RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'THE FORMATION and EVOLUTION OF GALAXIES' in the context of a Fourth Framework call.

assistant: **Objectives**

This programme will train 12 young postdoctoral workers in one of the most active areas of astrophysics using technical means ranging from forefront are seen when only a fraction as old as nearby systems. The evolution of instrumentation at major observatories to parallel supercomputers. About 30 the Universe can be studied directly through observation of such galaxies, and this has been a major motivation for the new generation of large PhD students will substantially expand their inter-European research experience through extended stays in partner laboratories. ground-based telescopes as well as for satellite observatories like the Hubble Space Telescope and ISO. We propose a coherent programme to study distant galaxies at optical, infrared, and radio frequencies. This will be coupled to theoretical work on protogalactic collapse, on galaxy evolution, and on the interaction of galaxies with their environment. Our goal is to understand how galaxies formed and how the Universe has evolved over the last 90% of its history. We have already made major contributions to this field including: discovering the most distant known galaxies; proving that the galaxy population is strongly evolving; constructing the most sensitive available infrared spectrographs; developing both the current standard picture of galaxy formation and the best numerical techniques for simulating this process; developing the techniques now used universally to model stellar population evolution. Our programme is based on existing and productive collaborations, many funded under earlier EU programmes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developmental Molecular Pathways in Drosophila as a Model for Human Cancer' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cancer is often characterized as a disease of signal transduction pathways, since it is frequently associated with inappropriate activation of such pathways. Indeed, new therapeutic approaches in cancer therapy, such as Herceptin, frequently target signaling pathway components to revert their pathophysiological aberrations. Most oncogenic pathways have been highly conserved throughout evolution with Drosophila representing a particularly powerful genetic model for the analysis of such signaling cascades. These cancer pathways include Wnt, Notch, Hippo and JAK/STAT pathways. The analysis of signaling pathways in Drosophila is facilitated by the availability of a broad range of genetic tools, a completely sequenced genome and the availability of genome-wide collections of RNAi reagents. Within this project, we will establish high-throughput cell-based assays for regulators of the major developmental oncogenic signaling pathways. Cell-based assays for signaling pathways will be screened using genome-wide RNAi and small molecule compound libraries to identify new components, regulators and targets. Suppressor/enhancer screens in cultured cells will be used to identify small molecular compounds that interfere with the activity of specific signaling pathways and in vivo models of signaling pathways will be established to test the activity of drugs using developmental and tumorogenic phenotypes. By integrating and standardizing data from most important cancer relevant signaling pathways and combining them with powerful bioinformatics tools, we expect to get highly validated information on possible drug targets and lead substances. The collaborative project integrates recent technological advances, such as genome-wide RNAi libraries for cell-based and in vivo assay models that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as drugs against tuberculosis (NEW ANTIMYCOBACTERIALS)' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

A new drug against tuberculosis (TB) will be developed based on the inhibition of the 1-deoxy-D-xylulose 5-phosphate (DOXP) pathway. The DOXP pathway supplies M. tuberculosis with essential isoprenoids. In mammals, the DOXP pathway is absent and isoprenoids are synthesised by the evaluate pathway. Therefore, inhibitors of the DOXP pathway are non-toxic for the human host. Inhibitors of DOXPreductoisomerase (Dry), key enzymes of the DOXP pathway, are to be developed as potential anti-TB drugs. In addition, the crystal structure of the Gape enzyme will be solved to provide the base for future drug development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FGF1: a novel metabolic regulator involved in insulin sensitization and glycemic control' (FGF1T2D).

assistant: **Concept**

Type 2 diabetes (T2D) and obesity are leading causes of mortality and are associated with the Western lifestyle, which is characterized by excessive nutritional intake and lack of exercise. A central player in the pathophysiology of these diseases is the nuclear hormone receptor (NHR) PPARγ, a lipid sensor and master regulator of adipogenesis. PPARγ is also the molecular target for the Thiazolidinedione (TZD)-class of insulin sensitizers, which command a large share of the current oral anti-diabetic drug market. Despite their efficacy in glycemic control, TZDs are associated with various adverse side effects, including weight gain, edema, and liver and cardiovascular toxicity, which limits their clinical use. During my postdoctoral research in the laboratory of dr Ronald M. Evans, at The Salk Institute, I have developed a novel screening tool for the functional analysis of complex transcriptional pathways. Using this technology, we have identified Fibroblast Growth Factor 1 (FGF1) as a novel target of PPARγ. In experiments with FGF1 knockout mice, we further demonstrated that these mice develop high-fat diet induced insulin resistance and hepatic steatosis, underscoring its significance in the development of T2DM. The studies proposed here aim to investigate the pharmacologic effects of FGF1 on energy metabolism and the development of T2D. This novel pathway defines a previously unrecognized mechanism for the insulin sensititizing actions of TZDs. Therapeutic targeting of FGF1 could serve as an improved strategy for the treatment of T2D, eliminating some of the adverse effects of TZDs that are mediated through direct activation of PPARγ.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biomarkers for Animal Vulnerability Assessments' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The Arctic is experiencing the effects of global heating at an accelerated rate, with unprecedented consequences to this uniqueecosystem. As a Pleistocene survivor, the muskox (Ovibos moschatus) is an iconic representative of this shrinking biome. Given theirkey role in tundra ecosystems and their circumpolar distribution, it may act as a sentinel species indicative of biotic change in Arcticecosystems. Due to experiencing multiple bottlenecks historically, genetic variability in the muskox is low and populations may thusbe poorly equipped to adapt to rapid environmental change. Increasing temperatures not only facilitate changing environmentalconditions via a northward shift of infectious diseases, pathogens and vegetation but may also push the limits of the upperthermoneutral zone of muskoxen, causing metabolic stress.BAVA will investigate the vulnerability of muskox populations facing different degrees of environmental stress across its circumpolarrange. Integrating metabolomics in a space-for-time experimental design allows for the examination of the ecophysiologicalresponse of four wild muskox populations to environmental conditions across a vast gradient of environments representing past,present and future Arctic climates, and thus contrasting levels of environmental stress, for a species that is highly adapted to cold anddry Arctic climate.By using a state-of-the-art biomolecular approach, BAVA will identify biomarkers linked to metabolic pathways, describe theirspatiotemporal patterns of variability and utilise this information to inform population-level modelling of population resilience toclimate change. In doing so, BAVA elucidates individual- and population-level metabolic responses to contemporary and futureenvironmental change. Eventually, BAVA will not on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The formation of the state in Early Medieval Castile: craft production and social complexity' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main goal of the project is to analyse the emergency and the collapse of states in the Early Middle Ages through the study of production and distribution systems, which are consider a marker of social and political complexity. The project is based on two main axes: first at all, an interdisciplinary approach to the analysis of pottery would have the capability of revealing the political background of economic exchange. And even if this approach has been successfully applied to the study of process such as the end of the Roman Empire, at the same time our knowledge about the formation of state in South of Europe is very limited. Secondly, the North of Iberia represents an excellent case study for investigating the transformation of political structure in Early Medieval Europe, taking into account that in this scenario five different states rose and collapsed within only five centuries.Production, distribution and consumption systems would be analysed, in order to highlights evidence for social and political complexity related with the emergence of states. In practical terms, early medieval pottery from 14 sites located in the Old Castile would be studied by Dr. Francesca Grassi, PhD on Medieval Archaeology. The main steps of the project would be (a) the identification of the main workshops located in the upper Ebro valley in early medieval times; (b) the analyses of consumption patterns, by combining pottery studies with bioarchaeological and palaeodiet evidence; (c) the definition of political trends at a local scale and the change of scale that determined the structuration of central powers taking into consideration the distribution systems.The results of the Spanish case studies will be discussed with reference to previous studies carried out in Italy by the candi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An integrated approach to understanding the magnetic signal in sediments and its application to sedimentary unconformity 5' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Because rock magnetic methods are comparatively rapid, they are increasingly applied in Earth Sciences providmg a high resolution tool to analyse past environmental and climatic changes recorded in geological materials. For a scientifically correct interpretation, however, potentially biasing diagenetic effects on the (paleo)magnetic signal must be completely understood. The underlying proposal intends to provide an in-depth insight of these diagenetic effects by combing two promising recent approaches, one put forward by me, the other proposed by the envisaged host laboratory. Part I of the work involves the synthesis of these two approaches so as to establish a sound basis for their application to sedimentary unconformities which potentially cause a dramatic, yet unknown, diagenetic alteration of the magnetic signal (part II). The outcome of the research will significantly enhance rock magnetism as an interdisciplinary tool for the analysis of paleo-environment and paleoclimate, including the retrieval of true geomagnetic information stored in the paleomagnetic signal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Silicon technology access to research' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project is aiming to establish a world-wide recognized and unique European-based Research Platform for advanced silicon research and development. The set-up of the overall joint research platform is ambitious and necessary to keep Europe at a world wi de top-level. This will be done by extending the infrastructure within the 300mm compatible process driven research pilot-lines under construction at IMEC, CEA/LETI and FhG-IISB with mainly complementary equipment, and by cross-linking the three new rese arch facilities for an optimized wafer exchange enabling the operation of a so-called ' distributed processing facility'. This European Research Platform will be accessible to the academic research community allowing them to make use of state-of-the-art e quipment in order to boost up their own research programmes and/or enter in joint development programmes. This European global access will safeguard and further strengthen the leading European role in important research fields related to advanced silicon processing, emerging devices and nanotechnology. The final objectives are the enabling of state-of-the-art hands-on training for young researchers, post-docs and senior staff members, the possibility to perform cost effective advanced research and to enh ance the increased mobility of researchers within Europe and from outside Europe towards Europe.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Calibration and integration of peripheral and foveal information in human vision'.

assistant: **Innovation**

Human visual perception is one of the best-studied areas of research on the human mind. However, 99% of that research is concentrated on the central region making up less than 1% of our visual field. This is the region that gets mapped onto the fovea, where vision is best. However, information from the peripheral parts of a scene is highly important. Mediated by attention and eye movements, it is essential for guiding us through our environment. In the brain, the foveal and peripheral parts of the visual field undergo vastly different processing regimes. Since objects normally do not change their appearance, whether we view them foveally or peripherally, our visual system must integrate and calibrate peripheral information before an eye movement with foveal information after an eye movement.We are planning to address these processes in four series of experiments. First, we will study the perception of basic visual features, such as orientation, numerosity and colour across the visual field and their integration in peripheral and foveal vision across eye movements. Second, we will investigate how this integration is supported by attention and memory resources. Third, since the integration requires learning and plasticity, we will track changes across the life span and study how healthy subjects can learn to compensate for artificial changes of peripheral and foveal vision. And fourth, we will explore whether we can manipulate the integration process for the optimal guidance of eye movements in complex natural search tasks. The project will provide insights how the brain achieves a stable and homogeneous representation of the visual environment despite the ever changing sensory input and the inhomogeneity of processing across the visual field. We will reveal the basic lea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social Republicanism in XIXth c. Spain' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The SOCRES project will investigate the ‘Cantonalist’ revolution, a Spanish socio-republican insurrection which burst out in 1873 in Cartagena, a military harbour in the South East of Spain. Though quite similar to the well-known Paris commune (1871), the Cantonalist insurrection was later totally forgotten, in contrast with its French counterpart. By documenting this experience of a social republicanism built ‘from below’, the SOCRES project hopes to shed new light on the history of political thought. It will also challenge the clichés about the political backwardness of Southern Europe and about the political ‘apathy’ of Spanish society till 1931. In the SOCRES project, a strong attention will be dedicated to the role of exiles, deportees, migrants and seamen in the global diffusion of socio-republican ideas at that time. It will lead to a connected history of 19th-c. Spain, showing that political and cultural movements in the metropolis had both roots and echoes in the colonies (mostly Philippines and Cuba), and in the rest of the world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'VISUAL TRUST. Reliability, accountability and forgery in scientific, religious and social images' in the context of a Horizon 2020 call.

assistant: **Objectives**

Our present is immersed in a crisis of trust. This crisis is most evident in the domain of images, which are not perceived as visual evidence anymore. Faketuality, post-truth and misinformation are concepts used to refer to the alleged loss of objective patterns for assessing the truthfulness, accountability and reliability of the information we receive about the world. However, trust is not a matter of all or nothing: it is a contextual relationship, an issue of “ordinary ethics” whose study requires empirical data. Indeed, we must recognise that, despite living in times of (visual) uncertainty, we all still trust some images as mediums for knowing and communicating. But on what basis? VISUAL TRUST is a multi-disciplinary, comparative and innovative project aimed at developing a general theory of (mis)trust in images in the contemporary world. This project will develop an experimental investigation, both on-line and off-line, on how visual trust is crafted, conveyed and assessed. It will analyse the relationships established by individuals from different socio-cultural milieu with: (1) “social images” (documentary and photojournalism; websites of “real” and “fake” news); (2) “religious images” (Hinduism; Afro-American religions); (3) “scientific images” (outer space; inner human body). The project will focus on (a) image-making laboratories, (b) contexts of image circulation and reception and (c) patterns of iconic verification (the models employed to assess the reliability of images). Fieldwork will be carried out in different contexts (internet, worship centres, museums) in Europe, India and the Caribbean, in the vein of symmetrical anthropology. The research will be based on visual methods of which the PI has extensive experience (photo-elicitation, photography, cin