RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gastro-intestinal Peptides in Obesity' (GIPIO), addressing dissemination and exploitation.

assistant: **Impact**

Obesity is the fasted growing health problem in the Western World. In the United States, obesity as cause of preventable mortality (365,000 deaths in the year 2000) will soon overtake tobacco (435,000 deaths) and already has overtaken alcohol consumption (85,000 deaths), infectious diseases (75,000) and motor vehicle crashes (43,000). More important, it is also a problem in children and adolescent, and accordingly, one of the major future health problems. We hypothesize that the reduction of hormones/signals, released or blocked after food intake as nutrition signal, significantly contributes to the feed-back in food intake, and subsequently to the onset in obesity. Accordingly, the focus of this project is the understanding of the contribution of gastro-intestinal peptides to the onset of obesity. It is aimed to identify the most relevant hormones or combinations of hormones, and subsequently to develop anti-obesity drugs that are based on endogenous hormone agonists or antagonists. The project will include the following aspects and competences: Production of endogenous hormones by synthetic approaches according to the guidelines of GMP and investigation in human volunteers by fMRT. Most promising candidates will be studied in more detail. This will include ghrelin, orexin, GLP, PP and PYY. Experiments will occur on the molecular, cellular and animal level. Original and optimised hormones will be modified with DOTA and used for labelling, and subsequent analysis in PET studies to allow the follow up of distribution and stability. In a medicinal chemistry concept, non peptidic drugs and peptide mimetics will be further explored for PYY and PP first as well as for ghrelin, orexin and GLP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DATACULTURE: Deconstructing the Cultural Narratives Shaping the Politics of Datafied Governance in Urban Planning' in the context of a Horizon Europe call.

assistant: **Objectives**

The DataCulture (DC) project investigates the cultural politics of digital planning technologies in Denmark's urban governance, addressing how these tools operate beyond neutral technical functions to embed specific imaginaries of innovation, efficiency, and objectivity. Through an interdisciplinary methodology combining interface analysis, infrastructure ethnography, participatory workshops, and policy analysis, the project reveals how algorithmic planning systems embed social biases, depoliticise spatial conflicts, and transform democratic deliberation into technical optimisation. The research advances three core objectives: theoretically, it exposes symbolic power and cultural narratives legitimising algorithmic governance; methodologically, it develops bias-auditing protocols and research-creation approaches to analyse infrastructure materiality; and for policy impact, it demonstrates how these systems contribute to post-political urbanism while providing frameworks for more accountable digital governance. Building on established work in critical data studies and urban theory, the project extends analysis to encompass generative AI and automated decision-making impacts on spatial planning. The project's distinctive contribution lies in the systematic examination of symbolic power, cultural narratives and algorithmic governance of digital planning platforms through both the data they produce and the imaginaries they mobilise. The project's public installations and participatory methods ensure broader civic engagement, making this research valuable for designers, planners, and citizens navigating the datafied city as well as for scholars, policymakers, and practitioners working at the intersection of technology, culture, and urban planning.


**Keywords:** Critical Da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reinforcement-related behaviour in normal brain function and psychopathology' under Sixth Framework.

assistant: **Concept**

A fundamental function of the brain is to evaluate motivational and emotional significance of stimuli and to adapt behaviour accordingly. We hypothesize that genetically influenced individual differences in brain responses to reward, punishment and emotional cues in adolescents mediate risk for mental disorders with a major public health impact. Neuroimaging permits the measurement of specific brain functions implicated in the etiology of mental disorders and link them to genetic variations and behavioural characteristics relevant to disease processes. The goal of the present study is to identify the neurobiological and genetic basis of these traits and to assess their relevance for mental disorder. To this end, we will perform the first multicentre functional and structural genetic-neuroimaging study of a cohort of 2000+ 14 year old adolescents. Intermediate phenotypes of risk for adolescent mental illness will be explored based on cognitive, behavioural, clinical and neuroimaging data. To determine the predictive value of intermediate phenotypes and genetics for development of mental disorders, our cohort will be psychometrically assessed during recruitment and longitudinally at year 4 (age 16-18) of this proposal. DNA samples and phenotype database for the cohort will create a powerful resource for present and future genetic investigations. In the present study, we will assess association with markers of genes chosen from existing genomic information and from our studies of animals selected for extreme phenotypes of impulsivity and other relevant behavioural traits. Results obtained will be validated in 1000 siblings from the Canadian Saguenay youth neuroimaging study. The IMAGEN study will help elucidate the neural basis of mental disorders and will lay the groundwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Democratic participation in urban governance' (DEMOS) under Fifth Framework.

assistant: **Objectives**

The DEMOS project will address the need for innovation and sustainability in urban governance in a European society suffering increasingly from democratic deficit, citizen dissatisfaction and policy fragmentation. Project partners form 3 interlinked spheres of action research: city test sites, research & evaluation framework, and advisory & dissemination forum. Core partner cities will implement & test innovatory mechanisms for participatory local governance, using an Innovation Development Fund. Research partners will continuously assess & feed back on the partner cities' organisational processes and outcomes & provide them with training. Associate partners will contribute to the project's audit of existing good practice & the pool of ideas for innovative actions to be piloted. All core, research & associate partners, jointly with a wider network of interested authorities, will disseminate the transferable project results, aiming to build the findings into integrated policy-making.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing a Pilot Case aimed at establishing a European infrastructure project for CO2 transport' (GATEWAY) targeting Horizon 2020.

assistant: **Abstract**

The OBJECTIVES of this proposal are as followsa) to define a subsequent initiative, referred to as the Pilot Case, providing a model for establishing a European CO2 infrastructure project, targeting a gateway transferring CO2 from source to sink. The gateway will form the first leg of a cross-border network, allowing multiple sources and multiple sinks.b) to make profound assessments of the substantial funding needs and available resources. c) to solicit strong actions by the partners involved (member states of the EU and other countries) with a three-step approach (Berlin model). The objectives will be ACHIEVED by acquiring commercial and legal input from various sources, such as industries, research alliances and institutes, investors and funding agencies, and engage industries capable of providing the knowledge of how to initiate the first gateway(s) of a future European CO2 transport system. This will include - knowledge gathering, involving structured intelligence processes, - outline strategies, - assessment of lead times, - scenario building, - consideration of funding synchronization issues. - assessing the economic potential(s), timing, and organisation towards the deployment of CCS within Europe, and gradually increase the deployment so that it applies to Europe as a whole, thus providing a Pan-European infrastructure for CO2 transport, - the initiation of a strict planning of the infrastructure, including the handling of specific policy issues and regulatory requirements. These objectives demonstrate a clear RELEVANCE to the H2020 Work Programme, calling for proposals for a pilot case addressing areas and challenges targeted in the competitive low-carbon energy call. This proposal pursues activities that support 'the use of research outcomes by industry of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Nano-technology enabled repositioning of Disulfiram as an anti-cancer stem cell agent'.

assistant: **Concept**

Most cancers remain ‘incurable’ and life-thretening. Cancer stem cells (CSCs) are the source of chemo/radioresistance and responsible for cancer recurrence which suggests the urgent requirement of CSC-targeting drugs. Drug development is a slow (15 years/drug) and costly (US$1.5bn/drug) procedure with only 5-25% of new oncology drugs in clinical development actually reaching the market mainly due to the toxicity of novel molecules. This dilemma has led to an increasing appreciation of the potential of repurposing of known drugs. We have demonstrated that Disulfiram (DS), an old anti-alcoholism drug, possesses excellent anti-CSC activity with low toxicity to normal cells. Whereas its cancer clinial indication is limited by its bio-instability (~4 min half-life in blood stream). Our pilot data demonstrated that the anticancer efficacy of DS is significantly improved when mild extending its half-life by liposome encapsulation. In this study, the Incoming Fellow, who has very strong technical knowhow in cancer research, molecular pharmacology, anticancer drug development and nano-encapsulation, will bring novel nano-biomaterials invented in China into Europe. Taking advantage of the state-of-the-art facilities, CSC models, pharmaceutical resarch and developmental expertise and scientific/technical support from the Incoming Host and the other European collaborators, we will develop a long-circulating nano-encapsulated DS. The anticancer activity of the nano-encapsulated DS will be examined in vitro and in vivo in breast and liver cancer cell lines as well as the relevant CSC models. This study will pave the path for clinical trial of DS in cancer indication. The significance of this project will be: 1. Expand and extend our FP7-IRSES (2011-16) platform to strenthen long-term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of p16INK4a in the development of obesity and insulin resistance' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Genome-wide association studies have linked the CDKN2A locus to an increased risk of Type 2 Diabetes (T2D), which is mostly accompanied by insulin resistance (IR) and obesity. The CDKN2A locus encodes p16INK4a, a tumor suppressor. p16INK4a is an inhibitor of cyclin-dependent kinases, which regulate the cell cycle. Recent studies have shown a link between p16INK4a and the control of inflammation. T2D is an inflammatory disease, in which macrophages are important effector cells. Moreover, adipose tissue macrophages (ATMs) have been found necessary and sufficient for IR to develop. Resident ATMs are known to display an anti-inflammatory “M2” phenotype. Upon obesity, a switch towards a pro-inflammatory “M1” phenotype has been described, inducing adipocyte dysfunction and systemic IR. Additionally, recent findings from the host laboratory indicate that macrophages lacking p16INK4a exhibit a M2 phenotype. Therefore, we hypothesize that p16INK4a may play a role in the development of IR and obesity, possibly by influencing macrophage polarization. To study the role of macrophage p16INK4a in obesity and IR, we will perform a series of bone marrow transplantation experiments, creating mice that lack p16INK4a immune cells (like ATMs) but not in other cells of the body. Several metabolic parameters, like insulin and glucose tolerance, will be analyzed in vivo. Tissues of these animals will be examined thoroughly on mRNA and protein level. The molecular mechanisms of p16INK4a action on macrophage polarization will be further investigated with microarray analysis of isolated ATMs. In addition, the effects of p16INK4a deficient macrophages on adipocytes will be determined in vitro via direct and indirect co-culture experiments. Finally, using this experimental setup of co-culture, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bi-directional Force Communication on Cell-Matrix' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NESCIO: NEtherlands Science Conference on Inclusive Open science'.

assistant: **Innovation**

The Project is a two-day Open Science Presidency Conference, which is to be held on 4-5 April 2016 and organised in the Netherlands. Its core theme is ‘Open Science: from Vision to Action’. On day one, the focus will be on:1.Creating Awareness for the need to make a transition towards an open science system.2.Raising Political Support for Open Science, the Open Science Agenda and the start of the EC Open Science Policy Platform. On day two, the focus will be on: 3.Presenting a European Action Agenda on Open ScienceThe key objective of this Conference is to bring together stakeholders (universities incl. libraries, researchers, funding organisations, publishers) and member states and EC to agree upon a joint perspective and view on realizing open access to scholarly publications by 2020 and to set up a platforms and infrastructure to make optimal (re-)use of research data possible.  At the conference there will be the announcement of an Open Science Policy Platform (by EC) and an Action Agenda on Open Science (with focus on open access and open data) that addresses short/medium/long term goals for stakeholders, member states and European Commission.-Science is about curiosity, understanding, discoveries, new knowledge and maximum transfer of knowledge, not only within science but also to transfer knowledge to society and innovative businesses. -We should invest in science and increase its returns (which is more than going for maximum impact factor scores in a ‘publish or perish’ culture), because research is at the basis of innovation, growth and welfare. The results of the Conference will be used as input for the Council Conclusions of the Competitiveness Council in May 2016, and as input for the Open Science Policy Platform. These Conclusions will be the start of conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intergenerational Mobility, Inequality, and Entrepreneurship along the Path of Development', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

A society where individuals can pursue their dreams, striving to become whatever they desire, excels both in efficiency and equity. However, throughout history, following parents' occupations was the norm, changing social class an exception. The question remains: what caused the increase in social mobility? My research program aims to answer these questions with three interconnected projects. Project I tackles the main obstacle to studying mobility: the availability of long-run individual-level panel data of parents and children. Digitizing an overlooked series of historical books, I will build a unique dataset of incomes and occupations of the universe of Swedish taxpayers since 1905, matched with panel data of firms with their revenue, payroll, and top executives since 1857. The novelty lies in the universal coverage of data, spanning the birth of prosperous, innovative, and inclusive Sweden with an advanced welfare state.Project II leverages this comprehensive dataset to establish stylized facts about mobility in labor and capital incomes, as well as in occupation and entrepreneurship. They will shed light on the long-run patterns of mobility and its associations with inequality and growth, resolve long-standing controversies, and bring new insights into the debate. Project III develops a novel theoretical model of mobility that uncovers the drivers of mobility. The model shows that social mobility is driven by the tension between opportunities for social climbers to access physical and human capital and the privileges of the elite to hinder such access. We exploit quasi-experimental evidence to test this theory, using the expansion of private banks and public education, as well as the rise and fall of progressive taxation. Together, the projects build micro-founded