RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional relevance of mitochondrial supercomplex assembly in myeloid cells' (2014-2020).

assistant: **Concept**

The emerging field of immunometabolism has a strong potential to uncover novel targets for the manipulation of immune cell function. Myeloid cells are involved in innate and adaptive immunity and tolerance, therefore the identification of pathways that regulate their activity may have implications in many diseases. Research in the host laboratory has focused on how sensing of innate stimuli (infections and tissue damage) lead to mitochondrial adaptations in myeloid cells. These mitochondrial adaptations can influence the electron transport chain (ETC), resulting in differences in reactive oxygen species (ROS) production, ATP synthesis, redox balance and metabolites. The ETC consists of four respiratory complexes (CI-CIV), which can, excluding CII, form super complexes. The formation of these super complexes is regulated and this regulation has been shown to have biological relevance. However, whether mitochondrial SC organization couples to regulation of immune cell function and the molecular mechanisms involved is not known. Therefore, we propose to investigate how mitochondrial SC formation affects macrophage and dendritic cell function. Identification of the mechanisms connecting mitochondrial adaptations and myeloid cell function could potentially unveil therapeutic targets. Much immunometabolism studies could be improved by in vivo models, therefore we aim at studying the effects of SC formation regulation in vivo. We intend to use targeted and non-targeted approaches to address this question. A mouse model that exhibits a non-active SC assembly factor (SCAF1) will be a key tool to address this question in vivo. The non-independent approach includes state-of-the-art metabolomics and transcriptomics.


**Keywords:** Dendritic cells, immunometabolism, mitochondria, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Translational Research on Endometriosis' (TRENDO) targeting Horizon 2020.

assistant: **Abstract**

Endometriosis is a sever disease affecting 10% of reproductive age women, characterized by the presence of endometrial-like tissue outside of uterus. Due to the associated pain, inertility and a small, but increased risk for developing ovarian cancer, its socioeconomic impacts are considerable, and have a profound effect on women’s mental and physical health. Endometriosis is characterized by a diagnostic delay of a decade, as its diagnosis is surgery-based, and all attempts to identify the non-invasive biomarkers have not been progressed beyond the discovery. Moreover, current treatments include only surgery or hormonal medications with significant side effects. In view of the above, the endometriosis care is challenging, and is hampered by the considerable heterogeneity of clinical manifestations. TRENDO consortium addresses the main problems in endometriosis diagnosis and therapy in a multidisciplinary and trans-sectoral effort, bringing together the clinical and translational science experts, and industry partners from six European and South American countries. We develop non-invasive biomarkers and testing, which shorten the diagnostic delay, and reduce the unequal access to expensive healthcare. These biomarkers are tested for the suitability as drug targets, to monitor treatment response, and to predict the personalized clinical recommendations. By combining the strengths of our partners, we provide novel tools addressing the most urgent priorities in endometriosis and to successfully translate our findings into novel therapeutic approaches. This challenging scientific task provides an ideal career-enhancing setting for young scientists, providing them with transdisciplinary and trans-domain training, and with essential transferable skills. The training program p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SCALING UP OF THE MEDUNIVERSE PATIENT CASE ENGAGEMENT PLATFORM'.

assistant: **Concept**

Every interaction with healthcare professionals (HCPs) presents the Life Sciences (LSci) industry with opportunities to deliver and derive value. However, the low level of digital maturity prevalent in the sector means that often these opportunities don’t materialise. The manner in which new treatments are communicated and how feedback regarding these is gathered is a clear example of this problem. Current approaches fail to engage HCPs and to gather data in a systematic manner.  With this problem in mind, we developed MedUniverse - a patient case engagement platform that helps the LSci industry communicate with HCPs in an engaging manner which captures relevant quantitative data and delivers reliable results. In the platform, HCPs interact with simulated patient cases, gaining feedback on their responses and viewing how their understanding compares to their peers. The interaction data is then presented in a dashboard for our customers to gain insights into the effectiveness of their medical education and multi-channel marketing campaigns.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EUROPEAN LABOUR MARKETS UNDER PRESSURE – NEW KNOWLEDGE ON PATHWAYS TO INCLUDE PERSONS IN VULNERABLE SITUATIONS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

PATHS2INCLUDE will provide new, gender-sensitive, comparative knowledge-base on effective employment policies targeted at developing inclusive labour markets for persons in vulnerable situations in Europe. The study will examine the importance of intersectionality related to how context creates vulnerability, by focusing on three central labour-market processes: recruitment; career trajectories; and work exit. Through the involvement of national and European stakeholders, PATHS2INCLUDE aims to develop proposals for effective policies and to inform relevant policymakers with a view to maximising the project’s impact from a societal as well as scientific perspective. The project will combine diverse methods, data and disciplines (economics, political science and sociology) in innovative ways: (1) harmonised factorial survey experiment combined with qualitative interview studies with employers in four European countries (DE, NO, PL and RO); (2) causal analyses of comparative microdata; (3) microsimulation analysis exploiting the EUROMOD infrastructure. Linking the analyses of these data and the three central labour-market processes, will give original insights on how institutional and contextual factors shape barriers or mitigate risk of labour-market attachment among persons in vulnerable situations. These insights could include cross-national differences in employment-protection legislations and facilitation of care, regional differences in demand for labour, differences at company level related to the size of the firm, flexibilities in job tasks, and conditions that were affected by the COVID-19 pandemic, covering unemployment rates and infection-control measures across different segments of the labour market. The project will be implemented by an interdisciplinary cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Discovering the Deep Mediterranean Environment: A History of Science and Strategy (1860-2020)' in the context of a Horizon 2020 call.

assistant: **Objectives**

Few geographical spaces have been more relevant to human life and more intensively theorized than the Mediterranean Sea. Today, this sea poses some of the most pressing challenges and opportunities for European economic, security, and environmental policies. Answers to how to manage the region depend on ideas and perceptions of integration and division of the basin and its peoples. But the Mediterranean as a spatial concept has radically changed in the last 160 years as humans have gained access to its depths, unveiling an underwater world to discover, exploit, and navigate. The Mediterranean has become a volume. DEEPMED is the first historical account of the discovery of the deep Mediterranean environment. Its main hypothesis is that science and strategy jointly made the Mediterranean depths into an object of analysis and a political space, which in turn shaped science and strategy in the region. DEEPMED pursues three specific objectives: 1) identifying the actors and contexts that enabled perceptions and practices of depth in the Med; 2) describing how natural and human time-scales interact in this body of water, and 3) tracking key conceptual landmarks defining the uniqueness and representativeness of the Mediterranean volume vis à vis the global ocean.  DEEPMED is the first basin-scale step in a novel approach to oceanic history that incorporates analyses of deep and bottom layers of the Sea to gauge the causes and effects of the historical emergence of depth. This requires an innovative interdisciplinary, transnational and digital methodology. The project identifies overarching trajectories of human engagement with Mediterranean depths from the mid-19th century to the present, including contrasting timelines and perspectives. The availability of digital tools for c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'COmbined suN-Driven Oxidation and CO2 Reduction for renewable energy storage' (CONDOR).

assistant: **Innovation**

Conversion of sunlight into fuels and mitigation of anthropogenic climate change are big scientific challenges. CONDOR addresses both of them by developing highly efficient solar-driven conversion of CO2 into fuels and added-value chemicals. We propose a photosynthetic device made of two compartments (a) a photoelectrochemical cell that splits water and CO2 and generates oxygen and syngas, a mixture of H2 and CO; (b) a (photo)reactor that converts syngas into methanol and dimethylether (DME), via bi-functional heterogeneous catalysts. The proposed modular approach enables different configurations depending on the target product. The oxidation process is not limited to O2 production, but entails chlorine and small organic molecules, such as 2,5-furandicarboxylic acid, derived from the oxidation of low-cost and easily available precursors like salt water or alcohol derived biomass, respectively. Employed materials will be obtained through low energy/low temperature routes, mainly based on wet chemical procedures, such as sol-gel chemistry, mild hydrothermal processes, electrochemical processes at ambient temperature. Raw materials/precursors will not be limited by availability on a global scale, making use of organic species, silicon, earth abundant metal oxides, first row transition metals. The final target is a full photosynthetic device with 8% solar-to-syngas and 6% solar-to-DME efficiencies with three-months continuous outdoor operation. This represents a large progress with respect to the state of the art and requires an international collaboration and a multidisciplinary approach, which integrates expertise in nanomaterials preparation and characterisation by operando microscopy and spectroscopy, homogeneous and heterogeneous catalysis, photochemistry/photoelectroc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engineering cowpea mosaic virus-derived replicons for the expression of heterologous peptides and proteins in plants' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The aim of this project is to use virus-based systems which combine the advantages of viral vectors (e.g. high yield) with those of stable genetic transformation (e.g. no size limits on the protein expressed) as a novel approach to the high level expression of heterogonous proteins in plants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Root oxygen dynamics and its impact on development and physiology' (BreathingUnderground) targeting Horizon Europe.

assistant: **Abstract**

Roots play an essential role in plant growth by absorbing water and nutrients from the soil. As roots penetrate deeper into the soil, they encounter naturally decreasing oxygen levels, which can be exacerbated by soil structure and water content. With the increasing frequency and severity of floods due to climate change, these oxygen limitations (hypoxia) pose a growing threat to global food security because roots require oxygen for respiration, which is vital for efficient energy production. In addition to external factors, my previous research showed that internal factors can create hypoxic niches within root meristems, even in oxygen-rich environments. This pioneering study has begun to uncover a new area of research, highlighting the dynamics of root oxygenation and the consequences of inadequate oxygen supply on root architecture.BreathingUnderground now sets an ambitious goal: to discover how roots breathe beneath the surface and the impact this has on their development and physiology. We will explore: 1) oxygen distribution in root tissues; 2) the impact of chronic hypoxia on root development; and 3) the ability of roots to sense and grow towards oxygen-rich zones. This holistic approach aims to revolutionise the way oxygen provision feeds into root architecture, using advanced microsensors, orthogonal biosensors, X-ray tomography, and spatial transcriptomics. This project aims to create a high-resolution 3D map of root oxygen distribution by precisely measuring root zone oxygenation in natural settings. The project will reveal how oxygen acts as a diffusible signal to monitor root barrier integrity, regulate vascular development. Finally, it will uncover the mechanisms by which roots perceive and respond to fluctuations in oxygen. This fundamental knowledge can
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'S-6000 Dual Transceivers: Flexible and Robust Data Links On-the-move' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

S-6000 Dual Transceivers are miniaturised data links designed to provide reliable wideband communications for critical platforms on-the-move, with the best price-performance ratio in the market.The number of critical applications requiring reliable data links under high-dynamic conditions is increasing. The market need and growth is led by RPAS. With a huge market potential for infrastructure surveillance, firefighting, disaster or environmental monitoring, as well as border control and management, RPAS have been earmarked as one of four capability development priorities by the European Council. Other platforms such as Space Launchers, Balloons, Autonomous Vehicles or Maritime Facilities also require high-performance links with similar characteristics. However, solutions providing reliable high-speed data rate and long range communications on-the-move, are very expensive and they are only commercialised under hard export regulations for defence applications. S-6000 Dual Transceivers will provide a high-performance solution at a reasonable price closing an existing gap in the market, between expensive and export regulated systems and unreliable links for consumer applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Effects of ALAN on lunar biology at sea: Characterization of sensory-neurosecretory cell type plasticity in adult Platynereis dumerilii from protected and light polluted areas' (BrightPlaty) under Horizon Europe.

assistant: **Objectives**

In recent years, researchers have increasingly focused on the effects of artificial light at night (ALAN) polluIn recent years, researchers have increasingly focused on the effects of artificial light at night (ALAN) pollution on behavior and physiology of many terrestrial and marine organisms. ALAN particularly interferes with the circadian and circalunar rhythms, which are used to coordinate reproduction in many ecologically important marine organisms, such as brown algae, corals, and annelids. The bristle worm Platynereis dumerilii has been established as a leading model organism to characterize the process controlling circadian and circalunar rhythms. Recent studies by the Raible and Tessmar-Raible laboratories (Vienna, Austria) revealed the temporal plasticity of a specific cell cluster in the adult worm brain, which is thought to orchestrate lunar rhythms. However, this intriguing discovery was made under laboratory conditions, prompting further investigation into how this translates in wild animals and whether it is affected by ALAN. This project will be hosted in the Tessmar-Raible (TR) lab at the Max Perutz Labs (MPL) - University of Vienna (Univie), Austria, and it has three objectives: (1) to obtain a complete atlas of the cell types showing lunar plasticity in P. dumeriliis brain by performing the single-cell transcriptomic experiment over the course of two lunar cycles; (2) to characterize the cell type plasticity in wild P. dumerilii; (3) to identify the effects of ALAN on such response. These objectives represent significant advancements in the field, as the plasticity of cell types in response to lunar and circadian cycles is poorly understood and has been rarely explored using single-cell sequencing. Additionally, integrating data from wild specimens wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reducing supply chain impacts: The role institutions such as country, region, industry and ISO standards in the efficacy of environmental investments' (SSCM).

assistant: **Concept**

This research addresses a vital issue facing all organizations; how to remain economically viable while becoming environmentally sustainable. In addition, the research leverages a data base of investments and practices from for-profit entities located all over the globe. Data from multiple countries and regions is vital because the manner in which organizations from different parts of the globe address environmental issues tends to vary, with organizations located in the EU adopting different strategies and practices than those located elsewhere. What is not known is if this variance also relates to the efficacy of investment and practices. Without a global sample it is then impossible to determine if an investment and or practice is universally linked to reduced environmental impacts, or if the efficacy of an investment and or practice is linked to the setting in which it is adopted. This project will help to make this delineation clear. A Fellowship for Dr. Pagell will make it possible to do this research. Dr. Pagell is an expert on sustainable supply chain management (SSCM), in a North American context. The fellowship would bring Dr. Pagell and his knowledge to University College Dublin (UCD). There his skills and knowledge would be combined with the skills and knowledge of the UCD community as well as EU organizations engaged in SSCM. The project team will then combine global expertise and a unique data set to address this pressing issue. The project will use a data-base with detailed information on the actual environmental investments and supply chain management practices of 1125 firms located in 17 countries to explore the role of institutions such as country, industry, and the adoption of voluntary standards such as ISO 14,000 in the efficacy of investments made