RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploiting fundamental insights of m6A methylation on CD8 T cell differentiation and function to boost medicinal T cell products' (M6ATCELL), addressing dissemination and exploitation.

assistant: **Impact**

Adoptive T cell therapies have revolutionised cancer treatment in some haematological tumours. Despite astounding advances, patients often relapse because the transferred T cells have low persistence and they lose their effector function against cancer cells. The prime challenge for improving T cell therapies is to decipher the mechanisms that define T cell effector function and memory formation. The MA6TCELL project aims to disentangle this problem by defining how m6A methylation on mRNA regulates human CD8 T cell differentiation and function. m6A is the most abundant mRNA methylation and determines gene expression by regulating mRNA metabolism, altering as such cell function. Using the miCLIP assay, I previously mapped genome-wide the m6A sites on the mRNAs of human CD8 T cells (unpublished data I will provide the host with). This map revealed that m6A occurs not only at the known DRACH sequences, but also at AU-rich sequences (AREs). Intriguingly, the host has uncovered that AREs are critical regulators of cytokine production in memory CD8 T cells (host expertise). My pilot experiments revealed that chemical inhibition of a m6A demethylase in CD8 T cells decreased cytokine production, further supporting my hypothesis that m6A methylation controls CD8 T cell differentiation and function. To test this hypothesis the M6ATCELL project will: 1) define the regulatory mechanisms of m6A methylation in human CD8 T cell differentiation and effector function and 2) test whether m6A enzyme inhibitors improve the potency of CD8 T cell therapies using chimeric antigen receptor (CAR) T cells. Our findings will yield fundamental insights in T cell biology, which can be relevant for multiple adoptive T cell therapies. My long-term aim is to transfer my scientific findings from bench-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nucleotide metabolism crosstalk in cancer: A single cell approach' to be submitted under Horizon 2020.

assistant: **Abstract**

DNA synthesis is essential for cell proliferation. Nucleotides, the basic building blocks of nucleic acids, are made by nucleotide de novo synthesis (DNS), and DNS disruption is detrimental to rapidly proliferating cancer cells. Established >70 years ago, anti-nucleotide therapy was one of the first approaches to treat cancer, but it suffers high rate of resistance and relapse. DNS can be bypassed by an uptake of extracellular nucleotides or by recycling in salvage pathways, possibly a reason for limited efficacy of anti-nucleotide therapy. To date, the cellular sources of nucleotides in normal tissue and in tumors in vivo remain poorly characterized. The central goal of this project is to define these nucleotide sources, understand the intercellular metabolic crosstalk of nucleotides in tumors, and characterize the adaptations to DNS blockade in cancer and stromal cells. To reach these goals, I will use the totally new perspective brought by the single cell technology and combine my expertise in single cell omics and metabolism with the state-of-the-art mouse models and advanced bioinformatics available at the host institute. I propose an integrative in vivo approach using single cell RNA-sequencing, which in combination with genetic interventions will allow me to resolve dynamic expression profiles of individual cell types. I will use inducible mouse models to selectively disable DNS in the stroma (lungs of a host animal) and in cancer cells (orthotopic tumors from syngeneic DNS-deficient lung cancer cells) to generate tumors fully relying on nucleotides from internal or external sources, respectively. In parallel, I will perform in vivo CRISPR screen to identify genes whose lack represents a targetable metabolic dependency of DNS-disabled cancer cells. This innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Emotional learning and extinction: integration of central and peripheral neural correlates' to be submitted under Seventh Framework.

assistant: **Abstract**

With a life-time prevalence of 25%, anxiety disorders are the most frequent psychiatric disorders and alone accounted for 147 billion Euros EU health care costs in 2004.The aim of this Marie Curie collaborative research project is to combine and share scientific expertise and shed more light on the dysfunctional neurocircuitry of anxiety disorders.Our current understanding has largely benefited from research on fear and fear learning. Indeed, it has been proposed that disturbed prefrontal cortex (PFC) functions as consequence upon a hyperresponsive amygdala (bottom-up) or/and a lack of PFC-amygdala top-down control are main reasons for affective disorders.In the present project we plan to further identify and disentangle underlying structures and temporal dynamics of both mechanisms using the integration of peripheral and central psychophysiological measures that allow for a millisecond resolution. Firstly, we will concentrate on the role of the PFC in early sensory processing of fear-relevant stimuli using an implicit fear learning paradigm. We propose that the PFC does not only play a part in late, but also in very early modulation of the neuronal fear response. Secondly, we will study how contingency awareness influences the strength of the CS-UCS association in fear conditioning. Using an explicit learning paradigm, both psychophysiological and neuronal correlates of fear learning will be investigated. At last, we will explore the biological basis of extinction learning and reappraisal, two approaches that play a major role in cognitive-behavioral therapy of anxiety disorders. We will study correlates of these processes in implicit and explicit learning tasks in order to study short- and long-term effects of therapeutic interventions.The basic hypothesis is that apa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Integrating Multiple Demands on Coastal Zones with Emphasis on Aquatic Ecosystems and Fisheries'.

assistant: **Objectives**

INCOFISH will conduct specifically targeted strategic research towards reconciling multiple demands on coastal zones.It will evaluate and integrate data, tools and concepts suitable to contribute to the goals set by the World Summit for Sustainable Development in Johannesburg, such as restoring healthy fish stocks and ecosystems by 2015. INCOFISH will focus its research activities on the following Integrated Coastal Zone Management  (ICZM) issues: document historical performance of ecosystems to deal with the 'shifting baselines' syndrome and provide sound reference points for resource restoration; provide electronic maps for all coastal species to establish authoritative species inventories and explore scenarios of global change and invasive species; create spatial ecosystem models for all coastal systems treated in this project as a basis for understanding the resource; provide guidelines and tools for best sizing and placement of marine protected areas; research impact of ecotourism on coastal ecosystem and provide best-practice guidelines; identify suitable simple indicators to promote and monitor sustainable fisheries; provide valuation of coastal ecosystem products and services and of different management regimes: review legal instruments for sustainable fishing in coastal zones; revisit coastal transects as a tool for structuring and understanding multiple demands on coastal zones; provide an archive and web portal for easy, public access to all data and tools relevant for ICZM.The tools and concepts resulting from INCOFISH research will be tested in real-world scenarios in selected coastal systems worldwide. They will  together form a package with the potential to impact on solving societal problems in the coastal zone in Europe and in developing countries.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coordination Action for Self-Awareness \nin Autonomic Systems' (AWARE) targeting Seventh Framework.

assistant: **Abstract**

The main aim of the AWARE Coordination Action is to provide a focal point for the wide range of research domains potentially addressed by the FET Proactive Initiative in AWARENESS. Self-awareness in autonomic systems can include ideas and concepts from artificial intelligence, network performance, distributed systems, machine learning, and artificial consciousness. This CA seeks to provide a common forum for cross-disciplinary interactions, by facilitating the exchange of ideas and personnel, by coordinating the development of the research projects and programme, and timely dissemination of research within the community and to a broader scientific and technological audience. The long-term purpose of these activities is to build a new, self-sustaining scientific community and the project will engage in a number of specific initiatives to bring this about. These will include workshops, summer schools, researcher placements, a periodical newsletter, a magazine, book, a video documentary, research consultations and other road-mapping, agenda-setting activities. A successful outcome of the project will include cross-fertilisation between different research domains, a gathering of scientists with a common purpose and training for an active group of well-informed, well-connected young researchers.   The resulting generation of new knowledge and opportunities will reinforce Europe's position at the forefront of this exciting and challenging field of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantum Molecular Photon Source'.

assistant: **Concept**

The development of a reliable photon source is vital for the development of new quantum technologies. There are many platforms currently being pursued to develop quantum simulators and quantum computers, but one point remains clear – photons will be required to allow such systems to talk to one another; they are the only logical choice for quantum communication due to their low decoherence, ease of encoding and the fact that they do not readily interact with each other. In this fellowship project I will combine cutting edge photonic device engineering and molecular single photon emitters to build a reliable, scalable photon source.  The organic dye molecule dibenzoterrylene (DBT) shows promise for use as a photon source with lifetime limited emission linewidths, a high quantum yield and an emission wavelength well matched to that of rubidium for interfacing with atomic quantum technology. I will interface these molecules with nanophotonic cavities and waveguides and utilise the advanced semiconductor fabrication capabilities of the University of York in a secondment phase to create novel, functional devices which will ultimately lead to the desired molecular photon source.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Centre of excellence in genomics and biotechnology improving functional traits of farm animals and quality of their products' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Centre was created at IGAB PAS. Mission of the project is: to ensure the Centre's position as a Coe in Genomic and Biotechnology research aimed at the improvement of farm animal functional traits, animal product quality and nutritional value and use of animal models in biomedical research; to establish regional network integrating institutions of CC performing research in the areas of molecular genetics and biotechnology of farm animals; integrating the Centre with ERA. The project's objectives will be achieved through the performance of the following activities: training of young Centre staff through a series of specialist lectures, organization of joint workshops with the participation of Advisory Board members and exchange of research personnel, scientific co-operation with EU laboratories resulting in the joint performance of FP6 research projects. The actions will result in significant increase of scientific level of the Centre.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Network for Using BIM to Increase the Energy Performance', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The building sector is the largest consumer of energy in Europe,  accounting for nearly 40% of the total consumption (EPBD 2010/31/EU). Furthermore the 2030 European Energy [COM(2014)16Final] and Energy Roadmap 2050 [COM(2011) 885 final], strongly requires more focus on the energy  efficiency on housing sector.Finally, the Directive 2014/24/EU of the European Parliament and of the Council on public procurement, requires that all member states introduce electronic means to exchange information and communication in procurement procedures. For these reasons we believe that the integrated approach of the Net-UBIEP project, based on Building information Modelling, integrated with energy  performance requirements, will be key to solve all the problems in a more effective and efficient manner.The project proposes BIM Qualification Models integrated with energy competences,  to  widespread a better comprehension of energy issues along all the value chain of building industry so that both existing and new building will have better energy performances.  Public Administrations, Professionals (Engineers /  Architects), Technicians (Installers / Maintainers) and Tenants will be therefore involved in the Net-UBIEP activities.The definition of the BIM Qualification Models will pass through the  identification of specific energy BIM competences for each of the above target needed to implement BIM models during the whole building life cycle.  During the project the “integrated” BIM Qualification Models will be validated by stakeholders thanks to the delivering of  different training activities (Seminars / Classrooms Courses /  E-Learning Courses) addressed to at least six BIM Professional Profiles: BIM Manager, BIM Evaluator, BIM Coordinator, BIM Expert, BIM facility manager, BIM user.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Imaging the Dynamical Imprints of Planet Formation in Protoplanetary Discs' under Horizon 2020.

assistant: **Concept**

The gas and dust discs around young stars are thought to be the birthplace of planetary systems and are a key area to study if further progress is to be made on understanding the history of our solar system and our own origins. Once planets have formed in these discs, they dynamically sculpt their environment, for instance by opening tidally-cleared gaps or triggering spiral arms and disc warps. The late stages of this process are likely observed in the “transitional” discs, where regions spanning tens of astronomical units (AU) have been cleared. The aim of this project is to image the planet formation signatures both during the transitional disc and the earlier T Tauri or Herbig Ae/Be stars phase, where the protoplanetary bodies are just starting to carve gaps in the optically thick disc. For this purpose, we will employ the latest generation of near-infrared, mid-infrared, and sub-millimeter interferometric instruments that will allow us to trace a wide range of stellocentric radii, disc scale heights, and dust opacities. We will make use of recent revolutionary advancements in infrared detector technology and equip the CHARA/MIRC 6-telescope beam combiner with a low-read noise camera that will significantly increase the sensitivity of this instrument and enable us to image protoplanetary discs with 2.5 times higher resolution and much higher efficiency than ever before. These quick-look imaging capabilities will enable us to trace time-variable structures in the inner few AU and to investigate their relation to the commonly observed photometric and spectroscopic variability. Our interferometric observations in spectral lines aim to detect the accretion signatures of the young protoplanets themselves. Employing sophisticated radiation hydrodynamics simulations we wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CONverging TECnologies and their impact on Social Sciences and Humanities', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

This project addresses the potential roles that the social sciences and humanities (SSH) can play with regard to phenomenon of technological convergence (between Nano-, Bio-, Information technologies, Cognitive sciences and Social sciences and Humanities), its shaping and ethical and societal implications. In an integrated and systemic approach the project explores the major ethical and societal questions raised by technological development in the field of converging technologies (CT) and the ways in which these can be addressed by the Social Sciences and Humanities. In the context of imminent transformations to a European knowledge-based society, these questions present key opportunities and challenges, which the research community needs to be prepared to face. This activity will build on a continuous review and monitoring of technological developments in the CTs and relevant global RTD policy trends, at the same time analysing their possible implications for contributions by the SSH.The project will further analyse how and to what extent the SSH can contribute to the shaping of science and technology. The final aim is to raise awareness of Converging Technology issues throughout the SSH community and to develop options for a research agenda to be implemented in the SSH priority of 7th Framework Program. The emergence of the knowledge-based society will entail new forms of relationships between its citizens, on one hand, and between its citizens and institutions, on the other. The project aims to mobilise European research capacities in SSH that are necessary to develop an understanding of, and to address issues related to, this critical phenomenon.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of cdna-arrays for quantifying expression levels of mrna and oligo-arrays for detecting genetic variants of drug metabolism genes: pharmagenarrays' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The scientific goals of the proposed prom act are:1) To develop a array-array system to profile expression levels of drug metabolising enzymes after exposure of cell cultures or whole animals to xenobiotics (drugs or environmental compounds) and2) to develop an oligonucleotide-array system to detect variant alleles of genes that determine an individuals response to medicinal compounds (drugs) or determine an individuals risk on exposure to environmental toxins. Expression profiling of drug metabolising enzymes in animals and later in humans is a key component in the pre-clinical stages of new drug development in the pharmaceutical industry. Detection of variant alleles (genotyping), the second objective of the proposed collaboration, will address an emerging and far-reaching need in the pharmaceutical industry and in healthcare in general. The ultimate goal of this second objective is to develop a cost-effective method of pharmacogenetic profiling for use as a tool in clinical trial studies and in the longer term as a means of selecting the lost aoorioriate drug therapy for individual patients.