RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The develoment of analytical procedures for medical and bilogical material using the Multiple Internal Reflection Assay""' (MIRA-SYSTEMANALYTIC).

assistant: **Concept**

In material from living organisms it is necessary to detect and quantify substances in very low concentrations. The analytical procedures are time consuming and tedious. Medical and biological laboratories will use faster and combined analyses with advantage. It is the aim of this project to develop a quick measuring device for more than one parameter at a time. This will be achieved by the use of capillarys instead of cuvettes or else: by using the wall of a capillary as guidance for lignt, fluorescent molecules can be measured at the inner wall side due to the evanescent waves". If the wall is coated with an antigen for example, then a competitive binding of antibodies is possible. By adding a known amount it is possible to calculate the unlabelled amount present. This is called the Multiple Internal Reflection Assay (MIRA). This has been tested in principle, and patents have been granted in Europe and USA. The market of immunoassays is great. In future a growing market for DNA/RNA or cell compartments is expected. Producing a system which works more time and cost-effective will have good chances on the European market and also chances for the SME's to get market positions."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel cancer vaccines with virus based cDNA libraries and monitoring for resistant tumour cell populations in prostate cancer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Prostate cancer is a huge burden of disease in Europe and the world and patients frequently relapse after initial attempts at the cure of localised disease.  Cancer vaccination has activity but is only moderately effective.  My ERC Advanced Award will use novel translational approaches to take a  highly novel vaccine strategy which is excellent in mouse models towards a clinical vaccine for prostate cancer patients.We have developed a novel strategy for anti-prostate cancer vaccination based on the expression of cDNA libraries in viral vectors.  Using vesicular stomatitis virus and prostate and melanoma derived libraries, this is curative in mice and we have established its mechanisms and the key antigenic determinants (Nature Medicine, Nature Biotechnology).  We now have to translate this radically new vaccine strategy to the clinic.  My ERC Award will be used to develop the vaccine strategy in an adenovirus vector, optimise viral constructs for optimal immunological effect and evaluate these in mouse prostate cancer and human in vitro immune systems.  I hypothesised that in the clinic, the emergence of resistant populations of tumour cells from heterogeneous human cancers is likely to be a key factor in clinical failure.  We will study resistant and recurrent tumours in mice using immunological and proteomic approaches to tumours and plasma in order to identify potential mechanisms of resistance to the vaccine, and potential blood protein biomarkers of resistance, which will allow us to incorporate strategies to avoid resistance in our clinical programme.  In five years we aim to open phase I clinical trials.The award will fund the essential original translational science to turn the highly novel scientific strategy into a potential clinical strategy.  Work to take th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A platform for Assessing and Bridging Generative AI and Human Skills in Secondary Education' (GenAI4ED), addressing dissemination and exploitation.

assistant: **Impact**

Despite the recent emergence of GenAI and large language models (LLMs), numerous educational tools utilizing these technologies have already been developed, with their numbers expected to increase rapidly. Users of such tools are also growing exponentially. AI-based educational tools, leveraging the capabilities of large language models, usher in a new era of education with personalized tutoring, easy content creation, and automatic grading. As the array of available tools expands, educators must acquire digital competencies to select and evaluate the most suitable options. However, the swift growth in GenAI capabilities raises concerns about their impact on students (e.g., misinformation, increased cheating, ethical and privacy issues) and teachers (reduced social interaction, job displacement, and loss).The GenAI4ED project aims to address these challenges by developing a digital platform to consider popular AI-based educational software, evaluate various aspects of each tool, and offer the most suitable option for individual teachers and/or students. Notably, the platform will be employed in pilot experiments in selected schools, whereby students and educators will be asked to evaluate the available tools. Assessment will be based on a predefined set of carefully designed criteria, exploring how such tools affect the student’s experience and how they complement the teachers’ skills and improve their working conditions. Importantly, through an interdisciplinary approach involving experts in AI, psychology, and ethical concerns as well as teachers and parents, GenAI4ED will utilize the results of the pilot experiments to develop policy recommendations on how to harness the benefits of GenAI tools best to enhance the teaching experience for both students and educators,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Organic and Large Area Electronics' to be submitted under Seventh Framework.

assistant: **Abstract**

Organic & large area electronics (also known as plastic electronics, printed electronics or organic electronics) allows electronic circuits and devices to be produced using relatively low cost printing processes onto any surface, whether rigid or flexible, and over large areas.  It will lead to the creation of whole new generations of products such as conformable and rollable displays, large area efficient lighting, low cost solar cells, low-cost RFIDs and memories, flexible and environmental friendly batteries, and others.<br/>The objectives of this Collaborative Action is as follows:<br/>1.\tTo stimulate the technology and business relationships within the European OLAE community, removing barriers to industrialisation.<br/>2.\tTo contribute to knowledge and technology transfer from lab to fab", thus significantly accelerating the speed of innovation and industrial development of OLAE in Europe<br/>3.\tTo enhance the supply chain, by improving materials and processes and substantially advancing the potential for new business cases in OLAE.<br/>4.\tTo stimulate collaboration between European enterprises, universities and R&D Centres.<br/>OLAE+ aims to consolidate the respective funding activities throughout Europe and achieving the best possible exploitation of the resources and the innovative potential of European industry and science. This shall be achieved through a joint call focussing on OLAE technology, materials, and systems.<br/>The topic and basic concept for this EN+ originate from the Mirror Group of the European Technology Platform Photonics21 which is made up of governmental representatives from the Member and Associated States involved with the promotion of photonics. The topic list was defined in close "concertation" with the OLAE constituency following
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigation of the voltage-dependent anion channel 2 (VDAC2) by solid-state NMR and molecular dynamic simulations'.

assistant: **Concept**

Voltage-dependent anion channels (VDACs) are pore-forming proteins expressed in the outer membrane of eukaryotic mitochondria. The three isoforms of VDAC, i.e., VDAC1, VDAC2 and VDAC3, are known to be expressed ubiquitously in mammalian mitochondria. The individual VDAC isoforms (VDAC1 and VDAC2) are considered to play different roles in the induction of apoptosis through Bcl-2 family proteins and may also play a role in switching apoptotic signaling, whereas the function of VDAC3 is till date not fully known. In particular VDAC2 has been suggested to play a specific role in regulating apoptosis by interacting with, and thereby preventing activation of, the proapoptotic protein BAK. Solid-state NMR (ssNMR) methods will be used to study the structural aspects of VDAC2 and its interactions with apoptotic proteins. These experiments will be performed on isotope-labeled [13C, 15N] protein variants, from which resonance assignments and structural restraints of VDAC2 in lipid bilayers will be obtained. As a complementary method, the molecular simulations (MD) will be performed to study first the homology model on VDAC2 based on the VDAC1 structure, and finally used as the comparison to the ssNMR data. In the MD part the function and interaction mode of the N-terminal helix is of the main interest. In general, the goal of this project is to characterize the structure and dynamics of VDAC2 and to understand its role as an anion channel in the outer mitochondrial membrane in apoptosis and possibly neurodegeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fundamental dynamical processes near massive black holes in galactic nuclei' in the context of a Seventh Framework call.

assistant: **Objectives**

I propose to combine analytical studies and simulations to explore fundamental open questions in the dynamics and statistical mechanics of stars near massive black holes. These directly affect key issues such as the rate of supply of single and binary stars to the black hole, the growth and evolution of single and binary massive black holes and the connections to the evolution of the host galaxy, capture of stars around the black hole, the rate and modes of gravitational wave emission from captured compact objects, stellar tidal heating and destruction, and the emergence of ""exotic"" stellar populations around massive black holes. These processes have immediate observational implications and relevance in view of the huge amounts of data on massive black holes and galactic nuclei coming from earth-bound and space-borne telescopes, from across the electromagnetic spectrum, from cosmic rays, and in the near future also from neutrinos and gravitational waves.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biological resources management and training' under Fifth Framework.

assistant: **Concept**

Description:The DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, is a world class Resource and Research Centre, covering prokaryotes, yeasts, fungi, plant viruses and plant, human and animal cell lines. It contains state-of-the-art equipment and support designed for phenotypic, molecular and chemotaxonomic characterization of prokaryotes needed for their identification and classification. The facility covers aspects of systematics of Prokaryotes, preservation of Archaea and Bacteria, of management of databases, patent-related matters and of issues relating to the acquisition, long-term maintenance, handling, certification and distribution of biological material. The institute is one of the key facilities providing new descriptions of prokaryote species, genera and higher ranks. It offers also access to molecular identification of cell lines, research on leukemia-lymphoma cell lines, genome analysis of plant viruses, cryopreservation of plant cell cultures, as well as molecular analysis of as yet uncultured bacteria. As a MIRCEN institute and strongly embedded in EU-funded projects, the facility has a long and acknowledged experience in training guests from Europe and other parts of the world.Application:The interested user is directed to the home page of the DSMZ (www.dsmz.de) via advertisement in international scientific journals. The cover page of the home page shows a paragraph: Research and Training at a Culture Collection financed by the EC". The interested user is then guided to further information on the profile of the DSMZ and the application forms to the Large Scale Facility.Project Manager:Erko StackebrandtTel: +49-531-2616352Fax: +49-531-2616418E-mail: erko@dsmz.de"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Innovative Midlife Intervention for Dementia deterrence'.

assistant: **Objectives**

The European costs of dementia were estimated €177 billion and there is a growing gap between burden and budget. The debilitation associated with dementia makes it the most feared of conditions related to ageing .Modelling studies have estimated that if obesity rates dropped by 5%, dementia prevalence rates would be lower by 6% and a decline in physical inactivity rate by 5% would reduce dementia by 11%.  For even a very small delay in disease onset of 1 year it is estimated that this would decrease dementia prevalence worldwide by 12 million fewer cases by 2050.The current European road map for the prevention of dementia indicated that prevention needs to start years before symptoms become apparent and needs to be multi-domain focussed.  Dementia has complex and interacting aetiologies including, poor diet, cardiovascular problems, low exercise levels, low cognitive stimulation and mood problems. Clearly these risk factors are shared with many other diseases of ageing and interventions for them already exist around Europe in many cases.This project seeks to design and test a stare of the art electronic system for use in primary care to profile individual’s dementia risks and respond to those risks with a combination of the best available on-line strategies and locally sourced options.  This will be achieved through advanced web search and aggregation technologies.  This will enable comprehensive state of the art assessment, multi-use of programmes already designed for such risk modification, flexibility for the end user, and ease of use for primary care staff.  The intervention is aimed at people in their sixth decade.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Policy Influence of indicators' in the context of a Seventh Framework call.

assistant: **Objectives**

Our overall aim is to help find better ways of using indicators in all aspects of policy, but with a thematic focus on the role of indicators in fostering and supporting change in areas of policy making towards ‘Sustainable Development’. The research area of indicators in the presumed service of sustainability will provide a rich ground for addressing the actual use, influence and impacts of indicators, reflecting dynamic interactions between forces for policy continuation and versus policy change.  . The objectives of the project are to:  Design a coherent framework of analysis and generate hypotheses on the use and influence of indicators, by pulling together the disparate strands of research and practical experience of indicator use and influence, focusing broadly on European policies, but with a special emphasis on fostering change towards sustainability  Test the analytical framework and the hypotheses on specific cases of sector integration and sustainability indicators, as well as composite indicators (indices) in order to  • identify the ways in which indicators influence policy, including the unintended types of influence and situations of ‘non-use’; and • Identify factors that condition the way in which indicators influence policies, including the process and the outcome of designing and producing indicators, the type of indicators, expectations of stakeholders involved, the role of the organisations preparing and disseminating the indicators, as well as general socio-cultural and political background factors.  • Recommend ways to enhance the role of indicators in supporting policies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The SRA domain: a connection between DNA methylation and histone modifications within the epigenetic code? The Arabidopsis VIM family', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Heterochromatin in both mammals and plants is associated with methylation of cytosines within the DNA sequence. While DNA methylation is widespread in plants, fungi, and animals, it has been curiously lost in Saccharomyces cerevisiae, Schizosaccharomyces pombe, Caenorhabditis elegans, and Drosophila. However, the methylation system in Arabidopsis is very similar to that in mammals, showing that DNA methylation is highly conserved, and that Arabidopsis is an excellent model system to study it. DNA methylation is controlled by two different but equally important processes: establishment and maintenance. Two classes of DNA methyltransferases, DNMT3 and DNMT1, respectively, are responsible for them, and are conserved between mammals and plants. Maintenance DNA methyltransferases methylate hemi-methylated sites upon DNA replication, so that the methylated or unmethylated status is inherited on both of the two newly synthesized DNA molecules. Therefore, DNA methylation serves as a marker on genomic DNA that can persist over cell generations. Evidence suggests that methylation DNA is linked to the methylation status of the surrounding histones, a self-reinforcing feedback loop for the maintenance of DNA and histone methylation that may help to explain the remarkable stability of epigenetic silent states. A group of proteins with a methylated DNA-binding domain, the SRA domain, from both Arabidopsis and humans has been recently discovered with a potential role in recognizing hemymethylated DNA and interacting with chromatin remodeling factors. In this proposal, I plan to characterize the role of the Arabidopsis SRA-domain containing proteins family (VIM family) in DNA methylation control, and how this is related with histone acetylation and methylation in a way to regulate gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Disk Instabilities in Highly Accreting Neutron Stars' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Astrophusical accretion disks are the main engine of most of high energy sources. Although they have been studies for decades, we still do not know their exact structure and their evolution with luminosity. A clear example is at high luminosity, for which our best theory predicts the presence in all sources of an instability which leads to the cyclic disruption/rebuilding of the disk. However, from the observational point of view, we have observed only a handful of accreting black holes. My recent work has demonstrated that these instabilities can take place also in accreting neutron stars, opening a new way to study this still poorly understood process. The main objective of DIANA is to exploit the recent advancements in highly accreting binary systems to set the most stringent constrains on the evolution structure of the accretion disk around neutron stars near the Eddington limit. To achieve this, I will combine for the first time X-ray polarization measurements with fast O-IR observations. The synergy of these two groundbreaking techniques will allow me to link directly the variations of the accretion flow structure to the relativistic ejections observed in these systems. Building on these observational results I will develop the first 1-D model for accretion instabilities around accreting neutron stars. This will represent a significant advance in our understanding of accretion disks, as will allow us to compare the appearance in BH and NS, providing key constrains on the origin of instabilities, and informing future 3D global simulations.


**Keywords:** Accretion disks, neutron stars, black holes, jets