RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The manufacturing of a biological tissue: REgeneration of the JOINt by Developmental engineering.' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The general aim of REJOIND is to provide proof-of-principle for the in vitro manufacturing of a growing bone, with a bioartificial growth plate as a “driving engine” at its core. To achieve this, we propose a developmental engineering approach, based on the modular design of in vitro processes consisting of sequential units corresponding to in vivo developmental stages.  These processes follow a gradual and coordinated progression of tissue growth and cell differentiation that leads to organization of cells into intermediate tissue forms. At every step of the developmental engineering process, computational models will be applied, in order to form a  quantitative foundation for every process and to optimize these. After establishment of a manufacturing process of a growth plate, REJOIND will combine this tissue with osteoblasts or articular chondrocytes to build osteochondral tissues or bioartificial joints. Ultimately, REJOIND aims to achieve an autonomous process of in vitro tissue growth allowing guided size expansion. A close interaction between biologists and engineers will make this possible. Pre-clinical applications that will be explored in animal models range from the repair of deep osteochondral defects in a joint surface, to a total joint replacement for small arthritic joints. We expect that a number of these implants will provide a cartilaginous template for bone formation, therefore some will be tested in vivo in appropriate models for healing of long bone defects. In conclusion, REJOIND aims to provide evidence that through the use of developmental engineering, we can build a tissue in vitro, moving the boundary from manufacturing and control at the cellular level to tissue organization and function. This methodology will result in a more reliable in vivo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The balance of ubiquitin conjugation and deconjugation' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Ubiquitin conjugation is one of the most important signaling systems in the eukaryotic cell. Different types of mono- and polyubiquitin chains determine the fate of target proteins by redirecting them for degradation, relocalization or interaction with new partners. The type of ubiquitin modification on any target is determined by the interplay between the conjugating E2/E3 complexes on the one hand and deubiquitinating enzymes on the other. In practice, it is the balance between conjugating and deconjugating systems that determines the result of the various ubiquitination signals. For three different regulatory systems that are critical for correct genome maintenance, we are now in a position to study not just the individual process of conjugation or deconjugation in isolation, but rather, reconstitute the entire reaction on a defined physiological target. These three target systems, histone H2A, PCNA and P53, can be mono-ubiquitinated by a defined E3-ligase, poly-ubiquitinated by a second ligase and deconjugated by defined deubiquitinating enzymes in a reaction that is affected by known allosteric modulators. Our unique collection of tools to study these systems in vitro allows reconstitution of the full reaction, to trap intermediates, and to study their interaction from atomic detail to kinetic reactivity. Using X-ray crystallography of critical intermediates and kinetic analysis of individual reactions by FRET and surface plasmon resonance, we can address how the mono-, poly and deubiquitinating reactions affect each other. By answering mechanistic questions on the relative effect of the forward and backward reaction components and their modulators we will provide a solid basis for drug design studies that target these pathways against cancer development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerating Neuromuscular Treatment Selection' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Neuromuscular disorders (NMDs) affect an estimated 300.000 people in Europe and no therapies are available for these highly incapacitating and lethal disorders. In the last few years, this status quo has shifted dramatically with the appearance of new RNA therapies targeting several of these disorders. Several clinical trials are currently underway but future development is being slowed due to several motives, mainly related to the requirement of personalised approaches for rarer mutations and to technical difficulties to evaluate the effects of these new therapies on relevant biological outcome measures.I have been awarded a fellowship to develop a platform to streamline drug development for NMDs by combining several resources: immortalized control and patients’ cells, specific antibodies and new imaging techniques to be able to measure immunostained cultured cells directly in plate format. Duchenne muscular dystrophy (DMD) will be the first NMD that will benefit from this approach. Several therapeutic approaches aim to restore dystrophin expression in DMD: gene therapy, stem cell therapy, nonsense mutation read-through and redirection of splicing with antisense oligonucleotides (AOs). A reliable quantitative method to measure dystrophin in cell culture is not yet available and this project will develop such system, which will not only speed up development of new AOs targeting less common mutations, but also be the stepping stone that we will use to expand the platform not only to find treatments to other NMDs, but also possibly as a diagnostic tool for some of them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Personalised Health cognitive assistance for RehAbilitation SystEm' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Stroke-caused cognitive and neuromotor impairment is currently an increasing burden: post-stroke deficits are commonly believed to be treated with rehabilitation. Direct medical costs of stroke are stimated to increase up to 94.3 billion USD only in US. The indirect costs, including non-healthcare costs, are estimated at 15.9 billion. The journey towards recovery includes several stages, from hospitalization to in-patient and out-patient rehabilitation and the subsequent return to home. Not everyone has access to rehabilitation programs, and the gains of them tend to deteriorate after hospital discharge. Focused stroke rehabilitation reduces long-term disability and the economic burden of stroke and supports prevention by lessening modifiable risks. The objective of PHRASE (Personalised Health cognitive assistance for RehAbilitation SystEm) is to create a workflow that integrates the best available scientific knowledge and obtain an efficient prognosis and intervention protocols for stroke and other brain-related diseases. It will not only allow to treat stroke-caused impairments better and more efficiently, but also it is a potential treatment for other neurological diseases like dementia, aphasia and PSCI, depression or multiple sclerosis. Eodyne's PHRASE will be based on RGS previous technology, developing its Technology Readiness Level. The present consortium brings together a comprehensive group of highly qualified experts. So that Eodyne can successfully produce prognosis and intervention individualized protocols, EBRAINS will be the brain database and Charité will provide with its brain models for the combination of data brain. SPECS-Lab will bring its knowledge in cognitive rehabilitation and will act as clinical coordinator, while  Saddlepoint Science brings th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Thalamic sensory processing during different behaviours' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Sensory information is actively acquired and processed in the brain. This is particularly evident in the rodent whisker sensorimotor pathway, where the animal actively moves its whiskers back and forth during exploratory tactile behaviour. Sensory processing in the somatosensory neocortex has been shown to depend strongly upon ongoing behaviour. This state-dependent activity might arise through specific modulation of cortical activity or the differences in sensory processing might relate to changes earlier in the sensory network. In order to investigate this, we need to understand what changes occur in the somatosensory thalamic nuclei, through which sensory inputs transit to the barrel cortex. Here we propose to make whole-cell recordings from neurons in the somatosensory thalamic nuclei in the behaving mouse to investigate changes in spontaneous membrane potential dynamics and sensory processing during different behaviours. Our experiments will focus on uncovering the differential roles of the somatosensory thalamic nuclei in processing sensory information and how they are influenced by different behaviours. Of equal important we will investigate the thalamic contribution to the regulation of brain states. These data will shed light on the membrane potential dynamics underlying state-dependent sensory processing providing clear and well-defined data from identified neurons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Scaleable High-Power Output and Low Cost Made-to-Measure Tandem Solar Modules Enabling Specialised PV Applications' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

SolMates aims to provide a novel industrial, scalable technology for producing flexible, durable, made-to-measure, two-terminal CIGSe/perovskite multijunction thin-film PV modules. By optimized matching of narrow bandgap CIGS bottom cells on flexible substrates (steel, polyimide and flexible glass) with high bandgap perovskite top cells, a conversion efficiency higher than 30% (1cm²) will be reached. The focus on roll-to-roll compatible large-area high-rate deposition techniques for both layer systems in combination with the development of in-line quality control units for defect detection will lead to a minimized cell-to-module gap and full industrial scale-up after the project ends. SolMates will demonstrate a 100 cm² flexible, lightweight, durable, encapsulated monolithic interconnected tandem thin-film module with more than 25%. Due to a unique serial interconnection the made-to-measure production of highly-efficient PV modules in respect to shape, size and output voltage based on multijunction solar cells will become a reality. The developed technologies boost the power output of flexible thin-film PV, paving the way for the uptake of long awaited applications such as integrated PV. By exploiting already existing surfaces for solar energy generation, land-use conflicts will be minimized and the total costs for PV can be reduced. The involved, innovation driven SMEs will cooperate with the research partners to facilitate a pathway to mass production, low-cost, roll-to-roll fabrication of SoleMates’ PV technology and strenghten the EU PV value chain. The environmental footprint of the technology, which is inherently low for thin film devices with thin, flexible, lightweight substrates and encapsulation, will be carefully assessed with respect to SolMates' recycling s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Memory-enabled Optical Quantum Simulators'.

assistant: **Concept**

Scientists have recently begun to explore the quantum nature of some marvelous phenomena such as superconductivity and photosynthesis. A clearer understanding could inspire a technological revolution, with the potential for a huge positive impact on the lives of human beings. Unfortunately, complex quantum systems with many-body interactions are hard to investigate theoretically due to their computational complexity. A promising way forward is to assemble and control real quantum systems to predict the behaviour of other quantum systems i.e. quantum simulation. In this document, I present a research proposal in the field of experimental quantum simulation, to be carried out in room-temperature atomic vapour at the University of Oxford. The central objective is to construct and implement the first memory-enabled optical quantum simulator, building on the world-leading broadband memory expertise in Oxford. In this scheme, stationary atomic excitations act as physical sites and flying photons mediate site-to-site interactions. This will be divided into three sub objectives: (1) building a broadband quantum memory and observing interference between flying photons and stationary atomic excitations; (2) simulating photosynthetic complex in a simplified model by means of an all-optical quantum network; (3) realizing a dynamically programmable memory-enabled optical quantum simulator. These all represent important advances in the nascent, multi-disciplinary field of quantum simulation. Through the two main experiments I performed at Jian-Wei Pan's group in China– long-distance free-space teleportation and quantum memory for down-converted entanglement – I have garnered expertise in large-scale quantum networks and quantum light-matter interfaces. I am therefore in a unique posi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Enhancing the content of beneficial fatty acids in beef and improving meat quality for the consumer'.

assistant: **Innovation**

The aim of this project is to improve the quality of life for the EU consumer by developing strategies for the production of beef with improved nutritional value and quality. The content of saturated fat will be decreased while increasing the content of beneficial n-3 polyunsaturated fatty acids and conjugated linoleicacid. The project seeks to exploit more extensive beef production practices with higher forage inputs (grass and clover), which are the primary source of n-3 fatty acids (mainly alpha-lanoline acid; C18:3n-3). Four beef production systems representative of those used in the EU, but varying in level of intensification will be examined. Beef produced will be characterised for fatty acid composition and meat quality, especially flavour. The role of the rumen and post absorption processes in regulating the dietary potential to manipulate the fatty acid composition of beef will be examined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Explore Research from East to West in Austria' under Horizon Europe.

assistant: **Concept**

One of three key focuses of the European Researchers' Nights “exploREsearch” in Austria will be to enhance the understanding and promote current research in the fields of climate and sustainability with a focus on the European Green Deal. The second key focus is citizen science, which is an efficient way to democratise science and to bring the public and science closer together for enhancing both public knowledge as well as understanding of science. Moreover, in order to open up new perspectives of seeing the world, it is more than necessary to understand arts and show the diversity of research in this area. In this context, the third focus of the European Researchers' Night events ""exploREsearch"" will be Arts & Research. Besides, we will also emphasize on the Horizon Europe Missions. For the first time in Austria, the ERNs will be organised in several major cities (Vienna, Salzburg and Innsbruck) at the same time covering Austria from East to West and enabling about a fourth of the Austrian population to directly participate at the events. The events will, on the one hand incorporate on-site formats such as Scientific Booths and Workshops, Science Talks, Science Cafes, Science Slams, the EU-Corner as well as several Social Activities to bring public and science closer together. On the other hand, virtual formats will integrate lectures and workshops as well as a live stream from the on-site stage program for online visitors. Furthermore, the project incorporates a large number of pre-events of which several are dedicated to Researchers at Schools activities. Support for the event and its promotion was stated by Austrian ministries (including also financial support), other public stakeholders, funding agencies and initiatives. The project ""exploREsearch"" integrates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Discovery 09 A night filled with wonder like no other Young scientists, new science, state-of-the-art technology, challenging art, combined with trendy cocktails, surprising performances and top DJs'.

assistant: **Objectives**

Discovery 09 is the fourth ""party night with food for thought"" in Amsterdam organised by the Very Disco Foundation. On 25 September 2009 from 22:00pm-04:00am, the well-known Science Center NEMO will be filled with 1500-2000 young people who enjoy fascinating science, new music, the latest technologies, stimulating art and bright ideas. This is specifically brought to them by members of their own generation in a fresh trendsetting party atmosphere.The general aim of Discovery is to repeatedly show young, passionate and enthusiastic scientist to the public. This display of scientists, especially in a festival and night-time context that the general audience can relate to, helps to create a new and more positive image of the scientist in general, and of young scientists in particular.Discovery 09 will show young scientists to the public. Not only to the visitors of the Researchers' Night itself but, more importantly, to a broad audience through national media attention and awareness campaigns. While around 1500-2000 people will be present at the Researcher's Night itself, a multiple of that number will see, hear or read about young scientists organising a trendy and unique party night.The festivities during the night itself will be a mix combining cutting edge science, public performances by both young and well-known scientists speaking about their passions, an artistic program, and nightlife activities with popular DJ’s, bands, VJ’s and multiple stages.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sensors embedded in non-critical regions of curing composites to monitor distributions of temperature and cure state in complex components' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The proposed research addresses the development of cure and thermal monitoring techniques in the context of manufacture of thermosetting composites parts. Measurements from cure sensors and thermocouples placed in non- critical locations within the curing component will be used to monitor the state of cure in some critical parts of the structure, where the presence of embedded sensors would be unacceptable. A solution procedure of the inverse heat transfer problem will be developed to enable accurate spatial mapping performed using the localised sensor data. Training content (objective, benefit and expected impact) The candidate will complete part of his PhD study through this project. He will gain experience in composites manufacture by autoclave and resin transfer moulding (RTM) routes. He will acquire knowledge of specialist theoretical tools, fitting him directly for future employment as a modelling-monitoring expert in the composites industry. Links with industry / industrial relevance The host group collaborates with British Aerospace plc. and Short Brothers plc. on projects concerning the application of dielectric cure monitoring in composites manufacturing. This link, plus a close relationship with INASCO HELLAS (Dr. George Maistros is a Technical Director of INASCO and Visiting Fellow of Cranfield University), will ensure industrial relevance at all stages of the development.