RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'DIVerse Exoplanet Redox State Estimations'.

assistant: **Concept**

New observational capabilities with the JWST and ARIEL space telescopes will strongly advance our ability to characterize exoplanetary atmospheres. While the community focusses mainly on biosignatures, in DIVERSE I will search for signatures of geophysical factors that influence habitability, specifically the diversity of planetary redox states. The redox state is of major importance for habitability, since reducing conditions favour prebiotic chemistry for life as we know it. Atmospheres of rocky planets are typically divided into two distinct classes – H2/He-dominated (reduced) atmospheres of primordial origin – here denoted as Class I planets – or secondary (more oxidized) atmospheres of volcanic origin – here named Class II planets. In the Solar System, observations are limited to old, evolved atmospheres that became oxidized over time and do not allow to directly constrain the planets’ interior redox states. Furthermore, detection of reduced species such as CO or CH4 does not unambiguously link back to the interior redox state.In contrast, if we were able to detect H2-dominated atmospheres lacking He – here called Class X planets – the most likely explanation would be strongly reduced degassing from the magma ocean or subsequent volcanism. Distinguishing Class I and X planets would truly allow to constrain the planetary redox state and indicate how it depends on observables such as stellar composition or planetary mass. Estimates on the distribution and observability of Class X planets are yet missing but became recently possible. DIVERSE will build strong predictive, theoretical models, linking the interior evolution including core formation with atmospheric abundance and erosion models including the observability potential, to determine the diverse evolution path
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Delineation of molecular mechanisms underlying the establishment and breakdown of immunological tolerance in the thymus' (ThymusTolerance) under Horizon 2020.

assistant: **Objectives**

Central tolerance is shaped in the thymus, a primary lymphoid organ, where immature T lymphocytes are “educated” into mature cells, capable of recognizing foreign antigens, while tolerating the body’s own components. This process is driven mainly by two separate lineages of thymic epithelial cells (TECs), the cortical (cTEC) and the medullary (mTEC). While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T (Treg) cells. Crucial to the key role of mTECs in the screening of self-reactive T cell clones, is their unique capacity to promiscuously express and present almost all self-antigens, including thousands of tissue-specific antigen (TSA) genes. Strikingly, the expression of most of this TSA repertoire in mTECs is regulated by a single transcriptional regulator called Aire. Indeed, Aire deficiency in mice and human patients results to multi-organ autoimmunity. Although there has been dramatic progress in our understanding of how thymic epithelial cells shape and govern the establishment of adaptive immunity and of immunological self-tolerance, there are still several outstanding questions with no comprehensive answers. Therefore, in the research proposed herein, we wish to provide more comprehensive answers to these still elusive, but very fundamental questions. Specifically we will aim at: 1.) Delineation of molecular mechanisms controlling TEC development and thymus organogenesis; 2.) Delineation of molecular mechanisms underlying promiscuous gene expression in the thymus; 3.) Identification and characterization of molecular determinants responsible for the breakdown of thymus-dependent self-tolerance. To this end, we will build upon our rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Asas thematic network'.

assistant: **Objectives**

The main ASAS Thematic Network outputs consist in the sharing of the current knowledge on ASAS between all European stakeholders and in recommendations for future activities required to reach the operational use of ASAS applications. It is expected that these results will be of use to guide future EC actions from 6th Framework RTD projects to shorter-term TEN-T pre-operational experimentations. The expectation is also that the shared knowledge and the agreed upon recommendations will allow European industry to optimally plan and focus their new products development strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanism Identification and High-Throughput Screening of Molecules for the Hydrogen Evolution Reaction' (MIGHTER) targeting Horizon Europe.

assistant: **Abstract**

The electrocatalytic hydrogen evolution reaction (HER) plays an important role in sustainable hydrogen energy conversion. Organic molecules, as potential alternatives to expensive Pt-based metals, can significantly reduce the cost of  catalysts. However, the HER mechanism of organic molecules in aqueous solutions is poorly understood. The unclear structure-mechanism relationship hinders the discovery of efficient molecular catalysts. This project systematically investigates the HER mechanism of organic molecules under both acidic and alkaline conditions through Density Functional Theory (DFT) calculations and microkinetic models. Subsequently, structural descriptors are developed to capture the structure-activity relationships of organic molecules. High-throughput screening based on these descriptors is employed to identify promising HER catalysts from millions of molecules through machine learning approaches. These active candidates are further validated through theoretical calculations and experimental measurements. By combining mechanism analysis, descriptor construction, high-throughput screening, and validation, the workflow not only identifies new molecular catalysts for HER, but also provides a valuable framework for screening and discovering other materials.


**Keywords:** High-throughput screening
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Comparison of the gene regulatory programs of blood stem cells and megakaryocytes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Blood stem cells provide the constant supply of new blood cells throughout a person’s lifetime. Their transcriptional regulation, i.e. the fine tuning of which genes should be active at any given time, is critical for their normal function. Moreover, a large number of leukaemias arise, when this fine balance of gene activities is disturbed. However, very little is known about the molecular mechanisms responsible for setting the appropriate gene activities in blood stem cells. Transcription factors are responsible for controlling the activity of other genes and many of the transcription factors important for the normal function of blood stem cells are also active in the cell that forms blood platelets, the megakaryocyte. This proposal aims to compare the gene regulatory programs of blood stem cells and megakaryocytes. The focus will be on a triad of regulatory transcription factors: Gata2/Fli1/Scl, which have recently been shown to be essential for the development of blood cells during embryogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Commercialisation of Advanced Composite Material Technology: Carbon-Glass Hybrid in PowderEpoxy for Large (60-100m) Wind Turbine Blades' to be submitted under Horizon 2020.

assistant: **Abstract**

POWDERBLADE aims to gain market acceptance and rapid market take up of an innovative materials technology involvingcarbon/glass fibres in powder epoxy to be commercialised initially in the production of larger wind turbine blades (60 metre+). The immediate impact of this disruptive materials technology in the wind energy sector will be reduced wind turbine cost(-20%). This in turn will lead to increased productivity of low-carbon energy from more rapid market deployment of largeturbines. The reduction in costs and increase in productivity will reduce the Levelised Cost of Electricity (LCOE) for theEuropean citizen – the ultimate beneficiary of this innovation.This ambitious project is led by Éire Composites, an established industry player in composites manufacturing for theAerospace and Renewable sectors and an experienced FP7/Horizon 2020 participant.In the year after project end,ÉireComposites will generate over €7m in revenue from direct sales of larger blade components using the new materials,increasing to €39m by 2021. The longer term commercial strategy is to focus on recurring revenues from the supply ofadvanced materials directly to manufacturers to produce blades and other products under license. This revenue stream willgenerate €60m by 2021. ÉireComposites will employ an additional 78 staff in direct production at project end increasing to489 employees over both revenue streams three years later.Suzlon, a large wind OEM and end user, is the second industry partner. Their involvement demonstrates early marketacceptance of the new technology. Suzlon are committed to investing substantial funds in the commercialisation of thistechnology in return for the opportunity to gain significantly as the first large industry player to market with light, cost-effectivecarbo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Illuminating the enteroviral life cycle'.

assistant: **Objectives**

Enteroviruses are highly prevalent pathogens that have enormous clinical and socio-economic impact. Well-known examples are poliovirus, coxsackievirus, enterovirus-A71, enterovirus-D68, and rhinovirus. Although important insights have been obtained in the enteroviral life cycle, many important questions remain unanswered due to shortcomings of current imaging and biochemical methodologies. There is a high need for novel technologies that allow sensitive and real-time observation of the dynamics and localisation of viral RNA, viral proteins, and host factors at the single-cell level. My long-term goal is to understand enterovirus replication and translate knowledge into the development of antiviral drugs. My lab has a long-standing track record and has made many important contributions to understanding the molecular mechanisms of enterovirus replication and the formation of viral replication organelles. Recently, we constructed a reporter virus that in combination with high-resolution microscopy allowed for the first time to visualize translation, and the regulation thereof, of single (entero)viral RNAs in living cells. The goal of this project is to visualize and dissect the spatial and temporal regulation of different phases of the enterovirus life cycle. As a first step, novel recombinant reporter viruses for application in real-time imaging technologies will be developed. These viruses will be used to study viral RNA replication, virus assembly, and pre-lytic virus release in living cells. Moreover, they will be instrumental to study the structure and composition of the viral replication organelles and the associated replication complexes through advanced cryo-electron microscopy and tomography technologies, and proteomics/lipidomics analysis, respectively.This proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unraveling key abiotic and biotic interactions for sustainable anaerobic biotransformation of chlorinated solvents in groundwater' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Chlorinated solvents are potential carcinogens frequently found in groundwater and are classified as priority pollutants. Anaerobic biotransformation of these compounds to non-toxic ethene via reductive dechlorationation is carried out by microorganisms living in consortia. Bioaugmentation – the addition of active microbial cultures to a contaminated site – is a low-cost and potentially highly effective remediation alternative, particularly for chlorinated solvents, where dechlorination is carried out by very specialized microbes not present at every site. However, there remain serious scientific gaps to more widespread adoption of bioremediation and bioaugmentation. Diagnostics and prognostic monitoring approaches are critically needed to improve our ability to sustain high rates of microbial activity and make bioremediation more reliable and more predictable. This project aims at providing new insights into the biogeochemical interactions affecting chlorinated solvent bioremediation in subsurface anaerobic environments. A stable microbial consortium (KB-1) developed in the Edwards’ lab (Univ. of Toronto) and used commercially for bioaugmentation at field sites will be used as a model for lab-based and field experiments. The project will address three major issues: a) unravel contaminant metabolism and important interspecies interactions in mixed microbial communities with the help of metagenome sequences and metabolomic profiling, b) identify biomarkers through molecular screens and isotopic fractionation signatures to monitor biodegradative mechanisms and the key players involved in these processes and c) understand critical abiotic-biotic interactions and physiological influences on microbial activity in the subsurface at contaminated sites. Knowledge gained from th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrative Approaches to Dental Wear: Non-Masticatory Tooth-Use Across the Mesolithic-Neolithic Transition Among Iberian Foraging and Farming Societies' in the context of a Horizon 2020 call.

assistant: **Objectives**

The IDENTITIES project investigates human dental wear related to the non-masticatory use of the dentition (the habitual use of “teeth-as-tools”) among human groups that span the Mesolithic-Neolithic Transition in the Iberian Peninsula – a period of complex social, economic, and technological reorganization corresponding to a shift from hunting and gathering to a dependence on domesticated plants and animals. A lifetime of using the teeth for habitual, manipulative tasks leaves distinct traces on enamel, and these idiosyncratic patterns of wear provide biocultural markers of social identities when aligned with information on sex, age, occupation, or status of individuals across archaeological samples. Human dental remains from archaeological sites across the Iberia provide an ideal regional focus for exploring biocultural changes related to tooth-use during a crucial prehistoric socioeconomic transition. IDENTITIES is interdisciplinary, bringing together experts in microscopy, experimental methods, bio/archaeology, and paleoanthropology through an integrative methodology to document non-masticatory dental wear. The methodologies include recent advances in Gigapixel-like imaging strategies, confocal and scanning electron microscopy, and three-dimensional dental topographic methods to analyze experimentally-worn and archaeological samples. The integrative methodology was also established to cross-validate each method (presently an unresolved issue), and advance the study of material surface modification of biological and archaeological materials generally. In addition to providing an intellectual impact through methodological advances, the same data will directly address how biocultural changes in non-masticatory tooth-use reflect changing social identities across archaeol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Radiative transport and the dynamics of diffuse astrophysical sources', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

I will use analytic and numerical techniques that I have already developed to pro- duce and propose diagnostics of physical conditions in various astrophysical envi- ronments using E2O and OH maser lines. The environments are a) disks around central black holes in Active Galactic Nuclei, b) outflows of evolved stars, c) super- nova remnants and d) Herbig-Haro objects. I will also use my expertise in radiative transfer to determine the limits of what can be learned about protostellar infall from existing millimeter wave molecular emission features. Finally, I will either investigate the effects of magnetic coupling between different layers in an evolved star's outflow on the mass loss rate and wind terminal speed or the response of a spherical clump to the turn-on of an ionizing stellar radiation. A realistic diffuse component of the ionizing radiation will be included and the development of a cometary-like structure will be examined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced biomarker discovery for earlier diagnosis and improved prognosis of NAFLD stages via high resolution mass spectrometry.' (RENAISSANCE).

assistant: **Innovation**

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of nearly 25% i.e., affects one quarter of the adult population. Early phase NAFLD is reversible and can be treated, but it may progress towards life-threatening stages such as non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The conventional diagnosis of NAFLD stages requires liver biopsy and is time-consuming and costly and there is an urgent need to identify biomarkers that can be applied in routine clinical settings, such as through blood-based testing. The identification of blood biomarkers would support earlier diagnosis and improved assessment of prognosis, ultimately supporting preventive/intervention measures to avoid progression to late stage liver disease and thus saving lives. In RENAISSANCE, a state-of-the-art liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomics screening will be conducted upon the blood and blood-derived exosomes of a unique deeply phenotyped cohort of NAFLD patients for molecular biomarker discovery. Notably, exosome analysis shows promise for the identification of novel disease signatures but has yet to be applied to characterize NAFLD, providing high potential for the identification of new diagnostic/prognostic biomarkers for NAFLD. Furthermore, the LC-HRMS screen will be supported via targeted assays of redox metabolites and protein markers of acute inflammation. The integration of non-target and target data will provide insight into the underlying mechanisms of disease progression and further knowledge about potential causative factors of NAFLD.


**Keywords:** NAFLD, metabolomics, biomarker discovery, liver diseases, NASH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Beyond Abelian T-duality' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Abelian T-duality is a well-known symmetry of String theory for space-times admitting an Abelian isometry. Less well appreciated is the fact these dualities can be generalised to space-times with non-Abelian and fermionic isometries. While these are not full symmetries of String theory, they still are symmetries of the effective String theory action, namely type II supergravity. One long-standing problem with non-Abelian T-duality is the identification of the dual conformal field theory (CFT), a problem that plagues non-Abelian dualities in general. In contrast, fermionic T-duality has been shown to be intimately related to the hidden symmetries seen in scattering amplitudes, though only for the isolated example of maximally supersymmetric super-Yang-Mills in four space-time dimensions. So, this work aims to address both these shortcomings by identifying the dual CFT for non-Abelian T-duality and finding symmetries of scattering amplitudes in other theories that can be accounted for through fermionic T-duality. Furthermore, we will also investigate the phenomenological and cosmological implications of these symmetries.