RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multifunctional Flat Quantum Sources' under Horizon Europe.

assistant: **Concept**

MultiFlaQS aims to develop efficient multifunctional sources of quantum light, namely entangled photon pairs and triplets, and squeezed states, based on ‘flat’ platforms, i.e., ultrathin layers and metasurfaces. The advantages of flat quantum sources (FlaQS) include: (i) small footprint and integrability; (ii) ultrabroadband and ultrafast operation; (iii) the possibility to combine several functionalities in the same device.Unlike linear and nonlinear ‘flat’ optics, which were developing for almost two decades, FlaQS appeared only recently, and mainly included single-photon sources. A few years ago, also FlaQS of entangled photons emerged; however, their efficiency is low and the advantages of the ‘flat’ geometry are not fully used. Generation of multiphoton quantum states, such as squeezed or graph states, is still a challenge. Most importantly, multifunctional operation has not been demonstrated. MultiFlaQS will make a decisive new step in developing FlaQS, one of paramount importance for quantum photonic technology.The following objectives are set: -Efficient generation of two-photon states and squeezed states, and their use in quantum sensing;-First-time generation of three-photon states through a direct decay of one photon into three;-Implementation of multiple functionalities: generation of quantum states, their frequency conversion and quantum operations on them.  To meet them, the applicant will combine her quantum optics and quantum information expertise, including pioneering steps in developing FlaQS, with recent ideas in nanofabrication design.As a result, engineering of quantum states of light will be brought to a principally new level. Apart from the compactness, integrability, and broadband operation, FlaQS will be multifunctional and combine generation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Lorentz violatining brane-world models and their cosmological relevance'.

assistant: **Objectives**

In recent years, observational evidence for an accelerated expansion of the Universe has triggered investigation of non-conventional cosmological models. At the same time, the precision reached in the observation of the Cosmic Microwave Background Radiation (CMBR) offers the possibility of detecting deviations from the predictions of ordinary models of the Early Universe.In particular, models in which the observed Universe is a four-dimensional surface in a higher dimensional space-time (so called Brane-World models) offer a wide range of possibly interesting new phenomenology. In this context, we investigate scenarios in which Lorentz invariance is violated by the geometry of the higher dimensional space-time. We will study the consequences of this fact on both the early- and late-time cosmological evolution. In particular, we will address the questions whether these type of constructions can accommodate the possibility of a late-time accelerated expansion, whether there can be distinctive signatures of this type of Lorentz-violation in the spectrum of the CMBR, and whether these models provide new string-theoretical realizations of Inflation.We will also explore the consequences of breaking Lorentz invariance from an effective field theoretical point of view. We will address these questions in two kinds of models with different nature of Lorentz violation: in the first class of models Lorentz invariance is broken by the bulk metric; in the second, the bulk metric is Lorentz-invariant but the boundary conditions are not. Within the latter class of models we will focus our study on a recently found time-dependent string theoretical construction. This model is particularly promising for realising inflationary cosmology in string theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Full-scale Innovative integrated Tooling for Composite material Wing-box'.

assistant: **Concept**

FITCoW addresses directly the challenges of AIRFRAME ITD - Reduce aviation environmental footprint through product performance improvements (drag, weight, versatility) and an eco-friendly life cycle including significant recyclability increase as well as optimized material streams applied to the category of 19-pax commuter aircraft. The global objectives presented for the CS2 program are particularized to this project as a reduction in the carbon dioxide emissions of the developed product and associated lifecycle and an increase in the EU competitiveness.FITCoW aims to implement tools that can reduce the recurring costs of low-volume production and, with this, benefit reducing carbon emissions through three different manners: in the manufacturing of the tooling itself as part of the project in comparison of tooling currently used, in the operation of the tooling in the manufacturing of the final aeronautical structures and in the operation of the manufactured aeronautical structures through the developed tooling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TREM2 MICROglia ENGENEering for treating dementiaS (TREM2MICROENGINES)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project TREM2MICROENGINES aims at demonstrating that raising and restoring TREM2 expression in the brain of Alzheimer’s disease (AD) and Nasu–Hakola disease (NHD) patients, and in particular in their microglia, would result in therapeutic benefit.AD is a severe neurodegenerative disorder that represents the most frequent form of dementia among the elderly which affects approximately 5.1 million Americans and this number is supposedly tripled by 2050. AD is believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques. TREM2-Triggering receptor expressed on myeloid cells 2 is a microglia cell-surface receptor whose deficiency or haplo-insufficiency augments Aβ accumulation due to a dysfunctional response of cells, which become apoptotic. Homozygous, loss-of-function mutations in TREM2 also cause the autosomal recessive disorder NHD, a ultra-rare inherited disease of the white matter (WM) with typical onset in the adult age, and patho-physiologically characterized by microglial dysfunction (microgliopathy). The key clinical feature of NHD is progressive presenile dementia usually leading to death in the fifth decade of life NHD patients also lack curative treatments. A relevant proportion of AD cases and all forms of NHD are caused by pathogenic mutations in the Trem2 gene which lead to microglia dysfunction contributing to and/or causing the onset and manifestations of AD and NHD. Based on this provision, our working hypothesis is that transplantation of HSCs engineered by LVs to express robust TREM2 levels in response to tissue damage in CNS-engrafted myeloid/microglia cells would modulate neuroinflammation, restore physiological microglia functions and contribute preventing and reducing Aβ accumulation in the CNS of AD and NHD patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tantalum pentoxide photodeposition on silicon' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The TOPS project aims to establish an excimer lamp assisted photochemical vapour deposition (photo-CVD) process for the fabrication of ultrathin tantalum pentoxide dielectric films on silicon for 0.13 µm ULSI silicon, and will also explore the extension of this process to other novel dielectrics. Photo-CVD will explore the use of high energy ultraviolet photons as an alternative energy source to current high temperature rapid thermal processing. The proposed process route is highly novel and has the potential to lead to significant breakthroughs in ULSI processing.The project will be structured in two phases. Phase 1 will demonstrate the concept of a basic excimer lamp assisted photo-CVD process for the deposition of tantalum pentoxide gate dielectric films. The criterion for success of this phase will be the deposition by photo-CVD of a tantalum pentoxide dielectric on silicon and the preliminary physical and electrical performance characterisation of the dielectric layer thus grown. Phase 2 will address optimisation of the photo-CVD process window on 100 mm wafers in terms of fabrication parameters and substrate surface termination following surface cleaning.Future ULSI CMOS technologies (e.g. critical dimension 0.13 µm) will require gate dielectrics with equivalent silicon dioxide thicknesses in the range 35-50Å, appropriate electrical characteristics and high reliability. One of the most critical challenges for deep submicron silicon research is the technological limit to the use of silicon dioxide as a gate dielectric. For 0.13 µm ULSI CMOS, the projected gate dielectric thicknesses for silicon dioxide become so thin that direct tunnelling effects and excessively high electric fields become serious obstacles to reliability. What is required is a thicker layer of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PREcision medicine Drug combination testing In neuroblastoma organoids to guide Clinical Trials'.

assistant: **Objectives**

Neuroblastoma are pediatric tumors that respond poorly to chemotherapy and have a very poor prognosis. To improve treatment options, a global development towards precision medicine is ongoing. This strongly focusses on molecular genetic target identification in tumors and subsequent assigning patients to the best trials according to their molecular profile. Still it is difficult to predict which patients will benefit from these targeted compounds. In addition, if tumors do respond to single compound targeted therapy, they almost always relapse. These tumor evolution processes could be prevented by simultaneous intervention in different activated tumor pathways.We now want to study how we can select patients that will most likely respond to a targeted compound and what combinations of targeted compounds are most effective? This can’t be tested in a clinical setting since the number of neuroblastoma patients that can be included in Phase1/2 trials is very small. Recent research shows that tumor organoids mimic human tumors and can effectively be used as xenograft in nude mice as well. These in vitro and in vivo models could be used as an alternative selection system for optimal combination treatment in a personalized approach.The overall aim is now to test if combinations of targeted compounds can cause complete remission in neuroblastoma organoid model systems to select combination treatment options for personalized clinical trialsFor this purpose we will generate neuroblastoma organoids that properly represents the complexity and heterogeneity of individual tumors and build a repository that represents the various subtypes of neuroblastoma tumors. We will identify synergistic compound combinations that are effective in neuroblastoma tumors that are characterized by spec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flow measurement for control of pneumatic conveyors and oilfield pipelines', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Flowmeters for pneumatic conveyors and oilfield pipelines will be designed by Process Tomography Ltd (UK) and Fluenta a/s (Norway) who have the following research objectives A Solids Flow in Dense Phase Pneumatic Transport 1. Apply electrical capacitance tomography to measure the solids concentration profile 2. Measure the velocity profile by cross correlation B Oilfield Pipelines 1. Apply Electrical capacitance tomography to determine the flow regime 2. Use the flow regime information to improve the accuracy of an existing oil/gas/water flow meter when used in highly disturbed flows 3. Incorporate a flow regime independent multibeam gamma densitometer using a very low strength source, for gas content measurement 4. Incorporate a new capacitance tomography technique combined with an existing inductive technique to measure the water fraction over a 0-95% range C Both Instruments Incorporate and evaluate state of the art reconstruction algorithms, which are being developed in other programmes. This will overcome the electrical field distortion of the previous generation capacitance sensor. It will enable the flow regime independence to be maintained in the face of wide variations in the electrical properties of the conveyed materials.The result will be new instrumentation for:1. Solids flow measurement and control (transport at minimal energy cost and minimum breakage);2. Flow regime independent oil/gas/water component flow measurement (especially important for exploiting marginal oilfields).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computing infrastructure for the definition, performance testing and implementation of safe-by-design approaches in nanotechnology supply chains' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A major challenge for the global nanotechnology sector is the development of safe and functional engineered nanomaterials (ENMs) and nano-enabled products (NEPs). In this context, the application of the Safe-by-Design (SbD) concept has been adopted recently by the nanosafety community as a means to dampen human health and environmental risks, applying preventive safety measures during the design stage of a facility, process, material or product. However and despite its importance, SbD prescriptions are still in their infancy, and are hampered among other things by the lack of comprehensive data about the performance, hazard and release potential of the great variety of NEPs in use. SbD4Nano addresses that problem creating a comprehensive new e-infrastructure to foster dialogue and collaboration between all actors in the supply chain for a knowledge-driven definition of SbD setups that optimize hazard, technical performance and economic costs. Our project developes a validated rapid hazard profiling module, coupled to a new exposure-driven modelling framework to reduce toxicity. This safe-born material also undergoes a cost-benefit analysis algorithm to find the best compromise between safety and a industrially convenient technical performance. Finally, a new software interface where product information can be exchanged between the supply chain participants is the tool that wraps up, finishing the collaborative spirit of SbD4Nano between regulators, researchers and industry. Coherently with its goals, our SbD4Nano project is international and open-scienced in essence, with the clear aim of impacting the EU policies as well as directly and clearly benefiting the citizen.


**Keywords:** Exposure, Safe-by-design, nano-informatics, data-sharing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Language learning in monolingual and bilingual infants: Evidence from electrophysiological and optical signals' (InfantBilingualBrain).

assistant: **Concept**

Bilingual infants have to deal with two languages at the same time. Some previous studies showed delayed processing in bilinguals due to the higher cognitive load they are faced with. However, other studies show that they master this challenging task with a fascinating ease and at the same pace as monolingual infants. In order to get clearer insights into language learning processing mechanisms in mono- and bilingual infants we will adopt a statistical learning paradigm in which 6 and 18 month old infants listen to phonotactically legal and illegal pseudowords presented in combination with different pseudoobjects. Phonotactics is a prelexical cue relevant for segmentation and lexical access and thus playing a crucial role during word learning. Legal phonotactic rules will correspond to German, whereas illegal rules will correspond to the Slovak language. Monolingual infants will have German as their native language and bilingual infants will be confronted from birth with German and Italian. Thus, the experimental material reflects processing of the native language compared to a foreign language rule. In order to be able to differentiate fine-grained language learning mechanisms we will adopt simultaneously two neuroscientific methods: the electroencephalography (EEG) and the functional near-infrared spectroscopy (fNIRS). The former allows an exquisite temporal resolution aiming at identifying temporal characteristics of fast processing mechanisms and the latter will focus on topographic issues, especially on lateralization. The research questions of the present study focus on whether bilinguals are more flexible learners than monolinguals providing superior learning abilities with respect to a new language or whether a word-object associative learning context provides a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development of a novel genetically engineered mouse model to study the role of HDAC6 in oncogenesis and metastasis of non-small cell lung cancer.'.

assistant: **Concept**

Lung cancer is a leading cause of cancer deaths in Europe. Non small cell lung cancer (NSCLC) accounts for nearly 85% of all cases of lung cancer with a five year survival rate of 15%. Novel targeted therapies are urgently needed to overcome drug resistance and prevent tumour recurrence. The host supervisor carried out a small molecule screen to identify therapeutics for the treatment of drug-resistant NSCLC. A novel specific inhibitor of histone deacetylase 6 (HDAC6) was discovered. The molecular mechanisms of HDAC6's role in cancer is beginning to be elucidated however, this task is made difficult due to the lack of a specific inhibitor. The overall research aim of this proposal is to understand the molecular mechanisms of HDAC6 in the tumour initiation and progression of NSCLC. To do this, I will develop a unique state-of-the-art conditional genetic mouse model of NSCLC in which HDAC6 is knocked out. I will do this work in the laboratory of Prof. Wong at New York University, an expert in conditional genetic mouse models. I will study the role of HDAC6 on the immune-microenvironment of the lung tumours using multi-parameter flow cytometry and single cell RNA-sequencing. Upon re-integration to the host laboratory I will establish the HDAC6 knockout NSCLC mouse model. Lastly, I will assess the efficacy of the novel HDAC6 inhibitor on tumour progression compared to the mouse model. This project has the potential to contribute greatly to our understanding of the role of HDAC6 in NSCLC and lead to the discovery of targeted therapeutic. Through this prestigious fellowship I will diversify my research skill-set, I will gain international experience in a world-leading laboratory of NSCLC and I will be excellently positioned to develop my independent research career on return