RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Science from Nature to your Table' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Science from Nature to your table (Sci-NURTURE) reflects how environmentally sustainable agriculture and food production play an important role in our daily life. We will demonstrate the scientific facts and developments in the human food chains (animal-based, plant-based, and seafood-based) from the very beginning stages in nature through our table. Students, kids, and citizens will go through the story of nature components becoming food on our table by practicing all levels with researchers. This will help increase awareness of the sustainability of natural resources in society. Participants will appreciate the importance of terms such as ""sustainability"", ""water footprint"" and ""consumed energy"". Public awareness for researchers and innovation activities is expected to increase when they become aware of the contribution of scientists in their daily life. The Sci-NURTURE will rely on a wide area of subjects that cover most of the missions and Green Deal issues by practicing and demonstrating those issues to the public. Since the Eastern part of the country is less developed as compared to other regions in the country, science parks and other attraction centers are almost non-existent in the province. The young generation and the kids in the region are eager to see novelties of science and they are longing for any kind of attraction. Having a science-related organization in the city will create huge excitement for the public. By presenting scientific developments in different fields, Sci-NURTURE will provide youth with a path for picking their future profession. Finally, Ataturk University has been a partner of very few EU projects since only a couple of researchers apply for EU funds. There is a hesitation in researchers to go through all steps of getting EU fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A BREAKTHROUGH TECHNOLOGY DESIGNED TO PRESERVE SIGHT AND HALTING VISION LOSS ASSOCIATED WITH A RANGE OF RETINAL DISEASE BY PREVENTING THE DEATH OF KEY RETINAL CELLS .', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

I am the CEO and Cofounder of SeaBeLife, a French biotechnology company developing First-In-Class drugs to treat severe pathologies affecting our vital organs for which there are no effective treatments. We develop an innovative therapeutic approach protected by 4 patents and with a lead program to treat Acute Liver Failure and a second program to preserve sight and halting vision loss associated with a range of retinal disease by preventing the death of key retinal cells. We are developing a first-in-class drug based on a dual-targeted approach, capable of stopping directly and simultaneously two forms of regulated cell death pathways known to be involved in triggering of numerous acute and chronic pathologies and contributing to organ damage. Our molecule protects the cells, prevents tissue damage, and finally preserves and restores organ function. SeaBeLife is the only company worldwide developing such a therapeutic approach. Our molecule has a direct protective effect on cells and has the potential to prevent evolution to severe life-threatening form. We have already obtained very convincing in vivo results in several highly predictive models. Our molecules were tested on pharmacologically relevant murine models and have shown no toxicity and strong efficacy. SeaBeLife is composed of an experienced and complementary operational team managing by two women and supported by a scientific and strategic advisory board with scientific and medical experts of extensive expertise in drug development. We have already raised 4.3M€ to develop our technology and we are ready to bring our molecules to the clinic and validate its safety and efficacy. The main milestones over the next 2 years will be the production of compliant clinical batches and the realization of phase 1 and pha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Doping Colloidal Nanoplatelets: Synthesis, Self-assembly and Spectroscopy' to be submitted under Horizon 2020.

assistant: **Abstract**

Two dimensional (2D) nanomaterials have attracted rising scrutiny from the research community in the last decade due to their outstanding physical, optical and structural properties. Beyond the well-known example of graphene and other exfoliated bulk materials, a new colloidal route has recently emerged towards such materials and offers a high degree of control on the structure of these nanosheets. Among these, atomically flat, quasi-two dimensional, colloidal semiconducting (CdS, CdSe and CdTe) nanoplatelets (NPLs) have very interesting opto-electronic properties. Our goal is to fully exploit the potential of these NPLs by doping them with transition metal ions (Mn2+, Cu2+ or Ag+). With the help of doping in such small systems, we can tune the absorbance, photoluminescence, carrier density and mobility of these materials and extend the potential of these materials for various applications such as field effect transistor, light emitting devices or photovoltaic solar cells. We will devise new synthetic strategies towards doped semiconducting NPLs and characterize their structural and optical and electronic properties using state of the art techniques. Advanced structural characterization (XRD, TEM, STEM) will be coupled to optical spectroscopy (fluorescence lifetimes, absorption, emission and excitation spectra) both in solution and on single objects. Afterwards, we will assemble these thin doped platelets together to form supraparticles and large-scale assemblies using different soft-matter techniques (depletion interaction, polymer grafting, templating by an interface) in order to tune their optoelectronic properties. A fine control of the assembly process would direct to new fundamental collective effects and easy processing and orientation of doped platelets, which i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The evolution of disperal in vertebrates. Reaction norm and pattern of dispersal in three lacertid lizard species' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The aim of the present study is to analyse the dispersal pattern and reaction norm of three species of lizards that differ in their habitat tolerance and explorational behaviour. We will study three related lizard species: Psammodromus algirus, Acanthodactylus erythrurus and Podarcis hispanica, The study will consist of: (I) An experiment of reciprocal transplantation of the I species offspring between two areas of different ecological characteristics that contain the three species. (2) A comparative study of those three species and Lacerta vivipara, which dispersal pattern is already known. (3) A phylogenetic analyses of the patterns of association observed in the groups of related genera: Psammodromus-Podarcis and Acanthodactylus-Lacerta (4) The study of the stopping rules of dispersal movement in Lacerta vivipara and relation to the suitability to settle in a new habitat. Training content (objective, benefit and expected impact) The stopping rules of dispersal movement study in Lacerta vivipara and the analysis of the reciprocal transplantation experiment will be carried out in Paris (France). Field work and offspring monitoring at Spain during the first year breeding season and during the second year breeding season will be carried out in cooperation with a group of students from the Evolutionary Ecology Group in the Laboratoire d'Ecologie' (host institution). Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Domestic and International Determinants of Election Violence' to be submitted under Seventh Framework.

assistant: **Abstract**

Recent elections in Afghanistan, Kenya, the Cote D’Ivoire, Nigeria, and Pakistan experienced substantial violence, yet the causes and consequences of election violence remain poorly understood. This project conceptualizes election violence as a sub-type of political violence in which actors employ coercion to affect the electoral process or that arises in the context of electoral competition. A major difficulty in analyzing its causes and consequences is that no comprehensive data source on the incidence of election-related violence exists. To alleviate this problem, the proposed research project will collect data on election violence for all countries with competitive elections for the 1990-2010 period. Once complete, the data will publicly available. A second objective of the project is to develop theoretical arguments on the domestic and international determinants of election violence. Drawing on existing case study research, the argument posits that the competitiveness and quality of elections affect the likelihood of electoral violence. With regard to the international determinants of election violence, the proposal hypothesizes that the presence of international organizations supervising the electoral process can induce shifts in the use of violent intimidation, thus increasing the probability of violent intimidation in the pre-election period. The final objective is to systematically evaluate the theoretical expectations using data collected by the project.The project will transfer knowledge gained by organizing conference panels, presenting project results at academic conferences, publishing results in peer-reviewed journals, integrating political science students as research assistants, and outreach activities that include meetings with practitioners engaged in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pathways for transitions to sustainability in livestock husbandry and food systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The PATHWAYS project will deliver co-developed transition pathways that directly address societal demands for increased resilience in the provision of safe, nutritious, affordable livestock-based food, whilst reducing environmental impacts, and supporting the economic sustainability of the European livestock sector. Visions, scenarios and transition pathways will be co-developed through an ambitious participatory approach based on innovative practice hubs, living labs and interaction within a European multi-actor platform and a wider community of practice.Existing and future, co-designed livestock systems will be characterised and assessed within a scientifically robust, holistic sustainability assessment framework, comprising refined key performance indicators and cutting-edge models, to enhance understanding of productivity, biodiversity, health and welfare, greenhouse gas emissions, human nutrition, trade and economics, and ecosystem service impacts. Living labs and practice hubs will identify bottom-up interventions and adoption routes that will drive a transition to improved livestock system development. Consumer preferences, diet choices and willingness to pay will be supported by consequential LCA and economic analysis of trade and supply chain impacts, addressed through stakeholder input and modelling. The participatory development and application of a holistic sustainability assessment will deliver a scientifically robust analysis for the co-development of scenarios and transition pathways to inform key stakeholders throughout livestock-based food systems, driving a transition to greater sustainability. PATHWAYS will improve the role of livestock in supporting a circular bioeconomy and the place of animal products in future diets through an interactive online p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Age-Selective Segregation of Organelles'.

assistant: **Innovation**

Our tissues are constantly renewed by stem cells. Over time, stem cells accumulate cellular damage that will compromise renewal and results in aging. As stem cells can divide asymmetrically, segregation of harmful factors to the differentiating daughter cell could be one possible mechanism for slowing damage accumulation in the stem cell. However, current evidence for such mechanisms comes mainly from analogous findings in yeast, and studies have concentrated only on few types of cellular damage.I hypothesize that the chronological age of a subcellular component is a proxy for all the damage it has sustained. In order to secure regeneration, mammalian stem cells may therefore specifically sort old cellular material asymmetrically. To study this, I have developed a novel strategy and tools to address the age-selective segregation of any protein in stem cell division. Using this approach, I have already discovered that stem-like cells of the human mammary epithelium indeed apportion chronologically old mitochondria asymmetrically in cell division, and enrich old mitochondria to the differentiating daughter cell. We will investigate the mechanisms underlying this novel phenomenon, and its relevance for mammalian aging.We will first identify how old and young mitochondria differ, and how stem cells recognize them to facilitate the asymmetric segregation. Next, we will analyze the extent of asymmetric age-selective segregation by targeting several other subcellular compartments in a stem cell division. Finally, we will determine whether the discovered age-selective segregation is a general property of stem cell in vivo, and it's functional relevance for maintenance of stem cells and tissue regeneration. Our discoveries may open new possibilities to target aging associated fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Infants predicting own and others’ actions: the neurocognitive development of action prediction'.

assistant: **Concept**

Predicting others’ actions is crucial for acting in a social world. How we come to these predictions is hotly debated. The simulation account states that the motor commands used to predict the sensory consequences of our own actions are also used to predict others’ actions. In contrast, rationality theory suggests that predictions of others’ actions are based on inborn, abstract rules and thus rely on a different mechanism than predictions of our own actions. To address this controversy, I suggest to study how predictions of own and others’ actions develop during infancy. In Study 1, infants of 6- and 12-months of age will reach and grasp for objects, and observe someone else reaching and grasping for objects, while their hand and eye movements are tracked. Hand and eye movement tracking can reveal whether and when infants predict the goal of the action. Results will reveal whether the two types of predictions develop in synchrony. Study 2 tests the congruence in brain activation between reaching performance and observation while infants’ brain responses are measured using fNIRS. Study 3 will verify whether the basic mechanism found for predicting others’ simple reaching actions also applies to a real-world situation involving multiple objects and a sequence of reach and grasp actions, such as sandwich making. To this end, 3-year-old children will be asked to make a sandwich and to observe someone else making a sandwich while their eye and hand movements will be tracked. Taken together, the three proposed studies will show whether the same or a different neurocognitive mechanism serves to predict own and others’ actions and whether this mechanism extends to real-world applications. If so, this mechanism can enable people to understand each others’ behaviour. The finding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Spatio-temporal Control of Cell Division in Fission Yeast' (SpTpCdr2).

assistant: **Concept**

Cytokinesis is a critical and irreversible step of cell cycle, which eventually separates daughter cells. This event is consequently subject to strict spatial and temporal regulations. Spatial integration of the DNA distribution and the global geometry of the cell are necessary to determine the proper division plane and ensure the successful genome and cytoplasmic segregation. Additionally, cells of a given cell type usually grow to a similar size, suggesting that cell dimensions can be monitored and controlled. Consequently, coordination of cell growth and cell division is essential for an appropriate cell size homeostasis. The fission yeast SAD kinase Cdr2 assembles a novel structure termed “midsome”, which is organized as medial cortical nodes. This structure includes a variety of proteins, including the anillin-like protein Mid1, a key factor in division plane positioning, and Wee1, which inhibits the entry into mitosis by phosphorylating Cdk. Two recent articles have demonstrated that the DYRK kinase Pom1 phosphorylates Cdr2, inhibiting it and excluding it from the cell tips. A gradient of Pom1 from the cell tips allows a differential inhibition of Cdr2 depending on its distance to the cell tips, thus, coupling cell size to the determination of the division plane and the cell cycle progression. Therefore, I propose to study the assembly and maintenance of the “midsome” analysing Cdr2 anchorage to the membrane, the molecular mechanism underlying the phosphorylaton of Cdr2 by Pom1, and the importance of membrane lipid composition on the localization of the “midsome”. Defining the role of the Cdr2 kinase in reading the spatial cues given by the cell tip protein Pom1 will also contribute to a better understanding of intracellular signals that trigger entry into mitosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elucidating the Superior Colliculus-related network properties and modulation in Huntington's Disease mouse model to delay the onset and ameliorate severity of the motor symptoms' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Neurodegenerative movement disorders e.g. Huntington’s Disease (HD) predominantly involve progressive motor symptoms as a result of disrupted basal ganglia neuronal networks. These symptoms are accompanied by early occurring deficits in visual perception and oculomotor functions, which share neuronal circuits with motor domains, and can be used in the prediction of the onset and severity of HD pathogenesis. Therefore, understanding the early circuitry alterations in HD progression is crucial to develop new disease-modifying strategies. The superior colliculus (SC) is a sensorimotor structure that receives and integrates visual information to control reflexes and is involved in visual perception and oculomotor functions. Functional MRI and behavioural studies demonstrated that the HD symptomatic mouse model show alterations in the SC function, but its role in motor symptoms has not been directly addressed. The HD-SC project proposes that (i) SC is an important factor in the basal ganglia circuit alterations found in HD, (ii) topographically segregated SC outputs provide differential contributions to the motor and defensive behaviours, and (iii) temporal control of SC neuronal plasticity with novel phytochromes will cause delay and amelioration in motor symptoms in HD model. This will be addressed using a combination of mouse behavioural, histological and biochemical phenotyping to reveal the onset of SC-related alterations in the HD model. Then, by using DREADDS we will determine the differential representation of SC outputs in motor and defensive behaviour. Finally, we will test the capability of phytochromes to modulate SC neuronal plasticity and delay and ameliorate motor symptoms in the HD model. Overall,  the HD-SC aims at bringing a spotlight to mechanisms causing