RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The molecular universe: an interdisciplinary programme on the physics and chemistry of molecules in space' (2002-2006).

assistant: **Concept**

Molecules are an important component of the universe which dominate the cooling and degree of ionization of interstellar gas clouds and, hence, regulate star and planet formation. The exploration of paths towards chemical complexity in space has direct bea ring on the origin and evolution of life. Moreover, molecular transitions provide a sensitive probe of the dynamics and the physical and chemical conditions in a wide range of objects at scales ranging from newly formed planetary systems to galactic and ex tragalactic sizes. Near-future large scale observatories by the European Space Agency and the European Southern Observatory - in partnership with American and Far-East organizations - will open up the universe to high spatial and spectral resolution studie s of molecules and, hence, the study of the key astrophysical and astrochemical processes involved in the formation and evolution of planets, stars, and galaxies. These new missions will lead to a multitude of molecular line data in a variety of astrophysi cal environments. Identification, analysis, and interpretation of this data in terms of the physical and chemical characteristics of the astronomical sources and the origin and evolution of the molecular universe will require a concerted effort by physicis ts, chemists, and astronomers in the areas of molecular spectroscopy, collisional excitation processes, chemical reactions, and astronomical modelling on species of astrophysical relevance. The results of this expert effort need to be made easly accessible to the scientific community through web-based data archives. The Research and Training Network on the Molecular Universe provides a cohesive framework for the training and development of researchers in the early stages of their career, combining European res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Securities markets, international financial centres, and regional resilience. A comparative analysis of Luxembourg and Singapore as strategic nodes in investment funds’ global production networks'.

assistant: **Objectives**

Ruptures like the recent global financial crisis are inherent elements of the present “securitised financial system” (Wójcik 2011), with the asset management and investment fund industry being among the main drivers. International re-regulation challenges the competitiveness of international financial centres (IFCs) in multiple ways. By understanding ‘the local’ to better comprehend ‘the global’, a comparative study between two specialised investment fund centres, Luxembourg (EU) and Singapore (ASEAN) addresses the question, how IFCs are able to confront such discontinuities and compete by creating local resilience capacities, which go beyond regulatory arbitrages. Resilience is the consequence of the intended actions by various industrial, regulatory, or policy actors from different but linked areas of the fund ‘production’. The actors rely on localised social capital, which in a specific mode is linked to the respective global network structures in finance.The ‘geography of finance’ offers a more holistic and complementary view besides the prevalent economic manifestations on the financial sector; within this field, the global production network approach proposes a sensible heuristic to identify and analyse place-specific structures, institutions, and power relations in IFCs. Linking evolutionary and institutional economic geography concepts illuminates the dynamics of the underlying on-site inter-firm and firm-institutions’ relations, which assumingly play key roles in change processes. Consolidation processes in the maturing financial industry are having far-reaching spatial implications. The project thus aims to develop a research agenda for studying specialised IFCs and their resilience.The established and highly recognised research group in the emerging field of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intentions in Action: Establishing the neural causes of intentional action' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The neuroscientific study of intentional action has produced puzzling and contradictory results: intentions show up at a variety of brain locations, and up to ten seconds before a decision has been made. Recently, it has been argued that intentions do not underlie voluntary action at all. At the same time neural states have been found that could be correlated with future actions, suggesting a role for intentions after all. The proposed project suggests that the cause of these seemingly contrasting results lies in the heterogeneous composition of everyday actions, consisting of both immediate and future-directed components. The proposed research promises to go to the bottom of this controversy by investigation what types of actions can be accomplished without discrete states like intentions, and for what types of actions intentions are needed. It will do so by looking for common factors in brain states underlying actions using functional Magnetic Resonance Imaging. Particularly, it will be investigated whether similarity in motor acts, actions, or contexts are crucial for finding commonalities in brain states.  Next, it will be investigated whether immediate actions and future actions differ with respect to the neural control processes, thereby directly testing the applicability of a philosophical distinction to neuroscientific research. Finally, it will be assessed whether these processes are unique for self-chosen actions, or also apply to cued actions as well. This will relate the study of intentional action directly to adjacent scientific fields studying prospective memory and task sets.By solving these issues the proposed research sets out to create a novel and detailed account of intentional action which will function as a framework for future research in philosoph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Anthropogenic/natural metals and particles in polar and temperate snow/ice archives' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

My doctoral dissertation concerned the determination of a number of trace elements in dated snow and ice layers from the Arctic. Subsequently, I spent since November 1994 one year in Perth for gaining experience in isotopic analysis in the same area of glaciological research. During the proposed stay I want to expand first the results available for organolead compounds in Greenland by analysing various snow and ice samples (from now to 200.000 years ago) from central Greenland, East Antarctica and alpine mid-latitude glaciers. In addition, I intend to apply an adapted methodology for the determination of methylated organoselenium and organogermanium compounds. In a second stage I want to take part in the development of new procedures for the determination of organometal compounds with increased analytical characteristics detection limits based on the automation of the preconcentration steps and the development of novel methods of detection of the chromatography effluent with mass spectrometry detectors. In the course of my stay I will participate in the exploitation of methodologies available for microscopical characterization based on electron microprobe analysis and ion miroprobe analysis with dynamic and static secondary SIMS on particles collected from dated snow/ice layers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next Generation Nano-engineered Thermoelectric Converters - from concept to industrial validation' (NEXTEC), addressing dissemination and exploitation.

assistant: **Impact**

Global energy uncertainty and the limited recourses coupled with increased energy needs fuels the search for improving the efficiency of energy conversion technologies. Although the EU policies target increased use of renewable energy to 12% of gross energy production by 2010, this commitment has also highlighted the urgent need for improving the energy utilization of fossil-fuel based power-plants to allow continuation of the energy intensive lifestyle of EU countries.Thermoelectric (TE) devices can play a very important role in efficient energy harvesting, and recovery. TE devices are ‘fuel-free’ solid-state devices with no moving parts and therefore are extremely reliable. TEs can harvest residual low-grade energy which otherwise is wasted. To date, their use is limited by low conversion efficiency. The key factor for improving the performance of TE applications is mainly through the development of TE materials as well as corresponding TE module/device technology and design, based on the material types, which can ensure better performance. Recent advances in nanotechnology offer unprecedented opportunities in designing and fabricating increasingly complex material architectures with controlled and hierarchical microstructures. Theoretical predictions showed that low-dimensional TE materials with figure of merits (a measure of the goodness of TE materials) can be spectacularly enhanced from currently ~1 to extremely high values of 5 -10 (up to 20). The present proposal is concerned with applying modern nanotechnology principles to the design and creation of novel material architectures with enhanced TE properties, with close feedback with theoretical studies. The material architectures considered in this proposal are chosen based on suitability for the development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons'.

assistant: **Objectives**

Proper wiring and connectivity of the central and peripheral nervous system requires that during embryonic development neurons migrate and extend in the correct directions to connect to their targets. Defects in the neuronal navigation machinery lead to a variety of neurodevelopmental disorders such as Hirschsprung’s disease, Kallmann syndrome, ACC and has been associated with autism spectrum disorders and epilepsy. Neuronal navigation relies on a structure at the tips of neuronal extensions, termed the growth cone which is able to detect gradients of guidance molecules (chemotactants) secreted by cells at a distance. The chemotactant netrin, which binds multiple netrin receptors, can switch between attracting and repelling growth cones, a property which helps neurons change directionality upon reaching an intermediate target.While it has been demonstrated that this is related to the complement of netrin receptors expressed by the neuron, it is unclear how different receptor combinations trigger opposing directional responses within the growth cone. It was recently shown that aberrant expression of netrin receptors in cells that don’t normally express it cause aberrant migration of neurons, which might explain some of the symptoms associated with neurodevelopmental disorders such as Mowat-Wilson syndrome. This proposal aims to understand at the molecular level how netrin can both attract and repel neuronal growth cones. This will be accomplished by mapping the interactome of both attractive and repulsive netrin-receptor complexes, and by mapping the spatial distribution and activity of proteins within actively steering growth cones, via high resolution microscopy, micropatterning and optogenetics to spatially modulate protein activities. This combinatorial approach will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Rewiring transcriptional regulation by the PRC2 complex using proximity inducing pharmacology'.

assistant: **Objectives**

Polycomb repressive complex 2 (PRC2), which incorporates repressive methyl-lysine marks on histone H3 to facilitate global transcriptional repression, is an integral epigenetic modifier in normal development. Components of this complex, especially EZH2, are hyperactive or overexpressed in a broad range of cancers, resulting in excessive silencing of tumor suppressor genes (TSGs). Moreover, cancers with defects in the SWI/SNF complex, the most frequently mutated chromatin regulatory complex in cancer, are dependent on PRC2 function for survival. While inhibition or degradation of PRC2 components have become extremely attractive approaches to cancer therapy, they still suffer from suboptimal kinetics and perturbation because they must rely on opposing epigenetic modifiers and transcriptional regulators to derepress expression of silenced TSGs. Thus, I aim to overcome this issue by leveraging the cancer driver itself to derepress silenced TSGs. In this regard, I will utilize a high-throughput protein recruitment screen, coupled to next-generation sequencing, to identify proteins (effectors) that, when recruited to PRC2, can rewire its function to directly derepress a PRC2-silenced locus. This screen will be used a base to develop novel proximity inducing compounds, which can rewire the function of PRC2. The compound that produces the strongest transcriptional derepression and anti-proliferative effects in cancer cells will then be characterized via transcriptomics, and chromatin profiling to determine its effects on endogenous gene expression. Ultimately, this study will establish a new class of PRC2 targeting compounds that will pave the way for improved cancer therapies, which both inhibit PRC2 methyltransferase activity and directly derepress PRC2-silenced TSGs.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MICROWAVE ASSISTED GAS FIRING ON A SINGLE LAYER ROLLER KILN FOR MANUFACTURE OF CERAMIC WALL TILES' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of the project is to retrofit an existing gas fired roller kiln with a microwave generator of 40 kW in the preheating zone that will produce 3% of energy needs of the kiln. This new configuration will allow an increased productivity (32%), a reduced specific consumptiom (from 12,35 kWh/m2 to 8,62 kWh/m2) and a better quality in the final product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Migration from functional methodology to object oriented methodology' (MIFTOM).

assistant: **Innovation**

Up to now, SAIT has used the standard SA/SD methodology. Under this framework, some tools were experienced in a previous ESSI project (Case with generation limited to headers and procedures declaration) but three limitations became apparent, which SAIT hopes to alleviate in the current ESSI project, and thereby improve the development costs and the reliability of the software by:- Analysis based more on objects than on functions- More code generation on both server and client, including DML SQL.- More design and code reusability.THE EXPERIMENT To achieve the aforementioned objectives, Analysis and Design will be guided by the OMT methodology (mainly along the object and dynamical axes). Code generation will be achieved in an integrated way as well on the RDB server as on the GUI client. It was required that the code for the majority of transactions (Query and Report, Insert, Modify and Delete) should be generated mostly automatically. Hence, hand coding should be restricted to complementary handling such as logging, special constraints, computations, and more complex transactions. Finding a CASE tool supporting all these requirements as well as being produced from a well known supplier proved to be difficult. Therefore, a two step process was considered. First, OMT Analysis and Design is worked out under Verilog OMT Project Partner (but with limited code generation capability). Then, the result of this step is mapped onto Oracle Case extended generation code capability (but not yet of an OMT flavour). Classes and attributes will be mapped onto the entity relations while operations will be mapped onto stored packages, and the hand coding on triggers and dedicated packages. Reusability will be considered via OMT generalisation/specialisation mechanism and mapped for the l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Agriculturally and pharmacologically ralevant structures: more efficient syntheses of polyoximic acid and cyclopropyl amino acids.' (1998-2002).

assistant: **Concept**

Polyoximic acid is a significant component of polyamine, an agricultural ant fungal antibiotic. Another class of cyclic amino acids are cyclopropyl amino acids, which are proven to be potent Dope decarboxylase inhibitors. A new and efficient synthesis for these compounds will be carried out.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'intercultural cities and collective space' (SHARINGSPACE).

assistant: **Innovation**

SharingSpace. Research on intercultural cities and collective spaceInternational migration to cities has become a critical issue in countries of the North as well as of the South affecting all aspects of urban life. Migration is a cross-cutting issue that requires a multiplicity of focuses as well as disciplines and can benefit from comparative analysis. Given that in contemporary globalized cities collective space is where the willingness of society to include or its stance to reject the other becomes manifest, SharingSpace objective is to share the understanding of perceptions, uses and provisions of public space in different EU MSs and TCs. SharingSpace general goal is the creation of a network among research centres focussing on the adequate management of international migration in cities of EU MSs (Venice; Lisbon) and TCs (Buenos Aires, Mexico City, Johannesburg,) as a critical feature of urban policies promoting social cohesion.SharingSpace specific aims are:-to enhance the research skills of researchers-to contribute to the advancement of interdisciplinary studies and comparative research on social and spatial inclusion of international migrants in urban areas.-to strengthen relations among EU MSs and TCs research centres, with the objective of developing further common activities.The Project will overcome barriers among different disciplines that curb the exchange of knowledge and persons in the academic world. The promotion of researchers’ mobility will foster interaction and fusion of different expertise and diverse perspectives for exploring the challenges international migration is posing to urban governance in different contexts. The possibility of publishing scientific articles on the SSIIM Paper Series will contribute to their curriculum development and e