RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Forced response of turbomachinery blades' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content This proposal deals with the vibration analysis of turbomachinery rotor blades which are subjected to time-varying aerodynamic forces produced by the gas flow past the stator blades, the industrial term for the phenomenon beingforced response. State-of-the-art analysis and design tools for estimating such aeroelastic behaviour are deficient in terms of predicting blade response levels quantitatively and hence blade fatigue life cannot be assessed to a required degree of accuracy. It is therefore proposed to develop a numerical predictive model with the following features: (i) accurate modelling of the unsteady flow including wake behaviour and gust response, (ii) structural model including non-linear friction damping, (iii) flexible rotor blades and their effect on the flow, and (iv) adequate representation of blade cooling. Training content (objective, benefit and expected impact) The objective of the project is to acquire a deeper knowledge and a wider competence in the field of fluid-structure interaction in a turbomachinery environment. This is multidisciplinary topic in which the applicant has a good basic knowledge and for this reason the benefit and the expected impact can only be positive. Links with industry / industrial relevance (22) The work will take place at the Centre of Vibration at Imperial College which is a Centre of Excellence in these studies. The Centre has very close links with Rolls-Royce plc which will contribute to the project by making available in-house expertise as well as measured data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A cost and time effective blood test to detect multiple bloodborne diseases' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the European Union alone, 15 million blood donations are collected annually, but supply of sufficient and safe donor blood remains a continuous struggle. Blood can save lives; however, it also carries the potential to transmit life-threatening infections. Potential donors are screened using a questionnaire aimed to identify risk carriers. As risk carriers do not equal disease carriers, thousands of potential donors are excluded to prevent one single case of a transfusion-transmitted disease. Subsequently, blood donations are screened for infectious diseases in the laboratory with one test for each disease. WAMA Diagnostics is a Swiss-founded company with the ambition to disrupt the in vitro diagnostics market with affordable and reliable tests to diagnose infectious diseases. WAMA has the expertise and technology to convert multiple tests into one single test, reducing time and money. WAMA is developing the Safe-Blood test to simultaneously screen for HIV, Hepatitis B, Hepatitis C,  Syphilis, HTLV and Chagas in a single test. Our preliminary cost-benefit analysis demonstrates the potential to reduce the screening costs from €70 - €250 per donor to €15 per donor. 1,400 European blood donation banks are responsible for the collection of the 15 million blood donations per year. The global blood screening market is expected to grow from €1.3 billion in 2015 with a Compound Annual Growth Rate of 10.2% to €3.1 billion in 2024. The competition is offering solely monoplex  tests: one test for one disease. There are currently no players on the blood screening market that use multiplex tests to screen for multiple diseases simultaneously, and the Safe-Blood test will hold a unique position in the market. WAMA will use the SMEi phase 1 funding to assess the feasibility and comm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Making Old Objects Valuable Again. The Cultural, Economic Challenges and Sustainability Opportunities of Antiques in the 21st Century'.

assistant: **Concept**

What do old porcelain, wooden furniture, and silverware have in common? All of these antiques fall into the category of informal heritage. Regardless of their cultural significance, many of these objects remain on the margins, both in cultural institutions and scholarly research. As a result, the question of how antiques are safeguarded, valued, traded, perceived, and consumed remains largely underexplored. By studying the contemporary economy of antiques, MOOVAs prime objective is to highlight the potential of these objects regarding the safeguarding and promotion of informal heritage, sustainable consumption, new business models for ageing sectors, and local city development. More specifically, MOOVA aims to: 1) demonstrate the patrimonial role of antique dealers as vital safe-guarders of informal heritage; 2-3) explore the market structures at play within the antiques trade, its economic impact, and the supply and demand for antiques in a digital economic context; 4) understand how antiques are perceived by younger generations (Gen Z); and 5) develop a theoretical and practical model for renewing the meaning and value of these complex objects. Through selected case studies (European decorative arts) and a multi-transversal approach (cross-markets, objects, countries), the project will combine theories, data, and methods from art history, cultural economics, cognitive science, and arts marketing to investigate this topic holistically. The first stage will consist in data collection and processing, using new databases of evidence drawn from primary and secondary sources (incl. interviews and sales results), while the second will be dedicated to the development of the reevaluation model. MOOVA's overreaching goal is to progress towards more advanced scholarship in art m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Controlling Gene Expression with Synthetic Cell-Penetrating Transcription Factors' under Horizon Europe.

assistant: **Concept**

The overarching goal of SynTra is the engineering of synthetic transcription factors (STFs) that can enter cells and activate or deactivate specific genes. Traditional drugs target only a small fraction of the human proteome, while compounds that can be programmed to target specific genes could address many relevant disease mechanisms, right at their basis. In aim 1, I will engineer STFs that can (1) bind to any given DNA base pair triplet and (2) enter cells. To achieve these goals, I will develop design rules for preparing minimized ?-helical scaffolds derived from zinc finger protein domains. Via peptide stapling, I will stabilize the structure of these STFs and boost their cell internalization. I will use a high throughput combinatorial screening methodology developed by me to optimize the STFs? properties. In aim 2, I will prepare multimeric STFs (consisting of multiple monomeric STFs from aim 1) that can target unique genes within the entire human genome with high specificity. I will obtain them with a combination of solid-phase and bioconjugation strategies. With a hexameric STF (recognizing 18 DNA base pairs), I will target a specific gene promoter and trigger ?-globin production as a promising strategy for sickle cell disease treatment. In aim 3, I will use STFs to disrupt cancer-related liquid-liquid phase-separated transcriptional condensates. Transcriptional condensates rely on a network between transcription factors, DNA, and coactivators, and they play a crucial role in gene transcription. With STFs, I will displace the oncogenic transcription factor MYC from its DNA binding site. I expect this interference to lead to a condensate disruption and to downregulation of oncogenic MYC-dependent transcription. SynTra will deliver powerful and practical synthetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fluorescence and Reactive oxygen Intermediates by Neutron  Generated electronic Excitation as a foundation for radically new cancer therapies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Deep lying tumours like aggressive brain cancer remain very difficult to treat and existing therapies offer only marginal increase in survival rates. In the case of photomedical therapies they are very effective, but mainly limited by their insufficient depth of light penetration into tissue. Current neutron-based therapies have sufficient penetration depth but suffer from lack of cancer specificity. In FRINGE we propose a genuinely new hybrid-technology. At its heart are chemical agents (photosensitisers - PS) which preferentially accumulate in the tumours especially in brain cancers where the blood brain barrier is compromised. The PSs designed for FRINGE will contain metal centres like Gadolinium (Gd), to enable interaction with incoming neutrons and facilitate the transfer of neutron energy into electron excitation of the PS, confirmed by concomitant fluorescence emission. Interaction with ambient oxygen will generate reactive oxygen species which will kill the tumour cells. The main scientific breakthrough of this project will be to establish experimental proof-of-principle of this novel neutron-activated therapy. FRINGE will combine the advantages of photomedical therapies (no mutagenic radiation) with the advantages of neutron-based therapies (large penetration depth). The externally-applied neutron beam  can be  energy-tuned to become therapeutic exactly at the depth of the tumour. Exploiting Gd as a contrast agent, FRINGE can also become a theranostic modality by use of magnetic resonance imaging. FRINGE has  the potential of causing  immunogenic cell death to cancers which could eliminate occult metastasis and act as a ‘cancer vaccine’. The highly interdisciplinary project team comprises world renowned experts from a unique combination of disciplines: Nuclear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Interactive and Explainable Human-Centered AutoML', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Trust and interactivity are key factors in the future development and use of automated machine learning (AutoML), supporting developers and researchers in determining powerful task-specific machine learning pipelines, including pre-processing, predictive algorithm, their hyperparameters and--if applicable--the architecture design of deep neural networks. Although AutoML is ready for its prime time after it achieved impressive results in several machine learning (ML) applications and its efficiency improved by several orders of magnitudes in recent years, democratization of machine learning via AutoML is still not achieved. In contrast to previously purely automation-centered approaches, ixAutoML is designed with human users at its heart in several stages. First of all, the foundation of trustful use of AutoML will be based on explanations of its results and processes. Therefore, we aim for:1. Explaining static effects of design decisions in ML pipelines optimized by state-of-the-art AutoML systems.2. Explaining dynamic AutoML policies for temporal aspects of dynamically adapted hyperparameters while ML models are trained.These explanations will be the base for allowing interactions, bringing the best of two worlds together: human intuition and generalization capabilities for complex systems, and efficiency of systematic optimization approaches for AutoML. Concretely, we aim for:3. Enabling interactions between humans and AutoML by taking human's latent knowledge into account and learning when to interact.4. Building first ixAutoML prototypes and showing its efficiency in the context of Industry 4.0.Perfectly aligned with the EU's AI strategy and recent efforts on interpretability in the ML community, we strongly believe that this timely human-centered ixAutoML will have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Physics on stage 3' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Physics on Stage 3' will be a Europe-wide programme of activities and events for physics teachers. Throughout the year 2003, a wide series of national activities will take place across 22 European countries, guided by National Steering Committees. These activities will identify the most motivating physics teaching methods and select the teachers with the most successful tools and innovative ideas for teaching physics. The best of the projects will be brought together during the European Week of Science and Technology 2003, when the project will culminate in a 5-day international festival. Approximately 400 teachers will gather at ESA-ESTEC in Noordwijk, the Netherlands to exchange ideas and best practices and discuss how to interest more young people in physics. There will also be associated activities covering other areas of science, such as biology. A report on the activities, including the recommendations of the teachers will be prepared and an online archive of the educational materials presented will be set up.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel porous graphite as cathodes for advanced aluminium-ion batteries' in the context of a Horizon 2020 call.

assistant: **Objectives**

The demand for electric vehicles (EVs) is expected to rise significantly to ~55% of all new car sales by 2040. This would necessitate ~0.8 million metric tons of Li-metal for standard lithium ion battery (LIB) production. However, a market dominant EV-industry would only have sufficient Li-supply for at most 17 years due to inevitable shortfalls on sustainable-supply of lithium. Aluminium based rechargeable batteries (AlBs) offer tantalising prospect of high energy density batteries using components that can facilitate safe-by-design production of cheaper, durable and sustainable batteries. This battery technology, while having enormous potential as a replacement for LIBs, has not yet demonstrated viability due to critical limitations, primarily the lack of an efficient cathode material that can cycle Al3+ or Al-ion complexes for high energy density and stability. By far, the most plausible cathodes for AlBs are based on graphitic materials. However, present graphitic cathodes are inefficient due to serious design flaws. This project will develop a rapid synthesis protocol to fabricate a very unique graphitic material with unprecedented brain-like morphology and also develop mechanisms to control the intrinsic nanopore architecture. The project will conduct a detailed structural analysis and characterisation of the novel graphitic framework as a cathode for AlBs. This novel graphite holds the key to a significant breakthrough and will advance the development of AlBs by: 1) addressing the issue of poor electrolyte penetration and improve the sluggish reversible ion intercalation to boost rate performance and cycling, 2) improve the weak electronic/electrical conductivity properties of present cathodes, 3) overcome the problematic abrupt cathode disintegrating during cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IN-orbit Validation of European Space Technologies' to be submitted under Horizon 2020.

assistant: **Abstract**

INVEST (IN-obit Verification of European Space Technologies), aims to provide a European-wide programme for enabling a more rapid maturization of European space technologies and components by offering an integrated, multi-platform IOD/IOV community.Europe has a unique technological position in the space market and continues to invest heavily in the development of new technologies. Although new concepts and technologies are continuously being worked on in European and national programmes, few find their way to flight programmes in a short time as they are often deemed to be too immature or unproven for early selection into a flight programme. As programme managers cannot afford to select unproven technologies, and technology developers need a flight programme to allow their innovations to be tested or validated in space before being able to be selected, innovation cycles in space are often delayed due to a lack of flight options for new developments. This proverbial technological valley of death is a serious risk for maintaining a state-of-the-art technological base for European flight projects. There is a clear gap in the available programmes and initiatives in Europe to ensure a sustained, structural IOD and IOV capability for new space technologies that ensures that higher level TRL innovations become available to the European flight programmes. In order to avoid getting trapped in a potential deadlock scenario where space innovation slowly grinds to a halt, the INVEST project will address this gap, research the key characteristics, requirements and constraints, and the project will work out a possible solution to improve the IOD/IOV capacity of Europe. During the project the outlines for a specific IOD/IOV programme will be developed that would allow innovative Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Integrated Structural and Probabilistic Approaches for Biological and Epidemiological Systems'.

assistant: **Innovation**

Systems in nature are extremely robust, despite huge uncertainties and variability. Studying their nonlinear dynamic behaviour is challenging, due to their complexity and the many parameters at play, but crucial to understand important phenomena, such as cellular dynamics, onset of diseases, epidemic spreading.Parameter-dependent simulations can predict the behaviour of natural systems case by case. Yet, the exact models and parameter values are poorly known, while qualitative behaviours are often preserved even with huge parameter variations, because they rely on the system interconnection structure. Parameter-free structural approaches can check whether a property is preserved for a whole family of uncertain systems exclusively due to its structure. However, when an expected property fails to hold structurally, novel approaches are needed to understand why, which system features prevent it, which key parameters must be finely tuned to enforce it.INSPIRE will develop a unifying framework to analyse and control families of uncertain dynamical systems in biology and epidemiology, which integrates for the first time structural, robust and probabilistic methods, tailored to the peculiarities of natural systems.The project will provide: i) methodologies to assess (practically) structural properties and unveil the mechanisms that enable/prevent a property, identifying the key parameters or motifs; ii) control paradigms that leverage such an insight to guarantee a desired global property through targeted local interventions; iii) scaling and aggregation approaches that exploit the properties of subsystems to mitigate computational complexity.The project outcomes, a mathematical theory as well as algorithms to analyse and control complex uncertain systems in nature, will stron