RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synergistic Catalysis with Advanced Metal-Organic Structures for Sustainable Biomass Conversion', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Our continued energy reliance on the depleting, and with a large climate footprint, fossil fuel reserves, as well as the increasing instability of the global supply chain network, threaten our energy security, one of the pillars of life-quality, societal, and economic growth. In 2016, 195 countries committed to the Paris Agreement to move towards climate-resilient development with lower greenhouse gas emissions for sustainable growth. The SYMBIOS project offers an innovative green solution by efficiently converting waste biomass into biofuels, promoting our transition toward renewable energy, circular carbon economy, energy security, and reduced environmental footprint. SYMBIOS proposes a ‘symbiotic’ approach between nanoparticulate catalysts and the catalytically active metal nodes of metal-organic frameworks (MOFs), to engineer synergistic and high-efficiency active sites for converting low-energy-density biomass-derived alcohols into higher-energy-density biofuels. Moreover, MOFs crystallization will rely on the synthesis of tailored and functional organometallic building blocks which will stabilize the entrapped nanocatalysts, for their seamless integration. The new catalysts will leverage the unique properties of MOFs to lower energy input reaction requirements and maximize yield, selectivity, and recyclability. SYMBIOS aims to contribute towards the EU’s climate commitments by opening a new avenue for sustainable waste reforming and reducing the reliance on fossil fuels.


**Keywords:** Single-Atom Catalysis,  Waste Reforming,  Biofuels,  Metal-Organic Frameworks,  Organometallics,  Nanoparticles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of human DNA replication' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Eukaryotic DNA replication is mediated by a complex machinery consisting of several dozen proteins that ensures precise duplication of chromosomes in S phase of the cell cycle. The Diffley laboratory recently reconstituted the core Saccharomyces cerevisiae replication machinery in vitro from 19 replication factors containing about 50 individual protein subunits. This system allowed to study mechanisms of yeast MCM loading onto DNA and of yeast CMG replicative helicase activation. In human cells however, the process of replication initiation and its regulation are less well understood. In particular, the firing factors that activate the CMG helicase differ in domain composition and phospho-regulation from the yeast orthologs. Mechanistic studies are required to understand how human DNA replication is initiated and regulated at the molecular level. I will first reconstitute human DNA replication in vitro from completely recombinant components using methodology that I developed during my PhD. I will then use this system to study how the human replicative helicase is activated on the molecular level and how activation is regulated by phosphorylation using biochemistry. I will use cryo-electron microscopy (cryo-EM) to study the architecture of complexes involved in replication initiation. The reconstituted human system could in future enable studies on disease mechanisms and could allow screening for antiproliferative small molecule inhibitors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Signal processing for improved qualification for non-destructive testing of ageing reactors', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Ultrasonic inspection plays an important role in assuring the integrity of stainless steel components in nuclear power plant. However there are currently significant limitations in inspection capability. This project covers work aimed at achieving a step-change in inspection capability by developing and exploiting new signal processing methods. Ultrasonic data will be generated from deliberately defective austenitic stainless steel test samples simulating nuclear plant components. This data will then be used to develop optimised signal processing methods, which will improve the ability to detect and size cracks. The signal processing methods will be incorporated into software and evaluated by practical ultrasonic inspection trials to demonstrate the extent to which the target improvements have been achieved. An ultrasonic model will also be produced to help develop and test the signal processing methods, plus interpret the results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Risk assessment Tools for severe side Effects after breasT Radiotherapy:  radiation safety through biological extended models and dIgital twinS' (TETRIS) targeting Horizon Europe.

assistant: **Abstract**

Radiation protection and safety measures are essential to ensure adequate quality & safety in radiotherapy (RT). Side effects are systematically mitigated through optimisation and individualisation.Breast cancer (Bca) is the most common cancer in women in Europe, leading to millions of BCa survivors in Europe; this group is projected to increase in the next decades. Randomised trials established the role of RT following breast surgery. Careful RT planning and delivery allow targeting the breast while minimising the dose to organs at risk. Yet, some doses unavoidably reach the lung and the heart, putting BCa patients at risk for severe cardiac and pulmonary disease and second cancers. Quantitative personalised risk scores for late severe cardiac/pulmonary disease/second cancers following RT would reveal opportunities to further mitigate the risk of side effects at the individual patient level. Risk scores would provide a quantitative guide when shaping the patients’ follow-up and screening program to assess the risk or presence of subclinical diseases.Within TETRIS, we propose to design and test quantitative personalised low-level risk scores based on dose-response relationships already published in the literature and refined risk scores which merge patient-specific features (from imaging, genetics and transcriptomics) with RT dose.The project also proposes to explore the opportunities and challenges of applying digital twins (DTs) in RT safety. We will use the historical cohort to develop the prototypes and evaluate the gain we can have using digital twins for risk assessment instead of model-based risk scores. Using a prospective collection of detailed patient data, we will demonstrate the possibility of refining DTs, allowing a deeper description of the single patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Giving Land Back: Property, Authority and Agrarian Change in Myanmar'.

assistant: **Objectives**

In the wake of violence, dispossession, and regime change, giving back land offers a critical opportunity to address historic injustice. Yet seeking to reconcile the past invites conflicts over material distribution and political inclusion in the nation’s future. This project investigates land restitution in Myanmar, a formerly authoritarian, predominantly agrarian nation currently undergoing a rapid, public and bumpy transition towards democracy. Building on over five years of research on land reform and agrarian change in Myanmar, I ask how the new government’s efforts to return land are taking shape, and what these processes mean for the nation’s future and for the place of rural land in global development. Under the guidance of Prof. Christian Lund, a leading scholar on the production of property and citizenship in developing societies, this project will contribute new empirical analysis, conceptual insights, and policy recommendations to inform urgent debates on rural transformation, democratization and social inequality.


**Keywords:** land, property, citizenship, rural transformation, agriculture, development, political systems and institutions, governance, state formation, conflict and conflict resolution, Myanmar, ethnography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modular Open Platform for Static Analysis'.

assistant: **Innovation**

The Mopsa project aims at creating methods and tools to make computer software more reliable.Programming errors are pervasive with results ranging from user frustration to huge economical or human losses. Traditional test-based methods are insufficient to eliminate all errors. The project will develop static analyses able to detect at compile-time whole classes of program defects, leveraging the theory of abstract interpretation to design analyses that are approximate (to scale up to large programs) and sound (no defect is missed). Static analysis has enjoyed recent successes: Astrée, an industrial analyzer I have coauthored, was able to prove the absence of run-time error in Airbus software. But such results are limited to the specific, well-controlled context of critical embedded systems. I wish to bring static analysis to the next level: target larger, more complex and heterogeneous software, and make it usable by engineers to improve general-purpose software.We focus on analyzing open-source software which are readily available, complex, widespread, and important from an economical standpoint (they are used in many infrastructures and companies) but also societal and educational ones (promoting the development of verified software for and by citizens). A major target we consider is the set of technologies at the core on Internet on which static analysis could be applied to ensure a safer Internet. The scientific challenges we must overcome include designing scalable analyses producing relevant information, supporting novel popular languages (such as Python), analyzing properties more adapted to the continuous development of software common in open-source. At the core of the project is the construction of an open-source static analysis platform. It will serve not onl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'INNOVATIVE POLYMER-BASED COMPOSITE SYSTEMS FOR HIGH-EFFICIENT ENERGY SCAVENGING AND STORAGE'.

assistant: **Concept**

InComEss seeks at developing efficient smart materials with energy harvesting and storage capabilities combining advanced polymer based-composite materials into a novel single/multi-source concept to harvest electrical energy from mechanical energy and/or waste heat ambient sources. Three Energy Harvesting Systems (EHSs) configurations will be realized through the combination of high performance piezoelectric (PE), thermoelectric (TE) and Thermo-Piezoelectric (TPE) generators and monolithic supercapacitors (SCs) to power selected wireless sensors nodes to be implemented in different IoT scenarios for Structural Health Monitoring (SHM) in buildings and aircrafts (using a new miniature wireless Fiber Optics Sensing (FOS) interrogator) and accurate location and monitoring of vehicles through GPS and MEMS sensing. Advanced concepts for efficient energy transfer will be implemented for increased energy conversion efficiency of the overall EHSs.InComEss EHSs will involve  the following smart materials developments: 1) advanced lead-free PE composite-based mono-/bi-component fibres with enhanced PE characteristics up to 100ºC/250ºC for their application into single/hybrid PE/TPE generators; 2) innovative high-performance thermoplastic-based p-and n-type TE composites with enhanced Seebeck coefficients in the range from –25ºC up to 250ºC for their application in single/hybrid PE/TPE generators; and 3) printable high energy density PANI/carbon-based composite electrode materials with enhanced specific capacitance and stability for their incorporation into the monolithic supercapacitor (SC) to store the energy harvested.InComEss technologies, applications and services will impact the partners turnover by €100M after market up-take, generating more than 70 jobs and leveraging the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'An avant-garde measuring principle based on the potentiometric method using signals from the kidney to monitor hospitalised patients water-volemic state'.

assistant: **Concept**

The need of high quality and cost-efficient hemodynamic and metabolic state monitoring devices is increasing exponentially, due to e.g. ageing population, chronic health conditions, health support system advance in developing courtiers and rural areas and the growing number of cases of chronic conditions in Europe and worldwide. Existing monitoring technologies are either very basic (e.g. ECG and heart rate), energy consuming or are difficult in use and installation among many other drawbacks.  Several research studies suggest using alternative urinary ammonium measurements (e.g. 24-hours analysis). But urine anion and osmolar gaps connected to this type of analysis are not accurate enough to be reliable surrogate measures, since this method requires sample treatment.KARDIA a company founded in 1995 in Milan, developed a monitoring device that doesn’t require sample treatment, is non-invasive, low cost, low energy consuming and it is easy to use, install, move, handle: K.IN.G.- Kidney INstantaneous monitorinG.  K.IN.G. aims to reduce morbidity and mortality rates among patients and to optimize therapeutic strategies by providing a cost-effective innovative and non-invasive monitoring solution. The solution also simplifies work of medical staff as it is portable and easy to use. K.IN.G. offers strong environmental advantages, as it diminish the energy consumption by 50%. It. also has the potential to boost the growth of KARDIA, reaching unprecedented sales parameters leading to the creation of new jobs and to contribute to KARIDA’s mission to ensure gender balance by recruiting female staff.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EmotAI: Emotion Driver State Monitoring System based on AI' (EmotAI) under Horizon Europe.

assistant: **Objectives**

According to the European Union (EU) statistics, in Europe alone road crashes kills around 500 persons every week, more than 25000 people die every year, and more than 135000 are seriously injured, with a monetary cost of around 280 billion EUR. To halt this uncovered pandemic, the EU has declared its ambitious long-term goal call ‘Vision Zero’ to reduce the number of casualties and accidents to zero by the year 2050. To advance towards this goal, a General Safety Regulation (GSR), has been recently mandated to install driver assisting devices by 2030 focusing on the major factors causing crashes: driver distraction, fatigue and drowsiness. To comply with these regulations automobile companies are eager to install advanced driver assistance technologies in vehicles for driver assistance and alerting. Current solutions however are limited to some specific aspects (e.g., sleeping, phoning, looking off,), without having a holistic understanding of the whole situation of the driver, and with a big rate of false alarms that generate more distraction and annoyance to the driver, that ultimately prefers to switch it off to avoid having continuous false alarms without any benefit. To tackle this important challenge, in this fellowship, we propose to develop EmotAI (Emotion Driver State Monitoring System based on AI) a non-invasive tool that aims to address driver state monitoring and alertness challenges, to maximize driver attention and safety. We will be doing this by integrating novel AI-based technology using deep neural networks with non-invasive sensors and cameras with the novel theories in cognitive psychology in driving that aim to combine the information from 4 main pillars: the attention level, the activation level, the performance level, and the external factors. Ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Environmental and genetic factors in bladder cancer: a multicentric case-control enquiry in Europe' (1994-1998).

assistant: **Innovation**

Brief description: The only specific occupational exposures that have been unequivocally associated with excess bladder cancer risk are aromatic amines. Classical epidemiological approaches have not been able to identify other specific exposures accounting for the excess risks observed in many occupations. Evidence is controversial concerning environmental exposures such as water chlorination or environmental tobacco smoke. The role of many genetic polymorphisms for the occurrence of bladder cancer has not been well investigated, both concerning their modulating role on the effect of specific risk factors and also their role on the formation of aromatic amine - DNA adducts. In the last years, many studies have examined genetic alterations in bladder cancer such as mutations in the P53 gene. Their association with tobacco smoke, occupational exposure to aromatic amines and specific genetic polymorphisms is not well established.A multicentric hospital based case-control study will be carried out in five EU countries (Denmark, France, Italy, Portugal and Spain) following parallel methods. Approximately 1,500 male and female incident bladder cancer cases and 1,500 noncancer hospital controls will be enrolled in the study during a period of two years. Subjects will be personally interviewed using a computer assisted structured questionnaire on sociodemographic characteristics, tobacco, occupation, environmental exposures, medical history, diet and other potential risk factors. Detailed supplementary information will be requested for specific occupations and industries. Blood, urine, normal urothelium and. fresh tumour samples and/or paraffin blocks (cases only) will be collected from the subjects. Specific centralised laboratory analyses will be carried out in Milan (aromati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of Nitroxyl (HNO) in the cardio and cerebrovascular system' (HNO).

assistant: **Concept**

The World Health Organization reported that in 2003 cardio and cerebrovascular diseases such as heart failure, myocardial infarction, hypertension, coronary artery disease and stroke make up to 16.7 million (29%) of total worldwide deaths (www.who.int). In Europe these diseases are responsible for 27% to 56% of total deaths and are estimated to require 53% of the total health expenditures. Despite extensive efforts to develop therapeutic strategies for these diseases the results are not yet satisfying and there is a need for further development of new pharmacological treatments. The function of nitric oxide (NO), which is produced in the healthy endothelium, has been summarized as “anti-atherosclerotic”. Therefore, endothelial dysfunction, i.e. the inability of the endothelium to produce NO and subsequent impaired vasorelaxation leads to pathophysiological conditions, such as atherosclerosis, which is one of the major pathogenic factors contributing to the cardio and cerebrovascular clinical endpoints mentioned above. Under certain conditions, nitric oxide synthase has been shown to generate nitrogen species that are chemically distinct from NO. Among these, nitroxyl (HNO), the one-electron-reduced form of NO, has attracted scientific interest for its unique cardio and cerebrovascular effects that are pharmacologically different from NO. These effects make HNO a very promising pharmacological agent to be used in the treatment of cardio and cerebrovascular diseases. Furthermore, we recently found that HNO can be formed from myoloperoxidase (MPO) in vitro. MPO is upregulated under inflammatory conditions and inflammation is one major pathophysiological mechanism in cardio and cerebrovascular diseases.  Thus, the basis to promote HNO as a therapeutic strategy is the unders