RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Supporting UPtake Integrated Pest Management and lOw-Risk pesTicide Use' (SUPPORT), addressing dissemination and exploitation.

assistant: **Impact**

Research has shown that well-designed integrated pest management programmes (IPM) are a viable solution to reduce the dependency on use of chemical pesticides. However, the uptake of IPM practices by farmers remains low, creating a challenge to support adoption of those techniques. This requires thorough understanding of the decision-making process of farmers and other involved stakeholders in order to improve strategies and policies that enables and stimulates the application of IPM. SUPPORT responds to this challenge by increasing the capacity to understand the environmental, social and economic impacts of existing and future crop protection systems in which IPM is applied, by creation of an inventory of IPM tools and techniques and the development an impact monitoring system. Farmers behave in an economic, social and institutional environment. SUPPORT will identify barriers and opportunities in the entire agrifood-chain for the adoption of IPM and analyse qualitatively and quantitatively their role in farmer decision-making. Data will be collected by interviews, surveys, choice experiments and derived from the FADN. The results of this analysis will be used as a basis for the development of strategies and policies enabling and supporting farmers and other stakeholders to apply IPM. The develop takes place in a co-creation process with stakeholders. Therefore, a multi-actor approach will be the backbone of the research process. 26 National Crop Clusters (NCCs) will be used for data collection. In 9 of those NCCs, Community of Practices (CoPs) will be developed with public and private stakeholders to co-create strategies and policies. The CoPs will be embedded in a Network of Practice (NoP), an overarching platform connecting all stakeholders. This NoP will be used to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MAGNETIC SYSTEMS AS CANDIDATES FOR QUANTUM COMPUTING HARDWARE.' in the context of a Fifth Framework call.

assistant: **Objectives**

Quantum storage and processing of information allow new computational tasks impossible with any conventional information technology. Such quantum computing (QC) requires a system of many quantum bits: qubits. This is an ASSESSMENT PROJECT to investigate a new QC candidate system, based on magnetic qubits. We propose to investigate both magnetic molecular clusters and dielectric nanometre-size single domain magnetic particles.The main objectives are:1) Understanding magnetic qubit decoherence, through comparison of resonance experiments with theory;2) Measurement of a single magnetic qubit, using a micro-SQUID. Expected project results are data on and understanding of qubit quality factors, data on single qubit detection and supporting theory/modelling. Quantum storage and processing of information allow new computational tasks impossible with any conventional information technology. Such quantum computing (QC) requires a system of many quantum bits: qubits. This is an ASSESSMENT PROJECT to investigate a new QC candidate system, based on magnetic qubits. We propose to investigate both magnetic molecular clusters and dielectric nanometre-size single domain magnetic particles.The main objectives are:1) Understanding magnetic qubit decoherence, through comparison of resonance experiments with theory;2) Measurement of a single magnetic qubit, using a micro-SQUID. Expected project results are data on and understanding of qubit quality factors, data on single qubit detection and supporting theory/modelling.OBJECTIVESWe aim to investigate a new QC candidate system, based on magnetic qubits. If successful, we expect this investigation to lead to a longer term research effort to explore fully the possibility of magnetic QC and to initiate the development of magnetic QC technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Co-targeting androgen receptor signalling and DNA damage repair for precision therapy in advanced prostate cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

Prostate cancer is the 2nd most common cancer in the western world. The advanced stage, metastatic castration-resistant prostate cancer (mCRPC), is a lethal disease. Understanding inter-patient genomic heterogeneity renders the opportunity to advance towards personalised patient care. Prostate cancer is a disease primarily driven by the androgen receptor (AR) pathway; however, the applicant prior work contributed to identifying 1) that up to 25% of mCRPC harbour defects in DNA damage repair (DDR) genes, and 2) that some of these mCPRC patients with DDR defects are sensitive to targeted treatment with PARP inhibitors.  In the proposed research plan, we aim to exploit the cross-regulation between AR and DDR pathways to optimize precise therapeutic options for mCRPC patients.   To achieve the objectives, the applicant will use models generated at the host through CRISRP/Cas9 to pursue functional studies and characterise how defects in ATM impact DDR function and sensitivity to inhibitors of PARP, ATR and DNA-PK. We hypothesize such sensitivity would be modulated by co-targeting of the AR pathway and by second events such as TP53 loss-of-function. ChIP-Seq assays will be pursued to identify genes co-regulated by the androgen receptor and PARP-1, to identify potential synthetic vulnerabilities. Then, mCRPC patient’s biopsies acquired in clinical practice from patients receiving AR-targeting therapies will be used to study how AR inhibition modulate transcriptional regulation of DDR pathways, to inform the optimal design of combination therapies. These data would be correlated with genomics and immunofluorescence tests of homologous recombination function, in order to refine patient stratification in the clinic.  The proposed research will be conducted in parallel to a person
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Theoretical Chemistry and Computational Modelling'.

assistant: **Concept**

Theoretical Chemistry and Computational Modelling (TCCM) is emerging as a powerful tool to help in the rational design of new products and materials for pharmaceutical, chemical, energy, computer, and new-materials industries. To achieve this goal, it is necessary to go beyond the traditional electronic structure studies, and merge complementary techniques that are normally not available at a single research group. The research programme of the TCCM-EJD aims at applying computational modelling to problems demanded by the industry and with high societal relevance, namely Materials with special properties, Biomolecules for new therapies and Energy storage. The objective of the Joint Doctorate is to prepare future research leaders, able to develop and use multidisciplinary computational techniques (methods and software), with solid communication skills, with many contacts established through the intensive relationship with worldwide leading researchers of 12 European universities and 14 additional partners, including 7 industrial and spin-off companies. A Joint Doctorate in TCCM is already operative since 2011, based on a fully participative scientific discussion and assessment of all research projects with a clear interdisciplinary character and the direct participation of the non-academic sector.  The training programme puts the emphasis in common training, including 3 annual International Workshops, 3 schools on High Performance Computing and 3 tutorials in new computer codes. Career development opportunities are enhanced with regular inter-sectoral activities, transferable skill education and career coaching.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Question Answering Learning technologies in a multilingual and multimodal Environment' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Nowadays, voice portals provide users with a broad variety of information (timetables, traffic circulation, weather forecast, cultural events, etc.), and are experiencing an exponential increment of popularity. Most of the times, the common factor of the sought after information is its dynamism: the world rapidly changes over the time, users ask (and pay) for completely fresh information. Gathering and maintaining all the relevant information, and providing users with complete and updated contents are undoubtedly a bottleneck and an expensive work for voice portals and web-based information services. Doing it better can mean the difference between their success and failure.Open Domain Question Answering (QA), the core technology behind the QALL-ME project, provides at the same time both a research and technological framework to address the above-mentioned issues and a challenging applicative perspective for real use scenarios. In contrast to the technologies behind today's web search engines, the goal of QA is not to return a list of documents, but the actual sequence of data (i.e. words) which constitutes the answer. The scientific and technological objectives of the project address three crucial directions: multilingual open domain QA, user-driven and context-aware QA, learning technologies for QA.The potential of open domain QA will be experimented and evaluated in the context of mobile applications for information seeking, a multimodal scenario which includes spontaneous speech as input and the integration of textual answers with maps as for output. The selected domain is represented by local events in a town, usually available either through specialized web sites or local newspapers and publications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Exascale Software Initiative - 2010/2011' (EESI).

assistant: **Innovation**

The European Exascale Software Initiative (EESI) goal is to build a European vision and roadmap to address the challenge of the new generation of massively parallel systems composed of millions of heterogeneous cores which will provide Petaflop performances in 2010 and Exaflop performances in 2020. These capabilities lead to outstanding technological breakthrough possibilities in computations and simulations which will be reached only if an international cooperation work program is set up.<br/>This will be done through a set of conferences and work groups involving a very large number of HPC European actors and users. They will investigate where Europe stands in the overall international HPC landscape and competition, what are its strengths and weaknesses, and whether such or such topics and challenges should be addressed inside or outside Europe. EESI will also identify the sources of competitiveness for Europe induced by the development of Peta/Exascale solutions and usages.<br/>The overall challenge must be faced at worldwide level to be attainable. A close collaboration with the EU PRACE project which is preparing the tier-0 level of the European HPC ecosystem, will be implemented. Coordination with the International Exascale Software Project (IESP) launched by The Department Of Energy (Office of Science), National Science Foundation and Department Of Defense is planned. The project leader of IESP, Jack Dongarra, and the Japanese executive member of IESP, Satoshi Matsuoka, are contributing participants of EESI.<br/>Expected outputs of the project are a roadmap and a set of recommendations shared by the European HPC community, on tools, methods and applications to be developed for this new generation of supercomputers. Coordination with international actors working o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innate intracellular blocks to HIV-1 in New World monkeys' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Currently there are approximately 33.4 million people living with HIV-1 worldwide and it is estimated that every year AIDS claims about 2-3 million deaths while HIV-1 is responsible for an equal number of new infections. In spite of the advances in the fight against HIV-1 since the isolation of the virus in 1983, there is still no vaccine available for the prevention of HIV-1 infection, and so far the available therapies have failed to eradicate the virus. The use of animal models for the development of vaccines, testing of new antiviral drugs, and studies of pathogenesis has been invaluable. The presence of several barriers to HIV-1 replication in cells of many species narrows the species tropism of HIV-1 to humans and chimpanzees. The most widely used animal model for AIDS is the infection of Asian macaques by simian immunodeficiency virus (SIV) or simian-human immunodeficiency virus (SHIV) chimerae. The development of models in which the host animal can be infected with more HIV-1-like viruses is a worthy goal. Such a new animal model would be useful for studying viral pathogenesis and for testing antiviral therapies and vaccines. Here, we propose to study the host cell restriction factors that block the replication of HIV-1 in common marmoset cells, with the long term goal of developing a new animal model for HIV-1 infection using the common marmoset, a New World monkey, as a host animal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transformation of healthcare for excellence in strategy information and service' (THESIS).

assistant: **Innovation**

The mission of the THESIS project is to gain competitive advantage, by the transformation of management processes, organisational capability and information services within the healthcare sector. The key themes being the elimination of wasteful bureaucracy, and maximising responsiveness to changing markets. THESIS is driven by the needs of two European Healthcare providers , Teddington Memorial Hospital and Athens Medical Centre, who require transformation of business processes from traditional, profession-led activities to efficient market-led services.THESIS is built on the results of European and national projects on Business Process re-engineering and adopts the SHINE business process re-engineering methodology as developed and validated under AIM. THESIS compliments other information support projects such as CISP and ESPRIT TBP projects HOCAPRIT and COBRA, which focus only on the clinical business process. In contrast, THESIS focuses on management rather than clinical best practice and as such presents a transferable model for other small-to-medium scale enterprises beyond healthcare.It is clear that across Europe the rapid political and social changes are resulting in a clear need for the healthcare delivery business to transform into leaner, more responsive small enterprises. What THESIS will provide for the sector are clear examples of best practice in the use of technologies for business process transformation, demonstration of its benefits and a business justification and payback time for the return on capital invested.Both users have clearly defined their existing business situation and have established strategic goals and objectives, aimed at positioning their organisations to be more efficient, competitive and deliver higher standards of quality. This clear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'UltraCLEAN thermoforming equipment for food PACKaging, a cost-effective alternative to clean rooms'.

assistant: **Objectives**

Nowadays only big food processors can count with aseptic packaging conditions. CleanPack the packaging machine provides the food safety standards of a clean room at a small scale. In response to our customers needs, TECSELOR has developed the CleanPack prototype that allows the ultraclean/aseptic packaging of food products which will represent a cost-effective alternative for a clean room providing the same level of food safety.CleanPack goes beyond clean rooms in terms of shelf-life extension of foods. This goal could be achieved, as the encouraging results of the CleanPack new packaging technique, which combines 3 patented technologies: sterile thermoforming and packaging, filling with surface decontamination of perishable fresh foods, and ultraclean laser cutting of trays. The integration of these techniques in a whole CleanPack machine will allow SME packaging to maintain the same level of food safety than clean rooms and extend shelf-life and freshness of their packed foods even more than big producers.The food industry sector of preparation and packaging of solid refrigerated foods such as dairy products, meat, fish, ready meals and salads or cut fruits and vegetables is demanding increasing levels of hygiene, which enable the product to be packaged with minimal microbial contamination or commercial sterility conditions (aseptically). CleanPack retains the fresh-like characteristics of foods as clean label, since no need for addition of further chemical preservatives, being able to extend the products shelf-live a minimum of 150%. The implementation of this milder technology also has the potential to reduce energy consumption, besides reducing the dependence from cold-chain logistics which enables decentralized production, adding sustainability and reducing costs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Wiring up the SomatoSensory Cortex' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding how the mammalian brain network acquires its ability during development to process information and interact with the environment is one of the fundamental challenges in modern biology.The brain originates from a sheet of neural progenitors during embryogenesis but rapidly develops into distinct functional areas such as primary sensory and the highly associative cortices. Although all cortical areas consist of the same main neuronal elements, excitatory and inhibitory cells, their functions are markedly distinct. Unlike others, primary sensory cortical regions receive direct inputs from the environment through the respective thalamic nuclei starting at an early stage in development and are therefore likely to be shaped by incoming activity from sensory modalities. Despite the plethora of data on the arealization of the cortex by early signaling centers and the critical period plasticity mechanisms which take place after the basic elements of the circuit have been laid out, very little is known about the important period in between and how individual elements bind together to construct a functional circuit.  This proposal is aimed at bridging this gap in knowledge, by addressing the long-standing question of how genes and activity interact during development to establish the correct wiring of excitatory and inhibitory cells in cortical sensory areas.As the primary role of inhibitory cells is to shape the flow of information transfer in the brain, they are well positioned to contribute significantly to the distinct modes of information processing performed in different cortical areas. Considering that dysfunction of cortical inhibitory circuits has been proposed as a major contributor to the etiology of neuropsychiatric-neurodevelopmental disorders, it is my