RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Entangled Twin Atom Beams' in the context of a Horizon 2020 call.

assistant: **Objectives**

Many of the fascinating phenomena predicted by quantum mechanics, like non-local correlations and entanglement, were implemented with photons in the framework of quantum optics. It is today a mature field with applications emerging in cryptography, random number generation, and quantum computation.  Based on the analogy between matter waves and electromagnetic waves and on particle-wave duality, quantum atom optics started to develop recently, thanks to the development of tools for matter wave manipulation. A crucial point for the success of quantum optics was the availability of twin-photon sources, based on a non-linear medium. Very recently, several approaches towards realizing twin-atom pairs have been investigated (most notably by the applicant and the host institution of this proposal) and successfully realized. The ETAB project will use this new twin atom beam (TAB) source to implement quantum atom optics experiments. Characterization of the resulting strongly correlated states will be performed through measurement of correlation functions. These experiments will go beyond the analogy with quantum optics due to fundamental differences between atoms and photons: mass and intrinsic nonlinearity due to interactions. This second property allows high efficiency twin atom beam generation, with an important pump depletion. This allows us to investigate new physics, including beyond linear response, quantum simulation, and non-equilibrium physics. Furthermore, by preparing the twin beams in an entangled state, we will perform the first test of Bell inequalities with untrapped atoms, which could rule out spontaneous decoherence  or gravitational nonlinearity  models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Re-thinking the fundamentals of vehicular networking with transportation theory and complex network science' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

ReFleX aims at characterizing in a comprehensive manner the topological features of large-scale urban vehicular networks built on top of DSRC-based V2V and V2I communication technologies. To that end, the project adopts a multidisciplinary approach, bringing together tools from vehicular networking, wireless communications, transportation theory, and complex network science.The study will unveil the (yet largely unknown) vehicular network connectivity properties induced by a pervasive adoption of DSRC technolgies in urban environments. That way, ReFleX will evidence the strengths, weaknesses and overall capabilities of large-scale V2V/V2I communication systems, including their actual availability and reliability.In turn, the understanding of the basic features of the vehicular network topology will allow testing current protocols and architectures intended for DSRC-based networks, by verifying their fitness to the connectivity dynamics of large-scale urban vehicular networks. ReFleX will then take an original bottom-up approach to protocol desgin that puts the network connectivity at the core of the process, and it will propose enhancements and novel network solutions that adapt to the actual features of the network topology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel Calix[4]arene Based Macrocyclic Heteroditopic Receptor Molecules for Ion-Pair Recognition and Interlocked Molecules Capable of Induced Molecular Motion' (IEFACP), addressing dissemination and exploitation.

assistant: **Impact**

Due to the potential uses that mechanically bonded molecules may have as molecular switches, sensors and machines, the interest being shown in discovering imaginative and high yielding templation methods for their construction and surface assembly is ever increasing. The use of rotaxane and catenane cavities as binding domains for the recognition and sensing of guest species because it remains underdeveloped which is surprising given their unique three-dimensional topological interlocked cavity design. In addition the host-guest binding and the molecular machine like behaviour of such mechanically bonded molecules will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High throughput development of drugs for immunotherapy of autoimmune diseases' (2002-2006).

assistant: **Innovation**

Rheumatoid arthritis, type I diabetes, coeliac disease and multiple sclerosis are common (auto) immune diseases that all have a well established HLA-association. This is likely the result of inappropriate T cell responses to peptides derived from (auto) antigens bound to the disease predisposing HLA-molecules. These diseases affect an estimated 6 million individuals in Europe alone and there are no established cures. Many of the key players involved in antigen presentation have now been identified.Simultaneously, combinatorial library approaches and novel developments in organic chemistry and molecular modelling now allow the rational synthesis of large numbers of related compounds that can be screened for biological activity in high throughput test-systems. The purpose of the current proposal is to bring together laboratories that have developed platform technologies with laboratories that study antigen presentation to develop effective inhibitors of antigen presentation. These include MHC/HLA-blocking compound s, T cell receptor blocking compounds, and enzyme inhibitors. We aim to achieve the design of inhibitors with computer-aided modelling.Next a dedicated synthesis protocol will be used to simultaneously synthesize the lead compounds and variants thereof. In the second approach dedicated (peptide) libraries will be designed and synthesized that are based on limited structural information concerning the target antigen or a potential lead compound. In both approaches the efficacy of the compounds synthesized will be tested in functional assays followed by optimisation of the most promising lead compounds.The project is highly dependent on the intensive collaboration between the laboratories that have the platform technologies operational and the other participants t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Vienna Biocenter European Researchers Night' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Science is central to the success of the European society and to tackle some of the major problems mankind is facing in the near future. Nevertheless, negative stereotypes about scientists persist. While a slow erosion of these stereotypes is detectable, continued and sustained efforts are necessary to overcome this prevalent barrier to increase the number of scientists in Europe. The most efficient way to tackle these stereotypes is known: bringing the general public into direct contact with science and scientists. This provides the inspiration for the researchers night initiative and the Vienna Biocenter (VBC) as a research cluster relying intensely on qualified personnel subscribes fully to this concept. Therefore the VBC-ERN proposes an attractive programme, which aims at bringing its research and scientists closer to more than 5.000 visitors from Vienna. The programme will explore links between science and art and focus on  hands-on experience of science  oral presentations of scientists explaining their work  exhibition resulting from various calls and activities  concert of bands from VBC-researchers Vienna is well known for arts and music and the Viennese are proud of this heritage. By exploring links between science and arts the VBC-ERN would like to provide evidence for the VBC being a lively and active part of modern Vienna and its cultural life. This should promote an increased understanding and acceptance for the activities of the VBC in Viennese citizens. By portraying research through art, the general public is invited to explore science from a stand-point of enjoyment and pleasure, which should lower the threshold frequently associated with science as too technical and complicated. Furthermore, by providing scientists with the opportunity to explore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The supercritical CO2 Heat Removal System' (2014-2020).

assistant: **Innovation**

Raising nuclear reactor safety to a higher level - The supercritical CO2 heat removal system - ""sCO2-HeRo""The “supercritical CO2 heat removal system”, sCO2-HeRo, safely, reliably and efficiently removes residual heat from nuclear fuel without the requirement of external power sources. This system therefore can be considered as an excellent backup cooling system for the reactor core or the spent fuel storage in the case of a station blackout and loss of ultimate heat sink. sCO2-HeRo is a very innovative reactor safety concept as it improves the safety of both currently operating and future BWRs and PWRs through a self-propellant, self-sustaining and self-launching, highly compact cooling system powered by an integrated Brayton-cycle using supercritical carbon dioxide. Since this system is powered by the decay heat itself, it provides new ways to deal with accidents that are beyond design. The sCO2-HeRo provides breakthrough options with scientific and practical maturity, which will be proven by means of numerical tools, like advanced CFD, and small-scale experiments to determine the performance of the components like a compact heat exchanger and a turbo-machine set. A demonstration unit of the sCO2-HeRo system will be installed in a unique glass model in order to demonstrate the maturity of the system. Finally, the potential of this system to deal with a range of different accident scenarios and beyond-design accidents will be shown with the help of the German nuclear code ATHLET.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AUTONOMOUS CLOUD-COMPUTING VINEYARD ROBOT TO OPTIMISE YIELD MANAGEMENT AND WINE QUALITY' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

VinBot responds to a need to boost the quality of European wines by implementing precision viticulture (PV) tools in the face of serious market threats worldwide and structural shortcomings within the EU wine sector. Wine producer associations have no control over yield management throughout their members’ vineyards, which leads to reduced quality wine at the association level. At the vineyard level, wine growers are not able to accurately assess yield due to the large amount of terrain to inspect, and use sample-based estimates of smaller production areas to estimate yield, which also negatively affects wine quality. An automatic yield monitoring system would allow winegrowers to accurately assess grape yield and relevant phyto-data via a set of sensors, tracking the state and location of the assets, generating maps, capturing sample locations, and sharing such information in a quick, flexible, autonomous and easy-to-use way. By means of a novel, all-terrain, autonomous robot, VinBot automates the traditional visual yield estimation process throughout the entire vineyard, estimating the amount of leaves and grapes on the vine via computer vision and other sensors. Data-intensive computer vision algorithms are offloaded to external internet servers (the cloud). The VinBot extends visual leaf and fruit estimation throughout the entire vineyard, and centralises yield management in the SME-AGs by providing them with online yield maps of their members' vineyards. The VinBot represents a powerful precision viticulture tool, which does not exist today: the cloud-computing agricultural robot. Using the VinBot, the consortium SME wine producer associations will be able to coordinate and optimise yield management strategies throughout their thousands of members' vineyards, based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Graphene for Semiconductor Industry'.

assistant: **Objectives**

G4SEMI goal is to create added value through the introduction of high performing Graphene-on-wafer at competitive cost,accelerating innovation for the advanced semiconductor industry and eventually creating a new product category. This newarea of development will make it possible for the European industry to harness this market high potential, fosteringcompetitiveness and creating growth throughout the EU. GS proposes this Phase 2 project after the updated Phase 1Business Innovation Plan, in order to take the CVD Graphene-on-wafer technology a step closer to the market through 3specific applications: photosensors, biosensors and memory devices. This project will allow GS to become the worldwide leaderas Graphene-on-wafer producer with the necessary production capacity to supply the semiconductor industry and theresearch laboratories.More specifically, the G4SEMI objectives are:• To develop ready-to-integrate Graphene-on-wafers for the semiconductor industry (memory devices, photosensors orbiosensors).• To produce custom made Graphene-on-wafer for each of the 3 different applications.• Increase process yield and implement an automated and optimised quality control.• To supply 200mm wafers (industry standard) to the semiconductor market.• Scale production capacity to more than 10,000 wafers/year to demonstrate commercial viability• Reduce more than 10 times the Graphene-on-wafer cost per cm2 (by scaling up and improving quality control).GS has validated and patented a highly efficient Graphene-on-wafer production process and its application into electronicdevices.GS will be able to introduce Graphene-on-wafer materials at industrial scale positively impacting the €545 billionsemiconductor devices market. GS will become the worldwide leader in Graphene-on-wafer for semicon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'VIRGO: Studying a VIRal Gpcr in Oncogenesis' (VirGO), addressing dissemination and exploitation.

assistant: **Impact**

The Epstein–Barr virus (EBV) is widespread in all human communities. While most people carry EBV as a life-long asymptomatic infection, in some people, EBV contributes to malignant transformation and is responsible for ~200,000 new cancer cases/year. Small molecule inhibitors targeting viral proteins could be an effective option to treat people with EBV-associated cancers. However, no such drugs exists which in part reflects the limited repertoire of targetable virus proteins present in EBV-driven cancers. Recently, the Experienced Researcher (ER) has shown that the tumour cells of EBV-associated cancers such as Burkitt lymphoma (BL), express the EBV-encoded BILF1, a constitutively active G-protein coupled receptor (GPCR). Furthermore, preliminary data by the ER indicate that BILF1 partially recapitulates the aberrant transcriptional programme of BL and is likely to do so through activation of oncogenic cell signalling pathways that include AKT-mTOR. These data suggest that BILF1 could be a realistic therapeutic target, raising the possibility of advancing the development of anti-viral drugs to treat EBV-related tumours; GPCRs are the most successful class of drug target for the treatment of human disorders and are emerging as anti-cancer targets. In this project the ER will harness new models of B cell lymphomagenesis available in the host laboratory to: 1) Explore the role of BILF1in the transformation of germinal centre B cells; the progenitors of BL; 2) Identify how BILF1 contributes to the established phenotype of BL cells; and 3) Link these phenotypes to pathological features of the primary tumour and to patient response to therapy. Thus, the Fellowship will significantly advance knowledge of the mechanisms of EBV-mediated oncogenesis, in turn paving the way for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regenerative medicine for cost- and time-efficient pet treatment' in the context of a Horizon 2020 call.

assistant: **Objectives**

There are a number of different veterinary diseases for which current medicine (surgical techniques and drugs) offer absolutely no solution like osteoarthritis and neurological, autoimmune and inflammatory diseases. Today, the treatment of these disorders could get benefit from the administration of stem cells. At Vetherapy we provide stem cell therapies and regenerative products for veterinary application, in an easy, ready-to-use, and affordable manner. We have used our knowledge and experience to develop a whole set of products that use stem cells and stem cell’s derivatives to a variety of scenarios, from injury to degenerative disorders. The secret of our success is based on an innovative technology that allowed us to overcome one of the major difficulties of the application of stem cells: cell viability. Our technology extends cell viability up to 48h (vs. 4-6h of current methods) and enables the delivery of a ready-to-use high quality product, anywhere within this time frame.Following very promising pre-clinical results where we tested the safety and efficacy of our product, we now plan to commercialize our inventions PET-STEM and WOUND FIX® by optimizing their design and carrying out a large veterinary clinical trial.The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of PET-STEM and WOUND FIX® and their market uptake.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Involvement of EXtracellular vesicles in cell wall remodelling and InTercellular communication during the apical growth of PLANt cells.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In today’s fast-paced world, the need for innovative solutions leads to a preference for applied sciences over fundamental research, to the detriment of possible ground-breaking discoveries and revolutions in the future. This is the case of plant extracellular nanovesicles (PEVs), small vesicles secreted by plants which were first discovered in plant defence against pathogens, but that were soon co-opted by the biomedical research as promising nutraceuticals and drug delivery tools. To date, the majority of scientific literature on PEVs focuses on their possible therapeutic uses. Nonetheless, little is known about their biogenesis, secretion mechanism, and function in the plant kingdom, especially in physiological processes such as cell growth. This enormous gap in knowledge not only hinders their exploitation in plant biotechnology and agronomy, but also limits their safety in medical applications. EXIT PLAN will fill in this gap addressing three main research objectives (ROs), through three research work packages (WPs). First, the project will assess the nature of PEVs secreted during the apical growth of plant cells (RO1, WP2), and in particular pollen and root hairs. For this purpose, biomedical techniques for the characterisation of human nanovesicles will be readapted to isolate and characterise PEVs, during the secondment at Nottingham Trent University. Then, RO1 will be furtherly investigated at the University of Zurich, using plant transformation, advanced microscopy, and omics analyses to identify different PEVs populations. The same approach will be adopted to unveil how PEVs are externalised from the cell wall (RO2, WP3). Finally, the techniques learned during the outgoing phase will be implemented with a molecular biology approach at the University of Bolog