RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Organoids as infection model', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The mucosal surfaces of the human stomach and gut are in constant contact with bacteria and viruses. This encompasses the often mutually beneficial relationships with commensals as well as encounters with pathogens. The study of host-microbe interactions is hampered by a lack of suitable model systems: many bacteria or viruses cannot be cultured or existing models do not sufficiently recount the human disease. This project aims at the development of new in vitro models and the subsequent characterization of the host response to three microorganisms: the carcinogenic bacterium Helicobacter pylori, the most common cause for non-bacterial gastroenteritis, Norovirus, and the commensal Small Filamentous Bacteria. A culture system that was recently developed in lab of Dr. Clevers will be used in which adult stem cells give rise to three-dimensional structures (‘organoids’) resembling mature, polarized epithelium of the stomach, small intestine and colon.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Real time measurement of wear and damage in tyres to reduce accidents and enable the ""tyre as a service"" model""' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Several studies highlight how tyres failure or excessive wear is a critical aspect in accidents and avoiding vehicles circulating with inadequate tyres could reduce the probability of accidents of 28.5%, (56% on snow and up to 84% on wet roads). Tyre Pressure Monitoring Systems (TPMS) mandatory in new cars since 2014 only measure pressure and temperature of tyres, while the tyre industry is looking for real time monitoring of wearing status to be integrated in new intelligent tyres, enabling innovative “tyre as a service” business model or preventive maintenance. Wriggle has developed a solution capable of:  i) measuring in real time the tread depth of tyres and monitor the extent of wear; ii) identifying possible damages and deformations of tyres that precede sudden failures or explosions, exploiting the physical principle of variation of electrical conductivity related to the tread thickness, without integrating any digital device in the polymeric mixture of the tyre, as currently targeted by competing solutions under development. The system can be easily installed into new vehicles by OEM or integrated into any type of existing vehicles using an ad-hoc or existing BlackBox system for after-market. Wriggle aims at licensing the commercialization of SMART-Tyre to a tyre manufacturer and licensing production of receiver to TPMS manufacturer. Considering a penetration in 5 years of 6% of available market of new light vehicles and 12% of heavy vehicles in EU and US only, Wriggle would reach in 2025 revenues of 13.6 M€ and EBIT of 8.7 M€. Wriggle targets to carry out product-fit, validate technical and cost/price assumptions, validate business model and reach MoU with one tyre manufacturer and one TPMS manufacturer for future co-development and validation to be carried out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '"The Commentary on Auspicious things"". A Pali text from Northern Thailand""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of this project is to study a major work of Buddhist literature in Southeast Asia, the Mangalatthadīpanī (“Discourse on Auspicious Things”). This text is of considerable length and reaches about 30 folios in manuscript form and about 1000 pages in printed editions in vernacular scripts. Written in Pali (the canonical language of Theravada Buddhism) in Chiang Mai (present day Northern Thailand) at the beginning of 16th century, this text was spread, glossed and translated across a large part of the Indochinese peninsula, including Thailand, Cambodia, Laos and Burma, becoming one of the most famous and most influential texts throughout the whole region. Indeed many monks of the Thai-Lao and Khmer cultural worlds consider the Mangalatthadīpanī to contain the crucial and essential points for their knowledge of the Pali tradition. As it quotes extensively from canonical and postcanonical texts, it is valuable for indicating which texts were known in the region four centuries ago. Many vernacular texts – sermons, preaching and recitation texts – are extracted from this book. The Mangalatthadīpanī is regarded as so important that it has been used in the official Pali curriculum in Thailand since 1927 despite its northern origin.If there is a strong tradition of philology in the study of Indian, Chinese and Tibetan literature, religious texts from Southeast Asia have drawn little attention from specialists. Despite some notable exceptions, the rich literary tradition of Indochina remains largely unknown until today. For many scholars – this is particularly true in recent decades – texts are taken as an ancillary rather than as things which have a value in themselves. While this perspective may be valuable, our knowledge of the spirituality and psychology of peninsular S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Isotopes in subduction zones the metamorphic perspective' in the context of a Sixth Framework call.

assistant: **Objectives**

Much of the dynamic activity of the Earth and aposis surface is concentrated at convergent boundaries of tectonic plates, i.e., where oceanic plates are thrust under various types of overriding tectonic plates. Most material in the down-going plate in the subduction process is recycled into the Earth and aposis interior. This recycled material releases fluids from the down-going plate into the mantle, which triggers mantle melting. These melts are responsible for most of the hazardous volcanic activity on Earth, and the processes that govern melt generation have been the subject of vigourous scientific research. Numerous geochemical studies of subduction related volcanic rocks have established particular element and isotopic ratios as tools to fingerprint processes operating within subduction zones.However, current models of subduction zone processes are largely based on empirical assumptions on the composition and nature of the fluids derived from the subducted material. What is required is ground truthing of the geochemistry of fluids from recycled crust by in situ analyses on high-pressure metamorphic rocks and minerals in combination with targeted experimental studies. This project therefore focuses on the evolution of lithium and other commonly-used geo chemical trace elements and their isotopes in subduction zones.The plan is to analyse high-pressure metamorphic rocks that have been through part of the subduction process and to study experimentally diffusion of the two isotopes of Li, which are extensively used to infer crystal recycling. These data will be integrated into new models of trace-element concentrations and isotope ratios in rocks and fluids during subduction. The goal is to characterise the redistribution of trace elements and isotopes in high-pressur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Alternative healers and magistres of the North - the complex web of alternative healing in contemporary Greece'.

assistant: **Concept**

Research objectives and content Healing and magic are incorporated in Greek culture and most Greeks at some point in their life will consult a healer or magistra. The influence of magic and healing on Greek life brings a different previously unexplored aspect of Greek culture. This research will illuminate transformations and changes in the Greek culture as well as provide an examination of this amazingly complex web of healing and magic in relation to the minority groups in Northern Greece The project will address how these healers effect the Greek health system and the relation between alternative healing and Greek lifestyle. Training content (objective, benefit and expected impact) The understanding of alternative medical practices and beliefs is increasingly important in the European context where costly biomedical care is often ineffective. This is so because complementary practices often rest on traditional, non-scientific systems of belief that cause non-compliance, partial compliance or lack of timely resort to biomedicine. State medical administrators need to understand these indigenous, peripheral networks of healers and beliefs about healing in order to treat populations effectively and economically. The dilemmas that arise in this Greek case are entirely comparable to situations in other EU countries where there have been perennial skirmishes between complementary medical practitioners and the scientific medical doctors. This research promises to shed new light on this important problem. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular Details of Membrane Protein Receptor Dynamics' (GPCR-MS).

assistant: **Concept**

G-protein coupled receptors (GPCRs) are the largest family of membrane proteins. They are involved in transducing stimuli and are implicated in many diseases including cancer and Alzheimer’s disease. As a result, they are the target of ~40% of drugs on the market. Despite an extensive library of known binding partners, dynamics related to GPCR activation (and inactivation) are not fully understood. The proposal uses a hypothesis driven approach to address three interrelated objectives. Objective 1 aims to reveal the propensities for lipids to modulate ligand binding to GPCRs. Objective 2 seeks to understand the intra-molecular factors regulating GPCR and G-protein assembly and their connection with the lipid environment. Objective 3 targets GPCR assembly and binding in the context of a native membrane. This project will use fuse knowledge and tools from molecular biology (e.g. protein expression and mutation) and analytical chemistry (mass spectrometry (MS)) to facilitate a comprehensive understanding of the molecular environment governing GPCR dynamics and assembly. The results of this project will contribute to our understanding of the influence of lipids on conformational dynamics to inform efforts to better understand off-target drug effects and drug tolerance. This information could in turn reveal novel GPCR conformations that facilitate state-selective structure-based drug discovery, with great implications for human health and quality of life.This proposal aligns with goals of the Marie Skłowdowska-Curie Fellowship: I will diversify my professional profile, which has focused on fundamental MS in the US, by gaining new competences in molecular and structural biology in Europe and thereby expand my personal and professional network through international mobility. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Man and Environments in Morocco during Quaternary', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Morocco is a valuable area to study hominids and their reaction to ever-changing conditions. The MEMOQUAT project addresses chronology, evolution and adaptation, and social behaviour of humans who faced many stresses linked to geography, climate and environment. These kind of studies, at a large scale (the last Million years), have never been conducted in partnership with European universities. For the first time, a scientific project will cross each step since the discovery of archaeological artefacts until the publication of the results, with in the middle step, the setting of a dating laboratory. The MEMOQUAT project is lead by the Muséum National d’Histoire Naturelle – MNHN (France) in association with an European partner: the Università degli studi di Ferrara – UNIFE (Italy), and a third country partner: the University Moulay Ismail, Meknes – UMI (Morocco). These three partners have internationally acknowledged competences and expertise in the fields of Geochronology, Palaeontology and Prehistory, and previous experience of scientific cooperation tradition in the field of Prehistory and Geology of the Quaternary Period. The scientific collaboration intends to structure different programs already initiated between partners and support a long-term way relations between the partners. The research training and the transfer of knowledge for the study and materials dating from the prehistoric archaeology and the development of heritage valorisation are at the heart of the MEMOQUAT project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New coating materials for high performance cutting tools' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

At present high speed cutting technology is the most promising approach to increase both efficiency and precision of metal cutting processes. However there are new alloys especially difficult for machining, for instance, hardened steels used for moulds, Cr-Co alloys used for prosthesis, Ti-based, and Ni-based alloys used in gas turbines and in the aerospace industry, where high speed cutting technologies are meeting serious difficulties to be introduced. On the other hand, there are important environmental and health reasons to reduce consumption of cutting fluids used as lubricant and refrigerant agents during the cutting process. The aim of the project is to develop a new generation of complex-shape tools, made of WC-Co hard metal and coated with layers based on the B-C-N system, able to be used for high speed machining of these materials in different operations (milling, broaching, reaming, etc.).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Open Sea Operating Experience to Reduce Wave Energy Cost'.

assistant: **Objectives**

Europe is endowed with abundant wave energy which could cover some 10% of its electricity needs with a clean, predictable and job-creating resource,  which EU companies are at the forefront exploiting with little dependence on foreign suppliers.There remain important technical challenges to bring down costs to within investors’ reach, as a top priority open-sea operating experience must be analysed to permit the focus of R&D efforts on identifying and solving problems uncovered in open-sea deployments. However, to this day, most wave energy R&D does not have access to open-sea operating data as they are not shared by the companies that sponsored open-sea tests. OPERA will remove this roadblock by collecting and sharing two years of open-sea operating data of a floating oscillating water column wave energy converter. In addition the project will be the first open-sea deployment for four cost-reducing innovations that will be advanced from TRL3-4 to TRL5. Together, these four innovations have a long-term cost reduction potential of over 50%. These are: a 50% more efficient turbine, latching and predictive control, a shared mooring system for wave energy similar to those that have reduced mooring costs 50% in aquaculture, and an elastomeric mooring tether that reduces peak loads at the hull-mooring connection 70% and thus addresses one of the most pressing challenges for structural survivability of wave energy devices. Documenting and sharing this open-sea experience will also induce a step-change in our knowledge of risk and uncertainties, costs and societal and environmental impacts of wave energy. The consortium brings together world leaders in wave energy research from four European countries and the IPR owner and most advanced teams to exploit each of these innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'FLEXOELECTRIC SCAFFOLDS FOR BONE TISSUE ENGINEERING' to be submitted under Horizon 2020.

assistant: **Abstract**

Bone is the most transplanted tissue with 1.3 million procedures every year in Europe. With an increasing demographic ageing across Europe, bone transplant represents a significant socio-economic burden that necessitates new bone regeneration strategies in line with one of the Horizon 2020 priority: ""Smart Growth: knowledge and innovation based economy"".  The field of bone tissue engineering has flourished over the last decades, owing to a solid knowledge on bone biology and increased progress on materials engineering. A few weeks ago, Dr Gustau Catalan at ICN2 brought to light the groundbreaking discovery that bone is flexoelectric. In order to biomimic the flexoelectric character of bone, we aim in this project to produce new synthetic bone scaffolds that exhibit flexoelectricity. Engineering scaffolds with a flexoelectric character calls for particular design requirements. Flexoelectricity is the coupling between strain gradients and polarization, whereby any dielectric can polarize in response to an inhomogeneous deformation. In order to generate the required strain gradients within the scaffold to produce a flexoelectric effect, scaffolds will be manufactured with controlled porosity gradients by 3D printing based approaches. Three polymers used in bone tissue engineering, namely PLLA, PLGA and PCL will be investigated to produce the flexoelectric scaffolds. It is envisaged that a flexoelectric-induced polarization can be attained in any of them. In view of improving the osteoconductive, osteogenic and mechanical properties of the flexoelectric scaffolds, they will further incorporate different amounts of nanohydroxyapatite (from 0 to 50 wt %). Finite element calculations will be used to refine porosity geometries (porosity gradient and pore shape). It is expecte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'New Synthetic Approaches to Prepare Functionalized GAG Oligosaccharides as Basic Tools in Glycomics'.

assistant: **Innovation**

In the post-genomic era, glycomics, the functional study of carbohydrates in living organisms, has received increasing attention for biological research and biomedical applications. The usual techniques in glycomics need the preparation and supply of pure sugar samples. For instance, carbohydrate microarrays, carrying tens or hundreds of different sugars that are bound covalently or noncovalently in small spots on solid surfaces, are becoming a standard tool for glycobiologists to screen carbohydrate-protein interactions in a high-throughput manner and determine structure-activity relationships for specific oligosaccharide sequences. However, the supply of hundreds/thousands of saccharides is required for wider applications of this novel technology. Here, it is proposed the development of novel and more efficient oligosaccharide synthetic approaches in order to speed the preparation of sugar probes and expand the utility of carbohydrate chips. We will focus on glycosaminoglycans (GAG) that are highly sulphated polysaccharides implicated in a plethora of biological processes, such as cellular growth and differentiation, pathogen infection, and tumor angiogenesis, by interaction with a wide range of proteins. Polymer-supported approaches, using polyethylene glycol (PEG)-grafted polystyrene (PS) resins, will be tested. Alternatively, tag-assisted solution-phase synthesis of oligosaccharides (using low-molecular-weight PEG chains or fluorous tags) will be also explored. The use of an acylsulfonamide linker compatible with the activation conditions of glycosyl trichloroacetimidates will be crucial to the success of the synthesis and the production of oligosaccharides containing a functionalized linker at the reducing end for conjugation purposes. The development of new prote