RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Automatic inspection of lyophilized preparations through innovative ICT control system' (LYO-CHECK).

assistant: **Innovation**

The aim of LYO-CHECK project is to create two machines, one pilot machine and one fully automatic industrial machine, for the inspection of lyophilized pharmaceutical preparations intended for injection, based on the two elements of:a)an innovative vision architecture (dedicated software and optical layout);b)an ancillary technology (head space gas analysis) for testing the sterility of the product via container integrity inspection.Pharmaceutical products intended for injection, also called PARENTERALIA, are becoming more and more commonly found in lyophilized form and this trend appears to grow steadily, especially for anti-infectives, biotechnology derived products, and in-vitro diagnostics. In fact, the lyophilized product shows the following characteristics:- Long term storage (more than two years), even at room temperature if stored properly;- Protection from pollution due to microorganisms activity ;- Ease of transport and storage;- Rapid reconstitution of the product in contact with the appropriate solvent;- preservation of the original product features.Nevertheless, the quality-control inspection of products in lyophilized form pose peculiar challenges, needing a dedicated system which is totally different from the one so far applied to inspect parenteral products in liquid form.During the LYO-CHECK project, the pilot and industrial machines will be used for demonstration in operational environment with trials on potential customer’s products. LYO-CHECK project is based on a sound technical and economical/financial feasibility study, and will allow Antares Vision to increase market share in Europe and worldwide with this breakthrough innovation, with a high impact in terms of increased turnover and employment rate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Modulation of foldases for oversproduction of heterologous proteins in streptomycess' (1998-2002).

assistant: **Concept**

Improving the yield of correctly folded heterologous proteins which contain disulfide bonds by stroptomyces lividans may require the assistance of thioldisulfide oxyreductases. As a model the role of various protein disulfide isomerases in the expression and secretion of the h. Medicinalis thrombin inhibitor hirudin will be studied.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SENSors and Intelligence in BuLt Environment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The goal of this project is to develop novel information sensing research and innovation approaches for acquiring, communicating and processing a large volume of heterogeneous datasets in the context of smart buildings, by building an international, inter-disciplinary and inter-sectoral collaboration network through research and innovation staff exchanges and seamless exchange of ideas, expertise, data, testbeds, and know-how. The need to sense and process ever increasing amount of data requires novel engineering that goes far beyond conventional centralised methods, where signal acquisition, communications and data processing are performed centrally and independently. Building on integrating signal acquisition, communications and information extraction into an overarching smart sensing approach, the project will provide a holistic decision support framework for non-residential buildings of the future. The key challenges of providing intelligence to the building lie in ubiquitous sensing, inside and outside the building, and connecting the sensing technology to people and outside world via meaningful decision support. Though significant research has been dedicated to developing novel sensing and instrumentation technologies, further research and innovation advances are needed to integrate physical sensing to data processing via distributed estimation and fusion approaches, giving actionable meaning to the suite of collected data. In that context, it is necessary not only to continuously monitor the environment, equipment, systems and processes, but also to sense occupants’ behaviour inside and outside the building and provide timely response and feedback.The proposal will tackle the above challenges through several routes: (1) new information-driven sensor designs that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'TOXicity assessment on neurons and cardiomyocytes by means of FluoRescence Emitting Electrodes'.

assistant: **Objectives**

Pre- and post-marketing data on drug side effects show that neurotoxicity and cardiotoxicity are frequently missed or underestimated during pre-clinical testing. Neuro- and cardiotoxicity caused by pollutants including pesticides and industrial chemicals are equally difficult to assess. This results in suffering of individuals and in a considerable burden to society. One of the main reasons is that currently available testing approaches have several shortcomings, including sensitivity, human-relevance and suitability for non-invasive long-term recording.This project will develop a revolutionary and fully non-invasive technology to record in-vitro electrical signals from human neuronal and cardiac cells. High spatial resolution, combined with parallel recording of electrical signal coordination and propagation among thousands of neurons or cardiomyocytes, will allow the assessment and quantification of subtle disturbances by toxicants from the drug, pesticides and industrial chemicals sectors. The full non-invasiveness will enable, for the first time, the long-term functional in-vitro monitoring of biologically relevant cellular models, paving the way toward the reliable assessment of chronic toxicities.The novel biosensing technique (VICE) will emerge from the efforts of nanotechnology developers in close collaboration with toxicologists and specialists in surface functionalization and electrophysiological data acquisition. With its joint expertise, the consortium will continuously refine the VICE biosensor with innovative functionalities while thoroughly testing it in toxicology and pharmacologicy experiments. This will not only lead to a revolutionary approach to monitor functions of heart and brain cells, but also ensure the direct applicability to relevant questions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A life-event oriented framework and platform for one-stop government' in the context of a Sixth Framework call.

assistant: **Objectives**

Online one-stop government enables 24 hour, single point access to public services that are integrated around citizens needs (usually life-events). Currently however, online one-stop government projects do not care about citizens needs and do not provide integrated services from different back-offices. The OneStopGov project aims to specify, develop and evaluate a life-event oriented, integrated, interoperable platform for online one-stop government. This platform will be accompanied by a coherent framework for realising and exploiting online one-stop government at all levels. The guiding vision, challenge, innovation and unique selling proposition for the OneStopGov platform involve: the inherent support of life-events; the active, citizen-centric approach; and the definition and use of generic models (e.g. generic workflows, generic reference models).The OneStopGov platform will be based on a number of scientific and technological innovations. First, the life-event ontology will be specified to enable proper representation of the life-event concept. Second, the active life-event portal will be implemented to care for citizens' needs and circumstances. Third, a complete set of life-event reference models will be specified to allow implementing virtually any life-event. Four, these reference models will be implemented using generic workflow Web technologies. The OneStopGov platform and framework will be deployed in three new Member States (Slovenia, Hungary and Poland) and one Accession country (Romania). The platform will be used for modelling, implementing and deploying 16 life-events. The consortium includes two organisations responsible for eGovernment at national level (Slovenian ministry of Public Administration and the company owned by the Hungarian Prime Ministe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deconstructing the Translational Control of Myelination by Specialized Ribosomes' (MyeRIBO), addressing dissemination and exploitation.

assistant: **Impact**

The myelin sheath is essential for neuronal function and health: myelinating glial cells speed up propagation of axonal potentials, fuel the energetic demands and regulate the ionic environment of neurons. Lesions to the myelin sheath thus result in devastating neurological disorders that include multiple sclerosis, diabetic neuropathy and Charcot-Marie-Tooth disease. Myelination involves a striking expansion of the glial cell membrane that relies on an exceptional increase in protein and lipid synthesis rates.  Decades of dedicated research has uncovered a complex transcriptional program that drives this process, whereas translational control mechanisms, on the other hand, have received little attention. There is emerging evidence, enabled by modern techniques, that ribosomes, typically viewed as invariant, passive molecular machines, may instead be heterogeneous in composition, with particular ribosomal components having a specialized regulatory capacity for preferential translation of specific mRNAs. In MyeRIBO, I propose that translation control by specialized ribosomes is a novel layer of regulation that shapes the proteome of the myelinating glial cell. I will exploit advances in cryo-EM and quantitative proteomics analyses to discover the nature and diversity of ribosomes in myelinating cells, employ genome-wide ribosome profiling to obtain mechanistic insights into selective mRNA translation by heterogeneous ribosomes, and generate genetic mouse models to determine the functional consequences of this specialization for myelination in vivo. Notably, I will study the implication of this mechanism in pathogenesis of injury-induced demyelination and diabetic neuropathy, and evaluate the targeting of specialized ribosomal components as a preclinical strategy. MyeRIBO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identifying best practices for successful facilitation of science learning through general interest television programming' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Science communication is an almost non-existing field in the Israeli Academia and I see as my professional goal to spearhead its development. Therefore, the research proposed is aimed at identifying best practices for successful facilitation of science learning through general interest television programming, in order to increase the general publics' science literacy. This research proposal has a strong interdisciplinary aspect: it is situated at the crossroad of science education (specifically in free choice settings) and science communication (specifically science journalism). It is planned to enable me to take advantage of my existing skills, and at the same time gain knowledge of new research methodologies. So far, my research and training has been in the field of Science Education. This discipline does share similarities with the field of science communication, such as theoretical background and research methodologies in the area of informal science education. However, notwithstanding those similarities and my personal background as a science communicator (reporter, editor and TV presenter) it is clear to me that to meet my professional goals I need the superb formal science communication training that is available in Cornell under the guidance Prof. Lewenstein. As a junior faculty member it is important for me to develop my own niche in the academic environment and in order to further my academic position I am required by my University to complete a Post Doc in another country.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthesis Technologies for Reactive Systems Software Engineers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The design and development of open reactive systems, which compute by reacting to ongoing stimuli from their environment, and include, for example, mobile applications running on smart phone devices, web-based applications, industrial robotic systems, embedded software running on chips inside cars and aircraft, etc., is a complex and challenging task. Despite advancement from low-level assembly languages to higher-level languages with powerful abstraction mechanisms, and the use of automated testing and formal verification, reactive systems software development is still a mostly manual and error-prone iterative activity of coding and debugging.A fundamentally different alternative approach to reactive systems development is synthesis, the automatic creation of correct-by-construction software from its specification.  Synthesis has the potential to transform the way open reactive systems software is developed, making the process more effective and productive, and making its results more reliable and usable. However, while important advancements have been recently made on the algorithmic aspects of synthesis, no work has yet taken advantage of these achievements to change software engineering practices from “program centric” to “specification centric”. No effective end-to-end means to use synthesis are available to engineers, and the potential revolutionary impact of synthesis on the engineering of reactive systems software is far from being fully explored.  The proposal targets four objectives: a new, rich specification language, tailored for synthesis and for use by software engineers; a set of new methods for specification centric development; tool implementations in ‘killer app’ application domains; and systematic evaluation with engineers. The research aims to unleas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pre-clinical development of a lentiviral gene therapy to treat hearing and balance loss in Usher 1B patients' (MY-O-SENSES) under Horizon Europe.

assistant: **Objectives**

The most prevalent genetic sensory defect, sensorineural hearing loss (SNHL), affects >430 million people and results in substantial financial and social consequences. Current treatment options are limited, achieving only temporary or partial relief and are restricted to a sub-group of patients. Therefore, novel treatment options are of high clinical need. Genetic mutations play a role in the majority of SNHL cases, which makes SNHL an ideal setting for innovative clinical gene therapy approaches. Usher syndrome is an especially severe form of SNHL, with loss of vision and balance accompanying the profound deafness.  The size of the underlying genes, mutations of which are causative for Usher syndrome, exceeds the cargo capacity of gene therapy vectors currently employed to treat inner ear disorders. In my ERC-funded consolidator project iHEAR, we have provided the first ground-breaking evidence of efficient gene transfer into inner ear cell types using beyond state-of-the-art lentiviral vectors (LV). As these LV have the capacity to deliver large genetic payloads, we acquired initial data demonstrating functional improvement in a knock-out mouse hearing loss model following LV application. The MY(O)SENSES PoC proposal aims to advance these valuable research results towards clinical application by completing pre-clinical development, securing IP rights and commercializing a formulated medicinal product to launch a first-in-human clinical LV gene therapy trial to treat Usher syndrome patients. This ground-breaking concept can be extended to treat late-onset hearing loss in patients with heterozygous mutations and can be transferred to similar diseases with a genetic or acquired cause. The MY(O)SENSES product will be the first and only treatment that addresses the debilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Semiconductor Equipment Assessment Dissemination' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

An effective organisation has been established for the independent monitoring, results analysis and global dissemination of all aspects of SEA. SEAD will continue these activities whilst enhancing its multi-faceted dissemination paths across the expanded range of E&M projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordinating Action Systems Medicine – Implementation of Systems Medicine across Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of CASyM is a combined large scale effort to sustainably implement Systems Medicine across Europe. For that purpose CASyM will function as a managing and coordinating platform in bringing together a critical mass of relevant European stakeholders such as Systems Biology scientists, clinicians, programme managers, industry/SMEs as well as healthcare providers and patient organizations. The goal of that initial nucleus of experts is the development of a strategy to implement the Systems Biology approach into medical practice and research within the 4 years duration of CASyM. For this purpose it is essential that the involved communities build a vision and coordinated strategy. Our joint effort gathers extensive experience in the coordination and realization of such a new, large-scale European effort, thereby providing the basis for an advanced future medicine. The output of CASyM will be a conceptual framework defining the remits, milestones, mechanisms and metrics for the implementation of Systems Medicine. The development of this framework will overcome competitive barriers and proceed to produce a European roadmap for Systems Medicine as concerted project result.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms of epigenetic inheritance by short RNAs' (RNAEPIGEN) under Horizon 2020.

assistant: **Objectives**

Epigenetic mechanisms are considered to be central to the development of multicellular organisms made of different cell types, all having identical genomes. Similarly, they may explain how genetically identical organisms are capable of adapting to distinct environmental conditions. Yet, the molecular mechanisms regulating how epigenetic traits can be inherited during cell division or across generations are not fully understood. Using the nematode Caenorhabditis elegans, we have recently revealed how the nuclear Argonaute protein CSR-1 and its associated short RNAs participate in global transcriptional regulation and chromatin organization. This unprecedented observation opened up a new class of molecular mechanisms by which Argonaute proteins and their bound short RNAs may actively contribute to epigenetic inheritance in animals.This research proposal focuses on the characterization of short-RNA-based mechanisms of epigenetic inheritance during animal development and upon environmental changes. Using C. elegans as an animal model system, we plan to integrate genetic, biochemical, and molecular biology tools with high-throughput genomic and proteomic approaches to dissect (i) the molecular mechanism by which CSR-1-bound short RNAs regulate transcription, (ii) test their ability in propagating the memory of actively transcribed genomic regions during early embryonic development, and (iii) characterize their role in propagating the memory of stress responses across generations to facilitate the adaptation of animals to environmental changes.Given the association of nuclear Argonaute proteins with transcriptionally active loci in metazoans, we anticipate that similar CSR-1-like epigenetic functions are also conserved in humans. Therefore, our research has the potential to s