RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Re-engineering the tumor microenvironment to alleviate mechanical stresses and improve chemotherapy' in the context of a Seventh Framework call.

assistant: **Objectives**

Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of chemotherapies for many cancers (e.g. breast and pancreatic cancers and various sarcomas) is primarily because these agents cannot reach cancer cells in amounts sufficient to cause complete cure. The abnormal microenvironment of these tumors drastically reduces perfusion and results in insufficient delivery of therapeutic agents. Tumor structural abnormalities is in large part an effect of mechanical stresses developed within the tumor due to unchecked cancer cell proliferation that strains the tumor microenvironment. Alleviation of these stresses has the potential to normalize the tumor, enhance delivery of drugs and improve treatment efficacy. Here, I propose to test the hypothesis that re-engineering the tumor microenvironment with stress-alleviating drugs has the potential to enhance chemotherapy. To explore this hypothesis, I will make use of a mixture of cutting-edge computational and experimental techniques. I will develop sophisticated models for the biomechanical response of tumors to analyze how stresses are generated and transmitted during tumor progression. Subsequently, I will perform animal studies to validate model predictions and indentify the drug that more effectively alleviates stress levels, normalizes the tumor microenvironment and improves chemotherapy. Successful completion of this research will reveal the mechanisms for stress generation and storage in tumors and will lead to new strategies for the use of chemotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fostering Web Entrepreneurship in Europe: e-talent, e-mentoring, e-services and e-capital for e-entrepreneurs' (2014-2020).

assistant: **Innovation**

The ePlus ecosystem project will develop and deploy an online and onsite environment, building on and interconnecting existing ecosystems, hubs and initiatives, in order to setup a runway for web entrepreneurs to start and scaleup a business in Europe and grow internationally. This European ecosystem will help web-entrepreneurs to develop and scale up their ideas and businesses, from a business international validation phase, to internationalization, access to finance and to business growth, thus complementing the service offer currently made available at local ecosystems level. The ePlus project will meet the objectives stated in the workprogramme in terms of accelerating web entrepreneurship in Europe, and offer a unique new platform that answers to the need for new services expressed in the Startup Manifesto. It will provide the nurturing to help web-entrepreneurs go global, through a unique combination of talents, tools and services of an European scale in all key elements required to create great companies: team, concept, technology, and capital. This will be done through the following elements:- Putting in motion a true pan-european web-entrepreneurship ecosystem by setting up the initial backbone made of the interconnection between the booming regional ecosystems of Lisbon, Nice and Baden-Württemberg, combining and intertwining current services and opportunities and making room for more local ecosystems to join in;- Untap on Europe’s unique mass of + 50,000 skilled and mobile researchers generated by institutions such as the Marie Curie Actions in order to reinforce the web-entrepreneurs teams’ skills and technology grasp;- Guide web-entrepreneurs into global business concepts through a European mentoring scheme, building on the best regional and national program
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards inclusive research programming for sustainable food innovations' under Seventh Framework.

assistant: **Concept**

Over the past decade, most EU Member States have identified food and health as key priorities. This is in response to increases in obesity and diet-related chronic diseases such as diabetes and cardiovascular diseases amongst their populations. Also an insufficient nutrient supply in subgroups of the populations and special demands in ageing societies are identified as abiding challenges. Attempts to increase public awareness of appropriate ways to eat more healthily though do not seem to have led to significant changes in patterns of food purchase and consumption. It has become obvious that the development of effective measures for improvement is a demanding task and requires further systematic research and innovative approaches. One main question that this research needs to tackle is the role that innovations in foods (e.g. improved nutrient preservation through the use of mild pathogen inactivation) and new basic research technologies (e.g. for gaining greater insight and understanding of the mechanisms underlying the effects of food intake on health) could play in counter-acting the alarming rise of food-related health problems. Advocating and promoting the production of knowledge that is close to the concerns of European citizens the European Commission has emphasized that simply inventing new technologies is not enough to overcome the pressing societal challenges in Europe (European Commission 2009). In the first place, it requires a purposeful communicative exchange between research, business, and civil society actors on the nature of the problem and the role that innovative products and technological approaches (besides or complementary with social measures) could play in tackling it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Clean Energy Production through Roadway Surface Power Harvesting Systems for Increased Safety in the Transportation Sector' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

POWERAMP will design, manufacture, prototype, and validate through real world pilots energy harvesting speed bumps that capture energy from vehicles that pass over the ramps. Emplaced in areas where speed must be controlled, safety must be increased, or where vehicles must come to a stop, such systems leverage gravity and the kinetic energy of thousands of kilograms moving at high rates of speed to produce energy. Breaking technological barriers associated with patent protected background, POWERAMP will enable the associated SMEs to obtain systems that produce 35kW of continuous power in moderate traffic conditions. This is the equivalent of 200m2 of solar panels or one moderate sized windmill for a footprint of approximately the size of a car and at a fraction of the cost. As such, POWERAMP will provide an enabling technology for Europe to meet its energy and emission reduction goals. POWERAMP will also provide a tool to increase the safety of pedestrians at crossing areas and construction workers at worksites through controlled speed, powered signs, and safety lighting. Europe currently has approximately 8000 pedestrian fatalities on its roadways each year. Similar to wind, solar, or hydro, POWERAMP will pioneer a new sector of clean energy production - roadway energy harvesting, and will change how we think about roads and how they are integrated into the built environment. A wave of new applications will become possible and an entire job sector will be created.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DEcision Support system for Smart Agriculture' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Fertilizers and conventional pesticides have been used in agriculture to improve crop yield and control plant pests. However, the excessive and uncontrolled application of agrochemicals has had a negative side effect on both environment and human health. Contamination of water and soil as well as death of non-target species are a few of the environmental effects whilst these pesticides have carcinogenic effects on humans. The EU implemented Directive 128/2009 on Sustainable Use of Pesticides, which incorporates a crop protection practice called Integrated Pest Management (IPM). Rather than solely relying on agrochemicals, in IPM all plant protection measures are considered jointly with the necessary actions that prevent pest population growth. IPM is complex and farmers require decision support systems to assist them in making the best choice about plant protection measures to be taken. Our consortium – agricultural expert Agri2000 Net and ICT/IT specialist 3CiME Technology – has created DESSA, a service which provides accurate, farm-specific information to farmers on the plant protection actions to be performed based on farm conditions. Our system is IoT based and consists of sensors placed on the farm which measure key parameters (e.g. pest/spore presence, humidity, moisture). These parameters are input into cloud-based software that incorporates plant models that have been constructed using Agri2000 Net’s years of agricultural research on plant. The software consists of algorithms that process the data and output to the farmer, in a user-friendly manner on smart devices, the exact measures that must be performed. The decision support is given to the farmer in real-time, based on the conditions on each farm. DESSA results in 15-20% increased plant productivity, 10-30%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulation of neuronal apoptosis in the hippocampus during cell death in response to toxicological or pathological conditions' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content Apoptosis has been only recently acknowledged as possible contributor to toxicological and pathological neurodegeneration. However, the molecular mechanism underlying apoptosis has been studied mainly in non-neuronal cells. Therefore, the aim of this research proposal is to study the involvement of an apoptosis-associated gene-family, the bcl2-gene family, in the onset of an in vivo model system of neuronal apoptosis, i.e. adrenalectomy-induced apoptosis in the rat hippocampus. Firstly, I will study the expression of different members of the bc1-2 family by in situ hybridization and quantitative PCR experiments. Secondly, the effect of up-and down regulation of relevant members on apoptosis will be studied using hippocampal slices treated genetically modified retroviruses. The results of the proposed research may provide new leads for pharmacological intervention strategies for several neurological disorders in response to toxic agents. Training content (objective, benefit and expected impact) Objective: Understanding molecular mechanisms regulating the process of neuronal cell death. Benefit: By learning the molecular biology in addition to her cell biological knowledge of the process of cell death, the applicant will be able to perform research in a more multidisciplinary way. This multidisciplinary approach is nowadays required in the field of pharmacology and toxicology, i.e. apoptosis. Through working at the ICRF, which is a center of excellence on molecular biology of apoptosis the quality of the molecular biological training is ensured. Impact: The acquired knowledge of introducing genes by viral transduction and successful manipulation of apoptosis in the brain may have impact for the clinical situation and provide valuable clues
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nano-Particles for Fuel Cells' (NAFCELL) targeting Sixth Framework.

assistant: **Abstract**

This research aims to produce novel catalysts for fuel cells by understanding the preparation and structure of nanoparticles used in fuel cell anodes and cathodes. The benefit of this project is that it brings together two disciplines: the chemistry of making catalysts and the engineering of the fuel cells in applications.This is an important thing to do now because fuel cells are not satisfactory in applications like combined heat and power since the catalyst performance is insufficient and too expensive at present.New catalysts are especially needed in China where carbon dioxide emissions and global warming are set to rise alarmingly in the coming decades. The objective of this project is to develop new high performance and economic nanoparticle catalyst s for fuel cells.This will involve 5 subsidiary objectives.- Synthesize nanoparticle catalysts of Pt, Ni and base metals, especially to produce new degrees of aggregation in their structure.- Characterising the nanoparticles to define the new structures, compositions and processes will be a major part of the project. Scanning probe microscopy (SPM) and nanosizer dynamic light scattering (DLS) will be the main measurement methods, together with electron microscopy.- Focus on the interpretation of the promoting effect of added elements such as ruthenium or molybdenum on the nanoparticles, either Pt for PEMFCs or Ni for SOFCs, when synthesized by various techniques. Cells will be made from the new materials and tested.- Study interaction of the catalysts with the support structures and electrolyte membranes in fuel cell systems.- Transfer this new knowledge to China where substantial new power generation is needed in the next 20 years.It is expected that substantial performance improvements and cost reductions will resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ECONOMIC MANUFACTURING PROCESS OF RECYCLABLE COMPOSITE MATERIALS FOR DURABLE HYDROGEN STORAGE' (ECOHYDRO), addressing dissemination and exploitation.

assistant: **Impact**

ECOHYDRO aims to develop a new energy efficient filament winding process of hydrogen storage tanks using recyclable materials. We will improve the thermoplastic acrylic resin for in-situ polymerization, which has been used for wind energy and marine applications so far, for the high-speed filament winding process by optimizing the UV polymerization of the resin and developing new filament winding tools and equipment. Especially, we will develop multi-functional resin with fire-resistance, thermal insulation and self-healing capacity which are expected to enhance the safety of hydrogen storage, and hybrid tows to reduce microcracking. We will develop a recycling technology to recover 100% of carbon fibres and resin from hydrogen tanks after their end-of-life. These recovered materials will be used for the rewinding process for new tanks manufacturing. This recycling and rewinding technology will contribute to significant reduction of the cost and of carbon footprint of hydrogen storage tanks. To improve the safety and durability of hydrogen tanks, a new structural health monitoring technology via sensor integration into the tanks in service life, will be developed in combination with data science using AI algorithm. These sensors embedded into the tank during the manufacturing process will be used to monitor the soundness of filament winding process in real time to improve the yield ratio. The developed technologies will be validated by four different types of industrial demonstrators (TRL4) using either compressed gas hydrogen storage cryogenic liquid hydrogen storage, such as aboveground station, tube trailor, truck and bus, and aviation. The industrial partners of ECOHYDRO (Tier 1, end-users) will validate the demonstrator development and prepare a future plan for a h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Frontiers Inside Roman Sicily: Culture, Economy and Society between Late Antiquity and the Early Byzantine Period'.

assistant: **Concept**

The Late Antique and Early Byzantine periods are crucial ones for the understanding of Sicily's socio-economic and cultural evolutionfrom Antiquity to the Middle Ages. Recent research has shown that the island still played its centuries-old role then as aMediterranean linchpin, and this realization has awakened scholars' interest for a period that has been dogged by an adversehistorical bias (one of perceived ‘decline and decadence’) for a long time. A raft of new data from archaeological excavations and fieldsurveys have sketched the outlines of the nuanced complexities of Sicilian society and its vibrant economy at this period, and itsintegration into multiple Mediterranean trade routes. Despite some progress overall, delay in the publication of old excavations, thepaucity of syntheses available, and the difficulty in accessing existing datasets, are a hindrance to resolving some key problems aboutthis important transitional phase in Sicilian history. For this reason, many scholars believe that a new multidisciplinary analysis of theperiod is essential. The FIRS project therefore focuses on four key sites in western Sicily, investigated during the second half of the20th century but largely unpublished. These comprise the rural settlements of Campanaio and Castagna and the port cities ofPalermo and Lilybaeum (Marsala). By analysing the quantity of material culture from the excavations and exploring the distribution ofartefacts at a micro-regional scale, we aim to investigate the many and various causes that triggered changes in trading patterns,social behaviour, and cultural practices between the 5th and the 7th centuries AD. The expected results will undoubtedly affect theinternational scientific community dealing with similar issues in other Mediterranean regions. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional and molecular characterization of excitatory layer IV neurons in mouse visual cortex' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

What developmental processes are responsible for establishing the sensory preference of cortical neurons? In visual cortex, neurons belonging to a particular class (e.g. morphologically similar neurons in layer IV) are diverse in their functional properties, including receptive field size, and spatial and temporal frequency preference. For each neuron, these response properties are primarily defined by the pattern of inputs it receives. On one hand, these inputs could be selected by stochastic or activity-dependent processes during development. On the other hand, the pattern of inputs may be guided by molecular factors that ultimately determine functionally distinct neuronal subtypes. In other words, an apparently homogeneous cell type may in fact comprise several functionally distinct subclasses established by their patterns of gene expression.Specifically, we will test (i) whether a morphologically homogeneous population of excitatory neurons is diverse at the level of their individual transcriptional profiles, (ii) whether any transcriptional differences between individual neurons are related to their visual response properties, and (iii) whether their molecular identities persist in the absence of structured visual input. To this end, we will extract the mRNAs and determine the transcriptional profile of individual neurons whose visual response properties have been characterised in vivo, using methods developed in the host lab. Together, this proposal will attempt identify the contribution of molecular determinants to shaping connectivity and response properties of cortical excitatory neurons.