RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developmental Origins of Healthy and Unhealthy Ageing: The Role of Maternal Obesity' in the context of a Seventh Framework call.

assistant: **Objectives**

Europe has the highest proportion of elderly people in the world. Cardiovascular disease (CVD), type 2 diabetes (T2D), sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Obesity is a main health concern in the world. In the EU one-third of women of reproductive age are overweight and 20% are obese, a prevalence predicted to double in the next decade. There is growing evidence that maternal obesity increases the long term risk of CVD, T2D and neurodegenerative morbidity in the offspring. This project will clarify if and to what extent maternal obesity leads to premature and unhealthy ageing, by causing early, i.e. pre-/perinatal metabolic and genetic vulnerability, starting from insulin resistance and glucocorticoid exposure, leading to oxidative-stress, telomere/DNA damage, epigenetic changes, interacting with genetic and environmental variability, resulting in altered gene expression/repair, and ultimately in disease during life and pathological ageing. We will investigate the postulated mechanisms during pregnancy and development, their life long consequences in animal models and in large human cohorts followed from prenatal life until ageing, and the possibility to intervene when the condition is still reversible. Surrogate markers to estimate early risk and monitor progression-regression will be defined. This project will comprehensively address the expected impacts listed in the work programme HEALTH.2011.2.2.2-2 targeting the improvement of health and healthy ageing of a broad/broadening European population. The participation of a research intensive SME and European NGOs guarantees success in biomarker discovery-innovation and in dissemination-public preventive programs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of crosslinked flexible bio-based and biodegradable pipe and drippers for micro-irrigation applications' (HYDRUS).

assistant: **Innovation**

The Southern Accession countries and Southern EU countries use the largest percentages of abstracted water for agriculture (75 % and 50 %, respectively), primarily for irrigation. This means consume of 120.000 Millions of m3/year of water. The use of micro irrigation system can reduce the water consume in near 60%, i.e., reduction in consume of 70.000 millions of m3/year. Furthermore, this market is expected to grow quickly due to new water regulations in the near future (due to the worrying problems of the desertification and longer periods of drought).Despite the benefits that the micro-irrigation systems present, there are some limitations that burden its use by the farmers:  a).High cost to remove the product at the end of its useful life (even higher in combination with mulching system) and b). Non recyclable pipes due to its conditions of use the material losses its mechanical properties by the effect of UV radiation, is chemically attacked and has contaminants. The aim is to develop plastic pipes and drippers for micro-irrigation produced with bio-based and biodegradable material which will maintain their functional properties during lifespan and at the same time biodegrade after use without the need to remove and dispose. HYDRUS approach will consist on two-step process:1.Reactive extrusion: A low module biopolymer and/or polymeric plasticisers and graft coupling agents will be added to the current PLA, using a compounding multi screw extruder.2.Extrusion pipe line+ crosslinking(standard equipment): Addition of organosilanes or peroxides to the previous blend (PLA + additives) and production of the pipe. The same process will be applied for the drippers with standard injection moulding machines. The new pipe will show Good thermal,Environmental Stress Cracking a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stimulation of reverse cholesterol by somatic gene transfer' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content There is an inverse correlation between incidence of atherosclerosis and the HDL levels. This protective activity of HDL is generally attributed to its role in the reverse, cholesterol transport, mechanism by which peripheral cells transport cholesterol excess to the liver to elimination through the bile. And so, reverse cholesterol transport seem to be a good potential therapeutic target for treating atherosclerosis. In the project, we want to enhance reverse cholesterol transport using somatic gene transfer by overexpression of apoA-I (the major protein of the HDL) in the liver and validate reverse cholesterol transport as a therapeutic target in gene-therapy for atherosclerosis. This will be made after construction of plasmid and adenoviral vectors with gene insert of apoA-I, and transfection into cultured cells or atherosclerotic animal models. We will follow apoA-I concentration and expression level of apoA-I gene to verify the overexpression expected. Then, we will look for the impact of this overexpression at the metabolic and physiological levels. Transfected cells and animals will be used for cellular cholesterol efflux measurements. The lipoprotein profile, LCAT activity (and biliary secretion of cholesterol for the animals) will be studied on these models, accompanied by a physiological study of the atherosclerosis development on the animals. Training content (objective, benefit and expected impact) This project will allow us to validate reverse cholesterol transport as therapeutic target in gene-therapy for atherosclerosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New Insights into Language Processing and Change By Investigating Tactile Sign Language' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Extensive research over many decades has illuminated the human capacity for language through the study of spoken languages. In the past 20 years research into visual sign languages have provided us with important and unique insights into human language that could not have been obtained by studying spoken languages alone (Emmorey, 2023). For example, we now know that visual sign languages are just as linguistically complex as spoken languages and that developmental and/or acquired language disorders can impact visual sign language perception, production and processing (Mason et al., 2010). We also know that areas in the brain used for spoken language processing are also recruited for visual sign language processing (MacSweeney et al., 2008). Language can also be perceived through touch: the tactile modality. Some deafblind individuals communicate using tactile sign language, as spoken and visual sign languages may be inaccessible for them. There is some linguistic documentation of tactile sign language in countries such as Sweden (Mesch, 2001), the USA (Edwards, 2017) and India (Kusters, 2017). There is still a dearth of research on tactile sign language in the U.K, and worldwide, and compared to spoken and visual sign languages (Simcock et al, 2024). Studying tactile sign language may lead to valuable insights into the nature of human language. This deeper understanding of tactile sign language will enhance our ability to support deafblind individuals and promote their fuller participation in society. To gain those insights, I propose a novel, multidisciplinary and ground-breaking approach where I will document tactile sign language in British deafblind individuals using linguistic ethnography and corpus linguistics methodologies. I will also use a state-of-the-art func
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unraveling the molecular mechanisms leading to cellular dysfunction in diseases linked to defects in mitochondrial iron-sulfur cluster metabolism' to be submitted under Seventh Framework.

assistant: **Abstract**

The project aims at unraveling the molecular pathophysiology of recessive ataxias, a heterogeneous set of severely disabling neurodegenerative disorders due to loss of function of proteins involved either in mitochondrial/metabolic pathways or DNA repair. Friedreich ataxia, the most common form, is due to partial loss of function of frataxin, a mitochondrial protein involved in iron-sulfur cluster (ISC) biogenesis. Furthermore, the rare X-linked sideroblastic anemia with cerebellar ataxia is caused by mutation in ABCb7, an ATP-binding cassette transporter of the mitochondrial inner membrane necessary for cytosolic ISC export. ISC are versatile co-factors of proteins involved in electron transport, enzyme catalysis and regulation of gene expression. The synthesis and insertion of ISC into apoproteins involve complex machineries that are still poorly understood in the mammalian cell. The objectives of this proposal are: 1) to elucidate ISC biogenesis and metabolism in the mammalian cell, with an emphasis on the role of frataxin and ABCb7; 2) to better understand the molecular pathways that are involved in neuronal dysfunction due to defects in mitochondrial ISC metabolism. These objectives will be accomplished by a multidisciplinary approach combining molecular and biochemical approaches to study the ISC assembly machineries, bioinformatic and proteomic studies to identify new Fe-S proteins, the development and pathological analysis of animal and cellular models to dissect the molecular mechanisms, and transcriptomic analysis to uncover the common pathways among recessive ataxias. A specific focus of the proposal will be the involvement of DNA damage response pathways in neuronal dysfunction, as several DNA repair enzymes have recently been identified as Fe-S proteins and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'BIOdiversity over Microevolutionary and Macroevolutionary scales: Evolutionary and ecological determinants revisited' (BIOMME) under Seventh Framework.

assistant: **Objectives**

Evolutionary biologists have long sought to understand the relationship between microevolution (processes within species), as observed in nature and the laboratory, and macroevolution (processes at and above the species), which occurs over intervals that far exceed a human lifespan. They have also long endeavoured to determine which factors – whether abiotic like climatic or geological changes (Court Jester), and/or biotic like species interactions, traits, or niche space (Red Queen) – govern biodiversity dynamics. The connection between these factors and processes within and among species has become a major source of dichotomy between population genetics and phylogenetics. This project constitutes a unique opportunity to address this gap and to assess whether similar evolutionary and ecological processes govern tempo and mode of evolution in swallowtail butterflies. The research will make four relevant contributions: (1) building a unique dataset for swallowtail butterflies that includes genomic, morphological, ecological, geographic and paleontological data to further investigate processes at each evolutionary scale; (2) using genomic data and phylogeographic analyses to test speciation theories by investigating the determinants of species formation within selected species-groups; (3) using the ecomorphological dataset and time-calibrated phylogenies to understand macroevolutionary determinants of large-scale patterns of biodiversity, and (4) using all the data to explore the link between micro and macroevolution in a novel framework. The University of Alberta and Real Jardín Botánico have a strong tradition of using large datasets to answer questions pertaining to patterns of evolution and ecology. Thus, the integration of many layers into a conceptual framework, at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Datafied living: pursuing human flourishing through mundane self-tracking across personal, work and institutional contexts in the welfare state.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Datafied living develops a communication-centric conceptual and empirical research agenda on the relationship between infrastructures for tracking of the self and forms of agency and meaning in datafied living. It focuses on the mundane experiences and implications of voluntary, pushed, coerced and imposed forms of self-tracking that unfold as we practice ourselves and pursue the good life through digital media. Despite a general, growing scholarly and public concern about the power that big tech companies have amassed in shaping societal developments and individual life possibilities through datafication, we lack knowledge about how exactly datafication is experienced, what it means to ordinary people, and how it shapes diverse contexts of everyday life. Such knowledge is crucial to intervene in tech development and its regulation in support for human flourishing: in facilitating good, safe and meaningful datafied living for all. Datafied Living is groundbreaking in five respects: 1) by framing datafication as conditioned on communication, I develop a novel communicative framework that cuts across domains of application and significantly advances both communication theory and datafication research; 2) I cover uncharted empirical territory of “datafication as viewed from below”, unifying data-driven and classic methods in an ambitious, context-sensitive methodology to study infrastructures and experiences of self-tracking and tracking of the self by others across personal, work and institutional life in the welfare state of Denmark, one of the most digitized and datafied countries in the world; 3) I unify and synthesize infrastructural analyses and experiential perspectives to elicit agentic potentials of mundane self-tracking across contexts; 4) I bring a much needed E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Orchestrating Information Technologies and Global Systems Science for Policy Design and Regulation of a Resilient and Sustainable Global Economy' to be submitted under Seventh Framework.

assistant: **Abstract**

Over the last few years, the greatest concern of the global political agenda has been to find a way to overcome the crisis and therefore to look for effective policy instruments and even for new theoretical economic frameworks. Some effort has been made in order to respond to this concern, but we still miss adequate tools for exploring and governing the complex global dynamics of our economic and social system. On the top of the urgency to find a way out of the crisis, and to prevent future crises by making the global economy more resilient, we need new tools to explore the possibility of broad societal transitions to sustainable patterns of production and consumption. In particular, it is crucial to explore financial sector regulations and macroeconomic policies that help to trigger these sustainability transitions.<br/>SYMPHONY aims at providing a set of innovative ICT tools, integrated in a platform designed to tackle these pressing issues. The work will be developed in strict cooperation with stakeholders and policy-makers, involved in the project to devise appropriate scenarios and modelling requirements. The main objective of the project is to develop a framework for designing and testing policies and regulatory measures regarding:- preventing and mitigating economic and financial crises;- fostering an economically and ecologically sustainable growth path.<br/>SYMPHONY's strategy to successfully accomplish its mission is to orchestrate a set of tools that will be able to:- collect and analyze relevant information by means of social media mining tools and web-based information markets;- simulate the complex economic dynamics by means of an agent based model of the global economy, explicitly designed for policy making;- involve citizens in the decision making proces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Perspectives On socio-economic practices at the Transition of the neoliThic and eneolithic periods through the INterdisciplinary investiGation of ceramic life cycles' (POTTING) targeting Horizon Europe.

assistant: **Abstract**

Pottery is one of the paramount materials found in archaeological excavations in Central Europe, and as such it has been used to track regional chronologies, stylistic trends, and distribution patterns. Recent developments in archaeological pottery analysis, however, focus on broader interpretations of the socio-anthropological dynamics behind pottery production by championing an approach based on the chaîne opératoire concept, i.e. the sequence of technical steps in pottery-making, shaped by learning and transmission. Building on this concept, the POTTING project will provide a novel framework to understand continuity, transformation, and change in prehistoric socio-economic practices at the pivotal Neolithic-Eneolithic transition in Moravia, by remarkably taking into account not only production technology, but also pottery use. Thanks to the long occupation over a time span of more than 1000 years at the Moravian site of Brno Modřice-CTP, the project will unlock socio-economic practices across multiple cultural horizons at a single site, offering unparalleled control over environmental and geographic variables. The analytical framework combining ceramic petrography and micro-CT coupled with the multi-scalar analysis of manufacturing traces, completed by lipid residue analysis to investigate the actual use of pottery, will unveil domestic practices and related economic activities, including raw material prospection, pottery-making, storage, cooking and food consumption practices. Leveraging the expertise in Central European prehistoric material culture offered by the host institution (Masaryk University), and the recent advances in imaging and biomolecular approaches on archaeological pottery brought together by the consultants from partner institutions, the fellowship
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent' under Seventh Framework.

assistant: **Concept**

Visceral leishmaniasis (VL), one of the most-neglected infectious diseases, has an annual incidence of 500,000 cases. Early treatment is a major pillar of the current program for VL elimination on the Indian sub-continent. However, the arsenal of available drugs is very limited, and their use is jeopardized by drug resistance. Combination regimens for VL are under clinical development, but it will take several more years to change the drug policy. Meanwhile, the effectiveness of current drugs needs to be safeguarded in order to cure patients and ensure unremitting sustainment of VL control. For this, the uninterrupted supply of quality drugs, the promotion of treatment compliance and, the monitoring of treatment effectiveness and of drug resistance will be pivotal. The latter demands improved knowledge and know-how, hence clinical and laboratory research are urgently needed to support the drug policy of the VL elimination program. The present multi-disciplinary proposal addresses these needs: we aim to develop, evaluate and disseminate new tools for the assessment of drug resistance in L. donovani as well as innovative methodologies for monitoring Kala-Azar treatment effectiveness under routine conditions.