RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Roles of non-coding RNAs in viral infections in mammals' to be submitted under Seventh Framework.

assistant: **Abstract**

The importance of small non-coding RNAs is growing exponentially in modern biology. They have recently emerged as critical regulators of gene expression. Different classes of small RNAs have been defined, and among them micro (mi) RNAs, and small interfering (si) RNAs are the most studied. Viruses interact extensively with the RNA silencing machinery. Thus in plants and insects, they are directly targeted and degraded by Dicer proteins. The situation is more complicated in mammals, where a more sophisticated innate immune response has replaced this antiviral mechanism. Nevertheless, there are interactions between viruses and mammalian RNA silencing pathways, which mainly involve miRNAs. On one hand, miRNAs of cellular origin can regulate viral RNAs, and on the other hand, some viruses have evolved to express their own miRNAs. This project aims at characterizing the full scope of interactions between mammalian viruses and the RNA silencing machinery. Using both RNA and DNA viruses, we will identify cellular miRNAs that have antiviral or proviral properties, and correlate these finding with the changes in cellular miRNA profiles induced by viral infection. We will set apart the mechanisms by which a given cellular miRNA has anti or proviral activity, and the counter methods that viruses could deploy to prevent their targeting. The second part of the project pertains to the study of viral miRNAs, and we will elucidate their roles both during in vitro and in vivo infection; we will also analyze how their expression is regulated. Finally, the last part of the project will consist in deciphering how viruses affect the RNA silencing machinery. This will entitle the characterization of RNA silencing complexes composition and subcellular localization during viral infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Majorana neutrino discovery strategy with CMS' (MajorNet).

assistant: **Concept**

The Large Hadron Collider at CERN is successfully operating at a record-breaking energy and is expected to deliver an enormous dataset of 300/fb of proton-proton collisions in the next 6 years. I propose to take advantage of both the unprecedented collision energy and the large number of events to be recorded in order to search for signs of new particles which could uncover the nature of dark matter, provide an explanation for the matter-antimatter asymmetry of the universe or answer questions about the origin of neutrino masses. To achieve this, I will build on my expertise devising and organizing new physics searches with leptons and will establish and lead a new multi-signature research programme at the CMS experiment. This programme will exploit both the intensity and energy frontiers opening up at the LHC and can be further expanded at the high-luminosity LHC (HL-LHC). Since the masses and couplings of the new particles are unconstrained, my proposed search strategy will be such that a wide mass range will be covered also encompassing many orders of magnitude in the coupling strength.


**Keywords:** LHC, CMS, Majorana neutrino, dark matter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design, analysis and applications of novel information processing paradigms for multimedia transmission in next generation wireless networks""' in the context of a Seventh Framework call.

assistant: **Objectives**

Communicating multimedia content such as high-quality images, audio or video streams became a part of everyday life both for the purpose of business and entertainment. As user mobility and need for multimedia content available anytime and anywhere increases, multimedia applications such as video streaming, mobile TV, video-conferencing, multimedia peer-to-peer networking, social networking with multimedia content, interactive gaming, etc., are becoming a major bandwidth consumer on small, handheld, mobile devices and are indicated in many recent studies as a major driving factor for the next generation mobile broadband technologies. This is evident both in the user equipment such as smart phones, portable digital assistants and tablets, for which the screen size and resolution is ever-increasing and constrained only with the comfort of the device usage, as well as in the development of the fourth generation high-speed wireless data interfaces such as Mobile WiMax (IEEE 802.16e-2009) and 3GPP LTE-Advanced that aim to provide sufficient data rates for comfortable high-quality mobile multimedia services. Recently introduced groundbreaking information-processing paradigm called network coding opens a novel set of possibilities for improvements of network performance in terms of throughput, reliability and delay. However, even though it usually provides more bandwidth, a number of problems arise in successful integration of network coding principles into multimedia communications in current wireless communication systems. This proposal aims to address the problem of design of efficient network coding schemes for scalable multimedia delivery in wireless networks. The goal of this project is to provide both rigorous theoretical and realistic system-level investigation of netwo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tensoring Positive Maps on Operator Structures' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Many important problems in quantum information theory can be formulated in terms of how linear maps between matrix algebras behave under tensor powers. Examples include the distillation problem (fundamental for quantum communication), the problem of local entanglement annihilation (important for entanglement distribution in quantum networks), and the PPT squared conjecture important for (quantum key repeaters). Despite their importance for quantum communication, these problems are wide open, and no general theory is known for solving them. I realized that these problems can be formulated in the framework of abstract operator systems. Here, they correspond to characterizing which linear maps stay positive under tensor powers with respect to different operator system structures over the matrix algebras at the input and output. Completely positive maps and completely copositive maps (compositions of completely positive maps with a transposition) are always trivial examples, corresponding to known examples in quantum information theory. The question is, whether other examples exist. So far this type of problem has only been studied (indirectly) in the few special cases of operator systems over the matrix algebras corresponding to the above problems. There is a much richer theory of abstract operator systems (even over the matrix algebras) and different tensor products to combine them. In my project, I want to study such tensorization problems for other operator system structures over the matrix algebras and beyond. I want to understand how properties of these structures affect properties of linear maps under tensor powers, and find settings where only the trivial examples of completely positive and completely copositive maps stay positive under any tensor power. Finally, I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enabling Technologies for Large-Scale Sensor and Control Networks' in the context of a Seventh Framework call.

assistant: **Objectives**

The vision of an interconnected world where wireless sensor, actuator and controllers are embedded everywhere is materializing. The next step in this evolution is to automatically act on the physical environment based on sensor measurements. Examples of such large-scale networked control systems are found in smart grids, intelligent transportation systems, process and automation industries, e-health, and in surveillance, monitoring and early-warning systems. Using current technologies these types of networks will create an unprecedented amount of raw data, which will soon exceed current storage and processing capabilities. Promising concepts such as compressive sensing, distributed compression, cooperative transmission networks, networked control, and information-theoretic security are emerging as potential enabling technologies. Together the program partners have expertise across these areas.The objectives of the proposed collaborative exchange program are threefold. Firstly we aim to identify and solve relevant theoretical challenges in compression, transmission, networked control, and security by leveraging on the recognized complementarities and synergies between partners. Secondly we want to ensure a high level of collaboration and knowledge transfer across all partners such that we can jointly embark on grand challenges ahead. And thirdly, our proposed research is to a large extend relying  on existing research projects of common interest to leverage new ground with a high potential for leading into new joint projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evaluation of the safety and efficacy of iron supplementation in the pregnant women' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Recent developments in biotechnology (cell transfection, clone development), bioengineering (microtechnology) as well as high throughput screening (HTS) open new directions with respect to integrated systems for drug screening and target discovery. New techniques allow immobilization of single biomolecules as well as imprinting of key-structures on surfaces. Cells can be designed by tranfection techniques to express defined sets of target structures linked to reporter functions. Molecules for cell anchoring can be used for seeding of the designed cells on adhesive patterns. Existing concepts of ultra-high throughput screening will be adapted to new integrated micro carrier systems in order to improve sensitivity, specificity and speed as well as to extend the application range.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Post-transcriptional regulation of Germline Stem Cells (GSCs) maintenance' (GSCs).

assistant: **Concept**

Adult stem cells (SCs), also known as tissue SCs, support tissue homeostasis and repair throughout the entire life of the organism. The remarkable longevity of tissue SCs relies on their unique ability to asymmetrically generate new SCs (self-renewal) as well as specialized cell types (differentiation). Notably, many genes that signal to regulate the balance between renewal and differentiation encode proteins as well as small RNA molecules, predicted to regulate specific mRNAs. This proposal is aimed to uncover RNA regulation networks essential for maintaining an adult germline stem cells (GSCs) pool, and for preventing differentiation along the germline lineage. Ultimately, I wish to understand in molecular details how the activities of diverse post-transcriptional factors are coordinated in space and time to give a functional tissue homeostasis. Using the Drosophila testis - a stem cell based tissue model in which stem cells and the niche have been defined and can be manipulated, I aim to investigate SCs regulation by conserved RNA regulators. To pursue these interests I will use a variety of biochemical and genetic assays in the highly genetically amenable model organism, Drosophila melanogaster.Given that tissue homeostasis and repair supported by adult SCs is a primordial mechanism of multicellular animals, I anticipate the functional importance of many of the genes to be identified will be conserved between flies and mammals. Understanding the mechanistic basis of adult SC self-renewal, as well as of regulating the differentiation and proliferation of their progeny, will ultimately facilitate stem cell based therapies for regenerative medicine including age-onset diseases and cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modelling of Oxide Interfacial Reconstruction' under Horizon 2020.

assistant: **Concept**

One of the most challenging problems in material science is establishing a relation between material’s properties and interfacial structure. The presence of interfaces may strongly affect the properties of most polycrystalline materials. Interfaces play a determining role in properties of functional oxide heterostructures – artificial materials that attracted an increased attention over the past decade due to the wide range of properties they exhibit. The ability to predict equilibrium atomistic structure of interfaces in multicomponent systems using theoretical methods would provide a better understanding of the relation of interfaces to the physical properties of materials.The OXIREC project aims to develop a robust and efficient methodology for theoretical prediction of structural reconstruction at complex oxide interfaces. The project addresses an insight into the principles of interfacial reconstruction in several technologically important heterostructures.The outcome of the project will provide a great fundamental impact opening pathways for prediction various systems with desired properties, as well as a practical impact for oxide industry and manufacturing technologies.


**Keywords:** interfacial phenomena, oxide interfaces, oxide heterostructure, functional materials, structure prediction, density functional theory, defects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global mass balance of persistent semi - volatile organic compounds: An approach with PCB as an indicator' (GLOBAL-SOC).

assistant: **Concept**

Several studies show that a large number of semi-volatile organic compounds (SOCs), and among them polychlorinated biphenyls (PCBs), are global pollutants. Atmospheric concentrations of PCBs in remote locatlons have not decreased or decreased very little since the 1970s, despite regulations that have drastically decreased the production of PCBs. This is a cause of concern since some PCB congeners are likely to cause toxicological effects at the present levels. Are PCB concentrations maintained by continuos diffuse emissions or are old emissions of PCBs being recycled? What is the rate of decrease in remote areas of the globe for different PCB congeners? The proposed project aims to address and quantify the major global loss rates which will also help answer to the question: where will the PCBs end up? In deep-sea water? Coastal sediments? Soil? Or chemically transformed to other substances? Preliminary global mass balance calculations point to the fact that all of these processes may be of significance for the environments capacity to remove pollutants on global scale. The proposed project will therefore be divided into sub-projects focusing on these different processes. Additional sub-projects will be modelling and compilation of data from other sub-projects, emission estimates for the completion of the global mass balance, and a quality assurance program to ensure the quality of all data generated within the project. GLOBAL-SOC involves several aspects of method development and innovative approaches to the assessment of SOCs fate in a global perspective. These issues are of fundamental concern for the environmental policy of the European Union and its individual member states. SOCs are typical transboundary pollutants which must be addressed in international collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Einstein gravity and nonlinear waves: physical models, numerical simulations and data analysis'.

assistant: **Innovation**

The study of nonlinear waves on curved geometries have been increasingly important in physics and engineering, for example to model and built more efficient and environmentally friendly materials. The difficulty in dealing with those wave equations, including the Einstein equations, led to impressive recent developments of geometry and analysis as well as powerful numerical methods requiring the highest computer power. In turn, the recent observations of the most challenging wave signals such as gravitational waves ignited unprecedented investment on experiments and data analysis. The EinsteinWaves network will allow interdisciplinary mobility and training of researchers in the new methods and techniques that will make possible previously intractable analysis relevant to current and near-future developments of computational methods and experiments. Gathering an unprecedented team of top researchers in mathematics, theoretical physics and computation, we intend to employ our expertise to provide a unique opportunity for new career development perspectives. The activities will include network courses, workshops and engagement with active cutting-edge research. EinsteinWaves is set up to integrate several existing and highly recognized annual conferences with a series of new schools and workshops including non-academic participants. Through developing invaluable analytic, computational and soft skills, researchers will develop the potential to become the next generation of European leaders in academia, industry, and the public sector. Finally, the training we offer and the research carried out, will be made open and available, boosting Europe's leadership in fields of analysis, mathematical physics and computational methods.


**Keywords:** General Relativity, Black Holes,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'EU Patient- cEntric clinicAl tRial pLatform'.

assistant: **Concept**

EU-PEARL has the ambition of transforming the current approach of conducting single-compound clinical trials into the use of cross-company Integrated Research Platforms (IRPs), taking into consideration both patients’ interests and the opportunities from novel molecules for addressing medical needs. Patient-centric data and knowledge sharing have the potential to accelerate the development of new treatments and reduce the operational costs of clinical trials. EU-PEARL will improve clinical effectiveness, patients’ satisfaction and societal access to timely and affordable medicines and it will shape the clinical trials of the future. This will change the industry paradigm from competition to cooperation in four disease areas and provide the framework for designing IRPs in other disease areas.The main objectives of EU-PEARL are: (1) To create a reusable, accessible and sustainable modular IRP for the design and execution of patient-centric, cross- company IRP in any disease area with unmet needs;  (2) To set up the open, dynamic, patient inclusive IRP governance structure that will manage the appropriate regulatory, ethical, legal, statistical and data utilisation requirements of the IRP; (3) To disseminate and exploit the EU-PEARL paradigm through the provision of the necessary common tools, procedures, expertise and operational skills working to the highest scientific, regulatory and ethical standards and best practices, developed jointly by public and industry partners in a consensus-based approach; and (4) To create trial-ready IRP networks in the four disease areas of Major Depressive Disorder (MDD), Tuberculosis (TB), Non-Alcoholic Steatohepatitis (NASH) and Neurofibromatosis (NF).


**Keywords:** platform trial operations, Bayesian statistics, data governance, sust