RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Investigation of structural interactions of Fibronectin type III domains' (FNIII-STRUCTURES), addressing dissemination and exploitation.

assistant: **Impact**

Fibronectin (FN) is a multidomain extracellular matrix protein also present in soluble form in blood and tissue fluids. Soluble dimeric FN assembles on the cell surface into a supermolecular structure known as the FN matrix, which appears during embryonic development and wound healing. The monomeric subunit of FN is composed of three types of repeating domains, named type I, II and III. Recent reports suggest that FN type III domain unfolding is important for regulation of the FN matrix formation, and that it could also be the basis of the FN elasticity. Of particular interest are the first three type III domains (1FNIII, 2FNIII and 3FNIII), which harbour FN self-association sites and have been shown to be necessary in part for fibril formation. Anastellin, a truncated derivative of the 1FNIII domain has also be shown to be capable of inducing formation of an FN matrix-like supermolecular structure. Recent studies in our laboratory have shown that 1FNIII and 2FNIII are connected through a long amino acid linker, thus allowing significant flexibility in the relative orientation of 1FNIII and 2FNIII. In contrast, all other type III domains are connected through small linkers, which restrict the flexibility of relative orientations between adjacent domains. Preliminary results confirm the presence of an interdomain interaction between 1FNIII and 2FNIII. Here we propose to use high resolution NMR techniques to investigate the structural interactions between the first three type III domains of FN. Our aim is to deter mine the mode of association between these domains in various combinations, as well as the resulting three dimensional structures. In addition, the effect of anastellin on the possible interactions between these three domains will be studied. We expect that thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel RF Driven MRI Magnet for Imaging Enhancement' (RF-MAFS), addressing dissemination and exploitation.

assistant: **Impact**

The key goals of the RF-MAFS project are: the training of the Experienced Researcher (ER) Dr. Javier Alonso-Valdesueiro, in the fast growing field of Scientific Instrumentation, where the host and partner institutions have critical knowledge and expertise and the design, development and optimisation of a new Magnetic Resonance Imaging (MRI) machine based on the concept of Radio-Frequency Magic Angle Field Spinning (RF-MAFS). The aim of the  research  project is to design and develop a novel type of portable MRI scanner which enhances the image resolution by applying a rotating magnetic field. This project brings together Engineering Skills, Magnetic Resonance (MR) Knowledge and Medical Imaging Insights. Therefore, it will clearly have a broad positive impact on the European Research Area (ERA). The interdisciplinary and intersectoral training program includes specific training in RF power devices, magnet design  and training in transfer of knowledge from academia to industry. Then, it will enhance and broaden Dr. J. Alonso-Valdesueiro´s expertise in Applied Scientifc Instrumentation, increasing his exposure to both academia and industry. The Fellow is a talented researcher who has gained much expertise in engineering applied to NMR during his postgraduate career. This background is of great value for the optimization magnet design for medical imaging. But for further boost his career, Javier needs to gain expertise in prototype construction for scientific applications in which the University of Basque Country has a world-recognised expertise. Additionally, through the three-month secondment at University College London he will have contact with the medical image processing part of the action. Therefore, The multidisciplinary project  activities including outreach activi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of Rnd proteins in the regulation of dendrite, spine and synapse formation in the developing hippocampus and their implication in hippocampal-dependent memory'.

assistant: **Innovation**

The rapidly growing elderly population and the increasing occurrence of memory disorders make the promotion of “healthy ageing” and the treatment of these disorders a major challenge in our modern societies. However, the development of treatments is hindered mainly because the biological basis of memory is still unclear. For this reason a better understanding of the mechanisms regulating memory processes appears fundamental. Normal development of hippocampal networks is crucial for memory and learning. In particular, the proper development of the dendritic arbor and spines is critical for the establishment and function of synapses, and, in turn, for neuronal activity and brain function.In the project presented here, I propose to study the role of Rnd proteins in the regulation of dendrite, spine and synapse formation in the developing hippocampus and their implication in hippocampal-dependent memory. Indeed, my preliminary data and data from the literature indicate that these atypical RhoGTPases are particularly good candidates to modulate these functions but this has not been explored yet. The ultimate goals of this study are to provide mechanistic insights into the critical aspect of memory regulation and eventually to propose new therapeutic strategies for learning and memory disorders. The attractiveness of this project is to study the role of these Rnd proteins directly in vivo by using not only in vivo electroporation of Rnd shRNA but also Rnd conditional knockouts. To successfully achieve the goals of my proposal, I have chosen to conduct this project in a host laboratory which is well known for its expertise in memory, behavior and adult hippocampal neurogenesis. Thus, the successful funding of this proposal will allow me to complement my current experimental an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhanced mobile phone with application specific memory system' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The main objective of the project is to deliver a full featured 1.8GHz GSM phone incorporating a prototype of the integrated embedded applications specific memory system developed in the project. The prototype phone will be tested with the Nokia standard validation procedure which includes, amongst others, durability testing at high and low temperatures;The application specific memory will be initially manufactured in 0.6 um technology and be shrinkable to 0.5 um.The successful completion of the project will provide the opportunity for SGS-Thomson customers to have developed application specific memories combining customisable quantities of flash and EEPROM function for use in a very broad range of market sectors.The aim of the project is the development of an application specific memory integrating flash and EEPROM functions on the same chip for use, amongst others, in cellular phone applications. This innovative semiconductor device will be developed by the semiconductor company, SGS-Thomson, to the specifications determined by cellular phone manufacturer Nokia who will include the device in a phone demonstrator. Characterisation and process reliability studies will be undertaken at the IMEL research institute.A new non-volatile memory cell concept will be developed in order to integrate both flash and EEPROM memory structures on the same chip without any increase in manufacturing complexity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synthesis of Novel Porphyrazines and seco-Porphyrazines for Medical Diagnostic and Therapeutic Applications' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

It is proposed to examine the synthesis or novel diporphyrazme systems derived from the crossed Instead macrocyclisation reactions of diaminomaleonitrile derivatives with biphenyl-2, 2,3,3-tetranitrile or tetracyanoethylene. The resulting porphyrazines are expected to show red-shifted UV-visspectra with the long wavelength Q bands above 700 nm. In addition, these porphyrazines should be precursor molecules for the preparation of the structurally related seco-porphyrazines. Thesemacrocycles will be assayed as probe molecules for the detection of cancers and as probe molecules in studies of cell differentiation. The seco-porphyrazines should be effective imaging agents and/ortargetable sensitises for singled oxygen generation for the photodynamic therapy of cancer and infectious diseases. The proposed work is relevant for the development of novel diagnostic and therapeutic agents with diverse medical applications. Amongst legions of diseases, one illustration will suffice: breast cancer is the leading cause of death amongst EU and US women in the age range 40-49.Unfortunately, the current technique of annual mammograms is insufficiently reliable with significant levels of false-positives" and the more sinister "false-negatives." Clearly, there is the need for more reliable yet non-invasive imaging methods. Optical imaging of breast tumours with computer image enhancement holds great promise but clearly requires the development of non-toxic agents, which show selective tissue localisation and absorb visible light at long wavelength (> 700 nm) so that the background absorption by haemoglobin is minimised (the optical transparency of soft tissue can be easily shown withal torch and the hand). Thus, the development of effective agents to enhance early detection rates for bre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design for Humanization of Technology' in the context of a Fifth Framework call.

assistant: **Objectives**

The goal of the Project DESIGN FOR THE HUMANIZATION OF TECHNOLOGY is to develop a study/analysis of the concept of office space, no longer interpreting it as an aggregation of separate functions, but as a series of social and productive interrelations", with the objective of providing furniture manufacturers with suggestions for new ways to confront the challenges posed by changes in communications technology. By calling together experts, design centres, universities, technology producers and furniture manufacturers, our discussions will produce concrete examples of how to improve the quality and humanity of the workplace, comparing various solutions to the problems created by new technologies. HUMANTEC is a thematic network, which is open to new members. This project will take place under the direction of an International Scientific Committee and will develop first through local meetings, then over the Internet, and finally in an international convention that will facilitate the widest possible diffusion of the project's goals and results."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Restoration of upper limb function in individuals with high spinal cord injury by multimodal neuroprostheses for interaction in daily activities'.

assistant: **Innovation**

More than half of the persons with spinal cord injuries (SCI) are suffering from impairments of both hands, which results in a tremendous decrease of quality of life (QoL) and represents a major barrier for inclusion in society. Functional restoration is possible with neuroprostheses based on functional electrical stimulation (FES). However, current systems are non-intelligent, non-intuitive open loop systems without sensory feedback.MoreGrasp aims at developing a multi-adaptive, multimodal user interface including brain-computer interfaces (BCIs) for intuitive control of a semi-autonomous motor and sensory grasp neuroprosthesis to support activities of daily living in individuals with SCI. With such a system a bilateral grasp restoration may become reality.The multimodal interfaces will be based on non-invasive BCIs for decoding of movements intentions with gel-less electrodes and wireless amplifiers. The neuroprosthesis will include FES electrode arrays and different sensors to allow for implementation of predefined or autonomously learned sequences. MoreGrasp will consequently follow the concept of the user-centered design by providing a scalable, modular, user-specific neuroprosthesis together with personalized EEG recording technology. Novel multimodal software architectures including interoperability standards will be defined to integrate neuroprostheses into the field of assistive technology.Long-term end user studies will demonstrate the reliability, usefulness and impact on QoL of the MoreGrasp technology. A web-based service infrastructure including a discussion forum will be set up for assessing user priorities and screening of users’ status. The evaluation of the training and patterns of use will allow for user modeling to identify factors for successful use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ARTIFICIAL PHOTOSYNTHESIS for ENERGY PRODUCTION - MANGANESE RUTHENIUM CHEMISTRY BASED on PRINCIPLES FROM THE NATURAL PHOTOSYNTHESIS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The broad competence provides a rich environment for graduate students and photosynthetic energy conversion. In these super complexes, ruthenium is post docs. In the network exchange, our young researchers will learn from many different fields. In the process, our assembled competence will be the photoelectron donor. A new concept is to regenerate, as in natures broadened and deepened with the next generation of researchers. For Photo system II, this donor by electron abstraction from water using a example; Post docs with basic education in synthesis and organometallics manganese complex. The ultimate goal is to couple an antennae, a Ru reaction centre and a Mn complex in a super complex able to oxidise water. will learn photochemistry, fast optical spectroscopy, membrane chemistry and natural photosynthesis. This will generate bridges between fields that The new complexes will be characterised with advanced-EPR and ultra fast are normally isolated. The exchange of post docs also involves less optical spectroscopy. The initial results will be of basic character but favoured regions (Sicily, Napoli, Halle (Germany), Ireland). we aim at production of fuel e.g. hydrogen from water. The network contains groups specialised in organo-metallic synthesis, natural photosynthesis, spectroscopy and membrane chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A novel affordable, portable and autonomous wastewater treatment unit for the agriculture industry' (2014-2020).

assistant: **Innovation**

WasteWater Science Ltd is a Maltese fast growing SME that has a clear business objective to produce wastewater recoveryproducts and to reclaim the nutrients in the wastewater for productive use. Our company intends to commercialise a novelaffordable, portable and autonomous wastewater treatments units and make the business more profitable and sustainablethrough a novel business model. We are challenging the status quo of organic waste disposal by offering producers a noveland greener alternative that is more convenient, eliminates disposal and hauling costs and in countries where water is ascarce and expensive resource it recovers water from organic waste, thus reducing significantly their water bills. 70% of theworld’s water is used in the agricultural sector. Our novel product creates added value from waste and by-productsgenerated on farm and saves the farmer 85% of costs. Our company has diversified from Big Players and has created anuntapped niche market in the $1 Billion wastewater treatment industry. Our solution provides a high economic impact to theglobal agriculture sector. We foresee that our innovative product will generate over €5 Million to our annual revenue by 2020,increase our annual profits by 10% and grow direct employment by 1150% by 2020. Phase 1 of this innovative project is tocarry out an elaborate Feasibility Study and Business Plan to get this product from TRL6 to TRL9 and commercialise it in theinternational market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dinuclear Gold Catalysis: A New Platform for Cross-Coupling Reactions' (TWINGOLD) under Horizon 2020.

assistant: **Objectives**

Gold catalysis has become a powerful tool for organic chemists to streamline synthesis of valuable and complex molecules. Compared to other transition metals, gold complexes are remarkably stable towards air and water, and are essentially non-toxic, which make them ideal candidates to execute catalytic cross-coupling reactions in industry or in vivo. TWINGOLD aims at broadening the current applications of gold catalysis, exploring and identifying reliable dinuclear gold(I) catalysts in C-C forming reactions. The use of dinuclear gold catalysts could lower activation barriers of chemical transformations and thus allow access to reaction pathways that are difficult to accomplish with mononuclear gold systems. TWINGOLD will promote gold catalysis significantly by exploring novel cross-coupling reactions and the related mechanistic elements behind them, enabling use of more diverse raw materials and, thus, ensuring a more sustainable and inclusive economy in EU. In addition, the project will enable the Experienced Researcher to develop a full range of scientific and transferable skills following a personalized Career Development Plan to become an established researcher (R3).


**Keywords:** dinuclear gold, cross-coupling, catalysis, alkylation, reaction mechanism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Restructuring large-scale housing estates in european cities : good practices and new visions for sustainable neighbourhoods and cities' (RESTATE).

assistant: **Concept**

The subject of the proposal is the quality of life in the large-scale housing estates built since the end of WWII in cities of Eastern and Western Europe. Many of these estates will be the urban problem areas of the near future, housing large numbers of low-income households, unemployed people and those from ethnic minorities. The proposal is concerned with policies developed in response to problems in these estates and with key aspects of the estates (such as social inclusion, cohesion and sustainability). The study involves strong collaboration with stakeholders and end-users. The focus will be on evaluating, understanding and learning from the experience in different cities in order to facilitate the improvement of policies and actions. The provision of evidence based 'good practice' guidance, new visions and forward-looking scenarios will contribute to more effective policymaking and will benefit European cities.