RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Socially-acceptable Extended Reality Models and Systems'.

assistant: **Innovation**

The revolutionary opportunities opened by eXtended Reality (XR) technologies will only materialize if concepts, techniques, and tools are provisioned to ensure the social acceptance of XR systems. For that, we need XR systems that are not just innovative and functionally complex, but also provide an experience that: satisfies the goals and needs of the user, is in compliance with the social context in which the system is being used, and is transparent, safe, secure, explainable and is trusted by the user. However, current generations of XR systems fail to provide the XR experience they were envisioned for since state-of-the-art models and technologies of XR systems fail to ensure full-fledged social acceptance. A truly XR experience requires a major paradigm shift in the way XR systems are designed, implemented, deployed and consumed. The SERMAS project will develop innovative, formal and systematic methodologies and technologies to model, develop, analyze, test and user-study socially-acceptable XR systems. This will be achieved by pursuing the following four main objectives:   1. Follow an inter-disciplinary, multi-sectorial, case-study-driven, scientific and technological methodology to implement the SERMAS Toolkit, a set of methods and tools that will greatly simplify the design, development, deployment, and management of socially-acceptable XR systems.    2. Apply the Toolkit to industrial case studies drawn from real-world application scenarios, thus paving the way to transferring project results to industrial practice. This will be possible through the active participation in the consortium of the developers of mass-use industrial XR applications.   3. Enable innovators to leverage the Toolkit to improve the social acceptance and cut down the time-to-market of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Research your mind'.

assistant: **Innovation**

The project proposal Research Your Mind (RYM) will be a festive event in the frame of Researcher's Night 2006. It consists of organising a surprising and entertaining Researcher's Night based on a game which will take place on the 22 September 2006 in the different partners' selected cities; Barcelona (Spain) and Katowice (Poland).An awareness campaign will be addressed to attract the large public and especially young people, giving them the chance of getting closer to researchers and learn about research in an original, pleasant and attractive way. The RYM game will be an enjoyable pro-active competition to be played by participants with different profiles such as young people, scientists, politicians, journalists and businessmen, who will be divided into 3 teams.A master of ceremony will read the questions and each team will have approximately 3 minutes to discuss and answer each question. Based on 200 question cards, each card will contain a science-related question with multiple-choice answers (4 possible answers) with a humoristic character. The solution will be at the back of the card, including additional information and the link to an interesting web page, where applicable.The questions will be focused to improve public awareness of the importance of researcher's role in society and to increase the attractiveness of research career among students, covering the research areas of the 7th Framework Programme. The winner team will obtain invitations for museums, personalized tours to research laboratories and other activities related to science.The audience will receive a game set to play at home. Afterwards, a live band with musicians from the research community will play and drinks and snacks will be provided, bringing the researchers closer to the large public. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Immunogenetics of natural killer (NK) receptors' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Natural Killer (NK) cells are a subset of lymphocytes which display cytotoxicity against tumour and virally infected cells. This cytolytic activity is controlled by activating and inhibitory receptors. NK activating receptors include FcRgIII and NKR-PI. These belong to the immunoglobulin- (FcRgIII) or to the C-type lectin (NKR-P1) superfamilies and trigger NK cytotoxicity when bound to an immunoglobulin Fc or to a carbohydrate ligand on target cells, respectively. NK inhibitory receptors turn off NK cytotoxicity when engaged with an MHC class I molecule on a target cell. We will take advantage of the participants' expertise in the molecular biology of NK to achieve the following: First, we will perform molecular cloning of NK receptor genes from human chromosomes 19 and 12. This includes isolation of YAC and cosmid clones containing Ig-SF and C-type lectin NK receptor genes, molecular cloning of new genes and analysis of the genomic organization of the identified genes by long-range mapping. Secondly, we will perform functional characterization of new NK inhibitory receptors. We will establish a correlation between clonal expression of NK receptor genes and MHC specificity of NK cell clones. NK cell clones will be established from HLA-typed donors. The specificity of these clones will be determined by testing their cytotoxicity against a panel of MHC class I deletion mutants each transfected with distinct class I genes. NK clones with new MHC-related specificities will be analyzed for the expression of NK receptor genes by RT-PCR. We will perform transfection of NK receptor genes in NK cell clones. The correlation between clonal expression of new NK receptor genes and the MHC specificity of NK cell clones will be verified by transfecting the NK receptor genes into NK ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'SmartHeart, a 3D in vitro assay for improved assessment of cardiac drug efficacy and toxicity' (SmartHeart).

assistant: **Concept**

Currently, animal models are still widely used in the pre-clinical stage of drug development to mimic human diseases or predict the human body’s response to candidate drugs. However, their use should be minimized as much as possible due to ethical issues and since only 9.6% of drugs entering phase I of clinical trials end up being commercialized.  Therefore, the goal of this action is to develop a novel proprietary 3D in vitro cardiac assay.  The SmartHeart will retrieve several of the most important read-outs commonly assessed to study the impact of drugs at the cardiac level in the pre-clinical phase. The all in one assay will be based on a microstructured gel where cardiac cells, as cardiomyocytes derived from induced pluripotent stem cells will be cultured. The SmartHeart will answer to the shortcomings of academic and commercial available in vitro assays, by enabling the qualitative and quantitative measurement of several parameters, as contractility and Calcium transients. Simultaneously, the assay will enable sub-cellular structure observation via high-resolution imaging techniques. Furthermore, the 3D nature of the assay will contribute to the efficient maturation of the induced CMs, which is still a limiting factor when not using cardiac human cells, but rather induced CMs, in in vitro assays. The ultimate aim of the project is to make this device available to screening platforms, e.g. Pharma or CROs. The technology will be implemented in multiwell plates compatible with the standards of HTS/HCS and will be available to early-users, from whom feedback will be acquired, enabling to fine tune the specifications of the final device. This project will meet the best of the ER competences in physics, with the expertise of 4Dcell in 3Dcell culture systems. With this p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Next generation variety testing for improved cropping on European farmland' (InnoVar) under Horizon 2020.

assistant: **Objectives**

InnoVar will develop next generation plant variety testing by building tools and models that augment current practices capitalising on advances in genomics, phenomics, imaging technologies and machine learning. The InnoVar database, populated with historical and de novo genotypic, phenotypic and environmental data will facilitate model development and evaluation for revision of DUS and VCU processes. Innovative ways to measure DUS characters will be evaluated. VCU evaluation procedures will be revised and shaped to comprehensively address variability in growing conditions, stresses and management approaches. Processes for identifying optimally-adapted varieties and delivering information to farmers, end-users and stakeholders will be put in place. This will include the creation of the High Performance Low Risk (HPLR) varieties as a concept and a brand potentially leading to harmonisation of VCU testing across the EU. InnoVar will focus on wheat initially, and apply the InnoVar approach to other major crops. Developments and advances achieved will also influence breeding processes. This project will take variety information to the next level in four ways: (i) providing information on new DUS and VCU characters and identifying synergies; (ii) developing varieties with proven suitability for the various growing scenarios; (iii) making this information available to farmers throughout the EU, and (iv) disseminating the information in readily accessible and easily updated digital formats. Cutting-edge science will be integrated with tried and tested DUS and VCU processes to deliver an invigorated EU variety evaluation system capable of delivering increasingly productive and more sustainable cropping to meet the challenges arising from population growth, food security and clim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of continuous two-dimensional defect-free materials by liquid-metal catalytic routes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Two-dimensional materials (2DMs) such as graphene, hexagonal boron nitride, silicene and others, are currently amongst the most intensively studied classes of materials that hold great promise for future applications in many technological areas. However, the main hurdle against practical utilization of 2DMs is the lack of effective mass production techniques to satisfy the growing qualitative and quantitative demands for scientific and technological applications. The current state-of-the-art synthesis method of 2DMs involves the dissociative adsorption of gas-phase precursors on a solid catalyst. This process is slow by nature, inefficient, and environmentally unfriendly.Our analysis and recent experimental evidence suggest that using liquid metal catalysts (LMCats) instead of solid ones bears the prospect of a continuous production of 2DMs with unprecedented quality and production speed. However, the current knowledge about the catalytic properties of LMCats is extremely poor, as they had no technological significance in the past. In fact, there exist no well-established experimental facilities, nor theoretical frameworks to study the ongoing chemical reactions on a molten surface at elevated temperatures and under a reactive gas atmosphere. Our aim is to establish a central lab under supervision/collaboration of several scientific/engineering teams across Europe to develop an instrumentation/methodology capable of studying the ongoing chemical reactions on the molten catalyst, with the goal to open two new lines of research, namely in situ investigations on the catalytic activity of LMCats in general, and unravelling the growth mechanisms of 2DMs on LMCat surfaces in specific. The gained knowledge will be used to establish the first efficient mass production method fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans' (BACCHUS).

assistant: **Concept**

The main objective of the BACCHUS project is to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans.  To achieve this, the BACCHUS consortium has assembled 12 leading Research & Technological centres and 16 SMEs (with ca 30% of the EC requested contribution allocated to the SMEs). BACCHUS thus contains SMEs directly involved in developing food products and pursuing health claims, experts in health claims legislation and the EFSA review process, and academic and industry partners who provide high quality food and health research that can underpin health claims. Existing SME-developed products that have clear potential for obtaining favourable opinions for health claims have been selected as test cases for study. These have been aligned with a series of work-packages each of which addresses key aspects of the EFSA health claim evaluation process (legislation and dossiers; product/bioactive characterisation; habitual intakes; bioavailability; mechanisms and biomarkers; clinical trials evidence of health benefit) that will deliver tools, processes and high quality original science. Scientific results and best practice guidelines will be made publically available and thus support future claims for industry. The scope and completeness of the existing bioactive database (eBASIS) that includes both compositional and biological effects data will be extended and developed as a sustainable tool with various training materials. All outcomes will be disseminated broadly by direct engagement with SMEs via an existing Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Micro-guts for the study of translocation of microplastic' under Horizon 2020.

assistant: **Concept**

The presence of micro and nanoplastics is now documented in the drinking water, ocean, marine invertebrates and fishes. Their toxicity for humans is still mostly unknown, as well as their capacity to translocate through the gut barrier, especially since it depends strongly on the size, shape, surface state, material of these plastics, which are strongly heterogeneous or even contaminated by organic or toxic compounds. In this project, I propose to develop new in-vitro systems in order to quantify the translocation of environmental nano and microplastics obtained from plastic wastes, through the gut epithelial barrier. This proposal includes the development of 1- microphysiological systems mimicking that barrier and 2- detection techniques for the characterization of micro and nanoplastics directly inside biological tissues (Raman-SERS, SEM, AFM, confocal microscopy) or in liquids.


**Keywords:** microfluidic, organ-on-chip, microplastic, gut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of Multiscale Analysis of Pancreatic Beta-Cell Function by Imaging Islets in situ within the Intact Pancreas' (Multi-Islet) targeting Seventh Framework.

assistant: **Abstract**

Type 2 diabetes is a global and costly healthcare problem associated with impaired insulin secretion from pancreatic beta-cells as well as peripheral insulin resistance. The range of complications associated with aberrant glucose homeostasis is vast, and some severely impact the ability of diabetes-sufferers to lead a normal life. Despite significant research funding over the past three decades, the incidence of diabetes continues to grow. The finding in recent years that genes predispose to diabetes has ignited a search for the mechanisms through which diabetes-associated genes predispose to diabetes. At the single cell level, gene-silencing/transduction studies using cell cultures have shown that gene polymorphisms consistently associated with diabetes, such as those for TCF7L2, lead to defects in insulin processing, storage and secretion. At the whole-animal level, beta-cell specific deletion of TCF7L2 leads to marked glucose intolerance. Yet, directly extrapolating findings between these two levels is complicated by the dependence of beta-cells on their tissue context for proper function. To overcome this obstacle, and adequately reconcile these observations, further studies are required to assess how type 2 diabetes-associated genes alter beta-cell function at the single cell and population levels in the intact tissue. By applying multiphoton imaging and optogenetics to murine models of type 2 diabetes, new insights into the influence of identified risk genes on beta-cell behavior at multiple levels can be obtained. It is hoped that the findings stemming from these studies will allow new therapeutic targets to be identified in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Bird predation on mussels in conflict with aquaculture in special protected areas' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content In Ireland, recently important areas for wintering birds are designated Special Protected Area and are protected under European and national low. Several sites are also important areas for shellfish cultivation. Field data on the interactions between bird populations and the intertidal mussel beds is limited, especially in Ireland. Essential research into these interactions is necessary to be able to develop a management plan for a sustainable use of these shellfish areas. The aim of this project is to give an overview over the conflicts occurring between aquaculture and nature conservation in the different Special Protected Areas. In selected areas, the interactions between bird and mussel populations will be studied in detail. Estimations of the mussel consumption through birds will be made, its effect on the mussel populations and its relation to other elimination factors will be evaluated. The effect of size selection of the different bird predators and the flexibility in the food composition of each bird species will be studied. Ultimately, recommendations for a sustainable management plan will be made. Training content (objective, benefit and expected impact) Young scientists will learn to apply different field and laboratory methods appropriate for this research field. They will learn how to evaluate predation effects by birds on mussel populations and how to adapt their model to the local situation. Links with industry / industrial relevance (22) There are links with shellfish cultivation. The aim is to advise the industry of shellfish cultivation in order to have less impact on the natural environment in Special Protected Areas in Ireland.