RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel approach for the accurate quantitation of micro/nanoplastics in environmental compartments: a spatial-temporal distribution study in Valencia, Spain' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Plastic pollution is an issue of environmental concern intensively discussed in the scientific literature and public media in recent years. Particularly, microplastics (MPs) and/or nanoplastics (NPs) are a kind of pollutants potentially hazardous for ecosystems and human health that can be ingested by aquatic fauna. In this context, the presence of MPs and a lesser extent of NPs have been reported in the environment and biota. However, the detection of these pollutants generally it happens through techniques that allow its identification and characterization but have not enough sensitivity and/or accuracy to provide quantitative reliable results. Therefore, this project will focus on developing an accurate and reliable analytical procedure by liquid chromatography coupled to high resolution mass spectrometry for monitoring the occurrence and spatial-temporal distribution of MPs and NPs in environmental compartments and the further risk assessment in environmental and human health. This project shows an interdisciplinary nature that involves environmental, analytical chemistry and social sciences research field. This latter, considering the anthropogenic approach of this action. In addition, this proposal includes a two-way transfer of knowledge between the researcher and the host institution, as well as the training of the researcher in new advanced techniques both at the host as partner institution. The results of this project will allow to correlate the presence of MPs and NPs with anthropogenic and seasonal factors through accurate analytical methodologies. Moreover, it will allow a better understanding of risks of MPs and NPs pollution for environmental and human health, providing data that could be used by policymakers. To emphasize, this project is aligned with th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'European Prevention of Alzheimer’s Dementia Consortium'.

assistant: **Innovation**

Background:The secondary prevention of Alzheimer’s dementia (AD) is achievable if we can identify individuals at risk of disease progression defined by biomarker evidence of AD pathology and no or only minimal clinical symptoms and engage them in a standing adaptive clinical trial, of the highest quality, testing multiple interventions. To achieve this, EPAD will also provide the analytical infrastructure to make correct observations regarding an intervention’s value as an agent for secondary prevention. All this must exist in the right ethical, legal and social context. It must also be sustainable by being of value to numerous partners and stakeholders in the long term. The EPAD Consortium has been carefully designed to achieve the aim of secondary prevention of Alzheimer’s dementia.Current and recent drug development programmes in AD have been limited through the collection of heterogeneous samples of patients with advanced brain disease and an inability to measure effectively an index of disease course modification.Recruiting participants from clinics and the community for AD prevention trials with limited clinical background is both a risky and cost-inefficient strategy. Creating a disease register of people consented to enter secondary prevention trials delivers a degree of readiness that ensures better knowledge of a participants suitability and a more rapid throughput of screening for the trials. The EPAD Consortium has the necessary reach and influence from its partners to develop such a ‘readiness’ cohort.By delivering an earlier, risk stratified population with run-in data in the EPAD Cohort across both clinical and biological domains; we can ensure a more homogenous population for study. We can also track changes in disease status as the basis for deciding on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The key to precise and accurate cosmology:  Simulating the physics that shapes gaseous haloes' (COSMIC-KEY), addressing dissemination and exploitation.

assistant: **Impact**

Observational programs aimed at mapping the large-scale structure of the Universe, such as eROSITA and Euclid, are ushering in the era of Precision Cosmology. Our knowledge will soon transition from being limited by statistical errors, to being hindered by systematic uncertainties. These systematics arise from the theoretical modeling adopted to fit the data and the complex physics of galaxy formation, whose effects are often neglected. In fact, powerful feedback processes from supermassive black holes (SMBHs) affect the phase-space and thermodynamical properties of the gas within haloes and beyond, in turn modifying the expectations for the cosmological observables and the large-scale matter distribution. In order to fulfill the potential of observational cosmology, we must take a far-reaching step forward by a) designing novel types of large-scale simulations that model gaseous haloes and the effects of SMBH feedback to unprecedented levels of realism and by b) providing quantitative and trustworthy — that is, physically-motivated and observationally-validated — prescriptions for cosmological analyses. Starting from the well-validated IllustrisTNG hydrodynamical simulations, we will extend their scope to more massive systems with a new suite, TNG-Cluster. We will provide a library of baryon-informed formulae for cosmological constraints with galaxies, groups, and clusters as well as design novel observational tests for SMBH feedback models. Going beyond the state-of-the-art, we will develop numerical models that account for the effects of the multi-phase structure of the gas, of radiation, and of more sophisticated SMBH physics by using new simulation techniques and by complementing the AREPO code with on-the-fly machine learning-based methods. These will enable groun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SPinal INnovation Europe;  The development of a porous, titanium implant for the treatment of vertebral fractures' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Vertebral compression fracture (VCF) is a high impact disease with significant societal and economic costs. The annual direct economic burden of VCFs in Europe is € 37 billion. For VCF decreased quality of life is reported since the affliction is associated with severe morbidities, such as chronic disabling pain. Surgical intervention can stabilize the vertebra and prevent immobility due to the fracture. In the current treatment the vertebra is filled with special bone cement. Due to the relatively high risk of dangerous complications (~ 1-5%), alternatives to this treatment are being sought.Amber Implant sees a huge market opportunity to revolutionize VCF treatment. For this, Amber Implants is developing an expandable osseo-inductive spinal implant called the AIM+, to restore a fractured vertebra to its original height and the spinal column’s optimal anatomy without the use of bone cement.To efficiently and successfully develop the AIM+ Amber Implants seeks to expand the in-house knowledge on medical engineering and aims to acquire expertise on anatomy/biology and quality assurance & control. Up till now the company has been relying on costly external expertise. Internal expertise will provide the flexibility to adjust and optimize validation procedures and to optimally design the AIM+. The company needs to add biological expertise to successfully develop a model to predict osseointegration. Furthermore, skills and knowledge on human anatomy are sought to facilitate in-house preclinical testing. The integration of novel expertise and knowledge of the IA is expected to give Amber Implants a significant advantage on the market.The IA will play an important role in the structure of the company and he/she can have impact on the strategy and success of Amber Implants. The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of novel fluorinated reagents for preparation of drugs.'.

assistant: **Objectives**

Around 20% of all modern drugs are fluorinated organic molecules. During the recent years, however, pharmaceutical companies struggle to deliver novel drugs to the market, because of the lack of innovative practical reagents and reactions towards “drug-like” compounds.    In this project, we will address this issue by discovering novel small fluorinating reagents - fluorinated diazoalkanes, - elaborate their practical reactions, and use this knowledge to develop alternative synthetic approaches to some known drugs (AS-136A, Celecoxib).


**Keywords:** fluorine, novel reactions, novel reagents, trifluoromethyl, drug discovery
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hypotensive peptides from milk proteins' in the context of a Fifth Framework call.

assistant: **Objectives**

Milk protein peptides can inhibit angiotensin-I-converting enzyme (ACE) Drugs, which inhibit ACE, are in widespread use in cardiovascular medicine. Little or no information is available on the physiological efficacy in man of ingesting natural milk protein peptides/hydrolysis's, which inhibit ACE in vitro. Therefore, it is proposed to address this European-wide functional food ingredient problem/opportunity. The proposal objectives are to perform a detailed physiological, physicochemical, immunochemical and catechetical characterisation, in addition to a consumer assessment of these naturally derived inhibitors of ACE. Milk proteins will be hydrolysed using food-grade proteases. Clinical/bio availability trials will be performed in human volunteers. Immunochemical studies will use serum samples from humans fed ACE inhibitory hydrolysis. Catechetical studies will use human cell culture systems. Consumer awareness will be assessed on a global basis. The outcome of this proposal should lead to the development of clinically validated health claims in respect to the physiological efficiency and safety of ingesting milk protein-derived inhibitors of ACE.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Massive Sets of Heuristics for Machine Learning' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project aims at developing new machine learning methods relying on very large number of hand-designed heuristics, together with statistical tools to facilitate the design of these heuristics in an open and collaborative framework.We define an heuristic to be any algorithm processing raw inputs to produce values relevant to the problem at hand. This purposely very general definition encompasses techniques spanning from simple signal processing to symbolic modeling or locally trained predictors. Since we assume high performance can only be achieved by combining hundreds of such heuristics, we propose to develop them collaboratively, in a way similar to the successful development process of open-source software or collaborative encyclopedia.We will assess the performance of that strategy on the control of an avatar in a realistic 3D simulator and on the control of a real robotic arm, and we aim at creating a generic software platform usable on alternative applications.Hence, the key aspects of this proposal are to:- develop novel statistical techniques for prediction and goal-planning with a very large heterogeneous set of features,- develop statistical tools such as similarity measures in the space of features to help the design of very large sets of heuristics by many contributors,- assess the efficiency of this approach on a series of complex tasks in a realistic simulated 3D environment and with a real robot arm.The five partners of the consortium are from the fields of applied and theoretical statistical learning, reinforcement learning, artificial vision and robotics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting assembly of infectious HIV particles' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

AIDS remains one of the major life threatening infectious diseases in the world today. A constant supply of novel antiretrovirals (ARVs) is needed to respond to the limitations of current drugs. By the end of 2007, the therapeutic arsenal against HIV is expected to comprise ARVs blocking all major steps of HIV replication, except for particle assembly and budding. Members of HIV-ACE were instrumental in recent breakthroughs concerning virus assembly and Envelope incorporation into virions. On the basis of novel and fully validated targets, the objectives of HIV-ACE are: i) Assay development, drug screening and pre-clinical development of small molecule inhibitors of Capsid assembly and Env incorporation, up to the stage of Early Drug Candidates with acceptable toxicity profile determined by ADME/Tox studies, activity against multi drug-resistant viral strains and primary non-B isolates, antiviral activity in primary T cells and macrophages (WP1); ii) Elucidation of 3D structures of these validated targets and rational drug design guided by molecular modelling and docking of inhibitors (WP2); iii) validation and exploitation of the HIV-susceptible transgenic rat model to allow preclinical in vivo-evaluation of novel drug candidates from HIV-ACE and to provide the European pharmaceutical industry with an efficient in vivo-platform for predictive testing of any kind of anti-HIV drug (WP3); iv) Elucidation of the mechanisms responsible for activity of the validated inhibitors, and discovery/validation of novel targets in the budding pathway of HIV-1 (WP4). HIV-ACE is composed of 8 teams from 5 European countries, including a Biopharma SME, led by prominent world-class scientists in Virology, Cell Biology, Immunology, Organic and Medicinal Chemistry, working in highly regard
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An enzyme-based self-oscillating gel' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems.I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Workshop on cell biology of plant and fungal tip gowth""' to be submitted under Fifth Framework.

assistant: **Abstract**

Tip growth is a type of cellular growth that is represented in many and diverse cell types, which are important to plant breeding (pollen tubes), agriculture (root hairs) and plant and animal pathology (fungal hyphen). The understanding of tip growth forms the basis of the future use of these organisms as model systems for cell growth in basic research as well as for their exploitation in biotechnology and control of the harmful activities. Hitherto there have been very few attempts to bring together diverse approaches on diverse organisms to enhance interdisciplinary studies of the process. We propose to organise a workshop with the best international people working on the different aspects of tip growth. This long-felt need for an international forum will finally be established.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'using Virtual Reality and Archaeoacoustic Analysis to Study and exhibit Presence' (VRAASP) targeting Horizon 2020.

assistant: **Abstract**

Unusual acoustic signatures of ancient or historical spaces, such as the West Kennet Long Barrow in England; caves in northern Spain containing prehistoric art; or Sculptor's Cave in Scotland, have captured the public imagination for centuries. Attentive listeners often hear or feel a presence or resonance within such acoustic spaces, sometimes described as an otherness, a shimmer or glow, or an audio-visual aesthetic experience of the space. There is evidence that this sense of presence is brought on by the perceptual conflation of where and what streams of information in the brain. Other acoustic incongruities (such as infrasound) play a role in the experience of spaces and the acoustic experience of presence contributes to the phenomenology of historical and archaeological sites. The perception of presence is especially common in historically sacred locations (and shimmer is a characteristic descriptor of the spiritual realm), and thus acoustic analysis of the phenomenology of presence provides insight into the source of this experience. Acousticians, composers, and acoustic archaeologists have studied acoustic phenomena, and archaeologists have compiled 3D models of archaeological sites for cultural preservation and exhibition purposes. The ER will use these technologies to engage in creative practice-led research on the phenomenology and acoustic archaeology of space. This research will contribute new knowledge on the phenomenology and psychoacoustics of archaeological spaces, and will also improve virtual archaeological spaces by imbuing them with their original sense of presence. Through this project the ER will develop skills in 3D visual and acoustical modelling, VR simulation, numeracy, data analysis, sound reinforcement, publication preparation, presentation,