RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neutrino Uncertainty Quantification using Neural Networks' under Horizon Europe.

assistant: **Concept**

Neutrino oscillation experiments are entering a new era of precision, utilizing cutting-edge technologies and capabilities to offer unprecedented insights The ERC project NUQNET aims to enhance the prediction accuracy of neutrino-nucleus interactions by implementing advanced machine learning techniques. This endeavor involves incorporating predictive errors, a critical step necessary to meet the requirements and fully unlock the discovery potential of upcoming neutrino oscillation experiments.Presently, there is no theoretical method capable of consistently describing neutrino interactions across the wide energy spectrum investigated in neutrino experiments. Moreover, existing models in the market rely either on some approximations or on semi-phenomenological approaches, making it challenging to rigorously assess the theoretical uncertainty. This uncertainty must be meticulously propagated throughout the analysis to extract precise oscillation parameters.The PI plans to go beyond the limitations of traditional many-body techniques by using ANN architectures to represent the nuclear wave functions and obtain the spectral function of several nuclei relevant for oscillation experiments (see next section for details). A novel methodology to incorporate quantum-mechanical effects into the description of final state interactions, a domain typically modeled by semi-classical intra-nuclear cascades in neutrino event generators, will be introduced. To achieve this goal, the PI will pioneer the development of a new real-time Variational Monte Carlo algorithm, building upon the formalism employed to obtain the ANN nuclear-wave functions. New tools will be developed to describe the high-energy region relevant for DUNE in which the degrees of freedom switch from nucleons and pions t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tracing the Invisible. Old Norse and Latin in medieval manuscripts.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In the project “Tracing the Invisible. Old Norse and Latin in Medieval Manuscripts (INVISIBILIA)”, I propose to investigate bilingualism in medieval Northern Europe by focussing on the most popular media of the time: manuscripts. I will trace their Latin components, which have mostly been neglected in research until the present day, and make them accessible to the scientific community digitally, thus providing essential texts and finding aids for the Latin sections. I will analyse the interaction of the Latin with the Old Norse texts. By relating them to the production, dissemination and use of manuscripts by people from different social backgrounds, I will give a deep insight into the European literacy of medieval Icelanders and Norwegians in the time span ca. 1100 – ca. 1500. INVISIBILIA will focus on the manuscripts held in the Arnamagnaean Collections in Copenhagen and Reykjavik, which represent approx. 90 % of the total number of Old Norse codices. Any exemplar containing both Old Norse and Latin as clearly distinct entities will contribute to the corpus of the study, about 400 manuscripts in total. I will approach this corpus according to three major research objectives, namely a full catalogue of the Latin entities, a comprehensive multi-level edition, and a comparative study. The results of the three research objectives will be integrated in an enhanced publication, realising the latest developments in Digital Humanities. This open access, on-line website will exchange data with existing scientific databases and make it possible for other scholars to collaborate actively. By spanning the borders between Traditional and Material Philology, Cataloguing and Editing, and Traditional and Digital Humanities, INVISIBILIA reaches out to scholars of medieval Scandinavia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Simplified and specialised hplc for diagnostic and environmental laboratory application' (1998-2002).

assistant: **Innovation**

Presently available High Performance Liquid Chromatography instrumentation (HPLC) are tailored to R&D applications and are not specifically designed for clinical-diagnostic and environmental fields analysis. The LAB-HPLC project proposes the development of a simplified, integrated and specialised HPLC. The proposed system will be:  integrated and compact: constituted by an innovative high pressure pumping system, gradient programming system, spectrophotometric/spectrofluorimetric detector, column thermostat, post-column reactor and accessories " applicable to 100% needs in clinic biochemistry and environmental analysis: combining optimised analytical programs and dedicated reactive Kits " flexible at broad spectrum: adopting optimised and ready to use reactive kits for each analysis of interest of the laboratory, the equipment allows to be used in standardised manner, independently by the operator and producing always the same quality of data. " user friendly, thanks to the standardisation of sample treatments"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ERA-NET Collective Research' (CORNET).

assistant: **Concept**

CORNET is dedicated to networking national and regional programmes and initiatives which support R&D and the dissemination of the results of that R&D to the benefit of large communities of SMEs. This is collective research. The defining characteristic of collective research is that the R&D performed is undertaken in the interest of a broad target group of firms, with the results being accordingly disseminated widely. Collective research provides an optimal means of responding to shared research needs of broad communities of firms, particularly SMEs with limited or no research capacity of their own. Collective research is generally associated with trade associations and/or research centres working on behalf of a particular branch or sector of the economy. This model operates successfully in several European countries/regions. It is, however, but part of a bigger picture. Modern innovation theory has encouraged policy approaches based on ideas of networking among firms, knowledge organisations and other institutions and organisations. Relevant concepts include: ?industrial districts?, ?regional innovation systems?, ?value chains?, and ?clustering?. Where governments promote R&D and knowledge transfer using such approaches, it is often to support what is in effect collective research. There is presently neither systematic exchange of experience between collective research programmes nor any concerted attempt to co-operate at a European scale. CORNET will bring together key players from 17 European countries/regions promoting collective research CORNET has several key strategic objectives: - To provide a forum for policy makers and programme managers to exchange experience and good practice. - To support policy makers in the new EU Member States, which have an urgent need t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of Polycomb Repressive Complex 2 (PRC2) in retrograde signalling' (PRC2).

assistant: **Innovation**

Polycomb Repressive Complex 2 (PRC2), as one of the most well-described Polycomb group (PcG) complexes, catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3) and represses transcription of target genes. It is a central regulator in multiple developmental processes and conserved across diverse eukaryotes. Recent results from the host lab suggested novel roles of A. thaliana PRC2 in retrograde signalling. To study retrograde signalling, chloroplast translation inhibitor lincomycin was revealed to affect plastid-encoded photosynthetic genes (PhAPGs) and nuclear-encoded photosynthetic genes (PhANGs). The mechanism of PhANGs repression depends on the optimal function of GENOMES-UNCOUPLED (GUN) genes and loss-of-function mutant gun1 fails to repress the PhANGs in response to lincomycin. Interestingly, I recently found that root growth of single mutants of clf-29, swn-3, double mutants of clf-29gun1-1, and swn-3gun1-1 is insensitive to lincomycin, and the mutants phenocopy gun1 upon lincomycin. However, how PRC2 involved in retrograde signalling remains unknown. Therefore, PRCretro project aims to understand the fundamental aspect of PRC2 in retrograde signalling by three WPs. PRCretro combines the applicant’s expertise in root-shoot communication and physiological studies with the host lab's expertise in developmental epigenetics. Together, PRCretro project will provide the first knowledge on epigenetic contribution and root-shoot communication to retrograde signalling. It will also establish the fundamentals for studying retrograde signalling and PRC2 in moss, laying the foundation for evolution studies. The research results of PRCretro project will be disseminated to the scientific community by submission of high-impact scientific articles and oral presentations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Comparative Genome Analysis in Dicotyledonous Crop Species and Arabidopsis' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The EuDicotMap programme is an integrated project designed to carry out the full range of research tasks associated with section 3.1.1.(Molecular genetic maps of the Biotechnology work programme). Its aims are to explore comparative mapping and exploit this across a broad spectrum of dicotyledonous plants both of economical and scientific importance. It is centered on the extensive use of Arabidopsis and rice to idendify highly conserved sequences within the ESTs and extends the exploitation of the ESSA project to a number of cultivated crops including Brassica, potato and aubergine, pea, Lotus and alfalfa, sunflower, lettuce and chicory, sugar beet and its wild relatives and Prunus. The programme adresses four main issues: a) Identification of conserved genes (at least 400) from EST databases, mapping them in Arabidopsis, and use as anchor loci in each major crop. This will provide a framework of common markers with identified functions as well as at least one dicotyledonous reference map. b) Mapping long-range synteny within crop families using the Arabidopsis anchor loci, exchanging markers already mapped in one of the species as well as mapping additional less conserved genes of common interest. c) Evaluating long-range synteny between Arabidopsis and the other crops and between the different families using the anchor markers and trying to define blocks of synteny which may allow reconstitution of the evolution of the various genomes. d) Evaluating synteny at the microscale level with well characterized regions of the Arabidopsis genome. Demonstration of such synteny will open the way for a genome shuttling cloning strategy for genes of agronomical importance. The expected deliverables are the following: a) a publicly available database of the set of universal ancho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Active Gurney Flap' (AGF), addressing dissemination and exploitation.

assistant: **Impact**

A huge effort has been dedicated to improving the performance of aircraft propellers, as well as of aerodynamics surfaces, having in mind the maximization of the overall efficiency and reduction of the fuel consumption.In that sense, blade morphing technologies have become a must for long term developments. In meanwhile, however, the effects of several smaller changes have been investigated with very good preliminary results, such as, Gurney flaps and other trailing edges.In this project, Active Space Technologies (AST) proposes to develop a new concept of an Active Gurney Flap (AGF) in collaboration with the Green Rotorcraft Consortium (GRC1). The project scope is the complete design and manufacturing of the controller, actuator and Gurney flap mechanism, which will be assembled in a set of four scaled model helicopter blade and tested in a wind tunnel. The AGF system must be compliant with a set of challenging system requirements related with the actuation frequency (60Hz), the required maximum deployed extension (3% of the blade chord), the limited available room at the flap location (about 1.5 mm) and the Gurney flap movement perpendicular to the blade surface.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interactive Toolset for Understanding Trade-offs in ATM Performance' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ATM performance results from the complex interaction of interdependent policies and regulations, stakeholders, technologies and market conditions. Trade-offs arise not only between KPAs, but also between stakeholders, as well as between short-term and long-term objectives. While a lot of effort has traditionally been devoted to the development of microscopic performance models, there is a lack of useful macro approaches able to translate local improvements or specific regulations into their impact on high-level, system-wide KPIs. The goal of INTUIT is to explore the potential of visual analytics, machine learning and systems modelling techniques to improve our understanding of the trade-offs between ATM KPAs, identify cause-effect relationships between KPIs at different scales, and develop new decision support tools for ATM performance monitoring and management. The specific objectives of the project are:1. to conduct a systematic characterisation of the ATM performance datasets available at different spatial and temporal scales and evaluate their potential to inform the development of new indicators and modelling approaches;2. to propose new metrics and indicators providing new angles of analysis of ATM performance;3. to develop a set of visual analytics and machine learning algorithms for the extraction of relevant and understandable patterns from ATM performance data;4. to investigate new data-driven modelling techniques and evaluate their potential to provide new insights about cause-effect relationships between performance drivers and performance indicators;5. to integrate the newly developed analytical and visualisation functionalities into an interactive dashboard supporting multi-dimensional performance assessment and decision making for both monitoring and mana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Linking glutamatergic spinal cord and brainstem neuronal circuits to the control of locomotor behavior' (NEURONSINMOTION).

assistant: **Concept**

Locomotion is an essential motor act that for the most part is controlled by neuronal circuits in the spinal cord itself, called central pattern generators (CPGs), although their activity is turned on from centers in the brainstem. Understanding the operation of CPG circuits in mammals has been a significant challenge to neuroscientists over the last 50 years. The CPG for walking generates rhythm, as well as the precise patterns of muscular activity. The neural assembly that is directly involved in generating the locomotor rhythm is completely unknown. There is strong evidence from pharmacological and lesion studies showing that glutamatergic neurons are responsible for this function. Here, I propose to identify these key glutamatergic neuronal CPG circuits. As a first step we will use state-of-the-art RNA-sequencing to obtain the complete transcriptome of glutamatergic subpopulations in the ventral spinal cord of the mouse to define new postnatally expressed molecular markers. To link glutamatergic neuronal subpopulations to the locomotor behavior we will use transgenic mouse systems to incorporate light-activated switches in a cell specific way. These tools will provide a new basis for functional and network studies needed to understand the CPG operation. We also propose to use mouse models with optogenetic switches to provide a molecular identification of the glutamatergic locomotor command systems and their integration in the CPG. Our analysis will provide a unified characterization of the neuronal organization of the mammalian CPG and its immediate control from the brain. Understanding the locomotor CPG and its control in mammals is of outmost importance for improving rehabilitation of spinal cord injured patients and designing new repair strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innate signals for brain homeostasis' (2002-2006).

assistant: **Innovation**

Interaction between the immune and nervous systems is critical for repair, tumour surveillance and protection from infection. Toll-like receptors are evolutionarily ancient pattern-recognition receptors that are implicated in innate responses to infection. In work done in Canada we have shown that signals delivered through the Toll-like receptor-2 (TLR2) are critical for early microglial response to experimental brain injury. Microglia are macrophage-like cells in the brain and spinal cord that act as rapid sensors of loss of homeostasis of any kind. Activated microglia can recruit T cells and macrophages to the central nervous system via production of chemokines and cytokines.Our findings suggest that endogenous ligands for TLR2 are produced within the brain independent of infection and these ligands direct microglial response. This represents a novel role for TLR's in brain function. In Denmark, we propose to identify TLR2 ligands that are produced in response to injury in the mouse brain. Localized axona l degenerative injury will be used to induce TLR2 ligands. These will be assayed for their ability to induce intercellular signals, and mRNA and protein for specific cytokines and chemokines in microglial cultures.Criteria for functional TLR2 ligands will include purification with TLR2-Fc but not TLR4-Fc fusion proteins, and induction of responses in wild-type but not TLR2- or signalling-deficient microglia, that are blocked with TLR2- specific reagents. Ligands that meet these criteria will be characterized by proteomic analysis including 1- and 2-D gel electrophoresis, immunoblotting and mass spectrometry. Ligands are expected to be lipoproteins or peptidoglycans - our assays will detect both. Ligand-specific monoclonal antibodies will be generated and used to prob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sensing Biosystems and their Dynamics in fluids with Organic Transistors' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The vision of BIODOT is a hybrid bio-organic technology for transduction of dynamical phenomena of biosystems in-vitro. The device that will be developed is based on organic ultra thin film transistors integrated with microfluidics. It will respond to subtle changes of the electrostatic charge at the interface between the biosystem in the solution and the organic semiconductor. These changes are due, for instance, to the flow of ions, the adsorption and diffusion of charged or polarisable molecules, the motion of large biomolecules, the activity of cells grown on the organic semiconductor.The transduction of the dynamical behaviour of:a) peptides involved in neurological functions,b) phospholipids and functional membranes,c) neurons and glia cells will be demonstrated during the project.The signal will be correlated with dynamical data from fluorescence and scanning probe microscopy, computer simulations and structural techniques at the micro- and nano-scales. The integration of neural cells into this technology will extend the scope of the project towards long-term applications in biomedicine. These and other aspects make BIODOT a project aimed to achieve breakthroughs with respect to the state-of-the-art.