RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Multiple Designer Organelles for Expanded Eukaryotic life' (MultiOrganelleDesign).

assistant: **Concept**

The emergence of organelles dedicated to specific cellular functions drove the evolution of more complex eukaryotic organisms. We recently created membraneless organelles inside eukaryotic cells dedicated to orthogonal translation, which opened a new path to residue-specific protein engineering using genetic code expansion. We now want to design novel organelles into eukaryotes that will internally enact the entire central dogma of molecular biology. This will supplement the complex eukaryotic cell with an additional simple and easily tailored orthogonal machinery that can also facilitate transcription and replication. This will enable us to create eukaryotes that have more than four additional expanded genetic codes, and we will explore the functional space occupied by these novel living systems. The organelles will be enhanced to process specific signals to e.g. modify RNA or degrade specific proteins. Besides these curiosity-driven goals, specific applications will allow us to road test our technology. We will directly use these approaches to advance protein engineering in eukaryotes to create proteins and artificial peptide polymers having multiple, noncanonical functionalities suitable for diverse biotechnological applications and new bioinspired materials. We will also develop organelle design into a truly universal and powerful labeling method fully compatible with eukaryotic host cell physiology that has single-residue precision and goes way beyond the state-of-the-art of any fluorescent labeling technology. The approaches will be general and truly flexible in how translation can be tailored in terms of protein, RNA and codon choice, including sense codons and type of new functionalities. Progress made in recent decades has shown that protein design and engineer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Gene Therapy for Inherited Skin Adhesion Disorders'.

assistant: **Innovation**

Epidermolysis bullosa (EB) is a family of severe skin adhesion defects characterized by disfiguring blistering, infections, visual impairment, and a high risk of cancer. We showed through pre-clinical and clinical investigation that transplantation of genetically corrected epithelia leads to long-term functional correction of EB. The current vectors, however, integrate in an uncontrolled fashion in the human genome, a cause of genotoxicity and potentially severe adverse events. The objective of this project is the development and pre-clinical evaluation of new gene targeting and gene correction technology, aimed at integrating therapeutic transgenes at specific loci or at correcting genetic defects by homologous recombination. Epidermal stem cells (EpSCs) and EB are ideal targets for the design and development of such technology, which is expected to have an impact on gene therapy of many other genetic diseases. We will design and test novel viral vectors for homologous recombination based on site-specific integrases and Zn-finger nucleases, and non-viral vectors for integrating large genes and complex regulatory sequences based on vertebrate transposons. All vectors will be tested in repopulating human EpSCs in vitro and in vivo, in a pre-clinical model of xenotransplantation of human skin on immunodeficient mice. A parallel, basic research program will aim at applying existing and novel genomic approaches to the definition of transcription factors, regulatory regions and gene expression programs involved in self renewal, commitment and differentiation of EpSCs. The anticipated output of the project is the development of next-generation technology for gene transfer, and the establishment of a knowledge base for a better utilization of EpSCs in gene therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'AI powereD characterization and modelling for GREEn  STeel technology'.

assistant: **Concept**

The fourth industrial revolution and market demands for advanced steels are driving the research towards transformation of the manufacturing processes and to ever-more sustainable steel compositions. The conventional ‘trial and error’ approach traditionally used to develop metallurgical processes still prevails in the industrial steel plants. However, it is a time-consuming, labour-intensive process entailing high material waste and associated carbon emissions. Also, it can ultimately lead down to a repetitive path that consists of creating a process design, putting it into production, and detecting possible process design flaws too late, resulting in high component rejection rates. Ascertaining the inadvertent flaws in the manufacturing approach before its implementation on industrial lines could be the key to major cost savings. With the introduction of AI- and simulation-driven design, back-and-forth interaction between part and process designs can be significantly diminished.The main objective of AID4GREENEST is to develop six new AI - based rapid characterization methods and modelling tools. AID4GREENEST tools’ scope will cover the steel design (chemistry and microstructure), process design (processing parameters), product design (processing and heat treatments) and product performance (creep) stages. Proposed tools will be complemented with a roadmap designed to enable model-based innovation processes, from materials design to product development, while considering the industry needs: enhanced material quality, reduction of carbon emission and waste generation, and reduced supply risk of critical raw materials. In order to facilitate the knowledge transfer of the characterization and modelling data generated in this project and across the wider European characteri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multiple cellular screens using microfluidic droplets' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Although some biotechnologies have made huge strides e.g. in automation, data generation, or biochemical methods, cellhandling still uses antiquated methods that limit the scale at which assays can be performed. Our ERC-funded microfluidicswork has lead to cutting-edge microdroplet manipulation tools for cell handling: While working with 3D cell cultures, wehave recently shown that we can obtain great increases in both throughput and detail, while reducing the sample use andthe machine footprint. In addition to these quantitative leaps, the microfluidic format also allows qualitatively new biologicalconstructs to be explored by making significant steps towards the organ-on-a-chip framework. The current project thereforeaims to show how the technologies developed in our lab can function together in an integrated cell screening platform. Thiswill require demonstrating a convincing proof of concept of the hardware, software, and workflow, in addition todemonstrating the added value to different industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Water Harvesting for Rainfed Africa: investing in dryland agriculture for growth and resilience' (WAHARA), addressing dissemination and exploitation.

assistant: **Impact**

WAHARA will take a transdisciplinary approach to develop innovative, locally adapted water harvesting solutions with wider relevance for rainfed Africa. Water harvesting technologies play a key role in bringing about an urgently needed increase in agricultural productivity, and to improve food and water security in rural areas. Water harvesting technologies enhance water buffering capacity, contributing to the resilience of African drylands to climate variability and climate change, as well as to socio-economic changes such as population growth and urbanisation. To ensure the continental relevance of project results, research will concentrate on four geographically dispersed study sites in Tunisia, Burkina Faso, Ethiopia and Zambia, covering diverse socio-economic conditions and a range from arid to sub-humid climates. The project emphasizes: i) participatory technology design, i.e. selecting and adapting technologies that have synergies with existing farming systems and that are preferred by local stakeholders, yet tap from a global repertoire of innovative options; ii) sustainable impact, i.e. technologies that combine multiple uses of water, green and blue water management, and integrated water and nutrient management. Using models, water harvesting systems will be designed for maximum impact without compromising downstream water-users, contributing to sustainable regional development; iii) integration and adaptability, i.e. paying attention to the generic lessons to be learned from local experiences, and developing guidelines on how technologies can be adapted to different conditions; and iv) learning and action, i.e. a strategy will be developed to enable learning and action from successes achieved locally: a. within a region, to upscale from water harvesting techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High productivity and low cost for the encapsulation of thin film solar cells,(HIPROLOCO)' (HIPROLOCO) under Fifth Framework.

assistant: **Objectives**

Objectives and problems to be solved :The state of the art encapsulation technology for thin film solar cells of double glass encapsulation with encapsulant EVA should be changed significantly to decrease the efforts in material, energy time, handling and cost. New flexible encapsulating materials, One component encapsulants" which include all encapsulating functions such as -sealing / embedding-"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Salvador da Bahia: American, European, and African forging of a colonial capital city' (BAHIA16-19) targeting Seventh Framework.

assistant: **Abstract**

The project Bahia16-19 aims at creating a top-level research and advanced training network on the colonial history of the Atlantic. The coordinator, Universidade Nova de Lisboa (Portugal), promotes this network together with the Federal University of Bahia (Brazil) and with Ecole des Hautes Etudes en Sciences Sociales (France). The aim of this proposal of mobility scheme is to give birth to a trans-Atlantic web of faculties and advanced students, specialized in the long-term history of colonial Atlantic. The partners have chosen to focus on Salvador de Bahia, and to study its role and functions as a capital city in an imperial context. In Salvador de Bahia European settlement, native cultures, and African forced migration created a multi-cultural society. Due to this fact, this city was undoubtedly an exceptional place. Covering the period from the 16th century to the post-independence era, the ensemble of researches due to be carried out within the project will provide an archival based and reflexive addition of up-to-date knowledge. The promoters of the project share the assumption that Salvador da Bahia may be the shortest way to link European scholars with African history and historiography.  The recent Brazil’s massive investment in research and training on African history and society had become a major resource to reformulate also European approaches to Africa. Another major output of the project is the joint Master’s proposal on Trans-Atlantic colonial history. Such a course will be a dramatic move forward in the relations between the European, the Brazilian and the African scholarships. The applicants think of offering further partners from African universities to join our Master’s syllabus and, at the end of this program, to apply to a Erasmus Mundus training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The use of stroke registers to assess the quality of stroke management across europe (EROS)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

EROS is a 4-year prospective study across Europe that will develop methods and collect data in European populations to estimate the impact of stroke and assess the quality of stroke care. The main objective is to understand the factors underlying variations in the quality of care and outcome after stroke. The strength of the study is the detailed clinical and healthcare information that will be collected from unbiased population registers using standardised, novel, data collection methods. The data will be able to answer unresolved issues with regard to the influence of sociodemographic, case mix and stroke healthcare quality factors on the variations in health of stroke patients around Europe. Refinement of methodologies to estimate quality, health related quality of life and health economic impact of this disease of public health importance would aid researchers and health care planners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Highly Automated Air Traffic Controller Workstations with Artificial Intelligence Integration' (HAAWAII).

assistant: **Innovation**

Advanced automation support developed in Wave 1 of SESAR IR includes using of automatic speech recognition (ASR) to reduce the amount of manual data inputs by air-traffic controllers. Evaluation of controllers’ feedback has been subdued due to the limited recognition performance of the commercial of the shell ASR engines that were used, even in laboratory conditions. The reasons for the unsatisfactory conclusions include e.g. inability to distinguish controllers’ accents, deviations from standard phraseology and limited real-time recognition performance. Past exploratory research funded project MALORCA, however, has shown (on restricted use-cases) that satisfactory performance can be reached with novel data-driven machine learning approaches. Based on the results of MALORCA HAAWAII project aims to research and develop a reliable, error resilient and adaptable solution to automatically transcribe voice commands issued by both air-traffic controllers and pilots. The project will build on very large collection of data, organized with a minimum expert effort to develop a new set of models for complex environments of Icelandic en-route and London TMA. HAAWAII aims to perform proof-of-concept trials in challenging environments, i.e. to be directly connected with real-life data from ops room. As pilot read-back error detection is the main application, HAAWAII aims to significantly enhance the validity of the speech recognition models. The proposed work goes far beyond the work planned for the Wave 2 IR programme and will improve both safety and reduce controllers’ workload. The digitization of controller and pilot voice utterances can be used for a wide variety of safety and performance related benefits including, but not limiting to pre-fill entries into electronic flight str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Study of galactic interaction and merging using n-body simulation techniques'.

assistant: **Objectives**

I plan to study the interaction and merging of galaxies via N-body simulations. The use of high performance computer facilities will allow me to investigate merging in compact groups of galaxies using direct summation N-body codes. Thus the simulation will be self-consistent and will not be affected by the geometry of the system.  I will use the final steps of the evolution of these simulations to stu the structure of merger remnants. I plan to look at the shapes of the remnants, the distribution of matter and their kinematics. I would like to make detailed comparisons of my results with observational data, and to check whether elliptical galaxies can be merger remnants of compact groups.  I plan also to study the orbital structure of the remnant of a merger between two individual galaxies. We will make statistical study of the orbits of stars and see how these depend on the parameters of the encounter orbit and on the type of the two merging galaxies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Increasing safety by enhancing crew situation awareness' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The density of air traffic increases steadily with local congestion becoming more and more of a problem. These increasing traffic demands call for innovative system solutions on-board aircraft to improve the current safety and reliability standards. ISAWARE II is a major contribution to solve the issue of improving both safety and efficiency of flight operations. The project aims at a better communication between the pilot and its avionics system, by applying an interactive concept and providing the crew with a self-intuitive presentation of the whole external situation. ISAWARE II innovative technologies work towards an improved crew situation awareness leading to an increased global safety. The introduction on the market shall lead to a reduction of at least 5% per year of the Approach and Landing related Controlled Flight Into Terrain (CFIT) accident occurrence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Perception of Time during Action Preparation' under Seventh Framework.

assistant: **Concept**

Expert baseball players commonly report that they feel the ball ‘slowing down’ when about to swing their bat. Their comments raise an interesting question of how humans perceive time prior to action, in other words, how motor preparatory activity effects on visual processing to change the subjective flow of time.Every daily event is associated with time, and we intuitively feel that we live on a constant and continuous time line. However, studies have revealed that physical temporal events and the perception of these events are not always matched. This counterintuitive nature of temporal perception has fascinated philosophers and scientists for centuries. Since humans are moving animals, perception of time must also be studied in an active situation. However, most studies relating temporal perception have, thus far, focused on static sensory processing and few studies have addressed how action can modulate an actor’s perception of time.The aim of this proposal is to understand the modulation of human temporal perception in an active context; focusing on the period when the brain is preparing for action. A series of behavioural and electrophysiological studies will be conducted to reveal the neuronal mechanism involved in this process. State-of-art machine learning algorithms will be used to analyze brain activity, and also a recently developed brain stimulation technique will be used to modulate brain activity, in order to elucidate the causal relationship between brain activity and temporal perception.The proposed research is expected to advance research in neurocognition of action, a distinctively European research field, by incorporating state-of-art research techniques. It will also facilitate interdisciplinary interaction between related fields (neuroscience, psych