RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intestinal Gluconeogenesis: Emerging Regulator of Energy Homeostasis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Obesity and type 2 diabetes continuously progress worldwide, compromising healthy aging. Deregulated endogenous glucose production (EGP) is involved in hyperglycemia and its complications. Among the 3 organs (liver, kidney, intestine) contributing to EGP, I uncovered with my team that intestinal gluconeogenesis (IGN) has the capacity to interfere in the control of energy homeostasis. Indeed, intestinal glucose initiates a gut-brain circuit controlling both body weight and glucose production by the liver, the strongest quantitative contributor to EGP. Intestinal gluconeogenesis is, thus, a novel target to control obesity and diabetes. The IGN project has 3 objectives:Understand: is dedicated to elucidating the neural mechanisms by which IGN is sensed and send its signals to the brain. Our data suggested that glucose receptor sodium-glucose co-transporter 3 (SGLT3) could be the peripheral sensor of IGN. Moreover, we showed that the neuromediator calcitonin gene-related peptide alpha (CGRPa) is mandatory for the IGN signal. I will use original mouse models to map the SGLT3-neuron connection to the brain and define the role of CGRPa.Explore: aims at expanding the scope of IGN to the networking of hypothalamus during the neonatal period. I will assess whether the surge of IGN occurring during the neonatal period may control the development of neuronal connections between the hypothalamic nuclei, to ensure an optimal control of energy homeostasis in adult, as previously observed for the neonatal surge of the hormone leptin. Take advantage: aims at identifying novel metabolites able to activate IGN and test them as beneficial modulators of energy homeostasis under unbalanced nutrition. This will pave the way to novel therapeutic approaches of metabolic diseases based on IGN.Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DEVELOPMENT OF A EUROPEAN SERVICE FOR INFORMATION ON RESEARCH AND EDUCATION' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

DESIRE will examine how to satisfy research user requirements for better access to research-related information on the WWW. The project will pursue ways of facilitating the search, access, study and retrieval of multimedia resources related to research. It will also develop and validate tools for the creation, quality, cost-recovery and description of information resources and security mechanisms to control access to them. The project will also look into measures for reducing the network load of multimedia information services. Despite legal problems concerning the security of transnational information services, the technologies developed will have unquestionable potential exploitation for information providers and network operators alike.In the context of a European information network based on the World Wide Web (WWW), DESIRE aims to comprehensively address the areas in which existing services fail to adequately meet the needs of research users. In particular, DESIRE aims to provide:- a sustainable approach to making searching, finding, browsing, accessing and retrieving multimedia resources as easy as possible - tools for the creation, maintenance, quality, cost-recovery and description of information resources- security mechanisms to control access to information resources for reasons of confidentiality or charging- quality mechanisms to permit the quality of information and information services to be monitored and reported- performance features to reduce the international bandwidth requirements of access to multimedia information across EuropeComponent technologies (caching, indexing methods) have clear possibilities for exploitation by providers of information services and by network operators, although the legal problems of providing secure information services,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Light for Clocks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main objective of this proposal is to build novel, robust light sources for a transportable optical clock and to contribute, thereby, to the future redefinition of the second by providing a low-uncertainty link between institutes operating optical clocks. This grant will also enable the applicant to continue to collaborate with his former group and collaborators in the field of attosecond XUV physics. The applicant hopes to apply techniques from his former field to push frequency comb technology into the XUV regime and thus to contribute to the emergence of precision XUV spectroscopy/frequency metrology and nuclear clocks.Time and frequency metrology is going through the greatest changes since the first demonstration of the Caesium atomic clocks in the 1950’s. This revolution is caused by the arrival of optical atomic clocks, the development of which was sparked by the demonstration of self-referencing femtosecond frequency comb technology in 2000. In essence, frequency combs make it possible to count optical cycles.The potential for great performance improvements over Caesium atomic clocks have been known for a long time, but it was not until suitable clockwork was found that considerable progress was made. Today, several groups already report fractional uncertainties down to 10E-17, thus beating the best Caesium clocks by an order of magnitude. Time and frequency are the two quantities that can be measured the most precisely, and the unit of time is considered the most fundamental base unit. Thus, the development of optical clocks is expected to have widespread impact on science and our daily lives; however, before that happens, several technological and fundamental challenges must be overcome. A clear challenge is to develop more accurate methods to compare the f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The european wolbachia project: towards novel biotechnological approaches for control of arthropod pests and modification of beneficial arthropod species by endosymbiotic bacteria' (EUWOL), addressing dissemination and exploitation.

assistant: **Impact**

Wolbachia may be the most abundant and widespread intracellular symbiotic as yet described. Thisunculturable, maternally inherited bacterium is able to invade and maintain itself in numerous arthropod host species by inducing a variety of reproductive alterations such as induction of parthenogenesis development uncertain parasitic wasps, overriding chromosomal sex determination to convert infected genetic males into functional females in crustacean species (feminisation), and most commonly induction of cytoplasmicincompatibility (CI), a form of embryonic lethality in crosses between males and females of different Wolbachiainfection status. This proposal aims to identify the bacterial and host genes involved in the induction of these reproductive phenotypes through an integrated genomic, polemics and post-genomic approach. Identification of these genes will be a major breakthrough towards the goal of using them for applied purposes, for example management of arthropod agricultural pests and disease vectors or provident of beneficial arthropods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimisation of the linguistic input in the first years of life' (OptimisingIDS) targeting Horizon 2020.

assistant: **Abstract**

Parents have direct access to one of the most effective child development tools - their own infant-directed speech (IDS). Access to rich linguistic input allows infants to develop language abilities in a rapid and effortless manner in their first years of life. These basic language skills are essential for efficient and effective acquisition of literacy skills and knowledge in all other academic areas when children start early formal education. However, not all children acquire these basic language skills to the same extent, giving some children a significant advantage even before they start school and leaving many others behind. Understanding how the early language environment can impact and enhance early learning language processes can inform not only the strategies for closing this gap in language ability, but the strategies to prevent it from emerging in the first place. This fellowship specifically focuses on investigating the language input of bilingual infants during their first 12 months of life, and it comprises two parts. Part 1 will identify the individual acoustic and linguistic components present in natural parental IDS. Detailed acoustic and linguistic analyses of natural speech recordings will be conducted. Part 2 will systematically measure the role of each individual component of IDS in facilitating infants’ performance in language processing tasks. Behavioural and neurophysiological measures of infants’ language processing (native speech perception, continuous speech segmentation, and neural entrainment to the speech signal) will be conducted. This project is the first to implement a combined analytical and experimental approach to the study of early linguistic input. The findings of this fellowship will allow us to identify the components of IDS criti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Trans-European Research Training Network on Engineering and Provisioning of Service-Based Cloud Applications' (RELATE), addressing dissemination and exploitation.

assistant: **Impact**

Background and motivation:The combination of cloud computing, service-orientation, and on-demand application delivery is bringing about a paradigm shift in our ways of computer usage. As the software industry moves closer to service-based application engineering and cloud-based application delivery, the traditional models, methodologies, and technologies for developing and offering software applications are becoming increasingly challenged. Emerging questions and research challenges form a vibrant new field with tremendous industrial innovation potential in which Europe needs to establish excelling research. Timely and focused education of future researchers in this area is therefore essential.Major objectives:• The RELATE Initial Training Network aims to establish a network of international academic and industrial partners for a joint research training effort in the area of engineering and provisioning service-based cloud applications. The training is intended to not only shape high-level academic researchers, but also educate next generation experts and innovators in the European software industry.• Through an integrative and multidisciplinary research approach, RELATE aims to promote the advancement of the state of the art in the related areas of model-driven engineering and formal methods, service-based mash-ups and application integration, security, performance, and trust in service-based cloud applications, and quality management and business model innovation.Consortium:The RELATE Initial Training Network joins organisations with internationally recognised research activities in the area of engineering and provisioning of service-based applications. At its core, the network consists of five academic organisations and two companies from Germany, Greece, France, UK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Antibody mediated enhancement and neutralization of lentivirus infections: role in immune pathogenesis and vaccine development'.

assistant: **Innovation**

- To elucidate the molecular mechanisms underlying antibody mediated neutralisation and enhancement of lentivirus entry- to determine similarities in structure-function relationships in antibody mediated neutralisation and enhancement of HIV-1, HIV-2 and FIV entry- to determine the role of antibody mediated neutralisation and enhancement of lentivirus infection in pathogenesis and vaccine developmentSUMMARY Virus neutralizing antibodies are generally considered to play a major role in the pathogenesis and immune mediated protection of lentivirus infections. Recently others and we have shown that -both in vifro and invivo- these antibodies may mediate enhancement rather than protection against virus infectivity in primate and feline lentivirus systems. The outcome of the virus-antibody interaction proved to be determined by the molecular structure of the viral envelope glycoproteins and should therefore be directly influenced by their genetic variability. Antibody specificity proved to be of secondary importance only. Especially in the light of ongoing clinical trials with candidate HIV and FIV vaccines this issue has raised major concern, since vaccination with currently considered vaccines could induce antibodies that paradoxically, may rather increase susceptibility to infection and accelerate disease progression. Furthermore it raises concerns about certain vaccine development strategies. The project aims to elucidate mechanisms involved in antibody mediated virus neutralization and enhancement at the molecular level, with special emphasis on the structural features which determine the efficiency of lentivirus entry.To this end the following objectives will be pursued:In vitro identification of primate and feline lentivirus envelope regions, directly involved in anti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pathway-based Secretomes in Breast Cancer Biomarker Discovery', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Improvements in the characterization of human tumors have resulted in better survival rates for cancer patients. However, less progress has been made in the development of clinical tools to monitor the course of the disease. Tumor markers have not had a broad acceptance in the clinical community, because the few that are known are organ rather than tumor specific. Proteomics biomarker discovery research is usually a brute-force effort, and suffers from lack of reproducibility and high biological sample complexity. There is need for proteomics hypothesis-driven biomarker discovery approaches that incorporate technology advances with understanding cancer at the molecular level. I propose a biomarker discovery approach that combines exploiting the tumor cell’s communication with its microenvironment and with the rest of the organism, with a proteomics method designed to specifically measure secreted proteins (the ‘secretome’). My hypothesis is that signaling pathways are altered during tumorigenesis, and that these alterations are translated into protein differential secretion, which potentially can be used to discover secreted markers. The strategy proposed entails generating breast cancer secretome signatures and mine them to discover secreted pathway-based biomarkers. There is great hope that the discovery of pathway-based biomarkers in breast cancer secretomes will facilitate individualized diagnostics and treatment of breast cancer patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Life on a leaf: species interactions and community dynamics in epiphyll communities', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Why are there so many species in the tropics? Ecologists have no definite answer to this question. While theories explaining biodiversity maintenance have arisen in the past few decades, testing them with empirical data in tropical rainforests can be challenging because of the slow dynamics of tree communities. By focusing on bryophytes and lichens living on leaves - ‘epiphylls’ - EPIDYN aims to test the two main types of biodiversity theories in an ecological system of much faster dynamics and easier replication than tropical rain forests, while maintaining similarly high levels of biodiversity.To this end, leaves will be monitored in a tropical rainforest in Panama under different light and moisture conditions -  the most limiting factors for bryophytes and lichens in tropical rainforests. In so doing, EPIDYN will be the first study to explicitly address species interactions and community dynamics among epiphyll species within leaves.Theoretical models of biodiversity maintenance in plant communities range from ‘neutral theories’ to niche-based models. In both types of models, species interactions play an important role, but the predicted outcomes differ. For example, in vegetation succession, the neutral ‘priority effect’ predicts that any first species to arrive in a new habitat will dominate, while models favoring ecological niches consider a range of species interactions, both negative (competition, allopathy) and positive (facilitation). In this project I aim to determine: (1) which are the most appropriate theoretical models to describe species interactions and successional dynamics in epiphyll communities, and (2) how the relative applicability of each model depends on environmental conditions. Using state-of-the-art spatial pattern analysis as well as innovati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Scattering Strings and Other Things: A Modern Approach to Quantum Gravity and the Conformal Bootstrap'.

assistant: **Innovation**

What is the space of consistent conformal field theories (CFTs) and of theories of quantum gravity?What are the underlying physical and functional structures of AdS scattering amplitudes and large N CFT correlation functions?Can we construct string and M-theory from precision CFT computations?The conformal bootstrap program continues to generate remarkable insights into the foundational nature of quantum and conformal field theories. In the context of the AdS/CFT Correspondence, these are directly transmuted into bounds on, and properties of, the space of consistent theories of quantum gravity in anti-de Sitter spacetime (AdS). Guided by the core questions listed above and the need for new approaches to string and M-theory, I propose to develop new analytic methods within the conformal bootstrap, particularly in the context of the AdS/CFT Correspondence, with application to fundamental questions in quantum gravity including string/M-theory. The project will draw from cutting-edge techniques in CFT and in gravity, with special focus on the computation of correlation functions and their dual AdS scattering amplitudes. Specific goals include the extension and generalization of the traditional tenets of the conformal bootstrap; the explication of holographic methods for systematically computing loop-level scattering amplitudes in AdS; via AdS/CFT, a novel determination of perturbative scattering amplitudes in string and M-theory at both tree- and loop-level; and the discovery of rigorous constraints on the space of AdS vacua of string and M-theory and, by extension, on the emergence of bulk spacetime from conformal field theory microscopics.


**Keywords:** Conformal field theory, AdS, CFT Correspondence, conformal bootstrap, string theory, M-theory, scattering amplitudes,