RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploitation of enzyme promiscuity to generate ribosomal natural product diversity' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Natural sources have been highly important for the discovery of new drugs, offering compounds that possess exciting and potent bioactivities. The development of many promising natural products is significantly hampered by the difficulties associated with the synthesis of novel analogs. The family of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products offers a plethora of different, promising bioactivities and highly diverse scaffolds. I propose to develop two new complementary routes to generate modified, bespoke RiPPs in vitro and in vivo: Interchangeable leader peptide (ILP) technology, which is a novel approach tailored to RiPPs. Every RiPP is produced from a precursor peptide that consists of a core peptide (the eventual natural product) and a pathway-specific recognition sequence that is recognized by parts of the biosynthetic machinery. ILP technology will allow me to swap out recognition sequences and thus combine the biosynthetic machineries from diverse RiPP pathways in a mix-and-match approach to generate new-to-nature, hybrid RiPPs using two routes: (1) We will develop this technology in vitro to take full advantage of non-natural amino acids and other building blocks. (2) We will transfer an optimized, streamlined version to an in vivo setting using peptide ligation in the cytoplasm of E. coli. This will allow us to use the power of genetics to create large libraries of compounds. I will harvest the novel enzymatic modifications enabled by ILPs to generate diverse RiPP scaffolds that contain amino acids, non-natural amino acids, enzymatically modified amino acids and non-a-amino acid building blocks. We will then use ILP technology to identify novel pathoblockers for Pseudomonas aeruginosa. The successful completion of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'High performance neural network signal processing schemes for wireless terrestrial and satellite transmissions'.

assistant: **Innovation**

The aim of this project is to propose new Neural Network based methods for adaptive equalisation of the satellite UMTS transmission channel. The use of roof top Adaptive Antennas will also be studied within the frame of the project. Objectives are to evaluate the performance issues related to the use of Neural Networks equalisation techniques and to compare with classical equalisation implementations. The technical feasability of the implementation of Neural Network based equalisers will be studied, especially at UMTS terminal level.During first year a simulation tool for down link non-linear satellite channel has been implemented.Second year will be devoted to the study of Neural Network based algorithms and to the demonstration of the viability of such algorithms for the implementation of simple equalisers to be used over non linear UMTS satellite channels. It is expected that the proposed methodology will lead to unexpensive implementation, hence favouring the emergence of unexpensive dual mode (terrestrial satellite) terminals.Expected ImpactImpact on future UMTS air interface standardisation.Deployment of satellite UMTS will take advantage of unexpensive and efficient equalisation techniques. Also, satellite resource optimisation will lead to more cost efficient S-UMTS systems deployment.Main contributions to the programme objectives:Main deliverablesA testbed including emulation of a complete S band satellite transmission chain including a novel equalisation module, based on neural networks.Contribution to the programmeValidation of Neural Network algorithms for equalisation of a satellite channel at S band.Technical ApproachFor adaptive equalisation of non-linear satellite channels, artificial Neural Networks (NN) have shown their ability to solve various problem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Frontiers: Rural Spaces and Expanding States' (EUROFRONT), addressing dissemination and exploitation.

assistant: **Impact**

Frontiers are dynamic zones of resistance and negotiation where local actors respond to the political/economic fluctuations of expanding states. Research on Europe’s frontier zones in the historic past has immediate relevance to the modern economic and political landscape, where the expansion of transnational markets is creating new dynamic frontier zones. Yet due to the typical top-down approach employed by archaeologists and historians, the local experience of living in a frontier has been largely overlooked. EUROFRONT adopts an innovative four-field methodology (archaeology, history, geomatics, and ethnography) to investigate two European frontiers in Crete and Dalmatia. Rich datasets will be developed for each region, synthesizing archaeological data, archival materials (e.g. tax registers and cadastral maps), paleoclimate data, and modern oral histories about villages in the regions. Advanced geospatial analyses will be used to detect patterns in population movement, settlement distribution, network connection, and agricultural production. During the project, the researcher will be trained in cutting-edge geomatics technologies, and the skills and knowledge she gains will enhance her reputation as a leading scholar of Early Modern archaeology and history in Europe. Results of the study will provide insight into how frontier communities are shaped by the process of state expansion from an economical, social, political, and environmental perspective. Project dissemination will prioritize publication of the raw data, training other scholars, and sparking an international dialogue about frontier zones that transects geographical and temporal boundaries. The project website and interactive online GIS will be critical deliverables that not only promote the study of front
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Study of proteins involved in herpesivirus neurotropism'.

assistant: **Concept**

-To determine the role of herpesvirus glycoproteins in viral neurotropism.-To examine the role of other viral proteins involved in penetration, propagation or persistence in the nervous system.-To undertake a structural study of selected herpes proteins involved in neurotropism.We propose to elucidate which viral functions are necessary for alphaherpesviruses to penetrate and propagate in the nervous system. We plan to address this question both in vitro, in polarised cells and in primary cultures of neurons, and in vivo in suitable animal models, using appropriate mutants in which the gene of interest will be deleted. Our first objective will be to analyse the role of the external proteins of HSV1, PrV and VZV virons in the viral neurotropism. Our previous work has led to a better understanding on the role of five of the eleven herpes glycoproteins. We now plan to examine the role of the six other glycoproteins, by comparing the neurotropism of deletion mutants with that of wild type or rescued viruses, after intranasal inoculation of mice.In addition to envelope glycoproteins, we will also examine other viral proteins which could play a role in neurotropism. Proteins UL 3.5 and UL 20 of PrV have been demonstrated to be involved in the egress of virions from the nucleus to the cytoplasmic membrane. Since this process is poorly understood in neurons but is important for transneuronal spread, respective mutant viruses will be analysed in vitro and in vivo. Protein IE63 of VZV is expressed in large amount during latency in neurons of rat and man. It is also expressed during productive infection in cell cultures, in the skin during zoster and in sensory ganglia during reactivation. Hence its exact role is unclear. Using transient expression assays, it has been shown that I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'GlycoGold: Exploration of the nature and potential of Glyco-nano-particles' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of the RTN is to explore the potential of gold Glyco-Nano-Particles (GNPs), to deepen the understanding of bio-molecular interactions and to solve biomedical problems. The innovative combination of a variable metallic core with a selected set of ligands can turn GNPs into vaccines or anti-adhesion agents or dedicated vehicles to deliver compounds safely at their target location. GlycoGold will operate as a virtual research-training centre at the interface of physics, chemistry, immunology, molecular biology, and bioinformatics. It integrates and expands the knowledge base and infrastructures of the partners. It has work packages (WPs) that deal with materials, tools and insight into bio-molecular interactions, and WPs geared towards the application of GNPs as vaccines, and control of interactions.The Training&Mobility and Design&Innovation WPs and active networking ensure a smooth project workflow. The tasks are assigned to international task forces. The research is timely, because the required techniques have evolved to a point that an integrated multinational approach is viable. Secondly, interest of industries in obtaining this information is high. Thirdly, the necessary overall knowledge to perform the research in a single laboratory does no t exist in Europe, and very few graduates have the integrated knowledge to operate in this area, despite the large demand for them.The network provides an interdisciplinary training environment for these specialists, where training is offered through:(i) handson experience,(ii) summer schools aimed to bridge the knowledge gap between the physical and life sciences,(iii) short courses, lectures, demonstrations and practical training sessions, and(iv) activities for individual career development.Dedicated international and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Semantic Data Platform for Healthcare' (SEMCARE) targeting Seventh Framework.

assistant: **Abstract**

The aim of SEMCARE is to build a semantic data platform to support clinical trials. The platform will identify patient cohorts based on patient-level criteria (e.g. age, gender, diagnosis, indication, symptoms, lab results) scattered in heterogeneous clinical data. As most of patient-level data is unstructured, language technologies are necessary to extract and exploit the relevant data. Our platform combines the power of full text search with text analytics and semantic web technologies for a hybrid semantic full-text search. It will enable semantic integration of different data sources for information extraction, document retrieval, analytics and visualization.<br/>SEMCARE addresses the ever growing need to exploit medical data from clinical trials and for monitoring and improving healthcare delivery. The platform has the potential to provide for a more efficient, scalable method of patient recruitment for clinical trials; up to 80% of clinical trials fail to meet their patient enrolment quotas on time and SEMCARE will help prevent this. Recruitment delay currently causes up to $8 million per day in loss of revenue for the biopharmaceutical industry. The platform will also be capable to detect undiagnosed patients with rare diseases based on sign and symptom combinations. This has the potential to speed up the research on this group of diseases, which constitute a highly attractive market for pharmaceutical companies, up to 300,000 USD drug revenue per year and patient.<br/>The SEMCARE consortium includes passionate players from the demand and supply sides. Hospitals in three different European countries serve as pilot sites and have particular interests in applying SEMCARE in their clinical research activities. The SMEs AVERBIS and SYNAPSE have a clear interest in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Decoding Peptide-Mediated mRNA Decay: Uncovering the Role of Nascent Polypeptides in Gene Regulation'.

assistant: **Concept**

Cells tightly regulate mRNA stability to ensure accurate gene expression across diverse cellular states and conditions. Traditionally, selective mRNA degradation has been attributed to the recognition of nucleotide sequence elements by proteins or small RNAs that subsequently recruit decay factors. Conversely, an emerging mechanism termed “peptide-mediated mRNA decay” (PMD) involves the encoded protein: my postdoctoral work revealed how the nascent polypeptide—physically linked to the mRNA during translation by the ribosome—can direct mRNA decay. This process is exemplified by tubulin mRNAs, which are selectively degraded when cells sense excess free tubulin levels. In this novel type of regulation, a recognition factor binds the nascent polypeptide to recruit downstream factors that trigger mRNA degradation. Impaired tubulin PMD results in severe phenotypes like defects in cell division and neurodevelopment. Beyond tubulins, emerging evidence points to critical PMD mechanisms targeting transcripts encoding aggregation-prone proteins. I postulate that PMD represents an entirely unexplored paradigm of gene regulation that dynamically adjusts protein production to ensure cellular fitness. However, the mechanistic understanding of PMD is still limited and the full range of substrates remains unknown.In DECODE-PMD I will unravel how nascent polypeptides direct mRNA degradation on ribosomes and chart the transcriptome-wide map of PMD substrates. Specifically, I aim to (1) decode how mRNA translation and degradation are coupled during tubulin PMD using a biochemical reconstitution approach; (2) decipher the physiological triggers of tubulin PMD and its regulation; and (3) harness advanced sequencing methods to systematically identify PMD substrates and derive common mechanist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fostering Artificial Intelligence Trust for Humans towards the optimization of trustworthiness through large-scale pilots in critical domains' in the context of a Horizon Europe call.

assistant: **Objectives**

The increasing requirement for trustworthy AI systems across diverse application domains has become a pressing need not least due to the critical role that AI plays in the ongoing digital transformation addressing urgent socio-economic needs. Despite the numerous recommendations and standards, most AI practitioners and decision makers, still prioritize system performance as the main metric in their workflows often neglecting to verify and quantify core attributes of trustworthiness including traceability, robustness, security, transparency and usability. In addition, trustworthiness is not assessed throughout the lifecycle of AI system development so developers often fail to grasp a holistic view across different AI risks. Last, the lack of a unified, multi-disciplinary AI, Data and Robotics ecosystem for assessing trustworthiness across several critical AI application domains hampers the definition and implementation of a robust AI paradigm shift framework towards increased trustworthiness and accelerated AI adoption. To address this critical unmet needs, FAITH innovation action will develop and validate a human-centric, trustworthiness optimization ecosystem, which enables measuring, optimizing and counteracting the risks associated with AI adoption and trustworthiness in critical domains, namely robotics, education, media, transport, healthcare, active ageing, and industrial processes through seven international Large Scale Pilots. Notably, cross-fertilization actions will create a joint outcome, which will bring together the visions and specificities of all the pilots. To this end, the project will adopt a dynamic risk management approach following EU legislative instruments and ENISA guidelines and deliver tools to be widely used across different countries and sett
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Coastal Surveying of Depths with EGNOS to Enhance Charts'.

assistant: **Innovation**

The objective of the project is to create a system for enhanced surveying of coastal waters through using standard navigation equipment, as an alternative to the standard approach of using specialist Hydrographic surveyors and high precision instruments. Instead, we use a large amount of data logged by vessels carrying out their normal business, and later uploaded to our server for processing. By using a large amount of data, the errors from using less accurate instruments can be remoed. We believe this can be developed to provide a cost effective system that will enable much of the shortfall in surveys to be made up.The benefits of this are safer navigation to all vessels in coastal waters, in particular to the leisure, fishing and workboat sectors, and also greater information for the GIS community, coastal engineers, port, harbour and waterway authorities, and applications such as tide power or offshore wind farms.The system will use GPS receivers equipped with EGNOS to provide the required level of positional accuracy, and will use statistical techniques to remove errors from depth measurements from echo sounders that cannot otherwise be resolved.The data logged will be available both as survey data and as chart data. It will be made available in the IHO S-100 format, which is suited to chart creation by Hydrographic Offices and to the wider GIS community, including use in OGC Web Map Servers and Web Feature Servers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Unified modelling language for component design' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

CAS is a software house, developing Mapware and Groupware products for the mass market. With Map&Guide we are the European market leader for professional route planning. It was a strategic decision of the top management of CAS, to adopt the component approach and appropriate methods, to deal with reusability of our modules. Though object oriented design methods are well established and well tested, their successful application in small companies for component design and development is not yet proved. Therefore, we want to measure the efficiency of such techniques on a baseline project taken from our key business line, before promoting them in the whole company. Our goals in UNCODE are:to improve reusability and quality of our source code,to increase the efficiency of our software developmentto achieve full commitment of the participating staff members,to improve the maturity of our development processTHE EXPERIMENTWithin UNCODE we will apply the Unified Modelling Language (UML) to Map&Guide, an in-house continuously developed geographic information system, involving basic system, map kernel and application developers. Map&Guide will be restructured in 1997 to become the first fully component- and service-oriented geographic information system in Europe. This significant evolution stage will be the baseline project for this experiment. The integration of the UML in our development process and it's correct application/use for component design & development will be supported by the Forschungszentrum Informatik (FZI) with teaching and consultancy.EXPECTED IMPACT AND EXPERIENCEFrom the software engineering point of view we expect after a successful completion of UNCODE:Design improvement: more flexible, adaptable, maintainable and compatible productsQuality improvement: meas