RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Targeting human kallikreins involved in ovarian cancer pathogenesis: novel activity based probes and kallikrein-based therapeutic strategies.'.

assistant: **Concept**

Ovarian cancer (OvCa) is one of the most fatal female gynaecological malignancies, resulting in 180,000 deaths annually. The majority of patients have metastatic disease at time of diagnosis, thus, early diagnosis of OvCa remains a challenge to our society. In addition, the low survival rates over the past decades have remained largely unchanged, evidencing the need of new therapies for OvCa. Kallikrein-related peptidases (KLKs) are a family of 14 serine proteases which form a cross activation network known as the KLK activome. KLKs show diverse tissue expression and physiological function, and aberrant KLK expression and activity has been related to several pathological conditions including skin diseases, neurodegenerative disorders and cancer. In OvCa, KLKs4,5,6 & 7 levels are upregulated and associated with its unfavourable prognosis, therefore, KLKs4,5,6 & 7 are considered potential drug targets and biomarkers for OvCa. However, KLK activity is decoupled from simple abundance, and the contribution of each KLK activity in OvCa progression remain poorly understood. In this project, I will develop selective (quenched)-Activity Based Probes ((q)-ABPs) for KLKs4,5,6 & 7 and quantify the active enzyme fraction of each KLK to determine their contribution to OvCa. Additionally, I will develop proteolysis targeting chimeras (PROTACs) which can be selectively activated by specific KLKs to unlock their potential as therapeutic targets for OvCa. This proposal aims to deliver a versatile platform to interrogate the application of KLKs4,5,6 & 7 as biomarkers and therapeutic targets for OvCa, with potential application to other KLK- and serine protease-related disorders. My participation in this proposal will allow to bring key knowledge to face the challenging objectives and rece
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'European Connected Factory Platform for Agile Manufacturing'.

assistant: **Concept**

The EFPF project realises a federated smart factory ecosystem by primarily interlinking 4 smart factory platforms, from the FoF-11-2016 cluster, through an open and interoperable Data Spine. The federation of the 4 base platforms is complemented by industrial platforms, collaboration tools and smart factory systems, specifically selected to support connected factories in lot-size-one manufacturing. The federated EFPF platform delivers enhances value and reduces the barrier to innovation by providing seamless access to services and solutions that are currently dispersed. In parallel the platform provides the necessary infrastructure, tools and support for novel service creation and validations by third parties. Further, by fostering healthy competition in the smart factory ecosystem, the EFPF platform will ensure that the needs of the evolving smart manufacturing industry are met for the long term. The EFPF federation is offered to the manufacturing and logistic companies as an open platform; to utilise the offered functionality, experiment with innovation approaches and develop custom solutions based on specific needs. The project demonstrates the power of federation through 3 embedded large scale pilots focusing on lot-size-one manufacturing and sustainable value networks in diverse sectors, while a cross sectorial circular economy pilot is also incorporated. The results of the pilots are openly made available as lessons learned and best practices. The creation of the European smart factory ecosystem is supported by offering interested companies technical and financial support. A dedicated budget is allocated to offer financial support to companies who are interested in using the EFPF platform to enhance their businesses. The project is primarily composed of SMEs who h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sound Exposure and Risk Assessment of Wireless Network Devices', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Public exposure to electromagnetic fields in the radio frequency spectrum has increased dramatically in the last two decades. Although research has mainly focused on the exposure and health risk evaluations of cellular networks and mobile phones in recent years, studies on the effects of the pervasive and prolonged EMF exposure on human health due to the exponential growth of wireless network device usage in homes, offices and schools are lacking. The proposed project SEAWIND aims (1) to provide a comprehensive assessment of the incident field exposure in typical living scenarios such as in homes, offices and classrooms by installed wireless local area networks (WLAN or WiFi) or wireless metropolitan area networks (WMAN or WiMAX), body-mounted and body-worn wireless personal area networks (WPAN) and WLAN devices, and specific wireless applications in industry, e.g., novel RFID logistic applications; (2) to numerically determine the induced fields in the human body using a set of models representing the human population; and (3) to screen potential biological sensitivities at the molecular, developmental and functional levels in cells. The necessary technology will also be developed to accurately assess the exposures for device compliance testing and to accurately assess in situ exposures. The comprehensive risk assessment will be based on the findings of this project, addressing the specificity of the exposure of wireless networks combined with the current body of literature on biological interactions of EMF covering the entire radio-frequency spectrum. A comparison to other exposures such as cellular mobile devices, base stations, TV, Radio, etc will also be included.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CHAlleNging Gender (In)Equality in science and research' in the context of a Horizon 2020 call.

assistant: **Objectives**

The main aim of CHANGE – “CHAlleNging Gender (In)Equality in science and research” is it to support research organisations to implement gender equality plans, this will be achieved by involving key actors, called transfer agents, within each organisation who will together with the core consortium partners transmit the co-produced gender equality knowledge inside their institution. This innovative approach will ensure the promotion and sustainable institutionalization of the gender equality plans (GEPs) beyond the project duration. Through mutual learning and networking CHANGE will enable partners to become resource centres skilled to provide knowledge and expertise to individuals or departments that will be available for experience exchange, support and mentorship in the country and region after the project is finished. Regular inclusion and exchange with national and European stakeholders (policy makers, researchers, ministries etc.) ensures a spill-over effect of CHANGE results to other research performing organisations (RPOs) and research funding organisations (RFOs) in their respective countries as well as with other ministries in the whole European area. Thus CHANGE contributes to the advancement of gender equality in the European Research Area by stimulating institutional cultural change towards gender equal work environments in RPOs and fostering the importance of gender dimension inclusive research and innovation programmes in RFOs.


**Keywords:** Gender (In)Equality, Research Ogranisations, Gender Equality Action Plans, Transfer Agents
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Origins of Alzheimer's disease across the life-course', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The origins of Alzheimer’s disease (AD) remain elusive. The long pre-clinical phase of AD is universally recognized, but it is not known when predisposition for AD develops nor when the first signs and symptoms become discernable. In this regard, an essential role is played by the ‘reserve’ capacity of the brain, which is built up in early life and acts as buffer against adverse risk factors later in life. However, life-time trajectories of build up and loss of reserve and its determinants remain poorly understood.In ORACLE, I aim to unravel the origins of AD by studying reserve across the entire life-span: from in utero to end of life. The underlying hypothesis is that etiologic factors exert their effect on the risk of AD during the entire life-span, through build-up and loss of reserve. Such life-course approach to study reserve is worldwide unique and constitutes truly ground-breaking research aimed at unraveling the earliest origins of AD. Key objectives are:1) To study trajectories of reserve across the entire lifespan.2) To study factors that shape reserve in early life.3) To study factors that determine onset and early loss of reserve.I will compile a life-course cohort that consists of three population-based samples totalling 40,829 persons that together cover the entire life-span: children in Generation R Study (in utero – 18 yrs); parents in Generation R Study (18–45 yrs); and the Rotterdam Study (45 yrs – death). Reserve will be quantified structurally using imaging techniques that measure volumetry, perfusion and connectivity as well as functionally by measuring cognitive and non-cognitive brain functions. I will study genetic and non-genetic risk factors of AD and their effects on reserve.Results from ORACLE will provide ground-breaking new insights into t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Social Enterprise as Force for more Inclusive and Innovative Societies (seforïs)' (SEFORIS) under Seventh Framework.

assistant: **Objectives**

The “seforïs” research project seeks to understand the potential of social enterprise in the EU and beyond to improve social inclusiveness of society through greater stakeholder engagement, promotion of civic capitalism and changes to social service provision through a) investigation of key processes within social enterprises for delivering inclusion and innovation, including organisation and governance, financing, innovation and behavioural change and b) investigation of formal and informal institutional context, including political, cultural and economic environments and institutions directly and indirectly support social enterprises. The methodology will be to start from policy and social enterprise practitioner issues to develop a theoretical framework for inclusion and innovation processes in context, followed by novel experimentation with social enterprises and in depth case study analysis to expand and enrich. Longitudinal survey data will be used to test and validate conclusions. Representative policy makers and social enterprises will be engaged throughout the process to ensure relevancy and transmission of results and findings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generalized Hilbert space compression and coarse geometry of data sets' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Metric spaces, such as graphs, occur everywhere in mathematics and are used to model real life situations: in computer science e.g., they are used to model computer networks and in sociology, graphs are used to model interhuman relations.In order to study metric spaces, one can embed them into an object which one understands quite well. The information that we know on the latter object may then provide useful information on the embedded metric space. A Hilbert space is a well understood mathematical object which can be studied by algebraic techniques (it is a vector space, with an inner product), by analytic techniques (least square methods) and by many more tools.Around the 1990s, Gromov introduced the notion of metric spaces that `embed uniformly' into a Hilbert space. This relatively weak condition turned out to be connected with some major conjectures: it implies the coarse Baum-Connes and Novikov conjecture in the case of finitely generated groups. The equivariant version of uniform embeddability is Haagerup's property, a property with clear connections to the Baum-Connes conjecture and a subject of intense study.Guentner and Kaminker define the (equivariant) Hilbert space compression of a f.g. group as a number between 0 and 1 which quantifies how ""well"" the group embeds uniformly into a Hilbert space (is Haagerup respectively). Moreover, they showed that if the value of the (equivariant) compression is strictly greater than 1/2, then the group has Yu's property (A) (is amenable respectively). This shows that the compression notions contain important information on the group, making them very interesting to study.This Marie Curie project fits in this setting. We intend to study compression through new techniques such as persistent cohomology, determine the relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Revealing the composition and formation mechanism of carcinogenic asbestos bodies in human lungs' under Horizon 2020.

assistant: **Concept**

When it is inhaled, asbestos triggers a chain of events that can lead to mesothelioma, an aggressive cancer of the lung lining, and to lung cancer. After prolonged stay in the lungs the asbestos fibers develop an iron coating that is thought to be responsible for the cytotoxic response, and which nature is still unclear. The fibres with their coating, developed after prolonged stay in human lungs, are known as asbestos bodies. Despite the large and increasing incidence of respiratory/pulmonary diseases among the general population due to asbestos and other toxic fibers, the carcinogenic mechanism is not yet fully understood. A deeper knowledge of the interaction between the fibers and the biological tissue can help scientists to develop more efficient medical treatments and to improve prevention strategies. The proposed research project aims to reveal the composition and formation mechanism of asbestos bodies combining cutting-edge synchrotron radiation fluorescence and imaging microtomography and microdiffraction with transmission electron microscopy. Synchrotron radiation techniques will allow revealing the elemental distribution and morphology of unaltered lung tissue samples with unprecedented level of detail, preserving their tridimensional structure. Microdiffraction and transmission electron microscopy will reveal possible degradation of the embedded asbestos fibres, which is a long standing question. The project will exploit an innovative collaboration between physicists, chemists, doctors, and biologists. In particular, physics techniques usually employed in the field of fundamental research or in material science will be combined with laboratory methodologies, creating an environment favourable for breaking-through results. The methodologies developed during t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Measurement of state of mixture of black carbon in atmospheric aerosol' (BLACKCARBONMIX), addressing dissemination and exploitation.

assistant: **Impact**

Black carbon (BC), the predominant source of solar absorption in atmospheric aerosol, can be present therein as pure BC particles distinct from purely scattering particles (external mixture), homogeneously mixed with purely scattering components (homogeneous internal mixture) or as BC core particles coated with scattering components (coated internal mixture).Depending on the assumption on the state of mixture in a climate model, the resulting radiative forcings range from negative (cooling) for external mixtures to potentially as positive (warming) as for the greenhouse gas methane for coated internal mixtures on global average. The assumptions on the BC state of mixture made in the models can currently not be verified in the atmosphere as there is no method to measure the BC state of mixture. This proposal will provide a method to measure the BC state of mixture while following an air parcel in order to study the temporal evolution of the BC mixture state.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Social Epistemology of Argumentation'.

assistant: **Objectives**

Argumentation -the practice of giving and asking for reasons to support claims - is a key component of scientific inquiry, legal procedures, and political life. But in many instances, argumentation does not achieve its presumed goal of fostering consensus and circulation of reliable information. Recent events in world politics - Brexit, US elections, refugee crisis - demonstrate that a better grasp of what argumentation can and cannot do for us is urgently needed.The key question of this project is: ‘what does it take for a process of argumentation to improve our epistemic situation?’ Prior theories fail because they are based on overly idealized assumptions. This project develops a more realistic approach: argumentation is viewed as a practice interwoven with power relations, occurring in situations of epistemic and social diversity, and involving agents who are not ‘purely rational’. We will formulate the first comprehensive account of the social epistemology of argumentation, i.e. of the role of argumentation in processes of circulation and production of knowledge, evidence, and justification. To this end, we will bring together two research traditions that so far remain largely disconnected: social epistemology and argumentation theory. Our innovative hypothesis is that argumentation is a form of social exchange that can be successful to various degrees. What is exchanged are epistemic resources such as knowledge, evidence, justification, critical objections. Insights from social exchange theory will inform the investigation, a suitable framework for our purposes because it emphasizes the interplay between self-interest and interdependence. The result will be a realistic theory of the processes through which epistemic resources are shared and produced through argume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '2-generator discrete groups and hyperbolic orbifolds' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This project deals with the classification problem of 3-dimensional hyperbolic orbifolds or equivalently, the classification problem of discrete subgroups of PSL(2, C) which is isomorphic to the isometry group of the hyperbolic 3-dimensional space. We concentrate on 2-generator groups and orbifolds. The first part is dedicated to finding criteria (necessary and sufficient conditions) for discreteness of 2-generator subgroups of PSL(2,C) without invariant planes.The project is aimed to obtaining criteria that are convenient for different applications in algebra and topology. In the second part the aim is to describe all hyperbolic 3-orbifolds, i.e., to present their singular sets and the underlying spaces and to give conditions when such orbifolds exist. Another question arising here isto establish when an abstract group can be the fundamental group of a (hyperbolic) 3-orbifold. For example, hyperbolic 3-orbifolds are closely related to generalised triangle and tetrahedron groups. We plan to develop further connections between these objects.