RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure-function mapping of the nuclear receptor coactivator tif2 and identification of downstream targets' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Multiple aspects of growth, development, as well as homeostasis in higher eukaryotes are regulated by ligand-inducible nuclear receptors (NRs), but the mechanisms through which these transcription factors act on basal transcriptional machinery remain largely elusive. Squelching" observations led to the prediction of NR-associated transcriptional intermediary factors (TIFs, coactivators, corepressors). Amongst recently identified candidate TIFs, only TIF2 and the related SRC-1 proteins possess all the expected characteristics of a TIF. The proposed project intends to unravel the chain of events by which TIF2 transmits signals to the basal machinery. This involves a three-step strategy: (i) Establishment of a TIF2 functional-domain map to identify an activation-function-conferring fragment (AF) to be used as screening probe. (ii) Expression library screening to clone TIF2 AF-interacting "downstream" factors and additional factors interacting with the TIF2 PAS domain (a possible dimerization function predicted from sequence homology). (iii) Scrutiny of positive clones to track protein-protein interfaces and assess their role in transactivation or in the "cross-talk" with the API complex. Training content (objective, benefit and expected impact) Beyond offering the opportunity to become familiar with a number of important methodologies including expression screening and transactivation studies, this project set in the challenging international climate of the IGBMC Strasbourg will particularly strengthen my scientific working skills and help to extend my expertise in the transcription regulation and hormone receptor fields, thus preparing me for future independent research work. Links with industry / industrial relevance (22) A deepened unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Parameterised Families of Strange Attractors described through Inverse Limits' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This project aims to study topological and dynamical aspects of two dimensional paradigm of chaos called Hénon attractors and introduce new treatable parametrised family of strange attractors appearing in smooth dynamical systems.  Despite Hénon attractors have been known to mathematicians for more than 40 years, the topology of the attractors has not been studied in details yet. The main obstacle that such a study has not been established was the lack of techniques necessary to perform it. Building on recent advances in describing parametrised families of strange attractors using inverse limits we will delve in such a detailed study and give new results on topological, dynamical and measure-theoretic features appearing in parametrised families of strange attractors. We will use methods and techniques from Topological, Smooth, Surface and Symbolic Dynamics as well as Continuum and Ergodic Theory.


**Keywords:** Topological Dynamical Systems, Strange Attractors, Parameterised Families of Functions, Inverse Limits, Inhomogeneities, Hénon attractors, Standard Family of Circle Maps
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhancing biological drug production through protein secretion' in the context of a Horizon 2020 call.

assistant: **Objectives**

Biotherapeutics are bio-materials, which are used among others to treat cancer, diabetes, and rare diseases. It is expected that these medicines will make up half of the medicines in future. Already now, 350 million patients are treated with biotherapeutics, produced from proteins. The proteins that are injected to humans must be “clean” and pure. However, harvesting a protein from cells and purifying it is a daunting challenge. Current harvesting methods are complicated and expensive.We made a discovery, which would significantly improve the harvesting and purification process, therefore lowering drug production costs. In this process, biological cells are producing desired proteins from a gene that was planted into the cell’s genome. The key is that after the protein has been produced within cells, we will then induce the cells to send the protein outside – to the liquid medium. This makes the harvesting and purification process much more efficient. The innovation lies in encoding the protein with RNA-based tag. When attached to a gene of interest, the tag will make the producing cell secrete the encoded protein to the medium.If we program proteins to be secreted to the extracellular medium more efficiently protein harvesting and purification process in Pharma, Biotech and Agricultural industries could be revolutionized. This is extremely important for the Pharma industry, which is struggling on low return on investment, already threatening the sector’s viability. Quicker drug development process, cheaper and higher quality production and improved ROI will create also societal benefit. In the end, new drugs can be discovered and brought to markets quicker. In the PoC, we will characterize and discover the best tags for protein production and secretion and use it to se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nutritious, safe and sustainable seafood for consumers of tomorrow'.

assistant: **Innovation**

SEAFOODTOMORROW aims to validate and optimize commercial solutions for improving the socioeconomic and environmental sustainability of the seafood production and processing industry, while contributing to product quality and safety. Activities will focus on the sustainable production and processing of nutritious and safe seafood products through the demonstration and first application in the market of eco-innovative, sustainable solutions of marine and aquaculture-derived food products and nutrients. The proposal will take into account impacts across different regions and population segments, as well as the specificities of different types of seafood.Activities will include among others: utilization of agro and seafood byproducts to develop sustainable feeds for aquaculture enabling the production of tailor made products fortified with specific essential nutrients for consumers, assess the feasibility of salt replacers in seafood, validate digestible, attractive, functional and nutritionally adapted seafood for senior people and youths, validate strategies to prevent/remove contaminants from seafood, and optimize sensors and biosensors for the assessment of safety, among others.The consortium expects strengthening the wider utilization of eco-innovative solutions, as a result of greater user acceptance, higher visibility of these innovative solutions and creation of scalable markets, and increasing the availability of healthier seafood to improve consumers' diet and health. The consortium is built on interdisciplinary research teams of 19 RTDs involved, renowned by its top-quality applied technological development and with strong and cohesive links gathered in previous funded activities (e.g. FP7 ECsafeSEAFOOD), thus anticipating successful outcomes. In addition, 4 IAGs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Calcineurin isoforms in cardiac disease and regeneration' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Heart failure is one of the leading causes of human death. The limited capacity for cardiac self-repair after muscle cell death is one of the elemental challenges in human heart disease. Calcineurin (Cn) is a calcium-regulated Serine/Threonine phosphatase involved in a wide variety of biological processes, including heart development, neuronal plasticity and lymphocyte activation.We have recently demonstrated that expression of a naturally occurring splicing variant of the Cn catalytic subunit (termed CnAb eta1) is able to enhance skeletal muscle regeneration, reducing scar formation and inflammation.We hypothesize that CnAbeta1 expression in adult heart results in enhanced cardiac healing capacity and propose the following research aims:- To analyse of t he expression of the different CnA isoforms in human and mouse models of cardiac failure and regeneration- To analyse of the effect of expressing CnAbeta1 and its alternative splicing variant CnAbeta2 in the heart- To study the capacity of CnAbeta1 to enhance cardiac regeneration- To identify the signalling mechanisms triggered by CnAbeta1 Myocardial over-expression of CnAbeta1 and CnAbeta2 will be examined using a cardiac-specific transgenic mouse model and by cell-based delivery methods.Effects of C nAbeta1 on cardiac regeneration will be analysed in myocardial infarction and generalised heart failure models. The results obtained will provide key information for our understanding of the mechanisms underlying cardiac regeneration and calcineurin regulation and function, increasing the European knowledge base.Moreover, the proposed project will evaluate the potential of CnAbeta1 as a therapeutic agent for the treatment of heart failure, allowing the generation of new clinical protocols and drugs based o n the use of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of immune cells in Alzheimer's disease' under Horizon 2020.

assistant: **Concept**

Alzheimer’s disease is the most common form of dementia affecting more than 35 million people worldwide and its prevalence is projected to nearly double every 20 years with tremendous social and economical impact on the society. There is no cure for Alzheimer's disease and current drugs only temporarily improve disease symptoms. Alzheimer's disease is characterized by a progressive deterioration of cognitive functions, and the neuropathological features include amyloid beta deposition, aggregates of hyperphosphorylated tau protein, and the loss of neurons in the central nervous system (CNS). Research efforts in the past decades have been focused on neurons and other CNS resident cells, but this ""neurocentric"" view has not resulted in disease-modifying therapies. Growing evidence suggests that inflammation mechanisms are involved in Alzheimer's disease and our team has recently shown an unexpected role for neutrophils in Alzheimer's disease, supporting the innovative idea that circulating leukocytes contribute to disease pathogenesis. The main goal of this project is to study the role of immune cells in animal models of Alzheimer's disease focusing on neutrophils and T cells. We will first study leukocyte-endothelial interactions in CNS microcirculation in intravital microscopy experiments. Leukocyte trafficking will be then studied inside the brain parenchyma by using two-photon microscopy, which will allow us to characterize leukocyte dynamic behaviour and the crosstalk between migrating leukocytes and CNS cells. The effect of therapeutic blockade of leukocyte-dependent inflammation mechanisms will be determined in animal models of Alzheimer's disease. Finally, the presence of immune cells will be studied on brain samples from Alzheimer's disease patients. Overall, I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Computational Modelling and Analysis of Automotive Vehicle Body Noise and Vibration' (COMVEBONOV) targeting Seventh Framework.

assistant: **Abstract**

This Marie Curie IAPP involves two partners – the University of Sussex UK, and CDH AG, a German SME employing around 30 people, supplying high-quality computer-aided engineering to the global automotive industry. A 4-year project is proposed involving secondments of both early-stage and experienced researchers. The proposed topic of research is on the probabilistic modelling and analysis of uncertain structures important to vibro-acoustic design of automotive vehicles, aerospace, and marine structures. The research project will attempt to extend a new approach developed by the partners which has been tested in the low-frequency region, but also has the potential to work in the mid- and high-frequency regions, where the SME currently has limited capability. Extensions of the method will provide an excellent training and career development path for researchers who wish to work on uncertain structures across the entire frequency range. Each partner plans to recruit an experienced researcher at respective locations for continuous periods of two years, phased appropriately. This recruitment will hopefully lead to the creation of a more flexible method than currently exists for use in the mid-frequency range, since existing high-frequency approaches are quite difficult to use in the mid-frequency region, and cannot be used in the low-frequency region. A successful outcome to this proposal will: i) give a number of early-stage and experienced researchers exposure to advanced vibro-acoustic analysis methods in both a traditional university setting and a challenging commercial environment, ii) enhance both partner research capabilities in the high-frequency vibro-acoustic region, iii) create a more flexible mid-frequency technique needed by the automotive industry, and iv) enhan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Strategies and Tools to Assess and Implement noise Reducing measures for Railway Systems'.

assistant: **Concept**

STAIRRS proposal is a response to Task 2.2.2/5 in the 5th Framework Programme Sustainable Mobility and Intermodality: Competitive and Sustainable Growth.It contains three work Packages:WP1. Development of a tool for a common European scale cost benefit study of different options for implementing low noise solutions, leading to industrial development and implementation of optimal solutions on a local, national and international level.WP2. Refinement of assessment of noise from railway systems, using advanced procedures to prevent the need to duplicate measurements for interoperable vehicles, and thus reduce testing costs, by providing values applicable to various countries, by a single operation. Such methods will also allow separation of vehicle and track contributions to rolling noise.WP3. Validation to strategy makers using results from WP1 and WP2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'E-Protection of Appliances through Secure and Trusted Access' under Fifth Framework.

assistant: **Concept**

E-PASTA will specify, develop and demonstrate a trust and security platform for extended smart home environments. Such environments will allow applications such as remote control, remote security, or remote maintenance. Two types of connectivity will be assessed: through simple gateways and through services gateways where Java applications can be deployed (e.g. following the Open Services Gateway OSGi initiative). The existing experience available in the smart card industry and other small systems industries, as well as in the Internet will serve as starting point. The resulting technology specification will be promoted for standardization in the home networking and gateway community.Objectives:The objective of e-PASTA is to design, develop and assess a trust and security platform for smart home environments. Such environments will allow applications such as remote control, remote security, or remote maintenance.They consist of:- appliances, which are interconnected through local home control networks;- gateway appliances which connect them to the Internet;- user interfaces such as mobile thin clients (e.g. Wap mobile).From an industrial viewpoint, the objective is to define an architecture for trust and security which:- meets the level of trust and security which future applications will require;- is consistent with international and national regulations;- can be endorsed at the international level, possibly with appropriate variant capabilities;- takes into account different solutions for connectivity such as simple gateways and services gateways;- is scaleable for mass deployment (millions of homes, even more connected appliances);- takes into account the full spectrum of appliances at home including very low-cost appliances with small memory footprint.Work descripti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Relative importance of different enterotoxins in Bacillus cereus food poisoning' in the context of a Fifth Framework call.

assistant: **Objectives**

B. cereus was implicated in diarrhoeal food poisoning by two different multicomponents enterotoxins (HBL, NHE) and by one component enterotoxin (EntK). W e want to find out which of the three enterotoxins is the most involved in food poisoning and which of them is the most active virulence factor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Establishment of Services enhancing the innovation management capacity of SME's through the Enterprise Europe Network Ireland' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Our proposal is aimed at providing specialised services for building innovation management capacities in SMEs as well assupporting SME beneficiaries from H2020 funding through the KAM - Key Account manager - role in overseeing specialistcoaching services after assessment on innovation weaknesses


**Keywords:** Enterprise Europe Network, Ireland Innovation support
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of tuberculosis vaccine with consistent efficacy in differentregions of the world' to be submitted under Fourth Framework.

assistant: **Abstract**

* To construct and investigate the efficacy and mode of action of experimental vaccines in animal models. * To study the interactions between environmental mycobacteria and vaccine induced protection in animal models.Expected OutcomeAn identification and recombinant production of novel immunodominant antigens. An overview of the immunogenicity and protective efficacy of these. An overview of the mycobacterial antigens that are relevant for protective immunity against tuberculosis in humans 2) Investigation of experimental vaccines in animal modelsObjectives * To construct and investigate the efficacy and mode of action of experimental vaccines in animal models. * To study the interactions between environmental mycobacteria and vaccine induced protection in animal models.Activities Production of a fusion protein consisting of ESAT-6 and Ag85B. Testing of the immunogenicity of this hybrid molecule. The level of acquired resistance following immunization with the hybrid in the presence or absence of various cytokines and inhibitors will be studied. The influence of pre-vaccination exposure to environmental mycobacteria on immune responses as well as BCG replication will be monitored and the influence on subsequent protection against tuberculosis evaluated.Expected outcomeCharacterization of the mechanisms underlying the vaccine induced protective immunity. Information on the interaction between immunization and sensitization with environmental mycobacteria.3) Production of ST-CF/DDA vaccine for human useObjectives * To produce and test the new ST-CF/DDA vaccine in humans.Production of an extensive panel of recombinant Culture Filtrate Proteins (CFPs) from cultures of virulent M. tuberculosis. Characterization of the antigens expressed by environmental mycobacteria isolated