RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing mediterranean regional transport' (1998-2002).

assistant: **Concept**

The countries of the Mediterranean area, North Africa and the Middle East, have an historic, cultural and natural patrimony constituting an extraordinary tourist attraction and, therefore, potential source of economic development. However, the inadequacy of some parts of the transport system is a stumbling block. The EMERET project aims at improving, in the direction of a greater sustainability and interoperability, the efficiency and effectiveness of the transport systems of the tourist areas of the Mediterranean countries. The objective will be pursued by means of studies that, on the basis of the results of European research projects of the IV Framework Programme, identify the principal problems and the possible solutions for the transport systems of the areas cited. Attention will be concentrated, in particular, on the transport system of the area of Bethlehem (Palestine), which will consitute the main project test site.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improve SMEs experience from Innovation Support Programmes' (DestinationUX) under Horizon 2020.

assistant: **Objectives**

DestinationUX aims to use the experience, the tools, the capacity and the partners’ knowledge in order to address a common innovation support challenge namely to increase the satisfaction and the participation of SMEs to existing and future innovation programmes through the creation of tailor-made toolbox regarding SMEs Experiences from Innovation Support Programmes. The toolbox/guide, entitled “Design Option Paper”, willhelp innovation agencies to :- map SMEs journey when participating in an innovation programme- identify the level of satisfaction per stage- find the gaps/ issues and improve the processIntermediary organizations offering support services on Innovation to SMEs are relevant actors in this process from two main points of view:1) they can help policy makers in the development and application of programmes,2) they can support SMEs to become more innovative.The Peer learning activity will serve to learn from the best and to share good and bad practices in increasing the satisfaction of innovationprogrammes to SMEs that will lead to better results and greater impact of the innovation programmes. In a few words the DOP will help innovation agencies to create better programmes for SMEs, with more impact, using less money and resources.


**Keywords:** innovation support schemes, SMEs, innovation agencies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Signal transduction in brain endothelial cells - an electrophysiological and fluorescene study in vitro' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The permeability of the blood-brain barrier has been shown to be influenced by several mediators, including hormones but also inflammatory mediators. Understanding the underlying mechanisms may contribute to the development of methods for blood-brain barrier opening, as a therapeutic strategy for some central nervous system disorders. The present project is for studying receptor-and channel-mediated changes in intracellular calcium, as well as activation or inhibition of membrane currents, in response to different mediators involved in normal physiology of brain endothelial cells and in inflammation. Links between each of these events and between them and functional properties of the barrier will be also investigated. The results will contribute to understand the cellular events involved in the regulation of endothelium permeability, and will help to explain the synergistic effects of chemical mediators in physiology and pathology. Training content (objective, benefit and expected impact) My first objective is to work on a project linking my two fields of interest (i.e. blood-brain barrier biology and signal transduction) and offering a medical aspect. My second one is to learn the advanced techniques developed by Dr Abbott's group (simultaneous calcium monitoring and patch clamp recording; flash photolysis for release of second messengers). And the third one is to improve my fluency in English. I think that the project will allow me to achieve all these objectives. Links with industry / industrial relevance (22) This project is relevant to the interests of the pharmaceutical industry, because of its implications for drug delivery to the brain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mechanics of compaction in the mouse pre-implantation embryo' in the context of a Seventh Framework call.

assistant: **Objectives**

Compaction is the earliest morphogenetic event in mouse embryonic development during which blastomeres increase the size of their cell-cell interfaces. This permits the establishment of apico-basal polarity and thereby the 1st fate specification of the blastomeres: trophectoderm derives from blastomeres with a large apical membrane at the cell-medium interface; whereas blastomeres composing the inner cell mass descend from cells with comparably larger basal cell-cell interfaces. Essential molecules regulating compaction were identified; among them are cell-cell adhesion and cytoskeletal components. However, the precise mechanism by which these molecules drive compaction is not yet understood. In particular, the forces and mechanical properties associated with adhesive and cytoskeletal components that are responsible for the embryo shape change remain uncharacterized. Combining biophysical methods and high-resolution microscopy, we aim to characterize cells mechanical properties and underlying molecules that control compaction. We will monitor, using micropipette aspiration techniques, the contractile and adhesive properties of mouse blastomeres during compaction. In addition, we will quantitatively track changes in cell shape and reorganization of key molecules. With this, we will build a spatio-temporal map of the mechanical properties during compaction. This interdisciplinary and quantitative approach will be key to build a comprehensive model of compaction in early mammalian development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Hexatic hydrodynamics: from driven soft matter to biological tissues'.

assistant: **Objectives**

How do hexatics flow? Forty years after Nelson’s and Halperin’s first prediction of the existence of this phase of two-dimensional matter, intermediate between crystalline solid and isotropic liquid, this seemingly elementary question is still unanswered. Whereas the delicate nature of hexatics could partially justify this oversight, recent findings in tissue mechanics have created the urgent demand to fill this gap, by providing this phase with unexpected biological relevance. Like two-dimensional crystals on the verge of melting, tissues are often neither ordered solids nor disordered liquids, but inhabit a continuum of intermediate states known as the epithelial-mesenchymal spectrum. This versatility lies at the heart of a myriad of processes that are instrumental for life, such as embryonic morphogenesis and wound healing, but also of life-threatening conditions, such as metastatic cancer. Understanding the physical origin of these mechanisms requires going beyond the current hydrodynamic theories of complex fluids and introducing a new theoretical paradigm, able to account for hexatic order and biomechanical activity. This multidisciplinary program aims to develop a systematic theory of hexatic hydrodynamics and use it to gain insight into the physical mechanisms underpinning the dynamics of tissues and the progression of metastatic cancer. The program will consist of three themes. First we will develop the necessary formalism to describe viscous flow in hexatics. Next, we will extend it to tissues and investigate the interplay between hexatic order, activity, topological defects and flow. Finally, we will use the new framework to explore the first three steps of the metastatic cascade: 1) the detachment of clusters of mesenchymal cells from the primary tumour; 2)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Biomolecular computers' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Autonomous programmable computing devices made of biological molecules hold the promise of interacting with the biological environment in future biological and medical applications. Our laboratory's long-term objective is to develop a 'Doctor in a cell': molecular-sized device that can roam the body, equipped with medical knowledge. It would diagnose a disease by analyzing the data available in its biochemical environment based on the encoded medical knowledge and treat it by releasing the appropriate drug molecule in situ. This kind of device might, in the future, be delivered to all cells in a specific tissue, organ or the whole organism, and cure or kill only those cells diagnosed with a disease. Our laboratory embarked on the attempt to design and build these molecular computing devices and lay the foundation for their future biomedical applications. Several important milestones have already been accomplished towards the realization of the  Doctor in a cell  vision. The subject of this proposal is a construction of autonomous biomolecular computers that could be delivered into a living cell, interact with endogenous biomolecules that are known to indicate diseases, logically analyze them, make a diagnostic decision and couple it to the production of an active biomolecule capable of influencing cell fate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fundamental Studies of the Sources, Properties and Environmental Behaviour of  Exhaust Nanoparticles from Road Vehicles""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Despite intensive abatement efforts, airborne particulate matter remains a major public health issue with costs across the European Union estimated at 600 billion euros in 2005.  Road traffic remains one of the major sources of particulate matter, and diesel emissions are by far the largest source of atmospheric nanoparticles in urban areas.  Semi-volatile organic compounds emitted largely in the condensed matter phase are a major component of diesel emissions, and as primary particles are advected from their road traffic source, the semi-volatile compounds vaporise and are oxidised, forming a greater mass of secondary organic aerosol (SOA).  However, the semi-volatile compounds are extremely poorly characterised as they are not resolved by traditional gas chromatographic methods, presenting an unresolved complex mixture (UCM).  For this reason, despite being a major precursor of SOA, such compounds are often poorly represented or completely omitted from atmospheric chemistry-transport models.  This proposal is concerned with applying new two dimensional gas chromatographic methods to characterisation of the UCM at a molecular level which will be followed by studies of the physico-chemical properties of representative components of the semi-volatile emissions.  The very abundant nucleation nanoparticle mode of diesel emissions is comprised almost entirely of semi-volatile organic material and hence these particles are progressively lost from the atmosphere by evaporation.  Until now, there has been insufficient knowledge of the properties of the semi-volatile components to model this behaviour reliably.  Such processes will be quantified through both controlled laboratory studies and carefully designed field measurements.  Numerical models on both a street canyon and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'High-resolution T1 mapping for the assessment of acute myocarditis'.

assistant: **Objectives**

Acute myocarditis is an important cause of heart failure and potentially lethal arrhythmias. Recently proposed therapeutic strategies for patients with acute myocarditis are based on a three-stage concept of the disease and require clear identification of the given stage of the disease. One of the principal features of magnetic resonance imaging (MRI) is its ability to visualize the magnetic properties of soft tissues, which are characteristic for a given tissue in a given state. Among these magnetic prope rties, the longitudinal or spin-lattice relaxation time (T1) is of particular interest. T1 is not only increased by the presence of water as seen in inflammatory oedema, but is also sensitive to the concentration of Gadolinium-based contrast medium, which can be applied to identify pathologic uptake in diseased tissue. T1 mapping is an MRI method which is able not only to visualize changes in T1, but also to quantify them. This is an important development when comparing data from different patients. In the course of his Marie Curie fellowship project, the proposer of this application, together with the host institution of the fellowship, has developed a novel technique (Modified Look-Locker Inversion Recovery, MOLLI), which for the first time allows accurat e high-resolution T1 mapping of the human heart on a clinical MR system. There is evidence that the novel MOLLI technique might be able to detect and quantify myocardial inflammation. In the proposed project, the MOLLI technique will be implemented and opt imized at the reintegration host institution, and the diagnostic value of MOLLI for the detection and monitoring of acute myocarditis will be investigated by performing serial MRI scans in patients with acute myocarditis and in control groups. The aim of t his pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetic control of the pathogenesis of diseases based on iron accumulation' in the context of a Sixth Framework call.

assistant: **Objectives**

Two main types of diseases based on iron accumulation will be studied:1) Chronic systemic iron over-load diseases.They comprise:i)HFE Haemochromatosis, which is one of the most frequent hereditary recessive diseases in Europe. It affects female/male subjects both in their quality of life and/or their vital prognosis. It should be emphasized that only a limited percentage (especially for females) of the individuals carrying the genetic hallmark predisposing to the disease (homozygosity for the C282Y mutation) will develop an overt disease, raising the issue of the involvement, beside acquired factors, of genetic factors accounting for this important global and gender phenotypic variability.ii) Non HFE Hereditary Iron Overload, such as Juvenile Haemochromatosis, Transferrin Receptor2 Haemochromatosis, or the Ferroportin Disease.2) The Anemia of Chronic Disease, which is the second most common form of anemia worldwide, source of important disability and related to local macrophagic iron accumulation. For both types of diseases, recent data have shed light on the key pathogenic role of hepcidin dysregulation.The aims of our project are to dissect the mechanisms, both at the genetic and molecular levels, accounting for the development of these body iron misdistributions and for their phenotypic variability. The fact that these two types of situations can be, on a pathophysiological viewpoint, considered as mirror" conditions constitute a major advantage for our integrated methodological approach which will rest upon animal and cellular models using innovative methodologies as well as upon the study of groups of highly selected patients. The expected improvement in our knowledge of the genetic control of the pathogenesis of these specific diseases should not only provide nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Dynamic belief updating in mice, rats, humans and models'.

assistant: **Innovation**

The environment is structured in time, allowing humans and animals to make predictions about the future and adjust behaviour. To this end, they perform ‘dynamic belief updating’ whereby beliefs about event probabilities are iteratively revised in light of new observations. However, this strategy is challenged by two properties of the world, namely stochasticity and volatility. These features imply that an unexpected observation might either simply reflect noise in the generative process or indicate that the process itself has covertly changed. While remedying to stochasticity requires to integrate over past observations so as to cancel out noise from the estimates, the countermeasure for volatility instead dictates to discard past observations so as to compute the most up-to-date estimates. How do humans and animals strike this difficult balance? In this interdisciplinary proposal, I offer to tackle this question using a unique combination of human cognitive neuroscience and rodent neurobiology, all guided by computational modelling. Authorities in these fields (Valentin Wyart, Ph.D. and Benjamin B. Scott, Ph.D.) will provide me with the missing skillset which, combined with my pre-existing expertise, will put me in an unprecedented position to unravel how mammalian brains factor in uncertainty during dynamic belief updating. Notably, I will test the idea that a sensory gain control mechanism gates the impact of novel observations onto past beliefs, and that this sensory gain is tuned by noradrenaline release from the locus coeruleus. The findings will inform neurocomputational theories of learning as well as contribute to a better understanding of cross-species similarities and differences, which is key for more fruitful translational research programs and better optim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Power generation from solar energy based on PEM fuel cell' (SOLARPEMFC) targeting Sixth Framework.

assistant: **Abstract**

The process is based on PEM fuel cell with specific catalysts and assisted by solar thermal energy to dissociate 2-propanol/acetone chemicals (a new coupling) at about 90ºC into hydrogen to feed it in the fuel cell to generate power. Dr. Chaurasia has don e preliminary work on it in Japan and so far experimentally obtained power density 0.259mW/cm2. This demonstrated feasibility and validated the concept of solar power generation based on fuel cell system. The purpose of this project is to improve the power density and efficiency for delivering usable power from the new solar thermal PEM fuel cell system.The specific objectives are as follows:1. To design and test a new solar thermal system based on PEM fuel cell for power generation from solar radiation.2. Study on PEM fuel cell in conjunction with solar thermal power assisted 2-propanol/acetone/hydrogen chemical reactions with specific catalysts and develop optimum configurations to maximize power density.3. Study of solar thermal 2-propanol dehydrogenation reactor to serve as generator of hydrogen for fuel cell.4. Study of different components in fabrication of PEM fuel cells for their performance.5. Design of prototype of solar thermal fuel cell and its testing for power generation from solar thermal energy.Dr. Chaurasia will use advanced chemical engineering techniques under the supervision of Prof. Kendall to develop specific types of catalysts, which increase the performance of the PEM fuel cells and 2-propanol reactor. The required specific catalysts (pure/composite) are to be synthesized for optimum catalytic configurations to maximize power density that will enable design of a practical solar thermal fuel cell to harvest chemical energy in addition to heat output. Dr. Chaurasia has a strong background on solar