RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Promotion of clean energy technology initiatives in India sub-continent and Asean region'.

assistant: **Innovation**

The objective of the proposal is to host the OPET-Associate for the Indian sub-continent and the ASEAN region (ICAS), to service needs of three clean Energy sector(s) , namely:Energy efficient technologies and innovation in Industrial units (SMEs), Conventional power generation and Renewable Energy TechnologiesThe proposed OPET-ICAS will carry out the following key services, as an associate member- Assessing the real market needs to encourage the utilisation of clean and energy efficient technologies- Result oriented tasks that respond to these needs by using internet/web based networks, assessment and evaluation studies, workshops and conferences -Use of electronic media and internet-based network for information exchange.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Supporting the EU access to Chinese research & innovation programmes' (CHINAACCESS4EU) under Seventh Framework.

assistant: **Objectives**

ChinaAccess4EU aims at increasing the awareness and dissemination in the Member States and Associated Countries of access opportunities for European researchers and research organisations in Chinese national research and/or innovation programmes. The overriding purpose of the proposed project is to help develop the reciprocity aspect of the EU-China Science and Technology agreement by identifying the Chinese programmes open to EU researchers and promote their participation, and to provide outputs useful in the context of the Joint Committee meetings of the EU-China Science and Technology  agreement. To this end, the project will focus on the mapping of the access opportunities in China, dissemination of the results to European research organisations and multipliers, monitoring of the participation of researchers from the EU in Chinese programmes, and provision of feedback and recommendations to the EC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unmasking Non-Genetic Determinants Instructing Tumor Initiation (IGNITE)'.

assistant: **Concept**

The gene-environment interaction paradigm has long provided a framework for understanding the contribution of environmental cues to cancer initiation. However, recent perspectives reveal that even amongst genetically identical cells, responses to environmental variation can be remarkably diverse. When and how pathogenic gene-environment interactions effectively ignite cancer remains ambiguous.IGNITE aims to explain what drives cancer initiation beyond genetics by dissecting (mal)adaptive responses to environmental variation at the cell, tissue, and organismal level, taking inflammation-driven pancreatic cancer as a disease paradigm. I hypothesize that qualitatively distinct forms of local and systemic inflammation, which I refer to as “inflammatory contexts”, direct tumor evolution in ways that are largely predetermined by epigenetic fingerprints integrating cells’ lineage, mutational, and environmental exposure history. Hence, I will (1) identify epigenetic determinants underlying the differential potential of pre-malignant and malignant cell states to sense, communicate and evolve within distinct inflammatory contexts; (2) define tissue-level hallmarks of pathogenic vs homeostatic inflammatory contexts, and develop new approaches to engineer immune cell states distinguishing each; and (3) dissect poorly understood links between pancreatic cancer risk and distal inflammatory disorders to uncover organismal mechanisms. IGNITE’s multi-layered perspective of cancer susceptibility and evolution will integrate methodologies to map and functionally interrogate molecular, cellular, tissue, and systemic traits in human samples and physiological models to establish causal relations.In sum, IGNITE will unmask yet-unknown contextual determinants of cancer beyond genetic susceptib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Accelerating circular bio-based solutions integration in European rural areas' to be submitted under Horizon Europe.

assistant: **Abstract**

The main objective of BioRural is to create a pan-European Rural Bioeconomy Network under which related stakeholders will cooperate to promote the currently available small-scale bio-based solutions in rural areas to increase the share of Bioeconomy, giving increased value in such remote areas. Such framework will contribute in bridging the gap between the available novel high-end bio-based solutions and the everyday European rural life by assessing the existing situation of European rural Bioeconomy, capturing grassroots-level needs and ideas, promoting effective exchange of knowledge and information and investigating the possible opportunities for regional development through the expansion of bio-based solutions integration in rural Europe. This way, BioRural will develop a transition framework towards a sustainable, regenerative, inclusive and just circular Bioeconomy across all Europe at local and regional scale and support innovators to scale-up inclusive and small-scale bio-based solutions in rural areas. To do so, the project will:  (i) Assess and evaluate the current performance of the European rural Bioeconomy in the EU and identify factors affecting innovation adoption and diffusion of bio-based solutions in rural areas; (ii) Create four regional Rural Bioeconomy Platforms (RBPs) that will form a European Rural Bioeconomy Network (ERBN); (iii) Assess and promote success stories of bio-based solutions in rural areas; (iv) Develop and continuously optimise an online open stakeholders’ tool, named BioRural Toolkit; (v) Facilitate knowledge exchange and capacity building for the European rural Bioeconomy through a series of workshops in local, regional and European level; (vi) Create rural development blueprints for regional and business scale-up of resilient and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Strategies and methods for optimisation of internal exposures of workers from industrial natural sources' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Radiation protection of workers requires optimisation to keep radiation exposure as low as reasonably achievable (ALARA). This requirement applies to external and internal radiation exposures. However, relatively few efforts have been directly devoted to implementing the ALARA approach for internal exposures.In many situations in industries involving natural radioactivity, internal contamination by inhalation is potentially the most significant exposure pathway. Exposure situations differ with respect to work place conditions and radionuclides involved. In SMOPIE the characterisation of these situations will be carried out in a number of case studies. They will describe real exposure situations and will be carried out with the full co-operation of industrial partners.The case studies will provide the basis for recommended monitoring strategies and methods for optimising internal exposure in a wide range of exposure situations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PROtective composite Coatings via Electrodeposition and Thermal Spraying' to be submitted under Horizon 2020.

assistant: **Abstract**

Wear and corrosion of materials causes losses of 3-4% of GDP in developed countries and billions of Euros are spent annually on capital replacement and control methods for wear and corrosion infrastructure. As a result many important industries are dependent on surface engineering of protective coatings, making it one of the main critical technologies underpinning the competitiveness of EU industry. There are 2 main techniques that dominate the protective coatings sector: hard chromium (HC) plating and thermal spray (TS). However, HC plating faces a series of issues with most important the extremely negative health and environmental impact leading to the EC restriction of this method for using Cr+6 by the end of 2017. Similarly, recent toxicity studies concerning Co-WC cermet applied by TP have revealed that Co-WC particles are toxic in a dose/time-dependent manner. Consequently, there is the necessity of finding new, less hazardous methods and materials exhibiting the same or better performance compared to existing ones. The PROCETS project will took advantage of the use of nano-particles for production of composite coatings with superior properties compared to those of HC produced by electroplating or to Co-WC produced by TS. These novel nano-particles will be incorporated into existing production lines after appropriate modifications. The new procedures will be easily transferred by minor adaption to the present electroplating and TS facilities, and will combine flexibility and mass customization abilities, restrict environmental and health hazards and finally be available at acceptable cost. Thus, PROCETS main target is to deliver protective coatings covering a wide range of applications such as automotive, aerospace, metal-working, oil and gas and cutting tools ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kid mechanism of action in human cells-links to apoptosis' (1998-2002).

assistant: **Innovation**

Prokaryotic toxin Kid inhibits proliferation of eukaryotic cells and triggers apoptosis in human cells, whilst its natural antidote Kis, protects from these effects. Modulation of the intracellular relative levels of Kid and Kis have been used to selectively regulate cell proliferation (or cell death) in eukaryotic cells. This approach may allow targeted cell ablation of cancer cells or of specific cell lineage during development and has potential in gene therapy strategies and in developmental studies. To achieve these goals it is important to understand Kid s mode of action in eukaryotic cells. Preliminary results show that Kid inhibits eukaryotic DNA replication, arrests yeast cells in G1 phase of the cell cycle and inhibits proliferation of human cells which die by apoptosis. On the basis of these observations, the main purpose of this project is to investigate the precise mechanism of action of Kid in human cells and how it is linked to inhibition of cell proliferation and to the activation of cell death.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Targeting Type 2 Diabetes with Allene-containing Molecules Using a C-N Bond Cleavage Tool'.

assistant: **Innovation**

Type 2 Diabetes is a chronic disease affecting more than 450 million people world-wide and is still an unmet medical need. PPAR´s(Peroxisome Proliferator-Activated Receptors) and G-protein-coupled receptors (GPCR) FFARs (Free Fatty Acid Receptors) are wellclinical validated targets for type-2 diabetes. Although selective GPR40 agonists have reached clinical phase III, the trials wererecently terminated due to signs of liver toxicity in patients. ALLENEDRUG is designed to provide a new chemical series of GPR40ligands aiming to bring a safer type-2 diabetes therapy. To achieve this goal, we will use a synthetic tool developed in our laboratoryto prepare enantiomerically enriched allenes through a selective C-N bond cleavage. This ERC-PoC will allow us to test the newchemical series as potential GPR40 agonists and to get insight into a SAR (Structure Activity Relationship) correlation with liver toxicityin order to compare the new molecules prepared in this proposal with those currently in clinical phase III trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Highly multiplexed, quantitative protein biomarker profiling (hmqPro)' (2021-2027).

assistant: **Concept**

The project will develop a multipurpose, highly multiplexed, quantitative protein profiling (hmqPro) platform that can be adapted to a wide range of applications, particularly biomarker discovery. Biomarkers are a 43 Billion USD market spanning applications in diagnostics, drug discovery & development, personalized medicine, disease risk assessment. The method comprises an antibody-based profiling of a large number of proteins or protein posttranslational modifications against a large number of samples irrespective of source. Unlike competitor methods, hmqPro does not require platform-specific assay or detection equipment. Dual multiplexing implemented in a variant method, hmqPro-2D, will make the platform competitive against existing protein profiling methods in per-assay cost, flexibility and scalability. The hmqPro platform uniquely complements the technology portfolio of Epigenica AB and we will chart out two commercialization routes: first, hmqPro will be integrated into a service laboratory offering high-throughput sample-to-result epigenome and protein profiling services to academia, pharma and biotech industries. Second, we will package the method in a kit format distributed to R&D and clinical end users. In summary, the proposed project will deliver a new quantitative protein profiling platform that will have the capacity to impact the biomarker discovery market by combining unique flexibility with high-throughput.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ecopaint bio-based formulations' (ECOBIOFOR).

assistant: **Innovation**

The EU solvents market totalled 5.0 Million Tons in 2010. The bio-based solvent consumption was only 0.63 Million Tons (12.6%), mainly devoted to cleaning operations, however the consumption of biosolvents is estimated to grow annually 4.8% up to 1.1 million by 2020 (EU Innova-Biochem 2010).The Coatings/Inks/Adhesives Industry represents 58% of the global solvent consumption, since they use solvents as the main constituent in their formulations (50-70wt%), which will be released in fine to the atmosphere.The environmental/economic consequences are clear. EU Directives (IPPC, SE Solvents & Paints Directives) are pushing companies to develop greener solutions but up to now; despite this concern, only the 1.5% of biosolvents is used in paints. So, the Coatings sector emphasizes the need for new & specific biosolvents.ECOBIOFOR project aims to prepare solvents for coatings with 3 characteristics: bio-based (coming from renewable resources), synthesized according to the principles of Green Chemistry and new formulations with lower VOC emissions.Few large companies are devoted to the transformation of biomass into basic chemical products with established industrial uses. But the business model of a great number of chemical & biotechnological SMEs is based on the development of products ready to be used in specific markets.ECOBIOFOR supports this large group of EU SMEs, working in the goal to shift conventional productive processes into new ones based on renewable resources. Moreover, it profits from the impulse of coating SMEs, which are ready to introduce greener products in their own formulations.Succeeding in such a project requires a multidisciplinary & talented consortium. It consists of 11 organizations from 6 EU countries:- 5 SME-AGs 3 biotech & 2 paint associations wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Computational Modelling of Tangible Objects on Multisensory Interfaces' (TANGO).

assistant: **Concept**

Current interactive systems provide realistic audio-visual feedback while haptic feedback is limited even though haptic interactions with devices are essential and touch plays a large role to convey immersive sensations. Thus, usable high-fidelity haptic rendering has the potential to improve interactions with interactive interfaces and future metaverses. Knowledge has started emerging on haptic rendering and multisensory perception of tangible objects. Still, combining multiple techniques to stimulate the full bandwidth of tactile sensitivity remains a hard challenge and little is known about the perceptual integration of tactile cues such as friction, temperature, or vibrations. Thus, there is the intricate twofold challenge of developing new haptic techniques based on models of cognitive multisensory integration whose investigation requires advanced stimulation techniques. Thus, the originality of TANGO is to address the problem of multisensory rendering of tangible objects from a holistic view by considering simultaneously multi-dimensional haptic techniques, tactile acuity across its psychophysical dimensions, and mechanisms of multisensory integration. Specifically, TANGO aims to 1/ characterize typical gestures and contact mechanics during interaction with real objects. 2/ understand how gestures and the dimension of haptic feedback influence perception of simulated tactile objects 3/ create a computational model of multisensory integration that outputs perceived realism during interaction with objects. Studies will also consider two main population factors: age and sensory impairment. Finally, the outcome from 1-3 will serve to design sensorily rich tangible 3D elements on displays, in virtual reality, and on maps for visually impaired. By a strongly interdiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identifying Spillovers in the Labour Market' (SPILL) under Seventh Framework.

assistant: **Objectives**

Why are firms willing to locate in dense areas although production costs are much higher in metropolitan than in rural areas? As first hypothesized by Marshall (1890), this may be explained by cost or productivity advantages enjoyed by firms when they locate near other firms. The goal of this project is to provide novel evidence on the existence and sources of such agglomeration effects.In the first part of the project, I use job creations and job destructions at a large scale (like the opening or closing of a large plant) to identify agglomeration effects in the local labour market. Local governments are often willing to substantially subsidise plants that may locate within their jurisdiction or loss-making plants that are at risk of failing. The main rational behind these incentives is that the opening of a new plant may lead to additional job creations, while the closing of an existing plant may trigger additional job destructions in the area. The questions I address in this project include: May a plant closing trigger a region’s decline? Can the opening of a large plant create regional prosperity?In the second part of the project, I focus on knowledge spillovers in the labour market as one source of agglomeration effects. While most of the existing literature investigates knowledge spillovers at the city or state level, I investigate knowledge spillovers at the level of the firm where, through face-to-face interactions, they are likely to originate. The questions I address include: do workers learn from their co-workers? How do workers learn from their peers? Is it the quality of human capital, the similarity of skills or the skill diversity among peers that matter?My data are uniquely suited to address these questions, and cover the universe of all workers and esta