RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innate immune recognition of intracellular DNA as 'stranger' and 'danger' signal' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The innate immune system provides an immediate response to infection and injury. It relies on the detection of pathogen-associated molecular patterns (PAMPs), molecular hallmarks of infection which are shared amongst different pathogens but are absent from healthy host cells. The  detection of intracellular DNA as PAMP has emerged a key event in the innate immune response to DNA viruses, retroviruses and intracellular bacteria. In some circumstances the body’s own DNA can also be also detected as a danger-associated molecular pattern (DAMP), e.g. when DNA from dying cells is not cleared effectively, and this can play a role in the development of autoimmune conditions such as systemic lupus erythematosus.One of the responses to foreign DNA is the secretion of interferons and pro-inflammatory cytokines, which then help to establish an antiviral state in the infected cell and its neighbours, and alert more specialised immune cells to the danger. Several proteins have been proposed to act as interferon-inducing DNA receptors, including most recently the enzyme cyclic GMP-AMP synthase, which provides a particularly elegant signalling pathway through production of cyclic GMP-AMP as second messenger. However, it is no yet know whether other receptor proteins also utilise this signalling pathway, how signalling is regulated, and how foreign DNA is distinguished from the cell's own genome.The objectives of this project are:1.) To test the involvement of DNA receptors in the recognition of DNA as 'stranger' and 'danger' signal in human cells2.) To examine the interplay between DNA receptor candidates3.) To identify novel regulators of the DNA-induced signalling pathway4.) To define the nature of the DNA ligand that is recognised by innate immune receptorsBy elucidating the molecu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Urban soils as a source and sink for pollution : towards a common european methodology for the evaluation of their environmental quality as a tool for sustainable resource management' under Fifth Framework.

assistant: **Concept**

The aim is to identify soil quality parameters and their use in urban areas to provide local, national and European authorities with decision support tools for sustainable planning and management of the soil resource in European cities. A comprehensive database of environmental and socio-economical data will be compiled, and general soil description parameters will be determined, as well as specific data for various inorganic and organic pollutants. A Decision-Support Tool for evaluation of soil quality will be developed, validated, and offered to local administrations for the correct planning and sustainable management of the soil resource.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'ACcelerate Trust in digital life Organisation and Relations'.

assistant: **Innovation**

Trust is an essential pre-requisite for connecting people in effective transactions. It builds in our society on elements like security, privacy, transparency, accountability and reputation.<br/>European strategy must aim at a strong competitive position in producing innovative solutions that bring new attractive ways of living and working that are perceived as trustworthy. They must ensure an experience of simplicity. Now it is time to address the fundamental societal issues raised by the introduction of digital technologies, by bringing together European stakeholders to promote trust in digital life.<br/>On 24 November 2008, Philips, Microsoft, Nokia and Gemalto took the initiative to establish the Trust in Digital Life Partnership. The coordination action ACTOR supports the TDL Partnership raising awareness of research and its results of trustworthy ICT. ACTOR supports the partnership in establishing a network by involving additional members for the definition of a SRA and implementation through research projects.<br/>The objectives of the proposed CA project ACTOR are focussed on:- Establishing a multidisciplinary partnership- Broad support to the TDL research roadmaps for longer-term research in the field of trustworthy ICT- Bundling and coordinating the effort of the Partnership members to develop a promising and ambitious SRA and Work plan for TDL.- Identification of a balanced portfolio with concrete project ideas for public funded research and innovation projects.<br/>ACTOR starts with a preparation phase to implement the required procedures, technical infrastructure and a collaboration framework and governance structure. Subsequently an initiation phase is envisaged where approximately 20-40 additional partnership members are invited to participate in the deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Conversion of Recycled Carbon Fibre Yarn and Tape Into High Value Fabrics and Materials' (HVRCFM).

assistant: **Concept**

The use of Carbon fibres is becoming widespread throughout the developing and developed world. As the use continues to grow, methods of recycling the waste materials are being developed. Whilst methods exist to recycle materials containing Carbon Fibre, these are not high value and tend to involve crushing and burning, which themselves are not environmentally friendly. This proposal will highlight the use of yarns, tapes and consolidated Matt virgin fibre materials for use in higher value recyclate with better properties which will substitute current materials with lighter, more efficient recycled materials. A number of commercially available polymer fibres soluble in epoxy based resin are available for use in thermoset composite manufacture (eg PEI, PES). These matrix soluble fibres can be blended with chopped recycled carbon fibre or waste carbon fibres to produce hybrid spun yarn to be achieved high performance thermoset composite form low value materials. The main benefit of this technology is uniform blending of recycled CF with resin soluble fibres, which will be dissolved in the epoxy resin during composite fabrication.  It is expected that by integrating the recycled fibres into current state of the art materials development, a wide range of high value, lower carbon footprint materials can be developed. Currently the ability to manufacture woven fabrics in 2 Dimensions and 3 Dimensions is available, as well as Multiaxial NCF materials. This ability to convert a wide range of substrates into useable fabrics and materials will provide better opportunities for realizing the higher value available from the recycled fibres. Having the experience of handling and converting high modulus, brittle materials into specialized fabrics, and the ability to create performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global Alliance for Chronic Diseases Secretariat' in the context of a Horizon 2020 call.

assistant: **Objectives**

The GACD is the first collaboration of international research funding agencies, which aims to coordinate research activities that will address, on a global scale, the prevention and treatment of chronic non-communicable diseases with a particular focus on the needs of low- and middle-income countries (LMICs) and vulnerable populations in developed countries, with targeted support for researchers in and from these communities. The GACD Secretariat aims to coordinate among the GACD members the next GACD chronic disease research programme and the process for the call for applications, as well as coordinate among the GACD members and participating research teams the joint activities of the research programmes. The recommendations reached are expected to have a fundamental value for the future orientation of public health research policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Static and quasi-static errors measurement and compensation in milling machines (SEC & TEC)' in the context of a Fifth Framework call.

assistant: **Objectives**

Industrial Need: Actual milling machines must follow a repeatable and accurate behavior to substitute grinding operations (users often speak about 15µm/m precision requirements on medium/big machines). Two major sources of inaccuracy are: the physical effect of temperature on machine structures extensions; the geometrical precision of part and the deformations caused by weights and wears. Past approaches tended to solve thermal elongation of machines using an off line approach, the intention was to identify a machine thermal model that could predict machine elongation. Researchers could realize that the overall precision of part being machined could be increased but the local precision caused by strong hysteresys of thermal cooling down cycles could not be properly modeled by their approaches. While lack of stiffness has been wildly investigated by changes in the design and employ of new materials, the geometrical positioning accuracy of machines mainly depends on the quality of interface components among mechanical structures, the time spent during machine set-up, calibration and tuning. Today MTB try to limit these errors by well done, but expensive in production time interfaces among movable parts; a long and accurate machine installation at the customer place to ensure the correct perpendicular movement of machine axes; the use of measuring and compensating procedure.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Reactive Agent-based Tangible simulation for decision making in urban studies'.

assistant: **Objectives**

Cities have to develop new ways to manage road infrastructures and vehicle flows to improve air quality. In the last decades, in the field of urban planning, many advances have been made, however the urban planning processes are still reliant on very traditional approaches that are very laborious and are highly dependent on intellectual processes. ReAgents focuses on urban modelling, and participatory simulation for future mobility to improve decision making and urban planning strategy in the Metropole de Lyon. The fellowship will be carried out at Unviersité Claude Bernard Lyon 1 (UCBL) under the supervision of Gilles Gesquiere deputy director of a national “Laboratory of Excellence” (LabEx) project entitled IMU (“Intelligence des Mondes Urbains”/ Intelligences of Urban Worlds).  The experienced researcher will model and simulate the impacts of urban policies on traffic and air pollution emissions using agent based-models (ABM). These models will be displayed on a physical 3D model of the city, called tangible user interface (TUI). ABM coupled with TUI represents a radically new decision support tool for the different stakeholders of the Metropole de Lyon which can be used to explore and assess new urban planning strategies that meet citizens and stakeholders needs.The ReAgent project will reinforce the ER’s interdisciplinary research and transferable skills as well as its professional network in both the academic and private sectors since universities, public actors (including the Metropole de Lyon), associations and companies are involved as partners in IMU.


**Keywords:** decision making, computational modelling, agent-based model, tangible interface, smart city
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'POLICY ASSESSMENT OF TRANS-EUROPEAN NETWORKS & COMMON TRANSPORT POLICY' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

1. To provide a preliminary policy assessments methodology related to decisions on transport infrastructure investments and service evaluations; more specifically, the aim is to develop a methodology that could be utilised in the assessment of alternative.2. To provide a comprehensive policy assessment of the European Common Transport Policy (CTP) with a view of advancing forward recommendations that may assist its further development and implementation.3. To provide input and data for further or parallel research on the subject (and specifically with reference to tasks 11, 12, 13, 19 and 20 of the strategic research programme).Links with other projects, tasks, areas, programmes, policy actions:Input and data for further or parallel research on the subject (and specifically with reference to tasks 11, 12, 13, 19 and 20 of the strategic research programme).Case studies6 case studies planned but not yet defined
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'High-speed chip-based nanoscopy to discover real-time sub-cellular dynamics' to be submitted under Seventh Framework.

assistant: **Abstract**

Optical nanoscopy has given a glimpse of the impact it may have on medical care in the future. Slow imaging speed and the complexity of the current nanoscope limits its use for living cells. The imaging speed is limited by the bulk optics that is used in present nanoscopy. In this project, I propose a paradigm-shift in the field of advanced microscopy by developing optical nanoscopy based on a photonic integrated circuit. The project will take advantage of nanotechnology to fabricate an advance waveguide-chip, while fast telecom optical devices will provide switching of light to the chip, enhancing the speed of imaging. This unconventional route will change the field of optical microscopy, as a simple chip-based system can be added to a normal microscope.  In this project, I will build a waveguide-based structured-illumination microscope (W-SIM) to acquire fast images (25 Hz or better) from a living cell with an optical resolution of 50-100 nm. I will use W-SIM to discover the dynamics (opening and closing) of fenestrations (100 nm) present in the membrane of a living liver sinusoidal scavenger endothelial cell. It is believed among the Hepatology community that these fenestrations open and close dynamically, however there is no scientific evidence to support this hypothesis because of the lack of suitable tools. The successful imaging of fenestration kinetics in a live cell during this project will provide new fundamental knowledge and benefit human health with improved diagnoses and drug discovery for liver. Chip-based nanoscopy is a new research field, inherently making this a high-risk project, but the possible gains are also high. The W-SIM will be the first of its kind, which may open a new era of simple, integrated nanoscopy. The proposed multiple-disciplinary pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Chromatin structure and plasticity' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The mammalian genome is packaged into a dynamic structure known as chromatin. There are a range of mechanisms - often referred to as 'epigenetic' controls -that alter its structure and function. These include post-translational modifications, histone variants, and non-coding RNAs. Considerable efforts have been directed at deciphering the epigenetic mechanisms that govern vital biological events such as centromere maintenance, cell-fate determination during development and targeted-recombination. Chromatin pathways are receiving increasing attention as drug targets, since epigenetic components lead to major human diseases such as cancer and heart disease. The complexity of the underlying molecular events, combined with the rapid pace of technological progress and specialization, calls for an integrated effort taking ull advantage of synergistic in vitro, in vivo, clinical and therapeutic approaches. We focus our work on specialized histones, non-coding RNAs and miRNAs. In addition, we analyze how alternative splicing and chromatin-binding metabolites directly influence chromatin structure. This is complemented by novel RNA tools, statistical methods, conceptual breakthroughs, therapeutic targets and patentable lead compounds. We build an innovative and strong training initiative that will expose ESRs to the best-of-practice approaches and scientific interdisciplinarity across academia and industry. Further, we will improve existing standards of training and career development for ERs, which to date has not received as much attention, yet is vital to promote life science and the development of talented and independent researchers. Our multidisciplinary and intersectorial RTN prepares the next generation of European scientists to the highest standards and will reveal nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A new dynamic precision LED-lighting system for hydro- and aquaponic indoor farming' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The overall objective of the flexiLED-project is the successful and sustainable market entry of the dynamic precision lighting solution Malina from Ponix Systems GmbH as a B2B-product for large-scale greenhouses and indoor, urban farms. Therefore, a market strategy based on the highest market potentials as well as the smaller potential markets which are easier to reach has to be developed within a proper feasibility study for an optimised product and described in a detailed strategic business plan and negotiations with first large-scale customers have to be started. Ponix Systems’ Malina addresses first of all greenhouses but also urban-, vertical farms which aim for minimising time, land, water and energy input in agriculture. Malina is capable of irradiating each crop of these farms with precisely the spectral composition which is best for its light induced development (photomorphogenesis) at any given moment from germination until harvest. The plant specific development goal (e.g. time of harvest or of flowering, size, volume and nutritional content) can be chosen by the farmer by simply downloading “Malina light recipes” on to the hardware. By contributing to the LED market diffusion in this segment through novel functionalities, Malina is a truly eco-innovative and resource-efficient food production methodology. Malina furthermore minimises food losses on farms because of detection of unusual changes in plant physiology at any time. This is based on sensors integrated in the lighting solution, the possibility to extend the hardware with exogenous sensors and plant feedback algorithms based on analysing the reflected & emitted light of the plants under changing spectral compositions further allows for detecting unusual changes in plant physiology at any time. Thus a