RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targets and biomarkers for antiepileptogenesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Epilepsy is a devastating condition affecting over 50 million people worldwide. This multidisciplinary project is focused on the process leading to epilepsy, epileptogenesis, in adults. Our main hypothesis is that there are combinations of various causes, acting in parallel and/or in succession, that lead to epileptogenesis and development of seizures. Our central premise and vision is that a combinatorial approach is necessary to identify appropriate biomarkers and develop effective antiepileptogenic therapeutics. The project will focus on identifying novel biomarkers and their combinations for epileptogenesis after potentially epileptogenic brain insults in clinically relevant animal models, such as traumatic brain injury (TBI) and status epilepticus (SE); explore multiple basic mechanisms of epileptogenesis and their mutual interactions related to cell degeneration, circuit reorganization, inflammatory processes, free radical formation, altered neurogenesis, BBB dysfunction, genetic and epigenetic alterations; and translating these findings towards the clinic by validating biomarkers identified from animal models in human post TBI brain tissue and blood samples, post-mortem brain tissue in individuals that died soon after  SE, and human brain and blood samples from chronic epilepsy cases. The project will identify novel combinatorial biomarkers and novel disease-modifying combinatorial treatment strategies for epileptogenesis, create an Epilepsy Preclinical Biobank, and validate translational potential of results from animal models in human tissue. To adequately address the proposed goals, the project will develop technological breakthroughs, such as completely novel chemogenetic approaches, novel MRI techniques, novel multimodal organic recording devices for simulta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RD-CONNECT: An integrated platform connecting registries, biobanks and clinical bioinformatics for rare disease research' under Seventh Framework.

assistant: **Concept**

Despite examples of excellent practice, rare disease (RD) research is still mainly fragmented by data and disease types. Individual efforts have little interoperability and almost no systematic connection between detailed clinical and genetic information, biomaterial availability or research/trial datasets. By developing robust mechanisms and standards for linking and exploiting these data, RD-Connect will develop a critical mass for harmonisation and provide a strong impetus for a global “trial-ready” infrastructure ready to support the IRDiRC goals for diagnostics and therapies for RD in close collaboration with the successful A/B projects. It will build on and transform the current state-of-the-art across databases, registries, biobanks, bioinformatics, and ethical considerations to develop a quality-assured and comprehensive integrated hub/platform in which complete clinical profiles are combined with -omics data and sample availability for RD research. The integrated, user-friendly RD-Connect platform, built on efficient informatics concepts already implemented in international research infrastructures for large-scale data management, will provide access to federated databases/registries, biobank catalogues, harmonised -omics profiles, and cutting-edge bioinformatics tools for data analysis. All patient data types will be linked via the generation of a unique identifier (“RD-ID”) developed jointly with the US NIH. The RD-Connect platform will be one of the primary enablers of progress in IRDiRC-funded research and will facilitate gene discovery, diagnosis and therapy development. RD-Connect has the RD field at its heart and brings together partners with a strong track record in RD research (gene discovery and development of innovative treatments), as well as commit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Financing retirement in europe: public sector reform and financial market development'.

assistant: **Concept**

The nature of pensions requires that the young researchers gain direct access to market and government professionals working in the area. This Network will secure this through seminars, conferences, designated focus groups and internships. The Network will develop close links with policy-makers and regulators, fund sponsors, consulting actuaries, auditing accountants and fund managers. In this way, a bridge in training will be built between pure research and practice.In addition, the Network will ensure the young researchers:- are assigned a mentor to guide them both through their studies and in developing their outside contacts- participate and present papers at the meetings of the network- undertake visits and secondments to other nodes of the network to benefit from the teaching programmes available in those institutions, including seminars- participate in the planned 5-day summer school- participate in relevant CEPR and other nodes' research workshops - attend focus groups organized at CORE and LSE that bring together policy-makers, pension-fund professionals and other stakeholders to discuss industry developments and policy formation etc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways' to be submitted under Horizon 2020.

assistant: **Abstract**

The key challenge in regenerative medicine is to re-establish a physiological tissue organization as this is conditional for proper tissue functionality. In the cardiovascular field, tissue engineering of blood vessels and heart valves requires the development of a tri-laminar structure. Previous attempts to establish this organization have been mainly trial-and-error based. Therefore, to force breakthroughs and accelerate clinical translation, computational modeling is critical to understand and predict the process of neo-tissue regeneration starting from non-living biodegradable materials (i.e. scaffolds).The main drivers of regeneration are (1) hemodynamic loads that trigger mechanically-driven tissue growth and remodeling, and (2) signaling interactions between cells that control the emergence of global tissue organization (e.g. layering of vessels and valves). While the first aspect currently receives vast attention, the modeling of cell signaling in the context of tissue engineering remains an unexplored area. In this project, I aim to obtain a mechanistic understanding of how a critical pathway in the cardiovascular system, i.e. the Notch signaling pathway, drives the emergence of global tissue organization while interacting with mechanical cues. I will adopt a unique, multi-disciplinary approach, where quantitative in vitro experiments will be performed to inform novel multi-scale computational models of Notch signaling and its consequences on regeneration. I will leverage these models to understand and predict in vivo regeneration of engineered cardiovascular tissues starting from various initial conditions.If successful, this project will have a tremendous impact on the development of rational guidelines for ensuring functional tissue regeneration, which repre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Incremental Nonlinear flight Control supplemented with Envelope ProtecTION techniques' (INCEPTION), addressing dissemination and exploitation.

assistant: **Impact**

Recent developments in the areas of nonlinear control theory and sensor technology paved the way to the derivation of flight control laws that are significantly less dependent on nominal aircraft model data. In addition, novel and complex methods which make use of advanced fault detection and online identification algorithms to estimate the aircraft’s achievable flight envelope and to provide protection in case of adverse conditions, such as system failures or damages are arising.Project INCEPTION proposes to develop and combine the abovementioned research topics, exploring the INCEPTION of an innovative approach to the design of automatic flight control systems, supported by sensor-based (almost model-independent) control laws with the ability of online reconfiguration following failure scenarios.By employing self-reconfigurable mechanisms and control laws that are less sensitive to model mismatch INCEPTION aims to provide an enhanced level of safety for future aircraft. The objective is to predict and adapt to safe flight regimes of operation, even in the presence of unprecedented and unknown failures, and to enable the development of generic flight control systems, applicable to different aerial platforms. These motivations are completely aligned with the European vision for aviation safety portrayed in the ACARE Flightpath 2050 Report, which envisages the prediction and mitigation of technical and operational issues through advanced on-board systems.Project INCEPTION focuses on researching and developing the best approach to achieve the proposed targets, to implement it into a coherent system and to test its performance in Unmanned Aircraft and evaluate its future applicability to General and Commercial Aviation. To accomplish these tasks, the INCEPTION Consortium i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pathogenesis of pulmonary disease' (PULMO-NET) under Sixth Framework.

assistant: **Objectives**

Exposure of the lung surface to air-born pollutants or other toxic/ infectious agents causes reactions at the air-liquid interface, the immune system, the epithelial barrier and adjacent tissue. This may result in acute and/or chronic diseases, representin g an increasing socio-economic burden to the European Community. Their underlying pathogenetic mechanisms involve physico-chemical events, such as air-liquid interface phenomena, and cellular events, such as immune defense, secretion, transport and barrier (dys)functions. The further elucidation of the pathogenesis of pulmonary disease will be achieved only if an integrated research approach is undertaken. This will need to encompass biophysical, biochemical, (patho)physiological and immunological events ta king place in a narrow space. The proposed RTN is headed by top scientists in these diverse but complementary fields of basic pulmonary biology and offers excellent training opportunities. It will provide a structured training program for early-stage and e xperienced researchers and increase the number of broadly trained expert pulmonary scientists exposed to different ¿schools of thought¿ and needed for new developments in pulmonology. Extensive transfer of knowledge will enhance methodological progress and exchange of research tools/ideas needed to develop miniaturized organ systems for in vitro pulmonary toxicity testing, and to define endpoint parameters for lung damage. This will provide a basis for new therapeutic approaches, the identification of risk factors, the prevention of disease and a diminished need for animal experiments. The participation of a SME and the strong connections between the university partners and pharmaceutical and other companies will provide training in intellectual property and entr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular mechanisms of GPCR heteromers signaling' (SignalHet) targeting Horizon Europe.

assistant: **Abstract**

G Protein Coupled Receptors (GPCRs) are key mediators of how cells sense and react to their outside environment. Traditionally, these receptors have been thought to function as individual units at the cell surface. Over the past decade, new evidence has shown they can assemble in larger complexes to form new signaling entities and vastly expand a cells capacity to respond to its environment. Thanks to their strong tissue-specificity, these complexes -termed heteromer- also form important targets for the development of new drugs with less side effects. Still, our understanding of the molecular mechanisms by which assembly of GPCRs in complexes transform their signaling properties remain extremely sparse. My proposal investigates how heteromers interact and integrate changes in their environments to generate unique cellular responses. I focus my research on the mGlu2-5HT2A heteromer, as its existence has been demonstrated in humans and is involved in schizophrenia, a debilitating condition that urgently requires new treatments. This proposal is organised in three objectives:1/ A too often over-looked component of a GPCR environment is the lipidic membrane it is inserted in. Using a multi-scale biophysics approach, I will characterise the essential role lipids play in the assembly and function of heteromers, but also how receptors themselves change the membrane they are inserted in to transmit information.2/ I will use cryo-electron microscopy to solve the first structure of a heteromer, bound to its signaling partners, G proteins. I will go even further and develop cutting-edge EM tools to resolve a high-resolution movie of a GPCR heteromer signaling cascade, from receptor assembly to G protein activation.3/ Finally, using single particle cryoEM and fluorescence, I will i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The development of a World Integrated assessment Model of Technology-Economy-Climate change for the investigation of the impact of induced technical and behavioural change on the environment' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This proposed research will look at the current theoretical and empirical works in the area of induced technical change (ITC) and examine the impact of ITC on economic growth, international trade, resource depletion, and climate change. The type of ITC considered will relate to the issues of fuel efficiency, fuel substitution, and emission abatement activities in the context of climate change.The different forms of ITCs will interact or compete for the same investment resources in the economy, and therefore, their total net impact on the economy and the environment may be ambiguous. This needs to be studied. In addition to the induced technical change, which affects the technological parameters of the emissions equation, such as the fuel intensity or emissions intensity per unit of fuel input or activity output, the proposed research will also look at the effects of behavioural or lifestyle changes on the composition and scale of socio-economic activities and therefore of total emissions. This is in addition to the changes caused by the ITC, i.e. the technique effects.The proposed research will look at all these effects and their interactions within the framework of a general equilibrium model of the economy, and link the model to a climate change model. The general equilibrium economic model will be able to handle the issues of the relationship between economic growth, trade, and environmental impacts such as emissions and climate change. The role of induced technical and behavioural change in such a model will be highlighted to give concrete assistance to the design of optimal climate change policy especially within the context of European economies and the Kyoto Protocol.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Milk Powder for Enhancing Probiotic PERformance' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Food technologists from private companies as well as university researchers are currently investing time and effort in the quest of healthier food systems. One innovative solution may be to provide structured dairy powders allowing stabilization and enhancing the performance of bioactive compounds (flavonoid, vitamins, enzymes…) and cells (bacteria). The present project is focused on probiotics stabilization and particularly on Lactobacillus rhamnosus GG. The design of milk powders in Nancy has already proven to be a valuable vector for enhancing the nutritional profile as demonstrated by preservation and controlled release of probiotics during food processing, shelf-life and gastric transit. Nevertheless, the way the bacteria interact with milk components has never been elucidated in order to improve encapsulation yield or survival rate. In addition, the powder form allows a longer shelf-life of the product before incorporation in food systems. Concurrently with this challenge, the number of researchers acting in powder technology and more particularly dairy powders is very limited and only few universities and research centers (mainly located in Europe and Australia) are specialised in this field. In contradiction with this lack of research institutions involved in dairy powder research, 80% of all dairy products may exist in a dry form at some point in their processing lifetime. The project is thus focused on the development of model powders interconnecting process parameters, LGG location in the powder structure (from atomic-, to micro- and macro-scale) and their functionality. This implies an in-depth study of interactions between milk components and LGG, based on the development of new methodologies to characterize the bacterial location within the structure. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HEalth Risk from Environmental Pollution Levels in Urban Systems' to be submitted under Seventh Framework.

assistant: **Abstract**

HEREPLUS will: 1) involve coordination among epidemiologists, biostatisticians, environmental scientists, GIS specialists in order to realize the full potential of GIS technology in environmental health research; 2) develop risk maps relating to human health, and O3 and PM concentrations using the ArcGis approach, taking into account existing and validated epidemiological models, for selection of important and problematic large European urban areas such as Rome, Madrid, Dresden, Athens; 3) improve the knowledge of the potential role of different urban vegetation types for mitigating the O3 and PM pollution levels, and provide best practices regarding the selection of no-VOCs emitting species and management of large green areas located in different neighbouring urban areas; 4) furnish guidelines for municipal managers and administrators deputed to establish urban-environmental measures which combine risk maps, urban vegetation as a sink for ozone and PM, and minimization of sanitary costs, all based on results and knowledge achieved by the project activities as a whole. These guidelines will take the form of best practices recommendations and designs for municipal laws that may be used as a base-line for municipal administrations; 5) disseminate guidelines and best practice indications at a European level, through international workshops and a conclusive report. Specific cardio-respiratory disease, such as asthma, bronchitis, COPD exacerbation, ischemic heart disease, and the morbidity and mortality for these diseases, associated to O3 and PM, will be considered in HEREPLUS.  HEREPLUS will produce the above mentioned risk maps starting from pre-existent environmental and health data, by development of new epidemiological and statistical approach, also in support for the