RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regulation and consequences of LRRK2 phosphorylation, a path to Parkinson’s disease therapy and diagnostics' (RECOLOR), addressing dissemination and exploitation.

assistant: **Impact**

Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, currently incurable. Studies in the PD field show that leucine-rich repeat kinase 2 (LRRK2) is both a major player in PD pathogenesis and a promising PD therapeutic target. LRRK2 functions in health and disease are not defined; however the applicant and others have shown that LRRK2 phosphorylation is the key to understanding LRRK2 biology. This project’s goal is therefore to understand the role of LRRK2 phosphorylation in PD by pursuing 3 specific aims: 1) elucidate the regulation of LRRK2 phosphorylation by phosphatases, 2) determine LRRK2 phosphorylation downstream phenotypes in cellular models through transcriptome profiling, protein translation profiling and protein tau related phenotypes, and 3) verify these findings from experimental models in PD biosamples. The project builds on the applicant’s extensive expertise in the field of LRRK2 biology (24 papers in 8 years) required for aim 1 and will leverage expertise on PD biosample analysis of the host institution (training for aims 2 and 3). The research program will be performed at the JPA research center (a mixed Inserm-Lille 2 University-Lille University Hospital center for excellence research, Lille, France), with a network of strategically chosen collaborating research groups locally and internationally, coordinated by the applicant. The study of LRRK2 phosphorylation in experimental models and translation of experimental results to clinical samples will reveal the most relevant molecular mechanisms of LRRK2 in PD which can be exploited in follow up work as diagnostic biomarkers and targeted for disease-modifying therapy. Given the importance of PD and neurodegeneration in Europe, this project is fertile ground for a high visibilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enactive model of aesthetic perception through rhythm and entrainment' (ENAMARE).

assistant: **Concept**

ENAMARE is an innovative project that will study the functionality of the aesthetic constituent of general perception through the use of an enactive approach and conceptual tools from the dynamic systems theory. This will be done through the elaboration of a interdisciplinary model based on interactional loops between environmental and bodily rhythms mediated by the phenomenon of entrainment and their implications on processes of sense-making and engagement. This project will address general perception, thus, as a temporally extended process arising from dynamic interactions between agent and environment with an inherent and vital aesthetic component involved in our constant reappraisal of the world and ourselves. In coherence with enactivism, the theoretical framework will be grounded on philosophy but will integrate research results and theory from biology and neurosciences as well.It is a particularly timely moment to conduct ENAMARE. Despite relevant researchers asking for projects addressing this topic and interdisciplinary research focused on different aspects of cognition, there has yet to be a thorough and comprehensive research on aesthetic influence over everyday perception. It would lead to a better understanding on the reciprocal effect and influence between environment and agents, and it would also enhance European research in fields as diverse as urbanism, education or artificial intelligence.My background, which covers biology, neuroscience and humanities, puts me in a unique position to develop a project that will grant me methodological expertise and theoretical knowledge. This will help me develop into a solid interdisciplinary researcher by successfully integrating all sides of my previous academic formation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissecting the Genome-wide Action of Interferon Regulatory Factor 4 (IRF4) in Melanoma' (IRF4), addressing dissemination and exploitation.

assistant: **Impact**

Interferon regulatory factor 4 (IRF4) is a transcriptional regulator with critical roles in lymphocyte development and function. We have recently shown that cells from a poor-prognosis subtype of lymphoma and multiple myeloma show  non-oncogene addiction to IRF4. Using integrative genome-wide strategies, we have identified the gene regulatory program that IRF4 controls in these cancers.In several studies, high IRF4 expression was consistently observed also in cells derived from the melanoma type skin cancers at both mRNA and protein level.  A survey of multiple gene expression profiling studies show that IRF4 expression is significantly high in melanoma.  In addition, several genome-wide association studies identified IRF4-linked polymorphisms contributing to pigmentation, nevi count and risk of developing melanoma. These studies, taken together with our first-hand understanding of IRF4’s crucial role in B-cell cancers, strongly implicate a direct role for IRF4 in melanoma. However, the extent and molecular mechanisms of the role of IRF4 in melanoma and melanocyte biology have so far not been reported.We are initiating a project to study the role of IRF4 in melanoma cells using cellular, molecular, and genome-wide approaches as the first segment of my research program aimed at investigating the critical gene regulatory and epigenetic networks in cancers. Specifically, we will study the requirement of IRF4 in the tumorigenicity of melanoma cells. Further, we aim to employ genome-wide expression and localization (ChIP-Seq) assays to identify the genes and downstream pathways controlled by IRF4 in melanoma, and test their roles in melanoma development and progression. Melanoma incidence has been on the rise, and advanced forms of melanoma are mostly resistant to current th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Preparatory activities for the implementation of the European  X-ray Free-Electron Laser Facility'.

assistant: **Concept**

The objectives of the Preparatory Phase of the European X-ray Free-Electron Laser Facility are: a) to provide the technical, legal and financial documents which are necessary for the foundation of this new research infrastructure in Europe.  b) to advance as far as possible in the specification, research and development, prototyping and industrialization of buildings, technical infrastructure, technical components, in order to start the construction phase with  maximum probability to conclude it succesfully on time and budget. c) to mobilize the potential users community, which is multidisciplinary and possibly composed by scientists experienced with synchrotron light sources, with ultrafast lasers, and ultrafast electron diffraction.  As far as the objectives a) are concerned, the Technical Design Report is completed, and nearly final drafts of the Convention and of the Articles of Association are available. Still missing are the basic contractual framework to regulate in-kind contributions from participating countries, and the framework contract regulating the relationship between the new international facility and the host laboratory (DESY), which are among the deliverables of the present proposal (Work Packages 4 and 5). As far as the objectives b) are concerned, the work is very advanced for accelerator and infrastructure design, where DESY personnel is engaged; for instrumentation and experiments development, the necessary personnel is lacking. One goal of this proposal is the immediate recruitment of an international staff, supported by the EC funding, in order to advance in this domain, and to impress a strong international flavour to the enterprise, which has been so far mostly carried out as a DESY activitity (Work Package 3). As far as the objectives listed u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Legal rights and the political economy of debt and austerity in Europe' (JUSECON).

assistant: **Innovation**

This research project will explore the Greek debt and austerity crisis to consider what it discloses about the influence of European political economy on the principles and practices of legal rights, and with what implications. The term ‘legal rights’ in this work includes human rights as well as the international rights of states and these respective approaches underpin the two component parts of this study. This is a multidisciplinary study that assumes the validity of law as a means of advancing the cause of justice, but recognises that it is shaped in important ways by other dominant narratives. This study is an exploration of that clash of narratives and its effects on justice in Europe.The first part of this research project is animated by the idea of ‘social rights as fiscal risks’, an idea that finds expression in the latest Memorandum of Understanding (MoU) of August 2015 between the international creditors and Greece. In exploring the means through which human rights safeguards are being made to disappear under fiscal targets, a case study on the influence of austerity reasoning on what constitutes the public interest as a human rights concept will form part of the first section of the project. The second part of this research project will explore the legality of the bailout agreement when measured against the principle of economic self-determination. A preliminary review of the same MoU would seem to offend any reasonable form of economic self-determination, a principle with a long pedigree in international law and demands by states of sovereignty over their economic affairs. Taken together, the two studies will expose ways in which rights are being shaped by the intellectual justifications, logic and practice of economic and financial policy as played out un
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mathematical models of bone externally excited remodelling' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

For describing  complex systems as bone tissue, with their inner interactions and their interactions with environment the mathematical models become even more complex, that puts demands on theories, methods and assumptions used and the efficiency of numerical methods employed for solving as well as the management of data. The complexity of bone models depends not only on the number of parameters describing different biochemistry and  Multi-physics influences but also on different time scales and rate of periodicity of processes involved. In structural analysis non-linearity plays important role for realistic description of real world phenomena. Incorporated the parametric nonlinear analysis of periodically excited hybrid systems into a structural models of bone would be a great advantages for prediction of a more realistic situation for description of the bone mass distribution, delay in the osteoblasts and osteoclasts coupling, osteocytes transferring of signals and more other issues related to the bone adaptively and strength. The aim of the project would be that on the base of existing level of  known parameters in bone turnover  guided by external loading provide an analytical approach to be solve and interpreted for real description and prediction of bone adaptive behavior. Hybrid systems treat cellular level as discrete system of particles described with system of coupled ordinary differential equations and environmental conditions as a continuous system described with a system of coupled partial differential equations affected with different external signals. The established, measured and explored model will also give an approach closer to the realistic situation and real needs and suggestions for patients with bone problems but also for those who want to have he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ecological memory and extinction debt: soil biota responses to land use legacies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The impact of land use change on various organisms, including plants, birds, mammals, amphibians, and arthropods, leading to local extinction debt, has been widely recognized. With the rapid transformation of landscapes due to agriculture, it is essential to assess the delayed response of soil organisms to these changes, known as the extinction debt.The concept of extinction debt suggests that a species may initially survive habitat changes but could eventually become extinct without further modification to its habitat. While it is known that land use can have lasting effects on soil properties and microbial communities, specific research on extinction debts in soil communities has been lacking. To address this gap, a comprehensive study will be conducted using data from over 1000 agricultural field sites in Estonia, including detailed land management information and molecular IDs of various soil-dwelling organisms.Cutting-edge analytical methods will be employed to evaluate the extent of ecological memory in soils, providing valuable insights for land managers and policymakers. This research aims to offer unique evidence of the impact of land use legacies on soil communities and identify the soil biota most vulnerable to land use changes. By integrating knowledge from agronomy, molecular ecology, community ecology, and soil biology, this interdisciplinary research seeks to understand how past land use legacies influence the current and future composition of soil organisms and, consequently, soil function.


**Keywords:** Soil biota, metabarcoding, network analyses, multitrophic, monitoring, agroecology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neural Engineering Transformative Technologies' (NETT).

assistant: **Concept**

Neural Engineering is an inherently new discipline that coalesces engineering, physics and neuroscience for the design and development of brain–computer interface systems, cognitive computers and neural prosthetics. For the implementation of future transformative technologies a new breed of young researchers must be trained to integrate ideas and skills from a broad range of disciplines.NETT is composed of seven full network partners and ten associated partners including one international industrial company and eight SMEs.  NETT will provide a European focus for the development of those aspects of Complexity Science most relevant to Neural Engineering, and ensure that we do not fall behind research in the US and Japan.  We have identified some of the key challenges in this field and designed a set of inter-related multi-disciplinary projects that, by combining the skills of NETT members will generate transformative technologies such as novel speech recognisers, neural- inspired laser networks for information processing and robots withcognitive skills.To address key priority areas of FP7 in multi-disciplinary research, NETT will train ESRs and ERs using a structured, industry-focussed selection of training courses, with leading expertise in mathematics, physics,  neuroscience and bioengineering from academia and the private sector. Each ESR will benefit from a secondment to another host country and an internship with an associated partner on problems of genuine real-world relevance. In this way ESRs will acquire a unique set of essential multi-disciplinary skills that will enhance research activity in the ERA and improve their career perspectives in both the public and private sectors.NETT is thus a Marie-Curie ITN whose activities are designed to benefit the development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sketching Audio Technologies using Vocalizations and Gestures', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Sketching is at the root of any design activity. In visual design, hand and pencil are still the primary tools used to produce a large variety of initial concepts in a very short time. However, in product and media design the sonic behavior of objects is also of primary importance, as sounds may afford seamless and aesthetically pleasing interactions. But how might one sketch the auditory aspects and sonic behavior of objects, in the early stages of the design process? Non-verbal sounds, more than speech, are naturally and spontaneously used in everyday life to describe and imitate sonic events, often accompanied by manual expressive gestures that complement, qualify, or emphasize them. The SkAT-VG project aims at enabling designers to use their voice and hands, directly, to sketch the auditory aspects of an object, thereby making it easier to exploit the functional and aesthetic possibilities of sound.  The core of this framework is a system able to interpret users' intentions trough gestures and vocalizations, to select appropriate sound synthesis modules, and to enable iterative refinement and sharing, as it is commonly done with drawn sketches in the early stages of the design process.  To reach its goal, the SkAT-VG project is based on an original mixture of complementary expertise: voice production, gesture analysis, cognitive psychology, machine learning, interaction design, and audio application development. The project tasks include case studies of how people naturally use vocalizations and gestures to communicate sounds, evaluation of current practices of sound designers, basic studies of sound identification trough vocalizations and gestural production, gesture analysis and machine learning, and development of the sketching tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Protease Activated X-Ray Contrast Agents for Molecular Imaging of Vulnerable Atherosclerotic Plaques and Cancer Development using Spectral CT' to be submitted under Seventh Framework.

assistant: **Abstract**

The major causes of death in the Western world are cardiovascular diseases and cancer. More accurate detection of these diseases will improve clinical outcomes. Thus, we will develop unique X-ray contrast reagents for use in spectral computerized tomography (CT) that bind active proteases to reveal the exact location and stage of cancer and atherosclerosis.Activity-based probes (ABPs) are small molecules that covalently bind to active proteases. Based on our success in developing optical ABPs for non-invasive optical detection of cancer and atherosclerosis, we will focus on two novel types of reagents: (1) ABPs conjugated to the various contrast elements that can be visualized by x-rays. (2) “smart probes” conjugated to different contrast reagents on each side of the molecule to overcome clearance limitations. Protease found in diseased tissue will selectively bind and remove a part of the molecule, changing the physical properties of the bound probe. Thus, different signals from bound and unbound probes could be detected by photon counting spectral CT scanners.Our initial target, cysteine cathepsin proteases, are overexpressed and activated in cancer and arthrosclerosis. The level of active cathepsins correlates with progression of both diseases, thereby serving as a promising biomarker for these pathologies. The “smart probes” are an innovative type of spectral CT agent that will enable high-resolution rapid imaging in humans before probe clearance.Our probes increase imaging sensitivity since the contrast element remains at the desired site.  Moreover, the levels of active cathepsins will reveal critical information regarding disease progression, yielding more accurate diagnoses and improved personalized treatment. For example, these reagents can distinguish between