RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'InSilc: In-silico trials for drug-eluting BVS design, development and evaluation'.

assistant: **Concept**

The aim of InSilc is to develop an in-silico clinical trial (ISCT) platform for designing, developing and assessing drug-eluting bioresorbable vascular scaffolds (BVS), by building on the comprehensive biological and biomedical knowledge and advanced modelling approaches to simulate their implantation performance in the individual cardiovascular physiology. The InSilc platform is based on the extension of existing multidisciplinary and multiscale models for simulating the drug-eluting BVS mechanical behaviour, the deployment and degradation, the fluid dynamics in the micro- and macroscale, and the myocardial perfusion, for predicting its interaction with the vascular wall in the short- and medium/long term. InSilc goes beyond the design and development of ISCT and lays on the generation of in-silico models for obtaining quick and informed answers to several “What if” scenarios. “Virtual” patients would be given a “virtual” drug-eluting BVS, for observing the performance of the scaffold, assess and quantify the intended effect, with a deeper understanding than normal trials can provide. By integrating the information obtained from different in-silico predictive models, InSilc will: (i) assist in the development, assessment and optimization of the drug-eluting BVS and deliver accurate and reliable information to the Stent Biomedical Industry, (ii) assist the interventional Cardiologists in improving the surgical process of drug-eluting BVS implantation, support them in the clinical assessment and reduce the complications of suboptimal scaffold performance. By introducing computer simulations for establishing the safety and efficacy of drug-eluting BVS, InSilc aims to lower development costs and shorten time-to-market, reduce, refine, and partially replace human clinical t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fundamental Physics Using Black Widow, Redback and Transitional Pulsar Binaries' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

I will use an innovative coupled approach to facilitate a paradigm shift in the use of neutron stars as a probe of high energy physics. The compactness, rapid rotation and large magnetic fields of neutron stars make them, along with black holes, the most extreme objects found in our Universe. Neutron stars are therefore formidable laboratories to study fundamental physics, as they allow us to probe regimes simply unavailable to Earth-based experiments. However, in spite of their potential utility, there are still a number of important outstanding questions in this field. Key amongst these are: What is the neutron star equation of state?  How do neutron stars become the fastest rotating stellar objects in the Universe? How do millisecond pulsars affect their environment? Answering these questions has a broad multi-disciplinary impact, far beyond the field of neutron star research alone; however, at present our ability to answer these questions is limited by cherry picking individual objects for study. In this proposal I describe how I will move away from the biases inherent in the idiosyncratic nature of particular sources to a comprehensive population analysis, and specifically, how I will use a particular class of neutron star systems, known as “spider binaries”, to discover the most massive and the fastest spinning neutron stars that exist. Such extreme cases are of crucial importance for constraining the neutron star equation of state and thus determining the boundary for stellar mass black hole formation. This knowledge in turn can tell us about possible phase transitions of matter at high densities and provide observable quantities that can then be tested against Earth-based experiments, feeding back into high energy physics theories. I will achieve these goals thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Large scale manufacturing technology for high-performance lightweight 3D multifunctional composites', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The goal of 3D-LightTrans project is to provide groundbreaking, highly flexible and adaptable low-cost technologies for manufacturing of 3D textile reinforced plastic composites (in the following referred to as textile reinforced plastics or TRP), including innovative approaches for the individual processes and its integration in complete manufacturing chains, which will enable to shift them from its current position in cost intensive, small series niche markets, to broadly extended mass product applications, not only in transportation, but also in other key sectors, like health and leisure.To fulfil this goal, 3D-LightTrans manufacturing chains will based on hybrid yarn incorporating thermoplastic matrix material, processed to deep draped multilayer textiles and multifunctional 3D-textile constructions, which will be fixed to dry pre-forms and finally, processed into composites by thermoforming. By integrating these new, innovative process steps with full automation in -nowadays mostly manually performed- complex handling operations, it will be possible to obtain a fully automated and highly adaptable manufacturing chain. 3D-LightTrans will open the way to a totally new concept for the design, manufacturing and application of composites for low-cost mass products in a wide range of sectors.The Consortium brings together multidisciplinary research teams involving five industrial stakeholders from machine tools and machine automation (P-D Glasseiden, Van de Wiele, Lindauer Dornier, Coatema) and several OEM active in the field of processing of flexible materials and composite manufacturing, including Federal Mogul, among others, as well as from the application sector (FIAT and Bentley), and extensive expertise from well known research specialists in the area of materials,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Eliminating Waste and Boosting Productivity in Transnational Technology Transfer'.

assistant: **Objectives**

The IRC (Innovation Relay Centres) network has been operating for 10 years. Although the IRC has established itself as the most important tool in Europe for Transnational Technology Transfer (TTT), there are still issues that remain to be improved, such as the cost efficiency of achieving TTT agreements.The objectives of the LeanTTT project is to improve efficiency in the IRC network so it can fulfil its overall objectives which is to provide cost-effective TTT services to improve competitiveness in local industry through innovation, and thereby, stimulate the creation of new companies and new jobs. The objective of the LeanTTT project is to develop a methodology to make best use of new and available IRC practices and to reduce unnecessary or excessive activities in the TTT process.The LeanTTT will develop a methodology based on the world famous Toyota Production System (TPS, lean production) to measure and improve productivity, lead-time and quality in the TTT process. Using available tools, value-adding and non value-adding operations (waste) will be identified with the purpose of minimising or eliminating wastes in the TTT process. Thus a step-by-step program of improving productivity and reducing lead-time will be developed. The LeanTTT project will initiate at least 25 such continuous improvement projects.The LeanTTT project will develop a comprehensive methodology for improving overall efficiency, speed and quality of the TTT process using Lean techniques. The method will be implemented and tested in at least 10 IRCs. A learning package will also be developed that will enable all IRCs and other network players working with TTT to implement a more efficient process and to adopt a culture of continuous improvements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Elucidating natural bilayer lipid environments' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Excising a membrane protein from its natural environment, preserving the lipid bilayer, and characterising the lipids that surround it is the ‘holy grail’ of membrane protein biophysics.  However, with some 40,000 different lipid structures the challenges we face in understanding selective binding arise not just from the complexity and dynamics of the lipidome, but also from the transient nature of protein lipid interactions. To overcome these challenges we will take mass spectrometry (MS) into a new era, allowing, for the first time, the study of proteins in an environment as close as possible to the natural one. To do this we will (i) characterise protein lipid interactions by employing a high resolution Orbitrap mass spectrometer developed in-house, specifically for membrane proteins, (ii) capture the native lipid environment in vehicles suitable for use in conjunction with MS, and (iii) establish a new platform to be known as integral membrane protein desorption electrospray ionization (impDESI). Designed and built in-house impDESI is capable of releasing membrane proteins from surfaces directly into the mass spectrometer (MS). We will develop impDESI for membrane mimetics, and subsequently portions of natural membranes, enabling us to extract proteins with oligomeric state preserved and native lipid binding intact. The development of impDESI, in conjunction with high resolution Orbitrap MS, and coupled with the optimisation of membrane mimetics, has the potential to radically transform our understanding of native lipid binding, not only directly, but also temporally and spatially. Together these advances will answer key questions about how lipids modulate protein interfaces, occupy different binding sites, modulate membrane protein structure and modify function in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synergizing Neural Network Theory and Combinatorial Optimization via Extension Complexity' (NeurExCo).

assistant: **Innovation**

Artificial intelligence is changing our lives. Artificial neural networks are present and entering various fields of modern technology such as medicine, engineering, education and many more. Even a small-scale theoretical understanding of why and how neural networks succeed in practice can have a considerable impact on the future development of such technologies.In contrast, combinatorial optimization is a well-established discipline at the intersection of mathematics and computer science, dealing with classical algorithmic questions like the Shortest Path or Traveling Salesperson Problems. A powerful tool to study structural and algorithmic properties of combinatorial optimization problems is polyhedral geometry. For example, the geometric notion of extension complexity classifies how well a specific problem can be expressed and solved via an extremely successful general-purpose technique called linear programming.Recent developments show that polyhedral theory can also be a powerful tool to achieve a better mathematical understanding of neural networks. The overall goal of this project is to significantly intensify the connection between neural networks and polyhedral theory, using the concept of extension complexity. This new symbiosis will advance both, the theoretical understanding of neural networks as well as the fundamental understanding of classical combinatorial optimization problems. On the side of neural networks, we expect to obtain new bounds on the required size and depth to solve a given problem, serving as an explanation of why large and deep neural networks are more successful in practice. Furthermore, we expect contributions to a more refined understanding of the computational complexity to train a neural network. On the side of combinatorial optimiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ImmuNogenomics TArgeting Cancer' under Horizon 2020.

assistant: **Concept**

Melanoma is the most aggressive, treatment-resistant and lethal type of skin cancer. Its increasing incidence worldwide emphasizes the need for new treatment strategies. Major recent breakthroughs in melanoma therapy have highlighted the role of immune T cell-mediated responses against tumor cells, showing that immune-system recognition of neo-antigens on cancer cells serves as a distinctive immunological signature. However, current strategies to identify neo-antigens are biased, costly and time-consuming. Directly addressing this major therapeutic limitation, this PoC project is aimed at commercializing an innovative tool, called INTACt, for designing highly personalized therapies for melanoma patients, ones that efficiently target the composition of patient-specific neo-antigens that arise as a consequence of mutations in a patient’s melanoma genome. INTACt is designed to identify neo-antigens in a high-throughput, systematic and cost-effective manner in cell lines, fresh tumors, patient-derived xenografts and plasma. INTACt will further identify the patient neo-antigen-reactive T cells to then be returned to the patient, using neo-antigen-specific T cells or RNA vaccines. Such personalized targeting of the patient’s melanoma genetic landscape is key to a significantly improved mortality. Unlike existing therapeutic strategies, INTACt may be considered the ultimate personalized immune therapy for the treatment of melanoma patients to be expended to other cancer types. This patient-specific tool will significantly lower patients’ economic and psychological burden caused by unnecessary chemotherapy and targeted therapy. INTACt also holds the promise of realizing value from enormous past investments in drug candidates that were eliminated due to person-specific toxicitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Large-scale identification of Coxiella burnetii virulence factors' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Coxiella burnetii is an obligate intracellular gram-negative bacterium responsible of the zoonosis Q fever, a disease that manifests as an acute flu-like illness. Due to its high infectivity it has been classified as a class B biothreat. In natural infections Coxiella mainly targets macrophages whereas in vitro is capable of infecting a wide variety of cell types. As several other pathogens Coxiella replicates in a large phagosomal vacuole, but differently from any other known pathogen, Coxiella has the capacity of thriving in a parasitophorous vacuole which is biochemically indistinguishable from lysosomes. Despite the interest that Coxiella infections raise, its obligate intracellular nature has hampered the research activity due to the impossibility of genetic manipulation and growth in broth. The mechanisms of subversion of host functions remain therefore obscure and the number of Coxiella virulence factors identified is limited to the bacterial LPS. The recent characterization of a specific growth medium that allows axenic growth of Coxiella opens the way to genetic engineering of the bacterium. The aim of this project is the large-scale identification of Coxiella virulence factors by generating a bank of mutants by transposon mutagenesis. This will be coupled to the set up of robust high throughput screens to identify phenotypes that will allow the characterization of virulence factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Restoring a normal life and dignity for women and men suffering from severe Stress Urinary Incontinence'.

assistant: **Objectives**

Severe stress urinary incontinence affects hundreds of millions of women and men in the world. It is an ignored public health problem, as it is often hidden. For those who suffer from it, it turns their lives into a living hell. Existing solutions are unsatisfactory. For men, manual artificial urinary sphincters (AUS), require the scrotum to be manipulated for each voiding, sometimes with the help of a relative for dependent people. It's humiliating. These devices, are associated with a significant rate of revision and explantation, notably because of manually manipulated implantable components and the constant pressure exerted on the urethra often leading to erosion and atrophy. The patient is plunged back into the hell of incontinence for good. For women, the most commonly used solution is mesh sling, initially developed for cases of prolapse. This solution leaves 15% of women incontinent, with a further 5% suffering serious, irreversible damage. To such an extent that they are the subject of over 100,000 lawsuits in the USA.  Women are left without a safe, convenient and effective solution.Severe incontinent people urgently need a safe and decent solution. We are developing the first smart artificial urinary sphincter, designed to solve all the drawbacks of current devices. UroActive™ is: - connected: voiding is done by remote control or by gently tapping on the abdomen (no more genitals manipulation) - self-adjusting: the occlusive pressure is automatically adjusted depending on patient's position and activity - personalized: the surgeon can wirelessly adjust device parameters after implantation - secure: if the patient cannot control the device or loses consciousness, the device automatically opens to prevent overpressure in the bladder and kidney injury. UroActive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project '5th Generation connected and automated mobility cross-border EU trials' (5G-ROUTES), addressing dissemination and exploitation.

assistant: **Impact**

5G-ROUTES is a 5G-PPP Phase 3 project whose aim is to validate through robust evidence the latest 5G features and 3GPP specifications (R.16 & R.17) of CAM under realistic conditions. In particular, it will conduct advanced large-scale field trials of most representative CAM applications to demonstrate seamless functionality across a prominent 5G cross-border corridor (Via Baltica-North), traversing Latvia, Estonia and Finland. This will help to boost confidence and accelerate the deployment of 5G-based interoperable CAM ecosystems and services throughout Europe. It also aims at validating 5G as a true enabler of innovative CAM services that cannot be realised by today’s technology. Specifically, 5G-ROUTES will provide: (a) validation of >150 network, business and service-level KPIs for 13 diverse CAM use cases that require 5G performance capabilities, covering several V2X scenarios in automated cooperative, awareness and sensing driving. 5G-ROUTES also focuses on uninterrupted infotainment passenger services on the go and multimodal services in the context of complete connectivity-enabled ecosystems around passengers and cargo over 3 different modes of transport (vehicles, rails and maritime); (b) innovative AI-based technological enablers for facilitating the execution of the field trials. Several scenarios will be considered for each use case covering cross-border, cross-telecom operators, cross telco-vendors, integrated cross terrestrial-satellite and cross-transport-mode settings. These will be incrementally validated, starting from lab trials, followed by localised large-scale trials at strategic cross-border locations (Valga city, Tallinn & Gulf of Finland) and finally in larger-scale trials covering significant portions of transport routes along the selected corr