RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial Ecology of the DEep Atlantic pelagic realm', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project aims at elucidating a major enigma in microbial ecology, i.e., the metabolic activity of prokaryotic communities in the deep sea under in situ pressure conditions, rather than under surface pressure conditions, as commonly done. Analysis of the global data set of prokaryotic abundance indicates that about 40% of prokaryotes reside in depth below 1000m depth with a phylogenetic composition different from that in surface waters. Using a recently fabricated high-pressure sampling and incubation system in combination with advanced tools to assess phylogenetic diversity, gene expression and single-cell activity, we will be able to resolve this enigma on a prokaryotic community level as well as on a phylotype level. This detailed knowledge on the distribution of the auto- and heterotrophic activity of deep-sea prokaryotes under in situ pressure conditions is essential to refine our view on the oceanic biogeochemical cycles, and to obtain a mechanistic understanding of the functioning of deep-sea microbial food webs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The analysis of thorium 232 in worplace materials Thorium 232 analysis' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives 1. To develop a network of European scientists involved in the analysis of radioactive metals in bulk materials. 2. To develop a proposal for the implementation phase (step 2) of a network in order to evaluate the proficiency of the analysis of Thorium 232, investigate sources of error and provide advice to industry and the European Commission concerning the analytical technique and methodology for this analysis. History Thorium is found as a contaminant in some mineral ores used in industrial processes Thorium itself is also used in a large number of industrial applications. It is harmful as it is radioactive and decays to an isotope of lead emitting alpha and gamma particles. The European directive Euratom 80/836 in 1980 requires that Member States oblige employers to report work activities involving materials that have a specific activity of more than 100 Becquels. Many different techniques can be used to measure Thorium 232 but it is not known how proficient these techniques are although a large number of scientific papers have been writen concerning this analysis. The Health and Safety Executive (HSE) in the United Kingdom (UK) has collaborated with the National Physical Laboratory (NPL)(UK) to develop a standard material in order to ascertain how accurately this analysis is performed. Initial evidence from a small intercomparison in the United Kingdom indicates that large errors may be associated with some techniques. Poor measurement quality in public and workplace monitoring may endanger life. The HSE and NPL proposes that a network of European experts is established in order to evaluate the most suitable technique for this analysis and to refine this technique further in order to reduce the errors and develop a standard method for the measurement of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Exploring the dynamics of the gastrointestinal tract using shed cell and spatial transcriptomics'.

assistant: **Innovation**

The gastrointestinal (GI) tract undergoes significant changes during post-natal development and in response to various diseases. Single-cell atlases are static and therefore fail to capture the dynamic changes occurring within the GI tract. We have devised a method to transcriptomically profile cells that are naturally shed into the GI tract. Contrary to earlier beliefs, we found that shed cells remain viable and can robustly be measured in fecal samples. Shed cell transcriptomics enables non-invasive tracking of cellular states throughout development and disease progression. Moreover, discrepancies between transcriptomic profiles of shed cells and tissues can identify which cell types are preferentially shed or retained, revealing cell turnover patterns. Our objective is to combine shed-cell and spatial transcriptomics to achieve basic and biomedical discoveries that were not possible before: 1. To study the developmental changes in the neonatal human GI tract. This will include longitudinal acquisition and in-depth analysis of shed cell transcriptomic and proteomic data in stool samples obtained from babies. 2. To characterize turnover of cells in colorectal cancer (CRC). We will combine shed cell transcriptomics in stool and blood with spatial transcriptomics of tumor biopsies to spatially map the cancer cells that resist death/shedding and examine their interactions within the tumor microenvironment. 3. To investigate cellular dynamics and tissue adaptations in Celiac disease. This will involve shed cell transcriptomics and high-resolution spatial transcriptomics to thoroughly understand the turnover rates of various enterocyte sub-populations and tissue adaptations during the disease. Our innovative use of shed cell transcriptomics will add a dynamic dimension to h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Authenticity-lednice' (AUTHENTICITY-LEDNICE) targeting Fifth Framework.

assistant: **Abstract**

The aim of the proposal is to organise Euro-conferences in 2000 and 2002 covering the scientific topic of modern analytical methods for food and beverage authentication and for quality testing. These events should be considered as a continuation of international conferences organised in Lednice in 1995 and 1997 with similar topics.The aim of the conferences suggested is the presentation of new analytical methods used in food and authenticity control. The focus will be on modern analytical methods (NMR, MS, IR, LC, GC, PCR, etc) accompanied by classical analytical procedures used in authentication of foods. The first conference should be considered as a satellite to the 5th Symposium on Food Authenticity organised in La Baule, France june 9-11, 1999. The duration of conferences in Lednice will be 3 days. There is expected to be the following research areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Control based on Human Models'.

assistant: **Innovation**

CON-HUMO focuses on novel concepts for automatic control based on data-driven human models and machine learning. This enables innovative control applications that are difficult if not impossible to realize using traditional control and identification methods, in particular in the challenging area of smart human-machine interaction. In order to achieve intuitive and efficient goal-oriented interaction, anticipation is key. For control selection based on prediction a dynamic model of the human interaction behavior is required, which, however, is difficult to obtain from first principles. In order to cope with the high complexity of human behavior with unknown inputs and only sparsely available training data we propose to use machine-learning techniques for statistical modeling of the dynamics. In this new field of human interaction modeling – data-driven and machine-learned – control methods with guaranteed properties do not exist. CON-HUMO addresses this niche.Key methodological innovation and breakthrough is the merger of probabilistic learning with model-based control concepts through model confidence and prediction uncertainty. For the sake of concreteness and evaluation the focus is on one of the most challenging problem classes, namely physical human-machine interaction: Because of the physical contact between the human and the machine not only information, but also energy is exchanged posing fundamental challenges for real-time human-adaptive and safe decision making/control and requiring provable stability and performance guarantees. The developed methods are a direct enabler for societally important applications such as machine-based physical rehabilitation, mobility and manipulation aids for elderly, and collaborative human-machine production systems. With its f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Microglia engineering and replacement to treat brain disease' under Horizon Europe.

assistant: **Concept**

Microglia are highly versatile brain resident cells that offer tremendous therapeutic opportunities. They are instrumental for maintaining healthy brain physiology and act as the primary modulators of neuroinflammation and disease. Microglial dysfunction has been convincingly linked to a myriad of neurological disorders, making these cells a prime target for therapeutic intervention. Remarkably, microglia are embryo-derived cells that self-maintain for life, with negligible replacement by the bone marrow. This astonishing self-renewal capacity offers a unique opportunity for cell therapy. The ability to replace dysfunctional microglia with healthy or genetically enhanced counterparts may transform the way we treat brain disease. But how can we replace a cell that is so adept at self-renewal in a tissue that is shielded from the periphery? Currently there are no translatable approaches for the specific replacement of microglia. Furthermore, bone marrow progenitors are unable to adopt the embryonic microglial phenotype. By building on our unpublished observations and developing innovative technologies, I aim to lay the foundation for microglial replacement therapy. We intend to develop an original and translatable strategy for the specific and near-complete replacement of embryonic microglia with adoptively transferred progenitors. Next, by combining iPSC differentiation with genetic barcoding, single-cell analysis and in vivo screening, we aim to identify progenitors that efficiently traffic to the brain and engraft as bona fide microglia. Moreover, we will investigate how we can transform microglia into local protein production factories, as a potential basis to treat neurodegenerative diseases. Finally, we will set up in vivo pooled CRISPR screens to identify the gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ancient Battles, New Weapons: Uncovering Germline Defense Innovations and Transposon Invasions in Caenorhabditis species' (TEvsRNA).

assistant: **Concept**

The germline is the only immortal lineage in animals, making it a target for transposable elements (TEs) to perpetuate themselves at the host's expense. To counter these threats, animals utilize Piwi-interacting RNAs (piRNAs) to suppress TEs and maintain germline integrity. Despite the crucial role of piRNAs, the diversity of mechanisms organisms use to repress parasitic elements remains largely unexplored. To address this, I propose studying an emerging model system, the nematode Caenorhabditis plicata; one of the few Caenorhabditis species that lost the piRNA pathway. Notably, our preliminary results indicate that C. plicata employs novel small RNA (sRNA) classes to silence TEs. My first aim is to dissect the molecular basis of this sRNA pathway and elucidate its evolutionary origins. To do so, I will screen for the underlying molecular component controlling this pathway; firstly by targeting homologs of proteins involved in C. elegans sRNA silencing, and secondly, via EMS mutagenesis to identify mutations that suppress silencing of transgenic reporters. I will then investigate whether the novel sRNA populations are ancestral or a recent innovation by examining independent piRNA loss events across different Caenorhabditis species. Motivated by the natural loss of piRNAs and the widespread transfer of TEs between species, my second aim is to develop an experimental model to study foreign TE invasions in nematodes through heterologous insertions of TEs into mutant worms that are unable to defend against these elements. I will then examine the subsequent impact on genome architecture and explore whether they contribute to genome size expansion. This comprehensive approach will not only teach us how animals protect their germline but also deepen understanding of how biolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'D-branes in String Theory' (2002-2006).

assistant: **Innovation**

String theory is a candidate theory for extending the Standard Model of elementary interactions to include gravity in a unified quantum theory. D-branes are extended objects central to modern string theory, as they seem to unlock the non-perturbative structure of string theory, and may ultimately lead to experimental tests of stringy phenomenological models.This project will analyse three aspects of D- branes in string theory. Firstly, it will investigate D-branes in non-geometric backgrounds, which describe compactifications of string theory to four dimensions. Particular emphasis will be placed on finding new, less symmetric D-branes than those already identified in the literature. Secondly, the project will examine the behaviour of D-branes under the well-known duality symmetries of string theory. A general framework for this will be constructed using orbifold and orientifold backgrounds.The third part of the project will analyse D-brane interactions in the plane-wave background and their relation to gauge theory in light of the gauge/gravity correspondence. The proposed comparison will allow for an extension of this duality to the non-perturbative regime. This project is at the forefront of today's string theory research and has important theoretical and empirical applications. It investigates several significant gaps in the string theory literature relating to D-branes.This project will draw on the applicant's previous research on D-branes and on interactions with several members of the Theoretical Physics Group at Imperial College London. In accordance with the activity's objectives this project will allow the candidate to undertake advanced training at the host institution with the aim of increasing his skills and establishing himself as an independent researcher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mammalian cloning in Europe: prospects and public policy' under Fourth Framework.

assistant: **Concept**

This study is designed to provide an assessment of mammalian cloning technology, its possible risks and benefits, and how public policy might help steer its development in a manner which is both socially acceptable and economically useful. The creation of the first cloned mammal, 'Dolly' the sheep, has been seen as a landmark, demonstrating both the power of science and the scale of public fears surrounding genetic engineering. This technical achievement has provoked controversy and stimulated major public policy debates in many countries, with the emphasis on the ethics of cloning humans. However, fear of human cloning has overshadowed the longer-term significance of this research, as it is in the field of animal biotechnology and in the development of new medical technologies that cloning could provide major benefits. Public policy makers are therefore faced with a dilemma in balancing the need to maintain public confidence in biotechnology, by guaranteeing that research on cloning is ethical and socially acceptable, whilst at the same time ensuring that regulation will not inhibit its industrial exploitation. The objectives of the study are therefore to: 1. Assess the scientific significance of the cloning of mammals and identify both short and long-term potential applications of the technique; 2. Make a comparative analysis of the public perception of mammalian cloning, the ethical problems raised, and the public policy response to these issues, in the UK and the Netherlands; 3. Analyse the relative success of different national approaches to mammalian cloning and suggest how public policy might be best used to socially manage the technology in Europe. To meet these objectives the work programme will be composed of the following activities: - A detailed literature r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An Antibody Microarray for Histone Modifications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Histones are the major structural proteins of eukaryotic DNA. Two copies each of the core histones, H2A, H2B, H3 and H4, form the core nucleosome, the basic unit of chromatin. Histone tails protrude from the nucleosome structure and are subject to a variety of post-translational modifications on multiple residues, including methylation, acetylation, phosphorylation, sumoylation, ubiquitination and polyribosylation. These histone modifications dictate local and global structure of chromatin, rendering it active and decondensed (‘euchromatic’) or suppressed and compact (‘heterochromatic’) by the recruitment of chromatin-binding proteins that recognize and associate with specific modifications. Histone modifications are therefore the basic regulatory unit of gene expression, genomic silencing, developmental programs, cell division and essentially all cellular processes. Understanding this so-called ‘epigenetic’ landscape is therefore vital for all biological mechanisms. Currently a Western blot is required in order to determine the state of each of the dozens of different histone modifications. Because of the growing number of histone modifications, this procedure is time consuming and labour intensive. Here I suggest to develop an antibody microarray to monitor the levels of all histone modifications simultaneously. This method will be essentially useful for any tissue or cell type in any biological process, for diagnosis, prognosis and drug screening. In addition to basic research, our platform will enable fast and reliable screening for epigenetic effects of existing and novel drugs. We believe that such a product could serve many drug companies interested in direct and indirect effects of epigenetic and non-epigentic drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Energy and resource surveillance systems without the challenges of batteries' (RePower), addressing dissemination and exploitation.

assistant: **Impact**

ProblemWaste and overconsumption of resources are major challenges in EU, as it leads to unnecessary environmental burdens and economic loss. Research has shown that continuous detailed surveillance of the energy consumption yields savings of 10 to 70 %.  The customers states, however, that the use of batteries in the needed sensor systems is a major barrier. The reasons are (A) it is difficult to change sensor batteries, especially on sensors hidden behind e.g. ceilings or walls, (B) the fire hazard, and (C) the environmental burdens of using batteries.SolutionRePower deliver battery-less sensors to monitor technical installations in e.g. buildings, by harvesting the energy from the outside of multicore power cables, without damaging the cable in any way. RePower thereby disrupts the market for sensor systems, by enabling battery-less sensors in an environment where batteries has been the only option, until today.Compared to other sensor energy sources, RePower is:-Usable in building installations-Cost-efficient-Non-invasive-Long-life-Safe-Made for slim designsProjectAt the current stage, a prototype of RePower is developed and patented. In Phase 1 RePower will be business develop and demoed. In Phase 2, it will be implemented in our sensor platform, matured for efficient serial production, and the business will be updated for sales at the international markets.BusinessIn year three to five after market-launch, we expect a yearly turnover of 1.3 million RePower units, delivering a revenue of 68 million €, mainly from our own sensor platform, but also from selling RePower to OEM customers.MarketOur first customer segment is non-residential buildings, because these customers are aware of the challenges of using batteries. Later on, we aim for the residential buildings an