RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Next-generation equipment tools and mission-critical strategies for First Responders' in the context of a Horizon 2020 call.

assistant: **Objectives**

With the evolving threat of climate change and the consequences of industrial accidents to becoming more severe, there is an increasing need for First Responders to access reliable and agile information management systems that offer as higher Situational Awareness and better Common Operational Picture. To match with current trends, the RESPOND-A project aims at developing holistic and easy-to-use solutions for First Responders by bringing together the complementary strengths of its Investigators in 5G wireless communications, Augmented and Virtual Reality, autonomous robot and unmanned aerial vehicle coordination, intelligent wearable sensors and smart monitoring, geovisual analytics and immersive geospatial data analysis, passive and active localisation and tracking, and interactive multi-view 360o video streaming. The synergy of such cutting-edge technological advancements is likely to provide high-end and continuous flows of data, voice and video information to First Responders and their Command & Control Centres for predicting and assessing the various incidents readily and reliably, and saving lives more efficiently and effectively, while maximising the safeguarding of themselves, before, during and after disasters. To this end, RESPOND-A envisions at exercising First Responders for getting familiar with the project technological outcomes, and demonstrating their real-world performance and effectiveness in the classified training facilities of our Responder Partners under hydrometeorological, geophysical and technological disaster scenarios.


**Keywords:** Common Operational Picture, Mission Critical,  First Responders, Situational Awareness, Natural and man-made hazards
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Arrhythmogenesis in Dilated Cardiomyopathy: Role of Mechano-Electric Coupling'.

assistant: **Objectives**

Heart failure is a major cause of death in the Western world, with an estimated prevalence of 2-3\% of the population. A subgroup of heart failure patients is characterised by dilated cardiomyopathy (DCM) which results in substantial morbidity and mortality due to progressive mechanical pump failure (70\%) or sudden cardiac death from ill-predictable electrical disturbances (30\%). DCM is commonly linked to mutations encoding cytoskeletal proteins, but our understanding of why a loss of cardiac myocyte cytoskeletal integrity in inherited DCM phenotypes results in detrimental changes to calcium handling, and how this causes arrhythmias and sudden cardiac death, remains limited. Human studies have associated genetic mutations and loss in the cytoskeletal protein filamin C (FLNC) with arrhythmogenic DCM and sudden death. To explore the biomechanical and mechano-electric mechanisms by which FLNC deficiency leads to mechanical and electrical dysfunction, I will use experimental and mathematical models that span multiple spatial and temporal scales from the protein level up to the whole heart. I hypothesise that FLNC regulates myofilament lattice spacing and that loss of this structure leads to impaired contractile force development by the sarcomere. I postulate that these perturbations in mechanics may contribute to the generation of substrate for the induction and maintenance of lethal ventricular arrhythmias via a variety of mechano-electric coupling mechanisms. Particularly, stretch-induced alterations may affect cardiomyocyte electrophysiology, which may contribute to both the trigger and the substrate for arrhythmias. Thus, altered myocardial mechanics in the FLNC-null mouse model of DCM may contribute to the triggering or maintenance of life-threatening reentrant ventr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'De-Coding Adhesion, Degradation and Immunomodulation Properties of Self-Assembling Peptide Hydrogels for Programmed Tendon Regeneration' (DeCodeGels), addressing dissemination and exploitation.

assistant: **Impact**

Despite recent advances there is still a clear need for injectable and regenerative biomaterials that can spatiotemporally modulate the inflammation and, in parallel, induce the desired regenerative pathways. Usually, biopolymeric hydrogels need a narrow and somewhat opposite set of physical and biological properties which allow for their degradation, adhesion as well as immune cell invasion to allow complete tissue regeneration. To resolve this issue, following my unique interdisciplinary expertise, I plan to develop new injectable self-assembling peptides (SAPs) biomaterials that simultaneously: i) possess improved adhesion to local tissues in vivo, ii) exhibit controlled degradation matching the desired regeneration outcome, and iii) allow tissue regeneration by enabling controlled immune cells invasion and progression of inflammation from neighbouring tissues. The basic rules for decoupling these properties will have broad implications to the biomedical community. Following injury, inflammation is the trigger of tissue repair, however, chronic inflammation is detrimental. The persistent inflammatory nature of tendinopathy contributes to localized tissue damage, often developing to a low-grade chronic inflammation with recurring tears. Unlike conventional anti-inflammatory therapies that merely address symptoms, DeCodeGels introduces an innovative therapeutic strategy utilizing temporally modulating SAPs biomaterials. This groundbreaking approach aims to i) initially induce a controlled, localized pro-inflammatory state, then ii) gradually transition this state to an anti-inflammatory environment over time to ultimately achieve a dual-purpose therapy that reverses chronic inflammation and promotes therapeutically driven healthy tissue regeneration. This single, multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'High-throughput directed evolution to engineer thermostable therapeutic proteins'.

assistant: **Objectives**

The project will establish a novel high-throughput directed evolution platform for evaluating large libraries of therapeutic protein (TP) variants for increased thermostability, slower global or local unfolding rates, and minimised aggregation propensity. This will require several recent advances to be coupled into a single system. Directed evolution can be carried out by encapsulating single plasmids, each encoding a unique protein variant, into droplets of an emulsion, then using cell-free expression to generate the protein in each droplet.  This project will extend this approach to incorporate non-natural amino-acid fluorophores into the protein to create a FRET-based signal that would give a direct report on protein expression levels, and then also on the stability (denaturation) of the protein (FRET-loss) upon stimulation by heating. Such heating will initially be applied to droplets in bulk for defined periods of time to allow global unfolding and aggregation, and then recooled prior to FACS sorting for variants that best retain the FRET signal. Aggregation under native (low temperature) conditions is known to be linked to local protein unfolding events that are relatively rare. To extend the screening approach for directly evolving slower local unfolding events, a fast IR-induced temperature-jump perturbation will be used to cause only local unfolding prior to FACS sorting.  Such a platform would be used to directly evolve TPs with increased thermostability (slow global unfolding), and then slower local unfolding, which will combine to decrease aggregation propensity. An enzymatic system (bovine enterokinase) will be used initially to establish and validate the set-up, taking advantage of the simple fluorescent assay for enzyme activity. Once established, the set
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pulses & health-state of the art and communication' (1998-2002).

assistant: **Innovation**

There are apparently many evidences that pulses could be highly beneficial for health of European consumers. Indeed they provide the consumer with high protein (from plant origin), low fat, high starch (slow carbohydrate type) and high fibre food. In order to increase pulse consumption in Europe and improve health, it is important to check the evidences of these potential health benefits to properly publicize them with sound arguments. Therefore, first, a workshop (about 20 persons) will enable nutritionist's experts to discuss scientific knowledge on the basis of their own experience but also on a critical and exhaustive analysis of the literature. A review will be written by each of the speakers and will be published as a book. Second, a conference will be organised to communicate towards consumers, health professional players, food industrialists, producers and journalists. A leaflet summarising the main outputs of the meetings will then be available for a wide dissemination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ultrafast-fluorescence lifetime imaging microscopy on nucleosome of eukariotic cells.' (1998-2002).

assistant: **Concept**

Using picoseconds- FRET imaging microscopy on fluorescent-tagged DNA and histone molecules, the role of acetylation on the biophysical properties of chromatin is speculated by studying the structural changes in the nucleosome of eukaryotic cell nucleus.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Neuronal and glial fate of neurosphere forming cells from olfactory neuroepithelium' (NSFCSTRANSPLANTATION).

assistant: **Innovation**

Recently, the design of new brain repair strategies based on stem cell transplantation has received a tremendous amount of attention.This has been due to the increased incidence of neurodegenerative diseases and the absence of effective chemically based therapies. In this context the potential use of stem cells for transplantation appears as a promising alternative to restore lost cells (i.e. neurons or oligodendrocytes) in the central nervous system (CNS).In this context, adult neural progenitors derived from olfactory neuroepithelium could constitute an excellent candidate.Olfactory neuroepithelium is a unique source of adult human progenitors, which can be obtained from an individual without invasive surgery. These cells have the capacity to continually replace damaged neurons and glia throughout life; they can be amplified in vitro and create neurospheres and they can adopt a neuronal or glial fate depending on environmental factors. They survive, integrate and are functional when transplanted into a rat model of injured spinal cord.We propose to further study olfactory neuroepithelium cells and to develop in vitro amplification and differentiation procedures to obtain a pure population of committed progenitors for transplantation into damaged CNS or for use in drug research, pharmacological evaluation and gene manipulation. As a first step to use adult olfactory progenitors to facilitate CNS repair, we propose to test the capacity of these cells to differentiate into dopaminergic phenotype and investigate their restorative capacity when grafted into  a denervated striatum.Analogously, the potential of adult olfactory progenitors to differentiate into oligodendrocytic phenotype and to restore oligodendrocytes will be evaluated in hypomyelinated corpus callosum of mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Soluble dietary fibre: unraveling how weak bonds have a strong impact on function' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Dietary fibres are recognized for their health promoting properties; nevertheless, many of the physicochemical mechanisms behind these effects remain poorly understood. While it is understood that dietary fibres can associate with small molecules influencing, both positively or negatively their absorption, the molecular mechanism, by which these associations take place, have yet to be elucidated We propose a study of the binding in soluble dietary fibres at a molecular level to establish binding constants for various fibres and nutritionally relevant ligands. The interactions between fibres and target compounds may be quite weak, but still have a major impact on the bioavailability. To gain insight to the binding mechanisms at a level of detail that has not earlier been achieved, we will apply novel combinations of analytical techniques (MS, NMR, EPR) and both natural as well as synthetic probes to elucidate the associations in these complexes from macromolecular to atomic level. Glucans, xyloglucans and galactomannans will serve as model soluble fibres, representative of real food systems, allowing us to determine their binding constants with nutritionally relevant micronutrients, such as monosaccharides, bile acids, and metals. Furthermore, we will examine supramolecular interactions between fibre strands to evaluate possible contribution of several fibre strands to the micronutrient associations. At the atomic level, we will use complementary spectroscopies to identify the functional groups and atoms involved in the bonds between fibres and the ligands. The proposal describes a unique approach to quantify binding of small molecules by dietary fibres, which can be translated to polysaccharide interactions with ligands in a broad range of biological systems and discipl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High Temperature Dynamics of Metals and the Earth’s Solid Inner Core' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Earths inner-core (IC) is 1220 km radius planet within the Earth, made of solid iron (Fe) crystallizing from the outer core (OC) as the Earth cools down. The IC affects our life at the surface; its growth provides a major source of energy for maintaining the Earths magnetic field. One may view the IC as a freezing ball of Fe floating at the center of the OC, but seismic exploration reveal structures of increasing complexity, raising fundamental questions on the history and internal dynamics of the IC.  Geophysical observations unearth the IC as it is today. Understanding the history of the IC and the effect of the IC on the global Earth dynamics, however, requires a reconstruction based on todays observations and knowledge of the physical properties of the IC Fe alloy, how they could affect IC dynamics, and their relation with present-day geophysical observables. There are significant knowledge gaps and outdated principles regarding the underlying physical properties of the IC Fe alloy. The IC temperature is close to melting, and the IC might even be partially molten. How does temperature affect of the mechanical properties of the IC Fe alloy? What is the effect of temperature and partial melting on seismic observables such as wave travel time and attenuation? This is poorly known and it hinders our interpretation capability of the ever-growing body of geophysical observations. In HotCores, advanced high pressure and/or high temperature experiments will be performed on Fe alloys and analogues. I propose to reenact key events of the history of the IC in the laboratory, as Fe crystallizes at the inner-outer-core boundary, as the IC grows and dynamically evolves to its present state, and as we see it today through the lenses of geophysical exploration. What is the stru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Competence Centre Microactuators' (CCMICRO) targeting Fifth Framework.

assistant: **Abstract**

CCMICRO will bring supplier and user communities together identifying and providing services in the field of microactuators providing services in design, R&D prototyping and brokerage in the field of microactuators, microoptics and of microsystems in RF applications. The partners will be the Central Microstructure Facility, UK, FhG-ISiT, Germany, and Sintef, NorwayObjectives:As part of the EUROPRACTICE Programme to support Microsystems Technology, a Competence Centre/Design House will be set up in the UK and Germany, and support centres in the UK, Germany and Norway.1. To continue the technical development of the Centre, specialising in but not limited to microactuators, microfluidics and MST processes.2. To ensure that appropriate industrial design tools are used to build up a standard design methodology.3. To offer design and consultancy expertise in more commercial processes.4. To set up R&D Support Centres in the UK, Germany and Norway.5. To assess and take appropriate action for the Centres to become financially independent of EU support.Work description:The work programme seeks to continue the preparatory work done by the partners under Europractice Support for microsystems technology in order to establish an industry orientated, financially independent Design House.The work programme will:1. Continue to offer brokerage microfabrication services to existing processes.2. Gain full familiarity with the new CAD design tools now becoming commercially available on the world market.3. Develop financial and business-orientated models of MST fabrication and product development, so that the road to financial independence can be established.4. Develop a business plan for a commercial Design House operation. This work programme will enable an increasing range of brokerage se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Future Improvement for Energy and Noise'.

assistant: **Objectives**

The FINE 1 project aims to reduce operational costs of railways by a reduction of energy use  and  noise related to rail traffic. The project results are expected to enable an increase of traffic in Europe and to enhance the attractiveness of railway in relation to other modes of transport. The project activities will support the innovation process within the S2R Technical Demonstrators (TDs) by providing methodology and know-how to enable development of low noise and low energy TDs. The project is fully in line with the EU objectives with eight technical work packages (WPs) addressing technologies to support these objectives. The reduction of energy use for rail vehicles is as addressed in WP 3 and WP4 and will indirectly lead to reduced green-house gas emissions, also with most rail transport powered with electricity. Further, reducing energy use will lower the life cycle cost and the costs of vehicle operation. The project also aims at development of practical methods for predicting noise and vibration performance on system level including both rolling stock, infrastructure and its environment. Prediction of interior vehicle noise is addressed in WP 7 and source modelling for interior and exterior noise in WP 8. With an accurate characterization of each contributing source, it will be possible to optimize cost benefit scenarios, as addressed in WP 6, as well as take exposure and comfort into account. Finally, the auralisation and visualisation techniques of traffic noise scenarios and the noise control techniques developed in WP 9, support the reduction of noise exposure for residents by efficient traffic planning and novel mitigation techniques. In summary, the expected FINE 1 advances of the state-of-the-art in noise modelling and control as well as in energy manag