RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Single-Cell Transcriptomics and Spliceosome analysis to uncover new mechanisms of neuronal vulnerability to Huntington’s Disease.'.

assistant: **Innovation**

Huntington’s disease (HD) is neurodegenerative disease caused by a CAG repeat expansion mutation in the HTT gene. The pathological process, which ultimately leads to neuronal loss mainly in the caudate and putamen, is induced - in a truly dominant manner - by a single copy of the mutant allele. Transcriptional deregulation has becoming a prevailing feature in HD and changes at single-gene level in RNA biogenesis and aberrant alternative splicing (AS) events have been associated to neuronal vulnerability. Here, I propose to disentangle at genome-wide level the connections between mutant huntingtin expression and RNA processing, and its implications for neuronal vulnerability to death. Specifically, I propose to study alterations in RNA transcription and AS in: Aim 1. Striatal, cortical and cerebellar areas of Hdh knock-in (KI) HD accurate mouse models through global RNAseq; Aim 2. In specific medium spiny neurons (MSN) of the Drd1 or Drd2 direct and indirect pathways of Hdh KI striatum through laser capture dissection and single-cell RNAseq. The present research proposal represents a synthesis of my interest, expertise in RNA regulation, genome-wide approaches and single-cell analysis in the context of neurodegenerative disorders with my most recent exposure to human genetic. On the other hand, at the CIBIO host institution I will greatly benefit from the scientific exchange with the PIs of the neurobiology area, and my supervisor in particular, whose skills in neuroscience, neuroanatomical and behavioral analyses will perfectly blend and consolidate my cellular and molecular expertize. Thus, I believe I am optimally positioned to accomplish the aims of the current application: the MSCA-RI-IF will be instrumental to develop this initial hypothesis into deeper biological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microfluidic total analysis system for the early diagnostic of neuro-degenerative disorders' (NEUROTAS).

assistant: **Concept**

The project aims to develop a prototype of a miniaturized system for diagnostics in the early stage of Alzheimer disease and other neurodegenerative diseases, or as a point-of-care instrument for patient follow-up. The system to be developed belongs to the emerging field of 'lab-on-chip' systems. It incorporates several innovative enabling technologies, including microfluidic flow control, highly sophisticated nanobiodevices with integrated detection, and novel magnetic nanoparticles. These approaches will lead to unprecedented integration and automation, and allow routine implementation of tests that can presently only be performed in a small number of specialized research laboratories. The system will use biomarkers present in blood, such as differently cleaved b amyloid peptides and post-translational modifications of the Tau protein. The miniaturization and integration of innovative detection technologies will greatly extend the sensitivity of biomarker detection, and thus improve the precocity of diagnosis. This is of paramount importance for the treatment of neurodegenerative diseases, since therapeutic approaches able to retard the evolution of the diseases are progressing and promising, but little hope exists for the repair of existing brain damage. The method will also allow the simultaneous study of a wide range of markers, improving the early discrimination between different neurodegenerative diseases, and thus the choice of treatment. Indeed, the NeuroTAS system will have a modular and evolutive structure, and it will be able to progressively test and integrate into its diagnostic scheme new biomarkers that may be discovered during the prototype development. The consortium is a combination of 4 academic, methodology-oriented laboratories with complementary c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ImProvements of industrial Real Time Embedded SysTems devel0pment process' (PRESTO) under Seventh Framework.

assistant: **Objectives**

The PRESTO project aims at improving test-based embedded systems development and validation, while considering the constraints of industrial development processes. This project is based on the integration of (a) test traces exploitation (generated by test execution in the software integration phase induced by the industrial development process, to validate the requirements of the system) along with (b) platform models and (c) design space exploration techniques. The expected result of the project is to enable functional and performance analysis and platform optimisation at early stage of the design development. The approach of PRESTO is to model the software/hardware allocation, by the use of a modelling framework based on the UML profile for model-driven development of Real Time and Embedded Systems (MARTE). The analysis tools, among them timing analysis including Worst Case Execution Time (WCET) analysis, scheduling analysis and possibly more abstract system-level timing analysis techniques will receive as inputs on the one hand information from the MARTE performance modelling of the HW/SW-platform, and on the other hand behavioural information of the software design from tests results of the integration test execution. Of particular novelty in PRESTO is the exploitation of traces for the exclusion of over-pessimistic assumptions during timing analysis: instead of taking all possible inputs and states into account for a worst-case analysis, a set of relevant traces is analyzed separately to reduce the set of possible inputs and states for each trace.A particular attention will be given to industrial development constraints, which means 1) as little cost as possible in term of extra specification time and need of expertise, 2) a simple use of the tools, 3) a smooth int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New speakers and use of Russian in the Northern Norway' in the context of a Horizon 2020 call.

assistant: **Objectives**

The NEW_WAY project will look at trajectories across the lifespan among Russian-speaking linguistic actors, and on the role of speaking/writing Russian in the political economy of Northern Norway around the Russian-Norwegian border. With the end of Cold War and implementation of more flexible border policies, Northern Norway, as other regions neighbouring with ex-USSR, got placed into the heart of geopolitics, global migration and sea trade, security and environmental crises. In the two decades after the Warsaw Pact dissolution, use and acquisition of Russian by different social actors, including speakers of other languages, has renewed its significance in the multilingual economy of the region. With this MSCA action, I would bring my competence on biographical research, knowledge of Russian and expertise on Russian-speaking migrant communities to complement the Norwegian research team. I wish to expand the biographical workshops methods with nexusanalysis supervised by the world-renowned expert in nexus analysis. I will gain understanding of Northern borderland multilingual policies and practices in order to reveal deep-running social processes present and past (e.g. legal recognition, language investment and commodification, identity and community building etc.) with implications for social cohesion and peaceful neighbouring policy across other borderlands in Europe, as well as with potential for theory building and terminology creation. The project is expected to open ways to understanding the dynamics of decision-making that multilingual speakers undertake in investing into and building their individual language repertoires. Building from multi-sited ethnographic and biographical accounts, the project has a potential to construct a holistic perspective on multilingu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulating Retail Finance' (RRF).

assistant: **Innovation**

The proposed research falls into the fields of microeconomic theory and finance. The research team will develop novel modeling approaches that are suitable to study the scope and nature of (optimal) regulation in the retail financial industry, serving private households  investment, savings and borrowing needs. Next to this, there is also the goal to use a rich set of locally available data that allows testing many of the developed hypotheses. The core part of the research draws on and contributes to modeling approaches in the following fields, in which the PI has also expertise and reputation: finance, information economics / agency theory and industrial organization. Combined with very recent own research, this will allow to build models that fit the characteristics that are pervasive to the retail financial industry: first, the often extremely limited knowledge and experience of households ( financial literacy ); second, the large extent to which households, therefore, rely on third-party advice; third, profound differences in existing regulatory approaches but also, in particular in Europe, in the  industrial organization  of these industries (e.g., in terms of vertical integration of distribution channels) and in  market outcomes , as measured, for instance, by retail financial innovations, household participation, the size and composition of household debt or the nature of contracts (e.g., fixed vs. variable interest rates). The funded research together with complementary parts that are already in place will allow to generate a critical mass of research at the highest level and with high visibility, given that the area is heavily underresearched but of high policy relevance. The overarching long-term objective is to create a centre for the microeconomic study of r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fast-tracking Offshore Renewable energy With Advanced Research to Deploy 2030MW of tidal energy before 2030' (FORWARD-2030) targeting Horizon 2020.

assistant: **Abstract**

There is 10 GW  of predictable, high value tidal stream potential in European waters, with up to 100 GW  of capacity globally. It is an entirely unharnessed resource, with just 13 MW currently deployed .    FORWARD-2030 has an overall objective to fast track 2030MW of tidal energy deployment by 2030. The project has five specific objectives:1.Reducing Levelised Cost of Energy (LCOE) from ?200/MWh to ?150/MWh, 2.Enhancing environmental and societal acceptance,3.Complete industrial design for volume manufacture rollout for 10 and 100+ MW projects,4.Reducing life cycle carbon emissions by 33% from 18 gCO2 eq/kWh to 12 gCO2 eq/kWh,5.Enhancing commercial returns and energy system integration (with battery storage and green hydrogen production).Objective 1 is focused on fast-tracking innovation to support the development of a technically and commercially viable tidal energy solution by rapidly reducing LCOE. This will be achieved by developing and verifying seven high priority cost reduction innovations to reduce CAPEX, reduce OPEX, increase efficiency and increase availability.Objectives 2, 3, 4 and 5 are focused on the regulatory and commercial barriers that must be overcome to achieve the project vison of installing 2030MW of tidal energy by 2030. It will be achieved by developing three market uptake innovations: an integrated environmental monitoring system, an energy management system, and an operational forecasting tool. Four market rollout initiatives will be completed: a supply chain plan for large scale roll out, Societal Cost of Energy (SCOE) assessment tool, marine spatial planning to encompass floating tidal and a life cycle carbon reduction assessment.


**Keywords:** tidal stream energy, energy systems, power-to-x
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bioenergy retrofits for Europe’s industry' (BIOFIT).

assistant: **Concept**

One way in which bioenergy production can be increased is through retrofitting, the addition of new technology or features to existing industrial installations. Retrofitting means often lower capital expenditure (CAPEX), shorter lead times, faster implementation, less production time losses, lower risks and therefore faster project development and increased market benefits. BIOFIT aims to facilitate bioenergy retrofitting in five industries: first-generation biofuels, pulp and paper, fossil refineries, fossil firing power and combined heat and power plants. First an overview will be made of existing options for retrofitting, and best practices analysed, to establish (both technical and non-technical) success factors. This will constitute the basis for two core project actions i.e. the development of 10 concrete bioenergy retrofitting proposals (2 each per industry) and the establishment of dedicated working groups for each industry (industry platform) to facilitate two-way dialogue. Both actions will be industry-driven, and focus on identifying and helping to solve actual – general and industry-specific – barriers towards wider market uptake. BIOFIT will give specific attention to generating information for policy development. Acceptance of bioenergy, both by the industries and by the general public, is key to the industries’ transformation towards sustainable bioenergy generation and market uptake. Research into acceptance factors is an integral part of project set-up. Key issues will be highlighted, and guidelines for industries will be issued. The BIOFIT consortium is a multidisciplinary partnership, with strong industrial involvement, broad coverage across Europe, and existing practical experience developing bioenergy retrofits. The expertise of the consortium cover
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a scalable respiratory diagnostic platform' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Chronic respiratory diseases affect 10% of people and are the third cause of death worldwide. They cause significant disability and social exclusion. A key problem is the large under and misdiagnosis of such diseases. Late diagnosis of the diseases leads to lack of treatment and a rapid decline of the disease causing severe exacerbation, frequent hospitalization and high mortality with huge costs to the healthcare systems.Through design thinking and lean methodology we discovered a market opportunity. The current tools in primary care are not suited for non-specialists to tackle lung disease diagnosis. They require difficult breathing procedures from the patients, leading to inaccurate tests and incorrect diagnosis. It also creates mistrust in the technologies leading to underdiagnosis through lack of testing.Our solution is a quick, easy and accurate tool that doesn't require patient effort. It can be used in any clinical setting, but is particularly suited for non-specialists in primary care for disease diagnosis and monitoring. The output is trained on the lung experts' decisions, providing a diagnostic support tool for quick and effective decision-making where it is needed most. Early diagnosis and follow-up allows clinicians to intervene and educate the patient when treatment can still have a positive effect on their lung function and reduces the huge burden to the healthcare system due to avoidance of the severe stages of the disease, saving an estimated 5 BN € in the EU from hospitalizations alone.The WomenTechEU program provides the unique opportunity to test our technology in the clinical setting to reach a TRL5/6 from current TRL4 and protect our intellectual property. It also means we can strengthen our gender and diversity hiring processes and develop our le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Attractive REsearchers in the Spotlight' in the context of a Horizon 2020 call.

assistant: **Objectives**

ARES (Attractive REsearchers in the Spotlight) is a project that unites six of the biggest Universities and Research Centres in Greece. ARES aims at organising six European Researchers’ Night events in 6 big cities (Athens, Thessaloniki, Patras, Heraklion, Larissa and Rethymnon) geographically covering Greece from north to south and demographically covering more than 60% of the Greek population. Thanks to a multi-channel marketing strategy comprised of a multitude of traditional and modern tools, a strong and extensive network of collaborators and the availability of hundreds of researchers, ARES’ ambition is to get into the households of two million citizens inviting them in the Nights while spreading the key messages of the ERN initiative such as the high-quality research that is conducted in Europe and its importance for our everyday life. Researchers of different career stages and profiles will present their work by visiting high-schools, through radio/TV interviews and will take part in intriguing pre-events that ARES will organise. This active involvement of researchers, selected also for their high communicative skills, will assist ARES in achieving one more goal; successfully fight the stereotype of the boring, male, researcher with the eccentric look that works in dark labs misusing technology for world domination. During the Nights, an array of activities, mostly led by researchers, is foreseen. Exhibitions with hundreds of technological products, hands-on experiments, scientific demonstrations, activities designed specifically for kids in the presence of distinguished researchers and with the engagement of university students, combined with various entertaining activities will give visitors the opportunity to delve into the amazing world of research. Thanks t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'The dynamics of European integration. Intistutional or policy effects in European legislation'.

assistant: **Concept**

European integration, often defined by and understood as a 'process whereby two or more actors form a new actor' (Galtung 1968: 377), promotes two lines of arguments: The first, the 'form follows function'-hypothesis, focuses on the material integration effects of sensitive policy domains which themselves were partially or exclusively regulated by European politics (Mitrany 1975, Haas 1958). The second, the 'function follows form'-assumption, emphasises the integrative impact of European institutional settings. Both arguments, the material and the institutional, have often been used for the explanation of either the constitutional or the operational European integration, but seldom applied to empirical analyses. This study focuses on the theoretical and empirical analysis of operational European integration which concerns the internal integration by regular European legislation. Operational integration itself is measured by the amount, and the duration, of collective European decision making. We will be asking whether European legislation can be explained more by institutional variables than by material variables. The empirical part will cover more than 30 years of European legislation. To be more precise, our data analysis will be based on a sample of 6800 legislative proposals initiated by the Commission under various procedural rules and in different European policy domains. Our first part of analysis will refer to policy-specific effects on European legislation. Although some policy domains are formally controllable at the European level, they are seldom negotiated here, whereas other domains tend to be over-regulated by European politics. As a consequence, our first empirical step will take into account the regulation densities of different European policy domains.