RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GEM-SEE-Achro: Genomic Exploration—Mapping the Spread, Evolution, and Adaptation of an Emerging bacterial pathogen—Achromobacter' (GEM-SEE-Achro).

assistant: **Concept**

Achromobacter species are rapidly emerging Gram-negative opportunistic bacteria intrinsically resistant to several antibiotics and are often the cause of healthcare-associated infections, especially in individuals with compromised immune systems or underlying conditions. Following years of misclassification of Achromobacter spp. isolates combined with complicated species typing, the understanding of the ecology of Achromobacter spp. and their clinical significance is lacking. GEM-SEE-Achro aims to answer the questions regarding the population structure, evolution, adaptation, antibiotic resistance development, and genetic variability of Achromobacter spp. both globally and locally, providing crucial insights into the factors contributing to their prevalence, antimicrobial resistance patterns and potential novel therapy approaches. Analysis of whole genome sequencing (WGS) data allows to disentangle these questions. Therefore, I propose the largest Achromobacter spp. study to date including over 800 WGS encompassing its global diversity sampled from both the environment and infected patients. Employment of a number of bioinformatics analysis methodsgene content difference analysis; single nucleotide variant and mobile genomic element identification and association with population structure; evolutionary and migration rates analysis using Bayesian phylogenetics; and resistance phenotype association with genomic differenceswill help to answer the fundamental questions of how these bacteria evolve and adapt to their environment, what are the main differences in genetic composition between the environmental and clinical samples, and how these differences can inform us about the population structure and antibiotic resistance development in Achromobacter spp. The gained knowle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanism and targeting of topoisomerase regulatory interactions to arrest MYC-driven tumors' to be submitted under Horizon Europe.

assistant: **Abstract**

Inhibitors of DNA topoisomerases (TOPs, TOP1, TOP2) are mainstays of anticancer therapy. While they have proven effective, the toxicity of current TOP drugs, caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in clinic. Development of tumour-specific TOP inhibitors will require a better knowledge of the mechanisms of TOPs. This research program aims to define how TOP are regulated during transcription and replication and develop drugs that target these regulatory mechanisms for anticancer treatment.TOPs promote transcription and replication by removing DNA supercoiling generated during polymerase elongation. In my works published in Cell and Molecular Cell, I have discovered that the activity of TOPs in the cell is regulated. The oncoprotein MYC joins TOP1 and TOP2 in a topoisome complex and stimulates their activities to remove the supercoiling produced during transcription and replication, thus boosting cellular proliferation. Therefore, I propose that targeting the mechanism of the topoisome instead of the single TOPs, will selectively halt MYC oncogenic function while preserving physiological TOP activity, avoiding the generation of DNA damage associated to current TOP drugs. By using new genomic tools to analyse DNA topology, advanced biochemical and microscopy approaches, as well as drug screens, I will define the mechanism of MYC-driven transcriptional/replicational acceleration via topoisome assembly, and develop drugs blocking topoisome activity to arrest tumour growth. I predict this proposal is feasible based on my excellent background, compelling preliminary data, and strong collaborations with scientists at KI and National Institutes of Health. The work will identify novel strategies to target TOPs that can be put forward in clinic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Prognostics And Computer Aided Maintenance' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Aircraft System Prognostic solutions integrated into an airline E2E maintenance operational context.The key objective of the proposal is to demonstrate benefits of aircraft system prognostics solutions integrated into an airline E2E maintenance operational context. This will be achieved by development of following innovative components:• A novel prognostic architecture that includes both on-board and ground elements shall be demonstrated using a large passenger aircraft selected Aircraft System.• Specific prognostics capabilities such as data collection, data processing, symptom generation, failure mode identification and predictive trending shall be demonstrated within an advanced Integrated Health Monitoring and Management (IHMM) system.• A revolutionary augmented reality (AR) mobile tools as gesture recognition, speech recognition and near-to-eye (NTE) displays that aids maintenance execution by bringing the necessary information directly to the engineer at remote repair sites shall be developed and demonstrated.The primary impact of the proposed work shall be to maximize aircraft utilization and achievement of reduction in operational interrupts. We will achieve this by developing a framework allowing Airlines, MROs, OEMs, and Suppliers to share a common understanding of the diagnostic and prognostic health of the aircraft. This program leverages some of ongoing Honeywell work in the area of predictive analytics, connected aircraft architectures, and computer aided maintenance to achieve Large Passenger Aircraft IADP Platform work package 3.6 goals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Taylored designed ceria / zirconia mixed oxides for the new generatio n of twc-like environmental catalysts' under Fourth Framework.

assistant: **Concept**

This Project is aimed at developing an in-depth basic research program on post-doctoral researchers among the Laboratories involved. The experience the textural, chemical, and nanostructural properties of ceria/zirconia mixed oxides (CeZrMO), and CeZrMO supported noble metal model catalysts. of these Laboratories in the field of TWC's, as well as the excellence level they have achieved in a large variety of chemical, spectroscopic, From our results, the next generation of Three Way Catalysts (TWC's), the nanostructural and catalytic testing techniques will give the young one fitting the requirements established in Phase 3 (1999) of the EU scientists an unique opportunity of being trained by Research Teams Regulation on the exhaust emissions from motor vehicles, would be designed occupying leading positions in their respective expertises. on much firmer scientific basis. Our Project brings together Rhone-Poulenc, one of the largest world producers of rare earth oxides, as well as eight academic teams, with a long previous experience in the field, and reputated expertise in very powerful, highly complementary experimental techniques. The application of such a battery of techniques in the framework of a Joint Research Program with common well defined targets, and standardized experimental procedures would highly potentiate the intrinsic usefulness of any individual project to be developed on the subject.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A disruptive technology that enables low cost real-time monitoring of road pavement condition by any ordinary vehicle circulating on the road, and automatically designs plans for predictive maintenance.' (PAV-DT) targeting Horizon 2020.

assistant: **Abstract**

Despite the huge public budget effort (6.000M€/year) for road pavement maintenance, the European road network (5.5M km) is not in an acceptable condition. Current pavement maintenance strategies are mainly based on corrective maintenance which is an inefficient and costly approach, with negative impact on pavement service life and road safety, and also on the environment. In order to be able to implement a maintenance strategy based on preventive operations of much lower cost carried out at the optimal moment (predictive maintenance), it is necessary to have continuous and accurate information of the pavement condition, something that is not possible at present due to the high cost of current inspection services. PAV-DT is a disruptive technology that can be installed in any customer vehicle (e.g. public road administrators and concessionaires or construction companies on performance-based maintenance contracts) in order to convert these vehicles into a very low-cost real-time pavement inspection equipment through its ordinary circulation. Additionally, thanks to our advanced algorithm and a cloud-based platform, customers will be able to access the latest available information on the pavement condition at any moment  and receive information on which maintenance actions are really required, and exactly where they should be applied and when is the best moment to deploy a truly cost-effective maintenance strategy.  PAV-DT consortium formed by APPLUS (Spain), BECSA (Spain), M&S (Austria), MICRO-SENSOR (Germany) and IMM-UPV (Spain)  agreed on creating a Joint Venture for the commercial exploitation of the results as soon as the project is completed through a Product-as-a-service business model. Revenues of more than 38.8M€, with an associated profit of 25.5M€ and the creati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nano-based Anti-Tarnishing Technology for Precious and Non Precious Metal Protection'.

assistant: **Objectives**

In the jewellery, silverware and most generally in the precious metal industry sectors, product protection from tarnishing is a constant consideration. Seen as a cosmetic discoloration (i.e. black areas on metal surfaces), tarnishing is the cause of a major economic impact in those sectors. By modifying the appearance of precious metal products, it greatly diminishes their value. To counter the effect of tarnishing, different anti-tarnish approaches have been taken so far to solving this problem. However, none of them satisfies the need of precious metal product manufacturers that are still in need of innovative technologies to protect their precious metal product. During the last two years, we, AGERE, have been working on the development of an advanced nano-molecular based technology, called Nano-SHINE, that perfectly addresses the need of innovation in those sectors where precious metal appearances are of the utmost importance to appeal consumers. Nano-SHINE is a unique and patented solution. It is the only cost-effective treatment that protects precious metals from tarnishing with no impact on appearance. Being a molecular protective layer, brightness and colour are not affected. Not only does Nano-SHINE maintain the product quality intact, but also it enhances the wear resistance of the component, so as materials do not get old and remains shining bright for years. We are already working with more than 40 customers today and we have approached over 200 potential customers worldwide that are currently testing our solution. We believe that the Nano-SHINE project is the step that will fulfil our objective aiming at the full deployment and industrialization of our technology. Over time, we expect to provide a significant breakthrough in the field of anti-tarnishing tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Logistics for Manufacturing SMEs' (L4MS).

assistant: **Concept**

L4MS (Logistics For Manufacturing SMEs) will spark incremental (productivity increase of new users by a factor of 4 and system setup time reduction by a factor of 10) and disruptive innovation (batch size one & consumerization) for over 100,000 European Manufacturing SMEs & Mid-Caps, building on their intra-factory logistics challenge (50% of the production cost of an item) unleashing their digitalization potential by powering new robot systems that are more cost effective at lower lot sizes.L4MS relies upon:• An open industrial IoT platform with enablers for rapid and efficient deployment of customized logistics solutions.• A suite of ""Smartization services"" including business modelling, technical support, mentoring, access to skills and to finance.• The L4MS Marketplace, a one-stop-shop, where European Manufacturing SMEs & Mid-Caps will access the L4MS services.• A portfolio of 23 cross-border Application Experiments by 50 SMEs selected through 2 competitive Open Calls, that will test more than 40 services & apps leveraging 10M€ of public funding across 12 established and emerging Digital Innovation Hubs.• A growing ecosystem that will foster Smart Specialization in each single region linked to L4MS.L4MS will transform a pan-European ecosystem into a self-sustainable start-up operating an Open Platform for Innovations in Logistics (OPIL) and L4MS marketplace consisting of 21 members. Comprising 6 Competence Centres, 5 technology providers, 4 industry associations, 3 end-users and 3 business developers -currently engaged in I4MS (XS2I4MS, HORSE and BEinCPPS) and FIWARE- plus 6 Satellites Nodes. L4MS covers 14 EU countries, 15 regions with 8 of them from East Europe.L4MS will help demonstrate that public funded research with a “Smartization” approach (accelerating Ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards Richer Online Music Public-domain Archives' under Horizon 2020.

assistant: **Concept**

Classical music is one of the greatest treasures of Europe’s cultural heritage. Although a historical genre, it is continually (re)interpreted and revitalised through musical performance.Today, most of the classical repertoire is in the public domain; massive numbers of scores and recordings are now available in online community-contributed repositories actively used by scholars and musicians. Technology offers ways to enrich and contextualise this repertoire, so that users might better understand and appreciate it. However, due to varying data quality and scale, this does not happen automatically for public-domain resources.  Amidst a deluge of data, relevant associations across repositories and modalities (e.g. from scores to recordings) still have to be made manually, while insights by previous users are not explicitly stored for future users to learn from. It is thus impossible to get comprehensive insight into the full wealth of our musical cultural heritage.TROMPA will change this by massively enriching and democratising our publicly available musical heritage through a user-centred co-creation setup. For analysing and linking music data at scale, the project will employ and improve state-of-the-art technology. Music-loving citizens (including the large scene of amateur performers) will cooperate with the technology, giving feedback on algorithmic results, and annotating the data according to their personal expertise.Following an open innovation philosophy, all knowledge derived will be released back to the community in reusable ways. This enables many uses in applications which directly benefit crowd contributors and further audiences. TROMPA will demonstrate this for music scholars, content owners, instrumentalists, choir singers, and music enthusiasts. Via the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Action Potential Dynamics in a Lipid Nanotube - A Minimal Model of the Neuron' (ARTIFICIAL-NEURON).

assistant: **Concept**

The active propagation of electrochemical signals is widespread in biological organisms because of the need for efficient, rapid communication. Open questions about signaling remain because experiments with actual neurons are constrained by the neuron’s complex structure and intricate feedback. The goal of this project is to develop a minimal model of the neuron in which the active propagation of electrochemical signals can be readily studied. A Giant Unilamellar Vesicle (GUV) containing voltage-gated potassium channels will serve as the “soma” for this synthetic neuron. A long, membrane tube will be drawn out from this GUV to form an “axon”, and signal propagation along it studied with electrophysiology and fluorescence techniques. Predictions about the fundamental limits of biological signaling will be tested by measuring the speed and fidelity of the action potential as parameters including the diameter of the membrane tube, resting membrane potential and density of ion channels are varied. As intermediate goals, we will determine if membrane curvature induces protein sorting, and will also study how the shape and fluctuations of the GUV membrane are coupled to the activity of the ion channels. This project will contribute significantly to our understanding of active membranes and action potential dynamics. In the future, the skills and techniques learnt during the project may be applied to other complex processes such as signaling in networks, pacemaker activity and signal amplification cascades.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Green Innovations in Hydrogen for Sustainable Energy Transition' (H2START), addressing dissemination and exploitation.

assistant: **Impact**

The H2START project aims to establish a Centre of Excellence (CoE) in Stara Zagora to spearhead the advancement of innovative technologies for renewable hydrogen production and uptake. As an essential component of the transition towards a low-carbon and energy-secure economy, renewable hydrogen holds tremendous promise for Bulgaria, particularly in regions like Stara Zagora, historically developed as the energy production “heart” of the region, economically developed and well connected to infrastructure and trans-European roads.The CoE, situated in the heart of Stara Zagora, is strategically positioned to lead the change in replacing coal mining with renewable energy and green hydrogen production, deployments and export. Recognised as a Hydrogen Valley by the Clean Hydrogen Partnership (ZAHYR HV), the region's successful transformation hinges on excellence (R&I activities, attracting talents and gaining recognition and international collaboration). Led by TrU and supported by BGH2A, the CoE aims to drive R&I initiatives, which will bring institutional change to the higher education sector in the whole system opening up to reforms linked to creating highly skilled employment opportunities, and positioning Bulgaria as an attractive hub for scientific and technological advancement. Collaboration with esteemed partners such as POLITO and CNR alongside the guidance of international recognized leaders, will ensure robust governance, management, and administration systems.The CoE will revolutionize Bulgaria's research ecosystem, offering modern infrastructure and services to attract, nurture, and retain research talent while fostering collaboration with industry for enhanced innovation and technology transfer. As Bulgaria's research infrastructure outside of the capital Sofia,