RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biological Network Mediated and Transient Liquid Assisted Growth of High Performance Superconducting Tapes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

BioNetTLAG aims at developing an advanced methodology to increase the present performances of high temperature superconductors (HTS) prepared from low-cost chemical solution deposition (CSD) methods and under the fast production speed enabled by transient liquid assisted growth (TLAG), to finally boost the market adoption of this methodology. This would expand the currently niche and expensive HTS market, which would help meet the ambitious renewable energy objectives outlined in the EU Green Deal, the Horizon Europe Missions and the UNESCO goals in a timely manner. The reason why CSD-TLAG is not yet a widespread industrial technique is that it is difficult to control the solution chemistry and the carbon removal during the thermal treatments, in order to avoid secondary phases during the ultra-fast growth, which then limit current percolation in the superconducting film. Thus, its compatibility with thick HTS films on commercial flexible metallic substrates has not yet been proven. BioNetTLAG aims to overcome this limitation by developing a new chemical solution using metal salts of dicarboxylic amino acids. Besides being compatible with greener solvents, their high metal coordination capability per carbon content will create a network of inter-metallic bonds in low-carbon solutions, which will maintain the atomic homogeneity and atomic-level control required throughout the fast growth. Advanced in-situ analyses (looking for the first time at both crystalline and amorphous phases and from deposition to growth) will correlate solution chemistry with electrical properties, while enabling faster optimization of the processing parameters that will lead to higher performances. BioNetTLAG also contributes to the transfer of knowledge of HTS industry experience of the fellow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Thematic network : energy in the built environment (ENERBUILD RTD)' to be submitted under Fifth Framework.

assistant: **Abstract**

The EnerBuild RTD Thematic Network will provide important impetus to the process of bringing about change in the energy efficiency of European buildings by delivering significant added value to EC-funded research. The Network will comprise primarily JOULE and CRAFT building-related energy R&D projects, and FP5projects particularly within Key Action 6. Projects will be grouped incarefully constructed dynamic clusters co-ordinated by internationally respected experts, and considerable emphasis will be accorded inter-cluster opportunities and horizontal dimensions such as socio-economic and other crosscutting objectives at the European level. The entire process will be guided by a formal Steering Committee deciding strategic matters and including senior representatives of European industrial, professional and research federations and associations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Data-Driven Approaches in Computational Mechanics for the Aerohydroelastic Analysis of Offshore Wind Turbines' in the context of a Horizon Europe call.

assistant: **Objectives**

A massive upscaling of offshore wind turbines is necessary to reach the goals of the European Green Deal. However, current methodologies for analysis and design are at their limits. One of the major bottlenecks is that it is so far not possible to directly integrate experimental data into aerohydroelastic simulations of offshore wind turbines. By and large, including these data into the aerohydroelastic analysis is indirectly accomplished through the offline adjustment of those parameters that define instances of existing models. Although such a practice can reasonably improve the short-time predictive capability, the underlying models remain unmodified. Thus, further physics available in the data remains inaccessible. In the numerical simulation context, this represents a main challenge to taking advantage of the experimental data in their entirety. In this context, DATA-DRIVEN OFFSHORE proposes to simultaneously integrate these highly-valuable data into aerohydroelastic simulations through data-driven computational mechanics. Such an approach is one of the most advanced computing frameworks, and relies on the reformulation of classical boundary and initial value problems in solid and fluid mechanics such that constitutive models, boundary conditions and/or applied loads are directly replaced by some form of experimental data. DATA-DRIVEN OFFSHORE will thus enable for the first-time investigation of the aerohydroelastic behavior of an offshore wind turbine relying truly on experimental data, capturing the hidden features that these contain. This will greatly improve the predictive capabilities with respect to existing models, allow the conception of less-conservative designs, and enable upscaling beyond 20 MW of rated power, increasing the efficiency while reducing the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optical and adaptational limits of vision' to be submitted under Seventh Framework.

assistant: **Abstract**

Despite extensive research on the optics of the eye and the neuronal processing of the optical image that is projected on the retina, a number of basic questions are surprisingly unclear. Combining the expertise of 5 University-based European laboratories with a long history of scientific accomplishments, a well established industrial partner, and a high-ranking international advisory board, this training network will provide a platform to train young natural scientists at the interface of physics, optics and biology. Several of the PIs were successfully involved in previous multi-site training activities. Training activities will include complementary skills courses, lab exchanges, external schools and network meetings. The proposed research projects will elucidate the limits of visual performance, using state of the art technology. It has direct implications for optical correction strategies (spectacles, refractive surgery etc), for the understanding how different mono- and polychromatic aberrations limit vision and sensitivity in low light environments. In addition, the research will improve the understanding of the cues that drive accommodation and emmetropization, the mechanisms by which neural processing in the eye can ""sharpen"" degraded, aberrated or defocused retinal images, and how visual performance is affected by diurnal factors. The combination of expertise of the PIs in physics, optics and biology (probably unique in Europe) will provide the young scientists with knowledge that opens the doors to positions in Medical Optics Industry as well as positions in Academia. Furthermore, the young scientists will be extensively exposed to specialists in the field who have well-established contacts to the private sector, opening the door for long-term interactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tools to optimize high speed craft - port interface concepts (TOHPIC)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The difficulty for the High Speed Craft (HSC) to approach, manoeuvre and load or unload safely and efficiently in existing ports causes severe delays in turnaround time. This limits the applicability of HSC. To improve this with regard to manoeuvrability, mooring and terminal system TOHPIC will address controllability, communications and management systems, the shape of mooring interface systems and devices, as well as automatic loading and unloading techniques, and provide harmonised EU standards for sea/shore interface operation, propose new shore to ship interface solutions by integrating port layout, cargo handling and infrastructure concepts, propose effective logistic solutions and provide a simulation tool for optimisation of turnaround and safety conditions. TOHPIC is end-user driven, by major ports, HSC operators and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High Speed Opto-Electronic Memory Systems' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project aims to make the use of board level optical interconnection in information systems practical and economical by developing opto-electronic packaging technology compatible with standard electronic assembly processes. The technology will allow seamless integration of planar free space optics, waveguides and fiber arrays into high performance electronic systems. Thus it will provide information technology systems with high chip IO, high bandwidth and low latency connections needed to solve the interconnection bottleneck.To demonstrate the potential of the technology we will address the most pressing problem of contemporary computer architecture: memory latency. We will implement a fully functional multiprocessor DPS running an industrially motivated application. The optical interconnection will reduce the memory latency of the demonstrator to the range of raw chip latency and signal propagation time.Objectives:1) Develop opto-electronic packaging technology that allows a seamless integration of complex, parallel opto-electronic interconnection with conventional high performance electronic systems using standard electronic assembly techniques;2) Construct a demonstrator to prove that the above technology coupled with a system architecture specifically designed to exploit the advantages of optical interconnection can dramatically increase the performance of real life information systems. To this end we will address the key problem of contemporary computer architecture: memory latency in a system motivated by an industrial application of one of the partners.Work description:1) Opto-Electronic packaging technology: The proposed board level optical interconnection concept is based on the combination of two new optical transmission system: a) Planar free space optics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Linking metabolism and RNA biology in neurodevelopment through a new pathway' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Neurodevelopmental disorders (NDDs) affect 3-8 percent of children across Europe and cause a life-long alteration of cognitive abilities or social interactions with little therapeutic possibilities. Recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in NDDs like intellectual disability and autism spectrum disorder. Notably, neuronal circuit development, a crucial process during the formation of the brain, is characterized by an increase in metabolic activity supporting a period of intense remodelling. However, the knowledge of molecular processes controlling metabolic homeostasis during neural circuit development is still incomplete. We recently defined the autism-associated kinase NUAK1 as a critical regulator of local mitochondrial metabolism in neurons, supporting axon morphogenesis. However it is not clear how NUAK1 controls metabolic processes in neurons. We have identified a novel substrate of NUAK1 and hypothesize that NUAK1 controls an alternative splicing program through this new interactor, thereby regulating metabolism, which in turn affects neuronal development. We will: 1. Perform a phenotypical characterization of the novel substrates role in developing neurons in vitro and in vivo; 2. Investigate its effect on neuronal and axonal metabolism; 3. Characterize its associated transcriptomic signature in developing neurons; and 4. Assess the role of NUAK1 in controlling its novel substrate functionally. For this, we will use state-of-the-art techniques like microfluidic devices and deep-sequencing of mRNA. This ambitious project aspires to describe a new cellular pathway, integrating RNA biology and metabolism in developing neurons and will provide the first characterization of a novel interactor of NUAK1 and its control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'KlotoDx A quick and cost-effective near-patient tool to identify sepsis-related bacteria and antibiotic resistances'.

assistant: **Objectives**

Sepsis is a common disease caused mostly by bacteria that affects about 30 M people each year worldwide. If not diagnosed on time and treated appropriately, it may be lethal in 30% of cases and the cost for the healthcare system if not detected within the first 24 hours can rise dramatically. Current diagnostic techniques used to detect bacteria in patients’ blood, and identify their antimicrobial resistances, are still based on blood culture which takes more than 1 day and has a very limited detection efficiency. Moirai Biodesign is currently engineering a whole new generation of RNA-based diagnostics using both our in-house and cutting-edge artificial intelligence algorithms to detect ribosomal RNA from bacterial agents and expressed bacterial genes associated to common antibiotic resistances and a patient’s blood sample. Our platform is a near-patient, fast, efficient and cost-effective solution for the early detection and characterization of sepsis-related bacteria which will improve patient’s treatment, avoid broad-spectrum antibiotics’ side-effects and dramatically reduce death rates. Our technology has been preliminary validated for the diagnosis of Acute Promyelocytic Leukemia (APL) and KlotoDx’s main goal is to further adapt, validate and commercialize our disruptive diagnosis device for the identification of sepsis-causing bacteria and their antibiotic resistance genes. To achieve it and place our disruptive near-patient solution in the healthcare market, we envision a total investment of around €2.3 M and we plan to reach the 70% (around €1.6M) by applying for a Phase 2 within the H2020 SME-Instrument programme, once we perform the feasibility study during Phase 1. The increasing need for early sepsis diagnosis aand its characterization in terms of antibiotic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrodynamical simulations of protoplanetary discs in the era of ALMA imaging' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This is a proposal for an ambitious programme of state of the art hydrodynamical simulations, designed to answer some key questions about the role of disc self-gravity in planet formation. The programme is also designed so as to maximize the synergy with  the new observational constraints from high resolution imaging data from the Atacama Large Millimetre Array that will become  available  over the  timescale of the grant. The five year programme should provide definitive answers about whether planet formation is able to get going during the early, self-gravitating phase of disc evolution and how, if so, it would affect the further evolution of the disc. The topic of gravitational disc fragmentation as a route to planet formation is currently in a state of crisis, with recent simulations undermining what had become a consensus view on the subject. A dedicated and carefully constructed approach, as detailed here, is required to solve this problem.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A new role for CD44 in carcinogenesis' in the context of a Seventh Framework call.

assistant: **Objectives**

CD44 is a type I transmembrane glycoprotein highly polymorphic expressed in most tissues. The single gene can give rise to many different transcripts, named CD44 variants. CD44 represents the principal receptor for the main matrix glycosaminoglucan component, the hyaluronic acid (Ponta et al., 2003). CD44 is a multifunctional protein involved in lymphocyte homing and activation, cell migration or apoptosis. CD44 functions are modulated by metalloproteases that cleave the extracellular part of CD44, giving rise to a soluble form. The remaining transmembrane part of CD44 can be further cleaved by gamma-secretase resulting in the liberation of the C-terminus tail, called CD44ICD (intracellular domain), which translocates to the nucleus. Although, the functions of CD44ICD are not yet understood, it has been shown that it can potentiate its own transcription in a p300/CBP dependant manner (Okamoto et al., 2001). Recent work from Manié and colleagues has shown that CD44ICD per se possesses a transforming activity which is actively participating in the oncogenesis induced by the oncogenic form of Ret MEN2A (Multiple Endocrine Neoplasia type 2A, characterized by medullary carcinoma in the thyroid), revealing a new function for CD44ICD in tumorigenesis (Pelletier et al., 2006). Interestingly, they also observed that CD44ICD potentiates NF-κB transcriptional activity in the context Ret-MEN2A, which is particularly interesting because NF-κB was shown to be an important mediator of cellular transformation by MEN2A (Ludwig et al., 2001) (unpublished data). Finally the group also detected CD44ICD in several human tumoral tissues including colon carcinoma. Altogether these data suggest a new role for CD44 in carnogenesis. The aim of the present project will be to characterize the mole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a Research Environment for Advanced Modelling of Soft matter' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

DREAMS aims at developing an integrated theoretical-computational approach for the efficient description of linear and non-linear spectroscopies of several classes of organic probes, dispersed in polymeric matrices that range in complexity from simple polyolefins all the way to large biomolecules (proteins and polysaccharides).In order to reach this objective, developments along the following lines are required: (i) elaboration of new theoretical models, to expand the scope of currently available treatments; (ii) definition of specific treatments for intermediate regions / regimes in the context of space- and time-multiscale descriptions; (iii) algorithmic implementation of the developed models / protocols in computational codes and, (iv) their efficient integration allowing for seamless flow of information and easy use by non-specialists.A crucial asset for the success of the planned theoretical-computational developments is represented by an extensive network of solid collaborations with leading experimental groups, that will be involved in the synthesis and characterization of the different chromophore / matrix systems, as well as in the in-depth characterization of their spectroscopic responses. These interactions will thus allow for a stringent and exhaustive validation of the capabilities required of a general and versatile computational tool; at the same time, the experimental groups will make full use of advanced theoretical interpretations in the context of a real-world technological problem.In summary, DREAMS relies on a carefully planned combination of theoretical developments, computational implementations, and interactions with experimentalists, in order to achieve a novel and cutting-edge result, namely to provide the scientific community with a set of com