RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'MULTIFUNCTIONAL LAYERS FOR SAFER AIRCRAFT COMPOSITES STRUCTURES'.

assistant: **Concept**

The use of composite materials in aeronautics industry has increased constantly over the last 35 years, due mainly to their high specific strength and stiffness combined with the possibility of designing complex geometry components that are more aerodynamically efficient than metals. But due to organic nature of polymeric matrix component, composite materials are electrically and thermally bad conductors and they tend to burn easily, emitting toxic gases and smoke. For that, they require affordable, effective and certifiable protection systems against atmospheric hazards such as icing, as well as fire and burning in case of accidents.  Moreover, improved in field inspection techniques are required with the increased use of composite materials. Current technologies address those issues separately; ice protection is usually performed by mean of a metal mesh or foil incorporated into the outer ply of fabric on the skin of the structure, fire protection is performed with thermal barrier coatings on the structures and life monitoring is performed with embedded sensors. All of them add high weight penalty and complexity during the component manufacturing and posterior maintenance, even may go against the structural integrity of the component in some cases. LAYSA project aims for a new multifunctional layer to be integrated into composite structures, with ice and fire protection capacity. This can be achieved by integrating nanomaterials (NMs) such as Carbon Nanotubes (CNTs) or Carbon Nanofibres (CNFs) within a polymeric matrix, so that the whole nanocompoiste can be integrated in the composite structure like a layer. The direct benefits of the proposed application include: a) Improve aircraft safety and security, b) Structural weight reduction and simplification of manufactur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The Evolutionary Degeneration of Pollen in Asexual Dandelions'.

assistant: **Objectives**

Dandelions (Taraxacum agg.) are one of the most important plants for insects, providing up to 80% of early spring pollen production in meadows. This high pollen production is surprising and unfavourable from the plant’s perspective as most dandelions reproduce asexually (apomixis). Decreased selection on nutritious pollen is therefore expected and would lead to lower production and degenerate (poor) pollen, or even complete male sterility, in the absence of sex. This would have potentially disastrous consequences for the dependent insects, especially in areas of higher latitude (e.g. Sweden) where sexual dandelions are absent. Little is known, however, about the evolutionary effects of asexuality on pollen production, particularly from a genomic point-of-view.We aim to understand how pollen degenerates under asexuality through a combination of phenotypic and genotypic characterisations in sexual and asexual dandelions, including male sterile plants: 1) microscopy and flow cytometry will reveal the effect of asexuality on pollen number, morphology and viability; 2) comparative transcriptomics in pollen, petals, bracts and leaves will reveal pollen-specific genes and if they are down-regulated under asexuality; 3) comparative transcriptomics in anthers will reveal genes necessary for healthy pollen production; 4) comparative genomics using full gene sequences will reveal the rate of deleterious mutation accumulation in pollen-specific genes, for which museum specimens will be unlocked using a customised Hyb-Seq approach. The fellow will fill significant skill gaps in their career through training in gene expression studies, whilst establishing themselves in plant reproductive biology.NoSexPoorPollen will be the first study to compare pollen gene expression in sexual and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Laser Induced Breakdown Spectroscopy for identification of Aerospace Composites', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In the coming decades thousands of aircraft are due to be retired and dismantled. Other than components to be re-used, substantial parts of aircraft are stripped and shredded. Whereas todays technologies such as XRF work well in many respects, XRF is unable to properly identify aircraft composites, penetrate coatings and XRF is also costly.This proposal will modify and refine LIBS spectroscopy devices to demonstrate their capability to robustly identify aerospace composites, also when subject to ageing and coating.LIBS is a well-established spectroscopy technique outside the aerospace domain. It works by shining a laser beam on a sample, and identifying the atomic emission.TNO has access to a handful of different LIBS devices to perform the feasibility study. To enforce industrial, economic and operational realism, we are bringing companies AELS and Avantes as subcontractors. Both are very active and well-established in European recycling networks. TNO also brings a relevant industrial network to support further industrial development of a portable LIBS device.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FlowAssist Pouch will help to improve the skin condition of ostomy pouch users, while introducing novel design features, dramatically improving their lifestyle and management of their condition' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Ostoform has developed and patented a new Class I medical technology – FLOWASSIST – by combing a non-absorbent material with an absorbent material (hydrocolloid). The non-absorbent material comprises a flexible spout, positioned beneath the patient’s stoma and is combined with hydrocolloid adhesive to keep the spout in place. This hybrid design directs stoma output away from the patient’s skin and into the pouch. The spout prevents output from being absorbed so the hydrocolloid material does not break down. This means that the appliance lasts for longer, the skin is protected for longer and the risk of leaks and skin complications is significantly reduced.The Ostoform Seal with FLOWASSIST has been successfully developed and commercialised through the H2020 SME Instrument. Ostoform now plans to develop the Ostoform Pouch with the same FLOWASSIST technology. As the ostomy pouch market is larger than the seal market, the novel pouch will increase market opportunity and company value.


**Keywords:** Ostomy patients ,Stoma care ,ostomy pouch,hydrocolloid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Beyond neuroInflammation: new Concepts to Elucidate the immune system’s vital role in Parkinson’s disease'.

assistant: **Innovation**

Decades of research into Parkinson's disease (PD) have fallen short in fully comprehending its mechanisms, leaving us without a cure. Current treatments merely alleviate symptoms temporarily, but are unable to impede the progression of the disease. Clearly, PD research has hit a wall, and new approaches are needed. Recent discoveries of the involvement of the peripheral immune system in PD have sparked a groundbreaking proposition by BICEPS: PD must be considered a systemic disease with an immune response involving both brain and periphery. Thus, to revolutionize PD research, we must shift away from the neuro-centric approach of past decades and extend our focus to studying the immune system outside the brain. Furthermore, recent advancements, such as systems biology and artificial intelligence (AI)-driven data mining, diagnosis, and drug development, hold significant promise for advancing PD research.Therefore, BICEPS is uniting PD researchers, immunologists, and experts in AI and systems biology from leading European academic institutions, startup companies, and established pharmaceutical firms into a unique consortium. The primary objective is to train a new generation of PD researchers with interdisciplinary expertise in these fields.This ambitious goal will be realized through an intensive training program that encompasses cutting-edge methodologies, encourages innovation, nurtures transferable skills, and provides immersive, hands-on research experiences. Thereby, the BICEPS network aims to shape the future of PD research by adopting a fresh perspective and expediting the development of diagnostics and therapies for PD, with a particular focus on the immune system.


**Keywords:** Peripheral immune system, Macrophages, T cells, Parkinson's disease, Disease mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Under the light of electrons'.

assistant: **Objectives**

Here, we propose to explore and characterize new emerging phenomena in low dimensional (LD) and artificially structured oxide based systems by means of advanced electron microscopy techniques. Complex oxides have a large range of applications, since their properties change drastically as their precise composition and structure changes. When obtained in LD configurations new functionalities arise which are of fundamental interest in electronics, spintronics, energy or nanophotonics. We will use atomic resolution imaging and spectroscopy in the aberration corrected electron microscope to map their electronic, optical and magnetic properties by means of electron chiral dichroism. We intend to combine spectroscopic magnetic imaging with plasmonic measurements in order to explore, for the first time ever, the sensitivity of electron spectroscopy to magneto-optical properties at high spatial resolution. Our scientific mission will be to a) synthetize and characterize high quality oxide based LD systems and develop new imaging techniques, in order to b) explore new phenomena in systems showing unexpected behaviors. Our approach relies on comprehensive studies with atomic resolution, in real space, and when possible, at work (under the relevant temperature or pressure conditions). We will combine experiments with theory in order to interpret results and design new avenues to follow. This proposal has also a dual strategic component: 1) to create a new group in Spain devoted to study materials physics in such a way, and 2) to establish a world-class collaboration connecting the group to established growers and theorists, assembling a multidisciplinary team. The potential payoffs we envision are large, and many new and unusual materials, devices and phenomena are anticipated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'RAPID IMMUNOCHEMICAL TEST METHODS FORMING A SCREENING SYSTEM TO MONITOR PESTICIDE AND ANTIBIOTIC RESIDUES IN FOOD AND FOOD PRODUCTS'.

assistant: **Innovation**

As the routine analysis of pesticides and antibiotic residues in food, soil and water is expensive and labour intensive there is an urgent need for rapid and sensitive methods that have high impact on commercial competitiveness and exploitation possibilities of industries in the European Communities. Driven by this need major efforts have been initiated for the development of immunochemical methods for these applications.This research project aims at the development of screening systems consisting of rapid immunochemical test methods, simple sol particle immunoassay (SPIAs) and more; sophisticated immunobiosensors, to monitor pesticide and antibiotic residues in food and food products. This specific combination of test methods ensures the possibility to monitor residues throughout the production chain, irrespective of the skills of the person performing the test and also irrespective of the level of laboratory equipment available.Specific poly- and monoclonal antibodies will be raised against six organophosphorus pesticides and against the group of B-lactam antibiotics. In addition, generic antibody preparations, raised for example by immunisation with a chemical structure common to all members of a particular pesticide or antibiotic group, will be developed. In this respect, an important part of the project is the development of single-chain variable region recombinant antibodies, of which specificity and/or affinity can be manipulated by molecular biological techniques. The manipulation of specific, recombinant antibody fragments will be guided by molecular modelling of the binding sites to predict relevant amino acid changes in view of the binding specificity/affinity adaptation required. The application of these flexible antibody fragments in rapid diagnostic test m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Antiviral peptides blocking herpes simplex virus type 1 entry into cells' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The objective is to produce anti-herpes simplex virus type 1 (HSV-1) peptide pharmaceuticals that lock entry of HSV-1 into target cells. Preliminary data have identified several putative lead peptides, but using viral mutagenesis, synthesis of overlapping peptides from each of four HSV-1 surface glycoproteins, a set of lead peptides will results. The latter will be modified by modern peptide pharmaceutical procedures to improve their activity-stability-delivery" profiles. Both in vitro and in vivo assays will be used to rank activity of these modified peptides. It is proposed natural and modified anti-herpes peptides will be used alone or in combination with nucleoside anti-herpes pharmaceuticals to reduce infection times, overcome resistant strains and alleviate the more severe HSV-1 symptoms such as pain, blindness and herpes encephalitis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bifidobacteria as a model system for host-microbe interaction'.

assistant: **Concept**

Our bodies are home to a staggering collection of microbes with the human gut contains up to 2 kilograms of microbial mass. In healthy individuals the interplay between the immune system and the microbiota prevents tissue damaging inflammatory responses to commensal species of bacteria while permitting immune responses against infectious microbes. Changes in the gut microbiome have been linked to perturbation of immune function and several inflammatory gut disorders. Conversely, commensal microorganisms with purported health promoting effects (probiotics) have been implicated as potential therapeutics for several ailments with over 1,300 registered clinical trials using probiotics. Bifidobacteria, a Gram-positive commensal accounts for 475 of these trials. Bifidobacteria colonise the gastrointestinal tract immediately after birth and affect the maturation of the host’s immune system. Despite the impact of microbes on our health and the large number of clinical trials underway, our current knowledge of the impact of the microbiota, including probiotics, on health is based almost exclusively on descriptive and correlative studies with a need for studies focused on causality and mechanism. The central goal of this project is to understand the mechanisms by which Bifidobacterium breve induces an anti-inflammatory and anti-microbial state in host immune cells and to determine if this can be replicated using a synthetic biology approach. The ability of a range of commensals to elicit immune modulatory responses will also be studied to identify shared mechanisms of host-microbe dialogue across bacterial species. A thorough understanding of host-microbe interactions that lead to a tolerogenic, anti-inflammatory, and anti-microbial phenotype will aid in the development of novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Imaging, characterizing and targeting metastatic niches in melanoma'.

assistant: **Objectives**

Melanomas are the only tumors where lesions barely over one millimeter in depth can be at risk for metastasis. An increasing number of (epi)genetic alterations and mechanisms of immune evasion have been identified in this disease. Nevertheless, no molecular biomarker has been approved as a bona fide prognostic indicator. Progress in this field has been hampered by the paucity of models to visualize premetastatic niches in vivo, and monitor relapse after surgery. We have overcome these limitations by generating reporter mouse strains to “illuminate” premetastatic niches. Specifically, our “MetAlert” mice were designed for whole-body imaging of the aberrant expansion of the lymphatic vasculature, an early event that precedes metastasis. MetAlert, together with functional studies in human cells and histopathological validation in clinical biopsies, revealed the growth factor MIDKINE as a new melanoma-secreted prometastatic driver. We have now discovered roles of MDK as an immune suppressor, and identified a MDK-associated transcriptional profile that separates patients with a distinct expression of alarmins and bacterial response factors. Proteomic analyses revealed a set of additional factors secreted by aggressive melanoma cells, but their specific contribution to premetastatic niches is unclear.   Here we will exploit our MetAlert and novel imaging reporters we have generated for a comprehensive spatio-temporal and functional analysis of premetastatic niches in vivo (including and beyond MDK). We will define how melanomas act “at a distance” before metastasis (Aim 1), and evade the immune system at different anatomical sites (Aim 2). Aim 3 will dissect the impact of the microenvironment, particularly via alarmins.  Aim 4 will pursue the therapeutic targeting of metastat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Peroxy radical initiative for measurements in the environment.' (1994-1998).

assistant: **Innovation**

Hydroperoxy radicals (HO2 ) and organic peroxy radicals (RO2) play important roles in the production and loss of tropospheric O3 the formation of other secondary photooxidants such as peroxides and organic nitrates and in the night-time production of OH radicals and decomposition of PAN. Their ground-based measurement may be made using 4 techniques: (i) Modulated Chemical Amplification (MCA) which utilises modulated chemical amplification of NO2 by HO2 radicals in the presence of NO and CO, with RO converted to HO2 via reaction with NO and O2; (ii) Matrix Isolation/Electron Spin Resonance (MIESR) in which HO2, CH3C(O) O2 and RO2 are quantified by ESR spectroscopy after being isolated in D2o matrices at 77K; (iii) Fluorescence Assay with Gas Expansion (FAGE) and (iv), Laser-Induced Fluorescence (LIF) two almost identical techniques whereby HO2 is reacted with NO to form OH radicals, which are then detected by LIF spectroscopy. Each technique currently suffers to different degrees from uncertainties and limitations: inlet system losses and production of radicals (particularly OH and HO2), calibration methodologies for OH, HO2, CHlO2 and CH3C(O)O2 and NO2, relative sensitivities of detection for OH, HO2 and RO2, and corrections for positive interferences such as inlet decomposition of PAN, PNA (peroxynitric acid) and H2O2. PRIME proposes to address these uncertainties and limitations of the MCA and FAGE/LIF techniques for measurements of peroxy radicals in the troposphere through concerted laboratory, field measurement and numerical modelling studies. The aims and objectives of PRIME are: - to carry out a programme of laboratory and modelling studies in order todevelop improved instrumentation for ground-based or airborne measurementsof HO2 and RO2 in the troposphere. Nove