RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Modeling Prey Isocapes in the North Atlantic for Advancement in Predator Ecology'.

assistant: **Concept**

The immensity of the oceans makes it difficult to monitor them at a spatio-temporal scale that is relevant for resolving ecological processes and responses to decades of pressure from multiple anthropological stressors. With IsoMod, I aim to map the biogeochemical tracers (stable isotope (SI) composition) at the base of the food web to inform three key measures of marine ecosystem processes that might be affected by these stressors: productivity, food web structure and animal migration pathways. The isoscapes will be developed at the scale of the North Atlantic Ocean and will be based on Calanus spp. carbon and nitrogen SI values, δ13C and δ15N. Lipid rich zooplankton organisms such as C. finmarchicus fuel a large part of the higher trophic level in the North Atlantic, including many species of fish, birds and mammals. I will use a recently developed spatial statistic approach where high resolution observational data (e.g., satellite data) are applied as predictors of SI variability, and apply these models to produce isoscapes with a full coverage of the study area. The application of these isoscapes will be showcased in two case studies. The first will test the role of changes in Atlantic puffin (Fratercula arctica) winter diet in key life-history parameters (e.g., body condition, survival rate). Specifically, the isoscapes will be used to provide the trophic baseline needed to investigate changes in puffin trophic position associated with changes in diet. The second case study will use prey SI to improve forecast of Northeast Atlantic mackerel (Scomber scombrus) summer distribution. Variation in SI values can be linked to variation in secondary productivity and this will be used to identify best foraging conditions for mackerel ahead of their migration to the summer f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Valorising the straw waste stream through a novel bio-mechanical process which converts 100% of the waste into three high value products including bleached paper pulp.'.

assistant: **Objectives**

Currently paper pulp is made mainly from either wood or recycled paper, however this has placed a huge burden on forests with deforestation still alarmingly high in many parts of the world.Pulping straw (a low to no value by-product of the wheat industry) to make paper pulp appears to be the perfect solution. However this process produces a black liquor with no viable economic disposal solution for small-scale production. The process cannot achieve reasonable running costs (heat, pressure, chemical renewal), requires dry straw, uses expensive recovery techniques and requires skilled workers to operate the digester.ECOPULPING is an alternative processing method enabled by corresponding novel equipment design. This process in turn enables much easier and more efficient processing and 100% valorisation of the process output. Our novel ECOPULPING process does not require any pressure and very low heating meaning low running costs and which simplifies the recovery treatments and requires less costly materials. This leads allows access to valuable co-products which will be worth up to or more than twice the value of output when compared to current pulping mills and produces no liquid waste or odour. The plant is designed to operate as a closed-loop system meaning that there is little chemical top up needed. It can use straw with high moisture content and therefore there are no storage costs.We have already built a pilot plant capable of producing 400 kg per day of unbleached and un-cleaned pulp, and soon a cleaner pulp in the UK. The plant is successfully being used to process pre-production samples for prospective partners using paper mills to finish the paper products.The overall first objective for the ECOPULPING project is to build a 50 tonne bleached straw pulp a day dem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Voltage-Controlled Electronic and Magnetic Phase Transitions in Nano-Devices based on Correlated Mott Materials' (VOLTEMAG) targeting Horizon Europe.

assistant: **Abstract**

Matter can exhibit a complicated phase diagram comprising a large number of different electronic and magnetic states. While phase transitions induced by temperature or pressure variations, doping, and optical pulses have primarily been studied in bulk materials, phase transitions driven by a bias voltage in nano-devices are mostly unexplored.VOLTEMAG will demonstrate how different electronic and magnetic phases can be tuned through the application of a bias voltage when a material is incorporated into a two-terminal nano-device, especially in the case of materials from the strongly correlated oxides family. The researcher Dr. Anita Halder guided by Prof. S. Sanvito and Dr. A. Droghetti at Trinity College Dublin (Ireland) will develop and use a solid theoretical approach based on the Non-Equilibrium Greens functions, Density Functional Theory and Dynamical Mean-Field Theory to predict and establish the fundamental physics of voltage-induced magnetic (ferromagnetic-antiferromagnetic) as well as electronic (metal-insulator) transitions. Devices relying on electronic phase transitions behave as multi-state transistors and resistive switches, which are currently the key hardware components to implement neuromorphic computers. The results of VOLTEMAG may therefore lead to possible technological developments, apart from their fundamental character. VOLTEMAG will then set up an extended search for new optimal materials for potential applications via machine learning algorithms.VOLTEMAG will merge the researchers background in materials modeling with the expertise of the host institution in quantum theory for nano-devices. The applicant will be trained on several theoretical and computational techniques essential for her future scientific career. She will be able to expand her s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Paradoxical activation of oncogenic signaling as a cancer treatment strategy.' (PARADOX).

assistant: **Innovation**

Cancer cell homeostasis requires a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress-response programs to counteract the inherent toxicity of such aberrant signaling. Indeed, emerging evidence suggests that hyperactivated oncogenic signaling can also be toxic to cancer cells, indicating that cancer cells select optimal levels of oncogenic signaling rather than maximal levels. I propose here a fundamentally different approach to the treatment of cancer, based on deliberate hyperactivation of oncogenic signaling, combined with perturbation of the activated stress responses to selectively kill cancer cells. We will use drugs that further activate oncogenic signaling in cancer cells (protein phosphatase 2A (PP2A) inhibitors, GSK3 inhibitors, PKC activators, DUSP inhibitors) and study the associated toxicities using single cell omics technologies. We will then use CRISPR and compound screens to identify the vulnerabilities of such drug-treated cells. This will identify effective combination therapies using this paradoxical approach. We have delivered initial proof of concept for this notion by demonstrating that hyper-activation of oncogenic signaling in colon cancer by small molecule inhibition of PP2A, combined with inhibition of the mitotic kinase WEE1 results in dramatic anti-tumor responses in vivo. Most strikingly, we found that cancer cells develop resistance to this therapy through selective downregulation of oncogenic signaling to evade the stress imposed by hyperactivation of oncogenic signaling. Consequently, resistance to this hyperactivation therapy was associated with both reduced oncogenic signaling and oncogenic traits in vivo. Here, we aim to understand and exploit toxicities associated with paradoxical activation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Characterization of streptococcal vaccine antigens' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The host institute is the research arm of Chiron Vaccines. Based in Siena, Italy, the host specializes in the research and development of novel vaccines. A genomic approach has been taken at the host institute to identify several novel candidate antigens f or vaccines against the Gram-positive pathogens Streptococcus agalactiae (Group B Streptococcus) and Streptococcus pyogenes (Group AStreptococcus). The next steps in the program are to take the antigens on the path through development to possible human cli nical evaluation and in parallel to characterize the antigens with respect to structure, function and their mechanism of conferring protection. While the host institute has extensive expertise in pathogenesis and vaccine design against Gram-negative pathog ens, it lacks specific experience in the microbial genetics and pathogenesis of Gram-positive bacteria. This contract aims to address this lack by permitting experienced microbiologists with a background in Gram-positive pathogenesis to carry out cutting e dge research in an active vaccine institute. The resulting transfer of knowledge to the institute is essential to expand the host's activities to a range of pathogens outwith itscurrent expertise. Four experienced researchers (4-10 years postgraduate) will be recruited, each for a two-year period, over a period of three years. The researchers will be recruited from European laboratories with expertise in the field of pathogenesis of Gram-positive bacteria. Europe has a strong background in this area of rese arch and there are many laboratories carrying out high quality research relevant to the project. The transfer of knowledge from the recruited researchers will increase the competitivity of the research of the host and will facilitate the development of new pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Proteomic explanations for the adaptive significance of kin recognition in subsocial spiders' in the context of a Seventh Framework call.

assistant: **Objectives**

Kin selection theory predicts that cooperation should evolve among kin to reduce the costs of helping and the incentive to cheat. Altruistic behaviour provides individuals with either direct or indirect fitness benefits. As a necessary prerequisite, individuals need to recognise kin to direct their help towards them. Thus, kin recognition is a key feature of many social animals. Ultimate benefits of altruism are well studied, but proximate mechanisms explaining the maintenance and early evolution of kin recognition are still poorly understood. Social spiders provide an intriguing model system to investigate this issue, as some species show kin recognition but a less pronounced complexity of social interactions than that of eusocial insects. Social spiders only hunt and feed communally. Groups of close relatives perform better resulting in a higher individual fitness. Behavioural differences do not explain the better performance. Using proteomic analyses, this project will explore the possibility that a kin-specific investment in the extra-oral digestion and/or a kin-specific compatibility of the digestive enzymes is/are responsible for the better performance of related spiders. Our study object will be the sub-social spider Stegodyphus lineatus (Eresidae) in which kin recognition has been found. This species is an excellent study organism to help resolving one of the long-lasting questions in evolutionary biology, how cooperation can be evolutionarily stable.We will apply different proteomic analyses to identify the enzymatic compounds of the spiders’ digestive fluids and compare their relative composition among related and unrelated individuals. As the genome of our study species has recently been sequenced we will compare the diversity of proteins with the diversity o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Demonstration of maternal effects of Atlantic cod: combining the use of unique mesocosm and novel molecular techniques' under Fifth Framework.

assistant: **Concept**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe main objectives are:1. To examine the viability of offspring from recruit (first-time) female spawners compared to offspring from repeat (elder) female spawners of Atlantic cod.2. To examine variations in viability between offspring of individual pairs of cod.3. To analyse the demographic structure (age-, sex- and maturity armature) of selected European cod stocks by means of historical data sets.4. Based on the results of objectives 1., 2. and 3., to evaluate the possible effects on cod recruitment and implications for fishery management.The first two points will be examined by employing rearing experiments in large marine enclosures (mesocosms: 2500 & 4400 m3) and comparing measures of viability between individual offspring originating from first-time and second-time spawning females. Such differences will be compared with variation that occurs between parents within each group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Natural nEUROactive Mechanical mETAmaterials' (NEUROMETA) targeting Horizon 2020.

assistant: **Abstract**

Metamaterials with anomalous and counter-intuitive multiphysics behaviours have been developed during the last two decades to help communication systems, sensing and robotics. Paradigmatic developments in artificial intelligence, Digital Twin approaches and additive manufacturing are pushing the design and production of metamaterials also towards the development artificial equivalent of synapsis and programmability. These advanced metamaterial concepts are however fossil-based and tend to make use of materials with a high carbon footprint and heavy life cycle costs in terms of emissions and environmental sustainability. Sensing/actuation mechanisms are also innate in natural plant fibres, spider silk strands and enzymatic systems, and involve saturation, hygromorphism, piezoelectricity and controlled hysteresis that could provide similar synaptic behaviours. Programmable memory properties could also be mechanically created in solid matter, and similar mnemonic-type architectures abound in natural fibres and related composites. While neurogenesis in electromagnetic metamaterials is at early stages of development, no neuroactive mechanical metamaterial concept and design based on biobased materials has been developed so far. The project aims at developing this paradigmatic new class of metamaterials. We will explore the use of natural fibre composites, bio-based matrices, spider silk strands, 3D printing of bioblock materials and natural piezoelectricity in wood/cellulose combined with metamaterial architectures to develop artificial bio-based and sustainable surrogates of programmable memory with learning/adaptive behaviours similar to artificial neural networks. These metamaterials will autonomously learn from their past loading history and generate resilience in the st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Selective Wavelength-Induced Targeted Control of DNA-Homo G4s' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Guanine-rich (G-rich) oligonucleotides can fold into G-Quadruplexes (G4s), four-stranded DNA structures involved in the fine regulation of key cellular processes. G4s are found in telomeres, oncogene promoters (kRAS, cMYC, BCL2), and non-coding RNA, where they likely play important roles in transcription and translation. Despite extensive research, the precise regulatory function of G4s remains unclear, and key questions  such as whether G4 formation actively drives gene expression or is a byproduct of it  are still unresolved. A significant limitation to advancing this understanding is the lack of chemical tools that offer the temporal and spatial control necessary for studying G4 dynamics in living cells. This proposal aims to address this challenge by developing a light-responsive tool that enables precise temporal control of G4 folding in relevant promotor region, in living cells. By using UV/visible light as an external trigger, this tool will allow dynamic studies on the effects of G4 formation on gene expression, offering the possibility of controlling the secondary structure folding on-demand. The core of this approach is the synthesis of light-responsive DNA primers, which will be incorporated into photo-responsive plasmids via NEEL, a novel plasmid resynthesis method. The modifications introduced are designed to dynamically favor or inhibit the formation of stable G4 structures by manipulating the assembly of G-tetradsthe core element required for G4 folding. The tool, SWITCH-G4, will be validated using the cKIT promoter model and then expanded to study other G4-forming promoters, such as kRAS, cMYC, and VEGF. This project will provide unprecedented spatial and temporal resolution in the study of G4s, advancing our understanding of their regulatory roles in ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamics and Predictability of the ENSO teleconnection to the Tropical North Atlantic', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This proposal aims at exploring the El Niño-Southern Oscillation (ENSO) influence on the tropical North Atlantic (TNA) sea surface temperature (SST). The SST variability in the TNA region has been observed to affect weather and climate in surrounding areas, including European heat waves, tropical Atlantic hurricane activity, the West African monsoon, and rainfall over north-eastern Brazil. Fishery production in the subtropical Atlantic is, likewise, closely related to TNA SST anomalies. Hence, better understanding the predictability sources of the TNA SST variability is of major relevance, not only for the climate forecasting community but also for different socio-economic sectors.The scientific objective of this project is to advance understanding of the simulation and prediction of TNA SST at seasonal-to-interannual timescales. The main goals are to gain insight into the dynamical mechanisms at work, and to assess the ability of current seasonal forecast systems in representing the ENSO-TNA remote connection. Climate model deficiencies and biases, which lead to uncertainties in their forecasts, will also be addressed. Concrete plans for society outreach, enabling the impact and dissemination of results, will be undertaken in a targeted work-package. The novelties of this project are (i) the evaluation of a new teleconnection mechanism to explain the timing of the intertropical relationship, (ii) the assessment of the ENSO contribution to SST skill over the TNA region, and (iii) the use of the most complete set to date of operational seasonal forecast systems. The latter, in particular, ensures that the outcomes derived from this fellowship will contribute to meet users’ needs.