RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Chemical Tools for Unravelling Sirtuin Function' under Horizon 2020.

assistant: **Concept**

It was recently realized that lysine acetylation affects a wide variety of cellular processes in addition to the initially recognized histone related gene regulation. Together with recent groundbreaking results, revealing the presence of additional acyllysine modifications, the basis for a paradigm shift in this area was formed. Examples of enzymes formerly thought to be lysine deacetylases, have been shown to cleave these new types of lysine modification and members of the sirtuin class of enzymes play a central role.   Development of new tools to investigate the importance of these new modifications as well as the sirtuins that cleave them is required. We therefore propose to adopt an interdisciplinary approach by developing selective inhibitors and so-called activity-based probes (ABPs) and applying these to the investigation of proteins recognizing novel post-translational acylations of lysine residues in cells. Such ABPs will be powerful tools for providing insight regarding this rapidly evolving area of biochemistry; however, the current state-of-the-art in ABP design is endowed with severe limitations because the modifications are inherently cleaved by various hydrolases in human cells. Thus, in the present project, I propose that novel designs accommodating non-cleavable modifications are warranted to maintain structural integrity during experiments.    Furthermore, I propose to apply similar mechanism-based designs to develop potent and isoform-selective sirtuin inhibitors, which will serve as chemical probes to investigate links between cancer and metabolism, and may ultimately serve as lead compounds for pre-clinical pharmaceutical development. AIM-I. (a) Development and (b) application of collections of chemical probes for activity-based investigation of enz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'QUalitative Electricity STorage for Solar energy' (2014-2020).

assistant: **Innovation**

Lancey Energy Storage is pioneering a new era for energy storage, in which home appliances can contribute to the energy transition by storing electricity and engaging citizens. To fight global warming, renewable energy (RE) production is soaring, which is good news but has direct consequences on network management due to the intermittency of solar and wind power. Distributed storage can help better regulating the power grid and integrating more RE through self consumption and grid services. But few can afford it. Lancey aims at democratizing it by embarking a battery into a space heater. In France alone, 1/3 of real estate is electrically heated. Yet 1st generation electric heaters consume a lot of electricity and are highly responsible for the evening winter power peaks. Lancey has the solution to both of these issues. With its efficient heating technologies and energy management system, Lancey heater fine tunes to users’ needs while its battery charges off peak or with renewable energy surplus and discharges to prevent it from consuming power during peak hours. Total heating bill reduction can reach up to 50%. In 1,5 year of existence, Lancey has put on the market an innovative patented product rewarded by a CES Best innovation award. Yet this first version of the Lancey heater is still limited as its battery can only be used to power the heater. Solar QUEST’s purpose is to develop the V2 of Lancey heater, able to reinject power stored in the battery into buildings’ grid to power other devices. It will unlock Lancey’s participation to grid services and make it possible to maximise PV installations’ self consumption rate in summer too. With its Danish partner Tomorrow, Lancey will showcase the CO2 emissions its offsets, better engage users on energy transition and inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Capillary electrophoresis as a main pillar for the characterisation of nanoplastics released from single-use and reusable plastic drinking bottles'.

assistant: **Concept**

The advent of plastics to society has entailed a global dependence on this material. Special attention should be paid to nanoplastics, which are present in bottled drinking water due to weathering during usage. From a scientific point of view, it is important to get an insight into the risks that nanoplastics may bring to human health. Analytical Chemistry is called to provide a response to this actual problem with new methodologies to characterise nanoplastics that are released to water from commercial bottles. The main goal of CE4Plastics project is to advance the-state-of-the-art methods for identification and quantification of nanoplastics released to drinking water from single-use and reusable plastic bottles in the short and long-term and raise awareness in the population about nanoplastic risks. The feasibility of capillary electrophoresis to characterise nanoplastic particles will be investigated. Next, bottle weathering during normal usage and its implications in nanoplastic release to bottled water will be assessed. The project will be carried out at Flemish Institute for Technological Research (VITO), in Belgium, with an European researcher resuming his path in research and innovation. CE4Plastics will give him an excellent opportunity to be engaged in a wide range of transferable and scientific skills and to lead a necessary breakthrough to promote nanoplastic separation, quantification and position himself as a leading researcher in the future.


**Keywords:** Capillary electrophoresis, nanoplastics, water quality, analytical separation and detection techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Underwater Security' to be submitted under Horizon Europe.

assistant: **Abstract**

Maritime security, including the underwater, is of paramount importance to assure the smooth and safe transportation of goods and people to/from the EU ports, as well as to preserve uninterrupted operations of critical coastal-based/river-based/maritime infrastructures. Ships and maritime infrastructures need to be protected against all illegal acts through a) continuous 24/7 underwater security surveillance against potential intruders divers, hostile underwater vehicles and illicit/dangerous containers towed by ships, b) on-demand ships’ hulls scanning/inspection for the best possible detection/recognition/classification of strapped, attached, hidden or misplaced illicit (i.e. narcotics) and dangerous material, c) underwater inspections of ports’ entrances, seabed and docking places foundation for the best possible detection/recognition/classification of dangerous containers (i.e. CBRNE packages and IEDs) at these places, as well as to apply deterrent and response measures, in order to prevent/deter illicit acts and avoid undesired escalation of security incidents. To that end, the multinational and interdisciplinary UnderSec project team, consisting of experts in the maritime security and underwater security domain, research/academic institutions and technology, and End-Users from the Coast Guard, Borders Control, and Port Authorities sectors, will develop a modular/holistic approach Prototype System, consisting of multimodal sensors and robotic assets, for ships’, ports’ and maritime infrastructures’ Underwater Security Situational Awareness and Decision-Making Support, with relevant Response capabilities. Individual technologies will be tested, compared with each other and pre-evaluated in a controlled environment, while the modular components and the system as a wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cultural roots and institutional transformations of teachers’ careers and the teaching profession in Europe'.

assistant: **Objectives**

The teaching profession is central to a number of major issues concerning the possible futures of educational systems. The functioning of the profession suffers from low attractiveness, fragmentation, and teacher shortages. This proposal constitutes the first systematic comparative project in Europe aimed at understanding the role of the institutional dimensions affecting teachers’ careers and the teaching profession as a whole. It has four objectives: [1] to explain the nature of teacher policy over the last thirty years in different educational systems (Belgium, France and England); [2] to understand the changing status of the teaching profession and its impact on the diversification of the teaching workforce; [3] to analyse the processes by which teachers are allocated into increasingly diverse working and professional conditions; and [4] to model and predict teacher attrition and migration within a common but differentiated multilevel framework. This project will adopt a post-comparative mixed-method design organized around four work packages on teacher policy, supply, labour markets and mobility. It will combine five methods: policy analysis of teachers’ recruitment and careers; secondary data analyses of relevant national and international datasets on teacher supply and the profession’s attractiveness; a qualitative, in-depth study of three national labour-market spaces; multilevel multi-group analyses of original datasets on teacher mobility, and semi-structured interviews with non-entrants and early leavers.This project will produce new theoretical knowledge about labour markets for teachers and contribute to the reconceptualization of the nature of institutional change affecting educational systems in a society characterized by the progressive decline of nation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Behaviour of Aerosols Released to Ambient Air from Nanoparticle Manufacturing - A Pre-normative Study' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The NANOTRANSPORT project addresses the behaviour of aerosols released to ambient air from nano-particle manufacturing. The project brings together leading expert organisations in risk management, aerosol monitoring, filtration, nano-particle technology and online particle characterization fields. The proposed pre-normative study has the objective of bringing into light and to document the need for standardised test aerosols adapted to the scope of nano-toxicology and occupational health studies.State-of-the-art nano-article generation and aerosol monitoring equipment will be used to show that the properties (size, size distribution, surface chemistry, surface charge, concentration) of aerosols formed by manufactured nano-particles experience dramatic changes when released in the ambient air compared to their initial properties within the reactor.The project will provide introductory experimental results that will be used to develop recommendations and guidelines for the European Commission. Based on NANOTRANSPORT results, the Commission will have the necessary background to prioritise and initiate research to-Develop standard test aerosols adapted to specific studies/tests/validations/investigations:It will contribute to determine the toxicological and epidemiological hazards posed by nano-powders in a systematic way reflecting exposure levels likely to be encountered in industryNew standards and particularly adequate test aerosols for testing and guaranteeing suitability of filtration and respiratory protection for use in nanoparticles/ nanopowders production or processing sites will be identified and described.-Promote a more effective use of research funding by implanting correct methodologies that will contribute to provide meaningful and comparable results, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'POPULATION REPLACEMENT OR CONTINUITY?A GENOMIC CONTRIBUTION TO THE NEOLITHISATION DEBATE', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Neolithisation, that is the transition from a hunter-gatherer form of life into farming, began transforming Europe around 10,000 BP. In current Denmark, an area central to our understanding of this process, the Mesolithic Ertebølle Culture maintained a hunter-gatherer lifestyle until replaced by the Neolithic farming practices of the Funnel Beaker Culture around 6000 BP. However, it is has been intensively debated for more than a century whether this cultural transition was facilitated by diffusion of ideas, or by a population replacement, where migrating farmers claimed the land of hunter-gatherers. In one of the most ambitious DNA sequencing efforts ever undertaken on ancient remains, this project aims to characterise the Neolithisation. Complete mitochondrial genomes and thousands of informative sites in the nuclear genome (SNPs) will be profiled from at least 60 individuals, covering the Mesolithic-Neolithic transition in Denmark. This will result in a high-resolution, genome-wide survey of one of the most important and enigmatic events in human history. Importantly, sampling many individuals from a restricted geographic area provides a tight and powerful analytical framework in which to monitor micro-evolutionary shifts in the ancient human gene pool. By profiling functional SNPs (related to, for example, hair colour and lactose tolerance), physical traits in the population as a consequence of (possible) replacement can also be identified. Lastly, these genomic data will be analysed and interpreted in the context of stable isotopic profiles, 14C dates and tooth-wear analyses to generate a multi-facetted image of the Neolithisation. In addition to contributing with new information on our shared ancestral history as Europeans, this project will showcase the proli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimality Principles in Human Motor Control' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Understanding how the brain controls even the simplest movement is a major challenge due to the bewildering complexity of the sensorimotor and musculoskeletal system. For example, the large number of joints and muscles provide the human musculoskeletal system with numerous degrees of freedom.  As such, any motor task can be achieved via an infinite number of different muscle activation patterns. Yet, experimental studies show very consistent and stereotypical patterns of kinematics and muscle activation. Furthermore, to adequately control and execute movements, the brain needs accurate information about the state of the musculoskeletal system and about (its relationship with) the world around it. The brain receives information from the many sensory systems in the human body. However, this information is corrupted with noise that is inherent to processes in any biological (nervous) system.The proposed research is aimed at testing two influential theories in human sensorimotor control – ‘Optimal Control Theory’ and ‘The Uncontrolled Manifold Theory’- that try to explain how the brain deals with the many degrees of freedom. This will be done through a combination of computer simulations with a state-of-the-art neuro-musculoskeletal model of the human arm and new experimental designs using a unique exoskeleton robot. Furthermore, Bayesian Decision Theory has a great amount of success in explaining various phenomena in sensory-motor neuroscience. In the proposed research, this theory will be integrated with Optimal Control in combination with a detailed model of the neuromuscular plant. Specific predictions will be tested using a novel experimental design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Evolution of Pathogen and Host Diversity'.

assistant: **Concept**

The study of host-pathogen systems is of central importance to the control of infectious disease, but also provides unique opportunities to observe evolution in action.  Many pathogen species have diversified under selection pressures from the host; conversely, genes that are important in host defence also exhibit high degrees of polymorphism.  This proposal divides into two parts: (1) the evolution of pathogen diversity under host immune selection, and (2) the evolution of host diversity under pathogen selection.  I have developed a body of theoretical work showing that discrete population structures can arise through immune selection rather than limitations on genetic exchange.  The predictions of this framework concerning the structure and dynamics of antigenic, metabolic and virulence genes will be empirically tested using three different systems: the bacterial pathogen, Neisseira meningitidis, the influenza virus, and the malaria parasite, Plasmodium falciparum. The current theory will also be expanded and modified to address a number of outstanding questions such whether it can explain the occurrence of influenza pandemics.  With regard to host diversity, we will be attempting to validate and extend a novel framework incoporating epistatic interactions between malaria-protective genetic disorders of haemoglobin to understand their intriguing geographical distribution and their mode of action against the malarial disease.  We will also be exploring the potential of mechanisms that can organise pathogens into discrete strains to generate patterns among host genes responsible for pathogen recognition, such as the Major Histocompatibility Complex.  The co-evolution of hosts and pathogens under immune selection thus forms the ultimate theme of this proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pursuing Efficient Reliability of Object Detection for automotive and aerospace applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Autonomous vehicles are about to change completely the transportation systems, the automotive and military markets, and burst deep space exploration. However, while autonomous cars are expected to reduce of two-three orders of magnitude the number of traffic accidents  and burst space exploration, the current self-driving systems are not yet compliant with ISO26262 dependability requirements to be adopted in large-scale  and are not yet sufficiently reliable to be part of a space mission. In particular object detection, a critical task in autonomous vehicles, has been demonstrated to be highly undependable and to be responsible for the great majority of accidents in current self-driving cars prototypes.  “Pursuing Efficient Reliability of Object Detection for automotive and aerospace applications” (PERIOD) challenge is to improve the dependability of object detection frameworks in an effective and efficient way. PERIOD aims at analyzing and proposing solutions to overcome the software and hardware dependability issues of object detection. By correlating computing architectures and software reliability analyses with the impact of faults in the vehicle behavior, PERIOD aims at reducing the probability of misdetection without the time, power, and cost overheads that make traditional fault-tolerance solutions unsuitable for automotive or aerospace real-time systems. The proposed action will enable a highly interdisciplinary collaboration between the experienced researcher, a talented associate professor with a significant track record in computer science and computer engineering, and the supervisor, a world leader in test, embedded systems, and computing architectures for automotive/space applications whose group is embedded systems in one of Europe’s leading research insti