RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Menstrual migraine: understanding its pathophysiology and developing precision treatment strategies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Females experience 3 times more migraine attacks than males, with menstrual migraine affecting 60% of these females. They occur before or during menses and are associated with oestrogen (E2) withdrawal, dramatically affecting a patients quality of life. Menstrual migraines are poorly understood, limiting novel treatment strategy discovery. Recently, I demonstrated that E2 withdrawal increases the function and forward membrane trafficking of specific potassium channels (Kv7) in systemic arteries. If present within the cerebrovascular system, E2 withdrawal will increase sensitivity to endogenous migraine-inducing vasodilators, such as calcitonin gene-related peptide (CGRP), contributing to migraine onset.This project is split into two objectives. 1.) Investigate oestrus cycle-dependent changes in rodent cerebrovascular reactivity via molecular, functional and electrophysiological techniques, with a focus on E2 mediated changes in Kv7 subcellular trafficking via novel G-protein coupled oestrogen receptor, GPER1. 2.) Translate pre-clinical basic science research generated in objective 1 into a model of mensural migraine. International collaboration with Prof. Geoffrey Abbott at the University of California, Irvine, allows for access to in vivo Hemodynamic Perturbation Monitoring (HPM) and a novel CRISPR/Cas9 Kv7 knockout rat. HPM allows for simultaneous measurement of cerebral blood flow and migraine onset (induced by CGRP). We will investigating if female rats are more susceptible to migraine induction when E2 is low, and and whether they are protected from migraine induction by GPER1 stimulation or Kv7 knockout.Our project has the potential to reveal novel pathophysiological mechanisms underlying menstrual migraine allowing the development of novel precision treatment str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EVOLUTION OF CYANIDE METABOLIMS IN APOSEMATIC BUTTERFLIES: from gene characterization to community ecology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The colourful and toxic Heliconius butterflies are well-established models to study evolution of aposematims and mimicry, yet the genetic basis of their toxicity and how this varies in different populations remains unknown. Heliconius are toxic butterflies because they contain cyanide-releasing compounds called cyanogenic glucosides, which they can both biosynthesize or uptake from Passiflora plants, their co-evolutionary partner, during larval feeding. This multidisciplinary project brings together ecology, genetics, biochemistry and evolutionary biology to investigate how toxicity and interactions with Passiflora plants has shaped the evolution of these butterflies. Thus, I will combine the gene-editing technology CRISPR-Cas with different OMICs approaches (metabolomics, transcriptomics and phenomics) to (1) decipher the genetic and phenotipic bases of cyanogenesis in Heliconius butterflies and (2) unravel the evolutionary trajectory of this defence system in the Heliconiine tribe. Moreover, I will also (3) establish how cyanogenesis vary  within and between tropical and subtropical heliconiine-Passiflora communities of the Brazilian Atlantic Forest, a biodiversity hotspot endangered by extreme deforestation.This project will give me the unique opportunity to expand my knowledge and skills repertoire on genetics, ecology, evolutionary biology and bioinformatics. I will be trained in advanced techniques such CRISPR-Cas, gene expression analysis, R programing, statistical methods applied to community ecology and matabolomics, etc. Also, during this fellowship I will excel my teaching/supervision, project management and communication abilities. All these expertise will be extremely valuable for the execution of the project and will bring great progress to my career devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Carbon dioxide capture and sequestration in geological storage technology network development programme, 2000-2001' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Extensive external interest in two EU projects on CO2 sequestration into geological storage; SACS, an industrial scale demonstration into a saline aquifer and GESTCO, assessing the potential for geological storage in Europe, demanded immediate action, resulting in the development of this technology development awareness and networking proposal, CO2NET, to promote and facilitate the diffusion, transfer, exploitation and broader use of the projects' results to help meet Kyoto emissions reduction demands.CO2NET is in addition to any existing work, so is being developed by an independent project manager under the auspices of the IEA Greenhouse Gas Programme. CO2NET will provide workshops, conference papers, publications and website for dissemination. Phase 1 to mid 2001 will be assessed on its success and continuation through 2002.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative DePaLletiser for the automated feeding of signatures in the  bookbinding industry' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The printing sector is a mature market with annual revenues of €694 billion worldwide and a relevant presence in Asia, Europe and USA which, however, needs to increase its competitiveness by reducing costs and improving margins. The book printing industry presents a key problem for the hardcover bookbinding, as part of the post-impression process (depalletisation of stacks of signatures to feed the bookbinding machine) has to be done manually. D-PAL is a high-performance & 100% automated depalletiser for the hardcover book post-printing process which accurately depalletises stacks of signatures of different types, sizes and thicknesses (65-215 mm.) for the automatic feeding of the bookbinding machine. D-PAL is the only machine in the market suitable to be integrated in every process chain with the current methods existing in the book printing industry.D-PAL will save 6,9% of the total printing costs for hardcover books and will increase the depalletising yield up to 367%, avoiding at the same time quality defects associated to manual works. Costs derived from H&S accidents will be reduced up to 30%.  Moreover, the depalletising time will be reduced up to 68% and the machine can be amortized in 1,2 years. D-PAL is 41% less expensive than competitive solutions. D-PAL has been developed by LARGOIKO S.L.L, a Spanish Mechatronics Engineering enterprise that designs and carries out the automatization of industrial processes, special machines or under demand since 1999 in different sectors such as automotive, electronic devices, renewable energies or graphic arts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monitoring risk factors of spreading of leishmaniasis around the Mediterranean basin' in the context of a Sixth Framework call.

assistant: **Objectives**

Visceral and cutaneous leishmaniases are serious communicable diseases around the entire Mediterranean basin, including Southern Europe. These diseases are spreading and control is challenged by three escalating risk factors: human-made environmental chang es, immunosuppression (essentially because of Leishmania/HIV co-infection) and parasite resistance to first line drugs, pentavalent antimonials. Trans-border multidisciplinary surveillance of these three risk factors is essential for (i) precise and integr ated assessment of the risks, (ii) defining adequate control measures and (iii) the orientation of R&D priorities. Our general objective is to create a multidisciplinary network linking European and South/East Mediterranean partners in order to documen t the main risk factors involved in the spread of leishmaniasis around the Mediterranean and to promote transborder control strategies Our specific objectives are: 1.to review, assess and inform on current scientific knowledge on the epidemiology and cont rol of leishmaniasis around the Mediterranean; 2.to co-ordinate existing research on surveillance and control of leishmaniasis; 3.to disseminate and standardise relevant tools and good practice arising from research; 4.to advise national, regional and in ternational health authorities about the most effective transborder control measures; 5.to identify the gaps in current knowledge and expertise, and to define future multidisciplinary research to remedy the situation through co-ordinated action. Expected deliverables are: (i) 6 workshops for the 22 Euro-Mediterranean consortium partners, (ii) 3 short training courses (molecular epidemiology,diagnosis, GIS), (iii) constitution of a multidisciplinary expert group, (iv) reviews, opinion papers and guideline s and (v) 1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Séparation des pouvoirs entre politique et juridictionnel en droit de l'u.e.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

L 'objectif du présent projet est de définir et de conceptualiser la question de la séparation des pouvoirs dans le cadre du système institutionnel de l'Union européenne. Plus précisément, il s'agit d'établir quelles sont les articulations entre les institutions politiques de l'Union et ses institutions juridictionnelles, puis de déterminer le sens et la portée de la théorie de la séparation des pouvoirs dans cette configuration institutionnelle. Le cadre méthodologique adopté sera celui du droit constitutionnel, et dans une moindre mesure du droit comparé. Le projet implique un travail préliminaire sur la théorie de la séparation des pouvoirs dans une perspective comparée, notamment dans les systèmes constitutionnels des Etats occidentaux avec une attention particulière portée aux systèmes fédéraux. Puis, il conviendra d'établir les frontières du partage des pouvoirs entre le politique et le juridictionnel. Ces frontières résultent des traités constitutifs, des pratiques institutionnelles et, surtout, de la jurisprudence de la Cour de justice, portant sur ses propres compétences ainsi que sur les limites du pouvoir discrétionnaire des institutions politiques. L'accent sera mis sur l'évolution récente de la position de la Cour à ce sujet, ce qui n' a pas fait l'objet de développements importants dans la doctrine. Cette analyse débouchera sur une tentative conceptualisation de l'objet ainsi défini.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Topics in Behavioral-Economics Theory' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

This proposal outlines projects that span a diverse set of specific topics in both the foundational and the moreapplied parts of behavioral-economics theory.In the foundational projects, I will develop broadly applicable models of individual decisionmaking thatincorporate psychologically realistic assumptions about individuals, and that can be used by myself andothers to study the implications of psychological phenomena for economic outcomes. I will (i) provide anattention-based theory of several central and hitherto unmodeled aspects of mental accounting; (ii) analyzethe implications of overconfidence about one’s ability or prospects for learning about other economicallyimportant variables; and (iii) incorporate into economic settings, and explore some consequences of, theidea that self-esteem— our feelings about ourselves—may be exceedingly fragile.In the more applied projects, I will use psychologically realistic models to shed light on important economicissues regarding markets and organizations. I will (i) identify market outcomes and especially welfareincreasingregulations when consumers with limited attention make tradeoffs between “browsing” moreproducts superficially and “studying” fewer products in detail; (ii) use a contract-theoretic approach to helpunderstand and possibly undermine organizations that pursue goals its members oppose; (iii) analyze the natureand consequences of procrastination when a person’s alternative choices are supplied by the market; (iv)explore the potential for a policy framework centered around informed consent to address privacy concernsin a market where some consumers are naive about product offers; and (v) investigate the implications offinancial choice and financial information in a market for retail securities when investors do
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Real and synthetic scenarios generated for the development, training, virtual testing and validation of CCAM systems' under Horizon Europe.

assistant: **Concept**

SYNERGIES confronts pivotal challenges within the CCAM community, such as the absence of interoperable scenario databases, time-consuming and expensive development cycles, and regulatory ambiguities. It achieves this by implementing the Safety Assurance Framework developed in HEADSTART and SUNRISE. SYNERGIES furnishes stakeholders with interoperable, federated scenario databases, incorporating data from Safety Pool Scenario Database™, ADScene, StreetWise, VV Methods, L3Pilot, Hi-Drive, and more. This facilitates standardized processes, streamlines development cycles, and ensures regulatory compliance.To accomplish this, SYNERGIES will culminate in a European platform designed to enhance the development, training, virtual testing, and validation of CCAM systems. The SYNERGIES Platform comprises a Scenario Dataspace, aligned with Europe's approach to data sharing and competitiveness, and a Marketplace, ensuring continual updates and Dataspace scalability.Furthermore, SYNERGIES encourages the inclusion of new initiatives into the scenario dataspace by offering the requisite tools and guidance, from data processing and scenario identification to scenario database governance. This presents a unique opportunity to amplify investments in research and development, consolidating Europe's leadership in CCAM development, all while prioritizing safety and data protection.


**Keywords:** scenarios, database, marketplace, dataspace, CCAM, validation, safety
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The future of mathematics and science: Knowledge relationships and equitable participation'.

assistant: **Innovation**

This research concerns the low and inequitable participation of young people in mathematics and science. Relationships students form with knowledge are critical to their engagement and their decisions to continue with subjects. Four domains within knowledge relationships have so far been identified: the agency students believe they have as they work (the opportunities they perceive to ask questions, use their own ideas, connect different ideas and explore); the authority they turn to as they work; their interest in the subjects; and their beliefs about the nature of the subjects.This research will further investigate knowledge relationships, and the ways that they impact on student choices and their identities as learners, with a particular focus on gender equity. The research will identify schools that are particularly successful and less successful in encouraging students in general, young women in particular, to take mathematics and science. Extensive observations and interviews will identify conditions under which productive participation is encouraged, and explore the knowledge relationships that students form in different circumstances. In subsequent years young people will be tracked into their universities to monitor their experiences and decisions in university mathematics and science departments.These two studies will be framed by a third study of the ways that mathematics and science are portrayed in the media and other public representations, and the impact of such images on young people's choices. Wide and effective dissemination will result in recommendations for changes that could have a significant impact on the numbers of young people choosing to study mathematics and science in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Photoredox Catalysis for Sustainable Organic Synthesis'.

assistant: **Concept**

The aim of this proposal is to develop new and sustainable synthetic methods employing visible light as the sole energy source. MacMillan has demonstrated this concept by merging photoredox catalysis with organocatalytic protocols to perform previously unknown direct enantioselective carbonyl α-functionalization reactions. Building upon this precedent the outgoing phase of this project seeks to incorporate this photoredox process into an organocascade catalysis sequence to generate synthetically valuable intermediates that are relevant in medicinal and natural product chemistry. In this project we propose the merger of iminium ion catalysis with a photoredox-organocatalytic process to generate enantioenriched aldehydes that are α- and β-functionalized from inexpensive and readily available starting materials. This would constitute the first example of an organocascade sequence involving a photoredox system and its compatibility with iminium ion catalysis.During the return phase photoredox catalysis will be merged with gold chemistry to develop a new methodology for the construction of biaryl systems, which are ubiquitous in pharmaceuticals and organic materials. This protocol will provide a complementary procedure to the Au-catalyzed arylation reaction disclosed by the Lloyd-Jones group, which utilizes arylsilanes as coupling partners. This approach presents a more sustainable approach to biaryl formation that generates less chemical waste and involves readily available starting materials. Overall, the pioneering nature of this proposal as well as the opportunity to forge new international collaborations between two leading research institutions would contribute significantly to scientific excellence in Europe. Moreover, the fellow would develop and gain numerous skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Light-controlled nanomagnetic computation schemes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Computation using nanomagnets could serve as a low-power alternative to existing CMOS technologies. Here, binary information is encoded into two stable magnetic configurations of single-domain nanomagnets. In the last ten years, significant progress has been made towards the implementation of nanomagnetic networks for computation, either in the form of Boolean logic gates, or for more complex optimisation tasks. However, operational reliability and on-the-fly tuneability have remained problematic.Here, we propose to use surface-plasmon-induced local heating schemes to enable local, selective, and fast optical control of the relaxation pathways of nanomagnetic arrays. This novel approach towards the active manipulation of thermal magnetic relaxation potentially allows for the implementation of low-power, ultra-fast advanced computation schemes, such as reservoir computing.