RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New therapeutic approaches to osteoporosis: targeting the osteoclast v-atpase' in the context of a Fifth Framework call.

assistant: **Objectives**

By harnessing the different skills of a multidisciplinary consortium, it is proposed to develop chemical and immunotherapeutic approaches directed towards inhibition of the osteoclast vacuolar ATPase. Specifically, this protein complex is responsible for the acidification process vital to bone resorption. Its inhibition will be a major contribution to combating osteoporosis, a very major problem in the aging population. The experimental strategy will draw upon(i) the unique location of the enzyme in the plasma membrane of this cell-type and(ii) the presence of natural inhibitors of the protein. The project will involve novel chemical synthesis, analysis of the functional effects of chemical agents and antibodies, structural analysis of the targeted subunits of the complex to determine drug interactions and testing of potential leads in in-vivo animal systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Physiology of Nutrient Sensing by mTOR' (NutrientSensingVivo).

assistant: **Concept**

A major role of metabolic alterations in the development of several human diseases, as diabetes, cancer and in the onset of ageing is becoming increasingly evident. This has a deep impact for human health due to the alarming increase in nutrient intake and obesity in the last decades. Fundamental aspects of how aberrant nutrient fluctuations trigger deregulated hormone levels and endocrine signals have been elucidated, being a prime example the phenomenon of insulin resistance. In contrast, how changes in nutrient levels elicit direct cell-autonomous signal transduction cascades and the consequences of these responses in physiology are less clear.The signalling circuitry of direct nutrient sensing converges with that of hormones in the regulation of the mechanistic target of rapamycin (mTOR) kinase, a driver of anabolism, cell growth and proliferation. Deregulation of mTORC1 activity underlies the pathogenesis of cancer and diabetes, and its inhibitor rapamycin is approved as an anti-cancer agent and delays ageing from yeast to mammals. In spite of its importance for human disease, our understanding of the nutrient sensing signalling pathway and its impact in physiology is largely incomplete, as only a few years ago the direct molecular link between nutrients and mTORC1 activation, the Rag GTPases, were identified.The present proposal aims to determine how the nutrient sensing signalling pathway affects mammalian physiology and metabolism, and whether its deregulation contributes to cancer, insulin resistance and aging. In particular, the objectives are: 1) To identify novel regulators of the Rag GTPases with unbiased and candidate-based approaches. 2) To establish the consequences of deregulated nutrient-dependent activation of mTORC1 in physiology, by means of genetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring the diet-microbiota axis for immunomodulation and organ protection in hypertension' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Essential hypertension damages organs such as the kidney, thereby leading to premature death. Beyond elevated blood pressure, hypertension is characterized by a pro-inflammatory immune response ahead of measurable organ damage. Activated immune cells infiltrate the kidney to cause tissue injury. However, inflammation is insufficiently addressed by todays drugs. Current treatments do not include the gut microbiota, its metabolites and the associated lymphoid tissue  the largest immune cell reservoir in the body. We have recently shown for the first time that variations in dietary salt intake promote hypertension by modulating the immune system via the microbiota and its metabolites. Thus, the diet-microbiota axis is an important modulator of the immune response in hypertension. HyperBiota envisions a personalized, microbiome-guided immunonutrition for anti-inflammatory immunomodulation and organ protection in hypertension. It will explore the interplay between diet-dependent microbial metabolism in the intestine and the immune system in hypertension. By using an interdisciplinary approach, HyperBiota aims to 1) decipher the reciprocity of dietary composition, microbial community structure and metabolism, and immune response in hypertension. The identification of critical dietary and microbial components will enable targeted interventions. 2) Particular attention will be payed to worsening kidney function and how this affects microbial ecology and immune cell homeostasis. 3) It will investigate the extent to which the gut-associated lymphoid tissue contributes to the immune response in hypertension and its responsiveness to targeted interventions. 4) Knowledge gained in model systems will be translated and verified in mice associated with human microbial communities. Taki
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Improved behaviour laws including ductility criteria for forming processes', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The research is proposed by Ledepp. 200-people work in the Ledepp (R&D laboratory of the Steelmaker Usinor Group). Four main R&D objectives which provide a strategic fit with Usinor's corporate objectives: Develop new products and services meeting our customer's needs; identify new applications for our steels; Offer customers comprehensive steel solutions (help in choosing and using products, ensuring safe use, etc.); Enhance industrial performance (improve current production processes, develop new processes, improve product quality, etc.). Candidates from Eastern European Countries would be highly appreciated. You will be associated with the existing project. In the simulation's domain of forming processes, we propose to improve the behavior laws of steel sheet through the implementation in the FEA codes of new laws with ductility criteria followed by numerical and experimental validation in deep drawing and rheological tests. Our proposal aims at obtaining a better FE simulation of the steel sheet forming processes, through three main steps:1 - Development of an effective implementation of rich, up-to-date material models, together with the required parameter identification technique;2- Intensive numerical and experimental investigation of a selected range of materials and test procedures (especially two strain-path mechanical tests);3-Improvement of the model features which are poorly validated. Thus, the work for fellows about this project includes several tasks: numerical implementation, parameters' identification, FE simulations for validation with compare experimental measures. The knowledge or capabilities requested for the work are : FEA Code as Abaqus or Pamstamp; Fortran language; general knowledge in mechanic continuum medium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Procurers Platform - eHealth  - Transforming the market for eHealth Solutions' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Public Procurement of Innovation (PPI) is a crucial challenge for public bodies to be implemented during next years. The “usual” way of purchasing goods is based solely on the price of the product. Life cycle costing, supply chain analysis or group purchase are rarely used, which means missing some opportunities to get innovative products that would give purchasers competitive advantage. Therefore, there is an urgent need to start developing networks of procurers. Such networks will enable them to identify common needs, conduct market analysis, understand supply chain, use these tools to comprise a higher procurement volume, and achieve bigger impact on suppliers. It will allow them voice out their unmet needs, create a new demand to access sustainable products of higher quality, and develop new applications with lower life cycle costs. This can be obtained through PPI.Information and Communication Technologies (ICT) has equally become an essential tool used in nearly all areas of society. Health sector, which is the core of this proposal, is no exception to this regard. The target of the project is to understand health care public procurers unmet needs, particularly in eHealth. That is why a network of procurers will be developed within the scope of the project. The network will allow the consortium to identify common needs, explore the best available solutions and stimulate the market with the aim of creating a PPI/PCP procurement strategy for the eHealth sector. In order for the EPP-eHealth consortium to be able to achieve the mentioned objectives, a set of 4 workshops aimed at project members and potential stakeholders will be developed. Three of these workshops will train attendees in public procurement while a 4th workshop will be used as a market test. Finally an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Liquid Membranes and Ionic Liquids for Selective Downstream Processing' (LIQUIMEM), addressing dissemination and exploitation.

assistant: **Impact**

Downstream processing is still one of the major challenges not only for chemical and biotechnological production processes, but also for wastewater treatment. Very often the treatment of aqueous process streams, which typically are obtained from biotransformations or from wastewater treatment, is necessary for the removal of either hydrophobic or hydrophilic compounds, which may be present at various concentration levels. The present proposal aims to combine recent developments in the field of membrane technology such as nanofiltration, liquid membranes or pervaporation with the use of ionic liquids for providing novel solutions for downstream processing or process intensification. The major objective of the project is to investigate the development and application of supported liquid membranes on the base of ionic liquids. When using liquid membranes the selectivity of the separation is not based on the solid support of a given membrane, but on the properties of the liquid. Liquid membranes offer a range of possible advantages, such as better control of the selectivity.The compounds to be separated may be products of biotransformations and fermentation processes or renewable materials. Compounds of interest are carbohydrates, chiral alcohols and amines and more complex metabolites, such as antibiotics. The potential of these new types of liquid membranes will also be tested for e.g. extraction of heavy metals from aqueous streams (wastewater). The potential of ionic liquids in combination with pervaporation shall be explored. First results indicate that volatile compounds can be removed from ionic liquids by pervaporation. Due to their negligible vapour pressure and relatively high viscosity ionic liquids may be used as pervaporation membranes. Together with the tunabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decoding endothelial cell BEhavioral MOSAICism within single vessels' (BEMOSAIC) targeting Horizon Europe.

assistant: **Abstract**

Endothelial cells (ECs) form a dynamic monolayer lining the lumen of vessels. While single-cell data have revealed high degrees of heterogeneity amongst ECs at the inter- and intra-organ levels, the prevailing notion has long been that vessels themselves are composed of largely similar ECs.  Instead, data from our labs challenge this view by showing that vessels are built of highly diverse ECs displaying different behavioral properties, a feature we term intravessel EC behavioral mosaicism. While these findings are promising, there is still much to learn about the range of behavioral variability among ECs within vessels and how this intricate mosaic of behaviors is orchestrated to optimize vascular function. Building on our past achievements, we now aim towards novel directions- to push forward a fresh conception of vessels, as mosaic composites of specialized ECs. Here, we will integrate our synergistic expertise in live imaging, sophisticated genetic approaches, and spatial omics to map EC behaviors in zebrafish and mice. In addition, we will harness oncogenic mutations causing vascular malformations in humans to investigate how they alter the behavioral map. Finally, we will decode mechanisms of vessel tolerance and co-optation in response to stochastic expression of mutations to understand how vessels cope with EC mosaic behaviors. The important and unique aspects of our approach are the focus on in vivo dynamics and the cross-animal and organ comparisons, which will provide much needed knowledge on vessel architecture and function, making substantial advances at the frontier of vascular biology. Overall, we envision that shifting the paradigm of vessel heterogeneity to behavioral mosaicism will provide a better understanding of vascular-related pathologies and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Empowering the micro-array-based European research area to take a lead in development and exploitation' (EMERALD).

assistant: **Concept**

Microarray-based functional genomics technology suffers from a lack of standards and a severe fragmentation. We aim to establish and disseminate quality metrics, microarray standards and best laboratory practices (quality assurance and quality control) thoughout the European microarray community. We will analyse quality control metrics on existing microarray data, and add Normalisation and Transformation ontology to MGED to allow a structured recording of data pre-processing. European efforts to assess the merits of hybridisation standards for QC will be coordinated, and procedures to certify selected standards as European Reference Material will be set in motion. We will unite the different microarray technology stakeholders in a series of topical workshops to address  the development and implementation of QA/QC in research, service, diagnostics, data pre-processing and archiving, computational datamining, new technology development and its exploitation, and to acquire a wide community acceptance and government approval of 'best practices'. We will assess the spectrum of best laboratory practices (standards, protocols, procedures), and discuss how common denominators can be established to standardise QA in varous experimental settings and applications. In a pilot implementation of QA/QC we will assess the impact on data quality and coherence. A web portal at EBI will present a wide network of contacts, and serve to disseminate protocols, data sets, control material, etc. We will assist individual microarray users in their transfer to such common practices. The results and experiences from transcriptome microarray QA/QC will create a cornerstone for a systems biology based life science, and cross-fertilise and advance the maturation process of emerging applications of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Soft Matter at Aqueous Interfaces'.

assistant: **Objectives**

Soft nanotechnology is generally considered as a field that will have a major impact on technological developments in near future. However, the fundamental understanding of the wealth of new structures lacks far behind, despite supporting activity from material science. Such an understanding is indispensable for sustainable growth of this important research domain and its applications. A physics-oriented interdisciplinary education is urgently needed to guide young researchers to the point where they can tackle the relevant fundamental questions. SOMATAI is set up to provide just such training by combining two distinct scientific fields: Soft matter science is a well established interdisciplinary field for the bulk investigation of polymers, colloids, and liquid crystals with response amplitude and time to external stimuli as a function of soft matter structure being of special interest. The second highly relevant field is interface science, since nano-structured materials contain a huge area of internal interfaces which have an essential impact on material properties. The application of the soft matter approach to interfaces promises new and deeper understanding of interfacial phenomena. Interfaces of a water phase to a solid, liquid or gaseous second phase are of special interest and a focal point of SOMATAI. Such interfaces are highly relevant to products from European industry (food, cosmetics, paints) and processes (washing, coating, water purification). They have an outstanding importance from a scientific point of view due to specific interactions at such interfaces. This carefully planned teaching and research programme in a network of 10 leading academic partners, 1 large scale companies, 2 SMEs, and 4 top-level associated partners from Germany, Taiwan and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DynaTweezers: Elucidating the Molecular Mechanisms of Bacterial Gene Silencing using  Tethered Particles and Optical Tweezing' (DynaTweezers).

assistant: **Innovation**

Antimicrobial-resistance is a growing concern in modern medicine. The spread of antibiotic resistant genes, both within bacteria species and between species, is greatly accelerated by horizontal gene-transfer. In intestinal bacteria, a major pool of antimicrobial resistance, the impact of foreign acquired DNA is modulated by H-NS proteins that recognize and silence its expression. I propose to investigate the molecular mechanism of gene silencing by H-NS and related co-regulatory proteins at a single molecular level. With the understanding of the underlying mechanisms, we may enable the development of medicines that revert or suppress the expression of antimicrobial-resistant genes.I plan to investigate the silencing mechanism of H-NS using a combination of dynamic Tethered Particle Motion and axial Optical Tweezers. These techniques allow me to characterize the repeated transcription of individual DNA strands in high detail under a variety of external conditions and under applied forces. Using these techniques, I can systematically study how transcription is affected by stalling of the transcription complex, loop formation and promotor occlusion. My experience in biophysical measurement techniques, in combination with the high performance optical tweezer expertise and an established network of H-NS research in Toronto enable the proposed research in a unique and powerful way.