RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Use of PAP as a biomarker and stratifier of pancreatic cancer to improve patient management'.

assistant: **Concept**

With an overall 3-year survival rate of only ~6% together with an increased incidence pancreatic ductal adenocarcinoma (PDA), which represents 90% of pancreatic cancer, figures as the solid cancer with the worst prognosis. In trying to understand “the” reason for such negative outlook, one has to consider that the fundamental and clinical research conducted during the last 30 years has focused on characterizing and understanding the properties of the PDA cancer cells, neglecting the specific cellular context of those tumors. Indeed PDA consists of 80% of non-tumor cells. In the ERC Starting grant, S-Target-in-PANR, I conducted from 2011 to 2016 we took into account this specificity and analyzed the impact of this stromal compartment on PDA physiology. The discoveries and conceptual progresses obtained throughout the S-Target-in-PANR programme opened new potent improvements of PDA patients’ management. Among them, we revealed that one of the candidates, PAP/REG3A, was secreted by acinar cells from the peri-tumoral microenvironment to enhance peri-neural invasion ability of tumor cells. Interestingly, we demonstrated that PAP/REG3A titration in serum was a potent biomarker in order to stratify PDA and could lead to patients’ management optimization and more specifically to predict resectability. This validation, using robust cohorts and adapted testing, constitutes the main goal of our ERC-PoC pBioStrat-for-PDA. Indeed, it will provide a powerful tool for clinicians in order to better determine the resectability of a tumor by taking into account its biological nature on top of the only clinical criteria used so far. As a consequence the use of a non-invasive PAP/REG3A serum level determination will improve patients’ managements by (1) shortening the delay to start palliat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reference measurements for agricultural, food and consumer products and data Bases' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Specific Objectives- Development and validation of analytical methods for several families of compounds in food matrices: antibiotics, selenium species, sugar analysis in industrial syrup, radio nuclide determination;- Analytical method development and validation for selected proteins and metal-binding proteins of high interest;- Support for the implementation of cosmetic Directives: European reference method for oxidative hair dyes.Planned Deliverables- Specific Deliverables to DGs;- Validated method for sugars in industrial syrups (DG AGRI);- Validated method for oxidative hair dyes in cosmetic formulations (DG ENTR);- Measurement of selenium species in reference materials (DG RTD, IRMM Reference Materials unit);- Deliverables as a result of the research;- Validation of methods for quinolone antibiotics in meat samples;- Participation to the certification of selected proteins in clinical samples.Summary of deliverables made by: 31/12/2001Oxidative Hair Dyes EC Directive: 76/768/EEC DG ENTR.This research is required for the implementation of the Cosmetic Directive through harmonisation of analytical methods. At the 17th plenary meeting on 12.06.01 of the Scientific Committee on Cosmetic and Non-food products, a population based control study showed a significantly increased risk of bladder cancer among long-term regular users of hair dyes.On discussions with the working group Methods of Chemical Analysis of Cosmetics", 5 commercial formulations (3 shampoos, 2 creams, blond and brown shades) and 16 oxidative hair dyes were proposed for complete validation with a maximum of 8 in a formulation. Change of the sample preparation and re-optimisation of the LC-DAD method was completed as well as quantifying the maximum deviation in concentration for each formulation.Final in-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Self-organized biomolecular gradients for controlling cellular behaviour in cell culture' (SOCELL).

assistant: **Concept**

Concentration gradients of biomolecules are essential in important biological events such as morphogenesis, inflammation, wound healing and cancer. As a consequence, devising methods to generate highly controlled biomolecular gradients for studying cellular behaviour is a major scientific endeavor. However, state-of-the-art approaches based on microfluidics suppress cellular signalling by washing molecules away, limiting their biological significance. To solve this issue, this proposal will develop an original method to create biomolecular gradients that influence cellular behaviour without interfering with cellular communication. This method relies on recent DNA nanotechnology developments in the host group that create complex ssDNA concentration gradients autonomously, through a reaction-diffusion mechanism. The goal of this proposal is to demonstrate that such self-organized concentration patterns of DNA strands can modify the gene expression of human cells in vitro. Antisense technology will be used to couple extracellular DNA gradients with changes in cellular behaviour. As a proof of principle, a two-band concentration pattern of DNA will be created, which will induce in vitro a similar pattern of fluorescent protein expression on a HeLa cell monolayer. As an application, biomolecular gradients will be used to control wound healing assays, allowing the patterning of cell culture. These results would open doors to control and study cellular behaviour while maintaining crucial cellular communication mechanisms. In the long run, this technique, that combines the self-organization of synthetic molecules and living cells, could be advantageously used in tissue engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Advanced hearing aid test tools in Oticon'.

assistant: **Innovation**

- To achieve a threefold improvement in test throughput with corresponding cost reductions.- To achieve easy transfer of results from design verification to production test.- To integrate a more user-friendly testing environment.- To adapt the prototype tool to the user needs.- To increase the vendor confidence in the market for the tool.- To disseminate the results throughout the community.HEARMASTER is a Demonstration Project which demonstrates the introduction of advanced mixed-signal test techniques and tools in a leading manufacturing company of hearing aids. By introducing modern Digital Signal Processing (DSP) test techniques the envisaged improvement in throughput during testing can be increased threefold compared with the existing system for test. To cater for such improvements a certain amount of tailoring will be needed to comply with the demands of the user.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of the cellular sites of cytomegalovirus latency that contribute to the induction of inflationary CD8 T cell memory against the virus.' in the context of a Horizon 2020 call.

assistant: **Objectives**

T cell memory is the cornerstone of protective immunity and the key determinant of the efficacy of vaccination approaches. Memory inflation (MI) is a unique type of CD8+ T cell memory characterized by the induction of robust and durable populations of functional effector/effector memory CD8+ T cells that is elicited by latently persistent cytomegalovirus (CMV) infections. Accumulating evidence argues that inflationary T cells can provide exceptionally strong immune protection. Hence, several translational approaches involving MI, such as CMV vector-based vaccines, are subject of ongoing pre-clinical and clinical projects. Despite this, little is known about the cellular and molecular mechanisms governing the induction and maintenance of MI. In this proposal, I aim to identify and characterize the latently infected cell type/-s, which sustain CMV-specific inflationary CD8+ T-cells. To this end, I will combine state-of-the-art stromal cell characterization and isolation techniques with generation of novel recombinant virus-based in vivo models enabling (1) tracking of latently infected cells, (2) conditional ablation of viral peptide processing in selected cell types. The results of this action are expected to improve our understanding of the mechanisms and requirements for MI, laying the basis for the development of improved vaccination strategies. Furthermore, identification of the sites of CMV latency in vivo will have implications for development of future clinical strategies aimed at harnessing the ability of CMV to reactivate in immune suppressed patients. Thus, this proposal explores a basic biological question of broad general interest, but also has robust translational potential for applications in human medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Computational study of on-surface catalysis induced by ligh' to be submitted under Horizon Europe.

assistant: **Abstract**

On surface synthesis is an emerging field that aims to adapt traditional organic chemistry reactions to the fabrication of atomically precise low-dimensional nanostructures. This has been made possible thanks to the catalytic properties of surfaces and their 2D confinement. Despite the rapid development of this field, there are still key fundamental aspects that require additional efforts. One of the main problems is the strong interaction of nanostructures with the catalytic metal surface that results in a real impeachment for applications due to the difficulty of decoupling the nanostructures from the surface. To solve this, the community, and the host group, have turned its attention to the use of photoreactions on an insulator for the formation of these nanostructures and low-dimensional materials without the use of thermal catalyzed processes on a metal surface.The scientific objective of this fellowship is to develop computational tools to rationalize, and finally predict, possible photochemical reaction pathways of organic molecules deposited on surfaces. In particular we have three main objectives: create a virtual screening method for the study of molecular self-assembly on surface; study the effect of surface, substituent and self-assembly in the absorption spectrum of the molecule and a computational study of the photo reaction that can takes places on the surface.  For these objectives we will  take advantage of the computational tools developed during the phD and postdoc of the applicant  for others fields, like biochemistry and wet chemistry, and apply them and develop new ones for the field of on-surface photochemistry together with the host-group . This synergistic approach, together with the experience and facilities of the host and collaborators, will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Energizing microbes with redox mediators for new bioproductions' under Horizon 2020.

assistant: **Concept**

In many bioprocesses a broad bioproduct portfolio can currently only be obtained when microorganisms can access oxygen as an electron acceptor. For numerous target substances, however, oxygen is detrimental to product stability and the bioprocess operation. The central aim of e-MICROBe is to innately couple microbial metabolism and electrochemistry via a self-secreted soluble electron mediator to achieve efficient oxygen independent energy metabolism and to directly steer and control metabolism and product formation. This will require creating entirely new physiological traits for production and utilization of redox mediators to generate cellular energy. Thereby, mediators can either act as electron discharge shuttle to enable electro-respiration at an anode or they are employed as inorganic energy donor to deliver electrons from a cathode into the metabolism. We will clarify the underlying reaction pathways in known environmental microorganisms and re-engineer the energy metabolism of common biotech hosts. Thereby, we will switch cellular energy generation from aerobic respiration to anaerobic anodic electro-respiration or from hydrogen consumption as autotrophic electron donor to cathodic electron consumption. The latter process will provide a mechanism to store electrical energy in microbial products. For a new level of in situ insight into microbial energy metabolism, a novel micro-scale bioelectrochemical reactor coupled to microscopic observation and high performance analysis will be developed. With this technique two fundamental concepts for future mediator-based bioprocesses will be evaluated: An all-in-one strategy where one cell is generating the mediators and the targeted product as well as a co-culture system, whereby one cell produces the mediators and a pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electrochemistry of All-solid-state-battery Processes using Operando Electron Microscopy' under Horizon 2020.

assistant: **Concept**

All-solid-state batteries(ASSB) enabled by electrochemically stable solid electrolytes represent a promising alternative to the conventional lithium batteries with liquid electrolytes which jeopardize battery safety.  However, the complex charge transfer at solid-solid interfaces greatly limits the electrochemical performance of ASSB. Therefore, a detailed understanding of how the morphology, structure and chemical composition changes at the electrode-electrolyte interfaces and within the solid electrolyte particles and/or across grain boundaries on battery cycling is urgently needed.In this project, I will utilize operando transmission electron microscopy(TEM) and scanning electron microscopy(SEM), to visualize the morphological, structural and chemical changes across electrode-electrolyte and electrolyte-electrolyte interfaces during battery cycling to develop new insights into ion transfer mechanisms at the atomic scale. For this, utilizing one of the best TEM facilities in the world including the expertise of TEM specialists and availability of sophisticated TEM specimen holders at the Ernst Ruska-Centre in Forschungszentrum Jülich, with state-of-the-art battery materials and battery engineering at Imperial College London and my expertise in designing and performing operando TEM battery studies,  I will construct all-solid-state micro-batteries inside TEM and visualize morphological, structural and chemical changes at battery interfaces during (de)lithiation and compare these with that of liquid electrolytes to determine the best battery architecture. To evaluate how such nanoscale processes impact the performance of lab-scale ASSB batteries, SEM-based cells will be employed. The understanding of interfacial processes that dictate the potential of ASSB and new strat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Opticon RadioNet Pilot' under Horizon 2020.

assistant: **Concept**

For more than two decades, the EU has been supporting free transnational access (TA) to existing national research infrastructures (RI).   In particular, the optical/infrared and the advanced radio astronomy communities are now recognised as TA flagship communities. Their telescopes and instrumentation complement each other with respect to wavelength coverage, as well as spectral, spatial and time resolution, and therefore together form a cohesive suite of RIs that made ground breaking discoveries possible and thus strengthened Europe's leading role in international science.   While scientists more and more rely on multi-wavelength and multi-disciplinary access to the best RIs, there is a quest by the RI providers for a sustainable funding scheme for TA, since establishing and maintaining outstanding RIs requires considerable resources.  In this pilot, the best research institutions from both communities will combine their efforts to further improve and harmonize their services and to make best use of their RIs, allowing mutual and TA to telescopes, telescope networks, and data archives. This will facilitate multi-wavelengths and time-domain studies. TA shall be simplified by the development of a common proposal submission tool. Improved instruments, adaptive optics, and software to deliver science ready data products will boost the performance of our RIs. This pilot will address imminent threats to astronomical research from satellite mega constellations and commercial radio emitters, and finally, it will develop plans for a long-term mutual relationship and for a continued funding of TA beyond this pilot.


**Keywords:** Optical astronomy, Radio astronomy, Astrophysics, Physics, Research Infrastructures, ground-based telescopes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Politics, Institutions, and Production Networks' (PINPOINT).

assistant: **Concept**

What are the political sources and consequences of economic globalization, and how do political institutions shape globalization? Current frameworks for understanding the politics over economic globalization emphasize a fragmentation of politics: political conflict breaks down to individual firms and citizens, because the gains from trade are concentrated on large, globally engaged, and politically active firms. Departing from this view, PINPOINT develops an innovative framework built on the linkages between firms created by domestic production networks. Production ties imply a much broader impact of economic globalization, because many domestic firms interact with international markets indirectly as suppliers and as customers of globally engaged firms. Moreover, these linkages vary in quantity and quality. To date, we know surprisingly little about the role of production networks in politics, which creates a mismatch between the structure of modern economies and current theoretical frameworks. Ignoring such ties risks misattributing the impact of economic globalization, overlooking economic roots of political coalitions, and misunderstanding the sources and consequences of economic globalization. PINPOINT places economic exchange between firms front and center in an account of the behavior of governments, firms, and citizens in the context of international markets, and of the role of institutions in such an account. PINPOINT will provide theoretical and empirical innovations that lead to a revised understanding of the political underpinnings of economic globalization and of the mechanisms through which institutions shape economic globalization.


**Keywords:** production networks, trade policy, political institutions, firms, firm heterogeneity, international trade, ele