RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European network for understanding the mechanisms of severe asthma' (ENFUMOSA) targeting Fourth Framework.

assistant: **Abstract**

- To provide a network between major centres across Europe to generate and exchange knowledge and information about severe asthma. - To enable comparisons to be made between the type, pattern, magnitude and underlying causes of severe asthma in each Member State by contributing patients to a single protocol. - To analyse clinical and laboratory material as surrogate markers of airway inflammation and apply direct assessment of airway inflammation by bronchial biopsy and lavage. - To investigate the natural history of severe asthma with a view to long term follow up.We propose to establish a European Network to draw together expertise from some of the leading asthma research groups. To achieve our objectives we wish to work to a common protocol in which severe asthma defined by recurrent hospital admissions will be compared to a control group" with less severe disease. Partners will contribute 20 patients into each group identified on the basis of hospital records. In accordance with the facilities available, each partner will contribute clinical, physiological and biological fluids and tissue/cell samples to a laboratory with specific expertise. In the first phase a detailed questionnaire including life quality assessment and measurement of pulmonary function and bronchial responsiveness will be undertaken. Biomarkers of airway inflammation will be measured including bronchial mucosal biopsy, analysis of blood, induced sputum and urine for inflammatory cell markers, PCR-based virus identification, assessment of allergic status and exposure to indoor and outdoor air pollutants. The second phase will consist of a longitudinal follow-up with assessment during exacerbations and at regular six monthly intervals at which time clinical, physiological and non-invasive biomarker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Optimal Strategy to Innovate and Reduce energy consumption In urban rail Systems'.

assistant: **Innovation**

For many transport modes, energy reduction strategies can be effectively formulated at the level of the vehicle or vessel. New technologies can therefore be introduced to a vehicle and the direct energy savings can be readily quantified. However, such approach is not suitable to be employed for urban rail, where it is not sufficient to consider only the energy performance of vehicles; the energy associated with the infrastructure, as well as the influence of the mode of operation are to be considered too. In other words, urban rail systems are complex environments and their energy consumption is characterised by a wide range of inter-dependent factors. This means that it is often extremely difficult to assess the net benefits of introducing new energy saving technologies. For example, whilst a new technology might yield improvements in certain respects, it might also compromise other aspects of system performance. What is needed, and what has been lacking so far, is a holistic approach for the reduction of energy consumption for urban rail systems embracing vehicles, infrastructure and operation, as is proposed by OSIRIS. The project will start from the definition of Key Performance Indicators and Standard Duty Cycles to measure energy consumption in urban rail systems. Then, rather than focussing only on specific technologies, it will address the issue from the system-level ensuring that progresses on energy reduction are substantial. The effectiveness of solutions and their full potential will be proven by means of simulations and pilot tests. OSIRIS will introduce  the entire discovered knowledge into a Decision Support Tool, for strategic decision making of companies (i.e., operators) and governments (i.e., public authorities). OSIRIS is fully aligned with the polit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The homotopy and geometry of gauge groups' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content  The two parts of the programme utilise techniques from homotopy theory and differential geometry in the study of gauge groups; motivation comes initially from physics. Firstly, influenced by the extent to which the geometry of t'Hoof's model of quark confinement is determined by the centre of the structure group of a bundle, I am developing a model for this gauge theory involving new ideas in classifying space theory within homotopy theory: this work began in my PhD thesis. Secondly, with M.Marcolli, I defined the gauge theory describing free fermions on a two dimensional surface and computed the contribution to the frame anomaly due to the presence of singularities. This is just the first step in a programme analysing the contribution that singularities give to the different anomolies in any gauge theory using geometric methods. I have visited Aberdeen and talked about my work and plans with several members of staff. I am convinced that it is a good place to pursue my research. The team is increasingly interested in the topology and geometry mathematics related to physics and with my early training as a physicist the mathematical emphasis will be particularly beneficial for my future development as a researchworker. There are no obvious industrial connections.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Using a novel protein degradation approach to uncover IRF4-regulated genes in plasma cells'.

assistant: **Concept**

Plasma cells (PCs) are antibody-producing cells that develop from activated B cells in an immune response. Antibodies produced by these cells are essential for the clearance of pathogens and long-term protection against recurrent infections. PCs can also be pathogenic in autoimmune disease, where self-recognising antibodies are produced, and cancer, in the form of multiple myeloma. An understanding of the molecular pathways that control PC function is therefore necessary for understanding human immunity and these pathologies. Interferon Regulatory Factor 4 (IRF4, gene name Irf4) is a transcription factor whose deletion in mouse models results in the loss of all PCs. Because of this, the genes that are regulated by IRF4, and hence which cellular pathways are required for PC survival, are unknown. Here, I propose to use a revolutionary approach to determine the target genes of IRF4. I will use targeted protein degradation to deplete IRF4 in mouse PCs, and then determine the immediate changes in transcription following IRF4 loss using a state-of-the-art RNA sequencing technique, known as SLAM-seq. The advantage of this approach is that I can analyze changes in transcription before the onset of the survival defect. I will then study the functional roles of the identified IRF4 target genes in PCs. This is a multidisciplinary project that combines molecular biology approaches with cell biology and immune physiology. In addition, this proposal allows for transfer of knowledge from myself, an expert in the regulation of cell survival, and the host institution, which will train me in molecular biology techniques and expertise in PC biology. IRF4 has been implicated in both autoimmune disease and multiple myeloma, and so this proposal addresses a basic research question that has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Learning from the locals: A metagenomic investigation into the plant biomassdegrading capacity in Norwegian native herbivores' (PBDNH), addressing dissemination and exploitation.

assistant: **Impact**

Understanding the enzymology of plant biomass conversion is a key issue in the world’s desire to establish a sustainable bio-based economy. Currently available enzyme technology is insufficiently effective, and several fundamental key questions as to how enzymes and plant cell walls interact remain. The present project will address these issues by studying a natural biomass-converting ecosystem adapted to the local biomass, namely the microbial community (microbiome) resident in the digestive tract of Svalbard reindeer.  The project aims to generate a metagenomic reconstruction of microbial community structure and its metabolism using a combination of deep 454 sequencing technology as well as functional and sequence-based screens. It will specifically target recovering genetic determinants encoding genes underpinning the deconstruction of plant structural polysaccharides. Relevant genes identified from the metagenome using bioinformatic and functional screens, will be cloned, over-expressed, and their gene products characterised in detail. In addition to creating fundamental insight into the microbial ecology and enzymology of plant biomass conversion, insight into the reindeer microbiome may also contribute to a better understanding of the health and well-being of this important Norwegian animal. This project will link the most prominent Norwegian research group on biomass enzymology (Prof. Vincent Eijsink, UMB) to one of the most prominent research groups in gut metagenomics (Prof. Morrison, CSIRO, Australia) and to a truly international network of (highly relevant) contacts and collaborations. The project complements existing activities in the host laboratory on polysaccharide converting enzymes and complements ongoing international efforts in herbivore microbiome me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design and modelling improvement of magnetic components in power electronics for aerospace applications' (DEMOMAG).

assistant: **Concept**

- Accurate behavioural models, accounting for geometry and frequency dependent effects are obtained for the SMPS magnetic components. Layers position, sensitivity to track and isolation dimensions, etc., will be calculated with the new MEMT tool.- Improvement of magnetic component performance, because the capability to obtain an accurate model before building the magnetic component and the physical insight by means of the Finite Element Analysis allows component optimisation.- Improvement of SMPS, because performance of SMPS is highly dependent on magnetic components. Efficiency, stress, size, thermal management, etc, are more accurately calculated since accurate models are available.- Improvement of design process: allows performance of electrical simulations and to check whether results are as expected before building magnetic component and SMPS.- Development time reduction: design will not be iterative. Iterations will be done by computer, but not in the construction of the magnetic components.- Cost reduction: due to the development time reduction and manufacturing cost of low profile PCB transformers, that is lower than hand made transformers when leakage inductance reduction is a must, as in this case.Performance and design process of Switched Mode Power Supplies (SMPS) are improved by means of the improvement of the design, modelling and manufacturing process of the power magnetic components. The influence of magnetic components in high frequency DC/DC converters is critical. Furthermore, the performance of HF magnetic components is very dependent on winging strategy and geometry effects, which are not properly calculated and predicted today. The Magnetic Element Modelling Tool (MEMT), based on Finite Element Analysis calculations, is used to generate accurate fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plasmonic Metamaterials' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

IIn this program I will demonstrate control of light at length scales well below the free-space wavelength, leading to entirely new fundamental phenomena and important applications. The research program is built on specially engineered metamaterials composed of metal nanostructures that support surface plasmons that are embedded in a dielectric. The program is composed of three strongly related topics:1) I will experimentally demonstrate an entirely new class of optical metamaterials that posses a refractive index that can be tuned over a very large range: -10 < n < +10. Based on coupled plasmonic waveguides, these materials will, for the first time, show true left-handed behaviour of light (n < 0) in the UV/blue spectral range. I will demonstrate negative refraction of light and use these materials to demonstrate the “perfect lens” which enables sub-wavelength imaging of (biological) nanostructures.2) I will use plasmonic metamaterials to engineer the flow of light in thin-film solar cells. By controlling the scattering and trapping of light using plasmonic nanostructures integrated with semiconductor waveguide slabs I will demonstrate ultra-thin solar cells with efficient collection and conversion of infrared light, aiming at beating the ergodic light trapping limit.3) I will demonstrate strong coupling between light and mechanical motion in the smallest possible volume. Light trapped in plasmonic metamaterials exerts a force that can lead to a shift in the plasmonic resonance frequency which in turn provides feedback on the mechanical motion. We will use this nanoscale coupling mechanism to actively cool and heat mechanical motion in plasmonic nanostructures and use this phenomenon in a new type of plasmon-based quartz oscillator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Identification of common features of cis-regulatory regions underlying co-regulation of genes in developing mouse hippocampus' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We plan to employ a combination of computational and experimental approaches to identify features of the cis-regulatory regions that underlie common patterns of gene expression observed during hippocampal development. Rather than grouping genes on the b asis of the overall similarity of expression profiles, we plan to first decompose the profiles into simpler modes, using the singular value decomposition (SVD), and then to look for the features associated with individual modes. We performed SVD of the p ublished expression data set from gene profiling of the hippocampal development in mouse (Mody et al., 2001, PNAS 98: 8862-7), which revealed that most of the differences in expression patterns can be represented by the first two modes, reflecting variat ion in the amplitude of expression, and the difference between up and down regulation in the course of development, respectively. In further work, we plan to identify features specifically associated with each of these two modes. The computational work will constitute of identification of putative regulatory regions, annotation of these regions with known transcription factor binding sites (motives), and then with putative higher order features built from these motives. Such features will be scored fo r their statistical association with loadings of a particular mode. For a small number of the top scoring features we will also perform in silico hypotheses tests (on another part of the data set). The role of the most promising features, in the regulati on of the genes that contain them (putative target genes), will be verified in the experimental part of the project, performed in the hippocampal neuronal culture. Previous work of the applicant demonstrated that this culture system is a good model for g ene regulation in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Crosstalk Between Nitric and Carbon Monoxide in Suppressing the Pathogenesis of Cerebral Malaria' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Malaria, can lead to the development of cerebral malaria (CM), a lethal syndrome that claims more then one million deaths per year. There is currently no effective treatment against CM. We have shown that the gas carbon monoxide (CO), generated via heme catabolism by heme oxygenase-1, inhibits the onset of CM in mice (1). While not affecting parasitemia per se, CO inhibits all the major pathologic hallmarks of CM, including blood brain barrier disruption, brain micro-vascular congestion and neuroinflammation. The mechanism underlying this protective effect relies on the ability of CO to bind the heme groups of cell free hemoglobin, released from infected red blood cells. Once bound to these heme groups CO suppresses their release, thus devoiding them from triggering CM (1). The same heme groups contained within cell free hemoglobin have been shown to scavenge endogenous nitric oxide (NO) and decrease its bioavailability, an effect shown to precipitate the onset of CM in mice (2). This suggests that as for CO, NO can also contribute to suppresses the development of CM. The central hypothesis to be tested under this proposal is that the protective effect of NO might rely on its well-established ability to induce the expression of heme oxygenase-1 and in this manner sustain the generation of CO. Once bound to the heme groups of cell-free hemoglobin, CO would inhibit heme release and in addition would increase NO bioavailability, thus generating a protective positive feed back loop in which NO would sustain the expression of heme oxygenase-1 and the generation of CO. Unveiling this functional interaction between NO and CO during Malaria infection might be useful not only to our understanding of the basic mechanisms underlying the pathogenesis of CM but also in developing ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evidence-based support for the design and delivery of user-centred online public services', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

eUSER supports the IST programme to achieve its key objectives to put the user and his/her needs at the centre of IST developments. It cuts across key public eServices domains - eGovernment, eHealth, eLearning - identified as priorities by the European Council and in the eEurope 2005 action plan, also priority area's in the IST work programme. eUSER addresses generic user-related issues and develops an accessible repository of evidence-based knowledge, methods and best practice examples. It pursues an extensive programme of active knowledge translation, transfer and dissemination supported by sophisticated online knowledge transfer tools. The knowledge base will consolidate both existing knowledge and approaches, and novel data generated by the project through representative population surveys (demand side) in all Member States, and through comparative analysis of readiness to address user aspects of public eServices in each Member State (supply side).Significant impacts will be achieved within the IST programme itself and more widely in the environment within which the programme operates. Support will be provided both at the overall programme level (strategic as well as detailed, evidenced-based operational guidance on user issues/priorities) and at the level of the individual RTD projects (help to better inform about and to address the specific needs of generic types of users at all stages of the project lifecycle, including requirements capture, design and development, and exploitation). The project will also provide robust benchmarking and prospective analyses that will be of value for the eEurope 2005 action and for EU public administration, public health and education policy. Finally, support will be provided to those who are practically involved in the design and