RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Euro Summer School: Dynamics of Molecular Collisions Relevant to the Evolution of Interstellar Matter' in the context of a Fifth Framework call.

assistant: **Objectives**

For understanding the evolution of complex chemical or physical systems a detailed knowledge of the fundamental interaction of the matter at an atomic or molecular level is required. Typical examples include technically important processes such as combustion, fusion plasmas or discharges. A more remote" objects of practical and scientific interest is the atmosphere of our earth. In this summer school we want to apply the knowledge on collision dynamics to fascinating objects which are "far away": it is intended to bring together theoreticians and experimentalists, physicists, chemists, and astronomers, observers and modellers in order to discuss the formation and desintegration of molecular structures under the extreme conditions prevailing in dense or diffuse interstellar clouds, star forming regions, circumstellar discs or other interesting regions in our universe.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00020-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Indentification and optimisation of novel anti-infective agents using multiple hit-identification strategies'.

assistant: **Objectives**

Given the rapid emergence of anti-infective resistance, drugs with a novel mode of action are urgently needed. Because of an exhaustion of existing strategies, a low return on investment and the fact that anti-infectives are difficult to develop (e.g., crossing the peculiar cell wall of Mycobacterium tuberculosis), promising un(der)explored targets and unconventional hit-identification strategies are needed.I have selected three anti-infective targets based on their biochemical context for which few or no small-molecule inhibitors are known:1) The antimalarial and antituberculotic drug target DXS is part of a unique biosynthetic pathway for pathogens that is absent in humans, thereby circumventing selectivity issues. Both diseases are a serious health threat with around 1.9 million deaths per year. 2) Energy-coupling factor transporters are essential vitamin importers for pathogens such as Staphylococcus aureus, the causative agent of methicillin-resistant Staphylococcus aureus (MRSA) infections.3) The DNA polymerase sliding clamp DnaN has polymerase and DNA repair activities and is an excellent drug target for the development of antibacterial agents against Gram-negative and –positive bacteria given the low incidence of resistance development.I will address these targets, employing a unique combination of potentially synergistic hit-identification strategies that take into account protein flexibility, provide access to novel scaffolds and give me a cutting edge for the development of novel anti-infectives. This ERC proposal builds on my experience with the first two targets and provides an excellent platform for the new target DnaN. My expertise in synthetic organic and medicinal chemistry and established hit-identification strategies together with my collaborations wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of indicators & econometric analysis on R&I performance' in the context of a Horizon Europe call.

assistant: **Objectives**

This project continues the research activity carried out by the JRC in support of the work on better evidence for policy-making by the Directorate-General for Research & Innovation (R&I). It focuses on three interrelated research streams. The first research line consists in the development, refinement and update of the methodologies concerning composite indicators and dashboards measuring R&I performance of EU Member States (MSs) and selected benchmark countries, more specifically, the Innovation Output Indicator (IOI) and the People, Planet and Prosperity (3P) dashboards. The second research line concerns the green and digital technologies in the EU and the knowledge base needed for their development, and includes a description of recent technological trajectories and an analysis of the role of innovative foreign direct investments flows to the establishment of the related knowledge base. The third research line is about the complex relationships between digital technologies on the one side and the social, economic and environmental domains of sustainable development on the other one. Using the lens of scientific knowledge through scientific publications, the research entails first the benchmarking of EU MSs performance in the production of pertinent scientific knowledge, and second the assessment of the contribution of advanced digital technologies to the achievement of Societal Development Goals.


**Keywords:** research and innovation, indicators, composite indicators, green transition, technological development, Sustainable Development Goals, internationalization of R&D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Community and Ramp Aircraft NoisE', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Reducing aircraft noise emission is a priority for the European aviation sector, since both community and occupancy noises have significant environmental impact and constrain airport activities. In addition there is a strong interplay between low-noise technologies, fuel efficiency and air pollution.Computer simulations play a crucial role in the acoustic design of aircraft airframes and engines, by selecting novel concepts, optimizing final designs, and avoiding costly flight and static tests. But current computational tools are either unable or too inefficient to perform large acoustic simulations over the complete frequency range and taking into account the full geometrical and physical complexity.Further improvements in computational aero-acoustics will require novel numerical schemes, better integration with other engineering design tools, and also stronger alignment with the needs of private sector end-users. To achieve this, LMS and ISVR are leading this training and research program, together with Rolls-Royce as associated partner. The research activities will cover high-order methods, novel techniques for accurate geometry description, and extensions of the Boundary Element methods. These techniques will be used for the acoustic design of nacelles and Auxiliary Power Units (APU) which feature complex geometries and flow configurations, and for predicting installation effects (acoustic interaction between the engine and the wing) which currently requires vast computational resources.This research program is supported by a range of courses that combines the complementary expertise of the project partners (aero-acoustics, computational methods, CAD methods, aircraft noise). Such a combination of multi-disciplinary training activities is currently not available els
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Effects of folic acid and its active metabolite 5-methyl-tetrahydrofolic acid on endothelial function, superoxide production and gene expression in human atherosclerosis'.

assistant: **Objectives**

Endothelial dysfunction is believed to be a major step in atherogenesis. Decreased nitric oxide (NO) bioavailability in human vessels may be the result of both increased oxidative deactivation or decreased production by endothelial nitric oxide synthase (e NOS) in human endothelium.Furthermore, deficiency of tetrahydrobiopterin (BH4), a cofactor for eNOS, leads to eNOS uncoupling, making vascular endothelium a source of superoxide anions. Evidence suggests that folic acid may improve endothelial function, but the underlying mechanisms of this effect remain obscure. In the present study we aim to investigate the effects of folic acid on human vessels.The population of the study will be consisted of 120 patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) operation. Twenty patients will be treated for 6 weeks before their CABG with folic acid 5mg/day, 20 with folic acid 400g day and 20 with placebo, while 60 patients will participate in the in vitro part of the study. The experiments will be contacted in human saphenous veins, radial arteries and internal mammary arteries derived from these patients during grafts harvesting.Particularly, we will examine the effect of chronic treatment with folic acid on endothelial function, superoxide production and multiple gene expression (using micro arrays technology) in human vessels. Furthermore we will examine the acute effect of 5methyltetrahydrofolic acid (5MTHF), the active form of folic acid, on endothelial function, superoxide production and BH4 levels in human vessels in vitro.Additionally, we will examine the ability of 5MTHF to scavenge superoxide directly, as well as its effect on BH4 levels in endothelial cells cultures. Finally we will investigate the ability of circulating markers of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nuclear envelope attachment and dynamics of Human telomeres - unravelling nuclear organization'.

assistant: **Objectives**

The spatial and temporal organization of the nucleus and its components are essential for genome regulation. During interphase of mammalian cells the nuclear envelope maintains the shape and the mechanical integrity of the nucleus, but also provides an anchor for chromatin that is connected to its inner side. This interaction mediates the regulation of gene expression, DNA replication and the maintenance of genome stability. In human cells I found that a large subset of telomeres, the natural ends of linear chromosomes, are transiently anchored to the nuclear envelope specifically during postmitotic nuclear assembly. Chromatin organization undergoes extensive changes during progression through the cell cycle, particularly during mitosis with the nuclear envelope breakdown and the compaction of chromatin into metaphase chromosomes. The interaction between chromosome ends and the nuclear envelope at the stage where the nucleus is reforming post-mitosis suggests a new role for telomeres in nuclear organization. My aims are 1) to screen for interacting partners that mediate the cell-cycle dependent telomere tethering to the nuclear membrane; 2) to unravel the molecular mechanism of telomere-nuclear envelope association over the cell cycle by combining biochemistry and state-of-the-art microscopy; 3) to map the subset of chromosomes which ends are tethered using subtelomere specific FISH probes and determine whether they are conserved throughout cell divisions and if it plays a role in organizing chromosome territories; 4) to examine telomere dynamics in cells from premature aging syndromes affecting the nuclear envelope integrity using live imaging confocal microscopy, and understand the connection between telomeres, nuclear envelope, and aging. The originality of my scient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GSK-3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment.' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Neuronal circuits in mammalian brain act predominantly via excitatory synapses on dendritic spines. Formation of new spines in adult brain constitutes the structural basis of neuronal plasticity. The underlying molecular mechanisms remain largely unknown but depend essentially on kinase-dependent signalling pathways. Final formation of synapses on spines depends on dynamic interactions of microtubuli and actin-filaments that are also controlled by kinases. Deterioration of these processes to different extents are thought to cause the cognitive decline in normal ageing as well in Alzheimer's disease (AD) and familial fronto-temporal dementia (FTD). Protein tau is a microtubule associated protein and GSK-3 kinases are proposed as the major tau-kinases in vivo. Their exact contributions remain to be functionally defined in vivo both in normal neuronal plasticity and in degeneration. We develop pre-clinical models for AD and FTD that have tauopathy in common as essential pathogenic component and will explore the GSK-3 kinases in vivo by manipulating their activity genetically, pharmacologically and biochemically. Inhibitors are wanted that are effective and specific and enter brain in vivo. This proposal engages in three activities: (i) elucidate physiological functions of GSK-3 kinases in synaptic plasticity in adult and ageing brain, and in degenerating brain; define fundamental neuron-specific functions of GSK-3 kinases in vivo in novel mouse models; define contributions of GSK-3 kinases to amyloid and to tau pathology, separately and combined in vivo in validated mouse models (ii) design novel inhibitors of GSK-3 kinases and alternative tools to inhibit GSK-3 activity in vivo (iii) test pharmacological and peptidometic inhibitors of GSK-3 in validated mouse models of ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mapping vast functional landscapes with single-species resolution: a new approach for precision engineering of microbial consortia' (ECOPROSPECTOR) targeting Horizon Europe.

assistant: **Abstract**

Given a list of candidate species, which community should one form to optimize a target function? Answering this fundamental ecological question is particularly urgent in the emerging field of synthetic microbial ecology, where it would dramatically improve our ability to design multi-species consortia for biotechnological applications. An empirical solution is out of reach, due to the astronomical number of possibilities: one could form ~1E30 possible assemblages from just 100 species. To provide a solution, ECOPROSPECTOR will borrow state-of-the-art ideas from Evolutionary Systems Biology and the theory of Fitness Landscapes, where similarly vast combinatorial spaces must be explored to find optimal sequences (peaks) in a genotype-phenotype map. This will result in a new and groundbreaking theoretical paradigm to map community composition and function in large communities at the single-species level. My proposal is motivated by exciting preliminary results revealing an ecological parallel to the emerging evolutionary concept of global epistasis: the functional effect of adding a species to a community can be predicted by a simple mathematical relationship. I will start by characterizing these relationships in a model empirical system consisting of 100 starch-degrading soil bacteria. I will then use machine learning to reconstruct and navigate the full combinatorial landscape between community composition and function, in search of communities that optimize the rate of starch hydrolysis. Through genetic and environmental manipulations and mathematical modeling, I will then mechanistically explain the emergence of those predictive equations and causally link them with species traits. Besides solving a problem of critical practical importance, the theoretical paradigm em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Eco-Compatibility of industrial processes for the production of primary goods' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The main objectives are as follows:* The overall objective of the project is to define the development policies of countries on the way of industrialization. Both standardized and innovative methodologies will be utilised for the evaluation of the environmental impact of industrial processes for the production of primary goods.* In the case of China, the main objective will be the formulation of a sustainable energy development and of a management strategy enabling an alleviation of the environmental and ecological problems associated with the coal-based power generation for urban and industrial use through cleaner processing technology, improved pollution abatement and advanced waste recycling and reuse technologies.* The final object of the research is to induce the development of innovative models which take into account energy sources, the reduction of the environmental impact and the production techniques which are suitable to optimize the recycling operations.Expected Outcome* Development of a concept of disassembly factories in China. A possible layout and material flow for a factory in China will be planned. While performing this step the energy management will be kept in mind in order to reduce of at minimum 10% the energy input in the studied factory.* Definition of a suitable production methodology in relation to the technical and normative data. On the basis of a deep knowledge of the processes, the environmental simulation and the optimization of the whole life cycle will be performed for some mechanical industry products.The key activities envisaged are:* Creation of a data-base regarding the Chinese situation.* Development of more environment friendly efficient products concerning recycling and disassembly processes.* Definition of the differences in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sea harvesting in the transition from hunter-gatherer to farmer societies. Archeological microscopic and molecular approaches to shell midden stratigraphy' to be submitted under Horizon 2020.

assistant: **Abstract**

While marine resources played a crucial role in Mesolithic societies, the role of coastal adaptations associated with the first Neolithic farmers is still poorly known. The present project aims to investigate Mesolithic and Neolithic shell midden formation using sedimentary microscopic signatures on anthropic deposits from Atlantic Iberia. SEArch will apply state-of-the-art developments on lipid biomarkers and stable isotopes analysis of organic molecular data stored in archaeological sediments. The main objective is to understand behavioural and environmental changes associated with the exploitation of aquatic resources. SEArch will achieve this goal with a three-fold approach: (1) by reconstructing formation processes at key shell midden sites; (2) by identifying (macroscopically invisible) fish and shellfish to infer foraging locals and processing strategies, and (3) by inferring temporality of foraging behaviour using C and N stable isotopes. The project will create experimental datasets on thermal alteration of bioclasts and construct a novel marine biomarker database for archaeologists. The SEArch project seeks to contribute to the debate on the Neolithization process of western Europe by taking a contextualized approach to the study of coastal adaptations and their role as possible resilient behaviours during the Neolithization process.


**Keywords:** Geoarchaeology, Prehistoric coastal adaptations, Archaeological micromorphology, Archaeological biomarkers, Stable isotopes, Mesolithic, Neolithic, Shell middens