RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reconstructing atmospheric oxidation processes in the past with clumped isotope measurements in O2 trapped in polar firn and ice air' (2014-2020).

assistant: **Innovation**

Air trapped in polar ice cores provides a unique archive of atmospheric composition in the past. However, reactive gases are not stable in ice core air, and therefore no paleo-proxies exist that allow reconstructing the oxidation capacity of the past atmosphere from ice cores. Recent study shows that isotope exchange between highly reactive oxygen atoms (O(3P)) and relatively non-reactive O2 in the atmosphere imprints an isotope signal in the “clumped” isotopic composition of atmospheric O2, which can be a tracer for the abundance of O(3P) in the troposphere. Clumped isotopes are isotopologues containing more than one heavy isotope (e.g., 18O18O), and they are now detectable at high precision using modern technology. I propose here to develop these novel clumped isotope measurements on O2 into a tool to reconstruct the oxidative capacity in the past atmosphere from O2 trapped in firn and ice core air. I will first verify the hypothesis that the large clumped isotope signal originates from fast O(3P)+O2 exchange at low temperatures in the stratosphere, and that this signal is only partially erased by further exchange in the troposphere, where much lower O(3P) and higher temperatures prevail. Clumped isotope analyses on O2 trapped in ice cores will then be used to decipher past variations in atmospheric oxidation processes with a temporal resolution of decades to millennia. I am particularly interested in determining the effects of both natural (glacial-interglacial) climate variability and anthropogenic climate change associated with fossil fuel combustion on oxidation processes in the atmosphere. My experience in the field of clumped isotopes fits perfectly to the expertise of the host group in atmospheric research using isotopes, and the project will make use of the ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mediterranean multimedia-multimedia support centre for culture arts' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to create a multimedia support network, based on four Mediterranean regions, dedicated to fostering the development of European multimedia applications in the area of culture and arts.The main objectives of M.Cube will be to:- improve the competitiveness of the European multimedia industry, enhancing the quality of its products, improving the business capabilities of the enterprises, attracting funds for the new developments, etc.- create a critical mass to penetrate the consumer market at international level; M.Cube will put together many small developers to address the market through big distributors.- exploit the enormous European potential in terms of cultural contents.Investigations already carried out by the partners have shown that besides the need for technological, marketing and management support in the multimedia industry. The key role of the editorial function is missing in its organisation. This editorial function should link the developers with the distributors and connect all the other actors/suppliers. The first aim of M.Cube is to help establish this editorial function. After establishing the editorial base, engineering, financing and distributing new products will be the first of the multimedia manufacturers' requirements to be met. Then the focus will move to the other technical services needed to structure the manufacturing side of participating companies, to raise originality and quality of the products, cut costs and build the multimedia business on a genuine industrial basis. This best practice implementation will find in European culture and arts a particularly appealing application.Supplying multimedia support services to cultural users is a strategic task for M.Cube. Museums, galleries, collections, public administrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Molecular imaging of redox processes in cancer'.

assistant: **Concept**

Background:The ability of cancer cells to survive extreme levels of oxidative stress, an imbalance of free radicals and antioxidants, plays a role in disease aggressiveness. However, there are currently no methods to image the spatial distribution of redox state in the clinic and few preclinical methods have the potential for translation. Our long term goal is to develop sensitive and specific imaging tools with which to study how redox processes contribute to cancer drug resistance, with a view to translating these results into clinical applications.Aims:We aim to explore the hypothesis that the ability of cancer cells to detoxify free radicals is linked to their capacity to evade cell death during therapy. We will perform our studies to test this hypothesis first using live cell microscopy, then through imaging in small animal models.Methods:Existing methods for measuring redox state in live cells, including fluorescence and Raman microscopy, will be studied during modulation of the external environment and derivation of drug resistance. These readouts will be compared to classical biochemical assays of oxidative stress upon cell harvest. A low cost, high sensitivity instrument will then be developed to image these same contrast mechanisms through endoscopy in colorectal cancer mouse models. Finally, a novel “smart” contrast agent concept will be explored to enable deep tissue redox imaging, using both fluorescence endoscopy and photoacoustic tomography.How the results of this research will be used:If elevated antioxidant capacity is causative in the development of drug resistance, the results of this work will provide new strategies for detecting relapse and may aid clinical trials of therapies to target this adaptation. Ultimately, the Marie Curie Career Integration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Rheology of yield stress fluids: a multiscale approach' (RheoYield), addressing dissemination and exploitation.

assistant: **Impact**

Yield stress fluids defy our conventional notions of liquid and solid, keeping their shape as soft solids at low loads, yet yielding and flowing like liquids at larger loads. They can then suffer arbitrarily large deformations in this liquid state, but will recover a solid state if the load is removed. Their internal microstructure and macroscopic shape are thus determined directly by the processing history they experience. Such materials are all around us: in colloids, microgels, emulsions, foams, pastes, slurries, and their biological counterparts. They find widespread applications in foods, pharmaceuticals, construction, oil extraction, lubricants, coatings, etc. Despite this importance to so many engineering processes, we still do not understand how their remarkable macroscopic rheological (deformation and flow) properties emerge out of the collective dynamics of their constituent microscopic substructures: colloid particles, microgel beads, emulsion droplets, etc. Addressing key questions emerging from recent experiments, RheoYield aims to build new theories to inform and potentially transform our understanding of the rheology of yield stress fluids. Within a multiscale approach, the project will capitalise on rapid recent progress in understanding how microscopic rearrangement events cooperate to give macroscopic flow. Using theoretical and computational tools that I have recently developed, and new ones that will be developed here, RheoYield aims to: 1. Identify the microscopic changes that take place in a soft solid as it slowly yields into a fluidised state. 2. Understand the profound influence of boundary physics on bulk yielding. 3. Develop the first microscopically founded continuum constitutive model that captures all the key features of yield stress rheolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Regulation of muscle stem cells by ERRgamma'.

assistant: **Innovation**

Skeletal muscle is a highly plastic tissue capable of spontaneous repair in response to injury via the recruitment of muscle stem cells called the satellite cells. These cells are localised within the myofibre basal lamina and are activated upon muscle damage, they proliferate and differentiate to replace the damaged muscle. Satellite cells are the key rate-limiting step for successful repair and the transcriptional cues that emanate from the skeletal muscle to activate regeneration are unclear. Thus, discovery of key molecules that regulate satellite cell activation will accelerate the ability to stimulate muscle repair. Estrogen related receptors (ERR isoforms α, β and γ) are a sub-family of orphan nuclear hormone receptors that have been identified as major regulators of cellular and mitochondrial metabolism. Skeletal muscle-specific overexpression of ERRγ has been shown to drive metabolic and angiogenic muscle reprogramming in both health and disease. This project will test the hypothesis that targeting ERRγ in skeletal muscle will improve the myofibre regenerative capacity via satellite cell recruitment and secretion of growth factors. Identification of the underlying mechanisms will provide new knowledge that can be exploited to develop new therapeutic avenues for promoting satellite cell recruitment and myofibre regeneration in terms of injury or degenerative conditions like ageing and muscle wasting disorders. The hypothesis will be tested by addressing the following specific aims: 1) To establish the satellite cell proliferation and differentiation profiles in ERRγ transgenic muscles at baseline and in response to acute eccentric exercise. 2) To investigate the effect of ERRγ on satellite cell recruitment in response to muscle injury. 3) To determine the interp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project '"Investigating autophagy enhancement as a therapeutic approach for the treatment of Rett syndrome.""""'.

assistant: **Objectives**

Intellectual disability (ID) is a generalized neurodevelopmental disorder characterized by deficits in mental abilities, social and motor skills. ID affects about 2-3% of the general population and it is mostly caused by a genetic lesion. Accordingly, mutations in the X-linked MECP2 cause Rett syndrome (RTT), a devastating neurological disorder that, because of its incidence (1:10000), represents the most common form of severe ID in girls worldwide with no approved cure. RTT profoundly affect the lives of affected individuals and their families and represent a considerable burden for health care providers across Europe.  While the molecular pathways causing RTT remain mainly unknown, it is recognized that they ultimately lead to prominent alterations of synaptic transmission and neuronal activity.  Autophagy is a catabolic process that sequesters aberrant organelles and macromolecules into autophagosomes and delivers it to lysosomes for degradation. Autophagy participates in a variety of events in neuronal cells including synaptic growth and neuronal activity, however, its possible involvement in neurodevelopmental disorders is still mainly neglected.  In accordance with a recent study applied to human samples, my preliminary data suggest that autophagy is altered in RTT. By using cellular models of the disease, this project aim at characterize the therapeutic potential of restoring the autophagy pathway in RTT. (i) I will dissect the defective autophagy signaling cascade; (ii) identify target molecules that restore the neuronal dysfunction and synapses transmission; (iii) provide therapeutic targets to treat RTT and other nerudevepmental disorders with impaired autophagy function. My results have the potential to be translated into therapeutics. This research will cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Antimicrobial nano-coatings for hospital textiles to prevent the spread of healthcare associated infections'.

assistant: **Innovation**

The main objective of NANO-PROTECT is to develop innovative antibacterial, antifungal, antiviral, and anti-biofilm (4A) nano-enabled coatings for medical textiles, upholstery fabrics, and personal protective equipment (PPE) which would be susceptible to pathogens contamination in hospitals. This proposal will focus on designing a pallet of antibiotic-free nanocomposites for coating medical textiles. Novel inorganic nanoparticles with broad antimicrobial activities comprising antibiotic-resistant strains and viruses will be fabricated. The designed nanoparticles will be used for fabricating nano-enabled inorganic/bio-based composites comprising different mechanisms of anti-biofilm and antimicrobial activities. The durability of the antimicrobial function will be monitored by visual indicators. Safer water-based sonochemistry, bio-based metal reduction, self-assembling, enzymatic crosslinking, and a combination thereof would be employed. Moreover, versatile high-precision technologies for nanometric coatings (spray coating, and ink-jet printing) will be tested with a lower quantity of NPs requirements. Further, single-step sonochemical fabrication and coating will be evaluated to make “ready-to-use” products with nano-structured antimicrobial surfaces. Therefore, NANO-PROTECT's nanotechnology-based solutions will provide environmental health safety for patients, visitors, and professionals.


**Keywords:** Nanocoatings, textiles, nanomaterials, healthcare-associated infections
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NETwork of excellence in microelectronic system integration technologies-PACKaging' (NETPACK).

assistant: **Concept**

A Network of Excellence in Microlectronic Packaging (NETPACK III) will be installed which continues the previous activities of NETPACK I and NETPACK II. During the last project more than 450 companies and institutes became a member of NETPACK. The activities in the network will be done within five workpackages. In the WP Packaging Store, Vision Lab and Education Pool information on advanced packaging technology and student education will be collected from the network members and provided by an internet based information system. The WP NETPACK Club will install a communication platform for the network members. The WP Management will coordinate the network activities and establish contacts to other networks and packaging organizations worldwide.Objectives:- to install an internet based Packaging Store, which provides advanced information on materials, equipment and services for the microelectronic packaging- to provide information on future trends in products and technologies- to strengthen significantly the education of European packaging engineers- to encourage discussion between network members by am internet communication platform- to improve constantly the network performance by feedback from the members.Work description:A Network of Excellence in Microlectronic Packaging (NETPACK III) will be installed which continues the previous activities of NETPACK I and NETPACK II. During the last project more than 450 companies and institutes became a member of NETPACK. The activities in the network will be done within five workpackages. In the WP Packaging Store, Vision Lab and Education Pool information on advanced packaging technology and student education will be collected from the network members and provided by an internet based information system. The WP NETPACK Club wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of loss-of-heterozygosity in cancer development and progression' (DELCANCER) under Seventh Framework.

assistant: **Objectives**

Somatically acquired loss-of-heterozygosity (LOH) is extremely common in cancer; deletions of recessive cancer genes, miRNAs, and regulatory elements, can confer selective growth advantage, whereas deletions over fragile sites are thought to reflect an increased local rate of DNA breakage. However, most LOHs in cancer genomes remain unexplained. Here we plan to combine a TALEN technology and the experimental models of cell transformation derived from primary human cells to delete specific chromosomal regions that are frequently lost in cancer samples. The development of novel strategies to introduce large chromosomal rearrangements into the genome of primary human cells will offer new perspectives for studying gene function, for elucidating chromosomal organisation, and for increasing our understanding of the molecular mechanisms and pathways underlying cancer development.Using this technology to genetically engineer cells that model cancer-associated genetic alterations, we will identify LOH regions critical for the development and progression of human cancers, and will investigate the cooperative effect of loss of genes, non-coding RNAs, and regulatory elements located within the deleted regions on cancer-associated phenotypes. We will assess how disruption of the three-dimensional chromosomal network in cells with specific chromosomal deletions contributes to cell transformation. Isogenic cell lines harbouring targeted chromosomal alterations will also serve us as a platform to identify compounds with specificity for particular genetic abnormalities. As a next step, we plan to unravel the mechanisms by which particular homozygous deletions contribute to cancer-associated phenotypes. If successful, the results of these studies will represent an important step towards
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Black holes and their host galaxies: coevolution across cosmic time', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Galaxy formation is one of the most fascinating yet challenging fields of astrophysics. The desire to understandgalaxy formation has led to the design of ever more sophisticated telescopes which show a bewildering varietyof galaxies in the Universe. However, the degree to which an interpretation of this wealth of data can succeeddepends critically on having accurate and realistic theoretical models of galaxy formation. While cosmologicalsimulations of galaxy formation provide the most powerful technique for calculating the non-linear evolution ofcosmic structures, the enormous dynamic range and poorly understood baryonic physics are main uncertaintiesof present simulations. This impacts on their predictive power and is the major obstacle to our understanding ofobservational data. The objective of this proposal is to drastically improve upon the current state-of-the-art by i)including more realistic physical processes, such as those occurring at the sphere of influence of a galaxy’s centralblack hole and ii) greatly extending spatial dynamical range with the aid of a novel technique I have developed.With this technique I want to address one of the major unsolved issues of galaxy formation: “How do galaxies andtheir central black holes coevolve?” Specifically, I want to focus on three crucial areas of galaxy formation: a) Howand where the very first black holes form, what are their observational signatures, and when is the coevolution withhost galaxies established? b) Is black hole heating solely responsible for the morphological transformation andquenching of massive galaxies, or are other processes important as well? c) What is the impact of supermassiveblack holes on galaxy clusters and can we calibrate baryonic physics in clusters to use them as high precisioncosmolog