RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SPAce exploration Research for Throttleable Advanced eNgine', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The SPARTAN research aims at developing a throttable propulsion technology, which is mandatorily needed for any planetary soft and precision landing. It relies on the hybrid engine technology, exploiting its capability of being throttled and its proper performances.This research is complementary to ESA TRP and Piedmont Regional development programs. It implements and strengthens the technological base in view of the future robotics and manned space exploration missions.The outcomes from the SPARTAN development can be reflected also in many other Earth/Space civilian applications, exploiting both the throttling capability of the propulsion system and the peculiar characteristics of the hybrid engine technology, like: safety, minimum environmental impact (green propellants), lower life cycle costs, responsiveness, competitive Performances, increased reliability, soft ignition and shutdown. The hybrid propulsion system is formed by two major constitutors: the engine itself, housing the fuel, and the oxidizer injection system.The research focuses on three major objectives, needed to achieve the soft and precision landing capabilities: The engine design, specific for throttling functionality The oxidizer throttable device development The design of the landing case: test bench and testing proceduresDevelopment will be supported by establishing an advanced coding, enabling the definition of the fuel and the throttling behavior of the hybrid engine. Engine definition will be supported by development tests: cold injection case on subscale model, dedicated to the throttling device, and hot firing on lab model, merging the throttling device and the engine model.In parallel a landing test and associated landing model (flying test bed) will be developed, providing for proven land
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Treat 2000 - treatment system research on european addiction treatment' (1998-2002).

assistant: **Innovation**

The TREAT 2000 projects aims at three objectives: A detailed comparative description of health care systems provided for opioid addicts in six European regions, a follow-up study of 150 opioid addicts over 18 months in these regions including their utilisation of the system and a comparative evaluation of the different systems by relating outcome measures of the follow-up study, especially, social functioning and drug free days with the utilisation of the systems and the kind of provided help. Additionally, a comparative assessment of the costs of the regional systems and first steps to an approximate cost-effectiveness evaluation will be carried out. TREAT 2000 will be the first study of this kind. Its results will be of importance for improving local and, in particular, European health care strategies for drug addicts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Gender Equality Network in the European Research Area'.

assistant: **Concept**

With the main goal to address gender equality in Research & Innovation the proposing GENERA (Gender Equality Network in the European Research Area) consortium has been formed to apply a bottom-up approach to enhance gender equality in the field of physics research as a benchmark for other sciences. Physics is a research field with a low representation of female researchers and a masculine image, so this field as such being represented by different actors will be the basis for GENERA analysis and interventions. GENERA comprises a starting set of organisations active in the field of physics, which are committed to the implementation of the project and to the achievement of its milestones. The consortium proposing the project will be extended to involve other interested major physics research organisations in European countries as associate partners.The GENERA consortium requests funding to support research organisations in implementing gender equality plans and proposes the following coordination and support actions with a focus on physics research and a keen eye on cultural differences throughout Europe by the following steps:1. Assess the status of gender issues in the partner organisations.2. Identify gaps in existing Gender Equality Plans (GEPs) and determine specific needs or actions to enhance gender equality and women careers in physics.3. Monitor and evaluate the existing activities of the involved organisations (partners and associates).4. Formulate customized GEPs for all implementing organizations and create a roadmap for their implementation in physics with the potential of application in other research fields.5. Support involved organisations in implementing customized GEPs.6. Create a network of RPOs, HEIs and RFOs to promote gender equality in physics.7. Se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing arthropod predation on parasitized hosts in organic and conventional farming systems' in the context of a Sixth Framework call.

assistant: **Objectives**

Insect natural enemies play a key role for pest control in sustainable farming systems, however relatively little is understood regarding the trophic relationships within the natural enemy community and their effect on the level of biological control. The pro posed project addresses this lack of knowledge, as it will quantify arthropod predation on parasitized hosts by using, for the first time, a molecular approach. This will enable us to track the effects of predation on quantitative parasitoid food webs in organic and conventional farming systems and reveal the impact of the predators on the level of pest control.There are three main objectives to this research program:1. To establish a molecular method for detecting parasitoid DNA within predators that has eaten parasitized hosts. Furthermore, rapid screening techniques will be evaluated for their utility to make the task of screening large numbers of field samples rapidly easier.2. To screen field-collected predators for DNA of parasitoids and their hosts.3. To compare parasitism rates with predation rates on parasitized hosts in organic and conventional farms, and quantify the effects of predation on quantitative parasitoid food webs.If predators are selectively taking parasitized hosts this may actually inhibit t he rate of growth of the parasitoids population and have negative consequences for pest control. The outcomes of this project will provide an important proof of concept for further research looking at the effects of predator-parasitoid interactions on natural pest control. The applicant will benefit greatly from the period of advanced training as (i) the host institution is at the fore front internationally in this research field, (ii) high quality infrastructure is available for the execution of the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Celiac Disease HLA typing using microfabricated genoSENSarray' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Coeliac disease (CD) is a gluten-sensitive enteropathy that affects as much as 1% of the population. Patients with CD should maintain a lifelong gluten-free diet, in order to avoid serious complications. It is essential to diagnose CD at the earliest possible conjecture. The Human Leukocyte Antigen system (HLA) is the human major histocompatibility complex. HLA typing is fundamental in hystocompatibility and previous to solid organ and bone marrow transplantation. In CD, HLA typing can find application in establishing the genetic risk and the association between certain HLA types. The overall objective of CD-HLAsens is therefore to develop a generic technological platform for CD point-of-care diagnostics capable of genomic detection with electrochemical transduction. Genosensors microarrays for the screening of CD disease will be developed based on the detection of nucleic acids associated with genetic predisposition, i.e. HLA typing. Such detection strategy could be used for general population screening but also for neonatal screening. Together with classical assay formats, novel biomolecule detection schemes based on supramolecular associations will be developed with the aim to fine tune the specificity and sensitivity of the sensors. The Researcher will design, new surface chemistry for the functionalisation and operation of the genosensors arrays based on the experiences gained during his previous MC fellowship and new research avenues he has identified (novel sensor surface patterning, electrochemical detection schemes for low resolution HLA typing). In addition, the researcher proposes to continue the successful development of a microfabricated genosensors array, focusing on sensor and microfluidics integration as well as connectivity issues (on chip integration a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel approaches for the development of customized skin treatments and services  (Test case: Dead Sea Minerals and Conventional drugs)' to be submitted under Seventh Framework.

assistant: **Abstract**

Economical and health interests of skin problems are fast growing issues in Europe, following the remarkable extension in life expectancy in western countries, together with the increased awareness of UV radiation risks. Personalized health care approach has been discussed over the past few years and had been accompanied by developing innovative technologies capable of identifying specific biomarkers, supporting a personalized diagnosis and treatments, especially concerning bio-compatibility of drugs. Skin Treat intends to develop and validate nano-chemical and bio- technologies to achieve an accurate matching of drugs, and drug delivery vehicles, to skin diseases and sub pathogenic skin conditions in their individual context. The project will design novel generation of pharmaceutical products, as well as consumer personalized service, in order to fit customers’ tailored needs with a support of strategic consortium based on partnership among SMEs and research organizations. The development of personalized skin therapy protocols requires achieving an accurate diagnostics of skin condition and an extensive analysis of biological markers. Non invasive methods as well as minimal invasive skin sampling, will support the establishment of a range of biological profiles corresponding to skin diseases and skin sub pathologic conditions. Statistical processing of these data will allow defining biomarkers patterns specifically associated with given clinical conditions. A bio-informatics data mining protocol will be elaborated, together with multifunctional biomarker analysis software, to build a refined, personalized diagnosis method. Finally, the computer data analysis will yield a decision support system (DSS) to assist dermatologists, chemist and clients for prescription of per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Directed Evolution in vivo enabled through genetic circuits in a Synthetic Biology approach' under Seventh Framework.

assistant: **Concept**

Given our limited ability to rationally design proteins to our needs, their supply for biotechnological solutions leading to a sustainable Bioeconomy is relying on proteins found in nature and methods for deriving improved versions. Proteins evolved their structure to fulfil certain functions in very specific niches, but these do not resemble optimal properties in the new context of biotechnological applications. Hence, improving the activity, affinity and stability of a protein is key, but technologically challenging. The current methods for improving proteins through directed evolution require intense human intervention and are limited in their ability to sample sequence space beyond single and double mutations. This project will establish a novel system, in which the whole process of mutation and selection takes place in vivo inside an E. coli host, and can be controlled through a genetic network designed using a Synthetic Biology approach. It will allow for the exploration of a larger sequence space during the evolutionary process, while controlling mutagenesis rate and selection stringency. Our preliminary data demonstrates a groundbreaking novel method to target mutagenesis in vivo. I will extend its mutation diversity by recruiting engineered error prone polymerases to the site of the targeted DNA damage. Using a SynBio approach, I will develop a control circuitry, which will stop the targeted mutagenesis activity, once a variant fulfils the selection criteria. While protecting the identity of the selected sequence, it will mark the successful cell by expression of a fluorescent reporter for selection. In a prototype application I will generate variants of the Quorum Sensing transcription factor, LuxR, with high affinities to different signalling molecules – a po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evolution of cell fate specification modes in spiral cleavage', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Spiral cleavage is a highly stereotypical early embryonic program, and the ancestral, defining feature to Spiralia, a major phylogenetic clade including almost half of the animal phyla. Remarkably, spiral-cleaving embryos specify homologous cell fates (e.g. the progenitor cell of posterodorsal structures) conditionally –via cell interactions– or autonomously –via segregation of maternal inputs. This variation occurs naturally, even between closely related species, and has been related to the precocious formation of adult characters (adultation) in larvae of autonomous spiral-cleaving species. How spiralian lineages repeatedly shifted between these two cell fate specification modes is largely unexplored, because the mechanisms controlling spiral cleavage are still poorly characterized.This project tests the hypothesis that maternal chromatin and transcriptional regulators differentially incorporated in oocytes with autonomous spiral cleavage explain the evolution of this mode of cell fate specification. Through a comparative and phylogenetic-guided approach, we will combine bioinformatics, live imaging, and molecular and experimental techniques to: (i) Comprehensively identify differentially supplied maternal factors among spiral cleaving oocytes with distinct cell fate specification modes using comparative RNA-seq and proteomics; (ii) Uncover the developmental mechanisms driving conditional spiral cleavage, which is the ancestral embryonic mode; and (iii) Investigate how maternal chromatin and transcriptional regulators define early cell fates, and whether these factors account for the repeated evolution of autonomous specification modes.Our results will fill a large gap of knowledge in our understanding of spiral cleavage and its evolution. In a broader context, this p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reduction of occupational asthma and dermatitis in the vehicle repair industry' in the context of a Sixth Framework call.

assistant: **Objectives**

SAFEWORKER will develop styrene-free, vehicle body repair filler that will be rapidly cured by UV lamps resulting in faster turnaround of repairs at reduced cost. Reducing the process time will allow Europe's bodyshops to increase their throughput & therefore revenue generation potential whilst eliminating Styrene & other VOCs from the filler. Such a development, freely disseminated through the trade associations within our sector will allow ALL of Europe's 172,000 SMEs within our sector to comply with Council Directive 98/24/EC 'on the protection of the health and safety of workers from the risks related to chemical agents at work'.More than 98% of firms in our sector are SMEs and 83% of them employ less than 50 people. The number of cars in Europe totals 184,426,000 & is growing at 2.3% per annum. The market for accident repair has never been so buoyant. However, our industry faces a resource & skills shortage that threatens the sectors ability to satisfy future market demand. The increase in public awareness of environmental & occupational health hazards has caused worker reluctance to enter our sector due to the perceived health risks & potential reduction on quality of life. Occupational skin disease and respiratory disease effects over 100,000 workers in the European vehicle repair sector, costing the industry around 100 million Euro per annum.These forms of skin disease & asthma are caused by exposure of our workers to specific chemicals, found in the polyester filler they use to fill dents in damaged vehicles. Our industry generates approximately 300,000 tonnes of styrene emission in Europe every year from our repair-shops. Styrene is classified as a possible human carcinogen by the Environmental Protection Agency (EPA) and by the International Agency for Resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Partnership on Radioactive Waste Management - 2' (EURAD-2).

assistant: **Concept**

Our VisionWith the European Joint Programme on Radioactive Waste Management EURAD(-1) a step change in European collaboration was envisaged towards safe radioactive waste management (RWM), covering all phases including predisposal and disposal, through the development of a robust and sustained science, technology and knowledge management programme that supports timely implementation of RWM activities and serves to foster mutual understanding and trust between Joint Programme participants.EURAD-2 builds upon EURAD-1 and PREDIS to further implement a joint strategic programme of research, development and knowledge management activities at the European level, bringing together and complementing EU Member States programmes in order to ensure cutting edge knowledge creation and preservation in view of delivering safe, responsible and publicly acceptable solutions for the management of radioactive waste throughout all programme phases (from “cradle to grave”) across Europe now and in the future.EURAD-2 will support the implementation of the Waste Directive in EU Member States, taking into account the various stages of advancement of national programmes, the differences in capabilities and inventories.  The main goals are to:-Support Member States in developing and implementing their national RD&D programmes for the safe long‐term management of their full range of different types of radioactive waste through participation in the RWM Joint Programme;-Develop and consolidate existing knowledge for the safe start of operation of the first geological disposal facilities for spent fuel, high‐level waste, and other long‐lived radioactive waste, and supporting optimization linked with the stepwise implementation of geological disposal facilities;-Building on the achievements of EURAD