RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Singularidades de ecuaciones diferenciales y foliaciones. Singularites d'equations differentielles et feuilletages'.

assistant: **Innovation**

The proposal is the natural continuation of an existing network in the HCM program. The general scientific objectif are singularities of foliations, researchers. The teams in the network produce each year around ten Ph.D. dynamical systems or more general differential equations over the real or each of them gets easily a permanent position. The total amount of the budget directly devoted to the training of young people is around 1/3 of complex numbers. There are three main lines of work: reduction of singularities, differential Galois theory and geometry of the the total requested financement. The external (inside Europe) relations, as well as the amount of young researchers involved in the network, singularities. guarantees the existence of young researchers to be trained. The main tools we use are deformations, singular perturbations, group actions as group of diffeomorphisms, local algebra, cohomological methods, differential algebra and asymptotic developments. The proposed network is composed by seven teams with a big amount of previous scientifical connections and work in common on the proposed objectives. Many of the basic results in that directions come from join works of team's members.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainable Manufacturing through Advanced Robotics Training in Europe' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposed training network will prepare the next generation of leading Advanced Roboticists to secure a Sustainable Manufacturing (SMART-E) sector in Europe.  It will train 13 Early Stage Researchers (ESRs)  and 1 Experienced Researcher (ER) and develop a leading European doctoral training programme, sustainable beyond the network’s duration. The SMART-E combines state-of-the-art techniques and utilizes innovative technologies in new or lesser known areas involving a team consisting of experts in Embodied intelligence (UZH), Soft Robotics (UZH, SSSA), Compliant Robotics (IIT, USAL) Smart materials (IIT), Safety and Human machine interaction (TUM and FESTO), logistics robotics experts (USAL), and a leading manufacturers and automation in aerospace and food R&D companies (Airbus, FESTO). The team is supported by a number of additional leading Universities, research laboratories and industries as Associated partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Strategic policy intelligence tools for better science and technology investment strategies in Europe's regions'.

assistant: **Objectives**

The RegStrat project is based on an ambitious integrating approach harnessing synergies from various knowledge stocks regarding strategic policy intelligence (SPI) tools, at different governance levels, in different policy and policy research fields, and i n different actor communities of Europe's regional, national and sectoral innovation systems. Our main objective is to bring together, from research and practice, the dispersed knowledge regarding e.g. Foresight, Technology Assessment, Evaluation, Regional Innovation Audits, to develop  ) a Compendium for a SPI tool set, adaptable for diverse regional contexts, and, to facilitate its adoption,  2) Guidelines enabling regional actors (in the private and public arena) to make widespread use of the Compendium to achieve the following impacts - improved focusing, effectiveness, efficiency and alignment of regional RTD 'policies' - higher mobilisation of investments for their implementation.  3) 3 pilot applications to test the concept in the 3 Objective-1 regions plus 3 validation events in the other regions,  4) policy recommendations and dissemination actions to ensure multiplier effects beyond project scope and timeframe.  As a stimulation of regional contributions to the Barcelona 3 % goal, RegStrat has been de signed to generate positive impacts on - increasing regional RTD investments, with a special view to the use of Structural Funds, i.e. through its impacts on - regional RTD governance and regional strategic knowledge base, - interregional co-ordination and co-operation, and their interaction and complementarities with EU and national levels. To optimise outcomes, the Consortium Members have been chosen with a view to working relationships already proven successful, and to adding European value with their comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Swap' under Fifth Framework.

assistant: **Concept**

The conference, organised by the Marie Curie Fellowship Association, in cooperation with the University of East Anglia and ETNET 21 Environment-Water, will focus on how science can contribute to policy, along the lines of the water framework directive, i.e. all aspects of water management from groundwater to surface water, from freshwater ecosystems to estuaries and coastal waters. It will bring together young scientists from all disciplines to interact with senior scientists and present their work on water research, with the objective of (i) training them to expose their approaches to scientists from other disciplines and (ii) encouraging them to think about the policy consequences of their research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'GlucoBeam: A portable device for pain-free glucose self-monitoring in diabetic patients' under Horizon 2020.

assistant: **Concept**

Diabetes mellitus (DM) is one of the largest health challenges currently faced by modern society, affecting 382 million people in the world. DM cannot be cured, but via well-controlled therapy, a high quality of life with diabetes can be obtained, with a minimum of short- and long-term complications. The key to a successful diabetes therapy is a well-controlled blood glucose level, which is obtained by carefully balancing insulin intake, diet, and exercise and with Self-Monitoring of Blood Glucose (SMBG) as a cornerstone. Conventional SMBG is an invasive test requiring the patient to prick his/her finger with a lancet to extract a blood droplet onto a disposable strip for electrochemical analysis of the glucose concentration. Repeating this uncomfortable and painful task 4-8 times per day leads to severe loss in life quality, often resulting in poor compliance leading to costly complications.RSP’s proprietary non-invasive SMBG technology relies on the capabilities of Raman spectroscopy for directly detecting individual substances, refined by a unique critical depth optical scanning to collect glucose signals from the right tissue depth range, thus avoiding sources of errors during the measurement. Our GlucoBeam device will enable DM patients to test their glucose levels in around 30s and as often as desired – at no added cost or pain – thereby empowering them to better manage their treatment and minimizing the risk for acute complications. GlucoBeam’s successful commercialization will position RSP to secure an aggregated turnover of approx. €253 million over the 5 years post-project period. Furthermore, it has the potential to reach double digit billion savings for EU’s healthcare systems and will ultimately lead to significantly improved life quality for the large popu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EPIGENETIC MARKERS OF DISEASE STATUS AND REVERSAL FOR PERSONALIZED MANAGEMENT OF OBESITY AND DIABETES' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Epigenetic marks such as DNA methylation (DNAm) can store cell memories of past life experiences. Thanks to this property, these marks hold great potential as biomarkers for personalized management of diseases arising from gene-environment interactions such as obesity and associated disorders. However, realizing this potential requires large-scale longitudinal studies that evaluate epigenetic markers under consideration of pertinent lifestyle and genetic factors. The goal of the proposed project is to fill this research gap by identifying, for the first time in a large-scale longitudinal study, epigenetic biomarkers of disease status and reversal for personalized management of obesity and diabetes.  To attain this goal I will i) Identify overweight -associated DNAm markers by comparing DNAm patterns of 400 obese subjects before and after a randomized controlled weight-loss intervention, ii) Assess the relationship of the identified markers with gene-diet interactions, and their reversibility in response to weight-loss, iii) Test the validity of these markers, alone and in combination with genetic analysis, as biomarkers for prediction of weight-loss performance and diabetes status/reversal. Expected outcomes: I) Drive innovation in personalized medicine by identifying epigenetic markers of disease status and reversal in obesity and diabetes, ii) Expand our understanding of how epigenetic, genetic and dietary factors interact with each other in the development and reversal of obesity, iii) Equip me with the knowledge and skills needed to become an independent scientist. The quality of the research, hosting arrangements and collaborations will provide me with the best opportunities to expand my expertise in epigenetics, apply it to research on human disease, and reinforce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MultiScale phenomena in Radiation Damage' (MS-RADAM).

assistant: **Innovation**

The MS-RADAM DN will deliver a state-of-the-art research programme that will pioneer a new approach to reveal key nano- and larger-scale radiation biodamage phenomena based on multiscale modelling (MM) and its thorough validation using advanced experimental techniques and technological applications. In particular, the MS-RADAM research programme will focus on obtaining an advanced understanding of Radiation Damage (RADAM) phenomena induced by ion irradiation in biomolecular and biological systems relevant to the application of this knowledge in particle therapy and many other relevant areas of research and technology.The unique feature of the MS-RADAM research programme is the MM description and measurement of key processes and phenomena occurring on different temporal and spatial scales during ion-beam irradiation incorporating: (i) propagation of charged particles in biological media, (ii) radiation-induced fast quantum processes within biomolecular environments, (iii) characterisation of the time and spatial evolution of track structures and localised energy deposition, (iv) slower nanoscale post-irradiation relaxation, chemical and thermalisation processes occurring in the irradiated biological media, (v) evaluation of biodamage accounting for specific radiobiological effects. To initiate such a programme and to provide industry, radiotherapy research community and many other related communities with a cohort of skilled researchers, MS-RADAM DN will train 14 Doctoral Candidates (DCs) in the methodology and skills needed for this emerging area of research and technology.MS-RADAM DN contains leading academic and industrial partners with the necessary experience to provide the international, interdisciplinary and intersectoral training needed for the MS-RADAM research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Milky Way as key to understanding the inward transport of matter to the centre of galaxies' under Horizon Europe.

assistant: **Concept**

Gas accreting onto supermassive black holes that sit at the centres of galaxies fuels the most powerful engines in the universe, Active Galactic Nuclei, shaping the formation and evolution of their host galaxies. Yet, we have a poor understanding of how the gas is transported from typical galactic radii, R=several kpc, down to the area of influence of the black holes, less than a few pc. The centre of the Milky Way can be studied in much greater detail than any other galactic nucleus and is a Rosetta Stone to understand the physical processes that occur in all galaxies. Interstellar gas is transported from the Galactic Disc down to the central black hole SgrA* through a sequence of steps. The Galactic Bar performs the first step by efficiently transporting gas from the Disc (R=3kpc) down to the ring-like accumulation of gas known as the Central Molecular Zone (CMZ) at R=120pc. In the last few years I have led major theoretical efforts to understand and quantify this first step. However, these efforts have also demonstrated that the bar is ineffective in driving the gas further inwards. A long-standing question is how the gas continues from the CMZ to SgrA*. For the first time we have the possibility to answer this question thanks to new datasets and advances in numerical simulations. I propose here an unprecedented effort to solve this important problem through a unified analysis of all the relevant physical processes based on novel data and methodologies. I will combine recent and upcoming high-resolution astrometric and spectroscopic data with advanced stellar dynamical models to constrain the gravitational potential in the Galactic centre (GC). I will then use this potential to run cutting-edge numerical simulations to systematically quantify the contribution of all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring and Modifying the Sense of Time in Virtual Environments' to be submitted under Horizon 2020.

assistant: **Abstract**

The sense of time co-constitutes our subjective experience and embodied self-consciousness. It refers to the dimensions of passage of time (time passing by) and structure of time (serial order of events). Both can be disturbed under psychopathological conditions and give rise to a variety of psychopathological symptoms. VIRTUALTIMES will for the first time (1) provide a personalized and neuroadaptive virtual reality technol-ogy enabling the systematic variation of time experience (“MetaChron”), based on (2) the rigorous study of the sense of time in different psychopathological conditions including depression, schizophrenia and autism, under special consideration of sex, and (3) neuroscientific measures that describe neural mechanisms which underlie our sense of time and validate both diagnostic differences and technological interventions. For that purpose, virtual reality scenarios and games will be developed from the starting point of the everyday sce-nario “waiting room”. We will systematically enrich the scenery both physically (objects) and socially (inter-action partners). In the realm of time-based interventions this will allow to manipulate passage of time (vary-ing velocity of time flow) and structure of time (varying synchronicity of events). VIRTUALTIMES (1) will provide “MetaChron” as diagnostic tool and innovative mental health technology that works in a highly in-dividualized, easy-access, and easy-to-use application, (2) will foster new technological developments in the field of human-computer-interaction to improve personal wellbeing and intercultural communication in a global world, and (3) will initiate a radical shift both in empirical approaches to and our understanding of the sense of time as basic constituent of human subjectivity. The market value
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Decoding molecular sexual dimorphism of neuromuscular function'.

assistant: **Innovation**

Motor functions implement evolutionary relevant and necessary actions, such as running and breathing. They rely on electric impulses which produce muscle contractions through the neuromuscular junction (NMJ). Sex-dependent features including hormone production and genetics influence neuromuscular pathophysiology, but the molecular players involved are unknown.Here, I will unravel how sex hormones shape and maintain NMJs by dissecting the unconventional signalling exerted by peripheral hormone receptors. Indeed, unexpectedly, androgen receptor (AR) localizes at the neuron periphery and is regulated by neuronal activity. Trinucleotide repeat expansions (TRE) in AR gene cause spinal and bulbar muscular atrophy (SBMA), a neuromuscular disease caused by motor neuron degeneration and muscle wasting. As AR interacts with components of the translation machinery and RNA-binding proteins, I hypothesize that extra-nuclear AR is a regulator of NMJ stability mediated by hormone binding, regulating sex-specific local translation of key mRNA targets in a phosphorylation/dephosphorylation-dependent manner, mechanisms which fail to support neuron/muscle crosstalk in SBMA.Applying sophisticated in vitro models such as cocultures in microfluidic devices and cutting-edge spatial technologies, I propose to test this by: 1. Dissecting the in vivo NMJ transcriptome in healthy males/females and SBMA mice using unbiased Nova-ST technology and snRNA-seq.2. Elucidating the sex-specific synaptic translation events in motor axons and NMJs using ribosome sequencing from microdissected subcellular compartments.3. Identifying the molecular players involved in the AR-dependent local translation at the NMJ and their dysregulation in disease using proximity labelling. AR-NMJ will be the first of its kind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sustainable Catalytic C-H Bond Functionalization' (CatCHFun), addressing dissemination and exploitation.

assistant: **Impact**

The impressive progress in synthetic organic chemistry during the past century has propelled this discipline to its current central place as the key enabling technology in the physical and life sciences. Despite these remarkable advances, our ability to construct molecules of even moderate structural complexity remains unsatisfactory, since these syntheses continue to be inefficient, rely on a high number of reaction steps, and generate undesired, often toxic waste. These features led to the general need for greener transformations that will stimulate the development of more sustainable chemical industries.Conventional approaches in synthetic organic chemistry make use of starting materials displaying specific functional groups, the installation of which results in costly reaction and purification steps. Therefore, an environmentally-sound and economically-attractive alternative is represented by the direct functionalization of ubiquitous carbon-hydrogen (C–H) bonds. These transition-metal-catalyzed processes avoid prefunctionalization strategies, prevent the formation of undesired waste, and thus enable an overall streamlining of organic synthesis.While considerable recent progress has been accomplished in C–H bond functionalizations, available methodologies continue to be limited in scope, and key challenges are still to be overcome. Establishing a full set of sustainable C–H bond functionalization protocols will undeniably have a tremendous impact on various applied areas, such as drug discovery, chemical industries or material sciences.