RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spatial fractionation of the dose in proton therapy: a novel therapeutic approach' (PROTONMBRT), addressing dissemination and exploitation.

assistant: **Impact**

Radiotherapy (RT) is one of the most frequently used methods for cancer treatment (above 50% of patients will receive RT). Despite remarkable advancements, the dose tolerances of normal tissues continue to be the main limitation in RT. Finding novel approaches that allow increasing normal tissue resistance is of utmost importance. This would make it possible to escalate tumour dose, resulting in an improvement in cure rate. With this aim, I propose a new approach, called proton minibeam radiation therapy (PROTONMBRT), which combines the prominent advantages of protons for RT and the remarkable tissue preservation provided by the use of submillimetric field sizes and a spatial fractionation of the dose, as in minibeam radiation therapy (MBRT). The main objectives of this project are to explore the gain of therapeutic index for radioresistant tumors, to disentangle the biological mechanisms involved and to evaluate the clinical potential of this novel approach. For this purpose, a method for minibeam generation adequate for patient treatments and a complete set of dosimetric tools will be developed. Then, tumour control effectiveness will be evaluated, and the possible biological mechanisms involved both in tumour and normal tissue responses will be disentangled. The gain in normal tissue recovery can foster one of the main applications of proton therapy, paediatric oncology, as well as open the door to an effective treatment of very radioresistant tumours, such as high-grade gliomas, which are currently mostly treated palliatively.


**Keywords:** Medical physics, dosimetry, radiobiology, normal tissue toxicity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative and efficient air quality management system for a healthy, confortable and safe in - vehicle environment' to be submitted under Fifth Framework.

assistant: **Abstract**

The project aims to develop an innovative, efficient and modular air quality management system in-vehicles able to provide a healthy, comfortable and safe environment for driver and passengers. The new system is based on the destruction of gaseous pollutants using an innovative plasma catalytic process and the removal of fine aerosol particles with an advanced electrostatic technology The developed compact air conditioning prototype for vehicles will be equipped with an advanced air monitoring system and enhanced driver/vehicle interfaces for air quality awareness and preventive maintenance information. On-board prototypes will be first tested in automotives. However, the technological approach may concern other kind of mobile cabins (buses, trucks, rails, aircrafts,...).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing the electric car that charges itself: Lightyear One' (LIGHTYEAR).

assistant: **Concept**

Lightyear, an international team of 90 engineers including triple winners of the World Solar Challenge, experienced engineers (180+ years) from the aerospace, racing and automotive industry (e.g. ASML, Tesla, Ferrari and Inalfa) and alumni of the Eindhoven University of Technology, develops the first commercially available electric solar car in the world that charges itself: the Lightyear One. The extremely efficient family car will be able to drive for weeks or even months on self-generated solar energy. The engineers started from the rationale that the car should be incredibly efficient, in order to make an independent entity having its own energy source. To achieve this, Lightyear had to minimize the car’s energy consumption and maximize its energy input, by using four inwheel motors instead of one rigid motor, lowering the total mass of the car by using lightweight biobased materials, redesign to improve aerodynamics, developing a new battery pack; integrating their in-house custom developed solar panels on the roof and the bonnet of the car. Result: a car that excellences in driving range, in weight, in energy consumption, sustainability and operation costs compared to market's-state-of-the-art. Range anxiety, dependency on energy (charging) infrastructure and the use of non-renewable/inefficient energy sources to charge your car will belong to the past. In this project, Lightyear aims to develop, validate and demonstrate the first Lightyear One and associated assembly line, bringing their innovation from TRL 5/6 to 8.  Lightyear expects to produce the first 10 signature cars in 2020, and start serial production from 2021 onwards. EBITDA is expected to turn positive in 2021 with a fivefold increase of FTEs. This development  reinforces competitiveness and performan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Extraction of information on muscle control during movements'.

assistant: **Objectives**

Electrical properties of muscles have been under intense scientific and clinical investigation for decades. From the neurophysiologic point of view, it is essential to achieve a deeper understanding of neuromuscular alterations and of their relation to work condition, immobilization, overtraining and microgravity. Measurable indicators of incipient degeneration, effectiveness of treatment, and preventive actions are required to practice evidence based medicine, rehabilitation and training of athletes. Technical difficulties associated with recording and analysis of electromyograms have limited the accuracy with which the characteristics of individual motor units can be established during movements. The existing information extraction techniques have mainly been applied to the isometric muscle contractions, with the muscle geometry kept constant during the measurement session. On the other hand, the contractions of human muscles are almost always dynamic, with the muscle moving with respect to the skin. The main objective of the iMOVE project is to design and implement automated signal processing techniques capable of extracting the information about the individual motor units from the dynamic surface electromyograms recorded during controlled dynamic contractions of skeletal muscles, to study the feasibility, efficiency and repeatability of information extraction during movements, and to define the recommendations for sensors, sensor placement and signal processing in dynamic conditions. Possible collateral applications of the proposed project include objective assessment of effectiveness of rehabilitation and training of athletes, prevention of work-related neuromuscular disorders and diseases, and monitoring of the musculoskeletal deterioration in the microgravity env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Renaissance Project: Towards a strategic orientation and associated toolkit to support global UCD that is appropriate and accountable to local culture' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Companies strive to develop products en masse for a global market. The challenge for companies is to maintain product quality, consistency and profitability, whilst ensuring that products meet and respect local and cultural norms. When technology design contravenes expectation, a product will fail, which can be disastrous not only for a company’s profits but dangerous in safety critical situations, and a potential source of structural instability in complexly interconnected sensitive industries such as finance. The Renaissance Project Project will establish the first steps towards a strategic orientation and associated toolkit to support global UCD that is appropriate and accountable to local culture. There are three main research objectives: i) to capture information related to knowledge management strategies for UCD; ii) to establish a toolkit to support appropriate design in disparate cultures; iii) to disseminate this knowledge within industry and academia. This research directly builds on the researcher’s prior Marie Curie ToK research, during which a design framework and evaluation tool was developed at Philips Research in Eindhoven to support socially intelligent design of products. By exploring new and pertinent research findings, capitalizing on existing international industry and academic partners (whilst simultaneously seeking to extend this network of interest), and addressing social need to ensure design fits culture, The Renaissance Project research findings promise to lead to new understanding and support for technology design and innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Non-invasive computational immunohistochemical staining based on deep learning and multimodal imaging' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In most European countries, the diagnosis of cancer is achieved by examination of haematoxylin-eosin (HE) staining by an experienced pathologist. Nevertheless, several other diagnostic approaches exist (e.g., immunohistochemical staining) which are not applied routinely for all cases due to their technical complexity, duration, and cost. Therefore, an important unmet medical need for fast, non-invasive, and label-free immunohistochemical staining based on molecular imaging without laborious sample treatment exists. This demanding challenge will be tackled in STAIN-IT using a non-invasive label-free measurement technique called multimodal imaging (e.g., the combination of coherent anti-Stokes Raman scattering, second harmonic generation, and two-photon-excited fluorescence). The multimodal images will be analysed using deep learning approaches, such as convolution neural networks (CNNs). These CNNs are utilized to mimic immunohistochemical stainings. CNNs are neural networks that learn the feature representation of the data, which is optimally suited to model a specific immunohistochemical staining. In STAIN-IT, the staining models will be developed along with the methods to quantitatively understand the nonlinear behaviour of the CNNs. With the envisioned approximation approaches for CNNs, these models no longer act as black box systems, and a quantification of tissue changes associated with the staining models can be achieved. For the very first time, STAIN-IT will develop a label-free, non-invasive, labour-inexpensive, and fast computational immunohistochemical staining, which can be easily implemented into clinical routine yielding increased diagnostic reliability and a better understanding of disease pathogenesis. A fast test of the antigen KI-67 in an intraoperativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Modelling the dynamics of resilience in coupled social-ecological systems'.

assistant: **Concept**

The challenges and uncertainties of global change and the complexity and unpredictability of the dynamics of complex social - ecological systems demand for new approaches to ecosystem and resources management.Strategies for adaptive management aim to strengthen the flexibility and resilience of the system to enhance its capacity to cope with unexpected change. Resilience is the potential of a system to remain in a particular configuration, to maintain its feedbacks and functions and to reorganise following disturbance driven change.The dynamics of coupled social-ecological systems and factors determining their resilience are still largely unknown. The importance of feedbacks, self-organisation, structural characteristics, such as diversity, redundancy etc., have been recognized, but their integrated analysis and understanding needs further research.The aim of the proposed research is to investigate system properties and processes that build and maintain a system's resilience. Special emphasis will be put o n the analysis of the dynamics of resilience in coupled social-ecological systems (SESs) to provide a basis for adaptive ecosystem and resources management.This shall be achieved through cross-system analysis and the development of coupled models of ecological and social systems. Simulation models will be used to investigate the role of organisational structure, of processes at different scales, positive and negative feedbacks, information flow, level of interaction, and other factors for the resilience of the coupled system.The project will focus on systems where people and ecosystems share a common resource, e.g. water, or where an ecosystem is managed by the people benefiting from its services.The integrated human - nature system is treated as a complex adaptive sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using senolytic agents to suppress the toxicity of chemotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Many of the clinically used cancer chemotherapies have considerable short-term side effects, including fatigue, bone marrow suppression, nausea, diarrhea, and hair loss. Long-term side effects include cognitive impairment, organ dysfunction, and even secondary cancers. A body of evidence indicates that senescent cells induced by chemotherapy in non-cancerous tissues play a major part in these toxicities of chemotherapy. As part of the SENCAN grant, we have developed a cocktail of two drugs that is efficient in killing senescent cancer cells. This so-called senolytic cocktail synergizes strongly with chemotherapy in eradicating tumors in experimental animals. The senolytic cocktail acts independently of the genetic context of the cancer, thus demonstrating superior efficacy compared to other senolytic agents, which are context-dependent. We will test in this proof-of-concept grant whether this cocktail can also reduce the side effects of cancer chemotherapy by eliminating the senescent cells from non-cancerous tissues in mice. We use transgenic mice that carry a reporter gene that is activated in senescent cells and hence, tissues become luminescent when non-tumor-bearing animals are treated with chemotherapy. In pilot experiments, we have seen suppression of the luminescent signal when mice are treated with our senolytic cocktail post-chemotherapy. In this application, we plan to investigate the effect of the senolytic cocktail on vital organs that are often affected by chemotherapy: the bone marrow, the heart, and muscle (fatigue). If successful, the case for use of the senolytic cocktail in combination with cancer chemotherapy would become even stronger: not only have we already shown that the cocktail synergizes with chemotherapy in eradicating tumors in vivo in SENC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Bioengineering in health ERA chair' (MOBILIsE), addressing dissemination and exploitation.

assistant: **Impact**

MOBILIsE aims to recruit an outstanding Researcher to act as the ERA Chair Holder to the National Institute of Biomedical Engineering (INEB). She/he will establish a new research direction in Molecular Bioengineering focused on precision medicine, namely in targeted therapies and molecular diagnosis, and create a synergic and cohesive research environment among key stakeholders (academy, research institutes, clinicians and industry) in the Porto region: the MOBILIsE hub. The MOBILIsE project will boost the translation of the design of new molecular targets to the application of diagnostic tools and therapies targeted to the major health challenges, with particular focus on cancer, infection, neurodegenerative diseases, and tissue repair/regeneration that have been explored at the institute. INEB is already recognized for its fundamental work in protein/cell-materials interactions and in the development of nanotechnology tools for targeted controlled drug delivery. Yet, the potential and projection at international level of cross-disciplinary research, like the application of nanomedicine to cancer and neurologic disorders, is still limited. This has a major impact on funding attraction, transfer of technology, and translational potential of the research developed. Hence, this project will hire an expert in Molecular Bioengineering to install an internationally competitive research group focused on precision medicine. The group will exploit nanotechnology tools to discover new molecular targets that can be explored in the design of new diagnostic and/or therapeutic systems. The MOBILIsE project will promote the integration between biomedical engineering, biology and medicine, by focusing on (vital) interactions at the molecular level with impact on human health. Ultimate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of nutritional vesicles for precision diagnostics and therapeutics for metabolic diseases' under Horizon Europe.

assistant: **Concept**

The NutriEV project explores the pivotal role of extracellular vesicles (EVs) derived from food in nutrition. These nutriEVs are envisioned to serve as superfoods and nutritional biosensors. The project integrates various disciplines, including nutrition, microbiome research, glycan analysis, molecular biology, nanoreagent assembly, biosensors, organoid technologies, in vivo models, and clinical research.NutriEVs obtained from raw and fermented foods are a model for our research. Investigating the glycans associated with NutriEVs will provide insights into how these vesicles may deliver their nutritional cargo to cells. NutriEVs can withstand the digestive process, influencing the gut microbiome and other gut-resident cells, including their secreted EVs. Subsequently, they transcytose across the gut wall into the bloodstream, impacting cellular metabolism and disease.The project delves into the intricate interplay between dietary EVs, the gut residence cell, the microbiome, and their associated EVs. We aim to understand their role in gut health, obesity, and metabolic regulation through a comprehensive array of in vitro, in vivo, and clinical investigations. These EVs are detected in sweat with unique molecular signatures, providing non-invasive biomonitoring technologies to assess nutritional impact. These technologies can potentially revolutionize our ability to evaluate the influence of nutrition. The successful completion of the NutriEV project presents promising translational opportunities for both the food industry and medicine.


**Keywords:** Nutrition, gut, microbiome, glycans, plant, nutrition-derived exosome-like vesicles, EV, transcytosis,  precision monitoring via sweat, obesity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Collagen in Cancer: from the regulatory fibril forming function of collagen V in development to its implication in tumor progression'.

assistant: **Objectives**

Molecular mechanisms that determine survival, differentiation and movement in multicellular organisms depend on extracellular matrix (ECM) integrity and cells interacting with the ECM. Collagens are the most abundant proteins in the ECM. Their primary function is to provide structural support to cells and to maintain biomechanical integrity of tissues. However, collagens are not just structural proteins. They act as extracellular modulators of signaling events and serve critical regulatory roles in various cell functions during embryonic development and adult homeostasis. It’s increasingly important to understand these mechanisms in cancer biology. Disruption or imbalance in collagen dynamics is associated to tumor formation and progression by directly acting on the development of tumoral stroma, cancer-associated fibroblasts and angiogenesis. Hence, targeting aberrant ECM may provide an effective avenue to combat cancer. Fibrillar collagens are among the first components to be compromised in cancers. This research proposal focuses on the role of the regulatory fibril forming collagen V whose upregulation has been reported in several types of human tumors. Combining my skills in cancer biology with the expertise of the host lab in ECM biology, I will investigate the versatile regulatory roles of collagens in ECM dynamics. I will focus in particular on the formation of the tumoral microenvironment and the complex mechanisms by which the properties of ECM instruct the development of cancer.