RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Metal-mediated Ring-opening Polymerizations: New Monomers, Catalysts and Materials'.

assistant: **Objectives**

Polyesters represent one of the most important classes of polymeric materials, providing essential feedstocks for commodity products, medical devices and specialty polymers with tunable properties. Our current efforts focus on the development of polyesters derived from renewable resources, specifically targeting polymers with both microstructure and macrostructure control.We design catalysts that mediate the ring-opening polymerisation of cyclic esters for this purpose. By designing monomers, reactions and catalysts we can generate biodegradable and bioassimilable materials, many of which are new and may have unprecedented properties as functional materials. In all cases, we modify polymer stereoregularity to further tune the thermal properties, degradation rates and self-assembly of our materials. Specific research goals for this transitional grant are as follows:(1) Tacticity and an Expanding Monomer Scope. We will combine our expertise in the ROP of cyclic esters with our understanding of catalysis and ligand design to expand tacticity control to new monomer classes including (i) cyclic morpholinediones to afford poly(depsipeptide)s, cyclic phosphate esters to afford degradable flame retardants and β-butyrolactone derivatives to afford biodegradable thermoplastic elastomers.(2) Functional materials. We will synthesize new-to-the-world materials, with a particular focus on controlling under-exploited monomers, is essential to expanding the scope of green materials. We will develop novel hyperbranched polyesters, hydroxy-functionalized degradable materials and multi-functional materials prepared through immortal ring-opening (co)-polymerisation and olefin metathesis.(3) Catalyst design. We will design new catalysts capable of mediating these challenging reactions, with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Late Holocene climate and sea ice variability in the southwestern Labrador Sea' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

CLIMICE aims to reconstruct late Holocene changes in sea ice variability and regional sea surface temperatures (SST) in the Labrador Sea area using high-resolution sediment records. Information of past natural variability in climate is essential for refining and validating future climate change models and improving predictions. The records will contribute to a better understanding of the role of Arctic sea ice export by the Labrador Current in influencing large-scale North Atlantic thermohaline and atmospheric circulation. The study area is climatologically crucial, since sea ice, ice bergs and associated melt water entrained by the Labrador Current directly affect the mid-latitude main core of the Gulf Stream warm water transport route towards the north. The sediments will be analysed using a highly innovative biological and chemical multi-proxy approach based on 1) study of fossil diatom assemblages and diversity, focusing on ice diatoms, and diatom-inferred reconstruction models for sea surface temperatures, and 2) IP25, a recently established chemical tracer for sea ice algae. The study will further include sediment alkenone data, a well-established chemical proxy for SST, and (fossil) diatom oxygen isotope data, the latter implying an experimental approach for SST reconstruction still having many uncertainties. Paleoceanographic data from dinoflagellate and foraminifera studies of the same sediment cores will also be available. Thus, this study provides a unique possibility to compare results from IP25 and oxygen isotope analyses with well-established climate proxies from the same sediment cores. Due to the (partly) innovative and experimental character of the work, realisation of the project is only feasible by collaboration of several laboratories based in Denmar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A non-inferiority randomized trial testing an advice of modeA non-inferiority randomized trial testing an advice of moderate drinking pattern versus advice on abstention on major disease and mortality' (UNATI).

assistant: **Concept**

Europeans are the largest alcohol consumers. Policymakers and clinicians are currently perplexed on how to reduce alcohol harms in drinkers, due to contradictory guidelines: abstention is proposed as the healthiest option by many health advocates, stating that there is no safe level of alcohol intake; but most nonrandomized studies found lower all-cause mortality and other outcomes in moderate drinkers than in abstainers among subjects >50 years. However, potential biases may compromise these latter studies, particularly when effects are null or moderate. A large pragmatic randomized controlled trial (RCT) of realistic advice aimed to change behavior addressing clinical endpoints is long overdue. It will provide first-level evidence to confront the harms of one of the most widely used substances by humankind. Business issues and conflicts of interests are also at stake. We propose a 4-year non-inferiority RCT with >10,000 drinkers (men 50-70 years or women 55-70 years consuming >=3 but <40 drinks/wk). To reduce alcohol-associated harms they will be randomized in a 1:1 ratio to 2 advices: 1) abstention; 2) moderation (<=7 drinks/wk (females) and <=14 drinks/wk (males)), and avoidance of binge drinking, with preferential consumption of red wine with meals, and consumption spread out throughout the week. Moderate consumption is hypothesized to be non-inferior. No participant will be invited to increase his/her alcohol intake. The primary endpoint will be a global index of all-cause mortality, cardiovascular events, cancer, liver disease, depression, dementia, diabetes, tuberculosis or other major infection or injury. The difficulties for feasibility are significant, but more complex large behavioral trials developed by the principal investigator (PREDIMED and PREDIMED-Plus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Imaging Perfusion Restrictions from Extracellular Solid Stress' (ImPRESS) under Horizon 2020.

assistant: **Objectives**

Even the perfect cancer drug must reach its target to have an effect. The ImPRESS project main objective is to develop a novel imaging paradigm coined Restricted Perfusion Imaging (RPI) to reveal - for the first time in humans - vascular restrictions in solid cancers caused by mechanical solid stress, and use RPI to demonstrate that alleviating this force will repair the cancerous microenvironment and improve therapeutic response. Delivery of anti-cancer drugs to the tumor is critically dependent on a functional vascular bed. Developing biomarkers that can measure how mechanical forces in a solid tumor impair perfusion and promotes therapy resistance is essential for treatment of disease. The ImPRESS project is based on the following observations; (I) pre-clinical work suggests that therapies targeting the tumor microenvironment and extracellular matrix may enhance drug delivery by decompressing tumor vessels; (II) results from animal models may not be transferable because compressive forces in human tumors in vivo can be many times higher; and (III) there are no available imaging technologies for medical diagnostics of solid stress in human cancers. Using RPI, ImPRESS will conduct a comprehensive series of innovative studies in brain cancer patients to answer three key questions: (Q1) Can we image vascular restrictions in human cancers and map how the vasculature changes with tumor growth or treatment? (Q2) Can we use medical engineering to image solid stress in vivo? (Q3) Can RPI show that matrix-depleting drugs improve patient response to conventional chemo- and radiation therapy as well as new targeted therapies? The ImPRESS project holds a unique position to answer these questions by our unrivaled experience with advanced imaging of cancer patients. With successful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Social INnovation to FOster iNclusIve Cooperative, connected and Automated mobility' (SINFONICA) under Horizon Europe.

assistant: **Objectives**

SINFONICA aims to develop functional, efficient, and innovative strategies, methods and tools to engage CCAM users, providers and other stakeholders (i.e. citizens, including vulnerable users, transport operators, public administrations, service providers, researchers, vehicle and technology suppliers) to collect, understand and structure in a manageable and exploitable way their needs, desires, and concerns related to CCAM. SINFONICA will co-create final decision support tools for designers and decision makers to enhance the CCAM seamless and sustainable deployment, to be inclusive and equitable for all citizens.


**Keywords:** society, users, co-creation, accessibility, public transport, rural mobility, urban mobility, acceptability, expectations, needs, recommendations, knowledge, inclusiveness, user-centred, accessibility
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nitrification Reloaded - a Single Cell Approach' (NITRICARE) targeting Seventh Framework.

assistant: **Abstract**

Nitrification is a central component of the Earth’s biogeochemical nitrogen cycle. This process is driven by two groups of microorganisms, which oxidize ammonia via nitrite to nitrate. Their activities are of major ecological and economic importance and affect global warming, agriculture, wastewater treatment, and eutrophication. Despite the importance of nitrification for the health of our planet, there are surprisingly large gaps in our fundamental understanding of the microbiology of this process. Nitrifiers are difficult to isolate and thus most of our current knowledge stems from a few cultured model organisms that are hardly representative of the microbes driving nitrification in the environment. The overarching objective of NITRICARE is to close some of these knowledge gaps and obtain a comprehensive basic understanding of the identity, evolution, metabolism and ecological importance of those bacteria and archaea that actually catalyze nitrification in nature. For this purpose innovative single cell technologies like Raman-microspectroscopy, NanoSIMS and single cell genomics will be combined in novel ways and a Raman microfluidic device for high-throughput cell sorting will be developed. Application of these approaches will reveal the evolutionary history and metabolic versatility of uncultured ammonia oxidizing archaea and will provide important insights into their population structure. Furthermore, the proposed experiments will allow us to efficiently search for unknown nitrifiers, evaluate their ecological importance and test the hypothesis that organisms catalyzing both steps of nitrification may exist. For non-model nitrifiers we will develop a unique genetic approach to reveal the genetic basis of key metabolic features. Together, the genomic, metabolic, ec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Wide bandgap semiconductor TiO2  isotope battery'.

assistant: **Concept**

Long-life and maintenance-free energy sources for Micro-Electro-Mechanical Systems (MEMS) in extreme environments is a research challenge in the field of micro-energy worldwide. One of the most promising solutions to this challenge is the development of micro-energy batteries that utilize isotope decay energy. Although isotope batteries have significant advantages over other energy sources in terms of operating environment, usage time, and energy density, the main engineering application bottlenecks of isotope batteries currently are their low energy conversion efficiency and low power density. Current research is constrained by two major limitations: poor matching between the sources and energy conversion materials, and the lack of energy conversion materials that can efficiently promote the separation of charge carriers. Therefore, research on tritium water electrochemical isotope batteries based on ""new structures"" and ""new materials"" is an inevitable choice. This  project BetaBatt intends to use software simulation to guide experimental research methods, develop long-life and high-efficiency micro-power sources. The objective is to achieve an ECE of no less than 20%, an output power density of no less than 5 μW/cm3, and continuous power supply for no less than 10 years, thereby, eliminating obstacles for the practical engineering application of MEMS across multiple environmental conditions. This research aims to develop an efficient and clean battery for the micro-energy field in Europe. The ER will achieve abundant research experience and scientific skills from the project and the capability to launch her own research group in future.""


**Keywords:** Micro-energy,  titanium dioxide, MEMS, hydrogen isotope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Fast track development of a Zika vaccine based on measles vector'.

assistant: **Objectives**

Zika virus is an emerging mosquito-borne flavivirus. Although already isolated in 1947, to date there are no specific treatments nor any vaccines available against Zika virus disease, making it a truly neglected infectious disease. The recent rapid spread of the Zika virus in previously unaffected regions has provided strong epidemiological evidence that infection with this virus might be associated with neurological complications in adults and with an increase in severe congenital brain malformations of new-borns. Consequently, the World Health Organization has declared the recent outbreak of the Zika virus a public health emergency.The ZIKAVAX proposal has the objective to address this urgent public health issue by promoting the rapid development of a safe, effective, and affordable preventive vaccine against Zika virus infection. To achieve this goal, ZIKAVAX will use a delivery platform technology based on a measles vaccine vector with demonstrated proof of principle in humans and a preclinical track record of rapid adaptability and effectiveness for a variety of pathogens. The manufacturing process for these measles vector-based vaccines has been developed to give high yield and purity using standard equipment. In ZIKAVAX, following antigen selection and expression, immunisation studies will be conducted with the Zika vaccine candidate in mice and in a challenge model in non-human primates that will developed by the consortium. The ultimate goal of ZIKAVAX is the demonstration of safety and immunogenicity of a recombinant measles-Zika vaccine candidate in adult volunteers in a phase Ia clinical trial.ZIKAVAX is driven by a strongly committed and effective consortium of four leading European organisations highly experienced in vaccine research and development. Its p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'predictinG EaRthquakES induced by fluid injecTion' (GEoREST), addressing dissemination and exploitation.

assistant: **Impact**

Fluid injection related to underground resources has become widespread, causing numerous cases of induced seismicity. If felt, induced seismicity has a negative effect on public perception and may jeopardise wellbore stability, which has led to the cancellation of several projects. Forecasting injection-induced earthquakes is a big challenge that must be overcome to deploy geo-energies to significantly reduce CO2 emissions and thus mitigate climate change and reduce related health issues. The basic conjecture is that, while initial (micro)seisms are caused by well-known mechanisms that could be predicted, subsequent activity is caused by harder to understand and, at present, unpredictable coupled thermo-hydro-mechanical-seismic (THMS) processes, which is the reason why available models fail to forecast induced seismicity. The objective of this project is to develop a novel methodology to predict and mitigate induced seismicity. We propose an interdisciplinary approach that integrates the THMS processes that occur in the subsurface as a result of fluid injection. The methodology, based on new analytical and numerical solutions, will concentrate on (1) understanding the processes that lead to induced seismicity by model testing of specific conjectures, (2) improving and extending subsurface characterization by using industrial fluid injection operations as a long-term continuous characterization methodology, so as to reduce prediction uncertainty, and (3) using the resulting understanding and site specific knowledge to predict and mitigate induced seismicity. Project developments will be tested and verified against fluid-induced seismicity at field sites that present diverse characteristics. Arguably, the successful development of this project will provide operators with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chronology of the Norse TransAtlantic Colonies and Territories', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

For ten thousand years, the world was divided in two. Almost all human societies belonged to either the Old or the New Worlds. Amid this consummate isolation, the two worlds followed their own cultural and ecological trajectories. The loop was finally closed when the Norse arrived in the Americas in 1021 CE. However, the story of this closure ironically remains one of the most significant gaps in our knowledge of the past. This project addresses the timing, duration, geographical extent and lasting significance of this period of first contact. Using the newly developed tools of spike radiocarbon dating and ancient DNA provenancing, current understanding of the Norse transatlantic expansion will be both tested and extended. Data of unprecedented precision will cast the history of Greenland into sharp relief, allowing fresh insights to be gained on the role of conflict, climate and trade in the ultimate abandonment of the colony. Furthermore, by analysing artefacts on either side of the Atlantic, the true extent and temporality of the Norse presence in the New World will be unveiled. Drawing all the new evidence together, CONTACT will be able to trace the story of the period as it has oscillated down the centuries between fact and fiction. In so doing, it will establish a framework for reanalysing the earliest connections between the Old and the New Worlds.


**Keywords:** Chronology, Radiocarbon dating, Norse expansion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Non-Classical Logics and Fuzzy Inferences – Theory and Applications'.

assistant: **Innovation**

The goal of the proposed research covers the following two topics:1. Theoretical foundation and investigation of different fuzzy inferences: There is a tremendous number of applications in daily life and industry where fuzzy theory is successfully applied. Those methods usually are based on a fuzzy inference. Therefore the mathematical foundation of fuzzy inferences as well as the finding of new methods which are superior to the ones applied today is an important task. Thus, this research supports the theoretical foundation of several fields of Artificial Intelligence and Software Engineering such as fuzzy control, knowledge-based systems, search engines on the web, and leads to industrial applications too.2. A study of mathematical fuzzy logics in relation to substructural logics, based on results and techniques developed recently in the study of substructural logics: Finding algebraic characterizations of different subclasses of left-continuous t-norms and residuated lattices. Further extending the geometric approach, developed in mathematical fuzzy logics by the applicant, to substructural logics. New findings at this line of the research could be very beneficial in supporting the research goals of point 1 too. A final aim is to develop a study of interrelations between algebraic methods and proof-theoretic methods in non-classical logics, in particular, in substructural logics, and in mathematical fuzzy logics in order to obtain a deeper understanding of these two disciplines.