RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Industry 4.0 Enhanced Digital Product Passports and Circular Economy Dataspaces for Sustainable Bio-Based Industries'.

assistant: **Concept**

The digital and circular economy (CE) transition of bio-based industries is a critical objective for Europe’s climate ambitions and its economic competitiveness. Given the urgency of these demands, Europe’s bio-based industries need to leapfrog over past digital technologies and implementations, pioneering innovative solutions for creating bio-based products and services that are circular, as well as environmentally and socially sustainable.  To realise these ambitions, the bi0SpaCE project will deliver a suite of technologies, services, guidance frameworks, and standards, combined into the open-access bi0S platform, for rapid deployment and scaling of (CE) solutions and services across bio-based industries and their value chains. bi0SpaCE will advance the creation and implementation of Industry 4.0 enhanced Digital Product Passports (DPPs), linked to an International Dataspace (IDS) compliant CE dataspace, enabling the creation of dynamic and decentralised DPPs for secure and trustworthy sharing of CE and sustainability performance data of bio-based products across the value chain, as well as providing transparency of green and CE claims to consumers. bi0SpaCE brings together a consortium consisting of 1 HEI, 4 RTOs, 1 SMEs, 1 industrial assoc., 2 large industries, and 1 startup, across 5 EU and 2 associated countries, over a 36-month project period.  The knowledge and technologies created in bi0SpaCE will be demonstrated and validated across 4 complementary bio-based sectors: (i) paperboard production, (ii) eco-industrial parks with bio-based energy and products producers and consumers, (iii) plant-based products and cosmetics, and (iv) bio-derived industrial chemicals.


**Keywords:** Digital Product Passports, Digital Twins, Data Spaces
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Producing a shared vision on how to harness Research & Development for Sustainable Development'.

assistant: **Innovation**

The main objective of VISION RD4SD is to ensure that Europe is able to contribute to a Sustainable Development of the world by formulating policies and decisions based on robust, up to date knowledge of highest scientific quality.The project focuses on a dialogue among European science policy-makers, administrators and those funding-policy makers in general who demand and need solutions from VISION RD4SD.The project will develop an overview of how research and development to support a sustainable development is being funded, supported and evaluated by science policy. This will be done by a number of state of the art studies. These studies will be carried out through desk research and interviews, on country, regional and European scale. The dialogue process will consist of a set of facilitated workshops. The results of these workshops will be synthesised in a shared vision of how to harness Research & Development for Sustainable Development.The final step of the project will disseminate the results to a broader target group in science policy as well as science communities working in support of Sustainable Development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanism of DNA-protein cross-link repair in S phase' (2014-2020).

assistant: **Innovation**

DNA-protein cross-links (DPCs) are common DNA lesions caused by endogenous, environmental, and chemotherapeutic agents. Cells are susceptible to these lesions during S phase, as DPCs impede replication fork progression and are likely to induce genomic instability, a cause of cancer and aging. Despite its relevance to human health, the repair of DPCs is poorly understood. Research on DPC repair has mainly involved testing cellular responses to compounds such as formaldehyde, but these agents induce a wide variety of DNA lesions, and conflicting results have been reported. To overcome these obstacles, I have developed the first in vitro system that recapitulates replication-coupled DPC repair. In this system, a plasmid containing a site-specific DPC is replicated in Xenopus egg extracts. Using this approach, I demonstrated that DPC repair requires DNA replication. When a replication fork encounters a DPC, the DPC is degraded into a peptide-adduct, which allows replication bypass by translesion DNA synthesis. Importantly, these experiments identified a novel proteolytic pathway whose activity is regulated by replication. This in vitro system now provides a powerful means to identify and characterize the different factors that participate in S phase DPC repair. I speculate that for DPC processing to occur, the protein-adduct must first be detected, then marked for degradation and ultimately degraded. Using a series of complementary strategies, which will take advantage of the in vitro system combined with proteome and genome wide approaches, I seek to uncover the different players that participate in each of these events. This project will enable a detailed mechanistic outlook of a complex multi-step reaction that has not been feasible to achieve using existing methodologie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Evaluation of Novel Ultra-Fast selective III-V Epitaxy'.

assistant: **Innovation**

As the worldwide photonics market is increasing and optical and electronic devices based on III-V semiconductors are gaining market segment, the production of III-V semiconductor wafers including GaN has increased in volume  and sizes have increased from 2” to 6”. However, this is still short of the 8”-12” common in Silicon CMOS technology. Furthermore, the integration of III-Vs on silicon or on-insulator, has been a long-standing goal for the past 50 years, in order to combine electronic and photonic applications, and to allow photonic technologies to take advantage of the highly developed silicon CMOS technology, thereby opening up for vast new application opportunities. The aim of ENUF is for the first time to attempt to combine two different growth methods to achieve a low-cost integration of large-area III-V on insulator on a silicon platform, and to establish this as a replacement technology for existing III-V wafer production or to enable low-cost integration of optically active material as enabling technology for silicon photonic applications. The method can also be adapted to GaN on Si or on insulator for low-cost high-volume production of high power electronics and light emitting devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RESPONSIBLE RESEARCH AND INNOVATION APPROACH FOR TRANSITIONING THE TRADITIONAL INDUSTRY REGIONS INTO DIGITALISED INDUSTRY TERRITORIES.' under Horizon 2020.

assistant: **Concept**

The project develops a framework for a responsible transition of traditional industry regions into digitalised industry R&I ecosystems. The elaboration of this framework will be performed together with the impacted industries, the influential territorial authorities, and the affected citizens. The creation of strategies and a concept will be conducted for implementing resilient R&I ecosystems for digitalised industries in traditional industry territories. Resilient R&I ecosystems requires taking into account a high degree of openness, democratic accountability, and responsiveness to the needs of the addressed industries and society in the considered regions.


**Keywords:** self-sustaining R&I ecosystems,  transitioning traditional regions into digitalised industrial territories,  regional development,  Värmland (SE),  Région Grand Est (FR),  Styria (AT)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural Transformation to Attain Responsible BIOSciences' (2014-2020).

assistant: **Concept**

STAR BIOS 2 (Structural Transformation to Attain Responsible BIOSciences),coordinated by the University of Tor Vergata (IT), has been designed to respond to the Topic ISSI 5 (Workprogramme Science With And For Society). The general aim of project is that of contributing to the advancement of the Responsible Research and Innovation (RRI) strategy, whichunderpins Horizon 2020, by promoting 6 Action Plans (APs) oriented to attain a RRI structural change in research institutions from Europe and developing 3 further APs in non-european entities, all active in the field of biosciences.This strategy is geared to cope more in general with one of the main risk, for European research, i.e., its inadequate connection with society, by promoting its increasing alignment, in terms of both process and outcomes, with the needs and values of European society. This entails, in the RRI perspective, an increasing involvement of stakeholders at any level of the research and innovation process.The project has three main focuses:1) Develop RRI-oriented structural change processes in the already mentioned institutions involved in biosciences research. This aim will be pursued through designing, implementing and evaluating RRI Action Plans. In order to secure the results emerging from the APs, a sustainability strategy will be developed and implemented during the project lifespan.APs will be supported by a central technical assistance and the project will be monitored and assessed.2) Develop a learning process concerning: a) resistances and barriers to RRI (which are they, how they manifest themselves, which impact they have, etc.); b) key factors favouring or supporting RRI; c) strategic options and RRI-oriented tools.3) Develop a sustainable model for RRI in biosciences.


**Keywords:** Struc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Innovative therapeutic tools to ameliorate chemotherapy-induced cardiotoxicity'.

assistant: **Objectives**

p38_InTh aims at improving the potency of a new class of highly specific p38 pathway inhibitors and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity of the chemotherapeutic. Chemotherapeutics used for cancer treatments have serious side effects, both the most broad-spectrum ones (such as anthracyclines) and the directed ones (such as trastuzumab). In particular, the cardiotoxicity is a major issue associated to chemotherapy. Cardiooncology research has recently emerged to tackle this serious unmet medical need.  The cardiotoxicity induced by chemotherapeutics includes from arrhythmia to heart failure. To mitigate it, cardiooncologists usually adjust the treatment with reduced doses for a longer period, but this makes the anticancer treatments less efficient and consequently reduces the quality of life of the patients. There is evidence that cardiomyocyte death induced by anthracyclines involves activation of a specific p38 pathway, suggesting that inhibition of this pathway may reduce the cardiotoxicity associated with chemotherapeutics.  Over the last two decades, many p38 pathway inhibitors have been developed by industry. However, these are mostly ATP competitors and have shown disappointing results in clinical trials. In contrast, we have recently identified novel compounds that inhibit only one of the target isoforms and through a novel MoA, selectively antagonizing the activation of this isoform by one of its protein partners. We propose to improve the potency of these hits and validate their potential therapeutic use to ameliorate chemotherapy-induced cardiotoxicity without affecting the cancer cell toxicity. Importantly, our new drug would inhibit only a subset of the p38 pathwa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Services enhancing the innovation management capacity of SME's and Key Account Management in Niedersachsen'.

assistant: **Innovation**

EEN Niedersachsen Enterprise Europe Network Enhancement  Innovation Management Capacities of SMEs and Key Account Management for SMEs.To achieve the above mentioned objectives the Network partners will:1. Increase the efficiency and effectiveness of innovation processes in small and medium sized enterprises with significant innovation activities that could potentially become beneficiaries of European support programmes for research and Innovation, but do not have sufficient access to consulting services for innovation management. This service, provided independently from a specific innovation project and focusing on a company's innovation management system, is called Enhancing the innovation management capacity of SMEs (EIMC). • Partners will deliver minimum 27 EIMC actions as described in Work package 1 as 7-10-day-packages2. Identify bottlenecks in the creation of economic impact in companies benefitting from grants under Horizon2020's SME instrument and address these bottlenecks with the help of capable coaches. This service to beneficiaries of the SME instrument in the context of a given project is called 'Key Account Management'. Partner NBank will provide this service to all companies successful in their proposals in the funding schemes SME Instrument, Fast Track to Innovation and Future and Emerging Technologies Open.  • Partner NBank plans to deliver 8 Key Account Management actions as described in Work package 2 as 7-day-packages related to successful proposals for the mentioned funding schemes from the region.


**Keywords:** EIMC, Key Account Management, Niedersachsen, Innovation Management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Geothermal Energy in Special Underground Structures' (GeoUS), addressing dissemination and exploitation.

assistant: **Impact**

GeoUS will support increased research excellence in geothermal energy at VSB -Technical University of Ostrava, Czech Republic through close cooperation with Fraunhofer Institute, Germany and University of Vaasa, Finland. The ultimate goal is the development of multi-disciplinary research and innovation skills in the Czech Republic, focused on the fundamental and practical aspects of developing geothermal as a sustainable energy source. GeoUS will enable VSB to expand its network with  leading research organisations in geothermal energy. It also involves young researchers to support future development of research activities impacting in the Moravia Region in line with the Regional and National Research and Innovation Strategy for Smart Specialization (RIS3 Strategy) and ESIF targets. The results will be widely shared with City Authority of Ostrava, Moravian-Silesian Regional Authority and also with authorities at national level.GeoUS will: 1. Transfer knowledge and build excellent research.2. Increase scientific excellence in thermal characterization and mathematical modelling of heat flows and temperature fields and in measurement and control of energy flows.3. Improve the scientific excellence and research capacity of VSB.4. Increase the capacity of VSB for participation in future high-quality research activities and innovation in thermal energy in Central Europe.5. Increase the interaction with and between the main players in the innovation process in Czech Republic for developing and exploiting geothermal energy.6. Widen the visibility of VSB as a centre of excellence for thermal energy.7. Engage with the public and citizens and young people on science related to thermal energy.


**Keywords:** geothermal energy, heat exchangers, heat storages, capacity building
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Deciphering causes and consequences of inflammation in subtypes of sporadic intestinal cancer'.

assistant: **Objectives**

An association between inflammation and carcinogenesis is well established, however, how they are related mechanistically in subtypes of sporadic intestinal tumours remains unclear. This study aims to decipher how oncogenes determine the inflammatory microenvironment (stroma) and how this affects tumour development and survival. Notably, intestinal epithelium-specific expression of oncogenic Kras(G12D), Braf(V637E) and Pik3ca(H1047R) in mice mimics serrated intestinal cancers in humans faithfully. Preliminary data suggest that the mutational make-up of the tumour may dictate the pro- and anti-tumourigenic immune response, which in turn determines tumour development and survival. This study therefore aims to characterise the tumour-infiltrating immune cells by systematic immunophenotyping and to decipher the involved inflammatory signalling mechanisms in a cell-type and mutation-specific manner. Moreover, we aim to reconstruct the formation of the oncogene-specific inflammatory microenvironment, which we will determine via endoscopic transplantation of intestinal organoids derived from Kras(G12D), Braf(V637E) and Pik3ca(H1047R) mice into the large intestine of wild-type mice. Importantly, detection of involved inflammatory mediators and immune cell-subtypes will allow us to genetically target them in vivo using novel in-house generated dual-recombinase systems (DRS). In order to investigate the consequences of inflammation on sporadic intestinal tumourigenesis, models with genetically or experimentally induced chronic inflammation will be applied. Conversely, immunodeficient Rag2;Il2rg–/– mice will be used to elucidate if sporadic intestinal carcinogenesis in Kras(G12D), Braf(V637E) and Pik3ca(H1047R) mice is dependent on inflammation and can be abrogated. This study wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Coming to Terms: Proof Theory Extended to Definite Descriptions and other Terms' (ExtenDD).

assistant: **Concept**

The project is concerned with two areas which so far have rarely come together: complex terms and proof theory. ExtenDD focuses on definite descriptions as the most important and troublesome singular terms and on sequent calculus and its generalizations as the most important tool of modern proof theory. Since Russell's 'On Denoting', regarded as a paradigm of analytic philosophy, definite descriptions occupy a central place in philosophical research and many deep and detailed studies have been carried out. The second half of the 20th century saw the development of new approaches to this phenomenon based on non-classical logics, in particular free logic in which, contrary to Frege's and Russell's classical logic, it is not assumed that every term refers. Yet despite the long history of research into definite descriptions, a paradigm of formal logic has so far rarely been applied to them: proof theory. The methods developed by Gentzen, in particular those relating to his sequent calculus, provide the means for the deepest study of proofs and their properties. Yet only a small effort has so far been put into the adequate treatment of definite descriptions in this framework. The same counts for other complex singular terms such as set abstracts and number operators. ExtenDD fills this important gap in research. Applying the methods of proof theory to definite descriptions is profitable to both sides. Competing theories of definite descriptions and complex terms in general, their advantages and shortcomings, are shown in a new light. The behaviour of complex terms needs subtle syntactical analysis and requires enriching the toolkit of proof theory. ExtenDD deals with both challenges: it develops formal theories of definite descriptions and modifies the machinery of proof the