RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'E-organisational metHodology and tools for Intra-European sustainable TOUrism' to be submitted under Fifth Framework.

assistant: **Abstract**

The marketing of tourism products to customers currently precedes through sales assistants of travel agencies. The tools are brochures, flyers, or publicity media. Tourism products are very numerous. Customers have a large variety of wishes and needs. The adequacy between the desires of the customer and the products proposed strongly depends on the extent of the sales assistant experience. In addition not all sales assistants are able to take the psychology of the customer into account. The aim of the Hi-Touch project is to develop software tools to be used by travel agency sales assistants for providing a tourist prospect with the best-adapted offer. As a matter of fact, large tourist operators have already set up homepages or market places. But they are mostly aimed at selling tickets. Complex, standard or customised packages are hardly to be found on the net. The new tools to be developed will not only be of direct use in travel agencies but will also be accessible on-line for staff. They will namely benefit to customised and regional tourism.Objectives:The general objective of the Hi-Touch project is to deliver a range of assistance tools, based on ITC new tools (XML, Java, Flash, ontological data bases and semantic descriptors, multi-lingual thesaurus) allowing a potential client to select efficiently and rapidly a set of products matching his concrete wishes and expectations. In the meantime, to provide incoming tourism organisations and travel agencies tools able to develop appropriate responses -even complex- based on regional resources, selling more efficiently their own products and assessing the general trends of the tourism demand.Main industrial and economic objectives are to propose prototypes of:1. An interactive game process allowing a prospect to expres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimal Public Procurement Services In The Healthcare Marketplace' (OPUS).

assistant: **Concept**

OPUS creates an efficient e-procurement mechanism that enables hospitals and pharmaceutical suppliers to electronically exchange contractual information, aided by the technologies of optimisation and business rules. OPUS mediation service provider will grasp the market opportunity, as this is triggered by the consumer's request, offer the participants the ability to dynamically constellate with other medical suppliers, and promote collective competition among the constellations. Appropriate settlement modelles will address the necessary contractual and/or value sharing arrangements spontaneously or dynamically. OPUS modules, entailing the various business perspectives, policies and market rules, will resolve any apparent conflict. The dynamic pricing modules will dismantle the generated product and disseminate the value among the implicated partners.Work description:The OPUS project introduces a new framework, in order to sufficiently support the Dynamic Value Constellation form of medical supply arrangements. OPUS addresses the healthcare supply chain in a unified approach and proposes an innovative procurement environment based on optimisation algorithms. Innovation can be seen in three different aspects, namely:1) Content;2) Planning;3) Price clearing.Current leading e-procurement solutions concentrate in the dynamic binding of buyer requests and seller offes. This does not fit at all with the requirements of the healthcare sector. The solution that OPUS proposes is a reverse auction optimised procedure.Milestones:1st Milestone (Month 9): Specification and design of the required infrastructure, an initial OPUS prototype & baseline report.2nd Milestone (month 16): Delivery of initial OPUS prototype and mid term report.3rd Milestone (month 24): Delivery of the final OP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of mitochondrial DNA double-strand break repair in human disease and normal ageing' to be submitted under Seventh Framework.

assistant: **Abstract**

Mitochondrial DNA (mtDNA) deletions accumulate in aged post-mitotic tissue and in individuals with neurodegenerative diseases, leading to local energy defects. Understanding the mechanism of mtDNA deletion formation is an essential step in trying to prevent their occurrence.My hypothesis is that mtDNA deletions occur during mtDNA repair via a double strand break (DSB) repair pathway. I will address the different components of this hypothesis by mechanistic studies of cell lines derived from patients, transgenic cell culture and in vitro biochemistry.This project also aims to identify and characterize novel mtDNA DSB repair factors. We will study candidate mtDSB genes by RNAi and confirm that the proteins are recruited to mtDNA after specific induction of mtDSBs. In a complementary approach we will search for protein interactions partners of the already identified mtDSB repair proteins by immunoprecipitations. Identified proteins will be analyzed in vitro, with the long-term goal to reveal the molecular details of human mtDSB repair.Further we will use patient cell lines and transgenic cell culture to identify new therapeutic pathways that can be used to counteract mtDNA deletion formation in neurodegenerative disease and normal ageing. If we can show as I propose that repair is the mechanism underlying mtDNA deletion formation, increasing levels of antioxidants could prevent the induction of DSBs and mtDNA deletions in neurodegenerative disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Actionable metabolite supplements to improve treatment response in pancreatic cancer', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The prognosis with metastatic pancreatic ductal adenocarcinoma PDAC is simply terrible, especially for those that do not respond to the chemotherapy, which is regarded as the standard therapy in most patients. More than half of the patients are non-responders and eventually pass away within months. It is therefore urgently needed to understand the differences among responder and non-responder patients, to develop alternative therapies that overcome the resistance and potentially further extend the survival for both groups. A recent hypothesis proposes the key role of microbiome and of the immune response in regard to tumor initiation, progression, as well as response to therapies. Diet, as a variable, introduces an additional layer of complexity, given its multifaceted impact on both the human microbiome and immune system, as our recent manuscript show. The metabolites produced by gut microbiota are influenced not only by diet, but also by a host of other factors. In ACT-PC, we propose the use of one or a combination of different microbiota-derived metabolites as a treatment to increase the efficacy of chemotherapy and at the same time to boost anti tumor immunity for PDAC patients. The overall goal of ACT-PC is to initiate the preclinical validation of specific microbiota-derived metabolites for improving treatment outcomes in PDAC patients. This project is designed to take our Technology Readiness Level from 2 to 4, enabling us to finalise the preclinical development within a subsequent  EIC Transition and initiate clinical validation and development soon after. In implementing the projects results we will leverage the PIs unique network that includes commercial partners and patient organisations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Nuclear risk-based inspection methodology'.

assistant: **Objectives**

The project NURBIM is proposed under Key Action 2 (Nuclear Fission) and addresses sub-section 2.1, Operational safety of existing installations. The general areas addressed by NURBIM in fulfilment of this Key Action are as follows: Development of risk-based methodologies in order to optimise inspection and maintenance of NPPs and systems with reference to both safety and economics.Promotion of best practice and a more integrated approach to inspect and assess NPP components within the European Union. Achievement of the objectives of NURBIM is strengthened considerably by the involvement of leading utilities and R&D organisations, and the association of the project with ENIQ (European Network for Inspection Qualification) on risk-based inspection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Living with Others, Living with Diabetes: Relational Care among Diabetes Patients in Delhi, India' (LIDIA).

assistant: **Concept**

The project examines relational care among diabetes patients from two social classes in Delhi: urban poor and the middle class. It will contribute to the existing ethnographic studies on diabetes and care by, first, providing an in-depth account of diabetes care in India, an underexplored case-country with a high incidence of the illness. Secondly, by providing a close ethnographic reading familial care, the study will break from earlier research on diabetes that largely focuses on self-care propagated by biomedical knowledge and institutions. Thirdly, the study will make theoretical contributions by developing a conceptual framework on relational care. It will do so by drawing on and bridging anthropological approaches that render care and and familial relatedness as forms of ongoing and habituated practices of the everyday, situated socioeconomically. The overall action will further researcher’s academic career, and create a platform of knowledge exchange between the researcher and the hosting Institution, Edinburgh Centre for Medical Anthropology (EdCMA).  Through the implementation of research project, the action will also enhance researcher’s academic skills and facilitate her academic career. The project will enable researcher to enhance academic skills through a close work with the principal supervisor Ian Harper and through an active participation at the EdCMA and relevant research environment. The researcher’s project will create added value to the department’s organisation, research environment and networking activities. By focusing on chronic non-communicable illness, it will supplement the already strong EdCMA’s focus on infectious disease and mental health in the Global South. The work will feed directly into I. Harper’s on-going research into the ethics of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Template for Regional Innovation System as a tool for evening out the regional R and D investment disparities' (TERIS), addressing dissemination and exploitation.

assistant: **Impact**

The objective of TeRIS is evening out the regional disparities in R&D investment allocation at national level by creating a template for functioning Regional Innovation System, RIS. TeRIS will increase participating regions??? R&D investments and thus improving regional competitiveness and helping the regions better fulfil the Lisbon goal.TeRIS template created contributes to empowerment of the RIS actors increasing their impact possibilities on R&D investment allocation. In that way the RIS w ill contribute to developing policy recommendations in order to help planning programmes better meeting regional needs. The structure of this CA is threefold concentrating on enhancing the functionality of a RIS, and thereby a RIS template development, opening up influence and interaction channels, through which forwarding recommendations to relevant authorities; and thirdly addressing the participation of SMEs. As an additional component of the activities TeRIS implementation plan includes an effective dissemination task.TeRIS coordination activities build on the doctrines of the theory of Learning Region.According to the model, the innovative capacity of a region is dependent on the production environment of the region and the organisations belonging to t he RIS, as well as the interaction occurring between them. The emergence of innovations requires an effective RIS with functional interaction. TeRIS is a CA of 9 partners. The coordinating organisation is Kemi Tornio Polytechnic (FI), and the other partners are University of Trento (I), Rovaniemi Polytechnic (FI), Region of Western Macedonia (El), Province of Trento (I), Regional Development Company of Western Macedonia (El), Rovaniemi Regional Development Agency (FI), Kemi-Tornio Regional Development Agency (FI) and Zeus Consu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comparing the effectiveness and safety of additional low-dose glucocorticoid in treatment strategies for elderly patients with rheumatoid arthritis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

GLORIA aims to prove that the addition of chronic low dose glucocorticoids (GC) to current antirheumatic therapy is highly cost-effective and safe in elderly patients with rheumatoid arthritis (RA). RA is a frequent (affecting > 2% of the elderly population), painful and disabling chronic disease with high societal costs. RA is associated with multiple comorbidities, polypharmacy and adverse events; these problems, together with challenges in compliance (adherence) are dramatically increased in the elderly population. About 50% of patients are chronically treated with low-dose glucocorticoids (GC) in combination with other antirheumatic drugs, but without good evidence on the balance of benefit and harm. Thus, existing guidelines and information on safety and efficacy of GC are inadequate.GLORIA will address these problems by conducting a large pragmatic trial: 800 elderly (>65y) RA patients receiving standard of care will be randomized to additionally receive 5 mg prednisolone daily or placebo for 2 years. Very liberal eligibility criteria will ensure representativeness to the target population, and most data will be collected from routine clinical practice, minimizing patient and physician load, and operating costs. A novel tool will monitor compliance; it can send personalized reminders to a patient’s smart device. The efficacy of this technology will be tested in a nested trial. Compliance and other characteristics will be entered into a model that will allow personalized risk and benefit assessment in the future.Qualitative research in patients and physicians of member states will explore expectations and challenges in guideline implementation. This information and the study results will enable an update to existing guidelines and patient information, in collaborat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel approaches to combat multidrug resistance (mdr) in pathogenic yeast (combating mdr in pathogens)' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

In view of the increasing threat of Candid infections, particularly to compromised-compromised patients due to non-availability of effective treatments, it is imperative to look for novel drugs with new targets. Such a search appears even more urgent as in Western world the common Candid strains acquire resistance to antiphonals (multidrug resistance, MDR) and thus, severely hamper successful therapy. In this context leading experts in the field have joined their efforts to combat MDR of C.albicans on the following complementary areas:1) systematic analysis of the functional domains of the transcription regulators and cell surface lipoproteins involved in MDR.2) Search for new targets of MDR transcription regulators by using micro-array DNA chip technology.3) Development of a screening system, in a suitable yeast background, for a block in an early regulatory step (including entry of the drug) in the acquired mechanism of MDR. This approach aims at (a) defining novel components of MDR and (b) screening for regulatory inhibitors rather than for new antiphonals, to which fungi are expected to develop resistance in due time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Human PPARa function in the vascular system'.

assistant: **Objectives**

Atherosclerosis is a chronic disease characterized by the accumulation of lipids in the arteries accompanied by a local inflammatory response. The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARa) appears to affect the development o f atherosclerotic lesions through its metabolic and anti-inflammatory effects. The role of PPARa in the control of lipid and lipoprotein metabolism has been extensively studied. Moreover, the role of murine PPARa has been studied in vivo using different mo use models of atherosclerosis. However, little is known on the activity of human PPARa in vivo in the vascular system. Therefore, the Goal of this project is to characterize the role of human PPARa protein in the control of vascular inflammation using an original humanized PPARa animal model (KIPPARa mice).To analyze the role of human PPARa protein in the atherogenic process in vivo, we will cross the KI-PPARa mice with an atherosclerotic mice model, such as the KIapoE2 mice. These mice exhibit plasma lipo protein characteristics that are equivalent to those of type III and IIB hyperlipidemic subjects, they develop spontaneous atherosclerotic lesions and they also respond to atherogenic high fat and cholesterol diets. KIPPARa mice have been recently generated in the host laboratory.This model has been validated by checking human PPARa mRNA and protein expression in different tissues. The metabolic consequences of human PPARa expression in KIPPARa mice are currently being analysed in the host laboratory. Therefore, taking into account both models, the generation of KIPPARa; KIapoE2 mouse model will be our original main tool to carry out this project. The results are anticipated to open new perspectives for human PPARa as a molecular target for the treatment of athero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mobile Freedom (MOBIFREE)' under Horizon Europe.

assistant: **Concept**

The Background to the development of the MOBIFREE project is the current mainstream mobile software ecosystem. This ecosystem is dominated by a small number of American technologies, which are known for collecting large amounts of data on users. They are closed-source and use proprietary data and standards, resulting user-‘lock-in’ and monopolizations of markets. Organizations in Europe are working to change this and to create a fair mobile software ecosystem that is pro-privacy and pro-openness, applying open-source principles and using open data and standards, contributing to digital sovereignty of Europeans. In MOBIFREE we bring together Europe’s leading organizations in this area to further develop Next Generation Internet (NGI) technologies to realize this.The Ambition of MOBIFREE is to support the digital sovereignty of European citizens and organizations by further developing open-source software that is human-centred and ethical, and by strengthening the ecosystem that provides these software solutions.  The broader Objective of MOBIFREE is to scale up mobile software technologies in all four key areas of the  mobile software ecosystem through co-creation and piloting with four key sectors of end-users, in order to improve the quality, privacy and openness of these software solutions, and create new business opportunities for the leading mobile software organizations in Europe making them.The Outcomes of MOBIFREE will include:   • More freedom for European citizens and organizations, who will get access to improved human-centred and ethical mobile software solutions that build upon the outcomes of the NGI-programme.   • New business and sustainability opportunities for the pro-privacy, open-source mobile software ecosystem in Europe and an expanding community of