RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEUROendocrine SENSor for Sudden Unexpected Death in Epilepsy (SUDEP) prediction and prevention' (SUDEP), addressing dissemination and exploitation.

assistant: **Impact**

NEUROSENSE proposes a novel and visionary technology resulting from the demonstration of the upstream role of arousal in the sudden unexpected death in epilepsy (SUDEP). SUDEP is a societal challenge for which there is neither prediction nor prevention. Research in the field has for long been refining classic concepts based on the cardiac, respiratory and autonomic nervous systems impairment. Our vision is different and based on the neuroendocrine processes of epileptic seizures and arousal, which are expected to be impaired in SUDEP. The NEUROSENSE project will develop the first SUDEP Medical Device (SMD) prototype supported by artificial intelligence (AI) to anticipate life-threatening seizures and trigger automatic emergency drug administration to prevent SUDEP. This represents the very first viable solution towards a societal-friendly management of epilepsy-derived mortality, thus enabling the prevention of SUDEP worldwide. This will be achieved through the combination of expertise and innovative ideas in epilepsy and SUDEP, biosensors for medical devices, animal models of epilepsy and SUDEP and mathematical modelling. To tackle the objectives of the NEUROSENSE project, a multidisciplinary group of European leading experts in key technological areas will ensure that the complete chain of value is enclosed in a multifaceted analysis. The high-risk character of this joint science and technology research is offset by the multidisciplinary nature of the Consortium, by strong and extensive preliminary data and by the high socio-economic gain resulting from its successful execution. Based in the new SMD technology, we will build a diverse portfolio of future projects that will result in a long-term benefit for people with epilepsy, their families, the economy and society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nature-Inspired Gold Catalytic Tools', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The study of biologically relevant processes heavily relays on “small molecules”. Thus, the demand for novel chemical probes is of highest importance not only for chemistry, but also for closely related disciplines such as biology, medicine or material science. As the construction of complex molecular architectures from chemical building blocks still remains a far-from-routine task, the development of methodologies to increase the control over chemical reactivity and achieve molecular complexity with higher levels of efficiency has become one of the frontier challenges of chemistry in the 21st century.NIGOCAT aims to substantially contribute towards this goal. The general objective of this proposal is the design, synthesis and application in catalysis of novel, nature-inspired gold(I) and gold(III)-catalytic tools able to mimic nature´s efficiency and exquisite taste for the synthesis and stereoselective functionalization of “small molecules”. The proposed research tackles three main challenges faced by current synthetic methods: 1. Efficient generation of structural complexity; 2. Selective C-H bond functionalization; 3. High levels of stereocontrol in asymmetric catalysis.We aim to streamline the construction of molecular complexity based on modular, unprecedented multi-center gold factories. Our hypothesis is that the assembly of different reactive sites within a single catalyst will provide an increased level of efficiency in gold-orchestrated catalytic cascades from simple starting materials, thus mimicking the way nature assembles its complex primary metabolites. Second, we aim to tackle the flexible, selective functionalization of C-H bonds using novel metaloenzyme-inspired ligands on gold. Third, we aim to develop novel gold peptide-based catalytic systems as ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'P450 2003' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Cytochromes P450 (abbrev. P450) are the most important enzymes of metabolism of drugs, environmental pollutants and many toxicants as chemical carcinogens (e.g. polycyclic aromatic hydrocarbons, nitrosamines). On the other hand, the P450s are also involved in many vital functions in the body such as in the biosynthesis of steroid hormones, prostaglandins or thromboxanes. Hence, the importance of this subject for understanding of molecular mechanisms of processes involved e.g. in hormone biosynthesis, drug metabolism or in the activation of chemical carcinogens is crucial.This Conference is focussed ( i) on the insight into the nature of structure/function relationship of the P450 enzymes, (ii) on the role of understanding molecular mechanisms and the processes involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spatial miRNomics in Glioblastoma: Mapping the Unseen and its Clinical Significance' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Glioblastoma is the most common and aggressive brain tumour, with an 85% mortality rate within two years of diagnosis. In Europe, tens of thousands of people die from glioblastoma every year, and currently there are no effective treatments. Glioblastoma tumours exhibit high genetic and phenotypic heterogeneity with numerous cancer subclones. This complexity complicates the identification of useful clinical features across patients, highlighting the importance of studying glioblastoma from the perspective of its heterogeneity. MicroRNAs are small, non-coding RNA molecules that regulate gene expression post-transcriptionally. They play an important role in glioblastoma, where their dysregulation can drive tumour development. In addition, microRNAs hold potential as biomarkers, with the unique duality of acting both as targetable molecules and deliverable drugs, offering new opportunities for diagnosis and treatment. However, to date, no imaging method has achieved multiplexed mapping of microRNAs in tissues, resulting in a gap in understanding their spatial distribution within key tumour regions and how they contribute to glioblastoma heterogeneity.Spatial miRNomics is a pioneering concept that will, for the first time, map the spatial distribution of microRNAs in single cells and across glioblastoma tissues. Funded by the Marie Skłodowska-Curie Actions, Spatial miRNomics will extend spatial biology to microRNAs to close that gap, revealing their landscape in brain tissues, and their clinical significance in glioblastoma. This multidisciplinary effort will be performed at Mats Nilsson's Group (Stockholms Universitet), pioneers in spatial biology, and conducted at SciLifeLab, in the Karolinska Science Park. SciLifeLab excels in spatial omics with strong research, clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovation capacity building in Ukrainian SMEs and enhancing cooperation with European SMEs' (EEN-Ukraine).

assistant: **Innovation**

The overall / general objective of this proposal is to increase innovation potential and innovation management skills withinSMEs in the all regions of Ukraine and to assist SMEs with potential for international growth via product, process, service orbusiness model support. The project will follow a defined methodology to help regional businesses to increase theirinnovation capacity, to innovate profitably and also to successfully implement their innovative ideas on the competitivemarket. The EEN-Ukraine Consortium intends to enhance innovation capacity of SMEs by encouragement their participationin Horizon 2020 projects and provision of KAM services to SMEs which implement H2020 SME Instrumentprojects (or FTI and FET-Open ). The secondary target group will be R&D organisations that will benefit from EEN services as well. The specific objectives for reaching the overall / general objective are as follows:- promote and support SMEs from Ukraine in participation on the H2020 SME Instrument and COSME programmes;- identify weaknesses in the innovation capacities of the beneficiary that hinder the realization of growth opportunities and ofthe full commercial potential of SME Instrument participants;- identify suitable coaches to address the identified weaknesses and moderating the coach-client relationship;- increase the innovation potential of SMEs lacking professional support in the field of innovation management;- help SMEs to select the most appropriate coach;- explain and sell the benefits of the SME Instrument's coaching service to potential beneficiaries;- facilitate the SME- coach relationship and ensure the effective teamwork and co-operation between the SME;- secure close cooperation links between the Consortium and the H2020 National Contact Point, regional stakeho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'AVIATION RESEARCH ECOSYSTEM ADVANCED NOVEL APPROACH' (AREANA) under Horizon Europe.

assistant: **Objectives**

The AREANA project addresses the call for ""Aviation research synergies between Horizon Europe, AZEA and National programs"" by providing advanced novel approaches to foster the European aviation research ecosystem. It encompasses three interconnected, yet thematically distinct parts.Firstly, approaches improving on the coordination of aviation funding programs will be addressed by coordinating and supporting synergies between European, National, and Regional R&I aviation programs. The project aims to facilitate joint calls or other co-funding mechanisms that align EU, National, and Regional activities in specific fields and accelerate the update and sharing of aviation technology infrastructures in the European Research Area.Secondly, the upcoming Aerodays will be prepared. The consortium suggests them to take place during the first half of 2025 in Warsaw, Poland. They would then coincide with the Polish presidency of the Council of the European Union.Thirdly, AZEA (Alliance for Zero Emission Aviation) activities will be supported by conducting mappings and analysis, including the identification of potential technological and administrative gaps and lack of related R&I and standardization efforts, removing the obstacles for zero-emission aviation. Close cooperation with the Advisory Council for Aviation Research and Innovation in Europe (ACARE) and other institutions is expected.The AREANA project will help to sustain and foster the European aviation research ecosystem, thus helping to achieve the environmental goals while ensuring European competitiveness. This will be achieved by connecting and aligning different funding mechanisms, bringing together aviation stakeholders during the Aerodays and supporting the Alliance for Zero Emission Aviation.""


**Keywords:** av
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pulsed eddy current inspection system for pipeline health monitoring' in the context of a Horizon 2020 call.

assistant: **Objectives**

ETHER NDE Limited aims to commercialise PRECISE, an eddy current technology based inspection product for pipelines. The PRECISE device enables fast inspection of bond integrity, calculation of remaining wall thickness, examination of different pipe geometries, and inspection of non-steel and bare steel pipes. PRECISE technology eliminates the need to purchase multiple devices for inspection of pipeline assets, as the technology is able to inspect through every composite material used to reinforce pipelines. PRECISE will help prevent spillages from happening through early non-destructive detection; potentially preventing serious disasters and will reduce the negative impact of 280 gas leaks per year resulting in over €100 million in damages.The objective of this project is to perform Phase 1 feasibility study will allow us to analyse the technical feasibility assessment and evaluate the commercial potential of PRECISE product that we want to commercialise and exploit in the NDT inspection market by taking advantage of already validated system at TRL6. During this feasibility study we will perform risk assessment, market studies, intellectual property assessment and business planning with the ultimate goal to commercialise and introduce PRECISE product on the market, through innovation in key enabling technology as Eddy current.Our targeted market of NDT inspection services sector generated €295.4 million in revenue in 2012 and is expected to generate €494.4 million in 2017 with a CAGR of 10.9%.Realistically, it is estimated that our turnover through PRECISE commercialisation will reach over €8.5M by 2023, generating profits of €6M in the same year creating 14 new jobs extra for us by 2023.Considering we are Eddy current based product specialist company, this product is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Anticipating stochastic differential equations' (1994-1998).

assistant: **Innovation**

Research objectives and content This research project aims at deriving existence and uniqueness conditions for solutions to anticipating stochastic differential equations. Furthermore Markov properties of the solutions will be examined. Basically two methods will be used: the theory of enlargement of filtrations and spatial transformations. A tool for describing such transformations will be the approach of Russo and Vallois to stochastic integration. Training content (objective, benefit and expected impact) The research project is strongly based on the pathwise point of view of stochastic integration. This is a central feature in the approach of F. Russo (Paris XIII) and P.Vallois to stochastic calculus. Benefit is also expected from the cooperation with scientists of the university Paris XIII working on relevant fields such as Wiener analysis, infinite dimensional stochastic differential equations and Besov spaces. Links with industry / industrial relevance (22) Anticipating stochastic differential equations are likely to have some impact on the investigation of financial markets. F. Russo has regular contacts with banks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'People under Pressure: Settlement Abandonment and Human Responses to Environmental and Socio-Economic Stress during the Medieval and Post-Medieval Periods' (ABANDONMENT).

assistant: **Innovation**

The ABANDONMENT project explores the pan-European phenomenon of settlement desertion and shrinkage, which occurred especially during the 14th and 17th centuries. Despite considerable attention being paid to this particularly rich aspect of archaeological records (within several disciplines), the process of abandonment still remains poorly understood. The project aims to explore how rural communities and the settlements they lived in responded to socio-economic and environmental stress. The specific objectives are: (a) to determine the processes of settlement shrinkage and abandonment across England; (b) to contextualise changes in settlement patterns within wider transformations of land-use within distinct regions in the longue durée perspective; (c) to explore the cultural and environmental context of settlement evolution (and extinction) across northern and central Europe to determine the impact of these factors on communities.  This interdisciplinary research programme will bring together well-published and especially unpublished data from excavations and fieldworks. These will be supplemented by aerial photographs, LiDAR data, documentary evidence, historical maps, field-names and palaeoenvironmental data, with their collection and analysis via a GIS. This comparative, multi-scale research covers contrasting areas in the UK that were meaningful in the past in terms of their settlement pattern, geographical conditions and economy (the moors of the South West England, East Anglia, the claylands of the East Midlands and the North East of England), and tests the outcomes in broad geographical context through a comparison with Continental Europe.The fellowship in the University of Exeter, with the largest group of landscape archaeologists focusing on the historic period
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elongator role in light-induced gene expression – from upstream activators to gene targets and mechanism behind the regulation of RNAPII transcription elongation' (LightEr) under Seventh Framework.

assistant: **Objectives**

Elongator is a histone acetyltransferase (HAT) complex associated with RNA polymerase II (RNAPII) to facilitate transcription elongation. It consists of subunits Elp1-6 with Elp3 conferring HAT activity. Elongator is conserved in yeast, plants and humans. In humans, mutations in Elp genes cause neuronal diseases. In plants, Elongator is a positive regulator of cell proliferation during leaf and root growth. Elongator mutants have altered auxin signaling and responses to abscisic acid. Elongator regulates expression of specific genes, such as the light-regulated auxin response regulator IAA3/SHY2 and the clock regulator LHY during RNAPII transcription elongation. In addition, Elongator mutant seedlings show an altered light response and resemble triple phytochrome mutants. The working hypothesis is that Elongator acts as interface between phytochrome signaling and gene expression during transcription elongation to regulate processes such as the shade avoidance response. Different light qualities (low and high red/far red ratios) and seedlings of Elongator mutant or recombinant lines will be used to explore light-related Elongator target genes, pathways and interactors. In a first objective, light-regulated genome-wide targets and pathways of Elongator will be determined using microarrays, chromatin immunoprecipitation (ChIP-on-chip or ChIP-Seq) and iTRAQ proteome analysis. In a second objective, interactors of Elongator involved in light signaling and their target-specificity will be identified using tandem affinity purification, transient split-luciferase in vivo assay and ChIP-PCR. Genetic interactions between Elongator and light signaling mutants will also be investigated. In the third objective, the mechanism of Elongator action will be studied using ChIP-qPCR to che
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HYdrogen combustion: Pressure effects On combustion and THErmoacousticS' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The need to shift to carbon-free energy generation is impelling, but renewable energy sources such as wind and solar are intermittent. Significant storage and additional energy sources are needed to guarantee continuous supply of heat and power. To limit global warming, these sources need to be carbon-free/neutral. Hydrogen represents a promising alternative in future energy generation. It can be produced using renewable sources by electrolysis from excess energy or by gasification, stored, and then converted in highly efficient gas turbines delivering electrical energy and heat in peak demand periods. But it does not come without challenges. Hydrogen has unique combustion properties that differentiate it from traditional natural gases. They dramatically affect flame dynamics and combustion stability, particularly at the high-pressure conditions at which gas turbines operate. HYPOTHESis supports the paradigm shift to a carbon-free society by developing greater fundamental and applied understanding on combustion dynamics and control of pure and highly-enriched hydrogen flames and enabling future gas turbines to be operated at up to 100% hydrogen content. We will perform an extensive experimental campaign using our medium-pressure combustor to enable single stage hydrogen combustion at high pressure. Using both physics and machine learning based methods, novel models will be developed for predicting and controlling the dynamical behaviour of hydrogen flames. This will lead to (1) the understanding of the dynamics of hydrogen combustion, with a focus on the scaling of its properties at high pressure, for which little is yet known; (2) the establishment of new design strategies, thermoacoustic prediction methods and control tools that are of paramount importance for practic