RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Integrated high-resolution on-chip structured illumination microscopy'.

assistant: **Objectives**

Fluorescent microscopy is an indispensable tool in biology and medicine that has fueled many breakthroughs in a wide set of sub-domains.Recently the world of microscopy has witnessed a true revolution in terms of increased resolution of fluorescent imaging techniques. To break the intrinsic diffraction limit of the conventional microscope, several advanced super-resolution techniques were developed, some of which have even been awarded with the Nobel Prize in 2014. High resolution microscopy is also responsible for the spectacular cost reduction of DNA sequencing during the last decade.Yet, these techniques remain largely locked-up in specialized laboratories as they require bulky, expensive instrumentation and highly skilled operators.The next big push in microscopy with a large societal impact will come from extremely compact and robust optical systems that will make high-resolution (fluorescence) microscopy highly accessible, enabling both cellular diagnostics at the point of care and the development of compact, cost-effective DNA sequencing instruments, facilitating early diagnosis of cancer and other genomic disorders.IROCSIM will facilitate this next breakthrough by introducing a novel high-resolution imaging platform based entirely on an intimate marriage of active on-chip photonics and CMOS image sensors.This concept will completely eliminate the necessity of standard free-space optical components by integrating specially designed structured optical illumination, illumination modulation, an excitation filter and an image sensor in a single chip.The resulting platform will enable high resolution, fast, robust, zero-maintenance, and inexpensive microscopy with applications reaching from cellomics to DNA sequencing, proteomics, and highly parallelized optical biose
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of low cost flexible moulds for the transformation of composites', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

By means of this project it is intended to develop a process to manufacture low cost flexible semimoulds to produce high consumption composite parts by closed moulding processes. Composites offer important technological benefits in terms of functional character, quality, design versatility, environmental solutions, etc. However, except for sectors where technical requirements (space and aeronautics) are high, the potential applications of composites are not much developed, mainly due to economical reasons. The 60% of the composites moulding processes in Europe are carried out by means of poorly industrialised techniques (hand lay-up and spray-up), which involve hazardous organic volatile emission. In addition, in these processes the quality of the part depends on the skill of the operator. Although composite closed moulding processes are already available, they are not suited to the usual dimension, economical and batch size requirements of sectors of high consumption. The main aim of the project is to develop a process to manufacture flexible semimoulds by means of resins that cure at ambient temperature and that can be easily distributed over a conventional rigid semimould to obtain both shaped sheets or shaped inflatable bags applicable to vacuum moulding, infusion moulding or RTM. At the same time, those moulding processes will need an adaptation to the new semimoulds. The fulfillment of this objective would provide the following advantages to all the sectors involved in the transformation of composites (raw materials producers, transformers and end users):  Environmental improvement: It is intended to reduce organic volatile emission to a quantity lower than 20 ppm. This could help not to close many open moulding production firms which at present do not stay within
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'OsteoMotion: Analyzing the mechanisms and role of osteogenic cell movement in bone development and disease' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Bone development and homeostasis must incontestably rely on a correct spatial positioning of osteoblasts to generate bone at appropriate sites. A failure of osteoblasts to reach the sites in need of bone formation may contribute to impaired fracture repair and osteoporosis. Conversely, uncontrolled osteogenic cell movement may play a role in diseases involving aberrant placement of bone. Mechanisms of osteoblastic migration and adhesion may even be mimicked by bone-metastasizing tumor cells. Yet, the trafficking of osteogenic cells has been a largely neglected aspect in bone biology. My recent studies abroad for the first time shed light on this process in vivo. Newly generated transgenic mouse models for osteoblast lineage tracing revealed that specifically osteoprogenitors, and not mature osteoblasts, moved to initiate novel sites of bone formation. Intriguingly, osteoprogenitors entered developing and healing bones along with their neovascularization, some being wrapped as pericytes around the blood vessels, suggesting an unprecedented vessel-guided cell movement mechanism.Implementing these concepts and models, I here propose two angles to elucidate the mechanisms mediating osteoprogenitor motility. In a first approach, we will assess the involvement, in vitro and in vivo, of known candidate molecular targets of (i) cell-matrix interactions pivotal in cell migration, (ii) cell-cell adhesion, and (iii) the association between pericytes and endothelial cells. Secondly, a high-risk high-gain reverse approach using innovative technologies aims to identify the specific genetic profiles of motile osteoprogenitors and bone-anchored mature osteoblasts.Overall this project will bring novel mechanistic insight in osteogenic cell movement in bone biology and pathology, and add
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '“SURFACE FUNCTIONALISED” CATIONIC LIPOSOME-DNA COMPLEXES CONTAINING PEPTIDE-LIPIDS WITH POLY(ETHYLENE GLYCOL) SPACERS: STRUCTURE, TRANSFECTION EFFICIENCY AND INTERACTIONS WITH THE CYTOSKELETON' to be submitted under Seventh Framework.

assistant: **Abstract**

Cationic lipids (CL) are the most promising candidates for efficient and safe gene-delivery vectors for gene therapy. Compared with viral capsids, CLs do not induce a response from the immune system. Moreover, while viral capsids have a maximum DNA-carrying capacity of about 40 kbp, CLs, which form self-assemblies with distinct lamellar LαC and inverted hexagonal HIIC, or HIC nanostructures when complexed with DNA, place no limit on the size of the DNA.Despite all these promises, transfection efficiency (TE; a measure of the expression of an exogenous gene that is transferred into cells) remains low, and only a substantial increase in the knowledge of relative interactions between CLs, DNA and cell’s components can lead to the design of optimal CL-DNA complexes for gene therapy.Here we propose to design and study novel surface-functionalised PEG-CL-DNA complexes with a RGD and SV 40 peptide sequences. The use of PEG is required to avoid opsin complexation (hence, removal from the organism), while the RGD sequence is expected to induce endocytosis, allowing entrance of the complexes into cells. The SV 40 (a nuclear localisation sequence – NLS) is expected to lead to transport of the smaller sized complexes into the nucleus, permitting the usage of CLs as vectors in slowly or non-dividing cells.To test these hypotheses, transfection studies and confocal microscopy will be carried out in cells, whereas the structures and interactions of the complexes will be characterised with synchrotron x-ray diffraction. The interactions between CLs, DNA and cell components (mainly cytoskeleton filaments and cytoskeletal proteins) will be studied in-vitro with synchrotron x-ray diffraction, confocal microscopy and cryo-transmission electron microscopy.The whole of these studies will per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multidisciplinary approach to airborne pollutant health related issues : modelization with combustion engine exhausts' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The following key questions will be addressed:* Improvement of complex atmosphere continuous sampling for specific in vitro alternative testing developments using both animal and human material risk assessment of global engine exhaust modulation strategies (fuel composition, engine technologies, after-treatment strategies).* Dissection of hazardous engine exhaust components and understanding of their relative contribution to toxicity (gaseous phase, Maize, PM chemical composition).* Comparative assessment of exhausts components in animals with chronic cardio respiratory diseases: allergy, cardiac insufficiency to modeless at risk populations.* Elaboration of strategies based on health/toxicity indicators for developing cleaner engine-fuel-exhaust gas after treatment concepts guaranteeing that harmful components are not emitted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AI for Health: Evaluation of Applications & Datasets', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The proliferation of Artificial Intelligence (AI) is on the rise, and yet, there remains a lack of consensus on standardised approaches for responsible implementation. In Europe, there is a strong push to regulate AI, particularly in high-impact societal applications such as biomedicine and healthcare. The objective of AHEAD is to create a transdisciplinary, diverse and global community drawing on the expertise of professionals in biomedicine, ethics, AI development, software engineering, sociology, psychology, law, gender studies, and relevant stakeholders, dedicated to the ongoing effort of tackling challenges and setting important standards in an ever-changing landscape. Together, the community will gather, consolidate, and put into practice established principles and guidelines, building a methodology and a platform to evaluate AI-based systems for biomedical and healthcare applications to ensure the compliance with legal, ethical, technical, scientific, and regulatory standards. The project will extend the fucntionalities of OpenEBench, ELIXIR’s benchmarking platform for bioinformatics tools, to provide a platform for these assessments. The community will also establish an observatory to collect and curate existing guidelines, best practices, and principles for AI assessment in biomedicine and healthcare across multiple disciplines (technical, societal, legal, etc.). AHEAD will  encourage responsible AI innovation through constant collaboration and knowledge exchanges, to continuously meet the demands of the fast-changing AI landscape and ensure that quality healthcare for all people is never compromised and only enhanced. The proposed project is the beginning of a sustained endeavour that would greatly benefit from mobility grants to enhance community bonds and fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessment of predictive value for cancer of cytogenetic biomarkers used in surveillance of occupationally exposed workers' in the context of a Fourth Framework call.

assistant: **Objectives**

- To pool the data on cytogenetic scoring and cancer and cardiovascular mortality from a Nordic and an Italian cohort in order to facilitate more detailed assessments of the predictive value of cytogenetic tests.- To perform a cohort based case-referent study that aim to determine whether the association between cytogenetic endpoints and cancer risk depends on (specific) exposures.Cytogenetic tests on peripheral blood lymphocytes from exposed workers have since 2-3 decades been used in occupational health surveillance programmes in order to assess genotoxic risks. It is postulated, but not proven, that increased cytogenetic damage may reflect an enhanced cancer risk. It is important to clarify this matter, as a firm knowledge of the predictive value of early biomarkers for genotoxicity may become an important tool when implementing preventive measures for increasing the safety and health protection of workers. Preliminary results from a Nordic and an Italian study, show a positive trend between the frequency of chromosomal aberrations (CA) and increased cancer risk. A pooled analysis of follow-up data from these two cohorts would substantially increase the statistical power, and make a more detailed assessment feasible earlier than otherwise possible.The Nordic cohort comprises 3182 adult individuals cytogenetically examined during 1970 to 1988, in Denmark, Finland, Norway and Sweden, because of mainly occupational exposure to mutagens or carcinogens, or they were tested as unexposed referents. The Italian cohort comprises 3500 subjects cytogenetically examined for similar reasons 1965 to 1993. A further follow up will comprise cancer incidence/mortality data up to 1993-1995. A cohort based case-referent study on various cancer diagnoses, considering occupational exposu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hybrid Networked Control for Microgrids' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

To promote the EU’s sustainable environmental development and decarbonization, increasing distributed renewable energy sources (DRESs) are desirable to be integrated into power grids. Microgrids, as one kind of promising means to integrate DRESs with power electronics technologies, have great potential in future power grids. However, due to the lack of physical inertia, the stable operation of power-electronics-dominated microgrids is suffering significant challenges. The HNCM project is proposed in the context of solving these challenges by providing some scientific foundations that enable the efficient operation of low-inertia microgrids, with particular focus on hybrid modeling, stability analysis, and control design. First, new hybrid models will be set up by incorporating physical properties of each distributed generator (DG) and their interactions with electrical networks. Then, new stability analysis criteria for general microgrids will be derived with the expected dynamic performance by designing electrical-parameter-dependent Lyapunov functions. Finally, flexible distributed robust control approaches will be developed under multi-agent architectures with time-varying interaction topologies among DGs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Ethics of Oil: Finance Moralities and Environmental Politics in the Global Oil Economy'.

assistant: **Concept**

In October 2014, the Chairman of the Bank of England Mark Carney warned that many oil reserves cannot be developed. If so, they would contribute so significantly to increased greenhouse gas emissions that international targets to avoid dangerous levels of global warming would be exceeded. However, stock valuations of oil companies assume that all proven and probable reserves can indeed be produced. Amounting to a potentially enormous debt overhang, the Bank of England has launched an enquiry into the threat of a crisis similar to the subprime mortgage crash, known as the ‘carbon bubble’. This looming crisis with its ‘stranded assets’ raises urgent questions about the conflicting dynamics between finance moralities and environmental politics at a time of oil dependency and an uncertain climate future. Grounded in ethnographic fieldwork with oil companies in the US and Norway, energy analysts in the UK and the US, and fossil fuel divestment movements in Germany and the UK, ENERGY ETHICS will develop a new framework for understanding the relationship between oil, money and climate change that counters the prevalent tendency to interpret these issues through aggregated normative systemic analysis only. Taking its starting point in people’s own perceptions of and direct involvement in the oil economy, it will offer a major step forward in understanding how people in positions of influence within the oil economy make financial and ethical valuations of oil. This will contribute to public stakeholder dialogue and wider transdisciplinary engagements. Focusing on oil and its financialization, ENERGY ETHICS has three main research objectives: 1) to examine how people positioned strategically in relation to the global production of oil conceptualise and influence the oil market; 2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterization of the role of histone H1 and its post-translational modifications in the functional regulation of chromatin' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Histone H1 participates in both the establishment and stabilization of high-order of chromatin organization through its binding to the internucleosomal DNA. H1 seems to play an important role in regulation of chromatin functions, and particularly in the regulation of gene expression and chromosome condensation.However, our understanding of H1 function is based mainly on in vitro studies and we do not understand completely how H1 exerts it function in vivo or how it coordinates with the rest of the chromatin machinery. This is in part a consequence of the high complexity of H1 present in the majority of eukaryotes analyzed so far.The existence of multiple isoforms together with intrinsic difficulties to develop specific antibodies against each one of them, hinders enormously the study of H1 contribution to chromatin regulation in vivo. Histone H1, like the rest of histones, is regulated by certain post-translational modifications. However, we still do not know the whole set of modifications of H1 and their functional relevance in control of epigenetic phenomena of transcriptional regulation, chromatin structure, cell cycle control and differentiation.This project aims to elucidate the in vivo role of histone H1 and its post-translational modifications in the regulation of chromatin functions. We intend to use Drosophila melanogaster as experimental model for our studies, since in contrast to vertebrates and some other Drosophila species, the D. melanogaster multi-copy gene His1 codifies for a single isoform. Additionally, Drosophila offers obvious technical advantages from a biochemical and genetic point of view.The aim of the project will be achieved by different approaches like the identification and in vivo and in vitro characterization of post-translational modificat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Spray protection with low application technology'.

assistant: **Innovation**

Spraying is felt to entail risks from residues and harm to wildlife yet is vital as adjunct to crop production for mass markets. Costs of chemicals have killed farming margins whilst residue removal is a burden on potable water supplies. SPRAY halves drift with standard drops and sustain standard drift with halved drops, suggesting 1/8th volume should suffice with acceptable drift subject to satisfactory penetration. Organic options alone won't suffice as solution, so SPRAY offers an EC (O) LEAN 3rd way to shelf produce from cleaner practices, plus savings in chemical costs which account for upwards 1/3rd produce price paid to arable farmers. Evaluations are needed in crop canopies, scooping to biological assessments meeting sector protocols. Licensed by IPR- holding SME SPLAT Coordinator, SPRAY systems will be made by one SME Propose for evaluation by another and by other producers in the farming sector dominantly serviced by Sees for benefits also from increased application flexibility. The deliverable will be verified spraying systems with proven ruggedisation in field uses.