RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A continental-scale test of the climate hypothesis for the evolution of altruism in insects' (WaspCLIM) under Horizon 2020.

assistant: **Objectives**

This multidisciplinary fellowship will address a key emerging enigma in evolutionary biology: does variation in climate shape the evolution of animal ‘altruism’ (costly cooperation in the service of others)? Recent speculation has suggested that climate influences the power of kin selection (a central mechanism in the evolution of altruism). I will test this hypothesis in four work packages. First, I will provide an analysis of variation in the power of kin selection on an unprecedented latitudinal scale. The African wasp Belonogaster juncea ranges from the equatorial tropics to temperate South Africa, permitting an intraspecific test of the link between climate and altruism. Second, I will conduct extensive behavioural experiments over this latitudinal range to dissect variation in the motivations for cooperation. Third, I will undertake a global comparative analysis of the effects of climate on cooperation in simple eusocial wasps and bees, synthesising decades of published data to parameterise a mathematical model of the evolution of cooperation under different climate regimes. Fourth, I will develop a novel citizen science approach in Sub-Saharan Africa to collect fundamental data on variation in cooperation in wasps, engaging local populations in the practice of ecology at large scales. By providing a multidisciplinary synthesis to test the link between climate and kin selection, WaspCLIM will significantly advance our understanding of the ultimate drivers of altruism – one of the top 25 outstanding scientific questions identified by the journal Science.


**Keywords:** altruism,  evolution of cooperation,  social evolution,  kin selection,  inclusive fitness,  wasps,  eusociality,  climate,  Hamilton's rule,  latitudinal gradients,  social insects,  Hymenoptera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a novel DNA vaccine and identification of an autoantigen relevant to type I diabetes' to be submitted under Sixth Framework.

assistant: **Abstract**

Insulin-dependent diabetes mellitus (IDDM, type I diabetes) is a metabolic autoimmune disease in humans in which the ß cells of the islets of Langerhans are selectively destroyed. To date, no cure has been developed for this disease. While it has been established that the destruction of this tissue predominantly occurs due to auto-reactive recognition by CD4 T cells, the etiology of this disease as well as many of the autoantigens recognized by these T cells, are unknown.Certain major histocompatibility com plex (MHC) class II alleles have been strongly linked with IDDM, such as DQ8 in humans and I-Ag7 in the non-obese diabetic (NOD) mouse, a spontaneous model for type I diabetes. In order to find a cure for IDDM, the target antigens that drive auto-reactive T cell recognition need to be identified and new immunotherapies need to be developed. Therefore, the main objectives of this project are the identification of one of these auto-antigens as well as the development of a novel DNA vaccine. To reach the first objective, several new in silico and in vitro approaches will be used for the identification of antigen candidates, that could possibly be recognized by a well characterized diabetogenic T cell clone called BDC2.5. Recombinant antigens will be generated in order to screen for the activation of BDC2.5.We will finally evaluate the natural T and B cell response against this autoantigen in vivo in the NOD mouse in order to assess the value of protein homologues for the development of new diagnostics for disease prediction in humans. The second objective will be the generation of a novel DNA vaccine coding for soluble I-Ag7/peptide dimers. We will use the BDC2.5 system as a model to explore its efficacy in the NOD mouse. I-Ag7/peptide tetramers will allow us to evaluat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Further development of the film method for modelling membrane protein three-dimensional structures' in the context of a Fifth Framework call.

assistant: **Objectives**

The main objective of our research project consists in deriving an ab initio method able to predict, at an acceptable level of accuracy , folding and topology of membrane proteins. This will be carried out by improving FILM (Folding in Lipid Membranes), a knowledge-based method previously developed to predict 3-D structures of small membrane proteins. With this aim, energy functions able to describe folding and packing interactions inside the membrane will be derived by the approach used in the current version of FILM. A data set composed of macromolecules with known topology and high-resolved 3-D features will be created for each class of membrane proteins. Furthermore, topology,folding and packing will be studied by statistical analysis of each set and converted in interaction energy functions by applying the inverse Boltzmann equation. The novel interaction energies will be added to the earlier force field and the improved method will be validated on proteins having high-resolved 3-D structure available at PDB. Finally, also peptides forming oligomeric channels, such as melittin and alamethicin will be considered and a proper energy functions will be developed, so that the method could be reliably applied to the whole family of membrane proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exact Results from Broken Symmetries', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Symmetries serve as our main guide in studying physical phenomena. The more symmetric a system is, the more constrained are its degrees of freedom and the better prospects we have to understand and solve it. Significant progress has been achieved in the study of theories with high amounts of symmetry in the last decades. Supersymmetry and conformal invariance are the main reasons why the beautiful idea of holography materialised into the AdS/CFT correspondence and the discovery of hidden symmetries (integrability) in gauge theories was possible. Thanks to supersymmetry, modern mathematical techniques allowed the evaluation of the otherwise unfathomable path integral and the comprehensive study of a long list of physical observables. Finally, the successful revival of the conformal Bootstrap program is based on conformal invariance. These breakthroughs are, unfortunately, applicable only to theories with unrealistic amounts of symmetry. BrokenSymmetries will break this impasse by applying the aforementioned ideas to more realistic theories, where some of the supersymmetry and/or conformal invariance are broken. The key innovation of BrokenSymmetries is to still make use of a broken symmetry. Symmetries are captured by Ward identities which we can still derive in various cases of symmetry breaking. Broken symmetries also imply powerful non-perturbative relations that observables obey. We will combine these with the developments mentioned above, producing novel exact results.  Our approach will give a handle on otherwise insoluble problems. The objectives of BrokenSymmetries are to obtain exact results while breaking:1) conformal invariance spontaneously, keeping supersymmetry intact;2) supersymmetry explicitly, keeping conformal invariance intact;3) both supersymmetry and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Safe maritime operations under extreme conditions: the Arctic case' (SEDNA) targeting Horizon 2020.

assistant: **Abstract**

Maritime traffic in the Arctic region is rapidly increasing. But there has been a huge increase in marine casualties in this region due to its extremely harsh environment and the severe safety challenges for ships’ navigation teams.SEDNA will develop an innovative and integrated risk-based approach to safe Arctic navigation, ship design and operation, to enable European maritime interests to confidently fully embrace the Arctic’s significant and growing shipping opportunities, while safeguarding its natural environment.More specifically SEDNA will create and demonstrate the improved safety outcomes of: 1. The Safe Arctic Bridge, a human-centered operational environment for the ice-going ship bridge using augmented reality technology to provide improved situational awareness and decision making whilst enabling integration with new key information layers developed by the project using innovative big data management techniques.      2. Integrated dynamic meteorological and oceanographic data with real time ship monitoring and ice movement predictions to provide reliable decision making for safe and efficient Arctic voyage optimisation.3. Anti-icing engineering solutions, using nature inspired approaches, to prevent ice formation on vessels, eliminating ice as a ship stability and working-environment hazard.4. Risk-based design framework to ensure that vessel design is connected to all key hazards of ship operation in the Arctic. The holistic treatment of the ship design, operating regime and environment will improve safety and minimise impact over the entire life cycle.  5. A CEN Workshop Agreement on a process to systematically address safety during bunkering of methanol as a marine fuel along with safety zone guidance for three bunkering concepts: Truck to Ship, Shore to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Articulations of Desire: Populism and the Future of Democracy' (AoD).

assistant: **Innovation**

This project argues for a coherent concept of political desire as a necessary step toward understanding the limitations of democratic institutions. As democracies around the world react to unprecedented challenges, distrust of the various national and supranational institutions presiding over North American and European democracy has risen sharply. This skepticism has led to unstable political conditions and an agitated populace. The uncertain future of democratic institutions is magnified by populist resurgences that challenge existing norms and defy conventional political wisdom. A mounting concern to philosophers and political scientists alike, populism has been identified as a significant result – and sometimes source – of political turmoil. However, an understanding of precisely how and why these movements arise and gain traction has not been given due attention from a broader philosophical position. “Articulations of Desire” (AoD) contends that there is more at stake in populism than unrest, demagoguery, and mob rule. Seen through a lenses of order and disorder, rationality and irrationality, populism is thought to be the chaotic and ungovernable whims of the masses.  However, this project approaches populism as the eruption of repressed collective desire. This project assert that unresponsiveness to desire often does jeopardize democratic processes, but precisely because it delegitimizes institutional claims to sovereign democratic authority. Here, desire can be defined as a positive vector of expression and demand that is a foundational force of collectivity. By developing a concept of political desire and examining the nature of populism, this project seeks a new understanding of democratic collectivity that challenges dominant Liberal models. By developing thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Decoding the Epigenomic Regulatory Code by the Use of Single Cell Technologies' (SC-EpiCode) under Horizon 2020.

assistant: **Objectives**

Chromatin regulators adjust genome functions by modifying chromatin states. Comprehensive characterization of chromatin states, associations of chromatin regulators, and expression profiles is crucial for investigating: 1.Cellular differentiation triggers. 2.The nature of the underlying chromatin regulatory mechanisms. 3.The effect of cellular heterogeneity, and 4. How chromatin affects mRNA expression. Mapping chromatin states by sequencing immunoprecipitated chromatin (ChIP-seq) provides an extraordinary resource for studying cellular states. However, a major shortcoming is that the profiles reflect a composite average over the studied cell population, concealing important information about the underlying subpopulations. To address this hurdle, I pioneered Drop-Seq, a novel drop based microfluidic technology for single cell ChIP-seq and RNA-seq. Applying the technique to thousands of embryonic stem (ES) cells, we identified a spectrum of sub-populations defined by differences in chromatin signatures of pluripotency and differentiation priming. However, despite initial progress, the extent and significance of chromatin-state heterogeneity and its relationship with mRNA expression remain largely uncharted. The central aim of this proposal is to develop a novel framework to systematically characterize cell-to-cell variability at the epigenomic level. Our approach will include the development of technology enabling ChIP-seq and RNA-seq on the same cell. We will also exploit drop-based microfluidics to develop a robust CRISPR/Cas9-based approach to assess single and multiple perturbations. Finally, we will apply these innovative technologies to questions about cellular heterogeneity and epigenomic regulation during early differentiation of ES cells. This proposal will reve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Learning and memory, immediate-early genes and cell adhesion molecules - a search for the missing links' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The formation of long-term memory is assumed to depend on the synthesis of new molecules or modifications of pre-existing ones, which contribute to more or less permanent functional changes in synaptic connections, thus shaping preferred pathways as the neural substrate of memory trace. The molecular mecanisms involved in triggering the synthesis of learning and memory related molecules are reported to involve the initial activation of c-fos and c-jun, and numerous data exist about the possible involvement of these two proto-oncogenes in learning and memory. Cell adhesion molecules have also been implicated in learning and memory in different studies, and results obtained support the view that neural adhesion molecules, and in particular N-CAM and L1, may play important roles in stabilisation of memory traces. The aim of my work could be to determine in different models of transgenic mice, using immunocytochemistry and in situ hybridization, if there is a link between c-fos/c-jun expression and N-CAM/Ll functions and synthesis in learning conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bacterial Cellulose (and)- based Skin Repair material - BC' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Burn injury is a common type of traumatic injury, causing considerable morbidity and mortality. Moreover, burns are also among the most expensive traumatic injuries, because of long hospitalization and rehabilitation, and costly wound and scar treatment.  Worldwide, an estimated 6 million patients seek medical help for burns annually, but the majority are treated in outpatient clinics.   According to World Health Organisation, estimated burn management costs in 2017 were 10.5 billion EUR.  The removal of traditional dressing material can adhere to desiccated wound surfaces and induce trauma followed by life-threatening infectious contamination. The treatment time is long and complicated. Recovery process of skin, that often-become life threatening, if complicated by infectious contamination, is always highly dangerous in case of large burn injuries. Project team has conducted experimental research and patented an efficient   nanostructured cellulose-producing strain. It has been characterized by increased rate of Bacterial Cellulose (BC) production, also by high cellulose yield from the consumed Csubstrate. Both parameters, also facilities of application of a cheap raw material, for bacteria growth and BC synthesis is an essential advantage of the strain to increase   cellulose production per unit of time   and space (surface area of fermentation vessels) and to reduce expenses associated with cellulose production. In general, the main innovation of the process is due to the high productivity of BC process achieved through the use of a unique patented producer-strains and bio-technological approaches, as well the modification of BC with bio-active substances with custom target activity. Thanks to the unique properties of BC material, project aims to introduce BC SKIN pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Re-engineering of audio-visual productions through distributed co-operative development' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objective is to improve the business processes in audiovisual SMEs by integrating a platform for the distributed cooperative development of audiovisual productions, enabling close collaboration between customer, producer and subcontractors.The re-engineering of the business processes will trigger the use of the platform leading to:1. Streamlining" of audiovisual productions due to elimination of redundant operations, quality and work flow improvement.2. Reduce production costs by up to 50% due to reductions in: labour cost, information cost, materials cost, administrative cost, cost of money.3. Reduce development time by up to 30%: the continuous collaboration between customer, producer and subcontractor will lead to a considerably faster refinement of the storyboard, quicker completion of the production preparation and post production phases.4. Improve customer orientation while making the rationale behind the production more transparent: the step-by-step collaboration will allow the customer to more accurately to determine the desired outcome and will lead to faster response to his changing needs.5. Decentralisation of production: the possibility of cooperating closely with distant subcontractors will help the producer company to increase quality while operating in a more cost effective way. 6. Re-use of assets: Given that the project will be based on electronic databases for multimedia assets, the latter will be available for future use.7. Development of human resources and improved job satisfactionThe project consists of three main phases:1. During the first phase, an exact formulation and validation of the business objectives of the users and the identification of the scope of the BPR will be developed. The results will be available in the 6th month after