RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Physiological and genetic drivers of male paternity success'.

assistant: **Objectives**

Understanding the forces that create variation in individual fitness is fundamental to predicting population and evolutionary dynamics. Yet major questions regarding the causes and consequences of variation in fitness remain unanswered. Variation in male ‘paternity success’ (i.e. success in siring offspring) is a major fitness component that underpins multiple key evolutionary processes. Understanding the causes and consequences of this variation is consequently an ongoing challenge in evolutionary ecology. Progress requires integration of multiple disciplines, including physiology and quantitative genetics, to quantify determinants of paternity success in natural populations.In PatSuccess, I will provide new insights into key forces that shape variation in male paternity success and reproductive fitness. My objectives are to 1) quantify effects of inbreeding on key sperm performance traits and oxidative damage, thereby linking inbreeding with physiology and fitness in a wild population; 2) quantify relationships between key sperm performance traits and oxidative damage and male paternity success, thereby identifying physiological predictors of reproductive fitness; and 3) estimate heritability of male paternity success and additive genetic covariance with female multiple mating, thereby testing key hypotheses explaining the evolution of male and female reproductive strategies.I will achieve these objectives by developing and applying new measures of sperm performance and oxidative damage and state-of-the-art quantitative genetic analyses within an outstanding long-term field study on song sparrows (Melospiza melodia) where >20 years of paternity and pedigree data are already available.PatSuccess will thereby provide novel empirical understanding of the forces that shap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Universal, open-source and cybersecure Digital Twin to provide investors in onshore wind farms valuable insights about current operations and future investments.' to be submitted under Horizon Europe.

assistant: **Abstract**

TWINVEST intends to create the foundations of a universal, open-source and cybersecure Digital Twin to provide investors in onshore wind farms valuable insights about current operations and future investments. Guide investment decisions in wind energy is a complex as it involves various factors to monitor or assess such as energy production, maintenance, investment framework and characteristics of the wind farm. In order to tackle those different factors, a team of 14 partners have united to create a Digital Twin that seamlessly integrates and considers all these factors. This Digital Twin will have different platforms: i) Framework investment conditions platform focuses on energy storage, energy demand and pricing dynamics, regulatory mechanisms, and the essential grid requisites for ancillary services; ii) Component to Farm platform, focused on different components used for the turbines nominal energy production CAPEX estimation of the investment; iii)Environment and Earth platform’s objective is to assess the impact of weather and wind dynamics, culminating in the provision of real-time energy production projections; and iv) Maintenance and risks platform aiming to optimize OPEX by leveraging predictive methodologies to anticipate potential system failures.The project duration will be 42 months and it will be structured in 3 stages: Stage 1: Platform and model development where the research partners will develop, train and explore different AI models that allows the investor to forecast and monitor essential factors in a wind farm Stage 2 (M6-M42): Digital Twin Integration, where the different mentioned platforms will be integrated ensuring the interoperability among all models; and Stage 3 (M25-M42): Individual Platforms and Digital Twin validation, where the TWINVE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modulation of the recruitment of vessels and immune cells by malignant tumors: Targeting of tumor vessels and triggering of anti-tumor defense mechanisms' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

All malignant tumors acquire the efficient recruitment of blood vessels which are necessary for tumor growth. They also stimulate lymphangiogenesis supporting the dissemination of tumor cells not only via the blood vasculature, but in addition via the lymphatic system leading to metastasis. Vessel growth is promoted by sprouting angiogenesis and the homing of bone marrow progenitor cells into the tumors and tumor vessels. The extensive vascularization facilitates invasion of cells of the innate and adaptive immune system, which stay functionally suppressed by the tumor environment and contribute to tumor growth by factor secretion. We propose in this application i) to further investigate selected pathways and key regulators by which tumors promote vascularization and inhibit immune cell function, ii) to develop methods to inhibit tumor growth and metastasis iii) to achieve tumor clearance by promoting activation and homing of functional immune cells to the tumors. The project will comprise the collaboration of laboratories with complementary expertise in blood and lymph vessel angiogenesis, metastasis, progenitor cell incorporation into tumors, anti-tumor defense mechanisms and viral transduction techniques. The final goal will be the preclinical evaluation of anti-tumor therapies in murine models of three of the most prevalent human forms of cancer. The strategies to target the tumor will be based on gene, cell and immune therapy methods. It will include the use of i) adenoviruses for the expression of angiogenesis inhibitors following targeted delivery of the viruses to the tumor vasculature, ii) the genetic modification of murine embryonic and human bone marrow progenitor cells and their directed homing into the tumor and iii) the use of genetically engineered immune
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flexible electronics integrating 3D nanostructured electrodes for cellular-resolution in-depth electrophysiology recordings from developing spheroids and organoids' (SPHELECTRO).

assistant: **Innovation**

Three-dimensional neural models such as spheroids and organoids hold the potential to recapitulate several aspects of the human brain at the level of gene expression, cell differentiation, network and formation, thus representing one of the most promising technology to study brain development as well as neurodegenerative disorders. Suitable for large-scale production and genetic engineering, 3D brain models represent a highly encouraging model for next-generation drug screening assays. However, the electrical functionality assessment of such 3D models and its relevance to the human brain is still at its infancy, with current techniques limited to acute electrophysiology recordings through invasive or superficial tools. In this project, through the combination of expertise from the researcher in flexible neuroelectronics and surface functionalization, and from the host in nanotechnology-based electrophysiology and iPSC organoids, the overall scientific objective of the SPHELECTRO project is to develop a Seamless Array of Flexible Electronics (SAFE) with 3D nanostructured electrodes, integrated into 3D matrix-free brain models (spheroids and organoids) during early stages of development for prolonged, routine electrophysiology recordings with cellular resolution. This original proof-of-concept would provide an exceptional tool for the neuroscience community to advance our understanding of brain development and neurological disorders, with high industrialization potential in the pharmacology field. The timeliness and high interdisciplinarity of this project, at the intersection of fast-growing research topics such as flexible electronics, nanotechnology and organoids, will greatly build up skill transfer between the host laboratory and the researcher, as well as to enable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Organoboron-Based Luminescent Nanomaterials via Crystallization-Driven Self-Assembly'.

assistant: **Innovation**

The scientific objective of this proposal is to incorporate luminescent organoboron functionality into PFS-based block copolymers. In doing so, functional nanostructures will be created by crystallization-driven self-assembly, and their potential applications in nanoscale display technology, bioimaging, and biodiagnostics will be investigated. The exceptionally talented applicant, Dr. Hudson, has extensive experience in organoboron chemistry, luminescent materials chemistry and displays from his Ph.D. in Canada. The Manners group in the UK has well-known internationally-leading expertise in polymer and materials science, block copolymers, and crystallization-driven self-assembly. Thus, the experiences of Dr. Hudson and the Manners group are fully complementary and both are essential for the proposed research to succeed. At the end of the proposed 2 year fellowship period Dr. Hudson aims to return to Canada to a faculty position at a top research-intensive University.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The scale-up of the BioMilk platform: The revolutionary approach to manufacturing of biopharmaceuticals' (BioMilk-mAb) under Horizon Europe.

assistant: **Objectives**

Bio-Sourcing has developed a BioMilk platform, a new paradigm-shifting technology to produce biosimilar molecules in the milk of genetically engineered goats. This breakthrough development producing genetically modified goats using CRISPR-Cas9 produces 100% pure progeny of goats with genes of interest of biosimilar. Our bioproduction method is up to 5x more cost-efficient reducing costs from €100-200 of to €25 per gram of API and has 10x less CAPEX reducing investment costs from €200-300 million to 35 million and 1000x lower Co2 footprint reducing it from 25T to 5 per Kg of API, compared to conventional methods, allowing its scalability and industrialization with significantly less carbon footprint. The BioMilk platform has the potential to be market creating and disrupt the biotherapeutics manufacturing and biosimilar markets with an enormous market opportunity of €100B. The main goal of the project is to successfully complete the non-clinical analytical studies for three biosimilars with the highest market potential and perform the phase-I clinical validation of the first biosimilar. This will help Bio-Sourcing to close a licensing deal for the sales of the biosimilars to a pharma or biogeneric-producing company by 2027. Bio-Sourcing will remain the exclusive producer and act as a supplier of API to its customers who will sell fully formulated biosimilars. Bio-Sourcing is expected to receive upfront payments and milestones (€40M in total per biosimilar) and generate longer-term revenue through sales of API and royalty payment on net sales (5%). Bio-Sourcing seeks EICA blended finance (€2.5M grant and €10M equity), which will enable Bio-Sourcing to reach its value inflection point of successfully completing the important Phase I study for the first biosimilar from the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'BIM and GIS Integration for Archaeology: a new method for documenting field archaeology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The BIGAr project aims to innovate archaeological research methodology developing a digital application to integrate representation software (Building Informative Model -BIM- and Geographical Information System -GIS-) to document the 4D nature of archaeological evidence as well as their traditional information (i.e. text or photography). This approach can be quicker and more complete than others currently used; it allows a higher degree of collaboration via Web as well as it provides a new frontier for spatial analysis and management of Cultural Landscape. So far, in archaeology, the use of BIM is only applied to architectural analysis and never integrated with GIS. Thus, I will use innovative geospatial environment, developing a new digital workflow of integration GIS and BIM, for managing archaeological data, collected in field works as excavations and surveys. To achieve this target I will develop a dedicated application based on an original programming script, using open source software. Such a research will be possible merging competences and laboratories of the 3 involved Organizations: the University of Michigan (outgoing phase, supervisor Prof. Nicola Terrenato), the University of Minho (secondment, supervisor Prof. Miguel Azenha), and the University of Bologna (return phase, supervisor Prof. Andrea Augenti). The field data will come from two projects active in the area around two ancient capitals, Rome (Gabii Project, University of Michigan) and Ravenna (Ravenna Landscape Archaeological Project, University of Bologna). As part of the MSCA-IF-2020-GF action at the Universities of Michigan and Minho, two world leading institutions in this field, I will receive the necessary high-quality training, which will allow the continuation of a successful career in the fie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Innovating South Muntenia' (INNSOM), addressing dissemination and exploitation.

assistant: **Impact**

The development of the Regional Innovation Strategy in South Muntenia Region will serve as the main focus of all project activities. The strategy will be prepared based on a strong partnership that will bring together representatives of private enterpris e, business support organizations, R&D and education, local authorities and NGOs. The key actors representing specific sectors will work together towards developing their capacity to participate effectively in the planning and delivery process. Thus, the regional network will be interconnected with the foreign partner regions and furthermore will consolidate a European platform for exchange of experience and dissemination of good practices on innovation-related themes among key regional actors. Th e project will include an assessment of SME support services and innovation supply, identification of regional business needs and an audit of R&D activities and infrastructure. This research will form the basis of the RIS and will also feed into oth er local, regional and national plans, providing a framework for a better absorption of EU funds. South Muntenia is an attractive location for inward investment and the counties in the North of the region have already been successful in attracting FDI. A main focus of the strategy will be the creation, across the whole region, of an environment which encourages high value added foreign and domestic investment, increases the local multiplier effects of such investment and promotes this to investors. Th e project and the strategy will ensure the development of indigenous business. This will be initiated through an awareness raising campaign on the importance of innovation and through working with SMEs and research and education institutions to increase investment in R & D and the imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Securitization versus Depoliticization in the European Union Asylum and Migration Policy: The Role of the New Agencies (FRONTEX, EASO & Large-Scale IT Systems Agency)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project examines the evolution of the European Union (EU) asylum and migration policy. It aims to elucidate an important apparent contradiction at the heart of this policy: the simultaneous co-existence of two seemingly opposite trends – ‘securitization’ on the one hand and ‘depoliticization’ on the other hand. The research project aims to account for this apparent contradiction by developing an original multidisciplinary theoretical framework, which combines insights from security studies, public policy and European studies. In addition to this original theoretical contribution, the proposed project will generate new empirical knowledge through the application of this new theoretical framework to three case studies. Those will concern the three European agencies dealing with asylum and migration, which have already been or are in the process of being established (FRONTEX, EASO and the Large-Scale IT Systems Agency). Data will be gathered and analysed according to the principle of methodological triangulation between the analysis of secondary sources, documentary analysis and semi-structured elite interviews. This research project will contribute to strengthening European excellence in social sciences, in particular in security studies, European studies and the study of governance by agencies. In addition, the proposed project will generate policy-relevant findings, which will be of interest to policy-makers dealing with asylum and migration issues and/or agency creation in any policy field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Learning to read the code of large neural populations' (NEURO-POPCODE), addressing dissemination and exploitation.

assistant: **Impact**

Information is represented and transmitted in the brain by the joint activity of large groups of neurons. Understanding how information is “written” in these population patterns, and how it is read and processed, is a fundamental question in neuroscience. Yet, because of the huge number of potential activity patterns and complexity of natural stimuli, most of our understanding of the code relies on single neuron studies. We will extend and apply mathematical tools from information theory, machine learning, and physics, to overcome this ‘curse of dimensionality’ and build neural dictionaries relating activity and stimuli at an unparalleled resolution of hundreds of neurons. To identify the fundamental design principles of neural population codes we will study the spatial and spatio-temporal activity of hundreds of neurons from the retina, tectum, and cortical networks responding to naturalistic and artificial stimuli. Our primary goals are: (a) to characterize the encoding ‘codebooks’ of large populations of neurons, and the effect of network noise on encoding, and thus construct a thesaurus for neural populations, (b) use this thesaurus to develop new family of decoders of population activity which would be biologically plausible and accurate for natural stimuli, (c) characterize adaptation at the level of the code of networks of neurons, and the effect of learning on population neural codes, (d) explore “learnability” as a key feature of the neural code, and construct biologically plausible models of how the brain can learn to read population codes and compute, and (e) merge these ideas into a new mathematical framework that will connect the architecture of neural interaction networks and the properties of their neural codes. Our work will establish a new mathematical