RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Getting to the root of ageing: somatic decay as a cost of germline maintenance'.

assistant: **Concept**

The trade-off between survival and reproduction lies at the core of the evolutionary theory of ageing. Removal of germ cells extends somatic lifespan implying that reduced reproduction frees up resources for survival. Remarkably, however, the disruption of germline signalling increases lifespan without the obligatory reduction in fecundity, thus challenging the key role of the survival-reproduction trade-off. Recent breakthroughs suggest that protection and repair of the genome and the proteome of the germ cells is costly and compromised germline maintenance increases mutation rate, which can reduce offspring fitness. Thus, expensive germline maintenance can be a missing link in the puzzle of cost-free lifespan extension. This hypothesis predicts that when germline signalling is manipulated to increase investment into somatic cells, the germline maintenance will suffer resulting in increased mutation rate and reduced offspring fitness, even if total fecundity is unaffected. I propose a research program at the interface of evolutionary biology and biogerontology that focuses on phenotypic and evolutionary costs of germline maintenance. First, I will genetically manipulate germline signalling to boost investment into soma and estimate mutation rate and competitive fitness of the resulting offspring using Caenorhabditis elegans nematodes. Second, I will employ experimental evolution in nematodes to assess the long-term evolutionary costs of increased germline maintenance. Third, I will use germline transplantation in zebrafish Dario rerio to directly test whether germline proliferation reduces investment into soma in a vertebrate. Understanding how increased investment into the soma damages the germline and reduces offspring fitness will provide a major advance in our unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'FRET-based receptor screening assays'.

assistant: **Objectives**

This project intends to prepare the commercialization of a new, patent-protected, generic technology to identify and characterize potential drugs acting at G-protein-coupled receptors (GPCRs). GPCRs represent prime targets for therapeutic drugs, variously estimated at 25-50% of all therapeutic targets, including multi-billion € drugs for major diseases, such as beta-blockers or antihistamines. However, of the hundreds of GPCRs, only 82 are currently used as therapeutic targets, and many still lack the identification of their endogenous ligands, indicating the vast potential of these receptors for further drug development.The project is based on results of the ERC-AdG “TOPAS” (ID: 232944), where we have developed sensors for receptor activation and signaling based on fluorescence resonance energy transfer (FRET). In particular, we have developed new sensors that contain a GPCR and two fluorophores, capable of directly reporting receptor activation. The University of Würzburg has obtained broad patent rights for such sensors.Such FRET-based receptor screening assays (FRESCA) have the potential to discover new, innovative GPCR drugs. We intend to explore the usability and scalability of FRESCA for drug screening purposes in the pharmaceutical and biotech industry. We will validate FRESCA in comparison to current standards, and under high-throughput screening conditions. We expect that FRESCA can replace standard radioligand binding assays as the first line of drug screening. FRESCA further show the potential to define the properties and effects of drug candidates at GPCRs, by measuring directly the activation step (conformational change) of GPCRs rather than the many different downstream steps that are activated by GPCRs. This indicates the broad applicability of FRESCA as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chiral based spin organic light emitting diodes' (SOLED) under Horizon 2020.

assistant: **Objectives**

Organic Light-Emitting Diode (OLED) is an attractive solution for displays and lighting due to its low cost of production. The adoption of OLED technology in televisions, smartphones, and increasing number of applications in wearables, transportation and lighting are contributing to the growth of this market. OLED technology offers sharper images, better contrast and crisp colours than any existing display technology.In lighting applications the efficiency of serial production OLEDs cannot currently reach the efficiency of fluorescent lamps and Light-Emitting Diodes (LED). Also, OLEDs are only marginally more energy efficient than the best LCD displays. In the spin-LED/OLED concept, the electrons injected into and from the light-emitting species have their spin predetermined; therefore, the formation of “dark”, non-emitting triplet states is avoided. Based on our research on the chiral induced spin selectivity (CISS) effect, we propose to develop chiral organic semiconductor structures that provide a universal means to control the spin state of injected electrons and holes in OLEDs.  This effect can increase the energy efficiency of the devices by a factor of four. In this proof-of-concept project we will develop, manufacture and test state-of-the-art chiral molecules based spin-LED/OLED structures, which are expected to improve the energy efficiency of LEDs and OLEDs, a critical issue in view of the desire to reduce the energy consumption of electronic devices. The efficiency is expected to improve by a factor of four. The project also takes pre-commercialisation measures and carries out networking actions for preparing optimally to the commercialisation of the spin-OLED technology developed in the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EFFICIENT URBAN TRANSPORT OPERATION SERVICES CO-OPERATION OF PORT CITIES IN EUROPE' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

EUROSCOPE aims at cooperation between European cities - most of them having a major port - to develop and demonstrate advanced transport telematics systems across Europe for the benefit of travellers and passengers, transport systems operators and freight carriers. It pursues previous EU research by a consortium including local authorities, public transport operators, ports and trans-shipment centres, transport consultancies and researchers. The work will focus on many aspects of smoother transport operations, among them planning, information on timetabling, route guidance and incident management. A horizontal work package will cover specialist evaluation to ensure comparable results with a demonstrable European dimension.The EUROSCOPE project builds upon the results of the DRIVE II programme. The partners are Köln, Hampshire County, Piraeus, Rotterdam, Strasbourg, Genoa, Hamburg, and the followers Cork, Brandenburg ensuring a strong political support. EUROSCOPE was initiated by the POLIS network and builds upon the results and infrastructure produced in the SCOPE project and is substantially enhanced to further develop and demonstrate wider ATT applications. The consortium includes public transport operators, port and transhipment centres, industrial system providers, broadcasters, transport consultancies and research specialists that bring considerable expertise and experience from the previous programme. The emphasis of the project is on the development and provision of demonstrators which have direct application for the cities, port or operator and which can be interoperable throughout Europe. The Cities are most concerned that the project must address user needs and have direct application.The objective of EUROSCOPE is Demonstration and Validation of Advanced Trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Downhill Folding Protein Modules as Conformational Rheostats: Roles in Molecular Biology and Applications as Biosensors'.

assistant: **Objectives**

Protein folding and function is a perfect arena towards growing the grassroots of quantitative and synthetic biology. This is so because all cellular processes controlled by proteins can ultimately be traced back to physico-chemical properties encoded in their aminoacid sequences. MOLRHEOSTAT is framed within these goals, focusing on the investigation of novel connections between protein folding and function via a multidisciplinary approach that combines experiment (single molecule spectroscopy, high-resolution NMR, protein engineering and design), theory and computer simulations.Conventionally, proteins are portrayed as conformational switches that fold and function by flipping between an on-state (native, active) and an off-state (inactive, unfolded) in response to stimuli. However, last years have witnessed the discovery of protein modules that undergo continuous conformational changes upon unfolding (downhill folding).  MOLRHEOSTAT aims at investigating the functional and technological implications of downhill folding. The goal is to determine whether downhill folding modules can be exploited to build conformational rheostats; that is, proteins that continuously modulate a signal or response at the single molecule level by tuning their folding conformational ensemble. Conformational rheostats could open a new realm of applications as synthetic biomolecular devices as well as regulatory mechanisms for controlling complex biochemical processes carried out by macromolecular assemblies. These ideas will be explored on two specific objectives:1) Implementation of a general approach for building high-performance, ultrafast, single-molecule sensors based on downhill protein folding modules.2) Analysis of the roles of conformational rheostats in the regulation of three fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gas-phase reactions of nitrate radicals with phenols' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Phenols are produced in the atmosphere from the oxidation of aromatic compounds. They are highly reactive under atmospheric conditions and can therefore contribute to urban air pollution. The degradation of phenols in the troposphere is mainly initiated by hydroxyl radicals during the day and nitrate radicals at night. In order to ascertain the true environmental impact of phenols a thorough knowledge of the rates and mechanisms for their atmospheric degradation is required. This project has two main research objectives:(i) to determine rate coefficients for the reaction of nitrate radicals with a series of methylphenols and dimethylphenols.(ii) to identify and quantify the major oxidation products of the nitrate radical initiated oxidation of methyl- and dimethylphenols. Laboratory studies will be performed in a new environmental (smog) chamber designed for the studyof gas-phase processes under atmospheric conditions. Chemical analysis of reactant/product mixtures will be provided by in situ FTIR spectroscopy and GC-MS. Chemical mechanisms for the nitrate radical initiated oxidation of phenols will be constructed. The mechanisms will be made available to collaborating laboratories within Europe for inclusion in photochemical models that are used to predict secondary pollutant formation. It is envisaged that the inclusion of this chemistry will improve the accuracy of such predictions and lead to an improved understanding of the environmental impact of phenols.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EISCAT_3D: A European three-dimensional imaging radar for atmospheric and geospace research (Preparatory Phase)' (2007-2013).

assistant: **Concept**

EISCAT_3D is a next generation incoherent scatter radar system for high-latitude atmosphere and geospace studies that will be built in northern Fenno-Scandinavia. The facility will consist of multiple large phased-array antenna transmitters/receivers in three countries, comprising tens of thousands of individual antenna elements. The new radars will collect data from the upper stratosphere to the magnetosphere and beyond, contributing to the basic, environmental and applied science that underpins the use of space by contemporary society. EISCAT_3D's capabilities go beyond anything currently available to the international research community and will constitute a valuable scientific resource for the European Research Area.Located in the auroral zone at the edge of the northern polar vortex, EISCAT_3D will provide long-term continuous data for scientists studying global change, measuring the effects of man-made and natural variability on the middle and upper atmosphere. Its observations will underpin space weather prediction and monitoring, essential for the operation and the improved service of European space assets. In addition EISCAT_3D will facilitate studies of solar system influences on the terrestrial environment, such as solar wind, meteors, dust, energetic particles and cosmic rays, in collaboration with other research infrastructures.The Preparatory Phase will resolve the remaining legal, financial and technical questions which must be addressed before the construction of EISCAT_3D.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'East European Co-operation Network for International Joint Training in FP6/FP7 Food Quality and Safety for EU-Russia-Ukraine-Armenia-Belarus (R-U-A-B) Countries' (R-U-A-B) targeting FP6.

assistant: **Abstract**

InJoy and Train is a 24 months Specific Support Action which aims at improving the quality and quantity the participation of researchers, multipliers and NCPs in the Food sector from R-U-A-B countries in European research. This objective is relevant and responds to the following major needs of policy coordination in the Food sector: i) Despite the existence of highly skilled individuals and institutions in R-U-A-B countries, participation in EU FPs is low. It is in the interests of the construction of the ERA that this participation be increased; ii) There is a lack of knowledge among Researchers, multilpiers and FP6 NCPs from R-U-A-B countries on the Food Quality and Safety sector in FP6; no NCP for the Food priority exists in either Ukraine, Belaruss or Armenia. iii) There is a need for capacity building in project proposal and submission procedures under EU FPs in R-U-A-B countries; iv) There is a need to raise awareness in Europe of skilled potential partners from R-U-A-B countries to be involved in EU FPs in the Food Quality and Safety sector. To achieve the overall objective, a multi-skilled consortium, led by an expert institution in EU research policy, has been established in order to pursue 3 main workpackages covering the: i) Creation of a pro-active network of Researchers and multipliers in R-U-A-B countries, ii) Training of Researchers, multilpiers and FP6 NCPs from -U-A-B Countries in the legislative and institutional environment of the Food sector in Framework Programmes. Member state consortium partners will train R-U-A-B project partners who will then train the R-U-A-B researchers and multipliers; iii) Awareness raising in Europe of skilled and potential partners from R-U-A-B countries available to take part in the Food Priority of FPs. The strengthening
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Doctoral Network for Safe and Sustainable by Design Electromagnetic Shielding Material' (PARASOL).

assistant: **Concept**

•PARASOL is a Doctoral Network at the intersection of electromagnetic compatibility (EMC), materials engineering, system-safety engineering, and sustainability management. The project will include the Safe and Sustainable-by-Design (SSbD) approach for vehicles. The project researches electromagnetic (EM) shielding solutions, which are performances-defining technologies in terms of EM safety, weight, volume, mechanical strength, and the cost of a vehicle. •PARASOL’s science case is based on the integration and optimisation of every KPI in the SSbD approach. This requires thinking in terms of a trade-off across a new mix of disciplines, to develop innovative solutions accordingly, and to consider all the far-reaching societal and technical consequences of the design choice. Up to now, even most high-tech industries are forced to manufacture several prototypes and perform tests, because the actual performance of shielding in the final vehicles is unknown. A characterisation strategy embedded in the SSbD approach is urgently needed.  •PARASOL is the first training network dedicated to the inclusion of the SSbD approach in the design of electronic equipment. It answers the recently highlighted, pressing need for trained specialist in the field. •PARASOL involves 5 academic Beneficiaries and 15 industrial Associated Partners, across the complete lifecycle of design solutions, from 8 countries. A pan-European approach in a multi-sectoral context is guaranteed (universities, an established start-up, SMEs, and major industries), while representing all types of vehicles (land, air, marine).•PARASOL will train a new generation of scientific professionals who can transition between disciplines and take up leading positions in the field of electronics, safety, and sustainability, wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The development of novel carriers for gene therapy of tumours' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The purpose of this project is to develop novel synthetic amphiphile formulations, which express a higher delivery efficiency and cell/tissue specificity. The next step will be applying the systems as developed in a comparative study that relies upon gene expression in vitro versus in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Power and the Past: European Empires and Archaeology in the Balkans, 1860s–1941' to be submitted under Horizon Europe.

assistant: **Abstract**

This project compares the archaeological research that scholars from Austria(-Hungary), Italy, France, and Germany conducted in the Balkan countries of Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Serbia, Albania, and Kosovo between the 1860s and 1941. During this period, the researchers' countries/empires were interested in the Balkans for various, and respectively specific, political, geostrategic, economic, financial, imperial, and colonial reasons. The project combines this transnational and global history with the history of archaeology in the Balkans as an often-neglected region and the so-called ""European Orient"". Principal research questions are (1) how archaeological interest in the Balkans emerged and developed in the four countries/empires, (2) how that archaeological interest was influenced by the respective government’s interests and policies in the region, and (3) how archaeologists viewed, and cooperated with, local researchers and inhabitants. The project will be hosted by the Institute of Culture Studies of the Austrian Academy of Sciences and, through a secondment, the Department of Archaeology of the University of Ljubljana. Sources are archaeological publications as well as archival materials of individual researchers and scientific and governmental institutions. Their interpretation will be supported by visualisations of the analysed research in maps. Findings are disseminated through, among other things, an international conference and a student workshop as well as, to non-academic audiences, a public exhibition. As a result, the project will contribute, among other things, to developing the history of archaeology into an autonomous, interdisciplinary, reflexive field, and to heightening the public's awareness that archaeology does not