RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigating the joint role of balancing and positive selection in mating systems evolution' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Determining the evolutionary causes of sexual reproduction remains one of the biggest open questions in biology. Investigations of facultative sexuals can shed substantial insight on this subject due to the span of mating systems exhibited, ranging from outcrossing to asexual reproduction. Due to the widespread availability and reduced cost of sequencing technologies, it is now feasible to perform detailed genomic analysis of many individuals, and combine these data with mathematical models to determine how the underlying form of natural selection differs between asexual and sexual individuals. This genomic analysis is essential for providing insight into the evolutionary transitions between different mating systems. We propose to investigate the genetic basis of selection in asexual and sexual organisms, primarily with species of duckweeds (Lemna minor and Landoltia punctata). The initial plan will be to determine the effect of balancing selection on the evolution of recombination and outcrossing rates. Balancing selection is believed to be a widespread force in various eukaryotic genomes, and since loci exhibiting balancing selection tend to be extremely polymorphic, they should strongly influence the evolution of mating systems. After investigating this question using a multi-locus mathematical model, we will create comparative genomic methods by comparing allele and species trees to determine the extent of balancing selection in asexual and sexual organisms. We will then adapt recent mathematical theory on adaptation in selfers and outcrossers to create computational tools for detecting the extent of adaptation from novel and standing mutations, and whether the form of adaptation differs depending on the mating type.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthetic polymers for targeted delivery of genes' under Fourth Framework.

assistant: **Concept**

This project will combine state-of-art synthetic polymer chemistry with cell biology in design and development of efficient vectors for delivery of genes into target cells in vitro and in vivo. This is opportune because the potential usefulness of genetic modification, involving applications ranging from in vitro transfection to clinical gene therapy of human diseases, are now frequently limited by poor efficiency and selectivity of gene delivery and expression. These novel vectors will be completely synthetic, hence they will be fully defined and developed throughout for safety and efficiency. They are designed for generic applicability, self-assembling with any DNA expression vector and capable of incorporating any targeting agent. Ease of scale-up production will make them easy to produce and well suited for routine application in the laboratory as well as clinically for targeted gene therapy of many diseases. This interdisciplinary project represents a coalescence of expertise from cell and molecular biologists and polymer chemists, all with expertise in the field of targeted drug delivery. The best aspects of liposomal and polymer-based delivery systems are combined, designed and developed within the broad context of cellular and molecular biology. The system will be designed for simplicity of application, and the vectors will self-assemble with DNA to permit routine widespread use. Considerable preliminary data are described which establish the feasibility of the approach and suggest the possibility of important progress. The new vectors will be based on soluble synthetic polymers, designed to interact with DNA expression vectors and condense them to a very small size (< 35 nm diameter). The resulting nanoparticles will be packaged within a hydrophilic coating to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Improved management tools for water-limited irrigation: combining ground and satellite information through models'.

assistant: **Concept**

Two EU institutions with 7 institution from 4 Macs will work on improved assessment of the actual consumption of crops under irrigation systems by combining ground and satellite information. Eva-transpiration (ETA) of main crops will be measured on the field with advanced techniques, then used in state of the art process model to develop simple robust method of ETA estimation. Time series of high resolution satellite images will be analysed : a) to determine and measure the actual extension of the main irrigated crops, b) to determine the crop calendar in near real time, c) to apply the robust method to time series of satellite derived crop parameters (such as LAI) to produce maps of ETR and crop water use. A strong interaction with end-users along the project will allow to conceive tools able to implement those results into a follow-up operational phase. Long term sustainability will be ensured through dedicated actions for capacity building and for raising awareness of the beneficiaries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Maintenance of cellular memory by the Arabidopsis VRN1 protein' (VRNEPIGEN) under Seventh Framework.

assistant: **Objectives**

Modifications of a cells chromatin landscape enable cells to memorize and maintain gene expression profiles throughout many cell-cycles during development. In animals and plants the Polycomb Repressive Complex 2 (PRC2) is involved in maintaining genes in an epigenetic “off” state. In mammals and flies a second complex, PRC1, collaborates with PRC2 to maintain silencing. Interestingly, other organisms including worms and plants lack PRC1 and it remains elusive how they achieve stable silencing. In Arabidopsis the DNA-binding protein VRN1 is a potential candidate to fulfil such a role in silencing. During a cold-induced process called vernalization, the floral repressor gene FLC is epigenetically repressed and maintained inactive by a plant PRC2 and VRN1. Lack of VRN1 does not impair PRC2 function but seems to act downstream or in parallel of PRC2, a situation analogous to animal PRC1. Moreover, as found for mammalian PRC1, VRN1 interacts with a component of the spliceosome complex, implying RNA processing in Polycomb silencing. The above findings suggest that VRN1, despite its lack of homology with PRC1 components, functions in the stable maintenance of PRC2 mediated silencing. My aim is to establish a solid foundation for a mechanistic understanding of VRN1 mediated gene silencing using vernalization as a model. In-depth VRN1 protein-complex analysis will be complemented by chromatin and RNA immuno-precipitations (ChIP and RIP) as well as theoretical modelling of the vernalization process. Besides addressing a long-standing question in plant epigenetics, collected data will allow comparison with the situation in non-plant systems to develop a mechanistic consensus model on maintenance of gene silencing in different kingdoms. Notably, for both plants and humans, fundamen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Future Experiments seek Smart Technologies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Future Experiments (FE) in Particle Physics face new challenges both in terms of large areas and high rates. Extended R&D activities on existing detectors such as GEM, MicroMegas, micro-RWell, silicon detectors, large volume drift chambers, as well as detectors still to be fully developed like Dual Readout Calorimeters, are the ingredients to build any experiment at future accelerators (as CepC, FCC, ILC or Muon Collider).The very large scales of future detectors require new and improved production techniques. Their industrialization would allow for: a plethora of non-academic applications such as homeland security, monitoring devices as well as medical imaging applications; a better production yield and a reduced construction time; a significant cost reduction. This is one of the main goals of our intersectorial activities within the Project.FE will face unprecedented experimental conditions, with strong magnetic fields and extremely high luminosities. New Front End Electronics (FEE), and new digitization, clustering and tracking algorithms must be developed and optimized. An ideal playground for such processes is the BESIII Cylindrical GEM Inner Tracker (CGEM-IT) that is being built and will be installed at IHEP, Beijing, by mid of Reporting Period 2. This will be the first time that a GEM is operated in a 1 T magnetic field being readout in micro-TPC mode and exploiting the TIGER, a fully custom ASIC for MPGD readout.Another aim of the project is to develop a new generation of general purpose ASICs, capable of interfacing with several different detector types. FEST also aims to perform MonteCarlo simulations of FE, improving and updating event generators to the new experimental scenarios. All these activities require a large computing power. A possible approach invol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Physics-informed Data-driven Analysis for Wind Power Hubs' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

To address the challenges of climate change and energy crisis, the European Union (EU) is accelerating the transition to carbon neutrality, using wind power as the key driver. To fully exploit EUs offshore wind resources, the strategy of constructing wind power hub has been devised recently and will be implemented in the North Sea. However, integration of numerous power converters in wind power hub forms a sophisticated system, making analysis difficult. This project (PhyDAWN) will tackle these challenges by developing physics-informed data-driven modelling and stability assessment methodologies for wind power hub. Firstly, effective impedance model of voltage source converters for varying operation points will be developed based on physics-informed machine learning. Next, a scalable aggregated model for wind power hub will be proposed using transfer learning, improving modelling effectiveness under insufficient data. Then, the stability of wind power hub will be assessed in a probabilistic manner, realizing intensive stability analysis for internal converters. A software toolbox will also be developed for fully exploitation of the research results in the industry. The applicant has expertise in data-driven grid analysis. During the project, she will collaborate with the supervisor at Aalborg University, who has rich research experience on power converter modelling and analysis. Besides, she will collaborate with the secondment supervisor at KTH Royal Institute of Technology, who is an expert of control theory. Through these collaborations, PhyDAWN will create novel knowledge for wind power hubs, and also strengthen the applicants career prospects. The research results will be disseminated by publications in top journals and conferences, producing a positive impact on r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Algorithms, Design Methods, and Many-Core Execution Platform for Low-Power Massive Data-Rate Video and Image Processing' to be submitted under Seventh Framework.

assistant: **Abstract**

ALMARVI aims at providing cross-domain many-core platform solution, system software stack, tool chain, and adaptive algorithms that will enable massive data-rate image/video processing with high energy efficiency. ALMARVI will provide mechanisms and support for high degree of adaptivity at various system layers that will abstract the variations in the underlying platforms (e.g., due to imperfections in the fabrication process), communication channels (e.g., available bandwidth), application behaviour (dynamic workloads, changing requirements) from the application developer. This is crucial for providing consistent performance efficiency in an interoperable manner when considering heterogeneous platform options and dynamic operating conditions. The key is to leverage image/video content-specific properties, application-specific features, and inherent resilience properties of image/video processing applications.The goal of ALMARVI is to develop:• Adaptive, scalable, and parallelised algorithms for image and video processing• Cross-domain system software stack with adaptive run-time system for efficient resource/power management and improved interoperability• Concepts for continuous hardware and software adaptations• Cross-domain many-core execution platform scalable with off-the-shelf heterogeneous acceleration fabrics like FPGAs, embedded GPUs, DSPs, etc.• Design tools and methods for execution platform• Industrial-grade demonstrators for multiple application use cases to validate the project results.APPROVED by ARTEMIS-JU 19/12/2016 (amendment nr 2)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Network for Habitat Monitoring by Airborne-supported Field work – An innovative and effective process in implementation of the Habitat Directive'.

assistant: **Innovation**

The aim of CHANGEHABITATS 2 is the initiation of a long lasting intersectoral and international network in the field of environmental monitoring between industry and academia. Its aim is to develop operable, time and cost effective procedures, and (software) solutions for monitoring habitats using innovative airborne data acquisition techniques. Within the project two complementary data acquisition methods which are currently becoming established in the market will be concentrated on: airborne laser scanning and airborne hyperspectral imagery. These methods will be evaluated and their potential for manual and automatic derivation of habitat parameters – an unsolved problem so far – will be investigated for selected sites. Added value of the developed methods beyond habitat mapping will be explored, e.g. for river basin management.These aims will be achieved by tight integration of data producers, data processors and end users, building the network both from industry and academia. The project will support EU´s NATURA2000 Directive, which prescribes repeated monitoring of over 50 million ha of habitat sites in Europe. The complexity and importance of habitat monitoring by airborne techniques will ensure close cooperation within the network beyond the project duration.Cost savings in an order of up to 3.4 Billion Euros at European level could be achieved by reducing expensive and laborious field work for habitat mapping by automated analysis of airborne sensed data, which is cheaper in acquisition and more homogeneous than subjective perception during the field work. The contributing SMEs will gain economic benefits and clear competitive advantages. For device manufacturers a new market for data acquisition devices will be opened, and for service providers faster and more
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Age-related arterial dysfunction and gut dysbiosis in mice and cetaceans' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Cardiovascular disease (CVD) is the number one cause of death in Europe. Arterial dysfunction develops with aging making advancing age the primary risk factor for CVD. Advancing age can induce adverse changes in the gut microbiome, which in turn, can activate systemic pro-oxidant and pro-inflammatory signaling pathways with detrimental downstream consequences. One main objective of this project is to investigate the role of the gut microbiome in modulating arterial function with aging. To approach this objective, I will carry out two experimental studies: 1) mouse-to mouse transplant of gut microbiota to investigate if gut microbiota transfers vascular phenotypes. This experiment will show if gut microbiota modulates arterial function with aging, and will provide insight into the mechanisms involved. 2) Germ-free mice with microbiota samples from human subjects to determine the contribution of the human microbiome to a particular phenotype. Cetaceans are long-lived mammals and excellent divers. They undergo constant cycles of tissue hypoxia-reoxygenation and shear stress caused by vascular adjustments while diving. In humans, these adjustments produce an elevation of oxidative stress and inflammation markers and impairment of the endothelial function. Thus, another main objective of this proposal is to explore if cetaceans, i.e. whales and dolphins, have developed an endothelium-protective mechanism to prevent arterial dysfunction with age and diving. To approach this objective I will study vascular function, circulating oxidative stress and inflammation markers, and gut microbiome of cetaceans of different ages in captivity as well as stranded animals.The objectives to investigate the role of the gut microbiome in modulating arterial function with aging will be carried
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'European Universities designing the horizons of sustainability'.

assistant: **Objectives**

Sustainable Horizon Alliance will contribute to an inclusive society, supporting researchers/academics deeply thinking, respecting nature, practical problem-solving professionals, adapting to new challenges. We are six young HEIs, open to innovation, located in small cities within EU periphery, from South Extreme (Faro-Pt, Huelva-Es), Central (Zlìn-Cz, Ludwigshafen-De), Eastern (Timisoara-Ro) to North (Lahti-Fi) carried out activities of co-production with relevant economic regional impact. The complementary strength in sustainability scientific fields aiming at inclusive institutional transformation and providing a platform as preferential partners collaborating with surrounding ecosystems. The goals are to support the Alliance created in 2019 and in especially the Widening Countries HEIs (UAlg, BUAS UTB) to, within the network and with the best practices, define road maps to effectively implement inclusive approaches to open science policies, gender balance plans, careers management, researcher’s societal links. Our sustainability research approach will be anchors on traditional sciences (environmental, socioeconomics) but with strong interdisciplinarity innovation based on Artificial Intelligence, allowing Entrepreneurship and Employability to impact regional ecosystems. The Alliance will rely on a creative governance model with a balanced top-down and bottom-up approach with the academic/researcher clusters (Science & Technology, Health, Socio-Economics), the leadership (Rectors& Directors), to an effective institutional change that will achieve balance between careers and life, to foster a variety of joint research projects based on excellence and trustful collaboration to allow International competitiveness. Using our HEIs geographic proximity, historic, cultural