RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Humans - the analogy-making species', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The ability to make analogies lies at the heart of human cognition and is a fundamental mechanism that enables humans to engage in complex mental processes such as thinking, categorization, and learning, and, in general, understanding the world and acting effectively on it based on her/his past experience. This project focuses on understanding these uniquely human mechanisms of analogy-making, and exploring their evolution and development. A highly experienced, interdisciplinary, and international team will study and compare the performance of primates, infants, young children, healthy adults, as well as children and adults with abnormal brain functioning. An interdisciplinary methodology will be used to pursue this goal, one that includes computational modeling, psychological experimentation, comparative studies, developmental studies, and brain imaging.The ability to see a novel experience, object, situation or action as being the same as an old one, and then to act in an approximately appropriate manner (and then fine-tuned to fit the novel experience), is, almost unquestionably, one of the capacities that sets humans apart from all other animals. What are the underlying mechanisms that allow us to do this? How did they evolve in the population? How do they develop in an individual? How do they differ from similar mechanisms in primates? The results from this project will contribute to a better understanding of the mechanisms of analogy-making, their origin, evolution and development and will lead to advances, not only in our basic knowledge of human cognition, but also in the development of educational strategies to help children and young people to be more efficient learners and to achieve a better and deeper understanding of the world in which they live.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project ''vaccines for diseases prevalent in the developing world'' (VACCINATION), addressing dissemination and exploitation.

assistant: **Impact**

GlaxoSmithKline is a research-based company whose people are committed to fighting disease by bringing innovative medicines and vaccines to patients throughout the world and to healthcare providers who serve them. Employing over 100,000 people worldwide GSK has an annual Research and Development budget of £2.4 billion and has major Research sites in the US and Europe. One of the major UK sites is at Stevenage which is the home for the Immuno-therapeutics Department within the Discovery Research Division. Within this Department there are three vacancies for EU fellows working in the area of DNA vaccination against diseases which are prevalent in the developing world including HIV and TB. The programme will provide opportunities for training in a variety of disciplines including molecular biology, cellular immunology and in vivo biology. The GSK Medicines Research Centre at Stevenage is a modern research facility that provides an excellent environment for research training. EU fellows will be fully integrated into ongoing programmes. The focus of the fellows projects will be the investigation of strategies:- a. to overcome immune deviation in chronic disease by vaccinationb. to develop cross-reactive vaccines for highly variable pathogensThe fellowships are for two years and whilst at GW the fellows will be eligible to attend a range of training courses that will complement their scientific training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling oncogenic defects in feedback control of receptor tyrosine kinases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cellular growth and migration depend on intracellular communication webs mediated by polypeptide growth factors. One example comprises EGF-like growth factors and their ErbB receptor tyrosine kinases. EGFR and HER2 are frequently involved in cancer progression, and they serve as targets for cancer therapeutics. The existence of a kinase-dead receptor, as well as the emergence of resistance in patients treated with EGFR and HER2 blockers, instigated a paradigm shift from a linear EGF-to-ErbB cascade to a robust network characterized by multiple feedback loops.We assume that deregulation of feedback loops plays essential roles in human cancer. Because of the abundance of feedback regulation, we predict subtle, multi-component impact on disease.Aiming at the natural richness of feedback regulation in breast cancer, we will develop in vitro models of normal mammary cells, and introduce genetic, disease-mimicry manipulations. Two time domains of feedback regulation will be addressed: (i) the early domain of post-translational modifications, which we will explore using proteomic approaches. And (ii) the late domain comprising alterations in transcription, micro-RNAs and alternative splicing, processes we will investigate using deep sequencing and array technologies. Once verified and characterized in normal cells, we will survey the operational status of the unravelled feedback loops in genetically manipulated cell systems and in tumour specimens, using immunological and bio-informatical approaches.Detailed knowledge of feedback regulation of multi-layered signalling networks, such as ErbB, is expected to shed light on the currently elusive basis of signal integration and elimination of noise, as well as identify markers of prognosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Migrant Domestic Workers in European Care Regimes'.

assistant: **Innovation**

This research project explores parental strategies to reconcile new demands in work and care in conjunction with the increasing European demand for migrant domestic workers in three contrasting care regimes: the U.K., Sweden and Spain. Highlighting the shifting division of labour in the global political economy of care, the project investigates the ways migrant domestic care workers and their European employers negotiate such shifts. In particular, the study focuses on the ways cultural preferences and moral rationalities around child care interplay with gendered and radicalised power relations. Taking into account the agency of individuals constituting the so called global care chain" of female employers and employees, the project also locates men's previously neglected relations to care - as parents and as partners of employers. Furthermore, the study adds a qualitative dimension to cross-disciplinary discussions around welfare state restructuring, feminisation of migration and privatisation of care. By means of semi-structured interviews, the project explores the everyday conditions and strategies of asymmetrically positioned agents in different national contexts. Thus, the project illuminates the ways in which cross-national social, political and economic processes are negotiated in contrasting local settings. For instance, the project investigates the co modification of care by comparing employers and employees' moral distinctions between care for love and care for money and their own boundaries for doable "dirty work" and sellable intimacy. By investigating such localised negotiations and conceptualised meanings of global shifts, the study adds new theoretical and empirical variables to the study of care regimes, migration and the global division of care work. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OPTIMAL REGULATION AND INFRASTRUCTURE FOR GROUND, AIR AND MARITIME INTERFACES' (ORIGAMI).

assistant: **Innovation**

This proposal recognises that effective solutions to existing problems in long-distance door-to-door passenger transport chains require the provision of attractive integrated networks and services and this is likely to require vision and co-operation between stakeholders in the public and private sectors.  ORIGAMI will build on the substantial body of knowledge on long-distance passenger transport already available from past and current projects (in particular KITE, LINK, INTERCONNECT, HERMES and CLOSER) by collecting a substantial body of new data on the attitudes of long-distance travellers to alternative future transport supplies and by collating examples of best practise and of new, yet untried, technical solutions.  One strand of work will then analyse the technical solutions, investigate the extent to which solutions found in one mode can be transferred to other modes, identify barriers to be overcome, and discuss the findings with stakeholders. Another strand of work will investigate traveller behaviour and attitudes in different countries and regions in order to identify the factors, demographics and traveller requirements which are likely to influence future trends in travel behaviour.  Scenarios will be developed to investigate alternative futures and pathways towards a successful intermodal transport system and a range of modelling approaches will be used to forecast the demand for different modal combinations in the different scenarios.  Solutions will be evaluated against relevant criteria for European transport policy and recommendations will be made and disseminated amongst policy makers and other stakeholders including industry representatives and researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Self adaptive heterogeneous manycore based on Flexible Tiles'.

assistant: **Innovation**

A major challenge in computing is to leverage multi-core technologies to enable the development of energy-efficient high performance systems. This is especially critical for embedded systems which have very limited energy budget as well as for supercomputers in respect to sustainability. But, efficient programming of multi-core architectures, moving towards manycores with more than a thousand cores predicted by 2020, remains an unresolved issue. The FlexTiles project will define and develop an energy-efficient and programmable heterogeneous manycore platform (THALES, CSEM, CEA) with self-adaptive capabilities, based on the following innovations:\tEnergy-efficiency, performance and flexibility provided by a reconfigurable layer linked to the manycore and enabling the dynamic instantiation of dedicated accelerators (UR1).\tPower consumption, load balancing, dynamic mapping and resilience to faulty modules managed through self-adaptation features (KIT).\tVirtualised executable codes enabling dynamic relocation of configuration (TUE) and bitstreams respectively on standard processor and network on chip and on reconfigurable layer (UR1).\tA virtualisation layer monitoring the system and optimising the application mapping for load balancing, power consumption and faults tolerance (KIT, TUE).\tParallelisation and compilation tools improvement to take into account the mixture of static and dynamic behaviours (ACE, THALES).FlexTiles proposed final platform will be validated on two main applications (smart camera, cognitive radio) of the targeted embedded technology market (THALES, SUNDANCE). FlexTiles achieved new type of manycore will also benefit from other markets and applications' domains opportunities (e.g. automotive, autonomous systems, medical imaging systems, super
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ion channels in erythrocytes: A novel understanding from regulation of erythropoiesis and physiological function to diagnostic measures and therapeutic concepts' (INNOVATION) targeting Horizon Europe.

assistant: **Abstract**

Erythrocytes represent an estimated 84% of all cells in the human body. During circulation, they experience a huge variety of physical and chemical stimulations, such as pressure, shear stress, hormones or osmolarity changes. These signals are translated into cellular responses through ion channels that modulate erythrocyte function. Ion channels in erythrocytes have only recently been recognised as the utmost important players in physiology and pathophysiology. Despite this awareness, their signalling, interactions and concerted regulation, such as the generation and effects of 'pseudo action potentials', remain elusive. INNOVATION proposes a systematic, conjoined approach using molecular biology, in vitro erythropoiesis, state-of-the-art electrophysiological techniques, methods to detect erythrocyte functionality and patient samples (channelopathies and other red blood cell-related diseases) to decipher and make use of ion channel functions in terms of disease treatment concepts. We need to overcome the challenges that hinder the gain of knowledge within the field, using genetic manipulation of progenitors, cell differentiation into erythrocytes, statistically efficient electrophysiological recordings of ion channel activity that are limited by the heterogeneity of the cell population (120 days of lifespan without any protein renewal) or access to large cohorts of patients.Our multidisciplinary team includes biophysicists and cell biologists to investigate erythrocyte characteristics and bioengineers to develop diagnostic devices. INNOVATION involves academic research centres as well as diagnostic labs providing patient samples, blood bank research centres developing cultured transfusion products and SMEs that provide and develop diagnostic tools or innovative therape
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Tau, a molecular modulator of neuronal energy managment'.

assistant: **Innovation**

The intraneuronal somatodendritic ""missorting"" and aggregation of Tau are pathological hallmarks in neurodegenerative diseases (NDDs) like and Alzheimer's disease (AD), and are thought to be drivers of neurotoxicity. That NDDs manifesting with Tau ""missorting"" present with (neuro)metabolic abnormalities, often prior to pathology onset, is largely overlooked. EnergizeTau investigates the ground-breaking new idea that the somatodendritic re-sorting of Tau is a physiological response to bioenergetic challenges faced by excitatory neurons, such as hyperexcitation or energy deprivation. In its proposed role as modulator of neuronal energy management, Tau modulates the cellular energy demand through molecular interactions with key cellular functions, e.g., synaptic activity, ATP production and protein translation, and alters the neuronal metabolism. Continued energetic stress in disease results in irreversible ""silencing"" and Tau aggregation in affected neurons. Using my uniquely broad Tau expertise, we decipher how Tau interferes with energy demanding cellular functions to modulate neuronal energy household downstream of bioenergetic stress. Light-induced Tau expression and CRISPR-edited human neurons enable to study Tau's molecular actions by interactomics and single-molecule imaging, and the effects on cellular functions. Tau's influence on the neuronal metabolism is determined by longitudinal live cell metabolite imaging and spatial transcriptomics in human brains, and the impact on gene and chromatin regulation by Cut&Tag and DNA-FISH. Whether stressors converge on energy limitation as a driver of Tau re-sorting is assessed by high-content metabolite imaging. EnergizeTau introduces the metabolic component of Tau (patho)biology and generates a paradigm shift in NDD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrating Research and Standardisation' in the context of a Sixth Framework call.

assistant: **Objectives**

Standards may be considered as a link between R&D and various fields of policy, like innovation, trade and environmental policies. INTEREST aims to support Community policies by improving the interface between research and standardisation. Based on a taxonomy of research-standards-relations, the project will develop best-practice guidelines for researchers, SDOs, and policy makers on how the knowledge transfer from research to standardisation should be sup-ported, and accomplished, in different environments respective technologies. Work will start with a literature survey on the interface between research and standardisation. Then, the rationales and incentives schemes that exist within the research communities and their contacts to standardisation bodies and industry will be collected through a survey-based study. This will also reveal any co- operation patterns. Furthermore, following an indicator based approach, INTEREST will develop a two-dimensional matrix linking the technology base of companies (e.g. their patent portfolios) and their standardisation activities. Through case studies the project will analyse the internal organisational structure of the interface between research and the standards department within companies. Thus, solutions and organisational models can be identified suitable to support the transfer of research results into standards and to appropriate results from research institutions in order to transpose them into standards. In addition, the project will analyse the pros and cons of patent pools as a means to reduce complex IPR-related problems within standardisation processes. Based on these new insights, a taxonomy will be developed to characterise the typical relationships of the two dimensions. This taxonomy will be the basis to identify r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of bioassays for safety assessment of paper and board for food contact' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The work aims at the development, validation and intercalibration of a short-term biological test battery for safety assessment of food contact paper. The project represents a pre-normative research effort which will be used to launch regulatory harmonisation at EU level on the safety of food contact paper & board. The emphasis will be on cost-effective tests with toxicologically relevant end- points and sample preparation reflecting actual end uses. The tests involved have already been validated in other areas of safety evaluation. Thus the innovative aspect is to optimise them for paper & board and to develop a test battery applicable to actual food packaging. The results will be disseminated to industry, legislators and consumers and will form a common standard for safety evaluation. This will improve the competitiveness of a European industry which, using renewable raw materials, is at the forefront of sustainable development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European project for ice coring in antarctica (EPICA)' under Fifth Framework.

assistant: **Concept**

EPICA is a long-term European deep ice-core drilling project in Antarctica to derive high-resolution records of climate and atmospheric composition through several glacial-interglacial cycles. To achieve EPICA's goals it is necessary to drill at two sites, both to achieve the required resolution on different timescales and an adequate continent wide perspective. On the one hand the project will focus on an ice core from Dome C, where core retrieval has already started during the first EPICA phases and will continue during the timeframe of this proposal. On the other hand deep drilling will start in Dronning Maud Land, where the presite survey has identified a suitable drill site and where we will specifically look for the signatures of the rapid climatic oscillations found in the Greenland ice core records.