RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Industrial implementation of processes to render RCS safer in manufacturing processes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In 1997, the International Agency for Research on Cancer (IARC) classified Respirable Crystalline Silica (RCS) in the form of quartz or crystobalite from occupational sources as carcinogenic for humans (category 1). Crystalline silica is an essential raw material for the production of virtually all the goods of everyday life. As a consequence, there can be significant amounts of RCS in the environments of many manufacture processes. Hence, a vast number of European workers are potentially exposed to RCS at their workplace. The ceramics industry is particularly concerned, since its products (heavy clay products, floor and wall tiles, sanitary ware, tableware, etc.) are based on silicates. The relevant bodies used in the manufacture of these products include considerable amounts of quartz, which is indispensable for the manufacturing process.The formal adoption of the IARC evaluation in Europe will strongly affect the way the products containing crystalline silica are produced, labelled, packed, marketed and disposed. These measures will clearly entail significant costs and influence the competitiveness of the companies, especially of the SMEs. However, there are evidences that the toxicity of the quartz can be practically nullified by certain substances. The mechanism by which these substances act seem to be related with the saturation of the silanol groups in the surface of the RCS particles, by “coating” them. Although some of the above treatments were known for years, they are not industrially used up to date. The main objective of the present project is the industrial implementation of these treatments in the ceramic manufacturing processes, thus transforming the quartz-containing raw materials into intrinsically safe products. The characteristics of the ceramic comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polymer-virus hybrid vectors for safe and efficient gene therapy of prostate cancer' in the context of a Fifth Framework call.

assistant: **Objectives**

Efficient and safe vectors for gene therapy of prostate and bladder cancer will be developed by modification of viruses with multivalent hydrophilic polymers. This approach is particularly powerful because it permits complete shielding of viral tropism without genetic engineering. The resulting vectors are less immunogenicthan normal viruses and will be targeted to tumour cell-surface receptors. Their infectivity of these vectors is not affected by neutralising antibodies in serum, a major limitation of current use of viruses for gene delivery - particularly in the clinics. Viruses retargeted in this way operate at a lower MOI than regular viruses in serum and maintain extremely high efficiency of gene expression. These vectors should provide an effective means to realise the substantial promise of gene therapy, and this proposal combines cell/molecular biology and virology with polymer chemistry in their development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Lightweight switchable smart solutions for energy saving large windows and glass façades' to be submitted under Horizon 2020.

assistant: **Abstract**

Between 25 and > 60% of total energy transfer through building envelopes is driven by glass based components such as windows, glass facades and glass roofs. In winter, heating energy demand of buildings with high windows-to-wall ratio (WWR) in north- and east direction is up to 35% higher compared to buildings with only small windows. In summer, large windows and glass facades result in high heating of the building interior: cooling energy demand is increased by a factor ≈ 1.5 to 5 when WWR increases from 10% to 90%. Non-residential buildings often make use of large windows or glass facades for building-functional and representative reasons and therefore hardly suffer from increased energy demand. Switch2save targets active management of radiation energy transfer through glass-based building envelopes by integrating transparent energy smart materials with switchable total energy transmission values (g-value). Such materials are electro-chromic (EC) or thermo-chromic (TC) systems. Intelligent switching of those allows significant reduction of both heating energy demand in winter and cooling energy demand in summer. Switch2save’s unique and lightweight combined EC and TC smart insulating glass unit will be a breakthrough in performance (plus 20%); low-cost potential (minus 33% manufacturing cost) and increased design opportunities compared to state-of-the-art smart shading solutions. Switch2save prototypes will be demonstrated in two representative buildings – a hospital in Athens, Greece and an office building in Uppsala, Sweden by replacing > 50 windows and 200 m² glass façade area. Continuous monitoring of energy demand at thermal comfort levels inside the buildings for at least one year before and after TC/EC integration will verify energy saving potential of Switch2s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Does inter-tissue mechanical coupling coordinate neural tube closure?'.

assistant: **Concept**

Failure of neural tube closure causes neural tube defects (NTDs), which continue to affect 1:1,000 births in Europe. Successful closure requires poorly understood coordination of cellular force-generating mechanisms in different embryonic tissues. By adopting a novel bio-engineering approach, I aim to generate the first spatiotemporal map of mechanical forces in neural tube closure. This unified biomechanical understanding of morphogenesis will provide a step-change in our interpretation of genetic/teratogenic insults underlying NTDs.In this project, I will identify the physical forces mediating neural tube closure and describe their inter-tissue coordination during development. This will be based on intravital 3D (i3D) bioprinting, a novel method established by the Elvassore group at UniPd (host). This method allows 3D printing of biocompatible force sensors directly inside the neural tube of living chick embryos, a well-established vertebrate model. Combined with cutting edge chemical engineering and computational modelling, I will investigate the spatiotemporal coordination of mechanical forces and assess whether connected epithelial tissues are mechanically coupled. The high positional accuracy of i3D enables previously unfeasible perturbations of morphogenesis to test mechanical coupling between connected epithelia. These physical interventions will be paralleled by microfluidic regional delivery of pharmacological inhibitors to biochemically perturb the same morphogenetic processes. Together these studies will pave the way for the identification of novel preventative and therapeutic strategies to enhance cellular force-generating mechanisms during neural tube closure.


**Keywords:** Biomechanics, Finite element modelling, Neural tube
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Model theory and its applications: dependent classes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Model theory deals with general classes of structures (called models).Specific examples of such classes are: the class of rings or the class ofalgebraically closed fields.It turns out that counting the so-called complete types over models in theclass has an important role in the development of model theory in general andstability theory in particular.Stable classes are those with relatively few complete types (over structuresfrom the class); understanding stable classes has been central in model theoryand its applications.Recently, I have proved a new dichotomy among the unstable classes:Instead of counting all the complete types, they are counted up to conjugacy.Classes which have few types up to conjugacy are proved to be so-called``dependent'' classes (which have also been called NIP classes).I  have developed (under reasonable restrictions) a ``recounting theorem'',parallel to the basic theorems of stability theory.I have started to develop some of the basic properties of this new approach.The goal of the current project is to develop systematically the theory ofdependent classes. The above mentioned results give strong indication that thisnew theory can be eventually as useful as the (by now the classical) stabilitytheory. In particular, it covers many well known classes which stability theorycannot treat.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural Maintenance of Ageing Aircraft' (1994-1998).

assistant: **Innovation**

BE95-1053 Structural Maintenance of Ageing Aircraft - SMAAC Aircraft manufacturers as well as airlines and maintenance suppliers are facing the fact that the age of the fleets in the civil transport aircraft business are increasing dramatically. This is also true for airplanes manufactured in Europe. In order to maintain the high safety standard of today's aircraft during higher service life times, considerable inspection and repair actions have to be accomplished. There are different typical" ageing aircraft phenomena, particularly multiple site damage (MSD) and multiple element damage (MED), which are not covered by the standard fatigue and damage tolerance approach. Other phenomena like corrosion may even add to or enforce these problems. The durability of aircraft structures containing MSD and/or MED will be reduced unless corrective actions are taken at an early stage. In extreme cases, such as occurred in the "Aloha" incident, the structural integrity of the aircraft could be compromised by the presence of MSD and MED. In order to provide reliable time of inspection and of embodiment of preventive repairs for existing aircraft as well as better long term durability for future aircraft, the following main research tasks are conducted: - Theoretical and experimental investigations to derive engineering models for the assessment of the initiation of MSD, growth of MSD and residual strength of structures in the presence of MSD or MED. - Usage of both in-service and experimental/theoretical examinations for the assessment of deteriorating effects, which may increase the ageing aircraft effects in certain areas of the fuselage or wing structures. The methods developed above may also be used for the assessment of the fatigue and damage tolerance behaviour of old repairs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Submarine Landslides Impact on Coastal and Offshore Environments: Modelling and Forecasting' in the context of a Horizon Europe call.

assistant: **Objectives**

The influence of human activities on the marine geological environment has reached an unprecedented magnitude throughout history.  The decomposition of hydrates within reservoirs due to changes in temperature and pressure conditions can result in the release of overpressured fluids, potentially triggering submarine slope failures that pose significant risks to offshore engineering developments and marine ecosystems.  Nonetheless, the existing research in this field is deficient in providing a comprehensive assessment of the entire lifecycle of submarine landslide hazard chains.  This research aims to understand the complex geophysical processes that cause submarine slopes to evolve and fail in the context of overpressured fluid transport in marine sediments, addressing a critical gap in our understanding of submarine slope instability and has important implications for fundamental geophysics, risk assessment, and climate change.  To achieve our objectives, we will characterize the physical and mechanical properties of seabed geological bodies and fluids and develop a coupled Computational Fluid Dynamics (CFD) model with the Random Field Theory approach to capture the material heterogeneity in the micro- and macro-scales (WP1), conduct laboratory-scale experiments for obtaining quantitative parameters and use CFD method to study submarine slope failure caused by overpressured fluid transport,  reproducing the life cycle process of submarine landslides (WP2), develop a highly scalable numerical model based on the open source code Hydro3D to evaluate the impact of submarine slope failure on infrastructures and the submarine environment using field observation data (WPs3-4), and ultimately implement comprehensive training activities and IP transformation, and develop an int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'QUantum reservoir cOmputing based on eNgineered DEfect NetworkS in trAnsition meTal dichalcogEnides'.

assistant: **Concept**

Today’s computation, based on parallel processing of information, is reaching its physical limitations and novel solutions are to be found in the close future to overcome such major hurdle. This project aims to achieve the first proof-of-concept of Quantum Reservoir Computing (QRC) scheme based on networks of Quantum Materials (QMs) defects which will enable the fabrication of prototypical computing devices. The engineering of defect network characteristics such as density and defect typology will allow tailoring the defects’ network physical properties, and ultimately its neuromorphic and computing complexity. The project is feasible yet groundbreaking because it capitalizes upon the very different expertises, both experimental and theoretical, comprised within the partners’ consortium, all of which are required to implement a novel QRC scheme. As such, this project will result in unprecedented characteristics that extend the conventional boundaries of ICT electronic devices and systems and pave the way for the development of novel Quantum Technologies.


**Keywords:** Quantum Technologies, Quantum optics, quantum reservoir computing, transition metal dichalcogenides, singlephoton emitters, optical spectroscopy, hyperspectral imaging
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Artwork Unique RecognitiOn and tRacking through chemicAl encoded data, miniaturized devices and blockchain alliance' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Artifacts are constantly threatened by anthropogenic actions. Looting, smuggling, and illicit trade of cultural goods pose major risks to our cultural goods and our cultural identity. One of the major consequences of these illegal activities is the dissociation, meaning the loss of information associated with an object, such as provenance, identification, or location information, without which the object loses significance or is lost. Thus, art property marking and tracking are crucial to ensure the object identification, collection management and protection, while maintaining their state of conservation. Several actions have been adopted during the years to strengthen the protection of cultural property and cultural heritage, but they often lack effectiveness. The AURORA project wants to fill this gap by demonstrating how chemical marking, miniaturized device, art deep-scan technique, cloud and blockchain based platforms can be combined to create a cost-effective, non-destructive, and non-invasive countermeasure against illegal activities while preserving artifacts. The technologies researched and implemented in AURORA will converge in a digital tool allowing relevant stakeholders, art dealers, curators, auction houses, logistic services, and enforcement agents, to easily verify artwork authenticity and provenance, enabling art piece movement tracking. In close collaboration with relevant cultural institutions partners, AURORA will showcase real setting applications to validate the non-invasiveness, low cost, long-term stability, confidentiality, and data security features of the proposed solutions. In parallel, AURORA will foster technological democratization among cultural institutions, by creating a knowledge bridge between technical competencies and cultural herita
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular basis of the cross-talk between chronic inflammation and cancer' (CrIC) under Horizon 2020.

assistant: **Objectives**

Cancer related inflammation (CRI) is a well-established hallmark of cancer. We recently demonstrated that the DNA damage repair SLX4 complex suppresses spontaneous and human immunodeficiency virus (HIV)-dependent pro-inflammatory cytokine production, revealing a role for this DNA repair complex in controlling innate immune responses. Bi-allelic mutations in SLX4 are involved in the onset of Fanconi Anemia (FA), a syndrome characterized, besides heightened cancer susceptibility, by severe defects of the immune system, resulting from increased pro-inflammatory cytokine levels and progressive bone marrow failure. Within this proposal, using SLX4-deficiency as a working model, I aim at investigating the molecular process underlying CRI. Based on our previous observation that the SLX4 complex binds to HIV-derived reverse-transcripts and promotes their degradation, my working hypothesis is that CRI results from the accumulation of endogenous pathological nucleic acids that are recognized by the innate immune system in the absence of SLX4. The present project should unveil the relationship between repression of pro-inflammatory cytokine production by proteins involved in DNA repair, DNA damage, and CRI, thereby opening unforeseen perspectives in the treatment of cancer patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tackling the Achilles Heel of Immunotherapy: Validating imaging biomarkers and targeting the immunological niche of tumour hypoxia' (HYPOXIMMUNO).

assistant: **Innovation**

Lung cancer is the most common cause of death from cancer worldwide with 1.59 million deaths annually and it places the highest economic burden of all cancers on the EU at €18.8billion. These figures call for a major transformation of the therapeutic management of lung cancer. The recent developments in immunotherapy give new hope. At present a significant minority of patients benefit from immune therapy, which remains not curative when delivered alone. It is thus clear that improving the efficacy of immune therapy is needed as well as the identification of predictive biomarkers. Combining immunotherapy with radiotherapy improves effectiveness, but resistance is still common, most probably because of hypoxia. In HYPOXIMMUNO, we will open up a new paradigm in treating metastatic NSCLC. I will provide for the first time (pre)clinical proof of concept of (i) highly innovative CT-based radiomics and PET-hypoxia imaging patient stratification tools and (ii) a tri-modal curative hypoxia-targeting treatment strategy that complements current immunotherapy and radiotherapy approaches. This tri-modal curative treatment strategy is based on (1) high precision Stereotactic Radiotherapy (SABR) to kill cancer cells and trigger the immune system, combined with (2) a hypoxia-activated prodrug to target the hypoxic tumour cells resistant to immunotherapy and (3) a promising and innovative tumour specific antibody (Ab)-based immunotherapy (immunocytokine L19-IL2 to “push the accelerator” with or without a checkpoint inhibitor to “release the break”) to form a powerful synergistic immuno-oncology strategy. In HYPOXIMMUNO, I envision to lay the foundation for the next breakthrough in oncology, by improving patient selection and developing highly innovative cancer therapies that target hypo