RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of iron metabolism' (2002-2006).

assistant: **Innovation**

Iron is an essential nutrient, but becomes toxic when present in excess. Iron deficiency leads to anaemia and iron overload is associated with tissue degeneration and organ failure. Body iron indices also affect the course of infectious diseases, such as chronic hepatitis C. Balanced iron homeostasis is critical for health. At the cellular level, iron metabolism is mainly regulated post-transcriptionally by mRNA/protein interactions. Two iron regulatory proteins, IRP1 and IRP2 bind to iron responsive elements (IREs) in the untranslated regions of the mRNAs encoding the transferrin receptor and ferritin, which are involved in iron uptake and storage, respectively, and thereby regulate their expression.   The regulation of systemic iron metabolism is beginning to being understood, following the cloning and molecular characterization of iron transporting molecules and of the hemochromatosis gene HFE, which is mutated in hereditary hemochromatosis, the most common disease of iron overload. A breakthrough in the field was the recent identification of the antimicrobial peptide hepcidin as a humoral factor, which controls dietary iron absorption and iron recycling via the reticuloendothelial system.   The proposed project builds on previous work in the lab and deals with different regulatory aspects of iron metabolism. The specific aims are as follows:  I. To study the mechanisms for iron sensing by IRP1 and IRP2, which are regulated by distinct post-translational pathways.  II. To elucidate the molecular basis of hepcidin function, which, despite of a plethora of genetic data, remains still unclear.  III. To identify molecular links between iron metabolism and the life cycle of hepatitis C virus (HCV).   The implementation of the proposal requires state-of-the art techniques
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The application of advanced computer technology to the new product development process in the ceramics industry' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this proposal is to develop and integrate the different computer based New Product Development (NPD) processes to form a single NPD environment for ceramics at a cost which will not be prohibitive to SME's. Individual companies will then be able to adopt all or part of this computer based NPD environment which they find to be appropriate for their needs. The adoption of these different computer based technologies, when properly integrated, will have the effect of maintaining the competitiveness of the industry in Europe with respect to the rest of the world (including the USA and the Far East); particularly in the high quality sector of the market where variety of good design is especially important. It has been identified through the feasibility study that there is a need to implement advanced computer technology in the ceramics industry. To date most implementation has been through the use of two dimensional Computer Aided Design. The use of these technologies in most industries is further developed and the benefits have been shown in the reduction in time to market. The initial aim ofthe project is to develop software which is designed for the industry. From this development, different manufacturing techniques will be explored to identify the optimal method of implementing advanced computer techniques in the mdustry. The development of a methodology for this implementation is important in order to evaluate these methods amd to demonstrate that there is economic and environmental advantages in using these techniques. CPD(Ceramic Product Development) in conjunction with Staffordshire University and TNO from Holland have brought together a number of companies from Europe who have a common interest in this development. The following areas of work have been ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Individualized early risk assessment for heart diseases' under Seventh Framework.

assistant: **Concept**

Heart failure (HF) is the common end-stage of different medical conditions. It is the only growing cardiovascular disease and its prognosis remains worse than that of many malignancies. The lack of evidence-based treatment for patients with diastolic HF (HFpEF) exemplifies that the current “one for all” therapy has to be advanced by an individualized approach. Inherited cardiomyopathies can serve as paradigmatic examples of different HF pathogenesis. Both gain- and loss-of-function mutations of the same gene cause disease, calling for disease-specific agonism or antagonism of this gene´s function. However, mutations alone do not predict the severity of cardiomyopathies nor therapy, because their impact on cardiac myocyte function is modified by numerous factors, including the genetic context. Today, patient-specific cardiac myocytes can be evaluated by the induced pluripotent stem cell (hiPSC) technology. Yet, unfolding the true potential of this technology requires robust, quantitative, high content assays. Our recently developed method to generate 3D-engineered heart tissue (EHT) from hiPSC provide an automated, high content analysis of heart muscle function and the response to stressors in the dish. The aim of this project is to make the technology a clinically applicable test. Major steps are (i) in depths clinical phenotyping and genotyping of patients with cardiomyopathies or HFpEF, (ii) follow-up of the clinical course, (iii) generation of hiPSC lines (40 patients, 40 healthy controls), and (iv) quantitative assessment of hiPSC-EHT function under basal conditions and in response to pro-arrhythmic or cardio-active drugs and chronic afterload enhancement. The product of this study is an SOP-based assay with standard values for hiPSC-EHT function/stress responses fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rhizosphere priming: Quantifying plant impacts on carbon dioxide emissions from a warming Arctic' (PRIMETIME), addressing dissemination and exploitation.

assistant: **Impact**

Rapid warming is accelerating Arctic carbon cycling, including CO2 release by degradation of thawing soil organic matter and CO2 uptake by better-growing plants. Projections of future Arctic greenhouse gas fluxes retain large uncertainties and do not consider plant-soil interactions that can substantially affect CO2 release - the RHIZOSPHERE PRIMING EFFECT. Theoretical considerations, comparison of ecosystem carbon stocks and model extrapolation of temperate studies suggest a high potential for globally-relevant, priming-induced CO2 emissions from a warming Arctic following shifts in vegetation and rooting patterns. PRIMETIME aims to provide the first observation-based estimate of total plant effects on circum-Arctic soil and ecosystem carbon stocks in a changing climate. Central questions include:(1) How do different vegetation types affect soil and ecosystem carbon stocks and CO2 balance?(2) How do changes in rooting depth interact with depth gradients of soil properties to affect carbon stocks and CO2 fluxes?(3) What is the net effect of expected changes in plant productivity, vegetation distribution and rooting on ecosystem carbon storage across the circum-Arctic?The EXPERIMENTAL MODULE will quantify plant-soil carbon fluxes and plant impacts on soil CO2 release for different vegetation types and soil depths, combining a novel living-plant macrocosm experiment with field observations, cutting-edge 14C-dating (high risk) and 13C-labelling. The MODELLING MODULE will take our recent model to the next level and integrate experimental data to calculate the combined plant effect on ecosystem CO2 sink/source strength in a changing Arctic. The model will be validated against Eddy Covariance-observed CO2 fluxes (high risk). The integrated PRIMETIME approach will break new gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysis of Multiscale Systems Driven by Functionals' in the context of a Seventh Framework call.

assistant: **Objectives**

Many complex phenomena in the sciences are described by nonlinear partial differential equations, the solutions of which exhibit oscillations and concentration effects on multiple temporal or spatial scales. Our aim is to use methods from applied analysis to contribute to the understanding of the interplay of effects on different scales. The central question is to determine those quantities on the microscale which are needed to for the correct description of the macroscopic evolution.We aim to develop a mathematical framework for analyzing and modeling coupled systems with multiple scales.  This will include Hamiltonian dynamics as well as different types of dissipation like gradient flows or rate-independent dynamics.  The choice of models will be guided by specific applications in material modeling (e.g., thermoplasticity, pattern formation, porous media) and optoelectronics (pulse interaction, Maxwell-Bloch systems, semiconductors, quantum mechanics).  The research will address mathematically fundamental issues like existence and stability of solutions but will mainly be devoted to the modeling of multiscale phenomena in evolution systems. We will focus on systems with geometric structures, where the dynamics is driven by functionals. Thus, we can go much beyond the classical theory of homogenization and singular perturbations. The novel features of our approach are- the combination of different dynamical effects in one framework,- the use of geometric and metric structures for coupled partial differential equations,- the exploitation of Gamma-convergence for evolution systems driven by functionals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of Ultra-Sensitive Nanotherapeutic Anticancer Agents for Boron Neutron Capture Therapy' to be submitted under Horizon 2020.

assistant: **Abstract**

One of the major challenges in modern society is the early diagnosis and treatment of diseases. Cancer is one of the most relevant diseases worldwide because of its incidence, prevalence and mortality. Current cancer treatments do not only kill cancer cells but also healthy tissue. In order to overcome this situation, more effective and selective treatments are necessary. Neutron capture therapy (NCT) is a biologically targeted form of radiotherapy which exploits the potential of some specific isotopes to capture thermal neutrons producing charged particles suitable for the treatment of cancer. The range of the particles produced in NCT can be limited to the size of one cell. Therefore, provided that neutron capture species are selectively delivered to tumour cells, no damage will occur to the surrounding healthy tissue. Novel delivery agents suitable for NCT must be investigated that will allow a localised cancer treatment. NANOTER presents an innovative and previouslyunexplored approach to develop ultra-sensitive nanotherapeutic agents for NCT. Neutron capture species will be sealed in the interior of carbon nanocapsules (biocompatible closed-ended carbon nanotubes) and their behaviour against neutron irradiation experiments will be investigated and compared against other current materials for NCT. The interdisciplinary approach taken to develop the proposed research programme is expected to contribute to the development of alternativeand previously unexplored nanoplatforms for NCT, enhancing the performance of current delivery agents for NCT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coupled Cluster Calculations on Large Molecular Systems' (LCC).

assistant: **Innovation**

Quantum mechanics provides the key to the understanding of the molecular world. Many years of theoretical research have made coupled cluster calculations the state-of-the-art method for small molecules, where calculations have reached an accuracy often challenging experimental results. To describe large molecular systems with coupled cluster methods, the computational scaling with the system size of existing methods represents a roadblock to progress. The ultimate goal is to obtain coupled cluster methods that scale linearly with system size and where the calculations are embarrassingly parallel, such that calculations for small and large molecular systems require the same computational wall time. This proposal describes how this goal may be accomplished. The key is to express the coupled cluster wave function in a basis of local Hartree-Fock (HF) orbitals. We have recently shown how such a local HF basis may be obtained and described how linear-scaling, embarrassingly parallel coupled cluster energies may be obtained. Here we present proof-of-concept calculations for the energy and the molecular gradient for the simple model MP2 (second order Møller-Plesset perturbation theory) and propose to use the same technology for higher level coupled cluster methods to yield not only the energy of a large molecule, but also molecular properties as the equilibrium geometry, harmonic frequencies, excitation energies and transition moments, nuclear shieldings, polarizabilities and electronic and vibrational circular dichroism. This proposal will open a new era of accurate quantum calculations on large molecular systems such as nanoparticles and proteins. The presented developments will accelerate research, not only in chemistry and physics, but in molecular science and engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sediment regime disturbance of river catchments in a changing land cover context: Geoenvironmental and population dynamics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In a globally changing world, sediment regime disturbance has emerged as a dominant actor in the modification of river catchments. The sediment regime refers to the sediment budget (amount, type and timing of sediment inputs, outputs and storage) of a river system. Studies of sediment regimes in medium and heavily land cover modified catchments are scarce to the extent that even the likely direction of change of sediment yield compared to background conditions is unknown. Without understanding the changes in the sediments inputs of rivers we are potentially missing half the story. The main and novel research questions within the SEDILAND project are: how (and how rapidly) land cover changes impact on the sediment regime of a river catchment and ultimately on the river channel morphology?; Is there a critical tipping point that guarantees the reversibility of the sediment regime disturbance to a pre-developed scenario?; and if not, how can we assist in fostering a better environmental and territorial management in catchments that preserve natural processes (flow and sediment regime)?. These questions will be tackled thanks to the collaboration between IPE and IHE. These institutions are world authorities on assessing changes on land cover, sediment regime and population dynamics. In turn, the applicant has a broad knowledge in the field of Geoenvironmental Processes. The applicant will be trained in leadership, management, funding, supervision and communication skills. Jointly this team is in a position to push the boundaries of sediment regime disturbance knowledge far ahead, with the ultimate intent to allow the applicant to train through research and become an independent researcher in Europe. This MSCA addresses two of the H2020 Societal Challenges: “Food security, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effects of posttranslational modifications of alpha-synuclein on dopaminergic neurodegeneration in a novel viral vector mediated in vivo model of Parkinson’s disease' (MODIFYPD) targeting Seventh Framework.

assistant: **Abstract**

One of the major pathological hallmarks of Parkinson´s disease (PD) is the progressive loss of specific dopaminergic projection neurons, especially those located in the substantia nigra pars compacta. The neurodegeneration is accompanied by the presence of cytoplasmic inclusions called Lewy bodies, which invariably contain the α-synuclein (α-syn) protein as a major component. Aggregation of α-syn in the brains of PD patients has attracted much attention also because point mutations in the α-syn gene were found to cause rare dominantly inherited form of PD. Although the precise mechanism of the selective vulnerability of dopaminergic neurons in the midbrain remains unknown, there is increasing evidence that multiple pathogenic factors including impaired handling of cytoplasmic dopamine (DA), elevated levels of reactive oxygen species (ROS) and abnormal phosphorylation of α-syn could cause selective death of these cells via the accumulation of soluble neurotoxic α-syn species. Building on the know how and expertise of the host lab I propose to study 1) the pathogenic interaction of DA/α-syn by genetically increasing cytoplasmic DA levels in the viral vector mediated α-syn overexpression model, which I propose would result in a more pronounced neurodegeneration; 2) the role of ROS by upregulation of the enzyme methionine sulfoxide reductase A (known to prevent oxidative damage by scavenging of ROS). I hypothesize that expression of this enzyme should result in protection of dopaminergic neurons in the α-syn overexpression model; and 3) the consequences of increased Ser 129 phosphorylation of α-syn by overexpressed polo like kinases, which should modify neurotoxicity in the viral vector mediated α-syn overexpression model. These 3 approaches could give important clues for u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functions of Matrices: Theory and Computation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Functions of matrices are widely used in science, engineering and the social sciences, due to the succinct and insightful way they allow problems to be formulated and solutions to be expressed. New applications involving matrix functions are regularly being found, ranging from small but difficult problems in medicine to huge, sparse systems arising in the solution of partial differential equations. The objective of this research is to make breakthroughs in theory and algorithms that will have a major impact on applications that employ matrix functions. Productive lines of enquiry and novel methodological approaches have been identified across the spectrum of the subject. In the theory, significant advances on nonprimary functions, structured matrices, and nonnormality will be obtained. New and improved algorithms for evaluating of a variety of functions as well as their Fréchet derivatives and condition numbers will be developed. For the key problem of computing the action of a matrix function on a vector a highly promising, novel approach for the matrix exponential will be developed and applied within exponential integrators. Massively parallel machines will be targeted by developing asynchronous algorithms for matrix functions, which promise a step change in scalability to very large numbers of processors and thereby significant impact on large scale applications in computational science and engineering.This research programme is ground-breaking in going beyond the state of the art across the whole range of matrix functions research from theory to software. The expected impact is high both within the field and in the many applications areas that will benefit from the new and improved algorithms.