RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SPatial Analysis of Cancer Evolution in the Tumour Immune MicroEnvironment' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The introduction of immune checkpoint therapy for Non-Small Cell Lung Cancer (NSCLC) has improved clinical outcomes. However, due to primary or secondary resistance, only a minority of patients show long term responses, leading to exploration of a multiplicity of new agents and combinatorial strategies. Due to lack of biomarkers that can predict response, many patients are submitted to treatments that will not have clinical benefit. A thorough understanding of the biological processes causing resistance to immunotherapy in NSCLC could facilitate informed personalised therapy choices. This requires a multifactorial assessment of the tumour microenvironment, a complex and dynamic milieu, encompassing the majority of tumour-host interactions. SPACETIME brings together interdisciplinary expertise to achieve a superior understanding of the spatial and temporal tumour-host co-evolution, and drive translation into predictive biomarkers for precision immunotherapy. We will integrate spatial proteomics, transcriptomics, metabolomics and glycomics to analyse patient biopsies from early stage to metastatic disease, complemented with tissues from representative mouse models to cover the developments early after tumour initiation. Environmental and systemic factors that may influence this co-evolutionary process will be included to identify potential risk factors for therapy resistance. Ex-vivo, in vitro and in vivo assays will bring functional understanding of immune resistance mechanisms and identify key cellular interactions and therapeutic targets. This will be brought together by advanced computational approaches, to define spatial signatures, that will lead to a limited panel of potential prognostic and/or predictive markers for immunotherapy. Supported by engagement of key st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Multiple sensor fault tolerant control for management of interconnected, nonlinear systems'.

assistant: **Concept**

This project deals with the problem of fault tolerant control (FTC) for the management of interconnected, nonlinear systems affected by multiple sensor faults. Sensor faults are of paramount importance due to the large number of sensors used for a) monitoring and control of large-scale systems (e.g. transportation systems, energy and power systems), and b) providing rich and redundant information for executing safety-critical tasks (e.g. aerospace systems, petrochemical processes). The number of sensors is expected to increase in the way of creating smart cities, a societal challenge of European Union. To this end, Europe 2020 strategy has set as key priority the enrichment of digital society that will provide `intelligence’ to a conventional city, using information and communication technologies integrated with sensors and sensor networks. This project proposes a methodology that can contribute in the reliability of these means, the safe system functioning and the protection of everyday life. The novelty of the proposed FTC method lies in its capacity to handle multiple sensor faults, and furthermore to compensate their effects on interconnected, nonlinear systems. This is realized by deploying a large number of agents in a non-centralized architecture, important for FTC in large-scale systems. The FTC is conducted based on the decision of a multiple fault diagnosis (MSFD) mechanism designed to detect and isolate multiple sensor faults in interconnected, multisensory controlled systems. Given that multiple sensor FTC can be significantly affected by the substandard performance of the MSFD mechanism and the network imperfections of the agent’s communication, derived methods will be supported by MSFD guarantees and communication protocol will be designed to manage commun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A tangled web: Foxp2 and language related neural networks' (2007-2013) under Seventh Framework.

assistant: **Objectives**

FOXP2 was the first gene directly implicated in language development and mutations cause rare but severe forms of language disorder. FOXP2 encodes a protein that acts as a transcription factor, regulating the expression of other genes. Our previous work used FOXP2 as an entrypoint to define molecular networks associated with language, and showed that Foxp2 contributes to neurite outgrowth in the developing brain. Furthermore, mouse models suggest that Foxp2 may be acting in language related areas of the brain to affect connectivity and plasticity. Here, we aim to understand fundamental aspects of neural network formation and neuronal activity controlled by Foxp2. We will use a model system (the mouse brain) to investigate how neuronal network connectivity develops in language related brain areas. We will also manipulate levels of Foxp2 and its previously identified target genes to understand how these genes contribute to network formation. We will define the upstream regions and factors that regulate Foxp2 expression to better understand the wider molecular networks associated with language development. We predict that FOXP2 expressing neurons are related to language circuitry and thus we will use the enhancer regions that we identify to generate mouse lines that will mark out specific sub-populations of Foxp2 positive neurons in the developing brain, to shed light on the connections they form. Lastly, we will use these enhancer regions to create mouse lines that allow us to observe the activation of Foxp2 positive neurons and the role of these circuits during behavioural tasks. Taken together, this work will help us to understand the formation and activity of language related neural networks, and shed light on underlying cellular and network defects that may be associa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart Adaptive Remote Diagnostic Antitampering Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Emissions standards for vehicles have managed to introduce state-of-the art emissions controls that have brought significant reductions in the actual emissions levels. However, there is increasing clear evidence of illegal manipulation of emission control systems by vehicle owners and widespread usage is observed in the market. In general it is almost always the vehicle’s owner or operator that tampers the EPS for economic advantages; either to reduce fuel or urea costs, or to avoid costly repairs of aged or malfunctioning equipment. Traditional OBD systems are designed to inform users about malfunctions of systems and components and notify the users of the repair needs and cannot prevent tampering. The primary target of DIAS is thus to harden vehicle environmental protection systems (EPS) against such tampering. This means that any changes in EPS hardware, software that degrade the performance of the system will be prevented, or detected. DIAS will develop innovative protection and security measures to increase the level of prevention. In case detected, information about the tampering attempt is available and is used to introduce countermeasures e.g. the activation of the driver inducement systems. DIAS brings together a highly qualified interdisciplinary team that starts with OBD and takes a two-step approach that involves implementing first measures to take early action against these activities, and a second cloud-based step that prepares methodologies and means for dealing with tampering attempts in the future that are currently unknown. Additionally DIAS will take into account that effective upcoming new tampering countermeasures can also be applied on vehicles already in the field to have an even stronger impact on preventing unnecessary environmental pollution. F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chemical rewiring of E3 ubiquitin ligases as a generalizable therapeutic approach' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Classical drug design relies mostly on the availability of accessible pockets to block specific protein activities. Despite tremendous progress, more than 80% of all human proteins remain beyond the reach of traditional inhibitor-centric approaches. Chemical ablation of protein abundance using bivalent degraders (PROTACs) moves away from an occupancy-driven (inhibition) to an event-driven (binding) pharmacology. However, their design is intrinsically limited to targets that are ligandable via chemical probes. To tackle current unmet clinical problems, we need transformative paradigms.Fortuitous discoveries have illustrated the immense potential of monovalent degraders. These molecules induce the degradation of target proteins by molecular gluing to E3 ubiquitin ligases or by prompting their destabilization. They have desirable drug-like properties, proven capacity to induce the degradation of proteins otherwise deemed undruggable, and they are already a clinical reality. However, their discovery has been driven by serendipity, thereby hampering their realization as a generalizable drug solution.TrickE3 seeks to establish the foundations for the systematic development of monovalent degraders. To this end, we will develop innovative methodologies to detect and predict drug-induced changes in the interactome/activity of E3s at scale. As proof of principle, we will focus on the chemical rewiring of E3s expressed in pancreatic ductal adenocarcinoma (PDAC) due to the imperative need for treatments. We intend to prospectively identify monovalent degraders (i) of specific vulnerabilities, and (ii) to unlock new PDAC targets.At the interface of chemical biology and cancer research, TrickE3 will be an instrumental resource to broaden drug discovery efforts, probe disease-relevant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Understanding unconventional superconductivity in twisted flatlands'.

assistant: **Objectives**

It is widely believed that the development of room temperature superconductivity is one of biggest challenges of modern physics and will lead to a technological revolution. However, a detailed understanding of how high temperature superconductivity arises in unconventional superconductors has to this day eluded scientists. This year, in a breakthrough discovery, scientists have found superconductivity in a radically new compound, which has a strikingly similar phenomenology to most unconventional superconductors – “magic” angle bilayer graphene. As graphene crystals are ultra-clean, highly tuneable and its parent state is well understood, I strongly believe that the study of these compounds will cause a long awaited revolution in the comprehension of unconventional superconductivity.In this project I will uncover the nature of superconductivity in “magic” angle graphene, by experimentally revealing its defining aspect – the superconducting order parameter. While no experimental method alone can definitely define the order parameter and since key experimental techniques are unavailable for these truly nano-scale materials, I will implement a radically new, multidisciplinary approach between material science and the development of disruptive measurement techniques. To achieve this ambitious goal, my truly unique background is essential, which includes van der Waals engineering, quantum transport, microwave engineering and quantum optics. I will employ these versatile skills to (i) develop robust procedures to engineer novel van der Waals hetero-structures of “magic” angle graphene to manipulate its phonons, impurities and magnetic correlations, (ii) perform Josephson interferometry and tunnelling experiments toinvestigate its macroscopic phase, spin state and excitation s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of excellence in non-invasive diagnostic systems for industrials and scientific applications' to be submitted under Sixth Framework.

assistant: **Abstract**

The present project, called DENIDIA, foresees for the Department of Computer Engineering of the Technical University of Lodz, Poland, to reach in the next three years excellence in non-invasive diagnostic systems for industrial and research applications. The non-invasive techniques considered in this ToK are based on the tomography technology. The host institution has been acquiring a lot of knowledge in terms of data acquisition, reconstruction, and visualisation of Electrical Capacitance Tomography, a system particularly well adapted for real time industrial process measurements like multi-phase flow in pneumatic conveying.The Department of Lodz will carry on technological and programming research on ECT to develop systems with a higher resolution and three- dimensional acquisitions, without losing the main advantage of fast data acquisition. The host institution has also the goal to widen its computing knowledge in terms of software development to visualise, process and analyse data from different fields of applications acquired from different tomography set-ups. The Department believes that these objectives will be achieved by acquiring more scientific knowledge from other fields of research which use non invasive techniques (i.e. chemical engineering, materials science, medical science), and by widening its expertise to technological and programming knowledge from other systems like Optical, gamma-ray, X-ray and dual modality tomography techniques.The project proposes, for a global cost of around 945000 euros, the recruitment/secondment of experienced researchers, and staff training in 5 partner institutions from France, UK, Norway and Malaysia, which all respond to the need of the proposal. A ToK-dev scheme is the most appropriate action which can enable the objec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Neutralizing antibodies against botulinum toxins A,B,E'.

assistant: **Concept**

Botulinum neurotoxins (BoNTs), the most toxic substances known, are susceptible for use as bioweapons (listed as class A agents by CDC). Currently licensed animal derived antibodies or F(ab’)2 preparations, are at a high risk of inducing adverse effects and their privately-owned stockpiles are limited. In this project, we will target the most lethal types of BoNTs: A (subtypes A1 and A2), B (B1 and B2) and E (E1). The antibodies will be directed against the C-terminus of the heavy chain and the light chain of each of these three BoNTs, as these domains contain neutralizing epitopes, according to the latest scientific data. The six corresponding immunogens will be produced in recombinant form, and utilized to immunize macaques (Macaca fascicularis), from which phage-displayed immune libraries will be built. Utilizing the phage technology, scFvs cross- reacting with A1 and A2, or B1 and B2subtypes will be panned. The best scFv from each library will be selected according to its high affinity and in vitro neutralization property. The six most neutralizing scFvs will then be super-humanized (“germline-humanized”) and expressed as IgGs, which will be tested in vivo, in a standardised model of protection and against toxins obtained from collections of clostridia strains. The project includes representatives of medical first-responders who will disseminate our results, and help create a market so that the necessary clinical studies could be performed in future. The project will offer an unequalled level of security against biothreats in Europe, based upon a family of well-tolerated and effective molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European project for standardized transparent representations in order to extend legal accessibility' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The primary business objective of the Estrella project is to develop and validate an open, standards-based platform allowing public administrations to develop and deploy comprehensive legal knowledge management solutions, without becoming dependent on proprietary products of particular vendors.Estrella will support, in an integrated way, both legal document management and legal knowledge-based systems, to provide a complete solution for improving the quality and efficiency of the determinative processes of public administration requiring the application of complex legislation and other legal sources. Estrella will facilitate a market of interoperable components for legal knowledge-based systems, allowing public administrations and other users to freely choose among competing development environments, inference engines, and other tools.The main technical objectives of the Estrella project are to develop a Legal Knowledge Interchange Format (LKIF), building upon emerging XML-based standards of the Semantic Web, including RDF and OWL, and Application Programmer Interfaces (APIs) for interacting with legal knowledge-based systems. To achieve and demonstrate vendor neutrality and independence, translators between the LKIF format and the existing proprietary formats of LKBS vendors participating in the project will be developed.To demonstrate and validate the Estrella platform, European tax related legislation and national tax legislation of two European countries will be modelled and used in the pilot applications. The finance ministries or tax administrations of several other European countries will take part in an Observatory Board to ensure generality of the approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Forage Fish Interactions' (FACTS) targeting Seventh Framework.

assistant: **Abstract**

Removal of a forage fish has consequences for both predators and prey of forage fish. As everything is connected, every management action has a price which goes beyond the apparent, direct effect on the target species. The fishery on forage fish can therefore not be seen in isolation, as the immediate gain in profit from the fishery has to be discounted by the lowered potential for production of large piscivorous fish. Management actions on other species also influences forage fish, i.e. conservation efforts on marine mammals or sea birds have direct consequences for the predation pressure on forage fish. The objective of the project is to provide insight and quantitative advice on the ecosystem wide consequences of management actions directly or indirectly related to forage fish. The two overarching questions are: 1. What are the consequences of forage fish fisheries on (a) predator growth and abundance, (b) economic output of fisheries on piscivorous species, and (c) ecosystem stability and the risk for regime shifts? 2. What are the consequences of changes in predator populations on forage fish populations and fisheries? The methods is a combination of ecosystem models, of process studies aimed at feeding into the models, of economical models, and of data-analysis of existing data sources. The project covers four ecosystems in detail; Norwegian-Barents Sea, Baltic Sea, North Sea and Bay of Biscay. FACTS bring together leading European fisheries and university institutes working on creating the tools for ecosystem based management. The active involvement of the institutes in the current management provides a means for the results of the project to feed into management. The project furthermore includes a network component which ensures a wider dissemination of methods