RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Flame-made calcium phosphate nanoparticles for biological drug delivery toward healing chronic wound'.

assistant: **Concept**

The increasing number of chronic wound cases, most frequently attributed to antibiotic-resistant bacterial infections, has set an urgent alarm since it causes low quality of life and even fatal complications to thousands of patients as well as burdens the healthcare systems globally. Antimicrobial biological drugs, also called biologics, are proposed to address the emerging and unmet threat of antibiotic-resistant bacteria in wound infections by developing antibiotic-free treatments with low immunological risk. Despite having maximal antimicrobial effect, biologics efficiency in infection treatment and wound healing is compromised due to their limited circulation half-life and susceptibility to environment and wound related factors. Hybrid nanoformulations (HNs) based on inorganic nanoparticles (NPs) are developed to perform biologics delivery by securing the integrity of their vulnerable structure and efficiency while they exhibit great potential in biomedicine as drug nanocarriers due to their stability, small size, and extremely high surface area. Here, we propose the synthesis of biocompatible and healing-promoting Calcium Phosphate (CaP) NPs with a nanomanufacturing process famous for its scalability and reproducibility, Flame Spray Pyrolysis. The as-prepared CaP NPs will be loaded with the biologics, peptide LL-37 and enzyme Lysozyme, to form novel hybrid drug delivery nanosystems. Synthesis parameters of CaP NPs and HNs nanomanufacturing protocols will be studied and their physicochemical characterization will be performed. The stability, the antimicrobial activity and the cytocompatibility of the HNs will be examined with in-vitro assays. Finally, the effectiveness of HNs in wound infections treatment and wound healing promotion will be tested ex-vivo. This proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Leveraging a novel platform technology to develop a first-in-class immunotherapy for Celiac Disease' (SOMIT), addressing dissemination and exploitation.

assistant: **Impact**

Celiac Disease is a debilitating autoimmune disorder that is caused by intolerance to gluten. Although it is the most common genetically-based food intolerance in the world, there are currently no therapeutics available to treat patients. In this project, Allero Therapeutics will collaborate with two leading research institutes (Leiden University Medical Center from the Netherlands and the Veterinary Research Institute from the Czech Republic) to develop a first-in-class therapeutic against Celiac Disease. Specifically, this novel therapeutic consists of an antigen-specific immunotherapy combined with tolerizing agents, which will be delivered to the oromucosa via a proprietary sublingual mouth patch. This project consists of a 6-month multi-disciplinary feasibility study that will:(1) experimentally demonstrate in vitro and ex vivo Proof of Principle for the novel therapeutic; (2) research all required (pre)clinical development to build a detailed roadmap for navigating the regulatory landscape; (3) strengthen and expand the current IP position; and (4) consolidate all current and future findings into an investor-ready Business Plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of innovatrice structural concepts for advanced passenger vessels (DISCO)' (DISCO) under Fifth Framework.

assistant: **Objectives**

The development in the cruise ship industry has been very fast during the last 10 years, putting many challenges on everyone involved in the business. Modern architectural design and new safety regulations demand more complicated and sophisticated structures, which have a strong influence on the ship hull structural concept. The objective in the DISCO project is to develop new global and local structural solutions that will better meet the needs. At the same time the design and construction of these concepts must be managed by the yards with limited economical, technical and timing risks. Methods and programs to analyse and verify the solutions will also be developed. The project will contribute to the future success of the European cruise vessel constructions and help the yards to maintain their position in the market. The development in the cruise ship industry has been very fast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Study and development of a new sandwidn plastic multi-injection system with bi-material combination for the automobile industry with the possibility of using recycled plastics in the process'.

assistant: **Innovation**

The objectives of the research is to create new possibilities in the plastic multi-injection process with new sandwich bi-material capacities in the automobile industry - The aim of the research project is to develop moulds and prototypes of this new product and test it for its best economical and technical definition and then, try to specify the necessary machine and equipment for, after the research, manufacture this equipment and process lines to be able to develop a future industrialisation first for the automobile market and then for various other markets (packaging, furniture, handling, aeronautics, trains, construction) - The interest of such a research is to create a new product and process replacing old technologies with the here-after described improvements and benefits and also the important possibility to process car- parts such as dashboards with a new bi-material injection permitting the new possibility of using recycled plastics for the core of the part and regular raw material for the external aspect . - The SME proposers - manufacturers of machine equipments and specialist of heating equipments - would be interested to contribute to this project and work with RTDs dedicated to research on heating processes and automation technologies, on injection distribution principles, in fluid and molecular chain dynamics and in refrigeration technologies and a knowledge and with a practice in prototyping and performing tests
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of critical flux phenomenon during microfiltration' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Taking in consideration the current state-of-the-art, the main objectives of the current project are the measurement of the critical flux for a variety of different materials, membranes and hydrodynamic conditions, which will lead to the understanding of the rejection of macromolecules by microfiltration membranes and how this rejection is influenced by the presence of larger particles. The staged objectives are: 1.- Determine fouling of small silica particles (5nm) in the presence of larger silica particles of size range around 1 micron These studies have the purpose of investigating the interactions from a physical viewpoint between the larger and the small particles; 2.- Determine the effect of surface interactions on rejection. With that aim the smaller silica particles will replaced by defined proteins and the previous experiments repeated; 3.- With the knowledge gathered during the two previous stages it will be evaluated the rejection of protein by a microfiltration membrane from a cell broth containing both micro- organisms (replacing the larger silica particles) and protein when operating at subcritical flux conditions. The results expected are of major interest to industrial processes that use (or can potentially use) membrane microfiltration I particle or cell harvesting (namely for wine and beer clarification, microalgae harvesting, drinking water filtration) or for c culture in membrane bioreactors (namely for biological purification of drinking water and wastewater treatment, or production of extracellular enzymes). Training content (objective, benefit and expected impact) This project will require both the use of engineering and biological knowledge and tools in a integrated way. This will be great benefit as a scientific training for the applicant. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comprehensive assessment of hazardous effects of engineered nanomaterials on the immune system' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Engineered nanomaterials (ENs) present tremendous opportunities for industrial growth and development, and hold great promise for the enrichment of the lives of citizens, in medicine, electronics, and numerous other areas. However, there are considerable gaps in our knowledge concerning the potential hazardous effects of ENs on human health and the environment. Our EU-US partnership is committed to filling these knowledge gaps through a comprehensive assessment of ENs, with particular focus on effects on the immune system. The immune system is designed to respond to pathogens and foreign particles, and a core concept underpinning the current project is that the recognition versus non-recognition of ENs by immune-competent cells will determine the distribution as well as the toxicological potential of these materials. Our multidisciplinary consortium will focus on the procurement, synthesis and detailed physico-chemical characterization of representative categories of ENs, and the monitoring of potential hazardous effects using an array of in vitro and in vivo systems, as well as transcriptomic and oxidative lipidomic testing to determine specific nanotoxic profiles (signatures) of these materials. The final and integrative component of our research project is risk assessment of potential adverse effects of ENs on human health, and the dissemination of our findings. Through our comprehensive approach, which combines analytical procedures from many different disciplines and leading experts from several national institutes devoted to occupational and environmental safety, we aim to establish a panel of read-out systems for the prediction of the toxic potential of existing and emerging ENs, thus enabling a continuous and sustainable growth of the nanotechnologies. Overall,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart optical sensor system for the real time detection of decorations defects of traditional ceramic tiles' under Fourth Framework.

assistant: **Concept**

The objective of this project is to develop a real time automatic system (STILE) for detection of decoration defects in ceramic tiles to provide the manufacturing SMEs with an efficient, cost-effective in-line tool for monitoring of the tiles production. The proposed system will reduce the scraps and will reduce the production cost up to 30 per cent in the short term. The surface control of tiles is presently performed by human operators. This solution is expensive and not reliable. Attempts have been made to develop automatic systems for the control of the surface quality of tiles, but the computing time required to analyze the image was too long and therefore not compatible with the production rate. STILE is based on the technology of the smart optical sensors. This patented innovative technology, which was originally developed for space applications, is based on the combination of optical sensor and digital processor on the same semiconductor chip. The architecture of the chip offers the possibility to perform image operations (including digitalization, filtering, edge detection, thresholding, thinning, etc.) directly on the chip, allowing a very effective time saving in comparison with conventional image data processing. The smart optical sensors will be further developed and integrated in an inline control system which will include ad-hoc image analysis software and illumination devices. The STILE system will be: much faster than existing systems; cheap and therefore particularly suited to SMEs; very reliable. The effect of this development on the core group of SMEs will be to significantly increase their markets in the supply of ceramic tiles and of control equipment, depending on their position in the supply chain. It will also have a positive social impact becau
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EEN Northern Netherlands: enhancing the innovation capacity of SMEs' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

EEN Northern Netherlands offers the proposal for the H2020 programme 2017-2018. This proposal concerns work package 4 for both years as mentioned.In the North of the Netherlands around 3000 companies have received a NIOF grant, which is a grant for innovative companies. Therefore, it can be said that the innovating potential of companies in the North of the Netherlands is rather high. However, this potential is not optimally exploited. Therefore, EEN NN wants to assist the SMEs in the North of the Netherlands with their innovation management. First of all, EEN NN will establish Key Account Management for the beneficiaries of the SME Instrument in the North of the Netherlands. This service includes the identification of weaknesses in innovation capacities, find suitable coaches for the relevant SME and accompany the SME through the SME Instrument project. Secondly, EEN NN will provide new EEN services for the enhancement of the innovation capacity of SMEs in the North of the Netherlands. This includes the assessment of the current status of the innovation management capacity of the beneficiary and consequently performing a needs/gaps analysis and development of an action plan to increase the SMEs innovation management capacities. This action plan will be implemented and EEN NN will initiate and guide next appropriate steps.The objective for EEN NN is to assist at least twenty SMEs from the North of the Netherlands region with these services. We expect to deliver the KAM services to five SMEs and the EIMC services to fifteen companies.


**Keywords:** Key Account Management, Enhancing SME innovation capacity, innovation, coaching, SME Instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'mAlaRIa Sex dEtermination' (ARISE), addressing dissemination and exploitation.

assistant: **Impact**

Malaria is caused by parasites of the genus Plasmodium. Whilst the disease is caused by asexual parasites, only sexual forms are capable of transmitting the infection to mosquitoes. Sexual forms arise from a small subset of blood-stage parasites which divert from the cycle of asexual replication and embark on a sexual developmental trajectory. Targeting the small population of parasites transmitted to mosquitoes would provide a powerful malaria control method. Although several genes have been found to have sex-specific roles, the molecular basis of the sex-determining mechanisms of Plasmodium into one or the other sex is mostly unknown.In this proposal I will apply innovative approaches to uncover the pathway of sex-determination in P. falciparum, in both lab-adapted parasites and wild parasite populations.  Specifically, I will (i) determine the earliest events in sexual dimorphism using single-cell transcriptomics (scRNAseq) in a lab-adapted P. falciparum strain (NF54); (ii) understand determinants of malaria sexual determination in wild parasites by harnessing the power of scRNAseq; (iii) identify factors that influence determination into male or female gametocytes in natural parasite populations obtained from infected carriers.My supervisor, Dr Talman, is a leading figure in Plasmodium transcriptome analysis and sexual biology of the parasite. He has recently set up his group in Montpellier at MIGEVEC, one of the top IRD Centres in France. MIVEGEC has a unique and long history of supporting research and provides the best environment to conduct cutting-edge research in the lab as well as in challenging conditions in malaria endemic countries. Although this project represents an ambitious undertaking, I am confident my strong previous experience in malaria research an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards a typology of Visigothic script: the Beatus British Library Add. 11695 and its potential for dating and localising Visigothic script manuscripts' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main aim of the proposal is to establish a point of reference for the analysis of Visigothic script, the primary carrier of Latin writing in the Iberian Peninsula from the 8th to the 14th centuries. To date, most palaeographical analysis of Visigothic script has been conducted using a traditional methodology and following heterogeneous criteria, which has led to subjective results difficult to share or evaluate. In contrast, my research will create a computerised database of quantitative data by applying a specially designed method, a starting point that will allow codices written in Visigothic script to be described, compared and placed in their socio-cultural context. Innovative techniques for digital analysis of manuscript sources that will be acquired in the host institution will allow me to gain new insights into the analysis of the script while opening new avenues of research by applying digital tools to its study. The knowledge thus generated will be of great practical importance for future palaeographical and textual research establishing criteria upon which advanced studies can build. It will offer a means of understanding the script, its manuscripts, and its cultural context. The study builds on the systematic analysis of one of the few codices written in this script that can be dated and geographically located with certainty: the copy of the Apocalypse of Beatus of Liébana kept at the British Library (Add. 11695). I aim to achieve six specific objectives: A) Manual palaeographical study: (1) to determine how many scribes intervened in the copy of the codex, their graphic characteristics, (2) evolution, and (3) cultural context. B) Digital palaeographical study: (4) to apply and evaluate computer-assisted techniques to the study of Visigothic script, (5) t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Digital Economy: Policy Exchange and Development for SMEs'.

assistant: **Innovation**

DEEDS will ensure an open Forum of European executive policy makers (policy Group) stimulating, discussing, exchanging, and monitoring public policies related to the major issues of the digital economy, focusing on the uptake of electronic business practices by SMEs. The Forum is the follow-up of the Policy Group set up within the G7 Pilot Project A Global Marketplace for SMEs (1996.1999), co-ordinated by the European Commission, which has contributed -via the exchange of information, experience and best practice- to significant progresses and convergence in the policy making related to Electronic Commerce and SMEs. The objective of DEEDS is to address the demand to keep alive the network of European executive policy makers and advisers (from governments, development and technological agencies and SMEs associations), and to extend it to other countries-networks in Central and Eastern Europe, the Mediterranean, and Latin America. DEEDS is to provide scientific and technical assistance to the European Policy Group, to promote international co- operation on digital economy-SME policy issues with emerging areas, to maintain a close link and stable communication with IST-Key Action 2, providing input and feedback to the policy marking process of the European Commison.Objectives:General objective: to increase participation of SMEs in the digital economy within the EU, the new accession countries and other developing economies, and to contribute to the development of appropriate policies at local, regional, national and trans-national levels. Specific objectives:1. Identification of emerging change factors and new areas of policy related to SME in the digital economy.2. Strengthen the EU network of resources contributing to the policy development monitor the evolution of elect