RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Translational Cancer Faster Forward postdoctoral programme – CanFaster-ER' (CanFaster-Postdoc), addressing dissemination and exploitation.

assistant: **Impact**

CanFaster is a joint venture among industry, health care and academia to enhance and accelerate innovations and clinical implementation within oncology. The mission of CanFaster is to prolong and save lives of cancer patients through integrated development and commercialization/implementation of diagnostic/treatment alternatives, thus reaching the market and patient more rapidly. CanFaster will save lives of cancer patients, not for future generations, but for today´s. The CanFaster programme is enabled by an intimate collaboration between industry, health care system and academia, and will contribute to the Europe 2020 strategy, where one million new research jobs are needed to reach the Innovation Union flagship initiative. The aim of the present proposal for funding is to accelerate this process further by recruiting ERs to synergize with the already ongoing CanFaster doctoral programme. The collected track record of all partners demonstrates an impressive history of entrepreneurial spirit, state-of the art medical care but also truly world-class scientific excellence within translational cancer research. The proposed programme recruting 15 ERs, will be hosted within CREATE Health, a translational cancer research programme with broad international collaboration partners and excellent out-put for the last 12 years. Main objectives of CanFaster are (i) Increased transnational and intersectorial mobility (ii) Intersectorial improvements through intensified collaboration within oncology between academia, industry and hospital/regional health care organisations. (iii) Acceleration of innovation, attracting international investors leading to increased number of SMEs in the region and (iv) Education of a new generation of excellent multidisciplinary, entrepreneurial scienti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A new tool in drug development: mapping of compound-protein interaction using forward genetics'.

assistant: **Objectives**

Development of new medicines such as chemotherapeutic drugs requires a detailed understanding of their biological mechanism of action. What are the desired and undesired interactions with biological molecules? It is our goal to found a start-up company that will provide a solution to this challenge. Using novel and ground-breaking approaches we can identify target structures and interaction partners of small bioactive molecules at an unmatched and unprecedented resolution. ERC PoC funding will be essential to support our activities to identify optimal strategies and initial customers for our service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Collaborative Project on European Sodium Fast Reactor' to be submitted under Seventh Framework.

assistant: **Abstract**

The suggested Collaborative Project (CP) addresses key viability and performance issues to support the development of a fourth generation European Sodium Fast Reactor (ESFR). This innovative system is mainly developed for competitive electricity generation and offer interesting potential characteristics in terms of safety, environmental impact, resource utilisation  and waste minimisation (e.g. potential for Minor Actinides management).  The objectives of the CP-ESFR look for the improvement, vis-à-vis of current nuclear systems, of the safety level, the guarantee of a financial risk comparable to that of the other means of energy production and a flexible and robust management of the nuclear materials. The corresponding technical requirements in terms of System’s performance; Operation, maintenance and procedures; Safety design & analysis and licensing issues; Physical protection &Proliferation resistance; Functional requirements for provisions; Fuel cycle Constructability; Decommisioning; System’s economy are based – among others - upon the results of the 6th FP Specific Support Action EISOFAR (Roadmap for a European Innovative SOdium cooled FAst Reactor). The schedule for this four years project fit with the principle for an industrial deployment of ESFR technology around 2040 with the preliminary deployment of a demonstrator by 2020-2025.   Following the requirements above, and considering the context as it is described, the Collaborative Project is tentatively structured into six main technical sub projects (SPs):  1)Consistency and assessment & international relationships 2)Fuel, fuel element, core & fuel cycle 3)Safety and Security 4)Energy Conversion System Components & materials 5)Reactor system (including handling) 6)Education & training A specific Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Breakthrough Regulatory Innovation and Development throuGh sandbox Environments' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

BRIDGE aims to enhance healthcare innovation in Europe by developing a comprehensive framework for designing and operationalizing regulatory sandboxes. By addressing current regulatory limitations and engaging all stakeholders while ensuring compliance, the project seeks to create adaptable, fit-for-purpose methodologies that strengthen the regulatory ecosystem's capacity to promote healthcare innovation.The project’s objectives include identifying and analysing existing regulatory sandboxes across various domains and maturity levels, to determine how their modules can complement current healthcare regulations. BRIDGE will develop a horizon scanning methodology to continuously identify emerging technologies that challenge existing regulatory systems, analyzing their requirements for potential inclusion in regulatory sandboxes to ensure adaptability within an evolving innovation ecosystem.Through multi-stakeholder consultations, BRIDGE will elaborate and assess case studies, as well as develop operational checklists for module design and evidence packages to guide tailored sandbox launches. The project will also develop the Modular Operational Sandbox for Healthcare Innovation and Compliance (MOSAIC), an architectural model with interconnected modules featuring detailed functional specifications and mapped information flows aligned with specific case studies.Additionally, BRIDGE will engage key stakeholders—including regulatory bodies, industry consortia, HTA bodies, payers, healthcare providers, and patients—in an in-depth analysis, consultation, and consensus-building process to ensure the sandbox approach is comprehensive, functional, and adaptable to future advancements. Finally, the project will deliver comprehensive recommendations for the sandbox methodology’s end
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Commercial feasibility of non-pathogenic Clostridium-Mediated Cancer Immunotherapy:  leveraging the presence of tumour hypoxia & necrosis' under Horizon 2020.

assistant: **Concept**

Immunotherapeutic strategies are powerful weapons in combating malignancies. However, only a minority of patients benefit from this therapeutic modality, as tumours develop mechanisms of immune escape and suppression and uptake of (antibody-based) agents in tumors is limited. The urgency of investigating novel strategic approaches is dictated by the high incidence and mortality rates of cancer worldwide. Lung cancer, in particular, is the leading cancer with respect to incidence and mortality (14% of new cancers).In the ERC Advanced “HYPOXIMMUNO”, Prof. Lambin and his team have investigated the trimodal therapy involving high precision Stereotactic Radiotherapy, hypoxia/necrosis targeting and tumour specific immunotherapy (immunocytokine L19-IL2 to “push the accelerator” with a checkpoint inhibitor to “release the break”). Despite promising results, the delivery of immunotherapeutics to the tumour site has proven to be challenging. Prof. Lambin and his team have sought to overcome this limitation with the inclusion of genetically-modified Clostridium bacteria as optimal delivery system capable of effectively delivering immunotherapeutics within the tumour. These Clostridium-bacteria selectively colonise the hypoxic/necrotic regions present in solid tumours and act as cellular factories capable of continuously producing tumour-specific immunotherapies within the tumour (watch https://vimeo.com/251022032 ).In this ERC PoC project, a team of technological and commercial experts will investigate the commercial feasibility of this innovative approach. We will prepare the first steps towards the start-up of a spin-off, by defining the exact business strategy, model and positioning for commercial success. We will develop the business strategy based on the technological aspects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REQUIREMENTS ENGINEERING AND SPECIFICATION IN TELEMATICS' to be submitted under Fourth Framework.

assistant: **Abstract**

The main purpose of RESPECT is to provide the EU telematics projects with a methodology for specification of user requirements so that these can be comprehensively identified and defined. A second objective is to consolidate existing methods for the specification of user needs and the capacity for use into a framework and procedural methodology. Cost-effective methods will be selected from industry, and applicable to general and special user groups. Both objectives will be achieved by means of a methodology handbook, joint meetings, feedback from selected projects for methods validation and project consultancy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'CReating Innovative Sustainability Pathways', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The core objective of this proposal is to identify potential paths to engaging on an integrated effort to support the transition, to a sustainable, low carbon Europe. The call text places much emphasis of using a scenario and backcasting approach that explicitly discerns individuals, organisations and the collective (societal and economic organisation), addresses the interaction of agency and structure, and analyses from there how individuals and collectives can be engaged on sustainable paths, and how new policy mixes and co-operation mechanisms can overcome barriers to change. In response, this project will:•build upon theories that explicitly link individual and organizational agency with structure and pathways of change (most notably Transition theory, that builds upon structuration and innovation theories) (WP1).•analyse practical (past) cases of change with this framework (WP2 and WP3) to additional understanding on the role of agency and structure and related barriers, drivers and pathways of change (WP4).•apply novel participatory scenario techniques, most notably transition scenario and backcasting methodologies, to develop sustainability visions WP5) and transition paths (WP6). These allow for specific analysis of processes in transition paths and the factors that drive and hinder such transitions (WP7).•Finally, on the basis of the analysis of the theoretical basis and cases (WP4) and the results of the scenario/backcasting exercise (WP7), the core question of the call can be answered (WP8): what novel policy mixes and co-operation mechanisms can help to overcome barriers for individuals and collectives to engage on sustainable paths.The project is completed by WPs on Management and Dissemination. The impact of the findings of the project is enhanced by its s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BIONIC FEEDBACK SYSTEM FOR AMPUTEES AND DIABETICS' to be submitted under Horizon 2020.

assistant: **Abstract**

The BIONIC FEEDBACK SYSTEM. The Austrian company SAPHENUS Medical Technology, founded in 2016, has set itselfthe goal of improving the quality of people who lack the feeling in the legs, whether through polyneuropathy or throughamputation. 1,5 million amputees and 7,5 million people with polyneuropathy and serious sensory problems are affected allover Europe. For these two target groups SAPHENUS has the breakthrough solution using the bionic principle. With theBionic Feedback System (BFS) the affected persons get back the feeling of the lost or damaged foot, they feel authenticagain, and the brain is provided with sensory information again. SURALIS and CUTANEUS, the two BFS-products of SAPHENUSare patented high-tec add-on devices that consist of (i) a sensor sole and (ii) a transmission part which is applied on thestump or leg. SURALIS and CUTANEUS represent a new medical product category supporting cost-efficient, affordable,optimised care for amputees and diabetics. SAPHENUS has a strong network in medical research as well as in healthinsurances and in distribution partners. The SME-Instrument phase 1 business plan shall now be further implemented. Thephase 2 workplan foresees a duration of 24 months and requests 1,8 mio of EC funding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Targeted Herpesvirus-derived Oncolytic Vectors for Liver cancer European Network'.

assistant: **Innovation**

The overall objective of THOVLEN is to develop safe and efficient herpes simplex virus type 1 (HSV-1)-derived oncolytic vectors, designed to strictly target and eradicate human hepatocellular carcinomas (HCC), the most common liver cancer of adults. HSV-1 is certainly one of the most promising viral platforms for the development of improved oncolytic vectors, as anticipated by the unique biological properties of this virus and confirmed by the encouraging results coming from clinical trials in gliomas. However, the first generations of oncolytic HSV-1 vectors have also shown limitations regarding efficacy and safety. New generations of innovative HSV-1 vectors with improved potency and safety are required before the oncolytic strategy using HSV-1 becom es a standard therapeutic reality against cancer, and this is the goal of THOVLEN. One of the most important innovative contributions of our project concerns the overall approach towards the improvement of HSV-1-based oncolytic viruses. Instead of focusi ng on the development of vectors carrying deletions in particular virus genes, we will engineer competent, but replication-restricted, HSV-1 vectors, strictly targeted to HCC. These vectors will combine multiple HCC-targeting approaches, both at the leve l of entry and at the level of gene expression and replication, and will be able to multiply and spread only in HCC, while displaying no virulence in normal healthy tissues. Additionally, an important innovation is related to the ability of the HSV-1 vec tors to permit a sophisticated and flexible combined approach against HCC. That is, in addition to optimizing the oncolytic properties of HSV-1 vectors, THOVLEN will exploit the very large transgenic capability of HSV-1 to generate vectors that will sim ultaneously displa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How Adaptive Neural Dynamics Weight and Integrate Auditory and Visual Information during Multimodal Language Processing' in the context of a Horizon Europe call.

assistant: **Objectives**

HANDWAVE will develop a novel framework for understanding the neurobiology of multimodal language, by uncovering the multi-timescale oscillatory mechanisms that enable the flexible integration and weighting of auditory signals, such as speech, and visual signals, such as visual speech and hand gestures. Understanding how the brain integrates and weights these signals is crucial for understanding how natural language is processed in the brain. This knowledge is vital for diagnosing and treating language-related disorders, and for developing effective diagnostic tools and rehabilitation strategies. Two key gaps remain unaddressed. First, historical models on the neurobiology of language have predominantly focused on unimodal speech signals, overlooking the inherently multimodal nature of language. Second, it is unknown how the complex temporal relations between auditory and visual signals allow them to be integrated into one coherent percept. HANDWAVE addresses these gaps by testing the central hypothesis that the brain’s flexible coordination of multi-timescale oscillations enables the integration and weighting of auditory and visual signals through (interactions between) phase modulations, power modulations, and functional connectivity. Work package (WP) 1 will uncover the oscillatory mechanisms underlying the integration of speech and visual signals, and whether and how this gives rise to emergent multimodal representations in the brain. WP2 will examine the oscillatory mechanisms underlying the flexible weighting of auditory and visual signals. WP3 will provide causal evidence for the role of oscillatory mechanisms in supporting integration and weighting. By uncovering the multi-timescale oscillatory mechanisms underlying these processes, HANDWAVE has the potential to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The INscribed city: urban structures and interaction in ROME' (IN-ROME) under Horizon Europe.

assistant: **Objectives**

Rome as the first-ever mega-city reaching c.1 million inhabitants in the early empire (1st cent. BCE), remains an enigma regarding the way it organised itself and maintained that size for over three centuries. Having long outgrown the 4th-cent. BCE city walls, the urbanistic structures that developed outside of these, and especially outside the later Aurelian Wall, have never been studied systematically and holistically. IN-ROME aims to fill this fundamental gap. It will describe for the first time how different parts of the population (ethnicities, status groups, genders) and their activities map onto the city’s surroundings via military stations, association seats, sanctuaries, production sites, mines, agriculture, retail, baths, guesthouses, tombs and villas. Translating topographical relations into social ones, it aims significantly to enhance our understanding of the city’s social fabric.Methodologically, IN-ROME breaks new ground by unlocking the enormous potential of inscriptions for our understanding of Rome’s urban development and social fabric through virtual re-contextualisation and statistical analysis. The authoritative Epigraphic Database Roma will be extended to include all Latin and Greek inscriptions with known or probable provenance (totalling c.50,000). They will be linked to Rome’s most sophisticated Digital Archaeological Cadastre, SITAR, via a newly created map layer of 17th-20th-cent. properties (the main historic reference to location). These new resources will allow the exploration of topographical patterns of activities on an unprecedented scale, revolutionising access to a vast pool of historic information and restoring Rome’s people back into their landscape.Outputs include six books and two international conferences with proceedings. The geo