RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PREVENTING AND DELAYING THE DEVELOPMENT OF DIABETES IN AFRICA: A RANDOMISED PLACEBO -CONTROLLED DOUBLE-BLIND PHASE III TRIAL OF METFORMIN IN HIV-INFECTED PERSONS WITH PRE-DIABETES' (2021-2027).

assistant: **Concept**

Diabetes is a common co-morbidity among people living with HIV. Since Oct 2021, we have been conducting a phase III randomised placebo-controlled trial of metformin among people living with HIV and pre-diabetes in Dar es Salaam, Tanzania (EDCTP RIA2018CO-2513). The aim is to test whether metformin can prevent progression to diabetes among people living with HIV. The primary endpoint is the time to diabetes.We had planned to enrol 2100 participants, follow-up for 3 years, and finish at the end of Dec 2024. COVID-19 resulted in severe delays to regulatory review. HIV care was decentralised away from health facilities to community posts to reduce COVID-19 risk, which led to much slower recruitment. We have now enrolled 1550 participants over the last 20 months. Less than 1% have been lost to follow-up. We will reach our target recruitment in Dec 2023 and will continue follow-up until Dec 2025. This will provide an average follow-up of 3 years per participant. Analyses of aggregated data to date show that glucose levels and weight have fallen over first 12 months among the trial cohort. Thus, we believe that trial will answer the research question by continuing follow-up until Dec 2025. In 2026, we will disseminate the findings to stakeholders and to the international bodies. We are collecting clinical, health economics, and qualitative data. The trial is being done as an equitable partnership between European and African researchers, and in partnership with Ministry of Health policy-makers and African patient representative bodies. We have good links with the African Centres for Disease Control, World Health Organisation (WHO-AFRO and Geneva offices), and Global Fund in order to inform policy considerations. Merck Pharma has provided medicinal products including the placeb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In-depth quantification and characterisation of PI 3-kinase signalling networks at a System Biology level' in the context of a Seventh Framework call.

assistant: **Objectives**

The group of genes termed phosphoinositide 3-kinase (PI3K for short) have roles in many important biological functions and are also implicated in diseases such as diabetes, inflammation, allergy and cancer. Therefore, there are many pharmaceutical and biotechnological companies interested in targeting this pathway. There are 8 different PI3K genes and it is becoming clear that they have different functions and are involved in different diseases. However, although the distinct biological roles of the different PI3K isoforms are being gradually elucidated, there is little information regarding how the different PI3Ks perform their unique biological functions. We will assess using a Systems Biology approach how the different PI3K genes differ in the way by which they affect downstream protein kinases by means of a novel method based on mass spectrometry. This technique is a phosphoproteomic approach that allows quantifying signalling at the system biological level and in an unlimited number of samples and replicates, thus enabling the quantification of protein kinase activation in a comprehensive and robust fashion. Since the technique is not limited by the availability of antibodies, it allows quantifying signalling without a preconception of which pathways may be affected by PI3K; i.e., at the system level. For this, we will inactivate specific isoforms of Class IA PI3K genes (p110α, p110β and p110δ) in cells by pharmacological and genetic means; comprehensive quantification of phosphorylation will then be carried out using quantitative mass spectrometry techniques available in the Host Laboratory. In addition to provide important insights into the biochemical mechanism of isoform specific PI3K signalling from a Systems Biology approach, this work may also lead to the di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'LightNet - Tracking the Coherent Light Path in Photosynthetic Networks' (LightNet) targeting Horizon 2020.

assistant: **Abstract**

ature has developed photosynthesis to power life. Networks of light harvesting antennas capture the sunlight to funnel the photonic energy towards reaction centres. Surprisingly, quantum coherences are observed in the energy transfer of photosynthetic complexes, even at room temperature.Does nature exploit quantum concepts? Does the coherence help to find an optimal path for robust or efficient transfer? How are the coherences sustained? What is their spatial extent in a real light-harvesting network? So far only solutions of complexes were studied, far from the natural network operation, putting on hold conclusions as to a biological role of the coherences.My group recently succeeded in the first detection of coherent oscillations of a single photo-synthetic complex at physiological conditions, and non-classical photon emission of individual complexes. These pioneering results, together with our expertise in nanophotonics, pave the way to address photosynthetic networks in real nano-space and on femtosecond timescale. Specific objectives are:--Ultrafast single protein detection: tracing the fs coherent energy transfer path of an individual complex; addressing the very nature of the persistent coherences.-Beyond fluorescence: light harvesting complex are designed for light transport, not emission. I will explore innovative alternatives: optical antennas to enhance quantum efficiency; detection of stimulated emission; and electrical read-out on graphene.-Nanoscale light transport: using local excitation and detection by nanoholes, nanoslits and scanning antenna probes I will spatially map the extent of the inter-complex transfer.-The network: combining both coherent fs excitation and localized nanoscale excitation/detection I will track the extent of coherences throughou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'BILISTICK: A low cost point-of-care for early diagnosis of hyperbilirubinemia in newborns' (BILISTICK), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the overall project is to lead to the international market “Bilistick”, an innovative low-cost Point-of-Care for early diagnosis of hyperbilirubinemia. The system aims to prevent, through early diagnosis, the permanent neurological damage that severe hyperbilirubinemia can cause in newborns.Every year in European Union there are about 3 thousands cases of kernicterus (worst consequence of hyperbilirubinemia) determining consequent huge costs for National Healthcare Systems. Kernicterus is a largely preventable disease if severe hyperbilirubinemia is identified early and promptly treated. For this reason AAP Guidelines (adopted by EU) recommend universal bilirubin screening and individualized post-discharge follow-up care based on results of such screening. However existing solutions are expensive, not portable or not enough accurate. Bilistick is the only in vitro rapid diagnostic device for measuring the level of bilirubin in the blood of newborns. It is low cost, minimally invasive, portable, giving rapid response, accurate and applicable in all newborns. It is the result of experience acquired during years of academic and professional research carried out by the entrepreneurial team of Bilimetrix s.r.l.. Bilimetrix s.r.l. is a spin-off of the University of Trieste, established as a research and development company. Its core business is development of medical devices based on advanced technologies oriented on liver, kidney and heart dis-functions. All solution are mainly based on new biomarkers. The purpose of the feasibility study is a comprehensive examination of all aspects of feasibility of the project, from the technical to the economical viewpoint, converging in a detailed business plan for application in Phase 2. Emphasis will be put on market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Native production of wnts as an example for cystine-rich proteins' under Fifth Framework.

assistant: **Concept**

The project aims to a principle solution for the native production of Wants as cosine-rich proteins. All promising strategies of recombinant expression are involved. The focused availability also provides these valuable proteins as tools for diagnostics, therapy and research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Technologies for road advanced cooperative knowledge sharing sensors'.

assistant: **Concept**

The problem of safety in transport is especially acute in the case of road networks. To confront this the EC has proposed to reduce by 50% the number of road fatalities by 2010. Nowadays, safety relies most of the time in autonomous or stand-alone systems, which offer without any doubt room for some improvements.In order to overcome the visible limitations of those systems, there is a need for another class of solution: Co-operative Transport Systems (CTS), whose intelligence is distributed/shared between road infrastructure and vehicles, compromising innovative approaches on transport safety and efficiency. To that end, TRACKSS has a strategic goal: enabling a breakthrough in the current systems for sensing and predicting flow, infrastructure and environmental conditions surrounding traffic, with a view to improve road transport operations safety and efficiency.The project will:- Improve and develop a number of breakthrough sensing technologies.- Develop a new model for knowledge sharing between sensors.- Use advanced data fusion techniques and a DSS to assess and predict safety and efficiency conditions of the transport network.- Develop an architecture and define an operational framework, ensuring the compatibility of the project results with the e-Safety overall architectures.- Validate the project results through 3 pilotsUndoubtedly, today available (or under development) technologies enable the improvement of not only sensing systems, but also the way these systems share information.The key idea to have mind when reading this proposal and the base and goal of TRACKSS is: Smarter systems demand smarter sensors; cooperative systems require cooperative sensors. And last but not least in order to ensure interoperable throughout the European road network and to achieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Between Social Values and Profitable Performance: The Case of B-Corporations' (BCorp) under Horizon 2020.

assistant: **Objectives**

How entrepreneurs could profit from social responsible investments? This issue implies a balance between entrepreneurs’ investments in profitable business models and their engagement in non-profit social actions. To address this question, the project studies the B-Corporations as a new legal business form of corporations (private and public) pursuing benefits for society and shareholders. A non-profit certifying organization, B-Lab, analyses the impact of these companies on society, with particular attention to their ability to provide to ‘communities’ beneficial products or services. Although first established in US, now they are present in 34 countries across 121 industries. Employing this legal form of social companies, the proposal exploits the notion of community-focused strategies (CFS) to refer to the actions that entrepreneurs should pursue to establish links with communities to fulfill reciprocal social values. If people join communities to satisfy their identity needs, entrepreneurs might seek to align their ventures’ strategy to them to improve entrepreneurial performance. Building on social identity theory, entrepreneurial and strategy research, this project adopt mainly a demand-oriented approach. First, it tries to explain differences in new ventures’ performance investigating how B-Corps interact with their communities and through them access customers’ information and gaining loyalty. Second, it explores and profiles the B-Corps as new examples of social entrepreneurial ventures. Finally, it studies entrepreneurs’ strategies to develop long-term interactions with the communities. The statistical evidence is drawn from secondary data, surveys to entrepreneurs, and lab experiments. Implications on ventures’ success rate, growth and drawbacks of the interpl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'WISER – the energy saving and burglar proof window that breathes for enhanced indoor comfort' (WISER).

assistant: **Concept**

BGTEC is a Polish SME, active since 1996 in the production of customised windows and fenestration products for high-end clients; our current niche market consists of new constructions and deep retrofitting projects, in particular nearly zero energy single-family houses, villas and passive houses. As a result of our continuous product development efforts to fulfil market demand, in 2012 we have conceived an innovative idea for a reversible window technology, the WISER window. Windows operated through a rotation across mid axis are state of the art, however none of them allows users to rotate the window sash 180° and lock it in the new position. WISER reversible window technology is enabled by innovative hydraulic gaskets and burglar-proof electro-magnetic locking mechanisms fully integrated in the structure of the frame, operated via a simple to use control system which can be integrated to a central building automation infrastructure or central security system. WISER is the only window that can reduce the thermal radiation from the outside during summer season, and reduce the thermal dispersion from the interior in the winter, thanks to the double positioning of the low-E glass. Enhanced ventilation is permitted through an innovative use of the active gaskets, permitting air flow while keeping the window locked. WISER window can be easily adapted to different climates and seasons along the year as well as material combinations and building types. WISER allow easy, cheaper and safer cleaning of glasses on both sides. WISER product family is aimed to change the way people interacts with windows: its unique design satisfies in a single product the needs for energy efficiency, indoor climate, security as well as easier and safer cleaning. It represents therefore an incredib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of improved sofc components by optimizing the microstructure'.

assistant: **Concept**

Solid Oxide Fuel Cells (SOFCs) are currently being developed because of the superiority of this energy conversion device regarding high efficiency and low pollution. The components of an SOFC are the electrolyte (ZrO2+8%mol Y203 = YSZ), the anode (Ni+YSZ), the cathode (LaMnO3) and the interconnector (LaCrO3 or Cr-basis alloy). In order to operate this device properly, the fuel electrode (anode) has to be primarily optimized with respect to porosity and the gas permeability. These two parameters can be influenced by the design and the processing route of this component. Our aim is to develop the microstructure of the anode by modifying the production procedure. For every modification we have to appropriately measure and characterize the relevant parameters and control the operational ability not only of this component, but also of the whole system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Architecture-driven, Multi-concern and Seamless Assurance and Certification of Cyber-Physical Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Embedded systems have significantly increased in technical complexity towards open, interconnected systems. This has exacerbated the problem of ensuring dependability in the presence of human, environmental and technological risks. The rise of complex Cyber-Physical Systems (CPS) has led to many initiatives to promote reuse and automation of labor-intensive activities. Two large-scale projects are OPENCOSS and SafeCer, which dealt with assurance and certification of software-intensive critical systems using incremental and model-based approaches. OPENCOSS defined a Common Certification Language (CCL), unifying concepts from different industries to build a harmonized approach to reduce time and cost overheads, via facilitating the reuse of certification assets. SafeCer developed safety-oriented process lines, a component model, contract-based verification techniques, and process/product-based model-driven safety certification for compositional development and certification of CPSs.AMASS will create and consolidate a de-facto European-wide assurance and certification open tool platform, ecosystem and self-sustainable community spanning the largest CPS vertical markets. We will start by combining and evolving the OPENCOSS and SafeCer technological solutions towards end-user validated tools, and will enhance and perform further research into new areas not covered by those projects. The ultimate aim is to lower certification costs in face of rapidly changing product features and market needs. This will be achieved by establishing a novel holistic and reuse-oriented approach for architecture-driven assurance (fully compatible with standards e.g. AUTOSAR and IMA), multi-concern assurance (compliance demonstration, impact analyses, and compositional assurance of security and sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cold Atmospheric Molecules on a Chip' in the context of a Horizon 2020 call.

assistant: **Objectives**

Highly excited electronic states of small atmospheric molecules play an important, but as yet little explored, role in the reactivity, and in the evolution of plasmas, including the Aurora Borealis, in the upper atmosphere of the Earth. Processes involving these highly excited states are very challenging to investigate theoretically because of the high density of states close to the ionization limits where they lie. Therefore, experimental input is essential for the identification of the reaction and decay mechanisms, and the quantum states of importance in future studies. However, experimental techniques that can be exploited to provide this input have only become available very recently. These techniques permit gas-phase molecular samples in these highly excited states to be confined in traps for sufficient lengths of time (e.g. 1 ms – 10 ms) for detailed studies to be performed in a controlled laboratory environment. They include resonance-enhanced and non-resonance-enhanced multiphoton excitation of long-lived high angular momentum Rydberg states of small molecules, and chip-based devices for efficiently decelerating, transporting and trapping these samples.With the support of this Consolidator Grant a new experimental research program will be developed in the Department of Physics and Astronomy at University College London involving laboratory based studies of (1) inelastic scattering processes, and (2) the decay mechanisms of gas-phase atmospheric molecules, including N2, O2 and NO, and their constituent atoms, in high Rydberg states. The planned experiments will be directed toward understanding the effects of static and time-dependent electric and magnetic fields, and blackbody radiation fields on slow dissociation processes that occur in highly excited states of