RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Enabling access to sound archives through integration, enrichment and retrieval'.

assistant: **Concept**

Many digital sound archives suffer from tremendous problems concerning access. Sound materials are often held separately from other materials and media, they cannot easily be listened to or browsed, and there is no way to search the content. Existing systems which attempt to deal with these issues are often library or content specific, of limited functionality, or difficult to use.Extending over two and a half years, the EASIER project will enable enhanced access to sound archives by providing multiple methods of retrieval, integration with other media archives, content enrichment and enhanced access tools. It offers methods of searching content based on audio features, musical features, or speech content. EASIER also supports cross-media retrieval, enabling access to other media besides just audio. It implements recent advances in machine learning, music and speech processing, and information retrieval. Furthermore, it addresses a growing demand for interactive electronic materials.EASIER allows archived materials to be accessed in different ways and at different levels. The system will be designed with libraries, museums, broadcast archives, and music schools and archives in mind. However, the tools may be used by anyone interested in accessing archived material; amateur or professional, regardless of the material involved. It enriches the access experience as well, since it enables the user to experiment with the materials in exciting new ways.EASIER will provide a unique, friendly interactive experience, utilizing state-of-the-art technologies to increase the effectiveness of sound archive access. The EASIER project benefits from the wealth of user needs studies in this area. This allows the work to be reactive; the tools that are developed through EASIER are in dir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Signaling of plant intracellular immune receptors' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Plant diseases are an economic, environmental and social threat affecting crop production worldwide. Effective plant disease resistance is a critical requirement to maintain world food security. Deployment of resistance (R) genes in crops is currently the most effective strategy for genetic control of disease. However, this type of resistance can be short-lived and is often affected by environmental stresses such as elevated temperature, which is highly concerning in the context of global warming.The proposed research aims to decipher the signaling function of intracellular plant immune receptors of the NOD-like receptor (NLR) family encoded by canonical and non-canonical (truncated) R genes. The opportunity at the heart of this project arises from the finding that N-terminal domains of NLRs act as potent signaling domains that are self-sufficient to activate immune responses independently of pathogen recognition and preliminary data indicate that this signaling activity is not compromised at elevated temperature (unlike full length NLRs). Hence, manipulating signaling downstream of pathogen recognition may lower the risk of resistance breakdown and provide a source of disease resistance adapted to global warming. Naturally occurring truncated NLRs lacking some of the canonical domains but containing N-terminal signaling domains are promising candidates to investigate this hypothesis. “SPLINTER” will focus on the signaling function of canonical and non-canonical NLRs in the major vegetable crop tomato, and the model plant Arabidopsis, mainly in response to the devastating phytopathogenic bacteria Ralstonia solanacearum and under temperature stress. This project will also establish a long-term research path for an early-mid career researcher returning to her home country
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The land of Caesar: Geography and economy of the imperial properties in Roman Asia Minor' (LANCRAM), addressing dissemination and exploitation.

assistant: **Impact**

The LanCRAM project aims at studying the geographical distribution and the economic, social and political impact of the properties of the Roman emperors in Asia Minor. These consisted of villas, landed estates, pastureland, woods, mines and quarries. This immense richness was a key element for the maintenance of the position of supreme power, since the emperor could use it to confer social status to individuals or to perform benefactions in favour of communities. Furthermore, imperial properties produced undeniable economic repercussions on the regions where they had a considerable extension. Since their owner was both the head of the empire and a global economic player, we can trace a tendency to trans-regional uniformity in the patterns of exploitation and a positive effect on the integration of rural areas in the political and economic system of the empire. No major survey of the available documentation has been produced since the beginning of the 20th century and many questions about the development and use of the properties remain unanswered. The project aims at filling this gap in three ways. (1) The development of a powerful online relational database of all published sources for the proposed area; every record will contain geodata and will be related to separate databases of all known persons (administrators, peasants etc.), regions and bibliographic references. (2) The preparation of a monograph on the geography and the economy of the imperial properties in Asia Minor from Augustus to Diocletian (27 BC-AD 284). This region is one of the best documented for the Roman period and offers a variety of geographical, cultural and administrative contexts that allow to study the subject from a multidisciplinary perspective; (3) the organisation of two workshops and an i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PHOTONICS QUANTUM SAMPLING MACHINE' (PHOQUSING).

assistant: **Innovation**

Randomness is a resource that enables applications such as efficient probabilistic algorithms, numerical integration, simulation, and optimization. In the last few years it was realized that quantum devices can generate probability distributions that are inaccessible with classical means. Hybrid Quantum Computational models combine classical processing with these quantum sampling machines to obtain computational advantage in some tasks. Moreover, NISQ (Noisy, Intermediate-Scale Quantum) technology may suffice to obtain this advantage in the near term, long before we can build large-scale, universal quantum computers. PHOQUSING aims to implement PHOtonic Quantum SamplING machines based on large, reconfigurable interferometers with active feedback, and state-of-the-art photon sources based both on quantum dots and parametric down-conversion. We will overview the different architectures enabling the generation of these hard-to-sample distributions using integrated photonics, optimizing the designs and studying the tolerance to errors. We will build two quantum sampling machines with different technologies, as a way to do cross-checks while exploiting all advantages of each platform. These machines will establish a new state-of-the-art in photonic reconfigurability, system complexity, and integration. Finally, we plan to perform first, proof-of-principle demonstrations of Hybrid Quantum Computation applications in optimization, machine learning, and graph theory. The PHOQUSING team includes long-term scientific collaborators who were among the first to demonstrate quantum photonic samplers; two of the leading European start-ups in the relevant quantum technologies; and theoretical experts in photonics and quantum information science. This project will help establish photoni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Automated Image Analysis Methods as an Aid for Disease Diagnosis' in the context of a Fourth Framework call.

assistant: **Objectives**

This study aims to use image analysis technology as an aid for disease diagnosis. An automated diagnostic system for disease diagnosis would speed up sample processing time and would allow for more efficient use of the time of a pathologist. An initial starting point would be to examine the detection of early breast cancer from a histological perspective. This would serve as a model which could be developed for application in other areas. There is also potential for image analysis technology to act as an aid in teaching diagnostics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dux4-Regulated Expression and Activity by an inhibitor Molecule' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Facioscapulohumeral muscular dystrophy (FSHD) is the most prevalent muscle disease that indiscriminately afflicts children and adults of all ages and both sexes. Despite several clinical trials, there continues to be no cure or therapeutic option available to FSHD patients.FSHD is caused by aberrant myogenic expression of the transcription factor double homeobox 4 (DUX4). In healthy subjects, DUX4 expression is restricted to stem cells and early stages of embryogenesis while being silenced in most tissues of the body. In FSHD, DUX4 mis-expression activates a pro-apoptotic transcriptional program leading to muscle wasting.Compelling data obtained in our laboratory identified a novel regulator of DUX4 that allows us to examine the potential of inhibiting the cytotoxic activity of DUX4 as a therapeutic strategy to treat FSHD, and represents the innovation of this proposal. The goal of the proposal is to fully elucidate the molecular mechanisms that regulate DUX4 in order to develop novel therapeutic approaches for blocking the aberrant activity of DUX4 in FSHD.Based on our preliminary data, I hypothesize that by inhibiting DUX4 we can prevent transcriptional activation of genes toxic to muscle cells.As a corollary, we propose that a drug-like molecule interfering with the DUX4 pathway could be used to prevent the toxic effects of DUX4 expression in muscle cells from FSHD patients. This work is significant as it will clarify the molecular pathogenesis of the disease and bring us closer to a rational treatment to block muscle degeneration in FSHD.


**Keywords:** Facioscapulohumeral dystrophy, FSHD, DUX4, MATR3, Muscular dystrophy, Human muscle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The plastid factory' under Fifth Framework.

assistant: **Concept**

The project will demonstrate that the higher plant plastid genome can be modified in a safe and environmentally friendly way, to enable the plastid to be developed as a factory for the production of large amounts of recombinant protein, with applications in medical, veterinary agricultural and environmental arenas. It involves refinements in the procedures for genetic modification on the plastid genome, and broadening of the crop base for which plastid transformation protocols are available to include five crops of commercial importance within the community. We expect to show that the plastid factory can play a major part in the development of oral vaccination programmes for both humans and livestock, that it can provide plants capable of removing heavy metal contaminants from soil, reduce agrochemical usage, and contribute to improved tolerance to environmental stresses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Adrenal Androgens' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The differentiation of male and female phenotype is established at 7-12 weeks post conceptionem. During this period, maintaining the appropiate intrauterine hormone environment is essential. In contrast to other species, the regulation of human sexual differentiation is linked with the development of the adrenal cortex, as can be concluded from the disorders (virilization and adrenal insufficiency in the newborn) observed in patients suffering from congenital adrenal hyperplasia (CAH), one of the most common known autosomal recessive disorders. Until now, the explanation for the corrupted sexual differentiation in CAH is mainly hypothetical and relies heavily upon extrapolation from the adult adrenocortical function. The so far widely accepted explanation upon regulation of steroidogenesis during development is based on the description of the so called classical pathway of steroidogenesis. In this pathway the conversion of 17-hydroxyprogesterone to dehydroepiandrosterone (DHEA) plays a pivotal role. Recent data of the host lab, however, indicate the existance of an alternative, previously unrecognized pathway in human androgen synthesis present in fetal and early neonatal life only, not involving DHEA. As the structure and function of the human fetal adrenal gland is unique and different from the adult human adrenal gland and rodents do not synthesize adrenal androgens at all, the studies require the analysis of human fetal tissue.The main goal of this project is to determine the expression and activity of the proposed alternative androgen pathway during normal human fetal development and its significance for sexual differentiation and disordered sex development. The proposed alternative androgen pathway may play a crucial role in the prenatal virilization of females su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hunting for the elusive “sixth” sense: navigation and magnetic sensation in a nocturnal migratory moth' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Many animals – including birds, sea turtles and insects – perform spectacular long-distance migrations across the surface of the Earth. Remarkably some, like birds, can accurately migrate between highly specific locations thousands of kilometres apart, a navigational feat that requires an external compass cue and a robust sensory system to detect it. The Earth’s magnetic field is one such compass cue. But exactly how the magnetic field is sensed, and which receptor cells are involved, remains a mystery and its discovery is one of the greatest “holy grails” in modern sensory physiology, and also the main aim of this proposal. Fortuitously, I have made a pioneering discovery that a migratory insect – the Australian Bogong moth – relies on the Earth’s magnetic field to navigate at night. Due to its tractable nervous system, this insect may thus hold the key to uncovering the identity of the enigmatic magnetosensor. By tethering flying migrating moths in a flight simulator, I will dissect for the first time how insects use magnetic cues to navigate, isolating which of the two current (contentious) hypotheses for magnetic sensation apply. The most likely of these involves the action of photoreceptor-based cryptochrome (Cry) molecules in the eyes. Having cloned genes for 4 visual opsins and 2 Cry in Bogong moths, I will use in situ hybridisation to localise putative magnetoreceptors in the eyes, targeting them with intracellular electrophysiology and magnetic stimulation in an attempt to describe the physiology of these elusive sensors for the first time. The project is ground breaking since it will elucidate how a migratory insect, despite its small eyes and brain, detects and uses the Earth’s magnetic field for navigation. The discovery of the enigmatic magnetoreceptor woul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flexible and switchable MOF-based composites for gas separation' to be submitted under Horizon Europe.

assistant: **Abstract**

Chemical separations are key processes in power plants and some industries like steel and iron manufacturing. To this end, energy-intensive thermal methods (e.g., distillation) are currently used making up the 45-55% of the overall industrial energy input. Hence, a transition from thermal to adsorbent-based gas separation is indispensable to address the EC objective to become Europe as the first climate-neutral continent by 2050. However, the low selectivity of the traditional porous materials currently used in industry (e.g., zeolites, carbons), make them unsuitable to meet this goal. Dynamic MOFs, a class of hybrid crystalline materials of recent development, show reversible framework rearrangements which may occur as a reaction to an external stimulus, make them unique for gas separation. They selectively adapt their pore structure to a specific gaseous component in a mixture, yielding exceptional selectivity, but lacking stability under industrial conditions. The project entitled DynaCOMP: Flexible and switchable MOF-based composites for gas separation aims to develop shaping strategies for dynamic MOFs towards their implementation in gas separations of industrial and environmental interest (e.g., CO2/CH4, CO2/N2, C2H2/C2H4), and to determine the impact on framework dynamicity after supporting. The project is pioneer in preparing microporous robust flexible-rigid composites of dynamic MOF thin layers supported on traditional materials, investigating their spatio-temporal phenomena. In addition, the activities described in this project will be my first steps as an independent, self-sufficient, interdisciplinar researcher; and the outcome of the overall fellowship will place me in the leading position on a new and exciting research field, with potential to tackle 21st
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of selective autophagy processes in regulating the glucose tolerance of carnivorous fish: seeking greater replacement of fishmeal by vegetal ingredients in aquafeeds' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overarching goal of MEAL fish is to further understand the role of chaperone-Mediated autophagy (CMA) and Endosomal microautophagy (eMI) in AquacuLture fish, and to determine their relative contribution to nutrient utilization and metabolism. Deciphering the role of CMA and eMI in the control of carbohydrate metabolism will contribute to shed light on diverse physiological processes that can ultimately affect fish production, including nutrition and growth. During this trainee-development focused project, the fellow, through his interactions with the supervisor and the partners (H. Wodrich, and A. Herpin, from the stellar French research institutions CNRS and INRAE, respectively), will acquire diverse state-of-the-art skills that significantly enhance his scientific and technical knowledge. The mentor (I. Seiliez, UMR1419 INRAE NuMeA) is an internationally recognized leader in autophagy, fish metabolism and genomics and provides an excellent training environment for the applicant, an experienced researcher (ER) and emerging young leader in fish biology research. It is noteworthy the novelty and originality of the project, which proposes to gain insights on the function of a recently discovered process in fish, CMA, together with the barely known eMI, and to study its applied scope in aquaculture for the promotion of the use of non-fishmeal nutrients in aquafeeds. The project focuses on an important commercial species of the European aquaculture, the rainbow trout (O. mykiss). The European research competitiveness will be continuously enhanced throughout the project by the superior training of the ER, the interaction between multidisciplinary researchers, and translating for commercial use of the derived new knowledge on the regulation of CMA and eMI and its contribu