RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Innovative Transport Equipment for Coal, Coke and Ore'.

assistant: **Objectives**

The raw material supply of the steel industry is currently carried out with old-fashioned special wagons overaged, inflexible and in desperate need for modernization and cost-efficient replacements. Taking this initial situation into account Innofreight developed the multipurpose ultra-light container waggon, the ‘InnoWaggon’ and a special container for the transportation of iron ore, the ‘RockTainer’. Together with the already well-established WoodTainer (for coal, coke and other light bulk goods) the InnoWaggon and the RockTainer provide all features for innovation. Advantages of the Innofreight-system range from lower acquisition costs, lower tare weight and higher payload to higher utilization rates, faster handling processes and lower costs of operation. The higher utilization rate results mainly from the facts that the waggon provides compatibility with all standard-sized containers and can be used in all markets. At the borders, where different railway gauges converge, the manipulation of the containers does not result in any problem as the containers can be reloaded quickly between trains and therefore facilitate the trans-European railway traffic. Already market leader and technological leader in the supply of the paper industry regarding woodchips, Innofreight strives to achieve the same position in the steel industry – a market three times larger. Therefore Innofreight plans to conduct a feasibility study in order to figure out an optimal way to conquer the market for railway equipment regarding raw material supply with special focus on the steel industry. This feasibility study will cover an investment plan, subsidies, ICT infrastructure, HR and marketing efforts. Furthermore a new organizational company structure and the required financing strategy will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Privacy and emerging fields of science and technology: Towards a common framework for privacy and ethical assessment' (PRESCIENT) under Seventh Framework.

assistant: **Objectives**

Privacy is a multifaceted concept, a moving target and a salient topic in technology policy-making. PRESCIENT will provide an early identification of privacy and ethical issues arising from emerging technologies and their relevance for EC policy. It will contribute to the quality of research in the field of ethics, by distinguishing between privacy and data protection and analysing the ethical, legal and socio-economic conceptualisations of each. The project has four stages. The first stage is ANALYSIS: the partners will provide a state-of-the-art analysis of privacy and data protection as conceptualised from an ethical, socio-economic and legal perspective. The second stage is CASE STUDIES wherein the partners will identify the privacy, data protection and ethical issues arising from five different emerging technologies and their applications. The third stage focuses on CITIZENS. The partners will analyse various existing surveys to assess citizen concerns and knowledge of the way in which their data are collected, stored and used and their concerns about new technologies and how their concerns have changed over time. The partners will examine 20 top websites and interview data collectors to assess how easy or difficult it is for citizens to access their information and to find out it is being used. The fourth and final stage focuses on development of a NEW FRAMEWORK FOR PRIVACY AND ETHICAL IMPACT ASSESSMENTS. The partners will develop four scenarios as an element in this new framework, which is based on an integration of the results of this study and on privacy impact assessment guidelines such as those of the UK. The partners will invite a multi-disciplinary panel of external experts to comment on the deliverables and discuss issues raised in a workshop at each stage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Autocatalysis: A bottom-up approach to understanding the origins of life', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The origin of life is not well understood, and is one of the great remaining questions in science. Autocatalytic chemical reactions have been extensively studied with the aim of providing insight into the principles underlying living systems. In biology, organisms can be thought of as imperfect self-replicators, which produce closely related species, allowing for selection and evolution. Autocatalysis is also an important part of many other biological processes. This project aims to develop new autocatalytic reactions where two simple chemical building blocks come together to give a more complex product, and then the product aggregates to give primitive cell-like structures or ""protocells"" such as micelles or vesicles. The protocells allow the starting materials to mix more efficiently, speeding up the reaction in time and giving rise to complex behaviour of the protocells. These reactions will serve as models that I hope will contribute to understanding how cell-like systems can emerge from simpler chemicals and be relevant to how life started on earth.This project will give the opportunity to study chemical systems that may be able to evolve in time, allow development of useful chemical models of important biological processes, and provide ‘bottom-up’ approaches to synthetic biology. This research will potential allow the study evolution in a new ways, develop technology useful to a number of scientific fields, and potentially shed light on the processes that allowed chemistry to become biology on the primitive Earth.""


**Keywords:** Autocatalysis, self-reproduction, origins of life, protocells, phase behaviour, chemical evolution, systems chemistry, supramolecular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European women in mathematics project' (EWIMP) under Fifth Framework.

assistant: **Objectives**

Women are significantly underrepresented in mathematical research in all European countries. A wider presence of women is necessary, because of the prominent role of mathematics within society, and not to exploit the abilities of a large section of the population is a tragic waste of resources. The objective of this proposal is to enhance the potential of women mathematicians, to participate in academic research at all levels. It is proposed to meet this objective via conferences for women mathematicians and setting up a web-based mentoring scheme to enable mentors and mentees to form connections. The expected benefits of this proposal are an increase in participation of women in mathematical research in Europe and further development of cooperation between EU and other countries to promote women in science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Frontiers of Oxidative Protein Folding and Assembly: Catalysis of Disulfide Formation Downstream of the Endoplasmic Reticulum' (QSOX1BIOFUNC) targeting Seventh Framework.

assistant: **Abstract**

Quiescin sulfhydryl oxidase (QSOX), which catalyzes disulfide cross-linking in proteins, is up-regulated in many tumor types. QSOX is the only disulfide catalyst to undergo regulated secretion from cells, but the biological role of the enzyme, its substrates, and its mechanistic link to cancer are obscure. In addition to determining the first X-ray crystal structures of QSOXs, we recently discovered that QSOX is required for incorporation of laminins into basement membrane extracellular matrix (ECM). Fibroblasts depleted of QSOX make defective ECM that fails to support adherence and migration of tumor-derived cells in co-culture, but ECM composition and cell migration are restored by supplying recombinant QSOX exogenously. Our observations suggest a role for QSOX in building a microenvironment favorable for tumor cell survival and migration. We are motivated by a number of observations to expand our studies of QSOX enzymes. First, QSOX is ideally suited for single-molecule fluorescence resonance energy transfer experiments, which will shed light on hitherto invisible steps in the QSOX reaction cycle. Second, we have evidence for additional functions of QSOX with intriguing links to lipid metabolism and lipid storage diseases, and we are compelled to discover the pathways involved. Third, the modulation of tumor/stromal interactions is a promising direction for anti-metastatic cancer therapy, so the QSOX inhibitors we are developing may find use in the clinic as well as in the laboratory. Fourth, the complex QSOX expression patterns in developing and adult mammals prompted us to generate a conditional QSOX knockout mouse with which to explore QSOX function in vivo. In consolidating my laboratory, I will continue to rely heavily on my strengths as a structural biologist w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From Cells to Organs on Chips: Development of an Integrative Microfluidic Platform' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

We shall develop a microfluidic and microsystems toolbox allowing the  construction and study of complex cellular assemblies (“tissue or organ mimics on chip”), in a highly controlled and parallelized way.  This platform will allow the selection of specific cells from one or several  populations, their deterministic positioning and/or connection relative to each other, yielding  functional assemblies with a degree of complexity, determinism and physiological realism unavailable to current in vitro systems We shall in particular develop “semi-3D” architectures, reproducing the local 3D arrangement of tissues, but presenting at mesoscale  a planar and periodic arrangement facilitating high resolution stimulation and recording. This will provide biologists and clinicians with new experimental models able to bridge the gap between current in vitro systems, in which cells can be observed in parallel at high resolution, but lack the  highly ordered architecture  present in living systems, and in vivo models, in which observation and stimulation means are more limited.  This development will follow a functional approach, and gather competences and concepts from micr-nano-systems, surface science, hydrodynamics, soft matter and biology. We shall validate it on three specific applications, the sorting and study of circulating tumour cells for understanding metastases, the creation of “miniguts”, artificial intestinal tissue, for applications in developmental biology and cancerogenesis, and the in vitro construction of active and connected neuron arrays, for studying the molecular mechanisms of Alzheimer, and signal processing by neuron  networks.  This platform will also open new routes for drug testing, replacing animal models and reducing the health and economic risk of clinic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Reseau thematique Europeen sur: le travail, les jeunes et le syndic alisme' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The creation of a European network on the theme of Work, young people and trade unions should make it possible to tackle the issue of social exclusion/integration in Europe, by examining the interaction of these three fields. The problems, which young people are facing, seem to be the same in different European States, even if they arise in more or less different ways according to the country. Every society is concerned about them in relation to the future. Given existing studies on the subject, it seems necessary to go into greater depth in this field of research. It is rare for changes in work to be studied from the point of view of developments amongst young people. This is even more the case, as far as a comparative approach at the European level is concerned. However, young people's living and working conditions seem to say a lot about on-going changes. Furthermore, young people's working and living reality and the way they evaluate them and their relationship to work have something to do with the way they relate to trade unionism. The proposed network will be made up of representatives of European trade unions (and similar bodies). It will make it possible to know about trade union policies, proposals and opinions on social exclusion/integration, as well as its mechanisms, causes and policies that are implemented... Meetings will be organised by each partner of the network on a particular aspect of the general theme of Work, young people and trade unions": young people's relationship to work, destructuring/restructuring of social identity, training, trade unionism, relations between generations, payment of young people's work and their wages. It will not be a question of simply presenting existing studies country by country, but also of having discussions about mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Preclinical development of drugs and drug delivery technology for the treatment of inherited photoreceptor degeneration'.

assistant: **Objectives**

Dysregulation of cGMP is a pathological hallmark of inherited retinal degenerations (RD) affecting photoreceptors, the sensory cells of the retina. These RDs, including Retinitis Pigmentosa, Lebers Congenital Amaurosis, and Achromatopsia, are major causes of blindness, affecting approximately one in every 2000 individuals worldwide, and remain without effective treatment. In photoreceptors, cGMP is produced by retinal guanylyl cyclase (GC). The two main cGMP targets are cyclic nucleotide gated ion channels (CNGC) and cGMP-dependent protein kinase (PKG). Since attenuation of PKG and CNGC activity can reduce photoreceptor cell death, both proteins constitute potential targets to prevent RD. Recent data suggest that blocking retinal GC may also constitute a viable therapeutic approach.This consortium will study and develop targeted compounds and delivery systems aimed at preventing photoreceptor damage in preclinical disease models. Towards this goal, two SMEs have teamed up with three academic research groups focused on retinal degeneration: the German company BIOLOG specializes on development of cyclic nucleotide based drugs targeting PKG, CNGC, and GC; the Dutch company to-BBB develops systems to deliver drugs across the blood brain/retinal barrier (BBB, BRB, resp.); the groups of V. Marigo (Modena, Italy), P. Ekström (Lund, Sweden), and F. Paquet-Durand (Tübingen, Germany) have a strong and joint collaborative track record of studying photoreceptor degenerative mechanisms as well as on testing and evaluating drug treatment effects. Manufacturing of the most promising drugs fitted to a suitable delivery system will be scaled up towards clinical-size batches and studied towards efficacy, toxicology and off-target effects in model animals. The results of the project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Trusted Extremely Precise Mapping and Prediction for Emergency Management' under Horizon Europe.

assistant: **Concept**

TEMA will greatly improve Natural Disaster Management (NDM, e.g., for wildfires, floods) by automating precise semantic 3D mapping and disaster evolution prediction to achieve NDM goals in near-real-time. It will analyze and fuse many heterogeneous extreme data sources: smart drone and in-situ sensors, remote sensing data, topographical data, meteorological data/predictions and geosocial media data (text, image and videos). TEMA will focus on the extreme nature of the data, due to their varying resolution and quality, very large volume and update rate, different spatiotemporal resolutions and acquisition frequencies, real-time needs and multilingualism. It will develop an integrated, ground-breaking NDM platform, focusing on real-time semantic extraction from multiple heterogeneous data modalities and sources, on-the-fly construction of a meaningful semantically annotated 3D disaster area map, prediction of disaster evolution and improved communication between service providers and end-users, through automated process triggering and response recommendations. Semantic analysis computations will be distributed across the edge-to-cloud continuum, in a federated manner, to minimize latency. Extreme data analytics will be performed in a trustworthy and transparent way, by greatly advancing state-of-the-art AI and XAI approaches. The constantly updated 3D map and the disaster evolution predictions will form the basis for an advanced, interactive, Extended Reality (XR) interface, where the current situation will be visualized and different response strategies will be dynamically evaluated through simulation by NDM personnel. The innovative, scalable and efficient TEMA platform will provide precise NDM support, based on extreme data analytics. It will be validated on two critic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Remote sensing INdicators for DROught monitoring' under Horizon 2020.

assistant: **Concept**

Droughts affect most parts of the world. According to the recent previsions of the Intergovernmental Panel on Climate Change1 (IPCC), more frequent and severe droughts are expected. This observation makes it a priority to improve the existing methods of monitoring droughts and their impact on terrestrial ecosystems. Early warning systems need to be developed. Remote sensing (RS) technologies are well-placed to provide such monitoring. Thanks to RS, droughts can be monitored at large scale and at short time resolution (e.g., daily). The proposed project “INDRO” will focus on the definition of new RS-based indicators able to monitor vegetation status and how it is responding to drought. For example, the RS indicators implemented at the moment within the European Drought Observatory (EDO) early monitor system are not sensitive to rapid changes in plant photosynthesis since these indicators have no direct link to plant photosynthetic functioning. The project will analyse the relationships between ecophysiological variables, light use activity (LUE) and existing RS indicators calculated with the data from several satellite sensors. This analysis will reveal which sensors, and which spatial and temporal resolutions are best at quantifying drought. A new generation of RS indicators will be developed to give a better description of plant photosynthetic functioning in drought conditions. The project will map these new indicators for southern Europe to identify the areas affected by drought. Overall, the creation of new RS drought indicators, and the better definition of drought events they bring, will help the development of ecological models and early warning systems, and underpin new avenues for the improvement of national and international drought mitigation and adaptation st