RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Local temperature jumps for single Protein Molecules: a route to study dynamics from Microseconds to hours' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

We propose to physically trap a single bio-molecule into successive conformational sub-states by rapidly freezing and thawing it with its immediate surroundings. After many successive freeze-thaw cycles, we will reconstruct the dynamics of the same single molecule from the series of frozen snapshots, probed by the fluorescence of optical labels. Fast cooling and heating will be achieved by maintaining the molecule in a focused laser spot within a cold cryostat. We will control the local temperature by modulating the power of the heating beam. The time response, given by heat diffusion out of the diffraction limited hot spot is as short as a few microseconds. In the past several years unique know-how and infrastructure have been developed and feasibility of quick freeze-thawing cycles has been demonstrated in Huygens Laboratory, Leiden University. In the coming years, we want to extend the measurements first to oligopeptides and small proteins, then to larger proteins in physiological conditions. We expect this project to open a completely new window on protein dynamics, by enabling us to observe the same single molecule over large time intervals, at high-time resolution. The series of snapshots will give information on relaxation processes down to microsecond timescales, inaccessible to other single-molecule methods, and make it possible to map out the topography of the energy landscape, i.e., not only the accessible conformational sub-states, but also the favored pathways connecting them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Demystifying the impact of HIV-antiretroviral therapy on fertility and the epigenome of gametes and early embryos'.

assistant: **Innovation**

HIV (Human immunodeficiency virus) is a global epidemic that led to the death of over 40.1 million persons since its first report. Currently, about 38.4 million people are living with HIV (PLHV) globally; 1.9 million in Nigeria. The introduction of combination antiretroviral therapy (cART) has improved the lifespan of PLHV making it a chronic disease, yet in 2021 about 650,000 persons died from HIV-related illnesses. Efforts are being made to scale up treatment access to cART to reduce mortality. However, in recent years, a not well-understood decline in fertility of PLHV undergoing cART is a great concern for HIV treatment. Recent studies detected epigenetic abnormalities in the blood of PLHV undergoing cART with global changes in DNA methylation, where it is unclear if cART or HIV itself could be the cause. Abnormal establishment of DNA methylation in the gametes can lead to the manifestation of epimutations in the growing embryo with potentially bad consequences like embryo loss, diseases, and cancerogenesis. This study aims to determine the impact of cART on fertility and on the DNA methylome in gametes and derived embryos in the mouse as a model system. It will involve the analysis of DNA methylation changes in spermatozoa and oocytes, derived embryos, and offspring, as well as the examination of embryonic genome activation in 2-cell embryos and successful blastocyst development in early embryogenesis of mice under cART. This study will contribute to health education about HIV and its treatment, boosting the reproductive health of PLHV and, importantly, improving their compliance with antiretroviral therapy - thereby aiding the achievement of the UNAIDS target of 2030. Furthermore, It will foster the mutual transfer of expertise in andrology and HIV-biology to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Concerted action for the setting up of an European veterinary network on diagnosis; epidemiology and research of mycobacterial diseases' (1994-1998).

assistant: **Concept**

Mycohacterial diseases, mainly tuberculosis and paratuberculosis (Johne'sdisease) are not only a threat to Public Health, but also the cause of massive financial losses due to condemnations and drop of the productions. Today, tuberculosis and Johne's disease can be a barrier to trade. The present concerted action is based on the will of the partners to share their technology and expertise in order to obtain a common knowledge on mycobacterial diseases that would help to eradicate tuberculosis and paratuberculosis from the countries of the European Union.Our objectives are:1. To coordinate the information about the problems encountered in the course of the ongoing eradication programs;2. Clarify existing or potential reservoirs of mycobacterial diseases among farm and wild animals, and how infection spread between them;3. Eradication of the diseases in existing reservoirs, as they represent a potential menace for Public Health;4. To exchange between partner practical knowledge of tuberculosis and paratuberculosis outbreaks, and how is depending on farming and trade practices;5. To perform epidemiological investigations and tracing of such outbreaks across no longer existing borders;6. Clarify quality of available data, and develop standardised collection of epidemiological data in cooperation with the Zoonosis Centers;7. Set up a databank on strain typing that will be maintained in each laboratory and that will he available for all scientific community;8. Collection of a representative number of data and strains that will he accessible to others partners for future cooperation research. The exchanges will follow strict guidelines;9. Exchange of expertise and scientific information, to avoid duplication of research and the un useful competition between groups or programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Symbol Elimination in Reliable System Engineering' (SYMELS).

assistant: **Innovation**

We are living in a world that is increasingly run by software. Daily activities, such as online banking, mobile communications and air traffic use, are controlled by software. This software is growing in size and functionality, but its reliability is hardly improving. We are getting used to the fact that that computer systems are error-prone and insecure. To (re)gain the trust of end-users in software and Web services, formal automated reasoning is one of the main investments made by ICT companies in preventing software errors. To improve in this area, one should answer some important questions, such as- Which methods in automated reasoning are the most appropriate for proving software error-free?- What needs to be done to apply research in automated reasoning to large-scale code bases?Our SYMELS project aims at answering these questions by bringing our symbol elimination method to the ICT market. The key innovation brought in by SYMELS is the ability to automatically generate and prove first-order properties of software that prevent programmers from introducing errors while making changes in this software. Our initial results show that symbol elimination can be a breakthrough method: e.g. when testing programs manipulating computer memory it was able to prove that over 80% of test cases are guaranteed to have the expected behavior. Most of these test problems were coming from industry, where similar proofs required very costly human work. Analyzing such programs requires reasoning about program properties in full first-order logic. No other method can reason about such properties with the same accuracy and expressiveness as SYMELS. For the proof-of-concept, SYMELS gives ICT customers and investors a tool-supported methodology for ensuring continuous growth in software
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Perceptual learning as optimized decoding: from maps to mechanisms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We usually think that as we emerge from childhood, our brains become less plastic, making learning effortful and highly specific. Recent findings however challenge this view, suggesting that even adult perceptual learning (PL), often considered the most specific form of learning, has the potential to generalize across training conditions. This questions classical theories positing that PL changes encoding in early sensory areas, as the functional properties of these areas cannot account for generalization. Building on recent computational models, I propose instead that PL relates to decoding, that is, how information from sensory areas is communicated and read out by higher areas to make decisions, because readout weights can be more flexibly adjusted and accommodate generalization. Decoding accounts are theoretically attractive yet technically challenging to test, as they require a multiscale brain investigation, i.e., tracking PL across networks, areas, and single neurons. I will address these theoretical and technical challenges by capitalizing on a recent innovation combining noninvasive neuroimaging with electrophysiological recordings while monkeys learn a discrimination task. This approach will allow for the first time to create a comprehensive map of brain areas involved in PL in monkeys, determine the involvement of connectivity changes to PL, and unravel the computations that the neurons in these specific areas perform. This project, at the intersection of neuroscience, psychology and computational theory, will set forth the foundations for a mechanistic investigation of PL at an unprecedented level of detail, bridging multiple scales from whole-brain networks down to single neurons, and will therefore allow me to start a competitive scientific career as an in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'In-situ wireless monitoring of on- and offshore WINd TURbine blades using energy harvesting technology' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project will develop an integrated system to monitor continuously the condition of wind turbine blades, without human intervention on site, using a novel integration of acoustic emission (AE) and long range ultrasonics (LRU). The system will use flexible light weight sensors. It will not be hardwired, deriving its power from energy harvested from the continuous flexing of the blade and transmitting its data to a unit housed in the nacelle using Bluetooth technology. The nacelle unit will transmit data by wireless to the wind farm’s central control base. The project will: - • Develop novel flexible transducers suitable for embedding in composite turbine blades with integrated AE and LRU capability enabling detection of flaws in the blades. This will be the first time that the same transducer array has been used for both AE and LRU functions. • Validate the reliability of the sensor/transducer systems and associated electronic modules through a stringent environmental test scheme. System assembly and potential manufacturing routes will also be established. • Develop a central software program with high-level functions comprising data collection, signal processing, data analysis and representation, information storage and user interface. Additional software will be developed to enable focusing of LRU at the point where AE has identified a significant potential failure source. • Undertake modular integrations of the sensors/transducers, signal processing and software functionalities to develop the prototypes and demonstrate its the capability to monitor and to reduce the maintenance costs of large scale wind turbines. • Develop an system based on the use piezoelectric actuators to harvest energy from the flexing of the blade and to use this energy to power the AE/LRU s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mountain Valorization through Interconnectedness and Green Growth' (MOVING), addressing dissemination and exploitation.

assistant: **Impact**

Mountain covers 36% of Europe area and play an essential role in the provision of public and private goods. Despite their relevance in both ecological and socioeconomic terms, we lack updated and comparable knowledge of the impacts of climate change, demographic trends and socioeconomic drivers in these areas; as well as the necessary policy-mix to address them. Advanced knowledge on the vulnerability of land use and production systems and related value chains; and on the long-term trends and dynamics affecting European mountains is necessary to design the next generation of policies.MOVING objective is to build capacities and co-develop policy frameworks across Europe for the establishment of new or upgraded/upscaled value chains contributing to resilience and sustainability of mountain areas, valorising local assets and delivering private and public goods.  MOVING includes: the screening of traditional and emerging value chains in all European mountain areas (including non-EU countries); in-deep assessment of Vulnerability and resilience of land use, production systems and value chains in 23 reference regions, accounting with the variability of the different mountains types; Participatory theory building to provide knowledge and assessment indicators; Participatory foresight exercises to inform about the future trends at regional and EU levels; Benchmarking analysis to identify enabling and blocking factors to value chains resilience. A policy roadmap will provide guidelines to support the design of public and private policy instruments that boost mountain areas resilience and provision of public and private goods.MOVING strongly relies on a Citizen-science-policy interface organised around a multi-actor approach: a Community of Practice formed by 23 multi-actor platf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEPLOYMENT OF DEEP ENHANCED GEOTHERMAL SYSTEMS FOR SUSTAINABLE ENERGY BUSINESS' (DEEPEGS).

assistant: **Innovation**

Our goal with the DEEPEGS project is to demonstrate the feasibility of enhanced geothermal systems (EGS) for delivering energy from renewable resources in Europe. Testing of stimulating technologies for EGS in deep wells in different geologies, will deliver new innovative solutions and models for wider deployments of EGS reservoirs with sufficient permeability for delivering significant amounts of geothermal power across Europe. DEEPEGS will demonstrate advanced technologies in three geothermal reservoir types that provide all unique condition for demonstrating the applicability of this “tool bag” on different geological conditions. We will demonstrate EGS for widespread exploitation of high enthalpy heat (i) beneath existing hydrothermal field at Reykjanes (volcanic environment) with temperature up to 550°C and (ii) very deep hydrothermal reservoir Vendenheim with temperatures up to 220°C that is located in the Upper Rhine Graben (URG), a tertiary-age NNE directional rift enclosed in the European Cenozoic Rift System (ECRIS). ECRIS is an 1100 km long system of rifts formed in the foreland of the Alps as the lithosphere responded to the effects of the Alpine and Pyrenean orogenies (The originally planned French demonstrators of Valence and Riom are also located in rifts belonging to the ECRIS system). Our consortium is industry driven with five energy companies that are capable of implementing the project goal through cross-fertilisation and sharing of knowledge. The companies are all highly experienced in energy production, and three of them are already delivering power to national grids from geothermal resources. The focus on business cases will demonstrate significant advances in bringing EGS derived energy (TRL6-7) routinely to market exploitation, and has potential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Interdisciplinary Crystallographic Contributions to Physical and Life Sciences: Techniques, Analysis, Synthesis, New Compounds'.

assistant: **Concept**

The Proposal Full Name stresses the connection between the three proposed SummerSchools. All topics foresee a varied degree of interaction between academia and industry.Crystallography is the branch of natural sciences concerned with the description of the detailed structure and the properties of condensed matter in terms of spatial relationships of its constituents, atoms, ions or molecules, in an extended three dimensional array: the crystal.The impact of X-rays (and other radiation sources) on crystals provides experimental data leading to the description of the arrangement of atoms, which in turn explains the behaviour of matter; where chemists, biophysicists, pharmacologists as well as materials scientists and solid state physicists have become involved in collaboration with crystallographers, the field has been flourishing; in addition, biotechnology and materials companies keep recruiting qualified crystallographers to work in their research laboratories, as their contribution becomes essential when trying to explore the dependence of properties on structure.The annexes intend to witness how intensely the purpose of past and future crystallography meetings at Erice is to provide (a scientific platform for the younger generation so that they achieve an advancement and exchange of ideas on stimulating topics and front line issues that traverse the boundaries of several of these disciplines.The official recognition of the multiplicity of aspects covered by crystallography comes from the Nobel Prize awarded in 1985 to H. Hauptman and J. Karle, frequently invited at Erice crystallographic meetings since they were started in 1974: the award was in Chemistry, for their sophisticated Mathematical approach to solve the phase problem" occurring during collection of x-ray d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Production of rhizobial soybean inoculants for sustainable agricultural use in china' in the context of a Fifth Framework call.

assistant: **Objectives**

The urgent need to develop commercial soybean inoculants for agronomic use to improve soybean yields in China has gone unanswered as effective inoculants for Chinese soybean cultivars are unavailable. We aim to produce high quality rhizobial inoculants for use with the soybean cultivars used in the major Chinese soybean cropping areas by isolating effective, competitive strains and developing protocols for local commercial production. Targeted fundamental studies of the best strains will underpin the applied studies, driving further improvements in the effectiveness of the strains and optimisation of their use. We expect to deliver a bilingual manual describing protocols for commercial inoculants production in China, a collection of efficient and competitive inoculants strains for local soybean cultivars, scientific results that allow us to further optimise their use, and training and exchange of expertise.