RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Destabilizing vascular colonization to stop meningitis'.

assistant: **Objectives**

Before the antibiotic era chances of survival to bacterial meningitis were minimal. Nevertheless, nearly 100 years later, surprisingly little progress has been made and mortality rates currently remain unacceptably high (10-25%). Supported by clinical and experimental data, the central concept of the Destop project is that bacteria rapidly become insensitive to antibiotics during infection, which leads to treatment failure. We hypothesize that the emergence of such antibiotic insensitivity results from vascular colonization by Neisseria meningitidis i.e. when the bacteria adhere to the surface of the endothelium, proliferate and progressively occlude the vessel lumen. We propose to explore the mechanisms underlying four steps of vascular colonization that potentially alter bacterial sensitivity to antibiotics: (i) bacterial adhesion to the endothelium and auto-aggregation; (ii) colonization dependent changes in bacterial physiology, (iii) bacteria-induced plasma membrane deformation shielding adhering bacteria, and (iv) bacteria-triggered intravascular coagulation.  For this, we will develop a multidisciplinary approach that involves: an in vivo humanized mouse model and innovative microfluidic devices - vessel-on-a-chip model and a bacterial confinement chamber. The Destop project will not only provide novel mechanistic insights in the meningitis pathogenesis process and allow to develop novel strategies to combat bacterial meningitis but also have broader impact by providing a better understanding of how tissues, as a context for infections, reduce the efficiency of treatment of numerous other bacterial pathogens.


**Keywords:** This project is highly multidisciplinary and is related to several fields, immunology, microbiology, structural biology, physiology and biop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sustainable Nuclear Fission Technology Platform' (SNF-TP) targeting Sixth Framework.

assistant: **Abstract**

The long-term contribution of nuclear energy to the mitigation of greenhouse gas emissions could be greatly increased by introducing sustainable nuclear energy technologies.Sustainability means:(i) minimizing the amount, the thermal load, and the toxicity of nuclear waste in geological disposal following the ALARA principle,(ii) efficient use of uranium and thorium resources.The overall objective of the proposed Sustainable Nuclear Fission Technology Platform (SNF-TP) is to develop a coherent European strategy and to provide the mechanisms for consolidating and deciding future joint undertakings within the EURATOM Treaty. The SNF-TP would also consolidate the European and EURATOM positions within the GIF-initiative, including waste management related to closed fuel cycles involving fast neutron reactors. The Platform would not propose to take decisions regarding the EU fission budget, but it would provide the forum for establishing future proposed projects for the EURATOM Framework Program.The SNF-TP has four sub-goals, as follows:A) Establishing a sustainable, closed fuel cycle for electricity production using innovative (Generation IV) fast neutron reactor systems in conjunction with partitioning and transmutation (P and T) technologies;B) Establishing a commercially viable Very High Temperature Reactor (VHTR) for process heat and hydrogen production;C) Improving the performance of currently operating (Generation II) and future near-term (Generation III) Light Water Reactors (LWR) while maintaining a high degree of safety, establishing a unified approach of LWR life time extension, and assessing the SCWR;D) Assuring adequate training to preserve and enhance the human competence in the nuclear field, and maintaining/renewing the infrastructure necessary for achieving s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Technology Diffusion Model'.

assistant: **Concept**

The composition of a future aircraft fleet is, among others, dependent on new available technologies contributing to improved aircraft eco-efficiency. Thus, it is essential to know whether and to which extent new technologies find their way on the aircraft (either as a new configuration or as retrofit). The main objective of the project TeDiMo (“Technology Diffusion Model”) therefore is to establish a sophisticated technology diffusion model in the context of the Technology Evaluator (TE) that facilitates the investigation of the propagation of new technologies developed in Clean Sky 2.  By applying the diffusion model to CS2-technology bricks a more comprehensive response of the contribution of the developed CS2-technologies towards the Flightpath 2050 goals is obtained. At this stage, technologies are assessed in specific concept vehicles which, however, do not cover the whole range of aircraft categories of the operated world fleet. Hence, for the categories not populated with CS2 concept vehicles additional representative aircraft have to be defined. Ecological, economic and social drivers that have a significant influence on the air transportation system must be then identified in order to derive changing requirements and the motivation for developing and installing new technologies into air vehicles. Applying the diffusion model by taking both current technological requirements and the motivation into consideration helps to understand the time-dependent propagation steps of new technologies (within and across the particular aircraft categories) and therefore to assess future aircraft fleet compositions. The project outcome comprises the prediction of future aircraft fleet due to the implementation of new technologies including the demonstration of technological di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Sawing optimisation in concrete, asphalt and alike materials'.

assistant: **Concept**

Overheating in diamond saw blades causes excessive wear and buckling of the saw blade, and the lifetime of the blade would be severely reduced. To prevent this, blades are usually cooled with water but the cooling systems used today are far from optimal. This project is set up to research the heating problem, which is common in sawing concrete, asphalt, stone, and similar materials, as well as the associated cooling system. Once investigated thoroughly, an improved cooling system will be developed and incorporated in a sawing machine, which in particular is suitable for concrete and asphalt floors, to test the renewed concept in practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Presynaptic calcium channels distribution and impact on coupling at the hippocampal mossy fiber synapse' to be submitted under Horizon 2020.

assistant: **Abstract**

This proposal will focus on the hippocampal mossy fiber (MF) synapse, formed between the axons of dentate gyrus granule cells and CA3 pyramidal neurons. The hippocampus plays an important role in learning and memory formation and MF synapses are involved in processing, storage and recall of spatial information. The MF tract connects the entorhinal cortex to CA3 pyramidal neurons. MF presynaptic terminals are large in size, forming giant synapses on proximal dendrites of CA3 pyramidal neurons. Based on this structure, the MF synapse is proposed to have a key role in hippocampal function as a “detonator synapse” that reliably discharges the postsynaptic target neurons. Additionally, it is thought to be involved in storage of information in the CA3 region network by triggering synaptic plasticity between these pyramidal neurons. Despite its important role in hippocampal function and plasticity, there is still very limited information about this key synapse. This proposal will investigate the nanoscale location and distribution of presynaptic voltage-gated calcium channels (VGCCs) at the hippocampal mossy fiber synapse and how it influences coupling at this presynaptic terminal. The opening of VGCCs at presynaptic terminals leads to calcium entry and a subsequent rise in concentration in the vicinity of the channels. The spatial volume occupied by this increased calcium concentration is referred to as calcium domains. The coupling distance between these domains and calcium sensors at the release machinery of docked synaptic vesicles is critical as it determines speed and precision of fusion of vesicles and, thus, release of neurotransmitters. Results from these observations would form the basis for a quantitative understanding of mechanisms underlying time-course of transmi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Society Heading for Awareness in Research Engagement' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Researchers’ Night in Piedmont and Aosta Valley has been for all past editions a regular appointment for the different publics of science. The 2012 edition will be organised on past experiences and activities established in the different venues with important novelties but not only.Indeed, the acronym SHARE could be the flagship for a new venture to be shared throughout Italy and Europe on the basis of the single organisers best practices. Exchanging activities and sharing of goals will strengthen even more the spirit of this important European event.The SHARE process will start in Piedmont and Aosta Valley, where the Partners have identified the best initiatives that will be exchanged between the different locations, and then will be extended to Italy and Europe thanks to a dedicated website.The “Night” in Piedmont will be also an opportunity to actively take part in the “International Year of Sustainable Energy for All” declared by the UN for 2012. Specific initiatives, games, public engagement activities will be organised on this issue. The energy topic will also be a chance to better involve the industrial world and put it in touch with researchers and general public.In terms of activities for the second year will be organised “Pizza with the Prof”, an informal meeting between students and researchers in front of a good pizza. New for 2012 will be the “Coffee corner for science”, short multimedia presentations of researchers followed by discussions with public in front of a coffee or a beer.And then games, experiments, exhibitions, talk-shows, music and much more thanks to the involvement of more than 500 researchers.The European dimension of the event will be provided by the usual participation of the Ispra JRC, CERN and Enterprise Europe Network but will be st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ICT-enabled Wearable Artificial Kidney and Personal Renal Care System' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

NEPHRON+ will provide a major leap forward in Renal Care. It aims at a next generation, integrated solution for personalized treatment and management of chronic diseased, end-stage renal patients. It offers an ideal solution for continuous dialysis outside the hospital offering better blood clearance, while patients can stay mobile and active in social and economic life. It relies on an ICT-enabled wearable artificial kidney for on-body blood purification. This blood treatment can be adjusted to personal parameters and can be remotely controlled by clinical specialists. The system allows for real-time, continuous, multiparametric (tele) monitoring of both the patient and the device via innovative sensors. The continuous data collection allows for early detection of anomalies and trend analysis on the health status of the patient, offering learning curves for improved treatment. Hereby, NEPHRON+ guarantees accuracy of measurements and treatment, personalized feedback and advice and provides a basis for education of patients. The patients benefit from lower costs, higher clearance levels, and more comfort which will result in: a) improvement of their health condition, b) longer life expectancy and c) improved economical and social living conditions. The potential applications of NEPHRON+ solution can be exploited further beyond Renal Care patients, such as those with acute blood poisoning, liver disease, cancer and chemotherapy patients suffering from heart rhythm variations, weight loss and in need of controlled chemotherapy medicine release based on body parameter and fluid measurements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GMES Organisation and Systems Integration Scenarios (GOSIS)' (GOSIS), addressing dissemination and exploitation.

assistant: **Impact**

The overall objectives of GMES are clearly defined in the GMES Action Plan. It is an ambitious initiative to support Europe¿s environmental and security policies, by facilitating and fostering the timely provision of quality data, information and knowledge. The envisaged European capacity to be developed will:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Life course perspectives in studying youth transitions to adulthood: bridging qualitative and quantitative approaches' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The YouthLife project aims to strengthen research on youth transitions from a life course perspective by facilitating multifaceted capacity building at the Centre of Interdisciplinary Life Course Studies (CILCS) at Tallinn University (TLU) through a partnership with three internationally-leading research institutions with complementary methodological expertise and experience: University of Bamberg (UB), University of Southampton (UoS), and the Netherlands Interdisciplinary Demographic Institute (NIDI). YouthLife will create beneficial conditions for TLU to become a first class research institution integrated into leading international networks of life course research with the potential to be a reliable and credible partner for further collaborative research at EU level. The project will increase research, cooperation and networking capacities through peer-to-peer interaction, experience exchange, methodological knowledge transfers and mutual learning during four intensive training courses, six practical workshops, online resources, study and research visits. YouthLife will also improve research management and administration (RMA) skills at TLU and upgrade its RMA support system. The project will tackle the divide between quantitative and qualitative approaches in life course research, introduce methodological innovations and provide new insights into youth transitions to adulthood. The methodological knowledge and experiences gained will be applied to the elaboration of the conceptual and methodological framework of the new Estonian Longitudinal Study of Youth (ELSY) during the project and its implementation afterwards, with the aim of filling the gap in longitudinal data for a better understanding of youth transitions to adulthood.


**Keywords:** Life course research,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable intEgrated care modeLs for multi-morbidity: delivery, FInancing and performancE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over 50 million people in Europe have more than one chronic disease. This number will increase dramatically in the near future. This will increase health care spending to a staggering 20% of GDP. Multi-morbidity becomes the number one threat to population health and economic sustainability of health care systems. New models of care for multi-morbid patients are urgently needed. Given the diversity of Europe’s health and social care systems there is no single model that fits them all.SELFIE aims to improve patient-centred care for patients with multi-morbidity by proposing evidence-based, economically sustainable integrated chronic care (ICC) models that stimulate cooperation across health and social care sectors and are supported by appropriate financing/payment schemes. SELFIE specifically focuses on multi-morbidity, on generating empirical evidence of the impact of ICC and on financing/payment schemes. It is methodologically innovative by applying Multi-Criteria Decision Analysis.SELFIE develops 5 end-results that are adjustable to different care systems in Europe, including CEE:1. A taxonomy of most promising ICC models for patients with multi-morbidity; this taxonomy includes a “toolkit” of interventions that policy makers can use to build an ICC model that best fits into their own health and social care system 2. A detailed list of options for different financing/payment schemes to support the implementation of ICC for multi-morbidity3. A technical document on price-setting of ICC models for patients with multi-morbidity 4. A performance assessment tool to monitor goal achievement; this tool includes new indicators that specifically address the quality of care for patients with multi-morbidity 5. Strategies for implementation and change management Patients, informa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improved energy efficiency in membrane processes - water desalination and purification' under Fourth Framework.

assistant: **Concept**

Project Objectives The objective of the project is to develop methods to improve design and operation of membrane water-treatment facilities, coping successfully with fouling for various feed waters. This will be achieved by the development of advanced feed pretreatment facilities based on the use of an ultrafiltration membrane pretreatment process, the development of improved fouling control techniques based on dosage of anti-scalants and, the development of criteria for selecting optimal pretreatment facilities depending on the types of raw water and membrane. Technical approach A multi-pronged approach will be followed:  laboratory investigation including membrane fouling and scaling, and fouling mitigation measures;  pilot scale tests including ultrafiltration alone and coupled with other membrane processes;  development of standard characterization methods including water and membrane characterization;  economic evaluation of alternatives and formulation of criteria for pretreatment selection including performance studies. Laboratory results will assist the interpretation of pilot-scale data, form the basis for developing standardized raw water tests and contribute towards establishing sound selection criteria for pretreatment processes. Pilot tests are crucial, insuring the best utilization of laboratory results and the development of realistic water testing and process design methods. The successful execution of the previous will lead to the development of generalized process selection criteria. Expected achievements and exploitation It is expected that the results of this project will provide significant economic, environmental and social benefits, including:  development of better feed pretreatment processes leading to energy savings and cost reduction;  enviro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Breathable rigid packages for safe modified atmosphere package for fresh products' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim of this project is to develop a closing of a package that will allow the breathing gases to pass through it but not the microorganisms, to avoid its contamination. The pass of the gases will be through the closing of the lid or through a material like a membrane placed in the sealing area. The gas will pass through the closing at a required flow, depending with the breathing of the food. The package will be fully rigid (tray and lid) so it will be capable to contain all sorts of vegetables and fruits minimally processed (fresh-cut) and it will be stackable. It will be possible to re-close it once opened at consumer's home.