RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Controlling the orientation of molecules inside liquid helium nanodroplets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In this project I will develop and exploit experimental methods, based on short and intense laser pulses, to control the spatial orientation of molecules dissolved in liquid helium nanodroplets. This idea is, so far, completely unexplored but it has the potential to open a multitude of new opportunities in physics and chemistry. The main objectives are:1) Complete control and real time monitoring of molecular rotation inside liquid helium droplets, exploring superfluidity of the droplets, the possible formation of quantum vortices, and rotational dephasing due to interaction of the dissolved molecules with the He solvent.2) Ultrafast imaging of molecules undergoing chemical reaction dynamics inside liquid helium droplets, exploring rapid energy dissipation from reacting molecules to the helium solvent, transition between mirror forms of chiral molecules, strong laser field processes in He-solvated molecules, and structure determination of non crystalizable proteins by electron or x-ray diffraction.I will achieve the objectives by combining liquid helium droplet technology, ultrafast laser pulse methods and advanced electron and ion imaging detection. The experiments will both rely on existing apparatus in my laboratories and on new vacuum and laser equipment to be set up during the project.The ability to control how molecules are turned in space is of fundamental importance because interactions of molecules with other molecules, atoms or radiation depend on their spatial orientation. For isolated molecules in the gas phase laser based methods, developed over the past 12 years, now enable very refined and precise control over the spatial orientation of molecules. By contrast, orientational control of molecules in solution has not been demonstrated despite the potential o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Delivering Alien Invasive Species Inventories for Europe' (DAISIE), addressing dissemination and exploitation.

assistant: **Impact**

Effective control of invasive alien species has been hampered by:a) the lack of monitoring for alien species at frequent enough intervals in regions of concern;b) a means to report, verify the identifications, and warn of new sightings; andc) risk assessments that predict the likelihood of a particular species becoming invasive. Europe has yet to establish a programme with the primary goal of detection, quantifying the possible risk, and warning managers before a respective alien species spreads beyond its point of initial introduction. Such a programmes should provide:a warning system to alert regional managersan inventory of alien species against which invasive alien species can be determined,a European information dissemination system,an early detection and monitoring system for alien speciesIn response to these requirements, DAISIE will deliver a European one-stop-shop" for information on biological invasions in Europe. It will bring together:The European Alien Species Expertise Registry: a directory of researchers and research European Alien Species Database: including all known naturalized alien species in Europe European Invasive Alien Species Information System: descriptions of all naturalized alien species known to be invasive in Europe Species Distribution Maps and Spatial Analysis: Distribution maps of all invasive alien species in Europe known or suspected of having environmental or economic impacts.DAISIE will be a pivotal instrument in developing a Europe-wide strategy that encompasses both the geographical scale of the problemand unites the study of different taxa in marine, freshwater and terrestrial environments. DAISIE will address the need for a regional network of invasive alien species information."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Application of Silicon Photomultipliers to Imaging Detectors' (ASPID) targeting Seventh Framework.

assistant: **Abstract**

Medical imaging is a multidisciplinary research field that has a direct application to the improvement of human health. Instrumentation development in this area is an essential step in the search for high performance imaging devices that can help to provide an early and accurate diagnosis of the diseases. The novel photodetectors known as silicon photomultipliers or multicell Geiger-mode avalanche photodiodes are an alternative to the traditional photomultiplier tubes that can overcome some of the limitations of the existing instrumentation. In the last years they have reached a performance level that can make their application to medical imaging highly advantageous. The use of these photodetectors makes possible the construction of high resolution and efficiency detector blocks that can lead to a significant improvement in the performance of detectors for Positron Emission Tomography (PET).The proposed project aims to contribute to the development of this technology and to assess its benefits in medical imaging through their employ in the construction of detector heads for two different applications: a small animal PET scanner with expected submillimeter spatial resolution and a clinical high resolution intra-operative PET probe. The project will greatly help the applicant in her reintegration process in the host institution, to continue her training as a scientist and further improve her management and leadership abilities, and also to get established and consolidate her research career. Furthermore, it will serve to reinforce the collaboration with the host institution of her previous Marie Curie Intra-European fellowship, and will also contribute to introduce this novel and promising technology in the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multipoint Optical DEvices for Minimally invasive neural circuits interface' (MODEM), addressing dissemination and exploitation.

assistant: **Impact**

A primary goal of experimental neuroscience is to dissect the neural microcircuitry underlying brain function, ultimately to link specific neural circuits to behavior. There is widespread agreement that innovative new research tools are required to better understand the incredible structural and functional complexity of the brain. To this aim, optical techniques based on genetically encoded neural activity indicators and actuators have represented a revolution for experimental neuroscience, allowing genetic targeting of specific classes of neurons and brain circuits. However, for optical approaches to reach their full potential, we need new generations of devices better able to interface with the extreme complexity and diversity of brain topology and connectivity.This project aspires to develop innovative technologies for multipoint optical neural interfacing with the mammalian brain in vivo. The limitations of the current state-of-the-art will be surmounted by developing a radically new approach for modal multiplexing and de-multiplexing of light into a single, thin, minimally invasive tapered optical fiber serving as a carrier for multipoint signals to and from the brain. This will be achieved through nano- and micro-structuring of the taper edge, capitalizing on the photonic properties of the tapered waveguide to precisely control light delivery and collection in vivo. This general approach will propel the development of innovative new nano- and micro-photonic devices for studying the living brain.The main objectives of the proposals are: 1) Development of minimally invasive technologies for versatile, user-defined optogenetic control over deep brain regions; 2) Development of fully integrated high signal-to- noise-ratio optrodes; 3) Development of minimally invasive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Alcoc' under Fifth Framework.

assistant: **Concept**

The objectives of the proposed events are three in number: (a) to give initial competence to a total of one hundred students and workers in the language industries in the handling of language corpora; (b) to focus on the relevance of this competence in a number of applications, in particular translation, language teaching, lexicography and literary study; (c) to bring representatives from the academic and commercial wings of language, applications to work together. The impetus for this application is the urgency of the need for key actors, particularly young researchers, to acquire competence and confidence in working with corpora.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Violent settlements: strategic villages and clandestine burial sites in Latin America' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In contemporary warfare the power to destroy cities exists alongside with the power to built urban places ex nihilo. In the 70s and 80s, various Latin American States forcedly displaced people to villages created as an instrument of counterinsurgency; at the same time massacres and forced disappearances occurred in these regions. How does the simultaneous creation of strategic villages and clandestine burial sites affect the ways of inhabiting and imagining space in the aftermath of political violence? My study aims at analysing for the first time the connexion between mass violence and the forced creation of built environment. Based on qualitative fieldwork undertaken in Tucumán (Argentina) and Ayacucho (Peru) and framed within social anthropology, sociology and human geography, this research will produce a seminal in-depth study of the daily life among the strategic villages in Latin America, by analysing the experience of subjects that were forced to inhabit there.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Synthesis of antimitotic agents related to rhazinilam'.

assistant: **Concept**

Research objectives and content Synthesis and structure-activity relashionship of rhazinilam and analogs. The project will focus on the biaryl structural element of the natural product. A strategy involvino heterocouplinn of two highly functionalised aromatics will be used. This strategy is meant to be used in a combinatorial approach on a so- lid support. The biological evaluation will be done by the researchers of Rhtne- Poulenc Porer in Paris. With these data in hands we hope to be able not only to design better analogs but to understand the mode of action of rhazinilam which is still under debate. Also this project will require to develop new practical routes towards heterobiaryls and will help the project of total synthesis of rhazinilam itself which is presently studied in Ghosez's laboratory. Training content (objective, benefit and expected impact) The objective is to train a Ph.D. student in the field of organic synthesis. This project is particularly interesting inasmuch as it involves synthetic methodolo- gy, combinatorial synthesis and structure-activity relationships. Links with industry / industrial relevance The link will be strong because the biology will be done in industry. Obviously this fundamental research project is a great interest for the pharmaceutical industry because rhazinilam acts as an antimitotic agent like taxol and taxotere which are powerful anticancer agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Strong electron-photon interactions with high-Q microresonators' (SEPhIM) targeting Horizon 2020.

assistant: **Abstract**

The main objective of the SEPhIM research action is the development and exploitation of strong electron-photon interactions with photonic-chip-based high-Q microresonators and photo-induced near-field electron microscopy (PINEM). This will be achieved using the ultra-high quality factor of integrated microresonators to enhance the coupling strength between free electrons and cavity photons in an ultrafast transmission electron microscope (UTEM). This project will bridge and separately advance the fields of integrated photonics, ultrafast electron microscopy, and quantum optics.By performing UTEM-PINEM, a multidimensional imaging and spectroscopy of the microresonators are available. The enhanced electron-photon interaction, mediated by the high Q-factor of the microresonators, will lead to a strong phase modulation of free electrons, a wide spectral broadening of the electron energy, and the measurement of cavity-photon lifetime. Moreover, using temporal dissipative solitons formed in the microresonators, time-gated electron-soliton interactions will also be investigated. Due to the strong spatiotemporal confinement of the soliton pulse, the electron-photon coupling will be further enhanced. Attosecond electron pulses in UTEM will enable time-domain electron microscopy of the soliton waveforms, while the concomitant generation of optical frequency combs will provide spectrally-resolved characterization of the electron-soliton interaction. Furthermore, strong coupling between free electrons and cavity photons will enable quantum state synthesis and entanglement generation. As a proof-of-concept demonstration, we intend to perform all-optical non-demolition detection of free electrons. The electron-photon interaction will be used to herald and register transmitted electro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Cosmological and phenomenological studies of string theory'.

assistant: **Concept**

String theory is for the moment a unique candidate for a consistent unification of gravity with gauge interactions but it lacks experimental evidence. Given the multitude of possible ways of compactifying string theory from ten to four dimensions, it then becomes very difficult to find the compactification that will correspond in the low energy limit to the Standard Model.One aim of the project is to make advances in understanding the way in which the Standard Model is possibly embedded as a low-energy limit in string theory by finding models that are closer to its properties. Our effort will concentrate in ameliorating the low energy models obtained by orientifold compactifications and a special attention will be devoted to the current and future accelerator and cosmological data and the constraints for model building that they can provide.Secondly we intend to address cosmological issues (time dependent solutions, moduli stabilization) in the context of realistic models. To this end, compactifications of type II strings with various fluxes in the internal manifold and, in particular, the case of fluxes leading to branes intersecting at angles, recently investigated, will be studied further and included in the string model building program presented above, in addition to more traditional non-perturbative phenomena as gaugino condensation in a hidden sector. Models with internal fluxes are also convenient to study the issue of tadpole resummations in a quantitative fashion.This project will allow the candid ate to gain complementary knowledge in closely related fields to string theory, like particle physics and cosmology. At the same time the proposed project can contribute to consolidate the position of the European string theory community as a reference point in the a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of the ph-domain in regulating pdk1 activity' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

I propose to generate a PDK1 knocking mouse embryonic stem cell line that expresses a mutated form of DKP1 which PH-domain can not interact with PtdIns (3,4,5)P3. The study of this cell line will permit to further understand the mechanism by which PtdIns(3,4,5)P_3 regulates the insulin signal transduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pan-european assessment, monitoring, and mitigation Of Stressors on the Health of BEEs'.

assistant: **Concept**

Bees – honey bees, bumble bees, and solitary bees – pollinate our crops and wildflowers, and thus are essential for human well-being. However, in Europe, and around the globe, bees face many threats and are often in decline as a result. One potential driver of reduced bee health is agrochemicals. While laboratory and semi-field studies suggest that such chemicals negatively impact bee health, their importance and relevance in the real world remains unclear. PoshBee is a consortium of academics, governmental organisations, industry, and NGOs that will address the issue of agrochemicals to ensure the sustainable health of bees and their pollination services in Europe. Integrating the knowledge and experience of local beekeeping and farming organisations and academic researchers (including the EU RefLab for bee health), we will provide the first comprehensive pan-European assessment of the exposure hazard of chemicals, their mixtures, and co-occurrence with pathogens and nutritional stress for solitary, bumble, and honey bees across two major cropping systems. Integrated studies across the lab-to-field axis will determine the effect of chemicals, their mixtures, and interactions with pathogens and nutrition on bee health. We will combine the skills of commercial bumble bee and solitary bee producers, ecotoxicological industry, and academics to develop new model species and innovative protocols for testing chemicals in bees. With MUST-B, we will integrate this information to develop dynamic landscape environmental risk assessment models for bees. Using proteomics, we will produce new molecular markers for assessing bee health and enabling long-term monitoring schemes. Finally, combining across our partners and stakeholder board, we will deliver practice- and policy-relevant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deletion by hymologous recombination - knock-out - of regulatory regions which determine the subset specific expression of the cd8 gene' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The CD8 molecule is absent from early thymocytes (CD4-8-), it appears on the cell surface along with CD4 in the intermediate stage of double positive (CD4+8+) and its expression is extinguished in the CD4+ and retained in the CD8+ mature T cells. In order to identify the sequences within the CD8 gene locus which regulate this complex pattern of expression the CD8alpha and beta genes have been cloned and putative regulatory DNaseI hypersensitive regions have been identified. We propose to generate transgenic mice carrying reporter genes under the control of such regulatory sequences in order to identify their role in the CD8 subset specific expression and consequently in the differentiation of mature cytotoxic cells. In parallel selected areas from these regulatory regions will be deleted (consititutively or inducibly) from the endogenous locus using homologous recombination techniques. Such a dual approach is expected to dissect the molecular mechanisms which underlie the regulation of expression of the CD8 molecule and the commitment to the cytotoxic T cell lineage. Training content (objective, benefit and expected impact) The candidate will be trained in a wide range of molecular biology techniques such as cloning, sequencing, DNA and RNA hybridisation, transgenic and knock-out technology. In addition, the candidate will be trained in a variety of immunological assays such as cytotoxic and proliferation assays, fluorescence activated sorting etc. The project will generate information which is central in understanding thymocyte development and lineage commitment. The identification of sequences which selectively direct the expression of genes in the CD8 compartment of the immune system will be useful in a variety of experimental systems