RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GENOMIC TOOLS FOR BREEDING AGAINST HERITABLE DISEASES IN HORSES' in the context of a Seventh Framework call.

assistant: **Objectives**

The project will use reliable state-of-the-art genomic technologies for the rapid identification of genetic markers for heritable diseases in horses, which will facilitate effective genomics based selection against disease susceptibility. The diseases of particular focus for this project are osteochondrosis  (OC), insect bite hypersensitivity (IBH) and chronic progressive lymphedema (CPL). The occurrence of these diseases is a significant problem for horse owners and breeders and leads to poor animal welfare and severe economic losses. The initiative of this project is mainly based on the strong wish from the studbooks to obtain a genetic alternative to the more traditional breeding methods which are often not feasible in the smaller breeds. For each disease, a genetic component to disease susceptibility has been confirmed and several research groups in Europe have independently carried out small to medium-sized studies in order to find the causative genetic mechanisms underlying the disorder. However, the mode of inheritance for these diseases appears to be complex, and no genes or mutations have been identified yet, suggesting that analysis of much larger sample sizes is required or across datasets. This project aims to bring together the efforts of European research groups that are currently working on the genetics of disease susceptibility in horses. This collaboration will enable the groups to pool data for meta-analysis leading to more rapid progress in the identification of the genes and suitable gene markers for use in genomic selection against disease susceptibility. The SME associations, in close collaboration with the RTD performers, will develop breeding strategies that are optimized to the specific situation of that SME association. Once genetic markers are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The neuroscience of human tickle perception' (TICKLISHUMAN).

assistant: **Concept**

Tickle is one of the most enigmatic human sensations: we do not know how a touch can turn into tickle, and why our brain responds to other peoples tickles but not to our own. To date, there is no theory that can satisfactorily explain why touch on certain body areas feels more ticklish than on others, and why some people are more prone to be tickled compared to others. Despite this fundamental knowledge gap, experiments on tickle perception have been extremely scarce, and there is currently no active research on the topic at an international level.In TICKLISHUMAN, I propose a new interdisciplinary approach to understand the neuroscience of human tickle perception, based on modern haptic technology, somatosensory psychophysics, multivariate pattern analyses of neuroimaging data, brain stimulation, and advanced statistical modelling techniques. First, my team and I will establish a stimulation protocol that optimally induces tickle sensations, and we will identify their neural profile. Building upon my findings on how the brain differentiates between self-generated and externally generated touch, we will delineate the body maps where the perception of tickle is amplified and we will determine the brain mechanism that cancels self-generated tickle sensations. Finally, we will model individual differences in tickle perception as a function of central, peripheral, personality, and demographic characteristics. TICKLISHUMAN has the strong potential to radically transform our scientific and popular thinking about the social, motor, and clinical neuroscience of tickle. The novel insights from the project will permit to explore the very undervalued clinical and functional implications of tickle in the next decades, including its use as a cognitive biomarker in schizophrenia and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Noble metal nano-structures - Preparation using soft templates, characterisation and applications'.

assistant: **Objectives**

The present project is aimed at imparting thorough training to the candidate in nanomaterials synthesis, characterisation and applications. We have recently adopted an innovative approach for the synthesis of noble metal nanostructures having high catalytic activity for selective hydrogenation reactions using swollen mesophases of anionic surfactants as soft templates. Two patents have been obtained for the works related to this.   In the present project bi-metallic nano structures of Pt and Pd alloyed with transition metals and other noble metals will be prepared using cationic, anionic and non-ionic surfactants forming mesophases of different structures (hexagonal, lamellar or cubic). Radiolytic (gamma and electron beam) and chemical reduction methods will be used to reduce the metal ions in the mesophase. The mechanism of fast reduction reactions will be studied using unique ultra fast lasers at the state of the art facilities available in LCP called ELYSE. The novel nanostructures thus produced such as clusters, rods, wires etc. would be thoroughly characterised using most modern techniques such as TEM, HRTEM, STM, AFM, XPS etc. Their potential application as catalysts for selective hydrogenation, electro-catalysts for fuel cell reactions and hydrogen storage would be investigated in collaboration with academic and industrial partners. The electronic, optical and magnetic properties would be investigated during the re-integration phase in India.   Therefore, the project is expected to increase our knowledge of the formation of metallic nanostructures using soft templates, their morphology-activity relationship and novel catalysts for many industrial processes and fuel cell applications. The proposed project will not only empower the fellow to establish an independen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'DNA damage response: ATMIN regulated non-canonical ATM activation'.

assistant: **Innovation**

The checkpoint kinase ATM (Ataxia Telangiectasia Mutated) transduces genomic stress signals to halt cell cycle progression and promote DNA repair in response to DNA damage. ATMIN (for ATM INteractor) is a cofactor for ATM that shares functional homologies with another cofactor, NBS1. Whereas NBS1 is required for ATM function after induction of double-stand breaks (DSBs), ATMIN is essential for ATM signaling triggered by agents that induce ‘chromatin changes’ (including chloroquine and osmotic stress). However, the significance of this non-canonical mode of ATM signaling has been unclear.My recent work has shown that the ATMIN/ATM signaling pathway is crucial for the function of the ATM kinase, and hence the maintenance of genomic integrity and tumour suppression. In order to determine whether ATMIN is required for any of the physiological functions of ATM, we generated a conditional knock-out mouse model for ATMIN in B cells. ATM signaling was dramatically reduced following osmotic stress in ATMIN-mutant B cells. As a consequence, ATMIN deficiency led to impaired class switch recombination, and subsequently ATMIN-mutant mice developed B cell lymphomas. Thus, somewhat surprisingly given the large body of evidence supporting a role for NBS1 in ATM activation, ablation of ATMIN-dependent ATM activation leads to a severe defect in ATM function. Thus this data strongly argues for the existence of a second independent mode of ATM activation that contributes to ATM function. The molecular trigger (which can be mimicked by osmotic stress) and the components of this second ATMIN-dependent arm of the ATM pathway are unknown, but my data clearly show that it is physiologically relevant.It is worth noting that while a large amount of scientific effort has gone into characterising A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Intensified Heat Transfer Technologies for Enhanced Heat Recovery' to be submitted under Seventh Framework.

assistant: **Abstract**

A core part of this proposal is the development of methodologies to select and rigorously design the appropriate type of enhancement technology into energy optimisation studies to a practical level, whereby process plant engineers can plan and carry out plant energy reduction programmes in which they will have confidence. The project aims to achieve at least 20% to 30 % energy savings in the energy recovery systems from the successful completion of the project, through: (i) Enhancing our understanding of heat exchange and waste heat recovery; (ii) Combining enhanced heat transfer innovative design to achieve the synergy of separate novel technologies with focus on conventional, plate-fin and membrane exchangers. Current trends will be taken into account that whilst new types of exchangers are making an increasing impact and acceptance in the process industry, the main exchanger types are based around tubular constructions, shell and tubes and air cooled exchangers and that it is likely to remain so for many practical and pressure withstanding reasons. (iii) Proposing new materials of improved economic and environmental performance as heat transfer media (with focus on advanced heat transfer fluids). (iv) Implementing the developed technologies effectively in heat exchanger networks (HENs) through intelligent process integration and control techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Flexible FE/BE Sensor Pilot Line for the Internet of Everything' (IoSense), addressing dissemination and exploitation.

assistant: **Impact**

The EU has set the stage to empower semiconductor manufacturing in Europe being one of the key drivers for innovation and employment and creator for answers to the challenges of the modern society. Aim of IoSense is to boost the European competitiveness of ECS industries by increasing the pilot production capacity and improving Time-to-Market for innovative microelectronics, accomplished by establishing three fully connected semiconductor pilot lines in Europe: two 200mm frontend (Dresden and Regensburg) and one backend (Regensburg) lines networking with existing highly specialized manufacturing lines. Focus is the availability of top innovative, competitive sensors and sensor systems “Made in Europe” for applications in Smart Mobility, Society, Energy, Health and Production. Today competitors are already involved in the development of sensor systems for applications in the emerging “Internet of Things”. But there is a significant gap between those forces and the capabilities to bring ideas into the high volume market fast enough. IoSense will close this gap by providing three modular flexible pilot lines being seamless integrated in the IoT value crating networks and ready to manufacture each kind of sensor system prototypes. IoSense will increase the manufacturing capacity of sensor/MEMS components in the involved pilot lines by factor of 10 while reducing manufacturing cost and time by 30%. IoSense is designed to enable focused development work on technological and application oriented tasks combining with market orientation. “Design to Market Needs” will be accomplished by customer involvement, embedding all required functionality besides sensors. Finally, the time for idea-to-market for new sensor systems is intended to be brought down to less than one year. As a r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GTPase regulated signalling pathways: role in the transition from mesenchymal to amoeboid tumor cell invasion', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Malignant tumours have acquired the ability to invade surrounding tissue. One component of the invasive phenotype is increased cell motility. Two modes of tumour cell motility have been described: (i) an elongated/mesenchymal mode that requires extra-cellular proteolysis and (ii) a protease independent/amoeboid/rounded mode. Importantly, these two modes of migration are inter-convertible revealing a novel cellular and molecular adaptation pathway in the switch from a path generating to a path-finding migration mode.The aim of this proposal is to investigate the molecular mechanisms underlying this switching process. Several different conditions will lead to switching. Tumour cells that migrate in a 3D matrix with an elongated phenotype switch to rounded/amoe boid mode in the presence of protease inhibitors. Conversely, it has been demonstrated that cells, which move in the rounded/amoeboid fashion will convert to elongated movement in the presence of myofibroblasts. Furthermore, cells can be made to switch between rounded and elongated morphology by plating matrices of different rigidity. Rigid non-deformable matrices favour the elongated morphology while deformable matrices favour a rounded morphology.The aim of this project is to identify (i)changes in gene expression leading to changes in cell morphology and mode of cell movement and to identify (ii)signalling pathways driving the changed morphology. These are important questions since the ability to switch modes of movement has important implications for the rapies to stop tumour cell invasion and thus metastasis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Stability of supersonic boundary layers' (1994-1998).

assistant: **Innovation**

Research objectives and content The topic of the project I am going to carry out under the supervision of Dr. N. Peake is the study of the 'absolute instability' on swept wings in a compressible supersonic flow, enabling the understanding of a new potential mechanism for transition to turbulence in boundary layers . I also propose to work on the associated 'receptivity' issue of how disturbances get into boundary layer using asymptotic 'triple deck' analysis in the limit of large Reynolds numbers. In particular I will look at the 'distributed receptivity' for a supersonic boundary layer in which the surface roughness is supposed spatially periodic. Although the research proposed here is mainly theoretical it is to be emphasised that the project will also involve some experimental work . Training content (objective, benefit and expected impact) The main aim of the research is the development of a new efficient mechanism of transition to turbulence in supersonic boundary layers in order to get an accurate prediction and a considerable reduction of the drag for a new generation of subsonic and supersonic aircraft . Links with industry / industrial relevance (22) During the 3 years of Ph.D. study it will be possible to collaborate closely with engineers at the British Aerospace Airbus Ltd. in Bristol with whom N. Peake has a strong close collaboration. This research could make a significant contribution to Europe efforts in the development of a second generation of civil transport aircraft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REINFORCEMENT THE CAPACITIES OF THE DEPARTMENT OF POLYMER ENGINEERING FOR CHARACTERIZATION AND TESTING OF POLYMERS' (RECAPO) targeting Sixth Framework.

assistant: **Abstract**

The main goal in the proposed project is reinforcement of the research capacities of the Department of Polymer Engineering (DPE) at the Faculty of Technology and Metallurgy Skopje and to promote this Department as certified reference institution. This institution will provide in the region comprehensive, interdisciplinary services in the development, processing, characterization and testing of polymer based and recycled materials. A permanent work on establishing and strengthening the network of research and industrial experience within the WBC (Western Balcan Countries) is also foreseen.Actually many products from Macedonian and Kosovo polymer industry cannot be exported in other countries because they are not proper certified. For this reason the policy of Macedonian Government is to establish the reference polymer laboratory that will be able to coverall necessary tests for polymer raw materials and final products. The existing policy of DPE is faster development of educational and research activities and to follow the modern trends in new polymer materials and recycling of plastic.For realization of this policy, it is necessary to provide some pre-condition, mainly connected with improving the knowledge, research, methodologies, financial support, human resources etc. The most common way for providing these pre-conditions is establishing the link and collaboration with similar, more developed institutions in EU countries, and to benefit from their knowledge and experience. In this manner the activities and scientific level in DPE will be enhanced, so it could be the main promoter for plastic industry development in Republic of Macedonia, as one of the actual most promising activity for opening new jobs in small end medium size enterprises.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'ESSENCE: Empathic platform to personally monitor, Stimulate, enrich, and aSsist Elders aNd Children in their Environment'.

assistant: **Concept**

ESSENCE aims at transforming the lessons learnt from the COVID-19 in a huge opportunity that exploits technology toward a deep evolution of the services targeting vulnerable populations: non- or pre-frail seniors, and children of the first years of primary school. To contribute to the public health response in the context of the ongoing epidemic, and preparedness for future emergencies, ESSENCE aims at boosting the creation of a new model of home-based care that relies on stimulation, remote monitoring, tele-assistance, and connection between users, families, and professionals.ESSENCE builds upon the results of MoveCare H2020 and adopts an iterative optimization process between two pillars - technology transfer of a subset of successful modules and feedback received from testing on target users – with the final target of achieving CE mark and promptly entering the markThe ESSENCE system consists of three main components:- the Community-Based Activity Center (CBAC), a holistic platform, based on virtual rooms, providing a series of diverse activities with declared recreational, socialization, educational, and assistive purposes;- the Monitoring Module, that gathers heterogeneous information from the activities mediated by the CBAC, a smart ink pen, and diverse applications to extract cognitive, physical, and emotion-related indicators. AI is exploited to provide personalized feedback, and alerts for deviations from physiological behaviors;- the ESSENCE Manager, that acts as the system control unit to manage user profiling, system configuration, possible system malfunctioning, and delivery of notifications, alerts, or feedback.Through ESSENCE, a multi-level user empowerment will be promoted both by: (i) delivering empathic feedback aimed at maximizing engagement and relie