RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Real-time Content Analysis and Processing (ReCAP) for Agile Media Production', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The media production industry is rapidly evolving and expanding globally, primarily driven by the explosion in mobile devices such as phones and tablets, the ubiquity of internet access and the subsequent demand to consume content anywhere, at any time and on any device.Modern media production workflows must thus be agile and support multiple heterogeneous sources and playout targets in a responsive and cost-effective way. This poses challenges for quality assurance and Media Asset Management (MAM) where access to rich metadata and data integrity are essential.Today, these challenges can only be addressed by enterprise and high-end solutions used by major public and private broadcast companies; solutions which are highly proprietary, extremely costly and complex to implement for the large number of small to medium sized creative companies, small broadcasters and corporate teams responsible for producing audiovisual content for broadcast, video on demand, web and mobile consumption.This proposal aims to take recent technology research results from automatic real-time content analysis and processing and bring-to-market an affordable, integrated, scalable, open commercial software solution. It will include the automated extraction of metadata (e.g., detection of logos, faces, temporal segmentation, visual similarity) for use in media asset management and the analysis of the visual quality of the content and automatic tools for reducing or repairing quality impairments.The algorithms will be implemented as modules that can be integrated into real-time analysis pipelines, as well as batch processing for non-real time workflows and can be deployed locally or scaled as cloud-based services.


**Keywords:** real-time content analysis, video processing, media asset management, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The first global peer-to-peer platform for government, to help public servants find the ideas, experts and partners they need to solve today’s hardest challenges' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

OECD countries spend around 40% of GDP on government, i.e. $30 trillion globally; $6 trillion in the EU. Yet the policies thatgovern the allocation of these vast sums are often made haphazardly, without looking around the world to see what’s workedand what’s failed – at great cost to society.Apolitical Group Limited was founded in 2015 in London, UK, by two experienced entrepreneurs: Lisa Witter and RobynScott. The company now has 22 employees, with a subsidiary in Belin. We have developed a web-based platform calledApolitical (TRL7) which went online in June 2017. It is the first of its kind global policy insights peer-to-peer platform whichaddresses the $8 trillion global public-sector procurement market. It has reached more than 30 million people with its policycontent; and its private network is used by more than 16,000 policymakers in more than 140 countries.Through the SME Instrument Phase 2 project will upscale the TRL7 platform into a fully featured version which, along withother new features, includes a subscription-based community and marketplace serving governments, policymakers andbusiness. We will target the public sector market in OECD countries comprising 8M civil servants, including 3M potentialusers for our subscription product. Our main private sector target market is GovTech SMEs, i.e. those with tech-enabledproducts selling to government.Our project team, led by our CEO Ms. Robyn Scott, has a strong track record in project management, marketing, finance,fundraising, leadership, and technology.


**Keywords:** machine learning, peer-to-peer learning platform, public sector, public servants, governments,  govtech, civictech, SMEs, policy and procurement innovation, societal trust building, global, governance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Myasthenias, a group of immune mediated neurological diseases: from etiology to therapy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Myasthenia Gravis (MG) is a heterogeneous rare autoimmune neurological disease affecting the neuromuscular junction (NMJ). The molecular events causing and maintaining MG are still unknown and current treatments do not lead to remission and entail considerable side-effects stressing the need for improved therapies. We will address the: 1. Natural course of disease: determine factors associated with disease onset and/or affecting the course of disease and patients' quality of life in subgroups of MG patients including children, twins, females and elderly patients. 2. Etiology of MG: identify new genetic, epigenetic and environmental risk factors and investigate immunological key molecules associated with MG onset. 3. Pathogenic mechanisms at the NMJ: a) study molecular changes in the NMJ by proteomic, genetic, epigenetic and microRNA analyses in MG patients and experimental models; b) analyze morphological changes at the NMJ in mouse models expressing YFP nerves and mice transgenic for mini-agrin; c) evaluate the capacity of muscle cell satellites from MG patients to regenerate muscle and form new endplates in immunodeficient mice. 4. New diagnostic and monitoring assays: a) identify pathogenic and protective factors in MG sera; b) improve the sensitivity of current assays; c) Identify new biomarkers associated with different MG subgroups by proteomic and microRNA analyses; d) Identify patients' response to treatment and liability to side effects by pharmacogenomic analyses. 5. Novel therapies: a) study new cell-based therapies aimed at regulating the autoimmune response by regulatory T cells or mesenchymal stem cells in humanized mice; b) immunoadsorb pathogenic antibodies; c) test non-cell based immmunomodulatory therapies; d) target epigenetic regulators. This multidi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Satellite Processing By Artificial Intelligence - Enabling Satellite Analytics' to be submitted under Horizon Europe.

assistant: **Abstract**

BUSINESS NEED. Climate change leads to infrastructure disruption, food insecurity and global losses and hence, does directly affect safety and security of people. Nowadays, when an event occurs emergency protocols are activated, and damages are evaluated in the following days. There is a need of having vulnerability assessment information, before the event occurs to know where the most vulnerable area, asset or population is. Knowing the most vulnerable point and its dynamic evolution (where the impact will be worst) is a key information to generate an adaptative answer to climate extreme events and minimize socio economic damages.However, current impact analysis methods are semi-automated, limiting the speed, coverage and number of analyses that can be done. Our solution, interoperable, fast to deploy and easy to use, is based in the analysis of different data sources such as Copernicus (Satellite data), Meteo patterns and OpenData.MARKET OPPORTUNITY. During the last decade thousands of satellites have been put in orbit creating the new space economy. The total amount of investment done just in Copernicus Satellites amounts to 8,2 Billion. In addition, according to Space Capital  the total equity investment over the last decade in the space economy was €177.7 billion. However, the penetration over different industrial markets is very low , putting at risk the Return of Investment (ROI).EARTHPULSE GOAL. Artificial Intelligence (AI) is the transformational technique of our era. Satellite data, and in particular, Earth Observation (EO), will greatly benefit, as other areas, from its application by lowering the cost of adoption and accelerating market uptake. Our company goal is to accelerate the market uptake of EO data with AI.At EarthPulse we are working hard on overcom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Rejuvenation of the Intervertebral Disc Using Self-Healing Biomimetic Extracellular Matrix Biomaterial Tissue Adhesives'.

assistant: **Objectives**

Lower back pain is a global epidemiological and socioeconomic problem. This project envisions a future whereby patients with degenerated intervertebral discs are injected with a self-healing biomimetic adhesive biomaterial which can restore both the biochemical and biomechanical properties to native tissue levels. Current surgical procedures do not replace herniated tissue from the central nucleus pulposus or repair the annulus fibrosus (outer ring of tissue), which can lead to accelerated degeneration, reherniation and recurrent pain. Spinal fusion, whereby the compromised or degenerated tissue is removed, and the vertebral segments are fused together, does not restore biomechanical function leading to degeneration of adjacent discs with long-term failure rates as high as 40%. My lab has developed a biomimetic injectable hydrogel (iDISC) consisting of the main components (collagen and chondroitin sulfate) of native disc tissue that can be tailored to match the biochemical and biomechanical properties of native disc tissue. In addition, the iDISC hydrogel demonstrates self-healing and adhesive properties to facilitate tissue integration and exhibits excellent cell biocompatibility. The objective of this proposal is to perform in depth in vitro characterisation (WP1), multiaxial biomechanical testing (WP2), pre-clinical evaluation (WP3) and marketing and commercialisation evaluation (WP4). The development of these injectable biomimetic hydrogel systems may facilitate earlier interventions aimed at halting the degenerative process, restore natural biomechanical function, enhancing patient accessibility, improving quality of life, reduce healthcare expenses and lost productivity in the European Union. The platform technology and knowledge generated through this research ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Seamless Integration of Neurons with CMOS Microelectronics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

We propose to seamlessly integrate advanced microelectronics and living neuronal cells in a comprehensive and interdisciplinary approach to significantly advance the understanding of neuronal behaviour. The project includes (a) the development of a novel multifunctional microelectronics chip platform in complementary metal oxide semiconductor (CMOS) technology, which serves to enable (b) key neurobiological and neuromedical research on network dynamics and plasticity of rodent neuronal networks and visual encoding in retinae, and (c) the necessary concurrent development of algorithms and models to efficiently process and maximally harness the unprecedented quality of the obtained data.Neuronal or retinal preparations, such as acute and organotypic brain slices (retinae) or primary cultured, dissociated cells, will be directly placed or grown atop dedicated CMOS microelectronics chips. The chips will feature multiple functions, since neurons carry and pass signals to each other using electro-chemical mechanisms: electrophysiological recording & stimulation, in closed loop & real time, as well as highly spatially resolved impedance measurements and detection of neuroactive chemical compounds. The chips will be capable of delivering any of these functions to arbitrarily selectable individual cells or even subcellular units, and, at the same time, of interacting with a multitude of cells or complete neuronal networks. Along with imaging (light, fluorescence), pharmacological, and/or genetic methods, the developed chip platform will be used to study neuronal network dynamics, synaptic and axonal plasticity, relevant for many brain diseases, as well as visual encoding in the retina. Efficient data handling and spike sorting algorithms will be developed to facilitate these inv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unraveling the consequences of early cerebellothalamic dysfunction and its role in autism spectrum disorder symptoms' under Horizon 2020.

assistant: **Concept**

Cerebellar abnormalities are consistently reported in autism spectrum disorder patients, however the cerebellar contribution in the etiology of this pathophysiology remains poorly understood.It has been proposed that the cerebellum may drive the maturation and functionality of cortical high-order structures involved in the core symptoms of autism. However, the mechanisms by which the cerebellum could control these processes remain to be determined. The neural circuits linking cerebellum with the cerebral cortex via thalamic relay stations are the anatomical scaffolds underlying the cerebellar cognition. Recent data have shown that the thalamus plays a key role in the reorganization of cortical areas after early sensory deprivation. Therefore, during early development, abnormal cerebellar inputs to the thalamus may contribute to cortical dysfunctions that could lead in high-order deficits. However, despite being autism a neurodevelopmental disorder, any study has addressed the analysis of cerebello-thalamo-cortical circuits from a developmental perspective.The present project (UNCERTHAIN) offers an exceptional opportunity to shed light onto this issue as a result of the unique combination of approaches. Accordingly, we will use an experimental model that offers the possibility to embryonically alter the cerebellothalamic connectivity and thus, study the mechanisms underlying the events that influence the normal development and functioning of cortical circuits. Hence, we will adopt both multidisciplinary and innovative approaches to characterize the thalamocortical network in presence of a disrupted cerebellar input, the functional consequences and its relationship with autistic-like behaviors.The successful execution of this high-risk, high-impact research will provide i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developmental Speed of Species-Specific Thalamocortical Synchronization' (NEUROSYNC).

assistant: **Innovation**

Developmental timing in brain formation has traditionally been studied independently across regions; however, spatial and temporal synchronization between regions is essential for the formation of functional neural circuits. In humans, the cerebral cortex develops slower, allowing for the formation of complex circuits that enhance cognitive abilities. Yet, not all brain regions follow the same developmental pace. The thalamocortical system, in particular, shows accelerated synchronization in humans, with thalamic connections reaching the subplate and cerebral cortex at early neurogenic phases. This early synchronization suggests a unique human specialization that remains largely unexplored. Such divergence may offer an extended window for distinct specializations to arise, facilitating cellular diversity and complex circuit formation, key drivers of evolutionary advantage. This raises the intriguing possibility that the thalamus, a subcortical structure, plays a critical role in driving novel specializations within the human subplate and cortex earlier than thought. Here, I aim to uncover the fundamental principles governing species-specific synchronization and developmental timing in the thalamocortical system, and their impact on human brain development. To achieve this, we will generate novel human stem cell-derived models replicating the self-emerging properties of thalamic-subplate communication. By employing multi-omic comparative approaches, we will investigate human-specific specializations and diversification of subplate dynamics, while exploring the consequences of disrupted synchronization in human and mouse models. In sum, our work will reveal the molecular and cellular consequences of accelerated thalamic-subplate synchronization in human development. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Assessing the role of Multi-Agent Coordination and Control as an independent engineering discipline' (MAGECC) targeting Fifth Framework.

assistant: **Abstract**

Coordination and control is a research domain whose potential is growing continuously with the ever-increasing penetration of computers, sensors, actuators, communication and software in the artefacts we develop. Moreover, coordination and control are intrinsic to human society just as speech, vision and natural language are. Agent technology is widely considered to be a most promising candidate for addressing the challenges in this research domain in a generic manner. The proposed assessment project aims to establish whether it is possible to develop generic coordination and control functionality and support across a wide range of application domains based on multi-agent technology. The project assesses whether sufficient grounds exist for establishing multi-agent coordination and control as a technology domain (like the domains for vision, natural language and speech, which already exist today).OBJECTIVESThe proposed assessment project aims to establish whether it is possible to develop generic coordination and control functionality and support across a wide range of application domains based on multi-agent technology. The project assesses whether sufficient grounds exist for establishing multi-agent coordination and control as an independent technology domain (like the domains for vision, natural language and speech, which already exist today).DESCRIPTION OF WORKThe project distinguishes:1. Reference application domains, in which the consortium has expertise and in which a significant level of know-how is available. These are motion control and manufacturing control;2. Target application domains, which are socio-economically important.This set of domains contains traffic coordination and control as well as the coordination and control of advanced energy suppliers and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular, cellular and metabolic neuronal pathways of Fragile X Syndrome' to be submitted under Seventh Framework.

assistant: **Abstract**

Mental retardation (MR) is a major cause of serious handicap, as well as an important medical and social issue, affecting 2-3% of the population. The Fragile X Syndrome (FXS) is the most frequent hereditary cause of MR affecting 1/4000 males and 1/7000 females, due to the inactivation of the X-linked Fragile X Mental Retardation 1 gene (FMR1). In FXS patients and the Fmr1 knock-out mouse, the lack of the gene product, the RNA-binding protein FMRP, induces behavioural and cognitive abnormalities, coupled to alterations of synaptic plasticity and morphology, most probably due to alterations of the transport and localized synaptic translation of specific mRNA targets of FMRP. To better understand the role played by FMRP in this processes, I propose to first systematically identify the mRNA specifically targeted by FMRP in RNA granules, the mRNP particles that transport mRNA towards the synapse, using a transcriptomic approach. In addition, I will identify the protein partners of FMRP in the neuronal RNA granules, using mass-spec analysis of the proteins coimmunoprecipitated with FMRP in biochemical preparations of RNA granules. Finally, I will use proton nuclear magnetic resonance spectroscopy (1H NMR) and multivariate pattern recognition to characterize the neurochemical perturbations and define a metabolic signature of FXS in Fmr1 KO mice, that will further enable a pharmaco-metabonomic study of FXS treatment efficacy. This project will essentially be developed at the IPMC, in Dr Bardoni's laboratory (Aim 1 and 2) but also in close collaboration with a Canadian laboratory (Prof. Khandjian, Univ. Laval, Québec) and with a French laboratory (Aim 3, Dr Dumas, ENS Lyon) and. By integrating the molecular and metabolic data obtained following this trans-disciplinary approach,