RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Isolation of foetal cells from maternal blood: A nanomolecular approach' to be submitted under Sixth Framework.

assistant: **Abstract**

The establishment of non-invasive markers for prenatal diagnosis and is a very important research goal. Current invasive procedures have (1) a significant risk of induced abortion (1-2%) or maternal injury and (2) considerable discomfort and psychological distress. The overall objective of this project is to exploit breakthroughs at the confluences of bio-, micro- and nano- technologies to create a low-cost non-invasive intelligent diagnosis system using a nanotechnology-based device for the isolation, enrichment and detection of foetal cells from maternal blood so as to facilitate non-invasive pre-natal diagnosis. Advances in molecular biology and biosensor technology and the integration of nanostructured functional components in macro and microsystems will facilitate the separation of foetal cells from maternal cells on the basis of cell size, deformability, surface chemistry, novel markers, and charge. Addressing health care requirements of the future of an individualised theranostic approach, the specific application that will be demonstrated will be the isolation of foetal cells with the platform technology being applicable to the isolation of early cancer cells as well as stem cells in peripheral blood. The proposed technology is highly ambitious in nature and meets the ADVENTURE requirements of being a visionary, far-reaching, multidisciplinary project, that contributes substantially to the state-of-the-art with novel technologies of immense impact, with potential applications in non-invasive prenatal diagnostics, cancer diagnostics and theranostics and isolation of stem cells, not to mention the second tier ofsimpler devices exploiting some of the proposed modules for POC diagnostics, environmental and food quality control monitoring. The proposed technology doe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Toward consolidation of germplasm and cell reversible drying through knowledge transfer.' (WhyNotDry), addressing dissemination and exploitation.

assistant: **Impact**

WhyNotDry will deepen our knowledge on reversible drying in cells and germplasm toward the development of a dry biobanking as an alternative to the current freezing in Liquid Nitrogen (LN). LN is expensive, requires dedicated facilities and power supply, and has a high CO2 footprint. WhyNotDry will achieve its aims through a multidisciplinary, intersectoral, international network of scientists that will: i) Develop a drying/rehydration platform using naturally desiccation-tolerant midge (Polypedilum vanderplanki) Pv11 cell lines; ii) Identify the best combination of naturally occurring xeroprotectants (xero=dry) from desiccation-tolerant insect cell line and the best performing water subtraction platform. iii) To use the best xeroprotectants mix and the  drying/rehydration protocol for mammalian cells/germplasm. vi) Develop a prototype for controlled dehydration of microvolumes of cell. The R&I activities leading to these aims will be carried out by knowhow sharing through Staff Exchanges between: 3 EU academies, 2 EU SMEs, 2 international partners (Japan, Thailand). Outcomes of WhyNotDry will be incorporated into a cheap, environmentally friendly, and easy biobanking for biodiversity conservation, assisted reproduction, stem cell/personalized medicine. Successful development of this technology will set the basis for a radically new, ‘green’ biobanking paradigm, simplifying the maintenance and shipping practices in life sciences, with enormous reduction in costs and carbon footprint. Moreover, knowledge generated in WhyNotDry would be applicable to other fields such as agriculture, environmental science, food processing, and the pharmaceutical industry, where elective or enforced (by climate change) drying is dealt with. Finally, WhyNotDry will empower young scientists
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic Electron Imaging with Phase Retrieval' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Quantifying the multiscale functionality of light-triggered hierarchically-structured assemblies represents a challenge in materials science underpinning the design of efficient next-generation optoelectronics, photovoltaics, and energy storage nanodevices. Critical to this challenge is the availability of new metrology and inspection tools which allow to probe the out-of-equilibrium dynamics of these materials, while interacting with light pulses, with quantitative contrast to all its components.DECIPHER proposes to combine phase retrieval image reconstruction methods with the advances in pulsed electron source technology, to build a break-through microscope capable of directly visualizing the nanoscale dynamics of functionalized materials with fs-ps temporal resolution and -nm spatial resolution. The proposal has three main objectives: (i) Construct a next-generation ultrafast electron diffraction imaging system. (ii) Implement cutting-edge phase retrieval methods to enable full-field quantitative imaging across length scales with sensitivity to heavy and light elements. (iii) Leverage these new methods to directly visualize light-activated functioning NP supracrystals, with unique sensitivity to their quantitative chemical/elemental composition and, simultaneously, to their 2D/3D topography. This approach will enable the study of nanoscale dynamical behavior with unprecedented detail and provide vital feedback toward the design of energy-efficient, high-performance devices.


**Keywords:** Ultrafast coherent diffractive imaging, functionalized nanoparticles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovation services for enhancement innovation SMEs capacities in Madrid region in 2020-2021' under Horizon 2020.

assistant: **Concept**

The core objective of the project is to contribute to boost the full innovation potential of SMEs identifying weakness in theirinnovation capacities and in their innovation management capacities; this identification, and the proposed plan, will increasethe efficiency and effectiveness of investments in research, development and innovation; and empower the SME toovercome those weakness.This services will be provide in the framework of the Enterprise Europe Network as support network. The network willprovide the link to the regional innovation ecosystem.To achieve the above-mentioned objectives the proposed project will:a) Identify challenges to the creation of economic impact and innovation needs in SMEs beneficiaries of H2020 fundingschemes SME Instrument (hereinafter referred to as SME-I), Fast Track to Innovation (hereinafter referred to as FTI) andFuture and Emerging Technologies Open (hereinafter referred to as FET-Open).This service is called 'Key account management' (KAM). It is planned about 83 such services during the years 2020-21.b) Increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises (SMEs) withsignificant innovation activities that could potentially become beneficiaries of European funds for research and innovation butwould not have effective access to consulting services for innovation management. This service is called 'Enhancing theinnovation management capacity of SMEs (EIMCS). The aim is to provide about 54 services of this kind.c) Create an active link between the SMEs and the Enterprise Europe Network, offering the beneficiaries of the abovedescribed services SMEs the EEN services.


**Keywords:** innovation, H2020, SME instrument, FET open, FTI, innovation management, COSME
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Using Galaxy Surveys to Understand the Dark Universe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Galaxy Surveys are a key resource for observational cosmology, with the potential to provide the answers to many fundamental questions in modern physics. The Darksurvey project will use the Dark Energy Survey (DES) and extended-Baryon Oscillation Spectroscopic Survey (eBOSS) within which Will Percival has key leadership positions, and future projects including MS-DESI to measure the cosmological expansion rate between redshifts 0.5 and 2, testing Dark Energy. Complimentary structure growth measurements will test Einstein's theory of Gravity on the largest scales possible. The large-scale clustering of galaxies will be used to constrain primordial non-Gaussianity, testing and constraining models of inflation. The scale-dependence of the clustering signal will be used to measure the masses of neutrinos through their early Universe effects, and to set constraints on the evolution of galaxies and structure over cosmological time-scales. Parallel development of innovative tests and measurement methods will be undertaken to enable and enhance these results, while joint analysis with CMB and weak-lensing data will be used to perform additional tests, and to break degeneracies present when cosmological models are tested.This grant will consolidate the world-leading position of the group initiated by Will Percival at the University of Portsmouth, and developed over the last 4 years. Furthermore, it will train and develop a group of scientists within Europe with the key experimental skills required for the ESA Euclid mission.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and commercialisation of a next generation sports head guard, embedded with clinically validated sensors, for the detection of sports induced brain injuries.' (NProSend) targeting Horizon Europe.

assistant: **Abstract**

10% of all contact sport athletes (in rugby/football/baseball/boxing) sustain regular concussions & mild traumatic brain (mTBIs) injuries due to linear & rotational head impacts. Globally >4M/annum mTBI incidents are reported in contact sports. With 20.1 concussions per 1000 player hrs, concussion is the most common reported match injury, occurs in 81% of the matches. Currently concussions/mTBI management/treatment costs EU 17B/annum.No existing headgear is clinically approved to provide protection against linear and rotational impacts hence fail to reduce concussion incidents.Contego Sports are developing worlds first clinically approved headgear for contact sports NProSend which will reduce all linear impacts by 75% & rotational by 55% as compared to existing headgear.  NProSend will also provide early detection of concussion/mTBI by processing cumulative effect of head impact data collected by embedded IoT enabled triaxial sensors and processed by AI algorithms.


**Keywords:** concussion,impact protection,clinical evidence in contact sport,bioinformatics,artificial intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Introduction of broadleaf species for sustainable forest management' (SUSTMAN) targeting Fifth Framework.

assistant: **Abstract**

Spruce plantations outside of their potential natural distribution are often unstable due to pest attacks, wind throw, pollution and drought. Despite of fast growth of spruce timber, harvests are often irregular and economical risk increases. Many regions and forest enterprises want to convert spruce forests into mixed broadleaved forests because of biodiversity, recreation, landscaping, and soil nutrient sustainability and to avoid climatic risks. This project addresses key processes and management implications for clear-cut free conversion of spruce stands through introduction of broadleaf species. The project is organised in four work packages that investigate the ecological constrains to growth of under planted broadleaf trees, assess their quality and transfer the results towards forest management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'PReclinical EVAluation and Investigation of  Laterocidamide - A novel antibiotic from a new drug class to overcome polymyxin resistance.'.

assistant: **Concept**

The emergence of Gram-negative bacterial resistance against antibiotics, especially the last-line-of-defense polymyxins, presents a societal threat with the potential to inflict higher healthcare costs and life-threatening patient risks. For decades, physicians have relied on polymyxins as a last line of defense to treat resistant Gram-negative bacterial infections that do not respond to standard antibiotic therapies. However, in 2016, a new polymyxin resistance mechanism surfaced: mobilized colistin resistance (MCR-1). The global overuse of antibiotics, including polymyxins, and a persistent lack of novel antibiotics have made us vulnerable to increased bacterial resistance, including the MCR-1 strains, seriously threatening our public health.   In Project PREVAIL, our group will validate the effectiveness of a novel drug, Laterocidamide (LATERO), from a new class of antibiotics to deliver an innovative solution that can mitigate the alarming global surge of antibiotic resistance. Our novel synthetic antibiotic, LATERO, has best-in-class potential to address these challenges with (i) minimal antimicrobial resistance, (ii) Gram-negative bacterial efficacy against polymyxin-resistant strains, and (iii) the ability to be produced at low cost. Moreover, our robust synthetic approach will allow us to generate additional analogs in the future. In PREVAIL, we will explore LATERO's technical and commercial potential. Specifically, we will validate LATERO as a novel antibiotic for (multi-drug-resistant) Gram-negative bacterial infections by performing in vitro and in vivo efficacy and preclinical toxicity studies. In parallel, we will: 1. Analyze the IP position and develop an IP rights strategy to protect LATERO and new analogs developed in the project to secure future assets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hybrid Nanowire Devices for Quantum Information Processing' (HYWIRE) under Seventh Framework.

assistant: **Objectives**

Semiconducting nanowires are a promising materials system for quantum information processing applications. Presently, there is much interest in using nanowires to support both spin qubits and, when contacted by a superconductor, Majorana fermions. The overall aim of the proposed research will be to develop the next generation of hybrid superconductor semiconductor nanowire quantum devices using ultra-clean InSb nanowires grown by molecular beam epitaxy. We will develop new device assembly techniques and sensitive charge detection schemes to explore and control single spin quantum coherence. Nanowire devices will be coupled to superconducting microwave resonators in order to demonstrate coherent spin-photon coupling and probe Majorana bound states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systemic Endotoxemia as the driver of chronic inflammation - Biomarkers and novel therapeutic targets for Arthritis' in the context of a Horizon Europe call.

assistant: **Objectives**

Rheumatic diseases (RDs) affect more than 40% of Europe's population and cause significant disability, pain, reduced lifespan and a very high economic burden. In this project, we will explore the role of chronic systemic inflammation caused by intestinal microbiota derived immunologically active compounds, as a driver in the transition from health to disease, with a special focus on three RDs; osteoarthritis (OA), rheumatoid arthritis (RA), and spondylarthritis (SpA). We aim to explore the relationship between gut microbiota, intestinal permeability, and endotoxemia. We aim to understand their role as drivers of disease onset and disease activity in RA, SpA and OA, as well as targets of preventive and therapeutic approaches. We will study the events leading from health to disease onset by i) taking advantage of geographically diverse large cohorts of people with available blood and faeces samples, ii) search for novel risk biomarkers for RA, SpA, and OA by using high-throughput OMICS-based analyses iii) conducting targeted clinical studies, iv) performing in vitro mechanistic studies to explore the gut-joint axis using tissue explant cultures and organ-on-chip models v) conducting interventional proof of concept studies of diet, faecal transplantation and a gut permeability decreasing drug in RA and SpA patients, vi) exploring in vitro new potential drugs or nutraceuticals to cope with endotoxemia effects on target tissues.  By combining all these results, machine learning and AI-informed rheumatic disease prediction tool will be developed for clinicians to help them identify patients with increased risk of developing the target diseases. It will thus assist in the choice of personalized blueprint intervention to reduce the risk of these diseases and disease activity in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable integrated approach to achieve CECs and PTEs removal from contaminated waters. The aquaculture as case study' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Nowadays, the contamination of water resources coupled with the increased food demand is becoming a key issue. Concerning water, monitoring the quality of the water and its toxicological load is mandatory to guarantee the consumption of pure water to citizens; besides, we need to expand access to pure water by planning actions able to treat contaminated water using environmentally sustainable technologies with the final aim to guarantee a low cost and microbiologically safe water. Concerning food demand, aquaculture is the fastest growing food producing industry globally. It accounts for 47% of fishery products, which is estimated to reach 62 % by 2030.The project aims to face both sides of the coin by applying an integrated approach. On one side, we will develop new tools useful for eliminating pollutants. Different strategies will be adopted, all commonly sharing a low environmental impact. Fungi will be used to eliminate contaminant of emerging concern (CECs), with particular focus on antibiotics and some lipophilic compounds responsible of unpleasant taste on fish. On the other hand, potentially toxic elements (PTEs) such as dissolved As, Hg, Pb or Cd species will be captured by exploiting the use of iron, adsorbents derived from biomass and inorganic oxides and photocatalysts jointly linked to strengthen their efficiency.  The highest performing materials will then be supported on membranes or columns and will be tested in water for aquaculture or for reuse. In all sites, we will also assess the quality of water by monitoring CECs and PTEs in influent, effluent and post treated waters and by assessing the ecotoxicity and estrogenicity through the combination of different bioassays. The monitoring process will involve not only toxicological assays and chemical analy