RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New directions in bicyclopentane research' (BCPPlus) under Horizon 2020.

assistant: **Objectives**

The pharmaceutical industry is increasingly seeking new tactics for the structural modification of drug candidates to avoid metabolic susceptibility, or to improve pharmacokinetic properties. Analogues called 'bioisosteres', which mimic the dimensions and substituent directionality of problematic structural motifs, but which are not themselves subject to the same pharmacological issues, offer one solution. Often based on scaffolds not found in ‘typical’ drug candidates, bioisosteres can additionally occupy new areas of intellectual property space. Within this growing field, rigid polycycles such as bicyclo[1.1.1]pentane (BCP) are receiving significant attention as arene bioisosteres, as they exhibit similar ring diameters and substituent positioning, and also improve many pharmacokinetic properties relative to the parent arene. Despite the attractive nature of these motifs and current interest, the lack of general routes to complex BCP ring systems means this template is not yet fully accessible to industry. The invention of mild methods for [1.1.1.0]tricyclopentane (TCP) ring opening and functionalization could revolutionize use of BCPs in the pharmaceutical sector. One method not explored to date is an atom transfer radical addition reaction (ATRA) strategy. Using aryl or alkyl halides, ATRA could deliver an abundance of previously inaccessible polysubstituted BCPs from generalized TCP, which would revolutionize this immature, cutting-edge area of organic and medicinal chemistry. This research proposal seeks to: i) explore general and mild ATRA-based syntheses of BCP derivatives, including ring-expanded (hetero)bioisosteres; ii) functionalize BCP products using a range of contemporary processes, including C–H or C–X activation; and iii) apply these methodologies to sy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Provable Scalability for high-dimensional Bayesian Learning'.

assistant: **Concept**

As the scale and complexity of available data increase, developing rigorous understanding of the computational properties of statistical procedures has become a key scientific priority of our century. In line with such priority, this project develops a mathematical theory of computational scalability for Bayesian learning methods, with a focus on extremely popular high-dimensional and hierarchical models.Unlike most recent literature, we will integrate computational and statistical aspects in the analysis of Bayesian learning algorithms, providing novel insight into the interaction between commonly used model structures and fitting algorithms. Key methodological breakthroughs will include a novel connection between computational algorithms for hierarchical models and random walks on the associated graphical models; the use of statistical asymptotics to derive computational scalability statements; and novel understanding of the computational implications of model misspecification and data heterogeneity.We will derive a broad collection of results for popular Bayesian computation algorithms, especially Markov chain Monte Carlo ones, in a variety of modeling frameworks, such as random-effect, shrinkage, hierarchical and nonparametric ones. These are routinely used for various statistical tasks, such as multilevel regression, factor analysis and variable selection in various disciplines ranging from political science to genomics. Our theoretical results will have direct implications on the design of novel and more scalable computational schemes, as well as on the optimization of existing ones. Focus will be given to develop algorithms with provably linear overall cost both in the number of datapoints and unknown parameters. The above contributions will dramatically reduce t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synaptic multi-factor learning rules: from action potentials to behaviour' (MULTIRULES).

assistant: **Concept**

If we are ever to unravel the mysteries of learning, we need a strong theoretical framework that will enable us to trace behavioural properties of memory formation and action learning back to rules for changes of synaptic connections. Experiments on the cell and microcircuit level need hypothesis from theory in order to drive the experimental search for plasticity rules and organize the vast amount of data collected in different labs across Europe and the world. Potential links between synaptic plasticity rules and behavioural outcomes need to be established by mathematical analysis and computer simulation on the systems level, and could ultimately also lead to novel therapeutical approaches.Both theoretical and experimental approaches to synaptic plasticity have been dominated, in the past 30 years, by Hebb¿s rule but the Hebbian framework is a limitation, because it focuses only on two factors: the activity of the presynaptic (sending) neuron and that of the postsynaptic (receiving) one. Hence it neglects additional factors, such as non-specific neuromodulators or global activity states of brain areas. Only very recently a few experiments have appeared that study STDP in the presence of neuromodulators.In this project, I want to break with the preoccupation of Hebbian rules, and formulate and study rules of synaptic plasticity that combine the two Hebbian activity factors with one or multiple global factors. With the new theoretical framework for multi-factor learning rules, to be developed in this project, I will be able to guide the design of novel experiments so that experimental paradigms probe parameters that are relevant for learning. I will be able to make predictions for functional outcomes of learning on the behavioural level, and possibly provide novel strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spectromicroscopy of interfaces - binary metal layers on silicon' in the context of a Fourth Framework call.

assistant: **Objectives**

This research project is based on the application of a novel and emerging technique in surface science - Scanning Photoemission Microscopy (SPEM) - to investigate lateral variations on the submicron scale in the chemical composition and electronic structure of interfaces. It will be performed on the ESCA Microscopy beamline at the ELETTRA synchrotron radiation facility. The research work will focus on the study of binary metal layers on Si surfaces (ex.: Ag+Au/Si(111)), to explore how lateral inhomogeneities in morphology, electronic structure and Schottky barrier height can be affected by interface growth conditions, such as temperature and exposure to gases. This will provide new insight in the field of metal-semiconductor interfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Graphene: Europe in the Lead Coordination and Support Action', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Graphene Flagship (GF) initiative aims at advancing Europe’s strategic autonomy in technologies that rely on graphene and other 2D materials and sustaining the first-mover advantage that Europe has obtained through earlier investments. This overarching goal will be pursued by a number of graphene and 2D materials (2DM) related actions – Research and Innovation Actions (RIAs) and Innovation Actions (IAs) – in collaboration with activities funded by the EU member states and associated countries. The overall coherence of the GF initiative is guaranteed by a Coordination and Support Action (CSA) that allows the separate actions to exploit synergies in their scientific and technological activities and work more efficiently by utilising common services and support functions.GrapheneEU builds upon the extensive experience and expertise of a consortium that has been responsible for the central support and coordination functions of the Graphene Flagship during the FP7 and Horizon 2020 phases and therefore has access to the broad network of researchers and organisations which will participate in the GF initiative. GrapheneEU will ensure a strong and coherent initiative by providing key support functions in coordination and governance, industrialisation, dissemination, and alignment, enabling the participating projects to identify and utilise synergies in their work, share best practices, and promote interactions with relevant national and regional initiatives. GrapheneEU will help secure a sustained European leadership in 2DM by capitalising on the investments in the Graphene Flagship from the FP7 and Horizon 2020 phases and fostering and facilitating the work to be continued during Horizon Europe.


**Keywords:** graphene; 2D materials; coherence; common services; continuati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Computational Thermoelectrics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In the last few years, there is a rapidly increasing interest for seeking out alternative energy solutions due to the environmental impact of global climate change caused by combustion of fossil fuels. One promising way to improve the sustainability of our electricity base is to convert waste heat to electricity with the use of thermoelectric devices.  The proposed project focuses on designing improved energy materials aimed for thermoelectric applications using state-of-the-art computational methods. The emphasis is put on understanding the underlying physical mechanisms for good thermoelectric materials using large scale density functional calculations and molecular dynamics simulations that employ the excellent supercomputing resources available within the Europe. During the previous work the researcher has established his expertise in many areas of magnetism, including spintronics, magnetic multilayers, noncollinear magnetism and in statistical methods using Monte Carlo simulations. From his time as a Marie Cure Fellow, the researcher acquired new tools by broadening his research to new fields including molecular dynamics and phonons. With the proposed project the researcher will be reintegrated in his home country applying his broad knowledge in computational physics to the field of energy materials and in particular thermoelectrics, which is a new field both for the researcher and the home laboratory.The researcher has benefit from his Marie Curie Fellowship by creating an extended network of  contacts and collaborators throughout the European Union and Japan.  He has spent several extended research stays at different research groups for information exchange and collaborations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Next Generation of Cutting Tools Using Additive Manufacturing Technology I, Phase 1' (3DTTool) under Horizon 2020.

assistant: **Objectives**

Our goal is to develop the next generation of thread cutting tools by using additive manufacturing technology (3D printing). Thread cutting tools are used to make screw threads – the main building blocks of modern day machinery. However, these tools have developed very little since they were invented over 100 years ago besides alternating materials used or adding new coatings for the tools to make them stronger. The total Tool Cutting industry worldwide is estimated to be about €17.2 b with average annual growth of about 4% . The bulk of the industry operations are within specific segments: offshore, maritime, automotive and mining – and most of these clients require highly customised tools due to the nature of their business. As such, the Tool Cutting industry spans broadly and innovations that spur new products and ways of working will have far-reaching and important consequences. Printing thread cutting tools in 3D will bring about a high level of innovation to this mature and stagnating industry and will bring about clear and much needed benefits compared to the existing solutions: 1. Improved performance: reduced wear-rate to increase cut rates by 30%-50% 2. Disruptive solution to cooling and lubrication issues: current tools are severely lacking in this aspect 3. Short production lead-time: the new tools reduce production time from 4-14 weeks to 1 week 4. Lightweight product for easy handling: 3D printing enables 60% lighter tools 5. Price competitive offering: expected savings of 10%-30% compared to conventional tools 6. Environmentally friendly product: no waste by-product 7. High-level of client driven customisation: designing in 3D offers full flexibility and adaptation Thürmer 3D Tools project is situated at TRL6 as a technology demonstrated in an industriall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TOPOLOGY OF CONTACT 3-MANIFOLDS' in the context of a Seventh Framework call.

assistant: **Objectives**

THE TOPOLOGY OF CONTACT 3-MANIFOLDS WILL BE INVASTIGATED. THE MAIN TOOLS ARE SURGERY, MORSE THEORY, HANDLE DECOMPOSITIONS, OPEN BOOK DECOMPOSITIONS, FIBERED KNOTS, CONVEXITY,HEEGAARD FLOER THEORY AND OZSVATH-SZABO INVARIANTS. ALSO 4-DIMENSIONAL MANIFOLDS WITH GEOMETRIC STRUCTURES SUCH AS STEIN FILLINGS, SYMPLECTIC FILLINGS AND LEFSCHETZ FIBRATIONS ON THEM WILL BE INVOLVED IN THE INVESTIGATION.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An innovative, effective and minimally-invasive retinal cell therapy combined with a new injection system for treatment of retinal degenerative diseases.' (EIS) under Horizon 2020.

assistant: **Objectives**

Retinal degenerative disease is a debilitating condition with a major impact on daily life. This includes Geographic Atrophy(GA) - as a consequence of age-related macular degeneration (AMD) - and advanced Retinitis Pigmentosa (RP) - all characterized by photoreceptor loss. In fact, they are the main causes of registered blindness. In this regard, there are no currently effective treatments for patients suffering from GA a and RP, leaving approximately 2.6 million people across Europe and over 5 million worldwide with the risk of developing severe visual impairments. Standard techniques to treat GA and DR, including Intravitreal Injections (IVTs) and subretinal transplantation present major problems associated with them.Everads developed a treatment for macular and retinal degeneration, utilizing the innovative Everads Injection System (EIS), a minimally invasive platform for optimal injection of Adult Bone Marrow Mesenchymal Stromal Cells (hBM-MSCs). Unique treatment approach allows simple, office-based safe transplantation of hBM-MSCs in the matrix between the choroidal blood vessels, providing excellent distribution very close to the target organ (retina) and long-term therapeutic effects, targeting multi-billion market opportunity.The Everads treatment is safe, minimally-invasive, can be performed in an office setting and ensures 80% drug distribution in the retinal area, aiming for longer lasting effect of drug. It also reduces the risk of side effects like increased Intra Ocular Pressure (IOP), glaucoma, cataract typical of IVT injections. During the feasibility assessment, a goto market strategy and a supply chain will be established, and further development plan will be drafted. During the phase 2 of innovation project, Everads will perform further product develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Microfluidic microdroplet femtoreactors'.

assistant: **Objectives**

.We aim to develop a technology based on compartmentalising billions of experiments into separate microdroplets in microfluidic devices. These microdroplets, which can have a volume as small as ~5 femtolitres, are separated from other microdroplets by an immiscible phase. Identical microdroplets (<3% polydispersity) can be formed rapidly (at up to 104s-1), allowing ultra-high throughput (109 per day).Furthermore, the microdroplets can be fused, allowing reagents to be mixed in a combinatorial manner, and reactions to be started, stopped or modified at defined times. Splitting microdroplets allows their contents to be aliquoted. If the reactions result in an optical signal, a spatially-resolved optical image of the microfluidic network will allow reaction kinetics to be determined. It will also be possible to separate microdroplets using a microfluidic flow sorter to allow recovery and further analysis or manipulation of the molecules they contain, notably by mass spectrometry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Counterfeiting and Piracy will not affect to our firms in the EU any longer.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Etiqmedia Soluciones Audiovisuales, S.L. is an ICT innovative high-tech startup created in 2016 and emerged from the one of the Spain’s leading engineering centers: Aragon Institute of Technology. We are specialized in developing platforms to process video and audio applying multimedia technology. As an acknowledgement for our business trajectory, we have won the “IDEA Innovative Award 2017"" for “Best Start-up” sponsored by Spanish Government, and we´ve received the Spanish Seal of Innovative Excellence in 2018 (NEOTEC: SNEO-20171032).Counterfeit and pirated trade is a global and dynamic phenomenon that describes a range of illicit activities related to intellectual property rights (IPR) infringement such as: copyright, trademarks, design rights and patents. In 2013, international piracy trade represented up to 2.5% (USD 461 billion) of world trade. This is the equivalent of the GDP of Austria, or the combined GDP of Ireland and the Czech Republic. At this point, ETIQMEDIA has developed the best tool to fight against piracy (Business opportunity).ETIQMEDIA has designed and developed the first digital system able to look for, count and sort the amount of times that images, faces(people), texts and voices appear in any media channel (such as TV, Radio and Internet) at the same time and in real time. Our innovative solution is able to locate who the “pirate” is and where is located in any part of the world, as well as to know what intellectual property right is being violated by the pirate. This solution has been validated in a study pilot.ETIQMEDIA focusses on the cultural and creative market, which is composed by 700,000 cultural-oriented enterprises in EU. Target customers are MEDIA Operators, Public Administrations and Universities.Expected Impact is additional employ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hybrid Quantum Electrical Circuits' (HYBRIDQCIRCUITS) under Seventh Framework.

assistant: **Objectives**

In this project, a variety of promising candidate systems for use as quantum bits (qubits) on future quantum electronic chips will be brought together and investigated in a truly quantum coherent manner.  Static qubits made from superconducting electric circuits, and electrons trapped in islands on semiconductor chips will be coupled to ‘flying’ qubits in the form of quanta of light (photons) and quanta of vibrational motion (phonons) on electronic chips cooled to their lowest quantum mechanical energy state at close to absolute zero.  The research will address key questions of how long the fragile quantum nature of information can last in such systems, how the different systems can be made to interact and exchange quantum information, and how they can be brought together to ultimately form the basic building blocks of future quantum computers, such as quantum logic gates and quantum memories.