RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Clean Hydrogen-rich Synthesis Gas' to be submitted under Sixth Framework.

assistant: **Abstract**

The transport sector represents an increasing share of the total fossil fuel use in the World. In order to fulfil the obligations of the Kyoto Protocol, the World must reduce the transport sector's dependence on oil. One important way of achieving this is to increase the use of vehicle fuels produced from renewable. This project will develop and optimise an energy-efficient and cost-efficient method to produce hydrogen-rich gases from biomass, including residues. This gas can then be upgraded to commercial quality hydrogen or to synthesis gas for further upgrading to liquid fuels such as DME and methanol or Fischer-Tropsch diesel.The achievable yield of motor fuel from cellulose biomass is higher for fuels derived via the gasification/synthesis gas route than via the hydrolysis/fermentation route as by using the first route all carbon can be converted to fuel whilst through the second route only carbon convertible to sugar can yield motor fuel. This fact also means that the production cost for biomass-derived motor fuels produced via gasification can be expected to be lower than those produced via fermentation.The hub of the project will be the Varnamo Biomass Gasification Centre in Sweden and the use of the existing and unique biomass-fuelled pressurised IGCC (integrated gasification combined-cycle) CHP (combined heat and power) plant in Varnamo (presently owned by one of the participants in this proposal) as a pilot facility. By building this Centre around this plant, gasification research and demonstration activities can be conducted at a much lower cost than if new equipment were to be built. Within this particular project, new process equipment will be developed and tested and implemented in this pilot facility to produce clean gas, rich in hydrogen, which can be u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dissecting Regulatory Networks That Mediate Dendritic Cell Suppression' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Recent advances have shown that therapeutic manipulations of key cell-cell interactions can have dramatic clinical outcomes. Most notable are several early successes in cancer immunotherapy that target the tumor-T cell interface. However, these successes were only partial. This is likely because the few known interactions are just a few pieces of a much larger puzzle, involving additional signaling molecules and cell types. Dendritic cells (DCs), play critical roles in the induction/suppression of T cells. At early cancer stages, DCs capture tumor antigens and present them to T cells. However, in advanced cancers, the tumor microenvironment (TME) disrupts the crosstalk between DCs and T cells. We will take a multi-step approach to explore how the TME imposes a suppressive effect on DCs and how to reverse this hazardous effect. First, we will use single cell RNA-seq to search for genes in aggressive human and mouse ovarian tumors that are highly expressed in advanced tumors compared to early tumors and that encode molecules that suppress DC activity. Second, we will design a set of CRISPR screens to find genes that are expressed in DCs and regulate the transfer of the suppressive signals. The screens will be performed in the presence of suppressive molecules to mimic the TME and are expected to uncover many key genes in DCs biology. We will develop a new strategy to find synergistic combinations of genes to target (named Perturb-comb), thereby reversing the effect of local tumor immunosuppressive signals. Lastly, we will examine the effect of modified DCs on T cell activation and proliferation in-vivo, and on tumor growth.  We expect to find: (1) Signaling molecules in the TME that affect the immune system. (2) New cytokines and cell surface receptors that are expressed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Improving the utilisation and quality of low-value fish by processing' in the context of a Fifth Framework call.

assistant: **Objectives**

The aim is to improve the utilisation and quality of low-value fish by processing. Systematic and innovative studies by collaborating partners in Europe, Africa and Asia will address problems of over-fishing and lack of processing to improve food supply. Under-utilised fish species, two each in Ghana, Namibia, Kenya, India and Malaysia will be characterised and processed using a simple cost-effective extruder which will be designed in Europe and assembled in the developing countries. Extruded and dried products(infant foods, cereals and snacks) made from fish combined with other local crops will be assessed for nutritional and organoleptic quality. In addition, added-value products including fish isolate, fish oil and gelatine (from waste skin) will be extracted. Biochemical changes in the dried products and preservation using natural antioxidants form local crops, will be investigated to improve quality and food safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fluid Flow & Heat Transfer within the Roating Cavities of Internal Cooling Air Systems of Gas Turbines' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The project has successfully delivered:- An extensive data base of pressure, temperature and flow measurements for each of the five rotating flow systems;- Numerical models, in the form of Computational Fluid Dynamics (CFD) and Finite Element (FE) models which have been validated against selected experimental test cases, and which are believed to capture the important physical mechanisms which govern flow and heat transfer in each rotating flow system;- Through analysis and interpretation of the experimental and numerical results, an improved understanding of the important physical phenomena, and guides to the optimum modelling method for a given situation;- Correlations of experimental and numerical analysis results for three of the five rotating flow systems.Objectives and content This project is concerned with the problems of heat transfer and fluid flow within gas turbine internal cooling air systems, with the aim of improving the design of the latter for both advanced aircraft and electrical power generation gas turbines. Participants in the proposal are ten major European engine manufacturers and four Universities specialising in this type of work. The approaches will include; (a) advanced experimental work to obtain much improved data under representative operating conditions, (b) evaluation of flow and heat transfer models and CFD codes, (c) development of improved 3D models and correlation's for design purposes and (d) establishing a more standardised European approach to these problems. The five separate, but related, topics which will be studied are:  Turbine annulus hot gas ingestion control.  Airflow and heat transfer in rotating cavities with axial and axial/radial through flow.  Compressor stator well heating.  Turbine cooling air pre-swirl systems.  Airf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Extending the science perspectives of linear wires of carbon atoms from fundamental research to emerging materials', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EspLORE aims at addressing the potential of carbon-atom wires for developing novel functional coatings in an application-oriented approach. Carbon-atom wires, based on sp-hybridization, are the ultimate 1-dimensional carbon nanostructure (1-atom diameter) with functional properties strongly dependent on the wire length and termination. The design and control of the wire structure opens the way to build materials with tunable properties, which is at present a largely unexplored topic. The core concept of EspLORE is to exploit the present fundamental knowledge of carbon-atom wires as isolated molecules/nanostructures to explore the applied science and engineering of new materials in the form of thin film assemblies and nanocomposites, so to fill the large existing gap between basic science and engineering. To this aim the main challenging goals are: 1) the controlled synthesis of wires; 2) the development of strategies to assemble wires in thin films and nanocomposites; 3) the exploration of potential use of wire-based materials in direct energy conversion devices (e.g. photovoltaics, water splitting, fuel cells).The proposed methodology includes fabrication of wires by physical methods, their deposition/assembling on surfaces, and the experimental study of structural, electronic and optical properties. Structure-property relationship is investigated at a multiscale level, moving from the single wire level (atomic scale) to multi-wire interactions (nanoscale) and up to extended systems (macroscale). The outcomes of the project will put the foundations for the materials engineering of wire-based systems and their realistic implementation in advanced technological applications. These materials, able to provide complementary properties to graphene, will synergistically contr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genetic engineering of conjugative relaxases', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content In bacterial conjugation, DNA is transferred from donor to recipient bacteria (or to yeast). In T-DNA transfer, structurally and functionally related to conjugation, DNA is transferred from Agrobacterium tumefaciens to plant cells. The aim of the proposed project is to investigate DNA processing during conjugation, using plasmid R388 as a model system. The relaxase protein TrwC is the key enzyme in this process. It is unique among relaxases since it catalyses intermolecular site-specific recombination between two oriT-containing DNA molecules. The biochemistry of TrwC will be analysed in detail, | to convert it to a technological tool. A second unique relaxase is VirD2, the relaxase of Agrobacrerium plasmids, that pilots the T-DNA to the plant cell nucleus. We propose to engineer TrwC by adding some features of VirD2 to achieve high frecuency site-specific DNA integration in yeast, plant and animal cells.Training content (objective, benefit and expected impact) The trainee should become an expert in the biochemistry of relaxases. This technology should have an impact in genetic engineering projects using eukaryotic hosts. Integration of foreign DNA to specific genomic sites will be more efficient and | abolish differences in gene expression and stability common to alternative methods. Other biotechnological applications of these enzymes will be explored.Links with industry / industrial relevance (22) None.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The physics of three dimensional chromosome and protein organisation within the cell' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding the fundamental mechanisms behind the functioning of cells and their interior has long been a biology-only enterprise. This view has radically changed in the last decade or so, culminating in the invention of a whole new field, named 'cell physics', which uses the tools of physics to gain a more quantitative and deeper understanding of the inner working of a cell. The aim of my research fits broadly in this new field, although the scale of the computational studies which I plan are thus far unprecedented. I will focus my programme on the spatial organisation of DNA and chromosomes, proteins, and DNA-protein networks within the intracellular environment. I will therefore aim to answer questions such as: How is DNA organised in living cells, such as bacteria and eukaryotic nuclei? What is the role of proteins in DNA and chromosome folding in vivo? How does genome organisation differ in healthy and sick nuclei? How do proteins and RNA move around and self-organise into supramolecular structures in the crowded intracellular environment? I propose to work on the simulation and theoretical side of these problems, while maintaining very close collaborations with key experimental players in these fields who will provide me with a large number of experimental data (obtained by more sophisticated version of the original well-known 'chromosome conformation capture' technique) to maximise the impact and output of the modelling work.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Graphene-based All-Optical Technology Platform for Secure Internet of Things' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The need for a next-generation computing platform becomes clear from IoT and 5G/6G and their high performance and low power requirements. Now, graphene and 2D materials (2DM) offer the unique ability to enable highly confined nonlinear interactions of light at low powers and at extremely low response times in the femtosecond range. However, it must be integrated with CMOS low-loss silicon nitride (SiN) platform that facilitates the possibility to create circuits for fast, low power, high bandwidth, general purpose computing and memory completely in the optical domain. As the most important challenge comes from the maturity of the graphene processes with standard CMOS environments, the main goal of GATEPOST is to fabricate and demonstrate a radically new graphene-based all-optical data processing platform, integrated and tested in a real CMOS pilot line. As a user case, we focus on a network security device for distributed denial of service (DDoS) detection and network packet inspection. Even though on average 170 cyber-attacks are performed per IoT device per day, there is still a huge lack of security due to the added power, latency, operating costs and bandwidth limitations involved. This is unacceptable, especially considering that the cybercrimes topped an estimated $318 billion in 2021 alone. With our graphene-based computing platform, we will show how low-power, low-latency and high bandwidth network security is ready for the IoT and 5G/6G future.  The full system showcases the unique expertise of each consortium member in all-optical digital logic, neuromorphic computing, memory and ultra-fast clock generation. These components are realized in the 2D-Experimental Pilot Line at IHP, allowing for scalable fabrication and strengthening the EU’s supply-chain in high-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MULTI-functional metallic SURFaces via active Layered Double Hydroxide treatments' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of the proposal is development of active multi-functional surfaces with high level of self-healing ability on the basis of Layered Double Hydroxide (LDH) structures formed on different industrially relevant metallic substrates. The main idea of the project is based on “smart” triggered release on demand for functional organic or inorganic anionic compounds intercalated into intergallery spaces of LDHs. The active functionality is achieved via controllable substrate-governed growth of LDH architectures on Al, Mg and Zn based alloys. The functional anions such as corrosion inhibitors, biocides, drugs, or hydrophobic agents are introduced into the intergallery spaces during the growth of LDH or upon a post-treatment stage. The release of the functional agents occurs only on demand when the respective functionality is triggered by the relevant external stimuli such as presence of anions or local pH change. The proposal focuses on two main applications, namely aeronautical and automotive. The active LDH treatments can bring significant benefits when applied in these situations. The respective relevant substrates are chosen as the main objects of interest: Mg alloys for both applications; Al alloys for both transportation industries as well; galvanized steel as a main material for automobiles. Moreover the suggested surface treatments, especially the one with active self-healing ability, are also considered for light-weight multi-material structures which are prone to fast galvanically-induced corrosion. The increase of the fault tolerance and reliability of hybrid designs is aimed in this case. The suggested surface treatments can offer possibility for fast implementation of the process at industrial level. The main expected impacts are related to the impr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Protecting wind-turbine leading edges with nanoengineered superhydrophobic urethane coatings' (SUNCOAT) targeting Horizon 2020.

assistant: **Abstract**

Wind energy is a vital component in meeting EU’s the Strategic Energy Technology (SET) plan and Europe’s ambition to become number one producer of renewables. Reducing operation and maintenance (O&M) costs are of paramount importance. The most serious problem affecting the wind industry is water erosion of the turbine blades. The blade leading edges are most susceptible, particularly in offshore turbines that are often battered by the water hammering mechanism of rain and seawater splash impact, exposure to the solar (UV) radiation and harsh fluctuations in temperature which lead to accretion of dirt, contaminants and ice. Progressive increase in the size of the blades has increased tip-speed of the blades exacerbating these erosion issues and increasing O&M costs for wind farms. Therefore, robust and environment friendly surface treatment solutions are urgently required to solve this most significant problem in an industry critical for Europe to meet its energy security and sustainability goals.Through PI’s ERC Grant (NICEDROPS), a robust and flexible nanoengineered coating formulation was developed. These coatings are applied through scalable approaches. They combine flexibility and superhydrophobicity to achieve exceptional liquid impalement resistance without compromising the mechanical robustness; the breakthrough published as a cover article in Nature Materials. In SUNCOAT we will advance this by one more crucial step – by introducing water based coatings formulations, to make our solution environment friendly and VOC-free. The technology is an innovative solution to the wind energy industry’s number one problem and it can deploy on existing infrastructure during routine maintenance cycles as well as in-factory at point of manufacture. Given the expense of blade r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Application of senario and prospective analysis techniques to study the future of Castilla-leon's mining areas'.

assistant: **Objectives**

The decline and de-industrialisation of mining areas in the European Union is a process quite known and studied since the l950's and 1960's, depending on the country. Most often the studies focused on the economic history of the mining industry firms as well as the types of problems those areas currently suffer. In the last years the European strategies have adopted a renewed approach and point to the regeneration of the areas. In such context, each mining area's actors need to evaluate costs, limits and opportunities of the policy and adopt decisions with a vision of the future. The research we are proposing consists of developing alternative Scenarios about the future of the territorial structure, the economic activities, employment and research and technical developments required the mining areas of Castilla-Leon. The research shall contribute to the decision making of the Regional Government of Castilla-Leon and to design of its strategy and priority investments in the Mining Areas.