RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanotechnology: Training Of Experts in Safety' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Life Sciences and Nano Sciences interact today mainly in two areas: in the evaluation of accidental health and environmental effects derived from engineered nanomaterials, and in development and biological/clinical evaluation of nanoparticles with intended biological effects for application in medicine and biotechnology. It is essential for producers, distributors, consumers and regulators that the safety of products containing nanomaterials can be certified with reliable, validated assays. Research efforts are under way to establish suitable test methods and to understand mechanisms potentially leading to a detrimental impact of nanomaterials on human health and on the environment.  However, this important field still urgently lacks sufficient trained personnel. The ITN “Nanotechnology: Training Of Experts in Safety” (NanoTOES) will establish a network of research projects working towards the refinement and standardisation of existing methods, will develop novel assays, and will during this process provide interdisciplinary training to Early Stage Researchers (ESR) and Experienced Researchers (ER) working at the intersection of biosciences and nanosciences. A suite of methods developed and validated in the NanoTOES project shall have utility in characterising the biological effects of nanomaterials, including their impact on the environment, and will add significantly to our understanding of the biological actions of nanomaterials and their resultant effects on human health and the environment. Equally, the influence of biological entities (molecules, cells, tissues) on the properties of nanomaterials will be investigated. This aspect is crucial to understanding the properties of nanomaterials in organisms and in the environment, but nevertheless this issue has been so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Co-Benefits and Conflicts between CO2 sequestration and biodiversity conservation in European Forests' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Intact forests harbor large amounts of carbon and unique biodiversity, suggesting that protecting forests may benefit climate change mitigation and biodiversity conservation alike. Yet, forests also provide other essential services, from timber to energy to recreation. Balancing these multiple, sometimes conflicting objectives requires understanding trade-offs and synergies among them. A key question in this context is whether schemes to maintain or increase carbon stocks through forest management actually co-benefit biodiversity. Although frequently promoted, assumptions about such co-benefits have not been rigorously assessed. Forest and CO will test whether policies designed to protect either biodiversity or carbon in Europe’s temperate forests are synergistic or conflicting. Three work packages (WP) will focus on both unmanaged, old-growth forests, representing a baseline for key ecosystem functions, and managed forest, constituting the majority of Europe’s forests. WP1 will build a network of forest researchers to gather existing data on old-growth forests in Europe, and create the first map of their distribution. WP2 will use plot-level data to model the relationship between forest biodiversity and carbon storage, and assess whether this relationship differs between old-growth and managed forests. WP3 will test whether carbon/biodiversity co-benefits vary, when scaled up to broader extents, using satellite products and vegetation-plot databases. This action will provide new insight into the synergies and trade-offs between carbon and biodiversity in temperate forests and develop methods to map these trade-offs. Scientifically, this will contribute substantially to the fields of forest ecology, conservation science, and sustainability science. From a policy perspec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exploring the impact of Time-Restricted Eating and Exercise interventions on Gut microbiome of patients with hepatic steatosis and obesity – TREEGut' under Horizon Europe.

assistant: **Concept**

TREEGut investigates the role of the gut microbiome in reducing hepatic fat and improving cardiometabolic health through a novel intervention combining time-restricted eating (TRE) and exercise in individuals with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). Innovative and easy-to-implement interventions are necessary to alleviate the burden on healthcare systems and improve patient health affected by obesity-related diseases. The gut microbiome, implicated in disease pathogenesis, presents a promising therapeutic target. TRE, an intermittent fasting method that is effective and easy to implement, shows potential benefits that could be enhanced when combined with exercise. However, the extent of the microbiome's influence on these interventions remains unclear.TREEGut aims to elucidate how the benefits of TRE and exercise on hepatic fat and cardiometabolic health are mediated by changes in the gut microbiome, identifying specific microbial signatures and microorganisms that could inform personalized treatments. Under the supervision of Prof. Jonatan Ruiz at the University of Granada, TREEGut will integrate clinical assessments, gut microbiome analyses, and lifestyle interventions across human and mouse models, using advanced genomic technologies. A key phase of the project includes a secondment at Leiden University Medical Center (LUMC) supervised by Prof. Patrick Rensen, where specialised training on humanised mouse models for cardiometabolic diseases will explore the microbiome's causal role through human faecal transplantation in these models. This project will enhance the applicant's research capabilities and international network, fostering career development in metabolic disease and microbiome research. The findings from TREEGut wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photo-Engineered Helices in Chiral Liquid Crystals' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Supramolecular helices are a striking expression of chirality which is found at every level of biological materials, from plant cell walls to bones. Helical biomaterials formed out of equilibrium display multiple length scales, adaptation of structure to function and responsiveness to changing environments, a unique set of features that constitutes a fascinating source of inspiration for materials science. However, matching the complexity of these biological architectures by rational design of synthetic systems remains a major contemporary challenge. The aim of this project is to develop sophisticated helical materials with responsive architectures that are of interest in optical communication, energy management, photonic materials and mechanical actuation.The innovative and versatile approach proposed here consists in using light i) to engineer the period, handedness and orientation of the cholesteric helix, and ii) to stabilise the structures formed out of equilibrium by in-situ formation of polymer networks. Three tasks will run concurrently:Task 1: Stimuli-responsive infrared super-reflectorsTask 2: Dynamic templates for long range ordering of nano-objectsTask 3: Photomechanical actuation of helicoids and spiral ribbons“Phelix” will yield complex systems that reach beyond the state of the art in stimuli-responsive materials, push the frontiers of research on supramolecular helices and shed new light on transmission of chirality across length scales. Ultimately, the omnipresence of helical structures in nature means that biomedical applications could be envisioned also. The proposal builds on my recent investigations on light-responsive helices in cholesteric liquid crystals. I have demonstrated the expertise in liquid crystals, photochemistry and microscopy required
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Construction of a dense 3d probabilistic anatomical atlas for segmentation registration and labeling of multimodal images of the brain' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The need for medium or high-level 3D models for interpreting and comparing data from different medical imaging modalities, such as magnetic resonance (MR), computed tomography (CT) and positron/single photon emission computed-/tomography (PET, SPECT), has lead to the recent development of digital anatomical atlases. The goal of this project is to create a probabilistic anatomical atlas of the brain, coding information on anatomical structures and on biological variability of anatomy among a given population. 3D statistical deformable models will be considered to this end, for a dense 3D representation of the brain structures. As a first clinical application, the atlas will be used to the segmentation, registration, labeling and interpretation of epileptic areas in 3D multimodal image sequences of the brain. The clinical interest is to improve the analysis of epileptic seizures, providing a reliable pre-surgical diagnostic tool. The software for this approach will be implemented in C and it will be integrated within a multi-platform application for image processing (MEDIMAX), available for the scientific community.  Training content (objective, benefit and expected impact) This project will improve the candidate's knowledge in the discipline of medical image processing, in 3D multimodal image registration (MR/SPECT). It will compliment the candidate's experience, whose speciality is segmentation of CT images for RTP (Radiotherapy Treatment Planning). Her expertise will benefit to the project solving the segmentation problems related to the construction and matching of the atlas. Moreover, the applicant would like to see the techniques applied to MR/CT image registration at Walsgrave Hospital (Coventry), where the existing work on RTP has b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Missed Opportunities in Maternal and Infant Health: reducing maternal and newborn mortality and morbidity in the year after childbirth through combined facility- and community-based interventions' (MOMI) targeting Seventh Framework.

assistant: **Abstract**

Improving maternal and newborn health requires innovative approaches that maximise opportunities for impact throughout the continuum of care. In the past decade, maternal health services have largely focused on the management of intrapartum complications and on rationalising the package of antenatal services to include emergency obstetric care provided by skilled birth attendants. These interventions have sought to target what are widely considered to be the most common and immediate causes of maternal death.Yet this approach fails to address many underlying morbidities that are instrumental in generating high rates of maternal mortality, such as anaemia and inadequate birth spacing. Also missing is a direct focus on the substantial proportion of maternal deaths in the postpartum. Indeed, as a component of maternal health, postpartum care has been neglected, along with the field of newborn health in Africa. The essential package and optimum structure of postpartum services for women and newborns in Africa remains poorly defined, with missed opportunities for improved care.We thus propose developing a package of interventions targeting newborn health and women in the early postpartum period and throughout the first year after childbirth. This package will be delivered through a combined facility- and community-based approach designed to integrate services and strengthen health systems. It will be implemented in four African countries (Burkina Faso, Kenya, Malawi and Mozambique) by a consortium of five African and three European partners.Intervention design will be preceded and informed by a situational analysis of postpartum policies and practices in the four countries and a feasibility assessment. This will ensure that interventions are amenable to scaling up and approp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel Inorganic Nanostructured Materials and Devices with Enhanced Photoemission Activity and Thermal Stability' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of STABILIGHT is the design and demonstration of novel nano-photonic devices based on all inorganic nanostructured materials operating at low DC voltage with enhanced photoemission activity and thermal stability to be used both in passive and active (transistor) light emitting devices. Materials and technologies involved are addressed to large consumer-markets such as automotive, information displays and lighting. Specifically advanced mesoporous films and new photonic nanostructures will be demonstrated along with their application to automotive display and info panel devices.  The light emitting device developed in STABILIGHT will be characterized by an all inorganic active layer and electrodes on the same plane. The light is emitted on both sides. This device is designed to overcome the current limitations of OLED technology for automotive applications (low life-time at 80�C, very high investments, high cost because of the materials needed and relatively low yield because of the production complexity).  The active layer is characterized by a host conducting porous matrix with a network of well organized nanocavities in which are embedded luminescent semiconductor nanocrystals. The nanosized ordered cavities in the form of a mesoporous film will be grown on substrates which can be either thin glass or nanocomposite polymeric materials with tuned bulk and surface properties with the addition of inorganic fillers (e.g. layered silicates). The porosity of the film will be tuned so as to trade off high light efficiency against reduced complexity of the device.  The development of novel inorganic nanostructured materials having superior quality, reliability, sustainability and cost-effectiveness will allow an optimal incorporation into new nano-photonic devices. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of ShcC adaptor protein in neuronal survival and differentiation' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

I will test if ShcC-driven signalling events in postmitotic neurons are critical for neuronal viability and phenotypic stability.We will test this possibility by:1) producing mice and derive cells in which mature neurons are deleted of ShcC in a constitutive or inducible manner2) identifying promoter sequences and molicules important for ShcC expression in mature neurons3) identifying the downstream signalling events initiated by ShcC in CNS neurons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EUROPEAN LABCOURSE: ADVANCED METHODS FOR INDUSTRIAL PRODUCTION, PURIFICATION AND CHARACTERISATION OF GENE VECTORS' to be submitted under Sixth Framework.

assistant: **Abstract**

To allow gene & cell therapies to evolve more quickly into biomedical sciences, it is necessary to train the scientific community on: i the basic knowledge of the biology of vectors and stem cells, ii the expertise of their production, purification and characterisation, iii the assessment of their efficiency and bio-safety, iv the definition of regulations where they can be transformed into new medicines commercially exploitable. Their evolution is today still far from its objective, since the insufficient knowledge of their biology, a scarce co-ordination of research projects and the absence of integration of activities of the actors operating in different areas (research, industry, health products regulation and marketing). Therefore, the realisation of a multidisciplinary training programme, which integrates various scientific and technological approaches is necessary to address a real need of the community. This proposal concerns a theoretical and practical course, where 32 selected young researchers will be trained on the advanced processes of vector production, purification and quality control. The course is expected to gather young scientists from industrial and academic institutions, coming from several EU and candidate countries. It will present training and scientific innovations: for the first time the various aspects of the development of vector technology from the bench to the industrial level will be provided to the community. Theoretical modules will be open to large public including industries and regulatory agencies, and the status of the art will be presented and discussed. The course will a) allow young researchers from industries and academia to acquire hands on experience on vectors development and awareness of ethical, legal and socio-economical im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of vaccine candidates using reverse vaccinology' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Reverse vaccinology (RevVac) is an emerging field that uses bioinformatics to identify vaccine candidates directly from the genome sequence of pathogenic bacteria. The long-term goal of the proposed research is to identify new vaccine candidates that may be formulated into subunit vaccines that protect against bacterial pathogens. The objective of this particular application is to dramatically improve upon methods of RevVac developed in my laboratory. The central hypothesis is that my RevVac procedure will be enhanced by building larger training data sets, incorporating new protein annotation, assessing multiple machine learning methods, investigating additional validation techniques, and by facilitating open access to predicted vaccine candidates to the vaccine community through the Bacterial Protective Antigen Database (BPAD).Guided by published preliminary data in the journal Vaccine, my hypothesis will be tested by pursuing the following objectives: (1) To improve the prediction of vaccine candidates, (2) To understand what makes a bacterial protein a good vaccine candidate, and (3) To create a vaccine resource for bacteriologists. The rationale for the proposed research is that once there is high confidence in predicted vaccine candidates, then only a small number will need to be tested in animal models in order to identify those with protective effects that can be formulated into subunit vaccines.This proposal is responsive to the objectives of the work programme since it will establish my novel research talents and knowledge with respect to reverse vaccinology and gene expression biomarker analysis in the EU. In addition, I will bring a plethora of longstanding collaborations solidified while working in the USA. Finally, the University of Southampton is fully com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Global Seismic Tomography'.

assistant: **Objectives**

This proposal is meant to facilitate the transition of Prof. Auguste (Guust) Nolet from Princeton University back to Europe (Université de Nice/Sophia Antipolis). It addresses three aspects of his current research in global seismic tomography: 1. The merging of seismic data in different frequency ranges, including travel times and amplitudes of phases that do not satisfy the assumptions of geometrical optics ('finite-frequency tomography'), 2. Expanding the seismological data acquisition to the oceans by equiping underwater floats with hydrophones, 3. Incorporating wavelet expansions into the tomographic inversion. At a time that the first results from finite-frequency tomography are yielding very relevant results for an understanding of the Earth's chemical and thermal evolution, it is important that current research can be continued uninterrupted. The Marie Curie grant would enable active communication between researchers in the US and Europe with Nolet and his new students in France, and involve the oceanography group in Villefranche in the development of floats.