RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEXTAIR - multi-disciplinary digital - enablers for NEXT-generation AIRcraft design and operations' (NEXTAIR), addressing dissemination and exploitation.

assistant: **Impact**

Radical changes in aircraft configurations and operations are required to meet the target of climate-neutral aviation. To foster this transformation, innovative digital methodologies are of utmost importance to enable the optimisation of aircraft performances.NEXTAIR will develop and demonstrate innovative design methodologies, data-fusion techniques and smart health-assessment tools enabling the digital transformation of aircraft design, manufacturing and maintenance. NEXTAIR proposes digital enablers covering the whole aircraft life-cycle devoted to ease breakthrough technology maturation, their flawless entry into service and smart health assessment. They will be demonstrated in 8 industrial test cases, representative of multi-physics industrial design, maintenance problems and environmental challenges and interest for aircraft and engines manufacturers.NEXTAIR will increase high-fidelity modelling and simulation capabilities to accelerate and derisk new disruptive configurations and breakthrough technologies design. NEXTAIR will also improve the efficiency of uncertainty quantification and robust optimisation techniques to effectively account for manufacturing uncertainty and operational variability in the industrial multi-disciplinary design of aircraft and engine components. Finally, NEXTAIR will extend the usability of machine learning-driven methodologies to contribute to aircraft and engine components' digital twinning for smart prototyping and maintenance. NEXTAIR brings together 16 partners from 6 countries specialised in various disciplines: digital tools, advanced modelling and simulation, artificial intelligence, machine learning, aerospace design, and innovative manufacturing. The consortium includes 9 research organisations, 4 leading aeronautical indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'METAclustering for cross-sectoral and cross-border innovation ecosystem BUILDING for the European Construction, Additive Manufacturing and Nature-Based Solutions industrial sectors’ SMEs' (METABUILDING).

assistant: **Innovation**

The EU construction industry is challenged to boost innovation of SMEs (99% of companies) inside a traditional sector, to expand its value chain and integrate new dynamic industrial sectors. The European Construction Technology Platform (ECTP) is joining efforts with 4 industrial sectors: ICT, Additive Manufacturing, Nature Based Solutions, and the Recycling industry, to underpin and fuel the emergence of new cross-sectoral, cross-border industrial value chains, delivering a metaclustering process to achieve critical mass and boost internationalisation. To reach Clusters and their SMEs in their business environment, METABUILDING will achieve a sustainable and expandable collaborative innovation ecosystem backed by an open innovation digital platform performing 6 main functions: 1) Cross-sectoral/border Digital Marketplace; 2) interactive Knowledge Repository; 3) Industrial commons database with technology assets from EU funded R&D, 4) Business Strategy resourcing, 5) Innovation Funding Scaling knowledge support and 6) Metaclustering Network Management. MB will nurture, mentor and technically assist SMEs and implement several cascade funding mechanisms, achieve at least 140 cross-sectoral, cross-border challenge-based SME-led innovation ideas/projects coming from regional clusters in 6 target countries: Austria, Spain, Portugal, France, Italy and Hungary. Coordinated by an experienced construction sector RTO, MB will feature: 6 Metaclusters working with 4 EU level R&D roadmapping institutions (ECTP, AM Platform, EuRic and EFB) and 90 clusters with reach to more than 9000 SMEs; 3 National Technology Platforms, 1 national Construction Federation, 1 Industrial Association and 1 Business Network to build an EU level enlarged innovation Ecosystem and value chain with actors i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced hybrid methods for electromagnetic field computation' (1994-1998).

assistant: **Concept**

Research objectives and content Development of generic mathematical and computational techniques to combine finite element time domain and integral equation (boundary element) time domain methods in a hybrid approach for large electromagnetic field computations is proposed. Such hybrid methods will offer a step increase in size and range of devices which can be modelled. The need for such an increase in modelling capability arises from growing concern over electromagnetic (EM) compatibility, over health effects of EM radiation, and the greater emphasis on the EM performance of industrial products ranging from automobiles through computers to aerospace. Training content (objective. benefit and expected impact) I have a strong theoretical background in physics and associated mathematical and analytical techniques. I hope through this research to broaden, using this background on a practical, applied problem. My longer term intent is to research in the area of applied science / engineering, and I believe this research placement, in a group with a strong analytical base, but with extensive industrial involvement, will provide an ideal starting point. Links with industry / industrial relevance (22) The industrial relevance of development of such computational capability is clear from the extensive support in this area received by the group I plan to join. Further, the specific research is based on the FETD approach developed by one of the group's industrial collaborators. Another industrial partner is MSC Nastran, developers of the CAD suite, to be used for geometry definition, meshing and postprocessing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ERA-Net on Rare Diseases' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Rare diseases represent an important public-health issue, affecting 26-30 million persons across Europe, and a major challenge for research. The fragmentation of resources and knowledge for the 6000-8000 rare diseases and the lack of treatment for the majority of them necessitate a coordinated European approach to unravel the underlying molecular defects and pathophysiological mechanisms. The low number of affected patients requires transnational collaboration with multidisciplinary approaches to map prevalences, build patient registries, identify biomarkers, develop new diagnostics and finally perform clinical studies for the development of treatments. The successful linking of research funding organisations in E-Rare-1 and the subsequent exemplary joint funding activities have attested the need of, and the acknowledgment from, the research community for transnational funding of collaborative, multidisciplinary and ambitious projects on rare diseases. It has leveraged funding for rare disease research in countries without specific programmes for rare diseases and thus enabled the participation of researchers in these countries to transnational projects. The E-Rare-2 project aims at deepening and extending the cooperation among the E-Rare-1 and the five new partners by systematic exchange of information, yearly launching of joint calls, thorough assessment of the funding mechanisms and results of the funded research projects and, finally, strategic activities aiming at a sustainable development and extension of the network. Special attention will be given to the outreach and knowledge exchange with new member states, countries outside of Europe and key stakeholders/initiatives important for rare diseases. E-Rare-2 activities will thus further contribute to reducing frag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Study of the molecular mechanisms that regulate SCN5A expression'.

assistant: **Concept**

Sudden cardiac death syndromes are an important cause of mortality in young individuals in developed countries. The SCN5A gene, which encodes the alpha subunit of the cardiac sodium channel, plays a key role in controlling the sodium currents during the action potential. When malfunctioning due to loss-of-function genetic defects, SCN5A may be responsible for lethal diseases like Brugada syndrome or familial conduction disease. However, little is known regarding SCN5A gene expression regulation, both at the transcriptional or posttranscriptional level. In this project I am  proposing to further elucidate the molecular mechanisms that regulate the expression of the SCN5A gene. Using in vitro, cell culture and in vivo experimental approaches, I propose to study the following objectives: 1) To characterize the transcription factors implicated in the transcriptional regulation of the SCN5A promoter in cell culture, EMSA and ChIP experiments; 2) To study the role of DNA methylation in SCN5A expression by analyzing the presence of methylated DNA in cardiac cell derived genomic samples from a cohort of individuals; 3) To study the role of microRNAs with putative binding sites at the 3’UTR of the regulatory region of SCN5A to the cardiac sodium channel. We anticipate that these studies will bring new insights and better understanding of promoter regulation and sodium channel expression. Because of the clinical relevance of this cardiac channel in many arrhythmias, we predict that these studies will have an impact for the future diagnosis and treatment of patients with cardiac arrhythmias and sudden cardiac death syndromes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of three dimensional coronary blood perfusion model in beating heart using advanced computational and experimental techniques.'.

assistant: **Objectives**

Coronary vascular disease(CVD) has been studied for many decades and has been found to be a very complex problem.Despite dramatic medical advances over the last few decades, CVD remain a leading cause of death globally and thenumber one cause of death in the European Union (EU). Inspite of the tedious and creative work by many expert scientistsfrom many different perspectives, the disease has only partially been understood. The approach that is taken here differs inbasic tenets from earlier approaches, in that it starts from a very basic system of study inorder to progressively build higherlevels of complexity. It is understood that the vast majority of the life threatening pathologies are associated with animbalance between the demand in oxygen and the supply provided by the RBCs. This project will start studying the structureof the microvascular geometry and upscale the coronary circulation from there. The microvascular bed will be embedded intoa beating heart with all complexities associated with it:contracting muscle fibre, complex fibre architecture, valves, coronaryarteries and veins, etc. On that level, the project will multi-stage and multiscale with finite element (FE) modelling ofmyocardial contraction, deformation and perfusion. The interdisciplinary perspective in this study is strong with contributionsfrom engineers, clinicians and biomaterial scientists. The scope of the study is usage of FE modelling for autoregulation ofcoronary perfusion which extends the applications of FE model to common pathologies such as ischemic heart disease,infarction or reperfusion issues and devices such as stents or cardiac assist devices, that improve coronary blood perfusion.This project is in line with the European heart health charter to promote research in the field of c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Establishment of novel targets for risk assessment and monitoring of xenogeneic infections in the course of animal to human transplantation', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

This proposal is aiming at a certain number of issues including European Public Health, ethics and economy. Particularly, specifically designed strategies for patient surveillance in order to detect and control putative xenozoonoticinfections shall be developed. Those include PRC based techniques (ultrasensitivereal-time PRC) and specific antibody detection tools (natural virus proteins and recombinant proteins and peptides for ELISA and Western blot assays) for patient surveillance in order to detect and to control putative xenozoonotic infections shall be developed. At current, established regulatory guidance on animal production for xenotransplantation and the validation of European standards of animal health and welfare and risk assessment of possible transmission of diseases from pig to man in the course of transplantation of porcine tissues and whole organs is missing. Novel detection essays will be a prerequisite for defining such guidelines on a European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The tumor microbial communities: Characterization, effects and translational opportunities' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The human body is host to a huge number of bacteria. While bacteria were first detected in human tumors over 150 years ago, our knowledge about their number, identity or effects in different human tumor types is still mostly rudimentary.Over the last few years we focused on studying the tumor microbiome. We developed multiple methods to characterize and visualize intra-tumor bacteria, taking special measures to tell apart true tumor-bacteria from contamination. Profiling over 1,800 human tumors and normal adjacent tissues demostrated that bacteria are prevalent in many tumor types and that each tumor type has a unique microbial signature.This application aims to capitalize on our cutting-edge research tools, vast experience and comprehensive preliminary data to shed light on the uncharted field of the tumor microbiome. We plan to: (1) Characterize  the different microbial communities (bacteria, fungi, others) and their dynamics in human tumors. We strive to provide a near complete narrative of how bacteria are distributed in the tumor, their association with immune cells and their dynamic changes with tumor development, metastasis and drug treatments.(2) Study the effects that microbial communities may have on tumor biology, focusing primarily on tumor microbiome-mediated drug resistance and on tumor microbiome effects on tumor-associated macrophages.(3) Exploit intra-tumor microbial communities for translational opportunities and novel therapeutics, in particular as an adjunct to current mainstay therapy or delivering innovative therapeutics via live bacteria. Thus, this project will transform our understanding of the structure and function of intra-tumor microbial communities and will pave the way for us, as well as many others, to translate our findings into novel th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Function of Chemosensory Circuits' under Seventh Framework.

assistant: **Concept**

Smell and taste are the least studied of all senses. Very little is known about chemosensory information processing beyond the level of receptor neurons. Every morning we enjoy our coffee thanks to our brains ability to combine and process multiple sensory modalities. Meanwhile, we can still review a document on our desk by adjusting the weights of numerous sensory inputs that constantly bombard our brains. Yet, the smell of our coffee may remind us that pleasant weekend breakfast through associative learning and memory. In the proposed project we will explore the function and the architecture of neural circuits that are involved in olfactory and gustatory information processing, namely habenula and brainstem. Moreover we will investigate the fundamental principles underlying multimodal sensory integration and the neural basis of behavior in these highly conserved brain areas.To achieve these goals we will take an innovative approach by combining two-photon calcium imaging, optogenetics and electrophysiology with the expanding genetic toolbox of a small vertebrate, the zebrafish. This pioneering approach will enable us to design new types of experiments that were unthinkable only a few years ago. Using this unique combination of methods, we will monitor and perturb the activity of functionally distinct elements of habenular and brainstem circuits, in vivo. The habenula and brainstem are important in mediating stress/anxiety and eating habits respectively. Therefore, understanding the neural computations in these brain regions is important for comprehending the neural mechanisms underlying psychological conditions related to anxiety and eating disorders. We anticipate that our results will go beyond chemical senses and contribute new insights to the understanding of how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'VISUALIZATION FOR EXTREMELY LARGE-SCALE SCIENTIFIC COMPUTING' to be submitted under Seventh Framework.

assistant: **Abstract**

VeLASSCo will provide new visual analysis methods for large-scale simulations serving the petabyte era and preparing the exabyte era by adopting Big Data tools/architectures for the engineering and scientific community, leveraging new ways of in-situ processing for data analytics and hardware accelerated interactive visualization.Regardless of its origin, in the near future the challenge will not be on how to generate data, but rather in how to manage big and highly distributed data to make it easily handled by users in their personal devices. In the case of simulation data, the extraction of the specific useful information for analysis requires the treatment of large amounts of the data generated by the simulation, such as data for each time step, entire volume results when only some cuts are needed, etc..The global goal of VELaSSCo is to provide Big Data tools, for the engineering and scientific community in order to better manipulate simulation with billions of distributed records.In large-scale simulations the domain is partitioned across several thousands of nodes, and the data (mesh and results) is stored on those nodes in a distributed manner. The VELaSSCo platform to be developed in this project will access this distributed information, will process it and send the results back to the users for local visualization by their specific visualization clients and tools (GiD from CIMNE, iFX from Fraunhofer, or other).Based on the layered structure commonly used in the Big Data field, the architecture of VELaSSCo platform is based on three layers:- Service layer: it is the communication point between the platform and the user's visualization client, responsible of classifying user queries and send the results back. It will ensure access to the distributed data and provi