RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Heavy metals in deep accreted ice from vostok, antartica: implications for the origin of the subglacial lake' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The main objectives of the proposed research is to determine various heavy metals, their isotopes and speciation in the bottom part of the 3,623m deep ice core which has been drilled at Vostok station in east Antarctica. This basal ice is mainly refrozen water of the large sub glacial lake. Its analysis will then provide a unique insight on this - 1Myr extreme water body which might be an earth-based analogue of the subsurface oceans which are suspected on the Jovian satellite Europa. Heavy metals have been chosen since they are valuable tracers of the different possible geochemical processes, which might influence the composition of the water of the lake. 19 core sections (depths from -3,200m to 3,610m) will be analyzed. Each section will be mechanically decontaminated to remove the contamination brought to the outside during drilling operations. Various heavy metals will then be determined using ultra sensitive analytical techniques such as Inductively Coupled Plasma Sector Field Mass Spectrometry. In addition, Pb and possibly Sr isotopes will also be determined by Thermal Ionization Mass Spectrometry and organometallic compounds will be analyzed. The analyses will be performed inside specially designed clean laboratories. The data will be the first ever obtained for bottom Antarctic ice. It will provide highly interesting information on the origin, the history and the geochemical environment of this large (14,000km²) unique fresh water sub glacial body. At the beginning the applicant will be trained in the use of ultra sensitive analytical techniques necessary for the chemical characterization of very special samples such as those of the accreted ice of lake Vostok. These samples will require a careful decontamination procedure before the chemical analysis in order t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mechanism of Endocytosis of the Ldl-Receptor via the Autosomal Recessive Hypercholesterolemia protein'.

assistant: **Innovation**

Hypercholesterolemia, high levels of plasma LDL-cholesterol, is a major risk factor for atherosclerosis and premature coronary heart disease (CHD), the leading cause of death in developed countries. The clearance of LDL from the circulation occurs via endocytosis with the LDL-receptor (LDLR) mainly by liver cells. This hepatic recruitment of the LDL-LDLR complex to the clathrin-coated pits is dependent on the endocytic adaptor protein, autosomal recessive hypercholesterolemia (ARH). Consequently, naturally occurring mutations in either LDLR or in ARH lead to sever hypercholesterolemia and premature onset of CHD. Therefore, studying the molecular interactions ARH forms at the cell surface is central to our understanding of LDL internalization and cholesterol homeostasis.Despite large body of structural data on the ecto-domain of LDLR, the structures of either ARH or the LDLR tail are unknown. To gain a detailed mechanistic understanding for the unique function of ARH, this proposal will investigate (1) The molecular basis for receptor recognition by solving crystal structures of ARH with receptor tails; (2) The interaction of ARH with phosphoinositides and with cell membrane via tools from cell biology and biochemistry; (3) The interaction of ARH with clathrin and its major endocytic adaptor AP-2 structurally and biochemically.The multidisciplinary approach proposed here will significantly extends the molecular knowledge on sorting of LDLR to clathrin-coated pits which is highly significant for cellular physiology and for catabolism of plasma cholesterol and cardiovascular health.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'innovative High tEmperAture ThErmal stoRage for iNdustrial AppLications' (HEATERNAL) under Horizon Europe.

assistant: **Objectives**

Industrial processes in the EU released 351 Mtons CO2e in 2020, 8% less than in 2019. In many cases, continuous, high-temperature heat is needed for these processes, and no viable decarbonization solution exists today. Viable, short-term thermal energy storage (up-to 48-hours) would enable the replacement of fossil fuels by industrial waste-heat and renewable electricity. HEATERNAL unites 4 public research teams specialized in prototyping and modelling of thermal systems, phase-change materials and 3D-printing; 2 metals manufacturers; 2 ceramic manufacturers; 1 process engineering SME and equipment manufacturer; 1 SME specialized in LCA and technico-economic analysis; and 1 SME experienced in dissemination and communication. They aim to prototype and model a new thermal energy storage concept combining strong scientific and industrial know-how: (i) innovative phase-change materials and unit designs allowing to increase the unit energy density by 350% versus ceramic bricks, and (ii) manufacturing experience ensuring that materials and units can be rapidly implemented in factories by 2030. Thus, the project will yield a 50kWh prototype (TRL5) and models of the upscaled storage system connected to factories. The preliminary technico-economic study predicts a return on investment below 3 years and levelized cost of stored energy below 6€/MWh. This is 60% lower than molten salt storage, which doesn’t work at sufficiently high temperatures for most metals and minerals industries (steel, glass, cement, ceramics, etc.) HEATERNAL’s solution meets industrial needs, including low footprint, lifetime over 10 years and fast return on investment. The exploitation plan aims to implement the solution in the first factory in 2030. Sales projections are estimated to reach 286M€ from sale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart LightwAve Multi-modal Distributed Acoustic Strain and Temperature sensor (SLAM-DAST)' (SLAM-DAST) under Horizon 2020.

assistant: **Objectives**

Distributed Acoustic Sensing (DAS) and Distributed Temperature-Strain Sensing (DTSS) are two ground-breaking Distributed Fibre Optic Sensor (D-FOS) technologies that allow large-scale measuring and mapping of acoustic vibrations, temperature, mechanical deformations, and pressure in a large variety of consumer-based, civil, industrial, and environmental applications, in particular for attaining the widespread technological nerve system in smart city environments, for instance in smart home/household monitoring (heating, survelliance, fire detection, structural heath, and so forth), as well as in product distribution/logistics (traffic, distribution and plant monitoring). DAS and DTSS employ a low-priced optical fibre cable installed along the assets (e.g. homes/households in a neighborhood) to be monitored for up to 100 km through an interrogator equipment that sweeps a “virtual sensor” to measure the physical parameters individually at any cable point.This project main objective is to develop, prototype and demonstrate, both in civil/industrial and especially in household/smart-city case studies, a new, cost-effective, Smart LightwAve Multi-modal Distributed Acoustic Strain and Temperature photonic sensing system (SLAM-DAST), which will integrate:- Distributed Temperature and mechanical deformation (Strain)  Sensing (DTSS) and- Distributed Acoustic vibrations optical Sensing (DAS)SLAM-DAST aims at securing the conditions of a disruptive market exploitation, at an industrial as well as at a large scale consumer-oriented level, of the project’s results by:- supporting the product characterisation-standardisation through open access to performance test benches;- adopting open innovation policies about general system architecture and embedded data pre-processing;- promotin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Concept for Higher Altitude Operations Phase 2: Towards the integration between Air Traffic Management and Higher Altitude Operations' to be submitted under Horizon Europe.

assistant: **Abstract**

The European airspace above FL550 is expected to become an area where operations will significantly expand as a result of increased new entrants presence representing both aviation and space domains, with estimated business values in the order of  billions of euros per year. The European Air Traffic Management (ATM) system, including ATC’s operational procedures and systems, needs  modernization and adaptation to allow seamless integration of Higher Altitude Operations (HAO) because of vastly different characteristics of vehicles and associated operational, safety and performance requirements.ECHO-2 will build on the deliverables of the ECHO (European Concept of Higher airspace Operations) project, starting from the Concept of Operations, to propose validated solutions paving the way towards the operational integration of HAO in ATM, on three directions:- Space Launch Real Time Monitoring Module and associated working station for the European ATM Network Manager for increased situational awareness at Network level, supporting Air Traffic Flow Management as well as crisis and contingency management. - Procedural Package covering specific ground and air-ground operational integration issues (including for communications, navigation and surveillance means) associated with the integration of High-Altitude Platform Systems (HAPS) operations into ATM- Procedural Package covering specific ground and air-ground operational integration issues (including for communications, navigation and surveillance means) associated with the integration of supersonic, hypersonic and suborbital vehicles operations into ATM.These solutions will propose all the elements needed by the European ATM Network operational stakeholders for a rapid, harmonized and cost-effective implementation of a Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Passenger station and terminal design for safety, security and resilience to terrorist attack'.

assistant: **Objectives**

The aim of the SECURESTATION project is to improve passenger station and terminal resilience to terrorist attacks and safety incidents through technologies and methodologies enabling design to reduce the impact of blast, fire and the dispersion of toxic agents on passengers, staff and infrastructure.Objectives:SecureStation will consider threats from terrorist attacks and safety incidents caused by blast, fire and accidental or deliberate particle dispersion. The four project objectives are:1.To increase resilience of passenger stations and terminals through structural design, interior design, and building services design, realising everyday benefits while designing for security.2.To ensure cost-effectiveness of countermeasures through application of risk analysis methodologies to prioritise actions taken in design and operation of passenger stations and terminals3.To deliver a Constructive Design Handbook addressing new build and retro-fit cases to serve as a powerful decision support tool for owners and operators to increase station security and safety from terrorist bomb blast, CBRN attacks involving particle dispersion, and fire events.4.To create harmonization and the standardization of risk assessment methodologies, technologies and design solutions thereby supporting wide application by the numerous EC public transport organisations and associated key stakeholders.Therefore, the main focus of the SecureStation proposal will be to produce the necessary tools to build safer and more secure infrastructure whilst providing maximum operating resilience. The proposal covers the development of Risk Assessment Methodology (including simulation results), specifically focusing on passenger stations/ terminals (a scenario specific methodology) and the development of a Const
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of spinal anti-inflammatory lipid mediators in inflammation and arthritis-induced pain'.

assistant: **Innovation**

More than 100 million Europeans are affected by arthritis and other rheumatic diseases that cause stiffness, inflammation and swelling in the joints. Notably, pain is one of the most bothersome symptoms reported by this group of people. Pain not only impairs the ability to function and reduces the quality of life, but also forms the basis for an increasing economical burden. According to the European Pain Network, chronic and recurrent pain accounts for nearly 500 million lost working days and a €34 billion hole in the economy every year across Europe. Acute local inflammation is self-limiting and resolves through an active termination program. Lipoxins and resolvins represent novel classes of lipid mediators that function as “braking signals” in inflammation. My recent work has shown that while systemic injection of lipoxins reduces both pain and edema, spinal delivery reduces inflammatory hyperalgesia without altering the peripheral inflammatory state. The lipoxin receptor, ALXR, was found expressed on spinal astrocytes, indicating that not only neurons, but also spinal non-neuronal cells participate in the regulation of pain signaling. The aim with the proposed studies is to 1) expand this work to examine if lipoxin A4 has anti-hyperalgesic effect in models of chronic inflammatory pain using experimental models of arthritis, 2) to include a second representative of anti-inflammatory lipid mediators, resolvins E1, and 3) to explore the hypothesis that pain may be sustained due to an impaired generation of counter-regulatory mediators. In addition, possible molecular mechanism by which lipoxins control astrocyte activation will be explored in astrocyte cultures. These studies promise to provide insights into novel mechanisms of regulation of spinal sensitization and in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mathematical Optimization for clinical DEcision Support and Training' (MODEST).

assistant: **Innovation**

Physicians need to make many important decisions per day. One clinical example is the scheduling and dosage of chemotherapy treatments. A second example is the discrimination of atrial fibrillation from atypical atrial flutter, based on ECG data. Such important and complex decisions are usually based on expert knowledge, accumulated throughout the life of a physician and shaped by subjective (and sometimes unconscious) experience. It is not readily transferable and may be unavailable in rural areas. At the same time, the available imaging, laboratory, and basic clinical data is abundant and waits to be used. This data is not yet systematically integrated and often single data-points are used to make therapy decisions. More and more clinical decision making tasks will be modeled in terms of mathematical relations. I propose a systematic approach that supports and trains individual decision making. The developed ideas, mathematical models, and optimization algorithms will be generic and widely applicable in medicine and beyond, but also exploit specific structures, resulting in a patient- and circumstance-specific personalized medicine.This allows, e.g., a physician to first simulate the impact of his decisions on a computer and to consider optimized solutions.In the future, it will be the rare and unwanted exception that an important decision can not be backed up by consultation of a model-driven decision support system or based upon a systematic model-driven training.MODEST has a mathematical core. It builds on a comprehensive, interdisciplinary work program, based on disciplinary expertise in mixed-integer optimal control and existing collaborations with medical and educational experts. It is both timely, given the increasing availability of data and the maturity of ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Highlighting the role of women in research professions in Europe through television media' under Sixth Framework.

assistant: **Concept**

The strategic objectives of HIGHLIGHT are: 1. To contribute to the process of creation of public awareness on research and scientific careers, and the opportunities which might open up for young people in undertaking such careers. 2. To highlight the role of women in research and scientific professions and to highlight their peculiarities in career and life with respect to men. 3. To enhance the presence of European RTD activities and achievements on television media on a pan-European scale. These objectiv es will be achieved by: ? Identifying four female researchers/scientits out of the HRM and the Marie-Curie Activities, whose professional profiles look potentially attractive for broadcast media. ? Creating and Developing five audiovisual productions (one per researcher) focusing on researchers work, carrer, story and private life. ? Distributing the project?s audiovisual productions to European TV media, by using consolidated access gateways, such as the Eurovision: ? Monitoring the progress of the project and assessing its achievements and success, by measuring the quantity and quality of broadcasts of the HIGHLIGHT audiovisual productions. The expected, measurable results of the HIGHLIGHT project (see WP4 for details on methodology) are: ? To have each of its audiovisual productions broadcasted by at least 5 major national TV stations in 5 different EU countries. ? To reach an overall public TV audience of several tens of millions people. ? To exploit the project?s audiovisual productions by having them archived in reference audiovisual databases for broadcasting usage (including TV stations archives) beyond the end of the project. ? To track as many broadcasts as possible and to retrieve, for each broadcast, broadcasters? edit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Development of Literacy in the Caucasian Territories' under Horizon 2020.

assistant: **Concept**

The development of specific alphabetic scripts in the context of Christianisation in the early 5th century CE meant the beginning of literacy and, by consequence, a decisive step towards independent statehood for three distinct ethnic groups in the Caucasus: Armenians, Georgians, and the so-called ""Caucasian Albanians"". While the former two developed their written heritage steadily until today, the literacy of the ""Albanians"" ended with the Arab conquest in about the 8th c., and only a few specimens of their language have survived, mostly in palimpsests detected in St Catherine’s Monastery on Mt Sinai. For Armenian and Georgian, too, only a limited number of original written texts have been preserved from the ""early"" centuries, i.e. the period between the 5th and 10th cc. CE, and most of these, too, are palimpsest materials.Over the last 20 years, considerable progress has been made in the analysis of the oldest written materials of the three languages preserved in palimpsest form, and the results have provided substantial new insights into their historical development. These insights, which have hitherto been confined to the individual languages, are now for the first time ever to be brought into a cross-language synthesis, which will yield a completely new view on the emergence and spread of writing in the region, taking into account the interrelations between the three languages and the Christian cultures represented by them as well as the influence of external religious and linguistic factors.In a novel interdisciplinary approach, the project combines investigations into palaeography, historical linguistics, codicology, and philology, addressing, e.g., the structure of the alphabets, manuscript types and their chronological development, and the emerging litera