RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Alzheimer’s disease and AAV9: Use of a virus-based delivery system for vectored immunoprophylaxis in dementia.' under Horizon 2020.

assistant: **Concept**

Alzheimer’s disease (AD) is the most common form of dementia in the Western World, representing an economic and social cost of billions of euros a year. Given the changing demographics of society, these costs will only increase over the coming decades.Amyloid plaques, composed of amyloid beta peptide (Abeta), are a defining characteristic of AD. Evidence now suggests that Abeta is central to disease pathogenesis due to its toxicity, which leads to cell loss and eventual cognitive decline. Abeta is generated by proteolytic cleavage of amyloid precursor protein, a process that involves the protein BACE1.Knock-down of BACE1 is sufficient to prevent amyloid pathology and cognitive deficits in transgenic mouse models of AD, so BACE1 is an attractive target for therapeutic intervention. Although many small molecule inhibitors of BACE1 have been developed, many have problems with imperfect selectivity, posing a substantial risk for off-target toxicity in vivo. In contrast, antibody-based therapeutics provide an attractive alternative given their excellent molecular selectivity. However, the success of antibody therapies in AD is limited by the blood brain barrier, which limits antibody entry into the brain from the systemic circulation.Recent studies have shown that adeno-associated virus serotype 9 (AAV9) effectively crosses the blood brain barrier. Here, we propose evaluating the use of AAV9 as a delivery system for a highly specific and potent inhibitory nanobody targeted against BACE1 as a treatment for AD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Construction of a resource protein database for the arabidopsis plasma membrane' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The objective of this proposal is to develop new tools for the functional identification of new plant genes. It aims at assigning genes to identified proteins In a first step, we propose to focus on a particular set of proteins and choose the plant plasma membrane proteins because (i) functional studies of this interface between the cell interior and external medium are at the forefront of plant cell biology, (ii) less than 5 % of the total number of plasma membrane proteins are represented within databases, and (iii) it will be a challenge to fill this gap in our knowledge by systematic generation of sequence information on plasma membrane proteins and respective DNA sequences. This information must be generated and stored in a centrally available database to provide an important resource for researchers from both academia and industry. We propose a coordinated effort to construct a fundamental database on Arabidopsis plasma membrane proteins, connecting protein expression and sequence information to available or new EST data. Our action will be based on: the construction of a comprehensive directory of plasma membrane proteins (by 2D PAGE) - the generation of partial amino acid sequence data - the development of new methodologies allowing both to identify rare plasma membrane proteins (by using an original expression cloning procedure) and to assign protein sequence data to partial DNA sequences available in EST databases (by using an innovative gene chips methodology) and the construction of a database accessible either directly or through cross referred existing databases. A first part of the work involving most partners will concern, beside an effort for the standardization of procedures, (i) the analysis of plasma membrane protein expression patterns in various Ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interaction phenomena in novel materials' in the context of a Seventh Framework call.

assistant: **Objectives**

Recent progress in electronics has largely been associated with controlled fabrication of low-dimensional nanostructures, so there is much interest in the transport, materials, photonic and plasmonic properties of small electronic nanodevices. Further  technological breakthrough is expected by implementing novel materials such as magnetic semiconductors, carbon-based nanostructures and materials with strong spin-orbit coupling. Among a number of potential candidates for basic elements of future nanotechnology, graphene and topological insulators occupy a worthy place. Several established researchers with complementary experience unite in the project to tackle the key challenges in understanding intriguing interaction phenomena in new materials. Within this project we focus on transport and magnetortansport properties of graphene, graphene plasma-wave THz electronics, and interaction- and disorder-induced effects in topological insulators. We will uncover new physics originating in the inter-band transitions in these materials and demonstrate how to take advantage of new physical phenomena in making electronic and optical devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Starting Grant' under Horizon Europe.

assistant: **Concept**

Efficient anticancer immune effects are a prime medical discovery of this century. Molecular alarms drive such immune responses, signaling priming and effector cells to action. Several approaches are studied or clinically used to initiate or support such action. Yet, the perhaps evolutionary old and most conserved mechanism has been mostly off the map so far: reactive oxygen species (Physical-technical applications extend into medicine for diagnostics and also therapies, such as: cancer treatment. Tumor cells present various receptors on the cell surface, and immune cells can interact with these receptors to decide whether a cell should be eliminated or not. Therapies or other external influences can change the spectrum of the presented receptors and thus the interaction, aiming to stimulate an immune response. Once a tumor cell gets identified as harmful, an immune response is initiated to recruit cytotoxic T cells and other adaptive immune cells to reduce tumor growth. Physical plasmas are therapeutic and have antimicrobial efficacy and cancer-killing effects. Plasmas can be generated to operate at low temperatures, which enables them for medical applications, and produced reactive oxygen and nitrogen species (ROS) mainly induce biomedical effects. In tumor cells, plasma treatment leads to redox stress, followed by altered surface marker expression, which has immune-stimulating properties. However, ROS are not absent when the tumor cell dies, and further ROS-mediated mechanisms, such as oxidation of released biomolecules, continue. I hypothesize that immune-stimulatory properties of plasma are combinatory effects of molecular changes and biomolecule oxidation, suggesting that a standardized plasma treatment with maximized ROS, more precisely radical production, optimi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Implementations of topological quantum computation' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

It is difficult to build quantum computers because it is hard to isolate and to control quantum objects with sufficient precision. I study new ways of quantum control, which can be more robust and can implement elementary steps in quantum computers with greater precision.The techniques I use are based on topological phenomena. Topology is an area of mathematics that studies properties of objects that remain invariant under smooth deformations. In my case I study properties of quantum objects that remain in variant under small perturbation.This means, for example, that even if the shape, intensity or frequency of laser pulses, which control the evolution of trapped atoms, fluctuate we can still induce a desired modification of atomic states.Moreover, this can be done in complex systems involving many atoms. In particular I plan to investigate how topological quantum phenomena can be implemented in optical lattices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MilkTeeth: a biogeochemical investigation of ancient weaning and dairy Milk consumption using human Teeth' (MilkTeeth) targeting Horizon 2020.

assistant: **Abstract**

Milk is at the centre of two great archaeological debates, with resonance today; infant weaning and dairy food consumption. Weaning timing has implications for infant health and mortality, and is strongly influenced by culture. While there are records of cultural ideas regarding infant nursing in the past, where historical accounts are not available or are of questionable accuracy, much remains a mystery. Archaeological studies of dairy consumption have also become part of the debate regarding costs/benefits of dairy in modern diets. Individual life histories can answer questions about milk use within populations, and population trends provide insights into milk consumption within larger social and cultural contexts. MilkTeeth is a pioneering, multidisciplinary, international action combining techniques to better address questions of weaning and dairy consumption in the archaeological record, providing greater understanding of both individual and cultural relationships with milk and dairy foods, and informing modern dietary debate. MilkTeeth will use traditional techniques from bioarchaeology (carbon, nitrogen and oxygen isotope analysis) and novel techniques from (bio)geochemistry (calcium and strontium isotope analysis) and proteomics (detection of the dairy specific whey protein β-lactoglobulin), and will have unique access to a Synchrotron Light Source beamline for Tender-Energy Spectroscopy (diagenetic assessment and mineralisation processes) to detect direct evidence of milk consumption using human teeth. It will bring together researchers from the UK and USA with expertise in ancient human milk consumption, bioarchaology, archaeology, instrumental chemistry, (bio)geochemistry, protein analysis and particle physics. By combining these traditional and novel techniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'European Network of Excellence on Photonic Integrated Components and Circuits'.

assistant: **Objectives**

The leading thread of this NoE is photonic integration. The integration of complex or high performance photonic functions will become the key enabler for a cost-effective and ubiquitous deployment of photonics in a wide range of applications, including ICT, sensors and biomedical applications. The technologies needed for photonic integrated components and circuits are characterised by high investment and exploitation cost. This calls for more integration of research at an international level. Therefore the mission of ePIXnet is three-fold. The first objective is to stimulate the restructuring of the photonic integration research community from a model of independent or collaborative research towards a model of integrated research. The second is to stimulate training activities as well as integration of educational programs. The third objective is to stimulate new opportunities for photonic integration in a wide range of application domains.The NoE will contribute to the strategic objective: Optical, opto-electronic, photonic functional components and will focus on five major themes: photonic integration technology, nanophotonics, advanced semiconductor materials, ultrafast light sources and ultrafast signal processing. The network brings together most of Europe's strongest academic and industrial actors and will contribute to the quality of education and research by stimulating long lasting partnerships and by providing access to unique facilities and knowledge in the field. To this end the steering committee has selected 5 specific Facility Access Activities and 9 specific Joint Research Activities on the basis of their potential for research integration. The network will also develop an active program of exchange of researchers, of institutional collaboration agreemen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Validation and Optimization of an Open-Source Novel Nonlinear Froude-Krylov Model for Advanced Design of Wave Energy Converters' (OpenWave).

assistant: **Innovation**

Wave energy represents a great untapped potential, but modern technologies are not economically viable yet, mainly due to high investment risk and modelling uncertainties during design/development stages. Accurate and computationally fast mathematical models are essential tools for effectively and reliably designing wave energy converters (WECs). Although WEC dynamics are typically very nonlinear, linear (imprecise) models are extensively used due to their computational convenience; in contrast, nonlinear models currently available are more accurate but too slow for design optimisation or control applications. This fellowship purports to develop, validate, and disseminate a novel class of nonlinear models, which will realise an unprecedented pairing of accuracy and computational speed (100 to 1000 times faster than homologous existing models). Conversely to other, slower nonlinear models, this novel model can facilitate effective design and optimisation of the device, enable real-time power optimisation and model-based control. The project will greatly impact the wave energy community, making a high-performance modelling tool easily accessible to any stakeholder for a variety of advanced design purposes. This project is comprised of 3 work packages, which accomplish: (1) validation of the model for axisymmetric devices, (2) expansion and validation of the model for pitching platform devices, and (3) enhancement of computation performance and release of an open-source software. In addition, this fellowship will expand the career horizons of the fellow: a highly multidisciplinary plan is defined, building upon and extending beyond his current competencies. The fellow is well-positioned to undertake this project, allowing him to fully develop innovative ideas from his PhD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Quantification of mixing and dynamic uncertainty for transport in heterogeneous porous media' (MixUQ).

assistant: **Innovation**

Natural and engineered porous systems exhibit heterogeneity across several spatial scales leading to complex flow fields with strong fluctuations. The latter enhance the segregation and distortion of a transported scalar mixture, while diffusion promotes the local homogenization of it. In this context, spreading has been traditionally identified with the overall growth of the dissolved plume while mixing with the internal plume homogenization. Accurate quantification of mixing in heterogeneous media is one of the most relevant and still open challenges. Our current failure lay in the inability of capturing the interplay between flow fluctuations and local diffusion: the former promotes both the internal plume segregation (at early times, dominance of pure advection) and the subsequent homogenization (at late times; dominance of dispersion) by the sampling of flow fluctuations which trigger the internal folding and distortion of the plume enabling local homogenization by diffusion (coalescence mechanism).  We here propose to predict mixing within a unified framework (Work package 1) which leverage on the Lamellar description of transport and capture the early (segregation) and late (coalescence) time impact of fluctuations by viewing spreading as a sub-plume scale process: the dispersion and interactions of Lamellae are captured through a continuous time random walk (CTRW) approach.  At the same time, uncertainty about concentration distribution is a dynamic quantity ruled by the same physical mechanisms:  plume segregation (uncertainty production) and homogenization (uncertainty reduction). We here take advantage of the insight from the novel transport model to close evolution equations (e.g., for the variance and the probability density function) apt to describe the dy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Learning and Development of CONTextual ACTion' in the context of a Sixth Framework call.

assistant: **Objectives**

By spontaneously generating and also observing/imitating manipulative gestures, infants quickly learn how to interact with their environment. At the same time, communicative abilities develop leading to a more complex use of speech.Are these motor abilities developing independently? Or are there fundamentally similar mechanisms in the development of perception and production, for both speech and manipulation?We believe that the latter is the case. This project represents an ambitious attempt to investigate the parallel development of manipulatory and speech gestures from a multi-disciplinary perspective. Experts in Robotics, Neuroscience, and Child-Development will collaborate to build an embodied artifact, which will develop its motor capabilities both in manipulation and speech.The hypothesis deals with a scientific finding indicating that actions are represented more in terms of goals then in terms of procedures. This finding brings to a possible unified theory underlying both manipulation and speech, apart from obvious differences relative to effectors and sensory modalities involved. Moreover, action representations can be addressed not only during execution but also by the perception of action-related stimuli. Consequently, production and perception will be investigated at the same time. The focus will be, therefore, on a combined Perception-Production model that develops incrementally, finally leading to a system that learns to:Perceive and produce simple manipulatory gestures and wordsInfer the goal of gestures, and meaning of words.Our approach will give us the possibility to experimentally manipulate the development process on the basis of the experiments and theories reached by the Neuroscience partners. At the same time, theoretical questions and implementat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Promoting gender equality in research institutions and the integration of the gender dimension in research contents' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Despite more and more solid indicators, extensive research, policy initiatives at European and national levels, and wide awareness-raising on the issues linked to gender and science, the European Research Area is still confronted to structural obstacles within its research institutions which prevent the ERA from reaching its objectives on the full participation of women in research and innovation at all levels (while women comprise >50% of PhD graduates, they still occupy less than 20% of Grade A positions) as well as to a lack of integration of the gender dimension in research contents and programmes which hinders their quality and potential for innovation.With the aim of collectively addressing these issues, the GENDER-NET ERA-NET proposal brings together national ministries and research programme owners and managers from 11 countries with synergistic expertise in gender issues in research. Partners will join forces to: 1) map and analyse existing national/regional programmes and initiatives aimed at a) promoting gender equality in research and higher education institutions through structural change, b) gendering research contents; 2) identify priority activities for strategic transnational implementation; 3) design and optimise transnational transferability; 4) implement these joint activities. GENDER-NET thus consists of 4 work packages which build on one another to propose a pilot transnational research policy initiative which will allow for a global vision of the best practices and conditions for success, innovative assessment and knowledge-transfer methods, as well as concrete engagement of partners in the implementation of joint activities, thus breaking new ground at EU-level and contributing to the realisation of ERA. Expanding outcomes by relying on the share