RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sorption of urea herbicides to black carbon'.

assistant: **Objectives**

Pyrogenic carbon particles (collectively termed black carbon; BC) are ubiquitously present in sediments and soils and appear to explain fractions of strongly sorbed hydrophobic organic contaminants, thus having implications for the fate, availability and toxicity of these compounds.In common for compound groups exhibiting strong sorption to BC is their (capability of attaining a) planar conformation (e.g., polycyclic aromatic hydrocarbons; PAHs).Strong adsorption to combustion residues is not yet included in the current scientific picture of how pesticides distribute in the environment, although the molecular structure of many pesticides indicates the potential for a high affinity to BC.The overarching objective of the proposed study (SUREAL) is to better understand pesticide sequestration and availability in soils and sediments.The scientific objectives are- to study the mechanism behind BC sorption for phenyl ureas,- to investigate competition between PAHs and phenyl ureas, and- to study the in -field relevance of BC sorption for phenyl ureas.Phenyl ureas were selected as model pesticides, because- strong sorption to burned crop residues was reported,- of their largely planar conformation,- they are commonly used in Europe, and- they were frequently detected in the aqueous environment.Laboratory sorption experiments will be conducted with BC and carefully selected soils and sediments representing different organic matter characteristics, BC and PAH content. SUREAL, contributing to a refined and improved risk assessment of pesticides in the environment, refers in several ways to the European research areas as specified for the sixth framework programme.More specifically, it relates to the European water framework directive, of which one of the main goals is to achieve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CERN Schools of Computing for the LHC Computing Grid' (CSC-LCG), addressing dissemination and exploitation.

assistant: **Impact**

This proposal concerns a series of four annual schools as part of the CSC (CERN Schools of Computing) programme, covering the period 2004-2007. CSCs are two-week schools, attended by up to 80 students, taking place in one of CERN's Member States, leading t o an optional examination and certificate of proficiency, comprising lecture series and practical work (project-oriented). The proposed series will focus on the computing technologies needed for the LHC, CERN's new accelerator to be put in operation in 200 7. One of the biggest challenges that the LHC is facing is to build a global computing environment, the LHC Computing Grid (LCG), to meet requirements far beyond any past demand: 11 petabytes of data to be recorded per year, a hundred thousand of today's f astest processors. Technologies specifically relevant to the LHC Computing Grid, to be covered during the series will include: ? Grid middleware: Virtual Organization (VO) management; data management; resource location and brokering; security including PKI s, authentication, authorization; system monitoring and error handling. ? Very-large scale computing: large-scale mass storage (incl. management of high-capacity disk/tape systems); high-end compute farms for intensive data processing; very-high bit-rate n etworks. ? Software management for large-scale distributed projects Key distinguishing feature: Novel technologies such as Grid middleware are rarely taught from a practical angle. The yearly program will adjust to the progress of the LCG, taking into acco unt actual results and lessons learnt from the phased implementation. Training will be practical, not purely theoretical, will match the reality and reflect problems encountered. Strategic importance: It is admitted that Grid technologies will permeate the s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional Analysis of Schizophrenia Risk Gene RBM12' (SZFunc), addressing dissemination and exploitation.

assistant: **Impact**

Schizophrenia is a devastating disease with high societal costs. However, little is known about the biological mechanisms behind the disorder, a knowledge gap that has stalled the development of new treatments. We recently discovered that truncating mutations in RBM12, an RNA binding protein, are associated with schizophrenia. This finding provides a novel entry point to understanding the disease, but fully exploiting the discovery requires further examination of the function of RBM12. Here I propose to begin that effort by using the zebrafish model system to first, determine the role of RBM12 in brain development; second, discover the role of RBM12 in brain function as assessed by functional connectivity and behavioural assays; and third, identify RBM12’s direct and indirect targets using RNA-seq and iCLIP (individual-nucleotide resolution cross-linking and immunoprecipitation). These studies will aid in illuminating the biological basis of schizophrenia and, ultimately, lead to novel treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European Regulatory Science on Tobacco:Policy implementation to reduce lung diseases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Smoking and other forms of tobacco consumption are considered the single most important cause of preventable morbidity and premature mortality worldwide. Efforts to reduce the devastation of tobacco-related deaths and illness in the EU consist of the Tobacco Products Directive (TPD), and the ongoing implementation of the WHO Framework Convention on Tobacco Control (FCTC). The main objective of EUREST-PLUS is to monitor and evaluate the impact of the TPD within the context of FCTC ratification at an EU level. Our 4 specific objectives hence are: 1) To evaluate the psychosocial and behavioral impact of TPD implementation and FCTC implementation, through the creation of a longitudinal cohort of adult smokers in 6 EU MS (Germany, Greece, Hungary, Poland, Romania, Spain; total n=6000) in a pre- vs. post-TPD study design. 2) To assess support for TPD implementation through secondary dataset analyses of the Special Eurobarometer on Tobacco Surveys (SETS), cross-sectional surveys performed among 27,000 adults in all 28 EU MS, before the TPD is implemented and to monitor progress in FCTC implementation in the EU over the past years through trend analyses on the merged datasets of the 2009, 2012 and 2015 SETS datasets (n=80,000). 3) To document changes in e-cigarette product parameters (technical design, labelling/packaging and chemical composition) following implementation of Article 20 of the TPD. 4) To enhance innovative joint research collaborations, through the pooling and comparisons across both other EU countries of the ITC Project (UK, NL, FR), and other non-EU countries . Tackling tobacco use is quintessential to reducing the impact of chronic NCDs, a topic EUREST-PLUS will stride to lead.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Society and Lifestyles: Towards Enhancing Social Harmonization through Knowledge of Subcultural Communities' (SAL).

assistant: **Concept**

The overall project aim is to extend knowledge about values and religions in Europe by the investigation of communities representing various values and religious beliefs in New Member States.The strategic objectives of this proposal are toa) assess the degree of subgroup differentiation in the post communist societies,b) to study how the differentiation process is proceeding,c) to investigate the degree to which the subgroup structures and processes vary in several post-communist societies,d) to compare both the subgroup structure and the processes in the post-communist societies to those seen in western Europe.How groups arise, function, and disappear is of interest both in theory and in practice. The scientific interest arises because the matter is topical in the social sciences (e.g. anthropology, sociology), and also because the dynamics of groups is clearly non-linear and recent advances in computational tools make the study of such processes finally possible. These topics are of great practical concern and applicability because they impact such crucial issues as social cohesion, inter-group tensions, discord, and violence.Project will use advantages of interdisciplinary approach, based on the methodology of cultural/social/political anthropology. This will be implemented through fieldwork emphasising an in-depth integration of researchers into the groups under analysis with the purpose of revealing the meanings of the real life as well as understanding the meanings of values and religions, deriving from these groups and spread into the society-at-large. For evaluation of research results and recommendations novel approach of field-testing will be used when possibilities effectively exploit recommendations of the project in real field conditions with participation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SUtainable and REsilient solutions for SOIL erosion control and sediment management'.

assistant: **Concept**

Soil erosion is a growing concern, with vast areas of soil lost every few seconds, posing serious risks to food security, biodiversity, and climate resilience. It not only undermines soil fertility but also causes environmental and economic damage, affecting over 60% of European soils. The erosion of soil also leads to significant sedimentation in rivers, lakes, and coastal regions, clogging waterways, damaging aquatic habitats, and disrupting essential infrastructure such as reservoirs and irrigation systems. These sediment loads further exacerbate water pollution, triggering ecological problems like eutrophication. This issue is compounded by increasingly extreme weather events, such as floods, droughts, and wildfires, impacting not only Europe but also countries like Thailand, Japan and China. In response, the EU has introduced initiatives like the European Green Deal and the Soil Strategy for 2030 to safeguard soil and sediment resources while promoting sustainable development. However, the complexities of soil erosion and sedimentation—further intensified by climate extremes—make monitoring and management challenging. The SURE-SOIL project addresses these challenges through a collaborative effort, bringing together academic institutions and SMEs from across Europe and beyond, including Thailand, China, and Japan. By combining expertise in geosciences, civil engineering, environmental science, and data analytics, SURE-SOIL aims to develop innovative, practical solutions for managing soil erosion and sedimentation. This collaborative approach will not only advance scientific research but also support the implementation of sustainable, adaptable strategies in various global contexts. Through shared knowledge, international partnerships, and cutting-edge technologies,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'I have seen that before: Pattern completion in the human visual system and its role for memory' to be submitted under Horizon 2020.

assistant: **Abstract**

The visual system is an anticipatory system. For example, in order to hit a tennis ball during a match, parts of the brain calculate the future trajectory of the tennis ball based on its past travel through the air to enable you to hit the ball. A recent study by Ekman et al. (2017) demonstrated how the visual system anticipates a ball’s trajectory in such a scenario. In their functional magnetic resonance imaging (fMRI) study, they found temporally compressed pattern completion in primary visual cortex for a previously learned rapid stimulus sequence (simulating a moving dot) following the presentation of only the very first stimulus. This visual preplay activity reflects an anticipation of the future trajectory of a moving object based on previous experience, thereby intersecting vision and memory. Interestingly, the mechanism of pattern completion plays a big role in the reinstatement of memory traces in classical memory experiments. Whether the visual preplay effect is similar to the pattern completion in memory reinstatement, and whether the memory replay effect might be guided by visual preplay is currently unknown. The proposed project will provide a better understanding of the nature of the visual preplay effect and its relation to memory. It will investigate the neural oscillations induced by the visual preplay effect together with its temporal unfolding, providing insight into information processing and communication between brain areas. It will also examine a possible link between this visual effect and memory by embedding the preplay experiment into a memory paradigm. The combination of magnetoencephalography (MEG) and fMRI methods together with state-of-the-art signal processing and machine learning will enable a comprehensive investigation of this effect a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Community based prepayment and health insurance schemes in rural Burkina Faso and Ghana - an intervention study' (1994-1998).

assistant: **Concept**

To improve the health status of the general population in rural areas of Burkina Faso and Ghana by improving the quality of the health care system and ensuring equitable access to it through sustainable community-based prepayment and health insurance schemes.Specific objectives:Improve financial access to essential health services while reducing access differentials between rich and poor as well as children and adults;Design two alternative prepayment schemes (with and without risk sharing: health insurance vs. prepayment), based on the costs of services provision and the schemes' projected revenues (depending on the amount of contribution to the schemes and their coverage);Recover all recurrent non-salary costs of providing the essential care package;Improve the quality of care: 75% (up from 40%) of users are satisfied and 60% (up from 20%) of providers follow locally accepted diagnostic and therapeutic algorithms;Assess the effect of quality on participation in prepayment/insurance schemes;Measure the impact of the intervention on the economic burden of illness;Measure the impact of the intervention on morbidity and mortality;Evaluate the process and outcome of partnership between the Ministry of Health and autonomous church affiliated providers in the implementation of a rural health insurance scheme (Ghana).Expected OutcomeContinuous feed-back of concerned audiences (research community, policy makers, public health staff, local communities) will be given.The project will consist of three phases:Phase 1: Preparatory research (12 months), to a) design the modalities of insurance and/or prepayment scheme and b) establish the quality and the distribution of health care to be provided under the schemes. Essential care packages have to be defined, the innovative financing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'FUNCTIONAL FOOD SCIENCE IN EUROPE'.

assistant: **Concept**

Altered lifestyles in Western populations triggered a growing awareness that diet related health implications could be prevented by so called 'functional foods'. This term has induced much confusion by the fact that in principle all foods are 'functional'. Consequently the term functional foods currently in use is particularly unfortunate. It is adversely prejudicial to the concept and the future needs for developing modified foods designed to improve health. In view of the rapid development of the concept of functional foods in various regions in the world, together with the apparent misconceptions of the science behind functional foods, Europe should state its own position in order to maintain industrial competitiveness. Due to the fact that in most cases functional food development is product - rather than function-driven, the objective of the proposal is to develop a science-based approach for targeted modifications of food and food constituents.The project includes workshops and will involve a strategic collaboration between actors of the European Agriculture and Food Industry and the European Research Community. The key goals of the meetings are to define the present state-of-the-art, the identification and understanding of the interactions between specific dietary components and particular physiological functions related to health as well as the gaps in scientific knowledge and the need for future research. Moreover, it will establish concepts in functional food science and requirements for functional food applications. The project will lead to shared cost project applications. Its multidisciplinary character entails a joint strategy leading to the development of tailored foods and food constituents on a rational and sound scientific basis, which will benefit bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Light-activated carriers for the controlled delivery of therapeutic peptides in posterior segment eye diseases' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In 2016, the global sales of biopharmaceutical drugs (protein, peptides) in ophthalmic applications exceeded $8 billion and is estimated to increase to $35.7 billion by 2025. The growth of the ophthalmic drug market is primarily driven by an increasing aged population suffering from age- and lifestyle-related diseases such as macular degeneration, diabetic retinopathy, glaucoma, among others. These diseases cause moderate or complete vision loss, resulting in significant reduction in quality of life. Consequently, innovative approaches for the effective delivery of biopharmaceuticals for the treatment of chronic intraocular diseases are required.Currently, intravitreal injection of drugs is the most acceptable and effective method to treat vitreoretinal diseases. By placing the drug in the posterior eye, it evades the ocular barriers common in topical and systemic delivery, allowing higher drug doses to reach the target site. However, treatments require frequent injections to maintain adequate intraocular concentration, which are invasive, increase the risk of adverse effects and pose significant treatment burden on patients and healthcare providers. Thus, alternative ways to deliver these drugs that require less frequent administration need to be developed. Light4Sight aims to develop a novel delivery platform consisting of self-assembling nanocarriers incorporating therapeutic peptides and suspended within a light-sensitive supramolecular hydrogel. The hydrogel can be injected in the vitreous and release of nanocarriers be activated through the irradiation of visible light. This approach provides several benefits: 1) minimizes the use of repeated injections reducing treatment burden; 2) reduces burst release of the nanocarriers avoiding potential dose related toxicity