RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The origin and impact of impaired ubiquitin signaling in the degeneration of neurons' to be submitted under Horizon Europe.

assistant: **Abstract**

Neurodegenerative diseases share similar hallmarks such as protein aggregation, suggesting that impaired protein degradation may be a common denominator. The major cellular pathways mediating protein degradation are the Ubiquitin-proteasome system (UPS) and autophagy, both regulated by ubiquitin signaling. However, aside from specific mutations in familial neurodegeneration cases, an early cause for failing ubiquitin-dependent proteolysis remains unclear. This proposal will test our unconventional hypothesis that dysregulated ubiquitin signaling is an early event in mechanisms of neurodegeneration, linking together numerous disease hallmarks. Towards this goal, we present groundbreaking findings that a mutated UPS protein resulting from a non-heritable transcription frameshift and present in the brains of neurodegenerative patients, particularly Alzheimer's disease (AD), is sufficient to trigger disease hallmarks in 3-D human neuronal cultures. This unique set-up replicates the main pathological hallmarks of AD without relying on any of the known genetic causes or risk factors. Utilizing this novel model, we have identified a previously unknown enzyme active site in a key neuroprotective protein, which now allows us to study the role of ubiquitin signaling in disease pathology.Specifically, this proposal seeks to understand both the source of disease-related ubiquitin signaling deterioration and its impact on neurons, by:1)Studying the mechanisms that trigger disruption of ubiquitin signaling in neurons.2)Understanding the consequences of altered ubiquitin signaling in human neuronal models of AD.3)Searching for mechanisms of neuroprotection mediated by key enzymes of the UPS. The outcome will develop new models of neurodegeneration, improve methods to study ubiquitin s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards an operational prediction system for the north atlantic and european coastal zones' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The objective of TOPAZ is to implement a preoperational monitoring and forecasting system for the North Atlantic, the Nordic Seas and the Arctic. The system will use a state of the art coupled ocean circulation and marine ecosystern model and assimilate observations available in near real time from satellites and in site observation programs. Sophisticated data assimilation methods will be used to assimilate the observations. Regional models will be nested into the large scale Atlantic model, to properly resolve the processes in the European coastal zone. Unique is the use of a single model by all participants I which ensure a focus on system development. Further, during a real time operation experiment the system will be used to predict mesoscale currents in support of offshore deep-water oil Production to market the TOPAZ system to an identified user group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Researchers' Night in Wielkopolska' (POZNIGHT).

assistant: **Concept**

The POZNIGHT project is the continuation of the Researchers’ Night projects of the past two years. Both Researchers’ Night projects of the year 2007 and 2008 were highly successful. The Researchers’ Night has become an important element of promoting Poznan researchers’ image. The POZNIGHT project sets new objectives. - The participation of children and young people from the rural areas of Wielkopolska region - thus those who do not have every day contact with researchers or universities. - the participation in the project of four great academic centres - the estimated participation of over 40 thousand people in the Researchers’ Night 2009 Until now the citizens of Poznan and its suburbs are those who visited the Researchers’ Night. The research on the impact of the Researchers’ Night on the scientist’s image has shown that the public from Poznan is highly interested in this subject and gradually changes its opinion on researchers, precisely under the influence of this event. Introducing the idea of the Researchers’ Night in the country will surely result in greater fascination for popular science and scientific problems. The Researchers’ Night is a recognisable brand. The year by year growing participation in the event shows that sightseeing and playing scientist at night is interesting. Therefore the organisers have increased the number of project partners and places destined to science games. Three main universities of Wielkopolska region, as well as the greatest education and research centre for Computing Science in Poland, will take part in the 2009 project. The development of the information campaign and the logistics of the event according to the plans will result in the participation of approximately 40 thousand people in the Researchers’ Night 2009 in Poznan. As
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unveiling the functional outcome of single nucleotide polymorphisms and variants in oligodendroglia in multiple sclerosis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Multiple sclerosis (MS) is a neurological disease characterized by autoimmune attack targeting oligodendroglia (OLG) in the central nervous system (CNS), and in particular their myelin, which ensheaths neuronal axons. Genome-wide association studies (GWAS) have led to the identification of hundreds of single-nucleotide polymorphisms (SNPs) and variants that are associated with MS risk. Many of these are located near genes associated with immune cells, indicating a key role for these cells in MS. Using single-cell omics approaches, we recently found that OLG present chromatin accessibility or express genes associated with some of these SNPs/variants, both in health and disease. Here, we hypothesize that OLG have a more active role in MS than previously anticipated, and therefore we will determine the function of MS SNPs/variants in OLG in the context of MS, using humanized mouse models, patient samples and new single-cell omics techniques recently developed in my group. We will 1) characterize in-depth the transcriptomic and epigenomic landscape of human and mouse OLG in the context of MS, to identify putative genes affected by the SNPs/variants; 2) perform CRISPR-guided editing of a cohort of the identified SNPs/variants in human OLG, and determine the consequences of the editing at a) an epigenomic and transcriptional level, linking specific SNPs/variants to their bona-fide target genes, and b) a functional level, by performing an array of functional assays targeting myelination, cell survival, and immune function, both in vitro and in humanized mouse chimeras in which engineered human OLG have been transplanted. We will use single-cell and spatial omics technologies, such as nanoCUT&Tag and spatial CUT&Tag, among others which we have recently developed in my research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Infrastructure for Analysis and Experimentation on Ecosystems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

ANAEE will provide Europe with a distributed and coordinated set of experimental, analytical and modelling platforms to analyse and predict in a precise manner the response of the main continental ecosystems to environmental and land use changes. ANAEE will consist of highly equipped in natura and in vitro experimental platforms associated with sophisticated analytical and modelling platforms coupled to networks of instrumented observation and monitoring sites throughout Europe.ANAEE will bring together, for the first time, the major experimental, analytical and modelling facilities in ecosystem science, agriculture and forestry in Europe. In uniting under the same umbrella and with a common vision these highly instrumented ecosystem research facilities, ANAEE will be a key instrument in both structuring and improving the European Research Area in this field. ANAEE will be the reference point for rigorously assessing ecosystem services and their responses to management by agriculture, forestry and to global change. In the context of the development of European bio-economy, critical political, environmental and scientific questions related to ecosystems functioning and services will be answered. ANAEE will therefore be a key instrument for the implementation of forthcoming national and joint programming initiatives notably the JPI “Agriculture, Food Security and Climate Change” (FACCE-JPI).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Origins of the Molecular Cloud Structure'.

assistant: **Objectives**

Understanding the physical processes that control the life-cycle of the interstellar medium (ISM) is one of the key themes in the astrophysics of galaxies today. This importance originates from the role of the ISM as the birthplace of new stars, and therefore, as an indivisible component of galaxy evolution. Exactly how the conversion of the ISM to stars takes place is intricately linked to how the internal structure of the cold, molecular clouds in the ISM forms and evolves. Despite this pivotal role, our picture of the molecular cloud structure has a fundamental lacking: it is based largely on observations of low-mass molecular clouds. Yet, it is the massive, giant molecular clouds (GMCs) in which most stars form and which impact the ISM of galaxies most. I present a program that will fill this gap and make profound progress in the field. We have developed a new observational technique that provides an unparalleled view of the structure of young GMCs. I also have developed a powerful tool to study the most important structural characteristics of molecular clouds, e.g., the probability distribution of volume densities, which have not been accessible before. With this program, the full potential of these tools will be put into use. We will produce a unique, high-fidelity column density data set for a statistically interesting volume in the Galaxy, including thousands of molecular clouds. The data set will be unmatched in its quality and extent, providing an unprecedented basis for statistical studies. We will then connect this outstanding observational view with state-of-the-art numerical simulations. This approach allows us to address the key question in the field: Which processes drive the structure formation in massive molecular clouds, and how do they do it? Most cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Robust and Energy-Efficient Numerical Solvers Towards Reliable and Sustainable Scientific Computations' (Robust) under Horizon 2020.

assistant: **Objectives**

Computations in parallel environments, like the emerging Exascale systems, are usually orchestrated by complex runtimes that employ various strategies to uniformly and efficiently distribute computations and data. However, these strategies, pursuing excellent performance scalability, may also impair numerical reliability (accuracy and reproducibility) of final results due to the dynamic and, thus, non-deterministic execution as well as non-associativity of floating-point operations. Additionally, scientific computations frequently rely upon only one working precision for computing problems with various complexities, which leads to the significant underutilization of the floating-point representation or the lack of accuracy. The Robust project aims to address the issue of reliable and sustainable scientific computations through developing robust, energy-efficient, and high performing algorithmic solutions for underlying numerical linear algebra solvers and libraries as well as applying these solutions in applications and kernels at scale.  The fellow, Roman Iakymchuk, is an expert in numerical linear algebra and high-performance computing and will collaborate with the research team of Prof. Stef Graillat at the Sorbonne University, who are experts in numerical analysis and computer arithmetic. This unique collaboration and combination of skill sets are crucial to embed numerical reliability and sustainability in algorithmic solutions for linear algebra operations and solvers. The derivation of novel robust algorithmic solutions, which will lead to either faster or more energy-efficient execution, will also grant a user an opportunity to specify the expected output accuracy of computations while ensuring optimal intermediate precisions. This ambitious research project in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Smart signaling system to increase road safety' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Walking is 36 times more dangerous than driving, and 300 times more dangerous than flying. The first road crossing was invented in the 1930’s and remain almost the same since then.  Each year road crashes generates around 95,000 fatalities and 2.4 million injuries only in EU region. 90 % of crashes are linked to human error, with pedestrians and riders constituting the main victims (39% of all deaths in road crashes) due to primarily inadequate visibility of pedestrians and vehicle speed.  The problem remains unsolved due the limitations of current signs and warning technologies, such as: Ineffectiveness over time due to the temporary tunnel vision issue; Low tolerance to extreme weather conditions;  Lack of incorporated Intelligent Transport Systems (ITS). Many of current signaling systems deform road surface/bent the sidewalks after continuous vehicle transit over them or require complex maintenance operations with high return on investment.In response to these challenges, Innvoaciones SP3 is bringing Sislum to the market: an emerging lighting system to increase road safety; promoting “smart mobility” through maximum crosswalk visibility and becoming a key enabler device to reduce road accidents up to 70%. According the audit performed by a certified authority, due to its potential impact in accident reduction, Sislum is recommend being installed in areas with more vulnerable users, such as in schools’ areas, pedestrian crossings, level crossings, bike paths, bus stops, parking exits, airports, and police stations among others.Sislum has already been tested in different road sections in 3 municipalities in Spain, including testing for analytics of the data generated by the application, with a positive outcome of increasing visibility up to 800m.Our goal is to reach th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Aerosol and Cloud Influence on global surface UV irradiance retrieved from satellite sensors' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Ultraviolet (UV) solar radiation has a broad range of effects concerning life on Earth. It influences not only human beings, but also plants and animals. Furthermore, it causes degradation of materials and functions as a driver of atmospheric chemistry. In order to study the UV related effects and their implications thoroughly; accurate information is needed on UV radiation intensities over the globe. The main overall scientific goal of this project is to search for improvements in estimating surface UV from satellite measurements (AURA/OMI, EUMETSAT/O3MSAF) and thus to decrease the uncertainty related to the globally available surface UV data, which is of importance and interest for a wide discipline of UV related studies. The above goal is planned to be achieved through the integration of measurements from different satellite sensors, which is likely the most feasible strategy for improving on the uncertainties related to UV radiation data. Major step of the project is to link aerosol and cloud retrievals from various (mainly A-Train) satellite sensors and also global scale modeling initiatives (AeroCom) with solar UV satellite retrievals, through the quantification of their effects on solar radiation reaching the earth’s surface. In addition, to increase the UV data end users, with emphasis on the Atmospheric chemistry research community introducing global products of photolysis frequencies of O¬zone and NO2. Using UV irradiance satellite/products, a modified method will be proposed for the retrieval of such parameters in a global scale. All, results will be validated against available quality assured ground-based measurements. Through this project the applicant aims to transfer the substantial experience in satellite-based instruments, global monitoring of atmospher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimising Robot Performance while Dreaming' to be submitted under Horizon 2020.

assistant: **Abstract**

Sleep! For hominids and most other mammals sleep means more than regeneration. Sleep positively affects working memory, which in turn improves higher-level cognitive functions such as decision making and reasoning. This is the inspiration of RobDREAM! What if robots could also improve their capabilities in their inactive phases – by processing experiences made during the working day and by exploring – or “dreaming” of – possible future situations and how to solve them best?    In RobDREAM we will improve industrial mobile manipulators’ perception, navigation and manipulation and grasping capabilities by automatic optimization of parameters, strategies and selection of tools within a portfolio of key algorithms for perception, navigation and manipulation and grasping, by means of learning and simulation, and through use case driven evaluation. As a result, mobile manipulation systems will adapt more quickly to new tasks, jobs, parts, areas of operation and various other constraints. From a scientific perspective the RobDREAM robots will feature increased adaptability, dependability, flexibility, configurability, decisional autonomy, as well as improved abilities in perception, interaction manipulation and motion. The technology readiness level (TRL) of the related key technologies will be increased by means of frequent and iterative real-world testing, validation and improvement phases from the very beginning of the project.From an economic perspective the Quality of Service and the Overall Equipment Efficiency will increase, while at the same time the Total Cost of Ownership for setup, programming and parameter tuning will decrease. These advantages will support the competitiveness of Europe's manufacturing sector, in particular in SME-like settings with higher product