RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ultra-compact, low-cost plasmo-photonic bimodal multiplexing sensor platforms as part of a holistic solution for food quality monitoring' under Horizon 2020.

assistant: **Concept**

As consumer demand for fresh fruits and vegetables (F&V) continues to increase, so does the risk of microbiological and chemical contamination. Currently, inspections for F&V are carried out at the production site or the food processing facility, based also on regulatory requirements. In most cases these are inspections of random batches using laboratory techniques, which may require up to two or more days before getting results. The time and cost per analysis leads to reduced checks and thus, elevated risks, even in countries with very efficient control mechanisms. Furthermore, such analysis cannot take place in all parts of the value chain (due to time requirements, but also due to associated cost), including supermarkets or restaurants, which are critical points since this is where the consumer will get the products from. GRACED considers the aforementioned need and the limitations of current techniques and proposes a novel solution for contaminants detection in all stages of the F&V industry value chains. The heart of the proposed solution is a novel plasmo-photonic bimodal interferometric sensor, combined with low cost on-chip light generation, capable of simultaneously and quickly detecting different analytes of interest. The sensor will be part of holistic, modular solution that exploits unique engineering designs, IoT concepts and advanced data analytics, for the early detection of contaminations in the F&V value chains. The approach will be validated in different production & distribution systems: a) a conventional farming system in open-air farms and the follow-up steps of food processing for preparing cooked meals and frozen vegetable packages, b) a novel, urban farming ecosystem, producing F&V locally and using them in in-situ restaurants, c) a short value c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A quorum sensing mechanism regulating CD4 T cell proliferation'.

assistant: **Concept**

The fine and complex regulation of CD4 immune response is important in cancer, autoimmune diseases, inflammatory disorders and viral infection. If signals orchestrating productive CD4 T-cell responses are well documented, the contraction of antigen (Ag)-specific CD4 T-cell populations following the resolution of primary immune response is however not molecularly understood. It has been demonstrated that a negative feedback loop can regulate CD4 T cell proliferation through direct T-T interactions, leading to the preferential exclusion of Ag-experienced T cells. This T cell intrinsic mechanism limits the expansion of effector CD4 T cells and may then interfere with therapeutic vaccine efficacy. Using Cas9-(constitutive/inducible)-expressing Dby-reactive T cells (from a TCR Transgenic RAG-/- mouse strain named Marilyn) coupled to a sgRNA library and an in vivo selection strategy, we will extensively identify the negative regulators of CD4 T cells migration and priming in an ongoing primary immune response. As a proof of concept, we will first inactivate candidate genes (already known to be involved in CD4 T cells negative regulation: TGF-b receptor,IFN-γ receptor, PD-1 and PD-L1) in Ag-experienced memory CD4 T cells, which will be enriched for their proliferative capacity in vivo and used as a second cohort in immunized mice. Then, we will develop a genome-wide screen approach to generate a library of knockout Ag-experienced T cells as a second cohort. We expect that further insight into CD4 suppressive mechanisms, which dampen efficient antitumor immune responses, will allow optimization of cancer immunotherapy.


**Keywords:** CD4 T cells proliferation,  inhibition,  CRISPR, genome wide screen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MOLECULAR MECHANISMS OF COLONIZATION RESISTANCE AGAINST C. DIFFICILE AND C. PERFRINGENS' in the context of a Fourth Framework call.

assistant: **Objectives**

Gut microbial microflora is composed of more than 1014 bacteria representing more than 200 species. It comprises both endogenous (resident) and exogenous (transiting) bacteria, which in healthy humans are kept under tight equilibrium. The participants 1 and 5 have developed simplified models in mice that represent a minimal resident flora capable of inhibiting implantation of C. difficile (Model 1) and C. perfringens (Model 2). In the latter model, preliminary data explaining the mechanism of inhibition have been obtained, whereas in the former model the mechanism remains to be explained.The objectives concerning the Model 1 are twofold :First, we shall attempt to elucidate how the barrier microbiota exert their inhibition towards C. difficile. Since no antibiotic substance has been identified that would explain this effect, we shall focus on the interactions between the three partners that are involved : the host, the barrier flora and C. difficile. We shall in particular investigate the adhesion to and degradation of mucus by mucinolytic enzymes by the barrier flora and C. difficile, and the composition of mucus at each step of implantation. This will give information concerning possible receptor structures for the barrier microbiota and may elucidate the potential role of these substances as nutrients, antimicrobial substances of chemoattractants. In addition, some of the genes coding for mucinolytic enzymes will be isolated in order to construct mutagenised barrier strains, which will shed further light on the nature of interactions between the barrier microbiota and the mucus layer that normally covers the intestine. Finally, further biochemical characterisation of the barrier strains will be attempted. Second, more information has to be gained about the target of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Ecological correlates of storage and migration strategies in a capital-breeding oceanic ‘jellyvore’ multiyear migrant turtle'.

assistant: **Concept**

There is currently a growing concern about the impacts of climate change, over-fishing and fisheries bycatch on marine environments and natural resources worldwide. A worrying example is notably the jellyfish proliferation to the detriment of other marine organisms in overexploited marine ecosystems. This shift may have high ecological and economical consequences. High trophic level predators integrate and amplify the effects of environmental forcing on lower levels throughout food chains while migrants are integrators of global processes as they may feed in some parts of the world and reproduce in others. The oceanic “jellyvore” multi-year migrant leatherback turtle may thus constitute a key bio-indicator of short- and long-term changes in food-webs and resource availability in marine ecosystems. This project will thus focus on the adaptive strategies of this critically-endangered species facing environmental constraints and will tackle one of the most important questions relating to the global change impacts on marine biodiversity. We will assess for the first time in marine turtles the links between the environmental conditions and the individual life history strategies, i.e. the individual migration, storage and reproductive strategies. Through a European collaboration between the Royal Netherlands Institute for Sea Research (NIOZ, the Netherlands) and IPHC (CNRS, France), I will be able to use stable isotope and original tracking techniques to investigate the migration and storage strategies of female leatherbacks of known-identity and known-reproductive history. Such a unique long-term database is available in French Guiana, one of the main leatherback’s nesting sites in the world. This project will help better understanding the underlying factors of leatherback p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New-generation database capacity planning optimization', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Megatrends of outsourcing, virtualization and migration of data to the cloud lead companies to invest massively in IT infrastructure. This is due to current capacity planning techniques being based on manual estimations with very limited automatization to anticipate necessary growth. Based on their estimates, they invest in excess resources, leading to an over dimensioned infrastructure in which 30 to 50% of capacity is not used. DB PRO have developed a unique and patented new-generation solution that allows capacity optimisation of large scale data platforms achieving savings above 50% from traditional approaches: Governor. Our tool is based on server consolidation, an approach to the efficient use of computer server resources to reduce the total number of servers than an organisation requires. Governor® software enables companies to save in licensing and services fees by giving an accurate system’s capacity optimization without compromising databases’ performance. Since 2015, we have been able to test a Beta version of our technology at a real company client. In 2016 we developed Governor®5.0, a version with new features applicable to physical environments, which has also been tested at another company. In both cases the companies achieved savings of 50%. We have since also signed a partnership with Crayon, one of the largest Software Asset Management (SAM) and licence reseller of Microsoft licenses companies in Norther Europe. With our next GOVERNOR generation, we will adapt our technology to target virtual environments (75% of current servers) and expand toward other database platforms. We will also further develop our successfully proven business model, based on establishing distribution agreements with SAM and licence reseller companies, aiming to eventually reach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'OPen WIreless OzoNe SEnsor NEtwoRk for smart environmental monitoring of remote areas: crossing the Alps along the 12th east meridian on the trail Munich Venice'.

assistant: **Objectives**

Atmospheric observatories are currently the primary infrastructure for the state-of-the-art meteorological and climate research. However, the World Meteorological Organization Global Atmosphere Watch (WMO-GAW) states in their 2018 final report that the fate of the next generation of monitoring stations will be dramatically modified by the breakthroughs of new low-cost sensors (LCSs) technologies. The rapid development and continuous improvement of low-cost technology are demonstrating notable applications and today “LCSs are beginning to play a role in areas such as model or emissions validation and spatial variability in pollution” in support the state-of-the-art instrumentations and established networks. New upcoming atmospheric applications, services and support in citizen inclusion in earth monitoring are pushing European Union (EU) in funding scientific communities, companies, governments and international bodies such as the Joint Commercial Advisory Group (JCAG) in developing and assessing low-cost technology, thus making the introduction of basic and applied research addressing quantitative, reproducible measurements, guidelines for best practice, high data quality and accuracy, compatibility of data imperative. Considering these crucial challenges, aim of the project is to establish a low-cost sensors wireless sensor network (LCS-WSN) to assess the effectiveness of low-cost technologies in the study of transboundary transport phenomena. Given its highly relevance for the Earth’s climate, ecosystems, and human health as stated by the International Global Atmospheric Chemistry Project, primary endeavor will be directed towards the study of Ozone. Main target is to develop a highly reliable LCS-WSN to be used by scientists as well as citizen engineers in remote are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'familiados.com - a marketplace for professional caregiving' (FAMILIADOS).

assistant: **Concept**

familiados.com is a marketplace on line where families can find, select and hire caregivers. Caregivers can create profiles,showing education, specialization, experience and availability; they also choose their hourly rate and the area where theywant to work. Families, on their side, can search, find profiles with the specific skills for their need, request availability, closethe deal directly with the caregiver and rate the service.All of it in an open platform, where familiados role is to facilitate the interaction, making sure that the profiles include trueinformation, that families can evaluate their experience and that the transactions take place in a seamless and fluid way,from the beginning to the end, from selection to payment and evaluation.The two main differential features of familiados are: (1) it specializes in care services for seniors, disabled people andhospital companionship; and (2) it is focused in temporary needs, short term assignments.And the way we will fundamentally change the way this market works now is: (i) by offering caregivers a tool toprofessionalize their offer, allowing them to reach the market in a differentiated way and be seen as valuable professionals;and (ii) by offering families the tool to select and choose a group of favourite caregivers to take care of their needs, ensuringavailability and the right professional for the right need.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Antecedents and outcomes of followers' perceived satisfaction with their role' under Seventh Framework.

assistant: **Concept**

The world is not made up simply of leaders and followers. The roles have always shifted (Baker et al., 2011), and overlapped (Kellerman, 2008), in one’s working life. This has not changed, but jobs have. Boundaryless careers, job insecurity and slack labor markets erode old certainties, and workers’ chances for advancement have been stymied or delayed. The question is no longer only what makes leaders and followers different, but what we can do to make followers more satisfied with their role. If we think of the impact that leadership and leader-member exchange have on motivation, performance and wellbeing (e.g. Nielsen et al., 2008 - for transformational leadership; Harris et al., 2011 - for LMX), it can readily be imagined that the extent to which followers are satisfied with their role can also impact these dimensions.The project’s ultimate goal is to gain a better understanding of followership by focusing on followers’ perceived satisfaction with their role in the relationship with the leader. This dimension, called SF, is not just the satisfaction of being a follower.Two specific goals will be pursued:1) Investigating SF antecedents: Control variables linked to the relationship (e.g. duration of relationship, etc.); implicit theories of followership and leadership; personal variables.2) Investigating SF outcomes: Motivation-related dimensions (work engagement, motivation to lead and to follow), as well as variables concerning health impairment (e.g. emotional exhaustion).To achieve these goals, we will carry out a longitudinal study with three surveys (T1-antecedents; T2-SF; T3-outcomes). The study will use dyads of followers and leaders.Small and medium enterprises (SMEs) were chosen for the study, as the success of such organizations may hinge on followership tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Aquired Environmental Epigenetics Advances: from Arabidopsis to maize', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal, entitled “Acquired Environmental Epigenetics Advances: from Arabidopsis to maize” (acronym: AENEAS), aims to assess the impact of environmental conditions on epigenetic states in the model plant Arabidopsis thaliana and then transfer knowledge to maize (Zea mays): an important European crop. Advances in understanding the detailed mechanisms of epialleles formation in response to environmental cues and their heritable maintenance in a model plant such as Arabidopsis will be the starting objective of the AENEAS proposal. To this end, we will focus on three epigenetic regulatory pathways, which have been well characterized for their interaction with environmental signals in mediating changes into the epigenome. They are: the autonomous, the small RNA and the CpG methylation pathways. The outcome of this research activity will be a road map for plant environmental epigenetics, necessary for further progress of the basic research in this area and for the transfer of the knowledge to crop plants. Concomitantly, the constitution of an “Environmental Epigenetics platform” for maize, will start with the development of tools indispensable for the shift of epigenetic research from Arabidopsis to maize. This will be achieved by the functional characterization of maize mutants for epi-regulators belonging to the three pathways studied in Arabidopsis. The tools will comprise: maize epi-regulator mutants, their targets, and information about their interaction with environmental cues for epialleles formation and inheritance throughout generations. It is our opinion that the deliverables from AENEAS will be the “progenitors” for the next-generation of breeding programs, based on the exploitation of the environmental-induced epigenetics variability. In addition, we will co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Democratizing quantum computing with 3D scalable and customizable quantum processors:' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Quantum computing is moving from a research field to an emerging industry. But quantum computer integrators face a critical bottleneck: quantum processing units (QPUs) are exceedingly scarce. If a team of innovators envisions a new type of quantum computer, they have two main options. They can either raise enormous capital and build their own QPUs or rely on a university lab for support. This situation reinforces the dominance of incumbent tech giants and stifles innovation when the field needs it the most.  We reduce the capital intensity of the field by bringing customizable, scalable, and affordable QPUs to the market. We achieve this by combining three proprietary technologies: parameterized designs, high-yield fabrication, and scalable 3D architecture. We have demonstrated our ability to deliver fully packaged QPUs in less than 30 days to our customers. This project will advance our 3D architecture from prototype to product and offer our customers modular 1000+ qubit QPUs.


**Keywords:** quantum computing,quantum hardware,superconducting qubits