RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Adjustment & deformation analysis of Thixotropic microstructures of Steels', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content Thixoforming means the material deformation in the semisolid state, where the material is partially molten and the solid particles are surrounded by the liquid phase. Therefore the process can be classified between casting and massive metal forming and enables the manufacture of complex shaped parts with very small forming forces. Current works mainly focus on the processing of light metals, like aluminium alloys, and have lead to the manufacture of application parts. Due to the superior technical properties of steels, Thixoforming of these materials is of high economical interest and will create new markets: steels can substitute light metals in many constructions, since thixoformed parts of steel have equal complex shapes, however superior strength properties and therefore can be designed smaller in dimension. Furthermore, due to the strongly increased deformability of the material in the semi-solid state, thixoformed parts can be manufactured in one forming operation at low forming forces, therefore less forming tools are required, less material is utilised and less energy is consumed. Until today, no comprehensive basic data for the Thixoforming processing of steels exists and therefore prevents the realisation of industrial applications. It is not known,  Which steels of industrial relevance can be used for Thixoforming?  How suitable starting materials can be manufactured?  How a heating process in the semi-solid state is to be designed?  Which deformation parameters must be used for the forming process? This data is required, if an industrial application of Thixoforming of steels shall be realised. This data shall be provided within this Basic Research project and will be the basis for future developments to transfer the project results to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design Global, Manufacture Local: Assessing the Practices, Innovation, and Sustainability Potential of an Emerging Mode of Production' in the context of a Horizon 2020 call.

assistant: **Objectives**

COSMOLOCALISM will document, analyse, test, evaluate, and create awareness about an emerging mode of production, based on the confluence of the digital commons (e.g. open knowledge and design) with local manufacturing and automation technologies (from 3D printing and CNC machines to low-tech tools and crafts). This convergence could catalyse the transition to new inclusive and circular productive models, such as the “design global, manufacture local” (DGML) model.DGML describes the processes through which design is developed as a global digital commons, whereas the manufacturing takes place locally, through shared infrastructures and with local biophysical conditions in mind. DGML seems to form economies of scope that promote sustainability and open innovation while celebrating new ways of cooperation. However, such claims rest on thin conceptual and empirical foundations.COSMOLOCALISM is a multiphase, pilot-driven investigation of the DGML phenomenon that seeks to understand relevant organisational models, their evolution, and their broader political economy/ecology and policy implications. Through the lens of diverse case studies and participatory action research, the conditions under which the DGML model thrives will be explored.COSMOLOCALISM has three concurrent streams: practices; innovation; and sustainability. First, DGML practices will be studied, patterns will be recognised and their form, function, cultural values, and governance structure will be determined. Second, the relevant open innovation ecosystems and their potential to reorient design and manufacturing practices will be examined. Third, selected DGML products will be evaluated from an environmental sustainability perspective, involving both qualitative and quantitative methods. The interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human hereditary deafness - identification of genes, molecular diagnostic tests, epidemiological data, understanding pathogenesis and search for therapies' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to address the needs of deaf patients 22.5 individual in the eu. By performing resaerech wich will lead to high quality genetic counselling and the discovery of curative treatements. To fulfil these expectations a number of human deafness will be isolated and moleculare daignastic test associated with a detailed clinicale description of the differnt gene defect will be developed. The major challenge i.e. the development nof new therapies will be tackled direclty as well as by elucuidating the underling dfective patwaays. To achieve this conplementary approaches will be set up and mouse and zebrafisch model for human daefness will be generated witch much effort on the connexin 26 gene defect 50% of congenitale deafness .the role of daefness gene in the susceptibility to environmentale causes of hearing loss .i.e. to noise and aminoglglycosides will be also analysed. Finally the consortium will produce epidemiologicale data on hereditary daefness in the eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Water management, land development and economic diversification in southeast asian deltas'.

assistant: **Innovation**

The project aims at comparing irrigation and drainage management systems, both on institutional and technical points of views, that are presently performed in the three main deltas of South-East Asia (Red River delta and Mekong delta in Vietnam and the Chao Phraya delta in Thailand). This includes :* comparing existing practices of water management (irrigation, drainage) in the three deltas,* evaluating their consequences on economic efficiency and on constraints for further land development,* identifying conditions and results of one common pattern of diversification (poldered raised beds system),* propose new patterns of water management.Expected OutcomeThe concrete achievements should include models for water management in the deltas, an improved efficiency of water distribution, feasibility of change in water allocation and management, with water saving, the assessment of the causes and consequences of the agricultural diversification, and a complete set of technical references on raised beds systems. A special attention will be paid in the project to design  easy to understand " IEC (Information, Education and Communication) documents. This joint project constitutes the cornerstone of a regional network on deltaic agriculture.The key activities will include three research packages :* The first package will deal with comparing different water management institutional designs that do exist (or have existed in the recent past) in the three deltas, at studying the interaction between actors in the successive levels of decision found along the water chain and at evaluating the water cost according to the different designs that have been identified: definition of the respective powers and responsibilities of the institutions involved, impact on financial issues, particul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Versatility of scaffold complexes in vivo to control synaptic plasticity' in the context of a Horizon 2020 call.

assistant: **Objectives**

Receptors and associated scaffolds, together called receptosome, are relatively stable structures, but exchange of individual adaptor proteins can occur on a short time scale and in a highly regulated manner, which provides fine-tuning, speed, and specificity to the receptor signaling. Therefore, understanding how receptor function is affected by the composition and dynamics of complexes is an essential biological concern that will offer the opportunity to target exclusively the therapeutically relevant signaling pathway of a given receptor. We propose that in the brain, receptosome dynamics is involved in fine-tuning synaptic transmission and plasticity, which might be crucial for cognitive functions.First, we will establish the link between molecular events, neuronal signaling and memory performance. More than correlations, this project proposes live recording of molecular events and cellular signaling during memory encoding. Second, new specific therapeutic targets will be proposed for the treatment of cognitive deficiencies: instead of interfering with the ligand-biding pocket of the receptor, we propose to target specific scaffold interactions. This strategy will only modify a specific altered function of a receptor without modifying other functions (thus, avoiding undesired side effects). Third, within the scope of this proposal, we will develop innovative, powerful techniques that will be of high interest for a broad community of researchers in life sciences. These technologies will enable to monitor the versatility of protein-protein interactions in space and time ranging from in cellulo to in vivo BRET imaging in freely behaving animals. To conclude, we will establish the functional significance of oligomer remodeling in the physiological synaptic plasticity an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In-situ & operando organiC electrochemical transistors monitored by non-destructive spectroscopies for Organic cmos-like NeuromorphIc Circuits' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Ultra-flexible, conformable and implantable artificial intelligence organic electronic devices hold promise to revolutionize the real-time monitoring and treatment of chronic diseases. Such devices are based on organic electrochemical transistors (OECTs) exploiting polymeric mixed ion-to-electron conductors (PMIECs) as active layers. However, the development of efficient and stable devices is hindered by limited knowledge about structure-property relationships of PMIECs.ICONIC combines macromolecular synthesis with in situ and operando non-destructive spectroscopic methods in an innovative way to investigate with unprecedented accuracy ion-to-electron transduction in OECTs, from the molecular to the micrometre scale. This provides the key knowledge to make a technological leap in development of smart therapeutic devices.As a proof of concept, ICONIC develops an intelligent closed-loop device for drug-delivery activation. In a long-term vision, healthcare devices will enable signal recognition with body-friendly electronics and administer medication without the risk of human error.ICONIC is a multidisciplinary high-risk/high-gain project engaging 8 partners from 6 countries covering the academic and industrial worlds (including 1 SME). The implementation is facilitated through 4 work packages (3 technical). The complementary scientific skills brought in by the partners and stakeholders maximizes ICONIC’s impact.


**Keywords:** Polymeric Mixed Ion-to-Electron Conductors; Organic ElectroChemical Transistors; non-destructive spectroscopies; organic neuromorphic circuits; iontronic pump; closed-loop & predictive device
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Computational Fluid Dynamics simulation of the flow around an ultrasonically oscillating instrument', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Irrigation of the root canal with antibacterial solutions is indispensable during root canal treatment in order to remove biofilm, tissue remnants and dentin debris from the root canal. Nonetheless, still 50% of the root canal treatments fail as a consequence of poor cleaning. Ultrasonic activation of the irrigant has been shown to dramatically increase cleaning efficiency. A full understanding of the fluid dynamical action of the activated fluid is crucial for the improvement of treatment success. Previous experimental approaches have failed to provide complete insight into this procedure, due to the difficult temporal and spatial scales of the flow and the geometrical complexity of the root canal. The objective of this proposal is to employ Computational Fluid Dynamics simulation in order to study the ultrasonic activation of the irrigant in the root canal. A combined Endodontology - Fluid Dynamics approach is proposed. The researcher has introduced the use of Computational Fluid Dynamics to the field of Endodontology and has been recently awarded a Doctorate Degree. He will move from his home institution (Dept. Endodontology, Thessaloniki, Greece) to a world leading group in Fluid Dynamics, biomedical and micro-fluidics applications (Physics of Fluids Group, Enschede, The Netherlands). The researcher will acquire additional experience with numerical simulation of flows inside micro-channels as well as experimental high-speed imaging techniques, which will be used for the validation of the computer model. Following successful completion of this fellowship, he will become able to lead his own scientific group on biomedical engineering in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'IMaging Ocean Sinkers for evaluating carbon export fluxes' (IMOS).

assistant: **Innovation**

It is becoming increasingly evident that small changes in the efficiency of the Biological Carbon Pump BCP can significantly alter ocean carbon sequestration and, thus, atmospheric CO2 and climate. Despite their importance, the factors that drive the BCP variability are poorly understood. As a consequence, current annual global estimates of the magnitude of carbon (C) export from the surface ocean via the BCP vary up to 400% (from 5 to 21 Gt C yr-1). IMOS will focus on increasing the precision of the export assessments and restraining the variability by taking advantage of some of the most promising technological advances in in-situ imaging and autonomous sampling combined with state of the art methods and powerful simulation tools. Specifically, IMOS will use particle imaging with high resolution underwater cameras, UVP (Underwater Vision Profiler) type, which will be combined with a uniquely modified autonomous float to allow for the first time simultaneous in-situ particle imaging and sinking particle collection. The overall research objective is to link optical properties to direct C flux measurements to obtain higher resolution quantification of C export in the oceans via the BCP.The fellow will spend the first 2 years at the Woods Hole Oceanographic Institution (WHOI) under the supervision of Dr. Ken Buesseler. The last 12 months will be spent at the Universidad de Sevilla (USE), under the supervision of Dr. María Villa-Alfageme.  She will return to Europe with the technical expertise required to work with unique field measurements and develop improved global parametrizations of the BCP efficiency, which are key areas of expertise for describing the present and future role of the BCP in global climate models. Research results will be of interest to worldwide resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Human TSLP and OX40L as targets of therapeutic intervention for allergic asthma' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Epithelial cell derived Thymic Stromal Lymphopoietin (TSLP) instructs dendritic cells (DCs) via the expression of OX40L to induce Th2 polarization and is both necessary and sufficient for the development of airway inflammation. TSLP and OX40L are therefore promising targets for the development of new therapies for allergic asthma. The aim of this project is to study the potential of targeting human TSLP and human OX40L for intervening with the initiation and/or progression of allergic asthma in vivo, using a humanized mouse for asthma model. The proposed model is unique since it enables to particularly evaluate the effect of potential therapeutic compounds, in our case (anti-)TSLP and (anti-)OX40L, on human haematopoietic cells in an in vivo system. Information acquired in this project should therefore lead to important go-no go decisions to further advance this therapeutic strategy to the clinic. All experimental work will be performed in the laboratory of Prof. Bart Lambrecht (University Hospital, Ghent, Belgium). Prof. Bart Lambrecht is an expert on murine models of asthma and is focused specifically on DC biology. In his laboratory all facilities and expertise are available to perform the proposed experiments. In addition, the group heads have extensive experience in mentoring and guiding post docs. The proposed work will allow me to further develop my recently founded translational research line directed at the immunopathology of allergic asthma in young children. On return to my home institute I will incorporate my research in the Center of Molecular and Cellular Intervention of the University Medical Center Utrecht (head Prof. B. Prakken). The combination of my current expertise in human immunology, my clinical expertise as an MD-pediatrician and the expertise I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SINGULARITY: The first quantum software toolbox for finance'.

assistant: **Concept**

Quantum computers are reaching a scale where they can start delivering value. The quantum software market is estimated to grow at a CAGR of 42% over the next five years to reach €1.42 billion by 2027. McKinsey highlighted finance as the earliest high-impact application of quantum computing. We have been pioneers in this space. We authored one of the seminal papers in the field. Then we developed a quantum software toolkit for finance, and results from beta testing with leading financial institutions brought us to the limelight. Now, thought leaders like McKinsey, The Economist, BCG, and Forbes point at Multiverse as a leading firm in quantum finance. Quantum computing is a strategic technology for Europe. Anglo-Saxon firms dominate both quantum and finance. Yet, Multiverse is leading this race. However, we must act decisively to keep this position. With the EIC support, we will keep the lead and materialise the promise of quantum for financial applications.


**Keywords:** Quantum computing,Finance,Quantum for finance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Establishment of a Regional Center of Competence for VVER Technology and Nuclear Applications' (CORONA) targeting Seventh Framework.

assistant: **Abstract**

The essence of the project is to provide a special purpose structure for training and qualification of personnel for serving VVER technology as one of nuclear power options used in EU. Such approach should allow unifying existing VVER related training schemes according to IAEA standards and commonly accepted criteria recognized in EU. The structure is based on three general pillars: 1) Training schemes for VVER nuclear professionals; for non-nuclear specialists and subcontractors, involved in nuclear sector; and for students; 2) VVER related knowledge management system, which will accumulate information regarding design data, operational experience, training materials, etc.; and 3) Specialized regional training center for supporting VVER customers with theoretical and practical training sessions, training materials and general and special assignment training tools and facilities. The wider objective of the project is to implement the Council Conclusions of 1 - 2 December 2008 related to skills in the nuclear field: new skills and competences are needed in the context of the Nuclear Renaissance and to fulfill obligations under Article 7 of the COUNCIL DIRECTIVE (EURATOM) establishing a Community; framework for the nuclear safety of nuclear installations. The specific objectives of the project are: - enhancing safety and performance of nuclear installations with VVER technology through specialized initial and continuous training of personnel involved; - keeping the adequate level of safety culture; - contributing to the development of Knowledge Management System for VVER technology; - preserving and further developing nuclear competencies, skills and knowledge related to VVER technology, as a technology used in the EU.