RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Single Molecule Imaging-based design of HIV-1 vaccines' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The HIV-1 vaccine research has re-emerged in the last few years due to the identification of antibodies that neutralize most HIV-1 circulating strains. A deeper understanding of the mechanistic mode of target recognition for these antibodies represents a big hope in the field. This project aims at understanding and characterizing polyclonal antibody responses to aid rational vaccine design via radically new technologies on light microscopy. The molecular mechanism of time-resolved HIV-1 fusion will be visualized and quantified on the surface of living cells by combining real-time single virus tracking, fluorescence fluctuation spectroscopy and 3D single molecule localization microscopy (SMLM) imaging. The implementation of a new technology that allows three-dimensional nanometre localization of single particles will allow us to multiplex single molecule experiments with functional readouts for single-virus HIV-1 fusion simultaneously. Here, I will systematically establish the mechanism of action of different families of neutralizing antibodies and how they disrupt the three-step HIV fusion reaction, conserved among different HIV tropism, recently discovered by our group. I will unveil the molecular insights on the precise Env-induced, time-resolved stoichiometry of CD4 and co-receptors (CCR5 or CXCR4) in the presence and absence of different combinations of bNAbs and study their impact on HIV transmission. FUSION will open new avenues to design putative drugs that target host-specific receptor and co-receptor oligomeric states to block HIV-1 fusion. This project systematically applies cutting-edge time-resolved imaging approaches as a gold standard to ascertain how different combinations of bNAbs perturb the HIV fusion mechanism in CD4+ T cells and macrophages. I will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel, highly effective and selective anticancer metallodrugs' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Dr. Leila Tabrizi, an Iranian national, is making an application to this programme to carry out a 24 months project in the area of medicinal chemistry in the group of Dr. A. Erxleben at the National University of Ireland, Galway.The objective of this proposal is the synthesis of novel gold anticancer drugs that simultaneously target two mitochondrial proteins that are associated with cancer progression. Gold(III) complexes will be designed that recognize the translocator protein which is overexpressed in various tumour types and that release the metal upon intracellular reduction to gold(I), a known inhibitor of thioredoxin reductase. Binding of the carrier ligand to the translocator protein and inhibition of thioredoxin reductase will induce cell death pathways in a synergistic manner, thus leading to highly effective and selective anticancer action. Detailed in vitro biological studies will be performed to evaluate the potential of the new anticancer drug candidates, to establish structure-activity relationships and to fully understand their mode of action.   The researcher has already an excellent background in coordination chemistry and this project will allow her to deepen and expand her skills in synthetic chemistry, to enter into the biological field by receiving relevant training in cell and biological techniques and to establish important academic and industrial collaborations.The researcher who has recently been awarded a Government of Ireland Postdoctoral Fellowship proposes to carry out further research training at NUI Galway which is strategically developing strength in Biomedical Research and Cancer, one of the most important and challenging branches of Chemistry/Biochemistry in Europe. NUI Galway will also provide training in transferable skills and mento
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fostering high scientific quality in protein research in Eastern Slovakia' to be submitted under Horizon 2020.

assistant: **Abstract**

The project “Fostering high scientific quality in protein science in Eastern Slovakia (CasProt)“ supports the second-best classical university in Slovakia, University of Pavol Jozef Safarik in Kosice (UPJS), located in one of the lowest GDP-producing regions in the Widening country Slovakia. The vital connections to the high R&I performing countries - Germany and Switzerland and the scientific excellence of our partners, Technical University in Munich (TUM) and University of Zurich (UZH), will trigger the critical steps toward becoming the UPJS as a leader in the field of protein science in Slovakia. This project will also energize a high-tech development and unfold the innovation potential of our University with the expected impact on the Eastern Slovakia region and consequently whole Slovakia. By means of short-term staff exchange, expert visits training, joint summer schools, workshops, and conference attendance, we will reach the following main objectives of the project: (1) Reinforcement scientific capacity and raise the research profile of the coordinating institution-UPJS in the field of protein science, (2) Identification and integration of the experienced and young/early-stage researchers into UPJS, (3) Enhance and stimulate the technological capacity of the coordinating institution-UPJS, and (4) Strengthening the research management and organizational skills at UPJS. The specific scientific goals of the CasProt project are: (i) to establish highly advanced protein evolution techniques of G-protein coupled receptors (GPCR), and (ii) to develop complex single-molecule force assays and instrumentations (e.g., optical tweezers with confocal fluorescence microscopy detection) for monitoring of the dynamics of wild-type and evolved GPCRs To successfully accomplish a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Transition metal-catalysed c-c bond formations metalied by chlorosilanes'.

assistant: **Innovation**

Catalysts increase the rate of chemical reactions without being consumed. Thus, small amounts of catalytically active species allow the preparation of large amounts of products. As far as carbon-carbon bond forming reactions are concerned, most of the established catalytic processes rely upon the use of nobel metals such as palladium, rhodium, ruthenium etc. Other transition metals which do not spontaneously regenerate a low-valent oxidation state after the desired C-C-bond formation cannot be used in a catalytic manner so far. This project tries to explore ways which allow to overcome this severe limitation. Chlorosilanes as cheap, readily available and non-toxic additives may pave the way. Specifically, studies on the titanium-mediated reductive coupling of carbonyl compounds to alkenes (McMurry synthesis) are proposed. A recently deviced procedure will be refined which has proved for the first time that this notoriously stoichiometric but highly useful transformation can in fact be rendered catalytic in titanium. Part of this project deals with the synthesis and evaluation of tailor-made ligands and with a detailed study of the actual nature of the intermediates involved in this catalytic process by spectro- scopic means. The insight gained during the course of this investigation will be applied to other transition metal induced reactions, which may also become catalytic when performed in the presence of an appropriate chlorosilane. The efforts will focus on those processes which hitherto require expensive and/or toxic metals in (over)stoichiometric amounts and which would become much more attractive for applications in natural product chemistry or for the synthesis of pharmacologically relevant targets if a catalytic alternative would exist.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modulation of Liver Metabolism/Inflammation at Different Disease Stages by Leveraging ADAR-based RNA Editing' (HepaModulatoR), addressing dissemination and exploitation.

assistant: **Impact**

RNA base editing, catalyzed by ADAR enzymes, is a natural process that diversifies protein function by modifying mRNA. Redirecting ADAR activity with RNA-based drugs holds significant promise for correcting genetic mutations and uniquely enables precise modulation of protein function. However, major challenges remain to fully unlock this potential.In this collaborative effort, we present a target discovery platform and demonstrate in vivo proof-of-concept (PoC) that targeted RNA base editing can mitigate chronic liver disease. Our team combines its groundbreaking insights and tools to predict functional editing computationally (PI Levanon), efficiently screen for effective edits (PI Stafforst), and establish functional PoC in animal models of liver disease (PI Heikenwälder).Chronic liver disease stems from disturbances in the liver microenvironment caused by chronic viral infections, alcohol intake, sedentary life-style/high-calorie diets or autoimmunity, all disrupt hepatocyte metabolism and regulatory signalling. This ultimately leads to liver inflammation, fibrosis, and liver cancer. We suggest that targeted RNA base editing is well-suited to counteract liver disease by modulating protein function and upregulating hepatoprotective proteins.To maximize the likelihood of success, our team addresses three Focus Areas, each representing a distinct stage of liver disease: In Focus Area 1, we aim to modulate liver metabolism (promoting catabolism) at an early disease stage. In Focus Area 2, we seek to reduce chronic inflammatory signalling at the mid-stage. Finally, Focus Area 3 focuses on generating highly immunogenic neoantigens in cancerous liver tissue to stimulate immune therapies at advanced stages.Overall, this project will push far beyond the current state-of-the-a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Lexicalisation of Perceptual Experience' (LexPex) targeting Horizon 2020.

assistant: **Abstract**

Previous research suggests there may be underlying regularities in how languages encode perceptual experiences and in how perceptual language evolves over time. This points to the possibility that our cognitive architecture plays a role in constraining the variability in this domain of language. Substantiating this is highly relevant for the cognitive sciences, in light of recent proposals that many aspects of cognition may be more culture-specific than previously thought and that there are few, if any, universals of language. The present project takes up this goal by investigating how basic perceptual experiences (e.g. seeing, hearing, smelling) are encoded by verbs across languages and examining whether cognitive biases shape aspects of this lexical field. First, I will undertake a large-scale typological survey of perception verb lexicons to assess the extent to which they exhibit systematic patterns. Second, I will extend the search for regularities to the phylogenetic dimension, by examining whether perception verb vocabulary evolves along the same constrained pathways across three language families. Third, I will provide the first behavioural evidence to bear on the question of whether recurrent typological patterns in perception verb lexicons have their origins in cognitive biases, by conducting a novel artificial language learning experiment. This interdisciplinary project represents an ideal synergy between my research profile (linguistic typology, language change, psycholinguistics), the supervisor’s (Prof. Asifa Majid, cross-cultural psychology, word meaning) and that of the partner institution supervisor (Prof. Fiona Jordan, evolutionary and linguistic anthropology).  Through its novel contribution to lexical typology, cognitive psychology, and language evol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Implementing International Responsibility for AI in Military Practice' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The adoption of Artificial Intelligence (AI) in military practice has been famously portrayed as the third revolution in military affairs, after gunpowder and nuclear weapons. While lethal autonomous weapons might be an emerging reality, AI is already present on the battlefields, in the form of, inter alia, decision support systems and risk-assessing predictive algorithms. Just like any other means and methods of warfare, AI-based technology might (and will) lead to human rights and international humanitarian law violations. There is no consensus on the horizon regarding how, to whom and based on what principles international responsibility for such violations could be assigned, let alone implemented. This is particularly conspicuous in the European Union, where the political focus has largely been on the possible applications of AI in business and public services, while the examination of military applications is lagging behind; in fact, the core policy document on the matter, the 2020 European Commission White Paper on AI explicitly excludes “the development and use of AI for military purposes” from its scope. 'Implementing International Responsibility for AI in Military Practice' (I2 RAMP) Action fills this void through bridging theory and practice to comprehensively analyze ethical and legal challenges military AI raises, who (individuals, States or both) can be held internationally responsible and how this responsibility can be implemented with a view to produce both academic and viable operational outputs. This will be achieved by adopting an interdisciplinary approach combining, on the one hand, the Researcher’s academic knowledge of international law and hands-on experience as a military legal adviser, and on the other, the  expertise in ethics and computer scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The DNA damage response and breast cancer' in the context of a Seventh Framework call.

assistant: **Objectives**

We will exploit the DNA damage response (DDR) to assess and predict individual susceptibility and response focussed on breast cancer and breast cancer therapies. The 1st targeted therapy based on the DDR is inhibition of PARP by olaparib, which induces synthetic lethality in cancer cells with a specific DDR defect. Our members discovered olaparib, which is currently in Phase II trials. Its use in DDR deficient cancers represents a truly personalised healthcare approach. Due to the complexity of the DDR more therapeutically exploitable cases of synthetic lethality are to be discovered, which may be applied to specific tumours and patients. To this end our objectives include: To determine key differences in the DDR between cancer and normal cells, because they constitute important targets for directed individual therapy; establish the roles of DDR mechanisms as these relate to damage induced by anti-cancer therapies to explain inter-individual variation in therapy response; define how different DDR pathways compensate for one another, because this may suggest how targeting one DDR component with a drug could have marked cytotoxic effects on a cancer but not on normal cells; develop and validate markers for functionality of the DDR in fresh tumour biopsies, directly from the clinic, for selection of patients for personalised treatment.Collectively, this consortium has an unrivalled depth and breadth of expertise. We have access to a wide range of new and emerging technologies, while we bring complementary strengths to the project with regard to topics, models, materials, techniques and clinical links, which include the two largest cancer hospitals in Denmark and the Netherlands. Thus, the consortium represents the ‘state-of-the-art’ and has the scope to evolve their knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Single cell RNA-seq analysis of individual sperm cells to identify transcriptomic differences potentially involved in preferential fertilization.'.

assistant: **Objectives**

Human societies are sustained by flowering plants in different ways but especially as a key food supplier. However, it is known that increasing global temperatures strongly affect plant reproduction and the growing human population will require more food in short-middle term. Thus, to create new crop varieties more resistant to heat stress and with enhanced yield, a deeper understanding of the mechanism of plant sexual reproduction will be crucial for increasing the efficiency of plant breeding programs. Plant reproduction relies on a double fertilization process, in which two sperm cells from a pollen grain reach the ovule and one fertilize the egg cell while the other the central cell. In some species with dimorphic sperm cells a preferential fertilization of each sperm cell has been described, but for Arabidopsis thaliana as well as for many economically important crops with isomorphic sperm cells this question remains unclear. The main goal of this project is to identify by single cell RNA-seq analysis potential transcriptomic differences between the two Arabidopsis sperm cells. To do that, individual sperm cells from pollen tubes growing through female stylar transmitting tissue (semi in vivo) will be isolated by micromanipulation using a specially designed microfluidic chamber on an inverted microscope. The identification of differentially expressed genes would enable for the first time the creation of a sperm single-cell marker line to eventually explore a hypothetical preferential fertilization in Arabidopsis. These results can be adapted for plant breeding programs to develop impactful biotechnological tools, like haploid inducer lines with genetically modified sperm cells to specifically deliver components in the egg cell to induce in vivo gynogenesis. Additio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Humanitarian Passions. The Survival of Christian Iconography in Contemporary Representations of Pain: a Visual Studies Approach'.

assistant: **Concept**

My research project aims at contributing to understanding the role played by mass communications in contemporary humanitarian crises, through a comparative study of representations of pain in the history of Western iconography.The main objective is to analyse a corpus of humanitarian communications and identify their models in the history of the iconography of past centuries. Specifically, I intend to study the relationship between the images of contemporary humanitarianism and representations of the Passion in the history of Western visual arts. My hypothesis is that Christian iconography constitutes a database of images on which the media rely implicitly to create situations charged with pathos and suffering and to suggest a moral attitude to the audience.The qualifying methodology of my work is to compare images from different historical periods. Using the approach of Visual Studies I will be able to increase the knowledge of Christian iconography in the light of humanitarian communications, and to understand the effectiveness of the latter in a direct comparison with the repertoire of the Passion in Western art.The research will focus on a set of multimedia documents (NGOs campaigns, films, paintings...). The general hypothesis will be developed according to four sub-objectives: 1) To analyse the narrative, passional and axiological organisation of Christian iconography as expressed in exemplary works. 2) To analyse humanitarian communications of European catastrophes. 3) To analyse humanitarian communications concerning Africa. 4) To study Humanitarian communications as re-interpreted by contemporary artists.This research project is a significant opportunity to advance the European scientific tradition in Visual Studies. Through the achievement of the sub-objective