RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Further improvement of radiotherapy of cancer through side effect reduction by application of adult stem cell therapy' (FIRST).

assistant: **Concept**

Radiotherapy is the second most important treatment modality after surgery in the treatment of cancer. At the present over 50 % of all cancer patients receive radiotherapy at one stage in their course. Inevitably normal tissues are exposed to ionising radiation during radiotherapy of tumours. This can result in organ failure and hence seriously can limit the treatment dose. Reduction of the side effects of radiotherapy will not only increase the quality of life after the treatment but may also result in increased survival of cancer patients as it will allow dose-escalation to the tumour. This is true even if the most optimal physical dose-delivery (conformal therapy, protons) of radiation is applied. Radiation-induced organ failure is mainly caused by stem cell sterilisation, leading to a reduced reconstitution of functional cells. Replenishment of the depleted stem cell compartment should allow regeneration of irradiated tissues. Multipotent stem cells have now been shown to reside in multiple adult tissues. The innovative vision of this project is to reduce radiation-induced complications through stem cell therapy. Hereto, bone marrow derived stem cells will be isolated, mobilised and characterised. Thus obtained stem cells will be tested for their capability to ameliorate radiation-induced complications in organs affected by radiotherapy. After completion of the project (at 24months) the obtained scientific and (bio) technological knowledge and expertise on stem cells and radiation must have established the potential of stem cell therapy to restore normal tissue functioning after irradiation. This should set the stage for the second phase of the project (25-60 months) in which methods are further improved and, importantly, late responding tissues are included. A succ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CD-MB: Development of an electrochemical Molecular Beacon based DNA Chip for Coeliac disease predisposition diagnosis' (CD-MB) targeting Seventh Framework.

assistant: **Abstract**

Coeliac disease, a lifelong disorder, has become one of the most common food intolerances. This is due to an autoimmune reaction trigged by the ingestion of gluten a protein present in wheat, rye, secalins and barley; resulting in chronic inflammation of the mucosa of the small intestine. This inflammation results, in the affected person, in several symptoms as: impaired growth, anemia, weight loss, unhappy behavior and malabsorption. Due to the wide clinical spectrum of Coeliac disease its asymptomatic diagnosis is extremely difficult; currently a biopsy of the small intestine and the evaluation of its conformational changes or lesions is the most reliable and commonly used diagnostic approach. Recently susceptibility to Coeliac disease has been shown to be strongly associated with the region of chromosome 6 that codes for the HLA (Human leukocyte antigen) antigens; DQ2 and DQ8 genotypes have been shown to be associated, in almost 100% of the cases, to this disease. Nano-particles have found large interest in electroanalysis due to their enhancement of mass transport, their catalytic properties and their high effective surface area. Recognition and signal generation are key elements in the performance of genosensors. Their integration in a single element is a very important area of research in genosensor technology. Molecular Beacon, short oligonucleotides chains engineered to perform as recognition element and signal generator, is an extremely attractive tool with respect to this need. The most common format of molecular beacon is the fluorescent but more recently electrochemical molecular beacon are gaining ground in the In this work an electrochemical DNA-chip, based on the combination of nano-particles and electrochemical molecular beacon will be developed and char
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mutagenesis and functional analysis of the dnhlh genes id2 and id4 in vivo', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The research proposal is designed to elucidate the molecular mechanisms regulating developmental programs. A particular type of transcriptional regulators, the basic helix-loop-helix (bHLH) proteins, have been implicated in cell proliferation and differentiation in several systems. The dominant negative (dn) HLH proteins (ld1, ld2, ld3, ld4 and emc) appear to act as general antagonists of differentiation by inhibiting bHLH proteins. The dnHLH protein ld2 is also involved in cell cycle regulation since interaction of ld2 with the retinoblastoma Earotein (pRb) resulls in cell cycle progression. Targeted disruption of the dnHLH genes ld4 and ld2 will be performed to analyse the in vivo function of the gene products. Expression of dnHLH genes in neural precursors strongly suggests, that gene disruption of ld2 and ld4 effects the neural embryogenic development. Detailed analysis of the null mutants will reveal new molecular aspects of differentiation and proliferalioll processes dul ing neurogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanobiologically mimetic model systems for study of Bone disease (MEMETic)'.

assistant: **Innovation**

Despite immense efforts to develop therapies for osteoporosis, conventional drugs that target bone loss only prevent osteoporotic fractures in 50% of sufferers, and the worldwide economic burden of treatment is projected to reach $132 billion by 2050. Recently our research has (1) identified important tissue-level changes in osteoporotic bone and (2) provided evidence that the biological mechanisms by which the cells normally respond to their mechanical environment are altered. However, no existing therapeutic approach has been developed to account for these. It is timely to build upon our important research findings and significantly advance the state of the art in the field of mechanobiology to understand osteoporosis aetiology and ultimately inform effective therapies.A particular challenge for the international research field, has been that most current understanding of bone biology and pathophysiology has been derived either using 2D cell culture, which fails to capture vital biomechanical aspects of bone that govern bone biology, or animal studies, whose biology differs from that of humans. So, existing approaches cannot fully capture, or account for both human biological and mechanical factors, and this project seeks to address this challenge.  The global objective of the MEMETic project is to provide a paradigm change for studies of bone disease and therapeutics by consolidating, and significantly advancing, our novel approaches to develop advanced ex vivo models that recreate in vivo biomechanical cues in a living and multicellular 3D environment to replicate the mechanobiological function of bone. The MEMETic models will be applied to advance understanding of osteoporosis and a new osteoporosis therapy (sclerostin antibody). A unique multidisciplinary approach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Integrated health, social and economic impacts of extreme events: Evidence, methods and tools' under Sixth Framework.

assistant: **Concept**

Recent events such as the Pakistan earthquake, Hurricane Katrina, the Indian Ocean tsunami and the European heat waves of 2003 reveal the vulnerability of societies to extreme events. The goal of this project is to strengthen prevention, mitigation and preparedness strategies in order to reduce the health, social and economic impacts of extreme events on communities.The objectives of the MICRODIS project are to strengthen the scientific and empirical foundation on the relationship between extreme events and their impacts; to develop and integrate knowledge, concepts, methods and databases towards a common global approach and to improve human resources and coping capacity in Asia and Europe through training and knowledge sharing. This integrated project involves partners from Asia and Europe, including research, policy and ground roots institutions.The outputs will include an evidence-base on impacts, field methodologies and tools for data compilation, impact models, and integrated vulnerability assessments. It will also strengthen standardised data collection of extreme events and their impacts at local, regional and global levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Advanced silicon prototyping in reconfigurable environments'.

assistant: **Innovation**

This project will address the European need to build low volume embedded systems, quickly and cheaply. The objective of this project is to produce a One Stop" Evaluation and development kit that enables users to rapidly produce a Silicon Solution for their embedded system. It will enable smaller companies(SMEs) to invest in development tools for their RISC microprocessor based embedded systems. The tools will be competitively priced to enable SMEs to quickly develop prototypes of their systemThe results of this project will be:- an easy to use development system that will allow end users to prototype designs on a development board. - a methodology which allows those designs to be made into an ASIC How the partners intend to approach the work : The companies in the consortium will collaborate to produce a set of tools that will enable a company to embed an ARM core in a "sea of logic" and so add increased functionality to a product quickly and easily. Each partner will bring their own area of expertise to the project. ARM will provide their expertise in Embeddable microprocessor cores and supporting software. Oxford University are experts in automated implementation of hardware and software systems ES2 will produce the design in an ASIC. ARM will coordinate the project. What Will Be The Impact Of Expected Results : The board will assist extending the spectrum of ASSP/ASIC interested parties, to develop silicon designs. These parties include:- lower volume users , including those new to ASSPs/ASICs - design consultancies - s/w houses , including RTOS developers - higher volume users wanting fast prototyping / route to market"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fuel forming electrocatalysis: Devising multifunctional covalent organic frameworks with vinylenic linkage for electrocatalytic CO2 reduction and water oxidation' (COFPOR-4-fuels) under Horizon Europe.

assistant: **Objectives**

Global energy demands and increase in the utilization of fossil fuels have contributed towards rising CO2 concentration in the atmosphere, giving rise to grave environmental concerns such as the green house effect. In order to achieve decarbonization of the energy system, the European Green Deal considers the development of innovative technologies, as the one contemplated in this project, as a key point. Generation of chemical fuels by mimicking photosynthesis is a promising technique. The significance of plant photosynthesis to convert CO2 with H2O into carbohydrates and O2 by sunlight in a green manner is widely known. Artificial photosynthesis is expected to efficiently mimic this process for reducing CO2 with H2O as electron donor, that is, integrating CO2 reduction reaction (CO2RR) and H2O oxidation half reactions in one catalytic system. Electroreduction of CO2 into value-added fuels is of significant importance but remains a big challenge because of poor selectivity, low current density, and large overpotential. Crystalline porous covalent organic frameworks (COFs) are promising alternative electrode materials for CO2RR owing to their tunable and accessible single active sites. This proposal aims at introducing a new class of COFs based electrocatalysts to rationally explore the use of heterogeneous electrocatalysts offering both chemical tunability and stability in harsh reaction conditions. The development of an electrocatalytic model system is proposed herein, which will be meticulously executed via strategic synthetic protocols and optimized by solid-state chemical procedures and crystal engineering so as to provide insights into the architecture of the COFs, reactive intermediates and mechanistic steps involved in the electrocatalytic process.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mapping the functional connectome for speed control in spinal motor circuits' (FunCoSpeedSpine) under Horizon 2020.

assistant: **Objectives**

The study of spinal circuits underlying locomotion has a rich history, spanning over 100 years of research. Great efforts have been made to map out the connection patterns between motor neurons and different muscle targets. Yet, we know little about how premotor networks govern the recruitment of motor neurons and the control of speed. Recent advances in optogenetics, 3D light patterning and fluorescent-targeted patch clamp recordings of identified neurons now enable to map the functional connectome for speed control in spinal motor circuits. Here we will focus on the role of V2a excitatory premotor interneurons since these cells have the potential to act as a key nexus in the spinal network: i) spanning both in the hindbrain and spinal cord, ii) making direct connections with motor neurons and iii) modulating locomotor speed. Recent studies revealed piecemeal information related to the V2a to motor neurons connection pattern. By taking advantage of the optical clarity of the zebrafish larva, we will implement a comprehensive approach combining in vivo electrophysiology, state-of-the-art 3D optical stimulation of genetically targeted cells and functional calcium imaging to resolve the connectivity map of V2a neurons and answer 3 new key questions:1. What are the synaptic connections among V2as and between V2a and motor neurons within both slow and fast locomotion?2. What is the degree of convergence and divergence between V2a neurons and motor neurons? 3. Do supraspinal inputs to the spinal cord segregate based on speed?A talented young scientist, with a great track record and the right expertise to tackle these ambitious questions, will carry out the project in the prolific research environment offered by the Wyart lab at the Brain and Spine Institute in Paris. This ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Vertically stacked memory cells based on heterojunctions made of hybrid organic/inorganic materials'.

assistant: **Objectives**

The use of three dimensional structures for the realization of non-volatile-memories requires that bit storage and selection elements can be stacked up vertically and should therefore be both manufactured in the Back End Of the Line. Silicon is not well suited as a back end semiconductor material, because the high thermal budget required for both deposition and dopant activation, makes its integration with most of the bit storage elements materials impossible. One of the NVM that appear quite promising are those based on cross-bar architectures. Such an architecture allows an increased miniaturization given a certain lateral feature size since they can be  vertically stacked. In addition the cost per bit of such an architecture is significantly lower than the conventional CMOS based ones, since the number of photolithographic masks necessary to produce them is lower.In this project we will integrate junction made of II-VI and organic/polymeric semiconductors into cross-bar type memories to obtain a scalable cross-bar non volatile memory with both bit storage and selection elements vertically stacked on on top of the other.  The junction material should require a low thermal budget for its preparation to be compatible with the most promising technologies for the bit storage element, such as chalcogenides.The objectives can be summarized as follows:-Making Schottky and p-n type heterojunctions able to stand high currents and with an high Ion/Ion(1/2) able to operate at low voltage.-Demonstrating the integration of cross-bar architecture, made of a junction based on II-VI and/or polymeric semiconductors and a storage element, up to a 100x100 nodes -Demonstrating the scalability of vertically stacked array junctions for memory application by means of e-beam lithography up t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Automated speciation analyser'.

assistant: **Innovation**

Speciation (determination of chemical species) of trace elements plays an important role in ensuring the quality of life in terms of consumer protection, health and safety, and protection and the environment, and has to be established in routine analysis of environmental samples. All existing analytical methods applied to metal speciation are extremely time-consuming and costly and require a highly trained staff, which results in an indispensable demand for the development of a simple and robust system, specially designed for speciation analysis.The aim of the project is to develop an instrument capable of prodiving information on speciation of environmentally interesting elements on a routine basis. The instrument is intended to be based on a combinationn of a pure-and-trap concentrator, an isothermal oven housing a capillary GC column and a miniature microwave-induced plasma torch for the excitation of the analytes. With the use of a specially designed emission detector, this technique shall allow the determination of species at the trace and ultratrace level. The instrument is intended to be marketed with an user-friendly chemistry kit, including a set of recipees for metal speciation in a variety of environmental matrices.According to the planned working plan each hardware compound is proceeding. First results for the pure-and-trap unit, the GC system, the plasma, as well as the detector have been obtained. Each component on its own has been tested for its suitability, so the next step is to connect them to a complete analytical instrumentation. Furthermore, a strategy has been established and first results have been obtained for the analytical procedure for the determination of species in different matrices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Defining the Russian contributions to the Barents sea impact study' (BASIS), addressing dissemination and exploitation.

assistant: **Impact**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.