RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES' under Horizon 2020.

assistant: **Concept**

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. This mortality is mainly due to cirrhosis decompensation, i.e. development of ascites, hepatic encephalopathy, and/or gastrointestinal hemorrhage, and its progression to acute-on-chronic liver failure (ACLF). Patients with decompensated cirrhosis receive many treatments such as intravenous and oral absorbable antibiotics, oral non-absorbable antibiotics, albumin, proton-pump inhibitors, laxatives, diuretics, betablockers, vasoconstrictors, statins, anticoagulants, steroids and antiviral agents. Despite these multiple treatments, ACLF or mortality in patients with decompensation of cirrhosis remains high (15% at day 28, 28% at day 90) because of large interindividual variability in precipitating events, in clinical presentation and in response to treatment. This heterogeneity calls for treatment personalization according to underlying mechanisms. The objective of DECISION is to enhance our understanding, at systems level, of the pathophysiology of decompensation of cirrhosis leading to ACLF or death to decrease patients’ mortality at day 28.First, DECISION will improve our knowledge of the pathophysiology of decompensation of cirrhosis by integrating results of high-throughput multi-omic profiling with comprehensive clinical data from 2,200 fully characterized patients (more than 8,600 time points) with available standardized biological samples. Second, we will identify novel combinatorial therapies for patients with decompensation of cirrhosis to prevent death. We will refine these therapies in new and/or optimized animal models and then test the best combination in high risk patients in a phase II clinical trial built in DECISION. Third, we will develop 2 tests: one predicting outcome of patients with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Heterogeneous Single-Atom Catalysts for Carbon Dioxide Reduction to Chemicals' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The increase in global energy consumption has been relentless as a consequence of population growth, higher living standards, and industrial expansion. This has caused, in turn, acute problems with the release of vast amounts of carbon dioxide (CO2) into the environment, which is linked to ocean acidification, global warming and extreme weather conditions. Finding new routes to strategically capture, mitigate, and utilize CO2 is thus a priority.The catalytic conversion of CO2 to chemicals is a promising pathway for transforming this “waste” into a precious platform molecule, but the approach is still in its infancy. The SACforCO2 project will decisively contribute towards this effort by designing a novel class of single-atom catalysts (SACs) for a new purpose: the conversion of CO2 to make higher alcohols. To this end, SACforCO2 will adopt an interdisciplinary approach which combines organoligand-based synthesis, advanced characterization, and a close synergy between experimental and theoretical research to gain a deep understanding of the N-based surface functionalization that guides single atom anchoring. By integrating SACs into 3D printed membranes, the project will also set up the technology for a cost-effective conversion of CO2 to chemicals. This will provide fresh perspectives in catalyst design and build bridges between fundamental efforts on materials and device engineering, achieving breakthrough performance under realistic conditions.Furthermore, this action will establish an intra-European interdisciplinary network between emerging researchers in academia and industry, at POLIMI (Italy) and VITO (Belgium), and will allow an Experienced Researcher to consolidate a diverse set of scientific and soft skills, gaining cutting-edge research competences, new crede
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bio-inspired 3D bioelectronic model of the intestinal crypts' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Organ-on-a-chip (OOC) technology represents an important tool in the field of molecular biology, offering a platform that mimics the complex structure and function of human organs in a controlled laboratory setting. These systems have the potential to host biologically complex 3D cell co-cultures, allowing researchers to study cellular behavior in a more physiologically relevant environment compared to traditional 2D models. Due to their ability to closely mimic human physiology, these systems are rapidly gaining popularity, as they exhibit high predictive power for clinical outcomes and may one day replace the use of animal models. The central aim of the proposed project is to increase the biological complexity of bioelectronic intestine-on-a-chip models by incorporating the tissue structures, cell types, and microbes essential for healthy gut function. The first objective is to 3D print a conductive polymer scaffold that recapitulates the 3D structure of colonic crypts and the microporous architecture of the extracellular matrix. This scaffold will be integrated into the E-transmembrane, a device developed by the Owens group at the University of Cambridge, and validated using a cell line model of the intestinal epithelium. The second objective involves replacing the cell lines with dissociated primary intestinal organoids on the 3D scaffold to achieve the epithelial cellular diversity of the gut and form a stem cell niche at the base of the crypts. Finally, human whipworm will be introduced into the model to further understand parasitic infections in the gut. Through the combination of molecular assays, imaging techniques, and electrical measurements, insights will be gained into the complex interactions between cells, parasites, and biomaterials within the OOC system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ubiquitous Quantum Communications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

''It is difficult to make predictions, especially about the future'' - Mark Twain.Yet, Gordon Moore's predictions - known as Moore's Law - made in 1965 remained valid for half a century!As a result, semi-conductor technology is approaching nano-scaleintegration and on this journey to quantum futures the travellerenters the world of quantum physics, where many of the phenomena arerather different from those of classical physics. This proposalcontributes to the 'quantum jig-saw puzzle', with special emphasis onthe enabling techniques of ubiquitous quantum communications,potentially leading to job- and wealth-creation on a similar scale tothe economic benefits of flawless classic wireless communications.My ultimate goal as a telecommunications researcher is to buildbridges across the exciting fields of quantum physics, mathematics,computer science and hardware aspects of quantum communications.Specifically, the three Key Challenges of Work-Packages 1-3 on the newconcept of Pareto-optimum error control, secret key-distribution,network coding and entanglement distribution will lead to creatingstepping-stones for the Grand Challenge of Work-Package 4, dedicatedto the support of quantum-communications for aircraft 'above theclouds'.Methodology: theoretical performance bounds will be established based on the hitherto unexplored Pareto-optimum quantum design  philosophy using multi-component optimization. Explicitly, thePareto-front of optimal solutions will be found off-line, where noneof the conflicting parameters, such as the bit-error ratio, transmitpower, delay and implementation complexity can be improved withoutdegrading some of the others. A suite of new soft-decision aidedcomponents will be conceived by invoking code-specific quantumsyndrome decoders to be designed for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Psychobiological factors of vulnerability to drug addiction in an animal model of human adolescence' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content  Certain human individuals (sensation seekers) are often involved in both risky activities and psychoactive drug use. A common neurobiological substrate (namely the mesolimbic dopamine system) has been hypothesized to be involved in both novelty seeking and drug use. In the same frame, adolescent human subjects are characterized by elevated levels of sensation seeking, which can perhaps justify the first approaches to recreational drug use. Aim of the present proposal is to specifically investigate this relationship, and to deepen our knowledge on psychobiological risk factors for vulnerability to addiction in an animal model of human adolescence. When compared to adult subjects, periadolescent rats are generally hyperactive, and show both a marked hyporesponsivity to acute psychostimulants effects and peculiar sensitization patterns after repeated drug administration. These age-related differences in response to drugs are suggestive of a differential activation of neural substrates involved in the reinforcing properties of psychostimulants. In animal models of vulnerability to addiction, namely the self-administration paradigm, a relationship between the behavioural and neuroendocrine response to novelty and the effects of psychostimulants has been established. However, these studies have been limited to adult animals. It is proposed the adoption of this kind of analysis in periadolescent rats, in the hypothesis that periadolescent subjects might show an increased vulnerability to drug addiction. The experimental animals are represented by either 60 periadolescent (postnatal days 35-45) or 60 adult S.D. male rats (postnatal days 70-80). Levels of novelty seeking will be assessed, and a fine-grain behavioural analysis will be performed on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'High Performance Environmentally Benign Quantum Dot@Perovskite Hybrid Materials for Near-IR LED: Design, Photodynamic Behaviour to Device Fabrication'.

assistant: **Concept**

In line with the European Energy Strategy on H2020, intensified research on the development of more-efficient and cost-effective light emitting diodes (LEDs) is required. In this regard solution processable colloidal quantum dots (QDs) and metal halide perovskites (PS) showed excellent proficiency to realize effective devices with low fabrication cost on large-area and light-weight substrates. Despite the high potentiality of developing advanced LEDs by exploiting the combination of PS and QDs, the investigation of the interactions of both materials is still in its early stage; and much is yet to be discovered regarding the charge-transport dynamics, mobilities, and defect states in different compositions of these hybrid materials. Our project's research objectives address this crucial issue and focus on designing novel, lead-free, QD@2D-PS hybrids, optimize their composition through studying their electro-optical properties, and finally characterize their performance in LED devices. The project (LED4Nature) will provide detailed knowledge about the effectiveness of Sn based 2D PS as a matrix for lead-free near-IR emitting QDs, and understanding of the effect of structural modifications (QD size, shell thickness, and PS's cation) on their spatially- and temporally- resolved photo-induced phenomena by time-resolved transient absorption and femtosecond terahertz spectroscopy, along with fluorescence lifetime imaging microscopy. Such information will be essential for the optimization and acceleration in the development of LED devices based on these hybrid materials which will be achieved through planned secondments to an expert group- and is expected to have significant industrial and socio-economic impacts. Comprehension of such multidisciplinary project will not only pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Seismic-Initiated events risk mitigation in LEad-cooled Reactors' (SILER) targeting Seventh Framework.

assistant: **Abstract**

SILER is a Project aimed at studying the risk associated to seismic initiated events in Generation IV Heavy Liquid Metal reactors and developing adequate protection measures.The attention is focused on the evaluation of the effects of earthquakes (with particular regards to beyond design seismic events and tsunamis) and to the identification of mitigation strategies, acting both on structures/components design as well as on the development of isolation devices, which can also have positive effects on economics, leading to an high level of plant design standardization. Attention is devoted also to the identification of plant layout solutions able to avoid risks of radioactive release from both the core and other structures (i.e. the spent fuel storage pools). Specific effort is devoted to the development of guidelines and recommendations for addressing the seismic issue in next generation reactor systems.In addition, consideration will be devoted to transfer the knowledge developed in the project to Generation III advanced systems, in line with the objective of the SNE-TP SRA to support present and future Light Water Reactors and their further development, for which safety issues are key aspects to be addressed. Note, in this respect, that the benefits of seismic isolation in terms of response to design seismic actions are already widely recognized for Generation III LWRs, along with the possibility of a significant standardization of structural and equipment design.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Algorithmic Foundations of Large Markets' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of this proposal is to study the theoretical foundations of computationally efficient large markets. Market Design is a task that is traditionally carried out by economists and game theorists. However, as markets are becoming larger one must take into account computational considerations as well. The field that integrates methodologies from classic mechanism design and computer science is called Algorithmic Mechanism Design.Specifically, Game Theory and Mechanism Design study how selfish players interact. A traditional example is an auction for a single item, where mechanism design studies how to achieve a certain goal, e.g., social welfare or revenue maximization. However, when there are multiple heterogeneous items that may exhibit complementarities and substitutabilities, designing mechanisms becomes much more challenging. While classic mechanism design does offer some solutions, these solutions usually do not scale well, as they are not computationally efficient. The goal of this proposal is to understand whether this gap can be bridged.Most research in Algorithmic Mechanism Design focuses on dominant-strategy auctions, where every bidder always has a bid that is at least as good as any other possible bid. This proposal has two related objectives: (1) prove that in some settings there are no computationally efficient dominant-strategy mechanisms, and (2) develop techniques that will allow characterizing the set of dominant-strategy mechanisms in important auction domains, and design new families of dominant-strategy mechanisms.The proposal is expected to advance the state of the art in problems that are at the heart of Algorithmic Mechanism Design (and, more generally, at the heart of Algorithmic Game Theory).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'BusIness ONtologies for dynamic web environments' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

BIZON is an innovative approach to dynamic value constellation modelling and governance for e-business. The main goal is to design and build a knowledge founded framework (consisting of ontologies, knowledge bases, semantic Web, Web data mining, machine learning) able to support and optimise a business environment characterised by product personalisation, demand anticipation and process selforganisation.BIZON is conceived for use in value constellations with the following features:- Business actors that consist of a multiplicity of sellers, buyers, producers, each of them with their own distinct features;-- Actors exchange goods (products and services) which can be material or immaterial, but in any case contain a high degree of embedded knowledge. The sectors targeted as examples in this proposal will be the goods and services of the publishing and knowledge management industries;- The goods considered are complex, and can be generated as variations and combinations of simpler goods. Goods production (e.g. variation and combination) and delivery requires planning of processes under economic and time constraints. Process planning requires co-ordination among actors (sellers and producers, but also buyers);- Actor behaviour is simultaneously co-operative (to generate value) and competitive (to divide the generated value);- The value constellation is dynamic in all its components. As time proceeds, actors can leave the constellation and new actors can enter it; the behaviour of each actor is subject to evolution; goods evolve as well, and follow their own life cycle, sometimes very short.In the context of the features outlined, BIZON models the value constellation by means of a formal ontology. The ontology is built around the fundamental concept of value.The e-business m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Holocaust Research Infrastructure' (EHRI), addressing dissemination and exploitation.

assistant: **Impact**

In the year the world commemorates the 65th anniversary of the liberation of Auschwitz, a European Holocaust Research Infrastructure (EHRI) project sets out to support research into the Holocaust. EHRI’s main objective is to support the European Holocaust research community and help initiate new levels of collaborative research through the development of innovative methodologies, research guides and user-driven transnational access to research infrastructures and services. To this end, EHRI proposes to design and implement a Virtual Research Environment offering online access to a wide variety of disparate and dispersed key Holocaust archival materials and to a number of online tools to work with them. Building on integrating activities undertaken over the past decades by the 19 partners in the consortium and a large network of associate partners, EHRI sets out to transform the data available for Holocaust research around Europe and elsewhere into a cohesive corpus of resources.EHRI will first and foremost strengthen the existing clusters of excellence in Holocaust research, but also serve as a 'best practice' model for other archival or humanities projects as well as for more encompassing follow-up projects in contemporary history. Although EHRI is primarily geared towards the needs of scholarly communities, the online availability and open access to reliable and properly contextualized Holocaust material is relevant and important for the larger public well beyond scholarly communities, as its research topic is deeply rooted in the development of European societies. European support and a European approach are essential to achieve an integral and comprehensive approach to the history of the Holocaust as a European phenomenon.