RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Immunoregulation during early antimicrobial responses' in the context of a Sixth Framework call.

assistant: **Objectives**

This proposal is aimed at promoting the collaboration of two European research teams (the team of Dr. B. Gicquel at the Institut Pasteur of Paris, as the Host Institution and Prof. P. Ricciardi-Castagnoli from the University of Milano-Bicocca) in the emerging field of immunogenomics applied to research in the area of immunity to infections with a particular focus on tuberculosis.The availability of a M.Curie Chair will unable the promotion and the diffusion of a new approach in the studies of host-parasite interaction; this approach will be based on functional genomic technologies to reveal, at a global scale, the induced differential expression of genes occurring in the host and in the pathogen during their interaction.The two leading expertises will cross-fertilize this interdisciplinary approach for the benefit of the scientific community and the training of many early stage researchers. In addition a new PhD programme will be launched in order to expose European students to new cutting edge I.D.E.A.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MENTEE - Mastery learning in Europe through Technology Enhanced Education' (MENTEE).

assistant: **Innovation**

The proper education of our pupils is essential for the future of Europe, however, it is demonstrated that the current educational models are not meeting the expectations. How can we optimise and update these old-fashioned approaches to guarantee the best apprenticeship?We, InfoMentor, want to develop MENTEE, a unique web-based Mastery Learning platform fully tailored to the different National Curriculums (programmes of study) of EU countries. Thanks to its automated features, it will suppose a shift in the teaching profession that will reignite the passion of teachers and their students.We have detected two main problems in the EU educational systems: 1) Inefficient procedures, with paperwork drowning up to 50% of the teachers’ work time in bureaucracy; and 2) Summative assessment, an outdated assessment approach that causes between 17%-20% of young people falling below the minimum standard in key subjects ranges.In order to break this cycle, we have created MENTEE, an educational platform that enables: 1) Efficiency, by reducing by 50% the efforts of teachers allocated to administrative and planning tasks; and 2) Enhanced assessment, by promoting the educational mastery through formative assessment (where students’ progress is continuously monitored through automated, education-tailored tools) and mastering learning (which requires students to fully master an assignment before moving on to the next one).Our business opportunity is promising; the Education market is a €4,700 billion global industry (estimated growth of 10% from 2015 to 2019) and it is only 2% digitised, with a huge gap between technology availability and actual implementation in schools (textbooks still are the main resource for pupils learning how to read), supposing a huge potential for digital solut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-messenger AI-enhanced earthquake early warning' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Earthquakes caused nearly one million fatalities in the last two decades and billions of euros of economic loss. In our current state of knowledge, these hazardous events remain unpredictable. Early Warning Systems (EWS) exist in some countries at risk, but they only send alerts once the earthquake has started, leveraging information recorded close to the epicenter before the most destructive seismic waves reach more distant populated areas. These systems provide – in the best-case scenarios – only a few seconds of warning before the strongest shakings. Moreover, for fundamental reasons, they systematically underestimate the magnitude of large events, which results in dramatic underestimation of potential subsequent tsunamis, which typically cause most of the fatalities and damage. Therefore, making EWS faster and more accurate is crucial to mitigate the hazard associated with these catastrophic events. In the framework of the ERC StG project EARLI, we developed prototype Artificial Intelligence (AI) algorithms providing faster and more accurate theoretical estimates of the location and magnitude of large earthquakes than state-of-the-art EWS. We propose to implement these AI algorithms in the operational EWS of Peru, with the objective of transforming the theoretical developments of the ERC StG EARLI (Licciardi et al., Nature, 2022; Lara et al., JGR, 2023) into concrete operational improvements in EWS performance. The algorithms we developed use short records of traditional seismic waves and light-speed gravity signals. We will complement these two algorithms by a third AI-based one using GNSS, allowing the implemented EWS to leverage complementary real-time data, and making it the first operational multi-messenger AI-based EWS. The system will rapidly benefit millions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A REVOLUTIONARY SAFE, QUIET, LONG RANGE, PERSONAL VERTICAL TAKEOFF AND LANDING (VTOL) DEVICE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

World urban population is expected to grow by 2.5B in 2050, causing severe delays to commuter, freight and first responder mobility. This costs Europe €100B yearly and is anticipated to cause a productivity loss of €238.7 billion annually for UK, France, Germany and the USA in 2030. Various proactive actions have been proposed in recent years, with exciting developments emerging in air urban mobility, focused on personal vertical lift off, VTOL, aircraft. Many solutions developed so far are mostly electric powered limiting flight endurance to a maximum of 30 minutes due to immature battery technology, unreliable safety, bulky design (rotor configuration >4m) and excessive noise. As VB Hi-Tech Ventures, our start-up company specialising in the design of personal flying devices, we developed Audax Aero, a VTOL aircraft designed to improve flight distance to a range of 300km/2 hours without refuelling, while improving pilot safety thanks to a hybrid propulsion system that also reduce noise levels. Our target users are first responders, cargo delivery companies, commuters and recreational industry who need quick transportation and improved mobility to inaccessible areas. We are targeting the UAVs for first responder market projected to reach €106B in 2019, UAV market which is expected to grow by €1.69B from 2016 to 2023 and VTOL market which is expected to reach €4.3B in 2026. We have invested €150,000 for the development of Audax Aero and we will validate the functionality and specifications by conducting computer simulations and testing a prototype to be built in Phase 1 as well as search for development and component supply partners. In addition to developing an Intellectual Property strategy and dissemination plan, we will also outline the activities and timelines for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'South Moravian Programme for Distinguished Researchers 3'.

assistant: **Innovation**

SoMoPro 3 is an innovated regional fellowship programme building on its two predecessors, SoMoPro (2009–2013) and SoMoPro II (2012–2017). The program was established in 2009 after a successful application to the COFUND scheme. Since then 4 calls for proposals have been open: in 2009, 2010 and 2012, 2013 with 53 fellowships funded. The objective of this application is to launch 2 more calls and support 20 more fellows.SoMoPro 3 incorporates main features of MSCA and offers incoming researchers attractive conditions and environment (e.g. state-of-the-art equipment in newly build infrastructures). Its aim is to foster international mobility, attract high-quality researchers, provide them training and career development and boost the growing innovation activities in the South Moravian Region.The programme combines extensive experience enriched with new qualitative features – research topics in line with domains defined in regional S3 (while emphasising interdisciplinary approaches), closer interaction with key industrial players based in the region (offering researchers an opportunity to gain intersectoral experience) and modified administrative procedures (to allow greater flexibility and decrease the administrative burden).The reason to apply for another COFUND is not only the financial contribution which will enable to fund the fellows (as there is no such funding available on the Czech national level). It is also the fact that it increases international recognition of the programme and provides a well known “mark of quality”. It is for the benefit of the researchers, who become Marie Skłodowska-Curie fellows, of the regional host institutions, which profit from hosting high-quality researchers as well as of the region itself as it profits from interaction between high-q
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ZeroPM: Zero pollution of Persistent, Mobile substances' (ZeroPM), addressing dissemination and exploitation.

assistant: **Impact**

ZeroPM will interlink and synergize prevention, prioritization and removal strategies to protect the environment and human health from persistent, mobile (PM) substances. To do this, ZeroPM will establish an evidence-based multilevel framework to guide policy, technological and market incentives to minimize use, emissions and pollution of entire groups of PM substances.To prevent pollution, ZeroPM will activate the momentum of the EU's Chemicals Strategy for Sustainability and support its implementation through the development of scientific, policy and market tools supporting essential use and mitigation of prioritized PM substances, resulting in substitution to safe and sustainable alternatives. ZeroPM will prioritize PM substances and substance groups through the development and application of robust screening and prioritization tools aimed at identifying all PM substances on the global chemical inventory. These tools will take into consideration production, use, presence in the circular economy, hazard and risk established by advancing in silico and in vitro new approach methodologies (NAM) using non-animal approaches. ZeroPM will develop next generation remediation techniques to remove prioritized PM substances from water resources, drinking water and sludge-derived products sustainably. ZeroPM unites leading researchers, regulators and green chemistry innovation experts that have been instrumental in advancing the science and awareness of PM substances, to form an exemplary multidisciplinary team. ZeroPM will deliver policy improvements, an increase in business opportunities and competitiveness, an improved livelihood for EU citizens and beyond state of the art methods, to prevent regrettable substitution and regrettable remediation of PM substance groups. ZeroPM w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'GENomic evolution In Ecological Speciation'.

assistant: **Innovation**

Speciation is the major process creating diversity of life on Earth. The proposed study will focus on the genomics of ecological speciation. Little is known about constraints on ecological speciation and the effects that the shift in the spatial arrangement of habitats has on the differentiation process. Goal of this project is to discover how past environmental changes effected differentiation in the genome of Murella muralis, a land snail that has an impressive shell shape diversity displayed on a small geographical scale. Using a genotyping-by-sequencing approach based on a Illumina next-generation sequencing, the project will survey genome-wide patterns of divergence across the genome of M. muralis and allow conducting population genomics analyses on the resulting single nucleotide polymorphisms (SNPs). Three specific objectives will be addressed. (1) The demographic history will be tested to infer the “history of gene flow” and disentangle different models of divergence. (2) The fine palaeogeographical and past climatic knowledge of the study area will allow defining the effects of environmental changes on genomic variation in the course of time. This is a general key point in the study of speciation (geography and time-course of speciation). (3) Do shell traits map in regions of strong divergence? Two methods (i. estimate peculiar patterns of introgression in admixed populations; ii. crossing experiments, QTL mapping approach) will be used to test if highly differentiated regions are in regions of reduced introgression and separate differentiated regions under selection, linked to shell traits, from random population divergence.The key novel aspect of the project is that I will have the unique opportunity to search in detail genomic constrains on differentiation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of neuronal intracellular traffic in Alzheimer´s disease' (TRAFFICINAD) targeting Seventh Framework.

assistant: **Abstract**

In neurons of Alzheimer’s disease (AD) there is an  aberrant accumulation of beta-amyloid (Aβ) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in Aβ accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in Aβ accumulation that leads to AD. We will determine how the intracellular itinerary of the amyloid precursor protein in neurons influences the generation of Aβ. We will determine the intracellular trafficking of lysosomal hydrolases in neurons and their contribution to the lysosomal clearance of Aβ. Furthermore, we will investigate the mechanism whereby regulators of intracellular trafficking identified as risk-factors for AD contribute to Aβ accumulation. Finally, because aging is the most important risk factor for AD, we will determine if alterations in intracellular trafficking occur in aging, identifying a new mechanism of vulnerability to neurodegeneration in AD. Thus, we will demonstrate how intracellular trafficking is implicated in AD and unravel an important disease mechanism.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Investigating the impact of meditation training on mental health and wellbeing in the ageing population'.

assistant: **Concept**

As the number of older people in Europe grows, increasing healthy life years is a priority. Cognitive decline, dementia (e.g. Alzheimer’s disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that lifestyle factors and meditation practice have the potential to downregulate these adverse factors and positively impact mental and neurological conditions including AD. Our main objectives are i) to improve early AD detection and understanding of physiopathological mechanisms; and to investigate ii) the impact of internal/external (e.g. genetic and lifestyle) determinants and iii) the effect and mechanisms of action of meditation training, on mental health and wellbeing in older people. This will be achieved by using pre-existing databases from European partners and conducting two randomized controlled trials (Studies 1 and 2B) and one observational study (2A). STUDY 1 will assess the short-term effects of an 8-week meditation intervention (versus cognitive training) in patients with subjective cognitive decline at risk for AD on behavioural measures including anxiety and wellbeing. STUDY 2A will assess senior expert meditators to identify neural signatures of different meditation practices on attention and emotion regulation tasks. STUDY 2B will assess long-term effects of an 18-month meditation intervention (versus an active control) on behavioural and biological markers of mental health and wellbeing in cognitively intact elderly. The cognitive and affective regulatory mechanisms underlying these effects will be investigated using the neural signatures identified in the expert meditators. High public health relevance is likely: t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Gene Therapy for treatment of rare inherited Arrhythmogenic Cardiomyopathy' to be submitted under Horizon Europe.

assistant: **Abstract**

Development of a cure for rare cardiac diseases is a risky, costly and time-consuming process, which is hampered by insufficient insight into pathophysiological mechanisms of the diseases and lack of relevant disease models. The GEREMY consortium proposes to overcome this challenge by developing a gene therapy (GT) for inherited arrhythmogenic cardiomyopathy (ACM), by targeting the disease-causing PLN (non-desmosomes) and PKP2 (cardiac desmosomes) mutations. The GEREMY consortium will apply a unique parallel approach and investigate various promising GT approaches (oligonucleotide chemistries, gene editing and gene delivery). Also, the consortium will engineer disease models for proper assessment of therapeutic interventions and aims to provide in vitro & in vivo preclinical proof-of-concept for the GT.A significant benefit compared to current technologies is that the GT has the potential to be a curative treatment for rare cardiac diseases. Based on previous successes, GEREMY will target PLN & PKP2 as a roadmap of the technology. Restoring the primary defect in the PLN & PKP2 genes that cause the disease will lead to preserving or even restoring myocardial contractility. Through this approach, GEREMY will work towards a curative treatment of inherited ACM and likely other cardiomyopathies, which significantly reduces the healthcare burden. The project’s experts in preclinical research and cardiac genetics will deliver preclinical efficacy and safety data for the mutation correction. The partners with regulatory and clinical trial expertise (EXOM, EUF, NLHI) will prepare for immediate start of clinical trials upon project completion, and apply for orphan drug designation. EUPATI, a patient organisation and KUL ethics partner will ensure that the project is continuously
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Word and the Brain: Rhetoric and Persuasion in Soul and Body' in the context of a Horizon Europe call.

assistant: **Objectives**

The power of words is not a metaphor. The word-and-brain entwinement, part of the mind-and-body relationship, has long been the focus of religious, philosophical, and scientific debates, e.g., on the nature of prayer and meditation. Modern-day psychology and neuroscience are also fascinated by how verbal suggestion affects neuroplasticity and healing. NEUROWORD will present an interdisciplinary and comprehensive historical study of reflections on the impact of eloquent speech on the human body. In the early modern critical scientific context, when the seat of consciousness was transferred from the soul to the brain, I will examine the full spectrum of views on the relationship between the word and the brain across the disciplines concerned with experiences of soul, mind, and body: rhetoric, musicology, preaching, theological anthropology, philosophy, medical psychology, logopedics, and neurophysiology. I will examine not how rhetoric was used in scientific discourse but how it was deemed able to affect the brain. The psycho- and neurophysiology of persuasion can be best explored through the lens of rhetoric, as it was less prone to the mind-body dualism professed by much of the natural philosophy. These matters have not been studied, but by filling this gap, we can gain valuable insights into the entangled history of conceptualization of the mind-and-body relationship. This project is critical at a time when our mediated environments make rhetoric ambiguous with respect to truth and ethics, which demands a historical perspective on the neuroscience of eloquence for an educated approach to scientific communication. At the Warburg Institute, a leading centre for the history of rhetoric and part of the University of London with its range of prominent neuroscience programs,