RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Roll-to-roll PAper Sensors'.

assistant: **Objectives**

ROPAS aims to develop a wireless sensor device on a paper surface which can be manufactured using high-end and low-cost printing techniques.A technological platform is created on a fiber based substrate consisting of the following building blocks: 1. a planar printed battery, 2. a (wireless) signaling device, and 3. a printed sensor switch. Hereto, recent advantages in nanotechnology ((encapsulation) printing, surface modification of fiber based products, sensor and battery development), biotechnology (enzyme encapsulation) and ICT (wireless communication) are integrated on paper.The technological platform can be used to create various high impact (security) applications, which are demonstrated in security tags and smart labels for anti counterfeiting purposes to integrate displays in paper and smart track and trace envelopes. ROPAS will demonstrate products which give the consumer the benefit of saving time and giving more information about the package than possible today, at a low additional cost. Simultaneously creating new products and virgin businesses to boost the paper and pulp industry.The project results in: design guidelines for the technological platform, the creation of printable sensor materials, and processes for printing of such materials including conditioning of the paper substrates.The consortium is carefully constructed based on:1. Technologically advanced SMEs: Enfucell (printed battery), and MPicoSys(system architecture), who both received awards for there innovative strength and S2 Grupo (ICT security);2. SMEs and companies with high potential to market and exploit ROPAS technology: Starcke (security tags), Velpa (smart labels) and ELEP (smart envelopes), Loginle (security shipping) and Oce (printed intelligence);3. High impact RTDs: TNO (sensor de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative ligands for nuclear receptors to eradicate cancer relapse.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The aim of the “eRaDicate” international, multidisciplinary, and intersectoral cancer drug research and development programme is to empower 10 young scientists to become specialists in cancer research and drug development, while developing new therapies against cancer stem cell-driven relapse and metastasis. Nuclear receptors, such as retinoic acid receptor (RAR) and vitamin D receptor (VDR), play key roles in many hallmarks of cancer and constitute effective targets for modern cancer therapy. To address the EU priority “Mission Cancer”, we will 1) test the anti-cancer activity of RAR and VDR targeting compounds; 2) design and synthesise a highly innovative dual action hybrid compound acting simultaneously as RARγ antagonist and VDR agonist; 3) devise pre-formulation strategies for our compounds; 4) and develop a novel, deep learning-based cancer analysis and diagnostics method. We will test how our RAR and VDR-targeting compounds affect stemness and metastatic potential in leukaemia, breast, prostate, colorectal, and ovarian cancer. In parallel, we will assess if the pan-RAR antagonist is effective against chemotherapy-induced neutropenia. For the development of the RAR and VDR targeting compounds into administrable medicines, ready for eventual commercialisation, we will develop pre-formulation strategies. We will generate a novel and highly innovative label-free image analysis method based on histoplasmonic cytometry. The project will have lasting scientific, economic, and societal impact.In order to be prepared for a wide spectrum of career opportunities, we will train the doctoral candidates (DCs) not only to perform original and independent research on an internationally competitive level, but also endow them with creative, critical and entrepreneurial mindset, co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Energy efficient & Cost competitive retrofitting solutions for Shopping buildings' under Seventh Framework.

assistant: **Concept**

EcoShopping project aims to build a holistic retrofitting solution for commercial buildings to reduce primary energy consumption down to less than 80kWh/m2 per year and increase the share of RES (Renewable Energy Sources) more than 50% compared to the state of the art. The approach will be systemic by developing (1). Novel thermal insulation solutions using cost effective materials to further reduce the thermal losses and lower the energy consumption. (2). Easy to install and cascadable daylighting technologies based on the NLIS system to reduce energy billing and improve comfort. (3). HVAC Retrofitting systemic approach based on RES direct powered DC variable speed heat pump and harnessing the Building Thermal Mass for reducing the energy consumption. (4). Integrated solution way based on the Intelligent Automation Unit (IAU) concept and Mobile Robot.The project intends to use and integrate available products and technologies along with a network of low-cost equipment to accurately monitor the environmental and occupancy parameters to have a better control of the BAM and full exploitation of the Building Thermal Mass, which serves as a “Thermal Battery” and stores the RES directly without using battery, tank or other expensive storage material and simplifying the system structure. The purpose is to reduce the energy consumption  without losing comfort for users and providing, at the same time, higher energy performance, security and healthy, automatic and reliable services to visitors, building operators and owners. For this the development of the IAU and the extension of Mobile Robot plays an important role, in concept of accurate control, demand reduction, user oriented and friendly service, building security etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Green chemistry and biotechnology approaches for the development of nature-based cosmetics'.

assistant: **Concept**

GreenCosmIn aims to form a tight multisectoral and interdisciplinary network for the implementation of green approaches for natural resources exploration and exploitation, towards the production of cosmetics. Extraction, advanced phytochemical analysis and dereplication, in vitro screening, and biotechnological production technologies will be applied in the development of natural cosmetic ingredients and their incorporation into final products. GreenCosmIn will use the prior knowledge of the consortium in biodiversity exploitation and green chemistry extraction with innovative extraction media in lab and pilot scale, for the discovery of extracts and compounds with bioactivity related to skin cosmetic properties (antioxidant, anti-hyperpigmentation, anti-ageing, anti-inflammatory, emollient, antimicrobial, prebiotic), and safety to humans and the environment. Biotechnology approaches and microorganism assisted methodologies will be applied to produce active compounds both in lab and large scale. Active ingredients will be incorporated into final products with preformulation studies and LCA/consumer satisfaction analyses will be performed. A balanced consortium of six Academic partners in the field of natural products chemistry, biodiversity, biotechnology, cosmetology, and biology, will efficiently interact with five Non-Academic partners in the field of metabolomics, biotechnology, cosmetics, and natural ingredients development. Among them, three Associated partners from biodiversity hot spots, ensure the collaboration towards innovative results, and secondments of researchers meaningful for their career and skill development, and the foundation of strong collaborations to be retained after completion of the project. Finally, GreenCosmIn will provide training and trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy technology dynamics and advanced energy system modelling' (1994-1998).

assistant: **Innovation**

The main objective of the project is to analyse energy technology and accompanying policy of the European Union by using advanced energy system models emphasising on technology evolution dynamics. The project aims at providing new insights for the EU energy and RTD strategy in the perspective of climate change and acidification targets. It will focus on the interactions between policy instruments and technology evolution, in the presence of growing market competition and uncertainty. In its scope, the project mainly considers the EU policy dimension (with special emphasis on burdensharing implications across countries and on the global position of the EU), but fully includes a world dimension, as well. Within its research component, the project intends to fully specify, and develop in all models involved, a common methodology for endogenous energy technology evolution mechanisms. The project involves PRIMES that formulates energy market competition in the EU covering all memberstates, MARKAL for selected countries that operates under the global system optimisation hypothesis, the world-wide MESSAGE modelling system (which has already experimented with endogenous learning by doing mechanisms) and POLES simulating the operation of energy markets across the world regions. A horizontal role is also envisaged for the SAFIRE model, regarding micro-simulation of new energy technology diffusion. The involvement in the project of all the major energy models that exist in Europe emphasises the importance given to the objectives of the project, but also serves for two other purposes: first, it allows for economies of scale in the research (modelling and data) regarding the innovative work on endogenising technology dynamics; second, it allows for comparisons and synergy, as the mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Brain-specific gene expression' in the context of a Fourth Framework call.

assistant: **Objectives**

A large number of cell types are found in the vertebrate brain but there is little understanding of how this diversity is controlled at the genetic level. To identify regulatory factors that govern neuronal phenotype, we wish to utilise as a starting point a gene whose expression is characteristic of a particular neuronal cell type. The gene encoding the a6 subunit of GABAA receptors serves as a unique marker for differentiated cerebellar granule cells. No expression is found in other brain regions, or in peripheral tissues. My research plan centres around defining the DNA regulatory regions (enhancers/silencers) of the a6 subunit gene using transgenic mice, and mapping DNase I hypersensitive sites. The transcription factors that act on these sites could turn out to be of general importance, and may direct cellular differentiation in a variety of neuronal tissues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Steroid glucuronides; development of liquid chromatography/mass spectrometric lc/ms analysis in the detection of doping in sport (SGLC/MS)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The wide use of doping substances is a growing problem in sport. The existing methods for anabolic steroids (AAS) are indirect, complicated, slow, quite expensive and include several possible sources of errors. The development of reference material as AAS conjugates and development of LC/MS method to detect them is needed. The collaboration between laboratories is necessary since the knowledge is not found in one laboratory. The synthesis and characterization of the reference materials will be finished in 2 years. Excretion studies and characterization of isolated glucuronide metabolites will start immediately after the synthesis is ready. The development of LC/MS methods and their validation and comparison to those already in practice will be performed by the end of 3rd year. The reference materials and the methods will be tested in doping control laboratories in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Automatic System for Peptide Synthesis' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The main aim of this project programme is represented by the design, the assembly and the test phases of an original system for the automated solid-phase synthesis of biopolymers, eg. petides and proteins. In line with market demands, the synthesise will be designed in order to carry out optimised chain assembly utilising the most widely used chemical strategies, i.e. both t-Boc and Fmoc chemistry. The synthesiser will be operated under computer control through dedicated software that will permit the operator not only to select a specific procedure from a range of different pre-programmed synthetic routes, but also to assemble personalised new ones: thus, the distinctive feature of the apparatus will be its extreme flexibility that will allow an easy up scaling of the process. A further original feature of the apparatus will be its plumbing scheme, which will be designed to facilitate optimization of the process from an engineering point of view: the presence of two reaction vessels (reactor and activator) set in separate hydraulic loops and served by two different pumps with independent delivery lines, will enable different chemical operations to be carried out at the sale time, thus, the total time required for each synthetic cycle will be dramatically reduced. The final goal of this project will be represented by the assembly of suitable devices to monitor the extent of the key reactions of solid phase synthesis process and the formulation of appropriate algorithms to control the entire synthetic process automatically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Virtual Proximity and Collaboration' to be submitted under Horizon 2020.

assistant: **Abstract**

This research program aims to enhance understanding of the effects of virtual proximity on knowledge spillover, by studying how distant researchers interacting together virtually at an online event affects subsequent knowledge co-production and diffusion, respectively using collaborative publication and citation behaviour as proxies. Similar to physical proximity that relies on face-to-face interactions between individuals to establish potential collaborative links, virtual conferences attempt to create a virtual sense of spatial proximity. Thus, this proposal introduces a new dimension of proximity – virtual proximity. Although it lacks the direct connections to other attendees afforded by physical conferences, virtual proximity is defined as a setting where individuals can still interact together virtually on a common topic of interest. A hybrid research methodology is used for the project, with one part consisting of quantitative analysis using primarily archival data, and the second part consisting of qualitative interviews to not only substantiate the quantitative results but also to better understand the underlying mechanisms. To mitigate endogeneity issues, I will use a difference-in-differences model to contrast a sample of researchers who participated in virtual conferences to a matched sample of qualitatively similar sample of researchers – in terms of research area, prior productivity, prior citations and experience – who did not attend, before and after the virtual meeting.Given path dependence of research, the finding of positive relationships would imply that over time the cumulative effect on knowledge spillover from virtual proximity has a significant impact in steering the research path of participants. Moreover, the results would also suggest that even
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biochemical and crystallographic studies on u2snrnp of the pre-mrna splicingmachinery', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Gene expression is regulated through transcriptional control, RNA processing, transport and localization rf RNA and translational control. A central element in this control system is the pre-mRNA splicing reaction mediated by a large RNA-protein complex called spliceosome. The aim of my PhD project will be to gain a more detailed insight into the structural organisation of snRNPs in order to understand the catalytic mechanism of pre-mRNA splicing at a molecular level. The project will be focused on U2 snRNP which is involved in branch site recognition. I will reassemble the U2 12S snRNP particle and parts thereof from overexpressed protein subunits and different RNA constructs for the biochemical characterisation and crystallographic analyses. The project is concerned with specific protein-protein and protein-RNA interactions within snRNPs, about how snRNPs achieve specific recognition of short RNA sequences within pre-mRNA and about interactions within snRNPs upon assembly into the entire spliceosome. Besides the information about this important biological process, general ideas about protein-protein and protein-RNA interaction are expected to evolve. Training content (objective, benefit and expected impact) The project offers a wide variety of different techniques ranging from molecular biolgy and protein biochemistry to structure determination, especially a profound training in xray crystallography. It also provides a deep theoretical knowledge about protein and RNA structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Red teaming the H0 Tension' under Horizon Europe.

assistant: **Concept**

Despite the spectacular success of the standard cosmological model over the past two decades, recent observations from large sky surveys and distance measurements with a broad range of cosmological probes suggest cracks to the accepted paradigm: differences now appear in measurements of quantities the current cosmological model predicts as equal. These are called “tensions”. The most important tension concerns the Hubble parameter, H0, which quantifies the expansion rate of the Universe now, some 13 billion years after Big-Bang. The Hubble tension is the discrepancy between the value of H0, when inferred as a global parameter of the standard cosmological model relying heavily on early-Universe physics, and when measured directly in the late-time Universe from the redshift-to-distance relation. While the tension is well-established, there is no consensus on its actual significance nor on what it means for the standard cosmological model, even broadly speaking. Comparing the values of H0 from the early and the late Universe is like “Threading a needle from the other side of the Universe”; in a very unique way it enables vital end-to-end tests of cosmology to be performed. RedH0T proposes to determine, in a self-consistent manner and using the synergies between all available cosmological probes, whether the tension arises from observational issues or from limitations in the current cosmological model. In the former case, we will impose strong limits of possible deviations from the standard cosmological. But if the latter is confirmed, it will represent one of the most significant discoveries of the 21st century, with profound implications not only for cosmology, but also for physics in general. The team gathers all required expertise to tackle the problem from all view-ang