RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'RAdio DIgital Am TEsts' (RADIATE) targeting Fifth Framework.

assistant: **Abstract**

The Radiate Project will trial and promote the new ITU standard for digital broadcasting of audio and data in the AM bands at frequencies below 30 MHz using a system developed by the DRM consortium. The Trial will utilise prototype transmitter exciters for both the Short and Medium Wave bands, using modified existing transmitters located around the world and received on prototype receivers. The objectives of the trial are to: confirm the operational effectiveness of the system and support submissions to the ITU for final acceptance of the DRM system; demonstrate the DRM system's compatibility with existing transmissions; prove the commercial viability of the system and support the development of commercial support tools and equipments; promote its acceptance within and outside Europe; and ensure that European and associated organisations are well placed to take a leading role in the utilisation and commercial exploitation of the new medium.Objectives:To verify that digital broadcasting in the AM bands, 30MHz is viable using the standard and system developed by the DRM consortium.To confirm that the DRM system features operate as expected over a broad range of reception conditionsTo show that the expected improvement in both audio quality and reception reliability is consistently achievedTo demonstrate data transmission using the DRM systemTo confirm that the ITU requirements for digital systems are metTo demonstrate that DRM broadcasts comply with broadcast legislation and can co-exist with analogue broadcastsTo gain experience in adapting existing transmitters for DRM useTo collect and analyse data from the transmitters and receiversTo gain sufficient operating experience to enable the partners, to have an advantage in the operations and commercial exploitation of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A natural framing of knots' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content To deepen the understanding of how many intersections of which sign of boundary with interior a disk in 3-space must have, depending on the knot type of the boundary; to study the relations between these numbers, and other, better known knot invariants, and how they reflect the interactions between the topological and geometric properties of knots. More specifically, to illuminate the relation between the 'natural framing number', the signature, and the unknotting number of knots, to calculate the natural framing of Seifert fibred knots, to give formulae for satellite- and two bridge knots, and, in the case of hyperbolic knots, to investigate the geometric meaning of the natural framing number. Training content (objective, benefit and expected impact) To deepen my understanding of the geometric properties of knots and knot groups. To establish myself as a researcher in geometric topology and 3-manifold theory, by way of profiting from and contributing to the team of topologists at the U Provence. Links with industry / industrial (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'e-DNA BotStop', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the last decade there has been an explosion in Online Travel Agents (OTAs) worldwide. OTAs undertake the mammoth task of undercutting the flight prices of major airlines through the use of Bots (an internet Bot, also known as web robot, WWW robot or simply bot, is a software application that runs automated tasks (scripts) over the Internet.). Bots are used to scrape airlines for valuable data to benchmark aggregate flight costs, which drives down prices for the consumer.Whilst beneficial to consumers, scraping harms travel companies because:•Bots can engage with a websites’ server hardware and cause website traffic to run slower, in some cases causing server downtime and Direct Denial of Service (DDoS)•Long term Search Engine Optimization (SEO) damage; distorting analytical marketing metrics.•Diverting customers to purchase products via third party resellers, limiting chances for up-sell and cross sell opportunities. This problem is tackled by anti-scrape approaches.  However, current anti-scrape/booking bot solutions are only capable of distinguishing between human traffic and bot traffic through supervised algorithms that do not work to the degree of efficacy required. Our proposed solution is BotStop an algorithmic approach to identifying Bots and scrapers and to policing malicious application traffic.  eDNA will provide a solution which reintroduces transparency into the process of purchasing flights and will streamline customer website experience to ensure a more stress-free experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Policy decision support for sustainable adaptation of china's agriculture to globalisation.'.

assistant: **Innovation**

China's accession to the WTO, its fast rising demand for animal products and continuing population growth call for major changes in its agriculture and land management policies. While trade liberalisation will ease pressures on demand, it will also trigger a rapid process of transition with diverse impacts on the various regions of China, owing to their differing social setting, ecological conditions and specialisations. CHINAGRO will conduct an informed policy dialogue between institutions in China to analyse a range of policy scenarios over the period 2001-2030 in the light of WTO commitments, and the policy needs as formulated in the Agricultural Action Plan for China's Agenda 21. The dialogue and extensive training courses will involve international experts and be organised around scenario simulations with an existing regionalised model, to be adapted and updated during the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Improving the Management of Unexplained Chest-pain'.

assistant: **Innovation**

The iMUC project is designed to validate the improvement of cardio vascular outcomes in patients with unexplained chest-pain using a novel methodology of endothelial function diagnosis and adjusting their treatment, including life style modification, accordingly. iMUC is focused on the validation of a new biomarker based non-invasive novel technology which detects and scores endothelial dysfunction in cardiovascular disease  through the different  states of the disease.iMUC EndoPATTM diagnostic technology is based on the PAT® signal biomarker developed by Itamar Medical. It is a non-invasive, robust and totally non-operator-dependent technology and thus could fit well into clinical settings, providing an enhanced tool to improve disease management.iMUC aims to validate that endothelial function as scored by the iMUC technology can help to better manage patients with chest pain that undergo diagnostic angiography and are released without intervention. In addition, iMUC aims to show and validate in the same patient population that adherence to and compliance with intensive life style changing is improved when progress is followed and monitored with the novel iMUC technology. iMUC Phase I study will focus on the development of a business plan, and on a feasibility study of the project's concept. It will conduct a clinical market research quantifying the relevant market segments as well as their size, by studying the related health care economic viability, and the relevant scientific literature. iMUC feasibility study will include the establishment of a steering committee composed of relevant Key Opinion Leaders (KOLs), the detailed design of the project clinical protocol, the plan of the project risk management, as well as conducting a partner search including medical cent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on ''Systems' study of cellular growth, shape and polarity'.

assistant: **Innovation**

A major challenge of modern biology is to elucidate how cellular structure and function result from the systemic action of the genome and proteome. In this proposal, we describe an integrated approach combining high-content and quantitative microscopy, systematic gene knockouts, and computational/theoretical methods to carry out the most detailed systemic study of three key aspects of cell physiology: growth, shape and polarity. We will use the fission yeast Schizosaccharomyces pombe as experimental model organism. The haploid fission yeast with its relative genomic simplicity, genetic tractability, uniform size and shape, and well-characterized, conserved and simple growth and polarization machinery is ideal for this study. A better understanding of the systemic regulation of those processes is likely to contribute in the long run to the development of better strategies to fight cellular pathologies associated with many diseases, such as cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Partnerships for rural integrated development in Europe' (PRIDE).

assistant: **Concept**

The principal aim of the project is to explore how and how far locally- focused partnerships do indeed stimulate rural development - as is by now generally claimed or assumed - and thereby to improve the theory of rural development and the practice of its delivery in the next period of Structural Fund expenditure. The objectives of the 24 month project are: - to explore, in six EU member states, the effectiveness of local partnerships as a tool of rural development; - to explore the origin, development, structure and operation of such partnerships; the partners themselves; - to identify those elements of partnership which induce or, conceivably, constrain development; and The work will be undertaken by six academic research units/institutes, based in the UK, Finland, Germany, Italy, Sweden and Spain. Fieldwork will be concentrated within two regions with objective 1 and objective 5b status in each of the six member states. It will begin with a 'census' of relevant local partnerships in each region. Then, in each region, two partnerships will be subjected to detailed analysis - i.e. 24 partnerships in all. This analysis will be in two stages, the first concerned with the structure and operation of the partnership, the second with its impact upon both the development of the local area and the partners themselves. Six national-level and one European workshop will be convened to consider the draft findings of this research before the Final Report is written. Those benefiting from the research will include agencies involved in rural development at the European, national, regional or local levels plus anyone involved in local partnerships with a development remit. More fundamentally, rural residents and firms stand to benefit, especially those in disadvantaged areas, as the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EARA Early Stage Training in Astrophysics' (EARA-EST) under Sixth Framework.

assistant: **Objectives**

This EST proposal is presented by the European Association for Research in Astronomy (EARA) a consortium of five leading European research institutions in astronomy: the Institute d'Astrophysique de Paris (lap), the Institute of Astronomy (Loa) in Cambridge, the Sterrewacht Leaden, the Max-Planck Institute fur Astrophysics (MPA) in Arching and the Institutor de Astrophysical de Canarias (lack). EARA, which was founded twelve years ago, has been designated during the 5th Framework Program as a joint Marie Curie Training Site. The five EARA laboratories have broad scientific interests, covering mostly all aspects of astrophysics and cosmology. They host internationally recognized experts in theoretical astrophysics (theory and numerical modelling and simulation) and observational astronomy who have a large access to some of the most modern astrophysical instruments and facilities. Comprehensive doctoral study programs are available at all EARA sites, which have a long experience in training young researchers in astrophysics. The FP5 Marie Curie Training Site 'EARASTARGAL' has been very successful and the aim of this EARA - Early Stage Training in astrophysics (EARA - EST) proposal is to capitalize on our experience in scientific training and collaboration acquired in the last years with short-term student exchanges. The possibility within FP6 to offer long-term fellowships is very attractive and answers a strong demand for increasing collaborative European PhD projects. The EARA consortium indeed has the capacity to organize European PhDs with a coordinated supervision of a student by the best experts in several institutions (for example by combining a theoretician with an observer or a radio astronomer with an optical astronomer, etc). In summary, EARA-EST is the continu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cultured Liver Organoids for Investigation and Treatment of Inherited Cholestatic Diseases' to be submitted under Seventh Framework.

assistant: **Abstract**

Bile synthesis and secretion are crucial to liver function and involve multiple proteins. Disorders due to defects in this process (Inherited Cholestatic Disorders, ICDs) lead to progressive liver disease. Many ICD patients do not respond to medical treatment and need liver transplantation (LT). Although ICDs are rare, multifactorial cholestatic diseases are common and many patients will benefit from ICD research.There is acute shortage of liver donors. 10% of patients die while waiting on the liver transplant list. Therefore alternatives to LT are urgently needed. Bioengineered tissues may reduce the need for donor organs but complexity of it's organisation makes generation of functional liver challenging.The OBJECTIVE of this project is to generate Cultured Liver Organoids (CLOs) using hepatocytes cultured on 3-D scaffolds as novel models for study of liver development and disease and potential treatment of ICDs.3-D extracellular matrix (ECM) scaffolds derived from decellularised livers and polymeric matrices (PM) have been used to mimic liver architecture but further work is needed to establish functional bile flow.Human Induced Pluripotent Stem Cells (hIPSCs) derived from reprogrammed skin fibroblasts by overexpression of pluripotency factors can proliferate and be differentiated into various cell types including hepatocytes. hIPSCs enable production of patient specific cells, which are fully immuno-compatible. Genetically corrected mutant hIPSCs differentiated into hepatocytes have been used as cell therapy in animal models of inherited metabolic disorders but direct infusion of hepatocytes into the liver is unlikely to achieve polarised bile flow and correct ICDs.Therefore hIPSCs developed from ICD patients will be used to culture hepatocytes on decellularised mou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evaluation of the miscible gas injection in oil reservoirs by monitoring the Asphaltenes concentration' in the context of a Fifth Framework call.

assistant: **Objectives**

The objective of the proposed project is the validation and demonstration of an integrated methodology and tool, which is capable of providing quantitative estimates of the efficiency of gas injection in terms of miscibility in oil reservoirs. Such a tool does not exist today. The methodology is based on the knowledge that asphaltene precipitation occurs during compositional changes when gas is injected into under-saturated oil reservoirs under miscible conditions. Variation in the concentration of asphaltenes measured during oil production will therefore give qualitative estimates of the degree of the miscibility of the injected gas.The integration of these data into the reservoir simulation will quantify these estimates and will pinpoint the areas where the gas has gone into solution or not. In this way the tool will provide field-wide valuable information on to what extent the injected gas has contacted and mobilised the oil in the reservoir.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling' in the context of a Horizon 2020 call.

assistant: **Objectives**

G protein coupled receptors (GPCRs) are a class of membrane receptors that transmits extracellular signals into the cell. They can be activated by a diverse set of ligands including small molecules, hormones, neurotransmitters or photons and are targeted by a third of currently marketed drugs. Endogenous ligands and drugs may exhibit different efficacy profiles, ranging from full activation to complete inactivation of a signalling pathway. The key to the selective interaction with signalling partners in response to ligand binding lies in the conformational flexibility of the membrane receptors. Previous research has extensively studied the three-dimensional structures of GPCRs and their signalling. However, the link between active conformations and signalling is still missing.In the proposed project, first I will use exhaustive single-point mutagenesis coupled to functional assays to determine how the sequence and secondary structure of GPCRs contribute to signaling. Second, biophysical techniques studying protein conformations  will help us to understand the connection between conformations and signalling outcome. These techniques give insights into the conformational fingerprints of the receptor. The link to signalling will be achieved by biasing the receptor towards a selected signalling partner either though addition of the selected signalling partner or the insertion of specific mutations tested in the first part of the project. Finally, I will use computational techniques to compare the activation of signalling partners in different GPCRs.With my research I hope to improve our understanding of the molecular basis of membrane protein function and contribute to the development of strategies for the design of more specific drugs with fewer side effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lusi: a unique natural laboratory for multidisciplinary studies of focussed fluid flow in sedimentary basins' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The 29th of May 2006 several gas and mud eruption sites suddenly appeared along a fault in the NE of Java, Indonesia. Within weeks several villages were submerged by boiling mud. The most prominent eruption site was named Lusi. To date Lusi is still active and has forced 50.000 people to be evacuated and an area of more than 7 km2 is covered by mud. The social impact of the eruption and its spectacular dimensions still attract the attention of international media. Since 2006 I have completed four expeditions to Indonesia and initiated quantitative and experimental studies leading to the publication of two papers focussing on the plumbing system and the mechanisms of the Lusi eruption. However still many unanswered questions remain. What lies beneath Lusi? Is Lusi a mud volcano or part of a larger hydrothermal system? What are the mechanisms triggering the eruption? How long will the eruption last?LUSI LAB is an ambitious project that aims to answer these questions and to perform a multidisciplinary study using Lusi as a unique natural laboratory. Due to its relatively easy accessibility, the geological setting, and the vast scale, the Lusi eruption represents an unprecedented opportunity to study and learn from an ongoing active eruptive system. The results will be crucial for understanding focused fluid flow systems in other sedimentary basins world-wide, and to unravel issues related to geohazards and palaeoclimate aspects. The project will use multisensory sampling devices within the active feeder channel and a remote-controlled raft and flying device to access and sample the crater and the erupted gases. UV-gas camera imaging to measure the rate and composition of the erupted gases will be coupled with a network of seismometers to evaluate the impact that seismicity