RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TRANSFER OF DETENTE INSTANTANEE CONTROLEE DIC" TO THE AGRO-FOOD AND PHARMACEUTICAL SECTOR"' (DIC), addressing dissemination and exploitation.

assistant: **Impact**

This project plans to realise the transfer of DIC (fast drying) technology to the food and pharmaceutical industries toward a semi- industrial scale installation permitting a scaling up" of the processes, new products and equipment so as to. - produce new DIC products in sufficient quantity for market studies and uses - ensure technical support to SME wanting to use the technology. - Minimise the technological and economical risks specific to this emerging technology."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Qualification Methodologies and Certification of Adhesive Bonding Procedure in the Automotive Component Industry' under Fourth Framework.

assistant: **Concept**

Adhesive Tcchnology has been increasingly applied within the Automotive sector in the last 20 years. Although this joining technology is aiready used with full confidence in this industry, no specific standards for qualification of the bonding proccdure and operators as well as for its certification is known. In fact, the joint reliability and quality assurance is in most of the cases carried out by internal specifications or demanded by the car manufacturer, represented by large enterprises as FORD-VOLKSWAGEN, TOYOTA, RENAULT, Etc. Adhesive bonding is considered by ISO 9001 as a special process and therefore there is a need for qualification and certification of procedures and operators. The aim of this project is to define methodologies for the qualification and certification of adhesive bonding procedures and operators applied to the joining of automotive components. Adhesive bonding specifications and qualification variables will be defined accordingly to the product to be produced. Finally, it is expected to produce a common specification within the sector through the standarization of the main adhesive bonding qualification variables. A feasibility study will be carried out in order to allow lo define an adequale survey and lype of lests for lhe qualification methodology. The results of this project will be a step forward in the quality of the product and will allow a closer collaboration between European SME`s automotive components due to a common standard language within the adhesive bonding qualification which will enable the joint-venture" between them. Moreover, it is expected to extend the methodologies developed to other industries in which adhesive bonding is used as a prime joining technique in which the qualification of the process is required by ISO 900
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Through process modelling of forming and formability of aluminium sheets and profiles (VIRFORM)'.

assistant: **Objectives**

This RTD project aims to improve productivity and product quality and to enable innovative solutions to future demands on safety, environment, design and user-friendliness. Products in this context are aluminum components for use mainly in transportation, but also products used in the building and packaging industry will be covered. The main output of the project is through process micro structurally based models with application to forming and formability of rolled sheets and extruded profiles of aluminum alloys.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DEsigning new Paths in The differentiation Hyperspace' (DEPTH).

assistant: **Innovation**

The adult human organism contains heterogeneous reservoirs of pluripotent stem cells characterized by a diversified differentiation potential. Understanding their biology at a system level would advance our ability to selectively activate and control their differentiation potential. Aside from the basic implications this would represent a substantial progress in regenerative medicine by providing a rational framework for using small molecules to control cell trans-determination and reprogramming.Here we propose a combined experimental and modelling approach to assemble a predictive model of mesoderm stem cell differentiation. Different cell states are identified by a vector in the differentiation hyperspace, the coordinates of the vector being the activation levels of a large number of nodes of a logic model linking the cell signalling network to the transcription regulatory network.The premise of this proposal is that differentiation is equivalent to rewiring the cell regulatory network as a consequence of induced perturbation of the gene expression program. This process can be rationally controlled by perturbing specific nodes of the signalling network that in turn control transcription factor activation. We will develop this novel strategy using the mesoangioblast ex vivo differentiation system. Mesoangioblasts are one of the many different types of mesoderm stem/progenitor cells that exhibit myogenic potential. Ex vivo, they readily differentiate into striated muscle. However, under appropriate conditions they can also differentiate, into smooth muscle and adipocytes, albeit less efficiently. We will start by assembling, training and optimizing different predictive models for the undifferentiated mesoangioblast. Next by a combination of experiments and modelling app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Inkjet Printed Sensor Arrays for high efficient, low cost, environmental monitoring' under Horizon 2020.

assistant: **Concept**

IPISA aims at enabling CETRI to recruit a specialist to join our team developing a smart sensor array of chemoresistive sensing elements for measurement of Volatile Organic Compounds and other hazardous gas. The sensor is innovative because its multi-material design and advanced data processing algorithms make it suitable for a number of applications and gases. The development work foreseen is on the synthesis, patterning (using inkjet printing and microfabrication techniques) and characterization of sensing elements to make the gas sensor exploitable with the highest efficiency. The IPISA proposal aims at exploiting an ultra-versatile sensing scheme based on the development of high-performance, low-cost, printed sensor array technology in order to fulfill the ever growing need for environmental monitoring. Α plethora of fields is expected to be benefited from such a technology in the near future, such as the industrial environment monitoring for labour safety and urban environment monitoring for the life quality monitoring. Moreover, the high societal impact of such a sensing scheme technology is reflected on current needs for enhanced safety monitoring in populated area, such as airports for the convenient detection of explosives, and fields where the knowledge of the exact environmental conditions is of paramount importance such as agriculture, livestock, pisciculture, etc. The specialist will also be working on the commercialization of the device and will formulate an holistic innovation strategy for market penetration of the sensor produced. For that purpose,  a training program in innovation management and business management will be offered as part of the project (organised by the European Commission), as well as an internal training program in order to smoothly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Design of International Institutions: Legitimacy, Effectiveness and Distribution in Global Governance', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

One of the most profound trends in global governance over the past two decades is the growing extent to which international institutions offer mechanisms for the participation of transnational actors. This project will explore two central research questions, pertaining to the causes and effects of this shift in the design of international institutions: (1) Why have international institutions increasingly opened up to transnational actor involvement? (2) What are the consequences of involving transnational actors for the democratic legitimacy, problem-solving effectiveness, and distributional effects of international institutions? These are research questions that previously have not been explored systematically in existing literatures on international institutional design, transnational actors in global governance, and democracy beyond the nation-state. This project opens up a new research agenda on the design of international institutions through an ambitious combination of novel theory development and comparative empirical research. Theoretically, the project develops and tests alternative hypotheses about the causes and effects of transnational participation in international policy-making. Empirically, the project explores the dynamics of transnational participation through comparative case studies of five major international institutions, supplemented with a large-n mapping of formal mechanisms of transnational access in a broader sample of institutions. The project will help to establish an internationally competitive research group of post-doc researchers and Ph.D. students devoted to international institutional design, and consolidate the position of the principal investigator as a leading researcher in this field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation of early embryo development and pluripotency through alternative splicing' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding how the differentiation potential of the mammalian embryo gets restricted during development is a key question in the embryology and stem cell fields. Alternative splicing (AS) is the process by which different exons are selected in precursor mRNAs to generate multiple protein products. Recent studies have shown that 95% of human multiexonic genes undergo AS, however little is known regarding its role in modulating pluripotency and differentiation. The aim of this project is to study the role that AS plays in these processes. For this we will first use ultra-deep coverage RNA-sequencing data from three mammalian species to identify alternative exons that show conserved dynamic usage during early developmental stages. Second, we will functionally test in ESCs the role of a number of these isoforms in pluripotency maintenance. Finally, we will take advantage of the CRISPR-Cas9 technology to generate exon specific knockouts in mouse embryos in order to assess their role during early embryo development. The results obtained from the proposed research will add to our knowledge of the regulatory networks that control early embryo development and will improve our understanding of the biology of stem cells, which is essential for their effective use for therapeutic applications. In addition, the use of state-of-the-art technology and a multi-disciplinary approach to analyze mammalian pluripotency regulation will improve my expertise in this field, helping me to gain independence in the near future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Probing the frontiers between conscious and non-conscious neural processing: conscious retrieval of fading information, non-conscious processing of undegraded information'.

assistant: **Concept**

Conscious access to information, e.g. visual information, is accompanied by increased activity both in sensory areas and in a distributed fronto-parietal network, with increased coupling between the two. However, the neural events leading to these changes in brain activity are relatively unexplored. It is well established that events occurring after the presentation of a visual stimulus can, surprisingly, still determine whether it will enter consciousness, but the neural mechanisms are unknown. I will study two classic and complementary examples of this situation: partial report and object substitution masking. Because, in each case, the events giving rise to a stimulus entering or being denied entry to consciousness occur after stimulus presentation, I will be able to dissociate neural mechanisms associated with stimulus presentation and conscious access. I will use these paradigms to probe the spatial and temporal limits of non-conscious processing, and to assess which neural processes can occur long after stimulus offset to allow conscious report. To achieve this goal, I will combine the high spatial resolution of high field functional Magnetic Resonance Imaging (fMRI) with the high temporal resolution of Magneto-Encephalography (MEG). In the partial report paradigm, I will investigate whether activity in early sensory areas (outlined very finely with retinotopic mapping) is enhanced by the cue long after stimulus offset, and whether this increase is linked to enhanced long distance connectivity. With MEG, I will study the detailed timecourse of these neural mechanisms. Finally, analogous studies of object substitution masking with fMRI and MEG will allow me to probe the depth, the strength and the temporal limits of non-conscious sensory processing of an un degrade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multimodal optical interrogation of neural activity and neuromodulation during sequence processing', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The world often presents us with sequences of multisensory stimuli unfolding over time, like a car appearing after we hear it approaching. In the cerebral cortex, individual neurons integrate information across senses and time in order to identify these objects. Meanwhile, neuromodulatory molecules shape neural computations, adapting them to context and experience. It is from this interplay that the spatio-temporal patterns of neural activity containing the code for how we perceive the world originate. However, these activity patterns have long been experimentally inaccessible, and they have never been investigated concurrently to neuromodulation. With this project, I will reveal the causal role of functionally-identified ensembles of neurons in the perception and learning of audio-tactile sequences. I will combine, for the first time, two-photon (2p) imaging and holographic-optogenetics with fluorescent neuromodulation sensors. My experiments will be performed in the posterior parietal cortex (PPC) of the mouse, a multimodal area acting as sensory history buffer. I will focus on noradrenaline (NA), a modulator so far involved in sharpening processing of weak unisensory features. I will 1) test which PPC neurons are sufficient, when activated, to bias perception of multisensory sequences during a behavioural task; 2) simultaneously, I will test whether and how PPC levels of NA change when altering sequence discriminability. My experiments will be supported by a solid theoretical framework based on Information Theory. In conclusion, I will use a unique combination of advanced molecular, optical, and computational tools to pursue a novel, causal and integrative approach to cortical function: one where functional neuronal subgroups and neuromodulation are investigated toge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microbiota-immune interaction in colorectal cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

The human gastrointestinal tract harbours trillions of bacteria that have co-evolved to play important roles in health and disease, conferring immunological, metabolic and neurological benefits to the host. This assemblage is known as the Gut Microbiota and has been a focus of investigation over the last decade. Altered gut microbiota composition has been associated with colorectal cancer (CRC), and studies in germ-free mice established an important role for some gut microbiota members in oncogenesis outcome, tumour progression and response to therapy. Data from the host laboratory show that patients with CRC harbour specific gut microbiota sub-types, among which some are associated with distinct mucosal gene-expression profiles. Thus either directly or through their metabolites, these tumour-associated microbiota appear to differentially recruit and interact with host inflammatory cells, which we hypothesize may be involved in different outcomes of carcinogenesis. The presence of particular immune cells is known to be prognostic of clinical outcome, because it often creates a tumour-promoting environment. Therefore, strategies aimed at manipulating the tumour-associated microbiota in CRC represent a promising therapeutic approach for patients. IMMUNO-CRC’s goal is to elucidate the mechanisms by which certain bacterial sub-types associated with CRC may alter immune function and influence clinical outcome. Using multicolour flow cytometry, I will analyse infiltrating immune cells characteristic of different inflammatory responses and microbiota sub-types. Histo-immunophenotyping analysis on tumour biopsies will determine their inflammation and cancer phenotype. Metabolomics will identify specific microbial metabolites involved in the regulation and progression of inflamm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Spatiotemporal regulation of T-cell Priming' under Horizon 2020.

assistant: **Concept**

The initiation of adaptive cellular immunity requires antigen-specific interactions between Dendritic cells (DC) and naive CD8 T cells in secondary lymphoid organs. We aim to understand how the dynamic migratory behavior of myeloid and lymphoid cells is coordinated to ensure that “the right cells” communicate at “the right time” in “the right place” to enable robust immune responses. Using intravital microscopy, we have recently identified a critical phase (“Step 2”) of T cell priming that follows the initial encounter of DC and CD8 T cells and is essential to develop protective immunity.The aim of this proposal is to identify the cellular and molecular mechanisms regulating T cell differentiation during Step 2. We will employ a newly developed imaging method (“Net-Vis”) to investigate how key elements of Step 2 (XCR1 DC) receive antigenic and inflammatory “information” within a network of myeloid cells. Next, we will test a novel model of T cell priming in which stepwise relocalization to multicellular clusters within the LN orchestrates T cell differentiation. Combining deep-tissue intravital microscopy, “Niche-seq” and novel genetic approaches, we will identify the cellular players and molecules guiding these processes and test their mechanistic implications. Finally, we will investigate the identity and mechanisms of Foxp3+ T cells that co-regulate CD8 T cell activation and differentiation during Step 2. In summary, we will exploit an array of innovative imaging, spatiotemporal transcriptomics and genetic approaches to investigate novel fundamental aspects of CD8 T cell priming during a newly discovered distinct phase of T cell activation and differentiation. Investigating the mechanisms that guide these central steps in adaptive immunity is anticipated to reveal ne