RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EUROPEAN ACCESSIBLE INFORMATION NETWORK' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

EUAIN aims to promote e-Inclusion as a core horizontal building block in the establishment of the Information Society by creating a European Accessible Information Network to bring together the different actors in the content creation and publishing industries around a common set of objectives relating to the provision of accessible information. Accessibility for print impaired people can be an increasingly integrated component of the document management and publishing process and should not be a specialised, additional service.EUAIN will take the broadest definition of content creators and will provide the support, tools and expertise to enable them to provide accessible information. This is now feasible due to recent developments at several levels. From a technical perspective, it is now possible to address key concerns of content creators and providers and coherently address issues such as: automation of document structuring, adherence to emerging standards, workflow support, digital rights management and secure distribution platforms. Similarly, emerging international and European standards provide an excellent basis for the creation of accessible information at a more fundamental level than has previously been possible. EUAIN will establish a fluent communication of experience with standardisation bodies. At a European and national level, there now exists a clear desire on the part of associations of publishers to collaborate closely with experts in order to provide truly accessible materials. However, what is still clearly needed is a focal point to bring these disparate initiatives together. The European Accessible Information Network will provide this cohesion by addressing the key areas and issues, which are of common concern to all the actors in this area. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasks'.

assistant: **Concept**

How does the brain integrate diverse sensory inputs and generate appropriate motor commands? Our cerebellum is a key region for such a sensorimotor processing, empowered by its sophisticated neural computation and constant communication with other brain regions. The well-timed cerebellar information is integrated and funneled to other brain regions through the cerebellar nuclei (CN). Yet, how CN circuitry contributes to the cerebellar control of sensorimotor processing is unclear. My recent work indicates that the CN activity serves various functions ranging from the online motor control, the amplitude amplification of cerebellar outputs to the control of motor planning. Given these advances, I am now in a unique position to decipher the properties of CN neurons and identify their specific roles in different forms of sensorimotor processing. It is my central hypothesis that depending on the specific demands of the task, CN neurons can either facilitate or suppress the activity of downstream regions with millisecond precision; and the anatomical, genetic and functional properties of CN neurons are tailored to the particular task involved. To test this hypothesis, I will 1) identify the activity patterns of different CN modules during the acquisition and execution of two sensorimotor tasks and characterize the relevant extra-cerebellar inputs to these modules; 2) identify the connectivity-transcription logic of different CN modules and link them to their task-specific outputs; and 3) examine the impacts of manipulating anatomically and/or genetically defined CN neurons on the downstream regions during different sensorimotor tasks. I will accomplish these key objectives by developing various novel electrophysiological, optogenetic, molecular and imaging techniques. My rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ERIC Forum Implementation project' to be submitted under Horizon 2020.

assistant: **Abstract**

ERIC – European Research Infrastructure Consortium – is a European legal instrument specifically created for European multi-side and multi-country owned Research Infrastructures (RI) in 2009. Since then 18 ERICs have been created in almost all different scientific domains.The European Commission (EC) had initiated an informal networking event, twice a year, where Managers of existing ERICs and scientists of future RI who want to use the ERIC instrument can discuss shared challenges and meet also national policy makers establishing a platform for exchange of solutions and best practises. With the H2020 call “INFRASUPP-01-2018-2019 Policy and international cooperation measures for research infrastructures” the EC is willing to fund a project for more formal and structural collaboration and coordination of ERICs.This project is set up by all existing ERICs and those consortia, which have at least submitted their Stage-1 application to implement the objectives of the call:•aim at strengthening coordination and networking reinforcing the informal ERIC network or its successor framework;•support the organisation of specific meetings, targeted thematic workshops focussing on shared challenges such as the development of internal procurement rules, harmonised reporting, VAT exemption practices, insurances and pensions policies and training of governance bodies representatives;•support ERICs in preparation, based on best practices;•support common communication and outreach activities and strengthening external representation of ERICs' as a stakeholder in consultations and other policy actions that could affect them.


**Keywords:** ERIC, research infrastructures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Atomically thin layers of Organic-Inorganic Perovskite Crystals – Electronic Properties and Application in Solar Cells', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

We propose to experimentally study the electronic properties of organic-inorganic perovskite crystal (OIPC) monolayers by means optical spectroscopy and charge transport measurements.In the last few months, OIPC’s have emerged as an outstanding material for inexpensive and efficient solar cells. In a series of studies, various research groups have successfully demonstrated the preparation of solar cells with 10-15% power conversion efficiency.   In addition to their remarkable performance in solar cell applications, OIPC’s can form layered structures that are held together by relatively weak VdW interactions. Thus, monolayers of OIPC’s can be readily separated and isolated by mechanical exfoliation, which enables controlled studies of their surface and interfacial properties.The overall goal of the research described in this application is to understand what makes OIPC’s such efficient materials for solar cell applications and to develop methods to further improve their performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Regeneration of semiarid plant communities: the role of el nino southern oscillation and herbivory control'.

assistant: **Objectives**

The project aims to unravel the combined effects of herbivore and rainfall variability associated to El Nino Southern Oscillation (ENSO) on the recruitment of trees ands shrubs in semiarid areas of Chile and Peru. The project will:1) Reconstruct the historic role of ENSO in recruitment and growth using tree ring analyses of key species,2) Analyse the effects of herbivore, water availability, and adult shade on seedling establishment of key tree/shrub species using controlled field experiments,3) Develop guidelines for the regeneration of degraded woodlands and the sustainable use of semiarid ecosystems based on the opportunely use of ENSO-related rainfall and grazing control. The results will be discussed with decision-makers. This could represent an innovative approach for reforestation and forestation programs, and is in line with the priorities established in the International Convention on Desertification.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ET-LCGT Telescopes: Exchange of Scientists' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A new way to investigate the Universe will be possible when the new generation of gravitational wave telescopes becomes operative. First, the advanced detectors, then the 3rd generation observatories will allow to detect the gravitational wave signal emitted in catastrophic event in the Universe. The Large-scale Cryogenic Gravitational wave Telescope (LCGT, now named KAGRA) in Japan and the Einstein gravitational-wave Telescope in Europe will adopt new technologies (in cryogenics, mechanics and optics) that necessitate an intense R&D activity and a fully collaborative exchange of know-how between Europe and Japan. The aim of the ELiTES project is to furnish the initial kick-off to this exchange programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Quantifying transcription factor search mechanism by three-dimensional single molecule tracking'.

assistant: **Concept**

Transcription factors (TFs) are capable to identify their target sites on DNA in a extremely efficient fashion. The observation that a simple 3D diffusion search cannot account for such efficient targeting has led  to different mechanisms to be proposed in the last decades, including compact exploration induced by facilitated diffusion (i.e. combination of 1D sliding and 3D diffusion) or by fractal-like chromatin structure. Despite the  evidence for 1D sliding of TFs on DNA and for fractal nuclear organization, it still needs to be demonstrated that these phenomena play a significant role in the TF search mechanism in a living cell. Fluorescence microscopy and in particular single molecule tracking (SMT) provides an excellent tool to investigate the kinetics of proteins in living samples. SMT has mostly been applied to in-vitro and in-membrane environments due to limitations associated to prolonged 3D tracking. In this project we plan to overcome the limitations associated to 3D SMT and to apply the developed technology to investigate the in-vivo search mechanisms of p53, an important TF, involved in the determination of the cell fate under stress conditions. We aim to quantify the role of compact exploration in p53 targeting in living cells, and by the analysis of mutated p53 how 1D sliding affects such phenomenon. Furthermore, we plan to identify the changes in the p53-DNA association and in the p53 search after induction of cell stress by DNA damage. Summarizing, the project aims to strongly improve current methods for tracking individual molecules in 3D and to advance our knowledge about the mechanisms of TF targeting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Architectures, Materials, and One-dimensional Nanowires for Photovoltaics - Research and Applications' (AMON-RA) targeting Seventh Framework.

assistant: **Abstract**

The proposed project AMON-RA (Architectures, Materials, and One-dimensional Nanowires for Photovoltaics – Research and Applications) is intended to result in a new type of solar cell, combining advanced hetero- and nano-structures with silicon photovoltaic technology. By ap-plying state-of-the-art photovoltaics design to semiconductor nanowires and nanotrees and assisted by tailor-made theoretical modeling and advanced processing, we aim to demonstrate high-efficiency multi-junction photovoltaic cells made from previously impossible materials combinations. The high degree of self-assembly and insensitivity to lattice parameters inherent in the nanowire growth process will also make it possible to produce such cell relatively cheaply and on inexpensive silicon substrates. In AMON-RA, we will also evaluate the solar cell designs on a systems level, with special attention to future industrialization and upscaling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Function of inflammatory signalling pathways in acute and chronic liver disease and liver cancer' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aim of this proposal is to examine the role of inflammatory signalling pathways in murine models of liver and biliary disease by application of conditional gene targeting using cre/loxP technology. Previous studies have provided evidence that the NF-kB pathway and its activating kinase complex – consisting of three subunits: IKK1, IKK2 and NEMO – are crucial regulators of liver physiology and pathology, but their differential, cell specific functions in the liver are currently only poorly understood. The first part of this proposal will focus on the evaluation of molecular mechanisms underlying the development of hepatocellular carcinoma in a setting of chronic hepatitis. By using a novel mouse model of spontaneous liver cancer based on conditional deletion of NEMO in hepatocytes, the functions of cytokines, specific intracellular signalling pathways, the innate and adaptive immune system and the role of hepatic stem cells in hepatitis and carcinogenesis will be examined. In the second part of this proposal, we will extend these studies by evaluating the function of NEMO/NF-kB in other hepatic cell compartments, specifically the function of NEMO in hepatic stellate cells and liver fibrosis, the endothelial function of NEMO/NF-kB in an in vivo model of hepatic ischemia-reperfusion injury and the role of the NF-kB pathway in biliary epithelial cells and inflammatory biliary diseases. Finally, in the third part of this proposal we will analyse the unknown intrahepatic role of non-canonical, IKK1-dependent signalling pathways and the function of TAK1 – a molecule at the interface between inflammatory and developmental pathways – in liver injury, fatty-liver-disease and insulin-resistance. Knowledge gained by these studies and the further understanding of the cell specif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Rural landscape hEritage and CArbon sequeSTration' to be submitted under Horizon Europe.

assistant: **Abstract**

With the ongoing climate emergency and nations’ commitments to meet net-zero carbon emissions by 2050, there is a heightened need to contrast climate change through sustainable land-use (LU) strategies. Agroforestry (AF) has existed since ancient times in European countries, and it has been recognised as one of the most beneficial rural LU systems. The RhECAST (Rural landscape hEritage and CArbon sequeSTration) project aims to develop a new interdisciplinary approach to investigate the interactions between sustainability and rural landscape heritage with particular reference to CO2 sequestration over the long term. The project will take an interdisciplinary approach that combines landscape archaeology (HLC - Historical Landscape Characterisation), computer-based modelling (MSD - Multi-Sector Dynamics) and archaeological soil geochemistry (ASG), and it will focus on one of the main European hot spots of atmospheric pollution, the Po - Venetian Plain (PVP - Italy). The main project innovation will be to develop an MSD model using HLC data to determine which would be the effect on climate change mitigation by recasting the current PVP’s industrial agriculture with historical AF. ASG will be essential to constrain the MSD model results leading to significatively more precise outcomes of past and potential future CO2 sequestration. Thus, the RhECAST project aims at modelling CO2 sequestration rate of historical AF to inform sustainable landscape management plans that will maximise climate change mitigation whilst preserving the regional cultural identity. By applying a range of innovative and interdisciplinary techniques, the project will be able to develop a model that could be potentially extended in other European regions with similar historical and environmental characte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Combining methodologies to assess water pollutant hazard and environmental risk in south Europe' under Sixth Framework.

assistant: **Concept**

The project aims to develop, improve and test a multidisciplinary approach to assess the bioavailability and ecotoxicity of several organic contaminants in sediments of water bodies and estuaries sampled in different Italian locations. Chemical and biological techniques will be adopted in order to assess the actual risk posed by sediment contamination, i.e. the sum of exposure (bioavailability chemical assessments) and effects (ecotoxicity tests with metabolic and catabolic biosensors).This will be achieved through the following sub-objectives:(a) assess reliable chemical techniques for the quantification of the actual and potential bioavailable fractions of contaminants;(b) assess the general and toxic effects of contaminants, with particular regard to their bioavailable fractions;(c) assess any synergistic and additive effects between different chemicals;(d) predict the bioremediation potential for a different number of case studies.Sediments and water samples from different contaminated Italian sites will be sampled and analysed. They will differ in terms of physico-chemical properties, contamination extent, history and presence of specific compounds. The feasibility of the innovative approach proposed here will be therefore tested on a number of different case studies. Useful information on the remediation potential will be achieved as well. Together with the coordinator the researcher has planned a three-year project to allow a reintegration in the HOST or other institutions in EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SYSTEMS-BASED VIEW OF MELANOMA PROGRESSION: TOWARDS NOVEL DIAGNOSTIC (AND THERAPEUTIC) APPLICATIONS'.

assistant: **Concept**

Worldwide figures show that there were 160,000 incidences of melanoma in 2002, whilst 39,000 died from the disease. These upward trends are worrying, as malignant melanoma is one of the most difficult cancers to treat, due to its ability to spread quickly and its resistance to standard chemotherapeutic agents. In order to counteract this trend, targeted therapies that inhibit melanoma metastasis are required. The aim of SYS-MEL is to identify and validate prognostic and predictive biomarkers for melanoma, and to model the predictive value of these biomarkers in determining the efficacy of melanoma therapies. The central objective is to bring together four European academic institutes and two SMEs to develop 3 prognostic/predictive biomarker assays for melanoma. 3 core areas of interest are epigenetics, signalling pathways in melanoma and systems biological approaches for predicting chemotherapy responses. SYS-MEL will have three main elements: 1) Epigenomic and protein expression analysis of melanoma tissue, to validate an epigenomic signature initially identified in the FP7-funded programme Target-Melanoma; 2) In silico modelling and prediction of patient responses to decarbazine DTIC using both in vitro analysis of apoptotic pathways and a novel systems biology approach, incorporating mathematical systems modelling, quantitative biochemistry and cell biology; 3) Investigating the components of the P-Rex1 pathway that are involved in driving the migration of melanoblast cells, and thus the progression of metastasis, incorporating a computational system tailored to model complex signalling pathways. This approach will enable us to identify prognostic and predictive biomarkers for melanoma, and to develop a powerful computational modeling approach to predict disease prog