RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Relicts of Ancient Cellular Biochemistry in High-CO2 Subsurface Ecosystems' to be submitted under Horizon Europe.

assistant: **Abstract**

The biological conversion of inorganic to organic carbon, autotrophic CO2 fixation, is arguably the most important biosynthetic process on Earth. Having been established early in the Archean Eon, a period characterized by an atmosphere rich in CO2, this metabolism helped spark and fuel the evolution of early microbial life. Mounting evidence suggests that exceedingly high levels of CO2 select for energetically efficient CO2 fixation pathways, immensely affecting carbon cycling. We hypothesize that CO2-rich subsurface ecosystems still harbor microbes that prefer or even require extremely high CO2 concentrations; we refer to these microbes as carbodioxyphiles. Accordingly, elevated CO2 levels would impact the thermodynamics of the microbial central carbon metabolism, enhancing autotrophy and hindering remineralization of organic matter by heterotrophs. To this end, we will study microbial life in CO2-rich subsurface environments and elucidate ancient metabolic pathways rendered obsolete by the CO2 levels of most modern environments. Each of the research team’s members has contributed to prior breakthroughs in novel autotrophic pathways, environmental genomics, metabolomics, and/or the biogeochemistry of deep subsurface environments. Establishing optimal synergy in this wealth of expertise and experience, we will describe novel modes of microbial carbon fixation in CO2-rich settings and elucidate the importance of carbodioxyphily for microbial evolution. Archean Park will provide a unique window through which to study a new mode of cellular biochemistry, the relicts of primordial carbon fixation, and Earth’s earliest carbon cycle. We will comprehensively characterize the metabolic mechanisms exploited by microbes to achieve evolutionary dominion in these relict environment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ICT Platform for Holistic Energy Efficiency Simulation and Lifecycle Management Of Public Use Facilities' under Seventh Framework.

assistant: **Concept**

HESMOS will achieve an industry-driven holistic approach for sustainable optimisation of energy performance and emissions (CO2) reduction through integrated design and simulation, while balancing investment, maintenance and reinvestment costs. The objective is to close the gaps between existing intelligent building/facilities data so that complex lifecycle simulation can easily be done in all design, refurbishment and retrofitting phases where the largest energy saving potentials exist. This will be achieved by (1) extending existing BIM, energy simulation and cost calculation tools, so that they can seamlessly exchange the required data, (2) integrating advanced energy simulation tools into the design and FM process, so that BIM-CAD and FM tools can be used as building energy simulator and gap identifier, (3) developing new applications that can visualize building performance in easy to understand way and can quickly display impacts of changed building/space parameters, (4) developing new Cockpit functionality" in BIM-CAD on EPBD basis to provide fast feedback of the impact of design parameters on lifecycle energy performance, (5) extending BIM-CAD to model and manage buildings and surrounding areas, and (6) ex¬tending BIM-CAD by web services to act as Integrated Virtual Energy Laboratory (IVEL) enabling the study of design and retrofitting alternatives concerning energy performance and total costs. An innovative SOA around the kernel functionality of BIM-based CAD/FM will be applied. Information interoperability will be achieved by enhancing BIM with energy and emissions features to a new sharable eeBIM. Intelligent access methods and a specialised ontology will be developed to enable multi-system integration and management of material, climate and product databases a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Study of a novel degradable hydrogel of the pla/peo/pla type adapted to simultaneous delivery of hydrophilic and lipophilic drugs' (1994-1998).

assistant: **Innovation**

Research objectives and content 1. Synthesis of PLA/PEO/PLA or PCL/PEO/PCL triblock copolymers. 2. Characterization of the copolymers by various analytical techniques. 3. Formation of hydrogels in the presence of a drug. 4. Study of the release of the drugs. The synthesis of the triblock copolymers will be prepared by ring-opening polymerization of DL-lactide or e-caprolactone in the presence of poly(ethylene glycol), using no-toxic Zn metal or calcium hydride as co-initiator instead of the stannous octoate which is no really convenient for human therapy The composition of the copolymers will be varied by adjusting the polyester/polyether ratio. Degradable hydrogels will be prepared in the presence of the drug by the method established in the laboratory. The study of the release of the drug from the degradable hydrogels will be carried out at 37 0C in a pH 7.1 phosphate buffer or in pure water. In a first stage, albumen will be taken as a model compound of large size proteins. This model protein will be entrapped in the hydrophilic part of the hydrogel and its release characteristics will be investigated. In a second stage, progesterone or oestradiol will be entrapped in the lipophilic microphase formed by PLA nodules and release characteristics will be investigated. In the last phase both model compounds will be entrapped simultaneously and release characteristics investigated. Training content (objective, benefit and expected impact) The candidate will be trained in polymer science including synthesis and characterization by usual methods. The candidate will also be trained in drug delivery using new galenic approaches based on degradable and bioresorbable polymers. The applicant will have the opportunity to contribute to in vivo pharmakinetics investigations. The res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A Coordination and Support Action to prepare UNCAN.eu platform'.

assistant: **Concept**

The 15-month coordination and support action “4.UNCAN.eu” will generate a strategic agenda to launch UNCAN.eu, a European initiative to UNderstand CANcer proposed by the Mission Board and the European Beating Cancer Plan. This research agenda will be built with the final aim of achieving a new breakthrough in cancer prevention and treatment that will contribute to saving European citizens’ lives and help ensuring an optimal quality of life to disease survivors. To reach a new level of understanding, UNCAN.eu will take advantage of recent advances in research data generation and data sciences. Reliable, high-quality cancer research data generated by experimental model analysis and collected from longitudinal follow-up of cancer patients will be shared and integrated at an unprecedented scale within a Federated Cancer Research data hub, in the context of the General Data Protection Regulation. This information will be used by relevant players in Europe and beyond to address urgent and essential scientific and medical challenges in cancer prevention, early diagnosis, treatment and survivorship, in males and females of various ages. These challenges, identified in close interaction with European patients and citizens, will be tackled through competitive, ambitious and innovative, cross-border and trans-disciplinary research programmes built in a problem-solving manner. The definition of challenges will integrate inequalities in cancer research across regions and member states in order to boost the research potential of less-developed regions in Europe. Players will be committed to open science principles, including FAIR (findable, accessible, interoperable, and reusable) guiding principles for scientific data collection, management and stewardship. The new understanding gai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Forms of Labour: Gender, Freedom and Experience of Work in the Preindustrial Economy' (FORMSofLABOUR) under Horizon 2020.

assistant: **Objectives**

The history of labour and its role in Europe’s preindustrial development has very largely been the history of adult men. FORMSofLABOUR seeks to put other workers in the picture, particularly women and servants, not simply by ‘adding them on’ but by showing how a full understanding of women’s work and of service offers a radical critique of existing approaches to work and to the idea of free labour. It focuses on England in the period 1300-1700 viewed in a comparative Western European perspective, and addressed these issues through three themes. (1) A revolutionary research technique which collects evidence of work tasks from court records to simulate a time-use study is used to explore the experience of work. This technique allows the work activities of women and men, young and old, employees and family members to be illuminated, with evidence of tasks, location and timing of work, creating an entirely new perspective on England’s early modern economy. (2) The theoretical underpinnings of the history of women’s work in the preindustrial economy are explored, reassessing key debates using interdisciplinary perspectives from economics and political science, as well as new archival evidence from themes 1 and 3. Gendered work patterns are viewed through the lens of freedom, rather than patriarchy, to create a step-change in our understanding of gender and work. (3) The issue of the extent to which labour was ‘free’ after the end of serfdom is interrogated through a careful examination of the range of forms of labour and the nature of labour laws, using a variety of archival evidence combined with a comparisons with serfdom and slavery, and the adoption of insights from development economics and anthropology. Together these interlocking themes create a new history of work in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Antibody-based therapy against Streptococcus pneumoniae'.

assistant: **Objectives**

The pneumococcus (Streptococcus pneumoniae) is the predominant cause of community-acquired pneumonia and causes otitis media, sinusitis, meningitis and sepsis. The increased serotype replacement and antibiotic resistance, reinforces the necessity of developing alternative treatment strategies for this pathogen. Monoclonal antibodies that boost the host immune system are attractive candidates to fight the high rates of morbidity and mortality due to this important human pathogen. Antibodies recognizing bacterial surface structures could be used to trigger activation of the complement cascade and subsequent bacterial killing. However, no significant progress has been made in the direction of immune system boosting therapies against pneumococci, mainly caused by our limited insights into antibody-driven immune activation on bacteria. With this proposal, I aim to study whether complement-enhancing monoclonal antibodies can be used as treatment against pneumococci. Through a combination of advanced sequencing approaches and functional complement activation assays, I will first identify antibodies against S. pneumoniae driving potent complement activation. Then I will use my expertise in S. pneumoniae infection models to unravel whether monoclonal antibodies eliciting complement are effective in pneumococcal killing in vitro and in vivo. The work proposed represents a first systematic approach to design effective therapeutic antibodies against S. pneumoniae that function via enhanced complement activation. Altogether, a better understanding of antibody-dependent complement activation on bacteria will create new avenues for the design of new therapeutic strategies to improve both antibody therapies and vaccination strategies in diseases caused by pathogenic bacteria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Study of rna components by the synthesis of small molecules', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The proposed research is intended to exploit RNA as a pharmaceutical target by the synthesis of rationally designed small molecules as lead structures and could potentially result in the development of novel antibiotics. The work will initially focus on substrates that bind specifically to the ribonucleic acid (RNA) components of the bacterial ribosome, which is a validated target for many known antibiotics. Additionally, technologies currently used for the global analysis of protein function, exemplified b y the biotin-small molecule conjugates, will be explored for the identification of novel RNA components as potential targets for small molecule interactions with therapeutic significance.Finally, exploration of RNA tertiary structure will be performed by the synthesis of dynamic libraries", where the individual final products will be generated in the presence of the biological target, resembling the outcome of a natural selection. Our approach will be expandable to other RNA-domains, like the GTPaseassociated domain in 23S rRNA, target of the antibiotic thiostrepton, or the internal ribosome entry sites (IRES), which are important targets for the treatment of viral pathogens such as polio and hepatitis C. This project represents an interdisciplinary approach, comprising of synthetic, spectroscopic, biological, and computational studies and is expected to elucidate the pharmacological profile of various RNA components and increase our understanding for their individual function.In addition to the obvious training opportunities for young researchers in the different scientific fields involved, its successful completion will place EU in the lead of the world stage in the field of RNA, will create new opportunities for the development of biotechnology and pharmaceutics a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanomechanics of natural materials from combining tomography and finite element modelling' under Seventh Framework.

assistant: **Concept**

Porous sedimentary rocks compose a large part of the European coastline and are major oil reservoirs in Europe, yet little is not known about their nanoscale structure and mechanical properties even though these parameters are linked to macroscale behaviour. The aim of TOMOMECH is to combine X-ray tomography and finite elements modelling (FE) on the nanoscale to make predictions about the stability of e.g. chalk cliffs and the remaining oil in depleting reservoirs. My model for determining stability will be versatile, which I will demonstrate by applying it to biomineralised shells as well, to elucidate nature's design strategies. The combination of tomography and FE has been employed successfully before to examine the structure and functionality in trabecular human bone on the microscale. A main objective of TOMOMECH is to transfer this approach to the nanoscale and adapt it for determining pore structure in sedimentary rocks. The results will be applicable to coastal protection, oil production and biomimetic materials. Through a direct connection to industrial partners, a focus on applicability is ensured. My background in Physics, combining X-ray techniques and modelling from the molecular to the continuum scale will underpin this project but I will also benefit from the training in new nanoscale characterisation techniques that I will receive. Interdisciplinary research has been a major topic in my career and TOMOMECH will give me the opportunity to further broaden my scientific background. The approach I will develop and the chance to run my own project will give a good push in my future career. Mentoring by my host, Prof. Stipp, who is an expert in nanoscale characterisation, and interaction with the Nano-Science Center, Copenhagen, will ensure progress, help incr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Case study of analysis and re-engineering of railway allocation systems' under Fourth Framework.

assistant: **Concept**

British Rail (BR) has a number of legacy applications associated with Train Operations. To enable these systems to continue to provide support for key business processes it is vital that they be modern, flexible and easy to use. Re-engineering the existing applications is seen as the best way of achieving this. No process-based metrics currently exist within BR to allow this type of development to be carried out in a controlled manner. The PIE will run against the first such development, providing metrics both for later stages of the baseline project and for future re-engineering work. Re-engineering these systems will only be successful when it has been proven possible to predict the time and cost of each application. Without such metrics it is likely that no further such projects will be undertaken due to the unknown cost and time scale implications. This would leave a number of systems in key business areas which use out of date technology and which would be increasingly difficult to integrate into the portfolio of systems operated by train operators to manage the train service.THE EXPERIMENTThe PIE will be a parallel project to the baseline re-engineering project. The baseline project is divided up into 4 phases, Analysis, Development, Testing, and Implementation. For each of these phases estimates for each of the activities will be produced and the baseline project executed. Actuals will be captured for the work taken to complete each phase of re-engineering, and used to refine estimates for the succeeding phases of the baseline project. The deliverables from the experiment at each phase of the baseline project will be metrics, procedures and standards appropriate to the activities in that phase, which can be used for re-engineering legacy systems.The baseline proj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'TArgeting Platelet Adhesion receptors in thrombosiS'.

assistant: **Innovation**

TAPAS will position Europe at the forefront of innovative research to prevent thrombosis and thromboinflammation, and will train a uniquely-qualified cohort of ESRs in a highly intersectorial and multi-disciplinary programme that will equip them with the knowledge and transferable skills required in the broad biomedical sector. The research will focus on platelets which are small cells in the blood that play a critical role in prevention of excessive bleeding following injury (haemostasis). Activation of platelets in diseased vessels gives rise to thrombotic disorders such as heart attack and stroke, two of the major causes of morbidity and mortality. Patients at risk of thrombosis are treated with medicines that inhibit platelets for life, but many patients still undergo thrombotic episodes or encounter serious bleeds through diminished haemostasis. There is thus an urgent need for novel and safe anti-platelet medicines that powerfully target thrombosis but preserve haemostasis.  In TAPAS, an original and innovative approach will be undertaken to find new ways to target thrombosis through co-operation of academic experts in distinct disciplines with key skills from the private sector. TAPAS will generate and integrate knowledge from analytical complex ‘omics’, advanced microscopy, cell biology, microfluidics, in vivo models, contemporary systems biology and high throughput screens to identify new targets for therapeutic intervention and novel lead compounds or biologics. The research skills developed in this programme are applicable to other complex diseases and represent essential training in modern day research for the next cohort of academic and private sector scientists that are able to convert complex biological understanding into new medicines. The shared knowled