RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hanover experimental lung research project' (XHaLe), addressing dissemination and exploitation.

assistant: **Impact**

Non-neoplastic lung diseases (NNLD), such as COPD and interstitial lung diseases rank second among the causes of death and NNLD appear as a growing EU wide challenge. They are characterized by irreversible remodeling with a relentless loss of lung function and a 5-year survival of only 30%. This dysfunctional reaction to injury can be triggered by particulate matters with macrophages (MO) as the key regulators. Wholesale therapeutic suppression of the inflammome actually increases the risk of death, whereas targeted therapy of signalling cascades by novel pharmaceuticals, e.g. nintedanib, only slows disease progression. Thus lung transplantation remains the ultima ratio. However, available grafts are limited, treatment costs are high and the 5-year survival barely surpasses 50%. Therefore novel approaches to understand, prevent and ultimately cure NNLDs are urgently needed. Towards this goal my group focusses on both, the main effector cell in NNLD, the myofibroblast, and the inflammome and particularly MOs, as these orchestrate both, lung healing and remodeling. Modulating the pulmonary immune system, rather than subduing it, holds significant promise. To this end, we have to understand the very early events in NNLDs. There are 2 major obstacles for efficient research: i) the lack of adequate animal models and ii) the availability of human specimens. Therefore we established a unique platform for NNLD: we utilize fresh explanted human lungs from Europe’s largest LuTx program and set up a singular 24h/7d workflow, ensuring short ischemia and tissue viability. In the last years, we have worked up over 500 lungs, acted as an international multiplier for pulmonary research, patented new imaging techniques and described novel diseases. Our understanding MO biology in NNLDs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantum optics in nanostructures' (OPTNANO), addressing dissemination and exploitation.

assistant: **Impact**

Nanomaterials are intriguing structures for quantum optics. Their color depends on their size and shape; they are very selective in the wavelengths they absorb and emit. Although nanostructures have been used to color windows and surfaces since the Middle Ages, we lack the understanding how size, shape, and microscopic structure control the optical properties of nanomaterials. In this project, we plan to develop a fundamental description of quantum optics in one-dimensional nanosystems. Core concepts will be quantum confinement and electron interactions when carriers are forced into a small space. The proposed work will focus on carbon nanotubes as a model nanosystem. The tubes show pronounced confinement effects; they emit and absorb light in the near infrared and visible. We will measure optical transitions, quantum cross sections, and electron interaction using luminescence, Raman scattering, and photoconductivity. The optical properties will be tailored by selecting specific tube types and changing the tube environment. A description of optical processes is incomplete without considering defects in real nanostructures. We will develop techniques to study and introduce imperfections. Their optical signatures and their effect on light emission will be determined on individual tubes. The experiments will be complemented by materials modeling. We will describe confinement effects and Coulomb interaction in semiempirical calculations of nanotube light absorption. The knowledge gained on carbon nanotubes will be applied to predict and study the optical properties of other one-dimensional systems. The goal is to obtain a robust and transferable model of quantum optics in nanostructures. This project will also advance characterization of nanomaterials by optical spectroscop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ARTIFICIAL INTELLIGENCE BASED HEALTH, OPTIMISM, PURPOSE, AND ENDURANCE IN PALLIATIVE CARE FOR DEMENTIA', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Dementia is caused by a range of illnesses and disorders that damage the brain either directly or indirectly. With the rise of the ageing population in the EU, dementia is becoming a serious problem. Digital health interventions have the potential to improve the accessibility and effectiveness of palliative care. Palliative care is an area where these technologies are increasingly being evaluated for education (e.g. online learning, mobile applications or Virtual Reality tools), symptom management, care planning, decision-making, and interaction (e.g. professionals and caregivers using phones, internet and computer systems). However, most studies focus on a specific intervention with heterogeneous outcomes and are exposed to professional gatekeeping and biased samples consisting of patients who are mostly well and without considering cultural impacts. Due to improved understanding and treatment, more effective and innovative health technologies, improved patient safety and better ability and preparedness to manage epidemic outbreaks, along with priorities related to quality of life of dementia patients and survivors, treatment and dementia data monitoring should be crucial. This project will focus on: i) better understanding of dementia, focusing on their consequences, including pain, distress and causative links between health determinants, disease and interventions in order to provide evidence-base for policy-making, ii) identification of holistic intervention (treatment and care) and assessment of health outcomes, iii) innovative digital tools to optimize clinical workflows and iv) scientific evidence for improved/tailored policies and legal frameworks and to inform major policy initiatives at EU and global level. We target exactly those aspects of value by integrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Targeting auto-reactive B-cells by vaccination to cure human auto-immune disease'.

assistant: **Concept**

Currently, most human autoimmune diseases are chronic conditions without a prospect of cure. My aim in this proposal is to meet the next major challenge, achieving cure in autoimmune disease.Many autoimmune diseases are characterized by autoantibodies and are remarkably responsive to B-cell targeted therapies, demonstrating that the autoreactive B-cell is central to disease pathogenesis. Nonetheless, the selective and permanent elimination of the autoreactive B-cell, both memory and plasma cells alike, is not presently feasible due to a lack of specific markers and treatments. My aim is to develop a vaccine that will allow the specific and long-lasting depletion of autoreactive B-cells, thereby inducing cure. Using the unique mutated sequences of autoreactive B-cell receptors (BCR), cytotoxic T-cells that specifically eradicate autoreactive B-cells will be induced. This concept extends the remit of vaccines beyond infectious diseases and cancer, into the sphere of autoimmune disease.Using the well-defined autoimmune disease rheumatoid arthritis (RA) as prototype, I will study the RA-specific autoimmune response. Our recent findings show that RA is characterized by a restricted, oligoclonally-expanded autoreactive B-cell pool. Using recently developed technologies, my team will identify autoreactive B-cells and the BCR repertoire at several (pre)disease stages. We will then determine the potency of the many non-germline-encoded mutations in BCRs as neoantigens amenable to T-cell recognition and vaccination. Incorporating these neoantigens into multiple long peptides covering the autoreactive B-cell repertoire, we will design patient-tailored vaccines and perform a phase I trial to determine the feasibility of specifically depleting disease-causing B-cells.This research w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functional characterization of specialized metabolites from gut microbiomes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Composition changes of the human gut microbiome has been associated with a series of diseases. However, little is known about the mechanism of this microbiome alteration. Recent in silico studies revealed thousands of biosynthetic gene clusters (BGCs) that encode diverse types of specialized metabolites from human microbiomes. Many of these molecules are potentially involved in shaping microbiome structure or directly affect host cell and contribute to disease development. To date, only colibactin, a hybrid polyketide/non-ribosomal peptide produced by Escherichia coli in human gut, has been experimentally validated for its deleterious metabolic impact on human host and linked to the development of colorectal cancer (CRC). Thus, this project aims to expand the knowledge of specialized metabolites produced by gut microbiome and unravel their role in development of inflammatory bowel disease (IBD) and CRC. State-of-the-art bioinformatic, synthetic biology and chemical-analytic technologies will be used to tackle this challenge. In silico identification of BGCs will be facilitated by sequence homology search and the occurrence of function-related resistant makers. The cloning process will be realized by either capturing native BGCs, adopting polymerase amplification or using synthetic DNA, followed by HiFi DNA assembly, Red/ET recombineering based DNA integration method or combining of both strategies. The chemical diversity of these specialized metabolites will be unlocked by heterologous expression of the cloned BGCs and structure elucidation of the produced molecules. The biological functions of the discovered compounds will be established by probing their genotoxicity and cytotoxicity in vitro with human intestinal cell lines.


**Keywords:** gut microbiome, biosyntheti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Determination of Plaice lifetime movements in the North Sea by linking natural and electronic data records'.

assistant: **Objectives**

We aim to describe the lifetime movements of plaice, Pleuronectes plates, in the North Sea, by linking the geographical movements of fish tagged with electronic data storage tags (Dusts) to chemical signals simultaneously laid down in the ear-stones (eoliths) of the same fish. By linking these state of the art techniques, we aim to provide information on the population dynamics of North Sea plaice, which would be otherwise unattainable using conventional methods. Dusts allow continuous records to be made of ambient conditions experienced by free-swimming fish in their natural environment. To date, we have used tidal (depth) data to reconstruct the migrations of 165 plaice from returned Dusts, for periods of up to 512 days. Plaice independently record ambient conditions throughout their lifetime by the accretion of various chemicals on the eolith. Matching the recorded migrations with the chemical signals from the eolith may allow the retrospective positioning of the fish in space & time throughout its life. We will examine the eoliths from around 80 DST-tagged plaice, using stable isotope analysis to characterise annual migration routes. This process should for the first time allow interpretation of the migration history of the plaice prior to tagging & determination of the time and source of recruitment, thereby linking studies of pre- and post recruitment fish behaviour. By implementing this work as an intra-European fellowship, we are providing the opportunity for a researcher with a proven track record in ecology, otolithology and stable isotope analysis, to refine and develop existing techniques & to advance to the forefront of the field. The results of this study have the potential to improve the parameterisation of assessment methods currently applied in fisherie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Self-organising MESH Networking with Heterogeneous Wireless Access' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Wireless mesh networking is being considered as a promising solution for scalable and ubiquitous Internet access for one decade already. Still, major limitations remain to be overcome before the concept matures to fulfil the promise. What’s more, the potential of integrating the mesh networking paradigm in the context of heterogeneous technologies has not been yet sufficiently explored. Pursuing advancement along these lines, towards shaping next generation mesh networking, calls for cutting-edge research and development (R&D) efforts with inter-sector knowledge renewal and integration.The MESH-WISE project responds to these needs by mobilising a joint academic-industry task force on two complementary themes. First is the development of novel mechanisms for deployment and resource allocation of self-organising mesh networks. The second theme comprises the investigation of multi-purpose and heterogeneous mesh networking and its emerging applications such as traffic offloading, emergency deployment and provisioning, and sensor integration.Designing future wireless mesh systems based on heterogeneous radio technologies with self-organising capabilities necessitates original R&D actions. The MESH-WISE project takes a holistic view in developing models, protocols, and algorithms in a wide spectrum, from theoretical analysis to proof-of-concept and prototyping. Towards these ends, the MESH-WISE project follows the approach of intensive inter-sectorial exchange of knowledge and know-how between the consortium partners.In addition to R&D, MESH-WISE contributes to competitiveness development by training researchers. The knowledge transfer programme is designed on a mutual-benefit basis between the academic and industrial partners, to promote new career opportunities and developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates' (EHVA) under Horizon 2020.

assistant: **Objectives**

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of window and door profile systems made from grp, manufactured in the pultrusion method' in the context of a Fourth Framework call.

assistant: **Objectives**

Pultrusion opens possibilities for window and door profiles. Up till now, only relatively simple shaped products could be manufactured. Now technical methods are being developed which make it possible to pultrude more complicated profiles. In addition, the static values can match those of aluminium profiles With the axial reinforcement,better results can be expected. The aim of this research is to develop Glassfiber Reinforced Products (GRP) for window and door profiles that reach a K-value of 1-1,2 W/m2°K. Additional research has to prove that these profiles are in agreement with the European regulations concerning environment, safety, noise reduction and aesthetics. The right type of resin has to be developed including the facility of using standard hardware and accessories. Research has to be done in designing and testing the prototypes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Storming Immune Monogenic Conditions through Multiomic and Gene Editing Approaches' (IMMERGE) targeting Horizon Europe.

assistant: **Abstract**

The human immune system controls the efficiency to respond to infections and eliminate aberrant cells, such as cancer cells. Immune function depends on the balanced contribution of many genes, encoding for receptors, cytokines, cell signalling molecules and transcription factors and are modulated by a wide range of environmental and epigenetic factors. Monogenic mutations for immune-related genes, also known as Inborn Errors of Immunity (IEI), provide unique examples for understanding immune fitness. IEI, individually considered as rare diseases, constitute a group of >400 immune disorders with a combined prevalence similar to leukemias (1/1,000-1/5,000). For a given mutated gene, IEI patients can display a wide range of phenotypic expressivity (from asymptomatic to severely impaired) and different responses to treatments. Therefore, there is an unmet need to address the wide underlying impact of IEI. Previous EU consortia have not addressed these questions in full. It is therefore needed a new generation of researchers, equipped with a complete set of scientific, technological and strategic skills; and a wide vision to face the outstanding challenges in the IEI field. To this end, the IMMERGE MSCA DN combines the talent of leaders from different clinical and basic research and biotech environments to train 11 doctoral candidates. Through our research activity and training activities, we will address key challenges in the field: 1) To assess the functional impact of IEI in different immune cell types through single cell and bulk multiomics. 2) To develop computational tools for dissecting the altered cellular pathways underlying specific IEI. 3) To genetically correct or model IEI and develop pre-clinical models. With our strategy, IMMERGE will generate an outstanding n