RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Leukemic Stem Cells in Chronic Lymphocytic Leukemia' (2007-2013).

assistant: **Innovation**

B cell Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in western countries. Although substantial therapeutic improvements have been obtained, the disease is incurable and causes 4000 deaths/year in the sole USA.We plan to in vivo evaluate CLL B cells division by measuring Deuterium (2H) incorporation into newly synthesized DNA. 2H given to patients in the form of deuterated water (2H2O) is a very practical, safe, non invasive approach that has been already exploited in CLL patients.Preliminary data obtained in 15 CLL patients using the 2H labeling approach are showing  in each CLL clone two sub-populations that have 10 times different proliferation rates and can be identified using two well known surface markers, CXCR4 and CD5. The data also indicate that isolated resting cells express higher mRNA for genes found in hematopoietic stem cells (HSC) such as ABCB1, ABCB4 and Notch1. On the other hand proliferating cells express higher levels of known activation markers some of which (CD38, CD52, CD23, others) are target of monoclonal antibodies already in use.We want to refine the description of proliferating and resting cells within each clone by running a more extended immunophenotype and gene expression profile. The detailed description of highly resting and highly proliferating cells will provide new insights of the biology of the disease and a powerful tool for developing drugs aimed at target these fractions with high specificity.Moreover, RAG2-/-yc-/- mice will be used to test if highly defined resting and proliferating cells differ in their capacity to recapitulate the tumor. This mouse background has been successfully used for reconstituting a human hematopoietic system by transferring CD34+ cells and was found to support with high efficiency expans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular Theory of Drug Intercalation into DNA' (MTDI-DNA) under Sixth Framework.

assistant: **Objectives**

The interaction between aromatic ligands (e.g. daunomycin) and deoxyribonucleic acid (DNA) has been the object of considerable research in connection with the use of such molecules as anti-cancer drugs. Drug design usually aims to exploit the specificity of gene sequence in the cell DNA, since diseases are often connected with gene defects.   The action of the ligand (i.e. drug) has been interpreted as an intercalation into the DNA structure with some unknown binding mechanism lengthening the helix. To the best of our knowledge a microscopic interpretation of the mechanism and rate based on the dynamics of the ligand-DNA interactions is still lacking. We thus propose a complete theoretical investigation of the mechanism of the intercalation which considers the effects of the molecular nature of the drug and of the portion of DNA exposed to the ligand action.  The goal of this research is to provide a molecular understanding of and a predictive theory for rational improvement of drug design. In addition to the value of the project in the biomedical field and therefore in the development of European research concerning anti-cancer drugs, an advanced training in multi-disciplinary subjects will be necessarily provided to the fellow in her chosen field of future research. Intercalation is in fact a complex process involving the motion of the ligand and the local DNA structure (which must change to accommodate the drug) and rearrangement of surrounding solvent and ion molecules.   A multi-dimensional free energy surface, constructed via electronic structure calculations and Molecular Dynamics computer simulations, and a generalized Langevin description approach will be employed to analyze the dynamics of the motion leading to the binding and to construct an explicit theory f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NExt level Quantum information processing for Science and Technology' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Quantum computers are extremely promising emerging technologies with inter-disciplinary teams around the globe working on their development and implementation. Yet, progress is hampered by fundamental difficulties in scalability, end-user friendliness, certification of components and algorithms, and limited application scope to real-world problems. To overcome these urgent challenges, NeQST leverages an extended quantum information processing paradigm based on multi-level carriers of quantum information—qudits.  Both the quantum hardware at the fundamental level, and many problems of scientific and technological relevance, are expressed in terms of multi-level systems, making this approach the most efficient choice to unlock the full potential of quantum computers and simulators.NeQST will generate foundational breakthroughs in the full value chain of qudit quantum information processing. These include qudit based firmware with scalable characterization and automatized design tools harnessing a larger Hilbert space; an end-user friendly high-level control and simulation software, enabling non-specialists to utilize the qudit hardware; the efficient simulation of quantum models of scientific relevance, such as gauge theories; the solution of optimization problems in academia and industry naturally phrased in terms of multi-level variables; and certification tools specifically designed for multi-level quantum information, enabling a device-independent validation of data. NeQST results will therefore elucidate the role of dimension in quantum physics and its use as a resource for quantum information processing.To achieve its ambitious goals, NeQST has assembled an inter-disciplinary team of leading academic and industry partners, and has developed a well-rounded work plan,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Generating artificial touch: from the contribution of single tactile afferents to the encoding of complex percepts, and their implications for clinical innovation' (ARTTOUCH).

assistant: **Innovation**

Somatosensation encompass a wide range of processes, from feeling touch to temperature, as well as experiencing pleasure and pain. When afferent inputs are degraded or removed, such as in neuropathies or amputation, exploring the world becomes extremely difficult. Chronic pain is a major health issue that greatly diminishes quality of life and is one of the most disabling and costly conditions in Europe. The loss of a body part is common due to accidents, tumours, or peripheral diseases, and it has instantaneous effects on somatosensory functioning. Treating such disorders entails detailed knowledge about how somatosensory signals are encoded. Understanding these processes will enable the restoration of healthy function, such as providing real-time, naturalistic feedback in prostheses. To date, no prosthesis currently provides long-term sensory feedback, yet accomplishing this will lead to great quality of life improvements. The present proposal aims to uncover how basic tactile processes are encoded and represented centrally, as well as how more complex somatosensation is generated (e.g. wetness, pleasantness). Novel investigations will be conducted in humans to probe these mechanisms, including peripheral in vivo recording (microneurography) and neural stimulation, combined with advanced brain imaging and behavioural experiments. Preliminary work has shown the feasibility of the approach, where it is possible to visualise the activation of single mechanoreceptive afferents in the human brain. The multi-disciplinary approach unites detailed, high-resolution, functional investigations with actual sensations generated. The results will elucidate how basic and complex somatosensory processes are encoded, providing insights into the recovery of such signals. The knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Networking in Candidate countries towards Food, GI-tract functionality and human health' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

This measure will provide a valuable accompaniment to European research area in the field of Food, Gl-tract functionality and human health by expanding challenging forums to Candidate countries for conveying the objectives and outcomes of EU research projects. The proposal action covers all areas of integrating and strengthening the European research area. It helps the Candidate countries researcher, new businesses and research organisations to have access to the knowledge and expertise existing elsewhere in the world. The action contributes to European research area Food Quality and Safety, Area 5.4.3 Impact of food on health. The action will invest in dissemination of the results of ongoing Food and Health ED research with special reference to EU cluster and piloting and expansion of future expanded networks. The expected achievements of this GUTHEALTH support action are summarised as: ? Six (6) roadshow workshops in Candidate countries with an innovative and challenging format to disseminate to targeted scientific and industrial audiences the objectives and outcomes of European research projects relating to food, intestinal microbiota and human health. Industry will be involved to show how these innovations can and have been translated into products accessible to consumers. ? Courses providing education for young or senior scientists and technology transfer of innovations produced in the ongoing EU projects on gut health and knowledge sharing of new methods, tools and applications towards health benefits. ? Invitations to coming conferences (2004, 2005, 2006) for Candidate countries scientists establishing networks and scientific co-operation and information flow between the Candidate countries and different research projects within the Food and Health area ? The eve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Central asia and the european union: international conference on ticks and tick-borne diseases' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The proposed conference will focus on ticks and tick-borne disease (TBD) situation in Central Asia, which causes an enormous economical loss of dairy cattle and small ruminant production. Altogether 25 participants will attend the meeting in Tashkent, Uzbekistan, Central Asia: 15 from Central Asia, 5 from Europe, 5 from neighbouring countries (China, Indian and Middle East). The meeting comprises plenary sections, oral presentations and working groups. Invited speakers with outstanding reputation in the field of epidemiology, economics, diagnostics, vaccination and integrated control of ticks and tick-borne diseases will provide the conference with the state of art in each field. Through oral presentations recent observations and results will be presented. Working groups will be formed to establish and identify future research directions, elaborate the creation of regional collaborations and evaluate cost-effective vaccine production and diagnostics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pioneers of europe's integration 'from below': mobility and the emergence of europe identity among national and foreign citizens in the eu' (PIONEUR).

assistant: **Concept**

A widely held view, re-asserted in several EU documents, is that the mobility of citizens within the EU encourages the sharing of cultures and promotes the concept of European citizenship as well as that of a political Europe". Since the Treaty of Rome, therefore, a higher movement of individuals among member states has been favoured. Nonetheless cross-country mobility remains very low and its expected virtuous effects on European integration a matter of mere speculation. To understand why mobility is so low, the project focuses on those few Europeans who do move, seeking to answer some basic questions through empirical multimethod analysis at the individual level: Do people who move really contribute to further European integration? What are the implications of mobility for the quality of life of the persons and families involved? In which regard do ' internal movers ' from member states differ from 'external movers' from candidate countries migrated to the EU?"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dive into Science' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The Researchers' Night 2006" that will take place on the 22nd of September will materialize in Galicia in the project "Dive into Science" (DIS). In the line of the "Researchers' Night", the main goal of DIS is to submerge people and researchers in a festive atmosphere where research shows its funniest face.To achieve this objective, the activities proposed will be held in a typical coastal environment: a fish market, a traditional schooner, diving pools, etc. The objectives of the project are:- Show research as an attractive activity that is within anybody's reach. Public will be able to enjoy water sports like diving that are also used to make research. They will have the opportunity to participate in contests and games related to science and enjoy the artistic side of science through music, photography and fireworks.- Show that scientists are "normal" people. Researchers will take active part in the activities as peer fellows with the public and they will chat with the public. The scientists will also show other skills different from those related to science. In the three cities, researchers and public will mingle during cocktails, role games, on board parties and food-tasting events, etc.- Multipliying effect. This first edition of the 'Researchers ' Night' in Galicia will pave the way for further awareness events in the region with the researcher's direct involvement. To optimize the resources and obtain the maximum impact from the initiative, activities will take place in the three most representative Galician cities for the maritime sector: Vigo, A Coruña and Celeiro. Researchers from both public and private entities will participate in the project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'An intuitive entrepreneurial gender ceiling and its impact on entrepreneurial success and access to finance'.

assistant: **Concept**

Despite the growing number of female-led firms in Europe, such entrepreneurial ventures tend to be smaller in size, have more limited access to finance, and show slower growth and lower profits than male-owned businesses. Because of the nature of entrepreneurship, it is postulated, in line with emotions-as-information theory, that intuition affects decision-making. How intuition affects profits and growth of female and male ventures as well as access to finance, which are crucial for survival, has not to date been objectively investigated.Applying the social-psychology theory of the stereotype content model, ROLLER-COASTER’s aim is to investigate entrepreneurs’ and venture capitalists’ (VCs) intuition and its impact on success.Three research objectives are targeted:1) to create a solid interdisciplinary framework2) to explore the ‘entrepreneurial gender ceiling’3) to enhance related theories and conceptsTwo study phases focus on achieving the objectives:Study 1: Does intuition among entrepreneurs facilitate profit and growth similarly for men and women?Based on Orbis data, self-reports and biophysiological, and behavioral data relating to at least 200 entrepreneurs of both sexes, it is proposed to analyze if female entrepreneurs show higher attributions to intuition but use it less effectively in realizing firm profit and growth than males do.Study 2: Does VCs’ intuition influence investment decision preferences in either female- or male-led ventures?Based on Study 1, pitches will be produced with switched genders and shown to at least 200 VCs to explore whether VCs with high attributions and use of intuition are more likely to invest in male than in female ventures.ROLLER-COASTER will support European educators and policy-makers as they develop instruments to support e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent and Customized Tooling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Intelligent and Customized Tooling (IC2) addresses the need for new technology and organizational models for the tooling industry. By developing a technological foundation and organizational models for intelligent tooling systems customized for user’s needs, the European tooling industry can increase competitiveness trough knowledge intensive tooling and increased customer value. IC2 will be a multidisciplinary research with hybrid manufacturing, coatings and tribology control, surface embedded sensors and new organizational models. IC2 will combine state-of-the-art additive and subtractive processes into a hybrid manufacturing cell. Such a cell will typically integrate the precision and performance of high-speed milling, grinding and/or polishing with the geometrical freedom of Additive Manufacturing Technology for the production of tooling inserts, cores, channels and cavities. Advanced coating technologies will be used to create intelligent surfaces featuring embedded sensors, high wear resistance and excellent friction properties control. These new technologies utilized trough new organizational models will allow the tool-ing industry to be more versatile and demand driven with symbiotic relations to the tool users. IC2 will have a large SME participation and substantial demonstrator activates in addition to cutting edge RTD activities. The results of IC2 is expected to be a new concept for Knowledge Intensive Tooling for the benefit of European manufacturing competiveness. The impact of IC2 knowledge intensive tooling will be substantial reduced time-to-marked, process tact times and tooling/manufacturing costs. The new technology enables new business models with full tool life cycle service and enhanced high value tools for the manufacturing industry. The Hybrid m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unifying the European experience: historical lessons of Pan-European development' (UEE) targeting Sixth Framework.

assistant: **Abstract**

The network will contribute to the development of a truly European economic history profession, by analysing the economic development of Europe as a whole. The network will collect pan-European data for two time-scales, the long run (i.e. the past 150 year s), and the very long run (i.e. the past 1000 years). It will use up-to-date economic techniques, both theoretical and econometric, to analyse these data and provide accounts of European growth, European economic integration, and the changing nature of Eu rope¿s economic relationships with the rest of the world, in the long run and very long run. Core training objectives of the network include: 1) the development of a more quantitatively sophisticated approach to analysing historical data; 2) the promotion of pan-European and comparative economic history; 3) the development of a more `presentist¿, policy-relevant, economic history profession in Europe. Economic history is an interdisciplinary enterprise that requires young researchers to acquire a range o f quite different skills. Careful archival research, is necessary when constructing new databases and thinking sensitively about the evolution of the institutional framework. The tools of the economist are also required when analysing data, or when theoris ing about causal relationships between various variables. When analysing the evolution of policy economic historians interact with political scientists; whilst a consideration of the institutional framework brings contact with lawyers and legal historians , and an understanding of the wider social context requires contact with sociologists and social historians. This network will concentrate on the boundaries between economics and history but be sensitive to the wider inter-disciplinary agenda.