RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Development of a first-in-class inhibitor of FIH for cancer immunotherapy'.

assistant: **Objectives**

We plan to carry out a valorisation project for a series of novel small molecule inhibitors of Factor Inhibiting HIF (FIH) that we have developed for the treatment of lung cancer, as a next-generation therapeutic approach in the field of immuno-oncology.The valorisation plan will include: clarification of IP rights and strategy, establishing contacts with potential investors and pharma partners, and verification of the potential of start-up creation. Moreover, valorisation activities will include progression of hits against FIH into a lead optimisation campaign with the aim of designating a candidate drug.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Opet Czech Republic'.

assistant: **Innovation**

The establishment of the OPET Czech Republic aims at the dissemination and exploitation of RTD on renewable energy sources and energy efficiency, both on a national and international scale. Through networking with other OPET Members and the EC, it will serve as a basis for objectively targeted information, which will be distributed to market actors, decision-makers and the public.Promotion and dissemination activities will be performed to improve capacity, encourage initiatives and enhance collaboration with market actors, various project consortia and sectoral technical experts within and beyond the country. In cooperation with other OPETs from CEEC and EU Member States, the OPET Czech Republic will function as a multiplier and enhance European cohesion by distributing project results in EU countries, thus contributing to mutual efforts towards sustainable development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Analysis of nod factor-induced signalling pathways in medicago roots', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The Rhizobium-legume symbiosis results in the formation of a new plant organ, the nitrogen-fixing root nodule. Nodule development is triggered by the Rhizobium lipochitooligosaccharide Nod factors. These bacterial signals induce likely more than one signalling pathway in the host plant roots. One of them results in the activation of the chalcone synthase (chs) gene that is at present the earliest gene induced by the Nod factor. The biological significance of chs activation in relation to nodulation is unknown. We will investigate the expression of chs under different conditions (Nod factors, plant hormones, wild type and mutant bacteria) in parallel to that of the early nodulins and cell cycle genes. These studies would clarify the relationship between chs activation and symbiotic signalling. The Nod factor-responsive chs cDNA will be identified and its corresponding genomic clone will be isolated. Promoter analysis described in the project might serve as basis for the identification of upstream elements required for the activation of Nod factor-responsive genes. Training content (objective, benefit and expected impact) During my PhD Thesis I have acquired experience in standard techniques in microbiology and molecular genetics of bacteria. My postdoctoral stay at ISV would be very beneficial for my scientific formation because my training in molecular genetics would be expanded to higher organisms, as the plant partner of the Rhizobium-legume symbiosis. In addition, I would acquire expertise on techniques focused in RNA, promoter analyses and cloning and expression of eucariotic genes. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Java platform for high-performance and real-time large scale data management' (JUNIPER).

assistant: **Innovation**

The efficient and real-time exploitation of large streaming data sources and stored data poses many questions regarding the underlying platform, including:1) Performance - how can the potential performance of the platform be exploited effectively by arbitrary applications;2) Guarantees - how can the platform support guarantees regarding processing streaming data sources and accessing stored data;  and3) Scalability - how can scalable platforms and applications be built.<br/>The fundamental challenge addressed by the project is to enable application development using an industrial strength programming language that enables the necessary performance and performance guarantees required for real-time exploitation of large streaming data sources and stored data.<br/>The project's vision is to create a Java Platform that can support a range of high-performance Intelligent Information Management application domains that seek real-time processing of streaming data, or real-time access to stored data. This will be achieved by developing Java  and UML modelling technologies to provide:1) Architectural Patterns - using predefined libraries and annotation technology to extend Java with new directives for exploiting streaming I/O and parallelism on high performance platforms;2) Virtual Machine Extensions - using class libraries to extend the JVM for scalable platforms;3) Java Acceleration - performance optimisation is achieved using Java JIT to Hardware (FPGA), especially to enable real-time processing of fast streaming data;4) Performance Guarantees - will be provided for common application real-time requirements; and5) Modelling - of persistence and real-time within  UML / MARTE  to enable effective development, code generation and capture of real-time system properties.<br/>The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'G-quadruplex DNA Structures and Genome Stability'.

assistant: **Concept**

Secondary structures such as G-quadruplexes (G4s) can form within DNA or RNA. They pose a dramatic risk for genome stability, because due to their stability they can block DNA replication and this could lead to DNA breaks. In certain cancer cells mutations/deletions are observed at G4s, if a helicase that is important for G4 unwinding is mutated. Nevertheless, G4s are also discussed to be functional elements for cellular processes such as telomere protection, transcription, replication, and meiosis. The aim of this research proposal is to use various biochemical and computational tools to determine which proteins are essential for formation and regulation of G4s. Proposed experiments will gain insights into both “effects” of G4s, the risk for genome stability and its significant function for the cell. In aim 1 we will elucidate and identify novel proteins that bind, regulate, and repair G4s, especially in the absence of helicases, in vitro and in vivo. Our focus is to understand how G4s become mutated in the absence of helicases, which proteins are involved, and how genome stability is preserved. In aim 2, we will use cutting edge techniques to identify regions that form G4s in vivo. Although there is experimental proof for G4s in vivo, this is not commonly accepted, yet. We will provide solid data that will support the existence of G4s in vivo. Furthermore, we will survey genome-wide when and why G4s become a risk for genome stability. Aim 3 will focus on the in silico observation that G4 structures are connected to meiosis. In this aim we will use a combination of techniques to unravel the biological significance of G4s during meiosis in vivo.Due to the connection of G4s and cancer the data obtained from this research proposal will not only be important to understand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovative mucus secretion stimulation for inflammation control in Inflammatory Bowel Disease' to be submitted under Horizon Europe.

assistant: **Abstract**

Inflammatory bowel diseases (IBDs), such as Crohns disease and ulcerative colitis, are chronic, debilitating conditions affecting millions worldwide. There is currently no cure for IBD, only treatments aimed at inducing long lasting remission. These treatment options act mainly by inhibiting the patients immune system, leaving patients immunocompromised, and come with a high annual direct cost. Even with advanced treatment, most IBD patients will require surgery during their lifetimes. Thus, more affordable treatment option which are not focused on immune suppression are needed. While the etiology of IBDs is not clear, it is thought that breakdown of gut barrier function is a major driver of chronic intestinal inflammation. Indeed, penetrance of luminal microbes into the mucus layer which covers the intestinal epithelium is a hallmark of IBDs. This penetrance and contact of microbes with the hosts immune system drives a proinflammatory response and prevents tissue healing. While performing our ERC-funded research project we found a way to induce excess intestinal mucus secretion in mice. We found this excess mucus secretion protected mice from development of colitis in a model of IBD. We also uncovered the mechanism which controls intestinal mucus secretion and discovered a cheap and reproducible way to pharmacologically induce excess mucus secretion using a bile acid.Our goal is to determine whether pharmacologically inducing intestinal mucus production in preclinical mouse models of IBD can induce and sustain remission. The project's methodology encompasses preclinical trials utilizing three distinct mouse models to rigorously test the efficacy and safety of our innovation. A comprehensive market analysis, informed by stakeholders including healthcare professionals an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Early childhood education eLearning framework, leveraging novel technology for a whole new way of learning music.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Scientific research proves that early music education, specifically by children ages 0 to 5, is a powerful tool for attaining children’s full intellectual, social and creative potential. Numerous research studies show indisputable evidence that learning music at an early age speeds the development of speech and reading skills, leading to improved comprehension. Musically trained children develop to their full potential, in contrast to the outdated, normative learning models.The early childhood educational paradigm has not experienced changes in decades. Current model is qualitative, teacher-centred and universal. On top of that, formal early childhood education suffers many challenges, including budget cuts, very low attendance in ECE by children and inadequate music qualifications of early childhood educators. Today, professional early childhood music education is purchased by parents in the form of private music classes, or one-off music performances. The burden is on the parents to take up private tuition, and the high costs of private, stationary lessons is a major barrier.Pomelody is the world’s first and only, eLearning framework for comprehensive music education for infants, toddlers and pre-schoolers, which we describe as analogous to a combination of Netflix and Spotify. Pomelody combines our eLearning web application, with assisted learning software tools to track, analyse and enhance children’s learning processes, increasing learning impact and the final performance. Pomelody is a direct response to the “gap” between research and practice on early childhood music education, and fills a significant market gap within the edTech and eLearning segments. Pomelody partakes in the rise of a next giant market opportunity, where according to forecast the global eLearn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Singularities near a moving contact line: from sliding drops to avalanches'.

assistant: **Objectives**

The goal of this project is to theoretically study the singularities near the moving contact line of a sliding droplet in relation to the problem of avalanche fronts in granular media. A droplet flowing down a window displays fascinating behaviours; involving bifurcations between singular shapes drop emission and coalescence, which have only recently been characterized experimentally. To describe these phenomena theoretically, one has to overcome a fundamental problem:In classical hydrodynamics the flow naiad moving contact line develops infinite stress and energy dissipation.It remains highly disputed how to couple the microscopes near the contact line to the large-scale dynamics of the drop. Though this has remained scarcely noticed up to now, the same singularity occurs at the tip of an avalanche ingrains flowing down an immobile pile. In this context, there have been promising advances to tie the microscopic grain dynamics near the avalanche front to the long-range fields. We will develop a common framework describing moving contact lines for both sliding drops and granular avalanches. We will employ so-called depth-averaged equations that have successfully been applied tcavalanches, and which are very similar to the lubrication theory for thin fluid layers. The latter will be used custody the drop shapes both analytically and numerically. To couple the continuum description to themicroscopies near the contact line we perform molecular dynamics simulations for both systems. In this multidisciplinary project, we benefit from the rapidly evolving fields of wetting, hydrodynamics and granular dynamics. The project provides a unique opportunity to combine these efforts; there will be a close collaboration with the granular lab at the Cole Normal Superior. For the applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nano-Actuators and Nano-Sensors for Medical Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The NANOMA project aims at proposing novel controlled nanorobotic delivery systems which will be designed to improve the administration of drugs in the treatment and diagnosis of breast cancer. Breast cancer is diagnosed in 1.2 million men and women globally every year and kills 500,000. The NANOMA project proposes a magnetic nanocapsule steering approach that relies on improved gradient coils for Magnetic Resonance Imaging (MRI) systems. MRI systems also provide concentration and tracking information, real-time interventional capabilities and are already widespread in hospitals. It is based on fundamental techniques and methods for the propulsion, navigation and effective targeted delivery of coated ferromagnetic capsules in the cardiovascular system through the induction of force from magnetic gradients generated by a clinical MRI. This proposed NANOMA platform will be a valuable tool to help enhance the efficiency of breast cancer treatments while improving patients recovery time.The project rests on the pillar of six work packages (WPs) , which are further divided into subprojects (SPs). Substantial RandD activities are carried out in WP1-WP4 with the goal to design, model and control the microcapsule. In WP5-WP6 new biocarriers and biosensors made of ferromagnetic particles and special functionalized materials reacting to environmental changes in infected cancer cells are being investigated. As proof-of-concept, an in-vivo breast cancer cell detection platform is realized and evaluated in WP7.  WP8 deals with the effective Europe-wide exploitation and dissemination of the project results. Finally, WP9 manages the project.The project consortium gives almost a guarantee for the project's success.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enabling multi-messenger science with black hole binaries' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Combining electromagnetic (EM) and gravitational-wave (GW) observations of the same object opens windows to new science, from astronomy and astrophysics to fundamental physics and cosmology. The era of such multi-messenger astrophysics began with the recent GW+EM discovery of two binary neutron-star mergers. This proposal will enable novel multi-messenger science with black hole binaries (BHBs) across all masses.Supermassive and stellar-mass BHBs in galactic nuclei are both expected to be surrounded by circumbinary gas disks.  The binary's orbit and the hydrodynamics of its disk are coupled and their evolution must be followed jointly. Our goal is to understand this coupled long-term evolution of BHB+disk systems, along with their corresponding EM and GW signatures.This is an exceptionally well-posed physics problem.  We will solve it through hydrodynamical and MHD simulations of unprecedented size, spatial resolution and duration, incorporating radiation transport, realistic thermodynamics, gravitational radiation and disk self-gravity for the first time. We will predict the EM and GW signatures of BHBs with circumbinary disks throughout their evolution, and apply these to observations in three work packages (WPs).WP1 will perform 2D hydro and 3D radiation-MHD simulations to understand the orbital evolution and the EM and GW signatures of BHBs with circumbinary disks.WP2 will apply these results to robustly identify the first SMBH binaries among AGNs in LSST and other time-domain surveys, and to interpret pulsar-timing array observations of the GW background.WP3 will develop the first self-consistent time-dependent models of AGN disks coupled with the embedded populations of stellar-mass objects, and derive the EM and GW signatures of stellar-mass BH mergers in these d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Discrete and Convex Geometry' (DISCCONVGEO).

assistant: **Concept**

The intimately related fields discrete and convex geometry are fundamental areas of pure mathematics, and have very close ties to applications. The main beneficiary is computer science (the theory of algorithms, computer graphics, network designs), but there are important connections with solid-state physics (structure and growth of crystals and quasi-crystals). The Renyi Institute has been a leading centre of discrete and convex geometry for the last two decades, but its members have much to learn in certain areas to keep pace with the fast progress of science. With the help of the Transfer of Knowledge project, the discrete and convex geometry school at the host can strengthen the scientific potential of its own, on one hand, and the whole European Research Area, on the other hand.The discrete and convex geometry group has always been active in doing and organizing science on an international level. The ToK project can also reinforce the close contacts with scientists in Austria, Czech Republic, Poland, Rumania, Ukraine, etc.; therefore the knowledge transferred to the Renyi Institute strengthens the whole region. Since discrete and convex geometry has applications in and interrelations with many other fields in mathematics, by strengthening the group, the ToK project will increase substantially the research potential of the Renyi Institute in many areas of mathematics, and of Hungarian mathematics as a whole. In particular fundamental achievements are expected from collaborations with the traditionally strong Hungarian schools of combinatorics, number theory and statistical physics.