RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel ion channels in plants' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The NICIP network programme encompasses the application of the specific technologies used in plant research. These different disciplines, technologies, and approaches are integrated in this project under the joint objective of gaining new insight into plant transport processes. Young researchers will qualify further in different disciplines including functional genomics and proteomics which will give them much better opportunities to find employment in academia as well as in the biotechnology industry. They will have the chance to get to know industrial partners during working visits and thus will extend their experience in industrial application of plant research. By actively transposing training measures like presentations of scientific results, working visits in another laboratory of the network, and instructing co-workers being involved in the project they will be trained in communication and project management skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The developmental and evolutionary basis of human intersubjectivity' under Horizon 2020.

assistant: **Concept**

This research aims to unravel the ontogenetic and phylogenetic roots of the unique human intersubjectivity. Empathy forms the basis of intersubjectivity. In the first part of the research, we address empathy development in young, 6-16-month-old infants who engage in interactive, intentional communication but do not yet cognitively represent others’ mental states. They may, however, attend to and show concern of others’ emotional states, indicating dispositional empathic orientation. This tendency is tested in a peer context, involving emotions of positive and negative valence. In addition, we assess the infants’ early communicative and prosocial behaviours in the emotionally charged situation. This will reveal the early developmental phases of the fundamental base for intersubjectivity. In the second part of the research, the evolution intersubjectivity is tested by assessing empathy in non-human primates. According to the recent cooperative breeding hypothesis, humans evolved as cooperative breeders, which increased sensitivity and motivation to attend to and show concern of others’ emotional states. The hypothesis is tested by assessing rudimentary empathy in common marmosets, a distantly related cooperatively breeding monkey. To allow full comparability, we will use identical methods in the infant and the marmoset studies. The study incorporates theoretical backgrounds and methods from several disciplines, i.e., comparative cognition, animal behaviour, developmental psychology, evolutionary anthropology, and sociological interaction research. The multidisciplinary approach yields understanding of the emotional and cognitive foundation of intersubjective interactions no single discipline can achieve alone. Moreover, the study yields fruitful prospects for future resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sliding Bearing Materials made from Monotectic Alloys' in the context of a Fourth Framework call.

assistant: **Objectives**

It is proposed to create a research network for the investigation of monotectic alloys and their application as advanced sliding bearing materials. The miscibility gap in the liquid state of monotectic systems leads to the separation of the melt in two liquids of different composition. A dispersion of the liquids leading to materials consisting of a matrix with a homogeneous distribution of a second phase would open a broad variety of applications. Most promising applications are advanced materials for sliding bearings suspending all movable parts in e.g. car engines like camshaft and piston bolt. The results on tribological behaviour and fatigue strength of aluminium based monotectic alloys achieved so far make them to potential candidates for bearing materials to meet the increased property requirements of automobile engines. The research activities in the network envisaged are the investigation of decomposition and solidification behaviour and production routes of advanced bearing materials from monotectic Al alloys as well as fabrication procedures of sliding bearings. The exploratory work for the network will be carried out by interrelated and iterative efforts like the identification and acquisition of new participants by the analysis of current activities, procurement and dissemination of information and the preparation of a provisional work plan for the Implementation Phase demonstrating the competence and the willingness of the partners. Finally a meeting with promising candidates will be organised. It is intended to establish a consortium comprising research centres and university institutes for basic materials science, basic process investigations and fundamental materials characterisation, companies for the development of casting, forming and fabrication pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Atomic force microscopy study of innate immune response complexes' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The complement system is important in the first-line defense against infections and for the generation of specific immune reactions. The mannan-binding lectin (MBL) and the MBL-associated serine proteases (MASPs) provide a recently discovered pathway to the activation of complement. Low levels of MBL are linked to an increased susceptibility to microbial infections and autoimmune diseases. The understanding of the MBL pathway and the mechanism of activation remain largely speculative. The goal of this project is to study the structure of the MBL/MASP complex and the structural changes associated with the activation of the MASPs with sophisticated atomic force microscopy (AFM) techniques. The first aim of this project is to localize, for the first time, the MASPs in the complex. For this, a modified AFM-tip using mannose-fictionalized carbon nanotubes will yield chemical contrast which allows to distinguish clearly between the sugar recognizing domains of the MBL and the MASPs in the complex. The subsequent aim is to directly visualize the proposed conformational change of the complex on activation. I will study the mechanics of the activation of the complex using the AFM's ability to study biomolecules at work in native environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Best Practices for Pv Water Pumping and Purification Programmes. Lessons from Selected Experience in Morocco'.

assistant: **Objectives**

The general objective is to disseminate, among all the actors involved in PV water pumping, the relevant lessons from a very successful project realised in the South of Morocco under the auspices of the European cooperation. For this, the particular objectives are:- Elaboration of guidelines for implementing PV water pumping and purification systems, considering technical, social and managerial aspects;- Publication and diffusion of a booklet with such guidelines, also including the description of the above -mentioned project in Morocco, as a good example;- Organisation of a Seminar Solar Energy and Water Purification Systems" in Morocco."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Migration trajectories, natural experiments and effects of small-area contexts on health: a privacy-preserving linkage study of routine and primary data among resettlement refugees' (INTERSECT).

assistant: **Innovation**

The health effects of the migration trajectory, from pre- to post-migration in new environments, have yet been poorly studied. Methodological challenges and selection effects limit the possibilities for causal inferences on how differences in social, economic, or political factors at small-area level affect variation in health among migrants (e.g. differential mortality or self-reported health). Knowledge about such relations would not only inform better and health and integration policies for migrants. Considering migrants as humans in new environments (not as singularity), may allow to conclude on the relationship between context and health more general, and inform public health beyond immigration. However, randomisation of individuals into new contexts is not possible, and establishment of prospective cohorts (from pre- to post-migration settings) is challenging, resource-intensive and prone to selection bias. The aim of INTERSECT is to study human mobility and health consequences of different social, economic and policy environments at small-area level. To this end, INTERSECT builds on three innovations: i) it re-constructs the migration trajectory by using existing data among German-bound re-settlement refugees through data-linkage or distributed computation techniques, ii) it capitalises on mandatory dispersal as natural experiment to minimise selective migration into contexts, iii) it prospectively collects primary data on health of resettlement refugees and combines these with administrative and contextual data. Using these methodological innovations, INTERSECT creates a unique research infrastructure that allows answering important research questions on social, economic and political factors at small-area level which causally explain A) mortality differences am
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Revealing the fundamental principles of picobodies with broad-spectrum and redox-responsive antibacterial activity' (PicoBody) under Horizon Europe.

assistant: **Objectives**

Antimicrobial resistance is a burning global issue. The available antimicrobials are losing efficacy as resistant bacteria arise, but the industry does not invest enough into antibiotic discovery due to low expected revenues. Natural antimicrobial peptides (AMPs) hold great promise as blueprints for new antibiotics. However, there are few known natural AMPs with sufficiently high potency and low toxicity that enable applications in veterinary and human medicine. As a result, the research on natural peptide antibiotics has been obstructed. New natural AMPs are needed urgently.  I propose for the first time that picobodies, recently discovered peptides part of natural cow antibodies, have potent antibacterial activity. In contrast to known mammalian AMPs, picobodies are exceptionally diverse due to the unique bovine immune system. Moreover, all picobodies contain disulfide bonds that enable a redox regulation of their activity (unlike common antibiotics). I suggest that redox-activated picobodies target bacteria in infection sites characterized by a reducing environment such as persistent bacterial biofilms.  In PicoBody, I have 4 major objectives: (i) interrogate natural picobody repertoires for antibacterial activity, (ii) investigate if cows can develop antibacterial picobodies against essential bacterial targets, (iii) understand how the redox environment regulates the antibacterial picobody activity, and (iv) evaluate the activity of antibacterial picobodies using in vitro and in vivo models. To achieve my goals, I will employ a multidisciplinary approach based on protein science, molecular biology, microbiology, machine learning, and lab automation. The project will establish key methods for the identification of antibacterial proteins, reveal basic insights about t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Projecting the GDR on Screen. Film Festivals and Cultural Diplomacy in Cold War Germany'.

assistant: **Innovation**

This project explores how the German Democratic Republic used film festivals in the West as a form of cultural diplomacy between 1949 and 1989. For the first time in scholarship, this project considers the different ways in which governments, artistic bodies and individuals viewed the opportunities of the Berlin Film Festival, the Cannes Film Festival and the Venice Film Festival as ways for the GDR to achieve cultural prestige and political capital in the West. Instead of presenting cultural diplomacy as a ‘top-down’ process instigated and tightly controlled by state officials, this research foregrounds the roles of artistic institutions, filmmakers and festival organisers in establishing lines of communication in-between and outside of formal channels. The significance of this extends beyond the Cold War: by focusing on the role of state and non-state actors, the research allows for better understandings of how cultural events can be used to transcend political impasses today and in so doing also speaks directly to the European Commission’s 'New European Agenda for Culture'.Led by an outstanding researcher with a proven publication record, this project will allow Dr Ward to develop further the core research, training and professional skills needed as leading international academic in the humanities and emerge as an independent researcher. By working with sector-leading cultural historians at Leipzig University, Dr Ward will hone her specialist research skills and undertake a targeted training programme to equip her with key research and professional skills needed to excel in academia. These skills will be complemented by a carefully designed communication and dissemination strategy to ensure that, upon completion of the fellowship, she has the key markers of academic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Model theory of finite and pseudofinite structures' under Horizon 2020.

assistant: **Concept**

The project is in model theory (mathematical logic), which concerns the expressibility in  logical languages of properties of mathematical structures (e.g. graphs, groups, rings). Model theory aims to identify borders between `tame' and `wild' objects in mathematics, and to pin down abstract notions of independence and dimension and understand the geometry of `definable sets' in a structure, often with wide-ranging applications. This project focusses on classes of finite structures (e.g. the class of all finite fields), and on the `ultraproduct' construction which converts a class of finite structures to  an infinite `pseudofinite' structure' which inherits properties of the class and is amenable to model-theoretic methods, with applications for the finite structures.  Key objectives include:(i) proving a trichotomy for pseudofinite geometries -- they should be `trivial', `group-like', or `field-like'; (ii) developing current concepts from abstract model theory for pseudofinite structures;(iii) identifying first order properties of pseudofinite groups, and constraints on their possible quotients;(iv) finding links between the model-theoretic `independence theorem', Gowers' notion of `quasi-random groups', and the Szemeredi regularity theorem in graph theory. (v) model theory of finite ordered structures, and links to finite model theory.To support his future academic research career, the Fellow, Garcia, will receive training through research  in the model theory groups in Leeds and (through a secondment) Lyon. There will be knowledge transfer to Garcia of expertise  in model-theoretic algebra of Leeds and Lyon, and Garcia will also build knowledge of finite model theory and its computer science applications. He will receive complementary training in many research skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Advanced Transparent Conductive Oxides' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The main objective of this project is the development of novel transparent conductive oxides (TCOs) with enhanced electrical properties and tuned transparency from UV to mid-IR. The innovative aspect of the project methodology is the strong correlation and interaction between theoretical first principle modelling and experimental studies. Three demonstrators have been selected to show the potential applications of the TCOs, which will be developed in this project, thus opening the way and giving the possibilities for Europe to lead in the new and emerging TCO-based technologies. TCOs show the unique combination of properties: co-existence of optical transparency in the visible region and controllability of electronic conduction from insulator to metal. Transparent conductive oxides continue to be in high demand because of the immediate applications they can find in a variety of new technologies, ranging from thin film coatings and sensor devices, to light detecting and emitting devices in telecommunications. However, the current industry standard, tin doped In2O3 (Indium Tin Oxide or ITO) suffers from the high raw material cost of indium. In addition, the non-optimal conductivity and transparency, and the chemical instability of ITO in some device structures, have limited its potential applications. Moreover, almost all TCOs used nowadays are n-type. The p-type TCOs reported to date have conductivities at least an order of magnitude lower than their n-type counterparts. If p-type materials with high conductivities and controlled transparencies could be manufactured industrially, a variety of new applications would open up, including transparent electronics and opto-electronics, organic light emitting diodes, integrated electro-optical (waveguide) sensors and functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'COMPUTATIONAL EVOLUTION OF ENZYME VARIANTS THROUGH CONFORMATIONAL NETWORKS' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Natural enzymes have evolved to perform their functions under complex selective pressures, being capable of accelerating reactions by several orders of magnitude. In particular, heteromeric enzyme complexes catalyze an enormous array of useful reactions that are often allosterically regulated by different protein partners. Unfortunately, the underlying physical principles of this regulation are still under debate, which makes the alteration of enzyme structure towards useful isolated subunits a tremendous challenge for modern chemical biology. Exploitation of isolated enzyme subunits, however, is advantageous for biosynthetic applications as it reduces the metabolic stress on the host cell and greatly simplifies efforts to engineer specific properties of the enzyme. Current approaches to alter natural enzyme complexes are based on the evaluation of thousands of variants, which make them economically unviable and the resulting catalytic efficiencies lag far behind their natural counterparts. The revolutionary nature of EnzVolNet relies on the application of conformational network models (e.g Markov State Models) to extract the essential functional protein dynamics and key conformational states, reducing the complexity of the enzyme design paradigm and completely reformulating previous computational design approaches. Initial mutations are extracted from costly random mutagenesis experiments and chemoinformatic tools are used to identify beneficial mutations leading to more proficient enzymes. This new strategy will be applied to develop stand-alone enzymes from heteromeric protein complexes, with advantageous biosynthetic properties and improve activity and substrate scope. Experimental evaluation of our computational predictions will finally elucidate the potential of t