RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The transcription-related DNA damage response' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The cellular response to bulky DNA lesions, such as those induced by UV-irradiation, remains enigmatic despite decades of study. The effect of such damage on transcription is complex. At the local level, lesions cause stalling of RNAPII, resulting in a block to transcript elongation. Stalled RNAPII triggers transcription-coupled nucleotide excision repair, a process whereby lesions in genes are preferentially removed. Importantly, however, UV-irradiation also affects transcription genome-wide, so that even genes that are not damaged temporarily cease to be expressed. Alternative mRNA splicing also changes dramatically. The mechanisms and factors that underlie the global, damage-induced changes in gene expression, and its eventual normalization, are poorly understood. In order to facilitate identification of new factors and mechanisms involved in this response, we performed several distinct proteomic screens and an siRNA screen in parallel. This was complemented by characterization of transcription and mRNA splicing after DNA damage by genome-wide techniques. Any screening for new factors is high-risk, and the decision on which ‘hits’ to pursue is always difficult. Indeed, in any individual proteomic or genomic screen it is often impossible to distinguish ‘real’ hits from hundreds, if not thousands, of false-positives, and false-negative results are very frequent as well. Our multi-omic approach explores the same process from various angles and places less emphasis on hits from an individual screen and instead focuses on factors that score in several screens. This integration of screen results has resulted in the identification of several new factors and unexplored mechanisms. With a basis in exciting preliminary findings, this grant proposal thus describes a multi-disci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Effective Perinatal Intensive Care in Europe: translating knowledge into evidence based practice' (EPICE), addressing dissemination and exploitation.

assistant: **Impact**

Context: Very preterm infants face high risks of mortality and long-term neuro-developmental impairment. Rates of mortality and morbidity vary by a factor greater than two between European regions. This project’s overriding aim is to improve these infants’ survival and long-term health and development by ensuring that available medical knowledge is translated into effective perinatal care.Objectives: (1) Build an empirical knowledge base concerning how scientific evidence is translated into health service provision in maternity and neonatal units by measuring the use of key medical interventions in clinical settings, identifying the factors associated with adoption of evidence-based practices and providing updated information on the effectiveness of medical practices; (2) Assess decision-making and knowledge implementation processes within units and regions to identify catalysts for evidence-based practice; and (3) Propose intervention strategies to achieve behavioural change.Study design: This project combines quantitative and qualitative approaches to assess the use of evidence-based medical interventions and determinants of use on the regional, unit and patient level in 19 European regions (≈550 units, ≈ 10,500 births). The project includes a population-based cohort study of very preterm infants with follow-up to 2 years of age, a survey of all maternity and neonatal units caring for these infants, semi-structured narrative interviews and focus groups in selected units and case studies on regional governance.Impact: The project will produce empirical data about the uptake of medical interventions in European maternity and neonatal units and new knowledge about catalysts for the adoption of medical knowledge. Its results will provide a methodological and conceptual ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Art and Ethics: Restarting and Advancing a Stalled Debate' under Horizon 2020.

assistant: **Concept**

This project is a work of philosophy that investigates how intrinsic ethical properties are realized in artworks and other aesthetic and creative objects and practices, and in what respects their aesthetic values are determined by these properties. The project innovates in three principal ways. First, it identifies and articulates novel ways by which artworks and similar objects and practices come to exhibit ethical properties, where the existing literature in this area relies exclusively on just one way this can occur. Second, it diagnoses why the literature on the question of ethico-aesthetic value interaction has stagnated for almost a decade, by revealing the vague and inconsistent conceptual tools on which its theorists have relied until now, and which have inhibited its progress. Finally, it uses the preceding two innovations to articulate a new and satisfactory theory about how ethical properties determine aesthetic values.The project promises to radically transform a live, if currently inert, philosophical literature while offering a comprehensive strategy to share its interdisciplinary and public interest benefits with stakeholders beyond philosophy and indeed the academy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Roadmap Enabling Vision and Strategy for ICT-enabled Energy Efficiency' in the context of a Seventh Framework call.

assistant: **Objectives**

REViSITE will contribute to the formation of a European multidisciplinary 'ICT for energy-efficiency' research community by bringing together the ICT community and 4 important and complementary application sectors: grids, building/construction, manufacturing and lighting.The objectives of REViSITE are to: (1) Establish communication between sectoral ICT4EE communities in the 4 key industrial domains; (2) Develop causal model on the impacts of ICT on energy efficiency and apply this methodology for identifying high-impact RTD priorities; (3) Develop a cross-sectoral RTD roadmap by identifying and harmonising common topics; (4) Promote interoperability and standards; (5) Awareness raising.The main activities of the workplan are: (1) Community consolidation; (2) Identification of RTD priorities based on impact assessment; (3) Multi-disciplinary RTD roadmap for ICT-enabled energy efficiency; (4) Dissemination and awareness-raising.The consortium consists of 7 patners from 7 countries with wide geographic coverage of EU. Participants are active players in the 4 domains and the related European Technology Platforms, notably: Artemis, ECTP, ManuFuture, Photonics21 and SmartGrids.Through dissemination and awareness-raising activities, REViSITE aims at creating the following impacts: (1) Multidiciplinary European ICT4EE community;(2) Rational selection of priorities for RTD on ICT4EE;(3) European ICT4EE research agenda;(4) Convergence of ICT standards across sectors;(5) ICT4EE as a cross-discipline path in education and training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improvement of Innovation Management Capacity of SMEs from Bosnia and Herzegovina (FBH) through the Enterprise Europe Network' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A single network of excellence will be created covering territory of Federation of Bosnia and Herzegovina (hereinafter FB&H) implementing “no-wrong door” concept. This Network (Business, Innovation and Technology Network-BITNET) will build on the results of the Business Information and Technology Innovation Network-BITIN that has been successfully operating  since 2009 offering integrated services in support to business and innovation. The partners agreed to work together within the Enterprise Europe Network 2017-2020 offering to their clients a variety of the Network services. This Network will be a member of the Enterprise Europe Network giving its contribution to increased competitiveness of FB&H (B&H) and EU companies. The network of competent and proficient partners will implement the project.Consortium partners are: The Foreign Trade Chamber of Bosnia and Herzegovina (FTC), located in Sarajevo (FTC)- coordinator; Sarajevo Economic Region Development Agency (SERDA) located in Sarajevo, University of Sarajevo (UNSA) located in Sarajevo, INTERA Technology Park (INTERA) located in Mostar, Zenica Economic Development Agency (ZEDA) located in Zenica, BIT Centre (BIT) located in Tuzla and Development Agency of the Una-Sana Canton (DAUSC) located in Bihać. All the partners are strategically chosen and positioned in FB&H, namely the cities are the main centres of economic activities in FB&H and most of SMEs are concentrated around these cities.The Consortium partners that will be delivering Key Account Management (KAM) services and services to enhance the innovation management capacity of SMEs, within the project, will be UNSA, INTERA and BIT. All these activities will support SMEs on their way of becoming more competitive internationally.


**Keywords:** Technology develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Controlled Degradable Polymer Carriers for mRNA Vaccination: From Pathogens to Personalized Cancer Immunotherapy'.

assistant: **Concept**

The tragic outbreak of the COVID-19 pandemic stimulated research to go beyond common grounds and develop powerful vaccines against the SARS-CoV-2 virus. A new vaccine technology based on messenger RNA (mRNA) was translated into almost one billion patients and saved millions of lives. It addresses the needs of rapid, scalable and adaptable vaccine production. However, mRNAs require potent nanocarriers to prevent the RNA strands from extracellular degradation and enable their uptake into antigen-presenting cells. During urgent development, established lipid-based nanoparticles (LNPs) were used for mRNA encapsulation, yet, they provided limited long-term stability and required strict temperature storages, which prevented their distribution to locations with no cold storage options. Moreover, several patients experienced hard-to-control immunological adverse effects that were associated with some of the lipid components.In my ERC proposal, I therefore want to pioneer a novel and unprecedented macromolecular approach that will overcome these issues and introduce polymer-based and lipid-free, lyophilizable nanocarriers for intelligent mRNA delivery. I will generate self-immolative poly(carbonate)s with reductive decationizable features for controlled RNA complexation, as well as stimuli-responsive release and carrier depolymerization upon entry into antigen-presenting cells. Co-delivery of small molecule immune modulators will enable precise control over quality and quantity of the pursued humoral and cellular immune responses. Moreover, reversible core-crosslinking and surface conjugation with relevant targeting units will foster systemic in vivo applications towards immunization against infectious diseases and cancer.Elaborating multi-responsive macromolecular tools on an m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gliders for Research, Ocean Observations and Management: Infrastructure and Innovation' (2014-2020).

assistant: **Concept**

Underwater and surface drones, in particular gliders, have become essential vehicles to carry scientific payloads for most environmental observations from the surface down to 6000m and for activities supporting the blue economy. Their major advantages are being mobile, steerable, persistent and usable in large numbers and at relatively low costs. However, the distributed infrastructure required to exploit these assets must be able to meet different demands from research and monitoring of the marine environment, to public service missions and industry needs, requiring customised payloads and operations. The rapid evolution of such technologies (robotics, artificial intelligence, sensors, big data) requires that the R&D resources offered by this distributed infrastructure continuously adapt to users’ demands. The complex hardware and information technology characteristics of such a distributed European infrastructure, optimizing access to resources and R & D for gliders, were analysed during the GROOM-FP7 design study from the perspective of research and the Global and (future) European Ocean Observing System (GOOS & EOOS) needs. Since then, several “gliderports” have developed which has fostered a corresponding European industrial innovative sector. GROOM II, building on its predecessor, will deliver the decision basis for an advanced MRI that promotes scientific excellence, fosters innovation, support the blue economy, builds industrial and public partnerships, and works towards helping achieve the common research and innovation mission for future Europe. The project will define the overall organization of an infrastructure dedicated to ocean research and innovation, and maritime services supporting Blue Growth. This infrastructure will be a positive step against today’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced gate stacks for CMOS technology' (ACT).

assistant: **Innovation**

We will explore advanced gate stacks for ultimate scaling of silicon based devices beyond the 45nm technology node. The firstobjective will be to find suitable metal oxide dielectric materials to replace the long standing silicon dioxide from the transisto rgate. The materials must have a dielectric constant higher than 30 and a high thermal stability in contact with silicon, in orderto obtain equivalent oxide thickness (EOT) 0.5nm or lower. The second objective will be to develop appropriate models for thea nalysis of the electrical data in order to extract accurate values of EOT, interface trap density, and flat band voltage shifts. Toachieve the objectives we have broken our workplan in four priorities which are: materials preparation; post-depositiontreatm ent; device fabrication and testing; data analysis. To implement the workplan we are going to exchange scientistsbetween the academic institution NCSR-'Demokritos' and the industrial organization Philips Research Leuven. Philips willlearn from Demokritos" about non-traditional material preparation methodologies based on molecular beam epitaxy(deposition) and structural characterization of metal oxides and interfaces. On the other hand NCSR will learn from Philipsabout fabrication and electrical testing of high-k devices. The immense interest of the industry in exploring new materials andassociated equipment at a low cost without disrupting the main process flow, guarantees that this collaboration will developinto a lasting strategic partnership."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Data Engineering for Data Science' (DEDS).

assistant: **Concept**

Data is a key asset in modern society. Data Science, which focuses on deriving valuable insight and knowledge from raw data, is indispensable for any economic, governmental, and scientific activity. Data Engineering provides the data ecosystem (i.e., data management pipelines, tools and services) that makes Data Science possible.The European Joint Doctorate in Data Engineering for Data Science (DEDS) will develop education, research, and innovation at the intersection of Data Science and Data Engineering.  The objective is to provide holistic support for the end-to-end management of the full lifecycle of data, from capture to exploitation by data scientists. DEDS is the only doctoral programme worldwide with this focus, which is crucial for realizing the next generation of Data Science breakthroughs.DEDS is jointly organised by Université Libre de Bruxelles (Belgium), Universitat Politècnica de Catalunya (Spain), Aalborg Universitet (Denmark), and the Athena Research and Innovation Institute (Greece). Partner organisations from research, industry and the public sector prominently contribute to the programme by training students and providing secondments in a wide range of domains including Energy, Finance, Health, Transport, and Customer Relationship and Support.DEDS is a 3-year doctoral programme based on a co-tutelle model. A complementary set of joint doctoral projects focus on the main aspects of holistic management of the full data lifecycle. Each doctoral project is co-supervised by two beneficiaries and includes a secondment in a partner organisation, which grounds the research in practice and validate the proposed solutions.  DEDS delivers innovative training comprising technical and transversal courses, four jointly organized summer and winter schools, as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Commercialization of TREG cells sorting and proliferation in vitro for the production of vaccines for the treatment of type 1 diabetes.' under Horizon 2020.

assistant: **Concept**

The applicant aims at delivering economically sustainable and innovative cell therapy dedicated to the treatment of DM1 with the use of TREGs vaccine. The TREG therapy, covers almost all aspects listed in the call, i.e. cell identification, sorting, culture, multiplication (all 4 steps covered in patent), banking, transport, delivery (running clinical trial) and strict quality control. The project’s objective is to increase the commercial success of the therapy while making it economically effective to the payer (state, local government, national health funds/insurance). The project’s outcome will be an innovative model for treatment of highly devastating disease even with the possibility of preventing highly undesirable side effects for a patient and on a macro-scale for the economy, society and pension scheme. However, in scaling-up, the Company has to identify regulatory pathways to abide even when the technology is out of scope of current regulatory landscape. New therapy means also identification of new business models. Reaching market authorization will be determined on the basis of acceptance of currently carried out academic clinical trials and any further clinical trials ordered by the EMA. Elaboration of feasibility study will allow PolTREG to prepare the necessary strategy for this regulatory requirements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mental Health Promotion and Intervention in Occupational Settings: MENTUPP' (MENTUPP).

assistant: **Concept**

Depression and anxiety are the most prevalent mental health difficulties in the workplace in the EU, causing immense suffering and costing the global economy €1 trillion each year in lost productivity. Certain sectors, in particular construction, health and ICT, have an elevated risk of mental health difficulties, with those working in Small and Medium Enterprises (SMEs) being particularly vulnerable. However, most SMEs have limited capacity to address mental health promotion and provide mental health interventions to staff. As SMEs comprise more than 90% of all EU businesses, there is a huge potential to influence population health. MENTUPP aims to improve mental health and wellbeing in the workplace by developing, implementing and evaluating a comprehensive, multilevel intervention targeting both clinical (depressive, anxiety disorders) and non-clinical (stress, burnout, wellbeing, depressive symptoms) mental health issues, as well as combating the stigma of mental (ill-) health. The intervention will be tailored for SMEs in construction, healthcare and ICT and assessed in a multi-country Cluster Randomised Controlled Trial. The primary aim is to improve mental health in the workplace, with a secondary aim to reduce depression and suicidal behaviour.MENTUPP will be conducted by an interdisciplinary consortium that includes world leading experts in mental health in occupational settings, depression, anxiety, stress, suicide prevention and stigma. It builds on a solid foundation of evidence, in particular leveraging partner European Alliance Against Depression’s four-level intervention to improve mental health and reduce suicide risk and partner Mates in Construction’s successful workplace intervention to reduce suicide in construction workers. Long-lasting impact is al