RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genetic prostate cancer variants as biomarkers of disease progression' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Prostate cancer is the most common cancer in males in Europe, causing over 87,000 deaths in 2006. Early diagnosis and treatment are key factors in determining survival but screening methods based on the commonly-used PSA blood test have low specificity and result in excessive treatment of localized lesions that might never progress to symptomatic cancer. Biomarkers that help determine which of the early stage tumors will remain confined to the prostate and which will progress to an invasive, aggressive form of the disease are urgently needed. Using genome-wide association analysis, we identified 4 distinct common genetic variants that increase the risk of prostate cancer, some of which may have a stronger association with severe disease. Furthermore, by comparing the genotypes of patients with aggressive disease to genotypes of those with a more indolent form, we have identified a large number of candiate markers of disease severity. Here, we plan to take all these inherited variants and test the hypothesis that they can serve as biomarkers for prostate cancer prognosis and outcome. In addition, we have selected two of these variants for genomic and functional studies.   Specifically, we will 1.   Collect DNA and clinical data from over 8000 prostate cancer cases in four European populations (Iceland, the Netherlands, Romania, UK) 2.   Test the utility of inherited prostate cancer risk variants as biomarkers of disease severity, progression and outcome   3.   Start dissecting the biological mechanisms that cause increased prostate cancer risk   The expected outcome of the project is  a) A new prognostic test that predicts clinical outcomes for localized prostate cancer more accurately than existing methods.   b) Documentation of the association of genetic risk variants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulating Vehicle Access for improved Livability' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite urgent calls for “smarter urban vehicle access regulations” in the Urban Mobility Package and other high-level political commitments, very few decision makers are keen on going public with the idea of restricting car access (in time or space) in urban areas. ReVeAL will help to add Urban Vehicle Access Regulations (UVAR) to the standard range of urban mobility transition approaches of cities across Europe. Toward this end, the ReVeAL consortium will combine conceptual work and case study research with hands-on UVAR implementation in six pilot cities and systematic stakeholder interaction and professional communication activities. The pilot cities of Helmond, Jerusalem, London, Padova, Vitoria-Gasteiz and the project leader Bielefeld are committed to developing, implementing, testing and evaluating UVAR measures in one or more of four “Measure Fields”: 1) Zero Emission Zones, 2) Spatial Interventions, 3) Pricing Measures and – through a process called “sandboxing” – 4) some innovate Future Options (C-ITS, geo-fencing etc.). ReVeAL considers the implementation of UVAR measures a necessary part of a wider transition management challenge and therefore ensures comprehensive and coordinated changes to multiple elements of the urban transport system. Most prominently, these aspects fall into four “Transition Areas”: Governance and Financing; User Needs/Acceptance; Mobility Concepts; and System Design/Technology – all of which play a role in any change process. With its built-in mechanisms to accompany, document and analyse the processes and impacts in the six pilot cities, ReVeAL will be able to systematically extract lessons learned and thus support the wider roll-out of smart UVAR approaches across Europe. A key strategy towards this goal is the provision of practica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Learning From Failing and Passing Executions At the Speed of Internet'.

assistant: **Innovation**

Modern software systems must be extremely flexible and easily adaptable to different user needs and environments. However, this flexibility also introduces relevant quality issues. These problems are so common that is sufficient browsing the Web to find millions of reports about failures observed after updates and incompatibilities caused by the interaction of a newly installed component with the existing components. The impact of problems introduced by end-users can be dramatic because end-users can easily modify applications, like developers do, but end-users have neither the knowledge nor the skill of developers, and they cannot debug and fix the problems that they unintentionally introduce. It is thus necessary to timely develop novel solutions that can increase the reliability of the moderns systems, which can be extended and adapted by end-users, with the capability to automatically address problems that are unknown at development-time.The Learn project aims to produce innovative solutions for the development of systems that can work around the problems introduced by end-users when modifying their applications. The three key elements introduced by Learn to automatically produce a (temporary) fix for the software are: (1) the definition of the InternetLearn infrastructure, which is a network infrastructure that enables communication between every individual instance of a same program running at different end-users’ sites, thus augmenting each application with the capability to access a huge amount of information collected in-the-field from other sites; (2) the definition of analysis techniques that can learn the characteristics of successful and failed runs by monitoring executions in the field from a number of instances running at many end-user sites; and (3) the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ground coupled heat pumps of high technology' (GROUNDHIT) targeting Sixth Framework.

assistant: **Abstract**

The project GROUNDHIT aims at improving cost-effectiveness, competitiveness and market penetration of ground coupled heat pumps. The project involves 16 partners from 11 countries, three of which are new states and a budget of ¿3.644.134 (22,7% R&D, 59,5% Demo and 14,4% Innovation) requesting EU Funding of ¿1.760.832 (48,32%), focusing on the following:- Borehole Heat Exchanger (BHE) Research: Optimisation in terms of heat transfer with the earth, standardization and development of a prefabricated prototype, resulting in advanced vertical BHE.- Ground coupled heat pumps research focusing on the theoretical design and laboratory experimentation: Optimisation of ground source heat pumps (electrical water source heat pumps intended to be used together with a borehole heat exchanger) in terms of COP. We anticipate to increase the energy efficiency of such heat pumps from maximum COP-4,5 to COP>5,5 and the corresponding SPF from 3,9 to over 4,5. Development of electrical ground source heat pumps able to deliver 80°C hot water (existing units cannot deliver more than 65°C). Optimisation of electrical water source heat pumps intended to utilize hot groundwater up to 40°C as a heat source in terms of COP. We anticipate raising the energy efficiency of such heat pumps to COP well over 7, depending on the temperature of the input hot water.- Prototypes development and demonstration of the above technologies: Ground source heat pump of COP>5,5, coupled with prefabricated borehole heat exchangers in Portugal. Ground source heat pump delivering 80°C hot water, coupled with prefabricated borehole heat exchangers in Austria. 40°C water source heat pump of COP>7, coupled with a hot water geothermal well in Greece. Demonstration of ground source heat pump of COP>5,5 with the aid of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'A Drosophila in vivo model of the glial repair response'.

assistant: **Innovation**

When central nervous system (CNS) neurons are damaged or lost, e.g. in spinal cord injury, glia over-proliferate leading to spontaneous remyelination and homeostasis maintenance, known as the glial repair response. This repair response is limited, but it reveals a tendency of the CNS to repair itself.This is also manifested during normal development as neuronal and glial populations adjust cell number and axonal patterns to maintain structural CNS robustness. Upon spinal cord injury in mice, transplantation of non-myelinating ensheathing glia to the site of injury is sufficient to repair axonal trajectories and neuronal function. Thus, restoring glial populations may be both necessary and sufficient to promote CNS repair.It is thus a great challenge to harness the glial repair response to implement repair. Little is known of what genes control glial precursor proliferation and differentiation. In mammals, Notch1 maintains glial precursors proliferative and Tumor Necrosis Factor provokes proliferation of glial precursors upon injury.However, finding out whether a common genetic network underlies these observations, and whether they have any relevance for repair in vivo, is extremely challenging in vertebrates. Gene function can be tested in glia in vivo, in time-lapse and with single cell resolution using Drosophila as a model organism. Findings from Drosophila can then be tested in human glial precursors.The applicant has discovered a glial repair-response in Drosophila adults, which depends on the gene eiger, a TNF-superfamily member. The host discovered a glial repair-response in the Drosophila embryo that requires the genes Notch and prospero, which control cell cycle gene expression and maintain glial precursors immature.The aim is to test here whether a universal g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hybrid Electric Regional Aircraft Concept for Low EmissionS' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In a world where the consequences of the climate change are already observable, the reduction of the aviation’s ecological footprint is undoubtedly essential. With 22% of total commercial flight departures being operated by regional aircraft, the introduction of more innovative concepts is necessary to achieving the net-zero carbon emissions by 2050 defined by the European Green Deal.In this context,  HERACLES aims to define an ultra-efficient regional aircraft (UERA) concept, embedding innovative technologies, such as a hybrid electric propulsion system with high-performance batteries and optimized thermal engine (using 100% SAF), optimized propeller, advanced airframe and other enabling technologies for more electric aircraft. This concept targets a reduction of no less than 30% in CO2 emissions on typical regional routes (250NM or below), compared to a 2020 state-of-the-art aircraft.The project will benefit of a portfolio of demonstrations in regional thrust, to integrate technologies at high level of maturation (TRL5/6 at the end of the program), to support entry into service in 2035. The certification aspects will also take a major role in HERACLES. The project will coordinate the EASA involvement in all projects of the consortia (HERACLES, REG-01, REG-02 and REG-03), to contribute to the rulemaking for hybrid aircraft and deliver a route to CRL6. Furthermore, HERACLES will support the flight test demonstrator (FTD) assessment led by the REG-03 project, by providing the architecture and configuration assessment of fully integrated design of the demonstrator and the flight physics studies. It will also support the wind tunnel tests performed in this project by providing the design of the propeller and nacelle concept to be tested. With these activities defined for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Immune mechanisms in Environment-induced brain plasticity: Role of T cell-ILC Crosstalk' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Neuroplasticity is the essential ability of the brain to respond and adapt to extrinsic and intrinsic stimuli, and it is strongly influenced by the environment we live in. Exposure to e nvironmental enrichment (EE)  leads to neurological changes paralleled by changes in the immune system. EE promotes neurogenesis, neuroplasticity, and ameliorates neuroinflammation in both rodents and humans. Microglia and brain T cells also adapt their phenotype and T cell number increases, suggesting a connection between neural activity and immune response. How brain T cells or other lymphoid cells and microglia are able to respond to EE and eventually modify the brain is unknown. I hypothesize that EE instigates a  neuroimmune crosstalk between lymphoid cells and microglia to support the neuronal changes. To test this, I will use high-dimensional spectral flow cytometry and CITE-seq to map the changes in the intercellular communication networks induced by exposure of mice to EE and identify key cellular and molecular mediators. Next, I will combine depletion tools and genetic models to assess the specific role of different subsets of lymphocites in EE-induced brain plasticity. The final ambition of this project is to identify  key molecular targets mediating EE-induced lymphocites-microglia crosstalk. I will then use a gene therapy approach to deliver candidate biologics to the brain. Using a mouse model of Autism, I will provide impactful proof-of-concepts for the ability of immune molecular mediators to stimulate pathways of brain plasticity and mimic the benefits of environmental enrichment in neuropathology.


**Keywords:** Environmental enrichment, Neuroplasticity, Neuroimmune crosstalk, T cells,  Innate Lymphoid Cells(ILCs), Fragile X-Syndrome model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable Approach to Drug Discovery' (SusDrug).

assistant: **Concept**

Modern drug discovery is facing critical challenges. Rapid advances in human biology are revealing new biomolecular targets and processes, for which existing chemical compound libraries can provide only limited success in the identification of novel bioactive agents. This deficiency has been attributed primarily to the relative lack of structural diversity within the libraries. The three-dimensional world of biological macromolecules has been continuously interrogated with generally similar planar, aromatic, and structurally simple compounds. Contemporary diversity-generating methods have never been implemented for the preparation of large libraries, as an increase in the number of diverse members requires a corresponding increase in the number of synthetic steps, or a continuous supply of different staring materials. This proposal details a strategy for developing a chemically sustainable diversification method, by tapping into our largest source of organic compounds: arenes.The proposed research aims to develop new methods that can rapidly convert simple aromatic entities into highly functionalized, complex small molecules. By integration of this strategy with many different chemical operations, numerous distinctive and independent dearomative programs will generate a diverse set of multiplex small molecules. This simplicity-to-complexity approach will provide a practical platform for the rapid, controlled access to a functionally diverse set of compounds, ranging from anticancer to anti-infective agents. This research will also deliver methods for dearomative diversification of existing aromatic compound libraries to provide new members with unique physiochemical properties. Given the broad scope of possible dearomative programs that will be developed, and the vast a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Long-term testing of airtightness to increase energy efficiency in buildings.' (LTT), addressing dissemination and exploitation.

assistant: **Impact**

The LTT Phase 2 project is designed to address and implement the findings of our Feasibility Study and to enable a rapid and successful commercialisation of our Long-term testing of airtightness (LTT) technology.Venturigo has developed the only solution in the market capable of monitoring 24/7 how much air, energy and money are leaking in a given building, and to adjust the ventilation system to reduce this leakage by an average of 50%. LTT has x100 lower upfront cost than alternative solutions in the market for improving airtightness, and a 5.8/6.9 months payback period in high-rise residential buildings and large services buildings, respectively, a major advancement over the current state-of-the-art and our unique selling point (USP). The EC Nearly Zero-Energy Building Strategy 2020 highlights the importance of a sustainable European economy and society based on the efficient use of resources and renewable energy. In this sense, while buildings are now responsible for 40% of energy consumption and 36% of CO2 emissions in the EU, the Energy Performance of Buildings Directive requires all new buildings to be nearly zero-energy by the end of 2020 and all new public buildings by 2018. LTT will help to face these challenges by reducing buildings CO2 emissions by 690,296 tonnes and will offer our clients accumulated energy and cost savings of 1,237 MWh and €203.2m, respectively during the first 5 years of commercialisation according to our 5-years projections.LTT addresses the large and growing market of technologies for improving energy-efficiency in buildings, which is projected to increase from €163.4bn in 2017 to €259.1bn in 2026 attaining a compound annual growth rate (CAGR) of 5.26%. By successfully implementing the LTT project, we expect to create a measurable impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fast and Reliable Symbolic Computation'.

assistant: **Concept**

The use of computers for formulating conjectures, but also for substantiating proof steps, pervades mathematics, even in its most abstract fields. Most computer proofs are produced by symbolic computations, using computer algebra systems. Sadly, these systems suffer from severe, intrinsic flaws, key to their amazing efficiency, but preventing any flavor of post-hoc verification.But can computer algebra become reliable while remaining fast? Bringing a positive answer to this question represents an outstanding scientific challenge per se, which this project aims at solving. Our starting point is that interactive theorem provers are the best tools for representing mathematics in silico. But we intend to disrupt their architecture, shaped by decades of applications in computer science, so as to dramatically enrich their programming features, while remaining compatible with their logical foundations.We will then design a novel generation of mathematical software, based on the firm grounds of modern programming language theory. This environment will feature a new, high-level, performance-oriented programming language, devised for writing efficient and correct code easily, and for serving the frontline of research in computational mathematics. Users will have access to fast implementations, and to powerful proving technologies for verifying any component à la carte, with high productivity. Logic- and computer-based formal proofs will prevent run-time errors, and incorrect mathematical semantics.We will maintain a close, continuous collaboration with interested high-profile mathematicians, on the verification of cutting-edge research results, today beyond the reach of formal proofs. We ambition to empower mathematical journals to install high-quality artifact evaluation, when p