RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breaking the membranous refuge of intracellular bacteria' (INCLUSION-INTEGRITY).

assistant: **Innovation**

Many clinically important pathogens invade human cells and evade their intrinsic defenses by hiding within pathogen-containing vacuoles (PCVs). Hence, it may be feasible to combat such microbes by deliberately destabilizing their PCVs. To promote progress towards such an innovative therapeutic concept, I propose a 5-year research program in which my team will generate a molecular mechanistic understanding of how the PCV is maintained, how it can be destabilized, and how the consequences of PCV destabilization can be steered towards a beneficial outcome. We will focus on the inclusion, i.e., the PCV of Chlamydia trachomatis, as the strong host cell dependence of this leading bacterial cause of ocular and urogenital infections makes it an exquisite target for pioneering PCV-destabilizing strategies. In AIM 1, we will leverage inclusion-destabilizing conditions we identified previously and state-of-the-art proteomic, lipidomic, and microscopic approaches to address the fundamental question of what distinguishes unstable from stable inclusions. In AIM 2, we will build on these findings and apply our unique microscopic reporters for inclusion damage and a robust genetic approach to identify the molecular basis of inclusion stability, determine how distinct forms of inclusion destabilization interact with each other and with host cellular defense programs, and find ways to steer the outcome towards either host cell death or survival. Finally, in AIM 3, we will clarify which of those two outcomes therapeutic targeting should aim for by isolating cells cured from infection via inclusion destabilization, followed by systematic cell biological and omics investigations to determine if infection causes long-lasting damage to host cells. By filling critical knowledge gaps in the fie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Internal exposure – in tissue equilibrium sampling to bridge the missing link between bioavailability and bioaccumulation'.

assistant: **Concept**

The training program is designed for Annika Jahnke, a very talented young researcher who has successfully completed her doctoral studies on polyfluorinated alkyl substances in the marine atmosphere. The proposed 24-month project seeks to extend her competencies to internal exposure, bioaccumulation and bioavailability of organic contaminants. The missing link between external concentrations of persistent organic pollutants (POPs) and their levels at target sites in organisms where adverse effects occur will be investigated. This research issue is fundamental for risk assessment of contaminants. The training program consists of three research objectives: (1) Internal exposure: Develop equilibrium sampling methods to measure chemical activity / fugacity of POPs in biota; use them to test the hypothesis that POP fugacity is the same in different tissues throughout a given organism. (2) Bioaccumulation: Explore bioaccumulation in marine food webs from the Baltic Sea by measuring the fugacity of a given POP at different trophic levels. (3) Bioavailability: Develop methods to measure the freely dissolved concentration of POPs in water and sediment, which is equivalent to the chemical activity / fugacity. Use them together with the above methods to explore bioavailability effects on bioaccumulation, and to determine differences in POP fugacity between benthic and pelagic organisms as well as their respective environments. An additional component of the training program will provide the applicant with important complementary competencies including research supervision and project management. This completes a program which is carefully matched to the applicant´s needs and exploits the unique possibilities at Stockholm University and the Danish National Environmental Research Ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Genetic resolution of myopathies: european cluster'.

assistant: **Concept**

The MYO-cluster is a cluster presenting a collection of three proposals, which have been designed and prepared throughout 1998. The working group was formed in late 1997, to become a cluster only when the EU published information on such a possibility. The working group, up to that point, was dedicated to coordinating research efforts across Europe by introducing planning, monitoring and control functions into scientific collaborations. A wide number of participants were involved, and a total of seven projects were prepared. For this call, three of the projects were considered to be particularly relevant and homogenous to be presented under this cluster. A2 forms are provided for each project. A3 forms are all grouped together for cluster partners. A4 forms are provided for each project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Degradation of ozone-depleting methyl halides in the troposphere characterized by isotopes' (DEMETROPIS).

assistant: **Concept**

The stratospheric ozone layer is an important shield to protect life on earth. Most of the short-waved UVB radiation is absorbed which otherwise would cause skin cancer and genetic damage. Destruction of the ozone layer by halogen radicals was discovered in the 1970s and consequently production of many halogenated compounds was curtailed. Methyl chloride (CH3Cl) and methyl bromide (CH3Br), important contributors of halogens in the stratosphere, are emitted by both natural and anthropogenic sources but significant gaps remain in the calculated atmospheric budget due to uncertainties concerning formation mechanisms and/or overestimation of degrada-tion processes. In this study a conceptual framework will be developed to apply innovative multi-element isotope analysis (2H, 13C, 81Br, 37Cl) for delineating sources and sinks of methyl halides, reducing the budget uncertainties and discrepancies. The specific aim is to isotopically identify and characterize oxidation of methyl halides by hydroxyl radicals, the main degradation process, both to understand the fate of these important pollutants in the environment but foremost to resolve the impact on any future isotope based approach for source apportionment. The results of this project will also have broader impact as the information and interpretational frameworks developed will be applicable to research on other environmentally relevant gases, e.g. greenhouse gases. Returning to the EU the applicant will expand his own doctoral experiences obtained in Sweden, and bring to the proposed work his innovative experiences and techniques on CFCs developed through his current post-doctoral research in Canada. Therewith this project not only counteracts brain drain but, based on the unique combination of expertise of all contributors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting N2O emission hot-spots in dairy pastures for mitigation action: microbes, stable isotope methods and modelling' (Target-N2O), addressing dissemination and exploitation.

assistant: **Impact**

Nitrogen (N) limits primary productivity in most terrestrial ecosystems, which has led to increased use of N fertilisers within farming systems. The amount of reactive N in global circulation has more than doubled; this has global significance as the N can cascade through different chemical forms in land, air and water, leading to a range of human health and environmental impacts. In order to achieve sustainable food production systems of the future, there is a need to improve knowledge on the best management of farm N, especially under increased demand for food production under a burgeoning human population. The Target-N2O project will deliver a high quality training-through research project aiming to improve N use efficiency and reduce emissions of the powerful greenhouse gas, N2O, from intensive dairy farms. The project will combine multi-disciplinary techniques in a novel way, including molecular ecology, stable isotope methods and whole-farm system modelling to determine the cost-benefits of an N loss mitigation strategy. The strategy would be to apply nitrification inhibitors to pasture areas which have been identified as farm-scale N2O emission hot-spots (e.g. areas of pasture around gateways, livestock shelter areas and camping areas). Such areas receive regular inputs of nutrients including labile N (through urine events) and carbon sources (via dung), which fuel microbial processes leading to enhanced and spatially variable GHG emissions. Evidence of the effectiveness of nitrification inhibitors to reduce N losses from these areas are lacking. The results of the action will have cross-sectoral impact (scientists, dairy and fertiliser industries and policy makers). The project will deliver decision support tools for farmers utilising such a mitigation strategy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fundamentals of the Nonlinear Optical Channel'.

assistant: **Innovation**

Fibre optics are critical infrastructure for society because they carry nearly all the global Internet traffic. For a long time, optical fibre systems were thought to have infinite information-carrying capabilities. With current traffic demands growing by a factor between 10 and 100 every decade, however, this is no longer the case. In fact, it is currently unknown if the installed optical infrastructure will manage to cope with these demands in the future, or if we will face the so-called ""capacity crunch"".To satisfy traffic demands, transceivers are being operated near the nonlinear regime of the fibres. In this regime, a power-dependent nonlinear phenomenon known as the Kerr effect becomes the key impairment that limits the information-carrying capability of optical fibres. The intrinsic nonlinear nature of these fibres makes the analysis very difficult and has led to a series of unanswered fundamental questions about data transmission in nonlinear optical fibres, and nonlinear media in general. For example, the maximum amount of information that optical fibres can carry in the highly nonlinear regime is still unknown, and the design of transceivers well-suited for this regime is also completely unexplored.In this project, the PI will answer these fundamental questions by studying the simplest nontrivial building blocks underlying optical fibres, and will give a definitive answer to the capacity crunch question. The PI will use a systematic methodology that aims at embracing nonlinear effects, consider the continuous-time channel as the correct starting point for analysis, and redesign optical transceivers from scratch, lifting all linear assumptions. The proposed methodology is in sharp contrast with current research trends, which aim at mitigating nonlinearities,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'OrganVision: Technology for real-time visualizing and modelling of fundamental process in living organoids towards new insights into organ-specific health, disease, and recovery', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

OrganVision is a revolutionary technology proposition that will break new grounds in microscopy and develop an ideal imaging solution for organoid research. It will enable life scientists to visualize life unfolding in real-time inside the cells and tissue in an organ-mimicking living tissue environment (called organoid here). It will alter the paradigm in microscopy by converting the central obstacle of light scattering by thick samples into the central opportunity that enables 3D label-free imaging on organoids in real-time with sub-cellular (~200 nm) and inter-cellular resolution (~1 um) at speeds of >1 volume per second (cube of 100 um). For achieving this unprecedented feat, OrganVision will develop a new multi-physics solver that solves transport of intensity (ToI) and full wave electromagnetic (FWEM) models in a coupled manner. ToI provides 3D image with inter-cellular resolution and generates intensity distribution inside the sample. FWEM uses this intensity distribution to decode the near-field light interaction between the sub-cellular entities for generating 3D sub-cellular image. A novel microscope instrument delivers custom designed 3D illumination patterns at the speed of 200 patterns per second in order to solve the problem of ill-posedness encountered by these solvers. In order to exploit the opportunity thus created, OrganVision will develop an a computational model that models the dynamics and interactions of functional entities recorded by OrganVision imaging solution in order to identify the underlying mechanisms. The proof-of-concept will be shown on engineered heart tissue for real-time imaging of cell and tissue activity towards studying injury, repair and regeneration in heart muscle. OrganVision will transform microscopy from a visualization dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COordination and iMplementation of a  pan-European instrumenT for radioecology' (COMET), addressing dissemination and exploitation.

assistant: **Impact**

COMET will strengthen the pan-European research initiative on the impact of radiation on man and the environment by facilitating the integration of radioecological research. COMET will build upon the foundations laid by the European Radioecology Alliance (ALLIANCE) and the on-going FP7 STAR Network of Excellence in radioecology. By collaborating with the European platforms on nuclear and radiological emergency response (NERIS) and low dose risk research (MELODI), COMET will significantly aid preparation for the implementation of the Horizon 2020 umbrella structure for Radiation Protection.In close association with STAR and the ALLIANCE, COMET will take forward the development of a Strategic Research Agenda as the basis for developing innovative mechanisms for joint programming and implementation (JPI) of radioecological research. To facilitate and foster future integration under a common federating structure, research activities developed within COMET will be targeted at radioecological research needs that will help achieve priorities of the NERIS and MELODI platforms. These research activities will be initiated in collaboration with researchers from countries where major nuclear accidents have occurred. Flexible funds, unallocated to specific tasks at project initiation, have been included within the COMET budget to facilitate RTD activities identified through the JPI mechanisms developed that are of joint interest to the ALLIANCE, NERIS and MELODI. It will also strengthen the bridge with the non-radiation community. Furthermore, COMET will develop strong mechanisms for knowledge exchange, dissemination and training to enhance and maintain European capacity, competence and skills in radioecology.The COMET consortium has 13 partners, expanding from the organisations wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Functional annotation of microbial communities in human health and in the environment' (SIFTERMETAGENOMICS) targeting Seventh Framework.

assistant: **Abstract**

In metagenomics the microbial genomes are studied directly in their natural habitats, which obviates the need of isolation and cultivation of individual species. In this study, we will use metagenomics techniques in the analysis of microbiota from the human gut. Crohn's disease is a chronic inflammatory disease of the digestive tract affecting about a million individuals worldwide. The incidence of Crohn's disease has increased during the past decades, however, the cause of the disease remains unknown. The amount of data created by this study is immense and effective computational approaches are needed for analysis. Especially the function prediction of novel proteins is of great importance, since sequences without molecular function annotation are of limited use to us. Automated phylogenomics is one of the most promising ways of having consistent reliable protein annotations that is applicable on a large scale and particularly for metagenomics information. SIFTER, a prototype tool for automated phylogenomic protein function prediction, has been shown to annotate ten times more proteins on tested protein families compared with the traditional method, BLAST. In this study, unique aspects of the metabolic and signaling capacities of microbiota from the inflamed gut of Crohn's patients versus undiseased tissue will be analyzed, with an ultimate long-term goal of understanding how microbial communities contribute to Crohn's disease and how treatment may be improved. To reach this goal, the SIFTER protein function prediction method will be refined to work on metagenomic data. SIFTER will then be applied to analyze sequences sampled from diseased and healthy intestinal tissue. The work of this proposal will be performed in two very high-quality host organizations in Berkeley,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Auto-tuning, manipulation and braiding of topological quantum bits in tapered nanowire networks' to be submitted under Horizon Europe.

assistant: **Abstract**

Quantum computers will revolutionize multiple technology fields which will have a massive impact on society, in areas such as communication, healthcare, machine learning & artificial intelligence, finance, materials research and development and aerospace designing. Currently, the commercialization of quantum computers for real life applications is still a long shot due to major technical challenges like decoherence, a process in which the environment interacts with quantum bits and changes their quantum behavior causing computing errors.Topological quantum computer platforms offer an alternative route where the topological nature of quantum bits protects them from decoherence, therefore not needing error correction protocols that constraint development of commercial quantum computing systems. These mainly rely on Majorana zero modes, which are topological boundary modes predicted to be decoupled from decoherence. Topological computation is achieved by braiding of Majorana zero modes, but their manipulation is still an experimental challenge.The TopoTapered project aims to develop tapered nanowires and tapered nanowire networks as a scalable technology for auto-tuning, transportation and braiding of Majorana zero modes bound at ends of topological superconducting segments. The innovative tapered nanowire platform for quantum computers will support topologically protected quantum bits making it possible to incorporate the large number of them needed for processing quantum information in quantum computers. Hence, TopoTapered will develop a simplified quantum computer architecture which will be both robust and scalable and therefore will shorten the time to market for quantum computers. Furthermore, to ensure the successful commercialization of our innovation, we will ident