RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Governing Health, Family and Religion: The Biopolitics of Genetic Counselling and Religious Family Formations' to be submitted under Horizon Europe.

assistant: **Abstract**

RELI-GENE is an interdisciplinary project which examines minorities’ attitudes towards genetic counselling and reproductive options in the case of inherited genetic recessive disorders and analyses how healthcare policies govern communities’ family formations. It focuses on close-knit religious minorities that emphasise consanguineous and endogamous marriages to strengthen communal bonds to provide a sense of solidarity and of safeguarding lineage and purity. Current scholarship focuses predominantly on single national contexts, specific healthcare policies and individual religious communities, neglecting comparable perspectives. RELI-GENE specifically analyses how transnational spaces serve as strategies to navigate and bypass national healthcare policies and legal restrictions related to marriage and reproductive practices. The project adds a new conceptual framework to understanding (a) the broader implications of directive, nondirective and mandatory genetic counselling within diverse national healthcare systems; (b) communities’ own use of biopolitics to construct discourses around lineage and purity; (c) how individuals respond to both state policies and to the religio-cultural norms and expectations within their communities.RELI-GENE offers a perspectival shift on the governmentality and biopolitics of family formation by1. examining the different forms of power in state-led biopolitics in Israel and the United Arab Emirates, Sweden and Germany and their respective healthcare systems, 2. exploring communities and their transnational links which for religious, cultural and political reasons manifest a biopolitics of purity and examining how these communities construct lineage-oriented narratives to counter their minority status or sense of persecution and marginal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Automated real-time production forecasting for industry'.

assistant: **Concept**

"Workshop managers face daily the challenge to execute their production plans at the lowest product rejection rates and costs. Rejections can be due to multiple kinds of defects in the manufactured piece. Each kind of defect is co-related to the particular parameters of production and the surrounding environment that have converged during the manufacturing process of the defective piece. At modern workshops the number of converging parameters during production can range from several hundreds to thousands. In serial production, defects are more prevalent at the beginning of the production of each new reference, until all production parameters are correctly set-up, but it’s also frequent to suffer involuntary, environmental or unavoidable modifications of parameters that also cause defective production.The problem of defective production is particularly relevant the higher the value of the workpieces produced and the shorter the production series. The evolution of the industrial production worldwide, and specially in advanced economies like Europe, tend towards a higher customization of products, thus to shorter series of higher cost and value pieces, making the problem of defective production a increasingly relevant issue for the competitiveness of industry.VEIGALAN has developed WORKSHOP4.0, a tool based on big data and artificial intelligence technologies that forecasts in real time the optimum working conditions for production processes involving material melting or fluency. WORKSHOP4.0 is capable to forecast the optimum production parameters at the beginning of a new series and re-calculate the new optimum parameters when unexpected, even un-noticed, defect producing events happen.""""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Generic open link-layer API for unified Media Access' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The GOLLUM project aims at studying and creating key parts of an embedded, open, operating system independent link-layer API to unify the various methods for accessing different wired and especially wireless links. The aim is to remedy the current, very difficult situation where a separate programming interface exists for almost every wireless technology. The existence of such an API and corresponding middleware would greatly improve interoperability between various technologies. It would enable better portability of applications between devices using different, usually wireless, communication interfaces. The GOLLUM API is aimed to simplify the wireless access programming as seen by programmers, and same time providing more flexibility and new features for innovative application.This would potentially enable operators and software vendors to provide new kinds of services and greatly enhance the user experience. Applications could properly adapt to changes in the network connection, allowing for smart applications to be developed. An API of this type is also a building block for middleware and embedded systems for intelligent, networked devices. The project will provide not an openly available API specification, but also is doing practical, partial prototype implementations on various commercially viable technologies and different operating systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing a novel Parkinson's disease drug using small molecule mimetics of Glial cell line-Derived Neurotrophic Factor (GDNF)', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

GeneCode is developing a novel anti-PD drug that contains a central nervous system penetrant compound imitating GDNF peptide pathway activation that alleviates both motor and non-motor symptoms in PD patients, protecting and restoring lesioned dopamine neurons as well as potentially increasing dopamine levels in brain tissue. GeneCode’s unique solution uses small-molecule compounds that penetrate the blood-brain barrier, target the GFL receptor complex (containing GDNF protein) and mimic GFL (GNDF family of ligands) biological effects in neurons, promoting survival in the affected dopaminergic neuronal pathways. Once fully developed, the PD drug would be administered weekly or less frequently as an oral treatment. Considering the importance of GDNF family ligands and/or RET-signalling pathways for other groups of cells, applications of compounds developed by GeneCode are not limited to PD, but can be applied to cure other medical conditions such as neuropathic pain, addiction, ALS etc.


**Keywords:** Neurodegeneration,IND-enabling studies,Glial cell line-Derived Neurotrophic Factor ,Small molecule mimetics ,Central nervous system,Parkinson's disease,Neurochemistry and neuropharmacology,Biotechnology,GFL receptor complex ,Drugs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Noves methods for controlling zinc in mine effluents' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

There is a pressing need for SMEs active in mining to develop simple, inexpensive methods for removing eco-toxic metals from mine effluents. One particularly problematic metal is zinc, which is currently difficult to remove from neutral-pH effluents at reasonable cost. Zinc is particularly a problem in the effluents from lead-zinc and/or fluorspar mines, many of which are now worked by small, local SME mining companies, which are vital sources of local employment, and yet too small to maintain their own RTD capacity. This project aims to devise some simple, reliable approaches to minimise zinc impacts from such mines by developing strategies including (i) diversion and storage of zinc-rich waters within mine voids until such time as flows in receiving streams are high, and (ii) passive treatment of effluents in simple gravity-feed geochemical reactors, using one of three possible new approaches (co-precipitation with calcite, sorption onto ochre, anaerobic sulphate reduction in the presence of organic acids).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evolution of Mechanisms for Sex Chromosome Dosage Compensation and Gene Regulation' under Horizon Europe.

assistant: **Concept**

There is a remarkable diversity of phenotypes among multicellular animals, including differences between males and females. A major driver of phenotypic variation stems from differences in gene regulation. The evolution of these regulatory mechanisms is a central, yet unresolved question in biology. Sex chromosome dosage compensation (SCDC) is an epigenetic process that equalizes sex chromosomal gene expression between males and females. EMERGE uses SCDC as a model to uncover how and why epigenetic mechanisms evolve and function across animals. We will employ a taxonomic gradient from (1) molecular studies in malaria mosquitos to (2) comparative mechanistic analyses across multiple insects, and finally to (3) a broad investigation across all animal clades. First, we will determine how a novel SCDC pathway in malaria mosquitos evolved to specifically regulate the X chromosome. To achieve this, we will use heterologous expressions, alongside in vitro biochemistry and proximity proteomics. Second, we will assess the physiological relevance of SCDC to determine why its absence is lethal in only certain contexts and species. We will test how proteome homeostasis, transcriptional noise, and critical genes influence essentiality. Third, we will explore the diversity of SCDC mechanisms across dozens of animal species with heteromorphic sex chromosomes, including unexplored phyla such as Cnidaria or Mollusca. Employing microscopy, transcriptomics, proteomics, and epigenome profiling, we will study SCDC patterns, conserved and lineage-specific adaptations, as well as regulatory mechanisms. Our findings are expected to reveal general principles of how chromatin controls gene expression, responds to dosage imbalances, and evolves across the animal tree of life. By comprehensively i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Accelerating Digital Innovation in Schools through Regional Innovation Hubs and a Whole-School Mentoring Model' in the context of a Horizon 2020 call.

assistant: **Objectives**

iHub4Schools will propose mechanisms to accelerate whole-school digital innovation in and across schools through establishment of Regional Innovation Hubs. Our aim is to support a minimum of 75 European schools and 600 teachers to implement project approaches by establishing regional innovation hubs as sites of establishing and multiplying school-to-school mentoring structures. This will be achieved, firstly, through different support mechanisms that will focus on supporting the collaboration between digitally advanced and less advanced teachers and schools through a variety of peer learning approaches and engagement structures. Secondly, iHub4Schools will develop a whole-school mentoring model that is locally, methodologically and technologically adaptable. It embraces both inter- and intra-school levels, and integrates a continuous monitoring methodology by including novel evaluation approaches and the Learning Analytics Toolbox.  Regional Innovation Hubs will be established in 5 European countries and the mentoring model will be piloted with 600 teachers in 75 schools. Long-term sustainability will be ensured by a systematic stakeholder engagement strategy that will integrate initiatives and partners on a local level, such as local municipalities, school boards, teacher associations and network, for these activities to be carried out on the long term. Regional impact will be sustained by the upskilling of the teachers to implement technologies meaningfully to teaching and school heads to scale and sustain the innovation in and across the schools.


**Keywords:** whole-school mentoring, evidence-informed decision making, school improvement, co-creation, regional innovation hubs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'millimeter Wave Channel Modelling Considering Environmental Factors' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The Millimetre-wave (mmWave) frequency band offers wide available bandwidth for 5G and future wireless networks. However, due to the large propagation attenuation of the mmWave frequency, real-world environmental factors, including weather, foliage, humans, vehicles, have a significant impact on the channel path loss. In order to design and optimise 5G and future networks, a mmWave channel model considering the environmental factors is urgently required. In this project, we aim to equip a ray-tracing channel model with environmental factors in the mmWave band. The goal will be approached through 3 work packages (WPs). First, the ER will develop a parametric attenuation model by parameterising the environmental factors and integrate it with a ray-tracing simulation model. Second, the ER will acquire the channel data for each corresponding environment factor and extract parameters using machine-learning-based methods. Third, the developed channel model will be applied to evaluate and optimise mmWave wireless networks taking environmental factors into account. This project will be an extension of the ER’s previous work, which will develop him to be a mature researcher.


**Keywords:** Millimetre wave, Channel modelling, Propagation modelling, Channel measurement, Machine learning, 5G, 6G
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MIcrobially MEdiated Particulate Organic Carbon flux' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Particulate organic carbon generated by primary production in surface waters is exported into the ocean’s interior through the biological pump, contributing to the regulation of atmospheric carbon dioxide and partial sequestration of ocean carbon. Microbial transformation mechanisms on sinking aggregates directly impact the quantity and quality of organic matter reaching the deep sea. Due to their importance in biogeochemical cycles, sinking particles and their microbial components have received increasing attention in the past few years. However, microbial interactions and mechanisms involved in particle formation and degradation remain largely unexplored. The overarching goal of the current project is to explore for the first time the specific functions of particle-associated prokaryotes in determining the fate of sinking particulate organic matter (POM). First aim is to investigate in situ the RNA-based functional and genomic characteristics of sinking particle-attached microbes over time at different depths, using metatranscriptomics and metagenomics analyses. We also aim to elucidate the protein-based functional profiles of microbial communities on sinking particles and uncover linkages between microbial enzymes involved in the degradation of POM, using a comparative metaproetomics and metagenomics approach. Additionally, we aim to examine the carbon uptake, metabolic activity and colonization patterns of sinking-particle-attached microbes, using stable isotope probing coupled with amino acid tagging and liquid chromatography mass spectrometry. It is anticipated that the insights provided into microbially mediated processes regulating POM transformation will set the basis for better understanding the oceanic carbon cycle, and further improve predictions on future o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The life-cycle of stars and galaxies' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Marie Curie Fellowships at the Netherlands Research School for Astronomy NOVANOVA is a federation of the astronomical institutes at the Universities of Amsterdam, Groningen, Leiden and Utrecht, with a research program focused on:* Formation and evolution of galaxies: from high red shift to the present;* Birth and evolution of stars: the life-cycle of gas and dust;* Final stages of stellar evolution: physics of neutron stars and black holes. The program involves development of new instruments for the ESO VLT, the ESO-VLTI, and the Atacama. Large Millimeter Array, the Westerbork Synthesis Radio Telescope, and for Laboratory Astrophysics. Interested candidates should send a curriculum vitae and publication list, a brief description of their research experience and interest, as well as two letters of recommendation to the NOVA Office. They may also wish to indicate which of the NOVA institutions (further information on our website) they prefer as training site. Modern astronomy requires a broad range of skills. Knowledge of physics and mathematics is a prerequisite. Marie Curie Fellows will learn to cope with practical limitations of real data, to develop algorithms for handling data imperfections, to pan and carry out observations on international facilities, to work effectively in international collaborations, and to carry out numerical simulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Saponinases in fusarium oxysporum - gene regulation and role in phytopathogenicity' (1994-1998).

assistant: **Concept**

Fusarium wilts caused by different formae speciales of the soilborne phytopathogenic fungus Fusarium oxysporum provoke severe yield losses on many crop plants in Europe and world-wide. A better understanding of the molecular mechanisms controlling pathogenicity is needed in order to improve disease control strategies. Saponins are common plant secondary metabolites occurring in over 100 families including many major food crops. Many of them have pronounced antifungal properties, and it has been proposed that they act as pre-formed determinants of resistance to attack by fungi. Some pathogenic fungi have intrinsic resistance to the membranolytic action of saponins because of their membrane composition, whereas other produce enzymes (saponinases) that specifically detoxify particular plant saponins. These enzyme activities have been associated with the ability to attack certain plants. The saponin alpha-tomatine, found in tomato plants, is toxic to a broad range of fungi. Fusarium oxysporum f.sp. lycopersici, a tomato pathogen, produces an extracellular enzyme, known as tomatinase, which catalyses the hydrolysis of alpha-tomatine into its nonfungitoxic forms, tomatidine and beta-lycotetraose. The aim of this project is to determine the significance of tomatinase in the pathogenicity of Fusarium oxysporum f.sp. lycopersici to tomato. The specific role of tomatinase in this plant-pathogen interaction will be first assessed by studying tomatinase-minus fungal mutants generated by targeted gene disruption and overproducing strains with constitutive expression of the tomatinase gene. Additionally, a reporter gene system will be used to analyse the mechanism by which tomatinase expression is regulated in vivo during the process of infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Dissolution reactions at the mineral-aqueous solution interface'.

assistant: **Innovation**

The purpose of this proposal is to use accurate first-principles quantummechanical methods to study the reactions of aqueous fluids with simple mineral surfaces at the atomic level. I aim to describe and quantify the surface reaction mechanisms taking part in the dissolution of CaCO and CaO. The calculations will examine both physisorption and dissociative 3 chemisorption of H20 molecules, H O and OH ions both on the perfect cleavage surfaces and defective surfaces. Plane-wave pseudopotential calculations conducted on workstations and supercomputers will allow a realistic model of the fluid/surface environment. The computations will yield accurate predictions of adsorption and dissociation enthalpies, and activation energies for the detachment reaction, and help to explain the factors influencing the kinetics of dissolution.