RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fisheries Data Capture and Management System' (FiDaCaMS) under Horizon 2020.

assistant: **Objectives**

The aim of the FiDaCaMS project is to build a new innovative system that enables fishermen to collect accurate and reliable fisheries and related environmental data in an automated and highly efficient form.One of the major issues across the marine environment is that increasingly stringent management controls are being implemented requiring clear & hard evidence to support management decisions. In the absence of such evidence the precautionary approach is adopted, creating restrictions for commercial fishing activities amongst others. At the same time the available resources to gather the evidence centrally is being cut, thus widening the gap between the need and availability of evidence. To aid the fishing industry meet the pressing needs they must be equipped with appropriate tools that collect the evidence in a robust and automated form. The successful implementation of FiDaCaMS will provide the technology necessary for the collection and aggregation of the required data and rendering it available through an online platform in multiple formats across diverse media thus facilitating the adoption of the regulations set by the EU and the local governments. During an event held in Brussels on 5th April 2016 - Info Day for Blue Growth, it was expressed that this sector lacks innovation for Blue Economy specifically in 3 areas (a) lack of highly skilled professionals (b) under investment in Knowledge and technology and (c) a slow process from research results to the commercial stage. The FiDaCaMS project aims to contribute towards overcoming all 3 obstacles. (a) Employ and train professionals, (b) invest in R&D to continue to innovate and create new technologies and to (c) accelerate market presence and penetration.The FiDaCaMS project is a joint venture between 3 commerc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Magnetic resonance imaging techniques to improve drug development and patient management in acute stroke (MIDAS)' (MIDAS) under Fifth Framework.

assistant: **Objectives**

The alleviation of the severe personal and socioeconomic consequences of acute stroke awaits tools to better understand the underlying mechanisms of the disease, to more rapidly identify efficacious drugs, and finally to support treating physicians at sites with limited diagnostic capability.The proposed project will perfect state-of-the-art functional magnetic resonance imaging (MRI) techniques into markers with high sensitivity to disease progression in acute stroke. Based on a large database of patient cases and sophisticated predictive algorithms, a prototype diagnostic toll will be built, allowing support in acute stroke patient management by predicting final outcome in individual patients, thereby identifying patients amenable for therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Evolutionary epistemology applied to universal symbiogenesis and universal punctuated equilibrium'.

assistant: **Innovation**

Evolutionary theory currently extends the biological realm because it is applied to the humanities, leading to new disciplines such as evolutionary archaeology, evolutionary linguistics and evolutionary psychology. These disciplines are characterized by a universal selectionist approach, i.e. mostly the theory of natural selection is applied to study phenomena such as cognition, language and the rise of symbolism. Although natural selection is the hallmark of the Modern Synthesis, a multitude of evolutionary theories are currently under study, the most important ones are symbiogenesis and punctuated equilibrium. It is interesting, from within an evolutionary epistemological approach, to also investigate how the theories of symbiogenesis and punctuated equilibrium can be universalized and applied to deal with linguistic, cognitive and cultural phenomena. Therefore, from an evolutionary epistemological stance, it will be investigated how one can abstract logical skeletons of symbiogenesis and punctuated equilibrium, that can then be applied to language and culture (besides life).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Overcoming stellar activity in radial velocity planet searches' in the context of a Horizon 2020 call.

assistant: **Objectives**

Radial velocity (RV) planet searches are a key exoplanet detection method, and one of the only ways to measure a planet's mass. The best RV instruments today reach precisions well below 1 m/s, something which would have seemed impossible 30 years ago. The key factor limiting the sensitivity of RV surveys now is stellar activity. Regions of enhanced magnetic flux on the stellar surface alter the shape of absorption lines in the stellar spectrum, and perturb the measured RVs. I have developed physically motivated but flexible, data-driven methods to disentangle planets from activity in RV data, which are critical to the success of future surveys. I now propose to apply these state-of-the-art techniques to the very large sample of multi-epoch spectra collected by HARPS and HARPS-N, the leading RV spectrographs of the past decade, and then to the forthcoming Terra Hunting Experiment (THE), which will use a copy of HARPS on a dedicated telescope to search for Earth-analogues around nearby stars. The combined HARPS(N) archives are a treasure trove of information on activity-induced perturbations to spectra and RVs, which is currently under-exploited. This project have a transformative effect on our understanding of different types of activity effects, their dependence on stellar properties, and their signatures in the spectra and RVs. It will reveal planets that were missed by previous analyses, particularly around active (young) stars. Finally, it sets out a clear route to the efficient mitigation of activity effects that the THE survey requires to achieve its goals. THE will discover some of the best exoplanet characterisation targets for the next 15-20 years, and my ERC-funded team will be central to its success.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Glucose metabolism and mTOR pathway role in CD8+ T cell control of HIV-1'.

assistant: **Objectives**

Antiretroviral therapy can decrease HIV-1 below the limit of detection but fails to eliminate the virus completely. One of the main goals of a HIV-1 vaccine is the generation of cytotoxic CD8 T cell responses that counteract the virus. CD8 T cells participate in the control of viremia early but progressively show weakened functions, which leads to loss of virus control. HIV controllers are a rare group of infected patients who can control the virus for years without antiretroviral therapy. CD8 T cells from HIV-controllers display an outstanding capacity to eliminate infected CD4 T cells ex vivo but the underlying mechanisms are still not understood.Preliminary data aiming at establishing a single cell transcriptional signature associated with control of HIV suggest an important role of the mTOR pathway during the chronic stage. This pathway plays a major role in glucose metabolism and CD8 T cells cytotoxic function. This raises the hypothesis that the extraordinary HIV-suppressive capacity of HIV-controllers CD8 T cells is associated with the modulation of mTOR pathway and glucose metabolism.This project aims to 1) Study the single cell gene expression of HIV-specific CD8 T cells in HIV patients longitudinally from acute to chronic stages and understand the factors linked to control and loss of function of CD8 T cells during disease progression. 2) To characterize the role of mTOR pathway in the ability of CD8 T cells from HIV-controller to eliminate infected cells and test if this pathway can be modulated to fine-tune anti-HIV CD8 T cells responses. 3) To understand if an optimal glucose metabolism is necessary for CD8 T-cells suppression of HIV and if this capacity can be improved by increasing available glucose. This work will help to understand the characteristics o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum confinement effects in semiconductor microlaser structures' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

SUBJECT Our intention is to study theoretically the microscopic properties of semiconductor microlaser structures. The research will be done in the theory division of the semiconductor group, lead by Professor Stephan W. Koch (Fachbreich Physik, Philipps University, Marburg, Germany). MOTIVATION The microlasers offer improved performance compared to the conventional semiconductor laser. They offer many potential innovations for the telecommunication industry. However, the theoretical behaviour of the microlasers is still unknown. The combined knowledge of the applicant and the host institution provide an excellent starting point for the theoretical investigations. WORK PROGRAMME The project is planned to last for two years due to its demanding nature. We plan to proceed in three stages: we study microlasers 1) with bulk semiconductor as active material (first six months) 2) with quantum well heterostructures in active material (next six months) 3) and their quantum properties according to models developed (last one year).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Lomustine with or without reirradiation for first progression of glioblastoma: a pragmatic randomized phase III study' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Recurrent glioblastoma is an invariably fatal refractory cancer with dismal prognosis. Patients suffer from low quality of life and very burdensome symptoms. This project is proposing an investigator-initiated phase III randomised pragmatic clinical trial. We will assess whether the addition of radiation treatment to lomustine chemotherapy has superior efficacy as compared to lomustine chemotherapy alone for treatment of patients with recurrent glioblastoma. The study will apply minimal patient eligibility criteria, and thus be as close as possible to the routine clinical setting. Cost-effectiveness analysis will be performed to investigate the economic value of adding radiation treatment to lomustine chemotherapy in different countries to support evidence-informed policy decisions. If successful, the outcomes of the project will define a new evidence-based standard of care for recurrent glioblastoma. The proposed research could lead to improved patient survival and quality of life but also improving health system sustainability. This is a multidisciplinary and multistakeholder consortium involving clinical oncologists, radiation oncologists, health economists and patient representatives. The study design was successfully discussed with patients. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment.”


**Keywords:** Glioblastoma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Study of the role of apolipoprotein E (apoE), a key component of the lipid and lipoprotein transport system, in the development of obesity-related osteoarthritis'.

assistant: **Concept**

Osteoarthritis (OA) is the most common disease of the joints. However, the molecular mechanisms that are involved in its pathogenesis are still unclear. One of the major causes of OA is obesity. The past few years a lot of studies have focused on the functional link between adipose tissue and cartilage in the development of OA. It has been recently shown that apolipoprotein E (apoE) over-expression promotes diet-induced obesity in mice. In addition, in vitro studies have demonstrated that apoE gene deficiency enhances the reduction of bone in mice fed high-fat diet, while lack of ApoE leads to increased bone formation in mice fed chaw diet. Triggered by these findings, in the present proposal the applicant will use in vivo, biochemical and molecular methodologies in order to investigate the role of ApoE in the pathobiology of obesity-induced OA in mice and explore its implication in the development and progression of OA in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The macroevolutionary impact of epigenetics and lateral gene transfer on eukaryotic genomes'.

assistant: **Innovation**

Multicellular organisms (e.g., animals, fungi and plants) are the best-studied eukaryotes but their ancestors and the vast majority of eukaryotic diversity correspond to microbial species (“protists”). The evolutionary history of protists is closely connected to the evolution of the eukaryotic cell itself.However, most protist diversity is still genomically unexplored, limiting our investigation of eukaryotic evolution. For example, while the importance of lateral gene transfer (LGT) in prokaryotic evolution is well recognized, its role in eukaryotic evolution is still debated. In addition, although epigenetic mechanisms represent a hallmark of eukaryotic genome regulation, we know surprisingly little about the evolution of these mechanisms across eukaryotic diversity.The overarching goal of my project is to understand how epigenetic mechanisms and LGT have shaped the macroevolution of eukaryotic genomes. This project has several inter-related intermediate objectives, which each in themselves will bring crucial insights into eukaryotic evolution: 1) reconstructing a robust phylogeny of eukaryotes; 2) inferring the gene content of the Last Eukaryotic Common Ancestor; 3) tracing the evolution of genes involved in epigenetic mechanisms and obtaining epigenomic maps from under-studied protists; 4) investigating the intriguing hypothesis of a possible interplay between epigenetic regulation and horizontal gene transfer and its influence on eukaryotic genome evolution: Have genes involved in epigenomic mechanisms been transferred between eukaryotes? Do epigenomic modifications affect the frequency of LGT in different lineages?To achieve this, I will characterize the transcriptomes, genomes, methylomes and small RNAs of understudied eukaryotic microbes selected for their key p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Communication in Action:  Towards a model of Contextualized Action and Language Processing' to be submitted under Horizon 2020.

assistant: **Abstract**

Language is fundamental to human sociality. While the last century has given us many fundamental insights into how we use and understand it, core issues that we face when doing so within its natural environment—face-to-face conversation—remain untackled. When we speak we also send signals with our head, eyes, face, hands, torso, etc. How do we orchestrate and integrate all this information into meaningful messages? CoAct will lead to a new model with in situ language processing at its core, the Contextualized Action and Language (CoALa) processing model. The defining characteristic of in situ language is its multimodal nature. Moreover, the essence of language use is social action; that is, we use language to do things—we question, offer, decline etc. These social actions are embedded in conversational structure where one speaking turn follows another at a remarkable speed, with millisecond gaps between them. Conversation thus confronts us with a significant psycholinguistic challenge. While one could expect that the many co-speech bodily signals exacerbate this challenge, CoAct proposes that they actually play a key role in dealing with it. It tests this in three subprojects that combine methods from a variety of disciplines but focus on the social actions performed by questions and responses as a uniting theme: (1) ProdAct uses conversational corpora to investigate the multimodal architecture of social actions with the assumption that they differ in their ‘visual signatures’, (2) CompAct tests whether these bodily signatures contribute to social action comprehension, and if they do so early and rapidly, (3) IntAct investigates whether bodily signals play a facilitating role also when faced with the complex task of comprehending while planning a next social action. Thu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The steenrod algebra and connections with modular representation theory, particularly generic representation theory'.

assistant: **Concept**

Research objectives and content  The aim of this research project is to study the structure of the Steenrod algebra and its connections with representation theory. The structure of the Steenrod algebra is revealed to a large extent by its action on the cohomology of an elementary abelian p-group and it is by studying this action that. on one level. our goal is to be achieved. This cohomology ring has a natural action of the general linear group which interacts with that of the Steenrod algebra thus providing one example of the connections between the Steenrod algebra and representation theory that this project is concerned with. On another level, there is an equivalence between a category of generic' representations satisfying some finiteness condi- tions, and a quotient of the category of 'unstable' modules over the Steenrod algebra. This is a rather different example of the connections we are concerned with. which we aim to study in further detail. Training content (objective, benefit and expected impact)  The theory of unstable modules and the connection with 'generic' representations was largely developed by Lannes and Schwartz in Paris and Henn in Heidelberg. Therefore I anticipate that by spending time in Paris I will learn much on this subject from the first two authors as well as from likely visits by the third.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Multi-Parameter Live-Cell Observation of Biomolecular Processes with Single-Photon Detector Array'.

assistant: **Concept**

Fluorescence single-molecule (SM) detection techniques have the potential to provide insights into the complex functions, structures and interactions of individual, specifically labelled biomolecules. However, current SM techniques work properly only when the biomolecule is observed in controlled environments, e.g., immobilized on a glass surface. Observation of biomolecular processes in living (multi)cellular environments – which is fundamental for sound biological conclusion – always comes with a price, such as invasiveness, limitations in the accessible information and constraints in the spatial and temporal scales.The overall objective of the BrightEyes project is to break the above limitations by creating a novel SM approach compatible with the state-of-the-art biomolecule-labelling protocols, able to track a biomolecule deep inside (multi)cellular environments – with temporal resolution in the microsecond scale, and with hundreds of micrometres tracking range – and simultaneously observe its structural changes, its nano- and micro-environments.Specifically, by exploring a novel single-photon detectors array, the BrightEyes project will implement an optical system, able to continuously (i) track in real-time the biomolecule of interest from which to decode its dynamics and interactions; (ii) measure the nano-environment fluorescence spectroscopy properties, such as lifetime, photon-pair correlation and intensity, from which to extract the biochemical properties of the nano-environment, the structural properties of the biomolecule – via SM-FRET and anti-bunching – and the interactions of the biomolecule with other biomolecular species – via STED-FCS; (iii) visualize the sub-cellular structures within the micro-environment with sub-diffraction spatial resolution – vi