RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Learning Network for AI and Data-Powered Social Innovation and Co-Creation of Transformative Change'.

assistant: **Innovation**

Data2Action will train 10 doctoral Fellows as the next generation of transdisciplinary social innovation leaders who are capable of ethically and responsibly developing state-of-the-art data science and artificial intelligence (AI) for social good. The network will bring together leading data science and AI researchers and experts with practitioners and experts in social innovation to conduct empirical research and cascading skill-building with the following objectives:Objective 1: Establish a research roadmap and framework grounded in empirical knowledge and best practices for data science/AI to power social innovation (Data/AI for Social Good).Objective 2: Demonstrate the potential and benefits across sectors of implementing social innovations powered by data science and AI through five demonstrator projects that showcase the impact on critical societal issues: Climate, Social justice, Democracy, and Health and Ageing.Objective 3: Build capacity, Data/AI tools and methods for social innovators and entrepreneurs through an integrated open cascade training programme.Objective 4: Create new career pathways for data science and AI dedicated to social innovation.Objective 5: Provide guidance and support for practice about data science and AI for social innovation to stakeholders who contribute to social innovation: policymakers, funders, and governmental organisations and to data science and AI technology development.


**Keywords:** Data science, social enterprise, social economy, artificial intelligence, responsible innovation, health, ageing, climate, democracy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanics of the Membrane-Cortex Attachment' under Horizon Europe.

assistant: **Concept**

The interaction between the cell membrane and the underlying actomyosin cortex is vital for various cell functions and survival. This project aims to delve deeper into the intricate mechanics that govern the interaction between the plasma membrane and the cortex, which collectively constitute the cell surface in many cell types. Despite the prevailing view that the cortex completely dominates cell surface mechanics due to its increased tension, this research project aims to challenge that notion. A fundamental aspect influencing cell surface mechanics is the binding strength and dynamics between the membrane and the cortex, facilitated by membrane-cortex junction proteins (MCAs), such as ERM proteins. MCA distribution is influenced by local cortical contractions and protrusions, driven by cortical flows, which in turn may affect membrane tension and MCA dynamics. This project aims to build a comprehensive theoretical framework for cortex-membrane interaction. The framework will include several key physical elements, such as membrane and cortex mechanics, junctional dynamics, interaction with surrounding fluids, and thermal fluctuations, so that it can be applied to multiple cell types and processes. In addition, the physical model will be implemented numerically using phase field methodology to achieve accurate predictions, being open source. These predictions will be used to guide experimental measurements to better understand cell migration in neutrophils through a collaboration. This framework and simulations will help us discover new biomechanical loops essential for the emergence and migration of cell polarity. This research project is expected to have a lasting scientific impact on the field of mechanobiology by proposing a clear and generic biophysical picture of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Decoding the Structural and Functional Dynamics of HER2-HER3 in Cancer through Advanced Cryo-Electron Tomography'.

assistant: **Concept**

The HERSTRUCT project seeks to uncover the structural and functional mechanisms of HER2 and HER3, two proteins that are pivotal in driving cancer progression, particularly in aggressive breast and lung cancers. HER2 is often overexpressed in these types of cancers, leading to unchecked cell proliferation, while HER3 collaborates with HER2 to intensify the signaling pathways that sustain tumor growth and survival. Despite extensive research, the precise nature of the HER2-HER3 interaction in cancer cells, especially within their native membrane environment, remains elusive and closely linked to cancer resistance to therapies. Leveraging cutting-edge cryo-electron tomography (cryo-ET), the HERSTRUCT project aims to produce the first 3D structural view of the full-length HER2-HER3 complex in its natural membrane environment. This approach will provide unprecedented insights into how these two proteins function together at the molecular level. Functional assays will investigate how HER2 and HER3 trigger cancer-promoting signals, while mass spectrometry will identify additional molecules interacting with the complex, offering a complete view of their role in cancer progression and therapy resistance. In collaboration with leading research institutes, HERSTRUCT will explore how these structural insights can be applied to develop cancer therapies specifically targeting HER2-HER3 interactions. This effort not only fills a key gap in cancer research but also has the potential to lead to more personalized and effective treatments, particularly for HER2-positive cancers, where drug resistance is a challenge. The fellowship will provide me with cutting-edge expertise in cryo-ET and advanced data analysis, strengthening my skills and preparing me for a leadership role in cancer rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transdisciplinary Doctoral Program in Microbiome Science at the University of Naples Federico II' (CRESCENDO).

assistant: **Concept**

The microbiome is the community of microorganisms inhabiting an ecosystem along with all their genes and it plays a fundamental role in influencing the metabolic fluxes on the biosphere. Microbiome activity is essential for the life on our planet and the well-being of organisms, and research is attracting interest and investment from the industry worldwide. CRESCENDO Doctoral Programme will recruit 10 international Early Stage Researchers (ESRs) who will be involved in research and training in the Microbiome field, leading to a worldwide appreciated PhD degree valuable in terms of ESR career perspectives. UNINA applies for the MSCA-COFUND-DP through its recently established Task Force on Microbiome Studies (www.tfm.unina.it), that combines facilities and experience of more than 150 Academic scientists from 14 different UNINA Departments in the areas of Biology, Medicine, Food and Agricultural Sciences, Chemistry, Pharmacy, Engineering and Social Sciences, thus representing an ideal trans-disciplinary environment to support training and research in the microbiome field. The Programme will benefit of the participation of 21 Partner Organizations (POs) including leading international companies that are stakeholders of the microbiome research and excellent non-academic research centres. Indeed, all ESRs will spend secondment periods abroad and at least 6 months in a non-academic PO, in full integration with their Microbiome-related activities. The POs will have a key role in achieving an international, interdisciplinary and intersectoral (3-i) dimension of the DP. CRESCENDO would represent at this stage the only MSCA-COFUND project for a doctoral programme in Microbiome Science, developing trans-disciplinary Microbiome scientists with intersectoral and international experie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development and evaluation of a quantitative imaging technique for assessment of nanoparticle drug delivery across the blood-brain barrier: Applications for brain cancer therapeutics'.

assistant: **Innovation**

The partners wish to build a long term European, Industry-Academia consortium, to work on the problem of delivering therapeutic agents, e.g. for brain cancer, across the blood-brain barrier (BBB) at the efficacious dose. Current treatment options for brain cancer are limited with patients having a poor prognosis. One of the major hurdles is the BBB which prevents effective doses of drugs reaching the site of disease. There is thus a major need for technologies that can successfully overcome such a hurdle without having a negative effect on safety and tolerability. Pharmidex have developed a drug delivery system that transiently and reversibly opens the BBB to entry of compounds into the brain without inducing tissue injury. It is based on patented lipid-like structures and has been shown to deliver both small molecules and large proteins effectively into the brain. The lead delivery compound for brain cancer appears to be safe and well tolerated on the basis of pre-clinical testing. We initially seek to determine the mechanism of action of the technology for penetrating the BBB; application to different therapeutic agents as well as development of reliable brain cancer animal models to quantify efficacy of nanoparticle-based therapy using imaging technology. We believe this novel delivery technology will be a unique drug discovery tool with the potential to enhance efficacy of established agents, reduce systemic exposure of the chemotherapeutic agent, thus minimising both the on/off-target toxicity through enhancement of drug absorption at the target site. Besides its scientific objectives, OncoNanoBBB will provide a framework for cooperation and knowledge sharing between a pharmaceutical industry and two academic institutions with complementary expertise in project obj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a method to predict optimum polyurethane (PU) adhesive formulation and properties' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Polyurethanes form a particular versatile class of adhesive polymers, and their usage will continue to increase. Polyurethane (PU) adhesives include both one and two component systems, with and without solvents, heat-activated thermoplastic adhesives, cross-linkable liquid Polyurethanes and various aqueous dispersions. The type and chemical characteristics of a PU adhesive and its relationship to the formulation constituents, processing and application parameters plays a fundamental part in the performance and cost effectiveness of a PU bonded composite structure. The challenge for technical, commercial and environmental advancement, such as the need for optimum bond strengths and faster production targets, in addition to the requisite for adhesives to support more environmental safe product offerings, is placing great demands not only on the PU adhesives, but on those involved in their development and use. The research will be focused on developing a predictive modelling tool to take the guess work out of the process of selecting the optimum PU adhesive for a particular process and application, and replace it with sound scientific and technical predictions. Once the model is formulated it will be validated by SME's by a comparison between predicted and experimental data. Significant benefits to be gained from this research are the opportunities to develop innovative light weight PU bonded composites for structural and non-structural applications, improvements in processing techniques, in addition to determining new and improved PU adhesives. The consortium seeks to be as broad as possible to ensure a wide range of PU adhesives, processes and applications, as well as to SME cultures, are covered in order to give a widely acceptable methodology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'AcTivate and TRigger ACTors to deepen the function of Innovation Support Services' (ATTRACTISS), addressing dissemination and exploitation.

assistant: **Impact**

The objective of ATTRACTISS is to improve & embed competencies, approaches, instruments & governance models for Member States (MS) AKIS and specifically for Innovation Support Services (ISS) as a crucial AKIS actor, to enable them accelerating individual grassroots innovative ideas to come to fruition & to generate solutions for the transition process to more sustainable agriculture & forestry.   ATTRACTISS has the goals to (1) empower ISS & all AKIS actors, through capacity building & provision of effective methods & supportive tools, to discover innovative ideas & enable uptake in a co-creative way thereby fostering AKIS ecosystem building to support the transition to sustainable and circular agriculture & forestry systems (2) support Managing Authorities (MA) in all EU MS to organise & monitor efficient support for ISS; & (3) provide support for new actors in AKIS processes to better facilitate co-creation approaches involving farming, practitioners & research centres. ATTRACTISS achieves these goals by (1) setting up an EU wide network for ISSs that allows to connect, develop common understanding, vision & capacities about their roles & functions within the AKIS. This ultimately leads to the development of an ecosystem in favor of Multi-Actor Approaches (MAA) & innovative projects; (2) building upon and giving continuity to other previous initiatives to focus on ISSs & broaden the networks; (3) systematizing the current databases & tools for ISSs to provide a unique virtual location for tools & guidelines to support best practice; (4) providing a step change in the provision of support & training for key actors in MAA & ISS across MS which builds knowledge, understanding & confidence in the practical delivery & benefits of these approaches; & (5) enabling institutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative Aluminium filler Wires for Aircraft Structures' (IAWAS) targeting Horizon 2020.

assistant: **Abstract**

The project aims at: (1) developing new Al filler wires for WAAM and LBW of the new Al-Li alloys, (2) optimising the WAAM process and implementing suitable post-treatments, (3) characterising the microstructure, mechanical and corrosion properties of the optimised post-treated WAAM material, (4) manufacturing by WAAM two demonstrators of the targeted part and inspecting their quality.New Al wire compositions will be defined after a literature review of the different processes involved and WAAM and LBW tests on existing extrudable Al alloys.The new Al wires will be manufactured via casting and extrusion of bar-shaped semi-products that will be drawn. A parameter study will be performed for each of these processes. The new wires will be tested in the LBW and WAAM processes that will allow to select the most suitable new wire per process and to identify ways of improvement in their manufacturing route and composition. A 2nd loop of manufacturing and testing will be performed until achieving the best possible quality.In parallel, the WAAM process will be developed, optimised and completed with post-treatments. The development will be performed with the existing Al alloys until the production of the new wires.The optimised post-treated WAAM material issued from the final new wire will be characterised for analysing its microstructure and evaluating its mechanical and corrosion properties.Two demonstrators of the targeted part will be manufactured using the final new wire and the optimum WAAM conditions. A structural and geometry analysis will be performed prior to their manufacturing. Their quality will be inspected and a cost analysis will be done.


**Keywords:** Wire-drawing, aluminium alloys, additive manufacturing, laser beam welding, aircraft industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Novel microfiltration technology for emissions reduction' to be submitted under Horizon 2020.

assistant: **Abstract**

Smart Separations Ltd has developed a revolutionary filtration system that can be tailored to suit many different applications in the underdeveloped yet global €78 billion separation/filtration industry. This device will provide a more controlled, versatile, and low‐cost solution for several industries including blood donations, stem cell R&D, air filtration, and even food and drink processing. We have initially targeted the blood/stem cell and are now focusing on the air purification market, all of which have highly inadequate technologies, where we can make the greatest impact.With this project, we plan to bring the greatest impact by reducing the footprint of industrial gas emissions and thus improving quality of life, a mission that is at the forefront of our company. Emission of micro-particulates, such as PM2.5 and PM10, have been deemed a grave hazard to our health, which our technology has the potential to help tackle. With this funding, we intend to expand the already successful cellular and biological-based technology to air emissions by establishing a clear path to commercialisation through testing the new filtration system on air emissions and conducting market and IP research.We plan to gather market intelligence, develop the go-to-market strategy and business plan, and conduct a partner and IP search, with the aim to test feasibility of the new product. The world market for industrial scrubber, absorber, adsorber and biofilter systems reached £4.3bn in 2015.Incineration is the largest single market, which we plan to tackle first. Our technology has the potential to disrupt and expand the market potential through retrofitting and by simplifying and/or reducing implementation costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of antioxidants in the protection of the rhizobium-legume symbiosis during nodule initiation and senescence' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The main general objective is to study the role of antioxidant enzymes in module formation and senescence. (1) We will use electron and confocal microscopy to localize H_2O_2, ascrobate peroxidase, and superoxide dismutatses in nodule cells and tissues. (2) These techniques along with transgenic Lotus plants will be used to study the expression patterns of antioxidant enzymes from module initiation to senescence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Challenging current models of valence encoding  in the mammalian brain' (VALENCE) under Horizon 2020.

assistant: **Objectives**

In an ever-changing environment, organisms evolved to filter information and focus on stimuli that are associated with relevant outcomes. Even the simplest animals assign valence to otherwise neutral stimuli in order to survive. A positive (rewarding) valence stimulus elicits approach, whereas a negative (aversive) valence stimulus supports avoidance behaviors. Decades of research revealed that some regions of the limbic system encode valence, including the nucleus accumbens (NAc), which is considered a prime candidate to interface valence and behavior. The NAc is mostly composed of GABAergic medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 and dynorphin, and those expressing D2 and enkephalin. D1 and D2 neurons were assumed to encode opposing valence, but recent data by us and others revealed this model to be overly simplistic. That is - to date, it is still not known how valence is encoded in this region. The main goal of this project is to determine how NAc neurons encode valence. Based on preliminary data, we hypothesize that valence is encoded by distinct patterns of MSN activity. These patterns differentially signal via GABA and opioids (dynorphin, enkephalin), triggering rewarding/aversive behaviors. To test this hypothesis, we will record neuronal activity of rodents performing tasks with opposing valences, in combination with time- and spatially-resolved analysis of opioidergic transmission, using newly-developed opioid fluorescent sensors. This information will then be used to mimic/block patterns of MSN activity and opioid events in order to show causality. This cutting-edge approach will unravel with unparalleled accuracy how NAc encodes valence, the role of endogenous opioids, and how these signals are decoded in the circuit t