RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Situation AWare Security Operations Center' (SAWSOC).

assistant: **Concept**

SAWSOC aims at bringing a significant advancement in the convergence of physical and logical security, meaning effective cooperation (i.e. a coordinated and results-oriented effort to work together) among previously disjointed functions. Recently some achievements have been made (e.g. SEM and SIM have merged into SIEM, and LACS and PACS have merged into IM), Security Operations Center (SOC) technology has improved significantly, but much is yet to be done. SAWSOC holistic approach and enhanced awareness technology will allow dependable (i.e. accurate, timely, and trustworthy) detection and diagnosis of attacks. This will ultimately result in the achievement of two goals of paramount importance, and precisely: 1) Guaranteeing the protection of citizens and assets, and 2) Improving the perception of security by citizens. Goal 1 is in line with the objectives of the Security Work Programme in general, and goal 2 perfectly matches the expected impact as listed in the Work Programme for Topic SEC-2012.2.5-1. SAWSOC’s design will be driven by three real use cases, with highly diverse requirements. Such use cases collectively form an experimental test-bed perfectly suited for driving the design as well as for validating the development of a platform such as SAWSOC that will support true convergence of physical and logical security technologies, and overcome the fragmentation of security approaches. The first use case deals with the protection of a Critical Infrastructure for Air Traffic Management. The second deals with the protection of a Critical Infrastructure for Energy Production and Distribution. The third deals with the protection of a public place, specifically a stadium, during an event. The project will take stock of associated initiatives, which have a direct or ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Extracellular vesicles-mediated cross-talk during human brain development and disease' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Cellular cross-talk is an essential process influenced by numerous factors including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neuron-to-neuron communication while the role of EVs in progenitor-to-neuron and -astrocyte communication occurring during brain development has not been systematically investigated. Extracellular signals regulating the development of the brain are key players altered in many neurodevelopmental disorders (NDDs). Strikingly, we have found that more than 60% of the genes associated with NDDs encode for proteins that are loaded into EVs.With ExoDevo, inspired by new cell-non-autonomous mechanisms that we have identified as the cause of  NDDs, I will investigate the role of EVs during brain development. I will focus on the physiological function of EVs that mediate the signals for cell-to-cell cross-talk and combine transcriptomic, proteomic, imaging, and functional analysis of EVs derived from human cerebral organoids. This will open new avenues in order to tackle fundamental questions, such as how different cells communicate and feedback at different times and distances in the highly dynamic process of brain development. Ultimately, this will be investigated in human models of NDDs and will allow me to identify pathologically altered cellular cross-talk mediated by EVs. This knowledge of the cellular processes governing EVs biology will provide the basis to better understand novel mechanisms underlying brain development and neurodevelopmental human pathologies and explore new deliverable compounds for therapy. My expertise in human brain development and diseases together with the possibility of combing multiple technologies will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Determination of earthquake source parameters in geologically compl ex media', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Foreseen ResultsThe theoretical component will address the problems of the inversion routine itself and the modelling of seismic wave propagation in a complex medium and the experimental component will test the algorithms developed during the theoretical phase.The ability to determine sufficiently accurate source parameters from earthquakes is an important element of any seismic hazard assessment. The proposed project addresses one key aspect of this topic : the design, optimization and validation of a seismic waveform inversion scheme for the retrieval of mechanism and rupture history information for an earthquake buried in a complex medium. These complexities include the anisotropy of the medium surrounding the focus and the presence of discontinuities close to the source which correspond to the types of structural complexities which are found in nature.The proposed project will include complementary theoretical and experimental components. For this purpose data from a series of controlled experiments from Atomic Energy of Canada Ltd's Underground Research Laboratory (URL) will be used. This research facility offers a unique opportunity to study both controlled acoustic sources and natural mining induced earthquakes , in a controlled environment.This project builds on existing collaboration between the partners involved : Geophysical Institute of the Czech Academy in Prague and the University of Hamburg in the modelling of elastic waves in complex media, and the University of Keele and the Czech Academy concerning the link between inverse problems and the modelling of experimental data from the controlled environment of the URL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Model Predictive Control and Innovative System Integration of GEOTABS;-) in Hybrid Low Grade Thermal Energy Systems - Hybrid MPC GEOTABS' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The MPC-: GT project brought together a transdisciplinary team of SMEs, large industry and research institutes, experienced in research and application of design and control systems in the combined building and energy world. Based on prior research, supported by (joint) EU and national projects, and practical experience the bottlenecks where identified that prevent at this moment a real breakthrough of geothermal heat pumps (GEO-HP) combined with thermally activated building systems (TABS) - GEOTABS. Solutions, which need to be implemented in an integrated way, were identified and sufficient proof of concept was gathered to join forces in a RIA.The innovative concepts aim at increasing the share of low valued (low-grade) energy sources by means of using low exergy systems on the one hand and aim at upgrading low/moderate temperature resources on the other hand.The overall solution consists of an optimal integration of GEOTABS and secondary supply and emission systems.To allow for an optimal use of both the GEOTABS and the secondary system, a split will be made between a so-called “base load” that will be provided by the GEOTABS and the remaining energy needs that should be supplied by the secondary system. A generic rule, eliminating case-by-case simulation work, will be developed.The second part of the proposed solution aims at a white box approach for Model Predictive Control (MPC)  to generate a controller model with precomputed model inputs such as disturbances and HVAC thermal power to avoid case by case development. Research is needed to assess the overall performance and robustness of such an approach towards uncertainties.As such, the MPC-: GT consortium believes to have identified an integrated solution that will provide a near optimal design strategy for the M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanistic basis of host infection and intracellular development in microsporidia', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Microsporidia are emerging pathogens of high priority that infect humans, and most animals. Microsporidiosis can be life-threatening and cause severe damage in the eyes, brain, muscles, respiratory, and urinary tracts. These obligate intracellular parasites also present a unique case of reductive and divergent evolution. They possess the smallest eukaryotic genome and unique cellular features such as the smallest eukaryotic cytoplasmic ribosomes and a specialised infection apparatus, the polar tube. Inside the host, microsporidia replicate through distinct life stages to form infective spores that are released into the environment upon host cell lysis. However, the molecular events involved in the pathogen’s commitment to each life stage, host cell lysis, formation, and eversion of the polar tube, remain unclear. This lacunae in understanding microsporidia are due to a lack of biochemical or structural data and the absence of systematic in vivo studies. Thus, studying this medically and economically relevant pathogen is critical for designing drugs and preventive regimes to curtail their transmission. Towards this, MsInfection aims to provide the first comprehensive and mechanistic insights into microsporidian life-cycle progression and host cell invasion. The life cycle stages of microsporidia species with varied tissue tropism will be analysed structurally and transcriptomically at the single-cell level, using Electron Microscopy (EM) and single cell-RNA sequencing (scRNA-seq). A combination of these transformative technologies will enable a systematic determination and visualisation of the molecular events driving intracellular development, and the assembly of infection apparatus and tissue niche selection.


**Keywords:** Microsporidia,  cryo-SBF, SEM, cryo-Electron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REACT - Reintegration from Armed Conflict: A Comparative Study of Youth Reintegration from Armed Conflict in Iraq and Gaza' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

To what extent can female and male youth engaged in armed conflict be reintegrated into their communities? My project REACT (Reintegration from Armed Conflict) seeks to answer this question through a cross-regional analysis of two contexts: Iraq and the Gaza Strip. Having almost completed my research in the Gaza Strip,  REACT will concentrate almost exclusively on Iraq to understand similarities and differences in how youth perceive the possibility of  reintegration; and how this interacts with the expectations of their communities, the national government, and the humanitarian and development sector. REACT seeks to contribute to studies on youth in armed conflict, using approaches drawn from social anthropology, critical security studies and social network theory, and based on field research in Gaza and Iraq. REACT departs from the idea that criminalization or (conversely) the treatment of youth as passive victims of adult coercion are effective ways of responding to young people who have been affiliated with armed groups. Instead, this project invites a more complex understanding of the meaning and feasibility of reintegration by directly engaging with youth and their communities, arguing that approaches to engaging with youth formerly affiliated to armed groups should be grounded in their perspectives, as well as those of local ethnic networks and economies. By expanding current knowledge around reintegration and its related policies, the project also aims to provide an empirical platform for policy engagement. Based at the Centre on Conflict, Development and Peacebuilding (CCDP) within IHEID, I will train in critical security studies and social network analysis under the supervision of Prof. Riccardo Bocco. Located in the global hub of the humanitarian and developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Effects of permafrost thaw on the global nitrogen cycle: the role of thermokarst systems'.

assistant: **Concept**

Global change leads modifications in climate on Arctic regions, where temperatures have risen faster than in any other region on Earth. Those regions store vast amounts of soil organic matter (SOM) in permafrost soils, covering ~25% of terrestrial surface. When they thaw, it leads to rapid release of nutrients and greenhouse gases (GHG). So far, many studies have addressed the importance of permafrost thaw in the carbon cycle. However, little attention has been paid to the nitrogen (N) cycle, despite nitrous oxide (N2O) is a powerful GHG, an ozone-depleting agent and may create an unaccounted permafrost-climate feedback.Permafrost with low ice content suffers a gradual top-down thawing process during seasonal freeze-thaw period. However, thaw of ice-rich permafrost results in thermokarst processes, which occur abruptly and lead to ground surface collapse. Its widespread occurrence affects large areas (~40% of the northern permafrost region) contributing to develop ecosystems like ponds and lakes. In such ecosystems, the presence of anaerobic environments enhances microbial activity. As Arctic warms, permafrost thaw and thermokarst processes will increase, releasing soluble N into the environment and enhancing microbial decomposition of SOM.Hence, mineralization, nitrification and denitrification rates are expected to increase, and thus, N2O emissions to the atmosphere. Unfortunately, the impact of permafrost thaw on N cycling remains understudied, and almost unknown in thermokarst systems. NITROKARST will explore the underlying mechanisms of the N cycle in thermokarst systems, looking at how microbial pathways promote N transformation and how thawing controls the operation of these processes. N cycling will be studied along a thermokarst transect by combining isotope tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A study of improving dissemination of biotechnology research to EU bio-industry' to be submitted under Fourth Framework.

assistant: **Abstract**

The primary objective of this proposal is to disseminate results of the Biotechnology Programme directly to industry users and indirectly through relevant technical periodicals, industry newsletter and other media channels. BioResearch Ireland (BRI) and the European Secretariat of National BioIndustry Associations (ESNBA) jointly propose to develop and manage a system for dissemination of useful R&D results from the current and previous biotechnology programmes to EU bio-industries, and particularly to SME's. The proposers intend to achieve this goal by dissemination of technology opportunities: (a) Through the technical and trade periodials which are regularly consulted by the biotech-related industries in Europe. (b) Directly to relevant industries through their representative organisation - ESNBA and its members organisations. This proposal will involve the sourcing and preparation of twelve technology transfer opportunity releases per year, in suitable formats for publication and direct dissemination. The proposers envisage a three year period for the project. The activity of this proposal conforms to the objectives of the Preparatory, accompanying and support measures outlined in the workplan. The proposal directly involves the promotion of the exploitation of results and the publication and dissemination of information on biotechnology research and related activities and on the impact of the application of research results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Image Guided Local Drug Delivery from Nanocarriers  using Focused Ultrasound' under Seventh Framework.

assistant: **Concept**

The principal objective of the Sound Pharma project is to increase the therapeutic index of potent, often toxic treatments through personalized image-guided treatment, which ultimately decreases adverse effects of drugs by better controlling the pharmacokinetics (PK) and pharmacodynamics (PD) of therapy.  For local disease, exogenous energy will be used to to release drugs entrapped within nanoparticles circulating through the tumor. This will be achieved via a combination of Focused Ultrasound, and drug nanocarriers that are sensitive to bio-effects of ultrasound.The drug ¿magic bullet¿ is at the heart of Pharma¿s business model. However, targeted drug delivery is increasingly being recognized as a key limiting factor of drug efficacy. Nanotechnologies are providing new formulations as well as novel methods for targeting. The combination of nanotechnologies and external triggering will provide novel technologies to achieve spatio-temporal control of drug delivery. The effect of ultrasound in tissue allows the local deposition of drugs from nanocarriers circulating in the blood, and/or their local activation. This is the case when using nanocarriers sensitive to mechanical forces and/or to small temperature elevations. Extravasation and membrane permeability are also enhanced by ultrasound. This new field of Image Guided Drug Delivery opens up opportunities for Pharma to expand applications for their existing small drugs (e.g. doxorubicin, cisplatin, irinitecan) in cancer by altered pharmacokinetics.  This project intends to develop new focused ultrasound methods for drug delivery, based on local control of temperature and pressure, and by monitoring and validating intracellular uptake in real time using optical and MRI methods. The developed FUS methods will be applied
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spin Control in Radical Semiconductors' (SCORS), addressing dissemination and exploitation.

assistant: **Impact**

SCORS will deliver a paradigm change for organic semiconductor science and technology by exploring and developing the electronic and optical properties of radical (spin ½)-based organic semiconductors (ROSCs).  The proposer has recently discovered these can show very efficient photoluminescence and can support efficient organic light emitting diodes (OLED) operation within the spin doublet manifold. SCORS will comprise five key themes:1) Develop and synthesize new structures for ROSCs to control emission colour and efficiency, explore fundamental mechanisms for high luminescence yield, and search for optical gain. Targets: efficient red and IR emitters out to 1µm;  optically driven cw-lasing.2) Establish the use of doublet excited states for their spin-allowed interconversion with both singlet and triplet excitations in OLED structures. Target: New OLED designs that use fast luminescence ROSCs materials in OLEDs with conventional singlet/triplet semiconductors such as TADFs, with high efficiencies (EQE>25% at high brightness (1000 cd/m2). 3) Develop IR-emitting ROSCs that energy-match triplet excitons formed in singlet exciton fission systems. Targets: doublet systems as optical emitters for singlet fission based down-conversion to improve photovoltaic efficiency. Search for direct singlet to triplet-doublet pair fission.4) Use of ROSCs in Organic Photovoltaics (OPVs) to provide light absorbers that are designed to have no lower-energy (and therefore quenching) excitations. New materials designs to delocalize electron and hole wavefunctions will be developed. Target: a paradigm shift for OPVs - high luminescence efficiencies enabling high open circuit voltage, with non-radiative recombination voltage loss < 100 meV.5) Explore the control the ground state spin polarisati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Policy Options for the Sustainable Use of Coral Reefs the Associated Coastal Ecosystems .'.

assistant: **Concept**

The Workshop will discuss policy options for the sustainable management of coral reefs and associated coastal ecosystems. This is a broad, multipurpose endeavour aimed at improving the quality of life of community's dependant on coastal resources and helping coastal states to attain sustainable development. Since the management of coral reef ecosystems has diverse sectoral and regional implications the Workshop emphasizes an interdisciplinary approach highlighting issues such as property rights, management options for common pool resources, protected area and habitat management, and monitoring and enforcement institutions. The Workshop will create a forum of exchange which allows for better pooling of marine policy expertise. Intensified collaboration between EU and developing country researchers as well as private companies will be major results.