RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control of bacteriophage development in lactic acid bacteria: towards a rational solution to a major problem of food fermentation' (1994-1998).

assistant: **Concept**

A variety of cheeses, meats and vegetables are fermented using lactic acid bacteria (LAB). These fermentation processes, largely used in Europe, are highly susceptible to bacteriophage (phage) attack. This leads to considerable turmoil in the context of tight manufacturing schedules and interferes with ensuring consistently high product quality, with the consequent negative effect on the economics of the manufacturing process. To face this problem, improved strains should be constructed, by genetic manipulation of the phage-resistance capacity of industrial strains with otherwise excellent cheese-making properties. This could be achieved either by using natural phage defense mechanisms or by designing new defence strategies directed against key steps of the phage growth cycle. To construct highly resistant strains for a long term efficient control of fermentation, we propose to: i) Design new phage defence strategies. A better knowledge of phage biology would allow to abolish phage development either by preventing some key steps of phage growth, or by using phage regulatory circuits to control expression of toxic genes and to induce premature death of infected cells. We shall characterize gene functions essential to phage development and carry out studies of the regulation of the different steps of phage development. Lactococcal phages of two main species of industrial concern will be studied. Defense mechanisms preventing phage replication or inducing cell death will be designed. The background knowledge acquired on lactococcal phages will be adapted to those of other phage species: Streptococcus thermophilus, Lactobacillus helveticus and Lactobacillus casei. ii) Increase the efficiency of natural phage defence mechanisms. To protect strains efficiently against a large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hyperconnected simulation ecosystem supporting probabilistic design and predictive manufacturing of next generation aircraft structures' in the context of a Horizon Europe call.

assistant: **Objectives**

CAELESTIS will develop an end-to-end Interoperable Simulation Ecosystem (ISE) that will perform multidirectional dataflow across the aircraft value chain linking product design and distributed engineering teams´ CAD-CAE tools, to accelerate the design and engineering optimization of disruptive aircraft and engine configurations, ensuring their manufacturability from the design conceptualization. CAELESTIS ecosystem will be developed to integrate, interoperate, and autonomously execute simulation workflows involving a variety of state-of-the-art simulation tools to support the multi-disciplinary design, optimisation as well as uncertainty quantification and propagation across the design and manufacturing chain. The ecosystem will be boosted by HPC infrastructures to massively execute predictions and deliver optimized design and engineering outputs at realistic-time scales. In this regard, high-fidelity model-based digital twins with unprecedented level of detail and covering several production stages and manufacturing deviations will be developed and interconnected. Those will be linked to machine learning tools adapted to HPC simulation outputs to improve detection of manufacturing flaws based on a probabilistic approach to quantify uncertainties and their propagation and influence on structural integrity, as well as identify design for manufacturing interdependencies to provide optimized product topologies. From manufacturing point of view, HPC simulations will be made available at manufacturing shopfloor as reduced order models in online monitoring edge computing devices, to support i) product performance prediction based on detected defects on real time and ii) informed corrective actions to minimize and compensate their effect. Overall, CAELESTIS ISE will contribute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The seventh symposium on bacterial genetics and ecology' in the context of a Fifth Framework call.

assistant: **Objectives**

BAGECO-7 will present the most recent research in the interdisciplinary context of bacterial genetics and microbial ecology. Focus will be on the application and implementation of novel techniques and basic knowledge on genomic and bio informatics on environmental microbiology and biotechnology. It has a scientific committee with members from 10 European countries and most of the participants come from EU and associated countries. BAGECO-7 will take place in Bergen, Norway, 15-19 June 2002 with approximately 200 participants and 8 invited speakers. Main topics are related to environmental biotechnology incl. use of GMO and risk assessment, molecular approaches to analyse bacterial community structure and function. Phage and plastid molecular ecology and horizontal gene transfer. The symposium should stimulate contact, improve research quality and provide additional value by increasing European co-operation in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of transposable elements in plants and impact on genome evolution' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Transposable elements (TEs) are mobile genetic elements present in virtually all genomes. They make up nearly half of the total amount of DNA in plant genomes, so definition of their influence on genome structure and gene expression is of clear significance to the understanding of global genome regulation and phenotype variations. The movement of TEs within genomes can generate mutations by interrupting or modifying the regulation or the coding capacity of genes, and recombination between transposon copies located at different chromosomal regions can generate chromosomal rearrangements. Work done over the last few years has confirmed that TEs are at the origin of an important number of genes and regulatory sequences and that transposition has been essential for the evolution of complex genomes. They also have an important role in chromatin structure and function. Miniature Inverted Repeat Transposable Elements (MITEs) constitute a particular type of mobile elements that are present in high copy numbers in genomes. The objective of the project is to study the impact of MITEs in the regulation of nearby genes and to analyze their possible role as genome organizer elements. To this end, we will start applying dedicated bioinformatic tools to complete the Arabidopsis MITE landscape, and we will analyze the epigenetic marks associated to these elements. In a second stage of the project we will analyze their influence on the expression of neighboring genes taking advantage of the variability of MITE insertions in different Arabidopsis ecotypes. Finally, we will analyze the possible role of selected MITE families as genome organizers, by studying their localization in chromosomes by fluorescent in situ hybridization (FISH) analysis and by chromosome conformation capture approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient photobioreactor for the production of algae-based chemical resources' (LAURA), addressing dissemination and exploitation.

assistant: **Impact**

The overall goal of Cleantech Innovations (CTI) is the upscaling of an innovative photobioreactor (a reactor to grow algae), that exceeds current alternatives on both efficiency and cost of operation, providing a competitive alternative to produce high-end bio-based components for the food industry. By optimizing the light exposure and liquid flow rate, the technology’s efficiency is expected to double its efficiency compared to current solutions.Competing companies producing algae are encountering issues in using the wrong technologies, and producing the wrong output (wrong market). CTI’s revolutionary LAURA platform has proven a solution to the technical and operational disadvantages that are encountered in current production setups, whilst focussing on high value, high margin output products, i.e. for the food and pharma industries.The company’s goal is to offer a commercially viable reactor that can (competitively) grow algae, which can be used as a sustainable resource in the production of valuable, natural ingredients, specifically targeting the production of i.e. special proteins, omega-3 and omega-6 fatty acids, pigments, anti-oxidants, flavour enhancers, and precursors for medicines. The objective for this Phase 1 feasibility study is to assess an EU roll-out plan and business plan determining for what specific end-products the LAURA platform should be launched for optimal scale-up..
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Fast and Reliable Technology for Soil Inspection in Contaminated Sites with Machinery Condition Monitoring' in the context of a Seventh Framework call.

assistant: **Objectives**

The overall aim of the SOIMON project is to develop a more advanced in-situ investigation method for identifying and characterising pollution in contaminated soil. This will be achieved by integrating sophisticated sensors (e.g. micro-chips, electrochemical sensors, spectrometry, and optical sensors) into a solid probe intended to drive down through the soil matrix to perform continuous or semi-continuous measurements.The sensor measurements provide improved and more precise data input through the chemometric analysis as basis for better decision making. Furthermore, the investigation method will be easier and quicker to use, and hence also less costly than current SOA investigation methods. The reason for this is the operation time that will be significantly reduced. In fact the drilling machine will operate at the speed of 0.5m/s and the different sensors will be adapted to offer the required sensitivity and reactivity at such high drilling speed.Tool wear presented high level of challenge in this area which affects the operation time and the efficiency of the investigation, and failure monitoring has raised quite a lot of interest amongst researchers and has consequently been studied in a number of research projects by research organisations. The reason for this interest is that drilling tool condition monitoring is considered important as it can affect the efficiency of the soil sensing process during drilling.The SOIMON project will develop an in-situ soil sensing system that is deployed in a sonic drill machine. The complete system/ bore pipes are going to be equipped with condition monitoring sensors in order to enhance the time, cost and reliability of the soil monitoring process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BIOtechnological processes based on microbial platforms for the CONversion of CO2 from ironsteel industry into commodities for chemicals and plastics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main objective of BIOCON-CO2 is to develop and validate in industrially relevant environment a flexible platform to biologically transform CO2 into added-value chemicals and plastics. The versatility and flexibility of the platform, based on 3 main stages (CO2 solubilization, bioprocess and downstream) will be proved by developing several technologies and strategies for each stage that will be combined as puzzle pieces. BIOCON-CO2 will develop 4 MCFs based on low-energy biotechnological processes using CO2 from iron&steel industry as a direct feedstockto produce 4 commodities with application in chemicals and plastics sectors using 3 different biological systems: anaerobic microorganisms (C3-C6 alcohols by Clostridia), aerobic microorganisms (3-hydroxypropionic acid by Cupriavidus necator) and enzymes (formic acid by recombinant resting E. coli cells and lactic acid by multi-enzymatic system). The technologic, socio-economic and environmental feasibility of the processes will be assessed to ensure their future industrial implementation, replicability and transfer to other CO2 sources, such as gas streams from cement and electricity generation industries. BIOCON-CO2 will overcome the current challenges of the industrial scale implementation of the biotechnologies routes for CO2 reuse by developing engineered enzymes, immobilization in nanomaterials, genetic and metabolic approaches, engineered carbonic anhydrases, pressurized fermentation, trickle bed reactor using advanced materials and electrofermentation. Theproject aims to capture at least 4% of the total market share at medium term (1.4Mtonnes CO2/year) and 10% at long term (3.5Mtonnes CO2/year) contributing to reduce EU dependency from fuel oils and support the EU leadershipin CO2 reuse technologies. Policy rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Kaizen information system and management support' (KISS).

assistant: **Concept**

Following the Japanese lead, manufacturing organisations world-wide, have been investing huge efforts in promoting and implementing continuous improvement methodologies (Kaizen). Kaizen aims at systematically eliminating any kind of waste, through empowering workers at all levels and involving them in the permanent search for new methods of work, improved ways of designing, producing, monitoring, managing etc.A key issue in implementing Kaizen successfully, is the creation of a continuous improvement culture within the workforce, at all levels, and of an appropriate environment that favours & encourages people's involvement, empowerment and commitment. Equally important is the availability of appropriate tools to manage Kaizen, to record performance, analyse problems, evaluate solutions, track achievements etc.KISS aims to make the full scale implementation of Kaizen more cost-effective, in both large organisations and SMEs. KISS will- consolidate a Kaizen implementation and management methodology (the KISS methodology). A KISS handbook will be produced addressing all key issues from Kaizen take-up procedure to organisation & management practices, working best practices, standards and results achieved etc.- develop, test, validate, demonstrate and exploit an innovative supporting tool (the KISS IT-infrastructure) which will build on the aforementioned methodology and address in a coherent and integrated way, needs for support at the 4 different levels of Kaizen implementation i.e. individuals, groups, sites (e.g. single factories) and enterprise (multi-site organisations). KISS will combine into a modular and integrated IT-infrastructure technologies for decision support, workflow, and communications, with specific emphasis on HCI - Human Computer Interfaces - and integ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel Out-of-Equilibrium Spectroscopy Techniques to Explore and Control Quantum Phenomena in Nanocircuits' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We plan to develop and make use of novel out-of-equilibrium spectroscopy techniques that give access to energy transfers inelectronic nanocircuits. The unveiled information will be used to investigate promising quantum phenomena and to explore newroutes to control the mechanisms that limit their potentialities for nanoelectronics.The proposals backbone is the spectroscopy of the fundamental electronic states energy distribution function f(E) that wedemonstrated this fall 2009: by using a quantum dot as an energy filter, we performed the first measurement of a non-equilibriumf(E) in a semiconductor nanocircuit. We plan not only to employ it, but also to develop complementary techniques which will furtherwiden our range of investigation. We anticipate this f(E) toolbox will be crucial for the rising field of out-of-equilibrium mesoscopicphysics.We will first examine through the unexplored facet of heat transport the quantum Hall effect regimes, which exhibit a large varietyof puzzling many-body quantum phenomena and are of particular interest for their metrology applications and quantum informationpotentialities. The planed experiments will be done for various out-of-equilibrium situations, which will permit us to address longstandingopen questions, such as the nature of pertinent excitations, and to test original ways to increase quantum effects.We will also perform direct energy exchange measurements to investigate the inelastic mechanisms that set the length and energyscales of coherent and out-of-equilibrium physics in nanocircuits. The novel f(E) spectroscopy will permit us to take advantage ofthe two-dimensional electron gas circuits high modularity to study many transport regimes and geometries that remain unexploredfrom this revealing viewpoint.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dimers, Markov chains and Critical Phenomena' (DMCP).

assistant: **Concept**

This project proposes a 12-month mobility of the applicant F. Toninelli from the University of Lyon 1 to the Mathematics and Physics Department of Roma Tre. The applicant will be supervised by local scientistsF. Martinelli and A. Giuliani.The scientific project focuses on the probabilistic study of dynamical and equilibrium properties of discrete random interfaces, spin models and dimer models. One of the main goals is to derive, starting from a microscopic stochastic dynamics, a macroscopic deterministic evolution (often, an anisotropic mean curvature flow) in the scaling limit. Another important issue are equilibrium fluctuations of random discrete interfaces and dimer models. The proposed research has tight links with mathematical physics, discrete geometry and rigorous quantum field theory.  Mathematical tools to be employed include Markov Chains, conformal invariance, random walks on graphs, rigorous Renormaliazation Group techniques...  More specific problems that will be attacked include:1) Dynamics and equilibrium fluctuations of random dimer coverings (perfect matchings) of bipartite graphs: theseare a central object in combinatorics and discrete geometry and can be seen as discrete interfaces. How does their geometry evolve under stochastic dynamics?  What is the dynamical consequence of the conformal invariance properties of their equilibrium fluctuations? How quickly can one sample a random perfect matching (mixing time)?2) Universality for two-dimensional statistical mechanics models. We will study the critical properties of weakly interacting dimers on the square lattice (the non-interacting case being exactly solvable). As a long-term goal, we wish to study the spin-spin correlation functions of two-dimensional, non-integrable critical Ising models.3) Dis