RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Global Estimates for non-linear stochastic PDEs' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The project is concerned with the global behaviour of solutions to  Stochastic Partial Differential Equations  (SPDEs)  from Mathematical Physics which arise e.g. in the description of scaling limits of interacting particle systems and in the  analysis of Quantum Field Theories. The equations contain noise terms which describe random fluctuations and act on all length scales. In this situation  the presence of a non-linear term can  lead to divergencies.  A subtle renormalisation procedure, which amounts to  removing   infinite terms, is needed.   Over the last years the understanding of non-linear SPDEs has been revolutionised and  a systematic treatment of  the renormalisation procedure has been achieved.  This led to a short-time well-posedness theory on compact domains for a large class of highly relevant semi-linear SPDEs.   In this project, I will describe  the global - both in time and over infinite domains - behaviour of solutions of some of the most prominent examples, by combining PDE techniques for the non-linear equations without  noise and  the improved understanding of the subtle small-scale stochastic cancellations.   I have already pioneered  such a programme in an important special case, the dynamic Phi-4 model.  The project has three specific  strands:   A)  Proving estimates for the stochastic quantisation equations of the Sine-Gordon and Liouville Quantum  Gravity models and eventually Gauge theories, and to giving a PDE-based approach to the celebrated 1-2-3 scaling  of the KPZ equation,  B) giving PDE-based constructions of  Phi-4 models in fractional dimension and  describing phase transitions in terms  of mixing properties of the  dynamics,  C) treating degenerate parabolic equations and exploring if systems that fail to satisfy a fundamental ""s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Molecular Maturation Mechanism of HIV-1 Protease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Over the last decade of AIDS therapy, the HIV-1 protease has emerged as one of the key targets of anti-retroviral inhibitors, owing to its key role in the life-cycle of the virus. The protease cleaves viral polyprotein chains resulting in virion maturation and infectivity. The first stage of this process is the association of such chains containing embedded pseudo-folded protease monomers, followed by the intramolecular autocatalytic cleavage of the protease out of the polyprotein chains. Whilst, the structure, dynamics and function of mature/free HIV-1 protease have been extensively studied at the atomistic level, the molecular structure and binding mechanism of the embedded autocatalytic protease are unknown. Using large scale fully atomistic molecular dynamics simulations on the microsecond timescale, afforded by the computational infrastructure of GPUGrid, the transient structure, dynamics and auto-binding mechanism of embedded HIV-1 protease will be investigated. The aim of these investigations is to distinguish at a molecular level (a) the gating mechanism of mature HIV-1 protease in response to ligands (b) the gating mechanism of intramolecular N-terminal association of the embedded HIV-1 protease and (c) the feasibility of intramolecular C-terminal cleavage by the protease. The release of mature HIV-1 protease is a critical rate-limiting step in the maturation of the virus. Successful inhibition of this stage of the viral life-cycle may lead to a potent increase in the efficacy of AIDS therapy. Unfortunately, structure-based inhibitors designed for the mature/free protease are ineffective against the embedded-protease. A final aim of this investigation will thus be to identify an ensemble of macromolecular structures that could be used as pharmacophores in the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European School of Neuroimmunology (EFNI); 4th Teaching Course - Barcelona' (EFNI), addressing dissemination and exploitation.

assistant: **Impact**

European School of Neuroimmunology (ESNI) represents a European frame work for a continuous educational programme in neuroimmunology. A major aim is to integrate post-genomics research including research on molecular mechanisms into more established neuroimmunological approaches. Another major aim is to link this basic and post-genomic research to causes, clinical manifestations, consequences and treatment of disease in the brain and the nervous system. The main factor in the educational programme is the yearly course covering all these aspects. Previous courses (Stockholm 2000, Paris 2001, Tampere 2002) have attracted approximately. 200 participants to each course. One half of participants have been doctors linked to clinical activity and one half has been scientists working in basic medicine. Average age for participants has been 30 years and there has been an equal number of males and females. The ESNI Scientific Board contains members from 17 European countries, 9 of them with female representation. The 4th ESNI course will take place Sept. 28th - Oct. 2st 2003 at the University Hospital, Barcelona. The main topics will be innate immunity and brain functions, neurodegeneration and immunoregulation, relevance of autoantibody research in neuroimmunology, and immunothérapies in neuroimmunology. The programme covers genetics and post-genetic topics, as well as treatment applications. Discussion groups between a few participants and a senior speaker will be organised. Proceedings from the course will be available for all participants. The aim is to attract about 200 promising young researchers in neuroscience from most European countries. Top European researchers have already been scheduled as speakers. The main expenses will be travel and lodging for speakers, chairmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordination Action of the European Network of Territorial Intelligence' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of the CAENTI, Coordination Action of the European Network of Territorial Intelligence, is to integrate current research activities on tools of territorial intelligence so as to provide them with a European dimension. The CAENTI aims to promote comparative research to conceive and spread tools, methodologies and research protocols accessible to the researchers in the social sciences and to the actors of sustainable development of territories. It will constitute applicable data sets for multi-field research and for territorial development.The EU introduced several years ago the need for project management and evaluation. Since Goteborg, sustainable development rules have established the principles of good governance: participation, well-balanced approach and partnership. Scientific methods adapted to these principles are available to the experts, but the territorial actors rarely benefit from simple and cheap tools to elaborate, manage, observe, evaluate and transfer their projects. Such instruments mobilise fundamental research activities - provider of quality guarantee - as well as territorial actors to experiment and evaluate them. The CAENTI consortium will organise a rigorous management of its coordination activities. An annual international conference and an Internet gateway will also facilitate dissemination.Three comparative research activities will be implemented:I). The spreading of fundamental methods and research design in territorial information analysis within the social sciences and humanitiesII). Analysis of the application of the principles of governance of the sustainable development in the territorial research-actionIII). Design and dissemination of methods and tools of territorial intelligence accessible to the territorial actors and res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Solar cells from metallurgical silicon feedstock'.

assistant: **Innovation**

SUMMARY Silicon solar cells are not economically competitive when compared with other energy sources due to the expensive solar grade silicon material. The main objective of the SCARF project is to provide a thin filmsilicon solar cell on a cheap silicon substrate by means of the Liquid Phase Epitaxy (LPE) technique. The project co-ordinator Elkem/Norway is the world's lading supplier of silicon metal (MG-Si) to the chemical and the electronic industries. The company will take on the task to engineer and produce an upgraded low-cost metallurgical silicon. This material will then be cast/crystallized by three of the project partners: * Eurosolare/Italy will use the Bridgman crystallizer. * Institute for Crystal Growth (IKZ)/Germany will use the floating zone technique. * Fraunhofer Institute for Solar Energy Systems (Fraunhofer-ISE)/Germany will produce Silicon Sheet from Powder (SSP). The blocks/ingots will thereafter be cut into wafers by Eurosolare and IKZ. The silicon sheet will be provided with a surface texture at the University of Konstanz (UKN)/Germany. The partners IKZ and UKN will provide the wafers/SSP's with a thin film of silicon by two different LPE techniques. Fraunhofer-ISE, Eurosolare, and UKN will make solar cells from these thin films of silicon on the silicon substrater and Eurosolare will also make modules. Fraunhofer-ISE and UKN will characterize the solar cells. Finally, the Institute of Energy Technology (IFE)/Norway will asses the economic benefits of the solar cells developed by this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Programmable ARTificial immune systems to fight cancer' (ARTimmune).

assistant: **Concept**

Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function.  I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration.  Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. Whe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New Materials and their Dynamics - Advances through Synchrotron Radiation Spectroscopy' in the context of a Fifth Framework call.

assistant: **Objectives**

The development of advanced new materials and their engineering on nanoscopic length scales will be an important key-technology of the next century. The technological properties of these materials are not only determined by their structure but also by their electronic and vibrational dynamics. Examples of technological relevance are friction accompanied by phonon excitation, heat transfer in microelectronic devices and magnetoelastic effects in magnetic microstructures. The more the dynamical properties are expected to govern the function and performance of future devices, the more important are the efficient methods for their characterization. Synchrotron radiation (SR) has become an ideal tool in this field over the recent years. The ultra-high brilliance of third-generation SR sources initiated enormous progress in established X-ray methods and enabled the development of completely new types of spectroscopies for the study of condensed matter dynamics.A number of dedicated beamlines are available for inelastic scattering studies at SR facilities in Europe. So far, only very few research groups have used inelastic scattering methods in applications so that their strength is not common knowledge. The main objective of the EuroSchool is that potential users learn about the advantages of these novel techniques and that scientists from solid state physics, materials science, chemistry and biology join together in an multidisciplinary event and share their expertise. The EuroSchool will allow to bring SR specialists in contact with researchers that have detailed knowledge on advanced new materials and can rise the scientific questions to be worked on. The European scale of the event will enable the most efficient use of the inelastic research capabilities in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving the performance characteristics of peltron wheel flow meters' (1994-1998).

assistant: **Concept**

There are many types of liquid flow meters available for industrial measurement such as variable area (VA), ultrasonic electromagnetic and tracer (heat or particle) flow meters. However, meters, such as these, can be very expensive particularly non-intrusive remote types such as ultra sound flow meters), can be a safety hazard (e.g. glass VA meters) and can be restricted to small ranges of flow and very specific operating conditions (temperatures, pressures, viscosities, toxicity etc.). The Pehon wheel flow meter, on the other hand. has a high rangeability, it is small. relatively inexpensive. and can be constructed rom many materials (polymers. metals, ceramics etc.) so it can therefore be used in a range of corrosive and toxic. It can also be operated remotely, it is intrinsically safe and has a good speed of response. However, the associated pick-up coil and electronics are restricted to relatively small temperatures ranges (e.g. -30 to 135 degrees C). It would also be desirable to increase the maximum operating pressure (e.g. above 1000 bar) and it is also limited by the range of fluid viscosities with which it is able to measure. Litremeter Limited designs, specifies and manufactures Pelton wheel flow meters. It is the proposal of this project than using a detailed analysis of materials and electronics requirements and applying CFD modelling to gain an in-depth understanding of Pelton wheel fluid mechanics, it will be possible to greatly decrease the restrictions imposed by temperature and pressure and at the same time, increase the system's metrological performance. A summary of RTD objectives is given below: 1) To use CFD modelling to develop a less empirical understanding of Pelton wheel systems (i.e. clarify the inter-relationship of all perfomance and design v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Proof of Concept – Arctic Data Management System Beta version – capacity building for interpretation and data management system of the Arctic-related data and knowledge (Arctic Data Management System)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The specific objective is to design the Proof of Concept (PoC) - Arctic Data Management System (ADMS) Beta version - the first phase necessary for the implementation of the ADMS - a system of interpreting and managing Arctic-related data and knowledge. ADMS identifies and retrieves Arctic-related data and knowledge from multiple databases, adapts it to a common standard and provides interpretation, visualization and retrieval of the standardized data to an end-user. ADMS is based on state-of-the-art data intelligence tools including geographic information system (GIS), metadata catalogues, and interpretation and visualization tools. In the interpretation of data the system combines the highest level of technical and human elements to provide end-users with the highest quality and most appropriate data solutions. The Proof of Concept - ADMS Beta version - is a realization of a method to demonstrate the feasibility of the proposed data management system and to technically verify that the concept has the potential of being used by customers. By recruiting an Innovation Associate the Arctic Portal aims at demonstrating the feasibility of the proposed data management and interpretation system of the Arctic-related data and knowledge. The Innovation Associate will help the Arctic Portal to: (i) position itself as a hub for monitoring network’s Data Management System, Arctic interlinked data, analysis models and decision support tools; (ii) strengthen and improve the existing Global Terrestrial Network for Permafrost (GTN-P) Data Management System (DMS) located in Akureyri and designed by Arctic Portal; (iii) generalize and apply similar data management tools for other Global Monitoring Networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regulation of splicing by protein phosphorylation' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of our studies will be to elucidate the mechanism and role of reversible protein phosphorylation in the regulation of pre-mRNA splicing. Recently it was shown that protein dephosphorylation plays an important role in the pre-mRNA splicing process. Phosphorylation mechanisms can be regulated either through activities of protein kinases, which add phosphates, or via protein phosphatases which remove them, or both Since considerable evidence points for a role of protein phosphatases affecting pre-mRNA splicing, we propose to identify and characterise native forms of nuclear protein phosphatases acting on splicing factors. We will be using a newly developed affinity chromatography method in order to punfy and characterise native nuclear phosphatases acting on splicing factors.