RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Theoretical and empirical approaches to understanding Parallel Adaptation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Adaptation is a key evolutionary process, allowing organisms to thrive in different environments. Studying adaptation is important for understanding biodiversity, and for addressing pressing issues in conservation and medicine. A crucial question is whether adaptive evolution is repeatable and therefore predictable. Patterns in nature suggest that this may be the case: within many species, similar adaptive phenotypes have evolved repeatedly in multiple geographical locations (“parallel evolution”). However, it is often unclear whether the genomic basis underlying parallel phenotypes is the same across locations (e.g. due to mutations in the same gene, or gene flow between locations).With high-throughput DNA sequencing technologies, it is now possible to address this question in unprecedented detail. However, we are lacking a theoretical framework predicting the genomic basis of parallel evolution, as well as powerful analyses of empirical data. Therefore, here I propose an interdisciplinary approach with the following aims:1. Using computer simulations to study the effects of demographic history and polygeny on the genomic basis of parallel evolution. This will, for the first time, enable quantitative predictions. 2. Generalising the model outlined in 1. by describing it mathematically.3. Exploring the genomic basis of parallel evolution in an ideally suited organism. I will identify the most powerful analytical methods, and apply these to generate one of the most comprehensive empirical studies so far.This project will be of use to other researchers conceptually, for making system-specific predictions, and by providing widely applicable workflows. It will facilitate new collaborations between my host group (focusing on mathematical analyses of evolutionary processes) a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hypermedia and Pattern Based Knowledge Management for Smart Organisations' in the context of a Fifth Framework call.

assistant: **Objectives**

Information-age organisations need to utilise knowledge about their business and organisational practices as well as knowledge of the environment. Verbundplan, the consulting daughter of a major European energy supplier (Verbund, Austria) needs improvement of leveraging incompletely specified corporate knowledge and in-house expertise in the strong competition of the deregulated energy market. The City of Riga, Latvia, needs it for improving management processes.With a focus on smart" organisations, we propose two applications of novel technology and approach to knowledge management, based on participatory business modelling. This technology is an integration of the EKP (Enterprise Knowledge Patterns) method developed at KTH, Sweden, and the hypermedia- based RETH tool developed at Siemens Austria. Once the business knowledge is represented in RETH, it is easy to use through the intranets, supporting process distribution and optimisation.Objectives:This project aims to achieve 2 objectives.The user organisations want to improve their work practices through participatory business modelling as well as exploiting knowledge in support of organisational activities, in the spirit of "smart" organisations.The providers want to customise and validate the yet untested integration of their novel technologies in these real-world environments prior to commercialisation.Verbundplan needs to leverage incomplete specified corporate knowledge in the strong competition of the deregulated energy market. The City of Riga, Latvia, needs it for improving its management processes. By achieving those objectives in this project, primarily the EC objective of efficiency improvements is supported.Work description:The novel technology to be used for achieving these objectives is an integration of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing a validated technology platform for the application of oxygen dependent enzymes in synthesis and transformation of alcohols', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Currently the aerobic bio-catalytic oxidation reaction is the one that would have the biggest impact on the future uptake of industrial biotechnology in Europe. Chemical oxidation is both hazardous and has high environment impacts. Many oxidative bio-catalytic reactions and transformations have been identified in academic laboratories but only a very small number have been applied by industry to oxidize non-natural substrates.Hence biocatalysis for oxidative chemical manufacture processes can deliver a major advantage to the European chemical-using industries and the environment. In this project we intend to develop the tools for implementation of bio-oxidation to synthesize and oxidize alcohols.Cytochrome P450 enzymes will be investigated for hydroxylation of fatty acid derivatives and terpenes which have potential to be used in biopolymers and fragrance chemicals respectively form one line of investigation. The second is the selective oxidation of primary alcohols to give products with added value in their own right and as intermediates towards other valuable products.To support the implementation culture collections and literature reported DNA sequences will be used to identify diverse enzymes with predicted oxidase activities, which will be used as starting point for an enzyme improvement program. Then fermentation and enzyme formulation techniques will improve reaction performance to a level where useful quantities of target products can be produced for evaluation by industrial partners, and engineering techniques will analyse and implement reactor configurations that will further improve this technology platform to enable this technology to be introduced as a routine technology in the IB industry and support the European KBBE.Further a dynamic public engagement an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Specific Conjugation of Antibodies to Lipid Photo-peroxidised cancer tissues for their immunogenic ELimination' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer ranks as a major cause of death, with 3.4 million new incidences in 2020 in Europe. The current cancer standards of care include surgery, chemotherapy, radiotherapy and, as of late, immunotherapy, none of which have met their expected therapeutic outcome yet. Photomedical treatments like photodynamic therapy of cancer (PDT) and Photochemical Internalisation (PCI) show great promise as effective anticancer treatments. Both are, however, limited by the cancer cells left behind, causing cancer recurrence and metastasis, after recovering from their sublethal membrane injuries.But what, if we could label these injured cancer cells with antibodies, thus activating the immune system to eradicate them? SCALPEL will utilize PDT or PCI to destroy the bulk of tumour cells while marking the remaining sub-lethally damaged cancer cells for destruction, by attaching antibodies to their membranes. Bespoke, modified SCALPEL components will be administered to all cells, normal and cancerous. Following local irradiation, only the photo-modified components will conjugate with our specially engineered antibodies, selectively flagging the cancer cells, for destruction. Moreover, the immune system will be trained through this process, against the specific cancers offering systemic immunity.The high risk/high gain nature of SCALPEL is counterbalanced by an avant-garde, multidisciplinary research team, covering photomedicine/photobiology, immunology, synthetic chemistry, porphyrin chemistry and protein engineering. SCALPEL is expected to revolutionize oncology by offering a pioneering photoimmunotherapy with curative potential. In this project, we strive to provide a proof-of-principle of the proposed technology in cell cultures, but also in laboratory animals, with the long term-vision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'GPCR oligomers: Facts and function for the GABAB receptor', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

G protein-coupled receptors (GPCRs) are key players in cell communication and represent the largest class of drug targets. However, GPCR lead compound development has suffered from a low success rate the last 10 years, likely because these receptors are more complex than initially thought. GPCRs are known to form dimers and higher oligomers with specific properties, but the physiological relevance of this oligomerization remains elusive in native tissues. Deciphering the precise functional consequences of GPCR oligomerization is a major challenge in the field and of primary importance to stimulate further drug development.The GABAB receptor – the GPCR for the main inhibitory neurotransmitter, GABA – is an excellent model for studying GPCR oligomerization: Not only is it an obligatory heterodimer composed of GABAB1 and GABAB2 subunits, but it was recently demonstrated by the host laboratory that the GABAB receptor can assemble into larger entities through a direct interaction of the GABAB1 subunits, both in transfected cells and in brain membranes. The aims of the present project are to (i) Identify the stoichiometries and dynamic properties of GABAB oligomers at different localizations in primary neurons, (ii) identify the molecular mechanisms that regulate the GABAB oligomer stoichiometry and characterize them in vitro, and (iii) determine the functional significance of the GABAB oligomers. To reach these goals, we will develop innovative microscopy techniques for quantitative analysis of GABAB oligomerization and novel fluorescent tools for labeling of GABAB in neurons in collaboration with a biotech company.By using state of the art technologies, this study will bring the first clear demonstration of the existence, regulation and functional relevance of GABAB oligome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ASTRocyte Adrenoceptors: Light on Intracellular Signaling' under Horizon 2020.

assistant: **Concept**

ASTRALIS proposes all-optical strategies to shed light on holes in our understanding of how intracellular signaling complexity, downstream of specific G protein-coupled receptors (GPCRs), is generated in the brain. We focus on the understudied cells of the brain, astrocytes, which are highly interconnected but electrically silent, and signal through GPCRs and second messengers in response to norepinephrine (NE). We use them as models to study whether intracellular signaling in vivo is governed extrinsically, by noradrenergic afferent fibers releasing neuromodulators in defined spatiotemporal patterns –and therefore by receptor-specific activation dynamics– or rather intrinsically, by compartmentalization of cellular components, resulting in spatiotemporally different signaling outputs. During the outgoing phase, I will use advanced optical approaches to: (1) measure the spatiotemporal dimension of NE release in vivo, and (2) characterize the cellular and subcellular heterogeneity of astrocytic signals in response to NE in vitro and their relevance to the circuit, by simultaneously monitoring astrocytic and neuronal activity. During the incoming phase, I will (3) combine knowledge generated within the outgoing phase about in vivo noradrenergic signaling with the optical technologies developed by the host lab, in order to dissect the contribution of receptor dynamics to the spatiotemporally defined signaling of adrenoceptors. Significance: Current strategies to study intracellular signaling downstream of GPCRs widely neglect the spatiotemporal component of the inputs to which receptors are exposed naturally. Clarifying these aspects of receptor function would radically change the way we probe and study these proteins. In addition, elucidating the largely disregarded contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Network for European Research and Innovation acceleration in the US'.

assistant: **Concept**

NearUS aims at establishing a Butterfly Network of Centres of European Research and Innovation as central contact point for support to EU research and innovation (R&I) actors seeking collaboration with and in the US. The NearUS Network/Centre will be coordinated through two nots in the EU and the US and be physically established in two main locations of interest (“landing hubs”) in the heart of the US eco-system: Silicon Valley and Boston. Additional network members will be added through “Associated Centres”, and the network establishment will build on strong existing ties, ensuring access to EU potential beneficiaries from all EU Member States and US actors from all over the US so as to set up a consolidated structure of support: the currently dispersed services from a multitude of EU and EU Member States initiatives will be brought under one umbrella.In order to ensure a sustainable set up and implementation of the Butterfly Network of Centres of European Research and Innovation, the project team will proceed with a clear methodology: Firstly, an analysis of the existing offer combined with a needs analysis from potential customers will be undertaken, as well as the set-up of an operational roadmap based on a subsequent gap analysis.  The establishment of the two pilot “soft landing” hubs with adapted business models and concrete business plans will follow, as well as long-term financial planning. A variety of services will be developed and proposed to customers during a pilot phase, then the centres and their pilot activity will be evaluated and the activity where necessary optimized so as to ensure the sustainable implementation. Services will target R2R, R2M and B2B cooperation, such as matchmaking opportunities, working visits to US institutions, pitching in front
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Characterization of regulatory roles of SWI/SNF-type chromatin remodelling complexes in the control of development and hormonal, biotic and abiotic stress responses in Arabidopsis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Chromatin remodelling complexes (CRCs) of the SWI/SNF family are implicated in numerous regulatory processes of eukaryotic growth, differentiation and development. Multiplicity of genes encoding SNF2-type ATPase and SWI3-type SWI/SNF CRC subunits in Arabidopsis suggests that CRCs carry different combinations of these core components. In yeast two-hybrid screens, we have identified potential auxiliary proteins of Arabidopsis SWI/SNF CRCs and analyse their in vivo interactions with CRC core components by FRET assays. We also accomplished subcellular localization of core CRC subunits by in vivo imaging and established a powerful technology for purification of SWI/SNF CRCs. Our results indicate that the BRM ATPase and ATSWI3C CRC subunits occur in common SWI/SNF complexes and mutations inactivating their genes cause similar phenotypic changes. By Affymetrix transcript profiling and qRT-PCR studies, we have identified a set of genes, which show similarly altered transcription in the atswi3c and atbrm mutants. Furthermore, we characterized genetic interactions of atswi3c mutations with known mutations that affect the functions of key genes controlling physiological and developmental responses to different hormones, and stresses. The proposed reintegration project is based on a focused multidisciplinary approach aiming at precise definition of regulatory functions of SWI/SNF CRCs. Complementary tasks of the experimental work plan aim at the i) identification of primary regulatory targets of SWI/SNF CRCs using transcriptome analysis in combination with inducible knock-down SWI3 subunits; ii) mapping of SWI/SNF-binding domains in target genes using chromatin precipitation; iii) analysis of SWI/SNF CRC-regulated functions in stresses and pathogen signalling pathways. The project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'IndeSent: Indeterminate sentencing and imprisonment – an interdisciplinary study of the experiences of court processes and prison practices' (IndeSent), addressing dissemination and exploitation.

assistant: **Impact**

In Denmark, indeterminate sentences are given to people who commit serious offences (murder, aggravated violence, sexual offenses, arson, and robbery) and who are deemed likely to reoffend due to previous offending and their mental state. They are held in prison indeterminately in order to protect the public and enable rehabilitation - a practice which is in line with the Council of Europe’s recommendations. Indeterminate sentences have one particular feature that sets them aside from all other types of imprisonment: there is no guarantee of ever being released. This uncertainty often results in severe pains for the prisoners in question. While there is a fairly rich literature on indeterminate imprisonment in the Anglo-phone countries, the last explorative study of indeterminate imprisonment in the Nordic countries was conducted over 50 years ago, hence our understanding of contemporary experiences of indeterminate confinement remains very limited. IndeSent responds to the Council of Europe’s call for more research focused on the needs of the offender in the light of the negative effects of the often long-term imprisonment. The research project will provide an in-depth examination of the experience of being indeterminately sentenced by a court and of serving an indeterminate sentence in prison. The combination of courts and prison practices is one of the most pioneering aspects of the proposed research, illustrating the connections between the wider aims and functions of the penal state and the everyday practices, experiences and interactions in prison. Usually, there is a sharp distinction between the allocation and delivery of punishment; the first happens in courts and the second in penal institutions. Using ethnographic research methods (participant observation, in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Housing for immigrants and community integration in Europe and beyond: Strategies, policies, dwellings, and governance' under Horizon 2020.

assistant: **Concept**

The MERGING project is an interdisciplinary study of migrant integration through participatory housing initiatives. The project brings together 7 disciplines from 10 partners to test an innovative approach aiming to facilitate and ensure the sustainability of migrants’ integration process. MERGING reviews existing knowledge, integration policies and initiatives across macro (EU migration policies), meso (regional economic & social systems) and micro (individual practices) levels in which housing occupies a prominent place. This will enable us to study the feasibility of participatory pilots in order to implement, test and evaluate them in 3 European regions. To ensure the success and the sustainability of the project, both immigrants, hosts, volunteers, NGOs, companies, citizens will be involved in the construction (or renovation) of housing. The innovative, multi-method approach (e.g. interviews, focus groups, policy analyses, quantitative data analysis and participatory action research) provides in-depth analyses of: 1) the long-term effects of participatory housing initiatives; 2) factors fostering or hindering integration processes of migrants and access to civic rights in local communities; and 3) how diverse stakeholders can support migrants by strengthening their socio-economic integration through participatory initiatives (notably the ones related to housing). MERGING will contribute extensively to integration studies - empirically, methodologically and conceptually - through its place- and migrant-centred approach. MERGING offers direct benefits to migrants and evidence-based policy-recommendations will help to push policy and practice innovation in the field of migrant integration in Europe.


**Keywords:** Housing,  Accomodation, Case studies,  Feasibility st