RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AstroChemical Origins', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project ACO (AstroChemical Origins) has two main objectives: 1) to unveil the early history of the Solar System, using the chemical composition of today forming Solar-like planetary systems and comparing it with that of the Solar System primitive bodies; 2) to train a new generation of researchers able to tackle this highly interdisciplinary problem, providing them with a wide-range of transferable skills, including the ability to communicate Science to a large audience.This will be obtained by setting up: (a) a coordinated network of PhD research projects which will be carried out by 17 ESRs under the supervision of members of the ACO Beneficiaries; (b) a structured secondment network, to expose ESRs to alternative research environments;(c) a significant exposure of ESRs to the non-academic sector, via PhD co-supervision, secondment, short visits and training from non-academic ACO Beneficiaries and Partners; (d) specific courses at the host institutions as well as network schools with specialized interdisciplinary and transferable skills courses; (e) international conferences open to the scientific community; (f) several activities to make ACO network and its science known to the general public.In order to achieve the ACO objectives, the proposed network is constituted by fourteen Beneficiaries, whose four from the non-academic sector, plus seven Partner Organisations, whose six from the non-academic sector.  Each Participating Organization will provide a complementary expertise indispensable to achieve of the ACO objectives: (i) instrumental, observational, theoretical, computational, modeling, and experimental to reach the scientific goal and, (ii) on informatics, scientific presentation and management, for completing the wide-transferable training.


**Keywords:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Services in Support for Business and Innovation in Croatia - Key Account Management', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This action will establish and provide the innovation support services addressing in general Croatian SMEs with significant innovation activities and in particular the beneficiaries of the SME instrument. This action will provide continuation of the SSBI-CRO-KAM-2 proposal which is currently implemented under the remit of H2020 In particular defining innovation support packages  for:• Key Account Management (KAM) of successful SME Instrument applicants to identify bottlenecks to creation of economic impact in companies benefiting from grants by Horizon 2020,• Enhancing client SME’s capacity to manage innovation processes increasing their efficiency and effectiveness.Project partners UniSt, STEPRI, TPV, Tera and HAMAG-BICRO will each individually provide number of service packages according to the analysis of regional needs (regional coverage, number and readiness of clients).Envisaged outcome of this action is to provide services to SMEs in 2017-2018, including all beneficiaries of support under the Horizon 2020 SME instrument.


**Keywords:** innovation, SME, H2020, SME Instrument
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms that underlie loss of antigen tolerance in HLA-associated autoimmune diseases' to be submitted under Seventh Framework.

assistant: **Abstract**

An estimated 3-7% of Europe's population (80% females) suffer from autoimmune diseases (AID) that affect the body's various organs. In healthy people, harmless proteins from self, bacterial flora or food do not elicit a destructive inflammatory response due to antigen tolerance. Central to antigen tolerance is the function of regulatory T cells, a population of lymphocytes key to the prevention of excessive inflammatory tissue damage by immune effector cells. Unfortunately, the mechanisms that safeguard a balanced interaction of HLA class II-restricted regulatory and effector CD4+ T cells are incompletely understood. This explains why the current treatment of AID remains inadequate. Towards the priority research areas for chronic inflammatory diseases identified in the Innovative Medicines Initiative's Research Agenda 2008, we suggest the following original approaches: 1.) Identification of the functional roles of HLA class II-restricted CD4+ T cells in the induction/prevention of AID using a HLA-DR*0405 transgenic mouse model of autoimmune pancreatitis (AIP); 2.) identification of humoral autoantigens that can aid in the diagnosis of AIP; 3.) enhancement of a novel mouse model of human celiac disease (CD) by introduction of the CD-associated HLA-DQ8 (class II) allele; and 4.) pre-clinical testing of oral enzyme therapy, currently the most promising alternative treatment approach to CD, comparing efficacy in the existing CD mouse model of a 2-enzyme-glutenase (prolyl endopeptidase and endoprotease B2) vs. an extract of germinating wheat enzymes. This project will lead to insight into pathomechanisms that underlie loss of antigen tolerance in HLA-associated AID, development of a diagnostic serum test for AIP, analysis of the HLA-dependency of CD-specific autoantibodies a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'THE NARRATIVE LYRIC: CONCEPTUAL BLENDING OF SPATIAL SCHEMATA WITH EMOTION IN POETRY AND BEYOND' (NARLYR), addressing dissemination and exploitation.

assistant: **Impact**

The Narrative Lyric (NARLYR) explores mainly Greek (ancient and modern), English, and Spanish poetry to understand how some basic emotions, such as love, anger, fear, or hate, are integrated with schematic narratives grounded on embodied cognition. This process gives rise to a wide range of products of the imagination, and to a great variety of meanings and forms, all conceiving basic emotional situations and relationships as small spatial events at the scale of a human body. The methodology combines conceptual blending, image schemata, and other analytic tools from cognitive science and linguistics, with more traditional approaches from semiotics, poetics, and classical rhetoric. The main methodological hypothesis is that Fauconnier and Turner’s Conceptual Blending Theory can be productively employed in a systematic contrastive study of the figurative language of emotions, both in poetry and in other usages. In order to model recurrent imaginative patterns, NARLYR proposes generic structures of conceptual integration that build abstract networks capable to analyze a wide variety of examples, ranging from poetic imagery to other artistic manifestations, rituals, religious symbols, or everyday communication. The results expected should challenge the extended conception of the lyric as a non-narrative expression of feelings. As a cognitive poetics enterprise, NARLYR also employs empirical methods to explain literary production and reception in relation with human cognition, and to extend the model from the literary study so that it can contribute to the understanding of emotion language, along with related aspects in communication and art. The fellow will collaborate with leading groups of cognitive scientists, linguists and literary scholars in the US and Spain, under th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Thrombolytic Nanobody Therapy for Dissolving All Types of Blood Clots' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

TargED Biopharmaceuticals B.V., a spin-off from UMC Utrecht, is developing TGD001, an innovative first-in-class drug designed to treat all types of blood clots associated with thrombosis, a leading global cause of death that currently has limited effective treatments. TGD001 has shown superior results in preclinical studies, demonstrating high precision, safety, and efficacy, and TargED has raised over €45 million to fund its clinical trials, moving toward market readiness.Unlike existing therapies, TGD001 has the ability to target both von Willebrand Factor (vWF) and fibrin, addressing the varied composition of blood clots. This dual-target mechanism enables TGD001 to effectively dissolve both macrovascular and microvascular clots, making it a ""one-drug-fits-all"" solution for thrombotic conditions. This comprehensive approach extends the treatment window, reduces bleeding risks, and makes it suitable for a wider range of patients compared to existing therapies.TGD001 has received Orphan Drug Designation from the European Medicines Agency for thrombotic thrombocytopenic purpura (TTP), granting 10 years of market exclusivity, regulatory support, and financial incentives, significantly accelerating its development for immune Thrombotic Thrombocytopenic Purpura (iTTP), a rare and severe form of TTP.Led by an experienced team, TargED is advancing TGD001 through clinical development, targeting iTTP and Acute Ischemic Stroke (AIS), indications on opposite ends of the clot composition spectrum, with global potential peak revenues of €421 million and €5.2 billion respectively. TargED’s core strategy is to advance TGD001 through to MAA/BLA submission independently. To further support the development, TargED plans a €25M Series B funding round to execute Phase 2a trials and a 1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Revolutionizing Spatial Biology with a cutting-edge Multi-Scale Imaging platform' under Horizon Europe.

assistant: **Concept**

The NanoSCAN project aims to transform tissue analysis with a novel 3D spatial biology platform that provides crucial insights into cellular and tissue functions. Spatial biology visualizes the interaction of molecules with their 3D environment, which is essential for cell and tissue screening. However, most spatial biology imaging technologies, based on wide-field microscopy, have limited spatial resolution and insufficient molecular profiling. A major obstacle to quantitative tissue imaging progress is the lack of a single instrument that can cover various complementary scales from tissue to molecule with high speed, high throughput, and high accuracy. To address these limitations, we propose to develop a new imaging platform, the SAFe-nSCAN, which combines multi-scale optical microscopy solutions, from structured illumination microscopy for rapid cell and tissue inspection and classification to single-molecule localization microscopy techniques for deeper and higher nanoscopic 3D information over preselected regions. We will use an innovative chip-based technology developed under the PROCHIP FET-OPEN project (801336) to ensure robustness and accuracy of the measurements. We will validate and deploy this technology in relevant applications, with a focus on immuno-oncology, to advance personalized therapies. The consortium consists of academic partners who will develop the technology, a non-profit association that will facilitate beta testing and promote the technology, and an SME that will collaborate with a new startup company to manufacture chips and bring molecular resolution spatial biology to the market.


**Keywords:** super-resolution; multi-scale; structured illumination microscopy, single molecule localization microscopy; on-chip light modulation; spatial bio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Breeding for a sustainable agriculture: quality and resistance in the frame of H2020' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Plant diseases cause major production and economic losses in agriculture worldwide by reducing yields, lowering quality and decreasing nutritional value. Monitoring health and diseases in plants is critical for sustainable agriculture aiming at providing an adequate supply of food, feed and fiber. Loss reduction is a high priority for European Agriculture, being a pillar of the new H2020 program. Plants possess several complex, highly effective defense mechanisms, to detect and counter invading organisms and stop them before causing extensive damage. These mechanisms must be understood and applied to ensure our food supply and develop highly disease-resistant crops. This understanding will facilitate crop improvement efforts and will reduce considerably the use of chemical products, largely known for their negative impact in health and environment. Breed4Future will exploit the growing number of genome sequences resulting from high throughput DNA sequencing (i) to identify casual genes conferring disease resistance in Compositae and Rosaceae, increasing our fundamental knowledge which will be applied to achieve durable resistance in other species and (ii) to investigate how allelic variation is distributed in genepools of an inbreeding crop and its wild relatives. Thus, a variety of approaches such as NGS, comparative genomics, genome-wide association studies, expression analyses, genetic mapping and bioinformatics will be undertaken. My outgoing host (Genome Center of UC Davis, USA) is a leading genome center in the USA, pioneering the application of genomics approaches to diseases in plants, field which is largely unexplored at CITA (return host, Spain). Consequently, this project fits well with the new competences demanded by the European Research Area of Sustainable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Arctic Domestication: Emplacing Human-Animal Relationships in the Circumpolar North' (2007-2013) under Seventh Framework.

assistant: **Objectives**

This 6-year project aims to co-ordinate field research in each of these fields to elaborate a new model of emplaced human-animal relations evoking recent theoretical concerns of the definition of the person, the attribution of agency, and renewed attention to ‘built environments’.  The project will work inductively from empirical observations in seven field sites across the circumpolar Arctic from the Russian Federation, to Fennoscandia, to Canada.  The circumpolar Arctic originally provided many of the primary thought experiments for classic models of cultural evolution.  It has now again become the focus of powerful debates over the balance between the protection of cultural heritage and the development of natural resources to fuel a future for industrial economies.  The human-non-human relationships chosen for study cover the full range of theoretical and political discourse within the sciences today from primary encounters in domination to contemporary bio-technical innovations in farming.  The team will transcend typical ‘existential’ models of domination between people and animals by describing complex social settings where more than one species interact with the cultural landscape.  The team will also challenge existing definitions between wild and tame by instead examining what links these behaviour types together. Further, the team members will examine how domestication was never a sudden, fleeting intuition but rather a process wherein people and domesticates are sometimes closer and sometimes farther from each other.  Finally, the research team, working within the above mentioned literatures, will develop a renewed model – a new way of describing – these relationships which does not necessarily rely upon metaphors of domination, competition, individual strugg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Maritime Imagination: A Cultural Oceanography of The Netherlands' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In 1609, Dutch jurist Hugo Grotius, commissioned by the VOC, published Mare Liberum. The book argued for a juridical distinction between land-based sovereignties and the ""free sea,"" heralding a new maritime imagination and international legal order that still persists today. Grotius is not just an exemplary figure for early deliberations on maritime worlds, his work carries particular resonance for Dutch articulations of empire and colonialism rooted in oceanic spaces that have shaped its historical and contemporary position in a global context. Although historians agree that The Netherlands was more interested in commercial maritime trade than European settlement, accounts of Dutch empire and colonialism remain land-based, simply mentioning the ocean as a route between colony and metropole. Maritime Imagination addresses this oversight by developing a cultural oceanography of the Dutch maritime imagination, generating an innovative multi-era and interdisciplinary approach to the study of maritime worlds. Applying an oceanic perspective, I aim to show how a maritime frame -rather than a land-based frame- engenders new ways of theorizing the formation of Dutch empire and colonialism and its impact on the present. Starting from an oceanic framework that crosses existing analytic divides between culture, society, law, economy, and environment, I aim to contribute to the emerging interdisciplinary field of Oceanic Studies. Maritime Imagination researches four interrelated ocean temporalities (17th cent. - present), in which I position Dutch ship voyages as laboratories of colonialism and empire. Visions of the ocean, deeds performed at sea, how they are imagined and their impact are what I call maritime imagination, which can only be illuminated by foregrounding the ocean
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Untangling fibroblast plasticity in vascular ageing' (FIB-AGE).

assistant: **Concept**

Vascular ageing is a major cause of cardiovascular disease, but effective treatment for fibrotic effects of vascular ageing is lacking. Recent studies show that fibroblasts exhibit physiological and pathological functions beyond their central role in fibrosis. Supporting this view of the field, the host lab recently showed great intra-vascular fibroblast plasticity in atherosclerotic and ageing murine arteries. We hypothesize that vascular dysfunction and fibrosis with ageing originate from altered fibroblast plasticity and function.As part of my career restart, I will join an excellent laboratory, globally recognized for its expertise in advanced vascular biology research, embedded in a modern research institute, equipped with outstanding training facilities. I will combine my acquired scientific, technical and management skills with the infrastructure and expertise of the host lab to comprehensively study ageing-related fibroblast plasticity and to reveal the function of distinct fibroblast subsets in vascular function and ageing. I will combine the hosts cutting-edge high throughput techniques, including single cell sequencing and a newly established fibroblast functionality screening platform (FIBROSCREEN), with my expertise in vascular contractility assessment. I will study fibroblast function and plasticity in vivo, in vitro and in interventional studies ex vivo, in so far unimaginable detail. By sophisticated integration of this obtained data, I will identify key fibroblast players promoting vascular ageing and dysfunction. With this strategy, I will be the first to reveal subsets of fibroblasts in vascular ageing, to couple their function to vascular ageing progression and to suggest first interventional targets for future exploitation. Together with career guid