RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TERPENOYLATION: AN ORIGINAL CONCEPT FOR THE DISCOVERY OF NEW NANOMEDICINES' (TERNANOMED), addressing dissemination and exploitation.

assistant: **Impact**

Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evolutionary control technology for sustainable thermal processes (ECOTHERM)' (ECOTHERM) targeting Fifth Framework.

assistant: **Abstract**

Optimisation of the process control of a solid waste incinerator can contribute to minimize the emissions (CO, NOx, CO2) , to maximize the waste throughput and to reduce the waste processing costs of the plant. This project has the objectives to design, develop and test new advanced control concepts for waste incinerators based upon new intelligent sensors. The main problem of controlling a waste incinerator is the continually changing waste composition. In this project a recent developed on-line sensor for the calorific value of the waste will be used. This sensor will be combined with an optical sensor in a total control concept. Two approaches will be followed to develop the new control concepts: one based on first principles (short-term) and the other on genetic-evolution principles (long-term). A prototype which merges these concepts into an optimal control concept will be built and tested at two plants in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High Performance Transport Network Modelling and Simulation' (HIPERTRANS).

assistant: **Innovation**

Making better use of the exisiting infrastructure is one of the major objectives of the Common Transport Policy. The main problem involved is the large amount of data that has to be treated within a short period of time. To improve this situation and to provide road network operators with an efficient tool, the HIPERTRANS project will develop an accurate, high-speed, and visually interactive simulator for a road transportation network within a high-performance computing (HPC) environment. The simulator will be capable of interfacing, in real time, with urban traffic control (UTC) systems. It will be able to forecast the behaviour of a road network. The simulator will enable industrial end-users associated with the project, including road transport network operators to assess the performance of a road network quickly under a variety of operational conditions and behavourial patterns. It will also provide a tool for road traffic control systems commissioning and operator training, and for the specification, analysis, design, commissioning and operation of urban transportation networks prior to the implementation of new networks and strategies, or the modification of existing ones. The simulator is expected to be used in evaluating strategies to reduce traffic congestion levels (and consequent air pollution problems).Links with other projects, tasks, areas, programmes, policy actions:Links with Trans-European Road Network and Infrastructure PolicyCase studiesSpecific sites to be identified in the course of the project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nutrient and water relations of short-rotation forest tree species - the role of mycorrhizal root symbioses' in the context of a Fifth Framework call.

assistant: **Objectives**

The applicant will be trained in state-of-the-art stable isotope techniques and their application in plant physiological research. The co-operation with researchers at the host institution will broaden the applicants research experience especially in the fields of plant water relations and soil nitrogen transformations. Experience in supervisory skills will be gained through direct involvement in PhD and graduate research projects, and in undergraduate teaching. The expertise in mycorrhizal research of the applicant will be useful to researchers at the host institution in a number of ongoing projects on microbial nutrient turnover in forest soils and on plant rhizodeposition and soil biological aspects of sustainable agriculture. Additionally, the experience of the applicant will be used in teaching through the involvement of the applicant in undergraduate courses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Information theoretic analysis of brain function' under Fourth Framework.

assistant: **Concept**

Research objectives and content My Fellowship proposal consists in the development and use of information theoretic techniques to understand how information is represented by neurons in the cerebral cortex. To this purpose, I will develop methods for a rigorous measure of the information encoded in neuronal spike trains. I have already published original results on this subject for single neurons. The aim of my Fellowship is to develop new techniques for analyzing the information contained ib the firing of populations of neurons, by working in a laboratory in which the neurophysiological data are being obtained. I will apply these methods to new data, obtained in the host lab, consisting of the activity of neurons recorded in three different cortical areas of primates (IT cortex, Hippocampus, and Orbitofrontal Cortex). The main objective is the understanding of i) how information is encoded by single neurons responding to natural time-varying stimuli ii) how populations of cortical neurons represent information; iii) how much information is carried by neurons, when compared to the maximal information that can be conveyed under the same constraints (i.e. the study of the efficiency of the representation). This study will allow a better understanding of how the representation of information in different brain regions is adapted to the task each performs, since the analysis will be systematically applied to different cortical networks performing different functions. Training content (objective, benefit and expected impact) The impact of this training for my career will be decisive. In fact Oxford is a place in Europe which can guarantee the presence of very good Departments of Experimental Psychology, Theoretical Physics and a Centre for Cognitive Neuroscience. I will need
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Vacuum forming as low-cost production method for high-quality products' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The target in the proposed project is to develop vacuum forming as a low cost production process for continuous fibre reinforced thermoplastic products. Three groups of companies will benefit from this development: 1) companies that work with unreinforced thermoplastics, 2) the ones that work with reinforced thermoplastics and 3) the ones that work with reinforced thermo sets. The innovative aspect of this project is to combine the advantages of the vacuum forming process with the advantages of continuous fibre reinforced materials. The process in view aims at combining the short production times and low pressures associated with the vacuum forming process with the high stiffness and strengths resulting form the use of fibre reinforced thermoplastics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flexible Tube Micro Plasma (FμTP) for Dried Blood Spot (DBS) analysis' to be submitted under Horizon 2020.

assistant: **Abstract**

The need and importance of newborn screening (NBS) is a reality in most of the western countries. NBS helps with the detection and prevention of important health issues during neonates first days of life, avoiding growth or mental retardation or even potential deaths. Even when each individual disorder has a low incidence into the population, their cumulative occurrence is relatively high, around 1 in 1,500 to 1 in 5,000. Most of the NBS programs in western countries are well established but there is a constant need for new methodologies that can tackle more efficient, cheaper, faster, and simpler ways to analyze different disorders. SPOTplasma will help to address innovative methodologies for NBS. Firstly, the project will tackle the idea of unaltered NBS sample analysis with no sample or minimal preparation steps considered as a kind of “Holy grail” for precious samples. And secondly, during SPOTplasma a platform based on ion mobility spectrometry (IMS) will be investigated as an alternative for newborn screening in developing countries, barely implemented due to the lack of well-equipped infrastructures in their public system along with the high costs associated with MS instrumentation. In conclusion, SPOTplasma will address dried blood spot (DBS) analysis by developing analytical tools that can speed up the screening process or cheapen the analysis. Novel methodologies based on a flexible Tube Micro Plasma (FμTP) coupled to mass spectrometry (MS) and stand-alone IMS are proposed for DBS analysis not only for NBS but also in the pharmacological industry.


**Keywords:** Newborn Screening, Dried Blood Spots
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Synthetic lectins for beta-GlcNAc: evaluation of their potential biological applications towards O-GlcNAc-modified proteins'.

assistant: **Innovation**

Lectins are carbohydrate-binding proteins which play many roles in nature, and are important also as tools for biological research. For example, they are used to make fluorescent reagents which bind to, and thus identify, particular carbohydrate units, and also to make separation media which distinguish between differently glycosylated biomolecules. An important target for such reagents/media is beta-GlcNAc on serine or threonine (the O-GlcNAc protein modification). This moiety has been implicated in many biological processes and human diseases such as diabetes and neurobiological disorders. The lectins used to bind O-GlcNAc do not perform especially well, and the host group have shown that, remarkably, a designed “synthetic lectin” may be superior. The aim of the project is to explore this possibility, developing and testing biological tools (e.g. stains and separation media) based on the synthetic system. The research will involve international collaboration with five laboratories, two in Europe (Madrid and Leuven) and three in the US. The applicant will move from Spain to Bristol (UK) to carry out this research, while undergoing training in a variety of scientific and complementary skills (including during visits to two collaborating laboratories). The applicant plans a scientific career at the interface between supramolecular chemistry and biology (biosupramolecular chemistry). The project will expand his synthetic, organic and supramolecular chemical knowledge, introduce him to certain biological techniques (e.g. Western blotting, affinity chromatography and biological NMR), and encourage him to develop his independent scientific ideas. At the end of the Fellowship he will be well-positioned to apply for independent positions in the ERA. If successful, his research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Russia’s interventions in conflicts of the Middle East and Africa: Local perspectives on a Russian emerging model of conflict management' to be submitted under Horizon Europe.

assistant: **Abstract**

RuMEA aims to analyse Russia’s interventions in recent conflicts of the Middle East and Africa (MEA), exploring their interaction with local political contexts. Russia approaches these crises through a mix of hard power, coercive diplomacy, and economic activism, guided by the principle of non-interference with these regions’ authoritarian regressions. As such, it provides local leaders with a model of conflict management that differs radically from liberal-oriented approaches that dominated international customs in the post-Cold War era. But what explains local preferences for ‘the Russian model’? This project adopts a dual perspective to analyse (1) the Russian model’s distinctive features and (2) explain its appeal to countries on the ‘receiving end’ of Russia’s political intervention, advancing debates in Russian and Middle Eastern/African studies. It utilises a diverse set of methodologies to deepen specific aspects of Russia’s engagement in the MEA, including elite interviews (to assess local preferences), media content analysis (to understand public discourse), and archival investigation (to document Russia’s long-dated experiences of dealing with regional crises – Cold War and the 1990s – which may offer insights into contemporary practices). These are the gaps I intend to address with this research project, which lies at the intersection of Area Studies, International Relations (IR), and International History. RuMEA builds upon methodological skills I gained during my previous experiences as a historian working on Soviet-Arab relations while taking my research trajectory into new directions. The Fellowship will be based at Harvard University (Kennedy School, HKS) and Ca’ Foscari University of Venice (UNIVE), and includes secondments at the University of Oxford
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design and synthesis of new electroluminescent metal complexes for improved disease diagnosis' under Fourth Framework.

assistant: **Concept**

Research objectives and content The aim of the project is to design and synthesise new metal complexes with high sensitivity in electrochemiluminescence detection. A new class of metal complexes with high emission quantum yield and different redox properties will be synthesised choosing appropriate substituents and varying the metal ion. The new compounds will be investigated with electrochemical methods and in electrochemiluminescence. Then, appropriate molecules will be made available with reactive functional groups (labels) for conjugation to biomolecules (Proteins, peptides, nucleic acids, haptens). The conjugates will be further evaluated as substitutes in routine assay, e.g. HIV, progesterone, DNA analysis. Training content (objective, benefit and expected impact) The proposed project will train the candidate in organic synthesis, electrochemical and biochemical methods and applications in immunoassays and DNA testing. This research will have a lot of impact on the carrer prospects of the candidate, broadening her knowledge in different topies, acquiring new skills and industrial experience. Links with industry / industrial relevance (22) The project would be carried out in the research laboratories of an industry and would investigate new systems and improve products already in the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Robots with animal-like resilience' under Horizon 2020.

assistant: **Concept**

Despite over 50 years of research in robotics, most existing robots are far from being as resilient as the simplest animals: they are fragile machines that easily stop functioning in difficult conditions. The goal of this proposal is to radically change this situation by providing the algorithmic foundations for low-cost robots that can autonomously recover from unforeseen damages in a few minutes. The current approach to fault tolerance is inherited from safety-critical systems (e.g. spaceships or nuclear plants). It is inappropriate for low-cost autonomous robots because it relies on diagnostic procedures, which require expensive proprioceptive sensors, and contingency plans, which cannot cover all the possible situations that an autonomous robot can encounter. It is here contended that trial-and-error learning algorithms provide an alternate approach that does not require diagnostic, nor pre-defined contingency plans. In this project, we will develop and study a novel family of such learning algorithms that make it possible for autonomous robots to quickly discover compensatory behaviors. We will thus shed a new light on one of the most fundamental questions of robotics: how can a robot be as adaptive as an animal? The techniques developed in this project will substantially increase the lifespan of robots without increasing their cost and open new research avenues for adaptive machines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A citizen context aware platform to provide mobile public services' (MPGS), addressing dissemination and exploitation.

assistant: **Impact**

"This proposal relates to the necessary evolution of public services, leveraging the potential of ICT technologies, towards users’ increasing expectations about ubiquitous access, ease of use, friendliness, efficiency, security, transparency and participation in government decision making. Public services transformation will foster the interaction of citizens and businesses with public administrations.Our overall innovation project consists of a user-centric platform for the creation of user experience enhanced mobile public services, in order to improve the provision of public services and foster their utilization by citizens and businesses. The integration of mobile contextual information network creation platform, SMARTINDOOR, and a gamification platform, GAMILEKU, will contribute to motivate users to utilize public services and participate in government decision making, SMARTLEKU.""""