RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The best drug discovery platform'.

assistant: **Concept**

Mcule.com aims to provide the best web-based drug discovery platform for pharmaceutical researchers (big companies, contract research organisations and academics). We aim to create an easily searchable chemical database of 500 million purchasable compounds, the Ultimate database. The Ultimate database would be primarily based on virtual (not yet synthesized, but predicted to be synthesizable) compounds. Such a large chemical space would present a major advantage for pharma and biotech companies by increasing their chances to effectively identify novel compounds, reducing their costs and time losses. This development will increase our market share and promote our growth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wavelets and multiscale methods in numerical analysis and simulation', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the last few year, new ideas related to multiscale decompositions and In the framework of the project we will put down a program of post-doctoral training, consisting in opening several post-doc positions in highly wavelet bases have appeared, fueled by a strong input of theoretical analysis and approximation theory. Several remarkable features of such qualified research centers (for a total of about 260 Man/Months). A program concepts seem to suggest that, if fully developed, the corresponding of doctoral studies consisting in intensive courses and summer schools methodology should be capable in the long run of advancing the frontiers. We feel that young researchers would greatly benefit from a training by leading experts in this higly interdisciplinary field, which will in numerical simulation. The aim of this project is first to provide a addition help in broadening their horizons. In fact the expertise that they theoretical foundation addressing several crucial issues (which will be better specified in the proposal description). Secondly the project aims at will acquire applicable to fields as diverse as image processing, analysis of stochastic processes, denoising, fractals and multifractals, developing a class of innovative fast numerical schemes for the numerical solution of integral and partial differential equations. These new schemes which, though not directly included in the research project proposed, take advantage of the same tools and are of growing importance in the will combine on one hand high order approximation, and on the other adaptivity with respect to data, operators and solutions. They will be development of Numerical Analysis flexible enough to be adapted to a variety of complex problems in such areas as fluid dynamics, electromagnetism and e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'In vivo studies and screens for new factors that promote or suppress tumor metastasis'.

assistant: **Objectives**

Metastasis is the process whereby a primary tumor (usually highly malignant in nature) spreads to distant locations in the body. Understanding step-by-step how particular confined tumors acquire invasiveness and/or spreading potential is a scientific challenge that can help us to develop new strategies for metastatic cancer prevention or treatment. In mouse models and in humans, the inactivation of the E-cadherin gene and the activation of genes of the SNAIL family are markers of the initiation of metastasis from epithelial tumors – a process that is called epithelial-mesenchimal transition, and that is similar, albeit not identical, to what occurs during normal development. In vivo, however, neither the activation of E-cadherin nor the activation of SNAIL genes is sufficient to trigger malignant transformation, indicating that additional unknown factors are required for this process to take place. Our project has as its main objective to develop and explore genetically traceable animal models that recapitulate the initial steps in malignant transformation of tumorous growth in vivo. With these animal models we intend to understand the molecular mechanisms that activate (or inactivate) genes that trigger metastasis and that convert a stationary eptithelial cell into an invasive one (ie, one with the capacity to invade and degrade the basal lamina). We hope that these models will help to open new fields of investigation to isolate new potential targets for therapeutic intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Investigations into Martian Volatiles'.

assistant: **Objectives**

The aim of this research is to determine how the volatile element content of the martian interior, surface and atmosphere changed over geological time. This aim will be achieved via cutting-edge sub-microscopic mineralogical analyses (via transmission electron microscopy (TEM)), as well as ambitious measurements of the hydrogen isotope content and abundance of water, chlorine and fluorine in hydrous phases within martian meteorites of differing ages (via secondary ion mass spectrometry (SIMS)).  The results of this research will allow us to address important unanswered questions about the formation and evolution of Mars, such as:• How wet is Mars’ interior compared to the Earths, and how has this changed over time?• Is the martian mantle well mixed like Earths, or heterogeneous like that of the Earth’s moon?• Was there ever significant volatile cycling at the martian surface?Answering these questions will help determine how similar the Earth and Mars really are, hence this research has strong astrobiological implications.Through collaborations with researchers at the University of Hawaii and the Carnegie Institute (Washington D.C.) we will have access to a large suite of different martian meteorites, hence we will be able to produce an unprecedented amount of systematic data.The proposed mineralogical and chemical data will be cutting edge, as only a few laboratories worldwide have the instrumentation and expertise to perform these measurements. Dr. Hallis’ intimate knowledge of martian meteorite mineralogy and chemistry, extensive experience with SIMS hydrogen isotope measurement protocol and sample preparation, and advantageous collaborations make her uniquely positioned to carry out this research. Outstanding TEM capabilities, as well as the presence of a supportive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Injection, transport and manipulation of spin currents in new organic materials' to be submitted under Seventh Framework.

assistant: **Abstract**

This project will study spin injection, transport and manipulation in a variety of materials, from simple metals to organic semiconductors (OSC).Spintronics is an area of electronics that aims to exploit the spin of the electron. Although it is one of the selected areas to play a role in the post-CMOS electronics, spintronics still must prove its full potential in many subjects. One particularly important is the long distance spin transport and spin manipulation. For spintronic devices to be successful, i) they should transport spin for distances in excess of 100 nm and ii) they must have a lateral structure for multiterminal integration. Spin transport with these conditions have been achieved in metals and conventional semiconductors, although there is a need for materials with better spin transport properties and spin manipulation has still to be developed in any material.OSC, which are being integrated in mainstream electronics such as LEDs and FETs, may play an important role in the developing of organic spintronics. OSC have a very small spin-orbit coupling, which make them ideal as spin transporters. Combining conventional spintronics with OSC will allow us to open a new perspective in this field. The combination of magnetic and organic materials will allow us to understand the spin transport in carbon-based materials, to determine the potential of OSC in spintronics and to manipulate spins in non-conventional environments.The project will start by growing and characterizing the organic materials we will study on top of ferromagnetic materials and tunnel barriers and vice versa. This will allow us to obtain optimized organic vertical spin valves and study their transport properties. In parallel,  we will fabricate spin valves with lateral geometry using metals, pu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bioinspired, biphasic and bipolar flow batteries with boosters for sustainable large-scale energy storage' to be submitted under Horizon 2020.

assistant: **Abstract**

To satisfy our growing energy demand while reducing reliance on fossil fuels, a switch to renewable energy sources is vital. The intermittent nature of the latter means innovations in energy storage technology is a key grand challenge. Cost and sustainability issues currently limit the widespread use of electrochemical energy storage technologies, such as lithium ion and redox flow batteries. As the scale for energy storage is simply enormous, the only option is to look for abundant materials. However, compounds that fulfil the extensive requirements entailed at low cost has yet to be reported. While it is possible that the holy grail of energy storage will be found, for example by advanced computational tools and machine learning to design “perfect” abundant molecules, a more flexible, innovative solution to sustainable and cost-effective large-scale energy storage is required. Bi3BoostFlowBat will develop game changing strategies to widen the choice of compounds utilizable for batteries to simultaneously satisfy the requirements for low cost, optimal redox potentials, high solubility and stability in all conditions. The aim of this project is to develop cost-efficient batteries by using solid boosters and by eliminating cross over. Two approaches will be pursued for cross-over elimination 1) bio-inspired polymer batteries, where cross-over of solubilized polymers is prevented by size-exclusion membranes and 2) biphasic emulsion flow batteries, where redox species are transferred to oil phase droplets upon charge. Third research direction focuses on systems to maintain a pH gradient, to allow operation of differential pH systems to improve the cell voltages. Limits of different approaches will be explored by taking an electrochemical engineering approach to model the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigations into the role of bacteria/dinoflagellate interactions in paralytic shellfish poisoning' (1994-1998).

assistant: **Innovation**

The project has the following objectives:a) To determine the role of bacteria in dinoflagellate toxicity by defining the bacterial flora with molecular markers and by elucidating their influence on dinoflagellate toxicity with reference to laboratory cultures and the environment.b) To define the physical association of bacteria with dinoflagellates throughout the latter's life cycle.c) To determine the influence of bacteria on shellfish toxicity, and the prevalence of such bacteria in sea water and shellfish.Molecular probes of high specificity to the microflora of selected dinoflagellate species will be produced, in order to supplement the use of traditional microbial culture techniques in monitoring the progress of various treatments in removing dinoflagellate-associated bacteria. Depending on the success of the latter either axenic dinoflagellate cultures or those which have a limited defined bacterial population will be used to determine the influence of bacteria on toxin production of dinoflagellates. The techniques developed will also be utilised to determine the influence of natural bacterial populations on dinoflagellate toxicity. The work will be supplemented with TEM, confocal microscopy and flow cytometry, to determine the physical association of bacteria at different stages of the dinoflagellates life cycle. The influence of bacteria on shellfish toxicity either through direct toxification or the ability to metabolise the PST toxins will also be evaluated. The frequency of occurrence of these bacteria in the environment and potential relevance to toxic events will also be determined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Developing a virtual and molecular control board for diverting cancer stem cell to non-malignance' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Over the past few years, evidence has accumulated supporting the hypothesis that cancer robustness may be attributed to a small portion of the tumour mass, the cancer stem cells (CSCs). This leads us to propose a more target-oriented treatment for cancer. Our approach is geared towards the addition of Master Switch factors in the microenvironment of the CSCs that will lead to their differentiation into non-proliferative and non-malignant cells. These master switch factors are normally present in the normal stem cell niche to regulate homeostasis. Our proposal is subdivided in in vitro studies, in silico modelling and in vivo testing (transplantation in animal models) of stem cells representing two types of solid tumours: brain and breast cancers. To achiev e our goal, the master switch factors will be identified and delivered locally, in and around the tumour. For that purpose, we will use microbeads loaded with the Master Switch protein(s) to deliver, only locally, a high concentration of the differentiatin g factor(s), recreating a normal microenvironment. Since it relies on the addition of proteins in the environment of the cancer stem cells, we will use a lab-on-chip system to cultivate and study a small number of CSCs in a controlled microenvironment. Fin ally, it is known that not all tumours even of a same type respond in the same way or at the same speed to an identical treatment. We therefore propose to develop biomathematical models of the behaviour of the CSCs based on parameters identified first in v itro and later in vivo. This biomodelisation will help generating the control board, a realistic predictive model aiming at the custom-tailoring of the tumour treatment. We will then be able to propose a conceptually novel treatment that will include an a pproac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanism-Based Integrated Systems for the Prediction of Drug-Induced Liver Injury' (MIP-DILI) targeting Seventh Framework.

assistant: **Abstract**

The current test systems employed by Industry are poorly predictive for Drug induced liver injury (DILI). The ‘MIP-DILI’ project will address this situation by the development of innovative preclinical test systems which are both mechanism-based and of physiological, pharmacological and pathological relevance to DILI in humans. An iterative, tiered approach with respect to test compounds, test systems, bioanalysis and systems analysis will be adopted to evaluate existing models and develop new models that can provide validated test systems with respect to the prediction of specific forms of DILI and further elucidation of mechanisms. The approach will encompass completely characterised cell lines, well-defined and physiologically stable hepatocytes, multi-cell type in vitro models including novel bioreactors, animal models and appropriate ex vivo human cell models. A systematic analysis of data and iteration at each stage will select the ‘best’ cell line, animal model or pathway for further investigation moving from simple systems to more complex models with reference to relevant clinical and preclinical data on the various forms of DILI. Triangulation of human, in vitro and animal data will provide a fundamental understanding of how drugs can harm the liver.  It will then be possible to define the application of each particular novel test system in the context of drug development, and its use in the prediction of liabilities associated with the various forms of DILI that occur in man. Just as importantly, the project will define those models that are not appropriate as decision-making tools for the prediction of DILI in man.The MIP-DILI consortium contains Key Opinion Leaders from academia, the biotechnology sector and the pharmaceutical industry in the fields of drug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Carnivorous zooplankton - their role in the arctic pelagic ecosystem'.

assistant: **Innovation**

The aim of the present proposal is to contribute to a better knowledge about carnivorous zooplankton, their trophic role in artic pelagic ecosystem, with emphasis on their predation on the key species Calanus spp. in West Greenland waters. The West Greenla nd society is entirely dependent on marine resources for economical as well as subsistence utilisation. In the Arctic, greenhouse warming over the next century is predicted to be 2-4 times higher than at lower latitudes. Increased human impact on marine ecosystems combined with effects of global climate change stresses the need for a sustainable ecosystem-based management.  Today, knowledge of the trophodynamics of marine food webs in the artic is relatively fragmentary. Consequently, the knowledge base for a proper ecosystem management is inadequate.  The large dominating copepods Calanus finmarchicus, C. glacialis and C. hyperboreus are the main food source for numerous species of fish, birds and whales. The understanding of their mortality is therefore cruc ial. Carnivorous zooplankton have been found to have a substantial impact on prey communities and selective predation by zooplankton may influence the trophic structure of the pelagic ecosystem.  The diets of carnivorous zooplankton will therefore be investigated during the Arctic spring and summer. Simultaneously, prey composition and vertical distribution will be determined and used to estimate predation pressure. The proposed training does not only provide new knowledge about Greenlandic food webs, it is also a long-term investment in the fellows future research career.  The specific training will give her the expertise, self-confidence and maturity to carry out high level research as well as give her valuable experience in networking, fund-raising and projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New concepts for upgrading pulp mill waste streams to value-added chemicals' (WACHEUP), addressing dissemination and exploitation.

assistant: **Impact**

The objective is to upgrade low-value residual products from kraft pulp and cork manufacture into valorised green chemicals, with methods that can be efficiently integrated with the pulp/cork mills. Considerable residual streams become low-value heat at th e mills with no practical use. This is a sub-utilisation of the potential of the chemicals in the residuals. Their broad spectrum of organic compounds could be processed to value-added chemical products, utilising the energy surplus of the wood/cork mills for the manufacture. Expected innovations: - New technologies for valorisation of pulp and cork mill waste without impairing overall energy economy or quality of the primary products. - New value-added products from current low-value energy streams - Va lorisation of polysaccharides in the black liquor through a new method that preserves the structure of the material for valorisation into paper additives, thickeners, food additives, emulsifiers and adsorbents. - Chemical and biotechnical valorisation of bark/cork suberin (a natural polyester) and extractives hitherto undeveloped natural resources into green polymers, composites and specialty chemicals. The whole value-chain is covered: Advanced methods for fractionation and purification of the raw mate rials, biotechnical and chemical valorisation and application potential. The sustainability of the industries is improved through better utilisation of the wood material, and decreased fossil fuel dependency and emissions of CO2 may become possible.