RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hepatocyte Growth Factor and Insulin Resistance' to be submitted under Seventh Framework.

assistant: **Abstract**

Insulin resistance is a hallmark of human diseases, including diabetes and obesity, which lead to abnormal glucose and lipid metabolism as a result of impaired metabolic response to insulin. The mechanism underlying the development of insulin resistance remains incompletely understood. Excessive production of pro-inflammatory cytokines by the adipose tissue is linked to insulin resistance. Hepatocyte Growth Factor (HGF) is an adipocytokine elevated in obese subjects, which strongly correlated with the metabolic syndrome. However the role of HGF in the etiology of the insulin resistance remains unknown. Recently, we have demonstrated that HGF is a potent activator of glucose transport and metabolism, and also a strong inhibitor of fatty acid oxidation in rodent myotubes (Perdomo et al., J. Biol. Chem., 2008). In addition, we have generated (i) a conditional transgenic mouse of HGF in the skeletal muscle, and (ii) a conditional knockout mouse of the HGF receptor (c-met) in skeletal muscle. We hypothesized that HGF ameliorates skeletal muscle insulin resistance in vivo. To test this hypothesis, we propose two aims: 1) To investigate the relationship between plasma HGF levels and insulin resistance in humans. 2) To investigate the role of HGF in the insulin-resistant skeletal muscle. Accomplishing this project will elucidate the relationship between plasma HGF levels and insulin resistance in humans and determine its contribution to the etiology and pathophysiology of insulin resistance. A mechanistic understanding of insulin resistance will facilitate the development of therapeutic strategies and identification of new drug targets in the prevention and treatment of diabetes and obesity. Finally, my preliminary data have provided feasibility for the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Global regulation of lipid biosynthesis in Gram-positive bacteria: structural and biochemical characterization of FapR' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

FapR is a transcription factor that negatively controls the expression of several genes of the fatty acid and phospholipid biosynthesis in Bacillus subtilis. It is the first global regulator of lipid synthesis discovered in bacteria and is largely conserved in Gram positive organisms. A key intermediate in fatty acid biosynthesis, malonyl-CoA, acts as a negative effector of the transcriptional repressor FapR. We propose to use structural biology, genetic and biophysical approaches to study the molecular mechanisms by which malonyl-CoA modulates the DNA-binding activity of FapR.The detailed understanding of this modulation mechanism will provide unique opportunities to learn how Gram-positive bacteria monitor the status of fatty acid biosynthesis and adjust the lipid synthesis accordingly. The major goal of this project is to carry out structural and biochemical studies of full-length FapR and its complexes with DNA and malonyl-CoA. Furthermore, as it has been recently shown that mutations disrupting the FapR -malonyl-CoA interaction resulted in a lethal phenotype in B. subtilis, we will also extend these studies to FapR from pathogenic bacteria such as B. anthracis, Staphylococcus aureus and Listeria monocytogenes.This knowledge is expected to provide the bas is for the development of novel antibacterial compounds with potential therapeutic applications. The project is relevant to the specific objectives of the Marie Curie Incoming International Fellowships since a promising young researcher from Argentina will undertake research training in Europe and second, it will allow the development of mutually beneficial research cooperation between Europe and this third country. Moreover, the proposal includes a reintegration phase to assist the fellow to return to her country
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biomathematics Euro Summer School on Dynamical Models for Medicine and Physiology", Urbino, July 2002."' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Dynamical systems constitute a fundamental mathematical and computational framework within which many processes in biomedicine can be described. From tumor growth to hormonal regulation, from the spread of disease to neuronal transmission, the crucial feature of many biological and natural phenomena is their evolution in time. Differential equations are the historically established mathematical tool for the study of dynamical systems; within these, differential equations with delay have recenty emerged as a field rich in applicative possibilities and interesting structural behaviour. Computationaly intensive techniques have also enjoyed in recent years, increasing recognition, in the wake of the more widespread availability of cheap computing power. The possibility of numerically computing solutions for classically posed (but analytically intractable) differential models has made it possible to identify their parameters from observational and experimental data, providing the medical practitioners with estimates of the quantities most directly useful to them (like the transfer rates of substances between different body compartments).This evolution has even prompted the re-framing of some medical problems in terms of the results of specific model fits to standardised experimental data. With steeply increasing medical care costs, advancing diagnostic technology and heightened expectations from the community, mathematical modellers will find more and more occasions to work in the medical field. The biomathematics looking for exposure to medical problems and to young biologists and physicians intending or employ mathematical tools in their research; it intends to focus on the interpay between delay differential equations, computer-intensive methods and parameter estimation i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Straintronic control of correlations in twisted van der Waals heterostructures' under Horizon Europe.

assistant: **Concept**

Correlations and topology are the cornerstones of modern condensed matter physics, and their coexistence is believed to lead to novel quantum electronic devices with built-in information protection.  In the landmark discoveries of previous years it has been found that in 2D materials placed on top of each other at a magic rotation angle, correlated phases appear. In contrast to high-Tc materials, in twisted van der Waals materials correlation effects are coupled with topology and thanks to their gate tuneability the exploration of their phase diagram takes only days instead of years. This has led to the discovery of a multitude of correlated phases including correlated insulators, orbital magnetic, non-conventional superconducting and ferroelectric phases, etc. Despite the immense interest, the understanding of their behaviour at the microscopic level is limited, which calls for further experiments and novel experimental tools.In this project we will implement techniques that are radically new in this field: hydrostatic pressure and mechanical strain to uncover the ground state properties of twisted graphene and transition metal dichalcogenide heterostructures. Since the interlayer coupling plays the dominant role, changing the distance of the layers with hydrostatic pressure has a dramatic effect on the band structure and the correlated phases that emerge.  The symmetries of the system can be deterministically broken by strain patterns applied in-situ. This very timely project will lead to several breakthroughs including a) revealing the ground state of twisted bilayer graphene at different filling factors from the large set of competing phases, b)  in-situ engineering of the topology of these systems, or c)  tuning quantum phase transition between non-Fermi liquid pha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Writing on the Margins: Graffiti in Italy (7th–16th centuries)' (Graff-IT), addressing dissemination and exploitation.

assistant: **Impact**

In all modern languages, the word ‘graffiti’ is associated with social criticism, protest movements and vandalism. On the contrary, what historians call graffiti is unrelated to transgression. Nonetheless, contemporary and ancient graffiti share one important aspect: both are public writings, produced spontaneously and beyond any control from authorities. Graffiti give us access to the worldview of individuals in the past: this is why they are an important historical source, worthy of being considered, alongside the conventional sources.The Graff-IT project aims to develop a new interdisciplinary approach to the study of medieval and Renaissance graffiti (7th-16th c.) as a historical source, in order to allow a correct contextualization of graffiti within their space-time and social production frame. The project will focus on the following objectives: 1) Giving graffiti full dignity as a written source and asserting the study of graffiti as intrinsic to palaeography; 2) Overcoming the atomistic approach to graffiti, in order to identify new textualities and new languages; 3) Reading graffiti as a source for the history of devotional practices; 4) Interpreting graffiti as signs of the socio-cultural identity of people and places; 5) Exploring graffiti to change our perception of historical artworks, shifting the focus from the creation stage to its social function and use over time.The project will have an innovative and groundbreaking effect on the established method of historical investigation: different perspectives will merge towards an integrated approach that takes the multifaceted complexity of graffiti (writing, image, language, and material aspects) into account. Innovative tools and methods will be used to build out the first national graffiti survey and the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of animals in the Arab aGricultural Revolution in Al-Siqilliyya. The introduction of new sheep husbandry practices and breeds, and the spread of Arab culture into medieval Sicily.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Animal husbandry has been a core productive area of the European economy since the introduction of domestic animals during the Neolithic. In today's geopolitical scenario, past husbandry regimes can provide essential insights into improving the resilience of animal production, adapting to local resource availability while maximising yields. The research context of this project is medieval Sicily. Located in the centre of the Mediterranean, Sicily has always been a melting pot of different cultures; the clear affirmation of Byzantine, Arab, and Norman/Swabian rules during the Middle Ages entailed the development of distinct socio-cultural and economic models, each influenced by and adapted from previous practices. This makes Sicily a primary case-study for the understanding of the integration of different cultures and the impact of different politico-economic systems. Between the 7th and the 13th c. AD, the Mediterranean Basin witnessed an important transformation in landscape use and its management defined in the 1970s as ‘the Arab agricultural Revolution’. This concept has been revised and nuanced since, and it was probably a more gradual process than initially thought. In contrast to other materials, animal bones and teeth have been overlooked, despite they provide direct evidence of dietary habits, landscape management strategies, and economic dynamics of the past. Preliminary research suggests that the Arabs managed to produce bigger animals (and thus higher meat yields) across the Mediterranean, but how? For the first time, AGRAS will develop a multidisciplinary research combining traditional archaeozoology, collagen fingerprinting (ZooMS), isotopes (oxygen, strontium, carbon and nitrogen), dental meso and microwear to understand the reasons enabling Arabs to produ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MOF and COF hybrid ultrathin films: A surface templated and scanning probe nanolithography approach' in the context of a Horizon Europe call.

assistant: **Objectives**

Single organic molecules can be joined together to form extended frameworks. Materials that use metal-ligand coordination or direct covalent bonding as the ‘glue’ between organic subunits, termed metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), respectively, are being developed for a huge variety of applications. Hybrid materials, containing two, or in some cases more, distinct types of MOF and COF often have an observed enhancement in their properties compared with the constituent pristine MOF and COF materials. Thin films of MOFs and COFs have emerged as promising materials for incorporation into electronic devices, such as transistors and detectors. It could be envisaged that in a similar manner to the bulk materials, hybrid thin films containing multiple distinct types of MOF and COF could provide a route to improving the performance of already promising MOF and COF thin films.Instead of layering the different materials on top of one another (z-direction), here it is proposed that mixing the materials in the plane of growth (x/y plane) would enable the increase in the number of constituent MOFs and/or COFs without increasing the film thickness. The proposed project aims to pioneer methodologies to prepare such hybrid ultrathin films. In the first instance, scanning probe nanolithography will underpin the approach. Regions with diameters of up to 100 nm will be etched into surface mounted MOF or COF ultrathin films, followed by the formation of distinct COF and/or MOF types within these confined spaces. When the hybrid films have been thoroughly characterized by scanning probe microscopy and the processes by which they assemble have been established, a more scalable synthetic strategy to fabricate the materials will be developed. An approach wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mathematical modelling of fracture in adhesive joints' (MATHMOD).

assistant: **Concept**

Composite elastic materials are widely used in modem technology, especially in aircraft industry and civil engineering. Such materials exhibit variety of physical/chemical features and have special mechanical properties. Defects appearing during manufactur ing processes and exploitation reduce the strength of the composites and can even lead to a catastrophic failure. There are many investigations concerning the interaction between defects with bi-material interfaces in composites working under different loa ding conditions. However, most of them have been based on the classical transmission conditions (or ideal contact), which are not able to take into account fields of high gradients within the bonding region at the interface. In the proposed project we are planning to develop mathematical models for the so-called imperfect transmission conditions between the different materials. Recently, new results in this direction have been independently obtained by the Partner leader, Prof. G. Mishuris, and the proposer , Prof. A.B. Movchan. The results showed that, in some specific cases, behaviour of composite with defects depends strongly on properties of the interface. The plan of our work includes analysis of Wiener-Hopf problems associated with 3-D cracks on the int erfaces appearing in modellin of the crack propagation. And finally we will analyse various spectral problems for periodic composites with perfect and imperfect material bonding where each cell contains a crack. Such problems are important for the non-dest ructive control and for the analysis of stop bands for waves of acoustic frequencies within composite structures. All corresponding boundary value problems in combined domains with non-classical transmission conditions will be solved by reduction to bounda ry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultra thin chip integration process for low cost communicative polymer foils' under Seventh Framework.

assistant: **Concept**

Chip2Foil aims at realising a technology platform for low cost placement and interconnection of ultra thin chips on polymer foils, within a high volume, reel-to-reel production concept. This competence allows realising a broad variety of disposable communicative packages. These packages provide increased interaction between the packed product, the package and the user through near-field communication systems, allowing improved intelligent control of the logistic process of high volume applications like medicine and food. The chosen demonstrator is a Smart Blister package, which monitors the medicine taking behaviour of patients to ensure therapy compliance. Therapy non-compliance is a severe ethical and economic problem, leading to considerable numbers of casualties per year and high health care cost.<br/>A breakthrough is needed to raise the throughput of ultra thin chip placement and interconnection while reducing the cost. Target values are: chip thickness 10-20µm, 10-50 chips/second, package thickness 30-50µm, and assembly cost reduction 50%.<br/>The proposed Chip2Foil technical concept combines two main elements: (1) self-assembly for high speed chip placement with moderate accuracy, and (2) an adaptive circuitry approach, which compensates the initial placement errors and creates electrical interconnects after the chips have been placed.<br/>The objectives of Chip2Foil are to develop the main technology building blocks for the self-assembly and the adaptive circuitry approach, to determine and evaluate a preferred integration of these techniques, and to demonstrate and evaluate a complete process flow by realising a communicative foil package for the Smart Blister application.<br/>The consortium of 7 partners (4 industrial of which 1 global end-user, 2 research ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Atmospheric nucleation: from molecular to global scale' in the context of a Seventh Framework call.

assistant: **Objectives**

Atmospheric aerosol particles and trace gases affect the quality of our life in many ways (e.g. health effects, changes in climate and hydrological cycle). Trace gases and atmospheric aerosols are tightly connected via physical, chemical, meteorological and biological processes occurring in the atmosphere and at the atmosphere-biosphere interface. One important phenomenon is atmospheric aerosol formation, which involves the production of nanometer-size particles by nucleation and their growth to detectable sizes.  The main scientific objectives of this project are 1) to quantify the mechanisms responsible for atmospheric new particle formation and 2) to find out how important this process is for the behaviour of the global aerosol system and, ultimately, for the whole climate system.  Our scientific plan is designed as a research chain that aims to advance our understanding of climate and air quality through a series of connected activities. We start from molecular simulations and laboratory measurements to understand nucleation and aerosol thermodynamic processes. We measure nanoparticles and atmospheric clusters at 15-20 sites all around the world using state of the art instrumentation and study feedbacks and interactions between climate and biosphere. With these atmospheric boundary layer studies we form a link to regional-scale processes and further to global-scale phenomena. In order to be able to simulate global climate and air quality, the most recent progress on this chain of processes must be compiled, integrated and implemented in Climate Change and Air Quality numerical models via novel parameterizations.