RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rock Hyrax Middens and Climate Change in Southern Africa during the last 50,000 years' (HYRAX).

assistant: **Concept**

In stark contrast to the abundance of high quality palaeoenvironmental records obtained from the temperate regions of the northern hemisphere, terrestrial palaeoenvironmental information from southern Africa's drylands comes from discontinuous deposits with poor absolute age control and ambiguous palaeoclimatic significance. Confronted with the possibility of future environmental and social disruption as a result of climate change, the need for reliable records from southern Africa has never been so acute. This project seeks to develop rock hyrax middens as novel palaeoenvironmental archives to investigate long-term climate change. Hyrax middens (fossilised accumulations of urine and faecal pellets) contain a range of palaeoenvironmental proxies, including fossil pollen and stable isotopes. As part of a pilot study, I have created new collection and sampling methodologies, establishing the proof of principle and showing that middens provide continuous sub-annual to multi-decadal multi-proxy records of environmental change spanning the last 50,000 years. This work has been exceptional in terms of its ability to elucidate long-term climate dynamics at the local scale, and I now intend to apply my techniques to studying environmental change across the whole of southern Africa, a climatically sensitive, but poorly understood region of the globe. Developing new sites, proxies and analytical techniques, HYRAX will provide the first opportunity to study rapid climate change events, the extent and phasing of major climatic phenomena, and the direction and potential impacts of future climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An accurate plasticity model of texture, strain-path induced anisot ropy and forming limits for computer aided sheet metal forming' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives and content The objective of this basic research project is to develop a constitutive model of the plastic behaviour of metal sheet, taking into account its most relevant aspects for single and multi-stage stamping operations. Existing advanced plasticity models of texture and strain-path induced anisotropy will be further developed into an original unified model which captures the influences of the microscopic physical mechanisms that govern the macroscopic plastic behaviour, i.e. crystallographic textures and dislocation structures. This constitutive model will also be used to develop forming limit criteria for reliable predictions of possible sheet necking failures during multi-stage forming. The resulting models will be of vital importance for the development of accurate finite element tools for virtual product development of all kinds of sheet metal parts in, e.g., automotive, canning, aerospace, and white-ware" industries. Sheets of different types and qualities will be selected from the commercial production of steel and aluminium sheet companies. Detailed experimental studies will be carried out to fully characterise their crystallographic textures, hardening behaviour upon strain-path changes and forming limits after complex strain paths. A unified model of texture and strain-path induced anisotropy will be developed and extended for strain-rate sensitivity. A complete experimental test procedure for the determination of the material parameters will be defined. Forming limit criteria for the prediction of necking failure during complex strain-paths will be developed based on the unified constitutive model. For validation purposes, the constitutive and forming limit models will be integrated into existing finite element codes for the simulation of she
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulation of innate immunity in the female reproductive tract' (RIIFERT) targeting Seventh Framework.

assistant: **Abstract**

Implantation failure after natural mating or in vitro fertilization may be due to either embryo or endometrial factors. Recent evidence suggests that sub-clinical infection, inflammation or malfunctions of the immune system in the female reproductive tract (FRT) are major causes of implantation failure. Toll like receptors (TLRs) have been shown to have a key role in the induction of immune and inflammatory responses in mammals. TLRs are the main family of pattern recognition receptors, they recognise pathogen-associated molecular pattern and constitute a major part of the innate immune system. We have demonstrated the presence and distribution of TLRs in the human FRT and we have also reported cyclical expression of TLRs during the menstrual cycle in the human endometrium. TLRs expression and function is also affected by sex hormones in endometrial cell lines. Finally using in vitro assays of human implantation, it is clear that activation of TLR5 leads to a reduction in binding of human trophoblast cells to endometrium. Indicative of the role that this molecule plays in mediating human implantation process. We aim to systemically investigate the effect of sex hormones on expression and function of TLR5 in Human endometrial cells. We hypothesise that alteration of sex hormones in the environment of endometrial cells will result in alterations of TLR5 expression and function. Using a TLR5 gene-reporter system, TLR5-eGFP system and microfluditics we aim to construct an in vitro model for systemic analysis of TLR5 gene expression, protein production and function in endometrial cells in the presence of different combinations and concentrations of sex hormones. Data obtained will be used to establish an in silico model to predict alterations in expression and function of TL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Emerging Simplex ORigins In ALS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

My aim is to understand the exact genetic contribution in every patient with Amyotrophic Lateral Sclerosis (ALS), a lethal disease with a life time risk of 0.3% and an urgent unmet therapeutic need. I have recently shown a disproportionate large contribution from low-frequency genetic variants in ALS. ALS is not simply a collection of unique rare diseases with a monogenetic cause nor is it a diagnostic continuum with a complex contribution of thousands of small effect factors. ALS is in-between, which I call “simplex”, where in each patient a few, considerably strong genetic factors with or without environmental factors are at play. ALS mutations are characterized by reduced penetrance, variable clinical expressivity, have specific pleiotropic clinical features and interact with environmental factors. These phenomena are unexplained, but provide me with important and new opportunities in order to unravel the clinical, genetic and biological heterogeneity in ALS. I have created new research fields to go an important step beyond the state of the art: Splitting by lumping uses novel machine learning algorithms to reclassify patients using clinical pleiotropic features, environmental factors and blood epigenetic profiles to identify novel ALS mutations. Imaging genomics overlays patterns in ALS-associated brain morphology on MRI with brain gene-expression patterns to find ALS mutations. ALS risk in 3D integrates data on three-dimensional folding of DNA with genetic data to identify causal mutations and mutation-to-mutation interaction. ALS genomic modifiers in 3D identifies modifiers of C9orf72 mutations through the development of cellular reporter assays and CRISPR-Cas9 based screens. Genomic findings are translated using cellular models which can be used for targeted and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'employing protein aggregation as an antibacterial design strategy' (PeptIn), addressing dissemination and exploitation.

assistant: **Impact**

Antibiotic resistance is increasing globally at such a pace that many experts fear the dawn of the post-antibiotic era if we fail to meet the urgent need for novel therapeutics. We evaluated if the working hypothesis of the MANGO ERC project that protein aggregation is driven by sequence specific interactions can be exploited to generate aggregates that are specifically toxic to bacteria without affecting mammalian cells. In particular we examined if peptides encoding aggregation-prone sequence segments of bacterial proteins can display antimicrobial activity by initiating aggregation in bacteria but not in mammalian cells. Unbiased in vitro screening of aggregating peptides lead to the identification of several hits that are strongly bactericidal against drug resistant gram+ S aureus strains, and others against pathogenic gram- E coli strains. The peptides cured mice from bacterial sepsis without apparent toxic side effects. The peptides enter and accumulate in the bacterial cytosol where they cause aggregation of bacterial polypeptides and the formation of inclusion bodies. Although the precise chain of events that leads to cell death remains to be elucidated, the ability to tap into aggregation-prone sequences of bacterial proteomes to elicit antimicrobial activity represents a rich and unexplored chemical space to be mined in search of novel therapeutic strategies to fight infectious diseases that are increasingly threatening global healthcare. However, given the novelty of this concept, the viability of aggregating peptides as antimicrobial therapeutics needs to be further advanced in order to consolidate the already significant interest from the pharmaceutical industry. In the current proposal we outline a series of experiments designed to address some of the key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Securing Europe through Counter-Terrorism—Impact, Legitimacy and Effectiveness""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project aims to create an empirically-informed view of the legitimacy and effectiveness of European security legislation, taking into account legal, societal, operational and democratic perspectives. It aims to produce an interdisciplinary and multi-stakeholder understanding of mechanisms for measuring the impact, legitimacy and effectiveness of legal measures, connecting theoretical and practical perspectives with a sound and operationally-informed analysis of these measures in practice. In this way it aims to identify the strengths, weaknesses, assumptions and dissonances across and between existing theoretical, institutional and operational perspectives.The strategic approach of the project is to create dynamic synergies between the legal, sociological and ethical disciplines, authorities and end users in order to generate a holistic understanding of the operation of European legal measures from the perspective of impact, legitimacy and effectiveness. We will do this through the use of both inter-disciplinary desk research and, vitally, concentrated engagement with end user groups in in-depth case studies in order to bridge the gaps in understanding between theoretical and legal perspectives, on the one hand, and operational and practical needs on the other.This project will enable the generation of better mechanisms to assess the legitimacy of legal instruments, for Security, in the context of both efficacy and societal acceptability providing both European and national authorities and implementing bodies with an operable perspective to be applied in designing, implementing, transposing and assessing such security measures. This will improve the overall effectiveness and legitimacy of European security measures and their implementation within and across member
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'In-situ generation of chemicals for improved treatments of oil and gas wells' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The goal of this research project is to devlop novel high performance chemical treatments for oil and gas wells. These will be based on in-situ production of specific chemicals to achieve specific effects within the oil or gas bearing rock formation. Research is required to : - develop systems for in-situ production of the desired chemicals; - test these new systems in specialised laboratory rock core testing equipment; - model field tracks using oilfield simulation software. The goal of this research project is to devlop novel high performance chemical treatments for oil and gas wells. These will be based on in-situ production of specific chemicals to achieve specific effects within the oil or gas bearing rock formation. Research is required to : - develop systems for in-situ production of the desired chemicals; - test these new systems in specialised laboratory rock core testing equipment; - model field tracks using oilfield simulation software.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Electronics Enabling Efficient Energy Usage'.

assistant: **Objectives**

E4U aims at fostering world-leadership in ICT enabled energy efficiency in the EU through accelerating research and development for energy-efficient ICT systems. It will achieve this through the creation of a strategic research roadmap for power electronics in alignment with the national, EU, and international policy framework. E4U will create impact through targeted interaction with the research community, leading European industry, and RTD policy makers at the national and European level. E4U will also advertise the benefits of power electronics and ICT for energy efficiency to the broad public.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Perturbations, stability and Hawking radiation of higher dimensional black holes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We propose a detailed investigation of the gravitational stability and emissionof Hawking radiation of diverse higher-dimensional black hole solutions motivatedby string theory and higher dimensional gravity.The applicant aims at the complete classification of higher-dimensional black holesaccording to their gravitational stability. In addition, we plan to make further investigation of possible correlationsbetween gravitational and thermodynamical instabilities in such systems, and, to check if there is a correlation between gravitational instability and existence of closed time-like geodesics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NEST–care: meNtal hEalthcare Service neTworking solutions' (NEST-Care) under Horizon Europe.

assistant: **Objectives**

People with mental illness may suffer a deterioration of their condition and develop a severe mental disorder, alongside other collateral factors such as eating disorders, sleep disturbance, risky sexual behaviours, but also lack of care and support from family and friends, disability employment and financial deficiency. When it comes to creating positive change, relevant health care services should call for better coordinated action. Collaborative care settings imply the coordination of health service providers in creating a holistic plan of care that promotes healthy choices and develop a well-connected support system that incorporate patients social and environmental contexts. However, creating synergies towards healthcare integrated solutions among different set of players in healthcare is complex. Community health centres, pro bono clinics, private foundations, not-for-profit organisations, etc., have different needs, capabilities, and priorities that non necessarily converge. Is it possible to predict and facilitate the emergence of partnerships among different mental health services? Which factors nurture trustworthy relationships and sustain collaboration? How their networking performance and collective action can be evaluated? These questions have been insufficiently examined because, the analysis of multilevel collaborative processes (i.e., referrals, resource sharing, joint interventions and campaigns, as well as trust relationships and affiliations between public and private service providers and key personnel) has yet to be undertaken. Using the Catalonias example as case study of co-governance approach for mental health, and rooted in network science and multilevel network analysis, this project seeks to understand and map health providers partnerships and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Low power high image quality display using colour sequential display technology' (GREEN), addressing dissemination and exploitation.

assistant: **Impact**

There is growing awareness that our hunger for energy has a large impact on the environment. A significant amount of energy is consumed by electronic devices that we use. In Europe we consume 210,000 MWh a day watching TV. In China, power consumption will increase dramatically in the future. Liquid Cristal Display (LCD) is the major display technology for the coming 10 years. Although LCDs offer many benefits, they provide a relatively poor system solution in terms of power-efficiency. Unfortunately, the LC panel efficiency is limited to 5-7%. A good solution to reduce the power consumption is to remove the colour filters and generate the colour temporally. First prototypes have shown this successfully, but they suffer from severe colour breakup artefacts. The focus of the research carried out in this proposal is to find solutions that suppress colour breakup without the need for unrealistically high refresh rates. The hosting party published some first results using a 120 Hz colour sequential system with two colour filters and two colour fields. Although the colour break-up is reduced, it remains well visible for certain important classes of images. In the literature also other methods are described that could reduce the colour breakup, but they were unsuccessful to eliminate the colour breakup. IIF candidate,Y. Zhang, will develop new algorithms that drive the backlight and the panel in such a way that the colour breakup is reduced to an acceptable level. The hosting party also has excellent facilities for perception research and video processing development and testing, and has the hardware or the facilities to build the hardware required to study and test the colour breakup phenomenon. This project offers a unique opportunity to foster and further strengthen the exi