RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HARMONISED NUTRIENT LOAD REDUCTION APPROACHES WITHIN SAFE ECOLOGICAL  BOUNDARIES IN CATCHMENTS LOCATED IN NW EU' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In 2015, the ecological status of 75-90% of surface waters in NW Europe was reported to be less than good. Diffuse pollution with nitrogen (N) and phosphorus (P) from agriculture, together with point sources of N and P pollution from wastewater plants and industry, are a major cause of this failure to achieve good ecological status. Climate change is likely to exacerbate the pollution risk. Clearly, there is a huge challenge to implement effective mitigation measures to reduce nutrient loadings to air and water to meet desired environmental targets against the background of a changing climate. The synergies and tradeoffs between management actions to mitigate climate change and those to mitigate N and P pollution need to be clarified to develop effective local, regional and national policies. Governance arrangements to implement and monitor the necessary actions need to be better integrated, requiring a consistent and coherent set of environmental indicators. The overall objective of NEW-HARMONICA is to assess and co-develop a harmonised systemic approach to prioritizing an effective suite of N and P pollution mitigation measures and indicators to meet local to regional environmental targets. To achieve this objective, an experienced NEW-HARMONICA consortium (4 partners from 3 countries) with complementary expertise, skills and networks will work on 4 N and P-polluted cross-border river basins in NW Europe. All partners are involved in an established NW Europe Policy-Science Working Group (PSWG) who together with local catchment stakeholders play a central role in NEW-HARMONICA. NEW-HARMONICA’s approach is based on a combination of technical assessments, including quantification of N and P flows and load-reduction targets in the study catchments, assessments of governan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Domain-optimised parallelisation by polymorphic language embeddings and rewritings' (DOPPLER).

assistant: **Innovation**

Concurrent and parallel programming are becoming indispensable forexploiting modern hardware. Because possible speed increases of singleprocessors have reached their limit, increasing transistor count willyield more, but not necessarily faster cores, and this for theforeseeable future. This means that, from now on, parallelism insoftware will have to double every 18 months to keep up withhardware. This problem has been identified as the ``Popular ParallelProgramming'' grand challenge by the computer architecture community.The proposed project will research new ways to solve this challenge.We start with a set of domain-specific languages which naturally admita high degree of parallelism. The domain specific languages areintegrated in a common host language using polymorphic languageembeddings. Such embeddings provide a high degree of abstraction,which gives considerable freedom in their actual representation andimplementation. The new direction taken by this proposal is to combinepolymorphic embeddings with optimizing rewritings in a stagedcompilation process. This can lead to highly parallel and efficientimplementations on a variety of heterogeneous hardware.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Infection, latency and reactivation of novel human herpesviruses in immunodeficient patient groups.Definition of markers and development of diagnostic reagents' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this proposal is to define human herpesvirus 6 (HHV-6) and 7 (HHV-7) markers of reactivation and of overt infection and to develop immunologic and molecular diagnostic reagents that allow the early identification of patients at risk of HHV-6-, and possibly HHV-7-associated disease.(i) To analyse the function of HHV-6 104kDa immediate-early-1 (IEI-I) protein. IE-1 has been shown to be one of the very few genes that are transcribed at immediate-early times of infection. It is likely to play a key role in initiating HHV-6 lytic replication and thus the analysis of this protein will enlighten mechanisms of HHV-6 reactivation. As it is the only IE-protein of HHV-6 that bears no detectable homology to other known genes it will be an excellent marker for the switch from latency to reactivation.(ii) To identify the glycoproteins predicted to be encoded in HHV-6 U21, U22, U23, and U47 genes. As these glycoproteins bear no detectable similarity to other herpesvirus or cellular glycoproteins, they are likely to enlight the mechanisms of virus interaction with the host cell and with the immune system, and will also serve as excellent markers.(iii) To ascertain if immunodeficient conditions that lead to reactivation of HHV-6 also lead to reactivation of HHV-7;(iv) To map the gene encoding the HHV-7 highly immunogenic phosphoprotein pp85 (v) To express the genes that appear to be markers of reactivation in procaryotic and eukaryotic systems, derive immunologic reagents.(vi) To identify those pathologies and tissues with a high viral load and determine whether in these samples active infection can be probed for expression of the genes characterised above.(vii) Final set-up of immunologic and molecular reagents that function as specific markers of viral reactivation or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing computational chemistry with new accurate, robust and scalable electronic structure methods' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of this proposal is to tackle two of the greatest challenges in quantum chemistry: (i) extending the applicability of highly accurate wave function methods to large molecular systems, and (ii) developing accurate and robust multi-reference methods that can be used for studying important but very difficult problems in transition metal chemistry, catalysis, and photochemistry. Solutions to these problems have now come within reach due to three advances we recently reported: first, the steep scaling of the computational cost with molecular size can be reduced to linear by exploiting the short-range character of electron correlation (local correlation methods). Second, the accuracy, efficiency, and robustness of these local correlation methods can be strongly improved by new  tensor decomposition approaches and the inclusion of terms depending explicitly on the inter-electronic distances (F12 methods). Third, the development of highly complex electronic structure theories can be greatly facilitated and accelerated by new automated tensor network evaluation techniques. We are certain that by combining and generalizing these advances the long-standing problems (i) and (ii) can be solved. We will focus especially on highly scalable algorithms in order to use massively parallel computer systems efficiently. For linear-scaling methods this means that the size of the molecules that can be treated in a fixed time will grow linearly with the number of available processors. We will furthermore explore new multi-reference ansätze and implement analytical energy gradients and response properties for local methods. Hybrid and embedding methods to account for solvent and environment effects will also be investigated. It is our priority to make our new methods as easy to us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring New Phenomena through Flavour Changing Neutral Currents with LHCb' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Standard Model (SM) of particle physics has been very successful in describing phenomena at the smallest scales, yet we know that it is incomplete.It does not, for example, explain the matter-antimatter asymmetry in the universe or provide a dark matter candidate.Attempts to solve these open questions do so by introducing as yet undiscovered particles.If these particles exist, they will appear as virtual particles in quantum loops, where they can affect the rate and angular distributions of particle decays.The main objective of this proposal is the study of rare flavour changing neutral current transitions in b-hadrons, where a b-quark decays to an s- or d-quark and a pair of muons.These processes are highly suppressed in the SM and the presence of new virtual particles can therefore have a comparably large effect.In particular the decay of a B-meson to a K* meson and a muon pair provides many observables that have excellent sensitivity to particles beyond the SM.I propose a direct fit of the generalised couplings in this decay using the full data sample recorded by the LHCb collaboration.To achieve optimal sensitivity to possible contributions beyond the SM the fit algorithm will use the full available information of the final state (decay angles, decay flavour and invariant mass of the  dimuon system).A benefit of this approach is that the fit can help to constrain sources of theoretical uncertainty that can otherwise limit the sensitivity.In addition, I propose to perform a first three-dimensional angular fit of the decay of a Bs meson to a phi meson and a muon pair.This fit will determine several interesting CP-asymmetries with high sensitivity to contributions beyond the SM.To complete the picture of semileptonic B-decays, I will study b-quark to d-quark transi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The response and control of semiconductor laser arrays under optical feedback' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

(a) To develop a consistent and rigourous theory to describe the dynamical response of semiconductor laser arrays with feedback. This theory should apply to high power and surface emitting laser, multimode systems and large bandwidth systems. (b) To analyse recent experimental results (i.e. spatial mode selection, phase locking, feedback instabilities, coherence collapse) in terms of these new theoretical models. (c) To verify the predictions of point (a) in a careful designed experiment on vertical cavity surface emitting laser arrays. (d) To apply new mathematical tools learned from nonlinear dynamical system theory, high performance computation and simulation to determine feasible feedback schemes to control the coherence of the laser array device. (e) To experimentally measure the spectral linewidth properties of semi- conductor laser arrays for different levels of potical feedback. (f) To establish a new interdisciplinary group of international researchers capable of modeling, building and testing novel configurations for semiconductor laser arrays. The key being here the determination of the feedback scheme required to produce line narrowing of the device and phase locked operation. (g) To provide high quality research and technical training for experimental and theoretical laser physicists with an emphasis on semiconductor optoelectronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of hepatic type cell polarity during Plasmodium liver stage infection' in the context of a Seventh Framework call.

assistant: **Objectives**

Plasmodium parasites are the causative agents of malaria, amongst the most prevalent and severe human infectious diseases.  Plasmodium sporozoites are injected into the mammalian host during the bite of an anopheline mosquito, and rapidly migrate to the liver where they invade hepatocytes.  Once inside a hepatocyte, a single sporozoite initiates a developmental program whereby it gives rise to thousands of merozoites, which are released into the blood stream a few days later, initiating the clinical phase of malaria infection. Sporozoites are capable of entering any cell type tested thus far in vitro, and can even initiate transformation into exo-erythrocytic forms extracellularly, but can only undergo schizogony and generate infectious merozoites in a particular environment, which appears to be provided exclusively by hepatocytes and hepatoma cell lines. This strongly suggests a crucial role of the host cell in providing a distinct niche that supports Plasmodium growth and development.  One distinctive feature of hepatocytes when compared to other epithelial cells is their mode of polarization. The general importance of host cell polarity for a liver stage Plasmodium infection has not been investigated. I propose to analyze the role of one unique aspect of hepatocyte biology, the hepatic mode of polarization, in creating the hepatocyte niche that uniquely supports liver stage Plasmodium growth and development.  I will address this question by taking a broad approach to characterize the stages of Plasmodium development in WIF-B cells, which display hepatic polarity and to characterize the polarization state of Huh-7 cells, a hepatoma line widely used to assess infection. In a complementary candidate molecule approach, I will characterize the requirement for the host EMK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Informal governance in the european union'.

assistant: **Objectives**

The objective of this research project - Informal Governance in the European Union - is to provide a systematic analysis and normative appraisal of informal governance in the EU, which is understood as patterns of personalized networks of policy-makers operating outside the institutional and legal framework of the Union. The project will be centered on an international conference and the subsequent publication of an edited volume aimed at the academic market as well as the general public in order to disseminate the results of this research project as widely as possible. The conference will bring together a number of researchers working on various aspects of informal governance in the EU as well as academic experts and practitioners acting as discussants. This meeting will help to establish a continuous dialogue between these communities about the nature and effects of informal governance in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hit-to-Lead Development of potent broad-spectrum coronavirus fusion inhibitors' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Covid-19 pandemic emphasized the urgent need for efficient broad-spectrum antiviral drugs against potential future coronaviruses (CoV) strains that may cause the next COVID pandemic. A critical stage during infection is the fusion of the viral envelope with the host-cell membrane, which depends on the conserved S2 domain of the viral Spike (S) protein. Hence, targeting the S2 domain is a promising approach to achieving pan-CoV inhibition. Since MERS- and SARS- S proteins bind to different cellsurface receptors through the rapidly diversifying S1 domain, we reasoned that compounds that inhibit both must target the S2 domain. We developed and performed a robust fluorescence-based high-throughput screen of 173,227 unique compounds and classified them based on their ability to inhibit infection of pseudoviruses bearing either MERS or SARS-2 S proteins at single-cell resolution. To our knowledge, this is the largest screen performed to date. This analysis identified several potent broad-spectrum small molecules that inhibit S protein mediated infection at sub-micromolar concentrations. Moreover, the compounds we discovered obey Lipinski's rule of five, indicating that they can potentially become drugs to prevent viral transmission. This project aims to develop two of the most promising broad-spectrum CoV small molecule inhibitors to create more clinically ready compounds with up to 100% inhibition activity that could be administered orally to reduce hospitalizations, prevent chronic effects, and reduce mortality. The technical work in the project is focused on lead optimization leading towards broad-spectrum antiviral drugs against future outbreaks of bat-borne viruses. The project also comprises pre-commercialization activities, where IP protection and commercialization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'European ECOsystem for greeN Electronics'.

assistant: **Concept**

Many different environmental impacts arise from electronics, and the handling of electronic waste (e-waste) is rising quickly to the top of the agenda. E-waste is a significant issue for Europe: Improving its management is an explicit goal of the Green Deal objectives and the Circular Economy Action Plan (3.1. Electronics and ICT). However, due to the requirement to involve the whole value chain, from raw material suppliers to consumers, the complex material background and supply chain, as well as the multitude of competing interests, achieving circularity in the electronics industry is challenging.The main aim of the EECONE project is to reduce e-waste on a European scale.To this end, 54 entities (47 partners, 2 associated partners and 5 affiliated entities) from 16 European countries covering different sectors of activity have joined forces to propose practical ways of reducing the volume of e-waste in the EU. Crucially, the entities that make up EECONE represent all parts of the value chain. EECONE’s approach is interdisciplinary, covering the social, economic, technological, and policy aspects.The environmental impact arising from e-waste can thus be reduced by working in three principal areas:a) Increase service lifetime of electronic products by application of ecodesign guidelines for increasing their reliability and their repair rate, thereby reducing the volume of e-waste. Reduction and replacement of materials to decrease the impact of e-waste.b) Improved circularity by reusing, recycling, and waste valorising materials/elements from electronic products.EECONE’s vision is to develop and embed the constraints linked to managing the end-of-life of electronic products from the very beginning – in the development or process design. EECONE is paving the way as a fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Healthy Aging Through Internet Counselling in the Elderly' to be submitted under Seventh Framework.

assistant: **Abstract**

Diabetes mellitus, hypertension, obesity, hypercholesterolemia, smoking and physical inactivity are common in elderly persons and are all associated with an increased risk of myocardial infarction, stroke and dementia. Efficacious treatments of these cardiovascular diseases are available, but in elderly patients with multiple cardiovascular diseases and risk factors however, treatment is currently insufficient. Optimisation of management of these diseases in order to decrease the burden of cardiovascular disease and its long-term complications is urgently needed.In this project we will develop and evaluate an innovative intervention strategy to improve pharmacological and non-pharmacological treatment for cardiovascular disease in elderly patients. First, data from three large ongoing clinical trials on multi-component vascular interventions in the elderly will be used to explore efficacy and feasibility of various treatment regimens. Second, an innovative and interactive internet platform for self-management of vascular diseases in the elderly will be developed. Interactive support by practice nurses and patient’s own physician and monitoring of adverse events will be integrated. Third, the efficacy of access to this new internet platform will be evaluated in a randomised controlled trial in 2600 elderly with multiple cardiovascular diseases. Patients randomised to the control condition will receive regular care. Primary outcome is a composite score including three vascular risk factors: systolic blood pressure, LDL cholesterol and BMI. Secondary outcomes are new cardiovascular events, handicap, cognition and survival.This flexible internet-based intervention strategy can be easily translated and adapted for use in different health-care systems in the EU. It will allow