RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Generating a 3D Micro necroptosis induced Myocardial Infarction model' (MiniMI) targeting Horizon Europe.

assistant: **Abstract**

Cardiovascular disease remains one of the leading causes of death worldwide, with more than 4 out of 5 of these due to heart attacks. Following a myocardial infarction (MI) the loss of cardiomyocytes (CMs) is irreparable due to their non-proliferative state. Following a MI one of the most promising forms of recovery is using therapeutic drugs. Since generating a new drug requires considerable amounts of money and animal testing there is a need for alternative models such as human induced pluripotent stem cell (hPSC) models. hPSCs provide an excellent platform to model cardiac disease, although 2D models are too immature and currently 3D models are not viable for screening of therapeutic compound libraries. To solve this, I aim to implement a 'kill switch' in a subpopulation of a 3D cardiac tissue, that when triggered will induce necroptosis in the population, simulating a localized heart attack. Integrating macrophages will improve the physiological relevance and cTnT-FUCCI CMs will be used to monitor CM proliferation.To generate this innovative, dependable, inducible model of MI using hiPSCs, the project is divided into 3 achievable goals.1.Generate a hPSC cell line with inducible kill switch system2.Integrate macrophages into microtissues, induce the kill switch, investigate response to localized cell death and cellular changes producing a scRNA-Seq timeline3.Incorporate cTnT-FUCCI cardiomyocytes to investigate cardiac regenerative therapiesI will receive state-of-the-art genetic modification training to generate the cell line (Goal 1), immune cell generation and integration (Goal 2) and bioinformatic study to identify key pathways identified through scRNA-Seq data generated from the MiniMI model to trial cardiac regenerative compounds (Goal 3). This project will not
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards mastering the long-standing challenge of ageing infrastructures in corrosive environments' under Horizon 2020.

assistant: **Concept**

TAMING CORROSION proposes a radically new approach to the long-standing challenge of mitigating corrosion of infrastructures – such as bridges, pipelines, etc. The socio-economic burden of replacing and repairing infrastructures due to corrosion is staggering. In the EU alone, estimates are in the range of 250 billion € annually, with an expected steep increase over the coming decades. This urgently calls for new, cost-effective corrosion mitigation strategies to prolong the useful life of ageing civil infrastructures. Electrochemical corrosion protection (ECP) methods have a large potential to play a key role in addressing this challenge. However, to match these expectations, game-changing advances are needed in both science and engineering. Limited routine use and poor engineering practice of ECP can be traced to insufficient theoretical grounds and a lack of fundamental quantification of key processes. The aim of this proposal is to develop the scientific basis to deliver the first scientifically anchored engineering model and to unlock the potential of ECP as an innovative solution to the grand challenge of rapidly deteriorating infrastructures. The focus areas include: 1) for the first time integrating all relevant physical, chemical, and electrochemical processes into a quantitative model framework for the systematic study of fundamental processes and evaluation of solution strategies. An important novelty lies in combining reactive transport modeling in porous media with rigorous corrosion science. 2) Elucidating the poorly understood role of microbiology in corrosion; and 3) Devising new experiments that link corrosion science and electrochemistry with environmental science methods. Only by delivering ground-breaking scientific contributions will it be possible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bidirectional interactions between cardiomyocytes and cardiac stem cells in the adaptive response to physiological stress'.

assistant: **Objectives**

Stem cell therapy for the treatment of many degenerative and life-threatening diseases has opened up a promising and exciting outlook for the future of medicine and drug therapy. The recent discovery of cardiac stem cells (CSCs) present in the adult mammalian heart, including the human, has stimulated a new and exciting field for cardiac biology. These resident cells express defined stem cell markers (i.e. c-kit), are clonogenic, self-renewing and multipotent. They also have significant regenerative potential when injected into the infarcted rat myocardium. However, despite rapid progress, many questions remain to be answered before the clinical potential of adult cardiac stem cells can be fully realized and exploited. Indeed, identifying factors that regulate cardiac stem cell fate is of great importance to design better protocols and interventions for the regeneration of functional contractile mass following myocardial injury. Recent research by myself and colleagues has identified CSC activation and new myocyte formation as playing a key role in exercise training-induced cardiac physiological remodelling in the mouse. In this project, using a controlled-intensity exercise training model and novel genetic fate mapping of CSCs, I will answer the much debated question of whether CSCs are the direct source of new myocyte formation in the adult mammalian mouse heart. Following this, through gene expression array I will determine whether myocyte-dependent growth factor release drives the exercise training induced cellular adaptation of the heart. Then I will evaluate in vitro the role of these pivotal growth factors in regulating CSC fate. Obtaining this key information on stem cell biology will be useful for manipulating the regenerative potential of these cells and there
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Exploring Relations in Structured Data with Functional Maps'.

assistant: **Concept**

We propose to lay the theoretical foundations and design efficient computational methods for analyzing, quantifying and exploring relations and variability in structured data sets, such as collections of geometric shapes, point clouds, and large networks or graphs, among others. Unlike existing methods that are tied and often limited to the underlying data representation, our goal is to design a unified framework in which variability can be processed in a way that is largely agnostic to the underlying data type. In particular, we propose to depart from the standard representations of objects as collections of primitives, such as points or triangles, and instead to treat them as functional spaces that can be easily manipulated and analyzed. Since real-valued functions can be defined on a wide variety of data representations and as they enjoy a rich algebraic structure, such an approach can provide a completely novel unified framework for representing and processing different types of data. Key to our study will be the exploration of relations and variability between objects, which can be expressed as operators acting on functions and thus treated and analyzed as objects in their own right using the vast number of tools from functional analysis in theory and numerical linear algebra in practice. Such a unified computational framework of variability will enable entirely novel applications including accurate shape matching, efficiently tracking and highlighting most relevant changes in evolving systems, such as dynamic graphs, and analysis of shape collections. Thus, it will permit not only to compare or cluster objects, but also to reveal where and how they are different and what makes instances unique, which can be especially useful in medical imaging applications. Ultima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rationally Designed Aquatic Receptors integrated in label-free biosensor platforms for remote surveillance of toxins and pollutants' under Seventh Framework.

assistant: **Concept**

RADAR is a 7-member consortium that aims to develop a robust, sensitive, and versatile label-free, biosensor platform for spot measurements and on-line monitoring of toxins and pollutants in food production processes and in the aquatic environment.Specificity towards chemical pollutants and toxins is achieved by using recombinant receptors (namely the estrogen receptor and the aryl hydrocarbon receptor) whose amino acid sequences have been rationally designed based on genomic and functional information from aquatic organisms.Sensitivity of the biosensor is increased by the unique combination of isotachophoretic pre-concentration step, and surface nanostructuring & chemical modification.The integration of the label-free detection sensors with an on-line automated sample handling and a wireless communication system will yield a best-in-class biosensor platform for robust, specific and sensitive detection of EDCs and PAHs in difficult operating conditions.To validate the RADAR biosensor the consortium will test the biosensors in fresh and marine water, in fish farms, and in food products such as fish, fruit juices, and milk. Through their contacts in these industries, the partners will evaluate the performance of the biosensors in such environments, analyzing a representative number of samples and reporting on the stability, ruggedness and accuracy of the sensors used under laboratory and real test conditions.This project is expected to have a high economic impact, since our cost-effective sensor could find a worldwide distribution in most food production and water testing lines as supported by Agilent Technologies Inc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Improved Robotic Platform to perform Maintenance and Upgrading Roadworks: The ΗΕRΟΝ Approach'.

assistant: **Innovation**

HERON aims to develop an integrated automated system to perform maintenance and upgrading roadworks, such as sealing cracks, patching potholes, asphalt rejuvenation, autonomous replacement of CUD elements and painting markings, but also supporting the pre/post-intervention phase including visual inspections and dispensing and removing traffic cones in an automated and controlled manner. The HERON system consists of: i) autonomous ground robotic vehicle that will be supported by autonomous drones to coordinate maintenance works and the pre-/post- intervention phase; ii) various robotic equipment, including sensors and actuators (e.g., tools for cut and fill, surface material placement and compaction, modular components installation, laser scanners for 3D mapping) placed on the main vehicle; iii) sensing interface installed both to the robotic platform and to the Road Infrastructures (RI) to allow improved monitoring (situational awareness) of the structural, functional and RI’s and markings’ conditions; iv) the control software that interconnects the sensing interface with the actuating robotic equipment; v) Augmented Reality (AR) visualization tools that enable the robotic system to see in detail surface defects and markings under survey; vi) Artificial Intelligence/AI-based toolkits that will act as the middleware of a twofold role for: a) optimally coordinating the road maintenance/upgrading workflows and b) intelligent processing of distributed data coming from the vehicle and the infrastructure sensors for safe operations and not disruption of other routine operations or traffic flows; and vii) integrate all data in an enhanced visualisation user interface supporting decisions and viii) communication modules to allow for Vehicle-to-Infrastructure/-Everything (V2I/X)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Polynuclear manganese and manganese calcium complexes: searching for water oxidation catalysts'.

assistant: **Innovation**

The project deals with the synthesis and characterization of polynuclear Mn and Mn/Ca complexes as potential water oxidation catalysts. The “direct synthesis” approach in which zerovalent metals or metal oxides are employed as starting material will be used for the preparation of the polynuclear complexes. The isolated complexes will be identified by analytical methods (atomic absorption, CHN-analysis) and characterized by IR, UV-Vis, EPR spectroscopy, magnetochemistry, electrochemistry and single crystal X-ray diffraction analysis. Their catalytic activity in the reaction of chemical water oxidation by Ru(III) polypyridyl complexes will be tested. In the next step of the project, an oxidant will be generated by light irradiation from a Ru(II) polypyridyl complex and a sacrificial electron acceptor. The systems, in which the photooxidant not covalently linked to the Mn or Mn/Ca complex, will be investigated focusing on oxygen evolution measurement, EPR spectroscopy for the observation of electron-transfer from the Mn catalyst to Ru photosensitizer and by laser flash photolysis for kinetic evaluation of this process. In returning phase, reactive functional groups will be introduced into the most active manganese containing complexes. These building blocks then will be employed by Consortium for the synthesis of photocatalytic dyads and triads.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'ECOLOOP'.

assistant: **Concept**

ECOLOOP project develops and demonstrates a set of solutions to optimise the combination of different energy distributed sources (biogas, biomass, agri-PV, geothermal), meeting the local needs for electricity, heating, cooling, transport and waste and land management in rural areas, fostering regional development and creating benefits for farmers and foresters. The project solutions will focus on promoting the reduction of carbon footprint in rural areas by means of the higher penetration of distributed renewable energy sources, self-consumption and an optimal agricultural/forest waste management, while creating positive effects in biodiversity and soil health and reducing the risk on groundwater contamination. Following this approach, ECOLOOP objectives are:•To optimise the production of biogas from agriculture and forestry wastes in situ. •To combine in an efficient and sustainable way different distributed renewable energy sources (biogas, biomass, agri-PV, geothermal), meeting the local needs for electricity, heating, cooling, transport and waste and land management in rural areas.•To develop innovative renewable-based agricultural protocols and advance bioproducts to increase sustainability and circularity while creating positive effects on biodiversity and soil health and groundwater pollution.•To foster regional development in rural areas.ECOLOOP project will move towards a circular economy in rural areas, focusing on agriculture and forestry sectors, contributing to job creation, gender equality, biodiversity and climate resilience and adaptation. All the benefits provided by ECOLOOP solutions will be demonstrated in 4 pilot sites in Spain, Estonia, Bulgaria and Slovenia, involving different forest and agriculture natural conditions (climate, soils), size and ty
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable and intelligent management of energy for smarter railway systems in Europe: an integrated optimisation approach' (MERLIN) under Seventh Framework.

assistant: **Objectives**

MERLIN’s main aim and purpose is to investigate and demonstrate the viability of an integrated management system to achieve a more sustainable and optimised energy usage in European electric mainline railway systems.MERLIN will provide an integrated optimisation approach that includes multiple elements, dynamic forecasting supply-demand scenarios and cost considerations to support operational decisions leading to a cost-effective intelligent management of energy and resources through:•Improved design of existing and new railway distribution networks and electrical systems as well as their interfaces with the public grid and considering  network interconnections•Better understanding of the influence on energy demand of operations and operational procedures of the different elements of the railway system•Identification of technologies and solutions able to further contribute to the optimisation of energy usage•More efficient traction energy supply based on optimised use of resources•Understanding of the cross-dependency between these different technological solutions to define optimum combinations for optimised energy usage•Improving cost effectiveness of the overall railway system•Contribution to European standardisation (TecRec)MERLIN will also deliver the interface protocol and the architecture for energy management systems in the railway domain, combining the technical development with new business model that would enable and foster their application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Verified Exascale Computing for Multiscale Applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The purpose of this proposal is to enable a diverse set of multiscale, multiphysics applications -- from fusion and advanced materials through climate and migration, to drug discovery and the sharp end of clinical decision making in personalised medicine -- to run on current multi-petascale computers and emerging exascale environments with high fidelity such that their output is ""actionable"". That is, the calculations and simulations are certifiable as validated (V), verified (V) and equipped with uncertainty quantification (UQ) by tight error bars such that they may be relied upon for making important decisions in all the domains of concern. The central deliverable will be an open source toolkit for multiscale VVUQ based on generic multiscale VV and UQ primitives, to be released in stages over the lifetime of this project, fully tested and evaluated in emerging exascale environments, actively promoted over the lifetime of this project, and made widely available in European HPC centres.The project includes a fast track that will ensure applications are able to apply available multiscale VVUQ tools as soon as possible, while guiding the deep track development of new capabilities and their integration into a wider set of production applications by the end of the project. The deep track includes the development of more disruptive and automated algorithms, and their exascale-aware implementation in a more intrusive way with respect to the underlying and pre-existing multiscale modelling and simulation schemes.The potential impact of these certified multiscale simulations is enormous, and so we aim to promote the VVUQ toolkit across a wide range of scientific and social scientific domains, as well as within computational science more broadly. Scientific excellence and outr