RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Disruption of Mucin Glycosylation and Mucus Barrier Function in Response to a Western-Style Diet' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In the healthy intestines, mucus acts as a barrier that separates the host epithelium from the microbiota and intestinal contents, as well as a habitat for commensal microbes. The major component of intestinal mucus, MUC2, is heavily O-glycosylated. Mucin O-glycans are critical for mucus barrier function and host-microbe interactions. Alterations to mucin glycosylation have been associated with diseases such as inflammatory bowel disease and cancer, and represent a novel target for therapeutic intervention. However, studies of the specific glycan structures altered during disease, as well as the consequences of these alterations on mucus barrier function and the microbiota, have been limited by a lack of tools to detect individual glycan epitopes. Mucus barrier dysfunction and microbiota dysbiosis, specifically a shift towards expansion of mucin-degrading bacteria, have been observed in response to a high fat/sugar, low fiber western-style diet (WSD). My preliminary data indicates that a WSD can also alter specific mucin glycosylation patterns. The identification of specific glycan alterations associated with a WSD creates the opportunity to study the role of individual glycan structures in mucus barrier dysfunction and microbiota composition. This study aims to 1) develop novel probes to detect specific glycan epitopes and 2) use these probes to investigate the relationships linking mucus barrier dysfunction, glycan alterations, and dysbiosis in response to a WSD. I will combine my previous experience characterizing glycan alterations in in vivo models of intestinal disease with host lab training in mucus physiology and bacterial enzyme characterization. Findings will advance our understanding of how glycosylation patterns are altered during disease, and how these alte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel dynamic self-assembling system: from hierarchical and biomimetic morphogenesis to functional materials' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

There is great need for radically new paradigms that significantly push forward the complexity, multiscale control, and functionality of novel materials. Molecular self-assembling strategies are continuously being explored for developing ever more precise and organized materials. The development of adaptive materials that can be morphed into complex shapes of hierarchical structure through bottom-up mechanisms that mimic those found in tissue development is a fascinating possibility. This proposal (BIOMORPH) aims to develop a novel dynamic self-assembling material fabrication platform that combines the benefits of molecular self-assembly, bioengineering, nanotechnology, and tissue engineering. The system integrates simple peptide and protein building-blocks with multiple cells types to create complex hierarchical, biomimetic, hybrid structures that exhibit remarkable properties such as self-healing and the capacity to undergo morphogenesis. The work would represent a major step-change by developing a dynamic strategy based on emerging physico-chemical mechanisms that generate and dissipate stresses, and maintain a controlled non-equilibrium state that together is reminiscent of elements found in tissue morphogenesis. The work is divided in four work packages that expand from building block design and synthesis to biomechanical and in vitro assessment of the generated materials. The proposed fabrication platform may find applications in a variety of tissue engineering applications. However, as a first stage, the work proposes to grow tubes and tubular networks that recreate vascular tissue.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Uneven lives: female economy, migration patterns and citizenship in Early Modern Italy' to be submitted under Horizon 2020.

assistant: **Abstract**

FemEcoMig aims to study the connections between migration patterns and female property, work and social networks in Early Modern Italy: it focuses on domestic and international migrations and on female migrants (and their families) who moved to the duchy of Savoy-Piedmont during the period 1650-1800. The project aims to change the common narrative on the history of migration by bringing into the topic a range of historiographical problems that are often considered characteristic of the history of women. It will inquire into the role women's paid and unpaid work and into the use of female property in settlement paths; it will also tackle the extent of female social networks and their use to access to urban resources. The second objective is to analyse the connections between female migration and the achievement of naturalisation. This section will investigates foreign women applying for naturalisation and the reasons for their application. The project will tackle the contents of the grant, and the conditions in which citizenship was enacted and will inquire into the links between migration and settlement paths, economic activities and family strategies.Data will be collected at the National Archives in Turin: two databases will be set up (one for female migrants, the second for people asking for naturalisation), and a sample of migrants drawn from the databases will be the object of biographical reconstruction in notarial deeds. The research will be conducted at the History Faculty of Cambridge University and at the Cambridge Group for the History of Population & Social Structure. The candidate will receive high level and interdisciplinary training to improve skills in data analysis. She will benefit from the host's organisation experience, discuss the qualitative and qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Upgrading of sugar beet pectins by enzymatic modification and molecular farming.'.

assistant: **Innovation**

More than two million tonnes of sugar beet pulp containing 20-25% pectins are generated annually in EU. Due to a poor functional property the pectin cannot be used as a high added-value product. To solve this European problem we want to improve the pectin in the sugar beet plant by molecular farming and down-stream processing. On a short term basis we want to improve the pectin by enzymatic modification. On a medium term basis we want to control the quality of the pectin product by introducing proteins and enzymes, which can modify the pectin in the plant cell wall. On a long term basis we want to isolate the biosynthetic machinery producing the pectin polymer, by purifying the membrane-bound enymes involved in the polygalacturonan synthesis, its methylation and acetylation, and by using Arabidopsis genetics for the discovery of a new genes involved in pectin biosynthesis. In addition we want to determine the structure-functional relationship of a new pectin product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Ultra-lightweight structures with integrated photovoltaic solar cells: design, analysis, testing and application to an emergency shelter prototype'.

assistant: **Innovation**

The introduction of new technologies in the fabrication of light-weight high-performance materials for civil-engineering applications opens many new possibilities for the design of extremely lightweight structures. In particular, the inclusion of photo-voltaic cells together with the use of carbon-fiber cables will allow new design concepts combining an extreme lightness with an excellent structural performance while preserving the sustanability. Even if the new technology constitutes a potential breakthrough, in order to allow a successful impact on the market the properties of the novel materials need to be investigaded in detail so to understand their behaviour with respect to fatigue, aging, or other long-term effects. The wide adoption of such new solutions, will on the other hand imply the definition of an improved computer-based design approach. New tools will be needed to allow modeling to structural behaviour of ultra-lightweight structures and to realize them in conceptual designs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LARGE-SCALE PRODUCTION METHOD OF GRAPHENE TO REACH THE MARKET IN AN EFFECTIVE WAY' (GRAPHENETECH).

assistant: **Concept**

The market for graphene is expected to experiment a great growth in the coming years being applied in a wide variety of sectors (automotive and aerospace industries, advanced composites, among others).Graphene industry will be about 133.77 million € by2020, and up to 440 million Euros by 2024.  However, to reach this estimations there is a need to face the challenges existing today to commercialise graphene: to produce high quality material, on a large scale at low cost, and in a reproducible manner. Most of producers’ retail prices are between 150-230 €/Kg  with only one competitor (from US) in the market offering prices below 100 €/Kg. In terms of capacity, he largest production plant in Europe is limited to 1 Tn.In this context, Eficiencia Energética Aplicada a technological Company supported from 2010 by the Spanish Ministry of Science and Innovation is working to industrialise an innovative and environmental-friendly technology, dry micro-mechanical exfoliation (PCT/ES2016/070058) solution which enables the high quality (95.5%) and large-scale production of graphene nanoplatelets.  Our present objective is to go from a small-scale prototype (20kg graphene nanoplatelets/day) to 280 kg/day in 2018, a required step to ensure industrialisation and standardisation of the large scale production (the largest in Europe with 300 Tn/year in 2022). The work plan proposed by EEA will accelerate the innovation process by up-scaling a single reactor for 20 kg to 70 kg/day and adapting an optimized automation of the process (one rector and 4 reactors working continuously with 280 kg/day). This technological upgrades are crucial to meet expected retail prices and to ensure to European manufactures a large stock of graphene in Europe.Besides, EEA will work in the market implementat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mobilising novel finance models for health promotion and disease prevention' to be submitted under Horizon Europe.

assistant: **Abstract**

In the medium to longer-term, the fiscal space that governments have to provide additional budgetary resources will shrink, including for healthcare. Our response is that it is better to pre-empt rather than repair i.e., to incentivise new ways of financing health promotion and disease prevention. The financing solution is smart capacitating investment. This means sharing risks and resources to invest at scale across multiple levels within health ecosystems generating sustainable returns and localised benefits. The specific objectives are:1.Draw on available evidence to strengthen how smart capacitating investment is framed and communicated2.Assess and enhance organisational readiness for testing SCI models in the regional test-beds3.Develop and test business models that are compatible with smart capacitating investment4.Develop and test novel finance models to determine which of the business models align with pre-defined contingencies for delivering smart capacitating investment5.Develop and test a prototype collaborative platform for governing smart capacitating investment in health promotion and prevention.With an interdisciplinary approach we calibrate and harmonise 3 main work streams: developing functional prototype models of the anchoring concept (smart capacitating investment) [WP2-4]; iterative testing in real world environments (ES,DE,SE,UK initially with an Open Call for a 2nd tranche of transition and less developed regions) to show relevance in tax and insurance-based systems [WP5-6]; preparing a social franchising package for large-scale demonstration [WP7]. Underpinning these workstreams, we will also explore and test platform-based collaborative spaces for the involvement of resourced citizen panels and local communities in planning and investment decisi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Monitoring forests at the management unit level for fire prevention and control' to be submitted under Fifth Framework.

assistant: **Abstract**

The project addresses fire prevention and control in the Mediterranean region. The main focus of this project will be on long-terming fire prevention. Fire prevention, pre-suppression, and suppression all require information on fuelcharacteristrics (e.g. composition, structure, spatial distribution), infrastructure, and terrain (topography). This information is required in a timely and accurate manner, and in a format that is easy to handle and use for integrating into strategic plans for fire suppression management. The information will be designed for the district and sector forest unit level, but be capable of being integrated to higher levels, as necessary. The aim of this proposal will be to create an Internet application to assist forest managers in long-term fire prevention management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Home Plastic-Fibre Networks based on Home Audio/Video Interoperability' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The HOME-PLANET's objective is to demonstrate a consumer friendly In-Home Digital Network (IHDN) that will enhance the consumer's enjoyment and control of entertainment and information. The consortium will demonstrate a user-friendly IHDN solution through a combination of the Home Audio Video Interoperability (HAVi) middleware with its choice of the IEEE 1394 high-speed bus and a plastic optical fibre (POF) physical layer. Through the development of a European source of step index POF (SI-POF) together with the development of high speed resonant cavity light emitting diodes (RCLEDs) and RCLED transceivers, a low cost but high speed (400 Mbps) POF IEEE 1394 based HAVi network will be constructed. The consortium will demonstrate the technology by networking a notebook to a residential gateway and thereby control a digital satellite tuner and home server on the IHDN.Objectives:[1] To demonstrate a consumer friendly In-Home Digital Network (IHDN) based on IEEE P1394.b using Plastic Optical Fibre (POF) and Home Audio Video interoperability (HAVi) middleware. Such networks will operate over 50 m and conform to the Digital Video Broadcast (DVB)-IHDN standard.[2] To Demonstrate a homogenous, HAVi/IEEE1394/POF based application consisting of the remote programming of a home gateway + digital tuner + digital recorder via the Internet.[3] To develop an optical design capability to optimise the entire optical physical layer.[4] To develop low numerical aperture step index POF and thereby demonstrate the potential of 1394 SI-POF networks to operate at S400 over 50 m.[5] To develop 200 Mbps and 400 Mbps 1394 POF transceivers based on 650 nm RCLEDs.[6] To demonstrate a 200 Mbps fully duplex, single fibre link.Work description:The work plan of the HOME-PLANET project rests on several f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cryo analytical microscopy of cell-mediated mineralization in models of bone disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The bone mineralization process is crucial in maintaining the mechanical integrity of bone, from the time of its development to its constant remodeling throughout life. The process of pathologic mineralization and bone remodeling and how cells control these processes, is very poorly understood in vivo. By characterizing unique animal models of bone pathologies, spanning both lack and increase of bone, this project will elucidate the process of cell-regulated mineralization during endochondral ossification, the mineralization process that occurs during growth of long bones, and also during adult remodeling. We will also investigate how a defect in mineralization affects the mineral content, composition and organization of the collagen fibrils and mineral in pathological bones. We will first map healthy (wildtype) mineralization, focusing on the cell regulated mineralization, mineral composition and structure in bone and calcified cartilage. We will then investigate how the cell regulated mineralization alters in hypomineralized bone models, which have been reported as abnormalities of skeletal development. Finally, we will study the bone remodeling in under and over producing bones in leukemia andparathyroid hormone (PTH) treated animal models. To address these problems, this work will combine multiscale, state of the art imaging and analysis techniques from dynamic live animal imaging (cellular level) to spatially resolved nanoscale (mineral and collagen fibrils) analytical techniques to characterize the processes by which bone mineralizes, remodels and also any alterations in these processes between healthy and pathologic tissues. Insight into skeletal cellular mineralization mechanisms in pathologic tissues could guide tissue engineering approaches for restoring bone
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Solid State Chameleons: Chemical Transformations as Single Crystal Transitions'.

assistant: **Objectives**

This project aims to identify and exploit the properties of crystalline molecular materials that lead to single crystal to single crystal transformations (SCSCT). Chemical reactions involving bond formation and breaking generally do not proceed as SCSCT because of the significant structuralrearrangement involved in the process. There exists a small class of compounds for which this phenomenon is observed, however. The observation of a SCSCT implies a highly cooperative solid state transformation from one molecule to another and has fundamental ramificationsfor our understanding of crystal structure. Moreover the fact that a single crystal is produced allows easy characterization of the product by X-ray crystallography. This project will proceed in three stages:1. Design and react:This involve design, synthesis and characterization of compounds directed towards three goal reactions namely addition, substitution and condensation reactions. The Cambridge Structural Database (CSD) will be used to aid the design of target molecules for this reaction by carryingout searches for closely related crystal structures of chemically related compounds.2. Modification:Here, compounds identified as having successful single crystal to single crystal transformations (SCSCT) will be studied in more detail. Small structural modifications will be made to these compounds and their effects on the success of the SCSCT studied.3. Mechanistic studies:Insights will be gained by studying the nature of the SCSCT observed in 1 and 2. The exciting area of SCSCT will bring a new focus to solid state reactivity with the aim of developing a predicate similar to the topological postulate which is used frequently to determine the likely successof solid-state photochemical reactions, with a view to applyin