RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Arctic Sea Ice and Greenland Ice Sheet Sensitivity'.

assistant: **Objectives**

The cryosphere is in fast transition. The possibility that the ongoing rapid demise of Arctic sea ice may instigate abrupt changes on the Greenland Ice Sheet (GIS) is not tackled by current research. Ice cores from the GIS show clear evidence of past abrupt warm events,up to 15 degrees warming in less than a decade, possibly caused by disappearing se ice in the Nordic Seas..Arctic sea ice extent was in 2012 half of the 1979-2000 average. Satellite data document an increasing loss of GIS ice mass since 1990 and temperatures have risen markedly at the GIS summit. Strong transient changes in both Arctic cryospheric entities prompts the question: Is the dramatic decline in Arctic Sea Ice heralding a new phase of abrupt change, similar to those recorded in ocean sediments and ice cores?  Such changes would have major consequences for the GIS mass balance and global climate and sea level. Ice2Ice will approach this complex problem by integrating 4 PI teams from three Nordic world class research centres comprising empiricists and dynamicists specialized in Arctic and Greenland  atmospheric, oceanic and cryospheric sciences. With an innovative combination of synchronized records of GIS parameters, records of sea ice change and models ranging from global climate models to regional and process models, Ice2Ice will be the first concerted effort to tackle the question of the cause and future implications of past abrupt climate change in Greenland, the main hypothesis being that Arctic and sub-Arctic sea ice cover is key to understand past and future Greenland temperature and ice sheet variations. In Ice2Ice this will be done by:a)describing the nature, timing and extent of abrupt events across climate archives,b)resolving mechanisms behind the sudden demise of sea ice cover,c)ident
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wiring synaptic circuits with astroglial connexins: mechanisms, dynamics and impact for critical period plasticity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Brain information processing is commonly thought to be a neuronal performance. However recent data point to a key role of astrocytes in brain development, activity and pathology. Indeed astrocytes are now viewed as crucial elements of the brain circuitry that control synapse formation, maturation, activity and elimination. How do astrocytes exert such control is matter of intense research, as they are now known to participate in critical developmental periods as well as in psychiatric disorders involving synapse alterations. Thus unraveling how astrocytes control synaptic circuit formation and maturation is crucial, not only for our understanding of brain development, but also for identifying novel therapeutic targets.We recently found that connexin 30 (Cx30), an astroglial gap junction subunit expressed postnatally, tunes synaptic activity via an unprecedented non-channel function setting the proximity of glial processes to synaptic clefts, essential for synaptic glutamate clearance efficacy. Our work not only reveals Cx30 as a key determinant of glial synapse coverage, but also extends the classical model of neuroglial interactions in which astrocytes are generally considered as extrasynaptic elements indirectly regulating neurotransmission. Yet the molecular mechanisms involved in such control, its dynamic regulation by activity and impact in a native developmental context are unknown. We will now address these important questions, focusing on the involvement of this novel astroglial function in wiring developing synaptic circuits.Thus using a multidisciplinary approach we will investigate:1) the molecular and cellular mechanisms underlying Cx30 regulation of synaptic function2) the activity-dependent dynamics of Cx30 function at synapses3) a role for Cx30 in wiring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coevolutionary Policy Search' (CoPS) targeting Horizon 2020.

assistant: **Abstract**

I propose to develop a new class of decision-theoretic planning methods that overcome fundamental obstacles to the efficient optimization of autonomous agents.  Creating agents that are effective in diverse settings is a key goal of artificial intelligence with enormous potential implications: robotic agents would be invaluable in homes, factories, and high-risk settings; software agents could revolutionize e-commerce, information retrieval, and traffic control.The main challenge lies in specifying an agent's policy: the behavioral strategy that determines its actions.  Since the complexity of realistic tasks makes manual policy construction hopeless, there is great demand for decision-theoretic planning methods that automatically discover good policies. Despite enormous progress, the grand challenge of efficiently discovering effective policies for complex tasks remains unmet.A fundamental obstacle is the cost of policy evaluation: estimating a policy's quality by averaging performance over multiple trials.  This cost grows quickly with increases in task complexity (making trials more expensive) or stochasticity (necessitating more trials).  To address this difficulty, I propose a new approach that simultaneously optimizes both policies and the manner in which those policies are evaluated.  The key insight is that, in many tasks, many trials are wasted because they do not elicit the controllable rare events critical for distinguishing between policies. Thus, I will develop methods that leverage coevolution to automatically discover the best events, instead of sampling them randomly.If successful, this project will greatly improve the efficiency of decision-theoretic planning and, in turn, help realize the potential of autonomous agents.  In addition, by automatically i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Perplexity of Parasitism; Co-evolution between Cordyceps fungi and Carpenter ants' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The social insects are among the great achievements of organic evolution and their societies represent a major evolutionary transition in lifes move towards complexity. Consequently, insect societies have historically held a considerable interest for both biologists and lay people. One particularly interesting and rapidly developing field for evolutionary biologists is the interaction between social insects and their parasites. My proposal will be set within this field. I will use the parasite fungus, Cordyceps, as a tool to examine host-parasite relationships within social insects (Carpenter ants; Camponotus genus, from Thailand). This interesting fungus manipulates the behaviour of ants to achieve transmission. I will focus on two key areas that I consider vital to understanding the fundamental evolutionary biology of this relationship: the evolutionary history and the manipulation of host behaviour. For key area 1 I will reconstruct a host-parasite phylogeny, examine prevalence among nests and compare group I intron load with published findings form other insects. For key area 2 I will test two hypotheses relating to the behaviour of infected ants using chemical ecology and population genetic approaches (ant graveyard and Trojan ant respectively).  The work has a number of important interdisciplinary aspects between me, the proposed host (Prof. Boomsma, Copenhagen), his collaborators and two prominent Cordyceps biologists. All of which increases the potential of me successfully carrying out the stated objectives within the time frame laid down. This proposal is coherent with my research profile but, importantly, will give me advanced training in core scientific skills (phylogenetics, chemical ecology and population genetics). I will also gain important complementary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structure-performance relationships in porous carbons for energy storage' in the context of a Horizon 2020 call.

assistant: **Objectives**

Supercapacitors are of great interest as energy storage systems because they exhibit very high rates of charge/discharge, long cycle lifes, and they are made of cheap and light materials. These attractive properties arise from the electrostatic nature of the charge storage which results from ion adsorption in the electrode pores. Recently, it was demonstrated that ions can enter pores of sub-nanometer sizes leading to a huge increase of capacitance. This was an important breakthrough as the energy density of supercapacitors, relatively low compared to batteries, is what currently limits their application. The progress towards more powerful supercapacitors is limited by our incomplete understanding of the relation between their performance, in particular their capacitance and charging rate, and the complex structure of the porous carbon electrodes. To make progress we need a better fundamental understanding of the ion transport and electrolyte structure in the pores but we are lacking the experimental and theoretical methods to do so. The aim of SuPERPORES is to carry out a systematic multi-scale simulation study of supercapacitors. The use of combined molecular and mesoscopic simulations will allow us to calculate the capacitive and transport properties of a wide range of systems. Molecular simulations will be used to model ordered three-dimensional porous carbons. This will allow us to vary geometric descriptors, e.g. pore size and ion size, in a systematic way and obtain relevant microscopic information for the subsequent computational screening of porous carbons, achieved through very efficient lattice simulations. We will then be able to formulate design principles for a new, and much improved, generation of supercapacitors. The simulations will also provide other m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Magneto-Mechanical Technology for Bioinspired Material Testing and Ex-Vivo Diagnosis' (MAGMATED).

assistant: **Innovation**

Natural hydrogels and bioinspired soft materials are changing paradigms in regenerative medicine, drug delivery, microfluidics andsoft robotics applications. Their use requires a comprehensive mechanical characterisation over time that is currently limited by theneed of several and costly experimental setups. These equipment faces difficulties for imposing hydrating and thermal conditions,and for gripping samples during testing without damaging them or introducing undesirable stress concentrations that compromisethe validity of the results. Another research area that faces the same issues and limitations is the mechanical testing of ex vivo tissuefor diagnosis. MAGMATED platform will comprise an intelligent system and integrated data-driven method to mechanicallycharacterise soft materials and biological tissues, providing a fast spatial distribution of apparent stiffness and viscoelastic properties.It builds on our results on magneto-active polymers (MAP) and magnetic actuation control to induce deformation under realistic invitro conditions. The platform will integrate MAPs as sample holders with a computational framework combining data-driven andphysical models to determine the spatial distribution of mechanical properties, from recorded deformation images. Multiple forcecombinations on the sample, along with inverse engineering approaches, will enable a comprehensive and accurate spatialcharacterization surpassing existing methods. MAGMATED has the potential to significantly reduce testing times and costs formechanical characterisation of soft biological materials and tissues, providing a portable platform that does not require extensiveuser’s expertise. We expect a profound impact on testing and design protocols in bioinspired scaffolds, regenerative medicine ordia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assessment of the Uncertainties in Risk Analysis of Chemical Establishments' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The project will address the research area on industrial safety, specifically the examination of vaIiations in safety hazard and risk analysis in Europe, across a range of risk sources building on the basis of current and previous European research initiatives, including comparison and examination of deterministic and probabilistic methods for analysis of public risk from chemical plant hazards. Risk assessment has proven to be a powerful tool in controlling the risk of major accidents in industrial installations. The assessment of the uncertainties and of the way these can affect the final outcome of risk studies is the main scope of the project. All types of uncertainties will be addressed, including the different approaches used, (e.g. probabilistic, reference scenarios, etc.). The objectives of the proposal are: (i) to assess the state-of-the-art of risk analysis in the European Union (ii) to investigate the approaches used to deal with the uncertainties (iii) to describe the quality of risk analysis techniques by assessment of related uncertainties (iv) to investigate and gain insight on the approaches, techniques, models and assumptions applied, to be able to explain discrepancies and deviations (v) to investigate the benefit from the use of risk assessment techniques in specifying risk reduction measures The objectives will be met through the use of benchmark exercises, i.e. case studies carried out by different risk analysis teams independently. A reference plant - an ammonia storage facility - will be analysed by all partners and used a framework for the benchmarks on the elements with an impact on the uncertainty. The outcome of the project will be a higher level of understanding the various parameters and issues that influence the estimation of risk and there
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multiscale and Distributed Computing Algorithms for Biomolecular Simulation and Efficient Free Energy Calculations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The long-term goal of our research is to advance the state-of-the-art in molecular simulation algorithms by 4-5 orders of magnitude, particularly in the context of the GROMACS software we are developing. This is an immense challenge, but with huge potential rewards: it will be an amazing virtual microscope for basic chemistry, polymer and material science research; it could help us understand the molecular basis of diseases such as Creutzfeldt-Jacob, and it would enable rational design rather than random screening for future drugs. To realize it, we will focus on four critical topics:  • ALGORITHMS FOR SIMULATION ON GRAPHICS AND OTHER STREAMING PROCESSORS: Graphics cards and the test Intel 80-core chip are not only the most powerful processors available, but this type of streaming architectures will power many supercomputers in 3-5 years, and it is thus critical that we design new “streamable” MD algorithms.  • MULTISCALE MODELING: We will develop virtual-site-based methods to bridge atomic and mesoscopic dynamics, QM/MM, and mixed explicit/implicit solvent models with water layers around macromolecules.  • MULTI-LEVEL PARALLEL & DISTRIBUTED SIMULATION: Distributed computing provides virtually infinite computer power, but has been limited to small systems. We will address this by combining SMP parallelization and Markov State Models that partition phase space into transition/local dynamics to enable distributed simulation of arbitrary systems.  • EFFICIENT FREE ENERGY CALCULATIONS: We will design algorithms for multi-conformational parallel sampling, implement Bennett Acceptance Ratios in Gromacs, correction terms for PME lattice sums, and combine standard force fields with polarization/multipoles, e.g. Amoeba. We have a very strong track record of converting methodolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The European strategic research Roadmap to ICT enabled Energy-Efficiency in Buildings and construction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of the REEB project is to facilitate co-creation of a Strategic Research Agenda (SRA) and a supporting Implementation Activity Plan (IAP) for sustainable and energy-efficient smart building constructions by and through the establishment of and federation of dialogue between interactive and complimentary communities of practice from energy, environment, and building construction domains.  REEB will establish a community operating method that will allow these communities to act as breeding and nurturing grounds for innovation in bringing together the relevant organisations and stakeholders for the purpose of starting up innovation cycles in ICT-based environment management and energy efficiency" in smart building constructions. The main outcomes will be (i) a SRA and detailed IAP for RandD and innovation in ICT supporting energy-efficient smart facilities, (ii) a comprehensive coordination of information exchange and dissemination between energy-related ICT projects in various EU, national, and global programs/initiatives, in terms of on-going research, developed solutions, standardisation efforts, etc.. This will include organising events and communication channels for identifying, defining, promoting and stimulating the innovative use of ICT in the Sustainability and Energy Efficiency area to reach the widest audience and bring together all stakeholders from the enlarged EU and relevant global communities. The REEB consortium involves 8 partners with complementary expertise drawn from 6 European countries (France, Finland, Spain, Ireland, UK, Germany). Moreover, the core partners, in their effort to build up the REEB community and develop the vision, roadmap and implementation plan, are supported by this Special Interest Group (SIG) whose members (both RTD and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Dissecting Brain Pollutant Exposure and its Contribution to Neurodegeneration and Alzheimer’s disease: From Signatures to Prevention Strategies to Protect and Maintain a Healthy Brain'.

assistant: **Objectives**

Human populations are impregnated by various types of chemical pollutants reported as “hazardous waste” present in the environment. Certain pollutants have adverse effects on brain, but the underlying mechanisms and time-window exposures are still unknown, as well as their contribution on dementia, the 7th leading cause of death. EXPOSIGNALZ project aims to delineate the impact of a selection of environmental pollutants on brain health throughout life and their role in dementia especially Alzheimer’s disease (AD) representing about 70% of dementia cases. Through interdisciplinary approaches, integrating experimental and epidemiological studies, our objectives are to: 1) Identify environmental pollutants likely to have neurotoxic effects and pro-amyloidogenic properties predictive of a neurodegenerative trajectory related to AD using in vitro screening models; 2) Characterize pollutant signatures associated with brain aging and AD in biological matrices of 4 European population-based cohorts of various age groups; 3) Understand the mechanisms of action of pollutants identified in the in vitro screenings and those found in biological signatures, using AD-iPSC and AD preclinical models; 4) Explore the impact of pollutants on early neurodevelopment as a factor of susceptibility for later neurodegenerative diseases using brain organoids and gestational contamination models and 5) Disseminate knowledge to policy makers, to the relevant stakeholders and general public in order to define guidelines for disease prevention and take actions for population’s health. The project, which aims to identify chemical pollutants as new risk factors  for dementia as well as  new pollutant-associated biomarkers, could contribute to: (i) reduce or delay the incidence of AD, and thus reduce th