RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Uptake and Exchange Mechanisms of Toxic Metals by Fungal Pigments : a Clue for a Better Understanding of the Accumulation Processes by Mushrooms ?' (2002-2006).

assistant: **Innovation**

After preliminary results obtained for the cap pigment of bay boletus, norbadione A, bandits ability to bind two caesium captions with a positively cooperative mechanism, the postdoctoral research project will start by the study of the exchange process between K+,the natural action bound to norbadione A, with Cs+. A very original combination ofmicrocalorimetry and electro spray mass spectrometry will be used to monitor and quantify this unusual alkali captions exchange. 13C and 133Cs NMR will provide further structural information on the K+ and Cs+ norbadione complexes in solution respectively. The accumulation of divalent heavy metals (Ni(II), Cod(II), Hg(II) and Pb(II)) in mushrooms has been often reported. Therefore the speciation of the corresponding complexes with norbadione A will be thoroughly examined using spectrophotometricand mass spectrometric methods in combination with classical potentiometer. Besidedimeric palinode-type pigments, monomer analogues are also present, sometimes enlarge amounts, in common edible mushrooms. Therefore, four of these catechu- orpyrogallol-type compounds will be studied. The strong binding properties of these moieties suggest the possible participation of Fe(III) or A1(III), transferred from the soils, in order to gather these monomer derivatives and to mimic" norbadione A withpulvinone-type coordination sites available to chelae monovalent or divalent deleterious metals. The self-assembly mechanism of these polynuclear supramolecular edifices will be studied using a combination of analytical methods and kinetic techniques. This multidisciplinary research project is addressing challenging issues in terms of environmental problems and food quality and safety."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding food-gut-brain mechanisms across the lifespan in the regulation of hunger and satiety for health', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Full4Health is a multidisciplinary European collaboration of internationally renowned laboratories investigating the mechanisms of hunger, satiety and feeding behaviour, effects of dietary components and food structure on these processes, and their possible exploitation in addressing obesity, chronic disease and under-nutrition. The proposal integrates investigation of both human volunteers (dietary/exercise intervention studies and administration of encapsulated nutrients) and laboratory animals with emphasis on neuronal, hormonal, molecular, physiological and psychological responses to food at different stages of the life course. We will apply imaging and other cutting edge technologies in both humans and rodents to answer critical research questions at different levels of the food-gut-brain axis. In human volunteers, responses to diet will be investigated from childhood through to the elderly, whereas wide-ranging cutting-edge rodent studies will investigate related issues such as early developmental programming the food-gut-brain axis, multiple feedback signalling interactions, and inflammation-induced anorexia. The project will examine the interaction of food and dietary components with the gastrointestinal tract, and will characterise the role of gut endocrine secretions, the vagus nerve, and hindbrain, hypothalamic and forebrain structures in signalling and integration of hunger and satiety. Physiological and psychological responses to food may change as we develop and age, with impact on food choices and preferences. This is a critical issue in the battle against food intake-related chronic disease, most commonly driven by over-consumption, but also in consideration of relative under-nutrition in the elderly and clinically compromised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Make-ready of microwave technic applied to restoration of wooden objects and archives' (MITAR) under Fourth Framework.

assistant: **Objectives**

Due to environmental concerns, the research is being focused on the development of no pollutant technologies in new applications. This has arisen the idea of make-ready a well known technology, the microwaves, as remedial treatment of wooden objects (object d'art, furniture, paintings) and archives attacked by xylophagous agents. The aim of this project is to develop a treatment that eradicates the destructive agents by microwaves: - quick and effective - cheap - no-contaminant taking into account that this technology does not produce the material degradation on polychromes, varnish, paper, and so on.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Marine and Maritime Research, Innovation, Technology Centre of Excellence', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The MARITEC-X consortium aims to create a Marine and Maritime Research Innovation and Technology Centre of Excellence based in Cyprus to act as an enabler of scientific and business excellence in Marine and Maritime issues in the Eastern and broader South-eastern Mediterranean. The Centre will be aligned to the overall Smart Specialization Strategy for Cyprus (S3CY) and the European priorities on specific pillars with competitive advantages to the Cypriot economy. Focusing on key priority sectors identified within the Smart Specialization Strategy for Cyprus such as energy, tourism, transport and shipping, MARITEC-X Centre of Excellence will seek partnering relationships with well-known European institutions that will assist to the transfer of knowledge, co-develop sustainability and research programs, handover best practices and consult towards the creation of a critical mass of infrastructure and human capital in the region.


**Keywords:** Marine, Maritime, business plan, Cyprus, East Mediterranean, scientific excellence, Larnaka, Limassol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of european pilot network of stations for observing cloud profiles', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

IPCC 95 states that the most urgent scientific problem requiring attention to determine the rate and magnitude of climate change and sea level rise are the factors controlling the Distribution of clouds and their radiative characteristics. Clouds are now represented in Models by prognostic variables and there is an urgent need for validation. This proposal is to optimise a network of three pre-existing sites for observing cloud profiles with radar and lidar and retrieving the variables such as cloud water and particle size for comparison with the Prognostic variables held in operational models, leading to the definition of instruments and algorithms for GCOS cloud remote sensing stations to monitor cloud properties over Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'UHI-NMS Multimedia Learning Initiative'.

assistant: **Objectives**

The University of the Highlands and Islands Project (UHI), the National Museums of Scotland (NMS) and The Multimedia Team (TMT) have formed a partnership to develop innovative multimedia learning content in the field of arts, culture and heritage. The partnership plans to trial iteratively the introduction of, and end-users' reaction to, leading-edge pedagogical approaches and appropriate technical solutions for the remote use of that content.Objectives:1. to trial content in real learning environments (UHI network includes more than 50 sites in the Highlands & Islands)2. to deploy multimedia technologies to extend and enrich access to cultural and curitage repositories3. to adopt a leadership role in the application of new pedagogical approaches to improving accessibility and take-up4. to exploit new digital resources and the expertise of the partnership to create content higher in quality and appeal than has previously been possible5. to add a new thematic dimension to existing provision on community learning networks and so enhance their sustainabilityWork description:Objectives will be achieved through the integration of UHI's learning network and course structure with the NMS's digital collections. Technical fulfilment will be through the multimedia design and programming of TMT.The distributed locus for trials will be UHI's Learning Environments and Research Network (LEARN): two R&D units dedicated to Learning Environments and Technology, and Reflective Practice in Learning and Teaching. Trials will be undertaken on three work packages, each one a learning unit derived in theme and structure from a UHI programme module. Content will be designed to have application in formal and informal learning environments; therefore, trials will address a range of end-user grou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GEOarchaeology of DAily Practices: extracting bronze age lifeways from the domestic stratigraphic record' (GEODAP).

assistant: **Concept**

What was daily life like in the European Bronze Age? In contrast to large-scale narratives based on artefacts, often prestige items from funerary contexts, this project focuses on the practices of daily domestic life, recorded in the sediments upon which it took place. These constitute the domestic stratigraphic record. This project, therefore, shifts the scale and the object of archaeological investigation, and aims at bringing interdisciplinary scientific analyses into dialogue with anthropological understandings of lifeways and households. Its main objective is the formulation of an innovative narrative of the Bronze Age addressing social, economic, and environmental aspects of a culturally interconnected region of Europe. The daily practices and life histories of bronze age people will be the pixels of this new picture that challenges previous depersonalized narratives relying on material culture. The region between the Carpatho-Danubian basin, the Balkans, and northern Italy was selected due to its important cultural interactions during the Bronze Age. Ten key archaeological sites in six European countries constitute the project’s database. Its innovative interdisciplinary approach integrates geoarchaeology (micro-stratigraphic analysis), organic chemistry (biomarkers) and archaeo-botany (phytoliths, seeds, fruits, and charcoal) to reconstruct with unprecedented accuracy the daily practices from domestic stratigraphy. This information will be compared with the story told by material culture and integrated with local paleo-environmental records. The project, in fact, challenges also previous reconstructions that called in environmental mega-events (volcanic eruptions, glacial advances, aridity events) to aprioristically explain broad cultural phenomena of the Bronze
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Advanced optical waveguide analysis of proteins and cells' (OPTICELL), addressing dissemination and exploitation.

assistant: **Impact**

A new type of optical waveguide will be developed in order to enable individual living eucaryotic cells to be monitored in situ with extremely high resolution. Their response to drugs, toxins and other xenobiotics as well as viruses can thereby be comprehensively monitored. Bacterial-eucaryote interactions can also be monitored. The novel waveguide will form the core of a new type of universal nanodevice for clinical diagnostics and toxicity testing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of the transcriptional regulation of the antioxidant network in bundle sheath cells of Arabidopsis using a novel immunocapture technique for bundle sheath specific polysomes' (ANTIOXARAB).

assistant: **Concept**

The objective of this proposal is to investigate the transcriptional regulation of genes encoding the antioxidant network and their cognate transcriptional factors (TFs) in bundle sheath cells (BSC) of the Arabidopsis leaf.Based on previous data concerning the BSC-specific stress-responsive expression of the ascorbate peroxidase 2 gene (APX2), it is postulated that the expression of the antioxidant defence gene network and its controlling TFs in BSC of the leaf subject to excess light stress, wounding or pathogen infection is constituted differently from that in cells of the leaf lamina.Therefore, it is postulated that a regulatory network model, and by implication its description of cellular ROS metabolism, will have different properties to those derived for the whole leaf. I propose to establish a novel technique based on epitope-tagging of ribosomes only in a particular cell type and then to purify RNA specific to BSC and lamina cells separately from selectively immunoprecipitated polyribosomes. Next, the expression of antioxidant genes and TF genes known to influence their function will be examined by qRT-PCR.Finally, computational models will be developed to determine the likely impact of the stresses on antioxidant and ROS metabolism in these cells compared with that from lamina tissue. These results will contribute to the development of sustainable agricultural systems since the knowledge of antioxidant networks in specific tissues will allow to determinate the most favourable conditions for the most efficient utilisation of environmental resources and therefore reduce chemical pesticides in crop production.It will also contribute to other fields, even biomedical, since the technology of epitope-tagging of ribosomes to purify RNA from a specific cell type potenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Natural history of Mild Cognitive Impairment and Alzheimer’s Disease: factors influencing early detection, clinical course, and prognosis'.

assistant: **Concept**

Background: There has been great interest in identifying persons at high risk of developing Alzheimer disease (AD) and dementia, as they should constitute a target group for possible prevention or early treatment of dementia in the future. Mild Cognitive Impairment (MCI) is a transitional zone between normal cognitive function and clinical AD.  The MCI syndrome is characterized by subjective memory problems and memory deficits. Persons with MCI have an increased risk of developing dementia but some are stable or even recover, while others have an increased risk of death. As not all subjects with MCI progress to dementia, there is a need to examine factors that determine which MCI subjects will develop dementia.  Aims/implementation: The main aims include to: 1) identify predictors of AD in the early, prediagnostic phase of the disease; 2) evaluate prognostic factors in patients with MCI;  3) explore the natural history of AD and other dementias and; 4) assess the occurrence of behavioral and psychological symptoms in dementia. The two-year Fellowship will be conducted at the Santa Lucia Foundation, Rome, and the Italian National Research Council, Institute of Biomedical Technologies, Milan. Three Italian, multi-center, clinical cohort studies on patients with AD and MCI will be investigated: 1) Behavioral and Psychological Symptoms of Dementia (BPSD) multi-center Italian study, including 1015 patients with AD; 2) The Italian Dementia Study, a multi-center clinical study of 1550 patients with MCI, AD and other dementias and; 3) The Italian Network on AD, MCI study, including 270 subjects with MCI, who were referred to 21 neurological centers around Italy in 2000-1. Relevance: The current project might have considerable implications n public health and understanding the n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The molecular drivers of deep-sea adaptation in brittle stars', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The deep-sea covers about two-thirds of the world’s ocean bottoms; yet, it is one of the least known environments of the planet. Given its harsh environmental conditions, life in high depths requires several specific metabolic adaptations. Surprisingly, little is known about the molecular mechanisms underlying adaptation to such environments. Which and how many genes are involved in adaptation? What is the extent of convergent evolution across distantly related taxa? Brittle stars (Ophiuroidea) are a useful group of marine invertebrates to study for this purpose, as they are abundant in the deep-sea and they colonized this environment several times independently, thus highlighting their strong adaptive abilities. Here, I intend to investigate deep-sea adaptation using a comparative genomics approach and state of the art analytic tools. I will first use an existing dataset to examine adaptive protein evolution (genealogical discordance and positive selection), by comparing 400 genes across 800 species of shallow- and deep-water brittle stars spanning the entire Ophiuroidea diversity. I will then focus on five cryptic species complexes representative of the major bathymetric transitions, by analyzing >10,000 genes generated from exon-capture and focusing on specific candidate genes. Finally, I will investigate allele frequency shifts among depths for two species displaying a wide bathymetric range using a genome scan approach (generation of two high-quality reference genomes; whole genome resequencing for 120 individuals). With these three approaches spanning a wide phylogenetic range, I intend to decipher the molecular mechanisms underlying deep-sea adaptation. This is of high importance because deciphering mechanisms of stress-driven adaptation may provide hints on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Precise electrochemical machining' (PEM).

assistant: **Innovation**

Development of hard-moulding tools for Micro embossing/ Microinjection moulding of copolymers consisting of small complex micro cavities of a surface roughness < 100 nm and geometrical tolerances < 1 micrometer and producing high-volume all-in-plastic micro fluidics for various processes.