RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Memory Enhancing and Learning System' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Advances in neuroscience have returned the focus on learning, placing the relationship between sleep and consolidation of memory at the centre of academic debate. There are two types of sleep: rapid eye movements and slow wave sleep (SWS). Although both types of sleep have been related to memory consolidation, accumulated evidence points more to the relationship between SWS and memory (L. Marshall, et al., ""Boosting slow oscillations during sleep potentiates memory"", Nature, vol 444, No. 7119, pp. 610-613, Nov. 2006). In addition, it has recently been shown that the SWS promotes the formation of new synapses after learning (G. Yang, C. S. W. Lai, J. Cichon, L. Ma, W. Li, and W. B. Gan, ""Sleep promotion branchspecific formation of dendritic spines after learning"", Science, vol.344, no. 6188, pp. 1173-1178, 2014).The general objective of MemBoost is the modulation of sleep for the significant improvement of memory and learning process. The Hardware is a low cost wearable device, innocuous and very easy to use, which consists of a module for recording and processing the electrical signal (EEG) in real time that, by means of a software in a mobile device, is able to distinguish between different states of wakefulness and sleep and produce a non-invasive (audible) stimulus to be delivered to the user and thus produce sleep modulation. Sleep modulation is achieved by synchronized stimulation in phase with the brain's electrical activity. In this sense, modulation is understood as the process of modifying one of the qualities of sleep, in this specific case the duration and quality of slow wave sleep, SWS, are modified. Unlike other applications available on the market, MemBoost is based on solid and recent scientific and academic research that demonstrates improvements in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New Light on Chemical Dynamics' under Seventh Framework.

assistant: **Concept**

New theory and computational methods are crucial to unlock the full potential of new ultrafast experiment soon to be made possible by light sources currently under construction, such as the European XFEL in Hamburg and the LCLS in Stanford. This proposal focuses on ultrafast diffraction imaging, either by x-rays or electrons, and a new intense-laser technique, high harmonic spectroscopy. The distinct advantage of diffraction based techniques is that they allow a direct interpretation of molecular dynamics in terms of the motion of atoms, while the high harmonic spectroscopy is spectacularly sensitive to the electronic changes that accompany chemical transformations and which often govern the outcome of photochemical reactions. In short, these two sets of techniques have the potential to revolutionize our ability to observe and control photochemistry and ultrafast dynamics, but the theoretical tools to interpret them are missing. I will develop these tools and significantly advance the state-of-the-art in quantum simulations by making realistic start-to-finish simulations of the experiments possible. This can only be achieved by adapting cutting-edge techniques from atomic, molecular and optical physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PREPARATORY PHASE FOR THE PAN-EUROPEAN RESEARCH INFRASTRUCTURE DANUBIUS–RI “THE INTERNATIONAL CENTRE FOR ADVANCED STUDIES ON RIVER-SEA SYSTEMS'.

assistant: **Innovation**

DANUBIUS-PP is a three-year project to raise DANUBIUS-RI (International Centre for Advanced Studies on River-Sea Systems) to the legal, financial and technical maturity required for successful implementation and development. DANUBIUS-RI is a pan-European distributed research infrastructure (RI) building on existing expertise to support interdisciplinary research on river-sea (RS) systems, spanning the environmental, social and economic sciences. It will provide access to a range of RS systems, facilities and expertise, a ‘one-stop shop’ for knowledge exchange, access to harmonised data, and a platform for interdisciplinary research, education and training.DANUBIUS-PP will bring together key stakeholders at different levels, and strengthen the consortium through a process of wide engagement. Individual work packages will refine, inter alia, the scientific and innovation agenda, the legal framework, governance and management, and policies for access and data management. The financial requirements of the RI will be refined to assist funding agencies as they consider future spending priorities.Key deliverables of DANUBIUS-PP include development of the legal and financial agreements for the components of the RI (including Hub, Nodes and Supersites), their governance, and internal organisation which will be confirmed via a Memorandum of Understanding. This preparatory phase project will develop the structures and processes to ensure that the RI strengthens scientific performance by providing a sustainable basis for future operation, delivering key services to the different user communities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Architectured Soft Magnetoactive Materials: Beyond Instabilities'.

assistant: **Concept**

Soft magnetoactive materials can change their properties and undergo extremely large deformations when excited by magnetic stimuli. These reconfigurable soft materials hold great potential for a large variety of applications from sensing devices to energy harvesting, noise and vibration mitigation, and soft robotics. However, these materials operate at high magnetic fields, thus, limiting potential application of the technology. A promising approach to significantly enhance the magnetomechanical performance, and reduce the required magnetic field, is to design soft magnetoactive composites through architectured microstructures. Highly ordered microstructures are an origin for multiscale magnetomechanical instabilities and possible failure of the materials. In this research proposal, we directly address this crucial aspect for MAE-based technology. Moreover, we declare an ambitious goal: Turning failure into functionalities.Our strategy is to take the risk of operating MAEs in the unstable regime with predesigned instability developments. This novel MAE design concept will capitalize on controllable cascade microstructure transformations while attempting to avoid catastrophic failure. If successful, this concept will open a new avenue in design of morphing magnetoactive materials with new functionalities and superior performance. To achieve this ambitious goal, we will develop multiscale theoretical and computational frameworks to reveal and to predict the behavior of possible advantageous microstructures in the extreme regimes. If successful, we will fill the gap in magnetomechanical multiscale instability phenomena, and will significantly advance the frontier of knowledge about the reconfigurable soft matter. We will probe our ideas experimentally, and will fabricate t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Commercial feasibility of targeting the histone methyltransferase SETD8 in cancer: New chemical entities and biomarkers.' under Horizon 2020.

assistant: **Concept**

Within our ERC CoG grant, RSHEALTH, our group has contributed to the to the preclinical development of chemical inhibitors of the ATR kinase as anticancer agents, that are now in clinical trials by several companies. During the course of our investigations, we also made important advances in developing inhibitors of SETD8, another interesting cancer-related target. SETD8 is a histone methyltransferase known to play important roles in DNA replication and repair. Evidence indicating that targeting SETD8 could be interesting for cancer therapy has been building up in recent years. For instance, SETD8 is overexpressed in a wide range of cancers, and recent works identified SETD8 as a specific vulnerability in High-Risk Neuroblastoma or MYC-driven Medulloblastomas. Unfortunately, all available SETD8 inhibitors have low potency and poor pharmacological properties, and none has progressed to the clinic. We here propose to capitalize in our strengths in academic drug development, and our experience in transferring our inhibitors to the industry, in order to facilitate the clinical development SETD8 inhibitors. Our proposal includes objectives that will help us improve the quality of our inhibitors, valorise them in preclinical cancer models and develop companion biomarkers that would be used for patient stratification. All of this would be integrated within a business plan that should facilitate a coherent development of this line of work oriented towards the clinical development of SETD8 inhibitors for the benefit of cancer patients.


**Keywords:** SETD8,  Cancer,  Drug Development,  Pharmacology,  Biomarker,  Preclinical valorisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Topological solitons in ferroics for unconventional computing'.

assistant: **Innovation**

TOPOCOM is a network of leading European groups from different disciplines and sectors selected to provide comprehensive training on the integrative concepts underlying the science of topological solitons in ferroic materials and their application in unconventional computing. Topological solitons are a rich source of emergent physical phenomena and most promising nanoscale systems for future technology, enabling conceptually new pathways for low-energy information processing and sensing, as well as integrated data storage. Many of the developments in the field have occurred only in the past few years and it is clear that we have only scratched the tip of the iceberg concerning the topological solitons that form in electrically or magnetically ordered materials. To realize their potential, the consortium comprises the best groups in materials synthesis and modelling to stabilize such solitons, modelling and studying their dynamical responses to external stimuli, and designing and fabricating devices, where solitons carry out ultralow-power computing and sensing functions. While clearly a challenging topic, there are major benefits that result from a unified treatment of electric and magnetic solitons as realized in this TOPOCOM. The network spans the whole range from fundamental physics and applied materials science - linking both experimental and theoretical aspects - to industrial-scale production and evaluation. The scientific part (“Training through Research”) is complemented by advanced transferable business and cultural skills training (“Training for Life”), providing Europe with a unique training programme at the forefront in unconventional computing based on electric and magnetic solitons. TOPOCOM will establish innovative solutions for more sustainable informati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Signalling in life cycle stages of malaria parasites' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Malaria is a major public health problem in the developing world and is endemic in many regions of India.  The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites.  Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites.  The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely:  (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators)  in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites.   Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium.  Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites:  • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters)  Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites.  The project will significantly strenghten EU-India cooperation in this highly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PROTEASES VISUALIZATION DURING TUMOR PROGRESSION'.

assistant: **Innovation**

Cancer is one of the most devastating diseases leading to millions of deaths per year, and cancer research is a major topic in many laboratories in academia and industry. The main goal in this proposal is to understand the biology of cancer progression that will lead to the discovery of new, more tailored and personalized anticancer therapies. One of the largest group of enzymes that greatly contribute in cancer progression are proteases. In this project I will leverage the production of highly selective chemical probes to investigate the contribution of medically important proteases in tumor progression in PDX (Patient-Derived Xenograft) mice models using a new analytical technique  - mass cytometry. This goal will be achieved via a four-step approach employing techniques from organic chemistry, analytical chemistry, biochemistry and biology making this project multidisciplinary. Proteases that have been chosen for this purpose are caspases, legumain and cathepsins B, L and S for which I will synthesize very specific, small molecule radiolabeled inhibitors suitable for mass cytometry approach. These probes will be first evaluated on recombinant enzymes and simple cell systems and then they will be applied to PDX mice studies. PDX models offer an excellent possibility to study human cancer biology in system most closely related to in vivo pathology. So far there are no reports in the literature regarding the use of mass cytometry in studies of PDX mice models, which makes this project very unique and innovative. This PROVIST project will be performed in Sanford Burnham Medical Research Institute, USA (24-months outgoing phase, prof. Guy Salvesen Lab) and at Wroclaw University of Technology, Poland (12-months return phase, dr. Marcin Drag Lab). The research and training
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Transnational Orthodoxy in Wartime: Ecclesiastical Geopolitics and Identity in Ukraine, Moldova, and Estonia'.

assistant: **Objectives**

In the wake of Russia’s 2022 invasion of Ukraine, Orthodox Christianity has reemerged as a crucial site where struggles over sovereignty, national identity, and geopolitical alignment play out. Transnational Orthodoxy in Wartime (TRANSORTH) examines how rival Orthodox churches in Ukraine, Moldova, and Estonia, as part of broader transnational Orthodox networks, respond to the war, articulate competing visions of nationhood, and both shape and are shaped by domestic and international politics. Despite recent scholarly focus on Ukrainian Orthodoxy, post-2022 dynamics in Moldova and Estonia remain largely unexplored, and existing studies often lack sustained theoretical engagement. Integrating interdisciplinary perspectives from religious studies, international relations, postcolonial theory, and security studies, TRANSORTH develops a novel analytical framework combining discourse analysis and critical policy analysis. The project will build open-access databases of church and state documents, analyse key texts and policies, and produce peer-reviewed publications and policy outputs. Hosted at the University of Copenhagen under the mentorship of leading experts, it includes short research visits to Estonia, Moldova, and Germany to strengthen regional insights and networks. TRANSORTH will generate new insights into transnational religion in conflict, inform EU policy on resilience and security, and enhance the researcher’s academic independence through advanced training in digital methods, grant writing, and public engagement. The project directly supports the EU’s strategic agenda to strengthen democratic resilience and counter hybrid threats, both within the Union and in its Eastern Neighbourhood.


**Keywords:** Orthodox Christianity, national identity, geopolitical imagi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Archaeological Coastal Heritage: Past, present and future of a hidden prehistoric legacy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

DN ArCHe trains 10 PhD fellows for increasing the scientific and public value of Europe’s archaeological coastal heritage, focusing on the legacy of Stone Age hunter-fisher-gatherers. Including some of the earliest remains of human activity, this legacy is crucial for understanding human engagement with the coast. Yet it is fragile and highly heterogeneous, with diverse material and cultural expressions. It is embedded in a variety of geographic settings across Europe differing in environmental development, which face massive environmental and human threats. It is also approached in various ways in cultural heritage management with little systematic integration of knowledge on the topic. DN ArCHe deals with the challenges of this fractured field with an innovative past-present-future approach which focuses on connecting the legacy from the past, its present status as archaeological heritage and prospects for its future protection and integration. With six beneficiaries and nine associated partners, ArCHe unites academic research centres and non-academic organizations (cultural heritage sector, specialist organisations, museums, media). As a joint platform for research and training, it leverages on customized PhD projects, cross-fertilization of knowledge among researchers and partners, scientific courses, workshops, conferences, applied secondments and transferable skills training. Training in archaeology, anthropology, critical heritage studies, heritage management, bioarchaeology, geology, oceanography, coastal engineering/preservation and communication relevant to coastal heritage and environment, equips ArCHe PhDs with advanced interdisciplinary and cross-regional knowledge and skills applicable to various academic and non-academic fields across Europe. Through best