RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neuronal NanoCarbon Interfacing Structures' (NeuroCare) targeting Seventh Framework.

assistant: **Abstract**

NeuroCare aims to create better retinal, cortical and cochlear implantable devices through the use of improved interfacing between the electronic implants and living cells. The NeuroCare concept involves low-cost, carbon-based materials, well-adapted for medical implants, because they (i) offer wide range of electronic properties (metal, semiconductor and insulator), (ii) are bio-inert and (iii) are physically robust. Coupling between electronic devices and neurons was recently studied using “soft”, nanocrystalline diamond-based micro-electrode arrays, evaluated in laboratory animals for retinal stimulation. These diamond implants considerably reduced gliosis, enabled stimulation currents to be raised by more than one order of magnitude before causing visible chemical alteration, and enabled long lasting operation with reduced biofouling. Our previous experience with nanocrystalline diamond will be directly built upon through the introduction of atomic layers of graphene to diamond surfaces.NeuroCare will specifically focus on:• Carbon-biointerface development offering reduced biofouling over the state-of-the-art, as set by the DREAMS project and improved biocompatibility• Interfacing of rigid MEAs and FETs with cells and organs to improve bidirectional communication with neurons for in vitro research and pharmacological applications• Nanoscale surface engineering and flexible macroscale implant materials for optimal contact to biological tissue• Making and testing implantable MEAs and FETs for complex multichannel neuronal communication - targeting the specificity in vivo of the implantable devices for 3 high-impact clinical applicationsNeurocare partners will test interfaceable and implantable devices via in vitro and in vivo testing.NeuroCare federates 12 partners: C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Discreet Organic Superluminophores'.

assistant: **Innovation**

Considering that all life on Earth ultimately relies on the interaction of carbon-based organic matter with light through photosynthesis, it is unsurprising that organic molecules which absorb and emit light broadly overarch scientific disciplines, with great implications in modern technologies related to sensing, bioscience, electronics and energy.Organic “superluminophores” (SLs) (J-aggregates) afford a unique synergy of properties, with fundamental advantages over traditional dyes – they absorb light more strongly and emit light more quickly and efficiently. Their sharp absorption and emission spectra also endow high colour purity and are desirable for selective and efficient excitation/ energy transfer in complex systems. SLs are hence very promising, both for facilitating new technologies, and for solving persistent issues faced by classical organics. However, current materials are critically limited by a need for supramolecular self-assembly. SL ensembles are formed, driven by interactions BETWEEN multiple molecules. Self-assembly is highly sensitive to changes in molecular structure, and dependent on both concentration and the local environment. This restricts predictable and reproducible processing and excludes SLs from applications where a low concentration/ discreet species is required.Here we aim to solve this longstanding limitation and propel SLs to the forefront. Firstly, systematic structural chemistry will afford robust design rules to construct Discreet Organic Superluminophores (DISCOS) that harness interactions WITHIN rigid molecules to enhance how they absorb and emit light, precluding self-assembly. Taking advantage of this fundamental advance, the DISCOS will next be broadly colour tuned to develop bespoke materials aimed at solving two of the most
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modelling of rheologically stratified granular flows by a multi-layer depth-averaged approach' in the context of a Horizon 2020 call.

assistant: **Objectives**

Geophysical granular flows, like rock avalanches and debris flows, represent a serious hazard to life and infrastructures in Europe. Yet their dynamics is still far from being completely understood. Recent experimental investigations on granular flows showed that velocity and solid volume fraction exhibit a stratified pattern along the flow depth. This indicates the superimposition of different rheological regimes. Moreover, non-local rheological theories have been recently proposed for capturing momentum exchanges, driven by the occurrence of force chains.The present multidisciplinary project aims at developing a computationally cost-effective multi-layer depth-averaged model for describing rheologically stratified granular flows. The model, having much lower computational costs than three-dimensional models, will be designed to capture the essential physics of granular flows in the depth-wise direction. To properly take into account the curvature effects due to basal topography, the model equations will be derived in curvilinear coordinates attached to the topography. Moreover, a suitable non-local constitutive law will be incorporated. The resulting equations will be numerically integrated by a proper finite volume scheme, taking into account their main mathematical properties, i.e. non-strict hyperbolicity and non-conservative form. The model validation will be carried out by using a wide experimental data set, previously gathered by the applicant on dry granular flows. The last stage of the project is devoted to extending the multi-layer approach to cases with dense interstitial fluid, so as to allow its application to debris flows.In line with H2020 priorities, especially as regards sustainable human settlements and their resilience to natural hazards due to clima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced intelligent medication - personalized drug dosage concepts to improve quality of life' (AIMED) under Sixth Framework.

assistant: **Objectives**

We plan to research and design electronic systems which can help identify the proper conditions under which to apply drug therapy (diagnosis) and which can set the dosage of the medication following objective effectiveness measures (therapy tracking and control).This electronically supported medication control will- Improve Quality of Life by enabling medication self-management- Improve the outcome of diseases by proper and timely reaction- Reduce mortality and hospitalization days by improving treatment standards- Reduce costs in the healthcare system by increasing efficiency and tracking quality of care.We plan research in two key areas:- A tele-care scenario for Heart Failure Medication Management and- An emergency tool for Stroke Type Differentiation. An existing research prototype body-worn ECG monitor will be further developed into a mobile system to be used by the Heart Failure patient.A telemetry solution for connection to the supervising clinic, and a distributed software to provide the clinical supervisors with enriched information will be a step to an autonomous medication management solution that needs only occasional checking and emergency attention, similar to an autopilot in aircraft. In a Stroke emergency outside a hospital, the haemorrhagic or ischemic cause cannot be determined. We propose to set up a prototypical system that could be further developed into a kit for ambulances.This will analyse the EEG and deliver a 3D map of the brain from high-resolution bioimpedance tomography signals of a Stroke patient to determine if thrombolysis is advisable because a vessel rupture can be ruled out. A trial will prove it's efficiency. We request 6 Marie Curie fellows in a total of 82 months over 3 years, with specialised medical experts (neurology and cardiolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Age-dependent mechanisms of sporadic Alzheimer’s Disease in patient-derived neurons' (AGEMEC).

assistant: **Concept**

Sporadic Alzheimer’s Disease (AD) accounts for the overwhelming majority of all AD cases and exclusively affects people at old age. However, mechanistic links between aging and AD pathology remain elusive. We recently discovered that in contrast to iPSC models, direct conversion of human fibroblasts into induced neurons (iNs) preserves signatures of aging, and we have started to develop a patient-based iN model system for AD. Our preliminary data suggests that AD iNs show a neuronal but de-differentiated transcriptome signature. In this project, we first combine cellular neuroscience assays and epigenetic landscape profiling to understand how neurons in AD fail to maintain their fully mature differentiated state, which might be key in permitting disease development. Next, using metabolome analysis including mass spec metabolite assessment, we explore a profound metabolic switch in AD iNs that shows surprisingly many aspects of aerobic glycolysis observed also in cancer. While this link might represent an interesting connection between two age-dependent and de-differentiation-associated diseases, it also opens new avenues to harness knowledge from the cancer field to better understand sporadic AD. We further focus on identifying and manipulating key metabolic regulators that appear to malfunction in an age-dependent manner, with the ultimate goal to define potential targets and treatment strategies. Finally, we will focus on early AD mechanisms by extending our model to mild cognitive impairment (MCI) patients. An agnostic transcriptome and epigenetic landscape approach of glutamatergic and serotonergic iNs will help to determine the earliest and probably most treatable disease mechanisms of AD, and to better understand the contribution of neuropsychiatric risk factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The development of a novel therapeutic vaccine for the selective treatment of the autoimmune disorder, Graves’ disease' (DAVIAD), addressing dissemination and exploitation.

assistant: **Impact**

This aim of the DAVIAD proposal is to develop a therapeutic vaccine for Graves’ disease (GD) that has a better safety and efficacy profile than current treatments. There is a high level of unmet need in the treatment of Graves’ disease especially in patients with Graves orbitopathy and children and adolescents (who generally suffer from the most chronic form of the disease). Autoimmune diseases arise as a consequence of a hypersensitive response to self antigens. This proposal focuses on the development of an antigen specific vaccine therapy to reinstate immune tolerance to Graves’ disease.  The selected peptides behave as apitopes (antigen processing independent epitopes) and bind to MHC class II molecules in the correct confirmation to induce tolerance. In the first instance DAVIAD will further characterise antigen specific peptides (based on the autoantigen associated with the disease) already selected using a validated discovery platform. DAVIAD will generate translational data to support a clinical trial application, conduct disease model studies and prepare the clinical trial application. DAVIAD will design and conduct a phase I/IIa trial in GD patients to show that efficacy and safety compare favourably with current treatments and those in development. The consortium has the expertise required to effectively and efficiently take the proposed vaccine through clinical development and eventual commercialisation. A disease modifying vaccine for GD will address a serious unmet need and potentially offer a therapy that can change the way this disease is treated, offering better quality of life for sufferers and reducing burden on health services.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Complex non-linear networks applied to modelling of district heating' (1994-1998).

assistant: **Concept**

Having spent a number of years in the field of district heating control, it has become apparent to the SME Proposer that the efficiency of these systems could be improved considerably. However, from experience they have learnt that this cannot be achieved with well-established technologies. A new technology which can provide a solution to this problem has been developed by InteSys Ltd, the Prime Proposer. This is the ISLEC Microchip, which has won twoS MART Awards from the UK Department of Trade and Industrv. The Microship can 'fingerprint' heat flow characteristics in and out of a building with a high degree of accuracy, and create a virtual equivalent of the buildinq inside the chip. This can be used to predict the heating needs of the building on an on-going basis. SMEs can use the ISLEC Microchip for development of more efficient control systems which perform control actions in advance, and thus save a lot more energy, in comparison with conventional control systems. It is thereforeproposed to investigate ISLEC-based solutions to the above problem. However, ISLEC cannot provide solutions to this problem in its existing form. Development of a network of ISLEC Microchips is required in order to carry out further research leading towards the solution of the problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Structure-Aware Geometry Processing'.

assistant: **Concept**

Geometric data is now ubiquitous. Such 3D content is either acquired using LiDAR scans, MRI scans, etc., or created using 3D modelers, or obtained as output of simulation processes. The data, however, come in low-level representations (e.g., points, polygons, voxel grids) and begets little understanding of the underlying objects or processes. This is unfortunate since such data have significant redundancies as they often measure related entities (e.g., humans in different poses, same room across multiple configurations, or chairs having different styles). While the data can potentially reveal significant self-similarities among objects and correlations across related objects, we are missing critically-needed tools for such analysis.Hence, I propose to develop mathematical frameworks and computational tools to extract, represent, manipulate, and utilize relations among 3D model collections. Essentially, I propose to factorize model collections into consistent structures (i.e., relations among parts in and across multiple objects) and low-dimensional variations, with local geometric details playing a subordinate role. Jointly analyzing model collections can further reveal relationshipsbetween form and their functions (e.g., chairs typically will have consistent back-seat relations, even if at the level of vertices the underlying models can be very different). This requires solving two coupled problems:(i) jointly analyzing large model collections to decouple consistent structure from dominant modes of variations, and (ii) using the information towards next generation form-finding possibilities.The grand goal is to lay the foundations of structure-aware geometry processing where computationally extracted geometric relations and constraints are automatically conformed to wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Pursuit of Wellness in Southeast Asia: New Encounters and Inequalities in an Emerging Industry', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

WELL-ASIA studies the commercialization of wellbeing as ‘wellness’ in twenty-first century Southeast Asia, a region with one of the fastest growing wellness industries in the world. People from within and beyond Asia are travelling more than ever before in search of yoga, meditation and spa retreats, detoxifying diets, anti-ageing therapies, and emotionally-healing experiences. This growing interest in wellness takes shape in the context of increasing anxiety, longevity in a rapidly ageing world, and a growing global middle-class. WELL-ASIA examines the people and places involved in producing, sustaining, and contesting the idea of wellness in contemporary Asia. The project asks: What social, economic and moral transformations, and what new patterns of inequality does the pursuit of wellness generate? How are diverse interests brought into tension and negotiated in the transnational encounters between (i) those who labour in the industry, (ii) the travellers who consume its services, and (iii) the local communities involved? Situated in Southeast Asia, where multiple healing traditions circulate transnationally, often with deep historical roots, this multi-sited ethnographic study focusses on three sites that exhibit both the diversity and distinctiveness of wellness in the region: Singapore, Chiang Mai, and Ubud. The project will involve an interdisciplinary team working in the fields of social anthropology, political and economic geography, media and cultural studies. WELL-ASIA contends that the expansion of commercial wellness is unevenly transforming local economies, reconfiguring transnational mobilities, and bringing to light emergent, highly mobile, and marketable visions of what it means to be well in a hyper-capitalist and interconnected world, in ways that tra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Continuous real-time monitoring of water toxicity'.

assistant: **Concept**

Urban centres, industries and agriculture produce large volumes of wastewater; in addition, the current population growth, accelerated urbanization and economic development are increasing the quantity and pollution of wastewater globally. Being a by-product of human activities, wastewater contains chemical, biological and physical pollutants, so it must be treated to remove all contaminants before it is released in the environment. Releasing untreated or inadequately treated wastewater is dangerous and has harmful effects on human health, the environment, and economic activities.Water quality after wastewater purification varies over time, even and especially during one single day, but managers do not have the necessary tools to monitor these variations. Currently available methods based on bioassays or physical and chemical parameters require sampling, conservation and transport, and are based on spot-sampling (1-2 times/year). These methods are not able to provide information on temporal variability and have low efficiency, durability, and specificity; they are also slow in providing results (at least 72 hours) and can’t allow real time monitoring. To overcome these limitations, ViewPoint has developed ToxMate: a tool for the automated real-time, on-site and on-line monitoring of wastewater toxicity. It is based on the simultaneous analysis of the locomotor behaviour of 3 different species of aquatic invertebrates and it uses infrared light and powerful and precise cameras to record continuously the activity of the animals. The system is composed of 3 panels, each containing 16 animals, so 48 animals can be analysed at the same time and for up to 30 days. ToxMate is fast: it can provide a result on water toxicity in just one hour, so it allows public authorities and w