RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mitigating ADverse Ecological impacts of open ocean fisheries', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A particular attention has been paid worldwide on longline fisheries as they catch considerable amount of by-catch (seabirds, turtles, sharks, etc.). Seabird and turtles by-catch mitigation methods have now been established in many fisheries worldwide, but similar efforts must be put to reduce by-catch of sharks. In the same ecosystems, another issue attracts the attention of international tuna commissions: the use of drifting fish aggregating devices (FADs). These FADs are responsible for major catches of juvenile tuna and non target pelagic species (sharks). Finally, the effects of thousands of FADs released regularly in the tropical oceans are unknown, and must be studied to estimate if they impact the biology of pelagic species. The European open ocean tropical and Mediterranean pelagic fishery (Spain, France, Portugal, Italy, Greece) is one of the main sources of catch, income and employment for the European fishery, with interactions with many developing countries. The main objective of the project is to develop measures to mitigate adverse impacts of fisheries targeting large pelagic fish in the open ocean: purse seiners using FADs and longliners. Two main categories of mitigation measures will be studied: spatial management issues (e.g. closure areas) and technical solutions to reduce by-catch in these fisheries. The main concept of MADE is to follow a multi-disciplinary and comparative approach, combining biological and technological studies with economical analyses in different sites (Indian and Atlantic oceans, Mediterranean Sea), with a particular effort to closely associate fishers from the beginning of this research. High-tech technology and novel approaches will be employed (electronic tagging, in situ and in vitro experiments, etc.), and a particular eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Serotonin receptors and transporter: molecular, functional and therapeutic aspects' under Fourth Framework.

assistant: **Concept**

Serotonin (5-hydroxytryptamine, S-HT) is a major neurotransmitter in the central nervous system. Currently, 7 types (5-HT1 7) and no less than 15 subtypes of 5-HT receptors have been described. All of them are G-protein linked, with the exception of the 5-HT3 receptor which is a ligand-gated ion channel. 5-HT receptors appear to be involved in basic and integrated physiological processes of the brain (e.g. presynaptic control of neurotransmitter release, sleep, memory, mood) as well as in socially relevant pathologies (depression, generalised anxiety, obsessive compulsion, dementia, and parkinsonism) and the psychic effects of drugs of abuse (LSD, cocaine, ecstasy). All the above mentioned diseases share depressive symptomatology, and treatment with antidepressants proves to be of beneficial effect. One of the major targets of antidepressants is the 5-HT transporter, responsible for 5-HT reuptake by serotoninergic neurones. However, treatment with selective 5-HT transporter blockers produces profound modifications in 5-HT receptor responsiveness, which may be also involved in the therapeutic effects of antidepressants. The understanding of the mechanisms of cellular transduction of 5-HT receptor-mediated signals, as well as of plasticity and degeneration of the 5-HT system, is crucial for developing new drugs and pharmacological strategies for managing these pathologies. The proposed research aims to elucidatethe roles of 5-HT receptors and 5-HT transporter in physiology and pathology. The measurable objectives of the present proposal will be: 1) Development of a new preparation of purified serotoninergic synaptosomes suitable for studying, with patch clamp recording, the effects and the mechanisms of action of selective 5-HT agonists (or antagonists) on presynaptic ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimizing Selectivity in C-H Functionalization Through Computational Design' to be submitted under Seventh Framework.

assistant: **Abstract**

The activation of inert C-H bonds lies at the heart of organic chemistry. In particular C-H activation using transition metal catalysis has made a profound impact on complex molecule synthesis, but the area remains important for future discovery. At present the utility of synthetic methods based on C-H activation is hampered by the inherent difficulty of being able to selectively functionalize a single C-H bond in the presence of many others. Thus the ability to perform predictably site-selective C-H functionalizations on a given C-H bond in a complex substrate would be transformative for chemical synthesis.In this proposal we propose to perform computational studies on Pd-catalyzed C-H functionalization reactions, to uncover the inherent electronic bias of substrate structures on the site-selectivity. Calculations will be performed using density functional theory to characterize the mechanisms and catalytic cycle for Pd-catalyzed arylation of aromatic and heteroaromatic substrates. We will also develop quantitative models of reactivity and selectivity to deliver a greater understanding of the process, which will be used to generate predictions. The result will be a reliable predictive method with which to rationally design substrates and catalysts to deliver improved selectivities in C-H functionalizations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mapping of evolution and adaptation of the influenza virus hemagglutinin protein by glycan array cartography' (2007-2013).

assistant: **Innovation**

Influenza viruses belong to the family of Orthomyxoviridae and cause acute viral disease of the respiratory tract. Influenza virus enters the cell via receptor-mediated endocytosis and subsequent fusion with the cell membrane. Influenza virus hemagglutinin (HA) is responsible for these binding and fusion events. HA binds to sialic acid (SA) receptors on the host cell-surface. These SA receptors vary in structures and are species and tissue specific. The preference for a certain SA receptor is influenza virus specific; human and avian influenza viruses prefer (SA)-α2-6-Gal and (SA)-α2-3-Gal terminated structures respectively. Studies on the interactions of glycan binding proteins such as HA have advanced significantly since the development of glycan array technologies. Using this new technology it has been shown that the receptor specificity is more complex than previously recognized and is not solely dependent on the type of glycan sialic-acid linkage, but also involves glycan modifications, such as fucosylation, sulphation, etc. There is a huge potential in the use of glycan arrays in the understanding of receptor specificity, but a major drawback for this technique is the opacity of the array data, making it difficult to interpret the data and compare data of different arrays. We propose to set up glycan array cartography, a novel method for the analysis of glycan array data in clear accessible maps, providing a spatial layout of assay components (virus strains and SA receptors), allowing the precise measurement of distances and directions amongst components. These analyses will build on the expertise of the host institution on antigenic cartography. The glycan array maps will be thoroughly tested and linked to sequence data, classical binding studies, structural mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Reinforcing the Scientific Excellence of the Institute for Ethnopharmacological Studies and Phytotherapy (IESP) through Twinning with Computer Science (CS)'.

assistant: **Innovation**

The main goal of the “ETHCSTWIN'' initiative is to establish a collaborative network between the Institute for Ethnopharmacological Studies and Phytotherapy (IESP / NKUA University) with two highly renowned academic research teams from Italy (Research team of Prof. A. Pieroni) and Germany (Research team of Prof. M. Hofmann-Apitius), as well as Biotech SME PangeaAI and Uni. of Prishtina (Faculty of Mathematics and Natural Sciences) in order to incorporate ETH insights into novel computational and digital frameworks by focusing on developing a rich portfolio of complex methodologies and tools, encompassing the analysis of extensive big data sets and the restoration of both tangible and intangible heritage. Following thorough research and assessment of data derived from several ethnopharmacological sources (e.g. manuscripts, folklore texts, ethnobotanical studies, ETHCSTWIN's subsequent phase will involve knowledge transfer and capacity building in AI, Machine Learning, and Data Mining methodologies, as well as advancing ethnopharmacological studies among the project's partners. This newly acquired knowledge and capabilities will contribute to developing of the ETHCSTWIN platform, which will serve as a resource for data collection, processing, and creating an extensive relational database comprising a vast dataset repository. The project will establish an Ecosystem Excellence Aggregator, presented as an open science community, that will host the ETHCSTWIN database and toolkit and will offer support for stakeholder training. ETHCSTWIN will provide a unique opportunity for IESP and its partners to develop the first European Ecosystem with IESP as the Regional Research Centre on Ethnopharmacology and Phytotherapy, connecting the Balkans, Mediterranean, and Central Europe. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Corba Architecture for Legacy Integration and Migration' under Fifth Framework.

assistant: **Concept**

CALIM will establish a workable platform to support legacy applications integration and progressive substitution within answer strategic issues:- progressive abandon of legacy applications based on obsolete technologies,- use of current skills, with a limited assistance of new technology specialists.The platform includes process, methods and tools:- to automate the development and the deployment of a component-based IS,- to improve the reliability to the targeted IS (performance and fault-tolerance simulation)The platform will be tested by two partners representative of large industries. It will be based on a Corba architecture which makes possible to integrate heterogeneous technologies.Objectives:CALIM intends to provide practical answers (I.e. a process instrumented by method and tools) to the current issues that large companies have to face with their Information Systems:- Technical migration from existing applications based on obsolete or proprietary platform (e.g. IBM CICS) to component-based architecture (COTS like PDM or ERP). This technical migration will have to be progressive to maintain both solutions operational during the time needed for complete transfer.- Skills: the migration will have to be performed with the current available human resources assisted by a limited number of specialists in new technology. CALIM methods and tools to automate the IS migration and the exploitation will answer this. So far, Corba is the only proven solution which offers such capabilities (heterogeneous technology co-existence and industrial standard used by PDM or ERP vendors) and will be used as a means for CALIM demonstration.Work description:Process elaboration: selection of object-oriented process. Introduction of steps respectively dedicated to: - Simulation (Informati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Harnessing RARA signalling for curative AML therapies'.

assistant: **Innovation**

In acute promyelocytic leukaemia (APL), retinoic acid (RA) and arsenic trioxide (ATO) bind the PML/RARA fusion to promote its degradation, derepressing unknown master regulatory genes and activating a PML/P53 checkpoint which is required for APL cure. APL initiation deregulates Retinoic Acid Receptor a (RARA) signalling. These deregulations are likely shared with a sizable subset of non-APL acute myeloid leukaemia (AML): the 30% that overexpress normal RARA and exhibit some RA-sensitivity ex vivo. Clinical trials have demonstrated some benefit of RA addition to conventional therapies in non-APL AML patients, but have not resulted in the incorporation of RA into standard therapies. Thus, modulation of RARA signalling is an unrealized target for treatment of non-APL AMLs. Of importance, RARA serves a dual function in APL by promoting leukemogenesis in the unliganded state, but also by enforcing RA-response. We made the striking observation that overexpression of RARA suffices to confer cell self-renewal ex vivo and RA-sensitivity in several AML models. We propose to i) define the actual effects (differentiation, self-renewal) and cellular mechanisms (senescence, apoptosis, growth arrest) underlying RA action on a variety of primary myeloid cells over-expressing RARA ii) delineate the mechanism(s) underlying RARA overexpression in some human AMLs iii) identify the RARA downstream targets that drive self-renewal iv) discover novel RA-containing drug combinations exhibiting synergies for AML clearance in RA-sensitive transformed myeloid cells. This proposal is based on our previous modelling of APL therapy and recent disruptive observations. This renewed exploration of RARA-driven progenitor self-renewal will allow us to define novel curative RA-containing strategies and bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ICSE Science Factory' (ICSEfactory).

assistant: **Innovation**

The ICSE Science Factory supports the EU’s endeavor to combat a shortfall of scientists and citizens versed in science. It does so by offering a unique combination of different measures, each of them tackling the issue from a different starting point, thereby leveraging impact. The unique features of the ICSE Science Factory are, in a nutshell:• New high-capacity cross-sectoral partnerships in five partner countries consisting of science researchers, science education researchers and non-formal education providers, supported by attached schools, enterprises and community institutions.• Innovative concept to enlarge the number of scientists and scientific knowledge in the communities: 1.To strengthen the partnerships, we organise local partnership conventions, where we share and apply research findings, and local public fairs to integrate communities in the scientific learning process. 2.With the expertise of the local cross-sectoral partnership, in each country we offer collaborative and interdisciplinary lighthouse activities and open schooling activities for community members (on health, digitalisation, Green Deal), supported by mentoring. 3. All activities are complemented by a series of interactive career talks, focussing especially but not only on female role models in science and on overcoming stereotypes. • An educational, research-backed concept for our lighthouse and open schooling activities which deliberately includes real-life problem-solving on issues relevant to society (including decision-making), and the concept of challenge-driven innovation, which integrates communities in overcoming challenges.  •The activities are supplemented by special features: The setting up of stimulating science labs in each country, a threefold system for encouraging mentoring
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nurturing the Development of Information Seeking Skills' (InfoSeekDev), addressing dissemination and exploitation.

assistant: **Impact**

The ability to search for information effectively and efficiently is central to academic and professional success. Understanding how children learn to seek information is a topic of immense importance for society, for parents, and for educators. Active learning – searching for information effectively and efficiently – requires the coordination of complex cognitive processes: the ability to generate, evaluate, test, and update one’s hypotheses about the world. Four skills critical for active learning develop between 3- and 10-years old: the ability to formulate effective questions from scratch, the ability to reason about uncertain events and to use that information to guide one’s search, the ability to adapt one’s search strategy based on feedback and task characteristics, and the ability to monitor the search process and stop searching when enough information has been collected. This project builds on this work to ask a critical but unanswered question: what factors support the development of these active learning skills and explain individual differences in them? Based on prior research, this project targets two factors: children’s cognitive skills and their socio-cultural environment. The first phase of the research is diagnostic and will explore using observational and correlational methods the associations and unique contributions of cognitive skills and socio-cultural input on children’s active learning skills. The second phase will use insights gained in Phase 1 to develop an intervention designed to boost children’s active learning skills. It will allow us to assess the causal impact of socio-cultural input and cognitive skills on the development of children’s active learning capacities by manipulating them experimentally. Because the acquisition of information
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Combining wood and polymers to produce a translucent, reinforced and ecological material' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project POLYWOOD (Combining wood and polymers to produce a translucent, reinforced and ecological material) is mono-partner, lead by French startup WOODOO, and responds to the call topic “Coordination and support actions, H2020 SME Innovation Associate”. WOODOO has developed a breakthrough patented technology, focusing on wood modification at the cellular and molecular scale. It starts from native wood, removing lignin and impregnating the cellulosis matrix with selected monomers, polymerizing in situ to create much stronger bonds between the wood native fibers. The result is a translucent wood, three times stiffer than natural wood, much more durable, water and fire resistant.Research has been done before on de-lignification and on the monomeric impregnation of wood, but never have they been combined in the way WOODOO does, with a direct and highly promising application potential across various industries. The industrial development of this process could establish Europe as a world leader on the market of bio-based materials. In alignment with the new EU forest strategy (EC, 2013), WOODOO will help unfold the potential of the European forest. This bio-based, low-carbon material will help tackle the urgent need of lowering the carbon footprint in the building industry.WOODOO offers a 12 month position to a European material science researcher, with a strong knowledge of functional monomers, wood structure, and industrial processes, in order to reach its next objective: bringing the technology from the lab to the market. The research associate will take full advantage of WOODOO international team, as well a use an occasion to show polyvalence, leadership and commitment in the exciting environment of a booming startup, awarded with multiple innovation awards. The POLY