RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Hybrid Electrochemically-paired Light Irradiated Organic Synthesis'.

assistant: **Objectives**

The synergy of visible light and electrical energy has been employed for decades in water splitting to hydrogen, but only recently was used to power the synthesis of higher value complex organic molecules (natural products, pharmaceuticals). Synthetic photoelectrochemistry (PEC) is receiving notable attention due to its enhanced scope of redox transformations, sustainability, and selectivity compared to photo- or electrochemistry alone. Synthetic electrochemistry (EC) is a useful synthetic tool that replaces atom-uneconomical chemical redox agents with simple electrons and protons. However, in most EC reactions and in all PEC reactions, only one half-reaction of the cell is optimized to generate value; the other half-reaction sacrifices its own electrode or redox additives. Paired electrolysis, where both half-reactions afford useful species, is key to sustainability and efficiency.HELIOS will discover, develop and disseminate paired synthetic PEC reactions. Intermediates generated by both half-reactions are converged in novel, creative chemical transformations, including:i) marriage of radicals or ions generated by each half-reaction to furnish phenethylamines and azetidines, valued pharmaceuticalsii) ring-fusing reactions that furnish bicyclic scaffolds, toward molecules with high 3D character urgently required in drug discoveryiii) alcohol inversion reactions that are catalytic, environmentally-friendly and use mild conditionsMultifunctional catalysts will be used that can be electro-activated in both cathodic and anodic half-cells, to photochemically generate and stabilize reactive intermediates.HELIOS i) harnesses electrical and light energy to rapidly convert cheap, abundant chemical feedstocks to value-added complex molecules and ii) improves the sustainability a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Autoxitus: Molecular mechanisms and non-cell autonomous signalling' in the context of a Horizon Europe call.

assistant: **Objectives**

Cells control their content by balancing its synthesis and degradation. Autophagy is a key degradation process capable of engulfing large fractions of cells, including organelles, into double-membrane vesicles called autophagosomes. These fuse with lysosomes causing degradation of their cargo. Secretory pathways, including secretory autophagy, offer an alternative option to remove unwanted materials from cells. However, mechanisms allowing the secretion of larger cellular components are still unknown. We identified a novel pathway, which we termed autoxitus – for self (auto) exit (xitus) – that leads to the secretion of autophagosomes. This proposal aims at defining the molecular mechanism and regulation of autoxitus. We will first study how specificity and decision-making between secretory autoxitus and degradative autophagy routes is achieved and whether there is cross-regulation. Autophagosomes on the autoxitus route can contain parts of the cytosol, but also large fragments of organelles, raising the question whether the secreted autoxitus vesicles signal to neighbouring cells in a non-cell autonomous manner. We aim to uncover the impact of these signalling processes to determine whether and how autoxitus helps to signal stress conditions or may even deliver material or organelles to other cells. Finally, the role of autoxitus in two (patho-)physiological conditions will be analysed. Since autophagic processes are key to viral particle release, we will study the contribution of autoxitus to the viral life cycle. Furthermore, we will investigate the role of autoxitus in the release of protein aggregates from cells and the resulting seeding propensity.This proposal will give ground-breaking insight into autoxitus, its molecular underpinnings and physiological conseque
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Synthetic and scalable data platform for medical empowered AI'.

assistant: **Innovation**

AISym4Med aims at developing a platform that will provide healthcare data engineers, practitioners, and researchers access to a trustworthy dataset system augmented with controlled data synthesis for experimentation and modeling purposes. This platform will address data privacy and security by combining new anonymization techniques, attribute-based privacy measures, and trustworthy tracking systems. Moreover, data quality controlling measures, such as unbiased data and respect to ethical norms, context-aware search, and human-centered design for validation purposes will also be implemented to guarantee the representativeness of the synthetic data generated. Indeed, an augmentation module will be responsible for exploring and developing further the techniques of creating synthetic data, also dynamically on demand for specific use cases. Furthermore, this platform will exploit federated technologies for reproducing un-indentifiable data from closed borders, promoting the indirect assessment of a broader number of databases, while respecting the privacy, security, and GDPR-compliant guidelines. The proposed framework will support the development of innovative unbiased AI-based and distributed tools, technologies, and digital solutions for the benefit of researchers, patients, and providers of health services, while maintaining a high level of data privacy and ethical usage. AISym4Med will help in the creation of more robust machine learning (ML) algorithms for real-world readiness, while considering the most effective computation configuration. Furthermore, a machine-learning meta-engine will provide information on the quality of the generalized model by analyzing its limits and breaking points, contributing to the creation of a more robust system by supplying on-demand re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Together for RISc-V Technology and ApplicatioNs' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

TRISTAN’S overarching aim is to expand, mature and industrialize the European RISC-V ecosystem so that it is able to compete with existing commercial alternatives. This will be achieved by leveraging the Open-Source community to gain in productivity and quality. This goal will be achieved by defining a European strategy for RISC-V based designs including the creation of a repository of industrial quality building blocks to be used for SoC designs in different application domains (e.g. automotive, industrial, etc.). The TRISTAN approach is holistic, covering both electronic design automation tools (EDA) and the full software stack. The broad consortium will expose a large number of engineers to RISC-V technology, which will further encourage adoption. This ecosystem will ensure a European sovereign alternative to existing industrial players. The 3-year project fits in the strategy of the European Commission to support the digital transformation of all economic and societal sectors, and speed up the transition towards a green, climate neutral and digital Europe. This transformation includes the development of new semiconductor components, such as processors, as these are considered of key importance in retaining technological and digital sovereignty and build on significant prior investments in knowledge generation in this domain. Development strategies leveraging public research funding that exploit Open-Source have been shown to boost productivity, increase security, increase transparency, allow better interoperability, reduce cost to companies and consumers, and avoid vendor lock-ins. The TRISTAN consortium is composed of  46 partners from industry (both large industries as well as SMEs), research organizations, universities and RISC-V related industry associations, or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optical Resistance of Technologically Relevant Materials for ShortWavelength Laser Optics' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen Results1. Application of well-developed methods of solid state physics for the quality control of raw materials used  for optical components in SW laser systems; determination of physically established requirements for  purity and quality of raw substances; and new suitable wide-gap optical materials;2. Application of the methods of accelerator physics for investigation and treatment of the surface layers;  includes materials analysis by Rutherford backscattering (RBS) and Nuclear reaction (NRA), and materials modification by ion implantation. Both Salford and Ekaterinburg have these facilities, which  are complementary to each other;3. Improvement of reliability and maintainability of SW laser equipment, possibility of recycling expensive  optical materials, reduction of frequency of repairs and adjustments necessary after an exchange of damaged optical components;4. Improvement of environmental safety of excimer lasers due to the reduction of exchanges of windows  connected with a breaking of the seal of the active volume of the excimer laser containing aggressive  gases like C1 or F.This project proposes, as a result of close collaboration between research scientists and producers of laser and optical components for the ultraviolet and vacuum-ultraviolet spectral regions, a thorough investigation into the mechanisms which cause damage in the materials used during their operation. For this purpose a wide combination of methods available at the proposers' institutions shall be applied to examine the nature of the defects created and to find ways to avoid them.In addition to the improvements of materials in use today, this will include also the search for and testing of, new substances appropriate to this application.The participants have between them a vast st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Accelerated Real-TimE  Machine learning for Investigating the higgs Sector'.

assistant: **Objectives**

The discovery of the Higgs boson marked a milestone in particle physics, but crucial questions about how the Higgs boson interacts with itself and with heavy bosons remain unanswered. These interactions hold the key to understanding fundamental aspects of our universe, from particle mass generation to the nature of the cosmic phase transition in the early universe. Current measurements at the Large Hadron Collider (LHC) can only place weak constraints on these interactions due to significant limitations in our ability to identify and record the relevant collision events in real-time.This project introduces a revolutionary approach to overcome these limitations by developing advanced machine learning techniques for real-time event selection in particle physics experiments. The current approach discards up 50\% of potentially valuable collision events involving hadronic decays of the Higgs boson. By implementing sophisticated neural networks that can process collision data fast, this project aims to double the detection efficiency for these crucial events. The proposed system will operate at different stages of the data-taking process, from specialized hardware (FPGAs) to traditional computing infrastructure.The work will be carried out at the ATLAS experiment at CERN and will significantly enhance our ability to measure the Higgs boson's self-coupling, either leading to the discovery of new physics or placing stronger constraints on theories beyond the Standard Model. The PI brings extensive expertise in both Higgs physics and machine learning applications at the trigger level. An ERC Consolidator Grant will enable the formation of an independent research team with the necessary expertise to achieve these ambitious goals and advance our understanding of nature's fundamen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Large-scale and wide-band brain dynamics mediating memory consolidation in the freely moving rat' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Dementia is a major healthcare challenge worldwide due to its high incidence and its strong impact on the life quality of patients and on society as a whole. Development of treatments for the mitigation of memory impairment in patients with dementia has proven very challenging, partly due to our limited understanding of the underlying mechanisms of memory consolidation. Memory consolidation is mediated by communication between large-scale networks in the brain, particularly the hippocampal formation and neocortical circuits, coordinated by synchronous oscillatory dynamics, as shown in both humans and animal models during the resting state. In humans, this coordination is associated with complex resting-state network (RSN) dynamics that are reflected in spatio-temporal patterns of infra-slow (<0.5Hz) brain activity. However, the link between RSNs dynamics and well-understood neuronal dynamics underlying memory consolidation in animal models remains a major knowledge gap due to technical limitations. Wide-Band Ephys has a unique potential to close this gap by mapping extracellular potentials with high spatio-temporal resolution in a wide frequency band, enabling inference of RSN dynamics across brain-wide networks in freely moving rats. Using customized graphene-based neural probes in combination with Neuropixel 2.0 probes, fiber-photometry and optogenetics, I aim to investigate the mechanisms underlying memory consolidation with an unprecedented level of detail. Extending the current knowledge on the functional role of RSNs and local slow oscillations in the rat could lead to the development of novel treatments for dementia, which will be explored in collaboration with the private sector during this project. The interdisciplinary approach presented in this proposal will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Enhanced MUlti-Functional Membranes for Water Treatment and Desalination', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Enhanced-MUMs targets the development of advanced multifunctional and low-cost polymeric membranes for water treatment and desalination. The main innovation resides in the combination of enhanced structural properties (high porosity and reinforcement) for improved desalination characteristics and light-induced antifouling and antimicrobial activity based on the loading of photosensitizers in the polymeric membrane. The economy of the approach is guaranteed by the polymeric material chosen for the realization of the membrane: PVC. The proposed breakthrough relies on the complementary expertise of the Experienced Researcher on polymer chemistry and nanofibers fabrication and of the supervisor’s group on polymeric materials characterization, photochemistry of organic materials and photosensitizers for photodynamic treatments. Enhanced-MUMs is a multidisciplinary project that aims at bringing high innovation in the forefront research area of water treatment and desalination. In the frame of the project the Experienced Researcher will widen her scientific skills and technological know-how with significant improvement for the development of her career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lithium isotopes as a tracer for changes in interglacial-glacial weathering processes' in the context of a Seventh Framework call.

assistant: **Objectives**

Silicate weathering is a long term CO2 sink and silicate weathering rates influence, and are influenced by, climate change. Understanding the environmental factors which control silicate weathering rates will enable a greater understanding of both past and future global climate. This project focuses on the effect of climate change (on glacial-interglacial timescales) on weathering rates which is currently poorly understood. This is important not only for CO2 consumption by silicate weathering but also nutrient supply to terrestrial and marine ecosystems.  Weathering processes are expected to change during glacial-interglacial transitions and this project will quantify changes in weathering intensity over different time-scales using lithium isotope ratios. Lithium isotopes have been proposed as a sensitive tracer of weathering processes but a complete understanding of their behaviour in the weathering environment is still lacking. A three-pronged approach will be used which combines samples from lithologically identical glaciated and unglaciated catchments, laboratory experiments and a marine sediment core. All samples are derived from the high Arctic: a region which has witnessed repeated glaciation in the past and is the region on Earth most sensitive to modern climate change. The laboratory experiments will quantify lithium isotope fractionation as a result of specific weathering reactions, enabling differences in the lithium isotopic composition of field samples to be linked directly to specific weathering processes. Utilising the results of the field samples and laboratory experiments, the marine sediment core will be used to quantify how weathering intensity has changed in the past in response to well documented dramatic changes in climate. This will pave the way f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'U.a.s.b. anaerobic technology for low cost and sustainable wastewater treatment and re-use in mediterranean towns and villages.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Implementation and evaluation (2 years of R & D) of three demonstration U.A.S.B (anaerobic) Wastewater Treatment Plants(W.W.T.P.) in small towns of Mediterranean Area, to intro-duke this typical tropical" technology in the Region to reduce investment and O & M costs. Linked R & D with similar demonstration plants in Latin America. Commercialisation of the by-products (biogas/sludge/treated water) to support organic agriculture, to favours neighbours and to transform a W.W.T.P. into a tool for local sustainable development."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms of TET2 DNA demethylase recruitment to specific genomic regions' (TET2rec) under Horizon 2020.

assistant: **Objectives**

TET2 (Tet Methylcytosine Dioxygenase 2) is a DNA demethylase frequently mutated in patients with Acute Myeloid Leukemia (AML). DNA methylation is an epigenetic modification with key roles in the specification of cellular identity, and, when deregulated, in cancer. DNA methylation is a reversible process and, only recently, it was discovered that TET (Ten-eleven Translocation) proteins mediate DNA demethylation. Mammals have three TET homologues (TET1-3). While TET1 and TET3 share an N-terminal DNA-binding domain (CXXC motif), TET2 has lost its CXXC motif during evolution. Therefore, it is not understood how TET2 binds DNA. Due to the lack of a known DNA-binding domain in TET2, I hypothesize that TET2 may require to interact with proteins to be recruited to DNA, which is essential for its function. Hence, the main goal of my proposal is to understand how TET2 binds to DNA and to identify interacting proteins that participate in this recruitment. I also aim to unveil whether cancer-associated mutations affect TET2 recruitment.To achieve these goals, I will perform a structural-functional analysis of TET2. First, I will perform Chromatin Immunoprecipitation (ChIP) followed by whole genome sequencing of wildtype and truncated TET2. Thus, I will identify the region(s) required for the binding of TET2 to DNA. Next, I will seek proteins that interact with TET2 through the previously identified region by Mass Spectrometry and I will test their involvement in TET2 recruitment to DNA. Furthermore, I will perform similar experiments to inspect the impact of TET2 missense mutations found in human cancer on TET2 recruitment to DNA.Altogether, this project will yield a better understanding of how TET2 is recruited to DNA. The results obtained will significantly impact the epigenetic