RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global Glacier Mass Continuity' (ICEMASS).

assistant: **Concept**

For the first time in history satellite data and respective archive holdings are now sufficient in terms of their spatial and temporal resolution, and their accuracy, to measure volume changes, velocities and changes in these velocities over time for glaciers and ice caps other than ice sheets on a global scale.The ICEMASS project will derive and analyse glacier thickness changes using satellite laser and radar altimetry, and satellite-derived and other digital elevation models, and convert these to a global glacier mass budget. Such data set will enable major steps forward in glacier and Earth science, in particular: constrain current sea-level contribution from glaciers; complete climate change patterns as reflected in glacier mass changes; quantify the contribution of glacier imbalance to river run-off; allow to separate glacier mass loss from other components of gravity changes as detected through satellite gravimetry; and allow improved modelling of the isostatic uplift component due to current changes in glacier load.These results will be connected to global-scale glacier dynamics, for which a global set of repeat optical and radar satellite images will be processed to measure displacements due to glacier flow and their annual to decadal-scale changes. The analysis of these data will enable several major steps forward in glacier and Earth science, in particular: progress the understanding of glacier response to climate and its changes; provide new insights in processes underlying spatio-temporal variability and instability of glacier flow on decadal scales; improve understanding of dynamic thickness change effects; allow estimating global calving fluxes; progress understanding of transport in glaciers and their role in landscape development; and help to better ass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'The impact of the tissue microenvironment on the microRNAs in chronic lymphocytic leukemia'.

assistant: **Concept**

Despite the advancement achieved in the treatment of Chronic Lymphocytic Leukemia (CLL), it remains an incurable disease. The current approach to handle CLL patients is “watch and wait” and the treatment starts when the disease is progressing. Therefore, one of the major challenges is to find genes responsible for the progression of the disease and discover the mechanisms that influence the expression of these genes. All relevant events of CLL occur in tissues where leukemic cells can be exposed to (auto) Ag stimulation and/or utilize microenvironment interaction to avoid apoptosis and acquire better growing conditions. We have recently identified several microRNAs deregulated over the progression of the disease. Here we propose  to investigate the influence that components of the microenvironment could have on the expression of microRNAs deregulated in CLL cells over the progression of the disease. We will purify CLL cells and the other cellular components from the three compartments in which CLL cells are located, bone marrow, lymphonodes and peripheral blood. We will assess the expression of selected microRNAs in B-cells after cell-cell mediated interaction. These experiments will clarify if stimuli generated from the cellular cross-talk are responsible for the dysregulation of the microRNAs related to the clinical progression, and in which compartment these events could occur. CLL cells will also be stimulated with plasma from patients with CLL at different stage of progression to identify a possible role of the soluble/secreted molecules on the regulation of the expression of those microRNAs. Together, these findings will lead the discovery of novel mechanisms underlaid the progression of the CLL and will provide new therapeutic targets helping the management of pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Curing EU aquaculture by co-creating health and welfare innovations' (Cure4Aqua).

assistant: **Innovation**

Farmed seafood is an important source of protein for food and feeds with a low-carbon footprint which has an important role to play in helping to build a sustainable food system. A strategic and long-term approach for the sustainable growth of a resilient EU aquaculture is, therefore, more relevant today than ever. However, the efficient and cost-effective control of pathogens remains among the main challenges for the sector, particularly relevant for Europe, where there is a great variety of species and production systems, which hinders the implementation of good husbandry practices tailored to each aquatic species. Through active engagement with key stakeholders, Cure4Aqua aims to jointly improve the resilience of EU aquaculture under environmental, biological, and socio-economic stress, by improving aquatic animal health and welfare and supporting the environmentally friendly, inclusive, safe, and healthy production of seafood. Cure4Aqua will do so by 1) developing cost-effective vaccines to prevent disease caused by 5 pathogens of economic significance to EU aquaculture; 2) Identifying markers with diagnostic capacity to be integrated to selective breeding programs to improve stress and disease management; 3) Developing innovative, bio-based and sustainable solutions as an alternative to antibiotics for controlling fish pathogens at various life stages and alleviate the pressure of global antimicrobial resistance; 4) Developing new tools and technology to improve health and welfare monitoring at the fish farm level and diagnostics of fish pathogens both at the laboratory and the fish farm levels; 5) Placing fish welfare at the foreground of aquaculture production, through the development of high welfare standards that consider different life-stages, production syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Variability of exchanges in the northern seas' (VEINS) under Fourth Framework.

assistant: **Objectives**

The project developed three 600MWe class supercritical coal-fired boiler designs, a traditional two-pass spiral wound design and two vertical ribbed tube furnace variants; based on a two-pass boiler configuration and a novel horizontal furnace arrangement. The project succeeded in targeting current absolute state-of-the-art steam conditions of 290barg/600°C/620°C at turbine inlet, which are limited by availability of suitable steam turbines rather than boiler materials. Innovative features have been introduced to the designs for improved plant costs, operability and flexibility. These include state-of-the-art materials, vertical internally ribbed tubing, improved separator design, improved mechanical details and integrated fuel reburn. Technical guidelines have been generated for the novel design features for application to future designs. A techno-economic assessment of capital cost and cost of electricity has provided a basis for selection of the most suitable design for demonstration.The overall objective of the VEINS proposal reads: To measure and to model the variability of fluxes between the Arctic Ocean and the Atlantic Ocean with a view on implementing a longer term system of critical measurements needed to understand the highlatitude oceans steering role in decadal climate variability. Exchanges between the North Atlantic and the Arctic Ocean result in the most dramatic water mass conversions in the World Ocean: Warm and saline Atlantic waters flowing through the Nordic Seas into the Arctic Ocean are separated by cooling and freezing into shallow fresh waters (and ice) and saline deep waters. The outflow from the Nolthem Seas to the south provides the initial driving of the global thermohaline circulation cell, the one to the north is of major impact to the lar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Complex microbial ecosystems multiscale modelling: mechanistic and data driven approaches integration.'.

assistant: **Objectives**

European dairy industry is an important agri-food sector; it represents more than 300,000 jobs and 10 billion € positive trade balance. Five out of the ten top global dairy companies are European and more than 80% of European companies are SMEs. More than 300 cheeses and dairy products are sold all over the world and are protected as geographical indications or traditional specialties. Mastering cheese-ripening processes to avoid sanitary risk and waste, and produce typical cheeses with organoleptic properties valued by the consumers is of economic and social significance. E-MUSE aims to develop innovative modelling methodologies to improve knowledge about complex biological systems and to control and/or predict their evolution by combining artificial intelligence and systems biology. This multidisciplinary strategy integrating genome-scale metabolic models, dynamic modelling methodologies, together with the design of efficient statistical and machine learning tools, will allow analysing of multi-omics data and linking the results to macro-scale properties related to cheese ripening and consumer preference. Bioinformatics has addressed this issue by data mining; however, a gap still exists between the molecular scale information and the macroscopic properties that E-MUSE will contribute to fill. Moreover, in the context of sustainable development, more and more consumers are diversifying their diet and consume plant-based food. Introduction of plant-based proteins in the cheese process brings issues such as bitterness or safety. Modelling strategies from the E-MUSE project will help to target and solve these issues. Finally, E-MUSE will train researchers with multidisciplinary skills in mathematics, bioinformatics and/or biology to design and use innovative multiscale m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FLAGELLIN AEROSOL THERAPY AS AN IMMUNOMODULATORY ADJUNCT TO THE ANTIBIOTIC TREATMENT OF DRUG-RESISTANT BACTERIAL PNEUMONIA' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Antibiotics constitute the standard of care but are faced with the emergence of antimicrobial resistance (AMR) and the curative failure. The FAIR consortium aims at assessing an adjunct to antibiotic therapy as an emerging concept of overcome AMR in pneumonia. The project leverages (i) a unique immunomodulatory flagellin that enhances airway epithelial innate immune defences and increases the therapeutic outcome relative to antibiotic alone, and (ii) airway-specific aerosol delivery by nebulization.FAIR's objectives are to:•develop nebulization modalities for optimal airway targeting and rapid action at the infection site•demonstrate that nebulized flagellin strengthens the response to antibiotics in relevant preclinical models of antibiotic-resistant pneumonia•identify host immune factors required for the gain of protection with systems biology•implement pharmacokinetics/pharmacodynamics model-based design and simulation for clinical validation•assess nebulized flagellin's safety in a Phase I clinical trial.•analyze the acceptability and economic relevance of the therapy•identify stratification markers that predict the course of pneumonia and treatment in antibiotic-treated cohorts. Expected outcomes include the enrichment of the pipeline of novel treatments against pneumonia, reinforcement of EU capacity to control AMR and infections, the Phase I safety report on nebulized flagellin, recommendations for future trials, and acceptability by the stakeholders and cost-effectiveness for public health.FAIR will develop new avenues of research on mechanisms of action of the adjunct flagellin, and will define (for future trials) the subpopulation of patients that might benefit most from this treatmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Coccidia parasites of commercially significant marine fishes in Ibero-Atlantic waters: Life cycle, ultrastructure and pathology' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The objective of the present project is to provide general information on the aetiology, life cycle and produced pathology of the different coccidian species parasites of the largest commercially exploited fish populations in the North East Atlantic Ocean at Ibero-Atlantic waters: Micrornesistius poutassou, Trisopteres luscus Trachuru trachurus, Sardina pilchardus,Scomber scombrus, Brama brama, Lepidorhombus whiffiagonis Platichthys flexus ans Scophtalmus maximus. Epidemiological studies for each of the parasitic host species analysed will be carried out and the relationship of the parasitic intensity with different condition index will be analysed.This will be of interest for the knowledge of the detrimental effect of the coccidiosis in fish condition, and therefore of the possibility of application in fisheries and mariculture. The results of this project will be compiled in order to the possibility of application for a better knowledge, evaluation and regulation of the fisheries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ExtraLytics: Big Data Analytics for Real Estate' under Horizon 2020.

assistant: **Concept**

Data is becoming the key to effective decision making in more and more aspects of modern society. Big data analytics provide insight into complex processes considering a breadth of factors. This promises to increase the efficiency of decision making in areas such as policy making, research, product development, or financial and retail markets. Currently, big data analytics is employed only by technologically savvy organisations with control over the relevant data. This further exacerbates the information asymmetry that has been plaguing many of these areas: real estate where buyers have long suffered from limited information, often controlled by the seller; or retail markets where sellers are now employing sophisticated competitive price intelligence solutions unaffordable to buyers. Who can tell you if it is better to buy a house with a garden or with a garage; or where renovations will yield more rent over time? ExtraLytics answers these questions through a combination of big data extraction and analytics. ExtraLytics introduces analytics and prediction models into DIADEM’s platform for accurate big data extraction from the web, which is able to extract required data at massive scale from the web. For the proof-of-concept, ExtraLytics initially focuses on residential real estate in the UK, a £4,135bn market (UBS), where buyers and renters are required to make fast decision with limited information—time on market is often below a week or even below a day as for desirable rentals in Oxford. “In an age when ‘big data’ is shaping our every move, how come an industry that takes so much profit can’t keep pace with technology and use it to actually deliver a service worth the money they take in commission?” (The Telegraph). ExtraLytics addresses this lack of data-driven anal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Active Flow Control system FOR improving HYDRaulic turbine performances at off-design Operation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The AFC4Hydro project addresses the development of a novel Active Flow Control (AFC) system for improving off-design operation of hydraulic turbines by mitigating deleterious flow phenomena during steady and transient operation including ramping of produced load. The main effect being increased reliability and flexibility, and reduced wear and tear. More specifically, this innovative and affordable AFC solution, allowing efficient utilization of existing hydraulic turbines, is planned to be validated at small scale in a model turbine and at large scale in two prototype turbines. A combination of technologies will be used to reduce the pressure and load fluctuations exerted on the machine induced by the draft tube flow using: (1) injection of pulsating momentum (IPM) with a specific frequency, amplitude and phase by means of actuators; (2) injection of continuous momentum (ICM) in the form of water jets with controlled speed and orientation directed against the swirling flow. A structural health monitoring (SHM) system will be developed to evaluate the effects of the injection systems in the structural response of the rotor, generator and bearings. These measurements will be used to optimise the machine performance. For that, a Controller will be programmed and tuned to reduce pressure fluctuations, structural loads and induced vibrations in real-time operation by continuously adjusting the injection systems. The final AFC system will also be tested against demanding transients like ramp up and ramp down. Special attention will be given to mitigate the powerful and dangerous flow instability provoked by the vortex rope breakdown. The success of the proposal will permit to extend the operating range of already existing turbines beyond the stablished safety limits, to incr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Highly-Reactive (Regenerative) Phosphorus Building Blocks -New Concepts in Synthesis' (Regenerative) under Seventh Framework.

assistant: **Objectives**

Fundamental research is key important to allow us to find new, economically and ecologically attractive ways to meet current challenges. The current depletion of available phosphorus resources is a concern. Unlike oil, which is lost once used, phosphorus can be recovered and used over and over again or at least transformed into other compounds of chemical use. The intention of the present research proposal is to contribute to the field of synthetic chemistry both, inorganic and organic,  by identifying and developing highly-reactive phosphorus building blocks that can be potentially regenerated. We would like to enter new avenues of phosphorus chemistry which will address fundamental questions and develop new applications. Using novel and powerful phosphorus reagents, new concepts for more efficient, selective and sustainable synthetic procedures will be developed. We also seek greener and more efficient processes and, whenever possible, to recover the phosphorus after the reaction. Phosphorus-based compounds will also be used in the recovery of industrial waste by-products such as phosphane oxides and depleted UF6, and will therefore have a positive impact on certain chemical industries and the environment.With our proposal we aim to address the following aspects:1) Synthesis of N-heterocyclic pnictanes (Pn = P, As, Sb, Bi with emphasis on P) and related cationic derivatives2) Exploration of N-heterocyclic phosphanes as reagents in organic synthesis.3) Preparation of catenated, branched and cyclic polyphosphanes via a novel method for P–P bond     formation – access tonovel polyphosphorus-based ligand systems.4) Alternative processes for the recycling of UF6 and related derivatives to access novel precursors for uranium chemistryand to recover fluorine based products o