RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Beyond nucleocytoplasmic transport – Nuclear pores as self-regulating valves for flux across the nuclear envelope' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Nuclear pore complexes (NPCs) are fundamental components of all eukaryotic cells. They fuse the inner and outer nuclear membranes and form channels across the nuclear envelope. Their canonical function as gatekeepers of the nucleus and facilitators of nucleocytoplasmic exchange is well established. I hypothesize that NPCs fulfil yet another fundamental function as self-regulating valves for flux across the nuclear envelope that occurs in response to mechanical stress. This yet underappreciated function may be of utmost importance to prevent rupture of the nuclear envelope and thus to protect the genomic integrity in cells that are exposed to mechanical stress. I present preliminary data indicating that NPC conformation responds to mechanical force exerted onto the nuclear envelope with dilation and constriction. Cryo-electron tomography, live cell imaging, and genetic perturbation will be used jointly with structural modelling to investigate on a holistic scale how NPC diameter and nuclear envelope tension impact on flux across the nuclear envelope. In the proposed project I will demonstrate that besides their known function as transport channels the NPCs serve an important role as shock adsorbers for mechanical stress impacting the nucleus. The research proposed here will enhance our understanding of how cells deal with acute mechanical stress which is relevant for cell migration, metastasis, mechanically active tissues and cell differentiation.


**Keywords:** Nuclear Pore Complexes, Nuclear Envelope, Membrane Biology, Nucleocytoplasmic Transport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Tibetan Army of the Dalai Lamas (1642-1959)' (1642-1959).

assistant: **Innovation**

TibArmy proposes to undertake a study of a previously unresearched subject: the Tibetan army during the period of the Buddhist government of the Dalai Lamas, known as the Ganden Phodrang, from 1642 to 1959. This government was the heir to a robust military culture with long experience in the defence of Buddhism since the Tibetan Imperial Period (7th-9th centuries); however, from its inception it decided to rely on foreign armies for its protection. On the basis of two distinctive features of this period—the creation and maintenance of the first Tibetan standing army and the limited number of the troops compared to former times—the project will explore the enduring ambivalence of the Dalai Lamas’ government towards having its own army, as well as its reasons, consequences and expressions in discourse and practice. The methodology follows a multifaceted approach towards the military in Tibet, by taking into considerations its social, economic, political, legal, religious and cultural aspects, and focussing on the multicultural and connected historical context of the Tibetan army’s evolution (foreign Mongol and Manchu armies stationed in Tibet, and the later adoption of British and Japanese military models). The research project, based on written and oral multilingual sources, is structured along 5 thematic axes: 1. A history of the army institution (17th-20th c.): social, economic and political aspects; 2. Interactions with the Sino-Manchu troops and other foreign influences on the Tibetan army; 3. Cultural and discursive aspects: integration of the army within the Buddhist frame; 4. Material culture and photographs: a visual history of the Army (with photograph exhibition); 5. A lexicon of military terminology.By focussing on the links between Buddhism and the military i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LOGistics INNovation uptake' (LOGINN).

assistant: **Concept**

The LOGINN CSA aims at co-ordinating and supporting RTD projects in the logistics area to improve their capabilities to bridge the gap between pilot implementation and marketable solutions. To achieve this goal LOGINN will set up a collaborative platform (Virtual Arena) to allow the main stakeholders of the logistics domain (industry, SMEs, public authorities, investors and research organizations) to work together on promoting innovative transport logistics solutions aiming at increasing efficiency and with a particular focus on intermodal transport. Over the past decade, several research initiatives have researched and proposed innovative solutions for transport logistics, but the level of adoption in the transport industry has been low, in particular when comparing with other industry sectors. This is due on one side to the transport industry itself, facing issues like a fragmented market structure, price pressure and a high degree of outsourcing, and on the side to the lack of dissemination to relevant stakeholders that has characterized many innovation projects logistics. LOGINN will drive innovation adoption in transport logistics by taking a holistic approach that considers several mutually reinforcing aspects of innovation: business models, logistics practices and technologies. This approach will favour the customisation of RTD results towards industrial demand solutions, supporting the development of sustainable business plans for European RTD projects, exploiting synergies between European RTD projects to enable a seamless exchange between RTD projects and logistics stakeholders and finally enabling and supporting the access to Investors. The main results of LOGINN will be an Innovation Action Plan that will integrate the proposed initiatives for market uptake,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Electrochemical Conversion of Renewable Electricity into Fuels and Chemicals' to be submitted under Horizon 2020.

assistant: **Abstract**

ELCOREL is a consortium combining 5 academic and 2 industrial beneficiaries aimed at training young researchers in the field of the conversion of water and carbon dioxide to fuels and chemicals with the aid of electrocatalysts, of prime importance to the efficient large-scale storage of the excess renewable electricity. The consortium will (i) develop rational catalyst design principles for the electrochemical oxidation of water and the electrochemical reduction of carbon dioxide based on the principles of quantum chemistry and large-scale quantum-chemical calculations, (ii) prepare, synthesize, characterize and test model single-crystalline and nanoparticulate catalysts, and (iii) implement high surface area catalysts in large-scale electrolysers at industrial laboratories. The fellows to be employed in ELCOREL will be part of a unique network of academic and industrial world leaders in their respective expertises, and will receive a dedicated multidisciplinary and intersectoral training through mandatory extensive training and research periods at the non-academic partners. Furthermore, they will go through an extensive training programme balancing scientific, personal andentrepreneurial skills. ELCOREL will generate a new generation of electrochemical researchers ready to deal with the academic and industrial challenges of securing Europe’s future energy independence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Long lifespan battery for hybrid vehicles' (LIFE-BATTERY) targeting Horizon 2020.

assistant: **Abstract**

Batteries are the key element of hybrid vehicles (HEV) and they are responsible for the technical and economic performance of HEVs, the main problem and therefore also the greatest technological challenge.We have already developed LIFE-BATTERY, a new prototype of NiM-H battery able to carry out 2,000 charge/discharge cycles representing an increase of four times in the battery lifespan. As a consequence, the cost per kilometer is six times cheaper compared to current batteries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'COaching and Mentoring of sMEs for Research CommercIALISation and Exploitation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Commercialise project will be to provide knowledge to the European Commission, enabling them to implement an efficient and effective coaching and mentoring scheme to increase the commercialisation of R&D results from the dedicated SME instruments in Horizon 2020. Despite high demand, existing programmes to support SMEs have not delivered the impact on Europe expected. As stated in the 2013 Research for SME Work Programme, “Too many good ideas and research results are not commercially exploited because companies lack the skills, competencies and capabilities to develop and to implement strategic business plans ensuring deployment and commercialisation of innovation.” Growth coaching has been shown across Europe to effectively eliminate the barriers to growing through innovation, and many lessons can be learned and applied to the EC's dedicated SME instrument. Commercialise will take a structured approach to assessing existing coaching and mentoring programmes of relevance, using this knowledge to design best-in-class support, and piloting the support in challenging environments across Europe to ensure the model is robust and ready to be applied. As shown in this proposal, we believe a well-designed coaching and mentoring programme could increase the European GVA generated by the dedicated SME instrument by up to €1.7 billion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DNA-binding domain Conditioned Precision Genome Editing' under Horizon Europe.

assistant: **Concept**

Genome editing in human therapies has the potential to revolutionize modern medicine. With numerous clinical trials underway and the recent approval of the first genome editing therapy, the field is rapidly advancing. However, there is a consensus that clinical genome editing tools must be efficient, precise and safe. Current tools predominantly rely on host cell DNA repair pathways to complete the editing process, which poses a risk for unintended editing events. Host cell DNA repair independent, fully programmable editing tools represent a new class of genome editing technologies, significantly expanding the potential for delivering life-saving therapies to patients. Genome editing tools that fulfil these characteristics are enzymes that recombine DNA. While there has been some success in engineering these enzymes to recognize and act on therapeutically relevant targets, their time-consuming and labour-intensive generation has hindered widespread implementation. DC-PGE aims to address this shortcoming. We have recently demonstrated that recombinase activity can be conditioned by internally fusing a zinc-finger DNA-binding domain into the enzyme's coding sequence, thereby making the enzyme activity contingent on zinc finger DNA binding. This pioneering discovery presents a genuine opportunity to develop next generation and best-in-class genome editing enzymes.DC-PGE aims to i) build a platform to apply DNA-binding conditioned precision genome editing to DNA-recombining enzymes, ii) develop a pan-recombinase system for immediate targeting of virtually any genomic sequence and iii) apply the technology to correct the genetic cause of MECP2 duplication syndrome at nucleotide precision. DC-PGE will serve as a foundation for advancing innovative treatments and improving pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Desert Storms - Towards an Improved Representation of Meteorological Processes in Models of Mineral Dust Emission' (DESERTSTORMS).

assistant: **Innovation**

This project aims at revolutionizing the way the emission of mineral dust from natural soils is treated in numerical models of the Earth system. Dust significantly affects weather and climate through its influences on radiation, cloud microphysics, atmospheric chemistry and the carbon cycle via the fertilization of ecosystems. To date, quantitative estimates of dust emission and deposition are highly uncertain. This is largely due to the strongly nonlinear dependence of emissions on peak winds, which are often underestimated in models and analysis data. The core objective of this project is therefore to explore ways of better representing crucial meteorological processes such as daytime downward mixing of momentum from nocturnal low-level jets, convective cold pools and small-scale dust devils and plumes in models. To achieve this, we shall undertake (A) a detailed analysis of observations including station data, measurements from recent field campaigns, analysis data and novel satellite products, (B) a comprehensive comparison between output from a wide range of global and regional dust models, and (C) extensive sensitivity studies with regional and large-eddy simulation models in realistic and idealized set-ups to explore effects of resolution and model physics. In contrast to previous studies, all evaluations will be made on a process level concentrating on specific meteorological phenomena. Main deliverables are guidelines for optimal model configurations and novel parameterizations that link gridscale quantities with probabilities of winds exceeding a given threshold within the gridbox. The results will substantially advance our quantitative understanding of the global dust cycle and reduce uncertainties in predicting climate, weather and impacts on human health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovation Fostering in Accelerator Science and Technology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Particle accelerators are a key asset of the European Research Area. Their use spans from the large installations devoted to fundamental science to a wealth of facilities providing X-ray or neutron beams to a wide range of scientific disciplines. Beyond scientific laboratories, their use in medicine and industry is rapidly growing.Notwithstanding their high level of maturity, particle accelerators are now facing critical challenges related to the size and performance of the facilities envisaged for the next step of particle physics research, to the increasing demands to accelerators for applied science, and to the specific needs of societal applications.In this crucial moment for accelerator evolution, I.FAST aims at enhancing innovation in and from accelerator-based Research Infrastructures (RI) by developing innovative breakthrough technologies common to multiple accelerator platforms, and by defining strategic roadmaps for future developments. I.FAST will focus the technological R&D on long-term sustainability of accelerator-based research, with the goal of developing more performant and affordable technologies, and of reducing power consumption and impact of accelerator facilities, thus paving the way to a sustainable next-generation of accelerators. By involving industry as a co-innovation partner via the 17 industrial companies in the Consortium, 12 of which SME’s, I.FASTwill generate and maintain an innovation ecosystem around the accelerator-based RIs that will sustain the long-term evolution of accelerator technologies in Europe.To achieve its goals, I.FAST will explore new alternative accelerator concepts and promote advanced prototyping of key technologies. These include, among others, techniques to increase brightness and reduce dimensions of synchrotron lig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular mechanisms underlying control of renal epithelial proliferative homeostasis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This research grant has two major aspects. The first seeks to understand the molecular and cellular basis of the evolution of clear cell renal cell carcinoma(ccRCC), the most frequent form of kidney cancer. We will utilise an integrated approach based on mouse genetics, the use of primary kidney epithelial cell culture systems, genetic screening approaches using RNA interference libraries and analysis of the genetic and molecular changes that arise in human kidney tumours. The rationale behind these studies is that by better understanding the molecular causes of ccRCC it will be possible to identify new molecules or signaling pathways that could serve as appropriate therapeutic targets. The second aspect of this grant relates to the development of a flexible experimental platform that will allow the rapid and simultaneous up- and down-regulation of gene expression in the mouse kidney in a manner in which the affected cells are marked by a luminescent marker. This system will be based on the injection of modified lentiviral gene overexpression and gene knockdown vectors, allowing us to exploit recently-developed genome-wide cDNA libraries and RNA interference libraries. This experimental system should be equally applicable to other organ systems and will allow for the first time a systematic approach to the manipulation of gene expression in living mice, additionally bypassing the time limitations associated with conventional mouse genetic approaches. We aim to develop this system within the biological context of this grant and will combine it with live-animal imaging approaches to generate a series of mouse models of ccRCC. These will ultimately serve as invaluable tools for testing novel therapeutic approaches against this currently untreatable disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Properties of complex electronic materials and biomaterials' under Fifth Framework.

assistant: **Concept**

The aim of this project is to carry out two high level conferences, Transport and Dynamics in Complex Electronic Materials", in Porto, Portugal, 2001, and "Spin and Charge Transport in Nanostructures', in Braga, Portugal, 2003. The purpose is to review some of the major sources of complex electronic behaviour both in conventional bulk systems, in nanostructures, and biological materials. This programme intends to increase awareness of the new problems and challenges brought by increasingly sophisticated experimental methods (improved energy and time resolution, artificial nanostrucuturing, atomic scale microscopy and manipulation) in the perspective of the quantum behaviour of the electronic system, and its manifestations in a variety of materials , including biological systems. The target audience is young researchers (PhDs and post-docs), which we hope to atract to this exciting and timely field.The two events are well related to each other. Topics for first event are heavy fermions and manganites, mesoscopics, disorder and quantum Hall effect, transport and magnetic properties in nanostructures and low dimensional systems. These topics were chosen in view of their importance in the characterization of complex electronic behavior and relevance to the understanding of mesoscopic and nano-structured materials. The second event, more specific, will focus on the excitations in both electronic devices and biomaterials, in particular in DNA, hopefully resulting in insight into their relationship to structure and function.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00178-2.pdf"