RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Development of light-weight steel castings for efficient aircraft engines'.

assistant: **Objectives**

The aim of the proposed project is to develop castable steel alloys for aero engine applications and to refine the process to be able to cast thin-walled, light-weight and durable cast steel components. Today, cast titanium components is the predominant choice over alternatives like nickel base alloys and stainless steels for critical components in the aero engine. The main downside of using cast titanium components is the additional cost accompanied with the material. Using a technically equivalent, but cheaper construction material leaves more economical headroom for using higher performing light-weight materials in other part of the air craft, thereby making it possible to manufacture lighter air crafts producing less emission during its active usage cycle. In the proposed project the possibility to cast thin-walled cast steel components will be investigated using an iterative process of performing casting trials and tuning simulation parameters for simplified geometries. After a successful methodology has been developed and validated, complex aerospace-engine components will be cast and simulated where section sizes down to 1 mm are combined with thicker sections. In this work the steel alloy 17-4PH will be investigated. This alloy is a common engineering material and is used in cast components today. Another important part of the proposed work is the investigation of the possibility to cast steel alloys which are not commonly cast today. These alloys possess material properties that make the suitable for aerospace applications, but are today only produced as forged components or sheet metal. The above mentioned tasks will be performed in collaboration between the research institutes Swerea SWECAST and FRI, Foundry Research Institute together with the investment cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Process development for productive uses of rejected mussel shells as a calcium source and as inert material' in the context of a Fourth Framework call.

assistant: **Objectives**

The objectives of this research proposal are the determination of the value and optimum level of inclusion of mussel shell meal in breeder and laying hen ration as a Calcium source the development and the standardisation of an applicable system where drying and sterilisation of the mussel shells is done followed by crushing the shell to optimum size. Alternative uses of the crushed mussel shell will be investigated such as for use for soil aeration and drainage and as recycling powder in sea waters as feed to plankton. The development of such process will aid in eliminating a big environmental problem having to do with the rejection of the mussel shells in rubbish hips in mussel growing countries by providing for productive uses of the shells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Bringing into focus the cellular dynamics of the plant growth hormone gibberellin' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

During an organism’s development it must integrate internal and external information. An example in plants, whose development stretches across their lifetime, is the coordination between environmental stimuli and endogenous cues on regulating the key hormone gibberellin (GA). The present challenge is to understand how these diverse signals influence GA levels and how GA signalling leads to diverse GA responses. This challenge is deepened by a fundamental problem in hormone research: the specific responses directed by a given hormone often depend on the cell-type, timing, and amount of hormone accumulation, but hormone concentrations are most often assessed at the organism or tissue level. Our approach, based on a novel optogenetic biosensor, GA Perception Sensor 1 (GPS1), brings the goal of high-resolution quantification of GA in vivo within reach. In plants expressing GPS1, we observe gradients of GA in elongating root and shoot tissues. We now aim to understand how a series of independently tunable enzymatic and transport activities combine to articulate the GA gradients that we observe. We further aim to discover the mechanisms by which endogenous and environmental signals regulate these GA enzymes and transporters. Finally, we aim to understand how one of these signals, light, regulates GA patterns to influence dynamic cell growth and organ behavior. Our overarching goal is a systems level understanding of the signal integration upstream and growth programming downstream of GA. The groundbreaking aspect of this proposal is our focus at the cellular level, and we are uniquely positioned to carry out our multidisciplinary aims involving biosensor engineering, innovative imaging, and multiscale modelling. We anticipate that the discoveries stemming from this project wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'distributed ledger technologies and user-driven automation towards self-SOVEREIGN mobile data access in beyond 5G networks' under Horizon Europe.

assistant: **Concept**

Towards the forthcoming transition to a fully connected world (e.g., Internet of Senses, digital twins), support of connected intelligence requires service advertisement, discovery, negotiation and management that goes beyond the complexity and scalability that existing technologies and subscription-driven MNO processes can handle. In Beyond 5G (B5G) networks, cyber-physical assets and intelligent end points will be capable of translating current service requirements to comprehensive technical specifications dynamically (e.g., QoS/QoE management per service chunk) as well as request for full customization of their service terms in line with current availability of tenants/resources and their application requirements. Distributed ledger technologies (DLTs) hold the key for natively disintermediated, cost-efficient, and anonymous B5G communications, enabling transparency and trust to be established across the integrated DLT, radio access and core network continuum. The SOVEREIGN research programme aims to fuel artificial intelligence (AI) with DLT-backed data in order to innovate the B5G service chain and the B5G protocol stack towards the support of fully decentralized, instantaneous, and anonymous resource trading across the B5G network ecosystem (end terminals, infrastructure, OTT service providers, etc.). SOVEREIGN aims to empower intelligent end points in B5G networks, to gain full control of their identities, connectivity, sessions, service terms, and shared data upon accessing B5G spectrum, antennas, network slices and services. To this end, SOVEREIGN will conceptualize and develop a modular end-to-end service architecture integrating DLT-empowered service provisioning, fully decentralized AAA operations, forward-thinking protocols for self-sovereign identity manag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterizing Underground storage organs For their Archaeological investigation' (CHUFA) targeting Horizon 2020.

assistant: **Abstract**

The aim of this proposal is to stablish a systematic methodology for the study of Underground Storage Organs (USOs), commonly known as roots, tubers or bulbs, creating a digital reference collection database and developing experimental archaeology. By doing this, the CHUFA project will remarkably contribute to the advance in the study of food plants among hunter-gatherer Prehistoric groups. Underground Storage Organs (USOs) are plant structures that store mostly carbohydrates and water and they had a key role in different capital moments of human history. However, they are not always well represented in the archaeological record, due to recovery and methodological constrains. This project will deal with the methodological aspects of USOs analysis. The identification of USOs is based on the detailed description of their anatomical structures: outer features of small-sized tubers, and inner cell organization for smaller fragments, for which till date SEM has been used. However, there are serious limitations when dealing with these remains: very few reference materials available, there is no reference collection for other markers such as use-wear or starches and the SEM observation implies sample coating, hindering the possibility of observing the remains from several angles. The main objectives of this proposal are: a) Application of new methods to study parenchymatous tissue remains (ESEM, 3Dscanner and microCT), b) Creation and publication of a botanical reference collection of USOs using the new methods and c) Creation of a data base on use-wear traces and residues on experimental material related to USOs labour. Through its interdisciplinary approach this project will provide archaeobotanists and use-wear analysis specialists with reference material for the identifica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Artificial cell-cell interactions for light switchable cell organization and signaling' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The bottom-up assembly of tissue from cellular building blocks constitutes a promising, yet highly challenging approach to engineer complex tissues. The challenge lies in controlling cell-cell interactions, which determine how cells organize with respect to each other, how they work together and consequently whether such a multicellular architecture will be functional. The limited spatial and temporal control over cell-cell interactions current biological and chemical approaches provide severely restricts bottom-up tissue engineering. Here, I propose a new way to control cell-cell interactions. I aim to regulate cell-cell interactions with visible light using proteins that reversibly homo- or heterodimerize under blue or red light. These photoswitchable cell-cell interactions provide sustainable, non-invasive, dynamic and reversible control over cell-cell interactions with unprecedented spatial and temporal resolution. First of all, we will focus on various light dependent protein interactions to mediate cell-cell contacts. The detailed characterization (strength, dynamics, interaction modes and orthogonality) of these new photoswitchable cell-cell interactions will provide the framework for the bottom-up construction of tissue-like structures. Secondly, we will use these photoswitchable cell-cell interactions to assemble cells into multicellular architectures with predictable and programmable organization. The dynamic and reversible nature of the photoswitchable contacts will allow us to locally alter interactions at any point in time, to rearrange and obtain asymmetric multicellular structures, which are typical of tissues. Finally, we will also explore how the photoswitchable cell-cell interactions alter cell behavior and signaling. Ultimately, this will pave the way
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Screening for Chronic Kidney Disease (CKD)  among Older People across Europe (SCOPE)' under Horizon 2020.

assistant: **Concept**

Chronic kidney disease (CKD) is an important public health problem worldwide, especially in older people. Indeed, population aging in industrialized countries is accompanied by an increase in the prevalence of CKD and its complications. Although its prevalence and the importance of an early diagnosis to prevent complications such as end-renal stage disease (ESRD), screening programme in Europe are highly heterogeneous, fragmented, being in most cases based on opportunistic rather than structured assessments of patients. The main objective of the SCOPE project is to evaluate a large scale screening programme for CKD in the older population (age 75+) in Europe. Specific objectives are (i) to assess existing methodologies to screen for CKD among older adults, including the use of Comprehensive Geriatric Assessments (CGA); (ii) to investigate innovative biomarkers potentially useful for CKD screening; (iii) to evaluate the cost-effectiveness of CKD screening in a population at high risk of kidney function decline and ESRD; (iv) to provide evidence for further development of European recommendations, as well as an education programme in this field. This will be achieved also thanks to the creation of a large observational database including a cohort of older people aged 75 years or more, enrolled within the framework of an observational, multinational, multicenter, prospective study with a 2-year follow up. The SCOPE database will include a CGA-based screening and a collection of biological samples at baseline and at regular intervals during the study.The SCOPE project will provide evidence for the increased use, or discontinuation of, existing screening and prevention programmes in the field of CKD, allowing informed decisions by policymakers. It will contribute to capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improved diagnosis of cancer patients by novel dualistic histology methods' (2002-2006).

assistant: **Innovation**

Pharmacogenomics is an emerging discipline with a great potential for improving future clinical care. The linkage between the knowledge of treatment outcome and the underlying molecular alteration constitutes the principle of pharmacogenomics. The recent d evelopments of Herceptin (targeting the HER2 oncoprotein in breast cancer) and Glivec (targeting the BCR-ABL translocation in leukaemia) have demonstrated a close relationship between the molecular alteration and the clinical response. The success of these treatments has depended absolutely upon the development of appropriate clinical diagnostic tests (pharmacodiagnostics) to identify those patients, who are most likely to benefit from the treatment. The main objective of the proposed industry-academia part nership is to develop newpharmacodiagnostics to improve the selection of patients for targeted cancer therapies. DakoCytomation is a company at the forefront of the development of pharmacodiagnostics as evidenced by their strong involvement in ER and HER2. Dr. Bartlett research group at Glasgow University has achieved a unique expert position by combining translational research with histopathological evaluation of novel targeted cancer therapies tested by the pharmaceutical industry in European clinical tri als. Through exchange of experienced researchers, it is the intention to extend substantially the existing collaboration between DakoCytomation and Dr. Bartlett research group. This efficient way of combining complementary skills makes the objective very r ealistic. The new pharmacodiagnostic assays will be based on a) combining and optimising existing detection principles, b) combining detection of existing and/or novel markers on the same specimens and c) identifying new diseases/therapy indications for ex ist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of pathways and genetic drivers for childhood epileptic encephalopathies by integrating whole-exome sequencing and gene network approaches' in the context of a Seventh Framework call.

assistant: **Objectives**

The objective of the iGENEE project (Integrated Genetic Networks for Epileptic Encephalopathies) is the identification of pathways and genetic drivers for childhood epileptic encephalopathies (EE) by integrating whole-exome sequencing and gene network approaches. It will be supervised by Dr Petretto, Head of the Integrative Genomics and Medicine Group at the MRC Institute of Clinical Sciences, and co-supervised by Dr Johnson, Deputy Head of the Centre for Clinical Translation of Brain Sciences and member of the Epi4K Consortium, both at Imperial College London. I will analyse exome-sequence data generated by the Epi4K/EPGP Consortium in patients with classical EE (n=264 probands) and their parents. Initial analyses identified Sanger-confirmed de novo Single Nucleotide Variants (SNV) in 9.5% of EE probands (Epi4K Consortium et al. Nature, 2013), but further analyses indicated that an additional 90 EE genes are present among the remaining 304 Sanger confirmed de novo SNVs in this patient cohort. To identify these causal mutations and the underlying convergent pathways for EE, I will utilize an integrated systems-level network approach as follows: (1) build gene co-expression networks from human and rodent brain transcriptomes to identify differentially expressed networks from various brain regions and at different stages of brain development; (2) connect gene networks to EE, by testing for enrichment of mutations using the Epi4K exome-sequence data; (3) investigate candidate networks enriched for EE susceptibility variants, by testing if the mutations disrupt the network at a protein-protein interaction level; (4) map key regulatory genes of the EE-associated co-expression networks, using Bayesian methods developed in Dr Petretto’s lab and (5) perform functional validatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Active and Driven Systems: Nonequilibrium Statistical Physics' under Horizon 2020.

assistant: **Concept**

Active Matter systems, such as self-propelled colloids, violate time-reversal symmetry by producing entropy locally, typically converting fuel into mechanical motion at the particle scale. Other driven systems instead produce entropy because of global forcing by external fields, or boundary conditions that impose macroscopic fluxes (such as the momentum flux across a fluid sheared between moving parallel walls). Nonequilibrium statistical physics (NeSP) is the basic toolbox for both classes of system. In recent years, much progress in NeSP has stemmed from bottom-up work on driven systems. This has provided a number of exactly solved benchmark models, and extended approximation techniques to address driven non-ergodic systems, such as sheared glasses. Meanwhile, work on fluctuation theorems and stochastic thermodynamics have created profound, model-independent insights into dynamics far from equilibrium. More recently, the field of Active Matter has moved forward rapidly, leaving in its wake a series of generic and profound NeSP questions that now need answers:  When is time-reversal symmetry, broken at the microscale, restored by coarse-graining? If it is restored, is an effective thermodynamic description is possible? How different is an active system's behaviour from a globally forced one? ADSNeSP aims to distil from recent Active Matter research such fundamental questions; answer them first in the context of specific models and second in more general terms; and then, using the tools and insights gained, shed new light on longstanding problems in the wider class of driven systems.I believe these new tools and insights will be substantial, because local activity takes systems far from equilibrium in a conceptually distinct direction from most types of global driving.