RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microbial extracellular polymeric substances based-technology for selenium removal from drinking and wastewater using CSTR and UASB reactors' (BIOTAC).

assistant: **Innovation**

Selenium (Se) is a naturally occurring trace element in the earth's crust. Microorganisms and their metabolites, such as extracellular polymeric substances (EPS) play a major role in the redox transformation of metalloids in the environment. However, how EPS affects Se oxyanions redox cycling in drinking water and wastewater, what the underlying mechanisms, especially electron transfer mechanisms between EPS and Se, and which components of EPS are involved in Se redox transformation are unclear. Especially concerning electron transfer mechanisms between EPS-Se oxyanions to form BioSeNPs and which redox-active components of EPS are involved in the redox cycling of Se oxyanions. How EPS-mediated reduction of Se affects the isotopic fractions of Se during the reduction process. To what extent do these pure cultures strain-derived EPS-Se oxyanions reduction mechanisms apply to the Continuous Stirred Tank Reactor (CSTR) and an Up-flow anaerobic sludge blanket (UASB) reactor system for water and wastewater treatment, respectively. In this research, we plan to set up in situ and in vitro microcosms combined with electrochemical and spectroscopic techniques to examine 1) the key agents and structural components of EPS involved in the reduction of Se(IV/VI), 2) the electron transfer mechanisms between EPS and Se oxyanions for the reduction of Se(IV/VI); 3) the significance of the Se reduction to the environmental fate and recovery of BioSeNPs in CSTR and UASB reactor. The roles of EPS-mediated reduction processes on the isotopic fractions of Se. The results from this project will be vital to clarifying the role of microbial EPS and their components in the BioSeNPs cycle and developing biotechnologies to remediate and recover environmental Se.


**Keywords:** Microbial Biotechnol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GENE REGULATORY NETWORK CONTROLLING THE ROOT STEM CELL NICHE IN ARABIDOPSIS THALIANA' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Plant stem cells are located in apical meristems at the growing tips of the shoot and the root. Signals from the neighboring organizing center within the shoot or quiescent center (QC) within the root maintain the stem cells in an undifferentiated state. The homeobox gene WUSCHEL-RELATED HOMEOBOX 5 (WOX5) is QC-specifically expressed and plays a central role in the control of the distal stem cells. However, the downstream factors of WOX5 and the molecular events triggered by WOX5 activity are not understood.Therefore, this project is intended to identify WOX5 primary target genes and to elucidate the roles of factors acting downstream of WOX5 in stem cell regulation. From pilot experiments, the first candidates for WOX5 target genes have been identified.  I will perform a thorough transcriptome profiling of the QC, verify candidates by WOX5 protein -DNA binding studies in vivo, and by functional characterization. Furthermore, systems biology approach of the WOX5 downstream factors will be used for the construction of a regulatory network involved in stem cell niche signaling. Taken together, the proposed project will deepen the knowledge of how cell-cell communication in the stem cell niche functions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering context-dependent roles of oncogenic gene fusions in vivo' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Sarcomas are an extremely heterogeneous group of mesenchymal cancers, many of which remain lethal despite decades of clinical trials. A unifying characteristic in pediatric sarcomas is their low mutational burden. Instead, they frequently harbor an entity-specific chromosomal rearrangement giving rise to an oncofusion protein that acts as the disease driver. This genetic simplicity underlying a complex group of tumors implies a synergy between oncofusions and the cellular context in which they occur. However, the cell-of-origin for the vast majority of sarcomas is unknown. We have developed a flexible method for somatic engineering of the mouse muscle to model more than 10 genetically distinct pediatric sarcoma subtypes. Here we will take advantage of this unique tool to understand key questions so far unanswered due to the lack of suitable sarcoma models and flexible genetic approaches:1.What is the identity of the cell(s) of origin and why are they permissive to transformation? 2.Are gene fusions required for tumor maintenance? And if they are, to what extent is transformation reversible? Do tumor cells retain memory of their previous normal states? Or there is a point of no return when they forget what they used to be? By combining our models with transgenic mouse lines that allow in vivo cell barcoding, we will trace, isolate and characterize different population of cells in normal muscle and in primary tumors to identify and study sarcoma cells-of-origin. To understand the role of gene fusions in tumor maintenance we will apply the degradation system (dTAG) for in vivo acute degradation of oncofusion proteins. Temporal and spatial analysis will allow to dissect complex biological responses to oncogene withdrawal. These approaches will combine cutting-edge technolog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Social Transformation for Water Stewardship through Scaling Up Citizen Science' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

OTTERS will aim at promoting and scaling up successful citizen science (CS) initiatives in the marine and freshwater domains via 1) accelerating the co-creation of standards in data collection, semantics, data quality, and data management making sure to abide by all ethical and legal standards; 2) promoting and scaling up successful water-related CS initiatives by clustering them under co-designed Spring-to-Sea campaigns to foster agency and increase ocean literacy; 3) connecting the citizen-generated data to other EU-funded projects and portals, including the European Marine Observation and Data Network (EMODnet) and Digital Twins of the Ocean (ILIAD) to ensure the accessibility and reuse of the data and abide by all FAIR principles; 4) demonstrating the effectiveness of citizen science in participatory research, environmental monitoring and changing people’s behaviors to ensure the sustainability of water ecosystems and reach the goals of the EU Water Framework Directive and UN Decade of the Ocean.


**Keywords:** Citizen science, water, ocean, open data, pollution, stewardship, participatory design and governance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SAIL&CLEAN – A complete solution for sea cleaning: marine litter removal and optimal algal bloom harvesting' (SAILCLEAN), addressing dissemination and exploitation.

assistant: **Impact**

Europe is currently facing a huge and complex challenge when it comes to cleaning its oceans. On one hand, marine litter represents a tremendous environmental problem. Plastics pose a serious threat to all marine animals, as well as to boats and coasts. There are more than 150 million tonnes of plastics accumulated in the world's oceans while up to 8 million tons are added every year. On the other, eutrophication is causing an intensification of harmful algal bloom episodes, which lead to fish die-offs, cities cutting off water to residents, or states having to close fisheries. In the EU the annual cost of those blooms surpasses the €900 million. Municipalities and public authorities in charge of the preservation of the coasts still fail at targeting these issues at the same time because current solutions consist of either simple barges that collect debris in shallow waters or boats that can harvest the undesirable algae but unable to remove litter. Asco Harvester is an Icelandic SME committed to the development of a new family of efficient and sustainable boats that can tackle these two problems thanks to their dual functionality. Our boats can mow toxic algae and clean garbage and other waste from seas and ocean waters simultaneously. ASCO boats exhibit a very high harvesting productivity (40% higher than current harvesters) and are capable of working in difficult areas, such as fjords, open oceans or river canal. In addition, they incorporate a very efficient module able to capture up to 15 tons/day of plastic and other marine litter. We have implemented a business model based in selling and renting our boats to respond to seasonal demands thus maximising our business opportunity. By the end of 2024 (five years after market launch), we expect to have 70 units in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Variational approach to the regularity of the free boundaries' in the context of a Horizon 2020 call.

assistant: **Objectives**

The focus of this project is the regularity theory of free boundary problems. This is a fascinating topic, which combines methods from Analysis and Geometry, and has numerous applications to a large variety of problems in Physics, Engineering and Economy, which involve partial differential equations on domains whose boundary is free, that is, it is not a priori known. Typical examples are the Stefan problem, describing the evolution of a block of melting ice, and the American stock options. Since the shape of the boundary is free, it is a deep and usually extremely difficult question to study its fine structure. The regularity theory is precisely the art of deducing the local structure of the free boundary just by looking at a global energy-minimization property of the state function. In this project I aim to develop new techniques to study the regularity of the free boundaries and to give a precise description of the structure of the free boundaries around singular points. I will introduce a new variational method for the analysis of the free boundaries, aiming to solve several major open questions related to the classical one-phase, two-phase and the vectorial Bernoulli problems, the obstacle and thin-obstacle problems, which are the most important models both from a theoretical and applicative point of view. The techniques that I will develop in this project will have an impact on several domains, including the minimal surfaces, harmonic maps, free discontinuity problems, parabolic and non-local free boundary problems.


**Keywords:** free boundary, regularity, singularities, one-phase, Alt-Caffarelli, two-phase, Alt-Caffarelli-Friedman, obstacle problem, thin-obstacle problem, epiperimetric inequality, monotonicity formulas, shape optimization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European Newspace Vertical Orbital Launcher' in the context of a Horizon 2020 call.

assistant: **Objectives**

ENVOL main objective is to provide Europe its prime commercial, competitive and green launch service, utilizing a true New Space approach to offer low-cost, frequent and flexible access to space to small satellites in the range of 100 to 200 kg by 2024. To achieve this goal, the tip of the spear of European innovative space launch companies has joined forces to develop a vertical orbital launch system that will:•Act as an accelerator for the growth of the European New Space economy; •Be competitive and prevail in a contested and global market;•Attract enough investment to reach the tipping point of commercialization;•Target achieving the first European orbital launch from Continental Europe;•Compete for the EC Horizon Prize on European Low-Cost Space Launch;•Be the first orbital launcher worldwide to use green hybrid rocket propulsion.The project will run for 36 months, with 9 industrial companies from 7 European countries. The total EC contribution is 3 987 416 Euro, and the main outputs of ENVOL are:•A detailed definition of an innovative and industrial low-cost European launch system •A total of four ambitious launch vehicle demonstrators on the turbopump, tank and structures, launcher avionics and payload avionics, advancing the maturity of critical launcher technologies to ensure market readiness and competitiveness.•A business plan grounded by industrial expertise, along with a development plan and the identification of the organization capable to attract investments and to ensure that the work performed in this project transforms into a commercial activity servicing the small satellite launch market in Europe and beyond.


**Keywords:** launch system, hybrid propulsion, composite tank
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An integrated pilot line for micro-fabricated medical devices'.

assistant: **Objectives**

The goal of the InForMed project is to establish an integrated pilot line for medical devices. The pilot line includes micro-fabrication, assembly and even the fabrication of smart catheters. The heart of this chain is the micro-fabrication and assembly facility of Philips Innovation Services, which will be qualified for small/medium-scale production of medical devices. The pilot facility will be open to other users for pilot production and product validation. It is the aim of the pilot line: to safeguard and consolidate Europe’s strong position in “traditional” medical diagnostic equipment, to enable emerging markets - especially in smart minimally invasive instruments and point-of-care diagnostic equipment - and to stimulate the development of entirely new markets, by providing an industrial micro-fabrication and assembly facility where new materials can be processed and assembled. The pilot line will be integrated in a complete innovation value chain from technology concept to high-volume production and system qualification. Protocols will be developed to ensure an efficient technology transfer between the different links in the value chain. Six challenging demonstrators products will be realized that address societal challenges in: “Hospital and Heuristic Care” and “Home care and well-being,” and demonstrate the trend towards “Smart Health” solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International PhD Programme for Medical Doctors' (EMERALD).

assistant: **Concept**

Addressing the increased need for innovative solutions in medicine and healthcare, as we are witnessing during the current worldwide pandemic, requires more than ever the rise of the unique professional profile of physician-scientists, combining cutting-edge research and technology with medicine. There are several MDPhD programmes in European countries and institutions, but there is none Europe-wide. The EMERALD International Doctoral Programme aims to nurture excellent physician-scientists to advance research, personalised medicine and health care in Europe. Following fair, merit-based, and inclusive recruitment, the programme will hire 24 medical doctors to carry out a PhD in cutting-edge research in seven European centres of excellence in life sciences and biomedicine. The EMERALD fellows will experience mobility across laboratories, sectors and countries, and they will benefit from international, stimulating and creative environments, advanced training, career development and mentoring programmes, and access to high-end technologies and facilities. Importantly, they will benefit from the advanced training on the latest technologies, digital skills, open science and innovation, and from the mentoring provided by the EMERALD programme, with the opportunity to build valuable international networks with different actors in academia, hospitals, industry, patients´ organisations and NGOs. EMERALD counts on the impressive support and collaboration of 37 partner organisations from 10 European countries. The trained physician-scientists will be equipped with skills and knowledge to tackle relevant clinical and research questions, bridging the gap between laboratory research and caring of patients, and ultimately pursuing new approaches to diagnose and treat human diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cross Border SESAR Trials for Enhanced Arrival Management' to be submitted under Horizon 2020.

assistant: **Abstract**

There are periods during the day when variation in aircraft arrival times combine to exceed the capacity of the destination airport to handle them without incurring airborne delay. Such delay causes increased emissions and noise in the vicinity of the airport, as well as increasing the aircraft operator’s fuel costs. Greater congestion increases the air traffic control workload and can result in less efficient aircraft profiles.To reduce airborne delays near the destination airport and the associated negative effects, two concepts can be used. One is to adjust an aircraft’s departure time by holding it on the ground so that its arrival time avoids the predicted peak in arriving traffic. Other methods involve trajectory extension or slowing down an aircraft in flight. This requires the arrival sequence to be calculated earlier than in current operations so that action can be taken early enough to have a meaningful effect.The XSTREAM project will demonstrate the benefits gained through this latter concept. These methods can be used in combination with the former concept, traditionally regarded as a network management action, but refined through the use of arrival management tools. The project will demonstrate the use of arrival management techniques for pre-departure aircraft, the calculation, updating and passing of arrival management actions for airborne aircraft such as target time, time-to-lose/gain, or speed advisory from the destination arrival management system to upstream control units, and the impact of multiple arrival constraints within an Upper Airspace Control unit.The operational demonstrations will be performed upon aircraft arriving at Paris CDG and Orly, London Heathrow and Gatwick, and Zurich. These optimized arrivals will be supported by several en-rout
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Poison-resistent catalysts for clean diesel production from lco' (RESCATS), addressing dissemination and exploitation.

assistant: **Impact**

Realisation of environmental compatible processes is strictly related to the development of heterogeneous catalysts and to the waste recycling. In particular future standards for diesel fuels will require lowering of aromatic and sulphur content. Therefore, oil refining must make use of new catalytic systems. The proposal is addressed to synthesis, characterisation & testing of new catalyst to recycle light cycle oil, to clean diesel fuel by mild hydro treating. The catalysts used for hydro treating are based on us and Japanese patents. The development of novel EU catalysts is the main objective of this proposal. The work is mainly devoted to the syntheses of bimetallic catalyst using precious and non-precious metal alloys on different supports, which will be tested at lab-scale, before formulation and scale-up for pilot plant. Low cracking, resistance and hydrogenation yields will be the criteria to select supports and catalysts.