RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Predicting the Properties of Carbonaceous Pitches via Molecular Modeling' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The dramatic escalation in energy prices over the past year has brought a new sense of urgency to the development of strong but lightweight advanced materials for increased fuel efficiency. With one-fifth the weight of steel and equal or superior properties, advanced carbon materials are clearly a key solution to today’s energy problems. Because of their exceptional stiffness and ultra-high thermal conductivity (4 times that of copper), the potential market and value to society of inexpensive, pitch-based carbon fiber with a good balance of properties is enormous. Unfortunately, the current processes for converting pitches into graphitic structures are much more of an art than a science, with the molecular composition of the starting pitches, a broad mol wt distribution (MWD) of polycyclic aromatic hydrocarbons (PAHs), being largely unknown. We propose a collaborative effort between Clemson University (USA) and NTUA (Greece), with experimental work at Clemson University providing critical input into the development at NTUA of experimentally validated atomistic and mesoscale models for carbonaceous, pitch-derived oligomers. The objectives for the proposed work at NTUA are as follows: 1. Use Clemson’s unique dense-gas extraction (DGE) technique to isolate oligomeric fractions (i.e., monomer through tetramer) of narrow and well-defined MWD from raw carbonaceous pitches. 2. With the experimentally obtained molecular structures and number distributions from Clemson as input, use molecular dynamics (MD) and replica exchange MD (REMD) to predict the experimentally measured phase densities, softening points, and heat capacities for each oligomeric fraction of pitch. 3. Use the above atomistic MD work to guide the development of mesoscale models for carbonaceous oligomers. 4. Us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantitative detection of bacterial endotoxin by novel nanotechnological approaches' in the context of a Horizon 2020 call.

assistant: **Objectives**

ENDONANO (Quantitative detection of bacterial endotoxin by novel nanotechnological approaches) addresses a key regulatory and safety issue, i.e., the unbiased quantitative detection of bacterial endotoxin in products for medical use and in drug development and toxicological studies. The currently adopted LAL assays are reliable only in limited conditions and prone to interference at several levels, and therefore cannot be applied to all products and substances. ENDONANO will exploit new concepts, based on the capacity of metal nanoparticles to adsorb endotoxin, and new detection methods, based on molecular beacons, for developing novel assays to quantitatively detect endotoxin in complex matrices and in a wide range of conditions. The scientific and technological goals of ENDONANO include: 1. Investigating the capacity of endotoxin to specifically inducing inflammatory reactions in human primary blood cells; 2. Developing new methods based on endotoxin capture by metal nanoparticles in complex matrices (biological fluids, emulsions, gels, etc.); 3. Designing and implementing signal generation and detection methods for the quantitative endotoxin measurement; 4. Planning assay prototypes to be developed and validated for commercial purposes. ENDONANO will train 4 PhD students in an overarching training programme that will include training-by-research, courses of technical, scientific, and transferrable skills, active participation to public scientific events, and intense intersectoral networking. The ENDONANO consortium encompasses three academic institutions with strong expertise in inflammation, advanced biosensing, and top expertise in nanotechnology and use of nanoparticles for modulating bacterial functions, two SMEs expert in development and commercialisation of dia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Magnetic Doping of 3D Dirac Semimetals' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A new field in condensed matter physics has emerged, dealing with new quantum states of matter originating from non-trivial topologies of the electronic band structure. Topological insulators were the first class of such materials. Dirac and Weyl semimetals are becoming the focus of the next major waive of research on topological matter. In these materials, the bulk valence band and conduction band touch at discrete points and disperse linearly (3D analogues of graphene). This project aims to answer a key fundamental question in this field: can time-reversal symmetry (TRS) breaking induce a Weyl state in a Dirac semimetal? The originality of our project resides on the idea of switching between Dirac and Weyl states using magnetism (TRS breaking), as the ON-OFF switch, instead of inferring the role of TRS by investigating Dirac and Weyl states in different compounds. We will synthesize epitaxial thin films of Cd3As2, the model 3D TDS, and induce a ferromagnetic state via magnetic doping. Subsequently we will perform a thorough investigation of the band structure (Dirac/Weyl cones, surface states and Fermi arcs), aiming to understand the coupling between magnetic and topological states, in particular, the switching between Dirac and Weyl states by breaking and restoring of TRS. In addition to its fundamental interest, this work has the potential to open a new research field dedicated to electrical switching between topological states, to be exploited in Dirac/Weyl-based electronic devices.


**Keywords:** Dirac, Weyl, topological, doping, ferromagnetism, band structure, ARPES, thin films, Cd3As2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Immunotherapeutic Vaccine for the treatment of Alzheimer’s disease'.

assistant: **Objectives**

The objective of this project is to develop a business plan for the continued clinical development and commercialisation of ALZ-101 – a novel therapeutic Alzheimer´s disease (AD) vaccine candidate designed to prevent neurodegeneration in the brain. AD is a therapeutic area in dire need of effective treatments. The disease, which primarily afflicts the elderly (65+), irreversbly destroys brain cells and affects the patient’s cognitive ability.  The exact mechanisms leading to AD are unknown. However, it has been found that the disease is linked to the aggregation and deposition of Aβ1-42 – one of the isoforms of fibrous Aβ peptide - into senile plaques in the brain.In recent years, significant efforts have been made to attempt targeting the clearance of Aβ1-42 through the administration of Aβ antigens (active immunotherapy) or anti-Aβ anti-bodies (passive immunotherapy). However, the development has been fraught with difficulties. Aβ1-42 oligomers are inherently unstable and heterogeneous. This precludes the development of efficient therapies.  Alzinova owns the AβCC peptide™ technology which allows for the development of a vaccine that specifically targets the endogenous substance that causes disease – a feat made possible by the unprecedented capability to stabilise the antigen.The product will be ready to enter the clinical trial in humans by the end of 2017. In the Phase 1 project, we will develop a business plan that will guide the future clinical studies and commercialisation (to be included in the Phase 2 project). The strategy is to take the product to the Phase I/IIa level and thereafter acquire strategic partner for continued clinical studies and market launch.Fighting AD is an EU-wide challenge as it affects 7.3 million people within the EU-27 countries. The e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'SUSTAINABLE AND EFFICIENT SOLUTIONS FOR SIMULTANEOUS AND CIRCULAR IRIDIUM AND MEMBRANE RECYCLING IN PROTON EXCHANGE MEMBRANE WATER ELECTROLYSERS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

IRION addresses the urgent need for sustainable solutions in the hydrogen economy by developing innovative recycling and manufacturing technologies for critical components of proton exchange membrane water electrolyzers (PEMWEs). The current reliance on scarce and expensive materials, such as iridium and fluorinated ionomers, poses significant economic, environmental, and geopolitical challenges for large-scale green hydrogen deployment. IRION tackles these issues by recovering these valuable materials from end-of-life catalyst coated membranes (CCMs), enabling their reintegration into new components and supporting the circularity of the PEMWE value chain. the project focuses on eco-friendly, low-impact recovery processes, including ionic liquids, DES, other green solvents and electrodeposition which offer high selectivity and efficiency while avoiding hazardous emissions associated with traditional methods like calcination. The recovered iridium and ionomers are purified and reused to manufacture new CCMs using advanced techniques such as inkjet printing and sputtering, ensuring optimal catalyst dispersion and membrane integration. IRION also includes the validation of recycled CCMs in real PEMWE systems, assessing their performance and durability compared to commercial materials. Comprehensive life cycle (LCA) and techno-economic (TEA) assessments will be performed to evaluate the environmental and economic viability of the proposed solutions. Moreover, the project will explore eco-design strategies for stack components, facilitating their future dismantling and recyclability. Ultimately, IRION supports Europe’s objectives under the Green Deal and Critical Raw Materials Act, reducing dependency on imports and minimizing environmental impacts through a circular and sca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Hyperpolarized Biosensors in Molecular Imaging'.

assistant: **Objectives**

Xenon biosensors have an outstanding potential to increase the significance of magnetic resonance imaging (MRI) in molecular imaging and to combine the advantages of MRI with the high sensitivity of hyperpolarized Xe-129 and the specificity of a functionalized contrast agent. Based on new detection schemes (Hyper-CEST method) in Xe MRI, this novel concept in molecular diagnostics will be made available for biomedical applications. The advancement focuses on high-sensitivity in vitro diagnostics for localization of tumour cells in cell cultures and first demonstrations on animal models based on a transferrin-functionalized biosensor. Such a sensor will enable detection of subcutaneous tumours at high sensitivity without any background signal. More detailed work on the different available Hyper-CEST contrast parameters focuses on an absolute quantification of new molecular markers that will improve non-invasive tumour diagnostics significantly. NMR detection of functionalized Xe biosensors have the potential to close the sensitivity gap between modalities of nuclear medicine like PET/SPECT and MRI without using ionizing radiation or making compromises in penetration depth like in optical methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards an emerging field of social neuroscience in human groups' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Group interaction is part of our evolutionary history and continues to be central to modern society. Whereas some groups function harmoniously and productively, others do not. Understanding group processes affecting these outcomes is vital because group discourse and actions affect individuals’ well-being and societal functioning. Examining the interactive biobehavioral processes that emerge between group members during shared tasks – the processes that influence actions, emotions, and cognitions - will enhance our understanding of group functioning and dynamics. Yet, a comprehensive understanding of the biobehavioral processes underlying successful group functioning remains elusive. To fill this gap, GROUPS focuses on the multimodal -- neural, physiological, and behavioral -- synchrony patterns emerging between group members. Interpersonal synchrony is a ubiquitous and spontaneous process; A key mechanism in social interactions that pulls us to clap in unison with the crowd or to join others in protesting for a just cause. Contextual factors and individual differences modulate multimodal synchrony by prompting us to connect with, or separate from, the group. Multimodal synchrony, in turn, enhances or reduces relational (cohesion, trust, rapport, identification) and goal-oriented (performance, efficacy, creativity) outcomes. The project’s objectives are to examine: 1) whether and how multimodal synchrony affects group outcomes on the individual-, dyadic-, and group- level; 2) how individuals’ traits (demographic, psychological, physiological) impact multimodal synchrony and its outcomes in groups; 3) how competitive versus cooperative interpersonal contexts impact multimodal synchrony and its effects on groups. Realizing these objectives will advance the science of huma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'BLUE OCEANS STRATEGY FOR VALUE CREATION'.

assistant: **Concept**

BEAGLE proposes an innovative methodology for value creation from the uptake of the research results applying the Blue Ocean strategy. It explores new market niches by fostering sustainable value chains in untapped markets, while promoting disruptive synergies and innovation. This will be achieved through constructing a BEAGLE network of 3 universities, 1 technology centre, 1 innovating communities’ manager and 4 industry clusters with a work plan which will be implemented by the active participation of 240 professionals from 7 European countries, both innovators (from industry) and researchers (academia and tech centre) through the application to an ad hoc open call. Multiple disciplines, sectors and geographic areas are called to connect and interact in this A-I BEAGLE community (mainly those of the participating entities). By the end of the project the goal is to unveil 20 new market niches, the Blue Oceans, and to co-create 20 innovation proposals with specific roadmaps.To facilitate the co-creation experiment 12 Mixed Teams will be set, expert researchers and TTOs officers form the academia and the technology centre will merge with the cluster managers and their representatives from the industry clusters. Those actors will lead, manage, and supervise the whole work plan starting by the recruitment of professionals from their own institutions (the mentioned open call), to actively join BEAGLE as participants of the proposed innovation funnel. Three phases are planned: I) discovering opportunities through co-creation activities (workshops, survey, interviews, video-factsheets, system innovation approaches); II) co-creating the innovation proposals; and III) consolidating 20 new innovative market niches to attract investment.A dedicated marketplace linked to the F6S p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Mechanical control of biological function'.

assistant: **Concept**

Mechanical forces transmitted through specific molecular bonds drive biological function, and their understanding and control hold an uncharted potential in oncology, regenerative medicine and biomaterial design. However, this potential has not been realised, because it requires developing and integrating disparate technologies to measure and manipulate mechanical and adhesive properties from the nanometre to the metre scale. We propose to address this challenge by building an interdisciplinary research community with the aim of understanding and controlling cellular mechanics from the molecular to the organism scale. At the nanometric molecular level, we will develop cellular microenvironments enabled by peptidomimetics of cell-cell and cell-matrix ligands, with defined mechanical and adhesive properties that we will dynamically control in time and space trough photo-activation. The properties under force of the molecular bonds involved will be characterized using single-molecule atomic force microscopy and magnetic tweezers. At the cell-to-organ scale, we will combine controlled microenvironments and interfering strategies with the development of techniques to measure and control mechanical forces and adhesion in cells and tissues, and to evaluate their biological response. At the organism scale, we will establish how cellular mechanics can be controlled, by targeting specific adhesive interactions, to impair or abrogate breast tumour progression in a mouse model. At all stages and scales of the project, we will integrate experimental data with multi-scale computational modelling to establish the rules driving biological response to mechanics and adhesion. With this approach, we aim to develop specific therapeutic approaches beyond the current paradigm in breast cance