RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Roughness-induced secondary currents in arterial flows with stents' (CARE), addressing dissemination and exploitation.

assistant: **Impact**

Stents are tub nets of varied materials and geometries that are installed in narrowed (stenotic) arteries to preserve their restored diameter following surgical procedure (e.g., angioplasty). Stents add a roughness element to the otherwise smooth walls of arteries, thus altering the hemodynamic environment and the flow characteristics. CARE is inspired by recent results in wall-bounded flows, which have shown that roughness patterns of height much smaller than the flow size may generate secondary currents (SCs), large-scale streamwise vortices (comparable to the artery diameter) that alter flow structure, transport mechanisms, wall shear stress distributions and flow drag, among others. Due to their geometrical properties, stents are ideal candidates for the generation of SCs within the flow, with potentially significant effects on biological processes, e.g., restenosis. CARE will aim at advancing our understanding of SC dynamics in arterial flows by assessing their effects on key hemodynamic parameters and analysing energy exchanges. General guidelines for improved stent designs that control and modulate SCs, by preventing or promoting their generation, will be outlined.At present, roughness-induced SCs in stented arteries are largely unexplored, making the proposed research particularly timely. CARE will be based on laboratory experiments covering a range of flow conditions similar to those that can be found in the main body arteries. Different roughness patterns will be studied, including the reproduction of an actual stent. An advanced stereoscopic particle-image velocimetry system, capable of non-intrusive planar velocity measurements, will be used to study the SC patterns and their effects on wall shear stress distribution, as well as their contribution to momentu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering cerebellar mitochondrial alterations in Rett Syndrome' (MITORett).

assistant: **Innovation**

Mutations in the X-linked gene encoding methyl-CpG binding protein 2 (Mecp2) can lead to the progressive neurodevelopmental disorder known as Rett syndrome (RTT), characterized by regression in motor, social and cognitive skills, respiratory dysrhythmias and premature lethality. Although few symptomatic treatments exist, nowadays there is still no cure for this disease. Mecp2 acts as transcriptional regulator and its mutations directly affect the expression of targeted transcripts, including mitochondrial (MT) genes. Cerebellum is one of brain regions with larger energy requirements. 43% of its ATP consumption occurs in the molecular layer, where the high-energy demanding parvalbumin (PV)-neurons are positioned. Compelling evidence indicates aberrant MT morphology and functionality in cerebellar biopsies of RTT patients. However, the cellular substrate of these modifications remains largely unknown. In adult cerebellum Mecp2 is preferentially expressed in PV-positive cells. Hence, we hypothesize that RTT in PV-positive neurons might present a particular vulnerability to MT alterations. Thus, in this proposal I will implement a multidisciplinary approach to find candidate MT proteins differentially regulated in cerebellar PV-positive neurons associated with the MT impairments observed in RTT. To tackle this aim, I will perform proteomic, functional and metabolomic studies in MT immunoprecipitates from cerebellar PV-positive neurons of RTT mice. This project will thus give raise to: i) the first exhaustive list of MT proteins dysregulated in these cells in RTT ii) identification of functional and metabolomic impairments affecting MT functionality in PV-positive cells of RTT mice.MITORett project will be a breakthrough in our understanding of RTT and it will provide novel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Viral Narratives: The Role of Narratives for Economic Belief Formation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

This proposal seeks to study economic narratives. Narratives may both shape expectation formation and influence economic decisions. Using large-scale experiments, this proposal seeks to better understand the drivers of the virality of narratives as well as the mechanisms underlying their persuasive effects. A key feature of this proposal is the combination of qualitative data on economic narratives, as measured in speech recordings, with quantitative data on beliefs and economic behaviors. In Part 1, I seek to study the production and transmission of narratives. In Part 1a, I plan to study which types of narratives about economic phenomena tend to get retold and thereby go viral. The experiments will examine which features of narratives are predictive of their virality and how narratives mutate through the transmission process. In Part 1b, I plan to study how incentives to entertain shape people’s narratives and how the resulting distortions affect downstream belief formation. Part 2 aims to combine administrative data on high-stakes economic behaviors with economic narratives, as measured with speech recordings. I aim to measure narratives about the labor market effects of Artificial intelligence in large representative samples as well as among journalists, politicians and labor market experts. I then plan to relate narratives to important labor market behaviors and educational choices and to examine their origins. Finally, Part 3 proposes to study the mechanisms behind the persuasiveness of  narratives. Our experiments will allow us to cleanly identify how narratives affect belief updating and confidence compared to well-defined Bayesian benchmarks. We plan to examine the mechanisms, with a particular focus on how narratives facilitate the process of mental simulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Divide and conquer: using patient-derived tumour organoids to dissect intra-tumour immune heterogeneity of non-small cell lung cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Immune checkpoint blockade (ICB) has revolutionised treatment of patients with non-small cell lung cancer (NSCLC), but is effective in only ~20% of patients. Anti-tumour immunity is highly heterogeneous within tumours, and intra-tumour heterogeneity (ITH) is a major driver for treatment resistance. However, the mechanistic basis of intra-tumour immune heterogeneity (ITIH) is unclear, largely due to the absence of appropriate functional models. Here, I aim to identify the genetic or transcriptomic drivers of ITIH, and their impact on immune surveillance and control. I have recently developed an organoid – T-cell co-culture system that I will use to generate personalised models of ITIH. Leveraging the TRACERx lung cancer evolution study, I will establish multiple clonal organoid lines from the same tumour from NSCLC multi-region biopsies. Each organoid subline will be co-cultured with autologous T-cells to evaluate how they differ in sensitivity to T-cells. For each patient, the 6 most sensitive and 6 most resistant sublines will be used for DNA and RNA sequencing to identify mutations (including neo-antigens), copy number alterations and differentially expressed genes associated with resistance to T-cells. Candidate subclonal immune evasion factors will be validated in organoids by CRISPR-Cas9. I will prioritise genes by cross-referencing with genes associated with immune-cold regions in the TRACERx cohort. I will also perform pooled enrichment screens as a less biased approach.The integration of novel organoid technology with ‘big data’ from TRACERx allows moving beyond merely descriptive studies of ITIH. This will result in the most fine-grained mechanistic study of ITIH to date.


**Keywords:** organoids,  non-small cell lung cancer,  tumour heterogeneity,  TRACERx,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improving competitiveness of SMES through business engineering' under Fourth Framework.

assistant: **Concept**

The main objective of the project is to develop a methodology of work which can be used (and reused) by industrial policy makers to match SMEs' needs and IT solutions, in order to facilitate the organisation of Technology Transfer (TT) actions. The project aims to design, test apply and refine the COMPETE approach in the Esprit/TBP domain; it is targeted to a sample of SMEs in three European countries, and to the organisation of a number of effective and demonstrative TT pilot projects.The research work aims at identifying relevant indicators, allowing to select the SMEs as potentially recipients of IT applications, and a systematic analysis of IT solutions in order to create a portfolio of technologies and applications to be proposed. The approach is developed by merging the economic and technology expertise of partners operating in the economic and industrial systems analysis, and consultants specialists in IT-TBP.In order to be re-usable, the approach is defined in a way to be applicable independently from the specific geographic or technological areas in which it is tested in this project. While the typology of the core partnership is constant, the consultants vary according to the opted domain.The COMPETE results will be a guidebook to the preparation of TT actions in local areas, in a perspective going over the single business unit's horizon as well as the isolated IT result, and it will be supported by the outcome of the in-field experimentation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Co-operative research in information technology' (1994-1998).

assistant: **Concept**

The aims of the projects following the success of CRIT-1 pilot run in 1992 CRIT-2 is aiming at the main objective to stimulate a number of competitively selected Polish IT research sub projects to extend their links to research environments in the EU.The project is operated in two distinct phases. The main goal of phase 1 was to select highly innovative Polish sub projects. The evaluation process was organised and conducted by the consortium of partners under an advisory guidance of the panel of experts both from Poland and from the EU.The Polish Foundation of Science and the Polish Information Processing Society take the role of coordinating and monitoring the scientific work and they participate actively to run the administration of the project.16 Recommended sub project proposals (out of 30 proposals to the consortium) were submitted to the European Commission and are extending the project in phase 2. All selected sub projects are engaged in advanced research, their work has been recognised by EU peers, and the teams have established meaningful and mutually beneficial links with European research institutions. CRIT-2 fosters academic / industrial cooperation in the European IT field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transboundary Maritime Spatial Planning' (TRANSMASP).

assistant: **Concept**

From a public law and policy perspective, the TransMasp (Transboundary Maritime Spatial Planning) project will explore the impact of legal and natural boundaries in the implementation of Maritime Spatial Planning which is a tool to integrate sea use management. Despite of a strong request from International and European Union policy documents, transboundary aspects of Maritime Spatial Planning as well as its articulation with Land Spatial Planning are not yet scientifically handled. TransMasp will analyse a case study: the French-Belgian marine and coastal zone boundary (the Pas-de-Calais French region and the Belgian coastline). In this area, both countries share the same sandbanks, its rich biodiversity and substantial human activities (maritime transport, tourism, fisheries...). The case site is divided by the sea-land natural boundary and the French-Belgian legal boundary. Analysing it, TransMasp will investigate opportunities and constraints to develop a common Maritime Spatial Planning for a particular transboundary area. It will test the potential of Maritime Spatial Planning to ensure an effective ecosystem management across boundaries. Theoretically, this research work will further contribute to the understanding and development of the concept of Maritime Spatial Planning, its relation with Integrated Coastal Zone Management and Ecosystem Approach. It will combine those three theories in order to confront a fundamental question: how to keep sea use management coherent in a transboundary context?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'JTI-Clean Sky 1-Green Regional Aircraft-Integrated Technology Demonstrator', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

GRA - Green Regional Aircraft: Future green regional aircraft will have to meet demanding weight reduction, energy and aerodynamics efficiency, a high level of operative performance, in order to be compliant regards to pollutant emissions and noise generation levels. Objective of the Green Regional Aircraft ITD is to mature, validate and demonstrate the technologies best fitting the environmental goals set for the regional aircraft entering the market in the years 2015 - 2020. The project has 5 main domains of research, in which several new technologies are under investigation in order to entirely revisit the aircraft in all of its aspects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spatial ecology: bringing mathematical theory and data together' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The goal of my research plan is to make fundamental progress in the understanding of the ecological and evolutionary dynamics of populations inhabiting the heterogeneous and changing landscapes of the real world. To reach this goal, I will construct general and mathematically rigorous theories and develop novel statistical approaches linking the theories to data. In the mathematical part of the project, I will construct and analyze spatial and stochastic individual-based models formulated as spatiotemporal point processes. I have already made a methodological breakthrough by showing how such models can be analyzed in a mathematically rigorous manner. I plan to use and further develop the mathematical theory to study the interplay among endogenous and exogenous factors in spatial ecology, genetics, and evolution. To link the theory with data, I will develop novel combinations of forward (from process to pattern) and inverse (from pattern to process) approaches in the context of five empirical problems. First, I will build on the strong interaction between empirical studies and modelling in the Glanville fritillary butterfly to develop approaches that integrate genetics with ecology and evolutionary biology in highly fragmented landscapes. Second, I will investigate dead-wood dependent species as a model system of population dynamics in dynamic landscapes, bridging the current gap between data and theory in this system. Third, I will use existing data on butterflies, wolves and bears to study how animal movement depends on the interplay between landscape structure and movement behaviour and on intra- and interspecific interactions. Fourth, I will address fundamental questions in evolutionary quantitative genetics, e.g. the evolution of the matrix of additive genetic varia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Learning from Experience and Agency in Displacement (LEAD): Building a Refugee-led Approach to Displacement Justice'.

assistant: **Objectives**

Both in political and academic conversations, refugees are often spoken about but rarely spoken to. Refugees, of course, often discuss displacement justice with their own communities in response to their personal experiences and expertise, and with charities and agencies with whom they interact. But politicians, policymakers, and philosophers alike do not often have experience of displacement and fail to include those who do. Because of this, philosophers lack the resources to develop a fully comprehensive account of what justice for refugees might require. The LEAD project aims to critically develop the theoretical and methodological tools for a refugee-led approach to displacement justice. In recent years, literature in refugee studies and the ethics of migration has begun to reflect on refugee agency. This work highlights how displaced people respond to their difficult circumstances and emphasises the importance of choice and autonomy. This “agential turn”, which is present throughout social and political philosophy more widely, aims to centre the perspectives of marginalised groups. However, such work often stops short of including displaced people in the project of theory building itself. We can therefore ask: what would a refugee-led approach to theorising about displacement justice look like? The project will include people with experience of displacement not only in testing this methodology but also in critically building it throughout the research programme. The novelty of this project is three-fold. First, the LEAD project will integrate lessons from refugee and forced migration studies into the ethics and political philosophy of displacement. The project therefore attempts to build bridges between these two disparate literatures. Second, the project will radi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'voCAL articuLations Of Parliamentary Identity and Empire' (CALLIOPE), addressing dissemination and exploitation.

assistant: **Impact**

What did politicians sound like before they were on the radio and television? The fascination with politicians’ vocal characteristics and quirks is often connected to the rise of audio-visual media. But in the age of the printed press, political representatives also had to ‘speak well’ – without recourse to amplification.Historians and linguists have provided sophisticated understandings of the discursive and aesthetic aspects of politicians’ language, but have largely ignored the importance of the acoustic character of their speech. CALLIOPE studies how vocal performances in parliament have influenced the course of political careers and political decision making in the 19th century. It shows how politicians’ voices helped to define the diverse identities they articulated. In viewing parliament through the lens of audibility, the project offers a new perspective on political representation by reframing how authority was embodied (through performances that were heard, rather than seen). It does so for the Second Chamber in Britain and France, and in dialogue with ‘colonial’ modes of speech in Kolkata and Algiers, which, we argue, exerted considerable influence on European vocal culture.The project devises an innovative methodological approach to include the sound of the human voice in studies of the past that precede acoustic recording. Adapting methods developed in sound studies and combining them with the tools of political history, the project proposes a new way to analyse parliamentary reporting, while also drawing on a variety of sources that are rarely connected to the history of politics.The main source material for the study comprise transcripts of parliamentary speech (official reports and renditions by journalists). However, the project also mobilizes education