RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and expansion of the comprehensive data-base for electronic dissemination and structure-related research' (1994-1998).

assistant: **Innovation**

The main objective of this project is to bring to the public domain, using modern internet protocols, BRENDA, the most complete existing collection of experimental data on enzyme physical-chemical and functional properties, and to integrate it with other key available databases containing information on genome and protein sequences, on tissue and cellular location, and organisms. Another important objective of this project is to include in this system additional, not readily available information. This information pertains to the detailed characteristics of the molecular interactions in 3D structures of enzyme-ligand complexes, and of enzyme active sites, and to detailed structural and chemical descriptions of the small molecules (substrates, inhibitors, effectors) that interact with each enzyme. BRENDA has been developed by partner 1 (Schomburg), first at the German National Centre of Biotechnology in Braunschweig and now at Cologne University. It includes information on all enzymes classified to date(see appendix 2, 2.7 for a typical data set on one enzyme); it is presently held in a pseudo-relational database system in house and is available only in printed form (see references). In order to make this available via the internet, the present data has to be split into molecule-specific information that is directly connected with enzyme sequence and 3D-structure data. In the present form, the data bank has links to the sequence data banks and PDB but the information is integrated under the umbrella of the EC-number (EnzymeCommission number) with an indirect link to the individual enzyme via literature references. This assignment and verification of the current enzyme data in relation to individual organisms/tissues and establishing procedures for its continued up-dating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Linking mechanics and endoreduplication with tissue folding' (MendoFold) under Horizon 2020.

assistant: **Objectives**

Tissue folding plays a key role in the development of all multi-cellular organisms. The aim of this MSCA-IF fellowship is to decipher the poorly understood mechanisms involved in regulating tissue folding in plants, using the apical hook as a model. The hook forms via tissue folding driven by differential cell elongation in the embryonic stem (hypocotyl) and is critical for the survival of young seedlings, since it protects the shoot apical meristem from damage as it passes through soil during seedling germination. Work in the host lab has recently shown that endoreduplication (DNA replication without subsequent cell division) is involved in hook development. Since plant cells are enclosed by rigid cell walls, it is hypothesized that tissue folding during apical hook formation involves an interplay between endoreduplication, cell wall mechanics and hormonal signals which will be deciphered by Dr. Yuan Ma during this fellowship. Simultaneously, Dr. Ma will receive training in cutting- edge techniques like atomic force microscopy, flow cytometry, and immunocytochemistry in leading environments such the host lab at SLU/UPSC (Umeå, Sweden) and via secondments to VIB (Ghent, Belgium) and ENS (Lyon, France). Synergistically complementing skills in biochemistry and genomics gained during his PhD, this training will provide Dr. Ma with a unique technical and theoretical expertise in experimental biomechanics, strongly promoting a successful achievement of the project’s goals, opening of new vistas in developmental biomechanics, and support the researcher’s ambition of becoming a research leader. The researcher will follow a personalized career development plan, to also enhance skills such as communication, grant writing, public engagement and student mentoring. Thus, this MSCA-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improving research and innovation to achieve a massive integration of solar renewables' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The project TwInSolar aims at strengthening the research and innovation capacities of the public laboratory PIMENT of the University of La Reunion (UR), which is located in one of outermost regions of Europe. TwInSolar will create new opportunities inside and outside of Europe and more specifically in the zone surrounding Reunion Island and in insular territories that face similar challenges. This capacity building will be done through the establishment of effective partnerships with the Technical University of Denmark (DTU) and the Fraunhofer Institute for Solar Energy Systems (Fraunhofer), which are internationally renowned research organizations. The dissemination and outreach of TwInSolar will be achieved with the support of the Conference of Peripheral Maritime Regions (CPMR) and the regional R&I agency of Reunion Island (Nexa). Particular emphasis will be placed on issues related to the massive integration of solar energy production in insular territories.


**Keywords:** solar, renewable, grid integration, smart management, regional outreach, international dissemination, isolated areas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hierarchies and information processing in firms organisation' (1994-1998).

assistant: **Innovation**

Research objectives and content The relationship between, on the one hand, the way information is processed and communicated, the ordering in which decisions are taken and, on the other hand, the choice and performance of an organisation is the core of the research proposal for my post-doctoral training. My motivation to conduct research in this field is twofold: first, little research has still been done on this theme; second, understanding the role of information processing in firms' organisation is the natural extension of my PhD thesis, entitled 'Networks, Innovation and Gr'. hMy PhD thesis presented a formal analysis of the impact of telecommunications usage on firms' organisation and productivity. Based on this work, I would like to analyse the impact of communication flows on the performance of two hierarchical structures, the M-form and U-form, and to show that these structures have different ways to organise information exchanges among production units. My research work is thus intended to show that hierarchies usually thought as the epitome of the centralisation of authority, are also remarkably efficient in organising communication flows. Training content (objective, benefit and expected impact) My objective is to formalise a model that can offer complementary explanation on the functioning of hierarchies and firms' internal organisation. In particular, it-will help in understanding how the distribution and the communication of information among agents in firms' internal organisation is one of the crucial determinant of firm's performance. The training I request will allow me to improve my background in organisation theory and to disseminate the results of the research done in the context of my PhD thesis Links with industry / industrial relevance (22) Teleco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'GURNEY FLAP ACTUATOR AND MECHANISM FOR A FULL SCALE HELICOPTER ROTOR BLADE'.

assistant: **Objectives**

Microtecnica SrL (MT) have brought together industry leading expertise to support the design anddevelopment of a full scale Active Gurney Flap (AGF) system. The team have a combination of relevant experience in blade actuation across a range of technologies together with significant capabilities in fundamental engineering analysis to support a comprehensive review of potential solutions. The proposal reflects the joint desire of offering a risk managed baseline approach as well as ensuring all potential candidate solutions are assessed as part of the initial development task.The consortium is lead by MT who provide the technical and programme management and the detail design and manufacture of the wind tunnel and whirl test hardware. MT will be supported by Microtecnica Actuation Technologies (MAT), University of Bristol and the “Politecnico di Torino” based in Turin. The team ensures a balance of technical depth together with a commitment and capability to exploit technology for commercial gain.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Coordination in constrained and natural distributed systems' under Horizon 2020.

assistant: **Concept**

In recent years, an algorithmic theory of natural and biological systems has been increasingly advocated as providing a much needed framework for investigating complex self-organising processes in nature. This project contributes to this research program by employing the distributed computing lens to model natural phenomena. Biological systems exhibit many properties also studied in distributed computing: they comprise several independently acting entities, tend to operate in noisy and dynamic environments, thus requiring them to be highly-resilient and adaptive, solve intricate coordination tasks, and display sophisticated communication techniques.This project aims to develop the theory of distributed synchronisation and coordination tasks in restricted models of distributed computing. These tasks are some of the most fundamental problems in distributed computing, as they are essential in computer networks as well as numerous other areas of engineering and computing. In addition, they are ubiquitous in natural and biological systems, ranging from molecular to population-level systems, which are known to solve various synchronisation and coordination tasks: examples include symmetry-breaking during the development of the nervous system, consensus decision making in species communities, and synchronisation in firefly populations and embryonic development.Unlike computer networks, biological distributed systems have unique features: (1) the agents typically have limited computational abilities, (2) communication is unreliable and restricted, (3) the system has a dynamic spatial structure, and (4) the environment may be noisy. Currently, distributed computing models that consider all aspects simultaneously are lacking. The proposed research approaches this goal from multip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Photoswitching molecules for the spatiotemporal control of cancer stem cells with light' (PhotoStem).

assistant: **Innovation**

PhotoStem aims to develop a cutting-edge approach to overcome the main cause of patient relapse in cancer treatment. Cancer stem cells (CSCs) are a small population of cells within a tumour characterised by their ability to self-renew and to induce tumourigenesis. Current chemotherapy acts only on the bulk of the tumour mass, leaving CSCs unaffected; this is thought to be the main cause of resistance to cancer treatment. Despite growing knowledge on the existence of CSCs, similarities to normal stem cells challenges the design of selective inhibitors and modulators. Relapse to cancer treatment is an enormous challenge and there is an urge to identify novel therapeutic approaches to target CSCs.Photopharmacology is an emerging field that seeks to precisely control the activity of bioactive molecules with light, allowing for activation or repression of biological function at a specific space and time. It constitutes a truly disruptive innovation that can represent a new direction in drug therapy. We herein propose to use novel photoactivable molecules to target CSCs with precise spatiotemporal control using light. Initially, we will develop novel photoswitchable versions of known inhibitors, and will study their effect in leukemia stem cells both in vitro and in zebrafish models. We will then expand our learnings to target CSCs of solid tumours.The achievement of such an ambitious objective will only be possible via a network of multidisciplinary researchers. The researcher will combine her expertise in drug discovery and leukemia with state-of-the-art photopharmacology techniques from leaders in the field at the host institution. Training-through-research at the partner organisations that include well-recognised experts in haematological malignancies, myeloid zebrafish m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Observation of the Higgs production mode in the ttH channel at ATLAS' (ATLASTTH).

assistant: **Concept**

On the 4th of July 2012, the ATLAS and CMS experiments at CERN independently announced the discovery of a “Higgs-like” particle. This remarkable discovery is of tremendous importance to our understanding of the Universe. The discovered particle cannot yet be confirmed as the Higgs boson because several of its properties must be measured and compared with the theoretical predictions.In the proposed programme, the fellow aims to address the nature of the “Higgs-like” particle by measuring some of its properties by analysing the proton-proton collision data collected by the ATLAS experiment. He will work on the observation of Higgs production in association with a pair of top quarks (ttH) followed by the Higgs decay to bottom quarks (H->bb). The observation of this challenging channel will be possible with the large dataset being accumulated in 2012. The analysis performed on this channel will contribute to the measurement of the Higgs coupling to the top and bottom quarks. The fellow will use the same channel to measure the CP parity of the particle, a key parameter for confirming its nature.The fellowship will be carried out in the Particle Physics group within the Physics Department at Royal Holloway University of London. The group was one of the founding members of the ATLAS collaboration in 1992 and has a broad research programme. In particular the host has a strong experience in Higgs and top physics which are both relevant for the project.This fellowship will allow the candidate to restart his research career in particle physics. During the two years of the project, the fellow will learn all tools and techniques required for completing an analysis in the ATLAS experiment, and more in general for working at LHC. By the end of the Fellowship will be an independent and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nature-inspired smart Information Systems' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

NiSIS overall mission aims:- to co-ordinate multi-disciplinary studies and research endeavours into the development and utilisation of intelligent paradigms in advanced information systems design.- to extend investigations into emerging new areas inspired by nature, both at biological (ie.micro) and behavioural (ie. macro) levels for visionary concepts of information processing and architectures.The project will comprise four parts aiming to interconnect different disciplines and activities in an effective scheme:- The core of the project is a set of three Focus Groups which are to deliver the scientific and technological contributions of the programme. There are Focus Groups on: Nature-inspired Data Technology, Nature-inspired Networks, and Nature-inspired Systems Modelling, Optimisation and Control.- Technology Transfer will take results from the 3 Focus Groups in terms of technological concepts and algorithms, but also contribute challenges via Competitive Workshops concentrating on benchmarking situations taken from real-life relating to IST situations. Training and Education will give added-value in terms of cross-disciplinary instruction and motivation etc. for an upcoming generation of young researchers.- The overall integration of the Project will be overseen by an ITB (Integrated Technology Board), with participants from all of the above groups and committees, thus providing both 'pulling' technology from the life sciences and 'driving' the technology into IST via technical co-ordination of the project and a comprehensively designed Roadmap.- The co-ordination of NiSIS will be achieved via the management component provided by the ELITE Foundation.Apart from the overall co-ordination, assessment of the Project and project activities supervision, the Co-ordinator
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Vulnerability assessment of shrubland ecosystems in europe under climatic changes (VULCAN)'.

assistant: **Innovation**

European shrub land ecosystems are vulnerable to various environmental stress factors. Climate change will lead to higher nighttime temperature, more vigorous rainstorms and extended droughts which will likely have impacts on ecosystem functioning in European shrub lands. VULCAN investigates the these impacts by experimental manipulations of 6 shrub land ecosystems in Europe and studies of the effects of warming and drought on plant, soil, fauna and soil water processes. Temperature manipulations are done as nighttime warming and drought as 2-month summer drought. Based on the experimental results and existing knowledge on management impacts on shrub land ecosystems an expert system is developed to conduct vulnerability scenarios for shrub lands in order to evaluate and prioritise management actions. The results are further integrated with experiences from potential end users through an end user panel and management guidelines to counteract climate change effects on shrub lands are developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A NON-INVASIVE, ADAPTIVE DIGITAL THERAPEUTIC SOLUTION FOR POST-TRAUMATIC STRESS DISORDER AND OTHER MENTAL DISORDERS' (2021-2027).

assistant: **Innovation**

Post-traumatic stress disorder (PTSD) is a severe mental disorder, annually affecting 3.2% of the population with global market-size estimated at 7.5B. Current treatments success is marginal, costly, with severe side-effects. GrayMatters is the first to introduce a non-invasive        digital-therapeutics device harnessing brain plasticity to help PTSD patients control abnormal brain-region activity. Our patented innovation uses machine-learning to convert EEG signal to an fMRI-like signal of the amygdala such that patients learn to self-control their amygdala activity        level using affordable EEG-Neurofeedback device. Initial clinical-trials on stress-resilience & PTSD patients showed significant positive clinical results. The founders have 25+ years experience in commercialization, healthcare & technology with several startups exits/IPOs. LOIs        includes top mental-institutes and world-renowned KOLs of PTSD psychiatry. GMH was recently chosen as 1 of 8 innovative companies by Nature magazine.


**Keywords:** PTSD,amygdala,Post-Traumatic Stress Disorder,mental disorder,digital-therapeutics device