RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Glucomannan : a new vegetal texturising agent for european food and non-food industries' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Glucomannan is an hydrocolloidal polysaccharide consisting of mannose and glucose polymers, obtained from the tubers of various species of Amorphophallus commonly named 'konjac' or'elephant yam'. Konjac glucomannan is a product already widely used in Asian countries and the United States for its unique functional properties (viscosifying action and synergy with other natural gums). Raw material is mainly produced in several Asian countries, without reliable and consistent knowledge in agricultural and process management. The products actually exported to Europe (for diet food and pet food) are rarely of consistent quality and do not meet EU standards for industrial food markets. Having received recently a tentative european agreement number as food additive (E425), the konjac flour will be imported in large quantities. For this reason, a standardised glucomannan european source, contributing to agricultural diversification, will also improve the EU trade balance In order to secure the growing demand from the Western Food and non-food Industries, the proposed project will thus assess upgrading and standardisation of konjac glucomannan by : in EU countries. Knowledge acquired on glucomannan functionalities in formulations. Assessment of crop feasibility and profitability will be achieved through adaptability and agricultural trial in two contrasting EU pedo-climatic conditions. Development of an industrial complete refining process will be undertaken for standardisation of glucomannan quality, up to industrial scale. Setting up of a range of tailor made blends with specific functional properties will be done, after end-uses industrial tests. This market driven project, mainly set up by european skilled private companies including 3 SMES', will thus set-up an integrated ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering and Targeting the Synapses between Cancer Cells and Neurons in Pancreatic Cancer' (SYNAPSE-ON-CANCER).

assistant: **Concept**

The nervous system has recently been identified to play a central role in cancer pathogenesis, and this discovery has given birth to the burgeoning field of “cancer neuroscience”. Neurons and cancer cells outside the brain are known to communicate over paracrine signals, However, we recently discovered direct synaptic connections between sensory nerve endings and cancer cell membrane in a cancer outside the brain, i.e., pancreatic ductal adenocarcinoma (PDAC). These synaptic sites exhibit a selective enrichment of the glutamatergic NMDA receptor subunit GluN2D on the cancer cells, which enables PDAC cells to hijack the neurotransmitter L-glutamate over these cancer-neuron-synapses. This synaptic input not only aggravates tumor invasiveness and spread in vivo, but, surprisingly, also turns synaptically connected pancreatic cancer cells into electro-responsive, excitable cells via GluN2D-type glutamate receptors at the neuro-cancer synapses. Hence, we now have compelling evidence that pancreatic cancer cells are embedded into synaptically interconnected neuron-cancer networks in the pancreas. In the present study, we will perform the first real-time analysis of the emergence, evolution, function, and plasticity of synaptically interconnected neuron-cancer networks in PDAC. We will perform in vivo two-photon imaging focusing on these synapses in novel, human-like models of PDAC, will dissect their molecular operating mechanisms, and will assess the network activity over the neuron-cancer synapses directly in human PDAC specimens, but also in our novel “innervated organoids”. Finally, we will test the translational potential of the targeting this synaptic interconnection of pancreatic cancer cells with neurons in preclinical trials, coupled with in silico drug repurposing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Experimental and numerical study of long runout landslides'.

assistant: **Innovation**

Landslides, the violent motion of large masses of debris, rock or snow, are an ever-present danger in mountainous regions the world over. After the landslide material falls down the mountainside, it will run out some distance away from the mountain even on relatively flat surfaces until the energy it gained from falling is dissipated by friction with the terrain. Although a simple energy balance argument suggests that a single rock cannot travel farther than the height from which it fell, many landslide runouts extend their ruin to seemingly safe distances far removed from their origin. These long runout landslides have baffled scientists for over a century, ever since Albert Heim recorded his study of the Elm rock landslide that devastated the village of Elm, Switzerland in 1881. There are many explanations for this phenomenon, such as lubrication by an interstitial fluid, but none of these satisfactorily addresses how a completely dry landslide can run out so far. Not understanding how and when long runouts will occur makes hazard mitigation and prediction extremely difficult, highlighting the urgency of this issue. Recently, Melosh and coworkers have provided support for a mechanism borrowed from the fluidization of impact craters, “acoustic fluidization”, by using idealized 2D simulations of circular disks, but more work is needed to show that this mechanism is a feature of real 3D flows and robust for a range of conditions. We will perform laboratory experiments and fully 3D simulations of granular flows using simultaneous pressure and velocity measurements to test the acoustic fluidization hypothesis. We will also look for a crossover between this dry mechanism and the lubrication mechanisms for wet landslides. Besides application to landslide engineering, we will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Management of health and environmental hazards' (MANHAZ) under Fifth Framework.

assistant: **Objectives**

The mission of the Centre is to provide leadership, expertise and integration of the activities related to risk assessment from hazard substances in Poland. The main objectives of the Centre are:a) apply advanced scientific approach and technologies in management of environmental risk,b) enhance the combined understanding of multiple health and resource factors and their interrelationships, to better inform decisions made to protect ourselves and our environment,c) become a catalyst for improved environmental decisions through sound risk management,d) enhance a co-operation with domestic and foreign institutions from EU countries and NAS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European Reference Tiled Architecture Experiment' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

EURETILE investigates and implements brain-inspired and fault-tolerant foundational innovations to the system architecture of massively parallel tiled computer architectures and the corresponding programming paradigm. The execution targets are a many-tile HW platform, and a many-tile simulator. A set of SW process - HW tile mapping candidates is generated by the holistic SW tool-chain using a combination of analytic and bio-inspired methods. The Hardware dependent Software is then generated, providing OS services with maximum efficiency/minimal overhead. The many-tile simulator collects profiling data, closing the loop of the SW tool chain. Fine-grain parallelism inside processes is exploited by optimized intra-tile compilation techniques, but the project focus is above the level of the elementary tile. The elementary HW tile is a multi-processor, which includes a fault tolerant Distributed Network Processor (for inter-tile communication) and ASIP accelerators. Furthermore, EURETILE investigates and implements the innovations for equipping the elementary HW tile with high-bandwidth, low-latency brain-like inter-tile communication emulating 3 levels of connection hierarchy, namely neural columns, cortical areas and cortex, and develops a dedicated cortical simulation benchmark: DPSNN-STDP (Distributed Polychronous Spiking Neural Net with synaptic Spiking Time Dependent Plasticity). EURETILE leverages on the multi-tile HW paradigm and SW tool-chain developed by the FET-ACA SHAPES Integrated Project (2006-2009).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Laser-assisted metal spinning for an efficient and flexible processing of nickel- and titanium-alloys' (EASYFORM) targeting Seventh Framework.

assistant: **Abstract**

Due to their high CO2-emissions, the aeronautics industry intends to produce more efficient and environmentally friendly turbine engines using high-strength alloys. As a decisive part of the supply chain, the EU metal spinning industry is increasingly requested to form these challenging materials. To keep quality demands and to stay competitive against new manufacturers in BRIC and other countries, metal spinning companies, which are mostly SMEs, strive for developing new technologies for the production of improved turbine components. One opportunity to meet these challenges is applying laser assistance in order to increase process efficiency, as well as deformation-rate and/or -degree (+25%) while avoiding intermediate annealing steps and thus reducing overall production time and costs by 50%. Hence a consortium of 3 metal spinning SMEs, 2 outstanding RTD-performers with specialized knowledge in laser-assisted forming and materials characterization, and 1 machine tool maker from 4 EU countries will develop laser-assisted metal spinning for an efficient and flexible processing of challenging Ni- and Ti-alloys. EasyForm is built on 1) a design of an industrial applicable laser processing head which is capable of being integrated in conventional spinning machines, 2) machining strategies for laser-assisted metal spinning of aerospace components made of Ti- and Ni-alloys, and 3) a guideline for quality control of components manufactured by the new technology. Subsequently, project results are going to be verified by the manufacture of selected demonstration parts and to be benchmarked regarding technical and economic aspects against competitive technologies. Finally, staff of SMEs is qualified/trained by specific instruction material. Dedicated dissemination activities and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Automated synthesis of S. pneumoniae 7F capsular polysaccharide repeating unit as candidate for conjugate vaccines' (AUTOOLIGO) under Horizon 2020.

assistant: **Objectives**

The goal of this project is to develop an automated synthesis of the Streptococcus pneumoniae 7F capsular polysaccharide repeating unit, which is of high interest for synthetic vaccines against this pathogen. This structural motif has never been synthesized yet, not even by traditional solution techniques. Our approach is highly innovative in the application of automated oligosaccharide synthesis, which will make the synthetic procedure more time- and cost-effective. In the course of the project, a series of orthogonally protected monosaccharide building blocks will be synthesized. The oligosaccharide will be assembled on oligosaccharide synthesizer. Photocleavage in a flow reactor and global deprotection will yield the target molecule. The oligosaccharide will be subjected to bioconjugation with a CRM197 carrier protein to produce conjugate vaccine candidate. This conjugate will be tested for the ability to induce an immune response against S. penumoniae 7F.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Auctions with Investments: Timing and Information' to be submitted under Seventh Framework.

assistant: **Abstract**

Auctions are important and widely used trading mechanisms. Bidders often undertake investments in relation to an auction they participate in. For example, firms may invest in research and development prior to bidding for public procurement in order to reduce their costs or improve the quality of the goods and services they are offering. The main objective of the proposed research project is to further understand bidders’ incentives for these types of investments and how these incentives interact with the auction rules, and the consequences in terms of efficiency and the seller’s revenue (or the cost of procurement). This understanding will have both theoretical and practical implications in terms of auction design. The project will also be a contribution to the endogenous entry literature.One of the distinguishing features of the project in comparison to the previous literature is allowing firms to have private information at the time of investment, which is quite natural, as firms know more about their own profitability than their competitors. Second, the question of the timing of investments will be addressed, since firms can invest after as well as before the auction. Finally, the issue of observability of investments (at the auction stage) will be tackled. In this general framework, it will be possible to study the firms’ incentives to invest and investigate the performance of commonly used auction formats in terms of efficiency and the revenue of the seller under various specifications. In addition, optimal auctions will be studied using the mechanism design approach.The proposed research project is theoretical. It also aims to help future empirical studies of investments and entry in auctions. It will also be of interest to policy makers, given that auctions are c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Protein kinases - Novel Drug Targets of Post Genomic Era' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Nearly all aspects of cell life (and death) are controlled by protein phosphorylation catalysed by protein kinases (PKs). PKs belong to the largest single family of enzymes, numbering over 500 and accouting for almost 2% of the proteins encoded by the human genome. Recent success in drug discovery (e.g. Imatinib, GlivecR) demonstrate that PKs are excellent drug targets. The Pro-KinaseResearch consortium will combine European expertise on basic research on PKs and that on rational drug discovery, in order to develop new drug candidates and treatment strategies for major diseases like cancer, autoimmune disorders, vascular diseases and degenerative brain diseases. Thus, the aim of this IP is to study PKs as drug targets for more effective and better tolerated drug therapies meeting the needs of ageing population.The joint effort will focus on the biochemical properties and structure function relationships of a wide variety of PKs having the potential as pharmacological targets. We will evaluate the regulatory domains, catalytic domains and also anchoring proteins of various PKs, as drug targets. Natural compounds from European biosphere, e.g. Cyanobacteria, and compounds from combinatorial chemistry, chemical libraries, affecting activity of PKs will be analysed to gain knowledge of their structure/activity relationship. These compounds will be used as model drugs or templates for a rational drug design where new compounds will be modelled and synthesised. This consortium has a broad range of bioactivity assays to study the efficacy and toxicity of the new compounds. The consortium includes academic groups with unique expertise in biochemistry, structural crystallography, synthetic organic chemistry, lead structure optimisation and other fields of rational drug discovery;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Southern urals radiation risk research' to be submitted under Sixth Framework.

assistant: **Abstract**

The aim of the SOUL project is to quantify risks of late health effects associated with low-dose rate exposure to plutonium, strontium and external gamma radiation. This will be done by improving, updating and analysing dosimetric and health data for the Mayak worker cohort (MWC), the extended Techa River cohort (ETRC) and the Techa River offspring cohort (TROC). Key dosimetric elements include electron paramagnetic resonance (EPR) measurements of tooth enamel, photon spectra measurements, luminescence measurements of absorbed doses in bricks, measurements of strontium distributions in teeth, fluorescence in-situ hybridisation (FISH) measurements of chromosome aberrations, and modelling of internal doses of foetuses and infants. The dosimetric work aims to produce updated dose data bases Mayak Doses 2008 and Techa Doses 2008. In order to increase statistical precision and validity, the number of individuals in the cohorts will be extended, and information on vital status and cause of death will be updated. In the TROC, cancer and cardiovascular disorders will be studied as late health effects following exposure early in life. Non-cancer effects will be studied in the ETRC. The pathogenesis of lung cancer in the MWC will be studied in order to improve the current knowledge. The MWC will be used to study cancer incidence, and mortality and morbidity of circulatory diseases such as myocardial infarction and stroke. In the studies, initial feasibility analyses will be followed - if affirmative - by analyses that are based on longer follow-up and dosimetric data bases improved within the framework of SOUL. Although SOUL is expected to give significant input to the understanding of radiation risks, Southern Urals radiation risk research has to be tinued beyond the project mai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'TOWARDS A SUSTAINABLE AND PRODUCTIVE DOUGLAS-FIR FOREST OF HIGH QUALITY RAW MATERIAL IN EUROPE. EUROPEAN DOUGLAS-FIR IMPROVEMENT RESEARCH COOPERATIVE' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Introduced in Europe during the mid 19th century Douglas-fir (Pseudotsuga menwiesii Mirb. Franco) represents now, since several years, a major species used in reforestation. This increasing integration of Douglas-fir in the European forestry is explained by its exceptional qualities, from economical and ecological point of views : great adaptability to various environments? very fast growth : wood production of high quality, freedom of sever pest and disease, quick canopy closure allowing the development of a deep soil litter, no risk of genetic pollution, since it cannot hybridise with any native European species.The objectives of the project are :1- to study how genetic diversity is impacted after acclimation to various european environmental conditions and after natural regeneration; to manage existing genetic resources in Europe (natural resources are threatened of disappearing in the natural range), thanks to a common database; to expend the European Douglas-fir progeny test network;2- to synthesize IUFRO provenance information; to collect measurements in the  large E.U. co-operative network of tests comparing more than 1000 open-pollinated progenies originating from elite natural stands.  These measurements will allow to better understand the factors involved in  Douglas-fir adaptability, and therefore sustainability. It is an approach to define large ecological zones in Europe in regards to adaptation of genetic materials and  co-operatively share the Douglas-fir breeding programme in E.U.;3- to understand the environmental and genetic control of forking and branching  defects, frequent in Douglas-fir and considerably reducing the value of the final product; to evaluate the ability of Douglas-fir for industrial uses for wich little information exists: peeled vene