RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protection against reactive oxygen species in neurodegeneration' under Seventh Framework.

assistant: **Concept**

Oxidative stress (OS) is implicated in the pathogenesis of some of the most devastating neurological diseases. Therefore, identification of pathways that counteract oxidative damage may lead to therapeutic strategies applicable to a wide range of disorders. I have recently identified the importance of the mitochondrial oxidation resistance 1 (Oxr1) gene for neuronal survival; loss of Oxr1 causes neurodegeneration in mice, whereas over-expression in vitro is able to confer protection against OS.Deregulation of this protein is also observed in human ALS and additional mouse models of in neurodegeneration. Despite the apparent high level of conservation of Oxr1-related proteins, virtually nothing is known about their function in vivo. This proposal will establish an independent research programme to understand the role of Oxr1 and related proteins as part of novel pathways that provide protection against both OS and neurodegeneration.Preliminary data I have generated has identified proteins that interact with Oxr1 in neurons; significantly, a number of these binding partners are mutated in neurodegenerative disease. Therefore, using a combination of mutational and biochemical analysis the relationship of these interactions to neuronal cell death will be investigated . Studies will also focus on the role of Oxr1 in mitochondria, examining the significance of this localisation to the control of the OS response. This will be complemented by in vivo studies in the mouse to to determine whether the loss or disruption of Oxr1-related proteins is critical for CNS function.Using the latest techniques in molecular genetics and in vivo modelling this project has major translational opportunities and will provide an excellent opportunity to answer one of the key questions in neurodeg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cold season climate reconstructions from Lakes in the Alpine regions of Switzerland and Sweden' in the context of a Seventh Framework call.

assistant: **Objectives**

Past variations in interannual climatic variability are currently not well understood, mainly due to a lack of temperature reconstructions for the winter season. This proposal aims to provide quantitative data on winter-spring temperatures for two lake sites in the Alpine regions of Switzerland and northern Sweden, since these are likely to contain sensitive archives of past climate change. The reconstruction of winter temperatures in these two regions is highly relevant, since local winter temperatures and precipitation are controlled by the variability and strength of the North Atlantic Oscillation (NAO). Increased knowledge on the impact of NAO in these sensitive mountain regions is crucial for a better understanding of future impacts on e.g. lake ecology, water-and energy supplies and winter tourism. In addition, obtained data can be compared to existing summer temperature reconstructions to study changes in interannual variability.      A novel methodology developed at the host institute is proposed, using Chrysophyte stomatocysts as a proxy for winter-spring temperatures. However, to distinguish between climate-induced changes in stomatocyst assemblages and the impact of other factors affecting lake ecology, such as human influence, a multi-proxy approach is required including the analysis of pollen, C and N ratios, total biogenic silica and sediment grainsize.   At the Swiss site the proposal targets three time periods; I) modern time (AD 1864-present), for validation with measurement data, II) the most intense phase of the Little Ice Age, including the Maunder Minimum (AD 1650-1800) and III) the warmest phase of the Mediaeval Warm Anomaly (a 100 years window, possibly AD 850-950). In Sweden the proposed method has not been applied before, and therefore the metho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced computer aided design of ecological products and technologies integrating green energy sources' (ADEPT).

assistant: **Innovation**

The overall aim of ADEPT project is to develop the research at the University Transilvania of Brasov in the field of design of environmentally benign products and technologies integrating renewable energy sources. This will be achieved through a set of nine accompanying measures devoted to promote the scientific and technological excellence (2 measures - organisation of an International conference and a National Seminara), training of researchers (4 measures - fellowship, PhD, Advanced Summer Institute and study visit) and networking (3 measures - Twinning, European research network and preparing a joint project proposal to be submitted to the European framework programme). The project is expected to lay out strong foundations meant to enable the Product Design and Robotics Department to actively participate in the European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Researchers' Night: The Night Deal' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The Night Deal proposal aims at organising a European Researchers' Night (ERN) event in Nicosia. The proposal's overall objective is to reach out to the wider public and raise awareness about the research and innovation (R&I) activities undertaken at national and EU level while boosting knowledge about the benefits of science to society in order to stimulate the interest in research careers, especially among young people and their families. The Night Deal aims also at promotimg the agenda of the European Green Deal initiative for a greener and smarter world, for a more sustainable future through R&I. The Coordinator, the Research and Innovation Foundation (RIF), as the National Agency for supporting R&I, has within its remit gained a long experience in organising activities for the promotion of R&I towards the public and especially the younger generation, with the ERN events being an integral part of its philosophy since 2006, and always with the vivid support from the National R&I System. The proposed event will be the result of a long-lasting and well established collaboration of the RIF with all relevant R&I stakeholders (government, industry, academia) and participants from the public ensuring maximum complementarity. Building on past experiences, The Night Deal will bring together researchers from all sectors and disciplines, along with the public, increasing appreciation of the researchers’ work, raising awareness on the importance of R&I for society and the economy and motivating young people to take up a career in research. With the motto 'science for all' as a flagship and through pre-events, side and main event consisting of a balanced mix of edutainment and inreactive activities aiming at people of all ages, genders and educational backgrounds, The Night Deal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The first 2500°C industrial furnace, for higher efficiency and up to 5 times higher strength materials' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With nearly 50 years of experience and holding international field offices in China, Japan, Taiwan, Korea, Brazil, Russia, Turkey and Italy, CREMER Thermoprozessanlagen GmbH is one of the world leading companies in industrial furnaces. Always working at the edge of technology, our company is specialized in pusher furnace systems with graphite coating, operating at extremely high-temperatures, above 2000°C. These systems are used in Carburizing processes of powder Carbides, such as Tungsten Carbide (WC).The European economic downturn, that has particularly affected large industrial sectors, impelled the necessary economic recovery. As one of the consequences, the demand for higher strength materials has significantly increased. These materials are required for their longer use-life and higher overall performance, allowing for lower operational costs.One of the most common Carbide powders is the Tungsten Carbide (WC). WC powder is used in many different applications and across multiple large industrial sectors, including  utomotive and Aerospace Manufacturing, Construction, Surface and Underground Mining, Oil & Gas Exploration, as well as in many Manufacturing Industries (e.g. Paper, Textiles; Electronics).The global Tungsten Carbide powder market is expected to grow from 13.60 billion € in 2016 to 22.91 billion € in 2026, at a CAGR of 5.4%. Demand for other Carbides, such as Tantalum Carbide or Niobium Carbide, is also increasing. Tests have proven that Tungsten Carbide (WC) powder produced at 2500°C is 3 to 5 times higher strength than the same material produced at 2200°C. The problem is that, at industrial scale, there are no such furnaces able to operate at 2500°C.CARBIDE 2500 is the first industrial furnace capable of operating at 2500°C, making it possible to produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Proteomic approaches to assess the oceanic nitrogen biogeochemistry' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project “Proteomic approaches to assess the oceanic Nitrogen biogeochemistry – ProteoN” has 3 major research objectives. In summary, these are the development of a novel, high-throughput proteomic approach by combining state-of-the-art mass spectrometric and molecular biological techniques. This unique approach links the metabolic activity of organisms to their identity by assessing the proteins in a given sample. The developed approach will be established using a characterized model system. The novel approach will then be applied to a contemporary research issue of international interest. Specifically, this objective will compare the nitrogen (N) biogeochemistry of two ocean basins and aims at evidence for or against the hypothesis (published in 2007 by peer scientists) that the Pacific is a site of high N2 fixation with higher rates than in the Atlantic Ocean. N2 fixation is the main source of fixed N in the open ocean and is a crucial player in primary production and hence the air-sea exchange of atmospheric CO2. The skills and knowledge acquired at a prestigious research institution in the U.S.A. will be transferred to an excellent research institution in the ERA (MPI Bremen) and implemented into a study on the short-term effect of dust deposition in the North Atlantic Ocean. Atmospheric dust is the main source of iron to the open ocean, a limiting nutrient for N2 fixation. Dust deposition is subject to global change through increased desertification and changing land use and thus of international research interest. Through the combination of research in a third country with the transfer of skills and knowledge to the ERA, present-day, globally-relevant issues can be assessed at the international level in addition to strengthening the individual as well as the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scattering approach to thermodynamics of quantum systems' in the context of a Horizon Europe call.

assistant: **Objectives**

Understanding thermodynamics in the quantum regime involves the understanding of how energy and information are exchanged between a quantum system and its surroundings. Although the laws of thermodynamics are well understood for macroscopic classical environments, advancements in quantum technology press the need for a microscopic approach which treats the surroundings as a quantum system in its own right. This project, which I call scattering approach to thermodynamics of quantum systems (SAT-Q), aims at providing such an approach. It relies on a quantum treatment of the surroundings as particles which travel in space and scatter with a quantum system. The starting point of SAT-Q are state-of-the-art results showing how the scattering approach with massive particles goes beyond existing collision-based approaches to thermodynamics of quantum systems by explaining the notions of heat and work in a fully-quantum fashion. The plan of the SAT-Q is then to extend the scattering approach to situations of greater theoretical and experimental relevance, where particle statistics are important and when incoming particles are photons. This is essential in quantum transport and optics setups, where the scattering approach can be applied. In parallel, the plan of SAT-Q is to establish a connection between the scattering approach and more abstract approaches to thermodynamics based on resource theories, bringing the latter closer to reality. Since scattering is ubiquitous in nature and physics experiments, I expect SAT-Q to produce new, foundational results in the field of quantum thermodynamics which can be directly tested in modern experiments.


**Keywords:** Quantum, Thermodynamics, Scattering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Effects of confinement on inhomogeneous systems' to be submitted under Horizon 2020.

assistant: **Abstract**

The objective of the project is determination of universal features and specific properties of various systems spontaneously ordering into spatially inhomogeneous structures (mobile ions in solids, ionic liquid mixtures, soft-matter and biological systems), with special focus on effects of confinement. There is striking similarity between properties of the above systems despite different interactions and length scales of inhomogeneities. The fundamental relation between structural inhomogeneities and mechanical and thermodynamic properties is not fully understood because the exchange of knowledge between the solid-state, liquid-matter, soft-matter and biophysical communities is limited. Theoretical and simulation approaches developed by 3 EU MS + 1 AC + 2 TC groups are closely connected or complementary. We use mean-field, liquid-matter, DFT, integral equations, field and collective-variables theories, molecular simulation approaches, and experimental methods of electrochemistry. We will share our experience in constructing/modifying, solving and verifying experimentally models for different complex systems.  The new results and theoretical approaches will help in future studies of various inhomogeneous systems. The first work package concerns systems spontaneously forming ordered patterns, from thin films on solid surfaces through particles on interfaces to biological membranes and arid ecosystems. The pattern formation can be exploited in innovative technology. In the second work package we will investigate ionic liquids/ionic-liquid mixtures, especially near charged surfaces and in porous media, and mobile ions in intercalation compounds. Mobile ions and ionic liquids in porous electrodes are potentially important in innovative electrochemistry. EU/TC knowledge trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Translational Kinase Tumour Inhibitor discovery Consortium' (TAKTIC).

assistant: **Concept**

Protein kinases are involved in the control of a large number of cellular processes and play a central role in human physiology. More than 500 genes encoding protein kinases have been identified in the human genome, and it is estimated that about 30% of all human proteins may be phosphorylated by kinases. Deficiency in kinase activity has implications in cancer, central nervous system disorders, autoimmune diseases and immunosuppression, diabetes, osteoporosis and various metabolic disorders. Small-molecule kinase inhibitors have therefore moved into the focus of the pharmaceutical industry as a new class of drugs, which is expected to produce new and more efficient treatments and grow significantly within the coming decade.The proposed project brings together the unique and proprietary technologies of three SMEs and the expertise of academic research partners to create a new platform for lead compound discovery with a focus on protein kinases. Three kinases will be targeted for the development of inhibitory compounds. The academic partners will contribute a modern high throughput platform for protein expression and crystallisation (Israel Structural Proteomics Centre), and expertise in the biochemistry and biology of the targeted kinases combined with the principles of the use of bioisosterism in synthesis of novel chemical compounds (University of Turin). The applied principles and technologies will provide new IP opportunities for the partner SMEs in the otherwise crowded kinase inhibitor IP space and will help in the design of new strategies in the discovery of inhibitors for novel kinase targets in the treatment of cancer. The generated compounds will be sold and/or out-licensed to large pharmaceutical companies for continued development. This market is currently u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In-cavity thermophotonic cooling' under Horizon 2020.

assistant: **Concept**

Thermophotonic (TPX) coolers and generators based on electroluminescent (EL) cooling have the potential to enable a high efficiency replacement for thermoelectric devices. Highly optimized TPX devices can even outperform modern compressor based household refrigerators and heat pumps, enabling a significant reduction in the global energy consumption of cooling and heating. While the EL cooling phenomenon is theoretically well understood, it was only very recently demonstrated for the first time under very small power conditions. Enabling high power EL cooling, however, will require a breakthrough in reducing the losses present in conventional light emitting diodes (LED).iTPX aims to enable this breakthrough by developing an alternative approach to enhance the efficiency of light emission. The approach is based on enclosing the emitter-absorber pair used in TPX in a single semiconductor structure forming an optical cavity. This enhances the light emission rate by an order of magnitude and provides a substantial increase in the efficiency as well as several other technical and fundamental benefits. The main goal of iTPX is to demonstrate high power EL cooling for the first time and to provide quantitative insight on the limitations and possibilities of the cavity-based approach.  Recent studies have shown extremely high – over 99 % – internal and external quantum efficiencies of light emission from optically pumped semiconductor structures. This suggests that the material quality of common III-V compound semiconductors is perfectly sufficient for EL cooling if similarly performing electrically injected structures can be fabricated in the single cavity configuration.