RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Security of Aircraft in the Future European Environment (SAFEE)'.

assistant: **Objectives**

SAFEE is a large integrated project designed to restore full confidence in the air transport industry. The overall vision for SAFEE is the construction of an advanced aircraft security system designed to operate during on-board terrorist threat scenarios. The main goal of this system is to insure a full secure flight from departure to arrival destination whatever the identified threats. The project's baseline is the assumption that upstream identification control and airport specific security measures have all been completed. The project is focussed on the implementation of a wide spectrum of threat sensing systems, and the corresponding response actions against physical person(s) or electronic intruders. One of the key aspects of the project is an integrated information management system underpinned by a secure communication system. For reaching these objectives SAFEE has 5 key activities named subprojects (SP):* SP1: Onboard threat detection: a large spectrum of various threats detection system is proposed* SP2: Threat Assessment and Response Management System: a urgency decision making tool* SP3: Flight reconfiguration includes an Emergency Avoidance System and an automatic guidance system to control the aircraft for a safe return* SP4: Data protection system securing all the data exchanges (in and out the aircraft)* SP5: Innovation activities, dissemination, economics, exploitation, legal and regulatory issues about citizen's privacy and rights. The proponents are major European industrial actors of the Aeronautical sector associated with a high level research centre, several relevant Smes and specialised universities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Combining electrophysiology and cognitive computational modeling in research on meaning in language' in the context of a Horizon 2020 call.

assistant: **Objectives**

Language and meaning processing have been investigated with event-related brain potentials (ERPs), providing direct time-resolved measures of electrical brain activity, and with connectionist network models, providing mechanistic implementations of the assumed processes. However, there has been very little contact between these fields, even though a combination of both methods could be highly beneficial. Based on initial evidence from the applicant, the present project therefore aims to integrate ERPs and computational models in research on language and meaning.Specifically, the N400 ERP component is widely used in research on language and meaning. As the computational mechanisms underlying this component are still unclear, we recently related the N400 to a model of word meaning and observed a close correspondence between N400 amplitudes and semantic network error. As network error is often conceptualized as implicit prediction error, we took these results to indicate that N400 amplitudes may reflect implicit prediction error in the semantic system. However, because the most typical N400 effects are observed during sentence processing, I propose to extend connectionist N400 simulations to sentence processing (Objective 1). Furthermore, the development of syntactic and semantic knowledge in the model should be related to the development of syntactic and semantic ERP components, both in developmental time and when processing words in sentences over time (Objective 2). Next, we aim to test behavioral predictions derived from this model-based account of N400 amplitudes, namely that larger N400 amplitudes should enhance implicit memory formation (Objective 3). Finally, the model-based account of N400 amplitudes as reflecting implicit prediction error should be tested in a co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular dissection of viral genomes for future antiviral treatments' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Viruses are obligate pathogens with massive impact on global health. Nearly all currently marketed antiviral drugs target viral enzymes. We hypothesize that hitherto unrecognized virus-encoded transmembrane proteins may prove valuable as pharmaceutical targets.Through a systematic dissection of viral genomes (WP1) we will identify potential transmembrane segments in a defined workflow. We will predict their function in silico (WP2) as being either (A) internalizing transmembrane proteins or (B) ion channels. Segments showing promising transmembrane and/or internalization motifs will be expressed, functionally characterized and evaluated in proof-of-modality assays (WP3). The newly identified internalizing proteins may transfer a molecular Trojan horse, a toxin payload, into infected cells, which will be tested with a generic fusion-toxin protein (Mode A), while the potential viral ion channels (viroporins) will be tested for their ability to mediate a current via formation of ion pores (Mode B). In WP4, the internalizing transmembrane proteins passing the WP1-3 attrition will be utilized for initial drug discovery and fusion-toxin protein design. Through co-internalization with the viral transmembrane protein, the toxins may prevent long-term pathologies by eradicating the virus. The novel viroporins will be screened for inhibition using ion channel drugs regulatory approved for other purposes. This ensures fast access to the market through drug repurposing, allowing for prevention and treatment of acute virus pathology.This project on new ground entails high risk, yet also creates opportunities of enormous gain, considering the huge unmet medical needs for effective and specific antiviral therapeutics. However, the biggest gain is the potential for ground-breaking disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular mechanism for long-term maintenance of synaptic plasticity changes' (2002-2006).

assistant: **Innovation**

Dynamic changes in synaptic strength are now thought to be the cellular mechanisms responsible for information storage in the nervous system. The formation of long-term memory and the expression of long term synaptic plasticity require the activation of gene transcription and protein synthesis de novo. In this context the CREB family of transcription factors appears to be one of the core components in the molecular switch that converts short- to long-term memory.The aim of this project is to study the role of the CREB family of transcription factors in the acquisition and consolidation of memories. We will use different lines of transgenic mice related with the CREB transcription factors such as VP16-CREB (a constitutively active CREB variant), A-CREB (a dominant negative CREB mutant), VP16-SRF (a constitutively active SRF variant) and CBP (CREB co-activator) to study memory formation and consolidation. As a member of a multidisciplinary group I will carry out electrophysiological studies to characterized synaptic plasticity phenomena in the hippocampus and amygdala, two structures that are related with spatial and fear conditioned memories respectively.These data together with behavioural experiments will allow us to understand the molecular processes of learning and memory. The results of this project may help to find treatments for the increasing number of neuro-degenerative diseases in the European countries as a consequence of the ageing population.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mitochondrial unfolded protein response and the role in ageing' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cells use sensor pathways compartmentalized in subcellular organelles to recognize stress conditions, including aberrant protein folding, and in response activate gene expression programs aimed at maintaining cell survival and restoring homeostasis. Fine-tuning of the protein-folding environment in organelles like mitochondria is important for adaptive homeostasis and may participate in development of human diseases and ageing. Work in cultured mammalian cells and more recently in Caenorhabditis elegans has highlighted the importance of mechanisms linking perturbations in the protein-folding environment in the mitochondrial matrix to the expression of nuclear genes encoding mitochondrial proteins. This mitochondrial stress pathway is named mitochondrial unfolded protein response. Much of our knowledge regarding the organelle unfolded protein response (UPR) signalling comes from studies of the endoplasmatic reticulum stress response machinery. In contrast, a potential role of mitochondria in UPR pathway is far less defined, and physiologic regulators of this pathway have not been defined.Here I propose three complementary strategies to identify molecular mechanisms and signalling pathways of the mitochondrial unfolded protein response (UPRmt) under different stress conditions and during ageing. My laboratory has experience in using transgenic mice and C. elegans as experimental tools and both of these powerful model systems will be used in this project.Specific aims of this proposal are:Aim 1. To identify specific substrates of UPRmtAim 2. To define mechanisms regulating mammalian UPRmtAim 3. To elucidate the role of UPRmt signalling in ageing""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Instructing Immune System to Regenerate Musculoskeletal Tissues via Structurally Programmable Bio-Inks'.

assistant: **Concept**

The musculoskeletal tissue is the framework of our lives. It holds, shapes and supports freedom of movement of our body and protects the crucial internal organs (brain, heart and lungs). It is responsible for our body’s immunity by providing source of stem cells (bone marrow) that readily transform to immune system cells fighting pathogens, so any damage it poses significant threat to the individual’s quality of life. The patient’s immune system does not only play crucial role in fighting various pathogens but is also vital in inducing normal healing of damaged tissues. Patients, especially with prolonged diseases, ranging from diabetes to HIV tend to have decreasing capacity for healing after injuries due to their compromised immune system. In this project we aim to develop 3D-printed materials instructing the immune systems via the immune cell-material interactions through controlled mechanical properties and biochemical cues organised in 3D manner (i.e. biofabrication using additive manufacturing techniques) for treatment of musculoskeletal defects in patients with immune-system imbalance. Chemical approaches combining synthetic self-assembling peptides and hyaluronic acid together with 2D nanomaterials will be explored for fabrication of such well-defined printable scaffolds with high shape fidelity and gradient-like architecture. In a second step, we hypothesise that reprogramming of patient’s own immune cells (ex-vivo) using the developed printed materials and a microfluidic approach can be achieved through the stimulation of patient’s immune cells interacting with the designed material surfaces to produce the exosomes and signalling molecules (cytokines). Successfully harvested biomolecules would hold potential for personalized therapies in immune-deficient patie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Screening and identification methods for official control of banned use of antibiotics and growth promoters in feedingstuffs' under Fifth Framework.

assistant: **Concept**

In order to protect human health, the authorisation of several antibiotics (avoparcine, bacitracin-zinc, spiramycin, tylosin and virginiamycin) and growth promoters (carbadox and olaquindox) as feed additives has been withdrawn. Available methods of analysis are not suited for control of illegal use. The main objective is to develop and validate adequate multi-methods for the detection of the banned substances at sub-additive levels in feed.The following techniques will be studied: microbiol inhibition, high voltage electrophoresis, TLC, HPLC and LC-MS. The output will be a control strategy consisting of fully validated screening and confirmatory multi-methods. The second objective is to create a bank of reference standards of the banned substances with guaranteed stability for 10 years. Sufficient amounts will be stored to provide the official control laboratories in the EU member states with the material for at least 10 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HYGIENIC SLUDGE MANAGEMENT FOR AGRICULTURAL UTILISATION' (SMAG).

assistant: **Innovation**

Recent and expected developments in sewage treatment all over Europe have had profound effects on sludge production. Changes in environmental legislation coupled with difficulties in establishing and maintaining sustainable sludge management methods, make sludge disposal a complex problem. This puts authorities involved in wastewater treatment under pressure, which may lead to the adoption of environmentally inappropriate practices. It is well recognised that current sludge disposal practices in Southern Europe (where landfill and/or uncontrolled agricultural use dominates) are not sustainable in the medium and/or long term and other alternatives must be investigated.The aim of this technology transfer project was to demonstrate in three pilot sites in Southern Europe, two in Greece, (Lamia and Rethimnon) and one in Spain or Portugal, that sludge management options where domestic sewage sludge treatment with the addition of quicklime (CaO) in ratios that provide pH values over 12 for over 3 months, can create the background for agricultural valorisation.The pilot locations were typical Southern Europe medium size towns with tourist activities in balance with agricultural activities. It was anticipated that other communities in Europe, facing similar problems with sludge disposal could benefit by the experience gained and the innovative approach.The short-term objectives included:- high quality sludge products prior to agricultural land application, in terms of odours and nutrient content.- sludge product management without health risks from pathogens (during storage, spreading).- toxic compound monitoring on sludge and agricultural soil.- financial benefits from technology application and sludge product marketing.With regards to the longer term objectives, the project a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Psychosocial Factors and Cardiovascular Disease in Spain' (2007-2013).

assistant: **Innovation**

The study of the possible associations of psychosocial factors as job strain, depression, social support and stress, with the development, treatment and prognosis of cardiovascular disease (CVD) is a promising research field. Job strain and depression are highly prevalent conditions, and CVD remains to be the first cause of death in most countries around the world. Nevertheless, only a few cardiovascular studies have been able to study this topic in a low cardiovascular risk country as Spain.We will be able to study the role of psychosocial factors with CVD outcomes within two large cardiovascular cohort studies of workers. The different populations of these studies in terms of geographical location, sex distribution, age range, and different occupations, offer a great opportunity for the study of well defined psychosocial factors and their role in CVD etiology, and progression.We will use well established and already validated questionnaires to measure job strain, depression, social support and stress.The knowledge produced on the possible associations between common psychosocial factors as job strain and depression with the development and progression of CVD will offer excellent opportunities for preventive cardiovascular interventions not only in Spain but in other countries of the European Union with similar cardiovascular risk.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Robotics for Infrastructure Inspection and MAintenance'.

assistant: **Innovation**

Inspection and Maintenance (I&M) represents a huge economic activity (450 Bn€ market) spanning across sectors such as energy, transport, civil engineering. EU hosts over 50% of I&M robotics offer but there is a bottleneck connecting it to the market and high potential applications. RIMA is a 4-year project aiming to establish a network of 13 Digital Innovation Hubs (DIH) on robotics sharing best practices and providing services to facilitate uptake of I&M technologies.Our challenge is to reinforce this connection and to provide education and training on robotics I&M and to connect the value chain - research, technology companies, service providers, end users and investors- for accelerating economic growth in the field:- RIMA is building upon the network pioneered by SPRINT Robotics extending it to all relevant sectors across the value chain.- The RIMA network encompasses:    o leading research organizations supporting one DIH per region aligned with regional policies and industry sectors.    o Sectorial associations who will make a bridge with end users and industries.- RIMA will offer services including support to testing and technology transfer, coaching and training on robotics for I&M, process optimization and communication. 50.5% of RIMA’s budget will be distributed to SMEs to run experiments using FSTP- RIMA will advise on funding opportunities relying on the S3 Thematic Platform on robotics for I&M federating the common ambition of 13 EU regions.- Network sustainability will be ensured by adapting the SPRINT business modelExpected results are (i) increased competitiveness of EU I&M Robotics, (ii) economic added value by increased productivity and availability of the critical infrastructure (iii) social and environmental impact through improved safety and less emi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Frobenius related invariants and singularities'.

assistant: **Innovation**

This is a project in commutative algebra of positive characteristic, which has also many connections with algebraic geometry.The main goal of this project is to study the relations between some classes of rings that arise in prime characteristic, F-singularities, and three specific notions. These are the symmetric signature, a new invariant defined by the Experienced Researcher in his Ph.D. thesis; the generalized Hilbert-Kunz function, a recent generalization of the classical Hilbert-Kunz function studied intensively in prime characteristic algebra; and the FFRT property, a positive characteristic version of the notion of finite representation type, important in representation theory. As a guideline for the future research, eight concrete problems are stated and will be investigated by the Experienced Researcher with the help of the Supervisor. The strategy to complete this task include the acquisition of new knowledge, which will be obtained, among other things, also through the organization of weekly seminars with the collaboration of the host institution. The arguments of this project, F-singularities in particular, are important topics in commutative algebra and algebraic geometry which are developing and growing fast in these years, especially in the USA and in Japan. As a further way to promote the development of these topics also in Europe, the Experienced Researcher and the Supervisor plan to organize a small workshop which will take place in the host institution at the end of the fellowship.


**Keywords:** Prime characteristic methods,  Frobenius homomorphism,  Hilbert-Kunz function,  Singularity,  Finite representation type