RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Bergen advanced training site in multilingual tools'.

assistant: **Innovation**

Doctoral students from EU/EAA member states are invited to apply for 3 -12 month stays at BATMULT (Bergen Advanced Training Site in Multilingual Tools) at the University of Bergen. BATMULT consists of closely interrelated research units working together to offer interdisciplinary training in multilingual resources and tools, with special reference to the Scandinavian languages and their interaction with other European languages. The training site provides training through courses project work and individual supervision. The BATMULT site is able to provide excellent competence in the fields of multilingual resources (term banks, large-scale Corpora, large-scale parallel grammar development, large-scale lexicon development, word nets, thesauri and semantic mirrors, text coding and standardization) and multilingual knowledge tools (machine translation and multilingual transfer assessment, multilingual lexical semantics, language production systems, language learning tools and editorial support tools). Trainees at BATMULT will be able to rapidly embed advanced and targeted research expertise in their competence profiles, allowing them to gain a better position in the job market. The site is open to fellows doing a PhD in computational linguistics, especially with reference to multilinguality and Scandinavian languages; fellows in computer science who work on new algorithms and who wish to extend and deepen their linguistic knowledge, also with reference to Scandinavian languages; fellows with linguistics, human sciences or social sciences background wanting to study the role of management of multilinguality and text encoding, especially with reference to Scandinavian languages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Epigenetic Data Integrated in a Big Data Approach to Unravel Novel Pathzays of CV Risk independent of classical CVD Risk Factors in Women.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Epigenetic mechanisms might be involved in linking environmental and lifestyle factors and CVD development. Several studies suggest that changes in DNA methylation contribute to the regulation of biological processes underlying CVD, such as atherosclerosis, hypertension and inflammation. The recent increased digitalization, collection and storage of vast quantities of data in combination with advances in data science, has opened up a new era of big data. Although these approaches are gradually implemented in a number of clinical settings, they still lack the integration with environmental individual data, strongly affecting several multifactorial diseases such as cardiovascular disease (CVD). Classical risk factor approaches still fail in correctly estimating CVD risk in women compared to men, therefore there is a need for novel strategies to identify signs of reversible early disease or disease risk factors in this population.We plan to generate and analyse epigenetic data in the context of a very large number of environmental and lifestyle variables (big data) in a group of women and men with traditional CVD risk factors (and age-matched controls) selected from the MOLI-SANI cohort. With this approach we hope to shed light into the controversial aspects of CVD prediction and prevention in women, independently of traditional CV risk factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel 1D photonic metal oxide nanostructures for early stage cancer detection' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project CanBioSe targeted to strengthen international and intersectoral collaboration, sharing new ideas andknowledge transfer from research to market and vice versa in the field of nanostructured metal oxide optical biosensors forcancer cells detection. Interdisciplinary project research and innovation goals are targeted to develop a new portable tool forearly stage cancer detection which can solve on of important health challenges in EU society. One dimensional (1D) polimernanofibers will be deposited by electrospinning technique. Photonic nanomaterials, based on metal oxide basednanostructures (ZnO, ZnO/Al2O3 nanolaminates, Au/ZnO and ZnO/Au) will coat the 1D nanofibers. Metal oxides and Aunanoparticles will be deposited with Atomic Layer Deposition (ALD) and electrophoresis, respectively. Bioselective layer willbe formed by immobilization of specific antibodies on the biosensor surface. Photoluminescence and optical spectroscopywill be used for recording of the biosensor signal. Biosensor testing will be performed on cancer cells (human chroniclymphocyte leukemia (CLL) leucosis and acute lymphoblastic leucosis). The biosensor will be integrated with microfluidicsystem in order to minimize dimensions and simplify the use of the detection system.The project partners will provide research and training activities in the fields of nanotechnology, surface functionalization,bioengineering, microfluidics and biosensor testing, market analysis and commercialization. Provided research andmanagement training to experienced researchers and early stage researchers will strengthen their personal skills and CVsvia new scientific papers and conference theses and strengthen a development of EU research human resources. Longlasting collaboration between partners, based on co-supe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Internet of Things Initiative'.

assistant: **Objectives**

Internet of Things (IoT) is one of the most important areas of a Future Internet with significant potential to positively impact European economy and society. The current IoT research community is however highly fragmented, featuring diverging approaches and technologies. This inevitably leads to a lack of coherency that hinders the realisation of an interoperable IoT, preventing the IoT to achieve its full potential.The IoT initiative (IoT-i) brings together key actors from all relevant but currently fragmented IoT communities in Europe to work jointly towards a common vision of the Internet of Things. It represents the first serious attempt in building a unified IoT community in Europe, going across boundaries of disparate technology sectors, in order to create a joint European strategic vision of the Internet of Things and aligning this vision with the current developments on the Future Internet.The IoT-i pursues the achievement of the following strategic objectives:  1) Creating a joint strategic and technical vision for the IoT in Europe that encompasses the currently fragmented sectors of the IoT domain holistically. 2) Contribute to the creation of an economically sustainable and socially acceptable environment in Europe for IoT technologies and respective R&D activities. 3) Creating an environment that favours international adoption of European IoT technology.To achieve the objectives the project will utilize and implement a range of instruments. Most notably is the creation of an international IoT forum that will be used as a global platform to bring together key international stakeholders from all technology and application areas relevant to IoT. Other tangible outcomes are a converged reference model for IoT aligned with other areas of the Future Internet, sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulation of Rho proteins by mechanical forces in the vascular system' to be submitted under Seventh Framework.

assistant: **Abstract**

As molecular links between mechanosensors and the regulation of cellular processes Rho proteins have a critical position in mechanotransduction. Interestingly during cardiovascular disease (CVD) involving aberrant hemodynamic forces Rho proteins are activated. How do mechanical forces regulate Rho proteins? How do they contribute to the mechanical adaptation of the cell? And How is this mechanism altered during CVD? To answer these questions we have designed a proposal in two phases with interdisciplinary approaches including biochemical assays, three dimensional force microscopy (3DFM) and in vivo analysis. 1.Outgoing phase: To determine how mechanical forces activate Rho proteins and to evaluate the involvement of Rho proteins during the mechanical adaptation to force. We will identify the mechanism of Rho proteins activation using an innovative biochemical assay developed in the host lab and we will evaluate their involvement in mechanical adaptation of the cell using 3DFM. 2.Return phase: To evaluate the pathophysiological relevance of the mechanisms identified during the first phase. We will determine the cellular functions downstream of the regulators identified during phase 1 and we will investigate their activities in two animal models of altered hemodynamic forces by using the small animal physiology core facility available in the return host. The proposed project will yield new insights in different areas of life science from fundamental cell biology to potential identification of new therapeutic targets. First the anticipated results will contribute to better understand how the cells modify their mechanical properties in response to force. This crucial mechanism is central in many aspects of biology. We will also evaluate the modulation of Rho regulators in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimization of energy dissipation devices, rolling systems and hydraulic couplers for reducing seismic risk to structures and industrial facilities' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content Earthquake protection of important buildings and bridges, potentially hazardous industrial plant and vital equipment is of key importance on both safety and economic grounds. Constructors, plant designers and equipment manufacturers have the need for additional techniques for providing that protection. Manufacturers, developers and end-users of anti-seismic devices have identified methods, which together have the potential significantly to augment the options currently available and therefore greatly increase the possibility that economic seismic protection can be provided to any particular structure, plant or equipment. Three types of device -elasto-plastic, viscous dampers, hydraulic couplers - require significant optimisation of existing technology and fabrication methods. Others - viscoelastic dampers, and particularly rolling-ball systems - need even more extensive development and evaluation; the last, however, may be effective for light, complex structures which are otherwise difficult to protect. The principle objectives are to optimise the design manufacture and performance of the five types of device mentioned, to fabricate prototypes and to evaluate the benefits of the devices to design of safe structures. The properties of the devices will be characterised, and theoretical models produced. Structure mock-ups, in particular civil buildings, sections of chemical or other industrial plant (liquefied natural gas tank and curved pipeline segments), and equipment (in particular HV electrical switchgear) protected by the most appropriate type of device will be tested under seismic loadings and the performance of the devices assessed. Comparison with predictions of structural response using a theoretical model of the particular device will enab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Macroevolutionary Rates by Integrating Phylogenomics and Ancestral character States - A study on Neotropical butterfly evolution.'.

assistant: **Concept**

Delving into the factors and processes driving biodiversity is essential to understand the potential consequences of environmental changes in species-rich and vulnerable ecosystems. MARIPOSAS (Macroevolutionary Rates by Integrating Phylogenomics and Ancestral character States – Mariposas is also the Spanish translation for butterflies) aims to unveil the macroevolutionary mechanisms governing diversification and geographical distribution of two butterfly families, Hesperiidae and Nymphalidae, across tropical America's biomes. Through a multidisciplinary approach that integrates genomics, ecology, biogeography, palaeoenvironmental reconstructions and advanced bioinformatics, this project will disentangle the components of insect evolution in tropical environments. The research is (1) timely, since the tempo and mode of arthropod radiation in the Neotropics remains largely unexplored at high taxonomic levels, (2) original, as it aims to establish a novel direction in insect macroevolutionary research applying state-of-the-art methods (e.g., high-throughput sequencing) to study tropical biodiversity dynamics, and (3) innovative, by studying insect evolution in a multi-layer approach that will allow to comprehensively understand the ecological and evolutionary processes driving Neotropical insect diversity. The project will be enriched and highly benefited by merging my solid background in tropical insect diversification with the outstanding expertise in Neotropical biogeography and biodiversity dynamics at Prof. Alexandre Antonelli's research group (University of Gothenburg). This post-doc will ensure the best possible career opportunities for me as I will receive substantial training in cutting-edge approaches, largely expand my collaborative network, and gain the fundame
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'City based interventions to stimulate active movement for health' in the context of a Horizon Europe call.

assistant: **Objectives**

CITY-MOVE adapts and implements the WHO Global Action Plan on Physical Activity (GAPPA) in six cities across three continents and develops a cross-contextual evaluation framework for transferability and scalability. Physical activity is a key behavior to reduce the NCD burden, including protecting against cancers and type 2 diabetes. There are many evidence-based interventions for cities to promote physical activity, yet they remain under-implemented, with a whole-of-system approach particularly lacking, and often fail to target the least active or vulnerable groups. Knowledge gaps are: a) how to adapt, b) successfully implement, and c) evaluate interventions, and d) how to transfer lessons to other interventions, target groups and contexts. In partnership with the cities, we identified interventions targeting individuals across the life course, particularly vulnerable and least active groups, aligned with the GAPPA domains of active people, societies, environments and systems. CITY-MOVE will: 1) Develop a city-GAPPA Theory of Change and operationalise assessment measures; 2) Adapt city-GAPPA to six cities, engaging stakeholders in each context; 3) Support cities in successful implementation through action research in living labs; 4) Assess reach, adoption, feasibility, fidelity, and sustainability of selected interventions in each city; 5) Improve the development and utilisation of routinely collected data to support successful implementation; 6) Generate cross-contextual evidence on implementation, evaluation and scalability through multi-criteria decision assessment for 12 interventions in six cities; and 7) Generate global capacity through regional Communities of Practice. CITY-MOVE results lead to increased physical activity by target populations, contributing to r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International Cancer Research Fellowships' (ICARE).

assistant: **Concept**

The Italian Association for Cancer Research (AIRC), the Italian leading charity providing about 40% of all research funds invested in cancer research in Italy, proposes to award 56 fellowship/years for international mobility in two yearly calls for proposals. The fellowships will be awarded, started and concluded in the 4 years of the iCARE duration.iCARE will address the following issues:- International mobility. AIRC aims at promoting the flow of cancer researchers to and from Europe with Outgoing, Incoming and Reintegration Fellowships.- Individual-driven mobility. Fellows will be able to choose freely their destination (country, hosting institution and laboratory).- Fields of research. With a completely bottom-up approach, fellows will propose the their own research topic, with a clear focus on cancer.- Working conditions. iCARE will improve the fellows conditions by awarding full employments contracts, including social security contributions.- Training. Fellows will have the opportunity of widening their competences and expertise by receiving complementary skills trainings.- Selection process. AIRC will employ its fair and transparent peer review process to select only the most competitive and meritorious applications.- Gender balance. When equally qualified, researchers will be selected in order to achieve an optimal gender balance among the awardees.- Geographic distribution. When equally qualified, researchers from less favoured countries will be selected.The expected outcomes of this fellowship programme will coincide with the main objectives of the European Research Area (ERA). With this initiative AIRC will increase the flow of competent researchers through Europe, improve their employment conditions and enhance their professional advancement. Ultimately, iCA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Developing Geroprotectors to Prevent Polymorbidity' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Advancing age is the major risk factor for disability and illness, including cardiovascular, metabolic and neu-rodegenerative disease and cancer. The increasing incidence of older people in European countries is posing major medical, social and economic challenges, and there is an urgent need to find ways of compressing late-life morbidity. Ageing has proved malleable to genetic and pharmacological interventions in laboratory animals, and at least some of the mechanisms are conserved over large evolutionary distances. Reduced activity of the nutrient-sensing insulin/insulin-like growth factor/TOR signalling network can increase health and combat ageing-related disease in laboratory animals, with increasing evidence of its importance in human ageing. There is thus a prospect for pharmacological intervention to prevent more than one ageing-related condition, rather than tackling diseases one by one and as they arise. The aim of this research programme is to evaluate the potential for pharmacological prevention of ageing-related decline in humans with a polypill targeting the nutrient-sensing network. We find that three licensed drugs, lithium, rapamycin and trametinib, act independently, at different nodes in the network, to increase lifespan in the fruitfly Drosophila, implying that the network controls more than one underlying mechanism of ageing, and that a polypill of these drugs could be particularly effective. We shall test this idea in mice, and assess the underlying mechanisms in Drosophila and mice. We have found that suppression of the Ras signalling branch of the network, which has a well known role in human cancer, can extend lifespan in both the fruitfly Drosophila and mice, and we shall assess its role in humans. Interventions that ameliorate ageing often ha