RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NEXT GENERATION PRODUCTION SYSTEMS' (NEXT).

assistant: **Concept**

The Integrated Project NEXT aims at commiting the European production machinery industry to new frontiers in diverse fields. The main objectives of the project are the following: 1.THE GREEN MACHINES: Environmentally friendly machines. The aim is to get machines that consider environmental aspects through their entire life-cycle: use of recycled materials for machine elements (#gt;50%), reduction of energy consumption (25% at least) at machine use, zero waste produced, dismantling and recycling of 100% ma chines 2.THE USER CENTRIC AUTONOMOUS MACHINE. The objective is to get machines that help the operator in all his/her tasks by a complete set of features (added applications, ergonomic aspects, improved maintenance aspects) heading users support and satis faction as well as automatically recognise machining tasks and process conditions. 3.THE MANUFACTURING FRONTIERS: Process oriented high performance production equipment. The aim is to get 5x improvement in machine productivity, as well as an order of mag nitude improvement in machine accuracy, compared to current available machines 4.NEW BUSINESS PARADIGM FOR MACHINERY: New paths to create value for the machinery business. The exploitation objectives of the project target the commercialisation of the dev elopments, by the industrial companies involved, by the generation of take-up companies and by the definition of new ways of doing business in the machinery sector (e.g. selling production hours instead of machines) 5.NEW CONTENTS FOR TRAINING AND DISSEM INATION AROUND PRODUCTION EQUIPMENT. The dissemination task will target both academic and professional training, by the generation of new contents arising from the research and establishing the means to reach the target audiences, focusing specially in mac hine using a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unraveling the mechanisms behind Mitochondrial Transfer from Bone Marrow Stromal cells to T cells and its role in Host Immunity' (MitoTransferImmunity), addressing dissemination and exploitation.

assistant: **Impact**

Mitochondria are organelles (‘little organs’) of the cell that generate the majority of its energy and have been shown to play a key role in host immunity. Recent evidence has demonstrated that mitochondria within a cell are not fixed, but are capable of transferring from one cell to another through a process known as ‘mitochondrial transfer’. My project focus on the transfer of mitochondria from bone marrow stromal cells (BMSCs) to immune T cells. The objectives of the project are to explore  the  effect of BMSC mitochondrial transfer cells on (i) immune T cell functionality (in particular ROS production)  and (ii) its role in adaptive immune cell responses. The MSCA fellowship and tailored training program will help me towards my career goal of establishing my own junior research group by increasing my academic track record, helping me gain critical supervisory/teaching experience, and expand my technical/transferrable skill sets.


**Keywords:** Mitochondria, T cells
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ContraBand: the only heart failure medical device that is placed outside the heart' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Worldwide 26 million people suffer from Congestive Heart Failure (CHF), a chronic condition that worsens with time and leads to staggering healthcare costs and a significant reduction of quality of life. ContraBand is an implantable device aiming to restore heart function in patient suffering from left ventricle failure. ContraBand’s benefits include built-in fail-safe for full reversibility of functionality, tremendous ease of use due to its proprietary stеnt-within-a-stеnt design and transcatheter delivery system, and full clinical flexibility to be compatible with pharmacotherapies and other CHF devices. In the project, we will finalise clinical development and introduce ContraBand into clinical routines in Europe. We expect to launch ContraBand in 2024, generate €15M in revenues in 2025 and €60M in 2026. Before market launch, we will create >95 jobs at the company in strategic locations in Europe.


**Keywords:** congestive heart failure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phylogeography and somatic evolution of cancer tumor cells' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

By far, most evolutionary research has focused on the changes that occur in the germline of individuals across generations, within and between species. For different reasons, much less attention has been given to the process of change within the somatic line of a multicellular individual. The formation of cancer tumors due to uncontrolled cell proliferation is one of the most prominent forms of somatic evolution. The evolution of cancer tumors in a body can be likened with the evolution of populations in more or less fragmented habitats. The tumor is usually a expanding population of clonal cells, which may differentiate to a bigger or lesser extent (population structure) and disperse to contiguous (range expansion) or more distant tissues (long distance colonization). During tumor progression, this population of cells is subject to distinct somatic evolutionary processes like mutation, drift, selection or migration, which can act at different points in time and geographical space. Very recently, the discovery of extensive intratumor heterogeneity, together with the rise of single cell genomics, has created an unique opportunity to study the phylogeography of cancer tumor cells. So far evolutionary inferences drawn from cancer genomes have been mostly qualitative. Here we propose to study a thousand single cell genomes from different regions in primary tumors and matched metastases. We will develop and apply state-of-the-art statistical and computational techniques from phylogenetics, phylogeography and population genomics to understand the tempo and mode of evolution of cell lineages within and between cancer tumors. By doing so we aim to construct a robust theoretical and methodological evolutionary framework that can contribute to a better understanding of the proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'iBUS – an integrated business model for customer driven custom product supply chains' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective for iBUS is to develop and demonstrate by 2018 an innovative internet based business model for the sustainable supply of traditional toy and furniture products that is demand driven, manufactured locally and sustainably, meeting all product safety guidelines, within the EU. The iBUS model focuses on the capture, creation and delivery of value for all stakeholders – consumers, suppliers, manufacturers, distributors and retailers.The main focus of iBUS is to drive sales for EU traditional toy and furniture manufacturers by leveraging internet based technologies, focusing on safe products, quality, design and innovation. In this new iBUS model consumers become designers, designing, customising and placing orders for their own products online in the iBUS cloud. They will be supported by embedded services in iBUS, developed in the main by SME Technology providers. These services include augmented reality design assistants, design verification tools for compliance with EU product safety guidelines, analysis of environmental footprint and prototyping with additive layer / 3D printing. Subsequently, parametric engineering design principles will take the design from concept to demand. This demand will then be synchronised and optimised across the supply chain, supported by the embedded supply chain optimisation tools, to produce sustainable demand driven production and supply plans. Manufacturers will then produce the furniture and toys in small scale series production driven by the actual customer demand. Suppliers will have visibility of, and make decisions based on, end-customer demand. Likewise customers will have visibility of their orders through all stages of production and delivery. The infrastructure will be cloud based using internet and social me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Training a new breed of interdisciplinary researchers to respond to the opportunities and challenges of ageing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ageing population is one of Europe’s and the world’s grand challenges for the 21st century. How to cope with populations that are living ever longer and understanding the processes and means of tackling and benefitting from such populations has already been studied in great detail. However, the studies have mostly been independent, in often almost unrelated areas. To look at ageing throughout the whole life-course from many different dimensions, and not just in elderly people, requires a new breed of interdisciplinary research who has been trained to work on the topic within a number of different disciplines within science and the humanities. NEWBREED will address this challenge through an interdisciplinary doctoral programme, developed and coordinated by Örebro University in Sweden, in cooperation with a network of hosting organisations. These organisation nodes will open up a large network of other organisations for secondments – academic, industries, NGOs, public sector etc. NEWBREED seeks to attract 16 ESRs from Europe and the rest of the world to undertake this interdisciplinary research training. We believe that the NEWBREED programme will provide just that new breed of researcher.Örebro University is especially qualified to run NEWBREED. The programme docks in well with one of the university’s new strategic areas, namely Food and Health and that there is an existing local doctoral programme within Successful Ageing, which has acted as a pilot. In addition, the university has been involved in many age-related EU projects. The programme is divided into four themes: Ageing and psychosocial adjustment, Ageing from a societal perspective, Ageing and the fourth industrial revolution, and The biology of ageing.We believe that the graduated doctoral students will hav
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of the gut in experimental visceral leishmaniasis and Chagas disease' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Leishmania donovani and Trypanosoma cruzi cause the neglected infectious diseases visceral leishmaniasis (VL) and Chagas disease (CD) respectively. The host normally controls the initial wave of infection but rarely, if ever, fully clears the infection. Chronic, low-level infection then often progresses to serious clinical syndromes.  Infection of a limited set of favoured tissues is a parasite strategy to evade host immunity and maintain chronicity. Recent work shows the gut is a site of chronic T. cruzi infection in CD mouse models. L. donovani persists in liver and spleen, but the gut may also be a target. In cutaneous leishmaniasis, chronic persistence occurs in the skin due to unique immune responses that evolved to tolerate constant exposure to the environment. A similar situation exists in the gut, where inflammatory responses against commensal microbe and food antigens are unwarranted and potentially dangerous. As in the skin, the hypo-responsive environment of the gut may underpin host failure to clear T. cruzi and L. donovani. Persistence in the gut may compromise microbiota containment leading to secondary syndromes (as in HIV and Toxoplasmosis) or exacerbate VL/CD pathology. Project objectives include (1) assessment of relevance of the gut as a site of L. donovani persistence (2) analysis of gut-specific responses to L. donovani (3) analysis of interactions between host, parasite and commensals and impact on gut immune homeostasis and disease (4) analysis of the gut-specific responses to T. cruzi that allow persistence.  The training programme will develop a broad range of new technical and conceptual competencies to investigate general and gut-specific immunity and host-commensal interactions as well as enhanced transferable skills. This hypothesis-driven p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Role of thrombin in cardiovascular diseases. Interactions with receptors, substrates and inhibitors'.

assistant: **Objectives**

The project seeks to understand the molecular events involved in the recognition by thrombin of various cell membrane and plasma proteins. The project is focused on thrombin functions that are highly susceptible to contribute to thrombosis and associated disorders : (i) receptor-mediated cell activation, (ii) feed-back amplification of thrombin production by activation of factor V and factor VIII, (iii) thrombin inactivation by its physiological inhibitor, antithrombin.The final enzyme of the coagulation cascade, thrombin, plays a key role in the development of arterial thrombosis, associated inflammation and atherosclerosis. Thrombin is a multifunctional enzyme which induces both the conversion of fibrinogen to fibrin and cell activation, and also regulates its own production, by interacting with a number of cell membrane and plasma proteins. The X-ray crystallographic structure of the human enzyme in complex with various specific inhibitors has been elucidated, revealing that thrombin's structure can be divided in several functional regions that recognize different chemical moieties of other molecules. The remarkable specificity of thrombin for its various natural substrates, ligands and inhibitors may be ascribed to multiple interactions with the different functional regions (active site and exosites) of the enzyme, but the detailed mechanisms of these interactions remain to be resolved.The aim of the collaborative study is to identify the particular residues of thrombin that are important for its interaction with the receptor, factor V, factor VIII and antithrombin. Five teams of researchers will contribute with their extensive previous experience in the field of thrombin research and will combine their efforts by providing a wide variety of unique methodology, from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrating Forging and Process Simulation for turbine disks'.

assistant: **Objectives**

The objective of this project is the implementation of an integrated simulation chain including pre material characteristics, thermo-mechanical processing (forging and heat treatment) and assessment of microstructure and functional properties for aerospace turbine components.The integration of different computational results within an interdisciplinary and intercompany design-chain is a challenging task. A fully integrated simulation chain along the supply chain will give unique benefit for product development with respect to time, cost, and quality. This allows an optimization of the forgings in respect of weight, efficiency and CO2 reduction.Böhler Schmiedetechnik GmbH & Co KG (BSTG) has developed a model for determining the microstructure (e.g. local grain size distribution in a component) from forging and heat treatment simulations. This model is in daily use for thermo-mechanical process design and optimization of turbine disks. In past, recent and future R&D projects, Böhler Schmiedetechnik has developed models for determining the local functional properties depending on the microstructure. In a further step, aiming to the topic of this proposal, the simulation chain is to be integrated into an industrialized useful format, target-aimed to customer needs. Suitable strategies and methods for integration of the pre-material characteristics have to be assessed. The quality of the existing models has to be evaluated together with the customer. Comprehensive statistic investigations work is necessary in order to make the usage of the simulated data possible at the customer. Detailed investigations have to be executed to improve and/or generate functional properties models like yield stress, low cycle fatigue and creep models. Interfaces have to be defined and generated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation and mechanism of replication of damaged DNA: role of yeast and human Rad5 and ubiquitylation' in the context of a Sixth Framework call.

assistant: **Objectives**

The stalling of DNA replication machinery that occurs as a consequence of encountering unrepaired DNA damage is a challenging problem for cells. In humans, increased error-prone bypass of DNA lesions causes increased mutagenesis, and as a consequence, a rise in the incidence of cancers, whereas error-free replication of damaged DNA contributes to genetic stability. In yeasts, the Rad6-Rad18 ubiquitin-conjugating complex governs three alternative pathways of replication of damaged DNA: the Rad5-dependent err or-free, the DNA polymerase eta dependent error-free, and the polymerase zeta dependent error-prone damage bypass. My research work has contributed to the great progress, which has been made in the past four years toward the understanding the function of translesion synthesis polymerases and unravelling how mutations in polymerase eta cause Xeroderma pigmentosum, a cancer prone syndrome.However, it is still not known how the Rad5-dependent pathway stimulates error free replication of damaged DN A in yeasts, and whether a similar pathway in humans operates. How protein ubiquitylation governs damage bypass remains to be identified, as well. The goal of my proposed project is to answer these important questions. First, I propose to identify new protein elements in the yeast Rad5-pathway and to reconstitute it in vitro by highly purified protein factors. Second, I plan to examine human HLTF, a recently identified tumour suppressor, which can be the human homologue of yeast Rad5. I further propos e to unravel the role of protein ubiquitylation in giving access to Rad5 and translesion synthesis polymerases to the stalled replication machinery. My study will extend our understanding of the molecular events of DNA damage tolerance pathways, which prevents mutagenesis and car
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ScraPping cArbon Reinforced ThermoplAstic.' (SPARTA) under Horizon 2020.

assistant: **Objectives**

In the aerospace industry the reinforced composite materials are more and more demanded, where the end-of life (EoL) of the final product aspect is very debated point nowadays. The thermoplastic materials play a key role because of their recycle properties. This fact can bring about a challenge to design recycling techniques to extend the EoL of the reinforced composite parts. However, any of this current recycling methods can recover by 80% of the thermoplastic (TP)fibre and ensure the acceptable mechanical properties of the rCF(recycled carbon fibre).The project will provide a solution by developing a recycling method for the key process steps: scrapping by cutting mechanic, automatic deposition and compression moulding manufacturing. The selection of the most suitable recycling process will be based on the previous studies performed by the partners and a comparison with the state of the art of the TP recycling techniques. Then, the scrap material obtained in UD tape format(50x6.0.15mm3)will be deposited automatically with a robot collaborative resulting a preform panel which will be manufactured by compression moulding means. The automation advantage will allow to reduce the labour cost and the manual defects. The estimated cost per kilo of the scraped material will be 0.37€/kg, a very competitive cost for a real alternative to a high cost material(> 30€/kg).The consortium consists of all key players that will play a future role in the recycling and manufacturing of TP rCF composites. AIMPLAS will play a leading role in the consortium as far as the recycling methods in thermoplastic composites is concerned. This knowledge will be complemented by TEKNIKER with a vast experience in experience in the design and manufacturing of special cutting tools.The project will con