RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Legitimate crisis management and multilevel governance' (LEGITIMULT), addressing dissemination and exploitation.

assistant: **Impact**

LEGITIMULT assesses the impact of the measures taken by various international, national and subnational governments on multilevel institutions and intergovernmental relations in the wake of the Covid-19 pandemic. The project analyzes the effect of these measures on democratic governance, highlighting to what extent multilevel governance influences  their impact on democracy, favoring a model of legitimate crisis management. It assesses all measures taken by 31 European countries in relation to their impact on multilevel governance through the creation of a new dataset highlighting how these procedures link to multiple orders of governance – WHO and EU above the states, and regional and local governments below the national level. The impact of these measures is analyzed through the lens of a variety of dimensions that characterize functional democratic governance (Rule of Law and Democratic Participation; Human and Minority Rights; Trust; Economic Sustainability). LEGITIMULT qualifies the different trade-offs required within and across these dimensions in order to effectively and quickly deal with a crisis such as Covid-19, while at the same time maintaining a level of democratic governance and ensuring that any limitations to democratic standards are limited. These final trade-offs within and between the different dimensions of democratic governance in crisis management are gathered in a set of policy recommendations, tailored to different recipients, and developed through extensive consultation with stakeholder groups throughout the project. Citizens, policy makers and practitioners are involved in the experimental phase of the project, where interactive learning and practical tools are tested but also co-designed and co-refined with relevant stakeholders in a particip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhanced Personal, Intelligent and Mobile system for Early Detection and Interpretation of Cardiological Syndromes' (EPI-MEDICS) targeting Fifth Framework.

assistant: **Abstract**

Because of a continuously growing number of cardiac patients in Europe, the only practical way to decrease the overall cardiac mortality and morbidity is to supply the citizen with a portable care device that will allow him to monitor his health status and early detect cardiac events such as ischemia and arrhythmia.EPI-MEDICS will design a solution based on the interpretation of ECG derived cardiological syndromes and develop a friendly and easy-to-use, cost-effective and intelligent personal device that may be used anywhere, anytime. The device will be able to record and store ECG signals with a professional quality level, incorporate intelligent self-adaptive data processing and decision-making techniques, generate different levels of alarms, and forward the alarm messages with the recorded signals to the relevant health care providers by means of new generation wireless communication devices.Objectives:Heart disease is the main cause of early disability and premature death in western countries. Moreover, because of the ageing of the population, the number of cardiac deaths is steadily increasing. However, the only available diagnosis tool useful for assessing the probability of cardiac events is the electrocardiogram (ECG). But, most of the cardiac deaths occur outside of the hospital. So, new strategies are required to reduce the time before treatment. The challenge is two fold: detect as early as possible the onset of arrhythmias and schema events by monitoring the changes of the ECG of the citizen at risk, and then involve without delay, but only if necessary, the health care structures. The aim of the epi-medics project is to develop and experiment a novel intelligent" Personal ECG Monitor (PEM) for the early detection and management of cardiac events. The object
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European learning GRID infrastructure' in the context of a Sixth Framework call.

assistant: **Objectives**

The European Learning Grid Infrastructure (E-LeGI) project has the ambitious goal to develop software technologies for effective human learning. With the E-LeGI project we will promote and support a learning paradigm shift. A new paradigm focused on knowledge construction using experiential based and collaborative learning approaches in a contextualised, personalised and ubiquitous way will replace the current information transfer paradigm focused on content and on the key authoritative figure of the teacher who provides information.We have chosen a synergic approach, sometimes called human centred design, to replace the classical, applicative approach to learning. With consideration of humans at the centre, learning is clearly a social, constructive phenomenon. It occurs as a side effect of interactions, conversations and enhanced presence in dynamic Virtual Communities: experimental research concepts integrating new powerful developments of services in the Semantic GRID, the leading edge of currently available and future ICT technologies, with highly innovative and powerfully significant scenarios of human learning.The E-LeGI project has three main objectives:- To study and define new models of human centred learning enabling ubiquitous and collaborative learning, merging experiential, personalised, and contextualised approaches.- To study, design and implement an advanced service-oriented Grid based software architecture for learning. This will allow us to access and integrate different technologies, resources and contents that are needed in order to realise the new paradigm according to Objective 1.- Within the context of a single Integrated Project, we will research, develop, deploy, validate, and evaluate the GRID based software architecture for learning and the h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of the circadian chromatin landscape using a novel CRISPR/Cas9-guided proximity-labelling technique' to be submitted under Horizon 2020.

assistant: **Abstract**

To stay in synchrony with environmental cycles, most living organisms possess endogenous clocks. Circadian clocks are molecular oscillators present in most mammalian cells that drive circadian (~24 h) rhythms of a wide range of molecular, physiological and behavioral functions. Circadian clocks are essential for health. In humans their dysregulation (e.g. caused by shift work, jet lag etc.) has been associated with the development of multiple pathologies (e.g. cancer, metabolic diseases like diabetes and obesity as well as cardiovascular and neurodegenerative diseases) prevalent in the European Union.One central aspect of molecular oscillator function is the tight regulation of circadian transcription. Over the years, several proteins and cis-regulatory enhancer elements (i.e. specific sequences located around the promoter region, e.g. E-box, RRE, D-box) have been shown to be essential for circadian transcription. However, mainly because of technical limitations, those studies focused on few regulators and have left many gaps in the understanding of the dynamics of the circadian transcription. Therefore, this project proposes to use state-of-the-art quantitative genomic-locus proteomics to provide the first comprehensive and unbiased characterization of the rhythmic protein binding at key circadian regulatory regions – a key regulatory node of circadian clock function Using a CRISPR/Cas9-APEX labelling method (CASPEX), we will first characterize the circadian chromatin landscape of the three main circadian regulatory regions (i.e. E-boxes, RREs, D-boxes). We expect to find new clock modifiers, whose role for circadian rhythm generation will be investigated in a subsequent part of the project, using an RNAi-based secondary screen. Overall, this project will provide novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A PATCH OF LAND: RE-CONSIDERING WORK AS A LIFE-SUSTAINING PRACTICE IN THE POST-SOCIALIST SEMI-PERIPHERY THROUGH INTERGENERATIONAL CHILDHOOD MEMORIES'.

assistant: **Innovation**

PatchWORK explores work in the context of sustainable land cultivation in the post-socialist semi-periphery as a life-sustaining practice embedded in more-than-human relationality, reciprocity and care through the lens of intergenerational childhood experiences. The project aims to open up alternative trajectories towards sustainable co-existence with our living environments through work, and to develop a theory of work that is not caught by mere economic rationality, but is embedded in a human and-more-than-human relationality. Three central approaches contributing to the retheorization of work underlie this project: 1) thinking through childhood memories approach enables to document and examine  mundane intergenerational sustainable practices and human and more-than-human relationalities that fall outside of contemporary science's attention; 2) a post-socialist decolonial approach that seeks to bring into view those knowledges and practices that have been subjugated by Western environmentalism and contest 'necro-' and 'turbo-neoliberal capitalism' and its land practices; 3) an intersectional approach to age, gender and social class that allows for an analysis of gender relations and social class in relation to children's participation in sustainable practices. PatchWORK employs an innovative interdisciplinary methodology that includes sensory walks, collective biography workshops, citizen science and secondary analysis from previous ethnographic fieldwork. Retheorizing 'work' as the main outcome of PatchWORK will contribute to scientific advances across disciplines with two co-authored articles, an English-language monograph, and a museum exhibition.PatchWORK will contribute to re-theorization of work, to the inclusion of childhood in mainstream theory, and to the dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of Clinically Useful Biomarkers for IGF-I Receptor Signalling n Cancer' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The Insulin-like Growth Factor I Receptor (IGF-IR) is widely expressed on human tissues and has been shown to promote the growth and invasiveness of cancer cells. It is a potentially important therapeutic target for several major cancers including breast, lung and colon, and has attracted major interest from pharmaceutical companies and clinicians. Currently, at least 70 clinical trials are underway to test several different IGF-IR kinase inhibitors and blocking antibodies. However, unlike some other growth factor receptors the IGF-IR is not amplified or over-expressed in cancer. One of the major challenges to targeting the IGF-IR in cancer is the lack of suitable biomarkers that will a) assess IGF-IR activity in tumours, b) facilitate selection of patients and subsets of tumours that are most likely to respond to inhibitors, and c) monitor responses to IGF-IR inhibition. This programme aims to address this problem by identifying and validating biomarkers for the IGF-IR signalling pathway in cancer. This programme involves a collaboration between researchers at University College Cork who are experts in IGF-I signalling and researchers at Almac Diagnostics who are experts in pharmacogenomic approaches to biomarker discovery in cancer. The research plan will take two complementary approaches: 1) explore the potential of a list of candidate genes that have already been identified in a screen for IGF-IR activity in cancer; and 2) carry out an unbiased genomic screen using a combination of cell models selected as models for IGF-I signalling and proprietary databases that have been collated from different sources, including patient data. The research programme is highly collaborative and includes extensive transfer of knowledge and experience, and exchanges of researchers be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation Relay Center Project: Offering a complete range of services to support regional SMEs and laboratories in transnational technology transfer achievement. The project cover 4 regions on the#' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The members of the Centr Atlantic IRC are all involved in supporting innovation and technological development in the region. The proposition has been constructed to build on these competences, and the wide experience gained from eight years participation in the CRI. CentrAtlantic IRC covers four regions on the west of France: Basse Normandie, Bretagne, Centre and Pays de la Loire.The partners involved in this project already work closely at a regional level in offering innovation support. To address the identified technological requirements of the region and the priority sectors identified by the commission, eight thematic projects have been selected for intense activity. Transversal activities in TO/TR diffusion and communications, together with promotion of other sectors, will ensure the full spectrum of industry is coveredThe strategic objectives are:1- Facilitating TTT that correspond to the needs of regional SMEs2-Providing a value added service to support innovation and technological development.3-Enhancing synergies and exchanges of our partners at regional, national, and European levels.4 Consolidating and developing our current position as a node for innovation and TTT in our regional environment. IRC activities are of three types: awareness, contact and assistance. The expected results are: 700 visits, 200 audits, 12 seminars or conferences, 20 brokerage events, 8 companies missions, 8 trainings Participation to 5 thematic groups800 clients, 300 new clients, 100 TO and 40 TR published 800 EOI, 400 matches, 100 negotiations, 40 TTT and 8 started negotiations R&D result exploitation. The IRC has the technical expertise, the experience and the facilities to successfully promote TTT across the West of France. The light management structure combined with a targeted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Micro-Scale Photonic Trace Gas Sensor' in the context of a Horizon Europe call.

assistant: **Objectives**

The demand for highly sensitive trace gas detection down to part-per-billion (ppb) levels and exceptional selectivity is paramount across various fields, including environmental monitoring, industrial process control, and healthcare. Currently, such capabilities are only accessible through bulky and expensive high-end sensors, limiting their use primarily to research settings. However, the ERC Starting Grant project sCENT has recently achieved a significant breakthrough by demonstrating the first chip-scale sensor capable of ppb-level detection and selectivity equivalent to that of high-end instruments. These sensors merge the strengths of high-end commercial spectroscopic systems, offering sensitivity, selectivity, isotope detection capability, and long-term stability, while also being compact, lightweight, and requiring only microlitre sample volumes. This success was possible due to a pioneering waveguide design supporting air-like modes, demonstrated within the ERC Starting Grant sCENT.The current project aims to explore the disruptive innovation potential of the sCENT sensor concept, advancing it from a proof-of-concept to the next level of technological readiness. This entails (i) the development of a prototype module and (ii) its real-life application demonstration to study the metabolic emissions of methane-consuming bacteria native to permafrost soils.Additionally, the project encompasses crucial aspects such as IP protection management, monitoring target markets (primarily environmental intelligence), and designing a technology roadmap for the sensor's exploitation. Outreach activities are meticulously planned to promote the sensors to potential commercial partners, end-users, and stakeholders. The overarching vision for the sCENT sensor is to unlock new oppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Systematic Genetic Code Reprogramming' (SGCR).

assistant: **Innovation**

We will build an orthogonal translation system for the encoded synthesis of unnatural polymers in cells. The steps towards this goal are each significant and substantial and, importantly, our solutions for each step are both scalable and modular with those for other steps in the process.   In the first step we create a scalable and modular route to multiple new aminoacyl-tRNA synthetase/tRNA pairs that are orthogonal to each other and to endogenous synthetases and tRNAs.  In a second step we engineer a cell for orthogonal translation to enable each orthogonal tRNA to quantitatively and efficiently decode a distinct quadruplet codon.  In a third step we invent a modular and scalable route to program the active sites of mutually orthogonal synthetases to uniquely recognize distinct unnatural building blocks.  The modular combination of the advances in each step enables the conversion of genetic code expansion with one or two unnatural amino acids into a scalable technology for genetic code reprogramming, facilitating the encoded synthesis of unnatural polymers using a synthetic genetic code with more encoded monomers than the natural genetic code.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Light Amplifiers with NanoClusters and ERbium' (LANCER).

assistant: **Concept**

The proposed project will realise compact, high-performance, CMOS-compatible and cost-effective planar optical amplifiers and lasers for next generation optical networks. The drive to combine the functionality of silicon electronics with optical data transmission to yield silicon opto-electronic integrated circuits operating at 1.5 ¿m is currently a technological priority of  both the communication and the microelectronics communities. The present proposal intends to exploit the quantum properties of Si nanoclusters (Si-ncs) to efficiently excite erbium ions, which are the optically active species responsible for light amplification. In this way, the project will overcome the principal problems that have precluded the development of such amplifiers to date: poor emission efficiencies of erbium in silicon, small excitation cross-sections for erbium in silica, the requirement for expensive pump sources. The project will exploit two approaches: hybrid and monolithic integration. The hybrid approach will involve, for example, flip-chip bonding of an ion-exchanged glass waveguide with a planar Er/Si-nc codoped layer. Monolithic silicon amplifiers will be fabricated by co-doping silicon waveguides with Si-ncs and erbium ions. The devices will be electrically and/or optically pumped, the latter using a low-cost LED. Planar packaged devices with gains of 10dB less than 5cm in length are envisaged, allowing the deployment of inexpensive photonic components for metropolitan networks and fibre-to-the-home.The consortium includes universities, research centres active in electronics, signal processing and advanced optics, and a well-established SME in the field of optical subsystems.