RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'An Integrated Fruit Processing and Preservation System for SME Mate rial and Equipment Manufacturers'.

assistant: **Innovation**

The consumption patterns of fresh fruit over the past century have been dependent on the availability of methods to ensure that the product reaches the consumer in peak condition. The traditional method for delivery of fruit has been to harvest when under ripe and to try to control the ripening process during the transport phase. The fruit is then delivered and sold whole. However, the demand for fresh cut fruit, which is ready peeled, cored and segmented has soared in the past ten years, led by demand for convenient, natural, high added value foods from affluent consumers and a market aware catering industry. There are approximately 1100 SMEs in the EU who manufacture additive materials and equipment for fruit processing companies. In common with most other SME equipment manufacturers, within the sector, we currently produce equipment designed to take the target fruit whole, to perform a single operation such as skinning or juice extraction. However, we have identified a market opportunity for a novel, integrated processing and preservation system, with which fresh cut fruit may be prepared at the point of harvest, preserved and maintained in a high quality form for the long enough to transport it to the final processor and vendor. Since the production of fruit is both localized and highly seasonal, leading to the requirement for a substantial amount of storage and transportation, there is a tremendous amount of waste associated with the commercial transportation and processing of fruit. Over 280 million Tonnes per annum, of fruit is shipped around the Globe, with EU demand accounting for 28% of that total. Industry estimates are that nearly 40% of the volume of fruit purchased and delivered to processors, from the grower, is discarded for the following reasons: - Unwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design for Ship Safety in Extreme Seas' under Seventh Framework.

assistant: **Concept**

The strategic objective of EXTREME SEAS is to enable European shipping industry to improve the design of ship structures that are exposed to rough climate, by providing technology and methodology that need to be a part of design for ship safety in extreme seas. The project will relate and adapt to safety regulations including Classification Societies’ Rules. The design procedures provided will be formulated in terms of recipes supporting harmonized standards that give presumption of conformity to the safety requirements. The project results will help shipping industry to adapt to climate change. The project addresses assessment of extreme sea states, and ship behavior in such sea states. The project will study physical and statistical properties of extreme waves, and develop advanced numerical and physical simulation models for wave-structure interaction. A further objective is to develop warning criteria for marine structures against extreme sea states and extra-ordinarily large waves, and to implement them in a marine weather forecasting system operated by a meteorological office belonging to the Consortium. The developed warning criteria will be available for decision support systems for marine structures. The developed methodology and tools will be generally applicable to different ship types. The case studies considered in EXTREME SEAS will be devoted to container vessels, to passenger ships, to LNG carriers and to product and chemical tankers. Critical responses will be investigated including green water impact on superstructures of the passenger ships. Weaknesses of the current design procedures for ship structures will be highlighted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CITIZEN MEDIA' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Citizen-Media is a collaborative research project on audio-visual systems to enable multiple non-professional users to co-create networked applications based on their own user-generated content. In this project new ways are investigated on how to exploit the huge amount of user-generated content in innovative ways to support the people in their daily life and how technology will enable social change to strongly involve users for co-creating networked applications. This work will introduce new concepts that may modify the role of stakeholders in classical value chain for content delivery.To that aim applications, services, systems, infrastructure, technology and architectures are developed based on a user-centric approach. The goal is to enable any user at any location with any device to consume, author and publish his own content towards a networked audio visual system. Based on user-generated media recorded by different users at different times, an open and flexible architecture will be proposed that creates a novel networked application each time a user uploads new content. The underlying infrastructure hides the complexity of content handling for the end user by supporting trans-coding of formats, customisation and mixing of personal and private content. To facilitate co-creation requires that the audio visual system is able to handle a massive amount of user-generated content in different formats in real time, annotate and store this content into huge databases, search, retrieve, process and render all these pieces of user-generated content to create a new experience. Combined with new technology for collaborative communication and easy and multimodal user interfaces, this will lead to appealing new applications. End-to-end service delivery, network and operational
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Targeting of DNA deaminase AID via transcription and the RNA pol II elongation complex' (2007-2013) under Seventh Framework.

assistant: **Objectives**

In B cells, antibody repertoire is created via two DNA instability complexes, one of which uses DNA cytosine deamination and is needed for immunoglobulin (Ig) diversification. Targeting of DNA deamination is poorly understood and mis-targeting can lead to genetic pathologies. Activation induced deaminase (AID) catalyses the hydrolytic deamination of cytosine residues, with the resulting uracil inducing DNA instability leading to Ig diversification. Recently AID has been implicated in inducing developmental DNA demethylation and pluripotent stem cell formation. Although transcription had been implicated in these mechanism, no direct evidence existed linking AID activity and transcription.The aim of this application is the analysis of AID containing transcription complexes and the role of RNA pol II modification during Ig diversification and epigenetics. Proteomic analysis of AID containing complexes from cytoplasm, nucleoplasm and chromatin revealed distinct associations, with the chromatin complex containing subunits of the elongating RNA pol II, transcription elongation and chromatin remodelling complexes. Biochemical analysis in vitro and in cell lines will identify direct interactions and domains and subsequent in vivo reconstitution of AID mutants determining in vivo relevance. Genetic analysis of candidates using transgene and knockout in cells and mice will delineate the molecular pathways of how transcription can alter the targeting or efficiency of AID. To further determine the role of the candidates on the loci, various forms of ChIP analysis will be utilised (e.g. double ChIP & ChIP-Seq); including the effect of RNA pol II modification, chromatin markers, and associated factors.Conclusions of this study will provide novel and detailed insight into the molecula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering the mechanistic basis of minimal residual disease and treatment resistance in acute myeloid leukemia' (MRDAML).

assistant: **Concept**

Acute myeloid leukemia (AML) is one of the most aggressive and deadliest cancers with frequent relapse. Although initial therapies eliminate most AML blast cells, rare cells with leukemic stem cell (LSC) activity can persist and likely generate minimal residual disease (MRD) to re-initiate AML. Thus, targeting resistant LSCs during MRD might provide a unique opportunity to prolong remission and prevent relapse. However, because it is notoriously challenging to identify rare LSCs present within the vast number of normal blood cells during MRD, the phenotype, plasticity, function and mechanisms of LSCs in resistance and relapse remains poorly understood.Previous study from the Trumpp laboratory demonstrated a convergent pathway via hypermethylationn to drive initiation and progression of AML with IDH mutations or BCAT1 overexpression. However, the common and distinct mechanisms driving resistance in the two AML subtypes has not been explored, despite the observation that BCAT1 expression is upregulated in LSCs and upon relapse.Thus, in this proposal, I will first perform systematic phenotypic characterization of IDHmut/BCAT1hi AML cells to develop a high-quality LSC enrichment strategy. Subsequently, I will combine cutting edge single-cell multi-omics technologies to deeply characterize the mutational, transcriptomic and epigenetic dynamics of individual LSCs at diagnosis, MRD-positive remission and relapse. State of the art analytical methods will be used to integrate these data to dissect IDHmut/BCAT1hi AML with unprecedented resolution, examine the contribution of LSCs in MRD, and identify molecular regulators mediating LSC survival and resistance. Functional validation using pharmacological intervention, genomic editing in cell lines and patient-derived xenograft mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Character Matters: Individual Character, Moral and Political Education in Victorian Britain' in the context of a Horizon Europe call.

assistant: **Objectives**

This project (CHARMA) is a study of the political importance of the concept of personal character in Victorian England. CHARMA will be developed through a 24-month European Fellowship with the University of Manchester. The overarching goal of this project is understanding the relationship between the cultivation of individual character and the plans for building a peaceful society, at a time when Britain was experiencing rapid socio-economic and political change. To achieve this overarching goal, I divided my project into two sub-goals. My first sub-goal is understanding the Victorian discourse of character and its political importance through texts of early and mid-Victorian political thought. This study will be pursued by textual analysis. My second sub-goal is demonstrating that this concept influenced actual plans for educational and social reform. To do so, I will focus on a case-study: I will analyse the reform practices and institutions of a highly influential group of Dissenters, the Unitarians, in Victorian Manchester. This study will be pursued through archival research, using the vast collections in the University of Manchester Archive. I will also used social network analysis to trace the connections of Unitarians with different social groups and represent them graphically. This project will contribute to the fields of intellectual history, history of political thought and political philosophy. CHARMA's methodology is interdisciplinary, as it combines different fields, different kind of sources and a practice-based, bottom-up approach with a contextualist study of published texts. CHARMA also uses a mixed-methods approach and provides methodological innovation by introducing a new method, social network analysis, into the field of intellectual history.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spectra of Molecules in Strong Magnetic Fields' (MAGSPEC) targeting Horizon 2020.

assistant: **Abstract**

Electronic spectroscopy is one among several types of spectroscopy employed to study molecules in stellar objects. Strong magnetic fields, as in white-dwarfs and neutron stars, can severely distort these spectra. To accurately interpret the data, we must understand the forces shaping the spectra in situations so far removed from terrestrial conditions. Such strong fields also imply a breakdown of the perturbative mechanism commonly used for studying magnetic phenomena in the pertinent regimes on earth. We shall focus on the intermediate regime of field strengths (~10^5 T), where, neither the magnetic field nor the inter-particle interaction can be treated as a perturbation leading to novel physics and chemistry, that remains little explored for molecules. This project seeks to develop the methodology to compute excitation energies and potential energy surfaces in the presence of strong uniform and non-uniform magnetic fields, included non-perturbatively, at varying levels of theoretical complexity (Hartree-Fock, Density Functional Theory, Random Phase Approximation, SRCC and MRCC) and study the distortion of these spectra across a range of magnetic field strengths. We shall focus on analysing the source of these distortions at the microscopic level, ie. which of orbital effects, spin effects, correlation effects  and relativistic effects play the determining role. This project is multidisciplinary using principles of quantum chemistry in tackling astrochemical problems. The study is fundamental and is expected to reveal interesting results relevant even for the weaker fields on earth. The benchmarking of the standard DFT exchange-correlation functionals against CC in the regime of strong magnetic fields will have a long-term impact as most existing DFT approximations ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Demonstration of a self-erection system for wind turbine towers'.

assistant: **Innovation**

One of the main wind market trends is to increase the size of wind turbines in order to take full advantage of available wind resources and thus improve the COE. However, such increase has led to a number of limitations, both technical and economic, in the installation of towers over 120 m, which result in a bottleneck that paralyses this market trend.Large cranes are used for the installation of all types of towers, which result in significant cost overrun in the installation of towers higher than 120 m and limiting the installation of towers higher than 140 m, thus, paralyzing the development of the sector.In this area, NABRAWIND has developed an effective, reliable and with a competitive cost system that enables assembling any type of wind turbine tower, nacelle included, without any limitation in height and with complete independence from auxiliary cranes, thanks to a new lifting concept system based on hydraulic lifting mechanism which allows the system to operate from the ground.The overall objective of this project is the demonstration to ""stakeholders"" of the functionality and reliability of the final configuration of the new self-erection system for the construction of wind towers in a real operational environment with the aim to confirm that the design specifications and requirements of the application are fulfilled.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'It takes a village: an interdisciplinary community neuroscience approach to characterize multigenerational interactions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

While many of our daily interactions involve people of different ages, little is known about how the human brain supports naturalistic communication between generations. InterCom combines laboratory research with real-world experimentation, and intrapersonal analyses with interpersonal measures (e.g. ‘brain-to-brain synchrony’), to better understand multi-generational communication, both within and beyond family contexts. Do age-related differences in brain rhythms inhibit conversational flow? How do listeners process speech produced by children or older adults? Can intergenerational miscommunications be partly attributed to the fact that children and older adults are less likely to predict what others are about to say? How can we overcome implicit neurobehavioral culprits of misalignment? Curiously, while laboratory studies have shown that there are significant differences in how children, adults, and older adults process (non)verbal information, these and related questions remain largely unanswered.  InterCom will test a novel ‘community neuroscience’ approach, one that flows from the real world, to the lab, and back. We will collect brain, body, and language data from socio-culturally diverse groups of children, adults, and older adults during real-world storytelling events that are co-designed with community partners. The data collected during these events will then inform and constrain subsequent laboratory studies and vice versa. As such, InterCom leverages the benefits while offsetting the downsides of both naturalistic observations and experimental control, and will innovate on and combine laboratory and real-world data collection, stimulus development, and data analysis in a truly reciprocal manner.Together, InterCom will tread previously uncharted territory in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Co-creating Ecosystem-based Fisheries Management Solutions' (MAREFRAME).

assistant: **Concept**

MareFrame seeks to remove barriers preventing a more widespread use of an Ecosystem-based Approach to Fisheries Management (EAFM). It will develop assessment methods and a Decision Support Framework (DSF) for management of marine resources and thereby enhance the capacity to provide integrated assessment, advice and decision support for an EAFM. Enabling comparisons between relevant ""what-if"" scenarios and their likely consequences, DSF will support the implementation of the new Common Fisheries Policy (CFP) and the Marine Strategy Framework Directive (MSFD). The project SMEs, together with RTD institutions and stakeholders, will develop and demonstrate the use of innovative decision support tools through training actions, role-play and workshops. Indicators of Good Environmental Status (GES) will be developed along with models for ecosystem-based management. The models will take multi-species approaches into account and be developed and compared through seven datasets of six European regional seas. The models will draw on historical data sets and data from new analytical methods. Model performance will be compared and evaluated using a simulated ecosystem as an operating model. Learning from the experience of previous and on-going research, MareFrame integrates stakeholders at its core using a co-creation approach that combines analytical and participatory processes to provide knowledge that can be applied to policy-making, improving management plans and implementation of EAFM. The project dissemination will use innovative ways to ensure effective usage of project outcomes. The work packages and the allocation of roles have been designed to ensure effective collaboration through the project’s lifetime. MareFrame liaises with other national and international research