RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optical strategies to investigate NMDA receptor functional diversity and its therapeutic potential' in the context of a Horizon 2020 call.

assistant: **Objectives**

NMDA receptors (NMDARs) form a class of receptors gated by glutamate, the major neurotransmitter in the mammalian brain. These receptors play fundamental roles in synaptic transmission and plasticity. They are also involved in numerous pathologies including stroke, mental retardation or schizophrenia. NMDARs are thus targets of strong therapeutic interest. NMDARs are tetramers usually composed of two GluN1 and two GluN2 subunits encoded by four different genes (GluN2A-D), resulting in a large number of receptor subtypes having distinct anatomical, biophysical, pharmacological and signalling properties. Understanding the functional role of these individual subtypes in the brain is of great importance to develop new strategies to counteract the deleterious effects of NMDAR dysregulation. However, tools allowing targeting of a specific population of NMDARs in a given neuronal circuit are currently lacking. The OptoNMDA research programme proposes the development of an innovative optical approach to selectively enhance the activity of NMDARs containing the GluN2B subunit (GluN2B-NMDARs) in ex vivo and in vivo preparations. This approach consists in developing photo-convertible polyamine derivatives that can reversibly isomerize between an inactive and active configuration with light to act on the GluN2B-NMDAR polyamine allosteric modulating site in a precise spatio-temporal manner (opto-allostery). I will study the physiological and potential therapeutic roles of these compounds by testing their effects on synaptic transmission and plasticity and on genetic models of NMDAR hypo-function. Compared to previous studies targeting orthosteric (competitive) sites, the opto-allostery approach will allow manipulation of NMDARs in a more specific and physiological manner. This proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The AI-based intelligent assistant for dairy farmers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Milk is an important nutrient globally: 6bn+ people worldwide consume milk and milk products. In Europe milk provides 11-14% of dietary fat supply. Today we already have 274m+ dairy cows, doubling their headcount to serve the global need for milk is not sustainable.Health & well-being of cows are the main factors responsible for the difference in cow’s milk production.  However, to improve the cattle health, the dairy farmer has to watch every single animal non-stop, 24x7, which means an unaffordable increase of at least 30% in labour costs. To address this challenge we have developed Ida, the world’s first dairy farmer’s assistant that uses artificial intelligence (AI) to learn the behaviour of cows & generate useful operational insights for the farmer.on how to improve animals’ health & improve productivity.Ida combines sensor technology, machine learning & cloud computing to translate raw data from the field into meaningful information that can be used to support decisions made by farmers every day. Unlike existing cow movement trackers that simply relay motion data to a central collection point, we have built Ida as a system that carries out intelligent pattern analysis.By observing & learning how the cows behave, and by benchmarking the farm’s performance against the most efficient farms globally, Ida provides clear recommendations to the farmer.In our feasibility assessment we have calculated that Ida will help farmers increase productivity per animal by 22%+. We have first market traction: as of Jan 2018 Ida is already monitoring 2,000+ cows globally. With Ida in we are aiming at an annual market opportunity of at least €385m by 2023 from the overall €1.4bn global market for connected cows. In this Phase 2 project we are requesting a €1.7m contribution to industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis and photopolymerisation of new fluorinated macromonomers for the obtaining of high performance fluoropolymers' (PhotoFluo), addressing dissemination and exploitation.

assistant: **Impact**

The PhotoFluo project consists in a consortium of three teams (two from Europe and one from Canada) committed to work for developing novel fluoropolymers suitable for optical and electronic devices, membranes for fuel cells and Li batteries, microfluidics, and biomaterials. This ambitious goal will be achieved starting from designing new perfluoropolyalkylether building blocks (PFPAE) improving safety (not bioaccumulative like perfluoroalkylics) and having chemical inertness, flexibility in a wide temperature range, very low refractive index and wettability. PFPAE will be chain extended to tune final properties; exploiting OH functionalities, these precursors will be functionalized to make telechelic macromonomers for suitable crosslinking (via both radical and ionic processes). The polymers will be synthesized by photoinduced polymerization, chosen as an efficient and eco-friendly process: the polymer formation is fast (no more than minutes compared to hours requested by thermal processes), is solvent free, is carried out at room temperature consuming low amount of energy, permits spatial resolution, as it mainly occurs in the illuminated areas. After obtaining an original portfolio of PFPAE polymers, they will be fully characterized and tested in view of innovate applications. The project is conducted by research groups with a relevant scientific record in the fields: (i) fluorochemistry (TWU, Canada), (ii) photopolymerization (iii) polymer science (POLITO, Italy and ENSCM, France). The combination of expertises makes the objective  feasible. For the implementation of the program, 24 secondments are planned to exploit the complementarities of the different expertises of each groups, to share them and to reinforce young researchers career.  The project  includes a stro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Implementation of a smart RETROfitting framework in the process industry towards its operation with variable, biobased and circular FEEDstock' (RETROFEED), addressing dissemination and exploitation.

assistant: **Impact**

RETROFEED main objective is to enable the use of an increasingly variable, bio-based and circular feedstock in process industries through the retrofitting of core equipment and the implementation of an advanced monitoring and control system, and providing support to the plant operators by means of a DSS covering the production chain. This approach will be demonstrated in five resource and energy intensive sectors (ceramic, cement, aluminium, steel, and agrochemical) with the potential to reach in average an increase of 22% in resource efficiency and 19% in energy efficiency, with a consequent reduction in costs and GHG emissions of 9.3 M€ and 135 kton CO2 respectively.Furthermore, the project aims to develop a methodology to support retrofitting in resource and energy intensive industries that will be complemented by a decision support system able to perform a diagnosis of the impact in the process of different retrofitting solutions so plant managers and operators can decide on the most suitable retrofitting action for their companies. This decision support system will remain operative after the modification of the process so it can ease the operation of the process under the increased variability of feedstock by analysing a set of key indicators defined within RETROFEED over the production chain for this purpose.RETROFEED consortium comprises strong industrial participation; 9 large companies, including 5 of them as final users, and 4 SMEs as technology providers, working with experienced RTOs and supporting entities. The private investment associated to RETROFEED is over 7M€ along the execution of the project. Lastly, RETROFEED is expected not only to enable technological advances in the technologies and demonstrators involved but will also contribute to the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechano-modulation of tumor microenvironment with mechanotherapeutics and sonopermeation to optimize nano-immunotherapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Inefficient drug delivery to tumors can reduce dramatically treatment efficacy and thus, affect negatively the life of cancer patients. This is particularly evident in desmoplastic cancers where interactions among cancer cells, stromal cells and the fibrotic matrix cause tumor stiffening and accumulation of mechanical forces that compress tumor blood vessels. Indeed, in subsets of pancreatic cancers and sarcomas, 95% of intratumoral blood vessels may be compressed and up to 80% totally collapsed leading to reduced blood flow (hypo-perfusion) and drug delivery. Hypo-perfusion also leads to hypoxia that helps cancer cells evade the immune system and increase their invasive and metastatic potential. Use of mechanotherapeutics and ultrasound sonopermeation are two mechano-modulation strategies that separately have been employed to treat vascular abnormalities in tumors. Even though these strategies have reached the clinic, their promise has yet to be realized by cancer patients owning to limitations of the methods. My hypothesis is that these strategies can uniquely complement each other and have not only additive, but highly multiplicative synergistic effects on modulating the desmoplastic tumor microenvironment and improving the efficacy of the promising but still of limited use nano-immunotherapy. However, it is crucial that specific guidelines should be developed. To achieve this ground-breaking goal, I will employ a mixture of cutting-edge computational and experimental techniques. I will perform in vivo mice studies in pancreatic cancers and sarcomas to investigate under what conditions these mechano-modulation strategies can be optimally combined to improve treatment efficacy, prevent metastasis and increase survival. In parallel, I will develop new mathematical mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of 2nd Generation Biorefineries – Production of Dicarboxylic Acids and Bio-based Polymers Derived Thereof' (BIOREFINE-2G) targeting Seventh Framework.

assistant: **Abstract**

The existing 2nd generation biorefineries utilize less than 20% of the biomass feedstock for ethanol production, and major side-streams are produced such as pentose and lignin waste streams, that are respectively used for biogas and energy production. Converting the carbon from these waste streams into added-value products would increase the otherwise low profitability and improve the environmental benefits of the biorefineries. The suggested project BioREFINE-2G aims at developing commercially attractive processes for efficient conversion of pentose-rich side-streams from biorefineries into dicarboxylic acids, which can be used as precursors for bio-based polymers including biodegradable polymers.The project covers the whole value chain, from characterization of side streams from forest and other non-food feedstocks, development of novel robust industrial yeast cell factories, fermentation and downstream process development, to polymerization methods development for the production of biodegradable polymers applicable as plastics, coatings or adhesives, scale-up and demonstration and to life cycle and economic viability analyses.The consortium involves eight distinguished industrial and academic partners within the biotechnology, directly targeted by the call. The strong industry drive is ensured by participation of 4 SMEs and 1 large enterprise, Borregaard biorefinery, which is directly interested in demonstrating and integrating the new technology into the current and future biorefinery plants. All industry partners will assure demonstration activities and investigate the technical, environmental and commercial feasibility of the new process with regard to scale up to industrial production.Overall, an innovative process for bio-based chemicals production from bio-wast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Research and development of a new process to extend the lifespan of concrete structures by natural desalination and realkalization' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objectives of this project have been met. Tasks 1 and 2 have permitted to propose and select, after an impressive series of tests on concrete samples, the best couple anode-electrolyte. Samples of anode materials with various densities have been produced. Best results for chloride extraction and realkalisation were obtained with the following couple 9Al/AlMg3/NaOH 2M.The principles of the data acquisition system and of the regulation equipment have been set up in Task 3. This system will permit to monitor the loss of water in the paste and re-humidify it to restore an efficient galvanic current. Task 4 has investigated the secondary effects of the treatment on structures potentially reactive to ASR. No effects were recorded on carbonated concrete; However a treatment on fully chloride contaminated structures would induce a significant ASR expansion.A specific application pump and extrusion devices have been developed and successfully tested within Task 5. Also a polymer modified cement-based coating has been tested. It reduces significantly further ingress of CO2 and chloride after treatment.Finally, Task 6 was scheduled to work on proposed European standards. The last draft of prEN 14038 includes now recommendations on electrochemical treatment of reinforced concrete by using galvanic current.The main goal of this protect is to develop a new process, easy to apply, which creates at the same time a desalination, or chloride extraction and a realkalisation of the concrete. This research will help to preserve reinforced concrete structures of deterioration due to corrosion of steel reinforcement since the corrosion mechanism is directly linked with the depassivation of concrete (carbonation) and the ingress of chlorides (due to deicing salts for instance). It will per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'G9 GO FOR THE MISSIONS!' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The G9 GO FOR THE MISSIONS (G9MISSIONS) will be our 3rd experience as a consortium in managing the European Researchers Night in Spain, covering 40% of the Spanish territory. University of Cantabria will be the coordinator of a team composed by eight Spanish universities acting as beneficiaries. The overall initiative will be centred on the five European research and innovation missions that aim to deliver solutions of the great societal challenges facing our world (climate-neutral and smart cities, adaptation to climate change, cancer and healthy soils and water). G9Missions will promote awareness and encourage them to find solutions together to make a real difference. Engaging activities will be designed to show the policies that are behind these missions, namely the European Green Deal, Europes Beating Cancer Plan as well as the Sustainable Development Goals. The project consists of two main events to be held on September 30th in 2022 and September 29th in 2023, three pre events open to general public, Researchers at school activities distributed throughout the two years focused on pupils in schools and two post events as wrap-up meetings to analyse the impact. Pre-events will be celebrated on World Environment Day (5th June), World Cancer Day (4th February) and World Oceans Day (8th June), each with a main activity coordinated by different partners. Researchers at school activities will be part of a programme denominated Circular Science based on activities with innovative methodology and involving the whole school community. A Mission Book and a school certification after completing all missions will be some assets to promote participation. STEM fields, RRI principles, gender management and Open science practices will be widely covered, The European dimension will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Smart Nanoreactors for Enhanced Electrochemiluminescent Biosensing' (NANO-BOOST).

assistant: **Concept**

Electrochemiluminescence (ECL) is luminescence driven by electrochemical reactions, offering unparalleled spatiotemporal control and exceptionally low background noise compared to other optical methods. Over the past two decades, ECL has become a powerful analytical tool, revolutionizing areas ranging from fundamental research to clinical diagnostics, biosensing, and biological applications. Despite these significant advancements, understanding the fundamental mechanisms behind ECL remains a complex and ongoing challenge. Creating confined reaction environments at the nanoscale offer a promising tool to unlock new insights into ECL mechanisms. Key questions in this context are: i) Can we establish a connection between the design of nano electrodes and their nanoconfinement performance in ECL?  ii) Can such a connection be a tool capable of simulating various ECL reactions to optimize reaction parameters? iii) Can this model help identify the optimal microenvironment to maximize ECL efficiency?NANO-BOOST will answer these questions by exploring the combined effects of nanoscale geometry and surface chemistry on ECL efficiency with the goal of developing advanced smart ECL Nanoreactors (ECL-NR). Using high-throughput nanofabrication techniques that enable precise control over surface topography and chemistry, NANO-BOOST will bridge the gap between material science and chemistry, creating new synergies to accelerate the discovery of new aspects of ECL mechanisms.  NANO-BOOST will establish a definitive correlation between nanostructure design, nanoconfinement, and reaction parameters, thereby pinpointing the optimal conditions to maximize ECL efficiency within specific analytical contexts. These discoveries will contribute to the advancement of high-performance ECL sensing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'RECALL: Enhanced Human Memory' (Recall).

assistant: **Concept**

RECALL aims to re-think and re-define the notion of memory augmentation. Recent developments in capture technology and information retrieval allow for continuous and automated recordings of many aspects of our everyday lives. RECALL will harness these trends and develop a new paradigm for memory augmentation technologies that are technically feasible, desired by users, and beneficial to society. By combining technological interventions with basic research questions in memory psychology, we plan to elevate memory augmentation technologies from a clinical niche application to a mainstream technology, initiating a major chance in the way we use technology to remember and to externalize memory. RECALL will build on contemporary memory theories that highlight how technology augmented recall can be used to both re-enforce and attenuate memories. It will develop novel capture technologies and corresponding control mechanisms to automate the acquisition of personal memories, and investigate how feedback through ambient large displays and personal mobile devices can aid personal memory acquisition, retention, and attenuation. The project is highly innovative – no such memory augmentation systems exist today and their emergence would represent a radical transformation in the way we understand and manage human memory acquisition and recall. The project is high risk – numerous technical and societal challenges need to be addressed before augmented memory systems are possible; and potentially high pay-off – if successful, the project will contribute to our fundamental understanding of human memory and have a transformational impact on all spheres of life – the workplace, family life, education, and psychological well-being – by measurably improving the acquisition of new knowledge,