RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TELEMATICS FOR INTEGRATED CLIENT CENTRED COMMUNITY CARE' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

ITHACA aims to improve the quality of care provided to people living in the community through the development of telematics which support the sharing of information between those providing health and social care. The emphasis will be on support for assessment, care planning and delivery of care to the elderly, the mentally ill and for maternal and child health. Greater effectiveness of services will be achieved through the use of integrated technologies and analysis of data held within the database. There will be active participation of users throughout all stages of the project.The aim of ITHACA is to improve the quality of care provided to vulnerable people living in the community though the integration and validation of telematics services, capable of supporting the sharing of relevant information between health and social care professionals.The project will:- Validate and exploit the results of the European Prototype for Integrated Care (EPIC) project (a successful third framework project which developed telematic support for assessment and care planning for the elderly with integration of home telecare and shared antenatal care) within pilot sites with different primary care systems.- To validate the generic concepts and components developed in EPIC across other client groups, in particular those held within a client centred database.- To extend the functionality of the system to enhance its capability to improve efficiency and effectiveness of services through integration of existing technologies and through analysis of the information held within a client centred database.ITHACA will continue the work of developing a generic community information system by further validation of the elderly and antenatal applications in combination with new applications for mental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative bio-based pesticides  to minimize chemical residue risk on food' (INNOVA) under Seventh Framework.

assistant: **Objectives**

Chemical pesticides have significantly contributed to increase productivity and quality of produce worldwide. The risk of losing production because of pests/diseases damages is strongly perceived by growers, who consequently tend to minimize it by using chemical pesticides. On the other hand, consumers are more and more concerned about pesticides. There is a strong need for innovative products from natural origin, safe for humans and the environment, renewable and with a fast biodegradation on the crops in order to minimize residues on food. These products are especially important in those crops where the harvest time is long and plant protection is needed during it. One of the main bottlenecks in developing these products is represented by the poor overlapping and integration between public research institutes and private companies, the first mainly focusing at the production of fundamental scientific knowledge, the latter specialized in the production, formulation and selling of products. The main aim of this Transfer of Knowledge proposal is to reach a better integration between public research and private sector by a close collaboration trough secondments. The main specific objectives are the identification of innovative biopesticides to help growers to produce pesticide residues-free food focusing on the most critical crops and growing stages and to select the potential biopesticides according their intrinsic technological qualities; the development of suitable formulations of the innovative biopesticides; the deepening of the research on some specific aspects requested for the registration and the identification of the best application strategies in IPM and the suitable market strategies. Registered commercial biopesticides are foreseen as final result.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Uncovering the Proteomic Radial organization within the Eukaryotic Nucleus' (PRUNE).

assistant: **Concept**

Recent evidence gathered in the Bienko Lab indicates that, in addition to DNA, many nuclear proteins including several transcription factors implicated in cell fate determination are non-randomly radially distributed in the nucleus of mammalian cells. This fascinating observation led me to hypothesize that there exist a broad set of nuclear proteins that are arranged along radial gradients in the nucleus, acting as readers of the radial genome architecture. Within this MSCA Postdoctoral Fellowship, I aim at tackling this exciting hypothesis by addressing the following fundamental questions: (i) How are nuclear proteins radially arranged in the nucleus of cells undergoing differentiation towards opposing lineages? (ii) What drives and maintains different radial patterns of proteins in the nucleus? (iii) Is the radial arrangement of proteins in the nucleus functionally relevant? To address these central questions I will first develop an innovative tool to map the spatial arrangement of nuclear proteins radially. I will then apply the newly developed method to chart the radial nuclear proteome in human induced pluripotent stem cells (iPSCs) undergoing differentiation towards different lineages. Finally I will explore the functional implications of the radial organization of nuclear proteins by attempting to rewire nuclear radiality and assessing the effects on gene expression and cell identity. This clearly interdisciplinary project aims at finding an explanation in the spatial organization of the genome and the nuclear proteome to a key question arising from cell and developmental biology: how lineage-specific gene expression programs are set up? With this ambitious proposal I will dive into the exciting field of 3D genome organization while addressing a completely new hy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-resolution magnetotelluric imaging' (1998-2002).

assistant: **Concept**

The research project is on the high-resolution magnetotelluric (MT) imaging of complex geological structures. MT is increasingly used in many domains of earth sciences (environment, mining and oil industry; crustal and mantle studies) and 3-D interpretation of data is more and more required. For this project, I want to extend my experience in 3-D modeling acquired during my PhD thesis to high-resolution MT interpretation of dense arrays of data. During the project, I will learn the parallel computing and will use this knowledge to develop a modeling code derived from my original work. The parallelised 3-D modeling code will be applied to the interpretation of a new dense array of MT data acquired during the project. The chosen experiment site is in the north of the Isle of Skye. The structures in the Isle of Skye are typical of volcanic margins and constitute a good analog: Sedimentary basins were deformed by tectonic activity and covered by thick lava flows. These structures are a well-known problem in seismic prospecting since the lava flows reflect the seismic signals, masking the characteristics of the underlying sedimentary structures. The MT method is ideally suited to the imaging of the underlying structures since the MT sounding technique is highly sensitive to the electrically conductive underlying sediments. A model of the Isle of Skye area will allow a better understanding of the structural evolution of the volcanic margins, which interests the scientific community, but also industry because of the potential hydrocarbon reservoirs in such geological context.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Crowded ENvironments moniToring for Activity Understanding and Recognition' (CENTAUR).

assistant: **Innovation**

We aim to develop a network of scientific excellence addressing research topics in computer vision and advancing the state of the art in video surveillance. The cross fertilization of ideas and technology between academia, research institutions and industry will lay the foundations to new methodologies and commercial solutions for monitoring crowded scenes. Research activities will be driven by specific sets of scenarios, requirements and datasets that reflect security operators’ needs for guaranteeing the safety of EU citizens. CENTAUR gives a unique opportunity to academia to be exposed to real life dataset, while enabling the validation of state-of-the-art video surveillance methodology developed at academia on data that illustrate real operational scenarios. The research agenda is motivated by ongoing advanced research activities in the participating entities. With Honeywell as a multi-industry partner, with security technologies developed and deployed in both its Automation and Control Solutions and Aerospace businesses, we have multiple global channels to exploit the developed technologies. With Neovison as a SME, we address small fast paced local markets, where the quick assimilation of new technologies is crucial. Three thrusts identified will enable the monitoring of crowded scenes, each led by an academic partner in collaboration with scientists from Honeywell: a) multi camera, multicoverage tracking of objects of interest, b) Anomaly detection and fusion of multimodal sensors, c) activity recognition and behavior analysis in crowded environments. We expect a long term impact on the field of video surveillance by: contributions to the state-of-the-art in the field, dissemination of results within the scientific and practitioners community, and establishing lon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Peer effects and endogenous network formation' (PEERS) under Horizon 2020.

assistant: **Objectives**

The aim of this project is to develop a theoretical and empirical framework to simultaneously study network formation and peer effects in education. The problem is important from a methodological perspective, as there do not exist general purpose estimatable models of social dynamics in Economics which treat the network formation process as endogenous and simultaneously contemplate network effects on behaviour and its feedback on the network formation process. The possibility of understanding the formation of social networks in terms of the characteristics of the agents forming links is severely limited in most applications by the presence of peer effects that alter these characteristics. Conversely one of the main difficulties in measuring peer effects in any context is that peer groups are endogenous. This project will have two main components (1) a theoretical component and (2) an empirical/experimental component. The theoretical component aims to construct and study in detail the properties of   some models of peer effects treating network formation endogenously. In the empirical/experimental component I will estimate and test the models by (a) Relying on two datasets, one of which already exists and one of which is under construction, and which I am currently using on two related projects and (b)  Building  a detailed longitudinal dataset including information on social network structure and various kinds of behaviours and attitudes using surveys and economic experiments .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Recycling Thermoset Composites of the SST' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The goal of this project is to set up a new route to recycle composites, which will decrease the cost of production waste disposal by 50%. The whole composites sector is now aware of the environmental rules about wastes from composites production (directive on End-of-life Vehicles 2000/53/EC or directive 2002/96/EC on Waste Electrical and Electronic Equipment) which apply to their industry. The routes currently available are expensive and do not give the best use of the wastes, since they are mainly burnt. The heat generated by the combustion process, and the ashes in cement furnaces, are the main, low value, returns. End products given by grinding reused in resins and polymers usually give bad quality products. The consortium believes that it is possible to get a better route if the organic phase is converted to ‘small’ molecules which can be used by the chemical industry and if the mineral phases can be used again in composites. The community wants to define the best conditions in order to obtain a physico-chemical (solvolysis) separation of the different components of the composite and to get the best commercial added value from the end products. In addition, to improve the general standard of competitiveness of the European composite community by reducing the waste management cost, the process will help the composite industry to comply with European regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tuning Immune T cells for cancer therapy' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Adoptive cell therapy (ACT) recently became an important treatment modality for cancer . Since 2017, several chimeric antigen receptor (CAR)-T cell therapies approved by the FDA/EMA and more are expected to receive approval for clinical use. Currently, more than 250 clinical ACT trials are ongoing. Already in 2021, the market size was >$1 billion and is expected to  grow tremendously to >$25 billion  by 2030. ACT products require extensive ex vivo manipulation and expansion of patient derived T cells prior to reinfusion back into patients to attack cancer cells. Unfortunately, T cell exhaustion and loss of function after reinfusion form a major problem in currently used ex vivo expansion protocols.The solution. Dedicated tuning of T cells during ex vivo expansion to preserve their anti- cancer function and prevent exhaustion. In the body, T cells are activated by antigen presenting cells (APC) to initiate an immune response. As patient-derived APC are often immunosuppressed, much effort is spent on developing 'artificial antigen presenting cells' (aAPC) to expand immune cells for ACT. We developed a unique polymeric aAPC platform, termed immunofilaments, that provide a highly flexible-, scalable-, GMP compliant- and affordable- solution for robust production of T cells for ACT. Our initial findings indeed indicate that we can diminish T cell exhaustion and outcompete products currently used in the clinic for ex vivo T cell expansion.Tune-IT will validate the technical and commercial feasibility of this novel technology platform that exploits immunofilaments to significantly improve function and longevity of ACT products in patients. In Tune-IT, we will: 1) demonstrate that tuning of ex vivo cultured therapeutic T cells will prevent exhaustion and loss of tumor killing c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'X5 bitworker - The Copying System for the Internet of Things and Industry 4.0', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The software of products plays a more and more increasing role. It is placed on different types of data carriers (e.g. USB, Compact Flash, SD Card) which are assembled in each of these products (e.g. car infotainment system, washing machine, toys). Digitalisation provides opportunities like customisation and interconnectivity and is basis for applications in Internet of Things and Industry 4.0, but also opens up huge security leaks. The X5 solution secures the product software and its know how and protects them from data theft and hacking attacks.In the past 2 years, X-Net developed the globally unique solution named X5 to assemble customised software on each product for its key customers BOSCH and NOVOMATIC. This enabled in-house and in-line production and individualisation of product software. But most of all it additionally helps to protect European product software (where today most of the know how is based) through unique encryption.The reference installations at BOSCH and NOVOMATIC demonstrate requirements, impact and potential of a fully integrated production with worldwide highest security level. The know how X-Net gained through that is very important for other European and global companies, too. SME instruments should help to build up the market for this solution and bring the expertise to these companies having high needs. X-Net will roll out the X5 solution in Europe and further on globally. Yearly revenues of about 14 million EUR in 2019 and 78 million EUR in 2021 are expected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Systems Analysis of Plant Metabolism through the Integration of Heterogeneous Data from Genetics, Informatics and Metabolomics' in the context of a Seventh Framework call.

assistant: **Objectives**

The term METABOLISM describes all the chemical reactions and interactions that take place in a biological system. The regulation of metabolic pathways is constantly tuned in order to suit the needs of development and fitness. The main goal of the proposed research is to unravel networks of genes and proteins which coordinate the activity of metabolic pathways during plant development and stress response. In Phase I of the project, an infrastructure will be set-up that includes metabolite analyses technologies, a large tomato mutant population and a collection of tomato transcription factor genes. In Phase II, the population will be screened for novel mutants and genes associated with the research interests of the lab. The screens will include: a) visual screening, b) HTP, non laborious assays, c) non-targeted metabolite analysis for the detection of differential metabolites using LC-MS, and d) screening by a reverse genetic approach (from sequence to mutant) through transposon display. The collection of transcription factors will be used for rapid gene function analysis by means of Virus Induced Gene silencing (VIGS), and for the generation of a tomato transcription factors ""Interactome"" map. In Phase III, selected genes and mutants will be subjected to a detailed characterization including: a) the regulatory networks controlling fruit development, b) the regulation of metabolic pathways associated with plant surface metabolism and c) the regulation of the Isoprenoid pathway (including the glycoalkaloids and carotenoids). Data gathered from diverse platforms and screens will be integrated using computational tools to provide new knowledge on the genetic control of metabolic pathways that is currently very limited. This research addresses a major challenge, namely, the