RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-sensing polymer transistors for in vivo recording' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The computational power of the brain arises from the complex interaction and cooperation of a large number of neurons embedded in a functional network. Thus, a direct investigation of the temporal dynamics of neuronal populations (and structures) must address the simultaneous observation of multiple neurons. Most breakthroughs in our understanding of the basic mechanisms of information processing in the brain have been obtained with local field potentials (LFPs) and single neuron recordings in freely moving animals. Those measurements have been performed with silicon probes, but the process is prone to errors, since this technology suffers from several limitations, directly related to the materials used for the probe fabrication. In particular, the electrodes are not biocompatible and create tissue scars, they are rigid, and thus cannot compensate for small brain movements (as a result, a given cell cannot be recorded over extended periods of time). More important, information is only electrical and there is no information regarding how the system uses metabolites or how neuronal activity maintains the appropriate level of metabolites to operate properly. The purpose of MultiSENS is to develop a new generation of chronically implantable biocompatible probes displaying multi-sensing recording sites for monitoring brain activity. The most recent technology - organic electronics - will be used to address this issue. In particular, organic electrochemical transistors (OECTs) will be used as sensing sites for metabolites and ion current in situ measurements, thanks to their peculiar properties of strong ion-to-electron transduction, biocompatibility and mechanical flexibility. MultiSENS will make available multi-sensing probes capable of simultaneous in vivo recording of LFP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrating information from multiple web sources' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The task of a web information integration system is to answer queries that may require extracting and combining data from multiple web sources. The objective of the project consists of the extension of the query/ view model of mediation and management of incomplete and inconsistent information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'In vivo imaging of blood flow dynamics and cell migration in tumour microvasculature via real-time single nanoparticle tracking with positrons' (NanoFLOW), addressing dissemination and exploitation.

assistant: **Impact**

The tumour microvasculature consists of a disorganised network of immature blood vessels with aberrant dynamics and high permeability, which play a critical role in tumour growth, metastasis, and resistance to therapy. Despite its importance, studying blood flow dynamics and cell migration within this environment remains challenging due to the microvasculature's complexity, minute size, and structural irregularities. Positron emission particle tracking (PEPT), a technique that tracks a single particle radiolabelled with a positron emitter in real-time and 3D, offers a transformative solution to investigate such intricate systems. Widely used in industry to study complex flow dynamics, PEPT´s potential for biomedical applications remains untapped due to the lack of compatible single-particle tracers with sufficient radioactivity, nanoscale dimensions, and the ability to evade rapid sequestration.  I hypothesise that by overcoming these barriers, PEPT will provide unprecedented insights into blood flow dynamics and cell migration in tumour microenvironments.NanoFLOW aims to bridge this gap by integrating finely tuned single nanoparticle-based nanomedicines with advanced imaging technology. This project has four main objectives: i) To engineer nanoparticles with extended circulation times and tumour cell-targeting capabilities; ii) To achieve exceedingly high specific activity radiolabelled nanoparticles; iii) To develop microfluidic-based methods for accurate quantification and isolation of single nanoparticles; and iv) To validate PEPT in a fibrosarcoma mouse model. By addressing critical challenges in the application of nanomedicines, NanoFLOW will provide ground-breaking insights into tumour progression and metastasis, redefining the boundaries of nanomedicine and sett
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolving Nanocarbon Strategies in (bio-) Organic Remits' (ENSOR).

assistant: **Concept**

The ENSOR project involves the exchange of key staff between the EU (United Kingdom and Hungary), Russia and Japan with a principal aim to focus on the controlled production and chemical modification of a variety of novel nanocarbons for specific end applications reaching into the bio-organic field. Specifically, we will tailor the geometry and physicochemical properties of nanocarbons for the development of biosenors, rapid bacteria screening in liquid media, DNA therapeutics, regeneration of damaged cells (peripheral nerve cells) and hemoperfusion adsorption. It is also recognised that the development of novel nanocarbons will have unique properties that will be beneficial in other research and development fields, e.g. next generation of ultracapacitors, advanced organic decomposition catalysts, superior mechanical reinforcement additives. Furthermore, the project provides training and education through collating the best techniques available within each country to provide international excellence, facilitating transfer of knowledge and know how between the participating parties, being of mutual interest, fostering long term collaborative format well beyond the scope of the project.To ensure success of the project, it is necessary to organize joint investigations of four teams from the University of Brighton (UoB, UK), Budapest University of Technology and Economics (BME, Hungary), Omsk University (Omsk, Russia), Kazan State University (KSU, Russia) and Toyo University (Toyo, Japan). The complementarily aspects existing between EU partners and those from Russia and Japan, as well as the multidisciplinary character of proposed research will create sufficient synergy to succeed the targeted goals and will result cross-fertilization of the consortium as a whole.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Structural Basis of Ubiquitin Protein Ligation'.

assistant: **Innovation**

The attachment of Ubiquitin (Ub) to proteins (ubiquitination) is one of the most abundant post‐translational modifications in eukaryotes. Deregulation of the ubiquitination reaction is the cause of various diseases, including cancer. Ubiquitination is catalyzed by the sequential action of an activating (E1), a conjugating (E2), and a ligating (E3) enzyme. Ubiquitination enzymes contain catalytic cysteine residues that transfer Ub via thioester intermediates to a substrate lysine residue. The functional consequences of ubiquitination depend on the length and linkage of the attached Ub chain. While poly-ubiquitination commonly targets proteins for proteasomal degradation, mono- or multi-ubiquitination of receptor proteins serve as internalization or sorting signals. Interestingly, Ub ligases mediate both mono- and poly-ubiquitination depending on their substrates or other modulators. Although the basic principles of ubiquitination have been identified, the exact reaction mechanism underlying Ub protein ligation is still unknown. Furthermore, it is still unclear what determines whether a substrate is mono-, multi- or poly-ubiquitinated. To provide a structural basis of the ubiquitin protein ligation, we propose to use NMR spectroscopy in combination with biochemical tools to identify and characterize conformational changes and binding surfaces in HECT‐type Ub ligases at different steps of the ubiquitination reaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Soft Contact Mechanics', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

SOFT-MECH aims to shed light on the contact mechanics of soft materials, i.e. on the interactions between a “soft body” and its environment. This goal is motivated by the large variety of applications involving contact between soft rough bodies, which require an optimized design, and hence accurate knowledge of interfacial phenomena, in terms of stresses, friction and wear.  Components of interest include not only “traditional” products such as tires, seals and dampers but also a large variety of soft polymers used in profusion to achieve cost and size reduction, increased efficiency and biodegradability, making this project highly relevant to many new focus areas, such as bioengineering, nanotechnology and “green” technology, a key to the ERA quest for excellence and growth.The use and development of soft materials is partly hindered by the difficulty in accurately predicting their mechanical behavior.  Phenomena, such as hyperelasticity, viscoelasticity and porosity, make engineering design complicated and problematic. To address this unresolved issue, the applicant will develop advanced and rigorous numerical methodologies to model soft contact mechanics, accounting for both surface roughness and the presence of different phases (i.e. solid, liquids and gases) at the interface. This will be combined with an extensive experimental validation programme and the use of a range of novel techniques, such as in-contact thermal microscopy and high speed imaging.This challenging proposal is enabled by the unique set of modeling and analytical skills possessed by the applicant in conjunction with the world-leading expertise and facilities available at the Host Institution. The success of this industrially relevant project will produce a step change in the deployment of soft ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Promotion of the uptake of organic farming techniques through advanced vermicomposting technology and a scientific backup of its benefits and quality standards' (1998-2002) under Fifth Framework.

assistant: **Objectives**

'Ive aim of the proposed project is to promote the use of vermicompost through advanced vermicomposting technologies and in conjunction with sound scientific backup of its benefits and quality standards. Improving and promoting the production of vermicompost, evaluating its benefits, defining quality standards and by helping farmers to take advantage of this bioorganic approach will achieve this. The public will benefit from greater recycling organic waste and from the agricultural benefits (e.g., plant nutrients and pest and disease suppression) of using vermicompost. Food quality will be enhanced and the EU will benefit from data gathered about potential improvements in soils that will make organic, sustainable farming more viable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Co-operative ITS Systems for Enhanced Electric Vehicle Mobility' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Mobility2.0 will develop and test an in-vehicle commuting assistant for FEV mobility, resulting in more reliable and energy-efficient electro-mobility. In order to achieve a maximum impact, Mobility2.0 takes an integrated approach of addressing the main bottlenecks of urban FEV mobility: 'range anxiety' related to the limited FEV range, scarcity of parking spaces with public recharging spots, and the congestion of urban roads. Our integrated approach means the application developed by Mobility2.0 will utilise co-operative systems to simultaneously consider these bottlenecks, so that such an optimisation can be achieved which still guarantees reliable transportation for each FEV owner. Mobility2.0 will focus on assisting the daily urban commute, which represents the bulk of urban mobility.<br/>Mobility2.0 outcomes will be the following: an FEV-specific multi-modal urban guidance application implemented for prolific smart-phone platforms; this application will include the integrated reservation of a suitable FEV recharging spot, while also prioritising FEVs with low battery levels for the reservation, and making optimal use of the available public transportation along the journey. the above application will include the capability to allow municipal/utility control over the temporal and spatial aspects of recharging; the corresponding tools will be dynamic electricity pricing and a map analysis framework end-to-end validation of the above results at two test sites the project will specify the scalable broadcasting of FEV recharging spot notification over 5.9 GHz networks the project will specify the technology which enables FEVs to act as 5.9 GHz road-side units<br/>Besides FEV manufacturing, FEVs may also be produced by the conversion of traditional vehicles into FEV
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Promotion and facilitation of international cooperation with Eastern European and Central Asian countries'.

assistant: **Concept**

The EECAlink is a coordination action aimed at identification of joint research priorities of the EU and EECA countries and strengthening scientific collaboration among them. International Cooperation Partner Countries targeted by our proposal are: Armenia, Belarus, Georgia, Kazakhstan, Moldova, Russia, Ukraine and Uzbekistan.  EECAlink represents (i) a measure of active encouragement of the international Health research related cooperation and allows (ii) strengthening of the existing bi-lateral scientific collaboration of all participating university/academia partners. Project consortium was balanced to be able to act as a pipe-line for communication of the (iii) research priorities of EECA countries to relevant EU policy makers and vice versa, (iv) help to coordinate future joint calls relevant to the Health Theme. Last, but not least, (v) to build capacities for proposal submission in FP7.  EECAlink is proposed to run for 30 months. For the project communication and impact evaluation purposes, we have defined three major target stakeholder groups: 1. Policy makers – this target group is further divided into (i) European and (ii) national. The first stakeholder group represents a key element for creation of European added value through identification of joint research opportunities for future calls in the area of Health research  2. Universities and academia partners – the project is coordinated by the Charles University in Prague and represents a consortium of ten academic partners, who wish to both strengthen and extend their international collaboration in topics identified in FP7-TP Health programme  3. Wider RTD public – research and innovation managers and individual scientific group leaders from participating countries interested in submitting own FP7 proposals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Moving a novel gene therapy paradigm to treat  blindness to the market' (2014-2020) under Horizon 2020.

assistant: **Objectives**

At present therapies for inherited dominant disorders are not available, thus representing an urgent unmet medical and social need. The ERC Grant ALLELECHOKER enabled the PI to discover three modes to generate transcriptional repression by transcription factors (TFs) based on Zinc-finger scaffold: i- synthetic transcription factor (TF; Mussolino et al., EMBO Mol. Med. 2011 Mar;3(3):118-28; Botta S. et al. Elife. 2016 Mar 14;5), ii- synthetic DNA-binding protein (Botta S. et al. Elife. 2016 Mar 14;5) and iii- the ectopic expression of an endogenous TF (Botta S, et al. JCI Insight. 2017 Dec 21;2(24). Thus, the PI demonstrated that transcriptional repression by TFs embodies a novel therapeutically effective mode to treat the toxic effects of gain-of-function mutations causing incurable inherited dominant disorders. In particular, mutations in the RHODOPSIN gene can cause the blindness disorder autosomal dominant retinitis pigmentosa (adRP). The PI demonstrated safety and efficiency of RHODOPSIN gene transcriptional silencing in pre-clinical animal models by a specific synthetic transcriptional repressor (ZF6-DB) delivered to the retina by an adeno-associated virus (AAV) vector (AAV-ZF6-DB). Furthermore, within the ERC Grant ALLELECHOKER the PI showed that a single AAV vector containing two independent expression cassettes (AAV-ZF6-DB-hRHO), enables balanced silencing of RHODOPSIN by ZF6-DB and its simultaneous replacement with a human wild-type copy of the RHODOPSIN gene. The primary objective of the inSight ERC-PoC grant is to support AAV-ZF6-DB-hRHO clinical translation, with the final goal of bringing this therapeutic to patients suffering adRP through market authorization and commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Using echoSOUNDer data from fishing vessels to TRACK ecosystem impacts of the krill fishery'.

assistant: **Objectives**

SOUNDTRACK is a project that combines deep learning methods in acoustic data analysis with field sampling and fisheries science toinvestigate the ecosystem impacts of the Antarctic krill fishery and to improve its management. Antarctic krill is a key species in the Antarctic marine ecosystem and the target of a growing commercial fishery. Given krill's ecological importance, concerns have been raised about potential negative ecosystem impacts from fishing. Resource-efficient approaches to support fisheries monitoring are particularly valuable in this context due to the high costs associated with data collection in Antarctica. In SOUNDTRACK, we will first develop a segmentation model to extract dives of air-breathing krill predators, such as whales, seals and penguins, from historical acoustic data recorded by krill fishing vessels during their operations. Acoustic data from fishing vessels are under-utilised, but provide a rich archive of observations of krill swarms and vessel interactions with krill predators. Analysing the frequency of vessel-predator interactions, and their temporal and spatial occurrence in relation to krill distribution and predator demand for krill, will provide new perspectives on the ecosystem impacts of the fishery, using cost-effective data and platforms as a co-benefit. We will complement the analysis of the acoustic data by conducting an ecosystem survey at the Antarctic Peninsula in autumn 2027, coinciding with the fishing season in this region. By combining the scientific survey data with acoustic observations from fishing vessels from the same region, their fleet movement patterns, and the life stage composition of the krill caught, this approach will allow us to provide a detailed analysis of ecosystem impacts of the fishery. The implic