RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'New Materials for High Moment Poles and Shields'.

assistant: **Innovation**

The ever-expanding demand of the world market leads to magnetic recording data storage devices advancing toward much smaller dimensions and higher storage capacities. In order to achieve capacities beyond 2TB/in2 next generation magnetic recording head transducers will require improved high moment magnetic material together with novel write pole and shield structures to preserve the necessary magnetic flux on reduced device dimensions. The implementation of novel high moment magnetic materials and design in manufactured products requires the attainment of new knowledge by the magnetics industry along with the response of the academic industry to the new performance challenges. These goals can only be reached through a strong collaborative programme between industry and academia. The scientific programme is to study the properties of magnetic materials to enable higher moment than the presently attainable limits. Nanoscale engineering of magnetic thin films will be the main approach to achieve this. The knowledge will be transferred through the cross-border secondment of staff and researchers between Seagate, Duisburg-Essen and Uppsala, utilizing the complementary expertise of the three nodes regarding state-of-the-art experimental and computational techniques as well as device fabrication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fiscal capacity and warfare in Europe and Latin America in the long nineteenth century (1789-1913).', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project seeks to contribute to understanding the impact of warfare on the expansion of fiscal capacity in the long nineteenth century (1789-1913) in Europe and Latin America. The relationship between late-modern warfare and fiscal institutions has been a contested issue. Even though wars may exert a negative short-time impact on public revenues due to the physical destruction that they cause, several authors have suggested that over the long run they may promote fiscal innovations that improve the government’s capacity to collect taxes. However, our knowledge about state-making and the rise of fiscal capacity in late modern times is still insufficient. To begin with, much more emphasis should be placed in the effects exerted by limited and civil wars. Unlike mass warfare, limited and civil wars do not necessarily trigger the social and political changes associated to permanent increases of public revenues. Secondly, the interaction between warfare and economic and political factors still remains open to question. In order to address these unresolved issues, the project aims at making use of a mixed-methods approach that brings together quantitative and qualitative techniques. Firstly, I seek to conduct statistical analyses of large N-samples by means of collecting new long-term annual series of public revenues and expenditure. While the lack of data has been an unavoidable setback for previous analyses, recent new datasets are closing this gap (including the one that I elaborated during my PhD program, as well the databases elaborated by members of the STANCE project at Lund University). Secondly, I seek to narrow down the analysis to focus on several case studies in Europe and Latin America. The qualitative analysis of these specific case studies will help the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Defining the role of Arp2/3 complex diversity at multiple scales of biology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2/3 complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. The Way lab has shown that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks. The Way and Gomes labs have shown how specific Arp2/3 isoforms are essential for muscle development.Our synergistic, high-risk, high-gain goal is to define the role of Arp2/3 complex diversity at three hierarchies of biology:1. Molecular basis of Arp2/3 diversificationWith purified isoform-specific complexes we will perform cryo-electron microscopy and single molecule fluorescence microscopy to reveal the structural variations and influence of Arp2/3 diversity on actin networks in vitro.2. Cellular function of different Arp2/3 complexesWith cells expressing specific Arp2/3 isoforms, we will use quantitative live cell imaging and cryoelectron tomography to reveal the dependence of cellular actin networks on Arp2/3 diversity and its functional consequences.3. Developmental and physiological role of individual Arp2/3 complexes. With genetically modified cultured myofibers and transgenic mice, we will use an array of imaging approaches to reveal the contribution of different Arp2/3 family members to muscle development, structure and physiology.Our interdisciplinary plan builds on the strengths of our three labs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GaN densily integrated with Si-CMOS for reliable, cost effective high frequency power delivery systems' (GaNonCMOS).

assistant: **Innovation**

Power electronics is the key technology to control the flow of electrical energy between source and load for a wide variety of applications from the GWs in energy transmission lines, the  MWs in datacenters that power the internet to the mWs in mobile phones. Wide band gap semiconductors such as GaN use their capability to operate at higher voltages, temperatures, and switching frequencies with greater efficiencies. The GaNonCMOS project aims to bring GaN power electronic materials, devices and systems to the next level of maturity by providing the most densely integrated materials to date. This development will drive a new generation of densely integrated power electronics and pave the way toward low cost, highly reliable systems for energy intensive applications. This will be realized by integrating GaN power switches with CMOS drivers densely together using different integration schemes from the package level up to the chip level including wafer bonding between GaN on Si(111) and CMOS on Si (100) wafers. This requires the optimization of the GaN materials stack and device layout to enable fabrication of normally-off devices for such low temperature integration processes (max 400oC). In addition, new soft magnetic core materials reaching switching frequencies up to 200 Mhz with ultralow power losses will be developed. This will be assembled with new materials and methods for miniaturised packages to allow GaN devices, modules and systems to operate under maximum speed and energy efficiency. A special focus is on the long term reliability improvements over the full value chain of materials, devices, modules and systems. This is enabled by the choice of consortium partners that cover the entire value chain from universities, research centers, SME’s, large industries and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fate of sulfonamides in wetland systems by multi-element stable isotope concept' (FATE-SA) targeting Horizon Europe.

assistant: **Abstract**

Antibiotics (AB), their degradation products and the translocation of resistant genes in the environment poses serious health risks to humans, animals and ecosystems (OneHealth concept). Constructed wetlands (CW) have untapped potential to treat wastewater from agriculture, domestic sewage or contaminated water effluents from waste water treatment plant for eliminating AB. However, the overall distribution, persistence and the contribution of different dissipation processes of AB in CW remain mostly unknown. Here, the project aims to identify degradation processes of AB in wetlands by developing a cutting-edge four-dimensional element isotope (13C, 15N, 2H, and 33/34S) approach and concepts to improve CW use worldwide. Sulfonamides (SAs) are selected as representative AB. Methods of isotope-effect free extraction from environmental matrices and isotope analysis will be developed while a conceptual framework will be tested to isotopically identify degradation processes in wetland, including the direct and indirect photolysis with DOM and nitrate and plant degradation in vitro and in vivo, and to further monitor SAs degradation in the field using isotope concepts. This work will open a new paradigm to better understand and follow up the fate of SAs and other emerging micropollutants in wetlands but also for other field conditions. The applicant has a proven record of experience of isotope concept application supported by 6 first authored publications and has developed independent thinking and problem-solving skills during his past scientific study. The host holds both unique infrastructure for stable isotope analysis (GC/EA-IRMS, MC-ICPMS) and the expertise for implementation, evaluation and interpretation and a rich experience for wetland field work. This project is thus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conscientious objection in the UK and Italy: a qualitative study of health providers’ perspectives on abortion' (CONOB) targeting Seventh Framework.

assistant: **Abstract**

A qualitative study of obstetricians-gynecologists’, residents’ and medical students’ experiences and attitudes towards conscientious objection and abortion is proposed in two European countries: one in Northern Europe - the UK, and the other in Southern Europe - Italy. The main objectives are to examine how conscientious objection is experienced by these physicians and by medical students and how it affects abortion training and provision in different clinical settings and geographical areas. The study will investigate how current and future obstetricians-gynecologists’ choices regarding training and providing abortions is influenced by: 1- their cultural and religious background and beliefs; 2- their professional training and experience (including  knowledge of abortion’s epidemiology, of  maternal morbidity and mortality, of the Ethical Code of Medicine and of the laws regarding abortion and their experience of abortion stigma); 3- their engagement with the political, scientific and religious debate on  reproductive health and rights. Conscientious objection is increasing both in the UK and in Italy, leading to a decrease in the number of abortion providers in public health services. It is not known whether and how conscientious objection is affecting other aspects of abortion services. Only a few quantitative studies on gynecologists’ experience and attitudes towards abortion have been undertaken in the UK, while no such studies have been undertaken in Italy. The present qualitative study will give an important contribution to the European scientific debate by providing new data on a topic which is relevant from an anthropological, public health and policy perspective. The Council of Europe (COE) is attempting to regulate the use of conscientious objection in Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tumor suppressive microRNAs for cancer therapy' (RxmiRcanceR).

assistant: **Innovation**

The challenge for cancer therapy involves hampering the mechanisms by which the normal gene expression machinery is taken over to allow the aberrant appearance of cancer driving genes. I propose exploiting the therapeutic potential of a special class of tumor microRNAs (miRs) that function as natural post-transcriptional tumor suppressive regulators of many genes in key pathways. These anti-cancer effectors represent an inherent organismal property that I propose to augment and thereby translate into a form of systemic anti-cancer therapy. First, focusing on hepatocellular carcinoma (HCC), I shall perform high throughput screening to identify preferred HCC tumor suppressive miRs. Second, I shall search for small molecules capable of elevating the level of those relevant miRs in tumor cells and tissues. Increasing miR expression will potentially also enhance their secretion into the circulation in exosomes thereby suppressing gene expression at remote tissue sites as well. Third, I shall test the potential of these miRs to better target and inhibit the growth of tumor cells both, in culture and in vivo. This unprecedented conceptual strategy should stimulate the organism’s self-healing potential by enhancing inherent anti-tumor mechanisms. This project is built on robust preliminary findings that show promiscuous anti-cancer effects and predictably fewer side effects due to its completely host-based nature, with the administered miR inducer being the only foreign element. Additionally, due to the fact that each miR simultaneously targets a number of molecular pathways as well as multiple steps within a given pathway, it could help to overcome the major problem of cancer therapy – resistance. This strategy of harnessing these efficient and robust miRs and exosomes for del
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SUstainable Preservation of Masonry Arch Bridges' (SUPMAB), addressing dissemination and exploitation.

assistant: **Impact**

SUSUPMAB project aims to develop, test, and validate a novel strategy for the sustainable management and preservation of masonry arch bridges (MABs) considering the unique features of these structures and their cultural heritage and social value. SUPMAB responds to the urgent need for cost-effective and sustainable techniques for extending the lifetime of MABs, many of which exhibit signs of distress. MABs are a vital part of transportation infrastructure and form part of our cultural heritage. Transport agencies and councils are facing significant challenges in managing and maintaining MABs. The limited funds allocated for risk management and mitigation mean that they need to correctly identify the structures more at risk to prioritize interventions. The increasing importance of environmental (i.e. climate change-related) considerations in the maintenance and renewal of infrastructure assets also means that factors such as energy and resource consumption and carbon emissions must be considered in addition to monetary costs in the decision-making process. Finally, the actions taken by bridge managers (e.g. closure, retrofit) must be soundly justified and accepted by the communities affected.SUPMAB aims to develop a novel multi-criteria framework for MAB risk management practice to aid decisions concerning the inspection, assessment, monitoring, operation and repair/strengthening of these structures. Based on Bayesian decision theory, the proposed framework considers several overlooked attributes of enhanced condition assessments, such as modelling/analysis sophistication and knowledge/information content, and environmental and social indicators in addition to economical ones, to define optimal management and maintenance strategies for MABs. The proposed framework can ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Single molecule studies of DNA Polymerases using Fluorescence Microscopy and laser tweezers. A step towards the combination of these techniques' (FRETANDFORCE) targeting Sixth Framework.

assistant: **Abstract**

Single molecule methods have shed light on many important biochemical phenomena: optical tweezers has contributed important mechanical information about molecular motors, while single molecule imaging techniques have been used to explore the diversity of behaviour of biological molecules which is often masked by ensemble measurements.The central enzyme in the DNA replication process is DNA polymerase, a particularly interesting enzyme responsible for duplicating our genetic information, making less than one mistake in a billion bases. One goal of this research proposal is to develop a method of studying the complex kinetics of DNA polymerase at the single molecule level, using fluorescence microscopy and fluorescently labelled nucleotides.DNA polymerase can be considered a molecular motor since it moves along a DNA track while using energy. Laser tweezers can probe biological systems as a function of force. By studying the enzyme reaction as a function of force, information about the energy release can be obtained.We propose experimental configurations whereby DNA polymerase is immobilized on a solid surface, allowing direct measurement of the interaction forces. Also the coupling of single-molecule manipulation with single-molecule fluorescence opens up many possibilities for observing spectroscopic signals in response to mechanically induced changes in biological macromolecules.This is an ambitious project that initially will allow us to correlate conformational changes and displacement with polymerization or digestion of DNA polymerase The Work Programme contains a series of specific objectives, the augmentative goal of which is to direct attention and funding towards the long-term reinforcement of European science and technology.The interdisciplinary nature of the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The causes of hyperglycaemia in the face of rising obesity' (GLUCOSEGENES).

assistant: **Concept**

The aim of this proposal is to make a major advance in understanding why some people develop diabetes despite relative leanness and why others maintain normal glucose levels despite obesity. My vision is that human genetics and the ability to study humans will provide a major leap in understanding disease mechanisms. We will use state of the art resources in genomics, metabolomics, and large human biobanks to study three stages in life that may influence predisposition to diabetes independently of obesity:in utero life: We will test the hypothesis that the in utero environment alters offspring glucose levels and metabolism. We will perform the most comprehensive analyses of the in utero environment using mass-spectrometry based metabolomics. We will use maternal genetic factors that influence glucose levels in pregnancy to test the causal effects of the in utero environment on offspring outcomes.“long-term” life: We will test the hypothesis that long-term exposure to altered metabolic and circulating factors influences glycaemia and metabolism. We will use the principle of Mendelian randomization to identify the subset of known and novel biomarkers that are likely to play a causal role in diabetes disease processes.“Pre-diabetes” life: We will test the hypothesis that non-diabetic individuals carrying different type 2 diabetes genetic risk factors will have different physiological characteristics. Little is known about the detailed physiology of individuals carrying the greatest number of genetic risk factors. We will perform detailed physiological studies in non-diabetic individuals predisposed to type 2 diabetes based on specific genetic risk factors. These characteristics may inform intervention and treatment strategies targeted at those at greatest genetic risk of d