RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of high-sensitive and high-throughput molecular tools to disentangle the mechanisms of heavy metals accumulation and tolerance in mosses: epigenetic and transcriptomic approaches' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The anthropogenic emission of heavy metals (HM) into the atmosphere constitutes a major social and environmental concern. Poor air quality is a major health risk (in 2010, more than 420,000 people were estimated to have died prematurely from air pollution in the EU) and has also considerable economic and environmental impacts, affecting the quality of fresh water, soil, and ecosystems [http://ec.europa.eu/environment/pubs/pdf/factsheets/air/en.pdf]. Though several regulatory steps have been implemented within the EU to reduce or restrict the release of pollutants in the air, e.g. [Council Directive 96/62/EC], and also to monitor/model them [Council Directive 2004/107/EC], more work is needed to progress in the characterization of the relationship between living organisms and environmental pollution. Therefore, BRY“O”MICS will provide a deep understanding of the mechanisms underlying the existence of phenotypic variability for heavy metals tolerance and hyperaccumulation in mosses (which differ from those in higher plants), as well as the necessary background knowledge to subsequently develop high potential biotechnological tools for air quality remediation (focusing mainly in urban and indoor environments). This will be achieved by means of the integrated use of various tools from several biological disciplines such as ecophysiology, chemistry, microscopy, transcriptomics, epigenomics and bioinformatics. The most innovative part of this project lies in the application of the “omics” technologies to a novel and under-researched context: wild populations of terrestrial mosses growing in heavy metal enriched areas. Additionally, the integration of the results obtained from the former disciplines will highly improve the conclusions achieved with this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A multivariate platform for assessing the impact of strategic decisions in electrical power systems' (CASSANDRA).

assistant: **Innovation**

Energy markets have undergone fundamental changes at the conceptual level over the last years. The necessity for sustainability has transformed the traditional power production scheme to a distributed energy resource one, while the future points towards a great number of decentralized, small-scale production sites based on renewable energy sources, also. The Smart Grid paradigm is here to stay, while the deregulation of energy markets has defined new rules and new procedures.These changes offer substantial opportunities for all energy market stakeholders, which remain mostly unexploited due to two main reasons: a) the small-scale consumers comprising the vast majority of stakeholders are individually insignificant, and their market power is practically non-existent. Nevertheless, if they were somehow aggregated, their market power would dramatically increase, so as to affect market related policies and, b) there is currently a lack of tools for modeling this aspect of the energy market, i.e. the modeling of all involved entities with respect to their consumption behavior in an aggregate fashion, and the evaluation of trends formulated, policies applied and decisions made against specific socio-economic and environmental performance indicators.Project CASSANDRA aims to build a platform for the realistic modeling of the energy market stakeholders, also involving small-scale consumers. CASSANDRA will not provide another tool for visualization. Rather, it will provide users with the ability to test and benchmark working scenarios that can affect system operation and company/environmental policies at different levels of abstraction, starting from a basic level (single consumer) and shifting up to large consumer areas (i.e. a city). The project main outcomes will be the aggre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Analysis of “difficult” proteins by microfluidic-based hydrogen/deuterium exchange' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Many proteins important in biology or disease are not amenable to traditional methods for structural analysis as they cannot be isolated in sufficient amounts nor studied directly in their native environment. Alternative techniques are needed to understand the conformation and interactions of such difficult proteins and further support the on-going shift to protein-based ‘biopharmaceuticals’ in the pharmaceutical industry. One promising technique to meet this challenge is the use of mass spectrometry to measure the hydrogen/deuterium exchange of proteins (HDX-MS). However, HDX-MS suffers from significant limitations to realize its full potential and applicability.  HDXchip aims to develop innovative microchips to revolutionize the HDX-MS method and enable analysis of difficult protein systems of unprecedented complexity. HDXchip will create “HDX-MS 2.0” technology that integrates on-chip sample treatment and separation to overcome major limitations of the conventional method, including virtually eliminating unwanted deuterium loss (back-exchange). The key to fabrication of HDXchips lie in the fact that all elements will be made of thiol-ene polymers. These polymers are not only used to make the chip itself in a cheap and simple manner, but also to fabricate high surface area functionalities for fast sample treatment (incl. enzymatic reactions) and separation at unprecedented efficiency. HDXchip will enable step-change improvements in popular HDX-MS applications, like analysis of the conformation and interactions of purified proteins and also open up for exciting and hitherto unfeasible applications such as analysis of proteins inside whole cells and proteins in their native lipid membranes. Hence, HDXchip could enable breakthrough insights into the conformation of diffi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Technologically Enhanced European Wood for Substituting Endangered Tropical Woods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Many tropical woods are highly esteemed for making musical instruments and for making high quality cues for billiard sports, owed to their excellent physical properties, such as high hardness, resistance to moisture, acoustics. However, they suffer from overexploitation, which has led to severe ecological (climate change), economical (disappearance of classical occupations, trade restrictions), political (piracy, corruption, illegal trade), cultural and societal consequences. In order to counteract the extinction of tropical forest more than 180 countries have increased their efforts to fight against the illegal logging and trade of tropical woods (CITES). Consequently, trade of and travelling with tropical wood containing goods is being strictly controlled and prosecuted in the absence of a legality proof. This results in a pain for both B-to-B customers as well as the end-customers (e.g) musicians. To solve these problems, there is an urgent need for sustainable alternative materials to replace the tropical woods. Swiss Wood Solutions AG (SWS) has developed a real wooden substitute material –the Swiss Ebony Line, a technologically enhanced wood material made of European wood species from certified sustainable forests. The product line features similar or even better physical properties (such as hardness, density, acoustics) than the natural tropical woods. The objective of the project is to upscale the established process in terms of product dimensions (size) as well as annual production volume, in order to enter the markets of bigger stringed musical instruments (guitars, cellos etc.) marimbas and the market of cue sports. Furthermore, a comprehensive market analysis for application fields and intensive marketing activities are the other important project objectives,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Self Reporting Asymmetric Nucleophilic Catalysis' (SRANC).

assistant: **Innovation**

The energy efficient synthesis of complex molecules from readily accessible starting materials remains a key challenge of the natural sciences, catalysis can address this important challenge. This project draws together the disparate disciplines of catalysis and sensing to deliver new understanding and new functionality towards the synthesis of the next generation of molecules for health. By exploiting the best technology in the sensing arena in combination with synthetic expertise will offer a new paradigm in the approach to tackling synthetic challenges that the team draw together here is ideally equipped to tackle and deliver significant scientific and societal benefits.New catalysts which can sense their own efficacy will be at the heart of the proposed research. Through rapid screening facilitated by the unique sensing regime translated from chemical sensors into catalysis will permit new and exciting synthesis be realised. As such drug molecules that were previously inaccessible for commercial exploitation due to efficiency and selectivity concerns will be realised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Wnt Enhancer LandscapE CharacTerization'.

assistant: **Concept**

Despite significant efforts, cancer remains one of the major health challenges in Europe.In essence, cancer can be seen as the result of alterations in the intricate balance between cell proliferation, differentiation and death during tissue homeostasis. Hence, pathways that are essential for the development and maintenance of mammalian tissues are frequently deregulated in human tumors and represent attractive targets for therapeutic intervention.In that respect, the Wnt signal transduction pathway serves as a paradigm: On the one hand, Wnt ligands are crucial determinants of cell fate decisions and can act as self-renewal factors for adult stem cells in multiple tissues, including the mammary gland. On the other hand, aberrant activation of the Wnt/beta-catenin pathway is a hallmark of many human (breast) tumors.While it is clear that Wnt activity has to be carefully coordinated in precise temporal and tissue-specific patterns, there is a significant knowledge gap regarding the underlying control mechanisms.In this project, I will combine bioinformatics, state-of-the-art genome engineering and an innovative screening approach to identify Wnt-associated enhancers in the mammary gland.I aim to:1. Establish an effective experimental pipeline for an epigenetic screen.2. Identify functional regulatory sequences for almost half of the mammalian Wnt genes.3. Validate individual enhancers in vivo.The proposed research together with the training I will receive in an excellent, multidisciplinary research environment will significantly benefit my scientific career development.Finally, I envisage that my results will provide the basis for uncovering how environmental and intrinsic signals are integrated to control dynamic Wnt expression patterns in both normal development and can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Adaptation to Recurring Fasting by Chromatin-Mediated Memory' (MemoChrom).

assistant: **Concept**

Adaptation to recurring environmental challenges (food availability, seasonal rhythms etc.) is a mainstay of physiology. As such, mammals are exquisitely fitted to tolerate frequent bouts of fasting owing to hepatic production of fuels (glucose, ketones).  Indeed, studies show significant health benefits of intermittent fasting. Due to the reliance of the fasting response on chromatin and transcriptional regulation, I hypothesize that mammals adapt to recurring fasting by sensitizing transcriptional programs and maximizing future responses, thereby increasing survival. I plan to uncover transcriptional mechanisms of ‘fasting memory’ that mediate the health benefits of recurrent fasting. I will profile the hepatic transcriptome and genome-wide chromatin landscape of intermittently-fasted mice to discover the mediators of such memory. I will evaluate three plausible mechanisms: (1) Enhancer priming whereby the DNA regulatory elements dictating gene expression are kept in a primed state between fasting episodes. (2) Promoter priming in which RNA polymerase is paused at gene bodies during feeding and rapidly released upon re-fasting. (3) Transcriptional cascades whereby genes induced in the previous fasting bout are active in the next one, directing a second wave of gene expression. The molecular mechanisms mediating memory will be examined in a series of gain/loss of function experiments targeting various components of transcriptional regulation (transcription factors, RNA polymerase, histone and DNA modifications etc.). Both the notion of fasting memory and the cellular mechanisms driving it are supported by preliminary results. The concept raised here has the potential to unravel a fundamental homeostatic response and significantly advance fasting research. More broadly,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Digital Open Marketplace Ecosystem 4.0' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The Digital Open Marketplace Ecosystem (DOME) 4.0 aims at developing a comprehensive industrial data ecosystem aligned with the Open Science and Open Innovation objectives to enable sharing of business-to-business (B2B) data for the purpose of value generation and creation of new or enhanced products, processes, and services. DOME 4.0 will be open to all providers and users of data, and aims to facilitate maximum knowledge extraction with the help of ontology-driven semantic data interoperability and modern data processing technologies adopted from the fields of Machine Learning (ML) and Artificial Intelligence (AI). These features are crucial to scale and advance the proposed ecosystem to any sector of the economy. Given the significant contribution of the materials and manufacturing sectors to the European economy, DOME 4.0 focuses on data-driven knowledge generation within these key sectors. The project duration is four years and will focus on two parts: a) core ecosystem technology advancement with connectors to other marketplaces, data and knowledge bases; and b) demonstration of added value via nine B2B success stories covering areas such as nanomaterials, manufacturing equipment and processes, lightweight construction,  etc., while dealing with data characteristics such as quantity, quality, velocity, formats, and sources. Data governance, sovereignty, provenance and adherence to FAIR principles are proposed.True to its ethos, DOME 4.0 offers a scalable, convergence mechanism to the vast array of research and innovation activities undertaken within the Horizon 2020 programme. The project coalesces the key H2020 developments from multiple marketplace projects, open simulation platforms, open translation environments, industrial networks, data platforms, and Coordi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Firwat net Fuerscher? (Why not researcher?)'.

assistant: **Innovation**

The Researchers in Europe Initiative" and the launching event by the European Commission of the initiative in June 2005 under Luxemburg?s presidency of the European Union have been the occasion to bring together partners from various backgrounds (educatio n, higher education, research, promotion of scientific culture) to start a campaign in order to promote the researcher?s profession. In Luxembourg, the majority of public and private research institutes developed their research activities very recently, since the late 1980s. The media and the general public are not really aware of the importance of scientific contributions or researchers? contributions to both, society and economy. Indeed the lack of a scientific journalism, as it is practiced in other Eu ropean countries (existence of popular periodicals, television magazines ?) led to the opinion that research activities seem to be carried out only by big foreign research institutes and that scientific research only happens outside Luxembourg. Consequentl y, most of the young people in Luxembourg think that the profession of a researcher does not offer real perspectives for the future. It is not considered as a serious alternative in the choice of a professional career. Other phenomena still have to be ana lysed, like the downward tendency of inscriptions in physics, mathematics, engineering and natural sciences. The consortium of partners under the present call suggests a coordination and promotion campaign to improve the awareness of the researcher?s prof ession as a real career option, comprising : ·new activities in collaboration with the most important media in Luxembourg to promote the researcher?s profession ·many existing activities that could be better coordinated with an increased visibility to th e general
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COMFUTURO, a public-private collaboration committed to science and the future' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ComFuturo is a public-private collaboration initiative managed by Fundación General CSIC (FGCSIC), which has had 4 successful previous calls for young researchers at the national level. Now, FGCSIC wants to expand ComFuturo, attracting international talent, through a comprehensive programme that includes quality training and research secondments. This 60-month programme will offer 15 ComFuturo 36-month fellowships to Experienced Researchers (ER) of any nationality who have obtained their PhD in the last 10 years. The “ComFuturo fellows” will be selected through a single call and an objective and transparent process, which will include an external evaluation by the Spanish State Research Agency. FGCSIC has teamed up with 7 partner organisations (PO). The Spanish National Research Council (CSIC) will recruit, hire and host the ER. ComFuturo research areas will include those aligned with the United Nations Sustainable Development Goals (SDG) that contribute, from any scientific-technical discipline, to fulfilling the 2030 Agenda; and topics proposed by PO (in consensus with FGCSIC), that help respond to strategic challenges of the productive sector. ComFuturo aspires to generate, via the promotion of highly innovative projects and science of excellence, an impact on the sustainability of the productive fabric, the environment and society. ComFuturo fellows will freely propose their research projects and their host CSIC centres. They will carry out industrial and international secondments and it will be ensured that they all have the same opportunities and can benefit from the interdisciplinary, intersectoral and international nature of the programme. ComFuturo aims to contribute to obtain a generation of researchers who are leaders in their fields of specialization, but at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanoscale Digital Microscope' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The NanoXim project proposes a disruptive nanoscale holographic microscope with a sensing architecture that can compensate for the lack of complexity of usual optical components (confocal) or markers (fluorescent) by use of novel theories and numerical algorithms. The technique based on digital holography allows to realize 3D movies with sub-µm resolution. The instrument developed CEA builds phase contrast maps of a specimen by using 3D propagation and numerical reconstruction algorithms already implemented in a user-friendly interface. We propose realize a study of the a large panel of end-users and also to validate immediate needs and requirements in health problems and bio-technology. First objective consists in supporting CEA to bridge the gap from research prototypes to the pre-commercial products and initiate the creation of a start-up. We will increase of the technology readiness of the instrument. TEMATYS SME will support this by bringing a market analysis and set a full business model. We will seek for valorization through patenting and licensing to put the instrument close to the market. A startup creation willbe initiated.