RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Imaging Biomolecular Self-Assembly with a Molecular Photonic Scale'.

assistant: **Concept**

We propose to transform our understanding of biomolecular interactions and self-assembly by directly visualising the associated molecular mechanisms. To achieve this, we will capitalise on our recent development of interferometric scattering mass spectrometry (iSCAMS), which enables not only the detection and imaging of single biomolecules in solution, but also the accurate determination of their molecular mass at the single molecule level. These studies, and the development of the associated technology, will bridge the gap between high-resolution structural and low-resolution solution-based methods for studies of biomolecular interactions and assembly. We will achieve these ambitious goals by pursuing five interconnected objectives chosen according to their potential to maximise scientific and societal impact by addressing fundamental questions related to biological function and health: (1) Determine the physicochemical origins of mono- and polydispersity; (2) Visualise the mechanism of viral capsid assembly; (3) Reveal the molecular basis of cytoskeletal dynamics; (4) Capture the aggregation and inhibition of amyloid aggregation. These four system-oriented objectives will be accompanied by a technological objective, (5) aimed at implementing improvements in terms of dynamic range and resolution of iSCAMS required for studying self-assembly. As a consequence of the universal applicability of our approach for characterising molecular interactions, oligomeric distributions and dynamics in a facile fashion in solution, this ambitious project opens up a broad range of exciting applications beyond molecular biophysics in fields as drug-discovery, bioanalytical and biomedical science.


**Keywords:** Biophysical Chemistry, Label-free imaging and sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of smart polymer surfaces' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The overall objective of the project is to increase the knowledge and research level of the Institute of Textiles at the University of Maribor, on the creation of tailored and/or smart fibre forming polymers and materials that would be able to control the realise of various active compounds, or to create tailored fibre surface properties for different end-applications in the area of technical textiles, such as medical, therapeutic, hygienic and protective textiles.The project will transfer the knowledge of technologies based on- colloidal micro-hydro-gelation,- nano-micro-(en)capsulation and- polymer surface coating,- innovative biotechnological, green-chemistry and chemical catalysis tools, or their combination, will be applied to activate and/or modify polymer surfaces and/or colloidal particles/layers created by ecologically and toxicologically suitable processes.According to the diversity of the knowledge and expertise that shall be transferred, the project will build a highly multidisciplinary scientific group, cutting across different established research areas, i.e. textile chemists, physical chemists, biological catalysts and colloidal engineers, that will be able to prepare colloidal particles, coatings and multilayers, and subsequently apply them to different suitably pre-activated and/or modified natural and synthetic polymer surfaces. The new fibre materials with upgraded properties can be exploited either to enhance the bulk properties of existing products for better performance, or to create new value-added products with smart and/or tailored surface characteristics based on the multifunctionality.The project will increase the host research quality and overall RTD capability related to the EU competitiveness as well as contributes to the strengthening of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Strengthening and Upholding the Performances of the new Engineered Research PANELS'.

assistant: **Innovation**

A great effort has been spent in the mechanical engineering fields in order to conceive new panels of improved static and dynamic performances. This was due to the search of innovative design solutions specifically tailored for facing with the problem of transportation engineering where the vehicle requires high stiffness, low weight, low noise, low cost design. The project will allow the co-operation amongfive different research groups of different sizes but all active at international scale, in the automotive, aerospace, naval, and railway transportation. The process of exchanging researchers and coordinating activities will allow maximising the specific expertise of each group, and aiming also to a faster selection and developments of the candidate panels, configuration and materials. In fact, the range of such panels is now very large according also to the possibility offered by new technologies, but these last are still to be deeply investigated in order to explore their capabilities. Further, on the researcher shelf there are innovative methods that only a decade ago were at an initial stage; in fact, the increase of the knowledge about standard predictive structural and structural-acoustic tools has been impressive and in the near future some of the methods now used at research level will enter in the common engineering practice. In this project they will be extensively used, tested and verified against the specific measurements that will be needed to verify the predicted and expected performances. Several candidate solutions will be suggested and motivated at the beginning of the project, so defining a sort of current design. The results will qualify how and where the specific performances have been increased without penalties for any other standard requirements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PrDx - Advanced Software for Predicting the Immune Response During Drug Development' (ImmuniPrDx), addressing dissemination and exploitation.

assistant: **Impact**

>90% of drug and vaccine candidates fail during drug development, resulting in an average of €35M lost per drug for the pharma companies, and a slow and expensive drug development process. A major reason for failure is unwanted/lack of immune response of the drug/vaccine candidate. Thus, immunogenicity prediction tools, Epitope Prediction Software (EIPS) and assays, are important for cost-effective and safe drug development. However, available EIPS are over-predictive and limited: using the current gold standard EIPS netMHC, <10% of the predicted immunogenic epitopes induce an immune response. Immunitrack has developed a next generation EIPS - PrDx - that with high accuracy and no false positives far exceeds the performance of netMHC. PrDx, to be applied alone or in combination with our successfully commercialized immunogenicity assays, is a strong tool for streamlining drug and vaccine development, meeting user needs for multiple applications: i) identify immunogenic epitopes to be included in a vaccine; ii) identify unwanted immunogenic properties of a newly developed drug, and iii) guide treatment by assessing patient immune response. For commercialisation, PrDx must be shaped into a customer friendly format and meet regulatory demands; the goal of the Innovation project is to conduct activities related to certifications and requirements, and user tests for demonstration and validation, critical for PrDx awareness and knowledge of user benefits. Immunitrack will sell PrDx reports for drug/vaccine candidate immunogenicity screening and complementing immunogenicity assays, through direct and indirect sales with a predicted accumulated turnover of €56M 5 years post commercialization. Immunitrack has unique capacities confirmed by our 90 customers within PrDx’s target gr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Algorithms and complexity in information technology' (1994-1998).

assistant: **Innovation**

The main objective of the ALCOM-IT project is to develop technologies and methods for the design of efficient algorithms, and to transfer them to the industrial domain. In particular, we plan to:- Deliver correct, efficient, and easy-to-use libraries of combinatorial software of general applicability and embodying the best algorithms and data structures;- Provide solutions to efficiency-critical algorithmic and optimisation problems arising in particular IT application domains, e.g., management of large computer and communication networks, advanced graphical software engineering environments, logistics, and resource management;- Transfer to application developers, in industry and elsewhere, new paradigms, methodologies, tools for algorithm design and analysis, and best-practice criteria;- Develop new algorithms and new methods for their analysis and design, and improve the understanding of efficient computing.As our past experience shows, libraries can be used as a basis of fast and cost-effective industrial software development. Furthermore, providing efficient solutions to more specialised tasks will produce results of immediate applicability for industrial users. We believe that our work reacts to the industrial needs arising in the strategic domains of Software Technologies (e.g., the need of libraries and graph drawing tools in software systems), High Performance Computing and Networking (e.g., efficient solutions for the management of communication networks), and Integration in Manufacturing (e.g., the development of frameworks for logistics and resource management).Our objective of providing high-quality software that meets the standards of front-line algorithmic research will be met by having fundamental research and software development tightly coupled (in our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Design, synthesis and evaluation of highly stereoselective chiral selectors to be used for enantiomer separations by membrane methodologies'.

assistant: **Objectives**

Research objectives and content The objective of the present proposal is the development of new Liquid Supported Membranes (LSM) from chiral selectors of high lipophilicity. These molecules should be designed by molecular modeling, tested with different techniques, and modified, if necessary, in basis to their chiral recognition ability to obtain high selectivity factors for the separation of enantiomers. Later, they would be highly lipophilised to be used as 'chiral additives' in LSM technology. The resulting chiral membranes would be optimized, in order to maximize its performance, stability and producibility rates, and used for preparative enantioseparations. Training content (objective, benefit and expected impact) The project would add to the actual experience of the applicant the knowledge and training in several technical and scientific disciplines such as molecular modeling, new synthetic procedures and, obviously, membrane technology. All these elements ensure a broad training programme that would be of an important impact either for the European industry, due to the potential applications of the membranes envisaged, and for the applicant, due to the quality of the scientific research to be developed. Links with industry / industrial relevance (22) The host institution is cooperating with pharmaceutical industry in this project that has the granted Brite Euram EU Project on Chiral Membranes. The research results would be of industrial relevance, because chiral membranes should be highly interesting tools for the separation of enantiomers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nuclear European Platform of Training and University Organisations (NEPTUNO)' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The aim is to better integrate European education and training in nuclear engineering and safety to combat the decline in both student numbers and teaching establishments, thus providing the necessary competence and expertise for the continued safe use of nuclear energy and other uses of radiation in industry and medicine. The project focuses on a harmonised approach for education and training in nuclear engineering in Europe and its implementation, including the better integration of national resources and capabilities. The expected result is a operational network for training and life-long learning schemes as well as on academic education at the master, doctoral and post-doctoral level, underpinning:... sustainability of Europe's excellence in nuclear technology... harmonised approaches to safety and best practices, both operational and regulatory, at European level in Member States and Accession Countries... preservation of competence and expertise for the continued safe use of nuclear energy and other uses of radiation in industry and medicine... harmonised approach for training and education in nuclear engineering. In the network... we implement the roadmap for nuclear education in Europe as developed and demonstrated in the ongoing Euratom FP5 project ENEN... we warrant the end-user relevance of the training and education by involving corporate organisations e.g. Pan-European Nuclear Training Centres Association, by recruiting (part-time) professors out of industry and by providing (re)training of nuclear industry personnel... we teach advanced courses preferably at selected centres of excellence bridging leading edge research and new knowledge generation with teaching and education creating nuclei of excellence for doctoral schools in nuclear engineering and scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spatially rEsolved Single-cell Approaches in Haematologic MalignanciEs' (SESAHME), addressing dissemination and exploitation.

assistant: **Impact**

A global understanding of therapy response and therapy resistance in haematologic malignancies, including multiple myeloma and acute lymphoblastic leukaemia, in which cancerous cells accumulate in the bone marrow, is still lacking. This is due to the complex nature of the bone marrow. Therefore, the goal of SESAHME is to determine the difference of the bone marrow microenvironment in healthy individuals and patients suffering from multiple myeloma and acute lymphoblastic leukaemia. This will help to understand under which conditions cancerous cells can accumulate and proliferate in the bone marrow which could lead to advanced immunotherapy approaches in the future.To achieve this, the objectives of SESAHME are to 1) establish a method that allows to determine the immune microenvironment composition in human formalin-fixed paraffin-embedded samples of the bone marrow, which has the potential for high-throughput screening and being cost effective at the same time; and 2) to use this method to characterise a healthy and dysfunctional bone marrow microenvironment that can contribute to multiple myeloma/acute lymphoblastic leukaemia development and progression.SESAHME will allow the fellow to independently carry out a project which will set the ground to build upon an own, individual research profile to eventually become an independent researcher. Key transferable training will further improve the employability and career prospects of the fellow, as well as increase the fellow’s communication abilities. The host offers a multi-disciplinary environment that is well connected with experts in the field enabling the fellow to develop a new mindset and approaches. The fellow brings international and specialised wet-lab experience that will facilitate knowledge exchange and increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SHIFTting the narrative of the climate GENeration: ecology, emotions, and critical thinking in young adult contemporary climate fiction' in the context of a Horizon Europe call.

assistant: **Objectives**

SHIFT-GEN investigates how narratives of climate change can affect young generations, proposing the first extensive study of young adult climate fiction (YA cli-fi) in English (2000-2023; interest age: 13-19 years). Emerging studies reveal that the chronic fear of environmental catastrophe is particularly affecting young people’s daily life. Feelings of climate anxiety and ecogrief are amplified by a sense of intergenerational injustice, with the so-called climate generation often portrayed as an innocent victim that adults are failing to protect. By adopting an ecocritical perspective, my research will examine whether YA cli-fi portrays young adults as assertive leaders and protagonists, shaping their own future. Moreover, combining recent developments in ecocriticism - namely econarratology, affective ecocriticism, and empirical ecocriticism - this project will investigate whether YA cli-fi is able to prompt the development of ecological citizenship, communicate fears and hopes about the future, and inspire creative thinking and long-term action. Given its scope and purpose, the proposed research is a timely contribution to current ecological debates and can offer significant insights on the connection between the health of people, animals, and ecosystems, engaging in a One Health approach. This three-year action will be undertaken under the supervision of Prof. R. Baccolini (UNIBO) and Prof. E. James (UIDAHO), and includes a secondment supervised by Prof. M. Caracciolo (UGENT). It will comprise a transversal training and the acquisition of transferable skills, as well as a targeted program of dissemination and communication activities. The project will also undertake citizen science research engaging with university students of the Emilia-Romagna region to explore th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Personalised Quantitative Upper Extremity Assessment for Stroke Rehabilitation' (Rehab-Assessment).

assistant: **Concept**

Globally, 15 million people suffer a stroke every year, causing 6 million deaths and leaving another 5 million permanently disabled, which makes stroke the second leading cause of disability.  In the Europe, it is the most common cause of morbidity and long-term disability, and has significant socioeconomic consequences for patients, their partners and society. Thus far, upper limb weakness remains the biggest and most challenging disability, due to the complexity of movement required in daily living and its generally slower and less complete recovery. More than 50% of stroke survivors still have upper extremity hemiparesis one year after stroke. Neuro rehabilitation is the main approach to improve upper extremity motor outcome, and previous studies have demonstrated that patients can regain considerable motor functions after intensive training. With the number of people surviving a stroke soaring, more and more rehabilitation programs are delivered with minimal involvement of a physiotherapist due to limited resource available, and the success of this approach depends on the accurate assessment of stroke patients’ movement impairment.  In collaboration with with the National Demonstration Centre in Rehabilitation Medicine, Leeds Teaching Hospitals NHS Trust, my vision is therefore to establish a comprehensive, quantitative, objective and personalised Motor Impairment Index (MII), via benchmarking the impaired arm movement to healthy arm mirrored exercise to quantify the motor impairment. This approach will increase the likelihood of successful rehabilitation leading to improved quality of life for millions of people affected by stroke. This application focuses on developing innovative healthcare technologies for stroke patients; but it could also potentially benefit mi