RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Ocean Visions: The Impact of Private Oceanographic Vessels and Documentary Making on Ocean Science Governance and Research'.

assistant: **Objectives**

Ocean science is no longer the sole domain of public research institutes and their vessels. Private oceanographic vessels are increasingly able to influence its governance and research practices. The business model of private vessels relies on producing wildlife documentaries that feature telegenic discoveries and charismatic animals, alongside ocean scientists themselves. While their vessels actively enable scientific research, companies like OceanX also ensure the steady production of striking moving images for wildlife documentaries, such as BBC’s Blue Planet. OceanVisions aims to understand how these private vessels affect the daily governance of ocean science research, and specifically how their emphasis on documentary film production shapes ocean scientists’ objectives and routines. By foregrounding practices of visual content production for scientific analysis and documentaries, OceanVisions explores everyday governance arrangements in ocean science and analyses how scientists adapt their knowledge creation practices to the requirements of film-making onboard oceanographic vessels. This research project utilises an innovative research design, conducting a comparative ethnography between one public research vessel, owned by the Royal Netherlands Institute for Sea Research, and one private vessel, owned by OceanX. This interdisciplinary project – which brings together studies on the governance of science with the anthropology of science – will be carried out at the Centre for Science and Technology Studies at Leiden University, a leading institute focusing on scientific research and its connections to technology, innovation, and society. The project will also benefit from a secondment at the Massachusetts Institute of Technology.


**Keywords:** Anthropology of sci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'IMAging GEnetics for MENtal Disorders' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mental disorders are leading causes of disability, absence from work and premature retirement in Europe. While magnetic resonance imaging (MRI) facilities are broadly available and a vast research literature exists, few neuroimaging applications have reached clinical practice in psychiatry. A major problem is that mental illnesses are currently diagnosed as discrete entities defined clinically. Instead, recent results show that mental disorders are best understood as quantitative alterations in neural systems relevant across traditional diagnostic boundaries that reflect individual, genetic and environmental risk factors. In the IMAGEMEND consortium, we aim to discover these systems to identify the patient characteristics most relevant for treatment, derive biomarkers and decision rules from this systems-level dimensional account, and systematically validate biomarker panels in patient, high-risk and epidemiological samples to produce automated imaging-based diagnostic and predictive tests tailored for wide distribution throughout Europe in standard clinical settings. Focusing on schizophrenia, bipolar disorder and attention deficit-hyperactivity disorder, we have assembled Europe’s largest dataset combining neuroimaging, genetic, environmental, cognitive and clinical information on approximately 13000 participants, and have recruited international replication datasets of more than 30000 people. This unique resource will be processed using a new generation of multivariate statistical analysis to optimize existing imaging technology for the benefit of patients. We will also develop new imaging technology to enable the direct imaging-based therapeutic modification of neural circuits through rapid real-time MRI. Our deliverables will promote personalized treatment through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pi-Conjugated Porphyrin Nanorings' (Nanoring) under Seventh Framework.

assistant: **Objectives**

This project will explore the synthesis and properties of fully pi-conjugated molecular nanorings with diameters of 3-5 nm. These covalent rings of molecular wire will be constructed from porphyrin and alkyne units, via non-covalent supramolecular assembly on wheel-shaped templates. Their highly delocalized electronic structures are expected to result in unusual optical and magnetic behavior. The photophysical and light-harvesting behavior of the nanorings are expected to mimic natural light-harvesting photosynthetic chlorophyll arrays. Physicists have long been fascinated by the persistent ring-currents and quantized magnetization observed in small loops of wire; it is important to discover whether similar effects can be observed in molecular nanorings. The synthesis of these wire rings could herald the development of molecular solenoids and induction coils with unusual optical and magnetic characteristics, leading to applications in nanoelectronics and nonlinear optics. This project will extend the researcher's experience of organic synthesis, large delocalized chromophores and near-infrared dyes, while introducing him to the latest developments in template-directed synthesis, ESR spectroscopy and ultra-fast photophysics through established collaborations involving the host research group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mapping Cytokine Signalling Networks using Engineered Surrogate Ligands' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Cells use an intricate network of intracellular signalling molecules to translate environmental changes, sensed via surface receptors, into cellular responses. Despite their prominent role in regulating every aspect of life, we lack a comprehensive understanding of how signalling networks convey extracellular information into specific bioactivities and fate decisions. To rationally manipulate cell fate, which could fundamentally change the way that we treat human diseases, first we need a systematic understanding of how signalling is initiated and propagated inside the cell. I discovered that specificity of cytokine receptor signalling not only depends on cellular determinants such as receptor density and endocytic trafficking, but can be systematically altered by modulating ligand binding parameters and receptor binding geometries. A fundamentally novel approach combining high-throughput flow cytometry and QMS with engineered cytokine surrogate ligands able to fine-tune signalling responses will generate detailed maps of the signalling networks engaged by cytokines in time and space to unveil the mechanistic basis that allow a receptor to trigger different signal activation programs and bioactivities in response to different ligands. By quantitatively characterizing the signalling programs activated by ligands, using state-of-the-art biochemical, biophysical, structural, genetic and fluorescence imaging techniques, I plan to identify events critical for cellular decisions. By fully characterizing the intracellular signalling network hard-wired inside a cell and understanding its dynamic in response to environmental changes will we be able to comprehend and manipulate the enormous functional plasticity exhibited by cells. TInsights generated will open new fields of inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European maritime data management' (EMDM) targeting Sixth Framework.

assistant: **Abstract**

Face to the challenge of the intermodal, safe and secure European transport development, the EMDM project aims to study and develop new applications, functionalities and proposals for specifications and standards for enhanced, interactive VDRs and electronic logbooks. The EMDM project will lead to a better and more objective analysis of the causes of incidents and accidents in European waters and subsequently to the improvement of maritime safety.This will be done through studies of the needs of the maritime community, discussion of a high level group of stakeholders, including most of the member states and equipment manufacturers, conducing to the deliveries of draft standards on VDRs and Electronic logbook (WP1 and WP2). Specific studies on potential use of electronic logbooks, assessment of VDRs application for automatic control, development of new concept obtained from exploitation of the registered VDRs data will be realised in WP3.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Support for European aeronautical SMEs - phase V'.

assistant: **Innovation**

AeroSME V will provide continued European wide support for aeronautic SMEs in surviving in a rapidly changing global market, and encouraging participation in ED R&TD projects, which will develop much needed pan-European co-operation in the Aeronautics supply chain. AeroSME V is supported by AECMA, the European Association of Aerospace Industries representing the aerospace industry in Europe in all matters of common interest. Due to the privileged communication channels with large companies (represented in the Industrial Management Groups - IMG3), research establishments, Universities, National and Regional Associations, the project will provide a proactive interface between SMEs and aeronautics related bodies and will represent a point of reference for S ME issues. The coverage of all the countries associated with FP6, including the Associated Candidate Countries, will ensure a truly pan-European approach. Building on the previous experience, AeroSME V will strengthen and improve the support and guidance c ontinuously needed to increase the SME participation in ED R&TD Programmes. Through tailored services such as the Helpdesk, the website, the SME database and the Newsletters, the project will continue to improve the communication within the Aerospace I ndustry and provide SMEs with information and individual consulting support needed. Specific actions will be undertaken in co¬ operation with IMG3 to facilitate the integration of SMEs in IPs and the set up of SME-led STREPs. Workshops addressed to aeronau tic SMEs will be organised to raise awareness on European research issues and Industry's future needs, as well as to facilitate contacts with large companies in the supply chain. A very pro-active approach will be applied in the Associated Candidate Countr ies. Finall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bio-inspired Spin-Torque Computing Architectures', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the bioSPINspired project, I propose to use my experience and skills in spintronics, non-linear dynamics and neuromorphic nanodevices to realize bio-inspired spin torque computing architectures. I will develop a bottom-up approach to build spintronic data processing systems that perform low power ‘cognitive’ tasks on-chip and could ultimately complement our traditional microprocessors. I will start by showing that spin torque nanodevices, which are multi-functional and tunable nonlinear dynamical nano-components, are capable of emulating both neurons and synapses. Then I will assemble these spin-torque nano-synapses and nano-neurons into modules that implement brain-inspired algorithms in hardware. The brain displays many features typical of non-linear dynamical networks, such as synchronization or chaotic behaviour. These observations have inspired a whole class of models that harness the power of complex non-linear dynamical networks for computing. Following such schemes, I will interconnect the spin torque nanodevices by electrical and magnetic interactions so that they can couple to each other, synchronize and display complex dynamics. Then I will demonstrate that when perturbed by external inputs, these spin torque networks can perform recognition tasks by converging to an attractor state, or use the separation properties at the edge of chaos to classify data. In the process, I will revisit these brain-inspired abstract models to adapt them to the constraints of hardware implementations. Finally I will investigate how the spin torque modules can be efficiently connected together with CMOS buffers to perform higher level computing tasks. The table-top prototypes, hardware-adapted computing models and large-scale simulations developed in bioSPINspired will lay the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The application of advanced technologies to the routing of ships through sea ice' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The overall goal of this research project is to demonstrate the feasibility of an ice routing tool for safer and more efficient ship transport in ice-covered waters. Policy recommendations from the study region (Barents and Kara Seas) can be extrapolated to other EU ice infested waters such as the Greenland or Baltic Seas. Two specific objectives follow which integrate new generic technologies:1. to use artificial intelligence technologies to generate high-resolution, operational-quality ice information for ship routing: the work will combine the emerging technology of operational space radar with innovative computing techniques to derive practical information for ice hazard avoidance.Radarsat, the world's first operational space radar, provides 50m resolution information which is sufficiently detailed for tactical purposes. The techniques to be be employed will include a fuzzy artificial intelligence approach, neural networks to functionally fuse data sources and a novel architecture for integrating the strengths of each component methodology.2. to create computer modelling techniques for optimisation of routes in sea ice: the target is to demonstrate the concept of a decision support system to allow identification and quantitative assessment of routes within areas of sea ice. This will take account of vessel characteristics, the ice environment (derived from the results of objective 1) and weather forecasting. The work will conclude with an assessment of the policy and economic implications of the technical areas for EU transport and business. %Work concentrates on Barents and Kara Seas. There will be no field demonstrations of the achievements in the current phase of the work. % - Norwegian National Sea Ice Centre in Tromsoe and other relevant research applications -
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantitative analysis of variability and robustness in spatial pattern formation', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

During embryonic development a single cell turns into a complex organism. This process is characterized by an antagonism between variation and stability. On the one hand, development is a tightly controlled process; tissues need to be specified at the right time, at the correct spatial position, and with a defined size. On the other hand, regulation should not be too rigid, since embryos need to adjust to environmental perturbations and correct errors caused by noisy gene expression. We will study variation and stability during pattern formation in the zebrafish heart. We seek to understand the origin of embryo-to-embryo variability as well as robustness against perturbation.The zebrafish heart is a powerful model system for studying variability, since heart positioning is inverted along the left/right axis in 5-10% of wildtype embryos. We aim to identify the mechanism underlying variability in heart positioning and understand its function. To this end, we will combine two innovative approaches: Tomo-seq, a novel method for spatially-resolved transcriptomics developed by the applicant; and single-molecule FISH, a technique that allows absolute quantification of gene expression in single cells.To expand our study of embryo-to-embryo variability beyond gene expression analysis, we will optimize a method for massively parallel single-cell lineage tracing based on CRISPR-Cas. This novel approach will allow us to study embryo-to-embryo variability in developmental lineage specification on the single cell level. We will use this strategy to systematically explore the corrective capacity of the zebrafish heart upon perturbation of progenitor cell pools, and to determine which mechanisms for error correction are activated in the embryo.These quantitative experiments will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multiscale modeling and simulation of biological and artificiallocomotion at the micron scale: from metastatic tumor cells and unicellular swimmers to bioinspired microrobots', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The project addresses the mechanical bases of cell motility by swimming and crawling, and the possibility of replicating the principles behind them in artificial systems.The goals are to elucidate some key mechanisms governing bio-locomotion. In particular, actin- based motility of crawling cells and motility by swimming of unicellular organisms will be studied both in general and with reference to concrete model systems.The study of biological examples of swimming and crawling motility will be used to produce a prototype of a micron-scale bio-inspired motile micro-robot exploiting the miniaturization that becomes possible from the extensive use of active materials.This is a multi-disciplinary research project. The themes arise from the Mechanics of Soft and Bio- logical Matter. The methods are those of Computational Engineering, and take advantage of innovative techniques from Applied Mathematics. The planned research activities rest on the development of new tools and methods in mathematical modeling, numerical simulation, data acquisition on biological systems, and on the construction of prototype devices.***
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering the role of immunoglobulin classes in shaping Follicular Lymphoma molecular heterogeneity and evolution' to be submitted under Horizon Europe.

assistant: **Abstract**

Follicular lymphoma (FL) is the second most common B cell neoplasm, characterized by the t(14;18) chromosomal translocation, resulting in deregulated BCL2 oncoprotein (BCL2tx+). In situ follicular neoplasia (ISFN) represents an early precursor lesion, histologically identified as BCL2+/CD10+ Germinal Centers (GC), that might progress into FL. Spatial and temporal genomic analysis in FL revealed that its transformation into aggressive high-grade MYC/BCL2 Double-Hit lymphoma (DHL) arises predominantly from a common precursor that clonally diverges upon the acquisition of genetic hits through iterative GC transitions. Expansion of FL B cells requires the presence of a functional B cell- receptor (BCR), which can be expressed in either unswitched (immunoglobulin M (IgM) or switched (IgG/IgA) isotype. Preliminary data from the hosting laboratory showed an isotype-dependent regulation of Ig levels in FL and MYC/BCL2 DHLs prompting the hypothesis that specific IgH classes may differentially impact pre-tumoral FL lesions, shaping the transforming trajectory of ISFN cells, overt FL cells and finally giving rise to DHL. Using state-of-the-art technologies, including single-cell and spatially-resolved transcriptomics and genetics analyses, I will define IgH-class dependent transcriptional changes in the transition from ISFN to FL and, eventually, DHL and the influence of specific isotype to shape intra and inter tumor heterogeneity and tumor mutational landscape. Finally, I propose to determine whether the immunoregulatory activity of tumor-infiltrating immune/stromal cells is influenced by the expression of defined Ig-isotypes in lymphoma cells. Overall, this action will establish previously uncharacterized roles for distinct IgH classes to determine transforming trajectories pro