RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Particle Resolving Fluid-Sediment Interaction', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Climate change leads to increased frequency and magnitude of flash flood events in rivers and of storm surges in coastal areas. Flash floods are associated with larger discharges and water levels, whereas storm surges are characterized by higher wave heights and water levels. These events have significant consequences for both rivers and coastlines triggering a morphodynamic response. Resulting erosion and soil mechanical failures can result in severe damage to civil infrastructure and buildings. There is a knowledge gap that connects the hydraulic, hydrodynamic and geotechnical aspects of environmental loading due to current, wave action as well as sediment and soil response respectively. With the increased likelihood of extreme weather events, there is an urgent need to study coastal morphology and mitigation approaches from a multi-disciplinary physics-based perspective.Representing the interconnected processes of current, waves, sediment transport and soil deformation constitutes an interdisciplinary challenge. In the current project, particle based sediment transport models are created that take a significant step towards a realistic representation of these processes. The missing link between the individual modules will be developed, bridging the confinements of the disciplines of hydraulic, coastal and geotechnical engineering with heavy use of advanced computational fluid and solid mechanics. The multi-scale nature of extreme hydrodynamic events and their interaction with sediment and soil particle physics will be solved through a holistic multi-scale numerical framework. The proposed research lays the foundation for taking a significant step in sediment transport research that is required for dealing with current and future challenges arising from climate change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural studies of the full-length human Vitamin C transporters: unravelling Vitamin C transport across the membrane' (VitC) targeting Horizon 2020.

assistant: **Abstract**

SVCTs are Sodium-dependent Vitamin C Transporters, part of the large solute carrier protein family (SLC), and are the major carriers for Vitamin C uptake and regulation. Abnormal Vitamin C regulation has been associated with several diseases, including cancer, obesity, hypertension, autoimmune and neurodegenerative diseases. Furthermore, Vitamin C attenuates oxidative stress caused by alcohol consumption while continuous Vitamin C deficiency leads to scurvy. Despite their importance, Vitamin C uptake and regulation are poorly understood.In humans, SVCTs include two important classes, SVCT1 and SVCT2, that belong to a family of membrane-embedded, phosphorylation-dependent glycoproteins with an overall 65% sequence identity. Specifically, SVCT1 is expressed on the epithelia of hepatic, intestinal and renal tissues, presenting low affinity and high capacity for Vitamin C, having an important role in regulation of whole body homeostasis. SVCT2, on the other hand, exhibits high affinity and low capacity, and is expressed in most cells and tissues where its function is the delivery of Vitamin C to cells as a cofactor for major enzyme pathways protecting from oxidative stress. To date, the structural basis for the mechanism of action of SVCTs remains largely unexplored.Here, we aim at unraveling the mechanism of Vitamin C transport and regulation by determining the three-dimensional structures of both SVCT1 and SVCT2, thereby providing mechanistic understanding of the different activities of these transporters. We will use a multidisciplinary approach of high-resolution cryo-electron microscopy (Cryo-EM), X-ray crystallography and biophysical methods to understand SVCT function and interactions. This work will contribute to elucidating the mechanism of Vitamin C transport by S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Small scale farmers’ sustainable adaptation strategies to climate change based on ecosystem services'.

assistant: **Concept**

ADAFARM aims to analyze ecosystem-based climate adaptation options and nature based solutions for small farmers in sub-Saharan Africa. In line with the SDGS these strategies would be economically efficient, environmentally sustainable and socially equitable. I will use a social-ecological frame to focus on the role played by formal and informal institutions and key factors like poverty and gender for ecosystem based adaptation strategies to climate change.I will build on data, results and stakeholder networks from the ACES project. ACES was a 3 year research project, funded by the UK government (2 M. €) with the aim of analyzing the consequences from the loss of ecosystem services from deforestation to the livelihoods of poor rural communities. I will further analyze data from a survey done to more than 1600 households, with new lenses: the adaptation of small scale farmers (especially women headed households) to climate change and in particular the role of institutions. To complete the research, I will perform new qualitative data collection, through interviews and focus groups, to complete our understanding of the climate change adaptation options for small scale farmers.I am currently working at ICATALIST, an innovative SME specialized in knowledge brokerage, applied research and capacity building related to socio-ecological systems and adaptation to climate change. Working at ICATALIST will allow me to eventually transfer and scale the project to other areas with real and plausible interventions to design and help implement adaptation strategies to improve the resilience of small scale farmers. ICATALIST aims to play a leading role in the climate change adaptation policy space, with viable financing solutions for development (and thus the SDGs). This project will pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring the Terauniverse with the LHC, Astrophysics and Cosmology' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The visible matter in the Universe is well described by the Standard Model, but this leaves open major questions in both particle physics and cosmology that may be answered by new physics at the Tera-electron-Volt range: the Terascale. The Large Hadron Collider (LHC) will soon open a new stage in humanity’s direct exploration of the fundamental physical laws at Terascale energies, which governed the evolution of the Universe a fraction of a second after the Big Bang, and are essential for understanding high-energy astrophysics. In addition to unraveling the intimate structure of matter at the Terascale, e.g., by discovering the source of particle masses and exploring matter-antimatter asymmetry, the LHC will address key cosmological issues such as how dark and conventional matter originated, which may well have been at the Terascale, and the nature of the primordial plasma that filled the Universe. This proposal will lead the understanding whatever new physics the LHC may reveal, incorporating insights from cosmology, high-energy astrophysics and speculative ideas such as string theory. This interdisciplinary approach will also facilitate the application of knowledge acquired from the LHC to fundamental cosmological and astrophysical problems, as well as illuminate future collider priorities, e.g., for LHC upgrades and/or a linear collider. This proposal will bring together particle theorists, experimentalists, astroparticle physicists and experts on field and string theory in the framework of a new ‘London Centre for Terauniverse Studies’. This will provide new opportunities for students and other young researchers to get directly involved in making LHC discoveries and exploring their implications for the Universe, and provide a mechanism for transferring to them inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Dark Energy Imprint on the Baryon Acoustic Oscillations'.

assistant: **Innovation**

This work programme addresses pressing issues in both observational and theoretical cosmology. The main goal is to use the Baryon Acoustic Scale of Oscillations (BAO) to pin down the nature of the Dark Energy (DE) component.The BAO scale is a powerful probe of DE properties. It constrains geometrical as well as dynamical tracers of the Universe’s evolution, and can break the long-standing degeneracy between dark energy and spatial curvature.The observational component is strongly related to data analysis of the SDSS survey the most successful of astronomical surveys in history, in particular the BOSS survey that Dr. Cortes is a part of. It is also related to the design and conceptual planning of BOSS’s next-generation experiment, the GROUND-BASED SPECTROSCOPIC BigBOSS survey that Dr. Cortes is also a part of.BigBOSS is currently being planned at Dr. Cortês’ institution, Lawrence Berkeley National Laboratory and will extend the studies of BOSS to even earlier stages in the history of the universe, leveraging the full power of BAO to the next level.The theoretical component will play an essential role in ensuring the design of future probes of DE is optimized to obtain the best leverage of future data in the constraining of DE models.This work constitutes a breakthrough in the way BAO data, in particular from the Lyman-Alpha Forest, is currently treated and converted in constraints on DE.The goal of the project is to promote the transfer of expertise of analysis of BAO data between the US and the European Union, through the EDINBURGH INSTITUTE FOR ASTRONOMY.It is also highly beneficial for European Science Community as a whole to exchange expertize in survey planning with the US, in consultation with community-led teams to define the optimal survey with a broad and rich s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An innovative, non-invasive and de-risked system to enable the transdermal delivery of fragile therapeutic compounds for a better management of painful diseases' (NANO-GROWTH), addressing dissemination and exploitation.

assistant: **Impact**

Chronic pain affects +1.5 billion people worldwide, which means that pain affects more people than diabetes, heart disease and cancer combined. Since chronic pain persists for years, it becomes unbearable. Chronic pain is often the result from neuropathy (nerve damage), which increases with age but also due to chronic diseases. For instance, 34% of diabetes cases develop painful neuropathy, which means 143 million people affected globally. Since there is no cure, patients receive analgesics and other meds for pain relief. To avoid inflicting further pain, medication is administered transdermally using topical solutions like creams or patches. However, there are important barriers to the dermal delivery of analgesics: scarcity of viable compounds, high biodegradation rate, short effect, poor efficiency and severe adverse effects. In response, we at Astracime have developed an innovative solution that overcomes the limitations of transdermal pain relief. This NANO-GROWTH project aims to bring to market a unique dermal patch loaded with encapsulated therapeutic compounds. The customized capsule protects the integrity of the compounds as they travel through the skin layers and bloodstream. In addition, we have engineered the capsule to provide target-mediated release. Altogether, our method secures a longer and safer pain relief. After been proven at the lab scale, we now aim to take a step further towards the mature stage. Thus, in Phase 1 we aim to assess the subsequent steps needed to secure this project from all technical, commercial and financial perspectives. This project encloses significant growth potential for Astracime, allowing us to consolidate a leader position in the field of pain management. Indeed, we expect to gain €41 million in revenues and hire 30 new pe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of RNA-guided genome editing in eukaryotes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The goal of this project is to contribute to our understanding of RNA-mediated epigenetic mechanisms of genome regulation in eukaryotes. Ciliated protozoa offer a fantastic opportunity to investigate the complex process of trans-generational programming of chromosomal rearrangements, which is thought to serve as a form of immune defense against invasive DNA. Developmental processes in ciliates include extensive rearrangements of the germline DNA, including elimination of transposons and the precise excision of numerous single-copy elements derived from transposons. This process is considered to be maternally controlled because the maternal genome provides essential information in the form of RNA that determines the offspring's genome content and organization. This programmed DNA subtraction, the so-called ‘RNA scanning’ process, is mediated by trans-generational comparison between the germline and the maternal somatic genome. One of the most intriguing questions is how a complex population of small RNAs representing the entire germline genome can be compared to the entire rearranged maternal genome, resulting in the efficient selection of germline-specific RNAs, which are able to target DNA deletions in the developing genome. All this occurs in a very short time and involves a massively coordinated transport of all the components between three types of nuclei. This project focuses on characterizing the molecular machinery that can orchestrate the massive genome rearrangements in ciliates through nucleic acids and protein interactions. It also addresses the question how RNA targets DNA cleavage at the right place. In addition, this project aims to investigate the role of RNA in guiding chromosomal rearrangements in other eukaryotic systems, particularly in human cancer c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'To Care Or To Kill: When The Needs Of The Many Outweigh The Needs Of The Few.' to be submitted under Horizon Europe.

assistant: **Abstract**

As epitomized by epidemics and pandemics throughout human history, including the ongoing SARS CoV-2 pandemic, social life carries risks of substantial and rapid spread of infectious diseases. Termites living in pathogen-rich environments have evolved remarkably robust social immunity mitigation strategies that effectively prevent diseases from spreading within colonies. Individual termites carefully balance whether to care for a sick nestmate and save the colony worker resources, or kill the sick nestmate to remove the risk of an infection spreading. The behavioural and immunological factors driving this dichotomy remain obscure. The CareKill action will close major gaps in our understanding the role of pathogen dose and infection stage in governing the switch from care to kill, what genes are involved in decision-making (immune pathways, neural networks, genes involved in stress), and how behavioural and immune memory impact care-kill decision making during subsequent encounters with sick nestmates. The action will capitalise on my extensive background in behavioural ecology and social immunity in termites, and integrate state-of-the-art pathogen load quantification and global gene expression analyses on actively caretaking or killing focal termites to establish if social immune memory is key to effective long-term reduction of disease risks. In doing so, this work explores novel concepts and hypotheses to close important gaps in our understanding of social immunity. CareKill will benefit from synergies of ongoing chemical ecology research in the focal termite species by my host, Michael Poulsen (University of Copenhagen), who will provide training in combining molecular techniques and termite ecology. CareKill will provide fundamental novel insights into the adaptive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spatial organization and Horizontal gene transfer of Antibiotic Resistance by ESBL in WasteWater' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The tidal increase of clinical antibiotic resistance is of serious threat to public health and should be viewed in an integrated system influenced by the environmental dimension of antibiotic (AB) resistance. This innovative proposal intends to address the current knowledge gaps concerning the biofilm spatial organization and interspecies interactions that underlie the antibiotic resistance strategy by extended spectrum β-lactamase (ESBL) producing bacteria thriving in wastewater treatment plants (WWTPs). The proposal has 3 objectives: Obj.1) Evaluate the impact of interspecies interaction of ESBL gene sharing by conjugation in the biofilm collective AB resistance and its interdependence with bacterial spatial organization; Obj. 2) Evaluate the interspecies interactions concerning the cephalosporin resistance at a functional level by following the expression and localization of ESBL and other AB resistance related proteins; Obj. 3) Evaluate the potential of WWTP as hotspots for AB resistance by assessing the sharing of ESBL genes and their expression. Such objectives will be achieved by the implementation of 3 work packages that address each one in a stepwise approach with the use of state-of-the-art techniques, based upon the most up to date references. European Commission (EC) have declared antimicrobial resistance as an important global economic and a societal challenge, that must be tackled by a multi-sectorial approach, where the environmental sector is included. The SHARE_WW project will make important advances in the field of β-lactam AB resistance proliferation and environmental spread, by covering several scientific gaps referred in the most up to date literature. In line with the multi-sectorial EC approach, the results from this project will have great releva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GRAvitational N-body Dynamics:Dynamics and evolution of multiple planetary systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The discovery of hundreds of exoplanets in the last decades have revolutionized the field of planetary astrophysics.  The properties of many of these systems turned out to be quite peculiar and very different from our own Solar system;  they gave rise to outstanding puzzles and opened new avenues for  processes involved in planet formation and evolution. In our own Solar systems the last decades have brought the discovery of binary planetesimals, new minor planets in the trans-Neptunian regime and many new planetary satellites. Taken together, these new horizons open the path for major breakthroughs in our exploration of planet formation, dynamics and evolution. I propose to study multiple systems in the planetary regime, where dynamical processes can play an important role, both through strong scatterings and collisions as well as through secular processes, and strong interactions with the environment. At the small scales I will explore the role of binary planetesimals  in planet formation and their evolution; these are important both for the early stages of planet formation in general, as well as for the long term evolution of planetesimals in our own Solar system and their observed properties. At a larger scale, I would explore planetary satellites, suggesting that dynamical scattering processes studied in the context of multiple exo-planet systems could play a similar role in the structuring of satellites systems and the origin of irregular satellites, and potentially exo-moons. Finally, I propose an extended research program about multiple exo-planet systems, focusing on their size/mass ordering characteristics, and making use of these yest unexplored properties to learn about the underlying physical processes involved in their assemblage. The study of these variou