RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing mechanisms for assessing the risk of crime due to legislation and products in order to proof them against crime at an EU level' (MARC).

assistant: **Concept**

Despite the demand for legislative and product crime proofing, there has been little research and implementation. Project MARC wants to satisfy this demand, which comes from EU institutions, national governments and the market (consumers and producers). Its aim is to produce knowledge of the problem and mechanisms to help policymakers and businesspeople, at national and EU levels, to assess and reduce the risks of (organised) crime. Its objectives are:1 ) to create a crime risk assessment mechanism (cram) to proof EU legislation against economic and organised crimes, thereby reducing the probability that such crimes occur due to opportunities arising from legislation;2) to create a cram to proof electronic products against theft, thereby reducing the probability that a theft occurs due to the attractiveness of products. For both objectives a detailedplan of action will be put in place.To achieve obj. 1, the project will review extant literature on legislative opportunities for crime; analyse EU economic and organised crime case studies (vulnerabilities studies); and carry out a pilot study on EU public procurement legislation (with detection of loopholes and proposals for remedial action). To achieve obj. 2, the cram will be tested on a sample of electronic products and a final mechanism will be drafted together with possible steps to make it operational in the electronics industry. A workshop with EU legislators and a conference on product crime proofing will be among the dissemination strategies.Establishing crime proofing mechanisms would mean providing instruments to anticipate and prevent crime, reducing its total amount and achieving more security and opportunities for EU citizens, as required by the objectives of the 6FP (Area 8.1.B.2.6). The partners and the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'THE DEVELOPMENT OF A NOVEL INTEGRATED SUPER HIGH FREQUENCY (SHF) NON CONTACT DETECTOR UNIT FOR MOBILITY DETECTION AND SPEED MEASURMENT' (SHF) under Sixth Framework.

assistant: **Objectives**

False burglar alarms waste 3.3 billion p.a. and normally activated by motion detection. These are the direct costs to police and 3,200 SME crime prevention companies, with additional costs and distress to property owners (domestic and commercial), the 5 million European SME retailers are one of the most vulnerable groups to these false alarms. There is therefore an urgent need to improve the performance of these alarms to reduce this failure level. With price a main buying driver, performance improvement at the same cost is critical. This will directly increase crime prevention efficiency, impacting on over 2 million p.a. burglaries in Europe. To improve performance quality, it is necessary for improved, more reliable and cost effective sensors. Using 24 GHz instead of traditional 10 GHz frequency for sensors will increase performance reliability and be less sensitive to installation location error, through its more appropriate attenuation and propagation characteristics. However current 24 GHz sensors are too large and costly for this use.The EU wants to harmonise frequencies for short range sensor and security systems to 24 GHz band, releasing lower frequencies for longer range applications. Therefore, there is a need to develop a high performance low cost microwave motion detector operating at 24 GHz.There is a current and growing European market for 60 million multi-sensor alarms. This involves over 7,500 SMEs producing and distributing. There are also a further 27,500 SMEs involved in the installation and maintenance of crime prevention systems this will help them increase their sales. The proposed RTD is in response to the urgent industrial need to develop a solution for a universal microwave detector unit meeting the need of frequency harmonisation while helping
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional optical probes for otology' (FOIPO), addressing dissemination and exploitation.

assistant: **Impact**

Various pathologies directly impede the conduction of sound through the human middle ear, and thereby produce a ‘conductive’ hearing loss which is the second most prevalent health issue globally. According to Hearing Health Foundation more than 360 million people suffer from hearing disorders worldwide. Hearing depends on a series of events that change sound waves in the air into electrical signals. Sounds that travel down the ear canal set the surface of the flexible eardrum or tympanic membrane (TM) into rapid pico- to nanometer scale vibrations.  These motions are coupled to the inner ear by the ossicular chain (the malleus, incus, and stapes). Since the TM and ossicular chain are the primary portal through which acoustic stimuli reach the inner ear, pathological changes in the TM or ossicular chain result in conductive hearing losses.  Accurate diagnosis of middle-ear diseases is critical to effective and timely treatments of hearing loss. No currently available clinical technique is capable of simultaneously visualizing and quantifying the structure and sound-induced vibration of the middle ear in vivo. Recently, a new functional imaging technique based on optical coherence tomography (OCT) and the principle of vibrography for middle ear imaging was demonstrated. In this method, termed OCT-vibrography, a speaker is used to excite acoustic vibration in the tissue, and the resulting tissue displacement is captured by OCT. The goal of this project is to make for the first time a miniaturized OCT-vibrography probe for middle ear imaging at high frequencies. The miniaturized probe will be designed through integrated optics which will enable high-speed imaging. The system will operate in two modes: static imaging mode for examining biofilms and ear infections behind the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'An integrated approach to protein stability in thermophilic organisms' in the context of a Fifth Framework call.

assistant: **Objectives**

The proposal aims at identifying the intrinsic structural factors that confer thermopile proteins higher thermo stability. A comparative study of wild type and mutant plastocyanin will be performed using a variety of chemical-chemical and spectroscopic techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy saving and reducing carbon dioxide emission by applying advanced ammonia/water absorption chillers and decentralised Trigeneration (CCHP) technology to small and medium enterprises' (CCHP) under Horizon 2020.

assistant: **Objectives**

The UN have recently succeeded in Paris on the urgent and highly prioritised need to meet new climate goals within the coming decades, which will result in the request for a broad engagement in new approaches and technologies for sustainable energy production and more efficient use of energy, well reflected in the work programme of EU and esp. Horizon 2020. In this context, TRISORP proposes an innovative approach to cold production that fully fits with these objectives and promises a significant contribution to energy efficiency and reduction of greenhouse gas emissions. It has high potential to significantly reduce primary energy consumption and process costs for clients whereby generating significant business and employment growth with focus on Europe.The innovative approach of TRISORP is based on a revolutionary new, but field proven technology for heat-driven absorption chillers in the small capacity range, which allows for cost efficient system design for medium size applications, for which no alternative to the state-of-the-art, inefficient and environmentally harmful compression chillers is available up to now. The consequent application of the “intelligent simplicity” principle has reduced investment burdens and increased the overall profitability for clients so dramatically that, for the first time, absorption refrigeration becomes applicable in mass markets. The technology allows for saving up to 73% of primary energy consumption and thus up to 73% of greenhouse gas emissions of cold production. The initial addressable market segment is relevant and the unique selling proposition of KKS promises a high market share and profitable business. Additionally, the market is expected to grow significantly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MACROPHAGES ON THE ROAD TO B?' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Transcription factors have been shown to play an important role in the tight control and for fine-tuning of lineage decisions that take place during the development of the various different cell types present in blood. Interestingly, certain factors appear to be essential for genetic programming of specific lineages, and in the absence of such factors, lineage promiscuity has been observed. We have now derived a novel mouse model system to further address the role of specific myeloid transcription factors during hematopoeisis and to determine their essential functions during macrophage specification. Interestingly, in vitro differentiation of cells derived from these animals gives rise to terminally differentiated, functional macrophage cultures with sustained self-renewing activity. Preliminary results show that in addition to myeloid-specific markers, such macrophages can upregulate some B-cell specific genes in response to M-CSF withdrawal. Whereas lymphoid to myeloid reprogramming has been well documented, the reverse has not been achieved. Here we will analyse whether macrophage to B-cell reprogramming is also possible and outline a novel experimental system to test this hypothesis both in vitro and in vivo. Knowledge gained from these experiments will add strength to a growing body of evidence supporting the role of specific transcription factors in the control of lineage reprogramming and plasticity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intelligent Automated Methods for Monitoring Agriculture with Remote Sensing' (IAM4MARS).

assistant: **Concept**

Remote sensing images have been a significant information source for many different applications, especially for monitoring agricultural and environmental resources. Yet knowledge extraction from them is often performed by domain experts using heavily interactive computer-aided photo-interpretations due to lack of powerful automated methods. Improved spatial/spectral resolution in recent years provides details for precise monitoring, in expense of making the problem even more complicated. For monitoring agriculture in Europe, we will innovatively propose an unsupervised automated method (with limited interaction) based on advanced similarity criteria utilizing spectral/spatial characteristics and on manifold learning techniques for clustering large data sets of very-high resolution images. This will provide a fast and accurate approach for assessment of agricultural systems at the community level, which is currently done by expert image analysis. In addition, the research addressed here (novel similarity criteria harnessing different types of information and hybrid clustering), which will certainly contribute to the EU’s research excellence in remote-sensing and data mining, are expected to be advantageous for other remote-sensing applications, and also for clustering other large data sets. This will lead to interdisciplinary applications of the proposed study resulting in greater applicability beyond agricultural monitoring (which has already a broad application area encompassing whole EU, concerning about 9 million farmers and 140 million reference parcels).The CIG will integrate Dr. Taşdemir, an early career researcher with postdoctoral experience at EC Joint Research Centre (where he received the best young scientist award) and a PhD from Rice University, USA (where
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Elucidating the molecular mechanisms underlying brite adipocyte specification and activation'.

assistant: **Objectives**

Brown adipocytes can dissipate energy in a process called adaptive thermogenesis. Whilst the classical brown adipose tissue (BAT) depots disappear during early life in humans, cold exposure can promote the appearance of brown-like adipocytes within the white adipose tissue (WAT), termed brite (brown-in-white). Increased BAT activity results in increased energy expenditure and has been correlated with leanness in humans. Hence, recruitment of brite adipocytes may constitute a promising therapeutic strategy to treat obesity and its associated metabolic diseases. Despite the beneficial metabolic properties of brown and brite adipocytes, little is known about the molecular mechanisms underlying their specification and activation in vivo. This proposal focuses on understanding the complex biology of thermogenic adipocyte biology by studying the epigenetic and transcriptional aspects of WAT britening and BAT recruitment in vivo to identify pathways of therapeutic relevance and to better define the brite precursor cells. Specific aims are to 1) investigate epigenetic and transcriptional states and heterogeneity in human and mouse adipose tissue; 2) develop a novel time-resolved method to correlate preceding chromatin states and cell fate decisions during adipose tissue remodelling; 3) identify and validate key (drugable) epigenetic and transcriptional regulators involved in brite adipocyte specification. Experimentally, I will use adipose tissue samples from human donors and mouse models, to asses at the single-cell level cellular heterogeneity, transcriptional and epigenetic states, to identify subpopulations, and to define the adaptive responses to cold or β-adrenergic stimulation. Using computational methods and in vitro and in vivo validation experiments, I will define epi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The transnational repertoire:the transformation of the activism forms the example of environmental movement in Europe' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content eczema, hayfever) in childhood has increased during the last decades to about 20 - 30 %. House dust mite (HDM) sensitization has a key role in the pathogenesis of asthma and has an impact on eczema and perennial rhinitis. Complex avoidance measures during the first year of life can prevent the atopic manifestation in a significant number of children. Encasing of mattress and bedding - simple to do, but at significant costs - has proved to be efficient in treatment of HDM-allergic patients; its role in prevention still has to be defined. Objectives : The proposed concerted action facilitates the evalutation of simpl preventive measurements against the development of atopic diseases from birth to the age of nine years, both in terms of efficiency and cost-effectiveness under the different health plans of five European countries. Study design : The prospective randomised study includes newborns, children at and 6 years, each cohort to be followed for 3 years to cover the whole timespan quickly. The recruitment procedure has to identify children at risk for atopic disease (family history, sensitization already present in the child). The prevention/intervention measures will consist of health counselling, HDM allergen avoidance measures, namely encasing mattress and bedding, and simple reinforcment visits. The controls will have health counselling alone. The outcome variables are sensitization against HDM and manifestation of atopic disease. Task for concerted action : The European dimension of the study will facilitate a quick recruitment of the study population. At the same time the standardization of study instruments (questionaires, allergy tests, counselling, allergen avoidance procedures, diary cards, outcome protocols) allows a valid co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REdox Antimalarial Drug discovery' (READ-UP) targeting Sixth Framework.

assistant: **Abstract**

The READ-UP project aims at identifying antimalarial drug candidates (1 candidate and two back-ups). The project starts from a hit identified in a first series to enlarge it and design other series through the different steps of drug discovery and hit to lead optimisation until the pilot scale production for further proceeding to pre-clinical studies. The natural antimalarial product artemisinin and its derivatives are increasingly important in the treatment of drug-resistant malaria as they are the most p otent antimalarials available, rapidly killing all blood stages of the malaria parasite. Artemisinins contain an endoperoxide bridge which plays a key role in the antimalarial activity with a mode of action starting from radical transient species initiated by the cleavage of this bridge. To improve the properties of artemisinins (solubility, pharmacokinetics and costs), many research groups have proposed synthetic analogues and the goal of a cheap, synthetic endoperoxide antimalarial has not been achieved y et. One of the major difficulties is located on the oxygen-oxygen bridge which is chemically unstable, leading to short in vivo half-life which remains a limiting factor. The READ-UP project starts from the unique mode of action of artemisinins to develop a totally new approach: initiate radical transient species within the parasitized red blood cell in such way that no endoperoxide bridge is required. A strong redox activity is generated during the intra-erythrocytic development of the parasite producing f ree radicals. Our innovative approach is to take advantage of this natural primary free radical production to direct it against the parasite by designing chemical entities able to trap these radicals to give secondary transient radical species toxic for th e par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'RE-IMAGINE-CROPS – A real-time mobile multimodal positron emission tomography and multiphoton endoscopic technology for REalistic in-field quantitative IMAGING of CROPS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Sustainable agriculture strategies have become central to European and global orientations as the demand of food increases with the rising world population. Current technologies qualitatively drive the application of Nitrogen (N)-fertilizers to stressed field areas but cannot precisely modulate the needed amount, resulting in dangerous N dispersion, ecological and economic losses. RE-IMAGINE-CROPS envisions applying basic plant science into crop management by quantitative “in-field” measurements of biophysical processes occurring at tissue and cellular level. The consortium will implement the first real-time in-field portable multimodal multiscale Positron Emission Tomography (PET)-Multiphoton Endoscope (ME) technology. PET measures the metabolic processes in the crops at the scale of hundreds of micrometers, while guiding the ME system to visualize functional mechanisms at a cellular level. The aim is to tailor the amount of fertilizer to be used by enabling measurement of functional processes reflecting the local and systemic crop signal pathways triggered by N-fertilizer shortly after application.RE-IMAGINE-CROPS involves real-time PET reconstruction, hydrodynamic modelling, optical fiber transmission optics, and features identification in multiple scales. It enables a new multimodal, mobile technology for the first time, with unprecedented spatial resolution (0.6 mm;1um) and real-time functionality at a rate of (2;10) Hz. These are enabled by a multimodal PET-ME tracer based on the Lifeact-Venus protein labeled with 89Zr. RE-IMAGINE-CROPS brings together eight institutions with leading scientists and cross-disciplinary expertise. Among them, EURO-BIOIMAGING ERIC and BFEDU, a large agrifood enterprise, will boost the impact and dissemination of this novel technology