RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Eastern enlargement of the european union: lessons from the spanish experience' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The forthcoming enlargement of the European Union (EU). Which will encompass, among others, ten Central and Eastern European countries, is both an opportunity and a challenge of unprecedented proportions. This project consists on analyzing how both the European Union (EU) and Central and Eastern European Countries (CEEC's) should prepare for, and successfully undertake, European Union enlargement. The research will be centred on one dimension of the EU enlargement towards the East of Europe that have received less attention in the economic literature: the CEEC'S can profit from the Spanish experience, taking into account that there are similar characteristics between these countries and Spain before its adhesion. Thus, the research project will analyze the relative structural costs that candidate countries will probably support, comparing the economic situation of these countries with that of Spain prior to its adhesion. The results of the research will be used in a seminary on EU enlargement and will be included in a web page entirely devoted to this topic. Besides, the co-operation between the CUREI and a professor of a well-known Spanish university will foster intra-Europe scientific dialogue on compared political and economic issues. The variety of the available supervisors within the CUREI staff and the interdisciplinary composition of the groups. allow to introduce the applicant into other fields, like political science and law, very connected with the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bioproduction of pharmaceutically important iridoids: systems biology based approach' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Plant in vitro technologies have been known for more than century. During this time, plant cell, tissue and organ cultures have become increasingly attractive and cost-effective alternatives to classical approaches for the mass production of plant metabolites. Furthermore, plant in vitro systems are the only economically feasible way of producing some high-value metabolites from rare and/or threatened plants. The progress in this field has resulted in the mass production of several important metabolites, such as taxol (paclitaxel), shikonin and berberine by different companies. However, for their production several problems had to be overcome, mainly connected with their cultivation in vitro and high sensitivity to different stress factors/conditions. Today in the postgenomic era, new functional genomic tools (transcriptomics and proteomics), enabling comprehensive investigations of biological systems, are continuously further developing and are gradually being implemented in the field of plant secondary metabolism. The latest of the “omics” is metabolomics, which is now combined with the other “omics” and such a holistic functional genomic approach forms systems biology, in which the synergism of this powerful combination opens novel avenues to fully explore the total biochemical machinery of plants. The general objective of the scientific project is to evaluate the systems biology based approach for bioproduction of pharmaceutically important iridoids from difficult-to-access and endemic Bulgarian plant species. This includes transcriptomic analyses, metabolomics and assessment of biological activities. The metabolic engineering aspects will be also covered through gene/multigene transformations. The project will finally seek for development of technology platform for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Political integration, special interests and growth' (POLINT) targeting Sixth Framework.

assistant: **Abstract**

Does political integration affect long run growth? While there is a large literature on the effects of economic integration on the economic performance of countries, this question has received little attention.The objective of this research is to provide a theory that links political integration between previously independent countries to economic growth. The project is to build an endogenous growth model in which technological progress creates a conflict between groups that benefit and groups that lose from innovations.Economic policy influences the extent of technological advances. Interest groups lobby the government and affect technological progress and growth. Under political integration, countries form an international union and delegate to a union government relevant economic policy prerogatives.This shift in jurisdiction changes the size of the political market and the extent of competition for political influence between special interest groups. Through this channel political integration affects t he equilibrium policy, technological progress and long run growth.The methodology proposed in this research is innovative: the relationship between special interests and the policymaker will be modelled as a (dynamic) common agency game.Moreover, lobby formation can be studied as an endogenous decision of interest groups. By focusing on the political economy of growth in an international union, this project wants to contribute to the ongoing research on a growth agenda for Europe.In particular,- it will shed light on relevant political constraints that limit growth in the EU;- it will provide a formal framework to think about policy implications and institutional solutions to deliver higher growth in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bioactive Nickel Titanium Shape Memory Alloys for Enhanced Osseo-integration' under Sixth Framework.

assistant: **Concept**

The near equiatomic intermetallic nickel titanium (NiTi) has remarkable properties. It is a shape memory alloy that exhibits considerable super-elasticity. Super-elastic NiTi is of special interest as it has elastic properties which are far closer to bone than conventional metallic materials. Although concerns have been expressed regarding the high quantity of potentially toxic nickel in the metal; a wide range of studies have shown that nickel release from these alloys is low and poses little risk to patients.The biocompatibility of NiTi is attributed to the formation of a highly corrosion resistant titania surface film. In recent years considerable research has been carried out into mechanisms for increasing the biocompatibility of titanium by modifying the surface chemistry of the metal to enhance the growth of hydroxyapatite phases on the surface. It has been shown that a wide variety of surface modification techniques may be employed to this end.This proposal aims to extend the work carried out on Ti to NiTi surfaces. The modification procedures proposed are combined alkali and heat treatments and calcium ion implantation. It is vital that any surface modification does not compromise the passive titanium oxide film resulting in increased ion release. Therefore, it is proposed to monitor the properties and form of the oxide film using X-ray photoelectron spectroscopy (conventional and depth profiling), secondary ion mass spectrometry (static and dynamic), white light interferometry, goniometry and ion-chromatography. Bioactivity of the resulting surfaces will be assessed by measuring the ability to precipitate calcium phosphates from simulated body fluid and the performance of osteoblast cells on the surfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Concerted Action for European Transport Information Systems' (CONCERTO).

assistant: **Concept**

CONCERTO project is part of the Information Systems programme (3rd call) and has three primary objectives:- to enable and to promote the concertation activities of tasks in the domain Information Systems and in other research fields of the 4th Framework which relate to Information gathering and manipulation,- to provide the technical support for the organisation and the follow-up of Concerted Action Committee (CAC) meetings,- to take care of the dissemination of results of activities in the field of Strategic research and- to promote the development of an European Transport Policy Information System (ETIS), linking research to policy making.The organisation of the CAC meetings in the context of CONCERTO are aiming at fulfilling two objectives:- to provide the members of the Committee with a state of the art of projects in the domain of Information Systems or those which are strongly related to this subject matter,- to present some general issues which contribute to the process of developing an ETIS system. %NoneIn CONCERTO no case studies are foreseen.It is intended to develop a website support of the dissemination of information assessed by CONCERTO; this website will be used as a bridge for the administrations and researchers to access other RTD projects in the filed of Information Systems. %To ensure a link with and between other projects is a core activity of CONCERTO. The role of CONCERTO as a sort of catalyst of exchanges and dissemination of Information is illustrated in the figure below.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ATOMic Insight Cavity Array Reactor' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of ATOMICAR is to achieve the ultimate sensitivity limit in heterogeneous catalysis: Quantitative measurement of chemical turnover on a single catalytic nanoparticle.Most heterogeneous catalysis occurs on metal nanoparticle in the size range of 3 nm - 10 nm. Model studies have established that there is often a strong coupling between nanoparticle size & shape - and catalytic activity. The strong structure-activity coupling renders it probable that “super-active” nanoparticles exist. However, since there is no way to measure catalytic activity of less than ca 1 million nanoparticles at a time, any super-activity will always be hidden by “ensemble smearing” since one million nanoparticles of exactly identical size and shape cannot be made. The state-of-the-art in catalysis benchmarking is microfabricated flow reactors with mass-spectrometric detection, but the sensitivity of this approach cannot be incrementally improved by six orders of magnitude. This calls for a new measurement paradigm where the activity of a single nanoparticle can be benchmarked – the ultimate limit for catalytic measurement.A tiny batch reactor is the solution, but there are three key problems: How to seal it; how to track catalytic turnover inside it; and how to see the nanoparticle inside it? Graphene solves all three problems: A microfabricated cavity with a thin SixNy bottom window, a single catalytic nanoparticle inside, and a graphene seal forms a gas tight batch reactor since graphene has zero gas permeability. Catalysis is then tracked as an internal pressure change via the stress & deflection of the graphene seal. Crucially, the electron-transparency of graphene and SixNy enables subsequent transmission electron microscope access with atomic resolution so that active nanoparticles
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Determination of molecular dynamics in membrane proteins and protein fibrils using novel solid-state NMR methods' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Structural data obtained from X-ray crystallography as well as from NMR spectroscopy has clearly provided evidences that many proteins have intrinsic disorder either locally or globally. Emerging evidence suggests that these small or large-scale deformations occur at various time scales and provide important hints for the regulatory mechanisms of the proteins. In this view protein plasticity is becoming an important parameter for molecular organization and recognition. In this project, we aim to probe the molecular dynamics of membrane proteins and protein fibrils at residue level and atomic detail using novel solid-state NMR methods. Using a combination of NMR pulse schemes that probe relaxation and anisotropic interactions in a residue-specific level, our goal is to understand the molecular level assemblies of fibril proteins and various intermediate states of the fibrilization process. The same methods will be used to elucidate the protein plasticity when embedded in lipid bilayers, providing novel possibilities to probe signaling and cellular uptakes in a functional state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Thermodynamic investigation of magnetic field induced quantum phase transitions'.

assistant: **Objectives**

The central objective of the present proposal is to improve our understanding of quantum phase transitions and related emergence of novel quantum phases, such as unconventional superconductivity or Bose-Einstein condensation of magnetic excitations observed in heavy fermion compounds, quantum spin systems, and antiferromagneti molecular wheels.The proposed project will address this matter via an experimental study of the low-temperature thermodynamic properties of ferromagnetic superconductors URhGe and UCoGe, magnetic insulators SrCu2(BO3)2 and BiCu2PO6, and molecular nanomagnets Fe18 and Mn-[3x3]. In all cases, high magnetic field will act as a tuning parameter to bring systems to a quantum critical (end) point. A state-of-the-art experimental set-up for heat capacity measurements at high magnetic field up to 35 T and very low temperature down to 100 mK will be built to achieve the project goals. Ultimately, this technique will become available to the European scientific community via an access to the Grenoble High Magnetic Field Laboratory, a European user facility and the host laboratory for the project.Through the completion of the project, the applicant will acquire a broad range of scientific and technical abilities while establishing herself in the field of condensed matter research corresponding to her interests. The training and visibility thus gained will promote the professional maturity and insertion of the applicant on her path to become an independent researcher. In turn, the research will be beneficial to the host institution and will contribute to the advancement of European science. It will add considerably to our knowledge and understanding of the newly emerging physics of quantum phase transitions.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Universal Equation for Non Equilibrium Correlations in Interacting Particle Systems' to be submitted under Horizon Europe.

assistant: **Abstract**

An open system out of equilibrium exchanges matter, energy, or information with its surroundings through directed currents that break time-reversal symmetry. Far from equilibrium, the arrow of time becomes crucial. While equilibrium physics is well explained by statistical physics, understanding non-equilibrium systems is a major challenge in modern physics. Do universal laws exist far from equilibrium? How can complex systems’ dynamics be characterized?Interacting particle systems (IPS), driven by external fields or prepared with an initial inhomogeneous density profile, are the “hydrogen atom” of non-equilibrium physics. Very recently, we have made important progress for the Symmetric Exclusion Process (SEP), a paradigmatic model of one-dimensional IPS, and showed by relying on a novel approach that this many-body dynamics in fact reduces to a simple single-body exact closed equation for the correlations, which can be solved explicitly. Beyond the particular case of the SEP, this striking but puzzling result changes our views and opens new horizons in the analysis of IPS by reducing them to single-body problems. Unveiling the corresponding universal closed equation for correlations in general IPS, along with the underlying theoretical framework of non-equilibrium statistical physics, is the objective of this project. The achievability of this challenging task is supported by promising recent developments both for diffusive systems (which obey Fick’s law) and for ballistic systems. These results will provide explicit characterization of transport properties in general IPS, conceptually new tools to analyse interacting particle systems and finally resolve the long-standing challenge of formulating a general framework for non-equilibrium statistical physics.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Revealing Allele-level Regulation and Dynamics using Single-cell Gene Expression Analyses' (2014-2020).

assistant: **Concept**

As diploid organisms inherit one gene copy from each parent, a gene can be expressed from both alleles (biallelic) or from only one allele (monoallelic). Although transcription from both alleles is detected for most genes in cell population experiments, little is known about allele-specific expression in single cells and its phenotypic consequences. To answer fundamental questions about allelic transcription heterogeneity in single cells, this research program will focus on single-cell transcriptome analyses with allelic-origin resolution. To this end, we will investigate both clonally stable and dynamic random monoallelic expression across a large number of cell types, including cells from embryonic and adult stages. This research program will be accomplished with the novel single-cell RNA-seq method developed within my lab to obtain quantitative, genome-wide gene expression measurement. To distinguish between mitotically stable and dynamic patterns of allelic expression, we will analyze large numbers a clonally related cells per cell type, from both primary cultures (in vitro) and using transgenic models to obtain clonally related cells in vivo.The biological significance of the research program is first an understanding of allelic transcription, including the nature and extent of random monoallelic expression across in vivo tissues and cell types. These novel insights into allelic transcription will be important for an improved understanding of how variable phenotypes (e.g. incomplete penetrance and variable expressivity) can arise in genetically identical individuals. Additionally, the single-cell transcriptome analyses of clonally related cells in vivo will provide unique insights into the clonality of gene expression per se.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A study to establish the technical and economic feasibility of a mobile DNA and RNA testing tool, for use in general clinics and homecare.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

As DNA testing is most commonly centralised in labs, it lacks the turnaround time for time-sensitive applications, and also lacks mobility. The experience in biology required to prepare samples and carry out testing obfuscate the process and limit point-of-care applications. Biomeme seeks to break down these barriers with their versatile Dx System, a holistic solution to bring DNA testing out of the labs and into the physician’s office. Thus, Biomeme provides Molecular Diagnostics for the on-demand economy. By simplifying the process of DNA testing, without sacrificing the detail to be found in raw data, the Biomeme solution brings molecular diagnostic into point-of-care medical services, making it available for homecare and other point-of-need uses.