RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NEBU-ONE : A revolutionary method for anatomic pathology slides staining'.

assistant: **Innovation**

Anatomic pathology laboratories (APL) across Europe have a responsibility to urgently modernize and sustain increasing efficiency, leverage automation, and foster patient safety. Misidentification errors in laboratories have the capability to cause devastating events, both at medical and economic level. It is estimated that 30% of cytological cell samples are misinterpreted as negative for cancer. That represents 1.65 millions of samples per year. One of the most important problems for APL is the increase of the number of biological screening samples to be processed due to the lengthening of the lifetime and increased number of cancers. Only screening of cervical cancer, which represents today about 200 million tests worldwide and the market of about 1 milliard of euros, should double by 2020.Optana Technologies is developing a breakthrough medical device called NEBU-ONE, for highly improved and automated biological sample staining. NEBU-ONE contains a proprietary “nebulization heads” which deposits staining reagents in the form of aerosol (microdroplets) allowing them to penetrate much deeper and much faster into the tested samples (cells and tissues) compared to standard techniques. Often present cross-contamination between samples will be also decreased, as well as a consumption of expensive and pollutants reagents. All these will lead to increased quality of sample staining, improved accuracy of the analysis and interpretation and better diagnosis and patient care. It will allow Optana Technologies to become the reference method in the APLs and to grow rapidly in the European market. We plan to achieve the turnover of 4.3 M€ in 2020 and create 5 new highly qualified post. This feasibility study is essential to validate our innovative business model and NEBU-ONE befo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coastal flood risk in Europe and the socio-economic impacts in a changing climate' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A large portion of the coastal population worldwide, including Europe, is already vulnerable to extreme high sea level events. In the future it is expected that climate change will increase coastal flood risk making costly adaptation inevitable. In order to help develop robust and flexible coastal management strategies, decision makers need to explore how, when, and where future changes in the physical environment will require immediate action. This is aggravated by the existence of large uncertainties in climate projections. Impact assessment models, such as the Dynamic Interactive Vulnerability Assessment (DIVA) model, have been used extensively to assess the socio-economic impacts associated with coastal flooding under climate change and to explore the benefits of mitigation, adaptation, and migration. However, because the DIVA model is applied at broad scales, it is based on a number of significant assumptions. Most notably, present-day return water levels (one of the key forcing parameters in the model) were derived using a simple global approach. Moreover, decadal variations in storminess and associated changes in future return water levels were ignored. Storm surges and river floods were assumed to be fully independent and vertical land movement rates were approximated with a global glacial isotactic adjustment model ignoring other potential contributors, such as land subsidence associated with ground water extraction. These shortcomings will be specifically addressed within the fellowship at the European level. The results will be used along with existing data bases and model infrastructure to develop a regional version of DIVA. The latter will be applied to perform the most comprehensive and realistic (in terms of temporal variations) mesoscale flood risk analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of cell culture models of infectious forms of TSE' to be submitted under Fourth Framework.

assistant: **Abstract**

This proposal aims primarily at developing improved or new cell culture systems in which infectious agents (or prions) causing Transmissible Spongiform Encephalopathies in human or animals can be propagated. Although the propagation of rodent-adapted TSE agents has been achieved in a few cell lines, there is an obvious need for more reliable, manipulatable and more informative in-vitro systems which would be able to support the replication of TSE agents infecting rodent as well as other species. Three major objectives of the project are: i) to derive primary and established cell culture systems and to evaluate them for their ability to propagate or to be infected by a TSE agent ; ii) to express natural or engineered mutants forms of the host-encoded PrP protein as a means of elucidating its role in the cell susceptibility and of increasing permissiveness to the infectious agent ; iii) to investigate the molecular events leading to the conversion of the normal protein into its pathological isoform (PrPsc), a key feature in the TSE infection process. Three groups with both common and specific expertises have decided to interface in order to achieve the above objectives. Their collaboration will allow the implementation of a set of complementary approaches focused mainly on the ovine and the murine species. The proposed cell systems will mostly involve cells derived from the central nervous system, including neurons, but also peripheral cells, such as resident dentritic cells. Cell clones overexpressing normal, mutated or hybrid PrP-encoding genes from different animal species will be isolated. The cultures will be infected with TSE agents through incubation with infectious materials, mainly from natural ovine scrapie and mouse-adapted strains, or co-cultivation with alrea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Preclinical concept validation of tumor endothelial cell metabolism for novel anti-angiogenic therapy'.

assistant: **Objectives**

MAIN GOAL: To characterize the metabolic changes, fuelling growth of tumor endothelial cells (TECs) versus normal healthy endothelial cells (NECs), and identify & validate metabolic genes, deregulated in TECs, as targets for anti-angiogenic cancer therapy. BACKGROUND & RATIONALE: Tumors stimulate blood vessel growth (angiogenesis) to nourish cancer cells, but current anti-angiogenic treatments lack sufficient efficacy. NECs are widely used for anti-angiogenesis development, but TECs, the real target cells, have been dismissed, even though they differ fundamentally from NECs. We pioneered NEC metabolism research and demonstrated that inhibition of specific metabolic pathways can block angiogenesis. Nothing is however known on TEC metabolism. I hypothesize that TECs “hyper-activate” their metabolism in a tissue-specific manner, and that targeting TEC metabolism is a novel concept for inhibiting tumor angiogenesis. METHODOLOGY: We will perform a transcriptomic and metabolomic analysis of TECs & NECs isolated from cancer patients, use an in-house developed bioinformatics platform (BIOMEX) to analyze the omics data in order to rank deregulated metabolic genes, and construct TEC-tailored genome scale metabolic network models (GEMs) allowing in silico computational modeling to predict metabolic targets that affect TEC but not NEC growth. The in vitro angiogenic activity of top targets will be biologically validated directly or after a negative selection shRNA-based screen, followed by validation in preclinical tumor models in vivo, using conditional knockout mice. All procedures are operational. Deliverables include in vivo validated metabolic targets, driving tumor angiogenesis.  NOVELTY, OVERALL & CLINICAL IMPACT: These pioneering studies on TEC metabolism promise to open up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chip Architectures by Joint Associated Labs for European Diagnostics' (CAJAL4EU).

assistant: **Concept**

The main objective of the ENIAC JU project CAJAL4EU is to develop miniaturised biosensor technology platforms enabling diagnostic test manufacturers to build multi-parameter in-vitro test applications rapidly in a robust, user-friendly and cost-effective way. They will involve nanoelectronic-based transducers with chemical sensing capabilities providing the interface with the clinical samples. In contrast to other biosensor technologies, these devices will be capable of integration with low-cost CMOS nanoelectronics. The cost of a nanoelectronic biosensor can be ultra low at high volumes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Theoretical Developments and Empirical Measurement of the External Costs of Pesticides' (TEAMPEST).

assistant: **Innovation**

Pesticides are defined as chemical substances protecting plants from pathogens, insects, nematodes and weeds. They are used to secure yields, improve quality of food and facilitate harvesting. However, their heavy use in agriculture resulted in pest resistance, ground, surface and water contamination as well as possible health problems on farmers/operators and consumers. Within this context, the objective of the proposed research stems from the need to provide a solid methodological framework and empirical evaluation which will assist policymakers in identifying the true impact of pesticides on agricultural production. The obtained results may well serve as a benchmark for the foundation of future EU policy schemes aiming at achieving a sustainable use of pesticides in European agriculture. In this respect, the proposed project intends to provide an accurate assessment of the external costs of agricultural pesticide use and contribute to the relevant EU policies by developing tools for designing a socially optimal tax and levy scheme aimed at the reduction of pesticide use to its socially optimal level. Specific consideration will be given to the effects of the accrued scheme and alternative policy tools on the socially optimal pesticide use, as well as on economic sustainability and social welfare. Moreover, the proposed research will identify means that can help in the promotion of more integrated pesticide management practices. The project fulfils its aims by combining traditional and well-established theoretical methodologies with the most recent advancements in economic theory, biological and technical scientific work, ultimately developing a consistent and integrated analytical framework. The validity of the employed theoretical models and policy tools will be ext
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Critical Raw Materials Innovation Network – Towards an integrated community driving innovation in the field of critical raw material substitution for the benefit of EU industry'.

assistant: **Concept**

The overall aim of the project is to create an integrated community that will drive innovation in the field of critical raw material substitution for the benefit of EU industry. The project will:•Deliver a mapping of on-going initiatives in the field of substitution of CRM at the EU level and Member States that will allow for the identification of key champions and synergies. The mapping will also consider other initiatives of international character.•Develop a methodology to establish clear criteria for the prioritisation of applications which are at ‘threat’ and the technological and non-technological needs regarding the substitution of CRM.•Propose a roadmap for the substitution of CRM in coordination and cooperation with all stakeholders across the CRM substitution value chain while paying close attention to the specificities of critical industrial sectors as well as possible synergies.•Create one or more Pole(s) of Excellence in the field of substitution of CRM that will ensure the relevance and usefulness of the project results and constitute a dynamic, open and proactive platform for the entire stakeholder community aiming to support and enhance the competitiveness of the EU industry and economy. CRM-Innonet will carry out a feasibility study considering the potential models and routes for this Pole(s) to endure after the project termination and decide upon concrete future actions in this respect.•Prepare a document containing recommendations, future initiative ideas and suggested actions for policy makers with the widest possible endorsement and consensus of all stakeholders involved.The CRM-InnoNet consortium is comprised of recognised and experienced key actors across the value chain of substitution of CRM representing academia, research establishments and ind
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced software-based seRvice provisioning and migraTIon of legacy Software' (ARTIST) under Seventh Framework.

assistant: **Objectives**

Successful software has to evolve to keep it compatible and up to date. Up to 90% of software cost  is spent on maintenance and of this 75% is spent on the development of new features for staying competitive. The industry progresses through periods of incremental development interlaced with true paradigm shifts.<br/>We are currently experiencing one of these paradigm shifts, as remarked by the European Commission: The speed of change in Internet technologies continues to be impressive. Software is becoming more and more pervasive: it runs on the devices that we use every day ...[opening] a new world of possible applications" cf. Cloud computing, Internet of Services and Advanced Software Engineering, European Union, 2011 (doi:10.2759/47598).<br/>Accordingly, more and more traditional software vendors notice the need to transform their current business and technology model in order to remain competitive. Software-as-a-Service (SaaS) is seen as the most promising way to achieve this change. However, this transition from Software-off-the-shelf (often residing as legacy applications) to SaaS is a tremendous challenge comprising business, application and technical issues.<br/>Having an automated, vendor, technology and hardware independent way to migrate an application would permit the software to evolve easily even in case of transition to new paradigms.<br/>ARTIST proposes a software migration approach covering the premigration and postmigration phases. The premigration phase analyzes the technical and non-technical consequences of migrations, supporting the decision-making process on how a migration should be done. The migration phase itself is based on Model Driven Engineering techniques to automate the reverse engineering of the legacy applications to platform independe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Defining the pathways and mechanism of misfolded protein triage and quality control in eukaryotic cells' (FOLDEG) targeting Seventh Framework.

assistant: **Abstract**

Proteins need to be correctly folded to carry out their biological function. Failure to fold leads to aberrant protein conformations that have an increased tendency to aggregate and have deleterious effect on cell viability. Eukaryotes have developed a sophisticated protein quality control (QC) system that protects cells from misfolded or incompletely synthesized polypeptides that would otherwise interfere with normal cellular functions or even induce cellular death. The QC system may promote refolding of these non-native proteins by molecular chaperones, enhance their degradation by the ubiquitin-proteasome system or autophagy, or terminally sequester these misfolded proteins in inclusion bodies called IPODs. Impairment of the activity of this QC system, for instance due to ageing or disease, is thought to underlie the growing number of  age-related aggregation disorders, such as Parkinson, Alzheimer and Huntington disease, all of which are characterized by accumulation of misfolded aggregated proteins. At present, it remains largely elusive how the quality control machinery recognizes misfolded proteins, and how the triage decision is implemented: i.e. why certain misfolded proteins are refolded whereas others are targeted for degradation or sequestered in cellular inclusions. The goal of this project is therefore to identify the played of the QC machinery and define how the interplay between molecular chaperones and degradation pathways maintain cellar protein homeostasis. The proposed work will build on the large body of work of the host laboratories and will combine systems approaches with cell biology and biochemistry to address these important questions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'EUROPEAN NETWORK ON COASTAL RESEARCH' under Sixth Framework.

assistant: **Concept**

The CA addresses 3 major causes for stagnation in the implementation of ICZM in Europe:(A) Fragmentation of coastal science, practice and policy;(B) Difficult communication between science, policy and practice;(C) Lack of multidisciplinary approaches. ENCORA is a European network structure with new mechanisms for communication on shared problems within and between the communities of coastal science, policy and practice. In 13 European countries National Coastal Networks have been established; in other countries the establishment of a National Network is anticipated. Ten trans-national, cross-disciplinary Thematic Networks, led by institutions with outstanding expertise, address major ICZM issues; they include participants from all EU countries, including those where a national network is not yet established. Operational nodes are created between the National and Thematic networks and other existing coastal networks. National Network Offices take care of the process of knowledge exchange and cooperation between network participants Europe-wide. They establish through all the affiliated networks a contact search mechanism for knowledge sharing and cooperation, by raising information-exchange communities, organising an exchange-visit programme for young researchers/practitioners, by organising Communities of Practice and by project intertwining. The Thematic Networks produce a state-of-the-art overview of knowledge, tools and practices, a European ICZM training and education curriculum and a European ICZM training and education curriculum and European Action Plans for addressing priority issues for ICZM implementation. The networking structure and processes are continuously improved by an incorporated feedback-learning cycle. After 3 years the project will deliver an opera