RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From single neurons to visual perception' (NERVI) targeting Seventh Framework.

assistant: **Abstract**

We propose to develop a formal model of information representation and processing in the part of the neocortex that is mostly concerned with visual information. This model will open new horizons in a well-principled way in the fields of artificial and biological vision as well as in computational neuroscience. Specifically the goal is to develop a universally accepted formal framework for describing complex, distributed and hierarchical processes capable of processing seamlessly a continuous flow of images. This framework features notably computational units operating at several spatiotemporal scales on stochastic data arising from natural images. Mean-field theory and stochastic calculus are used to harness the fundamental stochastic nature of the data, functional analysis and bifurcation theory to map the complexity of the behaviours of these assemblies of units. In the absence of such foundations the development of an understanding of visual information processing in man and machines could be greatly hindered. Although the proposal addresses fundamental problems its goal is to serve as the basis for ground-breaking future computational development for managing visual data and as a theoretical framework for a scientific understanding of biological vision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disrupting Orthotics and Prosthetics Market with Open Digital Platform' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Custom-made orthotic and prosthetic (O&P) market grows rapidly as the global population ages and suffers from civilisation diseases. In the next 10 years the O&P industry will be disrupted by digital economy (automatisation, 3D printing and 3D scanning). Due to rising costs of O&P products and patients’ demand for improved comfort, function and aesthetics, every third O&P product will be 3D printed by 2027. However 3DP products need to be custom designed and that is costly, know-how & time demanding. With our proprietary technology and 25 years experience in the O&P market, Invent Medical set to become the Uber in orthotics and seize this market share with the Open Digital Platform by leveraging 3rd parties and automating & democratising the whole process in an ultra scalable and affordable way. We are offering benefits of digitalisation to medical facilities to improve people’s life worldwide as custom-made orthoses and prostheses are the only effective solution in a treatment of difficult injuries, deficiencies and civilisation diseases.The goal of Phase 1 of the project is to assess the feasibility of the Open Digital Platform business model. Activities will be focused on advanced Market analysis, IP research, Licensing of products, a Business Plan preparation and Pilot tests. Pilot testing of the platform will be conducted on two product lines to verify viability of the platform and cooperation with 3rd parties providing sales & support, manufacturing and computing. The project will have an impact on the global market due to global availability of a new generation of 3DP O&P products. Our disruptive business model complies with the EU strategy in healthcare to promote good health and healthy ageing by developing innovative solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fincam' (1998-2002).

assistant: **Concept**

The workshop aims at analysing the so far still unsolved and ever growing problems of violations of personality rights by the media. Concrete European solutions are to be formulated. The workshop will appear as part of a European-wide effort towards a common protection of personality rights. The subject will be approached and investigated from all the relevant points of view of the fields involved. The workshop will be held at the course of three days.On the first day the theoretical foundation to the subject will be set out by representatives of the areas of civil law, criminal law and science of the media. This will give the multidisciplinary background to all the participants. The second day will give an overview on the European and international state-of-the-art. On the third day the workshop will highlight the practitioners contrasting points of view. The schedule of the workshop allows for extensive discussions and enables especially the young researchers to get in touch with the keynote speakers. Greifswald as sight of one of the oldest German universities was chosen as a location for the workshop because it is situated in the centre of Europe regarding the newly achieved extension of the European Community to Scandinavien countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tunning the force for remote magnetomechanical gating of Piezo1 channels' (MAGPIEZ), addressing dissemination and exploitation.

assistant: **Impact**

During the last decade, the possibility to remotely control intracellular pathways using physical tools has opened the way to exciting applications, both in basic research and clinical applications. The use of magnetic fields in combination with magnetic nanoparticles provides with an exclusive tool to study how cells transform mechanical stimuli into biochemical signals, shedding light on these mechanotransduction processes. This tool is emerging as a new instrument to remotely manipulate biological functions with high spatiotemporal control at a deep-tissue level, a hot topic in regenerative medicine. The overall aim of MAGPIEZ is to develop a novel platform to study mechanotransduction linked to Piezo1 channels in endothelial cells by remotely manipulating magnetic nanoparticles. A secondary goal is to validate the potential of this tool to stimulate signalling pathways related to cell proliferation in order to selectively boost angiogenesis. This can stand as a promising approach for therapeutic angiogenesis in ischemic disorders. This ambitious project will be validated using 2D endothelial cells and a 3D vascular network developed using a microfluidic chamber. MAGPIEZ is a highly multidisciplinary project that takes advantage of the Fellows Dr. Del Sol knowledge in Materials Science (advanced synthesis and characterization of magnetic nanoparticles, magnetism and physics) and the expertise of the host group supervisor (Dr. M. Moros, Institute of Nanoscience and Materials of Aragon INMA-CSIC) in biofunctionalization of nanoparticles and magnetogenetics. This project will offer the applicant the possibility to work in a top European institution who pioneered the use of nanomaterials for biomedical applications, and to develop new skills and knowledge necessary for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The origin, distribution, and dissemination of the apple microbiome' in the context of a Horizon 2020 call.

assistant: **Objectives**

The success of any agricultural system and sustainable production depends on the health of its plants. Pests and pathogensare responsible for the loss of almost one-third of the global crop production. However, microorganisms found in and onplants are not always the cause of disease. Instead, the naturally occurring microbial communities, the plant’s microbiome,play an essential role in the development of healthy plants. This project is based on a hypothesis-driven approach to addressfundamental questions about the plant microbiome such as What is the source of a plant’s microbiome? What are thepathways of inheritance and acquisition? How does the microbiome move, disseminate, and enter a new host? Apple wasselected as a plant model; a fruit that has been a principal component of a healthy diet, and played a major role in humanevolution and survival. The proposed methodology employs cutting-edge and multidisciplinary techniques such asmetagenomics, transcriptomics, and metabolomics, among others. Results of this project will help to understand themicrobiome’s life cycle, associate microbes with specific organs and tissues, and identify microbial species that define ahealthy host with healthy organs and offspring. From there, it will be easy to determine changes, understand disease anddisorders, and find ways to correct unbalanced microbiomes. Identifying how the microbes are acquired and to which organsand tissues they are associated with, will help in understanding the optimal methods to introduce microbial species to thehost. While the proposed approaches are novel, once the validity of the hypotheses is proven, they will serve as a foundationfor future microbiome studies. These studies will drive the development and implementation of safe, environmentally-friendlystr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanomedicine: an integrative approach' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nanomedicine (NM) is regarded as one of the most promising applications of nanotechnology, as it would allow the development of tailored therapies, with a high level of selectivity and efficacy. Although much research has been performed over the past decades, translation from academia to commercial application remains disappointingly low. Reasons that explain the current moderate success of NM are: (1) promising preclinical results are often poorly predictive for clinical safety and effectiveness, (2) the efficient, scalable and reproducible GMP production of nanocarriers has proven to be challenging and (3) regulatory frameworks are not yet fully equipped to efficiently facilitate the introduction of novel nanomedicines. These obstacles are often encountered since the developmental process from carrier design to clinical assessment is performed by a range of scientists from different backgrounds who have difficulty interacting and communicating with each other to clearly understand the necessary design criteria and the scope and limitations of NM.NANOMED brings together all the necessary expertise to oversee the entire development trajectory required for NM. This is achieved by the combined effort of 7 beneficiaries from academia and industry and 5 non-academic partner organisations, which are all thoroughly rooted in nanosciences and pharmaceutical sciences. Our objective is to develop scalable and highly controllable design and synthesis methods for the most promising nanomedicine types in a preclinical setting. NANOMED will train the next generation of NM scientists by offering an extensive joint training programme to 15 incoming ESRs. It focuses on promoting scientific excellence and exploits the specific research and commercial expertise and infrastructure of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A novel ulcerative colitis treatment - A phase III ready feasibility study' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

InDex Pharmaceuticals AB is a pharmaceutical development company based at the Karolinska Institutet Science Park in Stockholm, Sweden. The company´s primary asset is cobitolimod, which is in late phase clinical development as a new medication to treat moderate to severe active ulcerative colitis (UC); a chronic, debilitating disease with a high unmet medical need. UC is caused by chronic inflammation of the colon, and there is no cure. Cobitolimod offers a novel and unique mechanism of action for the treatment of UC, and has demonstrated a higher efficacy and better safety profile in clinical studies than what has been reported for currently approved biological drugs. Cobitolimod is part of the broad InDex portfolio of DNA-based ImmunoModulatory Sequences (referred to as DIMS), which have the potential for treatment of various immunological diseases. Cobitolimod is currently being tested in a phase IIb clinical study with top line results expected in Q4 2018. InDex’s business strategy is to out-license cobitolimod to a larger international pharmaceutical company prior to the initiation of clinical phase III development. This will generate revenues for InDex from upfront and milestone payments as well as royalties from third party sales, which can then be reinvested in the company to finance development of new compounds from the DIMS technology platform.For clinical phase III, additional manufacturing and toxicology work as well as commercial preparations are essential. The planning and preparation of this work is the purpose of this feasibility study, which is a crucial part of the cobitolimod phase III ready programme, increasing the attractiveness of the asset in partnering discussions with pharmaceutical companies looking for innovative new products. A licensing deal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Constitution of a European inter-territorial network Living Labs for the applications of satellite technologies' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ultimate objective of this project is to explore the possibilities to make emerge a European Cluster of research, build on the basis of a network of public and private agents working on various rural territories in the European Union. These change agents meet around a common will to develop in their zone of action the concept of Living Labs. The methodology which consists in structuring the partnership working up to territories of scientific and economic experimentation goes to the ultimate goal, i.e. the constitution of a European inter-territorial network of Living Labs for the applications of satellite technologies. As a corollary of this concept stands the idea of a network of strategic orientation,a particular structuring of the relationship prevailing between the various partners of the Living Labs. The Living Labs is designed to be an instrument performing the adaptation to the structural changes tested by the local economy. It must make it possible to give the day to a new dynamic and competitive knowledge economy, based on the ability to experiment, on the scale of the territory, research and technological development projects whose strong potential of valorization depends on the transferability of the results towards the regional companies (mainly SME). At the same time, it promotes these companies to join the dynamics of research activities. The concept of Living Labs answers the difficulty for the economic agents to move from a technology push" approach, initiated by the research, to the one consisting in promoting their supply with new services as an answer to a demand. The Living Labs, through a function of demonstrator, aims to create the conditions of emergence of a market demand and to initiate a "technology pull" dynamics for new usages."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Engineering fungal laccases by directed molecular evolution and semi-rational approaches: application in bioremediation of polycyclic aromatic hydrocarbons (pahs)' under Sixth Framework.

assistant: **Concept**

The current research proposal claims to carry out the technology of the enzymatic bioremediation of polycyclic aromatic hydrocarbons (PAHs) by using biocatalysts (both native and tailored by directed molecular evolution). PAHs are a class of highly dangerous xenobiotics widely distributed in terrestrial and aquatic environments.Last trends in PAHs removal address to combine chemical and biological approaches for remediation of these persistent contaminants. However, high molecular weight PAHs cannot be successfully metabolized by neither autochthonous populations nor genetically manipulated bacteria, both under in situ and ex situ applications. In this context, the only organisms known to oxidize efficiently high molecular weight PAHs are the white rot fungi.Many shortcomings have hindered the application of such organisms in large-scale bioremediation processes. Laccase is the one of the most promising and versatile biocatalyst in PAHs oxidation. This proposal deals with the use of laccases in PAHs detoxification from sea spills and wastewaters. The dependence of redox mediators and the instability of laccases are the main hurdles for a practical application.The study of laccases in PAHs detoxification will be tackled by:- Biocatalyst engineering by directed molecular evolution to improve the enzyme stability against organic solvents.- The enhancing the redox potencial of lacccases will mean the increasing in the PAHs oxidation. The construction of combinatorial libraries by saturation mutagenesis will be performed to enhance the laccase ionization potential.- The biocatalyst will be immobilized on acrylic supports and used in a fixed-bed bioreactor to be tested with waste-waters contaminated with PAHs.The objectives of this Project are relevant to two of the activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regional mobility infrastructures' (REMOBILISE).

assistant: **Concept**

REMOBILISE will be the first, interdisciplinary study examining the relationship between mobility infrastructures and free movement in West Africa. In bridging legal studies, citizenship studies, and infrastructure studies it aims to unpack how mobility infrastructures impact free movement in West Africa – and with what consequences. Free movement is recognised as a key driver for economic development, poverty reduction, and livelihood strategies. The Economic Community of West African States (ECOWAS) was among the first organisations to introduce a regional free movement regime in 1979. Yet, immense disparities continue to exist in terms of who can access this seemingly equal right in practice. Although studies have indicated that legal, technological, and physical impediments may result in variegated access to free movement, there remains a lack of knowledge on the impact mobility infrastructures have on free movement. The project seeks to address this knowledge gap through the study of three complementary work packages focusing on the research questions on manifestations, patterns, and consequences of mobility infrastructures. It will use a mixed method approach, innovatively combining ethnographic approaches with legal research and large-scale data analysis. The project contributes to key debates in legal studies, citizenship studies, and infrastructure studies, specifically by improving the emerging scholarship on mobility infrastructures. The findings have direct impact on the lives of over 400 million people living in the region, on the work of ECOWAS policymakers, and on external partners, such as the UN and the EU.


**Keywords:** ECOWAS; Citizenship; mobility infrastructures; free movement; data analysis