RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Business Models for User Centred Products' to be submitted under Seventh Framework.

assistant: **Abstract**

Recent research results by one of the partners have shown that human beings display unique behaviour (visual strategy), in the way they look at objects. Thus it has been (2006) possible to create spectacles with Progressive Addition lenses which were personalized to a subject’s visual strategy, finding that they dimensionally improved overall user experience, practically eliminating the spectacle-adaptation period and giving birth to new business models. The aim of our project is to research and define optimum Business Models by applying a systematic and generic analysis approach (Added Value Stack) to examine current and new business models by examining their margin buffers, sustainability, scalability and risks with the aid of available software modelling tools, and Software Simulators. The objectives of the project are:  * To identify and evaluate systematically potential business models with focus on personalisation of spectacles (lenses and frames).  * To render this business modelling approach applicable generically to other related visual systems markets and also applicable to other industries and products/services.  * To assess the risks and provide remedy strategies associated with the impact of potential spreads of the fundamental parameters of the model in a projected product-lifecycle. * To further develop and/or improve corresponding technologies enabling the practical validation and future implementation of the recommended business model. * To validate in practice at least one recommended business model through a demonstrator prototype. Deliverables of the project will be various researched business model(s) and the tested prototype of at least one model. That prototype demonstrator will consist of networked SMEs implementing and testing in practice the ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Negotiating post-imperial transitions: from remobilization to nation-state consolidation. A comparative study of local and regional transitions in post-Habsburg East and Central Europe' (NEPOSTRANS) under Horizon 2020.

assistant: **Objectives**

The project’s goal is to provide a new, overall narrative of how the Habsburg Empire was replaced by nation states at the end of WWI and reconsider in the light of its results categories and concepts like state and statehood, local, regional and national, transition and transformation. A novel combination of historical comparison and histoire croisée enables the in-depth analyses of a set of local transitions in diverse regions (agrarian, industrial, commercial, urban, rural, multi-and mono-ethnic, borderland and mainland, litoral) and the combination of these results with the existing literature on other localities.  The team addresses four main themes: state, elites, identities and discourses. The focus is always local, the question is how these societies faced the momentous changes and found their place within empire and nation-state(s). It will look at interactions, cultures and especially rupture and continuity of people, norms, practices, institutional cultures in order to discover patterns of transitions and the social factors influencing them. Besides a typology of transitions, it also aims at gaining a new perspective on empire and nation state from this crucial moment of collapse and state-building. The project is informed by New Imperial history, the idea of phantom boundaries, everyday ethnicity, integrated urban history. At the methodological level it builds on a symmetrical comparison of the selected cases and on an asymmetrical one with the existing literature, while the object of comparison is the transition that we conceptualize as an “intercrossing”. Through analysing this ‘transformation from below’ and connecting for the first time what has remained scattered both in historiography and in the social representations, the project aims to write a new hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Corona Accelerated R&D in Europe'.

assistant: **Concept**

The Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic has emerged as the largest global health threat to humanity in this century. According to the World Health Organisation Situation Report of March 28th 2020, 571,659 patients were diagnosed with Coronavirus Disease 2019 (COVID-19) and 26,493 deaths were reported globally. The wide spectrum of clinical symptoms, disease severity in high risk individuals, transmission efficiency and high mortality, raises an immediate need for vaccines or therapeutics. Given that the viral variant is new in the human population and emerged less than 4 months ago, there is no vaccine or approved therapies. The Corona Accelerated R&D in Europe (CARE) consortium is a coalition of 37 globally renowned academic institutions, pharmaceutical companies and non-profit research organizations who have committed to rapidly and efficiently address this emergent health threat, and the main objectives are:  the development of therapeutics (i) to provide an emergency response towards the current COVID-19 pandemic by drug repositioning and (ii) to address the current and/or future coronavirus outbreaks by broad-spectrum small-molecule drug discovery and/or virus-neutralizing antibody discovery. To achieve this, a collection of repurposed drugs, focused libraries and small molecule libraries will be screened against SARS-CoV-2, other emerging SARS-CoV-2 clades and related coronavirus genera in phenotypic or target-based assays. A focused medicinal chemistry campaign will identify small-molecule hits, and Absorption, Distribution, Metabolism and Excretion (ADME), pharmacokinetic/pharmacodynamic (PK/PD), potency and safety of these therapeutic candidates will be assessed in vitro and in animal models. Virus-neutralizing monoclonal antib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microbial Synthetic in vivo Cell Therapy Systems' (MiStiC) under Horizon Europe.

assistant: **Objectives**

Bacteria are among the most brilliant chemists on Earth. They are capable of producing a wealth of structurally diverse natural products with a wide range of applications in medicine, such as the treatment of infections and cancer. The synthetic production of microbial natural products and their transformation into pharmaceutical drugs is often a challenging, costly and time-consuming process due to the structural complexity of these molecules and the difficulties associated with drug solubility and formulation.An emerging new strategy in disease treatment aims to exploit beneficial intestinal microbes for ‘local’ drug production and delivery. Such commensal bacteria are safe, can be administered easily, and can be engineered to detect diseases and release drugs in adequate local concentrations. However, the current therapeutic platform or ‘chassis’ strains cannot stably colonize the human gut and have so far only been engineered to produce therapeutic proteins, such as hormones or cytokines. As a result, no commensal chassis strains are available to treat chronic intestinal diseases or to produce clinically important natural product therapeutics.In MiStiC, I propose to revolutionize microbial therapy systems by developing the beneficial, stable and prominent gut colonizer Clostridium leptum as an innovative and superior chassis for long-term health monitoring and chronic disease treatment. I will combine my expertise in molecular microbiology, enzyme engineering and natural product biosynthesis to equip the chassis with a nanobody-based biosensor and biocontainment modules, and optimize it for the expression of natural product biosynthetic pathways. As a proof-of-concept, we will implement these tools and chassis strains for the detection and treatment of colorectal ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'TARGETING TUMOUR-VASCULAR/MATRIX INTERACTIONS'.

assistant: **Concept**

This project intends to explore and validate new targets and pathways for innovative treatment of solid tumors directed towards tumor vascular matrix interactions, define validated targets towards tumour neovessel formation and create effective and tumour-selective strategies that complement or subsitute established therapies. The apparent lack of success in translating angiogenesis research into the clinic is in our view based on the fact that the research field is fragmented, and no standardized tools and models have been identified that reliably reflect the complexity of tumour angiogenesis mechanisms in humans. This integrated project will identify and validate new therapeutic targets directed towards tumor vascular-matrix interactions, develop new therapeutic strategies and implement such strategies in pre- and clinical trials. The project will represent a virtual research institute ine Europe and consists of 14 higly competent research centers within the field of angiogenesis research. To define and validate new targets related to the tumour vascular transcriptome and proteome, the consortium will etablish high throughput functional screening technologies for the identification of novel secreted factors that regulate endothelial cell growth and survival. This includes the use of robotics platforms that will be used to identify cDNAs with specific cellular functions. In this application, basic science, translational research and clinical activities are strongly intergrated, in order to validate defined targets and new therapeutic principles for clinical implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimised Electric Network Architectures and Systems for More-Electric Aircraft' (ORCHESTRA).

assistant: **Concept**

ORCHESTRA combines: · The leading University in Europe (UNOTT) on Aircraft electrification, · Europe’s leading Regional Aircraft Company (LDO VEL), · The world largest provider of aircraft Systems (SAF & SEP), · Leading experts on Thermal Management (CIRA&FhG) and Electrical Energy Storage Technologies (AIT), · Innovative businesses specialising in technologies for Aircraft Electrification (SKLE, BSIM &AER) · Leading experts with decades of experience in aircraft certification (VR-ASP) to deliver the “Technological Building Blocks” (TBB) that will form the foundation for the development of Much More Electric Aircraft (M2EA). The key quantitative objectives achieved by ORCHESTRA will include overall EPS weight reduction by 25% and improvement in EPS efficiency by 10% compared to the current state-of-the-art. The ORCHESTRA consortium will investigate all the relevant technical aspects including electrical architectures, machines, power management and control, harness solutions, thermal management, electric energy storage, experimental and virtual testing, as well as systems integration, to develop and deliver a holistic framework of innovative modular scalable “building blocks” that incorporate emerging technologies and breakthrough design ideas. Each partner within the Consortium has been carefully selected due to their world leading expertise in the technology areas indicated Figure 3. The involvement of VR-ASP, with decades of experience on aircraft certification, is noteworthy to ensure that TBBs delivered through ORCHESTRA will be designed with a clear path to certification from the outset. This will be complemented through the involvement of EASA on the Industrial Advisory Board.


**Keywords:** Aerospace Electrification, Electrical Networks, Electrical Architecture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A future for radioecology in Europe' (FUTURAE) under Sixth Framework.

assistant: **Objectives**

European and national funding for radioecology was substantial after the Chernobyl accident, but has since declined. In the last decade, the number of radioecologists has been steadily reducing with significant gaps occurring in many countries in the expertise needed to cover the many different facets of radioecology. Recent reports have identified the need to ensure that the discipline is maintained across Europe and beyond. Some Member States may not be able to adequately respond to future large scale accidents or to address knowledge gaps in respect to new regulatory requirements. Issues within radiation protection are cross-boundary and we may need to bring together the remaining European radioecological expertise to make best use of experience and resources, and ensure an appropriate future for radioecology in Europe. The primary objective of this CA is to evaluate the feasibility of network(s) to maintain and enhance competence and to enhance sustainable collaboration in the field of assessment and management of the impact of radionuclides on man and the environment. To reach this objective, the present CA proposes a number of tasks that includes: (i) evaluation of the current situation of research in radioecology in Europe and beyond (scientific programmes, human resources, infrastructures, funding), (ii) focused interaction with end-users representing national bodies, competent authorities, industry and scientists to assess the present and future needs in radioecology, (iii) evaluation of the capacity to support future needs and identification and prioritisation of new challenges considering potential avenues for better collaboration in broader areas of environmental sciences. From these tasks, the output of the project will be an evaluation of the potential for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How to minimize the ecological footprint for functional electronics?' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

A growing desire for continuous data collection, real time information and connectivity has resulted in increased demand for electronic functionalities that are fully integrated in everyday objects. Consumer electronics, healthcare, wearable electronics, IoT and smart packaging are examples of market segments that follow this trend. Printed circuit boards (PCBs) are the state of the art to create electronic functions; however, this technology creates an ever increasing strain on the environment because recycling and/or dismantling of the PCB can hardly be done. A radical sustainability improvement requires disruptive electronics manufacturing processes, technologies and materials.  Printed electronics are more environmentally friendly than the traditional PCB, due to their additive character (printing instead of etching), the absence of chemical etching materials, low energy demanding process conditions and possibility for recovery or re-use of substrates and (metallic) inks. Thereto, in ECOTRON, flexible, organic & printed electronics are advanced through a multidisciplinary approach involving biobased materials, innovative (print) processes, and device and module dismantling technologies. Furthermore, recycling technologies and standards will be developed that are eventually integrated in a process design for a printed electronics recycling plant. Simultaneously, the lifetime of printed electronics is improved for larger implementation of printed electronics into everyday products. ECOTRON will create use-case demonstrators in existing state-of-the-art electronics products in consumer electronics, smart packaging, healthcare and wearable electronics market segments to demonstrate the potential environmental enhancements.


**Keywords:** flexible, organic & printed ele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated study of the guadiana estuary and adjacent shelf' (1998-2002).

assistant: **Concept**

The proposal aims to study in an integrated manner a complete estuarine system which also comprises the adjacent shelf, the Guadiana River estuary (SW border between Spain and Portugal), by means of high- resolution seismics and side scan sonar records.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Defining the origin of Barrett’s oesophagus by exploring a submucosal gland stem cell model' (ORIBAR).

assistant: **Innovation**

Esophageal adenocarcinoma is the most rapidly increasing form of cancer in the Western world characterized by short survival times. Its precursor lesion is Barrett’s oesophagus, which is present long before oesophageal adenocarcinoma arises. This offers an opportunity for prevention. However, the cell of origin of Barrett’s oesophagus is unknown. This represents a huge knowledge gap and impairs the development of preventative and curative therapies.My research has shown homeobox transcription factor HOXA13 is expressed in both Barrett’s oesophagus and in a fraction of oesophageal submucosal gland cells, but not in differentiated epithelial cells of the oesophagus or stomach. The submucosal glands have been proven to have positional and mutational kinship with Barrett's oesophagus. Therefore, they likely contain its cell of origin. Currently, the only models with oesophageal submucosal gland cells are large laboratory animals. These don't contain human cells, are impractical, costly and unethical in their use. Therefore, I propose to establish and validate the first human, 2D, organoid based, model of these glands.I propose to test if submucosal glands contain the (HOXA13+) tissue specific stem cell of Barrett's oesophagus by employing single cell culture and single cell visualisation techniques. If proven, the resulting identification of the cell of origin of Barrett’s oesophagus would open a clear path to understanding mucosal plasticity and early stage oesophageal carcinogenesis. I propose to elucidate the characteristics of this cell of origin and identify which signaling pathways mediate the emergence of Barrett’s oesophagus. The proposed host group of Prof. Krishnadath is well-positioned for executing this project due to their access to relevant tissues and experie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Disruptive and high accuracy test for early colorectal cancer detection in blood' to be submitted under Horizon Europe.

assistant: **Abstract**

AMADIX is a leading molecular diagnostics company, led by Rocío Arroyo, focused on liquid biopsy, developing innovative diagnostic tests for early cancer detection in blood. Colorectal cancer (CRC) is the 2nd leading cause of cancer-related deaths worldwide. Most of these cancers and deaths could have been prevented by increasing the use of recommended screening tests that detect premalignant lesions, called advanced adenomas. Colonoscopy is the gold standard screening method, although it is an invasive and expensive procedure.AMADIX has previously developed an innovative blood-based test for CRC diagnosis (ColoFast), based on an initial combination of cutting-edge biomarkers (micro-RNAs) and validated in +1,000 samples. Indicated to screen healthy population from 50 to 85 years old,has shown superior performance in early cancer detection than any of the tests commercialized, better compliance and cost-effectiveness and is being validated in a European prospective study with 3,100 patients (recruitment concluded) granted by SME Phase 2 with €2.8M. AMADIX has identified new promising biomarkers to be incorporated to the initial signature, to improve the diagnostic performance. AMADIX has taken advantage of the potential of Artificial Intelligence and Big Data to identify CRC risk factors from the patients’ clinical records and develop diagnostic prediction models. Our goal is to validate this new signature, PreveCol, more accurate than the initial combination, based on different types of biomarkers, followed by its commercialization as LDT and as IVD kit. In addition, a risk factors-based algorithm will be incorporated, enabling to predict and identify individuals with a high risk of developing CRC or premalignant polyps, even if they are younger than 50 years old, impro