RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of Mineral Replacement Reactions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In this ITN we investigate the mechanism of mineral reequilibration (phase transformation) in the presence of a fluid phase in a wide range of minerals and rocks, under a range of chemical and physical conditions, using both natural and experimental samples. Interface-coupled dissolution-reprecipitation is a recently defined mechanism which applies to a wide range of mineral transformation phenomena. We apply these principles in individual projects to better understand the mechanisms of processes important in earth sciences and in industry, including metasomatic reactions in rocks, chemical weathering, mineral replacement mechanisms in CO2 sequestration, the aqueous durability of nuclear waste materials, remediation of contaminated water by mineral reaction, and the preservation of stone-based cultural heritage. The research methods bring together a range of complementary expertise, from field-related studies to nano-scale investigations of reaction interfaces using state-of-the-art high resolution analytical methods. The application of fundamental principles of mineral reequilibration to a wide range of applications, together with industrial involvement at all levels will ensure that the project provides a strong platform for training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A complete view of the Universe out to high redshifts' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The primary goal of the present project is to understand, out to high red shift, the evolutionary links that must exist between galaxies, their central black holes, their structural morphologies and their environment - with the latter extending from the immediate neighbourhood up to their location within the cosmic web of voids, filaments, groups and clusters. The spectra and red shift in the COSMOS survey will be used to extract the above-cited information and to carry out a specific scientific project also making full use of the multi frequency data collected within the survey.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development, DEployment and Assessment of Infrastructures and Fleets based on Hythane and Hydrogen as Alternative Fuels for Transport'.

assistant: **Innovation**

The EC aims to substitute 5% of transport fuel with hydrogen by 2020. This projects aims to demonstrate routes to the short to medium term commercial uptake of hydrogen as a fuel within the European transport mix. This will be achieved through practical modification of existing technology (internal combustion engine vehicles) to operate on hydrogen and hydrogen/natural gas blends (Hythane). In this way, substantial CO2 reduction and air quality benefits are achieved and infrastructure deployment is facilitated, with vehicles which can be operated at affordable costs. With an overall objective of developing and deploying low-emission transport systems at a fast pace in European cities, the specific objectives of the project Hyt-Hy are: - Use of hydrogen as an alternative transport fuel, produced as primary or waste stream in a chemical plant orthrough small 'on-site' production facilities - Demonstration and evaluation of hydrogen as an alternative fuel via field tests of car fleets with hydrogen Ivehicles) to operate on hydrogen and hydrogen/natural gas blends (Hythane). In this way, substantial CO2 reduction and air quality benefits are achieved and infrastructure deployment is facilitated, with vehicles which can be operated at affordable costs. With an overall objective of developing and deploying low-emission transport systems at a fast pace in European cities, the specific objectives of the project Hyt-Hy are: - Use of hydrogen as an alternative transport fuel, produced as primary or waste stream in a chemical plant orthrough small 'on-site' production facilities. - Demonstration and evaluation of hydrogen as an alternative fuel via field tests of car fleets with hydrogen I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Lower THz rAdio propagation channeL sounding, parameter Estimation and modeliNg Towards 6G and beyond' (TALENT).

assistant: **Innovation**

The new lower THz band from 100 GHz to 1 THz is considered as a candidate for 6G and beyond systems towards 2030 that require even larger system bandwidths. As wireless systems must be designed with constraints set by the radio propagation channels, understanding the lower THz channel characteristics is essential for realistic system design and performance analysis of communication, positioning and sensing operating at this band. However, they are almost remaining unknown with a few works reported, due to challenges in channel sounder development, low-cost high-resolution parameter estimation (HRPE) and establishing comprehensive and realistic 6G-compatible channel models. The applicant will address these challenges with Professor Fredrik Tufvesson, a world-leading researcher in channel measurements and characterization, at the host Lund University. The applicant, collaborating with experts in the host and secondment groups, will introduce basic theory and technology breakthroughs to explore the new lower THz band, which include 1) a novel real-time channel sounder, 2) a generic HRPE algorithm and 3) spatially consistent channel models. The project will result in at least four peer-reviewed journal papers, four conference papers and related presentations, and other broader dissemination, communication and exploitation activities.Undertaking the formal research and training activities, the applicant will achieve an excellent scientific profile in radio propagation, experienced skills in teaching, supervision, fundraising and management, and enhanced research network. This enables him to develop into an independent and leading researcher and realize his career plan within academia. The project also contributes to Europe’s Digital Decade, a vision and avenues presented by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Neutrophil Extracellular Traps Induced Glial Type I Interferon in the Pathogenesis of Tauopathy' in the context of a Horizon Europe call.

assistant: **Objectives**

Tauopathies, including Alzheimer’s Disease (AD), characterized by the brain accumulation of abnormal Tau proteins, represent a significant unmet medical need. Neuroinflammation is a hallmark of these diseases. Although several neuroimmune regulations, notably involving microglia, have been largely studied recently, the role of neutrophils and the release of neutrophil extracellular traps (NETs) has been overlooked. The TNT project will fill the gap as aimed to (1) characterize the temporal dynamics of neutrophil and NETs involvement vs. Tauopathy progression and (2) evaluate the functional impact of NETs and type I interferon (IFN-I) on disease pathogenesis. Using a combination of approaches, including Tauopathy and Tau seeding models together with post-mortem tissue of patients with primary Tauopathy, the TNT project will advance our understanding of the complex interplay between NETs, glial and Tau pathology, potentially leading to novel therapeutic strategies. The project will study the influence of the biological sex on these mechanisms and assess their therapeutic potential.The host institute provides a robust platform for bidirectional knowledge exchange, with expertise in Tau transgenic and seeding models, 3D glial cell reconstitution, and inflammasome-Tau pathology, significantly enhancing our research on glial cell changes. My expertise in neuroimmunology and neutrophil biology, will be instrumental in advancing ongoing projects at the host lab. The planned training will enhance my research skills while fostering independence, mentorship, and communication abilities, preparing me for leadership. Engaging in mentorship activities and workshops will equip me with skills to guide and inspire junior researchers, and enhance my ability to communicate complex concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Priority for vehicles of essential user groups in urban environments' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objective of the PRIVILEGE project is to identify those categries of traffic which may deserve higher priority than others in terms of guaranteed mobility in overcrowded road networks.A strategy is to be devised that could ensure uninhibited and uncongested access for those traffic categories with higher priority while maintaining a general level of accessibility to every destination for all travellers.To achieve these objectives an analysis of exixiting household data relevant to transport will be carried out. Measures to improve the use of the exisiting transport infrastructure will be worked out, including encouraging modal shift from private to public means of transport. %City of Schwerin, Conurbations in Hessen, Lothian Region (Edinburgh) in UK %There are links with the EUROTOLL project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Use of simple embryos to search for unknown genes controlling cell proliferation and death'.

assistant: **Concept**

Tumourigenesis may result from a de-regulation of genes that normally control embryonic development. We propose to use simple ascidians and fish embryos as tools to analyse the genetic diversity underlying cell proliferation and death. These embryos have a simple genome, and genes similar to human ones. We will perform a systematic screen for genes expressed in areas of cell proliferation and death. Putative roles for the new gene families will be inferred from expression pattern studies (acquired in a database), and then tested in embryos and cancer cells. In particular, we plan to use a novel and extremely potent generation of antisepses oligonucleotides, with potential therapeutic outcomes. The major goal of this project is therefore, by taking advantage of the use of simple chordate entrys, to identify new types of regulators of human cell proliferation and death, which are good candidates to design anti-cancer drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Establishment of a European information network for the field of ethics in medicine, in health professions and in health care' under Fourth Framework.

assistant: **Concept**

This project aims at establishing a standardised European information and database network in the fields of medical ethics, ethics in the health professions, and in health care. It will help facilitate:1. a professionally organised exchange of information across the borders of individual European countries;2. the comparison and analysis between European countries of different ethical viewpoints and standards; and3. the realisation of a European consensus (eg Bioethics Convention of the Council of Europe).As a centralised facility the network will provide the information infrastructure for other BIOMED projects and research in these fields, and it may help solve problems which can arise from the lack of uniformity in regulations or administrative arrangements in the member countries of the European Union.Previous studies and surveys have shown that there is a considerable information technology deficit in the field of biomedical ethics in European countries, especially if compared with other scientific fields with available databases. Up until now, the principal online databases have been BIOETHICSLINE, created by the Kennedy Institute of Ethics, Washington D.C., which contains mainly US literature, and ETHMED, created by the Information and Documantation Centre of the Academy for Ethics in Medicine, Göttingen, Germany. The Göttingen database has been made compatible with BIOETHICSLINE.In the European Database Network, each partner institution from the four participating countries (France, Germany, Netherlands, Sweden) will establish or develop its national database. These databases will contain references to national documents such as journal articles, books, 'grey literature' and legal texts of interdisciplinary fields concerned with medical ethics. These national data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cardiogenomics meets  Artificial Intelligence: a step forward in arrhythmogenic cardiomyopathy diagnosis and treatment' (IMPACT), addressing dissemination and exploitation.

assistant: **Impact**

Arrhythmogenic cardiomyopathy (ACM) is a genetic disease characterized by progressive cardiomyocyte loss and fibrofatty replacement, which in turn lead to the occurrence of ventricular arrhythmias and sudden cardiac death (SCD), particularly in the young and athletes. At present, ACM is uncurable; with an incidence of 1:5000, it can be considered a major CVD disease. The subform involving only the right ventricle is the most common; the majority of its causative mutations are identified in just three desmosomal genes: PKP2, DSP, and DSG2. However, many of the identified variants in these disease genes are still of uncertain clinical significance (VUS) and thus of limited clinical utility. The overall aim of the project is to combine large-scale data from genomics, proteomics and instrumental analysis obtained from patients with data from structural and functional analyses of in vitro (3D microtissue) and in vivo (murine) models, to establish the genotype/cardiac phenotype relationship, potentially leading to a better understanding of the role and impact of known genes and epigenetic factors (ie, miRNAs) on susceptibility, clinical progression, and treatment of ACM.The project’s outcomes will pave the way towards novel therapies for ACM.


**Keywords:** characterization of variant of uncertain clinical significance, cardiac microtissues, artificial intelligence-driven analyses of high throughput screening
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'micro-Fabrication of polymeric Lab-on-a-chip by Ultrafast lasers with Integrated optical Detection' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Lab-on-chips (LOCs) are microsystems capable of manipulating small (micro to nanoliters) amounts of fluids in microfluidic channels with dimensions of tens to hundreds of micrometers: they have a huge application potential in many diverse fields, ranging from basic science (genomics and proteomics), to chemical synthesis and drug development, point-of-care medical analysis and environmental monitoring. Polymers are rapidly emerging as the material of choice for LOC production, due to the low substrate cost and ease of processing. Notwithstanding their potential, LOC commercial exploitation has been slow so far. Two breakthroughs that could promote LOC diffusion are: (i) a microfabrication technology with low-cost rapid prototyping capabilities; (ii) an integrated on-chip optical detection system.In this project we propose the use of femtosecond lasers as a novel highly flexible microfabrication platform for polymeric LOCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. Femtosecond laser processing is a direct, maskless fabrication technique enabling spatially selective three-dimensional material modification. It will be employed in different steps of the LOC production cycle: (i)  rapid prototyping of the microfluidic chip using laser ablation or two-photon polymerization; (ii)  direct fabrication of optical waveguides and integrated photonic components on the LOC for in situ optical sensing; (iii) master tool fabrication for mass production by replication techniques.The laser fabrication technology will enable to implement a variety of microfluidic LOCs with integrated photonic functionalities. In this project we concentrate on two prototypical applications in the fields of food quality and environmental s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strategic high-level transport model', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The HIGH-TOOL project aims at developing a free and open high-level strategic transport model to assess economic, social and environmental impacts of transport policy. The HIGH-TOOL model will allow quick scanning of transport policy options by the European Commission (EC). Input and output indicators of the model will be based on policy targets of the White Paper 2011 and the Roadmap for moving to a low-carbon economy in 2050, but may also be relevant to other areas of transport policy. The EC’s Impact Assessment Guidelines will serve as an important reference to define the model’s output variables.The HIGH-TOOL model will be largely based on equations and elasticity developed in previous or ongoing research projects.The model will serve as a pre-selection tool of policy options that will be further evaluated by more detailed models such as TRANSTOOLS and TREMOVE. High attention will be attached to obtain consistency between HIGH-TOOL and the EU 2012 Reference Scenario.The model will be introduced successively during the project in order to facilitate the participation of potential users: The prototype version will be provided at an early stage, and will be largely based on existing and previous meta-models such as EXPEDITE, SUMMA or TRANSVISIONS. This prototype will be extended continuously by substituting and/ or refining the modelling formulation and adding further functionalities. This evolution process will be carried out under involvement of users, and under consideration of results from testing and validation processes. The development of the model will be accompanied by a Scientific Advisory Board, assembling distinguished experts that represent model users and model developers.The HIGH-TOOL model will provide a web interface allowing users to assess policy opt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Collaborative Platform to Unlock the Value of Next Generation Internet Experimentation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main goal of the HU4NGI project is to bootstrap the current Next Generation Internet (NGI) initiative and turn it into a dynamic, collaborative, and participatory innovation ecosystem capable of more effectively supporting and coordinating activities across the whole R&D landscape. The main idea is to build on top of the results and major achievements of ongoing Research and Innovation initiatives and projects, while giving a major impulse to the whole NGI community by providing an interactive framework that will assist the target stakeholders, including new comers and outside players in related domains, via a unique set of tools and mechanisms. The selected coordination and support tools and mechanisms will be at the core of the NGI ecosystem, which will offer and online collaboration environment to facilitate exchange and promotion of know-how, technical activities to be coordinated, strategic liaisons to be established and managed, performance and progress for the overall NGI initiative to be monitored and assessed.


**Keywords:** FIRE+ Coordination and Support Activities, FIRE+ Impact, FIRE+ strategy and vision, FIRE+ Community engagement, Collaborative Platform