RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Remote strategies for fossil finding: multispectral images and species distributional modelling applications for large-scale palaeontological surveys.' (REFIND).

assistant: **Concept**

The REFIND project aims to create a standardized methodology for large-scale palaeontological surveys. The protocol will be applied to the recovery of single exposed fossils, by comparing high-resolution multispectral images with the response of fossils to laboratory-light wavelengths. Where fossils cannot be directly detectable, my method applies the use of GIS spatial analyses to the palaeogeographical distribution of species, filtered with biotic and abiotic data, to recognize suitable areas for new fossil localities.Images will be acquired by multispectral sensors placed on satellites and drones, and predictions will be computed using softwares for spatial raster analyses. Results will consist of thematic maps predicting the location of new exposed fossils and sites, and coordinates will be partially verified through field expeditions.The proposed software tools are available to the large public only since recent years, and their application is now crucially important for preventing the destruction of undiscovered palaeontological heritage by humans and climate changes. The REFIND project will allow researchers to minimize costs and risks related to field research, and to access the first Fossil Endmember Library and to the largest database for Late Pleistocene fossil evidence.The implementation of my results will change the approach of European researchers to palaeontological field work and add to the importance of the European historical fossil collections.I have previous experience in both fields developed in the REFIND project, being developed in the project, allowing me to achieve of all the proposed results. The acquisition of new skills during the fellowship will significantly upgrade my career potential, because multispectral and raster analyses, cutting-edg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Clean acid technology using ionic liquids' in the context of a Fourth Framework call.

assistant: **Objectives**

A key target for the European Chemical industry in order to enhance its competitiveness is to manufacture high value products more efficiently and with significantly reduced environmental impact. In particular, replacing commercial add catalysts (mineral acids, Lewis acids) and organic solvents with non volatile, recyclable alternatives would enhance product quality and significantly reduce effluents in most major sectors e.g. specialities, petrochemicals, solvents, pharmaceuticals and intermediates. The project aims to introduce, in the EU, technology based on novel, non volatile, recyclable liquids known as 'ionic liquids', as alternatives to acid catalysts and organic solvents currently used widely in all chemical sectors. A definition of an ionic liquid is a non volatile, low melting point molten salt, typically of mixed organic inorganic character (e.g. dialkylimidazolium chloride aluminium chloride) The partners in the consortium have already shown ionic liquids to be very effective acid catalysts and highly efficient solvents. The involatile ionic liquids do not produce vapour emissions, thus reducing levels of VOC's. The impact of ionic liquid catalysts and solvents will be to reduce catalyst/solvent waste inventory and to offer cleaner, low temperature chemical processing routes than are currently possible. The most advanced industrial applications of ionic liquids to date are at bench scale in the catalyst sector. For example, in tests for benzene alkylation with olefins (C5 8), ionic liquid catalyst was more active than sulfuric acid (46 % versus 25 % benzene conversion), gave higher selectivity to desired monoalkylated product (95 % versus 78 % molar selectivity) and was almost completely recyclable (99.5 % recyclable). Similarly, ionic liquid catalysed the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Promoting excellence and recognition seal of European aerospace Universities' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The proposed action is expected to contribute to better meeting the needs of the aerospace sector for highly skilled workforce and to enhance the mobility of aerospace students and professionals across Europe.Taking into consideration the complex skills needed by the aerospace sector, the action will develop the required learning outcomes and competence profiles for aero-engineering curricula and propose the aerospace specific accreditation criteria that would complement the existing European, national or regional accreditation systems for engineering education.The action will be developed in three distinct phases. The first phase is a conception phase. The learning outcomes and procedures will be defined looking at current practices and involving the main stakeholders of the higher education chain, from Universities to Industries and Research Establishments. The result should be a staged accreditation system, thereby gradually enhancing the quality level of the higher education degrees. The second phase is an implementation phase. The identified processes are tested on 6 aerospace curricula, from different EU countries. The third phase is a refinement phase. The results of the testing phase are compared to the expectations and the processes are updated taking into consideration the lessons learned from the testing phase. Suggestions for harmonizing the curricula and simultaneously developing knowledge and emerging technologies as well as facilitating students’ exchanges across the EU will be proposed. In parallel to the three phases, a dissemination and outreach activity is implemented to diffuse the culture of best practices among the EU higher education courses in the area of aerospace engineering and attract talented students to such studies.The consortium members i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Superconducting Diamond Quantum Nano-Electro-Mechanical Systems' (SUPERNEMS) targeting Horizon 2020.

assistant: **Abstract**

In this project, the fabrication and characterisation of all diamond superconducting Nano-Electro-Mechanical Systems (NEMS) is proposed for the investigation of macroscopic quantum states. This involves state of the art Chemical Vapour Deposition (CVD) of diamond, doping, nanofabrication and modelling of devices. The fundamental properties of superconducting diamond, the associated mechanical properties of diamond NEMS and the characterisation of low temperature and low dimensional quantum effects will be investigated. Critically, the unprecedented resonant frequencies of diamond cantilevers allow the possibility of cooling cantilever devices down to the ground state. Coupled with its superconducting-based read out possibilities, this material offers new opportunities for challenging the Standard Quantum Limit, the study of quantum entanglement and the fabrication of superconducting diamond Qubits. This work is highly ambitious, as it aims to manipulate systems by exploiting fundamental quantum limits. However, the applicant has already demonstrated the individual constituents of this approach and thus it is not reckless to propose to integrate them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structural and functional studies of eukaryotic and prokaryotic topoisomerases and their complexes with molecules of therapeutical interest' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Type II DNA topoisomerases (topoII) control DNA topology during replication, transcription and chromosome segregation. Essential for cell proliferation, topoII are targets of antibacterial and antineoplasic compounds of prime importance for human health. The emergence of antibiotic resistant bacterial strains and the selection of resistance clones during cancer treatment urge for the development of new drugs and for a better understanding of their mode of action. This proposal aims at the functional and structural study of eukaryotic and prokaryotic DNA topoisomerases to provide knowledge on their mechanisms and on drug interference. Structural research in the field is to date limited to individual domains which do not recapitulate the enzymatic functions. Solving the atomic structure of a full length topoII is key to understand their mechanism and the molecular basis for inhibition by drugs binding at domain interfaces. Our primary goal is to conduct structural studies on a full length bacterial topoII, DNA gyrase, in complex with molecules of therapeutic interest such as the leading quinolone antibiotic family. The success of our project is bound to our ability to stabilize a defined conformation of the enzyme. The human topoII shares high sequence conservation and a similar structural organization with the bacterial enzyme. It is a biomarker for cancer and a key chemotherapy target for anti-tumour drugs such as the etoposides. Results obtained on DNA gyrase will provide valuable information to study the structure of human topoII, its drug binding mechanisms, and the effect of mutations found in resistant tumors. Finally, we plan to investigate the role of topoII in a more integrated context and in particular its interactions with the transcriptional apparatus. A co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advancing Collaboration and Exchange of Knowledge Between the EU and Japan for AI-Driven Innovation in Manufacturing' (2014-2020).

assistant: **Concept**

Artificial Intelligence technology is already having a great impact in many areas, especially including the manufacturing sector. The integration of AI with advanced manufacturing technologies and systems makes it possible to exploit the full potential in the manufacturing industry by achieving a higher level of adaptability, efficiency and robustness. At the same, such systems will be human centric and promote the inclusion and cooperation with humans during planning and execution which can help to improve the quality of products and processes. Both the EU and Japan have recognised these new development trends and their importance. In order to widely deploy these technologies, special attention is given to international cooperation and exchange of knowledge between EU and Japan for AI-driven innovation in manufacturing. The EU-Japan.AI project is responding to this need by implementing a platform-based approach to connect all the relevant stakeholders from EU and Japan working on AI applications for manufacturing. This platform, beside other tools, will include an open-information hub, encouraging the exchange of information on the respective research programmes and technological results. This will be supported by distribution of topic relevant materials, information on upcoming events and matchmaking opportunities and twinning activities to establish a vibrant and connected network at the heart of the platform, where a community of practice approach will facilitate the cooperation of all the participants. Convergence workshops will help to establish how research and innovation projects should address AI for manufacturing, the needs and requirements for AI from the point of manufacturers’ view as well as to address current needs and future requirements. Overall, the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Optimal design of observational networks'.

assistant: **Innovation**

ODON is a pilot project in optimal ocean observing system design. ODON will1 ) investigate/develop techniques in optimal observing system design,2) design ad hoc and rational sampling strategies for SST and temperature/salinity (T/S)profile monitoring in the Baltic & North Sea by using statistical analysis (including synergy among satellite, buoy, floating profiler, ferry and XBTsections),3) demonstrate improvements in ocean now casts/forecasts due to improvements in the observing networks by using Observing System Simulation Experiment (OSSE), and4) perform cost-benefit analysis of the designed observing networks. ODON meets challenges, explores new fields and improves capacity building in quantitative ocean observing system studies in Europe, and justifies implementation of new observing systems in coastal/shelf seas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Communities and Connectivities: Iron Age Britons and their Continental Neighbours' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Recent breakthroughs in ancient DNA and isotope analysis are transforming our understanding of diversity, mobility and social dynamics in the human past. COMMIOS integrates these cutting-edge methods on a scale not previously attempted, within a ground-breaking interdisciplinary framework, to provide a radically new vision of Iron Age communities in Britain (800 BC – AD 100) within their wider European context. At the broad scale, we will conduct the first concerted programme of genome-wide ancient DNA analysis on Iron Age populations anywhere in the world (c. 1000 individuals in the UK, 250 in Europe), mapping genetic clusters to shed light on ancient populations themselves and on their relationships to modern genetic patterning. Together with isotope analysis, and underpinned by both osteoarchaeological and cultural archaeological approaches, this will also enable us to directly address critical issues of population movement and inter-regional connectivity in Iron Age Europe. We will utilise the power of these new scientific methods to examine the structure and social dynamics of Iron Age societies in Britain, including household and kin-group composition, the identification of familial relationships, gender-specific mobility, and the development of social inequalities. Previously the preserve of cultural anthropologists studying recent societies, we will draw these questions into the archaeological domain, opening up new areas of enquiry for prehistoric societies. The scope and scale of the project represents a new departure for European archaeology, made possible by the coming-of-age of new analytical methods. Many of these have been pioneered by the project team, which comprises world-leaders in the fields of ancient DNA, isotope analysis, osteoarchaeology, chronol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Deciphering the role of chromatin in epidermal stem cell biology'.

assistant: **Objectives**

The skin is a multi-layered epithelium consisting of interfollicular epidermis (IFE), hair follicles (HF), sebaceous glands (SG) and apocrine (sweat) glands. Continuous shedding of terminally differentiated keratinocytes necessitates constant regeneration to ensure tissue homeostasis. This depends on the epidermal stem cell compartment located on top of the basement membrane. Several of the signaling pathways involved in this process are known (e.g. Myc, Wnt, Rac1, Notch, and EGFR) and under investigation. Commonly, the end-point of signaling pathways is regulation of transcription. In the cell, transcription takes place in a chromatin context and requires modification of the histones. However, the role of these modifications in epidermal stem cell maintenance and differentiation remains poorly understood. The proposed work aims to provide novel insights into the function of chromatin in these processes. Human epidermal stem cells are easily obtained and retain their ability to terminally differentiate in vitro upon certain stimuli, as determined by involucrin expression. Making use of sh/siRNA mediated knock-down, factors involved in regulation of chromatin will be tested for their role in epidermal stem cell differentiation. Interestingly, recent work of the Watt laboratory showed that Myc-induced differentiation involves histone acetylation. A second of research will be aimed at identifying the gene-expression programs underlying lineage commitment. Recent advances have been made in the Watt laboratory to differentiate human sebocytes into either IFE or SG. This system will be subjected to gene expression profiling to uncover the determinants of commitment to either lineage. In addition, RNAi based screens for chromatin factors involved in this process will be initia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development and Application of finite element and meshfree methods for fluid-structure interaction' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The objective of our project is to develop novel numerical tools for fluid structure interaction (FSI) and to apply these methods to problems in Aerospace and Aeronautical Engineering. The methods can be later on incorporated into commercial software. T he new methods and concepts will handle FSI in a more efficient and accurate manner and are interdisciplinary applicable. We use concepts such as IFEM, level sets and adaptivity. They are explained in detail in part B of the proposal. IFEM is a novel, efficient method for FSI problems. It will be coupled with level sets. Level sets are well suited to describe interfaces of geometrically complicated structures. They can also be exploited for modelling fracture and for pre- and post processing. Adaptive approaches will be used to refine along the fluid-structure interface in order to reduce computational cost and numerical errors. The project will be divided into three parts: modelling the FSI, modelling the fluid and modelling the structure. The first and largest part involves also efficient coding techniques such as parallelization, domain decomposition and multi-scale approaches in time. These techniques will improve the overall efficiency of the software. The second part will address details such as locking and stabilization. In the last part, our methods will be applied to a variety of problems in aerospace and aeronautical engineering. Here constitutive modelling of the structure is also a major concern. Hereby, we are interested in the response of large structural components such as wings. We will develop structural (shells) elements which can handle fracture in an efficient and accurate manner. Therefore, we can resort to concepts in the first part of the project, i.e. level sets and adaptivity. This facilitates th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A novel concept for support to diagnosis and remote management of tremor' (NeuroTREMOR).

assistant: **Innovation**

Tremor is the most common movement disorder and is strongly increasing in incidence and prevalence with ageing. The most frequent types of tremor are those arising from two neurodegenerative disorders: Parkinson's disease and essential tremor. Although not life threatening, upper limb tremors hamper independent life of 65% of those suffering from them, greatly impacting on their quality of life. Tremor is not effectively managed in 25 % of patients and is one of the most commonly misdiagnosed neurologic disorders.The main objective of the project is to validate technically, functionally and clinically, a novel system for understanding, giving support to diagnosis, and remotely managing tremors. The system will comprise two platforms:- The hospital-based platform will provide with detailed recordings of the central and peripheral nervous systems together with kinematic measurements. It will constitute the most advanced system to date for neurophysiological investigation of tremors, and will implement a novel machine tool to support diagnosis of tremors.- The neuroprosthetic platform will constitute a novel alternative for remote management of upper limb tremors. It will exploit neural and kinematic recordings both to drive a closed loop system to attenuate tremors based on neurostimulation of the afferent pathways, and to evaluate the status and evolution of the disorder. The platform will thus permit the neurologist remotely monitoring and adjusting the therapy.NeuroTREMOR consortium brings together world-class institutions in their respective fields. Some of the partners collaborated previously in the framework of EU and NIH projects aiming at understanding and managing tremor pathologies, accumulating considerable experience on proposing and validating novel therapies