RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improving the organisation of maternal health service delivery, and optimising childbirth, by increasing vaginal birth after caesarean section (VBAC) through enhanced women-centred care', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Optimal, healthy pregnancy followed by normal birth is the ideal. Caesarean section (CS) doubles the risk of mortality and morbidity (hysterectomy, blood transfusion), and increases the risk of postnatal infection by 5, compared with vaginal birth (WHO Global Survey on Maternal and Perinatal Health). The European Perinatal Health Report (2008) notes “widespread concern” over rising CS rates, which vary from 15% in the Netherlands to 38% in Italy. Much of the rise is due to routine CS following previous CS, despite calls for increased vaginal birth after caesarean (VBAC), which results in less mortality and morbidity and is the preferred option for the majority of women. VBAC rates in Ireland, Germany, and Italy are significantly lower (29-36%) than those in the Netherlands, Sweden, and Finland (45-55%), a difference that equates to 160,000 unnecessary CSs per annum in Europe, at an extra direct annual cost of €156m.Using a cluster randomised trial in Ireland, Germany and Italy, with 15 clusters of 94 women, the OptiBIRTH study will attempt to increase VBAC rates from 33 to 53% through increased women-centred care and women’s involvement in their care, making savings of €2m for every 100,000 births in future. The intervention involves evidence-based education of women and clinicians, introduction of communities of practice (women and clinicians sharing knowledge), opinion leaders, audit and peer review of CSs in each site, and joint decision-making by women and clinicians.The experienced project team developed from an ESF-funded workshop “Promoting Normality in Childbirth” and a COST Action (IS0907: Creating a Dynamic EU Framework for Optimal Maternity Care), and includes 12 partners from 8 countries representing service users, midwifery, obstetrics, epidemiology, sociol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowledge-First Social Epistemology' in the context of a Horizon 2020 call.

assistant: **Objectives**

This highly ambitious project proposes a new research programme for social epistemology. Social epistemology investigates the epistemic effects of social interactions: e.g., how we gain knowledge from social sources (others’ testimony, the media), how we should respond to disagreement, how groups (scientific teams, organisations) can know. It is among the most thriving areas in contemporary philosophy. However, there is little agreement concerning the best methodological approach to social epistemological issues. Individualism puts the individual first; it asks: ‘What are the epistemic responsibilities of individuals in social settings?’ Its main weakness is that it is too demanding to be empirically plausible: according to Individualism, the individual has to do most of the work in separating reliable from unreliable sources. In contrast, Socialism puts the social factor first; it asks: ‘How does the social environment need to be for individuals to acquire justified beliefs?’ On this view, individuals need to do more or less epistemic work, depending on the social norms in force at the context. Socialism is too permissive, in that it licences socially accepted but epistemically irresponsible behaviour.KNOWLEDGELAB develops a novel methodology for social epistemology, one that puts knowledge first; it starts with the function of social epistemic interactions, i.e. that of generating knowledge. It asks: ‘How should we proceed in social epistemic interactions in order to generate knowledge?’ KNOWLEDGELAB employs this novel methodology in the service of the epistemology of testimony, disagreement and groups, and develops the first integrated account of the epistemology of mass media in the literature. This framework is highly relevant in the context of a globalized society
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REspiratory Syncytial virus Consortium in EUrope - Sofia ref.: 116019' to be submitted under Horizon 2020.

assistant: **Abstract**

RSV causes severe disease and results in substantial healthcare costs in individuals at the extremes of the age spectrum and in high risk groups. RESCEU brings together academia, national public health agencies and EFPIA with proven expertise and a strong track record in RSV research. The academic partners are leaders in RSV epidemiology, clinical RSV research, health economics, and vaccinology; and key opinion leaders with advisory roles in European and national public health bodies, health technology agencies and vaccine advisory groups. EFPIA participants (AZ, GSK, JPNV, Novavax, Pfizer, and SP) have active clinical research programmes to develop lead candidates for treatment and prevention of RSV in infants, adults and the elderly. As part of RESCEU, EFPIA participants will contribute expertise in a wide range of fields including infectious disease, clinical medicine, immunology, epidemiology, biostatistics, biomarker development, global health, and health economics. RESCEU’s aim is to develop robust evidence on RSV disease burden and economic impact; create a sustainable Europe-wide multidisciplinary, multi-stakeholder community from academia, public health, scientific societies, patient organisations, regulatory agencies and industry; and provide infrastructure to perform future pivotal trials for RSV vaccines and therapeutics. RESCEU aims to provide sustainable longer term impact on RSV disease burden and thus make a significant contribution to improved health and wellbeing in Europe.The project will comprise 6 work packages. WP 1-3 will identify and marshal data from large-scale systematic reviews of epidemiological and cost studies, disease registries, linked routine (national) healthcare and claims datasets and will establish a framework for and assemble data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Human Factors in Risk-Based Ship Design Methodology'.

assistant: **Innovation**

Up to 96% of maritime accidents (collision, grounding, fire, occupational accidents) are routinely attributed to human error. However, rather than assessing the ship performance in terms of global design factors such as ship motions and noise, the human element studies have primarily focused on local design features (e.g., bridge design) that are relatively easy to fix and tune towards required effects on the crew. From the formal point of view, the key element that has been missing and therefore preventing the integration of the human element into ship design projects is a comprehensive quantification of crew performance failure. Given the natural uncertainty of the maritime environment, such quantification must be probabilistic and therefore commensurate with safety-driven ship design methods such as the Risk-Based Design.In project FAROS, the rationalised nature of the Risk-Based Design will be used to integrate the human element into the ship safety framework and deliver ship concepts (ro-pax and tanker) that are safe, economic and “green”. This will be achieved by (1) quantitatively linking global design factors to the crew performance failure modes (fatigue, gross and fine motor skills etc.) and (2) optimising multi-disciplinary ship performance using state-of-the-art tools, methods and empirical knowledge.It is expected that the societal and personal risks on tanker and ro-pax ships can be reduced at least by 30%, provided recommended amendments to design rules are implemented and the developed ship design assessment framework, which takes into account the crew performance at sea, is used in daily ship design practice by parties relevant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Shaping time through action learning' (2014-2020).

assistant: **Innovation**

Timing permeates our daily experience. We extract temporal regularities to predict events, such as traffic light behaviour. We narrow down cause-effect relationships based on temporal proximity of events. Everyday behaviours, such as shaking hands or speaking, are possible because of accurate timing. Despite its importance, timing is an elusive concept. We lack a sensing organ for time (in the same way as we have eyes for detecting light), and there are no brain areas uniquely involved in its processing (in the same way as we have visual cortices for vision). Given these constraints, how does time perception arise in the brain? Converging evidence suggests a central role of action in enabling time perception. Developmental studies suggest that timing is ‘acquired’ as children learn to interact with the environment. Brain research indeed shows a considerable action/timing overlap, as timing computations are embedded in action control brain function. Indeed, at its core, successful behaviour is all about timing: accurate timing is what separates successful actions such as shifting gears, from unsuccessful ones such as bumping into a car in front of us. Thus, timing might emerge from our ability of learning goal-directed behaviour. We propose that the key to the time perception puzzle lies in formalizing this statement, by directly evaluating time perception in the context of goal-directed action learning. We will causally establish how learning of goal-directed action features shapes our perception and neural processing of time. This will be carried out across experiments requiring adults to simultaneously learn goal-directed actions and estimate the duration of visual stimuli, while recording electroencephalographic (EEG) measures of brain activity. This project will spe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering ubiquitin-dependent regulation of Golgi homeostasis control in neurodegeneration' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Alzheimer’s disease (AD) is the most common neurodegenerative disorder which affects 47 million patients worldwide. However, the underlying molecular mechanisms leading to sporadic-AD remain unknown and preventive treatment is not yet available. Lately, the ubiquitin-proteasome system has been implicated in AD. Dr. Merbl’s laboratory recently discovered a novel mechanism of Golgi-localized proteasomal degradation that controls Golgi integrity under stress. As the Golgi apparatus is the major hub required for protein secretion and plasma membrane localization, its proper function is crucial for maintaining cellular homeostasis and controlled cell-cell communication. This intriguing finding may be of instrumental importance to evidence of Golgi fragmentation which is observed in neurons in neurodegeneration diseases including AD as the Merbl lab identified that the ubiquitin-proteasome system is required for Golgi fragmentation.    My goal is to identify regulatory mechanisms of ubiquitin E3 ligases that are involved in Golgi fragmentation in neurons. Specifically, I aim to identify critical determinants that regulate Golgi homeostasis and integrity under changing pH and calcium concentration and decipher their role in AD using CRISPR gene manipulation, pH-dependent immunofluorescence and biochemical methods and state-of-the-art proteomic and glycomic techniques. Elucidating ubiquitin-dependent regulation of Golgi fragmentation in neurodegeneration and AD would advance our understanding not only of Golgi biology and provide new possibilities for therapeutic intervention for neurodegeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Control of cell identity in pluripotent and germline cells by OCT4 orchestration of chromatin binding and enhancer regulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The development of an organism requires the fine-tuned balance between self-renewal and differentiation of pluripotent cells. Pluripotency is controlled by a group of transcription factors (TFs) that constitute the Pluripotency Gene Regulatory Network (PGRN). OCT4 is a core component of the PGRN and is required to specify pluripotency in vivo and to maintain pluripotency in vitro in embryonic stem cells (ESCs). OCT4 is also required for survival of unipotent primordial germ cells (PGCs). However, it is still not clear how a pluripotency-associated TF like OCT4 can also be required in both ESCs and in more differentiated cells. In this proposal, I will address the hypothesis that OCT4 function in ESCs and PGCs requires the targeting of distinct cis-regulatory elements (CREs - enhancers and promoters) in the two systems. By comparing the genome-wide distribution of OCT4 in ESCs and PGCs, I will identify the OCT4-bound CREs specific for each cell type. Using bioinformatic tools, I will identify genes associated with these elements that distinguish between the transcriptional networks regulated by OCT4 in each cell type. In ESCs a decrease of OCT4 expression correlates with an increase in OCT4 binding to chromatin. To unveil the mechanisms underpinning this phenotype, I will perturb the OCT4 concentration in ESCs by combining targeted genome editing and protein degradation assays. I will extend studies of altering OCT4 concentration to PGCs using similar approaches. In addition, I will assess the hypothesis that physical interactions between CREs play a defining role in cell-specific gene expression. I will use 3D genome assays to determine whether the context-dependent function of OCT4 in ESCs and PGCs depends upon the regulation of distinct interactions between different
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bioprocess and Control Engineering for Wastewater Treatment' (BITA).

assistant: **Innovation**

The purpose of BITA is to establish and reinforce scientific collaboration  via the stimulation of research and education activities between the members of the academic groups of the network in the field of biological wastewater treatment and of its optimization by means of modeling, monitoring and process control techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Manganese rocovery from mining tailings through waste disposal'.

assistant: **Concept**

Large quantities of tailings remain in the manganese mining industry, after mining and ore dressing. They still contain substantial amounts of manganese (12 to 15%), which could not be exploited economically until now. A novel innovative and low cost method has been proposed by Prof. dr R.D. Schuiling to recover manganese by utilizing (waste) acids and sewage sludge. The innovative step in the proposed research is the mobilization by reduction that creates a method that utilizes wastes, sewage sludge (or other organic sludges) and (industrial waste) acids, in order to recover manganese from its tailings, which is not profitably possible with the present techniques. This method can be applied in situ as well as ex situ (i.e. in a reactor). After extracting the manganese from the tailings, the treated tailings can be utilized as a subsoil, and vast stretches of land (former tailings disposal area) will become available again for other uses. The process enables mining companies to consider their tailings as a secondary ore reserve instead of a waste problem. This could revive a lot of idle small scale European manganese mining companies and provides a marketable method for low cost tailings treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Solutions and Processes to Enhance the Competitiveness of Transport by Rail in Unexploited Markets', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Modern manufacturing techniques and logistics require reliable, time sensitive delivery of lower density and higher value goods. This presents a market opportunity for rail freight to grow, partly due to increasing congestion on roads, and mainly due to the need for reliable and environment friendly transport of goods. At the same time, to meet customer requirements, rail freight has to rise to the challenge of needing to be reliable and available, as well as complying with other market demands. Depending on the market segment these may be faster transport time, specialised goods systems, tracking and tracing, greater flexibility, lower prices or premium services. Furthermore in congested situations rail freight may have a competitive advantage compared to other modes of traffic.SPECTRUM will develop a railfreight train that provides a higher speed service for high value, low density and time sensitive goods with the performance characteristics of a passenger train. SPECTRUM takes a longer term, radical and first principles approach to deliver a new railfreight offering that can compete with road and air in the growing sectors of logistics where railfreight has traditionally little to offer. We shall work towards a freight train that: Behaves like a passenger train in terms of speed, acceleration, braking, momentum: allowing full scheduling on urban and sub urban train networks;Has a standardised and universal power supply system for the delivery of power to temperature controlled containers (reefers) in a controllable fashion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Strategies for the futher Improvement of Performance and Life of Lead-Acid Batteries for electric vehicle Applications'.

assistant: **Concept**

Objectives and content This Project is designed to follow, and build upon, the results achieved in Project BE 7297. While still incomplete, certain key outcomes of the research can be stated;  At the high rates of discharge experienced in EV applications, active material utilisation is limited by acid availability rather than paste conductivity. Thus there is limited scope for improvements to specific by additives to the positive active mass.  Key factors in the improvement of cycle life of the valve-regulated (maintenance-free) lead-acid battery have been shown to be, compression of the active mass by the separator, the construction of the absorptive glass mat separator and the nature of the charge regime employed to recharge the battery after use.  It has been possible to enhance considerably, the properties of the grid alloys used (strength and corrosion resistance) by additions of tin and silver. Work elsewhere has shown that rapid charging techniques, as well radically reducing recharging times, can improve cycle life of flat plate batteries apparently by modifying active material structure. Such techniques can however result in elevated temperatures in the battery, which can be detrimental to negative plate life. Also certain test regimes for EV batteries have demonstrated that the negative plate can fail under the influence of repeated and prolonged high-rate discharge pulses. Accordingly the work in the Project will focus in three areas;  The improvement of specific energy and life of leadacid batteries by the development of light-weight tubular designs using the high-strength, corrosion resistant alloys mentioned above. In this type of battery, the positive active material is constrained between the alloy spine and a porous fabric gauntlet, thus reducing opport