RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'X-Ray Fluorescence, Shape recognition & Machine Learning for Efficient and Economic Recycling of Mixed Metals from Co-mingled Waste.' under Horizon 2020.

assistant: **Concept**

Recycling is a key battleground in combating climate change. By reducing the volume of materials that need to be removed from the ground and then processed significant emissions reductions can be achieved. Metals such as Copper, Tin, Aluminium, Gold, Silver and Zinc are infinitely recyclable if properly separated and are key elements in the global economy. Currently these metals cannot be economically recovered from mixed recycling as most recyclers do not have a sustainable solution for separation and recovery of these valuable resources. Therefore, these mixed metals currently either end up being exported to be manually sorted, sent to landfill or lost in the sorting process.As a result, recycling rates for these crucial materials are far lower than they need to be if the EU is to meet its recycling targets and kickstart the circular economy. The OMR project will create a unique combination of X-Ray Fluorescence (XRF), shape recognition and Machine Learning (ML) techniques to enable efficient and economic recycling of mixed non-ferrous metals from co-mingled waste. This will turn a low value feedstock into several high value output streams which will further increase the advantages of co-mingled collection and allow it to be rapidly rolled out across the EU to help meet the EU’s ambitious 65% recycling target.Furthermore the project will deliver a sustainable market for mixed metals, provide aerospace and automotive manufacturers with a new source of guaranteed quality non-ferrous metals, divert material from landfill, preserve natural resources, increase recycling rates and create employment opportunities as new facilities are rolled out across the EU. Recresco aim to operate 3 new sorting facilities by year 4 post project, generating €12.1m in additional turnover an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Harnessing Granzyme Pathways: Developing Novel Antimicrobial Therapies Against Resistant Bacterial Strains.' (MicroGRANZ).

assistant: **Concept**

Antimicrobial resistance (AMR) is a critical global health threat, causing over 4.3 million infections annually in OECD countries, with 1.7 million in the EU/EEA. AMR leads to higher mortality, while the economic impact is severe, with increased healthcare costs due to prolonged hospital stays and the need for more expensive treatments, affecting both productivity and societal well-being.MicroGRANZ seeks to explore the antibacterial potential of granzyme proteins—Granzyme A, Granzyme B, and Granzyme M—as novel therapeutic agents to combat antibiotic-resistant bacteria. Granzymes, produced by cytotoxic T lymphocytes and natural killer cells, assist immune cells in pathogen clearance, but also kill extracellular bacteria directly. Granzymes offer great potential as an alternative to antibiotics; however, their mode of action is not well understood.In MicroGRANZ I will employ interdisciplinary approaches including live-cell microscopy and robotic liquid handling, where thousands of bacteria together with host cells can be monitored over time. This will provide a new understanding of granzyme’s specificity for different bacteria, and in combination with immune cells for cell-assisted killing. I will also improve their effectives by combining different granzymes together, also with other host molecules like Granulysin and Perforin, which enable them to get inside cells. Finally, I will use nanomaterials for enhanced and targeted delivery and controlled release into cells.By investigating how granzyme proteins can be used to tackle resistant bacteria, MicroGRANZ aims to develop innovative immunotherapies that address the global challenge of AMR. The outcomes could pave the way for new treatments that strengthen the innate immune response, aligning with international public he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Architecture for Scalable, Self-*, human-centric, Intelligent, Secure, and Tactile next generation IoT' (ASSIST-IoT).

assistant: **Innovation**

ASSIST-IoT will provide an innovative reference architecture, envisioned as a decentralized ecosystem, where intelligence is distributed among nodes by implementing AI/ML close to data generation and actuation, and hyperconnecting nodes, in the edge-cloud continuum, over softwarized smart network. Smart network will be realised by means of virtualized functions, with clear separation of control and data planes, facilitating efficient infrastructure programmability. Moreover, the action will follow a DevSecOps methodology to ensure the integration of security, privacy, and trust, by design, in all aspects of the envisioned ecosystems.ASSIST-IoT will be supported by several pillars: (i) innovative IoT architecture, to adapt to the NGI paradigm, with three-dimensional approach, including intelligence, security and privacy by design, supporting decentralized collaborative decision-making; (ii) moving from semantic interoperability to semantically-enabled cross-platform, cross-domain data transactions, within decentralized governance, DLT-anchoring transaction security, privacy and trust; (iii) development and integration of innovative devices, supporting context-aware computing, to enable effective decision making close to events; (iv) introduction of self-* mechanisms, supporting self-awareness and (semi-)autonomous behaviours across IoT deployments, and (v) Tactile Internet support for latency applications, like AR/VR/MR, and human-centric interaction with IoT components. Results of the action will provide foundation for a comprehensive practice-based methodology, for future designers and implementers of smart IoT ecosystems.Finally, to validate research results, and developed solutions, and to ensure their wide applicability, extended pilot deployments with strong end-us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the role of GPCR expression diversity in receptor physiology and drug response' under Horizon 2020.

assistant: **Concept**

G protein coupled receptors (GPCRs) are key regulators of cell homeostasis. Given their importance in cell physiology, they have been extensively exploited as drug targets. Despite this, many discordant observations on receptor signalling and on GPCR drug response remain unexplained. Changes in receptor expression in different human tissues can be a key contributor to such differences in GPCR behaviour. And still, no comprehensive study has characterized human GPCR transcriptomics and its impact on receptor function. Such an analysis could help answer fundamental questions on GPCR pharmacology such as: How are different receptor types distributed across human tissues and how does this affect receptor function? How does age and gender-related GPCR differential expression affect receptor pharmacology? And how does splice variant distribution in different tissues influence receptor signalling? In this project, I will address these questions by applying a computational biology approach combining publicly available transcriptomics data with information on receptor structure, intracellular coupling, and pharmacogenomics. This will allow obtaining for the first time a GPCR-wide distribution map across human tissues; determining how differential expression according to age and gender can affect GPCR function; and assessing the impact of alternative splicing on receptor integrity, regulation, and coupling. At the end of this project, these insights will be made publicly available to the research community through the development of a web resource associated with the widely-used GPCR database. Using such a multidisciplinary approach, the proposed analysis will help clarify the importance of different receptor transcriptional profiles in cell physiology and drug response, point to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Conformal structures and dynamics' (CODY) under Sixth Framework.

assistant: **Objectives**

The research aim of the proposed training network: Conformal structures and dynamics" is to understand local self-similar structure of fractal spaces, objects or processes, by methods of space-time conformal rescaling. This key area is on the interface of three research disciplines. The proposed network consists of 9 teams, with some of Europe's best mathematicians participating. The network aims to offer 240 person/month appointments for ESR's and 180 person/ month appointments for ER's. Through innovative boundary-crossing training, the network will overcome the present fragmentation and integrate these disciplines."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Skill development and firm upgrading to sustain the competitiveness of the EU manufacturing sector' (SkillUp) under Horizon 2020.

assistant: **Objectives**

In the last decades, European manufacturing has been the object of an intense reorganisation driven crucially by multinational firms’ offshoring strategies that have led to the emergence of global production networks. European companies have mainly devoted their efforts to presiding over high value-added upstream and downstream activities whilst offshoring low value-added operations to low labour cost economies. The hollowing out of manufacturing activities is impacting on the EU labour market: it affects the demand of jobs in the EU, and the local and regional stock of competences, raising concerns over a mismatch between firms’ skill needs and persistent skill shortages. The aim of SkillUp is to explore routes that combine firms’ upgrading strategies with workforce skill development in order to enhance the competitiveness of EU manufacturing industries. SkillUp focuses on: 1) which skills are needed for the jobs of today and tomorrow: in which industries? in which regions? 2) are these skills available and where can they be found? and 3) how should such skills be created and what training/education needs to be put in place for this be achieved? Long term European socio-economic growth rests of maintaining a competitive manufacturing sector necessarily in high value added industries, and SkillUp will identify the appropriate sets of skills needed to meet firms’ demand and enhance EU manufacturing competitiveness.  The study will use a mixed method research: 1) inferential statistics (t-test) on the EU labour participation using EU Labour Force Survey; 2) a multiple case-study approach by collecting primary through firm-based interviews and secondary data from company reports as well as industry and regional aggregate data from Eurostat and the Labour Force Survey; 3) F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovation in hortofruticultural products - innovative practices and technology transfer in the chain of fresh and minimally processed fruits and vegetables', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The purpose of this THEMATIC NETWORK is to set up an efficient across-Europe collaboration between producers, technologists, retailers and other relevant experts able to boost technology transfer (and Rmethodology transfer') related to innovative solutions for offering high quality convenience products at the point of sale. The development of the market potential of fruits and vegetables is limited by the offer of quality, safe, convenience products. While sensory attributes are important, convenience of use is also a need for today's consumers and fresh fruits and vegetables are generally time consuming to prepare. Furthermore, fruits and vegetables offer innovative product opportunities in the so-called 'future foods', that is, minimally processed fruits and vegetables with prominent 'natural' and 'healthyr features (anti-cancer, health-drinks, fermented bio-active vegetable preparations, etc.).  The project therefore intends to explore the good opportunity for transeuropean collaboration in the development of the market potential of fruits and vegetables: technology transfer (occurring largely from North to South) can improve the offer of hortofruticultural products (moving more from South to North) at adequate prices, good quality and increased convenience. This translates into benefits to the healthy eating habits of the (specially northern) consumers and added value to the (particularly southem) producers.  The purpose of such collaboration is to try to promote more 'process' innovation (specially in the South) and 'product' innovation (specially in the North).  The tasks defined are the following: 1. Analysis of the supply and distribution chain of fresh and minimally processed hortofruticultural products in different countries of Northern and Southern Europe; a)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Connecting advisOrs towaRd a European NETwork for consumer-producer chains' (COREnet).

assistant: **Concept**

Short Food Supply Chains (SFSCs) or producer-consumer chains are supply chains involving a limited number of intermediaries between farmers and consumers, who are committed to cooperation, local economic development, and maintaining close geographical and social relations. In rebuilding post-Covid, SFSCs are being promoted by governments, civil society and consumer groups in many EU member states as a means for building more inclusive, resilient and sustainable food systems. But SFSC initiators, participants and promoters are confronted by a fragmented knowledge landscape, coupled with a lack of clarity as to essential skills and competencies in all phases from farm to fork. The COREnet project proposes to respond by supporting the systematic development of more effective SFSC advising, based on bringing together public, private and civic advisors through IT-enabled peer-to-peer learning and mutual support. This approach requires interacting with advisors, farmers, consumers and a more holistic approach aimed at helping SFSCs achieve not just a bigger market share, but a greener market impact. Project activities are concerned with (1) developing SFSC advisory capabilities based on a knowledge mapping and on-line listing of SFSC advisors from all EU27 in ways that enable the sharing and exchange of cost-effective practice solutions that improve SFSC social, economic and environmental performance and increase their impact in the food value chain; (2) preparing learning resources in the form of a network of 30 Golden Cases (exemplars of SFSC models that have achieved business success) and initiating 27 Lighthouse Projects (initiatives using Golden cases to introduce advisory services for improving SFSC performance with at least one in each of the EU-27); (3) establishing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Host Response to Baculovirus infection in Helicoverpa armigera' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Baculoviruses are large, double-stranded DNA viruses infecting invertebrates, mostly insects from the family Lepidoptera. They cause epizootics in pest insects and thus are regarded as promising alternatives for hazardous chemical insecticides.The application of baculoviruses; however has not yet met its potential mainly due to their relatively slow speed of action and narrow spectrum of action. Different approaches are currently undertaken to improve baculovirus pathogenicity, i.e. chemical or biological additives, genetic modifications.In contrast to previous studies focused on understanding the role of the viral genes in the infection, the main objective of the proposed project is to identify and characterise insect genes involved in the response to baculovirus infection in the mid-gut of Helicoverpa armigera.Studies will be focused on the host defence mechanisms occurring in the mid-gut cells during the first step of the infection (primary infection), which is a determinant of the successful infection. Suppression subtractive hybridisation (SSH) and Quantitative-PCR technologies will be used for the selection of mid-gut genes that are regulated in the host response.Relevant genes will be characterized and recombinant baculoviruses altering the express ion of those genes will be constructed in order to determine their role in the infection process.Recombinant baculoviruses will be also evaluated in terms of dose and time to kill. Results from proposed project will be useful for a better understanding of the insect-pathogen interactions and could be interesting for the design of new baculovirus with higher speed of action and/or broader host range.Additionally, identification of genes involved in response to baculovirus could target genes candidate to be responsible f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'How dividing cells adapt to karyotypic evolution' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Alterations in chromosome number and size are hallmarks of cancer, and yet they are also crucial for species evolution. Recent insight on chromosome structure and segregation, together with significant advances in genomic sequencing, established previously underappreciated parallels between the mechanisms of karyotypic evolution during speciation and cancer. Importantly, alterations in chromosome number and size pose significant challenges for the cell division machinery. However, how dividing cells adapt to cope with karyotypic alterations remains an outstanding fundamental question with strong clinical implications. To address this, we propose an innovative approach that integrates super-resolution microscopy, large-scale 3D cryo-electron tomography reconstructions, computational modelling and cell fusion experiments in Indian and Chinese muntjacs, two closely related deer species with identical genomes, but extremely divergent chromosome number (2n=6/7 vs. 2n=46, respectively) and size. We will focus on dissecting mechanistic aspects underlying mitotic spindle organization, chromosome dynamics, checkpoint control of mitotic progression and segregation fidelity in both muntjac species, with the goal of identifying genes differentially required for efficient mitosis in cells with karyotypic alterations. In parallel, we will exploit functional genomics in Cervidae, including telomere-to-telomere sequencing of Indian and Chinese muntjac genomes, to determine and manipulate the exact chromosome fusion sites between both species, while testing the novel hypothesis of a viral mechanism in the evolution of their karyotypes. Lastly, to test the limits of karyotypic evolution for chromosome segregation, we will engineer mammalian cells with only 1 or 2 chromosomes and investig