RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Uncertainty Management for Robust Industrial Design in Aeronautics' (UMRIDA).

assistant: **Concept**

Virtual prototyping (VP) is a key technology for environmental friendly and cost effective design in the aircraft industry. However, the underlying analysis and simulation tools (for loads, stresses, emissions, noise), are currently applied with a unique set of input data and model variables, although realistic operating conditions are a superposition of numerous uncertainties under which the industrial products operate (uncertainties on operational conditions, on geometries resulting from manufacturing tolerances, numerical error sources and uncertain physical model parameters). Major new developments in this new scientific area of Uncertainty Management and Quantification (UM and UQ) and Robust Design methods (RDM) are needed to bridge the gap towards industrial readiness, as the treatment of uncertainties enables a rigorous management of performance engagements and associated risks. This is the main objective of the UMRIDA project, which has the following action lines:• Address major challenges in UQ and RDM to develop and apply new methods able to handle large numbers of simultaneous uncertainties, generalized geometrical uncertainties in design and analysis within a turn-around time acceptable for industrial readiness in VP systems.• To respond to the validation requirements of UQ and RDM, a new generation of database, formed by industrial challenges (provided by the industrial partners), and more basic test cases, with prescribed uncertainties, is proposed.• The methods developed will be assessed quantitatively towards the industrial objectives on this database, during the project and at two open workshops. The gained experience will be assembled in a Best Practice Guide on UQ and RDM.It is anticipated that the UMRIDA project will have a major impact on most of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International conference on transmissible spongiform encephalopathies' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

We propose to organise a conference on transmissible spongiform encephalopathies (TSEs), to be held over three days in September 2002 in Edinburgh. The objectives are to disseminate recent key findings in the areas of pathogenesis, diagnostics, therapeutics and epidemiology, and to provide a platform to update workers in the field on TSE research. Many of the leading researchers in this field have provisionally agreed to present their current work. We intend to provide bound copies of abstracts which will provide a useful source of current research. Edinburgh is a major focus of TSE research and has many international collaborations, particularly within the EC .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AI4SoilHealth: Accelerating collection and use of soil health information using AI technology to support the Soil Deal for Europe and EU Soil Observatory' to be submitted under Horizon Europe.

assistant: **Abstract**

The objective of AI4SoilHealth is to co-design, create and maintain an open access European-wide digital infrastructure, compiled using state-of-the-art Artificial Intelligence (AI) methods combined with new and deep soil health understanding and measures. The AI-based data infrastructure functions as a Digital Twin to the real-World biophysical system, forming a Soil Digital Twin. This can be used for assessing and continuously monitoring Soil Health metrics by land use and/or management parcel, supporting the Commission’s objective of transitioning towards healthy soils by 2030. The project is divided into seven (7) work-packages including: (WP2) Policy and stakeholder engagement - networking and synchronising with EU and national programmes, (WP3) Soil health methodology and standards - developing/testing methodology to be used by WPs 4-6, (WP4) Soil health in-situ monitoring tools and data - developing field and laboratory solutions for Observations & Measurements, (WP5) Harmonised EU-wide soil monitoring services - developing the final suite of tools, data and services, (WP6) Multi-actor engagement pilots - organizing field-works and collect users' feedback, (WP7) Soil literacy, capacity building and communication - organizing public campaigns and producing educational materials.Key deliverables include: 1) Coherent Soil Health Index methodology, 2) Rapid Soil Health Assessment Toolbox, 3) AI4SoilHealth Data Cube for Europe, 4) Soil-Health-Soil-Degradation-Monitor, and 5) AI4SoilHealth API and Mobile phone App. Produced tools will be exposed to target-users (including farmer associations in >10 countries), so their feedback is used to improve design/functionality. Produced high-resolution pan-European datasets will be distributed under an Open Data license, allowin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards Elimination of Growth Retardation in Marine Recirculating Aquaculture Systems for Turbot' under Sixth Framework.

assistant: **Concept**

Recirculating Aquaculture Systems RAS offer significant advantages over open aquaculture systems. These advantages are heavily underutilized because application of RAS is limited. Growth retardation is the problem and until it is solved economic feasibility of aquaculture in RAS remains marginal significant aquaculture production in RAS will not be established and the advantages of RAS remain under-utilized. Growth retardation has been observed for most species cultured in RAS but the causes remain obscure. The turbot industry was the first aquaculture industry to be heavily affected by growth retardation as it was the first marine aquaculture industry that applies RAS on a large scale Growth of turbot in RAS is 15 20 lower and feed conversion rates are 0 3 higher compared to flow through systems. Individual farms have tried but were unable to solve the problem by themselves. Therefore they need to join forces with other farms and RTDs in this project. Without elimination of growth retardation it is either back to flow through systems or an insecure and marginally feasible future with RAS. We hypothesise that growth retardation is due to accumulation of growth inhibiting factors GIF in the culture water Both the fish and bacteria are believed to produce GIF.The objectives of this project are Exchange analyse and document the results of obtained by individual farm experiments over the years. Establish the production presence and effects of GIF by the fish and bacteria Investigate means for GIF removal and prevention of its production. Establish the physiological status of fish cultured in RAS Overall it is foreseen that this project will result in a large increase of our knowledge and understanding of growth retardation in RAS This would be a large step towards eliminati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Mechanism and significance of de novo gene methylation during reproduction in Marchantia'.

assistant: **Concept**

DNA methylation plays fundamental roles in gene regulation and cell identity in plants and animals. However, these two kingdoms exhibit distinct methylation patterns and reprogramming of methylation during development occurs in different ways. I have exciting evidence from the emerging model plant system Marchantia polymorpha of de novo DNA methylation at thousands of genes in the embryo that is analogous to gene methylation established in the oocyte of mammals. A subset of these genes are also methylated in the Marchantia male sex organ prior to fertilisation and are enriched for roles in hormone signalling, epigenetics, and developmental transitions, indicating parental imprinting events important for embryo development. I propose to conduct a targeted dissection of this phenomenon. I will be hosted first by Prof. Ecker (Salk Institute, US), who is a world leader in single cell epigenomics. I will carry out high-throughput single cell methylomics and transcriptomics in combination with other cutting-edge molecular techniques to precisely determine the developmental processes undergoing gene methylation reprogramming as well as the underlying epigenetic players involved. In the return phase, I will be hosted by Prof. Solano (Centro Nacional de Biotecnología, Spain) who is an expert in motif analysis and Marchantia hormone biology. With his expertise I will investigate the methylation targeting mechanism and will utilise methylation loss lines to confirm the role of gene methylation in transcriptional regulation as well as development, with a focus on ethylene signalling. This proposal represents a state-of-the-art class of study of DNA methylation through which I will broaden my scientific knowledge, develop complementary skills such as lab management and science outre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The molecular interface between cell cycle and redox regulation' (REDOXCYCLE), addressing dissemination and exploitation.

assistant: **Impact**

Aberrant cell cycle and redox regulation are hallmarks of cancer. While cell cycle and redox signaling are extensively studied, it remains poorly understood how both communicate in physiological conditions. One reason is the emphasis on oxidative stress as a signature of cancer cells. Only recently, emerging evidence indicates that reactive oxygen species (ROS) also function as signaling molecules in physiological conditions, and that some of their key targets are cysteine residues on cell cycle proteins. This indicates that more subtle changes in redox signaling can affect proliferation and have the potential to promote cancer. I propose to investigate how the cell cycle and redox homeostasis are coupled in a spatial-temporal manner and reveal the differences that distinguish physiological from pathological redox signaling. I will use genetic engineering to label endogenous cell cycle and redox proteins with fluorescent markers. I will measure relative and absolute molecule numbers of cell cycle and redox proteins, relate this to cell cycle and redox states, and determine the cysteines modified on cell cycle proteins. To functionally investigate the pathological potential of identified modifications I will use mammary 3D cell culture – a model that recapitulates many aspects of mammary architecture in vivo and is used to study early steps of breast tumorigenesis.I expect our work to provide us with a quantitative description of the interface between cell cycle and redox regulation. Although intracellular cell behavior is never completely deterministic, a reasonable quantitative model should be predictive to some degree and reveal how different levels of ROS can affect cell cycle decisions. Shedding light on the cell cycle targets of ROS will indicate the nodes that can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Objective delirium detection with an innovative EEG-based spot monitor' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Delirium –an acute decline in cognitive functioning– is common, serious, frightening, costly and sometimes fatal. Delirium is a great burden for patients because of horrifying hallucinations and impaired outcome and increased risk on dementia. Delirium stresses society because of increased healthcare costs. This is due to prolonged length of hospital stay, and increased rate of discharge to a nursing home thereafter. Costs due to delirium total to €134 billion/year in Europe alone, equaling costs associated with diabetes. Delirium particularly affects hospitalized elderly with reported incidences of 50-80% on the Intensive Care Unit (ICU), and 10-40% in surgical patients. Because of our aging society, patients at risk for delirium will double in the next decades.  Despite its frequency and impact, delirium remains underdiagnosed and therefore undertreated. Delirium is not recognized in 50 - 70% of the cases, which impairs outcome. Early and objective detection of delirium is an unmet clinical need.  Mount Medical (MM), an SME specialized in medical devices, will create and commercialize the world’s first biomarker based device to detect delirium. UMC Utrecht (NL) showed that 1 minute recording of brain activity (EEG) with only 3 electrodes and automated processing could very well identify patients with delirium. A license on the patent will be granted to MM.  Yearly, millions of patients are at risk of delirium that need to be monitored 3 times per day. This generates a €1.4 billion market in the EU and the USA, as for every measurement, a disposable electrode patch is necessary.  A 6 months Phase 1 budget enables biomarker validation and development of noise reduction technology to show technical feasibility, and to commit customers into an Early Access program for mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'How visual action shapes active vision' (VIS-A-VIS), addressing dissemination and exploitation.

assistant: **Impact**

A key component of visual perception is our ability to move: In a flick of the eye, we see the time on the watch, and we quickly turn around if we hear our name in the crowd. Whereas other movements aim to change the state of the world, visual actions shift our eyes, heads, and bodies to align the retina with currently relevant parts of the world. Although they vitally extend the scope of high-acuity vision, their immediate sensory consequences have challenged scientists for centuries: How do we not experience the brisk motion of the entire scene on the retina every time the eyes move (perceptual omission)? How does the brain keep track of objects changing retinal locations across consecutive glances (object continuity). And how do we routinely attribute retinal motion to our own movements rather than to motion in the world (sense of agency). To explain these phenomena, research and theories across disciplines have focused on how the brainusing its knowledge about ongoing movement planspredicts and compensates for undesirable side effects of visual actions.   I pursue a radically new perspective based on a key insight: Visual actions follow distinct kinematic rules, and as every visual action translates directly into a movement of the world on the retinal image, these rules also directly govern the sensory input. Their sensory consequences can thus be distinguished from motion in the world based on the rules they follow. In embracing this idea, I challenge the long-standing idea that visual actions are a nuisance to sensory processing and propose instead that they support core functions in active vision. In an interdisciplinary team, we will leverage innovative technology, state-of-the-art psychophysical tools and robust experimental protocols to find out if and how the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular genetic and functional studies of Lafora Progressive Myoclonus Epilepsy' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Progressive Myoclonus Epilepsy (PME) of the Lafora type is an autosomal recessive disease, which presents in teenage years with myoclonia and generalized seizures leading to death within a decade of onset. Using a genetic and functional genomic approach we are studying the biology of LD (Lafora Disease) with the goal of being able to offer better treatment and possible a cure for this fatal disease.Using a positional cloning approach, two genes causing LD, EPM2A on chromosome 6q24 and recently EPM2B on chromosome 6p22.3 (the applicant is one of the authors), were identified. EPM2A encodes a novel protein, laforin, with the only clue to its function being that it contains a carbohydrate-binding domain (CBD) in the N-terminus and a protein tyrosine phosphatase (PTP) domain in the C-terminus.EPM2B encodes a novel protein, malin, containing a zinc finger of the RING type in the N-terminal half and 6 NHL-repeat domains in the C-terminal direction. Three laforin interacting proteins were recently isolated, EPM2AIP 1 of unknown function, HIRIP5 that may be involved in iron homeostasis, and R5, a glycogen targeting regulatory subunit of Phosphoprotein Phosphatase-1, but their roles in the disease still need to be clarified.To gain insight into the possible role of these proteins in the pathology of the disease we are working to verify whether they are part of the same pathway and to identify other interacting proteins using yeast two-hybrid screens, immunoprecipitation and GST pull-down experiments.During the course of the study we have identified that further genetic heterogeneity exists for LD (some families do not harbour mutations in EPM2A and EPM2B) and we are currently working to identify the third disease-causing gene (EPM2C).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'COst REduction and increase performance of floating WIND technology' (COREWIND).

assistant: **Innovation**

Floating offshore wind is still a nascent technology and its LCOE is substantially higher than onshore and bottom-fixed offshore wind, and thus requires to be drastically reduced. The COREWIND project aims to achieve significant cost reductions and enhance performance of floating wind technology through the research and optimization of mooring and anchoring systems and dynamic cables. These enhancements arisen within the project will be validated by means of simulations and experimental testing both in the wave basin tanks and the wind tunnel by taking as reference two concrete-based floater concepts (semi-submersible and spar) supporting large wind turbines (15 MW), installed at water depths greater than 40 m and 90 m for the semi-submersible and spar concept, respectively. Special focus is given to develop and validate innovative solutions to improve installation techniques and operation and maintenance (O&M) activities. They will prove the benefits of concrete structures to substantially reduce the LCOE by  at least15% compared to the baseline case of bottom-fixed offshore wind, both in terms of CAPEX and OPEX. Additionally, the project will provide guidelines and best design practices, as well as open data models to accelerate the further development of concrete-based semi-submersible and spar FOWTs, based on findings from innovative cost-effective and reliable solutions for the aforementioned key aspects. It is aimed that the resulting recommendations will facilitate the cost-competitiveness of floating offshore wind energy, reducing risks and uncertainties and contributing to lower LCOE estimates.COREWIND aims to strength the European Leadership on wind power technology (and specially floating). To do so, the project consortium has been designed to ensure proper c