RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Morphostasis of the intestinal mucosa and it's deregulation in cancer and inflammation'.

assistant: **Innovation**

Stem cells at the base of the intestinal crypts are in a dynamic equilibrium with their differentiated derivatives. Homeostatic equilibria depend on the presence of negative feedback loops. The role of the Wnt signaling pathway as a driver of epithelial stem cell self renewal and proliferation in the intestine has been relatively well characterized. Much less is known about the negative feedback signals that must exist to control stem cell behavior and the way these may be deregulated in disease. We found that Indian hedgehog is secreted by differentiated intestinal epithelial cells and acts as a negative feedback signal. Hedgehog signaling acts as a break on Wnt signaling in intestinal precursor cells via a secondary signal in the mesenchyme. We will use conditional mutant mice, our large biobank of patient materials and in vitro experiments to further characterize the signals involved in this feedback loop. Our objective is to study the role of this epithelial mesenchymal signaling circuit in the normal intestine and examine the way it is deregulated in intestinal cancer development and inflammation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Optimal Lightning Protection System'.

assistant: **Innovation**

EU has set the goal that 20% of our energy should come from renewable sources by 2020. The impact of lightning strikes on wind turbines has long been an issue for the industry. Already in the technical report from IEC published in 1998 (IEC TR 61400-24) blade damages was contributing with the highest repair cost, and the longest outage time. This tendency has continued the last decade, where the blade lengths have increased from 20-30m to blade lengths of 60-80m. Specifically, lightning-related failures and consequent maintenance and repair activities is the primary cost in operating wind turbines, for instance a lightning strike offshore can cost up to €1.5 million when accounting for the expenses related to crane vessel, offshore repair operations and loss in energy production.Currently, all OEMs implement lightning protection systems (LPSs) in their blades. However, laboratory experiments and field experience often find these protection systems inefficient. This has drastic economic consequences for wind farms owners/operators. The Opti-LPS project mitigates this problem by developing an innovative new blade agnostic LPS product, increasing the protection efficiency (interception and lightning current conduction), lowering the costs of the LPS system, and greatly simplifying the installations and logistics compared to recent solutions seen at many manufacturers. The consequence is a lowering of initial costs and servicing that ultimately increases the economic feasibility of wind turbines.The innovation project will bring the Opti-LPS closer to market by design optimisation, work flow optimisation and demonstrations using prototypes.The feasibility study comprises of: a market study, feasibility of technical and economic factors and development of a business plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prisoners of war between Bourbon nations and United Kingdom during the 18th Century: ways of life and humanity in misfortune' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Armies of the Ancien Régime reflected not only the society of their time, but also the politics, importance and international weight of their respective nations. Prisoners of war offer a privileged insight into these issues and, more significantly, into the human and humanitarian feelings of all those involved, politicians and civilians as well as the military. This study will provide a ground-breaking comparative approach to prisoners of war from Britain, Spain and France during the long 18th century. Through correspondence written by the prisoners themselves as well as letters to/by the authorities, we will chart feelings and views towards the conflicts from those directly involved, revealing alternative views of war than those imposed by their sovereigns. In what the prisoners conveyed to their families and to the authorities, we can learn much of the conditions of captivity, which varied considerably depending on religion, social status or military rank. Across the century, we find analogous prisoner of war experiences  in different societies and historical periods, but after the French Revolution significant differences begin to emerge because of new political considerations which meant qualitative changes to the status of prisoners of war, since they were henceforth political prisoners, no longer Ancien Régime ones. Comparing Britain and Spain with France is essential to perfecting our understanding of how the status and experience of prisoners of war changed between the old order and the new. In brief, this is a study that helps to understand better the changes in the humanitarian measures in war which form the basis of current practice and are at the heart of notions of Human rights.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'OutMARCH-ing cancer: Towards innovative membrane protein degrader modalities for cancer treatment' (OutMARCH) under Horizon Europe.

assistant: **Objectives**

The OutMARCH project pioneers a paradigm-shifting protein degradation technology aimed at transforming the therapeutic landscape for cancer and beyond. By engineering a novel class of bispecific antibodies—SureTACs—that harness membrane-bound E3 ubiquitin ligases to selectively degrade disease-driving surface proteins. This groundbreaking lysosomal-targeting approach offers greater selectivity, durability, and breadth than conventional blocking therapies and, moreover, enables the targeting of previously 'undruggable' proteins. Central to our innovation is the utilization of the MARCH family of membrane-bound E3 ligases—an unconventional class of enzymes with remarkable substrate promiscuity and cancer-selective expression profiles. These properties make MARCH E3s ideal effectors for tissue-specific protein degradation, reducing off-target toxicity and overcoming treatment resistance. To unlock their therapeutic potential, we will develop a modular platform combining antibody engineering, innovative screening technologies, and machine-learning-guided design. The result will be a new class of biologics that direct the body’s own cellular machinery to dispose of harmful proteins.Our initial focus is on two urgent oncology needs: therapy-resistant B-cell lymphomas and difficult-to-treat gastrointestinal cancers. Both cancer types rely on critical cell surface signaling hubs that evade traditional drug targeting. By degrading cancer-driving proteins at the cell surface, we aim to drive tumor-specific protein elimination to achieve durable anti-cancer effects. Using AI-guided antibody design and optimized E3-target pairing screens, OutMARCH will establish the first programmable, modular membrane degrader platform. While currently focused on oncology, this platform has broad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Enhanced Access to System Integration Technologies'.

assistant: **Objectives**

The project will provide enhanced access to advanced subsystems integration technologies. Potential users will be served by a network of regionally distributed technically knowledgeable Service Centres which can guide them through every step from first awareness of technology capability through prototyping to volume production. Three complementary supply networks of manufacturers will be maintained: for component supply; prototyping; and volume production. Users will be reached by Europe wide awareness and dissemination activities including exhibitions, seminars, workshops and newly developed training courses. Users will then be encouraged forward by support from Service Centres, which will be increasingly self-funded and provide advice on choosing technology, vendor and design route.Objectives:Provide access to a network or manufacturers for prototypes, low and high volume production of advanced subsystem integration technology and components. Speed up design access by delivering design kits on multiple technologies from several manufacturers, which work to a common format. Maintain a wide technology base but driven by the strategic needs of European industry. Strengthen existing support organisation networks by providing information and training on advanced technology so that users can find local/regional expertise. Speed up the learning curve for take up of technology by developing training courses for advanced technology.Work description:EASIT will build on the infrastructure created during the EUROPRACTICE MCM PROJECT. The supply network will be strengthened by the commercial company Inpact taking over the high volume production network and the other EASIT partners building a network, which focuses on prototyping and low volume supply for a broader range of technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'REVEALing Signatures of Habitable Worlds Hidden by Stellar Activity', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

For millennia people have wondered, “Do other Earths exist?” “Are they common?” “Would they show signs of life?”. We now have the technical capability to answer these questions. New radial-velocity spectrometers are capable of detecting the reflex motions of stars hosting Earth-mass planets in their habitable zones; the James Webb Space Telescope has the power to probe the atmospheres of rocky exoplanets. Yet the unprecedented precision of these instruments’ measurement capabilities is up against a fundamental astrophysically-imposed barrier to achieving these goals: contamination of exoplanetary signals by stellar activity and variability. Further progress is contingent on solving this “variability problem”.REVEAL gathers world-leading experts in exoplanetary and stellar physics to tackle this problem in synergy:- We will build on recent advances in magnetohydrodynamic simulations of stellar atmospheres, and data-driven efforts to separate the exoplanet signal from the stellar variability.- We will simulate the “ground truth” of the turbulent physics of entire stellar photospheres resolved at the level of individual convective cells for a broad class of stars.- We will model the emergent spectra of these “virtual” stars and “observe” them using the same data-processing pipelines as stellar radial-velocity and transit-spectroscopy observations.We will continue to observe the Sun and stars hosting small planets found with TESS and PLATO. The stars’ own spectra will REVEAL the clues needed to disentangle stellar variability from our measurements of their planets’ masses and the fingerprints of molecules in their atmospheres. Our unified efforts will enable the new cutting-edge space observatories and ground-based facilities to realize the full potential of their designs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Experimenting Acoustics in Real environments using Innovative Test-beds' (EAR-IT).

assistant: **Concept**

Audio sensors are cheap and often easy to deploy and, with the growing power of processing and networking capabilities it is possible to exploit audio data for a broad range of applications. The untapped value of audio data is still to be revealed but key partner in this project are already working on energy efficiency and traffic monitoring applications, just to mention few. There is thus great potential for RTD on intelligent (acoustic) solutions based on acoustical sensor networks to support a myriad set of applications of high (social, business, etc.) value.On the other hand, there exist now large-scale innovative test-beds to support experimentally-driven research on 'real-life' environments – the FIRE facilities! These facilities (notably here, SmartSantander and HobNet) have an installed base of sensors, networked altogether, capable of supporting some advanced research in intelligent acoustics solutions. This leads to the idea of Ears on FIRE" directed at Experimenting Acoustics in Real environments using Innovative Test-beds (EAR-IT) by realising some distributed intelligence powered by acoustics.To explore, validate and confirm the RTD possibilities of using audio data both in indoor and outdoor environments, this project will use then use nice test-bed capabilities of the HobNet project for indoor environment and related application such as energy efficiency, as well as the capability of the SmartSantander project for large-scale outdoor but also indoor environments where applications can be useful in a smart city environment. The objectives will be both to validate main research lines but also to deliver new innovative range of services and applications targeting (but not limited) to smart-buildings and smart-cities."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Future perspectives of co2-removal at power plants in europe (DELPHI CO2-REMOVAL)' under Fifth Framework.

assistant: **Concept**

According to the Kyoto protocol, CO2-emissions have to be reduced in Europe. Electricity production will depend heavily on coal and natural gas in the next decades. In underlying proposal is described the exploration of the communal wisdom" of 400 experts with various backgrounds regarding the future perspectives of the CO2-removal at power plants in the next 10-15 years in the EU. Besides general trends, country specific characteristics will be investigated. The study will be based on the "Delphi method ". Every next questioning round the panel members are allowed to use statistical information about the response in the previous rounds. Based on this, the feasibility of and needed conditions for CO2-removal will be found and a Strategy Paper until 2015 will be made for CO2-removal. The EC can use this when developing new policies."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Attempts to Control the End of Life in People with Dementia: Two-level Approach to Examine Controversies' (CONT-END).

assistant: **Concept**

In dementia at the end of life, cognitive and physical decline imply that control is typically lost. CONT-END will examine control in the context of three emerging interventions which contain a controversial element of striving for control in the process of dying with dementia: advance care planning of the end of life, use of new technology to monitor symptoms when unable to self-report, and euthanasia. To perform outstanding research, the proposed research examines control at the level of clinical practice, but also at the level of end-of-life research practice. The latter provides ample opportunities for researchers to control the research process. That is, research designs are often flexible and we will study if and how this impacts research in an emotionally charged area. I will take an empirical mixed-methods approach to study the two practices in parallel. The work is organised in three related Work Packages around three research questions. (1) In a 6-country study, I will examine if and when people with dementia, family caregivers and physicians (900 respondents) find the interventions, shown on video, acceptable. (2) A cluster-randomised 3-armed controlled trial in 279 patients and their family caregivers assesses effects of two types of advance care planning differing in level of control (detailed advance treatment orders versus goal setting and coping based) on outcomes ranging from favourable to less favourable, and whether effects differ in subgroups. Cases in which the technology is preferred or applied are observed. (3) Ethnographic fieldwork in two different end-of-life research practices and a Delphi study to synthesize CONT-END’s findings assess how researchers shape findings. This greatly improves the quality of CONT-END and provides the input to devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New era of guided lens implantation in cataract surgery', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

AkknaTeks device-based solution is introducing a unique imaging technology to overcome the current hurdles of nowadays cataract surgery. It is designed to offer full control over the lens position at any point of the treatment; for the first time guaranteeing best possible results for every lens implanted. The solution consists of a set of 3 modules which also can be used independently. Pre-operatively, the diagnostic system for patient screening allows detection of capsular bag dislocation, calculates the optimum lens design and eliminates IOLs not suitable for the respective patient to reduce the need for potential re-surgery right from the start. During the surgery, the image-guided system enables real-time monitoring of the IOL placement and computer assisted guidance to ensure accurate placement based on the visual axis. After surgery, the post-operative diagnostic system measures the IOL position and, if needed, helps the surgeon re-align the IOL, as it may move after surgery.


**Keywords:** Cataract surgery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'High temperature superconductivity and the Catch-22 conundrum'.

assistant: **Objectives**

CATCH-22 sets out to resolve the mystery of the cuprate high temperature superconductors. Hailed as one of the major discoveries of the 20th Century, its central mysteries – the pairing mechanism, the origin of the ‘pseudogap’ and the nature of the ‘strange metal’ phase, have remained elusive for over 30 years. Typically, what scatters electrons also binds them into pairs, and in the cuprates, the strong pairing interaction manifests itself in the strange metal phase as intense scattering, so strong in fact that it drives the electronic states required for pairing incoherent. In other words, what first promotes high temperature superconductivity ultimately destroys it! This logical paradox is the Catch-22 conundrum. CATCH-22, the program, comprises three parts. Part 1 will explore the fate of electronic states within the strange metal phase by studying how the metallic response diminishes across universal bounds, both as a function of temperature and interaction strength, through momentum-averaged electrical conductivity and thermal diffusivity studies and momentum-resolved photoemission spectroscopy. Part 2 will seek to access the ground state of optimally doped cuprates for the first time, by applying intense current and laser pulses to ultra-thin samples in a high magnetic field. The latter, if successful, will open up a new frontier in which intense THz light and intense magnetic fields combine to access the terra incognita of hidden phases. Finally, Part 3 will explore the origins of the strange metal at the edge of the superconducting dome and search for manifestations of incoherence in other strange metals in an attempt to unify the governing principles. Given that the central mysteries are intertwined – the strange metal is a precursor to the pseudogap which in