RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Cosmology of dynamically evolved structures, from protogalaxies to galaxy clusters - theory developments, comparisons to simulations and observations'.

assistant: **Objectives**

Research objectives and content Much effort is being devoted to understanding the problem of gravitational dynamics. Computer simulations provide solutions, but are much time-expensive. Analytical arguments, tested against simulations, can provide fast and cheap predictions on dynamically evolved structures, to be compared to cosmological observations which are being performed. The objectives of this research are: to develop an analytical framework, based on realistic approximations to gravitational dynamics, such to readily provide predictions on large cosmological collapsed structures, such as protogalaxies or galaxy groups and clusters. To test this analytical framework against numerical simulations. To compare the predictions of various cosmological models to new observations. The analytical framework will be mainly based on a Lagrangian fluidodynamical formulation. It will provide predictions on the mass distribution, merging histories, angular momentum, real-space and redshift-space positions of collapsed structures, their influence on the CMBR. After testing against computer simulations, these predictions will be compared to observational data on protogalaxies and galaxy systems. This will provide valuable constraints on cosmological parameters. Training content (objective, benefit and expected impact) The applicant expects to further specialize and widen his knowledge in cosmology, from theory to simulations and observations, produce valuable research, and take benefit from an exceptionally stimulating environment. Links with industry / industrial relevance (22) Indirect, through the host institution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preparation and certification of reference materials for the determination of the mycotoxin zearalenone' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The contamination of maize by fungi, especially by Fusarium species is a world-wide problem. One of the most prevalent Fusarium mycotoxins frequently found on European maize is zearalenone (ZON). ZON has been implicated in a range of human and animal diseases. It shows remarkable oestrogenic properties and can cause severe reproductive and infertility problems in farm animals, particularly in pigs. Moreover, exposure to ZON may cause the development of cancers, genetic mutations and birth defects. Therefore, the contamination of maize with ZON is a threat to animal and public health and seriously reduces the quality of maize products. A summary of the surveys on the natural occurrence of ZON in the EU showed that ZON occurs in almost every agricultural product at concentrations ranging from 1 to 2000 ùg/kg. The very high export and import volume of maize within the EU in 1996 of about 1 billion ECU proves the economical relevance of contaminations with ZON. This underlines that accurate determination of ZON in maize is necessary either for health protection of consumers and for the industry to guarantee the quality assurance of the products and to avoid trade barriers. Though ZON is one of the five most frequently determined mycotoxins there is a lack of reliable and validated methods. In addition, there is no certified reference material (CRM) available for ZON analysis, which would enable the comparability of measurement results between European laboratories. Therefore, in their latest resolution, the European Committee for Standardisation (CEN/WG5) underlined the necessity for a CRM for ZON in maize. These findings have led to the proposed project, with the aim to improve the quality of analysis for ZON at a European level and to develop CRMs for ZON in maize. The pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Analysis of the interplay between genetic mutation and altered cellular metabolism in renal neoplasia'.

assistant: **Objectives**

Defining and characterising the defective genes in hereditary cancer syndromes has advanced our understanding of cellular function and disease mechanisms. Interestingly, some of these genes have been directly implicated in metabolic dysregulation, thus providing a link between genetic mutation and altered metabolism in cancer. One such syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), is caused by germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase. The aim of this proposal is to define pathways disrupted in HLRCC and within these to determine specific points, susceptible to genetic or chemical intervention, from which therapies might be derived to treat or prevent tumourigenesis. First, we will assess candidate mechanisms for FH-associated tumourigenesis which we have identified through recent studies, encompassing enzyme inhibition, protein modification, anti-oxidant signalling and altered energy metabolism. Secondly, to identify novel RCC associated mutations and clarify their relevance in the evolution and metabolism of RCC, transposon-based mutagenesis will be employed to induce RCCs in both wildtype and Fh1-deficient mice. Analyses will include histological analysis, metabolite profiling, and high resolution sequencing. Candidate genes will then be screened in relevant human RCC and pre-malignant lesions. Finally, a synthetic lethality screen will be performed in parallel with metabolic profiling to identify the pathways that are critical for the growth of FH-null cells. Taken together it is envisaged that this work will not only provide insights into this rare but aggressive disease but also inform on potential targets for intervention in more common cancers that are also characterised by metabolic dysregulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fast optoacoustic mesoscopy, using the skin as a window for therapeutic monitoring of local and systemic disease.' under Horizon 2020.

assistant: **Concept**

Optoacoustic (photoacoustic) imaging dramatically improves upon conventional bio-optic barriers and enables three-dimensional, high-resolution optical imaging deep inside tissues (several mm to cm). Clinical optoacoustic macroscopy has been supported by two ERC Advanced Awards (2008, 2016; Prof. Ntziachristos). In parallel, under the ICT program INNODERM, we developed mesoscopic optoacoustic imaging for dermatology diagnostics. Termed raster-scan optoacoustic mesoscopy (RSOM), the method can image previously invisible ❶ pathophysiological/oxygenation and ❷ morphological features of the skin at depths of 1-5mm. RSOM has already shown clinical diagnostic value in dermatology and, fuelled by INNODERM, has been commercialised and globally placed by iThera Medical. WINTHER builds on this success. While INNODERM focused on diagnostic dermatology, it has become apparent that RSOM can also assess progression and therapy not only in skin but also in cardiovascular diseases and diabetes. However, to achieve this, RSOM should be able to assess endothelial function, ability that it is not yet available. WINTHER will build next-generation fast RSOM (F-RSOM), operating up to two orders of magnitude faster than state-of-the-art RSOM, enabling it to assess not only ❶,❷ above but also ❸ endothelial function. Using the skin as a window for disease assessment and aided by a modern computation framework, based on deterministic and artificial intelligence algorithms, F-RSOM aims to improve the clinical accuracy of RSOM and shift the paradigm in therapeutic monitoring of cardio-metabolic diseases and inflammatory skin conditions, strengthening Europe's leadership in photonics and in personalized medicine. The project is driven iThera Medical with a strong history of commercializing optoacous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self-Assembled Virus-Like Particles from Polyferrocenylsilane-Based Polymers and Viral Capsid Proteins: Fabrication, Surface Engineering and Applications' to be submitted under Seventh Framework.

assistant: **Abstract**

The capsid proteins of viruses have been shown to organize around a variety of non-biological polyanions, in a similar way that proteins assemble around RNA genomes, to form virus-like particles (VLPs).  Metal-containing polymers such as polyferrocenylsilane possess additional interesting physical and chemical properties and may yield VLPs possessing very different morphologies and more diverse functionalities on co-assembly with capsid proteins. In a similar manner to almost all nanoscale objects, VLPs generally exist in the solid state but not in the liquid phase, because the scales of these systems are typically larger than the range of attractive interactions between such nanostructures.  This situation comes with limitations regarding both storage and product formulation.  Due to the recent development of liquid proteins via the surface engineering techniques, interest in the phase behavior of bionanomaterials has grown rapidly.  The proposed research focuses on the fabrication and surface engineering of responsive VLPs through the self-assembly of polyferrocenylsilane-based copolymers and viral capsid proteins.  This project is highly interdisciplinary and the project objectives will be accomplished by the proposed award of a Marie Curie Fellowship to a highly talented young scientist from China, Dr. Hongjing Dou. She has considerable expertise in the area of  bionanomaterials and in biomedical science. The proposal involves her working at the School of Chemistry at the University of Bristol in the UK together with Prof. Ian Manners, who has expertise in the field of synthetic metallopolymers such as polyferrocenylsilanes and also self-assembly, and cosupervisor Prof. Stephen Mann, an expert in bio-inspired chemically-derived routes to complex materials and a pion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genealogical Thinking in Nietzsche's Wake (19th-21st Centuries)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Since a few decades, “genealogy” has become a philosophical keyword: self-proclaimed genealogies of X or Y are offered every day (where X can be democracy, modernity, spiritualism, Europe, and so on). Admittedly, the word “genealogy” doesn’t mean much more than “genesis” in most of these contexts. But even this loose understanding of the term seems to echo a philosophical tradition which grew out of Nietzsche’s Genealogy of Morals and of some influential readings of it: especially those of Deleuze and Foucault . The present research proposal aims at interrogating this tradition. To circumscribe a real tradition and not a mere intellectual fashion, the genealogical corpus must be defined as a history of explicit receptions of Nietzsche. Thus, Foucault, Judith Butler and Bernard Williams are three major genealogists in the strong sense: they have all engaged in a creative dialogue with the Genealogy of Morals, around the idea of “problematizing” our present norms and values through history . In doing so, however, they have also reinterpreted what Nietzsche initially meant by a “genealogy of morals”. Hence, it seems both needful and worthwhile to write a history of genealogical thinking in Nietzsche’s wake. This history could also help clarify what philosophical genealogy can achieve today in the fields of social and political philosophy, ethics, epistemology and gender studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Establishing genetic code expansion as a tool to study neuronal circuit function in an animal' (UAAWORM), addressing dissemination and exploitation.

assistant: **Impact**

We pioneered technologies that allow the site-specific introduction of chemically synthesized unnatural amino acids (UAA) into a chosen protein within the context of a multicellular organism - the nematode worm C. elegans. The foundational technology for this advance is genetic code expansion.In its most simple form, genetic code expansion to incorporate UAA into proteins requires an orthogonal aminoacyl-tRNA synthetase/tRNACUA pair to be introduced into the host organism. The orthogonal aminoacyl-tRNA synthetase must specifically recognize an UAA and use this amino acid to specifically aminoacylate its cognate orthogonal tRNACUA, which is itself not a substrate for endogenous synthetases. The aminoacylated tRNA then decodes an amber stop codon introduced into a gene of interest at a specific site.Our proposal is at the intersection of synthetic multicellular biology and organismal neurobiology. We aim to engineer photo-activateable proteins in C. elegans neurons by site specifically incorporating photo-caged unnatural amino acids. This will allow us to develop tools to: i) control within an intact, freely moving animal the activity of any desired single neuron or group of neurons, and ii) eventually control the chemical and electrical synaptic connectivity between neurons. We will then apply this technology to investigate how neuronal circuits generate behaviour.In addition and complementary to the development and application of neurobiological tools we will further improve the coding capacity of the worm’s protein synthesis machinery.


**Keywords:** Genetic code expansion, synthetic multicellular biology, neuronal circuit function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhanced Learning Experience and Knowledge Transfer' (ELEKTRA).

assistant: **Concept**

ELEKTRA will develop an innovative design and development methodology for producing e-learning experiences. This methodology will be derived from combining State of the Art (SoA) research in cognitive science, pedagogical theory and neuroscience with best industrial practice in computer game design and e-learning software design. As a demonstrator ELEKTRA will produce a 3D virtual reality based virtual learning environment, in which learners can experience learning experiences as rich as gaming experiences. Through these enhanced learning experiences learners will be able to actively interact with and visualise the relationships between concepts and engage in multimodal approach of concepts. The anticipated outcome of ELEKTRA is new approach to design and development of e-learning experiences that is underpinned and supported by research and evaluation findings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Contaminated soil - assessment and remediation technologies to protect the groundwater' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Taking part in research in our inter-related group with twelve years of experience will offer an extremely fruitful knowledge transfer. The cleaning of contaminated soil is a really interdisciplinary task for chemists, biologists and engineers. Our DFG research centre is the only one with this topic in Germany , where the cleaning of contaminated soil was an demanding task in the past ten years and is further on. The received results and know how will be very useful for our fellows from other European countries now focussing their interest on soil and groundwater quality . Getting familiar with the following specialities of our group, which are unique at least in this combo- nation in Europe, is the most important benefit and impact of the research training: Fast on-site analysis by GC/MS, XRFA or heavy metals speciation with synchrotron radiation: XAFS, ecotoxicological evaluation by bioassays, bound residues and degradation analysis, and the complete- ness of chemical and especially microbiological treatment with extreme thermophilic microorganisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Gender, Migration and Intercultural Interactions in the Mediterranean and South East Europe: an interdisciplinary perspective'.

assistant: **Innovation**

Ge.M.IC will study “Cultural Interactions in a European Perspective” through a tripartite conceptual and methodological approach, whose aim will be to identify links between migration, gender and intercultural interaction, as it is in the meeting place of these three dimensions that some of the most important cultural developments in Europe take place. Ge.M.IC will approach these questions from a critical perspective emphasizing in particular the impact of migrant mobility and cultural diversity on gender relation in host, transit and sending societies. Research will be of an interdisciplinary nature in accordance with the broad range of expertise of the researchers collaborating in the project. The organization of work will reflect the inter-ethnic and interdisciplinary character of the consortium focusing both fieldwork and analysis on six thematic areas of study, rather than on national case studies: representations of national identity and the media, education, urban social spaces and movements, religion, violence, and the family. Ge.M.IC will generate new and important insights in these thematic areas, taking advantage of the diverse areas of expertise of different researchers and their mutual commitment to studying gender and addressing issues of gender equality as a central aspect of research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Disruptive imaging technology for accurate and painless breast cancer diagnosis' (GI-BCT).

assistant: **Innovation**

Breast cancer is the most prevalent form of cancer in women, as 1 in 9 women are affected and 1 in 30 will die from the disease. Early detection is essential to reduce the mortality, thus countries have established routing screening programs. The problem is that main screening procedure of mammography is painful for patients, produces high rate of false positives for women with dense breast tissue, provides limited contrast, low-resolution and poor tissue discrimination properties. False positives lead to performing unnecessary therapeutic procedures. Also cancer in dense breasts is missed out by mammography, lowering survival outcomes when discovered in later stage. GratXray is entering the 3,56 BEUR size breast imaging market with our disruptive grating interferometry-based breast computed tomography – GI-BCT technology. GI-BCT will provide painless, efficient and precise breast cancer imaging. The breast will be scanned in its natural state in 3D, without compression and contrast agents, yielding images with a much higher contrast and better resolution. Thus saving €1,85B in healthcare costs in Europe and US by avoiding recalls, €640 000 from machinery costs for breast centers and potentially save treatment costs in the amount of €95 000 per patient.We have worked for the past 15 years in GI-BCT research and have a solid patent portfolio of 8 granted patents. Currently, we have demonstrated our technology in operational environment, and we are ready to start first clinical trials in 2D with the goal to make first sales in Q1 2021. We have formed a team that combines strong scientific, industry and user know-how. We estimate that a further investment of €5M and 3 years is required to reach the commercialization stage. We estimate that in year 6 we have hired 50 employ