RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Local development cooperation actions enabled by semantic technology' (LD-CAST) targeting Sixth Framework.

assistant: **Abstract**

The project aims at enabling cross border cooperation between European chambers of commerce (CC)in order to support the development of private company initiatives. The project will build a European network of LD-CAST Portals that will enable end users(mainly private companies)to access in a seamless mode the services provided by public organisations registered in each LD-CAST portal.This network will be accompanied by a coherent framework for realizing and exploiting one-stop model platforms at all levels (European, national, regional and local) compliant with the European Interoperability Framework(EIF)guidelines without requiring specific changes in working procedures and systems of the participating organisations.In order to facilitate the interoperability between different CCs acting as service providers, a common ontology will be defined to model processes, services and different types of requests. Processes will be modelled according to the business episodes paradigm. Reuse and larger deployment will be facilitated by building common knowledge and vocabularies for business episode based modelling of cross-border processes and by allowing localisation of the service and process definitions with local constraints and rules.The project Consortium will build a prototype in order to demonstrate how LD-CAST can support all the chain, including service and process modelling, service publication, service discovery, process composition and execution.The project Consortium spans over the different involved countries. A high scientific contribution is required (to Universities and the research institutes) for the definition of the ontologies and process modelling. CCs will act as service providers and support the definition of the processes and services to be addressed. Tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A kinesthetically controlled robotic system for diagnostic purposes in orthopaedics' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The Scientific and Technical Objectives of this research proposal concern the development of a qt very new diagnostic methodology based on a computer controlled robotic device designed to meet paedic requirements for an advanced examination and treatment of injuries. The research is required to conduct both medical and technical assessment of the application of ad robot control concepts based on kinesthetic sensing in human orthopaedics diagnostics. Particularly rest is focused on the low extremity joints (ankle, knee and hip) where injuries are frequent and in difficult differential diagnosis. Development of new technologies to assist early diagnostics and treatment of joint injuries, thereby ving the medical outcomes, has a large common economic and social interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Digital Design strategies to certify and mAnufacture Robust cOmposite sTructures' in the context of a Horizon Europe call.

assistant: **Objectives**

New certified designs for structures are critical for the new upcoming changes in conception of aircraft architectures. A variety of breakthrough designs and new strategies for a better use of material and integration of functions in aircrafts are required. They range from regional electrical mobility solutions to increased aspect ratio wings that will bring higher flexibility in structures. Digital conception and simulation need to play an ever-bigger role to reach a certified design that includes production scenarii before full manufacturing. High-end simulation is a spearhead research activity present in many fundamental and applied research activities. The level of complexity of phenomena being solved through dedicated modeling techniques is constantly evolving and faces many challenges in validation and exploitation. For better use of these methods, the consortium will pursue the objective of scalability and representativity of results in the design process through appropriate Machine Learning surrogates, benefiting from High Performance Computing.The DIDEAROT project aims at bringing a digital centrepiece approach that could integrate the move to more digital designs in the aircraft industry. It will cover the robust optimization of composite structures focused on digital predictions of two key aspects in its lifetime: • Manufacturing: predicting distortions, stress build-up and assembly challenges for ever-more integrated industrial scale composite parts • Dynamic loads and impact: predicting damage and effects from loads occurring at high speed or repeated loads over time that can lead to critical certification conditions.While both aspects have been partially addressed by the research community, the challenge we tackle here is to integrate them together in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EUROPEAN GREEN CITIES' (1994-1998).

assistant: **Concept**

As a part of large development plans for new-built or retrofit in 11 European Cities, which deal with a total number of up to 30000 dwellings it is proposed to realise local demonstration projects with a total of 645 solar low energy dwellings in DK, FR, ES, IT, UK, BE and AT together with public buildings in FI and GR.In the European Green Cities it is the intention to introduce an integrated sustainable global solar low energy design using best available technologies in new build and retrofit building projects based on energy and environmental assessment together with a total energy and total economy approach, e.g. using new energy saving measures as the background for creating a realistic market for sustainable and energy efficient building. To ensure that the most cost effective solutions are selected, early price calculations will be performed in co-operation with contractors for all projects.The innovative sustainable building approach includes :- introduction of user or humidity controlled reduced ventilation rates of up to 50% of normal standard will be investigated based on improved ventilation design and building materials without unwanted emissions.- integrated solar heating design with the highest possible contribution in the heating season and avoidance of cooling in summer, PV solar energy for ventilation and optimised energy supply systems with the help of Energy Management System Control.- a global sustainable low energy design with 40-60% saving on energy for heating and DHW, avoidance of peak loads, and a 30% saving on electricity use together with a 30-40% saving on water use and at least a 50% solar DHW contribution.The project will be made in two phases, the first phase (Thermie 1996) : start up activities, investigations and design work will be com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'CREATING AND MANAGING A PIPELINE OF H2020 PROJECTS FOR THE INNOVATION FUND ON CCUS'.

assistant: **Innovation**

Carbon capture, use and storage (CCUS) has been recently recognised as a key technology to reduce carbon emissions, especially in hard-to-abate sectors, and significantly contribute to EU carbon neutrality targets for 2030 and 2050. Accelerating the upscaling and subsequent market introduction of CCUS research results and technologies is becoming thus increasingly urgent. The Horizon 2020 Programme (H2020) has contributed to the development of innovative technologies, including CCUS. The Innovation Fund Programme (IF) on the other hand, focuses on commercial demonstration of innovative low-carbon technologies. The transition from mature H2020 projects to the IF is a logical pipeline along the TRL line. Synergies between these and other EU funding programmes can contribute substantially to overcome the hurdles and de-risk large scale investments in first-of-a-kind CCUS flagship projects, but still much remains to be done in accelerating go-to-market strategies for publicly funded innovations. LEADS aims at bridging the gap from research to deployment for CCUS projects in Europe by building an innovation pipeline of promising H2020/HEU projects and supporting project owners to overcome the main bottlenecks and reach final investment decision. Building on their outstanding experience in innovation and EU programmes, as well as leveraging on their strong EU networks, LEADS partners will implement a well-designed methodology and set of measures to assess and select the most promising H2020 projects, coach them and enable them to apply to IF. LEADS methodology will be tested with six H2020 CCUS project cases. A set of reusable IF tools will be created and made available to CCUS stakeholders. Synergy mechanisms between H2020 and IF will be also created by aligning the CCUS up-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identifying the immune and microbial network controlling the IL-22 – IL-22bp axis to open the doors for targeted therapies' (2007-2013).

assistant: **Innovation**

Chronic mucosal inflammation and tissue damage predisposes patients to the development of colorectal cancer. One hypothesis is that the same factors important for wound healing, if left unchecked, also promote tumorigenesis. Tight control by a sensor of tissue damage should induce these factors to promote tissue repair, while limiting their activity to prevent development of cancer.IL-22, a prototypical tissue repair factor, plays an important role in a wide variety of intestinal disease including infection, wound healing, colitis, and cancer. Indeed, IL-22 has protective and detrimental effects dependent on the milieu and disease suggesting that proper regulation is required. IL-22 expression is directly regulated, additionally a soluble IL-22 receptor (IL-22 binding protein; IL-22bp), can bind and neutralize IL-22. We reported recently that sensing of intestinal tissue damage and components of the microbiota via the NLRP3 or NLRP6 inflammasomes led to a down regulation of IL-22bp, thereby increasing bioavailability of IL-22. IL-22, which is induced during intestinal tissue damage, exerted protective properties during the peak of damage, but promoted tumor development if not controlled by IL-22bp during the recovery phase.Accordingly a spatial and temporal regulation of IL-22 is crucial. Hence, global administration or blockade of IL-22 is unlikely to be therapeutically beneficial. We are using several newly generated conditional knock-out (cCasp1-/-, cIL-18R-/-, cIL-18-/-, cIL-22R1-/-), knock-in (IL-22 BFP), and gnotobiotic mice, aiming to analyze the cellular and microbial network regulating the IL-22 – IL-22bp axis at a resolution previously unfeasible. Our results will provide novel insights into the network between microflora, epithelium, and immune system regulat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Infrastructure Funding in the Life Sciences' under Seventh Framework.

assistant: **Concept**

It has become increasingly obvious that concepts and strategies for research infrastructure (RI) funding should be harmonised and coordinated within the EU. ESFRI has determined requirements for European RI funding and has presented a roadmap. Growing attention is paid to life sciences that rely on RIs of a less centralised, but more networked dimension. There is a clear need for action in the interdisciplinary area between physics, chemistry, biology and medical sciences as cutting edge instrumentation becomes increasingly expensive and, yet, indispensable for world-class research. However, promotion of research policies, apart from the ESFRI projects, has been restricted so far to national efforts without managing these actions with a European view. Funding and research organisations can not afford to remain at the national stage with world-wide competition for the best scientists and the most promising projects. Frontier research is international since long and funding organisations have to follow scientists to the European level. ERA-Instruments aims at initiating coordination and a sustainable network of ministries, charities, funding agencies and research councils active in funding of life science RI. This European platform of relevant stake-holders will set up comprehensive tools for adequate treatment of instrumentation related topics enabling conclusions for research policies on both a national and European level. The ERA-NET will focus on bioanalytical instrumentation (incl. post-genomic high-throughput techniques) such as NMR, mass spectrometry, microscopy, microarray platforms etc. These mid-size equipments have become an essential and strategic strength for European countries. The ERA-NET can build on the broad experience with RI funding of its partners. Co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mobilisation and transformation of personal educational knowledge for teaching: An ethnographic account on teacher knowledge' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

How do teachers rely on their educational knowledge in order to teach? An experienced teacher knows how to manage even challenging classroom situations, and performs skilfully because educational knowledge corresponds with knowing, a practical mode of knowledge that enables comprehension of a situation and affiliated situated action. Research to date predominantly attends to educational knowledge by addressing singular elements of teaching. The project PEEK addresses educational knowledge in empirical analysis from an ethnographic micro-level perspective and attends to personal orientation patterns of teachers that support transfer between educational knowledge and teaching.PEEK examines orientation patterns in which teachers frame their practice. Examination is informed by two conceptual frameworks: (1) Post-critical epistemology highlights that knowledge is used in distance to teaching to comprehend events, while knowing is used when a teacher is involved in teaching and manages these events. (2) Post-structuralist epistemology highlights transformations of knowing and knowledge that take place in technologies of the self. Both perspectives enable theoretical sensitivity for fieldwork.Ethnographic fieldwork incorporates a multi-sited approach: (1) Videographies of classroom interaction document knowing in classroom interaction. (2) Narrative interviews with teachers document reflective knowledge in which teachers condense and detail lived experiences. (3) Stimulated recalls offer ex post rationalisation of actions. (4) Video diaries provide stories of formation that reflect technologies of the self.Data analysis employs Documentary Method strategies and will result in an account on dimensions and characteristics of personal educational knowledge and how it is mobilise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Stabilization of blood coagulation factor XIIIA in blood plasma: identification of the binding domain(s) involved in the binding with FXIII-A on FXIII-B' (BI-FXIII-B) targeting Sixth Framework.

assistant: **Abstract**

Blood coagulation factor XIII (FXIII) is a heterotetramer consisting of two potentially active A subunits and two protective/inhibitory B subunits. Activated form of the zymogen is a transglutaminase, which forms isopeptide crosslinks between two polypepti de chains. Main physiological function of FXIII is to stabilize fibrin by crosslinking its chains and to protect fibrin from the powerful fibrinolytic machinery. Inherited deficiency of FXIII result in severe bleeding tendency. During the the activation of plasma FXIII first thrombin cleaves the activation peptide of the N-terminal of FXIII-A, then if Ca2+ is present, the B subunits dissociate from the A subunits and the active-site cysteine becomes available. Synthesis site for FXIII-A is in the components of monocyte/macrophage system and in the megakaryocytes. FXIII-B is synthesized in the liver. The only known biological function of FXIII-B is the binding of FXIII-A. FXIII-B has a typical domain structure, it is composed of so-called Sushi domains. Prote ins containing Sushi domains are involved in protein-protein binding, like the different components of the complement system. Binding of the two subunits of FXIII is important to maintain the stability of FXIII-A in blood plasma environment. Without FXIII-B, FXIII-A is unstable in the blood plasma. Hardly anything is known about the details of the binding of the two subunits. The resistance and stability of the fibrin clot is a central issue for the clot lysis therapies. Therefore, the ability to influence FXIII activity can be very beneficial. Fine tuning of the level of circulating FXIII-A by specific blocking peptides or monoclonal antibodies might result in more lysable fibrin clot which can be of a great importance in the treatment of thrombosis. The go al of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Tertiary heating systems using agro, forest and wood residues' in the context of a Sixth Framework call.

assistant: **Objectives**

The project is focused on the demonstration of two innovative and sustainable medium size (60 kW, 100 kW) European heating systems [combustion or co-combustion], for domestic and tertiary buildings, using as fuel medium-low quality wastes from agro/forest/wood production.The main objective of the project is to demonstrate the overall performance for two European heating systems with Mediterranean biomass, able to diversify the raw material (energy supply), reduce agro/forest/wood wastes problems and promote the use of renewable thermal energy in European countries. Each heating system is based on a sustainable and replicable approach. Raw material selected is a broad list and mix of fuels, which will allow using the most economical fuel of the market, and in addition it will improve the availability, security on supply, and opportunities to demonstrate that heating by means of biomass is possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cellular and extra-cellular pathways for sap flow: their anatomy and physiological significance' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Better understanding of plant-water relations is essential for appropriate management of forest and agricultural ecosystems in the face of global climate change. In spite of water's importance, there are surprising gaps in our knowledge of how water moves in trees. Moreover, the variation in wood tissue design of different taxa and habitats is enormous.This research will further our knowledge of wood structure and water-transport physiology in stems of woody plants, showing the actual anatomical pathways through which water moves.New information has cast doubt on the old paradigm that water ascends directly from one vessel to another; this view ignores the contribution of other cells and structures and that water must move radially in spite of no known apoplastic pathways in the radial direction, that ¼ of all vessels are gas-filled (rather than water saturated), and that vessels form networks some of which are interconnected, and others which are separated.Both the microcasting method (production of casts of the wood voids) and confocal microscopy allow three-dimensional visualization of cell structure, vessel networks, and the spaces between cells (features not or little seen before).These techniques will be combined with ecophysiological experiments on sap flow, stain movement, and vulnerability to embolism to help develop a new understanding of water transport. The work will be done in plants with contrasting ecological and wood structural patterns, and in taxa with wide geographic distribution, to further our abilities to infer function.This combination of modern techniques from the fields of anatomy and ecophysiology will help elucidate the structure, the functional significance, and the ecological adaptation of different patterns of hydraulic architecture of wood