RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Robustness in sparse random-like graphs' (RobSparseRand) under Horizon 2020.

assistant: **Objectives**

Sparse, highly connected, random-like graphs are currently a focal point in discrete mathematics, theoretical computer science and network science, motivated by the insight that  networks of this type are ubiquitous in computing, biology, economics, physics, social science, etc., and by the theoretical challenges of this setting. Random graph models used in statistical modelling of real-world networks include the Molloy-Reed model for scale-free graphs and the Watts-Strogatz model (designed to simultaneously exhibit the small-world phenomenon and formation of hubs, cited 43000 times). Barabási devotes a chapter of his classic network science book to robustness of random graphs, specifically addressing robustness against adversarial attack.                       Extremal combinatorics includes the fundamental study of sparse networks. Our line of enquiry  is  sparse Ramsey theory, concerning sparse graphs that are robust in a strong sense, with respect to adversarial edge-partitioning. This notion is also of interest in theoretical computer science. An archetypal robust graph in Ramsey theory is the  Erdős-Rényi random graph. Our project addresses some limitations of this paradigm.This projects aims to (1) solve important open problems in Ramsey theory, shedding light on a surprising synergy between structural and Ramsey-type properties of graphs, (2) open up new frontiers in sparse Ramsey theory by using a random Cayley graph (RCG) as a much-needed alternative sparse robust graphs to the Erdős-Rényi model, (3) advance the essential tools in random graph theory (sparse regularity framework, concentration bounds, embedding and colouring techniques) by taking them into an entirely new algebraic setting, (4)  illuminate potentially useful classes of expander graphs with bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multi-field and multi-scale Computational Approach to design and durability of PhotoVoltaic Modules' (CA2PVM).

assistant: **Innovation**

Photovoltaics (PV) based on Silicon (Si) semiconductors is one the most growing technology in the World for renewable, sustainable, non-polluting, widely available clean energy sources. Theoretical and applied research aims at increasing the conversion efficiency of PV modules and their lifetime. The Si crystalline microstructure has an important role on both issues. Grain boundaries introduce additional resistance and reduce the conversion efficiency. Moreover, they are prone to microcracking, thus influencing the lifetime. At present, the existing standard qualification tests are not sufficient to provide a quantitative definition of lifetime, since all the possible failure mechanisms are not accounted for. In this proposal, an innovative computational approach to design and durability assessment of PV modules is put forward. The aim is to complement real tests by virtual (numerical) simulations. To achieve a predictive stage, a challenging multi-field (multi-physics) computational approach is proposed, coupling the nonlinear elastic field, the thermal field and the electric field. To model real PV modules, an adaptive multi-scale and multi-field strategy will be proposed by introducing error indicators based on the gradients of the involved fields. This numerical approach will be applied to determine the upper bound to the probability of failure of the system. This statistical assessment will involve an optimization analysis that will be efficiently handled by a Mathematica-based hybrid symbolic-numerical framework. Standard and non-standard experimental testing on Si cells and PV modules will also be performed to complement and validate the numerical approach. The new methodology based on the challenging integration of advanced physical and mathematical modelling, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optimal sellection and reuse of construction debris' (1998-2002).

assistant: **Innovation**

The increase of the construction debris mainly due to renewal of the buildings and the associated dump solution begins to have a significant environment importance The main problem in the reuse of the construction debris is their variability which makes very difficult to define their characteristics and so to achieve uniformity of the recycled products. This project as the aim of defining strategies for optimal demolishing at the site, to develop techniques to separate the debris, to define the best characteristics of the crushed fragments, and the best proportions in the debris mix, and to define the type of construction elements that are more appropriate for each selection of debris. Prototypes of the systems to separate the debris will be implemented and some construction elements will be built and tested with optimal debris.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From pills to bio-electronics: a wearable neurostimulator for the personalised treatment of chronic pain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Chronic pain is one of the most underestimated healthcare problems in the world today, causing major consequences for the quality of life of the sufferer and a major burden on the healthcare system and society. One in five people in the general adult population – 150 million Europeans – have chronic pain, more than heart disease, cancer and diabetes  combined. With an aging population, the problem is likely to be felt even stronger in the years to come. Conventional treatment options offer only a partial response to the problem, with many people continuing to suffer with their severe chronic pain on a daily basis despite receiving several treatments. Consequently, there is a true and significant unmet need in optimal pain management. SzeleSTIM offers an innovative patient-centred, non-invasive pain management system based on electrical stimulation of the vagus nerve in the ear. Its unique biofeedback-controlled algorithm uses patient real-time physiological data for automatically adjusting the therapy. In this way, SzeleSTIM paves the way for truly individualized therapy, based on the patient’s individual condition and dynamic needs. In addition to pain management, other potential future applications of the AuriMod device include vascular diseases such as Peripheral Arterial Disease (PAD), but also migraine, or autoimmune diseases. The key objective of the project is to demonstrate the safety, efficacy and usability of AuriMod when applied to the auricle, confirming also the performance and usability of a therapy management system put in place, in order to eventually achieve CE marking and reimbursement in target countries.


**Keywords:** chronic pain, neurostimulation, vagus nerve, pain management, personalised therapy, treatment,  medical device, big data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Natural microbial interactions in winemaking-associated ecosystems as a tool to foster wine innovation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Eco2Wine project aims at providing a new generation of PhD graduated employees for the wine sector who will be able to manage winemaking-associated ecosystems, protect and control the biodiversity, and use this knowhow to reduce unsustainable interventions in natural environments while improving wine sustainability and “natural wine” production. Winemaking-associated ecosystems are complex environments in which more or less stable and evolutionary relevant interactions among species, and between each species and abiotic components, are established. In recent years the direct manipulation of these ecosystems has gained considerable interest in wine science because of the need of boosting sustainable, socially relevant and ecofriendly choices for the wine production while meeting the growing consumer demand for more diverse wine styles. To better map and exploit the natural biodiversity of winemaking-associated ecosystems, the understanding of the relevant microbiota, the various ecological interactions within those biota and of the molecular mechanisms involved in interactions is essential. Such studies will allow to describe how these ecosystems work and how their intelligent exploitation can benefit the wine world. The training program is divided in 4 areas of interest: wine ecology, wine innovation, wine business and wine science communication. The consortium includes 9 beneficiaries and 12 partner organizations that possess complementary competencies and are working with success in wine research. The level of quality of these institutions, the long-term collaborations established in the past joint European project, YeSVitE (GA612441), and the appropriate exchange scheme of training with private companies will sustain an efficient transfer of knowledge between PhD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'First of a kind bio n-butanol industrial facility' in the context of a Horizon Europe call.

assistant: **Objectives**

Catalyxx possesses an innovative, patented thermochemical catalytic biorefinery technology that transforms bioethanol into high-value bio-based chemicals such as bio n-butanol, bio n-hexanol, and bio n-octanol, offering sustainable alternatives to fossil-based feedstocks. With over a decade of technology development and 50,000 hours of testing leading to TRL7, Catalyxx has demonstrated success with its Demonstrator Plant operating for over 8,000 hours. The next milestone is the construction of the groundbreaking first-of-a-kind (""FOAK"") 15,000 tons per year plant. Positioned uniquely in the market with sustainable production methods, Catalyxx aims to cater to the rising demand for low-carbon chemicals, providing a cost-competitive and environmentally friendly alternative to traditional methods.Independent LCA analysis showcases our environmentally friendly approach with a carbon footprint of -1.0 kg CO2 eq/kg butanol compared to 2.5 kg CO2 eq/kg for oxo butanol. Our intermediate chemicals play a pivotal role in decarbonizing downstream value chains. Support from the EIC is essential to expedite technology scale-up, showcase performance at scale, attract further investment, and facilitate the transition towards sustainable petrochemistry.""


**Keywords:** bio n-butanol, Renewable chemistry, catalytic process, bioeconomy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adaptation Solutions for Regional Climate Resilience' to be submitted under Horizon Europe.

assistant: **Abstract**

The need: Despite their climate action, mission signatories still face major challenges in climate adaptation planning and implementation. Among specific needs to address the challenges and facilitate adaptation actions, the largest single need identified by 72% of the signatories was ‘knowledge’, replicated across most countries, geographical locations and types of regions.Strengths of the consortium: The REGILIENCE+ Consortium has demonstrated over the past 3 years its capacity to work together in providing coordination and support to climate adaptation Innovation Actions, as well as contributed significantly to the development of the Climate Adaptation Mission, the Mission Portal (e.g., inspiring and contributing to the tools database and the funding database). Expected outputs: Improved knowledge via 150 solutions in the form of case studies, adaptation options and tools included in online inventories (preferably Climate-ADAPT) and 70 multilingual communication products, services, and activities. Envisaged outcomes: Inclusion of inventory updates in mainstream climate adaptation knowledge platforms, and Use of communication products, services, and activities by MIP4Adapt, National organisations and initiatives (including National Adaptation Hubs), Regional and Local authorities, and other entities addressing climate adaptation. Established procedures for the inclusion of inventory updates are in place and used beyond the timeline of REGILIENCE+.Aimed impacts: Smarter, swifter and more systemic adaptation in European regions and local communities, due to improved access to and replication of available and actionable solutions.


**Keywords:** Inventory updates; Climate adaptation solutions; Climate adaptation knowledge platforms; Adaptation Mission
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Climate and environmental Monitoring with GPS Atmospheric Profiling.'.

assistant: **Concept**

Growing interest in the climate and the environment is resulting in a variety of activities to see in which way the global changes may be linked to anthropogenic affects, and how the changes may be monitored and controlled so as to develop the background for a healthier planet in the future. The advent of radio occultation techniques applied to signals from GPS satellites has proven to be a very promising approach for accurate measurements of temperature and humidity profiles up through the atmosphere. Feasibility of this technique has recently been demonstrated by the experimental GPS/MET project in the United States. Data from a single satellite borne GPS receiver will produce more than 500 temperature/humidity profiles per 24 hours world wide with a an accuracy of less than 1 degree K and with a vertical resolution of less than 1 km. The immediate impact of this will be significant improvements in modeling the upper troposphere and lower stratosphere. Further enhancements in climate modeling may be obtained by including measurements from ground based GPS receivers from which the Integrated Precipitable Water Vapour content (IPWV) may be estimated. In addition recent results indicate that significant improvements may be obtained in temperature profiles derived from combined AVHRR and TOVS measurements in the lower troposphere. Concomitant improvements in meteorological and climatological data will significantly advance the accuracy of environmental models for ambient air quality and locaVregional dispersion and transport models. Whereas the technology is being researched in Europe no system has so far been established operationally to bridge the gab to the end users of such data. Nor has a complete system concept been defined which can be used as a basis for an implem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rational design of enantioselective biotransformations in organic media, applied to lipases from rhizomucor miehei and candida antarctica' under Fourth Framework.

assistant: **Concept**

Superior enantioselectivity is an important driving force for the proliferation of enzymes in industrial biotransformations. However, on expanding the scope of enzymatic conversions to organic media substantial deviations from the intrinsic selectivity in aqueous solution have been observed. Ambiguous enantioselective behaviour of enzymes in organic solvents frustrates their use as customised catalysts in industrial processes. Since current attempts to establish (semi-) empirical correlations of enzyme enantioselectivity with bulk solvent properties turn out to be of limited value, fundamental studies are required. Main objective of this project is the understanding of medium effects on enzyme enantioselectivity. Our strategy involves the rigorous evaluation of mechanistic, kinetic, and thermodynamic contributions that may affect the enantioselective performance of lipases from Rhizomucor miehei and Candida antarctica in kinetic resolutions and asymmetrizations of chiral and prochiral alcohols and acids in organic media. R. miehei and C. antarctica lipases are versatile catalysts with great industrial potential. Extensive structural information is available for both enzymes. Judicious combination of dynamic and structural knowledge will provide a frame of reference against which molecular modelling techniques can be properly validated. By performing convergent mechanistic, thermodynamic and molecular modelling investigations on a limited set of targets, the participating groups expect to gain insight that will open novel perspectives for the rational design of medium-engineering tools applicable to a broad range of enzyme-catalysed kinetic resolutions of industrial interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An X-ray spectroscopy view on active sites: removing the obscuring silent majority' to be submitted under Seventh Framework.

assistant: **Abstract**

One of the holy grails in catalytic research is the determination of the structure of the active site. Information on the catalytically active site is notoriously difficult to obtain as it concerns a small minority of states in a sea of other silent states. This silent majority of states obscures the action that takes place on the active states. Because the core hole localizes the final state, X-ray absorption spectroscopy (XAS) is a powerful local probe of the electronic structure and XAS provides detailed information on catalysts under working conditions. A major limitation in the present experiments is the fact that the signal from the majority of non-active sites overwhelms the details from the active sites.In this proposal I will develop a new idea to solve this problem and allow x-ray spectroscopy  to unveil the nature of active sites. The idea is based on a detailed knowledge of the resonant x-ray emission (RXES) process that allows the detection of RXES spectra that are specific for the active state only. Model calculations predict an enhancement of the active sites over the silent sites of approximately a factor 50, allowing the clear detection of active sites above 1 %  presence.This method will be suitable to study active sites in heterogeneous catalysts based on transition metal ions. However, the approach is also suitable to study transition metal active sites in homogeneous catalysis and biocatalysis. In addition, the  proposed research will have an impact on first principles x-ray spectroscopy calculations in theoretical chemistry and theoretical physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing neural crest organoids with inducible neuroblastoma to model chemoresistance in MYCN amplification related high-risk cases' (NeuroblastORG).

assistant: **Innovation**

Neuroblastoma (NB) is the most common cancer in infants and the 3rd most common cancer in children. According to the WHO 90% of NBs occur in children younger than 5 years old and 15% of all pediatric cancer related death are due to NB. Approximately 20% of NB cases are characterized by the amplification of the MYCN gene, which is linked to more aggressive tumors and poor prognosis (high-risk NB). Despite recent treatment advances, relapsing high-risk NB often leads to death. Understanding mechanisms of therapy resistance can help to develop more effective treatment protocols.  However, investigation of acquired resistance upon chemotherapy is largely limited by the number of patients with high-risk NB and the availability of adequate model systems. Mice models of NB are often used, however species specific differences in sympathoblast development might result in misleading findings. Sympathoblast are the fetal counterparts of NB cancer cells and they are derived from the neural crest (NC).The overall aim of the NeuroblastORG project is to establish a human organoid model of the NC lineage, which can recapitulate human specific embryonic developmental stages, while also giving rise to sympathoblast-like NB cells, in addition to healthy sympathoadrenergic lineage derivatives (NB organoid). To reach this aim, human induced pluripotent stem cell lines will be genetically modified to overexpress the MYCN gene under the control of an NC-specific promoter, but only in a subset of NC cells within the organoids. Relevance of the established model will be validated by comparing gene expression signatures between NB organoids and human NB patient tumour samples.The NB organoid model system will provide a platform to simulate treatment of NB cells with NB-therapy relevant agents an