RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Prostate Cancer DIagnOsis and TreatmeNt Enhancement through the Power of Big Data in EuRope'.

assistant: **Innovation**

Prostate Cancer (PCa) is the second leading cause of cancer, among men in Europe. There are currently major unmet needs in this field, such as insufficient knowledge on risk factors that contribute to PCa and on patient characteristics (including genetic profiles) that could facilitate patient stratification. Finally, there is lack of meaningful engagement of all key stakeholders, while the knowledge currently gained from clinical practice and real life data is not being fed back into PCa patients’ care pathways. There is thus a need for better definition of PCa across all stages, improved patient’s stratification at diagnosis, and standardisation of PCa-related outcomes based on real life data.PIONEER’s unique dual approach is to first identify critical evidence gaps in PCa by respected Key Opinion Leaders, and then embark on a research priority setting exercise that reflects the needs of all key stakeholders in  PCa management. To achieve this, PIONEER has brought together comprehensive datasets that consists of the most relevant prostate clinical trials and registries, large epidemiological cohorts, electronic heath records, and real-life data from different European (and non-European) patient populations. These unique data sets will be integrated, standardised, harmonised and analysed using approaches that are built on our experience of similar previous IMI projects i.e EMIF, and eTRIKS, and analysed using a unique set of methodologies and advanced analytics methods (OMOP, eHS).  PIONEER has already performed a first PCa research priority setting survey, where major stakeholders were asked to identify the current unmet needs in PCa. The five most important open questions will be used as pilot studies to verify PIONEER’s research framework.  As such, PIONEER’s delive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The arterial adventitia: a critical actor in atherosclerotic plaque progression and stability?' (ADVENTITIA) under Seventh Framework.

assistant: **Objectives**

Background: The clinical outcome of cardiovascular diseases such as myocardial infarction and stroke is generally caused by rupture or erosion of an atherosclerotic plaque. While the contribution of the plaque intima and media to plaque initiation and progression are well acknowledged, that of the arterial perivascular tissue, the adventitia, is not established yet.  Hypothesis: Adventitial inflammation, which is partially modulated by adipocyte activity, profoundly impacts plaque progression and stability and that modulation of this process could be a new therapeutic approach to improve the resilience of a plaque to rupture. Key objectives: 1) Determine the contribution of adventitial activation of adipocytes to plaque progression and stability in vivo in our model of collar aided carotid artery atherosclerosis, which affords flow induced atherosclerotic lesions, accessible to local intervention. Specific adipocyte activators will be applied, either systemically or focally and its effect on plaque development tested. Likewise, the effect of specific inhibitors of adipocytes activation will be determined. 2) Assess the possible activation pathways in situ and the culprit actors responsible for the plaque destabilizing effect. Implications: The results of these studies will not only increase our insight in the pivotal role of the adventitia in atherosclerotic plaque development and stability, but also is expected to lead to new targets and therapeutic modalities in the treatment of cardiovascular diseases. The applicant finished her Ph.D. summa cum laude at the CSIC (Spanish Research Council) in Seville and is currently Post-doctoral fellow. The mutual intentions of creating a long-term collaboration between the two institutes furthermore contributes to the impact the fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Attosecond dynamics in molecular systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Ultrafast processes in molecules with key character for the macroscopic properties of matter have been studied so far utilizing the best available tools for gaining temporal resolution, namely: femtosecond laser pulses. These pulses however, though capable of providing resolution to track the atomic motion and the formation and rupture of the chemical bond in real time, fail to track the motion of electrons which  is expected to evolve on an attosecond time scale ( 1 as =10^-18 s).  The project aims to employ for the first time attosecond technology in order to track and control electron dynamics in molecules opening the door to a new era of applications on a microscopic scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Inhibition of stress activated protein kinase signalling as a therapeutic strategy against excitotoxicity' in the context of a Sixth Framework call.

assistant: **Objectives**

Excitotoxicity (EXC), neuronal death from excessive stimulation, contributes to a plethora of neurodegenerative conditions including cerebral ischemia and seizure-induced death. Stress activated protein kinases (SAPKs) of the JNK and p38 families have been identified as novel mediators of EXC death which is mainly executed by existing proteins demanding post-translational modifications. STRESSPROTECT members have (a) demonstrated that specific TAT-fused peptide inhibitors of the JNK pathway confer lasting neuroprotection against seizure induced and ischemic cell death with an extended therapeutic window, (b) analysed the individual apoptotic actions of SAPK isoforms, and (c) provided important insights into signalling from glutamate-receptors. STRESSPROTECT gathers the European elite for SAPK signalling in the brain and for neuroprotection against EXC by pharmacological intervention in these pathways, and proposes a novel therapeutic concept against EXC. STRESSPROTECT provides synergistic research activities addressing the organisation and function of SAPKs signalling with molecular genetics, proteomics, signalosome-analysis, and molecular pharmacology including pharmacokinetics. At the end STRESSPROTECT has identified EXC-related SAPK signalosomes and delivered novel inhibitor peptides against SAPK sig-nalling underlying EXC-mediated degeneration. STRESSPROTECT will identify (a) proteins in upstream regulatory complexes induced by EXC, (b) the downstream targets mediating EXC and (c) specific protein-protein interaction sequences as targets for functional inhibition of SAPK signalling; STRESSPROTECT (d) extend the neuroprotective value of existing inhibitory peptides, (e) develop novel TAT-fused peptides inhibiting particular loci in the stress kinase pathways, (f) dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CONductive fast Charge system for Electric buses in Public Transport' (CONCEPT).

assistant: **Innovation**

Heliox, a company specialized in switch mode power technology, is developing a Conductive Fast Charge System for buseswhich will offer a cost-effective breakthrough technology for zero emission public transport AND competitive strength to theEuropean Bus manufacturing industry. The objective of this business innovation propoject have been defined to reach theoverall goal: to succesful launch the Conductive Fast Charge System for buses. Heliox' Conductive Fast Charge system isdesigned for opportunity charging at e.g. end of bus line, extending the range of an (H)EV. A minimal onboard energystorage, enough to reach the next charging station, becomes practically sufficient to optimally operate a vehicle with lowTCO and high availability. Potential users are: public transport operators and European bus manufacturers. Based onrigourus studies and feasibility assessments, conducted under the SME Phase 1 project (number 650507), Heliox developeda solid business plan that incorporates a commercialization strategy and a financing plan to underpin the forseeen marketlaunch and growth strategy of the system.The Company has already piloted its Product Generation 1 in a real environment and has established strong relationshipswith several Northern European city bus services and continues to initiate relationships with potential customers publictransport operators and European bus manufacturers.Product readiness: The Product Generation 1 is between TRL 7 and TRL 8 with 8 units sold and 15 more in the pipeline tobe sold for piloting purposes. Generation 2 is at TRL 6 and moving towards TRL 7. The Company is currently improving theproduct’s value and profit propositions based on its end-customers feedback (urban transport authorities and municipalities)and immediate customers such as b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ecological and Evolutionary consequences of predator-prey phenological match-mismatch driven by climate change' (EcoEvoClim).

assistant: **Concept**

Global Climate Change (CC) is affecting the phenotype, abundance, and distribution of animal and plant populations as well as their interactions, e.g. phenological shifts affecting predator-prey time match-mismatch. Understanding how organisms cope with change is a fundamental objective of biologists. Scientists are now increasingly aware that ecological and evolutionary change in response to CC can occur concurrently, while their interaction can affect populations in a process called eco-evolutionary dynamics. However, we know little about the role of genetic and correlated traits variation and their relations to plasticity in the ability of organisms to cope with CC. The main goal of EcoEvoClim is to assess the role of genetic variation and plasticity in the eco-evolutionary response to CC of (mis)timed predator populations with a genetically determined colour polymorphism that covaries with behavioural traits. To this aim, I will use observational and theoretical approaches, by combining state-of-the art technology (fine-resolution GPS telemetry and bird migration radar), long-term field datasets, and latest population modelling tools (Integral Projection Models). This challenging goal will be achieved by joining a research group where world renowned experts at the forefront of developing and applying these techniques and concepts proposed here will collaborate to develop this project. EcoEvoClim, at the interface of behavioural ecology and evolutionary biology, will follow a multidisciplinary approach, synthetizing concepts from the fields of movement ecology, meteorology, remote sensing, genetics and population dynamics. The Fellowship will provide me with a unique opportunity to deepen my knowledge on eco-evolutionary research, as well as expertise in the use of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'KAMINLER – KAM and Innovation services for SMEs in Lombardia and Emilia Romagna' under Horizon 2020.

assistant: **Concept**

The objective of the proposal is to provide a new Enterprise Europe Network service to enhance the innovation management capacity of SMEs in Lombardy and in Emilia-Romagna.EEN partners in the two regions will deliver  Key Account Mangement services to the beneficiaries of the SME Instrument of Horizon 2020 and will support particularly promising SMEs to improve their capacity to manage innovation processes.Therefore the new service will be provided to two target groups of companies:- Beneficiaries of the SME Instrument- SMEs with significant innovation activities and a high potential for internationalisationThe new service will be incorporated into basic EEN services starting from 01/01/2015 and possibly further extended with the support of other partners of the future consortium.


**Keywords:** Innovation, SME Instrument, internationalization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self installing wind turbine' to be submitted under Sixth Framework.

assistant: **Abstract**

Participants plan to demonstrate to the offshore wind industry the realisation of a novel offshore wind turbine concept using a suction pile foundation. The subject concept allows installation of the complete wind turbine, substructure and suction pile foundation offshore in one piece. The concept is virtually independent of the water depth as floating equipment is utilised. This allows offshore wind parks to be installed in deeper waters out of sight from the coastline.The marine spread required comprises a flat top barge, tugs, lowering system and suction pumps. These items are relatively cheap and widely available. In port the complete substructure with suction piles, tower and turbine will be erected and constructed as one unit. The complete unit will be supported on the end or corner of the barge and hung-off using a special frame. The unit will seafastened to the barge and is then ready for sailaway to the offshore location.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Large Area organic devices with Bar-assisted meniscus shearing technology' (LAB-TECH).

assistant: **Innovation**

Organic-based devices have recently emerged in the market beginning to replace amorphous silicon in some applications, and also with great perspectives to find their place in a wide range of new applications that require low cost, flexibility and large area coverage. However, high and long-term performing organic semiconductors compatible with cheap solution-processed techniques are scare and thus, the achievement of processability and stability in organic devices is still a current challenge that must be overcome.Researchers from the ERC project e-GAMES, following one of its milestones towards the final fabrication of organic devices for sensing applications in water, have successfully developed a novel organic semiconductor deposition technique, namely Bar-Assisted Meniscus Shearing (BAMS), that leads to materials with unique properties for the fabrication of highly performing organic field-effect transistors (OFETs).Under the framework of LAB-TECH, the potential exploitation of this innovative technology by means of the technological validation of the up-scaling process of BAMS will be analysed. Additionally, an in depth study of the different market niches, financial needs, and stakeholders required for its commercialization will be taken into account on a dedicated business plan.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European coordination action on human biomonitoring' under Seventh Framework.

assistant: **Concept**

This proposal has been elaborated by a consortium of 35 partners coming from 27 European countries and including scientists, government institutions and authorities, NGOs and industry. The main goal is to develop a coherent approach to HBM in Europe as requested by ACTION 3 of the EU Environment and Health Action Plan through coordination of ongoing and planned HBM activities. The project will exploit existing and planned HBM projects and programmes of work and capabilities in Europe. The consortium will investigate what is needed to advance and improve comparability of HBM data across Europe. Work prepared under DG Research and DG Environment activities dealing with development, validation and use of novel biomarkers including non-invasive markers and effect markers will be exploited. Through close collaboration with similar initiatives in the field of Health - such as the EU Health Examination Survey - appropriate economies and efficiencies will be assessed. Key issues such as Ethics and human Biobanks will be addressed. The project will deliver a number of key outputs including: 1. Tested Proofs of Concept and/or Demonstration project assessing the feasibility of a coordinated approach, including strategies for data interpretation & integration with environmental and health data. 2. A rationale and strategy for communication and dissemination of information, results and key messages to all stakeholders from the public to policy makers 3. Training and capacity building will aim to promote knowledge and experience exchange and development in the field of HBM within Europe A common understanding within all parties involved on the potential of HMB in supporting and evaluating current/future policy making (including e.g. REACH) and for environmental health awareness raisi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SEWAGE SLUDGE WITH ENERGY RECOVERY THROUGH DOWNSCALED FLUIDISED BED GASIFICATION AND CHP UNITS' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

DESCRIPTION OF WORKThe ETVS - Process allows to process liquid and pasty waste such as sewage sludge and solid biomass such as wood waste and to utilize the product-gas for Power-Generation and ash as raw material direct on site.The following illustrates the Process when treating sewage sludge with the ETVS: The sewage sludge (2% solids) will first be dewatered to highest possible dry substance contents. The produced filter cake will be dried to high solid contents in a low temperature Dryer (FBD). The dried and pelletized sludge will thereafter be converted into low-BTU gas by gasification in an air blown, atmospheric Fluidized Bed Gasifier (FBG). The electric power generated from the cleaned low-BTU gas will meet the internal load demand of the wastewater treatment plant. Heat recovered from gasification and power generation is used for the drying process. This process which can be entirely self-sustaining as to the overall energy balance when gasifying raw sludge with more than 30% solids can help to solve the sludge disposal problem being caused by the new regulation coming into effect in 2005.The building- and maintenance-costs can be very low by combining the ETVS-process with advanced biological waste water treatment processes. Construction and operating cost of waste water treatment plants can substantially be reduced by integrating the ETVS - Process into the biological treatment units of advanced waste water treatment plants.In conventional thermal treatment disposal has the priority. Cost and energy balance appears to be of minor importance for these treatment options.The cost of sludge disposal is mainly determined by the process applied.With the energetic synergy effects of the ETVS-process through heat recovery the maximum possible synergies will be achiev