RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Scanning for Emerging Science and Technology Issues'.

assistant: **Innovation**

Today’s societal developments are often influenced by improbable events with high impact. Recent examples are the “cartoon quarrel” and developments impacting energy security. These events are preceded by “weak signals” which are only partially discussed in policy, if at all, and rarely acted upon. The increasing complexity and uncertainty is reflected in the growing demand for tools for anticipatory intelligence, such as scenario analyses, Delphis and modelling and simulation tools. Several countries, Finland, UK and the Netherlands, have initiated horizon scanning projects to identify disruptive events that are not on the RADAR of policy yet. The overall goal of the project is to contribute to the development of an effective system for the early identification of weak signals of emerging issues. For that a weak signals pool, integrating several scanning tools in a wiki to collect and disseminate the information, will be set-up. Additional to its European focus, potential links with national actors and platforms are planned, making use of existing networks such as ForSociety (several of the project members are ForSociety members), to feed the project outputs into European and national policy processes. Beneath this overriding goal is the desire to initiate momentum at national and European level to pro-actively address emerging issues. Next to its practical goals, this project also aims at developing and improving new tools and methods for weak signals of emerging issues to improve detection and the operationalisation of methods using a case oriented approach to contribute to the overall Bluesky call issues. To exploit resources most effectively, this project builds on existing structures and competencies in foresight and horizon scanning in place at national level (ab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inflaming the microenvironment of glioblastoma tumors by ADAR1 inhibition: a two-hit approach for the treatment of brain cancer.' (GlioTarget), addressing dissemination and exploitation.

assistant: **Impact**

The brain is our most precious organ. Not only does it orchestrate vital body functions but it also stores memories and experiences, ultimately defining the core of our human nature. Brain malignancies are particularly disheartening because they disrupt our ability to perform as individuals and hinder our social interactions. Glioblastomas (GBs) represent the most frequent and lethal form of primary brain tumors, with a median survival of 14.6 months and 15,000 newly diagnosed patients per year in Europe and the US. Current therapies invariably fail, likely due to the extreme genetic heterogeneity of GB and the presence of a highly immunosuppressive tumor microenvironment (TME). Here, I propose to exploit an innate immunity checkpoint to simultaneously target cancer cells and their supporting TME. Adenosine Deaminase Acting on RNA 1 (ADAR1) is a central component of the RNA sensing pathway. It edits endogenous self dsRNAs, which would otherwise be recognized as foreign and trigger an aberrant innate immune response. Sensing of foreign nucleic acids results in interferon production which leads to cell-growth arrest, inflammation and immune cell infiltration through the expression of interferon-stimulated genes (ISGs). ADAR1 has recently emerged as a promising immuno-oncology target, with evidence pointing towards ADAR1 loss representing a novel vulnerability of ISG-expressing cancer cells. Despite expressing ISGs, GB tumors have not been evaluated for sensitivity to ADAR1 inhibition to date. I will therefore combine genetic and pharmacologic approaches to inhibit ADAR1 in patient-derived cancer cell lines and pre-clinical mouse models of GB. My aims are: i) to understand the molecular outcomes of ADAR1 inhibition in GB cancer cells; ii) to functionally characterize the T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Diaminations of Alkenes using Metal-free Chemistry' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Organic molecules of all shapes and sizes are required for a multitude of applications eg. in the biomedical, pharmaceutical, and agrochemical industries. Organic synthesis allows an insight into the way in which bonds between atoms can be formed or broken and how molecules can react with each other. Chemists are still faced with the challenge of converting simple, readily available molecules intocomplex structures as rapid, efficient, and cost-effective as possible. Therefore an increase in the efficiency of synthesis will provide enormous benefits to society, quality of life, and a sustainable future.In this context, the use of catalysis to promote chemical reactions will play a vital role. In this research proposal we outline the special properties of iodine-containing molecules. The properties of these compounds are wide spread and we will develop reactions using only catalytic amounts of these reagents. This means that one catalyst molecule will have the potential to create thousands of new molecules with special properties. The addition of small quantities of a catalyst to open up, accelerate, and fully control the outcome of complex chemical processes offers unparalleled opportunities for increasing the efficiency of organic synthesis. The development of these newiodine-containing catalysts and their application in various reactions such as the synthesis of diamines and aminoalcohols in cyclization reactions form the main part of this proposal.We hope to be able to establish concepts that can be also applied in different contexts than initially anticipated and provide positive contributions to organic synthesis and society.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Therapeutic potential of recombinant antibodies to neutralize immunogenic peptides in celiac disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Celiac disease affects about 1% of the population worldwide. It is an autoimmune disease triggered by gluten intake in genetically predisposed individuals. Celiac disease causes intestinal villi atrophy that results in a deficient absorption of nutrients and other risks. Gluten major sources are wheat, rye, barley and some oats. Currently, the only effective treatment is a permanent gluten free diet (GFD). However, a fully GFD is difficult to achieve. The average daily gluten intake in celiac patients is estimated to be 150-400 mg, when 50 mg are enough to damage the intestine of most celiac patients. Accordingly, symptoms persist in 65% of patients, with only 8% reaching complete gut recovery. Preliminary data showed that an antibody raised against the most immunogenic gluten peptide suppressed 90% immunogenicity of hydrolyzed gluten ex vivo. This project proposes a novel therapeutic strategy to alleviate the effect of exposure to gluten for celiac patients not completely responsive to GFD. I aim to assess the potential of anti-Gluten Immunogenic Peptides (GIP) antibodies as therapeutic tools by evaluating their effectiveness to neutralize GIP in vitro and ex vivo. I will develop improved humanized recombinant versions of anti-GIP antibodies, analyze their performance and stability, and optimize their production in mammalian cell cultures in collaboration with partner biotech companies and academia research groups with long experience in the field, bringing novel transferable knowledge to the host institution. The recombinant antibodies will also be explored for their improved performance in diagnostic applications for determining GIP excretion. This Fellowship will allow to extend my existing network beyond Academia towards Biotech Industry and will provide me with si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Acquiring assembly skills by robot learning' under Horizon 2020.

assistant: **Concept**

Present-day industrial robots are made for the purpose of repeating several tasks thousands of times. What themanufacturing industry needs instead is a robot that can do thousands of tasks, a few times. Programming a robot to solvejust one complex motor task has remained a challenging, costly and time-consuming task. In fact, it has become the keybottleneck in industrial robotics. Empowering robots with the ability to autonomously learn such tasks is a promisingapproach, and, in theory, machine learning has promised fully adaptive control algorithms which learn both by observationand trial-and-error. However, to date, learning techniques have yet to fulfil this promise, as only few methods manage toscale into the high-dimensional domains of manipulator robotics, or even the new upcoming trend of collaborative robots.The goal of the AssemblySkills ERC PoC is to validate an autonomous skill learning system that enables industrial robots toacquire and improve a rich set of motor skills. Using structured, modular control architectures is a promising concept to scalerobot learning to more complex real-world tasks. In such a modular control architecture, elemental building blocks – calledmovement primitives, need to be adapted, sequenced or co-activated simultaneously. Within the ERC PoC AssemblySkills,our goal is to group these modules into an industry-scale complete software package that can enable industrial robots tolearn new skills (particularly in assembly tasks). The value proposition of our ERC PoC is a cost-effective, novel machinelearning system that can unlock the potential of manufacturing robots by enabling them to learn to select, adapt andsequence parametrized building blocks such as movement primitives. Our approach is unique in the sense that it canacquire mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Human Lung Microbiota And Innate Immunity' (HUMANITY), addressing dissemination and exploitation.

assistant: **Impact**

Human lung microbiota research is in its infancy, but has already provided compelling evidence that lung bacteria have key roles in human health. However, how lung bacteria interact with the host immune system and influence lung health is poorly understood. I am an infection biologist and immunologist who carried out his PhD on the human pathogen Staphylococcus aureus. I now aim to investigate the cross-talk between resident lung bacteria and the host immune system. I will focus on the lung microbiota of transplant patients, because different bacterial communities have been associated with different immune states in transplanted lungs indicating that microbiota-host interactions are vital for allograft health. My specific objectives are to (i) establish the first culture collection of primary lung bacterial isolates, (ii) characterize their cross-talk with the immune system, and (iii) analyse underlying mechanisms through a combination of bacterial culturing, cell culture and mouse infection experiments, immune system transcriptomics, comparative genome analysis, and metabolomics. This multidisciplinary approach will be conducted with two research groups at University of Lausanne (Prof. P. Engel and Prof. B. Marsland), which provide a unique scientific environment to carry out this project. None of the proposed objectives has previously been addressed. Thus, the project will provide many novel insights relevant for both basic and applied sciences. I will be able to apply my profound knowledge in infection disease and immunology to an emerging field of microbiota research and transfer my expertise to the host groups. In turn, I will expand my scientific breadth by learning advanced concepts of microbial ecology, acquiring methodological skills in community analysis, geno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Supporting Standardisation for Smart Textiles' under Seventh Framework.

assistant: **Concept**

Several European FP6/FP7 smart textiles projects resulted in a variety of high market potential developments. Representative NMP projects are SAFE@SEA–advanced personal protective clothing; POLYTECT–smart textile materials for reinforcing and monitoring infrastructure and DEPHOTEX–flexible photovoltaic textiles. SUSTA-SMART will start from the standardisation needs encountered in these projects, which had each at least one SUSTA-SMART partner involved, as well as those from a carefully selected group of other FP6/FP7 projects. Given the wide range of potential applications, the efforts will be restricted to three focus domains: Personal Protective Equipment (PPE), construction and infrastructure and consumer goods.Although first steps have been taken, the interaction between research and standardisation can still be improved tremendously. SUSTA-SMART opts for a systematic three step approach to forward standardisation:•Mapping both the relevant standardisation actors and the standardisation issues of the FP6/FP7 projects. For the latter, a standardisation strategy audit procedure will be worked out.•Synthesising and prioritising of the needs, based on a broad consensus, leading to a standardisation roadmap.•Compilation of dedicated standardisation input documents (including New Work Item Proposals) and presenting them to relevant standardisation committees. Of special interest will be CEN TC 248 WG31 – Smart textiles, the convenor of which will also serve as the coordinator of SUSTA-SMART. Also liaising with other relevant actors (including in North-American ones) is foreseen.Standardisation is a key issue for further exploitation and commercialisation of smart textiles, especially for PPE and construction as it supports legal provision in those areas. By teaming up wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GPU-WEAR, Ultra-low power heterogeneous Graphics Processing Units for Wearable/IoT devices' (GPU-WEAR).

assistant: **Innovation**

Think Silicon S.A. (TSi) has become one of the only six companies in the world that have a proven capacity to develop Graphics IP technology. This technology is essential for fulfilling the ever increasing demand for wearable and IoT devices. Dealing with the levels of power consumption required by those devices represents a major challenge and TSi has demonstrated and patented novel multi-disciplinary approaches spanning circuits, architecture, compiler and API level optimization techniques. This proposal is about bringing the world’s first ultra-low power optimized heterogeneous multicore embedded graphics processing unit (GPU), low-power software library and associated run-time system to TRL9. The technical advances are to be complemented by a comprehensive innovation management strategy covering IPR protection, commercial exploitation and alliance formation. Central to supporting uptake is the release of platform and tools to the Open Developer Community, in line with best practices in the sector. Support by the SME Instrument would enable TSi to accelerate the disruption of the global market for GPUs through faster and properly executed market introduction. Key benefits to Europe include amplified export revenue (TSi has offices in Silicon Valley and Canada as well as sales representation in Asia), increased employment along with encouragement of private investment in a region significantly affected by the economic crisis (Greece), but most importantly solidifying expertise and IPR in a strategic ICT sector that underpins multiple industries including healthcare, fitness/wellness, infotainment and manufacturing. The IoT market outlook is experiencing high growth with revenues of $32.2B in 2019 with a CAGR of 20% and low power technologies become the key factor bein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced façade and roof elements key to large scale building integration of photovoltaic energy (AFRODITE)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Building integration is the way towards large-scale application of PV within Europe. As aesthetics are key to extensive implementation of PV in buildings, special building elements will be required featuring complex geometrical shapes, improved visual appeal, and transparency. This project aims at the realisation of a diversity of electricity generating construction elements of different shapes at competitive cost in order to address the building market.Successful implementation of the project should allow opening market segments until know reluctant to introduction of PV mainly because of non-technical reasons. There will be an advanced generic cell and interconnection technology developed to realise cost effective production of a variety of custom designed PV elements at competitive and comparable cost. Efforts will be made towards increased awareness of the FV integration opportunities towards the European building society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Increase of the productivity and efficiency of injection processes through the use of metallic foam concepts in the production of moulds (FOINMOULDS)' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The main objective of the FOINMOULDS project is a challenging improvement of quality and performance of metallic and plastic components produced by high pressure die casting, injection and blow molding, in order to meet the increasing demands of customers and end-users. To achieve this, an outstanding weight reduction of moulds, increased efficiency in heat removal and process control is addressed through a new concept of moulds in which metallic foams (cellular materials) are integrated. This totally new a pproach will lead to dramatic improvements in production rates (10% reduction in cycle times for injection and 30% for blow moulding), lower prices and easier handling and maintenance of moulds. In order to meet these strategic objectives, the new concept of moulds will be achieved through the following scientific technological approaches: better mould temperature control, controlled local solidification, avoidance of component distortions, improved feeding and shorter processing time. The project is conce ived in 10 workpackages planned in a logic way. The first 5 containing important work of research and development prior to final design and manufacture of demonstrators. First stages of the project will deal with the conceptual design of moulds and gather ing information to establish a first approach. First thermal and structural analysis will be made to study dimensional stability, stresses in thermomechanicalloads and interactions of mould, metal foam insert and solidifying components. Based on this, a pr oper material selection and final prototype design will be performed. Next step will consists on manufacturing cellular metals at lab scale and testing (feed-back to previous tasks). Once first stages are completed, an assessment of how to integrate metal lic fo