RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Co-operative agreements in agriculture as an instrument to improve the economic and ecological efficiency of the European Union water policy'.

assistant: **Objectives**

The motive for this project is the need to improve the economic efficiency of water use and the effectiveness of provisions concerning the protection of ecosystems with special regard to the impact of agriculture. As environmental data show, many water resources in the European Union are contaminated particularly by agro-chemicals. Furthermore, natural habitats have been destroyed and biodiversity is diminishing at an increasing rate as a result of intensive agricultural production. Although there are many debates on the strategies which might influence farmers` behaviour concerning a more sustainable agriculture (see e.g. EC project Analysis of additional EU Policy instruments for plant protection products , Wageningen Agricultural University, 1996), the present knowledge on the economical and ecological efficiency of individual policy instruments is limited. The objective of this research project is to analyse the political feasibility of co-operative agreements between farmers and the water supply companies and regulatory authorities/conservation bodies as an instrument to meet environmental standards as economically efficient and ecologically effective as possible. In Germany in particular, and also to a lesser extent Austria, the Netherlands and the United Kingdom, there are many agreements which show that the compliance with environmental standards can be reached whilst minimising the costs involved. In these cases, economic efficiency can be demonstrated by comparing the costs and benefits resulting from such agreements. For example the costs saved in drinking water treatment may well exceed the costs to agriculture arising from the use of less agro-chemicals. On the other hand, in many EC member countries, this use of this instrument is presently rare. The prima
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SNORD104 gene-encoded microRNA and its role in immune homeostasis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

MicroRNAs constitute an essential, evolutionary conserved mechanism of posttranscriptional gene expression regulation and thereby affect almost all biological processes including immune functions. In a comprehensive small RNA profiling study we identified a new, Snord104-derived microRNA, miR-145561, which is highly expressed in activated mature lymphocytes. To investigate the role of this lymphocyte-predominant microRNA we generated miR-145561 knockout mice. Aging miR-145561-deficient mice present with splenomegaly and lymphadenopathy and show an increased frequency of germinal center B cells and memory CD4 T cells. In vitro, miR-145561-deficient B cells and T cells are hyper-responsive to innate and adaptive immune receptor stimulation. In addition, miR-145561-deficient T cells show a propensity to differentiate into IL-17 producing cells. These preliminary data strongly suggest that miR-145561 plays an essential role in immune homeostasis through its function as a non-redundant negative regulator of innate and adaptive immune receptor signaling in mature lymphocytes.The goal of the current research proposal is to investigate the function of miR-145561 in immune homeostasis and lymphocyte function through the following experimental strategy: I) identification, validation and functional evaluation of miR-145561 targets in lymphocytes; II) examination of adaptive immune responses to T cell-dependent and T cell-independent antigens in miR-145561-deficient and -proficient mice; III) investigation of the susceptibility of miR-145561-deficient mice to spontaneous autoimmunity and how miR-145561-definciency affects disease onset and severity in autoimmunity prone mice; and IV) to investigate the function of the human miR-145561 homolog.This project sheds light into the mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identification of Priority RESearch TOpics for SME associations in the construction sector with a focus on new technologies in the Energy, ICT and New Materials domains' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

PRESTO aims at facilitating the identification of priority research topics for small and medium sized enterprises associations (hereinafter SMEsAs) -which in fact have a better capacity of influence than SMEs alone- by establishing a close and sustainable dialogue  with ETPs.  In order to conduct the activities contemplated by the project, PRESTO will approach four crucial industrial domains which play not only a remarkable role in the European economy, but also which are SMEs intensive sectors.   Hence, PRESTO will address the construction sector and it will devote a specific focus on three construction-associated domains, namely: energy, information and communication technologies (ICT) and new materials.  The first part of the project will be oriented towards the identification of both relevant SMEsAs as well as ETPs willing to collaborate with PRESTO. The goal will be to compose a core group -SMEsAs and ETPs- with which a close cooperation relationship will be established.  Afterwards PRESTO will evaluate the research needs of SMEsAs in the construction sector as well as the technological offers where those needs can be better accommodated. The latter point will be articulated with a close dialogue with ETPs representatives.  A further aim of the project will be to bring SMEsAs and ETPs a step closer and to favour the rapprochement of links of collaboration among them. PRESTO will produce an implementation strategy in order to appropriate conduct the cooperation relation between both parties. The strategy will have as one of its focal points the creation of SMEsAs Working Groups (WG) on ETPs. The main objective pursued by the establishment of such WGs will be to increase their leverage of SMEsAs and, hence, to gain influence in the decision-making organs of ETPs towa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'ALCUE health and quality of life platform'.

assistant: **Concept**

Based upon the Rio de Janeiro summit, and the need of a stronger cooperation between the 2 continents in the area of health, it was decided to launch a Platform on health with EU and LAC partners to help consolidate regional education and research capac ities, to innovate technologies and implement, wherever required better standardisation in health technologies and methodologies. After Bangkok 2000 (World Conference on Health Research) it was clear that Health Research Systems (either national, regional or global) should be based upon shared values and principles taking into account technological innovation diagnosis of emerging/neglected diseases; the results of these workshops will feed back the planning and priorities of the network a major delivera ble of this SSA. The main expected results are related to research and policy: a) establishment of the Platform on Health within the 6th Framework Programme objectives b)a system of informative data mainly related to Public Health Policies, new tools for i mproving quality and equity in Primary safe water and sanitation and poverty-related neglected and emerging communicable diseases. c)networking with other stakeholders d)dissemination of health information through ALCUEHEALTH website e)implementation of n ew RD projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'UNRAVELING THE EFFECTS OF SURFACE PROPERTIES ON FUNDAMENTAL MECHANISMS IN BOILING HEAT TRANSFER' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project aims to gain a new understanding on the effects of the surface properties on fundamental mechanisms in boiling heat transfer. The insight gained will provide guidelines for designing smart surfaces for more efficient and safer thermal applications. The approach consists in tackling the problem with the most advanced experimental diagnostic and sophisticated numerical simulations. The researcher demonstrates to have a clear foundation to successfully develop the project because of his solid background in two-phase heat transfer, his proficiency in measurement techniques, his strong expertise in nanotechnology and his very good computational skills. MIT and UoB are outfitted respectively with unique and ad-hoc experimental and numerical capabilities to achieve the objectives of the proposal. The fellowship will boost the researcher’s expertise towards a position of excellence by enhancing his experimental skills with cutting-edge techniques and diversifying his profile with numerical techniques and transferable skills valuable for his career prospects. The fellowship will establish a new network between the organizations and increase the internationalization of the researcher aiming to become an independent and mature research leader. The project fits into different pillars of Horizon 2020: 1) Societal Challenges: Secure, clean, and efficient energy. It aims to provide new knowledge to increase the efficiency and enhance the safety of different energy processes (important for reducing the CO2 emissions); 2) Excellence Science: Future and Emerging Technologies. It aims to identify the surface effects on heat transfer mechanisms, which could be exploited for developing new energy technologies; 3) Industrial Leadership: Nanotechnologies, Advanced Materials, Advan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'INCLISAFE BLACKBOX' (2014-2020).

assistant: **Innovation**

The purpose of the present proposal is the launching to the market of an innovative product called INCLISAFE BLACKBOX, which will be oriented to protection and safety of drivers of vehicles (firefighting trucks, tractors, logistics vehicles). Currently, there are lots of truck and tractor accidents (rollovers) due to the lack of stability of the vehicle in dynamic mode.  At present, apart from DTA first generation of INCLISAFE products (IS1 and VEXT), there are not solutions that measure the stability of a truck in a dynamic mode. Current commercial products are basically inclinometers (that measures potential rollovers but only have reliability in static mode because it doesn´t take into account parameters such as momentum of inertia that has a great impact in dynamic mode) or accelerometers (that don´t take into account parameters such as angular velocity or momentum of inertia that impact in vehicle stability). INCLISAFE BLACKBOX will allow preventive detection, tilt warning and also will have data logging capabilities, making INCLISAFE BLACKBOX an EDR (Event Data Recorder), which will have superior characteristic that currently INCLISAFE line of products (IS1 and VEXT). INCLISAFE BLACKBOX has also advantages such as cost reductions (less accident mean less repairing’s). This proposal is key to DTA, as safe and smart solutions is the Core Business for the Company, after successfully developed a product with prove the main algorithms but have a lot of features missing and requested by the customers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Small farms, small food businesses and sustainable food security'.

assistant: **Concept**

SALSA will assess the role of small farms and small food businesses in delivering a sustainable and secure supply of affordable, nutritious and culturally adequate food. SALSA will identify the mechanisms which, at different scales, can strengthen the role of small farms in food systems and thereby support sustainable food and nutrition security (FNS). By considering a gradient of 30 reference regions in Europe and in Africa, we will obtain a differentiated understanding of the role of small farms and small food businesses in very differently structured food systems and situations. SALSA will elaborate and implement a transdisciplinary, multi-scale approach that builds on and connects relevant theoretical and analytical frameworks within a food systems approach, and that uses qualitative, consultative and quantitative methods. We will also test a new combination of data-based methods and tools (including satellite technologies) for rigorously assessing in quantitative terms the interrelationships between small farms, other small food businesses and FNS, paying particular attention to limiting and enabling factors. SALSA will use participatory methods, at regional level, and establish a more global Community of Practice and multi-stakeholder learning platform, based on FAO’s TECA online communication and learning platform.The SALSA consortium, and the joint learning and close cooperation, have both been designed with the EU - Africa dialogue in mind. Responding to the call we will unravel the complex interrelationships between small farms, small food businesses and FNS, and unfold the role played by small farms in (a) the balance between the different dimensions of sustainability, (b) maintaining more diverse production systems, (c) supporting the urban/rural balance in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding the individual host response against Hepatitis D Virus to develop a personalized approach for the management of hepatitis D' under Horizon Europe.

assistant: **Concept**

Hepatitis D is by far the most severe form of chronic viral hepatitis frequently leading to liver failure, hepatocellular carcinoma and death. Hepatitis D is caused by coinfection of hepatitis B patients with the hepatitis D virus (HDV). Up to 20 Million individuals are infected with HDV worldwide including about 250.000 patients in the European Union. There is very limited knowledge on disease pathophysiology and host-virus interactions explaining the large interindividual variability in the course of hepatitis D. It is in particular unknown why 20-50% are spontaneously able to control HDV replication, why the majority but not all patients progress to advanced stages of liver disease and why only some patients show off-treatment responses to antiviral treatment with either pegylated interferon alpha or the novel HBV/HDV entry inhibitor bulevirtide. As HDV is an orphan disease, no multicenter cohorts of HDV infected patients are available with appropriate biobanking. There is also no reliable animal model available allowing to study host responses. Thus, there is an urgent clinical, social and economic need to better understand individual factors determining the outcome of infection and to identify subjects benefitting from currently available treatments.  Hepatitis D is a protype infection which could hugely benefit from a novel individualized infectious medicine approach. We here aim to perform an unbiased screening of a large multicenter cohort of well-defined HDV-infected patients followed by mechanistic studies to determine the functional role of distinct molecules. Identified specific parameters could have an immediate impact on the personalized surveillance strategies and antiviral treatment approaches. D-SOLVE aims to reduce disease burden, improve patient?s qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Active role of skeletal muscle extracellular matrix in muscular dystrophies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Most of the muscular dystrophies (MDs) are due to defects the trans-membrane protein complex called Dystro-GlycanComplex, which is a structural and functional bridge between myofiber contractile apparatus and extracellular matrix(ECM).MD research is focused upon the cellular mechanisms of the pathology and there is a lack of information about howECM molecules can affect MDs, although alteration in ECM composition is acknowledged since fibrosis is an important badoutcome in the patients.Our hypothesis is that alterations in dystrophic muscle ECM directly account for mechanisms whichnegatively affect skeletal muscle homeostasis.The goal of the project is to identify alterations in ECM compromised bymuscular dystrophy and to investigate their effects on cell behavior.Mdx mouse (model for Duchenne Muscular Dystrophy)and Sarcoglycan-β-null mouse (model for Limb Girdle Muscular Dystrophy 2E) will be used.To obtain the ECMs we will takeadvantage of decellularization approach that removes the cellular components while maintaining the molecular and structuralfeatures as closer as possible to the native ECM.In tissue engineering the use of ECM biomaterials demonstrated that ECMplays a fundamental, active role in tissue remodeling by growth factors release and ECM degradation productaction.Molecular alterations in the ECM composition will be investigated by proteomics that assures an accurate andexhaustive characterization.ECM will be used as 3D environment to study its functions in the behavior of primary cellsinvolved in the pathology: myogenic stem cells, endothelial cells, fibro-adipogenic precursors and macrophages.Discoveringhow alterations in dystrophic muscle ECM affect myogenesis, angiogenesis, fibrosis and inflammatory response will be ofparamount importance for a better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of the MADS-box family in plant architecture' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This proposal aims to identify functions of a regulatory gene family which control plant development and to use those functions to generate crop plants with improved characteristics. Biotechnological modification of plant features such as flowering time, leaf area, height, growth habit, reproduction etc. requires the isolation of new genes and the determination of their roles in controlling these processes. Rather than addressing this need by concentrating on specific developmental stages, we will identify and characterise the functions of a gene family with the potential to influence all aspects of growth and development - the MADS-box genes (MBGs). MBGs are regulatory transcription factors with a strong precedent for controlling plant development. They are involved in developmental decisions in all eukaryotes in which they have so far been found. Plants have more family members than either animals or yeasts and the known control functions of some of the plant genes include: floral organ identity, meristem determinacy and floral transition. The full extent of the plant gene family is unknown, but individual members are expressed at all developmental stages and in a wide variety of tissues (see proposal Figure 1). MBGs share certain structural and functional properties which make them ideal candidates for biotechnological approaches to alter plant development. We will isolate all members of the MADS-box gene family from two model species, Antirrhinum and petunia, using both cDNA and genomic approaches to ensure saturation. The expression patterns of the genes will be determined and the gene functions will be knocked out using a fully operational and efficient PCR/transposon mutagenesis strategy, which is available for both species. The effects of single and multiple MBG