RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantum Algorithmics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

We will study the algorithmic aspects of quantum information. Our goal is to find new algorithms for quantum computers and new quantum communication protocols that are more efficient than the classical protocols. We will pursue this goal in a number of different ways.<br/>Firstly, we will study concrete problems that may have fast quantum algorithms and develop methods for constructing quantum algorithms. We will investigate the use of quantum walks (quantum counterparts of random walks) and learning graphs (a very new method which appeared less than a year ago) to construct quantum algorithms. We will also study two promising application areas for new quantum algorithms: hidden shift problems and property testing.<br/>Secondly, we will investigate general properties of quantum algorithms, such as the role of various resources (e.g., quantum entanglement or quantum discord) in quantum algorithms. We will study restricted forms of quantum computation, to find the minimum conditions under which universal quantum computation is possible. We will investigate the role of structure in input data in quantum speedups, by studying the maximum quantum speedups achievable in various settings.<br/>Thirdly, we will study the counterparts of those questions in the communication setting. We will work on designing quantum protocols that solve communication tasks more efficiently than any classical protocol and investigate quantum communication in a game-theoretic setting where parties act to maximize their self-interest.<br/>Lastly, we will investigate applications of quantum information concepts in other areas, namely to solve classical problems in computer science and to understand the computational complexity of problems in quantum physics. One of the major applications of a future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sustainable and Cost Efficient High Performance Composite Structures demanding Temperature and Fire Resistance' in the context of a Horizon 2020 call.

assistant: **Objectives**

In order to maintain the leadership of the European aeronautics, the SuCoHS project will investigate potential weight and cost savings in expanding the use of composite materials in areas of demanding high thermal conditions (high temperature and fire). In particular, this project envisages new structural concepts with novel multi-material composites to provide high resistivity against thermal, mechanical and fire loading. These developments also cater for high production rates, providing a cost competitive manufacturing process at minimum material and energy consumption, while reducing the requirement for visual inspection or rework. New solutions for structural health monitoring are considered within the structures to enable condition-based maintenance taking into account actual loading and structural conditions.Instead of an isolated investigation of innovative technologies the project will develop an integrated framework for the adaption of these promising technologies to different aeronautic components to increase efficiency during design, manufacturing and operation. Three industrial use cases are defined from real industrial design challenges to set requirements, to validate new technologies and to demonstrate technical feasibility near to operation environment: a high temperature resistance nacelle component, a composite aircraft interior shell and a tail cone panel substructure.The SuCoHS project gathers 14 partners from 7 European countries, amongst which 2 technical universities, 3 research centers, 4 SMEs and 8 large companies. The requested EU funding amounts to 6 638 944 Euros for a 3-year project duration.


**Keywords:** High-Temperature and Fire Resistant Composite Structure, Multiphysical and Multidisciplinary Analysis, Structural Health Monitoring, Ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Exploiting Transcriptional Adaptation to Develop New Genetic Compensation-based Therapies'.

assistant: **Concept**

Organisms display various mechanisms to compensate for the deleterious effects of harmful mutations.  One such mechanism is transcriptional adaptation (TA), a recently identified mode of gene regulation whereby mutant mRNA decay triggers the transcriptional modulation of so-called adapting genes, independently of protein loss (Rossi et al., Nature 2015; El-Brolosy et al., Nature 2019).  In some cases, TA can lead to functional compensation by upregulating genes that are functionally redundant with the mutated gene.  In our funded project, Transcriptional Adaptation and Genetic Compensation (TAaGC), we are investigating the mechanisms underlying TA and its relevance to human health and disease.  We have now observed TA in human cells and found that splice-switching antisense oligonucleotides (ASOs) can be used as tools to induce TA (Falcucci et al., Nature 2025).  By causing the skipping of out-of-frame exons, these ASOs disrupt the reading frame, thereby triggering mutant mRNA decay and the upregulation of functional paralogs.  Using this approach, we have induced the upregulation of functional paralogs for both the DMD and LMNA genes, mutations in which cause Duchenne muscular dystrophy and laminopathies, respectively.  ASOs have been approved by regulatory agencies, including the FDA, for the treatment of multiple diseases, altogether suggesting that splice-switching ASOs constitute a viable therapeutic approach to induce functional compensation via TA.  In this PoC project, we first aim to further optimize the sequence of TA-inducing ASOs for DMD and LMNA in human and mouse cells in culture.  The optimized human ASOs will then be fully investigated in relevant human cells in regards to their effect on the transcriptome and proteome; the optimized mouse ASOs will be t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Multimodal preclinical imaging probes to evaluate the safety and efficacy of regenerative medicine therapies'.

assistant: **Innovation**

Our inability to accurately monitor the biodistribution of transplanted cells is a major barrier to assessing the safety and efficacy of cell-based regenerative medicine therapies. To assess safety, it is important to know if cells have engrafted into non-target organs so that possible adverse effects can be monitored over time; and to assess efficacy, it is crucial to know what proportion of cells reach the target organ, for how long they persist, and whether they ameliorate injury. Various imaging technologies, including magnetic resonance imaging (MRI), bioluminescence imaging and photoacoustic imaging can be used for monitoring cellular biodistribution and assessing the effect of the cells on host organs and tissues, but no single technique provides high sensitivity, spatial and temporal resolution, and functional and anatomical imaging. It is therefore necessary to combine several imaging approaches. The University of Liverpool is leading the UK Regenerative Medicine Platform Safety and Efficacy Hub. The hub includes all members of the supervisory team. The University has just inaugurated its new centre for preclinical imaging which brings together in a single place a unique suite of state of the art imaging modalities (including high field MRI and photoacoustic imaging). Building on her wide experience in the synthesis, functionalization and assembly of nano/micro-particles gained during her PhD with Irshad Hussain (Pakistan) and a Humboldt Fellowship with Wolfgang Parak (Germany), Sumaira Ashraf (the applicant) will prepare probes tailored for cell labelling and multimodal imaging. She will evaluate and optimize the properties of the probes following cell uptake (live cell imaging, magnetophoresis, etc) and finally test the most promising multimodal probes in mou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'TTR-associated amyloidosis, mechanism for amyloid formation and development of therapeutic strategies' under Fourth Framework.

assistant: **Concept**

Objectives: The purpose of this proposal is to create an animal model in mice for TTR-associated amyloidosis leading to FAP with the long-term goal to generalise the model for other amyloid disease.Brief description: Amyloidoses are diseases of protein conformation. 16 amyloidogenic proteins are known of which the a-amyloid precursor peptide in Alzheimer's disease and the plasma protein transthyretin (TTR) in different forms of familial amyloidosis are best known. Both are associated with neurodegenerative lesions for which there is no cure. They both affect quality of life of individuals and causes large costs for the health care system. TTR is associated with two types of amyloidosis occurring in different time periods of life. The senile form (Senile systemic amyloidosis, SSA) affects 25% of all individuals over the age of 80 years and has mainly manifestations in the heart. It is not a genetic disease, and it is thought that amyloid results from an inherent propensity of TTR to form amyloid with time. The genetic form is dominant autosomal and occurs earlier in life. More that 50 mutations of TTR are known and are associated with familial amyloidosis either with polyneuropathy (FAP) or cardiomyopathy (FZC), diseases with extracellular amyloid fibrils composed of TTR. The most frequent mutation is an exchange of valine for methionine in amino acid position 30 (TTR Met30). The specific objectives are: 1. study mechanisms for amyloid formation as result of point mutations of the TTR gene;  2. to study mechanisms for amyloid formation well as its consequences by developing a transgenic mouse model with overexpressed and mutated TTR genes and by studies of effects on cultured cells;  3. to develop diagnostic and therapeutical reagents.  The project involves creation of h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'GROWING ENERGY EFFICIENCY THROUGH NATIONAL ROUNDTABLES ADDRESSES' (GREENROAD), addressing dissemination and exploitation.

assistant: **Impact**

The project aims at facilitating the dialogue between Italian public and private key actors on financing issues related to energy efficiency in the existing and new buildings sector and fostering collaboration, innovation and action through the establishment of a permanent national roundtable and connected events at local level. The project will set up a national roundtable with selected high level stakeholders in order to allow an in-depth discussion about current barriers and market failures, as well as share best practice and innovative financing solutions, with the goal to improve stakeholders’ awareness and knowledge and to identify the necessary political and regulatory framework. In parallel, local events and initiatives will be organized to engage as many stakeholders as possible, enabling capacity building, dissemination, replication activities and scale up of “success stories”: local actors are one of the main drivers of the energy transition and they bring forward tremendous opportunities for investment and innovation in a number of fields.  National roundtables and local events will be organised in order to trigger a continuous and mutually reinforcing virtuous circle. The combination of a top-down and bottom-up approach will create the conditions for the development of tailor made support tools and instruments for the different stakeholders involved. The outcomes of the national roundtables and the local events will be analysed, and a roadmap for PAs and industry sector including strategic and operative recommendations for the implementation of financial instruments will be elaborated. Connections with past and current similar initiatives at EU level will be pursued throughout the project, in order to keep the national outputs in line with EU requirements a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Direct Imaging of Budding and Fusion of Lipid Droplets Mediated by Proteins in Emulsion Droplets Based on Microfluidics - Dynamics of Proteins Interactions, Assembly and Metabolism Energy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Lipid droplets (LDs) were believed many years ago to be mere passive reservoirs of lipids, which role was limited to supply lipids to cell membranes when needed and to avoid the accumulation of fat in adipocytes leading obesity. Since this last decade a newly focus on LDs has led to understand their dynamic organelles behavior and their implication in many diseases proliferation in cells. Indeed, the virus or proteins linked to them are located on LDs and therefore the understanding of the biogenesis of lipid droplets (by budding from a membrane) and their pathway (fusion between LDs) became of great interest. Unfortunately, a little is understood about that but many Biology labs start now to converge on the topic. However, all the approaches proposed to study the budding and fusion of LDs are done in in vivo systems mostly by knocking down or over expressing a list of proteins, presumable responsible of the effect, and watch the consequences. We think it doesn’t guarantee their direct implication and there is additionally a lack of a clear visualization of the processes and their energy characterization. We propose to use emulsion droplets based on microfluidics so study them. COPI (GTP, Arf1 and coatomers proteins) which is involved in the budding of vesicles is likely implicated in the budding of LDs. To prove that, we will form water drops in an oil containing phospholipids that will cover their interface. The water drops will contain the COPI; oil droplets will be therefore budded from the phospholipid monolayer at the interface: we have preliminary results confirming that. Regarding the fusion process, the way SNARE proteins assembly (v and t-SNAREs) leads to fuse vesicles is believed to provoke the merge of LDs. We will investigate that by forming in microfluidic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microbiota of Andean Food: tradition for healthy products' in the context of a Seventh Framework call.

assistant: **Objectives**

Synergies between European countries and Andean regions will deal for the revalorization of indigenous resources represented by Andean traditional foods. The aim of this project will be the construction of a network based on complementary competences between partners; fruitful exchange between researchers will be aimed by a common scientific project that will be the opportunity to an effective integration of involved groups. Countries from the Andean region are home to a wide range of natural resources, representing an important proportion of the Earth’s total biodiversity. Fluctuating altitude and topography produces countless micro-climatic variations these accounting for a high agricultural diversification. The achievement of multiple agronomic, ecological, economic, culinary and socio-cultural objectives constitutes a main concept in traditional Andean life. The great variety of food available in the Andes does not only provide nourishment, but also good health. In particular the project will focus on the rescue of ancestral Andean foods crops and cattle such as traditional fermented potatoes (Tocosh) and corn (Chicha de Jora) from Perú; fermented beverage Atole agrio “Xocoatolli” from Mexico; fermented milk products (suero costeño and queso Paipa) from Colombia and llama meat and quinoa-based fermented products from North-western Argentina. Scientific experience of the involved groups will be applied as a multidisciplinary approach, using advanced molecular techniques to identify the indigenous microbiota, capitalizing the technological and functional properties of the isolated strains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Co-creating multi-scalar generative change towards sustainable food systems:  learning with sustainable food “communities of practice” in Zimbabwe and the UK' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This Fellowship aims to enhance and expand the career potential of the applicant over the course of 36 months of finely-tuned support and advanced skills training from the University of Sheffield, under the guidance of Professor Peter Jackson. The goal is to enable the researcher to move into a phase of professional stability and academic independence, to become fully established as leading researcher and innovator in the inter-disciplinary field of agri-food studies, as well as maturing, in the longer-term, to become an international thought-leader within Human Geography and Feminist Political Ecology. This Fellowship will position the researcher competitively in terms of securing a permanent faculty position at a leading University within the next four years, as well as supporting her to secure longer-term research funding within the next 3-7 years. Based at The Institute for Sustainable Food, the researcher will build upon previous project experiences in the Caribbean, the UK, Zimbabwe and Tanzania, to consolidate her skills and international expertise as a social scientist across the interconnected domains of agri-food systems, diverse economies, sustainability and local innovation processes. Key questions that guide this proposal are: How does transformation towards more sustainable food systems take place, across different scales from the individual, to the community, to the regional, to the international? What are the socio-ecological, economic, political and institutional factors that enable the co-creation of change towards more sustainable food systems? How can researchers and policy-makers support the co-creation of change processes, across different scales, to allow more sustainable food systems to emerge? In asking these questions, this research and career
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Kinetics in Soft Molecular Layers- from interstellar ices to polymorph control'.

assistant: **Objectives**

This project centers around the investigation of molecular mobility in solid layers by a truly multidisciplinaryapproach: combining the expertise from crystal growth, astrophysics, and chemistry. We aim toanswer long standing questions in the context of two cross-disciplinary applications: the formation andevolution of interstellar ices and the solid state transition from one crystal structure — polymorph —to another. The first is important for fundamental questions dealing with the origin of life, specificallyconcerning the delivery of molecules—like H2O, CO2 and organic molecules—to habitable planets.The second application is of great interest to the pharmaceutical industry where polymorph control iscrucial. The polymorphic form controls the solubility of the compound and is therefore key in dosedetermination.The goal of the investigation is to obtain an understanding of mobility in molecular layers on themolecular level in order to (i) understand the processes in interstellar ices leading to the meeting of tworeactive species, (ii) identify the trapping mechanisms in interstellar ices, (iii) predict which molecules can survive in ices in the harsh environment of star and planet forming regions, (iv) determine which processes are fundamental to polymorphic conversion, and (v) design a way to inhibit or promote polymorphic conversion. I propose to study the mobility in molecular layers This project centers around the investigation of molecular mobility in solid layers by a truly multidisciplinary approach: combining the expertise from crystal growth, astrophysics, and chemistry. We aim to answer long standing questions in the context of two cross-disciplinary applications: the formation and evolution of interstellar ices and the solid state transition from one crystal