RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Complexity and Simplicity in Economic Mechanisms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

As more and more economic activity is moving to the Internet, familiar economic mechanisms are being deployed at unprecedented scales of size, speed, and complexity.  In many cases this new complexity becomes the defining feature of the deployed economic mechanism and the quantitative difference becomes a key qualitative one.  A well-studied example of such situations is how the humble single-item auction suddenly becomes a billion-times repeated online ad auction, or even becomes a combinatorial auction with exponentially many possible outcomes.  Similar complexity explosions occur with various markets, with information dissemination, with pricing structures, and with many other economic mechanisms.  The aim of this proposal is to study the role and implications of such complexity and to start developing a coherent economic theory that can handle it.  We aim to identify various measures of complexity that are crucial bottlenecks and study them. Examples of such complexities include the amount of access to data, the length of the description of a mechanism, its communication requirements, the cognitive complexity required from users, and, of course, the associated computational complexity.  On one hand we will attempt finding ways of effectively dealing with complexity when it is needed, and on the other hand, attempt avoiding complexity, when possible, replacing it with ``simple'' alternatives without incurring too large of a loss.


**Keywords:** Games, Auctions, Fairness, Concrete Complexity, Equilibrium, Internet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mechanism-driven neuroprosthetics to restore hemodynamic stability in parkinsonian syndromes' (HemoPARK), addressing dissemination and exploitation.

assistant: **Impact**

About 1 million people with Parkinson’s disease live in the EU, including those with atypical parkinsonian syndromes. Up to 50% of them suffer from severe hypotensive symptoms, which include debilitating episodes of fatigue, nausea, and syncope. These complications are a significant cause of morbidity as they decrease mobility, increase the incidence of falls, reduce quality of life, and increase the risk of stroke. We recently developed a neurosurgical approach that applies epidural electrical stimulation (EES) over the thoracic spinal cord to prevent hypotension in people with spinal cord injury, and also demonstrated proof of concept in one patient with multiple system atrophy. While these results encouraged us to implant a second patient with multiple system atrophy, we found that the effect of EES on orthostatic hypotension was considerably less effective. This observation suggested that improper patient selection could render the therapy ineffective, and that the mechanisms underlying pressor responses induced by EES in parkinsonian syndromes may differ from those in people with spinal cord injury. Here, we will conduct a series of mechanistic experiments in newly developed rodent models of parkinsonian syndromes to understand how EES accesses sympathetic circuits in neurodegenerative states, and how long-term EES impacts these circuits. To address these questions we will deploy a combination of single-cell RNA sequencing, optogenetics, and CRISPR-Cas9 knockouts. Finally, we will leverage the mechanistic insight gained from these experiments to carefully select two participants who will be implanted with EES to treat severe orthostatic hypotension. The proposed work will expose fundamental mechanisms by which neurodegeneration provokes circuit reorganisation, how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dual stimuli-responsive nanoparticles as novel topical drug delivery systems' (STIRENA) under Seventh Framework.

assistant: **Objectives**

This project aims to develop new stimuli-responsive nanoparticles (SRN’s) reacting to changes in temperature and pH, and to evaluate their applications for both topical and transdermal drug delivery. New multifunctional materials, thermoresponsive as well as nanogels and dual pH-Tm responsive materials, using a combination of poly(N-isopropylacrylamide), poly(2-oxazolines) and chitosan will be synthesized and characterized. The main objective of this project will be to develop stimuli responsive nanoparticles based on the new multifunctional materials and evaluate their use as drug delivery nano-systems for skin application. Different techniques such as coprecipitation, oil/water solvent evaporation and high dilution radical polymerization will be used to generate nanoparticle with different physicochemical characteristics. Their clinical potential will be evaluated using preclinical in vitro skin models. The stimuli responsive nanoparticles proposed in this project may be characterized as an innovative approach to the development of new multifunctional skin delivery systems allowing the drug to be released, only when the tissue itself give the appropriate message, in terms of temperature and/or pH response.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Radio Frequency Identification Tags Linked to on Board Micro-Electro-Mechanical Systems in a Wireless, Remote and Intelligent Monitoring and Assessment System for Maintenance of CONstructed Facilities' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Advances in Radio Frequency Identification (RFID) technology, in Micro-Electro-Mechanical Systems (MEMS), in lower-power wireless networking and in computation give hopes for a new generation of tiny, cheap, networked sensors that can be ‘sprayed’ on buildings to provide quantitative information on the structure’s physical state while in service. This can be used to assess the structural condition and aid decision making on retrofit, refurbishment and maintenance so that safety can be attained and material use and costs can be reduced.  The objectives of this work are: 1. To integrate MEMS-based sensors and a RFID tag in a single package of small size that will be attached to concrete buildings to measure acceleration and/or strain that will be transmitted to a remote base station using a wireless interface.  2. To develop a Decision-Support-System (DSS) for proactive remedial measures under operating conditions and rehabilitation after an earthquake damage. 3. To evaluate the system in ‘1’ and the DSS in ‘2’ in a structural laboratory. 4. To field test an integrated package of the system in ‘1’ and the DSS in ‘2’ on an actual building. The proposed system will be used in concrete buildings like schools where information will be sent wirelessly, to a central location (e.g. ministry of education), to be processed. It will result in lower maintenance cost, since problems are cheaper to fix when they first appear, and an increase in safety. The impact on safety will be greater after an earthquake where it is essential to have a quick estimate of the building structural condition. Moreover, it will transform the SME dominated building rehabilitation sector into an advanced knowledge sector, enhance the competitiveness of European SMEs, reduce time to assess the structural c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Materials Modelling Marketplace for Increased Industrial Innovation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The MarketPlace consortium will utilise state of the art information technologies to build an open web-based integrated Materials Modelling and Collaboration platform that acts as one-stop-shop and open Marketplace for providing all determining components that need to be interwoven for successful and accelerated deployment of materials modelling in industry. This includs linking various activities and databases on models, information on simulation tools, communities, expertise exchange, course and training materials, lectures, seminars and tutorials. The proposed MarketPlace will be a central-hub for all materials modelling related activities in Europe and provide tangible tools to connect disparate modelling, translators, and manufacturing communities to provide a vibrant collaboration web-based tool for the advancement of materials modelling in European manufacturing industry. The developed platform will include mechanisms for the integration of interoperable set of advanced materials model workflows for coupling and linking of various discrete (electronic, atomistic, mesoscopic) and continuum models. This will be achieved by developing open and standard post and pre-processing methods that allow complex flow of information from one model to another for both strongly and loosely coupled systems. The Marketplace platform will include access to concerted set of federated databases of materials models, materials data and provide for access to experimental characterisation and stimulate the development of interface wrappers and open simulation platforms. The MarketPlace consortium aims to strengthen the competitiveness and lower the innovation barrier for European industry for product development and process design and optimization using materials modelling.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Research Infrastructures and the Regional Dimension of ERA' (RIC2009).

assistant: **Innovation**

The sixth Conference relating to Research Infrastructures entitled „Research Infrastructures and the Regional Dimension of ERA” will take place in Prague on 24-25 March 2009, under the Czech Presidency of the Council of the EU. It is expected to have this event for around 300 participants. The importance of excellent research infrastructures throughout Europe is being more and more imminent. Nevertheless, it is still important to show these benefits from different angles. There is still a gap existing between the new member states and the rest of Europe in the terms of research infrastructures. The objective of this conference is to motivate policy makers to pay real attention to a strategic approach towards member states policies in the field of research infrastructures, to motivate member states to coordinate their policies and as a main goal, to show the need to develop a European policy and priorities in the field of research infrastructures including the capacities of all member states in a concerted way. The conference should answer, or at least establish discussion on the main issues dealing with the problems of new member states in the field of research infrastructures. This conference wants to exploit the good examples of already existing solutions to the development of research infrastructures throughout Europe. The existence of excellent research infrastructures leads to the competitiveness of those regions. Every research infrastructure is a natural knowledge triangle. In this frame the research infrastructures contribute to the development of human resources in the region, to technology transfer in the region and to the production of knowledge in the region. The first part of the conference has for its aim to establish a proof for this statement. The second
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tracking the temporal and geographic origins of modern domestic horses' to be submitted under Horizon 2020.

assistant: **Abstract**

The goal of the EARLYRIDERS project is to identify the geographic and temporal locus of modern horse domestication. It also focuses on the interplay between domestication and the increase of pathogen load in horses, and the role of epizootic transfer of human pathogens, especially plague. Horse domestication represents a turning point in human history, revolutionizing transport, trade, warfare, agriculture, and allowing humans to form larger, interconnected societies. Despite its importance for human history, this process remains poorly understood. Recent genome sequencing shows that the earliest archaeological remains of domestic horses are not the ancestors of modern domestic horses and that another, still unknown, wave of domestication forged the modern horse during the Early Bronze Age. Horse riding also allowed a rapid spread of diseases. For instance, the plague, that regularly haunted human populations in history, has been already commonly found in human remains dating to the Early Bronze Age. As the gene essential for the transmission through fleas was absent in these ancient strains, the plague might have been transmitted through other, still unknown vectors. This represents a serious gap in understanding of the early epidemiology of this important disease. As the spread of plague appears to be concurrent to horse domestication, the question remains whether the horse accounted for its spread, either as a vector or passively, by contagious riders.  We aim at identifying the source of the second domestication wave and pathogen load in ancient horse populations by sequencing 300+ samples originating from all potential centers of domestication. Full genome sequencing is not possible due to low endogenous DNA content, therefore the samples will be subjected to seque
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy' (T2EVOLVE).

assistant: **Concept**

Immune cells that are empowered by gene-engineering to seek and destroy cancer cells (engineered T cell therapy) constitute a transformative novel treatment that has the potential to cure cancer. Multiple new versions of this therapy are being developed for distinct types of cancer but their introduction into clinical practice is hampered by a lack of standardized and validated models to predict safety and efficacy, customized manufacturing and monitoring to scale up production and clinical use to industry standard, and strategies for optimal patient conditioning. The T2EVOLVE consortium unites scientists and physicians, regulators and policy makers, SMEs, and patient stakeholders to tackle these challenges in an orchestrated multi-disciplinary multi-stakeholder approach. A core feature of this approach will be the embedding of patient stakeholders as contributing members of the team across all levels of the R&D process. The overall aim is the development of an innovation ecosystem that will accelerate the process of developing engineered T cell therapy in the EU. The project will deliver novel tools for education and for improving the communication between healthcare providers and patients, optimized laboratory models that can help determine how safe and effective new therapies with engineered T cells are, standardized methods in which these therapies are produced and monitored during treatment. The consortium members are innovators and pioneers in this field that are dedicated to bringing the EU to the forefront of the global engineered T cell therapy movement. This effort will ensure that EU citizens will continue to have access to the most innovative and best-available medical care, provide guidance on how to implement this novel treatment into the EU health care sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International mobility, local economics and European cooperation policies in the central Sahara' (MOLECOPS).

assistant: **Concept**

Migration by nationals of sub-Saharan countries to the Sahara, often assimilated by African and European public institutions to departures to Europe, have, over the last decade, become the object of increased surveillance. The European Union has put migration at the heart of its relations with Africa, and finances a broad range of programmes that aim at a better management of migration in the Sahara. Ranging from encouragement of legal reforms to assistance in the repatriation of migrants, via equipping border posts with sophisticated means of control, EU interventions in the area take different forms, but they all have in common that little is known of their actual impact and side-effects on the ground. The aim of this research project is to study the nature and practical results of European intervention in migration issues in the central Sahara, and its global cost, by combining an exhaustive analysis of European policies with empirical fieldwork, with a view towards understanding and correcting the representations and assumptions that underpin them. The project will be hosted by the International Migration Institute (IMI) at the University of Oxford. The IMI is a leading research centre with regards to international migration and the legality and legitimacy of international intervention. Training at and collaboration with the IMI would allow the researcher to develop an innovative theoretical framework for future research, leading to a critical turn in his career. Results of the research will be of considerable academic and public interest. Most importantly, it will have important implications for European migration policy, producing reports that should become required reading for everybody involved in these matters. The candidate will do his utmost, during and after
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An integrated research and diagnostic network for skeletal dysplasias' (ESDN).

assistant: **Concept**

Skeletal dysplasias are an extremely complex group of disorders that affect the development of the osseous skeleton. There are over 200 well-characterised phenotypes, which range in severity from mild to severe and lethal forms. Our combined research and demonstration project will establish an integrated research and diagnostic network for skeletal dysplasias [European Skeletal Dysplasia Network (ESDN)]. This multidisciplinary approach will allow us to study comprehensively the molecular genetics and cell- matrix pathology of these diseases. In addition we will demonstrate the viability of molecular diagnosis for skeletal dysplasias by transferring research results into clinical practice. ESDN will improve equity of geographic access to molecular diagnosis for EU citizens and establish laboratory proficiency testing through external quality assessment. Overall, this project will provide new understanding of the pathophysiology of these and more common diseases and allow the development of a service delivery model for the molecular diagnosis of rare genetic diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cbn-grinding of crankshaft in one set-up' (COCOS).

assistant: **Innovation**

Objectives and content The crankshaft is a critical part of every lifting cylinder engine. Its dimensional and form accuracy is not only responsible for the economic life of the whole engine, but it also directly influences the quality of combustion and the exhaust rate of the engine. In the automotive industry, crankshafts are usually a mass product. Numerous variants in smaller batch sizes are used, for example, in truck, marine or other diesel engines. Due to their size and special geometry, crankshafts are one of the most difficult of components to manufacture for any combustion engine. The potential for rationalising the current manufacturing sequence is very high. There are 4 main stages during the machining process on a crankshaft: roughing, heat treatment, finishing and superfinishing. Rough machining is usually done on turn broaching machines, finish machining is done on grinding machines and superfinishing is done on special purpose polishing machines. Particularly with steel crankshafts for high efficiency cars and trucks, thermal treatment takes place in special equipment between roughing and finishing. The principal objective of the CoCoS project (CBN Grinding of Crankshafts in one Set-up) is to drastically reduce this process chain to a single flexible and multifunctional set-up on a single machine, to be demonstrated on the chosen example of crankshafts. Main achievements:  A reduction in the number of production sequences for complex shaped functional parts, by using flexible, outof-roundness grinding, with a 60% reduction in the number of machines and handling systems required.  An improvement in the machining processes through the development of innovative grinding wheels to reduce overall cycle times and costs by 30%.  The development of new non-conta