RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MAINSTREAMing small-scale BIO-based solutions across rural Europe via regional Multi-actor Innovation Platforms and tailored innovation support' (MainstreamBIO) under Horizon Europe.

assistant: **Objectives**

The development of the bioeconomy holds great potential for driving growth in a sustainable manner. Still, many European regions have yet to unlock this potential, despite considerable investments in research, innovation and business support. In this context, MainstreamBIO sets out to get small-scale bio-based solutions into mainstream practice across rural Europe, providing a broader range of rural actors with the opportunity to engage in and speed up the development of the bioeconomy. We start with regional Multi-actor Innovation Platforms (MIPs) established in 7 EU countries (PL, DK, SE, BG, ES, IE and NL) to enhance cooperation among key rural players towards co-creating sustainable business model pathways in line with regional potentials and policy initiatives. Alongside them we support 35 multi-actor partnerships to overcome barriers and get bio-based innovations to market with hands-on innovation support, accelerating the development of over 70 marketable bio-based products and services. In parallel, we develop and employ a digital toolkit to better match bio-based technologies, social innovations and good nutrient recycling practices with available biomass and market trends as well as to enhance understanding of the bioeconomy with a suite of educational resources building on existing research results and tools. Along the way, a monitoring and evaluation framework will gauge the performance and impact of our measures, providing us with the intel required to catalyse mutual learning across regions and contribute to the creation of policy frameworks more conducive to the uptake of small-scale bio-based solutions in rural areas. In the process, we cluster with relevant initiatives and offer tools to facilitate the replication of our results, ensuring their long-ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'CivDrone – fast, remote and reliable staking solution' under Horizon 2020.

assistant: **Concept**

Every construction work follows precise blueprints and instructions. When the project plan is implemented in the real-worldsite, the land surveyor places physical markers, also known as stakes, according to the general contractor’s constructionplan. The staked reference points include instructions of the works that needs to be done – for instance how deep to dig inorder to place the pipeline in the right depth. Most construction tasks require physical staking, even simple tasks such asplacing the road railing and sidewalk. Physical staking is a laborious and time-consuming job that presents multipledrawbacks such as slow measurement and staking process and manual marking mistakes, leading to higher upfront anddownstream costs. CivDrone’s innovative staking mechanism is installed on an enterprise drone equipped with RTK system.The drone flies autonomously to the desired coordinates and inserts the stakes in the ground. Tags contain all relevantinformation for the work of the general contractors, so the constructors will be able to get all the tasks and updated blueprintsdirectly on their own smartphone/tablet when moving in the working field. During the phase 1 project, a go-to-market strategyand a supply chain will be established, as well as further development plan will be drafted. The Phase 2 innovation projectwill allow for engineering and development of the navigation system and staking mechanism to achieve higher accuracy andfunctionality, scale up of production to produce mechanism and stakes for pilot trials with potential construction, train, road,and pipeline companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Gene therapy of hematopoietic stem cells for inherited diseases' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

INHERINET aims to develop novel, safe and curative treatments based on therapeutic gene transfer into antilogous (i.e., patient-derived) haematopoietic stem cells for selected example hereditary diseases, which include immunodeficiency's, mucopolysaccharidosis VI, Diamond-Blackman anaemia and Gautier's disease. It entails:1. State-of-the-art vector development and production.2. Polyclinic engraftment of gene-modified cells in preclinical animal models and tolerance for transgenic products.3. Selection of gene-modified cells.4. Disease specific animal model s to evaluate safety and efficacy. The project is intended to conclude with the preparation of clinical protocols to file for clinical trials based on the achievements, enabling discussion with expert panels on social and ethical aspects of the proposed therapeutic intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'CHARACTERIZATION OF FUNCTIONAL METABOTROPIC GLUTAMATE RECEPTORS IN GLIAL CELLS'.

assistant: **Objectives**

Research objectives and content Metabotropic glutamate receptors (mGluR1-8) are a family of receptor subtypes with diverse properties in terms of transduction coupling, pharmacology, anatomical and cellular expression. In cultured glial cells activation by t-ACPD leads either to intracellular IP3 accumulation with subsequent mobilization of calcium from internal stores or to reduced cAMP formation. In situ, in living brain slices, only few physiological or biochemical investigations to uncover the function of glial mGluRs have been performed. A combination of several techniques will be applied to investigate the functional expression of the so far known metabotropic glutamate receptors in individual glial cells of the mouse brain. During electrophysiological characterization using patch-clamp or imaging techniques, the expression of mGluR subtype transcripts will be determined by single-cell RT-PCR allowing a direct correlation of physiological behaviour and receptor molecule being involved. Histological techniques will be used to confirm the expression. Training content (objective, benefit and expected impact) The hosting research group has setup electrophysiological, imaging and molecular biology techniques to study the role of glial cells in the brain. They offer a unique opportunity to study the physiology of many different glial cell types simultanously by patch-clamp recording, confocal microscopy, [Ca2]i imaging, and single-cell RT-PCR. In particular, all the techniques can be applied to the more intact environment of the living brain slice. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OPEVA - OPtimization of Electric Vehicle Autonomy' to be submitted under Horizon Europe.

assistant: **Abstract**

The project OPEVA aims for innovation on aggregating information from the vehicle, not only from the battery but also from other internal sensors and behaviours, to create a model of performance and consumption specific to the individual vehicle and its driver (TD1). It aims to optimize the individual driving episode using the out-vehicle data such as state of the road, weather, charging station location and occupancy etc. that are collated from the back-end systems (TD2).  OPEVA will further address the challenges associated with the communication between the vehicle and the infrastructure to gather data from the back-end systems (TD3). It aims for innovation in the use of recharging stations and related applications (TD4). It further aims to achieve better understanding on what the battery and its constituent cells are really doing during real world use for an improved battery management system (TD5). Finally, TD6 covers the driver-oriented human factors for optimizing the electrical vehicle usage. The TDs from the most deeply embedded in the vehicle to its support in the cloud, which need to interwork in an optimal fashion to deliver in one decade a better level of systemic optimisation for personal mobility that took ten decades to achieve with fossil fuels. On the other hand, economic factors (N-TD1), legal and ethical aspects (N-TD2), EV related development by the human (N-TD3), and societal and environmental factors (N-TD4) will be taken into consideration in the OPEVA methods for a higher acceptance and the awareness of the society regarding the these developments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'European Standardisation of outcome measurement in rehabilitation'.

assistant: **Innovation**

Objectives:- To identify the outcome measures used in rehabilitation across Europe. - To evaluate both the cross-diagnostic and cross-cultural validity of a selection of outcome measures. - To co-calibrate different measures assessing the same construct (within country and diagnosis). - To construct an item bank for each outcome construct used in rehabilitation.Brief Description:Rehabilitation has a major role to play in ameliorating the consequences of disease. However, the increasing need to compare health status within and across diagnostic groups at the regional, national and international level is compromised by the diversity of outcome measures. Such problems are exacerbated throughout Europe, where several languages are spoken.$L New methodological approaches based on the work of Georg Rasch have the potential to identify outcome measures that work consistently across different diagnostic groups and countries. These highly innovative and powerful techniques will be used to address the problem of standardisation of outcome measurement in rehabilitation. A postal questionnaire will identify the outcome measures currently in use throughout rehabilitation in Europe. A set of measures will be selected for inclusion in the project based on clearly defined criteria that will be determined at a review meeting following the survey. These criteria are likely to include the extent of use of any measure and their relevance to important diagnostic groups, such as stroke and arthritis. Anonymous copies of data from the selected instruments will be obtained from members of the network. These data are currently collected as part of routine clinical practice, or in research projects for purposes of methodological evaluation. Some members of the network will, however, introduce ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanobiotechnology: Responsible Action on Issues in Society and Ethics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The overall aim of this Co-ordination Action is both, firstly, to anticipate the societal and ethical issues likely to arise as nanobiotechnologies develop and, secondly, to use the lessons from the European GM debate to respond pro-actively and responsib ly to the probable public, media and political concerns. This is an interdisciplinary ethics research and communication project with the objectives to: - bring together the key relevant players in the field including committed ethicists, social scientist s,  nanobiotechnologists, communication specialists, SMEs and major companies using nanobiotechnology, - horizon-scan for the scientific and commercial developments likely to cause public and political concern - clarify the ethical issues involved or as they arise, and recommend and carry out strategies for public communication to address the emerging questions - take on board the experiences and lessons learned from the European GM debate of the last decade and apply them  with this project to the na nobiotechnology discussions - incorporate the recommendations of the European Commission's Communication Towards a European Strategy for  Nanotechnology" and the results of its current Nanoforum public consultation which surveys European public opinion  on these issues - prepare for the relevant actions in the European Commission's Action Plan for Nanotechnology to be published in 2005 and the Technology Platform on Nanotechnology foreseen in its Seventh Framework Programme commencing in 2007 The p roject will implement these objectives by means of: - an expert group, on-line forum & bibliographic database - horizon scanning workshops - public opinion focus group discussions - ethics & public communication courses for nanobiotechnologists - briefing papers for specific au
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SEEDS OF BRAVERY: supporting Ukraine’s tech start-up scene and bringing it closer to the EU'.

assistant: **Innovation**

Based on a detailed analysis of the situation of UA Innovation Ecosystem after Russian invasion, partners (7 Ukrainian partners and 11 partners from 11 other EU member States with an extensive outreach capacity spanning across key EU and global markets) have put together a proposal aimed at providing support to counteract the harm done to Ukrainian startups and deep tech SMEs in the short term, building a framework that supports the Ukrainian Government’s goal of becoming a ‘start-up nation’, and increasing the role of innovators and the deep tech industry in driving growth. This will be achieved through a comprehensive portfolio of support services that combine cascade funding (10k-25k-50k grants), access to finance actions (connecting to public funds and private investors, training on EIC, EIT and other cascading opportunities etc.), deep-tech-focused incubation and acceleration programmes, and market access initiatives (targeting 10+ countries, soft landing in 10 key sectors/verticals, and working spaces in 50+ locations across Europe). Pan-European integration – which brings UA innovation closer to investors, accelerators, potential buyers, innovation agencies and peers - will also be a key component of this project. The Consortium is led by FBA (PL-based and leader of FSTP management) with key support from USF, Ukraine’s public agency to support SMEs, which will invest its own resources and guarantee synergies with UA. Other partners key to guarantee services delivery and wide impact are: EITH (KICs), PNP (investors), LXI (EU innovation stakeholders), CORKBIC (BIC network), IHS (Impact Hub Network), IOP (EEN in UA). Circa 1,000 innovators, start-ups and deep tech SMEs located in UA or created by Ukrainian citizens in other EU countries after 24.02.2022 will benefit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single-enhancer knockout analysis of Myf5 function in the developing mouse embryo' (EPAXIALMYF5KO).

assistant: **Concept**

During embryonic development the integration of numerous synergistic signalling pathways turns a single cell into a multicellular organism with specialized cell types and highly structured, organized tissues. To achieve this, cells must grow, proliferate, differentiate and die according to their spatiotemporal position. Unravelling the mechanisms by which a cell adopts the correct fate in response to its local environment remains one of the fundamental goals of biological research. In vertebrates skeletal myogenesis is orchestrated by the activation of the myogenic regulatory factors (MRFs) in response to signals that are interpreted by their associated regulatory elements in different precursor cells during development. The MRFs trigger a cascade of transcription factors and downstream structural genes, ultimately resulting in the generation of one of the fundamental histotypes.Myf5, the first of these MRFs to be activated in the mouse embryo, is first expressed in the dorsomedial lip of the dermomyotome. In the absence of Myf5, the myogenic process is delayed for 48h. The phenotype is rescued by the activation of another member of the MRF family, MyoD. In the double Myf5/MyoD KO animals there is no rescue of the phenotype and they lack all skeletal musculature.To further investigate the function of Myf5, we have generated a new inducible KO strain in which the enhancer element that drives the first wave of Myf5 expression in the dermomyotomal lip can be deleted from the genome. Preliminary data show that this domain of expression has been specifically targeted.We plan to fully characterise the new KO strain and to study the effects of eliminating Myf5 function only from the dorsomedial lip. Furthermore, we will cross it with the MyoD KO strain in order to block myogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a non chromated, Reach’s compliant anodic electropaint, with very low volatile organic compounds, for high protection against electrochemical corrosion of pickled aluminium alloys used' (2007-2013).

assistant: **Concept**

The current way of protecting aluminum alloys used for structural components of aircrafts consists in:ousing a surface anodizing pretreatment (hazardous chromated pretreatment still often used)othen spraying either a chromated solventborne paint or a chromated waterbased paint. With this process of application, hazardous oversprays (containing chromates) are important and only 40% in average of the paint is transfered to the surface.•PPG is the historical leader in electrodeposited paints. We have all the expertize and equipments available in that field to design new polymers, formulate anaphoretic paints,  characterize surface and interphases, design ecoat lines, educate and assist users.•PPG is also leading the Aerospace market segment for paints and sealants. We have built a strong experience in chromate free primers for corrosion protection of structural components of aircrafts.•Based on our experience the use of anodic paint is ustified for Aerospace aluminium alloys because :•a protective anodic layer is formed at the same time the paint deposits at the surface of the alloy during the electrophoresis process. That will allow to eliminate the current hazardous anodizing process step•as aluminium alloys used in Aerospace cannot support temperature above 120°C, anodic paint technology only is adapted•VOC is bellow 100g/l•Transfer efficiency is very high (98% vs 40% for current paints used for same purpose) so almost no wasteFirst screening done by using an existing PPG anodic paint showed encouraging results vs Aerospace main OEMs specifications. In particular critical tests like hydraulic fluid resistance and water resistance were achieved Al2024 alloy without anodizing pretreatment. Also first corrosion tests performed on Al2024 were closed to the target (3mm max f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Laser Dismantling Environmental and Safety Assessment' (LD-SAFE) under Horizon 2020.

assistant: **Objectives**

The aim of NFRP-2019-2020-09 call is to capitalise existing technologies for characterisation and risk assessment, dismantling, on-site waste management and environmental remediation in order to gain needed efficiencies in the decommissioning of nuclear power reactors.One very challenging dismantling task in the focus of the industry is the segmentation of the reactor pressure vessel and internals. Limitations are known for all conventional cutting techniques currently used including mechanical cutting, plasma arc cutting or abrasive water jet cutting.In this context, the laser cutting technology for nuclear dismantling, an adaptation from the manufacturing industry developed by over a decade of R&D efforts, is identified in Europe and elsewhere in the world as a promising alternative.The objective of the LD-SAFE project is to validate the laser cutting technology for the dismantling of the most challenging components of power nuclear reactors in air and underwater.LD-SAFE project will remove the last barriers to enable the replacement of conventional cutting techniques and prove by 4 specific objectives that the technology is mature (TRL7):-Objectives 1: Demonstration of the capabilities of a versatile laser cutting solution to address the key technical challenges in decommissioning of large nuclear facilities-Objectives 2: Environmental and safety assessment of the implementation of laser cutting for nuclear reactor decommissioning-Objectives 3: Technical validation of the laser cutting prototype in operational environment (TRL7)-Objectives 4: Demonstration of the economic advantage of using the laser cutting technology for the forthcoming reactor decommissioning marketLD-SAFE consortium is a strong partnership of 4 leading industrials and 2 European research centres