RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultrafast Hyperpolarized NMR and MRI in Multiple Dimensions' under Seventh Framework.

assistant: **Concept**

Multidimensional nuclear magnetic resonance (nD NMR) plays a unique role in Science as a primary tool for the characterization of biomolecules, as part of drug-discovery processes, and in clinical imaging (MRI). Further progress in NMR is hampered by this spectroscopy s low sensitivity, arising from the weak interactions that it involves. The prospects of solving this problem by continuing with incremental bigger machines approaches are poor, given the high maturity reached by existing technologies. The present Project deals with this issue by departing from traditional concepts, and relying on two incipient but highly promising developments in the field. One of these pertains ex situ dynamic nuclear hyperpolarization, an approach capable of eliciting liquid state NMR signals that surpass those afforded by the highest-field spectrometers by factors e10,000. While capable of providing super-signals hyperpolarization has the drawback of involving irreversible changes in the physical state of the sample. This makes it incompatible with nD NMR technologies, requiring the collection of multiple scans identical to one another except for systematic delay variations. As second component in this high-risk/high-gain Project we propose merging hyperpolarization with ultrafast" methods that we have recently developed for completing arbitrary nD NMR/MRI acquisitions within a single scan. The resulting synergy could increase sensitivity by orders of magnitude, while demanding negligibly small amounts of spectrometer/scanner time to complete nD acquisitions. This should provide an ideal starting point for the analysis of a variety of organic and structural biology problems, and provide new tools to explore in vivo metabolism focusing on cancer biomarkers."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Generate Renewable Energy Efficiently using Nanofabricated Silicon'.

assistant: **Concept**

The primary objective of this project is to demonstrate integrated on-chip thermoelectric energy harvesting using micro-/nano-fabricated Si/SiGe nanostructures with improved efficiencies through the use of band-structure and phonon engineering. High performance thermoelectric materials require high electrical conductivity and low thermal conductivity. Our approach is to engineer thermoelectric materials which enhance the electrical conductivity while simultaneously blocking the tranport of thermal energy through the devices. Bulk 2D Si/SiGe superlattices, laterally patterned 1D nanowires and 0D quantum dots made from Si/SiGe heterostructure technology will be investigated for high performance thermoelectrics in microsystems and other applications. We propose to combine the optimum 2D superlattice or 0D quantum dot material with 1D nanowire patterning to further improve the thermoelectric performance of microgenerators. The final optimised thermoelectric generator will be integrated with a capacitor energy store on a mm-sized single silicon chip to demonstrate a power source for an autonomous system. This will be used to power a micropower CMOS sensor to demonstrate its use as an energy harvesting system. The developed technology will be compatible with the power supply requirements for wireless autonomous systems such as those defined in the IEEE 802.15.4 standard. While the project is aimed at on-chip sustainable energy generation, the techniques, technology and IP being developed will also be able to be deployed into high efficiency (>20%) thermoelectric generators and Peltier coolers for domestic and industrial applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An integrated study on three novel regulatory hubs in megakaryocytes and platelets, discovered as risk genes for myocardial infarction by a genome-wide association and platelet systems biology study'.

assistant: **Objectives**

The overarching objective of the ITN is to offer an intercalated study environment for young and talented researchers in the field of coronary artery disease (CAD) research.  12 PhD fellows operating in a unique training environment will work as a multi-disciplinary team to perform research spanning the full spectrum from basic to translational to bring novel inventions to the bedside.  The fellows will be mentored by world-leading experts to shape a new generation of European leaders in biomedical science and overcome current fragmentation in Europe.  The research is at the forefront of biomedical science because of the UK genome-wide association study in 2000 myocardial infarction (MI) patients and our EU-FP6 integrated projects Bloodomics and Cardiogenics.  We will exploit our knowledge about the genetic architecture of MI to investigate the hypothesis whether sequence variation of genes encoding network hubs poses a greater risk for network destabilisation compared to genes encoding regular nodes.  Focusing on three hub genes we postulate that genetic/bio-markers associated with hubs can be integrated in algorithms for MI/CAD risk prediction.    Success will critically depend on new developments in computing, machine learning, pattern recognition and advanced data mining and statistical analysis.  To have a free development path from basic discovery to health care improvement young scientists must be taught to cross the classic barriers between academic disciplines.  We offer a timely and necessary alternative to Europe’s classic PhD programmes by providing a seamlessly integrated multi-disciplinary environment in an academic-private sector partnership free of boundaries.      Our aim is a targeted strategy for prevention and treatment based on a better understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Safety at speed (S@S)'.

assistant: **Innovation**

Congestion on European roads and railways, and indeed in EC airspace, is becoming an ever-increasing problem. Currently, the economic losses relating to this congestion is estimated to a staggering 2% of the EC gross national product. One of the main remedial actions is the change of cargo routes from road to sea, which however raises the issue of quality and safety in waterborne transport, also in the part undertaken by high speed craft (HSC). The objective of S@S is to develop a formalised methodology for design for safety of HSC using state-of-the- art techniques and tools. The main deliverable from the project is tools that will enable HSC designers to reach an optimal solution with regard to safety and through-life cost. In addition to EC inner market transport benefits, project results are expected to increase European HSC shipbuilding competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Phage co-infection: a missing link in deciphering phage co-evolutionary dynamics', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Phage genomes represent an impressive mosaicism with different genomic regions having distinct evolutionary histories resulting from horizontal gene transfer. By initiating an estimated 10^25 bacterial infections globally every second, phages encounter and recombine with DNA of the host or of prophage origin, further adding to their genome mosaicism. Accumulating evidence, including from my work, suggest that the simultaneous infection of bacterial host by multiple phages (co-infection) could also be an important driver of phage genome evolution. However, methodological limitations have so far prevented rigorous testing of this hypothesis due to failure of studying phage co-infection in natural settings. MULTIPHAGE will overcome these limitations by developing a novel approach for precisely deciphering how phage co-infection governs the co-evolutionary dynamics of phage genomes by pursuing three objectives. First, my team will quantify the prevalence of phage co-infection by constructing phage-host infection networks. Then, we will decipher the co-evolutionary relations of phage genes with no detectable sequence homology, using the novel concept of clusters of orthologous structures (COSs) and reconstructing structural phylogeny. Finally, we will unearth phage-phage interaction and co-infection strategies in high resolution by taking advantage of cultured model systems containing multiple phages co-infecting a single bacterial host population. To achieve these objectives, we will combine integrated omics methods (metaHiC proximity ligation, long-read metagenomic sequencing, and single-cell amplified genomics), COSs and structural phylogeny with high-resolution experimental confirmation of co-infection strategies. With its ground-breaking approach, MULTIPHAGE will transf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Sustainability Optimization for Secure Food Systems'.

assistant: **Concept**

In the current environmental emergency, the food system has to become more productive, inclusive, sustainable, and resilient. SOSFood will therefore use data-exploitation and AI-based technologies to provide a holistic and comprehensive image of the EU food system and develop tailored predictive tools to support well-informed decisions of all stakeholders of the food chain, with a multi-factorial, multi-actor and multi-scale approach, thanks to its multidisciplinary consortium of experts, from private and public sectors, academia research and food system representative (consumers, producers and industries). Although several initiatives have been taken in the same line, none has fully succeeded at considering the global picture of the system or delivering a reliable and accessible message to the target audience. Hence, SOSFood will result in a consolidated food data space focused on sustainability and health and decision-making tools adapted to each level of the chain (a predictive dashboard displaying data and predictions for industries, and a mobile app for consumers comprising an eco-healthy fingerprint visualization plot, a greening indicator of industries, reformulated European recipes promoting healthy, local and seasonal ingredients and general recommendations), following these steps: (1) creating a multi-actor network gathering social, political, legal, economic, technological, food, health, environmental and climatic data, promoting transparency and data-sharing, (2) mapping the food system scenario with a multidimensional strategy, exploiting the interoperability of data with advanced impact analysis and innovative AI-technologies, (3) co-designing solutions i.e., decision-making tools fitting the context and priorities of each user, validated through field cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High sensitive analysis of pesticides' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Development of a new, universal principle for an ultra sensitive analysis of pesticides Our research includes the basic researches as well as measurements of environmental samples using an flow system. The analyzed pesticides are reversible inhibitors (carbamates) and irreversible inhibitors (organophosphorous compounds) of cholinesterase.The new concept consists of three parts:1. pre-incubation: The inhibitor of the sample binds to the active site of labeled butyrylcholinesterase.2. separation: The remaining, not inhibited sites of labeled butyrylcholinesterase are removed by an affinity support3. display: The marker of the not bound inhibitor complexed cholinesterase creates a signal proportional to the concentration of the inhibitor. By optimizing the three parts of the analysis it will be possible to detect the pesticide in five till ten minutes. This would be the fastest and most sensitive pesticide detection carried out so far. Before applying the flow system basic tests will be carried out in the batch.The main points of research are :- synthesis and characterization of affinity supports with varying reversible inhibitors of cholinesterase and different spacers. This allowing regeneration of the support .- synthesis, purification and characterization of cholinesterase-marker-conjugate: possible markers are enzymes, chemiluminescence and fluorescence compounds -kinetic measurements of cholinesterase with various inhibitors- batch measurements of reversible and irreversible inhibitors of cholinesterase including real-samples with different optical displays- automatized flow injection analysis- development of a new analyzing apparatus and measurement of rea-samples on the spot.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum and String Cosmology with Branes and Fluxes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal promotes a research program in theoretical cosmology to be carried out by M. Schillo at the Institute of Theoretical Physics at K.U. Leuven. The aim of the research will be to address two of the pressing issues in modern cosmology: the lack of a reliable framework in which we can describe accelerating, vacuum dominated universes (such as our own), and the necessity for a theory of quantum gravity to describe the early universe.  These problems have recently been impressed upon the cosmological community by the findings of the Planck satellite and the BICEP2 experiment, which provides ample motivation for the integration of high-energy physics and cosmology.  Additionally, the fresh outlooks and theoretical models that this program is designed to produce will be necessary for the interpretation of findings of the next generation of ESA missions; without meaningful theories for the data to either support or falsify, the full potential of these missions cannot be realized.  The innovative approach which will allow this research to contribute to the state-of-the-art in cosmology and move towards solutions to these problems is the combination of newly discovered dynamics and processes in string theory, which M. Schillo developed in her previous research, with the technologies of quantum cosmology and advanced string theory compactifications, in which the faculty of the high-energy group at K.U. Leuven are world-experts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Building Collaborative Urban Drainage research labs communities' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The EU’s Urban Drainage Systems (UDS) have been valued at 2.5 trillion€. They are critical infrastructure providing flood risk reduction, safe sanitation by limiting contact between people and pathogens, and environmental protection by returning treated waste and storm water securely to the natural water cycle. Many UDS are at risk, their economic life is coming to an end and it is unclear how low operational knowledge, population growth, the climate emergency, and public health threats caused by emerging pollutants and pathogens can be addressed. Co-UDlabs brings together 17 unique ‘field scale’ urban drainage experimental facilities, providing innovation, collaboration and high level training opportunities. The main aim of CO-UDlabs is to integrate research and innovation activities in the field of UDS to address these pressing challenges and provide opportunities for pervasive monitoring of water quality, UDS performance and smart and open data approaches. The advanced Co-UDlabs facilities are run by experienced research groups with extensive industry networks and strong records of innovation. Co-UDlabs delivers Transnational Access to these facilities to enable the scientific community and industry innovators to develop and validate internationally leading innovations before safely deploying them in full-scale UDS. CO-UDlabs will conduct interlinked Joint Research Activities to enable faster and wider uptake of innovation in traditional buried pipe systems and newer green-blue infrastructure, specifically focusing on increasing our understanding of asset deterioration and improving system resilience. Also, CO-UDlabs will develop innovative smart monitoring technologies, digital water analysis tools and foster the innovation potential of human resources. CO-UDlabs wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '“Solid phase synthesis, biophysical study and biological evaluation of cyclic glycopeptides for inhibition of protein protein interactions”' under Seventh Framework.

assistant: **Concept**

Dr. Jarikote, an Indian national who has recently completed his PhD in Germany and is currently working with Prof. Dr. Paul Murphy. It is proposed that Dr. Jarikote will work on solid phase synthesis of cyclic glycopeptides and their biophysical characterization with a view to generating novel inhibitors of protein-protein interactions, in particular those that involve a-helices. He will also receive training in carbohydrate chemistry, scaffolds, NMR and molecular modelling and their application to the design of bioactive compounds wherever necessary. The biophysical characterisation will also carried out and techniques such as NMR and fluorescence will be used to investigate binding of synthetic ligands to targeted proteins. Such synthetic mimics could have wide pharmaceutical importance as they have potential to be bioavailable mimics of peptides that modulate protein-protein interactions. The proposal is of interdisciplinary nature, collaborating ultimately with physical chemists and cell biologists and will focus on the design, synthesis and biological evaluation of novel proteomimetics or peptidomimetics based on macrocycles comprised of saccharide structures.  Mimetics of the surface of the Bak peptide (an alpha-helical peptide) based on glycopeptides will be synthesised on the solid phase and the products will be evaluated for their biophysical properties effects on promoting apoptosis in tumour cells. The solid phase synthesis approach will give rise to rapid access of numerous derivatives of target oriented glycopeptides in short time period. The glycopeptides design will be based on ensuring the presentation of pharmacophoric groups in a spatial orientation that matches that of residues at i, i+4 and i+7 of the relevant α–helical peptide, in this case the BAK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new generation car seat for babies' (SAFESEAT) targeting Horizon 2020.

assistant: **Abstract**

Child Restraint Systems (CRS) for the safety of children travelling by car are used in close to all cases in industrialised countries, and it is often required by law. These systems, when installed and used correctly, considerably reduce the impact of an accident on the child, thereby reducing the risk of injury and death. However, despite the extensive use of CRS, thousands of children die and many more are injured in car accidents every year. The fact that the CRS available on the market are still based on the same concept as 30 years ago, as well as the high human factor of incorrect use reducing the efficiency and safety of the system in many cases, show that there is room for considerable improvement in this field.For several years Mobius Protection Systems has been designing and manufacturing Energy Absorbing (EA) solutions based on an innovative technology. Following successful use of the solution in army vehicles, Mobius is now looking to enter the civil market and in particular the CRS industry. By applying the Mobius technology to CRS the impact on the child during an accident can be considerably reduced, and tests have shown results which are better than leading seats available in the market today. In addition, through the SAFESEAT project Mobius aims to reduce the impact of the human factor. Both incorrect use and the possibility of forgetting the child in the car, something which has been fatal in many cases, will be addressed through a system of sensors and notifications via the smart phone of the parent. Finally the project will reduce the weight and increase strength of the CRS, by using composite materials instead of the traditional materials used, increasing safety and the comfort of the user.During Phase 1 of the project Mobius plans to further deepen