RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards new Rail freight quality and concepts in the European Network in respect to market Demand', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The Commission's White Paper clearly demonstrated why the international rail freight services have lost in competitiveness and market share compared to road. The White Paper, too, designed a general framework of actions which, if applied by the relevant parties, would strengthen this sector and contribute to advance an innovative network of competitive integrated Pan-European services.Against this background, the TREND proposal sees its responsibilities in providing two major results as an input to the EC rail transport policy, thus responding to the Call 2A requirements: First of all, TREND gathers all necessary information to assess the general progress in the establishment of an European Railway Area. As a core product this Part A will provide an improved Integration Index" which is composed of a set of sub-indices covering amongst others the issues of liberalization, free access, interoperability etc."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inhibitors of ECF transporters as novel antibacterial agents' (InECFAb) under Horizon Europe.

assistant: **Objectives**

Antimicrobial resistance is a global health threat, urgently calling for the development of novel anti-infective strategies. We will adopt a multidisciplinary approach to design, synthesize and optimize derivatives targeting ECF transporters as antibacterial agents. The ECF transporters are transmembrane proteins involved in the uptake of vitamins predominantly in Gram-positive pathogens (e.g., Streptococcus pneumoniae, Enterococcus faecalis, E. faecium, Staphylococcus aureus). Their inhibition prevents the uptake of vitamins from the environment, leading to starvation followed by cell death. Due to their critical role in the homeostasis of vitamins in bacteria as well as their absence in humans, ECF transporters are considered a promising novel antimicrobial target.  We will thoroughly profile our  inhibitors for their in vitro on-target and antibacterial activities. We will, on the one hand, further validate the cellular target through advanced target engagement studies and attempt to achieve a co-crystal structure using cryo-electron microscopy. Furthermore, evaluation of the inhibitors for their in vitro ADME-T properties and in vivo pharmacokinetic profiles will set the stage for in vivo infection models in mice. The extensive data that we will gather will enable us to nominate the most promising compound(s) for further multiparameter optimization en route to the nomination of a preclinical candidate. Ultimately, this opens access to novel anti-infectives with an unprecedented mode of action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Larvi 2001: 3th fish and shellfish larviculture symposium' to be submitted under Fifth Framework.

assistant: **Abstract**

Larviculture has frequently proved to be the bottleneck in aquaculture practices due to the fragility and lack of understanding of the early life stages. Therefore research in larviculture of fish, shrimp and bivalves has always been quintessential for any progress in aquaculture activities.A first symposium was organised at the Ghent University in 1991 (Larvi '91). It was attended by more than 250 researchers, professionals and students. In 1995 Larvi '95 was organised and attended by over 300 participants, many of them for the second time. It is clear that a conference with a strict focus on larviculture but covering the wide area of relevant disciplines fulfils the effective need for an update on recent developments and an exchange of views.The objectives of the project Larvi 2001 symposium are: 1/ Present the state-of-the-art of current larviculture practices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synthetic Chimeric Antigen Receptors: Hijacking Nitrenium Ions for Targeting, Therapy and Safety of Next Generation T Cell Therapy' (SynCAR-Ts) under Horizon Europe.

assistant: **Objectives**

Chimeric antigen receptor (CAR) T cell therapy is a promising approach for cancer treatment with remarkable clinical outcomes. CAR T therapy involves the isolation of patients T cells that are genetically modified with an engineered antigen receptor to attack cancer cells.Despite the great promise, the rapid activation and proliferation of CAR T cells can lead to serious side effects. In addition, CAR T therapy is challenged by limited effectiveness, difficulties in infiltrating solid tumors, targeting of healthy cells, cell exhaustion and an expensive, lengthy and personalized manufacturing process. Over the past years, researchers have explored many strategies to improve and control CAR T cell function and to develop more universal CAR T cell platforms. Yet, an off-the-shelf approach that allows full control of CAR T effector function, that is flexible in use and can be obtained at low manufacturing costs, is currently not available.To address above challenges, I will develop a highly innovative, universal synthetic CAR (SynCAR) T cell platform where the antigen receptor is easily adaptable by using synthetic, functionalized targeting ligands to control T cell effector function in space and time.At the basis of this proposal lies the use of highly reactive and activatable aryl nitrenium ions for protein modification, drug delivery and as novel class of therapeutics. I will 1) tune nitrenium ion reactivity for bioconjugation and drug activation 2) use enzyme-activatable nitrenium ion precursors for synthetically modified antigen receptors, 3) develop novel nitrenium ion-based prodrug strategies to improve CAR T efficiency and 4) use innovative bioorthogonal chemistry to control CAR T activity in time and space.In this work, I will develop beyond the state-of-the-art ch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Understanding the atmospheric circulation response to climate change'.

assistant: **Innovation**

Computer models based on known physical laws are our primary tool for predicting climate change. Yet the state-of-the-art models exhibit a disturbingly wide range of predictions of future climate change, especially when examined at the regional scale, which has not decreased as the models have become more comprehensive. The reasons for this are not understood. This represents a basic challenge to our fundamental understanding of climate.The divergence of model projections is presumably related to systematic model errors in the large-scale fluxes of heat, moisture and momentum that control regional aspects of climate. That these errors stubbornly persist in spite of increases in the spatial resolution of the models suggests that they are associated with errors in the representation of unresolved processes, whose effects must be parameterised.Most attention in climate science has hitherto focused on the thermodynamic aspects of climate. Dynamical aspects, which involve the atmospheric circulation, have received much less attention. However regional climate, including persistent climate regimes and extremes, is strongly controlled by atmospheric circulation patterns, which exhibit chaotic variability and whose representation in climate models depends sensitively on parameterised processes. Moreover the dynamical aspects of model projections are much less robust than the thermodynamic ones. There are good reasons to believe that model bias, the divergence of model projections, and chaotic variability are somehow related, although the relationships are not well understood. This calls for studying them together.My proposed research will focus on this problem, addressing these three aspects of the atmospheric circulation response to climate change in parallel: (i) diagnosing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eurosoundflow' under Fifth Framework.

assistant: **Concept**

The school scientific content, sound and flow interactions, covers many of fundamental and applied research. The coupling between acoustic waves and flow motion is basically non linear. The sound propagation and generation is modified by the flow and the flow can also be modified by the sound. As a result, this problem is investigated in many different scientific communities, such as applied mathematics (resolution of non linear, coupled, partial differential equations), hydrodynamics (instabilities governed by an acoustical source), acoustics (sound propagation and scattering by complex flows, boundary layer control), low-temperature physics (superfluid measurements using second sound interactions), mechanical engineering (transducer development and signal processing techniques), environmental sciences (sound generation, characterisation of multiphase flow e.g. fogs) and medical sciences (blood flow).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Detoxification of waters for their recycling and potabilisation by solar photocatalysis in semi-arid countries' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This proposal is addressed to the development and on site assessment of a fully autonomous solar reactor system to drinking water purification in semi-arid areas of the mediterranean basin. The scientific and technological required developments will be based on photocatalytic generation of hydroxyl radicals and singlet oxygen species, by using sunlight, to detoxify and disinfect contaminated (at trace level) drinking water respectively. Detoxification system will use Toil supported catalyst and disinfections system will be generated by supported sensitises photo activated by solar light. Final development system is expected to have remarkable technical features as well as social, development and environmental implications in mediterranean countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A novel role for skeletal muscle in tumour growth and proliferation'.

assistant: **Concept**

Cachexia is a life-threatening condition characterized by a drastic loss in both muscle and adipose tissue, which is associated with several pathologies, including cancer. In cancer patients, its prevalence is of 50-80%, and is the direct cause of at least 20% of cancer-associated deaths. Cachectic patients show lower response rates to chemotherapy and a reduced tolerance to anticancer treatment, being of major clinical relevance. So, while cachexia is clearly of great significance for disease prognosis and survival in general, it is mainly considered a consequence of the presence of the tumour. Tumour-induced muscle wasting is due to the development of “anabolic resistance,” which is the impaired ability of nutrition and exercise to stimulate muscle protein synthesis. There have been results, however, which suggest that prevention or reverting muscle mass can lead to significant improvements of survival and overall well-being of tumour-bearing animals. While these results are suggestive of an important role for skeletal muscle, whether or not this is due to a direct effect on tumour biology is not well-established. The proposed project is based on preliminary results showing that tumour growth and proliferation are affected by activating the anabolic kinase Akt specifically in skeletal muscle in vivo, suggestive of muscle-tumour crosstalk. Follow up experiments performed using a microfluidics system showed that this effect is likely mediated by factors directly released by skeletal muscles, and not through indirect effects, like altering food intake or modulation of the immune system. In the current project, we propose to confirm and further decipher the muscle-tumour crosstalk in vivo. Subsequently, we propose to identify muscle-secreted factors with a microfluidics a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Association of European Marine Biological Laboratories Expanded' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Marine biological stations have offered services and biological resources to science for more than a century. ASSEMBLE Plus will provide scientists from academia, industry and policy with a quality-assured programme of Transnational Access (TA) and Virtual Access (VA) to marine biological stations offering a wide variety of marine ecosystems, unique marine biological resources, state-of-the-art experimental and analytical facilities with integrated workflows, historical observation data, and advanced training opportunities. The goal is to stimulate European excellence in fundamental and applied research in marine biology and ecology, thereby improving our knowledge- and technology-base for the blue economy, policy and education. ASSEMBLE Plus brings together 33 marine stations and institutes with modern research infrastructure and track-records of unique service provision from 14 European and associated countries under the leadership of the European Marine Biological Resource Centre (EMBRC), an ESFRI consortium developed from the previous ASSEMBLE (FP7) partnership. Joint Research Activities involving all partners aim to develop innovative new technologies and/or methodologies to be offered to users through the TA and VA programmes. A coherent series of Networking Activities (NAs) will strengthen the culture of cooperation within and beyond the consortium, providing benchmarks for refined practices of service provision, disseminating interoperable protocols, engaging with novel user communities, and sharing insights into business strategies. The sum of the actions envisaged in ASSEMBLE Plus will ultimately increase the number of users of marine biological stations and shape novel strategic development perspectives, to be based on effective integration and efficient comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Lightweight, Energy-Efficient Tooling for the Manufacturing of Rotor Blades' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This proposal argues that the main objectives of the undertaking, light-weight and energy-efficient tools, can be achieved by the creation of self-heating composite tools which are appli-cable in an RTM process. The aim is to establish a set of full-sized rotor blade tools for a low-cost and energy efficient RTM cycle. This contains two tools (upper and lower mold) for preforming, consecutively referred to as “preforming tool” and two molds that form the impregnation and curing cavity, consecutively referred to as “RTM tool”.Considering the RTM tool, the self-heating property is to be achieved with heating elements that are integrated into the composite structure near the cavity surface. The carbon textile heat-ing elements are flexibly distributed in reference to the mould surface in such a manner, that temperature gradients over the entire tool can be created.During the project alternative systems which offer the equivalent potentials for heating like electrically heat able coatings will be considered and evaluated. Enhanced local heating device capable of high and homogeneous temperature for tool manufacturing will be investigated.Integration and enhancement of process simulation tools in the design process for the RTM tool will provide feedback on setup variants in terms of temperature and material property distri-bution like glass transition temperature and degree of cure, as well as the resulting part’s shape “as built”, and thereby will help to establish a RTM tool design including the advanced heating concept “first right”. Curing simulation is the tool of choice to analyse the thermal response of the tool part setup including the energy release due to the crosslinking reaction of the resin and is vital for virtual process and tool optimization.To verify the ach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bioethical implications of globalisation processes' (BIG), addressing dissemination and exploitation.

assistant: **Impact**

BIOETHICAL IMPLICATIONS OF GLOBALISATION PROCESSES (Acronym: BIG) is a provisional project that aims to anticipate the major reasons for bioethical concern surrounding globalisation, to forecast future scenarios and to formulate new policy options in this field. The project' s purpose is both to raise short-term, tactical considerations and to provide a longer-term, strategic perspective. The project will achieve its aim by convening expert meetings and developing a number of rounds of Delphi questionnaires. A high-level seminar involving a selected audience of EU policy-makers will conclude the study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Highly Energy-Efficient Resistive Switching in Defect- and Strain- Engineered Mott Insulators for Neuromorphic Computing Applications'.

assistant: **Objectives**

The pressing need for beyond-von-Neumann computing paradigms has triggered intensive efforts into understanding and controlling various resistive switching (RS) mechanisms. This switching, in which the two terminal resistance of a device is controlled by current is at the heart of emerging technologies such as resistive random access memory and neuromorphic computation. These technologies promise to revolutionize artificial neural networks and mimic the behavior of biological brains, triggering a race the for optimal RS materials.In Mott insulators electrical currents can change resistance by orders-of-magnitude due to an insulator-metal phase transition. The volatility of switching in Mott insulators can be adjusted by several tuning parameters, enabling both memory devices and neuron-like functionalities. Moreover, in terms of fundamental switching timescales and energy efficiency, Mott insulators may have very significant advantages over other RS mechanisms. These unique properties have made Mott insulators prominent candidate materials for RS. However, the physical mechanisms behind RS in these materials are not well understood and often uncontrollable, hampering realization of their full potential. We suggest two main routes towards Mott-insulator-based RS with ultrahigh energy efficiency. The first is by switching purely in the electronic sector while minimizing structural distortions. Thus, the low heat capacity of electrons may enable switching with a fraction of the energy required in an insulator-metal transition coupled to a structural transition. The second is absorption of latent heat and/or elastic energy from the surroundings of the switching volume, thus reducing the externally supplied power consumption. Our aim is to use defects, doping and strain engi