RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The humoral innate immune system: long pentraxins as a paradigm' in the context of a Seventh Framework call.

assistant: **Objectives**

The innate immune system consists of humoral and a cellular arm, but attention has largely been focused on cells and their receptors. The humoral innate immune system (HIIS) is generally represented as  a collection of diverse molecules (collectins, ficolins, pentraxins). A tenet underlying this application is that in spite of molecular diversity, the HIIS is built on general principles and logic conserved in evolution. This general view will be put to a test capitalizing on the discovery by the applicant of the long pentraxin family, the prototype of which is PTX3.   PTX3 is a multifunctional fluid phase pattern recognition receptor, highly conserved in evolution, at the interface between innate immunity/ inflammation and female fertility /matrix remodelling. The specific aims of the  studies outlined herein are:1) better define the repertoire of HIIS receptors by identifying new receptor(s) (eg PTX4) and ligands as well as interaction among receptor families (eg Ficolins); 2) pursue the structure and function of PTX3 as well as of newly discovered related molecules;  3) using genetic and cellular approaches define the relative importance of different cellular sources (eg lymphatic tissue); 4) based on 1-3,  address fundamental mechanisms and logic in the interplay between cellular and humoral innate immunity; 5) explore the applicative potential of long pentraxins as diagnostics; 6) based on 1), engineer new pentraxins as potential therapeutics. The focus will largely be on unexpected turns, based on preliminary results, including: coupling of members belonging to different molecular classes; mechanisms of regulation of innate immunity (pathways of complement activation; P-selectin and leukocyte trafficking);  the role in the extracellular matrix of lymphatic vessels.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiphase flow training site' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Fellowships are offered on research related to multiphase flows in industrial processes. European doctorals are invited to join the integrated research groups at NTNU (Norwegian University of Science and Technology ) and SINTEF (SINTEF Petroleum Research ) in Trondheim, Norway, and take part in research activities covering both fundamental and applied aspects on multiphase flows. The form of activities range from experimental work, mathematical modeling and numerical simulation. The experimental work will be conducted at the NTNU laboratories and at SINTEF Multiphase Flow Laboratory (SIMLab ). SIMLab is the EU designated Research Infrastructure for multiphase flow in Europe. Particular challenging current fields of research are multiphase CFD (computational fluid dynamics), transient multiphase flows, particle flows and heat and mass transfer processes. The Norwegian University of Science and Technology (NTNU) is the national center for technological education and research within the natural sciences. NTNU and SINTEF, the largest independent research institute in Scandinavia, collaborate closely on a wide range of research fields. Most of the research projects are conducted in partnership with the petroleum industry. Marie Curie Fellows will join integrated NTNU-SINTEF research teams and have available all services from both institutions, including social services, university courses, computer networks, application software and high quality laboratory facilities and technical assistance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Host Templates for Nanoelectronic Functional Guests' in the context of a Seventh Framework call.

assistant: **Objectives**

The TEMPLATES project aims at constructing highly organised lattices consisting of a nanoporous structural host template in which functional guest moieties can be accommodated, and to address these with electrochemical scanning probe techniques.  The guest species are metal nanocrystals in the quantum confinement size range and redox molecules, both capable of active electronic function (switching, amplification, rectification) in an electrochemical environment.  Our strategy focuses on electrolyte gating at electrified solid/liquid interfaces, which can address physical gates down to 1 nm by achieving strong electronic coupling, and allows the target ""device"" to function under ambient conditions.  By varying the guest–guest distance, the electrolyte (including ionic liquids) and the operational conditions, we aim to demonstrate cooperative and gating medium effects, and long-term stability and functionality.  The host–guest network could be used as high-density non-volatile memory or perform logic functions in nanoelectronic devices, and therefore has a high application potential.In addition to its challenging technical goals, the TEMPLATES project offers high potential of professional reintegration of the applicant.  The research project capitalises on the results, scientific and complementary skills that the applicant acquired during the initial Marie Curie Fellowship, while maximising the benefits offered by the research environment of the new host institution, with a strong focus on knowledge transfer.  In doing so, it is envisaged that the project will strongly catalyse the applicant’s successful progress to an independent leading research position in the near future.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Phosphoinositide-lipid signaling in neuronal mitochondrial biogenesis'.

assistant: **Concept**

Mitochondrial dysfunction leads to several neurodegenerative diseases and is implicated in neuropsychiatric disorders, yet our understanding of how mitochondrial biogenesis is tailored to neurons is very limited. My identification of a role for the phosphatidylinositol-(4,5)bisphosphate (PIP2) phosphatase SYNJ2 in local mitochondrial biogenesis connects phospholipid signalling with mitochondrial maintenance and mitophagy in axons. My lab is already utilizing advanced imaging methods to study RNA transport and local mitochondrial biogenesis. Recent advances in local lipid perturbations now make it possible to also identify lipid-mediated regulatory mechanisms of mitochondrial biogenesis.This project spans all the way from mitochondrial biochemistry and signaling mechanisms to neuronal cell biology and local translation, culminating in how the molecular effects alter mouse physiology and behavior. We have preliminary evidence that PIP lipids are involved in the regulation of RNA tethering and local translation. This occurs at mitochondria-endosome contacts, which are enriched in PIP lipids. Likewise, contact sites between mitochondria and late-Golgi or lysosomes provide PIP lipids during mitochondrial fission, yet both organelles are rare in axons. SYNJ2a, which is a neuron-enriched splice variant, could underlie the special morphology of axonal mitochondria and contribute to axonal mitochondrial fission. Finally, PIP altering drugs are used for the treatment of mood disorders, and mitochondria and mitophagy have come recently into the spotlight for their role in neuropsychiatric disorders. Alteration of local mitochondrial biogenesis via altered PIP levels may provide a mechanistic link between mitochondria and mood disorders. MitoPIP will be of significance to patients
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrating SOil Biodiversity to Ecosystem Services: testing cost-effectiveness of Soil Biodiversity indicators and the provision of soil biodiversity-based Ecosystem Services to build better land management solutions that effectively implement the EU Soil Strategy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The aim of the EU Soil Strategy is that by 2050 all soils in the EU are healthy. However, cost-effective indicators for soil biodiversity, ecosystem functioning and ecosystem services are missing, and so are cost-effective measures for restoring soil health. SOB4ES will contribute to the Mission A Soil Deal for Europe by: (1) elucidating soil biodiversity, ecosystem functioning and services for major land uses and land use intensity changes; (2) testing cost-effectiveness of existing indicators for soil biodiversity, ecosystem functioning and services; and, (3) evaluating how policy incentives may enhance protection, sustainable management and restoration of soil systems and soil health. By focusing on nine major pedoclimatic (soil type-climate) regions and land uses, including soils from urban, agriculture, forest, (semi)-natural, wetlands, drylands, industrial and mining environments, SOB4ES will cover most relevant EU climate-soil type-land use conditions. SOB4ES will further develop the mapping and assessment of ecosystem conditions (MAES) approach. For agricultural land uses, envisaged sustainable agricultural practices will be compared with conventional high input-output practices. Ultimately, SOB4Es will deliver well-validated and applicable indicators for soil biodiversity and ecosystem services for policy evaluation to be used in EU-wide soil health monitoring from the field to the landscape level. SOB4ES will also analyse how networks of soil biodiversity relate to aboveground biodiversity and ecosystem services by advanced artificial intelligence-based machine learning approaches, and scale monitoring up to being applied by remote sensing. Finally, SOB4ES will support a more effective adoption of indicators by large-scale European surveys, such as LUCAS and S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'HPC/Exascale Centre of Excellence in Personalised Medicine - PerMedCoE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Personalised Medicine (PerMed) opens unexplored frontiers to treat diseases at the individual level combining clinical and omics information. However, the performances of the current simulation software are still insufficient to tackle medical problems such as tumour evolution or patient-specific treatments. The challenge is to develop a sustainable roadmap to scale-up the essential software for the cell-level simulation to the new European HPC/Exascale systems. Simulation of cellular mechanistic models are essential for the translation of omic data to medical relevant actions and these should be accessible to the end-users in the appropriate environment of the PerMed-specific big confidential data.The goal of the HPC/Exascale Centre of Excellence in Personalised Medicine (PerMedCoE) is to provide an efficient and sustainable entry point to the HPC/Exascale-upgraded methodology to translate omics analyses into actionable models of cellular functions of medical relevance. It will accomplish so by 1) optimising four core applications for cell-level simulations to the new pre-exascale platforms; 2) integrating PerMed into the new European HPC/Exascale ecosystem, by offering access to HPC/Exascale-adapted and optimised software; 3) running a comprehensive set of PerMed use cases; & 4) building the basis for the sustainability of the PerMedCoE by coordinating PerMed and HPC communities, and reaching out to industrial and academic end-users, with use cases, training, expertise, and best practices.The PerMedCoE cell-level simulations will fill the gap between the molecular- and organ-level simulations from the CompBioMed and BioExcel CoEs with which this proposal is aligned at different levels. It will connect methods’ developers with HPC, HTC and HPDA experts (at POP and HiDA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Looking for Emotions in the Absence of Sight' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Affective abilities are crucial for social interactions, as understanding, predicting and responding to emotional signals is necessary for the optimal functioning of daily life. Of note, emotion recognition relies on the detection of salient information, a task chiefly accomplished through vision. As a matter of fact, affective signals are largely conveyed through nonverbal communication, and can be perceived exclusively through sight, as the redness on the cheeks when feeling embarrassed. Indeed, previous behavioral evidence and functional brain data point to the crucial role of sight in emotional processing. Therefore, a question naturally arises: how emotions are experienced/perceived in absence of vision? Specifically, how do congenitally blind individuals describe emotions through language? Is their representation of affective states in the body different from a sighted subject? Do they retain the same mechanisms of emotional coding in the brain? To answer these questions, the proposal (1) will explore the emotion ontology of sighted and congenitally blind individuals, revealing to what extent emotion semantics develops independently from the sense of vision; (2) will study how much the representation of emotional bodily sensations depends on sight; (3) will investigate whether the stream of affect is differently encoded in the brain of sighted and blind individuals. The action will adopt an interdisciplinary approach, exploiting methods ranging from computational linguistics to psychological assessment, as well as from behavioral to neuroimaging investigations. The innovative framework here proposed will advance our knowledge of sensory deprivation and emotion by mapping affective states in language, body and brain. Importantly, the current action will highlight f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Empirical evidence on the formation of habits, self-control and non-separabilities in food choices' (FOODHABITS), addressing dissemination and exploitation.

assistant: **Impact**

The proposed research aims to improve our understanding of individual choices over which foods to purchase. The research aims to make fundamental contributions to models of choice and preference formation, and the outputs will inform the development of policy interventions that seek to improve nutritional outcomes. Our particular interest will be to better understand: (i) the importance of the foods available at home in childhood in influencing choices that young adults make over which foods to eat, (ii) the relevance of temptation and self-control in explaining poor nutritional food choices, and the ways that advertising might influence these behaviours, and (iii) the important interactions that exist between the ways that people spend their time (for example work and physical activity) and the food choices that they make and how this determines nutritional outcomes. A proper understanding of the way that preferences are formed, and the ways that they might be influenced, is key to the design of effective public policy. The food market is a good place to study these questions for a number of reasons. First, people make decisions with high frequency and in different economic conditions, which helps provide variation needed for identification of key parameters of interest. Second, we observe the same individuals making choices both for immediate consumption and for future consumption, which will also help us with identification. Third, the food industry is of considerable policy interest. People in developed countries are getting fatter at an alarming rate. To the extent that people do not take account of the effects of this on themselves in the future and on others then they are making suboptimal decisions; they and society could potentially be made better off by policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Olfactory processing of repellent and attractive stimuli in the brain of Drosophila' (OPRAS).

assistant: **Concept**

Mosquito-borne diseases present one of the greatest threats to human health. Mosquitoes find humans by detecting human body odour and CO2 with their olfactory system. This project addresses the fundamental and still unresolved question of how odorant valence is coded in the brain and why odorants that are attractive (positive valence) at low concentrations, switch to being repulsive (negative valence) at high concentrations. This phenomenon of valence switch is well conserved throughout the animal kingdom and represents an ideal paradigm to address a key question in the neurosciences, i.e. how information processing in neuronal networks leads to behavioural responses. To advance the understanding of valence coding and olfactory processing, the Experienced Researcher (ER) will capitalise on her detailed knowledge of the evolutionary well conserved olfactory system of the fruitfly Drosophila melanogaster, using its powerful genetic and experimental approaches (e.g. Riabinina et al, 2015, Nature Methods; Gao et al, 2015, Nature Neuroscience). The key goal of the project is to identify patterns of neuronal activity that code for odorant valence. To achieve this goal, we will record responses of small subsets of genetically labelled second-order olfactory neurons by patch-clamp while activating olfactory receptor neurons optogenetically or by odorants of known behavioural valence. We will apply statistical and machine learning techniques to detect parameters of neuronal activity, indicative of odorant valence. This project is significant for three reasons. First, it will dramatically improve our understanding of the mechanisms of olfactory processing likely applicable across species. Second, it will create new genetic reagents and experimental solutions, widely applicable ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Studying the potential of mutations induced by microbial genotoxins to induce colorectal cancer' (MutaMicrobes).

assistant: **Concept**

The increasing incidence of early-onset colorectal cancer (EO-CRC) points to an unknown, possibly preventable, cause. A strong candidate is the gut microbiome. Experimental studies show certain bacterial strains can affect CRC onset, potentially by producing genotoxins that induce cancer-driving mutations. Our project aims to test this hypothesis. We have identified colibactin, a genotoxin produced by certain E. coli strains, which leaves a specific mutation pattern (SBS88) found in both healthy colon cells and in about 12% of CRC tumors. Another similar mutation pattern, SBS89, also appears to be acquired early in life, but its cause is unknown. Our two main objectives are to: Identify mutational patterns induced by microbial genotoxins by systematically screening them in human intestinal organoids and comparing the results to large cancer databases. Secondly, we aim to determine the role of these mutations in driving cancer by performing transformation screens in organoids, identifying how genotoxins can initiate cancer and lead to mutations in key driver genes. This research will help explain rising EO-CRC rates, identify individuals at risk, and guide future preventive strategies. Our team has extensive expertise in organoid research, genomic analysis, and the study of colibactin-induced mutations, making us uniquely qualified to address this critical public health issue.


**Keywords:** Bacterial toxins, Microbiome, Carcinogenesis, Mutagenesis, DNA damage