RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineering of Superfluorescent Nanocrystal Solids' under Horizon Europe.

assistant: **Concept**

The time is right for light-emitting colloidal nanocrystals to meet the demands of the second quantum revolution. The cooperative emission (superfluorescence) was recently observed in the micron-sized solids of colloidal lead halide perovskite nanocrystals, offering a path to low-cost, solution-processed sources of bright and coherent light. Superfluorescence, characterized by high-intensity and ultrashort bursts of indistinguishable photons, makes nanocrystal solids desired targets for photonics and quantum information applications. However, the exact origin of the superfluorescence is debated, and the rules of nanomaterial design for on-demand cooperativity are unknown.PROMETHEUS tackles these issues by combining nanochemistry with spectroscopy and tools of quantum optics. The project's approach consists of 1) synthesis and judicious selection of emissive metal halide nanocrystals with minimal exciton energy inhomogeneity, 2) accelerated self-assembly of nanocrystals into binary solids with a tunable fraction of emitters, 3) cryogenic micro-photoluminescence spectroscopy at the level of individual nanocrystal solids. The control of the coupling between emissive nanocrystals is achieved by diluting optically-dense nanocrystal solids with a second, transparent nanocrystal component. Measurements of spectroscopic observables, coherence, and photon statistics on single nanocrystal solids are used to dissect the roots and properties of cooperative emission.The project introduces a concept of light-coupled nanocrystal solids where light-matter interactions are engineered through structure and composition. This concept goes beyond metal halides and applies to emissive nanocrystals of any shape, opening a class of colloidal nanomaterials with light emission controllable betwe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Light-based technologies for the decontamination of powdered infant formula' to be submitted under Seventh Framework.

assistant: **Abstract**

Powdered infant formula is the most widespread and established alternative to the breastfeeding of the newborn. Despite preservation steps during production illnesses caused by contaminated formula as a result of Salmonella spp., Cronobacter sakazakii have been reported, which can often lead to brain damage or death in babies and infants. The use of extremely high temperatures during sterilisation can cause a great degree of protein denaturation. Considering the naturally lower content of lysozyme and lactoferrin of cow’s milk, which is the base of infant formulation, these ingredients have to be added at a cost to match more closely human milk, and are severely denatured by excessive heat treatment. As such, there is a need to provide manufacturers with a reliable treatment method that is effective in the inactivation of microorganisms and does not diminish the nutritional quality of the formula.Past research has shown the effectiveness of light technologies for surface decontamination in packaging, for treatment of transparent and non-transparent beverages, and for the decontamination of vegetative microorganisms. Moreover, the combination of different light technologies can enable short exposure times. Researchers have successfully applied light technology to reduce the bacterial load in infant formula spread on a flat surface. This project will develop a novel system for the reduction of microbial contamination of infant formula by using a more gentle temperature processing based on 2 types of light in combination with a fluidised bed system. The system will be safe, effective, affordable, energy efficient, and environmentally friendly. By preventing the use of excessive temperatures, the risk of protein denaturation will be reduced. Moreover, by combining the light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Molecular Principles of Mammalian Axonemal Dynein Assembly'.

assistant: **Innovation**

Motile cilia are tiny microtubule-based projections which create fluid flow and are essential to human health. Cilia movement is powered by coordinated action of complex macromolecular motors, the axonemal dyneins. During differentiation, as cells produce hundreds of motile cilia, millions of dynein subunits must be pre-assembled in the cytoplasm into very large complexes in the correct stoichiometry which are then trafficked into growing cilia. This poses a sizeable challenge for the cell in terms of allocation of a significant fraction of the global translational machinery for streamlined assembly of dyneins within a crowded cellular space. The key question remains: How does the cell know how much is enough? This is an extreme example of a common problem in cell biology. Responsive and adaptive mechanisms must exist to prevent futile expenditure of cellular resources in making a surplus of large molecules like dyneins that may also pose a risk of toxic aggregation. While a well-defined transcriptional code for induction of cilia motility genes exists, the translational dynamics and subsequent feedback circuitry coordinating dynein pre-assembly with ciliogenesis remain unexplored. The molecular logic underlying the construction of motile cilia assembly are still not fully understood. The ambitious nature of CiliaCircuits proposes to use super-resolution and systems approaches to elucidate key mechanisms regulating this process in health and disease. Human genetics tells us that making cilia motile is a complex process. To date, almost 40 genes have been implicated in primary ciliary dyskinesia (PCD), the disease of motile cilia, for which there is no cure. The long-term vision is to understand this dynamic control operating over a specialized proteome in time and space
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanoporous Asymmetric Poly(Ionic Liquid) Membrane' (NAPOLI) under Horizon 2020.

assistant: **Objectives**

Nanoporous polymer membranes (NPMs) play a crucial, irreplaceable role in fundamental research and industrial usage, including separation, filtration, water treatment and sustainable environment. The vast majority of advances concentrate on neutral or weakly charged polymers, such as the ongoing interest on self-assembled block copolymer NPMs. There is an urgent need to process polyelectrolytes into NPMs that critically combine a high charge density with nanoporous morphology. Additionally, engineering structural asymmetry/gradient simultaneously in the membrane is equally beneficial, as it would improve membrane performance by building up compartmentalized functionalities. For example, a gradient in pore size forms high pressure resistance coupled with improved selectivity. Nevertheless, developing such highly charged, nanoporous and gradient membranes has remained a challenge, owing to the water solubility and ionic nature of conventional polyelectrolytes, poorly processable into nanoporous state via common routes. Recently, my group first reported an easy-to-perform production of nanoporous polyelectrolyte membranes. Building on this important but rather preliminary advance, I propose to develop the next generation of NPMs, nanoporous asymmetric poly(ionic liquid) membranes (NAPOLIs). The aim is to produce NAPOLIs bearing diverse gradients, understand the unique transport behavior, improve the membrane stability/sustainability/applicability, and finally apply them in the active fields of energy and environment. Both the currently established route and the newly proposed ones will be employed for the membrane fabrication.This proposal is inherently interdisciplinary, as it must combine polymer chemistry/engineering, physical chemistry, membrane/materials science, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Standardization and validation of the in vitro use of respiratory epithelial cells for toxicity assessment of inhaled occupational and environmental agents' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Foreseen ResultsDevelopment, by pooling research efforts, of standard methods for the preparation and culture of alveolar type II pneumocytes, nonciliated bronchiolar (Clara) cells and airway (bronchial, tracheal or nasal) epithelial cells from animals and humans.Development of standard methods to expose respiratory cells in culture to inhalable agents (gaseous agents).Validation of the use of respiratory epithelial cells in toxicology by assessing, in different laboratories, the effects of selected model compounds (gases) using sensitive tests of cell injury and dysfunction. A specific aspect is to assess irritant potentialFormulation and sound recommendations on the use of respiratory lung cells in culture for testing inhalable agents.The proposed concerted action aims to contribute to the respiratory health protection of workers and citizens, exposed to agents that may be inhaled from the occupational or general environment.The rationale for this approach is that :the burden of respiratory diseases as a result of exposure to occupational and environmental pollutants is considerable in workers and citizens from Central and Eastern Europe;research is needed to define occupational and environmental exposure standards on the basis of adequate scientific evidence and understanding of mechanisms, so as to protect the entire population against common and novel risks;neither conventional in vivo toxicity testing in laboratory animals, nor epidemiology and clinical or occupational surveillance are sufficient to obtain rapid, adequate and relatively inexpensive information about mechanisms of toxicity, interactions of differents agents or newly introduced substances;in vitro respiratory toxicology is a promising and scientifically valid alternative, which is, however, still in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DRiving InnoVation in crisis management for European Resilience' in the context of a Seventh Framework call.

assistant: **Objectives**

DRIVER+ starts from the experience that neither successful R&D nor strong end-user demand always lead to innovation in the Crisis Management (CM) domain. This is a problem since as societies become more complex, increasing scope and unpredictability of potential crises and faster dynamics of major incidents put increasingly stringent demands on CM. European CM capabilities already constitute a mature System of Systems; hence wholesale redesign would often be too costly and might critically destabilise existing CM capabilities. Therefore DRIVER+ focuses on augmenting rather than replacing existing capabilities. DRIVER+ has three main objectives: 1) Develop a pan-European Test-bed for crisis management capability development; 2) Develop a well-balanced comprehensive portfolio of crisis management solutions, and 3) Facilitate a shared understanding of crisis management across Europe.The DRIVER+ Test-bed will provide the technological infrastructure, the necessary supporting methodology and adequate support tools. The Portfolio of Solutions (PoS) is a database driven web site that documents all the available DRIVER+ solutions. The PoS includes information on the experiences with a solution (i.e. results and outcomes of trials), the needs it addresses, the type of practitioner organisations that have used it, the regulatory conditions that apply, societal impact consideration, a glossary, and the design of the trials. Initially, the PoS will contain information about the solutions that are already available within the consortium; the PoS will be extended with third-party solutions when required by the trials, and ultimately opened up for any external organisation to share data and experiences on solutions.A series of trials will be conducted during which solutions will be op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Determining centromere assembly mechanisms and improving mitotic fidelity during somatic cell reprogramming' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Maintaining a stable karyotype is essential for the use of pluripotent stem cells (PSCs) in regenerative medicine and translational and basic research. Although around 10-30% of PSC lines present karyotypic abnormalities, the molecular mechanisms underlying this genomic instability are largely unknown. Centromeres, the chromosomal loci that drive chromosome segregation are central to mitotic fidelity. Maintenance of centromeres in somatic cells is tightly cell cycle coupled, as centromeric chromatin assembly is strictly dependent on G1 phase transition. PSCs have an atypical cell cycle structure with truncated gap phases and proliferate at unusually rapid rates. How this affects mitotic fidelity in general, centromere assembly in particular and consequently, genomic stability is an essential question in reprogramming biology. The aim of this multifaceted project is to determine the mechanisms regulating proper chromosome segregation during somatic cell reprogramming to induced PSCs (iPSCs). By combining fluorescent labelling techniques, high-end microscopy and genome-wide analysis, this project will determine the mechanisms of centromere assembly and inheritance in PSCs, the consequences of genome-wide remodelling of chromatin marks during reprogramming on the stable epigenetic propagation of centromeric chromatin and how functional modulation of key centromere assembly factors affect mitotic fidelity. This project capitalises on the unique combination of the researcher’s experience in stem cell biology and iPSC technology and the extensive expertise in the biology of human mitosis and centromere function of the host lab. The results of this study will provide direct insight into how chromosomal segregation is controlled in PSCs and most importantly during reprogramming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of DOT1L in regulating the epigenetic signature of cardiomyocytes during heart development' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Understanding mechanisms underlying cardiomyocyte (CM) transcriptional regulation is critical for deciphering molecular origins of cardiac malformations. Epigenetics is crucial for stabilizing transcriptional programs, but little is known about the “epigenetic code” of histone methylation during cardiogenesis, and in particular the role of histone methylation at lysine 79 (H3K79me) during heart development. DOT1L is the sole enzyme that catalyzes methylation at H3K79. Different degrees of H3K79me lead to distinct transcriptional readouts (gene activation, repression, or no changes of transcription) in a context dependent manner. H3K79me fluctuates during development, with Dot1L expression being high in heart. My initial studies in mouse embryonic stem cell-derived CMs suggested that DOT1L is required at early stages of cardiogenesis. ChIP-seq results from neonatal and adult CMs show H3K79me2 enriched in genes encoding CM structural proteins and cell cycle regulators. The foregoing suggest a critical role in heart development, but the role of DOT1L and the specific functions of H3K79me during early CM development in vivo have not yet been studied. My preliminary data showed that early CM specific cKO of Dot1L, driven by xMLC2cre, results in lethality at P2, with a phenotype exhibiting increased CM proliferation, demonstrating an essential role for DOT1L in cardiogenesis and CM cell cycle regulation. My hypothesis is that DOT1L plays a key role in heart development, defining a H3K79 dependent epigenetic landscape essential for cardiogenesis and CM cell cycle regulation. To test this hypothesis, my Aims are: 1)To investigate effects of early CM-specific deletion of Dot1L on cardiac morphogenesis and CM cell biology 2)To identify genes directly regulated, by DOT1L mediated-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Smart Control of Demand for Consumption and Supply to enable balanced, energy-positive buildings and neighbourhoods' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Future buildings and neighbourhoods are expected to combine a manifold of Energy using Products (EuP") ranging from electrical lighting to HVAC with locally available renewable energies (e.g. solar, wind) and with locally available storages (e.g. car batteries). An intelligent management of energy in such a local grid would enable customers to participate in the energy market and even contribute to the stability of the power grid. The problem is that such an energy management requires fine grained infrastructure and expensive hardware. Today, this limits applicability of energy management to large consumers in the industrial and commercial sector.<br/>The objective of SmartCoDe is to enable the application of advanced techniques for energy management in private and small commercial buildings and neighbourhoods by<br/>1)\tDeveloping new methods for automated energy management that specifically considers the requirements of Energy using Products in homes / offices and local renewable energy providers, considering the required information security and dependability.2)\tDeveloping an inexpensive hardware/software implementation that can be integrated into arbitrary Energy using Products, providing them with the ability to communicate and to remotely control its use of power.3)\tDemonstration of technical and economic feasibility and benefit of intelligent energy management in buildings and neighbourhoods with an initial focus on electric lighting.<br/>If successful, the project will allow all manufacturers of EuP to add energy management functionality (and maybe additional features such as remote control, etc.) for very little additional cost, and thereby address a new and huge market in homes and offices. The local energy management will enable local entities to participat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A perspective on computerized severe accident management operator support' (SAMOS) targeting Fifth Framework.

assistant: **Abstract**

To investigate the possibility of a computerized operator support tool(comptool") during a severe accident at a NPP to further enhance the existing tools, notably the in the EU widely used Westingh. Owners Group (WOG) Severe Accident Management Guidelines (SAMG), by making use of the CAMS system developed in the OECD Halden Reacter Program and Comb. Engineering logic diagrams. The comptool should support and enhance the WOG-SAMG tools (decision diagrams, computational aids) by validating available signals from I&C, track missing information, update pre-calculated decision points in the SAMG scheme, indicate potential success paths, keep track of actions performed, generate insights in the plant damage states, estimate the time to major events with due consideration of uncertainties, prioritise system restoration, estimate source terms for off-site actions. The comptool should support and facilitate the difficult decision making in the stressful environment of a severe accident.Many nuclear power plants have implemented guidelines to prevent and mitigate the consequences of severe accidents (SAMG). These guidelines contain a number of high level actions, to be initiated upon symptoms of core damage. It is anticipated that information available may be unreliable as instruments maybe damaged or beyond their design range. The proposed project investigates the possibility to improve insights and the actions taken by computerized support. This support should enhance the existing paper tools (a/o actualise decision diagrams, computational aids), validate available signals, identify success paths, estimate the plant damage state, keep track of actions performed, indicate the time to major events ahead (with due consideration to uncertainties), estimate source terms. The project