RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'MULTIfunctional optoelectronic devices based on hybrid heterostructures of 2D materials and photochromic SWITCHes' (MULTI2DSWITCH).

assistant: **Concept**

MULTI2DSWITCH will offer an extremely talented and promising young researcher, with a PhD in physics and an extraordinary track record, world-class training through research in the cross-disciplinary and supra-sectorial field of 2D materials (2DMs) based multifunctional electronics. The proposed research lies at the interface between physics, chemistry and electrical engineering, in the interdisciplinary realms of supramolecular sciences, materials- and nano-science. The overall mission is to train the fellow to become an independent scientist and to prepare him for a leading position in academia or industry. MULTI2DSWITCH’s research programme targets a fundamental breakthrough in the field 2DMs by using a combination of bottom-up and top-down methods to design ultraflat, flexible and photoswitchable heterostructures of 2D crystals and molecular self-assembled monolayers (SAMs). In order to do so, a highly-ordered SAM of photochromic molecules (azobenzenes, diarylethenes or spiropyrans) is prepared on the surface of a graphene layer, by means of low-cost solution processing techniques. The graphene/SAM bilayer is subsequently encapsulated with a 2D semiconductor from the family of transition metal dichalcogenides (TMDs) using the flake-transfer techniques commonly employed for van-der-Waals heterostructure assembly. The photo-tunable properties of the newly prepared hybrid heterostructures will be exploited to develop a series of proof-of-concept multifunctional devices, including optically-switchable diodes and field-effect transistors (FETs), and optically-programmable memory cells. Thanks to the high-degree of mechanical flexibility of both the 2D crystals and the molecular SAMs, these devices will be suitable for integration on flexible substrates. Ultimately, MULTI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancement the Quality Participation at FP6 Projects in the Polymer Nanomaterials Field' goes beyond current state-of-the-art under FP6.

assistant: **Innovation**

The analysis of FP6 programs results in 2003 involving all thematic priorities of ERA shows the reduced number of accepted projects coordinated by/or including Eastern European Countries (EEC). The conclusion for the Romanian participation in FP6 project, especially in IP and STREP is that the rate of success is far less than the average. The main reason of this inconsistent participation of Associated Countries, including Romania, is the lack of corresponding infrastructure and the expertise of personnel. Specific measures have been agreed according to Lisbon strategy, in order to reduce the differences in performance between Member States and Candidate States. However, the differences still remain important and are often acute in the case of EEC. In this r espect, the present call has a generous goal for Reinforcement of Research Capacities" of the three countries Romania, Bulgaria and Turkey, in order to contribute to the Europe cohesion by progressive reduction in the initial gap between EU and Eastern Eu rope region. The main objective of the present proposal is to reinforce the S&T potential and to enhance the capacity of the Polymer Department from ICECHIM to participate as a successful partner in ECFP projects. The targeted priority in ERA in partic ular the 3rd priority NMP, according with the previous research activity of the team and with the promising results obtained in former ECFP projects. In order to achieve the specific objects of the project, some relevant activities will be developed in a c oherent strategy of workplan, most of them involving the cooperation with relevant European Centres with similar preoccupations. The applicant institution represents a promising research institution, with national recognition, with potential and credibilit y. The p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European and north atlantic daily to multidecadal climate variability' (EMULATE).

assistant: **Innovation**

EMULATE proposes to create daily gridded fields of mean-sea-level pressure (MSLP) over the extratropical North Atlantic and Europe (25 degrees North to 70 degrees North; 70 degrees West to 50 degrees East on a 5 degrees by 5 degrees grid spacing), 1850 to date. The data will be used to develop time series of characteristic atmospheric circulation patterns for each season, sampled on sub-monthly time scales. Variations and trends in these patterns will be related to those evident in large-scale sea surface temperatures (SSTs) and other possible oceanic fluctuations including those of the thermohaline circulation, with the aid of atmosphere only and coupled atmosphere and ocean models. Variations in the incidence of extremes of temperature and precipitation across Europe will be related to fluctuations and trends in the atmospheric circulation patterns on daily to multi-decadal timescales and, for temperature, to SST and possible anthropogenic factors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Health benefits of exercise: identification of genes and signalling pathways involved in effects of exercise on insulin resistance, obesity and the metabolic syndrome' (EXGENESIS).

assistant: **Concept**

The European Union, like the rest of the world, is faced with an epidemic of the related chronic conditions, Type 2 diabetes, obesity and the metabolic syndrome. Unless steps are taken to alleviate this crisis, the cost of treating the long-term consequences of these conditions could overwhelm our healthcare systems. Although genetic factors increase the risk of developing these conditions, their rapid current global rise must be due to environmental factors. Obesity and insulin resistance, both precursors of Type 2 diabetes, arise due to an imbalance between energy intake and energy expenditure. This in turn may be due to two features of the modern urban lifestyle: (i) frequent consumption of processed foods with high energy and low fibre content; (ii) reduction in the amount of exercise taken due to changes in social and transport patterns. It is now well established that regular exercise, combined with an improved diet, provides protection against the development of these conditions, as well as a first line of treatment. The aim of the consortium is to provide a better understanding of the molecular mechanisms involved, especially in terms of the signalling pathways and changes in gene expression, that provide these beneficial effects of exercise. Our consortium will address these questions using a range of multidisciplinary approaches including:(i) molecular and cell biology;(ii) studies of animal models;(iii) physiological studies in human volunteers of both genders;(iv) epidemiological and genetic studies of large human populations of both genders.The consortium includes companies in the areas of food production, pharmaceuticals and biotechnology, who will ensure rapid application of the findings made. Improved understanding of the molecular basis of the beneficia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel Integrated Approach for Assembly Analysis of Intrinsically Disordered Proteins at High Resolution' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Protein aggregation hallmarks several neurodegenerative diseases, including Alzheimer's and Parkinson's. In Parkinson's, aggregation of the intrinsically disordered protein (IDP) alpha-synuclein (Syn) leads to its intracellular deposition into Lewy bodies, which causes neuronal dysfunction. Recently it was discovered that Syn can undergo liquid-liquid phase separation (LLPS), whereby a protein solution spontaneously separates into a dense and a dilute phase. This process is initially reversible, but the high concentrations of the dense phase strongly favor the aggregation of Syn into amyloid fibrils. Structural characterization of the transient Syn conformations during LLPS and amyloid formation is therefore crucial for understanding the disease pathology on the molecular level. This project aims to develop a novel experimental concept for the high-resolution conformational analysis of Syn assembly and aggregation using scanning mutagenesis combined with cutting-edge high-throughput biophysical techniques and computational analysis. The core idea is to apply multiple biophysical assays to quantify the effects of hundreds of Syn mutations on the kinetics and thermodynamics of LLPS and amyloid formation. The resulting multidimensional experimental datasets will be processed within the phi-value analysis framework originally derived for protein folding and combined with molecular dynamics simulations. The integrated methodology will allow gaining important structural and mechanistic insights into the early-aggregation events of Syn at a single amino acid level of resolution. The project includes extensive training to enhance my scientific skills in modern experimental and computational methods. The proposed strategy is widely applicable to other IDP systems that can underg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Novel molecular tools for the analysis of the cell membrane proteome and interactome' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The vast amount of data originating from the different genome initiatives in the context of systems biology require more and more emphasis to be placed on the elucidation of the different levels of dynamic processes present in the living cell. Beyond the transcription level (transcriptome), systematic analysis of the proteins expressed by a cell at a certain time and under certain conditions (proteome) is of eminent importance, as they are the major players in biological processes. Despite the fact, that many technological advances are currently involved in proteome analysis, there is still a great need for the development of novel molecular tools that permit or facilitate genome-wide proteome analysis or that allow for the tailored creation and analysis of proteome subsets.Retrieval of biomolecular interaction partners from the proteome results in the interactome" of a class of proteins or other biomolecules. The scientific goal of the training project is the development and application of novel engineered chemical probes for proteomics and interactomics. Focus is placed on the interaction of integrins and matrix metalloproteinases with each other and with other proteins, as both are potential target in tumour therapy. Small-molecule integrin ligands (RGD peptides) and matrix metalloproteinases (hydroxamate inhibitors), respectively, will be chemically modified to allow for the immobilisation of the ligands to magnetic beads or affinity chromatography materials. Proteins will be detected together with their native interaction partners because of the non-denaturing conditions.These new developments will play a major role on the contact points between chemical biology and systems biology, one of the biggest challenges of the next decades. The combination of promising and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Job creation in innovative relational services the case of services to private individuals' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The main objective is to study job creation in innovative relational services (IRS) consumed by private individuals. IRS create a virtuous circle increase of the activity rate, equalization of the activity rate among men and women, decrease of exclusion, increase of well being. We'll characterize the different models of job creation in IRS in 5 European countries; analyze trade offs quality/quantity of jobs in the different models, and the respective role of public sector, profit and non-profit sector. We'll compare the present ideal types and carry out a statistical analysis of the sector. A field survey will analyze the functioning of 80 IRS enterprises. We'll define new ideal types, elements of comparability of the described situations; see how to optimize the models and how good practice can be transferable. We'll present our results in a form that can be used for policy purposes and social partners. We foresee a large dissemination program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Large-scale interactions mediating cognitive processes: Non-linear and non-separable' (NONLIN).

assistant: **Concept**

The human brain's cognitive abilities arise from complex interactions among highly interconnected brain areas. We have recently argued that interactions between oscillations at the same frequency (coherence-through-communication) cannot fully explain this coordination, due to the heterogeneity in cortical oscillation frequency and amplitude, as well as rapid cognitive state changes linked to aperiodic transients. Instead, we propose that non-linear interactions, which enable pattern recognition and integration beyond simple information relaying, are essential for understanding large-scale integration. NONLIN will investigate how non-linear mechanisms coordinate large-scale cortical networks and mediate cognitive and brain state changes, and will determine the non-separable nature of information integration, where combined influences of multiple regions on a target area cannot be decomposed into independent effects, counter to traditional modular views of cognition. To move beyond bi-variate, linear measures like coherence and Granger causality, NONLIN develops new mathematical methods to isolate and characterize non-linear and non-separable interactions, separating them from linear correlations caused by simple linear information relaying. Using large-scale intracranial electrophysiological data from humans and non-human primates, NONLIN will analyze how non-linear interactions reflect whole-brain anatomical connectivity and exhibit emergent properties distinct from the linear functional connectome. NONLIN tests whether active, alert states enhance non-linear, non-separable information integration, and whether cognitive processes, including attention, working memory, and perceptual binding, are primarily mediated by transient, broad-band influences and cross-frequency i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing a novel peptide-based therapeutic for pancreatic cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Pancreatic cancer is a devastating disease with a median 5-year survival rate of 3-5%. One explanation for the dismal prognosis is the failure of many chemotherapies. Pancreatic tumor cells stimulate neighbouring non-tumor cells (stromal cells) to join and grow around them. This stroma forms a fibrous matrix that promotes 1) aggressive tumor growth, 2) distant metastasis, and 3) form a barrier to chemotherapy and drug delivery. There is a high need to enhance the success of pancreatic cancer treatment by intensively pursuing strategies that target the tumor stroma. We are developing a novel peptide-based drug (AV3), that targets and reduces tumor stroma in pancreatic cancer, and potentially in other fibrosis-associated cancers. We have demonstrated that AV3 reduces fibrosis (>50%) and enhanced the efficacy of chemotherapy in clinically relevant patient-derived xenograft models (achieving up to 80% tumor regression). Thus, our novel peptide has the potential to become a breakthrough add-on to chemotherapy in the treatment of pancreatic cancer. We are a biopharmaceutical company, spun-out in 2016 by the University of Twente. Our mission is to develop novel, targeted, peptide-based drugs to treat pancreatic cancer and other fibrosis-associated cancers and diseases with high unmet medical needs. The management team consists of its pioneering scientific founder and inventor of the technology Prof. Jai Prakash (CEO) and an experienced entrepreneur and drug developer Dr. Bart Metselaar (COO). The FIBROHALT project will (1) create a clear overview of the clinical opportunity for AV3 in pancreatic cancer, 2) develop a strategy to position the drug in the pancreatic cancer market, and (3) create an optimal development strategy, including a de-risk plan for future clinical studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Experimental Analysis of Framing Effects via Observation of Decision-Making Processes to Improve the Real-World Applicability of Decision Research in Economics' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Fellowship objective is to explain influences of descriptive context on individual decisions, i.e. framing effects, by observing processes of making-sense (of representation/interpretation/rationalization). Experimental Economics ignores effects of framing on this “black-box” of decision-making processes, and instead theorizes framing by observing only choices & using fixed preference structures. This not only limits our understanding of these effects but weakens real-world applicability of experimental results & leads to inefficient use of public funds; e.g., it is well-established that descriptions used in policy tools, e.g. contingent valuation (CV) & nudging, significantly affect results, yet it is unknown why or how. To unpack this box, fellowship at U. of Nottingham’s Centre for Decision Research & Experimental Economics (CeDEx) will combine Dr.Isler’s background in methodology research with training/research on framing to develop 2 new experiment designs. Secondment at Leeds U. Centre for Decision Research will enable training on Process Tracing Methods (PTMs) & Mouselab software to provide capacity for process observations. Using PTMs/Mouselab in experiments at CeDEx, 1st design will isolate framing effects that choice/preference-based conventional theories cannot explain; 2nd design will analyse these effects in CV-like public good setting to develop probabilistic/structural model to forecast & PTM-based nonconventional theory to explain the effects. To allow sector/policy applications of lab results (e.g., to CV), designs will be used in field experiments at health/fundraising SME secondments, where training on patient/donor interaction & gender/ethics issues will prepare proper implementation. Fellowship’s training-through-research will thus launch a career i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'WING BOX TECHNOLOGY EVALUATION  - TRADE-OFF STUDY FOR THE RANKING OF NEW TECHNOLOGIES BEST FITTING WING'.

assistant: **Objectives**

The activities encompassed in this proposal, aimed to provide a trade-off study between a reference wing stub box design and alternative advanced designs of the same structure incorporating new technologies, will exploit a methodological approach, which will allow to efficiently solve the simulation problem, by tackling all possible issues related to management of the geometries, definition of a high-quality mesh, application of specific composite material behavior laws,  up to loading, solution and post-processing.The advanced character of the forecast approach is linked to the following aspects:-  the complete modeling process will be integrated into a parametrized global process flow that, under the control of the Multi-Objective Optimization algorithms implemented within the modeFRONTIER tool, will allow a quick and complete exploration of the influence of the parameters that can influence the system performances;- the complete set of analyzed models will be explored (again using the modeFRONTIER tool) to rank them with respect to their key performances and to select the optimal candidate(s) considering the multiple selected objectives, by exploiting the mostly advanced Multi Criteria Decision methods.