RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Central archive for empirical social reaerch (ZA)' under Fifth Framework.

assistant: **Concept**

The Central Archive for Empirical Social Research (ZA) serves as resource centre for European Social Research by supporting access to nationally and internationally comparative data sets and facilitating empirical analysis on the background of relevant culture specific interpretation knowledge. The ZA holds more than 4000 data sets and data collections. Even though there is no particular restriction, emphasis in gathering data is on topics such as political attitudes, election studies, education, unemployment, leisure and occupation, media and environment. More than 400 data sets from surveys conducted in the former GDR since 1975 were included in the holdings and were processed for secondary analyses.A series of electoral surveys from emerging democracies in Eastern Europe is added to the holdings in cooperation with the Wissenschaftszentrum Berlin. Training in complex analysis methods takes place twice a year in the ZA Spring Seminar for Empirical Social Research and the Autumn Seminar for Quantitative Historical Research. The ZA is the European centre for integrating the EUROBAROMETERs, the International Social Survey Programme (ISSP) and major election studies in Europe (ICORE). Expertise can thus be provided in data management and analysis of complex databases as well as expertise in the area of acquisition, processing, documenting and making available social scientific data.Application:Main Results: 50 researchers comprising 1000 access days were expected to profit from EU support within the contract. In the end actually 1161 access were used comprising 49 projects with 87 researchers. 88% of the access days granted were used by researchers who had not used the ZA-EUROLAB previously.Project Manager:Ekkehard Mochmann, Bachemer Str. 40, Cologne 50931, P.O. BOX 41096
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Functional characteristics of allergen-specific T lymphocytes in nickel-induced allergic rhinitis' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Allergy to nickel is a frequent health problem that affects as many as 60 million people in Europe and poses a considerable burden to the EU economy. In order to gain a better insight into the nature of the disease, this laboratory-based project will be carried out on nickel-specific T-lymphocytes ¿ cells playing a key role in initiating the disease.Particular attention will be paid to differences between lymphocytes involved in two different clinical forms of nickel allergy: nickel-induced allergic rhinit is (Ni-AR) and nickel-induced allergic contact dermatitis (Ni-ACD). The working hypothesis is that these lymphocytes express different homing antigens and/or chemokine receptors that allow them to migrate and initiate inflammatory processes in particular organs, i.e. in the nasal mucosa or the skin.In order to verify this hypothesis, lymphocytes of patients with Ni-AR, Ni-ACD, and healthy controls will be studied for their functional characteristics (cytokine secretion) and the presence of molecules involved in lymphocyte homing. This project is an extension of the research carried out within the applicant's current Marie Curie Individual Fellowship and will enable him to transfer the newly acquired knowledge and laboratory techniques to his country of origin.The reintegration host has a long experience in nickel research and provides health care to many patients with Ni-AR and Ni-ACD, which will provide a good opportunity for recruiting volunteers to donate blood samples needed for this study.The expected results will provide a better understanding of the mechanisms of nickel allergy and will be a first step towards the development of an in vitro method for the diagnosis of nickel rhinitis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'District of the Future' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Cities are increasingly recognizing the need of addressing climate and energy challenges. The District of the Future (DoF) project is a project funded by the European Union (EU) with the objective to increase energy efficiency in a city district using innovative Information and Communication Technology (ICT) approaches. It will help city leaders to achieve quantifiable and significant reduction up to 30 to 40% of energy consumption and CO2 emissions and will improve citizen awareness and people involvement.The project will be executed by a consortium formed by a world leader in integrated telecommunications, technological consultancy firms, ICT software and equipment providers, SMEs, a Research and Development organization, energy companies and the public authorities of the cities of Sabadell (Spain), Orléans (France) and Corby (UK) that will provide the real life environment for the project.DoF will use ICT to collect, register and monitor energy data and bring this to a cloud-based software platform. This platform will analyze energy patterns in each city district. That will allow predicting energy consumption and energy production behavior in each district. DoF will provide a system based upon standardized state-of-the-art communications, that will support city authorities and citizens in taking the right decisions in order to optimize energy systems and improve energy efficiency in the involved city districts.The project will contribute to the adoption of green ICT technologies by city authorities. Just by reapplying the DoF approach in other European city districts the project will make a sustainable contribution to the objectives of EC 2020 Energy and Climate Change, 20% of energy from renewable, 20% increase of energy efficiency, 20% reduction of greenhouse gas e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Precautionary expertise for gm crops' to be submitted under Fifth Framework.

assistant: **Abstract**

For GM crops in Europe, this project will analyse how current practices -regulatory measures, expert judgements and stakeholder roles - compare to different accounts of the precautionary principle. These practices will be studied at EU level and in 7 member states. Users of the research will be involved through an advisory panel and scenario-analysis workshops. The project will build upon and integrate earlier studies of public attitudes, risk regulation, precaution and deliberation. Using the analytical results, the project will suggest how official guidelines and expert bodies could be made more appropriate for addressing the policy problems, which the EU faces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Study of lung cancer risk and residential radon exposure'.

assistant: **Innovation**

Epidemiological studies of underground miners have shown that exposure to radon and radon progeny increases the risk of lung cancer. However, there are uncertainties in using these data to estimate the risk associated with radon exposure in dwellings. In contrast, information from case-control studies of residential radon and lung cancer in the general population are directly relevant as inputs to the formulation of radon remediation and lung cancer prevention programmes. The overall objective of this project is to improve direct estimate of the risk of lung cancer from residential radon exposure. This will be done first by pooling together data from case-control studies that have been carried out in several European countries, and then by pooling the European data with similar data from studies carried out in North America. Furthermore, as well as making full use of exiting dosimetry based on alpha-track radon detectors, new dosimetry techniques based on measurements in glass will be evaluated. Based on these techniques, additional assessments of radon exposure will be made for a sample of individuals already included in the European studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design of adaptive artificial facette eyes, micro-optical fabrication using lithography, characterisation and application' (2002-2006).

assistant: **Concept**

Today we live in a world completely dominated by vision with a strong tendency to a constant increase of visual information. However, miniaturization of elements is done by applying similar optical principles known to the designers for many decades.Novel fabrication technologies are permanently developed and applied, but there is no consequent search for new vision principles to fully exploit the newly gained technological capabilities that allow completely new and unexpected fields of application. Main re search projects at the Fraunhofer-Institute are related to these topics.Based on a strong experience in optics engineering and a well-established facility of optical fabrication technology from macro- to nanoscale novel optical systems are developed. Recently demonstrated bio-inspired vision systems such as planar artificial compound eyes for ultra-compact image acquisition are just a first step in this direction.Within the proposed project, novel vision systems will be designed and manufactured applying electron-beam- and photo-lithography. The main focus of research is related to artificial receptor arrays on a curved basis. This is a highly demanding and at the same time promising topic not only for artificial compound eyes but also for the simplification of classical imaging systems.The major difference of natural and artificial image acquisition systems at this stage is the planar arrangement of the artificial receptor arrays compared to the curved geometry of the natural ones. This is the consequence of today's limitation to planar lithographic patterning technologies.The advantages of a curved basis compared to a planar one are obvious: There are the immanence of a large field of view, the avoiding of off-axis aberrations and declining illumination with increas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REcycling of low Value components using high purity pre-treatment, dIrecT recycling And green hydrometallurgical approaches for recycling of Lithium Ion and Sodium Ion BatteriEs' (REVITALISE), addressing dissemination and exploitation.

assistant: **Impact**

REVITALISE delivers a holistic solution for green, low-cost, and low environmental impact recycling of NMC (Hi-Ni), LFP and Na-Ion batteries, representing 85% of battery waste streams up to 2025. REVITALISE develops low-cost and green processes to recover a full range of battery materials, including NMC, LFP, Al, Cu, Li, graphite, fluorides, phosphates and plastics.Overall recycling rates of 91%+ will be proven at TRL4 for waste processed from post-production scrap and end-of-life battery black mass. REVITALISE will develop innovative pre-treatment technologies based on electrohydraulic fragmentation, ultrasonication and magnetic, and electrostatic separation that will achieve very high levels of material stream purity. This will enable commercially viable recycling of low-value parts. The approach will enable direct recycling of 40% of the cathode and anode active parts, with direct characterisation of the lithiation (or sodiation) being developed that will be used as a basis of a smart-reformation approach for reclaimed active materials. The remaining 60% being suitable for hydrometallurgical recycling based on leaching with green organic acids from food waste, such as vitamin C (ascorbates), vinegar (acetate) and citric acid (citrates) and inorganic acids produced from industrial wastes.A further innovation is the development of water remediation with Li recovery from all wastewater streams generated, through the implementation of polymeric nanocomposite membrane separation with direct Li recycling for Li in water concentrations down to 0.6mg/L.The recycled parts will be assessed for (closed-loop) battery and other secondary applications for precursors and semi-products by the industrial partner Verkor through reformulation and upcycling of battery materials and vali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Effect of transforming growth factor beta on proto-oncogenes, tumour suppressor genes and cell cycle regulators : growth arrest versus apoptosis' in the context of a Fourth Framework call.

assistant: **Objectives**

Regulation of normal development and tissue function is the product of a balanced interplay between the mechanisms that regulate cell division, differentiation and cell death. Whereas the molecular mechanisms leading to cell growth and their contribution to cell transformation have been extensively explored in the last two decades, much less is known about the mechanisms that inhibit cell growth, most particularly in function of the adhesion status of the cell. Furthermore, simultaneous activation of the growth stimulatory and growth inhibitory programmes may raise cellular conflict leading to cell death, both in normal as well as in tumour cells. The overall aim of this integrated proposal is to define the factors which modulate key genes in the control of cell cycle arrest and cell death. The proto-oncogene c-myc and the tumour suppresser gene p53 have been shown to be major players in the control of normal cell proliferation and the development of malignancies. Activation of c-myc in quiescent cells is sufficient for induction of DNA synthesis whereas, activation of p53 prevents entry of cycling cells into S phase, but also renders them susceptible to apoptosis. Recent evidence suggests that extra-cellular matrix plays a protective role against apoptosis. Interestingly, one of the key cell cycle regulators of the G1/S transit, cyclin A has an expression which is strongly induced by c-myc, but also dependent upon cell anchorage. TGFbeta, a pleiotropicytokine that negatively regulates cell growth of mainly epithelial cells, induces a subset of the immediate early genes, notably Jun B, and represses some of the cell cycle regulators, such as cyclin A, through a signal transduction cascade which is presently almost completely obscure. However, whereas growth factors stim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Biobased Low-carbon Infrastructure Solutions'.

assistant: **Objectives**

Current EU strategies, the climate action and the European Green Deal require infrastructure to be provided in an economical and environmentally responsible manner, reducing material use, embedded carbon and other impacts on the natural environment and ecosystems.  Innovative, low-carbon, sustainable solutions will therefore be needed for the maintenance an upgrading of ageing transport infrastructure facilities to meet future needs and the changing environmental loads due to climate change. Opportunities for transformative processes arise from advances in understanding and harnessing nature-based processes. The use of such processes in geotechnical engineering practice is relatively new and underexplored. Before industrial adoption field applications of the techniques are required to prove their practical viability, long-term sustainability and whole life costs. The aim of this research is thus to realise exciting new bio-based processes in situ as a viable, sustainable method of improving existing infrastructure earthworks. For this the UK railway network is used as a case study. The research comprises the development of exciting novel processes in the laboratory, their numerical modelling before upscaled application in the field, and a pilot field study application of the novel techniques on a railway embankment.  Following this, the techniques will be evaluated in terms of environmental impact and whole life costs. This will lead to practical guidelines for industry, fostering the transfer of new technologies to engineering practice in order to address industry and EU priorities for low-carbon nature-based solutions and bio-economy.


**Keywords:** sustainable development, climate action, ground improvement, biotechnology, biogeochemistry, materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Immunity to genetically characterised malaria infections. A comparisonbetween longitudinal studies in a West and an East African village experiencing different intensities of transmission' in the context of a Fourth Framework call.

assistant: **Objectives**

To compare the molecular parasitology and immunology of antigenic variation in P. falciparum malaria in an area of high transmission and hyperendemic malaria (Ghana, West Africa) with that in an area of hypoendemic, unstable malaria (Sudan, East Africa) and to discover whether parasite strategies for immune evasion by antigenic variation vary under different transmission conditions.Expected OutcomeBy the end of the study we will have basic epidemiological data on the period that individuals remain asymptomatically infected at each study site and quantitative data on whether parasite densities fluctuate or remain broadly stable during asymptomatic infections at each site. The length and densities of gametocytaemia will also be known. This epidemiological data will allow us to interpret the results of the concurrent immunological and molecular biological studies on typing the PfEMP-1/var genes (using RT-PCR and human phage display library generated antibodies) in the parasites isolated from symptomatic and asymptomatic individuals.This will allow us to assay if, and how frequently, the parasite population in the monitored asymptomatic infections is switching PfEMP-1 expression and whether asymptomatic individuals infected with an apparently genetically stable population of parasites show constant responses in mixed agglutination assays or whether these vary in concert with var gene switches.Such reagents and information will be essential for further studies on the role of P. falciparum antigenic variation in pathogenesis.* Cloning and sequence PfEMP-1/var genes and gene fragments from African P. falciparum samples to obtain reagents and develop assays for the analysis of the genetics of the PfEMP-1/var system and to test whether clonal antigenic variation associated with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering and Engineering the overlooked but Universal phenomenon of Subpopulations in BIOtechnology' to be submitted under Horizon 2020.

assistant: **Abstract**

Microbial bioproduction, despite being considered a paradigmatic sustainable alternative to petroleum-based chemistry, is often limited by low yields and productivities, which prevents commercialisation. It is generally known for all types of cells that genetically identical populations can form metabolically distinct subpopulations. This diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields. However, the universal phenomenon of subpopulations emergence has been largely overlooked, especially in biotechnology, due to technical difficulties. Now, thanks to recent developments in single cell technologies, in molecular understanding of microbial communities and in synthetic biology tools, we can begin to address this widespread and impactful biological feature.  I propose to explore the emergence of subpopulations in yeast and understand their implications in metabolism and bioproduction using and developing cutting edge synthetic biology tools. I aim to use that knowledge to develop novel engineered strains that lack the presence of undesired subpopulations and then use such homogeneous populations for bioproduction. The homogenised production will be investigated in both, monocultures and microbial communities. In DEUSBIO, I will set up an innovative framework to maximise the biosynthesis of high value molecules, with high potential to overcome current limitations.This project will shed light on the phenomenon of subpopulations, whose relevance goes beyond bioproduction, as for example, it has been associated with the origin of multicellularity. Increasing our knowledge about this matter will also have implications in biomedicine, as cell subpopulations are extremely important in the appearance of antimicrobi