RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Health virtual twins for the personalised management of stroke related to atrial fibrillation'.

assistant: **Objectives**

Atrial fibrillation (AF) is the most common heart arrhythmia worldwide, leading to life-limiting complications, high financial burden and significant resource utilisation. In Europe, stroke as a debilitating complication of AF, is amongst the commonest causes of death and the leading cause of disability. AF patients have a 5-fold increased risk for ischaemic stroke. Functional recovery from AF-related stroke (AFRS) is often unsatisfactory, leading to severe disability, reduced quality of life and high mortality.TARGET’s ambition is to develop novel personalised, integrated, multi-scale computational models (virtual twins) and decision-support tools for the AF-related stroke pathway, starting from the healthy state, pathophysiology and disease onset, progression, treatment and recovery. TARGET aims to help prevent AF and AFRS, optimise acute management and rehabilitation, reduce long-term disability, provide a better quality of life for patients and caregivers, and lower healthcare costs.We will ensure patients are at the heart of the project, and the association with experienced commercial partners will ensure the swift adoption of TARGET’s novel technologies. New observational data will be collected via 4 carefully designed prospective clinical studies, which will be used to test and validate the personalised tools and the virtual twin models using a clinical trial simulation (virtual/in-silico), to demonstrate evidence of clinically meaningful results.TARGET will also help consolidate existing mechanistic virtual twin models of the heart, the brain and the neuromusculoskeletal system, enriching these twins to deliver more complex tasks, and supporting research to move towards a more integrated human virtual twin. TARGET represents a milestone project to improve the ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Use of sea water in the sustainable development of cities of tomorrow' (1998-2002).

assistant: **Innovation**

The proposed method consists on application of sea water as coolant of urban A/C units. This will be achieved by a district piping network, distributing sea-water to urban cooling facilities operating with electrically or heat driven chillers in Residential, Commercial or Public use (i.e. airports, stations, etc). The energetic and environmental advantages of this system are due to the operation at lower temperatures, resulting in higher COP, compared to the conventional units.The environmental impact refers to a sharp drop of pollution and no overheating of the cities ambient air due to the no rejection of heat. By using this system, the urban aesthetics are improved, since the chillers can be installed indoors. Finally, the sustainable development will be secured, since cooling will become cheaper.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Compact reactor and carbon supported catalyst system for multiphase air oxidation'.

assistant: **Concept**

1. To develop a microchannel compact reactor system suitable for use in three phase catalytic air oxidation reactions. The geometry will be optimized to provide precise control of the oxygen concentration along the reaction pathway whilst providing enhanced gas-liquid-solid mixing and improved heat transfer.2. To develop the spherical mesoporous carbon catalyst support system required by the microchannel geometry for the two classes of oxidation reactions with the precisely tailored micro-rneso pore structure required for optimum catalyst performance.3.To develop the bimetallic (eg. Pt-Bi) catalyst systems that in conjunction with the optimized support and reactor will give the required performance in fine chemical and pharmaceutical manufacture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Formate for Renewable Energy Storage' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

FRESH aims to contribute to reducing the European Union’s dependence on fossil fuels for power generation, providing a cushion for the intermittent character of renewable electricity generation leading to stable, more predictable prices for renewable electricity, which is crucial for the future development of large-scale renewable power generation, and therefore, the energy transition. The project will achieve this through the development, construction and validation at TRL 4, of an integrated, cost competitive process for conversion of CO2 to potassium formate using an electrocatalytic process powered by renewable electricity. The highly stable potassium formate generated by the reactor will be stored safely for long periods (from short term or seasonal) in tanks. The subsequent conversion of the stored potassium formate to electricity on demand will use a direct fuel cell system. The project includes development of the individual components (CO2 to formate and formate to electricity), CO2 sourcing and purification and ultimately the construction and validation of an integrated protoype at TRL 4. This will be achieved by the implementation of a series of interconnected work packages. FRESH is structured around five technical work packages (WPs 2-6) and two ‘enabling/value adding’ work packages (WPs 1 and 7), supporting dissemination, exploitation and management activities. FRESH addresses the work program topic by (1) developing a new renewable energy storage technology (2) highly workable concept & approach, (3) implementation work plan & strategy, (4) a validated prototype at TRL 4, (5) participants with excellent track records for project execution and exploitation  and (6) comprehensive LCA and TEA and energy market evaluation of this new technology. The consortium
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Complex distillation columns' (1994-1998).

assistant: **Concept**

Objectives Distillation consumes large quantities of energy in the process industries. Process integration has proven to be very successful in reducing the energy costs for conventional distillation arrangements. However, the scope for integrating conventional distillation columns is often limited. These limitations can be overcome by using non-conventional column designs. If the full potential for thermal coupling was applied effectively throughout the European petroleum, petrochemical, and chemical industries, it would create enormous energy savings. Before the full potential of thermal coupling can be established across the European industry, further work is required: (i) to refine the design procedures to allow a wider range of designs to be analysed, (ii) to investigate theoretically and practically the hydraulic design of thermally coupled columns, (iii) to examine a range of generic processes (e.g. petroleum refining, ethylene production, etc.) to find suitable applications of the technology. Technical Approach One of the most significant non-conventional arrangements involves thermal coupling". Thermally coupled distillation column arrangements have been known for over 50 years. It has been established that when thermal coupling can be applied, energy savings of 30% are typical when compared with a conventional arrangement. In addition, the thermally coupled design, known as the dividing wall column, can save up to 30% of the capital cost compared with a conventional arrangement. Although designers have been aware for many years of the improved energy efficiency possible with thermal coupling, such designs have until recently not been used. The sole exception is the recent use of the design by BASF. The reason for reluctance to use these designs is rooted in thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CLUstering phenomeNA in nuclear physics: strengthening of the Zagreb-Catania-Birmingham partnership' (CLUNA).

assistant: **Concept**

Experimental nuclear physics is one of the top research activities at the Ruđer Bošković Institute (RBI), the largest Croatian research center in science and applications. The RBI nuclear physics group has strong link with the research group at the University of Zagreb (UoZ). RBI scientists perform experiments at the RBI Tandem accelerator facility and at the top EU experimental facilities in collaboration with the prominent EU research groups in the field, including partners from the Laboratori Nazionali del Sud INFN (INFN-LNS), Catania, Italy and the Nuclear Physics Group from the University of Birmingham (UoB), UK. With this project we propose to strengthen scientific relationships, the exchange of know-how and sharing of experience between RBI, UoZ, INFN-LNS and UoB partners in the research field of our mutual interest, focusing on the studies of nuclear molecules and other areas at the forefront of research for new phenomena in nuclear physics.  This will be achieved by: (i) reinforcement of RBI experimental capabilities through the upgrade of the local experimental facility, (ii) exchange of personnel between partner institutions, hiring and training of young staff at accelerator facilities, (iii) organization of workshops. Upgraded research infrastructure for low energy measurements at RBI and complementary facility at INFN-LNS for intermediate energy measurements through this partnership would increase research opportunities for even broader European experimental nuclear physics community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Drastically reduced use of rare earths in applications of magnetocalorics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We will examine the life cycle of rare earth metals used in magnetic phase change technologies.  Our primary focus is on room temperature magnetic cooling, a near-market solid state alternative to gas compression in which a phase change “magnetocaloric” material is magnetised by a permanent magnet.   We will address the fabrication, manufacture and use of the magnetocaloric material, aiming:  (1) to reduce consumption and eliminate wastage of rare earths during the scalable manufacture of magnetocaloric parts; and (2) to drastically reduce the volume of rare earth permament magnet through a step-change improvement in the performance of low-rare earth or rare earth-free magnetocaloric materials.Such developments will reduce both raw material use and future technology cost, providing the necessary bridge between state-of-the art prototyping activity and industrially scalable production of magnetic cooling engines.  The project consortium includes materials physicists, researchers active in the industrial scale-up of parts manufacture, a magnet and magnetocaloric material supplier and an SME.  This combination will provide feedback between fundamental magnetocaloric material properties, material performance under test, and potential impact on product design.  A large-scale end-user partner will provide analyses of the life cycle, environmental and cost benefits of our research to the domestic refrigeration sector. The knowledge gained from our activities will be used in parallel for the development of magnetocaloric materials for a longer-term application: thermomagnetic power generation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A life-changing PREssure Sensor System for UROdynamics to solve global urinary storage and voiding problems'.

assistant: **Objectives**

900 million patients globally suffer from urinary dysfunction. Setting the right diagnosis and deciding upon the right treatment (medication, assistive devices, rehabilitation and/or surgery) can sometimes be very challenging. Today's technology provides a limited 15 min snapshot based on the artificial filling of the bladder. There is a clear need for a technology that can provide high resolution, accurate and realistic bladder pressure data over time based on natural filling. PRESSURO is a revolutionary micro and nanotechnology pressure sensor system based on more than 10 years of research at SINTEF. The sensor will be inserted directly into the bladder and enable continuous measurement based on natural physiology for up to 30 days.  This solution will provide a completely new understanding of bladder function and enable better diagnosis and treatment for millions of patients.


**Keywords:** urinary dysfunction , bladder pressure,bladder function,bladder function monitoring,bladder dysfunction diagnosis,bladder pressure monitoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Finance and Labor' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

How does financial market development affect employment, wages and unemployment risk? And how do labor market institutions and workers’ behavior in turn affect corporate policies?These issues are much under-researched, in spite of their prominence in public debate, often ideologically polarized between those who consider finance as socially harmful and those who view it as an efficient allocation machine. Most economic research indicates that financial development raises output growth, but is silent about its effects on the labor market: does it also raise employment and wages? If so, is it at the expense of greater employment risk and inequality? And how does the potential for systemic financial instability affect the answers to these questions?The study of these issues naturally opens also another – equally under-researched – line of inquiry: that concerning the effects of labor relations on financial arrangements. Do corporate investment policies and leverage decisions take into account their own effects on firms’ bargaining position in wage negotiations? And if so, how are these corporate decisions affected by job protection regulation, union density or workers’ protection in bankruptcy? To what extent do companies insure workers against employment risk, and do family and non-family firms differ in this respect? Finally, can labor market competition damage the performance of employees with decision-making responsibilities? For instance, can it induce managers or traders to take excessively risky decisions, by providing them with an escape route once they make mistakes, especially when outcomes are observed long after decisions?This research project purports to break new ground on both sets of issues, using a combination of analytical modelling and empirical analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Substrate docking and affinity studies of Nicastrin: the binding mechanism' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Beta-Secretase (beta-SEC) is responsible for the intramembrane cleavage of amyloid precursor protein, an event intimately linked to Alzheimer's disease (AD). Beta-SEC is an aspartic protease composed by presenilin, nicastrin (NCT), APH-1, and PEN-2.Beta-SEC appears to have a very broad specificity; however, no quantitative data is available to support this assumption. NCT subunit is a type 1 membrane protein whose ectodomain (NCT ECD) actively participates in the substrate binding. NCT-substrate interaction is an essential step in the beta-SEC mechanism.The characterization of this interaction is important to better understand the secretase specificity, but also because it represents an attractive point for the design of inhibitors.The project objectives are: determine structure-functional relationships (SFRs) to reveal the key functionalities in the molecular structure of the substrates that are responsible for recognition by NCT and therefore for beta-SEC activity or inhibition; evaluate the contribution of NCT on the complex specificity; generate and evaluate a entirely new class of beta-SEC inhibitors.The NCT ECD is reminiscent of aminopeptidase structures and the NCT-E333 function suggests a common binding mechanism. Taking advantage of this similarity, we will build a model for the NCT ECD to define and explore a putative binding pocket.BIAcore technology and isotermal titration microcalorimetry will be used to characterize the interaction between NCT ECD (wt or mutant) and the substrate ectodomains.To gain further insight into which functional groups are significant for substrate recognition we will use a set of compounds to investigate the effects on constants affinities, with special interest in inhibitory activities.In conclusion, we will generate quantitative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cholinergic and NMDAR-dependent recruitment of Layer 1 Interneuron shapes cortical motor Processing through network States Modulation' (InProSMod), addressing dissemination and exploitation.

assistant: **Impact**

In the sensory cortex of awake mice, spontaneous activity has been shown to exhibit various regimes, characterized by various levels of spiking activity. Such diverse activity regimes, termed network states, have a profound impact on the computational properties during sensory processing. In the mouse barrel cortex, a major top-down pathway modulating sensory input is represented by the integration of inputs from the motor cortex and associative thalamus onto layer 1 (L1). Here I will characterize the synaptic and circuit properties underlying top-down control of sensory network states during whisking in L1. Using a combination of synaptic biophysics, in vivo electrophysiology, 2-photon imaging and theoretical modeling, I will define the important role of L1 interneurons in decoding top-down processing of sensory information. This research will generate valuable information to advance our knowledge of cortical circuit dynamics during normal cortical operations, with crucial implications for several brain disorders.


**Keywords:** neocortical circuitry,  top-down control,  inhibitory interneurons,  NMDA receptor,  modeling of recurrent dynamics,  active sensation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metadata for Advanced Scalable Video Coding Tools', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The explosion of multimedia applications leads to a great expansion of video transmission over heterogeneous channels. These developments increase the need for highly flexible and scalable video compression systems. For all currently available interactive multimedia applications however, which are demanding in terms of video quality and coding efficiency, the cost as well as the limited scalability remain unacceptable. Therefore, MASCOT seeks to design an intrinsically scalable video-coding scheme providing fully progressive bit streams by exploiting novel morphological and adaptive wavelet decomposition methods. Furthermore, the project aims to improve the quality and efficiency of video coding systems by exploiting metadata information. The explosion of multimedia applications leads to a great expansion of video transmission over heterogeneous channels. These developments increase the need for highly flexible and scalable video compression systems. For all currently available interactive multimedia applications however, which are demanding in terms of video quality and coding efficiency, the cost as well as the limited scalability remain unacceptable. Therefore, MASCOT seeks to design an intrinsically scalable video-coding scheme providing fully progressive bit streams by exploiting novel morphological and adaptive wavelet decomposition methods. Furthermore, the project aims to improve the quality and efficiency of video coding systems by exploiting metadata information.OBJECTIVES1. To develop scalable compression schemes, which fulfil the requirements of multimedia applications, by covering a wide range of bit-rates, by yielding high compression ratios, and by providing a high level of bit stream embeddedness to enable the adaptation of the compressed video data to a