RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of cost-effective tools for risk management and traceability systems for marine biotoxins in seafood (BIOTOX)' in the context of a Sixth Framework call.

assistant: **Objectives**

The proposed multi-disciplinary project will focus on the development, validation, and standardisation ofreference methods (LC-MS) and cost-effective assays for the identification and quantification of lipophilic marinebiotoxins, which have been included in the European legislation, and for which currently no methods exist.Existing knowledge on functional and biochemical assays will be used. Application of the Biacore SPR biosensortechnology will be applied to establish high throughput analyses. The new methods should lead to replacementof the existing animal tests. A validation study of the developed tests and a feasibility study on the production ofCRMs will be carried out according to international validation protocols. Early warning systems, based on geneexpression and passive samplers will be developed. The second part of this project will focus on measurementsto be taken after the outbreak of a harmful algal bloom, including improvement of decontamination techniquesand implementation of traceability systems. A report on the harmonisation of monitoring, control, traceability, andhandling of shellfish in EU member states will be prepared. An expert panel will guide and help to avoid overlapwith work elsewhere. Links with other EU projects (SHELLFISH, SEAFOODplus and BioCop) will be establishedto strengthen research. Contacts with the CEN and the IRMM (Joint Research Centre) will be established toobtain advice on standardisation and CRM production. The following key deliverables will be produced: assaysfor all lipophilic toxins included in European Directives, SPR technology for high throughput analysis; a referencemethod; an early warning system based on gene expression and/or passive sampling; recommendations on thecertification of reference materials; improved dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum algorithms and the foundations of quantum computation' (QAQC).

assistant: **Concept**

Quantum computing (and, more broadly, quantum information science) is a new area at the frontier of both computer science and physics. The laws of quantum mechanics are profoundly different from conventional physics. Quantum computing studies how to use them for the purposes of computer science and information processing. Quantum computing (and, more broadly, quantum infromation science) has seen tremendous progress in the last 15 years, both on its theoretical side (with Shor's quantum algorithm for factoring and Grover's quantum search algorithm) and experimental side (with small scale prototypes for quantum computers and commercially available systems for quantum cryptography). We plan to address the following questions: - What problems can we solve on a quantum computer (besides factoring and search)? More generally, can we isolate general principles for designing quantum algorithms? - What are the problems that {\em cannot} be solved by a quantum computer? Which of the conventionally hard problems remain hard, even if quantum computers are available? - What are the fundamental properties of quantum states and what insights do they provide for quantum computing? In particular, we plan to study randomness and pseudorandomness in the quantum world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of patient “Ossicle” for the personalized modelling of bone-developing cancers and therapeutic testing' under Horizon Europe.

assistant: **Concept**

Cancer is a huge societal concern representing one death out of sixth in 2020. The vast majority of existing cancers emerge or ultimately develop in bones: leukemia, lung, breast, prostate, kidney, bladder. Our bones are thus considered a privileged harbor for cancer cells, and this is also associated with a very poor survival prognostic: bone-developing cancers account for ~3 million deaths each year. When at all existing, treatments are poorly effective: 92% of new therapies successful in preclinical testing fail in clinical trials. This urgently calls for the development of models to study cancer and test therapeutics in a more reliable fashion. Towards this objective, we proposed to engineer human mini-bones in mice, in order to mimic the patient bone-developing cancer condition. These mini-bones (aka human ossicles) forming in animals consists in miniaturized bone organs composed of the patient own cells, including cancer cells. The human ossicles were thus proposed as unique technology to study tumour progression but also test therapeutics in an advanced and personalized in vivo setting. However, despite substantial promises, the human ossicle model suffers from a lack of standardization: only 10% of patient-derived cells can successfully form human ossicle5. This prevents the large exploitation of hOss as a standard model to study bone-developing cancers and establish tailored treatments.We here propose OssiGel as a technology offering the standardized and reproducible formation of human ossicles. OssiGel consists in a cell-secreted gel, which production is ensured by a dedicated human cell line. Mixing isolated patient cells with OssiGel in vitro restore their capacity to form human ossicle. By injecting the OssiGel/patient-cells mixture in the back of mice lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PI3K isoform specific functions in the nucleus', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

During my Marie Curie fellowship, I have found that the p110d PI 3-kinase (PI3K) selectively regulates the cell migration and proliferation of mouse macrophages and I have delineated the signalling pathway by which p110d regulates these responses. In particular, the CSF-1-induced signalling found to be mainly controlled by p110d due to its unexpected preferential recruitment to the CSF-1 receptor.Interestingly, RhoA activity was found to be selectively controlled by p110d and to be the key molecule that regulates both, proliferation (through PTEN) and migration. I have also obtained evidence for a new pathway of interplay between cytoskeletal regulation and cell cycle, with an unexpected potential role for PI3K in the nucleus. It is the latter aspect that I propose for my return grant application.The aim of the proposed return project is to delineate the role of the PI3K isoforms in the nucleus and to establish a potential PI3K isoform-specific controlled pathway that links nuclear with cytosolic signalling in the context of the Rho small GTPase proteins.More specifically, the objectives of the present project are:- Characterization of expression and function of the nuclear PI3K isoforms in macrophages carrying mutant class IA PI3Ks.- Investigation of a potential PI3K isoform specific PTEN-dependent regulation of Akt phosphorylation in the nucleus.- Investigation of a potential PI3K-isoform specific regulation of cross-talk between CKIs and Rho GTPases- Investigation of the mechanism that controls the translocation of p110s into the nucleus and identification of the nuclear import/export sequences in the p110s sequence.This reintegration grant will assist me to carry out work in this subject area as an independent researcher upon my return to my country of origin (Greec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'eLTER EnRich - Bridging phases towards the Integrated European Long-Term Ecosystem, critical zone and socio-ecological Research Infrastructure' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

eLTER EnRich aims at catalysing the eLTER ESFRI process towards a successful conclusion, balancing between (1) the changed framework conditions since 2020 and (2) the vision and role in the European system of Research Infrastructures (RIs) identified by ESFRI. This role is to enable frontier research for a sound understanding of ecosystem change or adaptation in response to multiple global change pressures/pulses, thus providing an essential tool for achieving the Sustainable Development Goals and the Green Deal, and for the transition to a sustainable and resilient Europe.Given the current 'force majeure' factors, the RI cannot be implemented in the linear process originally planned, but in a phased approach that requires agile planning tools to support scenario assessment and prioritisation in close interaction with our stakeholders. To this end, EnRich is implementing a model-based systems engineering approach to better capture the complexity of the distributed RI and to support dynamic decision making towards a research infrastructure capacity that is well co-ordinated across ~20 formally involved countries. The eLTER System Architecture (SA) allows us to design a baseline 'Skeleton RI' with well selected initial key services as a starting point for incremental extensions during the operational phase. Cyberinfrastructure components of highest relevance for the eLTER service portfolio will be driven from the SA and implemented in close collaboration with related projects and RIs. Formalisation efforts will be intensified to achieve sustainable commitment from service hosts and future ERIC members, despite the current global uncertainties. This will ensure a seamless transition from eLTER projects to eLTER ERIC operations, build capacity in terms of expertise and huma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enhancing the innovation management capacities of SMEs in West Poland' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The objective of the project is to contribute to and enhance the innovation potential and innovation management skills within the SMEs in the West Poland area. The project will follow a developed methodology to help the regional businesses to increase their innovation capacity and to innovate profitably.The project will be implemented via 2 specific schemes:1) Service ‘Key account management for SME Instrument beneficiaries’.This service will be aimed at SMEs which will be successful in applying for the SME Instrument Programme under the Horizon 2020 (Phase I or Phase II). Upon the receipt of the information (potential beneficiary’s contact details) from the EC/EASME, the project partner will contact the potential beneficiary in order to explain the service and convince the SME to use the potential it offers.2) Service: ‘Enhancing the innovation management capacity of SME’s’.This service will be aimed at promising SMEs capable of growth and successful internationalisation that have real potential for innovation via proper development of their products, processes, services or business model but who lack the right skills, knowledge and experience to manage the innovation activities. The aim of this scheme is to first of all support those SMEs in order to make them unlock their potential for better management of the processes linked to innovation.The project will be implemented as a testing phase from January 2015 until December 2016.


**Keywords:** innovation management, capacity building, EEN, innovation expert, SME Instrument, Key Account, Management, Horizon 2020, enhancing innovation performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improvement of working conditions for heavy nutsetting systems' in the context of a Fifth Framework call.

assistant: **Objectives**

Nut setting systems are often used in automotive and machinery industry. Systems for tighten M 16 - M 30 screws are heavy, difficult to operate and have a high risk of injuries. The main RTD goals can be described as followed:1. Installation of an ergonomic workplace with the benefits of reduced illness of the operator and accident rate.2. A process controlled screwing system with secure screw connections. The result of a controlled screwing is the application of smaller screws with a lower tightening torque, reduced wall thickness of the screw connections and consequently a lighter design of machinery parts.3. Low weight design for the nut setting system using lighter or higher strength materials for the torque transmission and the body of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel technologies for enhanced energy and exergy efficiencies in primary aluminium production industry' to be submitted under Seventh Framework.

assistant: **Abstract**

Primary aluminium production industry is the world’s larger industrial consumer of energy and ranked among the most CO2 intensive industries. It also generates enormous quantities of wastes that further decrease the exergy efficiency of its production process. However, this industry is one of the most vital sectors from economic and social point of view, not only for EU but also for the entire world. In order to remain viable and competitive, primary aluminium industry has to operate in a smarter way, be more energy efficient and meet the environmental requirements of our times. This can be achieved only through radical new technologies and novel business strategies, which will enable the industry to maintain its competitiveness and fasten its viability in the world’s markets, and explore new business opportunities. The main goal of this project is to provide primary aluminium industry with “green” innovative technological and economical solutions, focusing on the: (i) significant improvement of energy and exergy efficiencies of the production process; (ii) substantial reduction of GHG emissions; and (iii) complete elimination of the solid wastes. In order to achieve this goal within the project, novel technologies for the reduction of alumina to aluminium and the complete utilization of the red mud will be demonstrated and validated in pilot-scale. These technologies are energy-efficient and environmental-friendly, ensuring the competitiveness of the industry. A site optimization study of the new industry, integrating the novel technologies, is expected to achieve further reduction of energy and CO2 emissions and improve the energy and exergy efficiency of the whole process. It is aimed that the novel technologies will play a key-role on the sustainability, competitive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Universality in TopologicalDynamics'.

assistant: **Concept**

The aim of the project is to investigate the phenomenon of universality in Topological Dynamics. Universality is a classical and fundamental subject in Dimension Theory. The introduction of universality to the context of dynamics is more recent but has already proven itself to be fruitful. The far reaching Lindenstrauss -Tsukamoto Conjecture is the claim that mean dimension and periodic dimension are the only obstructions for embedding in the dynamical context. Mean dimension is an invariant introduced by Gromov a decade ago and has already found applications in diverse fields such as Symbolic Dynamics, Cellular Automata,  Holomorphic Functions , Mathematical Physics  as well as in Topological Dynamics, notably in Boyle-Downarowicz Symbolic Extension Entropy Theorem and its Z^k -generalization by the Researcher. The project also tackles related conjectures involving the small boundary property, the topological Rokhlin property (a topological analogue of the celebrated  Rokhlin Lemma from measured dynamics) and the dynamical version of the classical Sum Theorem from Dimension Theory.The Researcher, a PhD from the Hebrew University who is currently a postdoc at the University of Cambridge seeks to integrate at the Institute of Mathematics of the Polish Academy of Sciences (IMPAN) which has a long and distinguished history in Topology and its applications. The Researcher worked at IMPAN for 9 months, during which the fit between the Researcher and the Institute was evident. It is certain that this Career Integration Grant will enable the first step of a life long academic career at the Host Institute. Moreover the project by its quality, originality and novelty will contribute to the EU excellence, as well as to the Host Institute through transfer of knowledge through cour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Role of PGC 1ß co-activator in the brain: energy homeostasis, obesity, ageing and neuronal death'.

assistant: **Innovation**

Food intake and energy expenditure are the main components of energy balance and both are regulated by the central nervous system (CNS). Failure of these homeostatic mechanisms results in deregulation of lipid and glucose metabolism leading to insulin resistance and obesity.Defects in energy homeostasis may impact neuronal survival and accelerate the neurodegenerative process associated with ageing. The CNS receives peripheral nutritional signals that acting on specific hypothalamic nuclei and controls the energy balance. PGC1a is a coactivator of several transcription factors, involved in thermogenesis, mitochondrial biogenesis and energy expenditure; and its genetic ablation generates lesions in the striatal region of the brain.My project will focus on P GC1ß, a new coactivator homologous to PGC1a, which is highly expressed in heart, skeletal muscle and relevant for this proposal also in brain. Our aim is to understand the role of PGC1ß in the brain lipid and glucose homeostasis and their pathological states such as insulin resistance, obesity, neuronal death and ageing.I will investigate these using two complementary strategies:- I will characterize the specific pattern of PGC1ß gene expression in the mouse brain using a PGC1ß promoter driven GFP transgenic mouse model and- I will characterize the effects of PGC1ß in brain using the PGC1ßKO and if necessary neuron/nuclei specific PGC1ßKO mouse models using a Cre/lox approach.To investigate these aims we will use genetically modified mouse models combined with- transcriptomic profiling,- cerebral imaging analysis, complemented with- intracerebral stereotaxic injections of viruses over-expressing PGC1a and ß and d) electrophysiologic techniques.The relevance of the outcome of the study will be the extensive characteriz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Solving the greatest problem of surveillance: To see without being seen' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

With a market value of USD 18.14 Billion in 2017 and projected to reach USD 52.30 Billion by 2025, Unmanned air vehicles (UAVs), colloquially called drones, are defined as “an unmanned aircraft or ship that can navigate autonomously, without human control or beyond the line of sight”. However, their widespread implementation is restrained by the noise and obtrusive appearance limitations of commercialized technologies in either flight range or usability. For this we, Flygildi, developed SILENT FLYER: “An entirely new drone design solving the greatest problem of surveillance -to see without being seen”. SILENT FLYER is a Small UAV (or small unmanned air system, SUAS), which is an autonomous flapping wing bird-like robot. It looks like a bird and flies like a bird: It uses flapping flight for lift and propulsion instead of propellers. It will revolutionize the drone’s market by introducing the first UAV that combines silent flight (<70dB of noise emission) and bird-like appearance while incorporating accurate vertical take-off and landing (VTOL) capabilities to operate in turbulent weather conditions. SILENT FLYER can fly for >40 mins under favorable conditions (due to the ability to utilize wind currents during soaring, like a bird) and >300m maximum altitude of operation and do accurate landings relative to the ground. This makes it the perfect solution for 1) Civil use and surveillance, 2) wildlife photography & research.Moreover, SILENT FLYER will also represent a great boost for our company, not only regarding revenues, but also for our staff, since we plan to increase our staff a 120% from 8 to 18 people, in order to reach our production needs.