RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'REsearch INfrastructures FOR Citizens in Europe'.

assistant: **Innovation**

Large Research Infrastructures in the field of frontier Physics have opened new observational windows to the universe and explore the structure of matter in extreme detail. These advancements require high levels of expertise and sophistication. On the other hand, society, lacking this level of expertise, merely observes these developments through outreach activities but does not actively contribute in the development of new scientific knowledge. This fact induces a gap between frontier science and society that can spawn misconceptions about the content, context and mission of public funded frontier science.  The REINFORCE project comes to answer to the questions: a) Can citizens contribute in the development of new knowledge in frontier science? b) Can citizens apply this new knowledge to solve societal problems? c) How can we integrate citizen feedback? REINFORCE goes beyond outreach programmes and aims to minimize the gap between Society and Large Research Infrastructures in the field of Physics through the: i) development and implementation of 4 cutting-edge Citizen Science projects in the fields of Gravitational Waves, Neutrino Astronomy, Particle Physics and Cosmic Ray interplay with geoscience and archaeology with citizens: Citizens will analyze data and support the optimization of sensitive detectors in order to enhance their discovery potential. ii) implementation of a participatory design in citizen science: Communities of citizens will be developed, trained and empowered to contribute in the scientific mission of Large Research Infrastructures. iii) effective inclusion of sensitive citizen groups as well as the active interaction with secondary and tertiary education. iv) Aggregating best practices in a pan-European policy roadmap. REINFORCE aspires to engage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EXploration of TerREstrial Mobility and Ecology in Crocodylomorphs' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Fully understanding the ecology and evolution of extinct species requires analysis of their locomotor abilities, which are interactions with their environment that correlate with the morphology of the postcranial skeleton in complex ways. Locomotor abilities provide valuable insights into potential behaviors and ecological roles, such as how species hunted, avoided predators, selected habitats, and found mates. Crocodylomorpha, which nowadays comprises only 28 species of semi-aquatic ambush predators  namely crocodylians  is an important group for studying ecology and the processes of evolution over Deep Time, since Crocodylomorpha colonized a variety of environments and displayed a wide range of sizes and shapes for over 200 My. The aquatic clades Dyrosauroidea and Thalattosuchia, two notable examples of this rich diversity, exhibit clearly dissimilar anatomy, especially compared to modern crocodylians, implying strongly divergent locomotor abilities and behaviors, notably an inferior range of terrestrial gait. This divergence allows for functional hypotheses to be tested; hereby I hypothesize that habitat has a strong impact on the morphology of the crocodylomorph skeleton, which can be used as a basis to infer habitat on the scale of Crocodylomorpha (through quantitative proxies). As such, the primary goals of EXTREME CROCS are to use computational biomechanics, joint mobility analyses, and geometric morphometrics on entire skeletons to assess biomechanical form and function in extinct Crocodylomorpha and explore how the morphology of the appendicular skeleton is linked to terrestrial and swimming locomotor abilities. I will produce 3D musculoskeletal whole-body models of six species and use these to compute predictive simulations of optimal locomotor performances. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Event-based LEarning, Vision, And conTrol for Embodied systems' in the context of a Horizon Europe call.

assistant: **Objectives**

Computing with neuromorphic hardware, learning with spiking neural networks, and sensing with event-based cameras are recentexamples of new technologies that have the potential of revolutionizing the learning and control capabilities of digital automationand robotics. They offer a novel and unique opportunity to make machine intelligence more efficient, more embodied, and moreresilient. Event-based technology will enable online learning over multiple temporal and spatial scales, sensors with embodied adaptiveintelligence, and improved translation of rhythmic features of animal intelligence in machines. Yet the discipline is still in its infancyand technology lies ahead of methodology.While the potential of event-based information processing has been researched separately in neuroscience, in algorithmic science,and in electronic circuit design, the deployment of event-based machine intelligence across the broad spectrum of automationtechnologiesrequires a much higher level of integration. The sparse and asynchronous nature of event-based information impacts the design allthe way from the sensing and computing hardware to the perception and decision-making functionalities of the entire system.The Doctoral network ELEVATE proposes to educate a new generation of information engineers able to address those challengesthrough a unique environment combining leading international recognition in complementary scientific disciplines, a diverse rangeof companies at the forefront of event-based technology, and a culture of machine design inspired by the challenge of furtherdigitalizing our societies with a focus on sustainability, security, and ethics.


**Keywords:** neuromorphic engineering, event cameras, neuromorphic computing, event-based technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rapid design system for the footwear industry' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This project proposes to design and produce a pre-production design development data base to improve the speed and efficiency in bringing a new shoe design into production and hence to the market place. By providing an easy to use 'design by adaptation' capability, the system should encourage our designers to develop more integrated and rationalised design concepts. This should reduce part counts, maximise the returns from previous investments in tools and operator training, and improve production efficiency. The system will also hold approved production quality control measures for various combinations of materials and/or shoe constructions to allow automatic generation of the necessary instructions. This will assist companies win quality accreditation and improve competitiveness. The system will be developed for use by people with little previous experience of computers. It it will be adaptable so that new component and construction categories may be accommodated as they evolve with fashion. This will ensure that the software will be configurable for a range of individual company needs. The information held by the design development data base system will be separate but compatible with other computer applications in use. This provides for holding prototype design details for materials and components which need not exist in the production systems until the style is approved for bulk production. For companies in supply partnerships which produce designs commissioned by retailers, the system will be suitable to use as an interactive catalogue to aid negotiations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy-efficient piezo-MEMS tunable RF front-end antenna systems for mobile devices' (EPAMO) targeting Seventh Framework.

assistant: **Abstract**

Future wireless communication systems need to cope with the increased number of frequency bands and advanced mobile phone standards supporting high data rates. At the same time mobile phone systems have to become more energy-efficient in order to contribute to the Grand Challenge “CO2-reduction”. The EPAMO project will address both aspects by exploring and implementing multiple innovative process and testing technologies to realise an adaptive antenna front-end system for 4G mobile phones. Due to closed-loop antenna tuning the radio power levels can be reduced in the mobile phone by more than 50%, in the base stations by at least 10%. It is estimated that the implementation of this technology has a global energy-saving potential of more than 10.000 GWh per year. EPAMO has the objective to explore the potential of unprecedented ultra-high density RF-MEMS switch arrays to be integrated in an energy-efficient agile RF transceiver with reconfigurable antenna. Key cross-cutting More-than-Moore and heterogeneous integration technologies are high-force piezoelectric MEMS actuators based on Lead Zirconate Titanate (PZT) thin films, high reliability metallic contact switches, and low-loss silicon and composite glass-silicon 8” wafer substrates.  Fine pitch through-wafer vias will allow a high-density 3D system integration in ultra-small RF module substrates with integrated components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Circuit mechanisms underlying dynamic spike time synchronization in mouse motor cortex' (M1SYNC).

assistant: **Concept**

Direct electrical stimulation of the motor cortex is sufficient to trigger movement, but the mechanisms by which neurons in this cortical region intrinsically encode motor output continue to be resolved. Spontaneous activity in the motor cortex is surprisingly sparse, and the precise temporal synchronization of this weak and distributed activity may be critical for efficient cortical communication. The fact that spiking within cortical motor circuits naturally reverberates within rhythmic oscillations demonstrates that exquisite mechanisms for controlling spike timing do exist. Moreover, these brain rhythms display a transition from beta- (15-30 Hz) to gamma-frequency oscillations (30-120 Hz) during movement planning and initiation, and even during motor imagery, suggesting further that flexible control of spike time synchronization may be an important feature of cortical coding. This project will use optogentic control of neuronal activity in order to elucidate the circuit mechanisms and function of beta/gamma-frequency oscillations in the mouse motor cortex. The objectives are to (i) determine how the pattern of network synchronization reflects the spatial profile and intensity of light-induced neuronal activity in acute cortical slices, (ii) resolve the synaptic and circuit mechanisms underlying the activity-dependent tuning of these cortical networks, and (iii) determine how fast network oscillations influence sensorimotor integration of sensory-evoked responses in vivo. The synchronization of brain activity is disrupted in numerous neurological and mental disorders, and thus resolving its role in cortical circuit processing could be key to understanding both brain function and dysfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mutations in the hepatits c virus genome - a cause for interferon treatment failure' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content The aim of the project is to investigate whether mutations affecting the CD4+ T helper epitopes of the hepatitis C virus (HCV) core and envelope proteins result in viral escape and relapse following interferon-alpha treatment. The majority of patients with chronic hepatitis C who initially respond to interferon subsequently relapse and the reasons are not clear. Recent data show that a strong cellular immune response to HCV proteins is important for viral clearance. HCV displays a high mutation rate and the role of mutations in altering the immune response is not known. The study will focus on patients with chronic hepatitis C who relapse after interferon treatment The HCV core gene and the hypervariable region will be amplified from paired samples before and after treatment for each patient. Peptides spanning the immunodominant epitopes will be synthesised according to the HCV sequences obtained for the two time points. The proliferative response and cytokine release of CD4+ T helper cells will be investigated against the different peptides to test the hypothesis that emerging mutations aborgate the T cell response and contribute to viral persistence. Training content(objective,benefit and expected impact) The proposed project will involve training in molecular and immunological techniques ( DNA sequencing, cell cultures and lymphoproliferation assays)and with the education programme of University College London will form an excellent foundation for a future academic career.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In vitro high resolution reconstitution of autophagosome nucleation and expansion catalyzed by ATG9' under Horizon 2020.

assistant: **Concept**

Autophagy is a conserved, lysosomal-mediated pathway required for cell homeostasis and survival. It is controlled by the master regulators of energy (AMPK) and growth (TORC1) and mediated by the ATG (autophagy) proteins. Deregulation of autophagy is implicated in cancer, immunity, infection, aging and neurodegeneration. Autophagosomes form and expand using membranes from the secretory and endocytic pathways but how this occurs is not understood. ATG9, the only transmembrane ATG protein traffics through the cell in vesicles, and is essential for rapid initiation and expansion of the membranes which form the autophagosome. Crucially, how ATG9 functions is unknown. I will determine how ATG9 initiates the formation and expansion of the autophagosome by amino acid starvation through a molecular dissection of proteins resident in ATG9 vesicles which modulate the composition and property of the initiating membrane. I will employ high resolution light and electron microscopy to characterize the nucleation of the autophagosome, proximity-specific biotinylation and quantitative Mass Spectrometry to uncover the proteome required for the function of the ATG9, and optogenetic tools to acutely regulate signaling lipids. Lastly, with our tools and knowledge I will develop an in vitro reconstitution system to define at a molecular level how ATG9 vesicle proteins, membranes that interact with ATG9 vesicles, and other accessory ATG components nucleate and form an autophagosome. In vitro reconstitution of autophagosomes will be assayed biochemically, and by correlative light and cryo-EM and cryo-EM tomography, while functional reconstitution of autophagy will be tested by selective cargo recruitment. The development of a reconstituted system and identification proteins and lipids which ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '60th Nobel Laureate Meeting at Lindau - Interdiscinplinarity, Internationalisation, and Excellence' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Since 1951, Nobel Laureates meet in Lindau during the summer for a week of open-minded exchange, exploration of new horizons and connecting to the world’s most promising young academic researchers.In 2010, the 60th Nobel Laureate Meeting will take place from June 27th to July 2nd at Lake Constance, bringing together Laureates and Best Talents from all disciplines in natural sciences. This 3rd Interdisciplinary Meeting (after 2000 and 2005) will connect, inspire and educate almost 70 Laureates and over 650 young researchers.Based on a globally unique approach, this international forum of excellence perfectly embodies the four goals of the 7th Framework Programme:•To gain leadership in key scientific and technology areas•To stimulate the creativity and excellence of European research•To develop and strengthen the human potential of European research•To enhance research and innovation capacity throughout EuropeIn combination with its outreach activities such as the exhibition on the Isle of Mainau “Discoveries: Energy”, focusing on the topics of environment and sustainability, the Tiny Tots Center and the Mediatheque with scientific lectures from six generations, the Lindau meetings serve as one of the most successful brain gain initiatives for Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MetaCil: Unveiling the molecular interplay between primary cilia and metabolism in cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

The primary cilium (PC), a ubiquitous microtubule (MT)-based organelle that protrudes from the apical surface of most human cells, is essential for transducing signals required for growth control. Many cancers, including prostate cancer, exhibit near- complete loss of cilia during the early stages of oncogenic transformation. Novel strategies are urgently needed to treat the most aggressive and worst prognosis prostate cancers, the most common cancer and 2nd leading cause of cancer death for men. The host lab data indicate that the hypoxia-induced cleaved form of the mitochondrial outer membrane channel VDAC1 is a critical regulator of both glycolysis and ciliogenesis. This proposal seeks to delineate the molecular mechanisms involved in the cross-talk between metabolic reprogramming and PC in hypoxia in prostate cancer (PCa) models according to the following workpackages (WP): WP1 addresses 1) the relevance of VDAC1 in the interplay between metabolism and ciliogenesis in PCa in hypoxia and 2) the identification of key regulators (i.e key glycolytic enzymes) of both PC signaling and metabolism. WP2 investigates the close proximity between VDAC1 and PC and test the hypothesis that some mitochondria serve as an alternative microtubule organizing center. The structural and molecular determinants required for MT to emanate from mitochondria and their functional relevance in response to hypoxia will be defined. This WP combine state-of-the art expansion microscopy, in vitro and in silico techniques and will benefit of the scientific expertise from both the host lab and my personal networks. WP3 targets the discovery of ligands that bind specifically at the interface of VDAC1 and MT nucleation complexes to disrupt the interaction and confirm the pharmacological relevance of b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Microevolutionary and population dynamic processes in parasitic helminths' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

This project makes full use of the experience, skills and contacts acquired during my postdoctoral stay abroad, allowing me to combine the expertise of three recognized institutes: The Catholic University of Leuven, Belgium, the Institute of Tropical Medicine, Belgium, and the Natural History Museum London. This combination unites basic biological science, fisheries and aquaculture (KUL), parasitology and epidemiology (ITG and NHM), and genomics and population genetics (KUL). Such a multidisciplinary approach is becoming increasingly important in grasping complex problems like the epidemiology of parasitic diseases.Despite its enormous importance and huge potential, population genetic studies on helminth parasites are very rare. Amongst the three major components of a host-parasite interaction, the abiotic environment, host genetics and parasite genetics, the latter has been the least studied. We need to know how genotypes are distributed within and among parasite populations, and the epidemiological factors that determine these distributions. Here we apply a comparative approach by concentrating on two parasite groups that differ in important life history traits: Gyrodactylus spp. are ectoparasitic on teleosts (causing major problems in aquaculture), and Schistosoma spp. are endoparasites of mammals (of which humans, causing Bilharziosis). We will study the population genetic structure by means of microstatellite studies and sequencing of variable mtDNA fragments. By comparing the obtained results, we will be able to identify the factors that structure parasite populations.Apart from answering fundamental questions necessary to study the theory of speciation, there will be an added applied value to the obtained results. Uncovering transmission dynamics is crucial in st