RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Time-resolved diffusive X-ray scattering for the study of cell membrane transport' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In this application we propose to apply the emerging tools of solution-phase, time-resolved X-ray scattering to the study of transfer phenomena in membrane transport proteins. Diffusive X-ray scattering of heavy metals in solution has recently been used by the host to monitor reaction kinetics of simple photochemical systems on a picosecond timescale. We seek to extend the technique to monitor structural dynamics inside the transport channel of halorhodopsin (hR), an important membrane protein that transports halides after photoactivation. The proposed experiment on hR will yield a movie of ion transport in the channel with the aim to clarify into the mechanism of trans-membrane ion transport. Success in the project will open new experimental windows for the study of basic cellular processes of tremendous scientific and biomedical importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Scalable Oblivious Data Analytics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

More and more data is being generated, and analyzing this data drives knowledge and value creation across society. Unlocking this potential requires sharing of (often personal) data between organizations, but this meets unwillingness from data subjects and data controllers alike. Hence, techniques that protect personal information for data access, processing, and analysis are needed. To address this, the SODA project will enable practical privacy-preserving analytics of information from multiple data assets using multi-party computation (MPC) techniques. For this data does not need to be shared, only made available for encrypted processing. The main technological challenge is to make MPC scale to big data, where we will achieve substantial performance improvements. We embed MPC into a comprehensive privacy approach, demonstrated in an ICT-14.b and a healthcare use case.Our first objective is to enable MPC for big data applications by scaling the performance. We follow a use case-driven approach, combining expertise from the domains of MPC and data analytics. Our second objective is to combine these improvements with a multidisciplinary approach towards privacy. By enabling differential privacy in the MPC setting aggregated results will not leak individual personal data. Legal analysis performed in a feedback loop with technical development will ensure improved compliance with EU data privacy regulation.  User studies performed in a feedback loop with our consent control component will make data subjects more confident to have their data processed with our techniques. Our final objective is to validate our approach, by applying our results in a medical demonstrator originating from Philips practice and in a use case arising from the ICT-14.b data experimentation incubato
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Production of Sustainable aircraft grade Kerosene from water and air powered by Renewable Electricity, through the splitting of CO2, syngas formation and Fischer-Tropsch synthesis' (KEROGREEN), addressing dissemination and exploitation.

assistant: **Impact**

KEROGREEN offers a novel conversion route to sustainable aviation fuel synthesised from H2O and CO2 powered by renewable electricity. Because the sustainable kerosene emits less soot and no sulphur, it meets future aviation air pollution standards. The conversion is based on plasma driven CO2 dissociation, solid oxide membranes and Fischer-Tropsch (F-T) synthesis of kerosene. Synergy between plasma activated species and novel perovskite electrodes of the oxygen separator are expected to raise CO productivity and energy efficiency. CO2 emitted upon fuel usage is recirculated as feedstock to the process by direct air capture. The technology is modular, scalable and relies on inexpensive existing infrastructure for storage, transport and distribution. In this project the technology readiness level is raised from TRL 3 to 4 by novel system integration into a container sized unit producing 0.1kg/hr kerosene. Projected cost at this stage of development are estimated at +50% of fossil kerosene. Market entrance will be facilitated by ETS, airline CO2 compensation fund and ICAO regulation. The intermediate CO product is a valuable gas by itself. On-site production offers inherent safety. Safety issues and sustainability of KEROGREEN, including environmental impact, cost and acceptability will be analysed. By dynamically converting surplus renewable electricity in carbon neutral liquid fuel, vast energy storage capacity opens up to the electricity system, providing flexibility and allowing increased penetration of renewable electricity. The KEROGREEN Power-to-X technology is generic as it couples the electricity sector to the oil, gas and chemical sector, with the powerful potential to reduce the overall EU CO2 emission budget, increase energy security and conserve fossil fuel. C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Overcoming the frontiers of biomolecular studies on human history and adaptation using palaeoproteomics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

BACKWARD will address major unsettled debates about African and Asian extinct hominid phylogeny, by developing and deploying a new generation of palaeoproteomic workflows, relying on the most advanced mass spectrometry and bioinformatic solutions currently available.  Ancient DNA (aDNA) sequencing revolutionised our knowledge on evolution, migration and admixture of archaic and anatomically modern humans. However, no hominid aDNA older than ~0.4 million years has been retrieved yet. Ancient proteins instead survive much longer than aDNA, enabling molecular-based phylogeny beyond the limits of aDNA degradation. Recently, mass spectrometry (MS)-based ancient protein sequencing, i.e. palaeoproteomics, convincingly demonstrated its transformative value, enabling molecular-based evolutionary reconstructions for species that went extinct millions of years ago. BACKWARD will use palaeoproteomics to address: (i) the phylogenetic relationships among South African early hominins, and (ii) the hominid palaeobiodiversity in Southeast Asia; two topics debated for generations, and further complicated by recent finds. This knowledge will also provide the evolutionary scaffolding needed to correctly identify and correlate the series of processes that defined human brain expansion and reorganization.  BACKWARD will also screen large sets of morphologically non-informative isolated fossil fragments of bones and teeth, to identify the species and sex of the organism from which they originated. Some of these solutions will be commercially re-purposed to deliver superior performance in public and private analytic laboratories for diagnostics in forensic medicine, and in the food or pharmaceutical industry. As a key BACKWARD feature, the unique contribution provided by each participating ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Impact of Breastfeeding on Children’s Cognitive and Non-cognitive Development: One Step Closer to Addressing the Notion of Causality' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The World Health Organization and the Department of Health and Children in Ireland have put forth recommendations for exclusive breastfeeding during the first six months following birth, and non-exclusive breastfeeding up to two years of age to promote the healthy growth and development of infants. The rates of breastfeeding in the first 48 hours postpartum in Ireland are among the lowest across all European countries and have been reported by the National Perinatal statistics between 36% and 45%. This raises significant concerns as the polyunsaturated fatty acids in addition to docosahexaenoic acid found in breast milk have been argued to be related to children’s cognitive development later in life. However, there is still large debate as to whether breastfeeding is casually related to increased cognitive development and little is known about the relationship between breastfeeding and language and non-cognitive development such as children’s behaviour problems. Causality is a challenging concept to assess without the use of experimental designs yet randomization into breastfeeding versus non-breastfeeding groups raises ethical concerns. The current project utilizes data collected from the Growing Up in Ireland study, comprised of two cohorts of children (over 19,000 participants) from 9-months to 13 years of age using of state-of-the-art statistical techniques (propensity score matching) to better asses the notion of causality. The first aim will assess potential causal pathways of breastfeeding on children's cognitive, language, and behavioural development longitudinally up to 13 years of age. Second, we will compare the effects of this relationship for low-birth weight and normal babies. Third, using generalized additive models which do not impose an assumption of li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a new generation of knee prostheses with enhanced lifespan features using advanced computational biomechanics' (2007-2013).

assistant: **Concept**

Total knee replacement (TKR) is one of the most expensive prosthetic surgery, causing large costs to European countries. In Europe, an average of 107 knee prostheses per 100.000 inhabitants was needed in 2008, generating the need of 335.000 knee prostheses. This number is increasing in European countries, being estimated that the global number will double each year. Considering an average cost of 10.000 euros/surgery in the EuroArea, it is then estimated a global cost of around 3883 M euros per year. In the US the situation is even more dramatic: an average of 500.000 knee prostheses are used each year. Most of knee prostheses are designed and fabricated according to high quality standards and several research groups world-wide are actively working in the subject, mainly in US and Japan. However, knee prostheses are usually affected by several factors, causing their loosening or fracture and then, shortening their long-term lifespan. This project address the enhancement of these designs by analyzing in deep biomechanical factors as fatigue, wear, bone loss of density, etc. Finite Element Analysis (FEA) will be used to study the behavior and performance of existing designs, including nonlinear stress analysis and stress-shielding effect. Comparative analyses will be performed to assess the behavior of different prostheses geometries thus allowing to make relevant changes both in geometry and prosthesis alignment, driven by the stresses gradients around the interface bone-prosthesis. It is well known that small variations in the prosthesis geometry can lead to increment/decrement of wear and thus to a reduction/increase of the prosthesis lifespan. As well, the prosthesis stem geometry is crucial for the coupling boneprosthesis,because the interface stresses can generate b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Specification for a harmonised European Calibration station for Improved Falling Weight Deflectometers measurement of Road Quality' (SPECIFIQ) targeting Fourth Framework.

assistant: **Abstract**

Nowadays several types of Falling Weight quality of roads and airfields by the measurement of the pavement-deflection for the purpose of establishing maintenance requirements. Four problems occur: 1. No calibration of the equipment in regular set-up is possible (only calibration of different components) 2. Different types of FWD-devices result in deviating measurement results 3. Measurement results of different types of FWD's are not exchangeable 4. Deflection bowls measured are also different from those caused by wheel load. In conjunction with the Forum of European National Highway Research Laboratories (FEHRL) and in a later stage with the COST 336 action, international interest was gained for this problem. Nevertheless, no generally accepted solution was found for absolute calibration of a group of FWD's. The proposed (co-operative) research project closely connects to the objectives of Theme I of the SMT Programme. The project will develop and improve the scientific base (finite element analyses of pavement and subbase to establish correlation between FWD-type, wheel load bowl shape, pavement structure geometry and sub-base material characterisation) for written European standards. It should finally result in the development of specifications (including measurement protocols) for the installation of harmonised calibration-stations throughout Europe (and possibly beyond) as well as improved simulation of traffic load by FWD's. Important effect of better measurements will be an improved determination of maintenance-activities needed (higher quality of roads). Every percent performance improvement leads to substantial savings (estimate: 17,5 MECU/year). However reducing user-costs has an even stronger impact as well as indirect effects such as lower frequency of maint
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart Sensor System for Food Safety, Quality Control and Resource Efficiency in the Food Processing Industry' (S3FOOD).

assistant: **Innovation**

Smart Sensor Systems for Food safety, quality control and resource efficiency in the food processing industry (S3FOOD) will facilitate the modernisation and digitalisation of the food processing industry. S3FOOD will stimulate the integration of IoT and related technologies via the implementation of smart sensor systems in the food production processes in order to improve quality control, resource efficiency and the follow-up of food safety in the food production process. S3FOOD brings together clusters with a background in food processing industry, IoT, ICT and sensor technology. It will strengthen current and develop new cross-sectoral industrial value chains within the food production and processing industries through a combination of direct and indirect innovation actions, as well as support and capacity building measures. S3FOOD sets up a network of living labs, organize cross-sectoral, cross-border matchmaking/business/investment events, demonstrations and study visits for SMEs across geographical borders, sectors and with different innovation actors. An innovation voucher scheme will support the realisation of high-TRL, large scale, demonstration and commercialisation projects across Europe. Besides the consortium network, associated clusters from the S3 platform on Smart Sensor Systems 4 agri-food and other networks will support the outreach to SMEs across the EU. More than 2000 SMEs will be reached. More than 200 SME will participate in matchmaking events. A turnover growth rate of 30% is targeted in the SMEs having participated in support cases one year after the end of the project, preserving / creating more than 1000 jobs after the end of the project and by 2025. S3FOOD will operate for 3 years and has a total budget of € 5.046.050,  €3.993.000 of which will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Zee-Zoom-Zap: a new paradigm for cancer theranostics'.

assistant: **Objectives**

We propose a disruptive concept overcoming the fundamental limit of concurrently achieving specific, high-resolution imaging at depth in tissue. Our Zee-Zoom-Zap concept will serve as a one-stop-shop by combining early detection of cancer through small lumens (‘zee’), non-invasive “biopsies” (‘zoom’), and local therapy (‘zap’).The main challenge in realising early detection of cancer is to overcome the fundamental limitation in concurrently achieving specific, high-resolution imaging at the cellular scale at depth in tissue. A radical departure from conventional optical biopsy concepts, our project employs a holistic approach to optical theranostics, with each research pillar constructed as an integral part of a unified concept. Four research fields, represented by four PIs, form its basis: cancer-specific phototheranostic probes, monolithically 3D-printed micro-optical catheters, complementary optical imaging methods for unprecedented range and sensitivity, lasers at wavelengths for both imaging and therapy, and novel physics-enhanced deep learning AI models for imaging, detection, decision support, and treatment guidance.Based on an unmet medical need, the consortium will target pancreatic cancer. For decades, there has been little improvement in detecting and treating this cancer form. The long-term perspective for the Zee-Zoom-Zap is translation into the clinical setting as part of a combined population- and imaging-based screening workflow for early detection of pancreatic cancer and in situ treatment. The concept will be applicable to other cancers reachable through small lumens. The societal and economic impact, in terms of return on investment and increased survival rates, are envisaged to be significant. Furthermore, the project’s innovations, interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NEW DRUGS FOR THE TREATMENT OF PRIMARY HIPEROXALURIA' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Primary hiperoxaluria (PH-1) is a human genetic disease consisting on a deficiency of alanine-glyoxylateaminotransferase (AGT) activity in hepatocytes. This enzyme metabolizes glyoxylate and a lack of its activity leads to an excessive production of oxalate. Oxalate accumulation damages kidney and liver functions at first and other tissues and organs later. This disease is lethal and no effective pharmacological treatment exists nowadays; renal and hepatic transplants become necessary to preserve the life of the patients. Several mutations on AGT gene, leading to protein misfolding that avoids enzymatic activity, have been described as responsible for this disease. Our objective in this project is to develop an effective treatment for PH-1, based in a strategy of pharmacological stabilization of AGT. This novel approach is the state of the art for protein misfolding, and it is based in the use of pharmacological chaperones to recover protein active conformation. In this Memory we include the design, synthesis and biological evaluation of a series of chaperones for AGT. The synthesis has been designed following a Diversity Oriented Synthesis-like scheme, based on the knowledge of the recently described enzyme active site and it is an application of the skills that the applicant acquired during her postdoctoral stay at Cambridge University (UK) as a Marie Curie IEF-Fellow. The project is a multidisciplinary approach with a synthetic chemical part to be developed at the University of Granada, where the applicant is Assistant Lecturer, and a biological part to be developed during short stays at the University of La Laguna (Canary Islands, PH-1 endemic zone) in collaboration with Prof. Eduardo Salido, a specialist in PH-1. The project deals with a topic of interest in Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bacterial single-cell approaches to the relationship between diversity and fucntion in the sea' in the context of a Fifth Framework call.

assistant: **Objectives**

BASICS will identify the most important prokaryotic organisms associated with the carbon and sulphur cycling biogeochemical function of the sea through the development of single-cell analysis techniques applied to pelagic microbes. We will first describe bacterial richness diversity in the coasts of different European seas, describe their role in the biogeochernical cycling of carbon and nitrogen, and develop, fine-tune and tests several single-cell analysis methods that will allow as to identify key bacterial organisms in the function of the marine ecosystem. We will profit from that knowledge to model and study how resilient the link is between the bacterial diversity and the bacterially mediated ecosystem biogeochemical functioning, in the face of the most important global environmental changes expected in European coastal waters.