RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of an integrated, high volume manufacturing process for high value smart cards for the european population of sme moulders' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Traditional manufacturing methods for transaction cards have remained largely unchanged for nearly three decades and lamination still remains the principal manufacturing process. However, the advent of the smart card has seen the emergence of injection moulded card bodies for low to medium volume applications, where greater flexibility and higher precision are required in the manufacturing process. There are more than 2000 SME injection moulders in the EU. In common with all injection moulders, involved in the supply chains to the big four European smart card system vendors ( Gemplus, Bull, GPT Axxicon and Siemens ), the Prime Proposer currently moulds card bodies for low value, contact operation smart cards, such as 'phone cards'. However, we have identified the urgent need for a new manufacturing process, based on an injection moulded card, in which the antenna, chip module, or even the die itself, is integrated with the card body and it's decoration, within the moulding process, through the use of in-mould labeling (IML). The current low volume and expensive method of manufacture for these cards is based on a sheet laminating process carried out on high capital plant by the system vendors themselves. As the 'Combi Smart Card' becomes dominant in the market, replacing the currently dominant injection moulded 'phone card' type of smart card, European SME moulders within the smart card supply chains will lose their existing business and fail to benefit from the massive market growth predicted for smart cards as a whole. The current smart card market is reported to be around 1 bn units pa, with an annual compound growth rate of between between 30% and 50%. Appendix 1 outlines the various product types and their features. Both SGS Thompson (the leading chip manufacturer)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Statistics of Fractionally Charged Quasi-Particles'.

assistant: **Concept**

The discovery of the fractional quantum Hall effect created a revolution in solid state research by introducing a new state of matter resulting from strong electron interactions.  The new state is characterized by excitations (quasi-particles) that carry fractional charge, which are expected to obey fractional statistics.  While odd denominator fractional states are expected to have an abelian statistics, the newly discovered 5/2 even denominator fractional state is expected to have a non-abelian statistics.  Moreover, a large number of emerging proposals predict that the latter state can be employed for topological quantum computing ( Station Q  was founded by Microsoft Corp. in order to pursue this goal).  This proposal aims at studying the abelian and non-abelian fractional charges, and in particular to observe their peculiar statistics.  While charges are preferably determined by measuring quantum shot noise, their statistics must be determined via interference experiments,  where one particle goes around another.  The experiments are very demanding since the even denominator fractions turn to be very fragile and thus can be observed only in the purest possible two dimensional electron gas and at the lowest temperatures.  While until very recently such high quality samples were available only by a single grower (in the USA), we have the capability now to grow extremely pure samples with profound even denominator states.  As will be detailed in the proposal, we have all the necessary tools to study charge and statistics of these fascinating excitations, due to our experience in crystal growth, shot noise and interferometry measurements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nano-carbon based components and materials for high frequency electronics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A strong expansion of the frequency range towards terahertz and infrared is the major trend in the modern electronics and optoelectronics. It relies on the incorporation of modern nanotechnology that has already given the birth to nanoelectronics, a rapidly developing discipline focused on both the dramatic increase of the component integration level and decrease in a power consumption. Performance of nanoelectronic devices is strongly influenced by quantum effects that often even determine properties of nano-sized components. The project aims at understanding of fundamentals of the electromagnetic processes in nanocircuits, theoretical and experimental investigation of underlying mechanisms responsible for their fascinating properties, and development of physical basis for use of these properties in novel nanoelectronic devices. The project focuses on linear and nonlinear electromagnetic effects in nano-carbon structures, such as onion-like carbon and both single- and multi-wall carbon nanotubes. We will investigate in detail a performance of nanocircuits based on carbon nanotubes and other nanocarbon materials. The multidisciplinary and challenging project relies on the complementary expertise of the consortium teams and is based on the original approach combining electrodynamics of mesoscopic inhomogeneous media and quantum theory of electronic ensembles with reduced dimensionality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reinforcement of tolerance to myelin antigens, a preclinical study in the common marmoset model of autoimmune encephalomyelitis' (MOG-DC-SIGN).

assistant: **Concept**

The autoimmune disease sclerosis multiple (MS) induces neuronal demyelinitation caused among others by autoantibodies. A significant proportion of them are directed against the myelin/oligodendrocyte glycoprotein (MOG). The suppression of anti-MOG autoimmunity should be an essential component of a therapy for MS. Common marmoset provide us a unique pre-clinical model due to its high similarity to human and the resemblance of marmoset experimental autoimmune encephalitis (EAE) to MS. Immature dendritic cells (DC) control peripheral tolerance to self antigens through the balance between the signals provided by ligands of their C-type lectins receptors (CLR) and Toll-like receptors (TLR). The disturbed glycosylation of MOG derange the union to CLR and promote autoimmune reaction. Targeting properly glycosilated MOG to CLR, tolerance antigen specific can be induced.The native or tailor-made glycosylated recombinant marmoset MOG (rmMOGgly) will be used for tolerization, whereas unglycosylated MOG (rmMOG) will be used for EAE induction. We will preferentially focus on the specific CLR DC-SIGN, expressed in immature DC. Tolerance to rmMOGgly would be promoted by preventing the DC maturation. As a main consequence, marmosets immunized with rmMOGgly would be protected to EAE disease in this pre-clinical model. Working in the proposed project will contribute to my professional growth since I will gain access to applied science when my previous research experience was mainly based on basic science. It is also a challenge to work in Molecular Biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'EDSCIENCE2011- ITALY PLAYS SCIENCE'.

assistant: **Concept**

The 23rd of September 2011 the “Everyday Science 2011. Italy plays Science” project organises RN events in 15 Italian towns distributed in 10 regions from North to South of the nation: Bologna, Ferrara, Piacenza, Faenza (EMILIA-ROMAGNA), Pavia (LOMBARDIA), Lerici-La Spezia (LIGURIA), Padova, Verona (VENETO), Pisa (TOSCANA), Napoli Capodimonte, Salerno (CAMPANIA), Cosenza (CALABRIA), Catania (Sicilia), Cagliari (Sardegna).The aim is to make researchers’ work and experience closer to general public and offer an unusual amusement alternative for the Friday night by playing with science thought different perspectives. Researchers are involved in live hands-on, short labs, games, music and talk shows, together with artists and musicians. In 2011 events are more focused on presenting researchers’ work and experience thought art performances, amusing challenges and games. Synergy with national celebrations of 150° anniversary of the Italian Unity is foreseen, by organizing ad hoc initiatives with researchers and scientists. Live web-tv and web-radio broadcast from Bologna, with links with all project events and with other Researchers’ Night in Italy.National communication campaign is mainly based on web social media (blog, facebook, twitter) and channels (web tv and radio). Synergies on communication strategies are planned with other Italian funded projects.After the two successful editions in Emilia-Romagna (2009, 2010), “Everyday Science 2011” project enlarges its capacity to involve research centres, universities and media partners at national level. “Italy plays Science” is the new subtitle which underlines this wider geographical approach. 7 universities, 4 national research institutes and 2 national media partners compose the partnership, coordinated by ASTER (consortium
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A demonstration plant of enhanced biogas production with Add-On technology' (ADD-ON).

assistant: **Innovation**

The overall goal of the business innovation project is to commercialise Ductor’s proprietary nitrogen-control technology that has the potential to revolutionise the economics of biogas production. Our technology, based on cumulative R&D investment of over 4 m€, is capable to remove over 60% of nitrogen from several organic waste materials. This enables broader utilisation of high-nitrogen organic waste such as chicken manure in biogas production, which allows millions of tons of unexploited organic waste in Europe to be processed cleanly, economically and efficiently. Via Ductor’s technology, biogas producers can, for example, increasingly replace maize silage with chicken manure as biogas feedstock. With this approach alone, the European biogas producers could achieve a combined +1 b€ improvement in their profitability while also cutting CO2 emissions by 1.5 million tons and releasing 811,000 hectares of field for socially and environmentally more sustainable use such as food production. During the project, we will scale up our current pilot equipment to industrial scale together with our partner, a  European biogas producer. We will also confirm the expected benefits of our technology in industrial environment and optimise the technology for a broad range of feedstocks to cater all customer needs. The project will enable fast commercialisation of our product within the first targeted customer group: the existing small and mid-sized biogas plants in Germany, the largest biogas market in the world. Within this segment, our primary targets are appr. 2,000 biogas plants that currently utilise maize silage in biogas production. Confirming our value proposition in this customer group enables us to develop our technology to meet the requirements of larger biogas plants as we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeted delivery of charged membrane impermeant compounds to pain-sensing and cancer cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Targeted delivery of therapeutic compounds to selective cell types is of great clinical importance and can minimize undesired side effects. Recently, we have introduced a way to target the delivery of sodium channel blockers selectively to nociceptive neurons, and thus capitalize on their effectiveness in blocking action potentials but now only at sites of pain generation. Using this approach we have been able to abolish the response to noxious mechanical and thermal stimuli without motor or tactile deficit (Binshtok et al., Nature).  This approach represents a novel concept of targeted delivery and can be used to block activity and also to modulate intracellular signal transduction and metabolism pathways in pain- sensing neurons a well as cancer or any other large cation non-selective channels-expressing cells, while minimizing effects on other types of cells.  We now need further explore the utility of this technique for clinical use as an analgesic and also see if the strategy can be used in more generalized way to targeted delivery of charger compounds, beyond charged local anesthetics, to specific types of cells.This project aims to develop methods for targeted delivery of charged local anesthetics to diminish inflammatory, postoperative and neuropathic pain. The second part of this project will be to examine different strategies to expand the approach to selectively target charged cytotoxic or antiproliferative compounds into cancer cells. This interdisciplinary project will incorporate imaging techniques and electrophysiological, histological and behavioral experiments. We believe that the results of our work will lead to a more effective treatment of pain with significantly fewer side effects.  Furthermore targeted delivery of chemotherapeutic agents into tumor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Replication initiation proteins as new targets for bacterial growth inhibition'.

assistant: **Objectives**

There is an urgent need for the discovery of novel antibacterial compounds to combat deadly emulate-drug resistant strains. Our targets are the proteins of initiation of DNA replication (IDR).Since they differ substantially in bacteria and eucalypts the bacterial IDR proteins constitute unattractive and unexplored family of targets for development of new antibiotics which is the essence of our proposal. The novelty of this approach lies in the development of assays to highlight the inhibition of IDR proteins and in the identification and/or design of compounds, which target IDRproteins. Our objective is to engineer bacterial strains for in vivo screening and in vitro biochemical detection methods for the identification of novel inhibitors of DNA replication initiation. High-throughput screening (HTS) and detailed structure-activity knowledge of the IDR protein inhibitors will bemused for synthetic modifications to enhance the specificity of targeting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced personalised, multi-scale computer models preventing OsteoArthritis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Osteoarthritis (OA) is a degenerative disease of the articular cartilage and the most common form of arthritis that causes joint pain, mobility limitation and, thus, reduces independence and overall quality of life. Although the usual population associated with the condition is the elderly (65 years old ranges from 12- 30%), who are mostly inactive, athletes and younger individuals are also susceptible. Whilst the available data have implicated the role of the various modifiable or non-modifiable risk factors in the development and progression of OA, no study has conclusively explored the interaction and integration of other information sets in a patient-specific manner. The current OACTIVE project intents to make a significant leap forward adopting a multi-scale holistic approach where patient-specific information from various levels, including cell, tissue, organ and whole body will be integrated and combined with information from other sources such as biochemical/inflammatory biomarkers, behaviour modeling and social/environmental risk factors to generate robust predictors for new personalised interventions for delaying onset and slowing down progression of OA. OACTIVE targets to patient-specific OA prediction and interventions by using a combination of mechanistic, phenomenological computational models, simulations and big data analytics. Once constructed, these models will be used to simulate and predict optimal treatments, better diagnostics, and improved patient outcomes. Overcoming the limitation of the current treatment interventions, Augmented Reality empowered interventions will be developed in a personalised framework allowing patients experience the treatment as more enjoyable, resulting in greater motivation, engagement, and training adherence. OACTIVE’s m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural investigations of Bacterial Secretion by Solid-State NMR', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Many cellular processes rely on multi-functional molecular nanomachines, such as the ribosome (protein synthesis), bacterial pili and needles (host-pathogen interaction) or flagella (cell motion). These machines are built by the assembly of multiple copies of protein subunits into large macromolecular structures, also called supramolecular assemblies. Understanding assembly, structure and functions of these machines is hampered by the challenging structural characterization task. Indeed, these insoluble and non-crystalline objects are not amenable to high-resolution X-ray crystallography or solution NMR. Solid-state NMR (SSNMR) can provide atomic details about structure and dynamics of biological assemblies. Notably, the first atomic models of a prion in its fibrillar form (the prion domain of HET-s, see Wasmer et al., Science 2008) and a bacterial filament (the Type III Secretion System needle, see Loquet et al., Nature 2012) were established on the basis of SSNMR restraints.The Type II Secretion System (T2SS) is a complex machinery found in Gram-negative bacteria, designed to transport effector proteins from the bacterial periplasm to the extracellular space. T2SSs contain a periplasmic filament, called the pseudopilus, that organizes the secretion of the T2SS exoenzyme through the outer membrane. The pseudopilus is built by multiple copies of a single polypeptide subunit, forming an insoluble and non-crystalline macromolecular assembly. In this project, I propose to use SSNMR to solve the structure of the T2SS pseudopilus in its relevant assembled state, as well as to shed light on the specific interactions with its exoenzyme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Financial Imperfections and Macroeconomic Implications' in the context of a Seventh Framework call.

assistant: **Objectives**

We plan to study the implications of financial market imperfections for four main questions.First, how do financial imperfections affect the optimal conduct of monetary and exchange rate policy in open economies? A key insight is that we characterize financial frictions as endogenous and only occasionally binding. This can have important implications for the optimal conduct of stabilization policy.Second, how do financial and labor market imperfections interact?  We extend the standard search-and-matching model to allow firms to issue debt. This feature affects the wage bargaining process endogenously, since firms, by leveraging, can pay lower wages. We study the ability of such a model to replicate the volatility and persistence of unemployment in the data, and the role of financial imperfections in affecting the transmission of productivity and financial shocks.Third, does the effectiveness of tax policy depend on its redistributive content, and how is this affected by financial imperfections? We characterize the distributional feature of several Tax Acts in the US, and investigate empirically whether tax changes that “favor the poor” are more expansionary than cuts that “favor the rich”. We then build a theoretical framework with heterogeneous agents and financial frictions to rationalize our evidence.Fourth, how do financial intermediaries affect the transmission channel of monetary policy? We extend the current New Keynesian framework for monetary policy analysis to study the role of financial intermediaries. We emphasize the role of three features: (i) asymmetric information in interbank markets; (ii) maturity mismatch in the banks’ balance sheets; (iii) the “paradox of securitization”, thereby a deeper diversification of idiosyncratic risk leads to a simultaneous