RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evolution Scenarios for emerging Mobile Commerce services: New Policy, Market Dynamics, Methods of Work and Business Models' (MOBICOM), addressing dissemination and exploitation.

assistant: **Impact**

The MobiCom project will focus on fundamental factors that will affect the evolution of Mobile Commerce, such as market structure, key players, technology architectures, consumer behaviour, new products and services. Towards this direction the project will develop an integrated environment, in order to satisfy the following objectives: * Identification of existing factors deriving from mobile communications and Ecommerce industries, which enable and constrain the development of Mobile Commerce in Europe. *Identification of new factors that emerge due to the convergence of Mobile Telecommunications and Ecommerce technologies and entrepreneurial activities. * Description and specification of new business models and services as well as of diffusion and adoption patterns in Mobile commerce market. * Preparation of guidelines on regulation and policy that may facilitate Mobile Commerce evolution. * Consensus building, dissemination and interaction of Mobile Commerce stakeholdersDESCRIPTION OF WORKThe first phase of our methodology involves socio-economic impact analysis of Mobile Telecommunications and Ecommerce industries. The analysis will be based on quantitative and qualitative methods and will provide the fundamental characteristics of the two industries that drive their evolution and growth. It will cover structural changes, market dynamics, technological evolution, supply and demand sides of the market and consumer profiling. The end of socio-economic impact analysis of existing markets (end of month 4) will be accompanied with the delivery of two reports on the evolution of Mobile Telecommunications and Ecommerce in Europe. These reports will be presented to the project users from telecom and Ecommerce industries in order to evaluate and validate the results. The use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetics of coenzyme Q deficiency in humans' in the context of a Sixth Framework call.

assistant: **Objectives**

Mitochondrial functions are crucial for organism biogenesis development and survival. Their biogenesis and maintenance involve extremely complex processes that require diverse and well-coordinated regulatory pathways. Most of the mitochondrial disorders are due to dysfunction of the respiratory chain. Both mitochondrial and nuclear genomes encode respiratory chain components. Mutations in either genome can cause respiratory chain dysfunction. Coenzyme Q (CoQ) is an electron carrier in the respiratory chain and its deficiency impairs oxidative phosphorylation and causes clinically heterogeneous mitochondrial diseases. Eight genes have been identified in the human genome required for CoQ biosynthesis, although the existence of another genes may be involved. We hypothesize that mutations in any of these genes could cause primary CoQ deficiency and mutations in different genes may explain the clinical heterogeneity of this syndrome. We propose in this project the integration of basic and applied research in a multidisciplinary effort to coordinate the expertise of different European research groups and enterprises. We propose the development of a reliable and easily applicable molecular procedure to reach an unequivocally diagnostic of the genetic origin of mitochondrial diseases that course with primary CoQ deficiency. Research activities are grouped in four work packages (WPs) that will incorporate the scientific objectives. A group of another WPs will include innovation activities such as protection and exploitation of products. Demonstration activities will be carried out in a WP dedicated to the standardization and testing of products. Management will be highly considered by the establishment of internal controls both in science and finances. A special attention will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'CellViewer: super-resolution systems microscopy to assess pluripotency and differentiation of stem cells at single cell level' (CellViewer) targeting Horizon 2020.

assistant: **Abstract**

In this ambitious and multi-disciplinary proposal, we aim to develop new technologies that will allow us to visualize in single cells, in parallel and at the systems level, DNA, mRNAs and proteins with nanoscale resolution. We will refer to these novel technologies as the ‘CellViewer’: a unique cutting-edge high-throughput super-resolution (SR) microscopy approach (including new hardware and software development) to collect at high-resolution a large amount of spatial and dynamic information in single cells. ‘CellViewer’ will allow us to study the mechanisms of mouse embryonic stem cell (mESC) self-renewal and differentiation upon application of specific stimuli, as a specific test case. We will analyse in single cells with high throughput, DNA remodelling at multiple specific gene loci and their corresponding production, distribution and kinetics of mRNA and protein products. We will collect a large amount of dynamic and nanoscale spatial information that will lead us to build predictive models of the phenotypic output from specific input stimuli. In turn, we will be able to develop a mechanistic understanding of how mESCs maintain their stemness or commit to differentiation. The partners of CellViewer are internationally recognized experts from academia and industry in the fields of stem cell and chromatin biology, super-resolution microscopy, quantitative modelling of biological systems, and hardware and software development. This team as a whole is uniquely suited to bring Systems Biology into the era of single cell analysis, which will be a paradigm shift in the way cellular systems will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'From dyke propagation to damage' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content Studies of magma propagation through fractures/dykes are based on linear ela- -sticity. The description of non-linear processes and micro-cracking along dyke walls and at the dyke tip needs to be considered. This requires model- ling the damage. Damage models are applied in geo-materials and concrete structures in Civil Engineering.  Our work will be focused on three closely related issues: 1.The interactions and couplings of damage in rocks and geo-materials, with flows, variations of permeability, and eventually thermal effects. 2.The application of non-local damage models in rocks, with the determination of an internal length characteristic of the material and implied in the models. 3.The inception of fractures, with the localisation of the deformation and damage occuring prior macro-cracking and the associated problem of the bifurcation from micro-cracking to a macro-crack. Training content (objective, benefit and expected impact)  The training will mainly consist of modelling. Special attention will be paid to the implementation of non-local damage models with couplings in finite element codes. Comparisons between theoretical results and observations will be carried out. Laboratory experiments will also be performed. Links with industry/industrial relevance(22) We expect our results have impact in the oil and geothermal industries and in Civil Engineering as well as in Earth sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Purine sensors as novel point-of-care devices for seizures and epilepsy' (ATPsensor) under Horizon Europe.

assistant: **Objectives**

Epilepsy is the most common chronic brain disease, affecting ~70 million people worldwide. Accurately diagnosing epilepsy remains a major clinical challenge due to the lack of non-invasive molecular diagnostic tools. Purinergic signalling via extracellularly released adenosine triphosphate (ATP) and its downstream purine derivatives is increasingly recognised to contribute to increased hyperexcitability states in the brain, and thus seizures. Hence, these can be potentially identified as novel promising therapeutic targets for the treatment of epilepsy but also as a source of disease-specific biomarkers. However, the diagnostic potential of purinergic signalling for epilepsy remains unclear, and current methods of detection are either unsuitable for point-of-care application or lack disease specificity. Employing a multidisciplinary approach including sensor development, testing in preclinical models of epilepsy, and testing in patients, we will develop a new, user-friendly point-of-care sensor which allows the measurement of specific purines and evaluate the diagnostic potential of blood purine expression changes.  Combining my research experience in the development of biosensors with the expertise of my primary (Dr Tobias Engel, RCSI) and secondment (Prof Nicholas Dale, University of Warwick; Prof Norman Delanty, Beaumont Hospital; Prof Felix Rosenow, Frankfurt University) supervisors on purinergic signalling and the development diagnostic devices, ATPsensor will increase our understanding of purinergic signalling and provide new tools to support the diagnosis of epilepsy. The skills acquired during the research project, the excellent training record of the supervisors and host institutions, and the outstanding resources for learning and development available at RCSI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regenerative engineering innovation in early intervention of osteoarthritis' (RENOVATE) under Horizon Europe.

assistant: **Objectives**

Recent breakthroughs in tissue engineering are helping to overcome some severe limitations of osteoarthritis (OA) treatment strategies. Although the latest advances to regenerate cartilage lesions to a healthier state have opened a promising way to prevent joint replacement, current solutions still have a number of challenges ahead to effectively promote satisfactory durable regeneration along the disease progression. With these perspectives, the biomedical engineering market is rapidly growing and demands new knowledge, new skills and new approaches to adapt to the technological evolution of the sector while providing robust products, solutions and treatment strategies which only find a partial match in existing doctoral programmes. RENOVATE addresses this challenge by delivering an innovative multinational, multi sectoral, and multidisciplinary research and training programme in new technologies and novel strategies to produce a new generation of multi-material graded osteochondral scaffolds with a focus on large OC defects. From the research point of view, RENOVATE will integrate data and knowledge to: 1) define patient-specific key functional and mechanical requirements for large osteochondral scaffolds and deliver new therapeutic schemes; 2) enhance the physicochemical and biological behaviour and the mechanical fixation scaffolds; and 3) produce Functionally Graded large osteochondral scaffolds evolving existing 3D printing equipment. With this purpose, RENOVATE’s partnership aggregates relevant scientists from the academic and clinical worlds that will be involved in a high-level personalised training programme that will guarantee fellows and future PhD students outstanding Career Opportunities in the biomedical engineering, orthopaedic sectors and beyond. RENOVA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EXpansion and Phenotype Loss Of SMCs In Atherosclerosis: Causal effects and therapeutic possibilities' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Atherosclerosis is considered an inflammatory disease caused by the accumulation, modification and immune cell recognition of low-density lipoproteins in the arterial wall. Plaque macrophages are held to be the main drivers of disease activity, whereas smooth muscle cells (SMCs) have traditionally been considered protective by forming fibrous tissue that stabilises plaques from undergoing rupture and causing thrombosis.In the present project, we challenge this dichotomous view of cellular villains and heroes in atherosclerosis. Using lineage tracking techniques in mice, we and others have uncovered a large population of SMCs in plaques, which has escaped detection because the cells completely lose conventional SMC phenotype. Strikingly, we have found that the entire plaque SMC population derives from only few founder SMCs that undergo massive clonal expansion and phenotypic modulation during lesion formation. We hypothesise that the balance between the different modulated SMC subtypes and the functions they carry are central to lesion progression. In EXPLOSIA we will address this hypothesis in 3 steps. First, we will conduct a comparative analysis of clonal structure in mice, minipigs, and humans. Second, we will determine links between SMC subtypes, their gene expression programs, and atherosclerotic disease activity by combining single-cell transcriptomics with novel techniques to alter atherosclerotic disease activity in gene-modified mice and minipigs. Third, we will develop techniques for manipulating genes in modulated plaque SMCs and test the causal role of perturbing SMC subtypes and function for lesion progression. The aim of the project is to answer the following key questions for a deeper understanding of atherosclerosis:- What is the clonal architecture of S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functioning of sponge-plant association and responses to ocean warming at the holobiont level' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Seagrass meadows are among the most productive marine ecosystems, playing essential structural and functional roles, and are recognized as the most efficient blue carbon sinks globally. The plant-associated microbiome, a diverse array of microbial taxa forming intimate symbiotic relationships with seagrasses, is critical for maintaining ecosystem stability and facilitating plant adaptation to environmental stressors. In the Mediterranean Sea, however, the endemic seagrass Posidonia oceanica is in decline due to climate change-driven stressors, particularly thermal stress. The sponge Chondrilla nucula is commonly found in association with P. oceanica, and it is hypothesized that this sponge-plant symbiosis enhances the metabolic capabilities of both organisms, mediated by key microbial communities, especially under thermal stress. Despite this potential, the precise dynamics of nutrient exchange and interactions between seagrasses and sponges, facilitated by their microbiomes, remain poorly understood. This knowledge gap limits our ability to fully comprehend the ecological and metabolic functions of these associations and hinders the development of nature-based solutions to mitigate the impacts of climate change. MicroSymb aims to address this gap by studying the P. oceanica–C. nucula association through their microbiomes, utilizing field sampling, mesocosm and stable isotope probing experiments, metabarcoding, and meta-omics approaches. This project will evaluate the capacity of this association to adapt and remain resilient in the face of ocean warming. Throughout MicroSymb, I will acquire advanced skills in metagenomics, metaproteomics, and nutrient cycling within holobionts, while contributing my expertise in marine ecology, host-microbiome interactions, holobiont f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Rational Design of ACAT Single Enzyme Nanogels for Hepatic Fibrosis Treatment-NanoACATre' (NanoACATre) under Horizon Europe.

assistant: **Objectives**

Hepatic fibrosis is a dynamic process characterized by the progressive replacement of functional liver tissue by an extracellular matrix rich in highly cross-linked collagen, with hepatic stellate cells being the main actors of this process. NanoACATre, intended for the treatment for hepatic fibrosis based on augmenting intracellular Acyl-CoA:Cholesterol Acyltransferase (ACAT) in hepatic stellate cells, brings together a talented researcher (Dr. Andoni Rodriguez-Abetxuko), with a background in nanomaterials and biocatalysis, and iNANO-Aarhus University, an innovative and multidisciplinary research institute at the forefront of nanohybrid-based biomedical solutions for liver disease. NanoACATre will focus on advancing the scientific career of Dr. Rodriguez-Abetxuko through the development of new Single Enzyme Nanogels (SENs) for the successful management of cholesterol homeostasis in activated hepatic stellate cells to prevent or reconvert their activation and prevent associated complications such as hepatocellular carcinoma. Under the supervision of Prof. Brigitte Städler, a globally recognized researcher on the field of bottom-up synthetic biology, NanoACATre will proceed in a stepwise fashion using cutting-edge methodologies to prepare and physiochemically characterize ACAT-SENs. The effect of the ACAT-SEN surface physicochemical properties will be evaluated on the ACAT delivery in a rat hepatic stellate cell line. The interdisciplinary work, integrating expertise in polymeric nanogels and protein delivery, will be necessary to achieve NanoACATre's main goal, and the Cell Mimicry Lab, led by Prof. Stadler, is the ideal place to turn this into reality. NanoACATre is designed to broaden the scientific knowledge and transferable skills of Dr. Rodriguez-Abetxuko. In addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Magnetic Properties of Molecular Deposition:low-temperature MFM and nanocalorimetry of sub-monolayers of magnetic molecules'.

assistant: **Innovation**

The controlled aggregation of molecule-based materials in confined geometries has opened a new season in nanomaterials research. The present project is ultimately driven by such a fashionable contest. We propose to experimentally study submonolayers of magnetic molecules, deposited on substrates by chemical methods and dip-pen nanolithography (DPN). The ultimate goal is to detect the magnetic signal from grafted molecules, which are of interest for their potential applications in quantum information processing and magnetic microrefrigeration. We plan to use a magnetic force microscope (MFM), working in the (2.8 – 300) K temperature range and in applied magnetic fields. In addition, we will make use of highly-sensitive sub-1 K calorimeters, whose fabrication by micro- and nanolithography is an objective of the present proposal. The magnetic molecules will be directly grafted on the sensing platform of the calorimeters.The proposed activity will be conducted within the consolidated research group “MolChip”(http://molchip.unizar.es/), by making use of the outstanding scientific facilities available at theInstitute of Materials Science of Aragón (ICMA) and the Institute of Nanoscience of Aragón (INA).