RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Factors affecting hide and skin quality : development of strategies for improving the raw material of the leather industry' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

General Objectives and Relevance to the work programme objectives Hides and skins account for about 10% of the value of an animal and are potentially important in the generation of cash income for producers. The proposed project will establish a network linking those engaged in research into raw material quality (at the farm, abattoir or hide market), with those engaged in related work for the leather industry. It will also prioritise the need for further research on these factors based on an economic analysis of the potential increase in returns resulting from improved control. This will improve the focus of the work already ongoing in the different institutes represented in the consortium and enhance its relevance to the livestock producers. The general or long-term objective of the concerted action is the improvement in the quality of the hides and skins available to the leather industry. This will be achieved by identifying the priorities for further research and exploiting the collective potential of ongoing research activities of the European Union. The exchange of information and research materials is a key issue in the success of this project. Specific Measurable Objectives Within this project there are 3 key objectives:a. To form a network of prominent researchers from all areas of hide and skin production. b. From this network, research efforts within the consortium will be co-ordinated to enable studies to be complimentary. c. A working document outlining the needs of the industries throughout the hide and skin supply chain is required and this will be prepared during the programme. From these general targets several specific objectives can be detailed as follows: 1. The establishment of a sustainable network involving European Union partners. 2. Increased aw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The unity of scattering amplitudes: gauge theory, gravity, strings and number theory' (UNISCAMP).

assistant: **Innovation**

Scattering amplitudes are central observables in quantum field theory and provide essential information about the quantum consistency of perturbative gravity. Precise control of the physical and mathematical properties of scattering amplitudes holds the key to long-standing questions on fundamental interactions and the structure of space and time. As a concrete leap in this direction, UNISCAMP addresses predictions in gauge theories, gravity and effective theories through- the efficient computation and compact representation of scattering amplitudes and,- decoding their hidden structures & symmetries and their rich web of connections.String-theory methods will complement conventional approaches to scattering amplitudes, and I will combine the insights from- the point-particle limit of superstrings & heterotic strings and,- the recent ambitwistor strings which directly compute field-theory amplitudes.Both of them naturally incorporate the double-copy relation between gauge-theory & gravity amplitudes and extend the framework to effective field theories describing pions and other low-energy states. It is a primary goal of UNISCAMP to pinpoint the unifying principles connecting a wide range of field and string theories. My expertise in both flavours of string theories will allow to optimally exploit their fruitful synergies and to depart from mainstream approaches. Moreover, field- and string-theory amplitudes exhibit an intriguing mathematical structure: Their Feynman- and moduli-space integrals yield special functions such as polylogarithms which became a vibrant common theme of high-energy physics and number theory. As an interdisciplinary goal of UNISCAMP, I will- investigate the low-energy expansion of multiloop string amplitudes and,- extract an organizing scheme for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Theater in Imperial Spain: studying a commercial activity during the first globalization from the perspective of labor and economic history' (THIS).

assistant: **Innovation**

The overall objective of this project is to study the Hispanic theater professionalization process during the second half of the 16th century and the early decades of the 17th century from the perspective of labor and economic history. Furthermore, I approach this process in light of the first globalization, that is considering both Spain and its overseas colonies, as well as the interconnections between them. This is imperative because Golden Age professional theater has been and continues to be subject of many studies, especially philological, but we have not fully understood the basis of the functioning of this new profession that emerged in the mid-sixteenth century; the reason is clear: we are dealing with a commercial activity that has not been specifically and systematically studied as such, since, to do so, it is necessary to understand its economic and labor dynamics. In addition, professional theater has not been studied as a global phenomenon and this is also a serious problem because in the sixteenth century imperial Spain expanded into America and this fact cannot be ignored, much less if we are talking about a profession that developed almost at the same time on both sides of the ocean. The project has four phases. In the first one, a database will be created to collect and organize theatrical economic information; the database is intended to become an open-access tool. During the other three phases of the project, labor and economic history methodologies will be implemented to reconstruct cases of theatrical enterprises, to analyze the labor and economic conditions of different types of comedians and, finally, to calculate approximately the costs of staging a play at the end of the sixteenth century. Thus, this project would introduce new methodologies to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Temporal Genomics for tailored chronotherapeutics' under Sixth Framework.

assistant: **Concept**

Chronic diseases account for 75% of the disability-adjusted years in Europe and cause the premature death of 17 million people worldwide. Differences in aetiology as well as patient genetic origin, gender, age, lifestyle and biological time structure account for large variability in individual time courses of the same disease entity. Patient-tailored therapeutics is needed to prevent adverse events and improve overall therapeutic activity.Rather than using pharmacogenomics for excluding patients from an active treatment option, TEMPO will combine functional genomics, proteomics, cell signalling, systems biology and pharmacokinetics to optimize therapeutic index in most individual patients. Thus TEMPO will determine 3 to 5 chronotherapeutics schedules with distinct temporal delivery patterns of the same anticancer drug. Each schedule is adjusted to a different dynamic class of temporal genomics and phenomics parameters related to interwoven circadian and cell division cycles and drug metabolism. In vivo, in vitro, in silico approaches are integrated through the multidisciplinary excellence in the consortium.TEMPO will offer a proof of principle of tailored chronotherapeutics in mouse models for irinotecan, an active drug against colorectal cancers, and for seliciclib, currently in clinical testing. TEMPO will gather the corresponding human prerequisites and technology for subsequent application to patients. Three SMEs play a pivotal role for the impact of TEMPO on European health, economics and society. Novel and complementary in silico dynamic models of coordinated clock, cell cycle and pharmacology pathways will identify new therapeutic targets and delivery schedules of active molecules, thus improve drug development processes. New tools will enable personalized medici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Changing population of europe: uncertain future'.

assistant: **Innovation**

Forecasts of the age/sex composition of the population in all countries of the European Economic Area (EEA) will be computed up to 2050. The innovative aspect is that forecast uncertainty is quantified: we will compute so-called predictive intervals, which specify the probability that the future population will be between x and y million (and likewise for all age groups, at each year in the future). The traditional approach (applied e.g. by Eurostat and national agencies) is merely to run variant projections, for example assuming high, medium, and low fertility and /or mortality, without attaching probability content to them. In addition to the stochastic forecasts for all EEA-countries at the national level, sub-national stochastic forecasts will be computed for selected EEA-countries with good migration data. Illustrations will be given as to how uncertainty concerning the number of elderly in the future affects social policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Recycling putrescent waste through composting' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The problem to be addressed is the difficulty of dealing safely, economically and in an environmentally friendly way with putrescent waste. A new concept in composting is a possible solution. This would allow a large reduction in the amount of organic waste, which is currently placed in landfill sites or incinerated while satisfying a growing market for fertilizer alternative and other inputs forth-organic food sector. Research on the new composting concept is required to devise the most suitable composting methods, to design the specialist equipment and to specify appropriate management systems. Prototype compost products will be tested and subject to consumer acceptance trials. The anticipated deliverable will be a composting system for putrescent wastes which provides composted products suitable for a defined range of markets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Immune Niches for Cancer ImmunoTherapy Enhancement' under Horizon 2020.

assistant: **Concept**

Cancer is rapidly becoming the most frequent cause of morbidity and mortality in the EU, accounting for a quarter of all deaths in EU. Without breakthroughs in treatment, cancer is likely to remain one of the biggest killers in the 21st century. Immunotherapy of cancer by checkpoint inhibitors, vaccines or adoptive T cell therapy is coming of age and has the potential to cure cancer, but is still hampered by some major limitations. For instance, Adoptive Cell Therapy (ACT) with unmanipulated or engineered T cells (TCR-transgenic and CAR-T cells) has indeed demonstrated success in the treatment of patients affected by leukemias, but is much less effective against lymphomas and solid tumors. One likely explanation is that we do not educate the right type of anti-tumor T cells. The T cells considered to be the gold standard for tumor therapy have stem cell memory features, but the proper and safe way to generate these fit T cells for clinical purposes is still an unresolved matter. Here we propose an advanced transformative technology termed INCITE, utilizing a novel high-resolution 3D microfabrication technology to engineer a specially tailored microenvironment that will be inhabited by cells central for T cells education in order to generate the fittest anti-tumor T cells for advanced adoptive T cell therapy.  INCITE will bring together a transdisciplinary consortium capable of developing this innovative platform by combining state-of-the-art 3D printing, computer modeling, bioengineering, bioinformatics, immunology, developmental and cancer biology approaches, toward the development of a functional immune niche for selection and expansion of tumor-rejecting T cells.  The INCITE platform will revolutionize the treatment of cancer patients with ACT, with a profound impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ecotoxicity of metal nanoparticles in soils' (NANO-ECOTOXICITY), addressing dissemination and exploitation.

assistant: **Impact**

As a consequence of the increasing production of nanomaterials and subsequent release, there is increasing concern about their possible side effects in the environment. Due to their small size, nanoparticles (NPs) are more reactive than related non-nano materials and thus new biological effects may be expected. Metal NPs are being detected in the environment, and observations on uptake and adverse effects in organisms have already been described in the literature. Little data however, exist on the effects of NPs in soil.This study deals with the toxicity of metal NPs to soil-dwelling organisms with the aim of linking their fate and effects in terrestrial ecosystems. The work will be based on case studies with ZnO and Ag NPs, representing different fate kinetics.Toxicity tests will be performed to evaluate the effect of ZnO and Ag NPs on the earthworm Eisenia andrei and the nematode Caenorhabditis elegans, using different soil types (e.g. ranges of properties influencing metal binding capacity) and different ageing conditions. Measurement of toxicokinetics and exposure will help to unravel the main routes of uptake of metal NPs in these organisms. A full characterization of properties, fate and behaviour of metal NPs in soil will be essential to properly link exposure and effects.For that purpose, the training programme will put great emphasis on gaining and expanding knowledge on the fate of metal NPs in soil and uptake in organisms. This will require training in new techniques for detecting and characterizing metal NPs in different matrices, including soil, pore water and biological tissues. Metal speciation modelling will be learned to enable linking NP fate to bioavailability and toxic effects. Training will also include learning new ecotoxicological methods and mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural Engineering of 2D Atomic Planes towards Task-Specific, Freestanding Superstructures through Combined Physical-Chemical Pathway' (CHEPHYTSSU).

assistant: **Innovation**

The research on 2D nanomaterials has boomed since the discovery of graphene by professors Geim and Novoselov in 2004. After a decade of steady development, the available library of 2D crystals is highly rich including graphene derivatives, hexagonal boron nitride, many chalcogenides and various oxides. However, the technological advances and urgent environmental and sustainable energy issues such as CO2 capture and separation, energy storage and conversion (photovoltatic system, supercapacitor etc) call for advanced materials with not only properties of individual layers but also new functionalities. Particularly, researches on superstructures with unique properties such as amphiphilicity still remain blank. Physically, it is now possible to create such hybrid superstructures by placing different 2D crystals on top of each other in a designed sequence; while engineering the 2D units through a chemical way endows a high flexibility in surface chemistry tailoring and increase the mechanical stability due to the strongly bonded interface. Taking these into consideration, here we propose a combined chemical-physical pathway to engineer task-specific, mechanically freestanding superstructures based on 2D atomic planes in a simple and scalable manner. Three new material concepts are proposed including amphiphilic superstructure (hydrophilic outer layer and hydrophobic inner layer), gas selective superstructure (CO2-phililc outer layer and gas shape selective inner layer) and flexible superstructure with outer layer functionalized with metal oxide nanoparticles confined in ordered mesopores and inner conductive graphene. The obtained superstructures with these structural features will be oriented environmental and sustainable energy issues such as CO2 capture and separation, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unravelling the evolution of antiviral sensors and response systems in animals using the phylum Cnidaria' under Horizon 2020.

assistant: **Concept**

Viruses are absolute parasites as their replication depends on biochemical systems of their host. Because viral infections reduce the fitness of the host organism, hosts and viruses have been tangled in an evolutionary arms race for survival from the very beginning of life. As the immune system allows organisms to identify and eliminate viral infections, it is of pivotal importance for host fitness. In vertebrates, the antiviral immunity is heavily based on the interferon pathway that enables infected cells to alert neighbouring cells against incoming infection and recruits cells of the immune system to battle the virus. However, in the case of invertebrates, which lack interferons, the antiviral immunity is believed to be based mostly on an RNA interference (RNAi) that cleaves viral RNA. Until now, the recognition mechanism and mode of action of such systems were studied mostly in vertebrates, insects and nematodes. From this limited phyletic sampling, it is impossible to deduce what was the original mode of action of these systems in their last common ancestor and how antiviral immunity was triggered in early animals. To attain novel insights into the early evolution of this crucial system, I propose to study it in an outgroup: the sea anemone Nematostella vectensis, a representative model species of Cnidaria, a phylum that diverged approximately 600 million years ago from the rest of animals. Beyond its key phyletic position, Nematostella is a tractable lab model with available advanced molecular and gene manipulation tools making it an excellent comparative model. I will harness these tools to decipher the cnidarian system for battling RNA viruses and answer the outstanding questions regarding the evolution of antiviral immunity and its ancestral state in animals. M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AUTOMATION AND INCOME DISTRIBUTION: A QUANTITATIVE ASSESSMENT' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Since the invention of the spinning frame, automation has been one of the drivers of economic growth. Yet, workers, economist or the general public have been concerned that automation may destroy jobs or create inequality. This concern is particularly prevalent today with the sustained rise in economic inequality and fast technological progress in IT, robotics or self-driving cars. The empirical literature has showed the impact of automation on income distribution. Yet, the level of wages itself should also affect the incentives to undertake automation innovations. Understanding this feedback is key to assess the long-term effect of policies. My project aims to provide the first quantitative account of the two-way relationship between automation and the income distribution.It is articulated around three parts. First, I will use patent data to study empirically the causal effect of wages on automation innovations. To do so, I will build firm-level variation in the wages of the customers of innovating firms by exploiting variations in firms’ exposure to international markets. Second, I will study empirically the causal effect of automation innovations on wages. There, I will focus on local labour market and use the patent data to build exogenous variations in local knowledge. Third, I will calibrate an endogenous growth model with firm dynamics and automation using Danish firm-level data. The model will replicate stylized facts on the labour share distribution across firms. It will be used to compute the contribution of automation to economic growth or the decline of the labour share. Moreover, as a whole, the project will use two different methods (regression analysis and calibrated model) and two different types of data, to answer questions of crucial policy importance