RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PLETHORA transcriptions factors, new players in the control of phyllotaxis in Arabidopsis thaliana' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The mathematical regularity of plant organ initiation, also known as phyllotaxis, has always intrigued mathematicians and botanists. Only recently was established that the plant hormone auxin has a major role in regulating organ positioning at the shoot apex of plants. Specific spatial accumulation of auxin induces organ formation and control organ spacing. The current model for phyllotaxis relies on polar auxin transport via auxin efflux facilitators of the PIN family, and postulated positive feedback loops between auxin and PIN proteins. However no regulatory mechanism and gene network have been proposed yet to explain how organ positioning is controlled in plants. The proposal aims to bridge this gap by using a unique genetic tool generated in the host laboratory, a mutant in the plant model Arabidopsis that switches from wild type spiral organ arrangement (organs arising by a divergent angle of 137.5º) to a decussate pattern (organs arising in opposite pairs). The mutant is impaired in three genes that belong to the PLETHORA (PLT) family genes previously described in roots as involved in a regulatory loop with auxin and PIN proteins to maintain an auxin gradient and root meristem function. This is the first time that a stable change in phyllotactic pattern has been observed in an Arabidopsis mutant, giving a real opportunity to understand regulatory mechanisms underlying behind this developmental process. The PLT genes impaired in this mutant are expressed throughout the shoot apical meristem, i.e. in the peripheral zone where are initiated organ primordia and in the central zone where are lying the stem cells, suggesting a role for PLT genes in establishment of phyllotactic patterns and in shoot apical meristem function. The aim of the project is to understand if P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of an integrated computer aided design and planning methodology for underground marble quarries'.

assistant: **Objectives**

Objectives and content The EU dimension stone industry, which mostly involves small and medium size enterprises, enjoys at present health and growth. Exhaustion, however, of near surface reserves coupled with environmental effects to the surroundings forces the industry to move gradually underground as an alternative to closure. To continue its successful operation in the difficult and unfamiliar underground terrain and to face this challenge and involvement in a risk business, an integrated scientific approach to the problems associated with underground marble exploitation is urgently needed in order to minimise expected rising production costs due to: lower recovery, limiting space of operation, pillar and roof stability, to mention only a few of the problems an underground quarry operation will encounter. The risk problem can be met by predicting block recovery in terms of size, quality and quantity, and the rising costs by optimising design of the rooms and pillars since it affects both, recovery through size and orientation of underground works, and productivity through space availability and safety of working conditions. As the currently extant design methodologies have been developed in a piecemeal fashion over a number of years, they neither reflect the state of the art of rock engineering nor are they adequate to determine exactly what is the minimum amount of mineral to be left in place. This latter deficiency stems in part from the difficulty in predicting the mechanical behaviour of the material, and in part from the critical importance of not underestimating the support requirements. This proposal, which is addressed both to already operating underground marble quarries and to quarry owners that soon will be facing the problem of going underground or closin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electron Beam Emergent Additive Manufacturing' under Horizon Europe.

assistant: **Concept**

The objective of project is establishment of a new excellent Centre for Electron Beam Precision Manufacturing (EBEAM Centre) with international research team led by an experienced researcher prof. M.H. Rmmeli - ERA chair, to help exploit the research potential of the use of electron-beams to fabricate and structure new materials at the atomistic level and to enhance performance in research, innovation and education in nanotechnology as well as energy and environmental technologies and visibility of VSB-TUO at international level. The project is also aimed on implementation of structural changes in research environment and science management at VSB-TUO initiated by ERA Chair, to develop a research environment that meets the highest international standard, and on support of young researchers who will strengthen their creative and innovative potential via their engagement in the project and make use of the international dimension of the project for gaining independence and career development.  The EBEAM project will have regional and national impacts in terms of research, education, and technology according to Research and Innovation Smart Specialization strategy.


**Keywords:** atomic and close-to-atomic scale manufacturing, advanced materials, atomic devices, novel materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'BIOSENSOR DEVELOPMENT FOR THE RAPID DETECTION OF ANTIBIOTICS IN MILK' (BIODAM) under Fourth Framework.

assistant: **Objectives**

The overall objective of this precompetitive project is to develop biosensor technology that can be applied to the detection of antibiotic residues in milk. It will involve the development of prototype biosensors for the multi-detection of antibiotics, including sulfonamides. This will be achieved in a highly innovative way by the joint exploitation of technologies in the unrelated fields of immunology, integrated optical microtechnology and computer software engineering.To overcome the problem of sensor life-time it will be designed to have a cheap and disposable probe that can be easily replaced after coming into contact with an antibiotic.The resultant technology should be applicable to laboratory instruments for detecting antibiotics in milk and also to systems to detect milk contaminated with antibiotics in-line at the farm and processing dairy. As a model, the prototype biosensor will be developed to detect some groups of the more frequently found antibiotics (aminoglycosides, 3-lactams, sulfonamides and tetracyclines) that contaminate milk. This will be achieved by first synthesising the appropriate conjugates and then producing generic monoclonal and recombinant antibodies (for aminoglycosides only). By employing generic antibodies, it will be possible to detect all the related antibiotics in each major group of antibiotics. The antibodies produced will be validated to determine their specificity and sensitivity. Using proven techniques, the antibodies will then be covalently attached by photo-linking to the waveguide of the optical signal transducing layer of the biosensor. The performance of the prototype biosensor will be evaluated in comparison with chemical methods for analysing antibiotics in milk to determine its sensitivity, specificity and durability. O
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regulation of neuronal connectivity and plasticity by activity-dependent mitochondrial trafficking to synapses' (FUELLINGSYNAPSES), addressing dissemination and exploitation.

assistant: **Impact**

Regulated trafficking of mitochondria is essential for providing ATP at the correct spatial location to power neural computation, and for providing calcium buffering at sites of calcium entry or release. In neurons, the concentration of mitochondria in specific regions such as growth cones and synapses is important for correct neuronal function and development. Moreover mutations in proteins regulating mitochondrial trafficking compromise neuronal development and the formation, function and plasticity of synapses, and defective mitochondrial trafficking is increasingly implicated in neurological diseases. Understanding the molecular mechanisms that allow neurons to tailor the distribution of mitochondria to changes in neuronal activity therefore has important implications for our understanding of neuronal function and communication. This proposal will study the mechanisms that control the trafficking of the energy providing mitochondria within neurons, and how this relates to neuronal connectivity and plasticity. Using imaging, electrophysiological, molecular and cell biological techniques, combined with viral transduction and mouse transgenic approaches we will determine the molecular mechanisms underlying the activity-dependent subcellular positioning of mitochondria in neurons. We will examine how the mitochondrial Ca2+-sensing GTPases Miro1 and Miro2 act to regulate mitochondrial movement, distribution and function and how this contributes to neuronal development, synaptogenesis and synaptic plasticity. A key goal will be to determine if different roles exist for constitutive versus activity-dependent control of mitochondrial transport by Miro1 and Miro2 in these processes. These studies will significantly advance our understanding of the molecular mechanisms that c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geometric Models for Calabi-Yau Algebras and Homological Mirror Symmetry' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In this project, I will establish new connections between cluster algebras, mirror symmetry and representation theory through the introduction of geometric models. Mirror symmetry is a natural phenomenon, first observed in superstring theory, consisting of two main approaches: the A-model, focused on the symplectic side of a Calabi-Yau manifold X, and the B-model, focused on the complex side of the manifold. Mirror symmetry is a duality between the two models. Based on this, Kontsevich formulated his famous homological mirror symmetry conjecture for categories. In this conjecture, the A-model is the Fukaya category of X, and the B-model is the derived category of coherent sheaves of X^. Cluster algebras were introduced in the early 2000s to provide a combinatorial framework for dual canonical bases. Many new ideas in representation theory have their origin in cluster algebras, bringing together category theory, particularly Calabi-Yau categories, combinatorics and the geometry of Riemann surfaces. In exciting recent developments cluster theory and homological mirror symmetry have been linked through scattering diagrams, opening up both theories. In this project, I will study the connections between cluster combinatorics and scattering diagrams through Calabi-Yau algebras, which appear in a natural way in cluster theory and mirror symmetry. I will develop geometric models for the representation theory of Calabi-Yau algebras encoding, in particular, their (co)homology. This will lead to a complete understanding of these algebras and their role in the mirror symmetry program. Dimer models are intrinsically linked to both cluster algebras and mirror symmetry. As part of my project, I will generalize dimer models to the general setting of special multiserial algebras. Both C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Protective role of antioxidant enzymes in legume nitrogen fixation' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content Nitrogen fixation is a process that needs to be promoted under natural conditions because it is is largely beneficial, both economically and environmentally, as compared with chemical fertilization. Legwne root nodules contain a variety of antioxidant metabolites and enzymes to cope with activated oxygen species formed in the respiration process. Two critical antioxidant enzymes are ascorbate peroxidase (APX) and gluthatione reductase (GR). Lipoxygenase (LOX) is a likely candidate to generate activated oxygen because it catalyses the oxidation of polyunsaturated fatty acids. By studying simultaneouslythe expression of antioxidant enzymes and nitrogenase during nodule ontogeny and senescence, important information can be gained on the protective role of antioxidants during nodule operation and on the mechanism underlying senescence. I will investigate in detail APX, GR, nitrogenase and LOX. My main objectives will be to study how expression of APX and GR is regulated during nodule forrnation and senescence, and to demonstrate that these antioxidants are involved in the protection of nitrogenase by using a combination of molecular, cellular, and physiological techniques. As a summary, the particular tasks to be performed within the above-mentioned objectives are the measurement of enzyme activities (spectrophotometly, fluorometry, gas flow-through systems), proteins (Western analysis, immunolocalization) and mRNAs (Northern analysis, in situ hybridization) for APX, GR, nitrogenase and LOX. Details are given on the research description. Training content (objective, benefit and expected impact) This type of approach is novel and should yield important results with application in agriculture. It will provide irnportant inforrnation and some cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Lapland Atmosphere-Biosphere Facility'.

assistant: **Concept**

The Lapland Atmosphere-Biosphere Facility, LAPBIAT, consists of seven installations, which are spatially distributed in Finnish Lapland over 500 km range. LAPBIAT offers an access to study the interactions between the thermosphere, mesosphere, stratosphere, troposphere, biosphere and various types of ecosystems from Taiga to Tundra in the vicinity or north of the Arctic Circle.The wide variety of disciplines and northern ecosystems represented in the LAPBIAT installations, combined with a highly developed science infrastructure and ready accessibility from all parts of the world, offers visitors interdisciplinary science possibilities that are unique in the world. The scientific tradition is exceptionally long as well. The earliest expeditions date back to t he first geophysical year 1882/83 and the oldest homogenized still continuing atmospheric data sets are nearly 100 years old. Some of the long-term ecological datasets are over 50 years old and long-term field experiments, such as simulated acid deposition experiment have been in operation already for 20 years.LAPBIAT offers access to on-line satellite data and long-term continuous recordings of many physical quantities reflecting the changes in the Earth's electromagnetic environment and the impact of external disturbances of solar origin on the Earth's system. LAPBIAT offers access to EISCAT incoherent scatter radar system and other ground-based instrument networks, which form a most powerful tool for studies of the ionosphere and atmosphere from stratosphere to thermosphere. By offering an access to this high-class combination of installations LAPBIAT enhances the scientific level of European research. At the same time it gives more research opportunities for European researchers, and enhances the co-operation be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Selecting a Uniform Electoral System for the European Parliament' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and contentResearch training proposal of Annemarie ter Veer Selecting a uniform electoral system for the European ParliamentabstractWith the purpose of selecting a uniform electoral system for the European Parliament, the project compares the election rules in member states of the European Community (EC) and the methods of apportioning seats. Initially, these rules and methods will be analysed by the features of their outcomes in game theoretical models of European parliamentary elections. Subsequently, the rules and methods with the most attractive features will be compared by means of their mathematical properties and by means of empirical material. The project will provide policy recommendations concerning the suitability of election rules as uniform rules for the election of the European Parliament and concerning appropriate methods of apportionment. Furthermore, the project studies the effect of the implementation of the most suitable election rule(s) and method(s) of apportionment on the present distribution of seats in the European parliament.Training content (objective, benefit and expected impact)Objective: to deepen the candidate's knowledge in her own field of research (social choice, game theory and political theory) and to develop her capacities concerning applied research. The candidate will greatly benefit from the multidisciplinary expertise at an outstanding and international institute such as THEMA (second best research group in economics in France).Content:Regular meetings with the supervisor, J-F. Laslier, whose research is closely related to the project;participation in two weekly seminars on public economics, social choice, game theory, ethics and philosophy and political science;group work at THEMA (in particular the INTAS proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Protein aggregation - an interdisciplinary school' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The discovery that protein aggregation plays a role in a number of different neurological disorders has thrust this phenomenon into the limelight as a very important current topic in the life sciences. The most important of the aggregation diseases are Alzheimer's disease, Parkinson's disease and the prion diseases, which include Bovine Spongiform Encephalopathy (BSE) and Creutzfeldt- Jakob disease. The prion diseases apparently propagate without transmission of genetic material, but instead by a mechanism that is closely linked to fundamental biophysical properties of aggregation: nucleation and seeding. This means that biochemical and biophysical studies can contribute in an unusually direct fashion to understanding the diseases and hopefully to the development of treatments.The key idea behind the proposed event is to expose the students to a highly interdisciplinary approach to protein aggregation. In order to truly understand this problem, the student or researcher must have knowledge from very different fields; from pathology through biochemistry and experimental biophysics to theoretical physics. As organizers our most important objectives will be to secure first-class lectures that covers these topics, and to insist on presentations that can be grasped simultaneously by students from the different fields.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00426-1.pdf