RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ecological Planning and Economic Rationalities: Political and Epistemological Theories in the Age of Polycrisis'.

assistant: **Concept**

EcoPlanAge revisits planning as one of the crucial political concepts of the 20th century and offers a new conceptual framework for democratic ecological planning in the 21st century. With climate change, the pandemic and the war in Ukraine, expressions like ‘war economy’, ‘plan’ and ‘new deal’ have ceased to be relics of the past. Degrowth (DG), Green New Deal (GND) and Green Growth (GG) rationalities are either praising or criticizing planning as an effective tool to tackle our polycrisis. Yet, some celebrate its democratic nature, others perceive it as authoritarian. EcoPlanAge identifies an urgent need for conceptual clarification: what precisely does planning mean in the contemporary era? On what grounds is it praised or criticized? By crossing political theory, conceptual history and political ecology it shows how DG, GND, GG rationalities are still influenced by the two strains that have characterized the 1920s socialist calculation debate on planning possibilities: the formal rationality of neoliberalism and the substantive rationality of socialism. EcoPlanAge selects four authors who affect eco-planning debates: Ludwig von Mises and Friedrich August von Hayek (neoliberal strain); Otto Neurath and Karl Polanyi (socialist one). It reconstructs their epistemological and political theories and analyzes the conception of nature, time and gender that underpin their planning frameworks by highlighting the interrelation between their political theories and the concrete historical planning experiments of their time (war economies, Red Vienna, New Deal, Fascism, Nazism, Soviet planning). Finally, it discusses the utility of these planning theories in thinking about a new conceptual framework for democratic eco-planning in our age of polycrisis. The project will be carrie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'New directions for studying circadian biology in the wild' (WILDCLOCKS) targeting Seventh Framework.

assistant: **Abstract**

Powered by molecular tools, circadian research rapidly reveals a key role of biological rhythms in physiology and health, but clock function is poorly understood in its organismic and environmental context. Because clocks integrate multiple rhythmic processes, they need to be finely adjusted to environmental conditions. To address how genes and environment shape timekeeping, I combine frontline molecular tools and field-based approaches in the study of an avian model species in ecology and evolution, the Great Tit (Parus major). This research thrives on the complementarity of expertise and facilities of my host institution and the strengths that I bring. The project will lay the foundations for a long-term study system of biological time-keeping across levels of biological organization that will advance our understanding of the ways clocks aid fitness and health. Specifically, I will use cross-fostering designs and telemetry in the wild to test for early-environment effects on daily timing (’chronotype’), I will examine birds in captivity to quantify endogenous clock features, and use high-throughput molecular profiling technologies to advance the genotype-phenotype link in chronobiology. The research is based on my earlier findings of highly heritable, but nonetheless dynamic circadian clocks, which I can now greatly expand through the combined assets of the field station SCENE and the cutting-edge tools and analytical expertise for integrated analysis of multi-level ‘omic data at the University of Glasgow. The hosting Institute of Biodiversity, Animal Health and Comparative Medicine, is an internationally leading centre of multidisciplinary research with the mission of using ecological expertise to address urgent problems of today. With its unique focus and combinatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EGNOS Adoption in the Aviation Sector' (GIANT-2), addressing dissemination and exploitation.

assistant: **Impact**

The GIANT-2 Project intends to accelerate the adoption of EGNOS in the aviation sector, specifically in the Regional, Corporate and General Aviation, as well as the Helicopter SAR areas, focusing on the Topic’s primary objective.The previous GIANT project has successfully promoted and trialled the introduction of EGNOS applications in the area of Regional Aviation, Helicopter HEMS (Medical) operations and  North Sea Oil Rigs operations. In fact, within this project, the EGNOS enabled LPV approaches were flown, for the first time in Europe, by aircraft of a commercial airline, Air Nostrum (not experimental, nor test aircraft).The GIANT-2 project will constitute an step forward by promoting and accelerating the EGNOS aviation applications in the other key niche markets interested in the EGNOS use, i.e. the areas of Corporate and General Aviation, School and Training Aviation and Helicopter SAR (Search and Rescue) operations. These activities will constitute specific Work Packages in the GIANT-2 project, namely WP 3, 4 and 5, respectively.Special effort will be devoted to the topic’s secondary objective in order to identify testing and operational practices that will lead to a successful EGNOS adoption, knowledge building and dissemination to a Europe-wide network of aviation community members with strong interest in GNSS technology, focusing on showing economic and operational benefits to end users. Specific Work Packages will be devoted to this objective, namely WP 1, 2, 6, 7 and 8.End users are the main community and decision makers in order to introduce and adopt the usage of the EGNOS system and service in all markets. In aviation, airlines, helicopter operators, aircraft owners and pilots constitute the end users community, and they are key partners of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of factors that promote the survival of multiple myeloma' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Plasma cells are responsible for secretion of immunoglobulins (Ig) into the bloodstream, which constitute the humoral immune response. XBP-1 is a transcription factor necessary for the terminal differentiation of B cells into plasma cells. XBP-1 is required for the synthesis and the maintenance of high levels of Ig, and plays a critical role in setting the conditions for their assembly and secretion. Multiple myeloma (MM) is the cancer of plasma cells, and in most cases this cancer retains the capacity to secrete high levels of Ig. MM is impervious to conventional chemotherapies, and constitutes 2% of total deaths from cancer. Recent evidence shows that XBP-1 promotes survival of MM cells. Since XBP-1 is destroyed with a half-life of minutes, we shall explore the mechanisms responsible for its degradation, as factors that may promote MM survival. We shall express recombinant XBP-1, and study its degradation by the proteasome in a cell free assay. In addition, we will use an RNA interference screening to identify genes required for the degradation of XBP-1. Bortezomib is a newly approved drug for MM, which blocks the proteasome.The reasons why MM shows remarkable sensitivity to bortezomib are unknown. Utilizing cells resistance to proteasome inhibition, we will strive to identify genes and biochemical pathways that confer resistance of MM to treatment with bortezomib. This study may identify novel targets and pathways for the therapy of MM, and provide better understanding of the regulation of XBP-1 levels.The overall aim is to combat cancer by broadening the knowledge base on molecular mechanisms underlying chemotherapy resistance. In accordance with the IRG objectives, my proposal will implement and transfer to Europe the technology developed at the Whitehead Institute
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Global Ecological Custodianship: Innovative International Environmental Law for the Anthropocene' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

International environmental law (IEL), with multilateral environmental agreements (MEAs) as its main component, has not been able to address the underlying causes that are responsible for the socio-ecological crisis of the Anthropocene and it seems unable to respond to this crisis. By providing the fellow with a sustained opportunity to interrogate IEL’s principal MEAs in the context of the Anthropocene, this project seeks to investigate a) the normative implications of the Anthropocene for law and IEL specifically; b) explain why and to what extent MEAs have contributed, and have been unable to respond to, the Anthropocene’s socio-ecological crisis; and c) to propose a global ecological custodial framework of care (GLEC-Law) to reform these MEAs. Lawyers have been unable to present a comprehensive solution to MEAs' deficiencies and failures, while Anthropocene scientists have been unable to meaningfully translate their insights into the juridical domain. Responding to this knowledge gap, this multi-disciplinary project brings together an experienced researcher and an internationally recognized research group with global expertise to problematize the failures, deficiencies and potential of MEAs in the Anthropocene and to propose reforms of these MEAs. The fellow brings expertise on environmental law, governance and constitutionalism to the host and secondment institutions, including access to global and global South networks, while contributing to establishing the host as a leading multi-disciplinary European center of excellence in law, governance and Anthropocene studies. The fellow will gain methodological and doctrinal training in IEL and Anthropocene related sciences. The project’s scientific importance, operationalised through its 3 work packages and associated sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Establish Pan-European Information Space to Enhance seCurity of Citziens' (EPISECC) targeting Seventh Framework.

assistant: **Abstract**

In a disaster situation three things contribute to a success: having the right resource available in the shortest time, with the highest relevance and at the right location.Access to necessary information, communication with other rescuers and stakeholders as well as the availability of resources are key factors in minimizing damage and loss of life.Large scale disasters and crisis situations increase the requirements on man and material exponentially.  Additional challenges, in particular in cross border events, include language barriers, knowhow and organizational barriers and technical barriers (communication and data exchange).To address this challenge it will be necessary to analyse three defining factors:1. Past responses to critical events and disasters in terms of time and cost2. The data and data management tool used by crisis managers and first responders3. The organisational structures of the crisis managers and first respondersThis analysis will enable the definition of a concept for a common information space.A requirement for a successful pan European information space is the definition of a common taxonomy.The common information space, which implies an EU wide standardization activity, will widen the EU wide market for organization developing solutions and tools for crisis management.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'eHealth platform to assess patient clinical progress due to prescribed medication' in the context of a Horizon 2020 call.

assistant: **Objectives**

The objective of prescribing medicines is to improve patient health. However, many times the expected results of medications are not achieved, which causes morbidity and mortality associated to medication use. These failures of prescription drug use have been published in numerous scientific studies and negatively affect patient health as well as cause economic damages (to patients in particular and society in general). But studies show that the majority of these failures are avoidable.Although expenses in healthcare to treat patients are high, the prevalence of morbi-mortality associated to drug prescription is high, mostly due to the fact that patients fail to follow doctor’s instructions on prescription and/or doctors duplicating therapeutics, which includes unforeseen drug interactions that can cause harm to patients.To this avail, FSaude, working closely with software developers, chemists, medical doctors and patients since 1960, has a team of 14 experts that have generated a 2,6M€ turnover in 2016, decided to develop an eHealth platform to assess patient clinical progress due to prescribed medication – DrBox. There is a market opportunity in improving a pharmacist’s capacity to provide Pharmaceutical Care, through a Therapeutics Management program, in order to reduce patient’s morbi-mortality related to drug use, improve patient’s quality of life and reduce overall costs to citizens and society. DrBox allows, for the first time in the history of modern health, the possibility for health program management entities (MD, pharmacies, nursing homes, etc.) to be able to receive in real time the epidemiological information needed to make decisions in the National Health Systems.At the present moment DrBox is being tested in three pharmacies and one nursing home, with a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '3D microscopy-guided assembly of novel hierarchical, multi-pore, multi-function catalysts for clean fuel production' under Seventh Framework.

assistant: **Concept**

Currently, there is a strong reliance on petroleum imports to satisfy Europe´s demand of liquid fuels and platform chemicals. For economic and environmental reasons, a shift in the raw materials base to greener natural gas and renewable non-edible biomass resources is a priority. Dealing with such non-conventional resources will require a significant decentralization, downscaling and intensification of the chemical processes. The rational development of new solid catalysts with porous structures tailored to control the traffic of molecules within their pores, and displaying multiple catalytic functions to effect several reactions in a cascade fashion will pave the way to these novel processes. The aim of ""3DMultiCAT"" is to synthesize a new generation of catalysts, with hierarchical and organized porosities at three length-scales (from Å to µm) and spatially compartmentalized functionalities. These catalysts will be applied in the wax-free synthesis of branched hydrocarbons from synthesis gas (CO+H2), which is obtained from natural gas or biomass. The catalysts will combine metal nanoparticles, to effect the Fischer-Tropsch synthesis of hydrocarbons, with acidic sites in nanosized zeolites, to in situ hydrocrack and isomerize the primary products, rendering liquid fuels in a single step. Essential is to overcome limitations of the state-of-the-art, such as intra-pore diffusion limitations for reactants (CO) in the working catalyst and the detrimental direct contact of the two types of catalytic sites. To this end, Tomographic (3D) Focus-Ion-Beam Scanning-Electron-Microscopy coupled to quantitative image analysis, and Electron Dispersive X-ray nano-spectroscopy, will be incorporated into the tool-box of catalyst design. Developed chiefly in the field of earth-sciences,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'UNCOVERING PATHOGENIC MICROPEPTIDES FROM THE HUMAN GENOME' (GENOMEPEP) targeting Horizon 2020.

assistant: **Abstract**

The human genome is over 3 billion nucleotides long, yet only 1,5% of it codes for proteins. In recent years, a striking number of regions of the genome have been discovered to be capable of being transcribed and translated into short polypeptides. These micropeptides comprise of less than 100 amino acids and to date, more than 160 000 different micropeptides have been catalogued within human tissues. These protein products are hypothesized to participate in numerous molecular, cellular and physiological processes, yet the function of but a few micropeptides has been identified. Subsequently, due to its largely unknown functionality, the micropeptidome is commonly overlooked during genomic studies.Due to increasing life expectancy and detrimental lifestyle habits, the European population can be considered to be a high-risk population for cardiovascular diseases, which cause millions of deaths per annum, while taking a tremendous financial toll on the regional economy. GENOMEPEP aims to pinpoint novel micropeptides participating in the pathogenesis of cardiovascular diseases by investigating the genetic variation within the micropeptidome-encoding genome in correlation to existing common cardiovascular phenotypes in population. This will be achieved by establishing a computational analysis pipeline based on biometric, genotype and health records data available within the Estonian and Finnish biobanks. The identification of novel pathogenic genes and the development of guidelines to investigate the micropeptidome would assist in the advancement of research, diagnostic medicine and pharmacology both in public and private sectors.The results of GENOMEPEP will address the CVD research aspect highlighted in “Societal Challenge 1” work program of Horizon 2020, as well as impro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'REcasting psychological interventions for Customizing, Optimizing, Validating, and Enhancing Recovery of chronic pain patients' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Chronic non-cancer pain (CP) negatively impacts all areas of functioning, severely limiting quality of life and increasing the risk of mental disorders. Psychological interventions are a key part of treatment, with meta-analyses showing small to moderate effects on pain intensity and associated outcomes. Psychological interventions are themselves complex, with multiple, distinct components. There is presently no taxonomy of these components and no information about which components are the active ingredients supporting the treatment effect, which are redundant or even harmful and whether some patients respond better to some components rather than others. The RECOVER project is premised on two principles: (1) to optimize treatments, we need to know their building blocks; (2) to improve treatment response, we need to examine patient-level predictors of responses. The aims of RECOVER are (a) decomposing complex psychological interventions for CP; (b) re-evaluating efficacy by examining the specific contributions of components and combinations; c) examining patient characteristics (e.g.,age, gender, pain history) predictive of better response to components or combinations and d) creating an open app based on the project findings, allowing users to personalize treatment by selecting the most effective components. The methodology will involve retrieving and reutilizing individual participant data from randomized controlled trials of psychological interventions for CP and using advanced meta-analytic methodology such as component network meta-analysis. Training activities will span the entire project duration, and the outcomes will be presented at international conferences and submitted to top-tier, peer-reviewed journals. RECOVER has the potential to make important strides to