RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pathogenic Triggers and Drivers of Venous Thromboembolism: Intermittent Hypoxia, Intravascular Cells and Extracellular Vesicles' (PROVE).

assistant: **Concept**

Venous thromboembolism (VTE) is a common, deadly condition affecting more than 1 million europeans, with 500.000 related deaths in EU per year. Many risk factors are established, but it is not known what triggers a VTE event, which hampers development of predictive and therapeutic measures. Hypoxia is known to play a major role in thrombus formation, but via which mechanisms is unclear. PROVE will be conducted at the university of Tromsø, using state-of-the-art equipment in a world-class thrombosis center of excellence (TREC) to uncover how hypoxia contributes to thrombus formation, with an emphasis on immunology and extracellular vesicles (EVs). TREC is composed of three units, combining epidemiology, clinic, and laboratory research, to conduct interdisciplinary, cutting-edge, research. PROVE will add aspects on immunology and EVs to TREC, two fields with greatly increasing importance in thrombotic research. PROVE will address three research objectives: (i) To unravel processes and pathways triggered by IH in intravascular cells (i.e. endothelial cells, monocytes and platelets); (ii) To define the characteristics and procoagulant activity of cell-specific EVs derived from intravascular cells activated by VTE-associated stimuli including IH, (iii) To comprehensively compare cell-specific EVs isolated from plasma of VTE patients and healthy subjects, towards future development of diagnostic tools and improved treatment regimens.This will be achieved by substantial characterizations and functional test of human cells and blood samples from both healthy individuals, and VTE patients. This will result in powerful data sets from protein expression analysis, and RNA sequencing, but also functional experiments to define effects of hypoxia on coagulation, and initiation of thro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A roll-free tilt sensor' (1994-1998).

assistant: **Innovation**

The conventional spirit level has been developed with the use of modern materials and sensor technology to offer a measure of tilt control for a large variety of civil, marine and military engineering scenarios. These include tilt sensbrs for remote controlled devices such as boring equipment Current tilt sensors have one major disadvantage in that they are designed to operate in a fixed vertical plane. Any rolling about their cross axes leads to measurement errors. The application of tilt sensors is therefore extremely limited to the monitoring of structures/devices which move principally along a single axis. Multi-axis monitoring of structure orientation is also undertaken by the use of gyroscopes, particularly within the aerospace sector. These are expensive and there is a continuing drive to develop low cost gyroscope systems or alternative, cheaper approaches. This project will seek to develop a roll-free tilt sensor by adapting the current principle based on the conventional spirit level. Careful design of the sensor geometry will allow accurate measurements of tilt independent from the cross roll attitude of the sensor. The progress of this fundamental research work will be influenced by the various selected test applications for the sensor, including mechanical moles, marine and aerospace systems. The following objectives are relevant to these sectors; Research and development of sensor design, materials and manufacture to allow high sensitivity at low cost, while reducing component size. Research and development of algorithms and signal processing to ailow coordination of multiple tilt sensors for a number of applications. Research and dev of the tilt sensor as an alternative to gravity erecting gyroscopes The realisation of a low-cost, roll-free tiit sensor wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Accounting for genocide: legal and scientific accounting practices in the wake of the Srebrenica genocide' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

“Accounting for genocide” empirically considers two sociomaterial practices of accounting for the 1995 Srebrenica genocide in Bosnia and Herzegovina. First, it scrutinizes efforts of national and international organizations to (ac)count how many Bosniak men were massacred and who was killed in July 1995. The second question about accounting analyses how those politically responsible at the time of the genocide are legally tried at the International Criminal Tribunal for the former Yugoslavia (ICTY). The first practice of accounting is based on inter alia forensic science, statistics, missing persons lists and witnesses conveniently subsumed under ‘atrocity victim identification’ (AVI), the second practice is the domain of adversarial legal proceedings, developing international criminal law, transitional justice and controversies over the Srebrenica genocide and legitimacy of the ICTY. A rigorous qualitative analysis focusing on the various locations—mass-graves, family assistance centres, forensic laboratories, the ICTY, public domain—where objects like remains, missing persons, identities, crimes, DNA evidence, and legal cases come to matter provides a deep understanding of the question of how both practices of accounting become entangled and co-construct each other.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biomarker Development for Postoperative Cognitive Impairment in the Elderly' (BioCog) targeting Seventh Framework.

assistant: **Abstract**

Postoperative delirium (POD) is characterized by the progressive deterioration of sensory/cognitive function after surgery with incidences of up to 30-80%. It is frequently followed by postoperative cognitive dysfunction (POCD) which tends to persist over time. In elderly patients, POCD resembles chronic dementia and appears to accelerate the cognitive decline in Alzheimer dementia. POD is strongly associated with subsequent dementia after 3.2 and 5.0 years of follow-up: odds ratio = 12.52 [95% CI, 1.86-84.21] corrected for baseline dementia, severity of illness, age. In an aging society like the EU, the socioeconomic implications of POD/POCD are therefore profound. At present no treatment exists and there are no established molecular or imaging biomarkers that allow risk and clinical outcome prediction. We will establish valid biomarkers panels for risk and clinical outcome prediction of POD/POCD in N=1200 surgical patients according to the regulatory requirements of the European Medicines Agency. Thus, a valuable database will be created not yet existing worldwide. Neuroimaging investigations, which directly provide information on brain structure/function, will include structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), arterial spin labelling (ASL), functional magnetic resonance imaging with simultaneous electrophysiology (fMRI/EEG) and glutamate MR-spectroscopy (MRS). These investigations will be complemented by genetic/gene expression analyses (sequencing of cholinergic candidate genes/corresponding transcripts) and analyses of plasma and cerebrospinal fluid markers (inflammatory/metabolic). Supported by bioinformatics approaches, integration of neuroimaging data with knowledge from molecular biomarkers (multivariate expert system) is expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stability of the atmosphere over Europe' under Sixth Framework.

assistant: **Concept**

Climate and its variability exert fundamental influence on the natural environment and human life. The IPCC TAR states that 'since the start of the satellite record in 1979, both satellite and weather balloon measurements show that the global averaged temperature of the lowest 8 km of the atmosphere has changed by 0.05±0.10°C per decade, but the global average surface temperature has increased significantly by 0.15±0.05°C per decade'.Higher lapse rate creates instability in the troposphere and makes atmospheric processes more dynamical. It may manifest in stronger convection and increasing storminess. There are many examples of such events from Europe, i.e. flooding in western Poland, the Czech Republic and Eastern Germany in July 1997 and torrential rains in Austrian villages in August 2002. The main objective of this project is to analyze the temporal and spatial variability of the static stability in the atmosphere over Europe and its relation to variability of precipitation totals, the frequency of extreme precipitation events, and the proportion of precipitation falling in extreme events.The project will evaluate the NCEP/NCAR re-analysis gridded daily data and available station soundings from Europe to analyze the temporal variability of temperature gradients near the ground and up to the middle troposphere. This variability will be related to variability of precipitation totals and seasonal course in different regions of Europe. The frequencies of extremely stable and unstable events will be examined as well as extremely deep lows and high-pressure gradient cases.The project will constitute an excellent opportunity for transfer of knowledge between our department and other European universities. We will send our researchers to the Institute for Coastal Research a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'METHODOLOGIES & TOOLS FOR SAFE ELECTROMAG. COMPATIBILITY DESIGN OF ELECT. COMPONENTS AND SYSTEMS FOR INFO., TELECOM., TRANSP. AND CONSUMER PRODUCT INDUSTRIES'.

assistant: **Concept**

Generalisation, customisation and validation of design methodologies and computer tools for the ElectroMagnetic compatibility (EMC) design of electronic components and systems. The simulation will allow EMC design early in the design cycle instead of the current test verification after product completion in the information, telecommunications, automotive and consumer products industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Interrogating Human Adult Hippocampal Neurogenesis'.

assistant: **Innovation**

The hippocampus is crucial for learning and memory and it hosts an extraordinary form of plasticity: the generation of new neurons throughout life, a process named adult hippocampal neurogenesis (AHN). Newly generated neurons grow in a specialised niche composed of unique vascular, glial, and neuronal elements. Impaired AHN leads to cognitive dysfunction and mood dysregulation in rodents. Recent work by my group reveals the persistence of AHN until the tenth decade of human life, as well as impairment of this process in patients with Alzheimers disease. The general aim of HumAN is to unveil the features that confer the human hippocampus with neurogenic potential, thoroughly characterising this niche in adulthood, physiological aging, and pathological conditions (AIM 1), and to identify potentially unique AHN signatures for specific neurodegenerative and psychiatric diseases (AIM 2). Moreover, we will determine, for the first time, whether new neurons integrate efficiently into the human hippocampus (AIM 3) and we will interrogate the subcellular machinery of these cells to unravel the mechanisms underlying AHN impairments in these diseases (AIM 4). The unprecedented quality of our collection of human hippocampal samples, obtained from 180 individuals (either controls or with specific neurodegenerative or psychiatric diseases), allows successful application of trail-blazing methodologies such as RNAscope, iterative indirect immunofluorescence imaging (4i)-microscopy, and super-resolution and stimulated emission depleted (STED) nano-resolution microscopy. HumAN will break new ground in the field of AHN by deepening our understanding not only of the mechanisms that control the maturation and synaptic integration of newly generated cells in human beings, but also of the pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent Manufacture from Powder by Advanced Laser Assimilation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

IMPALA will develop flexible and efficient Rapid Manufacturing processes of custom parts or small batches. SME end users will be at the forefront of this project, helping them increase their annual turnover by 20-50%, by producing a diversified range of high value components. Currently, manufacturing custom products such as artificial teeth can take several days or weeks and is very expensive. This project will reduce the time between conception and product delivery as well as reduce manufacturing costs. It will transform part of the resource intensive European Industry to that of knowledge intensive and will be a key enabling tool for European Innovation, vital for maintaining the EU as a world leader in Rapid Manufacturing. The consortium is composed of companies and research institutions with expertise in different domains such as automation, laser processes, materials, modelling and will seek to develop the following: • an automation system which will shorten the process time by implementing  an Imaging system, a CAD/CAM system and a CNC system • laser sintering and direct metal deposition processes for rapid manufacturing of producing 3D complex structures with enhanced properties, graded structures or composite structures from very small to large scale • a control process system to ensure good product quality and good reproducibility • a simulation tool based on modelling and experiments, to allow predetermining parameters for the production of high quality parts, right from the first time. It is environmentally friendly as there is no waste material and no need for solvent. It will also be used for repairing expensive parts, also reducing waste. Society will directly benefit from this process as it will support the generation of high value knowledge based jobs an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ironclad Quantum Security of Code And Lattice-based cryptography'.

assistant: **Concept**

Since Shor’s seminal algorithm, we know that quantum computers will break deployed public-key cryptography. Fortunately, there are quantum-safe solutions based on objects known as codes and lattices. These solutions were identified by an algorithm of Regev showing that if there is an attack, then a quantum compter will enable to solve problems believed to be intractable. Apart from this result, very few quantum algorithms were designed to assess or to break the security of code and lattice-based cryptography. IQ-SCALe is here to address this gap by opening a new and uncharted area for quantum algorithms.One of the motivations behind IQ-SCALe is a recent attack I designed against advanced cryptosystems. My attack based on Regev's approach demonstrates that it had not been sufficiently exploited. I also identified tools from Regev's approach to be at the core of a fundamental research area - sphere packing bounds - for which powerful generalizations are known. However, they involve more complicated objects (non-commutative groups) and the analogous quantum tools have not yet been designed.IQ-SCALe aims to design new quantum algorithms for this broader theory. Historically, Regev’s approach not only enabled us to assess the security of some cryptosystems by identifying an intractable problem, it was also leveraged to mount attacks as I have shown. The new quantum tools that I will design in IQ-SCALe will likewise lead to both the identification of useful cryptographic problems and the design of new algorithms for attacks and proofs of hardness. It will considerably increase our trust in code and lattice-based cryptography. Current quantum algorithms to assess the security of code and lattice schemes are adaptations to the quantum setting of classical approaches. This will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unveiling the origins of white-dwarf explosions' (CosmicLeap).

assistant: **Innovation**

The explosive deaths of white dwarfs are essential in heavy element nucleosynthesis, galaxy feedback, and for understanding the evolution of binary systems. Type Ia supernovae (SNe Ia) are famous for their key role as cosmological-distance indicators and in the discovery of the accelerating Universe. Recent high-cadence surveys, and theoretical advances, have hinted that SNe Ia may not be the dominant way in which white dwarfs explode, with the potential existence of large populations of faint and rapidly evolving white-dwarf explosions. These unexplored classes of exotic transients may come from white dwarfs being torn apart by intermediate-mass black holes, mergers with neutron stars, or collisions in triple systems, but the mapping between explosions and observed transients is undetermined. This project aims at providing the first complete census of the multiple ways that white dwarfs explode by mapping their observations to their explosion physics and constraining their diversity. This sample will be crucial for defining optimal samples of SNe Ia for cosmology, as well as determining the rates and contributions of white-dwarf explosions to the origin of the elements. We will achieve this by i) obtaining the largest ever, rapidly discovered and spectroscopically confirmed sample, of white-dwarf transients with detailed follow-up observations, ii) the application of machine-learning techniques (e.g., neural-network emulators) for rapid comparison to sophisticated explosion models, and iii) the determination of the rates and diversity of their explosions in different galaxy environments. The confirmation and exploration of the multiple explosion channels for producing normal SNe Ia and exotic white-dwarf transients will have major implications for their nucleosynthetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project '5th european international conference on biocatalysis and biotransformations'.

assistant: **Objectives**

The 5th Biotas Conference will be held in Darmstadt (Germany) from September 2-7, 2001, within a biannual Europe conference series on biocatalysts, biotransformation and biotechnology (usually attended by ca. 300 scientists). The scope of the conference is the gathering of European scientists from interdisciplinary areas whose main objective is the use of whole cell organisms or isolated enzymes as catalysts in the development of innovative strategies for the synthesis of fine chemicals and pharmaceuticals, for an accelerated development of environmentally friendly processes in industrial chemicals production that are characterized by mild reaction conditions to limit energy consumption and waste production. Most participants to FP5 have been active promoters to this conference, which will promote and strengthen further synergies for FP5 and related European biotechnology initiatives.