RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients' (TOPCAPI) targeting Horizon 2020.

assistant: **Abstract**

TOPCAPI will exploit the natural fabrication power of actinomycetes as microbial cell factories to produce three high value compounds: GE2270, a starter compound for the semi-synthesis of NAI-Acne, a new topical anti-acne drug in Phase II clinical trials; 6-desmethyl-tetracycline (6DM-TC) and 6-desmethyl 6-deshydro tetracycline (6DM6DH-TC), intermediates for semi-synthetic conversion to medically important type II polyketide tetracyclines (TC), e.g. minocycline, tigecycline, and the novel omadacycline, which is in Phase III clinical trials, to be used against Methicillin-resistant Staphylococcus aureus infections. Our work will focus on two bacterial host species: Streptomyces coelicolor and Streptomyces rimosus. These host species will be characterised using systems biology approaches, applying integrated data analysis to transcriptomics and metabolomics experiments, combined with predictive mathematical modelling to drive the rapid improvement of these microbial cell factories for industrial drug production using advanced metabolic and biosynthetic engineering approaches. At the same time, we will establish an expanded toolbox for the engineering of actinomycete bacteria as cell factories for other high added-value compounds.In the proposed 4-year project, we will: 1. Host engineer two new actinomycete strains for industry-level improved heterologous compound production through integrating systems biology-driven strain design and state-of-the-art genome editing. 2. Engineer the biosynthesis pathways to obtain high-efficiency synthesis of GE2270 and new pathway variants for 6DM-TC and 6DM6DH-TC as well as improve its production purity.3. Optimise the expression of the engineered target pathways in pre-engineered strains to achieve industrially viable production levels
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Dormancy of cells and organisms-strategies for survival and preservation' (2002-2006).

assistant: **Concept**

Preserving ones body and reviving it in future generations is a dream of mankind. In fact, there are important practical uses for the preservation of cells, tissues, organs and organisms or for maintaining the gene pool. Many organisms have learned in evolution to enter dormant stages, often associated with desiccation, in which they survive for long periods and then reactivate within minutes or hours.So far, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived, at ambient temperatures. Attempting to learn that lesson is the vision of SLEEPING BEAUTY".The objective is by learning from nature to develop novel concepts for cell preservation based on mechanisms with which model organisms tolerate desiccation and/or remain metabolically inactive for long periods. Studies aim at revealing the mechanisms that establish dormancy and resistance to desiccation, those that allow revival from dormant stages and the properties that make dormant stages stress tolerant. This will be achieved by studying five model organisms from diverse taxonomic phyla, using mainly modern tools of global gene expression profiling, proteomics and metabolic analyses. The results will guide further studies on the genetic regulation of these phenomena hopefully leading to sophisticated novel methods for cell and tissue preservation.This is a multi-disciplinary project crossing the traditional boundaries of ecology, physiology, biochemistry, protein chemistry, developmental and molecular biology. The project is adventurous, novel and high-risk with potential long-term impact in biotechnology, medicine and ecology. It has a defined endpoint at which an assessment can be made on the possibilities to artificially make cells, tissues or organisms dorman
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulation of chromatin compaction in response to DNA damage in mammalian cells' (CHROMATINDAMAGE).

assistant: **Innovation**

Protection of genome integrity is crucial for maintaining cell viability and preventing cancer. However, how the dynamic organisation of DNA into chromatin in the cell nucleus is orchestrated in order to allow and promote detection and repair of DNA lesions remains poorly understood. A controlled accessibility of damaged chromatin is likely critical for an efficient cellular response to DNA damage, but underlying molecular mechanisms enabling this regulation have to be deciphered. In this proposal, we describe how we will combine established techniques and a novel approach based on FLIM-FRET microscopy to quantitatively visualise chromatin compaction/decompaction in human cells and to analyse how this is regulated during the response to genotoxic stress. First, we will examine the spatio-temporal dynamics of chromatin re-organisation upon global or localised DNA damage. Then, we plan to characterise the factors involved in each step, with a particular focus on chromatin remodeling factors, in order to determine their exact functional importance for DNA damage signaling and repair. This study should provide mechanistic insight into how genome integrity is preserved in a chromatin context.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Dynamics of Supersymmetry in Curved Space'.

assistant: **Objectives**

Quantum field theory provides a theoretical framework to explain quantitatively natural phenomena as diverse as the fluctuations in the cosmic microwave background, superconductivity, and elementary particle interactions in colliders. Even if we use quantum field theories in different settings, their structure and dynamics are still largely mysterious. Weakly coupled systems can be studied perturbatively, however many natural phenomena are characterized by strong self-interactions (e.g. high T superconductors, nuclear forces) and their analysis requires going beyond perturbation theory. Supersymmetric field theories are very interesting in this respect because they can be studied exactly even at strong coupling and their dynamics displays phenomena like confinement or the breaking of chiral symmetries that occur in nature and are very difficult to study analytically.Recently it was realized that many interesting insights on the dynamics of supersymmetric field theories can be obtained by placing these theories in curved space preserving supersymmetry. These advances have opened new research avenues but also left many important questions unanswered. The aim of our research programme will be to clarify the dynamics of supersymmetric field theories in curved space and use this knowledge to establish new exact results for strongly coupled supersymmetric gauge theories. The novelty of our approach resides in the systematic use of the interplay between the physical properties of a supersymmetric theory and the geometrical properties of the space-time it lives in. The analytical results we will obtain, while derived for very symmetric theories, can be used as a guide in understanding the dynamics of many physical systems. Besides providing new tools to address the dynamics of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Social Mobility and Inequality across Italy and Europe: 1300-1800' (SMITE) under Horizon 2020.

assistant: **Objectives**

The goal of SMITE is to improve our knowledge of long-term trends in social mobility, from the decades immediately preceding the Black Death of 1347-49 up until the eve of Industrialization. The objective is not only to measure mobility, but also to understand its consequences for the economy and society at large. Very few data about preindustrial social mobility are available today, especially for southern Europe. SMITE will collect an extensive database about social mobility, measured in different ways including: economic mobility across wealth classes and occupational mobility. Archival research will be concentrated on Italy where excellent sources exist, but the Italian case will be placed in the wider European context. The few existing databases from all over the continent will be collected for comparison and direct research will be done on some regions of Europe beyond Italy, especially in France, Spain and the Low Countries.SMITE will reconstruct social mobility trends both in growing and in declining areas of Europe. The connection between social mobility and economic growth will be assessed. SMITE will also analyse in detail the connection between long-term changes in social mobility and in economic inequality, which is a novel and potentially very important research avenue. It will receive from an earlier ERC project (EINITE) the largest existing database on preindustrial inequality. It will study whether the growth in economic inequality, which seems to have characterized both northern and southern Europe during the early modern period, went hand in hand with an increase in upward social mobility or whether there were differences across the continent. In fact, upward social mobility might have slowed down in southern Europe from ca. 1600 (as some literature s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sustainable intensification of food production through resilient farming systems in West & North Africa' under Horizon 2020.

assistant: **Concept**

Large areas of agricultural land in W. and N. Africa are heavily degraded, with water scarcity, low soil fertility and poor plant health, due to use of unsuitable agronomic systems and inappropriate management. In W. Africa, poor water, organic matter and nutrient retention limit food productivity, whilst in N. Africa, salinisation, wind erosion, formation of crusts and compaction threaten rainfed cropland and silvopasture. The low food productivity, poor resilience and unsustainability of current approaches have severe socioeconomic and environmental consequences. The overall goal of SustInAfrica is to empower smallholder farmers, small and medium enterprises and various government and non-governmental organisations in Ghana, Burkina Faso, Niger, Egypt and Tunisia to successfully intensify food production and deliver ecosystem services in a sustainable and resilient manner. This will be achieved through: A) comprehensive analysis of i) local/regional target ecosystems; ii) currently applied and potential landscape, soil, water and plant health management strategies and agronomic systems; iii) relevant actors across supply/value chains; iv) business models and policies; v) challenges and threats to production; B) development of technologies, including a smart platform supporting farmers in decision-making, concerning factors assessed in A); C) implementation of field trials at target sites, combining traditional knowledge, sustainable strategies and systems (agroecology, agroforestry, organic farming) and modern technologies (developed apps/platform); D) communication/dissemination/education/training to inform stakeholders/consumers and empower smallholders (especially women/youths); E) exploiting/continuing approaches/technologies for improved productivity/ecosystem se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Analysing the function of existing and novel genetic promoters for tissue-specific expression of transgenes in Zea mays' under Fourth Framework.

assistant: **Concept**

Objective: To improve our understanding of the regulation of gene and transgene expression in an important cereal crop by promoter isolation and analysis. Targets: Promoter motifs conferring tissue specificity on the expression of associated genes will be defined for up to 50 regulatory sequences isolated from maize. The tissue targets are leaf senescence; kernel development; pollen and seedling development; roots and flowers; guard and other leaf epidermis cells. Approach: Initial characterization of candidate promoters isolated by cDNA/genomic screening or trapping with promoter-less GUS will be followed by transposon mutagenesis to define regions critical for tissue specificity. Promoter fragments thus identified will be further analysed in homologous in-vitro transcription systems and by fusion with reporters and transformation into maize. Work Package 1. Clone the following genes and isolate their promoter regions: at least 6 senescence-related cDNAs; up to 10 MADS box containing regulatory factors; 20 seedling- and pollen-specific cDNAs; one each guard cell PEP-carboxylase and K channel cDNAs. Work Package 2. Identify the following new promoters by GUS tagging: at least 4 active in senescence; 4 root/flower-specific; 5 constitutive; 5 leaf cell-specific. Work Package 3. From segregating mutant stocks evaluated over three successive field seasons, identify Mutator transposon insertions in the following regulatory sequences: at least 2 senescence promoters; at least 3 kernel MADS-boxes; up to 20 seedling/pollen promoters; 4 root/flower promoters; 5 constitutive; at least 2 leaf-cell promoters. Work Package 4. Analyse the following tissue-specific promoter regions (at least 2 in each case) by the in-vitro transcription initiation procedure: senescence; MADS-box; root
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evaluating the Delivery Of Participatory Environmental Governance using an Evidence-based Research Design' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Participation of citizens and stakeholders in environmental governance is widely believed to enhance environmental policy outcomes. This claim has, however, been challenged both on theoretical grounds and with respect to a lack of reliable evidence. EDGE uses an evidence-based approach: By combining case survey, comparative case studies and field experimentation, the project draws on complementary methods with a high natural variety and thus external validity (case survey) and those with a higher controllability and thus higher internal validity (experimentation).Case survey: Numerous single case studies are available across Europe and North America, providing a rich, but scattered and yet untapped resource of data. A sample of c.200 cases will be precisely coded and systematically compared based on a theoretical framework that provides relevant context, process and outcome variables.A sample of around 10 comparative case studies on governance processes in the course of the implementation of the EU Water Framework Directive (WFD) will be conducted.EDGE will perform one of the first field experiments in governance research. Field experiments are highly promising, yet controversially debated and in practice challenging. Around 10 cases of ongoing local WFD implementation processes will be subject to random selection of a participatory or non-participatory governance design.Data from all three sources will be stringently analysed using the same analytical scheme. Results will be analysed with statistical and set-theoretic methods. EDGE thus aims to drastically improve the scientific knowledge on whether and under what conditions participation actually improves policy delivery in environmental governance, thus radically informing scholarly research and political practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of plasmonic quorum sensors for understanding bacterial-eukaryotic cell relations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determination of the interaction mechanisms between mixed colonies and their manipulation through external parameters. This will involve a first stage related to the careful design of the most appropriate nanoparticle morphology and composition, as well as an understanding of their specific assembly processes (both on substrates and in solution), so that the collective plasmonic response will be optimized towards the enhancement of the Raman signal of the probe molecular codes. Coating of the nanoparticle supercrystals with a mesoporous layer will be required to protect them against contact with bacteria and cells, while permitting contact with the QS signaling molecules. Ultimately, when the sensing system has been optimized and its performance demonstrated for monitoring of QS signals and colony growth, two final and important goals will be pursued. First, the interaction between mixed colonies (bacteria-bacteria and bacteria-eukaryotic cell) will be monitored in order to get information about synergic or antagonist (toxicity) QS mechanisms during the growth and proliferation of different bacteria and interspecies. This goal will permit the design of in vitro experiments where a bacterial strain may be manipulated by means of external introduction of the appropriate QS signaling molecules. Finally, the major challenge will be the practical demonstration of the ability of these new ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Revealing the physics of switching mechanism in 2D materials based memristor devices (2DMEM)' to be submitted under Horizon Europe.

assistant: **Abstract**

One of the most promising non-volatile memory devices and a building block of brain-inspired neuromorphic computing architectures is memristors. The advent of two-dimensional materials (2DMs) has opened a plethora of opportunities in realizing ultra-scaled device dimensions for future logic and memory applications. Despite different hypotheses proposed in the literature, mainly based on analytical models, significant debate is still ongoing, demonstrating the need for a systematic and atomic-scale study. 2DMEM aims to reveal the fundamental physics lying behind each step of device functionality, e.g., SET and RESET. 2DMEM builds on the complementarity of my strengths on investigating the electronic properties of 2DMs, and simulation expertise and infrastructure at the Host Institution, Tyndall, where access to a large interdisciplinary suite of experimental data on the fabricated 2DM memristors is uniquely available. 2DMEM’s specific objectives are to exploit the experimental data of 2DM properties, and to incorporate ‘realistic’ material and device features into crossbar structures by employing an advanced simulation platform. My career development will benefit from the supervision of Dr Lida Ansari, with the mentorship of Profs Paul Hurley, Stephen Fahy and Dr Farzan Gity, who are established research leaders at Tyndall and at Ireland’s materials research center (AMBER). Through this Fellowship, I will develop my scientific, transferable, and management and leadership skills. These skills are essential for achieving my primary career objective of developing into an independent research leader, and will increase my employability in the academic sector. This MSCA Fellowship also creates a unique starting point for me to directly interact with INTEL, who have expressed g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Demonstration of intelligent eco-solutions for It-heavy high profile office buildings'.

assistant: **Innovation**

The aim is to demonstrate the intelligent solutions for typical new high profile office-buildings with extensive use of IT-systems, relevant for easy and large-scale replication in many types of buildings.The overall goals of the actual ECO-building are:- To reduce the energy consumption and CO2 emission related to cooling by 75-80%.- To reduce peak load of cooling to less than 50% of average load.- To reduce the heating energy consumption and related CO2 emission by 35-50%- To integrate use of renewable energy, > 30%.- To reduce energy consumption for general lighting to below 50% of practice.- To increase the quality of the working and social climate.- To disseminate the used ECO-solutions of the high-profile building.