RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Commercial introduction of the first Airborne Wind Energy system: Renewable energy at costs below fully depreciated coal fired power plants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Ampyx Power develops the PowerPlane, an Airborne Wind Energy System (AWES). AWES are second generation wind turbines that use the stronger and more constant wind at altitudes between 100 and 600 meters.Project AMPYXAP3 concerns the design, construction and testing of the first article of an initial commercial PowerPlane, version AP3.The global transition to a sustainable energy supply is burdened by the exorbitant societal costs associated with it. Renewable energy infrastructure projects have extremely high capital costs, and in most cases the cost per kWh of renewable electricity produced exceeds the cost of fossil-fuelled alternatives, thus requiring subsidies or other supportive instruments from governments. The economic effects of the energy transition are very significant, including the deterioration of international competitive position of countries or regions with high ambition levels regarding climate change, such as the EU – caused by rising electricity prices for industry. PowerPlane technology will have a disruptive effect on the electricity generation sector; due to the low levelised cost of energy (LCoE) that can be achieved with it, and due to its low capital costs.The need for a low cost, low capital investment renewable energy technology is evident. The AP3 PowerPlane, to be developed in the AMPYXAP3 project, fulfils the customer need of PowerPlane technology demonstration in long-term continuous safe operation at costs and LCoE as predicted.Ampyx Power aspires to manufacture and sell PowerPlane systems, as well as deliver operational and maintenance services to wind park owners. As a consequence, Ampyx Power projects revenues from PowerPlane system sales and installations, as well as from operation and maintenance (O&M) contracts. Hence, the AMPYXAP3 p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'UTILIZATION OF PRIVATE LAND FOR MAINSTREAMING NATURE-BASED SOLUTION IN THE SYSTEMIC TRANSFORMATION TOWARDS A CLIMATE-RESILIENT EUROPE'.

assistant: **Concept**

LAND4CLIMATE aims to increase the resilience of landscapes and urban settlements in the continental biogeographical area and beyond by nudging the implementation of nature-based solutions (NBS), which are at large-scale still in its infancy. However, there are three reasons for the tardy uptake of NBS in practice: (1) NBS need more land than grey infrastructure; (2) approaches to NBS hitherto often focus on public land; (3) private land, however, bears huge potential for climate resilience, both as a supplier (in terms of ecosystem service provision) and a recipient of benefits of NBS (in terms of climate risk reduction). LAND4CLIMATE addresses these implementation gaps.Climate resilience needs land! LAND4CLIMATE aims to get access to private land for the implementation of NBS, not by buying land, but through the development of innovative governance schemes and business models, such as land readjustments schemes, strategic land leases and easements. The main objective of LAND4CLIMATE is to co-design and validate NBS on private land through implementation and upscaling with innovative strategies of land policy for a transformative climate-resilient future in areas with multiple risks, especially coupled extreme hydro-meteorological events such as floods, droughts and urban heat.LAND4CLIMATE will operationalize this objective in six frontrunner cases in Austria, Czechia, Germany, Italy, Romania and Slovakia by: •Identifying cause and effect relations of climate risks and NBS to allocate NBS effectively and efficiently•Developing governance and business models to implement legitimate and just strategies of land policy for NBS on private land •Enabling successful replication and upscaling By involving seven replicant regions in the aforementioned countries, LAND4CLIMATE bec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Harnessing of hematopoietic stem cells for targeting of brain metastases'.

assistant: **Concept**

Brain metastases occur in 20 to 35% of cancer patients and are associated with poor prognosis due to the lack of efficient treatments. Targeting of brain lesions poses several challenges including the poor penetration of drugs into the brain due to the tightness of the blood-brain barrier. Therefore improved approaches for the delivery of therapeutic agents to brain lesions are urgently required.The goal of this project is to develop a cell-based strategy to deliver therapeutic agents to brain metastases. This will be achieved by stable introduction of genes encoding secreted therapeutic molecules with anti-cancer properties into hematopoietic stem cells (HSCs). Upon transplantation, the progeny of HSCs will home to cancer lesions, thereby delivering the therapeutic agent of choice.We already demonstrated that the progeny of genetically engineered HSCs readily crosses the blood-brain barrier and homes to brain metastases in animal models where it efficiently expresses the delivered gene. Here we aim to further improve our approach in pre-clinical models to facilitate its clinical translation. To this end we aim to improve the efficiency of therapeutic delivery by increasing the infiltration of HSC progeny into the brain via whole brain radiation, a standard therapy for brain metastases. Secondly, we aim to improve the specificity of therapeutic delivery by identification of gene promoters that are active specifically within HSC progeny infiltrating the tumour. Expression of therapeutic agents by these promoters will restrict their delivery to tumour lesions. Thirdly, we aim to demonstrate a therapeutic efficacy of HSC-based drug delivery in combination with an enzyme / prodrug approach.Due to the advanced application of HSC transplantation and HSC-based cell therapies i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flow-stimulated ion channel signalling in renal epithelia' (2014-2020).

assistant: **Innovation**

The principal role of the kidneys is the critical regulation of our electrolyte balance, through an integrated system of reabsorption and secretion of fluid and electrolytes. Once blood is filtered in the glomeruli, renal electrolyte reabsorption rate has to be adjusted to the variable electrolyte load associated with fluctuations of the pro-urine flow. The variable flow of pro-urine results in changing fluid-shear stress (FSS) that activates mechanosensitive signalling pathways in the epithelial cells of the renal tubule. Hence, the kidney’s sensing ability adapts epithelial function to the dynamic tubular environment. Preliminary data from the host laboratory shows that polycystin-1 (PC1), a mechanosensitive entity in renal epithelia, is involved in the FSS-mediated signalling response by increasing the ATP release. Moreover, mice with a kidney-specific knockout of the PC1 encoding gene, Pkd1, exhibit significant electrolyte imbalances. The focus of the present project proposal is to elucidate how FSS modulates renal electrolyte handling by exploiting PC1-deficient renal cells and animal models. This will provide new insights into the flow-sensing mechanisms in the kidney. Specifically, the role of ATP-mediated signalling pathways in the regulation of ion channels and transporters in the distal part of the nephron will be investigated. To this end, the following work packages will be addressed: A)Control of electrolyte reabsorption by FSS. Assess the expression and function of FSS-regulated transporter proteins in Pkd1-/- cells.B)Translation of FSS into ATP signalling to regulate renal electrolyte handling.It is my aim to identify the downstream proteins involved in FSS-mediated ATP signalling and decipher their role in electrolyte handling in vivo. Taken together, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated microsystem for the magnetic isolation and analysis of single circulating tumour cells for oncology diagnostics and therapy follow-up' (MASCOT), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of MASCOT is to exploit breakthroughs at the confluences of micro-, nano- and bio-technologies to create a low-cost minimally-invasive intelligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of rare cells from complex mixtures and using an array of nano-biosensors, integrated with micro-scale amplification, for the consecutive RNA/DNA analysis of the isolated rare cells.Advances in molecular biology and biosensor technology and the integration of nanostructured functional components in macro- and microsystems will facilitate the isolation of rare cells on the basis of novel markers, cell size, tailored surface chemistry and labeling with magnetic particles. The advantages of the exploited biosensors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effectiveness. Addressing the health care requirement of the future of an individualised theranostic approach, the specific applications that will be demonstrated in MASCOT will be the isolation and RNA/DNA characterisation of both lung and breast cancer cells (more specifically, circulating tumour cells or CTC's), from respectively sputum and peripheral blood or bone marrow.The radical innovation proposed in MASCOT will result in a concrete prime deliverable of a technology platform of wide application and unquestionable socio-economic benefit, increasing European competitiveness whilst contributing considerably to the quality of life of the population and control of health care cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CirculArity Enhancements by Low quality Scrap Analysis and Refinement' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Today, the European Union?s steel sector is a modern industry with its main customer base found within the EU home markets, particularly in high-end segments. However, challenges remain to keep the EU steel sector both competitive at a global level and climate-neutral, in line with the European Green Deal and the CleanSteel Partnership?s vision.The scrap usage in steelmaking is a common practice to improve the process? sustainability, as it decreases the use of virgin raw materials and boosts the circularity of the sector (decreasing  CO2 emissions and electivity consumption). Nevertheless, the current trend in the EU scrap market points at a slight decrease in the pre-consumer scrap and an increase in the short- and long-term of the post-consumer scrap stream, due to an increase in steel consumption. Nowadays, these ?low-quality? scrap streams are not suitable for most applications, thus limiting their use in steelmaking.In order to increase the steel scrap recycling capacity and energy efficiency, while keeping EU competitive and safe in terms of raw materials imports, energy consumption and climate change impact, innovative technologies to ?clean? the scrap before it reaches the steel furnaces need to be implemented. CAESAR gathers up steelmakers, technology developers and research centers in a joint effort to validate, at full-size industrial scale, integrated scrap upgrading, sorting and characterization technologies, thus enabling to untap volumes of low-quality scrap streams in Europe, while keeping a high-quality product and generating valorization routes for all the non-ferrous fractions obtained, towards a zero waste steel sector.


**Keywords:** steel scrap utilisation, circular economy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Dissecting the retinal inputs to behaviorally relevant computations in the central brain'.

assistant: **Objectives**

A key function of the visual system is to extract behaviourally relevant features about the visual scene from the barrage ofincoming photons. This process begins in the retina, a powerful image processer that recent studies have revealedseparates the incoming information into ~20 distinct neural representations. Within central visual brain regions specificdetails of the visual scene are often neatly organized, remaining spatially segregated from each other. Despite our detailedknowledge of how information is organized within the visual system, progress in gaining a mechanistic understanding ofhow the brain is able to extract salient features from the visual scene, or how this information is used to guide behavior hasstalled. Too often each brain centre is studied in isolation, meaning the details of its inputs and function of its outputs arefrequently a point of conjecture. In particular, the input to central visual areas, despite the accumulated evidence, arerepeatedly assumed to simply be a relayed representation of the visual scene from the retina.In order to provide mechanistic insight into how visual information is processed in central brain regions and understand howit is used to direct behavior this proposal will delineate the inputs, originating in the retina, to specific behaviouralcomputations in central brain regions. This will allow us to determine which retinal channels are assigned dedicatedcomputational tasks and how information from the retina is recombined to highlight key aspects of the visual scene used todirect behavior. To accomplish this conditional expression systems and trans-synaptic viral based circuit tracing will becombined with targeted patch-clamp recording and calcium imaging to link genetically identified cell types of the retina withbeha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'THRIVING IN THE WORKPLACE - SUPPORTING PEOPLE AT THE AGE OF 55 YEARS AND OVER IN SATISFYING AND PRODUCTIVE WORK' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Workers aged 55+ are not always utilised or valued as much as they could be in the workplace, yet their contributions are increasingly necessary as the European population ages. Many of them need to work for longer than they expect, due to pension fund shortfalls and changes in official retirement ages. For some, this will require a change in perspective and strategies for managing self and career. The proposed project will integrate currently fragmented approaches to show how older workers experience their ageing in the workplace (including others’ perceptions of them), their strategies for dealing with it, and the consequences for their productivity and well-being.  Interviews will be conducted with 40 workers aged 55+ and 8 human resource managers in four organisations in the IT sector and four in the health sector - two organisations of each type in the UK and in Bulgaria. A conceptual model will be developed and tested using mainly quantitative questionnaire data from 500 workers aged 55+ in the same two countries and sectors. This will identify how the workplace (including human resource practices) can be designed to facilitate the successful participation of older workers, and also the best strategies workers themselves can use.  Case studies, guidance notes and training materials will be produced and piloted. The conduct and dissemination of the work will be achieved with the co-operation of a number of organisations that promote effective practices at work. Many are already well-known to the researcher and the host organisation.  Academic papers will be published in leading journals based in Europe. Dr Stanimira Taneva is the proposed researcher. She has substantial experience in applied psychology research and in promoting the career development of diverse gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Excellence in Galaxies - Twinning the IAC' in the context of a Horizon Europe call.

assistant: **Objectives**

With this Twinning With this Twinning action we aim to strengthen the research and networking capacity, profile and impact of the Instituto de Astrofísica de Canarias (IAC) in the area of galaxies through the development of strategic alliances of this regionally leading institute in an Outermost Region of the EU (OR), with three excellent European partners. An initial SWOT (strengths, weaknesses, opportunities and threats) analysis of the galaxies group has revealed that it is strong and internationally relevant in the area of optical observational research in galaxies, but that, in order to remain competitive and increase its national and international impact, it needs to strengthen in the areas of numerical modelling, radio astronomy, the exploitation of the most modern observational surveys, as well as European proposal preparation and management. We therefore team up with three very important European partners, the University of Groningen (RUG) in particular for radio astronomy, the University of Durham (ICC) for numerical modelling, and the CNRS - Observatoire Astronomique de Strasbourg (ObAS) for exploitation of modern observational surveys. Each of these partners has a long history of world-leading excellence, performed by teams built around prize-winning scientists. We aim to perform joint research, develop strategies for increased competitiveness, and ensure sustainable improvements as well as lasting collaborations in world-class science. In parallel, we will enhance the capacities within the IAC in top-level project management, administration and strategic skills, and share the new-found excellence and best practice with academic and industry partners in the region. Our project contains a research pilot aimed at using the most modern opportunities achievable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Diagnosis of preterm birth risk and success of induced labour' under Horizon 2020.

assistant: **Concept**

ContextPreterm Birth (PTB) is the birth of a baby before 37 weeks of pregnancy. ProblemPreterm Delivery- Leading cause of death in children under 5 years- Affects more than 15 million births a year- Preterm rates are increasing, particularly for extremely preterm birth (less than 28 weeks)- Many survivors face a lifetime of disability, including learning disabilities and visual and hearing problems.- Immediate costs of a PTB are on average 10 (31-34 weeks) to 100 (25-27 weeks) times more than a full-term one.The total cost of PTB in the US was estimated at $26 billion.There are currently no tools that accurately diagnose and predict PreTerm BirthSolution – Fine BirthFine Birth is an in-vivo diagnostic technology that uses torsional ultrasound to study the shear mechanical properties of thecervix tissue. We can accurately identify if and when a baby will be born prematurely and also quickly and cost effectively identify if a PTB is imminent. By improving the sensitivity of current techniques from 30% to 70%, we can decrease the number of Preterm Birth cases and reduce their impact on patients and health systems.Fine Birth could avoid 369,000 Premature Births and save more than 22,000M € only in USA & Europe by accurately predicting PTB, while saving 800M€ in identifying imminent PTBs.ProjectWe aim to use the feasibility study to test our business model. Furthermore, we aim to hold conversations with different players along the value chain and generate interest.During the phase 2 we aim to clinically validate and certify a POC device and prepare it for sublicensing.Impact & MarketBy 2024, we aim for Fine Birth to be integrated in 7.5% of the diagnostics ultrasound devices for Obstetrics/ Gynaecology market with sales of 3,115 units, generating sales of 9.3€M and an IRR of