RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Palaeoglaciological advances to understand Earth’s ice sheets by landform analysis' (PALGLAC).

assistant: **Innovation**

Ice sheets regulate Earth’s climate by reflecting sunlight away, enabling suitable temperatures for human habitation. Warming is reducing these ice masses and raising sea level.  Glaciologists predict ice loss using computational ice sheet models which interact with climate and oceans, but with caveats that highlight processes are inadequately encapsulated. Weather forecasting made a leap in skill by comparing modelled forecasts with actual outcomes to improve physical realism of their models.  This project sets out an ambitious programme to adopt this data-modelling approach in ice sheet modelling. Given their longer timescales (100-1000s years) we will use geological and geomorphological records of former ice sheets to provide the evidence; the rapidly growing field of palaeoglaciology.Focussing on the most numerous and spatially-extensive records of palaeo ice sheet activity - glacial landforms - the project aims to revolutionise understanding of past, present and future ice sheets. Our mapping campaign (Work-Package 1), including by machine learning techniques (WP2), should vastly increase the evidence-base. Resolution of how subglacial landforms are generated and how hydrological networks develop (WP3) would be major breakthroughs leading to possible inversions to information on ice thickness or velocity, and with key implications for ice flow models and hydrological effects on ice dynamics. By pioneering techniques and coding for combining ice sheet models with landform data (WP4) we will improve knowledge of the role of palaeo-ice sheets in Earth system change. Trialling of numerical models in these data-rich environments will highlight deficiencies in process-formulations, leading to better models. Applying our coding to combine landforms and geochronology  to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A new option approach to risk assessment and capital requirement' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The aim of this project is to advance and analyse a new model of market exposure of both banks and regulatory authorities. The research proposal sets out to apply the most flexible hedging tools, options, to measure market risk and determine capital requirement in the spirit of Merton (1995). Capital requirement can be assessed as the price of an insurance against any loss. All the assets in a portfolio will be assessed jointly in terms of the price of an option that hedge the portfolio's value. The theoretical model is a framework to price this global" option on a generic asset's portfolio. This new approach tries to overcome the severe limitations of the traditional approaches. The applicability of this model will be assessed empirically: - calculating the option value of the risk on actual portfolios. - comparing this approach with the traditional approaches. 1. becoming a high level specialist in regulatory and risk assessment, 2. linking my two fields of expertize: options and asset and liability management, 3. good training on: exotic option pricing, especially options on a book of assets, regulatory capital requirement and risk assessment, Collaboration with the TREND's network bank Relevance for European Banks and regulatory authorities "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Food allergy risk evaluation based on improved diagnosis, allergens and test methods'.

assistant: **Innovation**

Symptoms of food allergy range from mild oral symptoms to life-threatening anaphylactic shocks. Besides treating the symptoms, the only form of treatment is avoidance of contact between the allergens in the offending food and the patient. Others and we have reduced the allergens in foods by physic-chemical methods, but this has only been partly successful. Genetically modified low-allergenic plants may be an alternative, but the risk of exposure to hidden allergens in unsuspected foods remains. To allow for risk assessment at several levels in the community, we aim to quantitatively describe symptom-eliciting allergen dosages, and to develop sensitive assays allowing producers, authorities and finally the individual consumer/patient to measure allergens in foods. Cereals and legumes are selected for the study, comprising clinical studies, characterization of native allergens, production of recombinant allergens and new analyses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'nSafety Certification of Software-Intensive Systems with Reusable Components' (2007-2013).

assistant: **Concept**

European industry has a great potential to achieve a leading position in the growing global market of safety-relevant embedded systems, provided it is able to devise efficient and industrial-strength methods and processes for their development and certification.nSafeCer targets increased efficiency and reduced time-to-market by composable safety certification of safety-relevant embedded systems. A primary objective is to provide support for system safety arguments based on arguments and properties of system components, as well as to provide support for generation of corresponding evidence in a similar compositional way. By efficient reuse during certification and stronger links between certification and development, a higher degree of component reuse is envisioned.Improved quality and reduced risk during verification, qualification and certification, will increase European industry competitiveness and pave the way for a cross-domain market for components qualified for certification.The main industrial domains targeted in nSafeCer are aerospace, automotive, construction equipment and railway. Other domains such as health care and cross-domain aspects will also be considered.nSafeCer builds on the 2 year ARTEMIS pilot project pSafeCer launched in April 2011. Sharing the same overall goals, the concepts developed in pSafeCer are in nSafeCer advanced into tangible industrial implementations of “project-ready”, unified and seamlessly integrated solutions, and demonstrators of the proof of concepts.Certification guidelines and training examples for various other domains will also be developed. In addition to the deepening of the pSafeCer knowledge, nSafeCer adds scientific objectives, including support for product-lines and cross-domain certification and reuse.nSafeCer brings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Repetition, Parallelism and Creativity: An Inquiry into the Construction of Meaning in Ancient Mesopotamian Literature and Erudition' (REPAC) targeting Horizon 2020.

assistant: **Abstract**

REPAC is a contribution to the intellectual history of Ancient Mesopotamia, one of mankind’s earliest civilizations. The project investigates the relationship between textual form and function in Mesopotamian literature and scholarly compositions. It focuses on exact and variant repetition as a text structuring device and demonstrates that the use of repetition is grounded in a fundamental aspect of the worldview of Mesopotamian learned scribes. REPAC studies literary, magical and mantic texts written on clay tablets inscribed in the Cuneiform script in the Akkadian language dating from the first millennium BCE. Parallelism, refrain, ring composition and similar types of regular, part-repetitive patterning occur on all levels of these erudite textual genres. Textual elements which are separate but yoked together through contiguity and similarity were a major vector for poetic creativity, rhetorical effectiveness and inventiveness in argumentation. Repetition in its various forms was used not only as a means of aesthetic ornamentation. In mantic texts, it opened a way to understand the world through analogical reasoning. Literary texts constructed arguments by elucidating different aspects of their theme through sequences of parallel, but slightly divergent, statements. In magical rituals, repetition was used for magical action through the construction of persuasive analogies. The ubiquity of textual repetition was rooted in the scribes’ belief in the meaningful and causally effective interconnection of words, concepts and things sharing an element of similarity. No sustained effort at understanding this worldview and the importance of analogy as a principle of Mesopotamian literary and scholarly method has ever been made. The project fills this major knowledge gap. It w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'China and Europe taking care of healthcare solutions' (CHETCH).

assistant: **Innovation**

The research project intends to contribute actively to the cooperation between Europe and China, investigating opportunities for mutual integration in the healthcare sector. Cooperation and potential synergies will be examined from a comprehensive perspective, including policies at national and local level, the legal environment, medical practices, healthcare industries and related businesses. An interdisciplinary approach is followed.Researchers in the social science and humanities areas will compare the European and Chinese healthcare systems at different levels, including value systems and ethical issues. The economic expert will analyse the integration reached so far, in the healthcare industries (i.e. technologies, pharmaceutical products, etc.) on the basis of foreign direct investments, trade and micro economic data. The typical cost-benefit tools will be used to evaluate the economic impact of integrating Western Medicine (WM) and Traditional Chinese Medicine (TCM) practices, supporting the medical team of experts.The legal instruments will help define obstacles and plausible solutions that can be generated by the regulatory environment, as well as appropriate solutions to enhance collaboration both at institutional, medical practices and business levels. The team of experts in the medical field will investigate best practices of traditional medical systems using a modern science framework. The team will develop a process of recognition and scientific validation of TCM versus Complementary Alternative Medicine, at different levels.CHETCH is based on the idea that a Europe-China partnership could be a win-win strategy. Europe and China have complementarities that could help each other face their specific needs in the long run.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Sequential and selective patterning of enzymes in modular electrochemical based biorreactor for continuos production of pharmaceutical materials'.

assistant: **Objectives**

The pharmaceutical industry is a major industrial sector in the EU (annual sales of €130 billion). In contrast to other manufacturing sectors, the sector faces a significant challenge in its reliance on batch processes, with synthesis of active pharmaceutical ingredients (API) occurring via individual reaction steps. Such an approach is not well suited to modern manufacturing methods, and reflects a gap in the state of the art in the manufacture of APIs, where flexible plug and play modular systems to manufacture the drug product from raw materials when they are needed reactors are required. PATTENZYME will address this gap by using electrochemical approaches for the targeted and selective immobilization of bio/catalysts in modular 3D printed bio/reactors. The project will utilise a multi-disciplinary approach that combine electrode preparation and characterisation, modelling of fluid flow and rates of reaction, enzyme immobilisation and characterisation with the preparation and characterisation of 3D printed flow reactors. Specifically, PATTENZYME will immobilize laccase on high surface area supports in 3D-printed reactors for the production and controlled delivery of H2O2 to spatially patterned bio/catalysts for enantio/regio selective oxidation reactions with the goal of developing a bio/reactor for the enantioselective oxidation of omeprazol sulphide to esomeprazole. The bio/catalysts will be immobilised on nanoporous gold electrodes at specific locations in the channels of the bio/reactor. Detailed modelling and characterisation studies will be performed to ascertain the optimal location of the catalysts, the architecture of the channels and the flow rate. 3D printed prototype reactors will be produced and characterised to prepare the optimal system for the oxidati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Safe food in a world of changing climate: The doctoral training programme to develop novel control, mitigation and risk assessment methods for biotoxins' to be submitted under Horizon Europe.

assistant: **Abstract**

There is a massive and urgent need to ensure security and safety of the food supply of the growing world population. The ongoing war in Ukraine as well as the energy crisis emphasized this even further. However, agriculture and food industries continue to be vulnerable to problems of contamination with biotoxins produced by plants, algae and particularly by fungi. Global warming and extreme weather events make the occurrence of these toxic metabolites even less predictable. Alarmingly, the EU currently faces a lack of food safety specialists, as recognised by the European Commission. These challenges lay the foundation for BIOTOXDoc – Safe food in a world of changing climate: The doctoral training programme to develop novel control, mitigation and risk assessment methods for biotoxins. The objective of BIOTOXDoc is to train doctoral students (PhDs) in a broad range of skills and complementary competencies - necessary to innovate various scientific fields and approaches, so urgently needed to control and mitigate biotoxins - by taking advantage of a multidisciplinary, multi-sectoral team of world-class experts. The training and research will include development of early warning systems and on‑site testing by portable mass spectrometry. PhDs will develop novel detoxification strategies of biotoxins and will assess the combined toxicity of co‑occurring biotoxins. Moreover, PhDs will develop much-needed rapid as well as confirmatory tests for biotoxins and aim to close major gaps in our current knowledge of biotoxins. The major common link between all PhDs, working on a wide range of biotoxins at different points along the food and feed chain, is the influence of climate change on biotoxin occurrence and the resulting demand of revised strategies to mitigate its impact on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Closing in on missing heritability and immune dysregulation in macular degeneration'.

assistant: **Innovation**

Age-related macular degeneration (AMD) is the most common cause of irreversible blindness in the Western world. AMD has a strong genetic component, and it has been estimated that 50% of the heritability of AMD is explained by common variants in the complement system. Currently the first genetic tests based on a small number of common variants are being marketed, and new treatment modalities are being developed targeted to inhibit complement activation in AMD. However, genetic tests are not likely to be reliable since 50% of the heritability is still unexplained. In addition, studies by my group indicate that complement activation does not play a role in all AMD patients, so they will likely not benefit from treatments inhibiting the complement system.The goal of this proposal is to explain the “missing heritability” in AMD, and to better understand the pathogenic mechanisms underlying the disease. So far the role of rare variants in AMD has been neglected. Based on recent results from my group I hypothesize that a large proportion of the “missing heritability” in AMD is explained by rare, highly penetrant variants in genes that have not yet been associated with AMD. The first key objective of this proposal is to define the role of rare, highly penetrant variants in AMD. I also hypothesize that not only the complement system, but instead a generalized dysregulation of the immune system underlies the pathogenesis of AMD in certain subgroups of patients. The second key objective of this proposal is to understand the pathogenic mechanisms of immune system defects in AMD patients.The detection of rare genetic variants in the pathogenesis of AMD will allow a more accurate genetic risk assessment, enabling preventive measures in individuals at high risk. It will also provide m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'On a free open source extreme scale finite element software' (FEXFEM), addressing dissemination and exploitation.

assistant: **Impact**

The ability of scientific computing to efficiently exploit forthcoming extreme scale machines will have a great impact in almost every field of science. The next generation of exascale computers is expected to reach billions of cores. As a result, high performance scientific software able to efficiently exploit these extreme scale super-computers is strategic in this scenario. However, this target is very challenging and requires ground-breaking advances in numerical algorithms. The free open source software paradigm is the best approach for a software project of this complexity, which will require collaborative research between researchers by top-end experts in different fields.  Nowadays, there are some high-quality libraries for the numerical approximation of PDEs using grid-based methods. These libraries provide the discretization/linearization machinery, leaving the numerical linear algebra to external libraries. In the future exascale scenario, this staggered approach does not seem to be the best option.  The objective of this PoC proposal is to develop a Scientific Computing Library for Frontier Simulations at Extreme Scales. Our idea is to provide a high-quality open source software that combines discretization and numerical linear algebra in a strong way. We mention some of the benefits of this innovative approach that we have already identified/exploited.  Extreme scale solvers will require reducing synchronization and inter-processor communications, even at the expense of extra local flops. In order to do this, (1) nonlinear domain decomposition and (2) time-space parallelization will be favoured, since there is much more local work to be done (nonlinear/time loops). . Further, (3) solver-aware discretizations should also be considered, e.g. replacing local k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'AERODESIGN - Preliminary Design Methodologies' (AERODESIGN) under Seventh Framework.

assistant: **Objectives**

To study the future configuration of commercial aircrafts, it is important to have the most efficient method of preliminary design supported by the most complete database with information on existing assets and validated results. Such combination will set CleanSKY GRA with the right starting point for a preliminary design process that will yield a future advanced technology aircraft. The AERODESIGN project will generate a multi-segment and multi-level technical framework, aimed at creating an entire preliminary design methodology solution providing a realistic preliminary aircraft model based in a data base with existing aircraft data. The main objective of the AERODESIGN project is to find an integrated process of optimization for the design. AERODESIGN divides the preliminary design methodology scope into eight different modules: geometrical, aerodynamic, engine data, weight and balance, mission and low speed performance, costs analysis, engine emissions and noise analysis, each of them being integrated by various technologies that are fused together. The integration will include the use several technologies that will result in a cost effective solution.