RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Survey of the University Career of Female Scientists at Life Sciences versus Technical Universities', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The aim of the project is to carry out an innovative pilot survey to enhance existing knowledge on career patterns of female scientists at universities. The project will open up new perspectives for further in-depth work in the field by mapping the situation of female researchers in engineering and life sciences in seven universities in six countries in Europe with special regard to gender differences in research careers, critical areas where women are underrepresented, leading university positions, access to funding, mobility and work-life balance. Women face great difficulties in developing professional careers in equal opportunities to those of men in these sectors, especially regarding their proportion and representation at the higher levels of the hierarchical ladder.The project will examine and compare the situation of female researchers and decision makers. A methodology to map careers in university will be designed and tested in the partner institutions. The survey will involve PhD students, researchers and decision makers as well. Besides the collection of detailed statistics - which is missing at almost all involved universities - the consortium will conduct interviews with those female researchers who succeeded in doing a career in these areas of science in spite of the difficulties. The project will map not only the good practices but the bad ones as well in order to determine how the career of female researchers is set back in these areas.Furthermore it is one of the objectives of the project to draw the attention of the university managements to the importance of ensuring equal opportunities to women and men and the practice of gender mainstreaming as a policy of the European Union. The partner countries include two new member states (Hungary and Estonia),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intra-patient evolution of HIV', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

HIV is one of the most rapidly evolving organisms known. Understanding its evolutionary dynamics is essential for successful drug treatment or vaccine design.  At the same time, this rapid evolution makes HIV an ideal model system to study fundamental problems in evolutionary dynamics: In HIV, one can directly observe evolution over genetic distances that correspond to millions of years of evolution in other organisms.This proposal combines time series of ultra-deep sequence data of HIV from individual patients, functional information on drug resistance, and methods from statistical physics to study evolution. The sequence data will observe the dynamics of the genotype distribution in the population, while the exceptionally well characterized biology of HIV will allow the assignment of functional significance to the observed genotypic changes. These two levels of description will be integrated by theoretical models that describe how selection on phenotypes feeds back on the genotype distribution.Specifically, we will determine the fundamental parameters of HIV evolution such as selection strength, recombination rates, and the patterns of genetic interactions from the time resolved data obtained by deep sequencing. We will use the data base of viral sequences that evolved in response to drug treatment to infer the fitness landscapes of drug resistance. These two projects will be integrated in a quantitative model of drug resistance evolution. In a third project, we will quantify how genetic interactions affect the formation of circulant recombinant forms of HIV.Using HIV as a model system, we will develop and test theories of multi-locus evolution, characterize fitness landscapes and genetic interactions, and quantify the impact of recombination on HIV evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neural mechanisms of fear and anxiety: Interactions between proteases and extra-cellular Milieu' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Understanding neural bases of stress, fear and anxiety is of an immense importance to modern society. Anxiety disorders affect about 25% of adults at least once in their lives, and make a huge social, family and welfare impact. The most dramatic form, post- traumatic stress disorder (PTSD) is characterized by cognitive impairment, depression, fear, anxiety and may eventually lead to suicide. Understanding of the neural mechanisms of PTSD and other anxiety disorders could reduce the personal and societal impact through development of more efficient therapies.Fear memories are encoded as changes in strength of synaptic connections, a process called plasticity. Extra-cellular proteolysis provides an attractive mechanism underlying neuronal plasticity. Precisely orchestrated exocytosis of a protease could help remodel synaptic connections by degrading extra-cellular matrix proteins, interacting with membrane receptors or activating latent growth factors. Consistent with this idea we have recently shown that the tissue plasminogen activator (tPA)/plasmin system is regulated by restraint stress in the hippocampus and amygdala, and it promotes stress-related neuronal remodelling.Moreover, our data indicate that other serine proteases are also key players in stress-induced plasticity and anxiety. The molecular mechanisms by which proteases facilitate stress-induced anxiety remain unclear. We propose to identify protease-regulated genes in the amygdala, and examine their roles during psychological stress using a combination of genetic, cell biological, pharmacological, electrophysiological and behavioural approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gravitational Lensing as a Cosmological Probe' (GLENCO), addressing dissemination and exploitation.

assistant: **Impact**

I propose to develop new observational probes of cosmology basedon gravitational lensing.  The project consists of three themes:1) Computer tools will be developed for detecting and measuring small-scale structures inthe distribution of dark matter using strong gravitational lenses.  This will resolve one of thefew persistent conflicts between observations and the predictions of the Cold Dark Matter(CDM) model.  The tools will enable the scientific community to take full advantage of presentimaging data and future data coming from missions like the proposed EUCLID satellite.2) There are several proposed and ongoing surveys designed to measure the weakgravitational lensing of galaxies across large regions of the sky and to measure the redshiftsof hundreds of millions of galaxies.  To maximize the use of this data I propose a joint analysisof redshift and lensing surveys that will increase the sensitivity to the expansion history of the Universe and separate two observational consequences of dark energy which are otherwise degenerate in weak lensing data alone. This would enable us to verify whether generalrelativity is valid on cosmological scales.3) The feasibility of studying cosmology using future radio observations of the 21 cm radiation coming from early epochs of the Universe will be investigated.  My work has shown that thegravitational lensing of this radiation could provide powerful constraints on the density of the Universe, dark energy's equation of state, and the masses of neutrinos. It should also bepossible to actually map the distribution of dark matter across large sections of sky with highfidelity.  My goal is to treat the observational noise and systematics realistically and determinewhat impact telescope design and survey strategy have on the scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'STABLE ISOTOPES OF METALS AS POLLUTANT TRACERS IN THE ATMOSPHERIC ENVIRONMENT' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The release of metals into the environment from anthropogenic activities entails major risks to ecosystems and human health. The inhalation of airborne particle matter with diameters of 10 μm or less leads to pulmonary disease and lung damage. Moreover, zinc particles are inferred to play an important role in heterogeneous processing of NOx species. Therefore, sources and fate of metals need to be fully understood so that abatement policies can be developed and emissions are maintained at sustainable levels.The differences in the relative mass-dependent abundances of stable isotopes allow the determination of the sources of metals and thus have the unique potential to tackle this problem. Significant isotopic variability of priority pollutant metals such as Zn, Cu and Cd has been observed in urban environments, suggesting that the metal stable isotopes can be successfully used for source tracing, similar to the very successful approach with Pb.ISOTRACE addresses the potential of the stable isotope technique as a novel technique to trace metal pollutants in particulate matter of the urban environment in a systematic and comprehensive way. This will be achieved by the first experimentally determining of the isotope fractionation of Zn, Cu, Cd and Fe during various industrial processes using well-controlled laboratory tests. Also, new laser ablation techniques will be used to map isotope fractionations in situ in aerosol samples for precise and accurate isotope ratio measurements. This will be followed by a thorough study assessing the isotope variations in sources and sinks of urban atmospheric particulate using a large measuring campaign in London urban environment which will provide potential additional information on transboundary pollution and allow the development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of Class IIa Histone deacetylases in hematopoietic cell differentiation' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Chromatin, the higher order structure of DNA and protein, forms a barrier for gene transcription. Modification of histones, a major component of the chromatin, is a critical mechanism by which the barrier is regulated.  An important modification, which is thought to activate transcription, is the acetylation of histones.  Regulation of histones acetylation is performed by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). Mammalian HDACs are divided into three distinct classes based on their homology to yeast proteins.  Class I HDACs (HDAC1, 2, 3 and 8), Class II HDACs, which are subdivided into two families, Class IIa (HDAC4, 5, 7 and 9) and Class IIb (HDAC6 and 10) and Class III HDACs, also named sirtuins, which comprises Sirt1, 2, 3, 4, 5, 6 and 7.  In contrast to other HDACs, Class IIa HDACs are expressed in a tissue specific manner and have been shown to play an important role in cell differentiation.  The hematopoietic system is a complex and interesting model of cell commitment and differentiation. Hematopoietic lineages are specified by lineage-restricted transcription factors that result in a distinct gene expression pattern.  However, little is known about the role of chromatin modifying enzymes in the hematopoietic system. It has been shown that HDAC5 and HDAC9 are expressed in hematopoietic cells.  However, their role in commitment of hematopoietic cells has never been investigated.  Here, I propose to study the role of HDAC5 and HDAC9 in lineage commitment of hematopoietic cells.  By using a genomic approach, as well as, knock out and trangenic mouse models, I will elucidate the lineage compartment where they are expressed, the specific target genes repressed by both proteins and their role in hematopoietic ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Virus Inhibition by siRNA Optimized by NMR' (VISION).

assistant: **Innovation**

The last two years, profoundly marked by the COVID-19 sanitary crisis, have demonstrated the difficulties to answer adequately to the emergence of novel pathogenic viruses. Today, no broad-spectrum antiviral exists similar to antibiotics targeting bacteria. Repositioning of existing molecules had limited success despite intense initial hopes. Vaccines have played a major role in fighting the pandemic and limiting the impact of the virus, however it remains insufficient to end the pandemic, due to many factors including their worldwide uneven accessibility, their intrinsic efficiency towards different variants and the complex socio-political context related to mass vaccination. There is therefore an urgent need of novel approaches to design molecules targeting viruses and in particular SARS-CoV-2. To answer this challenge, we propose a novel strategy derived from fundamental research on small interfering RNA (siRNA). This project derives from the ERC Starting Grant PARAMIR, in which novel structural biology approaches are proposed to understand the mechanism of recognition of a similar class of RNA involved in numerous diseases, especially cancer. Our approach combines the latest advances in SARS-CoV-2 virology and structural biology to propose efficient and specific molecules active towards a broad range of SARS-CoV-2 current and future variants. If successful the project will lead to a class of siRNA, with optimized specificity and stability, validated in vitro and ex-vivo in a reconstituted human airway epithelial model, and ready for testing towards pre-clinical and clinical stage. Finally, the strategy proposed here will be on a longer term applicable to multiple other pathogenic viruses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An integrated methodology for projecting the impact of climate change and human activity on soil erosion and ecosystem degradation in the Mediterranean: A climatological gradient and dynamic systems approach.' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

To develop and test an integrated complex systems methodology for projecting the impact of climate change and human activity on soil erosion and ecosystem degradation along climatological transects located on representative geo-ecological zones on limestone and marl areas at sites across the Mediterranean.Key process of erosion and desertification will be measured and monitored at different scales along climatologically documented transects in Alicante, Crete, Israel. These measurements will be related to grazing, fire, land use and economic activity, as these vary with respect to climate. Attention will be given to establishing how relationships between processes at different hierarchical scales are affected by the above mentioned stressors. In Israel and Alicante soil erosion will be measured to provide reference information for monitoring and modelling and. In Crete, vegetation responses to stressors will be documented and modelled. At the Alicante site the data collection and modelling will interface with a socio-economic study at the same location carried out under the ARCHIOMEDES project. The soil and hydrological modelling will be interfaced with the MODMED project modelling. Response unit methodology, dynamic systems modelling and remote sensing will be applied to scale up process-pattern features and for integrating the effects of climatologically, socioeconomically and biophysically driven processes. Dynamic models will further be used for scenario analysis to make projections about the future risks resulting from climate change, drought, fire and human activity in Mediterranean limestone and marl areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Combining sensitive biomarkers for early diagnosis of AD: A multi-modal approach' in the context of a Seventh Framework call.

assistant: **Objectives**

Alzheimer’s disease (AD) is currently the leading cause of dementia, being expected to double in the coming decades. Increasing evidence suggests the pathological mechanisms of AD become active several years before neurons start dying and dementia manifests. During this prodromal stage, referred to as Mild Cognitive Impairment (MCI), effective treatments would have the greatest impact because cognitive function is still relatively preserved. Hence, it is crucial to identify these subjects at increased risk of developing AD at the earliest possible stage. Several neuroimaging, cerebrospinal fluid and neuropsychological biomarkers for early detection of AD have been proposed. However, none of these biomarkers has been established as an ideal diagnostic or prognostic indicator. Considering the complexity of the AD process and the multiple dynamic pathological changes that occur during the course of the disease it is rather unlikely that a single ideal biomarker even exists. Hence a combination of both already established and new sensitive biomarkers has the potential of significantly improving the accuracy of diagnosis compared to each of them alone. In the current project we will combine several multimodal biomarkers from neuroimaging, cerebrospinal fluid, genetics and cognitive tests in multivariate analyses in order to determine which marker or combination of markers is optimal for early diagnosis of AD. We will create a discriminant pattern of disease for the diagnosis of AD, prediction of conversion of MCI to AD and discrimination of MCI due to AD pathology and MCI associated with Parkinson’s disease. These patterns will be based on information from well-established measures that have shown value as AD biomarkers, in addition to new measures suggested as potentially n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INDUSTRIALISATION OF A DISRUPTIVE ACTIVE FIRE-FIGHTING SYSTEM' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

JET ANTI-FIRE has the objective to bring to market the most secure active fire-fighting system in the market, which is able to extinguish a fire in 50% less time while saving 75% of O&M costs and 55% of water compared to existing systems, thus guaranteeing more security for the operator and patrimony while fulfilling the local regulation far better than current systems. The innovation is based on two new devices: a hydrant tap that maintains the pressure balanced in a building including skyscrapers, and a jet system that breaks water producing an efficient water fog and so temperature decrease 50% faster than with traditional methods, allowing fire-fighters get closer to the fire focus in secure conditions. FIRING is an Italian based company, they are experts in active fire-fighting systems and solutions with more than 12 years of experience. FIRING experience in active fire-fighting systems shows us, that existing methods have problems to comply with regulation especially in high buildings. This makes expensive O&M methods as hydraulic compensation engineering and dynamic tests every six months necessary. Because of that fire-fighting experts are demanding more efficient and cost effective fire-fighting systems. Our system implies to invest a 20% more in active fire-fighting systems but the gain in higher security, lower maintenance and lower water usage outperforms this slightly higher initial investment within the first year of usage. FIRING wants to participate with JET ANTI-FIRE in the extension and homogenization of secure and effective fire-fighting systems in Europe.


**Keywords:** FIRE-FIGHTING, FIRE, SPRINKLER, SECURITY, WATER, HYDRANT TAP, ANTI-FIRE, FIREMEN, WATER EFFICIENCY,  PRESSURE BALANCE