RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Defining the molecular basis of type 2 diabetes predisposition through targeted sequencing of the CREBBP-interacting gene network'.

assistant: **Concept**

Type 2 diabetes (T2D) represents a major challenge to global health. In recent years, over 60 genetic loci have been confidently implicated in T2D predisposition: however, there has been only limited progress in defining the biological mechanisms responsible. Recent work led by the host institution has revealed that these T2D-associated loci are substantially enriched for genes whose protein products interact with CREBBP, identifying this transcriptional co-activator as a key node linking processes involved in T2D development. The research I propose to conduct aims to explore the overall contribution of the CREBBP interactome in T2D predisposition, through integration of existing and novel genetic data. The former is provided by extensive genome wide association (n~100,000 individuals), exome sequence (n~14,000) and exome chip (n~60,000) available to the host institution; the latter will be generated by the applicant through large-scale (>20,000 individuals), targeted resequencing of genes coding for key CREBBP-interacting proteins. Through these data, I expect to generate a comprehensive evaluation of the genetic evidence linking CREBBP-interacting proteins to T2D pathogenesis, laying the foundation for further functional studies. As well as the intrinsic scientific merit of this proposal, the research outlined will provide extensive training in state-of-the-art experimental and analytical methods in human genetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Advanced Identification of Atmospheric Compounds' in the context of a Horizon Europe call.

assistant: **Objectives**

Global warming and air pollution are urgent challenges facing humanity. Atmospheric aerosol particles contribute to both by affecting air quality, cloud formation, and the absorption and reflection of sunlight. Increasingly, the atmosphere is shaped by organic rather than inorganic chemistry. While initiatives like the European Green Deal have reduced inorganic emissions, volatile organic compounds (VOCs) from biogenic and anthropogenic sources are on the rise. These VOCs react to form oxidized compounds that drive aerosol particle formation. Understanding the molecular processes leading to particle formation is crucial for tackling climate change and improving air quality, with accurate compound identification being a key component of this effort. However, atmospheric science currently lacks the tools and infrastructure to identify most compounds in aerosol samples collected in field campaigns. The main challenge is the absence of reference standards for atmospheric compounds in mass spectral (MS) libraries, which are needed to match unknown spectra with known references. Experimentally creating such a library is difficult due to the lack of reference samples and the large number and reactive nature of atmospheric compounds.Through CLOUDMAP, I will address these challenges by creating an MS library using computational methods. I will develop a comprehensive dataset of mass spectra of pure atmospheric compounds via simulations, alongside a machine learning tool for enhanced compound identification. This tool will be used to identify unknown compounds from aerosol samples collected during field campaigns. By integrating quantum chemical MS simulations, machine learning, and atmospheric science, CLOUDMAP will advance the digitization of atmospheric chemistry, improve the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Early Exploitation of Cetacean in Western Europe during the Late Upper Palaeolithic', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Whalebone project builds upon new advances in the study of past human adaptations to coastal environments, focusing on a key case study: early interactions between Late Upper Palaeolithic foragers and cetaceans at the end of the Last Glaciation in Western Europe. Over the last decade, a growing body of evidence suggests that the exploitation of whales could have been one of the significant factors underlying the development of early coastal economies during the Magdalenian culture, between 18,000 to 15,000 years ago. The recent identification of 54 whale bone artefacts in the Cantabrian region (northern Spain) during the previous postdoctoral research of the PR, to which can be added the 109 previously known Pyrenean examples, revealed the existence of regular and structured communication networks for the long-distance circulation of these marine resources. However, these studies focused only on the Bay of Biscay and it is still unclear whether this phenomenon was a strictly local adaptation or was part of a wider, shared coastal economy connecting different parts of Europe. To test this hypothesis, Whalebone proposes to identify cetacean bone objects outside the Pyreneo-Cantabrian region, focusing on the Spanish coasts. As many Magdalenian sites are close to the paleo-shorelines that yielded rich osseous industries, the Mediterranean coast is a particularly crucial area of investigation. Direct (dolphin bones) and indirect (whale barnacles) evidence for the exploitation of cetaceans in its southern part confirms the early interest and management of marine mammals. A multi-proxy approach beyond traditional zooarchaeology, including the first use of an innovative ancient proteomic technology (ZooMS), together with a minimally invasive dating program of cetacean bone
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LIVING INNOVATION - Implementing RRI through co-creation of smart futures with industry and citizens', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the LIV:IN project, major industry leaders from the ICT sector join forces to co-create more responsible approaches to innovation for the first time. LIV:IN builds on the premise that recognition of the value of RRI among industry is necessary for achieving the aim of the call “to progress further in integrating RRI in industrial contexts”. The project follows an opportunity oriented approach in order to (1) activate industry leaders, experts and citizens to experiment with responsible ways of co-creating innovations; (2) build capacity for RRI implementation and develop tools that are applicable across industry sectors; and (3) transform attitudes towards RRI from risk to opportunity.LIV:IN will demonstrate the added value of RRI in the area of smart future living. We carefully selected this application area because it directly impacts the lives of citizens (societal relevance) but also constitutes a major emerging market (business opportunity). The project includes four key features that will significantly enhance the quality of the proposed coordination and support activities. First, six LIV:IN Labs and a virtual community of practice will constitute the central spaces for experimentation with integrating RRI in industry, and, consequently, the development of new approaches to innovation. Second, the application and continuous improvement of RRI tools in these spaces will contribute to capacity-building among industry and citizens alike. Third, embedded audio-visual story-telling will be the main vehicle for disseminating results and for shifting attitudes towards RRI from risk to opportunity. Finally, continuous dialogue with earlier and present initiatives in the areas of RRI, CSR and open innovation will ensure the transferability of project results across indu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Portable EEG-based screening of social predispositions in newborns' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Predispositions to preferentially orient towards cues associated with social partners, such as face-like stimuli or biological and animate motion, appear to guide human social behavior from the onset of life and are typically impaired in children with autism-spectrum disorders (ASD). An early detector of social predispositions and their impairment in newborns might provide a valuable biomarker for ASD, an indicator of utmost relevance since infants with ASD greatly benefit from early behavioral intervention. This proposal builds on a study performed within my ERC grant in which, by designing an innovative oscillatory visual presentation of face-like patterns and perceptually equivalent controls, we identified an EEG-based index of face processing, present in each newborn tested and obtainable with less than 2 minutes of newborn’s visual attention. However, recording newborn’s EEG is currently possible only in laboratory settings, as no fully portable EEG system adapted for newborns exists in the market. The goal of this proposal is to design a portable, wireless EEG-based device that allows easy, rapid and automatic testing of face processing in newborns in any context, including their homes. This device is ground-breaking because it will combine the efficacy of our innovative experimental paradigm tailored to newborn’s restricted visual attention with a portable, low-power, wireless EEG device based on dry electrodes and an automatic algorithm that will extract on-line the EEG-based index of face processing. Its realization will enable the development of an early, objective and easy-to-test EEG-based biomarker on newborns at risk, potentially opening the way to large-scale screening protocols. Given the flexibility of the paradigm with respect to the content of the vis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the developmental origins of parallel evolution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The diversity of life may seem endless. Yet, a closer look reveals that evolution often is on repeat. This is most striking when the same suite of characters evolves over and over again. One explanation for such parallel evolution is that development produces some phenotypes readily and frequently, while others are rare or impossible. Evolution must go where development leads.   I have identified a rare opportunity to put the role of development in adaptive evolution to the test. At least six species of wall lizards have repeatedly evolved a complex syndrome, including striking coloration, stout bodies, large heads, and aggressive behaviour. All these traits develop from the same cell type, neural crest cells. I propose that this developmental coupling allows seemingly unrelated traits – colours, morphologies and behaviours – to vary together. As a result, variation is channelled down particular routes, resulting in parallel evolution. I will test this hypothesis by establishing ‘Evo-Devo 2.0’ – merging evolutionary and developmental biology in a comparative framework. Firstly, I will reveal if independent origins of the syndrome share the same transcriptional and epigenetic modifications of neural crest cells. Secondly, I will identify how parallelism at the phenotypic level is mirrored at the genomic level. Thirdly, I will use gene editing to functionally validate the results and reconstruct the evolutionary steps at the origin of the syndrome.   If my hypothesis is correct, my insights will demonstrate that understanding development enables us to make evolution more predictable. Failure to attend to the arrival of the fittest has left us poorly equipped to predict how invasive species evolve, or if species will adapt to environmental challenges. My research will fill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Inhabited spaces for community, academy, polity and economy' to be submitted under Fourth Framework.

assistant: **Abstract**

Specific aims include:- A reconsideration of current notions of the user interface and its extension to support social participation between users rather than didactic patters of interaction with computer systems.- Developing novel interaction metaphors and techniques which seamlessly combine information visualisation and access with social interaction.- Reconsidering the notion of users of computer systems to allow them to become inhabitants of electronic spaces.- Developing techniques for integrating electronic spaces with physical spaces including notions of shared augmented reality and shared augmented virtuality.- Developing techniques to support very large-scale and heterogeneous systems - Extending intelligent agents towards being inhabitants of social computing environments.- Developing the necessary network and software infrastructure required to deliver these kinds of applications on platforms which will be available to the general citizen within a few years.- Gathering experiences with the development, deployment and use of this kind of application as well as new methodologies for eliciting requirements and for carrying out evaluations.- Gaining a greater understanding of the social, cultural and economic impacts of such applications.Existing information systems adopt an individual perspective of use and assume that interaction is principally between a single user and a application. In contrast, INSCAPE addresses the need to extend such systems to provide greater support for social participation involving a number of users. The schema investigates the development of new spatial interaction techniques using technologies such as distributed virtual reality to transform current information systems into future social information spaces.The increased prominence of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Printed temperature sensitive labels for products in cold chain' (2014-2020) under Horizon 2020.

assistant: **Objectives**

T-Sense Cold represent the series of irreversible temperature-sensitive colour-changing labels for package in cold supply chains. Organic composites containing color former, color developer and co-solvent are used in these inks to define the temperature where the color changes between colored (black, blue, magenta, red) and discolored. Such composites are usually protected in microcapsules and applied in an appropriate binder system to obtain printing ink that changes color reversibly when heated/cooled across the activation temperature (TA). Our innovation starts here – we realize the irreversible (permanent) color change by re-combination of similar substances using advanced chemical engineering. Below TA the new ink is white and permanently colors above TA. The color change is activated in the cold chain environment, e.g. at the packaging of temperature-sensitive food. Two types of activation are planned, contact - for small series and noncontact for large series. Both activation possibilities are our innovations for applications in the cold chain.Why is this important? Because each producer that enters cold chain should count at least 10% of the turnover as a waste due to lack of control in the chain! Here we are dividing the responsibility among all actors across the supply chain and empower producers to increase the level of control in production. This problem is our business opportunity. We have started MyCol company as a spin-off from National Institute of Chemistry, Slovenia. We produce innovative labels, new at the global level, applicable to any reasonably smooth surface, low-cost, needing no energy supply, which show temperature changes in the cold chain with the naked eye (or by video camera). The market size for the cold chain is huge and increases with hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Self-Organisation and Learning Online in Mobile Observation Networks'.

assistant: **Innovation**

Smart cameras are embedded devices combining a visual sensor, a processing unit and a communication interface, allowing the processing of images on the device, such that only aggregated information, instead of raw video data, is transmitted. Smart camera networks are typically used for large-scale high value security applications such as person tracking in airports or amusement parks. However, current smart cameras are expensive and have only very limited mobility, acting as a barrier to their wider adoption. The SOLOMON project is driven by the rising demand for rapid-deployment camera networks which can adapt to provide security in the context of unforeseen situations and unfolding scenarios. This is evidenced by the rapid growth of leading body-cam company Edesix Ltd, whose VideoBadge technology is being adopted by police forces worldwide . However, recent research advances in smart camera networks have not yet been realised in dynamic body-worn camera networks, and still rely on prohibitively expensive static hardware. In the SOLOMON project we envision a novel type of lightweight, inexpensive smart camera network suitable for rapid deployment and reconfiguration, where low-cost camera devices such as Edesix’s VideoBadge, are paired with the processing capabilities of smartphones. These are then worn by people (e.g. police, security guards) or mounted on mobile robots. This not only lowers cost, but allows us to introduce a feedback loop between the sensing cameras and the acting people/robots, enabling the camera network to adapt to changes during runtime, for example to prioritise or cover newly relevant areas sufficiently. Novel techniques in collective decision making and self-organisation as well as multi-objective online learning will need to be developed, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stepping forward in understanding the  Metabolic Cost of Human Walking' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The mechanisms underlying metabolic cost of walking are unclear. This is important not only because they provide fundamental insight in human movement, but they are also essential to reduce increased cost of walking in the elderly and impaired. To understand these mechanisms, it is required to know the link between energetics at the human level and the energetics at the muscle level. Whereas the energetics at the human level is experimentally accessible, that at the muscle level is not. Current estimations greatly overestimate actual metabolic cost and hence there is no basis understanding metabolic cost of walking. In this project I will first ever directly measure oxygen consumption of dynamically contracting muscle fibres. These experiments will be conceptually linked to in vivo experiments measuring oxygen consumption during isolated movements as well as during walking. Using these data and state-of-the art optimization techniques applied to detailed neuro-musculoskeletal models I will link energetics at the muscle level to that of a walking human and provide insight in the mechanisms underlying the metabolic cost of walking. This grant would allow the applicant to return fully to a EU research environment and would have a very significant and direct impact on my career perspective.