RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cancer heterogeneity and therapy profiling using bioresponsive nanohydrogels for the delivery of multicolor logic genetic circuits.'.

assistant: **Objectives**

Conventional cancer therapies suffer from poor efficacy owing to the lack of efficient delivery systems and to the inherent tumor heterogeneity that requires multi-modal approach to abrogate cancer progression. Nanotechnology holds promise to address these drawbacks, as the use of (bio)nanomaterials for diagnostics and therapy has been gaining momentum over the last years. The main goal of this project is to develop a novel and facile platform capable of profiling both the therapy outcome and heterogeneity in cancer, by using bioresponsive nanohydrogels for the delivery of logic multicolor synthetic gene circuits. These logic synthetic gene circuits will be designed as a biobarcode of multicolor RNA circuits embedded in hybrid nanoparticles and doped in hydrogels for local therapy in breast cancer in vivo. Using cell-type specific promoters, the multicolor miRNA circuits will be expressed specifically to each type of the cells of the tumor microenvironment. Subsequently, this will permit to evaluate the therapeutic efficacy in a cell-by-cell basis and to profile the tumor heterogeneity across different breast cancer types. In order to potentiate the translation of this ground-breaking platform into clinics and precision medicine, novel de-regulated miRNA targets will be identified based on screens performed in breast cancer patient-derived tumors that better reflect the heterogeneous tumor microenvironment in a patient-by-patient basis. In sum, the material platforms developed herein and newly identified biological targets can be harnessed to design effective cancer treatments that go beyond breast cancer. The project is highly versatile and multidisciplinary and this system can be easily adapted to target any cancer cell type and molecular mechanisms and translated to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Silicon and T2SL EuroPean collaboration for a non-dependent supply chain for large eSWIR FPAs'.

assistant: **Innovation**

In the last years, Mercury Cadmium Telluride (MCT) IR Focal Plane Arrays (FPAs) have drastically boosted the observational capabilities of space IR payloads. In the US, industrial production of MCT IR FPAs with formats up to 4K×4K pixels is established, while in Europe, initiatives from European Institutions and most advanced EU manufacturers are currently on-going to progress on large format MCT hybrids such as 2kx2k, though the industrial set-up necessary to support operational space programs remains to be elaborated and matured. As instruments designers are asking for larger size FPAs, EU detector manufacturers are losing ground with respect to US competitors.T2SL technology is an alternative to MCT for the manufacturing of IR FPAs. In the US, progress on T2SL FPA development led to up to 8K×8K IR FPAs demonstrations, but like US MCT ones, these are not easily available for the EU market due to strong export/ITAR restrictions. Moreover, US ROICs feature better performances and interfaces compared to their EU counterparts.The STEP project will provide a disruptive European supply chain fully focused on the design and manufacturing of competitive and affordable large format T2SL eSWIR FPAs. STEP will incorporate all steps of the IR FPA production chain: detector design, large scale growth, fabrication, hybridization, large format and high performances scalable ROIC with dedicated features to improve eSWIR space FPA performances, and evaluation of large space prototype FPAs (including space environment evaluation).STEP will benefit from a European complementary consortium team: Airbus, the well-known space industrial (requirements, performances testing, environment evaluation, space missions insertion and business plan), the European leader in T2SL manufacturing, IRnova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systems Chemical Biology - Chemical Biological Perturbation and Dissection of Dynamic Biological Systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In Systems Chemical Biology research small drug-like molecules are employed to analyze the construction, wiring and spatiotemporal regulation of protein networks in dynamic biological systems. They act fast, reversibly, conditional, do not alter network architecture and need to be biologically relevant, a property particularly given for the scaffolds of natural product classes chosen in evolution to interact with proteins and to modulate dynamic biological systems.In the research project novel cheminformatic methods will be developed to analyse all known natural products and additional biologically relevant compound classes and to identify natural product fragments in order to guide the synthesis of natural product-inspired compound collections each of ca. 500-1000 members with high scaffold diversity (in particular indoles, spirooxidoles, tetrahydropyrans, iridoids, lactones, hybrid natural products). The synthesis will include the development of novel organic synthesis methodology with a special emphasis on enantioselective catalysis and multi-step Domino sequences. The compound collection will be screened in unbiased phenotypic assays monitoring mitosis and dynamic signal transduction pathways. The patterns of cellular targets of hit compounds will be identified and validated by means of chemical proteomics, biochemistry, biophysics and cell biology investigations, and novel chemical probes for the study of dynamic biological processes and systems will be devised.Systems Chemical Biology research will have a major impact on basic science by opening up unprecedented opportunities for the study of dynamic biological systems enabling breakthrough discoveries, and it will create a novel systematic means to identify drug candidates that target multiple proteins.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Mechatronics for a new generation of production systems' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The goal of EUMECHA-PRO is to increase the ability of the European mechatronics research community to conceive - according to a common strategy and in strong cooperation with industry - the production systems for the factories of the future. EUMECHA-PRO w ill develop industry roadmaps and research roadmaps. The industry roadmaps will provide a structured view on future industrial expectations and will be established for different production equipment sectors. Research roadmaps will reflect the visions and capabilities of the European mechatronics research community. The research and industry roadmaps will be integrated into a common vision. The emerging technologies and integrated design approaches in the research roadmaps will be associated to industry' s requirements and will reveal new industrial opportunities. On the other hand, the industrial expectations will orient research towards market needs. The research roadmaps will furthermore provide a common framework for an efficient co-ordination of Euro pe's research resources. EUMECHA-PRO will promote the practice of the mechatronics design paradigm in industry. Best practices of mechatronic design will be identified and promoted through industry-oriented workshops. EUMECHA-PRO will strive towards a better educational framework that delivers excellent mechatronic engineers to the manufacturing industries. Mechatronics education requirements and approaches will be analysed, resulting in a European vision on how education can be improved and be made mor e coherent across Europe. Dissemination and exchange of information will take place through internet, publications as well as through small committee network meetings. Furthermore, EUMECHA-PRO will improve the coordination of various R&D funding mec hanisms, in particul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Extracellular vesicles: novel compartments for cAMP signaling'.

assistant: **Innovation**

Cyclic AMP (cAMP) is a pivotal secondary messenger that orchestrates a vast range of physiological processes by translating signals from hormones, neurotransmitters, and growth factors. While the intracellular roles of cAMP are well understood, its functions outside the cell remain largely unexplored. The EVOCAMP project seeks to uncover this hidden dimension by exploring how extracellular vesicles (EVs) mediate intercellular cAMP signaling. EVs, a heterogenous group of membrane-bound vesicles, have emerged as key mediators of intercellular communication. This project aims to establish EVs as novel compartments for intercellular cAMP signaling and to elucidate their functional significance in the brain. To achieve this, the project is structured around three objectives: First, to demonstrate that neuron-derived EVs are capable of synthesizing and releasing cAMP into the extracellular space, thereby functioning as novel platforms for cAMP signaling. Second, to map the downstream signaling events triggered by these cAMP-producing EVs in recipient cells, using advanced biosensors to monitor these signaling pathways. Third, to investigate the physiological relevance of cAMP-producing EVs in vivo, using zebrafish embryos to visualize their dynamics, trace their fate, and assess their functions in living organisms. By uncovering a previously overlooked aspect of cAMP signaling, EVOCAMP will reveal a novel mechanism of intercellular communication driven by EVs with significant implications for brain physiology. Furthermore, the skills and knowledge gained through this project will be pivotal in my development as an independent researcher, positioning me at the forefront of interdisciplinary research between cell signaling and extracellular vesicle biology.


**Keywords:** cycl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a Novel Integrated Inspection System for the Accurate Evaluation of the Structural Integrity of Rail Tracks' (INTERAIL) targeting Seventh Framework.

assistant: **Abstract**

The European rail industry is showing signs of steady recovery after a long period of decline. The technological advances in train design have led to the manufacturing of faster, greener and more comfortable trains making rail transport a more attractive option for passengers in comparison with other means of transportation. The ever growing need for the society to employ more environmentally friendly transportation policies is expected to further underline the economic and societal role of rail transport in achieving sustainable mobility across Europe in the years to follow. The European rail network is continuously getting busier with trains travelling at higher speeds and carrying more passengers and heavier axle loads than ever before. The combination of these factors has put considerable pressure on the existing infrastructure leading to increased demands in inspection and maintenance of rail assets. The expenditure for inspection and maintenance has thus grown over the last few years without however being followed by a significant improvement of the industry’s safety records. A large proportion of all infrastructure related accidents in the rail industry is due to rail failure. The continuous increase in train traffic, axle loads and speeds means that the failure of a rail section may result in very serious derailments, such as the one that took place in Hatfield, UK, in 2000, causing loss of life, injuries, severe disruption in the operation of the network, unnecessary costs, and loss of confidence in rail transport by the general public. INTERAIL seeks to practically eliminate rail failures by developing and successfully implementing an integrated high-speed system for the fast and reliable inspection of rail tracks. The application of the high-speed system will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Insider Threat Management for Critical Infrastructure Cyber-security: A Three-party Game-Theoretic Perspective' under Horizon Europe.

assistant: **Concept**

Dr Gehui Xu will carry out a project focusing on Insider Threat Management for Critical Infrastructure Cyber-security: A Three-party Game-Theoretic Perspective (INSIDER). The impact of insider threats on cyber-security will be studied from a game-theoretic perspective, and effective defense strategies will be developed to identify, assess, and mitigate complex internal-external coordinated attacks. The established theoretical framework will be applied to microgrids, a crucial component of critical infrastructure, providing valuable insights into their security enhancement. This approach aims to establish a close connection between cyber-security and game theory. The project will be carried out with the Control and Power (CAP) Research Group, Department of Electrical and Electronic Engineering (EEE), Imperial College London (ICL), under the supervision of Prof. Thomas Parisini. As a part of the project, a 3-month secondment will be carried out at the KIOS Research and Innovation Center of Excellence (KIOS CoE), University of Cyprus (UCY).


**Keywords:** Game theory,  Cyber-security, Insider threat, Mechanism design, Microgrid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'TAG CLOUD Technologies lead to Adaptability & lifelong enGagement with culture throughout the CLOUD' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cultural heritage is an important asset of Europe which is largely underexplored. One of the main reasons is that the general public do not really incorporate cultural activities in their life style. Currently, cultural heritage institutions attempt to attract, engage and retain visitors using a range of digital technologies from relatively cheap interactive websites to expensive on-site 3D visualisations. Despite the employment of these technologies the success of significantly increasing their visitor base has been limited. A major drawback of the current approach is that information about a cultural object, which these technologies convey to the users, is still centrally" produced by experts (e.g. curators, historians, archaeologists, etc.). Moreover, personalised interactive systems are also centrally defined and based on general views about the background and preferences of the general population.<br/>TAG CLOUD offers a radically new approach in developing truly personalised cultural experiences by seamlessly incorporating cloud-based (non-sensitive) information about the habits, preferences and motives of individuals into the digital content of a cultural objects (e.g. artefacts, buildings, sites, etc.) and allowing to increase the users' interest for cultural heritage giving an active participation in the assignment of the importance of a cultural artefact, becoming participants in the creation of their own cultural experiences, creating, sharing, and adding information within social media. TAG CLOUD plans to add new meaning to cultural digital content by producing adaptive cultural contents based on fusion of expert and visitor information.<br/>The methodology and interactive technologies, which will be developed in TAG CLOUD, will result in introducing more peo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Replicating the rain process to provide a sustainable drinking water supply where most needed' (STRATUS), addressing dissemination and exploitation.

assistant: **Impact**

GENAQ is a Spanish SME focused on the development and commercialisation of disruptive Atmospheric Water Generators (AWGs). With a consolidated team of 6 engineers, developers and market experts our aim is to become the global standard in AWG technology. Bottled water is the most popular solution to supply drinking water to areas where water is scarce or lacks sufficient quality. However, it is expensive, generates large amounts of plastic waste and results in multiple impacts associated to its production and transportation. Current alternatives to bottled water such as water filters and water tanks also face several limitations (need of a water source, insufficient water quality). AWGs generate drinking water by condensing ambient humidity, avoiding the generation of residues or transportation impacts. Nevertheless, available AWGs are expensive, have low efficiency and are poorly suited for their installation in residential or commercial premises. The global AWGs market is expected to grow at a booming 30% CAGR, reaching over €7 bn by 2025, creating a unique opportunity for the introduction of affordable, efficient and functional AWGs. STRATUS is the next AWG series in GENAQ’s pipeline. Targeting residential, commercial and public premises, STRATUS models (with 20, 50 and 200l/day capacity) produce top quality drinking water, achieving 50% higher water production and 150% reduced energy consumption compared to available AWGs while offering a 1-year payback period and a user-friendly interface. Moreover, STRATUS contributes to maintain optimum ambient humidity and generates hot water without consuming additional energy. STRATUS has reached TRL7 through the successful implementation of larger models for remote locations and emergency response purposes (NIMBUS and CUMULUS)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Standard Operating Procedures for Research Integrity' (SOPs4RI) under Horizon 2020.

assistant: **Objectives**

The objective of the Standard Operating Procedures for Research Integrity (SOPs4RI) project is to promote excellent research that aligns with the principles and norms of the European Code of Conduct for Research Integrity, and to counter research misconduct. SOPs4RI will stimulate transformational processes across European research performing organisations (RPOs) and research funding organisations (RFOs) to achieve  this goal. SOPs4RI involves a mixed-methods, co-creative approach to the development and empirical validation of standard operating procedures (SOPs) and guidelines to cultivate research integrity and reduce detrimental practices.  With rigorous methods, the SOPs and guidelines will be developed by experts and key stakeholders and will be offered as flexible tools for RPOs and RFOs to develop Research Integrity Promotion Plans. Active researchers in the EU and selected OECD countries will be surveyed as part of the validation procedure. Proposals for appropriate incentives and novel sanctions will be developed to promote adoption. The discipline-sensitive SOPs and guidelines will support the production of sound, trust-worthy knowledge, a precondition for tackling the current crisis of truth and trust in science. In turn, a strong research integrity culture and high epistemic quality of research-based knowledge will make a vital contribution to addressing the EU’s current and future challenges. SOPs4RI is fully aligned with the core objectives of the Science with and for Society 2018-20 Work Programme and will draw upon and liaise with other projects in the work programme. To maximise the feasibility and impact of the project’s outcomes, SOPs4RI engages with key stakeholders in the ERA and beyond in an iterative development, cost benefit assessment, and real