RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mobilising the Arts for an Inclusive Digital Transformation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Thirty years ago, the internet, social media and smartphones had not been invented. Yet a generation later, almost every facet of our individual, public and -now- online life are dominated by the fast-pacing digital transformation. Last year we saw the privacy and data of millions of social media users compromised with little to no accountability for those responsible, national elections influenced by users in different states, news outlets struggling to convince readers of facts, and the European Union taking proactive measure to protect the data privacy of its citizens in its first transnational regulatory action. Yet, the digital literacies and capabilities necessary for citizens to thrive in a digital society and act as responsible and effective participants, are unequally distributed across the European cultural, economic and social strata, with the public sphere consequently rapidly dissolving. ARTSFORMATION will respond through research, innovation and applied artistic practice to these societal challenges, by equitably developing the capacity of artists and citizens alike -including those from geographically remote, socio-economically excluded minority, refugee and migrant backgrounds- to respond cohesively in making their communities and groups resilient and adaptive in the 4th Industrial Revolution.


**Keywords:** digital transformation,  artificial intelligence,  future of work,  democracy in crisis,  arts-based methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Decoding interactions between adipose tissue immune cells, metabolic function, and the intestinal microbiome in obesity' (ADIMMUNE), addressing dissemination and exploitation.

assistant: **Impact**

Obesity and its metabolic co-morbidities have given rise to a rapidly expanding ‘metabolic syndrome’ pandemic affectinghundreds of millions of individuals worldwide. The integrative genetic and environmental causes of the obesity pandemicremain elusive. White adipose tissue (WAT)-resident immune cells have recently been highlighted as important factorscontributing to metabolic complications. However, a comprehensive understanding of the regulatory circuits governing theirfunction and the cell type-specific mechanisms by which they contribute to the development of metabolic syndrome islacking. Likewise, the gut microbiome has been suggested as a critical regulator of obesity, but the bacterial species andmetabolites that influence WAT inflammation are entirely unknown.We propose to use our recently developed high-throughput genomic and gnotobiotic tools, integrated with CRISPR-mediated interrogation of gene function, microbial culturomics, and in-vivo metabolic analysis in newly generated mouse models, in order to achieve a new level of molecular understanding of how WAT immune cells integrate environmental cues into their crosstalk with organismal metabolism, and to explore the microbial contributions to the molecular etiology of WAT inflammation in the pathogenesis of diet-induced obesity. Specifically, we aim to (a) decipher the global regulatory landscape and interaction networks of WAT hematopoietic cells at the single-cell level, (b) identify new mediators of WAT immune cell contributions to metabolic homeostasis, and (c) decode how host-microbiome communication shapes the development of WAT inflammation and obesity.Unraveling the principles of WAT immune cell regulation and their amenability to change by host-microbiota interactionsmay lead to a conceptual leap fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In-situ replacement of fluoropolymer coating for production plant rollers' in the context of a Fourth Framework call.

assistant: **Objectives**

A new polymer for sprayed fluoropolymers in-situ.A laser heating system for heating of rollers.A powder deliver system for the application of the polymer.A prototype integrated system for carrying out the delivery and heating in-situ.Objectives and content Objectives and content A large number of varied industrial production processes currently rely on process rollers coated with Fluoropolymer to provide a non-stick, corrosion resistant surface. Unfortunately the lifetime of these Fluoropolymer coated rollers in the paper, textile, paper and film converting industries is very short with the Fluoropolymer coating failing within 1 year. Failure of the Fluoropolymer coating results in the closure of the plant and removal of the rollers which then have to be sent to a specialist facility for re-coating. The removal of these huge rollers is a complex and costly process and the regular requirement to do this at least once a year results in significant plant down time and other associated costs in the dismantling, removal and transportation of the rollers. The aim of the project is to develop methodologies to replace the Fluoropolymer roller coating in-situ. This will alleviate the need to remove the rollers from the plant or their position in the plant and will hence vastly reduce the downtime of the plant and bring economic and safety benefits In order to achieve the overall goal of coating Fluoropolymer rollers in-situ the project has two distinct research goals as follows:  To develop a modified Fluoropolymer with an optimised melt/set temperature.  To develop an in-situ heating system based on laser technology to achieve the setting of the above Fluoropolymer on the rollers Together these two innovative technical developments will provide the solution to the problem of ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable control of Onchocerciasis today and tomorrow' (SCOOTT), addressing dissemination and exploitation.

assistant: **Impact**

The purpose of this project is to improve sustainable control of onchocerciasis (river blindness) through refinement of existing chemotherapeutic regimes and identification of new targets and approaches for integrated control that will combine chemotherapy with vaccination.The demand for these studies comes from:1, the need to control re-emergence of onchocerciasis in regions where transmission had been interrupted;2, indications consistent with the emergence of ivermectin resistance; and3, concern about adverse side reactions following ivermectin treatment in loiasis endemic areas.There are three primary objectives:Workpackage 1, Refinement of existing chemotherapeutic regimes by use of doxycycline to complement ivermectin treatment and further screening of existing drugs;Workpackage 2, Assessment of immunological sequelae of ivermectin intervention and their implications for improved control strategies; andWorkpackage 3, identification of new targets, including vaccine candidates and approaches for integrated control.As doxycycline is already licensed for human use, combination therapy with ivermectin for selected indications (not mass treatment) will deliver short term impact while providing a framework for the longer term vision of integrated chemotherapy-vaccine control of onchocerciasis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Support towards the Europe PMC initiative-Contribution for 2014-2016' (ERC-EuropePMC-1-2014).

assistant: **Innovation**

The proposed action will provide continued support to the European Research Council (ERC) in the implementation of its Open Access strategy for projects funded in the Life Sciences domain. It follows on from the project ""Support towards the Europe PMC initiative-Contribution for 2013""(ERC-EuropePMC-SUP-2013) which has allowed the ERC to offer the benefits of Europe PMC to its funded researchers for the first time in 2013. The ERC Open Access strategy, and how the present project will assist the ERC in its implementation, is explained below""


**Keywords:** Open Access,  Europe PMC, repository, OA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fully Adaptive Simulation Tool for Kinetic Theory' to be submitted under Horizon 2020.

assistant: **Abstract**

Kinetic models are omnipresent in a wide range of scientific and engineering applications. They are derived from the evolution of a particle distribution in position-velocity phase space, and appear, for instance, in the modeling of fusion energy reactors and atmospheric reentry of spacecraft, where classical fluid equations are inaccurate. Further technological progress of these applications requires significant advances in modeling and simulation of kinetic models. The underlying kinetic equations pose severe simulation challenges, due to their inherent high-dimensionality and the presence of a wide range of time scales.The increased dimensionality in velocity directions can be addressed by an extended set of fluid quantities via moment models or the maximum entropy method. To deal with the stiffness of the equations, asymptotic-preserving time discretization methods need to be used. Since both the stiffness and the accuracy of a kinetic model depend on space and time, the design of numerical methods incorporating fully integrated space-time adaptivity is crucial to allow these methods to be efficiently used in real-world applications.In this action, the applicant will integrate his expertise on moment models with the experience on projective integration schemes available at the host institution, and extend their applicability towards a wide range of kinetic models hereby achieving the following objectives:- Develop fully space-time adaptive numerical scheme for kinetic models- Implement software for space-time adaptive solution of kinetic models- Compute numerical solutions for real-world applicationsThe results of FASTKiT will constitute a major step forward in the adaptive simulation of kinetic models. FASTKiT will contribute to the development of technologies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of dental resin-modified cements suitable as restorative in stress bearing areas based on identifications of materials properties' (1994-1998).

assistant: **Innovation**

In the last years, a public debate has arisen on the health hazard of amalgam as a tooth filling. In turn, the demand for substitutes has increased, and new dental composites are being developed. However, during the polymerisation process, these materials are shrinking, which may lead to crack growth. The consequence is a bad adhesion to the tooth, so that the filling cannot accomplish its purpose. Up to now, the suitability of new filling materials has to be examined in expensive and extensive clinical tests. The aim of this research project is to develop procedures to evaluate the suitability at an earlier stage, so that the immense expenses for clinical tests can be decreased greatly. For this purpose, the material behaviour during the polymerisation process has to be modelled, so that simulative studies can be performed. Simultaneously, sophisticated experimental investigations have to be performed, in order to determine the characteristic material parameters correctly. In this project improved glass polyalkenoate cements for the application in stress bearing areas will be developed. The specific RTD goals are the following: - investigation of the particle size and distribution (filler loading) of the glass volume fraction of glass polyalkenoate cements, with the aid of computer modelling techniques and laboratory research, for a better knowledge of the optimal composition of the material, - optimisation of the composition of the liquid, by determining the optimal ratio between acidbase reaction and resin- addition reaction, in order to design an improved polymer matrix, - modelling and characterisation of the polymerisation process to achieve a better understanding of the phenomena, - a proper characterisation of the material behaviour based on a suitable modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Continual learning and memory for sounds in rat'.

assistant: **Objectives**

How much can we remember and for how long? Decades of key advances in our understanding of synaptic plasticity resulted in a puzzle. On the one hand, memories can be highly stable and organisms are capable of adding new memories without destroying old ones. On the other hand, data and models support neither stability nor lifelong (‘continual’) learning. Many experiments suggest that responses of neuronal populations slowly but inexorably drift (“representational drift”), while synapses spontaneously turnover. At the same time, models predict that memory traces of new experiences tend to interfere destructively with old traces. Here, I will study auditory continual learning in the behaving rat. I will develop a novel behavioral paradigm that will train rats to recognize two new sounds every few days, memorizing up to 100 sounds over 3-4 months of continuous training, and check the stability of memory during that time. My lab will apply state-of-the-art recording techniques in order to document the neural activity during memory acquisition and between training sessions while the rats sleep and consolidate newly acquired memories. I will repeat these studies in a rat model for Alzheimer’s disease, which expresses early memory deficits. These results will be compared with predictions of models for memory in the auditory cortex. At one end, I will test the predictions of a model, based on recently published results, that posits the existence of a few neurons that carry the memory of each learned sound by intrinsic bursting. At the opposite end, I will test predictions of models in which memory resides in the coordinated activity of large, distributed ensembles of neurons. Overall, this project will address the deep puzzles of memory when memory load is high, a regime that ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'From prosody to music: an fMRI study on emotional processing in autism' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The purpose of this study is to investigate emotional processing during auditory stimuli presentation, in subjects with Autism Spectrum Disorder (ASD) and healthy subjects. In particular, the study will apply functional imaging to understand neurobiological correlates of affective prosody and music perception. Studies have so far thoroughly explored the deficit of individuals with ASD in identifying emotions in visual stimuli (facial expressions), but little is known about their ability to perceive emotions conveyed by auditory stimuli such as affective prosody and music. Affective prosody is the melodic and rhythmic component of speech that listeners use to gain insight into a speaker's emotive disposition. While there is limited information about the ability of individuals with ASD to identify emotions in affective prosody, there is some evidence of impairment in this ability. Music has been found to be capable of evoking and conveying strong and consistent positive and negative emotions.In a few experimental studies, subjects with ASD have been found to be able to properly identify the positive or negative emotional valence of music stimuli. Currently very few functional imaging studies have investigated affective prosody in subjects with ASD, suggesting different patterns of brain activation, and no functional imaging studies have explored emotional processing of music in these subjects. Evidence from clinical studies suggests impairments in the ability to understand emotion conveyed by prosodic cues and preserved ability to properly identify the emotional valence of music stimuli. By comparing subjects with ASD to healthy subjects we will identify impaired and preserved brain circuitries involved in emotion processing of voice and music, highlighting implications f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New Frontiers in Cellular Reprogramming: Exploiting Cellular Plasticity' (CELLPLASTICITY).

assistant: **Innovation**

Our research group has worked over the years at the interface between cancer and ageing, with a strong emphasis on mouse models. More recently, we became interested in cellular reprogramming because we hypothesized that understanding cellular plasticity could yield new insights into cancer and ageing. Indeed, during the previous ERC Advanced Grant, we made relevant contributions to the fields of cellular reprogramming (Nature 2013), cellular senescence (Cell 2013), cancer (Cancer Cell 2012), and ageing (Cell Metabolism 2012). Now, we take advantage of our diverse background and integrate the above processes. Our unifying hypothesis is that cellular plasticity lies at the basis of tissue regeneration (“adaptive cellular plasticity”), as well as at the origin of cancer (“maladaptive gain of cellular plasticity”) and ageing (“maladaptive loss of cellular plasticity”). A key experimental system will be our “reprogrammable mice” (with inducible expression of the four Yamanaka factors), which we regard as a tool to induce cellular plasticity in vivo. The project is divided as follows: Objective #1 – Cellular plasticity and cancer: role of tumour suppressors in in vivo de-differentiation and reprogramming / impact of transient de-differentiation on tumour initiation / lineage tracing of Oct4 to determine whether a transient pluripotent-state occurs during cancer. Objective #2 – Cellular plasticity in tissue regeneration and ageing: impact of transient de-differentiation on tissue regeneration / contribution of the damage-induced microenvironment to tissue regeneration / impact of transient de-differentiation on ageing. Objective #3: New frontiers in cellular plasticity: chemical manipulation of cellular plasticity in vivo / new states of pluripotency / characterization of in v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Finding noncoding cancer drivers' (NONCODRIVERS) under Horizon 2020.

assistant: **Objectives**

Finding the mutations, genes and pathways directly involved in cancer is of paramount importance to understand the mechanisms of tumour development and devise therapeutic strategies to overcome the disease. Due to their role in cancer development and maintenance, the proteins encoded by cancer genes are candidate therapeutic targets. Indeed, in recent years we have witnessed the development of successful cancer-targeting therapies to counteract the effect of driver mutations. Although the coding part of the human genome has now largely been explored in the search for cancer driver mutations in most frequent cancer types, the extent of involvement of noncoding mutations in cancer development remains a mystery. The main challenges faced are: 1) the functional role of most noncoding regions is unknown, and 2) tumours often have thousands of somatic mutations, so that distinguishing cancer driver mutations from bystanders is like finding the proverbial needle in a haystack.  To overcome these two challenges I propose to analyse the pattern of somatic mutations across thousands of tumours in noncoding regions to identify signals of positive selection. These signals are an indication that mutations in the region have been positively selected during tumour evolution and are thus directly involved in the tumour phenotype. The large scale analysis proposed here will allow us to create a catalogue of noncoding elements involved in different types of cancer upon mutations. We will study in detail a selected set of driver elements to uncover their specific function and role in the tumourigenic process. Furthermore, we will explore possibilities of counteracting their driver effect with targeted drugs. The results of this project may boost our understanding of the biological role of