RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Granite and quartzite stone slabs processing by oxy-methane flaming' (1994-1998).

assistant: **Concept**

The proposed research project addresses the solution of a problem encountered in the industry of granite and quartzite slabs production; nowadays there is a strong market request of specially finished stones slabs (for functional, economic and aesthetics purposes) that are worked to obtain particular superficial roughness. The industrial systems for granite and quartzite slabs flaming, in the last decades, did not experience the same technologic improvements that followed instead by the equipment for stone cutting and working. To meet the market needs, a large number of machines for slabs flaming is needed, this implies high cost of investment and personnel, high cost of fuel and high rates of rejected slabs. The finishing of stones is performed by means of flaming their surface with high temperature jet flame to sputter the stone's splinters. The fuels and comburent used at the present are very expensive (compressed tetrane and propane, that are burnt with oxygen). The nowadays used torches are conceived for metal cutting and assembled on modified bushammering machines; the adoption of such empirical solutions reflects a poor quality of the surfaces and high rates of slabs rejected because breakage. An industrial research project is underway to develop improved systems, based on properly developed innovative blowpipes and nozzles, for the superficial working of stone slabs with a jet flame obtained from the combustion of the cost effective natural gas methane and oxygen generated on the site with the process of pressure swinging adsorption of the air. The major achievements expected from the project are :  The reduction of the costs of slabs processing. The aforementioned fuels can be replaced by the much more economic gas methane whose availability is guaranteed to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Boosting Agricultural Insurance based on Earth Observation data' (BEACON) targeting Horizon 2020.

assistant: **Abstract**

To objective of the BEACON project is to develop a commercial service package that will enable insurance companies to exploit the untapped market potential of Agricultural Insurance, taking advantage of innovations in Earth Observation, weather intelligence and ICT / blockchain technology. BEACON will enable insurance companies to alleviate the effect of weather uncertainty when estimating risk for Agricultural Insurance products, reduce the number of on-site visits for claim verification, reduce operational and administrative costs for monitoring of insured indexes and contract handling, and design more accurate and personalized contracts. Through an early warning service they will be able to inform their customers (farmers) for potential crop risks related with weather conditions, and advise them to take all the necessary actions to mitigate the impact of weather in their crops. EO data derived by Copernicus Sentinel missions as well as by missions contributing to Copernicus will be used to develop the data products that will act as a complementary source to the information used by insurance companies to design their products and assess natural disasters. Weather intelligence based on data assimilation, numerical weather prediction and ensemble seasonal forecasting will be used to verify the occurrence of a catastrophic weather event and to predict future perils. ICT / blockchain technology will be used for the smart contract service, to provide insurance companies with an automated method for paying out damages to insured parties. The BEACON services will be deployed in the operational environment of more than 10 companies in the insurance sector, openly demonstrating and validating its value proposition and acceptance as a marketable commercial solution. A business
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Targeted delivery of lipid nanoparticle-mRNA formulations modified with ligand pattern to dendritic cells based on DNA origami' in the context of a Horizon Europe call.

assistant: **Objectives**

mRNA vaccines have gained considerable attentions in prevention and treatment of virus infections, cancer and genetic diseases, especially in the application to the COVID-19 pandemic in recent years. Due to the immunogenicity and instability of mRNA, the in vivo delivery of mRNA plays a crucial role in vaccine efficacy. Among various materials, lipid nanoparticles (LNPs) have shown to be one of the most potent carriers for mRNA delivery and successfully enter the clinic. To further improve vaccine efficacy, dendritic cells (DC) uptake can be optimized by decorating mannose ligands on LNP-mRNA formulations for targeted vaccine delivery. However, the effect of ligand density, spatial distance and organization pattern on cellular uptake remains poorly understood. Due to the addressability of DNA origami, nanoparticles and small molecules can be spatially organized into prescribed pattern with nanoscale precision. Therefore, we propose to develop designed ligand patten on LNP-mRNA formulations by transferring ligand pattern distributed on DNA origami to LNPs. With ligands modified on surface, LNP-mRNA formulations will be used to investigate the effect of ligand pattern on DC uptake, which is not accessible to other targeted delivery system. The results of the project will promote the development of vaccine delivery field. In addition, it will influence the health care and biomaterial industries, which are central to Europe’s ongoing and future economic success.


**Keywords:** DNA origami, lipid nanoparticle, mRNA vaccine, drug delivery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A new technology for fluorescent cell chip" immunotoxicity testing"' under Fifth Framework.

assistant: **Concept**

Immunotoxicity is usually assessed employing well-defined animal models. Usage of transformed immortalized cell lines of desired phenotype is one of possible alternative for animal testing. There are evidences showing that at least certain types of immunotoxicity like these leading to hypersensitivity and autoimmunity are associated with modulation of expression of cytokine genes in immune or non-immune cells. This proposal outlines the development of technology for detecting xenobiotics-mediated modulation of cytokine gene expression in vitro. Specialized reporter cell lines will be prepared by genetic modifications to instantly detect signals modulating expression of cytokine genes. These cell lines will be tested and become a part of the cell chip. The prototype of a cell chip will be pre-validated as a system for testing immunotoxicity, and might be incorporated into a battery of screening tests.We have developed a new system for in vitro immunotoxicity testing, which employs changes in cytokine expression observed in vitro as an endpoint indicating potential for perturbation of the immune system in vivo. To this end a 30 different of DNA constructs designed in such a way that expression of reporter fluorescence protein depends of regulatory sequences derived from different cytokine genes were generated. These DNA construct including reporter vectors for IL-2, IFN-g, IL-4, IL-1b, TNF-a, and b-actin were employed for genetic modification of cell lines and resultede in development of a large collection of reporter cell lines. Upregulation of EGFP-mediated fluorescence upon stimulation with cell specific stimuli was observed in multiple reporter cell lines derived from lymphocytes, mast cells, keratinocytes and macrophages. Furthermore, this upregulation of EGFP expres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Integrated design simulation and distributed control of agile modular manufacturing machinery'.

assistant: **Concept**

The objective of VIR-ENG is to develop highly integrated design, simulation and distributed control environments for building agile modular manufacturing machine systems which offer the inherent capacity to allow rapid response to product model changes and feature variants. This acknowledges the need to compete effectively within a customer-driven market. The project seeks to achieve rapid introduction of new machine systems; rapid reconfiguration of existing machine systems when new products/models are to be introduced or process changes to be made; simplified and proven retrofitting with minimum disruption to accommodate minor design changes in the product, and rapid product change-over for redefined feature/model variants.The information infrastructure will be developed to facilitate a seamless integration between the machine system design environment and the control system design environment. Thus the code which is used to drive the simulation can be transferred/used in developing machine and application codes for the run-time operation of real machine systems. VIR-ENG adopts a distributed components-based paradigm for building machines and their control systems. At the conclusion of this project, an integrated virtual development environment will be available to support interactive visualisation, modelling, simulation and off-line programming of modular manufacturing machine systems. An integrated suite of development tools will be available for the configuration, programming, monitoring and analysis of distributed control networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The contribution of adipose tissue gene regulation to obesity-related pathogenesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Obesity is major challenge for healthcare worldwide and is linked to increased risk for type 2 diabetes and cardiovascular disease. However not all obese individuals are equally vulnerable and it has long been appreciated that central obesity (an excess of visceral fat) comprises a major risk factor for disease. It is also well established that adipose tissue from different parts of the body displays distinct biochemical properties, with biological profiles of subcutaneous and visceral fat being clearly distinguishable. It is likely that the biological mechanisms that govern these differences are, in part, responsible for rendering visceral fat a risk factor for disease. Given the need to understand the critical differences between adipose depots, the project I propose aims to identify key differences in the biology of subcutaneous and visceral fat, by addressing the fraction of genetic variants that contribute to this through a regulatory effect. To achieve this, mRNA will be extracted from subcutaneous and visceral adipose tissue from an initial sample of 50 individuals and will be sequenced using next generation sequencing. DNA will be extracted from lymphoblastoid cell lines from the same individuals and will be genotyped. Expression quantitative trait loci with an impact on cis gene expression will be identified through association of single nucleotide polymorphism genotypes with expression levels. Furthermore, chromatin will be extracted from subcutaneous and visceral fat from five individuals, and regions of open chromatin will be identified through formaldehyde-assisted isolation of regulatory elements. Integrating data on regulatory variation and open chromatin is an important way forward. This approach allows formulation of hypotheses regarding function outsid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a physiological simulator for cardiovascular devices' (CARDIOSIM), addressing dissemination and exploitation.

assistant: **Impact**

Heart disease is a major cause of death in the Western world. In the past three decades there have been a number of improvements in artificial devices and surgical techniques for cardiovascular disease; however there is still aneed for novel devices, espec ially for those individuals who cannot receive conventional therapy. The major disadvantage of current artificial devices lies in the fact that they cannot grow, remodel or repair in vivo. Tissue engineering offers the possibility of developing a biologica l substitute material in vitro with the inherent mechanical, chemical, biological and morphological properties required in vivo, on an individual patient basis.In order to develop a true biological cardiovascular device a dynamic physiological environment needs to becreated. The main objective of this research is to develop a physiological simulator capable of mimicking the in-vivo biological, biomechanical and biochemical conditions of the cardiovascular system in-vitro, to predict the biological and mecha nical response of conventional and novel tissue engineered cardiovascular materials invivo. In parallel computational modelling will be applied to predict local cell deformations and models generated will be correlated and assessed with experimental deform ations and biological responses. The results of this study if successful will represent a significant scientific breakthrough, paving the way for future generations of functional biological replacement materials, capable of restructuring and remodelling in -vivo. Thereby, offering the possibility of helping thousands of people who suffer from cardiovascular disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low-pressure turbines and control equipment for ave energy converter' in the context of a Fourth Framework call.

assistant: **Objectives**

The project proposal is prepared with the help of an Exploratory Award JO-ST-30 65 that include a Research Feasibility Study. The project objective is to de velop a technique where existing hydro turbines can be used in offshore wave en ergy converters (WEC) of the slack moored run-up type with some modification. T urbines and control equipment will be optimised for the use in the Wave Dragon - a 4 MW offshore wave energy converter. The European wave energy resource is v ery large, close to the coastline it is about 1000 TWh per year. Due to fact th at offshore WEC's could be placed in several lines with distances of 20 -30 km without loosing much efficiency because the wind generated waves are rebuilding their strength between the WEC lines, the recoverable resource (including mach ine efficiencies) is of the same magnitude. The resource is therefore not a re straint in the development of wave energy. The prime proposer has developed the Wave Dragon, and international patent application was published in 1996. This WEC combines known techniques in a new way that should lead to a competitive pr ice for the power production price from this renewable energy source, mainly be cause the capital and maintenance cost are small in comparison with the known d esigns of offshore WEC's. The design facilitates power production under North S ea conditions more than 95% of the average year. Low-head turbines of the cr oss-flow type and the Kaplan/propeller types have been in commercial use in hyd ro electric plants through decades and have an extremely long service life, but their working conditions are normally quite steady water flows and pressure he ads. The existing turbines and the control equipment are not suitable for use i n WEC's, because pressure and water flow are strongly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Foundation for Engineering Decentralized Self-Adaptive Software Systems' under Seventh Framework.

assistant: **Concept**

Software has a vital role in our society and the qualities of many software systems are of crucial importance. Examples are the availability of software for media and the robustness of software for manufacturing. Due to the ever-growing complexity of software, ensuring the required qualities constitutes a tremendous challenge. Self-adaptation has been widely recognized as an effective approach to manage the complexity and dynamicity of modern software systems. Self-adaptation endows a system with the capability to adapt itself autonomously to changes in its environment to achieve particular quality objectives. Despite substantial achievements in the field, major scientific and technical gaps must be addressed to deal with the progressing distribution and integration of software systems. In particular, existing approaches only support centralized or hierarchical control of adaptation. In a growing class of software systems, central control is not an option, e.g., large-scale sensor networks, integrated supply chains, and federated cloud infrastructures. The overall goal of this project is to study and develop a scientific foundation for engineering decentralized self-adaptive systems. Concretely, the project will study and develop: (1) a set of formally founded high-level design models for decentralized self-adaptation, (2) a set of supporting coordination mechanisms, and (3) an approach for formal analysis of decentralized self-adaptation that combines static with runtime verification. The focus will be on support for two important qualities of modern software systems: robustness and openness. To fundamentals will be applied to concrete applications in the robotics domain, and the research results will be validated in an empirical study. The applicant’s objective is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New procedure for the manufacturing of thin- walled PTFE pipes' to be submitted under Fourth Framework.

assistant: **Abstract**

This proposal has already been submitted to the European Commission under the proposal number BEST-2988. After the rejection message, all remarks and recommendations of the experts are considered. At the present time, there is no cost-effective procedure to produce thin walled PTFE pipes. Therefore the RTD goal of this project is to develop a new procedure which promise - an optimisation of the manufacturing time (reduction of more than 40%), - more economical use of the material consumption and - a reduction of the minimal wall thickness of less than 1 mm. The range of applications for thin walled PTFE pipes reaches from heat exchangers for incineration plants up to desalination systems for ships etc. Simultaneously with a reduction of the production costs the results of the research promise a decrease of the mass and a raise of the efficiency of the descripted aggregates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Twinning Laboratory for an Innovative, Global Hub To Explore the Deep' to be submitted under Horizon Europe.

assistant: **Abstract**

TWILIGHTED is a groundbreaking Horizon Europe Twinning project that seeks to revolutionize deep-sea research, development and innovation (RD&I) in Portugal, ultimately benefiting all of Europe. Collaborating closely with the esteemed European institutions of GEOMAR (Germany) and NTNU (Norway), TWILIGHTED aims to transform ARDITI (Madeira, Portugal) into a global hub for deep-sea RD&I. Focusing on the challenging Mesophotic Zone (40-200m) and the enigmatic Twilight Zone (200-1,000m), and capitalizing on Madeira's unique proximity to deep waters, TWILIGHTED will help accelerate our global understanding of the ocean and its essential role in sustaining life on earth.TWILIGHTED’s key objectives are to: (1) Collaborate across research institutes in Europe, (2) Elevate the research profile of Portugal and especially the European Outermost Region of Madeira, (3) Innovate low-cost alternatives to state-of-the-art deep-sea research technologies, (4) Democratize deep-sea research, (5) Globalize deep-sea RD&I and (6) Share ocean science across stakeholders.To achieve its objectives, TWILIGHTED will adopt state-of-the-art approaches to training and networking. Development activities include staff exchanges, expert visits, training schools, joint research missions, the International Twilighted Conference and novel cross-sector workshops stimulating creativity in solving the ocean’s greatest challenges (the Impossible Things Workshops). Such capacity-building will not only catalyze deep-sea RD&I in Madeira, but ensure a lasting impact on the deep-sea scientific landscape, sustainable ocean policy and Madeira’s socioeconomic development.TWILIGHTED marks the start of a transformative journey for Portugal, redefining its role in understanding and protecting vital deep-sea ecosystems. TW