RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DEferiprone Evaluation in Paediatrics' (DEEP), addressing dissemination and exploitation.

assistant: **Impact**

β-thalassaemia major is one of the most severe forms of chronic congenital anaemia. The recommended treatment consists in regular blood transfusions combined with chelating therapy to remove harmful iron accumulation in the body. The use of deferoxamine, the first chelating agent only available for subcutaneous administration  is limited due to toxicity and the lack of compliance, despite its satisfactory therapeutic effects. An oral iron chelating agent, deferiprone, was authorised in Europe in August 1999 and recommended for the treatment of iron overload in patients with thalassaemia major when deferoxamine is contraindicated or inadequate. Despite a wide experience of the administration of deferiprone for thalassaemic patients, limited data are available on its use in children below 10 years and the need for additional data in this age subset was clearly indicated  in the 2009 priority list approved by the Paediatric Committee at the European Medicines Agency (PDCO). In addition, according to the recent scientific advancements and in consideration of the anticipated benefit of this chelator in controlling cardiac iron overload, studies  evaluating the effects of the deferiprone in all the paediatric ages and in all transfusion-dependent chronic congenital anaemia (including Sickle Cell Diseases)  were also considered a critical therapeutic need.The DEEP project, in line with these premises, has been funded with the specific aim to produce a new oral liquid formulation of deferiprone suitable for the paediatric use and to provide evidences for the use of this chelator as first line therapy in the whole paediatric population  (from 1 month to 18 years) affected by transfusion-dependent chronic anaemia.The condition under study  in the DEEP project is rare. This poses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Secure OPen source softwarE and hardwaRe Adaptable framework' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Security of open-source solutions in the business interconnected market (especially in IoT where a single product may include components from various Tier 1 or OEM manufacturers) is hard to assure. OEM SW/HW developers that employ open-source solutions must assume that any component provided by 3rd parties needs to be reassessed for security as there is not holistic security auditing/testing process to cover the full production line. The plethora of open-source HW/SW solutions on devices with constrained resources and no trusted environments leads to a considerably expanded threat landscape. The restricted execution environment reduces bootstrapping new devices in an IoT network and deploying/patching them securely; and the full DevSecOps of connected device open-source HW/SW must be reformulated offering security guarantees on the usage of open-source solutions. SecOPERA will provide a one stop hub for complex OSS/OSH solutions offering to designers, implementers, operators and open-source HW/SW developers the means to analyse, assess, secure/harden and share open-source solutions as these are integrated in an overall complex product within a networked connected environment. SecOPERA provides a framework supporting the open source DevSecOps lifecycle that comprises (i) a decomposition and security audit/testing engine that analyses open source solutions (OSS/OSH) (ii) an adaptation engine that debloats OSS/OSH code to remove unrelated open-source code and reduce the code attack surface; and a security enhancement process to harden the OSS/OSH solution (iii) an updating/patching mechanism so that the SecOPERA open-source flows remain secure even if their open-source code starting points are vulnerable. On top of that, SecOPERA hub provides (iv) an open-source repository
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bringing sheet music into the Digital Era via Artificial Intelligence' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Since the ancient Greeks musical text has been preserved as written or ""sheet music"". In the last 100 years preservation of audio recordings has evolved from non-digital (vinyl discs, cassettes) to digital mediums (CDs, MP3 & streaming) with new technological possibilities as consequence. Sheet music remained static: It is mostly available on paper or as paper-scan-files. Enote sets out to evolve sheet music from paper and pdf-scans to native digital content in order to be able to apply modern-day technologies such as artificial intelligence and big data for solving key issues of modern-day musicians.Enote is developing an application for tablets and smartphones which for the first time in history will give musicians access to a comprehensive library of native-digital sheet music including artificial intelligence functionalities. This allows for ground-breaking features solving core problems of static sheet music itself and the limited possibilities of interaction that come with it.""


**Keywords:** Digitization,classical music,sheet music
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting of angiogenic tgf-b signalling in cancer and cardiovascular diseases' (T-ANGIOVASC), addressing dissemination and exploitation.

assistant: **Impact**

Diseases as common as cancer, diabetes associated blindness and coronary arteriosclerosis, and as rare as hereditary hemorrhagic telangiecstasia (HHT), a chronic, bleeding ailment, would benefit from exogenous control of angiogenesis. Gene ablation in mice has shown that the transforming growth factor (TGF) beta signal transduction pathway is essential for normal vasculogenesis and angiogenesis while mutations in TGF beta-receptors cause HHT. Treatments of vascular disease based on interference with local ligand concentrations are not feasible because of side effects on the immune system and fibrosis. Here, we will use state-of-the-art technology to identify target genes downstream of activated receptors in vascular cells and develop cell culture and animal models for vascular disease associated with defective TGF beta signalling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'childrEn and Adults heaRing in noise: individual Differences in the Neurophysiology of Audition' (EAR-DNA) targeting Horizon 2020.

assistant: **Abstract**

Over 5% of the world population suffers from at least a moderate hearing loss (thresholds between 40-70 dB), which has pervasive effects on children’s academic performance or working adults’ professional life. Despite recent progress in hearing aid devices restoring speech intelligibility in quiet, understanding speech in noise remains a challenge for hearing-impaired (HI) individuals. Therefore, the present project aims to improve speech perception in noise in HI listeners by paving the way towards the development of neuro-steered hearing aids. To do so, we will use electroencephalography to investigate the neural correlates of three key factors underlying speech perception in noise: stream segregation, auditory attention and listening effort. They will be approached by means of neural entrainment, neural gain, and alpha oscillations, respectively. Although it is technically possible to simultaneously record the three measures, which would provide a comprehensive view on the neural processes underlying HI listeners’ difficulties in noise, it has not been done so far. Here, we will (i) first evaluate the effect of mild to moderate hearing impairment on stream segregation, auditory attention and listening effort in HI and normally-hearing (NH) young adults. Because hearing loss affects the development of auditory processing throughout childhood, this project will also aim to (ii) determine how neural processing of speech in noise develop in HI children. Last, based on the findings from (i) adults’ processing of speech in noise, we will explore the possibility to use neurofeedback (iii) to improve NH and HI listeners’ perception of speech in noise. The proposed project uses an innovative multidisciplinary perspective to tackle a remaining challenge in the field of auditor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ACceleraTing PHotonics innovAtion for SME’s: a one STop-shop-incubator' (2014-2020).

assistant: **Concept**

ACTPHAST 4.0 (ACceleraTing PHotonics innovAtion for SMEs: a one STop-shop-incubator) is a unique photonics innovation incubator for Europe which is perfectly aligned with the needs of SMEs in overcoming the challenges and seizing the opportunities afforded by the new digital revolution of Industry 4.0 in which photonics technologies are a key enabler. ACTPHAST 4.0 will directly support the broader and faster take-up of photonics by a critical mass of SMEs by providing action-oriented solutions on two complementary levels, driven by the business needs of the companies: (i) ready-made access to rapid prototyping services using the top photonics technologies and expert know-how of Europe’s leading photonics competence centers covering the entire integrated supply chain of photonics technology platform capabilities to make deep interventions in the SMEs’ new product development through focused short-duration co-innovation projects; combined with (ii) professional coaching on the technical, business and financial aspects of the innovation process, from concept feasibility through to a mass-manufacturable marketable product. ACTPHAST 4.0 is designed to ensure that all of Europe’s SMEs, in particular first users and early adopters across a wide range of end user industries, have open access to the incubator for timely, efficient and cost-effective photonics innovation support. As a result, ACTPHAST 4.0 expects to boost photonics innovation in Europe at a scale and with a leveraging factor never seen before, delivering a substantial increase in the revenues, venture capital and jobs across all of the supported companies. In addition, through its tight links with the EU pilot lines, as well as its collaboration with smart “first mover” regions across the EU on best practices for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular control of self-renewal and lineage specification in thymic epithelial cell progenitors in vivo.' (2014-2020).

assistant: **Innovation**

The development of vaccines for the treatment of infectious diseases, cancer and autoimmunity depends on our knowledge of T-cell differentiation. This proposal is focused on studying the thymus, the organ responsible for the generation of T cells that are responsive against pathogen-derived antigens, and yet tolerant to self. Within the thymus, thymic epithelial cells (TECs) provide key inductive microenvironments for the development and selection of T cells that arise from hematopoietic progenitors. As a result, defects in TEC differentiation cause syndromes that range from immunodeficiency to autoimmunity, which makes the study of TECs of fundamental, and clinical, importance to understand immunity and tolerance induction. TECs are divided into two functionally distinct cortical (cTECs) and medullary (mTECs) subtypes, which derive from common bipotent TEC progenitors (TEPs). Yet, the genetic and epigenetic details that control cTEC/mTEC lineage specifications from TEPs are unsettled.My objectives are to identify TEC progenitors and their niches within the thymus, define new molecular components involved in their self-renewal and lineage potential, and elucidate the epigenetic codes that regulate the genetic programs during cTEC/mTEC fate decisions. We take a global approach to examine TEC differentiation, which integrates the study of molecular processes taking place at cellular level and the analysis of in vivo mouse models. Using advanced research tools that combine reporter mice, clonogenic assays, organotypic cultures, high-throughput RNAi screen and genome-wide epigenetic and transcriptomic profiling, we will dissect the principles that underlie the self-renewal and lineage differentiation of TEC progenitors in vivo. I believe this project has the potential to co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gender, Conflict and Coercive Control:  A Feminist Phenomenological Expansion of Conflict-related Harm' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

GENCOERCTRL is the first transnational empirical theoretical qualitative study of the gendered phenomenon of conflict-related coercive control. Responding to flourishing multi-interdisciplinary interest in physical and sexual forms of conflict-related violence against women (CRVAW) over the last two decades, it reorients scholarship towards the less observationally evident harm of coercive control. Preliminary evidence shows that in conflict settings, women may experience coercive control in the context of informal armed group governance and through the coercive realities of conflict transition, with transitional justice mechanisms critical to making such harms visible for engagement. Coercive control, as an invisible but insidious harm, and coercive control as a lens through which to understand womens experiences of conflict, has received little to no scholarly examination. GENCOERCTRL gets ahead of its pending travel into interdisciplinary fields on conflict violence by establishing the basis for the theoretical and empirical expansion of a new field of study of the gendered phenomenon of coercive control. The central research question addresses the multi-dimensional nature of the coercive realities in which women experience coercive control in conflict and transition: How is coercive control in conflict-affected contexts lived and understood by women for whom it is already co-constitutive of their socially coercive realities? It is addressed across four phases: development of a new feminist phenomenological methodology for studying the lived experience of the gendered phenomenon of conflict-related coercive control; generation of unique empirical phenomenological understanding of coercive control in Colombia, Northern Ireland and Sri Lanka; analysis of transitional j
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'WALNUT: PRODUCTION OF HIGH QUALITY TIMBER IN EUROPE. UP-TO-DATE TOOLS FOR TREE ADAPTATION, WOOD STANDARDS AND MANAGEMENT' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The objectives of the W-BRAINS (Walnut - Basic Research for Agro-forestry and Industry : Network and Standards) programme are to determine criteria of walnut wood quality for commercial application including logs or end-products (furniture) and to increase the production of high-quality wood in Europe using walnut.Walnut trees (J. nigra, J. regia and their hybrids) produce high quality timber and veneer (100 M3/ha after 50 years, 600 ECU/M3). Well-accepted by farmers, they are ideally suited for use in agriculture reconversion and diversification. Since 1992, an initial AIR project developed collections, genetic studies, plant production methods, cultural models, a first description of walnut woods and a socio-economic study for private landowners. It provided all the basic elements for fully developing an extensive walnut culture in Europe and the background know-how for the present project which is focused upon the walnut wood as end-product.Five main factors affecting wood quality in walnut have been identified by industry : a) wood density dependingon tree growth; b) wood grain thinness; c) wood defects, especially by local dark necroses. These factors will be simultaneously studied to evaluate the whole walnut wood characteristics in order to be in good accordance with industrial concerns and to find relevant and objective characters of wood quality.New industrial options have emerged and have been well-defined in Italy by the company Segati Tranciati Industria Meridionale (Nola) : current industrial needs are concerned with the production of homogeneous light-coloured wood, with large growth rings and low density without heartwood for optimising and standardising end-products. This new situation led the 'European walnut group' to develop new strategies in forest a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Plant food allergies: field to table strategies for reducing their incidence in europe (SAFE)'.

assistant: **Objectives**

The EU is actively encouraging consumption of fruit and vegetable for positive health benefits. Apples are the most widely grown and consumed fruit in Europe, but around 1M people are apple allergic. A number of major apple allergens have been identified but detailed information on sensitisation patterns is lacking. Focusing on apple allergy the project will characterize allergens, and linkages with severe versus mild symptoms using fruit-allergic patients from acrossEurope.It will also provide the European Agro-Food industry with strategies tonsure the availability of high quality low allergen foods in European and export markets thus extending consumer choice of fresh or processed food stuffs with reduced or abolished allergen city. It will also supply the consumer with reliable and independent information about low allergenic alternatives (existing cultivars and GMO).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Self-disinfecting Photodynamic Catheters to Prevent Nosocomial Infections' (PHOTOCATH) under Horizon 2020.

assistant: **Objectives**

Catheter-associated urinary infections (CAUTIs) are among the most common nosocomial infections, leading to substantial morbidity and mortality. They prolong hospital stays and significantly increase the economic cost of the disease. Despite the many techniques that have been developed to prevent them, spanning from the training of health professionals to the intraluminal use of antibiotics or ""classical"" microbicide coatings, the problem is still largely unsolved. A smart strategy to address the problem would be the development of a universal microbicide coating that only exercises its effect on the indwelling catheter when activated with visible light travelling through the catheter itself, the latter playing as a hollow optical fibre if made of transparent polymer. In this context, we aim to prepare self-disinfecting photoactive (urinary) catheters using the advanced components that modern chemistry and technology provide us, namely, (i) low-power super-bright cheap LEDs and laser diodes, (ii) highly transparent biocompatible polymers (silicones), (iii) versatile surface functionalisation techniques (plasma, silanisation) and (iv) tailored photosensitising dyes capable of generating large amounts of singlet oxygen upon illumination. This reactive oxygen species leads to the destruction of the microorganisms and, therefore, the incipient biofilm (antimicrobial photodynamic inactivation, aPDI), leaving unharmed any cell not contacting the catheter. The combination of the researcher knowledge (photochemistry, dye derivatisation and photodynamic effect), and some of the strongest areas of expertise within the host groups and collaborators (applied photonics, silicones and microbiology), provides all the necessary tools to tackle this challenging interdisciplinary propo