RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'FGF-regulated miRNAs and their roles in skin inflammation and cancer'.

assistant: **Concept**

Skin cancers are the most common types of cancer in the caucasian population, and their incidence has reached epidemic proportions. In addition to skin cancer, inflammatory skin diseases are also extremely common. For the development of novel therapies for skin diseases it is essential to unravel the mechanisms that regulate skin homeostasis and pathological alterations. Recently, the host laboratory made the surprising observation that fibroblast growth factor receptor (FGFR) signalling has a tumor-suppressive function in the epidermis, since loss of FGFR1 and FGFR2 in mouse keratinocytes resulted in the development of skin inflammation, followed by spontaneous formation of carcinomas. The goal of the proposed project is to unravel the mechanisms underlying the functions of FGFRs in the epidermis with a particular focus on micro-RNAs (miRNAs). These small RNAs are emerging as new key players in the regulation of cancer-associated pathways in various tissues. However, FGF-regulated miRNAs in the skin remain to be characterized. FGF-regulated miRNAs and their targets will be identified starting from a combination of miRNA and mRNA profiling of RNA samples from epidermis of control and FGFR mutant mice at different stages of postnatal development and of tumors. Preliminary bioinformatic analysis already identified 5 miRNAs that show significant differences in expression between mutant and control mice. Accordingly, the expression level of more than 300 mRNAs was altered. Based on these data, we will identify those miRNAs that are expressed in keratinocytes in an FGF-dependent manner and we will characterize their functions and the relevant targets in cultured keratinocytes and in normal, inflamed and tumorigenic skin in vivo. Since miRNAs have already been proven to be va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The future of research on aquaculture in the Mediteranean Region' (AQUAMED).

assistant: **Concept**

The fast development of the Mediterranean aquaculture (freshwater, marine) is confronted to a set of difficulties e.g. inadequate production systems and competitiveness, interaction and space competition with other users and the need for a proper integration in the coastal zones, possible negative impact on the environment and negative image of the product quality. Aquaculture development in the Mediterranean countries is contrasted in terms of importance of the sector, domestic market demand, typology of the industry, and research and development structures and capacities. Consequently, a strategy for a knowledge-based development of the activity has to be implemented using a flexible and concerted approach. To deliver practical results, the AQUAMED project will be based on a four step process consisting in (1) mapping and setting a database of all relevant information (about policies, research and socio-economy) in each partner country, (2) identifying common situations and constraints between countries, (3) grouping countries confronted to similar driving forces in order to foster information exchanges and formulate more focussed science based recommendations and (4) setting up of a multi-stakeholder platform to promote a research organisation and an revolving implementation plan aiming at the sustainable development of aquaculture. The platform will be organised to be self-sustainable after the end of the project. It will be instrumental to rationalising research programming in order to avoid duplication, fragmentation and dispersion of research efforts, and to stimulate a long-term cooperation and coordination among policy makers, aquaculture industry and RTD performers in the Region. The Project consortium, covering most of the situations of the aquaculture sector
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanoscale Materials for Energy: Fundamentals, Applications and Safety""' to be submitted under Seventh Framework.

assistant: **Abstract**

One of Humanity’s most urgent and greatest scientific and technological challenges is the need for more efficient methods to access renewable energy sources and ways to reduce energy consumption. Nanotechnology opens up fundamentally novel routes to address these challenges. With focus on the unique opportunities offered by III-V nanowires and molecular engineering, PhD4Energy will develop (i) highly-efficient, cost-effective, and flexible NW solar cells, (ii) cost effective, phosphor-free LEDs for RGB and lighting with optimised color rendering index and very low energy consumption , (iii) practical methods to enhance the thermoelectric performance of nanomaterials, and we will (iv) pioneer the use of Nature’s choice of material (proteins) for direct chemical-to-mechanical energy conversion in artificial molecular machines. Furthermore, PhD4Energy will concurrently evaluate the safety and sustainability of our novel nanomaterials and device fabrication. In order to train early-stage researchers in the skills and methods necessary for succeeding with the proposed research and its industrial applications, PhD4Energy builds an innovative doctoral program (IDP) that with 9 partners from the private sector, combines high-level, interdisciplinary research with an extensive secondment program. The IDP will be designed to last beyond the tenure of PhD4Energy, and will serve a best-practice model for PhD education that effectively bridges the gap between academic research and in-terest of commercialization. A key feature of the training program is the direct input of industry leaders on the students’ course menu, greatly enhancing employability. The training program will be embedded into the major materials science research hub at Lund in Sweden, comprising of the Nanometer Str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Researchers in Action for Inclusion in Science and Education' (RAISE) targeting Horizon Europe.

assistant: **Abstract**

Researchers in Action for Inclusion in Science and Education (RAISE) aims to reach members of society that continue to be left out or feel detached from science. It is built around an original concept of co-creation that will harmoniously blend the European Researchers Nights (ERNs) activities with the Researchers at School (RAS) activities, making the ERN feel like a continuum of the RAS programmes. Towards this end, RAISE is structured around two science outreach and education RAS programmes (named Cientista Regressa  Escola and Cincia di Noz Manera) that will target close to 2,500 underserved and/or underprivileged school students, and two editions of the ERN that will be held at the outstanding Champalimaud Centre for the Unknown (CCU) and live-streamed, reaching an additional 3,000 people in Portugal and through Portuguese as well as other relevant languages. Working at the national level, our original approach will result in ERNs programmes that are immersive experiences co-created by the researchers and the public rather than designed and delivered by the researchers for the public. Thanks to the evidence-based methodologies that will be applied and our culturally responsive co-production approach, sustained collaborations and partnerships between European or Europe-based researchers and school students, teachers, artists and members of the public at large will be created, contributing to a more inclusive and diverse landscape in science and education, and a more scientifically literate society in Portugal. Importantly, RAISEs activities will be developed around the motto RAISE for Wellbeing. RAISE for Social Impact.'' and they will be connected to all the five EU Missions through the RAS programmes and specifically to the Mission on Cancer at the ERNs.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Redistribution and activation phenomena in integrated circuit and device manufacturing' (RAPID), addressing dissemination and exploitation.

assistant: **Impact**

The RAPID project aims to achieve major advances in understanding and modelling of such non-equilibrium phenomena.Up to now, development of process simulation models in Europe has been done in a largely piecemeal way. Academic institutions have typically focused in isolation on specific physical aspects, while industry has concentrated on modelling processes currently under development. Where industry has funded academic research, this has produced focused solutions that succeed at the point of delivery but do not address future (or other) technology problems. This cautious and pragmatic approach has limited the development of predictive models and simulation tools.The project will avoid these limitations and bring together specialists in solid-state physics, materials science, and electronic engineering, with extensive experience in mathematical modelling and computer simulation, as well as processing and measurement of silicon devices. By a unique combination of experimental techniques basic physical issues on defects, diffusion and electrical activation will be addressed in a synergistic way, relevant to all future silicon-based devices. Based on these experiments, a physically motivated model will be developed and benchmarked against dopant profiles and electrical data of sub-micron devices. Key results from the project will be implemented into TCAD tools used by industry. This procedure has become feasible now that physics-based simulators such as SUPREM-4 are commercially available. In this way, RAPID will contribute to the reduction of times needed and costs incurred in the development of novel ULSI devices. Efficiency is further increased by shifting the effort on software development to the commercial suppliers, with appropriate safeguards on access to the mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Designing nanoadhesive keys to manipulate cell adhesion and signalling' (CELLADHESIVENANOKEYS) targeting Sixth Framework.

assistant: **Abstract**

Cell-cell and cell-extra-cellular matrix (ECM) adhesion are complex, highly regulated processes that play a crucial role in most fundamental cellular functions including motility, proliferation, differentiation and apoptosis. Focal adhesions are major cellular sites responsible for cell-ECM attachment and adhesion-mediated signalling.These complex multimolecular assemblies consist of transmembrane integrin receptors that are linked to the actin cytoskeleton via cytoplasmic anchor proteins, such as vinculin, paxillin and focal adhesion kinase. To study the function behind molecular arrangement of single integrins in cell adhesion, we will design rigid template of cell adhesive gold nano-dots coated with cyclic RGDfK peptide by lithographic means of diblock co polymer self-assembly.The diameter of the adhesive dots is smaller 8 nm, which allows the binding of only up to one integrin per dot. These dots are positioned with high precision on a molecular scale at a controllable separation distance between 10-150 n m in different but defined pattern geometries.Because the dots may only be occupied by up to one integrin the dot pattern also resembles the integrin pattern in focal adhesions. We will study how the chemical nanoadhesive template effects cell spreading and shape, adhesion forces and expression of Fibronectin and Collagen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Specificity Drift in The Kinome During Cancer Development and Evolution' under Seventh Framework.

assistant: **Concept**

Cellular signaling networks have evolved to enable swift and accurate responses, even in the face of genetic or environmental perturbation. While we can readily assess dynamics in phosphorylation sites, our ability to model and predict the associated networks of kinases are hampered by the fact that we lack information on catalytic specificity for around 60% of the 538 human protein kinases (kinome). This translates into an even bigger gap in kinase-substrate relationships, where a phosphorylating kinase is only known for 20% of all known phosphorylation sites. The importance of closing these gaps is underlined by the fact that kinases are the target of about 75% of current world-wide drug development programs, and it is increasingly evident that they must be targeted in combinations, as elucidated by network models.While genomic studies are revealing large numbers of mutations in kinases in most cancers, algorithms that can assess which of these are important for tumor growth and disease progression are missing. Thus, there is a critical need for algorithms that can predict how such lesions affect the catalytic specificity of kinases. These challenges must be resolved before we can predict how combinations of genetic alterations affect networks and thereby drive complex phenotypes and diseases.The main objective of this grant is to explore the specificity space of kinases through a combination of experimental and computational approaches. We shall investigate how specificity in cellular signaling systems may be altered during both natural evolution and cancer development. We will develop a new generation of network biology algorithms to enable interpretation of mutations in the kinase domain. In combination with semi-automated specificity and mass-spectrometry interact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NEAR2050 - future challenges for the rail sector'.

assistant: **Innovation**

This project NEAR2050 will analyse and take in to account developing technologies, new societal trends, and changing demographics among others in order to obtain a full account of what users currently need and expect from the rail sector and what they will need and expect from the rail sector based on mega trend based scenarios in 2022,2030 and 2050.NEAR2050 will analyse the entire process that needs to be gone through by both passengers and freight. This will look at the door-to-door offers as well as what planning options exist for customers. Investigations will be carried out as to what can be put in place to overcome the obstacles uncovered in the previous stage. These will range from “quick wins” and easy to implement ideas, to long term plans that require investment over numerous years.Using the future needs determined over the course of this project, NEAR2050 will look at what each of the actors can implement how difficult implementation will be, and will make recommendations of implementation plans.NEAR2050 will look at other mobility modes, make a determination of their development over the time scenarios and with that make a determination as to the type of cooperation that will be required and how this can be implemented. This can include interaction with busses, shared and private bikes, shared and private cars. The analyses will look at the opportunities of shared ticketing, booking, and pricing systems, and the availability of these mobility modes among others.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pheno-connectomics of human neurodevelopmental diseases' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is much we don't know about how neurons connect in our brains, but we know that their connectivity is essential for brain function in health and disease. Many psychiatric diseases coincide with the miswiring of the brain: to understand these, we need to know how neurons connect in each condition. I will develop a new approach to map single-cell synaptic connectivity, and use it to study joint connectome & transcriptome changes in an established monogenic autism spectrum disorder (ASD) organoid model. Change in synaptic connectivity is a key feature of ASDs, such as Rett-syndrome, which is caused by a mutation of the epigenetic regulator, MECP2. To understand how Rett-syndrome manifests on both transcriptional and connectivity levels, I will compare healthy & MECP2-KO human cortical organoids. I will combine single-cell mRNA sequencing and transsynaptic viral tracing techniques with barcoding. I will subsequently develop the required computational analysis entailing multi-omics integration and network analysis, and use statistical reconstructions to study the global properties of the organoid connectome. In essence, the project aims at four advances: Technology: – Develop a connectome-by-sequencing assay to chart synaptic networks of thousands of neurons.Basic biology: – Find out how many, and what kind of connections do single neurons form? – Do ‘lonely’ neurons have a different transcriptome than highly connected ones?Concept: – Introduce single-cell connectomics as a phenotype (pheno-connectomics) to understand diseases, and find their earliestmanifestation.Disease mechanism: – How genetic defects affect gene expression, and concurrently the connectome? – Are all cell types affected the same way?


**Keywords:** Connectomics,  Transsynaptic tracing,  Single-cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Deformations of fundamental Groups of REpresentATions'.

assistant: **Concept**

The aim of this project is to consider X a smooth projective algebraic curve and a representation ρ of π1(X) into a semisimple Lie group G, and study deformations of ρ when X deforms into a singular curve. This question will open a brand new direction in the theory of representations of fundamental groups and G-Higgs bundles. The main tool to approach the problem will be non- abelian Hodge theory to transform this topological question into the geometric one. Then we use recent new developments in the classification of representations together with new algebraic objects which recently appear in non-abelian Hodge theory to study this question. It will take us to the study the deformations of G-Higgs bundles together with deformations of harmonic bundles over X when X is a curve and varies.This project will allow the researcher to broaden her area of expertise as well as to develop new directions in her research lines. She will complement her knowledge in differential geometry in one of the most prestigious Universities and under the guidance of one of the worldwide leaders in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Biogeomorphodynamic model of Estuaries for the analysis of effects of human interference'.

assistant: **Innovation**

Estuaries are important for economy and nature. Due to the relatively calm conditions where land meets the water, they are good locations for harbours and are safe havens and feeding grounds for wildlife. These qualities collide in the Western Scheldt. Dredging is required to enable navigation to Antwerp Harbour, but it endangers the stability of the shoals that are important to ecology. The interactions of the bed and the water flow over it shape the estuaries. The bed determines the flow of the water. In turn the water moves sediment resulting in bed changes. Stability analysis has shown that this feedback mechanism allows free instabilities to grow into a channel-shoal system. The essential processes for the morphology of estuaries are identified, but the long term dynamics of can only be modelled in idealised cases. Moreover, the problem is more complex. Sediment with much clay is cohesive; sediments with little clay are cohesive. The differences in stability of the sediment strongly influence the shape o f the shoals. Moreover, it has been shown that biology affects the morphology. Some organisms stabilise the bed, others have a destabilising effects. It is unclear yet, how these effects change the morphology of the channels and shoals. Cellular automata a re models that combine the essential mechanisms of a system with the freedom of randomness. The equations describing the essential processes make sure that the correct physics are simulated, while the random element allows free instabilities to grow. In this project the cellular automata approach is used to apply the existing knowledge gained by the stability analysis to existing estuaries. For this purpose the model parameters must be set correctly. Since many of the individual processes can not be measure d, th