RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photon and Neutron Data - Open Data Infrastructure' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The PaN-data collaboration brings together eleven large multidisciplinary Research Infrastructures which operates hundreds of instruments used by over 30,000 scientists each year. They support fields as varied as physics, chemistry, biology, material sciences, energy technology, environmental science, medical technology and cultural heritage. Applications are numerous, for example, crystallography can reveal the structures of viruses and proteins important for the development of new drugs; neutron scattering can identify stresses within engineering components such as turbine blades, and tomography can image microscopic details of the 3D-structure of the brain. Industrial users include the pharmaceutical, petrochemical and microelectronic industries.<br/>PaNdata-ODI will develop, deploy and operate an Open Data Infrastructure across the participating facilities with user and data services which support the tracing of provenance of data, preservation, and scalability through parallel access. It will be instantiated through three virtual laboratories supporting powder diffraction, small angle scattering and tomography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'COmpact MOdelling Network (COMON)' (COMON) under Seventh Framework.

assistant: **Objectives**

The goal of our Network is to address the full development chain of Compact Modeling (CM) of advanced CMOS and III-V technologies, from the technology level to the system level. Our mission is driven by the need to enhance  scientific knowledge, transfer scientific and technological knowledge from academia to industry, to strengthen the European integrated circuit (IC) industry with powerful design automation methodologies and to achieve integration of European research in a fragmented area for the benefit of both young and experienced researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A multidisciplinary Doctoral Industrial School on novel preventive strategies against E. Coli infections'.

assistant: **Objectives**

The doctoral school proposed in DISCo originates from the common interest of Novartis Vaccines (NVD) and the French National Institute of Agronomical Research (INRA) in preventing E. coli infections. Both Institutes have a strong background in microbial pathogenesis, supported by a number of ongoing research programmes aimed at combating human infectious diseases. In particular, NVD, by using a high-throughput in silico genomic approach, named “Reverse Vaccinology”, has recently received approval for the first broad coverage vaccine (Bexsero®) that can help protect all age groups against meningococcal disease. Starting from this successful achievement, we now propose the application of both bioinformatic and experimental approaches (including proteomic, functional and immunological studies) to identify bacterial surface associated determinants able to induce cross-protective antibodies against different E. coli pathotypes. Recently NVD has used a subtractive Reverse Vaccinology approach to identify novel immunogenic antigens capable of inducing protection against extraintestinal pathogenic E. coli species in a mouse model of sepsis. This doctoral program aims to extend such analysis to intestinal E. coli pathotypes for which a broadly protective vaccine would aid in the control of morbidity and mortality associated to diarrheal disease. Therefore, by combining the industrial expertise developed in NVD with the academic research quality of INRA, we propose a strong training programme for young scientists who will have the unique opportunity to learn state-of-the art technologies jointly with the possibility of applying laboratory discoveries to industrial applications. The young fellows’ training path will be complemented by the transferable skills courses, organised by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Public pArticipatory Co-creation Tools for Nature-based Solutions' to be submitted under Horizon Europe.

assistant: **Abstract**

Nature-based solutions (NBS) have gained traction over the past decades as a urban design philosophy that reduces pressures of climate change by creating sustainable and resilient urban spaces. With an investment of over €240 million, EU proves that NBS is “essential component” in its sustainable development strategy. However, the use of blue-green infrastructure, a core component of NBS is often too technical, excluding a primary user and beneficiary, general public, from giving input into NBS planning. This further leads to the lack of public acceptance of NBS projects and poor socially-responsible design. Hence, there is a need for better tools and processes to facilitate co-creation of NBS projects between public and planning professionals. The aim of Public pArticipatory Co-creation Tools for NBS (PACT-NBS) project is to create a framework for facilitation of urban NBS co-design by using public value frameworks integrated within serious games to aid decision making. This will be achieved by: (1) using systematic approach to establish public values metrics relevant to diverse European communities; (2) developing and testing serious gaming tool integrated with environmental and social objectives for urban design; and (3) providing holistic co-creation framework for serious game application in NBS planning, based on the results of public and professionals testing across Europe. PACT-NBS goes beyond the state-of-the-art by addressing critical gaps in NBS public planning, but also captures EU's policy objectives and sustainability agendas through European Green Deal and SDGs 6 and 11. Utilising researchers extensive background on NBS development and social engineering, together with cross-European collaboration and professional networks through hosting institution and n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Precision assembly technologies for mini and micro products (ASSEMBLY NET)' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The Assembly-Net thematic network is focused on technologies for short lifecycle products which require mini and/or micro assembly solutions. It aims to link together key precision assembly technologies, industrial users and providers, and research and academic organisations in order to assist the wider application of innovative precision assembly solutions in Europe. It also aims to enhance the competence and skill levels and solve immediate and future problems affecting both small and large European companies dealing with precision assembly. The network will provide a European wide forum based on formal and informal networking, information exchange, physical and virtual meetings and special interest groupings for strategic planning and information support on introducing the latest technological developments in precision assembly.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterisation and quantification of O6-alkylguanine DNA adducts derived from nitrosated amino acids: Risk factors in colorectal cancer.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The exposure of DNA to alkylating agents can produce base adducts such as O6-alkylguanines, that if not repaired, can lead to a variety of effects including toxicity, mutagenicity and cancer. Although exposure may be significant for certain individuals such as workers in the chemical industry and smokers, all individuals are exposed to alkylating agents from dietary components or that derive from reactive intermediates formed endogenously. For example, nitrosation of dietary amines, amino acids and their derivatives can produce reactive alkylating agents that can result in the formation of a variety of DNA base adducts. One such adduct, O6-carboxymethylguanine (O6-CMG) has been directly correlated to dietary levels of red meat, a known risk factor for developing colorectal cancer, the second most common cancer in Europe. This proposal will use novel synthetic oligodeoxyribonucleotide (ODN) and nucleoside standards to develop highly sensitive mass spectrometry-based analytical methods to identify and quantify levels of specific O6-alkylguanine adducts in DNA. This methodology will enable links to be made between exposure and cancer risk, lead to the identification of novel predictive biomarkers and benefit the assessment of human health at both the individual and population level, paving the way for more informative monitoring studies.


**Keywords:** DNA, DNA damage, O6-alkylguanine, alkylation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'What causes therapy-related malignancies in childhood cancer survivors? Dissecting the etiology of second cancers' under Horizon 2020.

assistant: **Concept**

Therapy-related malignancies are a major cause of long-term mortality among childhood cancer survivors. However, it is unclear how exposure to chemo- and/or radiotherapy early in life induces carcinogenesis. My aim is to determine the mechanisms and rate-limiting steps underlying the genesis of second malignancies in childhood cancer survivors. For this, we will focus on studying the etiology of therapy-related myeloid malignancies (t-MNs). I have pioneered methods to characterize mutation accumulation in single stem cells and study clonal lineages in the human hematopoietic system. My lab is embedded in Europe’s largest childhood cancer center, providing the opportunity to apply our techniques to unique patient material. In Objective 1, we will dissect the life history of t-MN and study its cellular origin. Our key question is: Was the original t-MN clone already present before chemotherapy exposure, or generated as a consequence thereof? We will address this by tracking back clonal lineages in the hematopoietic tissue of patients using the mutations present in their second cancers. In Objective 2, we will study the mutational consequences of chemotherapy in normal hematopoietic cells of children before and after they received treatment. Our key question is: Is enhanced mutagenesis rate limiting for t-MN development? To address this, we will perform in-depth mutational analyses and in vitro validations. In Objective 3, we will determine phenotypic effects of chemotherapy on population dynamics of blood. Our key question is: how does chemotherapy affect selection dynamics and clonal composition of blood? To address this, we will integrate clonal histories and lineage contributions using somatically acquired mutations.  Our unique methodology and anticipated novel insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Microscopic and Algebraic Theory of Nuclei under Extreme Conditions' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project focuses on the theoretical description of low-energy structure of atomic nuclei and the applications to other finite quantum many-body systems. The primary emphasis is on collective excitation and shape phenomena in finite nuclei, and on the structure of exotic nuclei under extreme conditions. Microscopic energy density functionals currently provide an accurate global description of nuclear ground-state properties, while algebraic theories, such as the interacting boson model, are successful in calculating the low-energy structure of medium-heavy and heavy nuclei. To describe spectral properties of nuclei based on a global theory, this project proposes a robust framework constructed by combining algebraic with microscopic theories. This theoretical framework will be used in the study of outstanding open problems in nuclear physics: Microscopic realization of quantum shape phase transition, understanding of the microscopic mechanism behind proton-neutron mixed symmetry, role of pairing correlations in exotic nuclei, the importance of proton-neutron pairing in N~Z nuclei, emergence of symmetries in complex quantum systems, etc. The method will also be used to predict the spectroscopy of exotic nuclei which are extensively studied nowadays at rare-isotope beam facilities around the world, including the planned SPIRAL2 facility in GANIL. The proposed method is general and will be applied to other fields of physics such as the study of analogous excitation modes in molecules or phase structure and low-energy excitations of Bose-Einstein condensates with intrinsic spin. Therefore the project points to giving a comprehensive theory of nuclei under various extreme conditions as well as of general finite quantum systems. In addition, an important component of the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Long-term Stability of VAcuum-encapsulated MEMS Devices using Eutectic Wafer BONDing' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The proposed project aims at the development of improved wafer-to-wafer bonding techniques which allow long-term vacuum encapsulation especially for those micro-electro-mechanical systems (MEMS) requiring high-vacuum cavities to ensure a good performance and to improve the life expectancy and reliability. The vacuum wafer bonding will be optimised using eutecting bonding in combination with getter materials inside the device cavity. Furthermore, a hermetic feed through technology will be developed enabling vertical electrical visa through the cap wafer.In the technology integration and validation phase the new technologies for high-vacuum encapsulation of MEMS devices will be applied to industrial demonstrators:- RF-switch and HF resonator for telecommunication and consumer applications;- Pressure sensor for high-reel avionics and industrial applications.Objectives:As many MEMS devices require a vacuum or controlled atmosphere operation, the main objective of the proposed project is to provide a high-vacuum encapsulation technology for MEMS devices working on wafer-level. The detailed objectives are:- develop a vacuum wafer bonding technology using eutectic bonding in combination with getter materials inside the cavities enabling a stable vacuum (10-4 mbar, 10 years)- develop a getter technology covering materials and processes which is compatible to Si-based MEMS technology;- provide industrial processes and equipment for the vacuum wafer bonding in combination with getters;- develop a vertical feed through technology enabling low stress, high density interconnect performance and excellent RF properties;- develop in-situ measurement techniques for the internal pressure for the high-vacuum and the low-vacuum range, as well as for in-situ moisture detection;- reliable de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modulation of intestinal barrier function and inflammation via butyrate-promoting dietary fibre' (FIBCOLIT), addressing dissemination and exploitation.

assistant: **Impact**

The FIBCOLIT project investigates the impact of fermentable dietary fibres (DFs) on intestinal physiology and inflammation via dietary intervention study in human patients with microscopic colitis (MC), a chronic disease characterised by sustained mild intestinal inflammation. This subject topic has significant interest for public health considering 1) the increased global incidence and prevalence of inflammatory bowel diseases in the last 20 years, and 2) the increased scientific knowledge regarding the role of intestinal inflammation in driving the development of systemic inflammation in metabolic diseases. Currently, considerable knowledge gaps exists regarding the biological and physiological mechanisms that maintain and modulate intestinal homeostasis as well as the pathophysiological mechanisms that lead to chronic intestinal inflammation. The FIBCOLIT project aims to answer these open scientific questions through a multi-omics approach employing several analytical methods to examine DF-induced changes in intestinal barrier function, inflammatory markers, intestinal microbiota composition and functionality, as well as gastrointestinal symptoms, quality of life, and general well-being. The projects utilises a DF known to promote the production of luminal butyrate, a short-chain fatty acid that has been associated with several positive health effects. Overall, the project's methodology allows specific targeting of the mechanistic links between DF intake, butyrate, and intestinal health. Should DF supplementation prove effective at restoring intestinal homeostasis, it could potentially offer a non-pharmaceutical option to the prevention and management of diseases characterised by chronic intestinal inflammation. The project results could potentially also serve as sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Simulation based automated diagnosis, treatment and prognosis of cardiovascular diseases' (CARDITIS) targeting Sixth Framework.

assistant: **Abstract**

The complexity of the cardiovascular system reduces the efficiency of several existing techniques for 3D reconstruction and surgery planning. CARDITIS's objective is to overcome the weaknesses of the existing methods for the accurate reconstruction and simulation of the cardiac system. CARDITIS aims at providing cardiologists and cardio surgeons with a software and hardware platform, which can be used as an intelligent interventional and surgical simulator. Its primary objective is to expand understanding of the human cardiovascular system.From a technological point of view CARDITIS aims at reaching the following objectives: Introduction of a surgery planning system based on the construction of a 3D patient-specific geometric model of the human cardiovascular system; Development of innovative and efficient methods for multi-modal imaging, reconstruction and knowledge representation will be carried out; Providing cardio surgeons and cardiologists with a tool for handling realistic simulations of medical procedures, an interactive virtual environment to graphically design surgical plans, alter the geometry of the 3D individualized model, in order to observe patients' cardiac system and decide about their treatment. Several types of virtual surgeries and interventions will be covered by the system, such as operative angioplasty (e.g. balloon angioplasty) and atherectomy, bypass, stent placement, etc.Finally, CARDITIS will be a valuable tool for health professionals to improve their surgical plans. Hospitals, clinics, cardiological centres and other health units can use CARDITIS for medical care and accurate diagnosis, prognosis and treatment of their patients. It can be used as an advanced educational platform for universities and hospitals. Patients will also greatly bene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Portable measurement systems for atmospheric peroxy radicals' (1998-2002).

assistant: **Innovation**

The primary objective of the proposed project is the development of reliable instrumentation for the continuous measurement of atmospheric proxy radicals by the chemical amplification method. The project proposes to develop ongoing research activities in the area of chemical amplification methodology in order to develop a device enabling online, in-situ, measurement of proxy and oxy radicals in air. This technique has been shown to be practicable under laboratory conditions. However there are still a number of problems with respect to calibration and design of instrumentation tenable portability for direct field measurements. The project will research and develop the sensor for testing by the SME partners, who will then be positioned to utilise and exploit the instrumentation resulting from the project. The primary goal of the project will thus be the provision of a working sensor system together with full calibration facilities in order to prove the technique .