RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Screening and development of optimized materials for high temperature coils' (HTcoils).

assistant: **Concept**

Electrical Environmental Control Systems (E-ECS) feature many low power electromechanical actuators to ensure control and tuning of items such as valves. They also include motorized turbomachines with power electrical motors.In both cases, the temperature class of coils integrated in motors or electromechanical actuators must be increased to minimize requested cooling and thus optimize both integration and mass of the system.So, these high temperature coils can be: A winding of electromagnet, a winding of a torque motor, a winding of a power electrical motor.The main objectives of this topic are:- to develop specific wires, impregnating varnishes and potting ingredients (resins) to have complete solutions for high temperature coil and qualify these ingredients,-  to manufacture high temperature coils with these ingredients, integrate them in the Topic Manager’s defined application and demonstrate that the solutions proposed can be industrialized.The solutions shall comply with aeronautical constraints (electrical, vibration, lifetime, manufacturing process, etc.) and sustain a minimal temperature of 300°C. The main objectives of this topic are to develop specific wires, impregnating varnishes and potting ingredients (resins) to have complete solutions for high temperature coil and qualify these ingredients, to manufacture high temperature coils with these ingredients, integrate them in the Topic Manager’s defined application and demonstrate that the solutions proposed can be industrialized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing an understanding of trace gas fluxes over complex surfaces', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The Marie Curie Fellows will add know how in atmospheric chemistry and measurement of trace gases, analysis of turbulence data with new methodology and understanding of transport processes over complex heterogeneous rough surfaces. Major benefits are:(i) the development and application of a footprint mode,(ii) the existing capability to continuously monitor water and carbon fluxes between vegetation and the atmosphere will be enlarged to other species like N, VOC and Ozone, and(iii) the validation of the footprint model by atmospheric tracers.This will multiply the value of the existing flux measurements over forests; allow a better judgement of observed carbon sinks and their relevance to the European Union. It will transfer technology in the extremely relevant field of trace gas flux monitoring and enlarged the hosting institution's competence in land surface processes, its ability to attract national funding and to train environmental scientists in the important area of trace gases and climatic forcing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'WELCOME - Wearable Sensing and Smart Cloud Computing for Integrated Care to COPD Patients with Co-morbidities' (WELCOME) under Seventh Framework.

assistant: **Objectives**

WELCOME is an ambitious project aiming to develop an integrated care approach for continuous monitoring, early diagnosis and detection of worsening events and treatment of patients suffering from Chronic Obstructive Pulmonary Disease (COPD) with comorbidities Chronic Heart Failure, Diabetes, Anxiety and Depression.<br/>The WELCOME solution for the patient will be based on:1. An adjustable, wearable and washable vest providing continuous monitoring of a large number of sensors each one measuring various physiological signals, like chest sounds, pleural effusion, tachycardia or arrhythmia, atrial fibrillation etc,. The vest will be comfortable, inconspicuous, and easy to put on by the patient, it will require simple maintenance (simultaneous sensor recharging, normal washing procedure) and can be modified according to each patient's individual needs.2. Wearable sensors for measuring blood trends like glucose, cholesterols, triglycerides, potassium, serum creatinine, blood pressure etc in a periodic basis.3. Inhaler devices for measuring and evaluating the medical adherence of the patients.<br/>Remote, continuous monitoring and analysis of patient multi-parametric data, such as physiological, environmental, emotional and genetic data, will be used for designing the personalized integrated care programs ranging from self-care guidance and regulation (e.g e-coaching) at home and outdoors to professional primary and secondary health-care support (e.g including telemonitoring and remote support or comprehensive expert support at the clinic). The process will be facilitated by a cloud based Decision Support System, providing statistical/intelligent analysis of the therapy policies and patient conditions enhanced by multiple patients' data fusion and discovery of patterns on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Outcomes Assessment of Sensory Education in Schools'.

assistant: **Objectives**

This action addresses EU SC1: Health, demographic change and wellbeing. Diet related ill health is a major threat to public health and the sustainability of health services in the UK, Europe and internationally. Sensory education has been proposed as one aspect of a multi-pronged response strategy. It aims to improve children’s confidence and enjoyment in trying and appreciating flavours, so as to support the development of healthy dietary variety. Sensory education has been embedded in schools and nurseries in other countries (e.g. Sweden, Finland), but not in UK schools. This action will develop new methods for assessing outcomes of sensory education, and conduct outcomes assessment of the novel Flavour School intervention programme in UK schools. Flavour School is a sensory education programme adapting the established Sapere method to the UK school context. It currently targets early primary school children, age 4-5 years, with particular focus on fruit and vegetables. Outcomes assessment of sensory education has proven challenging. This action will develop new methods for assessment, following recommendations emerging from previous research for direct behavioural analysis in more natural settings, and video recorded testing sessions to enable more sophisticated analysis. These methods are labour intensive, so this action will also develop computer vision facial expression analysis to facilitate video coding, to enable larger scale studies with economically feasible human labour levels. Overall, this action will assess the value of a specific programme of sensory education in UK schools, and will develop innovative, open-source methods for outcomes assessment which will be valuable for gathering quantitative data on the impact of sensory education more generally. In
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chips for Life' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Respiratory tract infections (RTIs) are a huge burden in terms of mortality and morbidity worldwide. To improve the management of the bacterial infections of the respiratory tract, the institution of an appropriate antimicrobial therapy as soon as possible has also been shown to be a key element for reducing morbidity and mortality. The aim of our project is to develop a panel of dedicated rapid diagnostic tests to allow the medical staff to link antibiotic prescription on evidence-based diagnosis. In our 3 year project, combining the Multiplex Ligation-dependent Probe Amplification (MLPA) and microfluidic technologies will allow to address the question of viral or bacterial origin. In the case of a bacteria, a second step will allow to identify which bacteria is of interest with its virulence factors and resistance mechanisms. This new tool will be developed for efficient use in clinical settings in order to allow for a better antibiotic resistance management.  Several direct impacts will be observed either on public health (decrease of antibiotic pressure), efficiency of treatment for patients (decrease of infectivity and speed in accurate treatments), for diagnostic laboratories (improve in turn around time), for SMEs (better competitiveness) and more generaly on technological innovations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'The gdnfr-alpha receptor gene family and its role in mammalian embryogenesis'.

assistant: **Objectives**

Research objectives and content Glial cell line-derived neurotrophic factor (GDNF) and Neurturin are two members of a growth factor family with potent neurotrophic activity for a wide range of neurons for the peripheral and central nervous system. Recently, it has been suggested that GDNFR-a, (a GPI-linked cell surface protein) and the Ret receptor tyrosine kinase (RTK), are two key components of the GDNF receptor complex. However, nothing is known about the receptor and signalling mechanism of Neurturin. We have identified two novel genes (called GDNFR-5 and GDNFR-Y) which appear to encode members of the GDNFR family of GPI- linked receptors. In this proposal, we wish to investigate the signalling specificity of GDNF and Neurturin in relation to the GDNFR molecules and the Ret RTK using Xenopus embryo and oocyte assays. In addition, in order to get insight into the in vivo function of the GDNFR-5 and GDNFR-y, genes, targeted inactivation experiments will be performed in mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids in blood'.

assistant: **Innovation**

Blood-based biomarkers such as Circulating Tumor Cells (CTCs), circulating free tumor DNA (cfDNA) and microRNAs (miRNAs) have the potential to improve the development of personalized medicines for cancer patients. This is of particular importance when biopsies of the primary tumor or metastases are not accessible (e.g. at early disease stages or in minimal residual disease) or possible and the associated risk of adverse events when taking a biopsy is high. Furthermore, a longitudinal follow-up of disease markers is desirable to improve prognosis or to monitor treatment efficacy. CANCER-ID aims to validate technologies for CTCs, cfDNA and miRNAs to determine the absence/presence of drug targets and assess the response to treatment. Important challenges for all circulating biomarker development are assay sensitivity, specificity and assay standardization and validation. In three project phases (pre-evaluation, technical assay validation and clinical validation) the CANCER-ID consortium aims at the development and validation of Standard Operating Procedures (SOPs) for technologies assessing blood-based biomarkers. In the pre-evaluation phase, four working groups will be established that will evaluate biomarker technologies and set the criteria to be met for any technology before moving to the next phase. In the Technical Evaluation Phase, the technologies identified as promising in the pre-evaluation phase will be implemented and tested at the sites of the consortium members using blood samples taken from patients with metastatic carcinomas and healthy controls. In order to prove broader applicability and clinical utility of the consortium’s technologies and protocols, the validated assays will be deployed in controlled clinical studies (TRACERx, NVALT-17, SPECTAlung; pati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Revisiting the origin of intrinsic cellular autofluorescence in metabolic imaging' (ROICAM) under Horizon Europe.

assistant: **Objectives**

Metabolic dysregulation is a hallmark of numerous diseases. Multiphoton microscopy (MPM) combined with fluorescence lifetime imaging (FLIM) of the metabolic coenzymes NADH and FAD has emerged as a key method for monitoring metabolic processes in live tissue with sub-cellular resolution. However, recent data demonstrates that spectral crosstalk from other cellular components, such as keratin, is substantial. Yet the contributions from endogenous proteins are often neglected, bringing into question the validity of earlier studies. To address this issue, we propose to systematically scrutinize the fluorescence properties of NADH, FAD and keratin in different states and combinations. This will be done by meticulous investigation of the fluorescence lifetime, spectra and related photophysical properties using MPM and time-resolved spectrophotometry under a range of conditions (pH, temperature, viscosity, protein binding), and in combination with computational chemistry. Based on this knowledge, we will develop approaches that can accurately determine the concentration, diffusion and binding state of NADH and FAD even in the presence of spectral crosstalk from keratin. The strategy is to implement phasor-FLIM analysis, fluorescence lifetime correlation spectroscopy (FLCS) and raster lifetime image correlation spectroscopy (RLICS) to separate the fluorescence contributions of bound and unbound NADH and FAD from the protein background and quantify the spatial distribution of each species with unprecedented spatiotemporal resolution. The developed methodologies will be validated by monitoring cellular metabolism in human primary cells and tumour cell lines. This study will solidify our understanding of NADH and FAD autofluorescence in complex cellular environments and substantia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cooperative Quantum Dynamics of Dipolar Ensembles' (COQUDDE).

assistant: **Concept**

A new cooperative regime of matter-light interactions opened up recently in research of advanced optical technologies. Optical response of strongly interacting dipolar emitters is important in systems ranging from naturally occurring photosynthesis complexes and dye molecule aggregates, to metamaterials in new solar cell and atomic clock designs. Cooperative regime offers potential for strong, collectively enhanced single-photon coupling and nonlinearities, promising new platforms for optical control at a single photon level, precision measurements and quantum simulations. However there is yet no existing methodology for understanding optical response of this complex, many-body systems.Recent progress in control of cold atom ensembles on length scales shorter than the wavelength of the field mediating interaction promises new simple and controllable platform to explore cooperative regime. This action will use unique combination of two complementary cold atom experiments in this regime. The first one achieves small, dense atomic samples; the second provides direct control and measurement of positions and states of individual atoms, together with real-time control of their external and internal degrees of freedom.The applicant will extend this two experiments to explore new control schemes and access new observables. These will be used in benchmarking of knowledge about the cooperative regime, guiding development of new theoretical methods. Applicant’s combination of experimental and theoretical experience in analysis of complex atom-light interactions will be used for high performance computing numerical simulations. During secondment this will be distilled into effective models relaying on new theoretical methodology. Through combined theoretical and experimental work,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A collaborative analysis of public health and health service issues in ruralareas to identify common needs and priorities', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives:- To review and report on the existing base of scientific knowledge of public health and health service issues in rural areas.- To identify gaps in current knowledge and understanding. - To identify priorities for future research as a basis for the development of a programme of pan-European research and to develop an agenda for action on other identified priorities.Brief description:Approximately 20 per cent of Europe's inhabitants live in what can be termed rural areas. There are many issues surrounding morbidity, access to health care services and equity in these areas. The problem of isolation - for both the populations of rural areas and practising health professionals - is very real. Discussion and initial research to date has indicated that certain issues and problems may be common across Member States. The overall aim of the project is to undertake a collaborative study of public health and health service issues in rural areas. It will inform the development of pan-European action to tackle common needs and priorities.Keywords:Public health, Health services, Rural Health needs, Health promotion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Potential Oxygen Limitation of Distributions And Responses to Changing Climates In Ectotherms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Climate change is driving many species to migrate along the altitudinal gradient of mountainous landscapes. While the impacts of temperature shifts on range expansion are well established, the effects of altitude-related hypoxia on the ability of organisms to colonize and adapt to higher altitudes during warming have, to our knowledge, not received scientific interest. Specifically, the short, medium and long term effects of acute and chronic hypoxia on the growth, survival, reproductive biology and colonization dynamics of animals reaching higher altitude refuges remain unknown. PODARCIS will generate such knowledge, via a detailed study of physiological responses to hypoxia across an altitudinal gradient in a species that undergoes upward range expansion, the wall lizard Podarcis muralis. PODARCIS will (1) assess multivariate acclimation responses in embryos and adult lizards from low to high altitude using common garden and reciprocal transplant experiments (i.e. to assess the effectiveness for plastic responses to enable colonization and detect changes in the degree of plasticity across the altitudinal gradient) and (2) predict the dynamics of colonization by integrating data on physiological plasticity, reproductive output and dispersal. Taken together, this project will combine hard-to-obtain empirical data with theoretical modeling approaches to provide valuable insights into the ecological and evolutionary processes that determine a species' response to climate change. PODARCIS requires a multidisciplinary approach, drawing from the fields of physiology, quantitative genetics, evolutionary theory, and computer modeling. The synergistic skill sets brought to this project by the fellow and the mentor scientist will allow an important cross-continental exchange of