RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High-temperature stable nano-structured silicides for highly efficient thermogenerators and their contacting technology' (NANOSICON).

assistant: **Innovation**

Deficiency of natural energy resources on Earth makes advanced energy management a challenge. Efforts are taken to harness cheap, inexhaustible, eco-friendly renewable sources of energy. Among these, thermoelectric (TE) conversion is a promising principle. Best materials for TE application are non-conventional heavily doped semiconductors. In particular, high temperature stable silicides (higher manganese silicides = HMS, CrSi2 and others) represent suitable candidates for demanded TE applications operable at high temperature. A main aim of TE materials development is to improve the figure of merit ZT, which essentially depends on the energy band structure and scattering of carriers and phonons in the material. It is planned to investigate qualitatively the transport behaviour of HMS compacted from nano-sized powders, to optimize its properties by chemical synthesis, and to reach a reduction of the thermal conductivity in nano-crystalline material. Starting from the synthesis of nano-powders by melting and ball milling, forming of a nano-structure with suitable scaling will be optimized by a rapid hot pressing technology. CrSi2 and other high temperature silicides will be optimized in a similar way for high electrical and thermal conductivity. They shall be applied as contacting materials and interlayers, ending up to advanced materials and technology procedures for high temperature thermogenerators. Materials will be characterized by XRD, SEAD (structure), TEM, SEM (morphology), EDAX (analysis). Having achieved the targeted nano-structure, the TE properties will be measured in dependence on temperature for optimising the application-relevant material parameters. The performance of thermogenerator devices based on the new solutions will be tested by unique measuring tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CO INTEGRATION OF MICROELECTRONICS AND PHOTONICS FOR AIR AND WATER  SENSORS' (COMPAS) targeting Horizon Europe.

assistant: **Abstract**

The main objective of COMPAS is to develop a compact, inexpensive and ultrasensitive PIC sensing platform (PSP) for air and water monitoring, relying on the co-integration of light source, detectors and electronic IC for on-chip signal processing.The PIC sensor principle will be based on interference between two guided light modes, one of which interacts with analytes and the other being a reference. The resulting intensity changes offers excellent sensitivity to changes in concentration of analytes in air or solution. Multiple light paths can be placed on the same device offering multi-analyte sensing in an ultracompact device. COMPAS builds a first-of-a-kind fully integrated system around this principle (including light source, detectors and signal processing). The COMPAS PSP begins at TRL2 and will end with TRL5 validation in relevant environment by end-users towards air and water monitoring. The project will -Define sensing parameters for validating developed PIC Sensor Platform (PSP) towards three use-cases in relevant environments, being in line with the European Green Deal’s zero pollution ambition -Develop core photonic technology for implementing photonic based sensing. These include a novel photonic IC material system (Aliminium Nitride),  BiModal waveguide interferometers that show superior temperature stability and sensitivity, novel material coating systems for enhanced sensing selectivity and innovative nano structured metasurfaces for novel mode engineering for increased sensitivity and optimized light coupling to facilitate the use of low power laser diodes.-Develop a Chiplet approach to co-integration of photonic sensor with microelectronic IC and photodetectors, and a coherent light-source. This will combine heterogeneous integration of a laser light s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Paleogeography of the Paratethys: Relation to hydrocarbon source rock quality' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Neogene Paratethys successions of Central Europe and the southern Caucasus are considered as important source rocks for hydrocarbons. Due to different regional biostratigraphic stages used for potential source rock successions, paleoenvironmental correlations remain enigmatic and hydrocarbon source rock formation is poorly understood. The goal of this project is to reconstruct the Eocene to Miocene paleogeographical and environmental evolution for the Central and Eastern Paratethys in the framework of forcing contributions of tectonics and climate.To accomplish this goal, the marine and estuarine successions of the Maikop series of the Greater Caucasus, the Tard Clay of the Pannonian Basin,  the Menilite Shales of the Carpathian Foredeep, the Bulgarian Ruslar Formation, and of the Alpine Foreland Basin will be studied using a multidisciplinary research approach. This approach includes:(1) Combining biostratigraphic data with a variety of geophysical, geochemical, stable isotope (C, N, O), and organic (Rock-Eval) analyses(2) Detailed characterization of the molecular composition of organic matter (e.g. maturity, facies, origin) in source rocks and hydrocarbon reservoirs(3) Compound-specific C-isotope analyses on biomarkers; H- and C-isotopic composition of oil and gas(4) Basin models for hydrocarbon generationThe results of this approach will allow to constrain the influence and interaction of the controlling factors on changes in biological communities, water exchange and formation of natural resources in intra-continental basins. Reconstruction of the thermal evolution of hydrocarbon source rocks and of charging events will enhance our understanding on the pre-conditions and generation of petroleum deposits within the prospective areas. The results are expected to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards gene identification and personalized prophylactic medication for lithiopathies in lithium-using patients' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Lithium is widely prescribed and the mainstay treatment for bipolar disorders. Unfortunately, lithium treatment often leads to adverse side effects (lithiopathies) like hypercalcaemia, nephrogenic diabetes insipidus and chronic kidney disease.Despite the above lithiopathies, cessation of lithium therapy is not an option for most patients, because there is no good alternative and the bipolar disorder has a larger impact on the patient’s quality of life. However, rationally-based medication for lithiopathies exists. As the lithiopathies are largely irreversible, the medication should be administered with the start of lithium treatment. However, prophylactic administration of these medications to lithium-using patients is undesirable, because not all patients develop lithiopathies. Therefore, to target for lithiopathy-specific personalized prophylactic medication for lithium-using patients, the aim of this study is to identify the susceptibility genes for development of the lithiopathies.To identify these susceptibility genes I propose to employ state-of-the-art haplotype association mapping (HAM) with mice at a world-recognized expertise centre for genetic research. As the used inbred mouse strains are fully genotyped, produce genetically identical offspring, and develop the lithiopathies consistently and on short term, HAM has clear benefits over genome-wide association studies in humans. At the return host, the role of identified susceptibility genes will be confirmed in cell and animal lithiopathy models and the corresponding orthologous genes in lithium-using patients will be tested for association with the lithiopathies. The project will not only provide the first steps towards personalized prophylactic medication for lithium users, but is also the perfect setup for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Who gets to live forever? Toward an Institutional Theory on the Decline and Death of International Organisations' (NestIOr) under Horizon 2020.

assistant: **Objectives**

Many international organisations (IOs) are under significant pressure. The World Health Organization was heavily criticized over its handling of the Ebola outbreak. The United States has not contributed to the UNESCO budget since 2011 and plans to quit in 2018. The United Kingdom is negotiating its exit from the EU and Burundi left the International Criminal Court. The ultimate way for states to show their discontent is to disband IOs: no less than a third of the IOs, created between 1905 and 2005, has formally ceased to exist. While academics have analysed how IOs are designed and develop, we know virtually nothing about decline and death. This project addresses therefore the question why do IOs decline or die?The key innovation is to complete the theory on the 'life and death of IOs'. The main hypothesis is that some IOs, due to their specific institutional characteristics, are better at longevity than other IOs. Flexible IOs are more likely to live longer, because they can adjust and be more responsive to external pressures, such as wars, reduced trade volumes or political turnover in the member states. Larger IOs are also more likely to live longer, as it will be more difficult for states to replace them with other IOs. They may also be in a better position to fight off external pressures, including from the membership.This project uses a mixed methods approach. Through an innovative survival analysis, it analyses the effect of institutional characteristics on the likelihood that IOs decline or die as a result of external pressures. This requires the compilation of a new dataset. The quantitative analysis is complemented with fine-grained case studies of IOs at risk of declining and dying across different policy areas. These case studies are informed by unique data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Network of National Schizophrenia Networks Studying Gene-Environment Interactions' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of EU-GEI is to identify the interactive genetic, clinical and environmental determinants involved in the development, severity and outcome of schizophrenia (EU-GEI, Schiz. Res. 2008; 102: 21-6). In order to identify these interactive determinants, EU-GEI will employ family-based, multidisciplinary research paradigms, which allow for the efficient assessment of gene-environment interactions. In order to go beyond old findings from historical convenience cohorts with crude measures of environmental factors and clinical outcomes, the focus in EU-GEI will be on recruitment of new, family-based clinical samples with state-of-the-art assessments of environmental, clinical and genetic determinants as well as their underlying neural and behavioural mechanisms. New statistical tools will be developed to combine the latest multilevel epidemiological with the latest genome-wide genetic approaches to analysis. Translation of results to clinical practice will be facilitated by additional experimental research and risk assessment bioinformatics approaches. This will result in the identification of modifiable biological and cognitive mechanisms underlying gene-environment interactions and the construction of Risk Assessment Charts and Momentary Assessment Technology tools which can be used for (i) early prediction of transition to psychotic disorder in help-seeking individuals with an at-risk mental state and (ii) early prediction of course and outcome after illness onset. In order to reach these goals, EU-GEI has assembled a multidisciplinary team of top schizophrenia researchers who have the range of skills required to deliver a program of research that meets all the call’s requirements and who have access to / will collect a number of unique European samples. The partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of microtubule plus-end tracking proteins in synaptogenesis' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Plus-end tracking proteins, or +TIPs, are microtubule (MT) binding proteins that specifically associate with the distal ends of MTs. +TIPs are both involved in the regulation of MT dynamics and intracellular membrane transport over MTs. Since +TIPs are import ant mediators of MT dynamics during axonal growth, we speculate that they might also have a role in the establishment of synaptic contacts. This will be addressed by using +TIP knockout mice as model systems for abnormal synaptic formation and/or stabilization. Our studies will be performed in primary hippocampal neuronal cultures from these mice and will be supported by siRNA experiments.The finding of abnormal synaptic contacts in +TIP deficient cells might be due to a deregulation of MT dynamics and/or to altered transport of synaptic proteins. Both questions will be addressed by using immuno-fluorescence time-lapse microscopy and by the use of a new microscope that allows the analysis of vesicle movement in living cells. Finally, we will study how distinct signal ling pathways involving the kinases GSK-3 and Abl lead to +TIP-mediated local rearrangements of MTs.Biochemical studies will be performed in neuroblastoma and non-neuronal cell lines. The role of these signalling pathways during synaptogenesis will be evaluated in cultures of mossy fibres stimulated with Wnt7a. We expect that the results obtained from this project will help to improve our understanding of +TIP function during the highly complex process of synapse formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Thematic network on the role of monitoring in a phased approach to disposal' (1998-2002).

assistant: **Concept**

The scope of work will cover potential monitoring requirements during all stages of disposal system development.It will consider a broad range of potential monitoring requirements including, but not limited to, monitoring for the following reasons:(i) Establishment of baseline conditions.(ii) System of performance at the time of monitoring.(iii) Provision of data to be used in evaluations/assessments of repository performance.(iv) Monitoring in the broad sense e.g. developments in relevant areas of science.It is proposed that the project is divided into four work packages..The first work package would be information gathering and improving the definition of work to be carried out in subsequent work packages..The second work package would be to describe what parameters might require monitoring and the reasons for that monitoring..The third work package would address techniques and strategies for monitoring..The fourth work package would be to compile a final report of the project.Many countries are now considering a phased approach to disposal of radioactive waste, whereby disposal would be implemented by a series of reversible steps. At each stage in the process, information from monitoring will be required as inputs to the decision-making process. A recent EC Concerted Action on Retrievability concluded that in most EC countries monitoring programmes are in an early stage of development.This thematic network will bring together expertise from many countries in order to achieve the following objectives:- To improve the understanding of the role of and options for monitoring within a phased approach to disposal.- To identify how monitoring can contribute to decision-making, operational and post-closure safety and confidence in safety.A project inception report describing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DNA replication at the heart of cell fate decisions and cancer development' (RepliFate) under Horizon Europe.

assistant: **Objectives**

RepliFate is doctoral network designed to train the next generation of European researchers in the field of DNA replication, cell fate and cancer. We have designed an innovative training program that aims at providing interdisciplinary and intersectoral formation for the fellows. We base the network in inclusion, creativity and communication as the base to train the researchers in all aspects of scientific activity. RepliFate will investigate the mechanisms through which changes in DNA replication influence cell identity, respond to different kinds of stress, and prevent malignant transformation. We will put DNA replication at the center stage as the driver of these processes and not a mere bystander, using recent technological to better understand the role of DNA replication as a determinant of cell fate and cancer. RepliFate links academia with industry and society and will provide new opportunities for innovation in one of the main societal challenges in human health, cancer. The scientific roots of RepliFate are set on the Horizon Europe Mission Cancer objectives Understand and Optimise. We will pave the way for the development of innovative cancer treatments exploring the links between DNA replication and cell fate, the immune response and unscheduled cell proliferation.RepliFate is composed by 10 European beneficiaries (9 from academia and 1 from industry) along with 2 Swiss associated partners (with their own funding from the Swiss government), 4 companies, 1 news agency and 2 non-profit organizations as associated partners from 8 different countries. Putting the focus on the fellows, we have combined our expertise to create an outstanding training program with the objective to generate leaders in the field with independent and out-of-the-box views to drive the k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of genes (outside PRNP) modulating scrapie susceptibility' (IGMSS) under Sixth Framework.

assistant: **Objectives**

To identify new genes modulating prion resistance, we took advantage of the sheep model, where susceptibility/resistance is mainly dominated by specific allelic forms at the prion (PRNP) locus. For this purpose, two families were scanned with microsatellite markers for genes modulating scrapie resistance. The ARQ/VRQ individuals were raised in an environment where scrapie is naturally present. When the lambs reached the age of 3 and 6 months amygdales biopsies were made in order to evaluate the presence of prions, and these phenotypical data was recorded. Subsequently, the animals were observed until the appearance of the first clinical signs of the disease and, the diagnosis was systematically confirmed by an histological examination of the brain.In parallel with the progress in the genetical refining of the QTL region, we develop a research program aiming at gene expression pattern alterations caused by scrapie in organs relevant for the disease. For this, mRNA is extracted from cerebral tissue and lymphoid tissue of sheeps of same breed, age and sex, healthy or ill. Organ-specific cDNA pools are synthesized and a differential expressed library of ~2000 clones will be constructed by Suppressive Subtractive Hybridisation (SSH). The cDNA products will be spotted on high-density nylon macroarrays, hybridise with cDNA from animals of various genotypes and disease state, before and after the apparition of symptoms. In parallel, the differentially expressed genes identified, will be mapped on the sheep genome to evaluate their position in reference to QTL regions.This double approach (genetic mapping and functional genomics) could therefore speed up the identification of genes involved in scrapie action modulation. Furthermore, analysing the function of these genes could op