RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Establishing Blend Repair limit of blisks –from A perspective of Vibration amplificatiOn' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Efficient sustainment of the extremely expensive blisks in advanced aeroengines requires that damaged blades can be cost-effectively repaired by blending operations with high reliability. However, limited understanding of blending effects on the forced response of blisks challenges the rational determination of blend limits, i.e., the maximum allowable blend size, location and number in a damaged blisk. The underlying fundamental issue is whether or not the blends will exacerbate the intrinsic geometric mistuning such that the blisk is subject to excessive vibration level and fails from high cycle fatigue.The project BRAVO aims to develop a comprehensive vibration evaluation tool for blended blisks and establish the repair philosophy on blend limits. By employing the state-of-the-art 3D optical geometry scanning technology, geometry variances due to both blends and intrinsic blade geometric deviations can be effectively accounted for. Major scientific advances include:Novel deterministic methodologies of forced response analysis for blended blisks relying on the optically based as-measured model.Holistic vibration evaluation of blended blisks by comparing the as-measured-model-based simulations, modal tests, bench test under traveling wave excitation and spinning rig tests.Innovative probabilistic assessment for predictive evaluation of a population of possible blends and further determination of a tailored blend limit for a damaged blisk.A highly interdisciplinary collaboration will benefit both the ER with extensive experience in bladed disk dynamics, and the supervisor possessing top-level research capability in blade vibration testing. With deepened competence in both technical and transferable skills, the ER will reach a high level of professional maturity and scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unraveling the Supramolecular Architecture of Molecular Machineries in Adaptive Immunity'.

assistant: **Innovation**

To combat daily threats of pathogens and abnormal cells, the human organism features a sophisticated defense mechanism called the adaptive immune system. In broad terms, this intricate mechanism is triggered by specific peptide epitopes presented on molecules of the major histocompatibility complex class I (MHC I), which are scanned by cytotoxic T cells. Intracellular transport, loading, and cell-surface recognition of antigenic peptides on MHC I are orchestrated by machineries, the peptide-loading complex (PLC) and the T cell receptor (TCR) complex. The PLC is composed of multiple subunits, including the antigen translocation unit TAP, the MHC I heterodimer, and several chaperones ensuring that only stable peptide-MHC I molecules are released to the cell surface for decoding by TCR complexes. Ligand binding and the supramolecular organization of TCR complexes are translated into phosphorylation of conserved tyrosine-containing cytosolic sequence motifs that initiate downstream signaling cascades. Based on their incredible efficiency and selectivity, we hypothesize that the biogenesis of MHC I is highly processive and coupled via allosteric networking, and that antigen processing and recognition machineries are compartmentalized by a defined supramolecular organization. However, despite their fundamental importance, these architectural details of the PLC and the TCR, as well as the dynamic networking that is included in the quality control of the endoplasmic reticulum (ER) and receptor signaling processes, remain enigmatic due to their inherent dynamics, low abundance, and complexity.This ambitious proposal will contribute to a long-awaited holistic understanding of the machineries that shape the vertebrate adaptive immunity. The expected findings from this project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Neural circuit function in the retina of mice and humans' (CELLTYPESANDCIRCUITS).

assistant: **Concept**

The mammalian brain is assembled from thousands of neuronal cell types that are organized into distinct circuits to perform behaviourally relevant computations. To gain mechanistic insights about brain function and to treat specific diseases of the nervous system it is crucial to understand what these local circuits are computing and how they achieve these computations. By examining the structure and function of a few genetically identified and experimentally accessible neural circuits we plan to address fundamental questions about the functional architecture of neural circuits.  First, are cell types assigned to a unique functional circuit with a well-defined function or do they participate in multiple circuits (multitasking cell types), adjusting their role depending on the state of these circuits?  Second, does a neural circuit perform a single computation or depending on the information content of its inputs can it carry out radically different functions? Third, how, among the large number of other cell types, do the cells belonging to the same functional circuit connect together during development? We use the mouse retina as a model system to address these questions. Finally, we will study the structure and function of a specialised neural circuit in the human fovea that enables humans to read. We predict that our insights into the mechanism of multitasking, network switches and the development of selective connectivity will be instructive to study similar phenomena in other brain circuits. Knowledge of the structure and function of the human fovea will open up new opportunities to correlate human retinal function with human visual behaviour and our genetic technologies to study human foveal function will allow us and others to design better strategies for rest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Visual Scepticism. Towards an Aesthetic of Doubt' (2014-2020) under Horizon 2020.

assistant: **Objectives**

In early summer 2020, numerous monuments around the world were demolished after the death of George Floyd. The iconoclastic acts raise the pressing question of how this historical legacy should be dealt with. In a publication of the same name, Norbert Huse, a conservator of cultural heritage, spoke of ""uncomfortable monuments"" in this context. Since monuments of fascism and colonialism in particular also express the inhuman ideology of the regimes aesthetically, the frequently chosen solution of placing an information board next to the monument is not convincing, since in this way the effectiveness of this rhetoric in public space remains unchallenged. With the concept of ""visual scepticism"", the project proposes a different approach to these monuments. The monuments are to be aesthetically re-framed without completely erasing them from historical memory. The project therefore pursues three goals:Firstly, the concept of ""visual skepticism"" is to be explored to fundamentally examine whether and how visual media are capable of calling themselves into doubt. How do they succeed in generating insight with the help of inner contradictions. The thesis is that this form of knowledge production takes place on a purely visual level. It will be analysed how images can generate inner tensions and operate with dialogical structures that release knowledge. Secondly, monuments of colonialism will be examined in order to find out how this memory becomes effective for the public not only in terms of content but also aesthetically. This aesthetic appeal to the viewer's experience of space and his or her bodily senses will be analysed in detail. Thirdly, monuments that have been successfully re-framed will be discussed to show how artistic interventions have found aesthetic answers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Planning for energy efficient cities'.

assistant: **Objectives**

Today climate change causes serious problems to the societies worldwide and Europe starts to feel its consequences. At the same time European community is facing economical problems. One of the main producers of greenhouse gases is the non sustainable energy production and use. Therefore there is an urgent need to reduce energy use in most cost effective way.PLEEC will gather cities with innovative planning and ambitious energy saving goals. It will identify technology, citizens’ behaviors and structure driven efficiency potentials within urban planning and key city aspects. PLEEC will assess the status of energy efficiency and energy flows in the participating European middle size cities. It will improve understanding of basic conditions for energy efficiency in the cities through joint activities between city planners and researchers on technology, citizens’ behavior and structures. By finding the optimal mix of all energy efficiency measures the model for strategic sustainable planning will be created together with the action plans for implementation and management. The model and the action plans will address key aspects relevant for the whole city. They will be supported by the public authorities on the highest political levels. Analysis of time line, the costs and pay-back periods will be done based on different regulatory and market conditions of the participating cities. The model will guide the cities to find the most cost effective implementation of the EU SET-Plan goals to reduce energy use in EU by 20% till 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cleaner technologies in the leather industry' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The knowledge and technology to be transferred to the host institution CTIC relates to environmental technologies/methodologies for the leather industry. Know-how referring to the following technologies/concepts will be transferred to the host institution during the project: Mass-balances of leather production Environmental review/audit of tanneries Life Cycle Assessment Water savings Hair-saving unhearing High-fixation chrome tanning Furthermore, future co-operation possibilities between the host institution CTIC (Alcanena, Portugal and the Danish Technological Institute will be identified and a plan for this co-operation will be elaborated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Pressure Unloading LVAD: An Explantable and Cost-Effective Bridge to Recovery in Heart Failure'.

assistant: **Innovation**

The ability of the failing human heart to recover after mechanical unloading with left ventricular assist devices (LVADs) has been insufficiently exploited. To fill this void, we engineered the Pressure Unloading LVAD (PULVAD) system, designed to promote myocardial recovery. The overall objective of the proposed translational investigation is to evaluate the feasibility, safety and efficacy of this innovative pressure unloading approach as a bridge to recovery from heart failure. We will first investigate the effects of short-term PULVAD support on systemic hemodynamics and left ventricular mechanoenergetics in a large animal model of acute heart failure. We will then perform a pivotal randomized controlled study to investigate the safety and efficacy of long-term PULVAD support in promoting sustained cardiac recovery in a large animal model of chronic heart failure. If validated, this new technology has the potential to improve quality of life and ease the socioeconomic burden of advanced heart failure. In addition, histological, cellular and molecular analysis of paired myocardial biopsies obtained pre/post-PULVAD unloading will provide insight into mechanisms underlying cardiac reverse remodeling and myocardial recovery.


**Keywords:** mechanical circulatory support, left ventricular assist device, LVAD, cardiac unloading, heart failure, remodeling, reverse remodeling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The roadmap enabling spinal cord regeneration in mammals'.

assistant: **Concept**

It is widely documented that the adult mammalian central nervous system (CNS) does not regenerate. This failure results from the inhibitory scar environment and the decline of developmental growth programs. Overturning this dogma, the PI recently demonstrated that the spiny mouse (Acomys cahirinus) regenerates spontaneously the spinal cord, with robust functional recovery. Her current preliminary data support that an early switch occurs in the injured Acomys spinal cord, allowing scar reversion and activation of a regenerative program. In CORDheal, this exceptional non-model organism will be used to address the knowledge gap on the mechanisms enabling a mammal to regenerate the CNS. The pioneering nature of the PI’s data and her unique combined expertise in CNS regeneration and Acomys biology, places the PI at the forefront of the field. To find the roadmap enabling spinal cord regeneration in mammals, a single cell RNAseq/ATACseq atlas of the injured spinal cord of Acomys and Mus (regeneration-incompetent mouse) will allow discovering cell populations that enable activation of pathways supporting scar avoidance and promoting regeneration. The extent to which regeneration recapitulates development, and the possible birth of novel genes that may contribute to adaptive evolutionary innovation will be tested. As major instructive programs that allow regeneration of different Acomys tissues may be similar, comparative analyses amongst different regenerating Acomys organs will follow. Lastly, to determine when regenerative ability evolved in mammals, other members of the Deomyinae subfamily (to which Acomys belongs) will be assessed for regenerative properties. This will allow finding putative close divergent species, providing ideal conditions to narrow down differences bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cellulose: a key component essential for development and attachment of Streptomyces coelicolor?' (STREP-CELL) under Seventh Framework.

assistant: **Objectives**

Cellulose is the most abundant organic polymer in nature being a structural component of the cell wall of most plants. This highly insoluble polymer is degraded by filamentous fungi and actinomycetes, which secrete numerous enzymes tailored to fulfill this task. Streptomyces coelicolor is the best-studied representative of the actinomycetes, and a model organism for understanding prokaryotic development. It forms reproductive aerial hyphae after a period of assimilative growth. Unexpectedly, we identified a classical cellulose synthase gene whose inactivation critically impaired development on a wide range of media. Also, expression of this gene is strongly induced upon initiation of development indicating a key role for this enzyme during morphogenesis. Taken together, I propose that the cellulose synthase has a structural role in development by producing cellulose, which is incorporated in the cell walls of growing aerial hyphae. This could therefore represent the first example of bacterial cell walls that contain cellulose. Besides having an important role during formation of aerial hyphae, cellulose might have a second distinct function during attachment of Streptomyces hyphae to solid surfaces. Strong attachment involves the formation of an uncharacterized extracellular matrix of thin fibrillar structures associated with the adhering hyphae. This matrix strongly resembles that formed by various pathogenic bacteria, in which it was shown to consist of amyloid-like fibrils in association with cellulose. This proposal is aimed at elucidating the role of the cellulose synthase enzyme in morphogenesis and attachment of S. coelicolor. This research provides important new insights how structural modifications to bacterial cell walls affect microbial development. The host
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chromatic Algebraic Geometry' (AlgChrom), addressing dissemination and exploitation.

assistant: **Impact**

Stable homotopy theory provides a powerful framework for the study of algebra in the homotopy coherent setting. Its central notion is that of a spectrum, which is the homotopical generalization of an abelian group. Spectra appear naturally in a wide range of mathematical fields from number theory to differential topology, as they encode in a highly structured fashion various fundamental invariants, such as the algebraic K-theory groups of a ring and the cobordism classes of manifolds. The tools of stable homotopy theory have thus found remarkable applications in both algebra and topology, as well as in symplectic geometry, mathematical physics and more.The prevailing, and highly successful, paradigm in stable homotopy theory is the chromatic approach, which gives rise to an infinite family of intermediate characteristics interpolating between 0 and p, allowing one to implement local-to-global methods in homotopical settings. In this proposal, I shall describe several interrelated projects, with two unifying themes: The study of the intermediate characteristics using higher semiadditivity, and the import of ideas and tools from algebraic geometry to study both the local and global aspects of the chromatic approach.The preliminary results already provide significant advances on some of the central problems in stable homotopy theory, such as the chromatic redshift conjecture in algebraic K-theory, the construction of E-orientations, and the chromatic splitting conjecture. Furthermore, they facilitate partial computations of the Galois, Picard and Brauer groups in the intermediate characteristics.


**Keywords:** chromatic homotopy theory, stable homotopy theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Pan European Grid Advanced Simulation and state Estimation'.

assistant: **Concept**

PEGASE is a four year project dealing with the High and Extra High Voltage transmission and sub-transmission networks in Europe (designated as ETN) and implemented by a Consortium composed of 20 Partners including TSOs, expert companies and leading research centre’s in power system analysis and applied mathematics. Its overall objectives are to define the most appropriate state estimation, optimization and simulation frameworks, their performance and dataflow requirements to achieve an integrated security analysis and control of the ETN. The heart of the PEGASE project will involve advanced algorithmic, build prototypes of software and demonstrate the feasibility of real-time state estimation (SE), multi purpose constrained optimization (OPF) and time domain simulation of very large model representative of the ETN, taking into account its operation by multiple TSOs. Project R&D ambitions: The first ambition is to relieve all knowledge barriers to provide all TSOs with a synchronous display of the state of the ETN, very close to real time (typically each 5-10 seconds). The second ambition is to develop OPF programs determining realistic system operating points that include TSO operating rules but also optimal preventive or corrective actions, typically for real-time congestion management. The third ambition is to improve the existing state of the art technology in time simulation of very large system to permit: i/ off-line studies of the ETN including possibly interconnections with neighboring systems (i.e. Russia), ii/ dispatcher training simulation iii/ preventive security assessment and in on-line emergency conditions, faster than real-time simulation opening new perspectives for an anticipative control of the system. Project expected impacts: The availability of duly