RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Linking population genomic and behavioural data to test fundamental hypotheses of sexually antagonistic coevolution.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Sexual conflict and sexually antagonistic coevolution (SAC) are compelling hypotheses to explain some of the extraordinary diversity in morphological and behavioral traits observed in nature. However, the study of the genomic foundations of this conflict and the resulting population genetic dynamics are still in their infancy. This is due to a lack of knowledge about the genetic underpinnings of the most well understood sexual conflict traits. An exception to this rule are the seminal fluid and female reproductive tract proteins that interact and mediate conflicts over remating rates in the cosmopolitan model species Drosophila melanogaster. However, in this system a population-level perspective to investigate population genomic signals of SAC and the consequences for outcomes of mating interactions within populations is lacking. Here I propose to take advantage of a Europe-wide population genetic data-set as well as an ongoing pan-European collaborative sampling and phenotyping effort of D. melanogaster to understand how sexual conflict has shaped co-evolutionary patterns at genetic loci involved in sexually antagonistic traits. Furthermore, I will investigate the consequences of this genetic coevolution on contemporary male-female interactions. My proposal has three objectives: i) a population genomic analysis of population genomic data from European D. melanogaster populations, ii) lab-based behavioural experiments to investigate the male-female interactions for inbred lines obtained from populations with extreme patterns of coevolution, iii) and indirect study of the consequences of coevolution on natural behaviour via sampling of wild-caught females and determining mating/re-mating rates. This project will increase our understanding of the role of sexual conflict a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The autonomous assessment of aircraft sound power and position', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Noise is a main pollutant of airports. At present there are two main tools used to manage the impact of airport noise – computer simulated noise contour maps (NCM) and aircraft noise monitoring systems (NMS). Currently both systems have shortcomings. The aim of this research project is to overcome these and improve the accuracy of both systems. NCMs describe the area around the airport affected by a given noise level (allowing the straightforward calculation of the exposed population) while NMSs provide discrete information on the noise level at individual locations near the airport. NCMs rely on noise data extrapolated from aircraft certification tests, which often do not represent accurately the noise encountered on the ground. NMSs overcome this by measuring the actual noise levels. However, NMS data may be influenced by the background noise at measurement sites.The objective of this project is to develop an improved NMS that can supply accurate and timely data to noise simulation software. By combining the two methods, it would be possible to design a comprehensive tool for managing the noise impact of airports. There are three key advantages of the improved NMS: the provision of accurate aircraft sound power data for the entire aircraft trajectory, the removal of background noise influence on measurements, and independence from airport radar systems. This project will place European research on the acoustic impact of airports in a leading position by improving European aircraft noise prediction models.  In addition, it will have an economic impact on the industry, allowing European vendors to offer such an enhanced system to airport management entities globally.  Finally, it will have an effect on European airport noise policy by providing a reliable method of dete
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Immunoglobulin IgY pseudomonas A clinical trial for cystic fibrosis treatment' in the context of a Seventh Framework call.

assistant: **Objectives**

Cystic Fibrosis (CF) is a chronically debilitating and life threatening medical condition. Respiratory insufficiency and complications of chronic lung infection lead to long term reduction in quality of life and health and even to premature death. Chronic bacterial infections with Pseudomonas aeruginosa (PA), Staphylococcus aureus and Haemophilus influezae are typical for CF and repeated courses of antibiotics in heavy doses has more than doubled the median survival age. No preventive or eradicative treatments of PA infection in the lungs exist today. The most significant bacterial pathogen associated with CF pulmonary disease is PA. PA is an opportunistic, life-threatening gram-negative bacteria which produces various immune modulatory products enabling it to survive in the lungs and cause morbidity and mortality. CF patients are particularly at risk of infection due to the viscous mucus lining their airways, which compromises their respiratory function.The European Medicines Agency granted “Anti-pseudomonas IgY” an Orphan Drug Designation in September 2008, and paediatric CF product development was encouraged. The IMPACTT project will perform a clinical phase III trial, to demonstrate the critical preventive and therapeutic effects of this pioneering intervention therapy for the fatal chronic infection of Pseudomonas aeruginosa in CF patients. The project mobilises the critical mass of experts from academia, patient organisations, clinical trials managers, clinicians and industry aiming to eradicate PA infection in CF patient lungs and thereby alleviate the negative impact of PA on the quality of life of CF patients and their families.Despite good results with antibiotics, continuous pulmonary deterioration and death of the CF patient is a reality. Alternative therape
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Esh-angiogenesis' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Angiogenesis research addresses the molecular and cellular mechanisms that contribute to the formation of blood vessels. It is a multidisciplinary area of recent and rapidly growing scientific importance, notably because it holds strong therapeutic potential for a number of human diseases including the two foremost causes of handicap and mortality in Europe: cancer and vascular diseases. Angiogenesis is a field of important human, technological and financial investment in North America and Japan. In contrast, in spite of excellent science and a developing number of European-generated patents, the European angiogenesis research community is insufficiently supported. One result is that there exists no regular high-level European conference on angiogenesis and European scientists must travel abroad to find a regular forum for scientific exchange. European postdoctoral level scientists do not have access to a European forum for high-level training and are largely exposed to offers of postdoctoral positions on other continents.Our objective is to contribute to fill this void by creating a much-needed interdisciplinary forum for high-level training and for interaction between basic, clinical and industrial scientists, at the European level. We feel that this forum will contribute to the level of excellence in this field within the European scientific community, to catalyze trans-European cooperative basic and clinical research projects and to develop the European biotechnology and pharmaceutical industries. This project has already drawn interest and pledged support from industry. These Euroconferences will focus on the molecular mechanisms controlling angiogenesis, vascular development in the embryo, pathological angiogenesis and current clinical trials. Importantly, the fea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bile acids targeting Retinoic Related Orphan Receptor gamma for the Treatment of Obesity associated Insulin Resistance and Type 2 Diabetes' (DIBAROR) targeting Seventh Framework.

assistant: **Abstract**

Within the past three years as part of the ERC funding, we have performed extensive research to identify novel factors that might influence adipogenesis and thus control development of obesity and associated metabolic disorders. One of the factors we identified in a translational approach, was the transcription factor retinoic acid orphan receptor gamma (RORγ) which regulates fat cell formation in mice and humans. RORγ is considered as an orphan nuclear receptor as only weak natural ligands that antagonize receptor function have been identified so far. We were able to identify a high affinity natural occurring ligand (Ba1) which is a bile acid isoform and which potently represses the activity of RORγ. Genetic ablation of RORγ expression can rescue obesity associated development of type 2 diabetes, similarly in mice Ba1 supplementation of the diet, prevents the development of diet induced type 2 diabetes. Thus, Ba1 is a ligand for RORγ that has the potential to serve as a therapeutic agent for the treatment of obesity associated insulin resistance and type 2 diabetes.With this application we would add value to the current state of the project in different aspects. We plan to perform a toxicological assessment of Ba1 which will show if it can enter further development without problems. In parallel a set of well-defined Ba1 analogs will be synthesized with the aim to widen our IP position. Furthermore, we plan a detailed evaluation of the in vitro and in vivo efficacy of the newly synthesized Ba1 analogues. We anticipate that it will be possible to implement this naturally occurring bile acid in the context of two separate therapies. Ba1 can be envisioned to be employed as a nutraceutical in common foods. Also, Ba1 could find a niche in the ever-expanding over-the-counter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TOWARDS A SUSTAINABLE EU-LAC PARTNERSHIP IN RESEARCH INFRASTRUCTURES' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

H2020 EU-LAC ResInfra project served to boost the bi-regional collaboration on research infrastructures (RIs) between European Union (EU) and Latin America and Caribbean (LAC) countries. To this aim a variety of different activities were developed that have proven the importance of RIs as a key pillar in boosting the R&D activities between regions and the need to maintain a sustainable collaboration at governmental level. Despite the success of the results of EU-LAC ResInfra Project, there is still work to do in order to have a solid and sustainable framework of cooperation to enhance the bi-regional collaboration on research infrastructures.Latin America and the Caribbean has a unique landscape of natural laboratories that can provide comparative advantages to host the development of RI’s, as well as high impact science on specific thematic areas that are a priority in both regions. It has been deemed necessary to increase the visibility of both EU and LAC RI models and characteristics to advance in a greater collaboration for a common roadmapping exercise, agreements in long term funding, transnational access, capacity building and mutual openness for the development of a RIs common area. EU-LAC ResInfra Plus has brought together a wide and comprehensive consortium of 20 crucial partners from the EU and LAC countries. The project includes a balanced mix of governmental representatives responsible of the development of RIs policies at national level, RTD funding agencies from EU countries (Finland, Germany, Italy, Portugal, Romania, and Spain) and LAC countries (Argentina, Brazil, Colombia, Costa Rica, Cuba, Chile, Peru and Uruguay,) as well as a consolidated group of European RIs: Instruct-ERIC, LifeWatch-ERIC, RICAP and MIRRI-ERIC. This broad spectrum of partners gat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Post-transcriptional networks regulating organ-specific and general infection mechanisms in the rice blast fungus' (RICEBLAST-NETWORKS).

assistant: **Concept**

The rice blast fungus M. oryzae has emerged as a paradigm for the understanding of fungal aerial attack.  M. oryzae also infect roots.  Consequently, M. oryzae-rice interaction represents an excellent pathosystem for comparative studies of the distinct organ-specific mechanisms that occur during fungal colonisation of rice leaves and roots. We have characterised two pathogenicity-deficient mutants in M. oryzae lacking the karyopherin Msn5p/EXP5 [Plant Cell 22, 953 (2010)] and a novel RNA-binding protein (RBP35) present exclusively in filamentous fungi [PLoS Pathogens, under review]. This project aims to investigate both organ-specific and pos-transcriptional mechanisms that regulate the ability of M. oryzae to infect rice using the resources generated previously in my group. The work outlined in this proposal will extend this area of research through:1. Deep sequencing experiments using infected rice leaves and roots with a wild-type M. oryzae strain to follow changes in gene expression in the fungus and in the host plant.2. Tandem affinity purification experiments using EXP5-tagged with HA-FLAG to identify proteins and RNAs that directly interact with EXP5.3. Tandem affinity purification experiments using highly conserved proteins of the M. oryzae polyadenylation machinery to identify additional protein components and use a combination of SELEX and bioinformatic approaches to discover alternative polyadenylation signals in M. oryzae genes.4. In vivo visualisation of infection-related mRNAs including fungal effectors using the lambdaN/GFP system to analyse the involvement of RBP35 in mRNA transport and/or localisation.At present there is a lack of knowledge of the EXP5 cargoes in filamentous fungi and very little is known about the post-transcriptional mechanisms that r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural proteomics in Europe' (SPINE), addressing dissemination and exploitation.

assistant: **Impact**

The project assembles most European laboratories that are involved in or are initiating structural genomic programs. The research component covers the expertise necessary for developing appropriate tools and methodologies. Using these technologies, genomic data will be exploited to achieve high quality, high throughput determination of 3D protein structures to shed light on biomolecular mechanisms relevant to human health. The targets are from a set pathogenic bacteria and viruses, as well as biomedically relevant human proteins (with a focus on cancer and neurobiology). The project is science-driven since the best way to foster technological progress is through the solution of challenging biological problems. Networking will channel synergistic collaborations between national programmes and disseminate information and technologies Europe-wide. The Training & Mobility component builds on existing strengths to ensure exposure of young European scientists to cutting edge developments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Modular fluidic platform with Shape Memory Alloy miniature valves to disrupt medical technology industry (memetis)' in the context of a Horizon 2020 call.

assistant: **Objectives**

memetis is an award-winning innovative SME, spin-off from Institute of Microstructure Technology (IMT) / Karlsruhe Institute of Technology (KIT) that designs modular fluidic platforms using Shape Memory Alloy (SMA) miniature valves for user specific needs. It enables the realization of unprecedented fluidic platforms in terms of outer dimensions, functionality, integration density and power consumption. Uses of the technology range from laboratory based tools to commercial applications like medical diagnostics.Processes which are normally carried out in a lab can be miniaturized on a single chip and performed at the Point of Care/ Point of Need to enhance analysis, diagnostic efficiency and speed while reducing sample and reagent volumes. At the intersection of engineering, physics, chemistry, information technology, and biotechnology, memetis can revolutionize the way patients are diagnosed, monitored and treated. This solution has high disruptive potential and can be implemented across Europe and beyond to reach a large worldwide market.Prototypes of various SMA miniature valves are already available. In the past year several pilot customers acquired paid developments and application-specific projects were transferred to series production (30,000 – 50,000 pieces). Currently, incoming 2018 orders are of low 6-digits providing a solid basis to achieve this year's turnover objective.Our traction has already been substantial. Besides the EXIST Research Transfer Phase I grant, we have attracted equity investments and we have received the following awards: 1st place KIT Venture Fest Gründerpitch (Aug 2016), 1st place Elevator Pitch Baden-Württemberg (Jun 2017), Winner WECONOMY (Jun 2017), Init Innovation Prize Cyber Champions Award (Aug 2017), 2nd place CyberOne Hightech Aw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bayesian Truth Serum and its applications to conjoint analysis: a reliable way to assess user preferences for new products, services and policies' (BayInno).

assistant: **Innovation**

Many areas of economics use subjective data. In use of subjective data the crucial question is how much confidence one can have in truthfulness of respondents' answers. Resolving this problem would improve reliability of current uses of subjective data and also open up new possibilities of use. One solution to this problem is presented by Bayesian Truth serum (BTS). BTS is a game-theoretic scoring system that takes as inputs respondents’ answers to questions, as well as their probabilistic predictions about the distribution of answers in the sample. It induces truthful answers from a sample of rational, i.e. Bayesian, expected value maximizing respondents. The method allows for collecting data on issues that are not common knowledge of neither respondents nor experimenters. In particular, BTS can be applied to judgments involving counter-factual or conditional scenarios, such as arise naturally in policy discussions. BTS is a very new methodology that is currently being experimentally validated through a large scale project IARPA RFI-10-01 at MIT, starting from 2011. The BTS method offers various opportunities for application to economic and social sciences. This project proposes to apply the BTS method to innovation research by making adaptations to the BTS so it can be embedded in the conjoint analysis. Conjoint analysis is a methodology widely used across industries and in public sector for preference elicitation related to new products, services or policies. Conjoint analysis allows for designing products/services/policies with the ideal combination of features thus increasing probability of successful introduction. As all methods that use primary data collected through surveys, conjoint analysis crucially depends on the truthfulness of the subjective data. BTS in t