RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural basis of mitochondrial inner membrane shape and dynamic' in the context of a Seventh Framework call.

assistant: **Objectives**

Here, I propose to study the structure and mechanisms of the cellular machineries mediating the shape and dynamics of the mitochondrial inner membrane (IM). The mitochondrial IM contains membrane invaginations called cristae. These are connected by tubular openings, the crista junctions, to the remaining IM. Mitochondrial shape constantly changes due to membrane fission and fusion events, and a balance of both processes is required for proper functioning of mitochondria. Abnormal mitochondrial shape and altered dynamics are associated with severe diseases, such as cancer and neurodegeneration.Sourcing my group’s expertise in dynamin superfamily GTPases, I wish to understand the molecular mechanisms of how OPA1 can achieve mitochondrial IM fusion and cristae formation. To this end, the X-ray crystallographic structure of OPA1 will be determined and complemented by a comprehensive biochemical characterization. Cell-based assays will be employed to decipher the exact mechanism by which OPA1 carries out its two functions and how specific mutations in OPA1 disturb these processes and, thereby, induce human disease.The multiprotein MINOS complex was recently shown to be involved in the formation of crista junctions. I propose to explore the architecture of the MINOS complex. To this end, X-ray crystallographic structures of single components, subcomplexes and, eventually, the complete complex will be determined. Based on these structures, the mechanism of MINOS in mitochondrial membrane remodeling and crista junction formation will be dissected using a structure-based mutagenesis approach.Components of MINOS were shown to interact with OPA1 and with the sorting and assembly machinery (SAM) of the outer mitochondrial membrane. The interactions of MINOS with OPA1 and SAM will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of ryanodine cluster morphology in arrhythmogenic calcium release after myocardial infarction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Contraction of the heart occurs by the intracellular release of calcium  through channels called ryanodine receptors (RyR), after electrical activation. Due to the progression of heart disease, structural and functional remodeling of at the level of the cardiac cell is known to occur. This remodeling process alters the electrical properties of the heart muscle cell and can lead to the production of an irregularity in the electrical activity of the heart called an arrhythmia. Studies have shown a that disruption of the normal behavior of the RyR can lead to the production of arrhythmic events and these have been linked to the occurrence of intracellular waves of propagating calcium release called calcium waves. The precise mechanisms which underlie this process are currently unknown and warrant further investigation. Using a multidisciplinary approach, alterations in RyR cluster structure will be assessed and correlated with alterations in calcium release after remodeling in a rabbit model of myocardial infarction. Using cultured rabbit myocytes, the involvement of a protein called junctophilin-2 in the regulation of the RyR clustering process will also be assessed. The functional consequences of RyR cluster morphological alteration will be assessed, such as phosphyorylation and the efficacy of anti-arrhythmic drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable development Transition through Regulation-Induced technological Change' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The transition toward a sustainable economy has become an urgency rather than just a challenge. Rising to it demands a deep reconsideration of the economic, social and environmental dimensions of development. The rapid degradation of the environment requires a swift and deep transformation. Our diverse team of researchers experienced in different, yet complementary disciplines, aims to provide rigorous scientific evidence on how regulation induces sustainable technological change? We build on expertise in economics, statistical modelling, computer programming and environmental law, and apply cutting-edge methods that have yet to be used to answer this important question. The Porter hypothesis claims, with mixed evidence, that environmental regulation may result in a win-win for the regulated firms through innovation offsets. By contrast, the regulation-induced technological change model we develop posits that stringent regulation will stimulate entry of new players. These are more likely to rise to the challenge with disruptive innovations, instead of incremental improvements by incumbent firms (Schumpeter’s creative destruction). We use the case of the Zero Emission Vehicle (ZEV) program as an instance of regulatory shocks that are stringent enough to be qualified of technology forcing. We begin by calibrating a micro-founded model of regulation-induced technological change. We then investigate empirically the impact of the regulatory shocks on the economy by analyzing innovation and competitiveness; on workers by analyzing the effect of environmental policy stringency on labor skills; and on the environment by analyzing the effect of regulation on air quality. STRICt will thus deliver a comprehensive analysis of the impact of regulation-induced technological change on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spectral methods for evolution equations' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The Functional Analysis Group (Arbeitsgemeinschaft Funktionalanalysis - AGFA) at the University of Tübingen invites applications for postgraduate fellowships at the Marie Curie Training Site Tübingen (Spectral Methods for Evolution Equations: TULKA - TUE). AGFA is a very active research group working primarily on semi group methods for evolution equations, with a strong focus on spectral methods and positivity. Computer simulation and visualization are a special feature of the present program. Fellows will be part of this research group and will profit from a close cooperation with the functional analysis groups at the Universities of Ulm and Karlsruhe .The common activities of these groups were established in 1996 under the name of TULKA (see http://giotto.mathematik.uni-tuebingen.de/tulka.shtml) and have since developed into a well-organized research network on evolution equations. The University of Tübingen was founded in 1477 - among those who studied or taught here over the past 500 years are Schelling, Hegel, Hoelderlin, Bloch, Kepler, Melanchthon, Geiger, Alzheimer. Tübingen itself is more than thousand years old. It lies on the riverside of the Neckar, fifty km south of Stuttgart, and has 80,000 inhabitants. A candidate must be a citizen of the EU (or an associated State) other than Germany, and must be registered as a Ph.D. student in an EU country (or in any associated State) other than Germany. Fellowships can only be awarded for a period between 3 months and 1 year. Applications, including a Curriculum Vitae, a list of publications and a letter of reference, should be sent to: Prof. Dr. Rainer Nagel Mathematisches Institut Universität Tübingen D-72070 Tübingen Germany (email: rana@giotto.mathematik.uni-tuebingen.de)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of Metastatic Organ-on-a-Chip for modelling the role of sex steroids in Bladder cancer metastasis to bone' under Horizon Europe.

assistant: **Concept**

Bladder cancer (BCa) is the 5th most common cancer in Europe, with an annual economic burden of €5 billion. Despite efforts aimed at early detection and targeted therapies, the development of metastatic BCa (5%) remains a major cause of mortality (patient survival rate of only 21 %). Recent evidence has strongly implicated a role of Bone Morphogenic Proteins (BMPs) in BCa progression. However, their regulation remains poorly understood and their role in metastatic BCa remains to be elucidated. Moreover, there is paucity of understanding regarding the gender disparity in BCa, whereby men are 4 times more likely to be diagnosed, compared to women, who have worse prognosis.DeMOBilise seeks to address this critical gap in the knowledge by investigating the synergistic role of sex steroids (SS) and BMPs in BCa bone metastasis. This will be achieved by using single cell multiomics and CRISPR gene editing, coupled with state-of-the-art Organ-on-a-chip (OoC) technology and spatially resolved imaging of the bone perivascular niche within the OoC. This study will thereby investigate, at an unprecedented level of detail, the functional role of BMP signalling and its synergy with SS in BCa metastatic processes.I will spend 2 years at Columbia University (USA) expanding my skills in cancer models and single cell sequencing and also acquiring a new skillset in OoC fabrication. I will return to the University of Limerick (Ireland) and receive training in steroidogenesis, high-dimensional imaging and mass spectrometry. Additionally, I will have a 6-month Non-Academic Placement in the start-up company Hooke Bio, who specialize in the development and utilisation of high through-put microfluidic systems for 3D microtissue drug screening. I will be immersed within a multidisciplinary team
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nano-Magnetic Oscillators' in the context of a Horizon 2020 call.

assistant: **Objectives**

The isolation of graphene sheets ushered the age of 2D materials as the poster children of condensed matter physics. Until a few years ago, 2D magnetism was thought to be impossible to observe experimentally, as any amount of thermal fluctuations is enough to disturb the magnetic order. Recently, the existence of 2D magnets have been proved and these materials have garnered a great amount of interest, both due to their novel physics and to the possibility of downscaling magnetic devices, enabling future beyond CMOS technology. However, the physics underlying 2D magnetism are not fully understood. In this project, we aim to study how the magnetism of 2D monolayers of CrI3 and CrBr3 is modified by applying a mechanical strain, which tunes their intralayer magnetic exchange and ultimately their magnetic order. CrI3 and CrBr3 bilayers will also be used to study the dependence of the magnetic coupling between different layers in van der Waals heterostructures, describing the origin of their interlayer magnetic orderings. Using the same materials, we will fabricate nanomechanical resonators which will be used to study the backaction of magnetic field on oscillating 2D magnets. Ultimately, this project will shed light on how magnetism and mechanics interplay in 2D materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The synthesis and characterisation of cluster star, ribbon and sheet porphyrazine polymers'.

assistant: **Innovation**

Research objectives and content The development of a new system of porphyrazine-based polynucleating ligands that are capable of binding one metal ion at the center and one, two, three or four additional metal ions at the periphery is described. This ligands will be converted into multimetallic, multimacrocyclic arrays, containing star, solitaire and Gemini porphyrazine units, by complexation of one metal ion within each macrocyclic cavity and additional metal ions to the peripheral amine and/or thiolate functionality. In this way multimetallic units will be assembled into supra-order poly-macrocyclic arrays of predetermined structures via link up in a process of controlled oligomerisation. By appropriate choice of the metals, by changes in the coordination sphere of the peripheral metal and by variation in the .inert substituent of the porphyrazine moieties should be possible to prepare an extraordinarily broad range of novel coordination complexes and derived materials superior to existing porphyrazine and phthalocyanine polymers. Training content (objective, benefit and expected impact) With the combination of our different experimental expertise in this field, significant further progress will be made in this important area. The resultant polymers have many industrial applications as novel magnetic, optical, and imaging materials, high performance inks and dyes, in high performance membrane technology, as infrared absorbers, oxidation catalysts, organic photoconductors and sensors... Links with industry / industrial relevance (22) "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Turn-key modular aluminium smelter for a Zero Emission Production Process'.

assistant: **Concept**

Aluminium production is the most carbon intensive process in metallurgy with significant volume of carbon emissions around the world. Arctus Metals Ltd. (AM) developed a turn-key modular aluminium smelter based on an innovative chemical process, which is carbon free, consumes less energy and is much cheaper. The proprietary technology is based on the Beck electrolysis cell exploiting vertical inert electrodes at a lower 750C temperature. The European aluminium smelting industry has been affected by the EU strict environmental policy. AM will offer EU aluminium product manufacturers a solution to reduce/stop aluminium import dependency, currently set high, and regain competitiveness through considerable cost savings. The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and a plan of all activities for industrialization and deployment of the pilots with scaled up smelters. Aluminium manufacturers and potential distrubutors will be contacted and commercial agreements evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Engineering Exotic Phenomena at Oxide Interfaces' to be submitted under Seventh Framework.

assistant: **Abstract**

Emergent phenomena at oxide interfaces have been recognized as one of 2007’s top ten breakthroughs, exciting great interest. Just as the engineering of physical properties at semiconductor interfaces was the crucial step in Si-based electronics, the next great advance might rely on the multiple novel functionalities of oxide interfaces. The consortium OxIDES will (i) develop theoretical and simulation techniques to model the most relevant types of oxide interfaces and (ii) use them to design a new generation of layered materials with unique experimentally-confirmed properties. The theoretical work will combine first and second principles methods in a multi-scale approach. The experimental partners will guide the choice of relevant systems, grow and characterize the most promising structures, and explore their technological applications. This continuous collaboration is essential to guarantee that the theoretical developments are experimentally validated, and is also the most promising avenue towards the discovery of new and technologically important phenomena. In OxIDES we will consider three types of interfaces: insulating interfaces between insulating oxides, where novel couplings between structural instabilities can lead to unusual phenomena such as improper ferroelectricity; conducting interfaces between insulating oxides, where an interfacial 2-dimensional electron gas might exhibit large thermoelectric power; and interfaces between metallic and insulating oxides, for a deeper understanding of screening. All these are potentially interesting for use in microelectronic devices or energy harvesting. Yet, advancing from basic concepts to applications remains a challenge, and both quantum-mechanical simulations and experimental methods need to be developed to tackle it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cost Effective Integral Metallic Structure' in the context of a Sixth Framework call.

assistant: **Objectives**

Friction stir welding (FSW) is now considered mature for simple applications and it has been shown that weight savings of up to 15% and cost savings of 20% can be achieved by its application. As a result FSW will be used in future Airbus aircraft such as A350. All major European airframe manufacturers believe that there are many more applications for FSW in the fabrication of cost effective integral metallic structure. Examples include circumferential joints, tailored blanks, window frames, stringer to skin attachment, spars, enclosed sections and fittings. Major technical advances need to be made beyond the current state of the art for FSW and integral metallic structure to achieve this. It is also necessary for FSW to be able to be applied to new geometries. Therefore the objective for the proposed COINS project is: Extending the application of integral metallic structure utilising friction stir welding by: advancing the state of the art of FSW technology; developing new geometries for FSW; and through innovations in design. To achieve this objective the following activities are planned WP1. Updating process and test standards WP2. Production of integrated design solutions for structure containing FSW, including effects of other manufacturing processes, residual stresses and cracks. WP3. Development of new applications for FSW including new alloys, the use of extrusions/forgings and techniques for applying FSW to new geometries. WP4. Development of in production and in-service repair procedures plus the development of FSW as a repair tool. WP5. Integration of FSW into the whole manufacturing cycle by combining with prefabricated parts and forming techniques, including creep-age forming. WP6. Development of the primary FSW process innovations needed to realise the new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tools for Assessment and Planning of Aquaculture Sustainability' (TAPAS) targeting Horizon 2020.

assistant: **Abstract**

Aquaculture is one of five sectors in the EU's Blue Growth Strategy, aimed at harnessing untapped potential for food production and jobs whilst focusing on environmental sustainability. TAPAS addresses this challenge by supporting member states to establish a coherent and efficient regulatory framework aimed at sustainable growth. TAPAS will use a requirements analysis to evaluate existing regulatory and licensing frameworks across the EU, taking account of the range of production environments and specificities and emerging approaches such as offshore technologies, integrated multi-trophic aquaculture, and integration with other sectors. We will propose new, flexible approaches to open methods of coordination, working to unified, common standards. TAPAS will also evaluate existing tools for economic assessment of aquaculture sustainability affecting sectoral growth. TAPAS will critically evaluate the capabilities and verification level of existing ecosystem planning tools and will develop new approaches for evaluation of carrying capacities, environmental impact and future risk. TAPAS will improve existing and develop new models for far- and near-field environmental assessment providing better monitoring, observation, forecasting and early warning technologies.  The innovative methodologies and components emerging from TAPAS will be integrated in an Aquaculture Sustainability Toolbox complemented by a decision support system to support the development and implementation of coastal and marine spatial planning enabling less costly, more transparent and more efficient licensing. TAPAS partners will collaborate with key industry regulators and certifiers through case studies to ensure the acceptability and utility of project approach and outcomes. Training, dissemination an