RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chromatin and Metabolism Chromatin-metabolism interactions as targets for healthy living' to be submitted under Horizon 2020.

assistant: **Abstract**

Metabolic disorders are at pandemic levels. Based on recent estimates, ~50% of Europeans are overweight, 20% are obese and 10% have type II diabetes. Obesity and insulin resistance impact European health to the tune of €110 billion per year. These disorders have genetic, nutritional and lifestyle causes. However, the molecular mechanisms that link nutrients and lifestyle to gene activity and chromatin are poorly understood, and drug targets are only starting to be identified. Pioneering experiments by ChroMe labs now reveal how sugars, exercise, the gut microbiome and novel drugs regulate chromatin. These novel links promise to substantially improve our understanding and treatment of metabolic disorders. National governments and the EU invest major resources to address the burden of the “metabolic syndrome”. However, there is an urgent need for expert human capital able to dissect metabolic diseases, exploit new targets and establish innovative therapies. No local nor international program currently provides adequate training at this emerging interface of chromatin and metabolism. ChroMe establishes a timely and intersectorial ETN that exploits Europe’s strengths in epigenetics, physiology and medicine to translate our molecular knowledge of chromatin–metabolism interactions into therapies. Our ESRs receive advanced training in emerging technologies, bioinformatic and translational approaches, and all engage in collaborative PhD projects co-supervised by academia and industry. ChroMe’s extensive transferable skills, dissemination and public engagement program equips our ESRs with the experience and personal network needed for a career in metabolic health. By systematically involving the non-academic sector at every level in our research, training and management, ChroMe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dynamics of Terrestrial Gravity Perturbations' to be submitted under Seventh Framework.

assistant: **Abstract**

A new generation of high-precision gravity sensors such as torsion pendulums and atom interferometers, and future concepts for kilometer-scale gravitational-wave (GW) detectors searching for ripples in spacetime from colliding and exploding stars, will make it possible to study gravity perturbations in the frequency range 0.1Hz to 10Hz. These include terrestrial gravity perturbations that are of interest to Earth scientists, but that are considered as noise contribution in GW detectors. The applicant wants to carry out a detailed study of terrestrial gravity perturbations in the above given frequency range. The analysis will include gravity perturbations from fault rupture, and from seismic waves that are predicted to live on interfaces deep inside Earth such as the core-mantel boundary. Numerical simulations will be used to generate full gravity time series based on dynamical models of the sources and of the propagation of the seismic disturbance. This research will provide a completely new approach to understand the first minute of earthquakes. Furthermore, results from the fault-rupture analysis will be used to determine the impact that gravity sensors could have in earthquake-early warning systems. The project will also investigate terrestrial gravity noise in GW detectors with focus on the poorly understood atmospheric perturbations. Infrasound fields, convection and turbulent air flow are all expected to generate significant gravity noise in GW detectors. The goal is to create improved models for atmospheric perturbations partially based on numerical simulations. The results will be used to develop strategies to mitigate this type of gravity noise in GW detectors. The outcome of this research will have great impact on future developments of ground-based GW detecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Untangling the Bacterial Chromosome: Condensin's Role in Sister Chromosome Separation and its Mechanisms' under Seventh Framework.

assistant: **Concept**

A prerequisite for chromosome segregation in all living organisms is the topological unlinking of sister DNA molecules, called DNA decatenation. Decatenation is performed by DNA topoisomerases that work by transiently breaking strand(s) in one DNA double helix and passing another double helix through the temporarily created gate. How DNA topoisomerases manage to recognize linkages between sister DNA molecules and how they promote decatenation of sister chromatids (but not catenation) is still largely unknown.The driving hypothesis of this project is that condensin promotes chromosome decatenation by guiding the unlinking activity of DNA topoisomerases. Condensin is a member of the family of SMC (Structural Maintenance of Chromosomes) protein complexes that is conserved from bacteria to humans. It forms large, ring-like structures that bind to and organize chromosomes. Efficient separation of sister chromosomes in the bacterium B. subtilis depends on the condensin complex. However, so far the precise role of condensin in chromosome segregation and its mechanisms are unclear.To test our hypothesis, we will establish a minichromosome in bacteria that segregates in a condensin-dependent manner and measure its decatenation in vivo in the presence and absence of condensin. We will investigate the mechanism by which condensin organizes DNA within the (mini-)chromosome using techniques like chromosome conformation capture (3C) and electron microscopy. Finally, we will attempt to reconstitute for the first time the entrapment of DNA double helices by ring-like SMC protein complexes using purified components. Our results will be pivotal for understanding the action of SMC proteins in general with important implications in the separation and segregation of chromosomes in bacteria,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Neural basis of natural navigation: Representation of goals, 3-D spaces and 1-km distances in the bat hippocampal formation – the role of experience' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The mammalian hippocampal formation contains place cells, grid cells, head-direction cells and border cells, which collectively represent the animal’s position (‘map’), distance traveled (‘odometer’) and direction (‘compass’), and are thought to underlie navigation.  These neurons are typically studied in rodents running on linear tracks or in small empty boxes, ~1×1 m in size.  However, real-world navigation differs dramatically from typical laboratory setups, in at least three ways – which we plan to study: (1) The world is not empty, but contains objects and goals. Almost nothing is known about how neural circuits represent goal location – which is essential for navigating towards the goal.  We will record single-neuron activity in bats flying towards spatial goals, in search for cells that encode vectorial information about the direction and distance to the goal. Preliminary results support the existence of such cells in the bat hippocampal formation. This new functional cell class of vectorial goal-encoding neurons may underlie goal-directed navigation.(2) The world is not flat, but three-dimensional (3-D). We will train bats to fly in a large flight-room and examine 3-D grid cells and 3-D border cells.(3) The world is not 1-m in size, and both rodents and bats navigate over kilometer-scale distances. Nothing is known about how the brain supports such real-life navigation. We will utilize a 1-km long test facility at the Weizmann Institute of Science, and record place cells and grid cells in bats navigating over biologically relevant spatial scales.  Further, we will compare neural codes for space in wild-born bats versus bats born in the lab – which have never experienced a 1-km distance – to illuminate the role of experience in mammalian spatial cognition.Taken t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Aegean Innovation Relay Centre' in the context of a Sixth Framework call.

assistant: **Objectives**

The primary objective of IRC-EGE will be to assist and advised the Aegean region industries to improve their abilities by upgrading their technologies trough the adopting of know-how originating from EU RTD activities. It will use the IRC Network, CORDIS, EUREKA and ESA to identify technologies with the potential for exploitiation in the Region and pro- actively assist them to mach indentified local needs with European offers by disseminiation of tehcnology profiles and by partner search. In addition, targe ted work will be done to determine innovative technologies emerging from regional industry and academia and assist them to formulate their offers on the web. IRC-EGE will take all the necessary measures to ensure that TOs and TRs produced will be of high standard and genuinely innovative. As a complementary activity, requests from regional companies which are outside the defined tasks of IRC-EGE will be signposted to appropriate network players, such as NCP network, other Turkish IRCs or local EU netwoek organisations. Correct communication channels such as preparation of information packages, links on the web site will be established with these organisations to inform componies about their services. In addition, appropriate follow-up mechnanism will be developed to monitor the outcome of signposting. All these activites will be carried out within the context of Europe as a whole, in collaboration with IRC network and related key players of EU Research and Innovation Platform. IRC-EGE will constantly end eavur to improve its standards of performance by learning from the experiences of established IRCs. During the duration of the project, core staff will participate in training activities offered by other IRCs and the Central Unit. IRC-EGE will accomplish these object
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Disputing Medicine: Medical Dissertations at the Academy of Turku (1640–1828)'.

assistant: **Innovation**

The early modern period witnessed the gradual emergence of the unified field known today as science. The primary linguistic medium of all educated communication was Latin. Accordingly, Latin played a crucial role in how new scientific ideas were advanced and transmitted in (early) modern Europe. One of the most central – yet most neglected – literary forms employed to this end was the dissertation. Over the course of the 17th and 18th centuries, what was originally a collection of orally defended theses evolved into a self-sufficient piece of research. However, this transformation still lacks a systematic diachronic analysis and seems to be understood only broadly. Focusing on a corpus of medical dissertations published at the Royal Academy of Turku (Finland) between 1640 and 1828, MedDis action aims to provide a more comprehensive understanding of this crucial process in the history of Western science. To this end, the ER will first transcribe the corpus into an easily searchable database with the aid of Trankribus software; second, he will examine the history of medical education at the Academy of Turku; and, third, he will investigate the evolution of the genre at the Academy of Turku in its wider European context. Combining digital tools with more traditional philological methods, the action will yield completely new information on how the dissertation transformed from its early modern to its modern form and function. The ER has expertise in Neo-Latin, intellectual history and digital humanities. The action will take place at the Department of Classical Philology and Neo-Latin Studies at the University of Innsbruck. Home to the ERC project 'Nova Scientia: Early Modern Scientific Literature and Latin' (NOSCEMUS) and the Ludwig Boltzmann Institute for Neo-Latin studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Capacity building for the control of Avian influenza through technology transfer and training' under Sixth Framework.

assistant: **Concept**

Avian Influenza (AI) or Bird Flu" is a highly contagious viral infection which can affect all species of birds and can manifest itself in different ways depending mainly on the pathogenicity of the virus involved and on the species affected.  The highly Pathogenic Avian Influenza (HPAI) causes serious disease with high mortality (up to 100%)  noticeable to the OIE. More interesting HPAI is shown to infect and cause death in humans. A total of 103 deaths have been recorded by the WHO due HPAI H5N1 infection in a number of countries like Vietnam, Turkey, Azerbaijan and Iraq. Besides the fact that a number of countries were surprised by the outbreaks of HPAI, a greater number of developing countries are missing the adequate tools to detect and differentiate t he HPAI and are lacking experience to manage the outbreak of the disease. Thus there is an urgent need for technology transfer and training.  To fill these gaps, the partners of this consortium will:  i) organize technical workshops to facilitate the technology transfer particularly in the field of molecular diagnostic tools for pathogen detection and differentiation, to reinforce epidemiological analysis for monitoring and modelling of Avian inlfuenza especially and to respond to outbreaks with infectious dis eases of livestock in general.  ii) provide training through organization of seminars and short term courses in well qualified laboratories of a number of members states of European Union.  iii) organize technical workshops, courses and training in the INCO target countries to improve the technical experimental level of the staff and laboratories in charge of livestock infectious diseases"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Using the precision mouse genetic tool MADM to elucidate the role of EGFR in directing beta cell differentiation and pancreatic morphogenesis'.

assistant: **Concept**

Insulin producing beta cells are derived from bipotent pancreatic progenitors (bi-PPs) that constitute the primitive ductal epithelium. While we now know a great deal about the transcriptional networks required for endocrinogenesis and commitment to the beta lineage, considerably less is understood about the cellular events that initiate delamination and activate differentiation networks. The host group recently found that ligand-specific Egfr signaling is essential for these processes. Signaling by the highly potent Egfr ligand betacellulin diminishes apicobasal polarity leading to upregulation of Ngn3, delamination, and beta cell differentiation. The overall aim of this proposal is to elucidate the role of Egfr signaling in the beta cell differentiation process. I will ask: Is the seemingly stochastic differentiation of bi-PPs regulated by inherent differential Egfr signaling? Do quantitative differences in this single pathway lead to different cellular outcomes? How does the targeted loss of Egfr in Ngn3-expressing endocrine precursors affect their differentiation? What are the genes regulated by Egfr pathway activation that putatively commit Ngn3+ progenitors to a beta cell fate? And how does the disruption of endocrine differentiation affect ductal morphogenesis? Answers to these questions have remained elusive because of the difficulty of observing individual cell behaviors in situ in the developing pancreas. To meet this challenge, I will adapt the cutting edge mouse genetic tool Mosaic Analysis with Double Markers (MADM) to quantitatively manipulate Egfr levels in bi-PPs and to concomitantly label altered cells. The successful implementation of MADMouse will deliver findings of immediate interest to investigators seeking to improve the directed differentiation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Macro-Financial Modelling for Robust Policy Design' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

During the global financial crisis and ensuing Great Recession, economists at policy-making institutions had little choice but to augment macroeconomic models with ad-hoc assumptions and adjustments in order to provide analysis and advice for policy makers. Our consortium’s proposal aims to move policy-focused macroeconomic modelling beyond this approach to the endogenous modelling of the dynamics resulting from financial risks and related decision making in banks, households, firms and public institutions. We bring together four broad lines of research to systematically develop new behavioural and institutional building blocks, integrating them in policy-focused macroeconomic models and using these models in a new framework for policy evaluation. In terms of building blocks, one line of research moves beyond the assumption of representative and homo-oeconomicus-type agents to incorporate micro-behavioural realism in decision making, while a second line of research advances the modelling of financial institutions, their fragility and the dynamics of systemic risk. The third line of research integrates these new building blocks (including a selection of those developed by researchers outside the consortium) in a new generation of policy-focused macroeconomic models. In parallel, in the fourth line of research new policy evaluation tools are developed, with a focus on robust tools aimed at containing financial contagion and boom-bust cycles, maintaining fiscal sustainability and coordinating monetary, fiscal and regulatory policies in normal and crisis regimes. The consortium comprises researchers with a strong track record in advancing the frontier on behavioural and institutional modelling, highly influential macroeconomic modellers as well as seasoned veterans of model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable housing in europe' (SHE), addressing dissemination and exploitation.

assistant: **Impact**

The need is a widespread diffusion and application of sustainable housing. The challenge is to move from the extraordinary to the ordinary procedure, balancing the investment cost with the economic, environmental and social benefit. The SHE project, proposed by social housing organisations, aims to manage the building process of some 900 sustainable dwellings, according to Agenda 21, to develop a set of best practice solutions. A set of work packages and some innovative work tasks (participation and social/economic aspects) are defined. A team of experts will give scientific support in specific topics. A permanent wide dissemination will be developed towards targeted groups. Expected results are practical methodologies to improve assessment of best practice solutions, direct participation and involvement of the citizen and integrated approach.