RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Digital transformation journey for SMEs'.

assistant: **Innovation**

The digital transformation of EU business and society presents enormous growth potential for Europe. It is estimated that digital technologies, such as Big Data Analytics, Artificial Intelligence or the Internet of Things, have the potential to add 1.5 million jobs to the EU’s digital economy, and that SMEs can grow two to three times faster when they integrate digital technologies into their business models. Nevertheless, on the one hand, SMEs are not currently taking full advantage of these advanced technologies because they usually lack orientation, know-how and hands-on solutions in line with their current business, and on the other hand, digitalisation services in too many occasions do not take into account the rapid changing innovation ecosystem and the emerging of new technologies.The objective of DigiJourney is to enable the participating innovation agencies to exchange knowledge, know-how, and good practices on advanced methodologies and tools for digitalisation assessment to SMEs and customised support services. In particular, based on the Twinning+ methodology, the project aims to cover peer learning activities for three digitalisation approaches and the design of a digitalisation journey for SMEs, which will facilitate all innovation agencies to improve their digitalisation support services adapted to their specific national/regional contexts, and will allow SMEs to get the right digital tools to gain competitiveness. This peer-learning and peer-review scheme has been developed based on each partner's identified competences in advanced digitalisation services for SMEs. DigiJourney will therefore contribute to the specific challenge of increasing SMEs support programmes and the satisfaction of them with the support provided, through a joint learning effort of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Innovative alkaline earth systems for the activation and functionalization of dinitrogen and other challenging substrates'.

assistant: **Innovation**

Catalysis is a powerful tool to address profound challenges in Europe’s energy transition. However, many current catalytic systems face important limitations in relation to activity, selectivity, or cost efficiency. Particularly, the production of ammonia relies upon the century-old energy-intensive Haber-Bosch process, which is estimated that consumes up to 3% of the global energy produced every year. This EU-funded AE-FUN project will develop innovative systems based on earth-abundant, readily available alkaline earth metals for the challenging conversion of  dinitrogen into ammonia and other nitrogen-containing valuable chemicals. This will be achieved by harnessing the unexplored modes of cooperativity between transition metals and low-valent alkaline earth elements. We envision that unusual participation of d the orbitals from the Ae element and the redox activity of transition metals will give place to unseen synergies that will facilitate the activation of highly challenging substrates (N2, CO2, CO, H2) and their functionalization.


**Keywords:** main group chemistry, bimetallic chemistry, alkaline earth metals, nitrogen reduction, homogeneous catalysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable production, Physiology, Oceanography, Natural products, Genetics and Economics of Sponges' (SPONGES).

assistant: **Concept**

Many marine sponges contain natural compounds that have potential interest to society. Limited possibilities for supply of these compounds from natural resources often delays or even stops further development of a product after its initial discovery. In the proposed project, systems and processes for the cultivation of marine sponges will be developed in order to create a stable and sustainable supply and reduce pressures on natural resources. The development of these applications will be supported by studies on the biology of the target organisms, such as ecology, feeding biology (and the role of symbiotic microorganisms therein) and ATP-metabolism. In addition, the genetic background of growth and secondary metabolism of sponges will be studied in order to rationalise strategies to improve culture techniques. The culture systems to be developed are an integration of innovative technologies of four European SMEs, including novel strategies to feed sponges in closed and half-open systems, a unique technology to control water quality in artificial marine systems, novel spectrometric sensor technology (and corresponding software) to monitor and control the system, an in vitro sponge cultivation system (primmorphs) for testing medium design and specific sponge farming methodologies. A limited number of (commercially interesting) sponge species will be used in the project as model species for technology development. Product formation in these species will be studied in order to optimise productivity of the culture systems. The objective of the proposed project is to initiate a sustainable sponge industry in Europe by combining the efforts of innovative SMEs and leading scientific institutes. The project will strongly improve the competitive position of Europe in marine biot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A developed thermochemical approach for catalytic depolymerization of plastics' (CATALEPTIC).

assistant: **Innovation**

Plastics-waste issues such as climate change, energy depletion, and environmental pollution are long-term challenges. To meet the target 60 % plastics recycling by 2050, a disruption of the current plastics economy seems unavoidable. Mechanical recycling, as the most popular approach worldwide, is currently limited to a restricted number of high-purity Polyolefins. As a green chemistry method, plastic depolymerization exploits the unique hydrothermal properties of near-critical water for circular chemical recycling. However, in its current state, economic and technical bottlenecks stall the technology maturation.Catalytic depolymerization of plastics in hydrothermal media, CATALEPTIC, is planned to ease the depolymerization of common plastics, including addition and condensation polymers, into monomeric/Naphtha production. Professor Lasse Rosendahl and Assoc. Professor Thomas Helmer Pedersen, will supervise and guide me to achieve beyond state-of-the-art results to radically change the way plastics will be handle in the future. In close collaboration with Haldor Topsoe and Technical University of Munich, as the project secondmentw, this research plan will combine my expertise in catalysis, Reaction Engineering, and Process Chemistry with the host’s expertise in the hydrothermal valorization of wastes to equip the infrastructure existing in AAU, host organization, for continuous HTL of waste materials with both active and highly selective catalyst and a state-of-the-art purification system. This program will not only allow me to diversify my competence by acquiring new skills and competencies, particularly in terms of demonstration engineering, catalyst application, and purification systems, which will also enormously benefit my inter-sectoral and interdisciplinary exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart Loyalty Program: Using Data Science to Inspire the Next Purchase' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Credit and debit card transaction histories are a valuable source of information about their owners’ purchase patterns. This information can be used to accurately address promotional offers, called Card Linked Offers (CLO). Today, CLO performance is limited due to the nature of accessible information from credit cards: it is often fragmented and and is not customer-centric as it does not take into account habits / historic of purchase to develop personalized recommandations. It is basic coupon with no intelligence.PayLead is a French SME founded in 2016 developing a new approach - called Account-Linked Offer (ALO®) - that allows all transaction data to be collected, not only bank card payments. ALO is based on cross-checking transaction data with several external sources making it possible to improve prediction relevance and accuracy. This allows us to create smart loyalty programs based on precise patterns of spend propensity. The bidding of offers is based on profiling and targeting resulting from customer payment flow analysis at both the bank level and external partners (merchants, third-party solutions).Profiling is done on the basis of big data principles through machine learning algorithms and non-linear classifiers. The first commercial partnerships have been finalized to allow speed, critical mass of customers, users and partners in order to legitimize the offer in a very competitive market in terms of marketing and loyalty solution.We have validated our model, developing a profiling and decision-making engine for merchant based on machine learning, and we prepared us for scaling. We have built our tech platform and we are now ready to take off through the consolidation of stakeholders.We are currently deploying our solution with a major bank (BNP Paribas) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular mechanism of macrolide antibiotic action and resistance: application in drug development' (MOL-MECH-MAC).

assistant: **Innovation**

the present number one threat to human health is recognized as being the previously unseen levels of multiple antibiotic resistances that exist in bacterial pathogens. The development of new antibiotics is of crucial importance. Unfortunately, the mechanism of action of commonly used antibiotics is not fully understood. Understanding the molecular mechanisms of antibiotic action and resistance will make the rational design of new drugs possible. We aim to elucidate the structural origins for the action and resistance of a class of antibiotics, the macrolides.They interact with the RNA component of ribosomes and inhibit protein synthesis. The latest generation of macro ides, the deltoids, exhibit high activity againstmacrolides-resistant bacterial strains . A combination of genetic , biochemical and structural tools originating from different groups will be use used. Structural data will be essential for the development of new therapeutic agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CO2-based Electrosynthesis of ethylene oXIDE' under Horizon 2020.

assistant: **Concept**

The CO2EXIDE project aims at the development of a combined electrochemical-chemical technology for the simultaneous “200%” conversion of CO2 to ethylene at the cathode, water oxidation to hydrogen peroxide at the anode and a subsequent chemical conversion of both intermediates to ethylene oxide and oligo-/polyethylene glycol in a cascade, boosting this technology from TRL4 to TRL6. The CO2EXIDE technology combines a modular nature for the feasibility of a decentralised application, a high energy and material efficieny/yield and the substitution of fossil based production of ethylene oxide. The CO2EXIDE technology will be combinable with renewables and allows for the direct creation of products, which can be integrated into the existing supply chain. The reactions will be operated at low temperatures and pressures and forecast significant improvements in energy and resource efficiency combined with an enormous reduction of GHG emissions. All improvements will be quantitated using Life Cycle Assessment. The CO2EXIDE approach will bring together physicists, chemists, engineers and dissemination and exploitation experts from 5 universities/research institutions, 3 SMEs and 2 industries, innovatively joining their key technologies to develop and exploit an unprecedented process based on CO2, renewable energy and water to combine the chemical and energy sector.Within 42 months project duration, the CO2EXIDE technology will undergo a thorough material and component R&D programme. A 1kW PEM electrolyser for CO2-reduction and water oxidation in combination with an ethylene enrichment unit and subsequent chemical conversion cascade reactor will be manufactured to produce ethylene oxide as intermediate for oligo-/polyethylene glycol synthesis. This will prove the achievement of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of New Instruction and Evaluation Methods for the Utili sation of Modern Pressure Measuring Systems to Support Diabetics with Better Ort hopaedic Footwear' in the context of a Fourth Framework call.

assistant: **Objectives**

In the past, the treatment of diabetic patients was based solely on the subjective experience of the individual orthopaedic shoe technician. Patients suffering from neuropathy are unable to inform the orthopaedic shoe technician about the correctness of the treatment. For this reason, the orthopaedic shoe technicians have to control the treatment for the patients in shortterm intervals to conduct necessary corrections before the feet will be affected. The expenses for these follow-up corrections have to be borne by the companies. By means of the pressure measuring systems developed in the recent years, the orthopaedic shoe technicians, for the first time, have the opportunity to control the quality of their work irnmediately during the application of the orthoses to the foot. Scientific fundaments for the interpretation of measurement values and their practical transformation into orthopaedic shoe technical measures are missing for the application of modern measuring systems. With this project, the technological fundamentals for this task are to be acquired. The results achieved are to be comprised in software for the evaluation of the measuring of the pressure distribution. With these technological fundamentals, it will be possible to drastically reduce the time consumption for the follow-up work on the evaluation of orthoses and, thereby, substantially reduce the production costs. Through this improved treatment for the patients, the amputation rate due to severe foot problems can be reduced. The mobility of the patients is retained for a longer period, thereby contributing to an improved quality of life.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Gender inequalities in the home: Social structures, identities, and the division of family labor'.

assistant: **Concept**

The proposed study draws on Identity Theory (Stryker, 1980, 2008) to explore gender inequalities in the division of household labor. To overcome existing disciplinary divides, it provides a conceptual and empirical formulation of identities as a route through which the sociological and psychological traditions can be connected. Shifting the focus from the surface level of belief-systems to the deeper meanings individuals apply to the self in a social role, this research advances the claim that identities are shaped, in part, by one’s location in the social structure, and that these identities have consequences for the division of family labor. Although the influence of social structures on identities is a basic premise of identity theory, there is no empirical evidence bearing on this assumption to date. Furthermore, in line with the identity-behavior link delineated by the theory, the salience of spouses’ role-identities should account for their behavioral choices regarding the allocation of responsibilities and time investment in work and family labor. Identities are therefore hypothesized to play a mediating role in the relationships between sociodemographic backgrounds and the division of labor. These hypotheses will be examined in a parallel mixed-methods design. A sample of 150 couples (n = 300) will complete extensive questionnaires. Novel instruments will be developed to address deficiencies in previous measurement of identities. Complementary in-depth interviews will be conducted with 20 of the couples (n = 40). The findings from the quantitative and qualitative data sets will be integrated to provide a deeper and more comprehensive understanding of the mechanisms underlying the division of family labor. By overcoming disciplinary and methodological divides, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Kon-Tiki gene network for CNS regeneration' to be submitted under Seventh Framework.

assistant: **Abstract**

Regeneration after injury occurs in many animals, revealing that cellular and molecular mechanisms regulate normal organ structure, size and shape. The human central nervous system (CNS) does not regenerate upon damage and as a consequence stroke, spinal cord injury, multiple sclerosis and neurodegenerative diseases result in permanent disability. NG2 cells are repair cells in mammals that respond to CNS injury by proliferating to produce ensheathing glia and trophic factors that favor axonal growth. A promising approach to CNS repair is to transplant NG2+ glial progenitors or stem cells to the site of damage. However, it is unknown how to control the proliferation and differentiation of transplanted cells, to ensure repair and prevent unwanted outcomes (e.g. cancer).The glial regenerative response is found across the animals, from cockroaches and flies, to fish and mice, implying that there is an underlying genetic mechanism that has been evolutionarily conserved. Drosophila is a powerful model organism to discover gene networks and test gene function in vivo, and has recurrently led to discoveries relevant to human health. The Host laboratory recently discovered a gene network in Drosophila that can be manipulated in glia to promote CNS repair and the Researcher extended the injury method to enable the assessment of locomotion recovery. There is a Drosophila homologue of NG2 called kon-tiki (kon), but whether it has functions in repair and whether it is functionally linked to the regnerative gene network is unknown.The aim is to investigate the functions of kon in the glial regenerative response in Drosophila. The objectives are: (1) To characterise the cells expressing kon, test whether Kon is linked to Pros and/or Notch, and investigate its functions in the normal C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineering antibodies in B cells using endogenous AID activity' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The AutoEngineering project aims to develop an innovative strategy for B cell engineering by exploiting natural DNA breaks to generate antibodies that surpass common reactivity profiles. The project is based on our surprising finding that in B cells endogenous AID (activation-induced cytidine deaminase) activity can lead to the insertion of a pathogen receptor resulting in broadly reactive antibodies. To unravel this new mechanism of diversification, my laboratory established and developed new methodologies to identify insert-containing antibodies in genomic DNA, mRNA, proteins and cells. We found that insertions in antibody transcripts derive from distant genes, occur across individuals and are inducible in vitro, and we have preliminary evidence that in vitro activation of AID enables integration of a nucleofected DNA substrate. Avoiding exogenous nucleases, this project aims at developing efficient and safe engineering of B cells to produce antibodies by design. Aim 1. By screening for genomic insertions in antibody genes of healthy donors, DNA-repair deficient patients, and manipulated in vitro B cell cultures, we will gain insights into the mechanism of insertion and define biomarkers of DNA repair. Aim 2. The knowledge gained will be used to optimize substrate design and insert integration, while minimizing the potential for off-target integration. We will also explore the possibility to guide AID to target sites using RNAs, and design substrates that allow efficient splicing of an inserted exon. Aim 3. To gain breadth on pathogen recognition and to circumvent the limitation of the heterodimeric antibody binding site, we will use the above approach to engineer B cells to produce antibodies containing receptors for HIV (CD4) and HCV (CD81). Insertion of slim recept