RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advances in Numerical and Analytical tools for DEtached flow prediction' under Seventh Framework.

assistant: **Concept**

The present project is based on existing collaborations in different national and international projects,  a common research interest toward fluid dynamics applied to industrial problems and existing, although immature, common training programs between the partners. We all partners agree that the current skills of science graduates in the technologies covered by this project are still insufficient. The project also tries to address the shortage of scientists and engineers in Europe in the next future by offering an attractive plan of training and research, with strong  colaboration between industry and academia.From a technical point of view, the training is focused on acquiring awareness of new potential technologies, as well as, new capabilities to be implemented within the design process. Intention is to extend the range of simulation available today, both in physics understanding and new technologies coming from the consortium. Direct impact is expected within methods that could support on the complicated analysis of flow separation (by introducing new techniques that provide insight about the stability of a given design), noise generation (early simulation capabilities based on current technologies in use), novel simulation techniques (that will reduce the design loop cost by reduction of resources needed to perform the same simulation),  solution quality increase (by improving the mesh generation quality assessment).The complete research and training program for all researchers recruited inside the network is based on the Network-Wide Training approach (training through carrying out individual research projects) and complemented by Internal Network Training (secondments, advanced courses, workshops, open international competitions, training by internet)  and Local
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovative modular vehicle concepts for an integrated European railway system' (MODTRAIN), addressing dissemination and exploitation.

assistant: **Impact**

To meet the exacting performance improvements identified in the business scenarios listed in the ERRAC Strategic Rail Research Agenda as overall transport growth (40% for passengers to 7500 billion passenger/km is expected in 2020) and transport demand increase (passenger market share will almost double and market volume will triple in comparison to 2000),reliable,affordable and attractive interoperable rolling stock must become the norm for use on European networks.Within the frame of the two Railway Packages,the High Speed and Conventional Rail Directives are being brought into effect by the publication of Technical Standards for Interoperability (TSIs) and validated via new and improved voluntary norms.The practical implementation of interoperability via these changes often lags considerably behind the legal framework. To avoid the risk of each new train being the subject of independent interpretations of the requirements and built from unproven prototype sub-assemblies interoperable constituents must be defined,validated and promoted at European industry level.That's why,the main European railways systems manufacturers (Ansaldo Breda, Alstom, Siemens and Bombardier),sub-systems suppliers (Knorr-Bremse, Deuta Werke, Lucchini,...) railways operators (SNCF, DB, FS) and Professional associations as UNIFE,UIC,VBD,FIF,ANIE and RIA have decided to join their efforts with high skilled research centres to reach this objective. Initially,the MODTRAIN studies will concentrate on fixed formation passenger trains and Universal Locomotives capable of 200 km/h and more,but as work advances it is hoped to extend this scope to embrace all rolling stock likely to operate over the high speed and conventional interoperable networks. As a starting point the MODTRAIN Integrated Project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Clinopyroxene As a Quantitative Window Into Pre-Eruptive Magma Storage Conditions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The pre-eruptive pressure (depth) of magma storage beneath a volcano modulates the eruptive behaviour observed at the surface. Pressure controls the physical properties of magma such as the crystallinity via pressure-sensitive phase equilibria as well as the concentration of dissolved volatiles within the melt. Such parameters drastically affect how violently the volcano will erupt, and by extension the resultant societal and economic impact. However, it is increasingly apparent that one of the main ways that we recover pre-eruptive pressure from magmas, namely the link between the major element chemistry of the magmatic mineral clinopyroxene and pressure, is subject to large uncertainty. CANVAS will improve our understanding of the coupling between the chemical-structural variability of clinopyroxene and the crystallisation pressure. We will run a series of equilibrium crystallisation experiments on an Icelandic basalt starting material at atmospheric (1 atmosphere) and crustal (200  800 megapascals) pressures, employing thermal methods to grow large (>30 m) crystals. Experimental clinopyroxenes will be measured for major elements using electron probe microanalyser. The same crystals will be subject to synchrotron X-ray microdiffraction to establish crystal structure and electron density, refining the true (observed) distribution of cations within the crystal lattice. The true composition of natural clinopyroxene has been previously shown to differ from assumed chemistry. In doing so, we will perform the first large, systematic study of clinopyroxene at crustal pressures by synchrotron to our knowledge. This approach will allow us to robustly isolate experimental pressure effects from temperature and melt composition, refining the observable chemical and physical respo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechatronic upgrade & wheelchair integration of the service manipulator the arm' under Fifth Framework.

assistant: **Concept**

The Arm, a product of the main propose, is a wheelchair-mounted rnanipulator that serves disabled who lack hand and arm function. Using the Arm, the end-users regain a certain degree of their independence, as they are enabled toper form daily tasks on their own. Arm and users consider this of great importance for their lives. The project concerns the upgrade of the Arm and its gripper based on the users' demands. The goal of the project is to deliver a new product improving accuracy to 0.5mm, weight to 12kg, payload to o.k. operating noise to 40dB, adding force control feedback on a modular gripper, and achieving a reduction of the price to 17500Euros. Achieving the goalproposers will sell a unique product, and the end-users will get an innovative aid that would drastically improve their quality of life. Exact Dynamics BV, aims the redesign of the Arm mechanic drives, drive electronics and sensors. Neon Ltd, targets the development of the modular force feedback gripper. Experienced RTD performers will enhance the consortium. The project is of highest strategic importance to both Sees, as the gripper and the manipulator are their key products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Genomic instability and radiation-induced cancer' (RADINSTAB) under Fifth Framework.

assistant: **Objectives**

The recent discovery of radiation-induced genomic instability has raised concern for its implication in the radiation protection of the public, especially, quantification of human risk for low doses and high LET exposure. The role of radiation-induced genomic instability in radiation carcinogenesis will be studied with animal models and mechanistic investigations of induction and transmission. Genes and genome regions involved will be studied and the basis of individual susceptibility investigated. The relationship of genomic instability endpoints to radiation dose, dose rate and quality will be determined. The proposal brings together all major European laboratories involved in the discovery, characterization and mechanistic investigation of radiation-induced genomic instability. A state of the art working document on the relevance of genomic instability for cancer risk assessment will be prepared for the use of European decision makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Design and Engineering Next-Generation Nanopore Devices for Bioplymer Analysis' (DeE-Nano) targeting Horizon 2020.

assistant: **Abstract**

Nanopores have emerged in the past few years as a promising analytical technique. The basic concept of nanopore sensing is to apply a potential across individual nanoscale pores and observe the disruption of the ionic flow caused by single molecules entering the pore. Ionic currents through protein pores have been successful at recognizing tiny differences in molecules in solution. Most notably, arrays of thousands of nanopores integrated in low-cost and portable devices are now capable of sequencing DNA at the single-molecule level. The main challenge of nanopore sensing is the inability of controlling the protein pore diameter and geometry, which determines the signal and enables selectivity based on physical size.The aim of this proposal is to design a new generation of protein nanopores that will take on the next grand challenge in nanopore sensing, that is the sequence identification of single proteins. In order to sequence proteins, the designed nanopores must: unfold a target protein, control the speed of its transit across the nanopore and recognize individual amino acids. Our approach is to design a transmembrane molecular machine that will unfold target proteins and feed the linearize polypeptide through the nanopore where single amino acids will be recognized by modulations of the nanopore current.The specific objectives are: i) Develop chemical and biotechnological methods to design synthetic protein-based pores ii) To precisely attach the unfolding machine to a nanoporeiii) To genetically engineer the nanopore for optimal amino acid recognitionOur nanopore devices will be used to develop the first technology to sequence single proteins. Compared to the state of the art ‘shotgun proteomics’, the nanopore approach will allow long polypeptide reads, recognitio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Rapid Biosensor for the Detection of Mycotoxin in Wheat'.

assistant: **Innovation**

Mycotoxins are naturally occurring secondary metabolites produced by certain moulds/fungi as a result of their organic processes. Unfortunately, most mycotoxins are known to hazardously contaminate crops and consequently animal feeds and animal products, causing significant economic losses associated with their impact on animal and human health, animal productivity and domestic and international trade. While the economic effects are not easily calculated due to the several participants in the grain sector, European Union is setting stricter and stricter limits of mycotoxin concentrations. Deoxynivalenol also known as DON or vomitoxin is one of about 150 related compounds known as the trichothecenes that are formed by a number of species of Fusarium and some other fungi. It is nearly always formed before harvest when crops are invaded by certain species of Fusarium such as F. graminearum and F. culmorum. Our goal would be twofold: -developing a new sampling technique guaranteeing a 95% bulk transparency, -adapting a biosensor technology for the detection of deoxynivalenol. The electrochemical detection was selected as the amperometric sensor technology using a special biorecognitive layer proved to be the most reliable, low-cost method to be used in an on-site operating device. Our proposed solution will provide an easy-to-use, environmentally friendly, continuously operating system to fight against the mycotoxin infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single-molecule tracking for live-cell protein synthesis kinetics' under Horizon 2020.

assistant: **Concept**

This project aims to map the determinants of efficient synthesis, folding, and targeting of proteins in living bacterial cells, and to understand how antibiotic drugs inhibit these events. Our findings will be used to form a quantitative description of how the mRNA sequence ultimately determines how, where, and when a polypeptide should fold, which will help to design better E. coli-based production systems for recombinant proteins; both protein folding and targeting are currently severe bottlenecks. Further, by studying the effect of clinically relevant antibiotic drugs directly on ongoing protein synthesis, we will learn how the inhibitory action on the molecular level is translated into the response on cell and population level. This knowledge will help to improve the use of current drugs, as well as to provide clues regarding how new drugs should be designed.To reach our goals, we will use and further develop our recently published fluorescence-based experimental and analytical system for live-cell single-molecule analysis of protein synthesis kinetics. Particularly, we will develop orthogonal translation systems to measure protein synthesis kinetics on defined mRNAs in an unperturbed cell background. We will also label and study key components of the universal pathway for Signal Recognition Particle-mediated cotranslational targeting of peptides to the membrane-bound peptide translocation complexes. In these applications we use small organic dyes for site-specific labeling of molecules, which allow recording of long diffusion trajectories inside cells. These trajectories are then fed to our machine-learning algorithms to deduce the binding kinetics.With an increasing demand for therapeutic proteins, such as monoclonal antibodies for cancer treatment, there is an ur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A people-centred approach through Self-Management and Reciprocal learning for the prevention and management of Type-2-Diabetes' under Horizon 2020.

assistant: **Concept**

Background:Type 2 diabetes mellitus (T2DM) and pre-diabetes contribute increasingly to the global burden of disease with the health systems struggling to effectively manage prevention and control. This necessitates contextually appropriate, policy relevant solutions with high scale-up potential. The study is built on a consortium experienced in implementation and cross-cultural translation of disease prevention and management. We aim to strengthen capacity for T2DM care including prevention in high-risk population, through proven strategies like task shifting to community health workers, and expanding care networks through community-based peer support groups.Methods: A phased, participatory approach with built-in on-going policy dialogue will be used for implementing and testing a complex intervention in three countries representing low-, middle- and high-income settings: rural Uganda, urban South Africa and vulnerable immigrant populations in urban Sweden. These actions will follow an iterative process with modifications and improvements within and between the stages of formative research to implementation and evaluation. The testing will be conducted with a controlled design in two arms, a facility-only strategy vs. a combined facility and community strategy evaluated in terms of health systems, disease-related and equity outcomes. Outcomes:The study has a strong social innovations component that will leverage existing networks and platforms, to empower patients, their families and communities through the self-management approach. It will embed research into policy and practice from the beginning; and enable cross-lessons from other chronic conditions and reciprocal learning.  It will re-introduce the essential but ‘missing’ community component still existing in low-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Forest energy - A solution for the future power needs' (FORENERGY), addressing dissemination and exploitation.

assistant: **Impact**

To follow the Kyoto agreement and the EU White paper, effective global actions are required. The only way to significantly improve the use of renewable energy in the short and medium time span is the utilisation of biomass. Other renewable energy sources (like solar and wind power) cannot contribute to any significant change in total energy consumption. This proposal creates a project in which the complete chain of renewable biomass energy source is developed and brought to the competitive level for the first time ever by utilising the best resources available.The main objectives of the project are to:- conduct high level research on the development of the renewable and clean bio-energy technology- develop the complete energy chain from the forest to the consumer- develop an energy system producing renewable energy to the market price (fuel price <8Mwh)- develop an CO2 emission neutral energy system- keep other emissions at a lower level than the regulation require.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Co-ordination of scientific activities towards elaboration of common strategy for environmental protection and sustainable management in Syr Darya River Basin, in Uzbekistan and Kazakhstan'.

assistant: **Objectives**

The project is designed to consolidate complex and fundamental information and co-operation in fields of Syr Darya River Basin investigation. The investigation and monitoring of the Syr Darya River Basin is currently carried out by a number of institutions from Kazakhstan and Uzbekistan. They are either studying individual industrial objects or are dealing with narrow and strictly specialized ecological problems.These investigations are being carried out without any coordinator because of estrangement of the investigations and a shortage of funds. In the former USSR, a high percentage of river water resources were used for irrigation. Such agricultural policy together with the usage of huge amount of pesticides has resulted in soil salinization and contamination with different chemical substances, which resulted not only in crop yield, but also affected biodiversity and human health.The realization of this project is based on the work of scientific teams from 4 countries and will provide multidisciplinary and comprehensive ecosystem studies of the Syr Darya River Basin. The project proposes coordination of scientific activities (changes in landscapes, pollution, biodiversity, restoration and agricultural implications) towards protection and sustainable management in different habitat types in the arid and semi-arid zones. The authors will examine how land-use transformations of this region have affected the ecological processes in several agricultural, natural and industrial areas of Kazakhstan and Uzbekistan.The principle objectives of this project are:1. to develop procedures for the coordination of all pro-ecological activities as well as for development of ecological education and knowledge of Uzbek and Kazakh societies2. to propose practical tools to help science a