RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elucidating the role of macroH2A1.2 histone variant as a metabolic sensor in the epigenetic regulation of leukaemia cell fate.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The initiation and maintenance of leukaemia are often regulated through the interaction of epigenetic mechanisms and metabolism, but how these affect each other, is not always fully understood. One of the epigenetic mechanisms that alter cell fate is the replacement of replication-coupled histones with non-canonical variants. MacroH2A (mH2A) variants (mH2A1.1, mH2A1.2 and mH2A2) have a large, metabolite-binding macrodomain and differ from each other solely in the structure of their ligand-binding pocket. Of those three, only mH2A1.1 has known ligands, while the binding partner and corresponding biological functions of mH2A1.2, are still unknown.The preliminary data suggest phospholipid molecules as unique ligands of mH2A1.2. At the same time, they show that the MACROH2A1 is required for the maintenance of the stemness of leukaemia stem cells and leukaemia itself. During the ChroMet project, by using cutting-edge techniques in cell and molecular biology, computational biology and biochemistry, I aim i) to confirm the identity of putative ligands of mH2A1.2 and to biophysically characterize the binding interaction, and ii) to test the contribution of the newly identified metabolite-binding capacity of mH2A1.2 on the leukemia cell differentiation and tumorigenicity. The findings of the project will allow me to describe the mH2A1.2 as an entirely novel metabolic sensor on chromatin, which, through the binding of phospholipid ligands, regulates cell metabolism and impacts leukaemia cell fate.The complementary knowledge and expertise of the hosting group (in epigenetics and metabolism), the hosting institute and long-standing collaborators (in leukemia research), and my own (in biochemical analyses of protein-ligand interactions) will ensure the successful realization of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart Distribution Grid: a Market Driven Approach for the Next Generation of Advanced Operation Models and Services' (DOMINOES), addressing dissemination and exploitation.

assistant: **Impact**

The DOMINOES project aims to enable the discovery and development of new demand response, aggregation, grid management and peer-to-peer trading services by designing, developing and validating a transparent and scalable local energy market solution. The market can be leveraged to share local value, increase renewable energy accessibility and make better use of local grids by Distribution System Operators (DSO), Prosumers/Consumers, Energy Retailers and other key stakeholders. The project will show how DSOs can dynamically and actively manage grid balance in the emerging future where microgrids, ultra-distributed generation and energy independent communities will be prevalent. Best value will only emerge if these resources and stakeholders can be connected to both DSO activities and the centralized market mechanism. The project will establish solutions for this challenge by addressing the following steps:1. Design and develop a local energy market architecture2. Develop and demonstrate ICT components enabling the local market concept 3. Develop and demonstrate balancing and demand response services supporting the local markets 4. Design and validate local market enabled business models5. Analyze and develop solutions for secure data handling related to local market enabled transactionsWith these steps, the DOMINOES project is able to address all the requirements of the LCE-01-2017 call. The project will deliver 1. new business models for demand response and virtual power plant (VPP) operations; 2. tools and technology validation for demand response services; 3. services based on smart metering; 4. methods to utilize VPPs and microgrids as active balancing assets; 5. secure data handling procedures in local markets. These results will be validated in three validation site
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flexible and advanced Biofuel technology through an innovative microwave pYrolysis & hydrogen-free hydrodeoxygenation process', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Biomass-derived liquid transportation fuels have been proposed as part of the solution to mitigate climate change and many countries are providing incentives to support the growth of bioenergy utilization. Nevertheless, most biofuels currently are made from food-related sources and have a negative impact on food production. The development of cost-effective solutions to minimize carbon waste and inhibit biogenic effluent gas emissions in sustainable biofuel production processes is still at an early stage of development. FLEXBY intends to go significantly boost this development by producing advanced biofuel through an innovative, cost-efficient process that will reach TRL5. At FLEXBY we will produce biofuel using biogenic waste from microalgae cultivated in domestic wastewater as well as the oily sludge from refineries.  This residual biomass will undergo a microwave pyrolysis treatment to produce three different fractions: bio-liquid, pyro-gas, and bio-char. The bio-liquid fraction will be converted to jet, diesel, and marine bio-fuels (heavy transport biofuels) through a versatile and innovative Hydrogen-free Hydrodeoxygenation. The gaseous fraction will be converted to bio-hydrogen through a steam-reforming water gas-shift process (WGS) and preferential CO oxidation (PrOx). Both liquid and gaseous biofuel will be tested and validated in fuel cells to produce electricity, along with an evaluation of their respective suitability for the transport sector. FLEXBY promotes a circular economy by recycling biomass residues and all sub-products obtained during the project.  The combined expertise of the industrially-driven consortium (formed by 1 LE, 4 SMEs, 2 universities, 1 non-profit association, and 2 RTOs) from 5 different countries will be able to achieve these objectiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Paediatric Clinical Research Infrastructure Network' under Horizon 2020.

assistant: **Concept**

Children’s health is a major societal challenge for Europe and the world, requiring development of paediatric medicines and treatments strategies based on evidence derived from clinical trials demonstrating efficacy and safety in infants and children, rather than on uncritical extrapolation from adult data (over 50 % of the medicines used for children had not been tested in this specific age group).Conducting clinical trials in children requires specific competences and infrastructure. ECRIN-ERIC (www.ecrin.org) is a generic infrastructure for multinational trial management, in any disease area. However it does not specifically address the paediatric needs in terms of trial management capacity. In its 2016 Roadmap, ESFRI suggested an upgrade of ECRIN to develop a common infrastructure for paediatric trial management through cooperation with the European Paediatric Clinical Trial Research Infrastructure (EPCTRI). The resulting PedCRIN project is also a unique opportunity to improve ECRIN business model and financial sustainability, attracting more industry-sponsored trials and more Member and Observer countries. PedCRIN builds on five work packages : project coordination (WP1); establishment of a strategy and upgrade of the governance and business plan, through a Sustainability Board jointly involving the scientific partners and the government representatives (WP2); development of tools specific for paediatric and neonatal trials (WP3) (methodology, outcome measures, adverse event reporting, bio-sample management, ethical and regulatory database, monitoring, quality and certification); operational support provided as transnational access to a few pilot trials to test the updated organisation and tools (WP4); communication targeting user’s communities (including industry)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Creation, evaluation and characterization of the ideal bioprobe for the cancer antigen Tn by improved selection of mutant lectins from phage display libraries'.

assistant: **Innovation**

Major changes in carbohydrate expression occur during the onset and progression of cancer. These alterations in glycosylation may result in both the loss of normal carbohydrate antigens (e.g. ABO blood group antigens) and/or high expression of carbohydrate structures that normally have low or restricted expression in healthy adults.The Tn antigen is expressed in most carcinomas, during embryogenesis, on pathogenic parasites, and on HIV, yet its expression is rare in normal adult tissue, creating a considerable interest in monitoring the expression of the Tn antigen for diagnostic purposes as well as for the development of Tn-based vaccines for cancer and HIV. The accurate detection of the Tn antigen is essential for both basic and applied research. However, monitoring the expression of this antigen is not trivial. Selective recognition of carbohydrate epitopes is challenging, especially for small epitopes such as the Tn antigen, and presently, there is no method nor approach providing an accurate and reliable information on the expression of this antigen.The goal of present proposal is to “evolve” the GafD lectin as a molecular probe to be used in the detection the Tn tumor biomarker and solve the problem of its recurrent inaccurate detection in cancer. Phage display technology will be used to modulate the properties of GafD throughout rounds of selection against different antigens, accumulating and refining its improvements in selectivity/affinity towards a finely tuned and specific Tn antigen binder. Subsequently, the identified receptor(s) will be expressed and fully characterized by an integrated multidisciplinary approach compressed of glycan microarrays, NMR; ITC; SPR and X-ray crystallography.The presented research will create a defined, precise and reliable tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomedical Applications of Radioactive ion Beams' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cancer remains one of the main causes of death worldwide. In 2018, >50% cancer patients in Europe underwent radiotherapy. While over 80% were treated using high-energy X-rays, the number of patients receiving accelerated protons or heavy ions (charged particle therapy: CPT) is rapidly growing, with nearly 200,000 patients treated up till now. Although CPT offers a better depth-dose distribution compared to common X-ray based techniques, range uncertainty and poor image guidance still limit its application. Improving accuracy is key to broadening the applicability of CPT. In BARB, we will open a new paradigm in the clinical use of CPT by using high-intensity radioactive ion beams (RIB), produced at GSI/FAIR-phase-0 in Darmstadt, for simultaneous treatment and visualization. This will reduce range uncertainty and extend the applicability of CPT to treatment of small lesions (e.g. metastasis and heart ventricles) with unprecedented precision. The Facility for Antiprotons and Ion Research (FAIR) is currently under construction at GSI.  RIB are one of the main tools for basic nuclear physics studies in the new facility. As part of the ongoing FAIR-phase-0, an intensity upgrade will increase the light ion currents in the existing SIS18 synchrotron. Within this project BARB, we will study four b+ emitters (10,11C, and 14,15O) and build an innovative hybrid detector for online positron emission tomography (PET) and g-ray imaging. This novel detector will acquire both prompt g-rays during the beam-on phase of the pulsed synchrotron beam delivery, and the delayed emission from b+ annihilation during the pulse intervals. The technique will be further validated in vivo by applying it to treatment of small tumors in a mouse model. BARB will exploit the potential of the Bragg peak in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stimuli Responsive Materials for the Rapid Detection and Treatment of Healthcare Associated Infections' in the context of a Horizon 2020 call.

assistant: **Objectives**

Healthcare Associated Infections (HAIs) are bacterial infections obtained as a result of clinical treatment e.g. following medical intervention. HAIs are a problem of tremendous proportion as more than 4 million EC citizens get infected annually. The ECDC estimates 147,000 HAI-related deaths in Europe each year, a large part stemming from wound infections. These alarming facts motivate the urgent need to develop novel medical devices, in particular wound dressings, which rapidly signal and prevent or eradicate invasive bacterial colonization following a stimulus. Current antimicrobial coatings rely on slow, passive diffusion of antimicrobials, hence the antimicrobial may not be sufficiently concentrated to eradicate the infection; such low concentration zones promote evolution of resistance. To tackle these challenges in healthcare in light of an increasingly aging population and unprecedented antibiotic resistance levels, there is an urgent need for dedicated research leaders in industry and academia. These scientists of the future still will need primary training in, e.g., chemistry or microbiology, but they will have to operate at the interface between disciplines. Future materials chemists will need to perform microbiology experiments and to appreciate the engineering required to translate a lab invention to a production prototype. They have to understand the societal, business and regulatory environment around new medical device development. The research focus of STIMULUS is on wound infections. The objectives are: 1) Diagnostic: To create materials that clearly and rapidly signal when infection is present; 2) Therapeutic: triggered release of antimicrobials to treat the infection; 3) Translational and theranostic: integration of responsive materials into prototype
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on '‘The Space and Sound of Silence: Embodied Political Communication and the Roman Senatorial Elite’'.

assistant: **Innovation**

Silence shouts, as the Romans recognised. Silence and absence are communicative strategies which are deployed and interpreted by actors and audiences according to the participatory expectations of a given field. This project is the first major study of silence and absence as communicative strategies in the Roman World. It focuses on members of the senatorial elite (including the women of senatorial families), who were highly skilful, creative, and influential actors in and interpreters of political culture, and it analyses the significance of their deployment of silence and absence as communicative strategies in the transition from the participatory system of the Republic to the autocracy of the Principate. The method encompasses the survey and analysis of textual material of various genres from the first century BCE – first century CE, with a particular focus on the relationship between the constructions of gender and of authority. This novel project will expand understanding of the performance dynamics of Roman politics and the frequency and significance of silence and absence as strategies within it. The larger issues of agency, participation, freedom, and resistance which the project addresses are pertinent now in light of the rise of the ‘new demagogues’ and the challenges facing contemporary democracies.


**Keywords:** Roman History, Classics, Political History, Gender
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Primate Network: specialized infrastructures and procedures for biological and biomedical research' in the context of a Sixth Framework call.

assistant: **Objectives**

Non-human primates play an important role in biological and biomedical research in Europe. This group of animals provides models, which are essential in the research area of genomics and biotechnology for health. Numerous aspects of biomedical research in this field depend on the availability of living animals or biological material with primate origin for the successful development of new strategies against human diseases.This includes infectious diseases (e.g. HIV, hepatitis, malaria), neurological diseases (e.g. Alzheimer's or Parkinson Disease), cancer research, the development of new therapeutics (vaccines, gene therapy), and transplantation research. The European primate centres exist because the high ethical demands of research on primates as well as the complexity of research on these species is best met through specialized, highly competent and adequately funded central facilities across Europe. This Integrated Infrastructure Initiative proposal will network the publicly funded European primate centres that combine research and breeding, covers the central aspects of primate research in biological and biomedical research and is aimed at advancing knowledge and competence in the areas of research, animal keeping and breeding. Due to the plethora of biological and biomedical research activities in the centres extensive knowledge and infrastructure resources already exist.Moreover, the centres have extensive experiences in primate housing and breeding. With an efficient network the existing knowledge and resources will be integrated and will enable an improvement of the basic and applied biological and biomedical research with primates and of housing and breeding conditions for primate. The proposals objectives focus on animal welfare, standardisation of procedure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation' (CANCERPREV).

assistant: **Concept**

Incidence and prevalence of many cancer types are significantly increasing worldwide, with substantial differences between the sexes. Environmental influences in concert with genetic and epigenetic factors are still poorly understood.Simultaneously, more sophisticated and expensive treatments cannot be afforded by society, increasing urgency of efforts in cancer prevention.CANCERPREV is an innovative interdisciplinary research and training program gathering seven academic beneficiaries and nine partner organizations : (one leading pharmaceutical company, one leading technology company, a health insurance, an internationally known nursing school, three foundations and two universities) in nine European countries. CANCERPREV aims to establish new strategies in cancer prevention, with a focus on two key determinants of cancer risk: sex hormone signaling and chronic inflammation, in breast and skin as benchmarks of early steps of cancer development in organs with reproductive and non-reproductive functions, respectively.Fifteen Early Stage Researchers (ESRs) will benefit from the complementary expertise of participating organizations and Principal Investigators in: basic cancer research, xenografts and genetic mouse models, bioinformatics and mathematical algorithms, epidemiology / human genetics, biomarkers, pharmacological approaches, behavioral / societal issues and outreach.This network provides ESRs with unique future career opportunities in both academic and private sectors, through research training for PhD thesis projects with secondments and short and long visits to other participating research institutions, and yearly courses / formal lectures on various aspects of cancer prevention, including global health and occupational / behavioral issues. CANCERPREV will ens