RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sex and the maintenance of diversity in heterogeneous habitats'.

assistant: **Objectives**

An understanding of the mechanisms that generate and maintain biodiversity is fundamental in current biological research, both from a fundamental and an applied viewpoint. In this project, we address how the interplay between environmental heterogeneity and breeding system variation affect diversity at multiple levels of biological organization. Using the model organism Caenorabditis elegans and the powerful tool of experimental evolution, we propose to test hypotheses concerning the maintenance of polymorphisms in environments where resources are spatially heterogenous.Specifically, we will investigate:(1) whether adaptation to different resources entails fitness trade-offs;(2) how density regulation at different levels affect the maintenance of genetic diversity and(3) whether the occurrence of an out-crossing mode of reproduction hampers the maintenance of polymorphisms due to recombination among locally-adapted populations.Moreover, we aim at tackling the genetics underlying the process, using the molecular biology technology available for studying this organism. We will follow the evolution of replicate populations during fifty generations for characters related to fitness and also gene diversity at the molecular level. Predominantly selfing and exclusively out-crossing populations of C. elegans are already established at the host institution. This project comes as a follow-up of the research carried out by the candidate during her post-doctoral studies, and matches perfectly with the research of the host institution as well as with its long-term aims. We expect that the results from this project will contribute decisively to evolutionary theory epical verification. The fellow will take this opportunity to return to her country of origin and set paths for an indepe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional genomics for biogenesis of the plant cell wall' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Plant cells are surrounded by a strong wall composed mainly of polysaccharides. This wall is essential for the form of the plant and allows the plant to stand upright, and the wall is the first line of defence against invading pathogens. Very little is known about how the wall polysaccharides are formed and integrated into the wall. Many enzymes are necessary for biosynthesis of the polysaccharides; the majority are glycosyltransferases (GTs) but also transglycosidases are involved.The overall objective of the project is to assign function to genes involved in the biogenesis of plant cell wall polysaccharides. A functional genomics strategy will be pursued using Arabidopsis thaliana as the model:1) Development and use of bioinformatics to predict which open reading frames are involved in cell wall biosynthesis.2) Reverse genetics. A high throughput approach will allow investigation of at least 100 GTs. Clones will be produced in GateWay entry vectors for the easy sub-cloning in vectors for expression, epitope tagging etc. The activities of heterologously expressed enzymes will be determined using assays developed in the project.3) Novel analytical tools for characterization of polysaccharides in the mutants will be developed and applied including antibodies and carbohydrate binding modules for in situ polysaccharide analysis, mass spectrometry, polysaccharide sequencing, substrate-chips for surface plasmon resonance, glyco-chips for activity screening etc.4) Protein-protein interactions between the identified enzymes and other proteins will be investigated by proteomics, epitope tagging and bioimaging.The network consists of 10 partners from 7 countries and will provide an outstanding environment for training of young researchers. In addition to the training implied in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stochastic Geometry and Novel MAC Schemes for Enhanced Satellite IoT Networks' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The SATNET-IoT project addresses the significant challenges of extending IoT connectivity through satellite networks, particularly in remote areas where terrestrial coverage is insufficient. With terrestrial networks covering only 25% of the global landmass, satellite-based IoT solutions have become crucial for achieving any-time, any-device connectivity. The rise of non-geostationary orbit (NGSO) satellites, with their lower latency and improved data transfer speeds, offers promising opportunities for IoT communication. However, performing orbital simulations to know the exact locations of the satellites for each of them is time-consuming and computationally complex. Also, any new solution analysed based on specific satellite orbits cannot be generalized for other constellations. SATNET-IoT aims to utilize stochastic geometry for developing a mathematical framework to analyze the potential improvements in coverage across different regions and times offered by satellite networks, without requiring precise orbital data. The existing IoT communication protocols are also not designed to manage the dynamic, intermittent coverage inherent to satellite networks, nor do they account for the higher propagation delays and rapidly changing topology. SATNET-IoT aims to overcome these challenges by developing novel medium access control (MAC) layer protocols, ensuring efficient transmission scheduling and resource allocation within limited satellite visibility windows. The developed stochastic geometry framework and algorithms will be validated by deploying a real-time IoT network for air quality monitoring using software-defined radio to emulate satellite constellations.


**Keywords:** Satellite Communications, Stochastic Geometry, Software-defined-radios, Medium-access-control,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Population transcriptional genomics in humans using high throughput sequencing'.

assistant: **Objectives**

Gene expression is one of the marks of cellular state and function. The relative abundance of transcripts defines and is a result of the differentiation status of a cell. Interrogation of gene expression levels and patterns in the human and other genomes can be informative about perturbations from the  average  pattern due to external stimuli or internal factors such as genetic variants. Gene expression profiles have been extensively used to assess developmental processes, pathways contributing to cell differentiation, and predicting the outcome of disease status.Understanding the effects of genetic variation in basic cellular processes such as gene expression is key to the dissection of the genetic contributions to whole organism phenotypes.We propose to interrogate the transcriptome of primary fibroblasts, primary T-cells and EBV-transformed B-cell (lymphoblastoid cell lines or LCLs) from umbilical cords of 200 individuals of European descent using next generation sequencing (mRNAseq). A subset will also be interrogated for transcriptionally engaged RNA polymerases (GROseq) and protein abundance. These data will be analyzed for the detection of eQTLs and other genetic effects associated with variation in alternative splicing and other properties of the transcripts and dissection of the genetic effects from primary transcription to protein and their tissue specific effects. These data will be integrated with genome-wide association studies and other efforts to dissect the genetic basis of complex traits and diseases in humans. In addition, we will develop bioinformatic models to understand the fine scale regulatory signals that are responsible for the regulatory patterns observed and how sequence variants have an effect on them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Agonists of the microprotein BRAWNIN in the treatment of Charcot Marie Tooth disease'.

assistant: **Concept**

This project will provide proof of concept for the neuroprotective potential of agonists of the mitochondrial protein BRAWNIN. We have identified that BRAWNIN is an important regulator of mitochondrial function in neurons. Mitochondria are essential organelles to support metabolic homeostasis in the cell. Mounting evidence in the literature demonstrate that mitochondria and more broadly metabolic regulation is central to the function of the nervous system. Axons are especially affected by metabolic deregulation, which can lead to axonal degeneration. In this application, we propose that increasing the cellular levels of protein BRAWNIN using a gene-therapy strategy (defined as BRAWNIN agonists) will be protective in neurodegenerative disease, and we will demonstrate this in models of Charcot Marie Tooth disease, a peripheral neuropathy strongly associated with altered metabolism and mitochondria. Overall, our project will provide the first demonstration that BRAWNIN is a target of therapeutic interest in axonal metabolic diseases, which we will further develop with the ultimate goal to develop BRAWNIN agonists for patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Commercialisation of Ventura Habitat - a novel wind turbine blade maintenance enclosure to maximize downtime productivity' (2014-2020).

assistant: **Innovation**

GEV Wind Power is one of Europe's leading wind-turbine maintenance companies with teams working on more than 40 wind farms both on and offshore every year. With a presence throughout Europe and North America, GEV Wind Power is a truly global service provider. We understand that it is important to wind energy maintenance companies to find new ways of delivering core services to reduce the cost of energy provision. To realise this vision, we commit significant financial resources to in-house R&D and are constantly looking at technologies that fit well for Wind Energy. We have now developed a patented habitat solution that retrofits to market available access platforms. This creates the perfect protective working environment for blade maintenance and repairs to be completed. Maintenance productivity is increased and, with the added benefit of 24 hour working, GEV Wind Power are able to eliminate the cost uncertainty of weather downtime and will help wind farm owners reduce maintenance costs, improve Annual Energy Production (AEP) and the competitiveness of wind generated energy. Trials completed onshore with our Ventura Habitat prototype using two different access platforms (Power Climber and Kaeufer) in varying weather conditions and ranging between 30 metres and 100 metres high, with successful deployment demonstrating the flexibility and operability of the Habitat in a real-life environment. The overall objective of this development project is to create a commercially ready Ventura Habitat system, with validated results through field trials. This will enable us to achieve our overall commercial objective to become the leading blade maintenance services provider in Europe and North America. We forecast a total revenue of €20 million and a profit of €5 million 5 years pos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'European Network of Research Councils in the Humanities'.

assistant: **Concept**

In the development of the European Research Area, the contribution of the humanities is essential. Research in the Humanities is instrumental not only in understanding but also in the transformation of society. The humanities in Europe are recognised for their profound impact on the language, culture and history of different European peoples. Much of this research has had a strong national focus and there has been relatively little collaboration across national boundaries. By applying a comparative approach to research in the humanities, it will be possible to transcend such historic national limitations and to develop new collaborative research agendas. Research in the humanities is crucial in defining European identity and bringing about intercultural dialogue. The humanities can both investigate issues deemed to be of wider significance to the European Union and also raise questions that result in entirely new scientific insights. The main objective is to strengthen European research in the humanities. In light of the ongoing debate about the structuring of the European Research Area, there is an urgent need to underpin mutual interaction within the humanities and to facilitate the contribution of the humanities in the debate in the EU, in the dialogue with politicians, with the executive of the EU Commission and with national research administrations. The European Network of Research Councils in the Humanities (ERCH) has been established with this objective in mind. The SSA is the roadmap for a proposal for an ERA-NET CA. The SSA will develop the ambitions of the ERCH to find national fields of research suited for joint programmes to be developped in the CA proposal. The SSA will enable the directors and the programme managers of the three partners to identify possi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Market Design and the Evolution of Markets' (MADEM).

assistant: **Concept**

The broad aim of this research program is to understand how markets get created, how they evolve, and how specific market organizations affect economic outcomes. It combines theoretical and empirical analyses of specific markets and includes the development of new methods to map theory to data and vice versa. Each market provides a concrete ground to explore the broad questions the project addresses and motivates a distinct set of questions. The first class of markets the research will consider are financial markets. These can be viewed as the archetype of large markets where prices play the main role in the allocation. The focus there will on market creation, market evolution and the process of competition. The second class of markets the research will consider are allocation mechanisms where prices do not play a role in the allocation, making efficiency hard to obtain. The focus there will be on strategic manipulation of preferences by participants, their consequences on outcomes and possible remedies. Together, these markets will contribute to our understanding of how market rules affect outcomes and performance, to what extent laissez-faire evolution fosters efficient market organizations, and when and how public intervention can help generate better market organizations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'NMR insights on the soluble Guanylyl Cyclase conformational dynamics to illuminate the SIGNaling pathway'.

assistant: **Objectives**

Gas-sensing proteins play an important role in mediating biological events. Soluble guanylate cyclase (sGC) is activated when nitric oxide (NO) binds to heme Fe of sGC, and then stimulates cyclization of guanosine 5-triphosphate (GTP) to the second messenger cyclic guanosine 3,5-monophosphate (cGMP), which in turn has a direct role in the control of a variety of physiological processes in several signal transduction pathways. Disruptions in the NO/sGC/cGMP signalling pathway have been linked to a variety of diseases including congestive heart failure, stroke, hypertension and neurodegeneration. In this proposal, we will derive novel molecular insight into the heme-containing sensor domain of human sGC that is the primary receptor for NO and therefore plays a significant role in NO-signalling by employing structural and computational methods. The project will use the power of solution NMR spectroscopy and enhanced conformational sampling computational approaches to improve our atomistic understanding for this key biological protein and to identify a representative conformational ensemble that will be used in virtual screening of chemical libraries, so as to identify new, original, and more effective compounds for the activation of sGC. This novel approach of combining NMR and computational MD data to identify receptor conformations that play a major role in biomolecular recognition before commencing the structure-based virtual screening is expected to have a major impact in the field of drug design. Throughout this fellowship, the fellow will gain invaluable experience by combining the already accumulated experience in computational biology and CADD with advanced methods using NMR and computational data for the study of biomolecular structure and dynamics. This fellowshi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Surface-enhanced Raman spectroscopy in liquid biopsy for breast cancer' in the context of a Horizon Europe call.

assistant: **Objectives**

Despite current large-scale mammography screening programmes, breast cancer is still the leading cause of cancer death in women in the vast majority of countries. It is recognizable that cancer deaths could be prevented through earlier diagnosis and adequate treatment. Therefore, new vigilant diagnostic tools that could provide an earlier diagnostic should be developed. The progress regarding sensitive, robust, fast, and cost-effective biosensors is a very active research field. Surface-enhanced Raman scattering (SERS) spectroscopy is a powerful technique for ultrasensitive label-free analysis of chemical and biological samples with wide applicability, vastly demonstrated for cancer.  Nevertheless, translation of SERS to the clinics and industry is limited due to the lack of reproducible substrates and automation routines to analyze complex spectra.    Liquid biopsy is the most commonly used practice for clinical preliminary disease screening. Some groups have already shown noteworthy work addressing the potential of SERS in blood plasma and urine, making it suitable for rapid and minimally invasive cancer diagnosis. SERS can be applied to sense subtle changes in composition and structure of biomolecules in plasma/urine from cancer subjects. Allied to this, discriminant analysis models (DAM)  have been applied to SERS. These studies demonstrate that a powerful diagnostic system can be built for cancer screening with very high specificity and sensitivity.The main objective of SIREN is the development of a liquid biopsy test on which highly sensitive solid SERS substrates will detect changes in biomolecular profile between cancer and no cancer samples. Blood plasma and serum, and urine will be used in a label-free detection. Combining with new developed clinical decision-