RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hybrid Electronics based on Photosynthetic Organisms' (HyPhOE).

assistant: **Concept**

HyPhOE aims to establish a revolutionary symbiosis between photosynthetic organisms and technology, and to rethink and re-establish the concept of green technology. Photosynthetic organisms are intelligent, with unique functions and capabilities, being able to harvest solar energy, synthesize food, and sequester pollutants. As the boundary between technology and nature is fading, nature is being used as part of the technology and technology is enhancing nature. HyPhOE will be integrated in urban settings, agriculture, and forestry – transforming and elevating our interaction with green organisms tapping into the energy and biochemical cycles of the ecosystem.The ultimate goal of HyPhOE is to develop advanced bio-hybrid systems based on photosynthetic organisms and smart materials and devices. Our strategy relies on developing a set of tools and methods for bi-directional electronic and chemical interfacing with photosynthetic organisms that will comprise the backbone of the project and pave the way for the targeted applications: i. Energy systems based on electronically-functionalized plants and photosynthetic organisms. ii. Plant physiological control using bioelectronics systems. iii. Environmental monitoring using functionalized plants. HyPhOE is divided in 8 work packages that will ensure the smooth workflow towards the achievement of the specific objectives. The members of the consortium will work closely together, complementing each other and bringing expertise from the fields of: chemistry, materials science, (bio-) electronics, electrochemistry, plant biology and ecology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identifying Atherosclerotic Plaques at Risk:  A Microstructure-based Biomechanistic Approach' (MicroMechAthero).

assistant: **Concept**

Atherosclerotic plaque rupture in arteries is the primary cause of cardiovascular events such as heart infarct and stroke, which are responsible for 45% of deaths in Europe. Plaque rupture is a mechanical event, where the collagenous plaque tissue fails to withstand blood pressure loading. Identifying plaques at high risk of rupture is the key to prevent these fatal events. However, the current risk assessment strategy fails to achieve this as it lacks mechanistic insights into tissue failure. To address this unmet, urgent clinical need, I propose a paradigm shift to a biomechanistic risk assessment concept. I will achieve this with MicroMechAthero project, by revealing plaque failure mechanisms and developing a clinically applicable computational risk assessment framework. MicroMechAthero will combine ex-vivo, in-silico, and in-vivo research. Ex-vivo mechanical failure tests on post-mortem human plaque samples will involve tissue's collagen architecture imaging with recently developed polarization-sensitive optical coherence tomography and full-field, local, 3D tissue deformation measurements with digital volume correlation technique. This frontier opto-mechanical approach will revolutionize soft tissue testing and coupled with the virtual fields method, will provide unprecedented data for local, heterogeneous (hyper)elastic and failure properties of fibrous plaque tissue, linked to the underlying collagen network. Furthermore, a microstructure-based, in-silico tissue failure framework will be developed, using eXtended Finite Element Modeling technique, for plaque-specific risk prediction. This computational framework will be validated and tested for its clinical potential in an in-vivo patient study. Overall, MicroMechAthero will provide a ground-breaking advance in o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexibly adapted MetaInnovations, use cases, collaborative business and governance models to accelerate deployment of smart and shared Zero Emission mobility for passengers and freight' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

metaCCAZE accelerates the user-centred deployment of smart systems and services that combine electric automated and connected mobility and related infrastructure across European cities. metaCCAZE organizes a series of MetaDesign activities with multisector-stakeholders and different population groups to develop metadesigned shared zero-emission mobility use cases, collaborative business and governance models. A toolkit called MetaInnovations, is developed consisting of six main smart technologies (1. Align: grid supply-fleet-demand; 2. Harmonise: AI-Datawarehouse; 3. Charge: inductive automated charging; 4. Automate: i. remote control center, ii. Advanced Driver Assistance System; iii. 5. Connect: V2X protocols; 6. Manage & Operate: i. electric vehicle scheduling and demand; 6. Digital twin optimisation). MetaInnovations are pioneered in passenger and freight services (public transport, on-demand mini buses, bike sharing, deliveries) and related infrastructure (mobility and logistics hubs, traffic management centres, charging infrastructure) and widely demonstrated in 4 trailblazer cities (Amsterdam, Munich, Limassol, Tampere). Successful use cases, MetaInnovations and MetaServices are transferred, implemented and demonstrated in 6 follower cities (Athens, Krakow, Gonzo, Milan, Miskolc, Paris region). Demonstrations are monitored to ensure that their impact aligns with the MISSION and SUMP/SULP targets, and that the society embrace them. The MetaSkills Hub is developed and utilizes the lessons learned to deliver a series of cross-sectorial interactive training courses. The MetaPolicy Package is developed to contribute to updates of urban and transport policies and feed the strategic research and innovation agendas (SRIA) of CCAM, 2ZERO and other initiatives. metaCCAZE i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'EASIVIRAL'.

assistant: **Innovation**

In September 2016 WHO-Europe stated “Europe is at a critical point with HIV. New diagnoses in the European Region recently increased by 76%”.  WHO urges “an accelerated people-centered response” based on taking HIV viral-load (VL) testing out of labs and into local clinics where it is most needed at point-of-care (PoC). No such solution exists today.New disruptive innovations are needed to address this. AltraTech Ltd has developed three proven biotechnologies to capture, purify, and detect the HIV virus from a blood sample, in 40 mins, using proven HIV biomarkers. This enables life-saving clinical intervention, immediate prescription and therapy for the patient, and stops further spread of the virus. The three techniques are innovative. Their combination, in a portable battery-operated kit format, is disruptive.  It offers the unique combination of portability, robustness, reduced cost, with simultaneous increase in accuracy, combo-detection of Hepatitis and other viruses, and elimination of refrigerated reagents.  It will address the above crisis, the HIV-VL PoC market, and has the potential to disrupt the €1B viral clinical diagnostics market and displace RT-PCR diagnostics that have been used in laboratories for two decades.   Following a successful SME-Phase-1 feasibility, the technology received a Seal-of-Excellence in Phase-2(PHC-12-2015) – exceeded funding threshold. TRL improvements have been made in 2016, and a new CEO, management structure, and new venture funding significantly enhances AltraTech capacity to commercialise EASIVIRAL and see it reach market acceptance.  The outcomes will enable  capture a market leading share of  > 30% of the €210M PoC HIV-VL market, reach cumulative EBITDA for this product alone of more than €18M by 2024.  AltraTech will create
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmentally responsible air transport' (ERAT), addressing dissemination and exploitation.

assistant: **Impact**

As traffic grows steadily, the environmental impacts of air transport become an increasing problem. The ERAT project is aiming to develop operational solutions that reduce the impact of air traffic on environment in the vicinity of airports. The objective is to minimise noise, emissions and the impact on local air quality due to air traffic in the airport TMA, whilst assuring an increase of or at least no adverse effects on airport capacity.Isolated solutions developed in related research projects such as Sourdine II and OPTIMAL, as well as new new solutions, will be combined into a concept of operations. To accomplish these goals, operational solutions in terms of departure and approach procedures and routing will be developed and evaluated as part of a concept of operations at two European airports. The development of enabling technology is part of this process. The target time frame for the operational implementation of the ERAT proposed concept of operations is 2015 and beyond.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Transcriptional and allosteric regulation of liver carnitine palmitoyl transferase i - l-cpt i- in a non ketogenic mammal'.

assistant: **Concept**

Research objectives and content Carnitine Palmitoyl Tansferase (CPT) system plays a central role in fuel homeostasis since it controls the entry of fatty acids within the mitochondria. CPT I, the outer membrane enzyme of mitochondrial CPT, plays a major role in the activation of Beta-oxidation and ketogenesis after birth. However, in pigs, Beta-oxidation and ketogenesis remain very low during the neonatal period and most of the fatty acids are esterified. In order to elucidate the mechanisms responsible for this peculiar metabolism we plan to study the gene expression of the liver isoform of CPT I (L-CPT I). We will use a previously isolated truncated clone of pig L-CPT I to isolate a full length cDNA and a genomic clone carrying the 5' flanking region of the L-CPT I gene. We will also study the tissue distribution of pig L-CPT I and its expression pattern during development and starvation. In addition we will express the enzyme in eukaryotic cells (COS) in order to determine its sensitivity to malonyl CoA. Finally, the transcriptional regulation of L-CPT I by Peroxisome Proliferator Receptors (PPAR) and cAMP to activate L-CPT I transcription will be studied. Training content (objective, benefit and expected impact) This work will allow us to understand, at the molecular level, the lipid metabolism in a non ketogenic mammal. This study will also provide a better understanding of how the CPT system deals with metabolic destination of long-chain fatty acids. We expect to defend this work as Doctoral Thesis. If we achieve our goals, the data will be submitted for publication. Links with industry / industrial relevance (22) The high mortality of mammalian neonates during early postnatal period remains a significant problem in agricultural sciences. In 1991, the U.S. Departm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Formation and evolution of millisecond pulsars' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Neutron stars allow for fundamental studies in all disciplines of physics in the most extreme regimes - conditions which are impossible to imitate in any laboratory on Earth. The high incidence of binaries (double stars) among millisecond pulsars in combination with rapid spin and relatively weak magnetic fields, strongly suggest a large fraction of them (possibly all) are old neutron stars that have been 'recycled' by accretion of mass and angular momentum from a companion star in a binary system. The objective of my research is to obtain a better understanding of the physics behind the interactions in a compact binary system as well as the dynamics of rotating magnetized neutron stars. The subjects to be investigated include the effects of mass transfer, loss of mass and orbital angular momentum, asymmetric supernova explosions and evaporation of the companion star. Training content (objective, benefit and expected impact) As a postdoc. at CHEAF in Amsterdam, I expect to gain a deeper insight regarding the nature of binary neutron stars from collaboration and discussions with dr. E. P. J. van den Heuvel and co-workers. My work will be theoretical, but it will benefit from the X-ray data obtained from other astrophysicists at CHEAF.Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From mobile phones to court – A complete FORensic investigation chain targeting MOBILE devices' (FORMOBILE), addressing dissemination and exploitation.

assistant: **Impact**

Mobile devices, especially smartphones represent a unique challenge for law enforcement. Criminal offenders use phones to communicate, coordinate, organise and execute criminal actions. This is especially true for organised crime and terrorist organisations. This development provides new challenges for criminal prosecution and it is vital to empower law enforcement to access the data stored on mobile devices to use it as court evidence in a trustworthy and reliable manner.  The overarching objective of FORMOBILE is to establish a complete end to end forensic investigation chain, targeting for mobile devices. To achieve this goal three objectives will be pursued. Novel tools shall be developed that include the acquisition of previously unavailable mobile data, unlocking mobile devices, as well as the decoding and analysis of mobile data. Based on the definition of requirements of law enforcement and legal and ethical issues a new mobile forensics standard shall be developed. With the developments of the new standard and the new tools, training for police and criminal prosecution will be established, providing the end users with the latest knowledge in a novel and an innovative curriculum to ensure a quality standard of investigations.   The European Union has developed as a Security Union, building on the European Agenda on Security. This aims to ensure that people live in an area of freedom, security and justice, without internal frontiers. To strengthen digital forensics in the context of criminal investigations is crucial to achieve this vision. FORMOBILE contributes to the fight against virtually all forms of crime. This is because mobile devices are widely used in crimes, especially in the arrangement of conspiracies. Yet, there are crimes more closely related to mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of fungal conjugate vaccines based on synthetic oligosaccharide structures'.

assistant: **Innovation**

Attempts to prepare conjugate vaccines based on native capsular polysaccharide structures against Cryptococcus neoformans, a fungi increasingly recognized as a major health issue, has been ineffective due to the heterogeneity of the native material. In this project well defined synthetic oligosaccharide structures will be used instead. A library of structures corresponding to native structures will be synthesized and utilized in the production of glycomicroarrays. These will be employed to screen monoclonal antibodies raised against the native polysaccharide to determine their specificity and to identify protective carbohydrate epitopes. Recognized hits will be conjugated to carrier proteins using various spacers and conjugation techniques to produce a selection of vaccine candidates which efficiency will be evaluated in immunizing experiments in mice by collaborators. The training will be multidisciplinary covering complex oligosaccharide synthesis, conjugation techniques, microarray construction, protein and antibody purification and labelling, macromolecular characterisation and biological screening methods. The project is an international collaboration between chemists, immunologists and vaccine industry.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Training Network to improve materials for high-performance, low-cost next- generation redox-flow batteries' (FlowCamp).

assistant: **Concept**

Renewable energy sources like wind turbines require large-scale, stationary energy storage systems to balance out fluctuations in energy generation. FlowCamp will advance the development of one of the most promising storage systems: redox-flow batteries (RFBs). The recruited fellows will develop materials (membranes, electrodes, electrolytes, catalysts, sealing materials) and macrohomogeneous models for three next generation RFBs (hydrogen-bromine, organic and zinc-air systems). They will then upscale the new systems to prototype level (TRL4/5), and validate them using the cutting-edge battery testing facilities available for the prestigious German-funded RedoxWind project at Fraunhofer ICT. The new RFB technologies can be combined in energy storage systems tailored to a wide variety of application scenarios, with lower cost, longer service life and higher efficiency than conventional (e.g. Li-ion) storage devices. Through FlowCamp, 15 ESRs will gain a unique skill-set comprising electrochemistry, material science and cell design/ engineering, as well as an overview of different RFB technologies and their implementation at prototype level. FlowCamp will consequently go far beyond existing electrochemical training, in a field with a high and growing research demand. The employability of the ESRs will be further enhanced by high-quality individualized training in scientific and complementary skills, and a structured network program of training units moving them from theoretical investigations towards industrial application and entrepreneurship. The active involvement of industrial partners, secondments in applied research and industry and a strong research and training emphasis on market requirements will furthermore provide them with the intersectoral experience needed f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modelling and dynamic assessment of integrated health and care pathways enhancing response capacity of health systems' (DYNAMO).

assistant: **Concept**

DYNAMO will result in a lean and powerful solution enabling quick, data-driven and platform-independent planning of care pathways for situations where health system functions are threatened. This solution will allow EU health care systems to build resilience and respond to public health threats better than they can today. DYNAMO brings together five procurers from Italy, Portugal, Spain, Greece and the United Kingdom that not only see the need for such a solution but are willing to act on it now. They will set up a collaborative demand-side initiative to create the economies of scale and early adoption cases required to build momentum for DYNAMO. As a strategic planning tool, DYNAMO will guide stakeholders in concept development, data modelling, process design and implementation planning. DYNAMO will be able to reliably inform medium-term investment planning to adapt existing processes and infrastructures (incl. IT systems). More specifically, DYNAMO will be a socio-technical system to 1. Efficiently adapt service delivery processes to shocks and structural changes2. Share and integrate cross-sectoral data to accurately forecast outcomes and impacts of alternative pathway configurations3. Facilitate task planning and skills matching in times of crisesThe Buyers Group includes health and care organisations and authorities representing diverse health care systems and settings, thus reflecting the requirements of different national health care ecosystems that DYNAMO will have to meet. Suppliers will be rigorously evaluated after each procurement phase, comprising: (I) an Open Market Consultation; (II) specification of architecture and system aligned to requirements of health and care professionals, IT planners, decision makers; (III) prototype development and testing with