RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Protease Quenched Activity-Based Probes for Targeted Cancer Diagnostic and Therapy'.

assistant: **Innovation**

Cysteine proteases play pivotal roles in normal and disease processes. Alteration in cysteine protease expression and activity-pattern are the cause of various human pathologies. Several different cancers types over express members of the cysteine cathepsin proteases family. Previously we have designed and developed “smart” quenched Activity Based Probes (qABPs), that enable real time imaging of cathepsin activity in intact cells. These “smart” probes are fluorescently quenched until binding to an active protease, which causes them to become fluorescent. We have modified these qABPs enabling non-invasive imaging of cathepsin activity in cancer modules in living animals. I propose to generate novel type of ABPs that will target the cathepsin activity in tumors and will have combined imaging and therapeutic capabilities by using photodynamic therapy (PDT) strategies. Theses probes (called Photo Dynamic Activity Based Probes, PD-ABP) will allow concomitant non-invasive cancer detection and targeted treatment. Unlike traditional PDT, these probes would specifically target cancer cells, and the internal quencher would result in overall low light-induced toxicity from unbound probe. Moreover, these probes can be used for real-time tumor imaging prior to light activation, in order to better localize the subsequent photodynamic anti-cancer treatment. In this proposal we will design and synthesize PD-ABPs, we will study their biochemistry in-vitro and in cells and we will use the best PD-ABPs to image and cure cancer in small animals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Investigation of VEGF-C involvement in acquired metastatic properties of renal cell carcinoma following anti-angiogenesis treatments'.

assistant: **Innovation**

Abnormal vascular network formation is a prerequisite for tumor growth. This phenomenon has prompted the development of therapeutic approaches targeting molecules involved in the formation of pathological blood vessels such as VEGF and its receptors VEGFR1, VEGFR2 and VEGFR3. Although some patients benefited from such an approach, the majority of patients had a poor outcome through a transient decrease of the tumor/metastases accompanied by the selection of more aggressive tumors cells.Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults, responsible for approximately 80% of cases. It has been described as being among the most lethal of all the urological cancers. One major problem encountered in cancer patients, including RCC patients treated with anti-angiogenesis drugs, is the recurrence of metastases and even the development of new metastatic niches. Therefore, we postulate that the over-expression of VEGF-C, a growth factor for vascular and lymphatic endothelial cells, is responsible for tumor cells metastasis in response to anti-angiogenesis therapy.Hence, the objective of our project is to determine the molecular mechanisms leading to the expression of VEGF-C after treatment with anti-angiogenesis drugs. Because VEGF-C may constitute both a predictive marker and a new pertinent therapeutic target, its role in acquired metastatic properties of RCC following anti-angiogenesis treatments deserves to be rigorously investigated. We will focus on the transcriptional regulation of VEGF-C and the stability of its mRNA. These goals will be achieved through the use of relevant cellular and animal models.Since the anti-angiogenesis therapies lead to genetic adaptation of tumor cells, probably due to expression of receptors targeted by anti-angiogene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development of a single cell based biosensor for subcellular on-line monitoring of cell performance for diagnosis and healthcare'.

assistant: **Innovation**

Characterisation of cells is of crucial importance in various fields of health care. Since many biological processes are characterized by the sequential appearance of certain cell constituents that are present only during a short period of time statements based by taking only one time point into account are tainted with errors.The present goal is the development of a complete new concept and its implementation for nanotechnology biosensor-based integrated systems for health. The long-term objective of the present project is the development of a new medical instrument and/or intelligent diagnosis equipment for healthcare of the future, using advanced biological biosensors. It is based on the integration of technological developments regarding precision engineering, optical and computational methods. The sensor will result in a quantum leap regarding knowledge of the interactions between biological and non-biological systems.The biosensor that will be developed, is based on the on-line monitoring of traction forces that each cells transduce to surfaces through their with the cytoskeleton connected focal adhesion points (FA), being the connecting points between the cell and the material surface.The obtained biosensor can find its application in various fields of health care from characterising specific cells of the patient to optimise the treatment, as biosensor to detect the presence of bioactive medium components having a pharmacological or toxic effect on cells, as a completely new biological tool to describe and investigate time dependent biological processes (fundamental research in the direction of pharma/ toxicodynamics, drug effects, effects of gene defects, in combinations with transfected cells genomics, time evolution of subcellular processes, etc., etc.).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated communicating Solid-State Light Engine (ISLE) for use in Automotive Forward Lighting and information exchange between vehicles and infrastructure' (ISLE).

assistant: **Innovation**

This proposal aims to develop a new manufacturing technology to produce a new generation of headlamps for vehicles, which is the base for a future car-to-car or of car-to-infrastructure communication system. For this, a new one shot production process needs to be developed, combining LED chips into a packaging, which already forms the beam with minimized losses in a required way. This proposal aims at simplifying the production process of headlamps by: reducing the number of production steps reducing the components electric bulb, reflector and housing to just one injection-molded component reducing the production time reducing the manufacturing costs State of the art in lighting is an electric bulb. But these bulbs can not be modulated, so they are of no use for communication. White LEDs are existing today. They could serve for both purposes. A standard incandescent bulb achieves 20 lumens per watt (Im/W) while automotive Xenon lamp technology provides 90 Im/W. Solid-state technology currently achieves up to 40 Im/W in the laboratory quantities and about 20 Im/W in series production. New records are established in quarter year intervals. The theoretical limit of 200 Im/W- at half the theoretical limit - the solid-state source achieves greater efficiency than the best existing light source. More efficient lighting systems means enhanced brightness on the road while reducing fossil fuel emissions through lower power consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GlioDx - Blood platelet-based monitoring and treatment optimisation for glioblastoma patients' under Horizon 2020.

assistant: **Concept**

Glioblastoma (GBM) is a devastating primary brain cancer which affects about 230.000 people annually. The choice for treatment depends on the subtype of GBM. An accurate detection of tumour subtype is therefore essential for a personalised targeted treatment. Diagnosis, classification and treatment monitoring occurs currently by radiology and repeated invasive biopsies. There is a need for non-invasive, actionable biomarkers for early-stage diagnosis and disease monitoring.During our ERC research, we discovered that mRNA sequenced from tumour-educated platelets enables for pan-cancer, multiclass cancer and companion diagnostics. We were able to distinguish between primary and metastasised tumours in the brain and also establish the molecular subtype of the tumour. These findings provide strong support for using tumour-educated platelets as a biomarker for early stratification, diagnosis and prognosis for personalised GBM treatment.As a proof-of-concept of our innovative diagnostic tests, we will validate the proprietary algorithms underlying these tests specifically in GBM patients. To achieve this, we focus on the differentiation of glioblastoma subtype based on the platelet mRNA profile. In addition we will validate treatment monitoring and response prediction to an EGFR targeted drug in GBM patients.GlioDx will also assess the feasibility to commercialise the technology. The team has developed several business and IP models which need to be assessed thoroughly through in-depth market research and business planning activities. The results need to be consolidated into a strong business plan that will be presented to investors and strategic investors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Introduction of an electric energy power storage levelling module in the machine tools industry to unleash the enormous energy savings potential and significantly relieve the European power grid' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With 37% of the overall consumption of electrical energy, industrial production is one of the most energy-intensive sectors in Europe. A major driver of both, energy consumption and energy costs are machine tools used the processing of materials, esp. in the automotive, mechanical engineering and aerospace segments. These machine tools are not only consuming huge amounts of energy, they also cause frequent power peaks, thus requiring very high connected loads. These peak loads have a negative effect on the European power grid stability, therefore, the provision of such high connected loads is very expensive.As pioneer in the electrification of forming machine tools, EBM has developed Enerstor – an electric energy power storage levelling module. This modular energy storage solution can be directly connected to any kind of machine tool, thus significantly reducing energy consumption of the machine tool and entirely levelling power peaks. This solution directly addresses current user needs of the European industry, including reduced energy costs through lower consumption and connected loads, higher flexibility in production, less emissions, and decreased investment costs. It helps the European industry and especially the segment for machine tools to stay competitive. With over 1,400 companies in Europe, the machine tools industry currently worth 25 bn € is very important for Europe in terms of employment and wealth. Innovative solutions are therefore crucial to further extend the industry’s position in the global market.In the feasibility study, a detailed analysis of the best-fitting market segments within the machine tools market will be conducted, including the involvement of pilot customers for the validation of the business idea, as well as the elaboration of a thorou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ajax: Narratives, Textual Histories, Orientations, and Scholarly Strategies' (ANTHOS), addressing dissemination and exploitation.

assistant: **Impact**

ANTHOS (Ajax: Narratives, Textual Histories, Orientations, and Scholarly Strategies) reassesses conjectural emendation – the act of proposing corrections to faulty manuscript readings – as a central, creative practice of philology. Taking Sophocles’ Ajax as a pilot case, it digitises and encodes the unique Van Paassen Sophoclean archive (over 60,000 conjectures, 18th–20th c., expanded to date), producing the first interoperable dataset of conjectures on a classical author. This corpus provides the foundation for a scalable digital infrastructure applicable to any manuscript-transmitted tradition, since conjectural reasoning is universal across literatures. Four objectives structure the project: (1) corpus recovery and TEI/XML encoding; (2) historical and interpretative reconstruction of transnational editorial logics; (3) typological modelling and visualisation of conjectural reasoning; and (4) analytical synthesis in a prototype multi-text integrated into the Perseus Digital Library. The project not only documents outcomes of emendation but reveals the interpretative strategies, debates, and contexts that shaped them, creating a dynamic atlas of textual reasoning. Attention is given to gender, highlighting Dr. Liny van Paassen’s neglected contribution and the editorial treatment of female voices in Ajax. Interdisciplinary in scope, ANTHOS combines philology, intellectual history, and digital humanities and is embedded in a transatlantic partnership between Tufts and Verona. The fellowship provides advanced training in digital infrastructures, historiography, and project leadership, while ensuring transfer of knowledge through open science, teaching materials, and outreach. By recovering neglected archives, modelling interpretative logic, and releasing reusable digital
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'I-PRIMES: an Intelligent Power Regulation using Innovative Modules for Energy Supervision' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main objective of the proposal is the development of an hardware device able to implement an innovative power management (I-LPM) function for an aeronautical electrical network. The proposal is based on the two keypoints. First one concerns the I-LPM strategy for the specific application, that will be first derived and tested in a simulation environment. In a second phase the above strategy will be implemented, adopting semi-automatic techniques for translation of the simulation model into firmware. Second keypoint is about an EPC (Electrical Power Center) hardware extension that will be designed and realized, where a modular approach will be considered for the overall equipment implementation. Each cell will be composed by a programmable device, an interfacing stage and possibly by an innovative power device switching component. A “master” module will be able to implement the I-LPM concept and communicate with “slave” modules for correct energy management strategy implementation. Different types of “slave” modules will be considered, taking into account the necessity of I-LPM strategy implementation for both “fixed power” and “variable power” loads. A preliminary analysis phase will be conducted in order to analyze the fundamental requirements for the project objectives and derive the specifications set. After the models validation, it will be necessary to implement the derived models as real electronic components. Before integration on the ETB (Electrical Test Bench), the hardware performances will be verified towards the expected results, considering the requirements derived in the first stage as well as the obtained simulation results. Next, a complete test case set will be performed in order to evidence the expected results fulfillment. Finally, an optimization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Progressing a non-antibiotic antimicrobial treatment for Bovine Mastitis towards market - PanaMast' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The world is facing an antibiotics crisis, with resistant bacteria rendering current treatments ineffective. Novel, effective solutions are urgently required for this $40bn global market. Westway Health (WWH) is based in Galway, Ireland, and is on track to become a leading veterinary antimicrobials company in the EU. It has developed an innovative, non-antibiotic technology, effective at killing all bacteria, including antibiotic-resistant bacteria like MRSA, while not inducing resistance. WWH’s lead product in development is PanaMastTM LC, a breakthrough treatment of bovine mastitis, the most economically important infectious disease affecting the dairy industry. PanaMastTM LC will represent a step change in the way that dairy farmers manage mastitis, which affects 30% of the herd annually. It will: 1. Be the world’s first non-antibiotic medicine for mastitis, offering superior clinical outcomes and significant financial gains to end-users (€150/case); 2. Reduce wastage of milk and culling of cows; (3) Improve profitability and environmental performance on European farms and dairy processing sites. The innovation directly addresses the major global problem of antibiotic resistance, while providing a sustainable animal health solution that supports production of safe and high quality food. The Phase 1 PanaMast project was successfully completed ahead of schedule and on budget. It allowed WWH to: 1. Develop a regulatory roadmap detailing all steps required to progress from current stage of development (TRL7) to first sale of commercial product (TRL8); 2. Develop a robust commercial exploitation plan for PanaMastTM LC in EU and global markets; 3. Establish key strategic relationships to assist commercialisation of PanaMastTM LCThe Phase 1 results underpin this proposed pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Brextor - The horizontal forces concrete pile removal head for high-precision piles preparation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The safe connection between the concrete piles and the pile cap is crucial for the stability of a construction project, especially for heavy structures as bridges and high-rise buildings and/or projects in non-cohesive soils (sand, gravel, water). Damaging the reinforcement bars during the pile head removal can result in high financial loss, time waste and therefore, danger for the overall construction safety. Today’s solutions cannot guarantee a secure and efficient pile head removal, as they all apply vertical forces endangering the concrete structure. On top of that, high amounts of energy are lost during the operation and OPEX is very high.With Brextor we want to revolutionize the construction industry, by offering an innovative concrete pile milling head which applies horizontal forces to the pile and can thus control 100% the applied energy for an accurate and secure pile head removal minimizing the energy loss. Moreover, our method can guarantee an up to 4 times faster pile breaking at an up to 3.5 times lower OPEX. We also minimize the human risk factor as minimum worker intervention is required. We started working on Brextor since 2007, and our current prototype has attracted the interest of the largest Swiss construction companies, having already used the first version of our technology in >100 sites in the country, including important construction as the Roche Tower in Basel in 2018. It has also been pilot used in Germany and Philippines. We will sell Brextor to construction companies and building contractors via direct sales for the Swiss region and distributors. With an additional investment of €2.5 million, we aim to sell ~1,100 units in a 5-year period (2022-2026) creating a business opportunity of €81.5 million and generating an astonishing ROI2026 of 5.