RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bacteriophage inhibition of antibiotic-resistant pathogenic microbes and founding for novel therapeutic strategies'.

assistant: **Innovation**

Emergence of antimicrobial resistance (AMR) is a grand scientific challenge of our time that has killed more than 700,000 people worldwide.  Phage therapy, a promising complement to antibiotics, utilizes viruses of bacteria (bacteriophages) or phage-derived inhibitors as natural ways to fight AMR.  The main obstacles in the clinical application of phage-based AMR therapy are the limited number of phage isolates and the unknown molecular mechanisms of phage-delivered bactericidal action.  Building on the recent advances of my group in high-throughput, culture-independent but host-targeted methodologies, PHARMS aims to deploy a revolutionary approach: to screen for all possible phages of a resistant bacterial isolate, characterize multiple lines of their bactericidal functions, and use this information for the design of a whole battery of phage-based therapies that employ multifaceted modes of action.  Using an interdisciplinary research plan, PHARMS will discover phage-specific bactericidal action modes at all possible levels ranging from nucleotide sequence and transcription to translation, in order to elucidate the molecular mechanisms driving phage-mediated inhibition of AMR Acinetobacter baumannii, Helicobacter pylori, & Haemophilus influenzae (WP1). These discoveries, together with novel synthetic biology tools, will enable us to engineer an array of phage vectors that mimic phage-deployed bactericidal modes discovered under WP1, including transport of alien genes to deliver bactericidal effects (WP2).  PHARMS will provide molecular confirmation and in vitro & in vivo validation of the functions of phage-encoded bactericidal peptides and enzymes (WP3).  By elucidating universal and specific mechanisms of phage-delivered inhibition of AMR pathogens, PHARMS is positio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Vision Restoration with optogenetic tools'.

assistant: **Objectives**

Blindness is one of the most devastating conditions affecting the quality of life in developed countries, especially in Europe. No treatment is known today for retinal degenerative diseases, such as retinitis pigmentosa or macular degeneration. They are hereditary diseases characterized by the progressive loss of photoreceptors, leading to complete blindness. Recent discoveries of optical neuromodulators, such as channelrhodopsin-2 (ChR2) or halorhodopsin (NpHR), have opened up new possibilities of treating these diseases by imparting light-sensitivity to the remaining retinal neurons after the photoreceptors have died. During my previous Marie Curie postdoctoral fellowship, I have shown in a proof-of-concept study that this approach is feasible. We used a mouse model of retinal degeneration (rd1) and introduced ChR2 specifically in ON bipolar cells of the retina, upon which the animal regained retinal light responses, light-guided behavior, and form vision.Here, I propose to test several optogenetic strategies of treating blindness. This includes the use of several different mouse models for retinal degeneration, in appreciation of the fact that degenerative diseases are very diverse and a single approach might not work for different conditions. For each model organism, I will test the effectiveness of rendering different cell types light sensitive with optogenetic tools. Examples include bipolar cells and subsets thereof, and ganglion cells. The optogenetic tools I will use include ChR2 which activates neurons upon light stimulation, and NpHR, which hyperpolarizes neurons.The success of vision restoration will be tested and quantified at many levels, starting from the cellular level in the retina, to verify proper expression of the neuromodulator, to the circuitry lev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unveiling the Roles of Chromatin Insulators in Higher-order Chromatin Architecture and Transcription Regulation one molecule at a time' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Eukaryotic chromosomes are condensed into several hierarchical levels of complexity: DNA is wrapped around core histones to form nucleosomes, nucleosomes form a higher-order structure called chromatin, and chromatin is subsequently organized by long-range contacts. The conformation of chromatin at these three levels greatly influences DNA transcription. One class of chromatin regulatory proteins called insulator factors set up boundaries between heterochromatin and euchromatin and generate long-range loops. In Drosophila, three types of insulators (Su(Hw), dCTCF and BEAF) have been shown to regulate transcription and organize chromatin at the higher level by the formation of long-range interactions that were proposed to be mediated by the coalescence of several insulator proteins into clusters (insulator bodies). Our research aims to unravel the mechanism by which insulator bodies dynamically regulate chromatin structure and transcription by using single-molecule biophysics and quantitative modeling. On one hand, we will apply novel super-resolution fluorescence microscopy methods to investigate the structure and assembly dynamics of insulator bodies in single cells throughout the cell cycle and the role of their regulatory partners. On the other hand, we will reconstitute the looping activity of insulators in vitro and apply single-molecule manipulation methods to gain detailed insights into the molecular mechanisms involved in defining and regulating chromatin organization by insulators. This project has the potential to impact our understanding of several fundamental cellular processes: transcription regulation, cell-cycle dynamics, higher-order chromatin organization, and cell differentiation. The methods developed here will be directly applicable to the investigati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Epigenetics and System Biology of Stem cells and Reprogramming'.

assistant: **Concept**

Chromatin is the basic regulatory unit of life, and as such it controls developmental and functional states of all cells, including pluripotency. In recent years methods to study chromatin and transcription have dramatically improved and expanded to genome-wide global approaches on the one hand, and single cell biology on the other, allowing systems-level understanding of epigenetic regulation of stem cells, reprogramming and development.The Epigenetics and Systems Biology of Stem Cells and Reprogramming Network (EpiSyStem) is comprised of 8 world renowned, ERC-granted researchers, 2 professional leading industrial partners and supported by 3 partner organizations and 3 international world acclaimed scientists as an advisory board, to provide a unique training environment. EpiSyStem combines chromatin biology in stem cells, early embryos and reprogramming, including the modelling of human neurological, chromatin-related diseases with bioinformatics, epigenetics/epigenomics, and systems biology at the population and single cell / single embryo level. This multidisciplinary approach will enable profound training and deep, systems-level understanding of chromatin biology and epigenetic regulation of stem cells, differentiation and reprogramming, with a strong support by industrial partners.The objectives of EpiSyStem is to create a European mesh in which 14 outstanding PhD students will be trained in fundamental questions of biological research, be exposed to the latest technologies and breakthroughs, supervised by leading experts with international contacts - with the aim to facilitate their path to future leadership with holistic view, coupled with the forefront of the current epigenetic research in the field. They will enjoy exchange programs, workshops on emerging topi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FPL 2004 enables easier participation of early stage researches via Ph.D. Forum and University Booth' in the context of a Sixth Framework call.

assistant: **Objectives**

The International Conference on Field-Programmable Logic and its Applications (FPL)" is the eldest and largest conference on all aspects of re-configurable computing. The aim of this conference is to bring together researchers from all over the world for a wide-ranging discussion of all forms of re-configurability and its applications. The conference is organised yearly in Europe and attended by 250 to 300 top-level scientists and researchers both from industry and academia and coming from different countries in Europe and the world. The objective of this LCF proposal is to ensure that young and starting researchers in the field of re-configurable systems benefit from the experience of leading researchers in this field. The proposal is aimed at supporting young and starting researchers for attending the conference. This will be done by(1) A substantially lower registration fee for students (50% of the regular registration fee).(2) The organisation of a PhD forum offering selected PhD students an opportunity to discuss their research project with leading scientists and researchers in the re-configurable systems community.(3) A travel and registration grant for all PhD students selected for the PhD forum.(4) A limited number of participation grants, covering travel and registration fees, for young researcher swishing to attend the conference. The proposed LCF project will help early-stage researchers to benefit from a world-class conference, to get exposure for their research project, and to interact and obtain feedback from scientific leaders in their field. The project will allow to maintain and grow this European event as the leading conference in the field of re-configurable computing and to give exposure to the strong European presence in this research field."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pyne - a pyrolysis network for Europe' in the context of a Fourth Framework call.

assistant: **Objectives**

The objective of this Concerted Action proposal is to develop and extend the very successful pyne Network that has been operational for two years, by widening the scope and including more industrially orientated activities. Until now this Network has promoted and aided the development of fast pyrolysis of biomass and wastes through dissemination of information on the technology and applications. This proposed development and expansion will build on the dissemination activities to date by additionally addressing known industrial concerns over implementation of fast pyrolysis and applications for the liquid product, and proactively encouraging their resolution by contributory and collaborative activities. From a European perspective the creation of a dedicated and focused international group who have the knowledge and expertise to provide strategic inputs to European policies is a considerable asset and this has already been useful employed in resolving strategic problems by the European Commission. The pyne Network has become established as the leading centre for information on fast pyrolysis of biomass and wastes through publication of a biannual newsletter with a circulation of over 2500 and a world wide distribution. While this is perhaps the most tangible outcome of the network, many other activities and deliverables have resulted including meetings, seminars, visits, conferences, scientist exchanges and reports all of which have served to greatly improve the knowledge base and expertise of the participants. It is through collaboration and interactions such as these that European industry can best benefit from the extensive R&D currently in progress in Europe by established research and commercial links to exploit the promise of this emerging technology. Fast pyrolys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Psychological Underpinnings of  Nonpharmaceutical Interventions' to be submitted under Horizon Europe.

assistant: **Abstract**

Infectious diseases cripple well-being, batter economies, and kill millions annually. These negative consequences can be drastically reduced via nonpharmaceutical interventions (NPIs)  behaviors that reduce the spread of pathogens. A wealth of recent theoretical and empirical work has illuminated how and why disgust intuitively motivates some NPIs, such as avoiding bodily wastes and spoiled foods. However, disgust does little to inhibit transmission via aerosols, respiratory droplets, and fomites  key pathways for the respiratory pathogens that circulate seasonally, have caused recent pandemics, and will cause the pandemics of the future. Hence, even with advances in our understanding of disgust, the psychological underpinnings of the less-intuitive NPIs that inhibit respiratory pathogens  such as handwashing, barriers to respiratory droplets and aerosols, and self-isolation while infectious  remain mysterious. This project addresses the urgent need to better understand these NPIs using theory and methods that cut across social psychology, evolutionary psychology, health psychology, and behavioral genetics. First, it catalogs and explains cross-cultural differences and similarities in NPI practices with an unprecedented survey of 50 nations, and it uses a state-of-the-art nuclear twin family design to assess within-population genetic and cultural transmission of NPIs. Second, it uses experimental methods to test the roles of folk theories of immunity, moralization, and conflicts between individual and collective interests on NPI practices. Third, it develops novel, theory-based interventions for increasing handwashing and voluntary quarantining while sick and uses objective assessments of soap use and total daily movements to evaluate those interventions. By providing g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reassessing Late Medieval Pharmacology: Logical and Metaphysical Tools in the Medical Context' (ReMedY) under Horizon Europe.

assistant: **Objectives**

ReMedY addresses the metaphysical, logical and epistemological implications of late medieval pharmacological classifications. Medieval pharmacology was often divided into a rational and a practical part. Rational pharmacology dealt with the theories of drug classification, explaining how to recognise the substance and the qualities of a drug and how to differentiate it from other drugs. Rational pharmacology was thoroughly re-systematised during the 14th century in various university milieus, having been influenced by scholastic philosophy. It is generally acknowledged that the faculty of medicine at Bologna played a central role in this process, due to its strong connection with the philosophical tradition. It is clear that some Bolognese masters were influenced by French modism, which based logic on ontology, dividing reality into the three 'modi' of being, knowledge and meaning. Yet, it has never been investigated how this philosophical debate has influenced rational pharmacology or how it has provided it with indispensable theoretical tools. And this is exactly where this project comes into the picture: ReMedYs unconventional and cross-disciplinary approach connects modist doctrines and pharmacological theories, providing an innovative interpretative key regarding the correlation between rational pharmacology and philosophy during the Middle Ages. The hypothesis of the project, namely that modist theories influenced a distinct tradition of late medieval rational pharmacology is entirely original. My team and I will link research fields that have been kept apart, but whose organic connections provide a new perspective on medieval philosophy. Combining philological, editorial, historical and epistemological approaches, the ReMedY team will deal with pharmacological te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Living in fragmented habitats: demographic causes and consequences of dispersal in the root vole Microtus oeconomus' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Within a fragmented population, dispersal affects the local demography of habitable patches, which in turn influences individual dispersal decisions. Despite growing interest in the demographic consequences or in the demographic causes of dispersal, a merging between these two aspects of the same problem is still awaited.   This project aims at developing a comprehensive view of the feedback loop between local demography and dispersal. We will use the root vole Microtus oeconomus as a model system to conduct both experimental and theoretical research on two crucial components of the feedback loop, namely the population age and sex structure.   In the experimental part of the project, we will set up two yearly experiments on the relationships between dispersal and local demography in patches contrasted by age structure (first experiment) or sex structure (second experiment). These manipulations will employ large fragmented landscapes maintained at the Evenstad Research Station (SE Norway) of the University of Oslo.   In the theoretical part of the project, we will develop and parameterise patch and stage specific population matrix models describing our experimental system. These models will help us to reconstruct patch dynamics during the breeding season and to obtain predictions on the inter-annual demography of our experimental landscapes. The relevance of our experimental and theoretical results will be highlighted by a broad review of the literature on the subject in vertebrates.   Our project will be networked with ecological centres working on dispersal and demography with different vertebrate models (University of Tromso, University of Aberdeen, University of Paris VI). This basic research could constitute a foundation for new conservation, management and harvesti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering Cis-Regulatory Principles of Transcriptional regulation:  Combining large-scale genetics and genomics to dissect functional principles of genome regulation during embryonic development' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding how genomic information is organised and interpreted to give rise to robust patterns of gene expression is a long-standing problem in genome biology, with direct implications for development, evolution and disease. Despite recent advances in locating regulatory elements in animal genomes, there is a general lack of functional data on elements in their endogenous setting – the bulk of our current knowledge comes from reporter assays examining elements out of context, giving insights on sufficiency but not necessity. The functional requirement of very few individual enhancers, and other elements, has been assessed by deletion, with even less known about how the action of multiple elements is integrated. To understand the functional effects of genetic variants, and how they are buffered during embryogenesis, it is imperative to genetically dissect regulatory domains to uncover functional rules of genome regulation within a well-characterised animal model. Here, by combining Drosophila population genetics, developmental genetics, and novel multiplexed genomic methods we will perform the first large-scale functional dissection of cis-regulatory landscapes during embryogenesis. Extensive resources make Drosophila a unique model organism for this task, including (a) 500 fully sequenced inbred wild isolates for population genetics, (b) over 20,000 fly strains custom-built for genome engineering & (c) a wealth of cis-regulatory information on the location of enhancers. The proposal has three Aims: 1) Use population genetics as a perturbation tool to functionally link regulatory elements to their target genes; 2) Systematically delete cis-regulatory elements to dissect their role in gene expression and genome topology; 3) Manipulate cis-regulatory domains to generat