RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Electroanalysis of metals and sulfide in natural waters using microelectrodes'.

assistant: **Concept**

Electro detection of metal and sulphide species in natural waters using microelectrodes. Metal and sulphide species can be detected in natural waters using electrodes, usually mercury based but some success has been obtained using modified electrodes. In-site detection in surface waters, and especially pore waters of sediments, is severely hampered by lack of suitable electrodes. Microelectrodes would solve problems related to low ionic strength, stirring, and minimised volume. Recent developments in micro machining and chip manufacture have enabled the possibility to make microelectrodes, and arrays of microelectrodes, sufficiently robust for in-site detection. We are experienced in the electro analytical detection of metal and sulphide species, and we have the electrochemical instrumentation to back this up. We are looking for a person to help us make, and test, microelectrodes and/or micro array electrodes. We hope to be able to test different materials such as gold, silver and iridium. It minimise the use of mercury we may have to use specific electrodes for specific aims, such as silver for lead detection. We are looking for someone experienced in the use, and making, of microelectrodes and arrays of microelectrodes. Contact: Prof. Stan van den Berg Marine Electrochemistry Group, Oceanography Laboratories, University of Liverpool;vandenberg@liv.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultra thin glass membranes for advanced, adjustable and affordable quadruple glazing windows for zero-energy buildings' (MEM4WIN), addressing dissemination and exploitation.

assistant: **Impact**

Windows are critical elements to control the energy performance of buildings especially for zero-energy buildings. It is of paramount importance to develop windows which show reduced U-value, weight and costs and certain features to control and harvest energy. Such a window will have a high impact in the window industry and will reduce green house gas emissions as long as the window is affordable, can be used in renovation and in every climate zone. Therefore MEM4WIN is aiming at the following goals (1) weight reduction (2) energy control and harvesting (3) replacement of cost intensive processes and materials.(1) We will introduce a  novel IG-Unit for quadruple glazing containing ultra thin glass membranes dedicated as frameless openable windows for direct application in facades. Due to this approach U-values of 0.3 W/m²K can be achieved reducing weight by more than 50% and costs by 20%.(2) We will implement printed organic photovoltaics (OPVs) and solar thermal collectors for energy harvesting and micro mirrors for energy control and advances day lighting.(3) Fabrication costs will further be reduced by replacing conventional and cost intensive materials used for contacts like ITO and silver by graphene. We will introduce production methods like roll-to-plate and ink-jet printing to fabricate contacts for OPVs.At the end of the project the different components like micro mirrors, OPVs, organic light emitting diodes (OLEDs) and solar thermal collector will be integrated into a demonstrator showing the suitability of the used equipment, processes and new materials developed within MEM4WIN.Each aspect of MEM4WIN - (1) weight reduction, (2) energy control and harvesting, (3) replacement of cost intensive processes and materials - is represented by experts in this field re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Functional characterisation of rhomboid'.

assistant: **Concept**

Research objectives and content The Drosophila rhomboid gene (rho) is involved in the activation of the EGF Receptor signalling pathway, leading to cell fate determination and differentiation at many developmental stages. Despite intensive genetic studies, the structure, function and partners of Rhomboid remain elusive. The aim of this project is to further our knowledge of the mechanisms by which Rhomboid leads to the activation of the EGF receptor. There are indications that Rhomboid may define a new family of proteins conserved through evolution, giving this project a broader impact. The novelty of my approach consists in its multidisciplinary nature, using biochemistry and cell biology to study the structure and intracellular localisation of Rhomboid, and molecular biology and genetics to perform two convergent screens that should enable the identification of genes and gene products that interact with Rhomboid and will help elucidate its function. training content (objective, benefit and expected impact) My scientific career will benefit greatly from the multidisciplinary approach to a problem that lies at the intersection of signal transduction,cell fate determination, and control of cell proliferation. This project also involves the use of multiple techniques that will be extremely useful in my future career. In particular, I will develop skills in Drosophila cell culture, and the use of the yeast two-hybrid system. I expect that the training gained during this project will greatly benefit my incorporation to the research system in Spain and also have a positive impact in other-researchers through future collaborations. Links with industry / industrial relevance (22) This project will have no direct industrial relevance,although it will further our understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Human Chaperone Mechanisms Counteracting Protein Misfolding and Aggregation in the Cell' (CHARM) targeting Horizon Europe.

assistant: **Abstract**

MolecuMolecular chaperones are vital for maintaining proteostasis by protecting our cells from the deleterious effects of protein misfolding and aggregation. The diverse ~50-chaperone J-domain protein (JDP, Hsp40) family acts as cells first line of defense, binding and remodeling non-natively folded proteins and facilitating their transfer to downstream chaperones. Recent discoveries from our lab have shown that JDP function is far more complex than previously described - identifying both a novel mode of regulation by which DNAJB1 coordinates amyloid disaggregation, and a new mechanism by which class A JDPs recognize destabilized proteins. Based on these findings and the sheer diversity of human JDPs, we propose that these chaperones employ many additional, yet-to-be-discovered mechanisms to carry out their vital cellular roles. Obtaining a structural and functional understanding of these chaperones is further crucial, as mutations in JDPs have been linked to many pathologies, including myopathies, neurodegenerative diseases, and metabolic disorders. Here we aim to uncover these novel JDP functional mechanisms, determine their role in addressing diverse proteomic challenges, and characterize how their malfunction leads to disease. Study of JDPs has proven challenging due to the dynamic nature of these chaperones, their transient interactions with clients, and the instability of misfolded proteins. The advanced methyl-TROSY NMR techniques used in my lab are, however, ideally suited for such large and dynamic systems.  Furthermore, we have developed new NMR and biophysical assays allowing the monitoring of chaperone interactions with misfolded and aggregation-prone substrates in real time.Using these approaches, this project will unveil the structures and functional mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Geotraceagri' (GEOTRACEAGRI) under Fifth Framework.

assistant: **Objectives**

The main innovation of the GeoTraceAgri project comes from the use of the geomatic technology in all the steps of the agribusiness channel, from the field to the distribution to consumers. Present georeferencing data used in trace ability process will be a substantial added value in comparison with the commonly used methods. The certificate of origin now measurable (terroir, region, country) will become an objective data and will replace present indications of origin mainly based on declarations.Objectives:With the globalisation of exchanges, the citizen has become an experienced consumer, very particular about the origin of the food he consumes and on the protection of the environment. He requests a trace ability going from the producer to the distribution of agribusiness products. The consortium GeoTraceAgri considers that a certification of the geographical origin is a key element in the trace ability process. Starting from the example of the geomatic technology applied in precision farming, GeotraceAgri proposes to conceive relevant geographical information indicators, tools and methods that are able to provide acceptable answers both to the citizens concerned about food security and environmental protection.Work description:The purpose of the GEOTRACEAGRI project is to define a methodology for the sampling, acquisition, utilization and processing of georeferenced data that will be used to generate agro-environmental indicators at various geographical scales. The first task consists in the definition of the indicators and in the determination of the indicator classes that are relevant to geographical trace ability in agriculture. The various geographical scales considered are: the plot, the field, the catchments and the region for which the origin of the product is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An Integrated View on Coupled Aerosol-Cloud Interactions' under Horizon 2020.

assistant: **Concept**

Despite their abundance in the Earths atmosphere, cloud formation and evolution are still poorly understood. This is particularly true for the interactions clouds have with atmospheric aerosol particles and their precursor vapors, which hampers our knowledge on the role that clouds and precipitation play in the climate system and in governing air quality. I argue that a major fraction of these uncertainties stem from inconsistencies and discontinuities in treating 1) the molecular phase transitions driving the dynamic cloud formation processes; 2) the interplay between atmospheric chemical composition and atmospheric dynamics; 3) the complex role that clouds play as both sources and sinks of particulate matter, but also as subjects to changes driven by aerosol particles. INTEGRATE will address these inconsistencies, and acquire a comprehensive picture of the phase transitions leading to cloud formation over the relevant scales. INTEGRATE will fill the key knowledge gaps through work in 1) the process scale, developing, applying and evaluating descriptions of molecular phase transitions within clouds; 2) the cloud scale, integrating the relevant chemical, microphysical and dynamic phenomena in a 3-dimensional cloud simulation framework; 3) the regional and global scales, studying interactions between aerosol loadings and clouds in past, present and future climates using chemical transport and earth system modeling. Systematic approaches for bridging the gap between the various time and spatial scales will also be developed within INTEGRATE. If successful, INTEGRATE will open new avenues for 1) fundamental understanding of the physics and chemistry of atmospheric phase transitions; 2) improved climate projections and ultimately better policies for reaching the targets of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation of migration models to be used under Directive 90/128/EEC', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

OBJECTIVES Describe the objectives of the project and the advances that it represents in relation to the current state of the art and where appropriate the links to industry and Community policy measures that it concerns. Among others this section should adress the following points: The objectives. An explanation of how the proposal objectives comply with the objectives of the work programme and its priorities. A brief summary of the issues involved and the current state of the art (please mention the most up-to-date scientific references relevant to the proposal objectives) For demonstration project.i justify the need to undertake a demonstration phase and explain why the level of knowledge reached so far makes demonstration viable.  1. OBJECTIVES The overall largcl Or this projccl is to dcmonstrate the currcnt capabilities of migration models and to validate the application records. The intermediate objectives are: 1.1 Collcct all available diffusion and migration data in order to complete and combine the existing data banks and verify their reliability. 1.2 Dcmonstrate the applicability of the current models for polyolefins. 1.3 Verify thc applicability of the migration equations derived from Fick's laws in non-polyolefin systems with Pseudo-Fickian or Non-Fickian behaviour, considering worst case situations. Polymers with high glass temperatures alld polymers with a high concentration of plasticizers fall into this category. 1.4 Extend the model to include interaclions between polymer and food, especially at high temperatures. which produce higher migration rates. 1.5 Considcr the partition coefficient Kp/F-values, in order to allow more realistic estimations avoiding exaggerated worst case migration values. 1.6 Incorporate thc mass transfer resistance in solid food
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cerebellar circuits for locomotor learning in space and time' (LOCOLEARN).

assistant: **Concept**

Every movement we make requires us to coordinate our actions precisely in space and time. This proposal aims to understand how that remarkable coordination is achieved by neural circuits controlling movement. The cerebellum plays a critical role in keeping movements calibrated and coordinated, and it is thought to do this in part through a motor learning process in which predictable perturbations of movement are gradually compensated. Cerebellum-dependent forms of motor learning have been identified for a variety of behaviors, including locomotion, and locomotor learning is used as a rehabilitative therapy in human patients. We recently established locomotor learning in mice, using a custom-built, transparent split-belt treadmill that controls the speeds of the two sides of the body independently and allows for high-resolution behavioral readouts. Here, we will combine quantitative analysis of locomotor behavior with genetic circuit dissection to answer two fundamental questions: How are cerebellar outputs read out by downstream circuits, to calibrate spatial and temporal components of movement? and How are instructive signals for spatial and temporal learning encoded by cerebellar inputs? Specifically, we will: 1) Use circuit tracing combined with manipulation of specific cerebellar outputs to identify downstream pathways for spatial and temporal locomotor learning, 2) Investigate the role of error signals for cerebellar learning via optogenetic perturbation of climbing fiber inputs to the cerebellum, and 3) Image complex spike activity from populations of Purkinje cells during locomotion and learning, to ask how spatial and temporal error signals are encoded within the cerebellum. These studies will allow us to bridge levels of analysis to understand how cerebellar le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stereoretentive-Enantioconvergent Catalysis: A New Concept in Asymmetric Synthesis' (SEC) targeting Horizon 2020.

assistant: **Abstract**

This project will experimentally establish a new concept in asymmetric synthesis: stereoretentive-enantioconvergent catalysis. This will represent a completely new method for accessing enantiopure materials starting from racemic substrates and will therefore impact all areas of synthetic chemistry. The ability to synthesise chiral molecules in enantiopure form is vitally important, most recognisably for the pharmaceutical industry. This is because the molecules of life are chiral (e.g., D-sugars and L-amino acids) and enantiomers often interact very differently with living organisms. Classically, asymmetric synthesis utilising racemic substrates is limited to achieving a maximum yield of 50% (e.g., kinetic resolutions). Enantioconvergent catalysis avoids this limitation with both enantiomers of the starting material being converted into a single enantioenriched product, thanks to complex stereoablative or stereomutative de-racemisation processes. This project will establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no de-racemisation required. This new concept will prove highly valuable for the synthesis of small enantiopure building blocks, which will be of high value in many areas of synthesis, and also for more complex late-stage transformations in complex molecule synthesis. Several approaches will be pursued to demonstrate proof-of-principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.


**Keywords:** Enantioconvergent Catalysis, Asymmetric Synthesis, Domino Reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CrowdLaw: Towards a More Inclusive Lawmaking Through Technology' in the context of a Horizon 2020 call.

assistant: **Objectives**

With rates of trust in government at all-time lows, the legitimacy of traditional representative models of lawmaking, typically dominated by political party agendas and conducted by professional staff and politicians working behind closed doors, is called into question. But technology offers the promise of opening how parliaments and local legislatures work, creating new challenges and dangers for individual rights and democracy, but also generating unprecedented opportunities for improving the legitimacy and, more generally, the quality of law and decision-making in our political systems. CrowdLaw refers to the use of technology to engage the public in all stages of the lawmaking process, from problem identification to solution identification, proposal drafting, ratification, implementation and assessment. This research project deals with CrowdLaw in order to understand (theoretically and empirically) its impact on legislative institutions, the public and political culture. By exploiting technology to engage a broader and more diverse constituency in the lawmaking process, CrowdLaw has the potential to enhance the quality of lawmaking practices and to transform fundamentally the source of authority undergirding the legislative process. In this sense, three broad hypotheses will guide my work to measure the impact of digital democracy on individual participation, information quality and legislative outcomes. To do so, I am planning to: 1) Develop a taxonomy to organize and analyse CrowdLaw practices; 2) Conduct mixed-methods research to evaluate different CrowdLaw modalities and their legal frameworks and 3) Transform two local legislatures (Barcelona and Madrid) into CrowdLaw living labs to be able to conduct experiments that allow me to test how CrowdLaw initiatives i