RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A novel physiological role for IRE1 and RIDD..., maintaining the balance between tolerance and immunity?' (DCRIDDLE).

assistant: **Innovation**

Dendritic cells (DCs) play a crucial role as gatekeepers of the immune system, coordinating the balance between protective immunity and tolerance to self antigens. What determines the switch between immunogenic versus tolerogenic antigen presentation remains one of the most puzzling questions in immunology. My team recently discovered an unanticipated link between a conserved stress response in the endoplasmic reticulum (ER) and tolerogenic DC maturation, thereby setting the stage for new insights in this fundamental branch in immunology. Specifically, we found that one of the branches of the unfolded protein response (UPR), the IRE1/XBP1 signaling axis, is constitutively active in murine dendritic cells (cDC1s), without any signs of an overt UPR gene signature. Based on preliminary data we hypothesize that IRE1 is activated by apoptotic cell uptake, orchestrating a metabolic response from the ER to ensure tolerogenic antigen presentation. This entirely novel physiological function for IRE1 entails a paradigm shift in the UPR field, as it reveals that IRE1’s functions might stretch far from its well-established function induced by chronic ER stress. The aim of my research program is to establish whether IRE1 in DCs is the hitherto illusive switch between tolerogenic and immunogenic maturation. To this end, we will dissect its function in vivo both in steady-state conditions and in conditions of danger (viral infection models). In line with our data, IRE1 has recently been identified as a candidate gene for autoimmune disease based on Genome Wide Association Studies (GWAS). Therefore, I envisage that my research program will not only have a large impact on the field of DC biology and apoptotic cell clearance, but will also yield new insights in diseases like autoimmunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Eco Friendly Tuneable Microwave continuous Flow Reactor for the Synthesis of Lecucettamines in Therapeutic Activity Against Alzheimer's Disease' (MICRO-THERAPY), addressing dissemination and exploitation.

assistant: **Impact**

The four-year MICRO-THERAPY is a fully integrated interdisciplinary proposal which will develop a new area of competence in the three partners, Liverpool John Moores University, University of Rennes1 and ManRos Therapeutics. It brings together a powerful set of partners covering fully the three key aspects - microwave engineering, chemistry and biology to create new technology and sustainable technical and scientific expertise applicable to the bio-pharmaceutical industry. The proposed research programme is unique in terms of generating a tuneable, multipurpose, microwave, continuous, atmospheric pressure, flow reactor for the efficient conduct of various chemical reactions for the synthesis of Leucettamines to be used against Alzheimer’s disease. Unlike the restricted batch reactors a continuous microwave reactor has the potential to operate at high production rates simply by virtue of offering continuous throughput and, more significantly, by being easy to replicate allowing scale up the process for bulk production at commercial rates. In addition the system will operate for the first time with tuneable frequency microwaves in the range 2.45 – 8GHz in order to optimise the process to produce higher yields with reduced separation costs. This is unlike current microwave synthesis where the source is only operated at one fixed frequency of 2.45GHz and is therefore not necessary have the optimum operating frequency to suit various chemicals reactions at different temperatures. The timeliness of MICRO-THERAPY is a response to demand for new ways to produce chemicals for the therapeutic activities against Alzheimer’s disease. However, such a reactor also has scope fore much wider applicationThe main objectives of this project are to:1. To use the project to develop new cros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Early alarm system for groundwater contamination monitoring' to be submitted under Horizon 2020.

assistant: **Abstract**

EnviroALARM is an eco-innovative online monitoring system specially developed to significantly improve the existing technologies for groundwater (GW) pollution surveillance, contributing to radically reduce the potential environmental impact of contaminant leakages from hydrocarbon and/or chemical storage sites. There are over 1 million sites with high potential to contaminate GW worldwide (petrol stations, refineries, storage centres, etc.). At present, there is not an affordable and reliable system to daily detect hydrocarbon leakages to groundwater.  EnviroALARM fits within the European priorities to prevent and minimize environmental impacts, developing an eco-innovative product to continuously monitor the potential presence of hydrocarbons in the GW. The global environmental monitoring market is poised to grow at a Compound Annual Growth Rate (CAGR) of 7.5% during 2015-2020, and is expected to reach a value of ~$20.5 Billion in 2020.The main advantages of EnviroALARM over current competitors are: i) Daily monitoring, promoting the early detection and hence the measures to mitigate the contamination; ii) High sensitivity to the presence of contaminants, detecting leaks below 0.4 l/h. iii) Reliable without false alarm based on a proprietary sensor technology; iv) Wireless system not requiring civil work installation; v) Significant cost reduction (up to 80%) over current market competitive solutions. EnviroALARM innovative sensor based on a physicochemical reactions is unique in the world. This solution present a huge market opportunity, since it applies to a worldwide problem offering an easily replicable and transferable technology that fulfils the increasing regulations at EU and international level.The main objective of the present proposal is the determination o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The ubiquitin system in RAS-driven disease' (UB-RASDisease).

assistant: **Concept**

The RAS pathway is the most frequently activated signaling node in human disease. Despite intensive efforts, effective therapeutic strategies for RAS-driven disease remain daunting. Elucidation of the mechanisms of RAS activation promises to lead toward novel therapeutic approaches to inhibit RAS activity, and may permit identification of patients who might benefit from RAS pathway inhibitors. Our preliminary studies show that reversible ubiquitylation controls RAS activity by altering its interaction network, thus representing a conceptually novel mechanism of RAS regulation. Our initial steps towards the understanding of the RAS ubiquitylation machinery have shown that positive regulators of RAS ubiquitylation are frequently mutated or down-regulated in RAS-driven diseases, whereas negative regulators are commonly up-regulated. These striking initial results suggest that dysregulation of RAS ubiquitylation may be an alternative mechanism that drives RAS activation in human disease.Here, we aim to elucidate the role of the ubiquitin system in RAS-driven disease. We will unravel the molecular machinery controlling RAS ubiquitylation and ascertain alterations of the identified machinery in RAS-driven disease. To assess the functional impact of these alterations, we will create genetically modified mouse models and CRISPR-engineered human cell models. We will employ cutting-edge proteomic approaches to determine how disease-associated dysregulation of RAS ubiquitylation perturbs RAS interactions and signalling. Using a synthetic biologic approach, we will obtain insights into mechanisms by which ubiquitylation modulates RAS interactions. It is significant that, in contrast to the majority of known RAS regulators, the ubiquitin enzymes are “druggable”, which implicates the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DIFFERENT (DIgital beam Forming For low-cost multi-static spacE-boRnE syNthetic aperTure radars)' to be submitted under Seventh Framework.

assistant: **Abstract**

DIFFERENT aims at building the foundation of a new generation of space-borne Synthetic Aperture Radars (SAR) with a significant reduction in cost, size, mass and power consumption, and enhanced performances with respect to systems currently available.  The final product will be a compact, dual-band, dual-polarization radar with DBF capabilities. DIFFERENT will achieve these results setting up a consortium between SMEs and research institutions to develop and to exchange technologies and know how to improve competitiveness of SMEs. 1) DIFFERENT proposes advances towards space-borne radars building a low-cost, compact SAR by combininga) a new concept of multi-static dual-band (Ka/X) dual-polarization passive SAR having digital beamforming (DBF);b) the development of DBF BICMOS chip and of SiGe MMIC to enhance radar operations and to allow an unprecedented level of integration; c) the development of a dual-band (Ka/X) dual-polarized low-cost array antenna which will have a shared apertur; d) integration technologies that will make use of materials new to the space sector and that will ensure the high level of integration to reduce costs and weight of the overall payload. 2) DIFFERENT targets the stable integration of SMEs into the Earth Observation (EO) value chain by developing know how in the following key areas which are recognized as strategic for the future scientific and commercial missions a. SiGe BiCMOS integrated circuitsb. Advanced integration techniquesc. Digital Beam Forming3) DIFFERENT will open to SMEs new possibilities in the entire space sector developing a distributed SAR space system fulfilling governmental and commercial needs. 4) The DIFFERENT consortium is tailored to sustain the involved SMEs towards the acquisition of a leading role in the EO value c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Emission controll system for wastewater treatment'.

assistant: **Innovation**

Wastewater treatment plants are major contributors of greenhouse gasses emission and responsible for 1-2% of emissions worldwide. VARIO emission control is the first system that enables online monitoring of greenhouse gases (nitrous oxide and methane) and chemical pollutants in wastewater treatments plants. The VARIO solution measures relevant substances automatically and adjusts the wastewater plants aeration system via AI models. The technology combines sensorics (mass spectrometry) and data driven models (AI), for adjusting wastewater treatment process parameters. It does this in multiple aeration basins with one analyzer via its multiplexing capabilities to save costs for operators. By using VARIO the benefits for wastewater treatment plants are: 20% costs saving for energy and chemical consumption, as well as a tremendous reduction of emissions by up to 50%. For society, these savings are equivalent to millions of vehicles off the street or a 25% reduction in airline travel.


**Keywords:** greenhouse gas reduction,direct emission,Industrial bioengineering,Environmental protection,Energy management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Forced displacement and refugee-host community solidarity' (FOCUS).

assistant: **Concept**

In 2015 and 2016, the EU experienced an unparalleled influx refugees and migrants. This situation poses multiple challenges for social- and health services and labour markets in host communities as well as for the lives of the refugees. In response to this situation, the vision of FOCUS is to increase understanding of, and provide effective and evidence-based solutions for, the challenges of forced migration within host communities and thereby contribute to increased tolerance, peaceful coexistence, and reduced radicalization across Europe and in the Middle East. Based on a comprehensive mapping and trans-disciplinary, multi-site field research conducted in Jordan, Croatia, Germany and Sweden, FOCUS explores the socio-psychological dimensions of refugee- and host-community relations and analyses the socio-economic integration of refugees and the consequences of this in host societies. The research sites have been selected to ensure that insights and lessons are derived from medium- and long-term experiences with forced displacement and local integration.This knowledge is used to transform and strengthen existing promising solutions for social- and labour market integration. The integration solutions will be pilot tested in at least five European countries by governmental and non-governmental end-users. The solutions are finally brought together in the Refugee and Host Community Toolbox, which will support policy makers, municipal actors, civil society organisations and other stakeholders in responding to the needs of both refugees and host communities and thereby act as agents of change in this field.In addition, FOCUS undertakes an ambitious programme of engagement with policy makers, end-users, host communities, refugees and other stakeholders. This will ensure that F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The molecular complexity of the complement system' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The complement system is a regulatory pathway in mammalian plasma that enables the host to recognize and clear invading pathogens and altered host cells, while protecting healthy host tissue. This regulatory system consists of ~30 large multi-domain plasma and cell-surface proteins, that act in concert through an interplay of proteolysis and complex formations on target membranes. We study the molecular events on membranes that ensure initiation and amplification of the response, protection of host cells and activation of immune responses leading to cell lysis, phagocytosis and B-cell stimulation.In the past few years, we have resolved the structural details of the large complement proteins involved in the central, aspecific labelling and amplification step; with recent data we revealed the structural basis of the assembly and activity of the protease complex associated with this step. These insights into the central aspecific reaction, and the experiences gained on working with these large multi-domain proteins and complexes, give us an excellent starting point to addres the questions of specificity, protection and activation of immune cells.The goal of the proposal is to elucidate the multivalent molecular mechanisms of recognition, regulation and immune cell activation of the complement system on target membranes. We will use protein crystallography and electron microscopy to study the interactions and conformational changes involved in protein complex formation, and (single-molecule) fluorescence to resolve the multivalent molecular events, the conformational states and transitions that occur on the membrane. The combined data will provide mechanistic insights into the specifity of immune clearance by the complement system.Understanding the molecular mechanisms of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Next generation urban mining - Automated disassembly, separation and recovery of valuable materials from electronic equipment' (ADIR) under Horizon 2020.

assistant: **Objectives**

Specific raw materials become increasingly important to manufacture high level industrial products. Especially electronic equipment contains precious metals and a series of strategic raw materials. To date the material specific recycling is focused on mass stream concepts such as shredder processes and metallurgy to extract the high-value metallic constituents, i.e. copper, gold, silver. However, a series of critical elements cannot be recovered efficiently or is even lost in dust or residual fractions. The goal of ADIR is to demonstrate the feasibility of a key technology for next generation urban mining. An automated disassembly of electronic equipment will be worked out to separate and recover valuable materials. The concept is based on image processing, robotic handling, pulsed power technology, 3D laser measurement, real-time laser material identification (to detect materials), laser processing (to access components, to selectively unsolder these; to cut off parts of a printed circuit board),  and automatic separation into different sorting fractions. A machine concept will be worked out being capable to selectively disassemble printed circuit boards and mobile phones with short cycle times to gain sorting fractions containing high amounts of valuable materials. Examples are those materials with high economic importance and significant supply risk such as tantalum, rare earth elements, germanium, cobalt, palladium, gallium and tungsten.A demonstrator will be developed and evaluated in field tests at a recycling company. The obtained sorting fractions will be studied with respect to their further processing and recovery potential for raw materials. Refining companies will define requirements and test the processing of sorting fractions with specific material enrichm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Optical fiber higher order mode technologies and their application within communication, sensing and bio imaging'.

assistant: **Concept**

Optical fibres supporting propagation of light in so-called higher order modes (HOMs) have gained major research interest in the last years. However, there are still quite a few obstacles to overcome before HOM fibres can be used for major commercial applications. In the HOMTech doctoral network, seven leading European universities, within the field of HOM fibres and their applications, join forces with one research institution and three European industrial partners and two world leading industrial research labs in the USA and Japan with the aim to significantly progress the field of HOM fibres and their applications. Five European countries are represented. Ten doctoral candidates (DC) will work in the network. Apart from the research and training at the host beneficiary, each DCs will also have two research secondments (both at least 3 months long) at another beneficiary or an associated partner. For DCs from academic partners, at least one of the secondments will be to an industrial partner. Five training schools in five different countries will be organized for the DCs through a joint effort between all beneficiaries.The research is organized in three work packages (WPs). WP1 on HOM applications within communication (both in optical fibres and in free space), WP2 on properties of HOMs, and WP3 on HOM applications within sensing. WP2 act both as support for WP1 and WP3, e.g., WP2 research essential non-linear properties of HOM fibres that is key in optical communication, but also applications of HOM for microscopy imaging. In WP1 both classical communication as well as quantum communication will be researched.It is the ambition that HOMTech will build a strong and lasting network not only between the DCs but also between the beneficiaries and associated partners. HOM