RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inflammatory neuropathy cause and treatment' (1994-1998) under Fourth Framework.

assistant: **Objectives**

To standardise assays for antibodies to glycolipids in human sera.To identify antibodies to glycolipids which are diagnostically useful in inflammatory neuropathy.To improve the management of inflammatory neuropathy with carefully co-ordinated controlled trials of promising new treatments. Inflammatory neuropathies are acute or chronic paralysing disorders which affect more than 40,000 European citizens at any one time. INCAT participants lead international research into their cause and treatment. We have shown that:increased concentrations of inflammatory mediators and,antibodies to nerve glycolipids are present in the blood of patients with inflammatory neuropathy.These antibodies cross-react with antigens in bacteria which triggered the inflammation.The antibodies block nerve conduction or nerve-muscle transmission.Further our treatment trials, the largest undertaken in the world, have shown that:5. blocking these antibodies by intravenous infusion of large amounts of normal human immunoglobulin is an effective treatment of acute inflammatory neuropathy.6. According to our preliminary evidence intravenous immunoglobulin may also be effective in chronic inflammatory neuropathy.INCAT will combine the resources of the leading European laboratories which have pioneered these advances with the leading glycolipid purification laboratory (CHU-NANTES) to explain in detail the cause and pathogenesis of inflammatory neuropathy. INCAT also unites the leading European neuropathy clinical trial centres to undertake trials of intravenous immunoblobulin in three types of chronic inflammatory neuropathy which would be impossible at a National level. Both interlinked components of this project thus fulfil the BIOMED 2 subsidiarity principle. The project involves the transfer of glyco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Spatially Multiplexed Spectrophotometry' under Horizon 2020.

assistant: **Concept**

As a result of the research undertaken in the NANOFORCELLS project (ERC-StG-2011-278860), Dr Montserrat Calleja’s team has successfully developed instrumentation for the investigation of cell mechanics. The NANOFORCELLS project proposes a tool-box of three converging technologies for the aim of discriminating cancer and healthy cells from their physical properties: AFM, label-free microscopy and nanomechanical sensors. The instrument object of commercialization through the FAST-SPECTRO project is the output of the second key technology development: label-free microscopy.  The research undertaken under ERC support has evidenced that cell lines with different degrees of tumorigenicity show different mechanical properties, a result confirmed by AFM and nanomechanical tests. Such results are found to have a potential interest for cancer diagnostics, We envision a high commercial potential of the technique. In order to accelerate the market entry of the results, the FAST SPECTRO “Proof of Concept” (PoC) project will focus on conducting a market feasibility study of the SMS instrument developed, as well as clarifying the IP position strategy and making an initial approach to potential partners and investors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced laser ablation barrier films for organic and large area electronic devices' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The overall objective of this project is developing organic electronic building elements on flexible substrates with monolithically integrated barrier foils as substrate. The barrier acts as the inevitable protection against atmospheric gases as water vapor and oxygen, as the most crucial agents for unwanted material degradation processes. This topic is one of the keys for enhancing both the performance of TOLAE components and addresses some of the main technology barriers of TOLAE: lifetime and cost-performance-ratio.Organic photovoltaic (OPV) modules have been chosen as test objects for a scalable and general approach suitable also for other TOLAE devices. Monolithical integration of barrier foils means in this case that the full device is made immediately on top of ultra-barrier coated plastic foil, which further is coated with a transparent electrode. This leads to significant cost reduction, which is one of the key needs for wider use of TOLAE devices.The project ALABO develops direct laser scribing processes on flexible substrates, coated with ultra-barrier systems. The project results will be applicable to a number of TOLAE technologies, such as OPV, OLED, OTFT and thin-film inorganic PV on polymer foil substrates. The consortium will investigate and develop new manufacturing processes, which will increase the performance and functionality of TOLAE devices suitable for smart systems. OPV can be part of such smart TOLAE systems. By developing direct laser structuring on top of such ultra-barrier foil, the consortium develops advanced materials, as well as new production technologies supported by dedicated monitoring and material testing technologies for well-scalable manufacturing processes. As an outcome, more functionality will be integrated into less material,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting the regulatory logic of cell fate reprogramming through integrative and single cell genomics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The concept that any cell type, upon  delivery of the right “cocktail” of transcription factors, can acquire an identity that otherwise it would never achieve, revolutionized the way we approach the study of developmental biology. In light of this, the discovery of induced pluripotent stem cells (IPSCs) and cell fate conversion approaches stimulated new research directions into human regenerative biology. However, the chance to successfully develop patient-tailored therapies is still very limited because reprogramming technologies are applied without a comprehensive understanding of the molecular processes involved.Here, I propose a multifaceted approach that combines a wide range of cutting-edge integrative genomic strategies to significantly advance our understanding of the regulatory logic driving cell fate decisions during human reprogramming to pluripotency.To this end, I will utilize single cell transcriptomics to isolate reprogramming intermediates, reconstruct their lineage relationships and define transcriptional regulators responsible for the observed transitions (AIM 1). Then, I will dissect the rules by which transcription factors modulate the activity of promoters and enhancer regions during reprogramming transitions, by applying synthetic biology and genome editing approaches (AIM 2). Then, I will adopt an alternative approach to identify reprogramming modulators by the analysis of reprogramming-induced mutagenesis events (AIM 3). Finally, I will explore my findings in multiple primary reprogramming approaches to pluripotency, with the ultimate goal of improving the quality of IPSC derivation (Aim 4).In summary, this project will expose novel determinants and yet unidentified molecular barriers of reprogramming to pluripotency and will be essential to unlo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Engineering nanoparticle-polymer interactions to create instructive, tough nanocomposite hydrogels without negatively impacting self-healing behavior for bone tissue regeneration' (Nano4Bone), addressing dissemination and exploitation.

assistant: **Impact**

Self-healing hydrogels are investigated as promising biomaterials in tissue and organ regeneration applications, offering a powerful alternative for scarce donor tissue. However, these hydrogels are often insufficiently tough, which is a significant limitation in their clinical use. Another drawback is that there are limited solutions on how to instruct cells for tissue healing. Thus, one key challenge is to develop self-healing hydrogels that are mechanically strong and can guide tissue regeneration. However, current methods to improve the mechanical properties of hydrogels negatively impact self-healing behavior.In Nano4Bone, I aim to provide a novel solution to this challenge by engineering nanoparticle polymer interactions using metal-ligand coordination bonds, which, uniquely, are both stable and labile; ideal properties for creating spontaneous self-healing hydrogels. The nanoparticles act as dynamic crosslinkers to increase local crosslinking densities, thus dramatically improving the mechanical properties without affecting the self-healing behavior. Importantly, the nanoparticles can also act as bioactive units through smart incorporation of therapeutic ions to instruct tissue-healing behavior. The metal ligand bond can be tuned for temporally controlled release of bioactive nanoparticles, a novel approach which allows kinetic control over bioactive signals. To prove their clinical utility, I will optimize the materials to treat and regenerate bone tissue in osteosarcoma (OS), for which new treatment options are urgently needed. Nano4Bone proposes an innovative method to drastically improve the mechanical properties of hydrogels without negatively impacting their self-healing abilities. The impact of the project will be large by addressing key challenges in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Empowering parents through the development of an online evidence-based mental health promotion school engagement resource', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The promotion of children’s mental health and wellbeing is fundamental to achieving strategic objectives of the EU health policy. Schools are recognised as a key setting to support and enhance children’s social and emotional wellbeing. Evidence to date indicates that school interventions have the greatest impact when they are focused on linking children, teachers and parents in the promotion of positive mental health. To date, however, there is an absence of research and resources to assist schools in supporting parental engagement in mental health promotion. The proposed research aims to address this crucial gap in school mental health. The study will adopt a systematic approach to developing an evidence-based resource for primary schools which is designed to assist school staff in establishing collaborative relationships with parents and align parent and teacher practices in promoting children’s mental health. In order to achieve this, the applicant will (i) systematically review current evidence on existing school-parent engagement frameworks and resources (ii) develop an online school-parent engagement resource based on the current evidence and consultation with school community stakeholders (iii) evaluate the implementation and efficacy of the online resource when implemented as part of a whole school mental health intervention that is being trialled in ten primary schools in Twente. This research will be carried out in collaboration with Prof Bohlmeijer at the Dept. of Psychology, Health and Technology and the Centre of eHealth Research and Disease Management at the University of Twente. The applicant will receive expert training from the Centre of eHealth Research in the development of technology supported mental health interventions. Under the guidance of Prof B
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Transnational Healing: Therapeutic Trajectories in Spiritual Trance' (THETRANCE) under Horizon 2020.

assistant: **Objectives**

This multi-sited comparative ethnographic research has three objectives: 1. to examine the transnational mobility of practices and concepts related to spiritual healing and trance; 2. to compare the use of these practices in the therapeutic trajectories between spirituality and biomedicine of patients in North and South America, and Europe; and 3. to investigate the role of religious/spiritual learning in patients' health and well-being. In order to achieve these objectives, THETRANCE asks the following questions: how do therapeutic practices involving spiritual trance move and settle transnationally? How do trance-based healing practices become part of the therapeutic trajectories of people moving between spirituality and biomedicine? How do participants learn and narrate about spiritual trance, with what kinds of consistencies and differences across cultures, and how are these relevant for therapeutic purposes? Through an approach that combines social and medical anthropology, and the anthropology of religion, drawing parallels with research in psychology and psychiatry, THETRANCE focuses upon a specific cases of people learning spiritual trance for therapeutic purposes, for physical and mental health and to recover from substance addictions. The methodology is grounded in a multi-sited comparative ethnographic research in temples of the Spiritualist Christian Order Vale do Amanhecer (Valley of the Dawn) in Brazil, the United States, Portugal and Italy. THETRANCE is innovative in combining the analysis of therapeutic trajectories between spirituality and biomedicine with the focus upon the process of learning spiritual trance through a transnational perspective. In doing so, it unsettles pathological reductions of spiritual trance to understand how these experiences a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Action on Global Life Sciences - Food Forum' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The EAGLES Food Forum is a multilateral review, strategy and communications programme which will strengthen the European responses to the global challenges posed by food security, quality, safety and agriculture, including environmental conservation, in the developing world. The programme has been designed and will be implemented by a group of leading EU and DEC life scientists, regulatory and communication specialists, and ethicists in the agriculture and food area. The aims are 1) to review and define strategies of food, agriculture and biotechnology research, in Europe and with a world-wide perspective, in view of tackling global challenges and meeting the needs of developping countries and 2) to encourage open and balanced dialogue with the European public, media and opinion formers about the needs and competencies of the DEC in this specific sector. The Project has five main components: 1. The EAGLES Management and Communication Office supervised by the EAGLES Steering Committee will coordinate the programme, in particular stimulating the flow of information - including via the creation of a dedicated web-site - about the effect of European and worldwide food, agriculture and biotechnology programmes and policies in/for the developing world; 2. The EAGLES Steering Committee will supervise the project on a practical basis for the duration of the project, and give input and advice to the project activities. 3. EAGLES Food Reports will assess the scale and effectiveness of relevant European and international policies and programmes; 4. EAGLES Food Forum Consultative Meeting and Symposium will discuss these policies and programmes and propose recommendations, amendments and additions; 5. EAGLES Food Workshops will review and define strategies on selected topics for sub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'StreP (Stretchable PV foil)' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

CO2 neutral energy generation is needed for climate change. PV can solve a large portion of this need. In densely populated areas, theuse of land is scarce and therefore PV integrated in the built and living environment is preferred to make double use of land area.Flexible PV sheets already exist, but the present PV sheets cannot be stretched or elongated like textile that is placed under stress. Theexisting PV sheets can be rolled and bended, but not elongated, which is important when the PV sheets would be integrated into e.g.the architectural textile. This project aims to solve this problem by making the interconnection between the solar cells stretchable.This would open many opportunities to integrate these PV foils in applications where the flexible sheets are placed under severemechanical stress or tension.In this project we will use flexible CIGS PV cells, which are also used in the present flexible PV modules. To allow stretching of the foilunder mechanical stress, it requires a special interconnection technology. A patent pending technology has been developed to createa series interconnection between the flexible solar cells, that at the same time can be stretched several millimeters, so that anelongation of 3 to 10% of the PV foil would become possible.This would be new and opens the possibility to integrate the PV foil in any tent-like structure. Applications we foresee are:- PV integrated in tents for refugee camps. Integration of the PV on the tents itself, will create immediately energy generation at themoment of setting up the tents.- Agricultural PV is a fast-expanding PV segment. For this application, the resistance to wind pressure is an important factor andstretchable PV would be a solution to overcome that problem.- Architectural textile is used for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tumor Endothelial Cells: Gatekeepers Of Anti-Tumor Immunity' to be submitted under Horizon 2020.

assistant: **Abstract**

Immunotherapy, in the form of immune checkpoint inhibitors, is the upcoming anti-cancer therapy, but suffers resistance in large fractions of cancer patients (also lung cancer). Tumors stimulate angiogenesis to ensure their supply of nutrients, however much less studied is how tumor endothelial cells (TECs) contribute to immunosuppression. Endothelial cells (ECs) represent a major non-hematopoietic component of immunity and TECs are presumed to be immunosuppressive, in part by expressing elevated levels of PD-L1. However, the role and dynamics of TEC-expressed PD-L1 in anti-tumor immunity relative to the cancer expressed PD-L1 remain incompletely understood.Given the strategic “1st line” location of TECs, the question raises if at least part of the success of PD-L1 inhibition, is attributable to an effect on TEC immunity. Therefore, for the 1st time, I will fill this gap of knowledge by characterizing mice lacking PD-L1 in ECs and assess tumor progression and anti-tumor immunity in these mice using different tumor models. I will assess the efficacy of anti-PD-L1 blockade in mice lacking PD-L1 in ECs in different stages of tumor growth to delineate the dynamics of PD-L1 expression in TECs. Moreover, by using established in vitro approaches, I will study the effect of PD-L1 knock-down in human lung tumor derived TECs vs. normal ECs on human T cell proliferation, effector function and transmigration. The proposed research provides unprecedented insights in the relative role of tumor endothelial vs. cancer cell-derived PD-L1 in immunosuppression.This is a multi-disciplinary project at the interface of angiogenesis, immunology and cancer. Combining my expertise on T cell biology with the host’s expertise in angiogenesis and exceptional scientific infrastructure (core facilit