RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Effects of global change on hydro-geomorphological hazards in Mediterranean rivers' (FLOODHAZARDS).

assistant: **Innovation**

Mediterranean river basins are characterized by high (often extreme) temporal variability in precipitation, and hence discharge. Mediterranean countries are considered sensitive to so-called global change, considered as the combination of climate and land use changes. All panels on climate evolution predict future scenarios of increasing frequency and magnitude of floods and extended droughts in the Mediterranean region; both floods and droughts are likely to lead to huge geomorphic adjustments of river channels so, major metamorphosis of fluvial systems is expected as a result of global change. Water resources in the Mediterranean region is subjected to rising pressures, becoming a key issue for all governments (i.e. clear imbalance between the available water resources and the increasing water demand related to increasing human population). Such pressures are likely to give rise to major ecological and economic changes and challenges that governments need to address as a matter of priority. Changes in river flow regimes associated with global change are therefore ushering in a new era, where there is a critical need to evaluate hydro-geomorphological hazard from headwaters to lowland areas (flooding can be not just a problem related to being under the water). A key question is how our understanding of these hazards associated with global change can be improved; improvement has to come from integrated research which includes all physical conditions that influence the conveyance of water and sediments, and the river’s capacity (i.e. amount of sediment) and competence (i.e. channel deformation) that, in turn, will influence physical conditions of a given point in the river network. This is the framework of the present project; it is directed to develop an integrated appr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimal transport techniques in the geometric analysis of spaces with curvature bounds' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The unifying goal of the CURVATURE project is to develop new strategies and tools in order to attack fundamental questions in the theory of smooth and non-smooth spaces satisfying (mainly Ricci or sectional) curvature restrictions/bounds. The program involves analysis and geometry, with strong connections to probability and mathematical physics. The problems will be attacked by an innovative merging of geometric analysis and optimal transport techniques that already enabled the PI and collaborators to solve important open questions in the field.The project is composed of three inter-connected themes:Theme I investigates the structure of non smooth spaces with Ricci curvature bounded below and their link withAlexandrov geometry. The goal of this theme is two-fold: on the one hand get a refined structural picture ofnon-smooth spaces with Ricci curvature lower bounds, on the other hand apply the new methods to make progress in some long-standing open problems in Alexandrov geometry.Theme II aims to achieve a unified treatment of geometric and functional inequalities for both smooth andnon-smooth, finite and infinite dimensional spaces satisfying Ricci curvature lower bounds. The approachwill be used also to establish new quantitative versions of classical geometric/functional inequalities for smooth Riemannian manifolds and to make progress in long standing open problems for both  Riemannian and sub-Riemannian manifolds.Theme III will investigate optimal transport in a Lorentzian setting, where the Ricci curvature plays a keyrole in Einstein's equations of general relativity. The three themes together will yield a unique unifying insight of smooth and non-smooth structures with curvature bounds.


**Keywords:** Optimal transport, differential geometry, metric geometry, met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the melting dynamics in turbulent flows' (MELTDYN).

assistant: **Concept**

Dissolving, eroding, and melting processes are ubiquitous in everyday life, nature, science, and technology. The challenge is to accurately predict the melting or dissolution rate e.g. of an iceberg or glacier---relevant for climate change---or of solid reactants in chemical reactors, important to accurately control reaction rates and temperatures. Current predictions for the melting of glaciers are often off by a factor of 100, and different melting models show inconsistencies. No general consensus of the cryospheric modeling has been reached yet. The difficulties in describing melting and dissolution stem from the multiscale nature of these processes (micrometers to kilometers) and the interaction between thermal, solutal, and viscous boundary layers and their complex interplay with the continuously reshaping boundary. A common belief is that melting always smooths the shape. However, from examples in nature and from theoretical analysis, it is clear that flows around melting or dissolving objects can create a rough (dimpled) surface, dramatically increasing the difficulty of accurate predictions.  The objective of the project is to solve the gap in understanding and develop a quantitative understanding of the heat and mass transfer and the resulting melting and dissolution dynamics of fixed surfaces and freely-moving objects in turbulent flows from a fundamental fluid dynamics perspective. To do so, we will perform highly controlled lab experiments and numerical simulations, which allow for a combined experimental, numerical, and theoretical approach to reveal the underlying mechanisms of the melting and dissolution dynamics. Unique experimental flow facilities, the latest 3D optical measurements techniques, and advanced high-performance numerical schemes will allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Excitatory and inhibitory cell assembliesin the cerebral cortex' (2007-2013).

assistant: **Innovation**

The neural assembly underlying the formation of functional networks in the cerebral cortex is conceivably the most complex biological system that exists.  Much of this complexity arises during development through the interaction of dozens of different neuronal populations, which belong to two general classes: excitatory glutamatergic pyramidal cells and inhibitory gamma-aminobutyric containing (GABAergic) interneurons.  Perhaps the most fascinating aspect of the assembly of cortical circuits is that pyramidal cells and interneurons are generated in distant germinal zones.  Pyramidal cells are born locally from progenitors located in the cortical anlage, while interneurons derive from progenitors in the embryonic subpallium.  Much progress has been made recently in understanding the molecular mechanisms that regulate the migration of interneurons towards the cortex, but how interneurons find their appropriate partners to build cortical networks with balanced excitation and inhibition remains an enigma.The general goal of this project is to identify the mechanisms controlling the precise allocation of different classes of interneurons into specific layers of the cortex, where they assemble into neural circuits.  We also aim to determine how the allocation of interneurons into specific cortical layers influences their function.  This project is now possible due to the unique combination of our detailed know-how on the early development of cortical interneurons, including a variety of genetically modified mice available to us, and the application of new technologies to specifically target synchronically generated populations of interneurons.  Our multidisciplinary approach, combining mouse genetics, in vivo functional genomics and electrophysiological methodologies represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '4CWhite -The first high-precision Computer-Controlled Collarbone Cutter for Whitefish' under Horizon 2020.

assistant: **Concept**

Fish processing companies are continuously seeking innovation to minimize their waste, while ensuring the sustainability of the industry. The global fish processing equipment market will keep growing at 4.11% CAGR during the period 2018-2022 with estimated revenues of more than USD 908 million by 2022. At CURIO, we compete amongst leaders in the manufacturing of fish processing equipment. 4CWhite is the first computer-controlled machine specialized in collarbone-cutting from headed whitefish. Using 4CWhite, whitefish processors can expect a high-value yield increase of fish meat up to 2% from manual cutting and 8% from adapted heading machines, which can be translated into millions of euros in value. Taking into account raw material and labour savings, a typical 4CWhite customer will regain their investment in 1-2 years.We have planned several activities to ensure a successful commercialization by 2020. Technical objectives include the optimization and development of the '0’ machines, the optimization of the assembly process and the development of pilots in 4 operational environments with fish processing companies to achieve TRL9. Commercial objectives involve CE marking, commercialization agreements and distribution and service agreements. Communication objectives focus on the development of commercial materials, website and newsletters, advertising in publications and presence in trade fairs.By 2023, our SOM will be of EUR 30 million and we will reach 4% in the global market share in the fish processing equipment. 4CWhite will represent 25% of our global revenues, with 4CWhite revenues reaching EUR 10 million. 4CWhite will impact the profitability of the fish processing industry, increasing yield +2% and reducing wastage by 1.5 points compared to manual cutting. Addit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biophysical characterisation of a protein-activating protein-protein interaction' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Protein post-translational modification is an essential feature of living systems; one of the most common post-translational modifications is phosphorylation. Phosphorylation of proteins is central both to direct regulation of activity and to protein-protein interactions. Within this project we will use the study of a model regulatory protein-protein interaction, dependent upon phosphorylation to provide a training platform in biophysical and structural approaches to protein-protein interactions. The particular protein-protein interaction is the phosphohistidine/phosphothreonine-dependent interaction of the plant and bacterial enzyme, PPDK, with its regulatory protein PDRP.  This regulatory protein appears to be central to the efficiency of photosynthesis in those plants using the C4 pathway of CO2 fixation as well as to the regulation of bacterial growth yet little is known about the molecular details of its action. Protein-protein interactions such as the PPDK-PDRP are ubiquitous in biological systems, it is the combination of thousands of such pair-wise interactions that lead to the collective properties of all cells. The ability to characterise each individual interaction thoroughly in vitro is essential for the continued development of both our understanding of the cell and how to manipulate this behaviour in therapeutics. Through this fellowship, the experienced researcher, Dr Witkowska, will gain essential hands-on experience with the application of the full range of contemporary approaches to such interactions which will enable her to establish herself as an independent researcher in the area upon her return to her home country while maintaining research links with the host laboratory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Next Generation Lab-On-a-Chip For Advanced Diagnostics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Microfluidics technology has revolutionised key applications like drug development, stem cell research, microbiological analysis, medical diagnosis, personalised medicine and chemical biology, just to name but a few. The progress of microfluidics technology has opened a completely new market for Lab-On-Chip systems (LOC), which are miniaturised devices intended to replicate what happens in a real lab, drastically improving cost efficiency, parallelization, ergonomics, diagnostic speed and sensitivity. Considering that the largest majority of microfluidic chips is made of glass or silicon due to the mature manufacturing process and excellent optical properties, surface stability, solvent compatibility, one question is puzzling the LOC industry: how to deal with the increased complexity of systems required by the biotech industry? At Piemacs, a high tech startup company stemming from the pioneering research activities carried out at the EPFL’s Muralt’s lab, we propose a novel technology for the seamless integration of valves, pumps, injectors made with piezoelectric thin films onto polymer microfluidic chips, thus leading to the next generation low-cost and high performance LOC. This will allow monolithic fabrication of LOC using MEMS technology, benefiting from the advancements in MEMS manufacturing. This project will allow us to validate that the technological and business conditions exist to integrate piezoelectric thin films in polymers instead of glass, paving the way to a completely new and revolutionary application, which can potentially reduce the manufacturing cost of advanced microfluidic chips by two orders of magnitude, moving from hundreds of €/chip of most advanced Si-glass chips to few € of fully integrated polymer chips. This would further boost the adopti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Physical Activity as a Crucial Patient Reported Outcome in COPD'.

assistant: **Concept**

Physical activity (PA) is essential in maintaining optimal health in chronic diseases, including COPD.More physically active patients have less hospital admissions and better survival. Validated physicalactivity monitors have become available in recent years, and together with patient report of symptomsand distress of physical (in)activity, this may form a potent new Patient Reported Outcome (PRO) in COPD.In response to the IMI-call this consortium will develop and validate two PRO’s. In phase 1, items forthe PRO will be generated based on input from an updated literature survey, expert opinion and patients. One PRO investigates PA on a daily basis, using a user friendly interface. This allows investigating the impact of exacerbations and the dynamics of improvement after initiating treatment. A second PRO is used during clinical trial visits. A unique feature of the PRO’s is that they will include unobtrusive physical activity monitoring. Validity, reproducibility, responsiveness and minimallyclinically meaningful difference of the PRO’s will be investigated. The new PRO’s will be put in thecontext of other, more conventional outcomes. using path-analysis and structural equational modeling.Development will be in compliance to the guidelines of the FDA and in collaboration with EMEA.Iii phase 2 the PRO’s will be used in 3 large multi-center clinical trials. These trials will contribute tothe validity and health economic value of the PRO’s. They tackle contemporary questions in COPDcare, including pharmacotherapy, PA counseling and pulmonary rehabilitation.The consortium is well equipped to develop PRO’s. It includes academic centers with a solid reputationin COPD research, centers with expertise in epidemiology, experts in conducting systematic reviews,PRO-methodology a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidation of the biosynthesis pathway of the glaucoma drug pilocarpine in Pilocarpus plants' (PiloSyn) under Horizon Europe.

assistant: **Objectives**

Pilocarpine is a plant-derived alkaloid used to treat primary angle closure glaucoma and dry mouth. To meet the commercial demand for pilocarpine, the alkaloid is extracted from wild Pilocarpus plants in the Amazon rainforest. Excessive harvesting of wild populations has led to the official listing of several Pilocarpus species as threatened. Synthetic biology offers a sustainable approach for pilocarpine production. However, to produce the compound in heterologous hosts such as yeast, the biosynthesis pathway of pilocarpine needs to be elucidated first. In PiloSyn, I aim to unravel the natural biosynthesis pathway of pilocarpine, which is currently completely unknown. My host group recently obtained transcriptomics and metabolomics data sets of two Pilocarpus species, and these will serve as the basis of the project. As several pathway options are conceivable for pilocarpine biosynthesis, I will first reduce the number of options by identifying the metabolic precursors of the pathway and by obtaining structural and spatial information about possible pathway intermediates. Then, using the transcriptomics data sets, I will identify the enzymes that catalyze each of the pathway reactions. For this, I will use a learning-by-constructing approach in transiently transformed leaves of Nicotiana benthamiana. The results of PiloSyn can be used to establish a cheap and sustainable pilocarpine source in a heterologous host. This will eliminate the need to harvest wild Pilocarpus plants, thus is preventing their extinction and protecting the fragile ecosystem of the Amazon rainforest. Through PiloSyn, I will expand my knowledge on enzyme discovery and pathway elucidation and receive valuable training to become an independent and mature researcher in plant metabolism.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hyper Performance Motor, Air-Cooled' (HYPERMAC).

assistant: **Innovation**

The development of a more electrical aircraft is a technological transition applied or envisioned for almost all the systems in the aircrafts and helicopters. Together with the electrification of aircraft actuation systems, also the implementation of an electric propulsion can lead to many advantages in terms of reduced specific consumption, noise reduction, weight and volume saving. Anyway this transition is mainly limited by the reliability, lifespan and some safety aspects of electric system.In this context, the objective of this CfP is the design of a motor-drive for aircraft electric propulsion mainly characterized by high reliability, safety and high power-to-weight/power-to-volume ratio.To fulfill this objective, a high performance multi-phase permanent magnet motor drive with modular integrated architecture and fault tolerant capabilities is proposed. Such a system will integrate the electromechanical design with the power and control electronics by mean of a compact double stacks stator architecture. The basic objective is to provide integrated and optimized redundancies in order to fulfill the high power-to-volume/power-to-weight ratio requirements.The integrated system will also benefits from the features of Silicon Carbon (SiC) devices to achieve high performance and reliable power electronics stage since they offer faster switching speeds (up to 100kHz), low losses, the ability to function at high operating temperatures (250°), and therefore the flexibility to further improve the converter system design over a very wide frequency range.