RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Pancreas Regulome: From causality to prediction of non-coding mutations in human pancreatic diseases'.

assistant: **Innovation**

Several human pancreatic diseases have been characterized, being the diabetes the most common. Like others, this genetic disease is related to disrupted non-coding cis-regulatory elements (CREs) that culminate in altered gene expression. Although Genome Wide Association Studies support this hypothesis, it’s still unclear how mutations on CREs contribute to disease. The translation from the “non-coding code” to phenotype is an exciting and unexplored field that we will approach in this project with the help of the zebrafish as a suitable animal model. We aim to uncover the implications of the disruption of pancreas CREs and how they contribute to diabetes in vivo. For this we will study transcriptional regulation of genes in zebrafish. The similarities between zebrafish and mammal pancreas and the evolutionary conservation of pancreas transcription factors (TF) make it an excellent model to approach and study this disease. In this project we will characterize the zebrafish insulin producing beta-cell regulome, by determining the active CREs in this cell type and their bound TFs. Then we will compare this information with a similar dataset recently available for human beta-cells, to define functional orthologs in these species. Selected CREs will be tested by in vivo gene reporter assays in zebrafish, focusing on those functionally equivalent to human CREs where risk alleles have been associated with diabetes or those regulating genes involved in diabetes. Later these CREs will be mutated in the zebrafish genome to validate their contribution to diabetes. Finally we will translate this to predict new human disease-associated CREs by focusing on the regulatory landscape of diabetes-associated genes, without the need of having countless patients to uncover them. With this p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Rapid pulse width modulated CO2 ejector for small-scale vapour-compression systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Small-scale Refrigeration, Cooling&Heating (RC&H) sector plays a vital role in modern life promoting health, comfort and economic prosperity. On the other hand, it is also responsible for a considerable contribution to global warming. The urgent need for an eco-friendlier future has forced the European Union (EU) to implement stringent energy and environmental policies, affecting this sector significantly. These have led such a large and ever-growing industry to suffer for the lack of a long-term solution complying with safety and EU’s requirements.This project aims at filling the aforementioned technological gap by studying an innovative and future-proof small-scale vapour-compression RC&H unit relying on: (1) CO2, being a non-flammable, non-toxic and climate-friendly refrigerant, as the sole working fluid and (2) a two-phase ejector with a novel capacity control technique. The core of the work is to establish the experimental evidence and expertise regarding the innovative capacity control methodology for CO2 two-phase ejectors. At present, two-phase ejectors cannot readily be capacity controlled without penalizing ejector and system efficiency in small-scale RC&H units. As concrete value and impact, this project will lay robust foundations for a significantly more sustainable future and thus pave the way for remarkable enhancements for business and society concerning the RC&H sector.The fellow is a proficient researcher with a strong background in large-scale CO2 refrigeration systems using two-phase ejectors. The results and the experience that the applicant has obtained make him the ideal candidate for successfully achieving the project objectives. This work is a unique opportunity for the fellow to become an independent scientist, enhancing and developing new skil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Support and Coordination of the Partnering Environment for FET Flagships'.

assistant: **Objectives**

The SCOPE strategic objective is to promote a partnering environment with the Flagships by providing flexible and efficient mechanisms to perform activities that will be in line with the overall Flagship objectives and be of mutual benefit to all parties. In particular, the consortium will address the need for support of Partnering Projects in order to engage in collaborations with the Core Projects by identifying strategic opportunities and providing support for networking and dissemination between the Core and Partnering Projects. The enhancement and support in developing partnerships that will serve the Flagships objectives and raise awareness about the accomplishment of Flagship goals in terms of scientific leadership, economical and societal benefits.These specific actions will be carried out throughout the project lifetime with the main objective to progressively bring coherence into the Flagships “ecosystems”. The expected measureable impacts will be in term of the level of integration and participation in research, governance, networking and dissemination activities of the Partnering Projects in both of the Flagships.The SCOPE Consortium brings together different perspectives and expertise in order to achieve the goals of the project and contribute going a step forward in supporting the partnership environment in FET Flagships. They will ensure policy-level communication, coordination between and among them, networking, and other relevant actions around HBP or Graphene Core Projects and the stakeholders of the scientific community.


**Keywords:** Graphene,  Human Brain,  FET Flagships,  Partnering Projects,  Partnering Environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Moldovan Research for YOUth' to be submitted under Seventh Framework.

assistant: **Abstract**

The MORE4U is a project conceived to increase the awareness of research as a solution to the numerous challenges faced by people all around the world and mainly in Europe. The goal of the present project is to reveal to the non-academic public the role of researchers in transforming ideas into ready-made useful products available to all citizens. In doing so the activities foreseen are going to involve an audience as young as pre-school age kids, teenagers to young adults and adults from a great variety of fields didactic staff, doctors, entrepreneurs, clerks, etc. among them. An important target group of the project will be students.The MORE4U project will promote public recognition of researchers and their profession and bring them closer to society. The project also aims to stimulate young people to embark on scientific careers and to enhance the attractiveness of Europe as host territory for researchers.The successful accomplishment of project objectives will be ensured by the professional experienced team comprising researchers, national contact points and project managers selected to carry on a number of activities involving the majority of the significant Moldovan research institutions from all country regions.  The big event with a festive character to be organized on September 27, 2013 will bring scientists to the spotlight offering them a tribune from which to initiate a dialogue with a public able to offer an immediate feed-back through the questionnaires elaborated for this particular event.The expected results are summarized as follows:•Contribution in structuring a public recognition of researchers in Moldova society.•Promotion of better understanding among the general public that researchers are a between them.•Attraction of young people in sciences and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'How does population structure influence host-pathogen dynamics in mosquito-transmitted diseases?'.

assistant: **Objectives**

Computational advancements and the development of powerful agent-based simulation frameworks have allowed us to model unprecedented realism in mosquito-transmitted diseases – a threat that millions of people face every year. While this enhanced realism has already provided important insights, agent-based models are still often outperformed in disease forecasting by their idealized mathematical counterparts. This might be caused by a lack in our fundamental understanding of how spatial dynamics need to be appropriately modeled. To date, in depth sensitivity analyses of complex agent-based models that would help to address this issue are hardly conducted, because these complex models are very parameter rich. Thus, the required model recalibration and comparisons are very runtime intensive. I introduce Gaussian processes as a powerful statistical framework that will significantly advance sensitivity analysis for agent-based models and allow us to assess the relative input importance of different model parameters in unprecedented detail. The proposed research could further deepen our understanding of how spatial structure affects host-pathogen dynamics and be a valuable contribution to the field of sensitivity analysis for agent-based models. I expect to find that spatial structure changes disease transmission potential profoundly and can cause spatial-specific model dynamics. I hope that my findings contribute to the improvement of disease forecasting and evaluation of proposed intervention strategies.


**Keywords:** Spatial population structure, Sensitivity analysis with Gaussian processes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Support for the activities of the European Group on Ethics (EGE) by European Academia and Ethics Bodies' to be submitted under Horizon Europe.

assistant: **Abstract**

SAEGE is a Horizon Europe project that enhances the integration of ethical insight into EU policymaking in response to rapid developments in science and technology. The overall goal of SAEGE is to support the European Group on Ethics in Science and New Technologies (EGE) in its mission to advise the European Commission (EC) on all aspects of EU policy and legislation where ethical, societal, and fundamental rights dimensions intersect with the development of science and new technologies. As innovations increasingly affect social norms, human rights, and the environment, SAEGE helps ensure that ethics remains central to science governance in the EU. SAEGE provides structured, ethics-based evidence and analysis to inform the EGE’s advice. This includes literature reviews, expert consultations, stakeholder workshops, and full evidence review reports that translate diverse inputs into policy-relevant ethical assessments.The project aligns with the EGE’s 2021 call for ethics rooted in “comprehensive and pluralistic thinking,” informed by sound science, critical analysis, and inclusive societal debate. To support this vision, SAEGE is developing the EGE Et Alia Advisory Network (EGEAN), which connects the EGE with actors in the ethics and science advise landscape. The EGEAN will support SAEGE’s work through stakeholder mapping, an online hub, and ethics policy briefings. To anticipate future issues, SAEGE will also implement a horizon scanning and early alert system using tools such as social media trend analysis, web scraping, and text mapping. These insights will be distilled into Horizon Scanning Briefs to inform proactive, ethically grounded EU policymaking.


**Keywords:** ethics advice, research ethics, EU policymaking, EGE, science governance, human rights, ethical ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The role of the serotonin 5-HT4 receptor in motor and non-motor symptoms of Parkinson’s disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Parkinson’s Disease (PD) is caused by dopaminergic neuron loss resulting in motor symptoms that are treated with L-DOPA.However, ≤90% of patients develop involuntary movements, termed L-DOPA induced dyskinesia (LID). Another less well studied, buthighly occurring PD symptom is depression.There is evidence that the serotonin system is implicated in both, LID and PD-linked depression. Serotonergic (5-HT) neuronsuncontrollably release L-DOPA-derived dopamine, and HTR1a/b agonists counteract such release and LIDs. Serotonin re-uptakeinhibitors (SSRIs) also attenuate LID, through a still unknown mechanism. The striatally enriched Gαs-coupled receptor, HTR4, has thepotential to enhance excitability of spiny projection neurons, to affect the balance of striatal pathways that is disrupted in PD and is acandidate to modulate LID and PD-depression.D2 agonists reduce depressive behavior in PD models, pointing towards a role for the striatum. Specifically, the dorsolateral striatumshows diminished metabolism, in contrast to non-PD-depression where the ventral striatum is a substrate. HTR4 in cortex andhippocampus was linked to antidepressant action. Agonists and overexpression yield anti-depressant-like responses, however,striatal HTR4 in PD-depression has not been examined.1. We will determine HTR4 protein expression on a cellular level (dSPNs, iSPNs) in transgenic mice. We will virally overexpress,knockdown and pharmacologically manipulate HTR4 and assess striatally-driven behaviors.2. We will probe HTR4 in motor symptoms by altering expression/activity in unilaterally 6-OHDA lesioned mice. We will evaluate LIDonset/severity, dyskinesia markers and LTP, depotentiation and LTD.3. We will test bilaterally-lesioned mice with altered HTR4 expression/activity in depression/anxiety par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GaAs Nano-OptoMechanical Systems' in the context of a Seventh Framework call.

assistant: **Objectives**

A Nano-OptoMechanical System (NOMS) is an ideal interface between nanomechanical motion and photons. The merits of such a system depend crucially on the level of optical/mechanical coupling. For sufficient coupling, the nanomechanical motion is efficiently imprinted on photons and read-out with the assets of optical detection: broadband, fast, ultra sensitive (ultimately quantum limited). Moreover, in a NOMS, the very dynamics of the motion (its frequency, damping, noise spectrum) can be controlled by optical forces. This opens novel roads for nanomechanical sensing experiments, both classical or quantum, that need now to be experimentally investigated and brought in compliance with future on-chip applications.This project relies on Gallium-Arsenide (GaAs) disk optomechanical resonators, where photons are stored in high quality factor optical whispering gallery cavities and interact with high frequency (GHz) nanomechanical modes. We have recently shown that these resonators possess a record level of optomechanical coupling and are compatible with on-chip optical integration. The first aim of the project is to investigate in depth the mechanisms leading to optical and mechanical dissipation in GaAs nanoresonators, and obtain GaAs NOMS with ultra-low dissipation. The second aim is to realize prototype nano-optomechanical force measurements with a GaAs disk resonator set in optomechanical self-oscillation, to establish the potential of this novel approach for sensing. This will be done both under vacuum and in a liquid. The behavior of two NOMS integrated on the same chip will also be studied, as first archetype of parallel architectures. A third aim is to operate GaAs NOMS at their quantum limit, using cryogenics, optomechanical cooling and novel concepts where an active
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Summarisation and Sentiment Analysis for Evolving Multilingual Media Content' to be submitted under Seventh Framework.

assistant: **Abstract**

News aggregators gather thousands of news articles every day from across the world and cluster them into news stories comprising large numbers of articles about the same event. This is even augmented by the increasing amount of information in social media (e.g., Twitter, Facebook) where mass opinions about news events can be monitored. A promising way to reduce this bulk of highly redundant data is offered by the language technologies known as multi-document text summarisation and sentiment analysis. A major problem is that news articles are in many languages while current technology has mostly dealt with English, and the question of how current research can be applied in a heavily multilingual context has barely been addressed.Most multi-document summarisation research has focused on the news domain and MediaGist will do likewise in order to build on existing techniques and resources. However, summarising posts in social media, representing complementary and unbiased information, will be considered as well. Media professionals, however, will want to go beyond summaries from sources in one language and consider how news events are reported in other countries and from other perspectives. Identifying differences in opinion towards entities and events may provide some clues as the disagreements in reporting across languages. MediaGist will perform multilingual sentiment analysis and will thus make possible the generation of summaries that reveal these disagreements.The goal of MediaGist is to make significant advances in multilingual research so as to extract and present the GIST (the main content and opinions) of online multilingual news and the corresponding content in social media.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Social Collective Intelligence' under Seventh Framework.

assistant: **Concept**

The Social-IST Support Action aims at catalysing interdisciplinary collaborations and at organising consultations of multidisciplinary research communities on the theme of Social Collective Intelligence. The term is used to denote a class of socio-technical systems that combine, in a coordinated way, the strenghts of humans and groups in terms of competences, knowledge and problem solving capabilities with the communication, computing and storage capabilities of advanced information and communication technologies. Social Collective Intelligence systems have the potential to radically change the way we approach and tackle global societal challenges.The Social-IST project will deliver a White Paper on research challenges in Social Collective Intelligence and a Roadmap document for possible future FET initiatives in the field. The proposed Support Action will leverage on a multidisciplinary Scientific Panel with leading scientists in the respective fields, that will be brought together in two highly interactive workshops. Online consultations will be run to gather inputs from the scientific community at large.The results of the Support Action will be presented in a final public event, that will target high-profile representatives from academia and industry, together with European Commission delegates.