RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An Integrative Model for Nuclear Receptor Signaling: towards understanding of NR signaling in health and disease' under Seventh Framework.

assistant: **Concept**

Nuclear receptors (NR) are transcription factors activated by nuclear hormones, dietary components and xenobiotics. Nucleo-cytoplasmic shuttling is an important part of NR signalling: NR nucleo-cytoplasmic shuttling is regulated by external NR ligands and different intra-cellular processes.In close collaboration with experimental groups within the Marie Curie RTN NucSys (Sept 2007-Sept 2009) we have build a mechanism based kinetic model, integrating nucleo-cytoplasmic shuttling and signalling processes. This model was created for one class of nuclear receptors, i.e.,  steroid hormone receptors, and is presently used for systems biological studies of the role of nucleo-cytoplasmic shuttling in steroid hormone receptor signalling. However, other groups of nuclear receptors have similar network structures.  We here propose that the steroid hormone receptor signalling model can be used as canonical model and re-parameterised so as to become relevant for any of the most important nuclear receptor groups.In the project proposed in this application for a European Reintegration Grant, the canonical model of NR signalling will be adapted to several most important classes of nuclear receptors.Then, models of different nuclear receptor signalling pathways will be integrated in a bigger NR Signalling Integrative Model in order to begin to study the role of the entire network in health and disease.  In particular, the research will be focused on the process of integration of different signals impinging the same NR signalling pathway and on crosstalk between different NRs. Taking into account the crucial role of both phenomena in the development of aging-related syndromes and many systems diseases such as cancer and osteoporosis, we anticipate substantial biomedical relevance of our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Observations and Modelling of Eddy Scale Geostrophic and Ageostrophic Circulation' in the context of a Fourth Framework call.

assistant: **Objectives**

OMEGA has three main objectives; to determine the three-dimensional ageostrophic circulation at mesoscale (10-100 km) fronts and eddies and quantitatively estimate the vertical velocity, to evaluate the impact of the ageostrophic vertical motion on the biogeochemical properties in the upper 400 m, and to provide the scientific community with a standardised tool for the computation of vertical motions from routine CTD and ADCP data. Vertical motion couples the deep ocean with the near surface layers, providing an enhanced transport route for heat, nutrients and biomass. The distribution of primary production patchiness is driven by mesoscale physics. At these scales, successful research requires interdisciplinary observational strategies OMEGA is a comprehensive proposal combining an observational strategy of remote sensing and in-situ high resolution physical, biological and meteorological measurement with a numerical modelling/data assimilation strategy to quantify the errors involved in the diagnostic analysis of the observational data and make prognostic simulations of mesoscale features. Mesoscale eddies are ubiquitous in the ocean and the conclusions from OMEGA will be relevant to all ocean regions. However, the Alboran Sea and Almeria-Oran Front have been selected as the experimental area because of favourable environmental conditions and convenience for EC member countries. No one country or organisation could undertake OMEGA on its own. The expertise of the 7 organisations from 5 EC countries making this proposal is ideally suited to the multi-disciplinary research collaboration proposed. OMEGA brings together recent research under nationally funded projects at all of the organisations involved as partners or named subcontractors. Several of the research scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of a novel Ca2+ signalling system and functional identification of early-immediate genes in plant immunity' to be submitted under Sixth Framework.

assistant: **Abstract**

In the immune response, a resistance protein from the host (R) recognizes an avirulent protein from the pathogen (Avr) and elicits a defence response that abrogates the infection attempt. The immune response is generally accompanied by the hypersensitive response (HR), a form of programmed cell death (PCD) that manifests within hours after R/Avr recognition. In a random Virus-Induced-Gene-Silencing (VIGS) screening of a Nicotiana benthamiana cDNA library, I identified several genes that participate in the HR. Among those genes, I characterized in detail a MAPK kinase kinase kinase (MAPKKKa), a positive regulator of cell death in inmunity and susceptibility. I also identified a calcineurin B-like protein (NbCBL) and its target, a CBL-interacting protein kinase (NbCIPK).These results implicate for the first time members of the CBL and CIPK families in biotic stress signalling. As a short-term goal, this project will focus on the characterization of NbCBL and NbCIPK in the immune and susceptible responses to pathogens in Solanaceae and Arabidopsis. For this purpose, I will use functional, biochemical, sub-cellular localization and genetic approaches. I will also investigate if there is a connection between the phosphorylation cascades elicited by CBL-CIPK and MA PKKKa. As a mid-long term goal, I plan to establish an optimised Forward Functional Genomics Screening strategy aimed to the targeted identification of genes that participate in early signalling events in the immune response (between R/Avr and MAPKKKa).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Muon campus in US and Europe contribution' (MUSE), addressing dissemination and exploitation.

assistant: **Impact**

The Muon Campus at FNAL, USA, will host in the next few years two world class experiments dedicated to the search for signals of new physics. Muon g-2 will determine with unprecedented precision the anomalous magnetic moment of the muon while Mu2e will improve by four orders of magnitude the sensitivity on the search for the as-yet unobserved Charged Lepton Flavour Violating process of a neutrinoless conversion of a muon to an electron. European research institutions have a leading role in both detector development and construction and in the calibration and analysis of the data. The results from the FNAL experiments will complement those from similar CLFV searches being carried out in Europe and will produce very fruitful collaborations in this field. Through an involvement in both the US and the European programmes European institutes will be at the forefront of the search for evidence of new physics in the muon sector.The goal of this proposal is to establish new collaborations among European groups participating in the Muon Campus activities and to strengthen the already existing partnership with FNAL. State-of-the-art detectors will be designed, built, commissioned. The Mu2e crystal calorimeter will provide unprecedented timing performance for low energy electrons in the presence of a strong magnetic field exploiting solid state photosensors and the Mu2e high-purity germanium detector will record X-rays at rates and in radiation levels surpassing previous experiments. The Muon g-2 straw-tracking system will measure the muon beam profile with an accuracy in the vertical plane of better than 10 mrad and will efficiently identify pileup and lost-muon events. A laser monitor system will be a common effort of the two experiments, with the need for Muon g-2 to reach an a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of methodologies in order to measure the migration of non-phthalate compounds from pvc plasticised articles'.

assistant: **Concept**

Plasticiser are substances mainly used in softening PVC. The use of such substances, specially, phthalates, in PVC toys intended to be put into the mouth for children under three has produced a great controversy and confronted opinions. Phthalates have been banned in toys for children under three intended to be put into the mouth (Decision of the Commission of 7 December 1999) and one of the reasons for that was the lack of a method for measuring the amount of phthalate migrated. Most of manufacturers have changed the plasticisers in their products so methods in order to determine the amount of plasticiser migrated from a soft PVC article are necessary, specially when the article is a toy product. A lot of factors must be considered when developing a method for migration. Sample preparation is one of the most important and careful optimization must be done with these factors. This is the aim of this proposal, also including a validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Primordial Germ Cells Environmentally-driven fate in Zebrafish'.

assistant: **Objectives**

In a global climate change scenario with pieces of evidence of abiotic factor changes and the increase of pollutants due to anthropogenic activities, we are starting to accumulate evidence of its effects on animal welfare and physiology. One of these effects is changes in fish sex determination and differentiation processes due to alterations of abiotic and anthropogenic factors. Among these factors, temperature is known to affect sex determination well before the gonads are differentiated, pointing towards an evident interplay between the genetic and environmental factors, even prior to gonad formation at the primordial germ cell (PGCs) stage. However, how temperature controls PGCs and final sex ratios fate is still unknown. In this project, I aim to dissect when and how temperature is controlling the fate of PGCs. Hence, driving the future sex ratio of the population since changes in sex ratios could put at risk future food production and species conservation. To that extent, I propose combining state-of-the-art imaging, genomic, and epigenetic technologies to analyse PGCs transcriptomic and epigenetic landscapes of zebrafish under thermal stress. This project capitalises on combining my background in epigenetics and bioinformatic fields with extensive expertise in developmental biology, fish sex determination and differentiation and spatial transcriptomics of the host labs. This multidisciplinary proposal will explain how temperature increases as predicted on a climate change scenario modulates PGCs fate and identity. These results will significantly advance the field of epigenetics and developmental biology and will impact future food production and species conservation. Finally, the knowledge and skills gained from this project will allow me to become an independen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Deep learning for mammography: Improving accuracy and productivity in breast cancer diagnosis.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Breast cancer is one of the main causes of death among women worldwide. Early diagnosis by mammography scanning is the best way to prevent mortality, but it requires the intervention of a highly trained workforce (radiologists). While the demand for radiologists is on the rise, the supply is quickly diminishing worldwide. This leads to long waiting lists and delays in getting a diagnosis, negatively affecting quality of services and ultimately survival rates. There is a strong need for tools that help radiologists make accurate decisions on mammography images in less time. CAD-based systems were developed to address this need; however, they have very low specificity, which leads to a high number of false positives, unnecessarily increasing the recall rates, and raising doubts about their usefulness. Mammo1 will be a game-changer in the area of breast cancer diagnosis by applying ground-breaking machine learning techniques, which are able to outperform all the currently marketed CAD-based solutions and even single radiologists.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'REGULATION OF TRANSCRIPTION' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

During the first step of gene expression, RNA Polymerase (RNAP) transcribes RNA from a DNA template in every living cell. Crystal structures of RNAP core as well as RNAP elongation complexes (ECs) have revolutionized our understanding of transcription. This groundwork paved the way for more complex questions addressing the regulation of transcription. Because of its fundamental role, transcriptional regulation has an impact on every aspect of biology including a growing list of human diseases. Thus, a detailed and mechanistic understanding is crucial and this is the area where the work proposed here will contribute. A combination of biochemistry and structural approaches (primarily X-ray crystallography) will be used to gain detailed understanding on the regulation of transcription by protein factors and non-coding RNAs. To complement the structural and biochemical results, Fluorescence Resonance Energy Transfer (FRET) studies will be used to study the dynamics of RNAP during processes that regulate transcription such as transcriptional pausing. The FRET assay will also be used to test hypotheses regarding the recognition of errors made by RNA polymerase.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Behavioural and physiological markers of Parental Embodied Mentalising: Cultural, gender, and attachment factors' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

parental mentalising, the parent’s capacity to regard the child as a psychological agent (Sharp & Fonagy, 2008), is an important factor predicting attachment security (e.g., Slade et al., 2004).Thus far, all formulations of parental mentalising conceptualise and measure it as verbal, explicit, and reflective capacity (e.g. Meins, 1999; Slade, 2002).Despite their empirical contribution, these approaches are limited in their ability to illuminate the process through which parental mental capacities actually shape the child’s representation of their relationship in terms of attachment security. Shai and Belsky (2011a, b) recently introduced the construct and measure of parental embodied mentalising (PEM), an implicit, body-based, and interactive approach to parental mentalising. A study of 150 mothers interacting with their 6-months-old infants found that the parent’s PEM profile not only predicted the child’s attachment at 15 months over and above established maternal sensitivity measures, but that once PEM variables were accounted for maternal sensitivity was no longer predicted attachment (Shai & Belsky, submitted). However exciting and promising these findings are, they are preliminary and call for further investigation. Using multiple cutting-edge methods, including psychophysiological, behavioural, and self-reports this research scrutinizes four questions: 1) Can PEM be cross-culturally validated such that maternal PEM in an Israeli sample will predict attachment security as in the American sample? 2) What are the behavioural similarities and differences between paternal and maternal PEM? 3) What are the links between behavioural and psychophysiological measures of PEM? 4) How does adult attachment associate with PEM and with child attachment security? This research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Inkjet-Printed Wireless Powered Circuits for Sensing and Identification.'.

assistant: **Innovation**

The project establishes the application of inkjet printing as a key technology for the implementation of batteryless and wireless sensor and communication circuits based on wireless power transfer and energy harvesting, enabling the realization of the Internet of Things (IoT). Inkjet printing supports a large volume production, achieves a good resolution necessary for high frequency electronics, enables the use of a variety of low cost and flexible materials, and is a direct-write, and additive manufacturing technology. The research outcomes of the project focus in two goals, 1) demonstrate low profile, conformal, inkjet printed RF energy harvesters and autonomous wireless sensor and communication circuits, and 2) establish inkjet printing in millimeter wave frequencies. The applicant will become an expert in inkjet printing during the outgoing phase at Georgia Tech ATHENA laboratory, a world leading laboratory in inkjet printed RF electronics, where he would gain hands-on training in the technology, and he will develop transferable skills related to proposal, IPR and outreach activities and a wide scientific and industrial network of contacts. The applicant will also transfer to ATHENA lab his broad experience in energy harvesting and nonlinear circuit design, and he will enable a link with European networks in the field such as EU COST IC1301 on wireless power transfer, and foster a long-term collaboration beyond the project. Upon his return, an industrial secondment is foreseen which will allow the applicant to further train on IPR, as well as familiarize himself with the process of bringing the outcomes of the project into commercial products. The applicant will participate in the Scientific coordination and lead the Microwave Systems and Nanotechnology Group of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Freestanding energy-to-Hydrogen fuel by water splitting using Earth-abundant materials in a novel, eco-friendly, sustainable and scalable photoelectrochemical Cell system', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The FreeHydroCells project aims to create a new photoelectrochemical system capable of clean, efficient solar-to-chemical energy conversion, with hydrogen gas storing the chemical energy. The system would mimic the solar-energy absorption potential of a leaf by arraying cascades of nanometre thick semiconducting materials as buried pn-junctions that, when submerged in water and exposed to sunlight, are capable of freestanding photoelectrochemical water splitting. A number of technological challenges restrict the cost-effective efficiency of clean, green, solar-to-chemical hydrogen, state-of-the-art systems, making it commercially unattractive, and severely limiting hydrogens role in decarbonisation. However, the FreeHydroCells project proposes to leverage a number of advancements in thin film materials, devices, and processes to make similar breakthroughs in photoelectrochemical band-engineering for interconnected bands, defect minimisation, thin film thickness uniformity continuity to minimise drift-dominated transit times, carrier doping for high conductivity, carrier type selectivity and, importantly, preventing significant recombination of light-generated carriers by ensuring drift transport under multiple in-built electric fields. These breakthroughs would transform the transfer efficiency of solar-to-chemical energy via the carefully aligned redox potential and propel the photoelectrochemical water splitting reactions to morph solar energy into hydrogen bonds. The new materials system could be cost-effectively realised through modified delivery techniques of atomic layer deposition and chemical vapour deposition in manufacturing-compatible, large-area capable, equipment that is now common in commercial chip and solar cell processing technologies. FreeHydroCells mu