RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Recombination in Adaptive Evolution', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Meiotic recombination is a key source of genetic diversity with considerable implications for the genomic landscape and evolutionary process. By shuffling parental alleles to produce novel haplotypes, recombination impacts the strength of selection on nearby polymorphisms, and can increase the rate of adaptation in natural populations. Recombination defects can have serious phenotypic consequences: inviable gametes, miscarriages and developmental abnormalities. Strikingly, recombination rate differs by orders of magnitude across the genome, among individuals, sexes, populations and species. Despite recent progress, we know little about how molecular constraints and evolutionary forces interact to shape recombination in natural populations. We will close this knowledge gap using threespine stickleback fish—an exceptional evolutionary model system that bridges molecular genetic studies and adaptive evolution in the wild. This research program combines next-generation genomics with cutting-edge molecular biology and transgenics. We will 1) create kilobase-scale maps of the recombination landscape in adaptively diverging populations; 2) genetically dissect factors cis- and trans-acting factors that cause recombination variation; 3) characterize molecular mechanisms of recombination modifiers using cutting-edge techniques; and 4) test evolutionary theory that predicts natural selection favours recombination suppression in hybrids. This will significantly improve our understanding of recombination and introduce sophisticated genetic engineering techniques that further cement sticklebacks as an evolutionary model organism. Our ultimate goal is to understand how molecular mechanisms and natural selection shape and constrain recombination during adaptive divergence. This researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Disaster Distortion: Climate Crisis Representation in Contemporary Transpacific Literature'.

assistant: **Innovation**

I explore how the representation of disasters in contemporary fiction warps our understanding of the threat posed by the climate emergency. To do so, I coin the term disaster distortion. Disaster distortion refers to how catastrophes monopolize the imagination when representing the consequences of climate alterations in ways that restrain or omit other forms of violence associated with human involvement and which are systemic, stretch over longer periods of time, and affect the most disenfranchised. I focus on two ways for fictional disasters to produce this distortion: first, disaster dystopias promotes the idea that the climate emergency is a hypothetical concern and not a pressing issue; second, disasters estranges and alienates human agency and responsibility and exclude acts of interpersonal or environmental care.In this project, I propose to study the challenges of climate crisis representation by fashioning an exercise of comparative literature that explores the deployment of the trope of disasters in fiction produced across the Pacific from the second decade of the twenty-first century onward. I choose to focus on three literary hubs distributed across this space: Japan, Australia, and Mexico. I will select a corpus of up to 12 contemporary novels or anthologies of short stories, 4 for each of the literary ecosystems. The texts will be first analyzed using an interdisciplinary methodology that combines close-reading with qualitative data analysis to examine the mechanisms through which we are imagining the climate emergency.My goals are to devise a theoretical framework that can question the usefulness of the trope of disasters, assess to what extent climate dystopias are rising to the challenge of representing the climate crisis effectively, examine whether rep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Graphene Nanogyroids, a new technological platform for CO2 capture and sequestration'.

assistant: **Concept**

Addressing the urgent global challenge of reducing atmospheric CO2 concentrations requires the development of efficient technologies for carbon capture and sequestration (CCS). The GYR4CO2 project addresses the urgent need to reduce atmospheric CO2 levels by developing advanced carbon capture and sequestration (CCS) technologies. A central focus is on enhancing CCS performance through innovative solid sorbents, by creating novel polymer-graphene composites with highly ordered porous structures. The project aims to synthesize these composites using co-assembly techniques involving graphene oxide platelets and block copolymers from aqueous dispersions. The target is to form negatively curved sp²-hybridized carbon structures, known as Schwarzites, which mimic the topologies of triply periodic minimal surfaces, particularly gyroid morphologies.By meticulously designing these multiphase composites, the project anticipates that the unique geometries will foster stronger interactions with polymer chains, leading to the development of hierarchically porous nanostructures. While theoretical models of graphene gyroid structures exist, GYR4CO2 seeks to realize these nanomaterials experimentally for the first time. The project will also involve synthesizing novel thiol-ene block copolymers, which will spontaneously assemble into gyroid morphologies and be integrated with graphene nanomaterials.The efficacy of these gyroid structures— purely polymeric, graphene, or composite—will be assessed for CCS performance in both individual gas models and real mixed gas systems. The goal is to achieve a CO2 capture capacity exceeding 4 mmol/g, along with high selectivity against nitrogen, oxygen, and humidity. Success in these areas will pave the way for innovative CCS technologies.Additionall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Temporal regulation by Sonic Hedgehog of neural progenitor identity during vertebrate neurogenesis.' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The central nervous system (CNS) is the most complex organ in the vertebrate body, and the patterning of the developing CNS is comprised of a large number of regulatory steps. Many extracellular molecules play critical roles in the precise patterning of the CNS during embryonic development. Among them, Sonic Hedgehog (Shh), a soluble factor produced by the floor plate and notochord, is a strong candidate for the determination of the cell fates in the ventral neural tube. Shh has the characteristics of a “morphogen”- it functions at long range in a concentration dependent fashion to induce several different cell types. How Shh is perceived and interpreted by the receiving cells and consequently gives rise to diversity of cell fates has long been a central problem in neural development. In a recent study, the host laboratory have found that transcription factors of the Gli family are the intracellular mediators that transduce the concentration dependent aspect of Shh signaling; the data suggest that the transcriptional activity of Gli proteins are proportional to the concentration of Shh. However, the duration of Shh signaling also appears to contribute to the inducing activity of Shh. However how cells perceive and integrate the duration of Shh signaling as well as the concentration remains to be determined. To address this issue, this project will define the competence period of the neural progenitors for the Shh signaling and analyse how the temporal regulation of Shh signaling in the development of the ventral neural tube influences cell fate. To this end, we will take advantage of a combination of methodologies that use chick electroporation, time-dependent knock-out mice and zebrafish systems. The aim is to understand the mechanisms by which the competence of undiff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Polypharmacy in chronic diseases: Reduction of Inappropriate Medication and Adverse drug events in elderly populations by electronic Decision Support'.

assistant: **Objectives**

Background: Treatment of chronic diseases in the elderly with polypharmacy poses a threat to patient outcome and involves extensive costs. Little evidence exists regarding the benefits of polypharmacy, but rising evidence shows its harmful effects. Several approaches to reduce polypharmacy have been proposed, but none have been evaluated using clinically relevant endpoints.Aims: Based on a systematic review we will gather current best evidence and develop recommendations to optimize treatment of polymorbid elderly with cardiovascular disease, heart failure, hypertension, atrial fibrillation, diabetes mellitus type 2, musculoskeletal disorders, COPD, and mental diseases. We will then design an electronic decision support (eDS) tool incorporating the recommendations to be applied in primary care. The tool will be evaluated in a randomised controlled trial (RCT) to show that reduction of polypharmacy in the treatment of the target-diseases is beneficial and safe. Using the results of the RCT, the eDS-tool will be optimized and then disseminated for general utilization.Workplan: The project is scheduled for 4 years and will contain 12 work packages. WP1 comprises management of the project. The evidence regarding treatment of chronic diseases gathered within WP2 will be used to develop the eDS tool and an electronic case report form (eCRF) in WPs 3-4. After recruitment of surgeries and patients, and implementation of the tool in WP 5, the tool will be evaluated within a cluster-randomized controlled trial (WPs 6-10). The results of the RCT will be used to optimize the eDS tool (WP 11) which will then be disseminated (WP 12).Impact: The project will contribute to the EIP “Active and Healthy Ageing”. It will improve treatments suited to the needs of older people and lower heal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Social Cohesion, Identity and Religion in Europe, 400-1200' (SCIRE), addressing dissemination and exploitation.

assistant: **Impact**

The period between 400 and 1200 AD saw the emergence of new fundamental modes of identification in Europe. Firstly, strong religious identities took shape and became hegemonial over vast regions where Christian communities developed. And secondly, new kingdoms with ethnic denominations were formed, and the Roman empire gave way to a pluralistic political landscape. Most ethnic designations for medieval and modern states in fact go back to that period. Both processes, not least through their interaction, created new forms of social cohesion, but also of conflict, and had a deep impact on European history up to this day that has not been sufficiently understood yet. Universal religion and ethnic/national particularism have always been regarded as opposite principles. But that is only part of the picture, and the proposed project is intended to look systematically at the ways in which religious and ethnic identities interacted, both as forms of discourse and as social practices.In studying the Early Middle Ages, the project addresses a period that has been neglected in debates about ethnicity and the rise of the nation. By choosing a long-term perspective, it attempts to historicize ethnicity and religion. Specifically, the project will concentrate on the ways in which the Bible inspired new discourses of identity and ethnicity, and in which the formation of Christian communities could enhance ethnic and political cohesion. Important political, affective and cognitive resources for the political role of ethnicity in European history were created in Late Antiquity and the Early and High Middle Ages, c. 400–1200 AD. They provided a potential that could be used at different stages in European history, not least, in the development of the modern nation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Gut-liver axis’ protein impact: Influence of dietary protein on gene expression and metabolic phenotype in the gut-liver axis' (GLAPI) under Seventh Framework.

assistant: **Objectives**

The gut and the liver are the key organs in nutrient absorption and metabolism. The gut adapts to the composition of the diet by direct substrate effects in addition to neural and endocrine mechanisms. These adaptations include the intestinal mucosa and the gut microbiota. Depending on the diet, the profile of nutrients, metabolites, gut peptides and other mediators released from the gut can be modified.The liver is the first organ which comes into contact with the molecules arising from gut digestion. Nutrients and metabolites delivered from the intestine are sensed in the liver and trigger an adaptation of liver function to improve their hepatic processing. These processes together with neural and endocrine mechanisms regulate liver function and exert a direct or indirect feedback control of gut function.This project aims to evaluate the consequences of increasing protein in a context of either a high carbohydrate or a high fat diet on the adaptation of the gut-liver axis in rodents. A high carbohydrate diet induces hepatic steatosis through the stimulation of hepatic lipogenesis. In contrast, a high fat diet is believed to induce liver metabolic dysfunction and steatosis through dietary fat accumulation but also by inducing gut bacterial overgrowth and endotoxemia leading to a pro-inflammatory state in the gut-liver axis.In order to evaluate the effect of protein in both situations, animals are adapted for several weeks to 4 diets including a control high carbohydrate diet, a high protein-low fat diet, a high fat diet and a high fat-high protein diet. The analyses include gene expression and metabolic phenotyping in the gut mucosa and liver, characterisation of the microbiota, gut, liver and peripheral inflammatory state, hepatic lipogenesis and steatosis, glucose ho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Insights from mr-monitoring of animal brain function and dysfunction' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

MARIE CURIE HOST DEVELOPMENT FELLOWSHIPS The Leibniz Institute for Neurobiology (IfN) Magdeburg invites applications for three post-doctoral research fellow positions (two years each). The Institute is a center for learning and memory research internationally recognized in the field of human brain mapping using magnetic resonance (MR) technologies. To extend our competence into the domain of animal research we are seeking for applicants with experience in the fields of - physics/radio frequency electronic engineering - circulation physiology - physico-chemistry / MR spectroscopy. A 4.7 T animal scanner will be used to image and identify the course of certain physiological and pathophysiological changes in brain of several animal models and to transfer new findings and methodological approaches to human and especially clinical studies. We are looking for enthusiastic and highly motivated candidates who will collaborate actively in our research team. Beside expertise in one of the above mentioned fields experience with MR technologies would be advantageous. Additional information and applications including CV and addresses of three referees to: Prof. Dr. Henning Scheich, Brenneckestr. 6, 39118 Magdeburg Phone: (49-391)6263329, Fax (49-391)616160, e-mail : scheich@ifn-magdeburg.de Further information: www.ifn-magdeburg.de The IfN is an equal opportunity employer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Moving around without a brain: Evolution of basal cognition in single-celled organisms' under Horizon 2020.

assistant: **Concept**

Even unicellular organisms have a sense of self -- that basal recognition of where their own membranous boundaries end, and where the extracellular environment in which they inhabit begins. Yet unlike the cells in your body, these primitive lifeforms can reproduce, and exist autonomously, most importantly, they can respond to stimuli, and change their behaviour accordingly. Responsive self-movement is a defining characteristic of life, which for simple organisms is essential to enable to them to explore and react to their surroundings, improve their circumstances, and outcompete other cells. In this proposal, I will determine the sensorimotor pathways of unicellular organisms and the physical mechanisms of early movement control, showing that a nervous system is not required for complex behaviour, particularly, 1) motility originating from cell shape changes by cilia and flagella, and 2) the as-yet unexplained surface gliding movement of diatoms which occurs in the complete absence of shape changes. I will develop novel interdisciplinary approaches, merging physiological experiments on diverse unicellular species with unique behavioural features, with theoretical modelling, mathematical/computational analysis of behaviour, as well as robotics-aided hypothesis testing. To highlight the importance of fast, nonequilibrium sensing in unicells and its significance for the evolution of nervous signalling, I will pioneer the integration of high-speed imaging and live-cell perturbations to resolve and understand previously unseen cellular processes and excitable phenomena. These investigations will culminate in novel designs for long-time behavioural assays which will probe the limits of aneural organisms and their capacity to perceive and interact with their surroundings.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'QUANTUM-ENHANCED FREE-ELECTRON SPECTROMICROSCOPY' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Ultrafast electron microscopy relies on the spatial, spectral, and temporal manipulation of free electrons with nm/meV/fs precision to map the structural dynamics as well as the vibrational and electronic ground and excited states of nanomaterials. With QUEFES I will introduce a conceptually disruptive approach to capitalize on the quantum nature of free electrons and their interactions with matter and radiation fields aiming to obtain previously inaccessible information on the atomic-scale dynamics of such materials, to reveal hidden properties of the quantum vacuum, and to control the many-body state of quantum matter.I will address five challenges of major scientific relevance: (i) the spatiotemporal control over the density matrix of free electrons by interaction with suitably designed optical fields to overcome the current limits of space/time/energy resolution in time-resolved electron spectromicroscopy; (ii) a disruptive approach to map the nanoscale quantum fluctuations and the out-of-equilibrium state associated with optical near fields in vacuum and polaritonic excitations in nanomaterials; (iii) a Fourier-transform-inspired method to image the spatiotemporal evolution of atomic structures, charge carriers, and dynamical screening; (iv) the use of free electrons to flexibly read and write the many-body quantum state of trapped Rydberg atoms and quantum gases; and (v) the realization of all-electron pump-probe spectroscopy combined with the formation of dynamically screened multiple free-electron bound states for lossless charge transport in a semiconductor.I will pursue these research frontiers by relying on the strong interdisciplinary theoretical background of my group at the intersection between electron-light-matter interactions and nanophotonics, introduc