RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '3D glyco-engineered models to address the role of glycosylation in gastric cancer clinical management' (GlycoModels).

assistant: **Concept**

Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer death. Its late diagnosis accompanied with a bad prognosis keeps this malignancy among the most deadly. After generations of cancer therapy based on chemical drugs causing severe side effects and limited efficiency, cancer treatment undergoes a paradigm shift towards targeted therapy, employing both monoclonal antibodies and small molecule inhibitors of receptor tyrosine kinase activity, as the most promising tool for the years to come. However, there are numerous patients that do not respond to these novel treatments due to mutations in downstream signalling pathways or to undefined molecular mechanisms. Protein glycosylation has been shown to modulate cellular receptor functions and alter antibody binding affinities and therefore foreshadows to play a major role in cancer therapy resistance. The GlycoModels project aims to identify glycan alterations on cell receptors that lead to targeted therapy resistance of gastric tumours. Using cutting-edge gene editing techniques, gastric cancer cell lines will be glyco-engineered to express hallmark glycan epitopes and applied in 3D-culture systems as advanced models mimicking the tumour microenvironment. These 3D-GlycoModels will display differential response to treatment with the most promising targeted therapy agents for key cell receptors (HER2, VEGFR, MET and RON) involved in growth, progression, and spread of cancer. In-depth analysis of the GlycoModels, covering glycan characterisation of the cell receptors, disclosing activated signalling pathways, and transcriptomics will unveil our understanding on driving mechanisms in therapy resistance and the glycosylation patterns involved. The structural valid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and dissemination of benchmarking for increasing cost-efficient district heating' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The objective of the project is to develop a benchmarking concept for district heating enterprises with the aim of improving energy efficiency, environmental impact, economy and socio-economy. Benchmarking is seen as a tool for improvement of the performance of district heating companies and for increased economic transparency enabling comparison of energy services and performance of different enterprises. The work is focusing Denmark and Poland specifically and the Baltic Sea region in general where large potentials for improvement of energy efficiency, environment and of technical, economic and socio-economic performance. The objective will be achieved through development of a benchmarking methodology and tool, through networking and dissemination of results in co-operation with approximate 30 district heating enterprises in Denmark and Poland.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of advanced surface technology for extended resistance in extreme environment' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

ASTERIXE is aiming at developping innovative combined surface treatments promoting a technological breakthrough for high performances in the field of Environmental Barrier Coatings (EBC's). These coatings play a key role in high temperature, highly corro sive environments and high mechanical stress conditions. The goal of the project is to open new routes of surface engineering by combining coating deposition and advanced post treatment technologies (pulsed e-beam (PEB) and laser). The understanding of t he phenomena interacting on the coating composition and structure will be improved all along the project with the creation and optimisation of a model predicting the coating composition and structure after post treatment.The coatings will be deposited by different processes, electrochemical, spray or vapour deposition, the process choice being mainly dependent on the elemental composition needed to fulfil the application requirements. The pulsed e-beam and laser treatment will be used to give the coatin g its final structure and morphology together with an interface melting promoting coating to base material alloying. As a result, the coating process will be optimised in one hand, by using the results of the predicting model, and in other hand, by testi ng new combinations with respect to the chemical composition (new chemical systems, hybrid layers, self repairing coatings?). This will be obtained through:-a new concept of interface treatment leading to enhanced coating adhesion strength by simultaneou sly melting of the coating and the substrate surface. -a new process of extremely fast surface quenching from the melt leading to values of density and toughness of the surface layer close to the theoretical bulk" values without affecting the substrate material. -a new r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SinuShunt – New disruptive medical device for treatment of hydrocephalus' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Hydrocephalus is a devastating neurological condition caused by accumulation of cerebrospinal fluid (CSF) on brain, and If left untreated, it can be fatal. The only treatment option is surgical, either implantation of a shunting device placed centrally in the brain, or, in some cases, by use of an endoscope going through the brain substance to its central part.  The main problem in the industry is that conventional treatment systems (shunts) are based on a technology from 1950s and they are failing on average in 4-8 years, due to blockage or over-drainage. This results in 100 000 re-operations annually and brings a lot of complications (incl. increased infections) to the patient. Furthermore, this inefficiency represents an additional cost of €1.5B for the health care systems annually.  To offer a solution to these problems, CSF-Dynamics is developing a new disruptive implantable medical device for treatment of hydrocephalus. The main innovation is draining the cerebrospinal fluid into sinus vein that is a natural resorption place of CSF, instead of conventional chest or abdomen.  The hunt system uses novel stent technology as an outlet into the sinus vein, to avoid obstruction. SinuShunt competitive advantages are: 1) significantly increased life-time of the shunt, therefore reducing amount of re-operations; 2) Better quality of life for the patient due to the close to normal drainage of the brain-fluid, avoiding over-drainage and complications thereof. Hydrocephalus market is currently valued at €1.2B and is expected to reach a value of €1.6B by 2023. The market is steadily growing at CAGR of 4.4% during this time period. The market growth is propelled by growth in aging of population, increasing awareness of the condition and constantly improving diagnostic tools. Ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decarbonizing energy: Mapping and modelling the global energy sector's Asset owners, investment choices, technological pathways, and Political influence' (MAP) targeting Horizon Europe.

assistant: **Abstract**

The urgent need for rapid decarbonization of the global energy sector to meet Paris Agreement goals requires more robust policies based on a deep understanding of the sector’s key economic actors, investment decisions and incentives, and influence on policymaking. However, these factors have not yet been thoroughly studied. The MAP project addresses this critical research gap by examining, at the global level, primary energy supply firms' physical investment, categorized by technology - dirty, clean, or options like CCS potentially diverting resources from cleaner alternatives. These investments will be traced to the firms’ ultimate owners, whether governments or shareholders. Additionally, MAP will analyze how ownership, control, and board structures influence energy and climate policies. Ultimately, the project aims to identify the most effective policy mixes for achieving rapid decarbonization of energy, considering these dynamics. MAP will employ empirical, econometric and network analysis to study investment patterns, ownership structures, and their influence on climate and energy policymaking. It will also develop an agent-based model to simulate policy scenarios and assess policies' effectiveness. The project will provide insights into energy decarbonization's industrial and political economy dimensions by integrating economics, network analysis, energy system modelling, and political science.Hosted at UniCA within a leading multidisciplinary research group and supervised by Prof. Mauro Napoletano, an expert in agent-based models and network analysis, the project will produce cutting-edge research. The fellow, expert in climate economics, innovation, and concentration, will contribute to the group's research and knowledge exchange. This fellowship will broaden th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'AEROdynamicsTotal Regulatory Acceptance for the Interoperable Network' in the context of a Seventh Framework call.

assistant: **Objectives**

The certification of a rail vehicle according to European regulations, Technical Specifications for Interoperability, European Standards and national safety rules represents a significant element of both vehicle cost and time to market. Indeed, a large part of vehicle certification mandates testing for safety, performance and infrastructure compatibility. AEROTRAIN will help meet the business scenarios listed in the ERRAC SRRA 2002 and 2007 by aiding the spread of European homologation and acceptance procedures to speed up interoperable product approvals while squeezing out risk through improved safety management. In the field of aerodynamics a recent EN focuses on common definitions and descriptions of the aerodynamic phenomena and measurement procedures. Due to the application to all types of rail traffic it has not converged yet to one method per phenomenon but allows variations arising from national rules. The focus of the project is therefore on using the TSI route to consolidate the methodologies allowing the free exchange of certification data.The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of the certi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Addressing key uncertainties in mineral DUST EmiSsion modelling to better constrain the global dust cycle' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Mineral dust emission is ubiquitous in arid and semi-arid areas, representing a serious hazard for health, environment, and economy in many countries, in particular some of the least developed. Dust is a dominant contributor to the global aerosol load and plays a significant role in different aspects of climate and atmospheric chemistry. A key uncertainty in estimating present-day dust emissions is the contribution of human activities such as cultivation and grazing that disturb the soil. Recent research allowed representing natural and anthropogenic dust sources in global models based on high-resolution satellite data and land use maps. However, the accurate quantification of dust emissions and their attribution to natural and anthropogenic origin is currently hampered by deficiencies in dust emission modelling. Deficiencies include an incomplete representation of the physics of dust emission and a lack of skill to model certain atmospheric processes driving dust emission. DUST.ES will constrain present-day global dust emissions for both source types (natural/anthropogenic) taking into account (1) aerodynamic entrainment, a potentially important, yet previously neglected dust emission mechanism; and (2) moist convective dust storms (haboobs), intense dust events, which are unrepresented in global models, but  have a big impact on society. DUST.ES will estimate the regional and global relative significance of dust emissions caused by different dust emission mechanisms, meteorological dust injection processes, and source type. Results of DUST.ES will be a cornerstone to the longer-term goal of quantifying the effects of anthropogenic dust sources in the present and future climate. The beneficiary (BSC) hosts the WMO Dust Storm Prediction Regional Center for North Africa,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Astrophysics of Neutron Stars' (ASTRONS), addressing dissemination and exploitation.

assistant: **Impact**

The basic research topic is the study of neutron stars and their environments. Scientifically, neutron stars provide a basic component of research on compact endpoints of stellar evolution, with crucial links to central problems of astronomy. For physics, neutron stars are of interest because they offer the largest quantities (solar masses!) of the most extreme condensed matter under (albeit indirectly) observable conditions. In particular, problems associated with the determination of masses and radii of neutron stars, with all the connections and implications to other theoretical and observational problems, provide an important focus for the current ToK project.The group in Turkey is accomplished, with an emerging group of young scientists and students, needing further training and research links on theory, data analysis and observational aspects of neutron star research. The field of instrumentation for high energy astrophysics and training for future European space missions, XEUS in particular is an important direction of this ToK project, where training is needed for the scientific and technological extension and integration of the group into the European research area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Refined solid-state nmr techniques for distance determinations and frameworkcharacterization in crystalline microporous materials'.

assistant: **Objectives**

Research objectives and content Protocols for applying innovative solid-state NMR techniques such as REDOR and TEDOR to accurately measure internuclear distances will be developed for characterizing the structures of crystalline inorganic microporous solids. These techniques will be applicable to other advanced materials. Fluoride ion locations will be determined in a selection of high quality, as-synthesized zeolites and microporous aluminophosphates produced from non-alkaline, fluoride-containing media. Detailed information regarding fluoride ion environments and the roles these ions play during the syntheses will be obtained. Improved understanding of these framework structures and the guest species within their channels and pores will provide insight into the mechanisms of their catalytic activity, and ultimately result in enhanced synthetic methods and novel applications of these important materials.  Training content (objective, benefit and expected impact) Expertise will be transferred between members of the research team, and the group at ENSCMu will obtain valuable new techniques for characterizing advanced materials. Several young scientists will be trained in innovative analytical and synthetic methods. Instructional and supervisory roles will foster teaching and leadership skills. Existing inter-European and industrial collaborations will also be strengthened.  Links with industry / industrial relevance (22) Numerous industrial processes currently exploit the kinds of crystalline inorganic microporous materials which will be characterized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HOLISTIC AND INTEGRATED URBAN MODEL FOR SMART CITIES', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

STARDUST serves as smart connector bringing together advanced European cities and citizens of Pamplona (ES), Tampere (FI) and Trento (IT) - with the associated follower cities of Derry (UK), Kozani (GR) and Litomerice (CZ). These six cities, collaborating with relevant industrial partners, including a variety of innovative local SME, and supported by academia and research centres will demonstrate three lighthouse cities, deploy intelligent integration measures, test and validate technical solutions and innovative business models, and deliver blueprints for replication throughout Europe and abroad. The objective of STARDUST project is to pave the way towards the transformation of the carbon supplied cities into Smart, high efficient, intelligent and citizen oriented cities, developing urban technical green solutions and innovative business models, integrating the domains of buildings, mobility and efficient energy through ICT, testing and validating these solutions, enabling their fast roll out in the market .The core idea of the STARDUST project is the demonstration of different “innovation islands” as urban incubators of technological, social, regulatory and market solutions which, once validated, could contribute to this objective of transformation of our cities towards Smart Cities. The integrated approach of STARDUST is based in the combination of technological solutions with human being reflected in joint decision making, economic constraints, citizen’s governance, etc. The STARDUST Smart City concept has been designed to enhance the integration of all these aspects to define a new Urban Metabolism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of Chelators and Fluorescent Sensors for Deleterious Metals Implicated in Neurodegenerative Diseases' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The recent approaches to Alzheimer’s and Parkinson’s diseases reflect the current concepts of copper(II) and iron(III) involvement in the ethiology of these disorders. Therefore, the development of imaging tools capable of sensing the distribution of these two deleterious metals as well as the design of novel treatment strategies are currently at the focus of attention. In my return project to the Faculty of Chemistry, University of Wroclaw, Poland, and in the framework of internationa l scientific collaborations, I would like to study new chelators designed to selectively bind copper(II) and iron(III) cations and to pass the blood-brain-barrier. A series of ligands possessing two or three bidentate groups based on oxygen and nitrogen do nor sets will be examined. The attachement of the fluorescent probes to these compounds or the presence of fluorescent binding sites will lead to a quenching process induced by the coordination of copper(II) and iron(III) and provide very sensitive analyti cal tool for the determination of traces of these cations. This phenomenon could also be used to image and localise accumulations of these metals in physiological tissues. A powerful combination of potentiometry, absorption and emission spectrophotometry a nd electrospray mass spectrometry will be used to determine the stoichiometry of the cupric and ferric complexes and the corresponding stability constants. Zn(II) and Ga(III) will be chosen as probes of Cu(II) and Fe(III) respectively for NMR measurements. Cyclic voltammetry will be used to determine the electrochemical properties of the metal complexes as well as the electron transfer mechanisms. The coordination processes of Cu(II) and Fe(III) with the newly synthesised ligands will be also determined by kinetic measurements in th