RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ONCOLYTIC HERPESVIRUSES RETARGETED TO CANCER- SPECIFIC RECEPTORS', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cancer remains a major health burden worldwide. The aggressive targeting of metabolic pathways shared by normal and cancer cells results in prolonged survival and cures, but at a tremendous cost to patient life quality. What is missing is a therapeutic agent that clearly differentiates normal and cancer cells. This proposal delineates a process for killing exclusively cancer cells with no interference with normal cells. In the past two decades there has been considerable effort to develop attenuated viruses for killing cancer cells. Of the oncolytic viruses in clinical trials, attenuated herpes simplex viruses (HSV) are among the most promising because of safety, affinity for cancer cells, ability to treat patients multiple times without block by adaptive immunity. The shortcoming is that they do not discriminate between normal and cancer cells, are effective in a limited number of patients. The remarkable accomplishment by my laboratory at the basis of the proposal is the genetic engineering of HSVs that specifically infect and kill cancer cells and cannot infect normal cells. The prototype retargeted HSV targets HER2, a receptor in breast, ovary and other tumors. HER2-HSV ablates human breast and ovary cancers, and glioblastoma after intratumoral or intraperitoneal administration.This proposal addresses basic research issues for the advancement of retargeted oncolytic HSVs. It is organized in 5 AIMS• Engineer a non-cancer cell line for virus production acceptable to Health Authorities and re-engineer the retargeted-HSV accordingly. This will enable production of clinical grade retargeted-HSVs for clinical tests (AIM1)• Engineer retargeted-HSVs suitable for systemic delivery and for boosting anti-tumor immunity (AIM2-3)• Apply our platform to expand the repertoire of o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of spoken language comprehension processes in a verb-final language: Incremental interpretation of case marking cues in Turkish speaking children' (2007-2013).

assistant: **Concept**

In the last two decades methods have been developed to investigate moment-by-moment language comprehension in children. This research demonstrates that children’s language comprehension shares two crucial features with adults’: 1) interpretation is incremental such that each word is integrated as soon as it becomes available; 2) language comprehension at every level draws on multiple sources of information. But there is much left to learn, particularly about processes by which children combine word meanings to interpret sentences. Previous work that was mostly on rigid word-order languages like English has tended to emphasize that children’s comprehension is verb-based. The crucial question is whether the same mechanism is employed in verb-final languages. Adults in such languages have been shown to use case marking cues incrementally independent of the verb. To date, it is not clear whether children follow similar patterns. The present studies explore children’s real-time language comprehension in Turkish, a verb-final language with flexible word order and rich inflection. These studies will provide information about the sources and processes employed in comprehension, how they vary from language to language, and how they develop in early childhood. The proposal presents 3 experiments in the visual-world eye-tracking paradigm, which will be employed for the first time with Turkish-speaking children, to investigate when they develop the ability to use case marking cues to (A) predict how a sentence will unfold as it is being spoken (Experiment 1 & 2); and (B) make inferences about the verbal semantics of an event (completed/ongoing) (Experiment 3a & 3b). The main training objective of this research is to equip a European researcher with an expertise about the design, im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'QUANTUM SORTER'.

assistant: **Concept**

Q-SORT introduces a revolutionary concept whereby the TEM is employed as a Quantum Sorter. All TEM techniques are in fact limited to the imaging and energy spectroscopy of the electron wavefunction. Moreover, when a single sample property is sought, most of the image information is useless, a waste that cannot be afforded in dose-sensitive materials. The Quantum Sorter leverages the recently-acquired capacity to structure e-beams, which implies that if, in a quantum experiment (tunable state preparation, interaction, analysis), the analysis is performed over the ‘optimal’ basis of quantum states, very few electrons are necessary for the full characterisation of a sought property, i.e. the TEM can be tuned to answer a single question but with maximum efficiency. To this end, Q-SORT introduces a new parallel analysis strategy, based on a suitable conformal mapping of the wavefunction: the starting point is the analysis of orbital angular momentum (OAM), but building a recipe for diagonalising a wider range of observables is one of the planned Breakthroughs of Q-SORT. This will in turn allow Q-SORT to achieve three other high-risk Breakthroughs of vast applicability: assessing the OAM of plasmonic resonances in select nanoparticles, achieving atomic-resolution magnetic dichroism, identifying different proteins based on selected properties. We believe that the Quantum Sorter will become so important that it will eventually be part of every state-of-the-art TEM, since the new technology is easy to integrate with energy-loss spectrometry. The project consortium includes some of the world leaders in optical and electronic vortex beams, as well as in protein cryoTEM. A major industrial partner in TEM is included, so as to secure market penetration of technological outcomes. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Revealing Accreting Planets Through Observations and Refined simulations' (RAPTOR), addressing dissemination and exploitation.

assistant: **Impact**

Recent multi-wavelength observations disclosed a groundbreaking discovery—an accreting giant planet surrounded by a circumplanetary disk within the gap of the young circumstellar disk PDS 70. We now witnessplanet formation, one of the forefront themes in modern astrophysics, in action. With over 5,000 detected planetary systems, we have learned that nearly every star in our galaxy hosts at least one planet. The crucial insightinto how these planets form lies in the conjunction of theoretical studies and observations of magnetized dustyaccretion disks - rotating masses of gas and dust around freshly formed stars.Global magneto-hydrodynamical disk models reveal gas evolution, characterizing the accumulation of sub-micron grains and concentration of pebbles. Models with embedded planets and improved thermodynamicsshowcase the gap and ring structure formation. However, modeling both becomes essential when focusing on the scales of young planets. Which physical process determines the mass budget the planets can accrete? Manyobserved exoplanetary systems, such as TRAPPIST-1, show a distinct mass limit of several Earth masses. Whatprevents dust pebbles from further accreting onto these super-Earths? What is the role of the envelope and circumplanetary disk for giant planets’ gas and solid material content?Addressing these crucial questions requires a new class of models that incorporate (1) adaptive mesh refinement for mass tracking near the planet, (2) modeling of magnetic fields from circumplanetary disk scales to theplanet, and (3) radiative transfer for comprehensive heating and cooling across all scales, unveiling the envelopeand circumplanetary disk formation. The astonishing discoveries underline that the next generation of theoretical models is needed. The RAPTOR proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EuroConference Matrix 2001 - Chemistry and Physics of Matrix Isolated Species' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

MATRIX 2001 is planned as continuation of a series of biennial international conferences alternately arranged for more than 25 years in Europe and the USA (where the event is established as a Gordon Conference). The series, which started 1977 in Berlin, is the focal point for scientists worldwide employing matrix isolation and related techniques. Central points to this meeting are the presentation and discussion of new methods in the field, as well as the transfer of experience in the wide range of preparation and spectroscopic techniques to the younger generation taking up the challenge. This will be the first meeting organised in an Eastern European country, with the specific goal to facilitate attendance from young Central and East-European (Russian, Ukrainian) chemists and physicists interested and involved in using different types of matrices. The scientific program will put particular emphasis on phenomena, theories, experimental techniques and models, which promise to be of interest for scientists in more than one field of research. Matrix 2001 presents an opportunity, through invited talks, topical presentations, posters and informal discussion, to objectively assess the recent progress and highlight evolving directions.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00076-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'System  for  detection of  Threat Agents in  Maritime Border  Environment'.

assistant: **Concept**

The main objective of the SafeShore project is to cover existing gaps in coastal border surveillance, increasing internal security by preventing cross-border crime such trafficking in human beings and the smuggling of drugs. It is designed to be integrated with existing systems and create a continuous detection line along the border. One of the treats to the maritime coast are small Remotely Piloted Aircraft Systems (RPAS) which can carry explosives or which can be used for smuggling drugs, boats and human intruders on the sea shore. The SafeShore core solution for detecting small targets that are flying at low attitude is to use a 3D LIDAR that scans the sky and creates above the protected area a virtual dome shield. SafeShore will also integrate the 3D LIDAR with passive acoustic sensors, passive radio detection and video analytics.One of SafeShore specific objectives will be to cover 1500-m1800m along the coastal border. This will be done with 3 mobile platforms. Each one of those will cover itself with a dome-shaped virtual detection shield with a radius of about 250m to 300m. There will be approximately 50 meters overlapping between the platforms. The overlapping will create a continuous  detection shield along the shore. The SafeShore objective will be to demonstrate the detection capabilities in the missing detection gaps of other existing systems such as costal radars, thereby also ensuring the fusion of information and increasing the situational awareness and better implementation of the European Maritime Security Strategy based on the information exchange frameworks, EUROSUR and EUCISE 2020. All SafeShore objectives are measurable, realistic and achievable within the duration of the project, as the SafeShore project will build 3 prototypes that are going to as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Controlling Fluid Resistances at Membranes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Today’s materials research in the field of synthetic membranes gives access to highly permeable and extremely selective membranes. However, their potential will remain ineffective as high and selective transport rates always go along with resistances emerging at the membrane fluid interface in the form diffusion limitations in the laminary boundary layers. In order to make full use of the very many new materials, also new means to control and minimize such fluid based resistances need to be developed. Yet another phenomena disturbs the full potential use of membranes: retained solutes, colloids and biological matter accumulates at the membrane interface and causes irreversible fouling and scaling.The proposed research aims to develop a rigorous translational methodology to control and improve mass transport through the fluid/membrane interface. ConFluReM will establish Strategic Tools and New Instruments to:(1)    comprehend and quantify the prevalent mass transport resistances in representative membrane separation processes,(2)    synthesize and fabricate new nano-, micro- and mesoscale material and device systems as instruments to control and overcome the limitations of concentration polarization and fouling,Strategic Tools are experimental and simulation methods to quantify and engineer the mass transport and hydrodynamical properties of the new membrane systems. These encompass flow imaging (flowMRI, microPIV and microfluidic transport studies) as well as computational fluidic dynamics (CFD and CFDEM). New Instruments are synthetic and fabrication means as well as process condition means to improve mixing at the membrane/fluid interface. These encompass (a) lateral patterning of chemical topology of the membrane surface by printing and stamping, (b) shaping the 3D g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improvement of guava: Linkage mapping and QTL analysis as a basis for marker-assisted selection', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The proposal aims at improving the utilization of the perennial tropical fruit crop guava (Psidium guajava L.). This will be achieved by a consortium composed of three European laboratories and three institutions in Latin American producer countries. The re are two main activities foreseen: (i) Identification and characterization of new guava genotypes and their utilization in breeding programs according to the individual needs of the countries, and (ii) application of biotechnology in the form of DNA ma rkers by establishing individual molecular linkage maps for three existing mapping populations, aligning these individual maps into a reference guava linkage map with the help of microsatellite markers, mapping QTLs for traits important for breeding, and developing a Molecular Marker Set for marker-assisted selection. In specific, new guava germplasm will be conserved in situ and ex situ, its agro-morphological characters recorded according to established descriptors and complemented by molecular analys is using AFLP and SSR DNA markers. These two DNA marker types form the basis for establishing individual and reference molecular linkage maps in guava for three available mapping populations. These mapping populations will furthermore allow for the mappi ng of QTLs for important breeding traits and thus provide the basis for developing the Molecular Marker Set. Candidate genes for plant development and resistance will be identified and mapped onto the guava reference map. Finally, the project will disse minate its progress in the field by an international symposium and an associated practical course in biotechnology and bioinformatics.The proposal thus bears relevance to the priority area A.3.2 (Bio-diverse, bio-safe and value added crops) by proposing research to increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DEvelopment of MEthods and Tools for Evaluation of Research'.

assistant: **Concept**

The Lisbon Agenda of increasing competitiveness of European countries by the «knowledge» has focussed attention on RTD and education policies.The evaluation of such policies is in the state of the art very difficult;if there exist quantifications of RTD increase on economic performance at a firm or sectoral level,the assessment of such performance on a whole community or a group of countries is less frequent;the link between RTD and economic performance has,during the last decades,changed a lot,rising a doubt on the former estimations:for instance the knowledge spillovers between countries linked to RTD has increased,the services activities linked to RTD as increased also much and then the measurement of RTD did change in significance.The importance of other forms of intangible capital (Human, ICT,Organisational capital…) has modified the link between RTD and innovation.The overall objective of this proposition is to build a system of tools based on applied modelling that can be used for the ex ante evaluation of research and innovation policies at sectoral and European level.The method of the project will be a wide scope one. It will be based on micro,meso and macro economics,in order to give deep insight on the RTD incentives and the RTD performance;it will be grounded on Scientific and Technique and Innovation (STI) indicators and new databases that take into account all the activities related to RTD (and not only RTD expenses),the knowledge spillovers between activities and countries and also other forms of intangible capital.These insights will be used to modify the production block and demand of the two large scale detailed economic coverage models that have a good track record:the econometric model NEMESIS and the general equilibrium one GEM-E3 that will produce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Packaging of futuRe Integrated ModulAr Electronics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Affordable transport for the citizen relies on innovative solutions and technologies that will result in lower costs and lead-time of the aircraft and its systems. In this area, the packaging of on-board computers is an important contributor.The Packaging of futuRe Integrated ModulAr Electronics (PRIMAE) objective is to develop a new flexible, robust and open aeronautical packaging for the next generation of electronics and particularly to Integrated Modular Avionics. This new concept after standardization will be able to replace the 35 year old ARINC 600 standard.PRIMAE technical objectives are:- Reduce electronics packaging in terms of volume (50%) and weight (30%) and offer flexibility   and growth capability- Reduce costs (20%) using market standard components- Enhance reliability (50%) through thermal and vibratory breakthrough- Mitigate EMC protection penalties in composite fuselage environment- Ensure fast production ramp up and support rapid final assembly on aircraft- Improve availability and reduce maintenance cost.In these domains significant technological studies, beyond the state of the art (cooling, lightweight composite materials, electromagnetic interferences, power supply, connectivity), will be carried out in respect to airworthiness regulations.To achieve the PRIMAE objectives, 3 steps are required:- Definition phase of air framers and suppliers requirement- Research and evaluation of advanced packaging technologies- Specification and development of representative mock-up to integrate different technologies.The concept once harmonized among the main European players participating in this project, will be proposed as a standard for the future generation of large and regional aircraft, and helicopters. The new packaging concept will strengthen competiti