RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Decarbonized Steel Production with Novel Processes'.

assistant: **Concept**

The ZEROSTEEL project aims at reducing the CO2 emissions in the steel production applying novel technologies, integrating green hydrogen, coming from local networks and electrolyzers, for the direct reduction of the iron ore. In particular, four novel direct reduction processes will be applied which will be integrated from hydrogen or/and renewables, namely (a) the Circored Fluidized Bed (CFB), (b) the rotary kiln direct reduction, (c) the hydrogen plasma smelting reduction and (d) the molten oxide electrolysis. Additionally, the possibility of utilizing biomass to produce green hydrogen will be also investigated, aiming at the valorisation of biobased residues as well as the development of a Digital Twin for AI-based steel quality monitoring. Biochars will be also be produced from the biomass utilization which will be applied as alternatives foaming agents at the EAF process. At last novel hydrogen- based hydrogen-based technolgiestechnologies will be integrated in the forming and shaping of the steel closing the loop of the zero emissions technologies for the steel production.  The above-mentioned activities will be completed by a detailed life cycle and environmental assessments along with a clear business case for the exploitation of project’s activities and the corresponding business plan.


**Keywords:** hydrogen, biomass, green steel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International symposium on luminescent detectors and transformers of ionising radiation 2003' (LUMDETR2003).

assistant: **Concept**

The first announcement 1st July 2002. The second announcement and call for papers 31 October 2002 Deadline for abstracts 1st February 2003 Notification to authors and the third announcement and registration forms 31 the March 2003 Advanced registration 15th June 2003 Conference event and the manuscript refereeing start-up 31/8 - 5/9 2003 Submission of conference manuscripts to Levier 31 January 2004
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Models for performance and control of stochastic networks' to be submitted under Fifth Framework.

assistant: **Abstract**

I propose to investigate four important problems for stochastic networks:1. Performance of processor sharing networks;2. performance of processor sharing queues with deadlines;3. the waiting time distribution in ( exhaustive ) polling systems with heavy tailed service time and/or inter arrival time distributions; and4. dynamic control problems related to the scheduling of jobs in large scale processing computers. The first two problems represent logical directions in which to build on the techniques developed during my dissertation research. The objective is to obtain heavy traffic limit theorems for certain measure valued processes which describe the performance of processor sharing networks.For problem 1, the networks considered will vary in complexity, beginning with a singe processor sharing queue with multiple input classes, progressing to feed forward networks of processor sharing queues, and ultimately including more general networks that are not necessarily feed forward.For problem 2, a single processor sharing queue is considered, but with service deadlines attached to each job entering the system. The objective for problem 3 is to prove a heavy traffic limit theorem for the waiting time distribution in the above polling system. This will require entirely different techniques than needed for problems 1 and 2. The objective for problem 4 is to find good scheduling policies for parallel processing facilities which can choose how to a lot their resources (how many processors to assign) to incoming jobs. As there is little theoretical knowledge for this system, the investigation will begin with a performance analysis of some policies commonly in use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cell division and the origin of embryonic aneuploidy in preimplantation mouse development' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cell division is fundamental for development. In the early mammalian embryo it drives the rapid proliferation of totipotent cells, the basis for forming the fetus. Given its crucial importance, it is surprising that cell division is particularly error-prone at the beginning of mammalian life, resulting in spontaneous abortion or severe developmental retardation, the incidence of which is increasing with age of the mother. Why aneuploidy is so prevalent and how early embryonic development nevertheless achieves robustness is largely unknown. The goal of this project is a comprehensive analysis of cell divisions in the mouse preimplantation embryo to determine the molecular mechanisms underlying aneuploidy and its effects on normal development. Recent technological breakthroughs, including light sheet microscopy and rapid loss-of-function approaches in the mouse embryo will allow us for the first time to tackle the molecular mechanisms of aneuploidy generation and establish the preimplantation mouse embryo as a standard cell biological model system. For that purpose we will develop next generation light sheet microscopy to enable automated chromosome tracking in the whole embryo. Mapping of cell division errors will reveal when, where, and how aneuploidy occurs, what the fate of aneuploid cells is in the embryo, and how this changes with maternal age. We will then perform high resolution functional imaging assays to identify the mitotic pathways responsible for aneuploidy and understand why they do not fully function in early development. Key proteins will be functionally characterised in detail integrating light sheet imaging with single molecule biophysics in embryos from young and aged females to achieve a mechanistic understanding of the unique aspects of cell division
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transforming Raw Data into Information through Virtualization' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The unprecedented evolution of computing power, combined with the decreasing costs of computation and storage infrastructure, has revolutionized all scientific fields and enterprises; at the heart of this revolution is the ability to collect unprecedented amounts of data. Real progress, however, depends on how efficiently we can ‘extract value from chaos’, i.e., process the collected data and transform it into useful information. Unfortunately, despite the impressive growth of data management technologies,  data analysis application efficiency is hindered by the increasing data growth. The typical business intelligence architecture is far too complex to yield answers productively, with businesses operating large numbers of specialized data processing systems, with data being repeatedly moved, copied or transformed between them. The reason is that, despite tremendous progress, data management tools are based on legacy designs whose requirements are no longer adequate. A novel approach is needed urgently, or users risk losing the ability to leverage their hard-earned data.In this proposal, we identify assumptions that do not scale with today’s massive data explosion, and design a comprehensive end-to-end solution that implements a novel form of data virtualization to vastly simplify data analysis. Our approach removes barriers to data handling and maximizes efficiency for science, businesses, and their users, by enabling new forms of data computation that are unrestrained by how data is collected or stored. This project constructs the building blocks for data-driven computing and the fourth paradigm of scientific discovery, thereby advancing our ability to automatically explore massive and complex datasets at sight, and dictate the new developments in sciences and the ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Exploring the three-dimensional nanoscale space around defects in Ni-based superalloys for aircraft applications employing atom-probe tomography'.

assistant: **Concept**

The research proposed is part of an extensive work aimed at investigating the formation of defects during the solidification of Nickel-based superalloys, where the goal is establishing criteria that enable avoiding their formation. We intend to employ the latest version of the Atom-Probe Tomograph, namely the Local-Electrode Atom-Probe (LEAP), which is the best analytical experimental tool available today for characterizing the chemistry of solid materials in the sub-nanometric scale. The results obtained by LEAP will be used as input data for ab-initio Molecular Dynamics (AIMD) simulations and compared with nano-mechanical testings.  The approach of combining both LEAP tomography results with mechanical behavior in the nano-scale, as well as implementing AIMD, may serve as a very powerful tool in the understanding of materials science fundamentals, e.g. the correlation between mechanical properties, composition, and morphology.  Specialization in the most powerful atomistic-tomography tool known today, the LEAP, is essential for preserving the high level of scientific research in Israel, thus encouraging further scientific collaboration between Israel and other EU countries as well as the USA.   We intend to perform the LEAP characterization work as well as the analytical modeling at the Northwestern University Center for Atom-probe Tomography (NUCAPT) leaded by Prof. David Seidman. The rest of the research work including Transmission Electron Microscopy (TEM) as well as computer-aided simulations will be performed in the return stage at the Technion, Faculty of Materials Engineering, and leaded by Prof. Wayne Kaplan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural Biology of Exopolysaccharide Secretion in Bacterial Biofilms' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Bacterial biofilm formation is a paramount developmental process in both Gram-positive and Gram-negative species and in many pathogens has been associated with processes of horizontal gene transfer, antibiotic resistance development and pathogen persistence. Bacterial biofilms are collaborative sessile macrocolonies embedded in complex extracellular matrix that secures both mechanical resistance and a medium for intercellular exchange. Biogenesis platforms for the secretion of biofilm matrix components - many of which controlled directly or indirectly by the intracellular second messenger c-di-GMP - are important determinants for biofilm formation and bacterial disease, and therefore present compelling targets for the development of novel therapeutics. During my Ph.D. and post-doctoral work I studied the structure and function of c-di-GMP-sensing protein factors controling extracellular matrix production by DNA-binding at the transcription initiation level or by inside-out signalling mechanisms at the cell envelope, as well as membrane exporters involved directly in downstream matrix component secretion.Here, I propose to apply my expertise in microbiology, protein science and structural biology to study the structure and function of exopolysaccharide secretion systems in Gram-negative species. Using Pseudomonas aeruginosa, Vibrio spp. and Escherichia coli as model organisms, my team will aim to reveal the global architecture and individual building components of several expolysaccharide-producing protein megacomplexes. We will combine X-ray crystallography, biophysical and biochemical assays, electron microscopy and in cellulo functional studies to provide a comprehensive view of extracellular matrix production that spans the different resolution levels and presents mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.'.

assistant: **Innovation**

How do we learn to dance, play an instrument, or a game as complex as chess or go? How do we make a memory? The common answer to these questions is “through synaptic plasticity”, through changing the synaptic connectivity of neural circuits so that representative brain activity can be reliably triggered. Such connectivity changes are governed by rules, i.e., synaptic mechanisms which monitor the activity of their environment and stereotypically strengthen or weaken synapses accordingly. The shape and mode of operation of these rules is still largely unknown: For the more than hundred different connection types in cortical circuits, only a handful of rules has been described at all. Similarly, testing observed rules in simulations of cortical function has only seen limited success. Our slow progress is due to the extraordinary difficulty of measuring and observing synapses without interference.Here, we propose a new approach. By utilizing the growing power of machine learning methods we can deduce synaptic plasticity rules directly. Newly developed search algorithms and sheer computational power allow us to integrate published data and infer synaptic rules in silico. We aim to (1) develop a new mathematical expression of synaptic plasticity rules, experimentally appropriate and flexible enough to be implemented in a Machine Learning framework, dubbed SYNAPSEEK. Next (2), we will apply SYNAPSEEK to deduce the rules for building various neural structures with increasing complexity. Finally (3), we will incorporate additional constraints to SYNAPSEEK to develop synaptic rules that shape network function as much as its structure. Our work will establish, for the first time, canonical sets of synaptic plasticity rules, based on the circuit structure they must produce, and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Long-term potentiation and learning in freely moving psd-95 mutant mice' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Our goal is to study the relationship between learning ability NMDA receptor and LTP using the PSD 95 mutant mice. In vitro studies show that these mice exhibit larger LTPthan wild type. We will induce LTP in vivo on mutant and wild type mice before and after groups of both types will be subjected to a battery of spatial and non-spatial learning task.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regeneration of Sinusoidal niches to preserve hematopoiesis after chemotherapy on Ageing' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cancer is a disease of the elderly and chemotherapy remains the mainstay of treatment. The benefits of chemotherapy include increased overall survival, improvement in quality of life, and palliation of symptoms. However, older patients are more susceptible to specific toxicities of chemotherapy, like myelosuppression and life-threatening neutropenia. Among the tissues strongly affected by chemotherapy, the bone marrow sinusoidal endothelial cells constitute the most important supportive niche for aged hematopoietic stem cells function and for myelopoietic recovery in the elderly. Up to now, few data are available about how aged sinusoidal niches regenerate upon chemotherapy damage and whether it is possible to rejuvenate vascular endothelial stem cells and improve the regeneration of the old sinusoidal niche as an effective strategy to improve HSC function and prevent myelosuppression and life-threatening neutropenia in the elderly.Here I hypothesize that the reduced regenerative capacity of aged sinusoidal niches can be improved by rejuvenating vascular endothelial stem cells in vivo via targeting Cdc42 activity and the Notch:Jag2 signaling. The current proposal investigates whether improving the regeneration of the aged sinusoidal niche might represent an important target to enhance the hematopoietic recovery and increase the survival after chemotherapy in the elderly. By combining several ground-breaking approaches ranging from single-cell sequencing, whole-mount bone marrow imaging, deep learning strategies for data analysis and integration, stem cell sorting techniques and specific mouse models, this research project will demonstrate that aging is not irreversible and that targeting the stem cell niche could represent an unprecedented innovative strategy to improve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A sustainable organic solution for bees decline' under Horizon 2020.

assistant: **Concept**

With 630.000 beekeepers and 16 millions of hives, the apiculture sector is an important part of the EU agriculture. In addition, honeybees play the crucial ecosystem service of pollination, guaranteeing also the maintenance of the biodiversity. However, since a few decades, apiculture is facing important losses.However, since a few decades, apiculture is facing important losses due to abiotic and biotic factors. American foulbrood (AFB), caused by the spore-forming Paenibacillus larvae ssp. larvae is the most The project aims to tackle the global bee health challenge by developing a feasibility study for MICRO4BEE, an eco-innovative product representing a sustainable solution to decline of bees caused by bacteriological diseases. The product is patented by Micro4yoU, a company transferring research results into the development of innovative microbial-based green technologies and seizing National, European and global business opportunities. In Europe, no products are on the market to fight against bacterial pathogens and MICRO4BEE meets an urgent market need: it may achieve a high level of approval from beekeepers, for whom to date the only possible response to these diseases is to destroy the hives. MICRO4BEE represents an innovative product composed of a mix of symbiotic bacteria, naturally present in the gut of bees, harmless to humans and with probiotic activities towards honeybees. Although first target customers are organic producers (aprox. 10%-15% of beekeepers), due to the lack of valid chemical alternatives also non-organic producers are an interesting market segment, at EU and global markets level. The feasibility study will cover regulatory, market, economic and financial analysis,  the refinement of the IP management strategy and the operative options associ