RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Post-translational modifications during floral initiation: molecular dissection of the UFO-dependent LFY activation'.

assistant: **Objectives**

Flowering plants are the most successful plant group on Earth and provide the basis for most human and animal food. The development of flowers is dependent on a gene regulatory network orchestrated by LEAFY (LFY), the master transcription factor. In Arabidopsis as in other flowering plants, LFY activity is dependent upon its interaction with UFO, a member of the Skp1–Cullin–F-box E3 ubiquitin ligase complex. The goal of this project is to understand why LFY requires interacting with UFO to build flowers. For this, we will apply state-of-the-art technologies including mass-spectrometry, crystallography, biochemistry and plant developmental genetics to identify and characterize the function of Post-Translational Modifications (PTM) on LFY or LFY interacting proteins, with special emphasis on ubiquitination. After identifying key residues involved in the LFY-UFO interaction or targeted by PTM, their functional importance will be assayed in planta. This project should facilitate better understanding of the mechanism of LFY activation. LEAFY and the development of flower will be used here as a model to understand the “activation by degradation” mechanism, still elusive in most organisms and poorly studied in plants. Moreover, understanding the principles governing LFY activation should provide means to modify at will the architecture of plant inflorescences. This project builds on the current background of the applicant in the field of Mass-Spectrometry combined with the outstanding expertise at Grenoble and high-throughput facilities in Structural biology and plant developmental genetics. Notably, the applicant will work within one of the top French Research Centers and in a multidisciplinary environment that will allow the fellow to acquire complementary ‘new knowledge and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Numerical modelling of inflatable airborne wind energy systems' (NUMIWING).

assistant: **Concept**

The proposed research aims to numerically model the mutual interactions between the aero- and structural- dynamics of inflatable airborne wind energy systems. Such systems offer several advantages over conventional wind turbines. For example, they harness stronger and steadier winds by flying at moderate to high altitudes, they are cheap to manufacture, and they can be rapidly deployed.Airborne wind energy (AWE) is a novel area of research, where conventional wind turbines cannot be used. At increasing altitudes, an excessive amount of structural materials would be needed to withstand the high mechanical stresses induced by heavy rotors, when placed on tower-based foundations. A competitive approach for AWE is to harness wind energy with an inflatable wing tethered to a ground station. Numerical tools capable of calculating the complete interactions between aerodynamics, structural dynamics, and flight dynamics of such power systems are currently at an early stage of development. An efficient strategy to minimise the computational cost is also lacking. To fill this knowledge gap, cutting-edge fluids and solids computational methods will be employed. Key components are: (a) a conservative dual-mesh approach for modelling fluid-structure interactions, (b) a method for predicting the motions of an inflatable membrane wing, and (c) dynamic mesh adaptivity to refine the fluid-structure interfaces.The overall deliverable is an open-source code to model the mutual interactions between airflows and airborne wind energy systems. The proposed numerical tool will be capable of: (a) determining the impact of the system on the surrounding airflow, (b) computing the interactions between aero- and structural- dynamics of an inflatable wing, and (c) estimating the power extracted by th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting intracellular signalling of melanoma invasion towards microRNA-based therapy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Melanoma, a melanocytic neoplasm, is a highly lethal and treatment-refractory cancer.  While progress has been made in deciphering the molecular underpinnings of melanoma, successful treatment for metastatic melanoma remains frustratingly uncommon. Complex phenotypes such as changes in cell morphology, motility, and invasiveness are rarely regulated by a single gene. Because a single microRNA (miR) may target thousands of genes, it is possible that altered expression of a single miR can regulate complex phenotypes. To identify miRs that regulate melanoma invasiveness, we performed a miR library screen for melanoma invasion potential. The melanoma-specific miR, miR-211, was the first highest hit which significantly decreased melanoma invasiveness. Our finding is the first description of an intronic miR that assumes a tumor suppressive function previously ascribed to its host gene (Levy et al Mol Cell 2010). In this study, we will further decipher miR-211 affect on melanoma invasion process by using an in-vivo model, we will compared our results with human clinical information to establish clinical relevance, we will identify new miRs that affect melanoma progression and we will dissect the cellular pathways regulated by these miRs and we will look for novel therapeutic approaches towards miR-based treatment of melanoma. Interestingly, both genes, miR-211 and its host gene are targets of MITF, the melanocyte lineage master regulator. We will therefore decipher the epigenetic changes that affect the transcriptional activity of MITF. We will globally study the cross talk between genome alteration and gene expression, while using MITF role in melanoma as a model in order to determine MITF dependent-epigenetic pattern.Our preliminary data suggest that modulating miR-211 drama
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Functional diversity of Biocrusts: towards ecosystem services quantification in drylands'.

assistant: **Concept**

Global change is simultaneously the cause and the consequence of a dramatic biodiversity loss on Earth, with the subsequent degradation of ecosystem services. Understanding the major drivers of ecosystem services delivery is critical to develop sound management and conservation strategies to assure their sustained provision. This is particularly urgent in drylands; one of the most abundant, populated and vulnerable ecosystems in the face of the global change. In this context, functional diversity has emerged as a key concept in ecological research, since it links the range, variety and abundance of functional traits (i.e., attributes of an organism or group of organisms that reflect biological functions) to their effects on ecosystem processes, and thus, on ecosystem services delivery. Previous research on functional diversity has been mostly focused on vascular plants, while the contribution of soil lichens, mosses, and cyanobacteria forming “Biocrusts” has been understudied. However, Biocrusts may be the dominant life form in drylands, where they perform critical functional roles. Our hypothesis is that if we know how Biocrusts affects ecosystem processes, and we are able to model their distribution and abundance, we will have a more precise measure of the ecosystem functions they perform. Consequently, we will be able to quantify their contribution to ecosystem services in drylands. This knowledge will complement and improve the scope of management, conservation and restoration strategies, traditionally focused on species diversity, rather than functional diversity, and regarding vascular plants exclusively. BCSES will be developed in a top research centre –Centre of Environmental Biology (CBA), Portugal- which embraces highly scientific expertise in the field, and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding long-term FLOOD pattern variability in Western Mediterranean using natural ARChives', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Society is becoming more vulnerable to natural climate variability through increasing exposure of people and infrastructure. Notably, floods are among the most destructive natural hazards causing widespread loss of life, damage to infrastructure and economic deprivation. Robust knowledge about their future trends is therefore crucial for the sustainable development of societies worldwide, particularly in sensitive areas such as Western Mediterranean. This Marie Sklodowska-Curie Action (MSCA) aims to provide a more comprehensive understanding of the long-term variability of hazardous (high-impact)  floods at different temporal and spatial scales. Through this action the Experienced Researcher (ER) will work within the Hydro-Meteorology, Climate and Society Interactions (HMCIS) group at the Host Institution (IGE) to develop a high-impact flood database in Western Mediterranean. State-of-the art statistical tools applied to the flood database will allow the ER i) to evaluate, for the first time, the causes of non-stationarity in the long-term flood pattern evolution at a sub-continental scale and; ii) to investigate the role of the climate variability on the high-impact flood patterns at centennial to millennial time-scales in W Mediterranean. The ER has expertise in high-resolution proxies of flood events contained in lacustrine and fluvial sediments. He aims to obtain specific training in geo-statistical tools applied to Flood Hydrology at the Host Organization. This MSCA project will significantly contribute to the career development of the researcher and will enhance our current understanding of the natural variability of floods and its trace in the sedimentary record. Therefore, this study will help to address major concerns in relation to flood hazards and adaptation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Copenhagen biosystematics centre' to be submitted under Fifth Framework.

assistant: **Abstract**

Description:The Copenhagen Biosystematics Centre (COBICE) at the University of Copenhagen comprises the Zoological, Geological and Botanical Museums, and the Evolutionary Biology, Zoo morphology and Botanical Molecular Systematic laboratories. The collections at COBICE comprise about 20 million specimens, including, e.g. 75,000 unique type specimens - Arctic, especially Greenland and Danish animals - deep-sea animals - whales - South American Quaternary mammal fossils - the World's largest databases on African terrestrial vertebrates - tissue collections for DNA analysis, esp. birds (3,000 species) and African mammals - fossils from Greenland - mo-clay Tertiary fossils - plants from Greenland, Denmark, Thailand and NE Africa. Equipment available at COBICE includes light, fluorescence, transmission electron and scanning electron microscopes, DNA sequencing facilities, X-ray apparatus, and image analysis system.Application:Applications can be submitted twice a year by e-mail, fax or mail. The application form and the procedure for applying are described on the COBICE Home Page http://www.zmuc.dk/commonweb/COBICE.htm.Project Manager:Henrik Enghoff, Zoological Museum, University of Copenhagen, Universiteitparken, 15, Copenhagen OE, 2100 Denmark,Tel: +45-35321036Fax: +45-35321010E-Mail: henghoff@zmuc.ku.dk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Discovering Gene-Drug Interactions in Breast Cancer With a Systematic and Genetically Tractable Model' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Biomedical research has been very successful in finding the individual genes that are deregulated in cancer and it is estimated that ~2% of all genes can be classified as “cancer genes”. However, it has proven challenging to translate this genomics knowledge into effective treatments.One complication is that cancer cells typically carry many molecular aberrations and every tumor displays a unique pattern. This heterogeneity complicates the application of drugs and biologicals as it often interferes with patient response. Thus, unraveling the complex interplay between cancer genes and drugs is of great importance for effective patient-stratified cancer therapy.Besides playing a role in drug resistance, the molecular changes also result in cancer cells becoming uniquely dependent on certain gene products or pathways. These cancer “vulnerabilities” offer opportunities targeted therapies, including those based on oncogene addiction and synthetic lethality. Therefore, these concepts have attracted much interest as they can help bridge the gap between cancer genomics and effective treatments.I propose to identify cancer vulnerabilities and drug resistance mechanisms in breast cancer by developing a genetically tractable model system. Designed to capture relevant constellations of genetic aberrations found in patients, it extends our recently developed, systematic screening platform. Combined with bioinformatics integration of cell line data, this will result in a unique and powerful approach.I aim to identify functional interactions between breast cancer genes and experimental or approved drugs. Detailed characterization of gene-drug interactions will reveal their translational potential for targeting specific cancer vulnerabilities in patients, or as biomarkers. Together, th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unravelling specificity of epi-metabolic regulation in mouse development' (ChroMeta).

assistant: **Concept**

When environment of the embryo changes or when development progresses metabolic reactions are rapidly affected. These alterations to chemical reactions are coupled to epigenetic memory. However, without mechanistic data on how this coupling occurs it is difficult to understand how normal embryogenesis can proceed. This project will elucidate how metabolic changes result in specific epigenetic outcomes and address the function of such regulation. As a model we will use mouse implantation, a process tightly linked to dramatic alterations to chromatin and transcription. We found that this is also associated with extensive metabolic rewiring and that disrupting metabolic flows results in both lineage-specific and mark-specific changes to chromatin. While multiple studies uncovered that metabolism fuels chromatin modifiers with co-factors, the fundamental biological question of how specificity is achieved remains unanswered. Here we will address this challenge by directly testing the three most likely hypotheses: 1) that metabolic reactions shuttle into the nucleus where they specifically fuel chromatin changes; 2) that chromatin-bound metabolic enzymes regulate gene expression and 3) that only specific chromatin modifiers are sensitive to metabolic changes. To address these questions, we will go beyond description as we supplement multi-omic approaches with mechanistic experiments both in vitro and in vivo. Firstly, will use perturbations of nuclear metabolic enzymes and their chromatin binding. Secondly, we will implement protein engineering to render chromatin modifiers resistant to the availability of their co-factors. By uncoupling epi-metabolic regulation, we seek not only to uncover its importance for controlling chromatin states but also the implantation developmenta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of New digital Microphone-MEMS-Sensors for wind tunnels with open/closed test sections and flight tests' (AEROMIC), addressing dissemination and exploitation.

assistant: **Impact**

AEROMIC aims at envisioning an innovative sensor technology for aeroacoustic measurements based on high performance MEMS microphones integrated as microphone arrays, and the development of a compact smart sensor surface through the integration of sensors and electronic components using vertical integration technology. The main objective of this proposal is the development of novel high performance digital wall-mounted microphone-MEMS-sensors for surface unsteady pressure and wall shear stress measurements for future noise reduced large passenger and other aircrafts. Novel miniaturized piezoelectric and piezoresistive MEMS microphones with properties exceeding the state-of-the-art in terms of bandwidth, sensitivity, dynamic range and robustness will be developed to capture the unsteady pressure fluctuations underneath the turbulent boundary layer with very high spatial and temporal resolutions in a very broad frequency range. The two MEMS microphones can be optimized for the wind-tunnel testing (WTT) and flight testing (FT) applications as required, respectively.


**Keywords:** piezoelectric MEMS microphone, piezoresistive MEMS microphone, aeroacoustic measurement, microphone array, wind-tunnel test, flight test, turbulent boundary layer, noise reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated systems for patient dependent treatment planning and execution in dental health care (ISY-DENT)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Dental Health Care affects nearly everyone from youth to old age. Practically 100 per cent of the population worldwide has to undergo a dental treatment from the different subjects in the course of their life. The application of Computer Aided Methods can improve the quality of treatment outcome, increase its effectiveness and enable a patient dependent treatment planning and analysis of the treatment strategy. At present only a few commercially available systems exist that support the dentist (CEREC system in conservative dentistry, Arch mate system in orthodox- tics). But these are isolated solutions that are not open for data transfer bet- wean the different disciplines or have interfaces to individualized biomechanical analysis tools. The ISY-DENT consortium intends to concentrate the research eve- forts in dental biomechanics in the EU, work out common solution platforms and de- fine principles of integrated treatment planning systems for Dental Health Care.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mental HEaLth Promotion in healthCARE workforce (HELP-CARE): A realist and economic evaluation of an inter-sectoral and multi-level intervention in Denmark.' (HELP-CARE) under Horizon Europe.

assistant: **Objectives**

Supporting the mental wellbeing (MWB) of healthcare workers (HCWs) is a global public health priority with far-reaching societal and economic consequences. HCWs face multiple occupational risks that can significantly affect their mental health. The COVID-19 pandemic has exacerbated strained working conditions in hospitals, leading to increased rates of stress, depression, and burnout, particularly among women and nurses. This has resulted in a concerning shortage of HCWs, triggering a negative cycle of deteriorating working conditions, reduced job satisfaction, compromised healthcare quality, and patient safety. To address this critical issue, an intersectoral action using innovative, multi-level interventions promoting MWB is necessary. However, the lack of robust evidence of cost-effectiveness for preventive approaches in the healthcare sector hampers informed health policies and sustainable actions. Three major hindrances to progress are identified: the absence of positive mental health indicators (MWB) as the primary intervention outcome, the need for a multifaceted approach considering individual and organizational factors, and the lack of health economic evaluations.The HELP-CARE project emerges as a solution, aiming to provide a realist and economic evaluation of a multi-level MWB-based intervention in the public healthcare sector launched by the technological company HOWDY.care in Denmark. The study will use Structural Equation Modeling (SEM) and Cost-Benefit Analysis on large longitudinal data of Danish HCWs to understand how this type of intervention works and its economic impact. HELP-CARE entails a strong inter-sectoral collaboration (academic-public-private-NGO) whose findings will pave the way for more effective interventions to enhance HCWs' MWB.The invol