RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Demonstration of soft stimulation treatments of geothermal reservoirs' (DESTRESS) targeting Horizon 2020.

assistant: **Abstract**

DESTRESS is aimed at creating EGS (Enhanced geothermal systems) reservoirs with sufficient permeability, fracture orientation and spacing for economic use of underground heat. The concepts are based on experience in previous projects, on scientific progress and developments in other fields, mainly the oil & gas sector. Recently developed stimulation methods will be adapted to geothermal needs, applied to new geothermal sites and prepared for the market uptake. Understanding of risks in each area (whether technological, in business processes, for particular business cases, or otherwise), risk ownership, and possible risk mitigation will be the scope of specific work packages. The DESTRESS concept takes into account the common and specific issues of different sites, representative for large parts of Europe, and will provide a generally applicable workflow for productivity enhancement measures. The main focus will be on stimulation treatments with minimized environmental hazard (“soft stimulation”), to enhance the reservoir in several geological settings covering granites, sandstones, and other rock types. The business cases will be shown with cost and benefit estimations based on the proven changes of the system performance, and the environmental footprint of treatments and operation of the site will be controlled. In particular, the public debate related to “fracking” will be addressed by applying specific concepts for the mitigation of damaging seismic effects while constructing a productive reservoir and operating a long-term sustainable system.Industrial participation is particularly pronounced in DESTRESS, including large energy suppliers as well as SMEs in the process of developing their sites. The composition of the consortium involving major knowledge institutes a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimizing the delivery and uptake of malaria vaccines in countries with areas of highly seasonal transmission in West and Central Africa' (OPT-MVAC).

assistant: **Innovation**

The availability of effective malaria vaccines is a historic landmark, “a breakthrough for science, child health and malaria control” that “could save tens of thousands of young lives each year” [WHO 2021]. But substantial implementation challenges need to be addressed to realise this potential. In many areas where malaria vaccines will soon be introduced, EPI coverage is suboptimal, especially in the second year of life. Introduction of malaria vaccines is also an opportunity to strengthen delivery of basic vaccines because a) additional immunisation visits will be required to administer 3 doses of malaria vaccine between the ages of 5 and 9 months and a fourth dose at about 2 years, and b) in areas with highly seasonal malaria, annual intensification of vaccine delivery may be advantageous to optimize malaria impact, both providing opportunities for catch-up of other vaccines, and c) recognition of the importance of malaria may lead to be less mistrust of malaria vaccines, as observed during pilot implementations; such positive attitudes could be leveraged to promote vaccination in general. The purpose of this project is to support national immunization and malaria programmes in 14 countries in West and Central Africa with highly seasonal malaria, to optimize delivery and uptake of malaria vaccines, and to exploit the opportunities to strengthen delivery of other vaccines. This will be achieved through a programme of implementation research, adapting delivery approaches to local situations, and sharing information about what works best. The project, which builds on a network of 13 countries that was established through the EDCTP-funded OPT-SMC project, coordinated by the University of Thiès in Senegal, the LIH, TDR, LSHTM, CAPM, MMV and WHO, will provide grants and te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SpectroPhotometric Imaging in Astronomy with Kinetic Inductance Detectors', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The SPIAKID project will build a camera using Kinetic Inductance Detectors (KIDs) to equip an 8 m class telescope to derive ages and metallicities for stars in Ultra Faint Dwarf galaxies (UFDs) in the Local Group. UFDs are the key to understand early galaxy formation processes, including the properties of the first stars, and the role of environment and internal feedback in shaping the evolution of dwarf galaxies. A full exploitation of UFDs to understand these processes requires knowledge of their precise stellar ages and metallicities. This is difficult, in many cases impossible, to obtain with existing instruments because of the faintness of UFDs. SPIAKID will allow unprecedented efficiency in acquiring wide-band spectrophotometry, making this possible. The KID provides a low resolution spectrum (goal: λ/Δλ~15) over a wide spectral range (goal: 0.45 μm to 1.60 μm), a single exposure instead of many single-band exposures. The instrument throughput is increased as the design is simplified since filtering is unnecessary and the visible and infra-red optical paths are combined. The KIDs are read continuously with zero read-out noise so the integration is driven in real time by monitoring the signal-to-noise ratio. Finally, their response is faster (~ 30 μs) than the coherence time of atmospheric turbulence (a few ms) so diffraction-limited resolution is achieved with existing image reconstruction techniques. The reconstructed images will be sharper and deeper than can be achieved by traditional seeing-limited imagers. The SPIAKID instrument will tackle other science cases, e.g. transiting exoplanets and their atmospheres or the electromagnetic emission from gravitational wave sources, and the instrument will be offered to the community to foster other uses. Our technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Manipulation of senescence pathways for cancer therapy: from experimental models to clinic' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal aims to harness a novel type of senescence that we have identified in response to acute Pten inactivation, and which we believe offers a radical therapeutic approach to target the quiescent cancer stem cell in vivo. In characterizing Pten loss Induced Cellular Senescence, which we have named PICS for short, we have discovered that PICS is distinct from other forms of cellular senescence including oncogene-induced senescence (OIS) and replicative senescence. These distinct differences are characterized by a lack of DNA damage and hyper-replication, breaking the current dogma for senescence induction. The ability to induce senescence, an irreversible growth arrest, in cells by targeting Pten signaling, without a requirement for hyper-replication and DNA damage opens up the possibility to target quiescent cells, including stem cells, that have a low proliferative index. This approach has tremendous therapeutic potential and represents one of the most exciting developments for the advancement of prostate cancer therapy in recent years. Through the manipulation of senescence induction pathways we will identify PICS enhancing drugs and redefine the paradigm for cancer therapy. By developing novel mouse models that target prostate stem cells we will evaluate these PICS pro-senescence drugs in a pre-clinical setting.  Finally, these results will be cross referenced with data from human prostate stem cells and we will lay the ground work to translate this to the clinical setting, further developing the clinical potential of these findings to eradicate prostate cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Catch Bond Cross-linked Hydrogels' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Catch bonds are one of Nature’s truly remarkable designs, which exhibit increased adhesive force as tensile force is applied, in contrast to traditional slip bonds whose adhesive force decreases under similar conditions. On reaching a maximum applied force, the catch bond then reverts to traditional slip bond behaviour resulting in a catch-and-roll type action that bacteria and cells use to move in a targeted fashion along a particular surface. The current research project aims to transplant this behaviour from bacterial systems into bio-based synthetic polymer networks, allowing the development of truly biomimetic mechanically adaptable materials. The aims of the project will be achieved by exploring a number of recently identified bacterial catch bonds, isolating the specific amino acid sequence responsible for this behaviour and using them to functionalise bio-based polymer chains. Using the receptor-ligand complexes specific to each bacterial adhesive, dynamic polymer networks will be constructed that display an adaptable response to force as observed in bacterial catch bonds. This represents an important area of research, for whilst the observation of ‘catch’ bond behaviour is relatively recent, their ability to revolutionise biomimetic materials is enormous. Their behaviour under stress is reminiscent of that of smooth muscle during peristaltic motion and materials mimicking this behaviour have the potential to drive new developments in synthetic organ and disease model research. Thoughout this project, fundamental insights will be gained into the intrinsic workings of bacterial catch bonds, specifically environmental factors affecting their behaviour, as well as how their behaviour is modified or scaled by inclusion in a macroscale material. The interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Monitoring Earthquake Mechanics under Evolving Natural TectOnic stress' under Horizon Europe.

assistant: **Concept**

Earthquakes pose a major threat to society, yet short-term forecasting remains elusive due to our limited understanding of how they initiate. Recent advances in seismology and geodesy have significantly enhanced the resolution of observations, revealing the stressed and fractured nature of the earthquake-hosting crust at plate boundaries. However, laboratory rock deformation studies still fall short—focusing on far-from-reality optimal fault orientations in intact elastic crust. MEMENTO—Monitoring Earthquake Mechanics under Evolving Natural TectOnic stress—will bridge this gap by replicating, for the first time, a critically stressed and highly fractured crust during the earthquake preparatory and nucleation phases, under diverse stress regimes, including pioneering experiments on extensional earthquakes.MEMENTO is structured around three main objectives: (1) decoding the role of a critically stressed crust in earthquake mechanics, (2) advancing experimental capabilities for simulating diverse tectonic stress conditions, and (3) integrating laboratory findings with natural seismic sequences using numerical and seismological tools.The project will employ a novel rock deformation prototype, DANTE—Deformation Apparatus simulating Natural Tectonic stress Evolution—to capture the interplay between stress, damage, and slip across the entire earthquake cycle and the full spectrum of tectonic stress regimes. MEMENTO will provide an unprecedented perspective on how diverse stress regimes govern earthquake precursors and nucleation.To ensure the relevance of laboratory findings to natural seismic sequences, MEMENTO will integrate experimental results with state-of-the-art quasi-dynamic simulations and high-resolution seismic observations. This upscaling effort bridges the gap bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Canadian model of the public-private sponsorship for the integration of refugees: the case of Syrians and possible application in EU countries' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Since the Syrian civil war began in March 2011, the United Nations High Commissioner for Refugees estimates that more than 13 million people are in need and an estimated 5.6 million Syrians have fled the country. From this group of Syrian refugees, around one million have requested asylum in different countries of the European Union. While in the EU there is a strong debate concerning the recent refugee crisis and the need to completely reform the current asylum system, in Canada the resettlement and integration of refugees has been a considerable success through the implementation of the Private Sponsorship of Refugees Program which has received much attention from policy-makers in other countries over the past decades. The Overall Objective of this project proposal is a comprehensive analyze of the Canadian private sponsorship model to integrate refugees, of its impact in providing to Syrian refugees a safe and legal way to resettlement and socio-economic integration, and an exploration of its possible modalities of application in some countries of the European Union. The researcher will firstly analyze and present, based on a comprehensive review of government documents, existing academic literature and available data, the overall program, and it will describe its benefits, general results and challenges. Subsequently, the researcher will analyze the private sponsorship program impact in the case of Syrian refugees and will compare the outcomes of this model with the outcomes of other programs such as federal government support and Blended Visa Office-Referred (BVOR) program. Then, the researcher will explore the possible application of the Canadian model in some specific EU countries such as Italy and Germany, identifying and discussing possible benefits and challen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Fundamentals and Applications of Nano-Carbon Electron Emitters'.

assistant: **Objectives**

Development of efficient electron sources is crucial for a wide range of applications including integrated vacuum microelectronics, MEMS, bright flat panel displays, energy conversion devices, and compact microwave amplifiers. In the search for new cathodes capable to produce a strong electron flux at low energy consumption, carbon materials possessing extraordinary field emission properties have been attracted a lot of attention. Control of the morphology and electron properties of nanocarbon species opens tremendous opportunities in the development of advanced electron sources..In the framework of the FANCEE Programme we will combine advanced materials synthesis, state of the art electron microscopy, and a range of characterization techniques to develop fundamentals and applications of the nanocarbon materials for electron emission. The research objectives of the FANCEE are (i) to reveal fundamental mechanisms of the field, thermionic and laser assisted electron emission from the nanostructured carbon materials, (ii) to establish relationship between structural and emission properties and create nanocarbon materials that enable enhanced emission, and (iii) to optimize the material properties and create advanced carbon cathodes for specific applications including cathodoluminescent light sources, X-ray tubes, electron guns for vacuum electronic devices.We anticipate that theoretical and experimental results of FANCEE will provide new insights in the fundamental properties and application potential of nanocarbon materials in electronics. New functionalities arising from the nanostructuring of carbon cathodes will enable development of compact sources of ultra dense electron bunches of ultrashort duration.FANCEE will reinforce the existing and create new cooperation link
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'VErified STAtic analysis platform' (VESTA) under Horizon 2020.

assistant: **Objectives**

Computer software pervades our life but far too much of it contains programming errors (bugs). Software is more and more complex and such errors are unavoidable if programmers are not accompanied with some tools that help auditing software codes. Static analysis is an increasingly popular technique that aims at automatically compute properties of software. These properties then help finding bugs, or proving absence of them. Industrial static analysers are flourishing. Facebook, Google, Microsoft develop their own static analysis tools to help maintaining their huge code base. Critical software industry (aircraft, railways, nuclear, etc.) has embraced the use of advanced static analysis tool as Astrée to companion and sometimes, ligthen their traditional software validation campaigns based on meticulous testing and reviews. Unfortunately, designing advanced static analyses like Astrée requires a very rare expertise in Abstract Interpretation, a foundational landmark in the research area, and implementing these ideas efficiently and correctly is specially tricky.The VESTA project will propose guidance and tool-support to the designers of static analysis, in order to build advanced but reliable static analysis tools. We focus on analyzing low-level softwares written in C, leveraging on the CompCert verified compiler. This compiler toolchain is fully verified in the Coq proof assistant.Verasco is a verified static analyser that I have architected. It analyses C programs and follows many of the advanced abstract interpretation technique developped for Astrée, but it is formally verified. The outcome of the VESTA project will be a platform that help designing other verified advanced abstract interpreters like Verasco, without starting from a white page. We will apply this tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Search for new therapeutic agents against complicated obesity by reprofiling existing drugs'.

assistant: **Innovation**

Obesity is one of the most serious and fast-growing health problem in the European Union, and a leading cause of diabetes. The main barrier for approval of an anti-obesity drug is the safety requirements. We propose to overcome this barrier by discovering phenotypes and biomarkers that identify subsets of patients with safe and efficacious responses to drugs, and by identifying new indications of existing drugs with proven safety profiles. To be approved, anti-obesity drugs need to show a decrease in abdominal fat. We focus on approaches targeting directly abdominal fat cells. In the last years only the cannabinoid CB1 receptor antagonist Rimonabant has been approved as a therapeutic agent to combat complicated obesity. Research performed with this drug has clearly revealed a role for the endogenous cannabinoid system in controlling energy homeostasis. However, its utility is limited to a restricted set of patients.  A new phenotype and/or biomarker may identify responsive patients with good safety profiles. This proposal aims to discover novel or improved treatments in the shortest possible timeframe through three synergistic Specific Aims:  1) Clinical phenotyping of obese patients to identify those that would benefit from existing therapies such as Rimonabant.  2) Discover biomarkers for subsets of obese patients that may correlate with therapeutical outcomes. These biomarkers will be discovered by a novel approach called Combinatorial Cytomic Biomarkers developed by OrphaMed, applied to cells from two physiologically interlinked sources: blood and abdominal-fat samples, extracted from the above phenotyped patients.  3) Identify new indications of existing drugs, alone or in combination, with potential anti-obesity efficacy by lowering the fat content and the glucose