RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Single-molecule analysis of DNA polymerase in vitro and in vivo: a machine in action' to be submitted under Seventh Framework.

assistant: **Abstract**

DNA polymerases are dynamic molecular machines that faithfully copy genetic information during DNA replication and DNA repair. DNA polymerases use the information in a DNA template strand to synthesize a complementary copy by adding nucleotides to the 3 -end of a DNA primer. Extensive  analysis has provided information on the structural organization of polymerases and led to proposals of a general scheme for nucleotide addition. However, there are many unanswered questions; we cannot really claim that we understand how the polymerase machine works in detail and how its function is modulated by its substrates, or by the intracellular environment of cells. One of the main reasons lies in the fact that crystal structures cannot directly capture the dynamics of multi-step processes, since the structures are static snapshots of structural states. Another limitation arises from the difficulty of interpreting biochemical studies of complex mechanisms, because of complications due to ensemble- and time-averaging of the observed signals.We propose to overcome these limitations by studying DNA synthesis by a proofreading DNA polymerase (Pol I) through direct, real-time observation of its movements and interactions at the single-molecule level. We will study mechanisms of fidelity through comparisons involving mutant polymerases, mispaired nucleotides, or partially mispaired DNA, and make comparisons with RNA polymerases. We will also study the conformation and subcellular localisation of Pol I in bacterial cells. Our specific aims are:1. To study conformational transitions of the DNA polymerase I fingers subdomain2. To study translocational dynamics of DNA polymerase I on DNA substrates3. To study the coupling of DNA polymerase I motions during nucleotide addition4. To study conf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Researchers for Humanity 2021' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

"Researchers for Humanity 2021"" will continue the work of the series of European Researchers' Night events organized in Romania since 2007. Pursuing the previous editions goals, this event will focus on creating a strong bond between the public and researchers, by carrying on with presenting the audience the importance of science and research work for humanity's daily life and by making the researchers more approachable for the public in general. Year after year, we keep up with promoting the European dimension of the event and it is only natural to emphasis on the public's awareness, which will flag European Researchers' Night 2021 as one of the most important and awaited events, in terms of science, research and education, as it happened in the past years. This year, during 1 day (or 2 days in some places), the public will have the opportunity to better understand science projects and researchers ideas and motivation by taking part in interactive hands-on sessions, learning by doing, education through play, as well as being encouraged to have interesting talks with the researchers themselves. The event will maintain its traditional logo as a clear connection with the European and national dimension of the event. Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level. Due to the long lasting relationships, the partnerships will be continued with the main actors from mass-media and most of the important players in private research, universities and non-formal education institutions.""


**Keywords:** Science, Researchers, Science fun, Learning, R4H, Caravan,Youngsters, Research, Hands-on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Economic design and construction with light weight aggregate concrete' under Fourth Framework.

assistant: **Concept**

- State of the art report on LWAC- Research reports on different topics (hydration-induced deformations, strength under sustained loading, creep and shrinkage, chloride penetration)- Influence on design codes through participation in Task Group 8.1 Lightweight Aggregate Concrete" of the FIBNote: During the project is was decided to focus more on long-term properties of concrete than on the originally planned in-depth (numerical) studies on moisture transport in LWAC.The objective of this project is to develop a reliable and cost effective design and construction methodology for structural concrete with light weight aggregates ILWA). The project addresses LWA manufactured from geological sources (clay, pumice etc) as well as from waste/secondary materials (fly ash etc). The methodology shall enable the European concrete and construction industry to enhance its capabilities in terms of cost effective and environmentally friendly construction, combining the building of light weight structures with the utilization of secondary aggregate sources.  The research will be innovative in the development/improvement of materials, methods and elements/components that can open for new and un exploited applications. It is precompetitive by aiming to improve international standards and guidelines, and by including in the consortium a broad variety of present and potential competitors within several of the sectors involved, who find it necessary to cooperate in developing a market and establishing a common platform for future exploitation.  The baseline is an international state of the art and extensive national research in which the consortium partners have played a key role. The project will draw on this present knowledge, coordinate, validate and utilize the results in an extended de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Discovery of novel β-lactam analogs oriented to control multidrug-resistant bacteria enabled by Pd-catalyzed C–H activation of aliphatic amines' in the context of a Horizon 2020 call.

assistant: **Objectives**

In Europe, infections caused by multidrug-resistant bacteria lead to more than 25,000 deaths and expenses of billions of euros per year. These numbers dramatically increase when the rest of the world is taken into consideration. Shockingly, the pace of production of new antibiotics to control such microorganisms is stagnating. Therefore, developing new synthetic tools that enable the synthesis of scaffolds with potential antibiotic properties is crucial. Metal catalysed C–H activation represents a versatile tool for building chemical complexity. It mostly relies on directing functional groups to functionalize C–H bonds. Recently, Professor Gaunt at the University of Cambridge has uncovered a new C–H activation mode that enables the conversion of hindered amines into β-lactams. The first aim of this project is to develop this new reactivity mode into a versatile transformation that is able to convert a variety of cyclic and acyclic amines into substituted β-lactam scaffolds. To accomplish this goal, a multi parallel platform based on mass spectrometry, relying either on standard high-throughput procedures or flow chemistry, will be implemented and used to screen a large number of conditions to expand the scope of this new pathway for β-lactams. The flow chemistry system for reaction evaluation will be design in collaboration with Professors Alexei Lapkin (Dept. Chemical Engineering and Biotechnology) and Steve Ley (Chemistry Dept.) from the University of Cambridge. The readily discovered new conditions for C–H activation will then be employed to synthesize a plethora of β-lactams and β-sultam analogs starting from simple secondary amines. Finally, in collaboration with Professor David Spring (Chemistry Dept. University of Cambridge), the bioactivity of the resulting scaf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Earlier detection of metastases and early diagnosis of cancer with antibody derived molecules' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The proposers of this exploratory award will overcome the problems in cancer of detecting monoclonal antibodies in immunoscintiatraphy with recombinant single chain antibodies an attached binding site binding the radioactive isotope Tc 99m. The binding affinity of the single chain fragments will be improved by increase of the affinity by genetic engineering. The posing SMEs will develop these diagnostic molecules as new pharmaceutical tools for IMAGINA. The single chain fragments will have a number of other options for diagnosis therapy of cancer. For example taking the radioactive isotope Rhenium instead of Tc 99m patients could be treated by radiotherapy. The targets of some of the antibodies will be z ratins as well as other tumour specific antigenes which have to be identified during the fee study. Some of the antibodies the partners have choosen have already been tested in F and showed a very specific binding. But the tumour to tissue ratio was too low and the pl cokinetics is too poor for the clinical use of the unmodified antibodies or their fraamen pharmacocinetcs will be improved by the single chain fragments and the affinity t will not be increased by attaching chelators to the protein, which was one of the major problems in t of monoclonal antibodies for immunoscintigraphy The goals of the project will be as follows:single chain fragments of at least 4 different antibodies single chain fragments with Tc 99m binding domain single chain fragments with high affinity binding site by increase of the affinity tumour to tissue ratio of more than 10 to delineate normal tissue from tumour tissue transchelation of Tc 99m lower than 2 %.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CAALA - Computer Aided Architectural Life-cycle Assessment' (CAALA).

assistant: **Innovation**

CAALA is a German GmbH headquartered in Munich. Founded in 2016, the company is run by four managing directors, and supported by seven additional team members (engineers, software developers, architects, marketers) and five mentors. The company’s mission is to supply building planners with the tool needed to achieve energy and GHG emission savings on a large scale and thereby strengthen a sustainable construction industry in Europe. CAALA therefore provides architects and Building Material Manufacturers with a tool to achieve energy and GHG emission savings on a large scale - since it can be used by non-experts at a very early stage of the design process. CAALA is also estimated to be 10x faster than current tools on the market (thanks to our trademark/secret protected methodology called PLCA). Thus, having the biggest impact upon sustainability. Recent developments and the economic turnaround promise a positive outlook for the European construction market for the near future. Since 2014, the gross domestic product of almost all EU states has been growing and renewed increase in construction activity resulting in an annual growth rate of 3% is expected by experts. With €285 billion. The market potential for CAALA in Europe is estimated at €1.5 billion as CAALA acts as a digital building material trader (BMT) by including building material manufacturers (BMM) and increasing their sales. As a first step towards the conception of a market ready product, this Phase I will serve the purpose of elaborating an improved business plan through the implementation of a feasibility study. After the completion of the feasibility study Phase II and Phase III implementation will follow to launch the final product in the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Wasserglass in leather production (in order to minimize tannery wastes)' (WASSERGLASS) targeting Fifth Framework.

assistant: **Abstract**

General: During the project, VAL has established contacts with PQ Corp (Head quarter in USA, European R&D  HQ in Maastricht/ NL. PQ is the world largest producer of silicates and strongly interested in cooperation). In various discussions with PQ, it could be made clear that the type of Wasserglass (ratio Na2O/SiO2) has only very little influence on the penetration results. Much more important is a very slow neutralization, which leads to a uniform silicate  distribution in the cross section of the pelts. This was certified by SEM/ microprobe analysis by VAL, carried out in cooperation with a specialized institute.Work package 1  Process Optimization and Implementation:For chrome  tanned shoe upper leather from bovine hides the procedure has already been developed and semi  technical trials have shown a leather quality comparable with those from commonly produced leather (partners LGR + HEINEN)Chrome and chrome-free automotive leathers (partners VAL + VOGL, supported by BOEHME) have shown some weaknesses in the process reliability, but it seems that with slow neutralization and horsing this problem can be overcome. These partners agreed to continue this development after the project end.Procedures for shoe upper leather from calf skins (SSIP + NOBEL) and for garment leather from sheep skins (SSIP + HAMANA) have been improved remarkable and are in the state of technical implementation. Especially in terms of chrome tannage, 30 % reduction in the chrome tannin offer has already been proofed. Samples of all partners have been presented at the final meeting.Reduction on effluent loading could be verified at all trials and is presented in details in the Final Report. In addition, comparative analysis regarding sludge volumes also indicate decreasing volumes from the com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Breakdown mechanisms and their implication on new test methods for power distribution medium voltage cables systems' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content i 1) Further evaluate the effectiveness of the negative half cycle test in detecting defects in a variety of cables. This would include both defects artificially introduced into lengths of cables and the application of the test to sections of used cables containing known defects introduced in service.I The type of defects which are identified by this method would be found. These would be compared and contrasted with the types of defects found by conventional 50Hz testing. 2) Identify the mechanisms which lead to failures preferentially occuring in the negative half cycle. This would include a review of breakdown mechanisms, and modelling of the behaviour of the insulation material in this regime. 3) Determine to what degree, if any, the negative half cycle test results m retained space charge in the insulation material. and to what extent this influences the subsequent breakdown strength of the cable. Techniques will be developed to measure the space charge introduced in a defect, to support the techniques availalbe for determining space charge generally.4) Investigate the influence of frequency on the breakdown characteristics and introduction of space charge effects in order to determine the optimum frequency of the half negative wave for detecting defects. Initial limited factorial experiments will be carried out. These will provide a macroscopic description of the behaviour which will be refined by modelling. The outputs from the model will then be confirmed experimentally. Training content (objective. benefit and expected impact) The training content of this work is considerable. It is expected that extensive technology transfer will take, place during the research which has many novel aspects and is expected to form the basis of a P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'f-block hydrocarbon interactions: exploration; exploitation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding, controlling, and predicting the subtle interactions that hydrocarbons form with metals is a major challenge in molecular science, and a key technology enabler in areas such as homogeneous catalysis, drug recognition, polymer properties, and metal recovery. For the f-block, it is important due to the urgent need for clean access to critical elements such as neodymium, and the safe handling of nuclear waste. However, technical challenges of paramagnetism, radiotoxicity, and relativistic effects, make quantifying and exploiting f-block hydrocarbon interactions very hard using traditional methods or calculations alone. We have used organometallic systems to study two types of poorly understood hydrocarbon interactions with f-block metal cations: arene binding which is stronger, yet controversial in terms of its electronic demands, and neutral hydrocarbon C-H bonding which is weaker, yet crucially reaction controlling. f-ex sets out a new way to experimentally measure and define these subtle hydrocarbon interactions. It then exploits the stored electrons in the metal-arene motif as a new method to control these powerful Lewis acidic metals for new hydrocarbon C-element bond formation and inert hydrocarbon C-H bond cleavage, with the ultimate aim of viable, low-energy hydrocarbon functionalisations. Uniquely, we will extend our organometallic work to the more difficult transuranic elements, and exploit high pressure solution (and single crystal) work to enhance and interrogate intermolecular C-H binding. The targets of this combined study now offer high scientific impact by demonstrating fundamental bonding insight and ground-breaking structures and reactions.Unprecedented new insight also derives from incorporating new techniques, e.g. high-pressure solution a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neurodevelopmental outcome in offspring conceived by parents at advanced parental age' (NeuroAPA), addressing dissemination and exploitation.

assistant: **Impact**

In current society, a growing number of individuals is affected by mental disorders, thus representing a burden with significant health, social and economic consequences. Notwithstanding, the ethiology of mental disorders is still not fully understood, there is a growing evidence that current trend to delay first childbirth above age of 35 is a factor of risk for the onset of mental disorders (i.e. autism, schizophrenia) in resulting offspring. This “new” reproductive trend, caused by social and economic factors, has already allowed the birth of millions of babies worldwide. In the last decade, epidemiological studies have suggested that children conceived at advanced maternal age are at higher risk of autism spectrum disorders as well as psychotic and/or bipolar disorder and those conceived at advanced paternal age at higher risk of autism and schizophrenia. However, data from population-based investigation are often controversial, due to several confounding factors (i.e. health, socio-economic status, lifestyle), and information from animal studies are still limited. In this context, the assessment of neurological and/or psychiatric health of offspring conceived at advanced parental age (APA) is urgently needed. Moreover, understanding the mechanism(s) behind increased risk of mental affliction (i.e. autism and/or schizophrenia) will contribute to the identification of novel marker for neurologic/psychiatric disorders with a significant impact on basic science, society and health care services.“NeuroAPA” aims to identify structural and functional abnormalities in adult brain which may contribute to the increased risk of psychiatric disorders (i.e. autism, schizophrenia) in offspring conceived by parents at advanced parental age.