RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International Symposium for Magnetic Resonance in Cardiovascular Research' (1998-2002).

assistant: **Innovation**

The objectives of this meeting are to bring together clinicians and basic research scientists who have an interest in magnetic resonance imaging (MRI) and spectroscopy (MRS) of the heart and vascular system. Topics covered will range from clinical/diagnostic applications of MRI and MRS to their use as basic research tools. This is the first time that a meeting on this subject will be held in the United Kingdom. The meeting will provide an invaluable vehicle to show the latest developments in the application of magnetic resonance in clinical and basic heart research. The meeting is one of a series of international meetings entitled 'Magnetic Resonance in Cardiovascular Research'. The first was in 1994 in Düsseldorf, organised by Jürgen Schrader from the lnstitut für Herz- und Kreislaufphysiologie. At that time it became clear that there was the need for a regular event, bringing together the basic and clinical scientists working in this field. The second meeting was held in Würzburg in May 1996, the third meeting took place in Utrecht in September 1997, the fourth meeting was in Würzburg 1998 and the most recent meeting took place on September 8th & 9th in Marseille 2000.The invited speakers will be eminent scientists from all areas of cardiovascular MR research, from cardiologists to physicists. We propose to invite ~18 speakers from Europe, including Professors Axel Haase, Renee Ventura-Clapier and Jurgen Schrader, ~8 speakers from the United States, including Professors Paul Bottomley, Joanne Ingwall and Gerry Pohost and ~10 speakers from the United Kingdom, such as Professors Sir George Radda, Hugh Watkins and Peter Morris. We plan to have 6 sessions, each starting with a lecture and two ending with a debate.L%Topics covered will be:- MRS studies of cardiac metabolis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Streamlining the optimisation of Sustainable Thermal Energy systems and Prototype technologies in process industries'.

assistant: **Objectives**

European process industries face significant challenges in a changing geopolitical landscape, under the threat of climate change and against fierce international competition. In this context, boosting the resilience and competitiveness of process industries, while taking surefooted steps towards climate neutrality is of existential importance. StreamSTEP is the vision of 31 organisations across EU, Switzerland, Norway and UK, aspiring to trigger significant improvements of how heating energy is managed within industrial processes. The project will address processes that generate waste heat across all temperature grades, from 135oC to over 1400oC, deploying five innovative heat exchanger prototypes for challenging applications and achieving flexible operation across multiple heat sinks. Heat upgrade will be managed through high temperature heat pumps, achieving outlet temperatures at 150oC and at 215oC, with improved performance through ejector technology and the capacity to operate dynamically across a range of required temperatures. Enablers of these innovations are advanced manufacturing techniques, achieving superior material performance through novel material alloys. The system will be demonstrated across five sectors: non-ferrous metals, ceramics, minerals, plastics and refining. The demonstrators will be supported by impact boosting resources, de-risking the investment and accelerating commercialisation.A holistic process digital twinning pipeline will be integral to these advancements, as it will provide the infrastructure to deploy powerful optimisation agents, addressing energy balance, intermediary storage, GHG avoidance and data-driven LCA.The effects of the StreamSTEP project will be significant, as the recovery and efficient reutilisation of the majority of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Forging the blades of the future with composite materials with circular, safe and sustainable design' (BLADE2CIRC).

assistant: **Innovation**

BLADESCIRC will be one of the pioneering projects of exploring bio-based approaches to improve the sustainability of the wind energy sector.  To this end, the project will research on biobased materials to develop new composite. These new composites will combine high strength biobased carbon fibres and biobased structural resins with a dynamic performance. The dynamic performance provided to the structural resins at molecular and supramolecular level will be the bases to design and develop a set of technologies for improving the lifetime, efficient decommissioning and increase the circularity of the offshore and onshore wind energy systems: i) Coatings with self-healing and ompniphobic properties for lifetime spanning, ii) Debondable adhesives formulation for enhanced recycling and maintenance, and iii) Green solvents and evolved enzymes for chemical and enzymatic degradation processes to recover high-quality fibres. The proposed innovations are grounded on the results of previous or on-going projects (ECOXY, BIZENTE, VIBES, LIBRE or BIO-UPTAKE) that have shown the high potential of the biobased solutions, which, in addition to the modelling, testing, validation and multi-criteria assessment stages, will ensure that the new composite will have a competitive performance compared to the existing and commercial solutions.BLADESCIRC will collaborate with the ETIP Wind to engage stakeholders and promote collaborations and disseminate the results in the most relevant scientific forums.


**Keywords:** wind turbine blades, wind energy, composites, biobased, biocomposites, circularity, recyclability, lignin carbon fibres, thermoset materials, ezymatic degradation, debonding, self-healing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Therapeutic Avenues for dynein-related Ciliopathies' (TREATCilia).

assistant: **Innovation**

Background: Cilia are hair-like, microtubule-based organelles protruding from most quiescent mammalian cells. They play essential roles in cell signalling (primary cilia) as well as movement of fluid (motile cilia). Although individually rare, cilia dysfunction affects up to 1 in 500 people in Europe, significantly reducing quality of life and lifespan due to dysfunction of multiple organs, including the kidneys, liver, heart, brain, retina, airways and the skeleton. To date, treatment is purely symptomatic.Aim and Approach: TREATCilia aims to decipher novel treatment avenues and improve clinical management for dynein-related ciliopathies. Next-generation sequencing based gene identification for dynein-related ciliopathies (ciliary chondrodysplasias and Primary Ciliary Dyskinesia, PCD) is employed to dissect the molecular basis and identify new therapeutic targets. Revealing genotype-phenotype mechanisms and their underlying cell signalling defects provides further insight into potential treatment options. Novel innovative curative approaches include high-throughput substance screening in model organisms such as the green algae Chlamydomonas and mammalian cells specially adapted for this purpose. Impact: Identification of novel ciliopathy genes will not only improve the biological understanding, but also reveal new treatment candidates. Furthermore, scrutinizing the molecular mechanisms of disease yields pharmacological entry points. TREATCilia develops a pre-clinical pipeline towards gene and mutation-specific treatments for hereditary conditions resulting from dynein-related ciliary dysfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and application of Novel, Integrated Tools for monitoring and managing Catchments' (INTCATCH) targeting Horizon 2020.

assistant: **Abstract**

INTCATCH will instigate a paradigm shift in the monitoring and management of surface water quality that is fit for global waters in the period 2020-2050. INTCATCH will do this by developing efficient, user-friendly water monitoring strategies and systems based on innovative technologies that will  provide real time data for important parameters, moving towards SMART Rivers. The business model will transform water governance by facilitating sustainable water quality management by community groups and NGOs using a clouds data linked to a decision support system and eco-innovative technologies.The INTCATCH project will use demonstration activities to showcase eco-innovative autonomous and radio controlled boats, sensors, DNA test kits and run-off treatment technologies. Actions which develop and evaluate these in a range of catchments will address the important innovation barriers to uptake, notably, a lack of knowledge of new technologies and their capabilities, identified by the European Innovation Plan (EIP) on water. By conceptually moving the laboratory to the ‘field’, the monitoring techniques that will be developed aim to supersede the inefficient, time dependent, costly and labour-intensive routine sampling and analysis procedures currently deployed to understand the quality of receiving waters. It will compliment routine monitoring that is required for baseline datasets, but also enable cost-effective impact and management investigations. INTCATCH will incentivise stakeholder innovation in monitoring and will facilitate new financing for innovation through its innovative franchise business model and empowerment of community groups and NGOs. The market ambition is that the INTCATCH business will facilitate an eco-innovative approach to deliver good quality water bo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Composite Pipes and Fittings for Aero-Engines Dressing' (COMPIPE) targeting Seventh Framework.

assistant: **Abstract**

The object of this project is to update the concept of aero-engine dressing to the most advanced concepts already used in commercial aircrafts.The existing design concepts and components utilised within the engine dressings have remained largely static for a long period of time; there is little difference in the components and materials used in the engine dressings on the latest Trent engines to the early RB211’s.In today’s competitive aero-engine market, the primary product discriminators are cost-driven. Typical cost savings of 20-30% delivered by PMCs in replacing incumbent metal parts; therefore, provide added incentive for wider application of these materials. With these impressive advantages on offer, it may seem difficult to understand why composite materials do not dominate the latest civil and military engines.COMPipe will allow to design and manufacture an agreed set of non-metallic pipes and support systems to replace traditional metallic variants in engine dressings. It will also identify the manufacturing processes that could be used to scale up the production requirements to meet future delivery needs.The scientific and technical objectives to reach along the project will bei.To design and develop a new concept of non-metallic pipes and fittings suited for aero-engines, specifically drains, scavenge, sensor and vent linesii.To select materials meeting the required environmental constrains, both in the range of temperatures and in the chemical resistance to different products present in the aero-engine, such as Skydrol hydraulic fluid, oil and aviation fuel.iii.To develop one or more manufacturing practices and to improve existing methodologies driving toa.To a product standard with a near to zero wall´s porosityb.To produce 3D geometries of according to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Active creation, delivery and management of efficient context aware services', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

CONTEXT aims to design, develop and assess innovative models and solutions for an efficient provisioning of context-based services making use of active network technology on top of fixed and mobile networks. This will allow the composability and dynamic adaptability of current and future services for the benefit of the global users. From the technical point of view the CONTEXT solution will span into three domains, namely: the service layer domain, the Active Networks (AN) domain and the IP domain. In the service layer domain, we will deal with modelling of the information that expresses the context of services and establishing a framework for the creation of context aware services. The AN based solution, with appropriate APIs to control the IP domain, will allow the actual delivery of context based services and the adaptation of the policy based management concept in order to their management. CONTEXT aims to design, develop and assess innovative models and solutions for an efficient provisioning of context-based services making use of active network technology on top of fixed and mobile networks. This will allow the composability and dynamic adaptability of current and future services for the benefit of the global users. From the technical point of view the CONTEXT solution will span into three domains, namely: the service layer domain, the Active Networks (AN) domain and the IP domain. In the service layer domain, we will deal with modelling of the information that expresses the context of services and establishing a framework for the creation of context aware services. The AN based solution, with appropriate APIs to control the IP domain, will allow the actual delivery of context based services and the adaptation of the policy based management concept in order to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Advancing ultrasound-assisted biopolymeric nanofillers from seaweed biomass as sustainable resources for the development of nanofood systems' (SonoNano) targeting Horizon Europe.

assistant: **Abstract**

The global food industry is shifting towards sustainability due to environmental concerns, resource depletion, and increasing demand for functional foods, driven by a projected population increase to nearly 10 billion by 2050. In this context, seaweed biomass is an abundant source of seaweed-derived bioactives (SDBs) such as proteins (SDP), starches (SDS), and polyphenols (SDPPs), which are appealing renewable bioresources for sustainable food systems. Initially, we aim to establish high-throughput screening of seaweed bioactives (SDP, SDS, and SDPPs) and estimate their therapeutic potential (WP1). However, there is still a lack of understanding regarding the nature and chemistry of SDP, SDS, and SDPPs, which hinders their incorporation into food matrices. The objective is to determine which combination of SDP, SDS, and SDPPs is important for nanofood systems and to understand their implications on the development and processing practices in the food industry. Secondly, we aim to be the first to establish a clear link between the structures of encapsulating raw materials (SDP and SDS) and the functionality of their complexes (WP2). Then, the delivery properties of ultrasound-assisted SDP-SDS complex nanoparticles will be investigated with SDPPs as a core material, and the effect of the formation mechanisms of biopolymeric nanofillers on their functionalities will be analysed (WP3). Finally, the therapeutic potential of SDBs-stabilised biopolymeric nanofillers for sustainable nanofood production with improved functionalities, bioaccessibility, and nutritional properties will be explored (WP4). The proposed project will eventually provide a novel pathway for European food product manufacturers to develop nutrient-packed nanofood products. Overall, efforts are being made t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regulation of bone metastases by age-associated angiocrine signals' under Horizon 2020.

assistant: **Concept**

Blood vessels form a versatile transport network and provide inductive signals called angiocrine factors to regulate tissue-specific functions. Blood vessels in bone are heterogeneous with distinct capillary subtypes that exhibit remarkable alterations with age. Bone is the most prevalent site of metastasis, and ageing is linked to the reactivation of dormant tumor cells (dorTCs) and metastatic relapse. Bone remodeling processes are also associated with metastatic relapse. Here, I will define the role of distinct vascular niches in regulating the fate of DTCs in bone. Finally, I will unravel the age-related angiocrine factors and identify key angiocrine signals that drive the reactivation of dorTCs. I will employ a powerful combination of advanced 3D, intravital, and whole body imaging, cell specific-inducible mouse genetics, transcriptional profiling and bioinformatics in an unprecedented manner to achieve my goals. New cutting-edge techniques such as advanced 3D and 4D bone imaging are important aspects of my proposal. I will also define the role of highly promising novel candidate age-related angiocrine signals with sophisticated inducible endothelial-specific humanised mouse models. My work will break new ground by unraveling a repertoire of age-related angiocrine factors and will contribute to a wider scientific community in bone, blood, and age-related diseases. This interdisciplinary work at the frontiers of bone, cancer and vascular biology will provide the first conceptual link between vascular ageing and bone metastasis and will contribute towards the development of therapeutic strategies for targeting DTCs in bone.


**Keywords:** Bone angiogenesis, angiocrine factors, bone marrow microenvironment, metastatic relapse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'GENETIC IMPROVEMENT OF FUNCTIONAL TRAITS IN CATTLE' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Modern cattle production systems are caracterized by high levels of product output (milk and beef) per animal. The direct, obvious relationship between product output per animal and farm profitability is an incentive for ongoing technological development towards increased production levels. However, single-minded increase of production per animal will lead to a deterioration of animal health and reproductive performance and, therefore, increased metabolic stress and reduced longevity. There is a growing consumer concern regarding the suffering of animals from diseases and disorders, and regarding the use of antibiotics for treatment and their effects on both animals, products and humans. Therefore, technological development should be aimed at a balanced improvement of production traits and functional traits: characteristics of an animal which increase efficiency of production not by higher output of products but by reduced costs of input, such as genetic disease resistance, reproductive capacity, and feed intake capacity.Directional animal breeding can contribute to avoiding deterioration and possibly improving functional traits in cattle production.The recognition of the importance of functional traits, and the possible role of animal breeding, has led to research activities in many countries. Research focusses on tool development - unambigious trait definition, reliable trait recordig, and proper evaluation procedures - and tool implementation optimization of breeding programmes including production and functional traits. This research requires a multi-disciplinary effort; relative to production traits, functional traits are difficult to measure on a large number of animals, are more directly representing complicated biological-physiological mechanisms, and have other