RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PRotein cOatings to prevent Bacterial Infections' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Biomaterials are revolutionising many aspects of preventive and therapeutic healthcare. They are already playing an important role in the development of new medical devices, prostheses, tissue repair and replacement technologies.This proposal addresses two of the most critical issues in biomaterials research: lack of knowledge of the fundamentals processes underlying interfacial interactions and bacterial infection.We will focus our research on materials used for ophthalmological implants and in particular on the ones used in the manufacturing of intra-ocular lenses for cataract surgery. We will study the interaction of Staphilococcus epidermidis with biomaterial surfaces with nanoscience techniques. Staphilococcus epidermidis ranks first among the causative agents of nosocomial infections. In particular, S. epidermidis represents the most common source of infections on indwelling medical devices. Based on the knowledge accumulated in recent years about the characteristics that make a successful biocompatible interface we propose to research on the properties of amphipatic fungal proteins Hydrophobins as a plausible candidate to modulate the biomaterial interface. In particular, we will investigate class I hydrophobin extracted from the basidiomycete fungus Pleurotus ostreatus, whose properties are only partially investigated. Several studies have shown that class I hydrophobins do not seem to be toxic or cytotoxic or immunogenic, thus they are susceptible to be used in various medical and technical applications.We propose to coat model surfaces with thin layers of native hydrophobin. The adhesion properties of the layer to the substrate as well as the wetting properties of the biofilm surfaces, will be fully investigated. Subsequently interaction of bacteria with  hydr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Threat and Reward learning in Adverse Childhood Experiences'.

assistant: **Concept**

Childhood adversity is a major transdiagnostic risk factor for psychiatric disorders and affects around 50% of children worldwide. Despite its prevalence and impact, the psychological and neurobiological pathways linking childhood adversity to mental health outcomes remain poorly understood. Building on recent advances, this project will investigate fundamental learning processes, i.e., threat and reward learning, as key mechanisms underlying this association. The focus is on adolescence, a critical developmental window for the emergence of psychiatric symptoms.In a first work package, I will crucially add to the conceptual clarity within the field of childhood adversity by systematically reviewing existing theories and their evidence. Additionally, across two interrelated work packages, I will integrate experimental and neurobiological approaches in a developmental population to identify pathways by which childhood adversity increases risk for psychopathology.Building on my expertise in threat learning in childhood adversity, this fellowship will substantially broaden my expertise in multimodal data collection, advanced analytical techniques, and the management of large-scale studies with vulnerable populations. I will gain hands-on experience in open science practices under the guidance of a supervisor strongly committed to transparency and reproducibility, strengthening my scientific rigor and visibility. In addition, teaching activities and an expanded international research network will foster key transferable skills, enhance collaborative opportunities, and support future grant acquisition. Ultimately, this fellowship will provide the crucial foundation for my long-term goal: establishing an independent research lab dedicated to understanding and mitigating the im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Membrane Dynamics in Endocytosis' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Endocytosis is the process whereby eukaryotic cells internalise components such as nutrients from the surface into the cell interior. However, in addition, endocytosis serves multiple key cellular functions such as response to growth factors and hormones, immune response and antigen presentation, neural transmission. Several forms of human diseases are associated with defects in cargo selection and transport. For example, inherited defects in receptors can cause hypercholesterolemia and heart diseases, and mutations in the genes encoding a number of the hydrolytic enzymes of the endocytic pathway cause severe lysosomal storage diseases. Furthermore, the endocytic pathway is an entry route for viruses, bacteria and other parasites that penetrate the cell interior upon phagocytosis and begin their cycle of infection. In the past few years, several important insights have been made into the molecular mechanisms underlying these processes. Nevertheless, our knowledge is fragmentary and we are far from having a precise understanding of how transport in the endocytic pathway is regulated. The aim of this conference is to present the latest advances in the field and discuss novel concepts and future research directions that can lead to a molecular understanding of the function of endocytosis.The objectives of this conference are manifold: 1) To understand how proteins and lipids are correctly sorted within a specific membrane system, 2) to determine which vesicles transport which cargo and which machinery is responsible for vesicle formation, 3) how are assembled and pinch off at the cell surface, 4) what mechanisms are responsible for assembling all these machineries into larger protein- lipid complexes and finally form an entire endocytic organelle (or endosome), 5) how many
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Produktionstechnologie zur metall-sustitution in der kommunalen und industriellen gas-und wasserversorgung' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

For the substitution of metal in the field of gas and water utility the use of carbon fibre prepreg cut up of the aircraft building industrv will be investigated. Improved behaviour, high weight and also cost reductions up to 15% are anticipated but not verified. The metal elements in use are heavy in handling, expensive in production and suspect to corrosion The research is aiming for a general methodology for the preparation of a compound, the moulding and production of functional systems. The task of preparing a reliable material structure is made difficult since the prepreg cut up material is not reproducible in its origin. Furthermore the specification of the metal elements are not specifically declared, but grown by experience. Thus an assessment,using the profile of the known metal elements shall enable to determine the boundary conditions as well as the definition of the specification of the intended plastic parts in terms of environmental and load attack. The exploratory phase aims at clarifying of basic constraints for a subsequent CRAFT project and shall also help to find appropriate partners for the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A new high-performance and environmentally clean engine for heat pumps, using thermo-acoustics technology'.

assistant: **Innovation**

Heat pumps are the best sustainable solution for heating and cooling, but they have performance limitations and are very expensive, preventing them from having the desirable market traction.Blue Heart Energy (BHE) has developed a disruptive patented technology, based on thermoacoustics, that significantly improves the performance of heat pumps. With our solution, heat pumps turn into flexible, silent and affordable devices. We do not use any HFC-gases and our system is adequate for both new and existing houses.Blue Heart leverages 15+ years of R&D from TNO, a leading Dutch research organization, and has been designed in close collaboration with leading OEMs to seamlessly replace the engine of every heat pump. Our scalable B2B business model will leverage the distribution channels of heat pump manufacturers, ensuring a fast adoption by end customers and accelerating the energy transition.BHE has a multidisciplinary team of 15 people and is led by a highly experienced management team.


**Keywords:** Environmental and Green Technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Up-scaling, demonstration and first market application of Loritus’ patented hydrothermal carbonisation as an eco-efficient and cost-effective organic waste processing technology' (HTC4WASTE) targeting Horizon 2020.

assistant: **Abstract**

The objective of HTC4WASTE is to demonstrate – at full scale and in a real market application – the technical and commercial excellence of Loritus’ unique, patented Hydrothermal Carbonisation (HTC) technology as a flexible organic waste recovery technology, suitable for converting organic waste streams into carbon neutral biocoal, carbon sequestering biochar, fertility products, water, and local thermal energy.During the project, Loritus will build a full-scale HTC installation to demonstrate its economic and technological performance across a range of commonly occurring waste streams sharing characteristics that make them costly to treat with established technologies. The demonstration will target at least three market applications (sewage sludge, food waste and animal by-products, and spent mushroom compost) on a commercial scale (10.000 tonnes/year).Loritus will then operate the full-scale HTC system on a specific organic waste stream, spent mushroom compost, at a mushroom farm in Ireland to finalise the business case for HTC in a real life, industrial scale application. Such a success will induce a multiplication effect across the associated multi-national farming cooperative, and provide evidence that clients in other market segments can gain the same HTC cost and environmental advantages. Loritus will prioritise and pursue these segments aggressively.Ultimately, Loritus will jumpstart its operational capabilities, and build a dominant reputation in the HTC field with this project as the catalyst. Loritus will crystallise its targeted markets and demonstrate where HTC can outperform established technologies with a no subsidies business case. Potential clients will be invited to see the full-scale plant in operation, and the project data used to identify economic cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Realizing ambulatory shock-free termination of atrial fibrillation' to be submitted under Horizon Europe.

assistant: **Abstract**

Atrial fibrillation (AF) is the most common type of heart rhythm disturbance, progressive in nature and associated with high morbidity and mortality. Thus, an effective and broadly applicable treatment to quickly restore normal rhythm at any time and place is highly desired. However, such therapy is lacking. In contrast to drugs and ablation, electrical cardioversion of AF is effective in broad populations of AF patients, but can only performed within hospitals because of the required patient sedation due to the use of high-voltage shocks. This undesired delay in treatment, huge hospital workload, and impact on patient mobility, further signifies the need for the development of new treatment strategies.To overcome these challenges and meet this need for new therapeutics, my group developed the concept of optoelectronic cardiac rhythm control. This approach is based on the paradigm that arrhythmia termination for restoration of normal rhythm can be achieved by appropriately timed generation of bioelectrical currents by the arrhythmic heart itself. To enable such shock-free and therefore pain-free AF termination, cardiac tissue will be optogenetically modified to express light-sensitive proteins. A small implantable optical defibrillator will trigger the release of light pulses by a multi-electrode LED array upon automated AF detection. Our recent results in rodents show that this indeed results in pain-free and immediate AF termination, thus overcoming the drawbacks of electrical cardioversion.To realize valorisation towards clinical exploration, Opto-AF-Therapy will focus on the optimization of the expression cassette for optogenetic modification of atrial tissue and conduct first proof-of-principle large animal studies. Complementary to these activities, my team will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Intuitive, rapid and efficient in-situ measurement of complex transparent 3D objects with a focus on cultural heritage artifacts'.

assistant: **Objectives**

Transparent 3D will create an easy-to-use, non-contact measurement hardware and software package to dramatically reduce the cost of measuring complex transparent objects by greatly accelerating and streamlining the measurement procedure. The technique used will be based on the principle of non-contact high-incidence structured light. The hardware and software package will employ a combination of artificial intelligence, augmented reality, structured light, data fusion and human operator real-time feedback in order to optimize and simplify the full 3D reconstruction process of complex transparent objects. The feature of real-time feedback and guidance to human operators in particular would allow a non-expert to acquire a complete measurement of a transparent object in the minimum amount of time and with the minimum amount of raw data, thus making the process practical, cheaper, less demanding in terms of data storage and more accessible to curators and novice users. This unprecedented and markable improvement will make the process fast and cheap enough to enable the 3D documentation of thousands of sensitive transparent 3D cultural heritage objects in situ.The impact of the platform created and its competitive advantages over existing techniques will be demonstrated in the field with a multi-national cultural heritage case study conducted at three cultural heritage institutions in Greece, Italy and France.This proposal was also submitted in last year's Standard EF MSCA funding round (Proposal No. 841298) with the same acronym 'Transparent3D' and received the EU Commission's Seal of Excellence on 19/03/2019. Since then reviewer comments have been addressed and an extra case-study partner has been added to the list of supporting institutions (The Androidus Project Tank).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low power high image quality display using colour sequential display technology' in the context of a Seventh Framework call.

assistant: **Objectives**

There is growing awareness that our hunger for energy has a large impact on the environment. A significant amount of energy is consumed by electronic devices that we use. In Europe we consume 210,000 MWh a day watching TV. In China, power consumption will increase dramatically in the future. Liquid Cristal Display (LCD) is the major display technology for the coming 10 years. Although LCDs offer many benefits, they provide a relatively poor system solution in terms of power-efficiency. Unfortunately, the LC panel efficiency is limited to 5-7%. A good solution to reduce the power consumption is to remove the colour filters and generate the colour temporally. First prototypes have shown this successfully, but they suffer from severe colour breakup artefacts. The focus of the research carried out in this proposal is to find solutions that suppress colour breakup without the need for unrealistically high refresh rates. The hosting party published some first results using a 120 Hz colour sequential system with two colour filters and two colour fields. Although the colour break-up is reduced, it remains well visible for certain important classes of images. In the literature also other methods are described that could reduce the colour breakup, but they were unsuccessful to eliminate the colour breakup. IIF candidate,Y. Zhang, will develop new algorithms that drive the backlight and the panel in such a way that the colour breakup is reduced to an acceptable level. The hosting party also has excellent facilities for perception research and video processing development and testing, and has the hardware or the facilities to build the hardware required to study and test the colour breakup phenomenon. This project offers a unique opportunity to foster and further strengthen the exi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Acoustic radiation of small turbomachines (AROMA)' (AROMA).

assistant: **Innovation**

Predicting the noise produced by turbo machines requires three essential modelling components:(1) an accurate description of the flow through the turbo machine (WP1 ) ;(2) a model predicting the amplitude of the acoustic source from the results of the CFD calculation (WP2) ;(3) a prediction of the propagation of the source in a lined duct taking into account the flow field in the duct (WP3) .The different components must then be seamlessly integrated and connected to an optimisation tool (WP4).Finally each component of the loop and the integrated system must be validated against experimental results (WP5) .In order to be successful the project must be managed and its results disseminated and exploited (WP6).The proposal is a result of the SCRATCH initiative and give therefore a leading role to SME. The focus is also on the development of a product methodology that can be exploited by the SMEs at the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biotechnology for Africa's sustainable water supply' under Seventh Framework.

assistant: **Concept**

More than water scarcity, diseases and civil wars, Africa is also the least wealthy continent, in terms of economic and financial resources. These combined and tightly linked problems have led to a restricted range of choices, affordable for African countries, to deal particularly with the water issue, as a major topic. Polluted water treatment before use has been their almost unique solution to deal with a growing water scarcity. The treatment of water and elimination of pollutants, mainly pathogenic organisms, xenobiotics and heavy metals, although itself presents significant challenges, is crucial for human health and environmental considerations. However, most regions in developing countries cannot afford the costs of advanced and specialized systems.Numerous water cleaning methods are based in natural, plants or micro-organisms, biochemical processes. Biotechnology is a useful tool that is delivering improved products and process for environmental sustainability, and promises a range of benefits to manage the industrial WW economically and effectively around the world. Some biotechnological techniques are quite sophisticated but others are simple, cost effective and adapted to local conditions and resources of developing countries.These natural biological treatment systems include lagooning, land treatment, phytodepuration, or constructed wetlands systems. They can be applied as secondary or tertiary purification treatment, allowing the removal of pathogenic microorganisms and the degradation of the organic pollutants, so that waste water can be recycled for irrigation and domestic use and hence reduce the pressure on the hydric resources. Other biotechnological techniques to be taken into account within this proposal are biofiltration, membrane bioreactors and alg