RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HELICITY: Evolution of correlated traits in response to city life: helicid snails as windows on the consequences of urban history' (HELICITY).

assistant: **Innovation**

Urbanization is one of the most dramatic land-use changes caused by humans, combining habitat fragmentation and loss, pollutions and increased temperature. While it causes numerous population declines in many species, others persist or even thrive in cities, possibly through evolutionary changes. In this project, I will study how urbanization shapes multivariate phenotypic evolution in such an organism, including not only life-history traits, movement strategies/space use… but their association into integrated phenotypes. As a central point, I will explicitly consider the oft-neglected temporal heterogeneity/ history of the urbanization process, comparing new and older urban neighbourhoods to see under which conditions organisms can adapt to city life fast enough. Using snails as models, this Action will combine advances in small animal tracking, statistical analysis and data science with state-of-the-art evolutionary ecology, to not only explore the mechanisms behind observed changes, but also potential consequences for relevant aspects of ecosystem functioning. This project will increase our understanding of the ecological consequences of evolution in response to human-caused environmental changes, helping fill major knowledge gaps noted by the IPBES. Through outreach, it will increase community engagement with (urban) biodiversity. Finally, by merging two of my long-standing research lines in a common, integrated project, through the acquisition of new scientific skills and training in project management, it will favour my establishment as an independent leader in the field.


**Keywords:** climate change,  dispersal,  functional ecology,  quantitative genetics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultra-efficient Multi-phase Sequential Waste Water Treatment Technology' (Anaergy) under Horizon 2020.

assistant: **Objectives**

The agro-food industrial sector is required to treat large quantities of wastewater (20,000 l /product kg) rich in organic matter content (30 kg Chemical Oxygen Demand – COD – per m3 wastewater). Anaerobic digesters treat high COD wastewater and produce biogas used as a renewable energy source. Nevertheless, even the most advanced high-rate systems present important technical and economic limitations: 1) Post-treatment (usually aerobic) is still required for wastewater discharge on surface water (COD elimination rates are in the range of 60-80% for current technologies), 2) Digester investment costs are high (€300,000 for the smallest reactors), 3) The efficiency of biogas production is low (35-50%). The above confirms that the industry is on demand of low price digesters and high efficiency biogas production solutions that will increase COD elimination rates. Through the launch of ANAERGY, Ingeobras and Proycon consortium aim to respond to these demands by introducing a proprietary Multiphase Sequential Anaerobic Digester, being the first demonstrated solution able to combine anaerobic, aerobic and photocatalysis in one digester. Our current prototype was built in-house and has been tested under relevant industrial conditions in 4 pilot plants, offering very high COD elimination rates (up to 99.8%) allowing for direct discharge to the land and a 60% increase in biogas production efficiency. At a low price (€150,000) and with very low operational cost we are offering a extremely efficient solution for the agro-food industry to treat water without need of post-treatment (60% reduction in operational costs). Furthermore, the production of biogas will cover industry energy needs up to 80%, enabling a return of investment of 12-20 months. We target commercialisation by 2021
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Up-Skilling for Industry 5.0 Roll-Out' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The 4th Industrial Revolution/Industry 4.0 has enabled reduction of production costs, improved consistency of product quality and enabled mass customisation by merging the physical and digital worlds. The transition is still ongoing - Industry 4.0 is a general-purpose technology, adding value across all industrial sectors. However, the perception of Industry 4.0 at a human level has not all been positive. It has been plagued by fear of job cuts and in some sectors completely replacing the human workforce. Automation projects have often failed due to omitting the critical skilled human elements in business success with unintended consequences including reduced customer satisfaction, poorer product quality and lower process efficiency. Automation alone clearly cannot be a source of sustained competitive advantage. I5.0 will address the balance between humans and technology, focussing on the collaborative relationship between skilled workers and automation. The intent is reinstate skilled craftsmanship at the centre of production processes where people add unique value and competitive advantage, augmented by intelligent, data-driven technology emerging from Industry 4.0.In the Up-Skill project, we will address the implications of Industry 5.0, in particular the relationship between automation, skilled work and organisational systems. Our research will establish how the relationship between automation and human input plays out in a range of industrial settings, creating comparative case studies to capture effective implementation strategies. We will address under-explored strategic spaces in production - where automation adds value to skilled and artisanal work, and where further automation risks undermining product value. This research will identify the shifting organisati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Immune diagnosis of dirofilariasis infections in humans and animal reservoirs, and protection in animals' (1994-1998).

assistant: **Innovation**

Dirofilariasis is a parasitic zoonosis caused by Dorofilaria immitis, a nematode belonging to the family Onchocercidae. This parasitosis affects dogs and cats which act as reservoirs, and occasionally humans in whom it could originate benign pulmonary nodules that can be mistaken for pulmonary carcinoma. Dirofilariasis is a public health problem and its control requires diagnostic and protective measures. Because products of this nature do not exist in the market, the constitution of a European industrial/university team for their production would constitute a great opportunity for pre-empting the American industry in this field. The objectives of the proposal are: Identification of antigens of diagnostic/protective interest. 2. Cloning genes related to these antigens. 3. To probe the diagnostic/protective capacity of the recombinant antigens. This research has a pre-competitive character and its objectives are in accordance with those of the BIOMED Programme. An important technical advantage can be achieved if these products are manufactured, because: they will occupy an unexploited space in the market , the improvement of the current methods could be achieved and they will contribute to the improvement and reduction in costs of the health services. The selected tasks for the exploratory phase are related to the development of the proposal (the search for new partners; verification of the originality of the research and the evaluation of the economic impact), and to the study of the viability of the proposal (identification of polypeptides of interest and genes related to them in a cDNA expression library of D. immitis).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A new methodology based on an advanced molecular probe for early detection of DPD enzyme deficiency in oncological patients, also enabling a personalised and effective drug management""' (CARESS), addressing dissemination and exploitation.

assistant: **Impact**

Amongst all the chemotherapy agents, 5-FU (fluorouracil) is being in use since 40 years, and is one of the most successful and widely employed in the treatment for breast, colon, and skin cancer, three of the most frequently occurring malignant tumours. In general, 5-FU is relatively well tolerated at standard doses, but there are some important issues that must be duly taken into consideration: 1)Around 8% of patients manifest a genetic variation that leads to a deficiency of an enzyme called Dihydropyrimidine dehydrogenase (DPD) that is crucial for the metabolism and deactivation of 5-FU. This causes several toxic reactions like mucositis, diarrhea, neutropenia, cerebellar ataxia, cerebellar dysfunction, and can even be fatal at the very first dose of 5-FU, with  a mortality rate of about 0,5%. About 30% of patients suffer from severe toxicity effects after being treated with 5FU. Despite many approaches have been proposed for DPD deficiency screening, none of the current strategies are adequate to mandate routine DPD testing prior to starting a 5-FU based therapy. The CARESS project proposes to implement the first, compact, cheap, accurate and standard system for measuring the DPD activity level, thus allowing for fast screening of DPD deficiency and for real time adjusting the therapy administered to the patient through a pharmacokinetic approach, allowing to maximise the therapeutic efficacy, abating the costs associated to the management of the therapy and, most importantly, to limit the dangerous side effects for the patients. The system will take as input a small blood sample and will rely on the chemical interaction between a 5-FU analogous chemical probe with the sample, which will release in the solution ions that can be easily detected and measured through o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Electricity market Hawkeye - An online surveillance tool to detect distortions in the supply-side of electricity markets'.

assistant: **Objectives**

While electricity is a basic commodity that underpins industrialization, progress and the quality of life of human beings, its production, storage and transmission is strongly constrained by physical laws and its demand is utterly inelastic. All of this together exacerbates the vulnerability of a sector that is vital to modern societies. A critical and vulnerable sector is not only easily affected by external supply shocks, but also susceptible to manipulation and abuse. Spurred by the conviction that Science must serve the people, in this project we plan to develop and demonstrate the efficacy and usefulness of a tool to automatically alert about atypical distortions in the supply-side of electricity markets, such as those caused by the exercise of market power by energy companies with a dominant position. The tool combines such features that make it unique and the only one of its kind: it runs online and automatically, is purely data-driven, only fed with publicly available information, computationally cheap and able to learn and explain the context under which the distortion is more likely to occur. The scientific heart of the tool is Functional Statistics, and to build it, we will exploit novel notions and techniques for the identification of functional outliers that we developed within the framework of the ERC-STG project FlexAnalytics – Advanced Analytics to Empower the Small Flexible Consumers of Electricity. Our ambition is to equip market regulators and operators with a powerful instrument that not only brings benefits in terms of money saved for consumers, reduced time and effort in supervision and monitoring, and shorter delays in detecting potential offenders, but also and above all, allows regulators to fulfill their most sacred obligation more effectively
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Discrete Optimization in Computer Vision: Theory and Practice'.

assistant: **Innovation**

This proposal aims at developing new inference algorithms for graphical models with discrete variables, with a focus on the MAP estimation task. MAP estimation algorithms such as graph cuts have transformed computer vision in the last decade; they are now routinely used and are also utilized in commercial systems.Topics of this project fall into 3 categories.Theoretically-oriented: Graph cut techniques come from combinatorial optimization. They can minimize a certain class of functions, namely submodular functions with unary and pairwise terms. Larger classes of functions can be minimized in polynomial time. A complete characterization of such classes has been established. They include k-submodular functions for an integer k _ 1.I investigate whether such tools from discrete optimization can lead to more efficient inference algorithms for practical problems. I have already found an important application of k-submodular functions for minimizing Potts energy functions that are frequently used in computer vision. The concept of submodularity also recently appeared in the context of the task of computing marginals in graphical models, here discrete optimization tools could be used.Practically-oriented: Modern techniques such as graph cuts and tree-reweighted message passing give excellent results for some graphical models such as with the Potts energies. However, they fail for more complicated models. I aim to develop new tools for tackling such hard energies. This will include exploring tighter convex relaxations of the problem.Applications, sequence tagging problems: Recently, we developed new algorithms for inference in pattern-based Conditional Random Fields (CRFs) on a chain. This model can naturally be applied to sequence tagging problems; it generalizes the popular C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MULTIPLE USE OF LOW TEMPERATURE GEOTHERMAL WATER IN ERGING' under Fourth Framework.

assistant: **Concept**

The aim of the project is the use of geothermal water for district heating and reclamation of drinking water. The thermal water is produced by a former gas exploration borehole which has been equipped for geothermal water production. The heat requirements are 17 MW with an annual energy amount of 48.300 MWh. The supplied areas are residential areas, recreation areas, a hospital, different schools etc..For the geothermal heat production, about 552,000 m3 geothermal water, cooled down from 65 deg. C to 17...23 deg. C will be used. The cooling process includes primary heat exchange and cooling work by a heat pump.By using an two step-absorption heat pump with water-lithiumbromide, the energetic results are as follows :used geothermal energy : 24650 MWH/Tat a maximal flow rate of : 24 kg/sand a fluid temperature of 65°CThe use of absorption heat pump is technically feasible. For an high heating efficiency, the heat pump is designed for two-step-operation. In the annual average the efficiency is about 1.70 to 1.00. In peak times the efficiency rises up to about 2.2 to 1.Compared to conventional supply with use of fossil fuels, an amount of 28,999 MWh/y of fossil energy or 51% will be substituted by the energetical use of the thermal water.In the next few years, the extracted thermal water (552000 m³/y) will be used as drinking water.In future it will be used as drinking water and as thermal bathing water.The purification of the thermal water will be done by a degassing-plant and a following two-step ozoning and filtration process.The purified thermal water will be mixed with other drinking water in a proportion of max.66.7 to 100 and fed into the drinking water supply of Erding.Installation of the former gas exploration borehole with a capacity of about 55 l/s thermal water
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'SYNTHESIS, CHARACTERIZATION, STRUCTURE AND PROPERTIES OF NOVEL BIODEGRADABLE POLYESTERS'.

assistant: **Objectives**

BIODEST (Synthesis, Characterization, Structure and Properties of Novel Biodegradable Polyesters) Research and Innovation Staff Exchange (RISE) project aims to strengthen around student and staff exchanges with the aim to improve skills and knowledge of the participating partners and promote collaboration between four European Research organizations: University of the Basque Country (Spain), University of Mons (Belgium), University of Genova (Italy), and University of Warwick (U.K.) and five non-EU Research Organizations: University of Tulane (USA), Chinese Academy of Science (China), Simon Bolivar University (Venezuela), University of Stellenbosch (South Africa), and Yamagata University (Japan). Moreover the non-academic European organization “Ma+D - Waste Valorization Engineering” will collaborate in the networking activities. The project will provide support for the participating research organizations to establish or reinforce long-term research cooperation in the topic of novel biodegradable polyesters through a coordinated joint programme of exchange of researchers for short periods.


**Keywords:** Biodegradable polyesters, biobased polymers, crystallization, morphological characterization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fate of mammary stem cells during tumorigenesis and clinical implications'.

assistant: **Innovation**

One of the most challenging questions in breast cancer biology is to elucidate the origin of tumor heterogeneity and its contribution to therapy failure. Accumulating evidence suggests that the cell-of-origin, the cell that acquires the first oncogenic event, may define the molecular portrait of the resulting tumor. The fate of mammary Stem Cells (MSC) upon oncogenic perturbation has been poorly explored. Moreover, the Phosphoinositide 3-kinase (PI3K) pathway regulates proliferation/differentiation of MSC and is found hyperactive in breast cancer cells, for example through mutations in PIK3CA, the gene coding for its catalytic subunit. I hypothesize that expression of PIK3CA mutations will perturb mammary tissue homeostasis, initiate mammary cancer and trigger formation of stem-like cancer cells. Using state-of-the-art in situ genetic lineage tracing, I will determine the fate of MSC (identified recently as Procr+ cells) after conditional expression of PIK3CA hotspot mutations (H1047R, E545K). I will also characterize early molecular events responsible for promotion of transformation (Aim 1). When tumors develop, I will determine tumor phenotype and eventual progression to metastasis (Aim 2). Consequently, this study will generate a new mouse model of breast cancer that will be useful for preclinical studies. A panel of PI3K inhibitors is currently under Clinical investigation and clinical reports have shown that the combination of standard chemotherapy with PI3K inhibitors reduces tumor growth but drug-resistance often occurs. To identify resistance mechanisms to PI3K inhibitors, I will generate in vivo models of drug-resistance (Aim 3). My studies will use both hypothesis driven and unbiased approaches, they should: 1. better elucidate transformation of MSC and the re