RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexibly Scalable Energy Efficient Networking' under Horizon Europe.

assistant: **Concept**

FLEX-SCALE advances disruptive research on complementary optical x-haul network technologies for Optical Switching Nodes and their Transceiver Interfaces that enable flexible capacity scaling (≥10 Tb/s rate per interface, ≥1 Pb/s capacity per link and ≥10 Pb/s throughput per optical node) based on utilization of ultra-high bandwidth photonic/plasmonic technologies and the efficient exploitation of optical spatial and spectral switching (UltraWide-Band Spectral & Spatial Lanes Multiplexing; UWB/SDM). The developed x-haul 6G optical network innovations will achieve record energy efficiency (sub-pJ per switched/transmitted bit ) and low cost, enabled by photonic integration and optical transparency, replacing/bypassing power-hungry and costly electronic processing systems (e.g., electronic routers/switches). The Optical Nodes and their Transceiver Interfaces will be controlled by ML-enabled SDN control plane approaches that incorporate new resource allocation algorithms and protocols relying on emerging information models and enabling autonomous programmable disaggregated open networks, which will optimize traffic flow routing across network layers and segments, improving network QoS (high rates, low latency, high reliability/availability) and low cost/power consumption, as required by 6G specifications.FLEX-SCALE consortium spans the value chain of industry/academia experts on the targeted topics (transformational transceivers and optical switches, network planning, operation algorithms and protocols development) with demonstrated experience on delivering on their promises, as indicated by their research output and exploitation towards new products, services and standards contributions. FLEX-SCALE is poised to extend Europe’s leadership in 6G x-haul with offerings of high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Activation of polymer surfaces for the production of metal coated composites' to be submitted under Fourth Framework.

assistant: **Abstract**

The project addresses an urgent need for the development of new technology to manufacture metalcoated polymer composite materials for use in decorative (e.g. building, automobile and aircraft industries) and electronics applications (e.g. computers, mobile communications). The project aims to develop technology for the activation of polymer surfaces based upon electrochemically generated etchants to: . Provide new opportunities for increasing the range of industrial applications by achieving greater control of the surface chemistry and producing new polymer surface finishing effects . Replace current hazardous technology, based upon toxic chromic acid, which is limiting new developments within the Proposers' Group In the new proposed approach, the active reagents are continuously regenerated in the etchant solution. The consumption of expensive chemical reagents is very substantially reduced with an equivalent marked decrease in the quantity of waste. The concentration of the active species can be precisely controlled with accurate regulation of the surface oxidation to avoid over treatment and produce definite surface effects. The project is structured to progress from small laboratory scale studies to test-bed operation under industrial conditions using an integrated prototype system. As a result of the potential versatility of this new approach, a greatly increased range of polymers would be amenable to treatment. The majority of the Proposers are currently active in coating polymers with metals using the existing hazardous methods and are urgently seeking new, cleaner technology to provide the opportunity to expand their production activities. A brief feasibility study has been carried out which has successfully demonstrated the considerable potential of this new ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transposon-based, targeted ex vivo gene therapy to treat age-related macular degeneration (AMD)' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Age-related Macular Degeneration (AMD), a neurodegenerative disease of the retina, is a major cause of blindness in elderly people. Due to the aging population, AMD has been referred to as a “time bomb” in society. In the exudative form of AMD, high levels of vascular endothelial cell growth factor (VEGF) and low levels of pigment-epithelial derived factor (PEDF), an inhibitor of vascularization and a neuroprotective factor produced by retinal pigment epithelial (RPE) cells result in subretinal neovascularization and retinal pigment cell degeneration. The current treatment by monthly injections of anti-VEGF antibodies is only effective for ~30% of patients. To avoid the severe side effects, high costs and the overall continuing burden on health care associated with monthly antibody injections, inducing a higher level of PEDF expression to inhibit neovascularization would be a viable therapeutic alternative. TargetAMD will subretinally transplant genetically modified, patient-derived, Iris Pigment Epithelial cells that overexpress PEDF to provide a long-lasting cure of AMD. Stable PEDF gene delivery will be based on the non-viral Sleeping Beauty transposon system, which combines the efficacy of viral delivery with the safety of naked DNA plasmids. Academic scientists and SME partners will produce innovative gene delivery technologies, reagents and devices to be translated into a simple and safe gene therapeutic treatment for exudative AMD. Experienced clinicians will perform one clinical trial, comprising isolation and PEDF-transfection of a patient’s pigment epithelial cells and implantation of transfected cells into the patient during a single, 60-minute surgical session. This project will bring a significant enhancement on quality of life to AMD patients, highlight th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spinning Disc Reaction Technology for Cost- and Resource Effective Chemicals Production' (SPINOVATIVE).

assistant: **Innovation**

Cost and resource effectiveness of pharmaceuticals and fine chemicals production rely largely on the level of process control. However, the chemical industry is currently not able to grasp full control over the chemical reactions in these segments where batch reactors dominate, resulting in high production costs and a serious environmental burden due to the use of excessive amounts of raw material and significant downstream waste streams. There is thus a strong need for novel tools that allow for fine-tuned reaction conditions in chemical production. Micro management of pharmaceutical and fine chemical production can potentially lead to elevated profit margins and environment-friendlier operations. A company that can enable this shift will therefore be able to work with leading chemical firms and to win a strong market position. It is exactly this challenge that we face by translating our ERC research results towards a business proposition for the chemical industry.The ERC funded work of Prof. Schouten et al. has led to the development of a novel reactor type that facilitates optimal production conditions for a broad range of chemicals. The innovative power is advocated by research results that clearly show that the device creates the opportunity to downsize industrial separators and reactors by a factor of 10 to 100; that the reaction time is reduced up to 99%; that impurity levels are hugely lowered and that downstream purification results in much smaller waste streams. The patented technology thus addresses all the main issues related to batch reactors and forms a sound platform for commercialisation. The ERC Proof of Concept study will allow us to assess the options for marketing and to set up a concrete business plan for a spin-off company.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stretchable Piezoelectric Nanogenerators for Energy Harvesting in Elastic Environments' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Nanoscale piezoelectric (PZ) energy harvesters, or nanogenerators (NGs), are vital for next-generation autonomous devices as they can directly convert small-scale vibrations, such as blood flow and body movements, into electrical energy. Scavenging power from ubiquitous vibrations in this way offers an attractive route to supersede fixed power sources such as batteries that need constant replacing/recharging. In particular, epidermal or implantable PZ NGs could revolutionize wearable electronics and healthcare monitoring. The associated elastic environments require not only flexibility of the NG, but also stretchability in order for it to remain operational. Current NGs are rarely functional without being coupled to rigid or, at best, flexible substrates, due to the lack of proper methodology for fabrication of both stretchable electrodes as well as stretchable high performance PZ nanomaterials, that together make up PZ NGs. Thus, the Action aims to (i) develop micro/nano-patterned electrode fabrication techniques based on electronic printing on flexible/stretchable substrates, (ii) develop polymer-based PZ materials with tailored elastic properties to satisfy stretchability and flexibility criteria, marking a departure from traditional PZ materials that are ceramic in nature and hence stiff and brittle, and (iii) study the efficiency of the stretchable NGs developed, based on simulations and direct measurements of energy harvesting (EH) performance in elastic environments. The Action will address pressing EH challenges such as scalability and cost of fabrication of stretchable NGs, and enhancement of energy conversion efficiency over a wide range of deformation scenarios, with an aim to broaden the application of NGs to EH in biological and other extreme environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transcriptional RegulAtory Network controlling Strawberry Fruit Ripening and Quality' (TRANSFR-Q), addressing dissemination and exploitation.

assistant: **Impact**

Ripening is the critical step for the development of flavour quality in fruit. This character has significantly declined in many fleshy fruits over recent decades, primarily due to the focus of current breeding programs on agronomic traits such as production, firmness, and postharvest shelf life. This strategy has caused a tunnelling effect on genetic variability in many crops. This is particularly significant in strawberry, where current cultivars are derived from a narrow germplasm stock. A notable feature of strawberry fruit is that undergoes a non-climacteric ripening program independent of the hormone ethylene, in contrast to well studied climacteric fruits such as tomato, where ethylene plays a central role. Therefore, improving fruit flavour in present strawberry varieties requires two important breakthroughs: 1) a precise understanding of non-climacteric fruit ripening regulation that will allow the targeting of relevant quality genes, and 2) the identification of unexploited allelic variants from wild germplasm to be introgressed through the generation of novel breeding lines. The first objective will be achieved by (i) focusing on the sequenced, diploid Fragaria vesca, a wild relative of the cultivated strawberry that will serve as a model, (ii) identifying key transcription factors (TFs) regulating fruit ripening by generating a stage- and tissue-specific gene expression map, (iii) using a candidate gene approach and reverse genetics based on gene silencing and TILLING to verify the role of these TFs, and (iv) defining the gene regulatory networks controlling the ripening process via integration of transcriptomic, metabolomic and ChIP-Seq data obtained from the stably silenced and/or TILLED lines. Finally, TRANSFR-Q plans to use this knowledge, combined with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Autonomous Drones for Nature Conservation Missions' in the context of a Horizon Europe call.

assistant: **Objectives**

The aim of WildDrone is to push wildlife conservation practices into the 21st century. The need for effective, cost-efficient conservation practices are greater than ever as we currently face the greatest loss of global biodiversity in history. Present conservation practices are typically very labour intensive, costly, and time-consuming. Collected data is often inaccurate or incomplete. However, recent advances in drone technology have shown that this technology has great potential as a practical tool for conservationists and that it could potentially revolutionize our efforts in nature conservation. Nevertheless, drone technology is still a developing field and many obstacles stand in the way of us harvesting the benefits of this emerging technology. To fully achieve its promising potential in this new domain we will need to invent more robust and predictable robotic technologies, including effectiveand automated means of gathering and interpreting ecological and behavioural data. WildDrone will address these challenges by joining the scientific areas of aerial robotics, computer vision, and wildlife ecology. The network proposes to develop new autonomous drone technology, expand current computer vision capabilities, and combine these advances to create practical tools for visual inspection and monitoring of wildlife populations. This drone-based inspection will provide conservationists with crucial knowledge of animal health, behaviour, and numbers. These challenges will be solved by 13 PhDs (three self-funded). An interdisciplinary research training programme has been designed to educate a new generation of PhDs and provide them with a unique skill set enabling them to tackle the great challenges we must solve collectively, if we are to reverse the decline of global
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Biochemical characterization of mhc class ii restricted human minor histocompatibility antigens'.

assistant: **Objectives**

Minor Histocompatibility antigens (mHag) are responsible for the development of Graft- versus-Host-Disease (GVHD). They induce strong MHC restricted cytotoxic (CTL) and proliferative (Th) T cell responses which can be measured in vitro. In addition to CTLs, mHag Th cells play a role in the pathogenesis of acute GVHD. I will therefore aim at elucidating the nature of the MHC class II-restricted human mHag peptides and the proteins from which they originate. By immuno and biochemical isolation and purification procedures combined with sensitization of stimulator cells for T cell recognition, mHag peptide containing fractions responsible for stimulator cell sensitization will be identified. Subsequent mass spectrometric analysis will determine the amino acid sequence. Synthetic peptides generated accordingly should confirm the natural peptide sequence. Naturally, determination of the nature of MHC class II restricted mHag is clearly important in understanding the basis of the T cell responses these antigens evoke in transplantation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'High performance materials derived from industrial-waste gypsum'.

assistant: **Concept**

Foreseen ResultsThe proposed project will develop new technology of high performance materials which offers the potential of large scale utilisation of synthetic gypsum and provides an economic alternative to the use of more expensive binders such as hydraulic cements and lime. Two categories of materials will be developed on the basis of novel concepts as outlined below:Blended binders will be developed from industrial waste products such as gypsum, fly ash and slag for the manufacture of a range of materials. The pozzolanic reaction of the binders will be activated by chemical admixtures. These blended systems will be used to develop new materials for mining, road making, insulating / structural and ecological applications. Lightweight aggregates will also be developed.Self - binding reactions within the gypsum matrix will be generated by chemical activators to produce ceramic like materials at ambient temperature (or slightly elevated temperature), but without firing. A process to alter the hygroscopic nature of gypsum will also be developed. The project will develop non-hygroscopic, high density panels for structural applications and low density panels for acoustic applications.A comprehensive classification of physical, chemical and mineralogical characteristics of waste gypsum in Eastern Europe will be carried out and a computer data base established.The phase composition and reactivity of gypsum produced by the dry and semi-dry desulphurisation process will be determined. A socio-economic plan will be developed for the economic exploitation of the research.Present and future plans of the power industry in many countries of Europe (East and West), such as Poland and Slovakia, indicate that in the next 100 to 200 years, the predominant raw materials used in the pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Contribution to the elimination of measles from East Africa' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

* Implementation of rapid, simple and cheap diagnostic tests for measles that can be used under field conditions.* Establishment of a diagnostic virological lab, operating according to WHO standards. This lab may participate in WHO eradication efforts for measles in the near future.* Evaluation of the epidemiology of measles in the Sudan, including vaccine coverage and efficacy.* Insight in the overall health impact of measles in the Sudan, including estimation of case-fatality ratios.* Evaluation of naturally acquired and vaccine-induced measles virus-specific antibody and T-cell mediated immunity.* Knowledge about the mechanisms of measles-induced immunosuppression.Expected Outcome* Technology transfer from WHO reference labs to the Sudan, including the building of an infrastructure and training of personnel, which will be essential in the planned WHO global eradication program for measles.* Knowledge about epidemiology and health impact of measles in the Sudan.Field work* Establishment and follow-up of a cohort for the measurement of maternal antibodies, the estimation of the true incidence of measles and the performance of the new diagnostic field test.* Establishment of a cohort of acute measles cases for immunological and virological studies.Lab workAfter training in Rotterdam and Lyon, immunological and virological studies will be continued in the Institute of Endemic Diseases in Khartoum, in which a new virology lab will be established.TrainingA MD student (epidemiological work, diagnostic test and a PhD student (immunological and virological studies) from the Sudan will be trained in this project.