RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Functional, Mature In vivo Human Ventricular Muscle Patch for Cardiomyopathy' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Developing new therapeutic strategies for heart regeneration is a major goal for cardiac biology and medicine. While cardiomyocytes can be generated from human pluripotent stem (hPSC) cells in vitro, it has proven difficult to use these cells to generate a large scale, mature human heart ventricular muscle graft on the injured heart in vivo. The central objective of this proposal is to optimize the generation of a large-scale pure, fully functional human ventricular muscle patch in vivo through the self-assembly of purified human ventricular progenitors and the localized expression of defined paracrine factors that drive their expansion, differentiation, vascularization, matrix formation, and maturation. Recently, we have found that purified hPSC-derived ventricular progenitors (HVPs) can self-assemble in vivo on the epicardial surface into a 3D vascularized, and functional ventricular patch with its own extracellular matrix via a cell autonomous pathway. A two-step protocol and FACS purification of HVP receptors can generate billions of pure HVPs- The current proposal will lead to the identification of defined paracrine pathways to enhance the survival, grafting/implantation, expansion, differentiation, matrix formation, vascularization and maturation of the graft in vivo. We will captalize on our unique HVP system and our novel modRNA technology to deliver therapeutic strategies by using the in vivo human ventricular muscle to model in vivo arrhythmogenic cardiomyopathy, and optimize the ability of the graft to compensate for the massive loss of functional muscle during ischemic cardiomyopathy and post-myocardial infarction. The studies will lead to new in vivo chimeric models of human cardiac disease and an experimental paradigm to optimize organ-on-organ cardiac tis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A European Benefit-Tax Model and Social Integration: A Preparatory Study' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This Thematic Network aims at: Examining the technical feasibility of constructing an integrated European policy simulation model based on micro-data for the analysis of the impact of policy on social integration at both national and European levels. This objective will be achieved by collecting the information necessary to assemble the components of the model.The preparatory study will examine design strategy and feasibility in the following six areas: data availability, data comparability, policy structures, data-policy compatibility, behavioural response and computing strategy. To perform the simulation of the impact of existing national policy and policy directions at a European level, the micro-data need to contain appropriate informaton for each household (or groups of similar households). Establishing the extent to which available data are sufficient for each area of policy simulation and defining which policy areas may be modelled in a common way acrosss countries is at the heart of the model building project. In order to establish to what extent the paper exercise that is designed for all 15 countries does detect all the problems that would be encountered in the practical construction of the model, two practical case studies will be carried out (for UK-France and Germany-UK) using national micro-data and subsets of policy areas. Establishing the need for such a model among potential end-users, including:  - European Commission services; - European Trade Union Federation (ETUC); - European Employers' Organisation (UNICE); - OECD; - ILO; - Consumer organisations (national and international); - Non-gouvernmental organisations (family and pensioners' associations, women's lobbies etc: national and international); - National fiscal administrations, social security a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Maximising Impact of Prescription Drugs in Rheumatoid Arthritis' (SQUEEZE), addressing dissemination and exploitation.

assistant: **Impact**

The SQUEEZE consortium comprehensively addressed how biomarkers can be used to optimize disease modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis (RA). RA is a chronic immune-mediated disease with enormous health-related quality of life and socioeconomic impact. A broad choice of DMARDs with different targets is up to date available in clinical care, however without sufficient markers indicating the best choice for a particular patient, treatment strategies can be ineffective, cumbersome and expensive. The team of leading academic centres with a first-class record in translational and clinical research, together with patients and small and medium sized enterprises (SMEs) has set out to deliver a collaborative programme to advance the clinical application of biomarkers to improve benefit, safety, and value of approved DMARDs. SQUEEZE utilizes models from data science, clinical trials, translational science, and behavioural science to engage in a complementary, synergistic, and non-overlapping manner addressing the use of biomarkers to improve the ability to select the DMARD with the highest likelihood of fitting the immunophenotypic and clinical profile of the patient, to optimise dose and route of existing DMARDs; and to inform an innovative model of care focusing on patient´s preferences and needs to increase adherence to prescribed drugs. Through nine dedicated work packages SQUEEZE integrates to validate clinical, laboratory, molecular, digital and behavioural biomarkers to enable the recognition of patients with high likelihood of response to treatment and the selection of the drug with highest chance of benefit for an individual patient; and as such improve efficacy and safety of existing therapies (by squeezing the most out of existing drugs) in syne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Human IMMune profiling of Graphene NanoRibbons' to be submitted under Horizon 2020.

assistant: **Abstract**

To promote the Safe and Healthy use of ‘Future and Emerging Technologies’ such as innovative carbon-based nanomaterials, the study of their interactions with blood immune cells is of fundamental importance for any translational medicine application, in particular, those requiring intravenous injection.Taking Graphene Nanoribbons (GNRs) as model, IMM-GNRs will overcome the limits of conventional nano-immunotoxicology to achieve a comprehensive picture of their immune activity in relation to their structural properties (shape, edge structures, width, size…), enhancing the EU excellence in 2D materials research.IMM-GNRs Specific Objectives are:1° To design and synthetize a wide variety of highly stable and water-soluble GNRs2° To perform quantitative GNRs deep immune phenotyping on 17 diverse immune subpopulations, demonstrating the potential of a forefront approach coupling an array of high-throughput technologies3° To correlate immune phenotype and physicochemical properties, investigating the potential molecular mechanisms underlying the observed immune-functions, in order to provide an outstanding paradigm shift in the nanomaterials engineering and classification proposing the novel “immunity-by-design” concept.IMM-GNRs multidisciplinary action will provide the fellow with new career perspectives and contribute to European excellence and competitiveness by:I. Developing expertise in cutting-edge technologies whose diffusion is still limited in Europe; the lack of EU experts make the Fellow’s experience (she will be the first worldwide to apply CyTOF technology to the nanoworld) an high added value to European Academia and Industrial sector;II. Setting long-term collaborations among leading groups of nanotechnology and cell biology;III. Gaining exposure to the industria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Determination of physiologically relevant RNA substrate(s) and design of small-molecule inhibitors for Zα domains as potential intervention strategies for viral infections and autoimmunity' under Horizon 2020.

assistant: **Concept**

DNA/RNA molecules adopting the Z-conformation have been known to possess immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the interferon induced form of the RNA editing enzyme ADAR1 (p150), Z-DNA binding protein 1 (ZBP1), the fish kinase PKZ and the pox-virus inhibitor of interferon response E3L, indicates important roles of Z-DNA/RNA in immunity and self/non-self-discrimination. Such Zα domain-containing proteins recognize Z-DNA/RNA in a conformation-specific manner. Recent studies have implicated these domains in viral recognition. Given these important emerging roles for the Zα domains, it is pivotal to understand the physiologically-relevant nucleic acid substrate for them. In this proposal, we propose to deduce the physiologically relevant substrates for Zα domains from ADAR1 p150 and ZBP1 employing next-generation RNA-seq methodologies. Knowledge on the biochemical and structural aspects of substrate specificity and substrate recognition by these domains would yield important insights into the specific roles these proteins play in the physiological context and would propel efforts at designing effective and specific small-molecule inhibitors against these proteins. Utilizing next-generation virtual ligand screening approaches and high-throughput experimental screening, efforts would be undertaken to discover potential binders/inhibitors of these domains. Small-molecule inhibitors of this domain have potential applications in anti-viral treatments especially against viruses such as influenza and human immunodeficiency virus that have huge human and economic impact as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel Ozone and Thermal Shock Conservation Process for Vegetables' (SCHOCKO3).

assistant: **Concept**

FIORDELISI, leader in the production of dehydrated vegetables in Italy and the first in the production of sun-dried and semi-dried tomatoes was created on 1960. Around 3,500,000 square meters of fields cultivated under Fiordelisi’s careful supervision and an annual production capacity 1,200 tons of sun-dried tomatoes, 700 tons of semi-dried tomatoes, 200 tons of artichokes and 500 tons of other vegetables show our business development. In order to offer always high quality food products, we start by a targeted seed selection and we use modern processes of sanitation and storage, which are constantly studied and improved. Now, we have developed SHOCKO3: a novel sanitation and preservation process based on ozone and a thermal shock. We envisage that SHOCKO3 will replace all traditional oil and freezing based conservation methods. SHOCKO3 will offer approx. 35% of weight reduction, 20% transportation energy saving, 30% CO2 emission reduction, 35% reduction of raw material (oil method replacement), 15% increase average of organoleptic properties (20% taste, 5% colour and % 15 odour) with shelf-life up to 5 months.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DEMONSTRATION OF HIGH PERFORMANCE PROCESSES AND EQUIPMENTS FOR THIN FILM SILICON PHOTOVOLTAIC MODULES PRODUCED WITH LOWER ENVIRONMENTAL IMPACT AND REDUCED COST AND MATERIAL USE' (PEPPER) under Seventh Framework.

assistant: **Objectives**

Improving the cost-competitiveness and approaching grid-parity are the major challenges for micromorph thin-film photovoltaics. This project tackles major factors relating to micromorph module efficiency and production cost by assessing the influences of glass, TCO and silicon deposition (including in-situ cleaning). The project bridges the gap between research and industrial application by executing new developments and improvements in the field of TCO and PECVD reactors and processes and transferring them to production plants where the full impact on module efficiency and costs can be evaluated. On the other hand it also takes some innovations already used in other applications like different glass types and F2 as cleaning gas and transfers these improvements into the photovoltaic application. While different glass types have a high impact on production cost of solar modules, the utilisation of F2 as cleaning gas also has high impact on cost by increasing cleaning rates and decreasing gas cost and also has a strong environmental impact by replacing cleaning gases with a higher global warming potential. All these approaches will not only be developed in parallel but this project will ensure a strong interlink between these activities, e. g. the impact of narrow gap reactors on the F2 cleaning rate. The joint goal of the different work packages is the demonstration of a 157Wp micromorph module with a cost of ownersip (CoO) reduced to 0.5€/Wp. Succeeding in this project will ensure the competitiveness of the micromorph technology and further approach the final goal of grid parity. Having European companies jointly engaged in this project will ensure key players in this important technology branch in Europe, therefore strengthening the European economy. The consortium is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Boosting pan-european Exchange between acceleration ecosYstems for improving quality and Outreach of business acceleration services in Developing innovation ecosystems' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

BEYOND aims to achieve a more interconnected European business acceleration industry in between ‘modest’ or ‘moderate’ and ‘strong’ or ‘leading’ acceleration ecosystems in Europe, and therefore directly contribute to foster the rise of investment flows from net contributor regions (leaders) towards ‘modest’ and ‘moderate’ regions as net beneficiaries, which might provide one effective solution against the above referred undesired geographical gap.  BEYOND project will focus on:  1.- Testing a Self-Sovereign Digital Identity scheme (funding passport) that start-ups get no matter what accelerator they join. Through the funding passport start-ups can document their journey and get access to additional funding; 2.- Building a joint platform for the core acceleration enabling online acceleration and a joint framework for how start-ups are most efficiently developed; 3.- Sharing specific offers from the different project participants and resources to increase the value for start-ups; 4.- Developing an incentive structure where all partners benefit from providing high quality start-ups and develop their services; 5.- Creating a cross-region marketplace for raising funding to start-ups so start-ups are not as dependent on the local investor landscape.  These 5 elements constitute the backbone of BEYOND’s Virtual Accelerator Marketplace (VAM) a trust framework to support joint business acceleration activities that will contribute in a sustainable manner to enhance a balanced interconnectedness of private investment flows and thus, contribute to dramatically improve quality and outreach of business acceleration services in developing innovation ecosystems. The VAM will be tested through 2 editions of a joint acceleration program co-designed by 5 business accelerators backed on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Geometry and Computational Anatomy' (GEOCA) targeting Horizon 2020.

assistant: **Abstract**

The past decades have brought fascinating technological improvements of medical imaging techniques. This rapid development is accompanied by a growing need for computer based algorithms to align and extract markers from medical images. The days of heuristically engineered computer algorithms are, however, over; competitive, state-of-the-art medical imaging software must be based on rigorous mathematics to ensure accuracy, efficiency, and stability.Our research project lies at the forefront of computational anatomy (CA), a truly interdisciplinary field within medical imaging, combining differential equations theory, numerical analysis, computer vision, statistical methods, and differential geometry. CA is an emerging field that harbours a wealth of challenging problems. In particular, to develop image registration algorithms capable of handling heavily nonlinear deformations. In this project we construct image registration algorithms beyond state-of-the-art, adept of tasks where today's methods are inadequate. This is achieved by combining the knowledge of Professor Stig Larsson (scientist in charge) with the knowledge of Dr Klas Modin (experienced researcher).Larsson is a world-leading expert on numerical methods for partial differential equations. He has a large network of international collaborators as well as close connections to the medical imaging industry in Sweden.Modin has extensive expertise on geometric integration (GI), infinite-dimensional geometry, and CA, acquired via two post-doctoral positions at top research groups in two third countries. He thus brings state-of-the-art knowledge to the European research area. In particular, Modin's mastery of large deformation diffeomorphic metric matching (LDDMM) and Euler--Arnold equations is essential; it provides t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pastoralism, Uncertainty and Resilience: Global Lessons from the Margins'.

assistant: **Concept**

Existing institutions, legal frameworks and governance systems are not equipped to respond to growing global uncertainties and the challenges of building resilience. Radical new thinking is needed.  Important lessons potentially can come from surprising quarters. Drawing insights from pastoral areas across three continents, we will ask: What lessons can we learn from pastoral systems responding to rapid change that help us understand how to live with uncertainty and build resilience? Learning from the margins – through a reversal in conventional policy learning and debate - this project will draw out principles from deeply-embedded, culturally-rich responses to rapid change and uncertainty in pastoral areas in Africa (Borana, Ethiopia), Asia (Qinghai-Tibet, China) and Europe (Sardinia, Italy). Working in a world-class team - including the PI (Prof. Ian Scoones), an experienced post-doctoral researcher (Dr Michele Nori) and three PhD students, together with local partners - we will explore how to respond to uncertainty and build resilience across three themes: i) environment and resources, ii) commodification and markets and iii) institutions and governance, while building the interdisciplinary research capacities of the team. Through a process of theory-building, emerging from detailed empirical research in our three sites, we will engage in dialogue with wider debates across five areas – environmental and climate change, finance and commodity markets, infrastructure design, migration policy and conflict and security - about how to respond to risk and uncertainty and build resilience, offering both new theory and practical responses. The research will significantly extend past work through a path-breaking, cross-disciplinary reconceptualization of uncertainty and resili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Isaac Newton Institute for Mathematical Sciences Summer Schools in Mathematical Sciences Framework five series one' in the context of a Fifth Framework call.

assistant: **Objectives**

The Isaac Newton Institute for Mathematical Sciences is an international institute which covers the broad spectrum of mathematical sciences. During 2000 the Institute will hold a number of inter-disciplinary programmes and one Euro Summer School will take place during several of these. The objective is to ensure that the work of the Institute is disseminated more widely in the European Community and that more young people from that community are given the opportunity to participate in a wide range of mathematically-related sciences. The programmes are linked by the fact that they all explore an important topic at the cutting edge of the mathematical sciences but it is expected that different scientists will attend each and hence a large number of young people could be involved in the series as a whole.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00052-1.pdf