RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multi-modal interrogation of instinctive behaviours and intrahypothalamic connectivity' (DRIVOME).

assistant: **Concept**

Mammalian behaviour is driven by instincts such as hunger, sex and aggression which are familiar to everyone from daily experience. Anomalies in these instincts cause disorders such as anorexia, excessive sexual drive and episodic dyscontrol syndrome, and potentially also psychologically difficult situations like marital infidelity. Neuronal circuits that drive these instincts reside in the hypothalamus where research is gaining pace rapidly.Recent work has uncovered hypothalamic neuronal populations in mouse, that can drive the following fundamental mammalian behaviours: feeding (Aponte et al., 2011, Betley et al., 2015), sex/aggression (Lee et al., 2014, Lin et al., 2011), sleep/wakefulness (Adamantidis et al., 2007, Jego et al., 2013) and parental behaviours (Marlin et al., 2015, Wu et al., 2014). Older work has demonstrated similar effects with cruder manipulations of the hypothalamus in several species. Classical work in ethology (Lorenz, 1981, Tinbergen, 1951) as well as newer anatomical insights (Swanson, 2000) have outlined hypotheses for how neuronal network architecture may guide the organization of instinctive behaviours into the coherent, adaptive, context-relevant displays evident throughout the animal kingdom. Modern techniques (opsins, genetically encoded calcium indicators, transgenic mice, multi photon imaging of deep brain structures and optrode recording) are now ripe for comprehensive cell-type specific probing of the hypothalamic networks in charge of fundamental drives and possibly emotions. We propose to use these methods to elucidate the intrahypothalamic wiring diagram (the connectome of drives, or 'DRIVOME') that can explain how instincts are orchestrated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Assumption-Lean (Causal) Modelling and Estimation: A Paradigm Shift from Traditional Statistical Modelling', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

I propose a cutting-edge and transformative paradigm for statistical modelling that is crucial to enhance the quality of data analyses. Leveraging my expertise in causal inference and semiparametric statistics, I will establish the fundamental principles of a comprehensive estimation theory, which maps model parameters onto generic, interpretable, model-free estimands (e.g., association or effect measures) with favourable efficiency bound, and harnesses the power of debiased (statistical/machine) learning techniques to estimate these. My core objective is to develop a flexible and accessible data modelling framework, called ‘assumption-lean modelling’. This framework will deliver minimal bias and maximal interpretability, even in the presence of model misspecification, along with honest confidence bounds that account for model uncertainty.Debiased learning is at the core of this research. While gaining popularity, a rigorous scientific optimality theory is lacking. I shall draw on my expertise in (bias-reduced) double robust estimation to develop optimal debiased learning estimators. These utilize learners that optimize strategically chosen loss functions to achieve low variance and high stability, along with confidence intervals that are valid under weak conditions on the learners.I will connect to timely, exciting developments in statistics, such as debiased learning of function-valued parameters and the construction of confidence bounds for such parameters. I will offer novel avenues into these problems by incorporating the assumption-lean modelling principles and connecting to real-world needs.I will develop assumption-lean modelling strategies to tackle significant challenges in causal modelling, including target trial emulation, causal mediation analysis, and stat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European initiative to improve knowledge, treatment and survival of haemophagocytic syndromes in children' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Haemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening inherited immune disorder of early childhood characterised by an uncontrolled immune response. Three disease causing genes have been identified in about half of the patients. Diagnosis is difficult, pathophysiology poorly understood, and treatment unsatisfactory with about 40% of the children dying from treatment failure or toxicity. All European scientists active in research and treatment of HLH have joined in a consortium to enforce collaboration, combine the various expertises, and provide access to material and data. In vitro studies and several murine models for HLH and diseases predisposing to HLH, will be used to get more insight into the pathophysiology of the diverse genetic defects. Studies will address the role of triggers and antigen-presenting cells, the influence of cytokines in the initiation and propagation of the uncontrolled immune response, the interaction of immune effector cells and soluble factors, and the mechanism of cytotoxicity in lymphocytes and natural killer cells. Data about geno-phenotype will be combined to evaluate how known and unknown genetic defects reflect on the clinical course and immunophenotype of the patients. A diagnostic algorithm, incorporating knowledge from the known defects, will be developed and optimised in all countries to facilitate earlier and reliable diagnosis, and to separate patients with unknown defects or acquired HLH. The identification of risk factors for treatment failure and toxicity will be used to design improved treatment strategies. An experimental treatment will be tested in a murine model and will be the basis for a less toxic treatment in the future. Earlier diagnosis, better insight into the pathophysiology, and development of l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'New Eco-efficient Industrial Process Using Microrstructured Unit Components - Safe and Environmental Friendly Production of Sensitive Compounds Ensured by Process Intensification'.

assistant: **Objectives**

The overall goal of the NEPUMUC project is to make the benefits of microreaction technology available for industrial purposes, in particular nitration chemistry. Therefore, the project partners will jointly develop, test and evaluate a new microreaction p rocess as a prototype to demonstrate that even under industrial requirements microreaction technology can be made available in a flexible and multi-purpose manner. The project will address these different technical challenges by new and highly innovative methods and technologies. For the first time, simulation and modelling tools will be consequently applied for the design of both the entire nitration process and its core component, the microfluidic reaction unit. This will be a totally new approach to ove rcome the problems of achieving sufficient throughput although microfluidic structures are used. To enable a robust, stable and safe proccessing under high industrial requirements, new microfluidic sensors will be developed and adapted to the microreaction units. These sensors will allow an accurate process monitoring and process control in the immediate vicinity of the most important part of the process: the microreactor. For the first time, microfluidic sensors will become an integral part of an industria l microreaction process. Finally, the development of an appropiate automation system that interacts accurately with both microfluidic sensors and macroscopic actuators (pumps, heating/cooling devices ) will make microreaction technology processable like c onventional chemical processes. An evaluation procedure will be an integral part of the entire project. The evaluation will clearly describe the technical and economic benefits and potential limitations of the microreaction process. Besides process intensi ficati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhancing innovation management capacity of SMEs in Republic of Srpska' in the context of a Horizon 2020 call.

assistant: **Objectives**

Republic of Srpska is one of two constitutive entities within the Bosnia and Herzegovina, and is autonomous in area ofeconomic development. In order to provide stronger support to development of business sector (in particular the SMEs, thataccount for 99,8% of all businesses in RS), RS has decided to apply for the membership in the EUNORS (EEN RS) willprovide SMEs with opportunities to explore their development and innovation potential in cooperation with partners fromother EEN countries. EUNORS will strengthen regional cooperation (SEE and EU), and strengthen cluster development.EUNORS will cooperate with RS stakeholders and other institutions providing SME support services.The project aims are supporting SMEs on knowledge bases to bring their ideas to the market and scale up business bydeveloping a innovation structure and implementing to it action plan. The n innovative SMEs will foster interaction among theSMEs actors and ultimately support European countries to gain state of the art technical knowledge and achieve the abilityneeded to drive innovation to the marketEnhanced growth and profitability of 48 SMEs in RS through provision of specialized innovation support services withinEUNORS network.Specific objectives:• Enhanced innovation management capacity of 48 companies within 24 months in Republic of Srpska.• Provide key account management support for 8 successful applicants of SME Instrument• Build capacity of 8 experts form Consortium member organizations to handle innovation management capacityassessment and innovation support services provisionThe implementation of this innovation action will give an SMEs performance model in the knowledge based society and willhave a great impact in developing the Republic of Srpska SMEs culture where there is a need to fost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Industrial research into the properties of molecular capsules in commercially relevant media'.

assistant: **Concept**

Encapsulation technologies protect valuable cargos in chemical mixtures by coating the cargos in a protective material until they are needed. Such technologies are used in commercial applications ranging from the protection of enzymes in laundry detergent, to the targeted release of drug molecules in a specific part of the body. Because encapsulation technologies are applicable to a broad range of industries, and they substantially improve the properties of existing products, the chemical encapsulation market is expected to be worth €17Bn by 2020.Aqdot is a growing chemical and materials company, which has developed an award-winning platform technology for providing encapsulation solutions in diverse fields, such as home care, health and beauty, food, and agriculture. It is seeking to recruit a Research Chemist to investigate the behaviour of its nanotechnologies in formulations that are suitable for various industrial applications.To succeed in commercialising these new capsules, it is vital to understand how they function in different media, such as gels, lotions and detergents. The Innovation Associate requested for this project will use their expert knowledge of the chemistry that underpins cargo encapsulation to investigate the strength of binding interactions in different media: improving Aqdot’s knowledge base and in turn accelerating commercialisation of the new capsules. The successful candidate will have a PhD, will have an aptitude for translating fundamentals of physical/supramolecular chemistry into practical product properties, and will bring a ‘can do’ attitude so that they can thrive during this opportunity with an ambitious SME.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elimination of geometric parts rejection in precision cored investment castings' (1994-1998).

assistant: **Innovation**

The Industrial Objective is to improve the process of precision investment casting for application to aeroengine components by addressing perceived low yield in the production of ceramic cored wax patterns. Such a process would enable the SME dominated supply chain to maintain the industry's competitive position in response to the threat from emergent industries on the Pacific Rim. The primary Technical Objective is to develop an integrated system for die tool design and wax injection machine control, to control the flow and solidification of wax to minimise residual stresses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic Life from the bottom up' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Life is a mystery, with questions about how it emerged and if it exists elsewhere. Synthetic life can bring us closer to answers to these millennia-old questions. It is also extremely powerful to evolve new materials and catalysts, similar to directed evolution with bacteria. It begs the question, can we synthesize life?SynLife aims to synthesize life from man-made molecules following NASAs definition:Life is a self-sustaining system capable of Darwinian evolution.Chemically fueled droplets will be the self-sustaining compartments. These self-dividing droplets compete for fuel (i.e., food) to thrive and will decay without fuel. We will develop self-replicating molecules that can mutate and partition inside of these droplets, so the droplets obtain an identity. For example, a population of droplets with replicator A differs from a population with replicator B. Moreover, these replicators affect the droplets phenotype, for example, by helping division or by offering longevity. To date, the combination of self-sustaining droplets and replicators has never been achieved.Finally, populations of droplets compete with each other. In fueling-starvation experiments, it is expected that, from time to time, a droplet mutates into a better-suited one and passes this information on to the next generation. If we reach this ambitious goal, we have produced a synthetic system capable of Darwinian evolution.The results will mark a massive step forwards in our understanding of life. It also sheds new light on the molecular mechanisms that may have played a role in the origin of life. It will have implications for the biophysics community, too, as our findings help understand how additives to droplets affect their properties, just like in membraneless organelles. But, most excitingly, Syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Services to enhance the innovation amangement capacity of SMEs in Roamania macro-region 1' under Horizon 2020.

assistant: **Concept**

InnoCap Transylvania - Services in support of innovation for Romanian SMEsThe objectives of this proposal are the following: - increase the efficiency and efectiveness of innovation process of local beneficiaries of SME Instrument program and innovative SMEs with significant innovation activities and high potential for internationalization;- facilitate SMEs access to consultancy services for innovation management to address bottleneck to creating an economic impact; - support innovative SMEs to raise the company's profitability and competitiveness on international market.


**Keywords:** Increase the efficiency and effectiveness of innovation process of local beneficiaries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlling the Motion of Complex Molecules and Particles' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main objective of COMOTION is to enable novel experiments for the investigation of the intrinsic properties of large molecules, including biological samples like proteins, viruses, and small cells-X-ray free-electron lasers have enabled the observation of near-atomic-resolution structures in diffraction- before-destruction experiments, for instance, of isolated mimiviruses and of proteins from microscopic crystals. The goal to record molecular movies with spatial and temporal atomic-resolution (femtoseconds and picometers) of individual molecules is near.-The investigation of ultrafast, sub-femtosecond electron dynamics in small molecules is providing first results. Its extension to large molecules promises the unraveling of charge migration and energy transport in complex (bio)molecules.-Matter-wave experiments of large molecules, with currently up to some hundred atoms, are testing the limits of quantum mechanics, particle-wave duality, and coherence. These metrology experiments also allow the precise measurement of molecular properties.The principal obstacle for these and similar experiments in molecular sciences is the controlled production of samples of identical molecules in the gas phase. We will develop novel concepts and technologies for the manipulation of complex molecules, ranging from amino acids to proteins, viruses, nano-objects, and small cells: We will implement new methods to inject complex molecules into vacuum, to rapidly cool them, and to manipulate the motion of these cold gas-phase samples using combinations of external electric and electromagnetic fields. These external-field handles enable the spatial separation of molecules according to size, shape, and isomer.The generated controlled samples are ideally suited for the envisioned precision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nomad Movements and Digital Impacts in Cities' in the context of a Horizon Europe call.

assistant: **Objectives**

Over the past decade, the expansion of the so-called platform economy has accelerated the digital transformation of our daily lives. At the same time, a cohort of new workers linked to these platform economies, characterized by high levels of geographical mobility, are central actors in the transformation of consumption patterns, urban lifestyles, leisure activities, and work culture in numerous cities across the globe. NOMADIC is a training and policy-oriented project involving an international, cross-sectoral, and interdisciplinary network that aims to promote an adaptive, inclusive, sustainable, and equitable urban future, thereby reducing inequality and segregation in the selected cities (and beyond).Objectives:- To understand the dynamics and impact of digital nomadism in urban environments.- To build a network of stakeholders and experts.- To develop policy guidelines and best practices to design strategies that promote sustainable and inclusive urban environments.- Provide excellent training and supervision.NOMADIC raises:a) explore and characterize the lifestyle, consumption, and everyday life of high-tech and gig workers and their connection to socio-cultural urban change;b) analyze how these new social practices are related to the platformisation of urban life;c) formulate digital-related engagement and empowerment actions for community liveability and social inclusion, seeking an adaptive, inclusive, sustainable, and equitable urban future that aims to reduce inequality and segregation.NOMADIC is an international, intersectoral, and interdisciplinary network from across Europe and the Americas that will join forces to develop a cross-cutting study that explores and understands the multiple impacts of digitalization, platformisation, and the emergence of techn