RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of the thalamocortical pathway - mechanisms underlying the establishment of thalamocortical connections and the specification of the cerebral cortex'.

assistant: **Objectives**

One of the most fundamental problems in developmental neurobiology is how neuronal connections are formed in the developing brain and how the functionally and anatomically distinct areas of the cerebral cortex are specified. Most of the information available so far comes from tracing connections in fixed material. I propose to use living brain slices and a combination of imaging techniques to directly examine the cellular interactions that underlie the development of the thalamocortical pathway. Specifically, I will address the following points: (i) examine the patterns of thalamocortical innervation, (ii) characterise the dynamic interactions between thalamic and cortical fibres, as well as between thalamic afferents and the cells of the subplate and cortical plate; (iii) investigate the role of specific factors that may be involved in the choice of the correct pathway and the formation of appropriate synaptic contacts (e.g. surface bound molecules, contact-triggered calcium influx, patterns of electrical activity).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Carbon Nanotube Devices for Integrated Circuit Engineering'.

assistant: **Concept**

The overall objective of this 3-year project is to develop a CMOS-compatible industrial process for the fabrication of field effect transistors based on carbon nanotubes (CNT-FETs). In order to solve the CNT manipulation and placement problems, two approaches based on template growth in engineered porous structures will be investigated. In the first one, CNTs will be grown inside porous alumina templates obtained by anodic oxidation of Al films.The originality of the method is that the pores are synthesised parallel to the surface of the substrate (instead of perpendicular as usual) which will greatly ease the contacting operations for the source, drain and gate electrodes of the CNT-FETs with large numbers of CNTs connected in parallel. In the second approach, CNTs will be grown in vertical pore structures obtained by nanolithography and reactive ion etching. In both cases, the catalyst particles (necessary for the nucleation and growth of CNTs at low to medium temperature) will be electrodeposited at the bottom of the pores prior to chemical vapour deposition growth of the CNTs.As the catalyst particles are confined inside the pores, high temperature surface diffusion is prevented during (or before) growth and the nanometric size of the particles is preserved, leading to uniform CNT diameters. Moreover, by using monocrystalline films or substrates at the bottom of the pores, we propose to deposit the catalyst particles in an epitaxial-type mode, which will lead to a perfectly controlled structure likely to induce chirality control for the CNTs. This point is of paramount importance for the future of CNT-based electronics. The project brings together 4 European partners with complementary skills, from 3 different countries. If the proposed approach is successful, only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Colposcopic Imaging Spectroscopy', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Foreseen ResultsThe prototype device COLSPEX to be used in this project, will be designed to utilize a wide range of spectroscopic signatures in order to maximize the probability of extracting visual information and to provide useful guidance to the gynecologist. The crucial point will be in its ability to correlate tissue spectroscopy with inflammation, cancer precursors (HPV infection), and cancer. Preliminary measurements with the imaging spectroscopy setup at LMTB, have demonstrated compatibility and non-interference with operating microscope which is similar to a colposcope. A clinically affordable device must be simpler and less expensive. It is expected that criteria for such an instrument will emerge from the INCO-COPERNICUS project. If development of COLSPEX is successful, it will permit cost reduction by reducing the number of patients requiring evaluation on a repeated basis, and facilitate immediate treatment.Survey of the World Health Organization demonstrated cervical cancer is the only cancer of women which does not show a clear geographical gradient of risk. The main cause of cancer of the cervix is infection of the cervix with human papilloma virus (HPV) particularly types 16 and 18. As many as 30% of sexually active women is estimated to have human papilloma virus HPV infection. The recent epidemiological studies clearly implicated HPV viruses are the possible etiologic agents in cervical neoplasm. In the European Community 25,000 new cervix cancer case registered every year, and the estimated deaths are around 13,000 per year.Laser-und Medizin-Technologie gGmbH, Berlin (LMTB), 2nd Department of Obstetrics & Gynecology, 2nd Department of Pathology, Semmelweis University of Medicine (SOTE) Budapest, University Medical School of Debrecen, Department of B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Workflow on intelligent distributed database environment' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The main objective of the WIDE project is to extend the technology of distributed and active databases, in order to provide added value to advanced, application-oriented software products implementing workflow techniques.WIDE is inspired by a coherent, component-oriented vision. Modern software systems should be built by composing, enhancing, and integrating software. Thus, flexible and extensible active rules and enhanced transactional models will be developed on top of existing database kernels, with a kernel-independent approach that warrants maximum portability and inter-operability. In particular, compliance towards the CORBA standard will be enforced.The technology developed in WIDE will be directly exploited for the enhancement of FORO, an existing workflow management system supporting the management of enterprise-wide processes and their constraints in a co-operative, distributed environment, developed by Sema Group sae.From a technical standpoint, WIDE will provide innovative, tightly integrated features concerned with advanced transactions (supporting distributed and asynchronous processing in the context of long-running and co-operative activities) and with reactive processing (supporting a rich event language as well as enhanced, flexible coupling to transactions).These features will be used to improve the services offered by FORO, in particular for what concerns distribution and flexibility, two strategically essential features for the next generation of workflow management systems. Access to a variety of heterogeneous sources (with some support for multimedia features) and inter-operability will also be considered within the scope of WIDE.The following results are expected:- an advanced workflow model, including innovative aspects such as alarms and time m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrating modeling into plant systems biology: Applications to auxin-driven plant morphogenesis'.

assistant: **Objectives**

Plant science is evolving from a reductionistic view on gene function to an integrated systems biology approach. Gene function of genes is now studied in the context of the dynamic behavior of physiological, cellular or developmental processes. Mathematical and computational modeling play a central role in this approach. During the initial Marie Curie Fellowship, I worked as a biomodeller at the primarily experimental VIB Department of Plant Systems Biology (PSB) in Ghent, Belgium. Based on this work, PSB has awarded me a “Young Leader” position, which includes a five year position as a group leader and budget for a PhD student. In this position, I have started up the group “Plant Systems Modeling” that is currently composed of myself (PI), a postdoc, three PhD students, and two Master’s students. The European Reintegration Grant would support further development of this group and thus ensure full reintegration. The Plant Systems Modeling group aims to build predictive models of auxin-driven tissue morphogenesis that can act as hypothesis-generators for wet-lab research. The project consists of the following two work packages: WP 1 To predict from first principles the spatio-temporal expression patterns of the major players of early vascular patterning in Arabidopsis, including PIN, AUX and auxin. This model will extend on the traveling-wave mechanism for auxin canalization that we have proposed recently (Merks et al, Trends in Plant Science, 2007). WP 2 To unravel the molecular mechanisms behind the recent observation that auxin oscillations regulate lateral root initiation (De Smet et al., Development 2007). For this we will develop a growing, multicellular model of auxin-flux-regulated patterning in the root basal meristem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Advanced polymer materials for drug delivery and tissue engineering'.

assistant: **Concept**

Drug delivery and tissue engineering are rapidly evolving areas of technology that require a Multidisciplinary approach to research. Marie Curie Fellows will gain a thorough training in aspects of nanotechnology; materials characterization and cell-material interactions with the aim of creating new advanced polymer materials for use in human medical applications. Examples of research outcomes under investigation include: site-specific targeting of drug molecules to disease sites, controlled release of protein-based drugs and the engineering of human tissues. The Group has an established reputation in fundamental polymer science, applied pharmaceutical and tissue engineering research, and technology transfer. Fellows will have the opportunity to become fully involved in these activities inline with their future career goals. Applicants should be on or about to commence a postgraduate programme of research in an area relevant to the opportunities we can offer. We are particularly keen to identify students where our training will provide significant added value to the student through the provision of complementary skills to those learnt in their home institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding puzzles in the gendered European map brain drain in physics through the cultural looking glass' under Sixth Framework.

assistant: **Concept**

Over the next decades the general decrease in populations will affect all sectors of highe r education and research in Europe. Natural sciences are encountering increasing problems with recruitment, especially of female physicists students. It is a matter of utmost concern that well-qualified female scientists seldom reach top-level positions to the same extent as their male counterparts and often leave the research system prematurely. This is a fact that has been well established in a number of studies, no tably the SHE-figures, the Helsinki Group Reports, and the ETAN- and ENWISE Reports. The overall picture is a dismal one; yet an interesting configuration of cultural diversity appears on a gendered map of physicists. It is comparatively easier to attract female students in eastern and southern European countries than in the north, and career paths seem to follow different patterns. The primary objective of the UPGEM project is to identify relevant local cultural-historical processes behind brain-drains" of female physicists, who are leaving the field despite having the same formal qualifications as their male colleagues. This implies identifying the informal ways in which careers are shaped in various cultural contexts, and their relationship to "the four P's" (prestige, payment, pleasure, policy). Through close-up (qualitative) studies of the working environment of female academic staff in physics institutes at six universities distributed along the north/south and the east/west axes of the European map, the project will provide a complement to the statistical surveys and recommend more effective policies countering brain-drain. This is not just a question of gender equality. The saving effect of keeping just 10% of potential female physicist brain-drainer s throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovations for vaccines against helminth infections', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Infections with parasitic worms (helminths) continue to cause a massive global health burden. Yet, effective vaccines to enable control and elimination of helminth infections do not exist. Primary reasons for this are that target discovery approaches are not well-developed, protective immune mechanisms are only partially clarified at best, production platforms tailored to specific helminth vaccine requirements are not available, and a pipeline for selecting and rapidly progressing pre-clinical and clinical vaccine candidates is generally lacking. Moreover, controlled human infection models are only now being developed and optimized for some of the most important human helminths. These models have not yet been widely implemented in vaccine development programs to date.The objective of WORMVACS2.0 is to establish an effective pipeline to support helminth vaccine development focusing on schistosomes and hookworms, and ultimately the control and elimination of some of the world’s most devastating and persistent Neglected Tropical Diseases (NTDs). We aim to achieve this through the development and application of an innovative approach leveraging controlled human infection models, novel platforms for helminth vaccine/vaccine antigen production, experimental animal models, and improved target discovery methodology applying state-of-the-art immunological profiling to identify correlates and signatures of protection. WORMVACS2.0 will advance scientific and clinical knowledge of host immunity in response to helminth infection, apply innovative and sustainable platform technologies tailored to the next generation of effective vaccines against helminth infections of global importance. The project will produce a diversified portfolio of hookworm and schistosome vaccine candidates re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Epitaxial silicon foil solar cells with interdigitated back contacts' (EpiSil-IBC).

assistant: **Innovation**

The leading technology in the photovoltaic market today is the single junction crystalline silicon (c-Si) solar cell. Since there is little room for further improvement beyond current efficiency records and to reduce material costs, the industry trend in c-Si technology is pushing towards thinner and thinner cells, which are harder to handle without breaking. The aim of this proposal is to realize a solar cell based on ultra-thin (<50 µm) silicon foils with contacts on the back side of the cell. New processing techniques are required in which the foils are bonded to a glass substrate, such that they are never handled free-standing. The goal of this innovative solar cell is to surpass the current state-of-the art efficiencies of thin silicon foil solar cells by using, low-cost and high yield processing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel Flexible Sheet Forming for High Value Manufacturing' to be submitted under Seventh Framework.

assistant: **Abstract**

Developing environmental friendly & sustainable manufacturing technologies has become a driving force to maximise resource efficiency, to reduce energy consumption & environmental pollution. In addition, with ever increasing global competition, it is crucially important for European manufacturers & SMEs to develop core competence of future advanced manufacturing technologies.This IIF project proposes the development of a new flexible sheet forming process to support sustainable technologies of rapid manufacturing high value-added, small batch & customised sheet metal parts, with reduced costs & lead time. The project will support an experienced researcher, Dr Bin Lu, of Shanghai Jiao Tong University (SJTU) China to visit the Department of Mechanical Engineering of the University of Sheffield (USFD) UK for 24 months. Bringing his unique knowledge & expertise in the flexible sheet metal forming technologies and skills in numerical modelling & optimisation techniques, Dr Lu will be focusing on the development of a new concept of Laser Assisted Double Side Incremental Forming using WaterJet (DSIF-LWJ), design of a bespoke prototype machine & manufacture of  three sheet metal parts for industrial demonstration. The project will benefit from transfer of knowledge to the host USFD in fundamental research of combined effects of laser & waterjet on material plastic deformation as well as advanced flexible sheet forming, hybrid process control & system integration technologies.By demonstrating scientific advances & economic potentials of the flexible sheet forming of DSIF-LWJ, the project will not only enable the share of the candidate’s knowledge & expertise, develop long-term collaborations, but also make a contribution to help European manufacturers & SMEs enhance their techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Incorporating protein backbone flexibility and induced-fit in drug discovery' (INSILICODRUGDISCOVER).

assistant: **Innovation**

The activity of many proteins, strongly changes when small ligands dock into well defined cavities of the protein receptor. For proteins involved in disease-related metabolic pathways novel artificial ligands may act as drugs. In the drug discovery process, high-throughput in-silico screening(IS-HTS) methods are increasingly used to identify lead compounds, i.e. ligands that bind to a target protein with high affinity. Existing methods have significant shortcomings, because the time spent on each ligand is very short. In an ongoing collaboration with the Barcelona Supercomputer Center (BSC) I implemented FlexScreen, the IS-HTS program developed by the host group at FZK, on the Cell, a new processor developed by BSC and IBM into the next generation of ultra-fast peta-flop supercomputers. The individual processing unit of these new computers is distributed separately and delivers about 250 times the performance of a PC at roughly the same cost.  In the mobility project I will exploit this unprecedented computational power to incorporate new ideas into the IS-HTS method, not achievable with standard computational hardware. Continuing the collaboration with BSC I will develop improved biophysical scoring functions and novel docking strategies. I will also address a long-standing problem of IS-HTS methods: the change of protein conformation upon binding (induced fit). In collaboration with the cancer research center in Heidelberg (DKFZ) I will apply these new methods to search for new lead compounds to DNA-methyl-transferases to develop new therapies for cancer.  The results of this research will reduce the time and cost of the initial stages of drug design, not only in academic but also for industrial projects, increasing the competitiveness of the European pharmaceutical i