RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nociceptin/orphanin FQ-NOP receptor signalling and mood regulation: behavioural, pharmacological and neurochemical studies' (MOODNOP).

assistant: **Concept**

Depression is a devastating disease with high incidence and societal cost involving dysfunction of noradrenergic and serotonergic brain circuits. Current antidepressants are not ideal with less than half of the patients treated attaining complete remission using a single antidepressant whilst others exhibit partial, refractory or intolerant responses.There is a need for novel antidepressants and neuropeptides represent an interesting lead. Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) constitute a novel peptide-receptor system expressed in areas of the brain involved in emotional processing.The limited number of NOP antagonists available produce antidepressant-like effects in mice and NOP receptor knockouts display antidepressant-like phenotypes. This project is to validate the NOP receptor as an antidepressant target. In vitro assays will be employed to characterize the pharmacological profile of novel NOP antagonists.In vivo studies in rats and mice will characterize acute and chronic actions of N OP antagonist-induced effects in various models of depression. Mechanistically, interactions between monoamines and N/OFQ-NOP receptor system will be evaluated with reference to monoaminergic pathways, noradrenergic/serotonergicreceptors and monoamine release.This proposal brings together researchers with expertise both necessary and sufficient for this project which is hoped will provide evidence for NOP antagonists as a novel class of antidepressants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'On the move: Motor-cargo and motor-microtubule interactions studied with quantitative, high spatio-temporal resolution microscopy in vivo' (MOTORS).

assistant: **Concept**

Intracellular transport plays a key role in many cellular processes. Cells rely on a well-regulated, two-way transport system that consists of molecular motors and cytoskeletal filaments for their correct functioning. In nerve cells, breakdown of transport is tightly linked to neurodegenerative diseases.Understanding what goes wrong with intracellular transport during disease requires knowledge of how motors work inside cells to transport cargo. While much effort has been devoted to understanding motor mediated intracellular transport, our knowledge of motor-cargo and motor-microtubule interactions in the cellular environment is still very rudimentary. The small size of motors, the complex architecture of their microtubule tracks, and the inherently dynamic nature of transport have made these interactions virtually inaccessible to observation in living cells until recently. With new advances in fluorescence microscopy, in particular with the development of ground-breaking methods that surpass the diffraction limit, we can finally begin to address this challenging problem.In this ambitious proposal we will study, at an unprecedented level of detail, the nanoscale organization and stoichiometry of motor proteins on their cargo and interactions of motor proteins with microtubules in living cells. We will achieve this goal by using a multidisciplinary approach that combines cutting-edge biophysical tools such as single particle tracking, quantitative single molecule counting and super-resolution nanoscopy with novel genetic manipulation and fluorescence labeling methods. Using these unique set of tools we will unravel the molecular mechanisms that regulate motors to achieve efficient transport. The results obtained in this proposal will provide, for the first time, a detail
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular mechanisms, evolutionary impacts and applications of prokaryotic epigenetic-targeted immune systems' (EPICut) under Horizon 2020.

assistant: **Objectives**

Interactions between bacteria and their viruses (bacteriophages) have led to the evolution of a wide range of bacterial mechanisms to resist viral infection. The exploitation of such systems has produced true revolutions in biotechnology; firstly, the restriction-modification (RM) enzymes for genetic engineering, and secondly, CRISPR-Cas9 for gene editing. This project aims to unravel the mechanisms and consequences of prokaryotic immune systems that target covalently-modified DNA, such as base methylation, hydroxymethylation and glucosylation. Very little is known about these Type IV restriction enzymes at a mechanistic level, or about their importance to the coevolution of prokaryotic-phage communities. I propose a unique interdisciplinary approach that combines biophysical and single-molecule analysis of enzyme function, nucleoprotein structure determination, prokaryotic evolutionary ecology, and epigenome sequencing, to link the molecular mechanisms of prokaryotic defence to individual, population and community-level phenotypes. This knowledge is vital to a full understanding of how bacterial immunity influences horizontal gene transfer, including the spread of virulence or antimicrobial resistance. In addition, a deeper analysis of enzyme function will support our reengineering of these systems to produce improved restriction enzyme tools for the mapping of eukaryotic epigenetics markers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Linking the Textual Worlds of Chinese Court Theater, ca. 1600-1800', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Court theater was a core part of Chinese court and performance culture for centuries, yet its texts have never been amply studied. There are several reasons for this: their low status in Chinese literary history as ‘authorless’ performer’s texts; the vast (20,000+) quantity of texts and the difficulty of accessing them; and the lack of an existing analytic framework to study anonymous Chinese performance texts on such a large scale. Chinese court drama thus remains a ‘closed’ textual world, neglected in literary history. The lacuna is especially glaring given the quantity and richness of the extant texts: performance practices and other aspects of material culture are preserved alongside dramatic content. Furthermore, court theater was among the most ‘outward facing’ of all Chinese genres, shown to foreign ambassadors. Many visitors recorded what was often their only impression of Chinese theater culture.Chinese court theater thus contains a complex series of closed, disjointed textual worlds. To re-link these textual worlds, this project will build the first digital archive of court drama scripts and related foreign records. Based on this resource, the project will trace internal links between scripts in the textual web of court drama; draw external links to individuals, occasions, and artefacts; and consider cross-cultural links to situate Chinese court drama in its global context.The project will produce the first textual studies of Chinese court drama, including a court drama textual database, a series of monographs and publications on extended text-based research topics, and an anthology of English translations for the general reader. These outputs will remedy the lack of textual studies on Chinese court drama, contributing towards our understanding of Chinese thea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development and Application of a New Class of Halogenated Reagents to Commercially Valuable Targets'.

assistant: **Objectives**

The aim of this project is to expand upon a newly discovered platform reaction by developing new routes to Active Pharmaceutical Ingredients (APIs) Tolterodine and Ezetimibe and other advanced intermediates for the manufacture of drugs (i.e. benzylic fluorides and alcohols).  It is planned that this platform will serve to enhance the competitveness of the European pharmaceutical manufacturing industry as it continues to face increased competition from other economiesIn order to achieve this aim we need to bring together expertise in(i)Organic Synthesis [Royal College of Surgeons in Ireland, “RCSI”](ii)Enantioselective fluorination [Nagoya University Japan, “Nagoya”](iii)Drug development and production [Integrated Research in Biotechnology & Medicine, “IRBM”]To meet the aim we have divided the project into the following work packages:WP1: Development of a new synthesis of Tolterodine.WP2: Scale up of synthesis of Tolterodine. WP3: Development of a new synthesis of Ezetimibe.  WP4: Scale up of synthesis of Ezetimibe.WP5: Exemplification of alkoxylation to prepare enantiopure benzylic alcohols API intermediatesWP6: Preparation of benzylic fluoridesWP7: Management, Training, Dissemination & Communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Customer-driven rail-freight services on a European mega-corridor based on advanced business and operating models' to be submitted under Sixth Framework.

assistant: **Abstract**

The CREAM Project has been designed to respond to the increasing demand for rail-based logistic systems, and the implementation of change in the European railway area, which has been initiated by the European legislation. Against the benchmarking business models of logistic service providers CREAM will design and validate advanced customer-driven business models for railway undertakings and intermodal operators.CREAM will analyze the operational and logistic prerequisites for developing, setting up and demonstrating seamless rail freight and intermodal rail/road and rail/short sea/road services on the Trans-European mega-corridor between the Benelux countries and Turkey, including field validation.CREAM is committed to develop business cases, which will be integrated into an innovative corridor-related freight service concept, with respect to:- Innovative rail-based supply chains including intelligent rail and multimodal operation models- Quality management system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Bio-inspired catalysis in aqueous coacervate droplets: towards a softer chemistry'.

assistant: **Objectives**

Bio-inspired catalysis in aqueous coacervate droplets: towards a softer chemistryRecent advancements in modern synthetic chemistry have aligned with the imperative of reducing environmental impact, driving the emergence of a more sustainable chemistry, inspired by nature. In organic chemistry, the formation of C-C bonds is pivotal but often necessitates the use of both metal and organic solvents. However, a non-enzymatic approach to forge C-C bonds in water has been demonstrated through the Stetter reaction, a bio-inspired process catalyzed by N-heterocyclic carbenes (NHC) and thiamin cofactor mimics. Due to their limited water solubility, organic substrates generate water-isolated organic droplets, effectively promoting the Stetter reaction despite NHC's sensitivity to hydrolysis. Our objective is to investigate the Stetter reaction within polymer-rich aqueous microdroplets known as ""coacervates,"" which emulate primitive models of early living cells. Similar to micellar chemistry, these droplets possess a hydrophobic inner core, facilitating the spontaneous uptake and accumulation of organic molecules. We hypothesize that coacervates can serve as microreactors for C-C bond synthesis, catalyzed by newly designed azolium-based organocatalysts compatible with coacervates. Our aim is to demonstrate in-situ C-C bond formation via a model Stetter reaction and explore the molecular mechanism, akin to an ""on-water"" environment, while considering the impact of coacervates' internal polarity on reaction kinetics, yield, and selectivity. Altogether, our findings will broaden horizons in sustainable bio-inspired chemistry, enhancing the soft chemistry toolbox and potentially inaugurating a new realm of research: bio-inspired organic synthesis within coacervates. Significantly,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Predictive and adaptative algorithms for Smart cities, HR and Finance Industries' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Braincities wants to build a human Supportive Artificial Intelligence (hSAI) with judging and empathy capabilities by using the latest advances in Deep Machine Learning technologies. The idea is to create a context-aware recommendation system to scan, analyse and match patterns, supporting Human Resources, Smart Cities and finance industries with better guidance powered by AI.This design is based on the concepts of Actionable AI, Steady States Analytics, Natural Language Processing and AI-based time series operating over a Decentralised Blockchain Big Data storage system.Braincities has been supported by sponsors, partners and start-up accelerators that are conscious that a great amount of research is needed to plot, construct, test and implement the architecture, logic and training methods of the several Artificial Neural Network algorithms needed to such complex system. To accomplish this, the hSAI has been split into several independent smart layers in order to fulfil specific demands or ‘use cases’ for different allied companies. With Porsche (Stuttgart), the idea is to build a career planning tool adapted for personal planning and based on employees CVs and personal statements. With Careaway we will mine patients habits and emotional steady states to help doctors perform better diagnosis and monitor the overall evolution of the patient.An alliance with Bita Index (Frankfurt) is made to build an AI model ‘able to predict the stock market behaviour’ using stocks and social media data.The research and innovation required for each individual application, and the integration of them into the final system, is expected to be done by an experienced researcher with diverse skills who at the same time should be open to perform several advanced trainings to improve and divers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SOlar Open Community Instruments for All Residents in Europe and the Mediterranean region' under Horizon Europe.

assistant: **Concept**

The transition to renewable energy, particularly through the widespread adoption of distributed solar PV systems, is hindered by significant technical, social, financial, and regulatory barriers. Key challenges include energy poverty and inequality, especially in Mediterranean regions where inefficient housing and rental systems exacerbate the issue. Limited awareness, bureaucratic hurdles, and inadequate financial incentives further slow adoption, while integrating decentralized renewable energy into existing communities remains complex. Unlocking the full potential of Renewable Energy Communities (RECs) requires clear benefits, accessible financial tools, and innovative technologies to enhance the efficiency and longevity of PV systems.SOCIAREM will accelerate the adoption and profitability of PV systems within RECs by overcoming these barriers through an innovative, implementable solution integrated with collective self-consumption schemes. The project will develop advanced tools tailored to diverse socio-economic and geographical contexts, enhancing efficiency, minimizing energy losses, and maximizing renewable energy use. Blockchain-enabled platforms will facilitate secure, decentralized peer-to-peer energy sharing, improving energy autonomy and resilience. Inclusive social data spaces will ensure fair energy distribution while safeguarding privacy, addressing energy vulnerability, and promoting social equity. Citizen engagement will be fostered through gamification and educational tools, ensuring participation across different cultural and behavioural profiles. A consortium of universities, R&D centres, and companies will drive SOCIAREM’s development, ensuring strong scientific and market expertise. The project’s solutions will be tested in four European RECs—Swit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Constitutional Place of Expertise' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project explores how constitutional principles can enhance the democratic legitimacy of expert-based decision-making in the European Union (EU). It does so by focusing on participation, transparency and administrative rationality, as interpreted by European Courts when reviewing expert-based decisions, and as incorporated into institutional practices involving both scientific and economic expertise. In particular, CONPLEX aims at detecting links and influences between Courts’ activity and decision-making processes, capable of leading to a deeper integration of expertise within the constitutional discourse. The proposal draws on a new legal realist approach to legal research, and combines doctrinal analysis of the Courts’ case-law and empirical investigation of institutional practices – through documentary analysis and semi-structured interviews to Commission’s officials and experts. The project is original from a conceptual, methodological and empirical perspective and makes a timely contribution to the on-going debate on technocracy and democracy in the EU, especially with regard to the role played by scientific and economic experts in politically controversial issues.The research will take place at the Faculty of Law of the University of Amsterdam (UvA), and will be embedded in the research programme of the Amsterdam Centre for European Law and Governance (ACELG). It will be co-supervised by Prof. C. Eckes and Dr. M. Weimer, who are leading experts in the field of EU constitutional law and EU law and governance. Besides enhancing my scientific knowledge and research skills, my international research network and my profile as an independent researcher – thereby improving my career opportunities – the project will contribute to European research excellence and to ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Resolving the debate on a permanent El Niño-like state in the late Miocene: establishing equatorial Pacific conditions, driving forces and global impacts.'.

assistant: **Innovation**

A key dispute in palaeoclimate research is whether or not a permanent El Niño-like state, with warm waters spreading across the equatorial Pacific, existed during the late Miocene. Late Miocene climate was similar to the 4°C warming predicted for 2100 by the IPCC. As today’s El Niño causes global climate anomalies, a permanent El Niño-like state in the past may have had serious, global consequences, such as widespread aridity. MIONIÑO will test the existence of a late Miocene permanent El Niño-like state using geochemical microfossil records from recently recovered Western Pacific Warm Pool (WPWP) sediments and earth system modelling to assess equatorial Pacific conditions, their driving forces and global impacts.MIONIÑO is timely, only being possible since the recovery of crucial WPWP samples in late 2016. MIONIÑO is also original and novel, presenting a new template for solving complicated climate questions using a new, robust stratigraphy and an interdisciplinary approach. UCL Earth Sciences is the ideal location to pursue state-of-the-art research in palaeoceanography and stratigraphy. Combining my existing expertise with key specialist knowledge from UCL researchers will equip me with the required skills to successfully complete MIONIÑO. I can hone my research vision and gain transferable skills to help me achieve my ultimate career goal of an academic research position.MIONIÑO will advance past and future climate change research. Resolving the debate on permanent El Niño-like conditions in the late Miocene will discern whether warm El Niño events, as occurred in 2015/2016, become more frequent or evolve into a new mean state. Assessing causal links between permanent El Niño-like conditions and increased continental aridity will improve the future climate models th