RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Methods in Computational Finance' (STRIKE).

assistant: **Innovation**

In recent years the computational complexity of mathematical models employed in financial mathematics has witnessed a tremendous growth. Advanced numerical techniques are imperative for the most present-day applications in financial industry.The motivation for this training network is the need for a network of highly educated European scientists in the field of financial mathematics and computational science, so as to exchange and discuss current insights and ideas, and to lay groundwork for future collaborations.Besides a series of internationally recognized researchers from academics, leading quantitative analysts from the financial industry also participate in this network. The challenge lies in the necessity of combining complementary techniques and skills such as mathematical analysis, sophisticated numerical methods and stochastic simulation methods with deep qualitative and quantitative understanding of mathematical models arising from financial markets.The main training objective is to prepare, at the highest possible level, young researchers with a broad scope of scientific knowledge and to teach transferable skills, like social awareness which is very important in view of the recent financial crises.The current topic in this network is that the financial crisis in the European countries is a contagion and herding effect and is clearly outside of the domain of validity of Black-Scholes and Merton's theory, since the market is not Gaussian and it is not frictionless and complete.In this research training network our aim is to deeper understand complex (mostly nonlinear) financial models and to develop effective and robust numerical schemes for solving linear and nonlinear problems arising from the mathematical  theory of pricing financial derivatives and related
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Self-Assembly, Structures and Interactions of Cell Specific Cytoskeleton', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cell specificity plays a critical role in the complexity high-order organism can achieve.  The cascade of signals and events leading embryonic stem-cells to differentiate has been a major research topic in the last century. During differentiation, cell-specific proteins are expressed in order to accommodate the necessary specific functions. Among other cell/tissue specific modulations, the cytoskeleton is altered during differentiation and at different developmental stages of a specific cell type. This is presumably to account for the constantly-changing mechanical strains and stresses, as well as interactions with the environment, intracellular transport and cell motility.We propose to study a class of cytoskeleton proteins, named intermediate filaments, which are expressed at various developmental stages and cell/tissue types of neuro-muscular origin. Interdisciplinary studies will include protein purification, biochemical characterization, high-resolution microscopy, as well as structural studies in hydrated state using small-angle x-ray scattering. Combining these multiple techniques, we aim to model and reveal how minor molecular differences between proteins from the intermediate filament family are translated into supramolecular forces that, in turn, alter the cytoskeleton elastic and mechanical properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Wireless deployable network system' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The purpose of WIDENS is to design, prototype and validate a vertically integrated rapidly deployable and scalable communication system for future public safety, emergency and disaster applications. The project focuses on designing a single hot spot, which can be easily deployed, optimised for high bitrate throughput (over 2Mbit/s) and interoperable with existing core networks and present private mobile radio systems. The system concept is based on ad hoc network technologies, and the technological approach focuses on adaptations of existing technologies for the purposes of meeting the public safety requirements.The target terminal nodes will include both physical, link and network routing layers, and will feature asynchronous and synchronous high bitrates, direct mode group communications, strong authentication and confidentiality and quality of service. The project will support the strong on-going European involvement in the joint ETSI/TIA standardisation initiative MESA (Mobile Broadband for Emergency and Safety Applications). The design and prototype developments will be contributed to the MESA standardisation process and will shape the future of private mobile communication systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'On the reduction of health effects from combined exposure to indoor air pollutants in modern offices'.

assistant: **Concept**

Modern offices usually have several sorts of electronic equipment and other dominant heat sources indoors, making them almost unaffected by local climatic conditions. Air conditioning and mechanical ventilation coupled with the often excessive levels of artificial lighting, require high levels of energy. At the European Union (EU) level, the Directive 91/2002, (EPBD), is a major step towards rational energy use. An important issue to consider regards IAQ. It is anticipated that developments in the field of energy use in offices will lead to its reduction through various strategies, including comfort/health standards and ventilation levels. In such a context and given the technological evolution of the functions and services accomplished in offices, it is time to address the issue of IAQ in offices. The participants of this proposal are fully aware of the issues described above and, particularly, of the difficulties to launch solid policies on IAQ, both generally and specifically in offices, related simultaneously to ventilation, energy and health. The uncertainties that justify those difficulties are derived from the lack of information regarding the toxicity of a number of compounds that pollute indoor air. Furthermore, the lack of knowledge of their indoor concentrations and exposures in the current conditions means that the real impact of these compounds on IAQ, comfort/ health and productivity in offices is unknown. The overall objective of the OFFICAIR proposal is twofold. Firstly, to establish a framework that will provide new knowledge in terms of databases, modelling tools and assessment methods towards an integrated approach in assessing the health risk from indoor air pollution, focusing on modern office buildings. Secondly, to support current EU policies, suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Specific and non targeted effects of a two-dose strategy with stand ard measles vaccine. Implications for immunization programmes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The general objectives are:* To reduce childhood mortality in developing countries through better control of measles infection by developing a better immunization strategy.* To investigate the hypothesis that standard titre measles immunization is associated with non-targeted beneficial effects on childhood morbidity and mortality in developing countries.The measurable, specific objectives are:* To examine whether a two-dose strategy for measles immunization at 6 and 9 months of age can reduce measles incidence by 50% through better coverage or improved seroconversion.* To examine whether a two-dose strategy for measles immunization at 6 and 9 months of age can reduce childhood mortality by 20% through better coverage, better protection against measles or non targeted beneficial effects.* To determine the magnitude and duration of non-measles related changes in morbidity patterns after standard titre measles immunization, in particular to test whether measles immunization is associated with a 15% reduction in the risk of diarrhoea.* To determine non-measles related immunological changes among recipients of measles vaccine in order to establish possible pathways for the non targeted effects of standard titre measles immunization.Expected Outcome* Vaccine efficacy: vaccine efficacy will be assessed both as cumulative incidence from the time of entering the study at six months of age and as protection rate following exposure from a measles case in the same house.* Measles antibodies: measles antibody responses as well as decay in measles antibodies levels will be analysed for a subgroup of individuals. Since previous studies have shown that antibody titre below 125 miU are not protective, children with such low titres at 18 months of age will be offered reimmunization.* Mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chondral and osseous tissue engineering' (1998-2002).

assistant: **Concept**

We will develop innovative therapeutic products and methods for the treatment of degenerative joint cartilage damage and bone loss in ageing people, using the novel technology of tissue engineering. This involves novel co-culture of antilogous chondrocytes, stem cells or bone cells, and novel biodegradable scaffolds to construct new cartilage and bone. New microvascularised tissue transfer methods will also be used. The quality and characteristics of the developed cartilage and bone, and the healing process, will be evaluated using biochemistry, photochemistry, histology, radiology, etc. The clinical pilot study includes particular resurfacing in osteoarthritis, and bone regeneration in the treatment of large cranial bone defects and open tibia fractures, for the benefit of ageing people in Europe. It is a transactional, multidisciplinary project that will increase cornpetitiveness and employment in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ALgorithms for PAngenome Computational Analysis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Genomes are strings over the letters A,C,G,T, which represent nucleotides, the building blocks of DNA. In view of ultra-large amounts of genome sequence data emerging from ever more and technologically rapidly advancing genome sequencing devices—in the meantime, amounts of sequencing data accrued are reaching into the exabyte scale—the driving, urgent question is: how can we arrange and analyze these data masses in a formally rigorous, computationally efficient and biomedically rewarding manner?Graph based data structures have been pointed out to have disruptive benefits over traditional sequence based structures when representing pan-genomes, sufficiently large, evolutionarily coherent collections of genomes. This idea has its immediate justification in the laws of genetics: evolutionarily closely related genomes vary only in relatively little amounts of letters, while sharing the majority of their sequence content. Graph-based pan-genome representations that allow to remove redundancies without having to discard individual differences, make utmost sense. In this project, we will put this shift of paradigms—from sequence to graph based representations of genomes—into full effect. As a result, we can expect a wealth of practically relevant advantages, among which arrangement, analysis, compression, integration and exploitation of genome data are the most fundamental points. In addition, we will also open up a significant source of inspiration for computer science itself.For realizing our goals, our network will (i) decisively strengthen and form new ties in the emerging community of computational pan-genomics, (ii) perform research on all relevant frontiers, aiming at significant computational advances at the level of important breakthroughs, and (iii) boost relevant kn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'development of a tool for effective diagnostic monitoring of honey bee colonies.'.

assistant: **Innovation**

There are 600,000 beekeepers in the European sector, mainly SME family-owned companies. The revenue generated by this industry is more than €400M in Europe. However, the European Union has a net negative trade-balance in bee products, mainly honey, producing only 54% of its demand (the EU imports from cheaper producers, namely Argentina and China). However, despite its importance and the obvious potential for growth, serious problems face the sector. Bee populations and beekeepers numbers in Europe have been falling at an alarming rate. Honey imports to the EU have risen by 20% since 2001. Action to halt the decline in the European beekeeping sector is also urgently needed because bees also play a vital role in agricultural productivity. The role of bees as a pollinator remains the most important economic contribution, far outweighing the collective importance of all hive products. The economic value of pollination worldwide is estimated to be at least €153 billion, which represented 9.5% of the value of the world agricultural production used for human food in 2005. More than 70% of food crops and 35% of food production still depend on pollinators; 84% of vegetables grown in Europe depend on pollination.Our project will develop the first monitoring tool that would detect changes in honey bee activity within the beehive for the effective management of bees. Changes in the activity within the hive will indicate early signs of potential swarming and possible poor health, so the beekeeper can intervene to manage the colony. The tool will allow beekeepers to remotely diagnose colony status without the invasive opening of hives for physical inspection.This will increase the efficiency of beekeeping allowing small and hobby beekeepers to more closely manage their colonies and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Challenges in Competitive Online Optimisation' to be submitted under Horizon Europe.

assistant: **Abstract**

Online decision-making, characterized by the need to make decisions without knowledge of the future, lies at the heart of numerous applications. Despite its prevalence, our grasp of effective strategies for handling the associated uncertainty remains poor. Through the lens of the established framework of online algorithms as well as the emerging field of learning-augmented algorithms, this project aims to address central challenges in decision making under uncertainty.While there has been extensive research on online algorithms, many of the field's core challenges remain unresolved. However, several recent discoveries of new algorithmic design and analysis techniques have opened up novel avenues for overcoming previous obstacles.Alongside these technical advancements, the rise of machine learning is now significantly enriching our toolset for dealing with uncertainty. This has motivated the recent emergence of the field of learning-augmented algorithms. Here, an algorithm's input is augmented with predictions, aiming for near-optimal performance if predictions are reasonably good, while still retaining classical worst-case guarantees even for highly erroneous predictions.Inspired by these recent developments, this project aims to substantially elevate our understanding of decision-making under uncertainty. The main objectives are (1) to explore new directions around the concept of work functions, (2) to elevate the mirror descent technique into a generic tool for online algorithm design, (3) to develop universal techniques for designing learning-augmented algorithms, and (4) to expand the scope of learning-augmented algorithms to new domains.The project addresses questions at the forefront of theoretical computer science, building on the PI's recent success in resolving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Credit and real activity - a disequilibrium dynamics perspective' (1994-1998) under Fourth Framework.

assistant: **Objectives**

In contrast with the usual view, the topic of my dissertation is strongly rooted in the idea that monetary factors and credit do affect the dynamics of economic systems through the process of production and investment financing In this context, these factors cannot be ruled out in the explanation of the emergence and persistence of macroeconomic real disequilibria which are unavoidable within the process of economic evolution. This view obviously contrasts with the traditional one which considers economic dynamics based on the assumption of medium or long run neutrality of money and credit. Moreover, our view might shed a different light on economic policy matters like, for example, credit creation regulation or distribution within the economic system. Therefore, our perspective will certainly draw the attention of readers on a more complex approach of economic policy including the question of Central Banks autonomy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Epigenetic profiling of breast cancer: prognostic and therapeutic applications' (DNA-METHYLATION).

assistant: **Concept**

Cancer is a genetic as well an epigenetic disease. A prominent epigenetic alteration is DNA-methylation in the promoter region of the gene that prevents the gene to be expressed. Recently high-throughput methods to analyze the methylation status of genes in a large number of samples simultaneously have been developed. Now, even global DNA-methylation can be studied using stable tumor DNA preparations, rather than the labile RNA preparations required for cDNA microarray analyses. This way, new target genes, which provide the basis to improve treatment strategies, can be discovered. With the aim to catch up with the current genomic information and to implement the epigenetic DNA-methylation analyses in the clinical setting, we formed the present consortium encompassing members of the European Union and associated member states to take a multidisciplinary and innovative approach to study DNA-methylation of breast tumors in order to improve prognosis and treatment possibilities of the patients. The participating centers contribute complementary state-of-the-art proprietary technical expertise, large and well-documented tissue resources, and intense clinical expertise. Recently, members of this consortium have developed epigenetic predictive signatures for breast cancer patients treated with endocrine therapy. This proof-of-principle is the basis for the breast cancer studies proposed in the present project and the main objectives are: 1) By genome-wide DNA-methylation screening identify new therapeutic targets. 2) Develop prognostic and predictive DNA-methylation markers. 3) Confirm these findings at the mRNA and protein level, and in clinically relevant subgroups of breast cancer. 4) Commercialize relevant target genes discovered for prognostic, predictive and therapeutic