RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mitochondrial membrane organization by protein scaffolds and lipid dynamics'.

assistant: **Concept**

Biological membranes are complex structures built up of a multiplicity of membrane lipids and proteins controlling essential cellular processes. This is exemplified by mitochondria, dynamic double-membrane bound organelles, with essential roles in diverse metabolic and cellular signalling pathways. The mitochondrial inner membrane is considered to be the protein richest cellular membrane, whose functional impairment is associated with aging, myopathies and diverse neurological disorders in human. Recent evidence from our group revealed essential roles of large, ring-like prohibitin complexes in the inner membrane for embryonic development in mice, cell proliferation, resistance against apoptosis, and the maintenance of mitochondrial cristae. Prohibitins comprise a conserved and ubiquitously expressed protein family and are suggested to serve as protein scaffolds in the inner membrane. Defining the network of genetic interactions in yeast, we could establish that prohibitin function depends on the supply of the non-bilayer phospholipids cardiolipin and phosphatidyl ethanolamine and on intramitochondrial lipid trafficking. These findings indicate that mitochondrial function and ultrastructure requires a defined spatial organization of the inner membrane, which is maintained by a defined lipid composition and prohibitins serving as protein scaffolds. Here, we propose a comprehensive analysis of the function of prohibitins and of novel components involved in mitochondrial lipid trafficking and phospholipid biosynthetic pathways. These studies will include genetic as well as biochemical and proteomic approaches and employ both yeast and murine models to integrate the molecular understanding of functionally conserved processes into the physiological context. As components of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy' (2014-2020) under Horizon 2020.

assistant: **Objectives**

As a Marie Skłodowska-Curie Fellow in “qBioNano: Quantifying bio-nano interactions of nanoparticles through microfluidic live cell Raman spectroscopy”, I will combine three emerging fields—layer-by-layer (LbL) assembly of nanoparticles (NPs), microfluidics, and live cell Raman spectroscopy (RS)—to enable 3D imaging and quantification of how NPs and cells interact under physiological conditions. This will allow, for the first time, non-invasive, non-destructive, label-free, spatiotemporally resolved study of a range of biomolecules (e.g., lipids and proteins) and biostructures (e.g., nuclei and mitochondria) at the same time as LbL assembled NPs to answer long-standing questions on particle-induced changes in cellular states and processes. The NPs will be produced through LbL assembly of alkyne-containing polymers (having Raman spectra clearly visible in biological environments), and—using microfluidic devices (where cells can be introduced and maintained in physiologically relevant environments)—I will study how these NPs affect both healthy and diseased cells and tissues (e.g., at cell-cell interfaces and using spheroids). This project will provide: (i) the first detailed view into the biology underlying cellular responses to LbL assembled NPs under physiological conditions, and (ii) a new platform offering insight into key cellular processes and responses governing how cells and tissues interact with, and respond to, engineered NPs. By combining my expertise in developing NPs, microfluidic systems and investigating bio-nano interactions, with the supervision of Prof. Molly Stevens at Imperial College London (ICL), who runs a world-class interdisciplinary biomaterials group with extensive experience in RS, materials science, and cell and tissue biology, this project is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Emissions Characterisation and Inventories'.

assistant: **Concept**

Specific Objectives:To contribute to the development of new/amended Directives for motorcycles (WMTC) and non-road engines (NRTC). To anticipate future needs by performing research related to fuel types, fuel consumption and emissions in fields of future importance. To provide technical expertise for the implementation of Community Strategy on dioxins in Candidate Countries and for the planned 2004 review of the Large Combustion Plants Directive. To set up and use a facility for the measurement of pollutants from co- combustion of waste in household furnaces, fireplaces and heating systems. The facility will then be used for the characterisation of non-regulated industrial emissions by means of advanced techniques with the view of introducing new standards/limit values. To improve the compilation of emission inventories from mobile and stationary sources, with focus on the contribution of small combustion sources to the dioxin inventories in the EU and CC.To contribute to the improvement of the evaluation of the methodologies and the process of preparation of emission inventories in Member States and Candidate Countries. To act as training site for Member States, Candidate Countries, Balkan and Mediterranean States. To collect particulate matter data at an urban to regional scale through ad-hoc campaigns and measurement networks in order to determine the impact of sources on PM over Europe. The first measurement campaigns will be organised under controlled test conditions and in large metropolitan and background areas by means of mobile laboratories to chemically and physically characterise emissions from stationary and mobile sources. Anticipated milestones and schedule No.milestone Date/Month 1Completion of motorcycle testing for WMTC 6 1Motorcycle testing and 2stroke
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'U-space for UAM' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Aiming to bridge the gap between development and deployment, this VLD project will tackle issues of operational concepts, regulation, and standards, while building confidence in a safe and orderly integration of UAM in every days air traffic. It will do this with a consortium of forward-looking cities and ANSPs, national regulators and EASA, a well experienced UTM provider, as well as eVTOL manufacturers, research centers, and technology providers. A series of well defined, iterative and multi-national demonstrations, both with drones and UAM vehicles will be conducted. They will cover different use cases, including mixed operations, to allow the project to derive critical enablers for a wide set of UAM service applications that can be applied all over Europe. Uspace4UAM will build on the CORUS project results and on operational and business experience already gathered in operational drone service implementations in Europe. it will study safety cases and their impact on system requirements, and look at how regulation and standardisation can be set up to support innovators to build a sustainable business case while operating safely in a multi-modal transport network. This project is set to deliver results that are of real interest to “early movers”, enabling them to bring a real market impact in the next few years. In order to prove that this will be achieved, and that indeed the project has laid a bridge between development and deployment, the project is set to deliver a number of commercial contracts for the provision of fully automated drone services, and present solutions to identified gaps towards fully autonomous Urban Air Taxi services.


**Keywords:** U-space, Urban Air Mobility, Flying taxis, Air Taxi, Drones, Autonomy, Demonstrations, Smart Cities, UAM ConOps,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Technical and Social Innovations in the Caucasus: between the Eurasian Steppe and the Earliest Cities in the 4th and 3rd millennia BC' (ARCHCAUCASUS).

assistant: **Concept**

This project leads to one of the most dynamic regions in prehistory: the Caucasus of the 4th and early 3rd mill. BC. During this vibrant time, basic innovations emerged, which were crucial until the 19th century: wheel and wagon, copper alloys, the potter’s wheel, new breeds of woolly sheep, domestication of the horse, and others. At the same time, massive migrations from the East European steppe during the early 3rd mill. BC changed the European gene pool.The project challenges the still predominant narrative that all technical achievements stemmed from urban centres in Mesopotamia. New studies have created space for alternative hypotheses: possibly it was not the development of new techniques, but instead their adaptation from different ‘peripheries’ and their re-combination and re-configuration that formed the basis for the success of these ‘civilisations’.The Caucasus, linking Mesopotamia to the Eurasia and Europe, is for the first time in the focus of a study on innovation transfer. The study will make a major contribution by investigation of four axial innovations: wheel and wagon, metal alloys, silver metallurgy and woolly sheep. 40 wheels will be analysed by computer tomography and strontium isotopes. Some 300 copper alloys artefacts and 200 silver objects will be examined using mass spectrometry with laser ablation. 400 aDNA genom-wide analyses of humans from burials in the North Caucasus will offer the unique chance of elucidating the role of migrations for the spread of innovations. The pottery in the region, often linked to Mesopotamia, will be studied under technical aspects and is a complementary path to shed light on migration and the transfer of knowledge. Excavations in settlements will allow building up a chronology using 400 AMS 14C analyses. The proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '‘Stay home’: emergency, (im)mobility, and the liberal subject' in the context of a Horizon 2020 call.

assistant: **Objectives**

The MOBILISE project aims to critically investigate the COVID-19 emergency through the prism of (im)mobility and citizenship by scrutinising EU citizens’ actions, reactions and inaction. By scrutinising acts of compliance, resistance and contentious politics in Europe, this project will critically investigate not so much emerging disciplining and policing practices but who the European liberal-subject-during-emergency is. By scrutinising the level of (non-)conformity as well as the reasons for it, it will be possible to map not only how common EU citizens have experienced, and are still experiencing, the crisis, but most importantly, what kinds of subjects/citizens have emerged out of it. Who is the ‘citizen of emergency’? Or perhaps even better: what defines a good citizen during an emergency? Is it freedom? Is it democratic participation? Or is it responsibility? What does it mean to act as a responsible citizen? To what extent are the protests against and during the lockdown irresponsible acts? Which modalities of action make a citizen an irresponsible citizen? Is it the very act of contravening restrictions? Is it the non-compliance with health norms? In other words, should recent protests be investigated through the prism of citizenship and freedom, as traditionally done? Or should protests-during-emergencies be investigated through a different prism? These are some of the key questions that the MOBILISE project will investigate.        By investigating citizen protests during and against governmental lockdowns, in Italy and in France, the MOBILISE project will uncover not only the modalities through which EU citizens are making their voices heard, but also the extent to which ""a new push for European democracy”  has emerged despite the many mobility restrictions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating Methane for Climate Action' (IM4CA).

assistant: **Concept**

The IM4CA proposal unites leading European methane experts in a concerted effort to establish the scientific fundament needed to bring the climate forcing of methane under control. Specific objectives are to: 1) Strengthen methane mitigation policy world-wide with actionable information on local methane emissions and key driving processes, 2) Provide the EU with the measurement and modeling capacity needed to monitor its methane emissions and assess its progress towards the 30% emission reduction target of the European methane strategy and the global methane pledge, 3) Explore and understand climate feedbacks on natural methane sources and sinks, and 4) Improve the accuracy of climate scenarios by resolving the controversy about the causes for the recent growth rate variations in global methane. To achieve these objectives we address a selection of key uncertainties that have thus far limited the progress towards these goals by: i) building up critical new infrastructure for monitoring methane emissions in Europe and Tropical Africa, ii) developing methodology for efficient use of existing and upcoming satellites for measuring methane and the land surface properties needed for characterizing and attributing its emissions, and iii) translating the knowledge obtained into reliable projections of future methane and efficient emission mitigation scenarios. In doing so, the IM4CA project will enable a breakthrough in meeting the work program challenge of enhancing the quantification and understanding of natural and anthropogenic methane emissions and sinks. It will provide enhanced European assessment capacity of short- and long-term changes in methane sources and sinks integrating information from multi platforms and novel observations and transfer that capacity into action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Uncovering the mechanism and physiological relevance of myosin-VI-dependent AMPA receptor trafficking in neurons.'.

assistant: **Innovation**

The proper trafficking of membranes and associated proteins in neurons is crucial for the function of the nervous system. Myosin-VI is an actin-based cytoskeletal motor that promotes membrane trafficking and is suggested to play crucial roles in neurons. Most notably, the myosin affects the intracellular trafficking of AMPA receptors, major neurotransmitter receptors composed of transmembrane protein subunits. In addition, data suggest a potential link between myosin-VI and neurodegenerative diseases such as Alzheimer’s. Here, we want to dissect the molecular mechanism by which myosin-VI acts in AMPA receptor trafficking in neurons. Furthermore, we aim to determine the relevance of myosin-VI-driven AMPA receptor trafficking events for structure, function and plasticity of a well-characterized neuronal circuit, and for behavioral output. To this end, we will focus on Purkinje neurons as a model system. These cerebellar neurons are crucial for the coordination and fine-tuning of movements and for certain forms of motor learning. We will make use of genetically altered mice in combination with approaches such as transfection and live cell microscopy of cultured Purkinje neurons, in vitro genetic rescue experiments, ultra-structural analyses via electron microscopy, electrophysiological methods and behavioral tests. We expect that our study will provide novel, general insights into the mechanism by which myosin-VI functions in membrane trafficking. In particular, the results should shed new light onto the molecular and cellular events that take place in Purkinje neurons and determine output from the cerebellum. Moreover, understanding the mechanism of function of neuronal myosin-VI might impact our view of the pathogenesis of neurodegenerative disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Characterization of the signalling and physiological roles of the class II PI3Ks' (2014-2020).

assistant: **Concept**

Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate intracellular second messengers in signal transduction and membrane trafficking pathways and are important drug targets. This proposal seeks to delineate the roles and mechanism of action of a group of PI3Ks which have remained enigmatic ever since their discovery over a decade ago.The PI3K family comprises eight members in three subclasses. Class I PI3Ks signal downstream of growth factor and G protein-coupled receptors, are amongst the most commonly mutated genes in cancer and are being exploited as drug targets. The class II and III PI3Ks have in part emerged as regulators of membrane trafficking pathways but their physiological roles remain poorly understood.We aim to identify the physiological roles of the class II PI3K-C2α and β and to characterize the impact of their kinase activity on signalling pathways. To analyse the roles of class II PI3K activity in vivo, the Host Laboratory has created constitutive global and conditional knock-in kinase-inactive mice (unpublished). In contrast to PI3K gene knockout models, these mouse lines allow us to specifically address kinase-dependent functions and hence are an ideal model to evaluate the potential of class II PI3Ks as drug targets.The class II PI3K-C2α (C2α) is involved in endo- and exocytosis as well as endocytic recycling, whereas PI3K-C2β (C2β) has been implicated in cell migration. However, their influence on cellular signalling is unknown. As an initial approach, the Host Laboratory performed a screen for proteins interacting with C2α or C2β (unpublished). We will explore hits from this screen using the kinase-inactive knock-in mice and cells derived thereof as discovery tools. The combination of my expertise in membrane traffic and phosphoinosit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Support to Tenth European Conference on Turbomachinery – Fluid Dynamics and Thermodynamics, Lappeenranta, Finland, 15-19 March 2013'.

assistant: **Concept**

The European Turbomachinery Conference is the only scientific event in the EU covering in depth all fluid dynamics and thermodynamics aspects of turbomachinery design and operation. Its objectives are to enhance excellence in this field, to address and improve the technological level and competitiveness of turbomachinery design products and their operation as part of propulsion systems and energy conversion processes. EUROTURBO 10 is the tenth in a series of bi-annual conferences started for the first time in Erlangen (Germany) in 1995. This conference will be of prime interest to researchers, design engineers, users of turbomachinery components and to students being trained in presentation and discussion of their first scientific results. The conference is intended to be a primary driver for technology transfer across Europe in this field through the presentatiion of the latest developments and best practices. It is also intended to enhance cross-fertilization between the aeronautical fields, found in the edge of turbomachinery technology today and all other fields using turbomachines. The conference is also seen as an integrating element between the Western and the Eastern European countries and asan additional mean to foster collaboration in turbomachinery research at a European level. Finally, this conference is seen as an ideal forum to relate and disseminate the results of research projects funded by the European Commission. Therefore, a support for thisconference of less than 11 % of the total budget is requested from the Commission.