RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced theories for functional oxides: new routes to handle the devices of the future' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Transition metal oxides are the building blocks of future microelectronics, due to outstanding properties such as, e.g. colossal magnetoresistivity and electroresistivity. Envisioned applications are countless, from spintronic devices to multiferroics, to non-volatile magnetic memories.  Despite the huge amount of work already accomplished, a deep and complete understanding of these systems is still lacking. This is due on the one hand to the complexity inherent to the physics of strong-correlated electrons, which includes a plethora of fascinating but overtly complex phenomena (e.g. charge and orbital ordering, polaronic formation, spin-charge separation, non-Fermi liquid behavior, to name just few). On the other hand, there is an unquestionable lack of coordinated effort devoted to share, integrate, and develop the most advanced and powerful computational techniques nowadays available. With the present project we aim to close this gap by gathering in a synergic collaboration some of the most experienced groups in the subject, equipped with the most advanced methodologies for the theoretical study of strong-correlated phenomena in transition metal oxides. Specifically, the European units assemble a vast competence on methodologies that are at the developmental forefront of First-Principles methodologies, whereas the Indian partners are worldwide recognized experts on both First-Principles and model many-body (e.g. Hubbard Hamiltonian (HH)) techniques. In the project we plan to develop an unprecedented fusion of these two different but complementary viewpoints, applied to the study of the most fascinating and technologically promising class of systems candidates to be employed in the devices of the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Prioritization, incentives and Resource use for sUstainable DENTistry' (PRUDENT), addressing dissemination and exploitation.

assistant: **Impact**

Oral diseases and conditions are the 3rd most expensive diseases to treat in the EU. They affect about half of the EU population. As highlighted in the 2021 WHO Oral Health Resolution, there are major challenges in the financing of oral health care: in deviation from the UN and WHO goal of Universal Health Coverage, many EU citizens do not have access to essential oral health care without financial hardship. This causes detrimental impacts for the individual citizen, while increasing costs and wasting resources on the macro level. Research-policy gaps and research-practice gaps keep triggering inertia and inaction instead of addressing the persistent, albeit largely preventable, burden of oral diseases. To this end, the PRUDENT (Prioritization, incentives and Resource use for sUstainable DENTistry) project aims to develop and implement an innovative and context-adaptive framework for optimized financing of oral care. PRUDENT brings together top investigators from prestigious universities, public authorities and policymakers, civil society and patient organizations, health insurers, and health professionals, to achieve a step change in collective problem solving. Given the comprehensiveness of the topic, PRUDENT uses a targeted approach that is entirely focused on four major root-causes underlying the current limitations of oral care financing. Using a mixed-methods research approach, PRUDENT will: (i) co-develop oral health system performance indicators and implement them in EU-wide monitoring framework; (ii) conduct real-world and lab experiments to identify improved oral care financing mechanisms; (iii) leverage regulatory learning, needs-adaptive resource planning and deliberative priority setting to enhance the improvement of oral care financing. The knowledge gaine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Doctoral Training in developmental cognitive Neuroscience within a European Context'.

assistant: **Concept**

We will provide a structured training programme based on the completion of individual research projects that gravitate around a common research agenda.That agenda is to understand the neural basis of cognitive functions, and their typical and atypical development in the infant, child and adult brains through the combination of neuroimaging, computational modelling and behavioural testing.We aim to understand typical and atypical developmental paths in infancy and childhood relative to cognitive functions in the adult brain, and also look for parallels between mechanisms of early cognitive development and the mechanisms underlying changes in brain function as a result of learning and plasticity later in life.Early stage researchers will be hosted at the Centre for Brain and Cognitive Development (CBCD) Birkbeck College, University of London. The CBCD provides a uniquely European context for research both through the transeuropean origins of its members and its multiple research links with institutions across Europe (and especially new member states).Early stage researchers will be expected to enrol in a 3-year doctoral training programme that seamlessly integrates 3 levels of support and training that includes short-term secondments to institutions across Europe, generic research skills training, and pastoral support.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Atomic-Scale Tailored Materials for Electrochemical Methane Activation and Production of Valuable Chemicals' under Horizon Europe.

assistant: **Concept**

Electrochemical methane activation and direct conversion to methanol is highly attractive –  a dream reaction that would convert a greenhouse gas into a valuable liquid fuel in a dream device, on-site, and powered by renewable electricity. However, sustainable C-H activation and direct methane to methanol conversion at ambient conditions remain as great fundamental challenges.My aim with ATOMISTIC is: (i) to develop new methods for electrochemical methane activation and partial oxidation, (ii) to control the structure of the electrochemical interface and the catalytically active site, in order to tune selectivity for the synthesis of valuable fuels and chemicals (such as methanol) from methane, and dimethyl carbonate from methanol. I will use 3 main strategies:-To establish the ideal structures and electrolytes, using well-defined tailored materials that enable methane activation by its direct adsorption on the electrode material.-To realise advanced materials that enable the indirect electrochemical activation of methane through the generation of solution phase radicals.-To tailor the active site at the atomic level for selective methane to methanol and methanol to dimethyl carbonate oxidation reactions on functional materials.I will elucidate the design principles and unveil the structure-reactivity-selectivity relations and the molecular mechanisms of these reactions as well as the atomic-scale structure of the catalyst materials. I will achieve these ambitious goals by leveraging my work combining the insight from model studies with experiments under realistic conditions to discover new materials. I will combine electrochemical methods, electrochemical scanning probe microscopy, in situ optical spectroscopy, online mass spectrometry and operando synchrotron-based x-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Improving Biomedical Research and Innovation in the Canary Islands'.

assistant: **Objectives**

To unlock and develop the research and innovation potential of the Centre for Biomedical Research of the Canary Islands (CIBICAN), a coherent series of activities have been designed through the development of this project (IMBRAIN). From a recent SWOT analysis, several  impediments have been identified that must be overcome to maximize our research capacities. They include the isolation from decision−making centers and resources, the excessive cost and effort required to coordinate and collaborate in projects and to disseminate research achievements both into the science community and the society. In addition, despite the quality of the research teams and their focus on priority areas, the problems of recruiting experienced new researchers, technical staff and innovation managers remain a serious handicap that we are strongly committed to overcome. The main strategic objective of this project is to increase the quality of research at CIBICAN, and to build its innovation capacity to become a leading centre in Biomedicine and the Health Sciences. It will have a significant impact in promoting regional economic and social development, and in spreading of health knowledge into the outermost EU regions and the near African countries. This will be achieved through the following measures:  1) Exchange of know-how and experience with EU research partnering organizations; 2) Recruitment of experienced researchers, technical staff and innovation manager; 3) Upgrading of research equipment, based on existing infrastructure and core facilities; 4) Elaboration of a strategic IP development plan for IP management and protection and innovation capability building; 5) Dissemination of knowledge on health and increase the visibility of CIBICAN activities at regional, national and Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Risk planning process', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content This project concerns product development risk. The risks in product development, particularly in the area of product innovation, are high, and special methods will be developed to identify, evaluate and control these risks. There are many different schemes available for product development and product introductions, but none specifically address the risk issues in a coherent and integrated fashion. Risk is a broad area of research in terms of the subject area (physical, environmental, financial, etc) and in terms of the different technologies which can be brought to bear for example those from reliability. It also is studied at different levels in companies from the strategic level (where holistic models are sought) to the more detailed technical level. The present project will fuse together the human end of risk, in terms of risk identification, and the technical end of risk, based on advanced methods from statistical decision theory. This combined strategy will be applied to the product development risk itself. Following initial stages of process capture and risk identification and evaluation a decision is made on whether to proceed with a product, and then the Risk Planning Process will use a sophisticated risk engine" based on Bayesian belief networks to manage the risk aspect of the product development itself. These methods allow, in particular, the merging of subjective beliefs with hard data. These stages will be integrated into a software package combining the soft and hard risk methodologies with the various stages of product development. The project should have wide applicability across a number of industries, which are well represented by the different sectorial responsibilities of the industrial partners. The academic partners will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Massive Reverse Genomics to Decipher Gene Regulatory Grammar' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

MRG-GRammar aims to devise an entirely new strategy for deciphering the regulatory rules of gene regulation. We will leverage Synthetic Biology with cutting-edge DNA synthesis technologies and high-throughput analysis to generate new types of biological datasets that systematically explore all possible regulatory landscapes rather than just the naturally occurring regulatory sequences. The extensive and unbiased nature of these unique datasets will allow us to build new models explaining different aspects of regulatory activity, which will be tested in second-generation libraries, designed based on model predictions. Consequently, through such an iterative process, we expect to make a significant breakthrough in deciphering, and evolving, the regulatory code. Our strategy synergizes four orthogonal objectives that will form a new knowledge base from which the regulatory algorithm can be derived. We will employ our strategy on diverse model organisms from the tree of life, from single cell to whole organism: bacteria, yeast, mouse ex-vivo cells, human cell-lines and finally, whole D. melanogaster and mouse embryos. We expect this multidisciplinary synthetic biology approach to generate a major technological advance, which will provide the community with algorithms that will not only decipher extant natural regulatory code, but also interpret variations leading to a profoundly deeper understanding of the origins of many diseases. We expect our models to also serve as a reference in designing and implementing accurate and more controllable synthetic biology devices, with applications in fuel production, healthcare and other industrial fields. Thus, our ultimate goal is to substantially accelerate the advance of technologies and knowledge related to generating systematic an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Role of the map kinase cascades in the growth and differentiation of endothelial cells'.

assistant: **Concept**

Research objectives and content The initial phase of tumor development is limited by the absence of vascularization. Anoxic and nutritional stress elicit the production by the tumoral cells of angiogenic factors, such as bFGF and VEGF, that stimulate the proliferation of the endothelial cells from the neighbouring capillaries. Endothelial cells, normally quiescent, carry all the information to form whole capillary networks, but the intracellular signals implicated in the proliferation and differentiation of endothelial cells are not well understood. In this context, our general objective will be identify the intracellular signals which promote either the proliferation or growth arrest of endothelial cells, and the signals implicated in their differentiation. We will focus our attention on the involvement of the MAP kinase cascades in these processes. Endothelial cells undergo growth arrest in response to cellular contact. In epithelial cells such inhibition is due to an upregulation of the p27 cyclin inhibitor. Our current research has revealed that in several different endothelial cell models in culture, activation of MAP kinase in response to mitogens is potently attenuated in confluent cells in comparison with sparse cells. Hence. in the first part of the project our objective will be to study at what level of the MAP kinase cascade the inhibition occurs. The second objective will to asses the importance of an inhibition of the MAP kinase cascade in confluent endothelial cells to the contact mediated growth arrest process. Is an inhibition of MAP kinase directly responsable of the growth arrest in contact inhibited cells? Does this inhibition of MAP kinase lead to the upregulation of the cyclin inhibitor p27 protein levels observed in confluent cells in comparison wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'REdox fLow batteriEs powered by eCo-maTeRiAls' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Novel materials and developments for Energy Storage applications are the most active and successful research topics in Europe. Redox flow batteries (RFBs) are the only option for the implementation of the intermittent renewable energy as they promise long lifespam in a design with independently energy/powers output. However, the bottleneck to realize this energy scenario is the lack of stable and inexpensive components, which substantially breaks the energy storage/power limits. Thus, we propose to investigate a family of earth-abundant and recyclable materials, based on transition metal oxyanions clusters (polyoxometalates, POMs). This appealing alternative provides fast multi-electron transfer processes, offering excess of capacity in a reversible and stable fashion. Our research program involves the creation of electron-rich POMs structures based on W and Mo atoms in a low-cost synthesis process, suitable for large production. We will fabricate a large family of POMs, modulating their redox properties through the composition and electron delocalization properties. These features will maximize the energy density values through the implementation of POMs in the RFB, which will be tested into configurations: (1) POMs as redox active specie, and (2) POMs as charge carrier to solid active material confined in the tank. This intriguing and disruptive approach allows 10-fold energy density values in comparison with conventional RFBs. Additionally, the implementation of POMs molecules as active centers into innovative freestanding electrodes, with sophisticated architectures will surpasses the power values, though the suppression of side reaction as well as enhanced electrochemical activity. The reaction mechanism for the multi-electron transfer process at these interfaces w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA repair factories how cells do biochemistry' in the context of a Seventh Framework call.

assistant: **Objectives**

The integrity of a cell's genome is constantly challenged by DNA lesions such as base modifications and DNA strand breaks. A single double-strand break is lethal if unrepaired and may lead to loss-of-heterozygosity, mutations, deletions, genomic rearrangements and chromosome loss if repaired improperly. Such genetic alterations are the main cause of cancer and other genetic diseases. Homologous recombination is an error-free pathway for repairing DNA lesions such as single- and double-strand breaks, and for the restart of collapsed replication forks. This pathway is catalyzed by giga-Dalton protein complexes consisting of dozens of different proteins. These DNA repair factories are able to catalyze complex, multi-step biochemical processes, which have so far failed reconstitution in vitro. The aim of this project is to establish an understanding of how cells catalyze complex biochemical processes such as homologous recombination in vivo. To reach this goal, we will seek to define the complete set of RNA and protein components of DNA repair factories using a combination of genetic, cell biological and biochemical approaches in the yeast Saccharomyces cerevisiae. Further, we will characterize the molecular architecture of DNA repair factories using fluorescence resonance energy transfer (FRET) and by applying systematic hybrid loss-of-heterozygosity (LOH) to physical interactions among DNA repair proteins. Key findings will be extended to metazoans using the chicken DT40 model system. My aim is to determine the fundamental molecular principles that govern protein factories in living cells. As such, our results are likely to be directly relevant to other protein factories such as DNA replication factories, PML bodies, nuclear pore complexes and transcription clusters.