RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Genetic View of Influenza Infection' (GV-FLU) targeting Horizon 2020.

assistant: **Abstract**

Inherited variation in the quantity and functionality of immune cells plays a key role in determining phenotypic diversity between individuals. Surprisingly little is known, however, about the specific contribution of immune cell subsets to variation in phenotypes such as susceptibility to infectious diseases and the underlying genetic variation. In many complex diseases, we currently have a poor understanding of the driver cell types that are responsible for inherited variation in disease states. A comprehensive mapping of quantities and functions of immune cell types during the course of disease, in large cohorts, bears the potential to transform genetic research; provides understanding of the genetic and immune basis of phenotypes; and reveals the key driver cell subsets. Here I aim to derive a mechanistic understanding of how variation in quantity and function of immune cell subsets mediates inherited variation in disease states. I propose to develop a computational model that integrates predicted quantities and functions of cell subsets with genotypic and phenotypic information, leading to specific hypotheses on physiological regulation and the particular cell subsets that drive phenotypic diversity. To circumvent the technical difficulty in quantifying a large number of immune cell types, I will profile gene expression and computationally quantify changes in a large number of cell types. I will develop and apply this strategy to dissect Influenza infection in mice.Since changes in immune responses play a key role in complex diseases, our ability to predict variation in immune responses from genotypes would have important clinical implications. This project has far reaching implications as the paradigm developed here will transform quantitative genetics studies as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Atlantic Ocean Research Alliance Support Action'.

assistant: **Concept**

The Atlantic Ocean Research Alliance Coordination and Support Action (AORAC-SA) is designed to provide scientific, technical and logistical support to the European Commission in developing and implementing trans-Atlantic Marine Research Cooperation between the European Union, the United States of America and Canada. The Coordination and Support Action (CSA) is carried out within the framework of the Atlantic Ocean Research Alliance as outlined in the Galway Statement on Atlantic Ocean Cooperation (May 2013).  Recognising the evolving nature of the Atlantic Ocean Research Alliance, the hallmark of this proposal is that it is flexible, responsive, inclusive, efficient, innovative, value-adding and supportive. To support the Commission in negotiations with the USA and Canada on trans-Atlantic Ocean Research Cooperation, the AORAC-SA support and governance structure comprises a Secretariat and Management Team, guided by a high-level Operational Board, representative of the major European Marine Research Programming and Funding Organisations as well as those of the USA and Canada. This structure is further able to draw on significant marine research expertise and experience through its partner organisations The CSA, reporting to the Commission representatives of the Atlantic Ocean Research Alliance, will be responsible for the organisation of expert and stakeholder meetings, workshops and conferences required by the Atlantic Ocean Research Alliance and related to identified research priorities (e.g. marine ecosystem-approach, observing systems, marine biotechnology, aquaculture, ocean literacy, seabed and benthic habitat mapping), support actions (e.g. shared access to infrastructure, dissemination and knowledge transfer, establishment of a knowledge sharing platform) and ot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Large-Scale Computational Screening and Design of Highly-ordered pi-conjugated Molecular Precursors to Organic Electronic'.

assistant: **Concept**

The field of electronics has been a veritable powerhouse of the economy, driving technological breakthroughs that affect all aspects of everyday life. Aside from silicon, there has been growing interest in developing a novel generation of electronic devices based on pi-conjugated polymers and oligomers. While their goal is not to exceed the performance of silicon technologies, they could enable far reduced fabrication costs as well as completely new functionalities (e.g. mechanical flexibility, transparency, impact resistance). The performance of these organic devices is greatly dependent on the organization and electronic structures of π-conjugated polymer chains at the molecular level. To achieve full potential, technological developments require fine-tuning of the relative orientation/position of the pi-conjugated moieties, which provide a practical means to enhance electronic properties. The discovery pace of novel materials can be accelerated considerably by the development of efficient computational schemes. This requires an integrated approach, based on which the structural, electronic, and charge transport properties of novel molecular candidates are evaluated computationally and predictions benchmarked by proof of principle experiments. This research program aims at developing a threefold computational screening strategy enabling the design of an emerging class of molecular precursors based on the insertion of π-conjugated molecules into self-assembled hydrogen bond aggregator segments (e.g. oligopeptide, nucleotide and carbohydrate motifs). These bioinspired functionalized pi-conjugated systems offer the highly desirable prospect of achieving ordered suprastructures abundant in nature with the enhanced functionalities only observed in synthetic polymers. A mor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '‘Leaving something behind’ - Migration governance and agricultural & rural change in ‘home’ communities: comparative experience from Europe, Asia and Africa' in the context of a Horizon 2020 call.

assistant: **Objectives**

AGRUMIG proposes an integrated approach to migration governance to address the two way relationship between labour mobilility and changes in agriculture and the rural sector. Migration creates challenges for rural ‘sending’ communities in low and middle income countries, yet it can also be transformative.  AGRUMIG aims to engage in a comparative analysis of seven countries to analyse the economic, institutional, cultural and agro-ecological factors which shape these relationships. It will go on to identify the range of governance interventions which can harness migration to stimulate sustainable and gender equitable growth in agriculture and reduce the distress associated with migration.   The project will firstly use a survey and participatory tools to explore the drivers of migration and the impacts on the agricultural/rural sector. A Qualitative Comparative Analysis will identify contexts through which unique relationships are realised. It will secondly engage with the policies and practices of diverse governance actors through dialogue, literature reviews and interviews to understand how they mediate the migration-agrarian/rural change interface. It will thirdly, engage in an iterative process of dialogue with stakeholders to identify frameworks for integrated migration governance which harness the positive impacts.  A key contribution to the work programme is the identification of strategies to promote safe and regular migration through supporting change in sending regions. AGRUMIG will outline longer term evidence based governance solutions, supported by comparative analysis and tangible indicators, which are sensitive to the role of migration in larger livelihood systems as well as the contexts through which favourable impacts can be captured. It will analyse exi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fast and novel manufacturing technologies for thin multicrystalline silicon solar cells - (FANTASI)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Objectives:As stated in the 5th FWP, the cost targets for PV systems are 7 and 3 Euro/Wp for the short and medium term, respectively. The aim for the PV module cost is < 1 Euro/Wp by 2010, helping to reach the White Paper target of 3 GWp capacity by 2010. These issues are addressed by the objectives of this proposal. The basic project aim is a significant reduction of the manufacturing cost/Wp by the development of innovative cell structures and related fast (>1dm²/3s) low-stress manufacturing technologies suitable for thin (200 micrometer) EFG Si sheets and multicrystalline Si wafers, leading to efficiencies of 15.0% (EFG) and 16.5% (multi-Si) and a reduction of expensive Si-feedstock consumption to values below 4 gr. Si/Wp. The feasibility of cost reduction has to be validated at the end of the project by verification of the assumptions in the MUSIC -FM study (CT94 0008).Work performed:In parallel three alternative texturing processes have been developed. Two of these processes result in an isotropically textured surface. These processes rely on acidic etching solutions. The first texturing process is only suited for multicrystalline wafers that are diced from an ingot because the etching mechanism relies on the saw damage from wafer dicing. Because this process is not suited for EFG Si wafers (no saw damage present) another chemical solution has been developed for EFG wafers. A third texturing technology is based on an alkaline texturing set-up that applies a high cathodic potential by attaching an electrode to the wafer. Thus short-etching times can be achieved and the regime of alkaline etching can be varied in a wide range. While the first two technologies have been successfully applied to the production of solar cells, the third alternative is still on a more fun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A unique innovative utility scale solar energy technology that utilises a field of low cost heliostat collectors to concentrate sunlight onto an ultra-efficient multi-junction photovoltaic cell array' (RAYGEN) targeting Horizon 2020.

assistant: **Abstract**

Current utility PV installations require a large quantity of PV panels (semiconductors), space (land resources) and are consequently very capital intensive.      RayGen offers a proprietary breakthrough utility scale solar energy technology that utilises a field of low cost heliostat collectors to concentrate sunlight onto an ultra-efficient multi-junction photovoltaic cell array located in a mast mounted central receiver. The technology combines the benefits of traditional PV with solar thermal energy installations and leverages several patents and trade secrets.The RayGen CSPV offers unique value to Energy Utility Companies and System integrators, such as 40% less collector area than CPV as well as 65% plant mass, performance 2.4x higher than conventional PV plants with only 0.1% of PV cells, cheaper and easier installation and maintenance, high reliability and most importantly capital expenditure 95% less than traditional PV. RayGen’s technology is also the leader in PV performance, since it presently holds (with the University of New South Wales, Australia) the world record solar system efficiency of 40.4%, independently verified by NREL.The technology has been validated with extensive lab tests and the Australian mother company is already testing the design in a pilot plant in Bridgewater Australia, supported by the Australian Government. The Phase 1 project will be focused on establishing a complete supply chain, a sound business model and commercialization strategy and to plan all activities for deploying a large scale pilot supported by a major energy utility company and partnering system integrator SMEs Nur Energie Ltd, Cautha Srl and Renience Srl.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'GIANT REED (ARUNDO DONAX L.) NETWORK. IMPROVEMENT, PRODUCTIVITY AND BIOMASS QUALITY' in the context of a Fourth Framework call.

assistant: **Objectives**

Giant reed (Arundo donax L.) is a potentially high yielding non-food crop that could meet EU market requirements for energy, paper pulp production and construction of building materials. It has the advantage of being a native of south-eastern Europe and therefore naturally adapted to EU agro-climatic conditions. Certain unimproved populations achieved dry matter yields up to 40 tons/ha. Giant reed is also one of the most cost effective crop, environmentally friendly and presents large prospect by selection and improvement, to become the champion of biomass crops.However, giant reed has never been domesticated because of the absence of any market.The ultimate objective of the proposed project is the introduction of giant reed, a high-yielding, non-food plant, into EU agriculture.The specific objectives of the proposed project are:* To determine the suitability of giant reed as a new non-food crop (for energy, paper and construction of building materials) within EU agriculture by evaluating a wide range of native populations in Greece and Italy. *To establish the limitations to production in the EU by quantifying and biomass productivity of selected populations in Northern and Western EU environmental conditions (Germany, UK, France, Spain).* To develop a growth and biomass productivity model for giant reed by determining growth, biomass yields and quality under contrasting EU conditions (with particular emphasis on the Mediterranean basin but in comparison with northern and western regions).* To determine the most successful and cost-effective methods of establishment by evaluation of various propagation techniques (micropropagation, rhizomes, stem cuttings).* To identify the most appropriate agronomic practices for maximizing biomass yields by assessing the effects of i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Optical Gravitational Lensing Experiment: New Frontiers in Observational Astronomy' (OGLEIV).

assistant: **Innovation**

We apply for financial support for the new, fourth phase of the Optical Gravitational Lensing Experiment (OGLE-IV) - one of the largest scale sky surveys worldwide, operating continuously since 1992. During its operation the OGLE project contributed significantly to many fields of modern astrophysics including gravitational microlensing, extrasolar planets searches, stellar astrophysics, Galactic structure and many others. The main scientific goal of the OGLE-IV phase will be the second generation planetary microlensing survey. It should result in top rank discoveries of the Earth mass planets and should provide the full census of planets down to Earth masses orbiting their hosts at 1-5 AU orbits. This parameter space is only accessible to the microlensing technique. Complementary census of planets orbiting at the distances smaller that 1 AU is to be made by space missions using transit technique.  OGLE-IV survey will also conduct research in many other top rank astrophysical topics like the search for Pluto size dwarf planets from the Kuiper Belt, search for free-floating black holes, microlensing in the Magellanic Clouds and Galactic disk. Hundreds of new discoveries in the variable star field are also guaranteed. Moreover, OGLE-IV will operate on-line services providing real time photometry of variable objects of many types. The OGLE-IV data will be placed in public domain and available to the astronomical community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Predicting antibiotic resistance' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of this proposal is to describe and predict the dynamics of antibiotic resistance development at the level of the drug target, the microbe and the host. That is, we want to generate the knowledge required to be able to connect resistance mechanism --> bacterial physiology and fitness --> bacterial survival within a host --> bacterial spread between hosts. To achieve this goal we will develop quantitative models that can capture these complex dynamics, obtain relevant parameter values and validate the models by testing them in suitable in vitro, animal models and in clinical settings. We will address three main areas (A-C) in 11 different work packages. A. Formation and emergence of resistant bacteria (WPs1-5). The rate of formation of resistant mutants is one major determinant that influences how rapidly resistant mutants will appear in response to antibiotic use. Depending on the type of resistance mechanism factors such as rates of mutation, recombination and transfer of plasmids will be important. In WPs 1-5 we will experimentally determine these rates for different combinations of bacterial species and resistance mechanisms. B. Survival and persistence of resistant strains (WPs 6-8). A key factor that affects the survival and persistence of resistant strains is the impact the particular resistance mechanism has on bacterial physiology, including bacterial growth rate and virulence. We want to determine the effect of various drug resistance mechanisms on cellular physiology and fitness to establish a link between the molecular alteration and potential effects at the cellular level. C. Transmission of resistant strains (WPs 9-11). Finally we want to understand and predict how resistance mechanisms (by their effect on bacterial physiology) influence the ability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biodegradable Magnetic Stent for Coronary Artery Luminal Regeneration' (BIOMAGSCAR).

assistant: **Concept**

By 2010 1.5 million stents per year will be deployed in Europe. Although outcome for patients has improved, stents still fail because of the occurrence of restenosis and thrombosis at the site of implantation. While drug eluting stents have helped to reduce the problem of restenosis, neointimal proliferation causing restenosis can still occur. Additional concerns exist regarding drug eluting stents as there appears to be a small but real increase in late and very late stent thrombosis, particularly after discontinuation of antiplatelet therapy.The novel concept we propose is use of a biodegradable magnetised stent (BMS) to deliver a novel biological therapy offering regenerative medicine solutions to the coronary artery vessel wall. Specifically we will develop the stent technology as a platform to attract autologous progenitor cells tagged in vitro with iron nanoparticles. Once deployed, the cells will be attracted to the already implanted BMS and proliferate to form a new endothelium. We will also use over-expression of the NRP1 gene in the artery wall where it will dimerise with NRP1 receptors on the deployed cells. The NRP1 gene will be transfected by adenovirus delivered from the wall of the BMS. Over time the BMS will undergo a predictable degradation to leave a wholly biological artery through regeneration of native tissues.Currently, about 12,000 European Citizens a year suffer from late in-stent thrombosis and 120,000 from restenosis. With the knowledge and technologies developed through the BIOMAGSCAR project we aim to halve this number of patients and save 66,000 people from unnecessary suffering, saving the European healthcare system €275 million p.a. in direct costs, only 10% of the total associated costs.Our consortium includes a vascular disease therapy c