RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Immunological synapse derived ectosomes in T cell effector function'.

assistant: **Innovation**

The immunological synapse is a highly conserved scaffold for communication between immune cells built around cooperation of antigen and adhesion receptors. It often takes the form of a bull’s eye with a central cluster of antigen receptors surrounded by a ring of adhesion molecules. We have recently observed that antigen receptor coated extracellular microvesicles bud directly from the center of the immunological synapse- which we define as synaptic ectosomes. Synaptic ectosomes are transferred to the antigen- presenting cell and can generate signals after the T cell-APC synapse has dissolved. We aim to determine the composition of synaptic ectosomes, determine their fate in the antigen-presenting cell and identify approaches to manipulate their formation in vivo. The objectives will be to 1) isolate synaptic ectosomes from human T cells and determine their molecular composition; 2) determine the functional impact of synaptic ectosomes on the antigen presenting cell; and 3) use gene targeting to control the process in vivo to understand its role in T function of helper, cytotoxic and regulatory T cells. The technologies will include microscopy, proteomics, genomics, and in vivo models with constitutive and conditional gene targeting. This work will address fundamental gaps in our understanding of immune cell communication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multi-platform configuration management, process improvement experiment' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

TransAction is a database technology company founded in 1987. The products of TransAction are: (i) the relational database system TransBase and (ii) custom database application development on behalf of our customers. The primary product, named TransBase, is a relational database system available on a variety of different system platforms ranging from Apple Macintosh to main frame VMS. Users expect identical quality, performance and programming interfaces on all those platforms. One of the most important requirements is to assure quality in a multi-version, multi-platform environment. The importance of improving processes to ensure and increase quality in software development is not only recognised inside our company, but also expected by our customers who rely heavily on the quality of our software once it is released. Because the software is a basic part of their customer deliverables software quality of TransBase is very critical for our company and our customers.This PIE project has the following goals: Increase our software quality by improving the software development process. In our case, this means establishing programming conventions, improving source code control, and establishing effective multi-platform validation procedures. Reduce manpower costs for platform-specific overhead.THE EXPERIMENTEstablish design and programming conventions that are obligatory for each programmer and system designer. Try to eliminate platform-specific problems as early as possible.Improve configuration management. Replace or extend the current source code administration system by a more powerful system suited to handle multi-platform aspects and capable of handling code-related documentation and/or platform-specific test results.Improve the testability and comparability of the dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Scale up user-Centric and dAta driven soLutions for connEcted Urban Poles' to be submitted under Horizon 2020.

assistant: **Abstract**

In SCALE-UP 3 advanced urban nodes Antwerp, Madrid and Turku, team up around 1 main goal: develop data-driven and user centric strategies to accelerate the take-up of smart, clean and inclusive mobility, by means of well-connected and multi-usage urban nodes, to the level needed to meet EU climate and transport objectives. To reach the main goal, 5 strategic objectives are defined:- Improve multi-level and multi-stakeholder governance enabling seamless multimodal transport across urban nodes - Develop (inter)connected and multimodal nodes for passengers and freight as a backbone of a resilient mobility system, including network optimisations -Develop data driven mobility strategies and tools to stimulate seamless multimodal transport of passengers and freight and optimise network capacity across the wider urban area - Provide access to inclusive clean and safe mobility solutions - Change travel behaviour focussing on clean, active and healthy modes of transport The 5 objectives relate to fields of intervention in which the SCALE-UP urban areas excel and deliver valuable output by implementing 28 mobility measures scaled to the FUA and taking into account the TEN-T dimension. Furthermore a strong framework for thematic policy validation amongst SCALE-UP experts guarantees a meaningful cooperation between the 3 urban areas, internal capacity building and mutual exchange and learning.A 6th strategic objective (TAKE UP) defines how the project delivers evidence of the effectiveness of the different actions in relation to EU climate and transport targets, and how it accelerates the take-up of these solutions amongst and beyond SCALE-UP urban areas.The evaluation framework with proven EU record, provides evidence of the impact. Moreover the data driven approach pays special a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Bootstrap Program for Quantum Field Theory' (QFTinAdS), addressing dissemination and exploitation.

assistant: **Impact**

The importance of quantum field theory (QFT) in modern theoretical physics is hard to overstate. Nevertheless a proper mathematical framework to describe field theories is still lacking. This is felt most concretely in the world of scattering amplitudes, whose general properties are difficult to define from existing axioms. This hampers our ability to make progress in understanding strongly coupled field theories. In contrast, for conformal field theories (CFTs) there has been remarkable progress in recent years. The key ingredient here is the operator product expansion, which both significantly constrains correlation functions and whose associativity conditions can be analyzed numerically. These techniques are however only suitable for theories with a conformal symmetry, which normally only emerges at the endpoints of finely tuned RG flows.To advance the non-perturbative understanding of strongly coupled non-conformal QFTs new methods are needed. Among other things it is imperative to grasp the non-perturbative structure of scattering amplitudes. I propose to follow two interlinked paths based on recent results. The first approach concerns the flat-space limit of a QFT in a fixed hyperbolic background known as Anti de-Sitter (AdS) space. The second approach can be called the numerical S-matrix bootstrap. Both approaches hold great promise, but by pursuing them jointly I will be able to optimally leverage insights from one approach into the other.


**Keywords:** Quantum field theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DE-RISK the adoption of Local Flexibility Markets to unlock the safe and reliable mass deployment of Renewable Energy Systems' (DE-RISK).

assistant: **Innovation**

DE-RISK aims at supporting the market uptake of renewable energy systems by fostering the adoption of LFMs and unlocking up to 100GW of flexibility in 2030 which will allow a safe and reliable integration of RES in the grid. DE-RISK will achieve this ambitious objective by minimizing the investments and implementation risk through an innovative customer behavior change journey that will increase end users' trust and willingness to participate in the flexibility markets. DE-RISK integrates building, citizen and grids digital twins in its flexibility platform capable of reducing the gap between simulation and real implementation thus mitigating potential technical risks during deployment and operational phase. To maximize DE-RISK impact, innovative multi-sided business models will be developed ensuring multi-benefits, fairness and sustainability for all actors while disruptive financial schemes will be validated for democratizing the access to sustainable investments. Finally, a set of experts will develop regulatory recommendations to support a fair, clear and transparent adoption of LFMs.


**Keywords:** Local Flexibility Markets, Demand Response, Market uptake, Multi sided business models, User engagement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanofluidic devices for high-throughput single-molecule-fluorescence detection' to be submitted under Seventh Framework.

assistant: **Abstract**

Currently, the two prominent schemes for single-molecule fluorescence detection (SMFD), confocal microscopy and camera-based total-internal-reflection or wide-field microscopy, are ultimately limited in their ability to combine the detection of many molecules with obtaining data at sufficiently high time resolution, necessary for resolving fast dynamics with single-molecule fluorescence resonance energy transfer (smFRET). In particular, monitoring enzymatic reactions using smFRET is extremely challenging and remains to a large extent unexplored.Here, I propose a novel nanofluidic device to overcome these limitations by using nanochannels, which provide a well-defined flow path for afluorescent species through the excitation/detection focus of a  conventional wide-field microscope. Using an array of nanochannels offers several advantages: First, the geometrical confinement enables long observation times of non-immobilized molecules. Second, the residence time of molecules in the channels is easily controlled by the flow velocity set by the syringe pump. Third, faster flow rates together with using a CCD camera in ‘streaking mode’ enable a sub-millisecondtime resolution. Fourth, a high-throughput detection is achieved by using a parallel array of channels. Fifth, enzymatic reactions can be directly triggered by mixing necessary components on-the-fly using an additional inlet.The described device will pave the way for high-throughput single-molecule detection, which will greatly expand the possibilities for researchers to apply single-molecule methods in the area of Life Sciences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Building Data Rich Clinical Trials' (2014-2020).

assistant: **Concept**

Successful drug approvals on Precision Oncology (PO) using basket studies have uncovered new challenges. Research in small patient populations suffers from sustainability/ logistical issues. Platform trials are flexible solutions to test different drugs in different populations but encompass management issues that compromise flow and translational research. This is detrimental to patients/ researchers thus new technological/ methodological concepts must be urgently implemented. To overcome these limitations, Cancer Core Europe (CCE) has developed the Basket of Basket (BoB) study to provide personalized treatment to a larger number of patients by incorporating a multi-tiered molecular profiling platform, flexible modules targeting different molecular alterations and a data/ sample collection plan to enable translational research. The CCE-DART model, here proposed, is conceived to address other limitations of PO and platform trials identified by our multi-disciplinary team. With a new design, we aim to improve efficiencies and transform platform trials in data-rich translational research programs, by: (1) developing digital systems (information-technology solutions) facilitating data management and clinical-decision-making; (2) integrating accurate, dynamic imaging and molecular markers of tumor progression/ drug response; (3) using more efficient, adaptive clinical trial methodology; (4) increasing patient engagement. To achieve this, we will use harmonized data-sharing/ technological/ legal/ clinical infrastructure developed in CCE and the BoB trial that will be leveraged as a use case for testing the new model. The new concept will impact the design of new clinical trials consolidating a self-sustainable, data-rich, multi-endpoint global platform for clinical/ translat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Disability Rights Expanding Accessible Markets' (DREAM) targeting Seventh Framework.

assistant: **Abstract**

The purpose of the proposed ITN is to explore options for EU disability law and policy reform in light of the United Nations Convention on the Rights of Persons with Disabilities (2007).  In particular, it will focus on the core rights of the individual, on expanding markets for European ICT business by making it more accessible to consumers with disabilities and on the need to find ways to embed a positive dynamic of reform throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'INTEGRATING ARMENIA INTO ERA' (INARMERA).

assistant: **Concept**

Integration of the South Caucasus countries into ERA is one of the priorities of EU’s European Neighbourhood Policy. This is the objective of ERAWIDE initiative aimed at reinforcing the cooperation capacity of a prominent R&D centre in these countries by providing the possibilities to improve its research activities in the areas of thematic priorities of FP7. The government of the Republic of Armenia recommended as such a centre the Center of Medical Genetics and Primary Health Care (CMG) due to its high reputation, broad international contacts, participation in FP7, and the importance of the top-level research in Medical Genetics for general population.To reach this objective, the INARMERA project consortium consisting of CMG, the Institute of Cancer Biology of the Danish Cancer Society, and the European Centre for Knowledge and Technology Transfer (Belgium) will carry out research assessment of CMG, will organise training in FP7 for CMG scientists and their research training in Medical Genetics. For networking and dissemination purposes workshops and summer schools will be organised in Armenia while Armenian scientists will attend events in Europe. Meantime from the start of INARMERA four Pilot Trial Projects in Medical Genetics will be organised between CMG scientists and their colleagues in Europe, but also in Georgia, highlighting the regional aspect of INARMERA. The Pilot Trials will help Participants to identify bottlenecks of cooperation and propose improvements.The Strategy Experts Group will develop strategy of CMG aiming at establishment of CMG as a visible centre of Medical Genetics studies in Caucasus, and turning it into a reliable partner for European institutions in Framework Programmes. Project results and achievements will be analysed and recommendatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Boosting photosynthetic activity via nanoparticle addition for biogas upgrading coupled with pigments production' (NANOBOOSTER), addressing dissemination and exploitation.

assistant: **Impact**

The urgent need to reach EU independence from fossil fuel imports, decarbonization and circular economy encourages the development of sustainable technologies for the production of biofuels and high added-value products. Photobiorefineries are a promising platform to produce biofuels and high added-value products. However, the low algal biomass productivities typically limit their application. NANOBOOSTER will engineer a high-performance photobiorefinery based on the addition of nanoparticles (NPs) to boost Haematococcus pluvialis metabolism, resulting in a biomethane that meets the EN 16723 standard (CH4>95%, CO2<2%) along with enhanced astaxanthin productivities. NANOBOOSTER will address two key scientific challenges: the elucidation of the mechanisms of interaction between NPs and microalgae and the single-stage production of astaxanthin. Overcoming the first challenge will allow the synthesis of tailored NPs to boost H. pluvialis growth and astaxanthin content. Then, the optimal conditions of temperature, light, pH, NPs and NH4+ concentration will be determined at lab-scale. These conditions will be validated in an indoors single-stage continuous system using real centrate as a culture broth, which will be pretreated via selective NH3 membrane permeation to achieve optimal NH3 concentration for astaxanthin accumulation. The process will be optimized to reach an upgraded biomethane with CH4 >95% and CO2<2%, and astaxanthin contents of 10%. Finally, the process will be validated under outdoor conditions at demo scale to assess its techno-economic feasibility and draft a business roadmap. NANOBOOSTER will position photosynthetic biogas upgrading as a cost-effective process easy to implement in the biogas sector. The fellow, Dr. Vargas, will conduct this action at the I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Revolutionary Ultra-Fast System for Hot-stamping of light weight structural vehicle components with Artificial Intelligence quality control monitoring'.

assistant: **Innovation**

The automotive market is driven by many safety performance assessment programs. Less CO2 emissions and reduced production costs are the main priority for OEMs, to comply with regulations and to strengthen their advantage in an extremely competitive market. The cost-effective reduction of a vehicle’s structural components, known as Body-in-White (BIW), has been one of OEMs’ main targets. Such reduction is possible with lighter BIWs, made of Advanced High Strength Steels (>1,500MPa), using a process known as hot stamping. Components produced this way can be 20-30% lighter compared to cold stamping. Hot stamping components account for 11% of the total current value of European vehicles; the state of the art has limitations that prevent extending hot stamping to more vehicle components, e.g. components with complex geometries, very thin or locally tailored components. Our innovation, RUSH AI, is an ultra-fast system for hot stamping of light-weight components, quality-controlled by self-correcting, online AI. It reduces manufacture cycling time by over 70%, thanks to a novel hydraulic press solution and a “sweating die” made by additive manufacturing and inspired by human sweat. Its efficiency results in savings of 70-80% OPEX. We aim to upgrade RUSH AI from TRL6 to TRL9. By project’s end, 2020, the hot stamping TAM will be €11.8bn, 13% of the total BIW market (€91bn). In the first 10 years of commercialization, SAM is estimated to reach €1bn. We expect sales above €148m by 2030 and a market share of 15%.Users will be OEMs and their Tier-1 suppliers. RUSH AI can be implemented in old and new hot stamping lines. A joint venture company is considered by the 3 industrial partners to commercialize the process line, yet each keeps the separate rights of exploitation of individua