RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New molecules in mood disorders: a genomic, neurobiological and systems approach in animal models and human disorder' (NEWMOOD) under Sixth Framework.

assistant: **Objectives**

Depression is common and affects twice as many women as men. In the global burden of disease survey, it is the fourth most prevalent cause of disability, greater than eg cardiovascular disease. Gender, social and familial factors increase risk for depression, but little is known about how these influences work in the brain, least of all at the molecular level. Newer antidepressant treatments still act in the same way as 30 years ago and their downstream molecular actions are obscure. At most 65% of new episodes respond to drug-treatment and chronic, treatment-resistant depression is a major health burden.This is a major collaboration between 13 clinical and basic science groups in 10 EU countries whichaddresses the evident need to discover:New molecular mechanisms in the causation of depression.New molecular mechanisms of effective drug-treatment.We will measure three fundamental processes underlying depression - the inability to experience pleasure, excessive sensitivity to stress and negative appraisal of circumstances. This will enable us to cross-validate findings, in humans and animal models. In animals we will use a mixture of well-established and novel methods for inducing genetic and mild stress-related changes in the three processes. We will detect the molecular mechanisms involved by creating the NEWMOOD microarray chip and measuring changes in gene expression. Changes which are consistent across many models will become targets for new treatments. In addition we will search for neurochemical changes in how monoamine and other neurones are regulated which are shared by the models. These too will become new molecular targets.Humans with varying genetic and environmental risk factors will be compared on the three behaviours and on the brain systems and neurotrans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'ECONOMICAL AND SUSTAINABLE PAVEMENT INFRASTRUCTURE FOR SURFACE TRANSPORT'.

assistant: **Objectives**

With increasing oil prices the future of asphalt roads on deep foundations is less certain, due to increased costs as well as political and environmental concerns. Alternative concrete bases can reduce the foundation layers and decrease or eliminate the asphalt topping. Concrete bases are in general more expensive but are used in heavily trafficked sections and to reduce maintenance. Concrete bases require reinforcement in the form of steel mesh. Premixed fibre reinforcement can replace the mesh and could enable the use of existing asphalt laying machines to lay the concrete. Fibre reinforcement is normally derived from virgin wire, but recent work has shown that tyre fibres offer an attractive low cost alternative solution. Recycled aggregates, PFA and low energy cements will also be employed to reduce costs and energy input. The proposed project will develop infrastructure for surface transport using slip forming techniques based on existing asphalt laying equipment and steel fibre reinforced concrete. The benefits of the new construction concept will be manifold, such as to reduce construction costs by 10-20%, reduce construction time by 15%, reduce the energy consumption in road construction by 40%, minimise maintenance, use waste materials in road construction and make tyre recycling more economically attractive. To achieve its objectives the project draws expertise from 5 countries and will have to overcome serious scientific and technological barriers in fibre processing, concrete manufacture and road design. The project will deliver new processes, design guidelines and full-scale demonstration projects in three diverse European climates and economies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fight Against Large-scale Corruption and Organised Crime Networks' (FALCON), addressing dissemination and exploitation.

assistant: **Impact**

Current evidence suggests that the global fight against corruption faces serious challenges: policy decisions are not well informed, the corruption landscape is complex and enormous, while measuring corruption is so far mostly based on subjective approaches, and there is lack of appropriate technological tools to support anti-corruption. To address these challenges, FALCON is designed and dedicated to support the composition, update and management of comprehensive corruption intelligence pictures, within domains and jurisdictions of interest. This will be accomplished following a multi-actor, evidence-based, data-driven approach, building upon existing assets and prior work of consortium partners. FALCON will, first, develop and validate objective and actionable indicators (individual and composite) of corruption that can be used to inform policy decisions. Second, it will design, implement and integrate powerful data analytics tools, data pipelines and applications that support the management of the entire lifecycle of corruption intelligence pictures. This will enable comprehensive corruption risk assessment, informed policy making, and improved anticorruption law enforcement. FALCON will be piloted in four corruption domains – corruption schemes at border crossings, sanction circumvention by kleptocrats/oligarchs, public procurement fraud, conflicts of interest of politically exposed persons (PEPs) – involving law enforcement experts (police authorities and border guards) from six (6) European countries and other key actors (i.e., GovTech providers, academia, financial intermediaries, policy makers, NGOs, and civil society). FALCON’s implementation will be incremental and iterative, forming synergies between SSH and technological expertise, and will adhere to the pri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography' (NaWaTL) under Horizon 2020.

assistant: **Objectives**

This project deploys an innovative interdisciplinary mixed-methods approach to studying the cultural patterns of ancient Mesoamerican civilization. The study combines traditional comparative analysis of language history with quantitative phylogenetic methods, and with qualitative analyses from epigraphy and ethnohistory to answer a central question in Mesoamerican history: When and from where did the community of linguistic forebears of the Nahuatl-speaking Aztecs disperse in Central Mexico, and are they likely to have played a role in the development and/or downfall of the metropolis of Teotihuacan (ca. 150-600 CE)?


**Keywords:** Mesoamerica, archaeolinguistics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of a Novel Compact Multi Fuel Steam Reforming Device Integrated into a cost effective Fuel Cell Micro Combined Heat & Power Generation System for Residential Building Application'.

assistant: **Innovation**

The construction sector represents a strategically important sector for the European Union employing in 2005 13.8 million people, SMEs are indeed the major force of the construction sector representing 99% of such industry. The EU Building Sector is a major energy consumer (more than 40% of the total energy consumed in the EU is used to cover the needs for heating, cooling and electricity). According to Directive 2006/32/EC in the community there is a need for improved energy end-use efficiency and according to Directive 2002/91/EC on energy performance of buildings need to be certified. In this scenario, our idea is to develop a 30kW micro CHP system able to provide heat and power for a more efficient energy end-use in buildings. The main objective of H2OME is to introduce the novel concept of a Polymeric Electrolyte Membrane (PEM) Fuel Cell based CHP system able to satisfy both the thermal (heating and sanitary water), cooling and electrical power need of the whole building replacing the small methane boiler installed in the single flats as well as old-fashioned centralised oil thermal plant used in the 60s. In order to achieve the above overall objective the following innovations need to be developed: 1)compact and high efficiency steam reformer able to operate with methane, methanol and bio-gas; 2)composite catalyst compound promoting water gas shift reaction with a temperature of about 300°C and able to operate with an hydrogen rich mixture without any CH4 formation; 3)a novel thermal spraying-based manufacturing process for the production of the helicoidally shaped structure made by a metallic mesh coated with a ceramic porous coating catalytic layer. As a consequence of the new directives, it is estimated that 10 million boilers in European homes more than 20 yea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'WHEAT GLUTEN AS BIOPOLYMER FOR THE PRODUCTION OF RENEWABLE AND BIODEGRADABLE MATERIALS' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The increasing demand from consumers and industry for environmentally friendly and renewablepolymers explains the great interest for plant macromolecules as substitutes of synthetic,petroleum-based, polymers. Besides starch and cellulose which have been extensively studied,proteins exhibited great potential for biopackaging materials, plastic fims, adhesives anddisposables (1). The use of proteins as film forming agents concerns various applications :edible films, coatings, soluble films, biodegradable films.In the present project we want to focus on :- films for food packaging : special attention will be paid to biodegradable films with selective permeability for gases like O2 and CO2 or to water and aroma;- plastic films for agricultural use;- coatings for different substrates.The use of wheat gluten as a substitute for synthetic polymers appears as a very interesting optionfor many reasons :1. Wheat is a major crop in Europe, well adapted to the lands and climates, but new valorisation is desirable to insure continuous development of agriculture;2. Gluten is available in large amounts at a reasonable cost;3. The physicochemical properties of wheat gluten make it a raw material particularly interesting for many non food utilisations, especially for making plastic materials. Properties of interest are mechanical, film forming, adhesive, and barrier properties. Protein properties can be well adapted by physical, chemical and enzymatic treatments.Previous studies have shown that it is possible to make transparant and strong films from gluten.Sofar, food applications have been considered, but this project will be more focused on the useof gluten in non-food applications, an unexploited field. In order to reach large scaleapplications, more knowledge is needed on the inter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Long-term economic projections and scenarios' (2002-2006).

assistant: **Innovation**

Specific Objectives:1. To indicate in quantitative terms what the implications of the Lisbon strategy are for each Member State and Candidate Country, taking into account its current employment situation and the potential growth and employment of the main sectors on which its economy depends;2. To ensure that the various policies are consistent with the Union's long- term objectives, and that economic, social and environmental considerations receive equal attention. Anticipated milestones and schedule;1.1 Tables with 28 entries;2.1 Report containing long-term economic projections (at least up to 2010) and chapters on economic growth and sustainable (environmental) development.Planned Deliverables:1.1 Tables with 28 entries 2.1 Report containing long-term economic projections (at least up to 2010) and chapters on economic growth and sustainable (environmental) development.Summary of the Action:The work here is to create an expert system making use of formal methods (econometrics) and systematic tools (economic models) to identify and analyse the regional and global challenges which the present and future EU Member States face in the process of economic integration in the next decade. The work is a direct outcome of the enlargement futures steering group meeting in May 2002, in which there was a significant involvement of User DGs. In 2003 expert groups will launched to support for economic model simulations and scenarios. They will examine the main drivers of change, specific to the economic integration process, and analyse the ways to achieve the EU's targets of competitiveness and sustainability. The action is aimed at informing European policy makers and the public at large about policy challenges related to future technological and socio-economic developments. Ration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pancreatic stellate cells - sentinels for tissue damage?' (2007-2013).

assistant: **Concept**

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease killing about 7000 people in the United Kingdom every year. PDA is resistant to conventional therapy. A hallmark of PDA is the abundance of desmoplastic stroma, which is thought to originate by activation of pancreatic stellate cells (PSC). Unfortunately, little is know about the precise role of PSC in the physiology of the pancreas. In this proposal I will investigate the function of the pancreatic stellate cell in health and during tumour development using a murine model of PDA. I hypothesize, that PSC function as antigen-presenting cells surveying the microenvironment for tissue damage. I postulate, that PSC induce repair processes as well as immunosuppressive responses by means of retinoic acid signalling (PSC are a major vitamin A storage) and the secretion of TGFbeta. This anti-inflammatory program may serve to prevent the autoimmune destruction of the pancreas, an organ indispensable for survival. However, during cancer development this default program may be detrimental as it inhibits the mounting of a proper anti-tumour response.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cartilaginous tissue regeneration by non-viral gene therapy; taking the hurdles towards efficient delivery' (CARTHAGO).

assistant: **Innovation**

Chronic low back pain due to intervertebral disc (IVD) degeneration and osteoarthritis (OA) worldwide impact human health and well-being due to pain and impaired mobility. Non-viral gene therapy has great promise as safe and precision treatment to restore IVD and joint tissue health. However, the lack of accessibility of the affected cartilaginous tissues to drugs has inhibited progress in this field. We will finally fulfil the promise of non-viral gene therapy in these diseases. We will do this through educating 15 young researchers in 10 different countries in physics, quality by design (QbD), nucleic acid chemistry, nanomedicine, cartilage and IVD biology, ethics, entrepreneurship and academic transferable skills. This highly multidisciplinary team will exploit the potential of gene therapy in IVD and joint disease by taking a multi-faceted approach towards the delivery and activity of oligonucleotides and encoding nucleic acids (NA). Cell and tissue delivery will be achieved by nucleic acid modification, innovative nanocarriers and tissue targeting, supported by QbD. Ultrasound will for the first time be used to enhance NA tissue penetration and transfection, and to trigger local release from systemically administered endogenous albumin-NA conjugates. Imaging tools will be developed to monitor in vivo regeneration, saving numerous animal lives in the future. Moreover, we will set up an educational framework for embedding biomedical ethics in biomedical research and valorisation, providing a firm and sustainable basis for Responsible Research and Innovation for future biomedical science and technology. Participation of a patient organisation and a scientific organisation experienced in the dialogue with society, will ensure researchers at ease in communicating with d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'GOAL: Growing Older, stAying mobiLe: The transport needs of an ageing society""' (GOAL).

assistant: **Innovation**

The aim of GOAL is to provide an action plan for innovative solutions to fulfil the transport needs of an ageing society. This action plan will be developed by state-of-the-art reviews, identification of possible and relevant societal developments and alternatives to transport. We identify relevant research gaps and product developments through contacts in the USA and Japan. The focus of GOAL is on land-based transport.Current predictions of EUROSTAT show that “The share of people aged 65 years or over in the total population is projected to increase from 17.1% to 30.0% and the number is projected to rise from 84.6 million in 2008 to 151.5 million in 2060. Similarly, the number of people aged 80 years or over is projected to almost triple from 21.8 million in 2008 to 61.4 million in 2060”. In order to keep them actively involved in society and maintain independence, it is vital that older people, now and in the future, are able to travel and have access to transport.In GOAL we describe the physical and mental characteristics of older people and use these to develop profiles which will represent the range of characteristics to be formed in the population now and in the future. These profiles will be used to explore in a structured way the needs while driving, using public transport, walking and cycling and the relevant information needed before and during travel. The profiles will also be used to address additional issues of older people and other developments which may impact on travel decisions in the future. There is considerable expertise in the consortium related to all aspects of the project. However, to validate our work and to ensure that it will have the widest acceptance, we will be running a series of workshops to enable the widest constituency of stakeholder
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Training of Train Drivers in safety relevant issues with validated and integrated computer-based technology' under Sixth Framework.

assistant: **Concept**

As a continually growing economic area the European railway sector is characterised by increasing advancements in technology and staff requirements. In order to achieve safe, competitive and interoperable railways a particular attention to the qualification of train drivers is essential. To realise a consistent European level of drivers' competencies it is necessary to establish common training technology, common training contents as well as generally accepted assessment procedures. Based on experiences mad e in the past, 2TRAIN aims at developing European standards for the training of train driver competencies providing best-practice guidelines for an efficient, safety enhancing and cost-effective use of latest computer-based training technologies. Starting point of 2TRAIN will be a benchmarking of training technology, contents and models already in use in Europe. To reach a harmonisation of today's diverse training technologies and to allow a standardised driver evaluation, a common data interface will be developed and implemented into three simulator pilots (Spain/France/Germany).In addition, a CBT-pilot will be realised (Czech Republic). In the second step common training simulation scenarios and CBT modules will be developed that will particularly focus o n the training of crisis management competencies and abilities to act in rarely occurring hazardous situations. The trainees' actual behaviour will be compared to predefined target behaviour. The results will be stored in an assessment database that will b e used as a base for the development of a virtual instructor and further add-on systems, e.g. standardised performance evaluation. The quality of 2TRAIN is ensured by a) a close collaboration between operational railway companies (incl. light rail and metro) and