RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'REPAiR - REsource Management in Peri-urban AReas: Going Beyond Urban Metabolism' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A shift towards a more circular economy is crucial to achieve more sustainable and inclusive growth. Our objective is to provide local and regional authorities with an innovative transdisciplinary open source geodesign decision support environment (GDSE) developed and implemented in living labs in six metropolitan areas. The GDSE allows creating integrated, place-based eco-innovative spatial development strategies aiming at a quantitative reduction of waste flows in the strategic interface of peri-urban areas. These strategies will promote the use of waste as a resource, thus support the on-going initiatives of the EC towards establishing a strong circular economy. The identification of such eco-innovative strategies will be based on the integration of life cycle thinking and geodesign to operationalise urban metabolism. Our approach differs from previous UM as we introduce a reversed material flow accounting to collect data accurate and detailed enough for the design of a variety of solutions to place-based challenges. The developed impact and decision models allow quantification and validation of alternative solution paths and therefore promote sustainable urban development built on near-field synergies between the built and natural environments. This will be achieved by quantifying and tracking essential resource flows, mapping and quantification of negative and positive effects of present and future resource flows, and the determination of a set of indicators to inform decision makers concerning the optimization of (re-)use of resources. The GDSE will be open source. With a budget of €5 million, REPAiR funds a consortium rich in experience in waste and resource management, spatial decision support, territorial governance, spatial planning and urban design, and has d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Deciphering the computations underlying visual processing: Repurposing of retinal cells and how they are decoded by the visual thalamus'.

assistant: **Innovation**

Visual processing begins in the retina, with ~30 types of retinal ganglion cells (RGCs), each encodes a specific visual modality, such as edges or motion. A major challenge for deciphering the visual code is mapping the connections between each RGC and its target neurons, such as in the lateral geniculate nucleus (LGN) and, via the LGN, the visual cortex. Recently, this challenge became even greater, as we and others revealed that the modality encoded by RGCs—traditionally considered a fixed hardwired property of each RGC type—can be altered. Direction selective RGCs reorient their directional tuning following visual adaptation, and other RGCs change their polarity preference (On/Off) as light level changes. These newly discovered dramatic changes in the core computations of RGCs depart from the known retinal adaptation which results in gain adjustments but no modality changes. We term them repurposing.The discovery of repurposing contrasts the widely-held notion that the retina provides a stable representation of the visual scene for downstream processing. This newly exposed level of complexity in the retinal code raises a critical question for our understanding of vision: How do retinal targets interpret the dynamic retinal code and how, despite such dynamics, a consistent representation of the visual scene emerges?We will use state-of-the-art electrophysiology and imaging techniques, and pioneer an approach for simultaneous retinal imaging and LGN recordings, to reveal how the mouse early visual system processes the changing visual information. We will elucidate the subtypes of repurposed RGCs, triggers for repurposing and their mechanisms. We will resolve, for the first time, the precise functional connectivity between subtypes of RGCs and LGN neurons, and determine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Complementary and alternative medicine - assessment in the cancer field' in the context of a Fifth Framework call.

assistant: **Objectives**

CAM recourse from cancer patient and health professional is reported to grow up. Misinformation can lead the patient to get wrong expectations regarding treatment options. Misinformation could lead lack of compliance and undermine treatment effectiveness. Organisations against cancer have launched initiatives for providing suitable evidence-based information for health professional and cancer patient. The results of these varied initiatives are redundancies of activity and sometimes outdated information. This project aims to integrate already existing and funded European initiatives. CAM-CANCER aims to provide the co-ordination and communication structure. CAM-CANCER will develop an electronic network.CAM-CANCER tasks are:1) Pooling and assessing the available scientific evidence2) Collecting and analysing information on CAM products and their promoters3) Produce and disseminate information for patients and health professionals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced functionality of textiles by biopolymer surface modification', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The objective is to obtain knowledge-based textile materials with new functionalities and environmental responsiveness for advanced applications (e.g. medical, safety and care). This new material will change a number of specific properties in response to variation of environment (PH and temperature).New functionalities will be implemented by appropriate surface modification (coating) of textile materials (cotton or/and polyester) with a thin layer of surface modifying system (SMS) based on biopolymer chitosan in its most adequate form (nano- or microparticles, emulsions, films and hydrogels). Chitosan can form environment-sensitive polymeric systems by various mechanisms of physical and chemical crosslinking with other polysaccharides or synthetic polymers.Currently known chitosan based SMS forms possess low mechanical strength and slow response times. Incorporation of SMS on textile fibre surface would give excellent strength and greatly reduced response times due to high active surface areas of the fibres. In response to an external stimuli, environment-sensitive SMS could drive the release of an active substance (drugs, fragrance, etc.), and hence give a new functionality to the textile material.The main challenges in achieving new textile material lay in finding the adequate form of effective surface modifying system (SMS) and increasing of surface adhesion of existing textile fibres in order to obtain durable coating. To improve the substrate's adhesive nature and enable subsequent coating with chitosan based SMS, the low temperature plasma (LTP) treatment will be used.The innovative textiles are of special interest for EU where the textile industry is intensively searching for new ways to enable the transition from resource-based towards knowledge-base d productio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Free-space optical transmission links with unprecedented receiver sensitivity', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Free-space optical communication links provide higher capacity and smaller beam divergence than their radio-frequency counterpart, and are increasingly being used for relatively short links often established for temporary purposes (e.g. outdoor sporting and concert events). They are also explored for extremely long reaches (e.g. between satellites, to the moon and beyond). In both cases, the sensitivity is fundamentally limited by the effect of diffraction, which results in the divergence of a free-space beam as it travels from the transmitter to the receiver.  As there are practical limits on the size of the aperture permitted at both the transmitter and receiver, the diffraction results in a signal loss that limits the capacity and reach of the link.   Our approach, which is to implement a unique noiseless optical amplifier in the receiver, is expected to result in a 40% transmission reach extension, or for a given reach target, reduce the aperture size of the optics (significant cost reduction) and increase the capacity. Our technique will help enable the transition from radio-frequency links to lightwave based links as it add significant performance benefits to the latter approach.   We wish to use our new knowledge and expertise from our recent ERC AdG project to demonstrate, verify, and explore the commercial prospects of FSO transmission using phase-sensitive amplifiers in the receiver to improve the sensitivity, thus maximizing the possible link power budget, beyond what is possible with today’s approaches.   We will work on market evaluation, technology verification, and commercialization strategy with the support from the Chalmers innovation office on our campus which has expertize on commercialization in the early stage. A goal of this project is to reach an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Programming the EPIcardium to CURE broken hearts' (EPICURE), addressing dissemination and exploitation.

assistant: **Impact**

Cardiac diseases are the leading cause of death worldwide, making human cardiac regeneration one of the most critical unmet clinical needs. The epicardium, the mesothelial envelope of the heart, is the source of several cardiac cells and provides signals that are essential for myocardial growth and vessel formation during development. Extensive animal research has indicated that the reactivation of these embryonic epicardial programs is the key to adult tissue repair in regenerative species such as the zebrafish, as well as in rodents up until a few days after birth, before the heart’s capacity for regeneration is lost. How the human epicardium develops and responds to injury is largely unknown. We recently established the first human pluripotent stem cell-based cardiac organoids showing the self-organization of epicardium and myocardium into a functionally patterned structure resembling the embryonic ventricular wall. These ‘epicardioids’ offer unique possibilities to study the dynamics of human epicardium development and function at a single-cell resolution. EPICURE aims at decoding and harnessing these programs as potentially transformative means for human heart regeneration. State-of-the-art lineage recordings, 3D imaging, and spatial multiomics in epicardioids will be used to dissect the fate acquisition mechanisms of the human embryonic epicardium and identify critical signalling pathways in health and disease. This in vitro approach will be complemented by charting a spatiotemporal, cross-species single-cell atlas of the cardiac injury response ex vivo and in vivo, including the first genetic lineage tracing of the adult epicardium in a large animal model. Finally, we will capitalize on the novel concept that CRISPR-mediated, temporal programming of the epicardiu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nurse Forecasting: Human Resources Planning in Nursing' (RN4CAST) targeting Seventh Framework.

assistant: **Abstract**

Current human resources planning models in nursing are unreliable and ineffective as they consider volumes, but ignore effects on quality in patient care. The project RN4CAST aims innovative forecasting methods by addressing not only volumes, but quality of nursing staff as well as quality of patient care. RN4CAST is a consortium of 15 partners that will quantify in 11 European countries-Belgium, Finland, Germany, Greece, Ireland, Poland, Spain, Sweden, Switzerland, Netherlands, UK - important unmeasured factors in forecasting models including how features of hospital work environments and qualifications of the nurse workforce impact on nurse recruitment, retention, productivity and patient outcomes. Three partners outside Europe - China, South Africa, and Botswana- provide additional perspectives. Innovative elements of the project include unique measures of workplace dynamics and patient outcomes. Nurse workforce planning initiatives at national and European levels will be reviewed and newly collected data added to enhance accuracy for nurse workforce management. Data collection focuses on general hospitals, which employ the majority of nurses, account for the largest number of medical errors and comprise the largest share of national health expenditures. Each European partner will conduct a study of 20 to 50 hospitals depending on country size yielding information on more than 350 hospitals including surveys from over 50,000 nurses and outcomes of tens of thousands of patients. European partners were selected by geographic distribution, membership duration in the EU, research expertise and availability of patient discharge data. University of Pennsylvania, USA, will contribute specialized research expertise derived from previous international research. RN4CAST will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HIV COEVOLUTION AND DRUG RESISTANCE' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

HIV-1 infects principally T4 lymphocytes. HIV infection has been reported to affect over 40 million people world wide, with 4 new million people infected each year.Regarding the effort put to stop HIV infection, there is no effective solution. During the last years, several studies have been done to find out more about the existence of intra-patient population structure (different viral population in different patient organs). In our previously reports we performed an in silico meta-analysis. The results highlight the detection of organ compartmentalization in proviral sequences of pol, gag and env HIV proteins. Those viruses found in nervous system (NS) and liver are significantly different from those found in the rest of the body organs, these differences have been associated to a different selection constraints acting on the virus in the different organs. This can be the cause of antiviral therapy failure.The binding of viral peptides with the Major Histocompatibility Complex and the recognition form the immune system T-Cells, are necessary to finish with viral infection in vertebrates. For this reason there is a coevlutionary history between viral particles proteins and cell receptors.The main aim of the project is the combination of in silico (principally) and in vitro/in vivo (when this is possible) approaches to be able to understand (i) evolution of the virus inside of the body, (ii) selection constraints forcing the differential evolution of the virus, (iii) understand and predict protein-protein interactions (between cell receptors and Env viral protein) performing molecular coevolutionary analyses. The information obtained from the project has it relevance at clinic ad economical level. If we are able to explain how virus evolves, how new resistant viruses ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Malopolska Researchers' Night 2014-2015'.

assistant: **Concept**

The project Malopolska Researchers' Night will be implemented in the years 2014 and 2015 respectively for the eighth and ninth time. The event has already permanently inscribed in the calendar of Malopolska scientific events, enjoying growing from year to year popular among participants and becoming one of the biggest Nights in Europe. In 2013, this event was attended by over 55 thousand people, while in the first year of the project (2007) the event was attended only by 3.5 thousand people. The event program specified in the application is even richer than before – it will take over 1 thousand activities, mainly interactive workshops, presentations, demonstrations and experiments as well as shows with the participation of scientists. It is estimated that 60 thousand people will participate in the events in 2014 and 65 thousand people in 2015. Malopolska Researchers' Night is to first of all show participants how interesting is the work of scientists and how fascinating they are people. Through fun, in accessible and understandable way for everybody, we want to show that all around us is the science, and that scientists in their laboratories are working every day to make our life better, easier and more modern. The main motto of the project for the years 2014 and 2015 will be to present the successes of Malopolska scientists working in international scientific-research teams. The event will be held in six cities of the Region: Krakow, Tarnow, Nowy Sacz and Niepolomice and - for the first time in 2014 - also in Skawina and Andrychow. In addition, it is planned the live broadcast from selected locations via event website. The program will be prepared by almost 900 researchers, more than 1 600 students, about 120 research groups from more than 30 partners. Thanks to the ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Centralized facility and concerted action on design, synthesis, evaluation and development of new antiviral compounds against AIDS'.

assistant: **Objectives**

To discover, as the result of a large-scale collaborative effort, new antiviral compounds as potent and selective inhibitors of HIV (Human Immunodeficiency Virus), to identify the molecular targets of the virus replicative cycle with which they interact, and to develop drug treatment regimens that would completely suppress or even knock out" the virus.This Centralised Facility/Concerted Action should be viewed as the continuation of the BIOMED l Centralised Facility/Concerted Action on the Design, Synthesis, Evaluation and Development of New Antiviral Compounds Against AIDS. This Centralised Facility is essentially aimed at the discovery of new antiviral agents as potent and selective inhibitors of HIV (Human Immunodeficiency Virus) that should be effective in the treatment of AIDS and may ultimately lead to a full recovery from the disease. To accomplish this task, we can count on the collaborative help of about 130 collaborative centers world-wide (about 70 belonging to the European Union), which will provide through chemical synthesis, or, where applicable, through extraction and purification from natural products, the candidate anti-HIV agents for a thorough evaluation of their antiviral properties, particularly their potency and selectivity against HIV. The anti-HIV activity will be determined in a variety of assay systems with different cell types (including peripheral Iymphocytes and macrophages) and different virus strains (including mutant strains resistant to the established anti-HIV drugs). In designing potential anti-HIV drug candidates, all major steps of the HIV replicative cycle will be envisaged as targets: virus adsorption, virus-cell fusion, viral uncoating, reverse transcription (viral RNA o proviral DNA), proviral DNA integration, transcription, tran