RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Heavy and Extractive industry wastes PHAsing out through ESG Tailings Upcycling Synergy' under Horizon Europe.

assistant: **Concept**

The HEPHAESTUS project is built around one key, overarching objective:To develop a set of scalable and tuneable unit operations, to be built as integrated processing plant, featuring the capacity to treat multiple process wastes deriving from primary mineral and metallurgical (primary and secondary) streams.  The unit operations are:-Clean-Tech electric furnace, to transform the EAF and AOD dust into metal alloy to be immediately remelted, process supported with streams of fines by-products from the mineral primary extractions (construction, aggregates and dimensional stone)-EZINEX process, to extract the zinc present in the dust of the furnace-Fibre drawing, for mineral wool manufacturing out of the process slag in molten state-Catalytic conversion of CO2 gas into methanol or formic acid-Ammonia-ammonium carbonate (AAC) and methanesulfonic acid (MSA) based hydrometallurgical processes, to produce a recyclable Fe-rich residue and to recover metals (e.g.e.g., ZnS) from EAF dustThe project is targeting primarily small-scale applications (order of magnitude 10 k tons waste dust per year), to cope with the typically fragmented European process size. Such scale is matching the waste volumes and differentiation and granting positive environmental AND economic sustainability through the valorisation of different streams of by-products at low operational and capital expenditure, ensuring vast replicability and short ROIProject will be demonstrated in two pilot applications, in Greece and Italy, with the purpose of creating awareness on the business potential and to generate the conditions for a long-term exploitation, leading to meaningful reduction of wastes for the extractive and steel industries.


**Keywords:** Steel Dust recycling; Recovery of mineral fine dust tailings; P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project '“Science against Poverty” Conference under the Spanish Presidency'.

assistant: **Objectives**

The “Science against Poverty” Conference represents the most visible action during the Presidency Term under the Inclusion heading. It aims to convey a clear message to society on the contribution of science and innovation to the fight against poverty and exclusion. In February 2010 the Ministers for Research provided ample support and compromise to advance towards a more responsive science under the Donostia Declaration.The Conference will gather scientific, political and societal stakeholders with the aim of creating a forum for a focused debate on the role science can play in the fight against poverty and exclusion and of suggesting policy recommendations for a more effective design of European and National research and innovation policies. Its conclusions will reach the agenda of the Competitiveness Council of Ministers of the EU on 26 May 2010.The topic of the conference covers multiple facets of knowledge and action: some as urgent as global access to innovative medical technologies and medicines and the fight against the digital gap, but also an understanding of the social dynamics that cause poverty and the mechanisms to create and maintain economically sustainable communities, without overlooking how to involve all the players in this challenge and the promotion of social entrepreneurship.Next to plenary sessions of a more political nature, the Conference will include both thematic sessions (food and nutrition; dynamics of poverty; technological gap; energy; environment and climate change; water and sanitation; health) and cross-disciplinary sessions (stakeholders involvement; education and training; innovative solutions; gender issues; social sciences and poverty; sustainable business).Witin this general objective, the “Science against Poverty” conference will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mycorrhiza technology for staple food crop production in small- scale sustainable agriculture in china' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Arbuscular mycorrhiza technology will be applied as an innovative tool to enhance staple food crop productivity in small-scale Chinese farming systems, by improving soil fertility and particularly phosphate availability which is low in most agricultural soils in China. A Chinese stock centre of arbuscular mycorrhizalfungi from north, central and south China will be established and germ plasm registered in an on-line database. Isolates with high symbiotic efficiency will be propagated on a large scale as quality-controlled inoculums and directly introduced into production systems of sweet potato, maize and cassava traditionally used in small farms. Improved crop yields and persistence of introduced inoculums by molecular monitoring will be criteria of inoculation efficiency. Success of the project relies on close cooperation between European and Chinese research institutes, SMEs and end-users (farmers)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INtroDucing axial rEsolution in oPToelectronic implantable devices for tHe brain' in the context of a Horizon 2020 call.

assistant: **Objectives**

IN DEPTH aims at developing the first brain implantable device able to gather simultaneously electrophysiology and optical signals with depth resolution and reduced invasiveness. Neuroscientists and neurosurgeons are indeed still limited in accessing and addressing deep brain structures, while the field would instead greatly benefit of low-invasiveness probes monitoring bio-electronic and optical signals with spatial resolution, for both neuroscience and neurosurgery applications.IN DEPTH will answer to the stakeholders needs with a close-to-market fully-integrated device based on minimally invasive tapered optical fibers (TFs) for multipoint light collection and electrophysiology. The system aims at novel applications in both neuroscience research and neurosurgery, with particular reference to cerebral disfunctions including Parkinson’s disease, schizophrenia, or epilepsy, and to fluorescence-guided resection of brain tumors, giving neurosurgeons the possibility to check also the tumor depth and monitor electrical activity during surgery.These aims will be achieved by implementing innovative and high-throughput fabrication process developed for non-planar surfaces, aiming at full compatibility with bench-top equipment for electrophysiology, optophysiology and neurosurgery.


**Keywords:** Photonic implantable devices, optoelectronic implantable devices, optical neural interfaces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Aberrant ubiquitin-mediated proteolysis in oncogenesis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ubiquitin-proteasome system controls molecular networks that underlie fundamental cellular functions such as DNA replication, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. A large body of experimental and clinical data indicates that defects in the ubiquitin-dependent protein degradation are intimately linked with cancer pathogenesis. The main objective of our research is the elucidation of the molecular mechanisms by which deregulated function of SCF ubiquitin ligases contribute to oncogenesis. To achieve our goal we propose the following aims: Aim 1. To identify novel substrates for SCF ubiquitin ligases that have been shown to play roles in tumorigenesis. Aim 2. To identify ubiquitin ligases for tumor suppressor proteins and proto-oncoproteins that are targeted by the ubiquitin-proteasome pathway. Aim 3. To determine the contribution of defective SCF-mediated degradation to cancer.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Additional Innovation support services for Enterprise Europe Network in Eastern France' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Providing Enhancing innovation management capacity services to high potential SMEs and Key account managementservices to beneficiaries of the SME Instrument in the 5 regions of Eastern France through an additional workpackage of theEnterprise Europe Network EEN GRAND EST - 649194 consortium for 2015 - 2016


**Keywords:** innovation management, SME instrument, key account management, enhancing capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Vertical Markets and Cooperative Hierarchies: The Role of Cooperatives in the International Agri-Food Industry' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

It is envisaged that after the two conferences proposed in this Project the participants will have accomplished two objectives: First, to comprehend and learn to apply the new developments in industrial economics and organisation theory in their research on agri-food cooperatives. Second, they will present their own research and find out of the research of others in the area of agri-food cooperatives. These objectives will be accomplished by inviting key researchers in both theoretic and applied research, as well as industry leaders to discuss current and future issues of agri-food cooperatives. The two conferences of the series will accommodate two main themes concerning, agri-food cooperatives.The first event will deal with issues of competition and organisation, whereas the second will focus on strategy.The topics are divided into four themes, one for each day: 1. Market Structure, Competition and Industrial Policy. Since agri-food cooperatives are integral part of agri-food chains, it is very crucial to discuss the state of the art in research on industrial organisation and competition policy; 2. Cooperative Governance. It is becoming increasingly evident that internal organisation is of key importance to a cooperative. How this relates to conduct and performance of a cooperative, is the underlying question concerning the second day; 3. Technology, Innovation and Re-Organisation. Biotechnology and genetics and how they relate to competition and organisational aspects of agri-food cooperatives, will be the topic of the third day; 4. Food Distribution and Final Demand. After all, agri-food cooperatives are catering the needs of extremely diversified consumers world-wide. How these needs are formed and how is the retail and distribution system evolving, are the topics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analysis of Tenascin C function in breast cancer metastasis to bone' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Metastasis is the spread and outgrowth of cancer cells in organs distant from the site of origin. In breast cancer, the bone is the most common site of metastasis and metastatic outgrowth in the bone causes hundreds of thousands of deaths world-wide every year. In recent years it has become evident that stem cell characteristics play an important role in cancer progression and metastasis. These characteristics are not only intrinsically determined but also maintained and even induced by the microenvironment — the metastatic niche — suggesting a very complex interaction between cancer stem cells and their niches. We have identified an essential niche component for metastasis of breast cancer. This component is the extracellular matrix (ECM) protein tenascin C (TNC). We demonstrated, that in the context of lung metastasis, TNC engages stem cell signaling pathways to promote fitness of metastasis initiating cells. Moreover, we demonstrated that TNC is also crucial for breast cancer metastasis to bone. However, the cellular functions and signaling mediated by TNC and the surface receptors TNC engages in disseminated breast cancer cells growing into bone metastasis is unknown. We aim to address this in an integrative way using 3D culture systems of primary cancer cells, RNA interference, transcriptomic and proteomic screens, genetic- and xenograft -mouse models of cancer progression and metastasis. Moreover, we aim to use mouse models to address if inhibiting TNC, TNC-receptors or downstream signaling can sensitize bone metastasis to therapeutic intervention.  Increasing evidence suggests that proteins of the extracellular matrix (ECM) support the fitness of disseminated cancer cells at distant sites, facilitating metastatic outgrowth. Targeting these components may provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional cofactors for targeted modification of biomolecules' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Enzymatic addition of a methyl group (methylation) is the most prevalent natural modification in cells, serving a myriad of regulatory and structural functions. Abnormal methylation of DNA, RNA or histone proteins can lead to severe developmental defects and is associated with numerous human diseases. Selective methylation of biomolecular targets is carried out by dedicated methyltransferase enzymes, which use the cofactor S-adenosyl-L-methionine (AdoMet) as the source of methyl groups. Despite the high specificity and impressive diversity of MTases, the deposited methyl groups are poor reporters and hardly amenable to further derivatization. To unlock the biotechnological power of MTases, strategies for repurposing these enzymes into targeting vehicles for the transfer of useful extended groups from synthetic AdoMet analogs have been devised. However, despite substantial advances over the past decade, a widespread adoption of this enabling technology in scientific labs and clinical settings was grossly hindered by the poor availability of such synthetic cofactors. This proposal, footed on findings of our ERC-funded work, will seek to overcome the limitations of chemical synthesis and adapt our recently developed chemo-enzymatic protocols for low-cost industrial production of functionally competent AdoMet analogs. We will also seek the transfer of the technology to an industrial partner for its commercial exploitation and to ensure broad access of these valuable reagents to the scientific community and commercial stakeholders.


**Keywords:** S-adenosyl-L-methionine analogs,  AdoMet-dependent methyltransferases,  biocatalytic S-alkylation,  chemo-enzymatic production,  bio-orthogonal labeling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Efficacity of RSH28GST as an antifecundity vaccine against schistos omahaematobium infection (II): Immune mechanisms in experimental models andin man'.

assistant: **Innovation**

To evaluate a well-founded vaccine strategy against the trematode parasite Schistosoma haematobium by evaluating : * the immune responses towards, the 28 kDa glutathione S-transferase (Sh28GST) and its major epitopes, in infected human populations in three endemic areas;* the present epidemiological status and transmission process in each endemic area;* the feasibility of the use of new mucosal delivery systems for the recombinant subunit vaccine. In addition, the project will promote the development of south-south collaborative research between the participating DC partners, in terms of technological and staff exchanges. The bi-directional programme (North-south) for research training which took place in 1995 for the cellular immunity analysis and epidemiological and medical studies, will be continued.Expected OutcomeThe epidemiology and immuno-epidemiological studies on S. haematobium infected populations will give us an up to date view of the parasitic status and the specific immune status of the targeted populations allowing us to prepare the appropriate schedule for vaccine trials in infected populations (phase 2; Sh28GST in Alum), which is planned in 1999. The studies on the proposed new vaccine formulations for mucosal immunisation will be the last step of their evaluation. Their efficacy will be confirmed, and their capacity under field conditions will be evaluated.The project will ensure the training of DC partner technicians, doctoral and post-doctoral students and technology transfers, notably between the DC partners. We place particular emphasis on the development of this collaboration in the context of the regional integration of research efforts against infectious diseases.* Epidemiological survey of S. haematobium infection in Senegal, Niger and Madagasca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cryogenic Magic Angle Spinning For Nuclear Dynamic Polarization' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We intend to develop a new nano-characterization technique able to complement the tools currently available (AFM, TEM, XPS etc.) and to palliate the inadequacies and/or sensitivity limitations of atomic resolution techniques such as X-ray diffraction and solution NMR. Indeed, despite their success to resolve structures, they do not contribute as much to the tremendous ongoing advances in nanoscience: i.e. development of molecular memories, molecular electronics, nano-biosensors, etc. The reason relies mainly in the intrinsic nature of the samples involved (either non-crystalline or insoluble materials) and the subsequent poor detection sensitivity associated. The objective of the project is to develop a particular form of solid-state Nuclear Magnetic Resonance able to enhance the nuclear spin sensitivity by 4 to 6 orders of magnitude. To achieve this objective, we will use a high power microwave source to irradiate the unpaired electron spins (contained in optimized polarizing agents) in order to hyperpolarize surrounding nuclear spins through a mechanism called Dynamic Nuclear Polarization (DNP). The experiments will be conducted at high magnetic field, with a temperature ranging from 10 to 300 K and rotation of the sample at the magic angle in order to retain high resolution NMR conditions. The project also intends to demonstrate the pertinence of the approach for atomic structure determination of challenging nano-systems beyond reach by other techniques, e.g. functionalized nanotubes/molecular wires, paramagnetic systems (porphyrins, proteins, etc.) as well as very large non-crystalline and insoluble biomolecular systems.