RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'E-INFRASTRUCTURE MONITORING, EVALUATION AND TRACKING SUPPORT SYSTEM', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

While Africa is the fastest growing region for e-infrastructure development, the lack of accurate knowledge on past and ongoing e-infrastructure projects on the ground creates many uncertainties in international cooperation. Additionally, the lack of coordination among international development agencies is generally viewed as a major detriment to the effectiveness of their action. In their policy recommendations, prominent reports have emphasized the need to establish appropriate tools to enhance the coordination of e-infrastructure development policies and to reinforce the collaboration of the different stakeholder groups for the firm foundation for expanded education and research networking throughout the region.<br/>The iMentors project aims to enhance the effectiveness and coherence of national and EU research policies and the international cooperation in the field of research infrastructures. In close consultation with the stakeholder community, the project will build a virtual observatory, equipped with an advanced Geographic Information System, and a robust decision-support system to position itself as the one-stop-shop data warehouse to retrieve up-to-date information on all e-infrastructure development projects of the past 5 years in Sub-Saharan Africa. In doing so, iMentors aims to create an online community for support to policy development and programme implementation, and launch a dedicated space for online collaboration, facilitating interaction and knowledge sharing, in order to offer to stakeholders the opportunity to create synergies and plan future projects. The entire dynamic of the project is centered on positioning iMentors as the knowledge broker in this policy area, an objective which requires building and maintaining a strong stakeholder ecosyste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chemical Approaches to Restoring Vision' (CARV).

assistant: **Concept**

Blindness affects millions of people worldwide and has devastating consequences for those affected. It is often caused by a loss of photoreceptors in the retina, whose residual cellular network remains largely unaffected. Various strategies have been chosen to restore vision, such as electrical stimulation with retinal implants. More recently, natural photoreceptor proteins and stem cells have been explored. We propose a radically different ¿photopharmacological¿ approach toward vision restoration that is based on synthetic photoswitches. These are combined in various ways with natural receptor proteins to create hybrid photoreceptors, which can then sensitize neurons toward light. In a way we are ¿teaching old receptors new tricks¿ and let them carry out functions that they have not evolved for in Nature. Our hybrid photoreceptors and photochromic drugs work well in experimental animals and have already been shown to influence their visual behavior. To make these molecules work in humans, we need to improve their photophysical properties and investigate their delivery, stability and pharmacology. This requires an extensive program in synthetic chemistry, which should be accompanied by effective and immediate neurobiological evaluation. Our very general approach to optically controlling neural activity can be applied to other functions and malfunctions of the nervous system, such as pain or epilepsy, but its greatest medical potential currently lies in the restoration of vision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Phase Ia/b study of MEK1/2 inhibitor PD-0325901 or MEK-162 with cMET inhibitor PF-02341066 in RASMT and RASWT (with aberrant c-MET) Colorectal Cancer Patients.' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ineffective treatments. Increased understanding of cancer biology, coupled with the implementation of “omics”-based approaches, has revealed that cancer must be considered a heterogeneous disease. Historically, “one-size-fits-all” approaches have been standard practice in CRC treatment, but with the increased understanding of the molecular/genetic heterogeneity of CRC, it is clear that novel treatments must be developed and tested in selected subgroups to maximize the benefit of these new developments. MErCuRIC is a multicentre phase Ia/b clinical trial which will assess a novel therapeutic strategy (combined treatment of a MEK inhibitor PD-0325901 or MEK-162 with a MET inhibitor PF-02341066) to combat metastasis, improve survival and change current clinical practice for CRC patients with RAS mutant (MT) and RAS wild type (WT) (with aberrant c-MET) tumours. The consortium will go beyond the current state-of-the-art by (i) employing a novel treatment strategy targeting the biology of the disease and by (ii) using next generation sequencing (NGS) and ‘xenopatients’ to identify CRC patient subgroups who will maximally benefit from this novel treatment strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transcriptional regulation by bhlh-pas proteins; a novel family of transcription factors', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Regulation of gene expression under hypoxic conditions is an important feature of many medically very relevant processes. The hypoxia-inducible factor HIF-la mediates transcriptional responses to hypoxia by dimerizing with the transcription factor Arnt. Both HIF-la and Arnt are members of a novel subclass, bHLH-PAS, of the basic helix-loophelix (bHLH) family of transcription factors. Regulation of gene expression by HIF-1 will be examined in detail at two critical steps in the signal transduction cascade: ? Mechanism of conditional regulation of HIF-1, i.e. mechanism of repression and derepression. ? Identification and characterization of co-factors that mediate (or repress) transcriptional activation by HIF-1. Are these factors similar to or distinct from coactivators of members of the steroid hormone receptor superfamily? Is the functional communication with these factors by HIF- 1 regulated by hypoxia? More specifically, the domain of HIF mediating hypoxia responsiveness will be identified, and it will be examined if this domain represents a novel ligand binding domain for an as yet unknown class of compounds. Moreover, to understand the mechanism of HIF-1 signaling we will examine if HIF- 1, a putative orphan receptor, recruits a similar battery of transcrptional co-activators as steroid hormone receptors, and whether the already indentified factors, are, in fact, also facilitating transcriptional activation by conditionally regulated bHLH-PAS factors. If this is not the case, novel co-activators will be identified in parallel two-hybrid screens in yeast. The present program aims to investigate the molecular mechanism of conditional regulation of the HIF- I, a potential orphan receptor. These studies will be important for our understanding of the phyisological funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Virtual Coaching Activities for Rehabilitation in Elderly' (2014-2020).

assistant: **Concept**

One out of six people in the European Union has a disability, usually caused by an acute episode or a chronic disease. Providing a suitable rehabilitation is the main issue for people as they age as it helps people to live independently and enhance their Quality of Life. However, as the rehabilitation period usually last some months, the continuity of care often is interrupted in the transition from the hospital to the home. Virtual Coaches can help these patients to proceed with a personalized rehabilitation that complies to age-related conditions, as the key technology for empowering patients through the enhancement of the adherence to the care plan and the risk prevention. The project “vCare” (Virtual Coaching Activities for Rehabilitation in Elderly) addresses two major shortcomings of the status quo: a participatory design driven by users’ needs and the personalization of the care pathways enabled by technology. In fact that rehabilitation is an ideal setting as “users” (physicians and patients) interact together for a “long” period into the clinic (from two weeks to two months): this is a good opportunity to embed into the knowledge of the system the clinical profiles and the pathways that will drive the behaviour of the virtual coach at home. Well-elaborated services for tele-rehabilitation of former EU projects, such as eWall or Miracolus Life, will be adapted. Therefore, the system will integrate a semantic layer (universAAL) including a reasoning engine that merges all patient-related and context information together. The advanced services of vCare will be deployed on a reference platform of MYSPHERA (FIWARE-based) and implemented in four reference sites, dealing with commonly impacted domains (neurological and cardiological). The results of vCare shall stimul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Object oriented and automated design and management of tools and manufacturing components'.

assistant: **Objectives**

Tooling design and manufacturing processes in the mechanical domain (large series) is very wide and complex. Today CAx systems don't provide throughout processing. It is missing consistent (object oriented) management of information, e.g. geometric, non geometric information, NC data, shop floor information. Form features, parametrics, interactive programming and dynamic linking are needed to complement the use of CAx systems. For some tools, form and information features can be defined as standards to avoid duplication of effort. This object oriented approach is not limited to tools to produce parts, but can also be applied to tools to assemble parts (e.g. welding guns) or any kind of reusable objects. From the information management point of view, even more complex manufacturing components like robots and NC machine-tools can be described using the same methods.The objective of ODEM is to define an infrastructure for an object-oriented information management system. This includes the management of geometry, attributes, non-geometric information, process data and engineering knowledge in the field of design and manufacturing. This will further include the automated generation of bills of material, process work planning and manufacturing information and the standardisation of design methods for stamping tools. Standardisation should permit increased availability & applicability of information management systems for objects providing real benefits.This project will use and refine the data model created as part of the ITRM. The results are specifications and demonstrators. Definition of the detailed functionality of the demonstrators will respect the integration platform specifications within the ITRM.All partners of the consortium are convinced that this new approach to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Solar Boarding House', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Cont. 9. The presentation of results in a form that is meaningful and useful for further work in the field. 10. Determine the market for the PV/T panel and the energy system and preparate a plan for commercial exploitation. 11. Build on and contribute to EU research and development work already undertaken.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Kidney Injury Technology' (KIT).

assistant: **Innovation**

Bio-inRen has developed and patented a revolutionary biomarker-based diagnostic system for a highly and increasingly incident (>10% yearly) and dismally deadly disease (Acute Renal Failure -AKI) posing a huge global health and economic problem worldwide. Bio-inRen’s diagnostic system is envisioned to 1) change the concept and approach to AKI clinical handling, 2) become a reference diagnostic, 3) reduce AKI incidence (by 2.5-5% initially) and improve patient prognosis, and 4) reduce the elevated cost associated to AKI (1% of their global health expenditure, which will be reduced initially in 650 M € in this 1.35 billion people population). An ELISA-based, clinically useful prototype kit has been developed for measurement of human samples. Clinical validation has started, although Bio-inRen’s system needs thorough clinical validation to acquire technological maturity and transferability, for which Phase I and II SME instrument are necessary, on which all the company’s resources will be laid. As a new concept, Bio-inRen’s technology has no competitors in the market or under development. The In Vitro Diagnostic Market grows at a 7% annual rate and will reach $69.1 billion by 2017. AKI-specific market is estimated at 3.5 M cases and 70 M diagnostic tests of the existing gold standard marker. Because Diagnostics is a global and regulated market, Bio-inRen will license the system to large companies and SMEs in the IVD market with manufacturing capacity and international commercialization channels. Technology transfer is expected by 2018 to yield 1 M € upfront and 5% royalties on sales thereafter. 5% market penetration is sought by 2023. As of today, 5% of 70 M tests poses 3.5 M tests as Bio-inRen’s market (6.4 M tests by 2023 at 7% annual growth rate). At a unitary sale price
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Efficient design incorporating fundamental improvements for control and integrated optimisation' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The present energy use of European Buildings is higher than it could be, given the recent developments in control techniques. Optimisation and integration of building control strategies could save huge amounts of energy at European scale, while preserving or improving on present standards of comfort. The EDIFICIO research project proposed here, has the goal to develop innovative, adaptive, integrated control systems to improve the overall performance of the energy management systems and the indoor comfort in buildings. This is achieved by using Soft Computing Techniques (SCT), specially Fuzzy Logic (FL), Artificial Neural Networks (ANNs) and Genetic Algorithms (GAs). Being the result of recent developments in computer science these techniques, already adopted in other industrial processes, are widely recognised to open new possibilities for the solution of integrated complex and adaptive control problems, such as are encountered in the building energy sector. They enable to carry out multi-functional actions directed to integrate energy plants with envelope components and human presence by means of reliable and low-cost control components. The main problem addressed is integrated smart control of the different building functions: - lighting (artificial and natural); - heating and cooling; - indoor air quality and ventilation. In the proposed project new integrated and adaptive control strategies for these building functions, based on SCT techniques, will be developed, integrated and tested, also in real building with real installation. The expected benefits from these strategies will be demonstrated and quantified in terms of: - larger energy saving, by increasing efficiency of BEMS. - higher indoor comfort, by combining the control actions with the humanpresence. The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Machine Vision in Everyday Life: Playful Interactions with Visual Technologies in Digital Art, Games, Narratives and Social Media' (2014-2020).

assistant: **Innovation**

In the last decade, machine vision has become part of the everyday life of ordinary people. Smartphones have advanced image manipulation capabilities, social media use image recognition algorithms to sort and filter visual content, and games, narratives and art increasingly represent and use machine vision techniques such as facial recognition algorithms, eye-tracking and virtual reality. The ubiquity of machine vision in ordinary peoples’ lives marks a qualitative shift where once theoretical questions are now immediately relevant to the lived experience of ordinary people.MACHINE VISION will develop a theory of how everyday machine vision affects the way ordinary people understand themselves and their world through 1) analyses of digital art, games and narratives that use machine vision as theme or interface, and 2) ethnographic studies of users of consumer-grade machine vision apps in social media and personal communication. Three main research questions address 1) new kinds of agency and subjectivity; 2) visual data as malleable; 3) values and biases. MACHINE VISION fills a research gap on the cultural, aesthetic and ethical effects of machine vision. Current research on machine vision is skewed, with extensive computer science research and rapid development and adaptation of new technologies. Cultural research primarily focuses on systemic issues (e.g. surveillance) and professional use (e.g. scientific imaging). Aesthetic theories (e.g. in cinema theory) are valuable but mostly address 20th century technologies. Analyses of current technologies are fragmented and lack a cohesive theory or model. MACHINE VISION challenges existing research and develops new empirical analyses and a cohesive theory of everyday machine vision. This project is a needed leap in visual a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metabolomic analysis for the forensic detection of drugs of abuse in performance and food producing animals' (MET-A-FOR).

assistant: **Concept**

Forensic detection of the illicit use of drugs in performance and food-producing animals is experiencing critical shifts in paradigms with a growing threat in the form of new compounds emerging from human drug development and clinical applications. The MET-A-FOR project will be the first European training platform solely focussed on the development and practical advancement of animal forensic testing based on new concepts in metabolomics. This EID programme will train 3 early stage researchers (ESRs) to be creative, problem-solving and entrepreneurial European scientists with skills in high level interdisciplinary and intersectoral analytical techniques who can aid the translation of emerging discoveries from the academic sector to the commercial sector. The MET-A-FOR project will through the training and development of ESR Fellows and their completion of defined interconnecting PhD projects, bridge the knowledge gaps surrounding the novel concept of metabolomic profiling evident between fundamental researchers in academia (QUB) who have been developing such methods, and non-academic commercial end-users (IDLS) who recognise the necessity and opportunity to apply these methods as diagnostic services. The training of researchers who can utilise these novel innovative analytical tools to increase analysis speeds and sample screening throughput will be essential for providing continuing confidence in monitoring controls and regulations and maintaining animal welfare standards within Europe. ESR Fellows graduating from the MET-A-FOR programme will be uniquely situated to lead, innovate, and collaborate on future technological innovation in the field of analytical monitoring and forensic testing of performance and food producing animals as the challenges in this area increas