RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proteome analysis group in Europe: Saccharomyces cerevisiae' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of this proposal is to develop unique facilities for proteome analysis and to make them available to the European Community: this will be achieved through three objectives. The first objective is to develop a unique two dimensional (2D) gel electrophoreis system. This will be simplified for general use and developed further (e.g. narrow range immobilized pH gradients and a new protein visualization system). Yeast will be used as a model system, using strains where individual genes either have been deleted or are over-expressed, to identify the role of each gene in cellular physiology. The second objective is to be able to interpret the changes with reference to known proteins. More than 1000 proteins will be positively identified and the post translational modifications of up to 250 proteins will be precisely described by MALDI nano-electrospray or ion trap mass spectrometry (MS). The third objective is to encourage others to adopt the standardised gel system so that they can interpret their own results using any or all of the data in the database The uniqueness of the 2D gel system lies in its capability to produce highly -comparable, high resolution 2D gel patterns of yeast proteins in a variety of laboratories. This breakthrough opens a number of exciting possibilities. Because the images are so similar, all the image data can be built into a single image-based database This will be the first time ever that different laboratories will be able to contribute 2D gel data to a common database. It will also permit and encourage the participation of additional labs: each lab that establishes this gel system will thus be able to interpret their own data with the full weight of the entire database. To make this possible we will develop new user-friendly software. Stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New lab-on-a-chip microsystems based on active transport by synthetic micro/nanomotors' (LOCNANOMOT), addressing dissemination and exploitation.

assistant: **Impact**

The IOF project LOCNANOMOT aims to design new miniaturized Lab-on-a-Chip systems for multiplexed detections using functionalized artificial micro/nanomotors modified with different receptors. To achieve this goal, a primary challenge of the outgoing phase (University of California, San Diego, USA) is the development of new receptor-functionalized catalytic micro/nanomotors capable of performing multiple nanoscale operation. The second goal will be focus on the integration of the newly developed micro/nanomotors into LOC devices. These evaluations not only contribute to the development of new LOC formats with a wide range of medical and analytical applications, but will also train the Fellow in novel and powerful research techniques. Therefore, this fellowship will provide the applicant with high level skills, which will be transferred to the return phase (University of Alcalá, Spain) in the third year, fulfilling the objectives of the ""Outgoing International Fellowship"". In this context, the primary goal of the return phase will focus on the applicability of these new devices for the isolation and detection of contaminants in foodstuffs. This project addresses one of the main thematic areas of the European Research Area of the FP7 (Nanoscience, Nanotechnology, materials and new production technologies) and is highly related to others (health and food, agriculture and biotechnology). The innovative character of this proposal lie in the integration of the active transport properties of nanomachines in LOC systems. This novel systems will lead to future new biomedical, analytical and technological applications in pathogen detection, clinical diagnosis, forensic science, DNA analysis, food safety, etc. On overall, the project will advance the development of new LOC device
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Large-Scale Demonstration of Advanced Smart GRID Solutions with wide Replication and Scalability Potential for EUROPE' (GRID4EU).

assistant: **Concept**

Grid4EU project is an innovative SmartGrid project proposed by a group of Distribution System Operators (from Czech Republic, France, Germany, Italy, Spain and Sweden), in close partnership with a set of electricity retailers, manufacturers and research organizations.Adopting a systemic approach and organized around large-scale demonstrations networks located in six different countries, its structure is built to facilitate dynamic knowledge sharing, technical assistance and review.The project will run over a 51 month period.Grid4EU aims at testing in real size some innovative system concepts and technologies in order to highlight and help to remove some of the barriers to the smart grids deployment and the achievement of the 2020 European goals. These barriers may be technical, economic, societal, environmental or regulatory barriers.It focuses on how distribution system operators can dynamically manage electricity supply and demand, which is crucial for integration of large amounts of renewable energy, and empowers consumers to become active participants in their energy choices.Ultimately, these innovative concepts and technologies should cost-effectively increase the network’s reliability, flexibility, and resiliency.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Coordinated Development of Inhibitors and Biomarkers for Resistance to Antiangiogenics in Cancer - AngioResist' (AngioResist) under Horizon 2020.

assistant: **Objectives**

Many anti-angiogenic drugs are clinically used in several types of cancer to block angiogenesis, impair tumor growth, progression and dissemination. Nevertheless, clinical trials report emergence of resistance to treatment and a failure in long-lasting effects of these therapies. To date, resistant patients do not currently have any established, proven alternative therapeutic possibility and the medical field is moving towards a careful selection of subgroups or subtypes of patients that have to be treated with each one of the available second-line targeted drugs. For this relevant unmet medical need, many laboratories and pharmaceutical companies have focused on developing new biomarkers and new drugs to fight anti-angiogenic resistance, but up to date, there is no proven established biomarker or method to predict which patient’s tumor is resistant to antiangiogenic therapies and which drug is capable of blocking this resistance to therapy.     AngioResist PoC aims at solving the existing patient selection gap in the treatment of cancer that is therapeutically resistant to antiangiogenic drugs. Based on data generated from our ERC project and two filed European Patent applications, AngioResist PoC will transform the acquired basic knowledge into an Innovation project, to validate a novel biomarker of response/resistance to antiangiogenics together with a new inhibitor for the treatment of these selected patients. The project will coordinately perform the preclinical phases of development of the drug compound and the biomarker, with the final aim of licensing them both to a selected partner during the clinical phases.  Together with our licensee, we aim at the final distribution of a therapeutic drug that will be delivered with a biomarker kit for the selection and trea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Phenomenology of strings: generalized structures, non-perturbative physics and supersymmetry breaking' in the context of a Seventh Framework call.

assistant: **Objectives**

This project is concerned with the characterization of the physics associated with the moduli stabilization and supersymmetry breaking at a TeV scale in String Theory compactifications. Although a lot of progress has been made, a complete picture of the low energy physics of String Theory is still far from being achieved. We plan to improve our understanding of several unexplored aspects which may help to establish a possible link with the experiments. Concretely, we propose to research the phenomenological properties of the recently discovered generalized structures. These turn out to be the natural objects for compactifying the theory to four dimensions, generalizing the Calabi-Yau case, and constituting a perfect framework for flux compactifications. We want to engineer the non-supersymmetric deformations and to identify the patterns of soft supersymmetry breaking arising at low energies. This also involves a better understanding of the non-perturbative physics induced by stringy instantons, and how these could affect the perturbative physics. The deepening into these issues is clearly related to some of the most pressing problems in String Theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a Portable High Energy Nanofocus Computed Tomography system for Glass Reinforced Plastic Wind Turbine Blades' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

A novel portable Nanofocus Computed Tomography PCT system will be developed to perform total structural integrity inspection of present and next generation composite wind turbine blades without taking them out of service. The COncEPT system will provide the only means of detecting significant defects including nanowidth disbonds in the thickest sections of the 100m length blades intended in the future. As a diagnostic tool to assure the safe operation of present and future wind farms it will provide the key enabling technology to support the growth of wind power intended under global economic environmental and societal policy initiatives. Continued increase in the size of turbine blades necessary to meet power generation efficiency targets for wind power may produce enhanced environmental fatigue and impact damage effects of an order as yet unknown and the highest sensitivity of structural health monitoring as provide by COncEPT will be required to address this. The use of WTs has increased at approximately 30 per annum from 1993 and this is set to continue until 2010 consistent with world wide initiatives for sustainable and renewable energy sources. Composite materials are essential to realise these targets efficiently.However a small discontinuity in a composite material can seriously impair its in service function and may lead to a critical fault with little or no visible sign. Failure to detect such a fault can and has resulted in catastrophic failure endangering life and reducing public confidence leading to restricted future WT developments. The need to detect such small defects in the thickest sections of wind turbine blades is only feasible by means of radiography with a nanofucus tube and CT image reconstruction routine. The project will increase the competiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards non-invasive and cost-effective digital twin solutions for cardiac electromechanics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cardiac digital twinning is emerging as a cornerstone of precision cardiology, creating patient-specific digital replicas of the heart that integrate anatomy and electromechanical function. These cardiac digital twins (CDTs) promise personalised therapy and improved outcomes. However, current CDT technologies depend on high-quality imaging and electrocardiographic data, limiting their applicability to a small subset of cases.Cardiorama aims to revolutionise CDTs by enabling anatomical and functional twinning using standard echocardiography (echo) and electrocardiography (ECG). These first-line diagnostic tools are routinely acquired, cost-effective and widely accessible. Echo provides insights into cardiac anatomy and mechanics, while ECG captures the electrical signature of cardiac activation. By leveraging the intrinsic link between electrical activation and mechanical function, combining echo and ECG offers a deeper, synergistic understanding of electromechanical function than either modality alone.The main challenges of low resolution and spatial sparsity of echo-ECG data will be addressed through generative shape models for anatomy and advanced cardiac modelling for functionalization. Robust uncertainty quantification will provide confidence intervals for model calibration, ensuring reliability and identifying limitations in sparse-data conditions. The developed technology will be applied to two clinical challenges: scar delineation in chronic myocardial infarction and the reconstruction of electrical activation patterns in conduction disorders.Cardiorama aspires to democratise precision cardiology by creating a fast, affordable, and clinically applicable CDT solution, accessible even in low-resource settings, enabling earlier and more effective treatment of cardio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ultrasensitive Nano-Optomechanical Sensors' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

By enabling the conversion of forces into measurable displacements, mechanical oscillators have always played a central role in experimental physics. Recent developments in the PI group demonstrated the possibility to realize ultrasensitive and vectorial force field sensing by using suspended SiC nanowires and optical readout of their transverse vibrations. Astonishing sensitivities were obtained at room and dilution temperatures, at the Atto- Zepto-newton level, for which the electron-electron interaction becomes detectable at 100µm. The goal of the project is to push forward those ultrasensitive nano-optomechanical force sensors, to realize even more challenging explorations of novel fundamental interactions at the quantum-classical interface. We will develop universal advanced sensing protocols to explore the vectorial structure of fundamental optical, electrostatic or magnetic interactions, and investigate Casimir force fields above nanostructured surfaces, in geometries where it was recently predicted to become repulsive. The second research axis is the one of cavity nano-optomechanics: inserting the ultrasensitive nanowire in a high finesse optical microcavity should enhance the light-nanowire interaction up to the point where a single cavity photon can displace the nanowire by more than its zero point quantum fluctuations. We will investigate this so-called ultrastrong optomechanical coupling regime, and further explore novel regimes in cavity optomechanics, where optical non-linearities at the single photon level become accessible.  The last part is dedicated to the exploration of hybrid qubit-mechanical systems, in which nanowire vibrations are magnetically coupled to the spin of a single Nitrogen Vacancy defect in diamond. We will focus on the exploration of s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Extracting Super-Resolution from Classical Fluorescence Microscopy' under Horizon 2020.

assistant: **Concept**

The beginning of this century has seen the development of optical super-resolution fluorescence microscopic methods, which yield pictures to resolutions of a few tens of nanometers. This breakthrough has transformed the field of cellular biology, but relies on approaches generally demanding in terms of optics, and which can be applied only on limited classes of fluorophores. This project aims at preparing the commercialization of a new, simple, and cheap, way of extracting super-resolution from images obtained with classical confocal fluorescence microscopes. Currently, this approach yields images with a resolution between 80 nm to 50 nm, which can most likely be increased in a near future. This method can thus be used with any type of fluorophore, just by equipping (confocal) microscopes with a high-end X-Y table and a 2D detector. More complex super-resolution fluorescence microscopic techniques have generated more than 7000 citations in the last years, mostly in biology, but also in chemistry and material sciences. The proposed technology, which can i) easily be implemented for a limited cost and ii) requires no more maintenance and alignment than classical confocal microscopy, is expected to be rapidly implemented in a very large number of laboratories, thus generating new knowledge and a vast range of scientific advances. In the frame of this project, which is a direct consequence of the work started in the frame of the PhotProt ERC advanced grant (id n° 267333), we will in parallel i) improve the performances of this technology by modifying its present design, ii) perform the necessary patenting of this technology, iii) start market studies to evaluate its actual commercial potential iv) enter in contact with companies devoted to microscope engineering and develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CryoEM studies of the spliceosome' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The protein coding sequences of the majority of eukaryotic genes are interrupted by non-coding introns. The spliceosome is an immense and intricate molecular machine that catalyses the excision of introns from pre-mRNAs and splicing together of exons to produce mature mRNA. This is a crucial process in eukaryotic gene expression and we aims to greatly increase our understanding of its molecular mechanism through cryoEM studies of the spliceosome. The spliceosome comprises five canonical subunits, namely U1, U2, U4, U5 and U6 small nuclear ribonucleoprotein particles (snRNPs) and numerous non-snRNP factors. During the initial stages, U1 and U2 snRNPs bind the 5’-splice site and branch point of pre-mRNA, respectively, and the spliceosome is fully assembled when the U4/U6.U5 tri-snRNP is recruited. The spliceosome then becomes activated through extensive structural and compositional remodeling which leads to the formation of the catalytic RNA core. Recently we determined the crystal structure of U1 snRNP and two key spliceosomal proteins: Prp8, which harbours the catalytic RNA core and Brr2, which catalyses the rearrangement of the RNA interaction network and plays a crucial role in spliceosomal activation.  We also solved the structure of U4/U6.U5 tri-snRNP by cryoEM and revealed the nearly complete organisation of U5 snRNA and U4/U6 snRNA and over 30 proteins within this complex, providing crucial insights into the activation mechanism and the active site of the spliceosome. Building on these achievements we aim to determine the structure of the entire spliceosome stalled at different steps of the splicing reaction so that the molecular mechanism of pre-mRNA splicing is understood in structural terms. This will enormously increase our understanding of this fundamental pr