RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Protection of reperfused myocardium against lethal mechanical injury' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

This project aims at causal analysis and development of a therapeutic strategy for acute reperfusion injury. The first aim is to elucidate the mechanisms responsible for mechanical cellular injury. The second aim is to develop a therapeutic strategy to limit this Injury.Ischemic heart disease is the leading cause of death in Europe. The extent of myocardial necrosis caused by acute coronary occlusion depends on damage developed during ischemia and during reperfusion, following spontaneous or therapeutic recanalization. There is increasing evidence that during the acute phase of reperfusion severe cellular damage, additional to the one manifested during ischemia, develops due to mechanical causes.The project will combine methods and skills of three different laboratories within the European Union, two of which were partners in a previous, successful BIOMED-I project, to attain its objectives. The workplan considers the following 6 intermediate targets:1. Sarcolemmal fragility is increased in reoxygenated cardiomyocytes. The importance of lipid peroxidation and disruption of the cytoskeletal anchoring of the sarcolemma will be investigated.2. The role of uncontrolled force generation in reoxygenated cardiomyocytes, caused by elevated cytosolic Ca2+ levels, will be analyzed.3. The causes for increased susceptibility of the myofibrils to develop hypercontracture will be studied in reoxygenated cardiomyocytes.4. based on the previous causal analysis a composite strategy of therapeutic means will be developed for ischemic-reperfused myocardium in vivo (pig model).5. In cardiomyocytes, saved from mechanical injury during early reperfusion, the consequences of gene expression in long-term recovery will be studied.6. It will be investigated whether prevention of early reperfusio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multidisciplinary Institute for Ageing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project describes a teaming partnership between the University of Coimbra (UC) (partner in a low-performing country) and the University of Newcastle (UNEW) (partner in a high-performing country) to create, in Coimbra, a new Centre of Excellence in Ageing Research - the Coimbra Multidisciplinary Institute of Ageing (MIA). This flagship project for the Centro Region of Portugal is aligned with the regional RIS3 and will be coordinated by the regional authority CCDRC (strategic coordinator) and by UC (operational coordinator).The Newcastle University Institute for Ageing (NUIA) is one of the largest and longest established institutions in translational ageing research worldwide. In this teaming project, NUIA is supported by two further world-leading centres in translational ageing research; the University Medical Center Groningen (UMCG) and the Mayo Clinic Robert and Arlene Kogod Center on Aging.European Member states are committed to increase human healthy life expectancy by two years on average by 2020. Present increases in healthy life expectancy are largely due to increasing differences in ageing rates between member states, regions, communities and individuals. This massively worsens socioeconomic inequalities. Recent progress in understanding the mechanisms of ageing suggests that social, lifestyle, nutritional and pharmaceutical interventions can, effectively, reduce these differences by targeting the faster ageing members of the population.The overall objective of the new Centre for Excellence is to improve health and wellbeing of an ageing population. It will gain a forefront position in ageing research and develop, validate and deliver interventions that can improve human healthy life expectancy. It will train young researchers and engage the public in suppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'USE OF INNOVATIVE THERMAL ENERGY STORAGE FOR MARKED ENERGY SAVINGS AND SIGNIFICANT LOWERING OF CO2 EMISSIONS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

INNOSTORAGE proposal is driven by the need to develop efficient thermal storage (TES) systems using phase change materials (PCM). One of the main contributions to the rational use of energy is given by the TES systems. They accommodate efficient storage of thermal energy, promoting the possibility of using renewable energy such as solar energy, ambient cold and residual heat. The use of PCM for TES is the system that has aroused more practical interest, due to their large energy storage density available within a narrow temperature range. In this project we aim to study means of improving the development of the constituent PCM, their encapsulation and use in a number of important applications in both the domestic and industrial sectors, with the final aim of achieving commercialization in the European market. The implementation of these storage systems may lead to marked energy savings and significant lowering of CO2 emission.The research scheme considers the expertise and capabilities of each partner and also the possibility of creating new synergies among them. It will be implemented through 7 work packages covering the objectives of new materials, with special emphasis to cost, and the characterization of their thermophysical properties. It will also cover the modelling of materials and systems, and their applications in industry and in PCM in construction elements. The proposed exchanged program includes visits of experts and ESRs in all the work packages with the overall aim of extend, enhance and strengthen established collaboration among the INNOSTORAGE partners, increasing the individual mobility and career prospects of each researcher. These exchanges will involve a transfer of knowledge at different levels and training opportunities for ESRs searching the futu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'BIODIVERSITY AND ECOSYSTEM FUNCTIONING: individual-based modelling to understand and predict the consequences of biological invasions' (InvaBioEcoF) targeting Seventh Framework.

assistant: **Abstract**

Human activities and global changes are increasingly impacting biodiversity and the functioning of ecosystems. The ability of ecologists to determine how threatened communities and ecosystems will respond to these changes is crucial for conservation management and the setting of European environmental policy. Yet, our ability to determine how ecosystems may respond to such changes is limited, despite ecologists frequently being requested to provide policy makers with predictions. The aim of the project is to understand how non-random alteration of biodiversity by perturbations may affect ecosystem functioning, using invasive top-predatory fish as a non-random perturbation. Given their crucial role in food-webs and their high economical and social value, they are excellent candidates to investigate this question. The specific objectives are to use individual-based modelling to investigate some hypotheses related to biodiversity and ecosystem functioning and generate empirically testable predictions. After testing these predictions, the model will used to determine the consequences of scenarios of biological invasions. To achieve these objectives, model simulations, field investigations and experimentations in small lakes will be conducted. Data collection will be based on an innovative approach utilising state-of-the-art techniques (individual tagging, telemetry and stable isotope analyses). To maximize the opportunity for successful completion, the Fellowship will be nested within, and will receive complementary skills from the host organization, Universite Paul Sabatier (Toulouse, France). Using skills acquired during the previous Marie Curie fellowship and continuing collaboration with the previous host institution (Bournemouth University, UK), completion of the fello
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ethical, legal and social aspects of human genetic databases. a european comparison', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The ELSAGEN project consists in- Providing knowledge of ETHICAL, LEGAL and SOCIAL aspects of population-based HUMAN GENETIC DATABASES, anticipating and addressing questions raised by recent developments in genetics research.- Informing the SOCIAL DIALOGUE, raising awareness and improving BIOETHICS EDUCATION in the countries where human genetic databases are being constructed.-Consulting the public about issues of PRIVACY of genetic and medical data, by conducting a SURVEY in the four countries.- Composing ETHICAL GUIDELINES for human Genetic Databases, informing decision and policy makers on national and European levels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Chemical Enrichment of the Intergalactic Medium' to be submitted under Sixth Framework.

assistant: **Abstract**

The tenuous medium in between galaxies contains most of the matter in the universe. The enrichment of this intergalactic medium (IGM) with elements heavier than helium, which are all formed in stars, is closely related to several questions central to astrophysical cosmology. We propose to carry out a 4-year research program that will provide accurate measurements of the abundances of heavy elements in the IGM and a much better understanding of feedback from star formation, the most poorly understood aspect of galaxy formation. We will also gain insight into the nature of the first stars, the relative importance of starlight and light from accretion flows onto black holes, and the mechanism by which heavy elements are dispersed throughout the universe. We will adopt an innovative, multi-disciplinary approach, making use of both high-quality observations and state-of-the-art numerical simulations. We will carry out global analyses of quasar absorption spectra using novel techniques, as well as studies of absorption by individual, highly enriched, intergalactic gas clouds. The former will be interpreted using cosmological simulations, while the latter will be compared with targeted simulations of various astrophysical phenomena. The required observations and access to high-performance computers have already been secured.Our team will consist of the team leader (Schaye), one doctoral student, one post-doc, who will all be based at Leiden Observatory in the Netherlands, and several experienced researchers who will visit Leiden for up to one month per year. We will make special efforts to maximise the national and gender diversity of the team. The award of a Grant to this team would:(1) Enable the formation of a European team which will carry out cutting-edge, interdisciplina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neural mechanisms, functional roles and pathophysiological relevance of human grid cell-like representations' under Horizon 2020.

assistant: **Concept**

The entorhinal cortex contains grid cells, a major cell type underlying spatial navigation. At the same time, it is amongst the first areas of the brain to be affected by Alzheimer’s disease (AD). In humans, grid cell-like representations (GCLRs) have been proposed as a network-level signature of grid cells that can be recorded non-invasively via functional magnetic resonance imaging (fMRI). I have recently demonstrated that there is a disruption of GCLRs in genetic AD risk carriers at young age, and suggested GCLRs as a novel biomarker for early disease processes in AD. However, the relationship between GCLRs at a network level and grid cells measured at the single-neuron level is still unknown, as is the pathophysiological relevance of the impaired GCLRs and of compensatory hyperactivity in other navigational systems. In the translational research program proposed here, I aim to unravel the cellular mechanisms, functional relevance, and pathological impact of grid cell-like representations in humans. My specific objectives are to (1) provide the first validation of GCLRs, by directly relating GCLRs at the network level to single unit activity of individual neurons recorded via microelectrodes in epilepsy patients; (2) clarify the functional relevance of GCLRs and complementary navigational systems for spatial behavior via layer-resolved ultrahigh field (7T) fMRI; (3) determine whether impairments of GCLRs and compensatory recruitment of other navigational strategies are related to AD pathology, using tau- and amyloid-PET imaging in AD risk carriers; and (4) restore impaired GCLRs via a pharmacological intervention, which may constitute a novel therapeutic option for modifying early AD. These studies will provide the first detailed understanding of the neural mechanism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Observational Signatures of planet formation in externally IRradiated dIScs'.

assistant: **Objectives**

Star and planet formation typically occurs in star forming regions more massive than the nearby, low-mass regions that have been the main focus of observational studies of protoplanetary discs. In massive regions, irradiation by neighbouring massive stars can heat this protoplanetary disc of dust and gas, from which planets form. This heating drives thermal winds that extract dust and gas, reducing the mass available for planet formation. In typical star and planet forming environments, these winds are sufficient to drastically change the outcome of planet formation. However, this consideration is currently missing from models. Further, we are yet to find observational evidence of planet formation in the strongly externally irradiated discs that are the most common. These advances are essential steps in understanding the properties of exoplanets, and in uncovering the key processes that govern their formation. During this project, I will make new calculations of the mass-loss rates for irradiated discs as small dust grains are processed into planets. I will then use semi-analytic computational modelling to investigate how the process of planet formation differs in externally irradiated environments compared to non-irradiated environments. I will compare these models to state of the art observations of protoplanetary discs, putting constraints on the physics of disc evolution. Finally, I will run hydrodynamic and radiative transfer calculations to make predictions for observational searches for planets in irradiated environments. These efforts are essential for understanding how planet formation proceeds in typical star formation environments. In this way, I will unveil how the star formation environment sculpts the observed exoplanet population.


**Keywords:** planet f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Study of DNA and RNA structures with Matrix Theory' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Many aspects of DNA and RNA biological functions depend on their peculiar three-dimensional structure. The complete prediction of the actual structure from their base sequence is a challenging open problem. Recently Random Matrix Theory (RMT) has been proposed as the key for a possible solution. Objectives:-Extensive application of all well-known RMT techniques to the study, modelling, and description of the 3D- structure of RNA and DNA. -Designing and production of new numerical algorithms and computer programs for the prediction of 3D- structures of RNA and DNA, given the sequence of bases.-Monte Carlo simulations of the matrix models for RNA and DNA. Study of thermodynamically properties, phase diagram and possible existence of glassy phases.-Information theoretic issues and applications to combinatorial optimisation problems. Method: RMT is a classical tool of theoretical physics, which provides a natural mathematical framework for studying the interplay between fluctuating geometrical objects and their topological classification. Hence it can be used for a systematic classification and description of the complex folding of biopolymer structures according to their topological character. It gives control over their thermodynamically properties, and it leads to a number of new approximation schemes and hence to computer programs of new concepts for the prediction of the structural properties of DNA and RNA.The work will be both theoretical and numerical. Relevance:-The highly innovative profile of this project,-the excellence of the host institution on RMT and applications to biophysics,-the profound experience of the applicant with RMT and the possibility to widen his knowledge in bimolecular physics by means of a high-level Research Training. All the above fits very
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Benchmarking of environmental sustainability research in the eu and accession countries' under Fifth Framework.

assistant: **Concept**

The ICOS study aims to provide recommendations for the improvement of coordination between actors at various levels (EU, national, regional), active in various aspects (policy making, policy delivery, conducting research, advisory boards, policy influencing organisations) of research in the field of environment and sustainable development. One of the main features of the project is the dialogue with these actors and their participation in the development of recommendations. The development of recommendations will be mainly done during national workshops that will be organised in each of the 15 EU Member States. The overall results of the project will be presented and discussed during a validation seminar in Brussels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Breakthrough European tEchnologies Yielding cOnstruction sovereigNty, Diversity & Efficiency of ResourceS' (BEEYONDERS) under Horizon Europe.

assistant: **Objectives**

Demographic trends in Europe are posing a challenge to the construction sector, which is facing labour shortage, and an aging existing workforce. This can be addressed through the integrated adoption of breakthrough technologies, e.g. autonomous vehicles, collaborative robotics, additive manufacturing, smart wearables, digital twin, and artificial intelligence, which can help to get construction tasks done with more efficacy, while at the same time making the sector more attractive to young people, and improving the safety, productivity, quality and environmental impact of construction projects. BEEYONDERS will take a leap forward in the design, development, and integration of these breakthrough technologies in real construction scenarios, bringing together the capabilities of European stakeholders, thus also demonstrating how the dependency on technology import from outside Europe can be reduced. Solutions will be developed for supporting the integration of autonomous and tele-operated, ground and aerial robotic platforms and heavy equipment in harsh environments. Innovative additive manufacturing solutions will be developed for resource optimization and for protection of biodiversity in maritime works. Safety, wellbeing, and training of workers will be improved through the development of exoskeletons, advanced wearables, and learning resources supported by XR technologies. A Digital Twin enriched with AI-based layers for decision-making will support seamless integration and management of all Project technologies. These will be tested and validated in 6 demonstration case studies covering different project typologies: tunnels, earthworks for road construction, buildings, maritime infrastructures, and road maintenance. BEEYONDERS impact will be evaluated both from the p