RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Stereocontrol in Antibiotic-producing Multienzyme Polyketide Synthases'.

assistant: **Concept**

Many valuable drugs, including antibiotics, immunosuppressants and anticancer compounds are polyketide natural products of actinomycete bacteria. They are produced on modular polyketide synthases (PKSs), assembly-line multienzymes containing many different enzyme active sites, housed in giant multifunctional polypeptides. A number of strategies are now used to engineer PKSs and produce altered bioactive products, especially domain and module swapping between natural PKSs.However, many hybrid PKSs have compromised catalytic abilities. We intend here to use novel knowledge-based engineering of the active sites of enoylreductase (ER) domains, which play a key role in establishing the stereochemistry of branching alkyl groups. We propose that alteration of only a few active site residues will be sufficient to switch the stereochemical outcome of reduction. This hypothesis will be tested using two complementary approaches: (a) individual recombinant ER domains (and site-directed mutants) will be purified and their activity and stereospecificity studied in vitro; and (b) a triketide synthase model PKS will be used to assay altered ER domains in vivo. Finally, the technique will be applied to creating a designed change in the clinically important macrolide antibotic erythromycin A, by switching the active site of the ER domain from module 4 of the erythromycin-producing PKS.This project will comprise an advanced training programme in the techniques and skills to be used in studying unique assembly-line" multienzyme complexes, in which the host laboratory is highly experienced. This will complement the Marie-Curie Fellow's strong existing training in bio-organic chemistry, and thus consolidate and broaden her career prospects, as well as maintaining excellence in European resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'flight demonstration of a Liquid HYdrogen load-bearing tank in an unmanned cargo platform' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The fLHYing tank project aims to flight-test a 1,000-liter flight-load-bearing vacuum-insulated composite LH2 tank in the Pipistrel Nuuva V300 cargo UAV. This project proposal is disruptive in several perspectives: (i) definition of requirements, design, manufacturing and qualification of a relevant-scale flight-load-bearing fully composite liquid hydrogen tank, (ii) accelerated acquisition of knowledge via flight-testing low-TRL hazardous technologies using UAVs, and (iii) effective application of the knowledge via calibration of a fluid-dynamic, thermal and structural digital twin of a composite LH2 tank using flight test data for advancement towards digitalized certification of aeronautical technologies.The fLHYing tank project covers the disruptive maturation of lightweight liquid hydrogen storage systems via the accelerated acquisition of knowledge on flight operation of LH2 tanks, as required by the demonstrator strategy of the Clean Aviation Strategic Research and Innovation Agenda.The main impact of the fLHYing tank project is the unprecedented reduction in the time-to-market of revolutionary technologies in the aeronautical industry, thanks to the ground-breaking fast-track flight testing of a relevant-scale composite LH2 storage system using a UAV, achieving comprehensive understanding of the behaviour of LH2 tanks in the flight environment within minimum timeframe, risk, and cost. This ambitious goal can be achieved within the 1st phase of the Clean Aviation Programme thanks to the fLHYing tank project.


**Keywords:** Liquid hydrogen, Composite, Material screening, Flight-load-bearing tank, Hydrogen peripherals, Ground qualification, Flight testing, UAV, Digital twin, Validation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Electroweak Symmetry Breaking, Flavor and DarkMatter: One Solution for Three Mysteries' (DAMESYFLA) under Seventh Framework.

assistant: **Objectives**

In the next five years, experiments will give us a unique opportunity to unravel the mysteries of Electroweak Symmetry Breaking, Flavor and Dark Matter. The LHC at CERN will push the Energy frontier well into the TeV region and shed light on electroweak symmetry breaking. The LHCb experiment,  super-B factories and other dedicated experiments, also in the lepton sector, will push forward the Intensity frontier and test the Standard Model description of flavor and CP violation with unprecedented accuracy.  Earth- and space-based experiments will push forward the Astroparticle frontier, in particular direct and indirect searches for Dark Matter. My goal is to identify a coherent explanation of the three mysteries, as complete and as unique as possible, by combining the vast information coming from the Energy, Intensity and  Astroparticle frontiers. This requires a global strategy, making use of highly qualified competences in the relevant branches of theory and phenomenology. I will put together some of the leading particle theorists operating in SISSA, Padua and Rome into a unique and extraordinarily strong team. The variety of competences,  ranging from phenomenological fits and data interpretation to unified models and fundamental theories, will be used to interpret the results coming from a wide range of experiments and to formulate a coherent framework to account for them. With the essential contribution of the researchers paid on the project funds, the project will catalyze results going much beyond what the team members could individually achieve. The main support requested to the ERC is for hiring six experienced researchers, the rest of the funds are for optimizing the effectiveness of the team and the research environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Environmental friendly and cost-effective technology for coating removal' (EFTCOR) targeting Fifth Framework.

assistant: **Abstract**

EFTCoR pursuits the development of a new industrial technology for hull coating removal to be applied for ships maintenance. Present technology, grit blasting, is very pollutant and it is progressively being forbidden in most environmental sensitive European countries. Coating removal technologies must satisfy the requirements specified by most of ship owners (quality of the steel surface -SA2 1/2, SA2-). A considerable effort will be put on environmental care, concerning waste separation and disposal, coating removal material recycling, and use of less pollutant paints. To improve the working conditions and reduce vessel operation costs the cleaning process will be automated (substitution of manual tasks by a family of coating removal systems capable of working in a cooperative way).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultimate Angular Resolution Astrophysics with kernel-phase and full-aperture interferometry' (KERNEL) targeting Horizon 2020.

assistant: **Abstract**

Astronomy requires large telescopes to improve the sensitivity and the angular resolution of its observations. Of these qualities, angular resolution is the most difficult to maintain in the optical and near-infrared, since the atmosphere reduces it to that of a 10 cm aperture, regardless of the telescope size. On the one-hand, Adaptive Optics (AO) actively compensates for this effect but the improvement is often partial only. On the other hand, interferometric techniques (most notably sparse aperture masking interferometry) passively allow the extraction of self-calibrating observables, that boost the angular resolution, but severely affect the sensitivity of observations. A framework newly established by the PI of the proposal however now makes it possible to extract generalized self-calibrating observables called kernel-phases from conventional AO-corrected images. The work outlined in this proposal will make it possible to scientifically exploit the high angular resolution imaging capability of this technique, to improve its robustness and to expand its capabilities. The framework offers a very general purpose high angular resolution imaging tool for astronomers as well as wavefront control experts. This proposal is organized in five work-packages of increasing challenge that include: the reinterpretation of existing archival datawith a super-resolution capability, the expansion of its robustness to open up new more challenging use-cases, a special focus on the development of a very high-dynamic range mode, the adaptation of interferometric image reconstruction techniques, and the development of new advanced AO concepts. The consequences of this project will have a major impact on the design and scientific exploitation of future high angular resolution instrumentati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanostructured dielectric platforms for electric and magnetic field-enhanced spectroscopies and nonlinear photonics with low-loss characteristics' to be submitted under Horizon 2020.

assistant: **Abstract**

It is widely known that metals, such as gold and silver, when suitably structured at the nanometre scale, are able to focus light into very small (sub-wavelength) volumes, greatly enhancing its local intensity. For this unique capability such metallic nanostructures are often referred to as “nanoantennas”. In the last decade, metallic nanoantennas have opened up a wide range of applications in numerous fields, spanning (bio)imaging and sensing to the development of optoelectronic hybrid devices. However, since the mechanism of light confinement relies on the collective oscillation of free electrons, generation of heat via Joule dissipation is inherent to the process and detrimental effects arise for several uses, such as surface-enhanced spectroscopies and nonlinear optics.The central objective of this project is to circumvent this issue through the use of dielectric nanoantennas made of silicon or germanium, which have been proposed recently as low-loss alternatives with relatively high field enhancement capability. Specifically, this research will determine, for the first time, the ability of the dielectric nanoantenna to selectively enhance a molecule’s electric and magnetic dipole emmisions, without perturbing the sample by undesired heating. Furthermore, this project will investigate the coupling of dielectric resonators to suitable nanomaterials for high-efficiency infrared-to-visible light conversion, and will design hybrid arrangements of dielectric and metallic nanostructures to combine the best of both worlds. Finally, dielectric metamaterials will be studied for both enhanced spectroscopies and nonlinear photonics to further improve these characteristics. The results of this work will have significant impact in a number of fields and will represent, for the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advanced conformal radiotherapy - stereotactic radiotherapy and intensity modulated radiotherapy' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Three dimensional Conformal Radiotherapy (3DCRT), in which the high dose volume matches as closely as possible the target volume and avoids normal tissue irradiation, has been a major theme in radiotherapy for improving the therapeutic window. More recent and advanced forms of 3DCRT are intensity modulated radiotherapy (IMRT) and stereotactic radiotherapy (SRT). While in conventional 3DCRT geometric field shaping alone is applied IMRT uses additionally the variation of primary beam intensities to achieve a new class of conformation. Stereotactic (SRT), on the other hand, is based on a 3-D stereotactic coordinate system correlated with the patient and the treatment facility through modern imaging technology. Both IMRT and SRT deal with high dose gradients, small fields, require a high dosimetric and geometric precision, and detailed knowledge of the patient anatomy. The training site, located at the Dept. of Radiotherapy and Radiobiology, AKH Vienna, Univ. Vienna Medical School, performs research in 3DCRT since many years. In October 2000 there is even available a linear accelerator dedicated to SRT and IMRT. The training site offers the following research subjects:1. Treatment plan optimization and class solutions for(i) IMRT of prostate and cervical cancer, and(ii) extra cranial SRT of liver and lung tumors,2. Quality assurance of the treatment planning system,3. impact of multi-modality imaging on target definition,4. patient immobilization and respiration control,5. Impact of IMRT on SRT of uveal melanomas. As there is close collaboration with foreign Universities and manufacturer (as a beta test site) there is mulitcentre experience and access to dedicated high tech and state of the art equipment for advanced 3DCRT. Research fellows can participate in programs for f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Novel ICT Assistant Solution for de-Risked Management of Insulin Dosing and Blood Glucose Levels in Hospitalized Patients with Type 2 Diabetes' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite being responsible for up to 1/3 of admissions, the management of type 2 diabetes in hospital wards is still extremely challenging. European clinical guidelines recommend prescription of ""basal-bolus insulin therapy"" as it is the most flexible, adaptable and precise regimen available to mimic the physiological secretion of insulin. However, it requires a patient-centric approach with multiple daily follow-ups. Since both persistent hypoglycemia (due to incorrect medication) and hyperglycemia (due to disease) are hazardous, diabetic care requires day-to-day decisions combining medical judgment and clinical findings. This overwhelming task is even more complicated due to the current inefficient methods that rely on by-hand calculations and paper-based charts. Thus, management becomes a complex task, increasing the workload for the already saturated personnel. Most importantly, it increases the overall risk of medical errors. Indeed, 42% in-hospital days are impacted by treatment errors, wrong blood glucose measurements or lack of adjustments on insulin dosing. Thus, +50% of patients suffer at least one medication error during their stay. In response, we have created GlucoTab, an ICT-based software able to assist on the arduous decision-making process daily incurred in the management of type 2 diabetes. GlucoTab will automate and standardize task management, reducing risks, costs and easing the personnel's work-flow. Conceived as a medical device, our product is able to offer guidance on the most suitable insulin dosing regimen for a patient. By enabling the full integration of the patient's bedside management with the general hospital information system, we believe that GlucoTab encloses a cost-efficient solution that will allow hospitals and healthcare systems t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Secure and Trustworthy Composite Services' to be submitted under Seventh Framework.

assistant: **Abstract**

The Future Internet will provide an environment in which a diverse range of services are offered by a diverse range of suppliers, and users are likely to unknowingly invoke underlying services in a dynamic and ad hoc manner. Moving from today's static services, we will see service consumers that transparently mix and match service components depending on service availability, quality, price and security attributes. Thus, the applications end users see may be composed of multiple services from many different providers, and the end user may have little in the way of guarantee that a particular service or service supplier will actually offer the security claimed.<br/>ANIKETOS will help establish and maintain trustworthiness and secure behaviour in a constantly changing service environment. The project will align existing and develop new technology, methods, tools and security services that support the design-time creation and run-time dynamic behaviour of composite services, addressing service developers, service providers and service end users.<br/>ANIKETOS will provide methods for analysing, solving, and sharing information on how new threats and vulnerabilities can be mitigated. A platform will be constructed for creating and maintaining secure and trusted composite services. Specifications, best practices, standards and certification work related to security and trust of composite services will be promoted for inclusion in European reference architectures. Our approach to achieving trustworthiness and security of adaptive services will take account of socio-technical aspects as well as basic technical issues.<br/>The consortium consists of large industrial and research players in the field, including end user partners with specific domain competence related to three ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Optimisation of screening and cleaning technology to control deinking pulp cleanliness'.

assistant: **Concept**

The project aims at improving the technology in paper recycling to solve critical stickiest" problems related to adhesive entering the drinking process. The approach is to optimise the adhesive size and shape at the pulping step in order to remove them completely by pressure screening and centrifugal cleaning. The basic mechanisms of pulping and fundamentals of screening hydrodynamics including numerical flow simulation will be studied with respect to the theological properties of adhesives. New pulping, screening and cleaning technology will be developed. Flotation and a new pressure filtration technology will be studied to clean further the pulp and the process waters. Optimised strategies for the removal of stickiest in drinking lines and basic knowledge towards recycling friendly adhesives will be established."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evolved Replication Systems for Epigenetics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cells have a broad functional and morphological diversity due to differential gene expression. Research in epigenetics combines the study of inheritable, phenotypical changes in the gene expression pattern of a specific cell type that are not caused by a transformed nucleotide sequence of the genetic code itself. Epigenetic marks are represented by a variety of molecular mechanisms including DNA methylation. Alterations of DNA methylation play a crucial role in the onset of diseases like cancer. Many DNA methylation-based biomarkers have been evaluated and the analysis of epigenetic alterations is a promising tool for disease diagnostics, prognostics, and prediction of drug response. In future, this will allow to adapt therapies to a person, which will increase the chance for successful treatments, minimizing side-effects of chemotherapy and administration of ineffective drugs and thus, prevent the onset of follow-up problems that are associated with these events. Thus, cost-effective but robust means that allow the analysis of DNA methylation-based biomarkers are of urgent need. Several methods for analysis of these biomarkers are employed. However, those that have the required resolution are laborious, time-consuming, and error-prone and thus, prevent broad applications of DNA methylation profiling in clinical diagnostics. The aim of this project is to overcome the barriers that prohibit using DNA methylation profiling in broad clinical applications for diagnostics, prognostics, and prediction of drug response. The objectives will be reached by a multidisciplinary systemic approach harnessing the power of organic synthesis (i.e. new synthetic modified nucleotides), biochemical and structural enzyme studies, and directed evolution of DNA polymerases tailored for new re