RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Elucidate Aurignacian Through Archaeozoological Analysis of Subsistence' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project focuses on the origins of modern humans in Europe and the replacement of Neandertals by these incoming humans. 45000 years ago only Neandertals lived in Europe, but by 30000 years ago only modern humans remained, associated with the Aurignacian Upper Paleolithic culture.For many years, much research has focused on the fate of Neandertals and their relationship to the Aurignacians. My objective is to illuminate the origins of the Aurignacian.The diversity seen in the earliest Upper Paleolithic industries raises the question of if the Aurignacian has a single origin or if it evolved in multiple places; and if the local variations are regional variants, adaptations to the local ecology, or indicative of specific activities?I propose to examine the variation in the Aurignacian using an independent line of evidence, diet, through the study of animal remains discovered in archaeological deposits. Sociological and ethnographic studies have shown the value of diet for defining group identity. The Aurignacian is best known from southwestern France and Germany.Although animal bones are preserved in many of these deposits, few detailed subsistence studies exist. I will investigate Aurignacian subsistence by undertaking a comparative approach.I will collect data on many archaeological and paleontological faunal assemblages throughout the areas of interest, using personal study of the bones and published sources. For my primary reference sample, I will conduct a taphonomic and zooarchaeological investigation at Brassempouy (Landes, France).Conducting this research in the international and multi-disciplinary context of the Department of Human Evolution at the Max Planck Institute from Evolutionary Anthropology in Leipzig, Germany will give me the opportunity to collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monitoring Earth Evolution Through Time' in the context of a Horizon 2020 call.

assistant: **Objectives**

Efforts to reconstruct the early Earth evolution lack critical information on the contents of mobile and volatile elements and their isotope signatures in the mantle and crust. Fortunately, this information is preserved in inclusions of melt in relicts of olivine from komatiites and picrites, and zircons from mafic and felsic rocks. In Aim I, we will use compositions and temperatures of primary mantle-derived melts reconstructed from the study of melt inclusions in olivine from komatiites and picrites to constrain the evolution of mantle composition. We will further study crust-formation, crust-mantle recycling, and crust-hydrosphere exchange based on composition of melt inclusions and host zircons. We will analyse a wide range of volatile elements and their isotopes in homogenized melt inclusions and the elemental and isotopic compositions of host olivines and zircons. The samples come from 24 localities of komatiites and picrites originating at different cratons between 3.7 and 0.06 Ga, and detrital and magmatic zircons with ages from 4.4 Ga to present. We will apply published and new models to constrain the temperatures and compositions of mantle and crustal sources. In Aim II, geodynamic modelling will relate our observations to the evolution of mantle convection, crustal production and recycling, and plate tectonics (PT). We will couple geodynamic modelling with surface and climate models and use derived geochemical proxies to test our hypotheses on the importance of surface processes in evolution of PT. We will thus address several fundamental issues: the rate of crustal growth and recycling through time; the cause and timing of the onset of large-scale subduction and PT, and factors controlling its evolution; concentration and origin of H2O and halogens in the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Angiogenesis-metabolism crosstalk in vascular homeostasis and disease' (ANGIOMET).

assistant: **Concept**

Blood vessels pervade all tissues in the body to supply nutrients and oxygen. Aberrant vessel growth and function are hallmarks of cancer and cardiovascular diseases and they contribute to disease pathogenesis. Antiangiogenic therapeutics have reached the clinic, but limited efficacy and resistance raise unresolved challenges. The current limitations of angiogenic medicine call for a more integrated understanding of the angiogenic process that focuses not only on the instigators of vessel branching but also on mechanisms that sustain vessel growth. Recent insights into fundamental aspects of cell growth move metabolism into spotlight and establish how proliferating cells reprogram their metabolism to provide energy and building blocks for cell replication. During angiogenesis, endothelial cells (ECs) also convert between growth states: although mostly quiescent in adult tissues, ECs divide and migrate rapidly upon angiogenic stimulation. To allow growth of new vessel branches, ECs therefore need to adjust their metabolism to increase energy production and biosynthetic activity. However, the molecular mechanisms that coordinate EC metabolism with angiogenic signalling are not known to date. In this proposal, we put forth the hypothesis that metabolic regulation is a key component of the endothelial angiogenic machinery that is required to sustain vessel growth. Thus, this proposal aims (I) to define transcriptional circuits that link EC growth with metabolism, (II) to explore the regulation of these transcriptional networks by lysine acetylation, a nutrient-regulated protein modification with key functions in metabolism, and (III) to assess the role of sirtuin deacetylases for sensing endothelial energetics during vascular growth. Understanding the principles of angiogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital Twin of Earth system for Cryosphere, Land surface and related interactions' (TerraDT), addressing dissemination and exploitation.

assistant: **Impact**

To guide climate change adaptation and mitigation, reliable information on the regional and local impacts of climate change is needed. The Destination Earth (DestinE) initiative responds to this need by developing Digital Twins (DTs) of the Earth. In particular, DestinE Climate DT provides climate information at regional and local scales over multiple decades. However, the reliability of the impact assessments of Climate DT depends on the underlying km-scale climate models, which fail to represent some key components of the Earth system.We aim to enhance the DestinE infrastructure by developing a Digital Twin of the Earth system for the cryosphere, land surface and related interactions (TerraDT). TerraDT subscribes to the DestinE vision of building interoperable and interactive DTs, while pushing the resolution to km-scale, globally. TerraDT improves the descriptions of Earth system components in the DestinE climate models for land ice, sea ice, aerosols and land surface. TerraDT is based on a modular infrastructure with a coupling interface that enables adding new components or AI/ML-based emulators. TerraDT also develops impact models linked to the cryosphere and land surface to provide user-relevant information with interactive capabilities. TerraDT developments enable their full integration to the DestinE framework. Overall, TerraDT will improve the reliability and relevance of the climate projections and impact assessments of DestinE, which is critical for guiding adaptation and mitigation actions.The TerraDT consortium consists of 18 organisations with expertise in Earth system modeling, supercomputing and impact assessments. TerraDT will also engage with relevant users and stakeholders. The consortium includes the key partners from the DestinE Climate DT contract
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology' (REACT) targeting Horizon 2020.

assistant: **Abstract**

Malaria is an infectious human disease caused by parasitic protozoans of the Plasmodium type. P. falciparum causes the most lethal form with about 400.000 deaths annually. Pathogenesis involves expression of clonally variant molecules encoded by multi gene families at the surface of the infected host cells (erythrocyte). The most important virulence factor is called PfEMP1, which undergoes antigenic variation and is encoded by 60 var gene members. Despite the major scientific efforts, the molecular mechanisms orchestrating antigenic variation are still elusive. The reason is the lack of tools to perform genome editing in the natural epigenetic context, which is crucial in this important immune escape process.We aim to investigate antigenic variation of P. falciparum, by means of the recently developed CRISPR-Cas9 tool. This genome editing technology allows the in situ genetic manipulation of var gene regulatory elements in a native chromatin context. Virtually, any locus can be targeted by a RNA guide to insert, exchange or delete specific DNA regions including generation of point mutations without introducing a selective marker. Alternatively, we will use a dead Cas9 version (dCas9), which consist on the targeting of the desired locus by an inactive Cas9. This dCas9 can be fused to protein tags or effectors. We will use these techniques to i) delete cis-regulatory elements of var genes, ii) to identify factors associated to cis-regulatory elements by Cas9 targeted immunoprecipitations and iii) to engineer a tool to perform activation/silencing of specific var genes by fusing the dCas9 with epigenetic effector molecules (silencing and activators).This project will combine state-of-the-art techniques in genome editing to study malaria parasite virulence and provide relia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coordination of Agricultural Research in the Mediterranean' (ARIMNET).

assistant: **Innovation**

Agricultural research in the Mediterranean is characterised by three main features: it is scattered within the EU members and in Mediterranean Partner Countries as well as most of the problems and challenges that the Mediterranean agriculture is facing are shared by all the countries in the area and even further, its objectives are largely the same in the whole area, even if priorities can vary from one country to another; the conditions resulting from climate change as well as the objective of sustainable development and production need to rethink agricultural research in all the countries and to begin its alignment in the whole area to increase its impact. This situation allows and requires a coordination action at the level of the Mediterranean (among EU members and between them and the other Mediterranean countries) to fight again fragmentation in fostering the convergence of national programmes and in founding a new critical mass to address the key issues (such as the growing demand for safer, healthier and higher quality food; the sustainable production and use of renewable bio-resources; threats to the sustainability and security of agricultural and fisheries production resulting in particular from climate change), to increase excellence and relevance of research, to enhance and strengthen the cooperation within the region in sharing the objectives and the priorities. These are the aims of the proposal of an ERA-Net as a European Initiative for Coordination of Agricultural Research in the Mediterranean (ARIMNet) which bears clearly a double ambition: to enhance coordination of agricultural research programmes within the Mediterranean area and to improve the cooperation within the area. It is gathering twelve countries (6 EU members, 2 associated country and 4 oth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non-timber forest plant resource assessment in nw amazonia' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

* Carry out a market survey of NTFPP in NW Amazonia.* Carry out a comparative assessment of NTFPP resource availability in different forest types in three pilot areas in NW Amazonia.Expected Outcome* Improved knowledge of market situation for commercial NTFPP extraction in NW Amazonia.* Evaluations of NTFPP assessment techniques, with improved estimates of NTFPP usefulness of different forest types, also shown on maps.* Strengthening of research and fieldwork capacity of Latin American scientists regarding NW Amazonia forest ecosystems and NTFPP resource management.* Spanish book on NTFPP forest resources in NW Amazonia on the basis of the contributions from all researchers.The activities of the project are described in four work packages :1. Initial seminar for the project's participants: to get to know each other and to discuss relevant project issues at an initial stage, including organization, methods, publication policy, data handling, intellectual ownership, time schemes, benefits and goals.2. Market survey of NTFPP in NW Amazonia: comprising a reconnaissance of current level of commercialization of NTFP products in NW Amazonia, on basis of field visits to selected local, and regional/national markets.3. Assessment of potential NTFPP resource availability: comprising quantitative ethnobotanic and ecological research in plots of 0.1 ha and along transects in pilot areas in Ecuador (Yasuni area), Peru (basins of Ampiacu and Yaguasyacu rivers), and Colombia (middle Caquet river basin). Methods to estimate the potential usefulness of trees and lianas (down to 2.5 cm diameter) in forest types, recognised on recent aerial photographs and satellite imagery, will be compared and evaluated.4. Final book: includes editing of reports into chapters of the final book, which wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electronic spectra of cold, large interstellar ions' (ELECSPECIONS) under Seventh Framework.

assistant: **Objectives**

The purpose of this project is to measure for the first time gas-phase spectra of large carbon containing cations, at low temperatures, which are of astrophysical importance. Knowledge of electronic spectroscopy of such molecules is also of pertinence in a number of areas of chemistry and physics, enabling their identification in planetary atmospheres, flames and plasmas and as intermediates in chemical reaction dynamics. This project is interdisciplinary, bridging the areas of chemistry, physics, and astrophysics. It encompasses state of the art techniques of chemical physics and aims at obtaining information to solve the long standing enigma in observational astronomy, the identification of some of the molecules causing absorption of starlight in diffuse interstellar clouds. The project uses ion trapping technology, whereby mass-selected species are held in a radio-frequency field and the vibrations and rotations are relaxed by collisions with cold helium to typical interstellar temperatures of 10-30 K. The electronic spectra of a number of cations, selected on the basis of their special properties including those of bare carbon chains, rings and fullerenes, polycyclic aromatic hydrocarbon cations and their protonated forms will be measured using new detection schemes. The first approach is based on photo-induced charge transfer which is turned on upon laser excitation and the second uses the possibility of rare-gas complexation in the ground but not excited state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A molecular view of chromosome condensation' under Seventh Framework.

assistant: **Concept**

Eukaryotic cells inherit much of their genomic information in the form of chromosomes during cell division. Centimetre-long DNA molecules are packed into micrometer-sized chromosomes to enable this process. How DNA is organised within mitotic chromosomes is still largely unknown. A key structural protein component of mitotic chromosomes, implicated in their compaction, is the condensin complex. In this proposal, we aim to elucidate the molecular architecture of mitotic chromosomes, taking advantage of new genomic techniques and the relatively simple genome organisation of yeast model systems. We will place particular emphasis on elucidating the contribution of the condensin complex, and the cell cycle regulation of its activities, in promoting chromosome condensation. Our previous work has provided genome-wide maps of condensin binding to budding and fission yeast chromosomes. We will continue to decipher the molecular determinants for condensin binding. To investigate how condensin mediates DNA compaction, we propose to generate chromosome-wide DNA/DNA proximity maps. Our approach will be an extension of the chromosome conformation capture (3C) technique. High throughput sequencing of interaction points has provided a first glimpse of the interactions that govern chromosome condensation. The role that condensin plays in promoting these interactions will be investigated. The contribution of condensin s ATP-dependent activities, and cell cycle-dependent post-translational modifications, will be studied. This will be complemented by mathematical modelling of the condensation process. In addition to chromosome condensation, condensin is required for resolution of sister chromatids in anaphase. We will develop an assay to study the catenation status of sister chromatids and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Needs and requirements for independent living for older people' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The NARILOP project will develop effective methodologies to elicit the needs and preferences of older adults for technologies to help them live independently. Currently methodologies developed for use with young people are used without regard to their appropriateness for older people and there is evidence that they are indeed not appropriate for use with this group. Developing new technologies for older people is vital, given the ageing of society in Europe and beyond.  This timely research will fill an important gap in both research and practice in how to best engage with older adults in the design of technologies that will help them in independent living. The fellow on the NARILOP project will review the literature from human-computer interaction and other related disciplines for elicitation methodologies that have the potential to be used with older adult users and propose appropriate adaptations to make them fit for purpose.  The project will then use five adapted methods to undertake requirements elicitation work on a range of technologies related to cooking, food shopping and nutrition, an important but underrepresented area of technology innovation for older people.  Each method will be applied with five different groups of users. The data recorded during these elicitation sessions will be analysed for the attributes that lead to the most effective and acceptable elicitation methods for older adult users and for user requirements for the design of new technologies in the nutrition area. The project will create a manual of research methods and procedures for working with older people in the area of new technologies as well as a corpus of information about their needs for technological support in the kitchen.""