RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Rational Treatment Strategies Combating Mitochondrial Oxidative Phosphorylation (OXPHOS) Disorders' (OXPHOS).

assistant: **Concept**

Defects in the mitochondria! oxidative phosphorylation (OXPHOS-) system, the principal circuit for cellular energy production, lead to often fatal, multi-system disorders affecting organs and tissues with a high-energy demand. The EUMITOCOMBAT consortium, consisting of 12 partners, encompassing 21 scientific groups from nine different countries, including the Czech Republic, aims to integrate and extend knowledge on basic aspects of OXPHOS biology and the pathobiological cascades underlying OXPHOS disease manifestation in humans.The EUMITOCOMBAT project will re-inforce Europe as the international leader in the development of treatments capable of combating these disorders. To this end we will:- Integrate clinical and model-system expertise.- Characterize important genes and proteins involved in the formation and regulation of the OXPHOS-system.- Study the network of components involved in cellular energy metabolism by functional genomics.- Develop more efficient genetic and protein (mutation) screening methods.- Evaluate the cellular alterations/adaptations of these defects in specified cells, tissues, models and humans.- Develop methods to target and test therapeutic agents to specific (sub)cellular locations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intra-and Inter-Societal Sources of Instability in the Caucasus and EU Opportunities to Respond' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

ISSICEU analyses sources of stability and instability in the Caucasus regarding political regimes, civic participation, economic interdependencies and neighbourhood influences. We evaluate the implications for military, political, economic and societal security.We deliver three relevant products for EU policy formulation: We analyse and map emerging conflicts of local, regional and international dimensions and highlight crucial actors and mechanisms. We elaborate on scenarios concerning potential future security developments. We give concise policy recommendations on opportunities for the EU to influence conflict solution and long-term stability in the Caucasus societies and the whole region.ISSICEU disseminates the findings as follows: policy briefs; expert workshops in relevant EU agencies and for stakeholders in EU countries and the Caucasus; a scenario-workshop at the final stage.ISSICEU explores intra-societal frictions and their regional impact in the political regimes focussing mainly on dynamics of communal governance; the interplay of religious and state actors and practices of civic participation. We analyse inter-societal sources of (in)stability regarding economic dependencies; political and societal relations between the Caucasus and neighbourhood states.ISSICEU makes comparative analyses across sub-regions and studies aspects of inter-societal relations. We consider the historical and contemporary ties among the societies. We study the Caucasus in its diversity and cohesiveness. Cases are Armenia, Azerbaijan, Georgia, Abkhazia, South Ossetia, Nagorno-Karabakh, Dagestan, Kabardino-Balkaria, Karachay-Cherkessia and Chechnya. In the neighbourhood we focus on Turkey and Iran.ISSICEU takes theory-informed, interdisciplinary and strongly inductive approaches, ab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Computational Theory of Haptic Perception' (PATCH) targeting Seventh Framework.

assistant: **Abstract**

During mechanical interaction with our environment, we derive a perceptual experience which may be compared to the experience that results from acoustic and optic stimulation. Progress has been made towards the discovery of mechanisms subserving the conscious experience of interacting with mechanical objects. This progress is due in part to the availability of new instruments that can tightly control mechanical stimulation of both the ascending, i.e. sensory, and descending, i.e. motor, pathways. The program describes the design of new mechanical stimulation delivery equipment capable of fine segregation of haptic cues at different length scales and different time scales so that controlled stimuli may be delivered with the ease and accuracy which is today possible when studying vision or audition. The purpose of this equipment is to disentangle and recombine the individual cues used by the brain to recover the attributes of an object, leading to the identification of the computations that must be performed to achieve a perceptual outcome. In vision and audition, much is known of the nature of the peripheral and central computations, but in touch, for lack of proper equipment, little is known. From this knowledge, I aim at developing a theory of haptic perception which rests on the observation that these computations are distributed in the physics of mechanical contact, in the biomechanics of the hand, including the skin, the musculoskeletal organization, innervation, and in central neural processes. This research program is rich in applications ranging from improved diagnosis of pathologies, to rehabilitation devices, to haptic interfaces now part of consumer products and virtual reality systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design, synthesis and investigation of substituted oligonucleotides for the regulation of gene expression', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content Many human diseases arise from the dysfunction of genes. Oligonucleotides, which can form complexes with RNA or DNA by complementary base pairing, represent a new class of potential therapeutic agents for such diseases, acting directly on the nucleic acids. However, problems as the low stability of oligonucleotides in biological media, the poor penetration of oligonucleotides into cells and the reversibility of complex formation disturb the practical applications of oligonucleotides. Chemical modification of oligonucleotides, which will be the main objective of this project, could, at least partially, contribute to the resolution of these problems.The objectives of the research work will be: a)The attachment of a minor-groove-binding ligand to an oligonucleotide-intercalator conjugate (structure A), a novel and improved strategy for increasing the stability of oligonucleotide-DNA complexes.Oligonucleotide - L - intercalator - minor groove ligand (major-groove ligand)b)The employment of particular peptides as minor-groove ligands, which could exhibit several additional beneficial functions, such as a more effective internalization of the oligonucleotide or an extended range of recognition sequences. c)Synthesis of oligonucleotide-intercalator conjugates and testing for their ability to recruit topoisomerases (and, | possibly, other DNA-cleaving enzymes) for site-directed DNA damage.d)Elaboration of a reliable and versatile scheme for the modification of non-protected oligonucleotides which could be applied to a large variety of different ligands.e)The synthesized products will be tested in the appropriate system for their anti-sense or anti-gene effects. Links with industry / industrial relevance (22): Prof Claude Helene, the supervisor is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'EUCANCan: a federated network of aligned and interoperable infrastructures for the homogeneous analysis, management and sharing of genomic oncology data for Personalized Medicine.'.

assistant: **Objectives**

We propose to create the EUropean-CANadian Cancer network (EUCANCan), a federated infrastructure whose mission is to enable Personalized Medicine in Oncology by promoting the generation and sharing of harmonized genomic and phenotypic data. EUCANCan builds on work performed by members of the consortium and related projects to align and interconnect existing European and Canadian infrastructures for the analysis and management of genomic oncology data. The EUCANCan network will be composed of reference nodes in Amsterdam, Barcelona, Berlin, Heidelberg, Paris and Toronto which have established strong research and clinical programs in the field of genomic oncology.  These reference nodes will work together in an interoperable fashion to provide the genomic oncology community with a uniform computing environment for the processing, harmonization and secure sharing of cancer genome and phenome data in the context of clinical research, enabling the discovery of clinically-relevant patterns of variation in the cancer genome such as biomarkers predictive of therapeutic response. The infrastructure will also provide a proving ground for federated genome analysis systems that may one day be integrated into national and regional healthcare systems.EUCANCan’s objectives are: (1) harmonise protocols for the identification and interpretation of germline and somatic variation profiles within cancer genomes; (2) generate strategies for the flow, management, storage and distribution of data within and across EUCANCan nodes; (3) define community standards for data elements, types and formats; (4) develop an open and accessible data portals for the searching and download of EUCANCan data; and (5) define an appropriate ethical and legal frame to ensure the secure sharing of protected indiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accelerated market launch of MedEye, a plug-and-play medication safety solution' (MedEye).

assistant: **Innovation**

Medication errors occur daily and form a major burden to society. Medication errors often lead to adverse drug reactions, lengthened hospital stays, increased healthcare costs, and in the most severe cases, increased mortality. Medication errors pose a significant risk to the European population. It is estimated that 4,7 million Europeans are harmed by a medication error every year, which amounts to preventable healthcare costs in excess of €11 billion a year. Strikingly, around 50% of medication errors can be stopped at the patient’s bedside. MedEye is an innovative medication verification suite that scans, detects and verifies medication at the bedside. MedEye stops medication errors from taking place by verifying medication before it is administered to patients. MedEye has already been tested and validated in three Dutch hospitals with excellent results. In this project, activities will be performed to push MedEye onto the European market and facilitate its deployment on a large scale. MedEye will be integrated with IT systems that serve a major part of European medical centers. Developments will also be performed to enable the sale, deployment and support of MedEye through distributors. Two launching pilots will be performed to establish transnational proof of performance and cost-effectiveness, which will be instrumental in penetrating the European markets. Given the diversity of the European healthcare landscape, a thorough market research will be performed to gear the commercialization strategy towards individual countries. Together, the activities in this project will provide access to the main EU market and facilitate a wide deployment of MedEye throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enhanced Modeling and Optimization of Batteries Incorporating Lithium-ion Elements' (E-MOBILE) under Seventh Framework.

assistant: **Objectives**

Developing rechargeable batteries with larger storage capacity, higher output power, faster charge/discharge time, and longer calendar lifetime could significantly impact the economical and environmental future of the European Union. New generations of lithium-ion batteries (LIBs) based on nanostructured electrodes are perfect candidates to supply all-electrical vehicles and favor the usage of renewable energies instead of fossil fuels. Hence, the global LIB revenue is expected to expand from $11 billion in 2011 up to $50 billion in 2020. The goal of this project is therefore to provide an advanced simulation and optimization platform to design LIBs with improved performance and increase the competitiveness of Europe in this domain. The proposed computer aided design (CAD) tool must satisfy three key requirements in order to reach this ambitious objective: (i) computational efficiency, (ii) results accuracy, and (iii) automated predictability. Massively parallel computing has been identified as the enabling technology to handle the first requirement. The second one will be addressed by implementing a state-of-the-art device operation model relying on a multi-scale resolution of the battery electrodes, a detailed description of the electron and ion motions, a material parametrization derived from ab-initio quantum transport techniques, and a validation of the approach through comparisons with experimental measurements. Finally, to meet the last requirement, the operation model will be coupled to a genetic algorithm optimizer capable of automatically predicting the LIB configuration that best matches pre-defined performance targets. The resulting CAD tool will be released as an open source package so that the entire battery community can benefit from it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Direct detection of cancer-causing mutations in tumour specimens' (INSITUMUT).

assistant: **Concept**

Cancers develop because they acquire changes (mutations) in a specific set of genes that promote their growth. Different mutations are associated with cancer aggressiveness, patient prognosis and/or the response to treatment. Although these mutations can usually be detected by extracting DNA from tumour specimens, this provides incomplete information because it is common for mutations not to occur in every cell that makes up the cancer. In a number of research and clinical settings, it is of great use to learn which regions or cells within a cancer carry a particular mutation. To do this, we need to detect mutations in space by examining sections of tissue. There are several potential benefits, including sensitive detection of cancer cells that have been left behind after operation or that will cause relapse after treatment. Here, we shall develop a method to detect mutations in situ in cancer specimens. The INSITUMUT technique uses molecular probes that are specific to mutations in cancer genes and bind to RNA expressed from those genes. We have piloted the method successfully in collaboration with Advanced Cellular Diagnostics Inc., sensitively identifying cancer cells that have acquired specific mutations in the oncogene KRAS and specifically distinguishing them from cells and cancers with normal KRAS. Before making the method available, our workplan in this proposal involves determining probe sensitivity and specificity more accurately, expanding the range of cancer-causing mutations that are detected, developing methods for simultaneous detection of multiple mutations, extending the technique as far as possible to detection of mutations in DNA, and automating the mutation detection process. Subject to technical feasibility and commercial assessments, we shall disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart modular passive cool boxes for sustainable logistics' (SmartCOOLBOX), addressing dissemination and exploitation.

assistant: **Impact**

SmartCOOLBOX is presented as a Logistic service for high-reliability temperature-controlled products, based on:- SmartCOOLBOX itself, an intelligent, connected, reusable and modular ISOTHERMAL CONTAINER…- … that is OFFERED AS A SERVICE, which simplifies the managing of the transport processSmartCOOLBOX is an integrated combination of several innovations and technologies which feature:- Use of light and degradable materials, offering longer life isothermal conditions range at the same time (warrantiedfor 7 days, following the defined storage and handling conditions)- Modularity and adaptation to actual goods measures- Smart sensors for tracking the conditions of the transport- Smart alerts system to track, and prevent or detect incidents, enabling rescue actions- Reusability of boxes and materials- Service covers the full supply chain, including reverse logisticsWith SmartCOOLBOX, hospitals, labs and generic logistics operators may handle materials without relevant precautions,increasing safety while decreasing costs. Pharma and biotech industries will reduce losses due to temperature excursionsand, at the same time, will open new markets such as difficult geographic areas, as well as disaster areas or in conflictregions. From environmental perspective, savings will come by modular reusable boxes and less wasted products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and clinical validation of novel smart device to provide real-time ablation + tissue analysis through advanced 4D imaging to enable >90% success rate in Atrial Fibrillation treatment' (VERAFEYE) targeting Horizon 2020.

assistant: **Abstract**

OneProjects is a new medical device company based in Dublin and Munich developing the new wave of disruptive cardiac imaginginnovations that will provide a sea change in the treatment of atrial fibrillation (AFib) through ablation. With the clinical need at thecore of our mission and world-class expertise in medical imaging and product commercialisation, OneProjects is developingVERAFEYE, a novel smart catheter system that provides real-time 4D ablation/tissue analysis and navigation enabled throughadvanced imaging and analytics.VERAFEYE is a breakthrough connected technology which can generate unprecedented 4D data during the ablation procedure, thusproviding the physician with real-time analysis of the surgery. VERAFEYE will for the first time allow clinicians to correct and enhancethe treatment in the 1st procedure, ensuring the patient is AFib free, and hence remove the need for multiple surgeries. VERAFEYEwill shift treatment to the era of evidence- and data-based success rather than purely relying on the experience of theelectrophysiologist as is currently the case.


**Keywords:** Atrial Fibrillation, Catheter Ablation, Improved Efficacy, 4D Tissue and Ablation Analysis,  Electrophysiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project '321NOW: The Now Booking Channel' (321NOW) under Horizon 2020.

assistant: **Objectives**

The travel sector has been changing considerable since the low cost carriers broke in the market. Traditional airlines have tried to compete but there is still a long way to run. Airlines have an average of 16% free seats when taking off, with low costs carriers being the ones that travel with less empty seats thanks to their costs structure and princes offered in such a competitive marketplace. 321NOW has created the first Virtual Low cost, using the spare seats that were not going to be sold through traditional sales channels, and selling them 8 hours before the plane takes off. We sell the tickets covering the variable costs of the passenger (airport taxes + food –if included-), plus a benefit for the airline and a management FEE for 321NOW. In addition we will sell separately services, such as seats selection, luggage, Wifi, helping the airlines to increase their profit and to better compete with the Low Cost companies.