RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Gender Discrimination in the Tarim Basin' (GENDISC).

assistant: **Innovation**

The Tarim Basin in the Xinjiang Uyghur Autonomous Region of China was strategic on the ancient Silk Road. Expeditions by European explorers in the 19th and 20th centuries found ruins of ancient oases settlements around the circumference of the Taklamakan Desert. Amongst the ruins were artefacts, many documents and manuscripts written in different scripts and languages, some previously unknown. All attest to the cultural, religious and ethnic diversity of the region. The focus of GENDISC is on the Niya Documents, a collection of approximately 1000 documents and document fragments dating to around the 3rd century CE found around the southern Tarim Basin, but mainly around the Niya ruins. Three-quarters of the documents were written in the South Asian Kharosthi script and Gandhari language, earlier used in ancient Pakistan, Afghanistan and north India for inscriptions, manuscripts and coins. Whilst politics, trade and religion are well-studied, there has been little examination of ancient society in the Tarim Basin because the sources are viewed as limited. GENDISC will challenge this assumption by addressing social issues raised as legal disputes in the Niya Documents, including infanticide, adoption, witchcraft allegations, slavery, murder and marriage transactions. It will identify gender roles (O1), the types of legal cases (O2) and the wider context of issues (O3), and will take a statistical and etymological approach (WP1), study religious texts (WP2) and examine other Tarim Basin documents (WP3) to establish if the documents are indicative of gender biases and discrimination. GENDISC is interdisciplinary, incorporating studies of language, religion, gender, society and law within the broader field of archaeology and Asian studies. It is trans-regional in scope and w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structure and function of γ-secretase studied by single particle cryo-electron microscopy' (2007-2013).

assistant: **Concept**

The γ-secretase intramembrane protease complex plays a critical role in multiple cellular processes including Notch signaling and secretion of amyloid β peptides, the accumulation of which causes Alzheimer’s disease (AD). The enzymatic activity of γ-secretase is, therefore, a prime target for intervention in AD and is of major interest. Yet, despite the detailed knowledge of γ-secretase's function in various cellular processes and disease, structural information regarding the complex is extremely limited and its mechanism of action at the molecular level remains poorly understood. We propose to address this challenge by structurally analyzing γ-secretase and its unique mechanism using single particle cryo-electron microscopy (cryo-EM) as a primary tool. While structural approaches, such as X-ray crystallography, struggle in the study of membrane-embedded complexes in general and in the study of γ-secretase in particular, an initial structure has already been produced using single particle cryo-EM, demonstrating the feasibility of the procedure and its great potential.The host laboratory of Prof. Bart De Strooper is well established in the γ-secretase field, while the applicant, Dr. Nadav Elad, is highly experienced in single particle cryo-EM. Combining our expertise, research will aim at achieving a high-resolution structure in close-to-native conditions, determining subunit arrangement and characterizing functional states of γ-secretase. The proposed project both addresses fundamental biological questions regarding intramembrane proteolysis and has immediate therapeutic implications for AD. Additionally, the project will serve as a platform for future studies of γ-secretase, since numerous unanswered questions regarding its variable composition, interactions with multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Improved Nuclear SIte characterization for waste minimization in DD operations under constrained EnviRonment' (INSIDER) targeting Horizon 2020.

assistant: **Abstract**

Decommissioning and dismantling (D&D) operations are strongly dependent on the facilities history and the inventory of present radionuclides. The D&D processes are significant source of radioactive waste and their management is a major challenge from technical, economical, financial and societal point of view. This is recognized in a number of reference documents and studies on EU and international level. These challenges are naturally subject for further optimisation and the ambition of INSIDER project is to contribute to it as follows. For constrained environments new methodologies are necessary for more accurate initial estimation of contaminated materials, resulting waste volumes and timely planning. This will be based on advanced statistical processing and modelling, coupled with adapted and innovative analytical and measurement methods, with respect to sustainability and economic objectives. The envisaged project outcomes will enable building of a fit-for-purpose representation of the radiological status of facilities (or components), at a relevant precision level allowing making decisions concerning different D&D scenario options. The overall project methodology is based on common case studies in the form of interlaboratory comparisons on matrix representative reference samples and benchmarking. Industrial partners (selected D&D actors) in close cooperation with major EU R&D organisations will drive comprehensive and realistic conclusions formalised in guidelines, recommendations and elements for pre-standardisation initiatives. These will be validated at different scientific and industrial levels and widely disseminated to the broad D&D community and beyond.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EcoWizard: innovative nanomaterials require ecologically based safety assessment' (ECOWIZARD), addressing dissemination and exploitation.

assistant: **Impact**

Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs; and no simple correlation between toxic responses and mass, nanoparticle size or any other particle characteristic is found. Effects often occur only after long-term exposure, whereas evidence of acute toxicity induced by ENMs is limited. Hence, current hazard assessment lacks accurate approaches to assess the safety of ENMs at species level nor does it accounted knowledge for knowledge on how ENMs affect species relationships. To overcome these problems, I address within my proposal 2 key gaps: 1) The current lack of understanding of the chronic effects of ENMs at environmentally relevant conditions at the individual species level as well as at higher ecological levels including considerations of species interactions. 2) The current lack of transferability of dose and response knowledge allowing to extrapolation towards untested (advanced) ENMs and untested species. The EcoWizard project aims to acquire fundamental and generalizable insights into the chronic effects on species and species interactions induced by long-term exposure to (advanced) ENMs at environmentally relevant conditions. My ambitious aim is to combine lab-based experiments and field-realistic mesocosm experiments in tandem with ecophysiological modelling and ecological modelling. Results obtained during this project will ultimately break new grounds by providing the first fundamental insights into the chronic impacts of ENMs on organisms and species interactions, explicitly accounting for the ‘ecology’ in ecotoxicology. The project results wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring the dark matter of the human brain transcriptome: The origin and function of long non-coding RNAs' to be submitted under Seventh Framework.

assistant: **Abstract**

Genome-wide transcription maps of different model species [1-5] reveal an unforeseen number of transcribed DNA segments lacking protein-coding potential [1, 2, 4, 5]. These non-protein-coding RNAs (ncRNAs) are frequently expressed in the brain [6] and, although generally acknowledged as functionally relevant, the biological role of most long ncRNAs remains unclear mainly due to the lack of prediction tools and testable hypotheses. Recent work in the host institution indicates that some brain-expressed ncRNAs regulate the transcription of adjacent protein-coding genes thus providing a criterion to target long ncRNA for further characterization (Ponjavic, J. et al submitted). We propose to compile and analyze a catalog of human long ncRNAs and use it to understand when and how these transcripts emerged during evolution. Using a combination of in silico and in vitro experiments we will identify and functionally characterize long ncRNAs in the human genome, and test the recent hypothesis that some of these transcripts are involved in the transcriptional regulation of their adjacent protein-coding genes. We will particularly focus on transcripts that are specific to primates, as these are more likely to contribute to recently emerged features of the human brain including their relative increase in brain size and complexity. The proposed identification and functional characterization of young brain-expressed ncRNAs is timely and combines the applicant’s expertises in protein-coding gene evolution and the computational and ncRNA competences available in the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Leveraging Anaerobic Digestion through environmental stresses' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Effective (organic) waste management and renewable energy supply are essential in our present society, such as meeting targets of the European Green Deal and the Renewable Energy Directive. Anaerobic digestion can tackle both challenges simultaneously, and has been commonly applied for renewable energy recovery in the form of biogas from organic waste. The complex and sensitive microbial interactions to environmental stressors can cause the failure of anaerobic digestion, imposing challenges for innovation. In LeAD, we introduce the microbial niche nexus concept (tuning microbial communities and their metabolic pathways to achieve multidimensional microbial networks) to achieve more resistant/resilient anaerobic digestion systems, thus improving resource recovery from waste sources under stressed conditions. Hence, LeAD aims to train the next generation environmental biotechnologists in order to address key knowledge gaps and develop models and technologies in anaerobic digestion responding to stressed environmental conditions, which will revolutionize resource recovery from waste towards circular bioeconomy and sustainable development. The 14 tailored projects are tailored based on the design-build-test-learn cycle to train the doctoral candidates with systems knowledge to deal with challenges for transiting waste removal towards resource recovery through anaerobic digestion. To train the 14 doctoral candidates via an international, intersectoral, and interdisciplinary program, LeAD brings together experts from several disciplines, forming a consortium of eight beneficiaries and five associated partners (including three industries). Through both local and network-wide activities and events, LeAD will educate next-generation talents with competitive transversal skills a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neural mechanisms of learning in the infant brain : from Statistics to Rules and Symbols' (Babylearn), addressing dissemination and exploitation.

assistant: **Impact**

Infant is the most powerful learner: He learns in a few months to master language, complex social interactions, etc. Powerful statistical algorithms, simultaneously acting at the different levels of functional hierarchies have been proposed to explain learning. I propose here that two other elements are crucial. The first is the particular human cerebral architecture that constrains statistical computations. The second is the human’s ability to access a rich symbolic system. I have planned 6 work packages using the complementary information offered by non-invasive brain-imaging techniques (EEG, MRI and optical topography) to understand the neural bases of infant statistical computations and symbolic competence from 6 months of gestation up until the end of the first year of life.WP1 studies from which preterm age, statistical inferences can be demonstrated using hierarchical auditory oddball paradigms.WP2 investigates the consequences of a different pre-term environment (in-utero versus ex-utero) on the early statistical computations in the visual and auditory domains and their consequences on the ongoing brain activity along the first year of life.WP3 explores the neural bases of how infants infer word meaning and word category, and in particular the role of the left perisylvian areas and of their particular connectivity.WP4 questions infant symbolic competency. I propose several criteria (generalization, bidirectionality, use of algebraic rules and of logical operations) tested in successive experiments to clarify infant symbolic abilities during the first semester of life.WP5-6 are transversal to WP1-4: WP5 uses MRI to obtain accurate functional localization and maturational markers correlated with functional results. In WP6, we develop new tools to combine and analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Measurement of the mass of the w boson and study of ist couplings' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and contents The project is to measure the mass of the W boson, the charged mediator of the weak force, and to study its couplings. The project will be carried out within the ALEPH collaboration, one of the four LEP experiments at CERN. This large collaboration consists of 380 physicists from 33 institutions. The LEP accelerator has been upgraded to exceed the W pair production threshold, and provide high luminosity at these energies starting in 1997. The candidate will participate to the data taking. The data statistics which will be accumulated in the 2 or 3 following years should increase more than ten-fold the present one. This will permit to measure the W mass to a precision of 25 MeV/C2 enabling for the first time to check the consistency of the standard model of particle physics at the quantum level. This research is complementary to the direct search for the Higgs boson, responsible for the mass of particles, because it will determine, via the electroweak radiactive corrections, a mass window of 30% for the Higgs boson. Trainig content (objective, benefit and expected impact) The candidate will participate to data taking. He will have to develop sophisticated data analysis methods to reach the accuracy of 2 parts in 100000 needed. This will imply not only to master statistical data analysis and the detailed methods to estimate the systematc effects, but also become an expert in the phenomenonology of electroweak interactions. Links with industry/industrial relevance (22) The Saclay laboratory is embedded in a large research plant, and builds major parts of the future LHC experiments. This environment with engineers and their industrial partners is ideal for an introduction to the world of industry when coming from pure research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Harnessing Hematopoietic Stem Cell Breakthroughs to Pioneer Advances in Transplantation Therapies' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Hematopoietic stem cell transplantation (HSCT) is a groundbreaking therapy that has transformed the treatment of severe hematological and immune disorders. It involves infusing healthy or corrected hematopoietic stem cells (HSCs) into a patient to restore their blood cell production. Despite its remarkable success, HSCT is currently limited to the most severe cases due to several key challenges. These bottlenecks include inefficient HSC mobilization, limited engraftment leading to insufficient clonal diversity, and the toxicity of chemotherapy-based conditioning regimens.This comprehensive proposal outlines a transformative approach to address these limitations head-on, enhancing both the efficacy and safety of HSCT. The project aims to:1.Uncover the key factors governing HSC engraftment and egress: Using optimized genome-wide gain- and loss-of-function in vivo screening in HSCs, I will identify the pivotal players responsible for HSC engraftment and egress. These insights will inform the development of innovative mobilization strategies and the engineering of HSCs to confer a transient engraftment advantage.2.Establish a mobilization-based conditioning regimen: I will exploit the temporary niche depletion induced by mobilizers to optimize a genotoxic-free regimen. By harnessing cell surface profiling data and potentially using mobilizer-resistant variants generated through directed evolution, I will tilt the competitive balance between freshly mobilized and infused HSCs, favoring the engraftment of infused cells.This project seeks to pioneer avant-garde methods that enhance mobilization and engraftment while avoiding the use of toxic conditioning regimens, thereby addressing major HSCT limitations. These advancements hold the potential to transform HSCT into a safer, m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Shaping the ethical dimensions of smart information systems (SIS)  – a European perspective' (SIS).

assistant: **Concept**

In collaboration with a broad range of stakeholders, the SHERPA project will investigate, analyse and synthesise our understanding of the ways in which smart information systems (SIS; the combination of artificial intelligence and big data analytics) impact ethics and human rights issues. It will develop novel ways of understanding and addressing SIS challenges, evaluate with stakeholders, and advocate the most desirable and sustainable solutions. SHERPA will: (1) represent and visualise the ethical and human rights challenges of SIS through case studies, scenarios and artistic representations, (2) work with a range of stakeholders to identify their concerns and preferred solutions (via interviews, a large-scale online survey, a Delphi study, a stakeholder board), (3) develop and publish a workbook on responsible development of SIS, (4) present technical and regulatory options (e.g., terms of reference for a regulator), (5) validate and prioritise the proposals through multi-stakeholder focus groups, and (6) advocate, promote and implement the most promising solutions through targeted dissemination and communication activities. The SHERPA consortium has 11 partners from six European countries (representing academia, industry, civil society, standards bodies, ethics committees, art).


**Keywords:** artificial intelligence, privacy, human rights, big data analytics