RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum-enhanced on-chip interference microscopy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proposed project aims at developing a new on-chip differential interference contrast microscope based on an unconventional birefringence lens-free configuration, the latest quantum sources and single-photon image sensors. The Q-MIC platform will reach unprecedented sensitivities (a few atomic layers, of the order of 1 Å) over large field-of-view (tens of mm2) in the low light (single-photon) regime. This unique combination of features will allow, on the one hand, the first demonstration of a practical quantum device for imaging, while providing, on the other hand, a platform for fundamentally new lines of re-search in quantum metrology, including the interaction of quantum states and bio-species. It is also an important goal of the project to facilitate that the quantum enhanced on-chip interference microscope be built with consumer components, especially thanks to the project’s effort in photonic and electronic inte-gration of entangled photon sources and single photon avalanche diode image sensor arrays. This would extend the impact well beyond the scientific interests and lead to portable, high throughput, non-invasive, and label free sensing of transparent objects, such as cells, micro-organisms, viruses and proteins. For ex-ample, microarrays of biomarkers with millions of spots could be read in a single shot, with no need of fluorescence marking. Other applications include the detection of small particles in the microelectronics industry and in-line quality control of transparent substrates for roll-to-roll production of flexible optoe-lectronic devices. The Q-MIC consortium includes four academic and two industrial partners with a high degree of complementarity that are at the forefront of their fields, including photonic devices (ICFO), optical engineering (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Interfacial Electrochemical Bacterial Recognition' (INTERBAC), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to investigate fundamental aspects of the physical chemistry of bacterial cell / substrate interactions. Well-defined surfaces of both single crystals and multilayered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry by capacitance measurements. The use of single crystal electrodes is essential in order to avoid the uncertainties of classical electrode surfaces that have a surface rugosity of the same order of magnitude as the dimensions of the bacteria investigated. This will ensure a high degree of control and reproducibility of the electrode material. The potential dependence of bacterial attachment and biofilm formation on these surfaces will be studied by microgravimetry, infrared reflectance spectroscopy and ac impedance spectroscopy.   The results will be used to develop an interfacial model of the potential distribution and therefore to calculate the interfacial capacitance of the cell membrane-interstitial solution- metal surface. Escherichia coli cells will be used to exploit the metabolic change during the aerobic / anaerobic transition in order to determine the influence of metabolism on interfacial electrochemistry. Feeding with nutrients of different energetic yield will also be used to produce differential metabolic states. In addition, specific bacterial attachment to gold surfaces will be directed by surface modification with thiols containing a recognition termination. Live and dead cells will be used in the bacterial recognition experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unraveling the functional architecture of the human thermoregulatory system through immunological, circadian and sensory mechanisms: focus on the mature European population' (THERMOMICS).

assistant: **Innovation**

Thermoregulatory abnormalities are major public health issues during exposure to heat stress, particularly for the elderly. Thousands of deaths among the mature have been attributed to heat waves that encompassed Europe recently, while an increase in heat-related deaths is projected due to global warming. Exertional heat illness and death among highly motivated athletes and soldiers also occur frequently, particularly since the deployments of European soldiers to Afghanistan and Iraq. The current proposal addresses mechanisms that may explain the sequence of events leading to heat stroke and death. The project’s main objective is to identify whether the regulated index of human thermoregulation is temperature- of heat-based by applying thermal stimuli in different bodily systems while making precise time-based measurements of temperature and heat storage. Apropos, the letters ‘ICS’ in the proposal’s acronym ‘THERMOMICS’ indicate the immunological, circadian and sensory systems that will be investigated, while ‘M’ refers to the mature population that the novel knowledge will be applied to. The potential benefit from this research is vast because it will help us understand the pathophysiological mechanisms related to thermal stress and relate the progressive changes in the thermal strain to inflammatory responses, and effects on the circadian rhythm and the sensory system. The fellow researcher has a true thirst for scientific research and is a highly accomplished individual at his stage of career development with the personal and intellectual qualities to thrive in any research environment. He has already received an Assistant Researcher offer by the host institution, a state of the art facility encapsulating pioneer researchers of high caliber. The thriving collaboratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Broiler breeder production - solving a paradox', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

To compete more effectively, the EU poultry industry needs to improve the production system of broiler breeder hens and the quality of the resulting products. Breeder hens overeat, become fat, suffer various pathologies and have poor reproductive ability. Severe rationing improves their health and reproduction, but current rationing regimens cause undue hunger. Product quality and the hen's welfare needs may be adversely affected by rationing. This project's objectives are:- To improve product quality and welfare of breeder hens under feed restriction.- To understand the interaction between reproduction, feeding, metabolism and welfare in broiler breeders.- To find genetic potential for improving product quality and welfare of broiler breeder hens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'The value of renewable electricity'.

assistant: **Innovation**

Objectives The primary objective of the project is to calculate the value of renewable electricity, using several techniques, in different European electricity systems and under different circumstances. This is important for renewable electricity because it will illuminate the price at which renewables are competitive without subsidies with other sources of electricity. The market for renewables and the rate of installation should increase. This has a number of follow-on effects: 1. it supports distributed electricity production 2. it supports independent power production 3. it is likely to increase rural jobs thereby supporting the rural economy 4. it is likely to increase manufacturing jobs for renewable technologies 5. it will reduce pollution Technical Approach RE-VALUE will assess the value of renewable electricity through three different methods: 1. A cash flow analysis which will examine the system average costs and allocate these to different constituent components. 2. A tariff analysis which will examine published variations in value components within countries and regions. 3. A market price method which will compare output data with variations in market price and local demands to correlate these variables. The project will consider two other areas where the value of electricity is particularly high: island systems, where renewables have already made a contribution; and rural networks where renewables could save grid-reinforcement costs. The results of these studies will then be compared to value studies in European and American literature and to empirical examples employed within North American electricity utilities. Expected Achievements and Exploitation The Final Report will synthesise and appraise these different approaches and illuminate the value of renew
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a fast optical 3d-scanner with micromirror array for illumination and detection' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

ObjectivesDuring this project a new technology for the 3D-inspection of small parts following the principle of confocal imaging will be built up and analysed. The key part will be a so-called Digital Micromirror Device (DMDTM), consisting of 864x576 programmable mirrors. Each of these has dimensions of approx. 13 x 13µm2 and can be set to an angle eighter -10 or +10 . So, every mirror element of the DMD inherently represents a pinhole. One DMD can be divided into two sub-arrays of micromirrors, that can be combined to obtain one confocal measurement system itself. The first is used as the illumination part, the second as the detecting part. Thus, using the whole aperture of the DMD, an amount of some ten confocal systems can work in parallel. This new approach does not scan the specimen using only one point as current systems do, as it allows scanning with some ten to hundred points. The following specifications shall be reached during the project:* measurement duration: in the range of seconds * measurement volume: ranging from 10 x 10 x 5mm3 to 10 x 10 x 5µm3* accuracy: ranging from 0,1µm to 10nm depending on the measurement volumeBackgoundMicro-System-Technology (MST) is currently in the state of extensive research. With the rescaling of the dimensions in MST the demands concerning the shape and surface quality of future products will increase steadily. As small and medium enterprises will be a main force in the field of MST in the next 5 to 10 years due to their higher flexibility, it will be essential for them to be offered an adequate measurement system that sufficiently satisfies their demands. Systems available at present, like for instance fringe projection systems, are, mostly, not able to fulfil all demands as they are too expensive, one the one hand, or too
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'COmputational DEsign for 4D BIOfabrication: harnessing programmable materials for dynamic pre-clinical cancer models' (CoDe4Bio).

assistant: **Innovation**

Cancer is a global health burden. In-vitro pre-clinical models play a key role in fighting this burden by encompassing all the activities prior to clinical trials, from tumor microenvironment reconstruction to drug candidate selection. However, the frequent failure of promising pre-clinical drug candidates highlights two major drawbacks of these models: (i) the difficult reproduction of the dynamic cancer structure related to numerous physical cues; (ii) their experimental nature that suffers from high costs, long times, and limited understanding. Consequently, the relationship between dynamic physical cues, cell behavior, and drug efficacy is still unknown. CoDe4Bio tackles such a huge knowledge deficiency. We propose a radical methodology shift to a computational approach to harness programmable materials, able to change properties on demand, and realize dynamic 4D biofabricated models whose stimuli-triggered evolution over time (4th dimension) induces targeted physical cues on cancer cells. We will leverage my extensive experience with smart materials and structures to address the challenges of this multidisciplinary project. Specifically, we will develop a computational design framework for 4D biofabrication that combines new data-, geometry-, and model-based methods with additive manufacturing and in-vitro observations. This framework will allow us to develop customized stimuli-responsive materials and engineer a new generation of 4D constructs with programmable mechano-structural properties and acting as mechanical regulators. We will assess the constructs in-vitro on chronic lymphocytic leukemia to achieve a deep understanding on how complex physical cues within lymph nodes and bone marrow affect this incurable cancer in relation to chemoimmuno and targeted thera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stromal reaction' in the context of a Fifth Framework call.

assistant: **Objectives**

The formation of a stroma comprising vascular structures and fibroblasts is a basic mechanism for a number of physiological and pathological processes such as wound healing and repair, inflammation and tumour formation. It has become evident in particular that the behaviour of tumours is not only determined by the neoplastic cells themselves but to a great deal also by the tumor stroma which plays multiple roles for tumour growth and propagation.Important are not only tumour angiogenesis (a prerequisite for continuous tumour growth) but also lymphangiogenesis (the basis for lymphatic spread of neoplastic cells) and a contribution of stromal fibroblasts to tumour invasion through the secretion of matrix-degrading proteases. Interactions between tumour cell integrins and the extra-cellular matrix is an important mechanism of tumour cell migration. Stroma formation also plays a major role for many non-neoplastic diseases. In rheumatoid arthritis inflammatory angiogenesis contributes to the perpetuation of the disease and a protease-producing fibroblastic pannus destroys the joints. The main problem of diabetic retinopathy is enhanced blood vessel formation. Stroma is finally indispensable for the re-vascularization of ischemic necrosis such as myocardial, brain or extremity infarcts. The molecular mechanisms underlying stroma formation have therefore become an important field of research in recent years carrying the potential for many novel therapeutic strategies among which are the application of recombinant growth factors, gene therapeutic approaches and the development of small molecular compounds which are particularly important for the modification of intracellular signal transduction or the inhibition of matrix degrading proteases. Not only academic institutions but
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Process oriented methods and tools for knowledge management' (PROMOTE) under Fifth Framework.

assistant: **Objectives**

The overall goal of PROMOTE is to adapt the existing Business process management systems methodology" (BPMS), for Process Oriented Knowledge Management, to validate it by developing a prototype named "Process Oriented Knowledge Management System" (PO-KMS), and to test it in three end-user companies from the financial sector, thereby realising a "full cycle". PO-KMS guides the accumulation, retrieval and distribution of product-process related knowledge and employee's know how, and serves as an on-line support tool for knowledge managers as well as for the employees who generate and use knowledge.The process based knowledge management approach is applied to three main areas, the business processes required to deliver the products/services, the product development process and the human capital of the company. Such a division covers important parts of the strategic, operational and human resources aspects of knowledge management.Work description:PROMOTE adapts the existing "Business process management systems" (BPMS) methodology in order to support process oriented knowledge management, validates it by developing a prototype named "Process oriented knowledge management system" (PO-KMS) and tests and evaluates it in three end user companies in the financial services sector.PO-KMS guides the accumulation, retrieval and distribution of product-process related knowledge and employee's know how, and serves as an on-line support tool for knowledge managers as well as for the employees who generate and use knowledge.The BPMS methodology has been successfully applied and validated in the past in the financial services sector. It provides a holistic framework under which a company sets its strategic objectives, reorganises its operations, allocates human and technological resources
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Foundations of Algebraic and Dynamic Data Management Systems' (ALGILE), addressing dissemination and exploitation.

assistant: **Impact**

Contemporary database query languages are ultimately founded on logic and feature an additive operation – usually a form of (multi)set union or disjunction – that is asymmetric in that additions or updates do not always have an inverse. This asymmetry puts a greater part of the machinery of abstract algebra for equation solving outside the reach of databases. However, such equation solving would be a key functionality that problems such as query equivalence testing and data integration could be reduced to: In the current scenario of the presence of an asymmetric additive operation they are undecidable. Moreover, query languages with a symmetric additive operation (i.e., which has an inverse and is thus based on ring theory) would open up databases for a large range of new scientific and mathematical applications.The goal of the proposed project is to reinvent database management systems with a foundation in abstract algebra and specifically in ring theory. The presence of an additive inverse allows to cleanly define differences between queries. This gives rise to a database analog of differential calculus that leads to radically new incremental and adaptive query evaluation algorithms that substantially outperform the state of the art techniques. These algorithms enable a new class of systems which I call Dynamic Data Management Systems. Such systems can maintain continuously fresh query views at extremely high update rates and have important applications in interactive Large-scale Data Analysis. There is a natural connection between differences and updates, motivating the group theoretic study of updates that will lead to better ways of creating out-of-core data processing algorithms for new storage devices. Basing queries on ring theory leads to a new class of systems