RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering the role of RNA biological noise in aging using long-reads transcriptomics.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ultimate goal of this proposal is to decipher the role of the RNA biological noise (RBN) in the ageing brain. RBN represents a rare but real pool of RNA molecules generated as a result of transcriptional instability. However, as the RBN can only be extracted by full-length single-molecule transcript sequencing, whether RBN is associated with decline processes such as aging and neurodegeneration, remains to be elucidated. To evaluate this association, I will use readily-available data, including long-reads, single cell and spatial transcriptomics of aging mice brains. First, I will develop a methodology to distinguish technical noise from RBN in long-reads transcriptomics. Second, I will characterize the RBN to decipher its contribution to aging. Third, I will study the cell-type-specific and brain-region-specific RBN. To carry out this project, I will work with Dr. Conesa, expert in long-reads transcriptomics, method development and multi-omics. This timely work will benefit from collaboration with world leaders in single-molecule technologies participating in MSCA-DN 2021 “LongTREC” to study transcriptome biology under the coordination of Dr. Conesa. Successful completion of this project will contribute insights and software to understand the RBN across the single-molecule transcriptome, not only in the context of aging and neurobiology but also for researchers to use in other biological contexts. This project could also set important first steps towards better health, healthy aging, and a decrease in avoidable neurodegeneration.


**Keywords:** Aging, Neurobiology, Long-reads transcriptomics, Modelling, Biostatistics, Bioinformatics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pattern Analysis, Statistical Modelling and Computational Learning 2' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

PASCAL2 builds on the FP6 PASCAL Network of Excellence that has created a distributed institute pioneering principled methods of pattern analysis, statistical modeling, and computational learning (see http://www.pascal-network.org/). While retaining some of the structuring elements and mechanisms (such as the semi-annual Themes, and the Pump-Priming and Challenges programmes) of its predecessor NoE, PASCAL2 refocuses the institute towards the emerging challenges created by the ever expanding applications of adaptive systems technology and their central role in the development of artificial cognitive systems of different scales. Learning technology is key to, for instance, making robots more versatile, effective and autonomous, and to endowing machines with advanced interaction capabilities. The PASCAL2 Joint Programme of Activities (JPA) responds to these challenges not only through the research topics it addresses but also by engaging in technology transfer through an Industrial Club to effect rapid deployment of the developed technologies into a wide variety of applications. In addition, its Harvest sub-programme provides opportunities for close collaboration between academic and industry researchers. Other noteworthy outreach activities include curriculum development, brokerage of expertise, public outreach, and liaison with relevant R&D projects. Furthermore, PASCAL2 has adopted an open membership policy allowing for active inclusion in Network activities, of researchers working at non-beneficiary institutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cloud Worlds: from Venus to Exoplanet' (CLOUDWORLDS), addressing dissemination and exploitation.

assistant: **Impact**

Venus is a unique planet in the Solar System with its 100% cloud coverage. We propose to analyze Venus images and spectral observations from the ultraviolet to the near infrared spectral range, to understand the cloud properties and the radiative forcing by clouds in the atmosphere. The techniques we will develop can also be applied to exoplanet observations and modeling. Comparing with the Venus results will help to better understand clouds on exoplanets. We successfully acquired space and ground-based Venus data in 2017-2018 in collaborations with the Japanese Venus orbiter team and 15 other colleagues in Europe, Japan, and USA. Our analysis will use known methods, e.g. the dependence of aerosol scattering on the solar phase angle, a line-by-line radiative transfer model, and a one dimensional radiative-convective model. The proposed research will take place at the Technische Universität Berlin, Germany. Inside the host team, and under the supervision of host Prof. Rauer, the researcher will collaborate with Dr. García Muñoz on the phase angle dependence analysis, with Dr. Helbert to plan scientific observations of Venus with MERTIS at the time of the BepiColombo flyby in 2020, and with Dr. Kitzmann on climate modeling for early Venus. As the host team has strong background in exoplanet research and leads future exoplanet space missions, the researcher will receive training on the comparative analysis of Venus and exoplanets and climate modelling. The proposed study is very timely, considering the upcoming exoplanet missions CHEOPS and PLATO, as well as the proposed future Venus missions. The training and the proposed research will significantly strengthen the career of the researcher, and may help her secure participation in future exoplanet and Venus studies. The re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Augmented Reality Image Synthesis through illumination reconstruction and its integration in interactive and shared mobile AR-systems for E- (motion)-commerce applications' (ARIS) under Fifth Framework.

assistant: **Objectives**

The goal of the ARIS project is to provide new technologies for a seamless integration of virtual objects in an augmented environment, and to develop new visualisation and interaction paradigms for collaborative AR-applications.Two application scenarios will be developed:1) an interactive AR- system, where the end-user can easily integrate 3D product models (e.g. furniture) into a set of images of his real environment, taking consistent illumination of real and virtual objects into account;2) a mobile AR-unit, where 3D product models can be directly visualised on a real site and be discussed with remote participants, including new collaborative and shared technologies.Both approaches will be validated in end-user trials, addressing the new application area of e- (motion)-commerce. In addition to existing e-commerce solutions, e- (motion)-commerce enables the presentation of the products in the context of its future environment.Objectives:ARIS intends to overcome limitations of current AR-solutions to open up new business opportunities by providing:1) easy-to-use methods for 3D reconstruction and camera registration;2) precise camera tracking, using vision methods with AND without markers;3) tools to reconstruct illumination and material data from images (incl. day light);4) seamless integration of virtual and real scenes through consistent illumination between real AND virtual objects in interactive update rates;5) psychophysical evaluation and new tools to adjust the augmented visualisation to the brightness conditions of the real environment for see-through systems;6) new collaboration components, including interaction and communication methods to enable discussion with external users in an augmented environment;7) clear validation of the results through end-user tria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Tracking γδ T cell development and TCRγδ proximal signalling'.

assistant: **Innovation**

T cells are key constituents of our immune system. Two types of T cells are conserved evolutionary and across species: αβ and γδ T cells. While αβ T cells have been intensively studied during the last decades, our knowledge on the development and activation of γδ T cells is still limited. Recently, γδ T cells have become increasingly attractive for immunotherapy of cancer due to efficient killing of tumour cells independently of major histocompatibility complex (MHC) antigen presentation. The proposed project will elucidate how T cell receptor (TCR) signalling is initiated in γδ T cells; and how it contributes to the developmental programming of γδ T cell subsets strongly implicated in cancer immunity.In a pioneer experiment, cellular barcoding and single-cell RNA sequencing will be combined with recent γδ T cell subset markers to gain unprecedented insight into precursor-product and lineage relationships in γδ T cell development; and towards identifying its key molecular determinants. Moreover, TCRγδ signalling will be addressed in thymic subset development at protein and mRNA level by cutting-edge flow-cytometry based techniques. Results of both experimental lines will be integrated to elucidate TCRγδ signalling characteristics and their impact on subset development and functional programming of γδ T cells. The acquired knowledge will enhance our understanding of γδ T cells and allow for their manipulation and fine-tuning in clinical applications.The supervisor’s outstanding expertise in γδ T cells and their role in cancer, in synergy with the researcher’s deep experience in antigen receptor signalling, form the optimal basis for this challenging project. Moreover, the researcher strongly benefits by increasing her research technology and transferable skills in a new,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Homoclinic bifurcation in mechanical systems: theory and application' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The theory of dynamical systems aims to understand the nature of the behaviour of solutions of evolution equations, describing processes in a broad spectrum of scientific disciplines. Dynamical systems that arise in the context of applications often admit additional structure with important consequences for the dynamics. For instance, mechanical systems often possess symmetry and Hamiltonian structure. Many mechanical systems are described by Hamiltonian equations, such as the celebrated Henon-Heiles model of galactic motion, the motion of nonlinear three-dimensional vibrations of strings, localized travelling waves in Hamiltonian lattices (Fermi-Pasta-Ulam chain), vortex dynamics (related to hydrodynamics problems) and non-holonomic dynamics. The main goal of the proposed project is to develop mathematical methods of the bifurcation theory for dynamical systems with special structures. In particular, the focus will be on bifurcations involving homoclinic solutions, which lie  at the basis of the understanding of complicated recurrent dynamics, better known as chaos.  While homoclinic bifurcations have been extensively studied in the context of general systems (without additional structure), the problem of homoclinic bifurcation in Hamiltonian systems has received relatively little attention, despite its obvious relevance for many practical applications. This is mainly due to the fact that homoclinic bifurcations in Hamiltonian systems are often much more challenging than those in general systems.  The project objectives include the study of global bifurcations in systems with different types of homoclinic and heteroclinic orbits leading to a creation of novel methods for the study of Hamiltonian systems with symmetry. An important objective of the proposed project is t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SYSTEM DYNAMICS MODELLING FOR SUICIDE PREVENTION' to be submitted under Horizon 2020.

assistant: **Abstract**

Globally, suicide is the second leading cause of death among young people aged 15-29. Many European countries have seen a sustained increase in youth suicide rates in recent years. Despite the deployment of comprehensive and multilevel suicide prevention strategies, we still do not know which suicide prevention interventions, for which groups of young people, for how long, and with what intensity could generate the most significant reductions in youth suicide rates. Therefore, we cannot efficiently and effectively inform decision-making in youth suicide prevention policy, planning and implementation. Current methodological approaches (meta-analyses, regression models) for synthesizing and operationalising research evidence used to inform suicide prevention strategies have limited adequacy and accuracy because they do not: respond to real-time suicide data; account for the interrelationship, interdependence and nonlinearity of suicide risk factors as they operate across multiple levels (e.g. individual, social); consider the influence of factors such as healthcare constraints (access, capacity). SEYMOUR offers a novel paradigm for guiding the efficient and effective deployment of national and global youth suicide prevention strategies through the use of system dynamics modelling (SDM). SEYMOUR will develop and evaluate a novel SDM that will demonstrate which suicide prevention interventions could generate the most significant reductions in suicide rates among young people aged 12-25. This will include an implementation blueprint to facilitate the transferability, internationalisation and adoption of the SDM as a decision-making tool in youth suicide prevention policy and practice in Europe and globally. The conceptualisation, formulation, testing of the SDM; and, develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'FLUOROCODE: a super-resolution optical map of DNA'.

assistant: **Concept**

There has been an immense investment of time, effort and resources in the development of the technologies that enable DNA sequencing in the past 10 years. Despite the significant advances made, all of the current genomic sequencing technologies suffer from two important shortcomings. Firstly, sample preparation is time-consuming and expensive, and requiring a full day for sample preparation for next-generation sequencing experiments. Secondly, sequence information is delivered in short fragments, which are then assembled into a complete genome. Assembly is time-consuming and often results in a highly fragmented genomic sequence and the loss of important information on large-scale structural variation within the genome.We recently developed a super-resolution DNA mapping technology, which allows us to uniquely study genetic-scale features in genomic length DNA molecules. Labelling the DNA with fluorescent molecules at specific sequences and using high-resolution fluorescence microscopy enabled us to produce a map of a genomic DNA sequence with unparalleled resolution, the so called FLUOROCODE. In this project we aim to extend our methodology to map longer DNA molecules and to include a multi-colour version of the FLUOROCODE that will allow us to read genomic DNA molecules like a barcode and probe DNA methylation status. The sample preparation, DNA labelling and deposition for imaging will be integrated to allow rapid mapping of DNA molecules. At the same time nanopores will be explored as a route to high-throughput DNA mapping.FLUOROCODE will develop technology that aims to complement the information derived from current DNA sequencing platforms. The technology developed by FLUOROCODE will enable DNA mapping at unprecedented speed and for a fraction of the cost of a typi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrated Quantum Sensors' to be submitted under Seventh Framework.

assistant: **Abstract**

The central aim of iSense is to deliver breakthrough enabling technologies and knowledge to push long-anticipated sensor and quantum ICT applications using cold atoms to a broadly accessible and commercially exploitable level.<br/>To achieve this goal, iSense is structured in two highly interlinked and temporally overlapping phases: In the phase 1 iSense will create a science and technology platform introducing novel integrated optics concepts for cold atom production and interrogation. Phase 2 will pursue the establishment of commercial cold atom devices for a wide variety of integrated quantum sensors as well as in information and communication technologies (ICT). Starting with the realization of an integrated high-precision gravity sensor and strong technology dissemination activities this phase will lay the foundations for applications-specific broadening and wide use of the technol-ogy platform beyond the extension of this project.<br/>The long term vision is a modular, scalable and portable quantum technology family based on cold atoms, adaptable to a wide variety of applications in diverse working envi-ronments. Potential applications include fundamental physics tests, quantum ICT devices, satel-lite geodesy, oil / mineral prospecting and communication network timing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Digging out Kinorhynch Roots' under Horizon 2020.

assistant: **Concept**

The Ecdysozoa includes animals with a hard cuticle. Besides the specious Arthropoda and Nematoda, it also nests minor groups like the Kinorhyncha and Priapulida. The Ecdysozoa accommodates more species than all other organism groups in total. Segmentation occurs in two ecdysozoan clades, Kinorhyncha and Arthropoda, and the project addresses the question whether ecdysozoans evolved from a segmented ancestor or if segmentation evolved twice within Ecdysozoa. Understanding ecdysozoan evolution, is understanding the early evolution of a majority of all living organisms. Through immunohistological morphological examinations of muscular and nervous systems in selected kinorhynchs, and Illumina RNAseq-based phylogenetic analyses, I wish to explore if segmentation, as broadly accepted, is a basal trait for all kinorhynchs. The results will allow us to infer if the ancestral kinorhynch was an unsegmented worm. This work has not previously been achievable due to the lack of a reliable kinorhynch phylogeny, and because the hard kinorhynch cuticle has hampered staining of muscular and nervous systems. However, after next generation sequencing techniques have enabled transcriptomic sequencing from even tiny animals, we are now able to produce an improved kinorhynch phylogeny. Furthermore, I have developed methods to overcome cuticular penetration problems, which makes me one of the very few researchers that can successfully carry out immunohistological studies on kinorhynchs. The project “KinoRoot” unites morphological studies with modern molecular sequencing methods, and builds a bridge between these two scientific fields. The expected outcome will not only apply to people with an interest in kinorhynch evolution. It will be relevant for conceptual morphologists working with segmen