RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Methodologically Accurate Modelling of BOne: new experimental methods for the validation of cortical bone tissue computer models'.

assistant: **Innovation**

Multiscale modelling of the human body is becoming an essential approach in large part of biomedical engineering research, as well as in the development of technologies for clinical applications, such as the Virtual Physiological Human. Bone is a hierarchical material and plays a fundamental role in the framework of the musculoskeletal system. In the last years the bone models at the tissue level (10-10000 microns) have been considered the weakest link in the multiscale modelling chain due the complexities of defining reliable experiments to validate them (i.e. to verify their accuracy in predicting the reality). The goal of the proposed study is to generate a set of accurate experiments for the validation of numerical models for cortical bone by using state of the art experimental techniques (micro-CT, nano-indentation), image processing (Digital Image Correlation) and engineering numerical methods (Finite Element (FE) models). To do so, a custom made jig will be designed to be able to perform stepwise loading on cortical bone samples inside a micro-CT. The sample’s mechanical properties and the strain field will be computed between each loading level and compared to the outputs of the FE models generated from the acquired 3D images. The output of this project would be relevant for a variety of clinical and basic research applications: osteoporosis, osteoarthritis, regenerative skeletal medicine, fractures associate to bone tumours, better understanding of association between form and function in the skeleton, etc. Moreover, the bone research community would benefit from the sharing in Public Domain of reliable experimental results that could be used by other researchers as a benchmark for their modelling methods. The expertise of the researcher (Enrico Dall’Ara), the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cognitive Common Currency or Contextual Bargaining ? A new model for food preferences' to be submitted under Seventh Framework.

assistant: **Abstract**

Research has for long focused on what people choose, not how they choose. In the  domain of food choices, like elsewhere, the dominant model is that preferences are comparative judgments between quantities of sensory pleasure. Significant development lately in the cognitive neurosciences on the many roles of hedonic systems in choices and behavior have put pressures on this classical ‘common currency’ (Cabanac,1992) model of decisions. They stress the variety of low-level, automatic, sub-personal influences bearing on food choices,  and show that behaviour can be ‘nudged’ in context (Thaler & Susstein, 2008). This still doesn’t address the nature and the role played by food preferences at the conscious, personal level.The objective is to provide such a model. The timely interdisciplinary methodology draws on  cognitive sciences and philosophical models of the mind, advancing bridging the gap between the study of evaluative and perceptual processes. Guided by recent models in multi-modal flavour perception (Auvray &Spence, 2007), 4CB defends a model of contextual bargaining for food choices. It combines conceptual and experimental approaches, and is set up in the interdisciplinary Center for the Study of the Senses. It defends and puts to test two key proposals by distinguishing different kinds of preferences (contextual/automatic/reflective) and contextual influences on them (multisensory context and cognitive context of consumption). Consequences for the wider concept of ‘preferences’ and impact on heath and food policies are integral to the project.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Investigating how somatic mutation induced changes in the eutopic endometrial microenvironment cause endometriosis'.

assistant: **Objectives**

Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus and chronic inflammation. Worldwide, >10% of reproductive-age women suffer from pain and/or infertility caused by this disease. Recently, cancer driver mutations have been identified in both the eutopic and ectopic endometrium of endometriosis patients. Moreover, it has been shown in cancer studies that cancer driver mutations can alter the local immune microenvironment. Nevertheless, it has never been studied how cancer driver mutations present in the eutopic endometrium of endometriosis patients contribute to the pathogenesis of this disease. Therefore, I propose to investigate how these mutations that are present in the eutopic endometrium alter the local eutopic immune microenvironment and thereby drive endometriosis  development. This theory is what the acronym MERMAID in this proposal stands for: Mutations in Endometrial Regions and Microenvironmental Adaptations Influence Disease.To this end, I will analyze cell viability and immune cell signature in the menstrual fluid of people with and without endometriosis and identify which cancer driver mutations are present in their endometrial epithelial cells. In addition, I will create a mouse model to study the role of these mutations on the local immune microenvironment and in early endometriosis development. The outlined proposal will not only improve our understanding about the pathogenesis of endometriosis, but it will also generate potential new diagnostic methods and lead to novel personalized treatment options. Moreover, successfully managing this project will provide me with the additional scientific and translational skills necessary for moving up the career ladder towards a position as assistant professor in academia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissection of tumor heterogeneity in vivo' (CancerHetero), addressing dissemination and exploitation.

assistant: **Impact**

It is now widely accepted that tumors are composed of heterogeneous population of cells, which contributeto many aspects of treatment resistance observed in clinic. Despite the acknowledgment of the tumor cellheterogeneity, little evidence was shown about complexity and dynamics of this heterogeneity in vivo,mainly because of lacking flexible genetic tools which allow sophisticated analysis in primary tumors. Werecently developed a very efficient mouse somatic brain tumor model which have a full penetrance of highgrade glioma development. Combination of this model with several transgenic mouse lines allow us toisolate and track different population of cells in primary tumors, most importantly, we also confirmed thatthis can be done on single cell level. Here I propose to use this set of valuable genetic tools to dissect thecellular heterogeneity in mouse gliomas. First we will perform several single cell lineage tracing experimentto demonstrate the contribution of brain tumor stem cell, tumor progenitors as well as the relativelydifferentiated cells, which will provide a complete data sets of clonal dynamics of different tumor cell types.Second we will further perform this tracing experiment with the presence of conventional chemotherapy.Third we will perform single cell RNA sequencing experiment to capture the molecular signature, whichdetermines the cellular heterogeneity, discovered by single cell tracing. This result will be further validatedby analysis of this molecular signatures in human primary tumors. We will also use our established in vivotarget validation approach to manipulate the candidate molecular regulators to establish the functionalcorrelation between molecular signature and phenotypic heterogeneity. This project will greatly improve ourunderstanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RV001: An anti-metastatic cancer vaccine' to be submitted under Horizon 2020.

assistant: **Abstract**

Prostate cancer is the most commonly diagnosed cancer in men, with 1.7M new cases and 0.5M deaths anticipated by 2030 worldwide. Although metastases are responsible in 90% of cancer deaths, in today’s standard treatment there is no active therapy after removal of primary tumor to prevent metastasis formation. 40% of patients experience relapse of cancer in the first 2 years after surgery. The existing treatments focusing on later stages, do not prevent the initial spread of metastatic cells and cause numerous undesirable side effects. Late stage immunotherapies against metastatic cancer also present major drawbacks, including high costs and adverse events. So, there is a critical unmet need for a therapy that can effectively prevent metastasis formation in early stage prostate cancer. RhoVac aims to address this need by developing the first therapeutic vaccine against early stage metastases in prostate cancer – RV001 – which could revolutionize the treatment of metastatic cancer. Through the activation of the patient’s own immune system, RhoVac projects that RV001 will induce the specific elimination of metastatic cancer cells with unprecedented levels of safety, tolerability and biological activity, proven with the successful conclusion of a Phase I/II clinical trial in 2018. RhoVac aims to develop the RV001 vaccine up to completion of a Phase IIb clinical trial (key objective of the present project), following which the company plans to out-license the vaccine to a large Pharma, with conservatively predicted revenues of ca. €1B, within 5 years of vaccine launch.Due to its mechanism, RV001 could potentially be used against all metastatic cancer types. RhoVac will seek to validate this exploratively in parallel with the prostate cancer project. In short, our aim to intr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RELIABLE TECHNOLOGIES AND MODELS FOR VERIFIED WIRELESS BODY-CENTRIC TRANSMISSION AND LOCALIZATION', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The ROVER consortium is formed by a highly skilled multidisciplinary team of experts from eight countries seeking to develop novel solutions and procedures for international adaptation of complex non-invasive on-body and in-body wireless systems for healthcare devices. The cross-sectoral and multinational composition of the consortium enables a natural route from profound basic research to health-related applications facilitating the commercialization of wireless technology innovations for international markets. The ROVER team is capable of contributing to all levels of the Research, Development and Innovation (RDI) process of new end-to-end approaches. The system architecture that the team envisions as the ultimate outcome of the four-year project is increasingly seamless, dependable, energy-efficient and secure. Our team is also capable to take into account all the features coming from 5G health vertical roadmap due to the existing research activities we have. The system architecture to be developed relies on pivotal expertise in multidisciplinary areas of engineering, physics, medicine, computer science and product development. The end to end ROVER architecture described implements non-ionizing diagnostics and monitoring augmented by secure data transfer at all levels with medical involvement does not currently exist. Individual as well as pivotal collaborative research and innovations are required to create user-required backward compatible systems beyond state-of-the-art.


**Keywords:** in-, on- and off-body communications, WBAN, UWB, human centric localization, channel  , modelling, data management, security, patient empowering, wearable sensors, remote  , monitoring, 5G
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The age-related motor handicap. Basic and clinical studies of skeletal muscle', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

- To elucidate the aetiology of the impaired muscle function in old age. - To determine how age-related impairments in muscle function are affected by medical intervention and physical activity. - To design improved regimes which will decrease the dependency and improve the quality of life of the elderly.This European transdisciplinary research project will be focused on the aetiology of age-related impairments of skeletal muscle function and the possibilities of reducing these impairments, by hormone replacement therapy and physical activity, to improve the quality of life of the aged. The project will be a combination of basic and clinical research and different experimental techniques will be used to study the effects of ageing on factors ranging from the regulation of muscle protein synthesis at the gene level to muscle function and structure in vivo, and the influence of gender, activity/inactivity and hormone replacement therapy on these effects: 1) Molecular biological techniques will be used to study the regulation of contractile protein synthesis at the gene/mRNA level. 2) In vitro motility assays will be performed to study the interaction between myosin and actin. 3) Biochemical techniques will be used to investigate the expression of contractile, regulatory and structural proteins and the sarcoplasmic reticulum in the muscle cell, motor unit and whole muscle. 4) Cell biological techniques will be applied for analysing the regulatory/modulatory influence of myosin isoforms on the contractility in single muscle cells. 5) Physiological and morphological techniques will be used to study muscle physiology and structure in vivo and their relation to the results at the cellular and molecular levels. 6) Clinical studies will be undertaken to examine the effects of ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Inequality, urbanization and Territorial Cohesion: Developing the European Social Model of economic growth and democratic capacity (COSHMO)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The principal aim of COHSMO is to investigate the relation between socio-economic structures of inequality, urbanization and territorial cohesion, and how territorial cohesion at different European scales affect economic growth, spatial justice and democratic capacities. The way that public, private and civil society stakeholders counter or cushion spatial injustice varies across localities in Europe. In common, is the need to develop the institutional capacities for place-based collaboration and democratically mobilize communities for policy development and adaption. Although location and place have gained attention in European policy and the theoretical thinking informing regional development policies, it is argued in COHSMO that we need to change our orientation in the direction of making place-informed theories and policies instead of applying existing theories and policies on places. This will be done by providing a cross-case analysis and assessment of territorial cohesion within three different cases in each of the seven national partner contexts based on a mixed-method and locality-sensitive approach. The fieldwork will focus firstly on the relation between policy instruments and local experiences of territorial cohesion, and secondly on how “social investment strategies” relate to territorial cohesion and local conditions. Moreover, the project engages in an assessment of spatial development policies at different governance scales to map the impact of different policy instruments in the fight against spatial inequality and spatial injustice. COHSMO is innovative in its differentiated approach to how location matters, and coupled with its conceptual advances COHSMO will develop groundbreaking policy recommendations in relation to sustainable economic growth, spa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Information Flow and Its Impact on Financial Markets' (INFORMATIONFLOW) under Seventh Framework.

assistant: **Objectives**

The importance of information asymmetry in financial markets has long been recognized in financial economics. Most existing models focus on the role of privately informed investors who influence prices through their trades. But in many cases the agents who have the biggest information advantage are insiders or the firms themselves; they are precluded from trading but can affect the information flow to the market. This endogenous information flow and its effect on financial market is the focus of the proposed project.By the term information flow we refer to a wide range of channels through which firms can communicate. The information can be part of a mandatory disclosure or a voluntary one. It can be verifiable or non-verifiable information. In addition there can be an implicit information transmission. A firm may choose certain actions to convey its private information (i.e. signaling) without any explicit announcements.The way firms convey this information may provide key insights into the behavior of financial markets and in particular the development of financial crises. The project combines theoretical and empirical work. In the theory part I plan to examine the channels mentioned above and develop testable implications. In the empirical part I plan to test these implications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genes And Proteins for AutoImmunity Diagnostics' in the context of a Seventh Framework call.

assistant: **Objectives**

Rheumatoid arthritis (RA) and sistemic lupus erythematosus (SLE) are two autoimmune diseases that respectively affect an estimated population of 1.537.000 and 1.272.000 of patients in Europe. Such diseases show a long prodrome during which there are no clinical symptoms. In some cases, therapeutic treatments have been developed to improve patients quality of life. Therefore, reliable diagnostic/prognostic tools are necessary not only for an early diagnosis and for monitoring disease activity, but also for setting up personalized therapeutic treatments.The clinical diagnosis of RA and SLE is assisted by the use of in vitro diagnostic tests aimed at the evaluation of the presence/level of few autoantibodies circulating in serum. Yet, this diagnostic approach is unsatisfactory because it can assist the diagnosis only after the first disease onset, it is not useful to evaluate the disease susceptibility for an early prevention, and it does not provide information to follow the disease progression for the set up of personalized therapeutic treatments.To solve these drawbacks, the GAPAID project is aimed at supplying the SME participants of the scientific and technological activities necessary to develop a novel diagnostic / prognostic platform for patients affected by RA and SLE. To this aim the scientific activities will be focused on the discovery of the diagnostic and prognostic value of the genetic and serological profiles associated to RA and SLE. The technological activities will contribute to develop multiplex arrays for the contemporary detection of more analytes and to set up a software for the RA and SLE diagnosis / prognosis by matching the clinical, genetic, and serological data. The exploitation of the scientific and technological results will allow the SME part