification but not quantification, which provides valuable information for changes in protein conformations. Above all, these tools are not user-friendly and requires an assistance of an expert bioinformatician for analysis. I therefore plan to develop fully-automated, comprehensive, user-friendly and free bioinformatics tools for XL-MS studies. This will be a part of one of the most commonly used proteomics software, MaxQuant, developed in the Cox group. MaxQuant software has already well-established preprocessing steps and a solid background. These will facilitate developing specialized tools in XL-MS effectively. I will build these bioinformatics tools which will be introduced as a module for MaxQuant software. My fellowship will cover the following three tasks: i) the identification of the protein samples by conventional cross-linkers, ii) a complete identification workflow for the analysis with MS-cleavable cross-linker and iii) performing relative quantification of over many samples. The extended version of MaxQuant will allow scientists from mass spectrometry or structural biology laboratories to analyze their XL-MS data efficiently without any assistance of bioinformatics expert. Moreover, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular diversification of inhibitory neurons during development' under Horizon 2020.

assistant: **Concept**

Cortical interneurons are a diverse class of inhibitory neurons that play a particularly important role in the stability of the neural circuits underlying cognitive and higher order brain functions. A growing body of evidence suggests that perturbation of interneuron development can result in a variety of complex neuropsychiatric disorders, including autism, bipolar disorder, and schizophrenia. Thus, elucidating how interneurons develop and integrate into canonical brain circuits is crucial for understanding the brain in both health and disease. During perinatal development, intrinsic and environmental processes cooperate to establish the adult form of brain connectivity and behaviour control. To elucidate the molecular mechanisms underlying these interactive processes, I propose to combine genetic fate-mapping techniques with high-throughput single-cell RNA sequencing technologies to gain a detailed understanding of neurogenesis at the cellular level and elucidate how an immense diversity of interneuron subtypes is generated (Aim 1). Furthermore, I will utilize a novel retroviral barcoding strategy to reveal how much of an interneuron’s fate is genetically predetermined by lineage within progenitor zones of the ventral forebrain (Aim 2). Finally, I will study the genetic mechanisms that enable cell intrinsic programs to be shaped by environmental activity-dependent processes during the critical window of development (Aim 3). Candidate genes resulting from these aims will be functionally characterized through gain of function and loss of function methods. This proposal takes full advantage of my extensive training in viral and mouse genetic techniques, single-cell transcriptomic data processing, and in vivo manipulation of neuronal activity. I am confident that I will b