RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Computational characterisation of radiosensitising nanoparticles and their properties'.

assistant: **Objectives**

Coated metal nanoparticles (NPs) in molecular environments are widely studied for applications in nanobiotechnology and nanomedicine. Understanding of the nanoscale phenomena (formation and transport of secondary electrons, free radicals and their chemical interactions) induced by NP irradiation with ion beams is crucial for enhancing the potential of novel radiotherapy techniques. The Radio-NP project aims at the atomistic computational analysis of (i) structural properties of coated metal NPs in biological environments and (ii) the impact of these properties on the formation and transport of secondary electrons and radicals in the vicinity of NPs irradiated with ions. The realised approach will combine (i) the ab initio framework to evaluate parameters of quantum transformations of system constituent molecules, (ii) classical molecular dynamics (MD) employed in the advanced scientific software MBN Explorer to characterise NPs and study their interaction with molecular media, and (iii) irradiation-driven MD - the novel and unique implementation in MBN Explorer, to model random interactions of the medium with secondary electrons emitted from the NPs, with account for possible chemical transformations. The recently developed IDMD approach will be applied for the first time to model irradiation-induced chemistry in the vicinity of complex NPs. This methodology will go beyond the physics of the Monte Carlo approach widely used to study nanoscale mechanisms of energy deposition under NP irradiation. The interdisciplinary research program of Radio-NP will be carried out at MBN Research Center - an SME that develops MBN Explorer software. Radio-NP will combine applicant’s knowledge in radiation physics and chemistry with strong expertise of the host in professional software d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Psychiatric Ratings using Intermediate Stratified Markers - Sofia ref.: 115916' (PRISM).

assistant: **Innovation**

The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has dramatically stagnated in the past decades. In a coordinated effort encompassing academic experts, SMEs, patient and family organizations, regulators, ECNP and EFPIA partners, this project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments for patients. This project will concentrate on Schizophrenia (SZ), Alzheimer’s disease (AD), and Major Depression (MD), as these disorders share part of their symptomatology, in particular social withdrawal and certain cognitive deficits, such as deficits in attention, working memory and sensory processing. By applying innovative technologies (e.g. EEG, cognitive tasks, (f)MRI,smartphone monitoring, and (epi-)genetics) to deep phenotype a clinical cohort of SZ and AD patients combined with a wider analysis of existing clinical data sets from major European and global disease cohorts that also include MD, we will define a set of quantifiable biological parameters best able to cluster and differentiate SZ, AD, and MD patients that do, or do not, exhibit social withdrawal. First, by mining large European SZ, AD and MD cohort datasets with already available social and cognitive proxy measures, and, second, by obtaining objective measures of social exploration levels (using a novel smartphone application), phenotypic relationships with social and cognitive measures will be further tested. For instance we might predict that socially withdrawn individuals may have lower cognitive functioning an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hydrogen-Methanol Ship propulsion system using on-board pre-combustion carbon capture' (HyMethShip).

assistant: **Innovation**

The HyMethShip project reduces drastically emissions and improves the efficiency of waterborne transport at the same time. This system will be developed, validated, and demonstrated on shore with a typical engine for marine applications in the range of 2 MW (TRL 6). The HyMethShip system will achieve a reduction in CO2 of more than 97% and will practically eliminate SOx and PM emissions. NOx emissions will be reduced by more than 80%, significantly below the IMO Tier III limit. The energy efficiency of the HyMethShip system is more than 45% better than the best available technology approach (renewable methanol as fuel coupled with conventional post-combustion carbon capturing).The HyMethShip system innovatively combines a membrane reactor, a CO2 capture system, a storage system for CO2 and methanol as well as a hydrogen-fueled combustion engine into one system. The proposed solution reforms methanol to hydrogen, which is then burned in a conventional reciprocating engine that has been upgraded to burn multiple fuel types and specially optimized for hydrogen use. The HyMethShip project will undertake risk and safety assessments to ensure that the system fulfills safety requirements for on-board use. It will also take into account the rules and regulations under development for low flashpoint fuels.The cost effectiveness of the system will be assessed for different ship types and operational cases. For medium and long distance waterborne transport, the HyMethShip concept is considered the best approach available that achieves this level of CO2 reduction and is economically feasible.The HyMethShip consortium includes a globally operating shipping company, a major shipyard, a ship classification society, research institutes and universities, and equipment manufacturers. Fur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transfer of knowledge in Laser Micro-processing' (LASMICROTOK) targeting Sixth Framework.

assistant: **Abstract**

The knowledge transfer objectives of the project are to:1) introduce to Liverpool a critical mass of external expertise in the field of laser micro-processing,2) train the team of academics and researchers in laser processing at Liverpool in the new techniques,3) develop the basis for long term benefit of the knowledge transfer by a range of measures that will ensure the ongoing viability of the technology at Liverpool,4) establish an enduring network of contacts/ collaborators at project end.This will be implemented by the recruitment of external researchers with the required expertise in laser micro processing from Europe. This will comprise an integrated programme over three years in which key skill requirements will be matched with a suitable range of experience in the researchers appointed. In addition, two visiting professorships of shorter duration will be created to bring in very specific high-level expertise.Existing staff at Liverpool will take part in a structured programme of knowledge transfer, which will involve:1) Lectures and seminars in laser micro engineering techniques, including background theory,2) Hands-on training in the specific micro technologies,3) Joint work with the visiting researchers on real applications development project s with companies,4) Joint dissemination via conference proceedings / journal publications.The new knowledge acquired will have a significant impact on the capabilities of the Laser Group at Liverpool, which will be extended into the new area of laser micro processing. This will allow it to participate in UK national and EU RTD programmes and to form strategic partnerships with large companies and SMEs throughout Europe in the this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Trigger processors and real time event filtering for lhc' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The Centre de Physique des Particules de Marseille (CNRS/IN2P3 and the University of the Mediterranean) is devoted to fundamental research in experimental Particle and Astroparticle Physics. The laboratory is located on the multi-disciplinary fundamental research campus of Luminy, = 10 km south of Marseilles. Presently, the laboratory is involved in major experiments of particle physics: ALEPH (LEP/CERN), H1 (HERA/DESY), D0(Tevatron/Fermilab ), ATLAS (LHC/CERN), LHCb (LHC/CERN) and ANTARES, an astroparticle experiment devoted to the deep-sea, high-energy cosmic neutrino detection. Within its commitments in the preparation of the LHC experiments, LHCb and ATLAS, the laboratory is in charge of the Level 0 Muon Processor for the LHCb trigger system and strongly involved in the Event Filter developments for ATLAS. Triggering and event filtering techniques for the next generation experiments on high energy and high luminosity hadron colliders require advanced technological research and development. Level zero on-line processors must deal with high instantaneous rates and require fast high-density links, very large programmable gate arrays and complex logical and dataflow architectures. This applies to most of the crucial sub detectors such as tracking and vertexing, calorimetry or muon identification devices. On the other hand, high-level event filtering requires the development of large processor farms capable of analyzing at high rates, massive events (using elaborate algorithm for the identification of several physics channels, before storage. Successful applicants will participate in the above research fields. They would be involved in the conceptual design, the simulation, the prototype development and bench testing of fast on-line processors or event-filters. Their wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of mnk1 and mnk2 in cellular regulation' (1994-1998).

assistant: **Innovation**

Research objectives and content The objective of the research is to investigate the role of the recently discovered Erk- and p38 kinase-activated kinases Mnk1 and Mnk2 in the regulation of the physiology of eukaryotic cells. Both Mnk1 and Mnk2 are candidates for key mediators of the actions of multiple signaling pathways. The main goals of the research are: 1. Identifying substrates of Mnk1/2 by: I. screening 1 phage DNA expression libraries with purified active Mnk1/2 in a solid-phase phosphorylation assay. II. the yeast two-hybrid method. 2. Determination under which conditions Mnk1/2 are activated Various cell type/stimulus combinations will be used to study the activation of Mnk1 and Mnk2. For example, we will use human embryonic kidney 293 cells, as data on the activation of Mnk1 are already available and they are readily transfected. 3. Determination of cellular roles of Mnk1/2.By transfection of cells with dominant negative or constitutively active mutants of cells we will study the effect of the kinases on the activity or phosphorylation of substrates, and on cell growth etc.. 4. Determination of the role of Mnk2 in eIF4E phosphorylation.Several approaches will be employed to establish whether Mnk2 is, like Mnk1, able to phosphoryate the key translation initiation factoreIF4E. Training content (objective, benefit and expected impact) The proposed research will substantially broaden the applicant's expertisee. The applicant will learn a range of new techniques, such as protein purification/characterisation and use of dominant negative and constitutively active mutants. This research will especially increase his knowledge and experience in the fast-growing field of signal transduction. The benefits of the proposed research are mainly of fundamental scientific valu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Hot-Spot Bio-Barcode Strategy for Prognostic Biomarkers In Colorectal Cancer' (BioBarPro) targeting Horizon 2020.

assistant: **Abstract**

Colorectal cancer (CRC) is caused by alterations in genes that regulate tissue growth and the risk of developing CRC is influenced by a combination of environmental and genetic factors. Although CRC is often preventable by removing precursor lesions, screening efforts have been hampered by low participation rates and by performance limitations of the screening tools themselves. Detection of blood in faeces is currently the most common screening tool, while stool DNA testing of molecular markers has emerged as a biologically rational and user-friendly strategy for the non-invasive detection of CRC and critical precursor lesions. This advance has significantly increased performance in detecting CRC, but still more than half of the precancerous lesions cannot be detected. The stool DNA test performance for detecting precancerous lesions is expected to be improved substantively by including a completely new type of biomarker, those formed earlier than genetic mutations in the process of carcinogenesis. Such biomarkers are DNA adducts; DNA molecules bound to chemicals.  If not repaired, these DNA adducts generate mutations. Herein, we propose to expand an ERC-funded research result into a kit for measuring CRC-initiating DNA adducts in a stool sample. This kit will enable personalized feedback that quantitatively integrates environmental and genetic factors in colon-cancer associated DNA damage. We have filed a patent application for the chemical basis of the technology and have partnered with an ETH spin-off for the scientific development of our existing proof of principle assay to a prototype kit. In parallel to the scientific work, during the Proof of Concept phase, we will address a phase of the overall commercialization plan that involves licensing the technology to a b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Accompanying Measures to promote IMTs' to be submitted under Fourth Framework.

assistant: **Abstract**

To stimulate transnational exchange of data and methods concerning industrial design promotion, in particular through the creation of practical and conceptual tools.The project includes 4 parts:1. Examination and analysis of the different promotion methods of industrial design for SMEs, used by each contractor, in order to put into action these promotional methods.An Harmonised Method for the promotion of Industrial Design has been drafted including compilation of strategies addressed to encourage the implementation of this Technique in border regions of Belgium, France, Germany and Luxembourg2. Transnational workshops. The 4 themes discussed will be the following:- design and rapid prototyping- design and technology transfer- design and strategy- global designThe first workshop concerning design and rapid prototyping took place in Nancy together with a seminar. 3. Creation and realisation of a CD-ROM intended to promote and introduce industrial design methods in SMEs.4. Elaboration of cases studies directed towards industrial production, with a view to organise training workshops and promotional actions.First case study reported up to date concerns product design by a successful innovative SME.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Continuous Process of the Direct Mechanocatalytic Suzuki Coupling' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The major contribution to chemical waste accumulating in chemical industry is made by solvents – often organic solvents, potentially toxic or harmful for the environment. My ERC-StG Mechanocat targeted this challenge by removing solvents entirely from chemical processes using a concept called mechanochemistry. In Mechanocat I applied mechanochemistry and targeted the famous Suzuki-coupling reaction, being one of the most popular catalysis in chemistry. The breakthrough of the project was the utilization of a principle to this reaction that we denoted as “direct mechanocatalysis” (DM). Applying DM, the catalyst neither must be added as molecule or complex as in homogeneous catalysis nor as solid powder as in heterogeneous catalysis. The milling ball itself served as catalyst because it was made from the catalytic material. This allowed for the easiest ever-possible way of catalyst separation and reutilization – simply taking the milling ball out of the milling vessel. Despite its great economic and ecological advantages, our principle has only been demonstrated on the scale of milligrams using conventional laboratory mills running in batch mode.To advance DM from lab curiosity to true innovation, the ERC-PoC project MechanoExtrusion will thus transfer DM to a continuous process at larger scale by giving the experimental evidence that one of the most popular reactions in pharmaceutical/medical chemistry – the Suzuki coupling – can be conducted in a Pd-coated extruder applying 100 times upscaled substrate quantities. In order to show that DM can become a true alternative to conventional catalysis, MechanoExtrusion will further on quantify the economic and ecological metrics using life-cycle assessment and market analysis, it will target IP protection, create industrial par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Depicting the extraction of cadmea and different mineral “earths” in ancient metallurgy' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Brass, a copper-ziBrass, a copper-zinc alloy, is a major alloy from Roman period and throughout the Middle Ages and early modern period. Despite its importance, relatively little systematic research has been done on its production, and archaeological evidence is less well documented than that for copper and iron smelting. One reason for this is the unassuming nature of most zinc ores and zinc-rich furnace remains, compared to the more easily identified copper or iron slags. DE CADMEA aims first to develop a systematic overview of zinc-rich materials, and related furnace remains from one of Europe's best-studied medieval mining and metallurgical regions, the Harz Mountains, before applying the experience gained onto another important mining region, Cyprus. Little is known about the exploitation of zinc in Cyprus, despite detailed and consistent references in key classical texts to the exploitation of 'earthy substances', described in a way that makes their identification as zinc/brass raw material highly likely, and several indications for zinc-rich smelting remains in the analytical literature. In collaboration with local archaeologists and geologists, the PF will systematically search for evidence for zinc-related metallurgy, broadening the current near-exclusive focus on copper metallurgy in Cyprus. DE CADMEA is an ambitious project producing an up-to-date review paper on historic brass raw materials and production technology, and potentially unravelling a totally new chapter in the metallurgy of Cyprus. The proposal also offers insight into the exploitation of non-standard earthy compounds that may be connected with other types of early metallurgy, such as the silver one. The fellowship is sided with two secondments: the Department of Mining Archaeology in Goslar, fo