RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Zebrafish Regulomics for Human Health' (ZF-HEALTH), addressing dissemination and exploitation.

assistant: **Impact**

In recent years, the zebrafish has emerged as a new vertebrate model organism for biomedical research which offers a unique combination of traits: a short generation time, small size and efficient breeding procedures make it the best choice among vertebrates for forward genetic screening and small-molecule screens, including toxicology, while the transparent embryo and larva offers unique opportunities for imaging of cell movement and gene expression in a developing organism. Building on recent advances in the zebrafish field, we will conduct high-throughput phenotyping of at least a thousand regulatory genes relevant for common human diseases, by behavioural assays (for viable mutants), 3D / 4D imaging and expression profiling (including high-throughput sequencing). We will include mutants generated by TILLING and by the new zinc finger nuclease method, as well as mutants from earlier forward-genetics screens. A phenotyping effort of this scale has never been undertaken before in any vertebrate organism. Complementing the study of mutants relevant for neurological disorders, we will produce an atlas of gene expression in the brain, the most comprehensive one in a vertebrate. We will further perform a genome-wide characterisation of regulatory elements of potential disease genes by a combination of bioinformatics and transgenics. Small-molecule screening for mutant rescue or disease-relevant processes will identify candidate drugs and provide insights into gene function. Our increasing knowledge on the regulators and their interactions with regulatory targets will be integrated with knowledge at cellular and organismic level. By capitalising on the virtues of the zebrafish system, this systems biology approach to the regulome will gain unique knowledge complementing ong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced plastic encapsulation' (APE) targeting Fourth Framework.

assistant: **Abstract**

Plastic packaging technologies are now utilised not only in the encapsulation of discrete electronic components bur also in the encapsulation of high performance ULSI and VLSI circuits and microsystem components. This is primarily due to issues of cost. Alternative materials are unlikely to replace plastics for the vast majority of applications for the foreseeable future. It is increasingly evident that plastic materials are being and will continue to be used by European microelectronic and microsystems companies. At present 90% of plastic encapsulants used by European companies in the packaging of microelectronics components and microsystems are manufactured in Japan. This situation puts European companies in a very vulnerable position with regard to continuity of supply. This was clearly shown following the accident which occured some years ago at the Sumitomo plant in Japan which resulted in a shortage of appropriate encapsulant materials. It is therefore crucial that Europe develops an independent source of new advanced plastic encapsulation materials. This proposal is aimed at addressing this problem through combining the expertise of European materials and electronics companies. Recent European research projects (EU ESPRIT 5033 PLASIC and 6386 ASAP) have addressed certain issues relating to plastic packaging technologies and in particular, the requirement for high reliability packages for application specific integrated circuits (ASIC) devices. These projects were focused on the identification of reliability hazards, thermo-mechanical modelling of packages and the development of sophisticated test methods. TRIMOD (ESPRIT 6410) was concerned with the design and development of a three dimensional or vertical multichip module. However, to-date European research progr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Redesigning the Primary Sector for Maximizing Bioeconomy Development' (PRIMED), addressing dissemination and exploitation.

assistant: **Impact**

The EU has a significant amount of waste biomass available, more than 900 million tons per year, and 98% of this material ends up in landfill, incinerators, or rotting in open dumps. According to the 2023 Circularity Gap Report, the global economy is now only 7.2% circular.  The EU has great potential to convert bio-waste into bio-based products that can be used in multiple bio-applications. This revalorisation can directly support 5-10 times more employment and generate 4-9 times more added value than energy use.Circular Business Models in Bioeconomy (CBMB) face many challenges to become sustainable and profitable. Firstly, primary producers, the owners of the valuable feedstock, are often not integrated into the bioeconomy value chains, and they are often small scale and are fragmented, reducing their ability to negotiate with those higher up the value chain. The result is a suboptimal distribution of benefits and incentives. The main challenges in designing CBMB consist of: -lack of knowledge sharing and collaboration between stakeholders-need for new supply chains and logistical networks-difficult scale up of innovative technologies-understanding of the potential synergies and symbiotic relationships between sectors-overcoming poor public acceptance -complex and fragmented policy schemes, As a result of this, there is a lack of demonstrated and replicable systemic bio-solutions for the territorial deployment of the circular bioeconomy.The PRIMED ProjectPRIMED will co-create innovative forms of cooperation to integrate primary producers in novel bioeconomy value chains with a multi-actor approach. To do so, PRIMED will develop novel CBMB to produce high-value bio-based products through advanced biorefineries, and will demonstrate them in five Living Labs (LLab):PRIME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Collaboration In Training and Innovation for Growing, Evolving and Networked Societies' to be submitted under Horizon 2020.

assistant: **Abstract**

The Collaboration in Training and Innovation for Growing, Evolving and Networked Societies (CITI-GENS) Doctoral Programme at Queen’s University Belfast (QUB) will recruit and train 20 outstanding international researchers over a 60-month period. During this time, they will be transformed into a professional and skilled cohort addressing global challenges aligned to the themes of the Belfast Region City Deal innovation ecosystem: Information Technology, Advanced Manufacturing, Life Sciences and the Creative Industries. In seeking to address societal challenges in new ways and with new technologies, the CITI-GENS ESRs will engage with methodologies at the forefront of current practice in innovation, notably design thinking. Adopting the 3i approach, ESRs chosen for CITI-GENS will combine their advanced disciplinary excellence with capacity for genuinely interdisciplinary, intersectoral and international quality research involving the capacities of QUB and 25 non-HEI partners. The CITI-GENS programme has been developed on the basis that future societal challenges will emerge across rather than within economic and social sectors, requiring new technologies that are emerging or not yet developed, and which outpace developments in social structures and conventions. This is the key value of CITI-GENS: it demands that successful applicants are characterised by openness to innovation, pioneer thinking and creativity. These qualities will be nourished by means of a personalised training package for each ESR and through a range of cohort leadership and development opportunities within our award-winning Graduate School. CITI-GENS research findings will be disseminated and communicated to different stakeholders though a wide variety of channels. The proposed CITI-GENS DP will be man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Elucidating fullerene-perovskite interactions by means of First-principles calculations: Towards a rational design of low cost solar cells' under Horizon 2020.

assistant: **Concept**

Science is essential to achieve the Sustainable Development Goals implemented in the European Agenda 2030 towards the use of sustainable and clean energy. Solar energy, as the cleanest and the largest exploitable resource of energy, can potentially meet the growing requirements for the whole world’s energy needs beyond fossil fuels. Halide perovskite solar cells (PSCs) are considered as one of the most promising candidates for the next generation solar cells as their power conversion eciency (PCE) has rapidly increased up to 25.2%.With the goal to boost their commercialization, Fullerenes and derivatives have been introduced in PSC devices to improve the stability, suppress the hysteresis, and reduce the high temperatures commonly used to fabricate these devices. Developing novel fullerene derivatives for improving further the PCE and stability of PSCs is still highly desirable yet challenging. Nevertheless, it is not extensively explored the role of fullerene derivatives in PSC devices and it is still not thoroughly investigated how binding groups of fullerenes interact with perovskite surface and their influence in the electron mobility. In this project, the state-of-the-art computational chemistry will be used to understand the fullerene-perovskite interactions with the goal to rationally design new fullerene derivatives to improve the stability and efficiency of PSC devices. Density functional calculations will be employed to investigate the fullerene orientation on perovskite surfaces, binding energy, bandgap, the exciton delocalization and charge transfer in the fullerene-perovskite complexes in order to establish descriptors and correlations with the experimental data. The descriptors will be used to predict the preferred functionalization of fullerenes in order
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Holistic Approach towards Empowerment of the DiGitalization of the Energy Ecosystem through adoption of IoT solutions' (HEDGE-IoT).

assistant: **Innovation**

HEDGE-IoT proposes a novel Digital Framework which aims to deploy IoT assets at different levels of the energy system (from behind-the-meter, up to the TSO level), to add intelligence to the edge and cloud layers through advanced AI/ML tools and to bridge the cloud/edge continuum introducing federated applications governed by advanced computational orchestration solutions. The HEDGE-IoT Framework will upgrade the RES-hosting capacity of the energy systems and will unleash a previously untapped flexibility potential. It will increase the resilience of the grid, create new market opportunities and promote advances in IoT standardization, by introducing and managing a plethora of diversified, interoperable energy services over scalable and highly distributed data platforms and infrastructure. The multi-dimensional framework of HEDGE-IoT comprises the following pillars: (a) the Technology Facilitator Pillar will exploit the computational sharing by offloading applications on the grid edge, towards providing a set AI/ML federated learning and swarm computing applications; (b) the Interoperability Pillar, which leverages on leading-edge interoperable architectures, such as the Data Space architectures; (c) the Standardisation Pillar will enable all involved platforms, systems, tools and actors to seamlessly communicate and exchange data in standardized formats using widely used standards, such as SAREF, etc.; (d) the Digital Energy Ecosystem Enabling Pillar will ensure the creation of an ecosystem facilitating the increased integration of RES and characterised by resilience. Liaisons with EU initiatives for IoT and digitalisation will be established (e.g., the AIOTI) and the engagement of stakeholders will be ensured by addressing IoT ethics and cultivating trust among end-us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ERA-NET for materials research and innovation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

M-ERA.NET 2 aims at coordinating the research efforts of the participating EU Member States, Associated States and Regions as well as of selected global partners in materials research and innovation, including materials for low carbon energy technologies and related production technologies.A large network of 43 national and regional funding organisations from 23 EU Members States and Associated States and 5 countries outside Europe will implement joint calls to fund excellent innovative transnational RTD cooperation, including one call for proposals with EU co-funding and additional non-cofunded calls. Continuing the activities started under the predecessor project M-ERA.NET (2/2012-1/2016), the M-ERA.NET 2 consortium will support relevant thematic areas, such as -for example- surfaces, coatings, composites, additive manufacturing or computational materials engineering. Research on materials enabling low carbon energy technologies will be particularly highlighted as a main target of the cofunded call (Call 2016) with a view to implementing relevant parts of the Materials Roadmap Enabling Low Carbon Energy Technologies (SEC(2011)1609), and relevant objectives of the SET-Plan (COM (2009)519). The appropriate scope of the cofunded call and the additional joint calls will be defined in cooperation with relevant stakeholders including national and regional RTD communities, the EC and the EMIRI (Energy Materials Industrial Research Initiative) as well as an external Strategic Experts Group.M-ERA.NET 2 will support the whole innovation chain, clarifying for each topic the appropriate Technology Readiness Levels (TRLs) to be addressed through the transnational RTD projects. The consortium will be aware of the TRLs which are covered by the EC through Horizon 2020 topics as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Insertional mutagenesis to identify molecular mechanisms of breast cancer dormancy and metastasis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Metastatic disease is the leading cause of cancer deaths, yet our understanding of this process and therapeutic choices are extremely limited. The recent explosive development of high-throughput technologies in genomics and proteomics has begun to unravel the complexity of cancer biology, highlighting the need to approach the study of cancer from a systems biology perspective. Results of recent studies have underscored the crucial roles of the tumor microenvironment as well as cell-intrinsic processes, such as autophagy, in cancer cell survival and dissemination. These surviving cells may lay dormant or be triggered to proliferate and establish active metastatic lesions after a variable period of time. I propose an innovative project in which I will exploit the unique opportunity to dissect molecular mechanisms controlling breast cancer dormancy and metastasis employing cutting-edge technologies in the field of functional genomics. This technology includes several state-of-the-art technical advances in the fields of in vitro and in vivo modeling of tumor cell dormancy, functional forward genomics using the PiggyBac transposon-based system for insertional mutagenesis screens, next generation sequencing, advanced bioinformatics and in vitro and in vivo functional validation studies. This project will identify critical molecular processes involved in breast cancer progression and potential therapeutic targets against breast cancers at high risk for recurrence and poor prognosis. Thus, it is expected that this project will provide future translational research avenues, enhance my position to be at the forefront of cancer research and provide the opportunity to establish myself as an independent researcher following the completion of this fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Data Integrated Supply Chain Optimisation'.

assistant: **Objectives**

The objective of this project is to commercialise the Valuechain.com Ecosystem.  It is a scalable cloud-based platform that enables manufacturing businesses to optimise overall supply chain performance by connecting with supply chain partners, capturing and analysing real-time structured and unstructured data from internal and external sources, and providing multiple scenario plans to optimise individual company and overall supply chain performance through predictive analytics.Valuechain.com Ecosystem is a disruptive technology and will catalyse the creation of 4 new SME business models in high value manufacturing sectors, unlocking the potential of vertical and horizontal integrated networks of businesses that could not previously collaborate effectively as the information exchange between businesses was very fragmented and manually executed.Combining real-time knowledge of the supply chain with predictive analytics will provide unprecedented visibility and decision support for manufacturing supply chains and enable European manufacturing companies to monitor and mitigate supply chain risk, create dynamic collaborative supply chain networks by streamlining operations and reduce waste to improve global competitiveness.Successful completion of a Feasibility Study, including 22 pilot trials, has proven customer interest and price point acceptance from all tiers of the supply chain.  A technical development plan has been put together with focus on end user requirements captured.  This project will enable Valuechain.com to build on its existing commercialised supply chain collaboration and mapping solutions and secure first mover advantage. The average annual revenue generated from license rental model and aggregated procurement commissions from each client is €1,200 and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Identification of Mycobacterial Antigens as Candidates for a Subunit Vaccine Against Tuberculosis in Healthy and HIV-Infected Individuals'.

assistant: **Concept**

Tuberculosis (TB) is a global health problem which causes 3 million deaths yearly. In industrialized countries, the incidence of the disease is rising because of the AIDS epidemic and immigration from developing countries. The available vaccine, Mycobacterium bovis bacillus Calmette-Guerin, is of questionable efficacy, therefore the development of a subunit vaccine is needed. The project proposed aims at identifying immunodominant antigens as candidate components of such a vaccine, with a special focus on proteins secreted by mycobacteria during growth in vitro or produced intracellularly. It has been shown that immune CD4+T cells play a key role in immunity to M. tuberculosis in animal models. Other cell populations (natural killer cells, CD8+ and gammadelta+ T cells) also seem to be involved. Although there is evidence that T cell immunity is essential to recover from human infection too, the antigens responsible for its induction and the role of each T cell subset are still unclear. The project proposed aims at: 1) identifying M. tuberculosis, M. av um or BCG antigens involved in protective immunity. This would proceed by isolating sets of mycobacterial proteins produced in vitro (membrane, cytosol, cell wall and secretory fractions) and in vivo, inside cells, and investigating their ability to induce proliferation of human immune lymphocytes in vitro and/or release of cytokines. The final goal of this phase would be to molecularly clone them from a DNA expression library to test whether they might induce, a10ne or in combination, an immune status against M. tuberculosis in mice. 2) Dissection of human immune Iymphocyte proliferation to mycobacterial antigen fractions in vitro. The response of peripheral blood mononuclear cells from different human subjects (BCG-vacc