RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hyperpolarized Surface-enhanced Liquid-State Spectroscopy' to be submitted under Horizon Europe.

assistant: **Abstract**

Across science, medicine, and industry, nuclear magnetic resonance (NMR) is a key technique with the unique capacity to provide atomistically detailed molecular models. Its primary drawback, however, lies in its low sensitivity, limiting its ability to address critical scientific questions. A potential answer is hyperpolarization via dissolution dynamic nuclear polarization (dDNP), which can amplify NMR sensitivity 10,000-fold. Despite this promise, dDNP remains a niche method constrained to a narrow range of substrates. Most experiments and nearly all biomolecules remain beyond dDNP’s reach; thus, a plethora of opportunities are missed.HypSurf aims to exploit the full potential of dDNP by rendering it applicable to all solution-state biomolecular systems – for experiments across the entire biomolecular NMR toolbox. This transformative goal comprises three primary objectives:1) Universal compatibility will be achieved by building Autonomous Interface Devices (AID): versatile and adaptable instrumentation to seamlessly update any NMR spectrometer with dDNP capabilities.2) Maximized Substrate Scope will be achieved with artificial intelligence-driven Liquid-state Surface-ENhanced Spectroscopy (LiSENS): a resolution-enhanced method for dDNP-powered studies that uses simply water as a transporter of signal intensity. Thus, the requirement for the 10,000-fold signal boost by dDNP is narrowed down to mere solubility. 3) Confirmation of the versatility and prowess of AID and LiSENS will be achieved by providing super-resolution data at maximized sensitivity for an extensive set of cutting-edge applications in biomimetic materials, structural biology, and chemistry.HypSurf has the potential to set a new standard for NMR by boosting both resolution and sensitivity by orders of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Revolutionizing AI in drug discovery via innovative molecular representation paradigms' (ReMINDER).

assistant: **Concept**

Artificial intelligence (AI) in the form of deep learning is driving unprecedented progress in numerous fields, e.g., for protein structure prediction and organic reaction planning. In drug discovery and chemical biology, such progress is an “evolution” rather than a revolution: several tasks still await to be solved by AI, e.g., accurate structure-activity and activity-cliff prediction, and design of structurally innovative chemical matter. Increasingly complex deep learning approaches are leading to progressively smaller gains in model capabilities, calling for a revolution in AI for drug discovery. The springboard for this project is a striking observation: while novel deep learning algorithms are in continuous development, the input ‘raw’ molecular representations they rely on (e.g., SMILES strings and molecular graphs) have not considerably changed in the last four decades – limiting the amount and quality of chemical information learnable by AI. The potential of capturing more sophisticated chemical information better into a new ‘molecular language’ is still untapped and bears promise to revolutionize molecular AI. ReMINDER will break with traditional approaches and shift the object of study from increasingly complex algorithms to novel molecular representation paradigms for AI. ReMINDER will be an agent of change in the molecular AI landscape, by developing a new representation framework at the interface between method development and experimental validation. ReMINDER will disrupt the potential of AI to (a) navigate complex structure-activity landscapes, (b) design innovative bioactive molecules from scratch, (c) leverage binding pocket information for molecule discovery. By transforming the chemical information captured for AI, we open opportunities to develop m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Variational coarse-graining of lattice energies for crystal defects: Applications to partial dislocations and stacking faults' under Horizon Europe.

assistant: **Concept**

Defects are omnipresent in crystalline materials and the understanding of their emergence and interaction is essential for the prediction of the macroscopic material behaviour. Thus, there is a huge interest to pass in a rigorous mathematical way from atomistic models for crystal defects to macroscopic models, e.g., for crystal plasticity. From a variational viewpoint this can be addressed by deriving effective limiting energies from lattice energies when the lattice spacing vanishes. A powerful method to carry out such a variational coarse-graining procedure is Gamma-convergence. In this framework we address here the variational coarse graining of lattice energies which capture the formation and interaction of defects of different dimension, namely partial dislocations and stacking faults. The splitting of dislocations into partial dislocations resulting in a stacking fault is a typical phenomenon of closed-packed crystalline structures. Thus, on the one hand we aim at proposing and analysing a suitable discrete model for partial dislocations and stacking faults in HCP, on the other hand we will embed this result into a broader context by investigating in a general framework the emergence of fractional vortices and string defects in XY-model type energies. Eventually, we will characterise geometric properties of minimisers for the coarse-grained energies.


**Keywords:** Calculus of Variations, Gamma-convergence, discrete-to-continuum variational analysis, dislocation models, vortex  models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SOurce Drain Architecture for Advanced MOS technology' in the context of a Fifth Framework call.

assistant: **Objectives**

The design, optimisation and fabrication of Accumulated Low Schottky Barrier MOSFETs on SOI is proposed in order to solve critical problems associated to the source/drain architecture and more specifically due to the specific contact resistance at the silicide/silicon interface. A complete validation of the ALSB SOI technology is proposed to move from a laboratory concept to an industrially attractive solution that meets requirements of the ITRS roadmap up to the 35 nm technology node. The design, optimisation and fabrication of Accumulated Low Schottky Barrier MOSFETs on SOI is proposed in order to solve critical problems associated to the source/drain architecture and more specifically due to the specific contact resistance at the silicide/silicon interface. A complete validation of the ALSB SOI technology is proposed to move from a laboratory concept to an industrially attractive solution that meets requirements of the ITRS roadmap up to the 35 nm technology node.OBJECTIVESThe design, optimisation and fabrication of Accumulated Low Schottky Barrier MOSFETs on SOI is proposed in order to solve critical problems associated to the source/drain architecture and more specifically due to the specific contact resistance at the silicide/silicon interface. A complete validation of the ALSB SOI technology will be performed in order to move from a laboratory concept to an industrially attractive solution that meets requirements of the ITRS roadmap up to the 35 nm technology node. The objectives include the demonstration of improved performances of ALSB SOI MOSFETs over conventional architectures: immunity to short channel effects, suppressed sensitivity to dopant fluctuation, used of Schottky source/drain (S/D) contacts to suppress issues associated with tight control of S/D do
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterization of defence genes and proteins active against pathogens in strawberry', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The European strawberry production is of increasing importance, and causes high environment impact due to the high chemical application generally requested. Among the most severe pathogens are species of Collecotrichum and Phytophthora. For both fungi various strains with different degree of virulence and a wide range of susceptibility among varieties exists. Studies on the factors involved in these interactions are useful for the detenction and isolation, through DNA-recombinant techniques, of specific genes involved in defense mechanisms. Using in vivo and in vitro (callus and cell suspension) strawberry varieties, characterised by different susceptibility to the two pathogens, the expression of defence genes induced by specific elicitors (host-cell wall fragments and a toxic lOkD protein purified from P. cactorum culture filtrate), will be analysed. Active proteins will be identified and studied using extracellular extract from resistant cultivar (EER). Genes encoding possible active proteins from EER will be also studied. Recently, the autimicrobial activity conferred by a number of gene constructs has been demonstrated in several species. They are now available for exploitation in fruit crops. Methods for strawberry transformation have been described. Regeneration and genetic transformation protocols in the susceptible strawberry varieties, adapted to the Italian cultivation areas, will be developed and used for the introduction of genes encoding active proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Bone marrow (BM) fibrosis is the continuous replacement of blood forming cells in the bone marrow by scar tissue, ultimately leading to failure of the body to produce blood cells. Primary myelofibrosis (PMF), an incurable blood cancer, is the prototypic example of the step-wise development of BM fibrosis. The specific mechanisms that cause BM fibrosis are not understood, in particular as the cells driving fibrosis have remained obscure.My recent findings demonstrate that Gli1+ cells are fibrosis-driving cells in PMF, that their frequency correlates with fibrosis severity in patients, and that their ablation ameliorates BM fibrosis. These results indicate that Gli1+ cells are the primary effector cells in BM fibrosis and that they represent a highly attractive therapeutic target. This puts me in a unique position to vastly expand our knowledge of the BM fibrosis pathogenesis, improve diagnostics, and discover new therapeutic strategies for this fatal disease. I will do this by: 1) dissecting the molecular and cellular mechanisms of the fibrotic transformation, 2) defining the stepwise disease evolution by genetic fate tracing and analysis of the previously unknown critical effector cells of BM fibrosis , 3) understanding early forms of BM fibrosis for improved diagnostics in patients, all with the ultimate aim to identify novel therapeutic targets to directly block the cellular and molecular changes occuring in BM fibrosis. I will apply state-of-the-art techniques, including genetic fate tracing experiments, conditional genetic knockout mouse models, tissue engineering of the bone marrow niche and in vivo and in vitro CRISPR/Cas9 gene editing, to unravel the complex molecular and cellular interaction between fibrosis-causing cells and the malignant hematopoietic cells. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Triple hybride concentrating pv system fot the co-generation of electricity, heat and cooling power' to be submitted under Fifth Framework.

assistant: **Abstract**

This proposal deals with the development of an industrial prototype of a concentrator type PV system of 3.0 KWp (PV system PROTEAS), which will be able to produce 6000 kWH electricity per year for average Greek solar conditions together with hot water of 55-70oC equivalent to twelve conventional 240 lit hot water solar collectors. Additionally, the system will be able to produce chilled water enough for four 12000 BTU A/C units using the produced hot water in order to produce chilled water in collaboration with a silica-gel absorption heat pump of 15 KW cooling capacity in order to prove the idea of a PV Energy Independent House.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-sectoral approaches to Innovative Skills Training for Renewable energy And sociaL acceptance' to be submitted under Horizon 2020.

assistant: **Abstract**

Europe is at the beginning of a major transition to a low carbon economy and is experiencing substantial growth in  the expansion of renewable energy generating capacity. However, parallel to this technological investment, many Member States are witnessing increasing levels of local opposition to individual projects, particularly for wind energy, which is now the cheapest form of energy generation. This has a range of consequences including increased deployment costs/delays, increased regulatory demands, reduced market support and highlights a major social challenge for the energy transition. In response to this, MISTRAL aims to nurture a new generation of researchers who can effectively evaluate the complexity of social acceptance issues facing the deployment of renewable energy infrastructure and propose innovative solutions in a variety of research, government and business contexts. It will do this by fostering a vibrant inter-disciplinary environment to change the way we understand and respond to declining social acceptance of renewable energy infrastructure and engage a wider range of inter-sectoral stakeholders to develop innovative solutions. MISTRAL will also provide an innovative training environment where young researchers can develop advanced skills in research and transferable skills, benefit form a range of diverse secondment experiences and debate current issues with some of the world leading researchers in the field, in order to develop advanced capacities for progressing Europe’s energy transition.


**Keywords:** Renewable energy,  energy transition,  social acceptance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Digital Twin for Europe'.

assistant: **Objectives**

The current international situation makes the process of energy transition more critical for Europe than ever before.  It is a key requirement to increase the penetration of renewables while aiming at making the infrastructure more resilient and cost-effective. In this context, digital twins (DT) build a key asset to facilitate all aspects of business and operational coordination for system operators and market parties. It is of fundamental importance to now start a process of agreement at European level so not to develop isolated instances but a federated ecosystem of DT solutions. Each operator should be able to make its own implementation decisions while preserving and supporting interoperability and exchange with the remaining ecosystem. Exactly this is the vision of the TwinEU consortium: enabling new technologies to foster an advanced concept of DT while determining the conditions for interoperability, data and model exchanges through standard interfaces and open APIs to external actors. The envisioned DT will build the kernel of European data exchange supported by interfaces to the Energy Data Space under development. Advanced modeling supported by AI tools and able to exploit High Performance Computing infrastructure will deliver an unprecedented capability to observe, test and activate a pan-European digital replica of the European energy infrastructure.In this process, reaching consensus is crucial: the consortium therefore gathers an unprecedented number of actors committed to achieving this common goal. The concepts developed by TwinEU span over 15 different European countries with a continuous coverage of the continental map. Demos will encompass key players at every level from transmission to distribution and market operators, while also testing the coordi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Proving Agency in Mathematical Practice: Practical, Social, and Mental Aspects', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Mathematical reasoning is essential to the development of mathematical and scientific knowledge, and is a crucial skill in our science- and technology-based European societies. Yet, despite the revolutionary advances in formal logic of the past century, the nature of reasoning and proofs in ordinary mathematical practice remains unclear.The ProvingAgency project aims to move forwards on this general question by shifting the focus from mathematical proofs themselves to the activity of proving that gives rise to them. The approach to be developed proposes to structure the inquiry around the different dimensions of proving agency—the capacities of proving agents necessary to the realization of the activity of proving. The ProvingAgency project will implement this approach concretely, within a restricted perimeter, in order to investigate three central aspects of proving agency: practical, social, and mental.Practical aspects are concerned with the practical knowledge required by mathematical agents to prove theorems. One key element of such practical knowledge is the capacity to apply, adapt, and extend mathematical methods. We will develop here an epistemological model of mathematical methods which will be informed by detailed and representative case studies.Social aspects are concerned with the issues that arise when several mathematical agents are proving a theorem together. We will articulate here an account of the shared agency involved in the shared activity of proving together, which will be informed by a sociological study to be conducted on a group of mathematicians at the ETH mathematics department.Mental aspects are concerned with the mental dimension of the activity of proving. We will aim here to provide a conception of proving as a mental activity that does j
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Impact of CAP Reform on the Employment Levels in Rural Areas' (CARERA), addressing dissemination and exploitation.

assistant: **Impact**

The proposed project will provide EU policy makers with information, data, indicators, quantitative instruments as well as empirical expertise (synthetic reports, briefing notes, etc.) on the analysis of structural and employment effects of CAP reform and rural development measures. Specifically, the purpose is to offer detailed information (datasets, economic transactions), to provide an objective assessment on key features of rural areas (employment and income levels) and to deliver tools for simulating the effects of changes on both the CAP and the rural development schemes. This is achieved by combining discrete scientific methodologies in selected EU rural regions to build up an integrate framework of analysis. The expected outputs include: (a) a critical review of CAP reform and its effects on employment in rural regions; (b) a detailed review of instruments available of assessment of CAP reform; (c) an original modeling tool to simulate the impact of CAP reform on farm incomes, crop mix and employment changes; (d) a set of detailed hybrid input-output tables that describe the economic structure of selected rural areas around the EU to cast the overall changes in employment; (e) an analysis of the effects of CAP reform on farmer's economic performance; (f) an assessment of the recent CAP reform from the rural stakeholders point of view; (g) a set of recommendations to Commission regarding probable initiatives to be taken to stimulate employment in future CAP reforms.