RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of electronic and dynamic properties of large van der waals complexes' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The principal objective of the research project is the theoretical evaluation of electronic and dynamic properties of large van der Waals complexes. The coupled cluster approach has proven powerful in describing weakly bounded systems and is actually the only theoretical method that offer and accuracy of 1 cm-1 in e.g. dissociation energies. The treatment of large complexes requires large scale computations, using so-called integral-direct techniques. The first part of the project is devoted to further developing these techniques for treating the singlet and triplet excited states of van der Waals complexes. Ones implemented, the method will be applied to the study of interesting complexes for which accurate experimental data are available, and to predict the properties of others still not studied experimentally. Training content (objective, benefit and expected impact) The main objective is to establish a new research line at U. Santiago by enabling host institution researchers and Ph.D. students to participate in a state of the art research project and gain training through the proposed courses and lectures. Links with industry / industrial relevance (22) The method will be applied to the study of van der Waals molecules that play a key role as models for processes like solvation and adsorption, both essential in many industrial chemical reactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High throughput analytical screening for metal-protein complexes in the biological environment' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The goal of the project is the development of a novel analytical tools allowing in-vivo speciation of metal-protein complexes. The interest in this topic is driven by the fact that this information turns out to be crucial for the understanding of the molecular mechanisms of metal transport, chelation, and biotransformation which govern the bioavailibility of the metal and resistance of an organism to metals present in high concentrations in the environment. There is sufficient evidence in human for the carcinogenicity of cadmium and cadmium compounds; therefore the project is focused on the detection and characterization of proteins that are molecular targets for cadmium in model organisms such as Arabidopsis thaliana.The analytical tools are going to be based on two complementary approaches. In the first one, consisting of in vivo screening for a non-denaturating 2D gel electrophoresis, laser ablation ICP MS detection will be developed. In the alternative approach, a library of proteins of an organism will be created by the conventional (denaturating) 2D electrophoresis and made react with cadmium. For screening the library, electrophoresis on a chip coupled with ICP MS via a dedicated nanonebulizer will be developed for the high-throughput detection of the metal-protein complexes in the biological environment. Structural information of cadmium-protein will be obtain by use of molecular mass spectrometry MALDI-TOF (matrix assisted laser desoption ionisation time-of flight) MS and ES (electrospray) MS/MS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CalScreener® – an innovative device for Bacterial Analysis and Diagnostics through Growth and Energy-release in Real-time'.

assistant: **Concept**

SymCel provides a novel cell-based assay tool for real-time cellular bioenergetics measurements. Our key product, the calScreenerTM, is the first multichannel calorimetric system specifically developed for cell-based assays, which to date has been sold to the pharmaceutical research segment only. Even though calorimetry is a highly advanced research tool, it is considered not suitable for broad scale uptake into daily clinical practice. Through the BADGER project we intend to break this paradigm by validating and commercializing an in vitro diagnostic tool, that is based on isothermal micro calorimetry, for determining MIC for antimicrobial susceptibility testing (AST) of hetero-resistant sepsis causing strains. By providing a tool for the easy, correct and timely diagnoses of hetero-resistant and extensively resistant infections, we will redefine the commercial application segment for calorimetry systems (from pure research settings -> near patient diagnostics) and take AST to a new level of accuracy and speed.The clinical importance of AST is increasing in line with the growing concerns over antimicrobial-resistance (AMR) and the misuse of antibiotics. Lack of a rapid, low-cost and readily available solution contributes to the inappropriate prescribing and overuse of antibiotics. Clinicians are in need of an accurate and rapid diagnostic test to increase antibiotic stewardship, introduce combination treatment for critically ill patients and help combat AMR. The calScreenerTM will meet the users’ needs by providing a reliable diagnostic tool with high speed, specificity, and sensitivity in a smartly designed and packaged device with the tools available to perform testing in a near-patient setting. In all, the Phase 2 project will lay the foundation to clinically valida
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High-temperature Electrochemical Impedance Spectroscopy Transmission electron microscopy on energy materials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The great challenge for humankind is to mitigate climate changes by replacing fossil fuels with renewables. We will have to store excess energy produced by solar and wind power for usage in dark and calm weather. Excess energy can be stored electrochemically by high-temperature electrolysis cells as they have the potential to store vast amounts of electrical energy by conversion to chemical fuels. Solid oxide electrolysis cell (SOEC) technology is well known and proven, but not price competitive with storage of fossil fuels. To drive the SOEC research towards a breakthrough, it is critical to determine relations between electrochemical activity and structure/composition in the cells. Electrochemical impedance spectroscopy (EIS) is a very powerful method for determining the contribution from processes in the cell to the overall activity. EIS cannot show structure/composition which is offered by transmission electron microscopy (TEM). Conventional TEM, however, does not offer insight into active cells, but only post mortem analysis.  High-temperature electrochemical TEM is extremely challenging because this requires a) that hard and brittle ceramic cells are thinned to electron transparency (ca. 100 nm), b) that the cells are carefully designed to allow for characterization of the layer interfaces, and c) that the cells are characterized during exposure of i) reactive gasses, ii) electrical potentials and iii) temperatures up to ca. 800 C.The aim of HEIST is to cover step a) to c), i.e. to transform TEM into an electrochemical lab for high-temperature electrochemical experiments including EIS. HEIST will give us live images of nanostructures and composition during operation of the electrochemical cells and thus disclose structure-activity relations. This is important, bec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Financial Integration and Macroeconomic Stability in Europe' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This project investigates the degree of financial integration among the EU member countries and the effect of this integration on economic growth and macroeconomic stability of Europe. Standard economics textbook treatment of international capital mobility is very clear on three main functions of integrated and efficient capital markets: 1) asset-price arbitrage ensures that people in different countries face same prices for a given asset; 2) people in different countries can share risks to their consumption; 3) new saving regardless of its origin is allocated towards the most productive investment opportunities. Researchers use these conditions to judge whether or not financial markets are integrated leaving the measurement of the extent of integration aside. In addition given the caveat that any of these conditions can break in a world of uncertainty, pooling countries and regions that are at different stages of development will not be appropriate for the purpose of investigating both the degree and the effects of financial integration. Dr. Kalemli-Ozcan developed a methodology with her collaborators to measure the extent of financial integration among regions of federations such as U.S. and Japan, during her last 7 years of research in the U.S. In this project she will focus on Europe. In the light of the institutional and cultural differences between Northern and Southern Europe, knowing the extent of financial integration, reasons behind the differences, and the effects on growth and macroeconomic stability has utmost importance for policy. Both the academicians and the policy makers still do not know how much integration EU has achieved, whether European capital market integration is associated with smaller or larger fluctuations within member countries, and also
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Effective redesign of oxidative enzymes for green chemistry' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Enzymes are extremely powerful natural catalysts able to perform almost any type of chemical reaction while being mild by nature and highly specific. In fact, the delicate functioning of enzymes forms the basis of every living creature. The catalytic potential of enzymes is more and more appreciated by the industry as many industrial processes rely on these sophisticated catalysts. However, the number of reactions catalyzed by enzymes is restricted as enzymes only have evolved to catalyze reactions that are physiologically relevant. Furthermore, enzymes have adapted to the direct (cellular) environment in which they have to function (e.g. operative at ambient temperature, resilient towards proteolysis, catalytic turnover rate should fit with metabolic enzyme partners). This excludes the existence of enzymes that do not fit within boundaries set by nature. It is a great challenge to go beyond these natural boundaries and develop methodologies to design ‘unnatural’ tailor-made enzymes. Ideally it should become possible to (re)design enzymes to convert pre-defined substrates. Such designer enzymes could theoretically exhibit unsurpassed catalytic properties and, obviously, will be of significant interest for industrial biotechnology. The OXYGREEN project aims at the design and construction of novel oxygenating enzymes (designer oxygenases) for the production of compounds that can be used in medicine, food and agriculture and the development of novel powerful and generic enzyme redesign tools for this purpose. The enzymes and whole-cell biocatalysts that will be developed should catalyze the specific incorporation of oxygen to afford synthesis of bioactive compounds in a selective and clean way, with minimal side products and with no use of toxic materials. For this, generi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rational combination therapies for metastatic cancer' (CombaTCancer).

assistant: **Concept**

Targeted therapy (TT) is frequently used to treat metastatic cancer. Although TT can achieve effective tumor control for several months, durable treatment responses are rare, due to emergence of aggressive, drug-resistant clones (RCs) with high metastatic competence. Tumor heterogeneity and plasticity result in multifaceted resistance mechanisms and targeting RCs poses a daunting challenge. To better understand the clinical emergence of RCs, my work focuses on the poorly understood events during TT-induced tumor regression. We recently reported that during this phase drug-responsive cancer cells release a therapy-induced secretome, which remodels the tumor microenvironment (TME) and propagates disease relapse by promoting the survival of drug-sensitive cells and stimulating the outgrowth of RCs. Consequently, intervening with combination therapies during the tumor regression period has the potential to prevent the clinical emergence of RCs in the first place. Here, we outline strategies to (1) understand how RCs emerge and (2) to leverage our findings on the TME remodeling for combination therapies. First, we will develop a novel and innovative parental clone-lookup method, that will allow us to identify and isolate treatment-naïve, parental clones (PCs) that gave rise to RCs. In functional experiments, we will assess (i) whether PCs were already resistant before or developed resistance during TT, (ii) whether PCs have a higher susceptibility to develop resistance than random clones, and (iii) the mechanistic basis for metastatic competence in different clones. Second, we will study the TT-induced TME remodeling, focusing on the effects on tumor vasculature and immune cells. We will utilize our results to target PCs and RCs by combining TT in the phase of tumor regressi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Safety Analysis of SMR with PAssive Mitigation strategies - Severe Accident', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Small Modular Reactors (SMR) are one of the key options for the near-term deployment of new nuclear reactors. Currently in Europe there is a growing interest towards the deployment of SMRs, and several activities are underway in many countries preparing for possible licensing needs. In particular, Integral Pressurized Water Reactor  (iPWR) are ready to be licensed as new builds because they start from the well-proven and established large Light Water Reactor (LWR) technology, incorporate their operational plant experience/feedback, and include moderate evolutionary design modifications to increase the inherent safety of the plant. However, despite the reinforcement of the first three levels of the Defence-in-Depth (DiD), e.g., with the adoption of passive safety systems, a sound demonstration of iPWR ability to address Severe Accidents (SA) should be carried out (DiD levels 4-5). The main objectives of the project will be to transfer and adapt such knowledge and know-how to iPWR, in view of the European SA and Emergency Planning Zone (EPZ) analyses. The main elements considered are: (i) the identification of plausible SA scenarios for iPWRs with the related conditions in the vessel and in the containment, (ii) the study of the applicability of the existing experimental databases to iPWR and identify new experimental needs, (iii) the assessment of the capability of internationally recognized European and Non-European computational tools (largely used in Europe)  to describe the behaviour of the most promising iPWR designs during SA scenarios, and (iv) the prediction of the resulting radiological impact on- and off-site, taking into account special SA mitigation/management strategies. The expected outcomes of the project will help speeding up the licensing of iPWRs in Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetoelectric couplings in solids and related phenomena: First-principles theory' (MAGNETOORBITAL).

assistant: **Concept**

This proposal deals with theoretical and computational studies of megnetoelectric couplings and related phenomena in solds.The first goal is to develop and apply first-principles methods capable to describing the full magnetoelectric response ofantiferromagnetic insulators to static fields.  Previous work has successfully deal with the response associated with the spin of theelectrons, but the orbital contribution to the magnetic interaction was not included. We shall develop a framework where both spin and orbital responses are included.The second goal is to investigate the magnetoelectric coupling at optical frequencies, in an effort to explain the surprisingly large optical response that has been measured in Cr2O3. The methodologies developed for this purpose will also be used to study the natural optical activity (natural circular dichrroism) of trigonal Se and Te, with particular attention to bandstructure effects.The third goal is to develop a computational scheme based on crystalline Wannier functions to calculate accurately the orbital magnetization of metals, both spontaneous (in the case of ferromagnetes), or induced by an external perturbation (in the case ofthe magnetic shielding tensors of nonmagnetic metals).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ice volume changes of Icelandic ice caps in the last 75 years – a view from the air' in the context of a Seventh Framework call.

assistant: **Objectives**

The ICEVOLUME project aims to quantify the ice volume changes of Icelandic ice caps from the 1930s to the present through time series of Digital Elevation Models (DEMs). The DEMs will be produced by stereophotogrammetry on historical oblique and vertical aerial photographs. We already have access to a unique collection of aerial photographs and the new LiDAR DEMs from 2008-2012 that provide us with the necessary raw data for DEM production. Difference DEMs (dDEMs) will be produced in Geographical Information Systems (GIS) and analyzed together with orthophotographs that visually shows the glacier changes. We aim to interpret the causes of the detected ice cap changes by co-analyzing existing meteorological data, glacier surge records, ice-marginal measurements, and other datasets. The proposed project will deliver a 3D view of Icelandic ice cap volume changes through the last c. 75 years. This will significantly advance our current understanding which is mainly based on ice-marginal measurements and point measurements of ablation and accumulation. The value of similar historical aerial photographs for quantifying ice volume changes over the last 80 years has recently been highlighted by the host institution in Nature Geoscience in a study of SE-Greenlandic glaciers. The host institution is the Palaeoenvironment and Climate group at the Centre for GeoGenetics, Natural History Museum of Denmark. The host provides excellent facilities for the proposed photogrammetry and remote sensing work, and has an excellent publication record in this field. The best facilities and expertise required for this project are in place and provide the optimal chance of achieving the goals.