RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Bioactive Implantable Polymers based on UreidoPyrimidinone'.

assistant: **Innovation**

BIP-UPy addresses the need for biomedical implants which can be easily fine-tuned in their properties in regards to bioactivity, biodegradability, and mechanical performance, and thereby be optimized for their targeted clinical application.This project will develop a library comprising of a selection of synthetic polymers and specific bioactivities which can be used to provide the required properties for a targeted biomedical implant.The polymeric materials that will be addressed are supramolecular UPy-modified polymers for uses in urologic implants and embolic implants, benefitting large population groups: bio-degradable meshes with improved in-situ tissue regeneration in pelvic floor repair and endovascular embolic implants with a reduced aneurysm recurrence risk.A mix-and-match approach will be used to bioactivate these supramolecular base materials. The supramolecular nature of the materials allows for mild processing conditions.Main objective is to develop a methodology for obtaining implantable polymers with specifically designed bioactivity for in-situ Tissue Engineering, in which the medical implant is obtained in one step by co-processing of the peptide molecules with the neat polymeric material.Key deliverables are protocols for processable biocompatible UPy-based polymers synthesis and manufacturing scale-up; protocols for UPy-based polymers bioactivity tailoring; procedures for processing the UPy-based polymers preserving the bioactivity efficiency; sterilisation protocols for bioactive medical implants; bioactive implants prototypes with tailored bioactivities; material and implant biocompatibility and bioactivity tests data; new predictive in-vitro tests and drafts of regulatory docs.BIP-UPy consortium comprises 9 partners from 5 European countries: 3 RTD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Arctic Geo-hazards, Geo-fluids and Climate Change' in the context of a Seventh Framework call.

assistant: **Objectives**

Recent studies indicate that water and methane stored in deep sediments might be abruptly mobilized by warming due to Climate Change.At the particularly climate-sensitive Arctic margin, sudden migration of such deep geo-fluids might cause submarine slope instability andlandslides, and might even result in a significant release of methane into the atmosphere. Submarine landslides threaten infrastructuresand can generate tsunamis. Today’s high interest in Arctic resources indicates an impending increase in industrial seafloor usage,especially near coastal areas. During past climate oscillations, protruding and retreating Arctic glaciers favored deposition of alternatingsandy and clayey layers on the slope. These sediments differ in porosity, density and water content because they experienced disparatedepositional history and mechanical consolidation, due to past waning and waxing of grounded glaciers. Ongoing temperature rise mayhelp to free geo-fluids that change current flow rates. Upward fluid migration in fractures and sediment layers with different properties willcause local high pore pressures that will decrease the shear strength of layers and potentially trigger submarine slides. Similar geologicalscenarios occurring during past interglacial periods are viable for large-scale submarine slides discovered in the region.This project aims at developing a detailed 3D numerical modeling of fluid flow at a type-example of an Arctic continental margin. We willdetermine the hydrogeological system, and numerically simulate scenarios of changing fluid flow rates, and how they affect pore pressureto study their potential effect on slope stability along the continental slope offshore Svalbard Archipelago (Norway). Modeling will be basedon available, unpublished, recently colle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Periods in Algebraic Geometry and Physics' (PAGAP), addressing dissemination and exploitation.

assistant: **Impact**

Periods are the integrals of algebraic differential forms over domains defined by polynomial inequalities, and are ubiquitous in mathematics and physics. One of the simplest classes of periods are given by multiple zeta values, which are the periods of moduli spaces M_{0,n} of curves of genus zero. They have recently undergone a huge revival of interest, and occur in number theory, the theory of mixed Tate motives, knot invariants, quantum groups, deformation quantization and many more branches of mathematics and physics.Remarkably, it has been observed experimentally that Feynman amplitudes in quantum field theories typically evaluate numerically to multiple zeta values and polylogarithms (which are the iterated integrals on M_{0,n}), and a huge amount of effort is presently devoted to computations of such amplitudes in order to provide predictions for particle collider experiments. A deeper understanding of the reason for the appearance of the same mathematical objects in algebraic geometry and physics is essential to streamline these computations, and ultimately tackle the outstanding problems in particle physics.The proposal has two parts: firstly to undertake a systematic study of the periods and iterated integrals on higher genus moduli spaces M_{g,n} and related varieties, and secondly to relate these fundamental mathematical objects to quantum field theories, bringing to bear modern techniques from algebraic geometry, Hodge theory, and motives to this emerging interdisciplinary area. Part of this would involve the implementation (with the assistance of future postdoc. team members) of an algorithm for the evaluation of Feynman diagrams which is due to the author and goes several orders beyond what has previously been possible, in order eventually to deduce concr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epilepsy Learning' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The last decades witnessed an extraordinary advancement in the development of biotechnologies applied to basic and clinical neurosciences and a tendency to the super-specialisation of human resources, increasing the cultural gap between basic-science and c linical operators. This precludes the development of a general vision of the mechanisms controlling brain function and may slow down the advancement of translational research aimed at understanding and curing brain diseases. As many as 40 million people in Europe have a history of seizures and 6 million currently have active epilepsy. Even though most patients respond to treatment, about 30-40% develop a chronic intractable epilepsy.Education plays a key role in increasing professional knowledge and in redu cing/preventing social exclusion of patients.To ensure standardized diagnostic work-up and care throughout Europe, and to improve understanding of the epileptogenetic process, a systematic educational programme should be implemented.A new generation of res earchers is needed that,irrespectively of their scientific background, will look at epilepsy with a novel perspective and a solid understanding of the potentials and the limits of technological advancements. Aim of the proposed series of events (3 Advanced Training Courses and a final Conference) is to promote interactions between basic neuroscientists and neurologists, by creating a common vocabulary through lectures and tutorial activities provided by a team of teachers sharing an integrate view of neuros cience,rooted in an outstanding expertise in epileptology.Eligible researchers will acquire managerial skills to plan, organise and develop research activities and to achieve exploitation of research products.The ultimate goal is to facilitate reciprocal t ran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In vivo and in vitro characterization of hptx3 - a new member of the acute phase" pentraxin gene family"' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

In vivo and in vitro characterization of hptx3: A new member of the 'acute phase' pentraxin gene family. ptx3 was recently cloned as an IL1-inducible gene in endothelial cells and belongs to the pentraxin gene family, including C-reactive Protein (CRP) and Serum Amyloid P Component (SAP). In spite of structural similarities (limited to the C-terminal half of the molecule) human ptx3 (hptx3) differs from classical pentraxins as for its genomic organisation, chromosomal localization and, more importantly, in vitro expression since it is not restricted to hepatocytes as for SAP and CRP and it is also evaluable in fibroblasts, monocytes and endothelial cells. In order to characterize the biological properties of the ptx3 protein, CHO cells have been transfected and a high producer recombinant clone has been selected. We plan to use the supernatant of this clone as a source of ptx3 to analyze the modulation of endothelial cell functions and the mitogenic activity of the protein. Furthermore, since ptx3 may represent the first identified member of a group of 'long' pentraxins (including the recently cloned apexin from guinea pig) we propose to identify new members of this 'long' pentraxin gene family.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innate immunity and vaccine development : role of soluble mediators (INVADERS)' in the context of a Fifth Framework call.

assistant: **Objectives**

The success of vaccines designed to fight infectious diseases is largely dependent upon knowing the effectors mechanisms responsible for protection. Moreover, as a consequence of the new technologies employing poorly immunogenic synthetic and recombinant antigens, the identification and characterisation of efficacious adjuvant has become crucial for the development of successful vaccination strategies. The project foresees the following objectives:1) To clarify the role of newly described regulatory patterns of cytokine production by macrophages in innate and adaptive immune responses;2) To identify natural factors regulating the development and life span of DC, which may be relevant for their in vivo generation and survival;3) To evaluate the impact of selected soluble mediators on the capacity of DC to bridge innate and adaptive immune responses;4) To develop animal models suitable for testing the adjuvant capacity of cytokines and of DC-based immunisation protocols. The overall results of the studies described in this project are expected to yield new and important information, relevant for the development of novel and more effective immune interventions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovation Relay Centre Slovakia' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The main objective of the IRC Slovakia is to support the trans-national technology transfer between Slovakia and the European Community, both inward and outward, dissemination and exploitation of the Community RTD results towards to Slovak industry, to sti mulate the capacity of the SMEs to adopt new technologies, to prepare support financial mechanisms, to support the innovation activities linked to FP6 and to contribute to the integration of the Slovak SMEs among the EU technology community, using the IRC Network and other proper means. IRC Slovakia project will be implemented by four experienced partners - BIC Bratislava, BIC Group, National Agency for Development of Small and Medium Enterprises and Slovak Chamber of Commerce and Industry. Based on the 7 years experience of work in the European Innovation Relay Centres Network the project partners will implement a set of instruments for enhancing the trans-national technology transfer based co-operation between the Slovak Republic and European Community. The proposed activities will identify the needs and the potentials of local industry and match them with technology offers and technology requests form the whole IRC network, inc. the Community RTD results. Within the matching process different instrument s as BBS, technology transfer days, joint IRC events will be used. Further activity of IRC Slovakia towards its clients will be the signposting of RTD and innovation services to respective national and European networks. IRC Slovakia will provide servi ces to the IRC network, especially it will supply the network with high quality technology offers and technology requests and will take an active part in multi - IRC actions. The proposed activities of IRC Slovakia will lead, beside other results, into 24 trans-nation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hydrogen isotopes in plant-derived organic compounds as new tool to identify changes in the carbon metabolism of plants and ecosystems during the anthropocene' (HYDROCARB) targeting Horizon 2020.

assistant: **Abstract**

HYDROCARB is motivated by the enormous potential that stable hydrogen isotope ratios (δ2H values) in plant compounds have as hydrological proxy, but in particular as new proxy for the carbon metabolism in plants. Current conceptual models suggest that δ2H values in plant organic compounds are composed of (i) hydrological and (ii) metabolic signals. The hydrological information that is contained in δ2H values of plant material is now well understood and is often applied in (paleo-) hydrological research. In contrast, the metabolic information that is contained in plant δ2H values is mostly unknown. Intriguing recent research suggests, however, that metabolic signals in the δ2H values of plant organic compounds reflect the balance of autotrophic and heterotrophic processes in plants. This suggests that exciting and previously unknown opportunities exist to exploit δ2H values in plant compounds for information on the carbohydrate metabolism of plants, which would be relevant for a broad range of biological and biogeochemical disciplines.The goal of HYDROCARB is to perform the experimental work that is now needed to identify the key biochemical and physiological processes that determine the metabolic information that is recorded in the δ2H values of plant organic compounds such as leaf wax lipids, lignin and cellulose. With this HYDROCARB will provide the basis for semi-mechanistic models that will allow (i) disentangling hydrological from metabolic signals in plant δ2H values and (ii) identifying the precise physiological processes with respect to a plants carbohydrate metabolism that can be deducted from the δ2H values of different plant compounds. If successful, HYDROCARB will establish with this research δ2H values in plant organic compounds as a powerful new proxy that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Innovative therapeutics for the prototype autoimmune disease, myasthenia gravis'.

assistant: **Concept**

We will develop novel, specific, therapeutics to treat the model autoimmune disease, myasthenia gravis, which is caused by antibodies to the muscle acetylcholine receptor (Ache). The therapeutics (to be tested extensively in vitro and in vivo experiments) will target different aspects of the immune response and involve(a) ex vivo immunoadsorption of the anti-Ache antibodies by immobilized polypeptide fragments of the Ache;(b) protection of the Ache and reduction of B cell activation by modified non-pathogenic engineered monoclonal anti-Ache antibodies;(c) selection of active subtractions of normal human lag for in vivo intravenous lag (Ivy) therapy; (d) induction of mussel tolerance by the use of recombinant Ache polypeptides;(e) peptide vaccination against a dominant T cell receptor;(f) peptide:MHC multimedia complexes to identify T cells ex vivo and tolerate them in vivo; (9) antilogous, Specific-specific, tolerogenic dendrite cells for in vivo use;(h) combinations of selected therapies; (I) for the more efficient therapies, we will study gene expression levels by micro array technology in order to explore their mechanisms of action, and to identify potential new drug targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In-Situ Monitoring of Electromagnetic Interference' (2021-2027).

assistant: **Innovation**

Only a few years ago, a mobile phone was exclusively used to make calls; today, it is a powerful, smart computer. Cars used to be purely mechanical, but now they're full of computing technology. Even medical equipment has evolved from basic instruments to high-tech systems. But for electronic engineers, it is a tough world, as more complex electronics are being positioned closer to each other, creating the conditions for electromagnetic interference (EMI). We simply cannot predict with any certainty what new technologies will emerge in the next decade. However, based on our experience, we do know that they will introduce new forms of EMI – whether radiated or conducted, quasi-continuous or transient –  amplifying the complexity of this issue. The iSENSE Doctoral Network on In-Situ Monitoring of Electromagnetic Interference has a clear mission: to train a new generation of experts who possess the skills and fundamental knowledge required to effectively address our intricate and ever-evolving electromagnetic environment to tackle the issue of EMI. Specific innovations to be expected are innovative EMI sensors and monitoring methodologies, early warning tools for detecting EMI, novel modelling and test strategies and, overall, a greater success in avoiding EMI issues. Based on the training in specific S/T skills, as well as soft and entrepreneurial skills, the iSENSE Doctoral Candidates will become highly employable scientists/engineers for the EU electronics sectors and other related industries, including automotive, medical equipment, power generation and distribution providers as well as for standardisation bodies, scientific institutions, and public organisations. Interdisciplinary training is assured with 9 universities and 2 research organizations as beneficiaries fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Understanding (dis)abilities: considerations on the body and the ethical consequences involved-Undicobatec'.

assistant: **Objectives**

“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less”. This famous quotation attributed to the scientist Maria Skłodowska-Curie emphasises the importance of «understanding» the realities of life and of understanding them «more and more», and we would add «better and better». In this sense, fear is contrary to science. It hinders its good development and its correct expansion. Regarding human relationships, fear is equally contrary to ethics, because it creates moral attitudes which are usually contrary to the values of respect, integration and inclusion promoted by the different Declarations and Charters of fundamental human rights (the WHO, Europe, Switzerland...). Discrimination, indifference and unfortunately maybe abuse are usually the results of fear and of the misunderstanding of a situation or a condition. Those are the barriers which disabled people have to face, particularly those who have several disabilities. That is the reason why the project «Understanding (dis)abilities», together with the different European policies and strategies implemented in favour of people with disability, wants to reflect on abilities rather than on disabilities. In order to do that, our reflection will start from the abilities linked to the body (the body understood as a global phenomenal reality) as they have been analysed by the different phenomenological ethical, or even under the approach of an interdisciplinary research, pedagogical tendencies of our time. All this with the purpose of arriving at the ethical consequences that such a vision implies in practice, that is to say, in the relationship, support, attention and care of people with disabilities”.


**Keywords:** Real-life experience, living body, Me