RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Game-changing uPAR-targeting dye for guiding surgical treatment of cancer' (INSTAGLOW).

assistant: **Concept**

Surgery is a cornerstone in treatment of early cancer, used in 45% of all patients, although cancer commonly recurs after surgery due to incomplete removal. The residual tumour not only leads to avoidable suffering and even dying of patients but also presents a huge financial burden for the healthcare system. As such, there is a major unmet need to accurately delineate tumour from healthy tissue, identify local metastases, and aid surgeons to precisely remove the entire tumour. FluoGuide will deliver FG001, a breakthrough, real-time, surgical visualisation solution that lights up cancer and improve surgical precision during removal surgery. FG001 is the first active targeting fluorescent tumour marker that targets uPAR, a receptor extensively expressed (95%) in a wide range (>50%) of solid tumours such as brain (glioblastoma; GBM), breast, colorectal, lung and head and neck cancers. FluoGuide’s proprietary FG001 will revolutionise cancer surgery to improve the surgical outcome of >3 million cancer patients undergoing surgery every year.To realise this huge potential, FluoGuide is working on accelerating the development of FG001. Our initial focus is on GBM for which the prognosis is extremely poor with half of all patients dying within 14 months. Moreover, surgery is extremely challenging as removing too much brain tissue can severely disable the patient. FG001 can thus enormously improve surgery of GBM patients. The funding from EIC accelerator pilot will accelerate FG001’s clinical phase IIb/III study for GBM, and catapult FluoGuide to become a leader in cancer surgery guidance. We will generate revenues by 1) direct sales for compassionate use sales (2021) to showcase FG001, 2) direct sales in EU (2023), paid for via reimbursement by insurance companies and governmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'LUnga notte della ricerca - Lange NAcht der Forschung'.

assistant: **Objectives**

The European Academy of Bozen/Bolzano (EURAC), the Free university of Bolzano (FUB) and Techno Innovation South Tyrol (TIS) will jointly organise the Researchers' night 2010 “Long Night of Scientific Research” in Bolzano on September 24, 2010. The project mainly aims at enhancing public recognition of researchers and their work, showing their human face to the public at large, regardless of age or scientific background.As such, it will offer a varied and broad programme of activities addressing both children, teenagers, families, teachers, elderly…and based on a balanced combination n of un and researcher-science linked activities.The activities will take place in the partners' premises, i.e. close to the city centre for two of them and the industrial area in the south of Bolzano for the third one (TIS).They will be implemented with support of industrial and public bodies selected on the basis of an open call by the project's participants:oBolzano local authority: central square events;oPrivate companies in the industrial area: guided tours.Events will take place in easily reachable areas (free shuttle or public means), with students guiding the visitors and coordinating the shuttle; activities will notably include:oInteractive games;oWorkshops;oHands on experiments;oLecturesoExchanges with researchers;oDemos and science shows…oJoint competition with EU funded Trento project…oIllustration of research results and of the European dimension of the event…Activities will last as from 5 p.m. until late in the night.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Three-dimensional solution structure of monomeric superoxide dismutase and its mutants - structure-function correlations' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The three-dimensional structure in solution of a monomeric form of the Cu(II)-Co(II) containing superoxide dismutase (SOD) will be determined by using multidimensional NMR spectroscopy. Previous biophysical studies have shown that residues Arg143 and Thr137, located close to the Cu(II) site, play an important role in the reaction catalyzed by the enzyme. Site-specific mutations at these two positions will be carried out, and the solution structure of these two SOD derivatives will also be determined. Through the detailed comparison and analysis of the changes induced in the structure and dynamics of the active site channel upon mutation, correlations will be established between structure and enzymatic function. Due to the paramagnetism of the protein modifications to the standard NMR methodologies as well as development of new ones will be required in order to acquire a complete sequence-specific signal assignment and thus successfully proceed to the solution structure determination of monomeric CuCoSOD and its mutants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Data-Driven Bioinspired Design of Fatigue Super-Resistant Structures: learning by Nature and Flying into the future' (ButterFly) under Horizon Europe.

assistant: **Objectives**

Biological material science is a new research topic at the interface of biology and physical science, having a common ground in chemistry, physics, mechanics and engineering. During their evolution, biological materials have developed a unique combination of properties to fulfil specific functions through a series of ingenious and distinctive design elements, evident in different systems created by nature. As an example, butterfly wings have an extraordinary combination of lightness, durability and iridescence. We have merely scratched the surface of this knowledge. Exploring the basis of the unique performance of natural and biological materials, a material science perspective has been widely adopted. However, the study of natural systems considering a structural perspective is still at its early stage and, up to now, we have not fully taken advantage of this potentially unique and immense source of design inspiration, especially in the field of structural integrity and fatigue design. ButterFly is aimed to fill this gap in knowledge making a ground-breaking jump towards bioinspired fatigue design. Fatigue is in fact the most ubiquitous mode of fracture accounting for more than 80% of all in service failures in structural components; however, available design approaches are still deterministic and uselessly repetitive. ButterFly will, for the first time, develop a novel and reliable mechanistic approach able to capture the salient design principles allowing long-term durability of natural systems and will transfer this new fundamental knowledge to design fatigue super-resistant structures. Building upon promising results from my research group, I am convinced that ButterFly will induce an utterly new paradigm-shift in fatigue design inspired by Nature with a considerab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Advancing Quantum Computers for (and with) Quantum Thermodynamics'.

assistant: **Innovation**

While thermodynamics is one of the most well-established physical theories, there is much that remains to be worked out in its extension to the quantum realm.  With the miniaturization of electronics down to the nanoscale, along with the emergence of quantum technologies, it is becoming essential to gain a better understanding of thermodynamics at the quantum level.  The emergence of quantum computers (QCs) in the last decade provides a game-changing new tool for research into quantum thermodynamics (QT).  Furthermore, still in nascent stages, QCs stand to gain vast improvements in performance from new insights derived from QT.  An elegant synergy therefore exists whereby (i) QCs can be used to improve the fundamental understanding of QT and (ii) principles from QT may be used to improve the reliability of QCs.  Inspired by this synergy, this proposal includes two thrusts to advance progress along these two fronts.  For the first thrust, I aim to develop new algorithms packaged into well-documented, open-source software for simulating thermal properties and behaviors of quantum systems on QCs.  This work will culminate in attempting the first-ever experimental validation fluctuation relations (theoretical pillars of QT) for open quantum systems on a QC.  For the second thrust I aim to use the principles of QT to implement an algorithmic cooling scheme that can improve the overall performance of qubits for any desired application on a QC.  This work will culminate in attempting the first-ever experimental demonstration of algorithmic cooling on a QC.  The proposed research requires an interdisciplinary approach encompassing quantum information and computation; thermodynamics and statistical mechanics; and computational science (CS).  The complementary expertise and exper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Measurement of the inclusive jet cross section' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

The goal of this proposal is to contribute to the measurement of the inclusive jet cross section in the ATLAS detector at 10TeV using the proton-proton collisions of the LHC. The aim is to profit my experience in the US with jet calibration and bring it to Europe. In addition the wide experience of the CERN scientists in the field will help me to boost my career as a physicist. The work plan is first to focus in the jet trigger efficiencies and to set the global scale using the luminosity provided by the accelerator. The jet scale would be a simple Pt correction with a big uncertainty. In a second phase weighting techniques will be used to optimize the resolution. These are based in the identification of hadronic and electromagnetic depositions and apply weights on an event by event basis to correct the calorimeter non compensation. In each of the two stages the measurement will be compared with the standard model prediction. Finally the last phase is a fine tuning of the whole process using more refined techniques for resolution improvement and better measurement of the luminosity. The measurement of the inclusive jet cross section is a key measurement to understand the parton distribution functions and explore new physics as quark compositeness or extra dimensions while being a background of almost any measurement or search at the LHC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A unique Lead Acid Battery (LAB) recycling technology to reduce CO2 emissions by 89%, reduce waste by 81%, and transform the battery recycling industry' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Lead Acid Batteries (LABs) are a vital and widely-used technology. The global LAB market is expected to grow by 59% to €71.6 billion by 2022 with Europe accounting for the second largest market share.Waste LAB recycling rates are as high as 95% in Europe, but the current recycling process – smelting waste LABs in afurnace – consumes vast quantities of energy, is highly polluting, wasteful, large scale and expensive. Furthermore, smeltedlead must be further processed to produce the essential LAB ingredient: the active lead oxide paste.A new lead recycling process is needed that is energy efficient, non-polluting, low cost, scalable and produces LAB-readylead products. Such process would meet EC priorities by addressing resource efficiency, the sustainable supply of rawmaterials and drive the circular economy.AEL has developed a novel hydrometallurgical process technology to recycle waste LABs in a highly energy efficient, non-polluting and cost effective way. NUOVOpb’s commercial appeal lies in its low cost and scalability, and our ground-breaking ability to produce LAB-ready products that exceed the performance of current products on the market. Our LAB-ready paste can create new LABs with 22% greater energy capacity and 50% longer life. The technology has the potential to transform the global battery recycling industry, which has an expected value of €9.5 billion in 2024.5 years post project, we expect to be operating 18 NUOVOpb facilities across the world. These will be processing 490,000tonnes of waste LABs (6% of the global waste LAB market) and avoiding 196,000 tonnes CO2 emissions every year. In doing so, AEL will secure annual revenues of €206 million, profits of €54 million, and will have created 200 jobs within AEL. NUOVOpb is the most complete closed-loop recy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Self-assembled molecular boxes by quadrupole rosette formation'.

assistant: **Innovation**

Research objectives and content Taking inspiration from nature, one target in supramolecular chemistry is the synthesis of receptors able to recognize guest molecules. The purpose of this project is to prepare molecular receptors by the use of reversible non-covalent assembly. The self-assembly of these molecular boxes will be realized by means of hydrogen bond interactions (72 intermolecular H-bonds) using the double rosette motif. Calix(4)arenes will be used as molecular platforms for the positioning of H-bond donating and accepting groups. Calix(4)arenes also offer ample possibilities for varying the size and shape of the nano-sized cavity, and functional groups on the concave inside. This enables fine-tuning of the binding properties of these receptor molecules for virtually any desired substrate. The project will include: (i) the synthesis of the molecular building blocks, (ii) the assembly studies, (iii) the inclusion studies, and (iv) the preparation of libraries of receptors by mixing building blocks bearing different functional groups. The assembly of these molecular boxes will provide important information about non-covalent interactions. These forces are crucial in determining the structure and function of biological systems. The libraries of fine-tuned self-assembled receptors will model antibody recognition properties. Furthermore, this class of receptors could be used as enzyme mimics for the catalysis of specific chemical transformations. Training content (objective, benefit and expected impact) With this training I expect to gain a broad expertise in supramolecular chemistry, in particular molecular recognition, hydrogen bond interactions and calixarene chemistry. This should complement my knowledge in covalent chemistry and metal coordination, as applie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Research on Macroeconomic Fluctuations and Trade'.

assistant: **Objectives**

The proposal is divided into three strands whose main goals are to i) study macroeconomic fluctuations, ii) identify the mechanisms that drive and propagate these fluctuations, and iii) use the empirical findings to inform and formulate models that can be used for quantitative policy and positive analysis.The first strand will exploit a new dataset to study housing markets during the build-up and aftermath of the crisis. We will document a robust pattern of history dependence in housing markets and investigate four main channels to potentially explain this pattern: Down payment requirements; matching quality; learning; and anchoring. Using these results we will build and structurally estimate a model with the aim to use in policy and positive analysis.The second strand studies an unexplored mechanism for the transmission of monetary policy. A main winner from monetary policy expansions in most countries is the government, which sees a reduction in the value of its debt and typically, better borrowing terms. We will investigate how public spending, revenues, and debt management react to changes in monetary policy; the extent to which the response of activity is driven by the public sector; the interactions between public and private sector responses; and the (intra- and inter-generational) distributional effects from monetary policy interventions. We will then formulate a DSGE model embedding a careful description of the government’s role in the transmission mechanism.The third strand studies the effect of terms-of-trade fluctuations on agricultural production and trade. We will focus on the distribution of gains from trade in markets characterized by oligopsonies buying from small farmers and exporting in international markets. We will study how this configuration, char
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'City Air Remote Emission Sensing' (CARES) under Horizon 2020.

assistant: **Objectives**

The aim of CARES is to further develop remote emission sensing instruments, data handling and analysis such that it becomes a widespread means for the monitoring and enforcement of real-world vehicle emissions, leading to reduced emissions and improvements in air quality. To reach this goal, CARES will complement existing commercial remote emission sensing instruments with two other non-intrusive and contactless methods of measuring real-world vehicle emissions to greatly expand current measurement capabilities. We develop plume chasing instruments into easy to use tools for enforcement agents to detect high-emitters in free flowing traffic. We turn fast-response air quality sensors into roadside point samplers, adding particle mass, number and size to the remote emission sensing measurement capabilities. Furthermore, we speed up the data handling of all types of remote emission sensing instruments – existing commercial types as well as those further developed within CARES – to move them towards a real-time analysis of vehicle emission data; we merge the emissions data with vehicle technical data from national vehicle registers and relevant data from traffic and air quality management systems. Third, we eliminate today’s often very time consuming data analysis by providing a suite of open-source analytical functions for a first, quick analysis of remote emission sensing data. All our innovations aim to improve the user friendliness, to bring down costs by quicker and more automated operations, and to achieve a broader deployment potential of remote emission sensing. CARES will demonstrate these developments in three major, heavily air polluted cities in Europe identifying the best fit for the respective purpose. Finally, CARES will bring together researchers, remote emi