RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effects of major histocompatibility complex immunogenetic profiles of wild hybrid and non-hybrid marmosets on their susceptibility to arbovirus infections' (HybridImmunogenetics) targeting Horizon 2020.

assistant: **Abstract**

Introductions of animal hybrids borne of exotic species and arboviruses represent costly anthropogenic environmental changes. These processes become intertwined if hybrids become arbovirus reservoirs. How does the admixed composition of hybrid immune genes, specifically Major Histocompatability (MHC) class I, affect the hybrid susceptibility to pathogenic disease?  A human hybridization study suggests that genetic introgression gives hybrids an immunological selective advantage, but such studies are few. Europe and Brazil have been impacted by arboviruse outbreaks from dengue, chikungunya, and West Nile. Because human travel intimately links these two regions, this close relationship augments the chance of arbovirus transmission between them. Hybrids of the primate Callithrix genus occur in many highly urbanized Brazilian regions of arbovirus outbreaks, and the hybrid parental species are carriers or susceptible to arboviruses infections. Here we propose to adopt emerging, portable sequencing technology to test the hypothesis that hybrids have a selective advantage to infectious disease susceptibility using the classical Callithrix MHC class I Caja-G/F segment. Further we will investigate diversity, natural selection, and genetic introgression at the genomic level and Caja-G/F segment in wild hybrid and non-hybrid Callithrix. By using this entire segment, this study powerfully harnesses the potential of the MHC region as a pillar of evolution studies and invigorates a paradigm shift in how such an important genomic region is studied. Additionally, this project will be the first to apply cutting-edge portable sequencing technology to study mammalian biodiversity, evolution, and wildlife health- a notion that democratizes the generation of genomic data. Finally, the resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Data-driven method based on a process mining approach for Automated Digital Twin generation, operations, and maintenance in circular value chains' (AUTO-TWIN).

assistant: **Concept**

The transition towards a Circular Economy is estimated to represent a $4.5 trillion global growth opportunity by 2030. Digital Twins availability is largely recognized as an accelerator and an enabler of Circular Economy in business and in production, but significant challenges are still standing in relation to its development within the present technological framework, the needed skill sets, and the implementation costs. AUTO-TWIN addresses the technological shortcoming and economic liability of the current system-engineering model by 1) introducing a breakthrough method for automated process-aware discovery towards autonomous Digital Twins generation, to support trustworthy business processes in circular economies; 2) adopting an (International Data Space) IDS-based common data space, to promote and facilitate the secure and seamless exchange of manufacturing/product/business data within value-networks in a circular-economy ecosystem; 3) integrating novel hardware technologies into the digital thread, to create smart Green Gateways, empowering companies to perform data and digital twin enabled green decisions, and to unleash their full potential for actual zero-waste Circular Economy and reduced dependency from raw materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Search for Milli-lenses to discriminate between dark matter models' (SMILE), addressing dissemination and exploitation.

assistant: **Impact**

One of the most compelling mysteries in both cosmology and particle physics is the nature of Dark Matter (DM). We propose to investigate this problem using strong gravitational lensing of active galaxies on the key but poorly-explored milliarcsecond scales. Gravitational lensed images with angular separation on milliarcsecond scales probe gravitational lens systems where the lens is a compact object with mass in the range 10^6 - 10^9 solar masses. This mass range is particularly critical for the widely accepted Lambda-CDM cosmological model, which predicts many more DM sub-halos, i.e., DM halos on sub-galactic scales (masses below ~ 10^11 solar masses), than currently observed. The most direct way to explore these small angular scales is through the high-resolution of radio Very Long Baseline Interferometry (VLBI). We propose to use VLBI data on a complete and large sample of active galaxies (~ 5000 sources) to search for gravitational lens systems on milliarcsecond scales. Given that no gravitational lenses on milliarsecond scales have yet been found, if any of the gravitational lens candidates that this search will produce is indeed confirmed as a true gravitational lens system, this would be a first and a major discovery. A null result instead will allow us to infer a new constraint on the abundance of compact objects in the mass range of interest, with over an order of magnitude better precision than in previous studies, and tighter than the number of 10^6 - 10^9 solar masses subhalos predicted by Lambda-CDM. Such a constraint could help discriminate between DM models that predict different numbers of sub-halos in this mass range. It could also help to constrain a possible contribution of primordial black holes as a DM component.


**Keywords:** gravitational lensin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention' in the context of a Seventh Framework call.

assistant: **Objectives**

Atherosclerosis and its most disabling sequelae, coronary artery disease (CAD) and stroke, are leading causes of death in Europe. Until now, preventive and therapeutic interventions for these diseases aim at ameliorating the effects of established cardiovascular risk factors. More recently, results of genome-wide association (GWA) studies added to our perception of mechanisms leading to atherosclerosis. At present, over 40 CAD and several genomic risk loci have been identified, the majority through efforts led by the applicants. Some genes at these loci work through known risk factors such as lipids and, in fact, are already established or evolving treatment targets. However, this is not true for the majority of risk variants, which implies that key pathways leading to atherosclerosis are yet to be exploited for therapeutic intervention. This EU network (CVgenes@target), which brings together an equal number of SME- and academic partners, will utilize genomic variants affecting atherosclerosis risk for identification of both underlying genes and affected pathways in order to identify, characterize, and validate novel therapeutically relevant targets for prevention and treatment of CAD and stroke. In programme 1 we will investigate molecular mechanisms at the genomic loci in order to further unravel causal genes, in programme 2 we will explore in vitro and in vivo whether the pathways disturbed by causal genes are suitable for therapeutic intervention, and in programme 3 we will establish assays and initiate high throughput screens to tackle therapeutically attractive targets. Our resources including large OMICs and state-of-the-art bioinformatics platforms as well as multiple, already established in vitro and in vivo models support the feasibility of the approach. In fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular atlas of the brain across the human lifespan' to be submitted under Horizon 2020.

assistant: **Abstract**

BRAINTIME brings together six laboratories that are international leaders in the field of single-cell genomics with the aim to apply their knowledge and expertise to understand the human brain. In BRAINTIME, we will: (1) Perform a comprehensive multi-omic analysis of the developing human midbrain and hindbrain to generate an atlas of key monoaminergic cell populations in healthy adulthood, ageing and neurodegenerative disease; (2) Embed our new cell type maps into 3D contexts and temporal developmental models by integrating new approaches for computational modelling, cell fate tracking, spatial analysis and capturing cell-cell interactions; (3) Establish single-cell genomics-empowered ex-vivo protocols and standardized ex-vivo/in-vivo projection algorithms to allow flexible model testing and perturbation analysis on midbrain and hindbrain tissues;  (4) Establish an effective and sustainable technological and analytical pipeline for the analysis of brain tissue at the single-cell level that can be used by the community to probe other brain regions or states and be extended to other human tissues. Achieving these objectives will significantly advance the Human Cell Atlas initiative by contributing major new datasets on human brain development and ageing, and ensure a key role for European labs in the global effort. Through the US partner (Ed Lein / Allen Institute), a crucial connection to the NIH BRAIN initiative will be ensured, including access to significant computational and atlasing resources. Through the SME partner (CartaNA), we gain access to cutting edge in-situ sequencing methods and support the fledgling European biotech industry in the single-cell field.


**Keywords:** single-cell RNA brain neuroscience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THE PINE WOOD NEMATODE:DEVELOPMENT OF A SAMPLING, EXTRACTION AND IDENTIFICATION METHOD' (PINESEIM).

assistant: **Concept**

Background :The pine wood nematode, Bursaphelenchus xylophilus, is an important quarantine pest infesting pine trees, thus causing wilt diseases. Serious damage to pine forests has been recorded in Japan and North America. To protect the European forests, directive 77/93/EEC imposes restriction on the importation of soft wood from N-America where this nematode and its vector are widespread.The objectives are : the development of methods for detection and identification of the pine wood nematode (PWN), Bursaphelenchus xylophilus, in timber and chips.Short description of the project :Current methods used in statutory inspection of imported timber need an improvement at three levels : sampling, extraction, identification. The objectives of this project are addressed to perfection of the methodologies practically applyable in the control procedure. Modification of sampling techniques and of methods for extraction/purification of nematode probes from wood is envisaged. For identifications and detectibility of pathogenic nematodes biochemical techniques are to be modified and improved. Finally, Plant Protection Services will be involved in testing the practicability of the new methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetoelectric 3D printing technology - the revolution of actuatable composites' (EVA).

assistant: **Concept**

The EVA project puts forward a radically new 3D printing technology that will revolutionize the nature of composites, transforming them from passive elements to responsive systems that can be instructed to execute tasks – on command. A technology that can program the mechanical, magnetic and electrical anisotropy of 3D printed structures in any direction, to fabricate systems that can be wirelessly actuated to elicit variable electrical responses during operation. Such unprecedented control over the properties and active functionalities of the printed systems will offer great advantages in multiple applications such as biotechnology (e.g. scaffolds to stimulate growth and differentiation of stem cells – 1st proof-of-principle), wastewater treatment (e.g. high-efficiency catalytic membrane to free wastewaters from persistent micropollutants – 2nd proof-of-principle), next-generation robotics, security and future data-storage technologies.EVA technology will empower engineers, researchers, and industrialists wanting to develop new concepts, materials, or functional devices to fine-tune matter at will with an affordable table-top solution. A technology enabling a new generation of multifunctional actuatable composites that can be printed and leveraged to develop radically new applications impacting multiple sectors of the economy.The potential of EVA project to achieve a proof-of-principle, and validate the scientific basis of the proposed breakthrough technology through this PATHFINDER call, is shown by the immediate endorsement from respected stakeholders, e.g. multinational corporations (Siemens) and disruptive SMEs (Nanoscribe & Transpharmation), policy makers, health professionals’ organisations, patients’ associations, and end-users (healthcare and water treatment fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Wetting and surface phenomena in type-i superconductors'.

assistant: **Concept**

The objective of this project is to extend the recent work of Indekeu et al. on the delocalization transition in type-I superconductors with surface enhancement. Particular issues we intend to address are: (1) Analysis of systems in which the surface-to-volume ratio is important reveals the H-T phase boundary for the onset of superconductivity is controlled by the size/shape characteristics of the sample. We shall extend this analysis, which has considered only superconducting/vacuum interfaces, to the more general case of interfaces with surface enhancement. (2) We shall apply the framework of line tension calculations to the case of type-I superconductors and analyse the singularities of the line tension at the first-order delocalization transitions found in these systems. (3) We intend to consider the possibility of nucleation and associated singularities related to the presence of surface spinodals in the case of type-I superconductors with surface enhancement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Influence of oxidants on cell fate determination by use of a GFP coupled redox sensor'.

assistant: **Innovation**

Reactive oxygen species are derivatives of aerobic metabolism. Their production is finely regulated to protect cells against severe and permanent damage to cellular components that could ultimately lead to programmed cell death. However at low levels, ROS act as second messagers in several signalling pathways leading to growth, differentiation, senescence or cell death. This dual function of ROS appears to be due to differences in their concentrations, their sub-cellular localization and the pulse-duration.  Using a newly developed fluorescent redox biosensor that allows dynamic live imaging of the intracellular glutathione redox state, I will study the role of endogenous oxidants in cell fate decision at the G1 checkpoint. I will follow the intracellular redox state of 3 primary cell types as they grow in culture, respond to mitogenic stimuli or differentiation factors and undergo senescence. Oxygen sensitivity of these processes will be also evaluated by modifying the oxygen culture conditions. Murine adult neural stem cells will serve as a model to study the balance between self-renewal and differentiation while mouse embryonic fibroblasts and human adult skin fibroblasts will be studied in terms of proliferative capacity versus senescence induction. Furthermore, we plan to generate transgenic mice constitutively expressing the redox sensor. This will allow us to compare endogenous redox levels in different tissues, over time and under pathological conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Phased array ultrasonic transducers for inspection of turbing'.

assistant: **Concept**

The Pharus project aims at developing a new set of ultrasonic transducers (1000 transducers in total) and associated electronics in a miniaturised package capable of operating in most oil wells. This new device with improved capabilities and reliability compared with state of the art technologies will be able to perform accurate inspection of tubing and piping in oilfield applications in harsh environment (175 deg. Celsius, 20 000 psi). A demonstrator will be produced and fully validated at laboratory level and in field. The technology developed will be compatible with industrial fabrication process for further production in volume.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Laser induced nanojet functionalization of two-dimensional materials for sensing and energy harvesting applications', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project will make an impact in important societal needs in the fields of energy harvesting and sensing for environmental, safety, and medical applications, which are relevant to the entire global population. The development of any of these high-tech areas is associated with the use of new materials. The scope of this proposal is to advance 2D materials by adding to them novel functionalities for improved energy-harvesting and sensing applications. Such 2D materials as graphene and transition metal dichalcogenides were selected for functionalization. The creation of nanopores or the attachment of chemically active compounds will significantly expand the capabilities of such materials, for example, it will enable the development of universal chemical sensors for the detection of volatile organic compounds. The project proposes to solve an important problem of functionalization, localized on nanoscale, which will allow minimizing the proposed devices.The disruptive technique to be used in this proposal for nanometer-precision patterning of 2D materials is based on one of the latest nanophotonics advancements, the photonic nanojets. It is possible to functionalize 2D materials by laser with spatial resolutions significantly lower than the diffraction limit, as light in a photonic nanojet can be concentrated into a volume that is one order of magnitude smaller. The project provides for a fairly simple and scalable technology. The low technological hazard of the method and invariance for materials are the basis for economic feasibility. New materials and devices arising from this project will be exploited by the industry, strengthening the EU economy and technological excellence in the fields of energy, electronic technology, health industry, security, environmental and i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BIOTREM - processing wheat bran into packaging products'.

assistant: **Objectives**

Project’s aim is to successfully commercialize BIOTREM technology – globally-unique, innovative and patented, sustainable method of processing by-products of the milling industry.Using modified servo-presses, the technology, allows moulding wheat-bran into designated forms. After processing the mouldings gain market value as biodegradable packaging. Their main application concerns disposable tableware or food-service take-away-containers.Biotrem packaging products are simultaneously bio-based, biodegradable within 30 days, use annually renewable agricultural side-products and are free of chemical additives. The above characteristics position Biotrem product line as a premium offer with environmental standards beyond its market counterparts.Degradable packaging, as market research show, is the fastest growing niche of the packaging industry – a business opportunity the project plans to exploit, as it provides products that meet a demand generated by both legislation (imposing decrease of packaging waste) and consumer trends (environmentally conscious attitude). Having concluded necessary R&D works and completing investments assembling the production line, the company currently strives to optimize the technology in operational conditions and to specify its short-medium and medium-long term business strategy.