RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Catalysts for Synthesis of Stereodefined and Modifiable Tetrasubstituted Alkenes' under Horizon Europe.

assistant: **Concept**

Tetrasubstituted olefins are key to drug discovery, and the ability to such entities is a compelling goal. Pioneering studies have led to a number of noteworthy advances by significant shortcomings remain. For example, it is especially challenging to access tetrasubstituted alkenes that contain four sizeable substituents or a F atom and/or a CF3 unit. Most protocols can only afford one of the possible isomers. Tetrasubstituted alkenes that contain multiple modifiable substituents are particularly attractive, because they can serve as diversification points that lead to a large assortment of desirable compounds. Olefin metathesis offers a strategically distinct, efficient, and stereodivergent route to such entities. Yet, there are only a few reported olefin metathesis reactions that generate a cyclic tetrasubstituted olefin that does not contain two methyl substituents at each carbon (i.e., no stereochemistry). A much smaller number (four cases) are RCM reactions that afford cyclic tetrasubstituted olefins with one modifiable C–Cl bond. All involve a Ru catalyst. However, olefin metathesis reactions that can generate poly-halogenated olefins cannot be effected with a Ru catalyst (rapid decomposition). Only a Mo or a W catalyst must be used, but such complexes do not exist.We will design a new class of pivoting Mo and W catalysts that can be used to promote efficient RCM and cross-metathesis (CM) reactions that generate a wide range of readily modifiable tetrasubstituted olefins. We will accomplish this by designing catalysts wherein the rotation of the imido and aryloxide ligands is synchronized, so that a proper binding pocket is made available. The expected products, which can serve as versatile diversification points, will contain 2-3 easily modifiable units. We will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DimerCat: Isolated dimers for catalyzing CO2 electroreduction to higher carbon products' (DimerCat), addressing dissemination and exploitation.

assistant: **Impact**

For the first time in human’s history, the level of CO2 in the atmosphere has reached the highest level of 415.26 ppm on May 11, 2019. This results in severe climatic change throughout the world.  Electrochemical CO2 reduction can convert this harmful CO2 to value-added carbon-based chemicals and is a carbon-neutral method of storing renewable electricity in the form of chemicals.This proposal aims to investigate carbon catalysts doped with metal-dimers as catalysts for CO2 reduction to higher-carbon (C2) products. Carbon-based catalysts are selected because of their high selectivity towards CO formation and the doped metal dimers are expected to favor the CO-CO coupling leading to the formation of C2 products. This would emulate the functionality of the nitrogenase enzyme, where V-V dimers are able to catalyze the formation of ethylene and other C2 products. The world-leading expertise of Prof. Magda Titirici (host) and Dr. Ifan Stephens; and the vibrant scientific community and state-of-the-art equipment at Imperial College, provide the perfect environment to successfully host my project despite its challenging nature. The deep expertise I have acquired during my Ph.D., in nanosynthesis and in-situ X-ray absorption spectroscopy of electrocatalysts would strongly complement my hosts’ expertise in carbon synthesis and operando testing. The bottleneck in the catalytic cycle will be identified and addressed. This new fundamental understanding will not only empower the scientific community but also enable the development of efficient electrocatalyst for higher-carbon product formation during CO2 reduction. Secondment will be carried out at Johnson Matthey that would allow us to scale-up the technology, developed at Imperial. Thus, the proposed project will try to solve the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MHP conformance testing improvement by development of new conformance tests in Europe' (MHP-CONFIDENCE) under Sixth Framework.

assistant: **Objectives**

MHP-CONFIDENCE will strengthen the DVB Multimedia Home Platform Standard (MHP) by strengthening its conformance- testing regime. The goal of the project is to develop new conformance tests as an enabling technology for the successful deployment of MHP components in the market. This will foster the integration of networked audiovisual systems and home platforms as well as the development of innovative services on the basis of interoperable applications.The project centres on the official formal conformance testing. It does not address the more informal inter-operability testing and is absolutely not intended to replace that. The project builds on the recent success of the European MHP Standard (published by EC in OJ 2002/C 331/04 of 31st Dec. 2002), but recognises some visible weaknesses of the very first MHP Test Suite launched by DVB which are critical for the competitiveness of both, the European standard as a whole, and the individual products of European manufacturers.The project addresses the development of conformance tests for the current version, but also for new versions of the MHP standard and thus maintains and reinforces European strength in an area where Europe has established a substantial industrial and technological leadership. With such an approach the project also responds to the emerging needs resulting from the current adoption or application of DVB-MHP (and its existing conformance tests) by other standardisation bodies like SCTE-OCAP in the USA or ARIB in Japan, whilst opening new opportunities for European technology.Strict and unified conformance testing - even across standards dialects" will ensure a smooth co-evolution of platforms and applications and will allow maximum exploitation of the technology by manufacturers, network operators, broadc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Identifying genes involved in environmental sensing and plant growth'.

assistant: **Objectives**

Glutathione (GSH) is an important and abundant reducing agent in plants. GSH is involved in tolerance and adaptation toenvironmental stresses, including drought, pollution and temperature extremes.The rate-limiting step in GSH production is catalysed by ga mma-glutamylcysteine synthetase (GCS). In Arabidopsis, twoGSH-deficient mutants define a single locus, ROOT MERISTEMLESSI (RML1)/CADMIUM SENSITIVE2 (CAD2),encoding GCS. The rmll mutant contains 2% of wild-type GSH levels and although embryonic development is normal,on germination, rmll root cells fail to divide and consequently do not maintain the root meristem. In contrast, shootdevelopment proceeds relatively normally. The rmll phenotype is rescued by exogenous GSH (but not other reductants)indicating the specific importance of GSH in root cell division. Moreover, wild-type plants phenocopy rmll whendepleted of GSH by a specific inhibitor of GCS, buthionine sulfoximine (BSO). In tobacco cell culture, BSO treatmentcauses a specific arrest in cell division a t a Gl checkpoint during the cell cycle. These results show a clear link betweencell cycle progression and GSH levels in cell cultures and in the root meristem. Here we propose to analyse its nature andmechanism by (a) establishing which known cell cycle g enes respond to GSH levels, (b) identifying novel genes that areaffected by GSH levels by using microarrays and (c) analysing the novel genes to find which are upstream regulators ofcell cycle targets. To achieve these aims we will use the specific GCS inh ibitor, buthionine sulfoximine, to deplete GSHlevels in the novel synchronizable MM1 and MM2d Arabidopsis cell lines in combination with the rmll and cad2mutants and examine gene expression. During this project the candidate will gain valuable scientific t rai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Bioactive Tissue Sealant for Enhanced Wound Repair'.

assistant: **Innovation**

Wound management is a routine part of medical practices worldwide, and delays in healing cause a significant clinical and economic burden. Current tissue sealant formulations that are used for wound care pose various limitations, including inability for filling in larger defects and release of toxic by-products (especially from synthetic polymers). Additionally, most of the commercial sealants provide no bioactive properties, or at best rely on bulk GF loading for inducing cell infiltration or tissue regeneration. The development of a tunable, bioactive hydrogel based tissue sealants thus provides an attractive opportunity as cell-instructive substrates for enhanced wound healing.BioTisSeal aims to develop the technology for fabricating “off-the shelf” bioactive tissue sealants that can not only help in wound closure (or reduce blood loss), but also stimulate better healing. BioTisSeal will combine the tunable elasticity and adhesive strength of gelatin methacryloyl (GelMA) pre-polymers with angiogenic growth factor (GF) specific aptamers that are capable of sequestering and concentrating  GFs that are already present in the tissue fluid at the wound site. By coupling this to the controlled release behavior of aptamers, a spatiotemporal control of GF bioavailability is achieved for enhanced wound repair.BioTisSeal will not only develop the technology to make this possible, but will also take vital steps to bring this technology to the market. By securing the IP, and analyzing the market connected to BioTisSeal technology, a fruitful basis for translation will be formed. The inclusion of both a leading wound care company and a clinician in the advisory board, will further ensure that BioTisSeal is optimally geared towards clinical translation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Magnetically driven Accretion and Ejection phenomena in aSTROphysics: a numerical study' (MAESTRO) under Seventh Framework.

assistant: **Objectives**

Many astrophysical phenomena involve highly nonlinear processes which take place on vastly different length- and time-scales: therefore, the modeling of complex astrophysical scenarios necessarily require a time-dependent multiscale approach. The objective of this project is to develop and employ High Performance Computing techniques to solve problems of astrophysical relevance. In particular the main aim is to work out fully three-dimensional models of accretion and ejection phenomena taking place in different astrophysical settings by recurring to high-resolution time-dependent magnetohydrodynamic simulations. The numerical experiments will be carried out by exploiting the PLUTO code for computational astrophysics. More specifically, two main problems have been selected: (1) the acceleration and collimation of astrophysical jets from magnetized accretion disks; (2) the interaction between a stellar magnetosphere and a surrounding accretion disk. These studies are essential to understand the fundamental processes which power astrophysical sources as different as Active Galactic Nuclei and Young Stellar Objects. For both three-dimensional problems the large range of spatial and temporal scales involved will require the use of specific computational tools to maintain an adequate spatial resolution in localized regions, reaching dynamically relevant timescales without excessively increasing the computational costs. With this purpose, we plan to improve existent or develop new grid-based tools to be implemented in the PLUTO framework, such as Adaptive Mesh Refinement or Cubed Sphere gridding. The implementation of these features in the PLUTO code represents a further effort to provide to the scientific community an extremely flexible and advanced public code to solve the m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'IMproving Sustainable Development Policies and PrActices to assess, diversify and foster Cultural TOURism in European regions and areas'.

assistant: **Objectives**

The main ambition of IMPACTOUR project is to create an innovative and easy-to-use methodology and tool to measure and assess the impact of Cultural Tourism (CT) on European economic and social development and to improve Europe’s policies and practices on CT, strengthening its role as a sustainable driving force in the growth and economic development of European regions. CT has been recognized as one of the drivers of growth, jobs and economic development, as well intercultural understanding and social development in Europe regions and urban areas.However, there is still a knowledge gap on methods to measure different types of CT impacts and to assess multilevel and cross-border strategies, policies and practices contribution to sustainable development.IMPACTOUR proposes to bring together CT-related stakeholders and researchers to achieve new approaches taking advantage of the large amounts of information that confront policy-makers. By identifying and comparing quantitative/qualitative pan-European information on CT forms and promotion, and by providing quantifiable evidence of CT strategies and their effect on European regions’ development and Europeanisation, IMPACTOUR will deliver an innovative methodology and tool (combining data analytics algorithms with artificial intelligence and machine learning strategies) providing CT stakeholders with strategic guidance so that policies and practices on CT can be improved. IMPACTOUR will encompass a sustainable ecosystem by engaging Cultural Tourism stakeholders and following a participatory approach. IMPACTOUR tools and methods will lead to reinforcing the commitment with Europe CT, increasing citizens sense of belonging, valorisation of minority cultures, strengthening of identities and Europeanisation. IMPACTOUR Methodolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Numerical simulations of slow instabilities in stellar systems - a low-noise numerical technique applied to long-term evolutions'.

assistant: **Innovation**

The long-term evolution of stellar systems (star clusters, galaxies) is a perturbation problem very difficult to study by standard techniques: analytic techniques are restricted in general to linear solutions, while numerical n-body simulations are plagued by the excessive discretization due to their limited number of particles. An original method combining analytical models for the initial state with an n-body simulation for the perturbation has been developped (PhD of the applicant) that reduces the effects of dicretization. We plan to increase the power of the method by increasing the role of the analytical modelization; this would be achieved by including periodically during a simulation any growing non-linear perturbation in the analytical model. The aim is to describe problems that are both most relevant to evolution of stellar clusters and out-of-reach of present techniques: the time-scales and the non-linear evolution of slow, lasting perturbations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'THE ULTIMATE ROOT CANAL OBTURATION SYSTEM' under Horizon 2020.

assistant: **Concept**

With a market forecasted to reach ~$21 billion by 2023, the prevalence of root-canal treatments is expected to increase in the following years, due to the global rise in elderly population, incidence of dental caries, etc. However, statistically, these treatments fail long-term in up to 50% of the cases due to the lack of 100% efficient obturation techniques: currently commercialized root-canal filling solutions are complex, time consuming, expensive and may hinder the placement of a post (used to increase the tooth´s resistance) or retreatment (needed when the root canal treatment fails)- due to the presence of a plastic core which is left inside the root canal. At CMS Dental we have been developing dental products for endodontic and periodontic treatments for over 20 years. Our close relationship with dental product distributors (our customers) enabled us to identify their need for cost-effective root-canal filling solutions that would meet the demands of dentists for fast, easy to use systems that also enable and facilitate retreatments (i.e. eliminate the plastic). And so, to solve these problems we have developed Soft Core 2K, the first carrier-based root canal obturation system made 100% of gutta percha (GP- natural, biocompatible polymenr) which, thanks to its two-component design (with two kinds of GP) grants an efficient, dense three-dimensional filling (including lateral root canal fillings), as well as a successful post placement and retreatment. The market launch of Soft Core 2K will be a great boost for our company, enabling us to become leader providers of root-canal filling systems: not only will it imply a 160% increase of our current revenues by 2022 (€4.5 million) and a 55% increase in our staff, but it will also enable us to enter the Asian market, so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bridging the sex gap in traumatic brain injury biomechanics' (2021-2027).

assistant: **Innovation**

Traumatic brain injury (TBI) is a multi-anatomical-scale mechanical injury affecting 30 million women globally each year. brainsex will focus on the sex specific biomechanics of TBI in the elderly population motivated by the highest reported incidence of TBI in people over 75 years old. Furthermore, in the elderly population women account for more TBIs than men. However, women remain underrepresented in TBI research. Finite element brain models (FEBMs) have played a major role in improving our understanding of TBI. However, current FEBMs have been developed using male-only data and cannot accurately model female TBI due to the distinct sex specific neuroanatomies. I will embark on frontier research to test the hypothesis that TBI biomechanics are sex specific due to the multiscale sex specific neuroanatomy, causing damage to brain tissue, cerebral vasculature, and neurons under lower impact forces in women compared to men. To realize this ambitious goal, my team and I will develop ground-breaking sex specific FEBMs incorporating the multiscale sex specific neuroanatomy and constitutive damage properties of brain tissue and cerebral vasculature providing more accurate predictions of TBI from high energy head impacts. We will develop novel experimental technologies to characterise the constitutive damage properties of brain and cerebrovascular tissue (Aim 1), and neurons (Aim 2) under conditions required to model brain deformation during TBI. This data will be used to develop the first ever microstructure-informed constitutive damage model for brain tissue (Aim 2). This model combined with the FEBMs will revolutionise TBI biomechanics (Aim 3). brainsex will open new research horizons for biomechanics research focussing on the important role sex plays in tissue biomechanic