RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving horizontal activities in project execution: project management, configuration management and change management' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Due to the growing complexity of projects, keeping control of critical project parameters like effort, cost and time is increasingly difficult. In many cases, this results in late completion of projects and exceeded budget and effort leading to significant commercial loses both for the provider and the supplier. This is a common business concern and the main driver for this experiment whose objective is meeting customer requirements in terms of: timely delivery, costs as agreed and product as required.THE EXPERIMENTThe achievement of the objective above requires the improvement of project management practices and the implementation of methods and tools as follows:a) Project management. Notably, project planning and monitoring of critical parameters (effort, time, costs) using Microsoft Project and Excel.b) Configuration management using PVCS.c) Change request management using ChangeFlow.b) and c) are of particular interest to PRO DV as they commercialise customised systems based on different versions of several components. This implies a careful management and control of the configuration of the client application developed and the changes requested.The experiment will be performed around IRIS (geographical information system developed by PRO DV and delivered to clients after customisation). Two IRIS applications will be compared (a power supply application will use new methods and tools while a gas application will use conventional ones).PRO DV employs 80 people, 26 of them are involved in the IRIS team.EXPECTED IMPACT AND EXPERIENCEPRO DV expects to gain know-how on keeping projects in line with planned effort, time and cost; improved estimation and planning of future projects and reliable managing of software documents as well as fast handling of change requests. A c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Delta of Language', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Mental life fluctuates, changing from moment to moment as the incessant and turbulent flow of thought rages. In 3% of the worlds population, the fragile equilibrium that we all hope to maintain gives way to dynamical changes resulting in psychotic episodes, which after remission tend to recur over time. A capacity to predict them at a clinically relevant temporal resolution, similar to our capacity to forecast a thunderstorm, would be a major advance in public health, with the important difference that, unlike thunderstorms, psychosis can be prevented. We test a previously untested and untestable hypothesis: that meaning encoded in spontaneous speech, translated into digitalized quantitative features, computationally analyzed with natural language processing (NLP) tools, can serve as a key personalized and interpretable predictor of phase transitions from remission to psychotic relapse. Addressing this hypothesis requires conceptual and methodological breakthroughs in our understanding of language and what signals its variability can carry for a pathophysiological process. We pursue these with a synergetic combination of linguistic, neuroimaging, psychiatric, and e-health insights. Using a hypothesis-driven approach we will (i) define generalizable language metrics relating to symptom variability cross-sectionally; (ii) identify individually-specific neural signatures of psychosis and remission related to changes in these linguistic metrics, using a dense-sampling approach; (iii) test the metrics retrospectively as predictors of relapse in an independent longitudinal cohort; and (iv) take the paradigm from the lab to the patients home in a prospective clinical study testing whether we can predict state change before it is catastrophic, at the temporal resolutions clinic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How does the brain code time?' in the context of a Horizon 2020 call.

assistant: **Objectives**

Time underlies each and every activity and perception. And yet our knowledge about time perception remains limited. It is hindered by a division between psychological and behavioral findings on the one hand, and neuroscience findings on the other hand. The former rarely address biological constraints, while the latter rarely informs a unified theory for timing. Theories on time perception have centred on the modular nature of time perception. Is time sensed through the operation of central mechanisms serving all sensory and motor systems? Or is time sensed locally, within different sensory and motor systems? TIMECODE entertains a third possibility for time perception in the brain and overcomes the gap between psychological theories and physiological manifestations of time by assuming a hierarchy of time that entails both a local level of analysis and a domain-general level of analysis. I identify three dimensions that need to be investigated in order to substantiate this possibility. First, local representations of time need to be identified within sensory (and motor) systems. Second, network dynamics that support the propagation of such representations need to be investigated. Brain rhythms play an important role in both local and inter-areal computations. Thus, the role of brain rhythms will be assessed for both levels of analysis. Finally, a brain-wide assessment of selectivity to time needs to be explored. TIMECODE investigates the initial local code for time, global code for time, and the inter-areal dynamics between them by combining human physiology (invasive and non-invasive) with illusions of time perception (in behavior). It investigates brain-wide selectivity to time by applying computational tools to intracranial data from human and non-human primates. Combi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Validation and verification of SIMMER code model for Lead-lithium water and non-condensable gases chemical interaction'.

assistant: **Objectives**

The main objectives of VALIDATIO are to first characterize the chemical reactions of Lead-Lithium, water, and non-condensable gases, under conditions similar to those expected for the European water cooled lead lithium (WCLL) breeding blanket (BB) under accident conditions and the creation of an experimental database for SIMMER code validation by performing series of experiments at the existing experimental facility LIFUS5/Mod3 (Brasimone, Italy)  (this  part of the work is very challenging since reaction characteristics of Lead-Lithium, water and non-condensable is highly sensitive to thermo-dynamic conditions of the environment (pressure, temperature, velocity etc.)) and based on obtained experimental data perform the verification and validation of  SIMMER code, modification in code for irregularities found in the validation process and perform the safety analysis of WCLL-BB.The problem is very challenging since the available experimental data for code validation is extremely limited. Only very little useful information is available in the literature; therefore, a dedicated experimental campaign is always highly advantageous for code validation and verification under the accident scenario. This issue is also complicated since the interaction of fluids results in multi-component, multi-phase flow, which is very hard to model. I intend to perform a series of experiments on Lead-Lithium, water, and non-condensable chemical interaction (which I will design to accommodate for all the possible sample conditions that may encounter under WCLL-BB under different accident conditions) at the experimental facility, LIFUS5/Mod3 to obtain the database and to experimentally characterize the process. The obtained database will be utilized for the validation, verification, and modific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Metal-Organic REagents for Light-Enabled Shuttling of protons and electrons' in the context of a Horizon Europe call.

assistant: **Objectives**

Protons and electrons are the currency of energy conversion and play a key role in some of the most transformative technologies such as the reduction of N2, CO or CO2.  Exploiting water and sunlight as renewable resources for these transformations offers a means for solar-to-chemicals conversion. Thus, our ability to control the transfer of protons and electrons preventing the more favourable formation of H2 poses an exciting fundamental problem.Strategies based on proton coupled electron transfer (PCET) have demonstrated key benefits by providing low energy pathways that bypass the most energetic, charged intermediates. However, important problems remain regarding the development of PCET shuttles that: (1) behave as catalysts harnessing water and light, (2) promote multi PCET to avoid unstable radical intermediates that undermine the selectivity and efficiency, and (3) can be integrated in complex multielectron/multiproton transformations relevant to solar energy conversion such as N2 reduction.I will address these problems by designing metal-organic PCET shuttles that target three specific objectives: (1) to merge light and electricity for reductive PCET in a novel photoelectrocatalytic strategy using molecular shuttles that exploit counter oxidation reactions of practical relevance, (2) to achieve an unprecedented control over multi PCET to impact the selectivity of reductive transformations via the colocalization of redox and acid/base sites within coordination cages, and (3) to integrate photo(electro)catalytic PCET in small molecule catalysis with new tandem approaches towards the reduction of N2 using light and water.Overall, these objectives will provide unconventional tools to affect the mechanisms of reductive reactions. Besides transgressing the frontiers of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bioengineering prediction of three-dimensional vascular growth and remodeling in embryonic great-vessel development' under Seventh Framework.

assistant: **Concept**

Globally 1 in 100 children are born with significant congenital heart defects (CHD), representing either new genetic mutations or epigenetic insults that alter cardiac morphogenesis in utero. Embryonic CV systems dynamically regulate structure and function over very short time periods throughout morphogenesis and that biomechanical loading conditions within the heart and great-vessels alter morphogenesis and gene expression. This proposal has structured around a common goal of developing a comprehensive and predictive understanding of the biomechanics and regulation of great-vessel development and its plasticity in response to clinically relevant epigenetic changes in loading conditions.  Biomechanical regulation of vascular morphogenesis, including potential aortic arch (AA) reversibility or plasticity after epigenetic events relevant to human CHD are investigated using multimodal experiments in the chick embryo that investigate normal AA growth and remodeling, microsurgical instrumentation that alter ventricular and vascular blood flow loading during critical periods in AA morphogenesis. WP 1 establishes our novel optimization framework, incorporates basic input/output in vivo data sets, and validates. In WP 2 and 3 the numerical models for perturbed biomechanical environment and incorporate new objective functions that have in vivo structural data inputs and predict changes in structure and function. WP 4 incorporates candidate genes and pathways during normal and experimentally altered AA morphogenesis. This proposal develops and validates the first in vivo morphomechanics-integrated three-dimensional mathematical models of AA growth and remodeling that can predict normal growth patterns and abnormal vascular adaptations common in CHD. Multidisciplinary application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Revealing the role of intrinsically disordered proteins in transcription and replication of measles and sendai paramyxoviruses using nuclear magnetic resonance spectroscopy' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Over the last decade it has become increasingly clear that a large fraction (up to 40%) of the proteins encoded by the human genome are disordered. Intrinsically disordered proteins (IDPs) remain functional despite a lack of a well-defined structure, such that the classical structure-function paradigm breaks down, and new insight into the relationship between primary sequence and molecular function is necessary. The object of this proposal is to study the role of IDPs in the replication and transcription of Measles (MeV) and Sendai viruses (SeV). Replication and transcription of the viral RNA in these related paramyxoviridiae is initiated by an interaction between the intrinsically disordered C-terminal domain, NTAIL, of the nucleoprotein and the highly flexible C-terminal domain, PX, of the phosphoprotein. Upon binding to PX, both NTAIL proteins undergo alpha-helical folding of the molecular recognition element, positioned at the C-terminal end of the unfolded domain of the nucleoprotein. To fully understand the molecular basis of this interaction, and to determine the role of the disordered domains, atomic resolution models of the proteins are necessary in their free, pre-recognition states and in complex with their partner proteins. In order to achieve this aim I will use high field solution state NMR, small angle neutron and X-ray scattering and molecular modeling. Due to its inherent flexibility solution state NMR studies of the NTAIL domain will also be performed in the context of the entire 13C/15N labeled nucleocapsid (particles whose size ranges from 10-500MD). These particles will be further studied using solid state NMR and electron microscopy. This system represents a paradigm of intermolecular interaction involving highly flexible proteins and will therefor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hedging under Friction and Uncertainty: Theory and Numerics' under Seventh Framework.

assistant: **Concept**

In this project our goal is to deal with a class of hedging and pricing problems whicharise in modern Mathematical Finance.These problems are not only interesting fromthe applications point of viewbut also provide a good source for new mathematical questions which requirenew tools in the area of probability theory.We will focus on three main topics:(i) Hedging with Friction.(ii) Robust Hedging.(iii) Numerical Schemes.All the above topics are related to the theory ofpricing and hedging of derivative securities.In the last 35 years there was great progress in this direction.By now there is quite a good understanding of pricing and hedgingin frictionless financial markets with a known probabilistic structure.This understanding was achieved by developing the machinery of stochastic calculus,stochastic control, martingale theory,hypothesis testing, etc.In real market conditions,it is very difficult to providea correct probabilistic model for the behaviorof stock prices.Furthermore, trading of assets is subject to transaction costs,i.e. there is a gap between an ask price and the bid price.These two factsraise the natural questionof understanding hedging in markets with friction and model uncertainty.Usually, when dealing with complex models of financial markets, explicitformulas for option prices and the corresponding super--replication strategiesare not available. This is the motivation to study numerical schemesfor several stochastic control problems which are related to hedging under volatility uncertainty.In the current project we are interested not only in providing the algorithms of numerical schemes,but also in implementing them.In summary,the proposed questions are not only crucial for the understandingof pricing andhedging in financial markets, but also a great sour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Positive Entrepreneurship' (PosEnt).

assistant: **Innovation**

The goal of Positive Entrepreneurship (PosEnt) is to train a talented researcher through a research project focused on a novel application of positive psychology in the field of entrepreneurship. The project will investigate signature strengths, positive emotions, thriving, resilience and eudaimonic well-being (WB) of entrepreneurs and their families. This multidisciplinary project will help to open a new direction of Positive Entrepreneurship research and will have an impact on science and business practice in Europe. To date the WB of entrepreneurs and their families has received only limited attention and research is: (1) rather static, (2) focused on entrepreneur-employee comparisons, (3) informed by relatively ‘old theories’ about drivers of WB of employees, (4) focused on subjective WB. What is missing is a more interactive/collective, process-oriented view that considers processes related to eudaimonic WB and thriving.The fellow – Dr. Przemysław Zbierowski, will be trained in a number of skills (concerning research, publication, dissemination and transfer of knowledge) that have been identified by him as insufficiently developed to advance his career and to achieve (1) maturity which will be reflected in professorship in home country and (2) potential to lead research teams across Europe. At the host institution – Aston University and during the secondments, the applicant will have access to unique training experience, outstanding researchers, including the supervisor – Prof. Ute Stephan, with diverse backgrounds from psychology, economics, and geography to entrepreneurship.The PosEnt output will be relevant for European science base and economic and social life. The outputs will contribute to the enhancement of EU scientific excellence by opening the innovative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interaction Dynamics of Bacterial Biofilms with Bacteriophages' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Biofilms are antibiotic-resistant, sessile bacterial communities that occupy most moist surfaces on Earth and represent a major mode of bacterial life. Another common feature of bacterial life is exposure to viral parasites (termed phages), which are a dominant force in bacterial population control throughout nature. Surprisingly, almost nothing is known about the interactions between biofilm-dwelling bacteria and phages. This proposal is designed to fill this gap using a combination of novel methodology, experimental systems, and mathematical modeling. We have recently developed a new microscopic imaging technique that allows us to image and track all individual cells and their gene expression inside biofilms. First, we will use this technique for tracking the population dynamics of bacteria and phages within biofilms at single cell resolution. By genetically manipulating bacterial hosts and their phages, and by varying environmental conditions, we will investigate the fundamental biological and physical determinants of phage spread within biofilm communities. Second, we will study how biofilms respond to phage attack on both intra-generational and evolutionary time scales, focusing in particular on proximate response mechanisms and the population dynamics of phage-resistant and phage-susceptible cells as a function of biofilm spatial structure. Lastly, we will combine our novel insights to engineer phages that manipulate the composition of biofilm communities, either by subtraction of particular bacterial species or by addition of novel phenotypes to existing biofilm community members. Altogether, the proposed research promises to uncover the major mechanistic and evolutionary elements of biofilm-phage interactions. This combined work will greatly enrich our knowledge