RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Improving vaccination in early life'.

assistant: **Innovation**

The objectives of Neavac-Ec are :1) to increase knowledge of immunological factors which, in early infancy, lead to a high susceptibility to infectious diseases and to relatively weak vaccine-induced responses;2) to define optimal vaccine design and new immunization strategies for the rapid induction, in early life, of protective vaccine responses and long lasting immunological memory; 3)to identify and standardize suitable evaluation procedures (in vitro/in vivo, animal models/human, Dendrite Cell (DC), T and B cells responses) for the initial assessment of future vaccines/ delivery systems/ adjuvant considered for use in early life. A Tran disease approach has been adopted, focusing on(I) analysis of the Maturation of early life immune responses in humans and animal models and(ii) optimisation of vaccines against 3 selected important early life pathogens (S.pneumoniae, B. peruses, Respiratory Syncytial Virus). This should contribute to establishing the generic principles of early life immunization and promote their concrete application to the industrial development of vaccines of high priority for both human and veterinary diseases.The overall achievements of Neovac have been more extensive that what could be expected. Substantial progress has been made towards a better understanding of the basic aspects of immune responses to vaccines in the neonatal period, particularly at the level of dendritic cells, opening the way to the design of appropriate vaccine formulations. In addition, results of considerable practical importance were obtained:- A new vaccinations strategy has been defined that may open the way to neonatal prevention of early life Pertussis.- Innovative immunisation approaches that are based on novel adjuvants, new formulations or new carriers were shown
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Micro-Inductive Based Biosensor Arrays for Very High Sensitivity Detection' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Detection of biological agents is critical in many fields related to public health, foods industry, environmental control, water management and clinical and diagnostic analysis. In these fields there is an important need for the development of biosensor systems with low cost, high sensitivity and specificity, ease to transport for in-situ measurements, short analysis time and simple operation (easy handling). All these demand for the development of micromachined devices based in magnetic immunoassay techniques. In this project, microcoils are proposed as inductive transducers for the development of very high sensitivity and low cost biosensor arrays for the above-mentioned wide range of applications. This requires a previous assessment step in order to validate the ability of standard Si micromachining technologies for the proposed devices. Detection of biological agents is critical in many fields related to public health, foods industry, environmental control, water management and clinical and diagnostic analysis. In these fields there is an important need for the development of biosensor systems with low cost, high sensitivity and specificity, ease to transport for in-situ measurements, short analysis time and simple operation (easy handling). All these demand for the development of micromachined devices based in magnetic immunoassay techniques. In this project, microcoils are proposed as inductive transducers for the development of very high sensitivity and low cost biosensor arrays for the above-mentioned wide range of applications. This requires a previous assessment step in order to validate the ability of standard Si micromachining technologies for the proposed devices.OBJECTIVESThe main objective of this project is the development of micro-inductive Biosensor ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biodiversity Building Blocks for policy' (B3).

assistant: **Innovation**

The world is changing rapidly; climate change, land use change, pollution and natural resource exploitation are creating a global crisis for biodiversity whose magnitude and dynamics are hard to quantify. Decision makers at all levels need uptodate information from which to evaluate policy options. For this reason rapid, reliable, repeatable monitoring of biodiversity data is needed at all scales from local to global. Only by leveraging large volumes of data, advanced modelling techniques and powerful computing tools can we hope to synthesize these data within timescales that are relevant to policy.Data on biodiversity come from a diverse range of sources, citizen scientists, museums, herbaria and researchers are all major contributors, but increasingly new technologies are being deployed, such as automatic sensors, camera traps, eDNA and satellite tracking. Integrating these data is a major challenge, but is necessary if we are to create dependable information on biodiversity change. B3 will use the concept of data cubes to simplify and standardize access to biodiversity data using the Essential Biodiversity Variables framework. These cubes will be used, in conjunction with other environmental data and scenarios, as the basis for models and indicators of past, current and future biodiversity. The overarching goal of the project is to provide easy access to tools in a cloud computing environment, in real-time and on-demand, with state of the art prediction models of biodiversity, that will output models and indicators of biodiversity status and change. The project envisages a future where primary biodiversity data are seamlessly integrated into monitoring and forecasting such that policy and management can proactively respond to problems while at the same time reduce th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biological performance testing methodology to evaluate the durability of plywood as a quality indicator for exterior construction purposes' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Plywood is the wood based panel product showing the best physical and mechanical properties for application in constructions even more valid under moist circumstances and load-bearing applications under exterior conditions. The mechanical and physical criteria to be met for construction purposes in general and more specifically for outdoor applications are well defined. The required biological durability however is not totally clear. Suitable laboratory fungal test methods have been developed giving reproducible results in line with testing of the biological durability of solid wood and the test methods used for efficacy determination of wood preservatives. The standard test method according to ENV12038 needs to be validated as a method to predict actual suitability of plywood products in applications under hazard class 3 conditions according to EN 335.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Twinning excellence on organic soil amendments effect on nutrient and contaminant dynamics in the subsurface' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

TwinSubDyn aims to establish a research knowledge hub at UNSPMF, Serbia, on the impacts of organic soil amendments (OSA) on the fate of contaminant-, and nutrient dynamics in the soil subsurface and implications for groundwater quality. The project will significantly boost research and innovation capacities of UNSPMF, through a twinning action with internationally-leading research institutions in this research field from Europe, i.e. UNIVIE, FZJ, MLU and IRNAS-CSIC. The strategy for stepping up and stimulating scientific excellence and innovation capacity for our TwinSubDyn defined research topic is based on: (1) Networking for Excellence - through transfer of knowledge, best practice and expertise during secondments, between UNSPMF and the aforementioned research institutions; (2) Establishment of long-lasting strategic partnerships with leading European research organisations; (3) Raising the EU and global research profile of UNSPMF and its staff - through delivering lectures by experts, short-term on-site training, organization of workshop/summer school and strengthening the research management and administration unit at UNSPMF; (4) Development of Science and Innovation Strategy and key action planning in the TwinSubDyn field for UNSPMF; (5) Spreading scientific knowledge through the available multiple dissemination channels, and finally (6) Increasing overall competence via the strategic collaborative consortium TwinSubDyn research project and its intrinsic knowledge exchange and gains.


**Keywords:** environment, soil, groundwater, organic amendments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CORPORATE ORGANISATIONS INTERACTIVE NETWORK SYSTEMS' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

COINS is developing a telematics network to bring fast efficient communications to European SMEs (small and medium-sized enterprises). The network will use teleservices to enable SMEs and chambers of commerce to exploit multimedia training for distance learning. Video-conferencing will enable SME staff to attend courses from their own company rather than having to travel to centralised locations. The SME staff will be able to have face-to-face training with trainers located at a distance and to take part in group training sessions. This project will boost SME training in remote regions and also make these regions more attractive to industry.The Corporate Organisations Interactive Network Systems (COINS) Project aims to develop a telecommunications network which will allow SMEs (Small and Medium sized Enterprises) across Europe to communicate in a fast and efficient manner. The COINS project will provide networked access to training centres and will promote the use of teleservices in communities to enable both representative community users (such as Chambers of Commerce) and SMEs to avail of multi-media training and information systems. The system will test on-the-job training programmes using training materials which will be accessed over the telematics network. The project will use video-conferencing facilities to provide face-to-face training on a multi-point basis. This will enable SME learners at their own business premises to take part in group training sessions without having to travel to centralised training centres The elimination of this necessity to travel will be one of the main benefits of the COINS project. This will be of particular benefit to SMEs located in more remote regions of Europe, as they can be integrated into mainstream activities through the us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design and synthesis of novel inhibitors of the anti-infective target IspE', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Due to the current antimicrobial resistance crisis, addressing underexplored targets to afford anti-infective compounds with novel modes of action is urgently needed. Antimicrobial resistance not only poses a threat to public health, but is a substantial cost burden on the healthcare system. This proposal focuses on the design and synthesis of novel inhibitors of the target 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (IspE). IspE catalyzes the fourth step in the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway which is essential for medically relevant pathogens (e.g., Enterobacter coli, Klebsiella pneumoniae, Mycobacterium tuberculosis and Pseudomonas aeruginosa) but entirely absent in humans, making this enzyme a promising drug target. We will initially explore drug fragments through the screening of carefully constructed fragment libraries, followed by hit-to-lead optimization for promising compounds. Target confirmation will be performed using a biologically active small-molecule photo-crosslinking probe and a crystal structure of IspE obtained in complex with a promising inhibitor. The investigation of potential for therapeutic intervention via inhibition of IspE will result in several potent inhibitors, enhancing the knowledge of this underexplored enzyme target and opening up access for further exploration of potent inhibitors. This research will greatly contribute to the discovery of novel anti-infective agents, leading to decreased morbidity and mortality in patients, economical benefits for the health care system in the European Union as well as globally.


**Keywords:** anti-infective, IspE, Hit-to-lead optimization, fragment growing, methyl erythritol phosphate pathway
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'High-resolution tweezers for DNA replication and sequence identification'.

assistant: **Concept**

We propose to investigate the enzymes responsible for DNA replication and repair in micromanipulation experiments with a resolution of a single base. The detailed mechanism by which DNA is synthesized base after base and the coordination of the enzymes involved in this process are not fully understood. We shall develop new magnetic tweezers using lithographic techniques associated with evanescent field detection to address these issues. We shall build arrays of these devices working in parallel, each one on a single DNA molecule and where the measurement of its extension reveals enzymatic activity. The DNA molecule in these devices will form a hairpin the opening of which can be detected with a single base resolution.We will study the different enzymes involved in DNA replication. Firstly, we wish to follow in real time the incorporation of bases one by one by a DNA-polymerase and investigate the proof-reading mechanism of this enzyme. We shall also investigate the translocation mechanisms of different helicases involved in DNA replication and repair. Finally, we plan to study the cooperative action between different enzymes involved in the replication machinery with the help of parallelized micro-tweezers: the coupling between helicase and primase in the lagging strand synthesis, the coupling between the helicase and polymerase during leading strand synthesis and the coordination between leading and lagging strand synthesis.Moreover observing a DNA-polymerase at the single base level is the first step of a DNA sequencing method. Preliminary experiments demonstrate that the unzipping assay is a new way to determine the position of a small DNA sequence with single base resolution. We shall investigate different experimental schemes to achieve this goal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CONFINED CATALYSIS IN LAYERED MATERIALS – A TRANSFORMATIONAL APPROACH FOR EFFICIENT WATER SPLITTING' to be submitted under Horizon 2020.

assistant: **Abstract**

Sustainable solution for global energy crisis is firmly associated with seeking energy sources other than fossil fuel. In this respect, the production of hydrogen through water splitting (WS) has been regarded as the greenest approach to power the globe. At present, the issue of realizing active and stable material capable of catalyzing WS in all pH ranges is unsolved. CoCaWS aims at exploring new efficient catalysts for overall WS to tackle the problem of global energy crisis through ecofriendly hydrogen production. I hereby propose to study a new class of efficient catalysts based on composite two dimensional (2D) layered nanomaterials. I employ the concept of confined catalysis, catalytic activities taking place in a unique nanoscale environment partitioned from the surrounding bulk space, to ensure long term efficient production of H2 from water. The van der Waals (vdW) gaps between the layers will serve as a suitable platform to confine another active species. Through this approach, I aim at solving the most critical problems in the field such as catalytic functionality in neutral media for metals or alloys and poor basal plane activity in layered 2D materials. I will make use of the most conducive research environment in UNIVE to acquire new skill/knowledge and broaden my basic knowledge on advanced characterization techniques and data interpretations. The knowledge of physical chemistry, material science, condensed mater physics, and computational chemists will be involved to confront with the complexity of the task through smooth interaction with researchers in the Department of Molecular Sciences and Nanosystems of UNIVE. The project, up on completion, will provide a significant stepping-stone in the quest for responding the escalating demand of greenest energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Precipitation of monohydrate alumina in the Bayer process' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives The production of alumina by the Bayer process involves three main steps: digestion of bauxite, precipitation of aluminum trihydrate (gibbsite, Al2O3.3H2O) from the resulting solution and calcining of the gibbsite at 980 - 1200oC to produce alumina. The calcination step absorbs 3 GJ/t alumina or 25% of the total Bayer process. The objective of the current project is to develop a highly innovative modification of the Bayer process, whereby aluminum monohydrate (boehmite, Al2O3.H2O) rather than the trihydrate will be the product of the precipitation stage. This will result in significant energy savings, estimated to 1.8 GJ/t alumina or 60% over the current practice at the calcination stage because (a) the enthalpy of dehydration of boehmite to alumina is lower by 1.1 GJ/t alumina compared to that of gibbsite, and (b) the quantity of material to be calcined will be reduced by 20% per t alumina, as only one rather than three moles of water are associated to one mole of alumina. Technical Approach Initially chemical modeling of the system H2O-Na2O-Al will be carried out and the stability area of boehmite and gibbsite as well as the solubility of boehmite in sodium hydroxide solutions will be determined as a function of temperature and alkali concentration. Based on the above, the precipitation of boehmite from aluminate liquors will be studied experimentally; the effect of a number of parameters such as precipitation temperature and time, concentrations, quantity and quality of seed, on the physical properties of the product and on the extent of the reaction will be investigated in detail. A mathematical model will then be developed to describe the precipitation of boehmite combining thermodynamic and kinetic equations with material, energy and population balances