RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated access to balloon-borne platforms for innovative research and technology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

HEMERA will integrate a large Starting Community in the field of tropospheric and stratospheric balloon-borne research, in order to make existing balloon facilities available to all scientific teams in the EU. The project involves major space agencies dealing with balloon infrastructures, companies operating the balloons, companies providing the necessary technology and scientific experts.Balloon borne instruments are suitable for a wide range of science fields, such as atmospheric measurements, climate and environment related investigations, astronomy and astrophysics, space instruments validation and testing of new technologies.The objectives of HEMERA are to:- Provide better and coordinated balloon access to the troposphere and stratosphere for scientific and technological research- Attract new users to enlarge the community accessing the balloon infrastructure- Enlarge the fields of the science and technology research conducted with balloons- Improve the balloon service offered to scientific and technical users- Favour standardisation, synergy, complementarities and industrialisation through joint The infrastructure deals with a wide range of mission characteristics including altitude, flight duration, instrument mass and volume. Flights can be performed during all seasons at various latitudes, satisfying various scientific needs. Currently, the HEMERA programme will use the Zero Pressure Balloons for stratospheric flights (relevant for measuring Essential Climate Variables and for astrophysics), additional types of balloons can be considered. HEMERA will give access to launch bases and is thus capable of conducting scientific balloon campaigns, in Europe and abroad, necessary in particular for scientific issues in the context of climate change. HEMERA includes 3 ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unraveling the chemistry of the lithium-air battery by novel solid state NMR techniques' in the context of a Seventh Framework call.

assistant: **Objectives**

Lithium–air (Li-air) batteries have potentially much higher gravimetric energy storage density compared to all other battery chemistries. If successfully developed, this (charged) battery could compete with gasoline as an energy source for electric vehicles. However, in order to fulfill its promise and satisfy the key criteria for a practical electric vehicle propulsion battery, numerous scientific and technical challenges must be overcome. These include the voltage gap between the charge and discharge, inefficient cycling and limited practical specific energy. Like other battery technologies, its performance can be significantly improved by understanding the fundamental battery chemistry occurring during the electrochemical cycle. In the case of the Li-air battery the discharge and charge mechanisms are strongly dependent on the choice of electrolyte solvent, the presence of catalytic species in the cathode, which decrease the charging potential and surprisingly affect the capacity, and the porosity/surface area of the composite carbon cathode.  A quantitative understanding of the electrochemical reactions (and parasitic side reactions) during the cell cycle is a necessary aspect in the development of a practical rechargeable Li-air battery. Nuclear magnetic resonance (NMR) can allow us to monitor these chemical processes, providing unique molecular and atomic information on these often disordered and amorphous materials. Here we propose to apply existing and novel solid state NMR techniques in the study of Li-air batteries under ex-situ and in-situ operating conditions. By real time monitoring of the formation and disassociation of lithium containing species we expect to derive a mechanistic description of the cell's chemistry in the presence of various electrolyte en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of solar-grade silicon feedstock for crystalline wafers and cells by purification and crystallisation' (FOXY).

assistant: **Innovation**

Within the FoXy" project, a Europe-wide consortium consisting of small and medium size enterprises, industry, research institutes and universities, intends to support the European goals for the Photovoltaic (PV) industry of decreasing module costs to Euro 1/Wp in 2010 and to have 3 GWp PV installed in 2010. Under the realistic assumption that Si-wafer based PV modules will dominate the market in the coming decade, the FoXy partnership will answer the need of the PV market for low price- and high quality SoG-Si feedstock by: 1. Further developing and optimising refining, purification and crystallisation processes for metallurgical SoG-Si feedstock, as well as recycled n-type electronic grade Si. 2.Optimising associated cell and module processes. 3.Settin g input criteria for metallurgical and electronic n-type silicon as raw materials for SoG-Si feedstock. 4.Transferring the technology from laboratory to industrial pilot tests. Through the proposed EU project collaboration, the FoXy consortium will develo p a close partnership along the whole value chain from feedstock to module production. This lays a foundation for new investments in SoG- Si feedstock production and subsequent commercial use of the material produced. Metallurgical silicon, solar grade si licon and recycled material from new and unexploited sources, will be refined to acceptable purity through electrochemical, metallurgical and physical methods under development. The refined SoG-Si material cost target is below 15? per kg. Subsequent direc tional solidification and Czochralski crystal pulling will be optimised with respect to efficiency and yield. Advanced solar cell processing techniques will be developed on thin (200µm) large area (150x150mm2) wafers aiming at 17% cell efficiency. Materia l and unit c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DE NOVO GENERATION OF SOMATIC STEM CELLS: REGULATION AND MECHANISMS OF CELL PLASTICITY' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The possibility to artificially induce and expand in vitro tissue-specific stem cells (SCs) is an important goal for regenerative medicine, to understand organ physiology, for in vitro modeling of human diseases and many other applications. Here we found that this goal can be achieved in the culture dish by transiently inducing expression of YAP or TAZ - nuclear effectors of the Hippo and biomechanical pathways - into primary/terminally differentiated cells of distinct tissue origins. Moreover, YAP/TAZ are essential endogenous factors that preserve ex-vivo naturally arising SCs of distinct tissues. In this grant, we aim to gain insights into YAP/TAZ molecular networks (upstream regulators and downstream targets) involved in somatic SC reprogramming and SC identity. Our studies will entail the identification of the genetic networks and epigenetic changes controlled by YAP/TAZ during cell de-differentiation and the re-acquisition of SC-traits in distinct cell types. We will also investigate upstream inputs establishing YAP/TAZ activity, with particular emphasis on biomechanical and cytoskeletal cues that represent overarching regulators of YAP/TAZ in tissues.For many tumors, it appears that acquisition of an immature, stem-like state is a prerequisite for tumor progression and an early step in oncogene-mediated transformation. YAP/TAZ activation is widespread in human tumors. However, a connection between YAP/TAZ and oncogene-induced cell plasticity has never been investigated. We will also pursue some intriguing preliminary results and investigate how oncogenes and chromatin remodelers may link to cell mechanics, and the plasticity of the differentiated and SC states by controlling YAP/TAZ.In sum, this research should advance our understanding of the cellular and molecul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantifying the impact of Tropospheric Chlorine Oxidation Chemistry' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This project addresses a fundamental and yet highly unconstrained question in atmospheric chemistry: What is the impact of atomic chlorine on the composition of the troposphere?Gas phase oxidants control the concentrations of important climate and air pollutants such as methane, ozone and particles. Accurate representation of oxidation chemistry in computational models is paramount to our ability predict and understand past, present and future changes to the Earth system. Over recent decades there have been continual suggestions that the chlorine atom may be a significant tropospheric oxidant, but a lack of observations capable of constraining its chemistry mean that its role remains highly uncertain. Without these underpinning observations, our understanding of atmospheric oxidation and thus our ability to develop effective and timely policies to address air quality and climate change is compromised.This project will provide a step-change in our understanding of atmospheric chlorine chemistry. Capitalising on recent technology advances, two innovative instruments capable of definitively constraining chlorine atom sources and sinks will be developed. These instruments will be deployed at three chemically contrasting locations (Cape Verde, coastal Netherlands and central Germany), generating the first comprehensive dataset on tropospheric chlorine atom production and loss. These data will be used to challenge the state-of-the-science representation of chlorine chemistry in atmospheric chemistry models. Ultimately this work will advance our understanding of the fundamental chemistry occurring in the atmosphere and help to direct developments in the next generation of air quality and climate models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'NONLINEAR GLOBAL CHANGE DURING THE LAST 6 MILLION YEARS : A MULTIVARIATE THRESHOLD MODEL FOR PLIO-PLEISTOCENE CLIMATE'.

assistant: **Objectives**

Research objectives and content Quantifying the future behaviour of the climate system due to an anthropogenically induced greenhouse trend" is an important field in current climate research. In this project the global Plio-Pleistocene climate evolution is investigated, which consists of several transition steps from a "greenhouse" to an "icehouse" climate. The observations show that also on Plio-Pleistocene time scales we face a complex climate system whose variables (ice volume, atmospheric carbon dioxide, etc.) interact nonlinearly and produce multiple and abrupt transitions, including threshold phenomena. In order to yield a better understanding of the role of the significant climate variables and their interactions for climatic changes, it is essential to incorporate, in addition to simple dynamical models, time series models into the stochastic description of climatic variability. Therefore, a multivariate threshold time series model for Plio-Pleistocene climate shall be developed. The nonlinear threshold and multivariate form accounts for the observed complex phenomena. It will constitute the first time series model for Plio-Pleistocene climate and the first application of climate data to multivariate threshold modelling. We expect answers to the following questions: (1) which climate variables play (at what time) a major role, (2) what is the degree of their interaction, (3) are the observed Plio-Pleistocene climate transitions accompanied by changes in thec threshold model parameters, (4) what kind of stochastic components have an influence, (5) how good is the prognostic capability of the model. Training content (objective, benefit and expected impact) Our previous work on Plio-lPleistocene climate time series analysis (Mudelsee and Stattegger 1996) and dynami
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interpretable Artificial Intelligence across Scales for Next-Generation Cancer Prognostics' (AIS-CaP).

assistant: **Innovation**

Computation pathology has the potential to revolutionize cancer care and research, specifically through improving assessment of patient prognosis and treatment selection by applying advanced machine learning methods to digitized tissue sections, i.e. whole-slide images (WSIs). This will allow us to replace the current state-of-the-art of human-developed cancer grading systems. However, the field is currently hindered by significant knowledge gaps: we do not know how to effectively leverage both global and local information in WSIs, how to identify pan-cancer prognostic features, and how to make machine learning models explainable and interpretable. In this project, I will address these key knowledge gaps by building on the novel stochastic streaming gradient descent developed in my group. Specifically, I will integrate innovative multi-task and cross-task learning algorithms with SSGD. Furthermore, I will leverage the latest advances in self-supervision, self-attention and natural language processing to endow deep neural networks with unprecedented transparency and explainability. Last, the project will validate our developed methodology in the largest dataset of oncological WSIs in the world, and, for the first time, identify links between morphological prognostic features and genetic features. By publicly releasing all developed tools and data, the proposed project will have a scientific multiplier effect for the fields of oncology, computational pathology and machine learning. Specifically, the derived cancer-specific and pan-cancer biomarkers can be leveraged in clinical care and cancer research, the enhanced SSGD method for other tasks in computational pathology and our novel multi-task and explainability algorithms can impact other research areas in machine learni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Crack growth behaviour of low alloy steel for pressure boundary components under transient light water reactor (LWR) operating conditions'.

assistant: **Innovation**

The proposal addresses the ageing of primary pressure boundary components of nuclear power plants by environmentally assisted cracking. In particular, it deals with the crack growth behaviour of low alloy steels for reactor pressure vessels (eastern and western type) in light water reactor environment under static and cyclic load. Besides different crack geometries and specimen sizes transient conditions as postulated for plant operation will be considered during the test by varying water chemistry and mechanical load. The initiation of environmentally assisted cracking in pre-fatigued specimens will be forced by cyclic loading in the test environment. The results will lead to recommendations for service operation and for Code implementations. They will broaden the database for the lifetime assessment of nuclear power plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Electronic structure of nanosystems: Density functional theory approach' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

One of the core concepts in nanoscience and nanotechnology is the bottom-up approach, taking electrons, atoms, or molecules as the building blocks from which to create man-made nanosystems with the specific and desired electronic, biological, material, mechanical, or environmental properties. This approach however, poses a new and fundamental scientific challenge: the mastering of the way in which electrons, atoms, or molecules interact which each other, governed by the non-intuitive laws of quantum mechanics. This challenge drives in turn the search for better and accurate calculation methods aimed to the prediction, with the largest reliability as possible, of the properties of a particular array of electrons or atoms (nano-design).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The declarative style as a way to unify the object-oriented and concurrent paradigm of programming' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

While the theory of object-orientation and the theory of concurrency have been widely and intensively studied, and now they are very well known and under control, the attempts to integrate these two different views of systems have been recent and with little success. The necessity of having object-oriented concurrent languages is universally accepted since now it is clear that concurrent or object-oriented languages have an expressivity which is insufficient as an extension of the project 'Integrating static and dynamic aspects in the specification of object-oriented and concurrent distributed systems' - Human Capital and Mobility Cat 20. fellowship, contract ERBCHBICT941002, proposal ERB4001GT931544. With respect to other approaches towards the integration of object-orientation and concurrency, our approach is distinguished to the extent that we have a larger view of the so-called 'object paradigm' which, for us, consists of specification, programming and refinement in the context of objects, classes, inheritance and concurrency. Our approach towards this larger integration is algebraic, with the declarative style based on equational reasoning as the way to express both the object-oriented and the concurrent view. There are several reasons for preferring an algebraic approach. Perhaps the most compelling is the extensive algorithmic for term rewriting, unification, narrowing and completion, and theorems for the completeness of equational reasoning with respect to algebras, and the soundness of constructor induction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Imaging of the neural stem cell origin, proliferation, and fate within the stem cell niches of the mammalian brain' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Neural stem cells provide throughout life a source of neuronal and glial progenitors in the central nervous system of mammals. In the adult brain, stem cells reside in specialized ‘niches’ which contain molecular and cellular signals capable of regulating their symmetric/asymmetric division, as well as specification and fate of their progeny. In the major neurogenic site, the forebrain subventricular zone (SVZ), the neural stem cells have been identified as a subpopulation of astrocytes originating from the embryonic radial glia. Occasionally, some of these astrocytes divide to give rise to transit amplifying cells that actively proliferate thus generating a neuronal, and to a lesser extent glial, progeny. Yet, the very mode, time, and pattern of cell division, as well as the mechanisms involved in its regulation within the stem cell niche are poorly understood. In this project, several techniques of living cell imaging and tracing, cell proliferation detection, and light, confocal, electron microscopic morphological analyses will be combined with the aim of visualizing and studying in vivo the process of neural stem cell division. Since brain neurogenic niches remarkably change postnatally, neural stem cell division will be analysed at different postnatal stages, through the transformation from radial glia to neurogenic astrocytes. These objectives, other than representing a crucial step in further understanding the neural stem cell biology within their niches, could be of importance in allowing new strategies aimed at modulating in situ the behaviour of mammalian neural stem cells as an innovative approach to brain repair.