RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Neural bases of action chunking in basal ganglia subcircuits' in the context of a Seventh Framework call.

assistant: **Objectives**

Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral unit at the neuronal level. Using a differential reinforcement procedure where mice learn to chunk rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. Besides activity signaling sequence initiation (start), we found neurons with sustained or inhibited activity throughout the execution of an entire sequence. These findings clearly show that basal ganglia circuits display neural activity related to the execution of whole action sequences, rather than unitary elements. Neurons with start, sustained and inhibited sequence-related activity were observed throughout the basal ganglia, namely in the main input (striatum), and output (substantia nigra reticulata) nuclei of the basal ganglia. However, the basal ganglia have different cell types/subcircuits linking input to output, the so called direct ves. indirect  pathways. Furthermore, basal ganglia output projects to different target areas. Here we will 1) determine if these correlates of motor concatenation are differentially expressed in direct versus indirect basal ganglia pathways by optogenetic identification of cell types in the striatum and in vivo imaging, 2) test the necessity and sufficiency of these two pathways in action sequence initiation and performance, and 3) test if different basal ganglia output circuits express and mediate different aspects of action chunking. These experiments will dissect with unprecedented spatial and temporal precision the role of basal ganglia subcircuits in the initiation and performance o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Green & Innovative Lubrication Devices' (GILD).

assistant: **Concept**

This proposal answers to the Clean Sky JTI call ""JTI-CS-2009-2-SAGE-02-003 - Design, computation and drawing of lubrication system equipment"".The goal of the proposal is to propose to the industrial partner mechanical skills regarding design and computation of lubrication system according to SAGE-2 counter rotating open rotor demonstrator.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bacterial Formation of Glycerol (di)Ether Lipids: Biogeochemical, (paleo)environmental and evolutionary implications' under Seventh Framework.

assistant: **Concept**

The three domains of life on Earth comprise the two groups of prokaryotes Archaea and Bacteria whom distinction notably relies on the chemical composition of cellular membranes. Bacteria generally synthesize phospholipids constituted of non-isoprenoid alkyl chains esterified to glycerol, whereas Archaea synthesize isoprenoid ethers of glycerol. These differences have potential implications in term of ecology and evolution of Bacteria and Archaea and are frequently used as distinguishing marks. Non-isoprenoid diethers of glycerol (non-isoprenoid DGD) constitute an exception to these chemical distinctions as they exhibit an intriguing combination of structural features of Bacteria and Archaea. The physiological role and the mode of formation of these lipids are poorly understood. Remarkably, these compounds have never been observed in mesophilic marine bacteria although they are omnipresent in non-extreme interfaces between the Biosphere and the Geosphere where their origin remains speculative.This multidisciplinary project aims at investigating in detail the first isolate of marine mesophilic sulphate-reducing bacterium able to produce non-isoprenoid DGD, and at comparing it with other (un)related strains. It relies on the combination of lipidomics (analysis of lipid biomarkers) with microbial ecology and microscopy coupled with spectroscopy (bacterial ecophysiology based on ultrastructure). Results will allow specifying the use of DGD as biogeochemical proxy and clarifying the link between living bacterial structures and the observation of microbial signatures within the sedimentary record. It should also shed light on crucial aspects of microbial ecology and on the evolution of lipid biosynthesis in prokaryotes.The project is based on preliminary results obtained by th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'New methodologies for automated modeling of the dynamic behavior of large biological networks'.

assistant: **Concept**

In silico models aim to capture and elucidate the complex and emergent interactions of biological systems, with the goal of expediting research and potential clinical translation. For example, ordinary differential equation (ODE) models of toxin and drug transport are being developed to bring safer therapies to chronic kidney disease patients. Despite recent progress, these cutting-edge ODEs only model transport in steady state and remain limited regarding the amount and complexity of dynamic transport mechanisms as it is often not clear which kinetic relation is most suitable. This limitation is due to the manual and labor-intensive approaches to construct the ODEs, which critically hinder their application in quantitative toxicity assessment in key industrial settings like drug development. In AUTOMATHIC, I will leverage and combine my expertise in mathematical modeling and machine learning to develop an integrated framework for automated ODE structure identification, parameter estimation and model evaluation, focusing on cell transport and signaling, which is the timely leap forward needed to create large dynamic models and transform the field. I will test and illustrate the capabilities of the developed framework by exploring the dynamics and regulation of proximal tubule (PT) toxin and drug transport. I will use the dynamic PT model to define novel therapeutic regimens that minimize toxin accumulation in combination with a state-of-the-art in vitro set-up to measure the essential time series data required for model calibration and validation. The anticipated outcomes of AUTOMATHIC are: 1) a next-generation, integrated framework for automated model structure identification and parameter estimation that will become the new standard for the creation and interrogation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Virtual Privte Home - Privacy-by-design Home Energy Efficiency Platform'.

assistant: **Concept**

Project objective “Virtual Private Home – Privace-Aware Home Energy Efficiency Platform” project aims to deploy on the EU market a new, gaming changing energy efficiency tool for residential customers, that will be characterized by its superior energy saving performance, open architecture and above all by its “Privacy-by-design” data protection concept. Product conceptThe Virtual Home product will be released in a form of an online service, accessible via internet, mobile and smart objects. The service will be associated with third party smart meters and smart home devices. It will use behavioral efficiency (green nudge) tool to engage consumer in energy saving, and its modular structure will enable connecting an infinite range of additional applications. It can enable to up 30% of energy savings. Each end-user will dispose of complete control of its private content, with a possibility to grant or revoke access, change hosting platform, destroy all data. The encrypted object storage approach will ensure access on ‘need-to-know’ bases.Feasibility assessment The feasibility phase will validate initial market insights: demand for privacy solution, size o home energy efficiency markets, and test concepts with initial test users.European and global dimensionResidential energy consumption represents 27% of overall EU energy usage, and energy expenses start to exceed 10% of household budgets in some EU countries. EU directives recommends deployment of smart metering and smart grid solution, while the new EU General Data Protection Regulation imposes very strict privacy by design rules. Privacy is a major barrier for deployment of home energy efficiency solutions.The project will be coordinated by GridPocket, successful start-up of 15 engineers and researchers based in France a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Tools and techniques for a Changing ATmosphere (TOTECAT): innovative approach on studying environmentally important questions'.

assistant: **Objectives**

TOTECAT aims at being a sound springboard for future world-class researchers and experts in the field of atmospheric chemistry/physics. The earth atmosphere including the impact of human activities on its chemical composition has long been recognized as a so-called complex" system.The atmosphere is also clearly a multi-disciplinary field of investigation ranging from chemical reactivity over combustion processes to transport of matter and radiative transfer. TOTECAT will offer to future scientists and engineers the basic knowledge of concepts and offers practical training of various techniques appropriate to tackle scientific or technical problems connected to the chemistry / physics of our changing atmosphere.The training includes- background courses in fundamental spectroscopy, chemical reactivity (heterogeneous and gas, combustion), radiative transfer etc.- practice of a broad range of mainly laser based techniques applied to scientific issues relevant to the atmosphere: laboratory kinetic experiments, in situ monitoring or remote sensing of trace species- practice of modeling techniques at various scales (from the molecular to the global atmosphere range) of both chemistry (pollution, combustion) and physics (radiation and climate).The core of the training consortium consists of 17 researchers / teachers from four laboratories located at the host institution USTL (University of Sciences and Technologies, Lille), all labelled by CNRS: PC2A (Physico-Chemistry in Combustion and Atmospheric Processes), PhLAM (Physics of Lasers, Atoms and Molecules), LASIR (Laboratory of Infrared and Raman Spectroscopy) and LOA (Laboratory of Optics of the Atmosphere).Included in our consortium are two regional inter-related groups: ULCO (University of Littoral, Dunkerque) and EMD (Minin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NGS diagnostics in 21st century oncology: the best, for all, at all times' to be submitted under Horizon 2020.

assistant: **Abstract**

oncNGS consortium challenges the market to research and develop novel affordable solutions to provide the best NGS tests, for all solid tumours / lymphomas patients. The challenge will consist in providing: (1) efficient molecular DNA/RNA profiling of tumour-derived material in liquid biopsies by means of (2) pan-cancer tumour marker analysis kit including NGS analysis integrated with (3) an ICT decision support system including analytical test interpretation and reporting. Thanks to the provided solutions, oncNGS consortium will be able to address their common identified unmet medical needs: (1) Establishment of valuable common tumour profiling strategy allowing to provide equal access to innovative medicines to all; (2) Outcome research analysis after treatments with targeted therapies as diverse testing leads to lowering the pooling capacity of obtained results, needed to obtain large enough sample numbers to perform statistics analyses; (3) Application of such essential testing to all patients, breaking down current unacceptable inequities due to the high costs of current diagnostics tests.oncNGS is a strong consortium composed by eight buyers from five member states (SC and IJB from Belgium, IC and HCL from France, HC and LMU from Germany, ACC from Italy and ICO from Spain) supported by six entities with wide experience in their fields (AQuAS from Spain is expert in precommercial procurement, BCR from Belgium and INCa from France are experts in cancer control, IBSAL and VHIO are experienced in biomedical research in the field of haematologic malignancies and DCP is experts in intellectual property rights and freedom to operate analysis) oncNGS consortium will challenge the market launching a pre-commercial procurement procedure, a competitive process enabling the b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EXpAnding LTE for Devices' (EXALTED).

assistant: **Innovation**

The number of networked humans will reach saturation by the middle of the next decade, while the number of networked devices will continue to increase dramatically for some time to come. The Wireless World Research Forum (WWRF) has set out a vision of the future where 7 trillion wireless devices will be serving 7 billion people by 2017. The vast majority of wireless traffic will be between machines in remote locations. However, wireless communication networks have been designed mainly with human users in mind. And while scale and type of M2M applications are growing rapidly over today's cellular networks, they are still defined following mainly human's communication requirements. To meet the requirements of M2M applications, a new kind of network is needed to serve efficiently a huge number of devices which may have rather modest communications needs.The project will work towards meeting following main aims: To develop and provide a new architecture to support efficient and cost-effective wireless M2M communications. To provide energy efficient wide area coverage for M2M applications such as wireless sensor networks. To extend the scalability of the LTE infrastructure with the aim to extend the range of applications to very cost sensitive mobile narrowband" applications. To develop a cost, spectrum and energy efficient radio access technology for M2M applications, adapted to coexist within a high capacity LTE network. To increase energy efficiency of devices, as they may need to be autonomous for months or years. New sleep mode optimization and wake-up mechanisms will be developed within the LTE extensions.Achieving these aims, EXALTED will impact both the network and service infrastructure, and also the use and exploitation of LTE networks, thus boosting the Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spin-Phonon interaction for Energy Conversion' (SPEC), addressing dissemination and exploitation.

assistant: **Impact**

Heat dissipation is one of the great challenges for microelectronic and information technologies, which is aggravated by the reduction of the transistor dimensions and the increases in packing density and amount of data. Therefore, beyond CMOS technologies and heat management strategies are important challenges that need to be faced for the sustainable development of a knowledge-based society.  The exploration of spin-based devices exploiting novel mechanisms is one of the possible routes to explore. In particular, insulator spintronics has great potential. Since magnetic insulating materials (mostly transition metal oxides, TMO) can offer lower heat dissipation due to the absence of charge carriers and no Joule heating losses. Moreover,  TMO can offer new functionalities due to the mutual interaction between several degrees of  freedom: electronic, magnetic, lattice. One example; is the spin-lattice interaction which has recently gained increased attention.In this present proposal, I will explore magnon-phonon interaction effects in suitable magnetic insulating materials to investigate their potential for magnetic-field-controlled heat-rectification effects, as well as their contribution to spin-based thermoelectric conversion phenomena (spin Seebeck effect).I will carry out the proposed research under the supervision of Prof. F. Rivadulla at CIQUS-USC and secondments in the group of Prof. M. Klaui at JGU-Mainz, thereby making use of the complementary expertise and stablishing a collaborative work environment between both institutions. Moreover, the experience I acquired during the last 5 years in Prof. Saitoh laboratory at Tohoku University will be critical for the success of this project, placing me in an unbeatable moment to tackle this ambitious research.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Action selection under threat: the complex control of human defense' (ActionContraThreat) under Horizon 2020.

assistant: **Objectives**

Run away, sidestep, duck-and-cover, watch: when under threat, humans immediately choreograph a large repertoire of defensive actions. Understanding action-selection under threat is important for anybody wanting to explain why anxiety disorders imply some of these behaviours in harmless situations. Current concepts of human defensive behaviour are largely derived from rodent research and focus on a small number of broad, cross-species, action tendencies. This is likely to underestimate the complexity of the underlying action-selection mechanisms. This research programme will take decisive steps to understand these psychological mechanisms and elucidate their neural implementation. To elicit threat-related action in the laboratory, I will use virtual reality computer games with full body motion, and track actions with motion-capture technology. Based on a cognitive-computational framework, I will systematically characterise the space of actions under threat, investigate the psychological mechanisms by which actions are selected in different scenarios, and describe them with computational algorithms that allow quantitative predictions. To independently verify their neural implementation, I will use wearable magnetoencephalography (MEG) in freely moving subjects. This proposal fills a lacuna between defence system concepts based on rodent research, emotion psychology, and clinical accounts of anxiety disorders. By combining a stringent experimental approach with the formalism of cognitive-computational psychology, it furnishes a unique opportunity to understand the mechanisms of action-selection under threat, and how these are distinct from more general-purpose action-selection systems. Beyond its immediate scope, the proposal has a potential to lead to a better understandi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pyruvate dehydrogenase and the control of respiration in plants' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Pyruvate dehydrogenase (PDH) is a key control point in eukaryotic carbo metabolism and thus highly regulated. Plant cells have two forms of PDH one in the mitochondrion and one in the the chloroplast. The object of my proposed study is to determine the regulation of mitochondrial PDH in vivo. This will be performed using antisense technology in transgenic potato plants transformed with the E1a subunit, pyruvate decarboxylase. Transgenic plants with altered amount of E1a protein will be studied. Transgenic mitochondria will then be compared to wildtype mitochondria in respect of oxygen uptake, citric acid flux and the PDH activation state of the enzyme in vivo. I will use the transgenic plants to determine the flux-control coefficient of this step on the respiratory flux and thus determine the importance of PDH in regulating respiration in vivo Such studies are of fundamental importance towards an understanding of how crop yield can be improved by biotechnology.