RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated system to manage the enormous complexity of the genome and proteome of the specific immune response: imgt, the international immunogenetics database.' (IMGT) targeting Fifth Framework.

assistant: **Abstract**

Europe has taken a lead in the development of IGMT, an high-quality integrated ImMunoGeneTics database, unique in the world, specialised in the complex gene families of the specific immune response in human and other vertebrates: Immunoglobulins (Ig), T cell Receptors (TcR) and MHC. LIGM-CNRS (F), EBI (UK),ICRF (UK), BPRC (NL) and EUROGENTEC (B) propose to expand IMGT into an information system which will integrate and provide a common access to all protein, polymorphism and structural Ig, TcR and MHC data. By management of the enormous complexity of the immunogenetics data, IMGT will be crucial for functional and comparative genomics of the immune system, biotechnologies, and therapeutic approaches such as vaccines, grafts, and immunotherapies. IMGT will be of immense value for Medicine, Biotechnology and the European Pharmaceutical Industry, and will considerably help to strengthen Europe's role in these areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of substance p in the developing central nervous system' to be submitted under Fourth Framework.

assistant: **Abstract**

The degree to which neuronal phenotype in the developing spinal cord is progressively restricted by environmental signals is poorly understood. I intend to investigate this problem by examining targeted deletions of the NK1 gene in mice. This gene has been implicated in a particular aspect of the neuronal development such as the dorsoventral patterning of the neural tube and axon guidance across the midline. Embryos will be analysed using immunochemical, in situ hybridisation and dye tracing techniques, and in vivo approaches will be complemented by in vitro analysis after pharmaco logycal manipulation using spinal cord explants in collagen gels and roller culture of postimplantation embryos.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A novel immunity-based test for early diagnosis of Lyme disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of this ID-Lyme project was to push to the market a novel test, the Ixodes kit, for the early detection of Lyme Borreliosis (LB), also known as Lyme disease. LB can usually be treated using cost-effective antibiotics at an early stage of disease. Unfortunately, standard laboratory testing is often unable to give a clear diagnosis whether a patient is infected or not. This can result in the true infection remaining untreated. This is a significant healthcare concern because of the disabling effects and the much costlier and more challenging treatment of progressive disease. This project was to deliver to the market the first point-of-care diagnostic test that can identify LB infections in the early stage prior to the onset of symptoms thereby improving LB management and patient health outcomes as well as reducing LB-related healthcare costs. When successful, the project would have significant impact on EU healthcare and society, as currently over 2.6 million tests are performed in the EU each year on people suspected of LB infection.With support of the Fast Track to Innovation program by Horizon2020, a dedicated consortium of in vitro diagnostic assay developers (Innatoss Laboratories), production specialists (NPK, Diarect) and clinical experts (Medical University of Vienna) will finalize the kit design, upscale production, and test the product under real-life conditions to prepare the kit for EU-wide market introduction and implementation. The Ixodes kit will result in: 1. early and effective treatment of patients;2. quality of life of patients; and 3. large direct and indirect cost reductions on a EU-wide level. Unfortunately, the discriminatory power of the Ixodes test was insufficient to progress to the intended performance study. Instead, the WOLF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Artificial Intelligence in Colonoscopy for Cancer Prevention' (ACCEPT).

assistant: **Innovation**

Removal precancerous polyps (so-called adenomas) during colonoscopy reduces colorectal cancer incidence and mortality. We have recently developed artificial intelligence (AI) systems which optimise colonoscopy quality by aiming at increasing the detection of adenomas. However, it is unknown if this benefit of AI translates into improved cancer prevention. To establish the role of AI in colorectal cancer prevention, we here propose a three-step research portfolio targeting individuals in the national colorectal cancer screening programmes in Norway and Poland. 1) A 1-year observational study to clarify the superiority of AI in adenoma detection in the average-risk population. 2) A cost-effectiveness analysis for cancer prevention, using real-world data obtained from the part 1 study. 3) Establishment of an infrastructure for long-term (10 years) follow-up of 40,000 individuals to quantify the effect of AI on colorectal cancer incidence. We use propensity score matching to balance the background characteristics of the two comparing arms; AI-assisted colonoscopy and standard colonoscopy. Participants are followed through national cancer registries for ten years after cancer screening. Our project is the first of its kind and made possible by the unique collaboration of world-class environments in clinical epidemiology and medical device assessment with world-leading AI developers. The project will enable evidence-based implementation of AI technologies into nationwide cancer screening programmes in Europe and the world. The project’s achievement will be maximised through detailed plans for training, monitoring, management, exploitation, dissemination, and communication. While adding essential competence to the host institution, this project will increase the applicant’s sk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Manifesting the Simplicity of Scattering Amplitudes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

I propose a program of research that may forever change the way that we understand and use quantum field theory to make predictions for experiment. This will be achieved through the advancement of new, constructive frameworks to determine and represent scattering amplitudes in perturbation theory in terms that depend only on observable quantities, make manifest (all) the symmetries of the theory, and which can be efficiently evaluated while minimally spoiling the underlying simplicity of predictions. My research has already led to the discovery and development of several approaches of this kind. This proposal describes the specific steps required to extend these ideas to more general theories and to higher orders of perturbation theory. Specifically, the plan of research I propose consists of three concrete goals: to fully characterize the discontinuities of loop amplitudes (`on-shell functions') for a broad class of theories; to develop powerful new representations of loop amplitude {\it integrands}, making manifest as much simplicity as possible; and to develop new techniques for loop amplitude {integration} that are compatible with and preserve the symmetries of observable quantities.Progress toward any one of these objectives would have important theoretical implications and valuable practical applications. In combination, this proposal has the potential to significantly advance the state of the art for both our theoretical understanding and our computational reach for making predictions for experiment.To achieve these goals, I will pursue a data-driven, `phenomenological' approach—involving the construction of new computational tools, developed in pursuit of concrete computational targets. For this work, my suitability and expertise is amply demonstrated by my rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intelligent DC/DC converter for fuel cell road vehicles' (INTELLICON).

assistant: **Innovation**

Current hybrid electric vehicle power trains comprise on-board energy generation, energy storage and traction drive, where the battery is used for energy storage is heavy or expensive or both and requires regular maintenance. Best practice is to use super-capacitors with batteries, reducing the deep charge-discharge cycle and battery size (hence weight and cost).The Intellicon power train replaces batteries with a novel DC/DC converter (the Project deliverable) as an interface between the fuel cell and traction system and super-capacitors. Super-capacitors are light weight high power energy storage devices which have a operational life typical equal to that of the vehicle. The DC/DC converter will monitor fuel cell operational safety and reliability through intelligent control that will allow super-capacitor voltage to vary within acceptable limits as the traction system accelerates and decelerates, whilst maintaining a steady optimized power flow from the fuel cell without risk.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Glycodrugs: new strategies for controlling the activity of glycosidase enzymes and their application in therapies for lysosomal storage diseases and cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

This project aims to new strategies for the preparation of glycomimetics specifically designed to regulate the activity of enzymes involved in pathological processes (glycodrugs). We will focus on the design of glycomimetics to modulate the activity of glycosidases. Particular emphasis will be placed at developing diversity-oriented synthetic strategies to optimize specificity.The target applications are two: elaboration of chemical chaperones for the treatment of lysosomal storage disorders (LSDs; Gaucher disease, Fabry disease and gangliosidosis GM1), and the development of compounds with antiproliferative activity in breast cancer.Compounds able to establish specific interactions with regions of lysosomal glycosidases (beta-glucocerebrosidase and alpha- and beta-galactosidases) surrounding the active site will be designed by incorporating substituents with well-defined orientation. In addition, pH-sensitive elements that will allow an effective bond to the enzyme in the endoplasmic reticulum (ER) will be inserted, forcing the correct folding and providing the traffic to the Golgi apparatus, and at the same time the dissociation of the enzyme:chaperone complex in the lysosome, and thus favouring the rescue of the mutant proteins that cause the disease and the processing of the substrate. Molecular vehicles will also be developed for the directed transport of these chaperones to cells particularly affected in patients with LSDs. For biodistribution studies, labelled derivatives with fluorescent probes will be prepared.The ability to control the specificity of action by incorporating pseudoaglyconic substituents in bicyclic skeletons sp2-iminosugar-type, also allows the design of specific inhibitors for alpha-glucosidases (ER) or for alpha-mannosidases (Golgi). These en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ERGONOMIC INSTRUMENTS DEVELOPMENT FOR HIP SURGERY. AN INNOVATIVE APPROACH ON ORTHOPAEDIC IMPLANTS DESIGN' (ENHIP).

assistant: **Concept**

Nowadays market on hip prosthesis is going from traditional procedures where instrumentation and product design provoke an important time and effort requirements in operating theatre to a new scenario where minimally invasive surgery (MIS) will substitute progressively old techniques. In both cases the role of instruments design is very important, but even relatively more important in minimally invasive techniques, because it will be impossible to fit the prosthesis without an appropriate instruments design. Although prosthesis and instrumentation are part of the final system and instruments have a high influence in the implant selected, low efforts have been dedicated in the past to the design of the instruments. This makes the development of innovative ergonomic instruments for hip surgery a very innovative approach to the problem. The aim of the project is the development of instrumentation to use in both open orthopaedic hip surgery and minimally invasive surgery (MIS) under ergonomic design criteria to improve the working conditions of the surgeons during the operation, keeping the same clinical and mechanical functionality of the instrumentation, according to the current standards requirements. The main objectives of the project are:Develop a new instrumentation designed for the surgeon that will provide implant manufacturers involved on the project an important advantage to sell their products in the market.Improve the surgeon working conditions developing a new generation of instruments to use in hip surgery through the ergonomic design criteria to improve the current designs, which are based only in functionality and durability.Reduce the operation length thanks to an easier use of the instrumentation due to its ergonomic design.Development of instruments for m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NMR in Inorganic Structural Biology' (2002-2006) under Sixth Framework.

assistant: **Objectives**

This host institution is a Research Infrastructure supported by the European Commission for providing transnational access to biological NMR. The infrastructure is uniquely equipped with a large number of NMR spectrometers ranging from 900MHz down to 0.01MHz, through 800MHz, two 700MHz, 600MHz, 500MHz and 400MHz spectrometers. It has a specialised tradition in the investigation of metalloproteins and in particular of paramagnetic metalloproteins.The aim of this application is that of moving ahead the perspective of Biological Inorganic Chemistry through the training of a new generation of doctorate students, trained at the interface between biology and inorganic chemistry through biocomputing and biospectroscopy. The availability of high technology NMR methods to study at the atomic level the structure and mobility of metalloproteins and their adducts with physiological partners and small synthetic ligands is of crucial importance in the post-genomic era. The use of the genomic databases will be exploited through bioinformatic tools for the selection of proteins for expression and for characterisation in terms of structure, stability, recognition of biological partners, specificity and discovery of new folds and functions.Chemistry oriented fellows will develop aspects related to the role of metal ions in biological systems; biologically oriented fellows will go through an integrated approach from genome to proteins by using high throughput techniques, bioinformatic tools and will be exposed to spectroscopic techniques; biophysics oriented fellows will develop technological and scientific aspects through the use of high and low field NMR and flanking biophysical spectroscopy. The long-term educational aim is to create scientists capable to frame specific problems in a g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Lightweight and rEliable Emergency exits and cabin footstep for fast Rotorcraft' (2014-2020) under Horizon 2020.

assistant: **Objectives**

To save more lives, civilian rotorcraft operators need to reduce operating time in the Search and Rescue missions or Emergency Medical Services. The primary answer to this time saving challenge is firstly, increase the speed of the rotorcraft and secondly, develop some innovative rotorcraft sub-systems facilitating patients access to the rescuers and the rotorcraft. Coupled to speeder, safer, more environmentally friendly, and more cost-efficient demands for the next generation of rotorcraft, CLEVER project is a perfect response to this challenge. Participating to the LifeRCraft Fast Rotorcraft development lead by Airbus Helicopter, Vision Systems Aeronautics through the CLEVER project will focus on the two main sub-systems development in the rotorcraft access in period of urgency: the emergency exits and the cabin footstep. In addition, acoustical and optical performances enhancements are proactively proposed to reinforce pilot’s safety and passenger’s comfort. Being a recognized EASA Part 21G Tier One System Supplier, Vision Systems Aeronautics proposes to completely develop and produce enhanced lightweight and aerodynamically efficient innovative composite doors and cabin footstep for the Clean Sky 2 FRC program able to be shortly introduced in mass-production. From first concept study at TRL4, up-to final qualification and flight test campaign completion and support at TRL8, Vision Systems Aeronautics will be the Partner expected by the Topic Leader, proposing simultaneously innovations and safe production readiness. A total of three complete high performant doors (left cockpit, right cockpit and cabin) and one cabin footstep demonstrators will be produced to issue required qualification tests, to deliver first functional airworthy prototypes and to equip the flying
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'RHEOLOGY OF EARTH MATERIALS: CLOSING THE GAP BETWEEN TIMESCALES IN THE LABORATORY AND IN THE MANTLE' (TimeMan), addressing dissemination and exploitation.

assistant: **Impact**

Most large-scale geological process such as plate tectonics or mantle convection involve plastic deformation of rocks. With most recent developments, constraining their rheological properties at natural strain-rates is something we can really achieve in the decade to come.  Presently, these theological properties are described with empirical equations which are fitted on macroscopic, average properties, obtained in laboratory experiments performed at human timescales. Their extrapolation to Earth’s conditions over several orders of magnitude is highly questionable as demonstrated by recent comparison with surface geophysical observables.Strain rates couple space and time. We cannot expand time, but we can now reduce length scales. By using the new generation of nanomechanical testing machines in transmission electron microscopes, we can have access to elementary deformation mechanisms and, more importantly, we can measure the key physical parameters which control their dynamics. At this scale, we can have access to very slow mechanisms which were previously out of reach. This approach can be complemented by numerical modelling. By using the recent developments in modelling the so-called “rare events”, we will be able to model mechanisms in the same timescales as nanomechanical testing.  By combining, nanomechanical testing and advanced numerical modelling of elementary processes I propose to elaborate a new generation of rheological laws, based on the physics of deformation, which will explicitly involve time (i.e. strain rate) and will require no extrapolation to be applied to natural processes.Applied to olivine, the main constituent of the upper mantle, this will provide the first robust, physics-based rheological laws for the lithospheric and asthenospheric mantle t