RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Meiotic recombination : the role of the mouse spo11 protein'.

assistant: **Innovation**

The project aims to analyse the molecular mechanism of the meiotic recombination in mice.Deregulations of meiotic events, which are still not well understood, lead to gamete alterations. either to a decrease of fertility, or to chromosomal anomalies which both are a major human health issues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'European network staff eXchange for integrAting precision health in the health Care sysTems'.

assistant: **Innovation**

The aim of the “European network staff eXchange for integrAting precision health in the health Care sysTems (ExACT)” is to train a new generation of professionals that can contribute to the future of health and healthcare (HC), by providing high-quality, multidisciplinary knowledge in precision health. The greater personalisation of HC is a driver of innovation for research, and for the healthcare system and industry. Still policy makers, HC professionals, citizens, and private companies need to take some steps to realize its potential. In order to harness this challenging landscape, the ExACT consortium provides a cohesive framework for training staff across 7 EU Countries, 1 AC and 2 TCs. During 4 years, the staff involved will be trained on research topics not available at the home institutions thanks to 74 secondments. They will attend courses, workshops, seminars, conferences, and will participate in organizing outreach activities, thus acquiring new skills. Research topics include: Integration of Big Data and digital solutions into the HC systems; Designing and promoting innovative citizen engagement models; Education of healthcare professionals and leadership; Health Technology Assessment in precision health; Ethical-legal, social, organisational and policy issues surrounding precision health. ExACT is embedded in existing cooperation structures, such as the RISE-PRECeDI project, IC PerMed, and CSA TO-REACH. The consortium consists of 14 beneficiaries and 2 partners, of which 10 are academic institutions including Stanford University where a precision health program has been launched, and 7 non academics including 2 SMEs. The participants will produce key reports, policy recommendations, scientific publications, and information materials for citizens, thus foster
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Repurposing and enriching images for immersive storytelling through smart digital tools' (FotoInMotion) under Horizon 2020.

assistant: **Objectives**

The amount of digital content available to creative industries is growing exponentially, driven by the ubiquitous use of smartphones and the proliferation of social media: (1) there is a tremendous increase in the amount of photographic content (more than 1.8 billion photos are uploaded to social media platforms each day); (2) the ongoing transformation of factual, entertainment and social media publishers and platforms from textual and photo-centric format to video-driven format (more than 400 hours of video are being uploaded to YouTube each minute); (3) the increasing impact of 3D and virtual reality for providing immersive storytelling experiences, offering new ways of audience engagement and monetization for content creators in the upcoming years. Acknowledging the above, the following critical questions become imminent in both content production and dissemination contexts: how to repurpose this massive amount of content; what kind of innovative tools are most suitable for this process; and finally how these tools can offer new forms of monetization possibilities for creative industries' professionals.FotoInMotion, sets to solve these critical questions and provide an innovative solution to the repurposing of content by offering automated tools for innovative contextual data extraction, object recognition, creative transformation, editing and text animation as well as state of the art 3D conversion options that allow content creators to transform their photos into highly engaging spatial and three dimensional video experiences.  FotoInMotion will focus on three major creative industries sectors: photojournalism to develop interactive photo driven stories; fashion, by opening up new forms of marketing, product placement and event coverage; and festivals, by enabling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Working group on evaluation and synthesis of information on tree cover to balance productivity and biodiversity in agricultural landscapes along the Mesoamerican biological corridor' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This support action seeks to co-ordinate activity and build capacity amongst Central American countries to develop a research strategy for defining thresholds for tree cover that balance biodiversity conservation and productivity in agricultural landscape s along the Mesoamerican Biological Corridor (MBC). It builds upon and combines data collected and methods developed in Central America in two complementary EU INCO projects, FRAGMENT (ICA4-CT-2001-10099; 2001-2004), concerned with landscape level tree c over and biodiversity on pastures and CASCA (ICA4-CT-2001-10071; 2001-2005), exploring impacts of tree ver on coffee productivity. Implications of the findings from three Central American countries (Costa Rica, Guatemala and Nicaragua) will be explored i n the context of the whole Mesoamerican region stretching from Mexico to Colombia. This is to be achieved by establishing working groups comprising delegates from key research institutes from countries within the Mesoamerican region co-ordinated by CATIE and two European research centres with expertise in systems analysis and ecology and tree and crop physiology. The groups will collate information on tree cover, biodiversity and productivity in coffee plantations snd pastures respectively along the MBC, and in workshops for each land cover type develop protocols for data collection and interpretation that facilitate their inclusion in comparative analysis across the region. These findings will be combined and discussed at a synthesis workshop that will draw conclusions from the existing data, identify knowledge gaps and develop an integrated research strategy to define threshold levels of tree cover in agricultural landscapes along the MBC, with a view to future participation in EU programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reduction of adverse environmental impact of demersal trawls' (REDUCE).

assistant: **Concept**

The main objective is to asses methods to reduce the adverse impact of demersal trawls on benthic marine organisms through changes in net design and alternative methods of stimulation.EU funded research has shown that commercial beam trawling has detrimental affects on the structure and composition of benthic communities in the North Sea, as does otter trawling for Nephrops in the Irish Sea. It appears that short-lived species are favoured while longer-lived species are more adversely affected, with the result that the disturbed communities may favour scavengers, and predators other than fishery target species. Reducing potential damage to longevous benthic invertebrates could result in more viable standing crops of prey for target species. This project seeks to find technical solutions whereby the adverse effects of demersal trawls on benthic organisms can be significantly lessened.The work programme will therefore:review alternative techniques that could reduce the adverse effects of demersal trawls on marine benthic organisms, and to identify, in co-operation with the fishing industry, those with most promise for further investigation.investigate the practical feasibility of the identified alternative techniques with respect to the following criteria: reduction of fish/benthos by-catch, effectiveness, economy, and acceptability to the fishing /scientific community, and to refine selected alternatives, driven by the requirement that catch levels can be maintained with emergent new gear designs.evaluate the impact of the modified gear by taking representative benthos samples prior to and after its passage along accurately demarcated transects. Results will be disseminated to the fishing industry and the scientific community, using appropriate paper documentation and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a novel human derived probiotic species platform - Phase 1' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The global probiotics market is flourishing and anticipated to grow substantially in the coming years due the highly promising application of next-generation probiotics (NGPs) as live biotherapeutic products (LBPs). Whereas traditional probiotics are mainly derived from non-human origins with limited positive effects, NGPs are human-derived and play a key role in a healthy microbiota. All major probiotic companies are now moving into this field, however they are struggling with product development due to the intrinsic properties of NGPs. As a result, no NGP products have successfully reached the market yet. NGP product development requires radically new techniques for cultivation and production. This untapped market segment is highly attractive for Winclove. To tackle this problem, Winclove is developing the NOVOBIOME platform – covering the full cycle of NGP product development. Winclove’s approach leverages its already functional in-house facilities and infrastructure and combines it with innovative models and technological methods that can fast-track the timeline of NGP product to market for our clients. Winclove, an innovative Dutch SME, is a leader in microbiota-management, which hasbeen offering services in research, development and manufacturing of probiotic formulations for over 25 years. Winclove has been very successful in growing the company into a sustainable business with 73 FTE, growing 14% per annum on average. It provides its services to over 80 customers in 35 countries worldwide. As such, it has sold via its clients over 130 million daily dosages in 2018. Winclove aims to provide the NOVOBIOME platform as a B2B fee for service to dedicated innovative companies that are working on NGP-based LBPs. Winclove anticipates to generate €8M in turnover within t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Tumor acidosis targeted delivery of immunotherapy by Marker-Agnostic TumoR-Anchoring Chimeras'.

assistant: **Innovation**

Cancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity compared to traditional therapies. However, despite significant progress, current immunotherapies face limitations, particularly in targCancer immunotherapy represents a groundbreaking advancement in oncology, leveraging the immune system to combat malignancies with enhanced specificity and reduced systemic toxicity compared to traditional therapies. However, despite significant progress, current immunotherapies face limitations, particularly in targeting tumors without identifiable antigenic signatures and avoiding immune-related adverse events. In my ERC project I will explore an innovative approach utilizing Marker-Agnostic TumoR-Anchoring Chimera (MATRAC) technology, designed to harness the universal acidic microenvironment of solid tumors for targeted delivery of immune-modulating therapies. MATRACs are engineered recombinant fusion proteins that combine a therapeutic payload with a pH-responsive anchoring mechanism, ensuring selective activation in acidic tumor sites while minimizing off-target effects. Preliminary studies demonstrate MATRACs' enhanced tumor localization, pH-selective membrane binding, and potent immune-stimulating effects, laying the groundwork for their development as a versatile platform for innate immune-mediated cytotoxicity, cytokine therapy, and T-cell engagement in various cancer models. This research aims to optimize MATRACs' therapeutic efficacy and safety, with comprehensive preclinical evaluations including pharmacokinetics, immunogenicity, and toxicity assessments. By addressing critical gaps in current cancer immunotherapy, MATRAC technology holds the pot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Continuous reactor/extractor for processing of solid materials with supercritical fluids' to be submitted under Fifth Framework.

assistant: **Abstract**

Consumer products (extracts, advanced polymers) are often processed with organic solvents, leaving unhealthy residues in the product. Clean solid processing can be achieved with supercritical techniques, at present batch wise processes e.g extractions. The main objective of the project is generation of knowledge needed to develop a continuous supercritical reactor-extruder. The innovative aspects of the system are usage of a twin screw extruder under high pressure, realisation of restrictions in the solid flow and integration of a continuous charging/discharging system. Extension from batch to continuous operation means high savings on processing and cleaning. Furthermore, profitability of existing processes will be increased and new applications created for industry, e.g. chemical reactions, impregnation and particle technology in the medium- long term.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'POINT OF CARE DEVICE FOR VITAMIN D DEFICIENCY MONITORING' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

OSASEN is a young technological SME focused on the development of novel biosensors for healthcare (Point of Care-PoC devices), addressing priority needs in healthcare diagnostics and/or therapies monitoring for the benefit of patients, providing affordable systems with unique features that meet specific well identified requirements in healthcare. OSASEN has recently identified a healthcare need in relation with prevention, treatment and monitoring of Vitamin D (VitD) deficiency. VitD (1,25-DihydroxyvitaminD) is considered a multipurpose steroid hormone that in human plays an essential role in multiple aspects, being its primary role to participate in the regulation of metabolism of calcium and phosphorous. VitD deficiency is evident throughout the European population at a prevalence of 13% (FP7-613977-ODIN project), a rate that is a matter of concern. People over 50 have an increased risk of vitamin D deficiency with consequent bone loss risk leading to osteoporosis and fractures. Emerging evidence has shown that VitD administration improves muscle performance and reduces falls in VitD deficient older adults. Other populations of higher risk for VitD deficiency are children, pregnant and lactating women and patients with digestive disorders, among others. VitD deficiency is also associated with increased risk of cancer, cardiovascular disease, infections, and autoimmune diseases. For example, several studies have shown that VitD levels are lower in Multiple Sclerosis patients, and monitoring and VitD supplementation to them is highly recommended. In this context, OSASEN has identified the opportunity to develop a novel PoC device for the quantification of VitD in blood or urine based on lateral flow (LF) immunoassay, combined with electrochemical detection on screen pri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular chirality tools for the study of Gluten Immunogenic Peptides and Celiac Disease: Novel therapeutic and diagnostic approaches.' to be submitted under Horizon Europe.

assistant: **Abstract**

Celiac disease (CD) is a systemic autoimmune disorder triggered by gluten consumption in genetically predisposed individuals, affecting a substantial portion of the European population (1.4%). A significant number of CD cases remain undiagnosed (75%), leading to untreated disease and its associated symptoms. These range from immediate gastrointestinal and extra-intestinal distress to long-term complications such as osteoporosis, infertility, and cancer, among others, placing substantial strain on society and healthcare systems. As the primary treatment for CD remains a strict gluten-free diet, there is a pressing need for innovative approaches to alleviate the burden of inadvertent gluten exposure. This proposal aims to investigate the molecular mechanisms governing the transport of gluten immunogenic peptides (GIP) across the small intestine and to develop a chiral-based strategy for the design of enantiomeric peptides that can inhibit GIP toxicity and immunogenicity. Our objectives are: 1) To develop a focused library of enantiomeric peptide inhibitors of GIP that could be used as novel therapeutic agents for CD. 2) To elucidate the molecular mechanisms of GIP transport and immunogenicity across the small intestine using GIP enantiomers as probes. 3) To establish a liquid chromatography–mass spectrometry (LC-MS) assay for GIP quantitation in biological samples as a novel diagnostic tool for assessing gut permeability in CD patients. The successful accomplishment of these objectives will provide valuable insights into GIP activity and transport within intestinal epithelium and immune cells. Moreover, it offers the potential to identify novel peptide-based therapeutics against GIP, with the possibility of further commercialization. Lastly, the success of this proposal c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Sequencing and Genotyping Infrastructure' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The objective of this project is the integration of world class high-throughput sequencing and genotyping facilities that will provide sequencing and genotyping technologies and data analysis methodologies to the scientific community.The European Sequencing and Genotyping Infrastructure (ESGI) will enable external users to generate data rapidly and to acquire knowledge efficiently. By providing access to the ESGI facilities in order to benefit from the sequencing and genotyping technologies, there will be an outreach and sustainable impact for the scientific community in the area of biological and medical research to generate new knowledge.The ESGI will optimise European research programs and foster transnational collaborations. In general, the ESGI will defragment and thereby strengthen the European research capacities in genetics and genomics and improve the knowledge transfer from large genomics centers among themselves and to external expert groups or scientists who are focusing on specific research questions.Our aim is to apply and improve new high-throughput nucleic acids analysis technologies for a broad range of genetic and systems biology studies using well-phenotyped samples, for example those derived from standardised European biobanks and animal facilities. In particular, massively-parallel sequencing technologies are essential components of modern biomedical research and are ready to reveal molecular and cellular pathways underlying complex traits and common diseases.As the European Strategy Forum for Research Infrastructures (ESFRI) pointed out in the past, the development of an efficient infrastructure for sequencing and genotyping is of crucial importance to position Europe as one of the world-leading regions for genetics, genomics and systems biology re