RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Control of Cytoplasmic Inheritance in Plants' to be submitted under Horizon Europe.

assistant: **Abstract**

In plants, genetic material is stored in the nucleus and the two cytoplasmic organelles: plastids and mitochondria. While both the nuclear and cytoplasmic genomes are essential for plant survival, the inheritance of these genomes is subject to different sets of rules. Cytoplasmic inheritance differs from nuclear inheritance through two unique phenomena: uniparental inheritance and vegetative segregation. Despite extensive research efforts, the molecular basis of uniparental inheritance and vegetative segregation remain elusive. A major challenge in unraveling the mechanisms is the lack of methodologies. Excitingly, recent advancements in cytoplasmic genome engineering have provided me with a unique opportunity to develop feasible approaches for exploring this crucial area of biology. The ultimate goal of this project is to achieve a comprehensive understanding of cytoplasmic inheritance, which will, in turn, enable us to control the plastid and mitochondrial inheritance. To attain this ambitious goal, we will pursue three specific aims: (1) Identifying the factors that govern maternal inheritance, (2) Promoting the selective transmission of cytoplasmic genomes, and (3) Investigating the molecular basis of vegetative segregation. In this project, we will utilize a combination of genetic and cytological approaches to study cytoplasmic inheritance in the model plants Arabidopsis thaliana and Nicotiana tabacum. The success of our project would represent the first instance of controlled cytoplasmic inheritance in plants. Our fundamental research will provide new tools for testing existing hypotheses regarding cytoplasmic inheritance. From an agricultural standpoint, breeders can leverage this unprecedented capacity to selectively transmit cytoplasmic genomes, thus enabling t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intravascular near-infrared fluorescence and ultrasound coronary imaging', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

NIRFUS will address the documented need of complementing morphology markers with patho-biological information during intravascular imaging. To enable molecular readings and achieve a breakthrough in interventional cardiology, NIRFUS will implement a new ability in medical micro-optics and address critical obstacles in catheter manufacturing and assembly precision. NIRFUS develops novel concepts and abilities in medical micro-optics by exploring advanced approaches for fabricating and aligning optical components, from basic principles to proof of concept and laboratory validation. These novel methods will enable for the first time the development of clinical-grade near-infrared fluorescence (NIRF) readings added to intravascular ultrasound (IVUS), based on hybrid NIRF-IVUS catheters of unprecedented performance and reliability suitable for human use. NIRFUS will further add complimentary sensing modalities to deliver the most quantitative intravascular NIRF performance ever achieved. The advances in precision engineering, and optical integration, NIRFUS will lead to a new standard of medical micro-optics.Likewise, the hybrid NIRF-IVUS catheter will lead to a new standard in interventional imaging and cardiology. NIRFUS may benefit 3 million people who undergo percutaneous coronary intervention (PCI) annually by radically improving treatment and clinical outcomes, as well as the efficiency and cost-effectiveness of the global interventional cardiology healthcare, with estimated cost savings of more than € 3.6 billion.


**Keywords:** optoacoustics, intravascular catheter, microfabrication, interventional cardiology, coronary imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A powerful and efficient tissue regeneration method for reducing the anastomotic leakage rate in gastrointestinal surgery' under Horizon 2020.

assistant: **Concept**

For more than 4 years, Vivostat® together with Rivolution® have been working to develop Obsidian ASG® with the aim to reduce anastomotic leakage in gastrointestinal (GI) surgery. Obsidian ASG® is a best-in-class autologous bioactive fibrin matrix with sustained release of active cells and growth factors providing improved sealing and healing. A preliminary retrospective, single-arm study with 261 patients from two participating colorectal units in Austria, indicate that application of Obsidian ASG® at anastomotic site following colorectal resection is safe and associated with a low rate of anastomotic leakage of 2.3% (1). Obsidian ASG® may therefore reduce leakage by more than 50% in gastrointestinal resections. Gastrointestinal resections often results in anastomotic leakages: • In Europe more than 450.000 new cases of colorectal cancer every year - most of these will undergo anastomosis surgery • In up to 19% of gastrointestinal surgeries the resection results in anastomotic leakage making it one of the most dreaded complication following GI surgery  • The cost per patient experiencing anastomotic leakage is up to 4 times higher compared to an uncomplicated procedureThe EIC Accelerator funding allows Vivostat® to conduct a large-scale multicenter clinical trial across the EU (up to15 hospitals in 7 countries) with inclusion of approximately 440 patients. The main objective of the study is to investigate whether the application of Obsidian ASG® during colorectal resection reduce the rate of postoperative anastomotic insufficiency compared to standard anastomotic technique. Market access and reimbursement strategy with focus on Germany, marketing strategy with product launch plans as wells market expansion plans are also key elements in the project. These activities wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational design, fabrication and engineering methods for unconstrained, highly resource efficient, point-supported timber slabs in multi-storey buildings' in the context of a Horizon Europe call.

assistant: **Objectives**

The project aims to develop novel design, engineering and fabrication methods for point-supported timber slab structures in multi-storey buildings. It aims to provide the fundamental technologies for a sustainable alternative building system that could broadly replace point-supported reinforced concrete slabs - especialy in urban building projects. The project aims to develop a universally applicable, suppliable, usable and affordable alternative building system and make timber construction broadly available. It is based on a building system concept, in which complex arrangement of wood lamellas provide the potential for high structural performance. Questions of design computation, structural engineering, simulation methods and mechanical testing of this system will be addressed in the project. Provided the complexity of the material makeup and potentially long computing times, surrogate modelling methods will be developed based on disciplinary modelling methods. These allow fast computation of various design options. An AI-based Intelligent Decision Support System will integrate all surrogate models and provide informative design feedback of the universal timber slab system throughout all design stages. The building system will be applicable to multidirectional, long-span slabs and enable computationally derived geometric adaptivity to typical building project boundary conditions - such as site, program and design intent. The possibility for free and sparse column layouts allows for higher design flexibility and the design of mixed-use urban platforms with a great potential for long-term reusability. The system leverages computational design and construction to build bespoke, highly material efficient and digitally scaleable building structures from wood. Hence it prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RNA-based technologies for single-cell metabolite analysis'.

assistant: **Objectives**

Metabolism is the foundation of all living organisms. While cells in a population are often phenotypically different, most of our current analytical approaches still probe metabolism only at the population level. Because strong evidence exists that metabolic cell-to-cell heterogeneity has, for instance, disease relevance, researcher from MetaRNA will overcome this severe analytical limitation through exploiting exciting opportunities emerging from the RNA field. Such synergy potential between the metabolism and RNA research fields has until today not been exploited, because they are separated from each other in Europe and worldwide. Through consequently missing research training programs we thus lack experts with combined knowledge in metabolism and RNA. The aim of the MetaRNA proposal is therefore to establish a European Training Network (ETN) that educates specialists for academia and industry - fully trained at the interface of these two fields - in the development and application of RNA-based sensors to investigate metabolism at the single-cell level, to apply these tools for novel biotechnological applications and to provide a framework for their future use in diagnostics and therapeutics. In MetaRNA, eight research groups from the metabolic and RNA fields and six partners from the private sector join forces to create a platform of mobility and training to 15 early-stage researchers (ESRs), by means of customized research projects, exchange of knowhow among researchers and partners, attendance to specialized courses, workshops and conferences, as well as training in complementary skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Designing Novel Efficient Catalytic Strategies for the Transformation of Lignocellulose into Lignin-derived Chemicals and Valorisable Carbohydrates' (CATLIGCAR) under Horizon 2020.

assistant: **Objectives**

The utilization of renewable lignocellulose biomass (composed of cellulose, hemicellulose and lignin) alternative to fossil fuels is crucial for long-term economic and social stability. In this context, the catalytic reductive lignocellulose fractionation (CRLF) process has received tremendous research interest as this strategy enables one-pot conversion of lignocellulose into useful lignin-derived chemicals, while retaining a solid (hemi)cellulose fraction that can be used for the production of fuels, chemicals or paper. The development of promising heterogeneous catalysts having abundant redox and acid properties, along with the application of a proper solvent is a great challenge for efficient CRLF process. Nanoscale palladium-nickel (Pd-Ni) and ruthenium-nickel (Ru-Ni) particles dispersed on shape-controlled zinc oxide (ZnO) are considered to be a unique class of heterogeneous catalysts due to the size- and shape-tuned catalytic properties. The integration of Ni with Pd and Ru can provide new, enriched, selective redox sites and simultaneously minimizing the use of noble metals. As well, controlling the shape of ZnO particles allows a selective exposure of reactive crystal planes, resulting in enhanced Lewis acidic strength. Thus, the synergistic interactions of Pd-Ni and Ru-Ni nanoparticles with the shape-controlled ZnO will provide superior redox and acid properties that can show a promising effect in CRLF process. Therefore, this project aims to develop a family of novel multifunctional M-Ni/ZnO (M = Pd, Ru) catalysts by varying the ZnO shape (spheres, rods and polyhedra). A range of analytical techniques will be used to understand the catalysts’ properties and aid catalyst design. The efficiency of developed catalysts will be tested for one-pot CRLF process usin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hyperbolic Components and Wandering Domains in Complex Dynamics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Complex dynamics is a subfield of dynamical systems, where the systems in question are generated by the iteration of a holomorphic function on a complex manifold. This proposal concerns itself with the following question:What is the equivalent of a hyperbolic component for parameter families of entire functions with wandering domains?Both hyperbolicity and wandering domains are the subject of much research in the area, and lie at the core of some of the field's major open questions. This project attempts to link them by focusing on three separate objectives:- Investigating generalisations to wandering domains of the multiplier map, a central tool in understanding hyperbolic components for parameter families of rational functions.- Fully classifying the structure of the Teichmüller spaces associated to wandering domains of entire functions.- Obtaining quasiconformal invariants for the boundary dynamics of wandering domains.


**Keywords:** Dynamical systems, complex dynamics, wandering domains, hyperbolic geometry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Assessing functional connectivity patterns within and among human visual cortical areas associated with contextual influences on visual perception' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Neurophysiological studies in the second half of last century using simple isolated stimuli have provided invaluable groundwork to understand aspects of human visual system, and led to the classical feed-forward model of vision. In the classical model the information processing occurs in a hierarchical manner in the visual system and the direction of information flow is more or less unidirectional. However a recurring theme in recent research is that it is not always possible to predict behavioral or neural responses to stimuli embedded in real-world context based on previous measurements made to isolated stimuli. These recent studies have demonstrated that the flow of information could be much more multi-directional than the classical model has predicted. In the studies proposed here, using behavioral and functional magnetic resonance imaging (fMRI) techniques, functional connectivity patterns within and among visual cortical areas that give rise to the contextual influences on visual perception will be investigated.Cognitive neuroscience studies biological mechanisms that underlie cognitive functions, in other words, the connection between the brain and mind. A detailed understanding of the brain and mind will have a dramatic impact on all aspects of human life, from health to social wealth and to national security. Vision constitutes a particularly attractive model for cognitive neuroscience research because the input to the system can be measured precisely in physical units, such as the luminance of a surface in candelas per meter square. Furthermore, the sub processes of a visual function can be identified relatively easily. Both of these properties make well controlled experimentation possible. The findings of this project will make a significant contribution to o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GROWTH' (GROWTH), addressing dissemination and exploitation.

assistant: **Impact**

The long-term objective of the GROWTH project is to significantly contribute to business-academia mobility-collaborations and career development of more highly qualified future leaders with innovation skills in applied and needs-driven research at universities and colleges, SMEs, excellence centres (CoE), research institutes and large industry.VINNOVA will allocate resources for the period 2012-2017 which, in conjunction with co-financing, will result in a powerful investment comprising a total contribution exceeding € 35 million. With this programme, Mobility for Growth, VINNOVA will promote qualification and career development for people running needs-driven research within all scientific fields and which is being conducted in collaboration between academia, industry and/or the public sector. The proposed GROWTH project will add substantially to the international part and profile including its funding structure for incoming, trans-national mobility and outgoing transnational mobility with a reintegration phase of experienced researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanistic studies of metal-dependent DNA cleavage in Type II topoisomerase toward the rational design of novel anticancer drugs' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Type II topoisomerase (TopoII) metalloenzymes are crucial in regulating DNA topology in replication, transcription, recombination, and repair processes. TopoII is thus a validated target for clinical antibiotics and anticancer drugs. Recent high-resolution X-ray structures of the TopoII/DNA complex showed multiple metal ions bound to the TopoII active site. On the basis of these novel findings, a unified two-metal-ion reaction mechanism for TopoII catalysis has been proposed. However, it is still not clear how this Mg-aided two-metal-ion mechanism permits TopoII to cleave and relegate back DNA strands. Building on our previous studies on metalloenzymes, we seek here to clarify TopoII’s two-metal-aided enzymatic mechanism and identify novel TopoII inhibitors, thus completing the proposer’s computational skill set, boosting her chances of establishing and leading soon an independent computational group. We propose two objectives: First, we will depict the reaction path connecting the enzymatic reactants and products in TopoII. We will achieve this using state-of-the-art computational methodologies such as molecular dynamics (MD) and hybrid quantum mechanics/molecular mechanics (QM/MM) simulations coupled to enhanced sampling techniques for free-energy estimates. We will thus elucidate the metal ion dynamics in TopoII catalysis, together with the metal-induced structural changes that affect the reactivity and efficiency of TopoII catalysis. Importantly, we will investigate TopoII catalysis in the presence of either the catalytic Mg or inhibitory Zn ions in the catalytic pocket. Secondly, we will integrate mechanistic insights on TopoII catalysis with the recent structural and biophysical data on TopoII to decipher drug resistance and identify new TopoII inhibitors. To this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Future of European Independent Art Spaces in a Period of Socially Engaged Art'.

assistant: **Concept**

FEINART is an extensive collaboration between degree-awarding research-centres in political philosophy, art theory/practiceand curatorial studies/cultural management, and the independent European art sector, as the basis for the firstinterdisciplinary and holistic investigation of the democratic role and function of socially engaged art in Europe. In this it willtrain 11 Early-Stage Researchers in order to provide the relevant academic and non-academic skills to engage with thechallenges of this new artistic and cultural landscape. The 11 ESRs will be spread across four academic Beneficiaries(University of Wolverhampton University of Iceland, University of Edinburgh, Zeppelin University, Germany) and 7 PartnerOrganizations (Tensta Konstall, Sweden; BAK, Netherlands; State of Concept, Greece; W-Est, Italy; Tranzit.ro, Romania;Teatr Scena Prezentacje (Biennale Warsawa), Poland; and Icelandic Academy of the Arts, Iceland). The selected POs represent an exemplary cross section of small-scale and larger independent spaces - projects spaces, cultural centres, art labs/research hubs -working under different demands and expectations, yet all providing invaluable support and resources for artists working inthe area of socially engaged practice. The training programme, as such, will provide invaluable data about the distribution,impact, and role of socially engaged art, as a future contribution to funding policy recommendations on state support of artbeyond the museum’s traditional functions, and debates on art and public culture.


**Keywords:** art theory and practice, curatorial studies, art and political philosophy, socially engaged art,democratic participation, art and the public domain