RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Center for Ethics in Public Affairs' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

ETICA, Center for Ethics in Public Affairs at the American University of Armenia, under the direction of ERA Chair Professor Maria Baghramian, will become a national hub for analysing and researching key ethical issues in the public sphere. ETICA will carry out its activities under the four pillars of Research and Internationalisation, Training and Capacity Building, Outreach and Public Engagement, and Structural Reform, focusing on the following objectives: to internationalise research through a collaborative research project on Trust and Hope in a Time of Poly-crises; to create long-term research and training resources in ethics in public affairs; to offer training opportunities in professional, applied and research ethics; to engage the public in participatory deliberations on key ethical issues; to generate policy briefs informed by its theoretical, empirical and participatory findings; to encourage reform in research management at institutional and sectoral levels; and to assist in strengthening international research funding applications. ETICA will have a lasting impact on the development of research and training in public ethics in a small country with limited resources. By recruiting an excellent team of researchers, the Center will also contribute to revitalizing research and publication in the humanities. Through its training and capacity building activities, ETICA will promote the development of codes of professional conduct in research and governance. By engaging with the general public, in the course of town halls, youth juries and deliberative mini publics, ETICA will strengthen the practice of open and reasoned discourse on issues of public significance in a post-Soviet country steadily moving towards democratisation. ETICA will introduce changes in rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Macromolecular Voltage-Gated Na+ Channel Complexes in the Regulation of Normal and Diseased Cardiac Excitability'.

assistant: **Objectives**

The dynamic modulation of ion channels is crucial to the regulation of cardiac excitability and defects in channel modulation, associated with congenital and acquired cardiac diseases, lead to the development of life threatening arrhythmias. The dynamic modulation of functional expression of ion channels is achieved through changes in cell surface expression and/or functioning of pore-forming channel subunits. Some of the mechanisms used to achieve these regulations involve interactions of pore-forming channel subunits with accessory subunits and post-translational modifications (PTM) of channel components. The voltage-gated Na+ (Nav) current (INa), generated by Nav1.5 channels, is a key regulator of cardiac excitability, modulating action potential waveforms, refractoriness and propagation. Previous studies have linked family mutations in genes encoding Nav1.5 and Nav1.5 interacting proteins with cardiac arrhythmias, and parallel analyses have suggested roles for these mutations in dysregulating Nav1.5 channel functional expression. However, the mechanisms whereby such native alterations in Nav1.5 function are achieved require identification and functional analysis of in situ Nav1.5 channels. The goal of the present proposal, therefore, is (1) to characterize the native components of Nav1.5 channel complexes, as well as PTM of these components, in the heart, by the use of mass spectrometry analyses; (2) to investigate the role(s) of the previously identified accessory subunit ankyrin G in regulating the functional expression of Nav1.5-encoded INa channels; and (3) to analyze the regulation defects associated with the E1053K mutation in Nav1.5, associated with Brugada syndrome, at the molecular, cellular and whole-animal levels. Altogether, the research proposed will im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'From Fermat's principle to quantum teleportation'.

assistant: **Concept**

The project deals with the historical roots of wave mechanics; with some of its foundational peculiarities,especially entanglement; and with consequences, some practical, of that entanglement. The peculiarities in question did not come out of nowhere; they were the outcome of a long and natural evolution. I derive wave mechanics and the Schrödinger equation from a historical programme¿whose (largely unattained) goal was to \'bring together matter and light\'¿rather than from logical requirements, as has oft en been attempted in the quantum logic programme. I point out that matter and light were seen as fundamental constituents (in one or more appropriate senses) of the world, suggest it was appropriate to bring them together, and show how it was that a natur al, perhaps even inevitable synthesis of staple classical theories led to the entangled wavefunctions of wave mechanics¿and hence to quantum teleportation and so many other surprising possibilities¿which seriously undermine the world view to which those cl assical theories belonged (an interesting historical paradox in itself). I propose the first set-theoretical characterization of Hamilton-Jacobi theory and the optico-mechanical analogy, which had such an important part in the genesis of wave mechanics. T his analogy is usually expressed by describing analytical mechanics and geometrical optics, then pointing out their similarities. I begin with a description of the bare mathematical theory the two theories have in common, and view mechanics and optics as d isjoint classes of models of the common axioms. To bring out the paradoxical character of entanglement, I propose an original approach to Bell\'s inequality: first a purely formal (\'structural\') scheme, in which the inequality is derived and a bare \'q uantum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improving Diagnoses of Mental Retardation in Children in  Central Eastern Europe and Central Asia  through Genetic Characterisation and Bioinformatics/-Statistics,' (CHERISH), addressing dissemination and exploitation.

assistant: **Impact**

Mental retardation (MR) is a highly heterogeneous disorder and is of genetic origin in about 50% of the cases. Despite recent progress in research the causes and the pathophysiology of MR remains obscure. It is essential to investigate this in order to develop future diagnostic and therapeutic strategies. The overall goal of this proposal is to establish an interdisciplinary Eastern Europe and Central Asia (EECA) consortium of experts with a joint programme of activities to generate knowledge about MR and the structure and dynamics of the brain as such. This project will be the first to study in depth the prevalence and incidence of MR in EECA . The objectives of the CHERISH project are to: - to develop a standardized approach for MR diagnosis through clinical workshops and courses - to create a large data-base of patients with clinically well defined MR, both syndromic and non-syndromic - identify cryptic genomic rearrangements through molecular cytogenetic analysis - sequence MR genes and analyse the molecular epidemiology of MR in Eastern European populations - develop diagnostic tools for recurrent/common mutations - identify new MR genes in X-linked and autosomal recessive forms of the disorder - increase awareness on the possible genetic origin of MR and implications for novel therapeutic strategies The project partners will join forces to create a large collection of samples and a database from MR patients which will be become the reference. All institutions involved are the referral centres for MR in their respective countries. The molecular studies will be performed in technologically-advanced genetic laboratories. A straightforward outcome of CHERISH will lay the basis for a significant improvement of clinical, educational and industrial developments. The proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent manufacturing of wood products using colour, X-ray, and computer tomography-based quality control' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

We propose a project to apply Intelligent Manufacturing techniques to design and implement advanced technology for the year 2000 wood manufacturing plants. This projects brings together a consortium of SME's, Universities, and non-SME end-user companies. The goal is to advance the state-of-the-art in the area of automatic quality assurance in present and future wood manufacturing plants. This will result in efficient utilization of wood as a precious raw material, and at the same time reduce production costs through a high degree of automation. Technologically, the target is the development of a comprehensive intelligent on-line quality inspection system using digital color imaging techniques, X-ray imaging, and computer tomography imaging.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exfoliated black phosphorus for biomedical applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Since its discovery in 2014, bidimensional black phosphorus has raised a great scientific attention due to its unique structure and several exceptional attributes, such as peculiar optical and mechanical properties, excellent biocompatibility and biodegradation, which make it particularly attractive for biomedical applications. Our studies performed during ERC-Advanced Grant (2015-2019) “Phosphorene functionalization: a new platform for advanced multifunctional materials - PHOSFUN” demonstrated the possibility to produce at large scale 2D BP with high purity grade at low cost by liquid exfoliation of bulk crystalline BP. In addition to its low toxicity, we have proved that SMART BP treatment, obtained using our proprietary production process, has anti-proliferative effects as well as anti-inflammatory and regenerative properties in prostate tumours that can disrupt the treatment approach. Prostate cancer is the second most common cancer in men worldwide with about 1.3 million cases in 2018 and about 379,000 new deaths are expected by 2040.  This makes prostate cancer a major public health concern. As also stated by the European Urology Association, there is a need for more effective and cheaper early treatment options (alternative to radiotherapy or radical prostatectomy) that can bring a substantial decrease of healthcare costs.Given the positive outcomes of lab tests performed by the PoC team while investigating the application in the health domain, we propose a patented prostate cancer treatment based on few-layer black phosphorus, SMART BP, that is a non-radioactive smart nanomaterial with no side effects (no irradiation, no toxicity, self-regeneration), improving patient’s quality of life and provide considerable economic benefits. Within PHOSMED we intend to valid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International Law and Place' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

International law is increasingly being called upon in response to climate change and environmental harm. International courts and tribunals have been asked by States to clarify State obligations in respect to climate change through advisory proceedings, and human rights treaty bodies and courts are seeing a dramatic proliferation of climate-related litigation and complaints. But how is the discipline of international law equipped to rise to the challenge of our current environmental crisis? This project suggests that an important answer lies in the concept of territory, and the matter of place, under international law. Whilst territory is a foundational concept under international law, it offers a rather sterile understanding of the diverse ways through which we relate to the environment around us. It is a legal abstraction which allows international law to carve up the world into neatly organised unites, and does not account for many of the interdependent relations that communities have to each other and non-human actors in place. This project hence proposes that international lawyers would benefit from the development of place as a conceptual frame in international law, operationalised alongside that of territory. It will trace how international law is engaging with a range of notions of place beyond what arguably is possible within the international law of territory, and how it might be shaping the discipline in unacknowledged ways. The importance of the project lies in its ability to theorise and articulate place as a conceptual frame in international law, and articulate how it can enable more precise and robust State obligations relating to climate change and environmental harm. It will contribute to the theoretical and doctrinal debates that international courts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-Agent Systems for Pervasive Artificial Intelligence for assisting Humans in Modular Production Environments' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

European industry has been very competitive on the global markets by utilizing highly efficient Artificial Intelligence (AI) tools and massively producing high quality products. The advent for mass customization has been stressing the capability of modularization and flexibility of production processes through the incorporation of AI technologies. However, the communication between the different automation systems has not been yet accomplished efficiently since they lack interoperability and are restricted to their own system of coordination. The MAS4AI proposal proposes a system that allows the deployment and synchronization of different AI agents in manufacturing for autonomous modular production and human assistance. The MAS4AI system will be heavily driven by large industrial cases and will aim towards digitalising European industry with AI tools according to the Industry 4.0 paradigm. MAS4AI will develop its overall ambition by the means of four Scientific and Technological objectives namely: a) Multi-Agents-System (MAS) for distributing AI components in different hierarchy layers, customers and suppliers for realising refurbishment activities, b) AI agents using Knowledge-based Representation with Semantic Web Technologies, c) AI Agents for hierarchical planning of production processes, d) model-based Machine Learning (ML) AI agent. MAS4AI research and technological activity will be strongly driven by a set of industrial use cases which will be then used as demonstrators. The demonstrators involve important industrial sectors of high value added for Europe, namely AI technologies used for automotive, contract manufacturing, bicycle industry, bearings production and wood processing industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bog Ecosystem Research Initiative' (BERI).

assistant: **Innovation**

To experimentally enrich with CO2 and N representative peatmoss bog ecosystems at five climatically different sites across Europe, with the aim to study the effects of elevated CO2 and D deposition on the net exchange of C gases (CO2 and CH4) between bogs and the atmosphere. - To study the effects of elevated CO2 and N deposition on the plant biodiversity of bog communities. - To quantify impacts of elevated CO2 and N, specifically:  (1) on the population dynamics of different species of peatmoss and selected vascular plants  (2) on the growth of dominant species in the bog ecosystem  (3) on the organochemical and structural properties of dominant mire plants  (4) on the decomposability of litter from mire plants  (5) on the emission of CH4 from the bogs. - To develop process-oriented models that describe responses of botanical composition, C-sequestration and CH4 emission in bogs in Europe in response to changes in atmospheric CO2, N deposition and climate.Northern oligotrophic peatlands are important for the exchange of greenhouse gases between land and  atmosphere. They (1) contain 25 % of the world's soil organic carbon, (2) may constitute a nearly continuous  sink of atmospheric CO2, and (3) emit appreciable amounts of atmospheric CH4. Increasing atmospheric CO2  and deposition of N will change the net exchange of those greenhouse gases and peat bogs, through effects of  elevated CO2 and N on (1) productivity and chemical composition of bog plants and (2) the competitive balance  between bog plants (esp. peat mosses versus vascular plants) with different peat forming properties and substrate  qualities for methanogenesis.  It will employ 5-replicated MiniFACE (Free Air Carbondioxide exposure) systems at six sites along the main  climatic and N-deposition gradients
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of the most effective tools to control infectious diseases in animals'.

assistant: **Objectives**

DISCONTOOLS will provide a mechanism for focusing and prioritising research that ultimately delivers new and improved vaccines, pharmaceuticals and diagnostic tests. The project will make a major contribution to the objectives of the relevant FP7 call. There are three complimentary work strands backed up by the development of a comprehensive communication strategy.     The first strand will provide a validated database and peer reviewed methodology in order to prioritise infectious animal diseases. Gap analysis is the second strand and will be carried out to identify those areas where information and knowledge of the disease is deficient and where current tools are lacking, inadequate or could be improved. Information will be collected in a standard format for validation and entry into a specific disease database. A detailed analysis will then be carried out for each of the priority diseases to identify gaps in key areas.   The third strand is to identify current and new technological tools that may be used to improve the ability to control infectious animal diseases. The work will include review of existing arrangements by stakeholders and the development of methodologies to identify and evaluate new technology. Effective identification and technology transfer is essential if new tools for disease control are to be developed  One of the main features of the project is the involvement of a wide range of stakeholders who will actively participate in the governance of the project. This will ensure that the stakeholders involved from research through to delivery of new control tools will be able to contribute to the project. Dissemination of information from all three strands of work will be essential if the project is to be successful. This will be achieved through the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pharmacodynamic Approaches to Demonstration of Disease-Modification in Huntington’s Disease by SEN0014196' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Consortium will undertake clinical research activities aimed at ascertaining feasibility of a range of pharmacodynamic readouts for use in the clinical development of SEN0014196 to demonstrate the disease-modifying properties of the compound in Huntington’s Disease. SEN0014196 is a novel and selective SirT1 inhibitor, currently in Phase I clinical development, and enjoys Orphan Status in the EU as of September 2, 2009. A multi-factorial approach will be used, including assessment of both novel and compound-specific measures of molecular action as well as previously identified predictors of disease progression. The translational approaches addressed by this project are instrumental in the progression of SEN0014196 to clinical proof-of-concept and, if successful, will play a pivotal role in patient stratification and outcomes research. The Consortium will comprise four partners, all with a proven track-record in Research and Development in the Huntington’s Disease area. All Partners are based within the EU.