RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Advancement of the bilateral Partnership in scientific Research and Innovation with the Russian Federation'.

assistant: **Objectives**

The overall strategy of BILAT-RUS 2 puts the three main issues of the Capacities work programme into practice. It will provide input for the EU-Commission on the state of EU-Russian STI cooperation; contribute to coordinate research policies and programmes of European Member States, Associated Countries and the EU-Commission; enhance information collection and dissemination as regards STI between Russia and the EU; raise awareness of researchers in Russia and the EU for cooperation potentials; monitor the existing STI cooperation praxis and facilitate the implementation of a sustainable cooperation support system; analyse the Russian innovation system and provide support for enhanced implementation of R&D results; deliver a feasibility study for a common representation of European scientific institutions in Russia.One of the major success factors is the close continuous dialogue and the coordination of activities with Russian and European authorities, addressing in particular the Ministry of Education and Science of the Russian Federation (MON), responsible Ministries/Agencies in EU Member States and the EU Commission.The individual activities and tasks that are proposed in the work packages of the project cover a wide array of activities. They include general information and awareness raising activities, the maintenance of the established web-portal with data and knowledge bases on STI issues as well as a inventory and analysis of existing cooperation instruments, the preparation of three yearly analytical reports on the state of EU-Russian STI cooperation, the publication of guidelines for better implementation of R&D results, a feasibility study for a common representation of European scientific organisations in Russia, as well as a mobility grant scheme. Also, activ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optical imaging of retinal function for gene and cell therapies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

For patients suffering from inherited retinal diseases (IRDs), gene and cell therapies offer hope of preserving or restoring vision. Retinal imaging is crucial, to first phenotype patients to determine which cells are degenerated and devise an appropriate therapeutic path; then in the lab for cell therapy development, and finally back in the clinic to monitor therapeutic success in patients who have been treated with gene or cell therapy. To date, the imaging tools used in the clinic do not provide sufficient resolution for visualizing individual cells non-invasively, constituting a major roadblock for the development of gene and cell therapies. My group develops novel optical imaging tools for noninvasive cellular imaging such as full field optical coherence tomography (FFOCT), an interferometric technique, and adaptive optics ophthalmoscopy (AOO), which corrects ocular aberrations, to achieve diffraction limited resolution of in vivo retina. Recently we also devised a dynamic FFOCT method to detect metabolic contrast using intracellular organelle motion to indicate cell activity. These new noninvasive, all optical tools have the potential to provide, for the first time, simultaneous subjective and objective retinal function measurements. Here, I propose to adapt these existing optical setups based on dynamic FFOCT and AOO to allow retinal stimulation with visible light to enable functional testing of i) patients with IRDs in order to evaluate surviving cells and orient their therapy path; ii) in vitro retinal organoids derived from induced pluripotent stem cells; ii) patients being treated in our clinical centre with novel gene and cell therapies to check that vision is being successfully preserved or restored.The new imaging methods developed here will achieve quanti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'European virtual institute for speciation analysis for improvement of health, food, industry and environment'.

assistant: **Objectives**

The goal of the planned virtual institute (VI) for speciation is to develop a highly interactive network based on modern IT tools. Customers will belong to food, toy, pharmaceutical and many other industries, but also researchers, regulatory bodies, commercial and governmental laboratories and more will benefit from the VI. It will summarize and disseminate the existing knowledge on element speciation from the academic world, interact with the industrial sectors to act on a consult. and mediator basis and provide the most appropriate solutions to analytical questions. The aim of the VI is hence to give the industry access to a wide array of expertise concerning speciation measurements by bringing together all European capabilities in the sector. The VI will interact with institutional European agencies and inform about the identification of industrial needs and the scientific state-of-the-art to help improving legal regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'E3-hijacking molecular glues of RNA binding protein IGF2BP1 in ovarian cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Conventional therapeutic strategy entails developing small molecules to occupy enzymatically active or regulatory pockets of the target protein, and further inhibit its biochemical activity. However, many disease-relevant proteins, such as RAS, MYC, or b-catenin, lack manageable druggable cavities.  Bernardes and colleagues have raised a novel concept to overcome this limitation, named “molecular glues”, in which small molecules induce de-novo interactions between two proteins to modulate protein function. Molecular glues appeared as an elegant tool for targeted protein degradation, allowing simultaneous recruitment of a ubiquitin E3 ligase and the protein to be ubiquitinated. Notably, the potent anti-cancer drugs thalidomide, lenalidomide and pomalidomide (known as IMiDs for immuno-modulatory drugs), are the most prominent example of such E3-hijacking molecular glues, that exert their therapeutic effects through induced degradation of key efficacy targets.  Building on these promising observations, herein I propose a designed platform that can rationally identify synthetic chemical matter to induce selective protein dimerization and induce disease-relevant protein ubiquitination and degradation – using ubiquitin E3 ligase and RNA binding protein IGF2BP1 as a proof-of-concept in ovarian carcinoma cells. The identification of complementary interfaces for drug-induced interactions will be achieved by computational prediction, protein-protein interaction assays, and a set of novel biochemical assays, together with high-throughput screening and structure-informed chemical optimization.  This proposal will deliver a multi-layered technology to successfully design and validate novel molecular glues in a rational and generalizable way, to revolutionize current inhibitor-centri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PivotBuoy - An Advanced System for Cost-effective and Reliable Mooring, Connection, Installation & Operation of Floating Wind' (PivotBuoy) targeting Horizon 2020.

assistant: **Abstract**

The main project objective is to reduce the cost of energy (LCOE) of floating wind by 50% through the validation of the ""PivotBuoy"", an innovative subsystem that reduces the costs of mooring systems and floating platforms, allows faster and cheaper installation and a more reliable and sustainable operation. The PivotBuoy system combines the advantages of Single Point Mooring systems (SPM - pre-installation of the mooring and connection system using small vessels) with those of tension-leg systems (TLPs - weight reduction, reduced mooring length and enhanced stability), enabling a radical weight reduction of 50% to 90% in floating wind systems compared to current spar and semi-submersible systems but also enabling a critical simplification in the installation of traditional TLP systems. The PivotBuoy concept, initially conceived by its founder while at MIT, is currently at TRL3 after the proof of concept in a wave tank at 1:64 scale and it is the result of years of experience. The project proposes validating the concept at PLOCAN test site, integrating a part-scale prototype of the PivotBuoy single point mooring system in a 225kW downwind floating platform developed by X1 WIND. By testing in a relevant environment, the project will also validate critical innovations related to assembly, installation and O&M techniques, reaching TRL5 at the project end. The impact of the proposed innovations is sector wide: the system can be integrated not only in X1 WIND downwind platform but in any other floating platforms using single point moorings systems in the wind and in other sectors such as wave energy, tidal and oil&gas industries. The project consortium, combining experienced industrial partners from the oil&gas, naval and offshore wind sectors with cutting-edge R&D centres,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Determining how invasive S. Typhimurium infects human cells by transposon-insertion sequencing' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Salmonella enterica serovar Typhimurium infects a wide range of animal hosts and normally causes a self-limiting gastroenteritis in humans. However, new variants of this serovar known as ST313 have emerged as important pathogens in sub-Saharan Africa, causing an invasive disease in susceptible HIV+ or malarial individuals. Genome sequencing showed that the ST313 isolate D23580 is closely related to other nontyphoidal Salmonella. For example, D23580 shares 94% of coding genes with the well-characterised European SL1344 strain (ST19), and the two strains can be distinguished by 1000 single nucleotide polymorphisms, five D23580-specific phages, and a set of specific pseudogenes. Pseudogenes represent genome degradation, and 60% of the features present in D23580 are conserved in the host-restricted S. enterica serovars Typhi and Paratyphi A that cause enteric fever in humans. It has been suggested that ST313 represents a “human-adapted” version of S. Typhimurium which has developed the ability to transmit directly between humans.DISTINCT, which stands for “Determining how Invasive S. Typhimurium INfects human Cells by Transposon-insertion sequencing”, aims to investigate the ""human-specificity"" of S. Typhimurium D23580. I will use an improved global Transposon mutagenesis (TraDIS) approach to identify Salmonella genes required for survival in human monocyte-derived macrophages, but not in murine primary macrophages. This will be the first time that comprehensive genome-wide analysis is used to understand how bacteria distinguish between different mammalian host cells. Overall, DISTINCT will provide novel findings about the dangerous Salmonella pathogen and specifically about the invasive ST313 isolates that are causing a major public health problem in sub-Saharan Africa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The role of pax-5 in the pathogenesis of brain tumors'.

assistant: **Innovation**

Medulloblastoma is the most frequent central nervous system (CNS) tumor of childhood and it is higly malignant with a dismal long term prognosis. This tumour is thought to result from neoplastic transformation of undifferentiated precursor cells in the developing cerebellum. The paired box-containing genes (PAX) are transcription factors that have been implicated in the regulation of morphogenesis of the CNS, e.g. Pax-5 has a key role in patterning of the midbrain. PAX-5 is specifically deregulated in medulloblastoma and its expression positively correlates with cell proliferation. This and other evidence strongly suggest that PAX genes may participate as dominant oncogenes in the formation of brain tumours such as medulloblastoma. We intend to test this hypothesis by using transgenic mice as an in vivo model system to study the role of PAX-5 in brain tumour formation. Two different strategies will be used to direct the PAX-5 expression to the cells of the external granular layer of the cerebellum from where medulloblastoma is thought to originate, i.e. a classical transgenic approach and a knock-in" approach using embryonic stem cell technology. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cryptography from Unstructured Hardness' (KolmoCrypt) under Horizon Europe.

assistant: **Objectives**

Cryptography—and its basic tasks such as encryption, authentication and key exchange—is essential for ensuring privacy and security on the Internet. The question of whether “unbreakable” encryption methods exist has fascinated mathematicians and cryptographers for thousands of years, and is closely related to the famous NP vs. P problem. This question is still wide open and consequently, Internet security today relies on cryptographic constructions based on the *conjectured* hardness of some computational problems (such as e.g., the factoring problem, the discrete logarithms problem or various noisy linear algebra problems). However, these conjectured hard problems all contain significant (e.g., algebraic) *structure*, that may make them vulnerable to attacks. Furthermore, for tasks such as key exchange and public-key encryption, only a *handful* of candidate hard problems are known on which these tasks can be based. As a result, some unexpected algorithmic developments for structured problems could upend the whole infrastructure we rely on for communicating and transacting on the Internet.In this project, we propose to develop an alternative approach: a foundation for provably-secure Cryptography from *unstructured hardness* assumptions. Towards resolving this long-standing challenge, we will leverage our recently-discovered connection between Cryptography and the seemingly unrelated area of Kolmogorov Complexity. Specifically, we will develop new hardness assumptions rooted in Kolmogorov Complexity on which the cryptographic tasks (e.g., private-key encryption, key-exchange, public-key encryption) can be based. Critically, these assumptions will lack algebraic and other computational structure that may make them vulnerable to attacks. Overall, KolmoCrypt will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '5th International Neurotrauma Symposium' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The 5th Intemational Neurotrauma Symposium -a non-profit making project - is the continuation of a conference series initiated in 1991. Its purpose is to draw attention to the enormous medical and socioeconomic sequelae of brain and spinal cord injury at the international level. The Symposium in 2000 organized under the auspices and on behalf of the International Neurotrauma Society serves again as platform to bring together the top interdisciplinary representatives of the international neurotrauma community, reaching from the basic sciences to the clinical practice to present and discuss most recent results and concepts. Thereby, the understanding of injury mechanisms and treatment strategies will be markedly advanced as basis for the improvement of the clinical management and, thus, outcome of patients. Highlights of the Symposium are state-of-the-art keynote lectures on pertinent aspects, reaching from the molecular mechanisms of neuronal death or axonal regeneration to the clinical management and physical/neuropsychological rehabilitation. Top-ranking scientists and clinicians of a field will be available for the intensive interdisciplinary dialogue.Thereby, opportunities are provided for Young Researchers to obtain first hand information as stimulus for their own active involvement in laboratory and clinical research, as well as for making contacts with the leading experts for laboratory/clinical cooperation and training. A Special Young Investigator Session will be organised offering opportunities for Young Researchers to present and discuss their data. Excellent training will also be provided by introductory reviews during regular sessions and the poster presentations and discussions guided by experts. As an important spin-off the cumulation of novel data and con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Control of Centriole Structure And Number' (CENTRIOLSTRUCTNUMBER).

assistant: **Concept**

Centrioles are essential for the formation of several microtubule organizing structures including cilia, flagella and centrosomes. These structures are involved in a variety of functions, from cell motility to division. Centrosome defects are seen in many cancers, while abnormalities in cilia and flagella can lead to a variety of human diseases, such as polycystic kidney disease. The molecular mechanisms regulating centriole biogenesis have only recently started to be unravelled, opening new ways to answer a wide range of questions that have fascinated biologists for more than a century. In this grant we are asking two fundamental questions that are central to human disease: how is centriole structure and number established and regulated in the eukaryotic cell? To address these questions we propose to identify new molecular players, and to test the role of these and known players in the context of specific mechanistic hypothesis, using in vitro and in vivo models. We propose to develop novel assays for centriole structure and regulation in order to address mechanistic problems not accessible with today s assays. In our search for novel components we will use a multidisciplinary approach combining bioinformatics with high throughput screening. The use of in vitro systems will permit the quantitative dissection of molecular mechanisms, while the study of those mechanisms in Drosophila will allow us to understand them at the whole organism level. Furthermore, this analysis, together with studies in human tissue culture cells, will allow us to understand the consequences of misregulation of these fundamental centriole properties for human disease, such as ciliopathies and cancer. My group is already collaborating with medical doctors in the study of centriole aberrations in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A non-destructive pulse neutron multiple detector tool for use in environmental, hydrocarbon and mineral exploration work' (NUPULSE).

assistant: **Concept**

An innovative pulse neutron logging device with multiple detectors for simultaneous registration of fast, thermal and epithermal neutrons, as well as gamma radiation will be developed to prototype and tested in the market. Both the 14 KeV neutron source, and LiI, p-terphenyl single crystal detectors are new. The device marks a major breakthrough in miniaturised detectors, which can simultaneously register a range of elements (e.g. Fe, Cu, Zn, Au, As, Se, Ni, Cr etc.) as well as organic compounds such as hydrocarbons and pesticides. No comparable device is available anywhere in the world. The device has application in oil and gas exploration, mineral exploration and environmental studies (site assessment), as well as material science studies, defectoscopy, medical science, and detection of explosives and narcotics. The market is estimated at more than 100 M  annually.