RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fundamental and applied condensed matter research with neutrons at forschungszentrum juelich (fzj) for european users' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Description:Forschungszentrum Jülich is operating a 20 MW heavy water moderated reactor. The neutron flux in the moderator is 10^14 n/cm^2/s. Among the currently operated 16 instruments five are located in the reactor hall and use thermal neutrons: diffractometers (powder and 4-circle), triple-axis spectrometers and a time-of-flight spectrometer. A cold source using liquid hydrogen is placed close to the maximum flux and supplies the instruments in the neutron guide hall via three neutronguides. The instruments using cold neutrons comprise small-angle scattering (SANS) instruments, reflectometer, time-of-flight spectrometer (with polarisation), backscattering spectrometer, neutronspin echo spectrometer, and several special purpose instruments. One of the small-angle instruments is based on mirror optics which enables a ten times higher resolution than ordinary SANS. The neutron spin echospectrometer is using a sophisticated field correction allowing a large solid angle on a two-dimensional position sensitive detector. It is therefore especially suited for low scattering intensity experiments(e.g. incoherent scattering). All instruments of the facility are accessible within this project. The total beam time offered under this programme is 45 instrument-weeks per year.Application:The application procedure is designed to reduce the time between proposal and execution of an experiment. There are three deadlines per year and a fast access path for exceptionally promising applications. The complete refereeing procedure is done by electronic communication. All information about the facility and access conditions is available on the internet web site: proposal forms, deadlines, instrument characteristics etc. In addition calls for proposals will be published in Neutron News and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms of vascular maturation and quiescence during development, homeostasis and aging' to be submitted under Horizon 2020.

assistant: **Abstract**

Angiogenesis research has focused on the sprouting of new capillaries. The mechanisms of vessel maturation are much less well understood. Yet, the maintenance of a mature, quiescent, and organotypically-differentiated layer of endothelial cells (ECs) lining the inside of all blood vessels is vital for human health. The goal of ANGIOMATURE is to identify, validate, and implement novel mechanisms of vascular maturation and organotypic EC differentiation that are active during development, maintenance of vascular stability in adults, and undergo changes in aging. We recently identified previously unrecognized gene expression signatures of vascular maturation in a genome-wide screen of ECs isolated from newborn and adult mice. Epigenetic mechanisms were identified that control the EC transcriptome through gain and loss of DNA methylation as well as EC differentiation and signaling specification. These findings pave the way for groundbreaking novel opportunities to study vascular maturation. By characterizing functionally diverse types of blood vessels, including continuous ECs in lung and brain and sinusoidal ECs in liver and bone marrow, the ANGIOMATURE project will (1) determine up to single cell resolution the transcriptional and epigenetic program(s) of vascular maturation and organotypic differentiation during adolescence, (2) analyze the functional consequences of such program(s) in differentiated ECs and their adaptation to challenge, and (3) study changes of maturation and differentiation program(s) and vascular responses during aging. We will towards this end employ an interdisciplinary matrix of approaches involving omics, systems biology, conditional gene targeting, organoid cell culture, and experimental pathology to create a high-resolution structural and funct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tunable light tightly bound to a single sheet of carbon atoms:graphene as a novel platform for nano-optoelectronics' (CARBONLIGHT).

assistant: **Innovation**

Graphene, a one-atom-thick layer of carbon, has attracted enormous attention in diverse areas of applied and fundamental physics. Due to its unique crystal structure, charge carriers have an effective mass of zero and a very high mobility, even at room temperature. While graphene-based devices have an enormous potential for high-speed electronics, graphene has recently been recognized as a photonic material for novel optoelectronic applications.Interestingly, graphene is also a promising host material for light that is confined to nanoscale dimensions, more than 100 times below the diffraction limit. Due to its ultra-small thickness and extremely high purity, graphene can support strongly confined propagating light fields coupled to the charge carriers in the material: surface plasmons.  The properties of these plasmons are controllable by electrostatic gates, holding promise for in-situ tunability of light-matter interactions at a length scale far below the wavelength.This project will experimentally investigate the new and virtually unexplored field of graphene surface plasmonics, and combine this with other appealing properties of graphene to demonstrate the unique potential of carbon-based nano-optoelectronics. The aim is to explore the limits of unprecedented light concentration, manipulation and detection at the nanoscale, to dramatically intensify nonlinear interactions between photons towards the quantum regime, and to reveal the subtle effects of cavity quantum electrodynamics on graphene-emitter systems. This research will reveal the far-reaching potential of a single sheet of carbon atoms as a host for light and electrons at the nanoscale, with prospects for novel nanoscale optical circuits and detectors, nano-optomechanical systems and tunable artificial qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of intensified water treatment concepts by integrating nano- and membrane technologies' (NAMETECH) under Seventh Framework.

assistant: **Objectives**

The Nametech project harnesses benefits of nanotechnology to bring about improvements in membrane filtration for advanced water treatment. The general objective is to strengthen the European membrane market by making nanotechnology available to large scale European membrane manufacturers. A unique feature of the project is the knowledge transfer between the experienced membrane manufacturer Norit and the coating expert and new-comer to the membrane field Agfa Gevaert. The S&T focus is on the use of nano-structured materials to alter the physical and chemical properties of polymeric ultrafiltration membranes and thereby improving the filtration performance at macroscale installations. The project aims at adapting commercial nanoparticles such as TiO2 and Ag for the modification of UF membranes to reduce fouling, and thus improve its permeability (i.e. Technology Path 1). In Technology Path 2 and 3, the potential of using active nanoparticles, such as bionano-catalysts, in combination with membranes is examined to remove micropollutants such as chlorinated compounds, nitroaromatic compounds or redox active metals, thus improving the water quality. A specific novelty is the development of an integrated permeate channel concept, whereby the nanoparticles are embedded in 3D textiles, functioning as membrane support and permeate channel. The nanoparticles will be deposited on the membrane surface or embedded in the membrane (mixed matrix). The S&T challenges regarding the modification of the nanoparticles, the deposition of the nanoparticles on membrane surface as well as the production of nano-activated membranes (NAMs) will be addressed in WP 1, 2 and 3. The newly developed NAMs will be tested at laboratory scale (WP 4) before selecting the most promising concept for testin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biotechnology Ethics: deepening by research, broadening to future applications and new EU members, permeating education to young scientists.' (BIOTETHED), addressing dissemination and exploitation.

assistant: **Impact**

Biotechnology Ethics is becoming a better-defined discipline in the realm of Bioethics, addressing ethical issues emerging from the application of sciences to biological advances and industrial technology. Ethics must keep abreast of the rapid scientific a nd technical developments, and this requires continuous research in philosophy and continuous dialogue with ice-breaking scientists. At the same time, the latter realize that only interdisciplinary studies can provide them with the judgement and decision-m aking capacity necessary for their societal role; therefore their need of BT-Ethics education grows exponentially. Tying research to teaching has been the goal of a strategic action spanning 2003-2005 and producing BT-Ethics courses aimed at PhD students i n Europe. Ten of the groups that have driven this progressively successful initiative propose now to expand their activity in several dimensions: a) towards emerging issues from new fields of biotechnological application ? e.g. in nano-neuro-and immunotech nologies, stem cell studies, GM food, human reproductive technologies, b) towards the extension towards new EU member states, c) toward the consolidation and continuity of the educational effort. For b) we rely on the membership of active research groups f rom Hungary, the Czech Republic and Lithuania; for a) and c) we can count on the partnership of EMBO, whose Science and Society Programme promotes balance discussions on molecular biology via a range of stimulating activities that support public communicat ion from scientists, and target natural disseminators such as teachers. The tools of this action are interdisciplinary encounters with scientists, annual courses located in the Eastern regions of Europe, electronic databases and publications; all activitie s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bispecific monoclonal antibody technology concept' (BMC).

assistant: **Concept**

Monoclonal antibodies (mAbs) represent a new form of protein-based drug having demonstrated a significant impact on the treatment of several types of cancers.Their specificity towards cell surface receptors makes them able to target and destroy tumour cells. However, a lot of progress is still necessary to understand the mechanism of binding and activity of antibodies in order to improve their targeting capabilities and their efficiency.To reach these objectives, the BMC project proposes to:- Develop a recombinant bispecific mAb with tetrameric binding sites, directed against two different antigens expressed on the same target tumour cell;- Develop new bispecific or bifunctional molecules with the property of crosslinking two different receptors on the surface of the cell;- Modify the carbohydrate moiety of bispecific antibodies and the tumour targeting of the complement regulator molecule, properdin, to trigger the activation of the complement enzymatic cascade at the tumour site.The recombinant molecules are directed against a selected target antigen for mAb therapy, CDS, as well as a B-cell marker to be selected, in order to treat a specific type of leukaemia, the B-CLL. However, the described innovative cancer immunotherapy strategy will also be extended to the treatment of many other types of cancers especially all carcinomas.The partnership gathers 9 partners recovering the needs of the BMC project:- 7 RTDs specialized in genetic engineering (CNRS), innovative molecules design (UNIL), antibodies vectorisation with nanoparticles (HUJI), CDC activity improvement and cell lines and animal models development (GIENSAT), mechanisms of therapeutic antibodies on patients' cells (OORRBG), toxicology studies and standardization (ITEM);- 2 biotechnology SMEs specialized in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EU-BSEC Energy and Climate Policy Network' to be submitted under Sixth Framework.

assistant: **Abstract**

Energy and Climate Policy are prominent areas for cooperation among BSEC member states, especially in the context of the security of the EU energy supply as well as emerging regional energy and emission markets. The Black Sea region is moving towards a new phase of development intending also to assimilate and participate in the ERA procedures. Moreover, in the most official manner (BSEC Energy Ministers in the Baku Declaration) the states of the region declared their preposition to support initiatives resulting in the convergence of national energy and climate policies.The aim of PROMITHEAS-2 is to establish a network of research entities focusing on national and EU priorities in the aforementioned thematic areas and mobilizing the regional scientific potential. The project will:- Define the most promising fields of collaboration in Energy and Climate Policy research among the countries of the region and with the EU;- Identify suitable regional stakeholders and scientific potential for the establishment of a training and informative mechanism aimed at the widest possible diffusion of knowledge;- Support the dialogue and strengthen the cooperation between Commission, EU Member and Associated Candidate States, and Third Partner Countries specifically in the fields of Energy and Climate Policy within the framework of ERA and FP6 (FP7) procedures.These objectives will be achieved through a range of planned activities: website, one seminar (12 participants from the BSEC countries), three workshops (minimum 3x60 participants from three countries), one conference (minimum of 100 participants), four awards, one semi-annual bilingual (English - Russian) publication and three ad hoc visits. Particular attention will be paid to the identification of suitable institutions for the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'New approaches to the study of economic fluctuations'.

assistant: **Objectives**

Each partner in the project has the expertise necessary to provide training. This network aims to develop new approaches to quantitative analysis of economic fluctuations. A number, of new approaches to the analysis of programmes for the Young Researchers. This will take the form of active fluctuations have emerged recently in the theoretical literature, which participation in seminars and workshops (all partners have at least one active seminar series at their institution) and participation in summer highlight the roles played by the heterogeity of firms and households, rigidities in price and wage adjustment, and externalities and multiple schools. In addition, partner institutions are able to attract top-class equilibria. There is, however, little empirical evidence on the importance-visiting scholars, who often teach specialized courses on selected topics of these factors in explaining fluctuations at the levels of the nation.The network will employ a variety of procedures in order to ensure that a wide range of high-quality candidates are identified to fill the region, the household and the firm. The network will develop new positions funded by the network statistical methods suitable for extracting both dynamic and cross-sectional information and apply these techniques to newly available datasets. The project brings together eight leading institutions from seven EU countries to undertake three connected lines of research: to study the aggregate characteristics of the European business cycle with the goal of establishing the 'main facts' (dating of turning points, co movements between aggregates in different countries, possible asymmetries of expansions and recessions); to use disaggregated data - at the regional, sectoral and firm level - to investigate the link b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Radiochemistry on chip'.

assistant: **Innovation**

The aim of this project is the design, fabrication and implementation of a microdevice able to synthesise radiopharmaceuticals for Positron Emission Tomography (PET) analysis, a technique usually employed in medicine for its unsurpassed sensitivity and specificity. We propose to develop a modular microfluidic architecture which can be used for standard synthesis protocols as well as for R&D of new radiopharmaceuticals. In order to achieve this target, emerging technologies in the field of micro reactors and micro total analysis systems (μ–TAS) have to be applied to the synthetic pathways typical for radiopharmaceuticals, thus improving the traditional approach in terms of efficiency and safety. A deep knowledge of the chemical processes and of the separation techniques involved in radiosynthesis is needed to define the features of the modules to be fabricated as well as state of art techniques in the field of micro fabrications and microfluidics for the implementation of high performance micro devices. Standard synthesis protocols and new radiopharmaceuticals will be carried into the micro devices thus evaluating their efficiency and versatility. The yields and the purity of the products produced into micro devices will be compared with those obtained with traditional methods and tested in vivo for Positron Emission Tomography (PET) analysis. To ensure the success of the overall project, we will take advantage of a strict collaboration between chemists, physics and engineers in an interdisciplinary approach. For this purpose, we built an international network collaboration between academic partners dealing with the technological side, an industrial partner for checking the system robustness and a physiological clinical institute able to evaluate the end-user outcome.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Broadband technologies transforming business models and challenging regulatory frameworks - lessons from the music industry'.

assistant: **Innovation**

In the late 1990s, MP3 became one of the most important Internet search objects, indicating that music played a dominant role in network content. In 2003, the file-swapping program Kazaa topped the Internet search list. Over 340 million copies of Kazaa's Fast Track software had been downloaded by December 2003. File-sharing or Peer-to-Peer activities (P2P), mainly involving audio/audio-visual products, have become the main driver of broadband traffic, accounting for over 50% of capacity. P2P technology has allowed millions to engage in interactivity (inclusion) and provided new methods for marketing intellectual property and knowledge related products. At the same time, it has created serious problems for traditional business models and modes of digital asset protection.With content owners' strategies leading to the closing of earlier applications such as Napster, and driving file-sharing development to higher degrees of user anonymity, major problems for optimising network traffic management have emerged. As with every popular Internet application, P2P has also become a target for malicious software and lacks the security sophistication of its technological cousin, the GRID. A research task is to evaluate and compare both threats and opportunities, providing a better basis for policy-making.New business models are appearing in the Peer-to-Peer environment, particularly in the music industry, a key area where early adoption of new technology has traditionally demonstrated important lessons for many other industrial sectors. MUSICLESSONS will combine technological and socio-economic research into these conflicting trends with pan-European studies of consumer behaviour. It will deliver examples of emerging business models, analyses of technological constraints and insight