RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Shining a light on molecular mechanisms that potentiate phagocytosis of bacteria'.

assistant: **Innovation**

Antibiotics are among the greatest medical achievements of the 20th century and have significantly extended human lifespan. Nevertheless, bacterial infectious diseases continue to be a leading cause of death worldwide. Antibiotic treatment failures are common and typically linked to antimicrobial resistance (AMR), though resistance genes are not always present in such cases. Innate immune cells, particularly phagocytes serve as the first line of defence against infection, but they can paradoxically become reservoirs for certain pathogens. Within host cells, these bacteria are shielded from many antibiotic classes and may adopt persister phenotypes that confer tolerance, enabling them to survive phagocytosis and reinfect patients. My conviction is that tackling AMR and tolerance requires sophisticated approaches, where we need to find complementary pathways between immune response and antibiotic activity. Recent advances in super-resolution imaging will allow me to scrutinise molecular mechanisms in both host and pathogen that directly influence the outcome of phagocytosis. I propose to i), develop a super-resolution model of phagocytosis, using major AMR pathogen Staphylococcus aureus and host Drosophila melanogaster, to provide ground-breaking insights into the mechanisms of infection; ii), investigate how bacteria coordinate the cell cycle during infection, to identify vulnerabilities and test strategies to kill the internalised pathogens and iii), explore the roles of the host centrosome during phagocytosis, to determine how this organelle regulates the cytoskeleton and assess its potential as a target for immunomodulation. I will harness cutting-edge imaging technology to significantly advance the field of host-pathogen interactions. My main objective is to identify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Model driven Soil Probing, Site Assessment and Evaluation' (MODELPROBE) targeting Seventh Framework.

assistant: **Abstract**

Conventional techniques for site characterization are time consuming, cost intensive, and do not support decision making. Therefore, new techniques for step by step site characterization strategy with smart feed back loops are necessary. These will be able to support a future “soil framework directive”. Advanced geophysical site characterization techniques combined with new types of vegetation analysis will be developed. Based on these non-invasive surveys, the extension of sources, contamination levels (THP, BTEX, PAH, CHC, explosives, heavy metals and radio nuclides) and soil heterogeneities will be localized first. Hot spots will then be investigated by new direct push probing systems integrated with geophysical & hydrogeological methods and combined with chemical & isotopic contaminant analysis for source localization and identification (environmental forensics). The actually occurring bioprocesses, such as contaminant degradation or precipitation/mobilization processes, will be assessed using biosensors, in situ microcosms, and stable isotope and biomarker analysis. These new techniques and tools will be evaluated against best practice of conventional methods. Therefore, they will be applied at fully equipped and characterized European reference sites available in the project and will be provided to consultants and SME´s for application. Integrated statistical analysis and modelling at different stages of the step by step approach will result in an improved view of soil and subsurface contamination and will provide a sound basis for risk assessment and decision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'European Researchers' Night 2020 in Malopolska (Malopolska Researchers' Night 2020)'.

assistant: **Concept**

European Researchers’ Night (ERN) in Malopolska will be organised for the 14th time in our region. The event will be held in 8 cities of the Malopolska Region (Kraków, Tarnów, Nowy Sącz, Niepołomice, Oświęcim, Skawina, Chrzanów and Limanowa) to show the wide scientific heritage, with access not being a barrier to the participation of the residents of various parts of the region as well as the whole country. Events will be organized in approx. 50 locations in ca. 30 partner institutions (both those included in the project consortium and other partners involved in the organization of the ERN program in all cities). Researchers from participating institutions prepared approx. 1,500 different activities, including e.g. interactive workshops, demos and experiments, meetings with researchers etc. The preparation of such a diverse programme will involve approx. 1,500 people every year: scientists, R&D employees from companies and students, as well as 60 science clubs. ERN 2020 will be organized under the slogan ""How do researchers change our world?"" Particular emphasis will be placed on the role of scientists in the fight against various environmental threats, as well as against air pollution (including smog and climate changes) - they will share their discoveries with the ERN participants that aim to save our planet. An important distinction of the ERN among other events is that we focus on interactivity. During the RN, the researchers present their work combining learning with entertainment (edutainment), to make children and young people as passionate about science as possible. But the participants themselves will feel like real researchers performing unusual experiments under the watchful eye of their mentors. The project has European dimension – due to its broad and div
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Role of the Grhl1 gene in skin cancer'.

assistant: **Innovation**

Many functions of the Grainyhead-like (Grhl) transcription factors have already been studied in various animal models. So far these studies have been primarily concerned with the roles of such factors in development and wound healing. Now we have new preliminary data indicating that the Grhl factors are potential novel tumor suppressors. We have already established that the Grhl1-deficient mice have increased susceptibility to chemically induced cutaneous tumor development. We have also generated a list of putative targets of GRHL1 regulation, which are known to be involved in cancer. The proposal outlined here aims to further investigate the role of the Grhl1 gene in skin cancer. We plan to characterize the process of tumorigenesis in the Grhl1-null mice in response to chemical carcinogens and UV radiation. We will analyze the proliferation, differentiation and apoptosis in the induced skin of Grhl1-deficient mice and in the Grhl1-null keratinocytes. We will examine the expression of candidate GRHL1 target genes in these contexts and the binding of GRHL1 to its putative target sites. We will profile changes in gene expression during chemically- and UV-induced tumorigenesis in the Grhl1-deficient mice using microarray technology. Our ultimate aim is to unravel the molecular mechanisms underlying the Grhl1 function in skin cancer. The results of this work may thus have medical significance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Forest management by small farmers in the Amazon - an opportunity to enhance forest ecosystem stability and rural livelihood'.

assistant: **Concept**

Although significant progress has been made in the attempt to adapt the concept of sustainable forest management (SFM) to the situation of small farmers in the Amazon, there are still many obstacles that need to be overcome before it can be successfully i mplemented. In many situations SFM concepts for small farmers have been externally defined and do not correspond adequately to their livelihood systems and competences. This proposal aims to incorporate the needs, views and capacities of small farmers in the development of forest management strategies. For this purpose the project will identify and analyse existing local forest management initiatives in the Bolivian, Brazilian, Ecuadorian and Peruvian Amazon, where farmers have decided to manage and no t clear forests for other land-use purposes. Following the approach of Integrated Natural Resource Management", the project will analyse institutional, environmental and technical aspects within the livelihoods of small farmers, to assess and value the local viability and possible contribution of different forest management strategies to the ecological stability of the different Amazon regions. Through the application of both Participatory Action Research and traditional research approaches, the proje ct will ensure local relevance and constructive learning processes, as a basis for the development of key indicators for SFM by small farmers in the Amazon. The collaborative research between European and South American partners in equitable partnerships as well as the involvement of an international research center will increase Europe's participation in international research initiatives. The project will directly contribute to one of the priority problems of the partner countries, which is how to com bine forest conserva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Engineering Swarm Intelligence Systems' (E-SWARM).

assistant: **Innovation**

Swarm intelligence is the discipline that deals with natural and artificial systems composed of many individuals that coordinate using decentralized control and self-organization. In this project, we focus on the design and implementation of artificial swarm intelligence systems for the solution of complex problems. Our current understanding of how to use swarms of artificial agents largely relies on rules of thumb and intuition based on the experience of individual researchers. This is not sufficient for us to design swarm intelligence systems at the level of complexity required by many real-world applications, or to accurately predict the behavior of the systems we design. The goal of the E-SWARM is to develop a rigorous engineering methodology for the design and implementation of artificial swarm intelligence systems. We believe that in the future, swarm intelligence will be an important tool for researchers and engineers interested in solving certain classes of complex problems. To build the foundations of this discipline and to develop an appropriate methodology, we will proceed in parallel both at an abstract level and by tackling a number of challenging problems in selected research domains. The research domains we have chosen are optimization, robotics, networks, and data mining.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Coordinating National Research Programmes and Policies on Security at Major Events in Europe'.

assistant: **Objectives**

The proposal “Coordinating National Research Programmes and Policies on Security at Major Events in Europe” (EU-SEC II) builds upon the EU-SEC project. Making full use of the capabilities and experience of its Consortium Partners - governmental authorities from EU MS - and avoiding overlapping with ongoing activities, EU-SEC II aims to respond to the dispersion of efforts and lack of coherence that hinder firstly the interaction between European technology research stakeholders and secondly the coordination between national and European efforts to achieve cost effective security solutions. The main goal is to contribute to the harmonization of national research policies and to the common understanding and identification of needs and priorities among its partners, which constitute the demand side of the EU technology market. EU-SEC II will carry out networking activity and set up and implement joint activities to identify common research policies in the field of security at Major Events, by addressing how end-users and suppliers could more effectively cooperate, how to encourage and direct security innovation and how to define new security standards. A further objective is to elaborate a strategic security research roadmap to guide and orientate European and national research programmes and the consequent allocation of funds. The main result of EU-SEC II will be the synchronization of end-users into a coordinated platform of EU MS to affect the other stakeholders involved in the provision of security at Major Events and to drive the European market to be more ‘requirement pulled’ than ‘technology pushed’. Moreover, the Consortium of EU-SEC II will be in the position to elaborate common security research policies and to commit its partners in future activities and calls l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MagMech: Precision magnetic tweezers for the mechanobiology of cells and tissues.' (MagMech) targeting Horizon Europe.

assistant: **Abstract**

The mechanobiology of cells and tissues plays an essential role in physiology and diseases. This emerging field at the frontier between physics, engineering and biology, heavily relies on precise and  versatile devices to apply and measure mechanical forces within and around cells and tissues. However the current commercial landscape is restricted to few systems that are limited to a small range of forces and poorly compatible with large tissues and embryos. In the FORCASTER ERC Consolidator project, our team invented a magnetic tweezer system which allows to apply large calibrated forces on magnetic particles embedded within cells and tissues, or at their surface, which largely overcome the limits of the current commercially available devices. In the MagMech PoC we will: (i) perform key technological updates to improve the versatility, stability and precision of the device; (ii) Gather proof of concept data in multiple relevant tissues, organs and embryos to support its broad potential for studying the mechanobiology of cells and tissues in a variety of physiological and disease contexts and; (iii) Starting from the recent filling of a patent, perform market evaluations, including KOLs and end-users interviews, establish partnerships with different industrial sectors, as well as consider the creation of a start-up to support the commercialization of this technology in the near future. With this PoC project, we will thus assess the value proposition that the magnetic tweezer system developed in FORCASTER ERC project can be brought to the market, serving as a key alternative to the existing commercial systems, for applying and measuring forces within and around cells and tissues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification and substitution of mutagenic dyes in textile finishing' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Numerous reports regarding mutagenic and carcinogenic substances in textiles in recent years have made consumers become unsure. The majority of textile processing chemicals are existing substances (Altstoffe") and are therefore often insufficiently researched and tested. Although test methods for mutagenicity are available, this problem has not yet been targeted. Therefore, this proposal is going to identify mutagenic textile dyes with the aim to eliminate them from textile dyeing processes. This work shall be done in close cooperation with the involved industry. The waste water streams of the finishing textile process, dyes, and textiles will be examined for mutagenicity and the sources for these mutagenic effects will be identified. The elimination of these hazardous substances shall lead to considerable improvements in industrial health and safety standards during the dyeing process, improvement in the waste water quality and especially to better consumer protection. SMEs in the area of textile refining from various EU countries will take part in this project. This will guarantee that the different types of textile dyes and the legal backgrounds from the various EU countries will be taken into account. The project will result in an increased confidence in the ecological quality of European textile products, which will lead to a competitive advantage in the world wide textile market."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Marine annelids as a model for disentangling the molecular basis underlying the evolution of reproductive strategies and reproductive timing'.

assistant: **Innovation**

Alternative developmental and reproductive programs provide powerful sources of adaptive variation, which greatly enhances survival in changing environments. Yet, how divergent reproductive strategies and traits evolve remains poorly investigated particularly in the ocean, where the dramatic effects of climate change and anthropogenic impact on reproductive dynamics threaten entire animal communities. For this, I plan to close this knowledge gap by investigating the molecular and genomic basis underlying the divergent reproductive strategies and reproductive timing in Platynereis marine bristleworms. These animals are easy to breed in laboratory conditions, are genetically-accessible, and display a kaleidoscopic diversity of reproductive traits in closely-related species. Specifically, I plan to: 1) dissect the molecular mechanisms of the drastically divergent reproductive strategies of the sister species P. dumerilii and P. massiliensis, and 2) decode the genomic basis of alternative lunar reproductive periodicity in Platynereis species. Thus, I will combine my experience in working on the reproduction and chronobiology of these models with evolutionary genetics, population and comparative genomics, functional genomics and transcriptomics strategies mastered in the host lab. On one hand, I will provide ground-breaking insights on how molecular machinery can be drastically rewired generating novel and adaptive combinations of reproductive traits. On the other, I will shed light on the elusive molecular nature of lunar reproductive periodicity, a widespread phenomenon particularly in the marine environment, and its evolution. Currently, endocrine disruption and light pollution are severely affecting animal sexual development and reproductive timing, respectively, challen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intersex- New Interdisciplinary Approaches' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Intersex people are a highly marginalised population whose specific healthcare, social and human rights issues are often overlooked. The United Nations estimates that between 0.05% and 1.7% of infants are born with intersex traits, but intersex is largely invisible at legal and cultural levels. Intersex infants and children are often subjected to medically unnecessary genital surgeries in order to make them conform to physical norms. The dearth of policy frameworks and mechanisms to support intersex people’s social acceptance and inclusion is one reason for this. Non-essential intersex medical treatments are increasingly addressed as damaging to intersex people’s wellbeing, and as breaches of their human rights. Intersex people are diverse and continue to face exposure to multiple forms of discrimination, requiring cross-sectoral policy responses in fields including healthcare, education, and the law. Accordingly, the INIA ETN proposes to train a cohort of 10 early stage researchers working collaboratively to develop knowledge that will inform policy making and practice across a range of key sectors. The training addresses central issues for intersex wellbeing and rights, drawing on intellectual resources provided by legal studies, gender studies, medicine and healthcare, sociology, social work, political science, social policy, cultural studies, and psychology. The practical focus of the programme will be on developing topical and original applied outputs of relevance to stakeholders concerned to support the wellbeing and rights of intersex people. The project will, thanks to the unique competencies of the consortium partners, train a cohort of highly skilled researchers who will enable fast-track developments of intersex studies, policies and practices, working in a m