RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Characterizing the Phase Transitions of Single Organic Aerosols in an Optical Trap'.

assistant: **Innovation**

Organic aerosols play a major role in the chemistry and physics of the atmosphere, serving as cloud condensation or ice nuclei, sites of interfacial chemistry, and scatters and absorbers of incident radiation.  Recent field campaigns have affirmed their prevalence in the troposphere, and aircraft measurements have discovered large quantities of organic material within the nuclei of ice crystals in mid-latitude mixed-phase clouds.  Despite their ubiquity and importance in the environment, little is known about organic aerosols, in particular, their phase state and influence over the partitioning of gas-phase compounds, rate of chemical reactions, water uptake and particle ability to act as CCN or IN. To elucidate the role of organic aerosols, I propose experimental studies on laboratory-generated organic aerosols by investigating their phase behavior under well-controlled, atmospherically-relevant temperature and relative humidity.  For single-particle resolution, I will develop and employ a counter-propagating Bessel beams optical trap (BBOT), equipped with a positional sensor, a cold head (capable of lowering temperatures quickly down to 70 K) and RH control, the first of its kind.  The laboratory-based instrument will be developed in the group of Prof. Ruth Signorell at ETH Zürich, Department of Chemistry, where the research will be performed.  By optically trapping single aerosols and controlling the ambient relative humidity and temperature, the phase behavior of organic aerosols can be characterized, giving insight into their influence on cloud formation, precipitation, and overall climate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Optogenetic investigation of cortical layer-6 neuron contributions to dynamic visual perception'.

assistant: **Objectives**

In order to achieve a more complete understanding of neocortical brain functions in health and disease, we need to delineate the computations of specific cell populations and how they dynamically exert their impact on connected target neurons. Here, I propose to investigate the functions of neurons in layer-6 of primary visual cortex (V1) and their influence on connected neurons, i) in the lateral geniculate nucleus (LGN) of thalamus, and ii) to more superficially located V1 cells, during visual perception in non-human primates (NHP). My core hypothesis is that due to their unique connectivity with LGN on one hand and layer-4 of V1 on the other hand, layer-6 neurons are in an ideal position to facilitate the transmission of visual information from LGN to V1 when spatial attention is allocated to specific visual targets. The central aim of my investigations will be to delineate how the computations and network interactions of layer-6 neurons dynamically change during attention and ultimately lead to improved behavioral performance. To this end, selective targeting and manipulation of LGN projecting V1 layer-6 neurons will be enabled using the methods of optogenetics (ChR2) and viral delivery techniques. Methods to measure brain activity and assess the impact of optogenetic stimulation will include behavioral assessment, functional magnetic resonance imaging (fMRI) and extra-cellular multi-electrode electrophysiology. Data analysis will include measures of directed (functional and effective) connectivity and en-/decoding approaches using a (predictive coding) Bayesian inference framework. With this approach we will gain new insights into the basic principles of information flow in the visual system. Beyond their immediate impact on basic science, the results of the experi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dissecting hepatocyte heterogeneity in liver growth to devise liver gene therapies for pediatric patients' under Horizon Europe.

assistant: **Concept**

In vivo genetic engineering of hepatocytes may represent a definitive cure for monogenic metabolic diseases. Integration of the therapeutic transgene into the target cell genome is essential for long-term expression after a single dose early in life and can be achieved by semi-randomly integrating lentiviral vectors or site-specific genome editing. Maintenance of the genetic modification upon hepatocytes proliferation in liver growth and turnover requires targeting the cells underlying these processes. Little is known about post-natal liver growth and how different hepatocyte subsets contribute to it. Unexpectedly, we found that most hepatocytes are quiescent during liver growth, and a fraction of them generate most of the adult tissue. The overall goal of HEPAGENE is to dissect hepatocyte heterogeneity in post-natal liver maturation and unravel its implications for in vivo gene engineering, to ultimately design and develop safe, effective, and durable gene therapies to treat diseases of hepatic metabolism in pediatric patients. To achieve this goal, we will: i) characterize molecular programs of proliferating and quiescent hepatocyte subsets; ii) assess their susceptibility to lentiviral gene transfer and nuclease-mediated gene editing, in both normal mice and in a disease model of methylmalonic acidemia, a severe early-onset disease, taken as paradigmatic of inherited metabolic diseases; iii) estimate clonal dynamics of genetically modified hepatocytes in vivo in non-human primates and analyze gene signatures in human liver samples, to establish a correspondence between murine and primate’s hepatocyte subsets. We will exploit state-of-the-art organoid, single-cell and multi-omic analyses including latest-generation spatial transcriptomics. HEPAGENE will lead to improv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SMart weArable Robotic Teleoperated Surgery' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Robot-assisted minimally invasive surgery (RAMIS) offers many advantages when compared to traditional MIS, including improved vision, precision and dexterity. While the popularity of RAMIS is steadily increasing, the potential for improving patient outcomes and penetrating into many procedures is not fully realised, largely because of serious limitations in the current instrumentation, control and feedback to the surgeon. Specifically, restricted access, lack of force feedback, and use of rigid tools in confined spaces filled with organs pose challenges to full adoption. We aim to develop novel technology to overcome barriers to expansion of RAMIS to more procedures, focusing on real-world surgical scenarios of urology, vascular surgery, and soft tissue orthopaedic surgery. A team of highly experienced clinical, academic, and industrial partners will collaborate to develop: i) dexterous anthropomorphic instruments with minimal cognitive demand ii) a range of bespoke end-effectors with embedded surgical tools using additive manufacturing methods for rapid prototyping and testing utilizing a user-centred approach, iii) wearable multi-sensory master for tele-operation to optimise perception and action and iv) wearable smart glasses for augmented reality guidance of the surgeon based on real-time 3D reconstruction of the surgical field, utilising dynamic active constraints and restricting the instruments to safe regions. The demonstration platform will be based on commercial robotic manipulators enhanced with the SMARTsurg advanced hardware and software features. Testing will be performed on laboratory phantoms with surgeons to bring the technology closer to exploitation and to validate acceptance by clinicians. The study will benefit patients, surgeons and health providers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving cold chain logistics with a temperature monitoring label' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The pharma and food logistics sectors lose sector lose €31.2bn and €27.6bn a year respectively through poor temperature control in the while in transport. Excessive heat or cold during transit can degrade pharmaceuticals or render them useless, and make highly perishable foods inedible or potentially hazardous for consumers.Logistics companies invest €33bn each year in IoT technologies for temperature monitoring. But current solutions still use costly and cumbersome data logging technologies, with limited or no data analytics capacity, low automation and irregular RFID communication.Svalinn is a automatic temperature logger for land, sea and air logistics. It gives a full temperature and geolocation log on each package or shipment from the start to the end of the transit, with programmable intervals and temperature alert thresholds.


**Keywords:** Cold chain monitoring, multimodal logistics, IoT technologies, cellular networks, printable temperature logger, food safety, pharma safety, automatic, customisable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Deciphering the sense of smell in the invasive pest Drosophila suzukii'.

assistant: **Concept**

The spotted wing drosophila, Drosophila suzukii, is an invasive polyphagous pest endemic to South East Asia. It has recently invaded western countries where it has become a threatening pest for cultivated small fruits. Unlike most others Drosophila species, whose larvae feed on decaying plant, D. suzukii lays its egg on unwounded ripening fruits. Host selection arises from oviposition behaviours of adult females, which detect chemosensory inputs, in the form of plant airborne kairomones, to locate fruits suitable for oviposition. Therefore, it is of great interest to elucidate the molecular basis of olfactory-driven behaviours that D. suzukii has evolved in comparison to Drosophila non-pest species, particularly understanding mechanisms of host fruit selection. The aim of this proposal is the identification and characterisation of olfactory receptors in D. suzukii. The methodology is based on a multidisciplinary approach that combines comparative genomics, transcriptome analysis and functional characterisation of olfactory receptors. D. suzukii gene families encoding olfactory receptors will be compared with those of two non-pest Drosophila species (D. subpulchrella and D. biarmipes, both belonging to the suzukii subgroup) to identify unique D. suzukii genes. Transcriptomic data will be generated to compare the expression profiles of D. suzukii gravid females versus adult males to identify transcripts potentially involved in sex-specific behaviours. Unique D. suzukii genes specifically expressed in gravid females and codifying for odorant receptors (ORs) will be characterized by using the Drosophila melanogaster “empty neuron” system that has proven to be successful in coupling olfactory response to OR genes. With the proposed project, we are confident to gain insight i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TRA VISIONS 2020' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The scope of this proposal, as requested by the call, is to organise two competitions for transport research awards to be announced at the TRA conference in 2020:- a young researcher competition with the goal of stimulating the interest in the field of sustainable transport among young researchers and students.- a competition for senior researchers in the field of innovative  transport concepts based on results only from EU-funded projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Addressing vaccine hesitancy in Europe' (VAX-TRUST) under Horizon 2020.

assistant: **Objectives**

Distrust of expertise represents  a great challenge for modern societies. In particular, it creates difficulties for healthcare professionals, given that citizens are arriving at the consultancy room with ready-made diagnoses, internet misinformation and contested attitudes. Vaccine hesitancy epitomizes this contestation: some parents refuse to vaccinate their children which leads to low vaccine coverage and risks of disease outbreaks. VAX-TRUST will contribute to increasing vaccine uptake in Finland, Belgium, Poland, Czech Republic, Italy, Portugal, and the UK and Europe as a whole by: 1) equipping healthcare professionals with tailored up-to-date knowledge on vaccine hesitancy in their specific local region and nation in international perspective; this knowledge will be obtained through (a) critical review of previous research on vaccine hesitancy, (b) a quantitative study using existing Eurobarometer 91.2 data (n=27,524 in 28 countries), (c) a quantitative and qualitative media analysis during 2019-2021 and (d) qualitative observations and interviews with healthcare professionals and parents (n=60 per region) at local healthcare centres in specific Target Regions;2) giving healthcare professionals tools, support and peer support to deal with vaccine hesitancy, taking into account that some professionals may themselves be vaccine hesitant. This will involve specific interventions tailored for the Target Regions and include 50-100 individuals. These interventions will be evaluated for usability and transferability;3) distributing the intervention tools to future healthcare professionals in order to strengthen their knowledge about vaccine hesitancy and facilitate support to meet with vaccine hesitancy in their future career; exploitation events will aim at 50-100 medic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Model Atmospheres of the Progenitor Stars to Supernovae and Black Holes:  Finally in 3D!' (SUPERSTARS-3D).

assistant: **Concept**

Stars with masses many times that of our Sun are the direct progenitors to cosmic phenomena such as supernova explosions, black holes, and gravitational wave (GW) sources. Through electromagnetic observations we obtain empirical information of such massive stars, however decoding the radiation reaching us through our telescopes is a highly non-trivial exercise. To constrain fundamental properties like temperatures, radii, chemical abundances, and mass loss, the observed radiation is fit by means of model stellar atmospheres. Observations and theory show that the radiation-dominated atmospheres of massive stars are highly complex, multi-dimensional systems. However, although 3D model atmospheres of sun-like stars have already been on the market for a while, for hot, massive stars we still rely solely on results derived from inadequate 1D simulations. This severely limits our knowledge of the basic physics of massive stars and our capacity to correctly interpret observations, thereby preventing progress also in the large number of astronomical fields (e.g., black hole and GW progenitor models) that rely on a firm understanding of the massive-star life-cycle. The time is now ripe to change this.Building on the unique expertise of the PI and his team, in a groundbreaking effort we will here develop the very first 3D model atmospheres for hot, massive stars with winds. SUPERSTARS-3D will fundamentally improve our physical understanding of massive stars, and revolutionize analysis and interpretation of their observed radiation. By further confronting our pioneering simulations directly to state-of-the-art observations, we will derive unprecedented constraints on evolution and end-of-life models. We will develop all new models in an open-source fashion and make them easily acc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Twinning Open Data Operational' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project ""Twinning Open Data Operational"" (TODO) aims to leverage the interdisciplinary scientific excellence and innovation capacity of the University of Zagreb (UNIZG) in the field of open data to boost the supply and use of open government data in Croatia and beyond. Open data initiatives have resulted in greater availability of data, thereby realising ambitions such as improved efficiency and effectiveness of public services, increased transparency, accountability and citizen participation, and economic and social value creation. Open data research is a crucial component in creating and accelerating sustainable and innovative open data ecosystems. However, open data and open data research in Croatia are still in its infancy. With the support of key organizations in the Croatian open data ecosystem and esteemed national and international experts, TODO will enhance the research capacity and research excellence in open data research of UNIZG and its staff through the partnership with two leading universities in the open data domain, University of the Aegean (UAEGEAN) and Delft University of Technology (TUDELFT). TODO will develop and implement an interdisciplinary multi-domain open data research approach to increase the maturity of the concept and impact of the open data ecosystem in Croatia and beyond. The activities directed at training, knowledge exchange, collaboration, outreach and long-term sustainability should establish an internationally leading open data research ecosystem at the UNIZG. Through research, TODO will explore the gaps between supply and demand of open data and build understanding of an open data ecosystem in Croatia. Participation in existing international networks, together with the newly built scientific excellence and innovation capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PHev towards zerO EmissioNs & ultimate ICE efficiency'.

assistant: **Innovation**

PHOENICE aims at developing a C SUV-class plug-in hybrid (P1/P4) vehicle demonstrator whose fuel consumption and pollutant emissions will be jointly minimized for real world driving conditions. This development will require the optimisation of a highly efficient gasoline engine, relying on a dual dilution combustion approach with excess air and EGR, synergizing an innovative in-cylinder charge motion with high pressure injection, novel ignition technologies, and an electrified turbocharger particularly relevant for hybrid architectures. The potential of alternative fuels produced by P2X processes will also be considered. To achieve the targeted near-zero emissions in transient conditions specific to PHEV in real driving conditions, the demonstrator vehicle will be equipped with a complete and dedicated after-treatment system including an electrically heated catalyst, a SCR and a GPF for abating NOx, particle number down to 10 nm, and non-regulated gaseous emissions.The vehicle overall efficiency will be increased with an exhaust waste heat recovery system for generating an additional electric power contribution for cabin heating or cooling, or for reducing the switch-on time of the internal combustion engine in cold conditions, thereby limiting the engine-out pollutant emissions such as particles. Virtual methods will be employed to reduce the calibration time of all the vehicle sub-systems. The vehicle control will use all the flexibility of the hybrid architecture and sub-systems to lower in real time the driving emissions and fuel consumption.Technologies developed in PHOENICE will achieve a TRL 7 paying a specific attention to cost, industrialization, and to the use opportunity for various vehicle classes so as to maximize the economic and environmental impacts. Thi