RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanoscale Chromatin Response to Mechanical Stimulus' under Horizon Europe.

assistant: **Concept**

Cells respond to physical stimuli from their environment, drastically changing their chromatin organization. Direct nuclear mechanotransduction affects cell behavior, but this mechanism is still not fully understood. This unsolved link is due to the difficulty of finding tools to generate precise mechanical signals and observe changes in chromatin at the nanoscale level.NanoCHROMS aims to understand the effect of nuclear mechanotransduction on nuclear architecture. We aim to characterize the mechanism driving localized chromatin structure changes in response to direct physical stimuli, and how these changes relate to cellular state. NanoCHROMS will exploit two novel and powerful technologies, Nanofabrication and Single Molecule Localization Microscopy (SMLM). For that, we will use nanopillars as nanomechanical actuators. By culturing somatic, stem and cancer cells in a fabricated nanopillar surface, purposely designed to be SMLM-compatible, we can exert a precise, controlled, and replicable force in the nucleus. Using SMLM, we can unveil higher order chromatin folding with nanometric precision, obtaining positional information of DNA and nucleosome packaging, directly related to cell function. By using SMLM in cells growing on nanopillared surfaces, we can establish the changes of chromatin in direct relation to the physical point of application of the stimulus at the nanoscale. Finally, using sequence-specific imaging approaches (Oligopaints) we will study the nuclear positioning and compaction of genes whose expression is drastically affected by mechanotransduction.NanoCHROMS will contribute to understanding the mechanisms driving expression changes, maintenance of stemness and oncogenesis by mechanostimulus, being a steppingstone in projects working in the interface
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Percolation and conductivity in fluids containing rod-like particles' (Perla).

assistant: **Concept**

The PERLA project aims at developing electrically conductive fluids containing rod-like particles. Their novelty is based on the formation of dynamical system-spanning networks in fluid flow. It is well established that rod-like particles do not simply align, but do tumble and rotate in shear or elongational flow. However, the consequences of this tumbling on the percolation and electrical conductivity of suspensions are still unknown. This behaviour is expected to promote collisions and electrical connectivity throughout the suspension. PERLA will validate this fundamental hypothesis, and provide thereby new concepts for the development of conductive fluids with low viscosity, high and tunable conductivity. Systems of carbon nanotubes and short carbon fibers will be used as conductive Brownian and non-Brownian rods. They will be processed and optimized based on the longstanding expertise of the investigators in carbon chemistry and fiber processing. The structure, rheological and electrical properties of the suspensions will be characterized in depth in various flow conditions, from dilute to concentrated regimes. The latter will be of particular interest with the formation of liquid crystalline phases in which tumbling is also well established. The basic knowledge gained in PERLA will be exploited in examples of applications, including flow capacitors, capacitive water desalination and soft electronic sensors and vibrational energy harvesters. These applications are particularly promising regarding energy and environmental issues. However, they are currently limited by the use of highly viscous slurries made of spherical particles, or of heavy and poorly stable liquid metals. The fluids in PERLA will circumvent these limitations, and provide new degrees of freedom due
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The molecular regulation of T helper cell subtype plasticity.' (THPLAST).

assistant: **Innovation**

Naïve CD4+ T cell differentiate into distinct lineages to achieve successful adaptive immune responses to diverse categories of pathogens. The development of these effector cells is controlled by cytokines, transcription factor interactions and chromatin modifications. In addition, several of the differentiated subtypes can interconvert, a property known as plasticity.  However, the molecular regulation of flexibility of this subset cells is still unresolved. I propose to explore the molecular machinery of the T helper (Th) effector cells’ plasticity, specifically of Th subset 2 plasticity to Th1, as understanding of this reprogramming is a key target of autoimmune- and allergen-specific immunotherapy.I plan to study the regulation of Th2-Th1 cell plasticity both experimentally and computationally. I will identify the gene expression level dynamics as well as the epigenetic events during plasticity using RNA- and ChIP-deep sequencing. These results will be processed by computational tools to define the hierarchy and dynamics of molecular regulators, and to predict key molecular players (transcription factors, microRNAs) responsible for expression of the specific cytokines. I will also monitor specific RNA and protein expression at a single cell level, and identify specific regulatory interactions, including the nucleic acid motifs involved.This research will reveal insights into the balance between lineage commitment and plasticity, which is a key question in developmental biology, and in general will impact a wide range of areas in biology from stem cell biology to cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shaping consumer-inclusive data pathwaYs towards the eNERGy transItion, through a reference Energy data Space implementation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SYNERGIES introduces a reference Energy Data Space Implementation that will attempt to unleash the data-driven innovation and sharing potential across the energy data value chain by leveraging on data and intelligence coming from diverse energy actors (prioritizing on consumers and introducing them as data owners/ providers) and coupled sectors (buildings, mobility) and effectively making them reachable and widely accessible. In turn, it will facilitate the transition from siloed data management approaches to collaborative ones which promote the creation of a data and intelligence ecosystem around energy (and other types of) data and enable the realization of data (intelligence)-driven innovative energy services that (i) value the flexibility capacity of consumers in optimizing energy networks’ operation, maximizing RES integration and self-consumption at different levels of the system (community, building), (ii) evidently support network operators in optimally monitoring, operating, maintaining and planning their assets and coordinating between each other (TSO-DSO collaboration) for enhancing system resilience, (iii) create an inclusive pathway towards the energy transition, through consumer empowerment, awareness and informed involvement in flexibility market transactions, (iv) step on real data streams and intelligence to deliver personalized and automated features to increase prosumer acceptance and remove intrusiveness, (v) facilitate the establishment of sustainable LECs by enhancing their role with Aggregator and BSP functions, and (vi) establish solid grounds for the creation of a new economy around energy data produced and shared across a complex value chain, in a secure, trustful, fair and acceptable manner. SYNERGIES will be extensively validated in 3 large-s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'operAtional seNsing lifE technologies for maRIne ecosystemS' to be submitted under Horizon Europe.

assistant: **Abstract**

In ANERIS, we propose to develop the next generation of scientific instrumentation tools and methods for sensing marine-life. The design of the new instruments and methods will integrate different types of marine life-sensing technologies: genomics, imaging-biooptics and participatory sciences. The technologies will be implemented in a co-design framework, involving all the interested stakeholders: academia, industry, civil society and government. The project proposes the concept of Operational Marine Biology (OMB), understood as a biodiversity information system for systematic and long-term routine measurements of the ocean and coastal life, and their rapid interpretation and dissemination. The production of FAIR Operational Marine Biology data will be carried out in a distributed IT infrastructure built from edge and cloud compute nodes, to be connected with the European Open Science Cloud (EOSC). The technologies will be tested and validated in different case studies, involving the ANERIS innovations, commercial instruments to be improved and different world-class research infrastructures (RI). The project will develop a training program for the operation and use of these new solutions for all the involved stakeholders and particularly the research infrastructures staff. Overall, the project proposes to benefit all the actors involved in the quintuple helix framework of innovation, promoting innovation and knowledge sharing among them: (1) the academy with new life-sensing technologies to use in research; (2) the industry with new technologies and methods to exploit; (3) the governments, with improved observational systems and data products to be used in  environmental management directives; (4) the civil society, empowered through the proposed participative technolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Idea of Animation: Aesthetics, Locality and the Formation of Media Identity' (IDEAOFANIMATION).

assistant: **Concept**

This project examines how changing notions of animated film emerged during the period of its consolidation, from the introduction of animated films in cinema programmes in the mid-1910s to the surge in interest in animation and the global prominence of Walt Disney studios in the 1930s. The project investigates how a changing cultural and aesthetic identity of animated film was negotiated within films and articulated in the discourse surrounding cinema. As a new medium, animated film was marked by shifting understandings of its identity, with animated films themselves often experimenting with and reflecting on the form. Sometimes situating themselves within contexts of modernity and modernism, animated films negotiated the place of animation as a medium within a wider cultural and social field. Animation was also closely entwined with other media and arts; in addition to live action film, music, comic strips, illustrated books and theatre all played a prominent role in the constitution and development of animated film. Further shaping its identity, the reception and discourse of animation – including marketing, theorizations and discussions in the popular press – contributed to an emerging sense of what animation was, what it could (or should) do, and what its place in a wider context of visual culture entailed. In order to trace these various facets of animated film, the project will focus on three of the most significant national contexts of exhibition and production during the period: the United States, England and France. This will allow for a comparative examination of ideas of animation, linked to national and transnational spheres of production, exhibition and reception. In doing so, the project will develop new approaches to the historiography of animation that e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ROOF INTEGRATE, GRID CONNECTED PHOTOVOLTAIC SYSTEMS FOR ENERGY EFFICIENT SOCIAL HOUSES IN LIMBURG' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of the project is to realise the first demonstration in Belgium of grid connected roof-integrated photovoltaic systems on residential buildings. This is a part of a global project which aims at building 30 social houses with very low energy consumption. A minimisation of BOS costs is aimed through the use of prefabricated mounting structures and by using latest string inverter technology.On 15 energy efficient houses a grid connected roof-integrated photovoltaic system of 1.3 kWp will be installed. It will include passive solar aspects and solar thermal systems. The PV array is mounted on the south oriented roof with a tilt angle of 30 to 60 degrees for optimal yearly output. The array consists of 1 string of eleven 83 Wp panels connected in series, feeding a 700 W (AC side) inverter. In this way, cabling costs and installation costs are reduced to the minimum, while cheap, highly efficient inverters have been developed and are commercially available.The PV panels are mounted on the roofs using plastic construction elements. The DC wiring connections between the panels are incorporated in the structures hereby, making it a prefabricated construction element.The PV panels, will be connected to the grid between the kWh counter of the houses and the main distribution grid. All the installations will be monitored according to the JRC guidelines. Additional parameters to evaluate the roof integration will be traced. It is foreseen to perform special measurement campaigns to investigate specific topics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploring the Mechanobiology of the Secretory pathway across scales'.

assistant: **Innovation**

Membrane trafficking is fundamental to cellular homeostasis, controlling essential processes ranging from signalling to adaptation to the environment. By regulating secretion, eukaryotic cells modulate plasma membrane composition and the extracellular matrix. Human cells are typically embedded in tissues and constantly experience external forces. While the molecular details of the secretory pathway are well-established in 2D cultures, their response to mechanical cues remains largely unexplored.This project aims to fill this knowledge gap by investigating how the Golgi complex, the central hub of the secretory pathway, responds to external mechanical forces. Using cutting-edge microscopy, biomaterials, and advanced cell biology, our study will adopt a bottom-up approach. First, we will explore the fundamental biology of the secretory pathway mechanotransduction in 2D polarized and non-polarized cells. Employing super-resolution microscopy and single-particle tracking, we will analyse how external mechanical forces influence Golgi dynamics with unprecedented spatiotemporal resolution. Our second aim extends this research to 3D systems, hypothesizing that inherent forces in these environments affect the secretory pathway. By leveraging colorectal cancer patient-derived organoids, we aim to uncover changes in secretion under mechanostimulation. This project will pioneer single-particle tracking in 3D imaging, integrating expertise from cell biology, optics, and photonics—a synergy uniquely supported by the host institution.Colorectal cancer, a prevalent and deadly malignancy, suffers from limited therapeutic options due to cellular heterogeneity. By bridging cell biology and biophysics with cancer research, this project holds the potential to identify novel vulnerabilities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Impact of structural heterogeneity on solute transport and mixing in unsaturated porous media' in the context of a Horizon 2020 call.

assistant: **Objectives**

Solute transport in unsaturated porous media plays a crucial role in environmental processes affecting soils, aquifers, and carbon capture and storage operations. Natural porous media are characterized by various degrees of structural heterogeneity in the pore size distribution, spatial arrangements and spatial correlations. The impact of this pore-scale heterogeneity on the spreading of a solute plume, its mixing with other solutes, and the resulting reaction rates, is not well understood for unsaturated flow. Since these processes take place at pore scale, direct pore scale experimental measurements are needed to gain comprehensive understanding of them. The aim of UnsatPorMix is thus to elucidate the impact of structural pore-scale heterogeneity on solute spreading/mixing and reaction rates during unsaturated flow, through the combination of micromodel experiments and numerical model simulations. In the first stage of UnsatPorMix, experiments in micromodels with varying degrees of heterogeneity will provide unprecedented results on the phenomenology of pore-scale mechanisms and their effect on solute spreading and mixing. In the second stage, the experimental measurements of phase distribution and solute concentrations, combined to numerically-computed pore scale velocities, will be used to design and validate a pore-scale model for solute transport in these porous media. This model will allow obtaining a large representative numerical data set, enabling statistical analysis and the derivation of quantitative relations between structural heterogeneity and solute transport/mixing. UnsatPorMix will make a significant contribution to the modelling of, and risk assessment for, the various subsurface phenomena and applications cited above. During UnsatPorMix, the applican
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Redefining Boundaries: Artistic training by the guilds in Central Europe up to the dissolution of the Holy Roman Empire' (ARTIFEX) targeting Seventh Framework.

assistant: **Abstract**

Based on wide-ranging sources, the project studies artistic training in pre-modern Central Europe. Up to the end of the Holy Roman Empire, the study area experienced various sizes with changing borders and different linguistic areas and jurisdictions. The project explores these aspects, referring to current research on culture-historical geography. Moreover, it will examine and, in some cases, revise the one-sided negative image of the guilds, using the example of research into historical networks and components of the dynamism of personal associations developed by neighbouring disciplines: Guild structure is viewed at times as an all-embracing, tightly knit network that permitted artists to exchange ideas and move freely and establish art markets.The cross-border research approach thus complements for the first time the historical idea of the artist as a model in social history. Up to about 1800, the artist was part of the hierarchical European society; except for the court artist, he was an artisan bound to the guilds. Numerous attempts to institutionalise artistic training and transfer it to academies succeeded only when the guilds were dissolved under Napoleon. An edition of all German-language guild and artisan regulations in Central Europe will make a hitherto little noted source type of major relevance accessible to research. One aim is to assemble a critical corpus of historical sources structured according to cities, a second, to analyse the social historical contexts, among them, synergy effects of “artistic knowledge” and training practices, the artist’s social and territorial mobility and the gender-specific inclusions and exclusions in pre-modern workshop operations. In terms of globalisation, the project can overcome topographical, methodological and conte