RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic Understanding of Liver Function And Disease' (TISuMR).

assistant: **Concept**

We propose the development of a groundbreaking technology platform that, for the first time, integrates nuclear magnetic resonance metabolomics and micro-imaging with microfluidic perfusion tissue slice culture. This will revolutionise life science research with unprecedented local insight into life processes in intact tissues under highly controlled conditions. We focus on liver tissue slice culture, with the immediate target of elucidating the mechanism of liver damage by drug-induced cholestasis. In the long term, the new technology will find wide application in other tissues, including intestinal, pancreatic, and brain slices. It will form the foundation of a new approach in the life sciences, allowing the detailed metabolicstudy of tissues at the system level.Liver disease is a significant and growing public health problem: 29 million people currently suffer from a serious liver condition in the EU. While the causes for some liver conditions are known, the mechanism of liver damage is generally poorly understood, largely due to the difficulty of studying live liver tissue at the systemic level. The proposed comprehensive research programme leads to a new technological platform for microfluidic tissue slice culture with direct observation of tissue metabolism and transport processes through nuclear magnetic resonance.It joins the expertise and creativity of four leading academic groups and one SME representing the disciplines of micro-engineering, physical chemistry, magnetic resonance, biochemistry, toxicology, and clinical hepatology across three institutions from three EU countries.  Due to its high level of interdisciplinary integration, TISuMR is uniquely able to provide emerging researchers with a career springboard.TISuMR will have a profound impact on wider
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Folding of n-(5'phosphoribosyl - anthranilate isomerase in the presence and absence of groel' to be submitted under Fourth Framework.

assistant: **Abstract**

The Escherichia coli chaperonins GroEL and GroES facilitate protein folding in vivo and in vitro. However, the mechanism of action is not well understood. N-(5'Phosphoribosyl)anthranilate isomerase from E. coli (ePRAI), an alpha/Beta barrel protein, will be used as substrate for the chaperonin. The proposed project will address the following specific aspects of the activity of GroEL: 1) To determine if the chaperonin modifies the folding pathway of ePRAI. 2) To determine the role of ATP and GroES in the folding mechanism. 3) To determine at which stage of the folding pathway and what region of ePRAI interacts with GroEL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Environmentally friendly high speed aircraft'.

assistant: **Objectives**

Business productivity would benefit from a significant reduction in air travel time, especially for long haul flights. The main objective of the HISAC project is to establish the technical feasibility of an environmentally compliant supersonic small size t ransport aircraft (S4TA), through a MultiDisciplinary Optimisation (MDO) approach and focused technological improvements. Based on their experience, the HISAC partners have chosen the following avenue: - Translation of the environmental objectives into qu antified design criteria applicable to an S4TA - Adaptation of numerical models and tools essential to the multidisciplinary design process - Development and validation of the most critical aircraft and engine technologies - Establishment of rules and meth ods to solve key technology integration issues, through shape design - Application of MDO methods, using the results of the above, to obtain: · aircraft specifications compliant with environmental objectives, exploring a broad range of configurations · q uantified trade-offs between aircraft performance and environmental constraints HISAC will provide: - achievable specifications for an environmentally compliant and economically viable small size supersonic transport aircraft - recommendations for future supersonic environmental regulations (community noise, emissions, sonic boom) - enabling technologies, and a road-map for their further maturation and validation, up to a future Proof Of Concept The 37 partners of HISAC consortium are coming from 13 diff erent countries, including one from Poland and four from Russia. Major aircraft manufacturers (Dassault Aviation, Alenia, EADS-M, Sukhoi (SCA) and engine manufacturers (Snecma, Rolls Royce, Volvo, CIAM) associated with five SMEs represent the industrial b ackbone o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Knowledge capture for advanced supervision of water distribution networks' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Water distribution networks are geographically distributed systems, with greater heterogeneity in terms of control structures, management strategies, and with varying geometry (continuous expansion and changes in demand) during their life. Because of these characteristics, water distribution companies face the problem of data and knowledge integration related with control and optimal exploitation. An important step in the course of current control systems is the integration of machine learning capabilities enabling the knowledge capture from large amounts of data collected during system exploitation as well as integrating captured knowledge in a decision support subsystem.WATERNET aims at designing and developing an evolutionary knowledge capture and management system towards the control, optimal operation and decision support of drinking water distribution networks, to minimise the costs of exploitation, guarantee the continuous supply of water through better quality monitoring, save energy consumption and minimise the waste of natural resources.In order to accomplish its goals the WATERNET project will develop an open reference architecture for water distribution networks and a supervision system integrating:- a distributed information management subsystem,- a machine learning subsystem,- an optimisation subsystem and,- a water quality monitoring subsystem.The reference architecture, contributes to the definition of best codes of practice/standardisation of the sector and will help the development and rapid spread over Europe of better water distribution systems. Similarly the supervision system, will offer to the European water distribution companies the possibility to control, manage and decision support as well as minimisation of energy and water waste, integrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrable Partial Differential Equations: Geometry, Asymptotics, and Numerics.' (IPaDEGAN).

assistant: **Innovation**

Partial Differential Equations (PDE's) undoubtedly are among the main tools for an efficient modelling of physical phenomena. Infinite-dimensional analogues of regular (integrable) behaviour, previously confined to the theory of systems with a finite number of degrees of freedom began to be considered in the middle of the XX century in fluid dynamics, field theory and plasma physics.   The idea that an integrable behaviour persists in non-integrable systems, together with the combination of the state-of-the-art numerical methods with front-line geometrical and analytical techniques in the theory of Hamiltonian PDE's is the leitmotiv of this research project.   Asymptotic regimes leading to phase transitions both in the theory of dispersive PDEs  and  the  theory  of  Random  Matrices display universality properties which can be analysed both numerically and analytically. The predictive power  of numerics and scientific computing can be used both as a testing tool for theoretical models and as a generator of new conjectures.By focussing the expertise of  front line researchers in different areas of Mathematics towards the study of critical phenomena in dispersive PDE's, we expect results in realms including differential and algebraic geometry, the theory of random matrices, multiscale analysis of PDE's as well as non-linear models of stratified fluid flows. The broad interdisciplinary basis and intertwining of methods of Geometry and Mathematical Physics will be instrumental in making the results accessible for the wider community. Younger (Ph.D. and/or Post-Docs) Researchers to be included in such an active and fertile research and training ground, will certainly seize their chance to enhance and broaden their skills.


**Keywords:** Integrable Systems, Random Matrices,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'KidsSurgicalPlan: An Internet enterprise for sketch-based cardiovascular pre-surgical planning' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Approximately 1 in 100 children are born with a clinically significant congenital heart defect representing 47,000 children each year in the EU. Survival of the newborn requires series of complex open-heart surgeries where optimal hemodynamic performance is essential for improved post-operative quality of life. This work proposes a new computationally-enhanced interactive system for patient-specific pre-surgical design and optimization of pediatric cardiovascular surgeries. With the proposed system, clinicians will be able to rapidly implement a contemplated intervention on a patient-specific 3D computer model without execution. A novel interface will allow clinicians to communicate their surgical intentions directly on the computer model analogous to the way they would communicate their intentions to other clinicians or bioengineers. Basic cardiovascular research on embryonic biomechanics that is being investigated in the parent ERC project will provide the essential foundation of the proposed predictive capability. This interactive framework will be deployed to the web for worldwide impact.  Based on market analysis our proposed business model becomes profitable in a short time. PoC project will provide necessary resources for developing the prototype patient-specific surgical-planning framework, clarification of regulatory pathways and follow-up pre-clinical research design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fisheries-induced adaptive changes in exploited stocks' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Today, fishing is the dominant source of mortality in most commercially exploited fish stocks. According to the United Nation's Food and Agricultural Organization, world capture fisheries have reached a ceiling, with three stocks out of four being maximally exploited or overexploited. Since all fish species were genetically adapted to the environmental conditions experienced prior to intensive exploitation, the current, drastically altered conditions cannot possibly leave their life-history patterns unaffected. In other words, fishing not only decreases the abundance of fish, but also changes their genetic composition. These evolutionary dimensions of fisheries have been overlooked for decades, so that fisheries scientists and managers are just now awakening to the formidable risks posed by further unmanaged fisheries-induced evolution.The European Research Training Network FishACE is set up to investigate the prevalence and consequences of fisheries-induced adaptive changes in exploited aquatic systems in European waters. This objective necessitates development and application of novel methodological tools for investigating empirical data, together with careful construction of theoretical models suitable for complementing empirical analyses and evaluating managerial options. At the same time, FishACE will provide advance training for a new generation of scientists that will be ready to tackle the challenges posed by evolutionary changes in exploited resources. Strategically, this Research Training Network will maintain and extend the leading position of European research in the application of evolutionary theory to exploited ecosystems.This proposal aims at a close integration of empirical and theoretical lines of development in our understanding of evolutionary proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ultra-low Power Digital circuits for Wireless Medical Implants' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Advances in nanotechnology have made it possible to implant ultra-small electronic sensors in the human body. Interfacing with organs and nervous system, these devices will be a key part of future healthcare technologies. One of the most important components in such a device is the electronic integrated circuit (IC) located right at the signal source. This determines the overall power consumption and size of an implant. However, due to the need for sensitive analog circuits and toxicity concerns, very advanced silicon technology nodes (as in consumer electronics) cannot be used in such ICs. Hence, the power & area consumption is of significant concern. The primary aim of the project is to develop custom, novel ultra-low power digital cells for efficient signal processing and communication circuits for miniature wireless medical implants. This goal fits ideally with the ongoing IMPACT project (in the same group) that aims to develop rice-grain size bio-electronic sensor to monitor cancer tumors. This project will be able to use custom digital cells to optimize this tradeoff between data compression and transmission bandwidth in such a device. The researcher will  interact with a multidisciplinary team working on the IMPACT project,  including IC designers, physicist, biochemist and clinicians. The highly interdisciplinary work will consider the limitations of such an implant in terms of its sensor functionality and physiological acceptance before deriving the electrical specifications. The researcher will bring her extensive experience in designing low-power CMOS arithmetic and memory circuits to this project. This will complement the existing knowhow in bio-sensors and high-performance sensor interfaces already being developed at the host group. She will receive trainin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Methodology and software tools oriented to KBE applications' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

There is an increasing need for industrial companies to reduce the lead times and costs for industrial products. One of the major technologies that is being used to address these needs is Knowledge Based Engineering (KBE). KBE can be described as the use of advanced software techniques to capture and re-use product and process knowledge in an integrated way, in order to reduce time and cost for engineering applications. In automating, repetitive routine design tasks while integrating multi-disciplinary expertise domains these applications can efficiently support engineering activities and dramatically reduce the cycle time. Many industrial applications are already or about to be deployed in European industry but the take-up of this technology (and obtaining the associated competitive benefits) is small. There are two main reasons for this, first is the length of time that it takes to develop KBE applications and the second is that KBE still represents a significant investment risk. Several software products are now mature enough to make KBE relatively affordable for an increasing number of companies, but a major risk is the lack of methodology and the absence of support appropriate for the full KBE application life cycle. To reduce the up-front investment in KBE, the KBE development life-cycle must be reduced and supported by a methodology, and so the following is required, - A consistent way of capturing and representing product and process knowledge; - A software tool to assist in the capture, representation and maintenance of this knowledge; - The ability to automatically generate KBE code from this software tool. To fulfil these goals, MOKA's objectives are to produce a methodology dedicated KBE and a software tool to support this methodology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Thermal and kinetic analysis of heat storage hydrates' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

It has been shown theoretically and experimentally that cooling system operated by solar energy is technically feasible. Such systems find a special interest in subtropical and equatorial regions where solar cooling could be the most widely used | application of solar energy. | Many efforts are done to get the best system allowing easy installation and low financial invests. Among the suitable systems, | those using phase change materials such as hydrated salts, with low-temperature heat. are very promising. Such materials | form an important class of heat storage substances due to their high volumetric latent storage density. We propose to study the storage behavior of such storage materials by thermal and kinetic analysis. The thermal characteristics of the hydrated salts such as CaC12/6H20, Na2S04/lOH20, Na2HP04/12H20 will be determined using calorimetric methods. The kinetic analysis will be performed by the aid of the thermogravemetric method. Training content (objective, benefit and expected impact) The installation of a recent calorimetric method may provide interesting thermophysical properties of such systems. The kinetic parameters associated with the loss of water of crystallization during heating cycles could be obtained using integrated methods. Links with industry / industrial relevance (22) he am of such a study is to determine the storage efficiency of such materials in view to their use in solar cooling systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Developing and testing a framework for the design of harmonized, context-specific Monitoring, Reporting and Verification systems for soil Carbon and greenhouse gas balances by Agricultural activities' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The EC has set the ambition to become climate neutral by 2050. As not all greenhouse gas (GHG) emissions can be avoided, such as GHGs from biological processes in agriculture, carbon removal will become increasingly important to meet the neutrality targets set. Besides carbon capture and storage by industry, carbon sequestration in the land use sector will need to compensate for the remaining emissions. In this respect, reliable yet cost-effective systems to monitor, report and verify efforts by land managers become increasingly important. This is particularly relevant for the international GHG inventory reporting, and for the development of payment systems to reward land managers for sequestering carbon and reducing GHG emissions by carbon farming (CF). The interest in CF schemes is substantial, as illustrated by the large number of (pilot) payment schemes that have been initiated in recent years. Most of the schemes are experimenting on relatively small geographical areas with a relatively small number of land managers involved. In the ‘Sustainable carbon cycles communication’  that was launched in December 2021, the EC has expressed the challenging ambition that ‘every land manager should have access to verified emission and removal data by 2028 to enable a wide uptake of CF’. MARVIC has been specifically designed to generate instruments and knowledge that enable fulfilling this ambition. The main goal of MARVIC is to develop and test a reliable Framework for the design of harmonized, context-specific MRV systems (‘MRV Framework’) for assessing carbon stock changes in soils and woody biomass and soil GHG emissions. The development of a generic MRV Framework, applicable to all agricultural land-use activities, is essential for boosting faith in public and private CF s