RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tropical Statistics: New Frontiers in Max-Linear Data Analysis' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Classical statistics assumes data lies in a Euclidean space, but many problems involve non-Euclidean spaces such as manifolds or polyhedral complexes. Tropical linear spaces, which are polyhedral complexes defined by max-linear equations, are a promising but underdeveloped frontier for statistics. Such spaces capture data from a variety of domains, including phylogenetics, extreme-value theory and global economics, where classical methods fail. This proposal develops fundamental statistical measures such as variation, distributions, and models in the tropical setting.The goal of this proposal is to advance our understanding of statistics in the tropical setting through the following four objectives. (O1) concerns the analysis of variation over tropical linear spaces using tropical principal components under the asymmetric tropical distance. Combining two previous approaches, asymmetric tropical PCA has the potential to offer fast, interpretable analysis of variation of max-linear data. (O2) outlines the next steps for fitting Gauss-Laplace distributions over tropical linear spaces, which is an important step in establishing the foundations of tropical statistics. (O3) defines a tropical probabilistic PCA model, which opens new avenues for statistical testing and Bayesian inference for max-linear data. (O4) implements these advancements in a software package in R, in order to facilitate the use of the results in applications.Together, these advances lay the foundations for a rigorous statistical framework for tropical linear spaces. This will provide new insights and practical tools for researchers across phylogenetics, extreme-value theory, and global economics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optimisation of the development of Poverty-Related-Diseases (PRD) vaccines by a transversal approach, addressing common gaps and challenges', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A number of new vaccines are being developed against Poverty-Related infectious diseases of major public health importance at a global level. The development of all those vaccines is facing the same kind of challenges and gaps, which still prevent 1) the establishment of readily accessible formulation and scale-up process development capacity for neglected diseases vaccines. 2) the establishment of a systematic approach for prioritizing formulation of vaccine candidates using accepted pre-clinical criteria. 3) the development of information-sharing tools to strengthen connections between the scientists, the developers and the clinical investigators. To address those challenges, the European vaccine community needs to establish a shared vision and goals and to identify the activities that could address some of the above-mentioned challenges. The cooperation between the different groups of PRD vaccine developers can bring innovative approaches for accelerating the development of effective vaccines. Among those challenges, several can be addressed through coordination across poverty related diseases, such as: 1) difficulties in accessing to some technology platforms, such as synthetic peptides, recombinant proteins, … for GMP development, and therefore in making rationale decisions on the best industrial approach for the pharmaceutical development, 2) difficulties in accessing certain know-how, such as lyophilisation and lack of formulation platform accessible to academic group, 3) difficulties to access to some delivery platforms, such as adjuvants, virus-like particles … for GMP development and/or to assess the quality and regulatory compliance of those platforms, 4) difficulties to harmonise the safety data collection, 5) the insufficient number of trained scientists ab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative Optical/Quasioptical Technologies and Nano Engineering of Anisotropic Materials for Creating Active Cells with Substantially Improved Energy Efficiency' (IMAGE) targeting Horizon 2020.

assistant: **Abstract**

The principal goal of the project is to combine research expertise in optics, crystallography and material science with efforts in material engineering to go beyond state-of-the-art in the development of highly efficient energy saving optical cells based on electro-, acousto- and nonlinear optical effects and designed to operate in optical and quasi-optical (sub-THz) ranges.The idea of the project arises from recent advances in nano engineering combined with our technology for optimization of effects in anisotropic materials. We aim to benefit from enhanced anisotropic features, considering both materials with natural anisotropy and those with created and/or tailored anisotropy. Background will be developed by calculating parametric effects tensors for selected crystalline materials. Then, two routes to create samples characterized by the highest figures of merit will be implemented. 3D anisotropy analysis approach will be used for finding global extremes of effects under study and will provide technical information needed to manufacture novel nanocomposites with tailored anisotropy. Nanoengineering approach will be based on growing of nanocrystallites along preferable directions and incorporating them into porous host medium. It is expected to achieve considerable improvements of the operating energy characteristics for bulk and nanocomposite materials.It is planned to reach the proof of concept stage for the optical cells with improved performance and compare their characteristics to those, available on the market. Measures will be undertaken for developing the concept into innovative products. The research will be linked to the large-scale training program for the Seconded Staff Members with specific individual objectives. Based on synergies between all participating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EUROPEAN - LATIN AMERICAN NETWORK FOR SCIENCE AND TECHNOLOGY' under Sixth Framework.

assistant: **Concept**

The EULANEST project intends to promote and co-ordinate research co-operation among EU Member States (MS) and Latin American countries (LAC), thus contributing to strengthen the impact of their national programmes on international cooperation in science and technology (S&T) with Latin America. EULANEST is intended to network European policy-makers and programme managers involved in promoting research co-operation with Latin America in all fields of science. This ERA-NET will prepare its partners towards the preparation, design, implementation and development of joint transnational research activities. EULANEST will first map and benchmark the cooperation activities in S&T among MS and LAC, identifying best practices and preparing the ground for a Joint Action Programme with the final goal of the launching of a joint call between the partners. Through these activities EULANEST will contribute to the building of the European Research Area (ERA) and, particularly, to strengthening the international dimension of the ERA by co-ordinating bilateral programmes of research co-operation with Latin America, both within and between European countries In addition EULANEST intends to help to develop a more coherent approach of the EU towards scientific cooperation with emerging Latin American countries, like Chile, Argentina, Brasil,.. in the present Framework and INCO programme where no specific treatment adequate to the characteristics of these countries is available.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Three-dimensional multiscale model for material degradation and fracture in polycrystalline materials' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of this proposal is the formulation and implementation of a three-dimensional multiscale model for material degradation and fracture in polycrystalline materials. The initiation and propagation of cracks is an inherently multiscale phenomenon, in which the micro-scale material features have a direct influence on the macro-continuum response and this in turn affects the micro-state evolution. Single scale analyses are not able to address specific crack problems, due to the inability of capturing essential geometric effects related to different grain morphology, size, orientation and mechanical behavior. Multiscale methods appear to be an effective tool on investigation, as they provide and link information at different scales.The proposed model will be based on a new cohesive grain boundary integral formulation. The outcome of the project will be an high-performance computer code for 3D multiscale analysis of material degradation and damage initiation and propagation in polycrystalline materials. This could be commercialized in the future and find application in the Aerospace and Automotive industries, helping EU gain a competitive edge in this field. The stand-alone microstructure model could find application in the design of micro-devices for bioengineering applications.There are several reasons for the timing of the project: multiscale modelling is an area of recognized importance, the present work goes beyond the state of the art and it will help Europe maintain scientific competitiveness. Moreover, the outcome of the project will help EU industries in the future. Several FP7 projects contribute to this theme and the project will complement those works. Finally, the project will noticeably expand the scientific and complementary skills of the fellow, contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ceramics concept 2000' (CERACON).

assistant: **Innovation**

The end result of CERACON will be a set of computer-supported collaborative work (CSCW) tools to support process industry factories in CAD, functional design, PLC development, simulation of the designed system, production planning, optimisation and pollution control and online monitoring. The tools will be integrated by a common design repository, retaining design information in digital form throughout the life cycle. Some of the tools already exist as stand-alone products or prototypes (e.g. the FMOS production planning system and the P&I CAD system) and will be adapted and integrated, superimposing the object-based plant model onto existing structures, others (e.g. the neural network and fuzzy logic optimisation components) will be built from scratch. The end results will be a modular system from which the end-users can select the components they wish to use, and even add third party components using the public interface to the repository.  CERACON will support the process industry and continuous processing applications at two levels. Firstly, it will benefit the plant design and supply industry, reducing engineering costs by an estimated 20%. Secondly, and more importantly, the project will produce savings in the operation of the plants built and operated using the tools developed in the project. CERACON will produce and test tools specific to the ceramics industry, and building on these results produce generic tools suitable for other process industries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Unravelling Signalling Heterogeneity using DEEP Learning and MECHANIstic Modelling' (DeepMechanism), addressing dissemination and exploitation.

assistant: **Impact**

Signalling enables cells to respond to external cues, but the inherent heterogeneity of individual cell responses,essential for multicellular organization, complicates disease treatment. Heterogeneity arises from drivers atsystem and molecular scales, intertwined through feedback loops, making quantitative understanding andprediction challenging. I will address this by pioneering transformative computational methods that predictphospho-signalling responses by integrating deep learning with mechanistic modelling to integratesystems and molecular scales.By using unbiased pattern recognition of deep learning models, I will learn cell states and simplephosphorylation rate laws. These will be combined with mechanistic models, integrating biologicalknowledge, to build simple and interpretable models that predict signalling responses from baseline omicsprofiles across distinct time-resolved and perturbational conditions. I will apply these methods to investigatedrivers of heterogeneity in receptor tyrosine kinase (RTK) and rat sarcoma (RAS) signalling, in response togrowth factors and targeted inhibitors in cancer cell lines. I will validate the approach by reprogrammingpatient-derived organoids using model-proposed inhibitor combinations.The proposed research will advance our fundamental understanding of signalling regulation and co-regulationwith cellular states. Given the vital role of RTK and RAS signalling in human health, it also holds the potentialfor translational impact. More broadly, the proposed computational methods are versatile and could be appliedto a broad range of biological and non-biological systems.


**Keywords:** mechanistic models, ordinary differential equations, cancer, mathematical modeling, signaling, heterogeneity, plasticity, adaptive resistance, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Support to security end users'.

assistant: **Innovation**

Weak participation of end-users & operators (EU&O) in all the stages of security research is jeopardizing the competitiveness of new solutions & services and Europe’s security. The objective of this 3 year ARCHIMEDES project is to increase the R&T uptake. It will: 1) Develop an Innovation Management methodology enabling EU&O to efficiently benefit from R&T results and promote a common innovation culture; 2) Start a sustainable process for the EU&O driven definition of common operational needs & early R&T demands aligning EU research agendas with EU & MS security policies; 3) Enhance EU&O’ participation in all stages of EU research activities: agenda-setting; participation in projects; improvement of the legal and operational environment; definition of testing, validation and certification procedures; implementation; 4) Promote security EU&O’ networking and a permanent public-private dialogue through the creation of a Forum to also reinforce cooperation with the supply side and explore a sustainable end-to-end approach to Research and Innovation.All these aspects of ARCHIMEDES will be pursued, explored, refined and validated by specific EU&O sectors during 10 roundtables held in different EU countries. A specific Security Forum, linking existing networks of EU&O via a specific web site, will ensure a sustained dialogue and exchange of information, as will three conferences and video/web conferences on specific topicsValidated findings will be provided as input to the EC Security Advisory Group for the planning of future security research activities, and possibly to the Security Research Programme Committee and other networks of stakeholders (ENISA, Frontex, Europol etc).ARCHIMEDES’ Partners represent all sectors of security EU&O and suppliers from across Europe. Through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Towards the Understanding a Metal-Tumour-Metabolism'.

assistant: **Objectives**

A tumour cell uses both genetic and protein weapons in its development. Gaining a greater understanding of these lethal mechanisms is a key step towards developing novel and more effective treatments. Because the metal ion metabolism of a tumour cell is not fully understood, we will address the challenge of explaining the mechanisms of how a tumour cell copes both with essential metal ions and platinum based drugs. The metal-based mechanisms help a tumour to grow on one side and to protect itself against commonly used metal-based drugs. On the other side, the exact description of these mechanisms, which are being associated with multi-drug resistance occurrence and failure of a treatment, still remains unclear. We will reveal the mechanism of the as yet not understood biochemical and molecularly-biological relationships and correlations between metal ions and proteins in a tumour development revealing the way how to suppress the growth and development of a tumour and to markedly enhance the effectiveness of a treatment. To achieve this goal, we will focus on metallothionein and its interactions with essential metals and metal-containing anticancer drugs (cisplatin, carboplatin, and oxaliplatin). Their actions will be monitored both in vitro and in vivo. For this purpose, we will optimize electrochemical, mass spectrometric and immune-based methods. Based on processing of data obtained, new carcinogenetic pathways will be sought on cell level and proved by genetic modifications of target genes. The discovered processes and the pathways found will then be tested on two animal experimental models mice bearing breast tumours (MCF-7 and 4T1) and MeLiM minipigs bearing melanomas.The precise description of the tumour related pathways coping with metal ions based on metallothio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Large scale micro-and nanofabrication technologies for bioanalytical devices based on R2R imprinting' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Roll-to-roll (R2R) technologies are mature core processes in manufacturing lines for graphical printing industry. In several other areas (e.g. electronics or optics) R2R techniques are emerging, being expected to notably lower the unit prices of flexible devices. In particular, recently developed roller-based nanoimprinting methods enable unrivalled throughput and productivity for precise fabrication of micro- and nanoscale patterns. Areas that will benefit strongly from adopting such R2R nanoimprinting technologies are microfluidics and lab-on-chip products for diagnostics, drug discovery and food control. Such devices require combined printing of micro- and nanostructures and large quantities at low unit costs. The project R2R Biofluidics aims on the development of a complete process chain for first-time realization of production lines for two selected bioanalytical lab-on-chip devices based on high-throughput R2R nanoimprinting in combination with complementary printing and manufacturing technologies.Two types of demonstrators will be fabricated targeting application areas, which would clearly benefit from technology advancement in high volume manufacturing, show large potential for commercial exploitation and adopt current standard formats (microtiter plate and microscope slides).Demonstrator 1 will represent an in-vitro diagnostic (IVD) chip suitable for point-of-care applications, showing improved sensitivity thanks to imprinted nanoscale optical structures and microfluidic channels. R2R fabrication will further greatly reduce production costs and increase manufacturing capacity with respect to currently used products. Demonstrator 2 will provide a device for improved neuron based high-throughput screening assays in drug development. It will consist of nano– to mi