RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a specialised software environment for the design of standard total hip replacement' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The present proposal describes a TRIAL take-up action intended to transfer a set of leading edge computational technologies from the technology Owners (B3C and IOR) to the technology user (AET). AET software house intends to use them to develop a distributed system to support the design of joint prostheses. B3C, IOR and AET will collaborate with two perspective customers (Cremascoli Ortho and HitMedica) to evaluate these technologies in the specific application context: the design of standard joint implants. Standard joint prostheses are supposed to fit reasonably well into any normal anatomy. These devices are currently designed based on experience and with reference to average anatomies. From the end user point view the application developed in this action will improve the design of standard implant providing quantitative feed backs indicating the implant fitting into a large data base of real human anatomies CT data sets.Objectives:The project aim is to adapt the software components developed by IOR and B3C to build up a simulation environment supporting and improving the design of standard joint implants. The system will be composed by a 3D navigational environment allowing the designers to position their implant design in a reference anatomy represented by the CT data set. Once the bone-implant position is defined, an automatic procedure, running on a remote HPC facility would automatically fit" the implant design into a database of human bones CT data sets. For each bone in the database, the procedure will calculate a set of indicators summarised in a synthetic report that will be used by the designer to evaluate its design on a statistical basis. The system should be easy to integrate with the commercial CAD software currently used by prostheses manufacturers.Wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The implementation of Digital Mobile Mental Health in clinical care pathways:  Towards person-centered care in psychiatry' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The overarching aim of IMMERSE (Implementing Mobile MEntal health Recording Strategy for Europe) is to advance the transformation of mental health care in Europe intro true person-centered care, focused on the needs of each individual seeking help for mental health problems, while giving them an active role in their treatment process and decision-making. In order to do so, IMMERSE hasidentified the Experience Sampling Methodology (ESM), a structured diary technique, as the methodology that puts the service user at the heart of their treatment. IMMERSE will integrate 20 years of research evidence on ESM into an innovative, clinical digital health tool, Digital Mobile Mental Health (DMMH), in close collaboration with stakeholders and extending it with mobile sensing data and innovative machine learning models. DMMH consists of an ESM app, assessing self-reports of mental state in daily life, a data-platform that allows the analysis of these data, and dashboard for visualization and feedback. IMMERSE will thoroughly evaluate strategies, processes and outcomes of DMMH implementation at 8 sites in 4 countries in Europe representing different contexts for implementation evaluation. At the same time, IMMERSE will identify and overcome key barriers and strengthen facilitators for implementation, transfer and scale-up of DMMH to routine mental health clinical practice  by closely collaborating with relevant stakeholders, aligning the innovative DMMH tool to their needs. Similarly, the diverse ethical, legal and policy challenges and requirements will be identified and DMMH will be developed and implemented accordingly. Finally, IMMERSE is set out to do a cost-benefit analysis of the implementation and present a framework for future implementation of DMMH, including forecasting s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and evaluation of procedures for the resolution of environmental disputes.' (1994-1998).

assistant: **Concept**

To develop conflict management procedures aimed at the effective regulation of environmental disputes; to analyse and evaluate procedures, with respect to processes and outcomes, in terms of effectiveness and efficiency.OBJECTIVES: To develop conflict management procedures aimed at the effective regulation of environmental disputes; to analyse and evaluate procedures, with respect to processes and outcomes, in terms of effectiveness and efficiency. DESCRIPTION: The project characterises environmental conflicts in terms of the following dimensions: the level of conflict; the relationship and characteristics of the parties; the number and interdependence of the issues involved; the social environment in which the conflict takes place; the nature of the audiences to the conflict; and, consequences having the potential to influence the course of the dispute defined as cooperative, escalating and/or destructive or deadlocked. The project assesses the efficacy and perceived validity of existing conflict resolution procedures in terms of this characterisation. For example, public enquiries, meetings etc., are compared across different settings such as toxic waste incineration or oil refineries in Belgium, Germany and the UK in both urban and rural environments. The project also assesses the utility and validity of incorporating public values into the procedures as quantified trade-off judgements reflecting constituencies of interest. It examines how the most effective procedures fit in with current EU policy in the sectors under analysis. Several methods of data collection are used. Exploratory and relatively unconstrained discussions and interviews are used to select case studies and the management procedures are tested in each setting using before and after measures. Experim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Transitions to adulthood in a context of migration: From unaccompanied minors in Scandinavia to refuge seeking young adults in France'.

assistant: **Concept**

Discussions about migration, integration and unaccompanied minors figure prominently across Europe in public discourse and at policy level. Thousands of unaccompanied minors arrive in Europe each year. Many are granted temporary or permanent permission to stay, yet little research has focused on their transitions to adulthood. ComAge’s scientific significance lies in its aim to contribute to address this gap through investigating unaccompanied minors’ social and legal transitions to adulthood as affected by structural implications, imaginaries, and relational aspects. This is of relevance to support further research on the topic, and for European policymakers and practitioners to respond to the needs and situations unaccompanied minors experience upon their arrival and stay. Young Afghans are a timely and relevant case study to investigate transitions to adulthood as they are the largest group of unaccompanied minors claiming asylum in Europe each year since 2008. To investigate transitions as affected by the ‘return turn’, i.e., increased use of temporary protection and focus on return, participants will be recruited among young Afghans who arrived in Scandinavia as minors and left for France to avoid forced removal as they approach legal adulthood. ComAge is an ethnographic study drawing on in-depth interviews, participant/observation and creative co-articulations as a bottom-up approach that tunes into different forms, layers and modes of expression. ComAge builds on the experienced researcher’s previous research on young Afghans’ journeys to Europe and the implications of age and social relations on their trajectories.


**Keywords:** Afghans, legal and social adulthood, precarious inclusion, temporary protection, creative co-articulations, methods, ‘return turn’, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NMR detected nanosecond to microsecond dynamics for biomolecular recognition dynamics' to be submitted under Seventh Framework.

assistant: **Abstract**

NMR spectroscopy detects in a unique way with atomic resolution biomolecular dynamics in the previously hidden time range between approximately 5 nano- to 50 microseconds (ns-ms time range). The detection of this motion happens in equilibrium under physiological conditions without the need for a triggering reaction. On the example of ubiquitin, this dynamics was found by us to be important for molecular recognition between proteins implying conformational selection rather than induced fit. Only free solution ensembles including this dynamics accessed the full conformational heterogeneity of structures in recognition complexes. Molecular dynamics analysis suggests high correlation of these ns-ms dynamical modes. Here, we propose to establish with NMR experimentally the correlated nature of the ns-ms dynamics, to describe ensembles reflecting ns-ms and sub-ns dynamics by separating the time scales. In this context, using temperature jump-infra-red spectroscopy and solid state NMR we want to determine the time scale of the ns to ms motion more precisely. Since the ns-ms time scale is slower than diffusion, dynamics on this time scale could be a mechanism of regulating or limiting the kinetics of molecular association and recognition. Therefore, we want to determine on-rates by NMR spectroscopy and want to explore whether mutants that do not affect the binding interface but will affect the dynamics modulate the on-rates. This would allow the control of binding kinetics and explore the influence of ns-¼s dynamics on protein-protein recognition on the long run also for membrane proteins. In addition  specificity for drug interactions could be increased addressing extremal conformations present in the ns-¼s ensembles for homologous proteins with otherwise very similar average
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dementia/Alzheimer Drug Attributed to Cystatin-C and other mutations – precision medicine drug development' (DNACA).

assistant: **Innovation**

With an aging population and >55 million dementia cases worldwide; treatments are more needed than ever. However, effective treatments are lacking, with solutions only stalling dementia progress and no real disease-modifying effect. ATI has developed AT-001, a new drug with the potential to stop and revert the disease, and to delay its onset. AT-001 has been developed through the DNACA precision-medicine based platform, which applies Big Data mining and Deep Learning/AI algorithms to identify patients with validated biomarkers. AT-001 is different in that it prevents aggregation of amyloid/tau proteins, common in many types of dementia. Phase IIa clinical trials have shown strong effects in the treatment of HCCAA. We will now carry out a registration trial for commercialization in Iceland and POC studies in Europe to obtain NDA in familial dementia, thereby informing the treatment of Alzheimer’s Disease (60% of dementia cases), potentially changing the lives of millions for the better.


**Keywords:** Precision medicine, big data,therapy,genomics,genetics, dementia,Alzheimer's disease,hereditary cerebral amyloid angiopathies,drug development,biobank
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Scalable Exhibtion Server'.

assistant: **Innovation**

SCALEX is an application server for the publishing of digital content in exhibitions, museums and cultural institutions. With SCALEX museums shall prepare and realise adaptive, knowledge based exhibitions and exhibition components. SCALEX uses metadata-based knowledge repositories for the authoring of the exhibition and for the programming of interactions between visitors and exhibition components. SCALEX endows the visitor of an exhibition with the ability to modify its content by selecting traversals of the entire exhibition and by browsing additional content. SCALEX recognizes user behaviour and presents customized content to specific user groups and individuals. SCALEX uses state of the art internet server technology as a base for components tailored for the specific requirements of museums and exhibitions. SCALEX is tested with model exhibitions and developed in close cooperation with museums and cultural institutions to ensure that the product suits their needs.OBJECTIVESThe general objectives of the SCALEX-Project are:- to create an affordable, scalable and flexible solution for the presentation of digital media in museums, - to customize exhibition content for different user groups and personalize the exhibition experience- to deliver a metadata-based authoring tool for digital exhibitions- to integrate the publishing of digital media in exhibitions and on the web.The SCALEX technology aims at the synchronous and customizable rendering of information on a series of different displays in exhibition or presentation premises. The rendering depends on the type of display and synchronizes stationary and mobile devices, including ambient interfaces. Since SCALEX exclusively uses internet technology and internet protocols it will also allow for the publishing of exposi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synergy of milk oligosaccharides and Bifidobacterium infantis in modulating gut epithelial cell function; impact on gut barrier function and the brain-gut axis' under Seventh Framework.

assistant: **Concept**

The role of gut microbiota in modulating the brain-gut axis and in control of food intake and obesity has recently emerged. My out-going phase host, Dr Raybould at UC Davis (USA), is an internationally renowned scientist in the field of gut chemosensing by entero-endocrine cells (EEC) and signalling to the brain through vagal afferents. Preliminary experiments in her laboratory demonstrate a synergetic effect of milk oligosaccharides (MO) and a commensal bacteria, Bifdobacterium infantis in activating EEC. Using a multi-disciplinary approach and state-of-the art techniques, I aim to investigate i) how MO potentiate adhesion of B. infantis on epithelial cells through specific surface proteins and ii)  what are the functional consequences at the intestinal epithelial cells and the brain-gut axis levels of such interactions. This will train me in methods and knowledge on EEC and vagal afferent signaling which I need to get in order to lead a small scientific group in the newly created ADNC unit at INRA, Rennes (France). This innovative project will provide basic knowledge on microbiota-EEC-vagal afferent interactions critical in the understanding of obesity and metabolic disorders, chronic diseases which are becoming a burden in our societies. It is also a unique ability for Europe to accelerate translation of a protective mechanism from human milk into wide-reaching nutritional strategies aimed at gut and metabolic health in humans. Moreover, the complementary skills (management of a multi-disciplinary project, student supervision, grant writing and creation of a multidisciplinary network within the Milk Bioactive Program at UC Davis) I will be trained in, ensured by the mentoring experience and the highly interactive environment of both host laboratories,  will reinforce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Practical design and analysis of certifiably secure protocols - theory and tools for end-to-end security' under Seventh Framework.

assistant: **Concept**

State-of-the-art technologies struggle to keep pace with possible security vulnerabilities. The lack of a consistent methodology and tools for analyzing security protocols throughout the various stages of their design hinders the detection and prevention of vulnerabilities and comprehensive protocol analysis. Moreover, state-of-the-art verification tools typically only address particular narrow aspects of a protocol's security and require expert knowledge; hence they do not help protocol designers. The challenge is to guarantee end-to-end security - from high-level specifications of the desired security requirements, to a specification of a security protocol that relies on innovative cryptographic primitives, to a secure, executable program. This proposal addresses key steps of this challenge: our goal is to develop a general methodology for automatically devising security protocols and programs based on high-level specifications of selected security requirements and protocol tasks. This includes developing a user-friendly interface for specifying the protocol's intended behavior and high-level security requirements, devising suitable abstract protocols, selecting suitable cryptographic instantiations, and generating a secure, streamlined implementation. This methodology will also include novel verification techniques that complement all design phases along with a theory which propagates verification results from phase to phase with the ultimate goal of certified end-to-end security. This includes developing type systems for analyzing abstract protocols, a general framework for conducting cryptographic proofs, and techniques for reasoning about executable code. The tools we develop should be automated and usable by non-experts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Fascinating World of Researchers in the Age of Technology' (FAWORIT), addressing dissemination and exploitation.

assistant: **Impact**

Scientists are often not regarded as “ordinary” people, but as queer creatures, who have nothing in common with average humans. The main objective of our proposal is to overcome and change these stereotypes and contribute to the reinforcement of public recognition of researcher. We would like to present the life of researchers from several aspects in order to get it closer to everyday people. The Fascinating World of Researchers in the Age of Technology will reveal in front of our eyes on 24 September, 2010. The series of events – at 6 locations – will focus on the Researcher – on his professional and on his “private” life. The public will be “edutained” during the Night: scientific talks, presentations will be mixed with entertaining elements. There is going to be a laser show, a theatre piece on the life of a young researcher, a poster competition, several concerts by researchers, cooking, fashion show, live TV broadcast, etc. The target audience can thus discover that the life of the researcher is interesting, cool, enjoyable and profitable. We will also show that researchers have a leading role in a competitive, knowledge-based society.Another aim of the project is to motivate the youth to choose scientific profession and thus increasing the number of researchers in the EU. Therefore, the target group of the Night will include younger generations (from the age of 7 to 25), but naturally, everybody can find an attractive programme for him/herself. Our goal is to attract around 10,000 people to the Night itself, but a multiple of that number (around 150,000) will see, hear or read about this unique event. We would also aim at raising awareness of the European engagement in R&D. In the European corner and at each venue, related programmes of the European Union will be