RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Transgenic mouse and rat models for alzheimer's disease' under Fourth Framework.

assistant: **Concept**

The proposal aims to develop transgenic mouse and rats as experimental models for Alzheimer's Disease (AD), to study the mechanism of formation and the functional consequences (cellular, tissular and behavioral) of mutations in the Amyloid Precursor Protein (APP) and the Presenilin-1 protein (PS-1). Arguments for a central role of APP in the etiology of AD are: (i) mutations in the APP gene cause severe forms of early onset familial Alzheimer's disease (EOFAD), inherited in an autosomal dominant fashion; (ii) biochemically, APP is the precursor of the ßamyloid peptide, the major constituent of amyloid plaques in the brain of AD patients and (iii) in all Down's syndrome patients (trisomy 21) supporting the hypothesis that overexpression of APP by a gene-dosage effect, or mutations force APP into abnormal metabolic pathways. Abnormal metabolism of APP could result from disturbing its intracellular sorting and/or processing. The very recently demonstrated mutations in the Presenilin genes in different EOFAD cases, identified 2 hitherto unknown genes of unknown function, thereby adding complexity to the problem of AD but also creating a new molecular approach to understand the mechanisms involved in the etiology of AD. By in depth analysis and comparative testing of different APP and PS-1 transgenic mouse and rat strains, the mechanisms underlying neurodegeneration will be delineated. Overexpression of mutant forms of APP and of PS-1 will be done with mini-gene constructs of cDNA using an engineered mouse Thy-1 gene promoter, directing expression of the transgene specifically to the brain in transgenic mice. Two participants are fully operational in generating transgenic mice and rats. Brains of transgenic animals will be analysed molecularly, immunohistochemically and bioc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chronic PAIN eradiCAtion by taRgeting Schwann cElls' (PAIN-CARE), addressing dissemination and exploitation.

assistant: **Impact**

About 25% of the adult population experiences chronic pain, which disrupts daily activities and severely affects the patient’s quality of life. In Europe, the socioeconomic burden of chronic pain runs into billions of euros annually and represents 3–10% of the GDP. The current mainstays of pain treatment are non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, but their prolonged use is frequently associated with life-threatening adverse events and physical dependence. There is therefore an urgent need for new pharmacological strategies with superior efficacy and safety than those of NSAIDs and opioids.PAIN-CARE proposes to address chronic pain signaling using inhibitors targeting the Schwann cell proalgesic pathway. Previous research has shown the crucial role of Schwann cells in sustaining chronic pain. This project aims at developing Schwann cell selective drugs for chronic pain treatment, creating more clinically ready compounds based on bifunctional chimeric antagonists, with an inhibitory activity 100% higher than that of the combination of the two individual antagonists in mouse chronic pain models. The new Schwann Cell selective Analgesic Drugs (SCADs) will provide a dramatic change in the pain treatment paradigm, reducing treatment-related side effects and improving persistence.During this PoC, we aim to identify lead bifunctional chimeric molecules that preferentially antagonise two Schwann cell proteins. We will carry out tests in vitro and in vivo to demonstrate the novel compounds’ feasibility and superior inhibition efficiency when compared to the currently used compounds. Furthermore, our aim is to translate the results to a pre-commercialisation phase through the definition of the innovation commercial feasibility and potential, which will then be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Key Account Management process in EIC pilot activities (Accelerator, FTI/FET-open projects) and enhancing the INnOvation management capacities of SMEs (KAMINO-3)' to be submitted under Horizon 2020.

assistant: **Abstract**

The project aims at boosting the participation of European SMEs in the largest research and innovation funding programme of the EU, H 2020, especially in the EIC pilot activities (Accelerator, FTI/ FET open projects) and as a second at enhancing the innovation management capacities of high innovative SMEs. Furthermore, new SME relevant challenges of the HORIZON Europe Programme (2021-27) will be taken into consideration.Implementation activities are organized in two work packages (WP):Within WP1 Key Account Management (KAM), the project will accompany beneficiaries of the EIC pilot activities (Accelerator, FTI/FET-open projects) in the implementation of their project activities and to initiate a coaching for them. In WP 2 Enhancing Innovation Management Capacity process (EIMC), the project activities should result in significant higher innovation management capacities of SMEs. Therefore, the innovation capacities and processes, innovation strategies and internal organizations as well as their relations with innovation partners will have to be assessed. For this, the partners will apply proven assessment tools. Identified gaps and bottlenecks in the innovation management capacities will be discussed and measures and action plans to overcome them will be defined by the EEN consultants jointly with the SME. KAMINO-3 contains an assistance package for successful applicants in EIC pilot activities (Accelerator, FTI/FET-open projects) of H2020 and delivers assessments, advice and consultations to support SME to strengthen their innovation management capacities. Three EEN partners –ATI Kueste GmbH, Steinbeis-Forschungszentrum and Technologiepark Warnemünde GmbH – work on the mentioned activities. The IHK zu Rostock– will formally act as coordinator but will not implement any t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computional fluid dynamics for combustion', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The efforts of the last ten years of jet engine development has lead to increased pressure and temperature levels of the thermodynamic process in order to increase the engine efficiency. The problems arising from this development is a significant increase in pollutant emissions, especially NOx. The current technology has achieved a status that does no longer allow getting further optimisation without detailed knowledge of the physical phenomena that take place inside the combustor. The combustion process itself is governed by the reactions kinetics, the fuel preparation process, the turbulent fluid flow and the radiative heat transfer to the combustor walls. The main step of the programme is the development of physical models for CFD computations to describe the mentioned physical phenomena. The demonstration of the design criteria can only be achieved by very expensive tests under realistic engine operating conditions. The only method to reduce costs is the reduction of the number of experiments by accompanying the experiments with 3D-calculations of the reacting flow inside the combustor.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The 5th European Conference of the ESMTB on Mathematical Modelling and Computing in Biology and Medicine' under Fifth Framework.

assistant: **Concept**

Mathematical and theoretical biology and medicine is a diverse field in which interdisciplinary collaboration is essential for progress. The field ranges from experimental research linked to mathematical modelling to the development of more abstract mathematical frameworks in which observations about the real world can be interpreted and with which new hypotheses for testing can be generated. The medical, industrial and social interests in the development of this research field is undisputable. Insights and predictions from mathematical modelling are used increasingly in decision support in medicine (e.g. immunology and spread of infectious diseases, cancer research, cardio-vascular research, neurological research, optimisation of medical treatments, imaging), and enviromental nature management, climate problems, agriculture and management of natural resources.Fast developments in areas such as biotechnology (e.g. genome projects, genetic modification) continue to add new focal points of activity to the field. The European Conference on Modelling and Computing in Biology and Medicine has as its goal to foster interdisciplinary collaboration between mathematicians and bioscientists and to act as the main forum for the exchange of recent research results and new research directions to the widest possible community in theoretical biology and medicine.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00149-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving medical treatment adherence : taking into account patients' perception of uncertainty in the causal relationship between their adherence behaviour and their health condition' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Non-adherence, defined as the discrepancy between patients' behaviour and medical prescriptions, is a massive public health issue, the consequences of which are serious. Nearly half of the patients who have a chronic disease do not take their treatment as prescribed. In order to improve our understanding of this phenomenon and to remedy it, the proposed research will examine following hypothesis : in the case of long-term conditions for which a treatment is effective and has little side effects, a cause of intentional non-adherence could be that (1) the patients perceive or, in a way, create, different types of uncertainty regarding the causal relationship between their treatment and their health and that (2) they consider that this uncertainty makes the case for non-adherence. This assumption is based on patients' adherence behaviour that I evidenced in previous research on cystic fibrosis and Wilson's disease. The proposed research will consider 4 disorders and 5 treatments that are : chronic myeloid leukemia treated with imatinib, Parkinson's disease treated with dopamine agonists and by L-DOPA, diabetes 2 treated with metformin and hypertension treated with antihypertensive treatments. The inquiry will proceed in three steps, that aim at (1) understanding the phenomenon through a qualitative study (focus groups and interviews), (2) designing an intervention based on this understanding, through an interventional study, in order to reduce the phenomenon and (3) at validating empirically the effectiveness of the intervention, through a quantitative study. The proposed research matches the first goal of the Horizon 2020 programme for a Better Society. It is at the intersection of 3 academic disciplines: (1) sociology of health, (2)  psychology of risk perception and beh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Global information system for the fight against counterfeiting'.

assistant: **Concept**

The project consists in creating a tool for the access to reliable and up-to-dated information in the domain of the Intellectual Property Right, Counterfeiting and Technical Protection. All the information will be extracted from existing public or private databases. This infrastructure will be the support for a European network of single points of contact (or Euroguichets"). Three kinds of users are targeted:1. The industry: the platform will provide access to Research Institutes or Companies dealing with authentication methods. Right Holders will be able to present their needs and obtain different industrial responses. On the reverse, Companies dealing with authentication will be able to faster disseminate the results of their works in this domain.2. The Enforcement Agencies: the platform will provide them with personal data on defrauders whose names are stored in private or public databases.3. The Consumers (but also judges, prosecutors, inventors, students...): the platform will deliver information about Intellectual Property Rights, Counterfeiting and its harmfulness, legal procedures of registrations and Courts decisions.At the end of the project, the service will be managed by a Services Operator."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design and assessment of global, european and regional scale UV irradiance maps based on satellite data and ground measurments.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The main objective of MAUVE is to establish maps of surface W radiation, derived from satellite data, as a recognised source of information for a variety of applications including trend studies, documentation of potential environmental changes and risks assessment for human health. Only satellite derived W maps can provide the needed global and synoptic information. Indeed, although the ground network of instruments will always retain its reference role in terms of accuracy, its density is and will remain limited, even in Europe but evidently in less favoured areas of the world. However, the use of satellite derived maps of surface W radiation is presently impaired by their poorly assessed accuracy. Therefore, key tasks in MAWE are to improve the existing products, customise them to the users needs and validate them against reference ground measurements. The MAUVE products will be based on methodologies developed in the framework of several national ongoing activities. The Institutes conducting these projects are Partners in MAWE and aim at integrating their approaches into two validated products: global and high spatial resolution. Five of the MAUVE Partners are also future users of the surface UV radiation maps and other end users are associated to the project. A goal in terms of accuracy is not easy to define because the achievable result will depend on the meteorological conditions (clouds, aerosols) and other environmental factors such as e.g. the presence of snow. The accuracy will also be very different for instantaneous observations or, for instance, monthly averages. Therefore, instead of trying to define the products on an abstract basis and risking to issue requirements which will rapidly prove to be impossible to fulfil, the project starts by building and as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Inspired to Integrate: Filtering Nature's Diversity for Nature-friendly Implementations' to be submitted under Horizon Europe.

assistant: **Abstract**

Nature provides an almost inexhaustible source of inspiration for innovative designs that may help to tackle many of the world’s current social, economic and environmental challenges. In accordance, the potential of bioinspiration (including biomimetics and biomimicry) has become widely recognized in academia and industry. The main hurdle preventing the field of bioinspiration from delivering its promises, however, stems from differences in tools, practices and viewpoints of its practitioners, often obstructing further development towards successful products. Nature4Nature, a unique joint effort of biologists, engineers, designers and manufacturers, will immerse early stage researchers (ESRs) in a learning environment that fully spans the inspiration, integration and implementation aspects of bioinspired design to tackle the conceptual, methodological and practical challenges. It will provide ESRs (a) with a mindset and know-how to harness biodiversity into design; (b) with the theoretical background and practical skills for transferring biological model systems into engineering designs and applications; and (c) with an attitude and competence to implement bioinspired ideas in an explicit sustainable way. Nature4Nature will focus its research activities onto one model system: how to efficiently separate solid particles from liquids. Biological filtration systems have evolved repeatedly over the earth’s living history. Nature4Nature will teach ESRs to make the most of this rich heritage, using it as an inspiratory source for designing and manufacturing high-throughput, clog-resisting filtering systems that can help conserving and restoring the world’s aquatic habitats. By fostering a new generation of researchers operating at the interface between scientific disciplines,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Products by Rapid Integrated Detailed Engineering' in the context of a Fourth Framework call.

assistant: **Objectives**

The development of the PRIDE prototype hybrid object modeller resulted in the preparation of a set of software tools that will collaborate to support the detailed engineering for manufacture of complex castings and other parts in the following areas:- detailed modelling of incompletely specified areas, including using data digitised from physical models;- preparation of representations for analysis and manufacture;- adjustment of detailed models to meet performance and manufacturing criteria;- prototype manufacture for form/fit and performance testing.In addition a methodology for the testing and adjustment of designs to improve/optimise performance and quality of the part or the manufacturing process was developed. Furthermore the project contributed to the development and testing of the DMAC OLE for D&M standard industry technology for the integration of computer aided design and modelling applications.In detail the PRIDE Hybrid Object Modeller resulting comprises:a) background commercial CAD,CAM CAE and simulation software that was ported to the Microsoft Windows environment;b) DMAC industry standard interface software that was developed and integrated into the CAD,CAM CAE and simulation software to provide the key server and client applications needed for the PRIDE domain;c) additional software written and integrated into the background commercial CAD,CAM CAE and simulation software to tackle the bottleneck issues identified by the industrial application experts in the Consortium.The world wide competition for the supply of engineering components makes competitiveness in terms of product functional performance and lead time a critical survival issue for many European companies. This has led manufacturers of complex engineering castings and mouldings to develop a str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Trans* and Gender Non-Conforming Migrant Experiences in South America'.

assistant: **Concept**

This innovative, multi-methods project investigates how Transgender and Gender Non-Conforming (TGNC) migrants in South America navigate overlapping borders in their pursuit of safety and access to rights. While existing research on trans+ migration often focuses on South-North migration, this study centers South-South mobility, examining the experiences of Paraguayan and Venezuelan TGNC migrants in Brazil, a key destination due to its relatively progressive laws yet persistent violence against LGBTQ+ communities. Drawing on Necropolitics as a theoretical framework, the project interrogates how state and societal practices of exclusion, abandonment, and violence delineate the conditions under which TGNC migrants are allowed to live, or left to die. Through participatory methods, the study documents how TGNC migrants make sense of their journeys across national and gendered borders, how necropolitical violence shapes their mobility and daily lives, and how they sustain care networks despite fractured geographies. By focusing on South-South migration, this research challenges Global North-centric queer mobility studies and offers new frameworks for understanding survival and community-making among marginalised migrants. The project contributes to debates on borders, gender, and agency while amplifying TGNC voices often erased in policy and academia.