RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bacterial Ghost Cancer Immunotherapy - A new standard in tumour therapy based on the bacterial ghost platform technology' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

MMalignant diseases represent a major health problem in all parts of the world and their incidence, according to the WHO/IARC World Cancer Report 2014, will increase by 57% worldwide in the next 20 years. Standard treatment strategies forcancer including surgery, chemotherapy and targeted molecular therapy still do not guarantee complete elimination of thedisease. In addition, cancer cells exhibited high capability to escape from immunosurveillance after applied treatment whichwas confirmed with frequently occurred relapse of disease.BIRD-C have developed Bacterial Ghost Cancer Immunotherapy (BGCI) - a novel personalised medicine approach towardsvaccination against tumours. BIRD-C’s therapeutic cancer vaccines are based on personalised dendritic cells-based cancerimmunotherapy that targets the tumour microenvironment using Bacterial Ghosts (BGs), the proprietary platform technologyof BIRD-C. The tumour therapy strategy is to (re)stimulate the patient immune system to revert the tumour evasion and buildstrong humoral and cellular immune responses against patient-specific tumour antigens. Obtained results show that BGCIcan generate effective response to tumours and indicate novel prospective methods for cellular cancer immunotherapy. Thisapproach has been tested in a form of advanced personalised cancer therapy and has improved the survival of patients withsolid tumours.During the project, BIRD-C will develop the manufacturing procedure and commercial scale-up strategy and also conduct amulti-centre trial with patients affected by various forms of cancer at different stages of progression to determine thetolerability and effectiveness of the treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sorting of Self' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

During inflammation and infection, we are simultaneously confronted with both self and non-self in form of dying cells and microbes, respectively. Mechanisms that facilitate the non-immunogenic clearance of self-antigens derived from apoptotic and necrotic cells and that, in parallel, allow the initiation of an immune response against invading pathogens are incompletely understood. Recent data from our laboratory show that the immune system actively sorts apoptotic cells (ACs) and bacteria into distinct subspecies of macrophages and dendritic cells thereby enabling a segregated processing of self and non-self as well as a differential immune response against these two entities. Incorrect sorting and aberrant uptake of AC-derived self-antigens by pro-inflammatory and antigen-presenting dendritic cells, however, results in the break of self-tolerance and autoimmunity. Due to technical limitations, the identification and fate-mapping of specific phagocyte subsets that mediate the simultaneous clearance of dying cells and pathogens in vivo has remained largely elusive. We thus plan to develop novel tools that are based on cutting-edge technologies to comprehensively elucidate the sorting of dying cells and pathogens under inflammatory conditions in vivo.  We plan to generate TAT-Cre transgenic mice and bacteria that will be used in conjunction with R26-eYFP reporter animals to permanently track phagocytes after ingestion of endogenously accumulated dying cells and pathogens, respectively. These approaches will enable us to characterize the involved phagocytes, study molecular mechanisms underlying the differential processing of self and non-self and follow the phagocyte’s migratory behaviour and its subsequent differentiation. The obtained data will not only provide insight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bio-inspired Molecular Optoelectronics', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The BIMORE network focuses on research and development of novel nanoscale molecular opto-electronic devices for storage and processing of information. The network will take advantage of bio-inspired approaches such as photosynthetic charge and energy transfer. The goal of the initiative is to integrate interdisciplinary expertise including organic- and biochemical synthesis, spectroscopic, structural and electrical characterization of molecules to build and characterize devices in order to shape future information technologies.The overall objective of the network is to exploit structural and unique photophysical properties of molecules, nanoscale structures and biological systems for development of efficient, nanosized electronic devices. Within the scope o f the initiative are energy or charge transport investigations through single molecules or small ensembles of molecules and proteins, which can either be switched by light, be redox active, or undergo a field induced conformational change. The ground and excited states of the molecules and proteins and the involved charge transfer processes will be in depth characterized in order to gain full understanding of the investigated systems.This information is key to understanding the performance of the molecules and proteins integrated into devices and to optimise device performance. Our consortium consists of a global player with long standing European research tradition in the field of information technology, five universities and two national research institutes from eight different countries, out of which two are associated states. The network has a strong focus on interdisciplinary training in this novel field, thus closing an existing educational gap in the European Research Area. The development of complementary ski
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pollution of air in the extended region of Athens: Space-based Nitrogen Dioxide (NO2) observations and their comparison with remote and ground–based measurements and modeling simulations' to be submitted under Seventh Framework.

assistant: **Abstract**

Nitrogen Dioxide (NO2) is one of the most important tropospheric pollutants leading to poor air quality and inducing climate changes. Public exposure to NO2 at urban environments is of great health concern as it is known to cause human respiratory problems. NO2 is one of the main precursors of the photochemical smog; it contributes to the acidification of the atmosphere, control the oxidation capacity of the atmosphere and affect locally its radiative forcing. In order to access the significance of these issues, a deep understanding of all relevant, physical and chemical processes, that control the atmosphere, is required. To this end, one of the most important steps towards filling the gap of knowledge on NOx relevant processes has been made recently, via space-based observations of the NO2 vertical column densities (VCD). “PARTHENO2N” focuses on the investigation of the abundances and the seasonal changes of the NO2 columns retrieved over the region of Athens and its surroundings from four different satellite instruments (GOME, SCIAMACHY, GOME-2 and OMI). In order to gain confidence in satellite observations, it is important to investigate, both qualitatively and quantitatively, their representativeness for different geo-locations. “PARTHENO2N” will provide, for the first time, a high quality intercomparison of the satellite data with various ground based, in situ and remote sensing, observations performed by: i) a novel multi axis differential optical absorption spectroscopy system (MaxDOAS) measuring both the vertical columns and profiles of NO2 ii) a Brewer-MK4 spectrometer used to retrieve column densities of NO2 and iii) in situ chemiluminescence analysers recording the nitrogen oxides mixing ratios. Lastly the validated satellite observations are going to be com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Evolution Problem in General Relativity' in the context of a Horizon 2020 call.

assistant: **Objectives**

General relativity has been introduced by A. Einstein in 1915. It is a major theory of modern physics and at the same time has led to fascinating mathematical problems. The present proposal focusses on two aspects of the evolution problem for the Einstein equations which has been initiated by the pioneering work of Y. Choquet-Bruhat in 1952.The Einstein equations form a nonlinear system of partial differential equations of hyperbolic type whose complexity raises significant challenges to its mathematical analysis. The goal of this project is to strengthen our understanding of two important themes concerning the evolution problem in general relativity. On the one hand, the control of low regularity solutions of the Einstein equations, a topic which is intimately linked with the celebrated cosmic censorship conjectures of R. Penrose, a major open problem in the field. On the other hand, the question of the stability of particular solutions of the Einstein equations in the wake of the groundbreaking proof of the stability of the Minkowski space-time due to D. Christodoulou and S. Klainerman. These directions are extremely active and have recently led to impressive results. More specifically, this project proposes to consider the following two work packages-Going beyond the bounded L2 curvature theorem. This result has been recently obtained by the PI in collaboration with S. Klainerman and I. Rodnianski and is the sharpest result in so far as low regularity solutions of the Einstein equations are concerned. Yet, the fundamental quest towards a scale invariant well-posedness criterion for the Einstein equations remains wide open.-The black hole stability problem. This problem concerns the stability of the Kerr metrics which form a 2-parameter family of solutions to  the Ein
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Co-ordination action on Indoor Air Quality and Health Effects' (ENVIE) targeting Sixth Framework.

assistant: **Abstract**

Modern European citizens spend in excess of 90 % of their time in indoor environments. Up to now national and European air quality policies have devoted most of their efforts towards the limitation of outdoor environmental concentrations for some specific pollutants. Indoor exposures to air pollution must certainly be given a better attention in policy making in such a way 1) to better understand and assess the contribution of indoor spaces to environmental diseases 2)to set up coherent policies as regards the reduction of exposures. It is therefore the objective of this project to increase the understanding of health impacts of indoor air quality. It will especially focus on the assessment of policy relevance of research into the health effects of isolated agents and mixtures, and will consider the implications for thresholds and safety margins for the general population and for people at work. It will address in particular how indoor air quality contributes to the observed rise in asthma and respiratory allergy as well as in other acute and chronic health impacts. To respond to the objectives, EnVIE has identified three major and complementary issues: Exposure, Health effects, Spaces characterisation and sources. Since the aim of EnVie is to aggregate building blocks, interfacing sciences and policy making, EnVIE will specifically consider the issue of integration and policy interface. It will also give a large attention to the dissemination in particular through the organisation of the EnVIE annual conferences and reports. EnVie is designed for a three years duration. It is based on a core group of participants from The European collaborative action urban air, indoor environment and human exposure. The consortium has 19 participants from 15 different countries, inclu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Worldwide unique automated mixing and dosing technology for precise dosed and homogenous mixed drilling fluids for horizontal directional drilling with AI-based soil type and wear detection' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Horizontal Directional Drilling (HDD) is used whenever trenchless methods are required - to lay cables under built-up or protected areas, or to minimise infrastructure disruption. HDD is thus one of the most important tools for expanding broadband and energy infrastructure. The EU's Digital Agenda should provide all EU citizens access to at least 30Mbit/s Internet by 2020.However, these targets will not be met by 2020, partly because capacities of civil engineering companies are insufficient. Despite a strong order situation, they are unable to increase capacities due to a shortage of skilled workers. For the execution of HDDs, experienced specialists are required to mix the drilling fluid essential for the drilling according to feeling. If they make mistakes, the equipment is not properly cooled, lubricated, and the drilling channel is not stabilized, causing damages of up to 45.000€.As award-winning H&E Bohrtechnik GmbH, we are Germany's only full-service provider for HDD, market leader and one of the few in this industry to develop our own innovations for industry-specific problems. To solve the problem of skills shortage, we developed Terra Smart HDD, which was named Craft Project of the Year in 2018. The unit allows to completely automate the process, which was previously dependent on experienced skilled workers, using AI-based soil type and wear detection, so that not only less experienced personnel can be hired for monitoring, but the risk of errors is also reduced from 35% to 5%. This results in a faster, safer and more cost-effective process and will enable civil engineering companies to increase capacities and to boost digitisation and energy network expansion.With Tracto-Technik and Ricona/Ditch Witch as distributors, we are thus addressing all civil engineer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multidisciplinary European Joint Doctorate in the Design and Development of Glyco Drugs' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The PhD4GlycoDrug consortium has a main goal to offer a European Joint Doctorate educational training network in Glyco-Drug Discovery and Development. The network combines 6 academic partners with long tradition in PhD training and accredited doctoral studies in Organic Chemistry, Medicinal Chemistry, Structural Biology and Pharmacology/Pharmacy. Non-academic partners, 5 SMEs and a research institute also constitute the consortium to offer intersectoral exposure and quality training in transferable skills to entrepreneurial ESRs.So far, only a handful of registered drugs originate from glycoscience area. To pursue an innovative research project in such a timely scientific field of great interest for pharmaceutical industry, a specific set of competences is needed. Our network will focus on delivering expert researchers highly attractive for employment by the European Pharma-industry. To achieve the above objectives the main tasks of PhD4GlycoDrug are:-to recruit and train 12 ESRs in a joint programme of cutting-edge training-by-research in glycoscience with high quality supervision, transferable skills training, and workshops/summer schools,-to start and pursue innovative research projects on specific macromolecular targets that bind and/or modify carbohydrate ligands involving all steps of early drug discovery from target identification and validation, through modern drug design and specific glyco-chemistry, to hit discovery and hit-to-lead development focusing on physico-chemical and ADMET properties,-to build a solid foundation for long-term European excellence in the glyco-drug discovery,-to create a common core standard for a glycodrug curriculum in the Institutions involved, which could potentially become the seed of a common European standard on the subject, and-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Avatar based Conferencing in Virtual Worlds for Business Purposes' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

In the age of a global economy, intense and efficient communication within companies or between different companies is essential in order to compete successfully in the market. Recent investigations have shown that the intensity of communication correlates directly with the geographical distance between the communicating parties. Here exists an enormous potential for intensifying collaboration between project partners and thus for improving the efficiency and effectiveness of the work itself. Conferences held online, offering all the conveniences of a real conference, help to save time and costs. Effective teamwork, bringing together the expertise of specialists from all places of the world, is crucial for the success of each project. Effects of synergies can be made use of and projects can be realised in much shorter time. This may contribute to shorter innovation cycles. AVATAR-Conference aims to develop a toolkit for the set-up and administration of virtual online conferences in which users are represented as avatars, i.e. as animated 3D-figures. The AVATAR_Conference system will be designed as a scalable, modular application, offering a large number of supportive functions, like multimedia multi-user real-time communication, speech and voice recognition facilities, online translation services, user representation through 3D-avatars within virtual worlds, multi-user 3D-manipulation and whiteboard, application sharing facilities and clients on PC and Interactive-TV.The AVATAR-Conference system provides the means for spontaneous, intuitive and intense communication between project partners. The system will especially be characterised by its high usability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Optimisation of safe food processing methods based on accurate characterisation of bacterial lag time using analysis of variance techniques'.

assistant: **Objectives**

This project aims to develop and validate a novel quantitative method, based on Analysis of Variance techniques, to give an improved prediction of bacterial lag time and growth in food. This would allow the optimisation of food processing methods, to ensure microbiological safety and quality. The distribution of the lag times of individual cells/spores will be measured by microscopic (automated image analysis) and turbid metric methods and analysed by stochastic mathematical models. The obtained distribution will be used to optimise earlier food process and treatment, and to predict the bacterial responses to the subsequent food environment accurately. The proposal addresses problems of variation of the lag time of individual cells that are not addressed by current predictive microbiology.