RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Integrated tool for in situ characterization of effectiveness and durability of conservation techniques in historical structures'.

assistant: **Innovation**

The European Cultural Heritage deals with a great variety of structures of high intrinsic value. Among these are the stones the key elements of our monuments. However, it has become clear that in contemporary urban environment deterioration of untreated and consolidated stones occurs at an alarming rate. Damage diagnosis of stones is the first stage in the planning of the remedial steps to which the success of the restoration will be entrusted. Till now there is not available in the market a valid stone-friendly" procedure for the in site assessment of effectiveness and durability of stone consolidation. The main Project goal is to develop this technology through the design, construction and validation of an integrated portable tool (DIAS). The components of this tool are special micro drilling, indentation and acoustic devices and system management software."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Anti-receptor autoantibodies in cardiovascular diseases. Diagnostic and therapeutic implications' to be submitted under Fourth Framework.

assistant: **Abstract**

- To define the immunogenic background of` the autoimmune response against G protein coupled cardiovascular receptors.- To define whether these autoantibodies only reflect all autoimmune status or are responsible for the pathogeny of the disease.- To define the in vivo effect of functionally active polyclonal and monoclonal antibodies.In several cardiovascular diseases (idiopathic dilated cardiomyopathy,secondary malignant hypertension) the presence has been detected of autoantibodies against cardiovascular receptors belonging to the superfamily of G protein coupled receptors. These autoantibodies have been shown to exert an agonist-like activity on the target receptors in the absence of desensitization. Although the functional properties of these autoantibodies could be of importance in the pathogenesis and/or the development of the diseases in which they are found, there is no direct evidence for this hypothesis. In order to answer this question, a more thorough characterization of thecellular and humoral components of the autoimmune response will be performed focusing on the structural recognition at the T cell level (determination of HLA class II molecules related to the presence of these autoantibodies and using peptides derived from the receptors to study their interaction with HLA molecules) and the B cell level (determination of the structure of the B cell epitopes recognized by the functional autoantibodies or by polyclonal and monoclonal antibodies against the target peptides). The receptors studied will be the beta 1- and beta 2-adrenergic receptor, the M2 acetylcholine, the (1-adrenergic, the AT1 angiotensin and the B2 bradykinin receptor.  The polyclonal and monoclonal anti-receptor antibodies will be studied for their pharmacological, biochemical and physi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Observing Unique sTars and gaLactic chemIcal Evidence of the fiRst relicS' (OUTLIERS).

assistant: **Concept**

The number of identified primitive low-metallicity stars has steadily grown. Today, we know of stars with less than one ten-millionth of the solar iron content, but no stars completely devoid of metals —known as Population III (Pop III)— have been identified so far. It was commonly accepted that only massive, short-lived Pop III stars formed from metal-free clouds, but recent simulations suggest that their low-mass counterparts (<1M☉) could also form and may still survive today. However, the mass distribution of these first stars remains unknown, though most are expected to be massive, reaching up to 1000M☉. The first supernova (SN) enriched the medium with heavy elements, enabling the formation of long-lived Population II (Pop II) stars from this processed material. These stars exhibit distinct chemical peculiarities that are key to understanding their Pop III progenitors, including mass and SN explosion energy. However, identifying and characterising these exceedingly rare chemically peculiar stars poses significant challenges. Finding long-lived Pop III stars or second-generation stars polluted by very massive Pop III SNe will revolutionise modern astronomy.With OUTLIERS I propose a novel approach that combines an unprecedented observational effort, encompassing my large program with the 10.4m GTC, privileged access to the latest spectroscopic surveys (DESI, 4MOST, WEAVE), and Gaia BP/RP data. Together with state-of-the-art models and my advanced analysis tools (FESWI, PISN-explorer), this approach will increase the number of chemically peculiar stars by over an order of magnitude, allowing us, for the first time, to:-Search for Pop III stars within the largest spectroscopic dataset ever compiled-Identify and characterise second-generation stars to reconstruct the ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Fluid Silicates at Extreme Conditions and the Magma Ocean'.

assistant: **Innovation**

Partial melting of silicates dominates the chemical evolution of Earth today and was even more important in Earth’s earlier history.  The Earth may have begun in a completely molten state, a global magma ocean, with silicate liquid extending from a dense silicate atmosphere to the boundary with the iron-rich core at a pressure of 140 GPa.  Deep melt may exist in the Earth today, and the magma ocean may have left signatures of its presence.  However, these signals are still uninterpretable because of a lack of basic knowledge of the behavior of fluid silicates at extreme conditions: very little is known of the physics and chemistry of fluid silicates beyond the conditions of ongoing shallow magma genesis (<3 GPa).  We propose to solve this problem by constructing a comprehensive thermodynamic model (HeFESTo) of multi-component silicate melting, vaporization, and reaction with iron, and the physical properties of liquid and vapor phases over the entire pressure-temperature range relevant to Earth, including impacts and early Earth processes.  To help constrain the thermodynamic model, we will perform new first principles quantum mechanical simulations in the range of pressure, temperature, composition relevant to the early Earth that have not yet been explored by experiment or theory.  Simulations will include key homogeneous and heterogeneous systems of fluid silicates in liquid, vapor, supercritical, and solid forms, including simulations of pure phases, and phase coexistence.  We expect HeFESTo to change our views of magma ocean evolution and lead to new scenarios of Earth’s earliest evolution.  What these scenarios might be is impossible to predict as they will be shaped by still unknown aspects of the physics and chemistry of silicate liquids at extreme conditions, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Armed Conflicts, Peacekeeping, Transitional Justice: Law as Solution' (ATLAS).

assistant: **Innovation**

The cooperative project ATLAS responds to this call by examining the role and impact of the rule of law and international humanitarian law applicable during armed conflict with regard to effectively promoting and protecting human rights. From a prospective standpoint, normative weaknesses and gaps must first be pinpointed. The operational dichotomy between proclaiming a right and assuring its effective respect must lead to proposing rules designed specifically to assure greater effectiveness of the existing legal framework by taking into account the concrete realities of violations of international human rights and humanitarian law. Due to the non traditional configuration of contemporary conflicts and the diversification of the actors implicated therein, violations of international human rights and humanitarian law have taken on new forms. Either the existing legal framework must be strengthened, or new legal responses must be developed. The overall objective of this study is to determine how the EU may contribute to promoting human rights and international humanitarian law both during and after armed conflicts. In this context, ATLAS will compare existing international legal rules with the practice of both Member states and third states in order to support decision-making by decision-makers. The Member states that have been chosen (France, Romania, Spain and the United Kingdom) represent both the Roman-Germanic and common law legal traditions and the diversity of national practices among Member states. The third states/region that have been selected are Cambodia, the former Yugoslavia (Bosnia and Kosovo), Haiti and Sierra Leone. These areas were chosen according to two principles: their experience with peace operations and the existence of national reconciliation proc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Epidemiology and ecology of enterococci, with special reference to antibiotic resistant strains, in animals, humans and the environment' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Background: Enterococci are bacteria that are normal inhabitants of the intestinal floras of humans and warm blooded animals, and as such are released into the environment by animal waste (and fertilizers of animal origin). In contrast to coliforms and other intestinal indicator bacteria, the enterococci are rather tough and can survive for long periods of time in soil and water, and thus reenter the food chain. The fact that enterococci that are resistant to all presently available antibiotics have started to appear, possibly due to the use of drugs such as avoparcine in agriculture, is regarded as very alarming. Due to the high risk that resistant enterococci or resistance genes will spread via the food chain to humans from animal waste and natural fertilizers, we need to know more about the epidemiology and ecology of both normal and resistant enterococci.  Objectives: The overall objectives of the present proposal are to generate knowledge of the ecological and epidemiological role of enterococci in the food chain, and of their possible threats to human health due to resistance development and transfer of resistance. The project will involve studies on: 1, the population structure of enterococci from farm land, animal feed, animals, animal carcasses, vegetables, humans, and sewage in different areas within the EC; 2, the antibiotic resistance patterns of enterococci from the above sources; 3, the population structure of antibiotic resistant enterococci versus non resistant strains; and 4, the diversity and the epidemiology of resistance genes and the resistance mechanisms among enterococci.  Working plan: Samples from different reservoirs in the food chain (natural and artificial fertilised soil, sewage, water), animal fodder, animal faecal material, food (meat and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Mesoscale Ocean Remote Sensing Experiments for imaging and modelling of internal wave fields by radar sensing'.

assistant: **Objectives**

Radar systems (spaceborne or airborne) are active non-disturbing sensors for ocean surface watch. Since the US SEASAT (1978) satellite much understanding has been gained on the possibilities of SAR (Synthetic Aperture Radar) technology. It is established that ocean surface phenomena such as swells, surface slicks, island shadowing etc. are visible on Radar images as well as subsurface hydrodynamic phenomena such as internal waves, internal tides, tidal currents, meddies etc. In addition to physical oceanographers many different potential users covering a wide variety of marine activities, have expressed a need for local and/or global wave information. Knowledge of wave conditions will assist such fields by increasing the information relevant to their area of interest but also by reducing the costs and improving safety of many operations. Obviously in serving all these needs, softwares to extract information from Radar images are required. To provide real management tools, human intervention in their use has to be reduced as much as possible. The purpose of this proposal is to contribute to the -development of such precompetitive global tools. To achieve this goal we nedd independent numerical models which are capable of predicting Radar backscattering for all Radar bands, of extracting ocean surface characteristics at high spatial resolution, of predicting internal wave fields in time and space and of inverting Radar signatures into geophysical parameters. Present used models are not totally reliable to produce quantative results in order to retrieve the 3D structure of the ocean's hydrodynamic. Progress in the understanding and mathematical description of different processes and increasing capacity of modern computers opens the door towards much more detailed, comprehe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Recuring breast cancer early genetic diagnostic on a chip' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall objective of RBCE-GenoDiagnoSens is to exploit breakthroughs at the confluences of micro-, nano- and bio-technologies to initiate the creation of a low-cost minimally-invasive intelligent diagnosis system using a nanotechnology-based device for the early detection of DNA biomarkers involved in breast cancer, especially found in circulating tumour cells (CTCs). The device will consist of an array of nano-biosensors for the consecutive RNA/DNA analysis of cancer cells. The advantages of the exploited biosensors for RNA/DNA analysis are their sensitivity, their inherent selectivity, their versatility and their cost effectiveness.  Death from cancer is usually due to metastases that are formed by hematogenic or lymphatogenic spread of cancer cells from the primary disease site. Fortunately, only a subset of these persist and have the ability to form vascularised macro metastases. Therefore, the quantification and characterisation of circulating tumour cell mRNAs in order to define the metastatic potential is of clinical relevance and may prove valuable for monitoring disease progression and patients response to treatment, and assessing the risk for metastasis or recurrence. With prognostic implications, the quantities of mRNA markers in blood could indicate the stage of cancer progression and the need for more intensive therapeutic intervention to better the outcome of cancer patients. In the frame of the RBCE-GenoDiagnoSens, the leading research scientist will design, taylor and test the optimum surface chemistry for the functionalisation and operation of the nano-biosensors, following his established expertise in the field, while the host institution will provide the complementary knowledge and training in microfabrication, DNA expertise, mass-manufacturing, r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Low cost, specialised fibres for crack retardation in cast ceramics'.

assistant: **Concept**

Cast ceramic items are particularly fragile before they have been ftred and are notoriously brittle when they have been fired. These factors lead to very high (up to 15%) losses during production and to a rather heavy finished product with many restrictions on design. The objective of this project will be to develop a fibre that when added to ceramic bodies in small quantities will inhibit the growth of cracks in both the unfired and fired conditions. This will help to reduce production losses, reduce the consumption of energy and materials and allow greater freedom of design. Each of these factors will assist the European ceramics industry in meeting competition from other parts of the world. A consortium of seven companies, and two subcontractors, from six European countries has been assembled, including a major industrial supplier of fibres, some ceramics manufacturers and a University Department specialising in advanced fibre technology. The first half of this four year project will be devoted mainly to the development and evaluation of fibre materials and production processes. Earlier study of the mechanisms for fracture in ceramic materials has provided a definition of the properties required for these fibres and has identified an extensive range of characterisation techniques both for the fibres and for ceramic bodies stengthened by the fibres. Major challenges will be to produce fibres of rather small diameter from materials compatible with both the ceramic matrix and the manufacturing processes casting, drying and firing). Potential fibre technologies developed in the laboratory will then be evaluated by the industrial partners through pilot and demonstration trials. Care will be taken, in light of recent concern over health and safety matters realating to fibr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stochastic Quantisation of Quantum Field Theories with Bosons and Fermions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The mathematical foundation of Euclidean quantum field theory is a very active research area which has long been a central topic at the intersection of mathematical physics and probability theory. A general probabilistic framework to describe quantum fields called stochastic quantisation was proposed in the early 80's by the Nobel prize Giorgio Parisi, in collaboration with Yongshi Wu, and consists in the description of interacting quantum fields via the solution to some stochastic differential equation. The proposal aims at exploring novel directions in stochastic analysis that would allow for a fruitful continuation of the stochastic quantisation programme. Namely, the goal of the proposal is the extension of the known stochastic analytical methods in order to be able to construct quantum field theories for Fermi fields with large-scale singularities and quantum field theories for Fermi and scalar or gauge fields with small-scale singularities.


**Keywords:** Stochastic Analysis, Stochastic Quantisation, Quantum Field Theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Improving the Treatment of Head and Neck Cancer without Additional Side Effects'.

assistant: **Innovation**

Head and Neck (H&N) cancer is the 6th most frequent cancer and the average 5-year survival following the diagnosis is below 50%. Radiation therapy (at times combined with chemotherapy) is currently the most common method to tackle H&N cancer. Yet, its effectiveness goes hand in hand with its toxicity levels, and hence its side effects. Our mission at Sensius is making the treatment of H&N cancer more effective without undesirable additional side effects. And the key innovation to achieve this mission is hyperthermia. There are numerous scientific evidences that warming up the tumor to about 42 °C improves its sensitivity to the radiotherapy treatment. In fact, there are already multiple solutions of the market offering devices for hyperthermia working on several types of cancer, but not for H&N cancer. Our HyperCollar3D is the first device based on hyperthermia for H&N cancer. The HyperCollar3D has been tested by over 70 patients at the Erasmus Medical Center in Rotterdam with excellent results: patients have a 50% higher chance to be cured when hyperthermia is used as a complement of radiotherapy. These results have been validated by the scientific community, published on peer- reviewed medical journals and presented at scientific conferences.This innovation has a huge business potential: only in EU & USA markets we could have about 50,000 new users every year. Other manufacturers already commercialize hyperthermia solutions for cancer treatment, but none of them focuses on H&N cancer because this area is complicated to treat. The IP of the HyperCollar3D has been protected with a European patent. The team behind the HyperCollar3d is top notch: the five founders of Sensius are a mix of medical, technical, and business expertise and they together wield decades of experie