RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel enhancer deletion strategy to determine non-classical monocyte function in atherosclerosis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cardiovascular disease (CVD) is the main cause of death worldwide, and accounts for 40% of deaths within the EU. Monocytes are immune cells that are directly implicated in atherosclerosis, the leading cause of CVD. In both mouse and human there are two principle monocyte subsets, termed 'classical' and 'non-classical'. The classical monocyte subset is a key driver of atherosclerosis, whereas evidence suggests that the non-classical monocyte subset plays a protective role in disease. However, directly testing the role of non-classical (Ly6Clow) monocytes in disease has not been possible due to a lack of experimental models. In preliminary research Dr. Thomas used a novel multidisciplinary approach to generate mice that selectively lack Ly6Clow monocytes. This work identified a small region of the genome, termed an enhancer, that controls expression of the key transcription factor Nr4a1 in Ly6Clow monocytes. Deleting this enhancer produced a mouse that lacks Ly6Clow monocytes but is otherwise normal, unlike existing methods for Nr4a1 deletion. MONOCLE will exploit this novel mouse model to test the role of Ly6Clow monocytes in atherosclerosis, and to gain new insight into mechanisms regulating non-classical monocyte development. Thus, MONOCLE has the potential to reveal new molecular and cellular therapeutic targets in the battle against CVD. MONOCLE will also provide Dr. Thomas with new skills in in vivo CVD research, financial-management and project planning, forming the foundation for his role as a successful independent research group leader in Europe. The fellow will bring to the host institute a unique skill set enabling functional genomic and epigenetic analysis of in vivo cell populations, and access to a network of world-class researchers in epigenetics and monoc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Colonial Legacies of Universities: Materialities and New Collaborations'.

assistant: **Innovation**

Historically, universities have been foundational to promoting and shaping European culture, knowledge, and values including democracy, human dignity, freedom, human rights, and equality as a global project. They have also been leading institutions for promoting dialogue and building strategic alliances between the global north and the global south in the fields of science, heritage, and cultural and creative industries.In recent years, universities and museums in Europe have increasingly developed innovative approaches to address the colonial entanglements in their collecting practices, material legacies, understandings of national and transnational identities, and the production of knowledge.However, unfinished conversations with former colonies about colonial legacies in and beyond Europe remain barriers to cooperation and exchange as well as the promotion of European values. COLUMN brings together partners from the creative industries, seven European universities from the Coimbra network, including some of the oldest research universities in Europe, and partner universities from the global south to rethink, reframe, and refresh approaches to European and postcolonial arts, culture, heritage, and societal values.Focusing on four pilot interventions that apply new collaborative and decolonial curatorial practices, COLUMN will lead the development of policies, recommendations, and good practices for new collaborations around European university heritage through strategic partnerships within and beyond the borders of the EU. Bridging knowledge production and creative arts practices, it builds an understanding of European cultural heritage as a vehicle to strengthen rights-based and equitable approaches to colonialism in dialogue with global south partners - thus paving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Artificial General Intelligence software enabling workforce relief for optimised results and increased efficiency' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Xepholution is a cutting edge technology based on Artificial General Intelligence. Contrary to the so called ‘narrow’ Artificial Intelligence (or ‘weak AI), Xephor’s technology is able to develop creativity and perform intellectual tasks typical to humans. This advance technology, is the first one worldwide which is able to program itself in C++ and learn tasks from experience autonomously. The Cloud software observes and learns from a humans working on the computer in which an user-account is logged in, learns what they are doing, and analyses how to react appropriately. The learning process takes place in five stages: a) observation b) confirmation c) simulation d) cooperation e) autonomy. The process takes approximately 4 to 6 months for the system to be ready to take over the tasks completely and progress to creating new solutions and producing new ideas.  The founding of Xephor was to directly propagate the cutting-edge AI technology of Xepholution. Xepholution’s creation was highly steeped in scientific and mathematical research, as well as market research indicating the gap with today’s solutions in addressing intelligent usage of software from an artificial source. Xephor have brought to fore a technology finally able to address the effectiveness concerns surrounding current AI being able fill the shoes of an employee; specifically when using speciality software.The proposed work in Phase 1 of the SME instrument fits into Xephor’s plan to bring Xepholution onto the market by contributing the financial resources needed to plan a fast and efficient wider deployment of the product across its target initial market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SYmbiosis for eNERGY harversting concepts for smart platforms on foils' (SYNERGY) under Horizon 2020.

assistant: **Objectives**

SYNERGY addresses the call TWINN-2018 (H2020-WIDESPREAD-2018-2020), aiming to strengthen the scientific and technical competences at the Portuguese institutions in the field of energy harvesting and micropower management as a key component towards self-sustainable smart platforms on flexible substrates. Therefore, proper training and expertise transfer in the field of energy harvesting and management is mandatory to complement and consolidate past activities at the widening institutions on low temperature, flexible and paper electronics. Driven by the quest for excellence, the Portuguese University and Research Institutions are so proposing to be linked with outstanding European institutions in the field of printed electronics, solar cells and batteries on foils (VTT); battery and supercapacitors developers (POLITO); energy integration and power management (Tyndall); and materials, devices and systems analysis, validation and modelling (FhG-IKTS). These institutions, with such valuable profiles will allow to complete the value chain for the scientific strategy of the Portuguese widening institutions.This will stimulate scientific excellence and innovation capacity that will boost the development of new smart self-powered smartplatforms fully aligned with Portuguese national and regional research and innovation strategies, as it is the case of the recentlyestablished collaborative laboratory AlmaScience related to “Paper Electronics”. Moreover, the project’s impact towards society andstakeholders, will be conducted by SPI, which has a strong experience in this area, supported by the European Academy of Science, an excellent vehicle to bring academics together around the relevance of energy as crosscutting element for the strategy of the future of our society.


**Keyword
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeting endothelial metabolism: a novel anti-angiogenic therapy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Current anti-angiogenesis based anti-tumor therapy relies on starving tumors by blocking their vascular supply via inhibition of growth factors. However, limitations such as resistance and toxicity, mandate conceptually distinct approaches. We will explore an entirely novel and long-overlooked strategy to discover additional anti-angiogenic candidates, based on the following innovative concept: ¿rather than STARVING TUMORS BY BLOCKING THEIR VASCULAR SUPPLY, we intend TO STARVE BLOOD VESSELS BY BLOCKING THEIR METABOLIC ENERGY SUPPLY¿, so that new vessels cannot form and nourish the growing tumor. This project is a completely new research avenue in our group, but we expect that it will offer refreshing long-term research and translational opportunities for the field.Because so little is known on endothelial cell (EC) metabolism, we will (i) via a multi-disciplinary systems-biology approach of transcriptomics, proteomics, computational network modeling, metabolomics and flux-omics, draw an endothelio-metabolic map in angiogenesis. This will allow us to identify metabolic regulators of angiogenesis, which will be further validated and characterized in (ii) loss and gain-of-function studies in various angiogenesis models in vitro and (iii) in vivo in zebrafish (knockdown; zinc finger nuclease mediated knockout), providing prescreen data to select the most promising candidates. (iv) EC-specific down-regulation (miR RNAi) or knockout studies of selected candidates in mice will confirm their relevance for angiogenic phenotypes in a preclinical model; and ultimately (v) a translational study evaluating EC metabolism-targeted anti-angiogenic strategies (pharmacological inhibitors, antibodies, small molecular compounds) will be performed in tumor models in the mouse.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The development of flexible large screen video and data displays for use in daylight applications beepak B.V.' (1994-1998).

assistant: **Innovation**

The three main video-wall television systems inhabit a number of set-backs such as: high price, immobility and heavy weight, high energy consumption, poor picture quality (quality distortion such as aberrations and colour distortion) and low brilliance. The proposed flexible video-wall combines a software controlled digital micro mirror device (DMD) with a flexible light transportation for colour or black and white high brilliance live data" and other "images" picture or data generation. A wide range of two dimensional weather resistant arrays for daylight applications will come available. The proposed large screen flexible video-wall will have a standard size of 256*1.92 m. Several displays can -be coupled without any loss of picture quality."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hidden metastable mesoscopic states  in quantum materials' (HIMMS) under Horizon Europe.

assistant: **Objectives**

Non-equilibrium states of matter have become of great fundamental and practical interest in recent years because of their wide importance in diverse areas of physics. With the rapid development of new time-resolved techniques, the temporal dynamics of competing processes and interactions were recently elucidated in a wide variety of complex condensed matter systems. However, the physics of metastable mesoscopically non-periodic quantum textures emerging from phase transitions has been largely experimentally inaccessible till now: current state of the art time-resolved methods using x-rays, electron diffraction, photoemission, THz and optical spectroscopy all average over multiple transition outcomes. Moreover, they cannot resolve irregular nonperiodic nanoscale structures. Thus, a large field of mesoscopic quantum physics of metastable quantum states remains largely unexplored. Here we propose to develop a unique set of tools to investigate mesoscopic metastable irregular textures created under controlled non-equilibrium conditions in quantum materials, with focus on topological transitions and quantum jamming phenomena. Temporally tempered excitation techniques combined with time-resolved scanning tunnelling microscopy will be used to studying single and multiple transition outcomes with atomic spatial resolution on timescales from picoseconds to hours. Experiments supplemented by new theoretical approaches will address the creation processes, relaxation dynamics and quantum decoherence of metastable mesoscopic structures, as well as manipulation and control. Theoretical approaches for addressing resulting quantum states include fracton-derived models and quantum annealing on a quantum computer. The project opens the path to detailed exploration of a new class of physi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovation Residues – Modes and infrastructures of caring for our longue-durée environmental futures' to be submitted under Horizon Europe.

assistant: **Abstract**

Innovation residues designate those left-behinds of innovations that profoundly shape human lives as they stay with us for a long timewell beyond moments of production and consumption, and well beyond the time horizons considered when assessing the worth of innovations. Residues are material witnesses to culture and practice of innovation, to diverse politics at work, and to the limited attention to long-term sustainable futures in a world predominantly shaped by short-term impact thinking. Today, as technological innovations are seen as foundational to the future development of contemporary societies, the entanglements of innovation and society require closer scrutiny more than ever. INNORES offers a novel, empirically and theoretically rich approach to do so through a radically switched perspective. It does not put innovations themselves centre-stage, assigning to residues the role of potentially disruptive side-effects, but takes residues as the lens to study democratic innovation societies. It investigates how societies conceptualise, make sense of, live with, and care for innovation residues, and how this shapes their relations to innovation. Studying innovation societies through the complex networks and manifestations of residues, INNORES opens up new perspectives on how local choices and global impacts relate, on intergenerational justice and responsibility, on whose future imaginaries, values, and knowledges count when making choices, on how benefits and risks are distributed, and on modes and infrastructures of care for environmental futures. INNORES engages with three very different kinds of residuesnuclear waste, microplastics and data waste. Using a specifically tailored qualitative, comparative mixed-method approach, it investigates them in different arenas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Safe-Guarding Home  IoT  Environments with Personalised  Real-time Risk Control'.

assistant: **Concept**

To effectively respond to the multitude & complexity of cybersecurity challenges in smart-homes GHOST deploys a pioneering software-enabled ‘usable security’ solution. The project brings professional level security to the European citizens and to this end it: (a) increases the automation level & effectiveness of existing security services; (b) opens up the cybersecurity ‘blackbox’ to consumers, creates understanding and builds trust through effortless decision support & advanced ‘usable transparency’; (c) enhances the system’s self-defence by safeguarding critical security-related data using blockchain technology. GHOST software will be embedded in an adequately adapted smart-home network gateway though it will be designed to be vendor-independent. A dedicated middleware layer ensures interoperability with multiple gateways & IoT devices. GHOST considers the relationship between security and usability to be an integration challenge (positive sum game) and definitely not a trade-off (zero-sum game). In this context, the project envisions to lead a paradigm shift in consumer cybersecurity by successfully coupling usable security with transparency and behavioural engineering. The envisaged user experience will systematically trigger security-friendly behaviour aiming at establishing appropriate ‘habitual behaviours’. The solution will perform network analysis & deep packet inspection for suspicious pattern recognition, will apply machine learning for malicious behaviour detection, will carry out context-aware real-time risk assessment, and widely apply analytics & visualization for effortless user comprehension & decision support. In short, GHOST will (i) increase cybersecurity resilience; (ii) boost usability & automation; and (iii) enhance the competitiveness of European
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dissecting the Contributions  of Neurogenesis-Defined Subpopulations  of Hippocampal Neurons to Balancing Memory Stability and Malleability' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The ability to update memories underpins adaptive behaviours, ensuring that our internal models of the world remain consistent with the dynamic environments we inhabit. Striking a balance between memory stability (the persistence and robustness of memories over time) and malleability (the capacity to update memories in response to new information) is thus essential to learn from experience and adapt to change. While the biological foundations of memory stability are increasingly understood, the mechanisms supporting memory malleability – and how they balance with stability – remain largely unknown. What distinguishes a stable memory from a malleable one? What processes govern the updating of malleable memories, and what prevents updates in stable memories? How is the balance between stability and malleability regulated? To answer these questions, we will leverage our recent discovery that the propensity for stability or malleability of a memory shifts over time in association with activity dynamics in corresponding neurogenesis-defined hippocampal neuron subpopulations. Specifically, we showed that Early-Born Neuron (EBN) activity supports stable memory states and prevents memory updating, while Late-Born Neuron (LBN) activity is associated with malleable states and promotes memory updating. Based on these findings, we hypothesise that a key mechanism regulating the stability/malleability balance lies in the interplay between activity dynamics of hippocampal EBNs and LBNs, with mutual interactions between these subpopulations underpinning memory updating and its flexible use in response to shifting contingencies. Building on this hypothesis, our proposal will use cutting-edge genetic, cellular, network, and behavioural approaches in rodents to dissect mutual interaction