RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Stimulation of fish larval defence mechanisms against infectious diseases' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Infectious diseases are major obstacles within European hatcheries . To cope with this, examinations of the ontogeny appearance of cells fighting pathogens and of the humeral and cellular ant microbial defence mechanisms must be performed. Once our understanding of these defence mechanisms such as the complement system, antibodies, proteases/ant proteases and leukocyte appearance and function is improved, strategies to prevent infectious diseases must be developed. These strategies include the use of immunostimulants and vaccines to increase the disease resistance against abundant pathogens such as atypical Aeromonassalmonicida, vibrato angular, SVCV, IPNV and VNN virus which are reported to cause mass mortality within European hatcheries. The commercially emerging and developed fish species that will be examined are: Sea bass, Atlantic halibut and cod, spotted wolfish and carp. The project does not involve Use of Gomes .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reconstituting citizens: Public involvement as enactment of issue entanglement' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

This research project addresses challenges to dialogic, procedural understandings of citizen involvement in the politics of science and technology, by elaborating a pragmatic conception of such involvement. Focusing on citizen involvement in climate change, its main objective is to develop an advanced understanding of such projects as enactments of actors' entanglement in issues.A second aim of the project is the analysis of the formative role played by information technologies in enabling the performance o f citizenship (as pragmatically reconceptualised). Finally, the citizen involvement projects that are studied, along with the role of IT therein, will be subjected to realistic evaluation, focusing on the facilitation of relevant civic engagement.To achieve these goals, the project begins by evaluating criticisms of dialogic, procedural approaches to public participation in political theory, and by exploring how constructivist studies of science, society and democracy help to address these. On this basis, the project develops the issue-oriented conception of citizen involvement, underpinning this elaboration by detailed empirical research. With the aid of Web analysis and fieldwork, studies will be conducted of specific citizen involvement projects concerned with climate change. The analysis will pay particular attention to the function of socio-technological formats (e.g. blogs, communications initiatives) in facilitating the performance of citizenship in this respect.The project will allow the applicant to complete her expertise by enhancing her skills in conducting empirical research on citizen involvement. As a researcher with extensive experience in social and political theory and Web analysis, the addition of these skills constitutes an important contribution t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Women's journey through entrepreneurship in the tourism industry' in the context of a Horizon 2020 call.

assistant: **Objectives**

As entrepreneurship is fundamental to economic development in the EU, it is essential to maximize the potential pool of successful entrepreneurs by addressing the persistent under-representation of women who constitute only 29% of all entrepreneurs in Europe-37. This is a priority as the proportion of women entrepreneurs has declined since 2008. Tourism is advocated as an accessible entrepreneurship gateway for women because of the predominance of small firms, relatively low entry barriers and the size of the sector (9% of EU GDP). Therefore; tourism provides an important opportunity for women entrepreneurs as individuals, but also for communities and economies at a European level. WomENt aims to understand the different pathways of women’s entrepreneurship journey in a changing tourism industry, and how different environments, agents, policies and actions across different scales (macro, meso and micro) influence their opportunities, motivations and challenges.While the barriers to entrepreneurship faced by women have been studied generically, research on tourism is limited, and the methodologies used have not addressed the complexity of women’s entrepreneurial journeys. Hence WomENt draws on the fresh perspectives provided by a post-structuralist feminist approach, reinforced by mixed methods analyses, to identify key contingent factors that determine effective tourism entrepreneurship practices and performances. The pathways will be analysed in the United Kingdom and Spain, which have contrasting tourism industries and entrepreneurial environments. Research on entrepreneurs’ use of social media, and close collaboration with agents of change (policy-makers, universities etc.), including secondments with key tourism organizations, will ensure the project makes an effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bright nanoparticle probes for amplified fluorescence in situ hybridization in cancer diagnostics' (AmpliFISH).

assistant: **Concept**

Rapidly expanding field of cancer diagnostics generates strong demand for new biosensing tools. In particular, it concerns probes for fluorescence in situ hybridization (FISH), that enables detection of DNA and RNA cancer biomarkers directly in diseased cells. Although FISH technique has already been accepted for cancer diagnostics in clinics, its applications are still limited because the method is slow, expensive and requires complicated amplification protocols to obtain sufficient fluorescence signal. Here, we propose a solution based on ultrabright DNA-functionalized dye-loaded fluorescent polymeric nanoparticles recently developed within the ERC grant BrightSens and protected by two patent applications. We aim to develop ultrabright FISH probes (nanoprobes) for cancer research and clinical diagnostics. These nanoprobes will feature single-molecule DNA/RNA sensitivity, low cost, fast and direct one step cell staining protocol, and compatibility with clinical samples and single-cell assays. The amplification of FISH performance will be ensured by our dye-loaded polymeric nanoparticles of 7-20 nm size that are ~1000 fold brighter than single organic dyes. The project is composed of five tasks: (1) Synthesis and optimization of FISH nanoprobes; (2) validation of FISH nanoprobes in cancer cell lines; (3) development of multiplexing assays for detection at least 9 biomarkers; (4) their validation in clinically relevant samples; and, finally, (5) commercialization of FISH nanoprobes. The developed probes will constitute highly competitive products that can greatly improve performance of FISH assays in clinics and research laboratories and thus impact human health. Therefore, they will be directly proposed for commercialization by licensing to existing companies and/or thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Molecular mechanisms of retinoid receptor function in pluripotent cells'.

assistant: **Objectives**

Research objectives and content Retinoids play a fundamental role in regulation of cell proliferation, differentiation and embryonal morphogenesis. Pluripotent embryonal carcinoma (EC) cells differentiate upon retinoic acid (RA) administration and provide a model system to study the RA-regulation of gene expression during early stages of development. Critical for EC cell differentiation is the transactivation of the RARb2 promotervia retinoid receptors (RAR and RXR) binding to RA-responsive elements (RAREs) in close proximity to the TATA-box. I propose to investigate the role of transcription factor TFIIA in RA-dependent signalling pathway through the RARb2 promoter. In the RARb2 promoter TFIIA overlaps with the 3'-RARE. Since binding of the receptor heterodimer to this element is critical for transcriptional activation, it will be important to assess the requirement for TFIIA in RARb2 promoter transactivation. This study will provide insight not only into the role of TFIIA in retinoid dependent signalling in pluripotent cells but also in transcription initiation, in general. Training content (objective, benefit and expected impact) The molecular biology/biochemical approach proposed will be beneficial to the applicant's training, at both theoretical and technical levels, as an independent researcher. Training of young researchers from less favoured regions of the community is likely to have a major impact on their scientific development. Upon return, the applicant will both introduce the advanced technologies and promote possible collaborations. Links with industry/industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Quantitative Treatment and Testing of Rotational Degrees of Freedom' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Objectives and content The basic research project QUATTRO aims at solving the critical issues which today prohibit the consistent use of rotational degree of freedom (RDOF) information (moments, angular displacements) in test-based and hybrid (test-numerical) structural dynamics modelling. By neglecting them, as it is the current practice, CAE techniques such as substructuring, FEM updating and load analysis, which are in use in many industrial sectors (automotive, components, household, production,...) often fail to yield the expected results, leading to suboptimal designs or even product failures. Therefore, the following activities will be realised:  to systematically analyse and quantify the errors in structural dynamics analysis due to neglecting RDOFS.  to critically assess the accuracy and applicability limits of available RDOF techniques which are inadequate for the targeted applications.  to develop and evaluate novel methods for exciting, measuring and modelling RDOF data with the required accuracy.  to develop and publish guidelines to the use and the measurement of RDOF data in the CAE process.  Furthermore, the realised findings will be evaluated in a number of typical" industrially relevant applications and a round-robin test will be performed. The outcome will hence not only consist of feasible and enhanced techniques and tools, but also a recommended "best practice" for the whole of the European industry will be realised. The partnership to realise these objectives consists of 4 universities, leading the research in this field through complementary technologies, and two industrial companies (one end-user: a manufacturer of a variety of components and products and one IT-SME commercialising advanced CAE tools). Together they combine the required methodolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intramolecular force mapping of enzymes in action: the role of strain in motor mechanisms' (FORCEMAP) under Seventh Framework.

assistant: **Objectives**

A fundamental but unexplored problem in biology is whether and how enzymes use mechanical strain during their functioning. It is now evident that the knowledge of atomic structures and chemical interactions is not sufficient to understand the intricate mechanisms underlying enzyme specificity and efficiency. Several lines of evidence suggest that mechanical effects play crucial roles in enzyme activity. Therefore we aim to create detailed force maps that reveal how the intramolecular distribution of mechanical strains changes during the enzyme cycle and how these rearrangements drive the enzyme processes. The applicability of current nanotechniques for the investigation of this problem is limited because they do not allow simultaneous measurement of mechanical and enzymatic parameters. Thus we seek to open new avenues of research by developing site-specific sensors and passive or photoinducible molecular springs to measure force-dependent chemical/structural changes with high spatiotemporal resolution in myosin. Since force perturbations occur very rapidly, we are able to combine experimental studies with quasi-realistic in silico simulations to describe the physical background of enzyme function. We expect that our research will yield fundamental insights into the role of intramolecular strains in enzymes and thus greatly aid the design and control of enzyme processes (specificity, activity, regulation). Our studies may also lead to new paradigms in the understanding of motor systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Leukemia-Initiating Cell: Genetic Determinants, Escape Mechanisms and Ontogenic Influence' in the context of a Seventh Framework call.

assistant: **Objectives**

Acute myeloid leukemia (AML) is the most common malignant myeloid disorder in adults and strongly associated in incidence to advanced age. AML arises from immature hematopoietic progenitor cells via a sequential multistep process, but the nature of these steps remains to a large extent unknown. Therefore, while significant efforts have previously been invested in characterizing the molecular properties of late-stage AML, as diagnosed in patients, less information is available on the events that underlie leukemia initiation and progression. This includes the identity of potential mechanisms that restrict or eradicate developing leukemic cells; hurdles evaded at some point in time for AML to occur.We have developed an inducible transgenic mouse model of AML that, when combined with high-resolution cell fractionation of primitive hematopoietic progenitor cells, offers a unique opportunity to track development of AML from the very first stages of cancer development. Using this, I propose to: 1) Identify and functionally validate molecular determinants that underlie why only some hematopoietic progenitor cells progress into AML, 2) To explore the extent and identity of immune surveillance/editing that accompany progression into AML, and 3) By building on my previous work on hematopoietic aging, to explore AML progression in the context of aging.I anticipate the LEUKEMIABARRIER project to generate novel basic knowledge, not excluding with clinical relevance, with the potential to open up several new fields for further studies. This includes identification of novel cell-intrinsic regulators and immune responses, their underlying mechanisms, and their relationship to the increased incidence of AML with age.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Galaxy evolution in dense environments' (Fornax).

assistant: **Concept**

The Universe around us is populated with galaxies, each containing from millions to tens of billions of individual stars. Far from being immutable, galaxies undergo profound changes as they age. Their evolution depends on their position in the cosmic web, a network of sheets and filaments of matter that stretches across the entire Universe. The goal of FORNAX is to study the evolution of galaxies in the densest regions of the cosmic web, galaxy clusters. In these regions, a number of physical processes are thought to make galaxies lose their cold gas – the material from which new stars are born – and change their appearance dramatically. I will study these processes in action by observing the flow of cold gas in and out of galaxies living inside an important, nearby cluster of galaxies: Fornax.I will observe Fornax for 2,450 hours with MeerKAT, a new, state-of-the-art radio telescope precursor of the Square Kilometre Array. Thanks to the unprecedented combination of sensitivity, resolution and sky-coverage of my survey, I will reveal the most subtle signs of the removal of gas from galaxies, I will detect the smallest gas-bearing galaxies in the cluster, and I will hunt the elusive cold gas which, according to cosmological theories, floats in the space between galaxies along the filaments of the cosmic web.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Digitally enabled social district renovation processes for age-friendly environments driving social innovation and local economic development'.

assistant: **Objectives**

Housing policy in Europe is characterised by diversity; there is no single concept of ‘social housing’. In Spain, in the industrial development of the XX century, an extensive workers' housing policy was developed, and many social housing options appeared. The renovation of these districts and the refurbishment of this building typology (post-war privately-owned multifamily) requires heavy investment to alleviate situations of constructive pathologies, lack of energy efficiency and accessibility, and to adapt them to modern standards and the new requirements of their current users (often older people).The core ambition of the project is the development of an integrated renovation methodology aiming to transform social housing districts into inclusive smart neighbourhoods. It will guide constructive, energy and digital updates of neighbourhoods to improve urban space, accessibility and quality of life for all resident, and to guarantee connectivity of these neighbourhoods in physical, social and digital areas.The two drivers around which this project is structured are social innovation and local economic development both sharing the integration of innovative technologies as a guiding thread but with a human-centred approach and fit for purpose. The project will also explore the growth creation potential of cultural and creative industries (CCIs) in these processes of social neighbourhood renewal while strengthening social cohesionBased on an understanding of users’ needs, it will be validated through a use case in one social housing neighbourhood in Ermua (Spain). This process will be enriched by a peer learning method: Ermua will iterate with Elva (Estonia) as digitally advanced, and Matera (Italy), with their experience around the CCIs having been European Culture Capi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Articulatory study of consonant production via epg and ema techniques' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content In the context of a complete understanding of the task of speaking, my main objective is now the study of articulatory dynamics of consonant production particularly the temporal trajectories of articulators such as the tongue. It is now well-known that for the production of consonants, the constriction occurs in a well-defined zone of the vocal tract but it has been shown that the exact position of the contact in this zone can be modified by the vocalic context within which the consonant is produced. To understand details of the influence at vocalic context and to simulate such a phenomenon, the question of the existence of the consonantal target is fundamental: is there for the production of a plosive consonant a spatial articulatory target as proposed for the production of vowels or, if so, then should the task be considered in another manner, for example by the production of a contact between articulators ? This question will be the centre of interest of the post doctoral project that I propose to do at Queen Margaret College. For this, I will record the production of alveolar plosives and fricatives in both French and English and will study the correlation between acoustic and articulatory events. The articulatory data will be acquired with the combined use of Electropalatograph and Electromagnetic Articulograph. The Electropalatographic technique (EPG) provides information about location and timing of tongue contacts with the hard palate and the electromagnetic Articulograph (EMA) tracks the movement, in the mid-sagittal plane, of up to five miniature coils attached to themid-line of the tongue. When used in combination, the two techniques can provide a reasonable representation of the overall shape and configuration of the tongue an