RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'UnRaveling the molEcular baSis Promoting Candidatus BrocadIa as the doMinant anaMOX genus in wastewater treatment plants'.

assistant: **Concept**

The finding of anammox bacteria brought up the possibility of achieving energy-self-sufficient wastewater treatment plants for nitrogen removal, but their widespread technological application is still under research. The lack of pure cultures, standard cultivation methods and comprehensive genetic data make the molecular research on anammox bacteria challenging, and thus, there is a critical absence of molecular studies to understand how these bacteria make a living. One of the current challenges of anammox bacteria research is to understand niche differentiation, meaning how and why different anammox species find their unique ecological space. RESPIMMOX project aims to understand the biomolecular characteristics of anammox Ca. Brocadia that trigger their niche differentiation as the main anammox genus present in wastewater treatment plants, to improve the efficiency and stability of bioreactors. We will obtain biochemical evidence of the membrane-bound protein complexes involved in the electron transport chain of Brocadia-species, and investigate the soluble yet-unidentified enzymes responsible of the nitrite reduction. We will follow a complexome profiling approach combined with enzymatic activity assays, as commonly performed with Dehalococcoides mccartyi in the host laboratory. RESPIMMOX project will be accomplished through three specific objectives: i) achievement of an anammox Brocadia-enriched culture with high cell concentrations; ii) training of the researcher in biochemical methods to characterize respiratory complexes using the respiration with halogenated aromatic compounds as an example; and iii) identification and characterization of the protein complexes involved in the anammox Ca. Brocadia energy metabolism. The results from this proposal will entail a s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of new non-empirical DFT functionals'.

assistant: **Innovation**

Nowadays the application of computational chemistry extends to the realm of bioinorganic, organic and nanotechnology molecules, whose size impedes the use of purely ab initio methods, leaving density functional theory (DFT) as the only recourse to model chemical reactions. The accuracy of DFT calculations depends critically on the quality of functionals used and, as a result, in the last years there has been a craving for new density functionals. Many functionals have been designed, often based on the parameterization of existing ones. While this research brings accurate functionals for very particular purposes, it does not pave the way for long-lasting all-purpose ones. A universal functional should be constructed from physical constraints or model systems, which cover a wide range of molecular situations.Harmonium, a model system alike to an ordinary atom, permits an easy tuning of electron correlation effects, thus being a formidable test bed for DFT methods. The researcher has designed an algorithm to calculate highly accurate energies and wavefunctions of few-electron harmonium systems, which are used to calibrate a large number of DFT functionals. From the benchmark calculations obtained from few-electron harmonium he will design a new version of Müller's functional driven by the amount of electron-correlation introduced in the system. He will also construct a non-empirical DFT functional by imposing appropriate physical constraints. Finally, in order to improve the performance of the functional a hybridized form of latter will be constructed. The designed DFT functionals will not be just an evolution of the current ones, but a new type. Thus, they could solve some of the critical problems of the current functionals.There are very few groups in Spain working in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TOWARDS THE ESTABLISHMENT OF A FRAMEWORK IN MALARIA BETWEEN THE AMRN  AND EVIMALAR', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

54 partners from 34 institutes have formed an EC-funded Network of Excellence (NoE) in basic malaria research, the European Virtual Institute for Malaria Research (EVIMalaR). Over the previous >5 years as the NoE Biomalpar these partners successfully broke down many barriers to cooperation pursuing a programme of integrated research. This was greatly assisted by the Biomalpar PhD School whose students were supervised by two partners from different member states. Evimalar represents the latest incarnation of this network and has recruited in tranches 21 students into the Evimalar PhD School. Australian malaria researchers have also realised the greater benefits of collaborative research and within the Australian Parasitology Network have exchanged personnel and expertise. Both the European and Australian networks recognised that their domestic spirit of cooperation could be mutualised and signed a Memorandum of Understanding (MoU) in 2007 (updated in 2010) to formalise the ambition. The MoU generated greater exchange between the regions but was limited due to lack of finance. Evimalar created a legal link between the regions by incorporating an Australian malaria researcher who was then applied for funding from the Australian NHMRC to finance OzEMalaR, a mechanism for exchange of Australians to Evimalar partners. Ozmalnet seeks reciprocal funding to allow Evimalar researchers to conduct exchange visits to OzEMalaR laboratories. Both regions are world leaders in malaria research with particular local strengths that can be exploited to the mutual benefit of both regions and their early stage researchers including Evimalar PhD students who will primarily be undertaking the exchanges. The outcome will be a more globalised integration of malaria research and greater exchange
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Powder Protected Cardan Chain in Industrial Floor Conveyors', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The strategic objective of the project is to make powder coating technology available to a much broader range of industry by developing a novel cardan chain track for floor conveyor system which protects the chain against the paint powder in powder spray cabins and allows for easy spray booth cleaning when colours will be changed This is currently not possible due to the geometrics and electrostatically earthed situation of standard chain floor conveyors. The aim of this project is to develop a novel chain floor conveyor system for powder application. CFC systems consist of a chain track with an integrated cardan chain running through the track. The chain in some cases also is equipped with pusher dogs into which the anchor of the carrier is hooked. The chain transports the loaded carrier throughout the entire production line.The PROTECC system to be developed will be totally new and special track, which will be de-signed as following: - Double skinned track to implement a wind curtain protection - Application of an electrically load to the track to stop powder sticking to the track - Outer skin of the double skinned track made of a not metallic material to avoid powder sticking to the track The prime industrial / economic objectives of the PROTECC project are: - Development of a novel technique that will enable the replacement of traditional liquid painting technology by a more environmentally friendly one - Up to 95 % recovery of the overspray powder for reuse - Increased productivity due to reduction of costs inherent to the replacement of liquid coating technology (i.e. less waste disposal cost) - Rapide (< 15 min) change of colours possible - Design of a flexible system especially affordable for SMEs...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A Total Photon Camera for Molecular Imaging of Live Cells'.

assistant: **Concept**

How can we construct a high-resolution camera capable of imaging the time-of-arrival, polarisation and wavelength of each of the maximal 10Gphoton/s emitted from a labelled, biological cell?Such a measurement would capture the complete information available in the optical signal, and significantly enhance our ability to observe the organisation, movement and interactions of cellular components at molecular scales. Advances in single molecule light microscopy are steadily improving our understanding of the processes underlying normal cellular function, and their alteration in disease states. However, these technologies are unable to reach their full potential due to their reliance on pre-existing, suboptimal detectors. A dedicated camera technology is now required to permit simultaneous, multidimensional measurements of large cohorts of molecules at high temporal and spatial (sub-diffraction limit) scales through total imaging of the photon flux.Today’s digital cameras capture photons in packets of 10-100 thousand and provide them for external display or recording at fraction of second intervals. In order to process photons individually rather than as packets we must develop a camera operating 10-100 thousand times faster. Each pixel must be capable of capturing single photon parameters without compromising the high resolution and sensitivity achieved by current technology.  The ""total photon"" camera will be realised in nanoscale CMOS technology, based on recent breakthroughs in ultra-miniature single-photon detectors. We will combine these with novel approaches to pixel circuits, image processing and high-speed readout electronics to provide a fundamental research tool for the emerging area of computational microscopy. We will provide access to the full record of phot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Data driven approach for a Seamless Efficient European Travelling in 2050'.

assistant: **Innovation**

DATASET2050 (DATA driven approach for a Seamless Efficient Travelling in 2050) is the very first Coordination and Support Action that - through a cutting edge data science approach - will provide insight into the door-to-door European travel paradigm for the current, 2035 and 2050 transport scenarios.DATASET2050 puts the passenger at the centre, paving the way for a seamless, efficient door-to-door travelling experience. The main focus will be put on analysing how the European transport supply profile (capacity, connections, business models, regulations, intermodality, processes, infrastructure) could adapt to the evolution of the demand profile (customers, demographics, passenger expectations, requirements).Through expert application of state-of-art predictive analytics, modelling, statistical analyses and data visualisation, with an examination of multimodal data, these analyses will enable the identification of European transport bottlenecks and weak areas across the different scenarios. These findings will serve as a basis for the development of intermodal transport concepts, identifying possible solutions for current and predicted shortcomings. The insights gained through the project's approach will highlight research needs towards the four hour door-to-door goal formulated by ACARE.Given the nature and aim of the initiative, the DATASET2050 partners and Advisory Board are comprised of top European transport Entities (universities, policy makers, industry, research Institutes, GIS and inter-/multimodal entities) with major inputs into European strategy agendas. A comprehensive dissemination and communication plan will ensure efficient circulation of the results among key European transport policy makers and stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MICRO-MECHANICAL PUMP FOR NEXT GENERATION INSULIN DELIVERY SYSTEMS'.

assistant: **Objectives**

PRISMA is a revolutionary thin-film micropump realized with novel ceria-based oxides actuating materials in the frame of the FET-OPEN BioWings project, which can be used as an innovative pumping system in wearable insulin delivery devices for the treatment of diabetes. The integration of the PRISMA micropump in insulin patch pumps addresses the 3 most important pain points that still keep the vast majority of diabetic patients away from this life-saving treatment:1) Size, which is more than two orders of magnitude smaller than state of the art.2) Higher drug delivery accuracy within the ?5% range ensures the highest therapeutic efficacy.3) drastic reduction in energy consumption.Besides the short-term vision to realise extremely compact and accurate patch pumps, the long term goal is to allow the realisation of multi-drug delivery systems, making real the much-lauded multi-hormone treatment.The main objective of this project is to validate the pump and its manufacturing process in a real operating environment, proving to system integrators that all specifications are consistently met to pave the way for the post-project system integration and clinical validation. This will pave the way to the launch of a startup company that will take care of the final steps of the development roadmap and will establish long-term cooperation agreements with prominent medical device manufacturers for the integration of PRISMA in next-generation single and multi-hormone smart patches.


**Keywords:** Microcapillary Pump, Actuators, Electrostriction, Cerium Oxide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Methodology and tools for multimedia documentation and electronic catalogues' under Fourth Framework.

assistant: **Concept**

The project aims to provide an integrated methodology and toolset for the development of multimedia-based technical documentation and electronic publishing. //PJ_PJ_SIP Multimedia retrieval; multimedia database management system; electronic publishing; technical documentationA market study carried out by the IAO has shown that there is a lot of software in this field but only a few packages are well-integrated, especially with regard to the integration of multimedia. The major findings from the study are that: there is a lack of transparency in the market for technical documentation; there is a strong need for the integration of multimedia elements into electronic publishing (e.g. videos of complex repair processes in electronic service manuals); currently available technical documentation (including catalogues, brochures, manuals, etc.) is not of sufficiently high quality; user access mechanisms have to be improved; time and costs in the production processes are too high; keeping consistency in the updating processes is a problem. The solution to these problems is to develop an integrated system that fulfils the following objectives: development of a toolset of components for technical documentation and electronic publishing that integrates available tools in a user-friendly and homogenous environment; use of a methodology for the whole process of production that leads to automation of the development of technical documentation; innovative, high-quality user access and retrieval mechanisms; making the content digital as early as possible and keeping it digital as long as possible. The METODOC project takes a user-driven approach. The iterative development of the components will be strongly influenced by detailed user specifications. Moreover, three pilot applications w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Object recognition integrating active vision and self-organising neural networks' (1994-1998).

assistant: **Innovation**

The classical approach to artificial intelligence in vision, has faced many fundamental problems. Progress was made in very specific and strictly-controlled application domains only. On the other hand, during recent years a tremendous amount of new biological evidence has been brought about by visual neuroscience which could be used for developing artificial vision systems. This project proposes a new 3D object recognition system that will reconcile state-of-the-art computer vision techniques with neurobiological and psychophysical evidence of visual perception. Active vision, i.e. including intentional observer motion in the visual process, will be implemented based on locally-autonomous and self-organising brain-style neural networks. The aim of this project is to realise a working system which can recognize many (i.e. more than 100) types of natural or everyday 3D-objects, in a way which is invariant to changes in the presentation of the objects or to the presence of structural noise in the input.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Production and characterization of endocrine cells derived from human pancreas organoids for the cell-based therapy of type 1 diabetes' (LSFM4LIFE), addressing dissemination and exploitation.

assistant: **Impact**

Self-renew and multilineage potential characterize stem cells.  We have recently described that pancreas progenitor cells extracted from adult donors can be expanded long-term in vitro into 3D structures, which we have termed organoids.  Pancreas organoids reproduce in vitro all the features of pancreas ductal epithelia, and have a limitless expansion potential.  Thus, pancreas organoids promise to boost cell therapy of type 1 diabetes.  We have recently observed that progenitor cells organoids preserve their genetic stability over a long time in culture. That represents an advantage, when compared to iPS or hES derived approaches, where genetic instability raises concerns for their future therapeutic applications.  While progenitor organoids are promising for the future of cell therapy, bringing stem cell-based therapies to patients requires a reliable characterization (“knowing what the cells do and how they do it”, i.e. a phenotypic and molecular biology characterization), chemically well-defined culture media, and the capacity of mass-production under GLP/GMP conditions.The LSFM4LIFE consortium aims to the mass production of pancreas organoids for the cellular therapy of type 1 diabetes.  The goals of the project are: (1) optimize growth and differentiation of human pancreas stem-cell organoids by employing phenotypic and molecular high-throughput screening (2) standardize the growth and differentiation of the organoids under well-defined biochemical conditions, and (3) achieve GLP/GMP-production of the human organoids for preclinical studies and phase I clinical studies.  The close collaboration in the consortium between academic researchers and industry, as well as its cross-disciplinary composition, are essential to realize the goals of the project.  The work pac