RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Full field high resolution industrial 3D-microtopography' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The research project deals with the measurement and the control of surface roughness on any type of material. Material roughness is often at the root of important applications in many industrial sectors: metallurgy aerospace, automobile, glass, biology, electronics, plastic, etc., where on one hand material roughness is necessary or unavoidable, and on the other hand it needs to be perfectly controlled for efficiency or security purpose. Recent developments in optical roughness sensing open the door to sizable progress in industrial control, with direct impact on product performance/quality and on enterprise competitiveness. The project is about cooperative research for the development of a new type of roughness sensor to allow surface microtopography with accuracy and speed performance levels compatible with industrial requirements for 100% control, and for the adaptation of this basic sensor to industrial applications in four areas: luxury product packaging, glass manufacturing in ophthalmology, high-precision mechanics, medical and paramedical engineering. Specific objectives are to provide instantaneous measure of the microtopography of a surface of any material located within a volume of (x, y, z ) = 670 x 500 x 250 cubic micrometers, with resolutions of 1 micrometer in the x and y axes and of 0.01 micrometer in the z axis, acquisition time less than 1 second, with incoherent white light and CCD matrix detector Another goal of the intended research is to conduct preliminary studies in view of setting standards in optical surface microtopography techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural design of a counter-rotating open rotor' (DECROR).

assistant: **Innovation**

In this project two fe-models for counter-rotating open rotors made from composites are needed. Before generating these models a structural design is necessary. IBK is a SME with a long tradition in both structural mechanics and aerodynamics. Consequently our customers come from areas where both parts of our knowledge are needed, which is among the aviation industry the turbine industry. IBK can therefore draw on long years of experience in the field that is needed here. Therefore a project is proposed, in which the disciplines of designing rotating devices (in this case an open rotor) and designing parts with composites (in this case the rotor blade) are united. IBK will start with an detailed analysis of the design problem of the rotor-blade, propose and discuss solution with the JTI-Consortium and develop a composite-design, using a modern, state of the art failure criterion which promises a high level of quality for the design. All relevant steps will be performed in close cooperation with the contractor, in order to ensure that all input for the project is accounted for.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a bioelectrochemical device for CNS repair' (NERBIOS).

assistant: **Concept**

This project will produce an electrochemical device to induce central nervous system (CNS) repair, based on electroactive materials, electrical field (EF) stimulation and axonal growth promotion. The device will be tested in vitro with cultured cells and brain-spinal cord preparations from amphibians and rodents. Pilot in vivo experiments with a rat model of spinal cord injury will take place at the end of the project. We aim to develop a three-dimensional scaffold (3D-S) with defined structural and electrochemical properties that supports neural cell function, avoids cytotoxicity and inflammation and guides growing axons through lesion sites. The 3D-S will be made from electroactive materials that, besides giving structural support, will permit the application of EFs to promote regrowth of axons and modulate redox reactions in cell/material interfaces. We will focus on organic conducting polymers (polypyrrole) and biodegradable poly-(trimethylene carbonate/e-caprolactone, P(TMC-CL)) copolymers, alone and as composites with titanium and iridium oxides. Materials will be synthesised by chemistry methods that tune the electrochemical potential of the active surface. Material performance will be studied in electrochemical devices with physiological fluids, neural, endothelial and inflammatory cells and CNS preparations. The optimisation of material structure and electrochemical activity will culminate in the production of a 3D-S seeded with neural cells and equipped with electrodes to promote CNS repair. Device configurations with varied stimulating electrode arrangements will be tested. Material surfaces and biomaterial interfaces will be characterized using state-of-the-art technologies including AFM and XPS. Neural responses will be quantified by using fluorescent trace
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Stratospheric ozone: Halogen Impacts in a Varying Atmosphere'.

assistant: **Innovation**

SHIVA aims to reduce uncertainties in present and future stratospheric halogen loading and ozone depletion resulting from climate feedbacks between emissions and transport of ozone depleting substances (ODS). Of particular relevance will be studies of short and very short-lived substances (VSLS) with climate-sensitive natural emissions. We will perform field studies of ODS production, emission and transport in understudied, but critical, regions of the tropics using ship, aircraft and ground-based instrumentation. We will parameterise potential climate sensitivities of emissions based on inter-dependencies derived from our own field studies, and surveys of ongoing work in this area. We will study the chemical transformation of ODS during transport from the surface to the tropical tropopause layer (TTL), and in the stratosphere, using a combination of aircraft and balloon observations together with process-oriented meso-scale modelling. These investigations will be corroborated by space-based remote sensing of marine phytoplankton biomass as a possible proxy for the ocean-atmosphere flux of ODS. From this a systematic emission inventory of VSLS ODS will be established to allow construction of future-climate scenarios. The impact of climate-sensitive feedbacks between transport and the delivery of ODS to the stratosphere, and their lifetime within it, will be studied using tracer observations and modelling. Further global modelling will assess the contribution of all ODS, including VSLS (which have hitherto normally been excluded from such models) to past, present and future ozone loss. Here, the sensitivity of natural ODS emissions to climate change parameters will be used in combination with standard IPCC climate model scenarios in order to drive measurement-calibrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'COURAGE in Europe - COllaborative Research on AGEing in Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The European Commission has identified the challenge of population ageing as the most pressing policy issue in the 21st century. As Europeans live longer and disabilities in this population increase, valid and comparable longitudinal data on their health is essential for evidence based policy making. Valid data requires better measurement instruments and methodologies for longitudinal and cross-population comparative analyses. After an in-depth critique of existing ageing studies, COURAGE in Europe will develop, and validate in three countries, measures of health and health-related outcomes for an ageing population. These measures will be grounded in the WHO’s International Classification of Functioning, Disability and Health (ICF). The ICF offers the only scientifically valid framework for evidence-based measurement of non-fatal health outcomes. We also propose to disentangle the confusion found in current ageing studies between objective states of health and subjective conditions of quality of life and well-being. These elements must be measured independently and against the background of the clear conceptual framework of health. COURAGE in Europe will enhance the scientific study of ageing by developing a tool to demonstrate the relevance to the ageing population of two environmental factors: the built environment and social networks. In sum, COURAGE in Europe is not proposing another ageing study, but the development of a tool to measure of health and health-related outcomes, for an ageing population, that offers objective and evidence-based prevalence trends, and which relates these to both quality of life and well-being outcomes as well as to the role of health determinants such as the built environment and social networks. Understanding ageing and its determinant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineered Porous Electrodes to Unlock Ultra-low Cost Fe-Air Redox Flow Batteries' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This proposal will develop a game-changing paradigm to design, synthesize, and functionalize porous electrode materials with far-reaching consequences in electrochemical science and engineering. Focusing on the Fe-air redox flow battery (FAIR-RFB), which holds promise for low-cost, long duration energy storage, I will employ an interdisciplinary approach bridging (electro)chemical engineering, materials science, and computational design to address the following fundamental challenges: (1) I will elucidate the role of the porous electrode microstructure. I will introduce a new methodology that couples evolutionary algorithms with microstructure-informed simulations to predict ideal electrode geometries. A versatile synthetic platform, non-solvent induced phase separation, will be leveraged to synthesize highly controlled 3D microstructures and train neural networks to accelerate the discovery of optimal geometries. (2) I will determine to what extent surface moieties of the porous electrode influence transport phenomena, kinetics, and durability. I will employ electrografting of select molecules to functionalize porous electrodes and impart functional properties (wettability, activity, stability). I will perform nanoelectrochemical imaging to elucidate the role of electrode-coating-electrolyte phenomena. (3) I will develop a novel electrochemical reactor architecture for high-power Fe-air RFBs. Building upon the two previous developments, I will synthesize tailored iron and air electrodes and leverage polymeric bipolar membranes to realize a high voltage and low resistance electrochemical cell. Advanced imaging techniques, i.e. energy- and wavelength-selective neutron imaging, will be employed to visualize reactive transport phenomena during operation, thus helping to ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SOCIAL ETHICAL AND PRIVACY NEEDS IN ICT FOR OLDER PEOPLE: A DIALOGUE ROADMAP'.

assistant: **Concept**

SOCIAL ETHICAL AND PRIVACY NEEDS IN ICT FOR OLDER PEOPLE: A DIALOGUE ROADMAP (SENIOR) is a 24 month support action which aims to provide a systematic assessment of the social, ethical, and privacy issues involved in ICT and Ageing, to understand what lessons should be learned from current technological trends, and to plan  strategies for governing future trends<br/><br/>There are three main ideas that led the consortium to propose the SENIOR project:<br/>1.\tINCLUSION IS THE GOAL <br/>2.\tDIALOGUE IS THE INSTRUMENT <br/>3.\tDESIGN IS THE TARGET<br/><br/>These ideas generated four strategic SandT objectives:<br/>1.\tDEFINITION<br/>2.\tDIRECTION<br/>3.\tROADMAP<br/>4.\tACTION PLAN<br/><br/>Each of these strategic objective has been encapsulated into specific workpackages and tasks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization of the role of CCBE1 during development and disease' (2007-2013).

assistant: **Innovation**

The lymphatic vasculature is crucial for fluid homeostasis and immune function, and has a central role in many pathological conditions. The molecular mechanisms underlying lymphangiogenesis are poorly understood. Recently, CCBE1 has been identified in the host lab as a key regulator of lymphangiogenesis in zebrafish, mice and human. Importantly, CCBE1 has been associated to Hennekam Syndrome where patients suffer from lymphedema, cardiovascular anomalies and mental retardation.This proposal aims at elucidating the biological role of CCBE1 both on a mechanistic level, but also in biological contexts other than the lymphatic system. To that end, inducible knock out alleles of the mouse Ccbe1 gene have been generated and will be employed in the study, complemented by work in zebrafish embryos. As Hennekam Syndrome patiens suffer from mental retardation, and since Ccbe1 is expressed in the murine cortex, I will analyze neurogenesis in Ccbe1 knock-out mice. In addition to the systemic knock-out of Ccbe1, I will also induce neuron-specific deletion of Ccbe1 by different means. Second, in mutant ccbe1 zebrafish, venous sprouting is severely affected. Recent data show that in Ccbe1 mutant mice there is no ingression of veins into the hindbrain at embryonic day E10.5. Hence, I will analyze this very specific and locally restricted defect, and will also analyze the development of the venous vasculature of the hindbrain of zebrafish. Additionally, I will analyze the role of CCBE1 for venous sprouting in the skin, the retina and the liver of Ccbe1 knock-out mice. Third, mutant knock-in mouse lines will be established that express mutant or epitope-tagged wild type CCBE1 molecules to further characterize the function and distribution of CCBE1 in vivo. In summary, my work will contri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast Biotechnology' to be submitted under Seventh Framework.

assistant: **Abstract**

The YEASTCELL ITN will train 11 Early Stage Researchers for productive careers as research scientists and leaders in the public or private yeast biotechnology sectors. Yeast biotechnology spans fundamental and applied research and is an area with an immediate need for highly trained researchers to advance knowledge and to develop new applications. The training consortium comprises 9 Public Sector (6 Universities, 3 Research Institutes) and 4 Private Sector (2 large companies and 2 SME) partners. A research training programme embracing the philosophy of “use-inspired fundamental research” has been designed to provide all 11 ESRs with interdisciplinary research training in both the public and private sectors. The research themes include yeast physiology and metabolism, metabolic engineering, mathematical modeling, genomics and bioinformatics, fermentation, synthetic biology and systems biology. In addition to training via collaborative research projects, ESRs will participate in courses at local and network levels to enhance their technical and academic skills. All ESRs will register for PhD degrees and will also take a separate postgraduate certificate course in commercialisation and entrepreneurship. Industry-led workshops, research secondments and site visits will provide specific training that prepares ESRs for research in the private sector. A comprehensive programme of advanced training in complementary topics and skills of relevance to both the public and private sectors is provided at the network level. As well as directly training 11 ESRs, the network training activities will provide opportunities for ~40 additional researchers and will promote long-term interactions between research groups at the partner Institutions. The major impact of YEASTCELL will be a coho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'ALOe vera Edible Coating: effective, safe and sustainable post-harvest treatment to enhance shelf-life of vegetables'.

assistant: **Innovation**

The demand of fresh fruits and vegetables is increasing gradually. However, fresh fruit and vegetables are perishable products whose freshness is difficult to maintain along the supply chain. There is a need for reduction of post-harvest food loss by increasing the efficiency of the whole food chain, as one of the first means to fight imbalances and reduce tensions between the increase in food consumption and the challenging increase in food production. At the same time, primary producers are facing the challenge of reducing the use of chemicals to comply with ever stricter regulations. Therefore, there is a market need for 100% organic solutions to increase the shelf life of fresh products and reduce food waste. Among the existing solutions, edible coatings are the most promising to prevent vegetable food-loss and extend vegetable shelf life. However, there are very few solutions free of synthetic additives and suitable for the organic market. To contribute to solve this challenge, we aim to bring to the market our in-house developed product: ALOEco – a 100% organic, effective, safe and sustainable Aloe vera-based post-harvest edible coating. ALOEco extends a 40% the shelf life of vegetables, reducing by 100% the need for post-harvest fungicides, also reducing the energetic requirements for post-harvest conservation, the residue levels on fresh vegetables and the need for synthetic packaging. Our initial sales forecast shows potential cumulative revenues of 12.1 M€ thanks to sales of 4,000 m3 of ALOEco in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Innovative, mechanistic-based strategies for delivery of therapeutic macromolecules across cellular and biological barriers'.

assistant: **Objectives**

Nanomedicine offers capability to significantly change the course of treatment for life-threatening diseases. Many of the most significant current therapeutic targets, to be viable in practice, require the efficient crossing of at least one biological barrier. However, the efficient and controlled crossing of the undamaged barrier is difficult. The range of small molecules that can successfully do so (via diffusive or other non-specific processes) is limited in size and physiochemical properties, greatly restricting the therapeutic strategies that may be applied. In practice, after several decades of limited success, there is a broad consensus that new multi-disciplinary, multi-sectoral strategies are required.  Key needs include detailed design and understanding of the bionano-interafce, re-assessment of in vitro models used to assess transport across barriers, and building regulatory considerations into the design phase of nanocarriers.The overarching premises of the PathChooser ITN are that (i) significant advances can  only be made by a more detailed mechanistic understanding of key fundamental endocytotic, transcytotic, and other cellular processes, especially biological barrier crossing; (ii) elucidating the Mode of Action / mechanism of successful delivery systems (beyond current level) will ensure more rapid regulatory and general acceptance of such medicines. Paramount in this is the design and characterization of the in situ interface between the carrier system and the uptake and signalling machinery. (iii) inter-disciplinary knowledge from a range of scientific disciplines is required to launch a genuine attack on the therapeutic challenge. The PathChooser ITN program of research and training will equip the next generation of translational scientists with the