RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Crosswind-Reduced Separations for Departure Operations'.

assistant: **Innovation**

Increases in air traffic over recent years have resulted in congestion at many airports. The need to increase airport capacity is one of the major challenges facing ATM research today. Such an increase could be achieved by reducing the current separation minima while maintaining levels of safety. ICAO separation standards for landing and take-off were implemented in the 1970?s to protect an aircraft from the wake turbulence of a preceding aircraft. However research has shown that the transport and persistence of wake vortices are highly dependent on meteorological conditions, so that in many cases the ICAO standards are over-conservative. By developing a full understanding of wake vortex behaviour in all weather categories separations could be reduced under certain suitable conditions. The CREDOS project will study the operational feasibility of this approach by focussing on the situation for take-off under crosswind conditions. Although this represents only part of the scope of application, the methods and tools developed by this project can be later used to cover arrivals and other meteorological conditions. The aim of CREDOS is to prove that this approach to reducing separations is valid and feasible. The project will use recordings of wake vortices taken at St Louis and Frankfurt airports to develop models of wake vortex behaviour. Using Monte Carlo simulation techniques these models will be used to establish safe separations under various crosswind conditions. Building on work already completed, an operational concept for crosswind departures will be developed and validated in accordance with the Operational Concept Validation Methodology. The project will also produce an algorithm for detecting wake vortex encounters from flight recordings and this will be used as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Digital Twinning for Personalized Atrial Fibrillation Care' (TwinCare-AF).

assistant: **Concept**

The goal of the TwinCare-AF project is to develop innovative core methodologies for accurate and real-time calibration of cardiovascular electrophysiological models and to support medical decisions in the context of atrial fibrillation and catheter ablation therapy planning. The proposed approach will focus on the generation of digital twins of patient hearts, calibrated through robust and efficient machine learning techniques, and able to replicate measured clinical data, such as electrocardiogram and electrogram recordings.  Specifically, physics-informed and/or deep-learning techniques will be extended and implemented within the context of anatomically-accurate  and biophysically-detailed cardiac electrophysiology, to accelerate the solution of classical forward electrophysiological model, and to solve inverse problems for identifying patient-specific physical and tissue properties of the heart. Additionally, a robust methodology for verification, validation, and uncertainty quantification will be adopted to showcase the agreement between model predictions and empirical observations, and to provide reliable estimates of confidence in the model predictions. The developed approach will be used to predict atrial fibrillation progression and determine potential ablation sets for individual patients. The predictions of the developed model will undergo testing through in vivo intraoperative clinical measurements. To enhance easy flow, robust analysis, and interpretation of patient-specific data, the novel real-time mathematical workflow for atrial fibrillation simulations will be integrated into a clinically viable platform. These tasks will leverage leading-edge mathematical methodologies, improve the observation-to-diagnosis clinical process by efficiently handling patie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Self-propelled tyre scrap processing triturator' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to overcome demanding problems of the tyre scrap (in addition to other solid and inorganic wastes) in Rubbish damps, mainly: 1. The space problem and the using of wastes as energy sources or recycled raw materials. 2. The investment needed in a recycling plant in relation with the production-rate obtained, if Rubbish damp wants to use wastes as a value good. The technical objective is to develop a self-propelled machine that allows reducing and separating (for recycling or re-using) tyres and various kind of wastes, moving around different Rubbish damps disseminated in a local area. This self-propelled machine avoids great disbursements in permanent machinery, as just one machine is able to work where it is required with ajob-shop" production method. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eco conversion of lower grade PET and mixed recalcitrant PET plastic waste into high performing biopolymers' under Horizon Europe.

assistant: **Concept**

ECOPLASTIC is designed to provide a seamless route to resolving pervasive PET plastic pollution, converting it to Eco-plastic prototypes. Conversion of unrecyclable post use PET into new, high performance bioplastics embodies the regenerative zero waste approaches found in nature, where post use materials become the ingredients for new products and with unlimited cyclical use of materials. It proposes a technological paradigm shift in recycling from the current zero to single digit circuits of recycling loops to a regeneration process providing a significant scientific step forward towards true circularity. ECOPLASTIC converts lower grade PET and mixed recalcitrant PET plastic waste into high performing biopolymers, through the development of a suite of breakthrough modular and technologies adaptable to the waste input,  to funnel waste PET plastics into Eco-products that enter a perpetually bio-cyclable loop. The new Eco-plastics and products will provide drop in alternatives for seamless adoption within industry and by consumers. We will demonstrate that the resulting processes are economically & environmentally sustainable for valorizing currently non-recyclable materials such as multilayer packages and flexible films. The project will combine several approaches to optimise the material circularity:I.Depolymerization process: Series of mechano-green, chemical and biocatalytic technologies to depolymerize them into their constituent monomers, using novel biological filtration for the preparation of highly fermentable monomer and oligomer feedstock streamsII.Biopolymer production using microbiome processing to produce new biopolymers from monomer feedstocks which are then processed into bioproduct prototypes that are not harharmful to the environmentIII.Advanced proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent Use of Buildings' Energy Information' under Seventh Framework.

assistant: **Concept**

The energy consumption in the operational phase of buildings is one of the major contributions to energy use in Europe. The improvement of energy efficiency only in the renewed stock (new and renovated buildings) is too slow considering the ambitious goal to improve the energy efficiency by 20 % before 2020.IntUBE will lead to increased life-cycle energy efficiency of the buildings without compromising the comfort or performance of the buildings by integrating the latest developments in ICT-field into Intelligent Building and Neighbourhood Management Systems (IBMS and NMS) and by presenting new ICT-enabled business models for energy-information related service provision.By using the existing building stock more efficiently with the help of the new tools and business models developed in IntUBE, the potential to reach the goal is considerably increased. The solutions will also be applicable to new buildings.The results of IntUBE will benefit many actors in the building sector like the owners, the users, the energy service providers, maintenance service providers, etc in form of well-performing buildings that use the natural resources (especially energy) optimally, resulting in less environmental effects and reduced life-cycle costs of energy.The IntUBE consortium consists of universities, research centres and companies from Southern to Northern Europe. They all have established dissemination channels, and the SMEs of the consortium will be able to extensively exploit the results in their business.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stochastic Modeling of Spatially Extended Ecosystems and Ecological and Climate Data Analysis' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The coupling between ecosystems and the climate implies that quantifying their dynamics is crucial for our attempts to prevent undesired changes in our environment. The main goal of this project is to use non-linear, stochastic modeling in the context of climate and ecosystems dynamics. This proposal combines methods from statistical physics, non-linear dynamics, game theory and random dynamical systems to study the various effects of noise on climate and ecosystems dynamics. The specific goals of this project are:(i) Using the record of past climate observations to build dynamically-weighted forecasting ensembles adjusted to specific climate variables. These ensembles will enable inter-comparison of the models. Using the sequential compound decision method will reduce the uncertainties of climate predictions. (ii) Investigating the dynamics of non-linear vegetation models, in the homoclinic snaking regime, in the presence of global and local noise. Early-warning signals and the possibility of desertification not through critical transition but through a series of transitions between localized states will be studied. (iii) Analyzing data describing the process of vegetation mortality under controlled and natural drought conditions. Spatial and temporal patterns in the mortality process will be studied and related to quantitative models. Theoretical models will be developed and tested against the data. The expected results of this research will not only improve our understanding of climate and ecosystems dynamics but will also advance fundamental physics research such as the interplay between complex non-linear dynamics and stochastic effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting Microglia vulnerability to STress response  in Multiple Sclerosis through human iPSC modelling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Shifting from the traditional focus on central nervous system-targeting lymphocytes, MiST-MS posits that glial responses, particularly cellular senescence, are required to compartmentalized self-sustaining chronic inflammation in multiple sclerosis (MS) and related long-term clinical outcomes, including disability. MiST-MS is specifically designed to address the urgent need to identify new therapeutic targets to halt MS clinical progression through two interconnected research lines.The project will first identify cell-specific perturbations and molecular pathways associated with inflammation-driven early brain aging using MS human iPSC-derived microglia and genome-wide CRISPR-Cas9 screenings. By employing cutting-edge computational methodologies (single-cell CRISPR-seq, multi-omics integration, composite assessment, and cellular networking/signaling), MiST-MS offers a unique opportunity to identify and dissect mechanisms underlying microglia resilience versus vulnerability and their impact on stress responses, both independently and within the context of hiPSC-derived inflamed glia-enriched brain organoids. MiST-MS represents a ground-breaking modeling pipeline to study inflammation-driven early brain aging in MS. At the patient-level, since MS patients with evidence of smoldering inflammation (marked by the presence of chronic active lesions by in vivo MRI) exhibit poor tissue repair capacity and worse clinical outcomes, the project will also aim to identify common and divergent glial and neuronal responses between MS patients with and without chronic active lesions generating human iPSC lines for personalized medicine applications. In summary, MiST-MS is a highly innovative interdisciplinary project that provides an unprecedented understanding of microglia states in r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Study of the 'cross-talk' between two cytokine receptors - ifn - a and il-12 receptors - sharing the protein tyrosine kinase tyk2'.

assistant: **Innovation**

Research objectives and content Tyk2 belongs to the JAK family of intracellular tyrosine kinase implicated in signaling through cytokine receptors. Tyk2 is activated by IFN-alpha and IL-12 binding to their respective receptors. Tyk2 contributes to IE7N-alpha signaling not only as an active tyrosine kinase, but also by sustaining the steady-state of IFNAR1, one of the two IFN-alpha/beta receptor components. The major goal of my research proposal is to compare the role(s) of Tyk2 in the two receptor complexes and test a model of cross-talk between them. My work will be organized as such: 1. investigate in more depth the observed << dependence >> of IFNAR1 from Tyk2 2. verify if the level of Tyk2 has a comparable role in sustaining the level of the beta1 component of the IL-12 receptor 3. test if the level of IFNAR1 and the cellular response to IFN-alpha can be modified by co-expression within the same cell of another Tyk2-interacting receptor. Training content (objective, benefit and expected impact) The investigation of molecular mechanisms of the regulation of the response to two major cytokines involved in natural and acquired immunity may provide with a paradigm for other cytokine signaling pathways and may help towards understanding the mechanisms of abnormal regulation occurring in cancer and autoimmune diseases. Joining the group of DR.S.Pellegrini will give me the possibility to acquire a stronger theoretical and technical expertise in the field of signaling, in biochemistry and immunology, considering the facilities available in her laboratory and in the Institut Pasteur. Therefore I will be able to apply this knowledge once back to my country of origin, Italy. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ADDITIONAL LOSSES IN ELECTRICAL MACHINES' (ALEM) targeting Seventh Framework.

assistant: **Abstract**

Electrical motors consume about 40 % of the electrical energy produced in the European Union. About 90 % of this energy is converted to mechanical work. However, 0.5-2.5 % of it goes to so called additional load losses whose exact origins are unknown. Our ambitious aim is to reveal the origins of these losses, build up numerical tools for modeling them and optimize electrical motors to minimize the losses.As the hypothesis of the research, we assume that the additional losses mainly result from the deterioration of the core materials during the manufacturing process of the machine. By calorimetric measurements, we have found that the core losses of electrical machines may be twice as large as comprehensive loss models predict. The electrical steel sheets are punched, welded together and shrink fit to the frame. This causes residual strains in the core sheets deteriorating their magnetic characteristics. The cutting burrs make galvanic contacts between the sheets and form paths for inter-lamination currents. Another potential source of additional losses are the circulating currents between the parallel strands of random-wound armature windings. The stochastic nature of these potential sources of additional losses puts more challenge on the research.We shall develop a physical loss model that couples the mechanical strains and electromagnetic losses in electrical steel sheets and apply the new model for comprehensive loss analysis of electrical machines. The stochastic variables related to the core losses and circulating-current losses will be discretized together with the temporal and spatial discretization of the electromechanical field variables. The numerical stochastic loss model will be used to search for such machine constructions that are insensitive to the manufa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hardmetal Measurement Method Evaluation and Research' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This European collaboration will help maintaill and improve the competitiveness of the European hardmetal industry with respect to imports from USA and Japan, and also China in the future, through the development of products with better reliability and higher quality. The participation of Ieading industry supplies, producers and users in the network will provide an excellent dissemination route for the network output and will support the development of a common language between these different groups. Industry members have expressed an initial desire for new methods for measuring the grain size and distribution of hardmetals. rt is proposed to set up a thematic network will have as its first objective the exploitation of current best practice and the identification of new research requirements on this subject. The core organisations initiating the activity comprise: Sandvik (Sweden) - Producer, User, Industry NPL (UK) - Research H C Starck (Germany) - Precursors, Intermediates, Industry TU Vienna (Austria) - Research Swedish Institute for Metals Research (Sweden) An additional company, French is being approached as a likely source of image analysis expertise. Hardmetals are composite materials which are compacted under high pressure and sintered at high temperature. They are hard, strong and tough. They are used for metalcutting, rock-drilling and wear parts in the mechanical engilleering, machine tools, automotive and aerospace industries. Hardmetals are dominant in cutting steel and cast iron and their share in cutting and forming of non-ferrous metals, plastics, stone, coal and wood is still growing. Rockdrilling tools are used for mining, offshore oil, geological and civil engineering. The hardmetal industry is international with strong industries in Japan and N Ame
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Influence of radiative transfer on the structure properties and control of combustion fronts in participating media' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Despite the high sensitivity of burning-processes to temperature, and hence to energy exchanges, radiative transfer (R.T.) was often neglected, or handled in an averaged way, in treatments of combustion problems, due to its nonlinear, nonlocal, spectral and multidimensional features. Only recently did simplified models allow to take up the local and/or dynamical radiation- combustion couplings. Much remains to be done however. Our programme for a Post-Doctoral period at the ETSIA of Madrid (Prof. A.Linan) aims at improving our understanding of the influences of radiation/combustion interactions: - on the propagation of premixed flames in participating media and the nature of end products, - on the structure of tripple flames in mixing layers, - on the extinction of diffusion flames and pollutant formation.