RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Predictive Microstructural Assessment and Micro-Mechanical Modeling of Deformation and Damage Accumulation in Single Crystal Gas Turbine Blading' (MICROMOD-SX).

assistant: **Innovation**

European gas turbine manufacturers have a strong need for improved methodologies for predicting the deformation and failure of turbine blades for advanced engines with increased thermal effeciency. Such predictive methodologies are needed for (i) avoiding catastrophic failure and also (ii) to assure that the critical components are utilised most efficiently. Particularly the full advantage of single crystal superalloys is not currently being achieved because of a lack of basic understanding of the anisotropies and defect structures associated with processing, deformation and failure. The work proposed here is directed to developing an improved basis for accounting for the anisotropic mechanical behaviour of single crystal superalloys under conditions relevant to service. The present program represents the first attempt at including the cast defect structure in a model for predicting deformation and failure of gas turbine blading. The predictions of the model will be validated by discriminatory mechanical testing, such as multiaxial creep and thermal fatigue tests. The major research tasks are: Establishment of a database of creep and LCF tests for carefully characterised crystal orientations, (2) metallographic identification and characterisation of deformation and damage mechanisms using OM, SEM and TEM in combination with image analysis, (3) micromechanical modeling to establish a physically based life prediction methology which adresses damage accumulation and failure, (4) multiaxial and thermal fatigue benchmark testing of single crystal specimens, including specimen surface imaging, (5) validation and refinement of a unified deformation and damage model with the results of (4) and (6) assessment of the validated model with appropriate material databases using the m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SAFE AND FLEXIBLE INTEGRATION OF ADVANCED U-SPACE SERVICES FOCUSING ON MEDICAL AIR MOBILITY' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The SAFIR-Med project’s vision is to achieve safe, sustainable, socially accepted and socially beneficial urban air mobility.   SAFIR-Med represents all value chain actors and stakeholder as either project partner (ATC, USPs, Operators, UAS Manufacturers, cities) or formal associate partner (major customers, technology & service providers) at a representative international level.  Five unmanned UAV platforms (passenger eVTOL, Hydrogen fuel cell VTOL, AED medical drone, X8 medical transport) will be combined with manned aviation in real life exercises validating technology in real urban environment.  Technologies of all partners will be leveraged to make use of the maximum number of U-Space services towards the highest possible operational safety level, including advanced Detect And Avoid U-space service. The demonstrations will take place in the cities of Antwerp (BE), Aachen (DE) and Heerlen (NL), leveraging the MAHHL trans-border region, following a full de-risking exercise at the DronePort BVLOS test-facility in Sint-Truiden, Belgium.  The demonstration results will be further virtually enhanced through large-scale simulations in order to test the maximum airspace capacity of the CONOPS.  The project results will then further be validated and made representable for the whole of the EU, by simulating demonstrations in two additional locations in Europe, namely Athens, Greece (South EU) and Prague, Czech Republic (East EU). Lessons learnt will be documented in a Performance Assessment and recommendations report, providing refinements to the current U-space architecture principles and creating measurable indicators for UAM which will enable Smart Cities to include UAM in their Transport Roadmaps, support standardisation and thereby safety.  Finally, SAFIR-Med will have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'In Silico Trial for Tuberculosis Vaccine Development', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Tuberculosis (TB) one of the world’s deadliest diseases: one third of the world’s population, mostly in developing countries, is infected with TB. But TB is becoming again very dangerous also for developed countries, due to the increased mobility of the world population, and the appearance of several new bacterial strains that are multi-drug resistant (MDR). There is now a growing awareness that TB can be effectively fought only working globally, starting from countries like India, where the infection is endemic. Once a person present the active disease, the most critical issue is the current duration of the therapy, because of the high costs it involved, the increased chances of non-compliance (which increase the probability of developing an MDR strain), and the time the patient is still infectious to others.  One exciting possibility to shorten the duration of the therapy are new host-reaction therapies (HRT) as a coadjuvant of the antibiotic therapy.  The endpoints in the clinical trials for HRTs are time to inactivation, and incidence of recurrence.  While for the first it is in some cases possible to have a statistically powered evidence for efficacy in a phase II clinical trial, recurrence almost always require a phase III clinical trial with thousands of patients involved, and huge costs. In the STriTuVaD project we will extend our Universal Immune System Simulator to include all relevant determinants of such clinical trial, establish its predictive accuracy against the individual patients recruited in the trial, use it to generate virtual patients and predict their response to the HRT being tested, and combine them to the observations made on physical patients using a new in silico-augmented clinical trial approach that uses a Bayesian adaptive design. This appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The interface between risk management systems, corporate governance and internal control: implications for EU competitiveness' (RMGIC) under Sixth Framework.

assistant: **Objectives**

In 2005, a Federation des Experts Comptables Européens (FEE) discussion paper concluded that there is an overall need for more research and learning from experience to direct developments in risk management and internal control" (FEE, 2005). The proposed series of four linked conferences on risk management systems, governance and internal control is a direct response to this call and addresses key issues that are central to the achievement of the Lisbon strategy's objective of making the EU the world's most dynamic knowledge-based economy by 2010. It will initiate a unique European interdisciplinary and coordinated research approach, and provide an exceptional training ground for the next generation of academic researchers, regulators and practitioners. From a European perspective, the need for additional research arises from a requirement for a common European language in risk management and internal control to assist in achieving the market efficiency, company competitiveness and integration that are central to the Lisbon strategy.Educationally, a cross- disciplinary approach is essential because modern risk management has its roots in a number of unrelated disciplines, with the result that academic research into risk is discipline specific, and engenders little or no complementary learning. The conferences will bring academics from financial economics, mathematical finance, accounting and audit together with industry experts to create a unique and distinctive cross-disciplinary network in risk, governance and control. The conferences and web-assisted network will ensure progress towards the European Research area, and dissemination of knowledge of good practice that will aid both national and international policy making."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Language of the Arts in Italy between the Middle Ages and the Renaissance. The re-editing of documents from the Milanesi corpus and the compiling of a Dictionary of Historical-Artistic Italian' (ITALART).

assistant: **Concept**

ITALART is a project for the creation of an Italian historical dictionary of the arts and architecture between the Middle Ages and the Renaissance. As sources for the compilation it uses documents of a practical nature produced within the context of art workshops and architectural sites: contracts, surveys, payment notes, letters, corporation statutes, technical instruction manuals, etc. It is mainly these types of documents, providing examples of everyday use of language, otherwise unobtainable, which provide valuable information on the use and spread of a technical language in Vulgar Italian during the period under consideration.An important documental contribution can be found in the two XIX anthologies on historical-artistic topics: ""Documenti per la storia dell’arte senese"" (Siena, Porri, 3 voll., 1854-1856) and ""La scrittura di artisti italiani (secoli XIV-XVII)"" (Firenze, presso l’Editore Carlo Pini, 1876), published by Gaetano Milanesi (1813-1895), a scholar from Siena.Numerous unedited materials left unused in various archives found in Tuscany and several cities in central Italy will be added to the already edited materials contained in these anthologies. These materials, however, will need to be re-edited according to modern philological criteria.The completed dictionary will be produced both in a paper and digital version, the latter published online on a dedicated website. The text corpus, digitised in its entirety and fully searchable, will also be published on the same site. Along with each transcribed text of the corpus there will be a scanned reproduction of the original document, a codicological record, and a set of philological notes, as well as brief annotations for further historical and artistic study.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multidisciplinary Institute of Ageing - Portugal' (MIA-Portugal).

assistant: **Innovation**

The present Teaming second phase application will create the first Centre of Excellence in Ageing Research in Southern Europe and in a R&D low-performing EU member state, to reduce disparities and to bridge the gap between fundamental research and its translation into human intervention. The new Centre of Excellence, the Multidisciplinary Institute of Ageing (MIA-Portugal), will be a new Strategic Research Institute with the University of Coimbra as the core scientific element of a new living laboratory, Ageing@Coimbra’.The overall objective of the new Centre of Excellence is to improve health and wellbeing of an ageing population and benefit from excellence science and innovation potential to deliver business opportunities. Based on an international forefront position in Biology of Ageing, it will create knowledge to promote healthy living, develop, validate and deliver interventions that improve human healthy life expectancy, with a specific focus on those members of both genders of the population with the lowest healthy life expectancy, and promote innovation transfer into practices and services. This will contribute to reduce the socioeconomic burden of chronic diseases and inadequate ageing of population and will foster functional independence, stimulate the economy and raise new high-qualified jobs.MIA-Portugal will be a stepping-stone and sustainable flagship project of the Centro Region of Portugal. The direct investment of MIA-Portugal mounts to >50 million euros. MIA-Portugal is a teaming partnership between the University of Coimbra (UC) (partner in a low R&D-performing country) and the University of Newcastle (UNEW) plus the University Medical Center Groningen (UMCG) (partners in high R&D-performing countries), with strong support from a Technology Park (IPN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Environmental risk assessment of four pharmaceutical compounds employing genomic tools and the seabream, Sparus aurata'.

assistant: **Innovation**

Human and veterinary pharmaceutical drugs are more and more consumed worldwide. Their detection in the environment and their bioactivity has now raised concern for potential adverse effects on non-target species. Notwithstanding recent attention for their environmental presence, there are significant research gaps for existing pharmaceuticals with regard to their potential ecological consequences. In this study, the four most abundantly used pharmaceuticals: Acetaminophen, Carbamazepine, Trimethoprim y Atenolol, will be examined for their long term effect on the genomic and proteomic expression of the gilthead seabream, Sparus aurata. These endpoints provide useful information on the xenobiotic-induced impairment resulting in the activation and silencing of specific genes by elucidating the underlying molecular mechanisms of higher level damage. Gene expression and protein products will be evaluated in liver and brain as target tissues by microarray and 2D differential gel electrophoresis (2D DIGE) techniques, and significantly up and down regulated proteins will be identified by liquid chromatography–tandem mass spectrometry (LC–MS–MS). These responses will be compared with the histopathological effects observed by histomorphological and histochemical techniques to link the toxic responses at different organizational levels. Together with already available toxicity data for this species and the chosen pharmaceutical compounds, we aim to elucidate toxicity mechanisms at molecular level that are linked with effects at higher organizational level. This will help to improve extrapolation techniques from laboratory tests to derive potential ecosystem effects. Also, the knowledge of molecular pathways and proteins involved in toxic processes forms the base for the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deep exploration BoostEd by Advanced exploration Technologies', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project consortium of DeepBEAT aims to develop ground-breaking technologies to use geochemistry for the detection of deep-seated land deposits. Transforming Europe's exploration sector by integrating cutting-edge technologies and sustainable practices will push Europe towards a climate-neutral and socially responsible economy. The exploration of deep land deposits should employ environmentally friendly, socially acceptable, and ultra-low impact methodologies to ensure the citizens that exploration activities can be conducted responsibly. Acceptance to exploration and mining will be a cornerstone towards cultivating a more resilient and inclusive European society.DeepBEAT final outcome will be a workflow which addresses these aspects by two means: I) DeepBEAT plans to engage with the local communities at the test sites to learn about concerns, hesitancy and what is the emotional core of these. Experiences from these events will be included in exploration workflow as an integral part, following the principles of free, prior, informed consent, which requires to interact with communities at a very early stage. II) DeepBEAT proposes ten novel technological developments, all designed to minimize impact on environment and maximise sustainability. These research and innovation developements have the potential to push the limits of surface geochemical exploration to an other level. They comprise a) new insights to ultra-high resolution analytical chemistry, b) increasing sampling strategy efficiency, c) introducing ground-breaking new concepts of dealing with elemental measurement data, d) reducing exploration costs by sample selection, e) testing novel phyto-geochemical media, and f) introducing UAV assisted biogeochemical sampling. Detailed understanding of the deposits co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Lubricant impregnated slippery surfaces' (LubISS) targeting Horizon 2020.

assistant: **Abstract**

LubISS, Lubricant Impregnated Slippery Surfaces, is the first European Training Network with the main objectives of designing, characterizing, and modelling low adhesive easy-to-clean surfaces for anti-icing and anti-fouling. In a coordinated effort among 9 world-class academic institutions and industrial partners from 6 European countries (Finland, France, Germany, Great Britain, Netherlands, Switzerland), advanced lubricant impregnated surfaces will be developed.  Drawing upon the distinguished expertise within the consortium, textured surfaces impregnated with a lubricating liquid or gel will be designed and fabricated through modern experimental preparation, multi-scale characterization methods, and high power simulation tools. With these broad capabilities, the LubISS network offers a unique training platform for Early Stage Researchers (ESRs)  in a multidisciplinary research endeavor of great technological, industrial and environmental importance. The recently introduced concept of lubricant impregnated surfaces is a promising approach to reduce the adhesion of ice as well as biofilm-forming bacteria-to-surfaces. To achieve societal impact, understanding the intimate relationships between the impregnating lubricant, the surface topography, and the adhesion of ice, bacteria, or other biofouling microorganisms is critical.  The general aim of this ITN is two-fold: 1) to establish a fundamental understanding between these relationships through academic and industrial collaborations in physics, chemistry, biomedicine, materials science and engineering, and 2) to educate and train young researchers in this vital area of technology. The LubISS network will investigate many aspects of lubricant impregnated surfaces, including the optimization of the lubricant stability u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Spatiotemporal evolution of the hydrological cycle throughout the European continent during past abrupt climate changes'.

assistant: **Concept**

With global temperatures on the rise due to anthropogenic greenhouse gas emissions, one of the largest short-term threats to societies comes from a changing water cycle: changing ocean currents and atmospheric circulation patterns, increased periods of drought or extreme precipitation events directly affect the socio-economic foundation of communities. However, one of the great unknowns in state-of-the art climate models predicting future changes is the spatial distribution of changing precipitation patterns. This lack of knowledge severely limits implementation of mitigation and adaptation options to divert the most severe consequences of climate change.I propose a fundamentally new approach to understand spatial patterns and mechanisms of hydrological changes on the European continent by reconstructing such changes during past abrupt temperature and ocean circulation changes. We will develop an innovative research program integrating ideas and methods from diverse disciplines: organic geochemistry, plant physiology, event stratigraphy and geostatistical data analysis. We will generate quantitative paleohydrological data by developing a dual biomarker approach as a novel and direct proxy for fluxes in the hydrological cycle from 10 of the most precisely dated terrestrial climate records encompassing the European continent.STEEPclim will enter uncharted territory and establish master records of continental climate change, comparable in resolution and quality to the polar ice cores. We will identify continental-scale feedback mechanisms and particularly vulnerable regions in European hydroclimate relevant for the evaluation of the consequences of ongoing climate change. These mechanistic insights will be essential to validate future generations of climate models, ensurin