RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Next Generation AI Researchers for Air Quality Excellence' (NextAIRE) targeting Horizon Europe.

assistant: **Abstract**

NextAIRE is focused on boosting the interoperability, expanding expertise and providing a more balanced geographical and cross-sectoral circulation of European R&I talents in the field of air quality monitoring, actively involving environmental scientists, experts in hardware and Internet of Things (IoT) and machine learning engineers. The project is centred around a cross-sectoral and cross-country approach, with a strong focus on Widening countries. The training methodology, including 40 planned secondments and numerous collaboration activities, such as buddy systems, workshops, hackathons and ongoing assessment, is expected to drive sensor development and environment-related public health findings. The project is made up of 16 partners forming a highly interdisciplinary consortium with numerous SME-sized hardware producers. From a scientific perspective, air quality monitoring through low-cost sensorics and artificial intelligence is at the project's core. However, NextAIRE will use these topics to provide R&I talents hands-on experiences to increase their research, entrepreneurial and other transferable skills, strengthening the R&I human capital base and improving the excellence of the research carried out in Widening countries and beyond.NextAIRE will also generate outcomes that will positively impact the employability and sustainable career prospects for European R&I talents in the field of air quality monitoring, in both the academic and non-academic sectors alike. Results such as the NextAIRE Competency framework, mathematical and AI models and an e-learning platform featuring training materials on topics such as AI, data science and air pollution research, will help to achieve this goal.


**Keywords:** artificial intelligence, machine learning, air pollution,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analysis of DNA repair mechanisms leading to etoposide-induced MLL rearrangemensts and therapy-related leukemia' (MLL-J316).

assistant: **Concept**

The objective of my project is to analyse the MLL gene (11q23) and other loci rearrangements induced by topoisomerase II (topoII) inhibitors in hematopoietic stem cells. It is known that prior exposure to topo II inhibitors (e.g. etoposide) can result in subsequent development of therapy-related leukemias with MLL translocations, which are fatal complications of effective cancer treatment. Also, in utero exposure to environmental topoII inhibitors can lead to MLL infants' leukemias. Etoposide causes DNA damage in form of double strand breaks in DNA (DSBs), activation of p53 and induce cell death. DSBs in DNA are at a high risk for producing chromosomal rearrangements if cells aberrantly repair DNA. However, the mechanisms by which the specific aberration occurs are unclear.To address these issues, I developed an in vitro hematopoietic CD34+ stem cell culture model of etoposide exposure and recovery (Libura et al, 2005) and analysed MLL rearrangements by inverse PCR (IPCR) and fluorescence in situ hybridisation (FISH). My results clearly demonstrated that sublethal exposure of CD34+ cells to etoposide results in numerous aberrations in MLL gene fragment flanking topo II cleavage hot spots. In this study I will extend the previous analysis on the entire 8.2kb MLL bcr locus as well as other loci, with particular focus on primitive stem cells. In addition, I will analyse the biological significance of in vitro aberrations and determine if my experimental results are analogous to in vivo exposure by examination of blood from cancer patients during chemotherapy.The results of my study might provide new ways for prevention of fatal MLL leukemia. Project matches perfectly the main priorities of 6 Framework Program by promoting transactional mobility for training purpose s, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and Promotion of measures for vulnerable road users with regard to Mobility Integrated with Safety taking into acount the INexperience of the different Groups' (PROMISING).

assistant: **Innovation**

The objective of the project is to show the potential for reduction in casualties of vulnerable road users like pedestrians, cyclists, motorised two wheelers and young drivers, by technical non restrictive-measures.These measures will be compared with other measures to enable policy makers to weigh measures against each other.Cost effective analysis will be used to compare technical non-restrictive measures with other measures.Restrictive refers to mobility and directness. So the aim is to promote mobility as well as safety. This is to realise a change in (local) policy where safety measures for pedestrians and two wheelers very often were taken at the expense of their mobility needs and efficiency. To judge the restrictiveness, criteria will be developed and the road user viewpoint will be taken on board.The aim is to present measures in an implementation framework, in a way that (local) policy makers can take steps for a structural approach to come forward to the different needs of vulnerable road users. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Delfzijl Joint Development of green Water Electrolysis at Large Scale'.

assistant: **Concept**

Djewels demonstrate the operational readiness of 20 MW electrolyser for the production of green fuels (green methanol) in real-life industrial and commercial conditions. It will bring the technology from TRL 7 to TRL 8 and lay the foundation for the next scale-up step, towards 100 MW on the same site.   Djewels will enable the development of next generation of pressurised alkaline electrolyser, by developing embarking more cost efficient, better performing, high current density electrodes, preparing the  serial manufacturing of the stack and scale-up of the balance of plant components . Economies of scale combines with the flexible and optimized operation of the electrolyser, applying advanced electricity procurement and arbitrage strategies will ensure a low cost of hydrogen for the end-user during the 3 years of operation. This project will demonstrate the conditions for a profitable business cases for green hydrogen production as an input for green (or low-carbon) methanol production towards  large-scale deployment in Europe before 2030.  Djewels will be located in Delfzijl industrial park, where AkzoNobel already produces hydrogen through a chlor-alkali process and where the (bio)methanol producer, BioMCN, is also located. Delfzijl industrial park has with a direct connection to the electricity transmission grid, and low distribution network charges within. Other hydrogen industry clients in Delfzijl create further conditions for scaling up green hydrogen production. Beyond Delfzijl, the park is connected via a dense gas networks to other large-scale chemical and (petro)chemical hydrogen clients in the Netherlands and Germany. These could allow Djewels to be a stepping stone towards the creation of a new hydrogen valley, in line with the ambitions of the FCH2-JU and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rethinking the landscape of host defences against emerging viruses' (ReThink).

assistant: **Innovation**

All recent viral pandemics originated following human adaptation of zoonotic viruses. Our front-line antiviral defences are a major barrier to these viruses. Specifically, our cells encode antiviral proteins -that can be species-specific-, and directly inhibit viral entry, replication, and spread, thus influencing the outcome of infection. Current dogma states that antiviral proteins induced by interferon signalling, named interferon stimulated genes (ISGs), are the most significant front-line of defence. However, as ISGs are induced upon recognition of an already replicating virus, I hypothesize that an array of proteins that are constitutively expressed act to contain the initial wave of viral infection before the more specific and potent ISGs are expressed, thus providing a critical first-line of defence that influences pathogenesis and interspecies transmission. Supporting this hypothesis, my recent genome-wide multi-OMICs investigation of dengue (DENV) and influenza virus (IAV) restriction revealed that 75% of the proteins that inhibited viral infection are non-ISGs. Integrative analysis of these proteins revealed enrichment in general cellular pathways, -many not previously linked to viral restriction-, with significant enrichment in homeostasis maintenance. Moreover, depletion of one single of these proteins resulted in 100% mortality in infected mice, confirming their role in pathogenesis. Using DENV as a model of emergent WHO-priority virus, I will now characterize how these proteins inhibit DENV and other related (west Nile and zika) and unrelated viruses (IAV) (Objective 1). I will investigate their impact on DENV pathogenesis using attenuated and virulent clinical isolates (Objective 2) and as barriers of interspecies transmission using ex vivo models (Objec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced Microwave Plasma Gasification of pig and cow manure for cost-effective biogas generation' (PLAGASMIC).

assistant: **Concept**

The livestock sector in Europe is facing a problem: The manure it generates cannot all be used as fertiliser because excessive amounts of manure to land can lead to surface and ground water contamination through the accumulation of minerals in the soil, as manure contains high amounts of nitrogen and phosphorus. The EU has legislated to place severe restrictions on the quantity of organic manure that can be applied to land (170 kg N/ha/year). Farmers are facing increasing costs to export manure off-farms the current level of spreadlands is inadequate to meet the limits. There is an urgent need for the livestock farming community to develop a method of removal and reuse of animal manure such that the economic and legislative burden on them may ease through the development of an environmentally-friendly technology. Current technologies require very high capital investment that is out of reach of most of the farming community. Our project involves the pyrolysis of manure using microwave induced plasma (MIP) technology allowing a rapid release of biogas.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Organizing FISA and EuradWaste Conference under the Romanian Presidency of EU Council' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of the FISRAD project is the organization of the international conference FISA-EuradWaste in 2019. The conference will bring together researchers and policymakers from various member states as well as a range of stakeholders from international organizations, research organizations, businesses, municipalities and civil society to encourage open debate around key energy and nuclear research and training issues. The program of the conference will consist of plenary sessions, parallel sessions, a young generation session, poster session, final-workshops, technical visits, conference dinner and cultural  side events.FISA-EuradWaste 2019 is planned to be co-organized by the European Commission under the auspices of the Romanian Presidency of the EU Council and to be held in Pitesti, in Romania, between 4 and 7 June 2019, as a high-level research policy conference on the outcomes and perspectives of the Nuclear Research and Training Activities.The FISRAD project will dedicate efforts and resources towards the following main objectives:- to develop, in collaboration with European Commission, scientific experts and conference expert sub-contractors services (e.g. ENS), a programme covering all outstanding results of the European research achieved under the H2020 Euratom with the participation of  the most renowned specialists and speakers; - to make the European nuclear community at large aware of the conference and attract a broad audience to the conference, using modern and efficient means, tools and services in communication; and- to ensure the smooth organization of the Conference in Romania, providing innovative solutions to create an optimum environment for a fruitful exchange of information, networking and a broad dissemination of the nuclear fission re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanocomposite and Nanostructured Polymeric Membranes for Gas and Vapour Separations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The main scope of the DoubleNanoMem project is the development of nanostructured membranes based on the most appropriate combination of nanofillers with well-defined size and porosity, dispersed in advanced high free volume polymers with inherent nanoporosity for application in specific gas and vapour separations. This approach is driven by the main requirement for successful replacement of traditional gas and vapour separation processes by membrane-based separations: a radical improvement of the permeability and selectivity compared to state-of-the-art commercially available membranes.The use of nanocomposite and nanostructured membrane materials is seen as one of the few approaches with the real potential to achieve this goal and in this respect several combinations of polymers and nanoparticles will be tested. Different types of nanoparticles will be used, which are all able or have the potential to create preferential channels for mass transport: both single wall and multi wall carbon nanotubes, zeolites, mesoporous silicas and cucurbituril derivatives. The idea is to create a scientific basis for the combination of advanced polymers with suitable nanoparticles, compatible with the corresponding polymers, leading to membranes with unique separation properties. The principle targets of the project are:- Development of membranes with tailored separation performance based on innovative materials- Experimental characterization and development of structure-performance relationships.- Modelling of transport phenomena and of the material’s structure to provide a better scientific understanding of gas and vapour transport phenomena and separation processes.- Applied research in a select number of consolidated and emerging areas of gas separation and pervaporation, such as C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Oxidative damage role in fas-based cytotoxicity exerted by cytotoxic t-lymphocytes o target cells. Implication of mitochondria' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Fas is a member of the TNF receptor family of proteins, that, when cross-linked by mAbs or its physiological ligand (FasL), induces apoptosis. Fas-mediated apoptosis is of physiological relevance in the regulation and function of the immune system. A biochemical mechanism for Fas-induced apoptosis, as well as for the apoptosis process itself, is unknown . Oxidative damage has been implicated in some forms of TNFmediated cytotoxicity. Mitochondrial respiration is the cellular process from which free radical could be more easily generated, and it is directly implicated in TNF-induced cell death of L929 cells. The implication of mitochondrial function in Fas-based cytotoxicity will be tested using mitochondrial DNA-depleted U937 and Jurkat cells, as both the promonocytic U937 and the T cell line Jurkat are sensitive to Fas-induced cytotoxicity. Fas-based cytotoxicity will be tested using effector T cells, that express the functional FasL on their surface upon activation, especially CD8+ CTL clones.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'FLY HIGHER - Shaping the new evolving generation of aeronautic professionals'.

assistant: **Objectives**

The aeronautic industry is the key driver of European competitiveness, playing a fundamental role in facilitating economic growth and social inclusion, providing revenues to otherwise isolated regions and helping people to enlarge their horizons. However, the unprecedented economic crisis has posed several relevant challenges that affect European competitiveness, performance and sustainability. Europe is also assisting a main demographic development characterised by an aging population and also declining of younger age groups. In this context, shortage of qualified personnel may affect the aeronautic sector in the future, unless there is a joint effort to attract young Europeans to future careers in the field of Aeronautics. The main aim of the FLY HIGHER project is to attract, motivate and encourage young Europeans to embrace future careers in the field of Aeronautics by raising awareness of young people about future career paths in aeronautics .The project will promote a wide range of well-balanced activities, the “FLY HIGHER MISSION – Pathway to Success”, intent to reach three different target groups children and youth; teachers and educators; counsellors and Career Advisors. A wide programme of “EDUTAINMENT” activities includes hands-on experiments; games and simulations, visits, workshops, competitions, science cafes, training for teachers and career advisers, speed-dating, organisation of the “AIR DAY”, STEM tutorial and career kits will promote the establishment of a closer dialogue and allowing a direct contact on a friendly, informal and fun environment between children and youth, parents, school community, universities, industry and several aeronautic key stakeholders. With the project at least 20,000 participants are expected to be involved, more than 500,000
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Trapping of atoms on a super-conducting atom chip'.

assistant: **Innovation**

Atom chips have led over the last years to important progress in the field of cold atoms and interesting potential applications. Such experiments aim at trapping atoms in the magnetic field created by micron-sized wires. The latter are easily engineered by standard microelectronic techniques.The possibility to create any kind of magnetic potential allows for precise manipulation of the atomic sample, particularly interesting if the atoms are in a condensed phase and hence exhibit a collective quantum behaviour. Moreover atom chips offer a natural playground to bring atoms close to conventional micro- or optoelectronics systems and use their coupling to the latter.We are building an atom chip with superconducting Niobium wires as opposed to earlier experiments using normal metals. The lithography of superconducting circuits is a domain of expertise of the applicant. Our cryogenic system will bring important information about the dynamics of the trapping, in which current fluctuations play a crucial role and can become a limiting factor.Current noise properties are completely different for superconductors and could improve earlier performances of normal metals. As an example we want to trap the atoms in a permanent superconducting current without external power supply. More generally, the trapped cloud geometry will reflect the magnetic fields created by the superconducting wires.We want to use it to observe the remarkable properties of the superconducting phase such as the current distribution in the wire or the presence of vortices in the material. Our final goal is to excite the atomic sample towards Rydberg states where atom-atom dipolar coupling plays an important role, possibly relevant for quantum information processing.This program will develop superconducting det