RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dual-channel CMOS for (sub)-22 nm high performance logic', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose to develop for the first time a dual-channel CMOS technology comprising high channel mobility (high-µ) Ge pMOS and III-V compound semiconductor nMOS transistors co-integrated on the same complex engineered substrate on Si. This offers a high performance booster as an option for the 22 nm technology creating competitive advantage for the European nanoelectronics industry. In addition, high-µ dual channel CMOS could be the main new introduction in sub-22 nm nodes in agreement with the strategic planning of the ENIAC technology platform. The project will develop the full set of FEOL modules from the starting local GeOI substrate to the dual-channel engineered substrate, the high-k/metal gate stacks and the S/D junctions with low resistivity contacts. Our aim is to use surface inversion channels and a self-aligned process with implanted S/D contacts for both III-V and Ge MOSFETs to ensure compatibility with the scaling and operation rules of CMOS. Device modelling and circuit design will assist in selecting the most suitable device architecture. The technology will be validated by the successful co-integration of short channel functional transistors using a 65 nm/200 mm pilot semiconductor processing line. This will allow characterization in terms of mobility at short gate lengths and identification of possible showstoppers associated with the behavior of high-µ channels at nanoscale dimensions. In addition, using toolsets, process flows and know how similar to Si, we aim at demonstrating that the high-µ dual channel technology is scalable and manufacturable without the need for introducing costly and disruptive technologies, thus ensuring the CMOS evolution for next generations. Mobilizing major technology development laboratories in Europe along with leading se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The biological clock in the brain : circadian genes and the sense of time (BRAINTIME)' (BRAINTIME).

assistant: **Innovation**

Human adaptation to modern 24-h society is constrained by dominant endogenous periodicities in physiology and behaviour. These rhythms, including the sleep-wake cycle, are generated in the brain's suprachiasmatic nuclei (SCN). Their understanding has major biomedical impact in the combat of sleep disorders, control of fatigue and risk, adjustment to shift work, timing of drug therapies. Big strides are being made in unravelling the physiological and molecular basis of circadian rhythms. Building on these advances we combine molecular, brain and behaviour studies to elucidate the control of sleep-wakefulness in mouse models and humans. Human studies focus on screening for phase variations in sleep-wake rhythms and their molecular characterization. Mouse strains with genetically modified circadian genes are exploited to characterize the mechanism underlying SCN oscillations and establish time-specific neuroanatomical mapping of circadian gene expression throughout the brain. Complementary expertise allows the assembly of a coherent picture of generation and synchronization of neuronal clocks involved in adaptation to a rotating planet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Computational Horizons In Cancer (CHIC): Developing Meta- and Hyper-Multiscale Models and Repositories for In Silico Oncology'.

assistant: **Objectives**

Developing robust, reproducible, interoperable and collaborative hyper-models of diseases and normal physiology is a sine qua non necessity if rational, coherent and comprehensive exploitation of the invaluable information hidden within human multiscale biological data is envisaged. Responding to this imperative in the context of both the broad Virtual Physiological Human (VPH) initiative and the paradigmatic  cancer domain,  CHIC proposes the development of a suite of tools, services and secure infrastructure that will support accessibility and reusability of VPH mathematical and computational hypermodels. These will include a hypermodelling infrastructure consisting primarily of a hypermodelling editor and a hypermodelling execution environment, an infrastructure for semantic metadata management, a hypermodel repository, a hypermodel-driven clinical data repository, a distributed metadata repository and an in silico trial repository for the storage of executed simulation scenarios. Multiscale models and data will be semantically annotated using the ontological and annotating tools to be developed. An image processing and visualization toolkit, and cloud and virtualization services will also be developed. The CHIC tools, services, infrastructure and repositories will provide the community with a collaborative interface for exchanging knowledge and sharing work in an effective and standardized way.  A number of open source features and tools will enhance usability and accessibility. In order to ensure clinical relevance and foster clinical acceptance of hypermodelling in the future, the whole endeavour will be driven by the clinical partners of the consortium. Cancer hypermodels to be collaboratively developed by the consortium cancer modellers will provide the framewor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced material for the regeneration of oral mucosa injuries' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of NEOFIBRIN is to undertake a technical, industrialization and market feasibility study on an innovative regenerative medicine treatment for masticatory oral mucosa injuries based on a new advanced material, HR018-Neofibrin. The use of this material to develop a tridimensional natural scaffold for restoring masticatory oral mucosa functional activity is expected to significantly increase treatment efficiency over currently marketed products and to provide an alternative to allogenic and autologous grafts to treat localized mucosal damage.The application of Tissue Engineering techniques in clinical dentistry has several well-known problems, key among them the generation of a supportive biomaterial with regenerative capacity without the loss of consistency. Our novel biomaterial HR018-Neofibrin was developed combining natural materials and an exclusive design to promote the progressive formation and maturation of new epithelium while maintaining structural properties. Fibrin, one of the proteins involved in wound healing, provides a temporary extracellular matrix that facilitates cell migration, invasion and proliferation. Agarose, a polysaccharide from seaweed, gives the mechanical properties that enable surgical suturing and open healing.Histocell, a SME specialized in human regenerative medicine, has obtained licensing rights to the production of fibrin-agarose based artificial tissues and scaffolds for regeneration of tissues and oral mucosa. Successful completion of Phase 1 of NEOFIBRIN will yield a robust business plan for a much larger project that will seek funding under Phase 2 of the SEM Instrument, when the company will adapt a new facility for advanced manufacturing of innovative medical devices for the production of the new biomaterial HR0
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REstorative GENder-specific ExpeRiences in urbAn naTural Environments' in the context of a Horizon Europe call.

assistant: **Objectives**

REGENERATE explores gender differences in how urban natural environments (UNE, comprising parks, seaside, and other green and blue spaces in cities) can support psychological restoration (i.e. recovery of depleted cognitive and psychophysiological resources, including recovery from psychological stress). It addresses challenges of urban sustainability, gender inequality, and poor mental health  all key for Europe and Horizon. The nature-health research field suggests that nature contact is restorative and promotes long-term health benefits. However, to date nature-health theories and evidence tend to lack a gender focus. This is despite women are up to seven times more likely than men to report depression. Regenerate explores how restorative benefits of UNE can be affected by gender (e.g. socio-cultural norms, attitudes, and behaviours), due to gender roles and relations (e.g. childcare responsibilities), gender stereotypes (i.e. what is socio-culturally appropriate for women) and sex-related biological attributes (i.e. needs to use restroom more often than men)  thus addressing a key theoretical and empirical blind spot. Specific objectives include i. reviewing evidence and identify factors affecting womens nature-health restorative pathways in UNE, ii. exploring gender-specific experiences in UNE and related long-term restorative benefits, and iii. integrate findings into policy. The methodology includes a review of the evidence and analyses of secondary data on nature-health from four European countries representing diverse European regions. Results then inform real-world policy. REGENERATE contributes to policies for healthy, gender inclusive, and sustainable cities (SDG3 Good Health & Wellbeing, SDG5 Gender Equality, SDG11 Sustainable Cities and Communities). It co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COmpton Scatter based Imaging for Nuclear Emissions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The main goal of my proposal is to exploit Compton scattering in PET imaging, a nuclear imaging technique well-established in clinical routine, mainly in oncology as a tool for tumor diagnosis and monitoring, but also through preclinical PET as an essential tool for pharmacology and drug development. By considering signal events undergoing Compton scattering, I expect to increase the sensitivity of PET systems, and so improve the attainable image quality. Sensitivity in PET systems is a key parameter to be optimized, as it could allow for dose exposure and/or scan time reduction, in addition to being critical in low-count regime scenarios, for pediatric patients, and in research applications involving small-animal imaging. Aside from increasing the sensitivity, the purposeful detection of Compton scattering in PET imaging opens the door for the use of this modality for new applications (e.g. immunoPET, theranostics...). However, incorrect/simplified modeling of these events can degrade PET image quality. My proposal relies on developing algorithms and models based on solid mathematical and physical foundations, able to include events involving Compton scattering into dedicated reconstruction frameworks. To this end, I intend to use the knowledge I have acquired during my PhD developing similar models and algorithms for imaging with Compton cameras. Specifically, I intend to address three questions: first, the inclusion of inter-crystal scatter events with particular focus on small-animal PET imaging; second, the modeling of object scattered events and their use in low-count regime scenarios; and third, the treatment of coincidence events that involve an additional emission of photons, either correlated or uncorrelated to the positron emission. The evaluation of the prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Quantitative analysis of Nodal/Lefty-mediated pattern formation'.

assistant: **Concept**

How an initially homogenous population of cells self-organizes to form patterned embryos and tissues is a long-standing mystery in the field of developmental biology. Understanding such self-organizing processes is of central importance for regenerative medicine and would inform approaches to transform embryonic stem cells into complex multicellular structures for human tissue replacement. The influential reaction-diffusion model postulates that patterns emerge during development under the influence of poorly diffusive activators and highly diffusive inhibitors, and we have recently found biophysical evidence supporting the differential diffusivity of the activator Nodal and its inhibitor Lefty in zebrafish embryos. While we have begun to define the Nodal/Lefty activator-inhibitor pair as a reaction-diffusion system that can transform a uniform field of cells into an embryo, three important questions remain: First, how is the differential diffusivity of activators and inhibitors achieved in living embryos? The molecular weights of activator and inhibitor proteins are too similar to explain the difference in diffusivities. Second, how do reaction-diffusion systems adapt to tissue size? Embryos can vary considerably in size, but the proportions of their body plans are remarkably constant. How reaction-diffusion systems mediate this scale-invariant patterning in vivo is unknown. Third, how do reaction-diffusion systems self-organize? Embryos are often born with maternally provided prepatterns, and it is unknown whether reaction-diffusion systems also form relevant patterns in the absence of such prepatterns. We will address these questions in zebrafish and mouse embryonic stem cells by combining innovative quantitative experimentation and mathematical modeling. This high-r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimising a Deployable High Efficacy Multi-Stage Vaccine for Plasmodium falciparum Malaria: 2nd Generation Malaria Vaccine Consortium' under Horizon Europe.

assistant: **Concept**

The 2nd Generation Malaria Vaccine Consortium (MVC-2G) will build on the programmatic use of the first-generation Plasmodium falciparum vaccine, R21 with Matrix-M™, and accelerate the clinical development of the leading second-generation multi-stage P. falciparum malaria vaccine comprising R21 and two novel blood-stage components, RH5.1 and R78C, all formulated in Matrix-M™. It will achieve this through a multi-disciplinary workplan, underpinned by international cooperation, that will accelerate the future achievement of the United Nations’ Sustainable Development Goal 3 (SDG3) in sub-Saharan African countries. Its specific objectives are to: 1. Demonstrate safety and superior efficacy against clinical malaria (over R21/MM alone) of the leading second-generation multi-stage vaccine candidate R21+RH5.1+R78C/MM in a Phase 2b trial in 5-17 month old African infants, in a seasonal setting; 2. In parallel, undertake Phase 1b assessment of the second-generation multi-stage vaccine in African infants to define a 3 or 4 dose delivery schedule that is better aligned with EPI and end-user community expectations, aiming for lower cost of goods and to facilitate improved future uptake of a second-generation product; 3. Demonstrate safety and superior efficacy of the multi-stage vaccine (over R21/MM alone) delivered in an optimised age-based schedule in a multi-site Phase 2b trial in African infants in seasonal and perennial settings; 4. Generate evidence to support use of the multi-stage vaccine in future malaria elimination campaigns by assessment of i) efficacy in adults by CHMI, and ii) safety and immunogenicity in older children; 5. Support the next-generation of early-career African scientists, across all partners in the Consortium, by growing a South-South network to facilita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'NOORDUNG'S MOBILITY SOLUTIONS-A Tool to Solve Scientific Travel Problems ''.

assistant: **Concept**

The Centre for Mobility and European Educational and Training Programmes (CMEPIUS), designated by the Ministry of Education, Science and Sport is an organization responsible for Socrates, Leonardo da Vinci programmes as well as other initiatives and bilateral agreements, covering mobility. Its daily tasks are personalized assistance and technical support to individual mobility and organizations submitting project proposals. As far as mobility is concerned the centre acts as a point of entry for foreign individuals looking for practical information and guidance concerning studying or working in Slovenia. The Centre's task is also the linking with relevant ministries, social partners, chambers, regional development agencies in order to provide for up-to-date information for the incomings as well as Slovene institutions, dealing with mobility. The Centre works on a daily exchange of information or problem solving with other National agencies abroad as well as with the European Commission. The centre actively participates in many working groups for thematic monitoring, quality issues of mobility and the simplification processes. Due to Centre's central role, designated by the Ministry, the project represents a unique opportunity to bring together different organizations and institutions, which will form a national network in the field of research. Moreover the Centre is in the position to cooperate with national and local authorities, responsible for the implementation of legal and administrative procedures, which represent one of the main issues to be tackled in order to promote and facilitate research mobility to Slovenia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Implementing Legislation on Invasive Alien Species: Investigating socio-cultural attitudes in the management of Invasive Alien Species in EU member countries' to be submitted under Horizon Europe.

assistant: **Abstract**

ILIAS investigates how socio-cultural, affective and scientific perceptions shape the implementation of EU laws for the prevention and management of invasive alien animal and plant species (IAS) in EU member countries. The European Parliament legislates policy responses to a list of 66 IAS of EU concern, but conceptual, socio-cultural and practical barriers prevent collaborative implementation. Key terms such as ‘biodiversity’ or ‘nature’ lack a shared definition; methods for the management and eradication of IAS are controversial; academic experts engage in fractious disagreements.  These issues, which complicate unified strategies to prevent and manage IAS across EU member countries, point to implicit and unacknowledged socio-cultural factors that shape human relationships with the environment including religious beliefs, ideas about local identity and heritage and anxieties about environmental change. ILIAS  studies these socio-cultural attitudes and framings around species dispersal, their influence on the way scientific evidence and best-practice for IAS management among stakeholder groups are interpreted, and how this affects the implementation of EU laws using interdisciplinary methods and theoretical frameworks. ILIAS is based on the following research questions: How do personal attitudes, beliefs and value judgements among stakeholders shape the implementation in different member countries? How do socio-cultural framings influence the interpretation of scientific evidence? Do the different conceptualisations present barriers in collaborative action and compliance with EU laws and if so, how can a more unified approach be facilitated? The resulting insights will contribute to a better understanding of the barriers to implementing coordinated strategies across EU