RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Numerical characterization and simulation of the complex physics underpinning the Safe handling of Liquefied Natural Gas'.

assistant: **Innovation**

The international commitment to reduce emissions of greenhouse gases has led to a dramatic increase in the use of natural gas (NG). This trend is expected to continue since NG is considered as a vital ally in the search for a sustainable energy future. As Europe is deficient in natural gas resource, the demands need to be met by growing import in the form of liquefied natural gas (LNG). The capacity of LNG to yield large volume of gas (a ration of 600:1 at standard temperature and pressure) has made it an extremely important component of the NG industry but also necessitates high safety standards in its handling. This has led to renewed interest in LNG safety from the energy security and reliability standpoint.The proposed IDP will focus on the numerical characterization and simulation of the complex physics underpinning the safe handling of LNG. The specific objectives of the research include:• To characterize different LNG release scenarios and develop robust source term models;• To gain insight of the complex physics in LNG/fuel cascades and flammable cloud formation, and develop robust predictive tools;• To develop a robust model for accurate prediction of rollover.• To develop modelling strategies for assessing the environmental impact of large LNG spill by coupling micro scale dispersion models with mesoscale atmospheric models; and• To develop and validate LES based predictive tools for large LNG pool fires.The predictive tools to be developed will be validated using published data as well as proprietary data from the private sector Associated Partners, and used to conduct parametric studies as well as safety case studies based on realistic LNG terminal layout.Six ESRs will be trained through the collective effort of well established academic staff (including som
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AI-assisted peRsonalized heart-on-chIp as advanced diagnostic Tool for clinical significance assessMent of Inherited cArdiomyopathies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Inherited cardiomyopathies (iCMPs) are a major causeInherited cardiomyopathies (iCMPs) are a major cause of heart disease and account for a significant percentage of deaths in young patients. While recent advances in next-generation sequencing have enabled testing of a large number of genes related to iCMPs, the rate of identification of pathogenic variants is still below 50%. On the other hand, this unprecedented sequencing power has led to an exponential increase in detecting novel unclassified genetic variants (VUS), for which pathogenicity has not been confirmed. VUS uncertainty of diagnosis poses important problems in clinical evaluations, therapeutic decisions and risk-assessment both for patient and family members.The AI-RITMIA Consortium proposes a breakthrough innovation to establish a conclusive link between specific VUSs and CMPclinical phenotypes, yielding to the development of an unprecedented technological platform: a radically new AI-guided patient-specific heart-on-chip diagnostic tool (AI-RITMIA) will be able to interface for the first time three currently diverging sectors: patient specific in vitro modelling, in silico and artificial intelligence (AI) based data handling and clinical evaluation. AI-RITMIA will be the first clinical grade personalized in vitro-in silico platform enabling faster and unbiased correlations of clinical outcomes with functional in vitro profiling for VUS-carrying patients, returning a pathogenicity score directly to the clinicians to unlock informed diagnosis and therapeutic decisions. The achievement of such innovation will leverage on enabling technologies and resources uniquely available in the Consortium, which brings together excellences from the three interfacing worlds: 1) in vitro models based on OoC and microsensor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Osteoarthritis (OA) is a chronic disease involving the degeneration of articular cartilage and subchondral bone. It represents the single most common cause of disability in older adults. Being aging, obesity, trauma and gender risk factors for OA, its societal burden is rapidly rising. Across EU, over 40 million people are affected by OA. Current treatment options aim at modulating the symptoms rather than curing this chronic disease. Consequently, joint replacement continues to be ultimately the sole option. In this context, MEPHOS aims at realizing an integrated strategy for OA treatment based on the intra-articular deposition of hydrogel, polymeric microplates (uPLs) that could simultaneously provide a long-term pharmacological action and mechanical support. To this end, the uPL geometry and mechanical properties will be rationally selected to match the viscoelastic behaviour of cartilage and synovial fluid. Over the course of several weeks, uPLs will sustainably release clinically-approved molecules for pain management and novel small molecules and biologicals; including chemokine and metalloproteinase inhibitors to halt tissue degeneration; glycoproteins, growth factors and stem cell-derived extracellular vesicles to favour tissue regeneration. MEPHOS involves three EU Academic Institutions and a SME for uPL fabrication, and four US Academic Institutions for uPL biological and preclinical characterization. Through interdisciplinary and intersectoral secondments, this project will support the training of EU scientists on sophisticated in-vitro assays and three different preclinical OA models; foster the rational development of uPLs; and instil a translational research culture to bridge preclinical-clinical boundaries. The inclusion of a SME and the Stanford SPARK Tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Investigation of the mesoscale couplings in nanofluidics using nonlinear optical techniques' in the context of a Horizon 2020 call.

assistant: **Objectives**

Transport of fluids and ions confined at the nanoscale strongly deviates from the continuum description of hydrodynamics. These exotic nanofluidic properties take their roots in the combination, at the nanoscale, of physical phenomena such as charge effects, fluctuations or fluid slippage. Such effects can be harvested for applications such as desalination, blue-energy production, or ultrafiltration for healthcare. Recently, it has been discovered that beyond the chemical reactivity of interfaces, the electronic properties of the confining materials also strongly modify nanofluidic transport. The aim of this project is to understand the molecular nature of these couplings happening at the mesoscale, where the atomic scale of electronic properties meets the bulk scale of the continuum and classical physics of electrolytes. This requires to develop new experimental tools to go beyond the state-of-the-art techniques mainly based on current measurements. Indeed, despite their precision, they only quantify charge transport regardless of the species involved and cannot distinguish water/surface (slippage) from ion/surface interactions (surface charge). To disentangle these effects, we will use new fast nonlinear optical techniques to reveal the molecular nature of the couplings inside channels (nanotubes and 2D channels) made of hexagonal boron nitride (hBN) and graphite. These twin materials will allow us to probe the electronic nature of the couplings: indeed, they share the same crystallographic structure but differ by their electronic properties (insulator versus conductor). We will focus in particular on two objectives: (i) developing a label-free (pump-probe) method able to measure nanoflows in situ and using it to study the effects of ion density, walls’ electronic pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Genetic Analysis of the host-pathogen interaction in tuberculosis'.

assistant: **Objectives**

We propose to extend an existing collection of DNA extracts from TB patients and their corresponding TB DNA to establish the world’s largest resource of extracts from a population of TB patients and 5000 ethnically matched healthly controls.  The bank will comprise 5000 DNA host DNA extracts paired the DNA and cultures of the strain of Mycobacterium tuberculosis causing their disease.  We will perform a genome-wide scan to discover human genes predisposing to TB.  We will then localise causal variants and study their role in a case-control population TB sample from another high incidence country in Africa ,Ghana. We will extensively characterise TB strains from a population in Russia using spoligotyping, minisatellite analysis, and  SNP analysis of genes putatively associated  with virulence and analyse the host-pathogen interaction identifying mycobacterial genes affecting the course of TB, the innate response to TB and outcome at a genetic level.   Based on the existing collection of matched host-pathogen DNA we will perform functional experiments of the role of identified mycobacterial factors such as PE variants and the effect of this variation on aspects of innate immunity as influenced by newly-identified TB-associated genes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DEMONSTRATION OF TWO UNITS OF 1 MW WIND TURBINES OF GERMAN-IRISH CO-PRODUCTION IN THE IRISH WIND REGIME' in the context of a Fourth Framework call.

assistant: **Objectives**

Demonstration of two units of the latests generation of large size wind turbines (MW class) under the specific conditions of Ireland to optain operational data and reliability information by correlation of data from one machine against the second machine as further reference for the successful marketing and series coproduction of the HSW 1000 at minimized costs in the German and Irish shipyards.The use of wind energy is policy in the EU member countries to reduce CO2 emission. Areas for installation of wind turbines get more and more less due to many restrictions. This situation on the one hand asked for the development of large size wind turbines. On the other hand aims this development to lower specific costs of the systems.The installation also shall contribute to the production of pollution-free electricity and give more infromation on the economical use of wind energy in the MW-class under the Irish and UK conditions.At present several MW turbines are being developed and series production has just started. The HSW 1000 has one of the largest experience, but further demonstration, also under different conditions and in different regions is urgently necessary for receiving more reference data and experience; Only the application in a larger scale leads to the economic advantage of significantly lower specific costs during series production itself.Ireland has a good market for wind turbines. The Irish policy asks for Irish content of wind turbines to be installed in the country. This project will be the first cooperation for joint production of large wind turbines between a German and an Irish company. In anticipation of future sales in the Irish and UK market the local production content shall increase substantially. Because of the lower labour costs in Ireland the t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Biophysical Tools to Measure Multiple Parameters In The Same Cell' (SameMultiPhys) under Horizon Europe.

assistant: **Objectives**

Biophysical biomarkers of cell state can reveal physiologically relevant changes that occur during disease progression. For example, cell deformability, cytoskeletal and nuclear organization, and macromolecular crowding are biophysical parameters implicated in migration and growth, which are essential processes for cellular functions. As biophysical parameters reflect physio-pathological cell states, they have the potential to be used as biomarkers for early diagnostics and clinical treatments in medicine. Current techniques based on microfluidics can be used to perform biophysical measurements in a high-throughput manner. However, these systems are not able to provide multiparameter, biophysical and same-cell measurements, making it difficult to find insightful relationships in heterogenous cellular mixtures. SameMultiPhys will develop and produce customized microfluidic systems to measure multiple features in the same cells and evaluate their potential applications as biophysical biomarkers. These new technologies will allow us to study multiscale biological questions of immune T cells from an interdisciplinary perspective and other cell lines. This project aims to facilitate the transfer of knowledge and resources between institutions with expertise in microengineering, materials science, chemistry, mathematics, biology, and biophysics to promote collaboration between researchers, and to develop innovative microfluidic technologies for mechanobiology. The project will involve state-of-the-art microfabrication techniques, deep-learning analysis of images, and computational modelling to develop and validate the technologies developed. The ultimate goal of this project is to gain a deeper understanding of the mechanobiology of cells, enabling progress toward more effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'SHLOW – ‘Show Me How Slow’: Mobilising Evidence from Transport Research into Speed'.

assistant: **Objectives**

There is a well documented relationship between speed and collisions. Excessive and inappropriate speed is the single biggest contributory factor in fatal road crashes. It increases both the risk of a crash happening and the severity of injuries resulting from crashes.   Speed – which encompasses excessive speed (i.e. driving above the speed limits) or inappropriate speed (driving too fast for the prevailing conditions, but within the legal limits) is contributing to as much as one third of fatal accidents and an aggravating fact in all accidents.  Speeding poses particular risks to vulnerable road users such as pedestrians and cyclists as well.   Moreover, speed reduction mitigates the negative environmental impacts of transport. Excessive speed contributes to significant adverse impacts on the environment, as the level of exhaust emissions; fuel consumption and noise emitted by vehicles are closely related to vehicle speed.   Speed has also an important impact on the quality of life in urban areas, where fast moving vehicles can interfere with the quality of life of urban residents.  Mitigating speed is therefore a cornerstone in bringing safety and sustainability together.   The objective of the SHLOW Project is to raise citizens’ awareness on the link between safety and sustainability in transport research and policy by focusing on speed management as a major aspect in preventing road casualties and protecting the environment.   In addition to generally highlighting EU research results in this important area, the European Transport Safety Council (ETSC) and its national member organsations will promote further research into the acceptance and use of ‘speed management technologies’ such as Intelligent Speed Assistance systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Ultra Legionella Inmunoanalysis System for Early Sensing'.

assistant: **Concept**

The general objective of ULISENS project is focused on the development and further commercialization of an automatic early warning system able to detect and quantify Legionella species in water. The system integrates an innovative fast detection biotechnology with an automatic module able to carry out “in situ” analysis in real-time to minimise time to results. ULISENS reduces the legionellosis lethality from 12% to 2% because of TIMELY AND COST-EFFECTIVE INFORMATION to risk owners to take appropriate effective preventive measures as soon as possible. Therefore, it prevents shutdown times and costs, penalties of fines and discredit in face to their customers and the society. The benefit from each early detection using ULISENS (around 120,000€ per case) far exceeds the initial investment (20,000-60,000€). ULISENS technical specifications:- Faster response time, reducing time to result up to 99% compared to laboratory tests - ICT Early warning system to prevent users from infection risks in real time.- Lower cost, with reductions of up to 80% compared with standard laboratory tests - Direct sampling from user’s network in real-time, no technical staff needed.- Sustainable detection biotechnology without maintenance or biological waste generation.- Great reduction of penalties and the discredit of the mark by human infections.BIOTICA is a Spanish company specialized in the development of fast techniques for the microbiological detection and quantification based on the combination of recognition biomolecules, like antibodies, with advanced nanomaterials like paramagnetic particles. Up to now, they have focused on the research and development of the ULISENS system, by means of two R&D regional and national projects  aimed at developing the prototype of the system and to vali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Novel eco-efficient oxidation processes based on h2o2 synthesis on catalytic membranes'.

assistant: **Innovation**

The project will develop advanced catalytic materials for and prove the concept of an integrated technology for eco-efficient reactions of selective oxidation using H2O2. The integrated technology is based on a first stage of synthesis of H2O2 from hydrogen and oxygen using an advanced membrane catalytic reactor and a second integrated stage where the produced H2O2 is used for epoxidation and hydroxylation reactions of industrial relevance. The advanced materials related to the catalytic membrane and metallo-silicate nanocomposite catalysts used in these two stages of the integrated process. The technology is foreseen for both phenol synthesis and epoxidation or hydroxylation of substrates of interest for fine chemical productions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Assembly and function of the crenarchaeal flagellum' (ARCHAELLUM).

assistant: **Innovation**

Archaea constitute the third domain of life and are believed to be close to the origin of life. They comprise a diverse group of micro-organisms that combine bacterial and eukaryotic features, but also employ many novel mechanisms. They possess a unique cell envelope with a cytoplasmic membrane of ether lipids surrounded by a proteinaceous S-layer and various cell appendages such as flagella, pili and more unusual structures. Studies have shown that the archaeal flagellum is an unique structure as it functionally resembles the bacterial flagellum, but structurally it is a simple type IV pilus. Moreover, we have shown that this type IV pilus can rotate. Therefore I propose to name the archaeal flagellum, the archaellum, as it is fundamentally different from the bacterial flagellum.In this proposal I aim to understand the assembly and mechanism of rotation of the archaellum of the thermocacidophilic crenarchaen Sulfolobus acidocaldarius by using biochemical, genetic and biophysical methods. The main milestons are:- Biochemical and structural characterization of all archaellum subunits- To understand the assembly pathway of the archaellum and the interactions of its differentsubunits- To understand how rotation of the filament is achieved and which subunits are importantfor this movementThis work will identify a new, relatively simple motor complex that has evolved from primordial type IV pili assembly machineries and therefore uncover general principles of macromolecular assemblies at cellular surfaces and a novel mechanism to generate mechanical force that can be translated into movement.""