RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interactive web-based tool for the design of multi-RNA binding protein binding site cassettes' to be submitted under Horizon 2020.

assistant: **Abstract**

DNA synthesis technology has greatly developed over recent years, serving a growing multi-billion synthetic DNA market. Synthetic DNA is used in projects that optimize reagents, chemicals, crops and other organisms, in projects seeking to increase the manufacturing efficiency for the above, as well as in studies of molecular regulation and other cellular processes. The latter is the focus of the MRG-GRammar H2020 FET project.As the market and application range for synthetic DNA expand a need arises to test and quality control raw synthetic nucleic acids as well as products built upon such reagents. We have developed a prototype software tool for assessing quality parameters in synthetic DNA libraries and used it in several projects in the framework of MRG-GRammarWe propose to productize this prototype into a stable version that will be availed to a broader synthetic biology community. Our proposed product, CARBP, is a software system that enables design of RNA binding protein binding sites cassettes for various applications in biological imaging and synthetic biology. Requested funding will be used to improve usability and user interface, to expand the implementation of analysis and statistical tools, to produce a stable version available to the scientific community and to commercial entities and, finally, to investigate potential sustainable mechanisms for supporting continued service, including commercial or service models. CARBP will form part of a suite of interactive web-based tools whose purpose will be to accelerate the development of the nascent synthetic biology industry sector, by making advanced molecular technologies available to various users at a push of a button.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'VertIcal demos over Common large scale field Trials fOr Rail, energy and media Industries' in the context of a Horizon 2020 call.

assistant: **Objectives**

5G solutions for verticals is a well-defined European objective. This requires developing 5G infrastructures to address a wide range of applications adopting flexible architectures, offering converged services across heterogeneous technology domains with unified software control. However, vertical industries today can only verify use cases in small scales in commercial environments, before investing in large scale deployments. Through ICT-17 projects 5G infrastructures become available to verticals to test their applications, however large-scale trials are still not possible. 5G-VICTORI will conduct large scale trials for advanced vertical use case verification focusing on Transportation, Energy, Media and Factories of the Future and cross-vertical use cases. It leverages 5G network technologies developed in 5G-PPP Phase-1 and Phase-2 projects 5G-XHaul and 5G-PICTURE and exploits extensively existing facilities interconnecting main sites of all ICT-17 infrastructures i.e. 5G-VINNI, 5GENESIS and 5G-EVE and the 5G UK test-bed in a Pan-European Infrastructure. The project will provide enhancements of existing infrastructures towards integration of a large variety of vertical and cross-vertical use cases. 5G-VICTORI’s platform aims to transform current closed, purposely developed and dedicated infrastructures into open environments where resources and functions are exposed to ICT and vertical industries through common vertical and non-vertical specific repositories. These functions can be accessed shared on demand and deployed to compose very diverse set of services in a large variety of ecosystems. 5G-VICTORI’s uniquely strong consortium brings together major players form ICT including operators, equipment vendors academic and research organisation and SMEs as well as main
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Stable and Efficient Alkaline Water Electrolyzers With Zero Critical Raw Materials for Pure Hydrogen Production'.

assistant: **Innovation**

The EU Hydrogen Strategy sets the goal of installing at least 40 GW of renewable H2 electrolysers by 2030, which imposes significant challenges for water-electrolysis technology. Although current zero-gap alkaline water electrolysis (AWE) has potential for cost-effectiveness and scalability, it needs further optimization in activity, stability, and gas crossover to increase efficiency and system lifetime.This project will develop a new class of AWE combining proven benefits of classic systems with cutting-edge innovations in materials science, catalyst design, and process engineering. Driven by an industrial-feasibility vision, a system that is both technically advanced and economically viable for large-scale commercial deployment is pursued. The proposed innovations include highly efficient and earth-abundant two-dimensional layered double hydroxides (LDH) obtained through a starightforward synthetic route, offering a sustainable and cost-effective alternative to noble metal-based catalysts. An innovative technology for up-scaling the production of LDH layers by direct growth of catalysts in porous transport electrodes will be implemented and explored on commercial separators. The interplay between the substrate, catalyst, and separator will be thoroughly optimized through the development of triple-phase boundary electrodes (catalyst-support-ionomer) structures with improved thermo-mechanical stability. A reliable method based on Raman spectroscopy, will be developed for the precise determination of electrode stability, offering an appropriate quality control of great interest both in research and industry. The optimal design will be assembled and tested, first in single cells of 5 cm², then in 25 cm², and finally scaled to a 6-cell stack of 300 cm², to demonstrate a n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new avenue in the hunt for dark energy'.

assistant: **Concept**

Currently, General Relativity (GR) and the standard model of particles physics are severely challenged by their inability to explain the late-time accelerated expansion of the Universe, known as the “dark energy” problem. The most promising scenarios aiming to explain it are the so--called scalar-tensor theories, corresponding to extensions of GR where gravity is enhanced through a new gravitational force mediated by a scalar field. The quest for phenomenological imprints of new scalar gravitational forces has been a central effort in cosmology and astrophysics over the last decade.My goal is to introduce helioseismology as a test of unprecedented accuracy in the search for new gravitational forces in Nature. The focus will be on the most general scalar-field extensions of GR, known as “DHOST” scalar-tensor theories. The unique ability of solar pulsations to probe the finest details of gravity in the solar interior, combined with the extreme accuracy of helioseismic observations, promises an orders-of-magnitude improvement of previous constraints.I will formulate the theoretical framework for adiabatic stellar pulsations in this context, and with sophisticated numerical techniques, I will model the associated solar pulsation eigenspectrum. A systematic statistical analysis will be devised to confront the predictions against observations making use of powerful helioseismic inversions, and derive the tightest constraints on the most general scalar-tensor theories up to date. The cosmological implications will be predicted, in accordance with ESA’s upcoming Euclid satellite mission.The project will introduce a genuinely novel, interdisciplinary line of research that will strongly impact a broad spectrum of cosmology and astrophysics. The new constraints will be pivotal for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Accident and emergency implementation of distributed riche architecture'.

assistant: **Innovation**

The partners within AIDA have built upon work already completed in a number of EC supported RTD projects to demonstrate the feasibility of a RICHE implementation in a way which will clearly show the benefits to hospitals of moving towards Patient Centred, Hospital Information and Support Systems (HISS) for the support of health care professionals and hospital management.The implementation, in an Accident and Emergency (A&E) unit, demonstrates the usefulness of the RICHE approach in a key hospital department which must function frequently under circumstances of high pressure and throughput. AIDA aims to demonstrate that the technologies developed in these RTD projects are a sound basis for the development of major integrated hospital systems.AIDA has provided the participating organisations with an operational installation which can be used to demonstrate the benefits to be obtained from implementation of the combined results of a number of RTD projects.We intend to implement a new Accident and Emergency process support system that is RICHE conformant. The system integrates several existing IT systems within the hospital and provide a single comprehensive application for users within the A&E department. Major benefits of the new system include faster patient assessment and throughput with less administration overhead, the system also provides access to most aspects of patient clinical information.The use of an open, distributed architecture for the implementation of such a health care application is quite new; whilst designs and prototypes have existed and been experimented with for some time, this is an early implementation of an operational system based upon RICHE technology.In a RICHE system a layer of common services exists, called the Distributed Hospital Environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards Industrial LES/DNS in Aeronautics – Paving the Way for Future Accurate CFD' (TILDA) under Horizon 2020.

assistant: **Objectives**

The ability to simulate aerodynamic flows using CFD methods has progressed rapidly over the last decades and has given rise to a change in design processes in aeronautics already. But more improvement is necessary to overcome the (still) existing lack in confidence in CFD usage, based on turbulence modelling. The TILDA project will offer methods and approaches combining advanced and efficient high-order numerical schemes (HOMs) with innovative approaches for LES and DNS in order to resolve all relevant flow features on tens of thousands of processors in order to get close to a full LES/DNS solution for 1billion degrees-of-freedom (DOF) not exceeding turn-around times of a few days. The TILDA project will provide both an improved physical knowledge and more accurate predictions of non-linear, unsteady flows – near borders of the flight envelope - which will directly contribute to an enhanced reliability. The main highly innovative objectives, targeting at industrial needs read: • Advance methods to accelerate HOM for unsteady turbulence simulations on unstructured grids. • Advance methods to accelerate LES and future DNS methodology by multilevel, adaptive, fractal and similar approaches on unstructured grids.• Use existent large scale HPC networks to enable industrial applications of LES/DNS close(r) to daily practice. Compact high-order methods offer a very high ratio between computational work per DOF combined to a low data dependency stencil, making these methods extremely well adapted for shared-memory parallel processors, and allow for efficient redistribution over an increased number of processors.• Provide grid generation methods for HOM on unstructured grids with emphasis on valid curvilinear meshes for complex geometries, and accounting for mesh and solution qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Responsive Flexible Collaborating Ambient'.

assistant: **Concept**

We are currently standing on the brink of a new era of computing systems: Moving on from desktop computers, computing intelligence will be woven into the fabric of everyday life", seamlessly and near-invisibly pervading our environment, sensing our presence, mood, and intentions, thus delivering services adapted to ourselves and our context of use.<br/><br/>The REFLECT project aims at developing new concepts and means for such "pervasive-adaptive systems". To begin with, REFLECT researches ways of sensing users and their mood and intentions. Different aspects are taken into account: emotional state (e.g. annoyance), cognitive engagement (e.g. high mental workload) and physical conditions and actions (e.g. temperature and movement). All these together with human behavioural patterns form the personal awareness of the system. Additionally, information about the surroundings is gathered and used to establish environmental awareness.<br/><br/>Augmenting these results, REFLECT investigates ways of realizing pervasive-adaptive environments. A software framework with a set of practical tools is developed which can be used for building pervasive, adaptable, self-organized systems that seamlessly collaborate with users and control their environments. <br/><br/>The resulting REFLECT system will be able to derive, suggest and perform actions to optimize user comfort and performance, assisting people in their specific activities (for example, in driving a vehicle). To illustrate the pragmatic orientation and results, the REFLECT project includes a number of case studies and a prototype from the automotive domain that shows how such systems can be deployed in practice.<br/>"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ROBOT FLEETS FOR HIGHLY EFFECTIVE AGRICULTURE AND FORESTRY MANAGEMENT' in the context of a Seventh Framework call.

assistant: **Objectives**

In the last two decades, a precise management of agricultural land has been made possible due to the availability of new technologies, including global positioning systems (GPS), geographic information systems (GIS), sensors, automation of agricultural machinery, and high resolution image sensing. As a result, the concept of Precision Agriculture has emerged as the management strategy that uses information technologies to collect and process data from multiple sources in order to facilitate decisions associated with crop production. Moreover, the EU’s sixth environmental action programme  addresses the need to encourage farmers to change their use of plant protection products’ .RHEA is focused on the design, development, and testing of a new generation of automatic and robotic systems for both chemical and physical –mechanical and thermal– effective weed management focused on both agriculture and forestry, and covering a large variety of European products including agriculture wide row crops (processing tomato, maize, strawberry, sunflower and cotton), close row crops (winter wheat and winter barley) and forestry woody perennials (walnut trees, almond trees, olive groves and multipurpose open woodland).RHEA aims at diminishing the use of agricultural chemical inputs in a 75%, improving crop quality, health and safety for humans, and reducing production costs by means of sustainable crop management using a fleet of small, heterogeneous robots –ground and aerial– equipped with advanced sensors, enhanced end-effectors and improved decision control algorithms. RHEA can be considered as a cooperative robotic system, falling within an emerging area of research and technology with a large number of applications as reported by the FP6 Network of Excellence EURON, Special Intere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Urban river basin enhancement methods' under Fifth Framework.

assistant: **Concept**

Urbanisation, and modification, of watercourses commonly causes severe degradation. Improving the water quality, ecology, aesthetics, amenity and social value of urban watercourses will increase the sustainability of European cities. The objectives of URBEM are to: develop tools to assess the potential for rehabilitation of urban watercourses; research urban specific rehabilitation technique; provide decision-making support methodologies to let urban authorities undertake rehabilitation. These objectives will be achieved by monitoring and information gathering at urban watercourse study sites across Europe. The results of URBEM will give an understanding of urban watercourses, and allow more rehabilitation projects to be facilitated. A multi-disciplinary team of researchers, consultants and urban authorities will undertake the work, and allow extensive dissemination of the project results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum Photonics in Space and Time' in the context of a Horizon Europe call.

assistant: **Objectives**

The realization of complex quantum networks that efficiently distribute entanglement over large-scale distances remains a central challenge in quantum technologies, while offering the potential for breakthrough next-generation applications. Entanglement-based quantum communication can provide the ultimate form of security that is independent of any devices used, distributed quantum computing protocols promise a scalable approach to fault-tolerant quantum computing that will revolutionize information processing, and distributed quantum sensing schemes enable sensor networks to reach the ultimate limits of sensitivity. While entanglement lies at the heart of these exciting technologies, its efficient generation, noise-robust distribution, and practical measurement are key challenges that must be overcome for the realization of a real-world quantum network infrastructure. QUEST will harness the multi-modal properties of light in space and time to target specific technology bottlenecks that limit the scalability of quantum networks today. QUEST will develop a versatile device that performs programmable transformations of spatially structured quantum light and use it to address key challenges in entanglement generation, distribution, and measurement. QUEST will engineer deterministic sources of multipartite and high-dimensional entanglement and develop methods for the generalized measurement and manipulation of high-dimensional entanglement encoded in the photonic spatiotemporal degrees-of-freedom. QUEST will in turn apply these technologies in quantum protocols that achieve noise and loss-robust distribution of the strongest forms of entanglement over deployed fiber networks spanning multiple distance scales. In doing so, QUEST will open a pathway towards scalable and relia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '2shRNA branched nanobinders as promising therapeutic tools for combined cancer therapy' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project aims to optimize and validate a promising therapeutic tool for combined cancer therapy, 2shRNA, in an ex vivo model system.Combined therapies are of great significance nowadays, due to their key role in fighting, for instances, resistance processes during cancer treatment. Nonetheless, the drug combinations approved to date face several problems, such as cooperative toxicity effects, lack of efficiency and poor bioavailability. We have designed and synthesized 2shRNA, a new bifunctional RNA tool that can simultaneously attack two therapeutic targets involved in drug resistance pathways, and that can additionally bind other molecules such as peptide carriers or fluorophores, to improve delivery and efficacy. The 2shRNA nanostructure displayed low toxicity and excellent anti-proliferative properties in resistant HER2+ breast cancer cell lines. The present proposal is aimed at optimizing and validating this novel and promising RNA tool by combining state-of-the-art bioinformatics design and cycles of chemical refinement with biological evaluation in PDx-derived primary cell cultures and biodistribution studies in PDx mouse models. The proposed strategy presents a novel therapeutic approach with great potential to circumvent drug resistance in breast cancer, which is a major health challenge for our society. The ability of our biostable RNA tool to administer two drugs in a single dose could improve the quality of life of the patients, as fewer doses might be needed to stall disease progression.