RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum control of levitated massive mechanical systems: a new approach for gravitational quantum physics' in the context of a Horizon 2020 call.

assistant: **Objectives**

Quantum physics and general relativity are probably the most successful and well-tested theories of modern science. At the same time, their fundamental concepts are so dramatically different that there is disagreement on the most obvious questions such as “how does a mass in a quantum superposition state gravitate?“. Achieving progress on such foundational questions requires experiments at the interface between quantum physics and gravity, of which to date only a few of exist. The main objective of the proposed research is to establish quantum control of levitated massive objects as a new paradigm system for such experiments and to enter a hitherto inaccessible parameter regime of large mass and long quantum coherence.The proposal builds on the enormous recent success in quantum control of the motion of solid-state mechanical resonators, which has emerged over the last decade as a new branch of interdisciplinary research in quantum and solid-state physics. Applied to optically or magnetically levitated systems this methodology promises (i) exceptional sensitivity to weak gravitational forces, hence enabling measurements of gravity between sub-millimeter objects; (ii) unprecedented levels of decoupling from the environment, thereby opening up a new route for long-lived quantum coherence of genuinely massive systems. Quantum control is achieved by coupling the motion either of optically trapped particles to an optical cavity field or of magnetically trapped particles to superconducting circuits. We will explore both methods for systematically expanding the available parameter space of macroscopic quantum systems and for first proof-of-concept experiments aimed towards addressing fundamental questions of gravitational quantum physics.If successful, this research program wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Costs and Gains to Postponement: How Changes in the Age of Parenthood Influence the Health and Well-being of Children, the Parents, and Populations'.

assistant: **Innovation**

Advanced maternal and paternal ages are associated with a range of negative offspring outcomes, and have been estimated to have population-level health effects comparable to those of obesity. This project analyses the health and well-being consequences of fertility postponement, focusing on three previously unanswered questions. Project A assesses the causality of the advanced parental age-offspring outcomes association. The existing literature is largely associational. Using innovative methods that allow me to control for previously unanalysed factors, I test the causality of this association and produce new estimates for the population level health impact of advanced parental age. Project B focuses on the role of the environment. Since health improves over cohorts, can postponement of parenthood – which means that the child is born to a later cohort – improve offspring outcomes? Moreover, does the environment influence the young parental age effect on the offspring? Project C analyses the implications of postponed parenthood on parental subjective well-being, which is critical for both child and parental health, but has not been analysed before.Each of the three sub-projects has the potential for producing ground-breaking results with important policy implications and large impact on both demography and on other disciplines. Project A either confirms that the social process of fertility postponement is an important public health threat, or shows that the health effects of postponement have been grossly overestimated. Project B may revolutionise the way postponement is seen: if the cohort trend hypothesis is found to be true, the assumption that postponement has a positive effect on offspring outcomes at the individual level will be confirmed. Project C provides an inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Drug discovery screening using human neurons' under Horizon 2020.

assistant: **Concept**

Brain disorders present a staggering health-care burden, costing around 800 billion euros per year in the EU and affecting almost 180 million people. Currently, development of treatments for these disorders is very unsuccessful. Of all currently prescribed drugs, >30% target G-protein coupled receptors, that are typically activated by neuromodulators. Neuromodulators are signaling molecules secreted by most neurons, which regulate many processes in our brain and body. Dysregulation of neuromodulator secretion is firmly associated with many neuropsychiatric disorders, but no screening assay for neuromodulator secretion is currently available to test drug candidates.  We have developed a human-based neuromodulator screening assay for preclinical testing of compounds for neuropsychiatric disorders. This assay, the HumanNeuronScreen, uses human neurons derived from somatic patient cells (e.g. skin), to maximally approach the situation in the patients’ CNS and thereby greatly enhancing target validation and lead optimization in preclinical research. It delivers in depth knowledge on the mechanism, potency and selectivity of drug candidates, supporting a higher success rate for clinical trials. Therefore, the value proposition of our product consists of a drastic reduction of costs in drug-development for pharmaceutical and biotech companies, and potentially impacts on 180 million patients in Europe. This proof-of-concept project aims to prove the commercial potential for the HumanNeuronScreen by measuring a reference library of compounds that establishes the resolution, reproducibility and dynamic range of the screen.  An IP strategy will be developed to ensure a market position and business strategy will be created and validated. Together, this maximizes the value of the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health.'.

assistant: **Objectives**

Pregnant women who are overweight/obese have increased risks of adverse perinatal outcomes, and of having offspring who are subsequently overweight/obese. A potentially important consequence of this is that it will drive the obesity epidemic across generations. Evidence from animal models supports this, but it has not been explored in humans. Furthermore, we need to know the mechanisms linking maternal adiposity to adverse offspring and next generation outcomes in order to develop preventive interventions. I will use data from up to 100,000 participants from nine cohorts and two consortia to determine the effects of maternal pregnancy levels of adiposity and associated circulating nutrients  on levels of adiposity and cardiometabolic health at three periods of the lifecourse: (i) fetal development, (ii) infancy to adulthood and (iii) in the next generation. My team is world leading in this area, and we will use state-of-the-art methods to advance the field by: (i) assessing a larger number of maternal nutrients than previously; (ii) accurately assessing maternal gestational fat deposition; (iii) determining the effects of maternal exposures on fetal fat and lean mass, and metabolic response; and (iv) measuring outcomes into the next generation. Effects will be replicated in several independent cohorts and triangulated across different state-of-the-art statistical methods: (i) cross-cohort comparisons between European and low and middle income country cohorts, in which confounding structures differ; (ii) comparisons of associations of maternal exposures to equivalent associations of paternal exposures, under the assumption that intrauterine effects are maternal specific; and (iii) Mendelian randomization using genetic variants as unconfounded proxies for maternal exposur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NESS Dual Hybrid Systems – Cost-effective CO2 solutions to increased Vehicle Electrification and Efficiency' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

NESS is the most efficient and cost-effective dual hybrid (electric- fuel) solution and reduces 13-18% vehicles fuel consumption, CO2- and NOx emissions. It also converts fossil-fuelled gasoline- and diesel cars into Hybrid Electric Vehicles (H-EVs) ready for 100% climate neutral renewable fuels, such as e-fuels, H2 gas and 2nd gen biofuels. NESS converts both new- and existing cars as a plug n play retrofit product conversion. It consists of an add-on component that goes attached to the engines alternator and turbocharger, forming a fully modular solution adaptable to all types of engine- and vehicle sizes. The savings are attained thanks to various functionalities that reduce the consumption of the vehicle in different ways depending on the drive mode the vehicle runs; exhaust gas energy recovery works at cruising, regenerative breaking when breaking, energy boosting functions at accelerating and stop & start functions when the vehicle is stationary.


**Keywords:** Hydrogen gas driven vehicles,fossil fuel free vehicles,cost effective vehicle electrification,waste heat energy recovery,dual hybrid systems,renewable- & electro-synthetic fuels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Control of Host Mechanics by a Bacterial Pathogen and Functional Impact' to be submitted under Horizon Europe.

assistant: **Abstract**

Mammalian cells sense and exert forces on their environment, and their responses to mechanical signals regulate their growth, motility, and behavior within tissues. However, little is known about the forces at play during microbial infections, and their impact on tissue homeostasis and disease progression. I recently found that binding of the extracellular bacterium Neisseria meningitidis (Nm) on the endothelium leads to the generation of large traction forces on the extracellular matrix. This is due to the formation of a new structure, that I called ancreopodia, linking the bacterial colony on the apical side of the host cell to the basal side and underlying substrate. I hence hypothesize that Nm induces long-range force transmission throughout the infected cells, leading to alterations in tissue function.In this project, I propose to dissect how host cell mechanics is affected by Nm infection, and how mechanical forces globally impact tissue barrier physiology in epithelia and endothelia. By developing quantitative tools to directly measure forces while imaging host cells during infection, both in vitro using 2D and 3D models of tissue barrier with increasing complexity and in vivo, I will: 1) identify the key molecular mechanisms involved in host cell structural remodeling and their regulation in space and time; 2) characterize the mechanics of the infected host tissue, using biophysical tools and theoretical approaches to link signaling to the forces involved, and 3) study the functional consequences of infection-induced mechanical imbalance on cell fate and host tissue integrity. This study has a double interest: to better understand the impact of mechanics in the process of infection, for the development of new therapeutic strategies, and to bring new fundamental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Modelling, Fault Management, Verification and Reliable Design Environment for Cyber-Physical Systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In IMMORTAL, a consortium of leading European academic and industrial players aim at combining their expertise in developing an integrated, cross-layer modelling based tool framework for fault management, verification and reliable design of dependable Cyber-Physical Systems (CPS). Recently, the world has seen emerging CPS modelling frameworks addressing various design aspects such as control, security, verification and validation. However, there have been no considerations for reliability and automated debug aspects of verification. The main aim is to fill this gap by introducing reliable design and automated system debug into CPS modelling. To reach this aim, the project will develop a cross-layer CPS model spanning device (analogue and digital), circuit, network architecture, firmware and software layers. In addition, a holistic fault model for fundamentally different error sources in CPSs (design bugs, wear-out and environmental effects) in a uniform manner will be proposed. Moreover, IMMORTAL plans to develop fault management infrastructure on top of the reliable design framework that would allow ultra-fast fault detection, isolation and recovery in the emerging many-core based CPS networked architectures that are expected to be increasingly adopted in the coming years.As a result, the project will enable development of dependable CPSs with improved reliability and extended effective life-time, ageing and process variations. In line with the expected impacts of the Call, the project will have a significant impact in development time as well as maintenance costs of dependable cyber-physical systems.The tool framework to be developed will be evaluated on a clearly specified real-world use-case of a satellite on-board-computer. However, since the results are more gener
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smart Integration of Genetics with Sciences of the Past in Croatia: Minding and Mending the Gap' (MendTheGap).

assistant: **Concept**

This project is an innovative opportunity to mend several gaps in the research capacity in Croatia in Archaeology, Genetics, and other ‘Sciences of the Past’ by twinning a consortium of Croatian researchers (CrEAMA Initiative) with archaeological scientists from the University of Cambridge (UCAM) and the University of Pisa (UP). The project exploits location-specific advantages that arise from two crucial facts. Firstly, there is large number of archaeological sites and remains in Croatia that are relatively understudied. Secondly there is a group of researchers (CrEAMA Initiative) whose research capacity, impact, and grant success at the European level has not realised full potential owing to a relative lack of resources, coordination, and strategic planning. This project will unlock this latent scientific potential by developing multi-inter-trans- disciplinary (MIT disciplinary) expertise. Our ultimate vision is to develop a research group capable of using an MIT disciplinary approach to Sciences of the Past; this will be a powerful force for innovation and will contribute to resolving contemporary issues. This vision will be realised through support from our partners: the UCAM and the UP. Both institutions display success in Archaeology, Genetics and other Sciences of the Past, and have proven track records in applying for and completing EU-funded research projects. The first goal is to establish and integrate the existing MIT disciplinary scientific research community in Croatia. The second goal is to upgrade and intensify scientific research of CrEAMA Initiative by utilising recent methodological achievements in genetics (NGS) and other biological disciplines (GMM). The third goal is to foster integration of the CrEAMA Initiative into ERA. Our last goal is to comme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Molecular Communications for Internet of Nano-Things'.

assistant: **Objectives**

The Internet-of-Nano-Things (IoNT) paradigm has the potential to dramatically transform society and is recognised as one of the top 10 emerging technologies by the World Economic Forum. In order to connect nano-scale devices, this timely fellowship will focus on molecular signalling, which underpins multi-scale coordinated biological actions. Despite its prevalent nature, we do not yet understand the information carrying potential of molecular signals in complex and multi-scale fluids, nor do we know how to design credible communication protocols. Inspired by these challenges, the objectives of this fellowship are: (1) bridge fluid dynamic and communication theory knowledge by combining complex fluid dynamic experiments with molecular communication testing, and (2) design and test innovative capacity achieving communication protocols in complex diffusion-advection environments. The experienced applicant and the scientist-in-charge have the joint ambitious vision to achieve fundamental understanding of the underpinning science through the co-creation of inter-disciplinary knowledge. The project will provide career accelerating training and knowledge transfer and enable the applicant to become a world leader in molecular communications and create sustainable societal impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulation of gene dosage on the mouse X chromosome' to be submitted under Horizon Europe.

assistant: **Abstract**

Differences in gene dosage can be as powerful as to drive species evolution (e.g., whole-genome duplications) and as harmful as to lead to human diseases (e.g., aneuploidies or haploinsufficiencies). Regulating the effects of gene-dosage differences is thus extremely critical, and this is paradigmatically illustrated by what happens to the X chromosome in mammals. In XX individuals, one of the X chromosomes is transcriptionally silenced as a result of a developmental and epigenetic process called X-chromosome inactivation (XCI), which is presumed to have evolved to compensate X-linked gene dosage between XX and XY individuals. Since its ‘discovery’ in 1961 by Mary Lyon, we have learnt much about XCI developmental dynamics and molecular underpinnings, however very little is understood about the developmental and molecular reasons at the basis of its evolution. REGULADOSIX aims to gain a functional and mechanistic understanding of the need of X-linked dosage compensation in mammals – we will (i) determine the developmental and molecular consequences in the absence of XCI in mouse embryogenesis, and (ii) functionally identify genes on the X chromosome that are dosage-sensitive, as well as their functions, which would have dictated the emergence of XCI in mammalian evolution. Building on my previous expertise, I propose a multidisciplinary approach at the intersection between development and genetic engineering, which includes cutting-edge genomic technologies (epigenetic screens, functional transcriptomics and proteomics) and novel approaches that we will develop to tune levels of expression in mouse embryonic stem cells and in mouse models. Besides bringing new insights into the need for dosage compensation between the mammalian sexes, REGULADOSIX will contribute to a qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial persuasion: cross-species triggering of biofilm dispersal as a competitive strategy in marine Bacilli', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The predominant mode of growth of bacteria in the natural environment is in biofilms. Although biofilm formation can be advantageous for bacteria, it has also some disadvantages, such as limited migration to an environment with fewer competitors or more nutrients. It is therefore not surprising that bacteria are not only form biofilms, but also are able to actively escape from the biofilm, a process called dispersal. Furthermore, in a competition between species, the production of signalling molecules that can actively induce the biofilm dispersal pathway of the competitors has evolved. In preliminary work, we observed that mature biofilms of a marine Micrococcus luteus strain and Escherichia coli could be dispersed by metabolites from a growing biofilm culture of a marine Bacillus licheniformis isolate. These results suggest that the dispersal of the M. luteus and E. coli biofilm may be an inducible, physiologically mediated process. This proposal aims to identify the compounds produced by the marine B. licheniformis EI-34-6, which brings about dispersal of the M. luteus and E. coli biofilms, and genes required for biosynthesis of these BDCs. Furthermore, we want to study the biofilm dispersal process on a single cell level using confocal scanning laser microscopy.