RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NETworking tropical and subtropical Blodiversity research in OuterMost regions and territories of Europe in support of sustainable development' to be submitted under Sixth Framework.

assistant: **Abstract**

NET-BIOME brings together 7 outermost regions and several overseas territories which belong to Europe but are located in tropical and subtropical areas. They are characterised by 3 main features: (a) their terrestrial and marine biodiversity is exceptional (b) their environments are most exposed to the climate change impact, natural hazards and pressures of human activities (c) biodiversity is a fundamental asset for their economic development.Today, the local authorities fund and/or manage research activities in this thematic area. They develop original strategies and models which could be shared by as well as transposed to continental Europe: adaptation to climatic change and anthropic pressures, conservation and management of biodiversity in an integrated and sustainable manner. However, for several reasons (distances, isolation, deficiency of resources and critical mass, access to facilities and information), both cooperation and coordination of research activities are poorly done, between the regions themselves and between them and continental EU. Therefore, there is a lack of trans-regional funding and integration of research on biodiversity. Local authorities have decided to prepare a regional ERA-NET in order to initiate and stimulate co-operation and co-ordination of research programmes for the sustainable and integrated management of biodiversity in a step-by-step approach: 1- Collect, exchange and provide access to information on research programmes, actors and results by building an interactive information system; 2. Design a joint strategy profile including the analysis of barriers to cooperation and of common strategic issues and good practices; 3. Develop joint activities such as clustering of regionally funded research projects, mutual access to faciliti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A safe and effective non-surgical and reversible procedure for weight loss' (GDS), addressing dissemination and exploitation.

assistant: **Impact**

With nearly 15% of the current population over 18 years old obese, obesity is on the verge of becoming a global pandemic. Obesity can lead to serious health issues, like diabetes, coronary heart diseases and several types of cancers. Each year obesity related conditions cost globally over €1.7 trillion and cause almost 2.8 million deaths a year. It is estimated that the EU spends almost 7% of their GDP in obesity treatments. Current gold standard for weight loss is effective, but extremely expensive and has life-threating side-effects. The GDS is an innovative non-surgical procedure for weight loss, that is reversible, it is 7 times cheaper than the golden standard (RYGB) and almost 4 times cheaper than alternative procedures, and can be done in 30 minutes without hospitalization time or the need of big surgical team.  The GDS is composed of a polymeric flexible sleeve inserted in the duodenum with a patented anchoring system to stop the sleeve from migrating to the small intestine. The sleeve prevents weight gain through malabsorption of calories and the anchor increases the satiety sensation in the user. Allevetix has already performed successful pre-clinical trials on animals.Within the overall innovation project Allevetix requires to miniaturize the GDS; conduct a First in Human safety clinical trial, and safety and efficacy Pivotal Clinical trial; setup a production line with an external CMO; obtain the CE mark; and prepare a sound commercialization and got-to-market strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'LIVING WITH ART. Domestic decorative sculpture in Western Roman Empire: reconstructing display, sociocultural dynamics, and addressing productive and economic processes' (LIVART), addressing dissemination and exploitation.

assistant: **Impact**

LIVART is a multidisciplinary, innovative project that will investigate decorative sculptures in domestic contexts during the Roman period. They offer insights into sociocultural practices of private Roman spaces, revealing aspects of daily life not recorded in written sources and reflecting personal preferences of their owners and inhabitants. The project examines function, aesthetic significance, and societal, economic, and cultural roles of these sculptures within Roman families. It aims to understand how they reflect and influence domestic practices, social relationships, gender and diversity roles, and economic dynamics in the Roman Empire. The research integrates archaeology, art history, archaeometry, and 3D/VR technologies to achieve its objectives. Geographically, it focuses on the Western Roman provinces, within a chronological framework extending from the Republican era to the end of the Empire. The project, developed at the Rheinische Friedrich-Wilhelms-Universität Bonn (Germany), is planned to last 24 months and includes an eight-month secondment phase in three renowned laboratories: Laboratory for Analysing Materials of Ancient origin (LAMA) at the Università Iuav di Venezia (Italy), the Stable Isotope Laboratory at the Institute of Environmental Geology and Geoengineering (IGAG) of the National Research Council in Rome, and the Department of Geology at the Autonomous University of Barcelona (UAB). These secondments ensure the proper integration of various hard science methods and techniques for stone analysis, which are crucial to the project’s research objectives, particularly those productive and economic dynamics derived from the identification of raw materials used to carve the sculptures. Therefore, LIVART addresses significant knowledge gaps and emp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enabling Technologies and Drug Discovery: Continuous Flow Processes to Discover Novel Antiviral Inhibitors'.

assistant: **Objectives**

VIRO-FLOW project aims to integrate the advantages of continuous flow chemistry with in vitro microfluidic bioassay technologies for the fast and efficient discovery of novel and innovative inhibitors of the Hepatitis B Virus (HBV). This programme aims to contribute to the development of innovative methodologies that allow more efficient production of new compounds with anti-viral activity, specifically against HBV, for future transfer of technology and knowledge between different sectors with relevant economic impact.  The global objective of this ITN-EID programme is to provide an innovative and high-level training in drug discovery and enabling technologies for 3 Early-Stage Researchers (ESRs), supported by a network of experts in anti-infective therapeutics, specifically virology and bacteriology in AiCuris, a pharmaceutical company; and the Institute of Chemical Research of Catalonia (ICIQ), a research Institute focused on sustainable chemistry in the field of catalysis and flow chemistry (through its technology development unit ERTFLOW). This ITN will educate the next generation of well-prepared ESRs, providing them with the skills necessary to pursue successful careers in a rapidly emerging field that requires novel multidisciplinary technological development as well as it will also be the channel for educating well-trained researchers with the scientific, technical and entrepreneurial skills so highly needed in the drug discovery field.This goal will be achieved through industrial doctoral training that includes international, interdisciplinary and inter-sectorial mobility, and that integrates both academic and industrial contributions. The research programme is composed of three closely related projects in the research areas of medicinal chemistry (including or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The International Dimension of Environmental Policy', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

In doing so the second meeting builds on the first, because government policy making can only be analysed with a deep understanding of firms' behaviour. For example, if firms' investment is discouraged by environmental policy, governments may have an incentive to weaken their environmental policy in order to reduce capital flight or to stimulate foreign firms to locate within their borders (ecological dumping). In this case there may be gains from environmental policy co-ordination. The meeting will explore those issues, and examine government policy making under different political constitutions. Furthermore, both meetings will assess under which circumstances social welfare increases and equity and sustainable growth are enhanced.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00146-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A multicenter randomised trial of directly observed treatment for tuberculosis patients in sub-saharan africa'.

assistant: **Innovation**

The proposal is a multicenter randomised trial with 2 nested studies.(1) The aim of the randomised trial is to compare the effect of directly observed treatment (DOT) and self supervised treatment (SST) on cure rates in pulmonary TB patients in the context of a flexible and patient-centred approach to care. A total of 1412 TB patients will be randomly assigned to one of 2 arms. In the intervention arm, a DOT strategy will be carried out.(2) A patient patient-centred approach will be implemented in both arms and evaluated in terms of processes.(3) Focus groups discussions and interviews with patients & caregivers will be conducted to explore perceptions of DOT & SST and barriers to treatment adherence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Managing Risk and Costs in Open Source Software Adoption' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MOTIVATION: By 2013 an estimated 85% of all commercial software packages will include OSS<br/>PROBLEM: Failure rates in OSS projects are reported to be higher than 50%. In 2011, inadequate risk management was identified among the top 5 mistakes to avoid when implementing OSS-based solutions. Understanding, managing and mitigating OSS adoption risks is therefore crucial to avoid potentially significant adverse impact on the business, in terms of time to market, customer satisfaction, revenue and brand image<br/>APPROACH: The RISCOSS project will offer novel risk identification, management and mitigation tools and methods for community-based and industry-supported OSS development, composition and life cycle management to individually, collectively and/or collaboratively manage OSS adoption risks. Using advanced software engineering techniques, RISCOSS will deliver a risk-aware technical decision-making management platform integrated in a business-oriented decision-making framework, which together support placing technical OSS adoption decisions into organizational, business strategy as well as the broader OSS community context<br/>OBJECTIVES: To offer:- OSS risk management techniques and practices. Scalable, flexible and efficient quantitative and qualitative decision-making techniques- Business models for OSS solutions. Flexible, customizable business models for OSS adoption considering involved stakeholders, their strategies and decision-making- Strategic modelling and analysis of OSS ecosystems. Modelling approach to map out relevant organizational and OSS community context- Tool Support. Rich, usable, collaborative and customisable web-based software platform offering integrated risk-management techniques developed in this, and reused from other, projects<br/>KEY RESU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Excellence Hub for Advancing Innovation in Gene Therapy'.

assistant: **Objectives**

GeneH proposes to create an excellence hub in gene therapy through strategic partnerships within and beyond Widening countries. Despite gene therapy's recognized priority in genomic medicine and its potential for high-curative economic impact, challenges persist in its development process, from conceptualization to commercialization. GeneH intends to address these challenges by serving as a catalyst for overcoming barriers and expediting research translation.To achieve this, GeneH will establish a robust and sustainable hub that builds upon already established ecosystems in the field and recent H2020 WIDENING projects to implement centers of excellence in gene therapy (GeneT in PT and CTGCT in SL). The academic partners at its core, namely, the University of Coimbra (UC) in Portugal and the National Institute of Chemistry (KI/NIC) in Slovenia , have reached substantial achievements by partnering with industry (Bluepharma,  Biocant Park, Biosistemika, Jafral), hospitals (CHUC EPE), policy makers (CCDRC, RRA LUR), ecosystem/innovation supporters (SIH EEIG, IPN), and patient associations (APAHE, ZOPS). Partners in the two ecosystems share a common goal: treating life-threatening or chronically debilitating diseases considered incurable. By harnessing the combined expertise and resources of its partners, GeneH aims to drive cross-sectoral collaboration through its 4-helix network, in a multidimensional approach that will gather further investment, address ethical and regulatory aspects, implement de-risking approaches, educational and training programes, joint R&I programs, and prepare the path for clinical trials of new gene therapy products, while actively engaging society.By positioning itself as a leading hub in gene therapy, in line with regional, national, and Europea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration' in the context of a Horizon 2020 call.

assistant: **Objectives**

Transplantation of autologous split-thickness skin -the epidermis with a tiny layer of dermis- remains the golden standard for various skin wounds like burns and large trauma. This treatment, however, comes with a number of serious drawbacks, including pain, mobility-limiting contractures and disfiguring scars. The SkinTERM consortium will address wound healing in a completely different way, recapitulating (certain aspects of) skin embryonic development in adults, and aiming for regeneration rather than repair. Skin organogenesis will be induced by key elements taken from the extracellular matrix of foetal and non-scarring species and by employing (stem) cells from relevant cellular origins. The starting point for the study is the remarkable capability of early foetal skin and skin from the spiny mouse (Acomys) to heal perfectly without scars/ contraction and with appendices such as hair follicles. Novel biomaterials and skin substitutes will be developed and evaluated. In order to effectively embrace this new approach, the PhD students need to have knowledge in key elements of basic science, regenerative medicine and biomaterial sciences. As translation to medical devices and especially advanced therapy medicinal products is currently too limited, we will give the PhD students a solid theoretical and practical foundation on topics like regulatory affairs, GMP and GCP, as well as secondments in industry. Driven by both the enthusiasm to gain basic scientific insights and the need for efficacious and innovative therapies, the students will acquire expertise through cutting edge scientific projects and will be trained by leading experts in all required skills to further develop their scientific findings into real life-science products. The SkinTERM program will thus creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exploring glycosidic neo-epitopes of degenerative hippocampal granules in aged mice and humans: implications for ageing and dementia', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Ageing is the main correlate of dementia and several other neurodegenerative diseases which currently affect more than 6 million people in Europe. Molecular understanding of these brain conditions is important for their prevention and treatment. In mice, pathological granular structures positive for periodic acid-Schiff stain have been found in the hippocampus with increasing age. The degenerative process of granule formation appears to originate in astrocytes, but adjacent neuronal structures are affected and, accordingly, associated memory impairments have been described. Recent studies reported that granules express glycosidic neo-epitopes, a hallmark of the degenerative granule formation process. This neo-epitope has additionally been found in Lafora bodies of a mouse model of Lafora disease, a fatal neurodegenerative condition. On the other hand, mice serum contains natural IgM antibodies that recognise the glycosidic neo-epitope, suggesting a potentional removal mechanism. In this project, I aim to describe the structure of the glycosidic neo-epitopes of the hippocampal granules as well as the composition of the degenerative granules and Lafora bodies. To achieve these goals, I will employ a multidisciplinary approach exploiting glycomics and neurobiology, with the application of leading-edge technologies that include histological methods, analytical techniques, MALDI-MS imaging and laser-capture microdissection. Moreover, the binding patterns of the anti-neo-epitope natural IgMs will also be explored. Finally and importantly, the expression of the glycosidic neo-epitope in human brain will be assessed. Overall, the knowledge generated will provide new data on brain degenerative processes underlying age-related memory impairments in humans. Ultimately this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Programming for Future 3D Architectures with Many Cores'.

assistant: **Concept**

The shift from systems-on-chip (SoC) to manycore architectures brings new hardware and software challenges ranging from seamless integration of processors, memories the design of modular systems and application software to run on massively parallel and scalable platforms. Manycores will benefit tremendously from 3-dimensional (3D) integration technology that enables distribution in space of computational and storage functions to achieve unprecedented performance levels.PROD3D is an ambitious high risk and high reward project that builds upon existing European world-class R&D expertise of the partners. PRO3D will innovate in both hardware and software technologies and demonstrate the effectiveness of manycores by an integrated and concerted effort in key aspects of hardware and software design. The uniqueness of this proposal stems from the experience of the partners in various aspects of manycore design that need to be addressed concurrently.The key outcome of PRO3D will be a holistic system design methodology to bring a drastic improvement of productivity to reduce cost development and time to market for future embedded computing. In particular, PROD3D will: i) develop a system software flow that can operate transparently on parallel manycore platforms; ii) develop formal methods for software design guaranteeing the composability and correct operation of both Hardware and software; iii) explore the impact of 3D integration for new computing architectures iv) Extend the software-flow to 3D-stacked manycores.The PRO3D consortium brings together world-class leaders in their own field with competencies to cover software, architecture and 3D integration. One of the key differentiators of the PRO3D consortium is its access to an industrial many core System on Chip, named Pla