RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploiting the hsp70 chaperone machine for novel therapeutic strategies in human diseases and for the engineering of productive cellular biomolecular factories' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Hsp70 is the central component of a multi-chaperone machine involved in many essential cellular processes and in the response of cells to proteotoxic stresses (e.g. heat shock). Furthermore, Hsp70 is a potent anti-apoptotic protein that can enhance transformation and the tumorigenic potential of cells. This proposal aims to obtain detailed knowledge of the function of the Hsp70 machine and its regulation by co-chaperones. This knowledge will be used to gain insight in its exact role in disease pathogenesis with special emphasis on cancer. The results are expected to reveal new possibilities for therapeutic interventions. The knowledge obtained will, furthermore, be exploited to improve the industrial use of mammalian cells as protein factories by attacking major problems in the large- scale production of therapeutic proteins in mammalian cells, i.e. increased apoptosis, sensitivity to temperature shifts, and incomplete protein folding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dielectric heating to improve the deep-fry process' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

During the production of deep-fry snacks (fish sticks, meat rolls, nuts etc.) the products are heated in oil which was heated using gas. To meet a high throughput the oil-temperature is kept high which degenerates the oil rapidly creating carcinogenic substances. This again contaminates the snack products. A commercially exploited filter system developed by the prime proposer already cleans up most of the oil so it can be reused for heating. This proposal envisages the research and development of a novel dielectric heating technique which heats both the products and the oil at the same time and which in combination with the existing filter system improves the deep fry process in such a way that a higher snack throughput will be achieved with less energy consumption, in a smaller cabinet so it can be installed in cafeterias and the like and with an extended life-time of the oil used. Taste, flavour, appearance and transportability of the snacks will remain the same. Specific objectives are: - a reduction of the oil temperature with 40 degrees Celsius - Iife-time extension of the oil with a factor 5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'effIcieNt Small scale uniT for distributed heAt and hydrogeN generaTion'.

assistant: **Objectives**

The project task is the development and validation of an efficient catalytic fuel processor as the key component of smallscale units for combined heat and power (CHP) generation in residential applications, based on hydrogen-fuel cells and fed bynatural gas, air and water. A critical issue of these devices is the intensification of the heat supply in the compact methane steam reformerwhere hydrogen is generated. To this purpose we exploit the findings from my ERC AdG project INTENT, developing areformer design based on thermally conductive cellular structures packed with catalyst microparticles. As demonstratedalready in INTENT by lab scale tests, the flow independent conductive heat exchange mechanism enables a highly effective powersupply to the endothermic catalytic reaction even in the case of low and fluctuating flow rates, as typical of these compactunits.The INSTANT project aims at testing this novel configuration of the fuel processor at a semi-industrial scale (TRL5). Indicators which will be evaluated during the test sessions include: 1) the H2 productivity for a given catalyst load (target = +30%); 2) the start-up time to full load (target = -30%); 3) the response time to a load change (target = -30%). Based on the experimental outcomes, INSTANT will also assess the potential for reducing the footprint of the CHP unit, the system volume being currently one of the main constraints for domestic CHP applications, as well as the overall production cost, including life-cycle costs. If successful, INSTANT will pave the way to a new generation of CHP systems based on hydrogen fuel cells, to be used in residential applications and, in perspective, in hydrogen refueling stations for fuel-cell vehicles, thus contributing to the decarbonisation of the EU energy system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role Of Biodiversity In climate change mitigatioN' in the context of a Seventh Framework call.

assistant: **Objectives**

To realise the full potential of tropical forests in climate change mitigation (CCM) & the provision of other ecosystem services in the face of ongoing global change we must improve our understanding of the relationships between biodiversity (BD) and the socio-ecological processes through which we respond & adapt to change.ROBIN will provide information for policy & resource use options under scenarios of socio-economic & climate change to: quantify interactions between terrestrial BD, land use & CCM potential in tropical Latin America; develop scenarios for CCM options by evaluating their effectiveness, unintended effects on other ecosystem services (e.g. disease mitigation) and their socio-ecological consequences. We will achieve this by combining new techniques (including remote sensing) for BD assessments in complex multi-functional landscapes, data-based analyses, integrated modelling & participatory-driven approaches at local & regional scales. Case studies along a gradient of sites in Mesoamerica and Amazonia will be used to develop understanding of the relationships between BD & CCM options & feed policy development. These studies will improve understanding of the options favourable to stakeholders & barriers & drivers affecting adoption of resource management strategies.Key deliverables will be: improved understanding of the role of BD in climate change; participatory-driven strategies & tools for CCM; assessments of the risks & uncertainties associated with CCM options. The main impact of the work will be improved outcomes from CCM & BD protection measures by providing natural resource managers in Latin America with guidance on how BD & ecosystems can be used in CCM without creating new problems.  We will provide improved indicators for BD relevant to the Conv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Thermodynamics of Mesoscopic Quantum Systems' (TherMiQ) targeting Seventh Framework.

assistant: **Abstract**

A quantum technology going beyond microscopic borders will be confronted with aspects of thermodynamics that are yet to be understood. This is important, both from a fundamental perspective and with a view to development of quantum devices. Here we propose a comprehensive research programme -- which we dub TherMiQ -- aimed at developing a general framework that brings together thermodynamics and the physics of mesoscopic open quantum systems. The programme builds on an active interplay between theoretical and experimental work. Specifically, we pursue three scientific lines:1. To provide unambiguous definitions of thermodynamical quantities that are genuinely quantum.2. To construct mesoscopic thermal engines able of realising heat, mass and entropy transport at the quantum level.3. To test the foundations of quantum mechanics through thermodynamical concepts.TherMiQ will provide the theoretical backbone for a new generation of experiments in mesoscopic systems. In particular, we will focus ona) Entropic transformations and heat exchange processes in quantum-optomechanical devices and their hybridized versions comprising the interface with simple atomic systems and levitating nanoparticles;b) The construction of thermodynamical cycles and super efficient machines using ultracold atoms placed in controllable optical potentials;c) The design and implementation of schemes for thermometry of strongly correlated quantum systems through novel diagnostic tools.Our programme will build on an information-theoretical approach and aims to provide a clear route towards the development of a self-consistent, experimentally viable apparatus for exploring and eventually exploiting quantum thermodynamics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemoenzymatic routes of improved polyene antifungal agents' in the context of a Horizon Europe call.

assistant: **Objectives**

Fungal infections are an increasingly serious global health threat, driven by rising antimicrobial resistance (AMR) and a critical lack of new antifungal drugs in development. Currently, treatment relies heavily on Amphotericin B (AmB) and a small group of related polyene natural products. However, the clinical use of these compounds is limited by their poor solubility and significant toxicity. Research has shown that chemical modifications of polyenes like AmB can reduce their toxicity, but traditional synthetic approaches to producing these derivatives are far from ideal. These methods typically involve multiple, low-yielding steps, making them costly, environmentally unfriendly, and difficult to scale. Moreover, they often rely on heavy metals, hazardous reagents, and extensive use of protecting groups—practices that conflict with the principles of green chemistry, including step- and atom-economy. The CERIPA project aims to address these challenges by developing cleaner, more efficient, and sustainable chemoenzymatic approaches to modifying polyenes. Our goal is to generate new derivatives with enhanced antifungal activity, reduced toxicity, and improved solubility. We plan to diversify polyene structures by using a newly discovered family of glycosyltransferases to attach non-native sugar moieties at specific sites. Additionally, we will explore the use of other polyene-modifying enzymes to further tailor the molecular backbone. These newly engineered polyene analogues will undergo rigorous bioactivity and toxicity testing to establish structure–activity relationships (SARs), guiding the rational design of next-generation antifungal agents.


**Keywords:** Chemoenzymatic synthesis, Glycosyltransferases, Amidotransferase, Modified polyenes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Self-aligned high-resolution organic ferroelectric transistor based complementary memory' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Soft-COM project proposes to realize a self-aligned fabrication of non-volatile, reprogrammable organic complementary memory cell (CMC) compressing both p- and n- channel organic ferroelectric thin film transistor (FTFT).Non-volatile memory applications based on organic materials have recently been of great interest due to their potential integration into products ranging from low-cost identification tags to switching devices for active matrix display.  Among all demonstrated memory devices organic ferroelectric field-effect transistor (FTFT) has drawn great attention for its non-destructive read-out, non-volatile, and compatibility of integrating with other organic circuits etc. Although such device is very attractive for many merits but its real application is hindered by several problems, such as high fabrication cost, high power consumption occurs during the read operation when the channel of the transistor is in the on state.  Thus, a new design of organic FTFT based device that can be fabricated by low cost method with reasonably high resolution is highly desired. Herein, a complementary design of memory device fabricated with “all self-alignment process” and compatible organic complementary circuit will be demonstrated.  The complementary devices comprise both p- and n-channel organic FTFT to ensure a minimized current flow for reading. All components of the organic FTFT including transistor channels, both p- and n-type of semiconductors, and gate are patterned by all self-aligned process without mask alignment. Whole process, like device design, fabrication, and characterization, will be achieved in a feasible and credible way with in the knowledge and experiences that the candidate has obtained before and will acquire in the proposed project through the syn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transient inactivation of hypothalamic hormone release to prevent post-traumatic stress sensitization' (SECRET-DOCK).

assistant: **Concept**

Stress is the foremost consequence of human life and became a pressing societal burden through the many sensory and societal pressures that have evolved during the past decades. Severe stress induces maladaptive changes in the brain that clinically manifest as post-traumatic stress disorder (PTSD). Despite ~4% of the population presenting PTSD, only symptomatic therapies are available. In the ’SECRET-CELLS’ ERC award, we have identified a multimodal neurocircuit that induces brain-wide sensitization to stress through the sequential recruitment of hypothalamic, midbrain and then cortical neuronal circuits. Particularly, we identified protein targets that can simultaneously affect hormone and neurotransmitter release within this circuit and whose knock-out makes mice stress resilient. Therefore, we used unbiased proteomics to select protein interactors that participate in the related signaling cascades, determined the biochemical parameters of any such interaction and the X-ray structures of the relevant protein complexes. Moreso, a high-throughput screen was established to identify inhibitors. Here, we will apply this knowledge to use interacting proteins as templates for small-molecule inhibitor discovery and hit optimization. Subsequently, we will profile the pharmacology and cytotoxicity of the candidates in vitro. Thus, we will take critical steps towards developing a ‘circuit breaker’ that can inactivate the neuronal contingents that are causal to the development of PTSD. Thereby, we will offer a fundamentally novel framework for pharmacotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a biotechnological high yield process for ethanol production, based on a continuous fermentation reactor' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Fermentation is the limiting step in alcohol production using agricultural sub-products and it as been performed in batch, low yield reactors. The main objective of this project is to develop a continuous Fluidised- Bed Bioreactor -Three Phase (FBR -3P) with higher fermentation yields, that will be scaled-up and tested at semi-industrial level. A new configuration of FBR-3P, working in down- flow, will be tested, including selection of a suitable solid phase for good inoculate immobilisation. Also, a mixed inoculums of Simmons Mobilise and Saccharomyces Cerevisiae will be tested. With FBR-3P, productivity should reach values from 25 to 28 g Ethos /L.d , which means from 5 to 10 times comparing with existent batch processes, with less energy requirement. It will be possible to recover evaporated alcohol and also a big amount of carbon dioxide as a sub-product. This proposal fits in European politic of substitution of fossil fuels and valuable recovery of agricultural sub-products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rail Infrastructure Systems Engineering Network' to be submitted under Horizon 2020.

assistant: **Abstract**

Social and economic growth, security and sustainability in Europe are at risk of being compromised due to aging and failing railway infrastructure systems. This partly reflects a recognised skill shortage in railway infrastructure engineering. This project, RISEN, aims to enhance knowledge creation and transfer using both international and intersectoral secondment mechanisms among European Advanced Rail Research Universities/SMEs and Non-EU, world-class rail universities including the University of Illinois at Urbana Champaign (USA), Massachusetts Institute of Technology (USA), Southwest Jiaotong University (China), Tsinghua University (China), University of California Berkeley (USA), Railway Technical Research Institute (Japan), University of Sao Paulo (Brazil), Iranian University of Science and Technology (Iran), Chulalongkorn University (Thailand), and University of Wollongong (Australia). This project adds research skill mobility and innovation dimension to existing bilateral collaborations between universities through research exchange, joint research supervision, summer courses, international training and workshops, and joint development of innovative inventions. It spans over 4 years from April 2016 to March 2020. RISEN aims to produce the next generation of engineers and scientists needed to meet the challenge of providing sustainable, smart and resilient railway infrastructure systems critical for maintaining European competitiveness. The emphasis will be placed on the resilience and adaptation of railway and urban transport infrastructures using integrated smart systems. Such critical areas of the research theme will thus be synergised to improve response and resilience of rail infrastructure systems to climate change, extreme events from natural and human-mad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chirality detection enabled by colossal optical anisotropy of 2D layered materials' under Horizon Europe.

assistant: **Concept**

Molecular chirality plays a fundamental role in pharmaceuticals, toxicology, and environmental sciences, as enantiomers of the same molecule can have vastly different biological effects. Current chiroptical detection methods, such as circular dichroism and Raman optical activity, require complex, expensive setups with limited sensitivity, often making real-time and field applications impractical. The 2Dchiral project aims to revolutionize chiral detection by leveraging the colossal optical anisotropy of novel 2D materials to create fiber-based chiroptical probes. These functionalized optical fibers will replace bulky polarization optics, improving compactness and portability together with enhancing detection sensitivity by over 10X while reducing costs by 2 – 5X.Our approach is based on the principle that chiral interactions can be significantly amplified if the illuminating light’s polarization state is tailored to match the symmetry of the target molecule. Instead of using conventional circularly polarized light, we will design custom polarization states via 2D-material-integrated optical fiber probes, ensuring optimal enantiomer-specific signal enhancement. This will enable fast, real-time enantiomeric discrimination in pharmaceuticals, environmental monitoring, and food safety.The potential impact is significant: improved enantioselective drug screening, detection of chiral pollutants, and real-time quality control in food and chemical industries. Through IP protection, commercialization strategies, and industry engagement, 2Dchiral aims to establish a new standard for low-cost, high-precision chiral analysis, democratizing access to advanced optical sensing worldwide.