RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Guidance of axonal pathfinding via nano-switches' (GAP) under Horizon Europe.

assistant: **Objectives**

Axon navigation is guided by spatial patterns of chemical and physical cues in the developing brain. After a damage, the pattern is lost. Axons do not have instructions to reach their target. Axon regeneration, if stimulated, occurs by chance. Unfortunately, current technologies do not allow us to control axon navigation decisions, and guided re-innervation is not possible in the central nervous system (CNS). The GAP project aims to fill this knowledge gap by modulating neuron mechanotransduction, in order to program axon pathfinding and to differentiate axon navigation decisions. Cells will be engineered to express magnetic nano-switches that can generate forces in specific nano/micro domains of specific neurons. Depending on the domain, the force triggers a different mechanotransduction pathway, resulting in axon elongation or axon retraction. The integration of the different outputs from different neurons can be used to re-shape the network.GAP will demonstrate the ability: i) to change navigation decisions (e.g., to guide axon elongation in the direction of a repelling cue or to disengage axon outgrowth mediated by an attracting cue); ii) to differentiate between different navigation decisions in a mixed neuronal population (e.g., excitatory versus inhibitory neurons); iii) to control axon navigation decisions in a living organism (e.g., promoting reinnervation of excitatory neurons in models of spinal cord injury). GAP would demonstrate the ability to control neural network remodeling which remains an unmet challenge for science.


**Keywords:** neuron, axon pathfinding, navigation decision, mechanotransduction, magnetic nanoparticle, nanomedicine,rational cell engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Defining the role of stromal cells in determining HCC patient response to immunotherapies at single-cell resolution' under Horizon Europe.

assistant: **Concept**

Hepatocellular carcinoma (HCC), remains a critical global health challenge, with limited treatment efficacy, particularly in advanced stages. The rising incidence of HCC is intricately linked to metabolic dysfunctions, such as metabolic-associated fatty liver disease (MAFLD) and its severe form, metabolic-associated steatohepatitis (MASH), highlighting an urgent need for enhanced precision oncology approaches. Despite recent advances, the lack of effective biomarkers and precision therapies for HCC underscores the complexity and heterogeneity of the disease.This proposal aims to address these gaps by integrating cutting-edge bioinformatics tools and genomic data to uncover novel mechanisms of HCC progression and treatment resistance. We will focus on three primary objectives: (1) Characterizing the immunosuppressive tumor microenvironment (TME) in HCC, emphasizing cell-type-specific regulatory programs and enhancer-promoter interactions that influence tumor progression and immune evasion. (2) Identifying specific cancer-associated fibroblast (CAF) subtypes and their role in patient response to immune-based combination therapies, particularly atezolizumab and bevacizumab. (3) Leveraging whole-genome sequencing (WGS) to pinpoint targetable mutations in regulatory regions, which can guide personalized treatment strategies and improve patient outcomes.By analyzing single-cell data and integrating it with whole-genome and RNA sequencing, this project aims to develop a comprehensive understanding of HCC's molecular underpinnings and its interaction with the TME. The expected outcomes include identifying new biomarkers for patient stratification, elucidating the role of CAFs in therapy response, and proposing actionable genomic targets for precision treatment. This research pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'High Q factOr MiniaturizEd low Mass (Accoustic) filters for highly DEmanding space applications'.

assistant: **Objectives**

The HOMEMADE project falls directly into the scope of the HORIZON EUROPE policy: “To reduce the dependence on critical technologies and capabilities from outside Europe for future space applications”. We target a fast growing market which integrates communication satellites in 5G networks that will reduce digital divide  by meeting latent demand for digital broadband. The project aims at developing a truly new Surface Acoustic Wave(SAW) filter technology not yet available to space industry. This innovation based on Piezo-On-Insulator (POI) wafers already produced for Smart phone industry is not accessible to space industry due to market size and its own high reliability specificities. Compared to existing technologies, POI-based SAW filters enable high integration, temperature stability, thermal management, low insertion loss and high rejection with various bandwidths in L- and S-band frequencies, replacing leaky waves on usual piezoelectric substrates by real guided waves on Silicon-based wafers. This project will deliver, as first pillar, POI-based SAW filters for space industry up to a TRL7 addressing all volume demands, in line with Geosynchronous Earth Orbiting satellites to Low Earth Orbiting satellite constellations. The supply chain for key items such as POI wafer supply, to front-end and back-end process is based in Europe. The high demand of innovation yielding reduced mass in satellites especially for new growing markets within a limited access time, has pushed to develop in HOMEMADE a second pillar that will deliver disruptive POI based SAW filters able to compete with bulky mechanical filters. The value chain includes European supplier of specific acoustic passive SOI-FREC as part of the SOITEC group with space integrator and technology supplier TAS, UCL an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of a two-approach plate system for the fast and simultaneous detection of MDR and XDR M. tuberculosis'.

assistant: **Innovation**

Tuberculosis (TB) continues being a leading cause of death due to a single infectious disease agent. The HIV/AIDS pandemic and the emergence of drug resistance are compounding factors that hinder the control of the disease. Associated with this problem is the emergence of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, defined as strains resistant to at least isoniazid and rifampicin, the most valuable drugs in the treatment of the disease. More recently, the appearance of extensively drug resistant (XDR) strains has been reported. These strains, in addition to being MDR, are also resistant to key second-line drugs. Patients, especially HIV patients, harbouring XDR strains have virtually no treatment options. New and improved methods for fast detection of drug resistance are urgently needed. This project will develop a twofold-approach system for the fast and simultaneous detection of MDR and XDR strains based on a rapid phenotypic assay and a genotypic test. Colorimetric methods, which have been previously validated by our group for first-line drug susceptibility testing, will be developed for key second-line drugs involved in XDRTB. Once set up, these methods will be further elaborated for direct application to sputum specimens. The molecular tool will be based on a modification of the novel technology named detection of immobilized amplified product in one phase system. This single step amplification method will be developed in a versatile microtitre well strip format for detection first of MDR and then of XDR strains. The tools will be then validated in different settings and prospectively evaluated in target populations. The project will contribute to the currently available armamentarium for rapid detection of drug resistant TB and will introduce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Solution-Based Engineering of Nanodimensional Phase-Change Materials and Memory Devices' to be submitted under Horizon 2020.

assistant: **Abstract**

Phase-change memory (PCM) is a recently-commercialized next-generation memory storage technology that provides a sustainable solution to exponentially-growing memory storage demands of modern society. It is based on resistively switched structural changes of memory cell upon local crystallization and melting phase transitions, resulting in amorphous or crystalline atomic structures with distinctly different “0” and “1” resistance states. PCM is faster and more durable than state-of-the-art non-volatile memory devices like silicon-based solid-state drives (SSD), and it can furthermore be scaled in all three dimensions. However, there are open challenges for PCM technology, such as large power consumption and high price of PCM devices, which stem from large dimensions of memory cells, complex fabrication process, and from use of material-inefficient sputtering and etching fabrication steps for the expensive PCM layer.This proposal addresses the open challenges and enables further development of PCM technology by applying solution-based engineering. Our goals are (i) to develop robust synthetic approaches for PCM materials, such as ternary tellurides and antimony-rich compositions, in the form of colloidal nanoparticles and molecular ink precursors; (ii) to thoroughly study how PCM properties change at the nanoscale as a function of size, thickness, and composition; and (iii) to employ these phase-change nanomaterials in solution-processed PCM arrays to build new, ultrasmall PCM configurations as well as multilayer PCM cells and to reduce their price and power consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Valorisation innovante des machefers d'incineration d'ordures menageres en corps de chaussee par traitement hydraulique' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Incineration with energy saving is one of the principal technique used to treat urban wastes. The number of municipal waste incinerators is strongly increasing in the European community. Therefore the production and the valorisation of the by-products generated by these plants is essential, in particular the valorisation of the urban waste slags. The principal objective of the project is to find innovating techniques for re-using the municipal solid waste slags treated with hydraulic binders and placed as base or subbase courses for road. These innovating applications will open new economic markets located near the production centers, and will increase the quantities treated. A broad cooperation between the various operators (producers, users, industrials performing slag treatment) is necessary in order to resolve all the technical issues; consequently the different parameters and analytical methods must be define during the feasibility study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Large Area Aerogel Catalyst' (LAACat) under Horizon 2020.

assistant: **Objectives**

Polymer electrolyte membrane fuel cells (PEMFCs) have attracted considerable worldwide attention because of their high energy conversion efficiency and low environmental impact. Their commercialization, however, is inhibited by the high loadings of the costly catalyst materials used at their cathodes, which is in turn related to their insufficient oxygen reduction activity and inadequate long-term stability. A promising solution that simultaneously addresses all these issues is the design of pure metallic, unsupported catalysts with extended surfaces. A particularly promising class of unsupported catalyst that has recently emerged is that of metallic aerogels, which consists of extended metal backbone nano-networks. This exclusive class of materials combines the unique properties of metals (such as good electrical and thermal conductivity, catalytic activity, and ductility/malleability) with the unique properties of common aerogels (high surface area, ultralow density, and high porosity). The fabrication of pure metallic aerogels with metal backbones by the direct sol-gel method was recently achieved for the first time by our group. These pure metallic aerogels have excellent performance potential in electrocatalytic applications.Successful upscaling of the straightforward aerogel preparation procedure will allow for subsequent testing of the material in market-ready PEMFCs with a 30 cm2 electrode area. The aim of this proof of concept project is therefore to create a prototype PEMFC using bimetallic aerogel electrocatalysts from large-scale synthesis (from technology readiness level 3 to 5) and design the optimal route-to-market strategy that would ensure swift adoption of our technology in an industrial setting. This prototype and the business case will be introduced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FUll Duplex Active Cancellation for wireless communication and co-exisTence' in the context of a Horizon 2020 call.

assistant: **Objectives**

The development of fifth-generation (5G) wireless networks is expected to provide technologies to support 1000x increase in data rates. To support the vision of hundreds of billions of connected devices after year 2020, many of the new technologies need to be developed. 5G is expected to utilize many more spectral bands, several of them at millimeter-wave frequencies, and much denser deployment of wireless infrastructure. As a result, co-existence between systems will be the key problem to be addressed at the physical level. In ""Full Duplex Active Cancellation for wireless communication and co-exisTence"" (FUDACT) we explore a set of new co-existence technologies culminating in a new radio transmission paradigm to improve spectrum efficiency. The FUDACT goal is to support two Europe 2020 flagship initiatives: Digital agenda for Europe by addressing some of the H2020 Future Internet challenges and Innovation Union by paving the way to innovation-friendly environment.FUDACT aims at a fundamental understanding of limitations of active self-cancellation techniques under conditions of simultaneous transmission and reception in close or overlapping frequency bands. The project's primary goal is to deliver a solution for a shared antenna system capable of cancelling at least a 1W transmitter (densely deployed small cells in wireless infrastructure) in the receive band, a great research challenge advancing the state of the art by at least 2 orders of magnitude. To accomplish these ambitious goals we will be pursuing the following closely related objectives: (1) Determine the technology limits of active cancellation of self-interference in wireless transceivers (2) Demonstrate an architecture capable of cancelling a +23dBm transmitter and a 0dBm of narrowband blocker (3) Invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Z-Coupled Full System for Attenuation of Vibrations' (2007-2013).

assistant: **Innovation**

The aim of this project is to find and demonstrate an optimal system for minimizing the transmission of vibrations generated in the Counter Rotating Open Rotor to the fuselage. For this purpose all kinds of conventional –passive, dynamic, active and semiactive- solutions for reduction of vibrations will be considered for optimization. The hard constraints of space, temperature and low frecuency could spoil most of the well-known conventional approaches. However, in order to overcome these difficulties and to increase the efficiency of these “well-known” solutions the use of a new technology of Impedance coupling will be also explored. This exclusive and new technology has become available as a result of the FP7-Space MAGDRIVE project and provides a non-contact, reliable mechanism able to multiply the efficacy of any conventional element (passive dampers, tuned vibration absorbers, active actuators or semiactive devices) reducing the overall required mass and volume of the devices. It can also integrate any of the above cited other conventional elements in a compact built-in design. Thanks to the non-contact characteristic and using appropriate common materials, the Z-Damper is expected to work at a temperature up to 700ºC providing a protective “heat barrier” for the conventional element in addition to the “multiplier effect” on the efficacy.MAG SOAR is a Small Technology-based Company incorporated as a spin-off of the above mentioned FP7-Space project MAGDRIVE. Its engineers have a recognised long expertise in Noise&vibrations projects –using all the existing known technologies, modelling, testing and instrumentation-. Additionally, MAG SOAR currently counts with aeronautical customers –i.e. Airbus Military- and is familiar with their procedures and standards. This, to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Competition, time pressure, public speaking and multitasking: The role of willingness and ability to cope with pressure in explaining individual differences and inequality in career outcomes' (CTSM), addressing dissemination and exploitation.

assistant: **Impact**

Inequalities in study choices and career outcomes between population groups, including Inequalities in study choices and career outcomes between population groups, including differences across gender and socioeconomic background, are highly persistent. This hints at unobserved barriers that limit diversity and prevent people from selecting the careers they would be most productive in. As a society, this may keep us from having the best people in the most important positions. Our limited understanding of what drives individual differences in educational choices and labor market success prevents us from identifying such barriers. My project builds on an ongoing effort to incorporate insights from personality psychology into economics. Past research indicates that personality traits (and other non-cognitive traits) have high potential for explaining career choices and outcomes. I will introduce new measures for four promising traits, willingness to compete, ability to cope with time pressure, public speaking aversion and ability to multitask. Time pressure, competition, public speaking and multitasking are hallmarks of high-level careers and individual ability to cope with these pressures is therefore a plausible determinant of career outcomes. These traits vary strongly across individuals, as evidenced by studies that document differences across gender, socio-economic background and educational achievement levels.  However, the potential of these traits for explaining individual differences in career choices is under-researched, in part because we do not yet know how to measure them properly in large samples. I will develop new measures for willingness to compete, ability to cope with time pressure, public speaking aversion and ability to multitask which can be implemente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The investigation and integration of WOMEN managed SMEs in FP5 and CRAFT research programmes' (WOMENCRAFT) under FP5.

assistant: **Objectives**

So far in Framework Programmes the number of visible women participants, particularly in the SME programmes, has been alarmingly low. This project will address both the visibility of existing women SMEs in the Framework Programme and encouragement of new women SMEs to exploit the opportunities of EC research programmes. The aims of this project are particularly relevant following the vote in the EC to support MEP Eryl McNally's communication on 'Women and Science - Mobilising Women to Enrich European Research'. The paper highlights the need to share experience among Member States on improving women's participation in science, and increasing the number of women engaged in Community research projects during the Fifth Framework Programme, which is exactly the goal of this project in relation to women in SMEs.