RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The Genetic Basis and Adaptive Significance of Natural Ionomic Variation'.

assistant: **Objectives**

Evolutionary forces are known to drive the fixation of locally adaptive genetic variation within populations, and plants provide an excellent model for investigations into its genetic origins, maintenance and adaptive significance. We aim to take advantage of the natural genetic variation that occurs between populations of the genetic model plant Arabidopsis thaliana to identify gene functions that vary between these natural populations. Such a set of polymorphic genes and gene functions will provide the essential tools required to uncover the genetic mechanisms that drive the fixation of locally adaptive genetic variation within a population. To link natural genetic variation to function, we have applied high-throughput Inductively Coupled Plasma – Mass Spectroscopy (ICP-MS) based elemental-profiling, in combination with genome-wide association mapping and traditional linkage mapping to reveal loci that drive natural variation in the plant's elemental-profile or “ionome” including P, Ca, K, Mg (macronutrients); Cu, Fe, Zn, Mn, Co, Ni, Se, Mo, I (micronutrients of significance to plant and human health); Na, As, and Cd (minerals causing agricultural or environmental problems). Using a combination of laboratory and field-based experiments we propose to uncover the adaptive benefit and evolutionary significance of these naturally occurring polymorphic ionomic loci, along with their molecular function, and underlying causal genetic and epigenetic basis. This information will help determine the evolutionary processes involved in adaptation of organisms to local environments. Such insights will help in predicting the extent and limits of possible future adaptations of plants to changes in the surface chemistry of the Earth driven by a changing global climate, and will have a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Increasingly Anthropogenic Landscapes and the Evolution of Plant-Food Production: Human - Environment Interactions during the Final Pleistocene and Early Holocene in the Levant.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

H-E Interactions will investigate how increasingly anthropogenic wetland landscapes and the reliable resources therein influenced the evolution of plant-food production and the origins of agriculture through the Final Pleistocene into the Early Holocene (ca.23-8 ka cal. BP). It will consider how earlier human-environment interactions shaped this key transition, integrating the latest theoretical Human Niche Construction (HNC) perspectives with environmental archaeology to investigate 5 well-excavated wetland oriented archaeological sites in the S. Levant. It will employ an interdisciplinary, combination of microbotanical approaches, (phytolith, starch and microcharcoal analyses) and geoarchaeology, in particular micromorphology, to investigate the on- and off-site contexts of a temporally broad set of sites to provide long-term, direct evidence of ancient plant-use. To achieve this, training in geoarchaeology, GIS and multivariate statistical skills will facilitate the production, management and interpretation of the large environmental dataset. As well as providing direct evidence of plant-use and environment from a critical H-E threshold, H-E Interactions is the first study in the region to directly examine how HNC practices impacted the origins of agriculture. So far, the origin of agriculture has been largely understood as a consequence of human reactions to environmental push & pull factors. This project presents an alternative approach and takes the view that increased use of ‘low-ranked’ resources may reflect deliberate human modification, management and/or food processing innovation, increasing the relative abundance and ease of acquisition of ‘low-ranked’ resources, resulting in ‘upward mobility’ of that resource. HNC provides a new way to consider changing pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Uncovering the basis of behavioral individuality across developmental time-scales' (BehavIndividuality).

assistant: **Innovation**

A fundamental question in biology is why different individuals show different behaviors. While individuality in behavior is usually explained by genetic heterogeneity or differences in environmental exposures, more recent studies have shown that stable behavioral variation is also observed among isogenic individuals that were raised in the same environment. However, this important and potentially conserved epigenetic source of individual-to-individual behavioral variation remains largely unexplored. I have recently developed a novel imaging setup, using C. elegans, that allowed for the first time to study behavioral individuality across the full development time of animals, at high spatiotemporal resolution and under tightly controlled environmental conditions (Stern et al. Cell 2017). By using this unique system I found that isogenic animals show long-term behavioral individuality that persists across all developmental stages, and was dependent on specific neuromodulators. In this proposal I suggest to study how behavioral individuality emerges across development from non-genetic differences among individuals. In particular, I plan to (i) identify neuronal circuits and variations therein that lead to different behavioral states among individuals by combining my established methods for longitudinal behavioral quantifications with cutting-edge neuronal imaging and molecular techniques; (ii) study the role of conserved epigenetic mechanisms in generating stable neuronal and behavioral variations by integrating high-throughput gene-expression, neuronal, and behavioral analyses in single animals; and (iii) explore how stressful conditions affect behavioral individuality. I hypothesize that stress may enhance variation as a population-level mechanism to diversify risk in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Plasmid Evolutionary Innovation and Adaptation to Defense Systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Plasmids are self-copying genetic elements that can move between bacterial species. They frequently carry antimicrobial resistance (AMR) genes, making understanding the factors that affect their spread through bacterial communities an urgent challenge. Exploiting bacteria’s natural defence systems to block plasmid spread is an exciting possibility. Recent years have seen a huge increase in the known number of ‘anti-phage’ systems that stop bacterial viruses (phage) from gaining a foothold in the cell. Some of these systems also defend against incoming plasmids, but the pace of discovery has outstripped the ability to experimentally test all relationships. We need computational approaches: by developing new methods, PLEIADES will bridge the gap and give us new insights into plasmid evolution.The central hypothesis of PLEIADES is that selective pressure from ‘anti-phage’ defence systems also shapes the genomic architecture of plasmids. To better understand plasmid evolution we need to explore how variation in plasmid content and structure is linked to defence systems. We will tackle three objectives. First, we will build statistical models that relate the diversity of defence systems and plasmids across bacteria, controlling for other factors to deliver a systematic understanding of their relationship. Second, we will investigate the modular evolution of plasmids, which evolve by frequent rearrangements, using new computational frameworks that capture this plasticity together with tools to predict functions for plasmid proteins (the majority of which are currently unknown). Third, we will explore the role of defence systems in plasmid competition, investigating diverse plasmids from metagenomes to build a data-driven theory of their coevolutionary dynamics. By combining c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MOTEG-Reimagining Mobility with worldwide highly innovative auxiliary components for commercial vehicles' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

As a result of the global megatrend of e-mobility, there is a demand for highly efficient auxiliary units for braking and steering systems, as well as for example tipping devices of an excavator and the lifting platform of a truck for electric buses and commercial vehicles. Currently, this is causing massive disruption to automotive supply chains, while innovative solutions are lacking. State-of-the-art auxiliary power units were developed for fossil fuel engines and do not meet the requirements of the new mobility, especially in terms of operating performance, noise level and total cost of ownership. MOTEG has introduced an optimized set of innovative and unique auxiliary aggregates for electric buses and commercial vehicles. The development path for the aviation industry has enabled us to identify market opportunities in the automotive sector and to find synergies in an application-oriented product series development of electrical auxiliary units for commercial vehicles, the compAux series. This approach has enabled us to set new standards in technology and efficiency.Ouz aggregates occupy a third of the volume, half the weight and are with 68dBa noise level much quieter than all existing fossil-fuel powered competition products. The leading factor is the reduced energy consumption by a factor of 2 compared to the competition. MOTEG enables manufactures to produce electric vehicles with 10% longer range or 10% less investment in battery and reduced Total Cost of Ownership (TCO) by about 20 T€. Nevertheless, the price level of the MOTEG products is below the price of existing competition products. At the same time, we will expand our solutions to develop products for many other types of commercial vehicles, including construction machinery and agricultural vehicles. Us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ancient genomic reconstruction of convergent evolution to agriculture' in the context of a Horizon 2020 call.

assistant: **Objectives**

As global climates warmed ca. 10,000 years ago came a remarkable convergent transformation of human lifestyles that occurred independently in multiple continents and human populations. This transition from hunter-gatherer subsistence to food-production catalysed large-scale population growth, offering the opportunity for increased rates of adaptation, but also rapidly presented a large number of independent human populations with a new evolutionary challenge. This project will use ancient population genomics—the only way to directly reconstruct human genetic evolution—to study whether evolutionary processes during the agricultural transition differed in differed regions. Which genomic adaptations were associated with the agricultural transition? Did adaptation to hunter-gatherer and agricultural lifestyles act on similar genetic architecture in different instances? To which extent did adaptation in domestic dogs—the only species domesticated prior to the agricultural transition—occur in convergence with humans? To answer these questions, the project will generate ancient genomic data from pre-agricultural and early agricultural populations from multiple human- and domestic dog populations from Africa, Central America, and Southeast Asia. This will be achieved with direct sequencing as well as a new human ~850,000 SNP capture panel designed to avoid bias towards Eurasian ancestry. We will also develop new computational methods robust to the challenges posed by ancient genomes to identify adaptive admixture, analyse copy number variation, test continuous population models, and statistically assess convergence in the genomic architecture of adaptation. Leveraging cutting-edge ancient genomics and two model organisms for the genomic basis of phenotypic variation, this proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Risk of injury to footwear manufacturing operatives' to be submitted under Fourth Framework.

assistant: **Abstract**

Current methods of footwear manufacturing rely on a combination of operative's skill and machine assistance. Many operations are short cycle and repetitive, they have the potential to cause long term injury due to their repetitive nature. This project proposes to carry out a review of the most widely performed operations to establish their degree of risk to the operative's health. An inevitable secondary result will be to identify the potential for improvements in overall efficiency by applying ergonomic principles. The benefits of a successful conclusion will be universally applicable, not only to the Prime Proposer but to all footwear manufacturers, machinery suppliers and training organisations. It is envisaged that these benefits will include. - Guidelines on working practices. - Improved machine design and workplace layout. - Recommended training procedures. - Improved operative/machine utilisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Signaling Cascades in Metabolic Diseases' (SiCMetabol).

assistant: **Concept**

Over 380 million people suffer from diabetes worldwide, with majority of cases being attributed to type 2 diabetes (T2D). Obesity is a major risk factor predisposing to the development of this disease. T2D is characterized by peripheral insulin resistance in combination with relative insulin deficiency that results in hyperglycemia and hyperlipidemia. Liver and adipose tissue are central for regulation of glucose and lipids levels. However, during T2D the hepatic glucose uptake is reduced while rates of gluconeogenesis and lipogenesis are increased. In the adipose tissue, T2D leads to decreased glucose uptake, perturbations in secretion of adipokines and increased lipolysis. Importantly, dysfunction of the liver and the adipose tissue during T2D is caused by defective phosphorylation signaling cascades and normalization of these pathways was shown to attenuate the course of T2D. However, the specific roles of different classes of signaling molecules in these organs remain poorly characterized. We hypothesize that the cross-talk of different classes of signaling molecules determines regulation of metabolism.Thus, we aim to identify the signaling networks regulating metabolism. The results generated in my own laboratory suggest that the Pkd family kinases are the crucial regulators of metabolic homeostasis. Specifically, Pkd1 and Pkd2 promote obesity and diabetes while Pkd3 controls liver function. Thus, we plan to characterize the molecular mechanisms controlling Pkds signaling. In parallel, we will utilize screening approaches to identify novel, non-canonical signaling modules (phosphatases and components of the ubiquitin system) regulating abundance, localization and phosphorylation of targets of Pkds and, in the long term, also other kinases implicated in T2D.By ident
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Inspiring New doctorate Candidates to Empower the Production of interconverTIble and Optimized ziNc-based batteries and supercapacitors'.

assistant: **Innovation**

To respond to the incredibly challenging development of efficient manufacturing and recycling methods of energy storage devices and the significant shortage of young generation talents in this field, INCEPTION - Doctoral Network is proposed. It will provide an excellent triple-I (Interdisciplinary/Intersectoral/International) research and training network, which aims to face Zinc-based energy storage development (i) by exploring the innovative idea of supporting the development of rechargeable batteries (RB) and supercapacitors (SC) by early addressing recyling&manufacturing within Safe and Sustainable by Design framework (ii) by exploiting excellent expertise and advanced technologies at leading universities, research centers, enterprises, and associations across EU, UK, India, and Brazil. This will maximize their ability to convert new knowledge/ideas into products and services for the industrial, social, and economic benefit, and thereafter becoming the future leaders in academia, industry, and the public sector, which is crucial for the EU.With its triple-I-dimension spans 7 major scientific disciplines (electrochemistry, physics, materials engineering, chemistry, electronics, computational science, economics). The resulting highly integrated, international, intersectoral, interdisciplinary collaboration will enable the delivery of 15 Ph.D. degrees (13 beneficiaries). All Ph. D fellowships are devoted to singular and intercrossed (high interconnection between candidates) aspects that are crucial to meet the energy storage challenges of EU, recognized by the HEU, the Batt4EUPartnership, and UN Sustainable Development Goals. The strong interaction across the scientific themes is crucial for: (a) the training-through-research, (b) the knowledge sharing, (c) the develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Surface for Urban Innovation: The Politics of Designing Poverty in Colombia and Czechia' (SURBANIN), addressing dissemination and exploitation.

assistant: **Impact**

The SURBANIN project explores the global operation of social innovations that tackle urban poverty through architecture, art or design (AAD). Various schools, collectives and studios use AAD to help poor communities of the global South through innovating their material environment, but this trend is visible in the global North, too. Social innovations thus have played an increasingly important role alongside more established global and national social policies. However, regardless of their positive or negative impacts, they are very often locally decontextualised and isolated from the urban and cultural politics that make poverty. As a result, such innovations may not eliminate poverty, but rather redesign it. The project will compare “slums” in Colombia and homelessness in Czechia to establish a novel understanding of how innovations globally emerge and travel, how they are locally implemented and with what impact. Rather than fully embracing or rejecting AAD innovations, the project inquires why they are adopted and whether the context of adoption determines their outcomes. The research for this project, having been undertaken first by the Graduate School of Design at Harvard University and then by the Georg-Simmel Center for Metropolitan Studies at Humboldt University in Berlin, will focus on a number of heterogeneous social innovations: from cable cars and macro-murals in cities of Colombia to small-scale architectonic improvements and design innovations in homeless encampments in cities of Czechia. Combining cultural anthropology and its study of everyday life with the urban-sociological and urban-geographical emphasis on urban political economy, and with urban planning’s interest in the development and design of urban environment, the project addresses a number of