RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cortactin signalling and actin dynamics control in cell migration and bacterial invasion' (CORTACTINNMQ).

assistant: **Concept**

Actin-based motility underlies multiple cellular processes. Polymerisation of actin from the monomeric to the filamentous form is mediated by the Arp2/3 complex. This complex has to be activated to be functional. To date there are two families of proteins that directly bind and activate the Arp2/3 complex through a conserved DDW motif: Wiskott-Aldrich syndrome proteins and cortactin. Initially there was not functional relationship between them until we demonstrated that cortactin binds and activates N-WASP via its SH3 domain. Thus cortactin can activate actin synthesis directly through its N-terminal DDW motif, or indirectly by binding to N-WASP via its c-terminal SH3 domain. Furthermore we demonstrated that cortactin activation of N-WASP is positive/negatively regulated by erk/src phosphorylation of cortactin respectively, probably by regulating the accessibility of its SH3 domain.Based on these in vitro experiments, we proposed a switch on/off mechanism, which could be an important control mechanism of acti n remodelling. Thus cortactin has emerged as a multidomain protein that acts as a scaffold that redistributes signals to promote Arp2/3 complex mediated actin synthesis in a variety of cellular processes. The major objective of the project is the validation of the model in vivo.The questions we will try to address are:1) Cortactin is considered an oncogene. How is the activation state of cortactin contributing to its oncogenic potential?2) Cortactin redistributes from the cytoplasm to the cortical cytoskeleton. How is the switch affecting its localization? Are there differences in the final actin structure formed? Is it regulating cortactin binding pattern?3) Cortactin is implicated in pedestal formation by EPEC. Is the switch implicated in pedestal formation or in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The role of micro-aeration-based processes for the valorisation of polluted sludge to value-added chemicals'.

assistant: **Innovation**

Industrial and municipal biological wastewater treatment plants (WWTP) generate vast amounts of sludge (SS) as a by-product. The total annual production of sludge currently surpasses 13 million tonnes of dry solids (DS) in the EU, even excluding sludge production from industrial on-site WWTP. Sewage sludge (SS) mainly contains non-toxic organic matter that can be converted to value-added compounds such as carboxylic acids, alcohols, and energy carriers. Furthermore, macronutrients such as nitrogen and phosphorus and micronutrients (e.g., potassium and iron) that are essential for crop growth are present as well, making sludge an interesting organic fertiliser. However, mainly depending on the composition of the wastewater and the pollutant’s biodegradability, SS typically contains various potential hazardous contaminants (OMP) such as adsorbable halogenated organic compounds (e.g., PFAS, AOX), phenols, sulfates, aromatics, active pharmaceutical ingredients (APIs) (e.g., antibiotics, endocrine disruptors), pathogens (viruses, bacteria, etc.), microplastics and heavy metals (HM). It is clear that there is an urgent need for technological strategies that tackle both the increasing presence of contaminants in sludge and allow efficient resource recovery from sludge. However, current alternative sludge management strategies fall short to properly respond to the growing demands of a sustainable society and unfortunately, a significant amount of sludge is incinerated or (even worse) landfilled.OXYCON will therefore explore the use of micro-aeration as an innovative technique to simultaneously (i) degrade selected OMP, (ii) remove HMs, and (iii) enhance carboxylic acid production as biobased chemical building block during (subsequent) anaerobic fermentation of the treated sludg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Oral antibiotic outpatient therapy vs. placebo in the treatment of uncomplicated acute appendicitis: a randomized double-blind placebo-controlled noninferiority trial' under Horizon Europe.

assistant: **Concept**

Acute appendicitis is one of the most common surgical emergencies worldwide. For over a century, surgical removal of the appendix has been considered the only treatment option. Landmark trials by our experienced APPAC team have shown that imaging confirmed uncomplicated acute appendicitis is not a surgical emergency defining antibiotics to safe and effective also with only oral antibiotics avoiding unnecessary surgeries resulting in major cost and resource savings. However, the role of antibiotics remains a major knowledge gap. Our pilot APPAC III showed that even symptomatic treatment (placebo) may be sufficient warranting a larger noninferiority trial to assess whether antibiotics are needed in the treatment of uncomplicated acute appendicitis.APPAC IV is a randomized double-blind multicenter clinical trial comparing oral moxifloxacin with placebo in an outpatient setting. APPAC IV aims to evaluate whether antibiotics and hospitalization or both can be omitted in the treatment of uncomplicated appendicitis further significantly increasing cost savings and patient satisfaction; almost 2/3 of all appendectomies (approx. 550.000 operations in Europe), the associated hospital stays, and potentially also antibiotics could be avoided.The growing global health issue of antibiotic resistance threatens effective prevention and treatment of infections. Studies on rational use of antibiotics are warranted and especially in the changing treatment paradigm of such a common disease. The translational MAPPAC II (Microbiology APPAC) substudy includes serum, rectal and fecal samples of the APPAC IV trial patients pre- and post-therapy. The effects of antibiotics on gut microbiota, gut health and correlation to serum cytokines are evaluated in this unique real-life randomized patient c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rotorcraf Drag Reduction' (ROD), addressing dissemination and exploitation.

assistant: **Impact**

The project pertains to the wind tunnel testing of a common helicopter platform of the heavy-weight class. The aim of the testing activity is the evaluation of the effectiveness (mainly in terms of drag reduction) of the shape optimisation performed by GRC consortium on severall components. Both original and optimised models will be tested to assess the optimisation effectiveness by comparison.The tests will complemented by a CFD simulation activity and finally a physical interpretation of the obtained results will be presented.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Efficient Computational Methods for Active Flow Control Using Adjoint Sensitivities' (KAFKA).

assistant: **Innovation**

Active Flow Control (AFC) mechanisms have tremendous potential in improving flow characteristics in a wide variety of sectors. For effective AFC design, it is essential to determine the sensitivity of each of the control parameters to the flow property of interest. Adjoint methods provide the sensitivity of the objective function to any number of input parameters at a reasonable additional cost. They are based on simple RANS turbulence modelling, which captures poorly the physics of flow especially in the presence of complex flow features such as flow separation, which can be effectively eliminated by flow control. Recently developed Reynolds Stress Models (RSM) display significant improvement in the flow prediction capacity as compared to conventional RANS models, yet adjoints with RSM are not yet available. An alternative for accurate flow prediction is Large Eddy Simulation (LES). Unfortunately resolving the chaotic turbulent motion results in exponential growth of the gradients.Our first objective is to develop an effective discrete adjoint method with an accurate and stable RSM, and compute sensitivities in complex flows involving  active control mechanism applied to realistic wing geometries. Although RSM outperforms conventional turbulence models in a host of applications, there is a need for further physics-based calibration for specific flows. Our second objective is to use the adjoint method to drive the model coefficients to their optimum value such that the model results match with high-fidelity simulation data yielding a better turbulence model, which can be applied for effective flow control design in bluff body with severe rear flow separation. Our third objective will be to develop adjoint approaches for chaotic LES flows using the hosting groups' innova
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Complexity and evolution of photonic nanostructures in bio-organisms: templates for material sciences'.

assistant: **Innovation**

The physical explanation of the extraordinary appearances of many living entities faces complexity. Using a combination of microscopy techniques, we wish to develop knowledge of the micro- and nano-morphology of specific bio-organisms, selected for their particular ability to use light scattering as part of their living mechanisms.This knowledge will be complemented by the precise characterization of the light filtering functions of the structurated organs, making use of micrometer-resolved spectrophotome tric and thermal exchange measurements. The relation between these and the optical density will be consolidated by large-scale numerical simulations.On the other hand, the targeted organisms will be studied from the point of view of ecological and phenological history. In particular, closely related, or competing species will be designated for further physical examinations. Interdisciplinary exchanges, including, when available, paleontological data, will attempt to determine whether the optical scattering mechanisms constitutes a possible evolutive advantage which could explain the permanence of the bio-organism in its ecosystem.With regard to the problem of complexity, different methods will need to be developed at each stage of the investigation. The study of the bio-organism in its environment, eventually at different evolutionary epochs, will require an analysis of a large number of interactions and dependencies among living populations; the experimental and theoretical study of the light-filtering functions will also cope with complexity, as it requires to account for a multi-dimensional hierarchical data set, including the knowledge of reflection, absorption and, polarization changes as a function of frequency, incidence and emergence angles, at various points o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Estonian Key Account Management Services'.

assistant: **Concept**

The objective of the project is to enhance the innovation management capacity of Estonian SMEs. The action is aimed attwo kinds of SMEs - beneficiaries of the SME Instrument of Horizon and SMEs with significant innovation activities and ahigh potential for internationalisation. For beneficiaries of the SME Instrument, the service package (the Key AccountManagement service) consists of identifying weaknesses in the innovation capacities of the beneficiary; identifying suitablecoaches (based on the assessment in the first step) to address the identified weaknesses and moderating the coach-clientrelationship; and accompanying the beneficiary through the SME Instrument project. The service packages outside thescope of the SME Instrument (the “Enhancing the innovation management capacity of SME's” service) consist of carryingout a diagnostic audit of the selected SMEs; and developing and implementing a tailored action plan to improve the SME’scapacity to manage innovation processes.Within the current action, the ESTINNO-NET consortium aims to provide the 7-day service packages to 53 SMEs.


**Keywords:** Key account management, Enhancing the innovation management capacity of SMEs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Climate change across Cenozoic cooling steps reconstructed with clumped isotope thermometry'.

assistant: **Objectives**

The Earth's climate system contains a highly complex interplay of numerous components, such as atmospheric greenhouse gases, ice sheets, and ocean circulation. Due to nonlinearities and feedbacks, changes to the system can result in rapid transitions to radically different climate states. In light of rising greenhouse gas levels there is an urgent need to better understand climate at such tipping points. Reconstructions of profound climate changes in the past provide crucial insight into our climate system and help to predict future changes. However, all proxies we use to reconstruct past climate depend on assumptions that are in addition increasingly uncertain back in time. A new kind of temperature proxy, the carbonate ‘clumped isotope’ thermometer, has great potential to overcome these obstacles. The proxy relies on thermodynamic principles, taking advantage of the temperature-dependence of the binding strength between different isotopes of carbon and oxygen, which makes it independent of other variables. Yet, widespread application of this technique in paleoceanography is currently prevented by the required large sample amounts, which are difficult to obtain from ocean sediments. If applied to the minute carbonate shells preserved in the sediments, this proxy would allow robust reconstructions of past temperatures in the surface and deep ocean, as well as global ice volume, far back in time. Here I propose to considerably decrease sample amount requirements of clumped isotope thermometry, building on recent successful modifications of the method and ideas for further analytical improvements. This will enable my group and me to thoroughly ground-truth the proxy for application in paleoceanography and for the first time apply it to aspects of past climate change acros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced multi-functional machinery for outdoor applications' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The IBIS project aims to develop the required technology for a new generation of co-efficient, multi-functional machinery for outdoor applications. This will be achieved by developing concepts for flexible and interchangeable boom structures, innovative, energy efficient and intelligent actuator technologies, advanced automatic motion control strategies for the machine operation and technologies required for onboard diagnostic and area monitoring systems. Due to reduced fuel consumption of new hydraulic system solutions this contributes to a significant reduction of the exploitation of primary energy resources. By developing onboard condition and area monitoring in combination with sophisticated automatic motion control of the machine a highly improved operability, interchangeability and worker's safety will be achieved. The developed technologies will be implemented into three technology platforms for testing and evaluation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Winter School Quantum Simulations of Complex Many-Body Systems: From Theory to Algorithms'.

assistant: **Concept**

This Winter School will teach modern quantum simulation techniques and their implementation on high-performance computers, in particular on parallel systems. The focus is on numerical methods, which are tailored to treat large quantum systems with many coupled degrees of freedom ranging from superfluid Helium to chemical reactions. Among others, the following topics will be covered:- Diffusion and Green's function Monte Carlo- Path integral Monte Carlo and molecular dynamics;- Car-Parrinello / ab initio molecular dynamics;- Real-time quantum dynamics for large systems;- Lattice and continuum algorithms;- Exchange statistics for Bosons and Fermions / sign problem;- Parallel numerical techniques and tools;- Numerical integration and random numbers.This strongly interdisciplinary School aims at bridging three gaps" in the vast field of large-scale quantum simulations. The first gap between chemistry and physics, the second one between typical graduate courses in these fields and state-of-the-art research, and finally the one between the Monte Carlo and molecular dynamics communities.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2001-00391-1.pdf"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ManipULation of photoinduced processes bY reshaping tranSition StatEs via transient Strong coupling' (ULYSSES).

assistant: **Concept**

Photochemistry deals with the light-assisted transformation of molecules into useful products. These processes are routinely manipulated by chemical modification and external laser driving. Femtosecond coherent control uses ultrashort pulses to initiate and actively modulate a chemical reaction. However successful control of efficiency and specificity of a chemical process is still awaited.ULYSSES proposes a radical departure from the way chemical processes are currently controlled by light. I will introduce an innovative “transient polaritonic control” for manipulation of photoinduced processes, using polaritons (hybrid light-matter states in strong coupling regime) activated on demand in optical nanocavities. I will exploit tunable resonances in metasurfaces (nanostructure arrays) excited by ultrashort pulses for controlling the energy landscape of molecules. Reconfigurable molecular/metasurface “metacavities” will switch on/off strong coupling for real-time selective reshaping of transition states, that I will apply to the proof-of-principle control of a photoisomerization reaction.The project proposes a paradigm-shift in coherent control through three objectives, combining physical chemistry with ultrafast nanophotonics, which perfectly suit my scientific profile.1) Develop a novel multidimensional “kD Spectroscopy” for characterizing fundamental processes in strongly coupled systems with the unprecedented combination of temporal and momentum resolutions.2) Design and characterize reconfigurable metasurfaces with ultrafast all-optical tuning of resonances to enable transient strong coupling.3) Demonstrate the manipulation of the energy landscape of a photoisomerization by reshaping the transition states via transient strong coupling in a metacavity.I foresee my uniq