RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An european spraying advisory system for the potato disease control by using geo-information' in the context of a Fifth Framework call.

assistant: **Objectives**

Potato late blight (Phytophthora) causes significant losses amongst the European potato growers. To win the battle against this very infectious disease, potato growers use significant amounts of fungicides as a precautionary measure. From an environmental and economical point of view it is important to optimise spraying activities. DACOM has set up a spraying advisory service to farmers through internet services; the Plant Plus system. On the basis of weather information, the presence of infection sources, etc the farmers are advised when to spray. In support of the control of Phytophthora disease there is clear need of additional spatial related information to improve, support and extend the spraying service. We propose to formulate a RTD proposal how the current spraying advisory service can take advantage of the expertise in the field of earth observation, GIS and Internet providing services in the end to develop an improved spatial prototype of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Design, synthesis and biological studies of novel 1,4-benzoxazepines as antitumour compounds'.

assistant: **Objectives**

Breast cancer remains the most common cancer in women and is the most frequent cause of cancer death. Over the past 20 years, the 5-year survival for patients with breast cancer has increased by around 10%, largely as a result of earlier diagnosis and better treatment. Nevertheless, 5-year survival rates for people with breast cancer range between 60% and 70%, and many patients still die from the disease. Although 5-fluorouracil (5-FU) was first introduced in 1957, it remains an essential part of the treatment of a wide range of solid tumours. Although this antimetabolite is toxic, its efficacy makes it one of the most widely used agents against solid tumours. 5-FU-containing acyclonucleosides have been reported to induce myogenic differentiation in rhabdomy osarcoma cells, suggesting that these drugs might be useful for differentiation therapy in this type of tumour. Such a therapy is an attractive approach to cancer treatment, which assumes that neoplastic transformation reveals the inability of a cell popul ation to couple proliferation and differentiation signals. Following these results a series of 1,4-benzoxazepines linked to natural or synthesised bases is proposed. A library of compounds will be synthesized in solid phase to rapidly obtain the maximum structural variety. The compounds will be tested as in vitro antiproliferative, apoptotic and cell cycle drug-acting agents against breast cancer. Biological studies will be carried out to determine the mechanism of action at the molecular level. QSAR, SAR and molecular modelling studies will be developed throughout the project. The information obtained from these structure-activity relationships will be valuable to determine which parts of the synthesized molecules are essentially involved in the activity and pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Confronting Obesity: Co-creating policy with youth' (CO-CREATE) targeting Horizon 2020.

assistant: **Abstract**

CO-CREATE aims to reduce childhood obesity and its co-morbidities by working with adolescents, to create, inform and disseminate obesity-preventive evidence-based policies. The project applies a systems approach to provide a better understanding of how factors associated with obesity interact at various levels. The project focus on adolescence as the specific target group, a crucial age with increasing autonomy and the next generation of adults, parents and policymakers, and thus important agents for change. CO-CREATE involve and empower adolescents and youth organizations to foster a participatory process of identifying and formulating relevant policies, deliberating such options with other private and public actors, promoting relevant policy agenda and tools and strategies for implementation. CO-CREATE strengthen interdisciplinary research and have an inclusive multi-actor approach with involvement of academics, policy makers, civil society, relevant industry and market actors to ensure long-lasting implementation of the results. The project reflects and builds on a number of existing initiatives and platforms, including the extensive research activity from consortium members. The project has a strong gender profile and consider the relevance of geographic, socio-economic, behaviour and cultural factors. CO-CREATE engages international partners from different policy-contexts in Europe, Australia, South Africa and the US.  Applying large-scale datasets, policy monitoring tools, novel analytical approaches and youth involvement will provide new efficient strategies, tools and programmes for promoting sustainable and healthy dietary behaviours and lifestyles. The generated knowledge and innovative tools for assessing actual policy implementation, strategies for empowerin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Knowledge and manipulation of nature between usefulness and deception in the Arabo-Islamic tradition (9th-15th century)' under Horizon Europe.

assistant: **Concept**

The UseFool project studies the knowledge and manipulation of nature applied to entertainment and fraud, as described in the Arabic technical literature dealing with the practice of charlatans and performers along the streets and in the markets. At the core of UseFool’s textual corpus are four Arabic handbooks composed between the 6th/12th and the 9th/15th century, combined with other sources, such as the handbooks for the inspector of the market that focus on artisanal impostures. The project will reconstruct the refined technical notions mastered by marginal social groups, showing how the lightly dismissed ‘popular knowledge’ was actually a form of ‘street science’. The project’s goal is to write a new chapter in the cultural, social, and material history of knowledge looking through the lens of Arabic technical literature. UseFool proposes a new interdisciplinary approach to its sources: this begins from a philological and textual analysis that focuses on their technical contents, expands to the reconstruction of the material dimension of the procedures through hands-on replication, and completes its all-round approach with the re-enactment of the performative and theatrical dimension entailed in the different forms of deception. In this way, UseFool will assess the interaction between the narrative component and actual practice in this textual tradition. The project will also map the sources of this technical literature on deception, in order to reconstruct lines of transmission in a long time span and across different cultures. The project reflects on the roots of the handbooks on entertainment and fraud in the antique and late antique heritage, with the aim of providing a searchable and organized structure to the lore of natural properties. UseFool also expands it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Antibiotic resistance genes in the environment: a comprehensive, multi-phasic survey of prevalence and transfer' (1994-1998).

assistant: **Concept**

The widespread use of antibiotics has resulted in the rapid dissemination of antibiotic resistance genes amongst bacterial populations. Little is known about the natural reservoir for such resistance genes and how resistance is disseminated in non-clinical environments. The comprehensive survey of the prevalence, distribution, mobility and selection of antibiotic resistance genes within bacterial populations is the major objective of this proposed study. Three antibiotics, gentamicin, streptomycin and tetracycline will be used to select for phenotypic resistance in culturable populations. Published sequence data for resistance genes will be used as a data base for molecular studies to enable the design of probes and primers for PCR screening. The focus of the study will be on discrete genes responsible for antibiotic modification, efflux or ribosome protection. DNA will be extracted directly from all samples using standardized protocols and used for PCR screening to detect the most prevalent genes. Dominant PCR products will be sequenced and sequences compared to the database. This will provide optimized probes and primers for screening the cultured bacteria. In addition, a comprehensive study will be undertaken in the same samples to determine the presence of the actinomycetes responsible for production of the three antibiotics or closely related compounds. Again a phenotypic and genotypic approach will be taken. The potential for transfer and evidence of mobility will be obtained by exogenous isolation of resistance genes on plasmids or tranposons in marked recipients, obviating the need for culture. The resulting transconjugants will be screened for key genes. Finally each participant will focus on a specific environment to investigate environmental impacts on resist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DNA traffic during bacterial cell division' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The molecular mechanisms that serve to couple DNA replication, chromosome segregation and cell division are largely unknown in bacteria. This led a considerable interest to the study of Escherichia coli FtsK, an essential cell division protein that assembles into DNA-pumps to transfer chromosomal DNA between the two daughter cell compartments during septation. Indeed, our recent work suggests that FtsK might regulate the late stages of septation to ensure DNA is fully cleared from the septum before it is allowed to close. This would be the first example of a cell cycle checkpoint in bacteria.FtsK-mediated DNA transfer is required in 15% of the cells at each generation in E. coli, in which it serves to promote the resolution of topological problems arising from the circularity of the chromosome by Xer recombination. However, the FtsK checkpoint could be a more general feature of the bacterial cell cycle since FtsK is highly conserved among eubacteria, including species that do not possess a Xer system. Indeed, preliminary results from the lab indicate that DNA transfer by FtsK is required independently of Xer recombination in Vibrio cholerae.To confirm the existence and the generality of the FtsK checkpoint in bacteria, we will determine the different situations that lead to a requirement for FtsK-mediated DNA transfer by studying chromosome segregation and cell division in V. cholerae. In parallel, we will apply new fluorescent microscopy tools to follow the progression of cell division and chromosome segregation in single live bacterial cells. PALM will notably serve to probe the structure of the FtsK DNA-pumps at a high spatial resolution, FRET will be used to determine their timing of assembly and their interactions with the other cell division proteins, and TIRF wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Symbiotic Evolutionary Robot Organisms' (SYMBRION).

assistant: **Concept**

The main focus of this project is to investigate and develop novel principles of adaptation and evolution for symbiotic multi-robot organisms based on bio-inspired approaches and modern computing paradigms. Such robot organisms will consist of super-large-scale swarms of robots, which can dock with each other and symbiotically share energy and computational resources within a single artificial-life-form. When it is advantageous to do so, these swarm robots can dynamically aggregate into one or many symbiotic organisms and collectively interact with the physical world via a variety of sensors and actuators. The bio-inspired evolutionary paradigms combined with robot embodiment and swarm-emergent phenomena, enable the organisms to autonomously manage their own hardware and software organization. In this way, artificial robotic organisms become self-configuring, self-healing, self-optimizing and self-protecting from both hardware and software perspectives. This leads not only to extremely adaptive, evolve-able and scalable robotic systems, but also enables robot organisms to reprogram themselves without human supervision and for new, previously unforeseen, functionality to emerge. In addition, different symbiotic organisms may co-evolve and cooperate with each other and with their environment.The extraordinary potential and capability of autonomous large-scale symbiotic self-aggregation, reprogramming and evolution would open-up a wide range of current and future applications. The main application scenarios of such artificial organisms would be human-free environments with a high degree of danger or uncertainty as e.g. hazardous or space environments. The consortium represents leading organizations in different research fields and provides the critical mass of expertise an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Fundamental hydraulic research for coastal areas by using large-scale facilities of the hydro-lab-cluster north germany'.

assistant: **Concept**

Description:Supported by the European Community the Franzius-Institute for Hydraulic, Waterways and Coastal Engineering of the University Hannover offers Fundamental Hydraulic Research for Coastal Areas by using Large-scale Facilities of the Hydro-Lab-Cluster North Germany under the Enhancing Access to Research Infrastructures action of the Improving Human Research Potential and the Socio-economic Knowledge Base programme of the Fifth Framework Programme of the European Community. Within the infrastructure, entitled Hydro-Lab-Cluster North Germany, access will be provided to three physical modelling facilities for large-scale experiments (2-D Wave Channel Schneiderberg, 3-D Wave Basin Marienwerder and Restricted-Water Ship Towing Tank Marienwerder) and to Computer Facilities for Numerical Simulations offering the absolutely state-of-the-art and rather rare opportunity in the European Community to combine physical and numerical modelling in the field of hydraulic (e.g. water inlet structures), waterways (e.g. ship operation on rivers) and coastal engineering (e.g. wave loads on structures) at the same time.Application:Users applying for access to the Hydro-Lab-Cluster North Germany are required to submit proposals to the Franzius-Institute for Hydraulic, Waterways and Coastal Engineering of the University Hannover. General conditions for participation and guidelines for proposals can be found on the Internet at http://www.fi.uni-hannover.de/proj99/TNA.html and/or will be specified upon request to the Franzius-Institute for Hydraulic, Waterways and Coastal EngineeringPostal address: Att.: Dr.-Ing. Andreas Ma-theja, Nienburger Strasse 4, 30167 Hannover - Germany;Tel: +49-511-7623738e-mail: am@fi.uni.hannover.de.Project Manager:Claus Zimmermann, Franzius-Institut for Hydrau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Synthetic platforms for ad libitum remodelling of yeast central metabolism'.

assistant: **Innovation**

Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities. The efficiency of such engineered microbes strongly depends on their native metabolic networks. However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance. As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their function, are scattered over the genome and chromosomes. This absence of a modular organization tremendously restricts genetic accessibility and presents a major hurdle for fundamental understanding and rational engineering of central metabolism. To conquer this limitation, I introduce the concept of ‘pathway swapping’, which will enable experimenters to remodel the core machinery of microbes at will.Using the yeast Saccharomyces cerevisiae, an industrial biotechnology work horse and model eukaryotic cell, I propose to design and construct a microbial chassis in which all genes encoding enzymes in central carbon metabolism are relocated to a specialized synthetic chromosome, from which they can be easily swapped by any –  homologous or heterologous – synthetic pathway. This challenging and innovative project paves the way for a modular approach to engineering of central metabolism.Beyond providing a ground-breaking enabling technology, the ultimate goal of the pathway swapping technology is to address hitherto unanswered fundamental questions. Access to a sheer endless variety of configurations of central metabolism offers unique, new possibilities to study the fundamental design of metabolic pathways, the constraints that have shaped them and unifying principles for their structu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nuclear Dynamic, Organization and Genome Stability' (NDOGS).

assistant: **Innovation**

The eukaryotic genome is packaged into large-scale chromatin structures occupying distinct domains in the cell nucleus. Nuclear compartmentalization has recently been proposed to play an important role in genome stability but the molecular steps regulated remain to be defined. Focusing on Double strand breaks (DSBs) in response to which cells activate checkpoint and DNA repair pathways, we propose to characterize the spatial and temporal behavior of damaged chromatin and determine how this affects the maintenance of genome integrity. Currently, most studies concerning DSBs signaling and repair have been realized on asynchronous cell populations, which makes it difficult to precisely define the kinetics of events that occur at the cellular level. We thus propose to follow the nuclear localization and dynamics of an inducible DSB concomitantly with the kinetics of checkpoint activation and DNA repair at a single cell level and along the cell cycle. This will be performed using budding yeast as a model system enabling the combination of genetics, molecular biology and advanced live microscopy. We recently demonstrated that DSBs relocated to the nuclear periphery where they contact nuclear pores. This change in localization possibly regulates the choice of the repair pathway through steps that are controlled by post-translational modifications. This proposal aims at dissecting the molecular pathways defining the position of DSBs in the nucleus by performing genetic and proteomic screens, testing the functional consequence of nuclear position for checkpoint activation and DNA repair by driving the DSB to specific nuclear landmarks and, defining the dynamics of DNA damages in different repair contexts. Our project will identify new players in the DNA repair and checkpoint pat