RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular mechanisms underlying the evolution of central neural circuits and behaviour' (MolEvoNeu), addressing dissemination and exploitation.

assistant: **Impact**

The immense variety of behaviours displayed by animals – including ourselves- arose through the evolution of neural circuits within the brain. However, how central neuronal circuits change over time, integrating these modifications within the brain's highly interconnected networks remains largely unknown. Particularly puzzling is that evolution acts at the level of the genome but behaviour arises through the activity of neuronal networks. How are these two levels integrated? How do evolutionary changes on the genome lead to changes in neuronal circuits that themselves lead to behavioural divergences across animals? The larval olfactory system of Drosophila provides a powerful model to address these questions because: 1) different Drosophila species have evolved diverse odour-guided behaviours, 2) the olfactory system is numerically simple yet parallels more complex circuits, and 3) the availability of molecular tools and resources. I will use this system to identify hotspots of central neuronal circuit evolution at both functional and genetic levels by comparing two Drosophila species. First, leveraging comparative connectomic data from the host lab, I will use calcium imaging and modelling to examine the functional impact of cross-species connectomic changes. Second, I will employ a combination of transcriptomic approaches to determine the molecular changes that lead to functional and connectivity differences. Finally, I will apply these insights to re-engineer the neuronal circuits across species by making use of the genetic tools available in D. melanogaster. This research will enhance our understanding of the intricate interactions between genes, neuronal circuits, and behaviour in the context of evolution.


**Keywords:** Evolution, central neuronal circuits, brain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Safe Management of Mining Waste and Waste Facilities' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The project aims at supporting the implementation of the Directive 2006/21/EC of the European Parliament and of the Council on the management of waste from the extractive industries and amending Directive 2004/35/EC. The Directive was prepared following several major accidents with a serious impact on the environment, and it has the purpose of ensuring a safer management of the mining waste facilities, so that such accidents will not occur in the future. This project addresses particularly Article 9, which provides for the classification of waste facilities with respect to the possible consequences of an accident, and respectively the Annex II - Waste characterisation and Annex III - Criteria for determining the classification of waste facilities.The activities of the project are divided into four major work packages as follows:- Review of Methods for the Characterisation of Mining Waste- Review of Risk Assessment Methodologies for the Classification of Mining Waste Facilities, including Old/Abandoned Mining Waste Facilities- Review of Techniques for the Prevention and Abatement of Pollution Generated by Mining Wastes- Development of a Decision Support Tool for Minimising the Impact of the Mining Industry on the Environment.The Consortium co-ordinated by BIUTEC, Austria, includes universities, research institutes, NGOs, private enterprises and implementing authorities from 8 European countries, both Members of the EU and Accession Countries.The experts' team is highly qualified and has many years of experience and research in this area, so that the best outputs can be obtained. The project will build on the results of other projects carried out in this field, and will relate closely to on-going projects, so that there is no overlap in our activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FocusLocus: ADHD management Gaming System for educational achievement and social inclusion', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Attention Deficit Hyperactivity Disorder (ADHD) affects a significant part of the population and causes considerable behavioural problems, learning limitations in the context of the formal education system and increased chances for social exclusion. Current treatment approaches induce high costs to welfare systems and individuals, while the widespread usage of stimulant medication remains a subject of controversy due to undesirable side-effects. FocusLocus brings together a multidisciplinary Consortium of partners aiming to design and produce market-oriented products and services for ADHD management by leveraging knowledge and technology from previous research and innovation activities. FocusLocus proposes a highly disruptive and innovative game-based intervention, relying on agent-based game mechanics that incorporate learning schemes for mental and motor skill acquisition and behavioural change, adopting multisensory user interaction, featuring personalisation, adaptation, performance analytics and monitoring features, delivered in a dual User Experience (UX) mode. Even though FocusLocus will be designed, tested and evaluated specifically for the case of ADHD management, it is expected that it will also be beneficial to a number of other associated mental, psychological and cognitive disorders and learning disabilities, thus generating a substantial marketing potential. FocusLocus activities will include the deployment of a pilot study for the extensive assessment of the proposed gaming system, the generation of evidence regarding its performance, the documentation of results for further ADHD research purposes and the creation of solid foundations for a marketable product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FLUORINATED SUGARS: CHEMICAL TOOLS FOR THE STUDY OF CARBOHYDRATE-BINDING PROTEINS' under Seventh Framework.

assistant: **Concept**

This project focuses on the preparation of potentially biologically active fluorinated glycoconjugates (mainly lipids, amino acids, peptides and eventually proteins) and also to explore the biological and biophysical properties of these molecules in vitro and in living cells that are decorated with these unnatural fluorinated elements on their surfaces. For this purpose, the project will first focus on the preparation of a range of fluorinated carbohydrates and lipids with configurations related to those recognized by lectins. The synthesis of fluorinated carbohydrates and lipids will be carried out using already established procedures and by developing new procedures based on carbohydrate chemistry or asymmetric synthesis. The next step will consist of attaching the prepared fluorinated materials to the corresponding aglycons, amino acids, peptides or proteins (in the case of F-carbohydrates) or to the corresponding sugars in the case of F-lipids. In the second part of the project, the conformation of these F-glycoconjugates will be studied using leading spectroscopic techniques (mainly 19F STD-NMR, X-ray, etc.). This will provide valuable information on how these molecules might interact with target proteins and receptors. Next, those constructs with most interesting properties will be employed for proteomic analysis as multifunctional affinity-based probes, to screen, detect and isolate carbohydrate-binding proteins with/without enzymatic activity. Finally, the sensitivity and the absence of a F background signal in 19F NMR will be used to study the metabolic profile of those F-glycoconjugates (by 19F NMR) and establish correlations between alteration of biosynthetic pathways, biodistribution, metabolite concentrations, immune response and disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SensUS: A non-invasive and quantitative ultrasound (QUS) device for an objective monitoring of the childbirth labour process.' to be submitted under Horizon 2020.

assistant: **Abstract**

Today the obstetrics sector is registering an increase in the C-Sections (CS) performed worldwide. Over 50% of CS are unnecessary, placing mother & baby under unnecessary risk. Unnecessary CS cause an extra cost of €750 million per year to the healthcare system in Europe. Although the WHO recommends not to exceed a rate of 15% of CS, Europe alone shows a rate of 29%. Most of the extra CS performed are due to errors during the monitoring of labour events. The few ultrasound devices available to monitor the labour timeline provide qualitative subjective information, depend on the operator skills, and some involve invasive procedures. Thus, new solutions are needed to help doctors take better informed decisions. In response to this need, we at AMOLAB have developed, patented and validated SensUS, a unique ultrasound device for quantitative & objective monitoring of childbirth events. This device contains our proprietary software, which measures selected validated parameters of the labour process. SensUS offers doctors objective details to support and guide their decisions during childbirth monitoring. In turn, it will allow to assign CS only to those cases that need it, reducing risks, costs and enhancing healthcare quality. After validating the reliability of SensUS on over 400 labours, we now want to take SensUS to market maturity. This project aims to finalise its technological development and secure its commercial aspects. To accomplish these goals, in Phase 1 we aim to evaluate the main milestones of the project from a technical, commercial and financial point of view, and prepare the most suitable strategy to achieve them. Once the project is completed and SensUS reaches the market, our technology will bring significant benefits to the obstetrics sector, as well as f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Helicopter Electric Regenerative Rotor Brake' (HERRB), addressing dissemination and exploitation.

assistant: **Impact**

The proposal outlines a design process coupled with a full evaluation and testing phase for a fully electric replacement for the current mechanical-hydraulic rotor brake system that exists on most large rotorcraft in production currently allow regenerative capture of the inertial energy stored in the aircraft drivetrain during deceleration.The concept offers further potential alongside other similar projects to downsize and in the long term even remove the hydraulic circuit that exists on aircraft resulting such that the benefits of electrical systems becomes significant.  Furthermore, once on the aircraft, installation of the equipment provides potential for several performance and system benefits as there would exist coupled to the rotor a bi-directional power flow controller within an independent energy store.  Possible systems would include fast rotor start, auto-gyro assist for safe landing in the event of primary power failure and extra power on-board electrical power generation for redundancy during flight.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Prosaposin and GPR37 in synucleinopathies' (PROGSY) targeting Horizon 2020.

assistant: **Abstract**

The next breakthrough in the treatment of synucleinopathies, incl Parkinson´s disease (PD), will be aimed at interference of disease progression based on insights into the underlying pathogenic process. The pathological hallmark of PD are Lewy bodies (LBs), in which α-synuclein is the major constituent together with other PD-linked gene products (DJ-1, LRRK2, parkin, and GBA) and aggregated GPR37. GPR37 is exceptional among GPCRs having a high propensity for intracellular receptor accumulation and aggregation leading to neurotoxicity. However, unexpectedly, our results suggest that GPR37 is neuroprotective in dopaminergic when located at the plasma membrane. Consistently, prosaposin (PSAP), and its neurotrophic fragment prosaptide, were recently identified as agonists at GPR37. PSAP is a neuroprotective protein that regulates intracellular lysosomal enzyme function, with saposin C being a co-factor of GBA. In addition, we hypothesize that PSAP is secreted following cellular stress and, via membraneous GPR37, cue dopamine neurons to initiate survival pathways. Pivotal to this programme is modeling and analysis of the atomic structures of GPR37 in complex with prosaptide, which will grossly facilitate mechanistic understanding and drug development with potential use in diagnosis and treatment. Novel applications and technological advancements of fluorescence correlation spectroscopy will be implemented for single molecule trafficking of GPR37 and its ligands and will examine whether GPCR multimerization beyond dimer formation may be neurotoxic. Normal and cGPR37KO mice will be virally transduced by α-synuclein to delineate in the relative contributions of improved lysosomal function versus GPR37 agonism for neuroprotection by prosaptides. Evolving from the autopsy studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Application of Assembly Line Synthesis to The Construction of Biologically Active Molecules'.

assistant: **Concept**

This proposal seeks to develop a new strategy for chemical synthesis which we term “Assembly Line Synthesis”. Our plan is to develop new reactions and strategies which enable us to essentially grow a carbon chain with complete control over its shape (stereochemistry) and functionality (which groups are incorporated) in a single operation.  Our unique methodology involves the reaction between a lithiated carbamate and a boronic ester to give the homologated product. This chemistry can be done in an iterative manner, without the need for purification between steps, enabling complex molecules to be created with complete control of both relative and absolute stereochemistry. To date we have done 7 homologations in one pot with full stereocontrol. Indeed, through choosing the approriate stereochemistry of substituents along a carbon chain, we have grown a molecule which adopts a linear conformation. We are interested in the further development of the homologation of boronic ester methodology and its application in the synthesis of chemically and biologically useful molecules.We now plan to apply this methodology to the synthesis of the hydroxyl phthioceranic acid, a potent antigen that stimulates the immune response towards tuberculosis. We expect to make this molecule in just 2-3 discrete operations, a far cry from the 30+ steps taken in the past. In collaboration with Prof. Wender at Stanford, we also plan to prepare improved transporters to carry lipophilic drug molecules (like the potent anti-cancer compound taxol) into cells. We will use our iterative methodology to create lipophilic carbon chains bearing polar guanidinium rich side arms with specific shape and improved transporter properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Overcoming challenges in the evolution and nature of massive stars' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Massive stars are the cornerstone of the dynamic and chemical evolution of the cosmos, enriching it as they evolve with chemically processed material that is blown away from their surface by energetic winds and eruption processes. Despite their importance, their evolution from cradle to death as spectacular supernova explosions still poses many mysteries due to crucial knowledge gaps in the physical processes taking place in their interior and atmosphere and the mutual influence by close-by siblings. Our ultimate goal is to elucidate the physical properties and evolution of massive stars impacted by companions, as well as their contribution to the generation of gravitational waves. For this, we wish to establish a multidisciplinary, international network of researchers from Europe and America with expertise in various disciplines, and with background in both theory and observations. We will exploit the avalanche of public data archives and develop machine learning algorithms to detect massive stars in binary and multiple systems, classify them, and create statistically meaningful samples for diverse evolutionary states. We will develop progressive methods of signal processing for the analysis of the stellar properties, and cutting-edge numerical codes to unveil the impact of stellar interaction and mass ejection on the evolution of the stars and stellar systems. The acquired results will significantly enhance our knowledge and lead to major advancements in all related fields. The bulk of exchanges will be undertaken by PhD students and Postdocs, whom we will educate and train in modern observing and data analysing techniques, machine learning algorithms, and in high-performance computing, equipping them with excellent skills for their future careers. We will organise sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'EXtreme Tectonics and Rapid Erosion in Mountain Environments'.

assistant: **Objectives**

Tectonic plate corners are hotspots for high rates of continental deformation and erosion, and associated with human-relevant hazards including poorly understood earthquakes, destructive landslides, and extreme climate. A better understanding of continental deformation can mitigate these hazards. However, the coupling between climate and tectonic interactions at plate corners is a key unknown and the focus of this study. My recent work, published in international journals including Science and Nature, quantifies mountain building and climate change and provides a baseline for an innovative study of plate corner dynamics.This proposal challenges the geoscience ‘tectonic aneurysm’ paradigm that rapid deformation and erosion at plate corners is initiated from the “top down” by localized precipitation, and erosion. Rather, I hypothesize that these processes are: 1) initiated from the “bottom up” by the 3D geometry of the subducting plate; and 2) require a threshold rate of both “bottom up” deformation and surface erosion to initiate a feedback between climate and tectonics.I propose, for the first time, a holistic modeling and data collection approach that quantifies the temporal and spatial evolution of all aspects of plate corner evolution, including: 3D thermomechanical modeling of plate corner deformation and uplift for different plate geometries; Atmospheric modeling to quantify the climate response to evolving topography, a topic spearheaded by my research group; And surface process modeling to close the loop and couple the atmospheric and mechanical models. Model predictions will be vetted against observed deformation and erosion histories from existing and new cosmogenic isotope and thermochronometer data from end-member locations including the Himalaya, Alaskan, Ol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fundamental Problems at the Interface of Combinatorial Optimization with Integer Programming and Online Optimization'.

assistant: **Objectives**

The goal of this proposal is to leverage and significantly extend techniques from the field of Combinatorial Optimization to  address some fundamental open algorithmic questions in other, related areas, namely Integer Programming and Online Optimization. More precisely, we focus on the following three thrusts, which share many combinatorial features:- Integer programming with bounded subdeterminants.- Expressive power of mixed-integer linear formulations.- The matroid secretary conjecture, a key online selection problem.Recent significant progress, in which the PI played a central role, combined with new ideas, give hope to obtain breakthrough results in these fields. Many of the questions we consider are long-standing open problems in their respective area, and any progress is thus likely to be a significant contribution to Mathematical Optimization and Theoretical Computer Science. However, equally importantly, if progress can be achieved through the suggested methodologies, then this would create intriguing new links between different fields, which was a key driver in the selection of the above research thrusts.