RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ancient Maritime Pitch and Tar: a multi-disciplinary study of sources, technology and preservation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This intra-European fellowship places the designated researcher at the hub of a collaborative interdisciplinary project combining chemistry, archaeology, maritime history and conservation to advance understanding of the technology and use of pitch/tar products in Medieval Europe and to evaluate their stability in archaeological and museum environments. Analytical chemistry techniques will be used to research the sources and technology of pitch/tar from a number of medieval shipwrecks. Material from the recently excavated Newport Ship will be a focus for the study. This unique assemblage offers scope for the investigation of ship building techniques and repair strategies alongside examination of differential preservation due to burial environment. Interpretation of the Newport material will be supported by co-investigation of pitch/tar from at least four further wreck sites with differing preservation conditions enabling the impact of both intra and inter-site variability in burial environment to be compared. Production and ageing of pitch/tar materials under laboratory conditions will aid interpretation of the archaeological material and allow the stability of the materials in different environments to be systematically evaluated. This research will provide vital knowledge for improving approaches to the care of pitch/tar materials in museum collections. The researcher’s background in resin chemistry and previous experience of maritime archaeological material provide an excellent match for the project’s skill and knowledge requirements while offering plenty of scope for the acquisition of new competencies and broadening of experience. The host organisation offers a completely new form of working environment for the researcher and a multitude of opportunities for forging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Understanding death-receptor signaling and physiology in the nervous system: A roadmap for the development of new treatments to neurodegenerative diseases and neurotrauma'.

assistant: **Innovation**

The aim of this proposal is to elucidate the molecular mechanisms and physiological relevance of death-receptor signaling in the nervous system and to harness this knowledge for the development of novel treatments to neurodegenerative diseases and neurotrauma. The main focus is on the p75 neurotrophin receptor (p75NTR), which is predominantly expressed in the developing nervous system and is highly induced upon different types of adult neural injury. Additional studies on other death receptors, such as DR6, are also described. p75NTR signaling can induce neuronal death, reduce axonal growth and decrease synaptic function, hence there is a good rationale for inhibiting p75NTR in neural injury and neurodegeneration. Recent discoveries from my laboratory have clarified the mechanism of p75NTR activation and provided new insights into the underlying logic of p75NTR signaling, paving the way for a genetic dissection of p75NTR function and physiology. These discoveries have open new avenues to elucidate the molecular mechanisms underlying ligand-specific responses and downstream signal propagation by death-receptors, unravel the physiological relevance of death-receptor signaling pathways in health and disease, and develop new strategies to block death-receptor activity in neural injury and neurodegeneration.To drive progress in this research area it is proposed to: i) Elucidate the mechanisms by which p75NTR and other death receptors become activated by different ligands and elicit distinct, ligand-specific cellular responses; ii) Elucidate the mechanisms underlying the specificity and diversity of p75NTR signaling and decipher their underlying logic; iii) Elucidate the physiological significance of distinct p75NTR signaling pathways through genetic dissection in knock-in mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DNA Replication: From Physiology to Replication Stress in Human Cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Replication of the genome is of critical importance for cell proliferation and organismal development. To ensure accurate and complete replication of their genome, eukaryotes have hundreds to thousands of replication origins. In budding yeast, the genomic positions of all the origins are known, as is the order in which they fire. In contrast, in human cells, the mapping of origins is controversial and origin firing may be stochastic and plastic. Furthermore, while normal cells replicate their genomes with high fidelity; in cancer cells, the presence of activated oncogenes leads to collapse of DNA replication forks (DNA replication stress), DNA damage and genomic instability.My laboratory has recently elucidated key differences in DNA replication after oncogene induction. We mapped replication origins on the human genome and found that, in addition to the origins present before oncogene induction, a new class of “oncogene-induced” origins was observed upon activation of the CCNE1 (Cyclin E) or MYC (c-Myc) genes. Only forks from the oncogene-induced origins were prone to collapse, leading to the genomic instability patterns observed in the common human cancers.In this proposal, we aim to map with high precision the human replication origins, determine if their firing is stochastic or deterministic and identify sequence motifs that are important for origin firing (Aim 1). We further aim to explore how transcription in the G1 phase of the cell cycle regulates origin firing (Aim 2). This endeavour is motivated by our observation that transcription in G1 inactivates intragenic origins. Finally, we aim to understand how transcription, replication and repair are coordinated to avoid DNA replication stress in normal cells (Aim 3).The proposed experiments will help us understand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Exploring the origins and implications of variability in X-ray binary systems and active galactic nuclei'.

assistant: **Objectives**

Recent research has shown a deep connection between the X-ray variability properties of accreting black holes on all mass scales, from stellar mass X-ray binary systems (XRBs) to the similarly but much more slowly varying supermassive black holes in Active Galactic Nuclei (AGN).My research has suggested that the variability is due to variations in the accretion flow, which powers the emission from these objects. With a much deeper understanding of the nature and origin of the variability in XRBs we can shed new light on the nature of accretion and its importance for AGN variability.I will investigate XRB variability at a much deeper level and greatly increase my competence in XRB research by working at one of the world's leading institutes for XRB research, the Anton Pannekoek Astronomical Institute (API) in Amsterdam. I will use novel techniques, the rms-flux relation, flux distribution and bispectrum, to explore the origin of X-ray variability in XRBs and shed light on the nature of XRB states and the differences between neutron star and black hole systems.I will use my results to construct toy models for the variability which will shed light on variations in AGN accretion which occur on much longer time-scales than can be probed by observations, and may play an important role in the evolution of AGN and, through their interaction with their environment, the evolution of the Universe.Through exploring the new XRB/AGN synergy in a world-class XRB research group I will increase EU competitiveness in research in both AGN and XRBs, and reach a level of professional maturity which will enable me to pursue a fruitful research career in both AGN and XRB astrophysics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Combination therapy for the treatment of metastatic melanoma using magnetic nanoparticles'.

assistant: **Concept**

Metastatic melanoma is a hard-to-treat disease and it remains as one of the most worrisome cancer. There is an urgent need to improve the current therapies (chemotherapy, radiotherapy) that have a limited efficacy. A single therapy is not efficient to tackle metastatic melanoma and a combination of therapies is thus emerging as a necessity to efficiently eradicate all cancer cells. Recently, the development of immunotherapies has shown promises, in particular chimeric antigen receptor (CAR)-T cells. Nevertheless, the physical barriers represented by cellular and non-cellular components of the tumor microenvironment combined to the abnormal tumor vasculature and high interstitial fluid pressure, hamper an efficient tumour infiltration of CAR-T cells. In this context, thanks to a network of 18 partners (including 10 non-academic partners), MELOMANES aims to train doctoral researchers for the development of a combined therapy exploiting the properties of magnetic nanoparticles to induce damage on the tumor microenvironment by magnetic and optic hyperthermia in order to facilitate the infiltration of CAR-T cells. This therapeutic approach combining hyperthermia and immunotherapy is versatile, as it could be also applied to other types of solid tumors. Research and transferable training of the doctoral researchers will be performed in a highly interdisciplinary, intersectoral, and international environment. In addition to acquiring skills related to the research project, they will be trained also in open science, communication and dissemination, responsible research and innovation, circular economy, ethics, data management, entrepreneurship, marketing, intellectual property, and gender dimension in research. Their competences will be validated through certification and quali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Housing Precarity Pathways, Meanings, Influences and Responses among South Asian Migrants to Dublin', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Housing affordability and homelessness have been persistent problems both for Irish nationals and migrants over the last decade, but these problems are particularly acute among the latter. With the exception of those who are seeking asylum in Ireland, non-EEA migrants’ housing challenges have been largely ignored by policymakers in this country. The housing situation of non-EEA migrants has also received little attention from researchers and the factors which shape their particular housing problems are not well understood.  In particular neither the interaction between housing precarity and other socio-economic precarities which are more common among migrants (e.g. relating to labour market discrimination or legal status) has not been explored in depth, nor have migrants’ responses to these challenges and their agency in trying to shape pathways through these precarities. This research will fill these critical knowledge gaps by examining South Asian migrants’ lived experiences of housing precarity in Dublin, Ireland’s capital and largest city. The project aims to investigate South Asian migrants’ to Dublin lived experience of precariousness in terms of housing, labour market activity and immigration status and the interaction between these. The project marries the concepts of housing precarity, multiple precarities and structure-agency integration to guide a ground-breaking, multi-method anthropological study of these migrants’ precarity.  This innovative analytical framework goes well beyond the current state-of-the-art and has the potential to illuminate the precarity pathways of other marginalised groups in Ireland and internationally. By employing mixed methods (quantitative and qualitative), this project will examine the interaction between housing-related structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ammonium ion metabolism in cultured mammalian cells. Effects on energy metabolism and expression of recombinant complex glycoproteins' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The objective of this work is to develop strategies for controlling, in continuous mammalian cell lines, the expression of human-type glycoproteins used as biopharmaceuticals. Investigation will focus on parameters affecting the final oligosaccharide structure and hence the biological properties of recombinant human glycoproteins. The study is based on the novel hypothesis that the intracellular pool of UDP-N-acetylhexosamines (UDP-HexNAc) affects the expression of Nglycans. This pool is modulated by the culture environment, as both glutamine (via ammonium ion release) and glucose can contribute to it. Specific aims of the proposed project include: (a) Characterization of the effects of chemical parameters affecting UDP-HexNAc pool on the carbohydrate expression of a model glycoprotein produced by recombinant mammalian cells. (b) Evaluation of the effect of a shift in intracellular pH or culture temperature on carbohydrate expression. (c) Elucidation of the mechanisms responsible for changes in carbohydrate expression patterns resulting from changes in physical and chemical parameters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reconstructing cellular histories with transcriptional recording' (CRISPRhistory) under Horizon 2020.

assistant: **Objectives**

What are the main differences between a photograph and a video? Photographs record a single point in time and videos continuously record a sequence of events. While the content and interpretation of a photograph is heavily reliant on a single moment in time, a video is not. The tools that scientists have to understand the molecular and cellular world around them are most like film cameras – producing single snapshots to describe dynamic processes. Towards the goal of continuously recording molecular events within cells, my laboratory recently developed ‘transcriptional recording’, an approach that employs CRISPR spacer acquisition from RNA to capture and convert intracellular RNAs into DNA, permanently storing transcriptional information in the DNA of living cells. The newly acquired sequences serve as transcriptional records, which are retrievable via deep sequencing and can be leverage to reconstruct cellular histories. This technology provides an entirely new mode of interrogating dynamic biological and physiological processes and opens up numerous avenues for future work. The overall goal of this proposal is to develop transcriptional recording sentinel cells with the capacity to continuously monitor biological and pathological processes within the mammalian gut. To achieve this goal, we will employ a variety of methods that include molecular and cellular biology, synthetic biology, protein engineering, bioinformatics, and mouse models. We will focus our efforts on improving the efficiency of transcriptional recording, combining transcriptional recording with biosensing gene circuits, and demonstrating that transcriptional recording sentinel cells facilitate interrogation of the mammalian gut environment and can be applied as a living diagnostic. In summary, this st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Researchers' Night in Bosnia and Herzegovina 2020' (RiNG-20).

assistant: **Concept**

The European Researchers' Night in Bosnia and Herzegovina 2020 (RiNG-20) aim is to bring researchers closer to the general public and to shape deeper connection between research, creativity and entrepreneurship. RiNG-20 will be a flagship science promotion event in BiH while continuing to work on increasing awareness of research and innovation potentials in BiH, supporting public recognition of researchers and promoting achievements by local scientists and research-driven entrepreneurs, addressing research impact on people’s daily life, and encouraging young people to embark on research careers. Shortly, main objectives are: Enhance researchers’ public recognition; Increase awareness about research results, especially regarding the daily lives of citizens; Stimulate interest in research careers, in particular amongst young people facing a career choice.RiNG-20 slogan is “Discover Hidden Treasures”, dedicating 2020 edition to specifically highlight “hidden treasures” of Bosnia and Herzegovina – while focusing as much on natural as well intellectual resources of this country. RiNG-20 is a multidisciplinary STEAM event, aiming to highlight people in Science, Technology, Entrepreneurship, Arts and Makers in BiH and Western Balkan region. RiNG-20 is a science festival of national character, involving coordinated actions in at least ten cities in Bosnia and Herzegovina, and incorporates cross-border aspect by involving researchers and research-driven business from the Balkan region as participants in RiNG activities. RiNG-20 is aiming to reach over 1 million people during awareness raising campaign and involve at least 20.000 participants in the organized events during 2020 by implementing European Researchers’ Night in ten cities of BiH.


**Keywords:** European researchers'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart Trust: Secure Mobile ID for Trusted Smart Borders' under Horizon 2020.

assistant: **Concept**

Smart-Trust introduces a new technological enabler for Mobile ID which drastically increases the reliability and trust levels ofidentity verification at European borders, thus increasing the security of member states. The platform is compatible with aseamless self-service experience based on biometrics on the move which provides freedom of movements to citizens whileensuring their privacy safeguarded according to Privacy by Design principles.Smart-Trust will simultaneously address the business needs of governments, airports, airlines and border police in majorpilots in the international airports of Lisbon and Schiphol. After establishing requirements sought by the various stakeholders,and integrating the Smart-Trust platform into the airport and border control infrastructure, we will define KPIs for assessingthe business cases and design experiments to measure them.Smart-Trust will be implemented by delivering an agile, highly configurable, modular and open architecture platform with thefollowing robust, versatile and scalable core components:• Mobile ID services and app, mobile identity enrolment and verification services• TrustChain, a blockchain-based infra-structure to assert citizen transactions in a distributed and self-regulatory fashion• Workflow Orchestration, a workflow management component which caters for stakeholder-driven business rules• Analytics and Risk-Assessment, an industrial-strength real time analytics platform able to deliver professional customizedmonitoring dashboards as well as detecting passenger trends and anomalies.These components will be developed as part of Vision-Box’s overarching Services Platform and hence compatible withstandard Vision-Box services such as Automated Border Control, including Advance Passenger Information Systems (APIS