RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development and design of new types of chemical sensors and sensor arrays for medicine, biology and ecology'.

assistant: **Concept**

Foreseen ResultsAnalyzers for selective determination of different heavy metal ions, immunoglobulines, and some other organic contaminants in the water solutions will be developed as a result of thisEcological problems and needs of the biotechnology developing extensively last years have evolved needs for novel more sensitive, fast, and easy to use tools for studying and monitoring of immune and enzyme reactions. Such techniques are anticipated to result in a drastic improvement in diagnostics of many diseases, in environmental monitoring, etc. During last few years a tendency is observed of biologists and chemists to use surface rather than bulk methods for registration of liquid phase biochemical reactions, i.e. when at least one of the reagents is immobilized at the solid phase interface.Among various methods of surface reaction registration, the optical method {surface plasmon resonance (SPR), optical interferometry (OI)}, and the electrochemical methods (surface potential registration at the electrolyte-insulator interface) are currently considered as being the most promising due to their extreme sensitivity.This project is concerned with:- Studying the effect of the immune and enzyme reactions upon the optical phenomena in planar multilayer structures involving metal and insulator thin films;- Developing the concepts of potential informativity of multi-sensor arrays, including optical and microelectronic basic sensitive elements;- Studying and development methods for immobilization of the protein molecules at the solid surface;- Development and constructing the devices for applications in medical diagnostics, immunology, clinical analysis, ecology, environmental monitoring etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'DEMONSTRATION PROJECT TO REDUCE THE URBAN AIR POLLUTION DUE TO TRANSPORT BY USING NATIONAL GAS FUEL FOR GARBAGE TRUCKS'.

assistant: **Innovation**

The aim of the demonstration project is to :- put these new vehicles into real operating conditions, as they have not been curently operated yet within the Member States of the EU- establish the provisions for a use in normal operating conditions- get over the reticence of cities due to the innovating aspect and their fears as for security of the system.- to make a large information and propagation campaign possible.It must be emphasised that the project presents an exceptional opportunity to inform the general public, as the garbage collecting activity is closely related to the daily preoccupation of the citizens.The project brings together energy suppliers (gas companies) from three countries (Belgium, Sweden and Germany), each of them with a commitment to the project.The gas companies will provide the cities with full technical and/or financial support regarding the construction of the refuelling station as well as for the security aspects of the vehicles, the station and the related infrastructure (garage, workshop).ANTWERPEN : operation of all 4 garbage trucks is satisfactory and without problems. The refuelling station functions well. A CNG metering system will be installed as well as a quick fill section.GÖTEBORG : The 5 test trucks and the 9 belonging to the project are operational without problems.GELSENKIRCHEN : 6 garbage trucks operate satisfactory and without problems. The seventh vehicle has been returned to the manufacturer as problems with the gas system could not be solved adequately and therefore made normal duty impossible.This project is a demonstration project implementing natural gas garbage trucks for which the research and development stage has been completed.It is this new application in normal operating conditions which constitutes the innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Critical information infrastructure research coordination' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Modern society depends nowadays on so called Critical Information Infrastructures (CII). Thus, survivability and dependability of CII have to be considered on a level which goes beyond the level of the local and national stakeholders to guarantee an acceptable level for economy, society, and politics.Thus, the main objective of the Critical Information Infrastructure Research Coordination (CI2RCO) project is to create and coordinate a European Taskforce - to encourage a co-ordinated Europe-wide approach for research and development on Critical Information Infrastructure Protection (CIIP), and - to establish a European Research Area (ERA) on CIIP as part of the larger IST Strategic Objective to integrate and strengthen the ERA on Dependability and Security CI2RCO will focus on activities across the EU-25 and ACC that are essential to be carried out at European level and that require collaborative efforts involving the relevant players of research, research funding actors, policy-makers and CI-stakeholders.This will be accomplished by a set of coordination activities supporting the improvement of networking and coordination of national and European research policies, programmes and funding schemes, namely:- Establishment of a CIIP-network of the relevant players- Preparation and evaluation of a CIIP R&D programmes' inventory in the EU-25 including the development of a roadmap towards a coordinated European CIIP research agenda- Calibration of the CIIP activities within the network- Organisation of workshops/conferences to initiate and foster networks and to evaluate, complete and disseminate results- Provision of a Web-Site to support the network and to disseminate the resultsA major instrument within CI2RCO is an Advisory Board representing the participating EU-25 and AC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Monitor Integrated Safety System' (MISS) targeting Sixth Framework.

assistant: **Abstract**

MISS aims to develop an innovative platform to dynamically sense and predict natural and infrastructure conditions, so to improve safety and efficiency of transport operations in a multi-environmental scenario. This project wants to increase citizens and operators safety by enabling a just in time intelligent computation of an open dynamic road surveillance network a streamlining alerting tasks under the daily duty provided by clerical staff. In this way MISS will pay attention to viability of the system in the long term. The platform will use advanced communication technologies for on-line services as well as high capacity storage devices for off-line services and applications, in addition to a new advanced algorithm to simulate risk assessment. The MISS adaptable platform is a mobile system explicitly designed to monitor rough environmental and infrastructure conditions and it will be integrated with any pre-existing legacy system. It will enable intelligent exchange of structured information between the operational fleet vehicles and the Unified Operative Centre where information will be elaborated and actions planned. The platform will be composed by two main components: 1.an innovative on-board kit: it will be installed on the fleet cars and will include a black box here named MSCU (MISS Storage Communication Unit), where raw environmental and infrastructure data will be stored and elaborated; then, these data will be sent via a radio-communication network to the Unified Operative Centre. 2.an Unified Operative Centre (UOC) where data coming from a monitoring system that is comprised of a set of mobile and fixed distributed devices will be stored and analysed by an innovative simulation algorithm to find a strategy to improve the end-users safety and security and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular mechanisms of amino acid recognition by adenylation domains of the Streptomyces coelicolor A3 (2) coelichelin nonribosomal peptide synthetase' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Non-ribosomal peptide synthetases (NRPSs) are a large family of modular multienzymes that catalyse the biosynthesis of many commercially important microbial natural products. Adenylation (A) domains within each NRPS module selectively bind and activate (by reaction with ATP) the amino acids constituting the peptide. Structure based models of A-domains have recently been developed, which identify potentially important residues for amino acid recognition and facilitate the prediction of new peptide natural pr oduct structures from genome sequence data. The accuracy of these structural predictions and the role played by putative recognition residues will be investigated using the Streptomyces coelicolor A3(2) coelichelin synthetase as a model.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of Tumour suppressor of lung cancer 1 (TSLC1) signalling in lung repair and cancer-associated epithelial-mesenchymal transitions (EMTs)' under Seventh Framework.

assistant: **Concept**

Chronic lung diseases including COPD and cancer account for more than 10% of deaths in European countries and lung cancer remains the most common and most lethal cancer type worldwide. Lung cancer mortality rates have also remained constant for over 40 years, largely due to late stage diagnosis and frequent metastases. Despite these trends the signalling pathways regulating lung cancers remain largely unexplored. Although loss of Tumour Suppressor of Lung Cancer 1 (TSLC1) is implicated in lung cancer metastases its normal lung functions remain entirely unknown. Recently, I determined that the TSLC1 signalling pathway regulates cell proliferation, motility, skin repair, and cancer severity by inhibiting stem cell EMTs. This proposal will determine how TSLC1 regulates lung EMTs to influence repair and disease outcomes. I will correlate TSLC1 expression with EMTs in repairing and diseased lungs, investigate how lung TSLC1signalling influences repair and disease outcomes using transgenic and knockout mice, and identify mechanisms through which TSLC1 modulates lung phenotypes using in vitro overexpression and knockdown studies. This research will elucidate TSLC1 signalling pathway functions in lungs and should suggest new therapeutic opportunities for human lung disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards Engineered Multicomponent Polysaccharide Hydrogels for Surrogate Extracellular Matrices' (EMP-ECM).

assistant: **Concept**

Current effort in the engineering of synthetic extracellular matrixes has focused on installing molecular features (peptides, proteins and bio-interactive polymers) within insoluble scaffolds, either by self-assembly or through covalent modifications of polymer or biopolymer networks. Apart from their direct role in cell interaction, bioactive molecules or peptide sequences affect the hierarchical structural organization and mechanical properties of the resulting material, thus indirectly affecting the cellular response. The overall aim of the proposed research is to develop a fundamental understanding of the structure-mechanical properties-function relations of multicomponent polysaccharide hydrogels used in tissue engineering applications and to apply this understanding in the development of engineering principles that can serve as a generic guide for the design of polysaccharide-based materials for biological applications. Three specific aims will be addressed: 1) Characterization of the interrelations between the chemical compositions of the building blocks (both polymers and peptides) and the resulting structure of the bioactive gels; 2) Systematic investigation of the effect of the different structures on the physical properties of the hydrogel constructs; and 3) Evaluation of the cellular response of the synthesized hydrogels. A methodical study correlating the effect of the bioactive molecules on the resulting hierarchical structure (explored by small angle scattering) and consequent properties will be performed to elucidate the synergetic interactions among the components that determine scaffold effectiveness. A systematic exploration of the polysaccharide type, method of peptide incorporation and gelling parameters will reveal the key factors involved in struc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Extreme Ultraviolet Circular Time-Resolved Spectroscopy' (EXCITERS) targeting Horizon 2020.

assistant: **Abstract**

Chiral molecules exist as two forms, so-called enantiomers, which have essentially the same physical and chemical properties and can only be distinguished via their interaction with a chiral system, such as circularly polarized light. Many biological processes are chiral-sensitive and unraveling the dynamical aspects of chirality is of prime importance for chemistry, biology and pharmacology. Studying the ultrafast electron dynamics of chiral processes requires characterization techniques at the attosecond (10−18 s) time-scale.Molecular attosecond spectroscopy has the potential to resolve the couplings between electronic and nuclear degrees of freedom in such chiral chemical processes. There are, however, two major challenges: the generation of chiral attosecond light pulse, and the development of highly sensitive chiral discrimination techniques for time-resolved spectroscopy in the gas phase.This ERC research project aims at developing vectorial attosecond spectroscopy using elliptical strong fields and circular attosecond pulses, and to apply it for the investigation of chiral molecules. To achieve this, I will (1) establish a new type of highly sensitive chiroptical spectroscopy using high-order harmonic generation by elliptical laser fields; (2) create and characterize sources of circular attosecond pulses; (3) use trains of circularly polarized attosecond pulses to probe the dynamics of photoionization of chiral molecules and (4) deploy ultrafast dynamical measurements to address the link between nuclear geometry and electronic chirality.The developments from this project will set a landmark in the field of chiral recognition. They will also completely change the way ellipticity is considered in attosecond science and have an impact far beyond the study of chiral
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Building Green and Climate Neutral City-Hubs'.

assistant: **Innovation**

CLIMABOROUGH is an Innovation project designed to field test the ClimHub, Climate Sandbox and Climate Service concepts within 12 European Cities engaged in their ecological and digital transition. The project aims to enhance traditional urban and spatial planning approaches through data and knowledge based decision making (including a possible new role for GIS - Geographic Information Systems), including climate services co-production for transitions, cross-city and cross-country pilot co-creation as well as the tactical use of public procurement of innovative solutions. The goal is not just to enhance an open set of tools leveraging climate transition in cities, but also to boost the exchange of experimental good practices, experiences and lessons learnt in this field, to help cities meet climate neutrality by 2050. This will be achieved by the following expected results: (A) building ClimHubs of Cities and solution providers to work on experimentations in real conditions, (B) harnessing the collective intelligence of local stakeholders for collaborative solution development, (C) defining Climate Services as a model strategy to use data and visualisation tools for climate transition, (D) field testing the Climate Sandbox concept as a way to prioritise and facilitate transformation of successfully deployed prototypes into established solutions for climate adaptation and mitigation in cities, and (E) monitoring and assessing the progress in achieving those goals and in implementing a climate neutrality planning scheme. Based on the lessons learnt and successful concept of the H2020 Designscapes CSA, CLIMABOROUGH has the ambition to bridge the gap between design and implementation of urban innovations, particularly in the domain of climate change adaptation and mitigation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional Metagenomics – Harnessing the Biotechnological Potential of Completely Novel Protein Families' (FUME), addressing dissemination and exploitation.

assistant: **Impact**

Today the vast amount of newly published genomic data is generated by metagenomic projects. The annotation of these sequences of organisms, whose existence was not even known before their DNA was extracted from environmental samples, has led to the identification of thousands of new protein families with no detectable homology to any proteins in sequenced and cultivable organisms. While these protein families now make up a major part of the protein universe, we do not know anything about their functions or biocatalytic activity. In this grant application, we propose to lay the groundwork for studying the function of this vast set of proteins and exploit their biocatalytic potential. However, many of the techniques traditionally used to elucidate protein function, such as genetics and “omics”-technologies are not applicable, because the organisms in which these proteins exist are as of yet unknown. Therefore we plan to:1. Computationally analyze the newly discovered protein families to identify one paradigmatic member of every novel family.2. Create an expression-plasmid library of those paradigmatic representatives by de novo gene-synthesis.3. Use this library, combined with the power of Escherichia coli genetics, for specific complementation studies and biochemical assays to assign functions to novel protein families.This combination of synthetic biology and metagenomics will provide the starting point for a novel systematic approach to harness the biocatalytic potential and to understand the function of an unknown sector of biology that has only very recently been discovered.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High-Performance ManyCore Rad-Hard DSP for Computation-Intensive Space Applications' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

MacSpace will research, innovate, architect, design, develop and validate a Non-Dependent High-Performance ManyCore Rad-Hard Processor and DSP Computer for Computation-Intensive Space Applications. When this 33-month project ends the MacSpace Processor will reach computational performance over 10x higher than the emerging alternatives, which merely set 1GFLOPS as minimum required for space DSP.The spaceborne ITAR-free high-performance foundation blocks to be developed by the project partners include: DSP IP core and software tools, MacSpace custom 51.2 GOPS / 12.8 GFLOPS ManyCore DSP processor, FPGA DSP computer prototype and rad-hard-by-design MacSpace prototype chip to provide commercial evaluation of the technology.Building upon the project’s disruptive research innovations marketable technologies, MacSpace will enable future difficult-to-achieve space applications requiring demanding computational performance. Those applications, unattainable with today’s space computers and DSP chips which deliver much less than 100 MFLOPS computing power, include Remote Sensing, Planetary Exploration, Scientific Missions, Navigation and Telecommunications.MacSpace has a strong participation of SMEs and brings together a savvy satellite company, rad-hard ASIC company, DSP industry (IP, software, FPGA, computer), research (benchmark validation, long-term perspective) and a collaborative management service provider.The project will make a major step beyond the state-of-the-art and beyond the joint EC-ESA-EDA Urgent Actions targets, as well as access the commercial market with a full range of recurring products including multiple ASIC versions and DSP computer versions adapted to the various applications. This will enable European space industry to get non-restricted access to high pe