RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accelerating Differentiable Robot Dynamics Simulation for Advanced Control' (ExTRAORDiNary).

assistant: **Concept**

Differentiable robot dynamics simulation is a crucial enabler of advanced robot control. It is at the heart of both model predictive control (MPC) and learning-based approaches (e.g. reinforcement learning [RL]), which are among the most successful and actively researched robot control algorithms. Increased usage of the computationally demanding MPC/RL controllers has led to a growing need for efficient dynamics simulators. However, existing simulators internally use inefficient high-complexity (worst-case cubic) constrained dynamics algorithms (CDA) and are often inefficiently implemented leading to a slowdown of several factors compared to a fast simulator like Pinocchio.Addressing these concerns, we will accelerate the differentiable simulation through three complementary strategies. We will 1) leverage low-complexity CDAs, 2) use Pinocchio's proven efficient software design patterns and explore further acceleration via code generation computations, and 3) derive efficient algorithms for differentiating through contact simulation.Furthermore, our simulator will solve the nonlinear complementarity problem of frictional contact without making physics-compromising relaxations like existing simulators and will be publicly available as part of the widely used open-source Pinocchio library. By adding key enhancements to Pinocchio, we will make it a viable alternative to the inefficient, but feature-rich software simulators. The visibility, impact and usability of our simulator will be enhanced by addressing some low-hanging fruits in MPC, RL and physics identification applications.This projects contributions will not only pave the way towards fast whole-body controllers and faster and more sustainable RL training (important a time surge of RL research activity), but will a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Two-dimensional magnetic systems with anisotropy'.

assistant: **Objectives**

Applicants are sought to fill two postdoctoral research positions in the computational physics/condensed matter theory groups at the University of Leipzig, Germany, to work on a European Community funded project concerned with calculating thermodynamic properties of two-dimensional magnetic systems with anisotropy using quantum Monte Carlo computer simulation techniques (see http://www.physik.uni-leipzig.de/~janke for more information). Researchers with a Ph.D. in statistical physics or condensed matter theory are encouraged to apply, particularly those with experience in computer simulations of quantum systems. Both positions are for two years, the first starting in 2002. For the second position, starting in 2004, additional research competence in dissipative quantum systems is required. Interested candidates should send a CV summarizing research interests and experience, a list of publications and should arrange to have three letters of references sent to: Prof. Dr, Wolfhard Janke, Computational Physics Group, Institut für Theoretische Physik, Universität Leipzig, Augustusplatz 10/11, 04109 Leipzig, Germany ( e-mail:janke@itp.uni-leipzig.de). The University of Leipzig is an affirmative action/equal opportunities employer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Systemic analysis of chromatin-regulatory genes in PDAC using advanced in vivo RNAi' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death and has the lowest survival rate of all major cancers (3-5%). Despite our advanced understanding of disease pathology and underlying genetics, there are no effective chemotherapeutic or targeted treatment options, and the median survival time remains unchanged at only 6 months. PDAC arises from complex and heterogeneous genetic aberrations, which in a single case typically involve >50 genes. Besides four hallmark mutations affecting KRAS, TP53, CDKN2A and SMAD4, aberrations of the chromatin regulatory machinery are common in PDAC. Chromatin-associated genes are particularly attractive as drug targets, since resulting epigenetic aberrations are reversible and often amendable to drug-based modulation. However, the mechanistic role of chromatin aberrations, as well as their potential as therapeutic targets  have not been explored in PDAC. In order to accelerate the search for more effective therapies for this devastating disease, this project will combine genetically engineered PDAC mouse models, multiplexed RNAi screening and advanced in vivo RNAi technologies to systematically analyze chromatin-regulatory genes in tumorigenesis and maintenance of PDAC. As tractable experimental system for in vivo RNAi studies, I will generate a Tet-on competent PDAC mouse model based on endogenous KrasG12D and homozygous loss of Trp53. Following its characterization, the model will be employed in multiplexed in vitro and in vivo RNAi screens using a new chromatin shRNA library. Selected hits will be functionally characterized using innovative in vivo RNAi approaches. Overall, these studies aim to advance our mechanistic understanding of chromatin (dys)regulation in PDAC, identify new target molecules for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'FAST-BM: FibroSelect: delivering A Step-change in Biotherapeutic Manufacturing' (FAST-BM) under Horizon 2020.

assistant: **Objectives**

Seven of the top 10 global medicines by spending are biotherapeutics drugs, and the market is growing at a CAGR of 10.1% to reach a value of $287 billion in 2020. Challenges facing biotherapeutic manufacture are: i) Chromatographic purification, accounting for >50% of processing costs. This is important given the increasing price sensitivity of payers worldwide and serves as a limitation to the growth of the biosimilar industry; ii) Increasing diversity and complexity of biotherapeutics: ~70% of biopharma’s product pipeline are large complex proteins (e.g. bispecific antibodies, fusion proteins or viral vectors), which offer promising therapeutic opportunities, but cannot be manufactured cost effectively as they do not fit with current bioprocessing platform technologies; iii) Process flexibility: The rapidly evolving industry is moving to more flexible disposable formats to cope with uncertainty in drug development and varying market demand. Puridify has developed an innovative bioprocessing platform technology, FibroSelect, a functionalised cellulose chromatography medium to enable high-productivity, product capture and purification that is economic to operate in a disposable manner. FibroSelect addresses each point above by i) enabling cost reductions of up to 25% (potentially £700K - £2.7m per batch); ii) offering flexibility to design new bioprocessing platforms; iii) being a wholly disposable system where all purifying ligand is expended per-batch purification. It is innovation in the latter area that helps to drive costs down and increase productivity, as the requirement for cleaning columns and re-validating prior to purification of the next batch of biotherapeutic product is ameliorated. FibroSelect eases process constraints and enables flexibility through sing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regional co-operation in the balkans and european integration' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The project involves a 7-month study on regionalism in the Balkans. It is assumed that despite the high level of fragmentation and disintegration in the region, there is also a trend towards regional co-operation, currently under progress. However, for various reasons the progress of regional co-operation has been meagre and slow. The study will attempt to assess the nature of Balkan co-operation; focusing on the current debate on regionalism in South-eastern Europe within the wider European and international context and explore the history of 20th century Balkan regionalism. It will examine local attitudes towards regionalism. It will also assess the links between Balkan regionalism and European integration. This analysis will add to our understanding of a region in need of further co-operation and integration with Europe and to present ideas and policy proposals on the prospects of regional co-operation in the Balkans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computation with real Lie Groups' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Group theory is the mathematical discipline that deals with the systematic study of symmetry. Lie groups are used to describe some of the most complex forms of symmetry. Therefore they find many applications in various diverse areas such as physics and geometry. Since the invention of the computer, it has been used as a tool in the study of group theory and, in particular, Lie groups. This has led to a new research area, called Computational Lie Theory. The main focus in this area has been on complex Lie groups.  However, it would be of great interest to use the computer to study real Lie groups because of the abundance of applications that these groups have in physics and differential geometry. It is the aim of the project ""Computation with Real Lie Groups"" (CoReLG) to start such a development in Europe.  In the U.S.A. a similar project has been set up, called the ATLAS project. In 2007 this project had a huge success, widely reported in the international press, when the so-called Kazhdan-Lusztig-Vogan polynomials were determined for the real Lie group of type E8.  The project CoReLG aims at starting a similar research project in Europe. However, the research goals of the CoReLG project are genuinely different from those of the ATLAS project. The main objective will be to develop algorithms for one of the main problems regarding Lie groups: obtaining their orbits. As this problem is intractable in general, we focus on a special class of Lie groups, namely real theta-groups, which contain many instances of interest. Furthermore, the project aims at implementing these algorithms as a software package for a European public domain computer algebra system, such as GAP. A third goal of the proposed project is to develop applications of the algorithms in differential geomet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Following Protein Diffusion in Photosynthetic Membranes with Super Resolution' (MeaSuRe).

assistant: **Innovation**

The regulated diffusion of light-harvesting complexes in photosynthetic membranes is essential for photosynthesis, for instance for the redistribution of light-harvesting complexes between Photosystems I and II. To date, however, little is understood about the mobility of these proteins through the highly crowded membrane environment. In contrast to the huge amount of structural research that has been performed on biomolecules in the past, research on the dynamics is lagging far behind. The major limitation is the fact that the nanometer size regime of biomolecules is not accessible by classical optical techniques owing to the diffraction limit of light. To overcome this problem, we propose to use plasmonic nanoantennas, which are able to confine light at the nanoscale. In combination with Fluorescence Correlation Spectroscopy (FCS) this will allow measuring protein mobility in photosynthetic membranes with high, tens of nanometers, resolution. Directional and functional protein movement will be induced by illumination of the chloroplasts using specific light conditions; simultaneously following the protein movement will give new insights in how plants optimize their light harvesting capacity under fluctuating light conditions. The new nanoantenna-FCS based method, which we will develop to measure the diffusion of membrane proteins with nanometer resolution, has the potential to become widely used for nanobioimaging and ultrasensitive biosensing.This research will be performed by Dr. E Wientjes in the Laboratory of Biophysics of Wageningen University led by photosynthesis expert Prof. H van Amerongen. A long-term collaboration will be started with Wientjes current supervisor Prof. NF van Hulst and Prof. MF Garcia-Parajo from the Institute of Photonic Sciences in Barcelo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AN ELECTRON BEAMLINE AT THE European-XFEL' (ELBEX) targeting Horizon Europe.

assistant: **Abstract**

One of the highlights of the European research infrastructure landscape is the world's most powerful X-ray-laser, the European XFEL. The ELBEX (Extracted Lepton Beam at the European XFEL) proposal builds on this strength and will set up new opportunities for European scientists and innovators, by providing an extracted high energy electron beam for experiments. With ELBEX we propose a pathfinder project to demonstrate the feasibility of such a facility at the European XFEL. This unique new possibility would strengthen the global competitiveness of the European Research Area and create opportunities for new user groups.The high energy, high charge density and excellent quality of the electron beam, if brought into interaction with a strong laser beam, opens up the study of a range of scientific topics, most prominently, of strong field Quantum Electrodynamics (QED).  For the first time, the Schwinger limit for the electromagnetic field strength, at which non-perturbative QED effects become relevant, could be reached experimentally  in this facility. Studying the particles created in the photon beam dump opens up the possibility to search for feebly interacting particles, complementing current or planned experiments like FASER II or SHiP. In addition, the electron beam itself is at the centre of a range of highly relevant and ambitious experiments in the area of accelerator science and detector science. Within the ELBEX project, the installation of a facility to extract an electron beam from the European XFEL using a fast kicker magnet and to transport it into a multi-purpose experimental area will be prepared. On the condition that a positive decision by the European XFEL council is reached to grant an extended 12-week XFEL shutdown, the installation of the ELBEX facilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Electrokinetic logging tool development for enabling more efficient production from hydrocarbon-bearing formations and groundwater aquifers'.

assistant: **Objectives**

Technically these are to ensure that electro-kinetic logging measurements can be reliably made in a range of subsurface rocks, that the theory is well understood, performance accurately modelled, and that they can be reliably interpreted to give permeability and fluid information. This capability would be a step change improvement over current methods, and the impact in the market of a new method able to offer far more information at lower cost would be considerable.The technology would be anchored in the EU giving a strategic advantage against the competition. It would assist the EU in diversifying its energy supply and maximising development of its own production. Better aquifer management would also be a major benefit to the health of the population dependent on groundwater.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Subregionalised Specification Of Muscle Cell Identity In The Somite' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

I intend to molecular phenotypically analyse transgenic mouse mutants lacking genes implicated in myogenesis. thereby the assumed linkage of the specification of different muscle cell types to distinct myotomal subregions can be tested and mouse models for the aetiology and molecular basis of human progressive muscle diseases are provided.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Unique and Innovative flushing test bench for cleanliness assessment of hydraulic components that allows to increase test efficiency and reduce costs' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Contaminants in hydraulic components cause premature deterioration, resulting in poor performance and failure, not only of the raw components but also of the end-products once assembled. Over 75% of failure events in hydraulic systems are due to contamination. Contaminants increase fuel consumption, energy loss and pollution in combustion engines, while decreasing battery life in electric engines. Thus, all hydraulic manufacturers & assemblers are forced to assess the cleanliness of their products before commercialization. Although some of them invest on heavy equipment for on-site analysis, most of them externalize it to expert labs. Either way, these options fail to meet their needs. Besides being costly & time-consuming, they only assess for contaminants in the final product. This approach prevents users from having a clear view on the sources of contamination affecting their manufacturing chain. In response, we at OilSafe offer CLEAN CABINET, a unique automated system for cost-effective analysis AND removal of contaminants. Our system implements a holistic approach, not only analysing contaminants from products but also characterizing and identifying their origin at the production chain. Besides being simpler and more cost-efficient, CLEAN CABINET allows users to meet the quality required for product certification (ISO16232) and to comply with environmental laws. After validating the functionality of the prototype, we now want to move forward with the project, seeking to finalise its technical development, industrialise manufacturing and prepare for market launch. In Phase 1 we aim to run a Feasibility Study that allows us to gather input and secure the project from all technical, financial and commercial outlooks. Upon completion, we expect CLEAN CABINET to bring s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Alzheimer's Disease (AD) Detect & Prevent - Presymptomatic AD detection and prevention' in the context of a Horizon 2020 call.

assistant: **Objectives**

Alzheimer’s disease (AD) is central to the rapidly growing and crushing ageing challenge that threatens to economically undermine today’s health care system. AD prevalence will grow to over 100m cases in 2050. AD is incurable, but can be prevented. Detecting pre-symptomatic signs of AD in at-risk groups and intervening early may be the only viable solution. Our target is to bring to market a novel ICT tool, named ‘AD Shield’, that screens for and detects pre-symptomatic stage cognitive decline related to AD, and creates a personalized program for each individual user to strengthen weakened cognitive abilities, thus building cognitive reserve and reducing AD risk. Brain+ will collaborate with world leading neuroscientists to validate this ICT tool. Completion of the tasks described in the workplan will secure the remaining development adaptation combination and validation of the existing technological breakthroughs of the Brain+ method and ICT platform, including the Oxford University’s new highly sensitive cognitive assessment method. The end product will be a scientifically validated, effective, economic, engaging and easily accessible method for pre-symptomatic detection of AD and preventative training. 'AD Shield' can be value created and costs saved of up to €60.000 per patient for the healthcare payers, and at EU level saving can amount to €7bn-108bn direct costs per year and €155bn informal care costs per year. Success stemmed from this phase 2 project will also empower AD at-risk groups and allow them to stay active in the labour market for longer. The combination of costs saved will ultimately boost EU competitiveness.


**Keywords:** gamification, applied games, digital brain games, neurodegenerative dissease, ageing, Alzheimer's disease, dementia, cognitive de