RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pharmacokinetic studies of encapsulated Cpl-1 on the mucosal surface, from mouse to human' (PNEUMOLYSINS) under Sixth Framework.

assistant: **Objectives**

This project has been designed in order to contribute to the development of a novel technology consisting to use bacteriophage lytic enzymes as agents for controlling bacterial populations on human mucosal membranes. These tissues are the reservoir for man y pathogenic bacteria found in the environment (i.e., pneumococci, staphylococci, streptococci). In most instances, it is this mucosal reservoir that is the focus of infection in the population. By reducing or eliminating this reservoir of pathogens in the community and controlled environments (i.e., hospitals and nursing homes), the incidence of disease will be markedly reduced. Because of the fear of developing resistances, antibiotics are not indicated. Thus, lytic enzymes may provide a good alternative. Cpl-1, a pneumococcal phage lysozyme has been chosen as a model. S. pneumoniae is a leading cause of acute otitis media, meningitis, pneumoniae, and sepsis. It is becoming increasingly resistant to multiple classes of antimicrobial agents. Because the hal f-life of Cpl-1 in the blood of mice is relatively short and is thought to be insufficient to obtain complete eradication of pneumococci, we propose to encapsulate it into liposomes. During the outgoing period, the antimicrobial activity and the residence time on mucosal membrane of different liposomal preparations will be tested in mice. The acquired knowledge will then be applied, in the laboratory of the return host, in order to develop a phase I human clinical trial with the more effective combination. This project will be a great asset to the scientific career of the candidate, providing him all the necessary tools to develop his own infectious disease program. Moreover, the project will significantly increase the scientific expertise and attractiveness of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building a global multidisciplinary digital governance and policy modelling research and practice community' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

eGovPoliNet sets up an international community in ICT solutions for governance and policy modelling. The international community of researchers and practitioners will share and advance research and insights from practical cases around the world. To achieve this, eGovPoliNet will build on experiences accumulated by leading actors bringing together the innovative knowledge of the field. Capabilities, tools and methods brought forward by academia, ICT industry, highly specialised policy consulting firms, and policy operators and governance experts from governments will be investigated and collected in an international knowledge base. Comparative analyses and descriptions of cases, tools and scientific approaches will complement this knowledge base. Therewith, the currently existing fragmentation across disciplines will be overcome.Functions of eGovPoliNet towards community building, RTD monitoring and comparative analysis will mainly be conducted in an internet-based participatory manner, complemented with regular physical meetings attached to conferences. Community building of experts from academia, industry and public organizations, and other interested stakeholders will be supported by a community portal for knowledge sharing, collaboration, dissemination, and multidisciplinary constituency building in an open environment. eGovPoliNet expertise covers a wide range of aspects for social and professional networking and multidisciplinary constituency building along the axes of technology, participative processes, governance, policy modelling, social simulation and visualisation. Regular physical and virtual meetings with off- and online discussions and comparative studies will contribute to capacity building of the community.Through sharing of approaches and exposing them
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implementation and preclinical testing of a closed-loop control system for deep brain stimulation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Over the past 25 years deep brain stimulation (DBS) has emerged as an effective treatment for the symptoms of Parkinson's disease (PD). Despite its success, the mechanisms of DBS are not yet fully understood. Moreover, patients experience side effects and poor control of symptoms associated with suboptimal programming of stimulus parameters.  Current DBS systems operate in an 'open-loop' configuration with stimulus parameters (pulse amplitude, duration and frequency) empirically set and remaining fixed over time. Closed-loop DBS offers an alternative approach that has the potential to overcome current limitations and increase therapeutic efficacy, while reducing side-effects and increasing battery life, by automatically adjusting stimulation parameters as required. Although the potential benefits of closed-loop DBS are widely recognised, these systems have not yet been implemented clinically. Under the parent ERC project DBSmodel, we have developed biophysically detailed computational models of the neural circuits in the brain during DBS and are using these to develop and test novel algorithms for closed-loop DBS.  Before these can be trialled in humans, however, feasibility must first to be demonstrated through implementation on a prototype device and pre-clinical testing in animal models. ERC proof of concept funding will enable us to do this by implementing and testing a novel closed-loop DBS system in an animal model of PD. The experimental validation will confirm the efficacy of a prototype solution suitable for translation to human studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Euroconferences on Immunobiology of Transplantation: from basic science to clinical applications', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The transplantation of cells, tissues & organs is a rapidly evolving field of scientific knowledge & medical practice worldwide. Clinical applications include haemopoietic malignancies, immuno-deficiencies & organ failure. Transplantation also holds strong therapeutic potential for many other chronic degenerative diseases. The extreme genetic diversity of the European populations (donors/recipients), the specificities of Europe's national Public Health systems, & the fact that the legal, ethical & societal issues posed by basic & clinical research/practice in this field vary throughout Europe, all confer unique characteristics to the practice of transplantation biology/medicine in Europe. Transplantation biology/medicine is a complex, integrated field, which requires a multidisciplinary approach to the genetics, & the molecular/cellular immune mechanisms controling graft acceptance & optimal longterm function.A full understanding of the immunogenetics & histocompatibility governing alloreactivity is a prerequisite for optimal matching of donors & recipients. Haemopoietic & organ transplantation, as well as the fields of cancer, auto-immune & inflammatory diseases, & allergy will benefit from innovative immuno-intervention (tolerance induction, immune deviation & suppression, specific vaccination & immuno-modulation) solidly founded on basic concepts & experimental research. Despite excellent European basic research & transplant centres, to date no European forum for high-level training exists in this field. This proposal concerns the creation of a multidisciplinary forum for basic & clinical scientists working in the academic & industrial settings, at the junior & senior levels. It also intends to promote reflection, at the European level, on the ethical, legal, societa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Earthquake-resilient self-centering steel frame'.

assistant: **Innovation**

An important requirement of performance-based earthquake engineering is the simultaneous control of structural and non-structural damage. Structural damage measures are related to story drifts, inelastic deformations and residual drifts. Non-structural damage measures are related to story drifts and storey accelerations. Earthquake reconnaissance reports highlight that injuries, fatalities and economical losses related to failure of non-structural components far exceed those related to structural failures. Moreover, explicit consideration of non-structural damage becomes vital in the design of critical facilities such as hospitals carrying acceleration-sensitive medical equipment, which have to remain functional in the aftermath of an earthquake. Structural and non-structural damage results in direct and indirect losses such as repair costs and costly downtime during which the building is repaired and cannot be used or occupied. Therefore, there is an urgent need for minimal-damage structures that can truly achieve seismic resilience.  Researchers have developed self-centering frames with the goal of avoiding residual drifts. Other studies focused on increasing the energy dissipation capacity of structures by adding dampers with the goal of reducing storey drifts and storey accelerations. This project aims to couple, for the first time, self-centring systems and modern seismic energy dissipation systems with the goal of developing a novel earthquake-resilient steel frame. The optimal combined design of the self-centering and energy dissipation mechanisms will lead to a steel frame with superior minimal-damage seismic performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HYDROELECTRIC POWER PLANT WITH INTAKE STRUCTURE,STORAGE RESERVOIR AND PENSTOCK ON THE RIO CAVO AT PENNABILLI' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The aim of the project is to install a new hydroelectric plant of the capacity of 540 kWe on the Rio Cavo at Pennabilli in central Italy. The plant is composed by diversion weir, storage reservoir, penstock and a Pelton turbine, manufactured by the first proposer. The electricity produced will be sold totally to the national grid.1. INNOVATIVE TECHNOLOGY :The innovative apsect of the project is that the turbine is self-produced by the project proposer, thereby creating the producer/investor innovative figure and a low cost, reliable project typology. The works will be executed in local materials and the constructions will be well integrated in the natural landscape, thus creating a minimum impact on the environment and raising public acceptability.2. CONTEXT :The plant will be located in Pennabilli in a mountainous area where the depopulation index is high. Thence the desire to create an innovative investment, bringing income in the area, in respect of the natural environment and creating new business opportunity for the production and diffusion of new small hydro plants in similar mountainous areas. The plant will benefit from the incentivating price of selling electricity to ENEL according to Law 9/90 and 10/90. Another important aspect is that in summer during the periods of non-production of electricity the basin will be used for leisure activities (fishing competitions, visits, etc.) and at the same time during the year the penstock pressure will be utilised to irrigate a poplar plantation.3. ECONOMIC ASPECTS :The double-rotor, Pelton turbine, related to the fall and to a maximum discharge will develop a power of 540 kW. Such a power is necessary because the Rio Cavo, as a typical mountain river, alternate periods of high flow with periods of low flow. The hydro-pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lean data management for maintenance value' (LeaD4Value) targeting Horizon 2020.

assistant: **Abstract**

The possibilities of data-based maintenance management as well as interconnected, smart, and autonomous assets have been discussed lately but in practice there are still a number of major problems regarding e.g. the amount, quality, integration, and exploitation of maintenance data. In LeaD4Value these problems are addressed through lean maintenance data management to realise increased business value. Contrary to the Big Data hype, the idea here is to focus on the data decision support tools to be constructed based on analytical modelling and statistical analyses. Data will be collected from computerized maintenance management systems and enterprise resource planning systems of the two seconded companies, as well as from some of their employees via surveys and interviews. The results include e.g. a map of data exploitation paths, a process model, and a performance measurement system for lean maintenance data management. These tools can be used to reveal unnecessary maintenance tasks and data collection, missing data collection, or potential to increase the business value of maintenance. The role of world-class maintenance is highlighted in European manufacturing, because a majority of new production-related investments are directed to other continents. The proposed work is multidisciplinary by nature, combining aspects of business value management, reliability and maintenance engineering, and data sciences. The multidisciplinary view is needed, for asset management is challenged by maintenance engineers and managers understanding the technical aspects of maintenance but being unable to communicate these to the company decision makers in terms of business value. Too often this leads to short-sighted decisions. The project will expand the competences of the fellow in mult
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Designation and Management of Marine Reserve Networks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This research will explore physical elements of the environment and their spatial character, principles of conservation science, human needs and institutional constraints for the purpose of establishing marine protected areas.  The goal is to identify institutional and societal constructs that are frequently left out of decision-making for marine protected area design and management.  Research conclusions will be based on comparison of spatial outcomes.  The researcher will synthesize approaches that have addressed the challenges of working in a multi-faceted, high-use marine environment in which there are varying levels of information, challenges of cooperation between local and regional managers, scientists and users and difficulty soliciting the input of relevant stakeholders.  Major phases of the research are: 1) development of a typology of the designation of terrestrial reserves in Israel and marine reserves in the territorial waters of countries along the Mediterranean Sea; 2) review and application of appropriate decision support tools that can address at least two identified challenges in the Israeli context: connectivity of reserves and stakeholder participation; and 3) comparison of outcomes from the use of decision support tools chosen based on the country context needs and actual reserve design and management plans proposed by the nature protection authorities in Israel.  This research can inform regulators, policymakers and conservationists about what various theoretical views and values mean when applied to conditions in the field (both in terms of physical resources and institutional constructs) and how and to what extent real-world outcomes engender preferred practices based on ecosystem based management and integrated coastal zone management for marine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Environmental innovations and SMEs - The dynamics of environmental innovations.'.

assistant: **Innovation**

To identify and analyze the driving forces, strategies, the role of institutional regimes and of the key actors in the creation and diffusion of different types of environmental innovations in SMEs. To formulate a general policy framework for stimulation of environmental innovations in SMEs, as part of an ecological modernisation strategy.OBJECTIVES: To identify and analyze the driving forces, strategies, the role of institutional regimes and of the key actors in the creation and diffusion of different types of environmental innovations in SMEs. To formulate a general policy framework for stimulation of environmental innovations in SMEs, as part of an ecological modernisation strategy. DESCRIPTION: The research focuses on the role of selected innovative small and mediumsized enterprises (SMEs) in the creation and the adoption of environmental innovations, which may be 'end-of-pipe as well as 'process integrated . The project examines the creation and diffusion of environmental innovations within five very different national systems of innovation in Europe (The Netherlands, Denmark, United Kingdom, Italy and Portugal) and different clusters of manufacturing industry (e.g. paint industry, textile and apparel industry, printing industry, mechanical engineering, foundries, food processing). In these clusters, environmental innovations are required in order to reduce emissions and SMEs play a crucial part in the creation and diffusion of such innovations. The project consists of three stages: i) for each industrial sector and for each country selected the major characteristics, the technological trajectories and the national institutional framework, including actors, and policies, are examined; ii) in each country four case studies are carried out to identify the key actors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Personalised Health Monitoring and Decision Support Based on Artificial Intelligence and Holistic Health Records'.

assistant: **Innovation**

The specific focus of iHELP is on early identification and mitigation of the risks associated with Pancreatic Cancer based on the application of advance AI-based learning and decision support techniques on the historic (primary) data of Cancer patients gathered from established data banks and cohorts. This analysis helps to (i) determine key risks associated with Pancreatic Cancer, (ii) develop predictive models for identified risks, and (iii) develop adaptive models for targeted prevention and intervention measures. Based on these developments, the project selects high-risk individuals that are invited to take part in the pilot activities or digital trials. The digital trials are carried out through user-centric mobile and wearable applications that apply proven usability principles to offer more awareness, more engaging experience for health monitoring, risk assessment and personalised decision support. Close collaboration between clinical and AI experts focus on drawing decision support against identified/predicted risks and providing personalised recommendations (e.g. lifestyle changes, behavioural nudges, screening test etc) to the participants in the digital trials. The iHELP (mobile and wearable) technology solutions help in validating iHELP solutions and raising health related awareness at individual level. The (secondary) data gathered through the mobile and wearable applications (concerning life style, behavioural, social interactions and response to targeted prevention and intervention measures) is integrated with primary data in the standardised HHR format – within a big data platform.  Frugal AI-based learning techniques are developed to provide near real-time risk assessment based on the integrated and standardised HHR data. iHELP solutions are targeted at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Brazilian-European partnership in Dynamical Systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This is a project for a partnership between leading Brazilian and European research groups in dynamical systems, a prominent subject in mathematics. An extensive consortium of European and Brazilian institutions will collaborate to provide world leading critical mass and support for research on the very forefront of the field. Work Packages reflect parallel priorities in the research.  Transfer of knowledge is facilitated by two large conferences and five smaller workshops. The project has excellent strategic value in view of the development of closer ties in higher education and research between the European Research Area and Brazil.