RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Concerted action for the setting up of an european veterinary network on diagnosis ; epidemiology and research of mycobacterial diseases' under Fourth Framework.

assistant: **Concept**

Mycohacterial disesases, mainly tuberculosis and paratuberculosis (Johne's disease) are not only a threat to Public Health, but also the cause of of massive financial losses due to condemnations and drop of the productions. Today, tuberculosis and Johne's disease can be a barrier to trade. The present concerted action is based on the will of the partners to share their technology and expertise in order to obtain a common knowledge on mycobacterial diseases that would help to eradicate tuberculosis and paratuberculosis from the countries of the European Union.  Our objetives are: 1. To coordinate the information about the problems encountered in the course of the ongoing eradication programs. 2. Clarify existing or potential reservoirs of mycobacterial diseases among farm and wild animals, and how infection spread between them. 3. Eradication of the diseases in existing reservoirs, as they represent a potential menace for Public Health. 4. To exchange between partner practical knowledge of tuberculosis and paratuberculosis outbreaks, and how is depending on farming and trade practices. 5. To perform epidemiological investigations and tracing of such outbreaks across no longer exinting borders. 6. Clarify quality of available data, and develop standardised collection of epidemiological data in cooperation with the Zoonosis Centers. 7. Set up a databank on strain typing that will be mantained in each laboratory and that will he available for all scientific community. 8. Collection of a representative number of data and strains that will he accesible to others partners for future cooperation research. The exchanges will follow strict guidelines. 9. Exchange of expertise and scientific information, to avoid duplication of reseach and the unuseful competition between groups o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Modelling Text as a Living Object in Cross-Document Context'.

assistant: **Innovation**

Interpreting text in the context of other texts is very hard: it requires understanding the fine-grained semantic relationships between documents called intertextual relationships. This is critical in many areas of human activity, including research, business, journalism, and others. However, finding and interpreting intertextual relationships and tracing information throughout heterogeneous sources remains a tedious manual task. Natural language processing (NLP) fails to adequately support it: mainstream NLP considers texts as static, isolated entities, and existing approaches to cross-document understanding focus on narrow use cases and lack a common, theoretical foundation. Data is scarce and difficult to create, and the field lacks a principled framework for modelling intertextuality.InterText breaks new ground by proposing the first general framework for studying intertextuality in NLP. We instantiate our framework in three intertextuality types: inline commentary, implicit linking, and semantic versioning. We produce new datasets and generalizable models for each of them. Rather than treating text as a sequence of words, we introduce a new data model that naturally reflects document structure and cross-document relationships. We use this data model to create novel, intertextuality-aware neural representations of text. While prior work ignores similarities between different types of intertextuality, we target their synergies. Thus, we offer solutions that scale to a wide range of tasks and across domains. To enable modular and efficient transfer learning, we propose new document-level adapter-based architectures. We investigate integrative properties of our framework in two case studies: academic peer review and conspiracy theory debunking. InterText creates a soli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developmental Impact of MLL-AF4 Fusion Gene linked to Infant Acute Lymphoblastic Leukaemia on Human Stem Cell Fate' (LEUKAEMOGENESIS) under Seventh Framework.

assistant: **Objectives**

The MLL gene is located in chromosome 11q23 and is implicated in >40 different chromosomal translocations, generating distinct leukaemic fusion genes. Unlike other MLL fusion proteins, t(4;11) MLL-AF4 is always found in infant pro-B-ALL with a dismal prognosis in infants and adults. In infant ALL where t(4;11) MLL-AF4 is very common (>80%), the gene fusion arises in utero. However, very little is known about the nature of the target cell for transformation in the embryo/foetus and the mechanisms accounting for its B-cell lineage affiliation. Haematopoietic stem (HSC) and progenitor (HPC) cells represent likely targets for transformation. However, mouse models and transformed cell lines have been used with only modest success to model the effects of MLL-AF4 and the disease phenotypes achieved do not faithfully mimic those seen in the actual infant disease. Moreover, MLL-AF4 protein seems toxic when retrovirally over-expressed in mouse or human stem cells. Here, we propose to explore the developmental impact of MLL-AF4 on human haematopoietic stem cell fate through consideration of distinct ontogeny (embryonic and cord blood-CB-) and hierarchical (HSCs and HPCs) stages of development. Based on state-of-the-art lentiviral and TAT-protein transduction technology, MLL-AF4 will be delivered into human cells in distinct ontogenic and hierarchical positions including: hESCs, CB-HSC and CB-HPCs. The potential transformation effects of MLL-AF4 will be assayed in vitro and in vivo by its ability to disrupt the balance between self-renewal and differentiation. These novel studies will provide insights into the developmental impact of MLL-AF4 on human stem cell transformation and fate, improving our understanding of the molecular pathogenesis and aetiology of this leukaemia. Finally
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sediment Transport Modelling in Marine Coastal Environments' (SEDMOC) under Fourth Framework.

assistant: **Objectives**

The quantification of sand transport rates in the marine coastal environment is a key element in the prediction of sea bed changes, coastline evolution and the morphological impact of human interference, such as beach nourishment and other coastal protection schemes. Large gaps still remain in our present knowledge of sediment transport processes, and a continuing need exists for an improvement in our understanding leading ultimately to reliable, well-validated, practical modelling systems. The main objectives of the project are therefore: - To increase knowledge of the physical processes involved in the transport of non-cohesive sediment (sand) under the influence of waves and currents; - To develop improved predictive mathematical models for the quantitative description of sediment transport processes; and - To deliver simplified sand transport models for use in coastal engineering practice. The research will be concentrated on three main topics: A. Near-bed sediment transport processes; B. Suspended load processes; and C. Engineering sand transport formulations. Topics A and B will be concerned with sediment transport by waves and currents in both the sheet flow and rippled bed regimes, including the effects of sediment size gradation, of bed slope, and of various fluid-sediment-bedform interactions. These topics will be studied through a combination of innovative experimental work in the laboratory and mathematical model development. Topic C will involve the application of the results of these sophisticated research models in real life situations, and the development of practical integrated sand transport models for use by the coastal engineering community. The scientific team in SEDMOC comprises researchers from four leading research institutes and nine universitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multi-functionalization of wood with bio-based approach  MULTI-WOOD'.

assistant: **Objectives**

Wood is recognized as an attractive alternative to several traditional building solutions, and it is often called a building material of the 21st century since it can efficiently sequester carbon, balancing emissions from other materials. As a biological material, wood is sensitive to environmental conditions and microorganisms; therefore, it requires protective measures to extend its service life in outdoor applications. Despite the current demand for improvement of wood performance and considering technologies with low environmental impact, there is limited research on treatments and formulations that use green alternatives and improve critical properties simultaneously.The ambition of the MULTI-WOOD project is to provide multi-functional treatments to entirely protect wood from nano- to microscale using alternative sources of chemicals generated during the lignocellulosic bioconversion and/or from the pulp and paper industries. The project aims to develop innovative strategies for the improvement of four key wood properties: hygroscopicity, resistance against fire, UV, and biotic factors based on alternative, recently underutilized bio-based formulations. Proposed methodology and treatments target reduction in the toxicity of the modification processes, extend service life, elongate maintenance cycles, and thus, lower the negative impact on the environment. The MULTI-WOOD project will stimulate innovation and knowledge transfer between the host and ER by building a solid research and industrial network, organizing events, mentoring young researchers and managing projects, the ER will gain research and scientific skills and acquire a new set of competencies to reach professional maturity and independence after the fellowship.


**Keywords:** Forest biomass residues, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'In vitro evolution of a new family of metal-sensors by phage display'.

assistant: **Concept**

In recent years, a new family of metal-responsive transcription factors has been identified, two of which, SmtB and a novel sequence designated as PacR, are present in cyanobacteria (Prof. Robinson's lab). Most of these metal-responsive repressors control the expression of proteins involved in metal ion homeostasis or detoxification, and are characterized by their ability to sense specific metal ions. The existence of a family of related regulatory proteins which differ in the spectrum of metal ions that they sense provides a unique opportunity to identify the determinants of metal specificity. The objective of this program is to identify the metal-binding sites in these repressors and to establish what structures determine the different preferences within the spectrum of metal-ions sensed by these repressors. The relationship between the structure and the function of the metal-binding site of several members of this repressor family, in particular of SmtB, the repressor of the first (characterized) prokaryotic metallothionein gene, smtA, and PacR, the putative repressor of a gene encoding a predicted copper ATPase, will be analyzed in detail to understand how these metals are perceived by cyanobacteria. We will use the strategy of in vitro evolution by phage display technology to modify ligand affinity and specificity of SmtB and PacR. This approach will reveal which amino acids form the metal-binding site in these repressors and also lead to the engineering of novel metal-sensor proteins. There are potential long-term applications for the development of metal-specific biosensors and for engineering metal-resistance/-accumulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A web-based Decision Support System to score forest understorey dynamics in response to management interventions in a changing world' (UnderSCORE), addressing dissemination and exploitation.

assistant: **Impact**

Currently, forest management models focus predominantly on tree dynamics following interventions, and tend to ignore the plant species found below the trees on the forest floor (the understorey). This is a crucial oversight, as the understorey is the major component of biodiversity, provides vital ecosystem services, and can influence the overall functioning of the forest. As such, there is a need for a user-friendly tool to help predict key understorey plant performance indicators (e.g. biodiversity, share of species of conservation concern) across environmental contexts (e.g. macroclimate space, land-use history) and overstorey tree management (e.g. timber species choice, forest management systems, rotation times).Based on the outcomes and insights from the ERC Consolidator Grant PASTFORWARD we propose to solve the lack of a user-friendly tool for understanding vital understorey dynamics by first creating a prototype web-based Decision Support System (UnderSCORE). Creating this tool will transfer the research output of the ERC PASTFORWARD project into a form that is of direct use for policy makers and forest managers. Such a tool is not currently available but clear legal and societal imperatives (e.g. Natura 2000, European Biodiversity Strategy) require its development, and provide the context for its adoption by potential users.The first stage of this proof-of-concept project is to explore and confirm the understorey output data end users require, the input data they could typically provide, and the type of management interventions that they would typically contemplate. In the second stage, we will use this end user information, in conjunction with the distinctive scientific output of PASTFORWARD, to develop a prototype of the DSS. After the development of a first p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Intelligent Design and Experimental Application of Spectral Splitting and Selective Surfaces for Sunlight'.

assistant: **Innovation**

This project aims to develop advanced materials solutions for next generation solar energy harvesting systems: Concentrated Solar Thermal (CST) technologies, generating heat, can be combined with Photovoltaic (PV), generating low-cost electricity, in compact hybrid PV-CST systems where PV cells replace mirrors on the concentrators. This type of system will maintain current solar electricity production costs while adding simultaneous heat generation for various end users (residential, commercial, industrial), including the option of thermal storage to address solar intermittency and enable on-demand electricity and heat production. For this application, innovative spectrally selective surfaces are necessary, especially “PV mirrors” splitting the solar spectrum, transparent towards the underlying PV cells and reflective towards the thermal absorbers placed at the focus of the concentrators. Highly absorbing, low emissive solar selective coatings adapted to the truncated solar spectrum are also needed for the thermal absorbers.In this project, these selective surface properties will be achieved by developing efficient multilayered thin film architectures. The latter will first be designed by numerical simulations using advanced optimization methods, using in-house SolPOC open source code. Efforts will be put on reducing environmental impacts, by selecting sustainable materials and minimizing development time and cost through extensive optical simulation. The best solutions will be synthesized by vacuum sputtering deposition to validate the coatings feasibility. Thermo-optical characterizations will validate their performance. Comparisons with simulated optical behavior will validate the design methods, providing a reliable and free tool for developing optical surfaces and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Correlated frontiers of many-body quantum mathematics and condensed matter physics' (CORFRONMAT) targeting Horizon 2020.

assistant: **Abstract**

One of the main challenges in condensed matter physics is to understand strongly correlated quantum systems. Our purpose is to approach this issue from the point of view of rigorous mathematical analysis. The goals are twofold: develop a mathematical framework applicable to physically relevant scenarii, take inspiration from the physics to introduce new topics in mathematics. The scope of the proposal thus goes from physically oriented questions (theoretical description and modelization of physical systems) to analytical ones (rigorous derivation and analysis of reduced models) in several cases where strong correlations play the key role.In a first part, we aim at developing mathematical methods of general applicability to go beyond mean-field theory in different contexts. Our long-term goal is to forge new tools to attack important open problems in the field. Particular emphasis will be put on the structural properties of large quantum states as a general tool.A second part is concerned with so-called fractional quantum Hall states, host of  the fractional quantum Hall effect. Despite the appealing structure of their built-in correlations, their mathematical study is in its infancy. They however constitute anexcellent testing ground to develop ideas of possible wider applicability. In particular, we introduce and study a new class of many-body variational problems.In the third part we discuss so-called anyons, exotic quasi-particles thought to  emerge as excitations of highly-correlated quantum systems. Their modelization gives rise to rather unusual, strongly interacting, many-body Hamiltonians with a topological content. Mathematical analysis will help us shed light on those, clarifying the characteristic properties that could ultimately be experimentally tested.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EARLY COLORECTAL CANCER: PATIENT-TARGETED AND ORGAN PRESERVING TREATMENT ECOPOP' (ECOPOP) targeting Horizon Europe.

assistant: **Abstract**

Incidence and mortality of colorectal cancer (CRC) is the second leading cause of cancer death in Europe. With current screening programs in most European countries, many CRCs are detected in an early and curable stage with excellent prognosis. The current standard treatment for early CRC is surgical tumour removal. This is considered as overly invasive especially for the growing number of elderly and frail patients. Expanding technical possibilities of local tumour removal by flexible endoscopy along with initial data supporting its oncological safety open the way to organ preserving therapy. This may result in avoiding surgery and improved patients´ quality of life (QoL). However, high-quality, long-term oncological outcome data of endoscopic removal as compared to surgery are lacking, and precise oncological risk criteria prior to the start of the therapy are urgently needed.  The current project has two major aims: a) to assess oncological efficacy, safety, and patient QoL of local endoscopic removal of early CRC as compared to surgery in 3 randomized trials, and b) to develop and test criteria in this patient population to primarily identify high-risk lesions based on novel biomarkers, endoscopic imaging, and other clinical criteria, also within an artificial intelligence-guided treatment algorithm. We propose to provide state-of-the-art assessment of new, sustainable, less invasive treatment modalities for early-stage CRC and determine patient preferences around these therapies. We will perform large, international head-to-head randomized clinical trials. These trials will allow carbon cost effectiveness analyses, biomarker research and development of clinical practice guidelines to carve out the next-generation best clinical practice for patients with early-stage