RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Recombinant Pharmaceuticals from Plants for Human Health' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Plants are attractive vehicles for the expression of recombinant pharmaceutical proteins as they are inexpensive and versatile systems, amenable to rapid and economical scale-up. Public opinion in Europe is generally negative towards GM plants, which has led to the loss of many SMEs and commercial development from the Union. However, the use of GM plants for medicines and vaccines rates very highly in terms of public acceptance. With this proposal, our primary aim is to build on previous proof-of-concept studies to develop pharmaceutical products through to clinical trials. The use of GM pharmaceuticals has precedents, such as human insulin and hepatitis B vaccine, but plant-derived materials used in humans has not been formally addressed within the EU. A major outcome will be to define the regulatory requirements through a process of engagement and consultation with all relevant regulatory bodies (involved in GM plants as well as new pharmaceuticals), in order to move through clinical trials and gain permission for the use of plant derived pharmaceuticals in practice. Monoclonal antibodies will be the first generation of molecules to be developed for Phase I clinical evaluation, and we include 2 neutralising antibodies each for HIV and rabies. The proposal also includes a limited range of other targets, against HIV, TB and diabetes, and for some of these, new expression strategies will need to be developed. They represent the second-generation molecules, which will feed the development pipeline for SMEs in Europe, beyond the lifetime of the project. In each case, plant-based systems offer a real advantage, if not the only option for production on a scale relevant to the needs for that molecule. Alongside our principle aim of developing plant derived recombinant pharmac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The importance of the epigenome in tumour development and recurrence' under Seventh Framework.

assistant: **Concept**

I aim to develop methods to reverse epigenetic anomalies in cancer stem cells (CSCs) to switch off the unlimited cell division and cancer growth and to understand the involvement of epigenetics in tumour development and recurrence. Epigenetic alterations are observed at the earliest stages of neoplasia within stem cells. Importantly, the alterations are reversible and can potentially be “treated”. In children, brain tumours are the leading cause of cancer-related mortality and morbidity. There are severe side-effects from treatment and survivors often experience substantial long-term problems. In vitro cultures of CSCs are indispensable tools for functional analyses and development of new therapies. However, up to now, paediatric CSC cultures have not been available. My unique cultures now enable us to study this disease closer. Induce differentiation of the CSCs will turn them less proliferative and less tumourigenic. Hence, I will screen for drugs that induce differentiation and determine the role epigenetics has on the stability of the specific differentiation stages. In addition, I will explore the relevance of the epigenome in tumour development by removing epigenetic marks through reprogramming the cells into induced pluripotent stem cells. These analyses will highlight target genes and pathways that are involved in the differentiation process. Furthermore, biomarkers will be implemented and I will study radiation-induced long-term effects to increase survival, quality of life and reduce adverse side-effects from treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Safe and high quality food supply chains and networks - establishing an international research knowledge network on cross-border food supply chains and networks' (SAFEACC) targeting Fifth Framework.

assistant: **Abstract**

The aim of the concerted action is: - to build a sustainable international platform for the exchange and development of knowledge on cross-border supply chains and networks for safe and high quality food. The platform will consist of national networks of public and private organisations (universities and research institutes, governmental and business organisations) from emerging economies (LAM countries )developing economies (ACP countries) and developed economies (EU countries). - to enable the consortium to develop internationally attuned research agenda's to support research and development of balanced and sustainable food supply chains and networks between EU countries and LAM and ACP countries. It is a three year project in which national, regional and international workshops are major milestones to achieve goals. Besides the knowledge exchange network and the research agenda's the concerted action will deliver a sustainable and extendable communication structure and web site. Coordination takes place by the project co-ordinator in collaboration wig region co-ordinators (for EU, ACP and LAM countries).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A laser made entirely of living cells and materials derived from living organisms' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The aim of this proposal is to make a laser composed entirely of living cells and materials derived from living organisms. The central part of the laser will consist of human embryonic kidney cells engineered to produce enhanced green fluorescent protein. The cells will provide gain for the laser. The resonant cavity will be made in three different ways, either using butterfly wings as highly reflective mirrors or using a droplet of water to circulate light or by highly scattering particles that will induce random lasing. This project goes well beyond bio-inspired technologies, which are based on principles from nature, but use artificial materials. A step forward is to use biocompatible materials or materials derived from living organisms. By using live cells this proposal goes even further. The advantage of this concept is self-assembly, self-healing, self-reproduction, scalability, self-reproduction, evolvability and adaptability of such living laser. The use of the living laser spans a variety of possible applications. The lasing spectrum emitted by the living laser has a unique pattern, which can be used to study the processes in the cell as well as for sensing external substances affecting the cell. We also suggest possible medical applications. Doctors today shine lasers into the body to gather images or to treat disease. The living lasers could instead generate or amplify the light inside the body, so it could penetrate the relevant tissues more deeply. Finally, future optical circuits could be made entirely of living tissues enabling their integration into living organisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ammonia losses from field-applied animal manures' in the context of a Fourth Framework call.

assistant: **Objectives**

Volatilization of ammonia is a major route for the loss of plant-available nitrogen from animal manures, representing a financial loss to European farmers of about ECU 650 million/year. These losses also cause environmental problems animal production systems are the main source of atmospheric ammonia in Europe. Concern at the impact of ammonia deposition on sensitive ecosystems forms the background to ongoing international negotiations to reduce national ammonia emissions. Ammonia losses vary greatly with application technique and weather and are one reason why farmers cannot effectively predict the fertilizer value of the animal manure nitrogen. This leads to a tendency to apply a surplus of nitrogen to the crop, contributing to nitrate and nitrous oxide pollution. European agriculture of the future must be competitive within the world market place, whilst protecting natural resources.  To achieve this objective, manure management strategies and technologies are required that enable environmental targets to be met, whilst minimising the associated costs. Appropriate strategies and technologies will vary across Europe, as climate and production systems vary. Currently, national guidelines for best agricultural practice are often based on relatively few field scale studies of ammonia volatilization. The value of national research programmes would be greatly increased if their data were related to results from elsewhere in Europe. New studies would have added value if there was international co-ordination of experimental structure and standardisation of techniques. Bringing together experts on NH3 emissions would enable cost-effective reduction methods to be identified, improve the efficiency of manure N use in agriculture and help reduce overall losses of N from field-ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Calcium Propagation in Atrial Fibrillation' to be submitted under Seventh Framework.

assistant: **Abstract**

Synchronized release of Ca2+ from the internal Ca2+ store of cardiac myocytes, the sarcoplasmic reticulum, is essential for a normal heart beat. This is obtained through a sophisticated subcellular organization, the dyad. In dyads, a cluster of release channels in the sarcoplasmic reticulum, ryanodine receptors or RyRs, face Ca2+ channels in the cell membrane, the dihydropyrydine receptors or DHPRs. DHPRs provide the Ca2+ influx that triggers opening of RyR. Ca2+ release can also propagate between RyR, leading to Ca2+ waves that can initiate arrhythmias. We hypothesize that RyR that are not within dyads have different properties that may facilitate wave-like propagation and arrhythmias. The objectives are (1) to identify and characterize RyR located between dyads in the sarcomeric space in healthy myocytes (2) to establish whether altered organization and properties of RyRs in chronic atrial fibrillation (AF) contribute to the contractile dysfunction and arrhythmia in AF. My stay in the host lab will provide a clinical and translational perspective to my current knowledge enhancing the potential impact of my research. An interdisciplinary approach for imaging of RyR with access to novel microscopic techniques in the Molecular engineering department and tools for image analysis with the Medical Imaging Center and ESAT will enhance my technological expertise.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'For the Benefit of All? Re-evaluation of Intersectionality in Gentrification Processes'.

assistant: **Concept**

The dominant stream of Urban Studies research links ethnic or racial marginalization and class-based marginalization resulting out of gentrification processes. But in doing so, it overlooks a more complex relationship between class and ethnicity and cases in which gentrification is led by middle-class ethnic groups. In particular, there is limited research into the conditions within which class affiliation and interests may overcome considerations of ethnicity. Thus, there are even fewer studies focusing on the consequences of such processes for inter- and intra-ethnic relations. The current study takes the critical stance that without a more precise and intersectional lens, research may fail to acknowledge the potential benefits of gentrification for middle-class ethnic groups. Moreover, efforts to tackle the inequalities experienced by minority residents of gentrifying neighborhoods are themselves likely to perpetuate systems of inequalities towards working-class ethnic populations. To address this research gap, the aims of the proposed project are: (1) To map, describe, and categorize ethnic/racial-led gentrification in US cities;(2) To explore the relationship between class and ethnic affiliations in the case of ethnic-led gentrification; and (3) To examine and theorize patterns of resistance and promotion in relation to ethnic-led gentrification. The research project will employ a qualitative in-depth case study approach, encompassing a preliminary review of existing literature of ethnic/racial-led gentrification in US cities. The research will take the form of an in-depth analysis of Barrio Logan, a Latinx neighborhood in San Diego currently experiencing ethnic-led gentrification. The case study will be directed by various qualitative methods. Data analysis will i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fault-rupture and strong-shaking effects on the safety of composite foundations and pipeline systems: quantification and reduction of seismic risk through the application of advanced geotechnical engineering techniques.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

QUAKER will reduce the human and economic cost of earthquakes by quantifying and reducing seismic risk through the application of advanced geotechnical engineering techniques. New understanding of the behaviour of foundations and lifeline systems in strong earthquakes will be obtained using a range of techniques. Field assessment of recent earthquakes, state-of-the-art reduced scale modelling and advanced numerical modelling, coupled with theoretical analysis. New methods of analysis for use in seismic risk assessment and for the design and retrofitting of infrastructure will be developed. Use in practice, and thereby reduction of seismic risk will be achieved by effective dissemination. Specific end-users will participate in steering the project and, together with two SMEs in the partnership, implement its findings first. Findings will be disseminated by book, international workshop and by incorporation into Eurocodes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pulsed Corona discharge Tar Cracker for thermally generated bio gas' (PC-TAC), addressing dissemination and exploitation.

assistant: **Impact**

PROJECT OBJECTIVES Goal of the project is to offer a specific gas treatment method for thermally generated bio gas. To supply combustion engines or gas turbines it is necessary to clean the bio gas. Contaminants such as tar, NH3, H2S and alkalis are detrimental to machine components and will strongly affect maintenance costs. The proposed method would avoid mechanical filters. It can operate at the high temperature of a gasifier (900 C) and it is adaptable to varying compositions of input gases and various sizes of bio gas plants. It needs no gas conditioning, has a multiple cleaning effect and avoids any further waste. TECHNICAL APPROACH An intensive cleaning effect in composed gases can be obtained from the special process called pulsed corona. Pulsed corona is a discharge type that runs reliably at low and at high temperatures in gasses with a wide range of parameters and compositions. It produces a non-thermal high power plasma that liberates electrons and that initiates complex oscillations of molecules, strong UV irradiation and deposition of electrical charges at solid and liquid particles. The high power density and UV radiation lead to a thermal, chemical and photolytical cracking of larger molecules and production of radicals. Additionally there may also be the effect of particle removal similar to an electrostatic gas filter. Gas coming from the gasifier will pass the gas discharge reactor. If it gets through the electrodes a capacitor will be charged very fast until the start of the breakdown of the interelectrode gap. To get a homogeneous discharge into a gas volume it is necessary to apply a preionisation of the interelectrode gap for example with UV irradiation from a couple of spark discharges. The technology is similar to impulse gas lasers. EXPECTED AC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Geothermal Communities – demonstrating the cascading use of geothermal energy for district heating with small scale RES integration and retrofitting measures' to be submitted under Seventh Framework.

assistant: **Abstract**

Central-Eastern European countries have exceptional geothermal resources. These resources are either unexploited due to the lack of technological know-how or their utilisation is carried out in an unsustainable way; geothermal district heating projects lack the energy efficiency component and the used thermal water is not reinjected but instead released to surface waters. Geothermal Communities will demonstrate best available technologies in the use of geothermal energy combined with innovative energy-efficiency measures in three different pilot sites (Hungary, Slovakia and Italy). Furthermore the project will integrate a large number of cities as project partners (from Serbia, Romania, Poland and Italy) that either already have ongoing geothermal systems that needs the adoption of new technologies (e.g. Sacueni, Romania) or they would like to implement new systems from scratch with the help of the project partners (e.g. Subotica, Serbia). In addition to the demonstration component through the parallel implementation of three ambitious development works there is also a strong complementary component of research focusing on making geothermal projects more cost efficient and technologically sound. Results of the project activities will be disseminated via straightforward dissemination actions combined with a training programme organised for municipal-level decision makers. Finally, the Mayors’ Geothermal Club will be set up and will continue operating even after the EC-funded period as a permanent network of city mayors and municipal-level decision makers who are interested in the sustainable utilisation of geothermal energy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cargo Beacons – no unexpected delays or losses in shipments of valuable cargo' (2014-2020).

assistant: **Concept**

Hiotech is an innovative Swedish SME whose ambition is to solve a pressing logistics challenge – to make damages or losses to valuable cargo known to the stakeholders before the goods arrive, so that corrective measures could take place with least impact on manufacturing and supply chains.Realizing that globally almost €90B worth of goods are mishandled or damaged every year, and that there are market segments with stringent requirements on transportation (such as industrial equipment parts or medical substances), Hiotech designed Cargo Beacon – a compact, ruggedized logger of temperature, humidity and shocks. Cargo Beacons are designed to be long-lasting, highly-reusable and low cost – with manufacturing costs at €10 they pose a serious competitive threat to existing loggers with less functionality and a price tag of €100-500.Cargo Beacons communicate their measurements via a dedicated gateway that connects them to a cloud-based data services portal. These services provide additional analytics to the goods owners & recipients and logistics operators. These services include identification of damage cause, optimization of goods flows, reduction of bottlenecks and others. Cargo Beacons are currently on trial with Nefab Group – a packaging solutions OEM, with additional trials pending.During the 6-month feasibility study, Hiotech will validate further the product/market fit of Cargo Beacons in industrial equipment and medical substances markets, and will seek endorsements of this technology from insurance companies that frequently need evidence that goods were transported in full compliance with signed contracts and no damage or wastage took place.