RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Population genetic modelling and analysis of HIV transmission histories' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We propose to develop a model that unites viral population genetics and phylogenetics to investigate HIV transmission histories. This genealogy-based population genetic model will accommodate for variable population sizes within and between infected hosts, while taking into account phylogenetic relationships between the patients.It is our objective to implement this model in a recently developed, highly flexible Bayesian framework and to validate this method on a comprehensive set of clonal sequences sampled over time from a well-documented HIV transmission chain. We aim to apply our novel approach to at least three well-characterized HIV transmission chains and to extend the application to other rapidly evolving virus populations.This will allow us to estimate the strength and magnitude of the genetic bottleneck associated with viral transmission and to evaluate its impact on evolution at the population level. Thereby, we can address the switching of co-receptor usage within patients and the spread of immune-escape and drug resistance mutations in the HIV infected population. This research will also result in statistical methods that provide a more realistic description of viral evolution with important practical applications in viral epidemiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Polymer pRobes fOr a VISual prOsthesis' (PROVISO).

assistant: **Concept**

Approximately forty million people across the world are blind, a condition with serious consequences for a persons autonomy. Restoration of visual function in blind individuals is an important scientific goal with large societal benefits. In a large fraction of blind patients, the connection between the eye and the brain has degenerated so that restoration of a rudimentary form of vision can only be achieved in pathways downstream from the retina, like the visual cortex. PROVISO tests the feasibility of a new approach for a cortical visual prosthesis by implanting flexible polymer electrodes into the visual cortex that can be stimulated electrically to create a rudimentary form of vision. Weak electrical currents applied to an electrode in the visual cortex induce an artificial percept of light, called phosphene. Multiple phosphenes can be used to build up a shape, just as the lights of a matrix board along the highway generate letters. A promising approach to restore vision involves inserting tiny electrodes into the visual cortex, close to the neurons, so that weak currents result in phosphene perception. There are two problems that need to be solved before the prosthesis can become a treatment for blind individuals. The first problem is that the electrodes available for chronic implantation are made of silicon or metal, which causes a tissue response (gliosis) causing the interface with the tissue to degrade after several months. The second problem is coverage of the visual field. In humans, much of primary visual cortex (V1) is not located on the surface of the brain, but inside a sulcus, making it difficult to access. PROVISO will develop methods to implant flexible electrodes, that cause little tissue damage and remain functional across longer time scales, into th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis and segmentation of remote-sensing images for land-cover mapping' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The objective of the proposed project is to develop a robust and sufficiently accurate method for the segmentation, classification and change detection of remotely sensed data for land-cover mapping. The project will be carried out in cooperation with the host institute and with an industry that has strong links with end-users of remote-sensing data. Special emphasis will be placed on two aspects: 1. a methodology to assess the quality of segmentation, classification and change-detection methods; 2. the systematic development of the aforesaid methods which should be more cost-effective than existing methods. Innovative aspects are: 1. explicit definition of quality measures in cooperation with industry; 2. extensive use of different types of information present in data; 3. high accuracy according to defined quality standards; 4. high levels of user-friendliness and robustness provided by the automatic estimation of processing parameters that will aid a future implementation in geographical information systems.//ORLhttp://dibe.unige.it/tmr_smits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of the dopamine system in human reinforcement learning' (DOPAMINE).

assistant: **Innovation**

Animal research has indicated an important role for the ventral tegmental area (VTA) and its neurotransmitter dopamine in reinforcement learning, an elementary form of learning on the basis of rewards and punishments. In recent years, cognitive neuroscientists have used these animal data to develop various highly sophisticated theories on the role of the dopamine system in human reinforcement learning. However, crucial empirical tests of these theories in human subjects have generally been lacking, probably in part because of the considerable methodological challenges involved. The goal of the proposed research program is to address these challenges using a number of novel methods: (i) High-field (7 Tesla) functional magnetic resonance imaging in combination with a set of recently published acquisition and analysis methods will allow us to directly measure activity of the VTA; and (ii) pharmacological magnetic resonance imaging will allow us to investigate the effects of experimental manipulations of the dopamine system on brain function and behavior. We will use these methods to test detailed theoretical predictions regarding the role of the human dopamine system in coding error responses and negative feedback, in learning from positive and negative outcomes, and in valuing immediate versus delayed rewards. The proposed research will be important in elucidating the role of the dopamine system in human reinforcement learning. At the methodological level, it will open the door for the careful study of the role of dopamine in human cognition at large.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ferroelectric CVD layers for memory applications', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The project addresses the proof of an equipment concept suitable of producing ferroelectric layers based on chemical vapor deposition. This concept will be verified using an existing MOCVD reactor which is intended to be upgraded as a production tool for ferroelectric devices on 200mm silicon wafers. The project includes the development of optimised materials and processes to be used in the manufacturing of the new, promising FeRAM devices which are expected to serve as a Universal RAM" since it combines high speed and non-volatility. Moreover, the processes used are designed for cost-effective implementation since they are compatible with existing mainstream silicon technology.OBJECTIVESFerroelectrics are very promising materials for a wide range of microelectronic applications. They can be used as the dielectric layers in universal memory devices (FeRAMs) combining the advantages of the fast but volatile dynamic memories (DRAMs) and non-volatile memories (e.g., EEPROMs). They also simplify the integration of capacitances in high-volume logic devices like telecom devices or chipcards. Alltogether, it is a market of billions of devices in applications for everyone. The project objective is to provide competitive materials, processes, and tools compatible with the specifications of the 0.18?m technology and beyond. The envisaged process sequence will provide improved device performances and will enable simplified devices and printed circuit board architectures.DESCRIPTION OF WORKThe layer properties, process, and the performance of the equipment will be specified based on the inputs from the "users" in the consortium. Focus will be put on the quality of the layers as well as on the durability. The equipment specifications will continuously be assessed with respect to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'All-electrical analytic platform for digital fluidics' (ANALYTICS), addressing dissemination and exploitation.

assistant: **Impact**

Prospective biosensing technologies will need to tackle the grand challenges arising from the global demographic changes. Among the most crucial tasks is the monitoring of food and environmental quality as well as the medical diagnosis. Digital fluidics offers vast advantages in performing these tasks relying on tiny containers with reacting biochemical species and allowing massively parallelized assays and high throughput screening using optical detection approaches. I envision that adding not-optical detectors, which electrically probe the analyte responses, will provide a source of new but complementary information, obtained in a label-free and contactless manner. Hence, these all-electric platforms enable monitoring the kinetics of chemical reactions in lab-on-chip format, as well as take over auxiliary tasks, e.g. indexing, counting of droplets, flow monitoring.In frame of the ERC project SMaRT, my team developed a unique detection platform -millifluidic resonance detector- that inductively couples to an analyte and assesses its physico-chemical properties. The unique selling points are (i) non-invasiveness to analyte, (ii) unnecessity of a transparent fluidic channel, (iii) cost efficiency and (iv) portability. Implementing the input from the partner companies, here I aim to reach the commercialization stage pursuing a number of key milestones, i.e. enhance the screening throughput, realize a platform independent of external electronic devices, provide a temperature stabilization of the response, and develop the app. Societal benefits: We demonstrated that the device provides an access to the metabolic activity of living organisms in droplets. This is way beyond the capabilities of the state-of-the-art optical detection. With this feature, the device can address t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SpaceSense – Democratizing satellite imagery for Machine learning' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SpaceSense is a French deep-tech Space-AI company, created in 2019. Our mission is to democratise access to intelligence from Earth observation (EO)  technology by making it possible for data scientists to create applications using EO data without the need for expertise in remote-sensing nor any infrastructure investment. With us, our users build an EO product in days instead of months and at 20% of the cost.We are building a platform to simplify end-to-end “Data preparation” for satellite imagery - AI solutions. We have released a first version of the platform earlier this year that allows a user to access different types of satellite imagery (Sentinel-1 & Sentinel-2)  in an “Analysis ready data'' format, combine it with weather data, add various proprietary datasets like drone, sensor data, or other geolocated data & generate a clean feature-cube compatible with tensorflow/pytorch models to create practical solutions and at scale thanks to SpaceSense’s compute engine- a proprietary system fine-tuned to perform large scale on-demand EO data analysis on cloud. We have ongoing pilots & trials with the first release of the platform.Through Women Tech EU, we aim to develop a core technical component of “Data preparation for AI” capabilities to help us create a clear competitive advantage to achieve product-market fit in 2024, and set up the processes for a more diverse and gender balanced workplace as we grow our team.This will be achieved through four main tasks, detailed in the proposal:- Data Augmentation tool for Sentinel-2 imagery- Creation of “Solution template”- Marketing and sales - HR tools & processesJyotsna Budideti is the co-founder and CEO of the company. She has been driving the company’s vision and strategy. On a day-to-day basis she leads the product develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Knowledge Juicer: Readers get Superpowers' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Content production has increased significantly over the past few decades, both in the public and private sector, driven mostly by the digitization process. Kjuicer is a project that aims at closing the gap between production of written content and our ability to read it. In the past few decades such gap has grown dramatically: estimates run that every day 5 million new articles get published in cyberspace. Kjuicer is a flexible and customizable, deeply user-oriented curation tool. It allows extraction of contents in an innovative way, using highlighting colors hierarchically, yet maintaining completeness of meaning. Through a specific algorithm that scans the content's meta-data, it leverages the user’s highlights to synthesize and organize a text respecting the original version. It then makes multiple versions of it, organized in order of importance, and turns it into a browsable and zoomable resource. Kjuicer offers a potentially disruptive innovation for texts, i.e. a solution to augment reading capabilities. It provides a pre-production service (Editor + Plug-in) and a post-production service (Suite), the first being targeted at creating native content, the second at curating existing documents or web pages. The ever increasing complexity of our world poses knowledge challenges at all levels: from kids in school who are being asked to learn better and more, on more subjects, up to professionals who are competing based on knowledge and ability to handle complex projects. Kjuicer helps also Public Administrations and Large Private/Public Companies that need to increase communicative effectiveness. The product will boost growth of the company, generating over 16M€ cumulated revenues in 5 years and creating 24 new jobs. The total financial requirement amounts to about 1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wnt agonist Dickkopf 3 (DKK3) is a type 2 diabetes susceptibility gene' (DKK3), addressing dissemination and exploitation.

assistant: **Impact**

Type 2 diabetes mellitus (T2DM) is a complex genetic disorder of largely obscure etiology where alleles at numerous loci are thought to interact with environmental and stochastic cues to induce the phenotype. We have recently identified a T2DM susceptibility allele at the DKK3 locus. Using a combination of case/control association and functional studies, we demonstrated that the minor allele of SNP rs11022111 in the DKK3 promoter is significantly associated with T2DM in two Chinese and one Caucasian cohort and results in the disruption of a conserved SP1 binding site, leading to reduced DKK3 expression. We also showed that, in contrast to other members of the DKK family, DKK3 is a likely agonist of Wnt signaling (both canonical and non-canonical), in a Fz- and LRP6-dependent manner and regulates the expression of TCF7L2, another T2DM susceptibility gene. Our preliminary data implicate the regulation of Wnt signaling in the pathogenesis of T2DM. In this proposal, we hypothesize that aberrant Wnt signaling in the adult pancreas can lead to impaired glucose tolerance, insulin secretion and other diabetic phenotypes. To address how Dickkopf 3 influences Wnt signaling in β-cells and pancreatic islets as well as pancreatic islet functions, I propose to identify the subset of Wnt signaling components that are active in MIN6 cells and islets, to characterize the effect of impaired Wnt signaling on islet function and formation, and finally, to investigate the metabolic state of Dkk3-/- mice when challenged with a high fat diet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Treasures from the sea - a 52-minute international tv-documentary/ video for educational purposes and web site about marine bioprospecting' (TREATS).

assistant: **Innovation**

TREATS are a packet ofa) a TV documentary/video for the general public,b) a multimedia web-site, both about marine bio prospecting. The documentary will tell the story about the search for new drugs in marine organisms. This will be done through reports from research projects in Europe, USA and the Philippines, covering different aspects of the field, weaved into one story. The aim is to create interest among the broad public, especially young people. Videos and a teachers' guide will be distributed and made freely available to educational inst. within EU. The web site will give additional information, especial lee for in depth exploring in education, and for those who might think of this as a career. Both media products will be produced at the University Media Centre in Bergen and produced in all 11 EU languages + Norwegian. The work will be done in cooperation with leading international scientists in the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Elucidating the underwater adhesion of the brown algae Fucus vesiculosus' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Many marine organisms of the intertidal zone like mussels, barnacles and various algae must form strong attachments to the substrate in their environment in order to resist forces of crashing waves. Therefore, they evolved high-performance underwater adhesives which are able to stick to various surface chemistries - a feat unmatched by current glues on the market. Understanding the chemistry and formation process of these adhesives has great potential for the development of synthetic underwater glues which are of high interest for medical and industrial applications. Here, I propose to conduct research on the underwater adhesion of the brown macroalgae Fucus vesiculosus analyzing its composition, structure and adhesive properties. For this purpose, the early formation process shortly after the fertilization of Fucus egg cells will be analyzed using a combination of traditional histology and advanced electron microscopic and spectroscopic techniques. Once key building blocks have been identified, their dynamic secretion and assembly process will be followed over time. Additionally, the curing of the adhesive and the involved crosslinking reactions will be investigated after different time points. Elucidating key chemical principles of the complex formation of this underwater adhesive has the potential to inspire the development of novel and sustainable adhesives with a wide range of applications.


**Keywords:** Adhesion,  Underwater adhesives,  Polyphenols