RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ion beam techniques for the sub-nanometric characterisation of advanced energy conversion heterostructured materials' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The improvement, discovery or implementation of alternative energy sources represents one of the most dynamic and challenging trends in today´s research with connections to Materials Science, Applied Physics and Engineering, among others. In this context, current developments in high-efficiency energy conversion systems are based in the modification at the atomic level of heterostructured materials to improve the performance of devices such as solid oxide fuel (SOFC) and triple-junction solar cells (TJC). These two highly-engineered technologies demand specific analytical techniques with high spatial resolution to perform a chemical characterization capable of relating their structure and their functionality, particularly at the interfaces. In this project we will apply a novel instrumental configuration that combines surface science and surface analysis to probe materials surfaces and interfaces with unparalleled precision so that we will be able to better understand and optimise the materials we are developing. Two techniques, low energy ion scattering (LEIS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) are the best candidates to face such challenge due to their excellent surface sensitivity and depth resolution. The combined use of these ion beam techniques will provide an understanding of the surface and near surface processes in the latest generations of advanced materials. For this purpose, a deep understanding of the ion-solid interaction fundamentals is required in order to optimise the depth resolution and sensitivity of ToF-SIMS-LEIS to perform the most accurate and reliable analysis of the interfaces and nanometric domains in such heterostructured materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evolution of artificial enzymes for light-driven reactions by implementing unnatural cofactors in protein scaffolds' to be submitted under Horizon 2020.

assistant: **Abstract**

The LightZymes project aims to create artificial enzymes (LightZymes) catalyzing selective light-driven conversions of small organic molecules.Enzyme catalysis has a large potential in the development of a sustainable, bio-based economy and is increasingly applied on industrial scale. Nature’s repertoire of enzymatic reactions is huge, but for many reactions developed by chemists, no natural enzyme is available.I envision expanding the chemical diversity of enzymes to photoredox catalysis. Chemists perform this type of reactions by employing photo(organo) redox catalysts (PC). However, achieving regio- and stereoselectivities is challenging, because radical intermediates generated during the reaction are difficult to control. To solve this problem, I will combine the strength of bio- and photocatalysis: organic PCs as artificial cofactors provide new reactivities, and the proteins will be evolved to render the reactions highly selective. This approach differs from artificial photosynthesis: instead converting light energy in high-energy cofactors (NADPH, ATP), light will directly enable selective synthesis reactions.Efficient directed evolution requires an easy assembly of the catalyst, preferentially inside the cell. I propose to apply genetic code engineering and to supply the PC in the form of non-canonical amino acids (ncAA). Engineered amino acyl tRNA synthetases will incorporate the PC directly during ribosomal synthesis. This will facilitate–for the first time–the assembly of hybrid catalysts in the cytoplasm without needing further modifications or purifications. This opens the door for applying high-throughput screening based on mass spectrometry and FACS to generate highly selective variants. By bridging the concepts of photoorganocatalysis and biocatalysis, L
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SEcure Terminal IC (integrated circuit)' (SETIC).

assistant: **Concept**

For the secure exchange of critical data (like payment, e-commerce, banking but also handling of sensitive personal data) between a person and an automatic electronic processing system we need not only secure tokens like smart cards for authentication and key management but also as supplement a secure terminal.Typical terminals for such data exchange are:- Secure keyboards;- Online payment terminals;- Authentication and signature devices.Common to all this applications is the need for a secure, trustable device which can handle the necessary security protocols, interfacing easily to the communication infrastructure and communicating securely over a network or similar to the central control and processing system Within this Secure Terminal IC (SETIC) project we want to specify, develop and test with two real life application a single chip solution for this purpose. This stand alone single IC will be the readers security supplement to already existing secure smartcards.Objectives:Within this proposal we will develop out of a highly secure, advanced smart card processor kernel an universal Secure Terminal IC (SETIC). With this single chip solution it will become possible to develop in a simple and economic way terminals (for smart cards as well as for other security applications) with embedded security features. Specific firmware in the controller part of the module together with cryptographic coprocessors will provide the elementary crypto functions and also the low-level operating system routines. The practical usability together with the system features will be tested by different security applications like secure keyboard and secure on-line payment terminals. The overall security level will be analysed and certified by a Common Criteria evaluation. With SETIC the neces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evaluation of Beneficial Role of Protein Phosphatases and KLF2 in Diabetic Endothelial and Progenitor Cell Repair' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Type 2 diabetes has become one of the major causes of cardiovascular risk factor-induced mortality in recent years. The severe endothelial dysfunction associated with diabetes leads to both macrovascular and microvascular disorders culminating in atherosclerosis and foot ulcers. The specific molecular mechanisms underlying this impaired neovascularization are incompletely understood. One of the main hypothesis is an altered function of progenitor cells derived from the bone marrow in diabetes, associated with a decreased number and a dysfunction of proangiogenic mononuclear/endothelial progenitor cells (EPC). We propose that the easily obtained EPC from patients reflect the more general endothelial dysfunction of the adult vasculature. Previous work from our groups has shown beneficial effects of shear stress and KLF2 (Krüppel-like factor 2) on endothelial function and normalization of MAPK networks as well as the specific role of phosphatases like PTP1B in diabetes. The aim of our project will focus on studying activation pathways involving deregulated phosphorylation cascades. Especially the infrequently studied phosphatases known to take part in diabetic pathology will be monitored in EPC isolated from diabetic and healthy subjects. Next, altered MAPKinase and phosphates relays will be studied in in vitro culture modulated by small molecule inhibitors or lentiviral genetic modulation. Specifically, the beneficial role of shear stress and its linked transcription factor KLF2 on EPC function will be assessed. Finally, we will evaluate the therapeutic capacity of identified inhibitors of specific kinases and phosphatases as well as KLF2 after a genetic or physiological (shear stress) overexpression to normalize EPC/endothelial function in a mouse model of revascularizat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electric Vehicle Components for 1000 km daily trips (EVC1000).' to be submitted under Horizon 2020.

assistant: **Abstract**

The project brings together ten participants from industrial and academic backgrounds to provide innovative and mass-production optimised components enabling the efficient integration of powertrain and chassis systems, which will increase EV range and user acceptance. Given the recent progress related to in-wheel motors technology, and the benefits of in-wheel architectures in terms of active safety, packaging and drivability, EVC1000 will focus on in-wheel drivetrain layouts, as well as a wheel-centric integrated propulsion system and EV manager. More specifically, the consortium will develop: - New components for in-wheel powertrains: i) Efficient, scalable, reliable, low-cost and production-ready in-wheel motors, suitable for a wide range of torque and power specifications; and ii) Dual inverters for in-wheel motor axles based on Silicon Carbide technology. The designs will include detailed consideration and measurement of the electro-magnetic compatibility aspects, as well as the implementation of model-predictive health monitoring techniques of the electronic components.  - New components for electrified chassis control with in-wheel motors: i) Brake-by-wire system for seamless brake blending, high regeneration capability and enhanced anti-lock braking system control performance; and ii) Electro-magnetic active suspension actuators, targeting increased comfort and electric vehicle efficiency. - Controllers for the novel EVC1000 components, exploiting the benefits of functional integration, vehicle connectivity and driving automation for advanced energy management The new EVC1000 components will be showcased in two production-ready electric vehicle demonstrators of different market segments. EVC1000 will assess the increased energy efficiency and will include demons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-Discipline Design, Analysing Optimisation of Aerospace Vehicles' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This project has demonstrated the concurrent multi-discipline assessment of an aircraft in a matter of hours, thus providing the basis for two important new processes; Multi-Discipline Analysis (MDA) - the multi-discipline assessment of the performance of an aircraft to a consistent standard, allowing the effect of design changes proposed from any source to be rapidly evaluated. Multi-Discipline Optimisation (MDO) - the use of optimisation tools to repeatedly apply a proven MDA process and thereby evolve new and improved design options, according to design variables and constraints specified by the engineer. This MDO capability has been realised and made effective through the innovation of engineers in two key areas in particular; the Multi-ModelGenerator (MMG) which was devised and developed to enable the rapid and systematic generation of the complex analysis models required for high fidelity aerodynamic, structural and aeroelastic simulation of aircraft peformance, the Integrated Product Model (implemented in the Technical Data Modeller and Browser (TDMB)), that provides a structured data modelling methodology and practical data exchange and access utilities, enabling extensive multi-discipline technical data to be defined and managed effectively. These developments are considered to have provided the technology required to enable a step-change in the speed by which State-of-the-Art simulation tools can be applied repeatedly and systematically to assess the multi-discipline effect of design changes. Such work, involving specialists from multiple disciplines and from multiple companies, is believed to be unique.Objectives and content The increasingly competitive nature of the civil and commercial transport market leads the airlines to demand of the aircraft manufactur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of low electricity consumption water purification plants using renewable energies' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

In Europe's rural areas problems of drinking water quality are still existing. Many little villages and rural settings don't comply with standards particularly concerning biological parameters. Renewable energies should offer the possibility to purify this drinking water. Main objective of this research is the integration of renewable energies in biological water treatment systems in two ways: - Development of a pico hydroelectric system adapted to UV treatment - Development of stand alone photovoltaic UV treatment system (low electricity consumption, working following the demand). The different phases of this research will be: - Optimization and adaptation of UV treatment to renewable energy supply - Sizing of PV system including energy storage and sizing of pico- hydroelectric system - Realization of prototypes - Laboratory experiments - Design an sizing of complete treatment chain - Tests under real conditions of use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Cognitive aspects at issue in the processing of demonstrative expressions used anaphorically'.

assistant: **Objectives**

Although psycholinguistic studies dealing with the processing and the interpretation of anaphoric expressions are very numerous, very few of them have been interested in studying demonstrative expressions. However, the deictic component of these markers make them particularly original expressions for studying anaphora processing. It seems, indeed, that the presupposition constraints which regulate the functioning and interpretation of these expressions may be stronger than for other expressions more prototypically anaphoric like definite pronouns. The aim of the research project is to study the impact of the instructional value of both types of English demonstrative markers: demonstrative descriptions like that man, and demonstrative expressions like the former/the latter, on sentence processing within a discourse context. These demonstrative markers will be contrasted with definite pronouns like he/she, by manipulating the focusing of discourse entities in working memory (high-focused entity vs. low-focused entity) in two self -paced reading experiments, where only the gender cue will differ from one experiment to the other. By studying the specific constraints and their interactions (level of entity activation (focused entities), gender agreement, presuppositional constraints) on the functioning of these three types of expressions, this project aims to specify the cognitive mechanisms underlying anaphora processing. Within the context of her post-doctoral research project, Marion Fossard would benefit from high quality training within a stimulating and supportive department where all the members are actively engaged in research. She would participate in weekly seminars and colloquia series on a wide variety of topics. Furthermore, the psycholinguistics group has exten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Antibiotic resistance (AR) is spreading rapidly, leading to the development of highly virulent pathogens and multidrug-resistant ‘superbugs’, a major health concern of our era. Mobile DNA elements, transposons and integrons, effectively drive the spread of AR genes in microbial interaction hotspots, such as bacterial communities in humans and natural environments. Yet, our knowledge of their mechanisms remains very sparse. It is unclear how DNA movement occurs on the molecular level and how it is controlled in cells and communities; biochemical and structural data are rare and our view on their diversity and evolution is limited. Here I propose an integrated approach combining bioinformatics, genetics, microbiology, biochemistry, and structural biology to elucidate the mechanisms and diversity of mobile DNA driven resistance spreading. I want to (a) investigate the molecular mechanisms and regulation of AR gene movement in vitro, in model bacteria and in gut bacterial communities; (b) dissect the structure of the underlying molecular machineries to reveal how protein-DNA interplay promotes gene transfer; and (c) characterize the diversity, evolution and functional success of distinct molecular pathways. Mechanistic work will focus on selected mobile elements that confer resistance to last resort drugs and promiscuous gene carriers with high prevalence in health care. Bioinformatic quests will draw on recent (meta)genomic data to chart the clinical significance of molecular insights in situ. By bridging disciplines, I want to provide functionally annotated molecular movies of gene movement and explain how specific molecular strategies evolved to enable broad dissemination of resistance determinants. The insights gained in this research will provide in-depth knowledge on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Safe and Sustainable by Design framework for the next generation of Chemicals and Materials'.

assistant: **Innovation**

SSbD4ChEM brings together stakeholders from industry, government, academia, and civil society to develop and promote best practices for safe and sustainable product and process design, through demonstration in 3 case studies. SSbD4CheM aims to meet the EU's strategic objectives for digital, enabling, and emerging technologies, sectors, and value chains by developing a comprehensive Safe and Sustainable by Design (SSbD) framework that uses new science-based approaches to identify and address potential hazards and risks, and innovative technologies to support the design of safer and more sustainable products and processes. SSbD4CheM objectives include: 1) SSbD framework to facilitate development of the next generation of chemicals and materials applicable to renewable composites in automotive value chain, PFAS-free coatings for textile and cellulose nanofibers as additive in cosmetics to replace plastic microbeads, 2) Development of efficient hazard screening tools for alternative assessment of next generation chemicals/materials/products combining in silico tools and multicriteria analysis, 3) Advanced explorative ex-ante LCA method supported by molecular and data-driven modelling to fill  data gaps for (novel) materials and chemicals, 4) Integration of chemical/(nano-)material characterization  methods to assess  products’ environmental safety, quantify  emissions to support occupational and consumer  safety limits, 5) Development of alternative,  in vitro models, as part of New Approach Methodologies for adequate exposure scenarios, 6) Harmonization and validation of analytical and toxicological methods for proposition to regulatory and standardization bodies to contribute to the development of new standards and facilitate market acceptance of SSbD4CheM project results