RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strengthening Technology, Research and Innovation Cooperation between Europe and South Africa 2020' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The STI cooperation between the EU and South Africa as originally framed by the South Africa-EU Scientific and Technological Cooperation Agreement and as constantly steered by the JSTCC requires a support mechanism which can translate and facilitate policy decisions, and provide intelligence and information services to various actors and stakeholders. In previous years the ESASTAP project series (ESASTAP, ESASTAP-2 and ESASTAP+) has successfully provided this support to the bilateral dialogue. The proposed ESASTAP 2020 project is a coordination and support action that aims at advancing further the EU-SA bilateral STI cooperation, building on the work and results of three preceding actions and responding to the needs and recommendations at the policy dialogue level, in particular to the mandate of the JSTCC and to the adopted Roadmap for cooperation between South Africa and the European Union. The project aims to provide efficient services on three levels (priority areas):a.R&I Cooperation in areas of common interests (Horizon 2020 and others). b.Policy Dialogue between EU and SA and by increasing the knowledge of the EU’s external environment.c.Provision of a Cooperation platform and tools to alleviate obstacles.These priority areas translate into four major objectives through which the project is aiming to address the specific challenges of the call.


**Keywords:** STI Cooperation, EU, South Africa, Horizon 2020, Innovation partnerships, support, policy dialogue, reciprocity, societal challenges, socio-economic impact, dissemination, stakeholder outreach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Using a computer environnement to improve the quality of algebra education at different school levels'.

assistant: **Objectives**

It is well known that Education is one of the key elements of every society. A worldwide scale look at of the economic, social and financial health of the different countries clearly shows an intimate link between the expansion of the latter and the degree of expertise of its protagonists, which directly depends on the quality of the given training.Therefore, in a society more and more competitive, education plays a crucial role and looking for its improvement cannot be done without seeking the improvement of th e quality of the educators. Researchers in Mathematics Education, with the aim of improving the teaching of this discipline, which still poses many problems, are interested in analysing the malfunctioning of the learning of Mathematics, by the means of designing and analysing tasks proposed to students on different school levels.More particularly, in our project we are interested in investigating how students perceive one mathematical concept that underpins all mathematical domains: algebra and its symbols. In fact, the relation one has to symbolism not only plays a crucial role in learning process, but mastering symbolism is also unquestionably a sign of some mastery of mathematics. Studying the relations students have to symbolism is therefore of major importance in educational research. We chose the University of Melbourne and the Universite Paris 7, two internationally renowned institutions in the field of mathematics education to carry out the present project.Throughout this project, we intend to develop algebraic tasks for students in Australian elementary schools (including tasks designed in a computer environment specially conceived for this purpose) and compare them to the French researches developed so far. Thus, by analysing algebraic skills of studen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Corporate Open Disclosure: A Defensive Perspective' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The research I intend to carry out will shed some systematic light on the strategic motives that lead companies to disclose openly technical knowledge. Put poorely, open disclosure means that companies do not attach any form of property rights to it, like in the case of patents or formal contractual agreements. This behaviour is against the traditional justification of intellectual property rights – especially the patent system – where inventors are granted temporary monopoly over their inventions in exchange for the disclosure of the technical details of the latter. Yet, in a strategic setting, companies might be willing to disclose knowledge openly in order to block rivals’ future patent applications and hence secure their own competitive position. Recent examples of companies promoting open disclosure abound, from the field of software and electronics to genomics. The investigation of this phenomenon is rather scarce and has mostly remained theoretical and anecdotic. This project will draw from the existing contributions in theoretical Industrial Organization, IPR Law, Innovation Management and recent advancements in bibliometric (publication data) studies to derive theory-informed predictions and provide the first systematic empirical evidence of the extent and effectiveness of open disclosure strategies. Its first aim is to build a comprehensive database which meaningfully links measures of open disclosure to firm-level innovation strategies, financial and innovation performance. The subjects that will be investigated are the effectiveness of different measures of open disclosure to prevent competitors obtaining IPRs, the relation of open disclosure with other appropriation strategies such as patents and secrecy, and the competitive settings in which this strategy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hacking Photosynthesis: Biosensors for Herbicides and Beyond' (B-FHAB).

assistant: **Innovation**

The introduction of agrochemicals has drastically improved crop yields, largely thanks to the use of herbicides that kill crop competing weeds. Unfortunately, herbicides residues often find their way into our ecosystems, drinking water and food. Current means to monitor herbicide residues utilize expensive, time-consuming methodologies such as liquid chromatography coupled to mass spectroscopy, a technique typically restricted to First world countries and trained users. A biosensor provides a means for rapid, low-cost, sensitive herbicide detection that is widely accessible even in developing countries. I have previously evaluated a biosensing platform using an electrode coated with bacterial reaction centres, but found that it was not sensitive enough to meet EU drinking water standards, was limited to sensing a small class of herbicide residues and was not stable enough under storage for widespread distribution. To tackle the issue of low stability, I implemented a redox polymer transduction matrix, resulting in biosensor stability for hours during operation and months in storage. I then approached the most challenging aspect of boosting biosensor sensitivity by re-designing the biological recognition element itself, using docking simulations to guide enzyme design that resulted in validated improvements in biosensor sensitivity in the lab. This forms the platform for my research within the MSCA Postdoctoral fellowship, wherein I seek to push enzyme-herbicide binding affinities to reach a biosensor sensitivity that meets EU standards, expand the scope of sensing beyond a small class of  residues, and sense not just single but multiple herbicide residues on a single test strip. The results of this work will lead to a herbicide biosensor that approaches market viability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling solution for complex software systems', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

MODELPLEX has three major objectives:- Objective A: Develop an open solution for complex systems engineering improving quality and productivity;- Objective B: Lead its industrialisation;- Objective C: Ensure its successful adoption by the industry.Model-driven engineering (MDE) is an approach that is gaining acceptance in several software domains with proven benefits such as cost reduction and quality improvement. However, applicability to complex systems engineering still remains a challenge. This is despite complex systems having an even greater need for model-based approaches because models can provide the necessary abstractions that enable human comprehension, communication, simulation and analysis, and synthesis of implementation artefacts for such systems.MODELPLEX will define and develop a coherent infrastructure specifically for the application of MDE to the development and subsequent management of complex systems within a variety of industrial domains, where complexity is characterized by a combination of size, heterogeneity, legacy system management, dynamicity, distribution and autonomy of systems.MODELPLEX will use established MODELWARE technologies as a basis for providing this second-generation MDE approach to solving complex systems engineering problems and will combine substantial innovations in model engineering technology, validation and verification, as well as system management and control. MODELPLEX is organised into two phases of 18 months, each phase delivering significantly innovative and implemented open solutions. The first phase will build and deliver appropriate MDE solutions for complex systems and prepare their consolidation within selected industrial domains.To achieve the objectives, a consortium of 22 complementary partners of internatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MODeling the EnviRonmental and human health effects of Nanomaterials (MODERN)'.

assistant: **Innovation**

Nano-sized materials are a common element in many industrial processes mainly due to their unique properties that lead to the production of high technology products. The widespread use of nanotechnology requires the consideration of the environmental and human health risks that may result from the introduction of engineered nanoparticles (eNPs) into the environment. Although toxic effects for certain types of eNP have been recently reported, there is still a lack of knowledge about their possible long-term effects in biological systems.The project focuses on the understanding of the processes governing the interactions of nanoparticles with biological systems and their associated mechanisms of toxicity, which are essential for eNP safety assessment. Information on the effects of well characterized eNPs will be obtained from literature and other data repositories. Targeted in vivo and in vitro experiments will be also carried out to overcome the limitations of data availability and for model validation. Computational methods will be applied to model both nanostructure-property relationships and the complex and highly non-linear nano-bio interactions and to diminishing the need for animal testing.The main goal of MODERN is to establish new modeling approaches suitable for relating nanotoxicity with the intrinsic molecular and physicochemical properties of eNPs at environmental exposure levels and to implement safe-by-design nanoparticle design strategies. This implies three specific objectives: (i) To apply computational models for the characterization of the structural and physicochemical properties leading to QNPRs and safe-by-design strategies for eNPs; (ii) to develop in silico models (QNAR) of biological activity of eNPs in the body and in the environment; and (iii)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synthetic species of the mosquito vectors of human disease: from hybrid genetics to a new type of vector control' to be submitted under Seventh Framework.

assistant: **Abstract**

In this project I aim to generate the first synthetic species of mosquitoes derived from Anopheles gambiae, the main vector of malaria, and also from Aedes albopictus, a vector of several viral diseases, that has recently invaded Europe. The experimental generation of artificial species will prove invaluable to shed light on major biological questions concerning reproductive isolation. Furthermore, I propose a novel strategy to reduce the incidence of disease transmitted by these vectors based on the release of synthetic strains. Mathematical modelling indicates this to be a highly effective way to simultaneously suppress and replace a wild disease transmitting vector population with disease-refractory insects.In Objective 1, I will identify genes that constitute the natural reproductive barriers in mosquitoes by analyzing the genetic makeup of progeny arising from crosses of related mosquito species. Such genes can be drawn upon for the construction of artificial barriers and help to reveal the mechanisms underlying speciation in mosquitoes.In Objective 2, I will introduce, into the mosquito genome, artificial reproductive barriers that cause post-zygotic lethality in hybrids but that will not otherwise affect the mating propensity of parent and synthetic species. I propose a generalizable approach for the construction of artificial species barriers utilizing synthetic transcriptional activators.In Objective 3, synthetic strains will be transformed with genes that interfere with the replication of malaria or viral pathogens and their transmission to humans and tested in cage experiments to validate their efficacy for vector control.To carry out these experimental activities I will utilize cutting-edge next generation genetic mapping and site-specific genome-editing tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gating cell force sensors with tailor-made nanoswitches to restore tendon tissue function' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

It’s becoming increasingly clear that a deeper understanding of tendon mechanobiology is required for the development of effective therapies for tendon injuries and diseases. The involvement of specialized cell force sensors, such as PIEZO channels, on the mechanosensory processes through which tendons sense and adapt to mechanical loading have just started to be unveiled. Decoding the underlying mechanisms governing these processes would promote the development of innovative therapies to restore tendon function. However, a remaining barrier to unlock the therapeutic potential of PIEZOs is how to effectively target and gate these complex mechanoreceptors in different tendon cell populations (both in vitro and in vivo) and what are the actual biological feedbacks of its activation.FORTFy ground-breaking concept will merge molecularly imprinting technologies and magnetic systems to establish a versatile wireless platform of tailor-made abiotic nanoswitches for the programmed manipulation of PIEZO receptors. Combined with a new generation of advanced tools, including humanized 3D microphysiological systems enabling to study the multicellular crosstalk occurring in tendon microenvironments and to obtain improved bioengineered tendon grafts, it will enable to explore the full potential of PIEZOs as targets for treatment of tendinopathy. The challenging ambition of FORTFy will be accomplished by implementing a thorough in silico, in vitro and in vivo research plan aimed at probing the role of PIEZO-mediated mechanosignaling on tendon homeostasis, degeneration and aging, focusing the neurotendinous crosstalk and its immunomodulatory signatures. The success of FORTFy will not only lead to unprecedented nanomedicine tools for treatment of tendinopathy, but its fundamental concep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative patented dry fermentation technology for cost-effective and highly nutritious production of hybrid mycelium-plant meat analogues'.

assistant: **Concept**

In a public enquiry made by the European Commission, 80% of respondents were willing to reduce their meat intake to help reduce the emission of greenhouse gases (GHG), and 74% intended to change their diet to improve their health. However, current meat analogues in the market are not a healthy alternative, since they are ultra-processed, full of binders and additives, and among their ingredients, we can find high amounts of sugars and sodium, maltodextrins or soy isolate, that are not indicated for a healthy diet. In addition, these products are nor ecological, since they are highly resource-demanding, mainly in terms of water consumption, wastewater generation and energy use, and also cause important GHG emissions. On top of that, the existing meat analogues are rejected by consumers due to their off-taste & bad texture that does not resemble to meat.In response to this situation, Millow has developed to TRL6 a novel solid state dry fermentation production technology for mycelium-plant meat analogues. This highly scalable and cost-effective innovative process accelerates mycelium growth from most typical 3-7 days periods to <24h, reducing required water input by 97%, energy use requirements by 67%, and CO2 footprint by 95% compared to benchmark methods based on liquid fermentation. The resulting products have neutral taste, pleasant texture that mimics meat attributes without the use of artificial binders, is minimally processed, healthy, nutritional and eco-friendly.In the MEATLOW project, we aim to optimise and automate its innovative technology to reach TRL8 and commercial status, and introduce our disruptive plant-fungi products in the EU meat substitute market by 2026. To do that, our highly skilled team of scientific, management and marketing professionals is det
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'LeukoPredict: an in vitro system predicting and monitoring the therapeutic response of patients in the cure of Chronic Myeloid Leukemia (CML).'.

assistant: **Objectives**

Chronic Myelogenous Leukemia (CML) is a blood cancer that affects every year more that 12000 patients in Europe and in the USA. Most CML cases are caused by Bcr-Abl, an abnormally active protein that confers tumorigenic capability to blood cells. The introduction of Imatinib, a Bcr-Abl potent inhibitor, revolutionized CML therapy, transforming this life-threatening cancer into a controllable disease. Approximately 30% of patients, however, display resistance to Imatinib and develop aggressive blood cancer. Here we propose a diagnostic kit (LeukoPredict) aimed to recognize resistant patients before the beginning of Imatinib therapy and address them to a personalized therapeutic alternative. Moreover, this test will be able to monitor the occurrence of newly acquired resistance after therapy initiation, allowing clinicians to prescribe only those drugs that demonstrate maximal efficacy. In the long run, we expect that LeukoPredict will become the gold standard to rationally define the CML therapeutic course, improve the survival of patients and limit the costs sustained by the healthcare system.