RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protein Misfolding: Prion-like Propagation and Cure.  Implications for Neurodegenerative Diseases.' in the context of a Seventh Framework call.

assistant: **Objectives**

My long-term goal is to understand, how misfolded proteins, associated with the pathogenesis of most neurodegenerative diseases, propagate in a prion-like manner (i) and to identify strategies that could lead to cure protein misfolding (ii).(i) We have recently discovered that mutant SOD1 aggregates, associated with amyotrophic lateral sclerosis, penetrate inside cells and replicate their misfolded state indefinitely, just like prions. Using our robust cell-based system, we will identify the mechanisms underlying the prion-like propagation of misfolded proteins using unbiased biochemical approaches combined with siRNA screens (Aim 1).(ii) We have discovered a novel and selective way to rescue cells from protein misfolding stress. We have identified a small molecule, guanabenz, which binds to a regulatory subunit of protein phosphatase 1, PPP1R15A/GADD34, selectively disrupting the stress-induced dephosphorylation of the alpha subunit of translation initiation factor 2 (eIF2 alpha). Without affecting the related PPP1R15B-phosphatase complex and constitutive protein synthesis, guanabenz prolongs eIF2 alpha phosphorylation in stressed cells, thereby adjusting the protein production rates to levels manageable by available chaperones. This favors protein folding and thereby rescues cells from protein misfolding stress. This suggests that inhibition of PPP1R15A could ameliorate protein misfolding diseases. We will test this attractive possibility (Aim 2).Having provided the proof of principle that serine/threonine phosphatases are drug targets, we aim to investigate the detailed molecular mechanism by which guanabenz selectively inhibits PPP1R15A/GADD34, using a combination of biophysical and structural approaches (Aim 3). In addition, we will develop assays to identify other
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Insulin/IGF-1 Signaling Regulates Novel Activities of the ER Stress Response Gene ire-1' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The insulin/IGF-1 signaling pathway is a major conserved metabolic pathway that regulates aging and lifespan in worms, flies, and mammals. Using C.elegans as a model system, I discovered that ire-1, a highly conserved ER stress response gene, makes a big contribution to the longevity of animals with reduced insulin/IGF-1 signaling. I further discovered that inactivation of ire-1 results in a striking accumulation of DAF-28, an insulin-like peptide, in the body cavity of animals with reduced insulin/IGF1 signaling, but not in wild-type animals. ire-1’s most characterized mode of action is by activation of a downstream transcription factor XBP-1. A few recent studies have shown that ire-1 also has xbp-1 independent functions, however, these have not been characterized extensively. Interestingly, under conditions of reduced insulin/IGF-1 signaling, at least part of ire-1’s contribution to the extended lifespan is independent of xbp-1. Furthermore, the striking accumulation of the insulin-like peptide in the body cavity of animals with reduced insulin/IGF1 signaling is mediated by ire-1 completely independently of xbp-1. Thus, we identified novel xbp-1-independent activities of ire-1, which under conditions of reduced insulin/IGF-1 signaling alone, promote longevity and feedback to regulate insulin levels. I propose to combine molecular, genetic and biochemical approaches to further investigate the molecular mechanism that regulates the accumulation of the insulin/IGF-1 peptide, and investigate why this occurs specifically under conditions of reduced insulin/IGF-1 receptor signaling. These studies may be of particular importance and relevance in the context of diabetes, where insulin/IGF-1 signaling is dysfunctional, insulin levels are deregulated and insulin-secreting cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhanced energy and resource Efficiency and Performance in process industry Operations via onsite and cross-sectorial Symbiosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Out of the community created by SPIRE covering industrial and research actors throughout Europe, the EPOS project brings together 6 global process industries from 6 key relevant sectors: steel, cement, minerals, chemicals, bio-based/life science products and engineering. Together they represent 166 bn € in sales with 75% of their production located in Europe. The 6 industries joined forces with 2 excellent science institutes and 4 highly R&I minded SMEs, building the EPOS consortium with Ghent University as coordinator. With the aim of reinforcing competitiveness of the EU industry, it is the ambition of the EPOS partners to gain cross-sectorial knowledge and investigate cluster opportunities using an innovative Industrial Symbiosis (IS) platform to be developed and validated during the project. The main objective is to enable cross-sectorial IS and provide a wide range of technological and organisational options for making business and operations more efficient, more cost-effective, more competitive and more sustainable across process sectors. The expected impact is clearly in line with the SPIRE roadmap - and sector associations, city councils (in the districts where EPOS is deployed), the SPIRE PPP as well as standardisation bodies are committed to participate in the EPOS transdisciplinary advisory board. The EPOS project spans 48 months and its structure builds on activities that ensure the project challenge is addressed in an optimal way, including cross-sectorial key performance indicators, sector profiles and cross-sector markets, IS toolbox development, training and validation of the (simple and single) IS management tool in 5 clusters strategically located throughout EU (i.e. France, Poland, Switzerland and UK). Entire work packages are dedicated to disseminati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SAFER and TIMELY FLIGHTS with Automated Foreign Object Detection System', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The airport industry is a strategically important sector that makes a vital contribution to the EU's overall economy and employment by supporting 5 million jobs and contributing €300 billion to EU GDP. Despite the current economic crisis, global air transport is expected to grow by 5% annually till 2030 and airport operation companies are seeking methods to sustain FOD free runways for safer flights. Since, They generate costly breakdowns in planes, potential delays and cancellations, and eventually, also they are the cause of accidents and crashes. A-FOD is a FOD detection and management system comprised of a set of high resolution cameras connected to a AI system that is continuously trained by machine learning to solve the FODs detection problem. A-FOD is a complete FOD-hazard management system that allows airport maintenance teams to detect the smallest objects in any weather condition and also: 1) sends alerts to the operators; 2) provides live close-ups for a rapid visual verification without stopping the air traffic; 3) uses laser pointers and GPS to facilitate the removal and minimize its impact on the airport operation; 4) keeps records, in compliance with international regulations.A-FOD is successfully tested in an airport used for amateur flights and a demo will be done at one of busies airport of Turkey at May’17.  Airports will gain high advantages by being able to -decrease delay time by %90-reduce required repair cost of FOD hazards-realize significant cost savings-gaining more satisfied customers. The main objective of A-FOD project is to minimise and solve the problems caused by FOD in airports. With an affordable solution that integrates AI functionalities and an integrated FOD management system, we aim to gain a leading position on the EU market until
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'GlObal, Flexible, On-demand and Resourceful Timing IC & MEMS Encapsulated System' (Go4Time) targeting Seventh Framework.

assistant: **Abstract**

Go4Time will target the realization of a generic miniature timing module relying on the combination of an integrated circuit together with different MEMS resonators assembled hermetically in a single package. One of the main system feature is a temperature compensated low power real time clock mode with a power consumption below 1µW and a very tight frequency stability better than +-2ppm over an industrial temperature range. Owing to its combination with a higher frequency resonator and PLL techniques, the accurate reference is used to provide on-demand, a reconfigurable low jitter clock of high spectal purity at any frequency below 50MHz that could serve as a reference frequency for communication systems such as Bluetooth, GSM or wireless sensor networks.The project achievements will strengthen the global competitiveness of European industries in microsystems and smart miniaturised systems in the 3B$ timing market. The power aware scheme that is proposed will help meeting the green electronic challenge in consumer products and strengthen the competitiveness of the user industries by providing a generic solution with a much reduced bill of material.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Innovative offshore safety system to protect the body from cold shock in extreme conditions'.

assistant: **Innovation**

Every year 360,000 people die worldwide as a result of drowning, making it the third leading cause of unintentional injury death worldwide, accounting for 7% of all injury-related deaths. Globally, Immersion in cold water is the second most common cause of accidental death, at present 98 % of drowning deaths are caused by cold-water immersion., 3000 deaths. People working offshore who uses helicopters as their daily transportation faces the 80% risk of drowning when helicopter crashes or accidents occurs. As a matter of fact, air transportation is reported to be the leading cause of fatalities and accidents wherein 73 incidents were alone reported in UK  wherein cold-water drowning being the primary cause of death. This garment should allow buoyancy in water and protect from fire. Nevertheless, it currently has very little or no thermal property. For workers in cold waters, the law requires to wear 3 layers of clothing beneath the suit during winter and 2 layers during summer. Such under-suit clothing is inadequate for safety in case of contact with water (e.g. flight crash or simply a fall in the water).Iron Ocean proposes Centurion 3, the next-generation 3-layer upper body garment with integrated self-heating thermal gel system, specifically engineered to protect the upper body from cold shock. It can be comfortably worn under a safety suit to guarantee comfort and thermal protection in case of extreme environmental conditions. The clothing thermal properties are given by Iron Ocean’s engineered advanced thermo-chemical gel which actively produces heat upon contact with water. During the phase 1 feasibility study, Iron Ocean will establish a sound go-to-market strategy and supply chain, and will outline further development plans. In the second phase of the innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Finding new target to modulate food intake' (FEEDING).

assistant: **Concept**

Obesity is a major burden to public health as it increases the risk of several chronic diseases, like diabetes, cardiovascular diseases, musculoskeletal disorders or some cancers. Energy homeostasis is centrally regulated by the hypothalamus where the arcuate nucleus (ARC) orchestrates feeding behaviors and energy balance. Two neuronal populations of the ARC are considered as the first-order neurons mediating the effects of various signals such as leptin and insulin, the orexigenic neuropeptide (NP)Y/Agouti-related peptide (AgRP) neurons and the anorexigenic pro-opiomelanocortin (POMC)/Amphetamine-regulated transcript (CART) neurons. Leptin is an adipocyte-secreted peptidic hormone that inhibits food intake and regulates body weight. Nearly in all forms of obesity, circulating levels of leptin increase but fail to suppress food intake and body weight. This condition has been identified as ""leptin resistance"". G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and a notoriously successful source of drug targets. However, many GPCRs are understudied or even orphans meaning they have no known ligands. Despite our knowledge of the principal circuits regulating feeding, satiety, hunger and energy expenditure, we have been unable to deliver effective drugs targeting these systems. The failure in targeting the melanocortin pathways comes out partly from an incomplete understanding of leptin action, especially leptin resistance, at the central level. Here, we propose to investigate the interplay between the signaling of orphan GPCR and leptin receptor in leptin sensitive cells of the arcuate nucleus. To do so, we will use conditional knockout animals and pharmacological modulators. We will measure various metabolic parameters including weight and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Temporal Innovative Model for Imitative Network Generation: a framework to analyse temporal networks and generate surrogates' under Horizon Europe.

assistant: **Concept**

The TIMING project will develop a framework to analyse temporal networks and generate realistic surrogates. Observation of real-world temporal networks given as input will aim at grasping their intricate structure, resulting from temporal and topological causalities and correlations. I will devise a methodology to mimic these dynamics, using concepts of network science theory as guidelines. The generated synthetic networks will reproduce the fundamental features of the original topologies. This methodology will allow to obtain surrogate temporal networks to replace real data when the latter are not usable or sharable. This is particularly useful for social data, often subject to privacy issues. Moreover, since collected datasets are generally too small to observe interesting effects when simulating dynamical processes (a crucial problem, e.g., in computational epidemiology), it will serve as a tool for data augmentation. TIMING will in fact allow generating temporal networks with a higher number of nodes and a longer time span, based on original patterns extracted from smaller available datasets. TIMING will also provide the possibility to merge different original data, e.g., social interactions collected in different environments, providing a more realistic synthetic portrait of a society. Existing methods to generate realistic temporal graphs are scarce and are mainly based on blind reproduction of an original network, or they focus on specific theoretical aspects, while methods permitting an overall vision are missing. TIMING will fill this gap by combining an emulative algorithm with theoretical inductions, taking into account the mesoscale interplay between time and topology. I will develop the project in the team of Prof. Alain Barrat at CNRS (France), working at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tracing novel androgen pathways: deciphering the role of 16α-hydroxylation in human fetal biology' (SHOXY).

assistant: **Concept**

Steroid hormones, produced by the fetal adrenal, are metabolised by the fetal liver and placenta thereby regulating fetal development. Consequently, these steroids are also implicated in endocrine-related disorders and diseases that present in the fetal and neonatal stage. The major fetal liver cytochrome P450 enzyme, CYP3A7, catalyses the production of 16α-hydroxy-dehydroepiandrosterone (16α-hydroxy DHEA) leading to the biosynthesis of the 16α-hydroxy estrogen of pregnancy, estriol, in the placenta. This 16α-hydroxylation is also mediated by CYP3A4 in neonates, as a switch from the predominant CYP3A7 to CYP3A4 expression occurs after birth. Both enzymes, together with CYP3A5 (expressed in adult livers) are capable of hydroxylating steroid substrates on C16 producing metabolites in the fetal and neonatal stages. Importantly, the major adrenal steroid, 11β-hydroxyandrostenedione (11OHA4), a C11-oxy androgen, is produced in the fetal adrenals and circulatory levels have been quantified at birth. The chemical structure of 11OHA4, possessing no moiety on C16, allows it to be hydroxylated by CYP3A enzymes —producing novel downstream 16α-hydroxylated metabolites. While the contribution of 16α-hydroxy DHEA to fetal biology has been widely reported, the contribution of 16α-hydroxy C11-oxy androgens has not, to date, been characterised. Moreover, these metabolites have not been structurally identified. I hypothesise that C11-oxy androgens are catalysed by CYP3As, producing novel 16α-hydroxy C11-oxy androgens in the liver and the placenta. State-of-the-art high-resolution mass spectrometry platforms will be utilised to identify these novel metabolites and confirm the hypothesis. Significance of the proposed study: This project will advance our current knowledge on the downstream
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional/Harmonic Analysis of Covariant Transforms' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The topic of this proposal is a structured extension of abstract harmonic analysis and covariant/contravariant transforms over homogeneous spaces of locally compact groups. We are going to develop a systematic framework to study the structure and properties of convolution-type operators associated to locally compact groups, both from a theoretical perspective and in application to geometric analysis, operator theory and mathematical physics.The first objective is to present the abstract notion of relative dual space for homogeneous spaces. Then we present the theory of relative Fourier analysis over these homogeneous spaces by applying the the abstract theory of relative dual space. Finally, we explore a general model of covariant/contravariant analysis over homogeneous spaces. The entire project will be an important contribution to the field of abstract harmonic analysis, harmonic analysis, geometric analysis andtheoretical physics, presenting a unified perspective on the structure of these homogeneous spaces. Applications to symbolic calculus of operators and quantum information theory will be explored.The Fellow will gain new skills and experience in applications of his knowledge in mathematical physics and other areas. Progress in this ambitious project will reinforce Fellow's reputation and support him in obtaining a strong academic position. The host will gain from Fellow's expertise, on the representation theory/abstract harmonic analysis border, which Fellow has developed from his tree-year PostDoc in Vienna--the one of world's leading wavelets groups.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nir-measurement-technique of norganic-concentration in agriculture-soils' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The objective of the project is to develop a NIR measurement-technique for the economical and scientific use in agriculture. The background is the necessity to measure the total effective and available Inorganic, the residue of Unfertilised and C/N-proportions in soils, peat and composts on plant-fields and plantations in order to get a fast, cheap and complete overview about the soil situation regarding the nitrogen content. This is not possible when using only wet-chemical analytics. The non-controlled use of fertiliser in the cultivating of food-plant affects not only the health of human life when involving high concentrations of nitrogen in toad-chain and ground water, but also fauna and flora in rivers and lakes. The project combines the economic advantages for farmers to ecological ones, for e.g. for nature sanctuaries and polluted lakes and rivers.