RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Solving the Root Cause of Battery Short Circuits:FocalSpec high-speed 3D imaging sensors revolutionise industrial quality control' in the context of a Horizon 2020 call.

assistant: **Objectives**

With the market appetite for electric cars and consumer electronics increasing globally, battery manufacturers need to pack higher capacities into ever-smaller battery sizes. This sets extreme demands on manufacturing precision to ensure battery safety. Failing to do so caused for example the global Samsung smartphone recall in 2016 – microscopic imperfections in electrodes were too small to detect. Those imperfections led the batteries to short circuits, putting consumers in direct danger. While this might sound like a small issue concerning high-end smartphones – imagine if similar incidents happen in electric cars.FocalSpec revolutionary 3D imaging sensors offer laboratory level measurement accuracy for detecting microscopic imperfections on battery electrodes at the speed of manufacturing lines (moving 3 meters per second). Our technology enables carrying out submicron-level analysis of shapes, profiles, textures, thicknesses, dimensions, roughness, etc. No other industrial measurement solution, including laser, is able to combine such speed and precision. Other quality control systems cannot distinguish between 2D and 3D defects at so high speed, and are therefore not reliable in e.g. high capacity Li-ion battery manufacturing.Having validated the technical feasibility and major market demand for on-line version of our sensors, we will prepare our technology for wide scale adoption during this Phase 2 project. Our main objective is increasing the speed of our core 3D imaging sensors by over 100x and implementing it into a new, real-time measurement sensor that will significantly improve Li-ion battery safety in electric cars, which is a major up-and-coming growth area for the European industry. This opens up a total addressable market of over €1 billion already in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Tilt Rotor Integrated Air Intake and Engine Protection Systems'.

assistant: **Innovation**

TRIcEPS aims at fulfilling all the requirements of the JTI-CS2-2018-CfP08-FRC-01-21, “Development of integrated engine air intake and protection systems for Tilt Rotor” by designing, manufacturing, testing and qualifying the air intakes and their integrated engine protection system for the NextGenCTR technology demonstrator, contributing to meet the goals of the CS2JU FRC WP1. The proposed engine protection system is geared on two key enabling technologies:•a removable thermoelectric ice protection system based on the heater layer technology. This is already under development on the blade of the NextGenCTR and on the wing of the regional aircraft;•a vortex tubes filter for protecting the engine from ingestion of particles in harsh environment.The air intake will be equipped with a bypass for operation in clean flow and a compressor washing system. The choice of a vortex tubes instead of a barrier filter is key in TRIcEPS. This solution, despite providing 1-to-2% lower particle separation efficiency, allows for:•full self-cleaning capabilities, thus not requiring maintenance (i.e. fit and forget approach);•stable pressure drop in brownout operation, resulting in no need of emergency bypass actuation which would expose the engine to the harsh environment;•significantly reduced icing issues;•easier flight certification path, according to FAA;resulting in the best technical compromise for the NextGenCTR considering its mission profile. Moreover, this choice does not to infringe IPRs on tilt rotor air intake (as per patenting activities by Bell Helicopters on barrier filter), thus securing the position of Leonardo with respect to the future market.TRIcEPS will deliver the air intake, its engine protection system and all the relevant sub-systems at TRL 7, supplying Leonardo w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting epigenetic regulators during leukemia evolution' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

A major gap in knowledge exists relating to the mechanisms via which a normal hematopoietic stem cell attains a fully transformed state via preleukemic intermediates. It is now accepted that a key player in this transition is epigenetic plasticity. Identifying the epigenetic mechanisms regulating the transformation of normal to leukemic stem cells will open new avenues for the identification of therapeutics at different stages of disease. A characteristic stem cell-like gene expression pattern is a hallmark of aggressive acute myeloid leukemia. Intriguingly, most of these patients harbour mutations in epigenetic modifiers that directly regulate stemness. What is fundamentally missing is a comprehensive understanding of which chromatin factors are involved in maintaining normal stem cell programs and how they are modulated during leukemic transformation. I recently uncovered a novel epigenetic mechanism of transition to the leukemic-state, mediated by direct chromatin binding of mutant NPM1 and transcriptional regulation of a specific set of stem-cell genes. This discovery, together with cutting-edge ultra-low-input chromatin technologies and our recently developed in vivo models of preleukemia, will serve as the springboard to address these fundamental questions:1)  How are normal hematopoietic stem cell programs regulated at the epigenetic level?2)  What are the epigenetic landscape alterations that govern tumorigenicity? 3)  How can we exploit epigenetic dependencies to pharmacologically target the premalignant and/or malignant state?EpiTransformers will delve into the largely unexplored epigenome during the leukemic transformation of rare stem cell populations using cutting-edge epigenetic profiling technologies and sophisticated in vivo models to deconvolute differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Cryogenic 3D Nanoelectronics'.

assistant: **Innovation**

SEQUENCE will make use of unconventional approaches to develop cryogenic electronics with demonstration in applications spanning from quantum computing to satellite communication systems.Approach: SEQUENCE has aggregated a strong consortium consisting of 9 partners with well-documented experience in III-V and Si technology, including IC design skills. 3D integration of interfacing electronics with quantum computing technologies such as Si spin qubit layers, will be developed to reduce form factors, latency, and power consumption, enabling qubit multiplexing strategies to significantly reduce physical components count inside and outside the cryostat. We will develop RF functions such as LNAs, mixers, oscillators, DACs, multiplexers and RF switches, initiating a new generation of low-power cryogenic electronics, combining III-V and Si CMOS technologies, for scalable quantum computers. The development will be based on cryogenic transistor and circuits validated models, reducing IC design margins operated at extremely low power levels. Novel nanoelectronic devices will be developed, explored, and benchmarked providing performance added values, at cryogenic temperatures.Impact with our main outcomes:  A)  Cryogenic 3D integration technology and strategies with optimal balance between III-V, Si CMOS, and emerging device technologies – power/form factor constraints trade-off,  B) new set of critical cryogenic building blocks, C) A matured set of emerging nanoelectronics, up to TRL 4, with technology benchmark that bring added value and will support future transistor technology nodes, D)  An exploitation strategy of the technology developed targeting Quantum applications, space communication and sensing, and future wideband room temperature communication.  The SEQUENCE project,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'E-SCIENCE GRID FACILITY FOR EUROPE AND LATIN AMERICA'.

assistant: **Concept**

EELA-2 aims to build, on the current EELA e-Infrastructure, a high capacity, production-quality, scalable Grid Facility providing round-the-clock, worldwide access to distributed computing, storage and network resources for a wide spectrum of applications from European and Latin American scientific communities. <br/>The project will provide an empowered Grid Facility with versatile services fulfilling application requirements and ensure the long-term sustainability of the e-Infrastructure beyond the term of the project.<br/>The specific EELA-2 objectives  are:<br/>- Build a Grid Facility by:<br/>\tExpanding the current EELA e-Infrastructure to consist of more production sites mobilising more computing nodes and more storage space, at start of the project and to further grow storage over the duration of the project;<br/>\tProviding, in collaboration with related projects (e.g. EGEE), the full set of Grid Services needed by all types of scientific applications;<br/>\tSupporting applications various types (from classical off-line data processing up to control and data acquisition of scientific instruments), selected against well defined criteria (including grid added value, suitability for Grid deployment, outreach/potential impact);<br/>- Ensure the Grid Facility sustainability:<br/>\tThrough the already established and new contacts with policy/decision makers, collaborating with RedCLARA and NRENs and supporting the ongoing creation of e-Science Initiatives and/or National Grid initiatives (NGI).<br/>\tBuilding the support of the e-Infrastructure to provide a complete set of Global Services from a Central Operation Centre and to pave the way for the creation of Regional Operation Centres in Latin America:<br/>\tAttracting new applications;<br/>\tMaking available k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Groundwater effects on coastal ecosystems' in the context of a Horizon 2020 call.

assistant: **Objectives**

Coastal lagoons host some of the most dynamic, diverse and productive ecosystems on Earth, which are subject to significant pressure from human activities. Hydrological land-ocean connectivity is a universally accepted important driver of coastal ecosystems, but the ecological effects of groundwater and associated solute fluxes to coastal systems remain poorly understood for most of the world’s shores. The overall goal of GRECO is to evaluate the role that groundwater fluxes play in the functioning and vulnerability of coastal lagoon ecosystems, by studying its effects on primary producers. This project encompasses a suite of innovative and interdisciplinary investigations aimed at (a) documenting the spatio-temporal distribution of groundwater-derived freshwater and nutrient inputs to lagoons and the exposure of benthic communities to groundwater-borne nutrients; and (b) evaluating the groundwater-derived effects on lagoon primary productivity by identifying the nutrient sources for primary production and the role of groundwater in lagoon ecological functioning. To these aims, two economically and ecologically important French lagoons with contrasting hydroecological conditions will be investigated by using new methods for coastal groundwater studies: 3D hydrodynamic numerical modeling and nutrient stable isotope analysis in primary producers. The novel understanding of groundwater-ecological interactions derived from this project will significantly advance the state-of-the art of groundwater studies in the coastal zone by providing direct evidences of ecological effects of groundwater discharge and by adding new methods to study groundwater implications. The results of GRECO will allow closing a current gap in the fundamental understanding of coastal processes, improv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Barents  Sea Arctic Cenozoic Evolution and Paleogeographical Reconstructions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project ""Barents Sea Arctic Cenozoic Evolution and Paleogeographical Reconstructions (BRAVO)"" aims to reconstruct the Barents Sea Gateway since the Cenozoic (the last 66 Myr). To do so, BRAVO’s objectives are to 1) reveal the effect of sediment loading–unloading, lithospheric strength, and surface-mantle processes on shaping the Cenozoic paleobathymetry-topography of Barents Sea, to 2) constrain the timing of the formation of the BSG, to 3) identify the interplay between climate dynamics and tectonics in erosion and deposition of sediments in the paleo-Barents Sea, and (4) compare the development of the BSG and Fram Strait, as well as the regional to global consequences of the Arctic-Atlantic shallow water connection. BRAVO will achieve these objectives by numerical modelling (inc. finite element and volumetric methods) using open-source platforms of pyGPlates, pyBadlands and high-resolution 2D–3D seismic, well, gravity and magnetic data analyses. BRAVO’s results will be self-consistent 4D Earth models (space and time) of paleobathymetry-topography of Barents Sea Gateway and corresponding sedimentary pathways and accumulation. BRAVO’s ambition is to provide the most reliable paleobathymetric-topographic reconstruction of the Barents Sea Gateway for the Cenozoic. BRAVO will quantify the role of Barents Sea Gateway in exchanging Atlantic–Arctic water, highlight the significance of erosion–deposition of sediments in shaping the gateway, and form the basis for updated global oceanographic and climatic simulations. BRAVO’s pioneering model of the complete Cenozoic source-to-sink analysis for the regional Barents Sea will be a breakthrough for Arctic seabed characterization for offshore wind turbines and mapping slope failure geohazards.""


**Keywords:** Arctic, Seism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genomic binding sites for prp (prion) proteins. chip based screening test for cjd (creutzfeldt-jacob) disease.' (1998-2002).

assistant: **Innovation**

Expression profiles of normal and infected tissues with Transmissible Spongiform Encephalopaty using DNA microarray technology. Genomic binding sites for Prep proteins. Development of chip" based diagnostic test for CJD using specific photoaptamers."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Light and recyclable car (LIRECAR)' (LIRECAR) targeting Fifth Framework.

assistant: **Abstract**

Automotive industry is committed to the Voluntary agreement on CO2 emissions reduction and will be subjected to the EU Directive on End of Life Vehicles. Use of lightweight materials is one of the promising solutions to meet the CO2 emission reduction target. Lightweight design options will also have met the recycling targets. These issues have to be investigated using a holistic approach in order to avoid omission or shifting of potential environmental impacts from a product life cycle phase to another. LIRECAR aims at assessing the environmental impacts of lightweight materials all through their life cycle. Study will be based on Life Cycle Assessment methodology following the ISO 1404X standards. Results will consist of an analysis of the strong and weak points of lightweight design scenarios and guidelines for better integration of environmental aspects in car design phase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'INcreasing safety in NPPs by Covering gaps in Environmental Fatigue Assessment - focusing on gaps between laboratory data and component SCALE' (INCEFA-SCALE) targeting Horizon 2020.

assistant: **Abstract**

The objective is to continue work, advancing ability to predict lifetimes of Nuclear Plant components when subjected to Environmental Assisted Fatigue loading.  Over the five years proposed for INCEFA-SCALE, EPRI in the USA is leading a series of component scale environmental fatigue tests.  These are expected to advance data availability significantly; however, advances in addressing transferability of laboratory scale tests to real component geometries and loadings will still be constrained by limited test data.  This knowledge gap is recognised worldwide as significant.INCEFA-SCALE will generate significantly increased understanding of the transferability of laboratory scale test data to component scale.  The project strategy will be (1) the development of comprehensive mechanistic understanding developed through detailed examination of test specimens and MatDB data mining, and (2) testing focussed on particular aspects of component scale cyclic loading.  Examples of tests possible include, uniaxial specimens with notches (to address complex loads), membrane tests (to address biaxiality), thermo-mechanical tests (to address thermal cycling and thermal gradient effects), and complex wave tests (to address real plant transient effects).  The project will begin by “data mining” to extract maximum understanding from the vast amount of test data within JRC’s MatDB database (from the predecessor INCEFA-PLUS project, and from other external sources such as USNRC, EPRI, MHI and the AdFaM project).  In parallel the test program needs will be agreed.  Testing will commence after one year and run for 3 years.  Finally, the project will deliver guidance on use of laboratory scale data for component scales.Industrial support, is demonstrated by over €3M matching funds and positiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Oxygen sensing in macrophages: implications for cancer and ischemia' in the context of a Seventh Framework call.

assistant: **Objectives**

Macrophages exist in distinct differentiation states. Proangiogenic/immunosuppressive (M2-like) macrophages and antitumoral/proinflammatory (M1-like) macrophages represent two extremities of a continuum. Because lineage-defined subsets have not been identified yet, macrophage heterogeneity is likely to reflect the plasticity of these cells in response to microenvironmental signals. The concept that hypoxia can induce inflammation has gained general acceptance. However, little is known on how extravasated monocytes and their macrophage progeny react to a condition of low oxygen. Different macrophage phenotypes have been positively and negatively associated with the clinical outcome of vascular disorders as cancer and ischemia. These pathological conditions are characterized not only by dysfunctional vessels, which impair oxygenation, but also by strong immunoregulatory responses. Recently we have shown that reduced activity of the oxygen sensor PHD2 in macrophages skews their polarization towards a proarteriogenic (M2-like) phenotype, which confers protection against ischemia. Based on these findings, we propose to dissect upstream and downstream signals to the oxygen sensing machinery and hypoxia-response in macrophages. By using a genome-wide transcriptional profiling approach and a high-throughput interactome analysis, combined with mouse genetic tools, we will identify the gene signature of macrophages in hypoxia and unravel the molecular executors of this response. The identification of the effectors responsible for macrophage skewing in relation to oxygen availability will contribute to a better understanding of immunoregulatory cues during disease progression and unveil the multifaceted function of macrophages during vessel formation. With the focus of our researc