RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New methods, tools and systems to allow high performance maintenance of complex systems in the concrete' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Companies involved in the concrete industry face many problems with complex production units. This units are complex to manage because of their wide range of activity, the diversity of technologies, the equipments chaining with belt conveyors and other handling devices. This heavy equipments are subject to frequent breakdowns, very difficult to manage in a production environment and not easy to clean at the end of a production cycle. This situation is caused by the environment of the equipments that is not flexible and accurate enough to allow a real time control of the production unit. To maintain complex production units in the concrete industry, it is necessary to be equipped with adaptive control systems, and with tools and methods defined to optimise units cleaning:  adaptive control systems to optimise running and performances of complex and multipurpose units  tools and methods to optimise unit cleaning in order to reduce time (from 1h30 to 2h cleaning duration per 8 hours today to half an hour with the new system) and to increase efficiency. The objective of this project is to create a specific tool for maintenance of complex units in the concrete industry that allow to manage the units in a flexible way by the use of computer and sensors. This project is very important for SMEs in Europe and at least 1000 SMEs in the concrete industry could be interested in the results of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Biology and clinical staging of trypanosome neuroinvasion in sleeping sickness' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The project, based on a joint effort of five African and three European partners, foresees a highly integrated investigation of sleeping sickness or human African trypanosomiasis (HAT). This is a neglected but re-emerging disease in sub-Saharan Africa. HAT develops into an early haemolymphatic and a subsequent encephalitic stage, during which the causative parasite Trypanosoma brucei and/or increased numbers of lymphocytes are found in the cerebrospinal fluid. Arsenic compounds are still the drugs of choice for treatment of the encephalitic stage, but they are associated with severe and often fatal side effects. Relapses after current treatments also pose a serious problem.There are important gaps in knowledge concerning:(i) mechanisms by which trypanosomes invade the brain,(ii) when, post-infection, such invasion occurs, and(iii) effects of drugs on trypanosomes that have invaded the brain parenchyma.To discover mechanisms of parasite neuro-invasion and thereby devising candidates of diagnostic markers for an effective staging and new therapeutic management of HAT, the project plans to:1. Unravel the mechanism/s by which African trypanosomes cross the BBB and invade the brain;2. Identify candidate biomarkers for this event for diagnostic tools for therapeutic decisions and cure assessment;3. Investigate the therapeutic potential of new low-toxicity drugs, already in use for other diseases, which can interfere with trypanosomes that are invading or have invaded the brain;4. Determine clinical, immunological and neuro-physiological parameters that correlate to trypanosome neuro-invasion, as well as therapeutic windows for drugs to clear trypanosomes from the brain;5. Strengthen the research capacity of African investigators by providing transfer of technology and trainin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stability in algebraic geometry and its relationship with canonical Kahler metrics' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposal centers around the conjectural equivalence between the existence of special Kahler metrics and stability notions for projective manifolds coming from Geometric Invariant Theory. The stability condition is called K-stability, and the metrics in question are the extremal metrics, which includes the class of Kahler-Einstein metrics and the constant scalar curvature Kahler metrics. The projects will build on what is already known in this area and extend it to apply beyond projective manifolds, as well as connect with other parts of algebraic geometry, notably and stability notions for vector bundles and for pairs in birational geometry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fault Tolerant Aileron Actuation System for Regional Aircraft' (TAIRA) targeting Horizon 2020.

assistant: **Abstract**

The project TAIRA (Fault Tolerant Aileron Actuation System for Regional Aircraft) will deliver a highly innovative, cost-efficient, fault-tolerant, easy to maintain, safe and lightweight Electro-Mechanical Actuation system for the ailerons of regional aircraft, in full compliance to the Call requirements. In fact the project will offer the Topic Manager the chance to influence the selection out of two design strategies, with one of them offering an unprecedented level of robustness. Both solutions will combine Honeywell’s 60 years of EMA design and manufacturing know-how with its extensive expertise in Prognostics and Health Monitoring systems and Flight Control systems design and integration. This will guarantee not only a credible path to TRL5, but also an inherent certainty of product robustness, high aircraft dispatch availability, low maintenance costs, and minimum life cycle costs. Together with well-considered material choices, we are sure to offer a technology that is not only good for business but also for the environment (considering spare parts stocks, scrap value and high recycle-ability). The eventual TAIRA EMA will be manufactured in the Czech Republic and the UK, and will allow achieving up to 4% specific fuel consumption reduction on the aircraft level, thanks to the effective implementation of the More Electric Aircraft concepts. Considering the high levels of robustness, the jam-tolerant and environment-friendly design, exceptional component reliability (80.000 flight hours) and the low production cost, we are sure that this project will help driving the competitiveness of the European industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Integrating AI in Stroke Neurorehabilitation' (AISN).

assistant: **Concept**

Health services are increasingly moving towards a treatment continuum aligned with the patient journey. This transition will critically depend on the successful deployment of trustworthy AI-enhanced technologies that are accurate, secure, and trusted. The AISN project will develop and validate operating procedures and guidelines for integrating AI in a healthcare continuum, focussing on post-stroke rehabilitation. AISN delivers a representative AI health platform built from integrating validated platforms for data acquisition and access, clinical interpretation, whole-brain simulation, clinically validated intervention delivery and optimization and model-based prediction. The AISN integrated platform will be validated in the clinical context of rehabilitation in the outpatient and at-home phase and facilitate a concrete assessment of the fundamental ways in which AI-enhanced clinical decision-support will change the care pathway and the formulation of novel AI compatible treatment guidelines. AISN ensures an ethical approach by developing legal and ethical guidelines for the robust, fair, and trustworthy deployment of AI in health and validating acceptance and transparency of its solutions.  Building on the AISN platform, the project will test current standard operating procedures for integrating AI in health care and formulate and validate new ones where needed. The AISN guidelines and procedures will emphasize the evidence base and safety of clinical interventions, transparency, prognostics at varying time-scales, personalization of interventions, access to disease-specific information by clinicians, patients and their carers, and assure that the potential of AI is fully developed in the service of value-based medicine satisfying standards of security and safety. We w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ROll To Roll production of Organic Tandem cells' (ROTROT).

assistant: **Concept**

ROTROT (ROll to Roll production of Organic Tandem cells) project addresses Flexible, Organic and Large Area Electronic and photonics". OLAE potentially offers a giant step for consumer electronics and will continue to address mass market applications. In this OLAE field, Organic Photovoltaic (OPV) has to compete with Si and Thin Film PV. OPV has followed this tremendous growth and makes important additions to the motivation: low cost and easy manufacturing on flexible substrates by printing technologies. The problem of harvesting energy from light naturally presents a large area challenge and no manufacturing technique is faster than printing and coating under ambient conditions in terms of manufactured surface per unit time. This is in reality what gives OPV the competitive advantage over all other PV technologies.Power conversion efficiency of OPV cells has relatively been growing +0.5% per year from 1990. This enhancement is mainly due to new performing material discovery. If we want to reach relative growth up to 1 to 2% per year, we still have to work on new high absorbing polymers but also put great effort on device architecture design like the tandem structure. Novel disruptive concepts are required involving cheaper production of multilayered printed cells based on innovative engineered architectures (R2R printed tandem cell), new high performance materials (low band gap Eg ~1.5 eV, electrodes, high performance interface, barrier adhesive). Such innovative solutions are necessary for the technology to reach further than today's niche markets and to overcome the limitations by improving at least two times the currently achieved efficiency (12%), improving the lifetime by more than factor 4 from today's known OPV cell and reducing the cost (down to 0.7€/Wp). ROTRO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Zinc finger gene therapy in the brain for treating Huntington's disease'.

assistant: **Objectives**

Huntington’s disease (HD) is a lethal inherited neurodegenerative disorder which currently has no cure. Patients develop a devastating loss of muscle control and brain function, with symptoms typically developing at 35 - 45 years of age, although they can start much earlier. Suffering is high for both patients and carers, with death generally occurring within 10 - 15 years of diagnosis. We are working on a novel, curative gene therapy approach based on reducing the levels of the HTT disease gene products, while maintaining the levels of the normal protein. It is based on the delivery of proprietary zinc finger proteins (ZFPs) to the brain. Efficient delivery is accomplished through the use of viral vectors that carry the sequences coding for our ZFPs. Such ZFPs are artificially engineered proteins that specifically bind the defective expanded HTT DNA sequences (but not the normal HTT sequences or other, unrelated sequences). Binding represses the synthesis of the toxic gene products. We have published data demonstrating efficient mutant HTT repression in mouse (Garriga-Canut, M., et al. & Isalan M. Synthetic zinc finger repressors reduce mutant Huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci USA 109: E3136-E3145, 2012). We now need to improve the viral vectors for the long term expression of our ZFPs in the mouse brain, as the basis for a single-intervention, long-term therapy in humans (technical improvements). In parallel, we need to maintain the patent applications that protect the technology through various national and regional phases, and protect new developments that may arise (intellectual property), while engaging the necessary IPR and market studies/activities that help us find an industry partner that licenses our technology and moves it f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Inflammation and AD: modulating microglia function focussing on TREM2 and CD33 - Sofia ref.: 115976', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Alzheimer’s disease (AD) is an age-related chronic neurodegenerative disease with four main pathological changes in the brain: amyloid plaques, fibrillary tau tangles, inflammation and neuronal loss. Phagocytes around amyloid plaques in late onset AD (LOAD) may be neurotoxic but have limited motility and phagocytic activity, suggesting a dysfunctional activation. These phagocytes express the innate immune receptor TREM2 and CD33. Variants of both genes have been linked to LOAD. The main objectives of PHAGO are to find means of modulating microglia/macrophage activation via TREM2, CD33 and related signalling pathways, and determine the effects of such modulation on microglia/macrophage function, amyloid-β and neurodegeneration, in order to find a treatment for AD. PHAGO will deliver well characterized tools and knowledge through which to manipulate AD risk and provide targets and markers ready to progress to drug development. PHAGO will realise this goal by comprehensively attacking the problem simultaneously at multiple levels, including the molecular structures of the receptors, receptor ligand interactions, ectodomain function in vitro and in vivo, characterisation of receptor processing, modification and signalling, receptor-regulated signalling pathways, gene expression and phagocyte function in cells and animals, comprehensive analysis of receptor knock-in and knock-out models crossed to two different animal models of AD, and identification of receptor-related biomarkers in AD patients. Innovative approaches of PHAGO will include identification of new AD-risk genes using a TREM2 co-expression network approach, brain imaging of AD patients with TREM2 and CD33 variants, and generation of patient iPSC-derived microglia/macrophages to comprehensively phenotype gene var
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel electrochemical strategies for rapid, on-site multiscreening of illicit drugs'.

assistant: **Innovation**

Drug use continues to be a problem of major concern for public authorities worldwide. According to the World Drug Report elaborated by the United Nations Office of Drugs and Crime (UNODC) approximately 207,000 drug-related deaths occur per year. With between 162 million and 324 million people aged 15-64 having used an illicit drug — mainly substances belonging to canabinoids, opioids, cocaine or amphetamine-type stimulants group — at least once in the previous year, drug abuse continues to have devastating consequences on human health. The methods currently used to identify illicit drugs, such as colour tests, lack selectivity, and need further confirmation by expensive and time consuming chromatography-mass spectrometry methods, thus it is imperative to develop new sensing technologies that allow a fast, sensitive and selective detection of illicit drugs. This project proposes to develop novel, inexpensive and portable multisensing devices adapted for the rapid on-site screening of a number of illicit drugs, using recent advances in biomimetic materials coupled with electrochemistry. The multisensing devices will facilitate (1) detection and capturing illicit drugs crossing borders and (2) identification of drug users (e.g. drivers of vehicles at roadside, employees at work places, prisoners). In addition to rapidity and high selectivity of the detection, the sensing strategies will also give informations about (1) the type of drug and cutting agents (2) amount of drug present in biological samples. Moreover, the strategies employed will bring insights for better understanding of biomimicking nanoplatforms leading to more efficient technologies in health and biotech. The achievement of the actions goal will lead to reducing the incidence and prevalence of illicit drugs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Phonon Magnetic Moments and Angular Momentum in Flexible Framework Materials' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project will study how the magnetic moments and orbital angular momenta of phonons are related to chemical structure, electronic structure, and to each other. Phonons, which are particle-like vibrational excitations in solids, are not normally considered to have an angular momentum (a mechanical spin) or a magnetic moment (an electromagnetic spin). However, it has recently been discovered that vibrations that cause atoms to move in circles can in fact have these properties, although their magnitudes are thought to be extremely small in conventional materials. We aim to study these exotic properties of phonons in flexible framework materials, which are materials which combine extreme stiffness in some directions with extreme compliance in others. This combination can give rise to very low energy vibrational modes, which results in very large motions of the atoms, and therefore we expect flexible frameworks to have much larger phonon magnetic moments and angular momenta than in conventional materials. Our goal is to discover materials with very large phono-magnetic effects, ideally sufficiently large that they can be measured using existing experimental techniques. Large phono-magnetic effects would also allow the magnetic moment of the phonon to interact with magnetism due to the spins of electrons, leading to a heretofore undescribed physical interaction which could be useful in the study of magnetic materials. We will use computational and theoretical methods to study both materials where the circular motions of atoms require external stimulus to occur, and also chiral materials where the atoms can naturally move in circles. In this latter case, the introduction of magnetic order in the material can break the symmetry between phonons of one handedness and the othe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Assessing factors that affect farmers' willingness and ability to co-operate with biodiversity policies'.

assistant: **Concept**

Considerations concerning the protection and sustainable management of biodiversity are becoming more important in European agricultural practice. On the ground farming practice has to change, and this requires the co-operation of farmers. Experience in many European countries shows that the willingness of farmers to co-operate can vary greatly from case to case, and cannot be taken for granted. BIO fact will compile and analyse available knowledge about factors influencing farmers' decision making concerning cooperation with biodiversity and conservation policy, and will translate this knowledge into policy relevant tools and instruments. BIO fact will also make inventory of gaps in knowledge, identify priority research needs and stimulate cooperation among researchers, and between researchers and policy makers.