RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'General and targeted approaches to unravel the molecular causes of type 2 diabetes' in the context of a Seventh Framework call.

assistant: **Objectives**

Type 2 diabetes (T2D) affects worldwide at present about 250 million patients and an estimated 380 million in 2025. This epidemic has been ascribed to a collision between genes and an affluent society. Genetics of T2D has during recent years identified > 30 variants increasing susceptibility to T2D. Yet, these variants explain only 15% of the heritability of T2D. One reason could be that whole genome association studies can only detect common variants whereas identification of rare variants with stronger effects would require sequencing. A large part of this application is devoted to sequencing of affected family members from unique large pedigrees traced back to common ancestors around 1600. The advantage of using families is that identified variants can be tested for segregation with the trait. Genetic variants can influence expression of a gene in an allele specific manner. This will be explored by combining exome sequencing with sequencing of RNA from human islets.Impaired effects of the incretin hormones GLP-1 and GIP on the pancreatic islets represent central defects in T2D. Variants in the TCF7L2 and GIPR genes contribute to these defects. I will here explore the molecular mechanisms by which TCF7L2, the strongest T2D gene, causes T2D. GIP has unprecedented effects not only on islet function but also on body composition, blood flow and vascular complications in T2D. This application explores these effects and will test whether manipulation of GIP can mimic the normalization of glucose tolerance seen after gastric bypass surgery.Taken together, these general and targeted approaches are expected not only to provide new insights into the causes of T2D but also contribute with vital information for development of new treatments for T2D.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New molecular targets and proof-of-concept therapies for Autism Spectrum Disorders' (THERAUTISM) under Horizon 2020.

assistant: **Objectives**

Autism is the major neurodevelopmental health public issue, affecting 1/100 child births worldwide. These disorders are diagnosed before the age of 3, based on behavioural cues: deficits in social interaction and communication as well as stereotyped and restrained behaviours. There is no medication to improve this condition. Most recent molecular targets identified within narrow frameworks (unspecific molecule, single tissue targeted, single disease model used) have failed in clinical trials. My first objective aims at thwarting this autism research gap, unravelling the common molecular and cellular dysfunctions underlying autism-related behaviours across several preclinical models and neuronal circuits. In particular, setting up translatomic analyses in these paradigms will identify and validate new molecular therapeutic targets. I recently deciphered one such molecular substrate, involving the loss of oxytocin transcripts in oxytocinergic axon terminals thus demonstrating the feasibility of this global approach. The second major objective of my project is to hijack the properties of a newly identified protein function to restore this new target and rescue social deficits in different preclinical models of autism. This would yield a novel and safe gene therapy vector which has never been explored before. Altogether, my research project will deliver strategic resources to the scientific and medical communities that will spur the development of new treatment options for autistic patients.


**Keywords:** Autism,  ASD,  translatome,  oxytocin,  Arc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Breast biopsy system guided by Positron Emission Mammography allowing real-time 3D visualization of tumour lesion and needle insertion guidance for higher sampling accuracy and efficiency' to be submitted under Seventh Framework.

assistant: **Abstract**

Breast cancer is the most frequent cancer among women and one of the leading causes of cancer-related mortality and early diagnosis is essential to reduce the risk of mortality. First diagnostic tool is clinical imaging (mainly Mammography and Ultrasound) but suspicious findings usually require a biopsy to confirm the diagnosis; 2% of women who undergo a screening mammogram will require some type of breast biopsy (1,3 million women each year in Europe).Breast biopsy is an image-guided procedure that can use different imaging technologies. Apart from US-guided biopsy, which is a manual procedure with limited indications, all current solutions are based on discrete scans of static images taken at different steps during the procedure. This guidance method makes current biopsy techniques to be long procedures with limited accuracy.MAMMOCARE project will develop a PEM (Positron Emission Mammography)-guided breast biopsy system allowing real-time 3D visualization of the lesion and real-time guidance with continuous monitoring of both, lesion position and needle motion. The system will also allow for preoperative planning of the optimal needle path. Exclusive PEM technology used, having the highest sensitivity and spatial resolution in the market, will allow the detection of small lesions difficult to find with conventional morphological imaging technologies, contributing to earlier diagnosis.Real-time monitoring and control of biopsy procedure, together with the high precision mechanics of the biopsy positioning module will assure an accurate sampling of the target lesion as well as shortening the procedure with regard to current techniques.Thus, the consortium will offer an integral diagnosis system based on PEM Imaging, including a biopsy module compatible with this kind of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Three Regional Operational networks working on Strategic Electronic Scenarios'.

assistant: **Objectives**

The objective of Three Roses is to prepare a large integrated project that contributes to the cohesive development of local and regional digital economies. This is achieved in strong alignment with the objectives of Action Line II.1.2, through an effective definition and exploitation of e-business and e-work research, with particular focus on e-commerce and e-services in which local and regional government and public-private partnerships play a central role. Three Roses builds on the unique combined strength of the three main local/regional networks working on the information society and implements an integrated work programme that generates and disseminates relevant knowledge; creates a constituency of RTD stakeholders through consensus building on RTD challenges, roadmaps, constituencies and implementation models for major future business and work challenges; and integrates the results of related European projects.OBJECTIVESThis is achieved through an effective definition and exploitation of e-business and e-work research, with particular focus on e-commerce and e-services in which local and regional government and public-private partnerships play a central role. For this, Three Roses implements an integrated programme that: generates and disseminates relevant knowledge; creates a constituency of RTD stakeholders through consensus building on RTD challenges, roadmaps, constituencies and implementation models for major future business and work challenges.DESCRIPTION OF WORKThree Roses implements a constituency-building programme structured into 5 work packages. Besides management and coordination activities, monitoring and evaluation activities review and guide the realisation of the project's objectives. Generation of knowledge involves studies, surveys, reviews, crit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantitative magnetic imaging of thin films with reduced dimensions' under Fourth Framework.

assistant: **Concept**

Magnetic thin films with reduced dimensions are of considerable interest in terms of fundamental micromagnetic studies, applications to the magnetic recording industry and use as probes in magnetic force microscopy (MFM). In this project it is proposed to study thin films with reduced dimensions, by the methods of Lorentz microscopy, for two distinct systems; (i) elements with micron and sub-micron planar dimensions fabricated by electron beam lithography and (ii) MFM tips produced by coating substrates with reduced dimensions with thin films. In (i) it is intended to look at a number of different magnetic materials with varying magnetic properties in order to gain an insight into the micromagnetic behaviour of thin films with reduced dimensions. It is expected that the magnetic properties of the elements can be tailored by suitable choice of material. The principle objective in (ii) is the magnetic characterization of MFM thin film tips for a number of different systems. At present MFM imaging is limited by the fact that image interpretation is restricted due to the poorly understood tip-sample interaction. It is expected that significant progress in making MFM image interpretation quantitative will be made by studying the behaviour of thin film tips by Lorentz microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular and genetic analysis of pp2/tkf - a gene with several functions during the development of drosophila' (1994-1998).

assistant: **Innovation**

Research objectives and content A new gene was identified in the host laboratory and preliminary n PP2/tkf. During embryonic development PP2/tkf is required for he correct formation of the muscle pattern and for the determination of the photoreceptor identify. We will analyse the structure of this gene and the nature of its protein product and will determine its position in the pathway leading to muscle and eye development in the larvae and the adult, respectively. To accomplish this we will: (1) Complete the characterization of the molecular organisation of the PP2/tkf locus as well as identication of the products encoded by the gene. (2) Study the function of PP2/tkf during embryonic development in the muscle and the tracheal systems. (3) Analyze the mechanism of action of PP2/tkf, studying the regulation of the gene as well as the biochemichal functions of the protein. (4) Correlate the different phenotypes that appear in the loss of function mutants with the function of the protein product. Training content (objective, benefit and expected impact) The training contents the project offers are primarily in bacterial, fly and yeast genetic engineering. The molecular characteriza- tion of the gene will require the application standard molecular genetic techniques. The analysis of the pattern of expression of the mRNA and protein in wild type and mutant animals will imply a fair amount of embryological analyses. The creation of new mutants will require the use o different mutangenic techniques as treatment with EMS, mobilization of P-elements,etc. The creation and use of antibodies will lead to the application of cellular biology techniques. The two hybrid system will be used to find molecules interacting with the gene. The expected benefit of the project is a better kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reactor optimisation by membrane enhanced operation' (ROMEO).

assistant: **Concept**

The integration of reaction and downstream processing steps into a single unit is of central importance in order to achieve a new level of process intensification for catalytic driven and eco-friendly reaction systems. This disruptive technology concept has the ability to reduce the total energy consumption of large volume industrial processes by up to 78%. Additionally, emissions can be reduced by up to 90%To achieve this, HOMOGENEOUS catalysts are supported on membranes. Embedding the homogeneous catalysts in thin films of non-volatile ionic liquids (SILP technology) will maintain their catalytic abilities as in the homogeneous phase while the anchoring directly on the membrane ensures a most efficient separation.The new technology concept will be proven by two prominent large volume reaction types: a) Processes with undesired consecutive reactions like hydroformylation and b) Equilibrium driven reactions like water gas shift (WGS) reaction.These processes for bulk chemicals and bio energy applications have been chosen to demonstrate the high impact of the ROMEO technology in an industrial near environment.Nonetheless, it is a core task to also get a detailed understanding of the general processes on a molecular level for the different required functionalities. One achievement will therefore be to provide a modelling “tool-box” that can be applied to any other process in order to check the benefits of the ROMEO technology for a specific reaction in a short time.The ROMEO reactor methodology allows being highly flexible and adapting to both different process and volume requirements. An increase in production volume can then be achieved by a simple numbering up of reactor modules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spatiotemporal coordination of microtubule-organizing centers in two evolutionary distant eukaryotes' (MTOControl) under Horizon Europe.

assistant: **Objectives**

Microtubule-organizing centers (MTOCs) are key eukaryotic structures for microtubule nucleation and organization. Many MTOCs contain centrioles, organelles with two critical functions. i) In mitosis, they localize to the pole of the mitotic spindle aiding its organization. ii) After cell division, centrioles are repurposed as basal bodies at the plasma membrane where they are essential for cilia/flagella formation. Defects in centriole/basal body (CBB) repurposing can have devastating consequences and lead e.g. to infertility in human sperm. CBB functions correlate with subcellular localization, but is the spatiotemporal control required for this organelle to fulfill two distinct functions? How did the ancestral CBB evolve these functions? And why are different MTOCs not present simultaneously in a cell? To tackle these questions, I will first analyze and compare CBB repurposing strategies during the cell cycle of the green alga Chlamydomonas rheinhardtii with those in the complex life cycle of the acellular slime mold Physarum polycephalum, two evolutionary distant eukaryotes. To do so, I will develop and apply a correlative microscopy workflow in which time-lapse imaging of cells is followed by cryo-fixation and expansion microscopy (Cryo-ExM) combined with Stimulated Emission Depletion (STED). Using transient overexpression and laser ablation, I will interfere with spatial and temporal control of CBB repurposing to elucidate the role of subcellular location of this bifunctional organelle. Further, I will study how cells cope with several different MTOCs at a time, likely competing for tubulin. This project will provide a novel, high-end correlative live-cell and super-resolution imaging pipeline, which can be easily adapted for various species and cellular structures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid nanostructured systems for sustainable energy storage' (HYNANOSTORE).

assistant: **Innovation**

Humanity will increasingly need safe, clean and always available energy. Thus, having good energy storage systems will be more and more important in the future. Efficient and sustainable rechargeable batteries are required to power portable electronic devices, new hybrid electric vehicles and to store electricity from renewable sources.The mission of HYNANOSTORE is the development of new environment-friendly systems based on that organic molecules which are used in the chemistry of life for the storage of chemical energy and its transformation in electrical energy. HYNANOSTORE re-thinks the concept of battery’s electrode based on lithium insertion and propose a novel architecture in which the redox properties of bio-molecules such as enzymatic co-factors can take up and release ions reversibly in order to overcome the problems (safety, sustainability and long-term ciclability) associated with the use of conventional Li ion batteries.To achieve this, a nanostructured conductive scaffold with tailored characteristics will provide a framework to immobilize redox active molecules, extended surface area to maximize their loading, a pathway for the charge transport and a diffuse interface for the interaction with the electrolyte. The new bio-inspired engineered system developed after the successful completion of HYNANOSTORE will offer benefits in terms of power and cyclability; an energy density of 500 W h kg-1 and the retention of at least 90% capacity after cycling 800 times are expected with the implementation of these systems.The output of the project HYNANOSTORE will be the introduction of a new concept for lithium ion batteries towards cheap, green and versatile energy storage devices.


**Keywords:** energy storage, nanomaterials, rechargeable batteries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New super-energy efficient non-volatile memory manufacturing – bringing Europe back on the semiconductor track' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project will map out the global market and technical specifications for new non-volatile static random-access memory products (nvSRAM) and systems (system on chip, embedded systems) in a feasibility study, including a business plan for the market introduction. ANV, as a fabless company, will prepare an innovative SONOS-module with 90nm-technology for SOC solutions with extremely low power nv memory cells. This is a ground-breaking solution, merging the advanced but dissimilar technologies ‘Logic’, ‘DRAM’, and ‘FLASH’ in one cost-effective solution. The nvSRAM IP blocks offer unlimited and fast (< 20ns access) read and write operation and a reduced energy demand by factor 10,000 compared to a conventional Flash. No comparable solutions on the market provide such scalable high energy efficiencies, application areas and cost saving opportunities. This will enable the target users to integrate low power nv memory into SOC and dedicated stand-alone solutions at competitive prices. Industrial electronics, medical technology products, measuring/sensor technology and data storage/server technology (computing) are the core markets with a fast growing volume of about $150Mn for nvSRAM products and estimated $15.7 Bn for embedded FLASH.The micro-electronics industry in Europe, comprising research-intensive SME, fabless and producing companies receive competitive SOC solutions for new product innovation in order to step back on the road to success in the semiconductor world. The feasibility study will assess and prioritize technical specifications for process integration at the production line according to customer needs as well as tasks for production robustness of the new NVSM. It will prove the economic viability focusing on market trends and development of a licensing and I