RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Crystal structures of PIN proteins - CrysPINs' (CrysPINs) under Horizon 2020.

assistant: **Objectives**

The main goal of the “CrysPINS” project is to derive a model for the structure of PIN1 protein, starting with a loopless version (PIN1loopless), and optionally other PIN proteins, using techniques of molecular biology, biochemistry and crystallography. Members of PIN family are plant-specific auxin transporters, which play crucial role in plant morphogenesis, development and responses to the environment. Although it is well known that PIN proteins drive polar auxin transport, till nowadays the auxin research community is missing detailed functional and mechanistic models of these enigmatic transporters. My considerable experience from studying auxin metabolism and transport on the cellular and plant level, combined with the expertise at the University of Warwick in auxin recognition and the structural biology of mammalian membrane transporter proteins, makes it timely to move the science forward by a project focussed on the structure of PINs. My vision is that we will be able to develop a detailed molecular map of PINs together with associated pharmacophoric map for their substrates and inhibitors, a goal that will offer me an ideal system for further research focused on PINs auxin substrate specificity and transport capacity. On the way I will expect to reveal how the PINs are energized, and create links with the auxin herbicide industries to explore opportunities for collaborations on agro-pharmaceutical compound design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ionic Liquid Interface Dynamcis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of the project is to take the ground-breaking step from our present knowledge of static properties to the understanding and control of dynamical processes at ionic liquid interfaces. Ionic liquids (ILs) are chosen as model systems for liquids in general for two reasons: First, their structural diversity allows their properties to be tailored over a wide range, and second, they can be studied using the extremely powerful methods of surface science in ultra-high vacuum due to their low vapor pressure. Such studies cannot be performed for conventional liquids, since they evaporate. ILs are not only relevant from a fundamental point of view, but also for a variety of applications. In catalysis, two new concepts have been put forward: Supported Ionic Liquid Phase (SILP) and Solid Catalyst with Ionic Liquid Layer (SCILL). In both, a high surface area solid substrate is covered with a thin IL film, which contains a dissolved metal complex for SILP, or which modifies active sites at the support for SCILL. For these and other applications, a fundamental understanding of the dynamical processes at the gas/IL and/or IL/support interfaces is strongly needed, but does not exist. Equally important, but even more challenging, is the investigation of the dynamics of chemical reactions in ILs, also under electrochemical conditions.Therefore, the applicant proposes a multi-method approach with new and unique setups to follow these dynamical processes in real time, that is, while they occur. Towards this goal, four key topics will be addressed: (A) How do gases pass through the gas/liquid interface? (B) How does the liquid/solid interface form? (C) Real-time studies of reactions in ILs, and (D) Real-time studies of electrochemical processes in ILs. The achieved insight will then e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trusted and QoS-Aware Provision of Application Services' to be submitted under Fifth Framework.

assistant: **Abstract**

The overall objective of the TAPAS project is to develop novel methods, tools, algorithms and protocols that support the construction and provisioning of Internet application services.Objectives:The project will achieve the overall objective by developing QoS enabled middleware services capable of meeting Service Level Agreements (SLAs) between application services and will enhance component based middleware technologies such that components can be deployed and interact across organisational boundaries. The project will develop notations for expressing SLAs to enable specification of QoS, such as the availability as well as trust relationships. SLA trust specifications will be used for deriving service invocation primitives enriched with authentication, non-repudiation mechanisms, with or without the involvement of trusted third parties.Work description:TAPAS is structured into four technical workpackages(WPs). - WP1 will develop notations for expressing SLAs to enable specification of QoS as well as trust relationships. Model checking capabilities will be developed to support reasoning about QoS characteristics of components and their composition. The project will adopt UML as the language for the description, modelling and analysis and extend it with formally defined stereotypes and properties.SLAs are only useful if their compliance is enforced and monitored. To achieve this aim TAPAS will use SLAs not only as an inter-organisational contractual feature but also to govern component execution.- WP2 will develop support architectures that provide QoS negotiation, establishment and adaptation facilities to enable component containers to become QoS enabled. SLA trust specifications will be used for deriving service invocation primitives enriched with authentication, non-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Construction Of Novel CERTification methOds and means of compliance for disruptive technologies' in the context of a Horizon Europe call.

assistant: **Objectives**

Clean Aviation’s ambition to go over decisive impactful steps in demonstrated disruptive aircraft performance compatible with 2035 EIS will only be possible if the future regulatory framework is not an impediment to innovation. Certification shall still improve safety while shortening time to bring new safe products to market and into service, and maintaining European leadership and competitiveness. Having de-risked the certification path is an important step.The project will deliver a comprehensive set of regulatory materials on certification together with preliminary description of methods of compliance applicable to the three ""thrusts"" of Clean Aviation and a first status of comprehensive digital framework of formalized collaborative tooled and model/simulation-based processes for certification.Critical challenges, tackled through Proof of Concepts for the regional and short and medium range aircrafts, including hydrogen, will be easily transposable and scalable to different product lines and aircraft segments such as general aviation, rotorcraft, business jets or commercial medium-long range affecting the complete fleet.This initiative represents a tremendous opportunity to reinforce European leadership and sovereignty in leveraging our position as the forerunner of worldwide new certification frameworks. The composition of the project consortium reflects a smart mix of aircraft manufacturers (CS-25, CS-23), engine manufacturers (CS-E), equipment manufacturers, research centres, universities, SME and PLM experts. Playing a pivotal role between innovation and the development of safety, security or environmental protection standards, the involvement of EASA experts acting together with industrial and research technical teams for the conception, endorsement of new so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Safe and sUstainable by desigN Strategies for HIgh performance multi-component NanomatErials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main goal of SUNSHINE is to develop and implement S&SbD strategies for products enabled by multi-component (advanced) nanomaterials (MCNM), including high aspect-ratio nanomaterials (HARNs). To this end, the project will generate essential knowledge, tools and data on the exposure, hazard and functionality characteristics of these materials, especially those arising from their unique properties and interactions (e.g. mixture effects due to the multi-component nature of the materials). To facilitate the uptake and utilisation of the S&SbD strategies by industry, especially SMEs, we will deliver them as part of a user-friendly e-infrastructure designed to: (1) facilitate collaboration and information exchange between actors along nanotechnology supply chains (developers, producers, downstream users) to promote the development and implementation of S&SbD strategies for MCNM-based materials, products and processes; (2) support SMEs and large industries in the selection and application of simple, robust and cost-effective experimental, modelling and grouping/read-across approaches to acquire/generate the data needed to test the effectiveness of the S&SbD strategies; (3) enable risk-benefit analysis of the S&SbD-modified materials and products at each stage of the innovation process to ensure that they are safe for the human health and the environment without compromising their technical and/or commercial probability of success  The S&SbD strategies that are effective in reducing the risks from MCNMs, while retaining product performance and economic viability, will be proposed for full scale industrial implementation. In addition, the project will contribute to Regulatory Preparedness by providing recommendations on improvement and adaptation of the current regulatory haz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Federated and distributed inference leveraging sensing and communication in the computing continuum' under Horizon Europe.

assistant: **Concept**

The integration of sensing and communication is attracting a fervent research activity and will result in a myriad of contextual data that, if properly processed, may enable a better understanding of local and global phenomena while increasing the quality, security, and efficiency of our ecosystems. The computing continuum offers a timely and unique solution for processing such a massive volume of sensed data, as it provides virtually unlimited and widely distributed computing resources. Nevertheless, the deployment of data analysis at the edge or in the cloud has many implications regarding latency, privacy, security, and data integrity. As we learn how to sense ubiquitously and we build a tool able to handle the sensed data, the greatest challenge is to understand how and where to process them. The purpose of this project is the development of a pioneering framework to guide the design of federated and distributed inference systems, leveraging sensing and communication and harnessing the computing continuum. The framework will build on: (i) the definition of statistical and mathematical models for the sensed data, which capture the complex and interrelated phenomena underpinning sensing and communication systems, with different levels of integration; (ii) the development of cloud-native inference algorithms, mainly distributed and parallelized, with scalable complexity that can be adapted to dynamic performance requirements; (iii) the design of orchestration strategies to guide the flexible deployment of the inference process at the edge and in the cloud with a dynamic allocation of the computing resources. The aim is to overcome the paradigmatic accuracy-complexity trade-off that has driven distributed inference for decades, leading to a paradigm shift that encompass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Future Formulations: Developing Future Pharmaceuticals Through Advanced Analysis and Intersectoral Exchange'.

assistant: **Innovation**

The estimated cost of getting a new medicine to market is now in excess of $2.6 billion, with an additional $300 million (approx.) typically being directed towards post market approval research and development activities (including testing of new indications, new formulations and new dosage strengths and regimens) (Nature Reviews Drug Discovery 13, 877 (2014)). These costs have increased >145% since 2003, and reflect an increasingly complex process in which there remains a high chance of failure in the expensive later phases of development. With the aim of reducing the times and costs associated with medicine development, increasing attention has focused on the development of approaches to better predict and/or optimize the behaviour of actives and their formulations at an earlier stage of development. Recent research within the School of Pharmacy (University of Nottingham (UoN)) has focussed on the application of advanced surface analytical and biophysical tools to address this need. This proposal will build on this activity via an intersectoral researcher exchange program focussed on supporting future pharmaceutical formulations development.The principal objective of FutForm is to translate the advanced analytical approaches developed within UoN, so that they become embedded into industrial practice for the development of future pharmaceutical processes and therapies. This will be achieved through a collaborative programme of researcher secondments with three small-medium enterprise (SME) companies, each with early stage innovative technologies in areas of importance to the future pharmaceutical industry, namely; enzyme formulations for improved cell isolation (Abiel s.r.l; Italy), nanoparticle platform formulations for oral and topical drug delivery (Inovapotek, Phar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synergising International Research Studies into the Environmental Fate and Behaviour of Toxic Organic Chemicals in the Waste Stream' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The overall vision of INTERWASTE is to develop scientific understanding of issues related to environmental contamination with toxic organic chemicals (specifically flame retardants (FRs) and pharmaceutical and personal care products (PPCPs)) arising from their presence in the waste stream. Specific research objectives include: (a) exchange of knowledge of and best practice in methods for rapid and cost-effective identification of waste items containing restricted FRs; (b) developing scientific understanding of environmental contamination due to processing of waste items containing FRs; and (c) furthering understanding of the sources of PPCPs and FRs in the sewerage system. To facilitate such research on the global level required, INTERWASTE will exchange best practice in the analytical chemistry techniques required to study FRs and PPCPs, and evaluate the measurement capability of INTERWASTE participants via an interlaboratory comparison. INTERWASTE's vision will be achieved via a co-ordinated programme of collaboration and research secondments between world-leading research groups both within and outside the EU; coupled with annual workshops to discuss the latest findings. The research programme will exploit the complementary expertise of the consortium members, and in so doing foster synergies. Cross-sectoral interaction and knowledge sharing will be achieved via the participation of beneficiaries and partner organisations from both academic and non-academic sectors. All secondments and workshops will be conducted within a framework designed to maximise the training and career development benefits to participating staff by providing them with opportunities for knowledge and skills acquisition, with a particular (but not exclusive) focus on early career researchers. IN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'DEMONSTRATION OF NUTRITIONAL FUNCTIONALITY OF PROBIOTIC FOODS'.

assistant: **Objectives**

Functional foods incorporating probiotic bacteria with scientifically supported health claims have great potential for improving the quality of life and already constitute a rapidly growing EU and export market. The European food industry, however, is facing an alarmingly growing competition on the European and International markets from large American and Japanese food producers. However, considerable confusion and scepticism exists on the side of consumers, consumer organisations, and scientific community about the claims associated with probiotic products. This greatly hampers further exploitation of functional foods from probiotic bacteria and weakens the market position of European producers in the face of competition. To eliminate these hurdles, speed up adaptation of the probiotic food technology and enhance the attractiveness of new probiotic foods, it is essential to demonstrate the up-to-date basis for marketable claims by :- presenting the health and nutritional benefits of probiotic bacteria and foods, with special emphasis on intestinal integrity and immune modulation;- exploiting validated methods for the selection of novel probiotic bacteria and foods, and- disseminating the obtained knowledge to the extended audience consisting of both industries, authorities and consumers.The project will be divided into four interactive tasks :- selection and verification of probiotic strains;- pilot testing by clinical human trials in children and adults;- demonstration of probiotic properties and fermentation technologies to establish the desired effects;- dissemination of knowledge to extend audiences.The clinical trials and novel methods to measure health beneficial claims are essential for making approval of such claims possible by the authorities and to obtain so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Virtual Environments for Social Training' (VEST) under Horizon 2020.

assistant: **Objectives**

Autism spectrum disorder (ASD) is a clinical diagnostic label used to characterize a wide array of individuals exhibiting some common degree of core difficulty in the domain of social communication. This difficulty is reflected in contextually inappropriate social behavior, limited understanding of social norms, expectations, and others’ mental states, eye gaze abnormalities, etc. Such impairments often lead to social exclusion and failure to develop age-appropriate peer relationships. Although current behavioral interventions for autism show some effectiveness, their generalizability is limited insofar as they are often set in structured settings that are decontextualized from situations of everyday life.  Also, most of the interventions that have been effective tend to train skills that do not pertain to core areas of social communication where individuals with autism encounter difficulties (e.g. they target improvements in language, IQ etc.). To overcome the shortcomings of traditional interventions we have begun exploring how to train social skills through interactive role-playing scenarios experienced through immersive Virtual Reality (VR).  With VR autistic individuals can practice, in realistic but safe environments, useful and typical tasks from everyday life. We have designed a prototype software package with a number of tasks embedded in virtual environments aiming at (1) capitalizing on known cognitive strengths of autistic individuals (e.g., good skills in visual search) and generalizing them to social settings, and (2) improving the transfer of skills across tasks that are conceptually similar despite surface differences. This software runs on a variety of platforms including low-cost Head-Mounted-Displays and 3D TVs. Based on what we know about autism and