RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mesenchymal Cells of the Lamina Propria in Intestinal Epithelial and Immunological Homeostasis'.

assistant: **Objectives**

Mesenchymal cells (MCs) of the intestinal lamina propria refer to a variety of cell types, most commonly intestinal myofibroblasts, fibroblasts, pericytes, and mesenchymal stromal cells, which show many similarities in terms of origin, function and molecular markers. Understanding the physiological significance of MCs in epithelial and immunological homeostasis and the pathophysiology of chronic intestinal inflammatory and neoplastic disease remains a great challenge.In this proposal, we put forward the challenging hypothesis that, especially during acute or chronic inflammatory and tumorigenic conditions, MCs play important physiological roles in intestinal homeostasis regulating key processes such as epithelial damage, regeneration and tumorigenesis, intestinal inflammation and lymphoid tissue formation. We further posit that a unifying principle underlying such functions would be the innate character of MCs, which we hypothesize are capable of directly sensing and metabolizing innate signals from microbiota or cytokines in order to exert homeostatic epithelial and immunological regulatory functions in the intestine.We will be using genetic approaches to target innate pathways in MCs and state of the art phenotyping to discover the physiologically important signals orchestrating intestinal homeostasis in various animal models of intestinal pathophysiology. We will also study MC lineage relations and plasticity during disease and develop ways to interfere therapeutically with MC physiology to achieve translational added value for intestinal diseases, as well as for a range of other pathologies sharing similar characteristics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Liquids Under Confinement In 2D-MATERials' (LUCiD-Mater).

assistant: **Concept**

Two-dimensional (2D) materials are a relatively new class of thin materials consisting of a single layer of covalently bonded atoms. The unprecedented characteristics of 2D materials have already led to the observation of new physics and lend themselves to a wide range of technology-focused applications. Both in the fabrication process and in applications, liquids frequently interact with 2D materials. In particular, droplets often become trapped between these thin materials and a rigid substrate, or between layers of vdW structures. However, the details of this trapping (or confinement), how the liquid becomes confined and its effect on the rest of the structure has been under-appreciated. We propose to develop mathematical models of this confinement in a number of scenarios motivated by recent experiments. The analysis of these models will give new insights into the optimization of various fabrication methods, as well as suggesting new methods through which the presence of trapped liquid droplets can be controlled and exploited. To meet the proposed objective, we will build on the fellow’s experience in the mechanics of 2D materials and their interfaces and the supervisor’s experience in the mechanics of slender structures and their interaction with liquids to propose integrated, multidisciplinary, multi-technique approaches.The fellow would be based in the Oxford Centre for Industrial and Applied Mathematics and would benefit from being integrated into both the intellectual and social life of the group. The fellowship will extensively broaden the fellow’s knowledge of the modelling of thin film/liquid systems and expand his network and collaborations through performing the project. Besides, the designed training activities of this fellowship will consolidate his skil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Epigenetic approach for the treatment of obesity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

It has been estimated a threefold increase in the number of obese people in Europe since the 1980’s. Currently, EUcountries spend an average of 7% of their public health budgets on diseases linked to obesity. The socio-economic impact ofobesity epidemic cannot be overrated. European societal needs require desperately a shift forward in the field of obesityresearch to be able to build new therapeutics strategies. Recent scientific evidences point toward a role of epigeneticchanges as major contributor in the obesity etiology. In the last decades, a huge amount of data clearly link epigeneticdysregulation to obesity onset. Yet, it remains unclear whether epigenetic dysregulation contributes meaningfully to obesityepidemic. Because weight gain only occurs when energy intake exceed energy expenditure, burning off excess fuelrepresent an attractive path to reduce obesity when diet and exercise are not enough. My preliminary data indicate thehistone methyltransferases Suv420h1 and Suv420h2 as pivotal players in metabolism regulation. By using knockout micespecifically in brown adipose tissue, this project aims at dissecting the role of Suv420h proteins in the etiology ofobesity. I will combine in vivo and in vitro analyses and genome wide studies to: 1) dissect the role of Suv420h proteinsin the epigenetic regulation of the pathways controlling weight balance in response to nutritional or environmental stimuli; 2) identify genes involved in the generation, maintenance or transmission of the epigenetic memory of exposure; 3) provide useful markers or therapeutic targets to treat obesity and metabolic diseases. My results have the potential to translate into therapeutics. This research will contribute to provide new clinical targets against obesity. The Experienced Researcher w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AEROcapture for Future spAce tranSporTation' (AEROFAST) targeting Seventh Framework.

assistant: **Abstract**

AEROFAST main goal is to invest and improve the AEROCAPTURE transportation mean. An important step to allow for human expansion into the solar system is to develop advanced transportation systems to move humans and cargo between GEO and LEO, and also returning them from the Moon or from Mars. Typically such vehicle must rely on aerocapture to be mass effective: using atmospheric drag to slow space vehicles is regarded as one of the largest contributors to making both lunar and Martian missions affordable. In the coming decade’s aerocapture will become one of the core capabilities for planetary transportation.  This technology allows for large amount of mass saved (up to 30 %) at launch and is fully adapted to large weight missions (Sample return missions and manned missions): for an insertion into a low Mars orbit with propulsion, 41% of the initial mass is put on final orbit whereas with an aerocapture manoeuvre 82% of the initial mass is put into final orbit.  Today the technology readiness level of such an aerocapture mission is roughly 2 to 3 in Europe. AEROFAST goal is to prepare for a flight demonstration on a planet with atmosphere (earth or even more attractive Mars) and to reach TRL 3 to 4 in the frame of this FP7 first call.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Developing Versatile and Robust Perception using Sonar Systems that Integrate Active Sensing, Morphology and Behaviour' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Versatile and robust systems able to respond sensibly to challenges not precisely specified in their design, as envisaged in Challenge 2 target outcome (a), depend on (amongst other competences) effective perception systems able to function in complex and variable conditions.  The principal objective of the proposed project is to discover how to engineer such systems, specifically embodied active sonar perception systems which can serve as a complement to vision and facilitate the deployment of robotic systems in situations where vision is infeasible.<br/>For understanding the implementation of sonar systems able to function in demanding and open-ended environments, the Chiroptera (bats) are an obvious source of ideas.  Their astounding diversity of diet and habitat attests to their success in integrating morphological, acoustic and behavioural parameters to enable robust and versatile hunting behaviours --- the bat equivalent of tangible object handling.<br/>The project will implement and evaluate two demonstration sensors built as biomimetic models of an insect gleaning and a water-trawling bat species respectively.  It will use a classic biomimetic methodology, involving close collaboration between bat ethologists and roboticists.  It will proceed by identifying and measuring the relevant acoustic and morphological parameters of a few carefully selected bat species, reconstructing from that the bat's acousticexperience as it flies through natural hunting tasks.  From this data, computational models of how the bat coordinates its acoustic, behavioural and morphological choices during hunting will be elicited and implemented on appropriate robotic systems.  The robustness, versatility and generality of these implemented models will be evaluated from an engineering stan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Building an AI-tool to facilitate the integration, accessibility, and usability of heterogeneous cultural heritage data on medieval manuscripts.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Data on our cultural heritage hold enormous potential for Europe’s economic growth, for the construction of a more inclusive narrative of its past, and for the future collective identity of its citizens. The biggest obstacle to unlocking that potential is the current lack of integration and interoperability among the countless datasets describing the holdings of European heritage institutions. ManuscriptAI will help remove that obstacle for the data on Europe’s medieval written heritage, manuscripts. Premodern handwritten books are a pivotal category of our heritage, yet they are currently underrepresented in large research infrastructures and their catalog data locked in digital silos. ManuscriptAI will employ machine learning algorithms to construct a model capable of facilitating the automatic integration of distinct data sources describing medieval manuscripts, under a predefined set of machine-understandable vocabulary terms. The model will be made accessible through a human engagement interface and tested during a pilot in a real-world setting. The project will fill two important desiderata: (1) a user-friendly AI-tool to allow heritage professionals to convert their metadata on manuscripts to Linked Open Data, and (2) a dedicated ontology for the description of medieval manuscripts to complete CIDOC-CRM extensions for the cultural heritage domain. The project, building on the achievements of the ERC-2018-stg PASSIM, is supported by a strong consortium of domain experts, heritage professionals and institutes, and (inter)national research infrastructures. ManuscriptAI will advance the EU’s agenda for digital heritage. The tool will help democratise datafication, making Linked Open Data accessible to small heritage institutions and actively involving them in its dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '“Valorization of European onion waste by-products into dietary fibre-based formula with hypocholesterolemic, hypoglycemic, and antioxidant effects”' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Being onions the second most important horticultural crop in the world (86 million tonnes, FAO 2014), production of onion waste has risen over recent years in Europe. Well over 500,000 tonnes of onion waste are generated in the European Union each year, mainly in Spain, The Netherlands, and the United Kingdom, becoming an economic (as high as €40/ton just considering disposal costs) and environmental problem (rapid growth of phytopathogens e.g. Sclerotium cepivorum (white rot) makes this waste also unsuitable to be used as fodder). At the same time, a third of ischaemic heart disease is attributable to high cholesterol, according to the World Health Organisation, and in high-income countries, over50% of adults have elevated total cholesterol. The Spanish SME Dietary Molecular Diagnostics, S.L. (BIOMEB), a spin-off of the University of Lérida, identified a commercial opportunity, offering sustainability on the use of onion-waste via their patented bioactive product FIBRACEP: a new dietary fibre-based formula obtained from onion agricultural by-products with scientifically validated reduction of cholesterol adsorption by 20% and proven increase of HDL-cholesterol levels by 50% (clinical trials already carried out), being a clear breakthrough (both in terms of health impact and costs) compared to best available commercial products. BIOMEB aims, thorough SMEInst-1 project, to produce a feasibility study and business plan, including the validation of customer demand, scaling-up of production of raw-fiber, introduction of FIBRACEP in meat and bread, and encapsulation for pharma-industry applications. We will also explore the need for a SMEInst-2 funding request. BIOMEB team counts with the confirmed collaboration on main players in the sector: CEBACAT, Indulleida, Laboratorio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Impact of changing land use practices and pollution on the vegetation dynamics of threatened European plant communities' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content Traditional areas with high pastoral value are being abandoned in Spain as a result of a decreasing rural population. Secondary successional processes are threatening heathland ecosystems, which were previously maintained in a biodiverse state through grazing management. Vegetation change is currently taking place in such sensitive communities all throughout Europe, but in different directions: abandonment of the traditional management in the Mediterranean countries and intensification in the Northern countries. Whereas several studies have being carried out to understand and prevent unwanted changes, no attempts have been made to examine how decreasing grazing pressure and increasing pollution interact to promote a change in the plant communities in Meridional latitudes and to compare this with the effects in Northern latitudes. This knowledge is essential in order to develop management plans to protect such important and diverse ecosystems at a European scale. Training content (objective, benefit and expected impact) The project will build on the work carried out in Scotland on vegetation dynamics of Calluna-dominated heathlands. It is intended to apply the gained ecological and technical knowledge the applicant's home less favoured region. The parallel nature of the two studies will allow to understand vegetation responses to grazing and increased nitrogen deposition on heathlands in different geographical areas. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cure Diabetes by Injection of Micro Pancreas Cell Therapy' under Horizon 2020.

assistant: **Concept**

Diabetes is a constantly growing concern in Europe and worldwide. Patients with Diabetes suffer from lack of insulin production. Without it, glucose remains in the blood and causes significant complications that can be both short term -seizures and fainting that could result in coma or even death, and long-term - stroke, heart disease, blindness, kidney failure and limb amputation. Betalin is developing a biologic cure to Diabetes: the Micro Pancreas that after implantation under the skin (by injection) restores natural insulin production and blood glucose regulation. Micro Pancreas is a revolutionary regenerative micro-organ, based on cell therapy comprising a proprietary organ derived 3D scaffold – Micro-Organ Matrix (MOM), isolated human pancreatic islets from donors and MSCs, which reduce the risk of immune response in patients and improve the islet viability and function. Micro Pancreas eliminates insulin dependency in diabetes patients, removing the need for daily injections and injections correlated with meals, constant blood glucose monitoring and dietary constraints.Instead, patients get a biological implant by injection of Micro Pancreas, that generates insulin naturally in response to glucose, improving considerably daily life of patients with diabetes, including children with Type 1 Diabetes and moreover, preventing the long-term complications caused by the disease.Following successful feasibility studies conducted thanks to the European Commission (EC) through SME Instrument Phase 1, a growing market was identified for Micro Pancreas, due to the increasing prevalence of diabetes worldwide. Total market value is expected to more than double from $6.6B in 2013, reaching a value of ~$13.6B by 2023 in drug and treatment sales, with a CAGR of 7.6%. Betalin's pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The use of fungal inocula in agricultural applications such as biodegradable mulch films and planting pots' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The development of biodegradable products originating from renewable resources has offered alternatives to synthetic products. However, products such as starch plastics are susceptible to biological attack making them not suitable for long-term applications. In the case of mulch film or plant pot the strength of the material is rapidly declining. The properties depend on the weather conditions. Recent advances in biotechnology have resulted in renewed attention for the use of fungi in agriculture. A number of fungi have been described as candidates for biological control agents. The proposed RTD work focuses on the development and commercialisation and the implementation of fungal inoculate in agricultural products, such as mulch films and planting pots. The incorporation of fungi during the production of these products will be studied to ensure the appropriate activity needed to obtain the right lifetime of these products during their use. The use of the envisaged products will lead to the reuse of agricultural resources and a reduction in waste and toxic chemicals. This will result in a significant decrease in production costs of the end-user such as tree nurseries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Friendly rest rooms for elderly people' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Problem addressed: Toilet facilities in public and private places do not fit the specific needs of many old people suffering from physical limitations. Objectives of the project: The major objective of this project is to do the research necessary and design, build and test prototypes for a Friendly Rest Room for older people with disabilities. All the elements of the toilet will adjust to the individual needs of elderly persons, allowing them to gain greater autonomy, independence therefore have a better quality of life.