RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'G20 Legitimacy and Policymaking'.

assistant: **Objectives**

This project will examine whether the shift in global economic policymaking from the G7 to the G20 has increased its democratic legitimacy and ability to accommodate discontent with economic globalisation. More specifically, I ask how we can explain the relation between more inclusive inputs to policymaking and its outcomes in terms of global financial governance. Ten years following the shift to the G20 and with a full policy cycle behind us, this question can be answered through a multi-methods approach of semi-structured elite interviews - made possible through my years as an international policymaker at the European Central Bank - and network analysis. The interviews will complement an existing set of over 150 elite interviews, paving the way for longitudinal analysis. With support from the Data Archiving and Networked Services centre, these interviews will form a uniquely comprehensive database durably accessible to researchers. My main proposition is that the dynamics of ‘club governance’ hamper substantive change as new members are socialized into conforming to patterns of groupthink. Nevertheless, policy changes can materialize if new topics enter the agenda framed within the boundaries of the existing ideational consensus. The strength of the existing consensus on any given subject should therefore predict to what extent the more democratic policymaking process is reflected in policy outputs.  The Sheffield Methods Institute will provide expert training in qualitative analysis. The host, SPERI, is home to established academics working on similar topics, while supervisor Professor Andrew Baker has unique expertise on G-group policy forums. This institutional fit will ensure my further development as a scholar.  This policy-relevant project will contribute to Int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Feasibility study for registration of medicine RIGVIR with the European Medicine Agency' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer is one of the most dangerous life-threatening disorders for humanity of which melanoma is considered to be one ofthe most dangerous and aggressive. There are a number of therapies available to treat melanoma. However, thesetreatments are generally marginally effective and very expensive.Latima SIA develops and produces Rigvir® for virotherapy. Rigvir® is a unique anti-cancer medicine using non-pathogenicvirus. It has been demonstrated to be very effective in treating various cancers, and has a promising medical future .RIGVIR is commercialised in Latvia, Georgia and Armenia. Rigvir® was approved and registered in Latvia in 2004 and has since been a front-line treatment for melanoma in Latvia. However,further use and commercialisation in the EU is prevented as EU regulations require cancer medicines to be registered centrally through the European Medicine Agency (EMA). National registrations are not considered. Therefore, the process for European Union registration must be started de novo.Registration of a medicinal product requires significant costs and resources. The purpose of this H2020-SMEInst-2016-2017application is to secure the financial support for an initial feasibility study that would provide the basis for subsequent clinicaltrials necessary for the registration of Rigvir® with the EMA.It is expected that after feasibility study we would continue with next phase of H2020-SMEInst-2016-2017 and perform theclinical trials necessary for registration in EMA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hierarchical Optimal Energy Management of Electric Vehicles' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

It has been widely recognized that vehicle electrification provides a potential way for the EU to move towards a more decarbonized transport system and sustainable circular economy. To increase the market share of electric vehicles (EVs), control technology plays an indispensable role in improving the overall efficiency of EVs; however, EV control problem is very challenging because EVs exhibit complex dynamics with uncertainties and nonlinearities, and strong physical couplings among different subsystems. The overarching objective of this project is to develop a novel computationally efficient hierarchical adaptive optimal control framework incorporating transportation information and drivers’ habits suitable for energy management of EVs. To enhance the computational power of the framework, an effective fast optimisation method based on quadratic programming (QP), a novel velocity predictor with varying-prediction-horizon calibrator, and a fast MPC controller will be developed and embedded into the hierarchical control framework, so as to achieve multi-objective optimal control targets, i.e. maximum fuel economy, reduction of emissions, improvement of drivability and battery life extension. Moreover, a hardware-in-the-loop (HIL) test platform will be built up for real-time experiments to validate the efficacy of the proposed approaches. The project will contribute to both control theory and applications in EVs with promising extensions to other engineering problems. This project will sufficiently merge the critical information of human, road and vehicle with a hierarchical control framework to facilitate the energy management of EVs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An Efficient Optical Interface between Quantum Dots and Ultracold Atoms' (HYBRIDQUANTSYS), addressing dissemination and exploitation.

assistant: **Impact**

Quantum information science is a new branch of physics that promises to develop information technologies and measurement systems beyond the limits of classical physics.  Physical implementations of quantum information schemes vary widely and include systems as disparate as superconducting circuits and trapped ions.  While significant progress has been made in each platform, each has its own advantages and disadvantages.  A new paradigm is emerging which aims to combine disparate systems to take advantage of each system's strengths while mitigating their weaknesses.  An example of a hybrid quantum system could use single photons to efficiently transfer information and stationary systems (quantum memories) like atoms to store and manipulate it.  Independently, semiconductor quantum dots have emerged as near-ideal sources of single photons while dense gases of neutral atoms have emerged as a leading candidate for quantum memories.  As of yet, these leading technologies have not been integrated, a necessary step towards the development of a distributed quantum network.  Here, we propose to develop an efficient atomic quantum memory specifically designed for use with a quantum dot single photon source.  The experienced researcher, Matthew Rakher, has extensive experience developing quantum dot single photon sources as a graduate student and postdoc in the United States.  The project manager, Philipp Treutlein, has many years of experience with ultracold atomic systems and in particular, the integration of atomic systems with solid-state systems.  The inability to integrate quantum dots and neutral atoms to date is due to the fact that each system requires experimental expertise and a substantial knowledge base that do not strongly overlap.  Given the unique combination of ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Feedback for Small Companies and Firsttimers (FeedS First)' to be submitted under Horizon 2020.

assistant: **Abstract**

The main objective of this project is to test the effects of feedback provided by FFG experts to R&D projects of small companies and first-timers funded in the “General Programme” of the FFG.The “General Programme” (https://www.ffg.at/en/general-programme-further-information) of the Austrian Research Promotion Agency (FFG) is the biggest and longest running R&D funding scheme in Austria. The focus is on providing feedback for small companies and first timers in the FFG, which are funded in the “General Programme”. These types of companies are selected in this experiment because it was pre-assessed that in these cases feedback would be necessary. The feedback will be offered on the technical concept, the business plan and/or the written application. The effects of this feedback should be measured by the quality of the project execution, quality of future proposals and the success of the project outcomes and company. So far feedback is only provided if the application is rejected. No feedback is given in case of a positive evaluation result. Only a contract is issued and sometimes there are conditions included in the contract (e.g. for financing statements). So, although these projects are classified as worth funding (à “good projects”) until now they do not receive any information on how to improve. This is what this INNOSUP-application intends to change: Give also feedback to the “good projects” in order to further improve the quality of the projects (e.g. in terms of technical issues or economic aspects) with the expectation that this feedback enhances business performance.With this experiment FFG wants to test, if giving feedback for small enterprises and enterprises who apply the first time have positive effects on the quality of the project execution, quality of fut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'What drives the RAN translation and why do we get neurodegenerative disease when it goes wrong?' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The short tandem repeats are common in human genome, but their uncontrolled expansions may lead to several inherited disorders. In Prot-RAN project,  I will focus on the expansion of trinucleotide CGG repeats (CGGexp) in the 5’UTR of fragile X mental retardation 1 (FMR1) gene, which causes common neurodegenerative disease, known as fragile X-associated tremor/ataxia syndrome (FXTAS). The pathogenesis of FXTAS remains unclear, and one of the possible mechanisms, the repeat associated non-AUG initiated (RAN) translation, can be shared in majority of microsatellite expansion diseases, as it was already linked to 9 different disorders. In FXTAS, the CGGexp enhances RAN translation from the 5’UTR of FMR1 mRNA, what leads to the production of toxic polyglycine or polyalanine containing proteins. These aberrant products accumulate in nuclear inclusions in the brain of FXTAS patients, impairing the nuclear lamina architecture and leading to neuronal death. The RAN translation mechanism is still not well understood; therefore, in the proposed project I will identify and investigate the role of proteins implicated in RAN translation initiation/elongation. To achieve this goal, I will benefit from the synergy between my long-time experience in mass spectrometry and the expertise of the host lab in RNA biology, and I will bridge cutting-edge proteomics with RNA biology techniques. Briefly, I will employ the CGGexp RNA-targeting pull-down approaches combined with proteomic profiling, RNA mutagenesis, high throughput protein expression analysis and RNA/protein interaction studies in a context of their functional implications. The role of identified proteins will be then verified in other expansion disorders, e.g. Huntington’s disease, giving insight into more global view of the RAN t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coordination and Composability: The Keys to Efficient Memory System Design' (CC-MEM) targeting Horizon 2020.

assistant: **Abstract**

Computer systems today are power limited. As a result, efficiency gains can be translated into performance. Over the past decade we have been so effective at making computation more efficient that we are now at the point where we spend as much energy moving data (from memory to cache to processor) as we do computing the results. And this trend is only becoming worse as we demand more bandwidth for more powerful processors. To improve performance we need to revisit the way we design memory systems from an energy-first perspective, both at the hardware level and by coordinating data movement between hardware and software.CC-MEM will address memory system efficiency by redesigning low-level hardware and high-level hardware/software integration for energy efficiency. The key novelty is in developing a framework for creating efficient memory systems. This framework will enable researchers and designers to compose solutions to different memory system problems (through a shared exchange of metadata) and coordinate them towards high-level system efficiency goals (through a shared policy framework). Central to this framework is a bilateral exchange of metadata and policy between hardware and software components. This novel communication will open new challenges and opportunities for fine-grained optimizations, system-level efficiency metrics, and more effective divisions of responsibility between hardware and software components. CC-MEM will change how researchers and designers approach memory system design from today’s ad hoc development of local solutions to one wherein disparate components can be integrated (composed) and driven (coordinated) by system-level metrics. As a result, we will be able to more intelligently manage data, leading to dramatically lower memory system en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'New photoswitchable materials based on electron transfer process'.

assistant: **Concept**

Design and synthesis of molecular materials whose physical properties can be controlled by external stimuli are of the most advanced research interests. In this project we aim to synthesize and study in-depth a family of molecular compounds with adjustable electronic properties based on an intramolecular electron transfer (ET) mechanism. The ET phenomenon defines two stable states that can be controlled by temperature, light, electric field, pressure or a chemical stimulus and can be used to design new molecular switches.Following an innovative bottom-up approach, we will generate a family of new switches from the association of donor (LFe(CN)x) and acceptor (L’Co(solv)) building blocks. The obtained systems will be then associated within assemblies in order to produce functional networks with specific, sought-after electronic, optical and magnetic properties, such as photo-induced Single-Molecule Magnet behavior. The ET phenomenon has a high potential technological importance since the photo-induced changes in optical and magnetic properties could in principle allow the design of storage devices with exceptional high density.


**Keywords:** Electron transfer, photomagnetism, switchability,  photoinduced single molecule magnet behaviour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Leveraging Single-Cell and spatial multi-Omics to unravel the molecular interPlay bEtween Botrytis cinerea and strawbERRY flowers and fruit' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Botrytis cinerea, a necrotrophic fungus that causes grey mold, poses a significant pre- and post-harvest threat to 1.2 million tonnes of strawberry produced annually in the EU. This pathogen can establish quiescent, asymptomatic infections in strawberry flowers and unripe fruit, which progress to symptomatic infections as the fruit ripens. Despite its importance, the biological and environmental factors that regulate the onset  and termination of B. cinerea quiescence remain poorly understood. In this study, I propose an interdisciplinary approach combining microscopy, molecular biology, and transcriptomics to unravel mechanisms driving quiescent infections and host susceptibility in the B. cinerea-strawberry pathosystem. First, I will use confocal fluorescence microscopy to track B. cinerea infection in strawberry flowers and fruit, visualizing the pathogen’s entry and transition from quiescence to necrotrophic disease. Building on these observations, I will apply single-nucleus and spatial RNA sequencing to profile the transcriptomes of both the pathogen and host at cellular resolution during key phases of infection. The resulting data will be integrated and analyzed using cutting-edge bioinformatic tools to explore cellular diversity in both organisms and identify the host's transcriptional responses during infection, providing new insights into the molecular pathways governing the complex B. cinerea-strawberry interaction. This research pioneers the use of single-nucleus and spatial transcriptomics to study host-pathogen interactions, overcoming challenges in detecting and profiling invading pathogens at the single-cell level, and application to non-model plant species. It leverages my expertise in plant genetics, the host lab’s specialty in molecular interactions,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pharmacological restoration of selective autophagy for the treatment of skeletal disorders' in the context of a Horizon 2020 call.

assistant: **Objectives**

Lysosomal storage disorders (LSDs) are a family of inherited genetic diseases characterized by lysosomal dysfunction, with a consequent block in the degradative capacity of the cell. The skeleton is one of the most affected organs in LSD patients and current therapies are largely ineffective for the treatment of bone and cartilage manifestations.  Thanks to the support of the ERC-starting grant BONEPHAGY we demonstrated that the degradation of the endoplasmic reticulum fragments via lysosome/autophagy pathway (ER-phagy) exerts ER quality control functions that are essential for secretion of procollagens. This process is impaired in LSD chondrocytes and osteoblasts, the cartilage and bone forming cells, respectively and accounts, at least in part, for the skeletal growth retardation observed in LSD mouse models. Prompted by these exciting findings, RE-STORE proposes to develop a novel cell-based integrated screening platform to identify selective ER-phagy inducers to target the skeletal phenotype of LSDs and contribute significantly to their development into innovative therapeutics. The access to proprietary library,  through a collaboration with an industrial partner,  and the set-up of a rapid hit confirmation in disease animal models will allow RE-STORE to establish a complete  drug development pipeline for the selected hits. RE-STORE is an ambitious project that aims to develop an innovative substrate-to-lysosome screening approach for the study of selective autophagy and to identify new therapies for the so-called “ER-storage disorders” characterized by accumulation of misfolded polypeptides in the lumen of the ER.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Supporting publications on Natural Hazards Research'.

assistant: **Innovation**

The proposed project aims basically to provide a set of publications that will be created within the scope of the Eu-Medin initiative and will be used by the stakeholders of research in the field of Natural Hazards.The above mentioned publications include:- A book on the state of the art in the various natural hazards from the research point of view. A wide board of Editors and external experts will collaborate for the preparation of this publication.- English glossaries of terms commonly used to describe concepts and senses used in references of various types of Natural Hazards (Forest fire, Earthquakes, Landslides, Floods, Desertification, Volcanic risk etc).- A publication including a collection of information regarding the initiatives, services and policies of the EC and International organisations to support R&D activity in the field of Natural disasters.Furthermore the envisaged project aims to update the EU-Medin database of metadata, concerning projects results and to ensure the maintenance of the EU-Medin web portal to serve as a web platform of a virtual organisation for supporting the dissemination of R&D results regarding natural disasters and for facilitating the interaction and synergy between research groups and scientists in Europe and worldwide.