RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel immunotherapies for tuberculosis and other mycobacterial diseases' (ITHEMYC) targeting Horizon Europe.

assistant: **Abstract**

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, Mycobacterium tuberculosis (Mtb; except in 2020-2022, when it was surpassed by the COVID-19 pandemic), with 1.5 million deaths in 2020. The lengthy TB treatment and the numerous adverse events contribute to poor medical adherence and development of antibiotic resistant strains. Thus, novel therapeutic modalities are urgently needed to shorten treatment duration, improve outcomes and control the emergence of drug resistant TB. The ITHEMYC project convenes a multidisciplinary consortium of 11 partners, including two Product Development Partnerships (TBVI, TB-Alliance) and an industrial partner (GSK) involved in vaccine, drug and biomarker R&D for TB. The partners will work jointly to develop innovative adjunctive TB immunotherapies by capitalizing on a promising pipeline and recent developments in the field. The project will combine current and new antibiotic regimens with novel immunotherapies, such as small molecules targeting host pathogen-interactions, including host-directed therapies and virulence inhibitors, immunomodulatory compounds, monoclonal antibodies and therapeutic vaccines. The project will generate robust preclinical safety and efficacy information on compounds and combinations through a set of relevant in vitro, in vivo and in silico models, and progress two of them up to preclinical proof-of-concept in non-human primates within the project duration. The partners are proposing a critical path for characterization and progression of immunotherapies, that will be refined based on knowledge generated in ITHEMYC aiming to increase the understanding and interest for this emerging concept of adjunctive TB immunotherapy. We expect the new combined interventions will improve TB cure r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PRicing REgimes fOr inteGrated SuStainable mobility' in the context of a Fifth Framework call.

assistant: **Objectives**

The overall objective of the PRISM proposal is:- to demonstrate and evaluate the effectiveness and acceptance of integrated urban transport pricing schemes to achieve transport goals and raise revenue.- To meet this objective the proposal centres on two demonstration sites building up new and comprehensive road pricing schemes, Bristol and Rome, supported by an additional site with existing charging infrastructure and long term experience, Trondheim.All three sites have strong political commitment to the concept of road pricing as a tool to support sustainable transport policies, and provide ideal testbeds to research pricing policy.The sites will work together in the PRISM project to demonstrate a range of integrated pricing regimes including:- an electronic road pricing schemes based on a single central cordon in Bristol;- a per-trip pricing scheme based on an existing access to control area in Rome;- a zone based electronic road pricing scheme in Trondheim;- tarif structures differentiated by:.time of day,.user and vehicle type.location and,.environmental conditions;- integrated payment for road pricing, public transport and parking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PROTAC-driven Protein degradation by Proteasome during Antigen Processing and Presentation (ProAPP)' (ProAPP), addressing dissemination and exploitation.

assistant: **Impact**

PROteolysis TArgeting Chimera (PROTAC) is a new and attractive therapeutic approach that regulates a target protein by channeling it to the proteasome for degradation (an energy-demanding pathway). Concurrently, proteasomes also play a central role in generating the peptide repertoire for antigen presentation on the Human Leukocyte Antigen-I (HLA-I) molecules. A few years after PROTAC was invented, proteasomes were found to catalyze not only canonical peptide bond hydrolysis, but are also capable of “cut-and-paste” events, i.e. generating spliced peptides, which have been shown to be frequently presented n HLA-I immunopeptidomes. It is unclear how PROTAC-driven proteasome degradation modulates the spliced and non-spliced peptide repertoire derived from a targeted protein. Alterations in peptide variety and quantity produced by proteasome may lead to strong implications on the HLA-I immunopeptidome, and, hence, could result in immune implications. Therefore, using the key oncoprotein KRAS as a PROTAC’s target, this study intends to understand: (i) how PROTAC-driven KRAS degradation affects cellular pathways on a system-wide level; (ii) the impact of PROTAC on KRAS derived peptide repertoire generated by proteasomes; (iii) to what extent PROTAC enhances KRAS derived peptide presentation on HLA-I molecules. Through the combination of a multidisciplinary approach; molecular biology, biochemistry, proteomics, bioinformatics and cellular immunology, this study will provide a better fundamental understanding of the effect of PROTAC-KRAS on the cellular proteome, proteasome-derived peptide repertoire (spliced and non-spliced peptides) and HLA-I immunopeptidome landscape, thus, provide insights into the suitability of PROTAC-KRAS application as a therapeutic approach for anti-ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Supersolids: unveiling an extraordinary quantum phase of matter' (Supersolids).

assistant: **Innovation**

Supersolids are a paradoxical quantum phase of matter that combines the properties of superfluids and crystals, searched for long time in quantum solids and many other systems. Recently, we discovered a novel cluster phase in a quantum gas of magnetic atoms which realizes a supersolid. However, the limited size, the inhomogeneity, and the lack of appropriate detection methods have allowed so far to assess only very basic properties of supersolids. Here I propose an innovative density-phase microscope and original ideas that combine the best of matter-wave and condensed-matter methods to unveil the extraordinary properties of supersolids. With a two-layer superfluid-supersolid configuration we will measure both density and phase of the supersolid. With controllable optical potentials we will realize large, homogeneous crystal geometries in 1D and 2D. With high-resolution optical addressing we will manipulate locally the wavefunction, e. g. creating phase patterns or force fields, and we will follow the local dynamics. Our main goal is to explore fundamental properties that are largely unknown even theoretically: variable superfluid density under rotation; variable angular momentum of quantized vortices; dissipation-less deformation of the crystal; Josephson effect without barriers; quantum entanglement properties. We will also attempt the realization of new types of supersolid, to prove the generality of the phenomena: with coupled supersolid layers, we will move towards supersolidity in 3D; using a quasi-2D environment, we will attempt to realize two proposed types of strongly interacting and strongly correlated supersolids.Our work will establish connections between supersolids and other patterned quantum phases, such as pair-density waves in superconductors and in hel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Expression and function of the new homeobox gen x3 during development of the mesencephalic dopaminergic system', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content The number of transcription factors with known discrete temporal patterns of regional and cell type specific expression in the developing vertebrate nervous system is rapidly increasing. The aim of this research project is to determine the properties and role of a new homeobox gene named X3 that has been cloned from rat brain in the host institution, in the development and maintenance of the mesencephalic dopaminergic system. The following studies will provide critical insights in X3 function during regionalization and cell-fate specification in the nervous system, and will be very useful to understand the molecular mechanisms regulating vertebrate neural development and degeneration or misdevelopment of the mesencephalic dopaminergic system, which relates to neurological and psychiatric diseases like maniac depression, schizophrenia and Parkinson disease. The proposed research plan focuses on several aspects of the X3 gene: It will determine the temporal relationship of expression of X3 and Nurrl (whose loss of expression causes agenesis of the mesDA system in mice). It will determine the transactivating and DNA binding properties of X3 on promoters of genes expressed in the mesDA, as well as its possible functional interaction with Nurrl. Its functional properties will be tested in knockout mice (ongoing project). Training content (objective, benefit and expected impact) The development of the present research project will allow the applicant to learn new techniques and acquire fresh knowledge in a field completely different from the previous studies realized during the PhD studies. Specifically, the results obtained from the proposed project on X3, may be exploited for manipulation of dopaminergic cells in vitro, in preparation of graf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Formal verification of mobile processes' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The research project concerns formal methods for the verification of mobile processes, i.e. concurrent systems whose communication topology may change dynamically. Propositional mu-calculus has emerged as a very adequate logic tor reasoning about classical concurrent systems. since it permits to naturally express all the interesting properties characterizing the correctness of these models. A very popular approach to verification for mu-calculus is given by local model checking and several proof systems (in tableau-like style) have been proposed for this purpose over the past few years. In contrast to classical algorithmic methods this approach may limit the drawbacks of state-explosion problem and it allows us to deal with infinite state systems. Moreover, it permits to introduce specific techniques, such those offered by the algebraic theories of processes, for realizing for instance compositional verification. The aim of this research is to study how these approaches to verification can be generalized to the mobile processes tramework. There are many interesting aspects to be investigated. First of all, propositional mu-calculus does not seem to be adequate for expressing all the properties concerning mobile processes, because of name-instantiation. Theretore, it should be studied a new more powerful version of mu-calculus and the corresponding local model checking problem for mobile processes, that are typically infinite. These results would be the basis for addressing the issue of compositional verification. Training content (objective, benefit and expected impact) The research concerns verification methods for mobile processes. Formal verification is an essential task in the mobile processes framework because of the typical complexi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding the role of intrinsic and extrinsic drivers of loss in species niches, to inform conservation planning under climate change' under Horizon 2020.

assistant: **Concept**

The extinction of species is the most alarming consequence of global biodiversity decline, with potential dramatic effects on our economy and well-being. The current rate of climate change is predicted to further increase extinction risk, hence there is urgent need to anticipate species decline rather than reacting to it. The breadth of a species’ niche - the set of environmental conditions in which the species can persist - is the key ecological trait that allows adaptation to environmental change, but is largely ignored in conservation planning applications. The goal of the PROTECTNICHE project is to disentangle the impacts of humans, climate change, and life history on the climatic niches of terrestrial mammals to inform a conservation strategy for preventing future species declines. This goal incorporates 3 objectives: i) Attribute the global change in past species climatic niches to intrinsic and extrinsic drivers; ii) Based on the models developed in Obj. 1, define a measure of adaptability to climate change for each species; iii) Based on the outcome of Obj. 2, develop a global conservation strategy to maximise the protection of species climatic niches while minimising their exposure to climate change. The project focuses on the world's terrestrial mammals, a data-rich group currently facing significant extinction rates, to develop and theoretically ground a conservation planning approach that can be also transfered to other taxa. Building on my expertise on extinction risk analysis and conservation planning, and the habitat and climatic modelling capabilities of Dr Rondinini and the Global Mammal Assessment lab, this project will define a proactive conservation plan where actions are prioritised to preserve species adaptive potential under global change. This is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Linking Ukraine to the European Research Area - Joint Funding and Capacity Building Platform for Enhanced Research and Innovation Cooperation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

LUKE is an initiative of several EU Member States and countries associated to Horizon Europe aiming to establish a multilateral funding and capacity building platform focusing on Ukraine. Its key objectives are to implement a joint call and fund transnational research and innovation (R&I) projects with Ukrainian participation as well as to enhance Ukraine's R&I capacities. A modern, efficient, and transparent science and innovation system is crucial for Ukraine’s post-war recovery and economic prosperity. Sharing best practices, pooling resources, and transferring knowledge can significantly contribute to unlocking Ukraine's scientific potential, improving the framework conditions for research and innovation, and integrating the country more closely into the European Research Area (ERA).The LUKE network comprises a group of funding parties and the project consortium responsible for accompanying activities. The overall coordination and management are conducted by a call secretariat. Altogether 19 organisations from 13 countries have already confirmed their willingness to participate as funders within the network: Austria, the Czech Republic, Estonia, Finland, Germany, Latvia, Poland, Romania, Switzerland, Ukraine itself, as well as the EU accession candidates Georgia, Republic of Moldova, and Türkiye. Additional funding agencies have expressed interest in joining and may be included in the group of funding parties once the joint call has been finalized. The project consortium includes nine organisations, amongst them the German Aerospace Center (DLR) as coordinator, the National Research Foundation of Ukraine (including the Horizon Office and Science Council), Centre for Social Innovation (Austria), Danish Board of Technology (DBT), and University of Daugavpils (Latvia).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Wave Energy Demonstration at Utility Scale to Enable Arrays' (WEDUSEA).

assistant: **Concept**

WEDUSEA led by Irish Wave Energy Developer, Ocean Energy, will demonstrate a grid connected floating wave energy converter (known as the OE Buoy) at the European Marine Energy Test Site (EMEC) in Orkney, Scotland capable of producing 1MW of renewable electricity from ocean waves. This rigorous technical and environmental demonstration will happen over a 2 year period in Atlantic wave conditions with outcomes directly impacting policy, technical standards, public perception and investor confidence. The project will demonstrate that the technology is on a cost reduction trajectory in line with the EU SET Plan targets and will be a stepping stone to larger commercial array scale up and further industrialisation. The action will integrate sub components such as moorings and PTOs - improving efficiency, reliability, scalability, sustainability and circularity of the technology. The combined actions of the work programme are expected to reduce the LCOE for the technology from €361/MWh to €245/MWh, a 32% reduction. For a 20MW array the LCOE would reduce from €185/MWh to €127/MWh.The project has 3 clear phases, phase 1 the initial design phase leading into a Go/No Go, phase 2 Demonstration in which it is expected that the baseline device will generate in excess of 1,650 MWh over the deployment and Phase 3 Commercialisation and Dissemination which sees the capitalisation and exploitation of the results. Ocean Energy and other consortium companies will actively exploit the results through new innovations, products and services. The results will be disseminated to feed both environmental databases and IEC electrotechnical standards. This action will take wave energy beyond the state of the art, building on the partners experience in prior EU projects enabling arrays of reliable de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of advanced optical tools for studying cellular mechanics at high spatial and temporal resolution' (Brillouin4Life) under Horizon 2020.

assistant: **Objectives**

A long-standing aim in the life sciences is to understand development and morphogenesis, i.e. how organismal shape is encoded by the genome and how cellular mechanics are involved in its execution. Lately, investigations have started to focus on the mechanical properties of the involved multicellular compartments, and the interwoven mechanical - molecular interactions at the cellular scale. While molecular components can routinely be visualized with fluorescence microscopy, assessing the mechanical properties of living cells with similar spatio-temporal resolution in a non-invasive fashion has long been an open challenge.Recently, a new type of optical elastography, namely Brillouin microscopy (BM), has emerged as a non-destructive, label- and contact-free technique which can probe visco-elastic properties of materials with diffraction-limited resolution in 3D. Yet, despite ongoing improvements, virtually all current implementations suffer from very low speed, high phototoxicity, and difficulties in quantification, thus prohibiting meaningful investigations in the life sciences.In this interdisciplinary proposal, my group will develop unique and innovative optical imaging technologies based on BM to overcome its current drawbacks and to establish it as a revolutionary tool for live tissue and cellular biophysics studies. In particular, we will work towards a highly-multiplexed BM with selective-plane illumination to maximize speed, resolution and depth penetration, while minimizing photodamage (Aim 1). At the same time, we will combine BM with other imaging modalities that will allow us to obtain correlative datasets and to accurately quantify the measured mechanical properties (Aim 2). We will then apply these methodological advancements together with fellow biologists