RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-Payload satellite as an innovative service for technology experimentation in space' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project objective is to provide a low-cost and fast service for test and evaluation of technology devices in outer space. The most outstanding added value of this proposal is to bring the space sector closer to technology developers through the standardization of the payload integration. The rate of production of new components and technologies in the European space industry is currently not accomplished to the availability of opportunities for in-orbit testing. European space industry needs to increase rapidly the maturity level of these components, in order not to lose the leading position in terms of technological competitiveness and innovation. This situation brings the commercial opportunity for a low cost and time effective service to evaluate new technologies in space environment, providing a multiple payload integration service to gain heritage as fast as the industry is demanding at present.This innovative business opportunity, called Multi-Payload Satellite (MPSAT), is focused on achieving a new concept of space mission based on small satellites for in-orbit demonstration. The proposed project will develop a feasible and flexible service, drastically increasing the availability of opportunities for in-orbit testing for the whole technology developers’ community. The proposal concept mimics a previous successful initiative known as Multi-project Chip Wafer (MPW). MPW is a foundry service in microelectronics, where the share of the non-recurrent costs involved in the manufacturing of several integrated circuits on a single run drastically reduces its price. In this way, MPSAT service offers flight opportunities to the technology developers without resources for managing their own mission, offering dedicated payload slots and including all the mission steps a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Paradigm shift from kidney biopsies to advanced molecular diagnostics from patient urine'.

assistant: **Concept**

BACKGROUND: Proteinuria is a sign of kidney involvement in association with common infectious, inflammatory, immunological or metabolic (diabetes) diseases. When persisting, proteinuria leads to scarring and end-stage kidney disease requiring dialysis or renal transplantation. Both treatments are chronically debilitating, increase risk for severe secondary complications and are extremely expensive. Altogether, kidney complicationsconstitute more than 15% of total health-care costs in most Western countries, mainly due to increasing prevalence of diabetes-associated kidney disease.PROBLEM: Earlier diagnostics is urgently needed to target intensive treatment efforts and to avoid the projectedexplosive increase in the number of kidney patients in near future. Due to the demographic trends, kidney diseases are a particular problem for Europe. At present, the diagnostics include serum markers (mostly non- sensitive, non-specific) and urine analysis (too late markers) but relies mainly on patient kidney biopsy samples. Although accurate, this procedure is severely inconvenient, invasive and carries a notable risk for complications.SOLUTION: We propose to use the latest molecular information of verified pathogenetic routes, proprietary bio informatics platforms, well established in vivo models as well as extensive human sample repositories together with the SME activities to establish and validate new diagnostics. This includes the identification of an expanding set of key molecular markers directly from patient urine to yield novel measurable for early and accurate non-invasive diagnostics. With the set of markers accurately reflecting pathophysiologic changes we expect to replace the traditional kidney biopsies with more patient-friendly, accurate and economical diagnostics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A COmprehensive cyber-intelligence framework for resilient coLLABorative manufacturing Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Industrial automation is expanding at an increasing pace, where this surge of innovation is driven by recent advances in information and communication technologies facilitating a “phase transition” towards “Industry 4.0”. Coupling Industrial Internet of Things (IIoT) with Big Data analytics and Artificial Intelligence (AI) in industrial automation context is what will make industrial systems intelligent, enabling them to exchange information and operate remotely. However, the vision of future intelligent and autonomous manufacturing units is counterbalanced by exponential increase in security risks and attack surfaces that emerge as the production systems grow ever more connected. The manufacturing ecosystem lacks a thorough cyber intelligence solution that addresses the key IIoT-related cybersecurity challenges towards a full realization of collaborative manufacturing in the context of Industry 4.0.COLLABS will develop, validate, demonstrate, and support a comprehensive cyber-intelligence framework for collaborative manufacturing, which enables secure data exchange across the digital supply chain while providing high degree of resilience, reliability, accountability and trustworthiness, and addressing threat prevention, detection, mitigation, and real-time response. COLLABS will achieve these goals by utilizing state-of-the-art technologies and making significant scientific and technological advances in several key relevant domains, including secure multi-party computation and homomorphic encryption, distributed deep learning and anomaly detection, distributed ledger technologies (blockchain) and smart contracts, and distributed remote software attestation. COLLABS will significantly contribute to realizing industrial and societal opportunities of collaborative manufac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beauveriolide-Derived Cyclodepsipeptides as a New Class of Anti Alzheimer’s Drugs' in the context of a Seventh Framework call.

assistant: **Objectives**

The pathogenic event common to all forms of Alzheimer’s disease (AD) is the abnormal accumulation of the amyloid β-peptide (Aβ) in specific regions of the brain. This accumulation of Aβ is considered a key pathological event in AD and is the basis of the so-called amyloid hypothesis of the disease. Therefore, therapeutic approaches that reduce the accumulation of Aβ are currently being sought. It has been shown definitively that the generation and clearance of Aβ in the brain is regulated by cholesterol levels. Compounds that perturb free cholesterol such as acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitors have been shown both in vitro and in vivo to reduce Aβ production and secretion. However, it is generally the case that ACAT inhibitors exhibit poor oral activity. The beauveriolides are a new class of fungal metabolites that have been shown to be orally active ACAT inhibitors and are currently being investigated as potential therapeutics for atherosclerosis. NB No studies have been reported to date on the investigation of the Aβ-inhibitory effect of the natural product beauveriolides or beauveriolide-inspired compounds. Therefore, the hypothesis being tested in this proposal is that natural product beauveriolides or beauveriolide-inspired libraries of compounds should reduce Aβ-production and secretion in vitro via inhibition of ACAT and hence perturbation of cholesterol homeostasis. They would in such a case be a NEW CLASS of potential AD therapeutics working via an established mechanism of action and hence this proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'All in One: Harvesting of waste heat with solid thermal battery' (Heat2Battery).

assistant: **Innovation**

Thermal batteries are devices that convert thermal energy without the need for a spatial temperature gradient, giving them anenormous potential advantage over competing methods. Despite its promise, thermal batteries are yet not suitable for practicalapplication as they were demonstrated only with liquid electrolytes, which severely restricts the operation temperature range toΔT<50 K and an electrochemical stability window to pair with thermodynamically efficient electrodes. The goal is to develop acompletely new paradigm towards all-solid-state thermal battery (thermal cell), which is based on reversible changes of the materials’electrochemical properties and on H+ transport operating on recovered waste heat over an unusual wide range of temperatures ofambient to 300°C. We envision the solid thermal battery to charge at a defined low and high constant temperature due to phasechanges and H+ intercalation taking place at the electrodes. Fundamentally, we contribute to a new thermal battery concept, suggestmaterials to translate the proposed chemistry-at-work and give a proof-of-concept to gain first electrochemical performance insightsdefining thin film device architectures. Collectively, the here proposed solid thermal battery closes the ever-existing gap betweenthermoelectric and liquid based thermal batteries through widening of the thermal operation window to capture waste heat anddefining a new set of H+ solid conductors and interfaces suited for energy storage. The fundamentals derived on electrochemicalinterfaces and H+ conductor films such as ceria-based, metal hydride, binary oxide and possibly high entropy alloys for electrolytesand electrodes contribute in their design and careful discussion of electro-thermo-chemistry, thermodynamics and kinetics toengineerin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mdo 2000' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The next International Symposium on Microsomes and Drug Oxidations (MDO) will take place in Stresa-Lake Maggiore, Italy, from the 10th to the 14th July of the year 2000. This Symposium, the 13th in the series of MDO Symposia that are held biannually on the same topic, represents the major international meeting in the field of drug oxidations. It deals with genetic and environmental factors that affect in man both the therapeutic efficacy of drugs and the adverse reactions caused by drugs and other exogenous chemical agents. Approximately 700 delegates are expected to attend from the majority of the European Countries and also from the United States, Australia, Canada and Japan. Some of the most important scientists in the field have agreed to participate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intraspecific Variability in How Herbivores Cope with Induced Plant Defences' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Herbivore feeding induces massive metabolic reconfigurations in plants under attack. Such changes mediate tissue repair, resource allocation and defence. Induced plant-defences are studied intensively since they are plant-own and thus might lead to novel and environment-friendly ways of crop protection. Induced plant-defences come in two forms: the first are the induced direct defences which involve plant-produced toxins. The second are the indirect defences which augment direct defences and are established by de novo production of herbivore-induced plant volatiles (HIPV) that attract natural enemies of herbivores. Both types of defence decrease herbivore fecundity and survival. Thus, plant defences must impose selection pressure on herbivores and natural selection theory predicts that species will undergo adaptive changes towards increased resistance, provided there is sufficient genetic variation. Recently, such intraspecific variability was described for the first time in a herbivorous pest, the spider mite Tetranychus urticae. It was found that different individuals can induce or suppress direct defences and, importantly, differentially induce the emission of HIPV. Therefore mites may not only adapt to become resistant to plant defences, but also to not induce them and to not induce the attraction of natural enemies. I propose to characterize T. urticae selection-lines that differ in the extent to which they induce direct and indirect defences, and (1) to elucidate mechanisms whereby they hinder direct and indirect defences; (2) to map the inheritance of traits that enable mites to hinder defences, and (3) to investigate the implication of such traits for the stability and persistence of predator-prey meta-populations. Meeting these objectives will shed new light on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultrasonic scanning techniques for optimum imaging of coronary arterial disease' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

I Research objectives and content Ultrasonic catheter scanners prove valuable in fundamental studies of development of arterial disease and predict the treatment most appropriate for patients. However they are very limited in the way the scans can be performed. The inability to view in a forward direction also limits the use of Doppler blood flow techniques. The aim of this PhD project is to investigate the best scanning methods for forward viewing and 3D imaging with catheter scanners. This project will be undertaken with scaled-up tissue equivalent models of diseased arteries of say 50mm diameter which are suitable for imaging with 5MHz ultrasound transducers. This scaling up makes the construction of test devices very much easier than attempting to develop them on the true arterial scale. Training content (objective, benefit and expected impact) In this project the student would gain a detailed knowledge of medical imaging and in particular ultrasonic imaging which is a major diagnostic tool in routine clinical examinations and medical research. The student will also gain experience in medical image pro_ssing, digital electronics, research methods and clinical imaging as well as working with an research team of scientists and doctors. Links with industry / industrial relevance (22) No industrial links at present. However if successful, the results would be of industrial interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Comprehending Prokaryotic Argonaute Systems' (COMPASS).

assistant: **Innovation**

Eukaryotic Argonaute proteins are known for their central role in RNA interference pathways. Yet, the evolutionary origin of Argonaute proteins lies in prokaryotes, where other proteins essential for RNA interference are absent. Therefore, prokaryotic Argonaute proteins (pAgos) must have distinct ancestral functions. Although a handful of closely related pAgos interfere with exogenous DNA invaders such as plasmids, pAgos are extremely diverse in terms of sequence conservation and domain architecture. In addition, many pAgos genetically associate with various putative enzyme domains, which suggests that they are functionally interdependent. As such, different pAgos must rely on distinct mechanism and are expected to fulfil a range of different roles. Therefore, the function of most pAgos remains completely unknown. The COMPASS project will map the function of unexplored pAgo systems, in which pAgos associate with auxiliary proteins. I hypothesize that in these systems, pAgo binds exogenous DNA sequences in a guide-dependent manner. This can result in the recruitment and/or activation of the auxiliary proteins. As pAgo-associated auxiliary proteins are homologous to proteins involved in DNA recombination, NAD+ turnover, or protein deacetylation, these pAgo systems are expected to fulfil completely novel roles ranging from stimulating horizontal gene transfer to triggering programmed cell death. The uncharacterized roles of these pAgo systems and the mechanisms underlying their functionality will be elucidated by a multidisciplinary approach combining microbiology, protein biochemistry, and X-ray crystallography techniques. Not only will the results facilitate a deeper understanding of the evolutionary diversification of pAgos, it will also enable the repurposing of progra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of elevated temperature aluminium alloys' (1994-1998).

assistant: **Innovation**

BE95-1151 Development of Elevated Temperature Aluminium Alloys It is proposed to achieve the industrial scale development of a low cost process of fabrication of a light material, based on the aluminium system (density of 3000 kg/m3), suitable for applications at 250 to 300øC. In case of success the developed products correspond to a potential market of at least 100 tons per year for applications, like the hot air conditioning tubes and the de-icing systems of the nacelles and of the leading edges of all European subsonic civil aircraft where the substitution of pure titanium by the new aluminium alloys could bring a weight saving of 20 to 40%, that is between 100 and 200 kg per aircraft, depending on its size. The main technical problem arising in the design of such a material comes from the necessity to marry two requirements which seem to be inconsistent: the alloy must be stable at 300øC, which means that it must keep high mechanical properties up to 300øC, but at the same time the alloy must be processable in conventional equipments, such as extrusions presses, with limited pressures. which means that the alloy must soften sufficiently at the temperature of working, that is 460 to 500øC. without any modification of its microstructure. So the developed process, defined by the following steps: - alloy composition, - atomization of powders, - cold and hot consolidation, - hot working, - final in house manufacturing technologies, will have to produce a material with high mechanical properties and good creep and fatigue resistance up to 300øC that can be processed with conventional equipments without damaging of its microstructure that might be detrimental to its performance, so as to fabricate large parts at a cost acceptable for the foreseen applications, that is infe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Human-Compatible Artificial Intelligence with Guarantees'.

assistant: **Innovation**

In this proposal, we address the matter of transparency and explainability of AI using approaches inspired by control theory. Notably, we consider a comprehensive and flexible certification of properties of AI pipelines, certain closed-loops and more complicated interconnections. At one extreme, one could consider risk averse a priori guarantees via hard constraints on certain bias measures in the training process. At the other extreme, one could consider nuanced communication of the exact tradeoffs involved in AI pipeline choices and their effect on industrial and bias outcomes, post hoc. Both extremes offer little in terms of optimizing the pipeline and inflexibility in explaining the pipeline’s fairness-related qualities. Seeking the middle-ground, we suggest a priori certification of fairness-related qualities in AI pipelines via modular compositions of pre-processing, training, inference, and post-processing steps with certain properties. Furthermore, we present an extensive programme in explainability of fairness-related qualities. We seek to inform both the developer and the user thoroughly in regards to the possible algorithmic choices and their expected effects. Overall, this will effectively support the development of AI pipelines with guaranteed levels of performance, explained clearly. Three use cases (in Human Resources automation, Financial Technology, and Advertising) will be used to assess the effectiveness of our approaches.


**Keywords:** Fairness, transparency, explainability, control theory