RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Role of autonomous B cell receptor signalling and external antigen in the pathogenesis of chronic lymphocytic leukaemia (CLL)' to be submitted under Horizon 2020.

assistant: **Abstract**

The proposed project aims at investigating the molecular mechanisms that activate B cell antigen receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL). While it is widely accepted that the unbroken BCR expression in CLL cells is indicative for a key role in disease development, the mechanisms that induce BCR activation and survival of malignant cells are still elusive. Using a unique reconstitution system, we have recently shown that CLL-derived BCRs possess the exceptional capacity for cell-autonomous signalling independent of external antigen. Crystallographic analyses confirmed our model that CLL-BCRs bind to intrinsic motifs in nearby BCRs on the very same cell. In addition to the BCR, several pathogenic factors influence the biological behaviour of CLL cells, but the functional hierarchy and the effect on BCR signalling are insufficiently understood. Here, we aim at investigating the structural cause of autonomous signalling as well as the characterization of important signalling pathways and their mechanistic action in CLL pathogenesis. By combining crystallography with the measurement of autonomous signalling of wild type and mutated receptors in our unique reconstitution system, we will generate a structure-function relationship for CLL-BCRs. By generating new animal models and by employing classical as well as cutting-edge approaches of biochemistry and molecular/cellular immunology, we will comprehensively characterize the signalling pathways that are activated by autonomous signalling and might be important for CLL pathogenesis.These systematic efforts are necessary to understand how various biological mechanisms operate and ultimately activate downstream pathways that result in a lymphoproliferative disease. In addition, a cohesive model of CLL pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Statistical theory and methodology for the combination of heterogeneous and distributed data'.

assistant: **Innovation**

Data is now collected at unprecedented scales across many industries, meaning that there is huge potential for evidence-based advances in science, technology and public policy. However, to harness this potential we must navigate repositories that are often a far cry from the idealised datasets, carefully collected and curated under perfect conditions, that are usually imagined when new statistical methodology is introduced. Data are often gathered quickly and cheaply, patched together from multiple locations, with limited regard to enforcing experimental standards. We may have the large sample sizes we desire, but there will be missing values, misaligned datasets, contamination and, depending on the sector, there may be noise added purposefully to satisfy individuals' and regulatory bodies' privacy concerns.We propose to address such difficulties through the development of new statistical methodology and theoretical frameworks that explicitly incorporate various forms of data heterogeneity and measurement error. This will be divided into four main areas:1. Accounting for sampling bias when a complete dataset is complemented by additional incomplete datasets. This will be studied through the lens of semiparametric theory for functional estimation.2. Combining two or more datasets that record overlapping but distinct sets of variables, where few or no complete records of all variables are available. These file matching problems will be studied using new developments in statistical optimal transport.3. Examining the effect of the violation of missing data assumptions. Here we will introduce techniques from robust statistics to mitigate the error due to misspecifying assumptions about sampling bias.4. Securing individuals' private data through the intentional use of noisy m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synthetic Cellular Signaling Circuits' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cellular signaling systems are crucially important for a broad range of critical health and disease areas and high value industrial applications. Signaling systems are the target for more than half of the medicines marketed by the pharmaceutical industry, and form the main R&D area for the nutrition, flavour and fragrance industries. SynSignal is a multidisciplinary high-tech consortium working in synthetic biology's area of greatest untapped potential, delivering a synthetic biology toolbox and finished products custom designed for major present and future industrial applications of cellular signaling. Based on the leading expertise and innovative drive of the partners, SynSignal will address this urgent and imposing bottleneck, by providing new and sophisticated synthetic biology tools and technologies to overcome the challenges currently facing signaling-based product development. Putting in place the technological innovations, toolboxes, and application-focused materials created during SynSignal will have a dramatic impact on the accessibility of drug discovery technologies, particularly for cancer and diabetes, and for enabling technologies to create the next generation of flavours, fragrances, and nutritional ingredients. Our innovations will provide immediate benefits to the health and well-being of Europe’s citizens and to the competitiveness of key European industries alike, and catalyze their transition towards sustainable production principles. In addition, all partners in SynSignal themselves will draw great benefit from the activities proposed. Private sector partners will considerably enhance their discovery and technology platforms, thereby increasing their efficiency, output and valuation. Academic partners in SynSignal will decisively advance fundamenta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Armoring multifunctional T cells for cancer therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Adoptive T cell therapy (ACT) is a powerful approach to treat even advanced cancer diseases where poor prognosis calls for innovative treatments. However ACT is critically limited by insufficient T cell infiltration into the tumor, T cell activation at the tumor site and local T cell suppression. Few advances have been made in the field to tackle these limitations besides increasing T cell activation. My group has focussed on these unaddressed issues but came to realise that tackling these one by one will not be sufficient. I have developed a panel of unpublished chemokine receptors and innovative modular antibody-activated receptors which have the potential to overcome the limitations of ACT against solid tumors. This ground-breaking portfolio places my group in the unique position to address combination of synergistic receptors and enable cellular therapies in previously unsuccessful indications. My project will provide the rationale for provision of an effective cancer treatment. The goal is to develop the next generation of ACT through T cell engineering both by forced expression of migratory and activating receptors and simultaneous deletion of immune suppressive molecules by gene editing. ARMOR-T will provide the basis for further preclinical and clinical development of a pioneering cellular product devoid of the limitations of available products to date. I will prove 1) synergy between migratory and modular activating receptors, 2) feasibility to integrate gene editing into a T cell expansion protocol, 3) synergy between gene editing, migratory and modular receptors and 4) efficacy, safety and mode of action. The main work of the project will be carried out in models of pancreatic cancer. The ARMOR-T platform will subsequently be translated to other cancer entiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regular Arrays of Artificial Surface-Mounted Dipolar Molecular Rotors' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

We propose a feasibility demonstration of an unprecedented concept: preparation of regular two-dimensional arrays of artificial surface-mounted dipolar molecular rotors and control of their coherent motion by the application of an outside electric field.  The proposal involves a highly interdisciplinary endeavor, which requires experience in synthesis (preparation of molecular rotors), surface chemistry (assembly of rotors into arrays on surfaces), surface spectroscopy and scanning microscopy (characterization of rotor arrays on surfaces), and theory (modeling of rotor dynamics).  The principal investigator is presently actively working and publishing in all of these subdisciplines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Industrial Modular Battery Pack Concept Addressing High Energy Density, Environmental Friendliness, Flexibility and Cost Efficiency for Automotive Applications' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

iModBatt stands for Industrial Modular Battery Pack Concept Addressing High Energy Density, Environmental Friendliness, Flexibility and Cost Efficiency for Automotive Applications. The aim of iModBatt is to design and manufacture, with minimum environmental impact, a high energy density modular battery pack flexible enough to be used in automotive and small stationary applications. This battery pack will be suitable for industrial automated assembly with an easy disassembly design, to make possible the shift from primary applications to secondary ones, and to facilitate the pack recyclability or parts replacement if necessary. The project concept is built around an already existing technologically breakthrough, modular battery pack design primarily developed for specialty applications, that has proven excellent performance and cost efficiency in such a manner that higher ambition, wider spread electric vehicle applications seem the natural next developmental step for such a concept.The project focuses into maximization of the energy density of a lithium ion pack through the optimization of the structural design and components of a battery pack for a given cell form factor. In this sense the strategy is to increase the energy density by reducing the weight of the battery pack while keeping structural integrity and easy assembly and manufacturing. Chemistry and BMS work is beyond the scope of the project, which focuses in the structural design and manufacturing.The Consortium includes industrial partners of every step of the battery pack value chain, including  automotive OEMs, battery parts manufacturers as well as leading European research centres with ample experience in the field of batteries.


**Keywords:** Modular battery pack, breakthrough, design, manufacturing,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'High quality clothes made from marine plastic litter' (UPCYCLINGTHEOCEANS) targeting Horizon 2020.

assistant: **Abstract**

ECOALF is an SME that design and market high quality textile products and accessories made of recycled materials (bottles, fishing nests, tyres, coffee, cotton…).The main objective of the UPCYCLING THE OCEANS project is to produce and sell fabrics and clothes made from marine plastic litter, by recycling and industrial methods to convert these plastics into high properties textiles. European seas contain many tons of waste, mainly plastic (around 400 kg per km2). This plastic litter has a very negative impact in the marine environment even affecting the food chain (potentially triggering endocrine and/or carcinogenic processes).To contribute to mitigate this problem ECOALF proposes to implement a collaborative scheme with fishermen’s organisations (agreements already signed) to collect plastic from seas; to implement an industrial process that includes waste management, pellets production and additivation, spinning and fabrics, and clothes manufacturing; and to distributions and marketing the new products in Europe.To that end ECOALF proposes a feasibility study:-To analyse the economic feasibility of the initiative (production cost, volume of sales, incomes; relevant economic indicators; sensitive analysis).-To identify logistical needs to obtain the marine plastic litter and to establish a mechanism to provide the consumer with a reliable Guarantee of Origin (GoO) that reflects that the clothes are made 100% from plastic waste and which percentage is from marine origin.-To ensure the technical feasibility to additivate properly the flakes to obtain pellets that fulfill with ECOALF fabrics requirements. To define the adequate terrestrial / marine mix to ensure stability during the sinning process.-To carry out a survey among clients and distributors to assess the marke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Consolidation of scientific technological expertise to assess the reliability of reactor pressure vessel embrittlement prediction in particular for the arctic area plant' under Fifth Framework.

assistant: **Concept**

Kola Nuclear Power Plant is located in the Arctic area of Russia near the town of Polaner Sorry. The key component of NPP is the Reactor Pressure Vessel (RPV). The evaluation and prognosis of RPV ernbrittlement and the allowable period of its safe operation are performed on the basis of impact test results on irradiated surveillance specimens (SS) . However the results of SS testing are not fully representative. The key issue is the difference between the irradiation temperature of the SS and the actual RPV component temperature. The main OBJECTIVE of this project is: The consolidation of Western and Eastern scientific and technological practice to implement modern methods for SS irradiation temperature measurement in order to improve the reliability of RPV ernbrittlement prediction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Plasticity in the Shoot Branching Regulatory Network' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Plants can modulate their developmental program depending on environmental conditions, such as nutrient availability and levels and quality of light. A single plant genotype is able to give rise to a wide range of phenotypes. Despite the relevant ecological and evolutionary consequences of this plasticity, very little is known about its molecular basis. A good example of developmental plasticity is the degree of shoot branching. Our knowledge of the control of branching has advanced sufficiently, providing the necessary intellectual framework to investigate more complex properties such as plasticity in the regulatory system. Therefore, the host laboratory examined multiple quantitatively different versions of this regulatory network, which resulted in the identification of Quantitative Trait Loci (QTLs) for branch number and branch number plasticity. In this project, the genes that underlie these QTLs will be identified and characterised. This QTL study may result in the identification of new genes involved in the regulation of shoot branching, but could also reveal allelic variation at known loci. It is possible that these genes affect both branch number and branching plasticity. Alternatively, these genes might be specifically involved in plasticity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The first high-precision Computer-Controlled Collarbone Cutter for Whitefish', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Our company, CURIO ltd., founded in 2007, is one of the Icelandic leading developers and manufacturers of fish processing machinery. With a team of 40 people, we design, produce, and commercialize three types of high performance fish processing machines (i.e. heading, filleting, and skinning), and a reference of knife sharpening. Currently, we sale our machinery to over 100 of the main fish processing companies worldwide.  This close contact with the fish processing industry enabled us to identify a new market niche to be exploited: Inefficient practices and lack of specialized machinery during fish processing (more specifically during collarbone cutting), which translate in the underutilization or even wastage of tons of fish meat every day. In this sense, and given our commitment with fish processing optimization, we developed 4CWhite: the first computer controlled fish processing machine designed to cut the collarbone of different de-headed whitefish species. In this way, 4CWhite will increase the loin yield up to 2% to be profitable in further processing, in comparison with current alternatives (i.e. mainly manually cutting or by in-house adapted heading machines) that represent a loin wastage up to 8%. 4CWhite’s productivity (20,000 fish/day), extended service life (>15 years), reduced labour requirements (only one operator) demonstrate that it is the best value for money solution to increase the efficiency of this step of fish processing and promote a more sustainable use of oceans resources.  Based on 4CWhite sales on demand among the major whitefish processors from Nordic and North-western European countries, we expect to sell at least 200 4CWhite units by 2022, reaching a market share around 8%. Our financial figures forecast €58 million of cumulative revenues
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Very high resolution real-time graphic interaction for the mediaIndustries' under Fifth Framework.

assistant: **Concept**

Speed-FX has produced the first European 'personal supercomputer' designed for the digital film and media industries. The first implementation (which was publicly launched at NAB in Las Vegas, 18-21 April 2004), combines 8 dual-processor 'nodes', capable of processing, manipulating, combining and display in real time multiple moving image streams of 2048 x 1556 pixels (2K) or single streams of 4096 x 3112 pixels (4K), handling data streams of 1.6 Gigabytes/second at 4K. It is easily expandable to configurations with a bandwidth in excess of 6Gigabytes/second and 200 Gflops/second.. The hardware architecture employs a host together with a cluster of 4 to up to 32 nodes, each comprising a standard twin-processor PC, graphics card and RAID drives combined in a novel way that overcomes the well-known limitations of the standard PC (or PC cluster) with its i/o data bottlenecks for disks, network and graphics. The Speed-FX architecture 'stripes' the image data stream, so that each 'node' of the cluster processes a fraction of the frame (1/4 in a four-node system, 1/16th in a 16-node model). In this way, each PC processes an amount of data equivalent to standard definition video, while the system as a whole operates on the large image sizes required by the motion picture industry.To make this possible, a parallel processing framework with a simple application programming interface (API) had to be developed, a parallel file system driver and a novel means of combining and synchronising the image 'stripes' from standard graphics cards. Two patent applications relating to the video combiner have been filed. The video combiner allows the dynamic display of multiple windows with independent zoom utilising standard graphics card capability despite separation of the image into stripe