RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Metabolic control on NF-κB activity during dendritic cells-mediated immune tolerance to tumours'.

assistant: **Objectives**

BACKGROUND: Dendritic cells (DC) are professional antigen presenting cells able to provide protective immunity to cancer. DC undergo functional maturation that can lead to tolerogenic phenotype associated with immune-suppression in cancer by a still unknown mechanism. Recently the host laboratory revealed a new role of IKKβ/NF-kB signalling in the tolergenic function of DC. However, the upstream regulators of this signalling and its implication in cancer have not yet been addressed. Since malignant cells consume high amounts of nutrients and DC become tolerogenic in low nutrient conditions possibly under the control of the master energy sensor AMP kinase (AMPK), a pseudo-starvation state in tumour-associated DC (TADC) may be responsible of their tolerogenic activity. AIMS: To determine the metabolic role of AMPK and the potential links with IKKb/NF-kB signalling in the tolerogenic activity of TADC in melanoma context. METHODS: I will use mice with a deletion of IKKβ in DC (IkbkbΔItgax) generated in the host laboratory and will generate mice with a deletion of AMPK in DC (Ampka1ΔItgax). Isolated DC will be cultured in high/low nutrient conditions or in the presence/absence of melanoma cells. Activation of AMPK and IKKβ/NF-kB signalling will be analyzed in these conditions and correlated with DC maturation. TADC will be analyzed in vivo using a mouse melanoma model with conditional melanocyte-specific expression of BRafV600E combined with PTEN deletion. The contribution of IKKβ and AMPK activation in TADC during tumour development will be assessed using (i) a skin graft model from BRafV600E mutant mice to IkbkbΔItgax and Ampka1ΔItgax mice and (ii) chimeric mice generated with bone marrow cells from IkbkbΔItgax and IkbkbΔItgax mice transferred to irradiated BRafV600E mutan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Information Systems for Combined Mobility Management in Urban and Regional Areas' in the context of a Fifth Framework call.

assistant: **Objectives**

The ISCOM projects (R&D IST-1999-11425 and Demonstration Part IST-1999-71425) consist of the development, demonstration and validation of electronic timetable information and the set-up of mobility centres in the regions of Alsace (Regio Alsace) and Baden Wurttemberg as well as in the metropolitan areas of Rome and Vienna. The City of Stuttgart in Baden-Wurttemberg will additionally emphasise the improvement of traffic management functions, especially congestion information. To this aim, the different sites represent the regions with the cross-border aspect and the European capitals with the mass transport problem. The transport services on the digital network are accessible either by end users directly as an internal service, or by operators staffing the mobility centre. The aim is to provide a value-added service on digital communication networks with a broad range of services for transport agencies and for road users. The evaluation will determine the user acceptance and traffic impacts due to changing behaviour.Objectives:The overall objective of ISCOM projects consists of the development and demonstration of multimodal transport information and services to raise quality of life in the daily experience and in mobility in general. There is a need to overcome cross-border limitations in intermodal transport as well as reducing congestion, environmental pollution, energy consumption and accidents in road traffic. The aim is to create user-friendly applications of multimodal transport information and services, to improve transport and congestion management, support intermodal transport, create user-friendly interfaces, and to improve efficiency through adaptation of existing electronic timetable software to different areas. Specific traffic information and service for h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Career Advancement for Refugee Researchers in Europe' (CARe) targeting Horizon 2020.

assistant: **Abstract**

While the high influx of asylum seekers poses an enormous pressure on the host countries (nearly 3.8 million new asylum applications recorded in Europe in the years 2015-2017), studies of previous large-scale migration movements reveal insights into positive effects of welcoming refugees and significant economic returns of investments into refugees. Although exact figures are missing, there is some evidence indicating that a significant part of the refugees is highly skilled. This suggests that a substantial number of refugees could potentially contribute to the European Research Area as well as the economies and societies of their host countries and the European Union (EU). It is therefore of utmost importance to provide the job seekers with coordinated and needs-based support in job search and match making with the employers seeking work force of their competence and expertise. The CARe project (Career Advancement for Refugee Researchers in Europe) is a 21-month project that aims to support the labour market integration of refugee researchers through coordinated and tailored provision of information needed for their entry and integration in R&D market. It targets 10 European countries with high numbers of asylum seekers, the absorption capacity of the R&D labour market and proven political will to support the labour market integration of refugee researchers (Austria, Belgium, Finland, France, Germany, Ireland, Norway, Sweden, Switzerland and the Netherlands). The project objectives will be achieved through a set of research and dissemination activities that will on the one hand, provide needs-based and country-specific information on the labour market conditions and requirements for refugee researchers, and on the other, provide Europe-wide platforms for results disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'User-oriented Solutions for Improved Monitoring and Management of Biodiversity and Ecosystem services in vulnerable European Seas' (B-USEFUL), addressing dissemination and exploitation.

assistant: **Impact**

The biodiversity, health and services of European marine ecosystems is severely threatened as cumulative human pressures and impacts continue to spread and increase throughout our seas and along our coasts. In order to put biodiversity on the path to recovery and thus achieve the ambitious policy goals set out by the EU Green Deal and the Biodiversity Strategy 2030, we need well informed science advice and operational decision-support tools allowing end-users to decide on conservation actions for biodiversity protection (e.g., MPAs), while at the same time seek to minimize trade-offs with other human use of ocean space (e.g., fishing, off shore energy and shipping). B-USEFUL will develop and deliver user-oriented solutions fit for uptake and implementation in decision making by effectively building upon existing European data infrastructures and governance frameworks for ecosystem-based management advice and marine spatial planning. This will be achieved by delivering upon the following objectives (here presented in short form) addressing the expected outcomes and impacts of the call and destination, namely to: (i) identify end-user needs; (ii) co-develop biodiversity indicators, targets and scenarios; (iii) create a standardized biodiversity and pressure data base; (iv) assess the status and cumulative impacts on biodiversity; (v) quantify risk and vulnerability to biodiversity loss; (vi) perform model forecasts of changes in biodiversity and ecosystem services; (vii) co-develop an interactive, online decision-support tool fit for management strategy evaluation of actions ensuring biodiversity protection.The project will embrace a process of co-creation where all outputs are iteratively co-developed, validated and approved by end-users. This serves not only to build mu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Generating yeast biodiversity by mitochondrial introgression for wine innovation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Wine global demand is decreasing due to a shift in consumer preferences and cultural changes. The EU is a GLOBAL LEADER in WINE production, whose wine companies wants to decrease ethanol content, while improving organoleptic properties to deal with these new demands. YEASTS, mainly Saccharomyces cerevisiae, play a KEY ROLE during wine fermentation, when alcohol and the main flavors are produced. Application of new yeasts, produced by genetic engineering, is limited due to the non-acceptance of Genetically Modified Organisms (GMOs). We PROPOSE to apply non-GMO methodologies, to obtain IMPROVED YEASTS by the generation of yeast strains (cybrids), with mitochondrial genomes (mitogression) from non-cerevisiae species, or hybrids, increasing yeast DIVERSITY, to select strains whose fermentation products match wine company expectations. We will ANSWER some BASIC research QUESTIONS: how is genotype molded by the presence of a foreign mitochondrial genome? Are these changes common between independent experiments and wild isolates? And, are evolved strains starting to show evidence of speciation from their ancestors? The results of this project will IMPACT the WINE INDUSTRY by generating new potential commercial strains, and future collaborations. The knowledge gained through this proposal will demonstrate to the scientific community the use of novel methodologies as well as expose the general public to the importance of biodiversity for industrial processes and how the transfer of genetic material and experimental evolution can produce beneficial traits for our societies. The researcher (evolutionary biology and bioinformatics background), supervisor (microbiology, systems biology, and synthetic biology background), and host institution (facilities, knowledge, experience, and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Precision tools for high-energy QCD scattering at the LHC and Auger', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main goal of this project is to develop theoretical and phenomenological tools in the framework of Quantum Chromodynamics (QCD) at high gluon densities oriented to the understanding on data from the Heavy Ion program at the LHC and from the Pierre Auger Observatory  on cosmic rays.One main goal of this proposal is to provide a precise characterization of the initial state of heavy ion collisions in order to allow a precise extraction of the transport parameters of the produced medium, presumably a Quark Gluon Plasma. This implies achieving a precise description of the full phase space and collision geometry dependence of the initial quark and gluon distributions and their correlations.The theoretical work of this project focuses in the calculation of higher order corrections to the Color Glass Condensate (CGC) effective theory for QCD high-energy scattering, both at the level of the non-linear evolution equations and of production processes.The theoretical results shall be used to build a Monte Carlo simulation tool for the characterisation of the initial stages of proton and nuclear collisions. The small Bjorken-x component of the nuclear wave function, a key ingredient for the  calculation of any production processes studied in this project, shall be constructed under the Gaussian approximation and empirically constrained through global fits to data from several collision systems (e+p, p+p, p+A and A+A).Other objective of this project is to translate the advances in our understanding of high-energy QCD scattering gained by the detailed study of LHC data into the simulation tools used in the analyses of Ultra High Energy Cosmic Rays. This will allow for theoretically well constrained extrapolations over more than two orders of magnitude in the collision energy of s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigation of a dependency of RAS-driven cancers on matrix metalloproteinase-7' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Activating point mutations in RAS are present in a large number of tumours. Besides treating tumours by reversing the effects of oncoproteins through inhibition, another approach is to use therapies that target tumour-specific vulnerabilities caused by the oncogenic state. To investigate this possibility, an siRNA screen has been performed in order to identify new genes necessary for the RAS-driven oncogenic state. This approach has led to the identification of the matrix metalloproteinase-7 (MMP-7) as a protein required for the survival of cells with an activated KRAS allele. MMP-7 is a member of the matrix metalloproteinase family that has broad substrate selectivity against extracellular matrix components and some non-matrix substrates. MMP-7 is overexpressed in a variety of tumours and is associated with unfavourable prognosis. The main aim of this project is to study the mechanism underlying the dependency of cells with RAS activating mutations on MMP-7 expression. To determine this we will study four different pathways. MMP-7 can suppress apoptotic FasL/Fas pathway by cleaving FasL and reducing its efficacy in triggering Fas signals. Alternatively, MMP-7, by cleaving E-cadherin, can increase β-catenin-Wnt pathway, which is required by several tumour types. Moreover, MMP-7 proteolysis of IGFBP-3 plays a crucial role in regulating IGF-I bioavailability, thereby promoting cell survival. Finally, MMP-7 can process HB-EGF that will activate ErB4 signalling. This leads to a survival signalling through receptor tyrosine kinases. We will also study MMP-7 dependency in vivo using MMP-7 knock-out mice crossed with a RAS mutated mouse model. Results obtained may lead to improved cancer therapies, with the possibility that certain tumour types with high levels of RAS mutation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of analytical based software for the evaluation of industrial systems reliability'.

assistant: **Concept**

The objective of the RELYSOFT project is to develop innovative, friendly software for a consistent evaluation of any type of system reliability in function of time at a reasonable cost. The intended system, being based on purely analytical models and available data on materials characteristics and tolerances, will not require experimental data or too high software complexity and will therefore be affordable also to SMEs. The system will be based on the Failure Equation approach and is very innovative in that it is intended to represent in a totally analytical way the operative links among random quantities considering any type of, even non-linear, functional relations. This approach will also allow the evaluation of reliability also of unique systems and structures as civil and industrial structures, aero motive systems, etc. which could not possibly undergo experimental fault trials but whose reliability is most important for the safety of citizens and workers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Orbem Genus: AI-powered imaging technology for fast, accurate, and contactless object classification & analytics' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Poultry is humanity's most important source of animal protein. Yet, it is extremely difficult to optimize the eggs in - chicks out process, resulting in the waste of billions of eggs, incubation hours, and lives of male chicks. At Orbem we are developing the Genus: AI-powered imaging technology that enables poultry companies to solve their toughest challenges. We use MRI to collect data from inside eggs and process the data with AI to provide access to hidden sources of knowledge. At the pedigree level, breeding companies use the data to develop the next generation of poultry with better quality. At the commercial level, we automatically classify eggs according to different criteria, including fertilization status, inner quality, and the sex of the developing embryos. We can prevent the waste of billions of eggs, dramatically increase hatchability, and stop the culling of male layers - transforming poultry into an efficient, sustainable, and animal-friendly industry.


**Keywords:** Engineering and technology,Magnetic resonance imaging,Digital services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Preparing the Research & Innovation Core for Mission Ocean, Seas & Waters' (PREP4BLUE) under Horizon Europe.

assistant: **Objectives**

Mission Ocean, seas and water aims at restoring the health of our ocean and waters by 2030, as a major contributor to the European Green Deal and the Sustainable Development Goals. Research and innovation will be a key component of the Mission, which will link initiatives across disciplines, mobilise policymakers, stakeholders and citizens, and leverage public and private investments. PREP4BLUE overarching objective is to facilitate a successful first phase (2022-2025) of the Mission, by developing the co-creation and co-implementation R&I modalities required to achieve the Mission objectives and preparing the ground for inspiring and engaging citizens and stakeholders.The project is designed to deliver a series of tools, guidelines, methodologies and recommendations tested through pilots, which will interlink, leverage and optimise activities among the projects funded under the Mission. Our systemic approach will foster cohesion and connectivity between knowledge and technology, funding, regulation, education and skills, social structures and co-creation with R&I actors, citizens and stakeholders.PREP4BLUE multidisciplinary and multi-actor consortium is actively engaged in basin-based strategies and related R&I activities, with strong experience in co-developing business models and recommendations for policy-makers, expertise in social sciences related to participative democracy and citizen engagement and excellent track-record in methodologies for knowledge management and transfer, as well as in stakeholder engagement.PREP4BLUE will also carry out strategic actions to assure the alignment of our CSA with the evolution of the Mission components, including the Mission Core Network, other contributors to the Mission and other Missions. Our project will contribute to prep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biogeomorphodynamic modelling of Estuaries for Management purposes' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Estuaries are important for economy and nature. Due to the relatively calm conditions where land meets the water, they are good locations for harbours and are safe havens and feeding grounds for wildlife. These qualities collide in the Western Scheldt. Dredging is required to enable navigation to Antwerp Harbour, but it endangers the stability of the shoals that are important to ecology. The interactions of the bed and the water flow over it shape the estuaries. The bed determines the flow of the water. In turn the water moves sediment resulting in bed changes. Stability analysis has shown that this feedback mechanism allows free instabilities to grow into a channel-shoal system.The essential processes for the morphology of estuaries are identified, but the long-term dynamics of can only be modelled in idealised cases. Moreover, the problem is more complex. Sediment with much clay is cohesive; sediments with little clay are cohesive. The differences in stability of the sediment strongly influence the shape o f the shoals. Moreover, it has been shown that biology affects the morphology. Some organisms stabilise the bed while others have a destabilising effects. It is unclear yet, how these effects change the morphology of the channels and shoals. Cellular automata a re models that combine the essential mechanisms of a system with the freedom of randomness. The equations describing the essential processes make sure that the correct physics are simulated, while the random element allows free instabilities to grow.In this project the cellular automata approach is used to apply the existing knowledge gained by the stability analysis to existing estuaries. For this purpose the model parameters must be set correctly. Since many of the individual processes cannot be measure d,