RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Risk-BRidge (Building Robust, Integrative interDisciplinary, Governance Models for Emerging and Existing risks)' (RISKBRIDGE).

assistant: **Innovation**

This proposal aims to develop an integrative risk governance model connecting risk assessment - management and -communication based on a resilience and discursive approach.The project takes:- an open project architecture rather than a specific model as starting point;- policy learning as the central mode of operation, allowing for input across different science fields, geographical boundaries and science-policy interfaces;- cases related to complex risk fields where the agreement of risk government approaches is limited.- An approach with six partners and 30 members (scientists and policymakers)The project is structured in three parts. In a preparatory phase the key partners exchange insights on risk governance practice, and transform this into a framework for risk governance learning. In the empirical work phase, six risk fields take centre stage. It concerns: Biotechnology/stem cells, Radioactive waste, Nanotechnology, Climate change, Sediments and Electromagnetic fields.For each risk field, a learning trajectory will be organized, in which 3 workshops form the focal points. Ws 1 focuses on learning about best practices across disciplines and participants within each risk field. Ws 2 'designs' a best science-policy interface for each risk field. Ws 3 compares, analyses and learns across risk fields resulting in an accepted governance model including transdisciplinary lessons and input from scientists and policy makers.In the integration phase the results from the workshops and risk fields will be combined an integrated in a report (book) recommending how to handle complex and emerging risks in the form of a process scheme approach. The results of the project are validated and disseminated in a conference on Risk governance. A 'Heritage' work package make sure concepts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The first predictive test for radio-sensitivity. A step towards an improved and personalised radiation therapy cancer treatment.'.

assistant: **Concept**

Each year, two out of three cancer patients undergo radiation therapy, meaning close to 1.5M patients in Europe and 2M in the US. However, scientific evidences prove a direct link between radiation therapy and several serious late effects. This because patient’s tolerance to radiation vary significantly and radiotherapy affects indiscriminately both healthy and cancer cells, damaging also active working cells, tissues or organs around the tumour. There is, therefore, an unmet clinical need to tailor treatments to each patient’s unique biology. NovaTests are the first predictive radio-sensitivity tests for cancer treatment. By analysing a simple blood sample, in one week time, we can determine with high accuracy (over 90%) not only whether a patient is sensitive or not to radiation but also how sensitive the patient is. We allow for more efficient treatments and improved quality of cancer survivors, not only during radiation treatments but for the rest of their lives. Our first test, the NovaGray Breast® is aimed at measuring radiosensitivity for breast cancer patients. It meets all regulatory requirements of the 98/79 directive pertaining to the in-vitro diagnostic medical devices, has been stamped with the CE marking in February 2016. So far, €0.5M million have been invested into the development and testing of technology to ensure its robustness and efficiency and move into the next stage of tests development and validation. Within the overall project, we intend to scale-up the process by automating it and run a multi-centre clinical trial to validate the reliability of the test. Further ongoing developments include the extension of the technology to prostate and lung cancers. The proposed work in Phase 1 of the SME instrument fits into our overall plan to reach the ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'NEuromorphic PhoTonics with fast and efficient vertical cavity sUrface emittiNg lasErs'.

assistant: **Innovation**

NEPTUNE aims to develop novel neuromorphic photonic technologies able to both sense and process information in real-time, drawing direct inspiration from the brain’s powerful computational capabilities. Current photonic technologies find applications in sensing, communications, and information processing, including security, environmental monitoring, high-speed fibre-optic and wireless data links. However, sensing and computation functionalities are frequently decoupled, creating bottlenecks in energy and latency. NEPTUNE aims to tackle this critical challenge, addressing the urgent need for compact, low-cost, fast, and efficient photonic platforms that integrate both functionalities in a single hardware framework. NEPTUNE’s platform exploits Vertical-Cavity Surface-Emitting Lasers (VCSELs), widely deployed in our society (in barcode scanners, mobile phones, light sources in optical networks, datacentres, etc.) for their low cost and energy efficiency. These VCSEL systems, operating at multiple infrared wavelengths, will be used to generate complex speckle patterns through optical fibres, acting as light diffusive media. The characteristics of these light patterns are highly sensitive to environmental perturbations (such as temperature, strain, and audio signals) enabling their sensing functionality. Event-based photo-detecting systems, which convert light signals into neural-like spikes, will capture the formed speckle patterns, creating a high-resolution photonic sensing system based on an ultrafast, discrete, neuromorphic data representation. Simultaneously, by generating fast optical neural-like spiking regimes with the VCSELs, we can exploit spike-based encoding mechanisms to represent input data in speckle patterns, embedding further computational capability in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of ‘Less than Wagon Load’ transport solutions in the Antwerp Chemical cluster'.

assistant: **Objectives**

The LessThanWagonLoad project has the objective to develop a smart specialized logistics cluster for the chemical industry in the Port of Antwerp in order to shift transport volumes from road to rail freight. This objective will be realised by developing: (i) a new rail transport solutions for single pallets (we call this LWL ‘less than wagon load’ in analogy with existing LTL ‘less than truck load’ transport) and (ii) new added value rail freight services for the industry within the Antwerp chemical cluster. These potential new services consist of parking, repair, picking and cleaning for chemical wagons, rail connected cross docking of pallets and improved rail connections by setting up mixed trains with conventional and maritime container volumes.The project primarily focuses on Antwerp and the chemical industry. But the new concepts can also be leveraged to other logistical hubs with other industries. This will be demonstrated at a second logistical hub Nola, in the south of Italy. This broad implementation potential increases the impact on European society. Realising the LessThanWagonLoad project will contribute in a substantial way in realizing the EC’s ambition to shift 30% of road freight over 300km to low-emission modes by 2030. The potential benefits of the project  for European society are very important and diverse: (i) environmental improvements (less GHG emissions), (ii) reduced costs of rail freight, (iii) increased inter-modality and higher resilience of the transport system, (iv) local economic growth and employment, (v) less congestion and traffic casualties and (vi) less risk on social dumping.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mathematical modeling of human physiological systems with biomedical applications' under Sixth Framework.

assistant: **Concept**

A series of four events is proposed: each event consists of a school and an associated workshop held at the end of the school with the same theme as the school. These events present key mathematical modelling techniques for application to modelling human bio-medical and clinical problems reflecting control aspects at primarily the organ and system level. Models that are sufficiently detailed to have predictive value typically involve a significant number of parameters, rendering parameter identification difficult. Also, the restricted number of minimally or non-invasively measurable physiological quantities and the highly individualized variation in the relative responses of physiological control mechanisms render clinical application problematic.However, the appearance of new analytic, biometric, and numerical techniques and methods are contributing to making the above complications tractable. Each combined school/workshop event has its own primary mathematical and biomedical focus reflecting aspects of the modelling and clinical issues described above. These events are designed to introduce new researchers to important methods for developing, analysing, and applying mathematical models in several key clinical areas. Each school's associated workshop introduces the school participants to state-of-the-art research in the focus topics of the school, allowing school participants to utilize what they have learned. School courses and workshop presentations will be given by an interdisciplinary array of experts from academia, industry, and the clinical setting.Besides the educational benefit, two other important benefits are sought:(a) creating potential collaborative connections between new and established researchers;(b) promoting a network of researchers in mathematical m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High throughput development platform for oligonucleotide aptamers' (SPARXS).

assistant: **Concept**

The binding kinetics of an affinity probethe speed and duration with which it attaches to a target moleculemust be precisely tuned for numerous applications in therapeutics, super-resolution microscopy, and biochemical assays. The current methods of development lack the capability to specify these binding kinetics during probe design, resulting in the potential for effective drugs and relevant biological properties to remain undiscovered. Here, I introduce a game-changing solution: Single-molecule Parallel Analysis for Rapid eXploration of Sequence space (SPARXS). SPARXS harnesses the power of single-molecule observations and subsequent high-throughput sequencing to simultaneously reveal the binding kinetics and sequences of millions of aptamers (affinity probes composed of nucleic acids). This process enables the tailored design of probes with the desired binding behavior for various applications.This technology originated from my ERC Consolidator Grant project as a research tool, and its application can fulfill multiple practical demands. As SPARXS provides a particularly excellent fit for aptamer development, I have decided to enhance the platform with aptamer-specific features. Furthermore, I will conduct market research to understand the specific demands of users seeking defined-kinetic probes, which will facilitate commercialization of SPARXS-based aptamer design upon completion of the project.In summary, SPARXS signifies a disruptive advancement in aptamer development and will revolutionize affinity probe design across the biotech industry. With minimal adaptations to the core technology, I anticipate a high potential for swift commercialization as a dedicated development platform.


**Keywords:** "High throughput development platform"", ""Oligonucleotide aptamer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scaffold Based Supramolecular Architectures as Protein Epitope Mimetics for Biomedical Applications' under Seventh Framework.

assistant: **Concept**

Synthetic molecules that mimic the structure of the part of a folded protein involved in recognition events (protein epitope mimetics, PEMs) can access biological targets previously deemed as “undruggable” and are considered as a potential source of future therapeutics. So far, PEMs could effectively mimic only individual secondary structure elements of peptides and proteins. The major goal of this project is the development of a novel versatile platform for the design of multifaceted 3D architectures as PEMs of higher order structure elements and discontinuous epitopes of bioactive protein surfaces. The platform is based on cyclic pseudopeptide scaffolds comprising triazole rings linked by conventional amide bonds that are designed to allow for precise topological positioning of biomolecules. The synthetic strategy relies on sequential assembly on solid support of tailor-made building blocks through cycles of alternated amide coupling and Copper(I)-catalyzed azide-alkyne cycloaddition reactions. The building blocks will be prepared in solution and using solid phase synthesis (SPS) to produce macromolecular units bearing bioactive peptide segments. Conclusively, these PEM systems can provide further insight into protein folding mechanism and recognition processes of bioactive protein surfaces. On the other side, improving pharmacodynamic and pharmacokinetic properties of natural peptides and proteins, a number of biomedical applications can be targeted. Specific focus will be devoted to the development of PEM anti-infective agents and the mimicry of structural and functional properties of trimeric HR1 complex of the HIV-1 protein gp41. Moreover, the developed platform can allow for the design of chimeric PEM systems that present saccharide and peptide units in a converg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THz Near-Field Imaging of Unconventional Superconductors' (SUPERTERA).

assistant: **Concept**

Superconducting materials are the heart of the modern quantum technologies including quantum computation with its main workhorse - superconducting qubits, magnetic flux and voltage quantum metrology  with Josephson junctions and superconducting quantum interference devices. Hence the formidable effort to raise the superconducting transition temperature by researching new materials and superconductivity mechanisms beyond the standard Bardeen-Cooper-Schrieffer (BCS) model. On the other hand, the new superconductivity-based technologies emerge as the phenomenon is becoming more investigated and better understood. The coupling of THz frequency electromagnetic waves with superconducting matter and the emerging possibility of THz field generation, manipulation and detection via light-matter interactions in superconductors is the prime example . Superconductors present a wide playground for the future single-chip THz technology due to the rich electromagnetic response involving nonlinear processes. While the far-field THz nonlinearities in superconductors are being extensively studied for THz applications, the near-field nonlinear THz imaging would provide an insight to the superconducting excitations inaccessible in the linear regime  and with high spatiotemporal resolution. In fact, the THz-frequency electromagnetic radiation represents a peculiar energy scale of important condensed matter excitations - interaction mediators in correlated electron systems (e.g. phonons for Cooper pairs in BCS superconductors), making them an indispensable probe for other electron - electron coupling mechanisms in unconventional correlated systems. This project is aimed at (i) implementation of a nonlinear spatiotemporal near-field imaging technique, and its application to the investigation o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'INcreasing the InNOVation Management Capacity of SMEs in ISTanbul 2.0' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

INNOVIST 2.0 aims to provide Key Account Management (KAM) services to beneficiaries of Horizon 2020’s SME Instrument and providing services for “Enhancing Innovation Management Capacity” (EIMC) to SMEs in the Istanbul region. The main objective of the project is to contribute to enhancing the competitiveness, growth and profitability of SMEs in the region by assessing their innovation management capacities, performing gap analyses, and developing and prioritizing actions to resolve problems and further improve their innovation outcomes. The innovation management capacity and performance of a company will be assessed by using tools in compliance with the CEN/TS 16555-1 standard (such as IMP3rove or smE-MPOWER). A total of 115 SMEs will be provided this service, 105 of them targeted for EIMC services (7-10 days long), and 10 reserved for KAM services. The consortium will devote 1,8 FTE for these services for the 2017-2018 period.


**Keywords:** innovation management, innovation management capacity, assessment tool, SME Instrument, key account management, innovation strategy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MultiomIcs based Risk stratification of Atherosclerotic CardiovascuLar disEase' (MIRACLE), addressing dissemination and exploitation.

assistant: **Impact**

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality worldwide. Aside from asymptomatic manifestations, the first sign of clinically significant ASCVD is often a severe clinical event, such as stroke or myocardial infarction (MI). Thus, identifying individuals at high risk is crucial in preventing the fatal consequences of ASCVD. Current risk prediction models based on traditional risk factors, such as SCORE2, have limitations since they do not encompass all mechanisms and intermediary phenotypes leading to ASCVD. Particularly, current risk models fail to consider the disturbance of gene regulatory networks (GRNs) caused by genetic risk factors and diverse longitudinal exposures accumulating during a person's lifetime.Furthermore, the current models predict the combined risk of CAD, PAD and ischemic stroke despite mounting evidence of the heterogeneity of the underlying disease mechanisms. To capture the missing aspects of current ASCVD risk scores, MIRACLE project brings together unique data resources and expertise to provide novel multiomics based prediction models of ASCVD. We aim to (1) Integrate the globally largest CAD, PAD, and stroke GWAS information to identify genetic loci that differ between or are shared by these diseases and their subtypes, (2) Identify sex-specific subtypes of ASCVD patients using transcriptomic phenotyping of plaques and circulating biomarkers, (3) Generate functionally informed polygenic risk scores by combining experimental fine-mapping and gene prioritization approaches with integrative GRN and deep learning modelling. (4) Derive novel risk prediction models incorporating polygenic risk and circulating biomarkers. Providing a new gold standard for prediction models to accurately risk stratify stroke and MI r