RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An interactive protein engineering portal with validated software and database facilities' (NEWPROT), addressing dissemination and exploitation.

assistant: **Impact**

Two academic groups and eight SMEs who all work on different aspects of protein engineering will collaborate and produce a website that will consist of a portal with an embedded workbench to provide users a self-service system for in silico protein engineering. This interactive self-service portal will give users access to a wide variety of protein engineering facilities and information systems, and will allow them to interactively work with a comprehensive set of well-documented, well-integrated computational protein engineering tools. The databases that will be provided will be curated, and the software and protocols will be validated by performing a variety of protein engineering experiments on a series of enzyme classes. The portal and the interactive workbench will be freely available, and they will be solidly based in modern information technology. The usability for protein engineering will be thoroughly experimentally validated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Child immigration project' under Fourth Framework.

assistant: **Concept**

The growing presence of so-called 'second generation' and native born children of immigrants has added a significant new dimension to the already complex and difficult task of countering the inequality and social exclusion which face immigrants within the European Union. The Project proposed herein is aimed at providing a new and targeted comparative approach in order to increase inclusion and equality and, in particular, what we term 'well-being' of this component of European society. The Project examines a problematic which lies at the intersection of Area II (Research on Education and Training) and Area III (Reseach into social integration and social exclusion in Europe), and especially in the 'effectiveness of policies and actions, European dimension and diversity' (subarea II.1), the 'positive impact of European cultural diversity' (II.1.3.4), the 'cultural differences and integration of minorities' (II.1.3.5), the 'evaluation of the impact of social integration policies' (III.4) and the 'horizontal activities and development of research infrastructures' (III. 5). The Project has both conceptual objectives (to improve understanding of the various facets of the issue) and practical objectives (to search for solutions to ameliorate the problem). The work will thus consist in: 1. development of a fundamental terminology for research on children of immigrant origin in European countries and a characterization of the forms and models of cultural diversity and of social inclusion and integration of children of immigrant origin which define the current phenomena; 2. comparation of:  a) knowledge on concepts, methods, values and policies;  b) alternative schemes of education and family support,  c) indicators for measuring policy impact in terms of equality, inclusion and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evaluation of MHC genes as quantitative trait loci for disease resistance in fish.' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The objective of this study is to assess the usefulness of highly polymorphic genetic markers, the Major Histocompatibility Complex (MHC) genes, of which it has been firmly established that the molecules they encode are critically involved in the initiation of an adequate immune response to pathogens, as quantities trait loci (QTL) for improving selective breeding.The Major Histocompatibility Complex surface glycoproteins play an important role in the immune defence of higher vertebrates where they bind and present endogenous (MHC class I molecules) and exogenous (MHC class II molecules) peptides to T cells, thereby triggering a specific immune reaction towards the pathogen, from which the peptides are derived. The exogenous peptides bound by the MHC class II alpha/ MHC class II beta molecule are mainly derived from bacteria, whereas the endogenous peptides bound and presented by the MHC class I molecule are derived from intracellular virus or self proteins. The MHC class I and class II beta genes are highly variable, i.e., there are numerous alleles and numerous haplotypes in a population. Each allele has the ability to bind and present different groups of peptides in more or less successful ways. Thus, the response of an organism towards certain pathogens can be genetically influenced by the MHC haplotype.  The best documented MHC correlation with disease resistance is that in chicken with respect to Marek's disease where they were able to use a large number of experimental animals. Fish is another example of an animal species where large numbers of offspring can be generated, and used in appropriate challenge or selection programs. Several studies have shown that the MHC is indeed highly polymorphic in fish. Moreover, the number of expressed MHC genes of both classes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The development of a yarn management system for tufting machines in carpet production' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Tufting is the process of pushing pile yarns or strips of ray through a coarsely woven or non-woven backing cloth. The state of art is that the yarn supply c.q. the yam tension is not controllable and varies greatly during tufting. This varying yarn tension has a great impact on the tufting process and the final product. The total economic burden due to the loss of productivity, the waste of raw materials, and the loss of quality is estimated at about 250 MECU each year in Europe. The objective is the development of a reliable and self-controllable yarn management system for tufting machines, comprising of a system of yarn tension controllers for individual yarns, low and high yarn tension alarm sensors and an advanced control system. The advantages of the yarn management system are: 5 % productivity increase, 5% preservation of raw materials, improved quality and 40 - 50 % waste reduction. A prototype yarn management systems will be built which will provide the data for the design of commercial for both existing and newly-designed tufting machines. The Consortium consists of developers and end-users (carpet manufacturers) of the yarn management system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ZEOlites for the conversion of CO2 to fuels and chemicals' (ZEOCO2) targeting Horizon 2020.

assistant: **Abstract**

ZEOCO2 is a pioneering and structured effort to comprehensively study the introduction of well-positioned Zn, Cu and acidic catalytic active sites in zeolites to directly convert CO2 into fuels and chemicals in one step. This offers step economy due to the possibility of coupling the hydrogenation of CO2 with further C-C coupling within the same heterogeneous catalyst. The synthesis of cheap, stable and active zeolites with Zn sites incorporated in the framework generates Lewis acid sites and favours the positioning of Cu sites by ion-exchange. These Cu sites will deliver redox activity, while Al and Zn will yield acid sites, both needed in the tandem catalytic system. So far, the use of such bifunctional zeolites and especially core-shell structures have not been explored for the tandem process involving the consumption of CO2 and synthesis of gasoline or light olefines. Using a two-stage research methodology, ZEOCO2 will not only provide new hybrid zeolite synthesis technology to be used in acid and redox type processes, but also demonstrate the first direct CO2 to fuels/chemicals conversion within one solid catalyst.The combined expertise of the fellow and the host ensures the best chance for successfully completing the ZEOCO2 objectives in a mutually beneficial manner. On the one side, internal collaborations will allow access to state-of-the-art synthesis laboratories and train the researcher in catalysis engineering using gas-phase reactors in continuous mode; needed to prepare and test the novel zeolite catalysts. On the other hand, a secondment in a world-leading spectroscopy (applied to catalysis) research team, will allow to get new insights into the molecular nature of the active sites and provide understanding of the reaction mechanism and deactivation pathw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The potential of oligonucleotide submicrob positively charged, emulsion ocular delivery system for age related macular degeneration' (1998-2002).

assistant: **Innovation**

Navigable wants to investigate co-operation possibilities between two well-reputed research institutes and some European Sums to form a consortium for the research development and marketing of a remedy to treat ARMD. Age-related Macular Degeneration, a common eye disorder, the leading cause of severe vision loss in people older than 50 years. The wet form is the most severe type of macular degeneration notwithstanding it affects only 10% of those with the diseases it accounts for 90% of the blindness caused by ARMD.Today about 400,000 new cases of wet ARMD occur each year in the USA and Europe. Products existing today can treat only 15% of the patients with this form. Navigable wants, on basis of its oligonucleotide and Ribosome submicronpositively charged emulsion delivery system, to form the above alliance to bring the fruit of the cooperation as a remedy to the market which will result in dramatically increase of the treatment of wet ARMD and thus enormously reducing this cause of blindness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of de novo evolution in the emergence of new genes' under Seventh Framework.

assistant: **Concept**

Gene evolution has long been thought to be driven primarily by duplication or transposition mechanisms, followed by divergence of the duplicated copy. However, every evolutionary lineage harbours also so-called orphan genes, which have no homologues in other evolutionary lineages i.e. which do not appear to have arisen via gene duplication mechanisms, or have diverged to a point where their origins can not be traced anymore.  Orphan genes are generally thought to be important drivers of taxon specific adaptations and interactions with the environment. New insights from comparative genomics and phylogenetic analysis suggests now that orphan genes could indeed be created through de novo evolution and it is becoming increasingly clear that this mechanism might occur at high rates, which would provide a continuous source of material for new gene functions. However, only initial evidence is available for this so far and little is known about the evolutionary dynamics and mechanisms of de novo gene emergence. The present proposal will use experimental and functional approaches to study the role and the evolutionary potential of the emergence of completely new genes from random sequences. This will open up new perspectives in understanding the evolution of genomes and the molecular mechanisms of adaptation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable Asymmetric Catalysis with Iron', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal addresses a clearly urgent need to develop novel homogeneous catalysts for the asymmetric hydrogenation of ketones with hydrogen gas, as a green, energy- and cost-efficient alternative to the currently used protocols. Instead of precious metals, we attempt to utilize transition metal complexes based on environmentally benign, inexpensive and non-toxic iron. First examples in the asymmetric hydrogenation using iron complexes are a promising indication that efficient systems might in principle become viable with further catalyst development and by careful selection of ligands and reaction conditions. Based on an extensive initial catalyst screening, well-defined complexes of two different classes will be designed and synthetized: 1) Complexes of general formula [Fe(P-P)(N-N)X2], which feature two bidentate ligands structurally related to the known PNNP tetradentate systems; 2) Piano-stool Fe complexes containing pendant H-donor groups as well as strongly electron-donating chiral carbene ligands. Recognizing and addressing the expected challenges, mainly related to transitioning from precious metals such as ruthenium or rhodium to a first row alternative will largely contribute to the basic scientific knowledge in this field.The most promising catalysts will be subsequently applied in the transformation of biomass-derived ketones originating from the oxidative disassembly of lignin, therefore this proposal offers various multidisciplinary aspects while relying on solid background in classical asymmetric catalysis.  In case of success this research will contribute to the transition towards a sustainable society in multiple ways.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DEMONSTRATION PROJECT INDUSTRIAL PARK BERLIN-TEGEL, 3,5MW (TH) FLUIDISED BED COMBUSTION FOR HEAT GENERATION' under Fourth Framework.

assistant: **Concept**

In the framework of the project a bubbling FBC (Fluidised Bed Combustion) with an output of 3,5 MWth for the combustion of biomass and waste is proposed. Comprehensive preliminary tests carried out at the University of Magdeburg have revealed that biomass, also mixed with other fuels, can be efficiently incinerated by fluidised bed combustion.Large scale coal fired FBC cogeneration plants have been operated successfully for a number of years. Small scale plants are less widely spread and none have yet been laid out for biomass combustion in the EU.Adapting FBC to bio-fuels is characterised by the high content of volatile matters. This task will have to be solved with respect to well-balanced heat in the bed by simultaneously keeping to all emissions regulations. This task shall be demonstrated by realising the proposed plant at high technical standard.The plant will then serve as reference for further biomass FBC plants.The final economic evaluations showed that the plant could not be operated cost - effectively on this site in the medium-run. The consumer structure and thus the heat demand has changed drastically since initial planning of the plant. It has become impossible to obtain the required number of full - load operating hours in order for the plant to be economically viable. Thus a decision had to made on modifying the project.It is possible to transfer the project to a site about 5 km away. Here the economic conditions are far better as components of an existing plants can be use and a steam turbine for power generation exists. the CFB-boiler can generate ca. 66000 MWhth/y enabling ca. 10000 MWhel/y electricity to be generated.Presently a new technical description is being drawn-up as basis for annex 1 to the existing EU contract.On approval of the Commission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Three Indirect Probes of Lyman continuum LEakage from galaxies' (TRIPLE), addressing dissemination and exploitation.

assistant: **Impact**

Cosmic reionization corresponds to the period in the history of the Universe during which the predominantly neutral intergalactic medium was ionised by the emergence of the first luminous sources.  Young stars in primeval galaxies may be the sources of reionization, if the ionising radiation, called Lyman continuum (LyC), that they produce can escape their interstellar medium: the escape fraction of LyC photons from galaxies is one of the main unknowns of reionization studies. This ERC project will contribute to answer this question, by computing from simulated galaxies three indirect diagnostics of LyC leakage that were recently reported in the literature, and comparing the virtual observables with the direct escape of LyC photons from simulated galaxies, and with observations. The first diagnostic for LyC leakage relates the escape of the strongly resonant Lyman-alpha radiation from galaxies to the LyC escape. It was proposed by the PI (Verhamme et al. 2015), and recently validated by observations (Verhamme et al. 2016). The second diagnostic proposes that the strength of Oxygen lines ratios can trace density-bounded interstellar regions. It was the selection criterion for the successful detection of 5 strong Lyman Continuum Emitters from our team (Izotov 2016a,b). The third diagnostic relates the metallic absorption line strengths to the porosity of the absorbing interstellar gas in front of the stars. The increasing opacity of the intergalactic medium with redshift renders direct LyC detections impossible during reionisation. Indirect methods are the only probes of LyC leakage in the distant Universe, and the proposed diagnostics will soon become observables at the redshifts of interest with JWST. They have passed the validation tests, it is now urgent to calibrate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regularity and Stability in Partial Differential Equations' (RSPDE) under Horizon 2020.

assistant: **Objectives**

This project focuses on several problems in Partial Differential Equations (PDEs) and the Calculus of Variations. These include:- Optimal transport and Monge-Ampère equations.In the last 30 years, the optimal transport problem has been found to be useful to several areasof mathematics. In particular, this problem is related to Monge-Ampère type equations, and understanding the regularity properties of solutions to such equations is an important question with applications to several other fields.- Stability in functional and geometric inequalities.Whether a minimizer of some inequality is ""stable'' in some suitable senseis an important issue in order to understand and/or predict the evolution in time of a physical phenomenon.For instance, quantitative stability results allow one to quantify the rate of convergence of a physical system to some steady state, and they can also be used to understand how much the system changes under the influence of exterior factors.- Di Perna-Lions theory and PDEs.The study of transport equations with rough coefficients is a very active research area. In particular, recent developments have been used to obtain new results on the semiclassical limit for the Schr\""odinger equation and on the Lagrangian structure of transport equations with singular vector-fields (for instance, the Vlasov-Poisson equation). These problems, although apparently different, are actually deeply interconnected.The PI aims to use his expertise in partial differential equations and geometric measure theory to introduce ideas and techniques that will lead to new groundbreaking results.""