RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Genetic Models of Chronic Neuronal Degeneration Causing Hereditary Spastic Paraplegia'.

assistant: **Innovation**

Neurodegenerative disorders, a heterogeneous group of chronic progressive diseases, are among the most puzzling and devastating diseases in medicine. Indeed they are characterized by onset in adult life, distinct clinical phenotypes, and specific degeneration of subsets of neurons and axons. Hereditary spastic paraplegia (HSP) is a disorder that results in progressive weakness and spasticity of the lower limbs affecting approximately 1 in 10000 individuals. Heterogeneity characterizes HSP in both clinical and genetic aspects. Little is known about the pathogenesis of HSP and consequently no specific treatment is available to prevent, cure or delay progression of symptoms of HSP. Electrophysiological and pathological findings point to the corticospinal, dorsal columns and spinocerebellar fibers as the structures primarily affected by HSP. Two main pathogenetic hypotheses for the neurodegeneration seen in HSP, as well as other neurodegenerative conditions, have recently emerged, suggesting that impaired mitochondrial function and/or defective subcellular transportation mechanics play a crucial role. In fact, HSP-causing mutations have been found in gene products involved in mitochondrial function, such as paraplegin and HSP60, and axonal trafficking, such as kinesin and, possibly, spastin and spartin. This consortium of European groups intends to provide a multi-faceted comprehensive approach to study pathogenesis of HSP with a particular emphasis on the role of mitochondrial dysfunction and impaired axonal transport, through the production and characterization of six novel mouse models for this disease, in parallel with the recently developed paraplegin null mutant. The proposed strategy is a highly integrated effort to study the function of several HSP genes, with the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Determinants of mandibular form during intra-oral food processing' (MACACA).

assistant: **Concept**

Whilst the biomechanical determinants of a chewing cycle are essential components of the primate feeding system from an evolutionary and a clinical perspective, lack of experimental studies have resulted in the construction of oversimplified and biologically inconsistent computer simulation models. Such models have been employed to answer hypotheses regarding feeding biomechanics and dietary ecology of extinct and extant species, leading to questionable results. This study applies the most complete bone strain, bite force, jaw optico-kinematic, and electromyographic data to a series of finite element models of a M. mulatta mandible to simulate a complete chewing cycle. The main objective is to estimate stress and strain concentrations on the mandible during molar, premolar and incisor biting when processing food particles that vary in their material properties. The accuracy of the FE models will be tested by conducting a series of sensitivity analyses regarding bite locations. The models will then be validated against experimental in vivo bone strain data. A series of statistical analyses will be also employed to study strain magnitudes and orientations in the primate mandible in relation to loading and unloading times, chewing rates, chewing frequencies and gapes. It is hypothesised that strain magnitudes, patterns and orientations will be highly sensitive to different biting cases and dependent on the food particles consumed and the chewing frequencies employed. The results will give new insights into the nature of the stresses and strains the primate mandible undergoes during a chewing cycle and will indicate how strong the mandible is in relation to the functional stresses it experiences. We will then, with unprecedented rigour, illuminate a level of mechanistic exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular architecture of heteromeric kainate receptor complexes' (KARhet) under Horizon 2020.

assistant: **Objectives**

Kainate receptors (KARs) are glutamate-gated ion channels (iGluRs) known as neuronal circuit modulators. Because of their involvement in epilepsy and mood disorders, they represent an important pharmacological target. Over the past decade, we have learned a lot about synaptic KARs, but their assembly, function and pharmacology remain elusive compared to the closely-related alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR). During my PhD, I used electrophysiology to study the functional properties of KARs and AMPARs associated with auxiliary proteins to gain insights into their roles at neuronal synapses.In the proposed research project, I plan to use structural methods such as X-ray crystallography and single-particle cryo-electron microscopy and tomography to address the questions brought by my PhD thesis work. Specifically, I will combine the functional knowledge and skills that I have acquired with the structural expertise of the host laboratory to inquire about the structural assembly of synaptic KARs and especially the interactions between the different KAR subunits and their synaptic binding partners. Combined with the functional analysis of these interactions, this work will provide valuable information for a deeper understanding of synaptic complexes at the molecular level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Cold War Europe Beyond Borders. A Transnational History of Cross-Border Practices in the Alps-Adriatic area from World War II to the present.'.

assistant: **Innovation**

This project aims to rethink the history of Cold War Europe by examining the development of transnational cross-border cooperation from the end of World War II to the present. Overcoming traditional narratives of a clear-cut European separation symbolised by the Berlin Wall, a decentralised analysis of recent European history will show us that the question of a divided continent should be reframed. The final objective is to challenge a dichotomous vision of two separate Europes, “East” and “West”, from a new, border perspective. To this end, a highly qualified team of senior and junior scholars under my guidance will focus on the Alps-Adriatic region, a historical area that is now shared by Austria, Italy, Slovenia and Croatia. This case involves a relatively narrow geographical area but an unusually broad typological range of subjects. During the Cold War it was divided among socialist but non-aligned Yugoslavia, capitalist but neutral Austria, and NATO and EEC member Italy. Its development from the ""southern end"" of the Iron Curtain in 1946 to the ""most open border"" during the Cold War and a precursor to present-day Schengen Europe, represents a paradigmatic case to study an alternative attitude towards borders, frontiers and boundaries. Drawing on Cold War and borderland studies, social history and the history of European integration, which up till now have not found common ground, our innovative conceptual elaboration will demonstrate the interplay between top-down politics and bottom-up initiatives, thus offering a new, and more nuanced history of Cold War Europe from the border perspective. Reconsidering the European past from this transnational angle, both in terms of geographic and methodological perspectives, will allow us to rediscover the human face of Eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'New polymeric anticancer conjugates of agents derived from natural sources'.

assistant: **Concept**

This project will design new polymeric-natural product anticancer agents. Instituto Biomar has identified pyridoacridine alkaloids and 1 ,5-diazaanthraquinones as promising novel anticancer compounds of high potency, but both display problems in vivo; in particular poor solubility and high toxicity . N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer conjugates will be synthesized to improve tumor targeting and increase water solubility. Prof. Duncan's group has experience in the design of polymer therapeutics for tumour specific delivery, and an HPMA copolymer conjugate (PK1) arising from her work is in Phase II of clinical trials. This project wilI have several phases:i) synthesis of pyridoacridine and 1,5-diazaanthraquinone derivatives containing an aliphatic amine group for polymer conjugation (collaboration with Biomar - some derivatives are already available)ii) synthesis and characterization of a library of polymer-drug conjugates (using HPMA copolymers) with tri- and tetrapeptide spacersiii) evaluation of the rate of drug liberation during incubation with isolated lysosomal enzymes in vitro iv) in vitro cytotoxicity v) in vivo pharmacokinetics and pharmacology. The initial biological results will lead to conjugate optimization and further testing. Most important features are appropriate rate of drug release from the conjugate in vitro by the activating lysosomal enzymes and optimal tumour targeting in vivo (the polymer conjugate must have minimal access to potential sites of toxicity). As a conjugate(s) with optimal therapeutic index emerge more detailed studies will be conducted to determine preclinical toxicity and verify mechanism of action at the cellular level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Prioritization of non-coding somatic mutations in cancer' (NOCOSMIC) targeting Seventh Framework.

assistant: **Abstract**

The purpose of this fellowship application is to allow me to achieve research independence in the field of cancer genomics. To achieve this I believe that I need to develop a niche area of expertise and to enhance my research management and dissemination skills. This fellowship would enable me to realize these ambitions through five main objectives: (i) To obtain greater experience in research project management by managing the financial and research aspects of the fellowship, with advice from the Scientist in charge, and by attending career development courses run by the host institution. (ii) To conduct the proposed research project to understand the role of non-coding mutations in cancer.  The consequences of mutations in non-coding regions of the genome are not well understood in comparison to coding sequences. At present, there are no methods available for the prioritization of somatic non-coding variants in tumour genomes. Therefore I propose to develop and validate a method to prioritize non-coding somatic mutations that could contribute to tumourigenesis. My approach will be to use data from multiple tumour genomes to estimate somatic mutations rates across the non-coding genome, adjusting for confounding effects, and to prioritize regions with a high somatic mutation rate and with high evolutionary conservation. My hypothesis is that regions of the genome that are recurrently mutated in tumours and under evolutionary constraint are likely to be functionally relevant in cancer. (iii) To acquire a deeper understanding of the processes involved in genomic evolution by working with the Scientist in Charge. (iv) To develop my dissemination and outreach skills and activities by lecturing, supervising students and engaging with the public. (v) To apply for independent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Non-Contractive Theory of Naive Semantic Properties: Logical Developments and Metaphysical Foundations' (NTNSP).

assistant: **Concept**

NTNSP concerns the logical developments and metaphysical foundations of a theory of naive truth (i.e. a theory validating the unrestricted equivalence between ‘P’ and ‘ ‘P’ is true’) which blocks the semantic paradoxes by restricting the structural rule of contraction. NTNSP’s main aim is to raise such theory to the status of a serious competitor in the debate among naive theories. This will be achieved by meeting four research objectives in progressive order. The theory will first be provided with the necessary technical framework (in particular an algebraic semantics and consistency proof). The theory will then be extended to a theory of naive reference, showing that it affords an innovative solution to the paradoxes of reference. The theory will subsequently be argued to enjoy substantial philosophical advantages over its naive rivals, in particular in its treatment of various conditionals (from one that allows for a definition of logical consequence in terms of naive-truth preservation to one that allows for a smooth treatment of restricted quantification). Finally, the theory will be given solid metaphysical foundations: failure of contraction will be explained in terms of the instability of the states-of-affairs expressed by paradoxical sentences, and failure of distributivity will be justified in terms of an original, global conception of indeterminacy. NTNSP will be carried out in the highly congenial collaborative research environment offered by LOGOS, involving the organisation of a regular research seminar and a final international workshop. NTNSP aims at the publication of papers on all the issues mentioned, plus the preparation of a monograph and of the workshop’s proceedings. NTNSP will consolidate the applicant’s expertise in philosophy of logic, language
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of the new internally-heated diamond-anvil cell for planetary mineral physics:  Application to high-pressure melting of H2O ice' in the context of a Horizon 2020 call.

assistant: **Objectives**

For the past few decades, diamond anvil cell (DAC) has been the most commonly used static high-pressure device toreproduce simultaneous high pressure (P) and temperature (T) conditions of deep planetary interiors. Laser-heated DACachieved P-T conditions corresponding to the centre of the Earth. However, the laser heating system causes largetemperature uncertainties (±10%), which is critical when one tries to understand planetary interiors based on phase relationsof the candidate materials. The major objective of this proposal is therefore, to develop a new heating system for the DACwhich enables us to heat the sample stably and homogeneously. The new design will be based on so-called internally-heated DAC (IHDAC). In an existing IHDAC, a thin metallic heater which is the sample at the same time, provideshomogeneous high temperature. One of the limitations of the existing system is that it is applicable only to the metallicsample. Therefore, (1) we aim to develop a micro-heater configuration which can heat any type of materials, e.g., silicate,oxide, and H2O. We plan to achieve the P-T condition of P = 200 GPa and T = 4000 K. Then (2) we will conduct high-pressure melting experiments on H2O ice. The melting temperature of H2O ice under pressure places important constraintson the structure of Ice Giants such as Uranus and Neptune. Previously reported melting temperatures of H2O show largediscrepancies, one of the major reasons for which is that most of those studies were based on the laser heating with largetemperature uncertainties. Our new IHDAC will offer incontrovertible melting data from homogeneous and stable heating,and therefore it has a great potential to solve the long-standing controversy of the existing melting temperatures. Our newIHDAC will be a conventional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SYNBEE: EXPANDING SYNTHETIC BIOLOGY ENTREPRENEURIAL ECOSYSTEMS' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Synthetic biology is a disruptive technology that enables completely new processes and products for industry, medical applications and food production, it makes the processes and products cheaper and more sustainable. SynBio will renew and challenge many major industries. The estimated overall market to be affected by SynBio exceeds $13 trillion. The global SynBio market is expected to grow from $5.3 billion in 2019 to $18.9 billion by 2024 with a CAGR of 28.8%. Leading European research organizations have a proven scientific record of excellence in the field. However, European science remains largely under-exploited commercially. One impact factor is difficulty to quickly consolidate transdisciplinary teams. Indeed, there is a need for clearer vision on the necessary current and future skills, required by the industry. SynBio is a relatively young discipline, made up of multiple sub-divisions, thus searching for a right profile (KOL, researcher, intern) is time-consuming for industrial companies, and can be even longer for startups. While the boom of accelerators and incubators and entrepreneurial training have driven start-up creation, the lack of specific thematic approaches can hinder the creation and/or maturation of SynBio start-ups. The SYNBEE project will address these challenges by: (i)SWOT analysis, matrix of best practices, mapping of academic profiles and industry in SynBio. (ii)General and SynBio-specific entrepreneurial training in close interaction with the industry.(iii)Networking, matchmaking between candidates and hosting and mentoring industrial partners, hackathons, pitch contests. (iv)Creation of a path from talented student to startup creation and investor workshops.(v)Policy making and mentoring between ecosystems.(vi)Specific focus will be brough
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The interplay of symbiont nutrient release and host phagosome maturation in photosymbiosis regulation' (PhagoPhoRe).

assistant: **Innovation**

Photosymbioses between heterotrophic hosts and phototrophic algal endosymbionts have repeatedly and independently evolved across the tree of life. The immense productivity of photosymbioses affects global nutrient cycles, yet global warming is disrupting these nutrient-exchange symbioses, destabilizing the ecosystems they support. Heat stress erodes the metabolic controls underlying the establishment and maintenance of mutualistic carbon recycling in these symbioses. A link between endosymbiont nutrient release and their intracellular maintenance could thus explain the evolutionary establishment as well as the ecological collapse of photosymbioses in the Anthropocene. Harnessing recent advances in cell isolation and culture techniques, PhagoPhoRe seeks to understand the processes underlying the establishment, maintenance, and breakdown of the cnidarian-algal symbiosis. Specifically, I will investigate the idea that the release of photosynthates enables algal endosymbionts to evade phagosomal digestion and autophagic immune responses of the host by mimicking ongoing digestion processes. In three complementary work packages that combine state-of-the-art single-cell transcriptomics, proteomics, and isotopic imaging techniques, I will: 1) Characterize the role of host phagosome maturation processes in the intracellular establishment and maintenance of algal endosymbionts. 2) Investigate the postulated link between algal nutrient release and host phagosome arrest and immune suppression. 3) Examine the drivers of co-evolution towards obligate metabolic interactions in photosymbioses. Deciphering the interplay between symbiotic nutrient cycling and host phagosome maturation will be key to understanding the establishment and subsequent breakdown of photosymbioses. These process