RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Comparing the Predictive Ability of Forecasting Models' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Constructing accurate predictions on different macroeconomic variables is a key issue for any central bank and other policy making institutions. For example, obtaining accurate inflation forecasts is important for setting interest rates. These institutions typically rely on a set of models to construct their forecasts and the question that often arises is which of these models performs the best in terms of predictive ability. The purpose of this project is to show that, when strong identification on these models is lost (an issue that is prevalent in many models used for prediction), our inference based on standard tests, that compare these models' predictive accuracy, can be misleading.  A policy maker could thus falsely conclude that a particular model outperforms some other models in her set of competing models. This project will answer thus the question of how to perform correct inference about predictions in the setting in which the models are affected by identification deficiencies. To this end, I propose methods that make the standard predictive ability tests robust to this issue, while appropriately accounting for the parameter estimation error. The asymptotic distribution of the statistic will be derived under loss of strong identification. Bootstrap inference will be developed in order to obtain correct critical values. Monte Carlo simulations will analyze the finite sample properties of bootstrap critical values. Empirical studies will illustrate the consequences of using a standard vs. a bootstrap critical value. Results emerging from this project, will be of interest to a large academic community, central banks and other governmental organizations - that could take-up the new knowledge for policy making, as well as businesses that produce predictions - that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Formal reuse in transportation software', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the field of Automatic Train Control Systems, it is clearly cost ineffective to develop a new system for each line, even if each line may prescribe specific characteristics (e.g. signalling; transmission). The overall goal is to specify a generic Automatic Train Control system in order to enable different instantiations fitting the distinctive features of the lines. The expected benefit is not only cost effectiveness, but also the ability to shorten the time delivery which may be a decisive advantage to fit customer requirements.THE EXPERIMENTA well advised strategy is necessary to progress towards the overall objective.One step, under way in a baseline project, is to enable the reuse of software pieces through reengineering of existing software components using a formal method. The next step is to work out the reuse issue at the system level. The experiment consists in:- reengineering a part of an Automatic Train Control System to explicit the common functionalities and the specific ones. The RDD 100 tool will be used to achieve this task;- linking the system description with the software components specified using the formal method.A dozen people are involved in the baseline project and experiment.EXPECTED IMPACT AND EXPERIENCEMTI expects to explicit and strengthen its know-how on system/software engineering by drawing up a more formal and generic basis on which Automatic Train Control systems and software can be derived, to gain in productivity and in time to market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Therapeutic Drug Monitoring with Smartphone-integrated Surface Enhanced Raman Spectroscopy' (THERA).

assistant: **Innovation**

Therapeutic drug monitoring (TDM) is an essential tool for measuring the circulating concentration of specific narrow therapeutic drugs at designated intervals, in order to maximise the efficacy of the drug and avoid toxicity and adverse drug reactions. TDM is currently available only in central laboratories or large hospitals, and several barriers prevent its wide implementation in routine clinical practice. First, current technologies used for TDM (e.g. high-performance liquid chromatography – HPLC, mass spectrometry – MS) are exclusively used in central laboratories due to their cost, system size and weight, complexity of use and maintenance requirements. Second, alternative technologies (e.g. ELISA immunoassays) are analyte-specific and do not allow adaptability to new analytes (increasing costs). We verified the feasibility and clinical utility of using Surface Enhanced Raman Spectroscopy (SERS) for TDM using real plasma samples taken from de-identified patients. Importantly, our measurements were consistent with state-of-the-art data generated by LC-MS/MS. We already have experimentally shown a 0.1 μM detection limit on pure, artificial samples. Within THERA, we aim to transform our research output into a commercially-relevant (in terms of size, throughput, user friendliness and cost) product by creating a minimum viable product that will enable TDM for a wide variety of molecules. Our goal within this project is to validate this device on clinical samples and build a strong business case for it that will enable commercial exploitation. THERA will advance our SERS-based device from a current technology readiness level of 3 to 5/6. Our value proposition is a tabletop, miniaturized (smartphone-sized) device that can perform TDM on a single droplet of blood, in a mat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Our common future ocean in the Earth system – quantifying coupled cycles of carbon, oxygen, and nutrients for determining and achieving safe operating spaces with respect to tipping points'.

assistant: **Innovation**

COMFORT will close knowledge gaps for key ocean tipping elements under anthropogenic physical and chemical climate forcing through an interdisciplinary research approach. It will provide added value to decision and policy makers in terms of science based safe marine operating spaces, refined climate mitigation targets, and feasible long-term mitigation pathways. We will determine the consequences of passing tipping points in physical tipping elements for the marine carbon, oxygen, and nutrient cycles, as well as tipping points in biogeochemical tipping elements. The respective impact on marine ecosystems will be determined. Projections of the Earth system and impact studies have so far been carried out sequentially in a chain from scenarios to projections to off-line impact studies. This sequential workflow has hampered a quick response of the impact community back to revised scenarios and projections for tackling climate mitigation. COMFORT breaks new ground by bringing together experts from Earth system science, oceanography, fisheries science and ecology in a single integrated project who will work in parallel with a consistent set of analysis tools, scenarios, and interoperable models. The strength of COMFORT lies in the system-focused interdisciplinary approach as opposed to existing studies at the level of individual subsystems. The approach will be pursued with a firm link to stakeholders. COMFORT results will contribute to all four expected impacts for this call.


**Keywords:** Oceanography, biogeochemistry, ocean acidification, deoxygenation, ecosystems, fisheries, climate mitigation, Earth system modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel therapeutic strategies to treat pancreatic and lung cancer' (THERACAN).

assistant: **Concept**

This proposal is aimed at identifying and functionally validating targets with potential therapeutic value to devise novel strategies to treat two human cancers with unacceptable low survival rates and unmet medical needs: pancreatic ductal adenocarcinoma and K-RAS mutant lung adenocarcinoma. Although these tumor types have distinct pathological and clinical manifestations, they are both driven by K-RAS mutations. Hence, we expect that the proposed studies will generate synergies to accelerate the outcome of the expected results. In the first part of the proposal, we will identify those genes activated in the cancer initiating cells responsible for the onset of pancreatic and lung tumors. We reasoned that genes implicated in the initial stages of tumor development will be maintained during tumor evolution and not be affected by the intra-tumoral heterogeneity generated during tumor progression. We also propose to identify and validate genes capable of reprogramming the desmoplasic stroma characteristic of pancreatic tumors to hamper its pro-tumoral effects. Likewise, we intend to define the molecular events that control senescence, a naturally occurring process that serves as a barrier to tumor development. In the second part of the project, we will interrogate the role of known targets with suspected therapeutic value in tumor progression using a new generation of GEM tumor models that allow the temporal separation of tumor development from target ablation or inactivation. These studies will make it possible to design combination therapies capable of effectively eradicate advanced tumors. The last section of this proposal focuses on the pharmacological validation of these combination therapies using best-in-class inhibitors in state-of-the-art preclinical trial platfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of consumer behavior and heterogeneity in the integrated assessment of energy and climate policies' (COBHAM).

assistant: **Concept**

The objective of this project is to quantify the role of consumers’ behaviour on the design and assessment of policies aimed at enhancing energy efficiency and conservation and at promoting climate change mitigation. The project brings together different disciplines –namely energy policy, environmental and ecological economics, behavioral public finance, experimental economics, and technology policy- in an integrated fashion. COBHAM is designed to go beyond the standard analysis of energy and climate policies in the presence of environmental externalities, by accounting for the heterogeneity in consumers’ preferences, the role of social interactions, and the presence of behavioral tendencies and biases. The project seeks to: i) carry out innovative research in the theoretical understanding of the interplay between behavioral tendencies and environmental externalities; ii) generate new empirical data and research on individual preferences by means of original surveys and controlled experiments; iii) enhance integrated assessment models (IAMs) of economy, energy and climate with an advanced representation of consumers’ behavior. In doing so, the project will be able to provide a richer characterization of energy demand and of greenhouse gas emission scenarios, to better estimate consumers’ responsiveness to energy and climate policies, and to provide input to the design of new policy instruments aimed at influencing energy and environmental sustainable behavior. COBHAM is of high public policy relevance given Europe’s legislation on energy efficiency and CO2 emissions, and can provide important insights also outside the sphere of energy and climate policymaking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Fourier-Domain TRx solutions enabling widespread realisation of 6G' (FirstTo6G) under Horizon Europe.

assistant: **Objectives**

FirstTo6G assembles European SMEs and leading universities to develop the globally first 6G TRx technology, i.e., data converters and corresponding sub-THz frontends, which fulfils the extreme requirements for making 6G a widespread reality. These requirements include extremely wide modulation bandwidth at high signal quality, high energy efficiency, and low cost.Using a novel breakthrough microchip architecture, we will develop data converters with up to 16 GHz of modulation bandwidth, with extremely low power consumption, which are implemented in a commercial, low-cost 22nm semiconductor technology. We will also develop state-of-the-art frontend technology and integrate both parts to two full TRx solutions with unprecedented capabilities. The TRx for the frequencies <100 GHz will deliver 8 GHz of modulation bandwidth and will be realised in a monolithically integrated chip. The TRx for the frequency range of 130-175 GHz will deliver 16 GHz of modulation bandwidth and will integrate on PCB the data converters and the SiGe frontends using advanced packaging technologies. The D-band frontend will be designed based on a fully automated design flow.Key exploitable FirstTo6G results include designs for new technical concepts for data converters and the frontend, integration of high-performance TRx components in a single chip and automation algorithms for the design of frontends. We will use these results to develop and directly commercialise high performance mm-wave / early 6G products, as a basis for further research, or to spin-off new businesses.By making the widespread realisation of 6G possible, we will enable the highly positive contribution to prosperity of society which 6G will ultimately have. Critical technical knowledge will be developed and exploited in Europe b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ultimate measurement of the W boson mass with ATLAS, at the LHC' (UMWA), addressing dissemination and exploitation.

assistant: **Impact**

Widely advertised as a discovery machine, the LHC proton collider at CERN will also provide large samples of standard particles, allowing the final, most precise experimental determination of some fundamental parameters of particle physics theory. Together with the expected discoveries, these measurements will allow to elucidate the dynamics of electroweak symmetry breaking. The aim of the present project is to organize and realize a precise measurement of the W resonance parameters, and in particular the W boson mass with a target precision below 0.01%. Most LHC measurements aim at a precision of order 1%, and can be performed on a time scale of about one year, within a small group of collaborators. The measurement of the W boson mass is a special case, as its aimed precision requires perfect understanding of the experimental and physical environment. It therefore requires careful planning. Intermediate measurements of standard processes need to be performed, synchronized, and will play a key role in the final result. The primary tools serving this purpose are the study of the production properties of the J/Psi, W and Z particles in the uncertain LHC environment. These studies will allow to understand the performance of the ATLAS detector and to constrain the dynamics of proton-proton interactions, which represent a major source of uncertainty. Once the above properties are firmly established, the distributions sensitive to the W boson mass can be precisely predicted, and the fundamental parameters can be determined. The coordinator of this project has recognized expertise on electroweak physics, and has led the ATLAS Collaboration's research in this field since 2007. As argued above, the preparation of the measurement of mW requires to build and coordinate a team devo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Bispecific bi-paratopic antibodies for the treatment of cancer'.

assistant: **Objectives**

Immune checkpoint inhibitors have revolutionized cancer therapy, yet the majority of patients do not respond to current treatments, such as PD-1/PD-L1blockade. In non-small cell lung cancer (NSCLC), over 70% of patients experience immune evasion mechanisms that prevent effective immune activation. One such mechanism involves the overexpression of glycans on tumor cells, which can modulate immune responses. In this project, we propose to develop novel bispecific bi-paratopic antibodies that simultaneously target two distinct epitopes of the target. This innovative approach is designed to provide a more comprehensive blockade of immune-suppressive functions by dual engagement of the receptor. Our bispecific antibodies will be engineered and optimized to target different epitopes, enhancing their ability to restore immune function. The project will involve the engineering, structural characterization, and functional validation of the bispecific antibodies, followed by preclinical efficacy studies in NSCLC models. By this approach, these antibodies have the potential to overcome the limitations of existing immunotherapies, offering a new therapeutic option for cancer patients who are resistant to current treatments. In addition to the scientific development, this ERC PoC project is designed to develop a robust commercialization strategy, with the potential for patent filings and engagement with pharmaceutical partners. Our vision is to bring these bispecific antibodies to the clinic, ultimately aiming to improve outcomes for patients with NSCLC and other cancers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'European social survey round 3'.

assistant: **Innovation**

The 3 aims of the European Social Survey are: to chart and explain changes in Europe's social, political and moral climate; to achieve and spread standards of rigour in cross-national attitude measurement never accomplished before; and to achieve recognition for social and attitudinal indicators on a par with those currently awarded to economic indicators. The first two rounds of this important time series were core-funded by the EC under FP5, and co-funded by the European Science Foundation and numerous national academic funding bodies throughout Europe. An academically-driven, uniquely rigorous survey, the ESS is documenting and helping to interpret hitherto inadequately-charted aspects of the European condition. The wide-ranging questionnaire covers people's value orientations, their cultural perspectives and the underlying social structure of their societies. A separate data collection exercise monitors major events during fieldwork as a backdrop to an understanding of attitude change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemistry of the Quantum Kind' (QUCC) targeting Seventh Framework.

assistant: **Abstract**

There has been a long-standing quest to observe chemical reactions at low temperatures where reaction rates and pathways are governed by quantum mechanical effects. So far this field of Quantum Chemistry has been dominated by theory. The difficulty has been to realize in the laboratory low enough collisional velocities between neutral reactants, such that the quantum wave nature could be observed. Recently we have demonstrated a new way of studying cold reactive collisions by magnetically merging two fast neutral supersonic beams. After 40 years where the reactive scattering temperature was limited to above 5 K we were able to continuously tune collision energies from hundreds of Kelvin down to 10 mK temperature, a reduction of almost three orders of magnitude [A. B. Henson et. al, Science 338, 234, 2012]. Importantly, we were able to show that at low temperatures quantum effects start dominating reactive dynamics with the first observation of orbiting resonances in a reactive collision. We propose to extend our novel method to study chemical reactions in the regime of Cold Chemistry where the reactants’s de Broglie wavelength becomes larger compared to the characteristic interaction range. Theoretical predictions at low temperatures are extremely sensitive to the parameters used, routinely differing by orders of magnitude leading to contradictions waiting to be settled by experiment.Our ability to reach low enough collision energies and resolve scattering resonances will be used to bring a radical change to transient species spectroscopy. We believe that our work will not only test the central tenets of Quantum Chemistry, but will also provide valuable information to other fields, such as Astrochemistry helping to understand the synthesis of various molecules in inters