RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Industrial Micro Electrochemical Cell sensors for real-time quantification of H2S in wastewater' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Danish SME Unisense A/S has developed an industrial Micro Electrochemical Cell sensor (iMEC) for automatically quantifying dissolved gasses in liquids. In this project, Unisense will optimize their existing handmade sensors, customized for each client, to an auto-calibrated industrial version, targeting wastewater utility companies.In the sewer systems, the prevalence of the toxic H2S gas (sewage gas) causes sewer corrosion and collapse, while at the same time entailing odour nuisances for the population living nearby. The robust iMEC sensor can be installed directly in the sewer network to accurately map H2S contents in real-time, and provide feedback to pumping stations to adjust the chemicals dosed accordingly. This will allow utilities to effectively control H2S levels in wastewater, thereby avoiding corrossion and toxic H2S leaks, and bringing significant economical savings to utilities and municipalities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Socio-economic and spatial impacts of transport infrastructure investments and transport system improvements' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project consists of two subprojects: EUNET and SASIThe work of the two subprojects is brought together by a joint scientific committee.EUNET-subproject main objectives:1. To develop an innovative cost-benefit/multicriteria decision analysis methodology.2. To develop a database of cost models of the transport system.3. To develop a methodology for measurement and valuation of socio-economic development effects and provide values where possible.4. To develop indicators of regional accessibility and social cohesion.5. To develop an operational integrated model of transport and regional development.6. To set up demonstration examples, in which all of the above themes will be drawn together.SASI-subproject main objectives:7. Developing a comprehensive and transferable methodology for the study of socio-economic impacts of European transport system improvements.8. Developing an interactive model with moderate data requirements for the simulation of these improvements.9. Assessing the social and regional impacts of the improvements.10. Demonstrating the model by applying it to case studies. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Early nutrition and long-term consequences on health and disease: an epigenetic approach' to be submitted under Sixth Framework.

assistant: **Abstract**

Human and animal studies suggest that nutritional imbalances occurring during fetal and early postnatal periods can have long-term consequences on health, including obesity and diabetes, and appear to be at least partly caused by changes in genomic expression.Genomes can integrate and translate environmental changes into stable modifications of gene expression by altering epigenetic marks. Epigenetic marks like DNA methylation are particularly important, because they are highly dependent on the availability of methyl donors that are supplied by the diet. Our hypothesis is that the mechanism involved in the long-term effects of nutrition is mediated by changes in the degree of DNA methylation, that in turn, cause permanent changes in gene expression.We propose to determine the genome-wide methylation profiling of liver samples from a mouse model of fetal undernutrition by using microarrays specific for CpG islands, because these are chromosomic regions that are susceptible to methylation and are physically associated to gene regulatory regions. We will also explore the role of diets supplemented with nutrient methyl donors in preventing/attenuating the phenotypes associated with fetal malnutrition.The presence of a link between nutrition, changes in DNA methylation and gene expression can have great clinical relevance, since the possibility of using dietary intervention to maintain the right degree of DNA methylation in order to prevent the deleterious metabolic effects, may become feasible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'DEVELOPMENT OF BIOACTIVE NANOCOMPOSITES FOR BONE TISSUE ENGINEERING APPLICATIONS'.

assistant: **Objectives**

Bone has a remarkable capacity to heal. However, in some instances the amount of bone which is needed to heal exceeds its healing capacity. These cases arise following accidents, infection or surgery to remove cancerous tissue and they result in the need to perform approximately 600,000 surgical bone grafting procedures annually. These procedures have inherent disadvantages and so there is an urgent clinical need to develop a tissue engineering alternative to bone grafting.In this study an osteoconductive/osteoinductive nanoscaffold will be designed to retain growth factors with proven osteogenic potential within their structure. As such, relatively low doses of these expensive molecules can be retained at the bone defect site. The technology developed in this study has enormous potential to reduce the overall burden placed on patients and on European healthcare systems by reducing the costs involved in using Growth Factors in a variety of applications. To perform this work the Fellow will move from Athlone Institute of Technology, Ireland to join a leading orthopaedic research group at one of Harvard University’s teaching hospitals where he will be trained in nanotoxicity testing, detection of growth factor release, cell loading and orthopaedic preclinical models. The Fellow has extensive knowledge in the field of biomaterials and orthopaedic research having trained at the AO Research Institute, Davos, Switzerland. However this fellowship will allow him to develop his knowledge in the field of biocompatibility testing. Knowledge developed in this area will be transferred back to Europe during the return phase of the fellowship. This knowledge will allow the Fellow to further refine the research carried out at Harvard. The goal of this research is to develop translation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel NMDA receptor signaling in cortical synaptic depression' (NovelNMDA).

assistant: **Concept**

Long-term synaptic plasticity is an experience dependent increase or decrease in synaptic signaling between nerve cells that can last from hours to days or even longer. It is thought to represent the cellular substrate of learning and memory by providing an information storage mechanism in the brain. At many excitatory synapses, plasticity-induction processes involve NMDA receptors, glutamate-gated ion channels. I recently discovered a new form of NMDA receptor signaling during spike-timing dependent long-term depression at layer-4-to-layer-2/3 synapses in rodent somatosensory cortex, which requires glutamate binding to the NMDA receptor but not ion flux through its channel. This non-ionic signaling mechanism via the NMDA receptor represents a strikingly overlooked signaling pathway at glutamatergic synapses, and its discovery may overturn much of the long-term depression field, which has focused on calcium influx through the NMDA receptors as the relevant signal in plasticity. Indeed, the discovery of non-ionic NMDA receptor signaling in the postsynaptic membrane even calls into question our current understanding of the basic properties of synaptic signaling. By combining electrophysiology and two-photon imaging and uncaging, we will address the fundamental properties of non-ionic NMDAR dependent plasticity at cortical layer-4-to-layer-2/3 synapses, determine in which synaptic subcompartment plasticity occurs, assess whether signaling depends on a particular NMDA receptor subtype, and examine whether non-ionic NMDA receptor signaling represents a general mechanism at other glutamatergic synapses. This work will lead to a detailed functional understanding of the novel non-ionic NMDA receptor signaling process and its role in synapse function and plasticity.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Feasibility study for clinical validation of an innovative point of care assay for the detection of low-grade-infections in joint replacement' (QuantOnCal).

assistant: **Concept**

About 10-15% of the primary hip and knee arthroplasties have to be revised after surgery. A special case of loosening of implants is the low-grade-infection, which is mostly not recognized and not treated adequately and leads to further revision surgeries and immense impact for the patient. Established markers all failed in the past, in contrast elevated calprotectin and S100A12 levels show a high correlation to low-grade-infections. Immundiagnostik AG developed its own robust smartphone-application based point-of-care assay for measuring calprotectin quantitatively and rapidly without any laboratory. Extending this concept to a calprotectin and S100A12 duplex text low-grade-infections in joint replacement can be detected within minutes for the first time ever. This method will replace time consuming laboratory testing and will help the surgeon to decide in the operation theatre if a two-stage-revision is indicated. Thus health and quality of life for patients is improved and costs for and rate of revision surgery could be reduced significantly. The market size for the new assay and app will be over 60 million Euro in a year. Users of the new diagnosis by will be clinicians in endoprosthesis centres. The innovation will be a quantitative two parameter rapid assay and a smartphone-app as a reader. Two-stage-revision surgery of endoprosthesis as a result of low-grade-infection is a European and worldwide burden. The problem can only be solved in an European consortium to ensure access to European opinion leaders in arthroplasties and to European markets and therefore broad dissemination and exploitation of the project results. Within the feasibility study (phase 1) the following work is intended: Establishing the smart low grade infection assay, patent application, market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European mouse mutant archive non routine working programme i (EMMAWORKS)' (EMMAWORKS) under Fifth Framework.

assistant: **Objectives**

The mouse has become the key model for biomedical and medical research. The European scientific community is internationally competitive in the production and characterisation of mouse models for inherited diseases. However, it is proving to be impossible, for even the largest and best-funded research institutes, to retain all of these animals. It is essential that all mutants that are created are retained and held in a well-organised, central repository-network from which they can readily be made available to interested investigators. To meet these needs the European Mouse Mutant Archive (EMMA) was established and implemented. This application seeks funding for incorporation of significant number of new medically relevant mouse strains. In addition the immediate access to this valuable biological resource for all European countries will be a result of the proposed work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Global positioning of TFIIIC and its involvement in extra-transcriptional processes (ExtraTF)' to be submitted under Seventh Framework.

assistant: **Abstract**

Gene expression is regulated at many levels since changes in the expression pattern of certain genes might lead to the development of diseases such as cancer. Transcription is one of these regulation steps, orchestrated by transcription factors and RNA polymerases. Of these, RNA polymerase III (RNA Pol III) is responsible for transcribing small un-translated RNA molecules, such as tRNA. Transcription Factor (TF) IIIC (TFIIIC) binds to type 2 promoters (consisting of two conserved boxes, A and B), is thought to recruit TFIIIB and subsequently Pol III. Recently, TFIIIC has also been found bound to eight untranscribed B box related sequences, so-called Extra-TFIIIC (ETC) sites, in the absence of TFIIIB and Pol III. Binding of this transcription factor to ETC sites is thought to serve as an anchor point for other proteins, such as proteins involved in chromatin organization and gene silencing.The precise role of TFIIIC in extra transcriptional processes is not clear. The goal of this project is to address this issue by performing in vivo fluorescence cross correlation spectroscopy studies between TFIIIC, ETC sites and other key proteins involved in chromatin organization and transcription. With this method, and by using fluorescently tagged proteins, the interaction between TFIIIC and known and suspected interaction partners will be analysed. In addition, interaction of TFIIIC and ETC sites will be studied, as well as the biological significance of these interactions, by fluorescently tagging the ETC sites. These analyses will be done in a cell cycle dependent manner, to better understand in which cell cycle phase TFIIIC is most important.In summary, this project proposes a global study of the role of TFIIIC in extra-transcriptional processes. Together with biochemical data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding the pan-immune system of bacteria' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The perpetual arms race between bacteria and phage resulted in the evolution of efficient phage-resistance systems. Such systems, including restriction enzymes and CRISPR-Cas, have a major influence on the evolution of both bacteria and phage, and have also proven invaluable as molecular tools. We recently showed that the bacterial immune system is much richer than originally thought. We discovered the CBASS system (Cohen, Nature 2019), prokaryotic viperins (Bernheim, Nature 2020), and additional defense systems widespread in microbes (Doron, Science 2018). These discoveries relied on the observation that defense systems are organized in defense islands - areas in bacterial genomes where multiple defense systems are clustered together. Mining defense islands resulted in the discovery of new defense systems, but our preliminary results suggest that this is just the tip of the iceberg, and that dozens of new defense systems remained undiscovered in microbial defense islands. In this project we will use new genomic approaches, together with analyses of massive genomic and metagenomic datasets, to systematically map the molecular capabilities encoded within the anti-phage “defensome”. The project combines computational genomics, synthetic biology, and deep genetic and biochemical experiments to discover, validate, and study the properties of new defense systems, as well as mechanisms used by phages to mitigate defense. Specific focus will be given to retrons, microbial elements that produce chimeric molecules where RNA and DNA are covalently attached. We discovered that retrons function in anti-phage defense, and plan to decipher the mechanism by which the RNA/DNA hybrid provides defense. Based on the enormous impact that antiviral systems had on modern molecular biology (e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'South-East Europe wind energy exploitation - research and demonstration of wind energy utilisation in complex terrain and under specific local wind systems' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The existing wind potential areas in the former Yugoslav republics (Slovenia, Croatia, Serbia/Montenegro, Bosnia/Herzegovina and Macedonia) are mostly situated in karst regions with steep and cliffy rocks and complex terrain. The prevailing wind conditions at these sites are mainly caused by local wind systems generated by different levels in temperature and air pressure between the Adriatic Sea and the mainland of the bordering countries.Wind farm sites in these areas provide excellent conditions for wind energy utilisation, but also pose a major challenge to wind farm design and wind turbine technology due to extreme wind speeds, turbulences and wind shear. Aim of the proposed R&D project is the performance of investigations at different locations in South East Europe, relating the mountainous and complex structure of terrain, the characterization of local wind systems like Bora" and the more efficient and reliable operation of large scale wind turbine."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ILE DE FRANCE FRENCH EUROPEAN RESEARCHERS' NIGHT: IF I WERE A RESERACHER,...' (IDFFERN) targeting Seventh Framework.

assistant: **Abstract**

Researchers’ Night 2007 in Ile de France (IDFFERN) : if I were e researcher…” aims at giving the opportunity to a large public to meet researchers outside their laboratories. This federative project that brings together 9 partners (local authorities, networks of associations, research structures, SMEs and universities) will result in a festive night all over the territory of the Ile-de-France Region. The project will be linked with other events taking place in France at the same time. The large public will be invited to put themselves in a researcher’s shoes through a variety of captivating activities dedicated to different age categories (children, young and elderly people;..) : scientific theatre, pedagogic activities, demonstrations… The activities have a funny and fascinating side but also raise awareness of the participants on sustainable development of the region and other social issues. They will encourage the idea that every citizen can play an active role in science making. Researchers will be invited to unveil and share their passion with the public in the nice relaxed atmosphere of public gardens, bars and restaurants, theatres and libraries. They will also have the occasion to prove the young public that European research domain offers multiple career possibilities. Several communication channels will be used to disseminate the information all over Ile-de-France (web site, newspapers, radio…). A film will result from the night that will be broadcasted on internet.   Further to the event, the IDFFERN consortium will launch new projects, benefiting from this innovative experience of festive events to raise the interest of the public in scientific issues.