RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanobodies blocking immunosuppressive unexplored proteins from the tumor endothelium to promote anti-tumor immune response' under Horizon Europe.

assistant: **Concept**

In non-small cell lung cancer (NSCLC), approximately 80% of patients have a poor response or develop resistance to current immunotherapies (IT), highlighting a critical need for more effective treatments. To date, most ITs focus on targeting cancer or immune cells, often overlooking endothelial cells (ECs), the body's largest organ. In the running ERC Adv Grant project MystIMEC (#101055155), we demonstrated the immunosuppressive nature of tumor ECs and their pathobiological role in tumor progression. With up to 90% of new drug candidates failing in clinical trials, often due to suboptimal target selection, the host lab has taken a fundamentally different approach to discovering novel therapeutic targets. Leveraging cutting-edge in-house developed AI and gene prioritization tools together with EC-selective lipid nanoparticle-based genetic silencing in a mouse lung tumor model, we discovered and validated 26 previously unexplored immunosuppressive genes (with poor functional annotation, ca 1/3 of human coding genome) as candidate therapeutic targets specific to ECs: silencing these genes promotes anti-tumor immune responses and reduces tumor growth. This ERC-PoC proposal builds further on these findings, aiming to develop nanobody (Nb) therapeutics for three promising targets with the greatest therapeutic efficacy. These targets are either secreted or membrane-exposed and therefore amenable to Nb-based inhibition, a treatment modality successfully used in the clinic. The results will provide the first Proof-of-Concept that our visionary approach to discover and validate unexplored immunosuppressive genes is an efficient, innovative, game-changing strategy. After generating Nbs, we will screen for the top two candidates with the strongest neutralizing effects in vitro (amo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Method for Integrated All-Optical Biological Analysis at Scale'.

assistant: **Objectives**

The advent of light-emitting sensors and light-driven actuators has profoundly transformed the fields of biology and medical science over the past three decades.  These innovations enable the manipulation and monitoring of various physiological processes using light with remarkable precision in both time and space. Applications include the study of signaling and cell trafficking in healthy and malignant tissues, the unraveling of causal relationships within neural networks or the assessing the effects of pharmaceutical compounds.  To fully harness the potential of these so-called optogenetic technologies, there is a pressing need to create integrated optical systems offering both 3D imaging and precise light-targeting of specific regions at scale. Within the framework of the ERC, we have successfully engineered a unique system designed for the optogenetic probing of small vertebrate brains (zebrafish larvae) at cellular resolution. Our proposal expands upon this earlier achievement, by evolving it into a versatile all-optical platform tailored for biologists and biomedical laboratories. This platform will seamlessly integrate cutting-edge optical systems with automated data analysis through artificial intelligence (AI) techniques. Anticipating a vast array of applications, we envision that this platform will prove invaluable e.g. in the realms of neuroscience, developmental biology, and cancer research. Its multifaceted capabilities will empower researchers to unlock new insights and accelerate advancements in these critical scientific domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'canceR agnOstic immUnoTherapy predIctioN blood-tEst' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer is the second leading cause of death worldwide, accounting for 10M deaths in 2020. Although 7 Immune Checkpoint Inhibitors (ICI) are approved for different cancer indications and have represented a true breakthrough, only 10-50% of advanced cancer patients respond to the treatment. This unpredictability of results, together with 15-60% severe toxicity rates and high prices are restricting the impact potential of ICIs. Predicting ICI response is critical for fully realizing their potential in treating early-stage tumours and enhancing ICI treatment regimens.PamGenes IOpener is a ground-breaking in vitro diagnostics testing platform for ICI response prediction. Made possible by PamGenes proprietary microarray-based kinase activity profiling of host immune cells, it can predict a patients response before ICI therapy is started from a simple blood draw. The IOpener aims to revolutionize the precision-medicine sector, enabling the widespread use of ICIs at any cancer stage.


**Keywords:** In vitro diagnostic testing platform,Immunotherapy response prediction tool,Kinase activity profiling,Multi-omics,Immune checkpoint inhibitors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Kinetic Inductance Detectors – a New Imaging Technology for Observations In and From Space' (SPACEKIDS), addressing dissemination and exploitation.

assistant: **Impact**

We propose to develop advanced imaging arrays of kinetic inductance detectors (KIDs) for space-based observations at mm-far-infrared (mm-FIR) wavelengths. This development addresses the FP7 topic SPA.2012.2.2-01: Key technologies enabling observations in and from space.Future space science and earth observation missions are limited by the availability of imaging detector array technology for the mm-FIR wavelength range (3 mm to 30 μm). For the wavelength range 28-45 μm there is currently no high performance technology with space heritage. For longer wavelengths, 45-2000 μm there is European expertise in a range of detector technologies, including photoconductors, bolometers, and transition edge superconducting (TES) detectors. However these technologies present significant fabrication difficulties, and lead to a high degree of complexity of system integration and readout electronics for the large format arrays demanded by the next generation of astronomical and Earth observing missions such as FIRI, SPICA, CoRE and Millimetron.The KID is a relatively new and potentially game-changing superconducting detector technology which can provide photon noise limited sensitivity over the entire mm-FIR wavelength range. KIDs are extremely simple both to fabricate and to integrate. Crucially, they can be read out with a high multiplexing ratio which dramatically reduces the complexity of cryogenic interconnections, cabling and electronics enabling larger format arrays than ever before. The reduction in complexity at the cryogenic level in contrast with other ultra-sensitive cryogenic detectors is extremely attractive and enables a dramatic increase in mapping speed for broad band imaging as well as novel applications in spectropolarimetry and hyperspectral imaging.This proposal dra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development and in vivo testing of bioartificial liver support systems for treatmnet of acute hepatic failure'.

assistant: **Concept**

To obtain primary porcine hepatocyte cultures and determine rate equations for oxygen consumption and other metabolic reactions in various culture media and in liver failure serum.To perform hydrodynamic optimisation and obtain macroscopic transfer models of specific bioreactors containing immobilised primary porcine hepatocytes. To evaluate bioreactor function in vivo model of liver failure.Engineering design techniques and mathematical analysis in conjunction with relevant cell biology and clinical experience will be employed to develop optimised hepatocyte bioreactors for treatment of fulminant hepatic failure (FHF). Primary porcine hepatocytes will be obtained and evaluated in static cultures using different culture media, normal blood plasma and FHF plasma. Cell viability will be assessed by lactate dehydrogenase release and function by cytochrome P450 content, activities of P450 isoenzymes, urea synthesis and changes in reduced glutathione content. Rate equations for several liver dependent metabolic functions will be obtained in a smallscale flow reactor seeded with porcine hepatocytes. The influence of metabolite concentrations and physical operatic;, parameters ( e.g. shear rate. cell density. pH) will be studied. A novel oxystat apparatus will be used to determine cellular oxygen consumption during the critical phase of cell attachment to selected substrata as well as in the post-attachment phase of operation. These fundamental properties will enable the development of macroscopic mass transfer models of two existing bioreactor designs. Both designs utilise fibre technology to provide integral oxygenation. Fluid dynamic optimisation of these devices will he carried out and scaling rules established for bioreactor scale-up. Long term in bitro testing of the bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cementochronology Unravels Seasonality in Prehistory' to be submitted under Horizon 2020.

assistant: **Abstract**

Archaeological sites are by and large palimpsests of coarse-grained chronological resolution, with many episodes of (re-)occupation where often undifferentiated blocks of time are used as units for temporal reckoning. The methodological advances provided by cementochronological approaches can provide powerful means of temporalising and refining our understanding of annual scheduling of site occupation. Cementochronology examines alternating incremental translucent and opaque bands that are laid down throughout life in tooth cementum as physiological responses to seasonal rhythms. Counting pairs of bands on thin sections under polarized transmitted light provides accurate age estimates. The outermost band represents the season-at-death, which is used to infer  seasonality of site occupation. This method is particularly relevant for prehistoric periods when seasonal scheduling of lifeways was of paramount importance. The CUSP project uses the most recent methodological breakthroughs in the study of Tooth Cementum Annulation (TCA) to establish (1) a robust protocol for the study of TCA in red deer, which is often found at prehistoric sites as hunted game; and (2) infer seasonality of occupation of archaeological sites in the chosen case study by determining season-at-death in both red deer and humans. Age-at-death estimates will be made for the analyzed samples too, enabling the applicant to build mortality profiles important for estimates of past human population demography and red deer hunting strategies. The case study are Mesolithic sites in the Danube Gorges region of the Balkans where CUSP will test the hypothesis about possible sedentary occupation of this region in the Mesolithic. The applicant has worked extensively on the archaeological sequences in this region a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing replicable and cost effective Nearly Zero-Energy' building solutions for small builders in Europe', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The building sector is responsible for the majority of the energy consumption in the world. It is also a key challenge for the20-20-20 strategy of the EU.Sustainable housing starts with 'near zero-energy' buildings, i.e. homes that are so well insulated that it becomes easy toproduce more renewable energy on site than what is consumed.Today, house construction in Europe is mainly performed by craftsmen who are small local builders and who work withtraditional technics and who are not keen to invest on research and development of Modern Methods of Construction(MMC). As a consequence, it remains very difficult for consumers and investors to buy 'plus energy' houses in Europe (costsand lack of offer due to lack of know-how).The objective of the project is to provide to local builders the products and the tools so that they can offer to their customers'nearly zero-energy' buildings with guaranteed performance and cost controls.To do so, ECOXIA has developed the concept of ""Smart Envelope"". Built in the ideal conditions of the factory, the envelopeis installed in a 'Plug & Play' way on site in one day. It includes both energy performance and the components to make itsmart.ECOXIA developed a prototype in 2012 to check the performance of its building envelope. Installed in Yerres, France, itproved the interest of the concept from a mechanical, thermal, comfort and cost standpoints. The recorded consumptionproves that the prototype is a 'plus energy' building with the production of only 20 sqm of photovoltaic solar panels.To be able to commercialise the right solution and help Europe to develop a new industry, ECOXIA needs to go further intoits feasibility study by addressing the following questions:- which is the best level of prefabrication?- how can we improve the price of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sustainable, Wireless, Autonomous Nanocellulose-based Quantitative DoA Biosensing Platform' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Paper-based printed electronics are new recyclable electronic devices with technical, economic and environmental advantages. Additionally, nanocellulose (NC) based printed electronics, produced mainly from wood pulp, offer better printability and performance than paper. Therefore, the integration of NC-based printed electronics and biosensors is a promising source of innovation in the biomedical industry. In GREENSENSE we propose the development of a sustainable NC-based biosensing platform for Drug-of-Abuse (DoA) analysis, that integrates high-added value printed electronic components (a new biosensor, an NFC communication system, an energy storage system and a display) with a silicon microchip to provide it with multi sensor data processing, autonomy and wireless communication and that is easy for the user to read.  The main goal of the project will be the use of NC as: substrate for the printed electronics, lamination film for the encapsulation of the final device and as active component in the formulation of functional inks (conductive, electrochemical, electrolyte and dielectric). In all cases the NC surface will be functionalized to be printable, with good barrier properties and compatible with the functional inks (bioactive, conductive, dielectric, electrochemical, electrochromic and electrolyte). Pilot lines and high throughput, high precision and cost-effective S2S screen-printing and ink-jet printing techniques will be used to produce materials and components at large-scale. Two types of DoA biosensing platforms to eradicate the consume of drugs among the society will be developed: a strip-based platform (2nd generation) that will be connected to a Smartphone and a strip+reader-based platform (3rd generation) that will also include a display. The final flexibl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Linking vector, virus and immunity to the evolving fitness of dengue virus' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Across pathogens, it remains unclear why some lineages persist while others die out. Population immunity pressure coupled with relative abilities to infect and disseminate in hosts are likely to play a critical role. There are key data and methodological gaps that prevent us from identifying and quantifying drivers of pathogen fitness. We need robust measures of fitness and be able to apply these measures to sequences from the same ecological disease system over many years. We also need to understand how an individual's immunity responds, if at all, to ongoing exposures by continuously changing pathogens. Finally, we need appropriate methods that can integrate candidate drivers of fitness within the same analytical framework. Using dengue virus as a model system, I will use annual sequence data from Thailand collected from 1973 to today alongside long term measurements of immune responses in the same individuals over 25 years apart to answer the following questions:- How does individual immunity change over decadal time frames? I will re-recruit individuals who were infected with dengue virus during participation in cohort studies in the 1990s. I will measure their antibody response today to viruses that have circulated over the past 58 years, including the specific virus that infected them in the 1990s. I will compare their responses today to those in stored samples from the original cohort study. - What are the drivers of fitness? I will quantify the changing fitness of circulating dengue viruses from 1973 to today. I will then explore how changes in viral dissemination in mosquitoes, changes in kinetics in human cells and the build up of strain-specific population immunity interact to determine viral fitness. By studying the dynamic interplay between pathogen fitness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bridging the gap - research and experimental validation on the dst performance test method for solar domestic water heaters' (1994-1998) under Fourth Framework.

assistant: **Objectives**

European quality standards for Solar Domestic Hot Water (SDHW) systems are being prepared by the CEN Committee RC 312. The Dynamic system testing (DST) method is one of the methods chosen there to measure the energetic performances of these systems. An outdoor DST test on a SDHW system suffices to give predictions of the energetic performance for a whole year under various climates and circumstances.The project objectives are:- Comparison of the DST method to the 'CSTG' method, which is also used in the CEN, leading to correspondence factors which enable comparison of DST results with CSTG results.- Fine-tuning of the present description of the procedure to an expected reproducibility of 5 to 10% with predictions for different climates and hot water consumption.- Clear demarcation, definition and widening of the scope of the test method to allow for as many systems and conditions as possible.- Experimental validation of the DST method by means of intercomparison tests in a number of recognised laboratories throughout Europe.In the first year of the project, the project has booked progress almost according to schedule. Extensive calculations have been performed to localise and analyse weak spots of the DST methods. This work will expectedly result in recommendations to improve details of the test procedure. In order to broaden the scope of application of the DST method. Measurements in order to compare the CSTG method and the DST method will be discussed in the second meeting in December 1997. The actual experimental validation will start in 1998.