RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'nexT gEneRation sMart INterconnectEd ioT' in the context of a Horizon 2020 call.

assistant: **Objectives**

The vision of TERMINET is to provide a novel next generation reference architecture based on cutting-edge technologies such as SDN, multiple-access edge computing, and virtualisation for next generation IoT, while introducing new, intelligent IoT devices for low-latency, market-oriented use cases. TERMINET’s primary intention is to bring (more efficient and accurate) decisions to the point of interest to better serve the final user targeting at applying distributed AI at the edge by using accelerated hardware and sophisticated software to support local AI model training using federated learning. Our solution aspires to reduce the complexity of the connecting vast number of heterogeneous devices through a flexible SDN-enabled middleware layer. It also aims to design, develop, and integrate novel, intelligent IoT devices such as smart glasses, haptic devices, energy harvesting modules, smart animal monitoring collars, AR/VR environments, and autonomous drones, to support new market-oriented use cases. Great expectation of the proposal is to foster AR/VR contextual computing by demonstrating applicable results in realistic use cases by using cutting-edge IoT-enabled AR/VR applications. By designing and implementing an IoT-driven decentralised and distributed blockchain framework within manufacturing, TERMINET aims to support maintenance and supply chain optimisation. Our solution intends to apply a vertical security by design methodology by meeting the privacy-preserving and trust requirements of the NG-IoT architecture. To foster standardisation activities for the IoT ecosystem, TERMINET will provide novel disruptive business models. For the evaluation of its wide applicability, TERMINET will validate and demonstrate six proof-of-concept, realistic use cases in compelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Clinical Phase IIB trial with 2OHOA in patients with newly-diagnosed malignant glioma.'.

assistant: **Concept**

Glioma is a rare brain cancer with one of the highest mortality rates. It is considered an orphan disease due to its low prevalence (less than 0.5 cases per 10,000 inhabitants in the EU) and the lack of plausible therapies. Based on the discovery of the lipid proliferation switch (high membrane PE-to-SM molar ratio that enables recruitment of cell growth transducers to the membrane), the SME Lipopharma (leading this application) defined a novel anticancer drug target, the tumor repressor protein sphingomyelin synthase 1 (SMS1). An innovative SMS1 activator, 2OHOA, was designed and showed safety and efficacy in preclinical GLP and non-GLP studies. A first-in-man clinical trial I/IIa (ClinicalTrials.gov identifier #NCT01792310) further demonstrated its safety and efficacy in humans. The European Medicines Agency (EMA) designated 2OHOA orphan drug for the treatment of glioma and approximately half of the patients with glioma submitted to >2 months of treatment showed positive response. The present project aims to perform a clinical phase IIB study to demonstrate 2OHOA’s efficacy against glioblastoma multiforme, the most aggressive form of glioma. In this context, a written formal report from the EMA after scientific advice and protocol assistance (SA/PA-EMA/CHMP/SAWP773534/2014) indicates that 2OHOA would obtain Conditional Marketing Authorisation if this phase-IIB study further demonstrates statistically significant efficacy. In addition this project will further investigate 2OHOA’s safety, mechanism of action and biomarkers for glioblastoma diagnosis, prognosis and response to 2OHOA treatment. These studies will let us (i) know the molecular basis underlying the response to 2OHOA treatment, (ii) define new biomarkers, (iii) design more efficacious personalized treatments
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Continuous business process assurance for the age of digital transformation' under Horizon 2020.

assistant: **Concept**

Mollymawk is a business process assurance (BPA) SaaS solution that provides complete continuous business process-oriented software testing. Mollymawk is different from numerous software testing tools that are already successfully used in the enterprise. While existing solutions focus on validating individual features in specific applications, Mollymawk ensures that the complete business processes continue to work without disruptions to the enterprise’s customers.Mollymawk is designed to work in large-scale complex enterprise environments (with a large variety of desktop, web, mobile applications, both custom-made & off-the-shelf). It ensures that the enterprise business process objectives & KPIs (defined by senior management) are shared by the development/QA teams and drive the development, testing & roll-out of new features & fixes. By creating transparence about the business processes through the full application footprint, it increases testing & validation efficiency of teams by up to 800%—defects that might have a disruptive impact on the enterprise’s customers get eliminated at the earliest stage.Mollymawk is developed by Smartesting—a French SME with strong market traction in model-based testing tools & continuous automated testing processes. Smartesting has released Yest—a workflow-based test design tool for enterprise IT systems and CertifyIt—a model-based testing tool for security component testing. Mollymawk is designed by Bruno Legeard—a recognized global expert on IT quality assurance. Mollymawk is the first continuous business process assurance platform on the market aimed at 10,000+ users by 2023 (€15m+ & 3%+ BPA market share) and 100,000+ users by 2027 (€120m+ & 24%+ BPA market share).In this Phase 1 project Smartesting will work on a report that contains
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Precise online tracking for high energy physics event selection at CDF' (POT), addressing dissemination and exploitation.

assistant: **Impact**

This project is a 'second generation' real time tracking system for the CDF experiment. We have developed the 'first generation' and we are now working on the upgrade. Our project consists in the exploitation and optimization of the upgrade to improve as much as possible the CDF physics program. The CDF experiment is located at the Tevatron hadron collider at Fermilab, a USA national laboratory near Chicago.At present, the Tevatron is the particle accelerator providing the highest center-of-mass energy in the world. It accelerates protons and antiprotons, and then makes them collide head-on inside the CDF detector. The CDF detector is used to study the products of such collisions. The beginning of the XXI century appears to be very exciting for high energy physics: the Tevatron at Fermilab and later on the new powerful hadron collider, the LHC at CERN (the European laboratory located near Geneva), may give conclusive answers in many sectors of fundamental physics, e.g. super-symmetry, Higgs boson, and CP-symmetry violation. This project will have an important impact on this high energy physics program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NetworkNature - Advancing nature-based solutions together' (NetworkNature).

assistant: **Concept**

NetworkNature will establish a European and global platform allowing all interested stakeholders to access and contribute cutting-edge, innovative knowledge and expertise on nature-based solutions (NBS). Our consortium represents all relevant stakeholder groups and has access to a range of related networks. We have a strong track record and extensive expertise on this topic in terms of engagement, content, technical know-how and involvement in relevant policy processes at European Union (EU) and global level. This allows us to maximise the EU’s potential to become a global leader in deploying innovative NBS to address societal challenges, building on the ongoing work of all Horizon 2020 and BiodivERsA-funded NBS projects as well as relevant other initiatives and programmes in Europe and beyond. The project’s legacy will be ensured through establishing a sustainable platform structure that responds to the needs of the NBS community of innovators based on a sound and stable business model; providing support to and strengthening the NBS community, particularly small and medium enterprises, practitioners and policy-makers, to foster market uptake as well as the transfer and application of innovative NBS; by providing targeted dialogue opportunities across Europe and in regions, guidance and capacity building as well as using advocacy as vehicle to nurture NBS through policy, research and practice, particularly for design and standardisation; and, finally, by building on existing global initiatives to continue enhancing international cooperation to upscale the implementation of NBS. NetworkNature will help transform the EU’s vision of becoming a leader for NBS into reality through a comprehensive, up-to-date, open, user-oriented platform for NBS, building on the dynamic, but
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Defining novel mechanisms critical for colorectal tumourigenesis' (COLGENES).

assistant: **Innovation**

Cancer genome sequencing has led to a paradigm shift in our understanding of oncogenesis. It has identified thousands of genetic alterations that segregate into two groups, a small number of frequently mutated genes and a much larger number of infrequently mutated genes. The causative role of frequently mutated genes is often clear and are the focus of concerted therapeutic development efforts. The role of those infrequently mutated is often unclear and can be difficult to separate from ‘mutational noise’. Determining the relevance of low frequency mutations is important for providing a full understanding of processes driving tumourigenesis and if functionally relevant may have broader implications on the applicability of targeted therapies.This project aims to begin addressing this by defining the function of all genes mutated in colorectal cancer (CRC) in the earliest stages of tumour formation. I have performed a whole genome screen in a 3D organoid CRC initiation model identifying several potentially important mediators of this process. Crucially, some of these genes are mutated in CRC at low frequency but not described as cancer driver genes. Thus, I hypothesize that rather than ‘mutational noise’ infrequently mutated genes contribute to CRC initiation. I will test this by addressing two aims:1) Determine the role of genes mutated in CRC during tumour initiation2) Validate and determine the function of a subset of identified genes potentially defining novel cancer mechanismsI will use a combination of CRISPR genetic disruption in state-of-the-art 3D mouse and human organoid cultures and advanced mouse models to address these aims. This comprehensive approach will provide a foundation for understanding the importance of the entire spectrum of mutations in CRC and op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Superplastic deposition of ceramic coatings'.

assistant: **Innovation**

Experimental trials carried out in this project showed that the addition of oxide systems to silicon nitride markedly increases the flow of feedstock particles at impact with the substrate during thermal spray deposition. Extensive particle flow is essential for the formation of high-performance coatings. A quantitative model for the flow of particles at impact has been developed in terms of strain rate, impact velocity, particle size and second-phase content. A number of matrix systems including yttria-alumina-silica, yttria-alumina, alpha-alumina, gamma-alumina and mullite have been selected on the basis of the model and investigated. Process routes for composite feedstock powders have been developed using sol-gel techniques, spray-drying and nitrogen-sintering. An individual particle in the feedstock powders consists of a dispersion of fine silicon nitride particles in a matrix of each of the latter oxide systems. A series of powder compositions with a range of silicon nitride contents and sizes for each matrix type was prepared. Subsequent plasma spraying trials showed that the experimental results were consistent with the theoretical model. It was shown, for example, that the presence of fine silicon nitride particles and silica in glassy phases drastically reduces particle flow. The model has enabled the powders for each type of matrix system to be optimized.Evaluation of the coatings showed that major improvements in coating quality were achieved throughout the project by following the model. The performance of the coatings as assessed by the industrial partners was comparable with that of existing industrial state-of-the-art coatings. The problems of agglomeration of the fine silicon nitride particles and poor splat flow have been overcome such that well separat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Refining our view on planet Mercury, in anticipation for the BepiColombo mission.' (MERCURYREFINEMENT).

assistant: **Concept**

As the inner-most object of our solar system, planet Mercury is of unique relevance for e.g., solar system dynamics, planetary formation theory, and terrestrial magnetic field generation. So far, two single (NASA) space missions to Mercury have been performed. In 2018, ESA and JAXA will launch the dual-satellite BepiColombo to study Mercury from orbit with the largest and most advanced payload to date. BepiColombo’s formal objectives have been formulated prior to NASA’s latest space mission to Mercury (MESSENGER). It is now time to use MESSENGER's data return to refine our view on Mercury as support for BepiColombo’s measurement phase, starting December 2025.In this fellowship, MESSENGER data will be used to re-investigate Mercury’s interior structure, magnetic field and surface age. At the Royal Observatory of Belgium, advanced core-composition specific models on the planet’s interior will be developed. These will incorporate new experimental data on relevant metallic core-alloys which will be obtained at the High-Pressure laboratory of the VU University in Amsterdam and at synchrotron facilities. The potential of future geophysical measurements to constrain Mercury’s core composition will be the emphasize of these models.Dynamo simulations will be performed at the Max Planck Institute for Solar System Research to study Mercury’s magnetic field generation for a suite of dynamo constraints. These will improve constraints on the core’s dynamic state, which relates to the planet’s structure and core composition.Also, a new crater-counting-based surface dating method will be developed and calibrated by new models for the inner solar system’s dynamics. Applied to Mercury, this method will refine its surface age and its geological evolution and informs on the evolution and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hantavirus infections in Europe: Molecular virology, epidemiology and ways of control' under Fourth Framework.

assistant: **Concept**

- To understand the molecular mechanisms of hantavirus replication and to define potential targets for antiviral therapy.- To determine the extent of genetic variation of known hantaviruses in rodents and humans and to define the distribution of hantavirus infections and diseases in Europe and to isolate novel European hantaviruses.- To elucidate mechanisms underlying the development of disease. Biological factors for transmission of infection from rodent to man and the possible control of such factors will be investigated.- To develop reagents for antiviral therapy and immune intervention and to further develop a candidate vaccine now shown to be efficient in an animal model.Brief descristion:Hantaviruses are important European pathogens, transmitted to humans from chronically infected rodents. Hantaviruses cause hernorrhagic fevers with renal syndrome and hantavirus-associated pulmonary syndrome and are prime examples of emerging and re-emerging viruses. We wish to understand the molecular mechanisms of hantavirus replication using reverse genetics and studies on hantavirus protein-RNA and protein-protein interactions. This work also aims to define potential targets for antiviral therapy. We plan to to determine the extent of genetic variation of known hantaviruses in rodents and humans and to define the distribution of hantavirus infections and diseases in Europe. We will also continue efforts to isolate novel European hantaviruses. We elucidate mechanisms underlying the development of disease, including definition of the primary site of infection and the nature of the inflammatory host response. We develop reagents for antiviral therapy and immune intervention (synthetic peptides, recombinant gene products) and to further develop a candidate vaccine now shown to be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular origin and function of dynamic heterogeneities in mouse ES cells and pre-implantation embryos' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The mechanisms powering the transition from one cell state to another are the central engine of embryonic development. Genetic analysis over the last twenty years has provided us with a catalogue of genes and proteins that can be linked in linear and time dependent manners to specific states and transitions in this process. However this picture, characterized by complex charts of univocal relationships between different genes, is static and rigid and contrasts with the plasticity displayed by cells in many processes, in particular during repair and regeneration. The early mammalian embryo and the closely related ES cells provide extreme examples of this in the form of toti- and pluri-potency i.e. the maintenance of an open uncommitted state from which all cell types emerge. Understanding the molecular basis of these uncommitted states and the way they are established and regulated will not only provide a deeper insight into the operation of biological systems but will also new targets for regulation and therapies. This project revolves around the hypothesis that the plasticity displayed by cells in developmental and regulative processes is associated with dynamical cellular heterogeneities generated by transcriptional noise: phenotypic variability in genetically identical cells that arises from stochastic fluctuations during transcription and translation. Specifically I propose to provide measurements and analysis of gene expression noise in mammalian cells, its origin, regulation and use using ES cells and early mouse embryos as experimental systems.