RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Deciphering the molecular dynamics of centriole and centrosome biogenesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Centrosomes are organelles composed of a pair of centrioles surrounded by a pericentriolar matrix (PCM) that perform a variety of key functions in the animal cell. Centrosomes duplicate precisely once during S-phase of the cell cycle; in G2-phase the two centrosomes move to opposite locations around the nucleus and expand their PCM to nucleate vast quantities of microtubules for mitotic spindle formation. Dysfunctions in the centrosome cycle have been associated with a wide range of pathologies and, in particular, centrosome amplification, an aberrant increase in centrosome numbers, is a hallmark of most human cancers. Centrosomes are complex machines composed of hundreds of proteins, however significant efforts over the past decades have identified the key elements which are essential for centriole and centrosome biogenesis. We can now address the molecular mechanisms that mediate interactions between key players and how these contribute to regulate the number and size of these organelles during the cell cycle. Elucidating these mechanisms is of great interest to cell biology and cancer research. This research proposal aims to investigate aspects of centriole and centrosome biogenesis using Drosophila melanogaster as an animal model. The main objectives are: 1), to reconstitute initial steps of centriole assembly using a hybrid in vivo/in vitro approach, where I will study the molecular dynamics of the interaction between key centriolar proteins Asl and Plk4, using functionalised microspheres as a scaffold and 2), to analyse the dynamic behaviour of single molecules of key centrosomal proteins Cnn and Spd-2 as they move throughout the PCM during expansion, using super-resolution microscopy techniques. We are confident that these studies will provide novel insights into
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Technological Intelligence for MEchanics network' under Fifth Framework.

assistant: **Concept**

The proposal is submitted by a consortium of 7 partners, all specialised in R&D assistance, promotion of innovation, technology transfer and internationalisation (all host an Innovation Relay Centre, three of them also a National Contact Point or a regional NCP). The aim is to improve competitiveness of SMEs through the participation in the Growth" Programme in the mechanics sector, one of the most important for Europe, characterised by a wide diffusion of family based micro-companies, often subcontractors. Thus, this sector will strongly benefit from a wider participation in the 5th FP. Another objective is to valorise expertise present at regional level by promoting technological and economic synergies and transnational collaboration among SMEs. The construction of a mechanics network on the Web will facilitate this task. The expected results are 35-40 RTD EC proposals submitted and 250 companies involved in the mechanics network."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'ILLUMINATING ROUTES TO 3D ORGANOBORON MOLECULES'.

assistant: **Objectives**

With a steadily growing, aging population, there is significant strain on the pharmaceutical sector to produce state of the art therapeutics for societal needs whilst respecting the finite resources provided by the environment. Prominent advances in drug design are reliant on chemical synthesis platforms allowing the efficient exploration of chemical space to discover next generation functional molecules. As a result, innovation is currently limited by the practical implementation of enabling methods, which often becomes the rate limiting factor in cutting-edge research: this is more pronounced when translating academic research to industrial settings. The current renaissance of organic photochemistry and light-driven processes in a broader sense provide an opportunity to reconcile the growing demand for new functional molecules with consideration of sustainability and atom economy. Inspired by the importance of organoboron motifs in medicinal chemistry, this EU action “LUMIBOR” will harness the untapped potential of boron hybridization and boron ligand design to unlock new excited state reactivity paradigms and thereby facilitate the discovery of new methods to access achiral and chiral 3D organoboron scaffolds. LUMIBOR will create a structural platform to utilize boron hybridization in the development of next generation light-enabled ACTIVATION methods. Understanding the correlation between hybridization and parameters such as excited state energy and adjacent bond dissociation energy will allow access to synthetically versatile, high-energy intermediates such as α-boryl radicals and the triplet excited state. Strategic control over boron hybridization will also be utilized to regulate REACTIVITY, by influencing radical philicty, spin density, and excited state lifeti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Potential for use of renewable sources of energy in Asia and their cost effectiveness in air pollution abatement' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This project aims on the promotion of renewable forms of energy in China and India by quantifying their potential beneficial role in air pollution abatement policies. This should be achieved by an integrated assessment of the costs and the environmental impacts of renewable forms of energy, particularly in comparison with other fossil fuels.Major aspects of the project are:* An assessment of the potential for renewables by a detailed bottom-up analysis of the energy demand, taking into account the economic heterogeneity within countries and economic sectors, as well as the costs of different energy systems.* An analysis of the costs of emission control through use of renewable fuels. These will be compared to costs of individual control technologies for fossil fuels, as well as of alternative strategies to avoid acidification problems in Asia.* Development of a policy analysis tool for exploring cost-effective strategies for air pollution abatement, in particular focusing at the role of renewable energy.* Creating expert capacity in China and India to assess the potential role of renewable energy sources in air pollution abatement strategies.Expected OutcomeThis project will result in scenarios for use of renewables in China and India, including a business-as-usual scenario and a policy scenario in which use of renewables is encouraged. In addition, the cost-effectiveness of strategies for air pollution abatement will be explored. The results of the study will be used as input to one of the workshops, leading to policy recommendations with respect to use of renewables.The project consists of the following work packages:1. The first work package includes a bottom-up analysis of the potential demand for renewable sources of energy in China and India. The potential for ren
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GLP1-R Agonists in Pregnancy- Impact on Baby's Brain' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Obesity and associated metabolic diseases represent a significant health challenge and financial burden worldwide. Recently, a breakthrough has been made in the treatment of obesity with drugs such as semaglutide (Ozempic), which mimic endogenous glucagon-like peptide 1 (GLP1) action in the brain and cause weight loss via reduced food intake. The hypothalamus is the key brain region involved in the neuronal control of food intake. Recent research shows that perturbations to the maternal environment in pregnancy may interfere with early neural circuitry development in offspring and lead to life-long metabolic impairments that are a contributing factor of rising obesity rates. The increased Ozempic use in women of reproductive age has resulted in a rise in “Ozempic babies”, where women unexpectedly become pregnant whilst using Ozempic. However, there is limited data regarding Ozempic use in pregnant women to determine whether in utero exposure leads to adverse developmental effects in offspring. The offspring hypothalamus is potentially vulnerable to semaglutide exposure, due to it’s highly plastic developmental state and high GLP1R expression in both rodents and humans.  This project is designed to test the hypothesis that in utero Ozempic exposure causes significant alterations to the development of hypothalamic feeding circuitry resulting in subsequent disruptions to metabolic control in the offspring. Using a rodent model of semaglutide administration to the mother in pregnancy, we will determine whether semaglutide exposure during fetal development affects hypothalamic circuitry and transcriptome at different ages from fetal through to adult life and evaluate whether semaglutide exposure causes long-term changes in metabolism or feeding behaviour in offspring in adul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanofabrication of strongly gain coupled lasers for high speed communication and sensor applications' (NANOLASE) under Fourth Framework.

assistant: **Objectives**

In the present project leading research institutes in the field of microfabrication for optoelectronic devices and major telecommunication companies will make a co-ordinated effort to develop gain coupled laser structures for telecommunication and sensor applications, which are based on nanopatterning of the active material of the devices.In the GaInAsP/InP material system single mode lasers based on gain coupling at 1.55 µm are promising light sources for high speed modulation due to a large bandwidth and a small chirp. Gain coupling is expected to improve significantly the yield of monomode lasers compared to index guided distributed feedback lasers without requiring anti reflective coatings and phase shifted gratings. This makes gain coupled lasers especially attractive for wavelength multiplexing applications.Using GaAs based heterostructures, single mode gain coupled lasers in the 0.8 µm range will be developed for sensor applications. Here the development focuses on a high side mode suppression ratio and narrow linewidths. In both wavelength ranges the potential of gain coupling for low cost monomode lasers will be evaluated.Gain modulation will be obtained by holographic and electron beam exposure in combination with etching as well as by focused ion beam patterning. In particular the patterning of first order gain coupled structures is very challenging, because the gain sections for lasers at 1.55 µm and 0.8 µm have widths on the order of 100 nm and 50 nm, respectively. For example, ultra low damage processes have to be developed for the different materials.Broad area lasers, ridge wave guide lasers and buried heterostructure lasers will be developed from overgrown first order gain grating structures. The gain coupled lasers will be evaluated in the laboratories
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Concepts and Science for Coastal Erosion Management' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The strategic objective of the CONSCIENCE project is to develop and test concepts, guidelines and tools for the sustainable management of erosion along the European coastline, based on best available scientific knowledge and on existing practical experience.The first aim of the project is to define a decision-making framework based on the concepts formulated by the EUROSION project, i.c. coastal resilience, coastal sediment cells, favourable sediment status and strategic sediment reservoirs. The second aim is to develop these concepts into measurable standards, which can be evaluated in practice for any field situation. The third aim is to link these standards to ongoing European initiatives as GEO/GMES, the European Soil Strategy in preparation, The European Maritime Strategy and the Recommendation on Integrated Coastal Zone Management. The fourth aim is to produce guidelines and tools to enable an effective implementation in European coastal management.The practical applicability and effectiveness of the guidelines and tools will be evaluated in selected test sites. It is envisaged that the combination of the decision-making framework and the provision of guidelines and tools will prove highly valuable to coastal managers when deciding on the most sustainable method of managing erosion at any given location.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pricing acceptability in the transport sectors' (PATS), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to:- Identify the reasons behind the attitude of acceptance/non-acceptance of transport pricing, and the arguments that support those standpoints;- Find the means and measures to increase its acceptability;- Identify the legal and political barriers to the implementation of pricing schemes;- Analyse the distributional impacts;- Design acceptable pricing schemes and policy packages, taking account of efficiency and fairness issues.PATS project aims to bring new and deeper knowledge of the conditions necessary to enhance acceptability of pricing schemes to the transport sector by integrating those requirements in the underlying structural environment. The economic relevance of the research lies also in its added value in enabling a more market oriented approach, through the knowledge of the reasons for opposition and acceptability of pricing schemes, which in turn enables the improvement of the organisation and management of the transport systemsPATS research project is subdivided into five work packages (WP1-WP5), which are linked together in a consecutive logical order where the results from earlier work packages are used in the subsequent ones: - WP1 State of the art review- WP2 Socio-economic principles for price acceptability- WP3 Empirical studies on price acceptability.- WP4 Design acceptable solutions for pricing packages.- WP5 Transport Pricing Strategies - Conclusions and Recommendations %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Management of Hypotension In the Preterm Extremely Low Gestational Age Newborn' under Seventh Framework.

assistant: **Concept**

Assuming an annual birth rate of 10.25 births/1,000 population approximately 25,000 Extremely Low Gestational Age Newborns are born every year in the EU. Conservative figures estimate that approximately half of all these babies will develop low blood pressure and require treatment. However, no uniform criteria exist to define hypotension and the evidence to support our current management strategies is limited. Many of these interventions have been derived from adult literature and have not been validated in the newborn. Dopamine remains the most common inotrope used despite little evidence that it improves outcome. Hypotension is not only associated with mortality of preterm infants but is also associated with brain injury and impaired neurosensory development in ELGAN survivors. Preterm brain injury has far reaching implications for the child, parents, family, health service and society at large. It is therefore essential that we now design and perform the appropriate trials to determine whether the infusion of inotropic agents is associated with improved outcome. We have assembled a consortium with expertise in key areas of neonatal cardiology, neonatology, neurophysiology, basic science and pharmacology with the intention of answering these questions. The objectives of the group are as follows:1. To perform a multinational, randomized controlled trial to evaluate whether a more restricted approach to the diagnosis and management of hypotension compared to a standard approach, with dopamine as a first line inotrope, affects survival without significant brain injury at 36 weeks gestational age in infants born less than 28 weeks gestation and affects survival without neurodevelopmental disability at 2 years corrected age2. To perform pharmacokinetic and pharmcodynamic s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transport Jars and Commodity Exchange in the Late Bronze Age Argolid: Tiryns and Midea' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project will provide major insights into commodity exchange and maritime links, in the Bronze Age Aegean world and Eastern Mediterranean, through the detailed analysis and publication of Transport Jars of LHIIIA-LHIIIC date in the Argolid, Greece. Building on important new evidence from the major citadels of Tiryns and Midea, it will use thin section petrography and chemical analysis to ascribe provenance to transport jars of the late 14th to 12th centuries BCE. Recent work on transport amphorae and notably Transport Stirrup Jars (TSJs) has demonstrated the great potential of integrated petrographic and chemical analysis to answer questions on the provenance of ceramics and their contents (e.g. Haskell et al. 2011; Day et al. 2011), the latter work concentrating on Crete. Now, transport jars including TSJs, Canaanite amphorae, Cypriote and Attic, will be analysed and compared to the extensive, comparative datasets held by the Sheffield – NCSR ‘Demokritos’ research team, which covers not only the Aegean, but relevant material from much of the Central and Eastern Mediterranean. This important, diachronic ceramic evidence will be used to trace contact between the Argolid, Crete, Cyprus and the Levant both during the life of the Mycenaean Palaces and immediately after their demise. Tiryns and Midea provide an unrivalled resource for such work and it will produce the first fabric-based work on major deposits from these sites. In a dynamic partnership with Higher Education and public institutions, Dr Marta Tenconi, the proposed IEF, will illuminate commodity exchange in the Argolid, the core area of the Mycenaean world. The research will lead to major academic publications, dissemination to the public by national press and a museum outreach programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Magnetic identification', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project consortium consisting of BOGEN (project coordinator, SME), INESC-MN (research), and INSPECTRON (SME) will bring the novel identification solution for track & trace, anti-counterfeiting and product verification to market. INSPECTRON has recently developed a magnetic ink barcode reader and has implemented this in a mailer project. BOGEN has developed with INESC-MN a new technology to read magnetic ink with TMR sensing technology. Combining these approaches results in a disruption for the identification and authentication/anti-counterfeiting markets with Mag-ID, the magnetic readable barcode based on ink. The objective of this action is to introduce Mag-ID as a cost-efficient alternative for high volume tracking & tracing, brand protection and inspection and to replace passive RFID as a cheap solution for high volume applications. Since magnetic barcodes are dirt resistant, the technology will replace some barcodes with a more reliable read. The technology allows for distance reading, which means that the information can be read through coatings, e.g. parts before and after a paint booth can be identified automatically with the same technology. This can be used for tracking and tracing of components in a subassembly e.g. in identification documents to ensure that personal data and pictures are matched in the process and after assembly. Together with a verification as a service platform, SMEs can provide authentication and validation services world-wide. Magnetic barcodes can replace many RFID solutions as they are environment-friendly without separate electronic device disposal. Within Mag-ID, the SME partners will demonstrate the results manifold: BOGEN Mag-ID one-shot reader in a volume application, INSPECTRON with evaluation modules for the Mag-ID brand prot