RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Randomness and Computation' (RAC) under Seventh Framework.

assistant: **Objectives**

This project is concerned with the necessity and availability of randomness in computation. This research area (often referred to as the ""Theory of Derandomization'') is one of the most active and exciting areas in theoretical computer science. We intend to study some of the main questions of this area: In what setups can randomized algorithms be efficiently simulated by deterministic ones? In cases that randomness is essential, how can computers obtain random bits? More specifically, how can computers generate secret random keys for running secure cryptographic protocols? Furthermore, once random keys are generated, how can computers maintain the secrecy of their keys in the presence of side-channel attacks? These are important real-world problems and our research is intended to lay the theoretical foundation for achieving actual solutions.Our main approach for these problems is to design ``pseudorandom generators'' and ``randomness extractors'' that are efficient algorithms that manipulate randomness in various ways. The PI is one of the leading figures in this research area and many of the concrete research directions suggested in this proposal are related to and build on past work of the PI.The goals outlined in this proposal are important open problems in this area. Some of them (such as derandomizing bounded memory randomized algorithms and constructing 2-source extractors and dispersers for low min-entropy) are famous longstanding open problems and solving either of them will be a dramatic breakthrough in theoretical computer science. We suggest concrete (and we believe novel) approaches to attack these problems. Along the way we identify important and accessible intermediate goals.In addition to the development of the theory of derandomization, past work in thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pneumococcal phages as vehicles of virulence' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The study and characterisation of Streptococcus pneumoniae bacteriophages has been hampered, mainly, due to the technical difficulty to visualise the plaques of phages and to obtain mutants. The CIB lab in Madrid has been able to study, in great detail, the characteristics of four groups of pneumococcal phages, including the whole sequencing and functional organisation of Cp-1 phage, carried out recently. On the other hand, the capsular polysaccharide is the main virulence factor of pneumococcus, and phages capable to infect pneumococcal encapsulated strains have not been described up to now and its isolation would bring about advantages with respect to the putative degradation of the pneumococcal capsular polysaccharides through appropriate enzymes. Isolation of these phages constitutes the main aim of this project. We also plan to carry out a systematic analysis of Iysogenic strains in order to correlate the most relevant clinical pneumococcal strains with the presence in these strains of temperate phages. Furthermore, we plan to study the Iysis mechanism of phage omega2 which presents peculiar characteristics compared to the other pneumococcal phages. Training content (objective, benefit and expected impact) The proposed work dealing with Streptococcus pneumoniae bacteriophages present a number of advantages. The thematics developed in this work and during my thesis are related enough so that I can be rapidly efficient in the research project. Nevertheless, the general domains are very different (medical, _nology). This would lead to greatly widening my initial formation. The study of the Iysis system has beer initiated during my thesis for an _nococcus _ni phage. The proposed work allows to increase the knowledge of such system. The C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Interfirm Networks and Cluster Development:An Empirical Cross Comparison of UK and Italy'.

assistant: **Objectives**

Geographical clusters have long been at the center stage of the debate on interfirm networks and regional success. While research in this field has contributed crucial insights to the understanding of interorganizational networks and embedded ties as deter minants of local growth and systemic strength, much weaker focus has been placed on the role and performance of the cluster-located firm (CLF), as an active constituent of this dense multirelational system. Furthermore, despite the great emphasis on relati onal processes that distinguish research on localized industries by and large, only few studies have endeavored to untangle such processes within a framework of formal network analytic measurement and operationalization. In addressing these shortcomings, t his proposal will attempt to contribute three novel insights to the understanding of firm performance within geographical clusters: First, building on the notion of interorganizational networks as carriers of information and knowledge, it will develope a s tylized model of network ties as enablers of opportunity discovery and CLFs growth. Second, based on social networks analytic tools, it will investigate and provide visual representations of the interorganizational space in which CLFs are embedded. Third, it will provide an original operationalization approach to gauge and statistically estimate the impact of interfirm networking on the economic performance of the CLFs. To underpin these ideas I will collect and use a cross comparision of longitudinal data gathered on a large sample of small firms located in two knowledge intensive geographical cluster, in Italy and UK.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CmOs Solutions for Mid-board Integrated transceivers with breakthrough Connectivity at ultra-low Cost'.

assistant: **Concept**

The COSMICC consortium gathers key industrial and research partners with world-leading positions in the fields of Silicon photonics, CMOS electronics, Printed Circuit Board-Packaging, Optical transceivers and Data-Centers around a strong vision: mass commercialization of Si-photonics-based transceivers is possible starting in 2019 by enhancing the existing photonic integration platform of one of the partners, STMicroelectronics.COSMICC will develop optical transceivers that will be packaged on-board. Combining CMOS electronics and Si-photonics with innovative-high-throughput fiber-attachment techniques, the developed solutions are scalable to meet the future data-transmission requirements in data-centers and Super computing systems. With performances improved by an order of magnitude as compared with current VCSELs transceivers, COSMICC developed technology will answer tremendous market needs with a target cost per bit that the traditional WDM transceivers cannot meet. The early setting up of a new value chain will enable exploitation of the developed technologies.In a first high reward step-modification of the fabrication platform, COSMICC consortium will achieve mid-board optical transceivers in the [2Tbit/s -2pJ/bit- 0.2€ per Gbit/s]-class with ~200Gbit/s per fiber: the introduction of one process brick (SiN layer) in the photonic process will enable low-cost packaging techniques (up to 2x12 fiber channels) and practical coarse WDM implementation (4 wavelengths with no temperature-control requirements). The built demonstrators will be tested in lab and field environments. In compliancy with the enhanced-fabrication platform, lasers will be developed by heterogeneous integration of III-V material, targeting improved temperature behavior, and doubled-bit-rate payback.A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Opportunistic Approximations to Break the Traditional Efficiency Limits of Flexible DSP Implementations' (OPPORTUNISTIC-DSP) under Seventh Framework.

assistant: **Objectives**

Worst-case design is one of the keys to practical engineering: create solutions that can always withstand all the most adverse conditions that could occur. Yet, the limitations of battery capacity, the slowing progress in CMOS technology energy efficiency, and the ever growing need for more computational power combine into a grim outlook for worst-case design in the future. This becomes even worse, when one considers the exploding non-recurring engineering costs and turns toward programmable systems—an economic necessity in most cases and yet a fundamentally less energy-efficient implementation option. This project pretends to revolutionize the way systems are design today introducing the concept of opportunistic approximations to fundamentally depart from the notion of a single worst-case design point. Opportunistic approximations enable a continuous adaptation of the processing characteristics (operation type, number and precision) to the actual operating conditions. By relaxing the processing load when possible, a significantly increase in the processing efficiency of advanced DSP (Digital Signal Processing) flexible implementations is expected. Particularly, for DSP systems running under highly varying situations. Making opportunistic approximations practical requires the combination of deep knowledge of DSP applications and low power flexible DSP architectures, expertise developed by the applicant during his PhD, with the latest design automation technology, area where the proposed host institution excels worldwide. Thus, enabling opportunistic approximations will result in major reductions of average energy consumption and average processing time while still meeting functional specifications at the input-output interface (e.g., maximal bit-error-rate for a wireles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Earth in Transition: from Earliest Crust to Earliest Preserved Rocks' (HADEAN) under Seventh Framework.

assistant: **Objectives**

Current knowledge of the nature and origin of the earliest crust on Earth comes largely from studies of the mineral zircon. The oldest zircon crystals from Jack Hills in Australia provide a wealth of information and represent a time capsule of what the Earth was like from 4.4 to 4.0 Ga during the Hadean. These zircons are detrital grains preserved in much younger rocks, and no known rocks of this age have survived on Earth. By applying the most up–to-date technologies to various isotopic systems in these zircons, it has been possible to deduce that continental crust and oceans formed early in Earth`s history and that the planet cooled more quickly than was previously realised. The aim of this proposal is to compare the information acquired from these detrital grains with comparable new data to be obtained from the earliest known rocks on Earth. These ancient rocks are preserved in Antarctica, Canada, China, Greenland, Western Australia and Swaziland. Extensive investigation of these rocks will allow us to characterize further the nature of the earliest preserved crust and, more importantly, to document what changes took place from the formation of the earliest zircons (4.4 Ga) to the oldest preserved crust (4.03 Ga) and to evaluate why so few Hadean rocks survived on Earth. This period represents the ‘dark ages’ in terms of Earth history and marks the onset of stable conditions on the Earth that set the stage for a habitable planet.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterizing Function Genetic Variants Linking Immunity and Psychiatric Disorders' (IMAGENE) targeting Horizon 2020.

assistant: **Abstract**

Understanding genetic risk for disease is one of the major goals in human genetics. Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with complex human diseases, the majority of them locating in regulatory regions outside of genes. The identification of functional regulatory variants underlying such GWAS associations and understanding their pattern of activity is the key for understanding biological processes behind each genetic association to disease – and without such understanding, targeted interventions and drugs to affect the relevant pathways are not possible.IMAGENE will elucidate the role of functional genetic variants that link immunity and psychiatric disorders such as schizophrenia. This will be achieved by combining state-of-the-art technologies in genome engineering, Next-Generation sequencing and computational biology, which will allow obtaining mechanistic insight into genetic risk of human diseases at unprecedented depth. The applicant has unique interdisciplinary skills to carry out the project, including clinical background and basic research experience in the different fields united in this proposal – human genetics, immunology, and psychiatry. The impact of the project could be enormous, since elucidating the molecular mechanisms of disease-associated variants that link immune function to disease pathology of schizophrenia could contribute to the development of novel treatments for this disease.


**Keywords:** Genome-wide association studies, eQTL analysis, Toll-like-receptors, Human monocytes, schizophrenia, genome engineering, CRISPR, Cas, RNA-Seq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on '4D bioprinting shape-morphing tissues using phototunable supramolecular hydrogels'.

assistant: **Innovation**

During embryonic development, organs emerge through highly dynamic processes driven by complex shape-transformations that sculpt their final shape, composition, and function. Despite this, existing approaches to organ bioprinting employ static hydrogels that are not capable of supporting morphogenetic shape changes. Further, we lack an understanding of how key morphogenetic forces such as volumetric tissue growth can be leveraged to re-engineer fundamental tissue shape-morphing behaviours such as bending, buckling, bulging, or twisting. These are major barriers preventing the design of bioprinted tissues that undergo shape-transformations essential for their evolution into a functional final form.  Recognising this, the goal of morphoPRINT is to develop a dynamic hydrogel platform that can spatially turn “on” or “off” volumetric growth in bioprinted tissues to direct 4D shape-morphing, and to use this platform to re-engineer morphogenetic shape changes that sculpt the tissue into a more mature form. To realise this goal, we propose ground-breaking technological advances to create hydrogels with independent networks of 1) supramolecular crosslinks that support volumetric growth and 2) photoresponsive covalent crosslinks that can be spatially activated to resist volumetric growth. We will use this platform to explore how spatial patterns of volumetric growth can drive tissue bending, buckling, and bulging, which will lead to a new conceptual understanding of the physical principles that drive tissue shape-morphing. We will then apply these principles towards the design of bioprinted heart tubes that undergo embryonic-like looping into an early 4-chamber structure. morphoPRINT will enable, for the first time, bioprinted organs that undergo programmable shape-morphing. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel roles of dimethylated sulphur in marine microbial interactions' (SUMMIT) targeting Horizon 2020.

assistant: **Abstract**

Sulphur is an essential element for life that cycles rapidly in the pelagic ocean in the form of biogenic dimethylated compounds. Over three decades, dimethylated sulphur has been intensively investigated for its emission to the atmosphere and its suggested roles in returning sulphur to continents and in climate regulation. While the climate connection still awaits definitive confirmation or denial, these research efforts have provided important advances in plankton physiology and ecology, since these forms of sulphur arise from organism adaptation to saline and sunlit waters and are integral to the food web machinery. Previous studies have disclosed biochemical and trophic cycling pathways and their taxonomic affiliations. Also, evidence for their behaviour as infochemicals in organism-organism communication has been obtained. However, their contribution to the functioning of marine ecosystems remains largely unexplored, particularly with respect to the emerging renewed picture of food webs, where classical functional roles blur and concepts like multifunctional organisms and interdependence become the rule rather than the exception. I propose to bridge microbial physiology, ecology and biogeochemistry to explore new roles of dimethylated sulphur in microbial food-web interactions. I will build upon a combination of molecular tools, isotopes, single-cell analyses, physiological dyes, chemotaxis experiments, modelling, sea-going opportunities and an existing collection of samples from diverse oceanic biomes. Hypothesis-driven research is expected to yield paradigm shifts in (i) phytoplankton-bacteria interactions through nitrogen fixation and vitamin exchange; (ii) phytoplankton-phytoplankton interactions to overcome energy limitation to growth; (iii) phytoplankton-herb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SmartHeat – An eco-innovative solution towards zero-carbon household heating' (SmartHeat) under Horizon 2020.

assistant: **Objectives**

SUNTHERM has developed a Worlds first 25 kWh thermal storage compact battery, based on salt hydrate dissolved inmineral oil that enables up to 25 hours of heat displacement (patent pending). SUNTHERM’s game-changer integratedheating system for households - SmartHeat - consists of:- Smart heating and heat storage, provided by a 25 kWh thermal battery (60 × 60 × 200 cm), coupled to a module of cloudbasedmanagement with an online control unit for real-time control over heat management, acting as a buffer in the grid;- Solar thermal collectors, for higher flexibility and 100% zero-carbon, sustainable heat production;- Heat pump, smart grid enabled, providing the management of energy loads - peak load shaving -, the storage of excesspower during low demand periods for release during peak demand periods - load balancing -, and the integrated optimizationof the heat pump operation.SmartHeat can effectively cover normal family's daily needs for radiators, floor heating or hot water, with a heat releasecapacity above any other heating unit available, due to its intelligent and huge storage capacity - equivalent to an oil burnerin a utility room and delivery of twice the amount of hot water than a conventional hot water tank. By storing energy from thesun - or when the power is cheap - in our unique battery and delivering it when the house requires heating, we will offer thehomeowner the opportunity to reduce the heat bill by 75% in comparison to the use of an oil burner, due to 40% increase inefficiency vs. a stand-alone heat pump.Through the successful development and implementation of SmartHeat WWF award winning technology, SUNTHERM willbe in a strong position to exploit a market worth at 34.5 billion € and enhance its profitability by the stream of the sales, withan expected