RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demonstration project : evaluation of the adjuvant activity of ifn-alpha in vaccination strategies against hbv' (1998-2002).

assistant: **Innovation**

Hepatitis B virus (HBV) is worldwide infection, which, even if mostly preventable by vaccination, still remains a public health threat. Critical issue of the actual vaccine prophiylaxis is the need to administer three or more closes of vaccine over several months for achieving immune protection in both healthy individuals and low-responder subjects. Due to the time-prolonged administration, a consistent portion of vaccinees (40-50%) fails to receive the third dose and the resultant reduced regimen induces insufficient response to provide seroprotection. Therefore, strategy to produce an earlier seroconversion/seroprotection rate to hepatitis B vaccine is highly desirable. Recent results strongly support a novel rationale for using IFN-alpha as vaccine adjuvant in humans. We intend to prove the efficicy of IFN-alpha as HBV vaccine adjuvant, in eliciting earlier and higher seroconversion rates, conferring seroprotection with a reduced number of doses in healthy unvaccinated individuals and circumventing the problem of unresponsiveness in individuals potentially low responder to the vaccine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Recombinant antibodies technology applied to methods for testing plant pathogens' to be submitted under Fifth Framework.

assistant: **Abstract**

The scope of the project is to produce a reagent for the detection of a plant pathogen by applying the recombinant antibodies (AB) technology. The regent will be embodied in an immunoassay to be used for the health control of agricultural productions. The test of improved performances is to supply the phytodiagnostic market The project intends to overcome the low efficiency of producing AB reagents of animal origin. A technological advance is achievable by introducing the technology of phage-display AB libraries into a whole in vitro process. The new production system will lead to a faster development of new tests for new targets as imposed by the high degree of plant pathogen diversity and therefore required by the market. The objective will be achieved by:1) engaging the RTD performers and SME partners;2) establishing the IPR consortium agreement;3) implementing the downstream in vitro process;4) implementing the SME exploitation plans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'European Training Network on  Grey-Box Models for Safe and Reliable Intelligent Mobility Systems'.

assistant: **Concept**

The GREYDIENT innovative training network aims at training a next generation of Early Stage Researchers (ESR) to fully sustain the ongoing transition of European personal mobility towards safe and reliable intelligent mobility systems via the recently introduced framework of grey-box modelling approaches. One of the main challenges that we currently face in this context is the integration of the data captured from the plenitude of sensors that are involved in a particular road-traffic scenario, ranging from monitoring car-component loading situations to power network-reliability estimations. The aim is to fully exploit the potential of merging these data with advanced computational models of components and systems that are widely available in industry in order to fully assess the momentarily safety. Grey box models are an answer to this pressing issue, as they are aimed at optimally integrating (black-box) data driven machine learning tools with (white-box) simulation models to greatly surpass the performance of either framework separately. However, the training of professional profiles in Europe who combine knowledge and experience in state-of-the-art data-driven black box and numerical white box approaches with expertise in methods for reliability and safety estimation is scarce. Therefore, GREYDIENT will train its ESR’s in a wide spectrum of fields, including the modelling, propagation and quantification of the relevant variabilities, the application of big data and machine learning methods, as well as the optimal combination of data-driven approaches with numerical models. All our ESR’s will obtain a PhD from an internationally respected University, build experience in communicating and disseminating their work, applying their research skills in a non-academic conte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring the tumor as a communicating organ' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The failure to bring about major advances in cancer care over the past decades points to the need for a revolution in our view of cancer as a disease caused by a lack of growth control in malignant cells. We propose that a tumor should be considered a communicating organ made of multiple cell types that collectively evolve into a clinically manifested and deadly disease. With this proposition follows that targeting of communication within tumors to attenuate the support from the stroma is the only viable strategy to achieve long term therapeutic benefit. Our research addresses the need to study the cellular context of cancer with a higher resolution. The general aim of the proposed work is to identify subsets of different cell types within the tumor stroma that hold utility as therapeutic targets and biomarkers. The work will be performed through a set of experiments bridging basic biology, pre-clinical studies and molecular oncology.The specific aims are:1)  Identification of cellular subsets of the tumor vasculature2)  Investigation of the therapeutic utility of cellular subsets of the tumor vasculature3)  Exploration of the potential of cellular subsets of the tumor vasculature as biomarkersThe aims of the study will be pursued through a series of methodological refinements. Firstly, identification of novel components of tumors will be achieved by the assembly of a mouse genetic tool box enabling isolation, lineage tracing and functional studies. Secondly, single cell transcriptome sequencing will be performed to identify cellular subsets using materials from both mouse and man. Thirdly, the utility as therapeutic targets of the new cellular subsets will be assessed using a live imaging approach. Fourthly, the clinical significance of the new cellular subsets will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reinventing Multiterminal Coding for Intelligent Machines' (IONIAN) targeting Horizon Europe.

assistant: **Abstract**

Advancements in sensors and deep learning have elevated the perception capacity of machines, bringing mid-level autonomy within reach. However, the abundance of high-dimensional data, including video and dynamic point cloud streams, strains current storage and communication technologies to their limits and curtails the ability of machines to collaboratively perceive the environment, a critical factor for achieving safety and the ambitious goal of high-level autonomy. State-of-the-art cooperative perception methods are based purely on a data-driven approach, requiring massive training data and computational resources, and lacking interpretability, explainability, and a solid theoretical foundation.This proposal puts forth a groundbreaking multiterminal coding paradigm for intelligent machines enabling data compression and communication systems that break the current limits of the predictive coding archetype. It builds a unique concept that unifies traditional distributed source coding and signal processing domain knowledge with modern deep learning. First, it leverages machine learning to solve long-standing problems in multiterminal coding theory and devise code constructions achieving the fundamental limits, thereby establishing a theoretical framework that defines the amount of information required to be sent per agent to solve the cooperative perception task. Second, it leverages domain knowledge to drive the design of interpretable and data- and parameter-efficient machine learning models for cooperative perception. Third, it reinforces this interplay by pioneering explanations that enforce and assess the interpretability of the designed models. IONIAN will have a profound impact on the way intelligent machines, including ground and aerial vehicles, and mobile robot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Innovative IST Platforms and Services to Support a Democratic Regional/Urban Planning Process'.

assistant: **Objectives**

The aim of the AGORA 2000 project is to develop innovative multimedia and integrated platforms and services designed to bridge the gap between citizens and regional/urban decision makers by creating an improved and easy-to-use on-line information access system, which will allow the participation to the regional/urban planning process. Indeed, democratic decision-making requires easy interaction between private citizens, elected representatives and those who are charged with advising, and implementing decisions. It is therefore vital that any planning process should leave space for discussion between the planners and both local authorities and the public. The project involves regional and urban decision makers from the following areas/ countries: Tuscany and Valle Maira (I), Aquitaine (F), Anatoli (EL), Valencia (E).OBJECTIVESThe AGORA 2000 project will define, specify and develop a networked, interactive and open AGORA Platform supporting regional/urban decision-makers in the territory planning process with monitored involvement of the citizens. The project is to provide a system which will (1) support the planning authorities by providing the means to present alternative solutions to a planning problem and quantitative parameters allowing for the comparison of them, and (2) support the public by providing a unified interface to all relevant planning information systems. Thus a planning decision will be explained and will invite comments from the public.DESCRIPTION OF WORKThe project will start identifying the user requirements for an improved and more democratic Regional/Urban Planning process, and subsequently it will undertake the definition of a global system architecture to support Planning actors and the debate with the public. Then, the specification and implemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Deconstructing Intestinal Immune Tolerance', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The intestinal tract is the main site of nutrient absorption and faces constant exposure to complex environmental stimuli. Intestinal barrier integrity and functionality are safeguarded by the intestinal immune system, which must balance its pro- and anti-inflammatory activities to provide protection from pathogenic microorganisms while preventing unwanted reactivity to self-antigens, commensal microbes, and dietary components. The intestinal immune environment can be viewed as a multicellular network in which the identity and function of individual cells is intrinsically programmed by transcription factors (TFs) that regulate their gene expression. These cells in turn can respond to signals in their environment and impact the behavior of their neighbors, which over time drives changes in tissue physiology. Conventional genetic knockout approaches offer insufficient temporal resolution to dissect these regulatory layers.In this proposal, we will employ chemical genetic protein degradation using the auxin-inducible degron 2 (AID2) system to deconstruct the intestinal immune regulatory network. These studies will focus on the role of Foxp3+ regulatory T (Treg) cells, whose continuous immunosuppressive activity is required to prevent the onset of intestinal inflammation. In Aim 1, we will use newly generated mouse models to probe the direct gene regulatory functions of key TFs that define intestinal Treg cell subsets. In Aim 2, we will fluorescently label intestinal Treg cells and rapidly degrade the TFs that confer their suppressive activity to study their functionality in situ. Finally, in Aim 3, we will use a reversible mosaic protein degradation strategy to study how the signals that precede and promote intestinal Treg cell differentiation shape the developing intestin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The development of equipment for the environmental control of dry rot' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Current methods for the eradication of dry rot (wood decay caused by the fungus Serpula lacrymans) in the built environment are not compatible with the needs of conservation as they require removal of original materials and the incorporation of modern replacements. New, more effective methodologies, such as 'environmental control', have not received wide acceptance as yet, due, in part, to the lack of essential supporting equipment. Using technologies currently used in other fields, e.g. medicine, coupled with novel visualisation strategies, we propose to develop equipment to assist in the use of the new environmental control methods. In addition, we will develop better monitoring systems, which will help to avoid the occurrence of dry rot in the first place. As dry rot is the major cause of timber failure in the built environment, these methods are entirely consistent with the need to conserve historic and architecturally important buildings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'THE ARCHAEOLOGY OF SOUND OF THE CULTIC THEATRE IN A GREEK CITY IN SICILY' (STESICHOROS) under Horizon 2020.

assistant: **Objectives**

Through this project I aim to assess and recover the lost intangible heritage of cultic theatre acoustics through the acoustic reconstruction of spaces of the past. The acoustics of linear and non-circular theatra in the Greek world have never before been analysed in terms of how and why these spaces were chosen for performance. The project will establish a new line of research at the crossroads of archaeomusicology, architecture, acoustics, and digital technologies to complete a study on these buildings, and will include a specific case study in Sicily. The acoustic reconstruction will also include audio material based on auralisations of ancient instruments. Through this project I will be able to expand my skills in the use of post-processing software and acoustic techniques based on computerised models. This application for the RI fellowship stresses my aspiration to develop new skills in digital heritage. The skills will be extremely useful for my return and reintegration into a longer-term research position in Italy, a nation that is well established in the fields of cultural and digital heritage studies. Securing the RI fellowship will be an important step in my career as an expert researcher with an original profile that blends archaeomusicology and digital heritage.I will be hosted at the Institute for Archaeological and Monumental Heritage of the National Research Council, a centre of excellence for the innovative development of relations between science and technology and different sectors of cultural heritage: the project will provide an opportunity for me to collaborate closely with experts in 3D reconstruction and modelling, augmented reality and applied acoustics. The host will benefit from the intensive collaborations I have built in the USA, and from my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scalable and efficient production of functionalized, high-performance solution-processable graphene-materials' (HIPER-G) targeting Horizon 2020.

assistant: **Abstract**

The worldwide increasing need for resources and energy as well as the foreseeable depletion of fossil fuels has led scientists into a race towards finding cleaner, more efficient and sustainable technologies. Graphene is believed to be able to play a crucial role in these developments due to its outstanding properties like excellent conductivity, mechanical strength, flexibility and chemical stability. A possible large-scale application is foreseen in polymer composites, where next to increased mechanical stability, graphene can introduce additional functionalities such as conductivity, antistatic properties or flame retardancy to specialty and commodity polymers. In addition, the potential to integrate cheap graphene-based, printed sensors, actuators, or networking capabilities into every-day products opens up completely new fields of application (e.g. the Internet of Things vision). Current industrial preparation techniques are available to provide graphene at large scale but the materials suffer from drawbacks in terms of processability, which is why despite the great potential, only a very limited number of graphene-enhanced products are available on the market. Recently, we were able to demonstrate a novel technology for the functionalization of graphene. With this approach, we are now focusing to produce functionalized graphene with tailorable properties and improved processability. This breakthrough will open up new possibilities and prospects for the application of graphene. To exploit the potential impact of this approach we are aiming to prove the usability of our functionalized graphene in different applications in cooperation with experienced partners from industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards a theory of mathematical signs based on the automatic treatment of mathematical corpora' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The SemioMaths project aims at proposing a formal model for the automatic analysis of mathematical corpora, based on semiological theories and on recent advances in formal and computational linguistics, in order to provide a broad and solid framework for the philosophy and the history of mathematics especially concerned with the study of mathematical practices. In order to achieve this objective, the action includes advanced training in the technical fields concerned by the project, the study of various existing mathematical corpora, the development of concrete implementations of linguistic computational models on mathematical corpora, and the elaboration of the corresponding results in the form of both scientific articles and a software package. Scientific training will be achieved by following suitable courses and exchanging with the research community of the host institution; the study of corpora will be done in close collaboration with the research team of the host chair; models will be implemented using the institution’s advanced computing infrastructure and IT support; finally, a teaching activity will help to systematize the conceptual grounds of the proposed approach. As a result of its inherent interdisciplinarity, other than in the specific fields of philosophy and history of mathematics, an impact is expected from the connections to be established with the other fields with which this project is concerned (computational linguistics, computer science, logic), and between the corresponding scientific communities. In this way, the SemioMaths project will improve our comprehension of the relations between mathematical knowledge and empirical textual practices. This shall result in a better understanding of the singularity of mathematics as a human practice and of