RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intramitochondrial seeding and sorting of protein aggregates' (INTEGRATE).

assistant: **Innovation**

Quality control processes maintain mitochondrial health, enabling cellular functions such as bioenergetics, metabolism, Ca2+ signaling, and cell death regulation. Mitochondrial proteases, unfolded protein response, asymmetric fission, vesicle shedding, and mitophagy all contribute to organelle quality. However, the specific triggers for these processes remain unclear. While unfolded protein accumulation appears to be a common trigger, the mechanism by which it initiates diverse responses remains uncertain.To investigate this question, we developed advanced tools for real-time imaging of protein aggregation in mitochondrial subcompartments. Aggregates in the matrix and intermembrane space induce mitochondrial fission and elicit distinct functional responses based on their location. Live imaging revealed that intermembrane space aggregates initially seed in the mitochondrial midzone and then sort through transient side-by-side fusion with neighboring mitochondria. In the matrix, aggregates seed at one pole and are selectively sorted to daughter mitochondria through asymmetric fission. Our preliminary experiments unveiled an early seeding and sorting process of protein aggregates according to their intramitochondrial location.In the INTEGRATE project, we aim to comprehensively understand the underlying principles and consequences of this process. By combining advanced imaging techniques, omics analysis, biochemistry, functional assays, and unbiased screenings, we will decipher the rules governing aggregate formation, seeding, sorting, cellular fate, and response in various mitochondrial subcompartments.INTEGRATE seeks to establish the occurrence and downstream responses of this newly discovered early phase of mitochondrial quality control. Clarifying this fundamental mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Video-rate Scanning Probe Microscopy Imaging  of Nanostructures on Surfaces' (VIN), addressing dissemination and exploitation.

assistant: **Impact**

The goal of this ERC proposal VIN is to develop the next generation of scanning probe microscopes (SPMs) The microscopes will set new standards in the field through their ability to acquire images at video-rate frequency, while retaining high (atomic) resolution capability. This new instrumental platform will be implemented both under ultra-high vacuum conditions, in a high-pressure gas cell, and under liquid-phase conditions. It will be utilized to create and explore novel research avenues for the study of physical, chemical, and biological surface processes at the single-atom/molecule level with the highest possible spatial and temporal resolution. In particular I will study dynamic phenomena in surface nanostructures, focusing on three mutually synergetic and interdisciplinary priority areas: i) Catalytic reactivity of nanostructures, ii) Self-organisation of organic molecules at surfaces, iii) Biomolecular structures, processes and interactions under physiological conditions. The adsorption, diffusion and interaction of molecules are the basic steps involved in reactions at surfaces. All of them are dynamic processes, where high temporal resolution can provide new groundbreaking insight into e.g. the mechanisms underlying catalysis. Video-rate SPMs will also facilitate investigations of the kinetic aspects of molecular self- organisation at surfaces such as diffusion, intra-molecular conformational dynamics, nucleation and growth of structures. The effort will build upon the world-leading expertise in design, construction and use of SPMs in my research group at the Interdisciplinary Nanoscience Center (iNANO) and the Department of Physics and Astronomy, University of Aarhus, Denmark. To achieve the ambitious research goals, I will bring together an interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ERA-NET Biomarkers for Nutrition and Health implementing the JPI HDHL objectives' (ERA-HDHL).

assistant: **Innovation**

ERA-HDHL is a proposal of ERA-NET Cofund in the field of nutrition and health to support the Joint Programme Initiative Healthy Diet for a Healthy Life (JPI HDHL).Nowadays, there is a high burden of non-communicable diseases due to unhealthy diet and lifestyle patterns. The 24 members of the JPI HDHL are working together to develop means to (1) motivate people to adopt healthier lifestyles including dietary choices and physical activity, (2) develop and produce healthy, high-quality, safe and sustainable foods and (3) prevent diet-related diseases. Between 2012 and 2015, JPI HDHL had implemented 7 JFAs with 40 M€ funds from national funding. The JPI HDHL is now set for further enhancement in tight coordination with the EC through the ERA-NET Cofund instrument. ERA-HDHL will provide a robust platform for implementing joint funding actions (JFAs) that address the needs identified in the JPI HDHL strategic research agenda and strengthen the research funding activities of JPI HDHL. An EC cofunded call on the identification and validation of biomarkers in nutrition and health will be implemented. For this foreseen action, the member countries of the JPI HDHL have doubled their financial commitment comparing to previous JFA implemented on a similar topic. Moreover, ERA-HDHL will launch at least 3 additional JFAs in line to fulfil the JPI HDHL objectives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Oxetane amino acids- towards new artificial antibiotics and biopolymers' in the context of a Fifth Framework call.

assistant: **Objectives**

Carbohydrate scaffolds offer a large family of monomers with the ability to tune predisposition towards specific secondary structures. This project will investigate the potential for conformational control in small molecules by four membered (oxetane) rings. This project will study the efficient synthesis of monomers containing oxetane moieties, both as didpetide isosteres and as beta-amino amino building blocks.This will involve synthesis of monomers, well-defined preparation of ecologically friendly biopolymers, together with structural studies to determine the outcome of the synthetic work. Collaboration will include the incorporation of oxetane determinants into combinatorial libraries. Preliminary modeling shows that four ring structures are likely to be the best frameworks for the control of secondary structures in short sequences. There have been no reports of the use of four membered rings to control structural features.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advancing scientific performance and regional potential of Estonian biomedical research' to be submitted under Seventh Framework.

assistant: **Abstract**

Growing pressure of environmental and socio-psychological factors in modern society burdens our main host defence organ systems, neural and immune system, with a number of serious consequences. Therefore the understanding of the function of these two systems as well as the mechanisms of neurological and immunological disorders is our major challenge in biomedical field.  With that in mind, the Centre of Molecular and Clinical Medicine of University of Tartu has set to its general mission to raise the level of Estonian medical research and to concentrate the skills and funds to selected cutting-edge areas of medical research, neuro- and immunological sciences. Current application is aimed to provide support for these scientific activities: the overall aim of current project is to advance the RTD performance and the quality of research in neuroscience and immunology carried out by the Centre of Molecular and Clinical Medicine at University of Tartu.  Fulfilment of this overall aim requires several key measures that enhance the existing dynamic environment and collaborative links within the Centre and with other institutions in neurological and immunological research: short term visits of our staff (WP1), recruitment of incoming researchers (WP2), improving the Centre’s infrastructure (WP3), transfer of knowledge via workshops and conferences (WP4) and increased public visibility within the economic and social environment of Estonia (WP5). We are sure that this will raise the Centre’s research potential and helps us to provide high quality research for society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unraveling the persuasive power of 360º-video Virtual Reality narratives' (PersVR).

assistant: **Concept**

Raising awareness and comprehension of global problems such as climate change or refugee movements provides a communicational challenge, as these problems often stay abstract and distant to people. With the advent of virtual reality (VR), academics and journalists alike put their hope in 360º-video VR stories as a potentially revolutionary tool to create scenarios that make these problems more graspable, thus raising concern and instigating attitude-change. However, to date, empirical insight into potential persuasive effects of 360º-video VR stories is almost absent, and theoretical conceptualizations of how they might impact people are lacking. PersVR is going to change this. The aim of PersVR is to overcome these shortcomings, and to demonstrate if and how immersive journalism and documentary focusing on 360º-video VR might affect people’s beliefs, attitudes, and behavior. The project adopts a multidisciplinary perspective that integrates knowledge from different fields (including social psychology, communication sciences, and psychophysiology) into a theoretical model that describes how narrative and immersive attributes of 360º-video VR lead to persuasive outcomes. The empirical testing of the model will utilize an innovative combination of self-report, psychophysiological, and behavioral methods to comprehensively illuminate the psychological mechanisms involved. The complex set of methods deployed will permit to determine optimal methodological standards that promise to guide future related studies. The current rise of “immersive journalism” and VR storytelling accentuate the high relevance, timeliness, and expected impact of the project. The innovative approach of the project and the envisioned collaboration with the host will provide the applicant with a unique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The hydrocup: a hollow electrospun scaffold for in vivo cell-laden hydrogel delivery' (HYDROCUP) under Horizon Europe.

assistant: **Objectives**

Secreted cytokines by transplanted cells can have positive effects such as immunomodulation, angiogenesis and tissue regeneration. However, transplanted cells are difficult to retain in a specific place to maximize the release of cytokines on site. Here, we developed a hollow electrospun scaffold with one open and one closed end for the in vivo delivery of cells as ?secretory factories? in a hydrogel, termed the hydrocup. Because of the closed end, a (cell-laden) hydrogel can easily be dispensed into the open end of the hydrocup, after which the open end is closed with sutures. As part of the ERC starting grant where this application stems from, we showed that adult stem cells encapsulated inside the hydrocups remained viable for 28 days in vitro and released functional cytokines similar to hMSCs in hydrogels alone. In addition, the hydrocups remained intact and fixed in place for 6 weeks after subcutaneous implantation in rats. In this ERC proof of concept proposal, we aim at further studying the hydrocup as a device for a wide variety of cell-based cytokine secretion or drug-laden hydrogel applications. We will further refine the device for applications in the cardiac regeneration market where stem cell based therapies suffer so far from low viability of cells after injection. We will make a market analysis study of competitors in the cell therapy field and propose an initial business plan for seeking further investments to create a spin-off company at the end of the grant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Design and Synthesis of MXene-Based 3D Porous Heterostructure Composites for Enhanced Photocatalytic  Ammonia Production Under Ambient Conditions for Sustainable Hydrogen Energy Storage' (Bezzagood) under Horizon Europe.

assistant: **Objectives**

While hydrogen is an excellent green energy carrier, which holds tremendous potential as a sustainable, environmentally friendly, efficient, and clean energy alternative, its storage remains costly, energy-intensive, and hazardous. Recently, the possibility of chemical storage of H2 in the form of ammonia (NH3) is receiving increasing attention. However, despite the potential of NH3 for hydrogen storage the existing fossil fuel-based NH3 production technology is highly energy intensive and costly. Photocatalytic NH3 synthesis is gaining familiarity as it is environmentally benign and sustainable, however, the conventional photocatalysts suffer from low NH3 yield, poor photocatalyst operational stability, and low solar-to-chemical conversion efficiencies, thus it is the current scientific challenge to design an efficient photocatalyst to convert atmospheric N2 to NH3. Hence, the design and construction of novel hybrid photocatalysts with enhanced photocatalytic performance is vital for efficient synthesis of ammonia as a hydrogen energy storage medium. In recent years, the two-dimensional transition metal carbides, carbonitrides and nitrides ( MXenes), are gaining popularity for photocatalytic N2 reduction owing to their diverse elemental compositions, large surface area, light-harvesting ability, and capability to host a broad range of intercalants. Besides heterojunction formation by combination of MXenes with 3D reduced graphene oxide (rGO) and other novel photocatalysts such as MetalOrganic Frameworks, Z-scheme photocatalysts would significantly increase photocatalytic performance of the hybrid by combining the merits of each component. Besides the interconnected structure of 3D rGO framework possesses a macroscopic porous structure, for efficient incorporation of se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SecUring sPORTs Education thRough innovative and inclusive Gender Equality Plans' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

SUPPORTER advances inclusive gender+ equality within the ERA. It supports institutions to develop intersectional, innovative, inclusive and impactful gender equality plans (4I-GEPs), tailored to sports higher education institutions, and explicitly addressing gender-based violence including sexual harassment (GBV). Building on state-of the-art knowledge and the expertise of advanced gender+ equality institutions, SUPPORTER co-creates an innovative capacity-building and mutual learning programme, delivering support and mentoring towards the development of the 4I-GEPs.Guided by inclusive and innovative epistemologies and co-creative methodologies SUPPORTER acts:  -horizontally, by fostering institutional capacity and culture based on the principles of Diversity & Inclusion within an intersectional framework, ultimately enhancing the sports institutions’ reputation, attractiveness, inclusiveness and research excellence; -vertically, by triggering a transformative, institutional inclusive and sustainable change to sports institutions to address inequality-driven challenges and advance gender+ equality, focusing on GBV, thus also enhancing the institutions’ efforts towards meeting their gender+ equality objectives in the ERA context.To achieve these objectives SUPPORTER adopts a twinning-inspired approach, methodologically based on 3 interlinked processes (analytical, reflective, implementation), combining 4I learning and mutual learning schemes with co-creation and dissemination activities, engaging a diverse range of stakeholders, and building on knowledge and expertise from previous projects and tools.The multiplier effect of SUPPORTER, starting from the eight partner institutions and gradually reaching the sports ecosystem, has the long-term potential to trigger gender+ i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scale of governance, the UN, the States and Indigenous peoples human rights: the meanings and issues of self-determination in the time of globalization' under Seventh Framework.

assistant: **Concept**

This proposal describes a multi-scale research project investigating the social, cultural and political issues relating to governance and Indigenous Peoples. Recent international mobilization has led to a major shift, culminating in the adoption by the UN of the Declaration of the Rights of Indigenous Peoples (UNDRIP) in 2007. This highly symbolic and moral document is expected to induce changes and to combat discrimination. Indigenous peoples have acquired visibility, as models of sustainability and for their ecological knowledge. Yet their place in constitutional orders, their participation in decision-making, and their development practices have not been consistently studied. Crucial issues include their emergence as political actors, the role of transnational networks, and convergences in two sectors of global concern - human rights and the environment. The UNDRIP opens room to consider the various modalities of self-determination. A comparative approach will help get rid of simple dichotomies, while putting at the centre of the scientific debate the modernization of the Western discourse and the post-colonial theories. With the PI, a team will study the changes that international norms induce through the development of programs, EU initiatives too, and the response at local levels. The research will focus on arenas in which indigenous communities are confronted by modern policies: education, land management, political representation, legal systems and the expression of culture. 10 comparative studies will be undertaken, in Southern Africa, South America, Asia and Oceania. Key findings will be discussed through thematic and regional workshops; dissemination done through seminars and publications. The UN Permanent Forum for Indigenous Issues has repeatedly requested
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CEZAMAT-Environment - Self-Organizing Networks for Real-Time, Wireless Monitoring of Natural Environment' (CEZAMAT-Environment).

assistant: **Concept**

This Proposal aims to establish a new research Center of Excellence named CEZAMAT-Environment devoted to the fundamental study and practical implementation of self-organizing networks of chemical and biochemical sensors capable of massively parallel and spatially distributed sensing of environmental hazards and other parameters defining the status of natural resources (e.g., forests, or agricultural crop, aquatic ecosystems).The objective of the one-year action (covered by the CSA) is the development of a detailed and robust Business Plan for the setting-up the Center capable of attaining this long term vision.The goal will be achieved through joint management by the Teaming partners, i.e. The National Centre for Research and Development (Poland), CEZAMAT PW Sp. z o.o. (Poland), CEA-Tech (France), Fraunhofer-Gesellschaft (FhG, Germany), the two latter being Partners of Excellence.The Proposal responds to the work program “Spreading Excellence and Widening Participation,” which aims to reduce internal research and innovation disparities within the European Union by supporting research and innovation activities and systems in low performing countries. The Proposal addresses a specific challenge defined by the work program – namely, the presence of substantial disparities in the European Research and Innovation landscape, and also aims at establishing long-term and strategic partnership between Teaming partners. In the short-term perspective, we will actively seek the advice of the Partners how to best implement the operation and administrative protocols within our Center, especially how to foster cross-discipline collaboration while staying focused on the short-term milestones and long-term goals. In the long-term perspective, the Center will implement within its own stru