RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Impact of Political and Climate Change on Women’s Agency: A Social Power Analysis for the Late 3rd Millennium BCE Egypt' (IPOCCWWA) under Horizon Europe.

assistant: **Objectives**

A detailed social history of the women from Egypt’s First Intermediate Period (FIP) needs to be added to the growing corpus of women’s historical narratives. This pivotal period of Egyptian history, the late third millennium BCE, witnessed profound transformations to their social and political structures. These dramatic changes arose from political disintegration and the effects of environmental stresses from climate change at the end of the preceding Old Kingdom period (OK). While the FIP has received broad study, dedicated research into the women from this period has yet to be conducted. Historically, FIP women’s data, derived primarily from biographical inscriptions that sometimes detail their involvement in economic, political, or religious roles (titles), have been subsumed into female title studies of the OK period or discussed in conjunction with the women of the following Middle Kingdom (MK) period. Existing scholarship centres on biographies of exceptional women or significant inscriptions, and women’s details appear more generally in wide-ranging compilations of this historical period. Yet, owing to the unique archaeological and epigraphical evidence of the FIP, it offers the opportunity to examine a broader cross-section of the female population, including levels of society previously absent in other periods. For the first time, the women of the FIP and their agencies will be analysed via a theoretical framework that analyses social power based on the women’s roles and their access to/control over economic, symbolic, and/or political resources. Thus, the objective of this project, The Impact of Political and Climate Change on Women’s Agency: A Social Power Analysis (IPOCCWWA), is to produce a quantitative and qualitative account of the women of the FIP indepe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fostering capacity building for civic resilience and participation: Dialogic communication ethics and accountability' (DIACOMET) under Horizon Europe.

assistant: **Objectives**

Digital communication enormously expands the number of ways people can interact and engage, but also challenges European societies by spread of conflict instigation, hate speech, and increasing amount of disinformation. The many initiators of destructive communication acts are various actors with diverse interests, who are not bound by either professional or ethical rules or obligations to distribute truthful information or stand for its reliability. The existing framework of public communication does not empower citizens to influence the ways the media institutions and actors operate in European democracies.DIACOMET contributes to the advancement of ethical and accountable communication by fostering capacity building for civic resilience against information distortions and promoting civic accountability. Therefore, DIACOMET aims to generate a concept of dialogic communication ethics (DCE), which would provide a framework for an inclusive model of accountability mechanisms that combine media accountability (the level of organisations) with civic accountability (the level of citizens) and is guided by a Civic Code of Good Communication Conduct (CGC) (a new type of code of communication ethics).The DIACOMET proposal explicitly addresses the aims of the Horizon Europe Culture, creativity and inclusive society Work Programme, the Topic, the Call and the European Democracy Action Plan through:1. Analysis of the role of dialogic communication in existing ethics codes and guidelines and formulation of the CGC.2. A novel concept of inclusive civic accountability bodies and a tested accountability mechanism.3. An interactive ‘dilemma game’ and a forum for learning and discussion.DIACOMET proposes to establish a European network of civic accountability bodies for supporting indiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SLAMF7-CAR T cells prepared by Sleeping Beauty gene-transfer for immunotherapy of multiple myeloma – a rare hematologic disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

CARAMBA is proposing to use the revolutionary CAR-T cell technology to tackle multiple myeloma, a rare and incurable hematologic malignancy. Myeloma is associated with a substantial socioeconomic burden and there is a strong demand by patients, their families and caregivers for a curative myeloma treatment. The CARAMBA investigators will conduct a phase I/II clinical trial of immunotherapy with patient-derived T cells that are engineered to express a synthetic chimeric antigen receptor (CAR) specific for the myeloma antigen SLAMF7. SLAMF7 is uniformly expressed on all myeloma cells in every patient, and SLAMF7 CAR-T cells will be equally effective in women and men. The efficacy and safety of SLAMF7 CAR-T cells has been validated by the coordinator in comprehensive pre-clinical testing which highlighted their unprecedented curative potential. SLAMF7 CAR-T cells have received an orphan designation for the indication multiple myeloma by the EC. The successful conduct, rapid and complete recruitment into the clinical trial is ensured by participation of 4 clinical myeloma centres of excellence in 4 EU member states, and the largest myeloma patient advocacy group in Europe, MPE. The SME partners in CARAMBA are prepared to develop the SLAMF7 CAR product all the way to market authorization. CAR-T cell therapy has been recognized as a ‘Breakthrough Therapy’ and clinical proof-of-concept obtained with CD19 CAR-T cells in leukemia and lymphoma. CARAMBA is building on novel and proprietary, cutting-edge CAR technologies including virus-free Sleeping Beauty CAR gene-transfer from DNA minicircles which substantially reduces the cost of CAR-T cell manufacturing, making it an economically viable and sustainable medicinal product. We are confident, that if funded, CARAMBA will accompli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EUROPTOSIS' to be submitted under Sixth Framework.

assistant: **Abstract**

The European Cell Death Organization (ECDO) was founded in 1994 and its members represent all major cell death research groups in Europe. The main aims of the ECDO are to share information on current developments in the cell death research field and to fac ilitate scientific links between participating laboratories. Therfore, ECDO applies for European financial support for the organization of a series of annual high-level scientific meetings, workshops and basic courses focussing on cell death research. Stim ulation of cell death research is of great importance for the European community since deregulation of cell death contributes to many diseases such as cancer, degenerative disorders, inflammation, etc. A better understanding of the molecular fundamentals o f cell death can lead to therapeutic improvement of several diseases. ECDO has organized before annual Euroconferences on apoptosis", special workshops and courses for young researchers. The European School of Hematology and ECDO jointly organized the fir st seven Meetings with financial support of the European Community. From the eighth Meeting ECDO is the only organizer of the Euroconferences. The annual "Euroconferences on apoptosis" have an excellent scientific reputation and aim to bring together mainl y meetings attract many early-stage researchers since there is ample time scheduled in the programs to present their data both by means of oral presentations and poster sessions. During these sessions there is a lot of discussion between established and ju nior researchers, contributing to scientific training of young researchers. In addition, it is our experience that by bringing together the European cell death research community many long-standing collaborations arise, contributing to the aim of creating a s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Local Control of Macroscopic Properties in Isolated Many-body Quantum Systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Studies of many-body quantum systems in the last century have been mainly focussed on equilibrium properties; the systems of interest were typically coupled to an environment, which brings about relaxation after short times. The situation changed with the advent of experiments on clouds of ultra-cold, trapped atoms. These are by design almost isolated, and allow for investigations into nonequilibrium dynamics before the onset of dissipative processes. The characterization of such dynamics is now a main frontier of theoretical physics. One of the most exciting phenomena observed was the emergence of a new kind of relaxation, not caused by dissipation. The system acts as its own bath and at late times it is as if the state were prepared at a different temperature, or, especially in low-dimensional systems, in some exotic state of matter. Recently, some progress has been made in extending this picture to inhomogeneous systems. In particular, an exceptional phenomenon was pointed out: a localized perturbation can have global effects on the stationary properties of the observables. LoCoMacro is born of this observation and has the ultimate aim of finding novel ways to control the macroscopic properties of a nonequilibrium state by acting on a small part of the system. We address the fundamental questions of relaxation and emergence of nonequilibrium steady states in the presence of inhomogeneities; we study the effects of localized perturbations on the key elements of the dynamics, as the conservation laws. In integrable models we use the most advanced analytic techniques to obtain exact results, e.g., for correlation functions and entanglement measures. More generally, we rely on state-of-the-art numerical simulations. For the defining characteristics of the models studied,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanoplatforms for Neuroscience' to be submitted under Horizon Europe.

assistant: **Abstract**

NeuroNanotech will train eleven researchers to tackle one of the major challenges in Europe’s ageing population - neurological diseases.The ability to monitor and modulate neural activity using interfaces has enabled a better understanding of brain function and has led to therapeutic solutions for some neurological disorders. Yet, fundamental technological challenges, such as ensuring proper brain tissue interfacing and reliable long-term recording/stimulation after implantation, impede widespread clinical use. New approaches to provide effective treatments are urgently needed. NeuroNanotech will develop novel nanostructured flexible neural interfaces with highly improved tissue integration, minimizing foreign-body reactions and tissue scarring and allowing stable stimulation treatments. As main innovation, we will develop minimally invasive, ultra-sensitive spintronic magnetic sensors able to record stably without interfering with stimulation signals and avoiding electrode degradation. Connecting both interfaces, we will construct a low-invasive, closed-loop neurostimulation system that integrates feedback signals from the neural activity and provides real-time stimulation of the target structures according to the patient´s needs. To achieve these goals, NeuroNanotech brings together experts in nanotechnology, device engineering, neuroscience and clinical neurology. The individual research projects are highly interconnected, ensuring interdisciplinary training. Researchers will benefit from training in advanced research and relevant complementary skills, imparted by an international and intersectoral consortium of research institutes, universities, companies, hospitals and social organisations from 9 different countries. We will provide researchers a unique environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'LArge Passenger Aircraft Reliable Touch Screen.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The purpose of LAPARTS is to develop a Touch Screen Control Panel (TSCP) system that can host all functionalities currently hosted on the Overhead Control Panel (OCP). The OCP today consists of numerous electro-mechanical switches, buttons, knobs and annunciators connected with discrete wires to the aircraft systems. The current state of art of OCPs has several issues with ergonomic, economic and environmental implications. The TSCP system will address these issues while hosting highly safety critical functions. The TSCP system will be compatible with up to catastrophic failure conditions and will secure the control chain from the touch sensor to the controlled system and back to the display. In a first phase (ending Aug. 2019), TSCP prototypes will be integrated and evaluated in an enhanced cockpit simulator and potentially flight test platforms, targeting an evolution of the cockpit for existing aircraft. In a second and conditional phase (ending end of 2023), the TSCP will be integrated and evaluated in a disruptive cockpit simulator, targeting a revolution of the cockpit for deployment in future aircraft at the longer term. The TSCP will be developed following a user centred design methodology paying a lot of attention to human factors and end user interests. LAPARTS will adopt a sophisticated combination of projected capacitive and force sensing technologies in the touch screen in order to achieve the required safety levels while preserving user comfort. LAPARTS will contribute to WP3.1 of the LPA IADP (tactile HMI), including weight reduction, manufacturing and usage cost reductions and recommendations towards the certification authorities. LAPARTS will also advance touch screen technology for use in turbulence conditions and safety critical applications.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Three-dimensional molecular structures of proteins deduced from genome sequence data by homology modelling'.

assistant: **Innovation**

The human genome encodes about 100000 different proteins. As a result of genome sequencing projects the sequences of nearly all of these will be known (from cDNAs) by about 1997 or 1998. For only about 500 human proteins are 3D coordinates known, and this number only grows slowly. The imbalance between these two types of knowledge can be reduced considerably by making use of the technique of homology modelling. At the moment, about one in six new eukaryotic sequences can be modelled , and we can therefore confidently estimate that about 20000 models can be built by 1998. The goals of the project are: - development of tools to produce reliable structural models of proteins from genetic sequence data using the technique of homology modelling; - improvement of both statistical and physical modelling methods to assure the highest possible quality of the models; - modelling about 20000 human proteins from genome-derived sequences; - the public availability of these models and the model building tools to European researchers and educators as a service over Internet; - provision of viewing and analysis software for personal computers and workstations to assure the widest possible dissemination of knowledge about three-dimensional structures of human proteins. The modelling servers will be freely available not only to academic but also to industrial users. One of the servers will guarantee complete confidentiality for those that require it. Synergistic effects are anticipated with other European projects, such as the planned European branch of the PDB, the SRS project of linking databases, and projects aimed at linking human genome databases, such as IGD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From conopeptide scaffolds to analgesic leads' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This proposal is focused on the use of conopeptide scaffolds for discovery and engineering of novel analgesics. A combination of polemic and selection methodologies will be used to identify conopeptide legends for receptors of clinical importance in chronic and naturopathic pain syndromes, namely the SNS tetrodotoxin-resistant sodium channel, and the p75 neurotrophin receptor. The multidisciplinary research program combines efforts of seven academic and two industrial groups, working in fields that include protein chemistry, protein folding and engineering, functional genomic, interaction selection systems, molecular physiology of pain pathways, and CNS delivery mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European college of biogerontology' (LINKAGE).

assistant: **Concept**

Coordination and consolidation of European Biogerontology will represent a step forward en route towards the formation of a European College of Biogerontology. LINK-AGE will be a Coordination Action building upon, and very significantly extending, existi ng European research in this field. Such research is at present highly fragmented, limiting the ability to progress in an area of great economic and social importance for the future of Europe. LINK-AGE will provide an open, transparent mechanism to integr ate research by adressing the following core objectives : 1)To identify and help implement common research strategies that will generate critical mass ans added-value from European biogerontology research. 2) To establish a process that will help bring new researchers into the field from new geographical regions within the wider European community. 3) To establish a process that will bring new researchers into the field from other research area within life sciences and health of relevance to ageing and longevity. 4) To establish a framework that will allow effective integration of research on different species to maximise the opportunities for synergy and interaction between researchers working on such species. To meet these objectives, LINK-AGE will establish it membership in an inclusive way, using clearly defined criteria for scientific quality and relevance to its objectives. It will support a closely coordinated programme of topic working groups, workshops and conferences, summer schools and dis semination activities. Through its dissemination activities, it will develop effective links with the wider public, industry, policy makers and stakeholder groups, in order that translation into benefit of emerging knowledge of the underpinning science of healthy ageing ca