RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Implementing cooperation on Future Internet and ICT Components between Europe and Latin America' (FIRST).

assistant: **Innovation**

FIRST is a Support Action that intends to foster International Cooperation in the areas of Future Internet and ICT Components and systems   between Europe and Latin America.The aim of the project is to extend the constituency of European Technology Platforms (ETPs) to Latin American strategic stakeholders from the different sectors included in the Future Internet field.The extension of the ETPs constituencies to be performed by FIRST will include, at least, the following activities:- - Identification of key stakeholders, that prove to be best suited to launch and run Technology Platforms in Latin America (Argentina, Brazil, Chile, Colombia and Mexico; preliminary studies in Costa Rica, Ecuador, Panama and Uruguay) including representatives from industrial (large companies and SMEs) and academic sectors.- - Analysis of potential areas of cooperation between Europe and Latin America at national (Argentina, Brazil, Chile, Colombia and Mexico, as well as preliminary studies in Costa Rica, Ecuador, Panama and Uruguay) and Regional levels. This analysis will use ETPs thematic areas as an organizational model, but will not limit cooperation to these areas. - Promotion and support to the creation of Technology Platforms in Latin America at a national level in Argentina, Brazil, Chile, Colombia and Mexico, including the production of both organizational documents (governance, structure, etc.) and technical documents (Vision, Strategic Research Agenda). - Creation of a Regional Strategy for EU-LatAm cooperation in the field of Future Internet by compiling the different national strategies developed at a national level in Argentina, Brazil, Chile, Colombia and Mexico, - Liaising Latin American Technology Platforms with European counterparts, as well as providing periodic informati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Low salted dry-cured meat products from frozen raw material' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

There is a general agreement about the importance of the foodstuffs on both, health and its sensitivity for illness (diseases). In the opinion of many experts, the most important chronic diseases, which damage to the society, are related to foodstuffs. For example, hypertension is strongly related to hyper sodium diets (diets with high content in salt). This has caused an increasing interest of the meat products producers in reducing the salt content. On the other hand, the current surplus of meat in the markets motivates a greater production of frozen meat processing with this frozen material implicates important technological differences which are still unknown in the case of the dry-cured meat products. The main purpose of this project is to study the influence of raw meat freezing on the industrial production of raw dry cured meat products and its effect over textural, physic-chemical and organoleptic characteristics of typical products such as, ham, cuppa, salami, chorizo and loin with low salt content. Schematically, the Sees involved in the project will deal with swine production, slaughtering and meat processing under supervised condition. The research centres will be involved in the experimental distich, sample collection and analysis, data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detection of exo-Planets via High-Accuracy Radial-velocity spectrographic measurements with Adaptive Optics enHancement' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The PHARAOH project aims the detection of exo-Planets via High-Accuracy Radial-velocity spectrographic measurements with Adaptive Optics enHancement. The chief objective of this proposal is therefore to assess the impact of adaptive-optics (AO) correction on the detectability of Earth-like planets with a high-resolution, high-stability spectrograph on the future European Extremely Large Telescope (E-ELT).Since the discovery of planet 51 Peg b by M. Mayor and D. Queloz, huge progress has been made in the detection and characterisation of extra-solar planets. The increasing instrumental precision (in particular in the Doppler radial velocity (RV) domain) has raised the detection efficiency and allowed the scientific community to discover in 2004 the first ‘Neptune-mass planet’. The goal with the next generation spectrographs is to be able to detect rocky planets on current telescopes and Earth-like planets with the E-ELT. For that end an outstanding RV precision of 1 cm/s is required to detect the wobble of harbouring stars caused by a revolving planet. Embedding AO in actual instruments can further increase their precision in RV and their efficiency.For this fellowship, 3 work-packages were identified with scientific and management objectives: 1) AO simulations of the E-ELT, 2) impact of AO on spectrographic resolution and 3) implementation of instrumentation-directed activities at the host institute. All packages will be developed in strong collaboration with the exo-planet and instrumentation communities, in particular those with which the host presently partners internationally: the ESPRESSO spectrograph for the Very Large Telescope and ESA’s PLATO mission.Through a pondered choice of training and transfer-of-knowledge actions together with an exciting scientific proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A multidisciplinary and circular approach towards the development of innovative, SAFE-by-design, (bio)degRadable multifunctional COATings' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Despite the relevance of polymers (e.g., coatings) in modern societies, the limited or absent (bio)degradability and recyclability associated with this class of materials pose serious environmental and health concerns. Addressing this challenge is thus a key priority being fully aligned with the EU Green Deal and the UN Sustainable Development Goals. To bridge this gap, a multidisciplinary team with researchers from seven countries, including one associate partner, has converged to achieve pioneer breakthroughs under the SAFERCOAT project.In this sense, SAFERCOAT aims to promote staff mobility and knowledge-sharing to develop eco-friendly polymeric coating formulations with enhanced biodegradability for aeronautical, maritime, and cultural applications. SAFERCOAT will focus on the (i) synthesis and modification of thermoplastic and thermosetting polymers to accelerate their degradation rate at the end-of-life; (ii) optimization, testing, and validation of coating formulations for targeted applications; (iii) assessment of the environmental and health impacts; and (iv) upcycling of end-of-life materials to produce add-value products. This scientific endeavor will rely on the synergy of specialized training and cross-sector and interdisciplinary mobility among the 6 universities and 4 industrial partners to promote knowledge growth, transfer, dissemination, and exploitation.The novelty of SAFERCOAT lies in incorporating high bio-sourced content and cutting-edge technologies to develop coatings with outstanding performance throughout the service life and high (bio)degradation after use, which will contribute to (i) decrease the coatings industry’s environmental footprint, (ii) revolutionalize the coatings end-of-life by transforming what is currently treated as a disposabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms and regulators coordinating replication integrity and DNA damage tolerance.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Accurate chromosomal DNA replication is of fundamental importance for cellular function, genome integrity and development. In response to replication perturbations, DNA damage response (DDR) and DNA damage tolerance (DDT) pathways become activated and are crucial for detection and tolerance of lesions, as well as for facilitating replication completion and supporting chromosome structural integrity. While important functions and key players of these regulatory processes have been outlined, much less is known about the choreography and mechanistic interplay between DDR and DDT during replication. Moreover, the principles by which they uniquely or commonly affect replication-associated chromosome integrity remain poorly understood.Here, we will use novel tools and a palette of ingenious genetic, molecular and proteomic based experimental strategies, to investigate the replication stress response triggered by diverse endogenous and exogenous cues, and to identify the underlying mechanisms. We will define the principles of local and temporal regulation of DDT in response to genotoxic stress, with a focus on the mechanisms of SUMO-regulated DNA metabolism processes. Additionally, we will investigate the topological DNA transitions triggered at intrinsically difficult to replicate genomic regions, stalled and terminal forks, with the aim of identifying key mechanisms and regulators of replication integrity at specific complex genomic regions or following specific types of replication stress. Finally, we will explore the relationship between DDT, replication fork architecture and sister chromatid cohesion in the context of DDR- and SUMO-orchestrated DNA transactions. We expect that these studies will reveal new aspects of how replication-associated DNA metabolism processes are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Solar Artificial Trees for Hydrogen on-Demand Production' to be submitted under Horizon Europe.

assistant: **Abstract**

The SOLAR-H2 project introduces a groundbreaking artificial tree (AT)-like technology for distributed, on-demand H2 production, designed for zero-carbon communities and off-grid applications. Unlike conventional electrolysers requiring high-purity water and grid electricity, this system has near-zero operational costs, leveraging solar energy and capture of reactants from the ambient. The aim is to develop a showcase prototype for the Solar Hub under development at the Univ Messina to present to stakeholders the potential of AT technologies.  The innovative approach integrates photo-electrocatalysis, where CO2 and H2O are converted into H2 and formic acid (FA) using sunlight. The latter acts as a hydrogen storage medium, enabling on-demand or continuous H2 production, even during the night, through catalytic decomposition. Additionally, the system ensures a closed-loop CO2 recirculation, with minimal losses compensated by external CO2 sources, making it a highly sustainable and carbon-efficient solution.  Building upon the ERC Synergy SCOPE project, SOLAR-H2 aims to advance the technology to TRL4. This will involve scaling up to a small-scale demonstrator, improving performance and gas-diffusion electrodes as well as the cell for stable continuous operation, and integrating the systems for capturing reagents and the storage/decomposition-on-demand of FA. The project assesses techno-economic and socio-environmental aspects, along with a market analysis to identify key barriers and opportunities. The exploration strategy is to build a first demonstrator for the Solar Hub to foster this important area of solar-to-chemical conversion and lay the foundation for a spin-off company, positioning formic acid as a breakthrough hydrogen vector in the clean energy transition. By br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultra-small Nanohybrides for Advanced Theranostics' (UNAT).

assistant: **Innovation**

Nowadays, research focusing on control and use of nanomaterials in different areas including life sciences has become a key driver of innovation. UNAT project aims at a systematic interdisciplinary study of metal-carbon nanohybrides (NHs) for advanced theranostic application. Indeed, development of NHs based on organic & inorganic moieties can synergistically or antagonistically influence functional properties of engineered nanotheranostic medicines. UNAT will develop innovative approaches for synthesis and multi-functional application of ultra-small (<10 nm) carbon-based NHs functionalized with various metal atoms for diagnostics and therapy of cancer. In particular, carbon cores of NHs will be chemically synthesized from biomasses and bio-wastes. The combination of pre-clinical in-vitro & in-vivo experiments will allow to evaluate theranostic potential of the NHs.UNAT will associate an industrial partner from Greece (Bioemtech), a research and innovation center from Ukraine (Science Park) and 2 academic research groups from France (UCBL) and Italy (CNR). The uptake efficiency and specific localization of the NHs in biological cells depending on their intentionally designed surface chemistry will be studied in details. Extremely rich physico-chemical properties of the NHs will allow their application as universal multi-modal (MRI, PET, X-ray, Fluorescence, Photoacoustic) in-vivo bio-imaging agents. The multimodal imaging strategy will allow us to correlate the images obtained with the use of various imaging facilities to increase general reliability of visualization of the NHs localization in tumours. Various exciting electro-magnetic sources used for medical purposes will be simultaneously used for therapy of cancer tissues containing the incorporated NHs. Strongly co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MachinE Learning Ledger Orchestration for Drug DiscoverY'.

assistant: **Innovation**

MELLODDY will demonstrate how the pharmaceutical industry can better leverage its data assets to virtualize the Drug Discovery (DD) process with world-leading Machine Learning (ML) technologies as an answer to the ever-increasing challenges and stricter regulatory requirements it is facing. The lack of a tested, secure and privacy-preserving platform for federated machine learning that enables pharmaceutical partners to extract DD-relevant information from all types of, not only their own but even each other’s competitive data, without mutual disclosure of the chemistry and biology each partner has worked on, has previously held back such demonstration, to the detriment of patients in the EU and beyond.MELLODDY’s ten pharmaceutical partners will enable this demonstration with an unprecedented volume of more than a billion highly private and competitive DD-relevant data points, and hundreds of Tbs of image data that annotate the biological effects of more than 10 million small molecules. The successful demonstration of the predictive benefits, i.e. increased predictive model performance and chemical applicability domain, of unlocking this data volume, while strictly preserving the privacy of all underlying data and the resulting predictive models, will shape best practices and translate into substantial efficiency gains in the DD process, and in the future, drug development. Finally, MELLODDY will prepare and exploit a service-for-fee vehicle to ensure the MELLODDY technologies are available to the rest of the pharmaceutical sector.


**Keywords:** Federated learning, Privacy by design, Deep learning, Distributed ledger technology, Container orchestration, Predictive models, Drug discovery, Activity prediction, ADME prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The molecular physiology and the evolution of a new pathway promoting developmental stability' in the context of a Seventh Framework call.

assistant: **Objectives**

Developmental stability is the ability of an organism to buffer given traits against environmental and intrinsic perturbations. This may involve physiological, temporal or behavioral adjustments to the developmental program. The processes leading to developmental stability have been particularly well studied in arthropods. For instance, if uncoordinated growth is induced in the larval imaginal discs (the precursors of adult appendages) of Drosophila flies, a transient delay in the onset of metamorphosis ensues, allowing extra time for all discs to achieve their species-specific size and proportion. How exactly this exquisite coordination between growth and developmental timing is achieved is not completely understood. Recently, others and us have identified a fly-specific insulin/IGF-I/relaxin peptide named Drosophila insulin-like peptide 8 (DILP8) that responds to uncoordinated imaginal tissue growth and delays the onset of metamorphosis by inhibiting, via an unknown mechanism, the biosynthesis of the major insect molting hormone, Ecdysone. Loss of dilp8 increases intra-individual asymmetry and yields individuals with a greater than normal range of size variation and time of maturation. Thus, DILP8 is a central player in the communication system that mediates the adjustments to promote developmental stability in Drosophila. Here, we plan to identify the mechanism of action of DILP8 and to understand how this new peptide became incorporated into a conserved tissue-stress sensing pathway. To reach these objectives, we will identify the target tissue/s that mediate DILP8 function(s), the signalling pathway that it acts through, and determine when it originated and became responsive to abnormal growth during dipteran evolution. Our results should provide insight into the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ribosome Processivity and Co-translational Protein Folding' (RIBOFOLD) targeting Horizon 2020.

assistant: **Abstract**

Protein domains start to fold co-translationally while they are being synthesized on the ribosome. Co-translational folding starts in the confined space of the ribosomal polypeptide exit tunnel and is modulated by the speed of translation. Although defects in protein folding cause many human diseases, the mechanisms of co-translational folding and the link between the speed of translation and the quality of protein folding is poorly understood. Here I propose to study when, where and how proteins emerging from the ribosome start to fold, how the ribosome and auxiliary proteins bound at the polypeptide exit affect nascent peptide folding, what causes ribosome pausing during translation, and how pausing affects nascent peptide folding. Our recent results (Holtkamp et al., Science 2015; Buhr et al., Mol Cell 2016) provide the proof of principle for monitoring translation and protein folding simultaneously at high temporal resolution. First, we will follow translation processivity and folding trajectories for proteins of different domain structure types using time-resolved ensemble kinetics and single-molecule setups. The structures of complexes with stalled folding intermediates will be solved by cryo-electron microscopy. Second, we will investigate the effects of the chaperone trigger factor, the signal recognition particle, and other protein biogenesis factors on the folding landscape. Third, we will analyze transient ribosome pauses in vivo (based on ribosome profiling data) and in vitro (based on time-resolved translation assays and mathematical modeling) and identify the events that cause pausing. Finally, we will probe how changes in translational processivity affect the conformational landscape of a protein. We expect that these results will open new horizons in und