RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Real-time characterisation of neuropeptide binding to a membrane receptor involved in pain and ischemic stroke'.

assistant: **Objectives**

Under physiological conditions, localized acidification of brain tissue serves as neuronal signal that get synaptically transduced via acid-sensing ion channels (ASIC1a). Local acidosis has, however, also been linked to some of the most prevalent neurological disorders such as chronic pain, ischemic stroke and psychiatric diseases. ASIC1a has thus emerged as drug target with great potential, but no drugs are currently available that specifically target the channels under pathological conditions. A few known neuropeptides modulate ASIC1a and could thus serve as scaffolds for a new generation of ASIC1a-selective drugs to, for example, treat pain without the typical downsides of opioids. Advances have, however, been hampered by the limited understanding of detailed protein-peptide interactions. Thus, the aim of the proposed project is to directly characterize the binding of the neuropeptide Big Dynorphin to ASIC1a in real time. Here, I will use a unique in-house developed high-sensitivity fluorescence patch-clamp electrophysiology setup and establish a protocol for a FRET-based ligand-binding assay. Together with site-directed mutagenesis, this approach will be able to identify state-dependent binding sites and key interactions, and allow direct analysis of binding affinity and kinetics under pathological conditions; all in intact membranes and with unprecedented (microsecond) temporal resolution. This information will aid future design of ASIC inhibitors with the potential to treat chronic pain and ischemia. The technology developed for this work will also enable ligand-binding studies of other membrane proteins in living cells and with high temporal resolution and will thus be of great potential value for a broad field. The project will expand my existing electrophysiolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of new tumor specific antigens recognized by autologous t lymphocytes' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of the first part of the project is to obtain CTL clones specif for autologous human head and neck carcinoma. Thus tumor cell lines, transfected with the costimulatory molecule B7.1 and treated with IFN-* to augment their immunogenicity, will be used to stimulate autologous blood lymphocytes in the presence of different cytokines. A genetic approach will then be followed to isolate the gene encoding the antigen recognized by the CTL.  In the second part, we will try to identify antigenic peptides that are derived from proteins which are known to be selectively expressed in tumors. Peptides that are deduced from the gene sequence will be chosen on the basis of their ability to bind to a given HLA molecule. Dendritic cells pulsed with the best binding peptides will then be used to stimulate 'naive' T lymphocytes from normal individuals in order to generate CTL that recognize a defined peptide-MHC complex.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Exploring time-dependent memory effects in matter with viscoelastic snap-through of strips.'.

assistant: **Objectives**

Memory is crucial in living organisms and computers, but is also a hallmark of complex materials such as crumpled paper, glasses or sheared foams. Memory manifests itself in a stunning variety, and is central both in fundamental research and for applications (ageing, adaptive matter, programmable matter). A new picture based on novel theoretical concepts, related to the pathways of transitions between metastable states recently appeared, and lead to a flurry of activity. But so far, this work focused mostly on quasistatic memory effects, where the duration of the input does not matter. Yet, time-dependent memory effects are encountered in many complex systems, and their microscopic origin is often unclear. I therefore propose to study time-dependent memory and pathways in a model mechanical system, explicitly tailored to exhibit time-dependent memory, while allowing direct observations and manipulations. Specifically, I will use viscoelastic thin strips that can toggle via a snap-through instability between two states as a basic building block to create systems with emergent time-dependent memory. This project provides the key to experimentally probe and reveal the mechanisms of time-dependent memory in matter, as well as to design and create systems with complex programmable pathways. I divide my project in three work packages:WP1. First, I will study the snapping of viscoelastic strips, that will constitute the basic elements of this model system.WP2. Next, I will assemble several of these strips to monitor the emergence of time-dependent memory effects and study both theirglobal aspects and pathways of transitions.WP3.Finally, I will aim to control time-dependent memory and design complex systems with predefined pathways.Leveraging the versatility and experimental ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Primavera: immunobiotics for treating early stage Age-related Macular Degeneration (AMD)'.

assistant: **Innovation**

Age-related Macular Degeneration (AMD) is a chronic, progressive, sight-threatening disease, caused by the damage of the macula, the small, central area of the retina. People with AMD have difficulty seeing colours, details and later, to read, to drive and to work. The disease causes significant social, medical, and economic burden. Its prevalence (hidden in early stage) is estimated more 8-10% in industrialized countries (EU, USA) for people over 40 years. However, neither screening method is proposed for the early detection of AMD nor its effective treatment has been approved yet. The multivitamin products, found on the market today, have provenly low efficiency to supress early stage AMD, and rather expensive compared to their low-effectiveness. The objective of primavera project is the commercialisation of a new medical food for treatment of AMD. Our new and unique formula, Primavera, is based on immunobiotic compounds, prepared by our innovative technology, and metabolic booster compounds. The new and unique formula will expectedly have benefits on both visual functions and retinal alterations in early AMD. The success of the project will promote the growth of our company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Ermes'.

assistant: **Concept**

We propose an interdisciplinary EuroConference focussed on two main aspects of Seismology, namely, the mechanics of the faulting process of earthquakes, and the structure of the Earth. For many years scientists in separate fields have been working on these problems from different points of view, namely, theoretical, observational, and laboratory experimental ones. At the beginning of the new millennium, it is a propitious time to bring together all these scientists from many countries to review the state-of-the-art at the cutting edge of research in this area and to consider future lines of development. Scientists from as varied subject areas as fracture mechanics, mathematics, seismology; earthquake engineering as well as from industry will be invited to participate. In addition to the list of distinguished core group of speakers, wide participation of younger scientists and their interaction with more established researchers would be a key feature of this conference.The aim is a comprehensive examination from theoretical, observational and laboratory view points of where the subject has been, where it is today, and where it is going (i.e. some review papers, some state-of-the-art papers and some discussions on what are the unsolved problems and what can we do to solve them). The conference will be divided into five sessions: - From laboratory experiments to earthquake dynamics; - Generation of seismic waves and earthquake source; - Deep focus earthquakes; - Earth structure and seismic wave modelling; - Earthquake damage and prediction of strong ground motion. The major part of the meeting will be devoted to the subject of earthquakes and related problems, but since the waves from the earthquake travel through the Earth, the Earth structure must also be considered and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modelling Of Whole-brain Slow oscillatory dynamics in physiology and pathology' under Horizon 2020.

assistant: **Concept**

The brain is a complex system whose function relies on a dynamic information exchange between trillions of neural connections organised hierarchically: local neuronal circuits are interconnected to form large-scale functional networks spanning several brain areas. Neural oscillations are the result of this multilevel interaction and regulate vital processes, from sleep to attention. Neurophysiological techniques, such as electrophysiological recordings or brain imaging, can only investigate separately the micro- and macro-circuits that, together, generate global activity patterns. To date, despite significant recent technical advancements, the causal roles between local and global brain activity, and between global dynamics and overall brain function, remain largely unknown. In this context, complementary computational approaches can dramatically improve the understanding of the multilevel functional organization of the brain. This project aims to develop the first model of whole-brain slow oscillations based on the integration of multi-scale neural activity. Slow neural oscillations (<1Hz) regulate key functions such as synaptic plasticity, memory consolidation and sensory processing. Moreover, abnormalities in this brain rhythm have been linked to the pathogenesis of autistic spectrum disorders. The novelty of my model lays in three aspects. It will include pyramidal neurons, parvalbumin interneurons and somatostatin interneurons, following on the experimental results defining their differential roles in regulating slow waves; it will be based on the integration of multi-scale experimental data acquired in-house (local field potential recordings and fMRI); it will be used to model the slow dynamics alterations occurring in genetically defined autistic-like disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Universal Acoustic Digital Light Processing 3D Printing'.

assistant: **Objectives**

3D printing, or additive manufacturing, has the potential to drastically transform fields such as architecture, aviation, sportswear, robotics, biomedical devices, implants, and tissue engineering. There is an increasing demand for 3D printing of reinforced composites and biological architectures. The 3D printing of composites is technically challenging due to the need to controllably orient and print microparticles. Commonly used 3D printing technologies achieve customizable prototypes using only a single material, and to date, few printers permit the incorporation of microparticles and living cells. Consequently, current methods allow only limited customization of the mechanical properties of printed objects. Acoustics permit microparticles to be manipulated noninvasively. In this proposal, UniADLP, we will develop a novel acoustic-based 3D printer with which microparticles can be aligned and selectively polymerized to develop a user-defined 3D printed object. We will assimilate homogeneous and heterogeneous microparticles while dynamically orienting them during the printing. This proposal will open up a new and exciting area in the field of additive manufacturing, using ultrasound to print reinforced architectures.


**Keywords:** Acoustics, Ultrasound, Microparticle manipulation, 3D printing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanoparticles-based 2D thermal bioimaging technologies' under Horizon 2020.

assistant: **Concept**

Temperature measurements are crucial in countless technological developments, accounting for 80% of the sensor market throughout the world. The pitfalls of temperature readouts at the biomedical battleground are mostly represented by the currently achievable spatial resolution. To address key issues, such as intracellular temperature fluctuations and in vivo thermal transients, a technique able to go clearly below 1 μm is highly and urgently needed, as the traditional contact-based sensors and near infrared thermometers are not suitable for measurements at that tight spatial range. To overcome these limitations requires a non-contact thermometry approach granted with sub-micrometer resolution, also providing real-time high relative thermal sensitivity values.The goal of NanoTBTech is to develop a 2-D thermal bioimaging technology featuring sub-microscale resolution, based on nanothermometers and heater-thermometer nanostructures. We will design, synthetize, and bio-functionalize nontoxic luminescent nanostructures, operating essentially beyond 1000 nm, for in vivo nanothermometry and nanoheating. Furthermore, to monitor the temperature-dependent nanostructures’ luminescence we will develop a novel imaging system. The effective delivery of that major advance in 2-D thermal bioimaging will be implemented through two impactful biomedical showcases: highly spatially-modulated intracellular magnetic/optical hyperthermia and in vivo detection and tracking of cancer.In the long-term, we foresee our technology having a broad impact on non-invasive clinical imaging and theranostics. For instance, the accurate measurement of temperature gradients´ sources will be an invaluable tool for real-time control of thermal therapies, thus making them harmless for the patient. Multiple con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a hydraulic installation for electro-hydraulic integration of hybrid surface actuation systems in on-ground rigs' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Clean Sky 2 aims to deliver full-scale in-flight demonstration of novel architectures and configurations. This ambitious goal implies the development of a huge number of innovative technologies and systems which must be properly tested on ground and in flight.Indeed, in the certification of any aircraft device, the qualification tests are essential and mandatory as part of the Validation & Verification process. This tests will enable demonstrate that the related equipment is compatible with all Environmental and Performance conditions put on top of the development phase and conceived during the requirements definition.Current trends in aeronautics lead to an increase in electrical systems, which must be combined with hydraulic ones, especially in critical aircraft control surfaces, as ailerons. Ensuring properly operation of both type of systems, stand-alone or integrated mode, is an essential step so developing test benchs fully representative of the A/C network will be a key issue.Under this framework, the project HYDRO_RIG 3G has been conceived to develop an A/C representative hydraulic installation that integrates all the A/C hydraulic system equipment, considering hydraulic generation and distribution and the corresponding sensors representative of flight test instrumentation (FTI) in order to reproduce complete A/C conditions that will be present in the Regional FTB#2 Demonstrator regarding to the actuation of hybrid surfaces as ailerons. The system will be designed fully representative of A/C environment like volume, pressure loss, etc. For this, it will be necessary to simulate all components that integrate the system. FTI sensors will be installed with a wireless system. Commercial components to be used in the hydraulic system shall be fully representative of A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'interactIVe' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The interactIVe project addresses the development and evaluation of next-generation safety systems for Intelligent Vehicles, based on active intervention. Safety technologies have shown outstanding capabilities for supporting the driver in hazardous situations. Despite their effectiveness, currently available systems are typically implemented as independent functions. This results in multiple expensive sensors and unnecessary redundancy, limiting their scope to premium-class vehicles.The project is based on the concept that by integrating applications together, vehicle components may be shared among the various safety systems. This is accomplished in interactIVe by discrete architectural layers that are common to all applications. These provide large amounts of knowledge about the driver, state of the vehicle, and the environment to all interested applications. The overall result is an optimal use of resources, lower implementation costs, and ultimately a much broader acceptance of the technology.Although application and sensor fusion is an active area of study, substantial amount of research is still required before its commercial feasibility. By building upon current state-of-the-art technologies, interactIVe will develop next-generation safety systems based on three pillar concepts, namely continuous driver support, collision avoidance, and collision mitigation.The core activities of the project will address the design and development of the Intelligent Vehicle Systems, whose capabilities will be shown in demonstrator vehicles. The project will be conducted through a coordinated effort from leading automotive industries, suppliers, and research institutes.By demonstrating these results, interactIVe will significantly enhance the feasibility and attractiveness of next
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A parallel optimisation scheme applied to extrusion die design', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The objectives of the project are to develop an automatic optimisation tool based on Polyflow which takes into account all aspects of die design.In particular this includes flow-balance adjustments, wall-temperature adjustments and front-face design. The project will validate the tool for rubber and PVC profiles and for medical applications. This will allow a comparison with the traditional 'trial and error' approach and a report on the economic benefits of the new tool will be a deliverable of the project. The use of the latest HPCN technology will reduce the computing time taken to design a complete die to less than one day on fast parallel computers. Simpler problems will take a similar time on a network of workstations. The problems to be tackled are numerically intensive because they involve non-linear fluid mechanics and optimisation and could not realistically be attempted without the use of high-performance computers. http://www.polyflow.be