RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gut microbiota drug biotransformation as a tool to unravel the mechanisms of metabolic microbiota-host interactions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The variability of the human gut microbiome (entirety of microorganisms inhabiting the intestine) far exceeds human genome variability, and has been connected to various aspects of human health. Although microbiome differences are often linked to altered metabolism, the current view on metabolic interactions between the microbiota and the host remain mostly descriptive due to several limiting factors. First, most sequencing-based human microbiome studies rely on correlative analyses between microbiome composition and human phenotypes, depend on largely incomplete microbial genome annotations, and are not targeted to identify community-mediated functional traits. Second, many metabolites can be both of microbial and human origin, which makes it conceptually and methodologically challenging to disentangle metabolic microbiota-host interactions.To overcome these limitations, I propose a systematic bottom-up strategy to mechanistically study metabolic microbiota-host interactions by harnessing gut microbiotas capacity to biotransform (chemically modify) drug molecules. The large chemical diversity and exogenous origin makes medical drugs ideally suited for experimental in vitro and in vivo approaches to probe microbiota-host interactions in a controlled way. We will combine high-throughput culturing protocols, genetics, metabolomics measurements, genomics analyses, gnotobiotic mouse work, and computational modeling to connect interpersonal differences in microbiome composition to differences in metabolic functions of individuals gut microbiota, and ultimately link them to molecular host phenotypes. Generating these mechanistic insights and transformational resources is essential to understand the fundamental principles of the microbiota-host relationship. In addition, this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multimodal 3D Holographic tool and real-time Guidance System with point-of-care diagnostics for surgical planning and interventions on liver and pancreatic cancers' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Perioperative care is an intricate process that encompasses 1) preoperative evaluation, surgical planning and preparation; 2) intraoperative procedure; and 3) postoperative management. Perioperative care depends on clinical decision-making, a continuous process that involves many healthcare professionals (incl. radiologists, surgeons, anaesthesiologists, nurses, and others) who – based on the best available evidence, clinical experience, and the patient's individual circumstances – make informed decisions on the best course of action. Even though advancements in medical imaging modalities (CT, MRI, ultrasound) have greatly improved surgical outcomes, their interpretation towards deciding a specific course of action remains subjective. In addition, these modalities have several limitations when used alone (e.g., missed lesions; cannot provide a 3D visualization of key structures such as vessels), ultimately failing to provide a full picture of the patient’s anatomy that is shared and unambiguously understood by all in the assigned team. Due to these limitations, there are often suboptimal decisions that add to a cumulative risk of surgical complications in perioperative care. HoloSurge is a joint undertaking that brings European scientists and clinicians from high-tech companies, clinical centres, and research institutions in a consortium to deploy an innovative AI-based medical system that: i) enables automatic fusion and segmentation of state-of-the-art  imaging modalities for interactive 3D holographic visualization of patients’ organs; ii) provides real-time surgical navigation; and iii) allows real-time cell-level cancer diagnostics. The solution will provide surgical teams with an unmatched holistic view of the patient’s anatomy and pathology in real-time at point
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Program developing interdisciplinary research POtential for the STudies of BIOMolecular INteractions' to be submitted under Seventh Framework.

assistant: **Abstract**

National Centre for Biomolecular Research (NCBR), Masaryk University Brno in the Czech Republic has become one of the leading laboratories for structural biology in the Central Europe. The institute is very well equipped by modern laboratory equipment and instruments. It has established a competitive research program in structural biology through extramural funding from agencies such as the Wellcome Trust, Howard Hughes Medical Institute, European Molecular Biology Organization, 6th FP, Ministry of Education of the Czech Republic or Grant Agency of the Czech Republic. The institute has several teams pursuing both theoretical and experimental research that focuses on the structural characterization of  biomacromolecules. NCBR is now trying to refocus its research interest to biomolecular interactions study. That is essential for understanding how molecular machines operate in cells. To establish a competitive research program in biomolecular interactions has proven to be difficult in the Central Europe as the vast majority of know-how and expertise operate in “traditional” EU countries. Project POSTBIOMIN will strengthen our research potential through the scheme of support measures like recruitment of foreign experts, organization of international PhD courses and lectures given by top international scientists. Series of workshops, seminars, postdoctoral and expert inter-ships and visits will be organized. We suppose to reinforce our capacities related to transfer of technologies by hiring the West European specialist. This program will complement investments in research capacity co-financed through the EU cohesion policy programmes for 2007-2013, i.e., CEITEC - large project of Centro-European Institute of Technology focuses on biotechnologies and interdisciplinary medic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Formation of the First Stars' (STARLIGHT) under Seventh Framework.

assistant: **Objectives**

The appearance of the first stars marked a primary transition in cosmic history. Their light ended the so-called “dark ages”, and they played a key role in the metal enrichment and the reionization of the Universe, thereby shaping the galaxies we see today. Understanding high-redshift star formation is central to many areas of modern astrophysics. However, studying stellar birth in the early Universe is a relatively young field of science, and so still little is known about the origin and observablecharacteristics of the first stellar populations. Shedding light on the physical processes that governthe formation of stars in the early Universe requires a concerted, multi-facetted approach thatcombines a range of complementary expertise and innovative techniques. Using novel, high-resolution computer simulations we will (1) identify the physical phenomena that led to the formation of the first and second generations of stars in a systematic and quantitative way, (2) determine their mass distribution, which is the key parameter setting their lifetimes, luminosities, and chemical yields, (3) study the influence of the first stars on their surrounding environment, and (4) by doing so learn more about the subsequent cosmic evolution. We will set up a comprehensive theoretical and computational framework that enables us for the first time to make clear predictions and to compare our results with observational data from the high-redshift Universe as well as from the oldest stellar population in the Milky Way.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tomorrow's Elastic, Adaptive Mobility', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

TEAM aims at developing systems for participants in transportation networks, which help them to behave better – by explicitly taking into account the needs and constraints of other participants and the network itself. Focus will be placed upon decision-making in a time interval, above what is commonly associated with reactive safety (typically less than 5 seconds) and below long-term planning applications (typically 5 minutes and longer). In this interval human actors can employ modern technology to collaboratively devise socially optimal strategies. Thereby, we believe we will be able to reduce the social cost of traffic while increasing its efficiency and flexibility.<br/>The project is built around four basic themes:<br/>1. Basic technologies to realise collaborative mobility: We will advance communication technologies that underpin V2X by integrating LTE technologies, and by developing an automotive cloud-computing platform to support advanced and decentralised traffic management algorithms.<br/>2. Infrastructure-centric technologies and algorithms for elastic mobility: We will develop proactive infrastructure-centric algorithms and technologies to enable behavioural change in order to improve transportation networks in a way that takes into account real-time needs and constraints of all network users.<br/>3. Distributed technologies and algorithms to realise elastic mobility: We will develop proactive user-, community- and group-centric algorithms and technologies to achieve (and complement) the goals of theme 2. The vision is to use nomadic devices such as smart phones or on-board units to realise massively distributed collaborative control and optimisation concepts.<br/>4. Demonstration: The success of the project will be demonstrated via innovative leading-edge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Transgenic and knockout mice models of thyroid diseases.'.

assistant: **Innovation**

The present project proposes to combine the expertise and previous realizations of four European groups to develop animal models representative of thyroid diseases: goiter, thyroid cancer, congenital hypothyroidism. The thyroid is considered as representative of epithelial tissues in general. Its advantages as an object of study are the well described and easy methods for its physiological investigation, the availability of highly specific promoters and the consequent possibility of targeting the expression of any desired protein exclusively into the thyroid gland. This latter feature makes the thyroid gland an excellent model for gene therapy. Goiter is, with diabetes, the most prevalent endocrine disease. Although rarely dangerous, it is invalidating and, often requires surgery. Its impact is therefore important in terms of quality of living and social security costs. Thyroid tumors are the most prevalent endocrine tumors. In people over 50 years old, 50% of the thyroids have nodules, 4 to 5% of which contain a cancer. One of the major problems of modern endocrinology, exemplified by thyroid and prostate neoplasms, is the absence of fully reliable diagnostic tools to distinguish benign and potentially malignant lesions among the numerous nodules that modern technology now reveals. This leads to numerous avoidable surgical interventions with personal, social and financial consequences. Patients with anaplastic carcinoma die within a year after diagnosis. Congenital hypothyroidism is the most prevalent congenital disease. Lack of adequate correction immediately after birth, or even before birth, causes mental impairment. Its diagnosis after or even before birth is therefore of considerable importance. Because of the polygenic character of the diseases studied, realistic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pilot project for agriculture and agri-environment' (PAAGE) under Fourth Framework.

assistant: **Objectives**

The PAAGE proposal is submitted by MATRA MARCONI SPACE, JRC, NRSC, ITCF, SAINCO, INRA and representative user/partners involved in agri-business, agriculture and water management areas. PAAGE stands for Pilot project for Agriculture and AGri-Environment". Its major objective is to validate the value of a service based on superspectral imaBng remote sensing techniques. For that purpose, PAAGE includes airborne data acquisition over three sites (Spain, France and Great Britain). This proposal largely relies on previous activities carried-out by MATRA MARCONI SPACE, in particular the development and successful experimentation of superspectral imaging techniques and the assessment of the economic viability of a future space system using these techniques. The major targetted applications are: - diagnosis for precision farming to improve the cultivation processes, andto reduce the required amount of fertilisers, pestisides and waterressources, and in turn to mitigate the related environmental issues. - crop inventory to support the application of European policies - yield forecast which is of interest for actors in the agri-business and inthe frame of international or European negociations The proposed work content consists of six major sets of activities: - the first one is devoted to the analysis of the user needs, the selectionof the sites, the definition of the image acquisitions, the in-situmeasurements and the adaptations of the existing processing algorithms. - the second one consists of the preparation of the data acquisition campaignin terms of logistics (manpower, equipment, airborne instrument,...) and ofsetting-up the data processing tool, as a near real time data processing ismandatory for precision farming service experiment. - the third and the fourth ones incl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SMart and Interoperable THermal network system development' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The aim of SMITH innovation project is to design, develop, test under real life conditions and commercialise a novel productconsisting of a Smart and Interoperable Thermal Network for micro-industrial based on biomass sources.Unique Value Proposition of the product is based on: 1) provide industrial parks with the opportunity to reduce energy costsby promoting the cascade use and the highest efficient management of the heating infrastructure; 2) combine the centralisedmanagement of the system with an application for real time decision-making of the final users (including real timeconsumption, invoicing, decisions about the different temperature level options, head demand planning, etc); 3) clearlyforesee and plan before every product deployment the needed investment and infrastructure in order to assess the technicalfeasibility and profitability for both the consortium & customers; 4) design financial schemes based on energy servicecontracting that will avoid the industries to make investments for the new infrastructures; and, 5) reduce GHG emissions byusing renewable energies in industrial networks, most of them located close to urban areas.The SMITH strength vs natural gas source are: stable and lower price, better efficiency, more sustainable and flexible, highadaptation capacity to match consumption peaks vs users’ demand, better energy and temperatures management, highcontrol of industrial process, and stop and go more resourceful.The Feasibility Study will be focus on: a) assess the EU market needs in relation to the concrete product; b) select thecountries with the best conditions to start the commercialisation of the product, and draft the business strategy for eachcountry; c) profiling of customers in the target countries; d) obtain a direct feedback from consu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How Deforestation is Changing the Climate and Atmospheric Chemistry over Amazonia' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Amazon rainforest, renowned as the world's largest, plays a pivotal role in biodiversity, water cycles, atmospheric chemistry, and global climate. However, this vital ecosystem is progressively succumbing to vulnerabilities triggered by climate change and deforestation. Main drivers of deforestation are the expansion of pasture and agriculture. Over the past decade, these activities have surged, underscoring the pressing need for a scientific comprehension of the impacts of deforestation across Amazonia. To tackle this challenge, DECCA is adopting a multifaceted approach. First, through rigorous laboratory investigations, DECCA is scrutinizing the impacts of deforestation types on soil microbial community distribution, along with emissions of greenhouse gases (GHGs, carbon dioxide+methane+nitrous oxide) and reactive nitrogen (Nr, nitrous acid+nitrogen oxides+ammonia). By analyzing soil samples from different land use categories—ranging from pristine forests to areas converted to livestock and agricultural use—DECCA aims to quantify GHGs and Nr fluxes. This initiative encompasses an exploration of the influencing factors that drive GHGs and Nr emissions, ultimately enabling the establishment of emission parameters. Second, combined with a chemistry-transport model, DECCA quantifies the impact of deforestation on atmospheric chemistry and composition. This extends to understanding the formation of critical elements like ozone, aerosols, and cloud condensation nuclei. Third, a process-based biogeochemistry model is employed to estimate total GHG emissions for understanding GHG budgets and their climate implications. Moreover, DECCA incorporates predictions of land use evolution up to 2050, enabling supplementary model simulations for future deforestation scenarios. Thu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A rapid non-invasive on-chip miRNA-based Sputum Assay for early stage Lung Cancer Screening' (MI-SCAN) targeting Horizon 2020.

assistant: **Abstract**

Lung cancer is one of the leading causes of cancer mortality in the world accounting for an estimated 1.8 million deaths, 18.4% of the total in 2018.  Approximately 85% of lung cancers are classified as non-small cell lung cancer (NSCLC), a less aggressive form of tumor than small cell lung cancer (the remaining 15% of all lung cancers). The gold standard diagnostic methods for lung cancer patients include X-ray, low-dose CT and sputum cytology which are not efficient for early stage diagnosis of lung cancer. Lately, analysis of molecular markers has been proposed as a useful tool for cancer diagnosis in early stage. Molecular analysis of sputum is reported for identifying the cells bearing tumor-related genetic aberrations; therefore, it is specific and sensitive than cytological analysis. Furthermore, using non-invasive sputum sample have potential application for screening by molecular methods for regular health checking clinics.The proposed interdisciplinary methodology is to combine the Micro-RNA (miRNA) bioassay on microfluidic chip with Surface Enhanced Raman Scattering (SERS) spectroscopy. The goal of the project is to develop non-invasive detection of early stage (I, II) lung cancer using miRNA biomarker on-chip with multiplexed SERS technology. The overall system integrates a microfluidic device with gold particle linked with RNA probes that can capture target miRNA biomarkers for lung cancer cells. The SERS is used to generate a signal peaks when a positive test result occurs.Importantly, this biosensor platform will have several advantages over existing techniques. i) It is a label-free, amplification-free method for rapid miRNA detection. ii) The sensor platform can monitor multiple targets simultaneously. The project will eventually develop a portable and