RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Simulating electronic dynamics with Quantum Trajectories by combining exact factorization and Density Functional Theory' (QT-DFT), addressing dissemination and exploitation.

assistant: **Impact**

The quantum mechanical simulation of time-dependent (TD) phenomena is relevant for many technological and medical applications, as in solar cells design, control of radiation damage in biomolecules, photocatalysis, nanoscale conductance devices, and quantum computers.With this proposal, the candidate intends to overcome the most critical limitations of current methods for the calculation of electronic dynamics  - most notably of TD Density Functional Theory (DFT) - by pioneering a combination of (1) innovative density functional approximations and (2) an algorithm for time-propagation that treats one electron semi-classically. The common thread linking these parts is the so-called exact factorization, an overarching strategy that has been used by both the candidate and the supervisor in the contexts of DFT and molecular dynamics (MD), respectively. According to this strategy, the wavefunction is rewritten as a product of a “marginal” and a “conditional” amplitude and the corresponding Schrödinger equation is conveniently expanded into two coupled equations, providing a clear decomposition of the chemical environment. Joining together the candidate's expertise in fundamental DFT and the supervisor’s expertise in trajectory-based approaches, the algorithm that will be developed takes inspiration from the method elaborated by the host for ab initio MD simulations and adapts and supplements it in a way suitable to treat the motion of electrons. The project includes validation of the algorithm on simple electronic structures (simple atoms/molecules), whose static and dynamical densities and potentials are computationally accessible and can serve as benchmark. The end goal of the project is to develop a reliable and computationally practical method for the simulation of ultra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Transcriptional and Epigenetic Regulation of Totipotency in Mouse Early Embryos.'.

assistant: **Innovation**

In mammals, fusion of two highly differentiated gametes gives rise to a totipotent zygote capable of developing into a whole organism. It coincides with translation and degradation of maternally provided transcripts, initiation of global transcription called zygotic genome activation (ZGA), and “epigenetic reprogramming” of germline chromatin states into an embryonic state. The molecular mechanisms underlying this exquisite reprogramming of cell fate are barely understood. This research program has the ambitious goal to identify and characterize in a comprehensive way the transcription factors and chromatin regulators which initiate and regulate ZGA in a parental specific manner in early mouse embryos. We will utilize novel and highly sensitive genomic approaches to measure nascent transcription and determine open and modified chromatin landscapes in oocytes and early embryos, wild-type and conditionally deficient for major epigenetic modifiers. We will apply computational approaches to identify candidate TFs and histone modifiers controlling ZGA. We will use molecular and developmental biology approaches, combined with sensitive quantitative live-imaging, to interrogate the function of TFs and their binding sites for ZGA.We will further investigate the significance of possible paternal inheritance of nucleosomes at CpG islands for gene regulation during ZGA and later development by depleting nucleosomes from mature sperm by using sophisticated conditional deficiency and gain-of-function mouse models. By transferring nuclei of immature spermatid and mature sperm into oocytes, we will interrogate the relevance of nucleosome eviction during spermatogenesis, as a possibly truly epigenetic reprogramming process, for defining embryonic competence. ERC funding would represent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deep surveying of CNV impact on Mouse transcriptome complexity and regulation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a comprehensive understanding of the phenotypic effect of these structural variations is only beginning to emerge. An extensive map of CNV in wild mice and inbred strains has been established by the host group. These variable regions cover ~11% of their autosomal genome. CNVs are suggested to shape tissue transcriptomes on a global scale and thus represent a substantial source for within-species phenotypic variation. In this context, we address three major research objectives all regarding the impact of structural variants on different aspects of the transcriptome. To unravel the effects of CNVs on expression at the nucleotide rather than locus level we propose to use RNA-seq to monitor expression changes of both coding and non-coding RNAs that map to or close to genomic regions that vary in copy numbers in multiple tissues of the three mouse inbred strains (129S2, DBA/2J, C57BL/6J). These will be compared to changes in the abundance of transcripts that lie outside of CNV regions. Secondly, we will use RNA-seq data to identify and characterize alternative splicing events that are either tissue- or strain-specific, as well as determine whether copy number polymorphisms affect this process. Thirdly, we will investigate allelic imbalance at genome-wide scale and check if this phenomenon is more likely to occur in CNVs. This work should (i) give an unprecedented global and precise view of the mouse transcriptome; (ii) produce the first transcriptome comparison at the nucleotide level of normal individuals of a population; (iii) help to gauge the influence of CNVs on the transcriptome and (iv) provide the first assessment of allelic imbalance at genome-wide sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Hydrogen interaction with polycyclic aromatic hydrocarbons – from interstellar catalysis to hydrogen storage'.

assistant: **Concept**

In a truly cross-disciplinary research project encompassing surface science, astrophysics and chemistry we aim to address two of the major outstanding questions in the field of astrochemistry, namely i) how molecular hydrogen, the most abundant molecule in the interstellar medium, form, and ii) whether it is possible to identify specific Polycyclic Aromatic Hydrocarbon (PAH) species in interstellar spectra. The insights gained from the experimental investigations may revolutionize our current understanding of astrochemistry and will have impact even beyond the field. Special emphasis will be placed on the impact our findings will have on ascertaining the suitability of PAHs as a hydrogen storage medium. By combining scanning tunneling microscopy, thermal desorption spectroscopy, laser-induced thermal desorption time-of-flight mass spectrometry, fluorescence spectroscopy experiments and density functional theory calculations we will map out the interaction of atomic hydrogen with PAHs. The goal of the investigation is to obtain atomic level understanding of the atomic hydrogen – PAH interaction in order to i) ascertain whether interstellar molecular hydrogen formation, contrary to present belief but in accordance with our recent calculations, could occur predominantly via interaction with PAHs, ii) measure the adsorption/emission spectrum of Hydrogen-PAH complexes and thereby facilitate observational detection of these complexes in the interstellar medium, iii) determine whether PAHs are a promising medium for hydrogen storage and iv) ascertain whether the hydrogen storage properties of PAHs are tunable by electro-magnetic radiation. This ambitious and cross-disciplinary research project will predominantly take place at the newly established Surface Dynamics Laboratory a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DigitalHealthEurope: Support to a Digital Health and Care Innovation initiative in the context of Digital Single Market strategy' to be submitted under Horizon 2020.

assistant: **Abstract**

DigitalHealthEurope will provide comprehensive, centralised support to the digital transformation of health and care (DTHC) priorities of the Digital Single Market. The partners bring a broad range of collective knowledge and expertise, originating from the longstanding leadership and engagement in the whole spectrum of activities, from interoperability and standards to health service innovation and from the technical to the policy level. The project will support large-scale deployment of digital solutions for person-centred integrated care by identifying, analysing, and facilitating the replication of highly impactful best practices, utilising the consortium’s exceptional expertise on knowledge management and impact assessment (EIP on AHA repository of innovative practices, MAFEIP), twinning schemes, and mobilisation of stakeholders. A marketplace will enable organisations to find suitable partnerships. At least 46 twinnings ranging from adaptation of impactful best practices to full adoption will be carried out. A funding advice service and capacity building framework will be provided to further stimulate deployment and scale up. Building on the unique composition of the consortium, the project will establish and manage 3 collaboration platforms to align all efforts of ongoing and future initiatives supporting the 3 DTHC priorities. The partners will utilise their vast network of more than 1,100 members representing national, regional, and EU-wide stakeholders. The collaborative work will lead to common strategic agendas and commitments for action that will boost innovation and progress in the respective topics. A Board of Associated Experts with proven high-level competence on all key fields will support the delivery of an actionable strategic vision and recommendati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Degradation of Lifetime of fuel cell Resistance by Electrochemical impedance Spectroscopy' under Horizon 2020.

assistant: **Concept**

Solid Oxide Cells (SOCs) should form an important part of any future energy mix, due to their flexible operation andscalability. One barrier to their wider adoption is the degradation of SOC components and operational lifetimes need toincrease by a factor of up to 10 to make them commercially viable. Degradation of the fuel electrode (anode) is welldocumented and fairly well understood; degradation at the oxygen electrode (cathode) has only recently attracted morescientific research and is far less understood.The purpose of this Fellowship is to better understand the degradation that takes place at the Yttria-Stabilised Zirconia (YSZ)electrolyte and La0.8Sr0.2Mn03 (LSM) cathode interface, as this has been cited as ‘one of the most serious degradationproblems in Solid Oxide Fuel Cells (SOFCs)’. A new degradation mechanism involving YSZ has very recently been identifiedat the host institution and its investigation forms the basis of this application. Assuming that a solution to this degradation canbe proposed, the project will have major impacts on the SOFC community and commercial SOFC development. The Fellow,Dr Vendrell, will be supervised by a multi-disciplinary team of experienced researchers, who between them can guide andtutor him in areas relevant to this project: ie materials synthesis and fabrication; electrical property measurements;microstructural characterisation; fabrication of YSZ films using tape casting technology; spectroscopic characterisation andmodelling of materials; in operando and ex-situ analysis of degradation in working SOFCs.The Fellow will build on his previous experience in the area of lead-free ferroelectrics to develop in-depth understanding ofthe electrical properties of YSZ electrolyte, and be trained in state-of-the-art SOC methodology. H
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fens Winter School: Nervous System Reaction to Neuronal Loss and Injury'.

assistant: **Objectives**

Neuronal loss and injury is one of the major problems in current neurology. There is an urgent need for therapies that are currently not yet available. However, modern molecular neuroscience has recently lead to exciting new insight into mechanisms that are involved in neuronal cell death. Therefore, a special training of promising young scientists in the field should have a major impact on the development of science in this field towards new therapies.The discovery of new mechanisms and molecules that are involved in neuronal development, differentiation, cell death as well as degeneration and regeneration has tremendously emerged in recent years. A variety of new hypotheses is currently under investigation with impact on the development of new therapeutic strategies in treating injury of the nervous system. This school on NERVOUS REACTION TO NEURONAL LOSS AND INJURY shall train young scientists in one of the most important rapidly developing fields in neuroscience. The scientific originality is ensured by the participation of the leading scientists in the field of neuronal loss and injury.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00160-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The baryonic and chemical content of disc galaxies: A key to galaxy formation' (BACON) targeting Sixth Framework.

assistant: **Abstract**

The presently favoured Cold Dark Matter cosmology still faces serious discrepancies with observations on galactic scales. Baryon physics can give a crucial contribution to improve the predictions of cosmological simulations. A key to understand galaxy form ation and evolution is to measure the baryonic content of galaxies: compared to the universal baryon fraction, it reveals if galaxies expel large amounts of the available baryons via stellar energy feedback. Disc galaxies are especially interesting because feedback is fundamental to explain their sizes and angular momenta. Also, the mass of baryons in discs is crucial to derive the density profiles of dark matter haloes, a puzzle for current cosmology. To know the mass of baryons in galaxies we must know th e mass-to-light (M/L) ratio of their luminous stellar component. Accurate data are available for the stellar populations in the Solar Neighbourhood, and we will interpret them with chemo-photometric models to derive the stellar M/L ratio in the local Galac tic Disc. We will then apply the models to external disc galaxies, and by combining chemo-photometric and dynamical analysis we will investigate the stellar M/L ratio as a function of Hubble type, of galaxy mass and in high vs. low surface brightness discs . We will infer how star formation and feedback work in different objects, so that we can include realistic baryon physics in cosmological simulations and improve our understanding of galaxy formation. Our chemical models will also predict the helium conte nt of nearby stars, and the relative helium-to-metal enrichment rate DY/DZ. We can also probe this quantity observationally, from the colour-magnitude diagram of a large sample of nearby low Main Sequence stars. From DY/DZ we can then infer the primordial hel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Empowering Solutions and Technologies for Older people to Retain Everyday life activities' (NESTORE) under Horizon 2020.

assistant: **Objectives**

Ageing population is growing faster in EU. ICT can provide solutions for Active Ageing, however the success of novel ICT solutions depends on the user perception about their efficacy to support toward health promotion and global wellness.NESTORE will develop an innovative, multi-dimensional, personalized coaching system to support healthy ageing by: 1) Generating and sustaining motivation to take care of health; 2) Suggesting healthy nutrition and personalized physical and mental coach, as well as social interaction, to prevent decline and preserve wellbeing.The main concept is to develop NESTORE as a friend and a coach able to support both the individual and the social dimension. The friend NESTORE understands the emotional status of the user; the coach NESTORE understands the “weaknesses” of the user and proposes actions and activities that improve and maintain wellbeing. Key innovation element in NESTORE is the design of “pathways of interest” able to provide hints and services according to the user’s preferences, while ensuring that the overall wellbeing and health status is maximised.NESTORE leverages on novel ICT technologies: 1) multi-domain unobtrusive monitoring system, including wearable and environmental sensors and tangible objects, 2) intelligent Decision Support System, to analyse the seniors’ behaviour and provide personalized targets toward wellbeing 3) active coaching, developed as conversational agent, embodied in a physical companion that assumes different forms, able to establish affective communication through multimodal communication channels and to engage older people with personalized coaching activities in a single or multiple domains. Methodological strengths of our approach are: 1) co-design research adopted throughout the project 2) thorough
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a process to generate a novel plant protection product enriched with micronutrients to replace copper in organic viticulture' (ProEcoWine).

assistant: **Concept**

We are a Trans-European partnership of 6 SMEs from 5 EU Member States planning to develop a novel bio-fungicide to treat common grapevine fungal diseases.  Across Europe, the fungal diseases downy mildew and botrytis cause problems in all vineyards, reduce yield and impair wine quality. Current methods of treating these diseases in traditional farming and particularly organic farming require the use of copper fungicides. However, their use is now limited in Europe by Council regulation (EEC) No 2092/91. This limits the efficacy of fungicides, decreases yields and increases wine production costs.  Our innovative microalgae plant protection product enriched with micronutrients will enable the replacement of copper fungicides in organic and conventional viticulture, increase yield in organic vineyards by up to 30% and decrease production costs per unit by up to 20%. This will increase the competitiveness of EU wines and support the development of the organic market in Europe.  Within 6 years of project completion and after 5 years of marketing our product, we anticipate a 16% share of the fungicide market for our primary application (treatment of downy mildew and Botrytis in grapevines) which will be sales of an estimated €52 million.