RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Adsorbed Layers of Natural Organic Macromolecules on Solid Substrates: Structure, Interactions, and Mechanisms of Growth' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Surface adsorption of organic substances in aqueous solutions is a ubiquitous mechanism that affects many environmental processes, such as fate and transport of contaminants. In engineered systems, adsorption of organic molecules causes fouling and prompts biofilm formation. Fouling is a major impediment to the successful development of membrane technology to increase the supply of safe water. Control of surface adsorption in aquatic systems requires fundamental knowledge of the physicochemical interactions at water-solid interfaces. The objective of this study is to understand the mechanism of adsorption of humic substances and polysaccharides onto surfaces with well-defined surface composition. In particular, the substrate chemistry will be tailored to represent environmentally relevant surfaces. Surface adsorption/desorption will be investigated either by optical reflectometry or surface plasmon resonance under varying physicochemical conditions. The layer structure, hydration, and conformational properties will be analyzed by surface topography and using the quartz crystal microbalance (QCM). The atomic force microscope (AFM) will be used to image the lateral structure of the adsorbed layers, while the interaction forces involving the dissolved natural compounds and surfaces will be studied by direct force measurements. Using the latter technique, both the adhesion mechanism and the mechanical properties of the organic layer will be investigated using a colloidal probe and tip-surface geometry, respectively. This protocol will allow systematic investigation of the physicochemical determinants of film development and conformation. The experimental data will be analyzed in the light of extended DLVO models. The complex systems are expected to give rise to nonelectrost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cu-As-Sb system: Determination of phase diagram' under Horizon 2020.

assistant: **Concept**

ASCUNISB will focus on the physico-chemical properties of copper (Cu) mined from sulfosalt minerals, which are characterised by high concentrations of arsenic (As) and antimony (Sb). Despite being the earliest produced alloy, the characteristics of Cu-As-Sb based alloys are poorly understood, and no phase diagram of such ternary alloys exist; consequently, material characteristics of such alloys are widely unknown. ASCUNISB aims to achieve the following research objectives:1) Build phase diagrams for Cu-As-Sb alloys with 1-40 at.% of As, Sb: investigate the phases of each alloy and identify unknown phases with desirable properties; understand initial phase formation, stability, and changes in alloys over the passage of time at different temperatures; explain and predict specific material behaviour during thermomechanical treatment; understand the effects of Sb addition on parent Cu-As alloys.2) Create a base for new applications: Cu-As based alloys have superior ductility and corrosion resistance than pure copper and other copper alloys. ASCUNISB will provide the data for Cu-As-Sb alloys to enable new applications in material engineering and find modern-day uses for them, and, consequently3) Reduce economic and environmental costs of refining and pollution: through new applications of the Cu-As alloys studied, As and Sb would not need to be removed from mined sulfosalt minerals;4) Provide a database for urgent research questions in prehistory: ASCUNISB will provide the data needed to assess the earliest metal technologies in prehistory and explain the adaption, recycling, and disregarded Cu-As alloys c. 2300 BCE.ASCUNISB applies an interdisciplinary approach by combining X-ray diffraction (XRD), differential thermal analysis (DTA), differential scanning calorimetry (DSC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of high-throughput pna-based molecular diagnostic systems' (EUPNA) under Fifth Framework.

assistant: **Objectives**

To improve gene mutation detection and screening in the clinical and research laboratories, the proposal aims at developing two fully automated molecular diagnostic systems based on high-throughput capillary electrophoresis (CE) and micro array biochips technology. These innovative systems will take advantage of:(1) the use of peptide nucleic acid (PNA) probes in hybridisation reactions;2) the implementation of a 96-capillary array electrophoresis device improved with novel CE coating and sieving matrices;3) the building of an innovative automated micro array work- station with laser scanner and microscope-based imaging systems and software; and4) the production of novel NIR-fluorescent dyes. These objectives will be achieved in combining the expertise, know-how, and resources of academic and industrial partners in a programmed fashion. This programme will result in the availability and, eventually, in the marketing of diagnostic systems that will make a measurable difference in research and clinical settings by delivering screening and diagnostic tests with high accuracy, reproducibility, reliability, and at a lower cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Neurocomputational Model of Episodic Memory' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Our memories define us, and their disruption in psychiatric and neurological conditions can be devastating. However, how we are able, e.g., to remember our wedding day and re-imagine the scene that was around us, remains one of the great mysteries of the human mind. NEUROMEM is an integrated experimental and computational attempt at a fundamental breakthrough in this problem. Building on recent insights into how environmental location and orientation is encoded by neurons in the mammalian brain, I aim to develop a mechanistic understanding of how events we experience are stored, recalled and imagined, i.e. a neurocomputational model of how specific memories result from patterns of activity in neuronal populations. NEUROMEM will provide mechanistic answers to 3 long-standing questions: 1) What is the link between memory and space, and role of spatial context in re-imagining episodes? 2) How are the multiple diverse elements of complex life-like events recollected together? 3) How can remembered events be read-out as visuospatial imagery? Work will comprise psychological and functional neuroimaging experiments using sophisticated designs including use of virtual reality, and corresponding simulations of how such behaviour can be driven by neuronal activity. The computational modelling will directly contact neurophysiological data such as the firing of place and grid cells in the hippocampal formation, and provide quantitative behavioural predictions, while neuroimaging provides a read out of population activity during this processing in the human brain. NEUROMEM will generate new hypotheses and explanations at the cognitive level, of interest to all scholars of the complexity of the human mind, and allow neurophysiological interpretation of behavioural data - providing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NEW FRONTIERS IN PLASMON OPTICS: FROM NANOCHEMISTRY TO QUANTUM OPTICS' (PLASMOLIGHT).

assistant: **Concept**

At this point in time where plasmon optics has become a mature field of research, we propose here to create new bridges with other scientific disciplines in which the optical properties of plasmonic nanostructures could successfully address major roadblocks.  The proposed scientific project consists of two independent parts, in which plasmonics is combined with Nanochemistry and Quantum optics, respectively.First, we will investigate how plasmonics could contribute to control with nanometer accuracy the deposition of a wide range of molecules or other nano-objects at a surface pre-patterned with noble metal nanostructures.  Our approach is foreseen to overpass some of the major limitations of existing methods by combining parallel patterning over large areas with a resolution down to 10nm. Beyond demonstrating the feasibility of this novel approach, we propose to exploit it to increase the sensitivity of bio-chemical plasmonic sensing and surface enhanced Raman scattering.The second part of the project will study the use of the recent concept of plasmon nano-optical tweezers to develop a novel integrated quantum platform. The developed platform will be tested for applications to quantum simulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Directed networks as a novel approach for improving the management of cardiac arrhythmias'.

assistant: **Concept**

The management of cardiac arrhythmia remains the largest problem in cardiac electrophysiology. The prevalence of the most frequent arrhythmia, atrial fibrillation (AF), is expected to rise steeply due to the ageing population. In spite of intensive research, the mechanism of atrial fibrillation remains unclear, leading to poor results in its treatment. Ablation of AF often results in complex atrial tachycardia (AT), which are difficult to treat. Also ventricular tachycardias (VT) and fibrillations (VF) are a major cause of sudden cardiac death. Again, eliminating  VTs with ablation has achieved only modest success in complex cases. Therefore, there is an urgent need to better understand and localize the sources of arrhythmia in order to improve its treatment. I propose a radical new approach of applying network theory to study the mechanisms of AT, VT and AF. Currently, network theory is known for being the basis for the Google search engine other online social networks, and has myriad applications throughout biology, physics, and social sciences. However, it has never been applied to the heart. In this proposal, based on my invention and preliminary work, I propose to apply network theory to clinical data of cardiac arrhythmia, backed-up by in-silico simulations. A new set of research tools will be created to automatically detect the source of the arrhythmia for complex AT and AF, which will identify possible ablation targets. For VT a substrate analysis is proposed, in order to reveal the structure of the heart to also determine the ablation target. My preliminary results already show that network analysis is able to automatically predict sites of ablation, prior to surgery in AT, largely exceeding the most recent technologies currently used in clinics. Therefore, thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Resolving the Perceptual Prediction Paradox' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Our sensory receptors are bombarded with noisy, continuous streams of information. From these streams, our brains must construct percepts that are (1) veridical representations of the world, and (2) informative – i.e., highlighting what we did not already know. Cognitive science has suggested that our brain meets these challenges by using probabilistic expectations to shape our perceptual experiences. However, there are currently two broad classes of theory concerning how expectations shape perception, that are both supported by large bodies of evidence and mutually incompatible: some theories propose that we upweight what we expect to generate veridical representations, whereas others propose that we downweight what we expect to privilege the most ‘newsworthy’ information. ConflictedPrediction will test a new theory addressing and solving this paradox for the first time, to determine how perception can be rendered both veridical and informative. I propose that probabilistic knowledge pre-emptively biases perception towards what is likely, to generate largely veridical experiences rapidly. However, if the input is particularly surprising, catecholamine release – acting to aid learning – reactively enhances perception of these inputs by modulating sensory gain. This perceptual enhancement will generate a clearer estimate of these highly unexpected events to guide model-updating. To test the theory, ConflictedPrediction will use temporally- and spatially- sensitive neural measures (EEG, MEG, 7T fMRI), in combination with computationally derived parameters of perception and unexpectedness. This interdisciplinary project therefore will unify understanding of perception and learning across typically isolated scientific domains. Its findings will chart a new research frontier
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'HGF/SF and MET in metastasis'.

assistant: **Concept**

The growth and motility factor HGF/SF and its receptor MET define a paracrine signalling system which controls the migration of several cell lineages in embryogenesis and tissue repair.  In a  large number of human tumours, cancer cells hijack HGF/SF and MET signalling in order to invade adjacent tissue and initiate metastasis. The evidence for this is strong, broad and consistent and highlights HGF/SF and MET as key effectors of tumour invasion and primary targets for therapy.   This proposal has two objectives. The first is to understand the mechanism by which HGF/SF and MET cause tumour invasion and, specifically: - how local hypoxia induces MET over-expression in tumour cells and how the MET - WNT and the MET - chemokine pathways cooperate in metastasis.  The second aim is to develop MET therapeutics. These will include:  (i) a protein antagonist built from a fragment of the ligand known as NK1,  (ii) low molecular weight MET antagonists and,  (iii) inhibitors of SHP-2, a critical effector of MET signalling. NK1 will be engineered as a receptor antagonist on the strength of available crystal structures. Low molecular weight MET antagonists and SHP-2 inhibitors will be developed on the strength of:  - the availability of recombinant forms of the target proteins,  - suitable screening methodologies and, -  the results of initial screens that have provided robust proof of principle for both approaches. The proposal thus builds on strong progress in participating laboratories on the structure and function of HGF/SF and MET and fulfils the three key criteria described in the call for proposal ‘Understanding and fighting metastasis’, namely:  (i) it addresses a key mechanism of dissemination of human tumours, (ii) contributes to understanding the interplay between the tum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Technology Enhanced Learning Leading to Unique Stories'.

assistant: **Objectives**

In many respects learning has been overtaken by the fundamental changes introduced by the information society and many Technology Enhanced Learning (TEL) innovations have yet to make their way into the classroom despite the fact that society is demanding change in what and how we learn.  This is the problem that the TELL US project seeks to mitigate by challenging learning providers in the form of an EU contest where new innovative TEL services will be shown across Europe to: education professionals, purchasers, students, and the general public.TELL US will demonstrate the range and quality of TEL products in order to enhance take up scalability, and encourage learning and education through these mechanisms.   The TELL US project will:\tcreate regional contests using our network of  EU countries/regions,\tbring regional winners together to compete for a Europe-wide prize in a Grand Final,\tShow through the contests approach how an already established or emerging TEL has been adopted and scaled-up in the formal leaning context.The TELL US consortium is uniquely placed to deliver this through its broad European reach and through the consortium members' close working ties with TEL stakeholders including pedagogical and cognitive experts.  Each partner is already engaged in activities with education professionals, TEL solution developers, providers, educators, procurers and learners.  The key impacts of TELL US will be to create demand through the valorisation of the use of TEL in education to suppliers, purchasers, consumers and educators throughout Europe leading to:\tA greater demand from schools and other formal educational institutes,\tA greater awareness and openness of educators to the possibilities of TEL ideas,\tA greater understanding of the products and sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Surface Urban Heat Island at High Spatio-Temporal Resolution' (SUHIST) under Horizon Europe.

assistant: **Objectives**

The fast growing of cities population in the last decades, which is projected to be continued in the following, requires a better understanding of urban climatology and atmospheric conditions, looking for the benefit of citizens life. In a fast warming world due to climate change, the UHI, defined as the temperature difference between the urban area and its surroundings, is a major concern in the cities. UHI has been traditionally studied with localised in-situ air temperature measurements, i.e., taking the difference between a representative value of the city and of the suburban area, thereby limited by its spatial representability. However, a deep comprehension of UHI spatial variability is essential for supplying policy-makers with high-quality information to plan, prevent and mitigate the UHI effect, especially relevant under extreme heat conditions. While satellite thermal infrared (TIR) data provided new valuable insights in surface UHI (SUHI), these are still limited by the compromise between the spatial and temporal resolution of TIR satellite sensors. In this action, we will develop a novel methodology to estimate high-accuracy (<2 K) land surface temperatures (LST) at unprecedent high spatio-temporal resolution, i.e. 100 m at four different times. The ADTC model will be applied to ECOSTRESS LST data, which will be refined in synergy MODIS LST data. The SUHI diurnal cycle will be evaluated over 24 European cities to analyse the SUHI variability at European cities with different climate characteristics. The project outcomes are expected to have a relevant impact on economy and society, since the high-resolution data produced in the project will be provided to policy-makers and to urban and health planning related sectors. In addition, findings from the project w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'N-point statistics as a bridge between cosmological observations and the underlying physics' to be submitted under Horizon 2020.

assistant: **Abstract**

Over the last decades, we have established a standard cosmological paradigm by combining the information from complementary cosmological probes. However, many intriguing questions remain to be answered: the nature of dark energy, the driving mechanisms of the cosmic inflation, and masses of neutrinos. In this proposal, I will focus on the cosmological information content of the large-scale structure (LSS) of the Universe. Different physical processes leave their unique imprints on the clustering pattern of LSS at different scales, and N-point statistics act a bridge between the observables and the underlying physics. In the coming years, new large-volume galaxy surveys will probe the LSS of the Universe with exquisite detail. However, traditional analysis methods, based mostly on 2-point statistics alone, are not adequate for these new surveys and must urgently be revised to ensure their full potential. This proposal aims to maximise the information to be extracted from the upcoming surveys. With the Marie-Curie fellowship, I will carry out a consistent joint analysis of the 2- and 3-point statistics, and develop a complementary but simplified treatment of the N-point statistics. These tools will be applied to the new data to constrain the cosmological models, with special focus in understanding the properties of the primordial signatures and models beyond the standard cosmological paradigm. In the outgoing phase, I will work at Univesity of Florida (US) to benefit from the expertise in the leading algorithms to estimate higher-order statistics, their theoretical modelling, and knowledge about high-performance computing. In the incoming phase, I will work at the Max Planck Institute for Extraterrestrial Physics (Germany), I will delve into the data from the real surveys