RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Targeting Tau-induced cognitive decline with antisense oligonucleotides to synaptogyrin-3'.

assistant: **Objectives**

Tauopathies (that include Alzheimer’s disease) are characterized by hyperphosphorylation or mutations in the microtubuleassociated protein Tau. This reduces the affinity of Tau to bind microtubules and increases the levels of soluble detached Tau in neurons. Previous ERC-supported work from my lab showed that pathogenic Tau accumulates at pre-synaptic terminals and clusters synaptic vesicles in mouse and fly Tauopathy models and in Alzheimer patient brain samples. This pre-synaptic Tau reduces vesicle mobility and neurotransmitter release (Zhou et al., 2017). The interaction of Tau with synaptic vesicles occurs via the synaptic vesicle-associated protein Synaptogyrin-3. Lowering the levels of Synaptogyrin-3 blocks the ability of Tau to efficiently bind to synaptic vesicles (McInnes et al., 2018). Hence, Synaptogyrin-3 is a promising therapeutic target to tackle tauopathies. In this project I propose to use antisense oligonucleotides (ASOs) to reduce the levels of Synaptogyrin-3 in the brain of Tauopathy mouse models to rescue tau-induced pre-synaptic defects, including cognitive decline. ASO-technology has vastly improved over the past years and was recently approved to treat other degenerative disorders. My goal is to provide in vivo proof-of-concept that targeting Synaptogyrin-3 with an ASO in a therapeutic setting suppresses Tau-induced defects, including cognitive decline.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Support Infrastructure Models for Research Data Management'.

assistant: **Innovation**

The vision of SIM4RDM is to enable researchers to effectively utilise the emerging data infrastructures by ensuring that they have the knowledge, skills and support infrastructures necessary to adopt good research data management methodologies. SIM4RDM will achieve this by analysing existing funding programme interventions within member states and internationally, and producing models, evaluation frameworks and policy recommendations for both future national interventions as well as pan-European and International co-ordination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Metabolic functions of p53 in non-cancer pathologies' to be submitted under Seventh Framework.

assistant: **Abstract**

Extensive study of the p53 protein has resulted in a detailed understanding of its role in tumour suppression, information that is being used to develop small molecule modulators of p53 that are presently under evaluation for cancer therapy. However, it has recently become clear that p53 also plays roles in aspects of human health and disease extending beyond cancer - although most of these are poorly understood. We therefore propose to investigate some of these non-cancer functions of p53, with an emphasis on the role of p53 in the regulation of metabolism, extending to an analysis of whether p53 contributes to pathologies such as diabetes and obesity. This is a pioneering project that brings p53 research into new areas, yet builds on the solid platform of existing knowledge about the regulation and function of p53. State of the art genomic, proteomic, metabolomic and imaging analyses will be used to identify the roles of p53 in the response to metabolic stress caused by nutrient deficiency or excess, and investigate how these activities balance cell survival and cell death. Models will be developed to address how these functions of p53 relate to the control of metabolism and disease in vivo. Understanding how the cellular response to metabolic stress is controlled, and identifying a role for p53 in the regulation of metabolic homeostasis has enormous potential to influence the diagnosis and treatment of disease. The proposal will help to define the role of p53 in the development of diabetes and obesity, and lay the groundwork for the investigation of a role for p53 in other pathologies, such as neurodegenerative disease, cardiovascular disease and liver disease. These studies will therefore have far-reaching impact on some of the most prominent health threats in the d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamics of the Bacillus subtilis divisome' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Cell division is essential for the survival and reproduction of a bacterium. During vegetative growth in rod-shaped bacteria, such as Escherichia coli or Bacillus subtilis, cell division takes place at the precise cell centre by the recruitment of the so-called divisome that consists of at least seven conserved essential proteins. Current models of the assembly and dynamics of the divisome are solely based on genetically deduced dependence relationships. Furthermore, there is no information on the temporal order of arrival of divisome proteins and how this affects the assembly and dynamics of cell division. To date, a clear biochemical function has only been described for two of the conserved divisome proteins.The research described in this proposal is aimed at unravelling the functionalities of the divisome proteins by studying the assembly of the B. subtilis divisome in space and time. These fundamental questions will be addressed using state of the art techniques such as transcriptomics, proteomics and single-cell fluorescence imaging; all based on the unique B. subtilis spore germination system. Knowledge emerging from this research will improve our understanding of the essential process of cell division in B. subtilis and possibly other organisms. Insights from this research might provide new ways to target bacterial cell division and, subsequently, help in the design of innovative antibiotics.The host laboratory (Errington) has made major contributions to the fields of sporulation, chromosome segregation, and cell morphogenesis, and is considered as one of the worldwide leaders in the field of bacterial cell division. The applicant has a great deal of experience in studying gene-regulatory networks using single cell techniques but has limited expertise i n cell bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shedding light on three-dimensional gene regulation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The orchestration of precise gene expression patterns during differentiation and development is dependent on the cis-regulatory elements of the genome, which interact and communicate in three-dimensional (3D) chromatin structures. It is not well understood how these interactions are formed and influence gene expression. Our ability to identify the molecular mechanisms involved is hampered by a lack of tools that provide control over the function of regulatory proteins with high temporal precision and that measure 3D chromatin interactions at high resolution. In this project, we will overcome these hurdles by utilizing an ultra-fast optogenetic system that allows for efficient and reversible nuclear depletion of mammalian proteins upon blue light exposure. We will combine this approach with a range of high-resolution genomic tools to investigate the context-specific functions of transcription factors, co-activators, and architectural proteins throughout erythroid differentiation. Importantly, our set-up does not only allow for characterisation of acute protein depletion, but also enables us to map the molecular events triggered by restoration of regulatory proteins to the nucleus. This unique approach will therefore provide detailed insight into their molecular functions. Moreover, to get a more complete overview of the proteins involved in gene activation, we will implement a locus-specific proteomics approach that enables unbiased identification of the proteome of regulatory regions. This innovative integrated research program has strong potential to transform our understanding of the molecular mechanisms that shape the genome and drive gene activation during cellular differentiation. Furthermore, it will lead to the development of cutting-edge tools to analyse gene re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Inflammasome-induced IL-1 Secretion: Route, Mechanism, and Cell Fate'.

assistant: **Innovation**

Inflammasomes are intracellular danger-sensing protein complexes that are important for host protection. They initiate inflammation by controlling the activity of the proinflammatory cytokine interleukin-1β (IL-1β). Unlike most other cytokines, IL-1β is produced and retained in the cytoplasm in an inactive pro-form. Inflammasome-dependent maturation of proIL-1β is mediated by the common component of all inflammasomes, the protease caspase-1. Caspase-1 also controls the secretion of IL-1β, but the mechanism and route of secretion are unknown. We have recently demonstrated that the ability of caspase-1 to control IL-1β secretion is not dependent on its protease activity, but rather on a scaffold or adapter function of caspase-1. Furthermore, we and others could show that caspase-1 can control the secretion of non-substrates like IL-1α. These insights provide us with new and potentially revealing means to investigate the downstream effector functions of caspase-1, including the route and mechanism of IL-1 secretion. We will develop new tools to study the process of IL-1 secretion by microscopy and the novel mode-of-action of caspase-1 through the generation of transgenic models.Despite the important role of IL-1 in host defence against infection, dysregulated inflammasome activation and IL-1 production has a causal role in a number of acquired and hereditary auto-inflammatory conditions. These include particle-induced sterile inflammation (as is seen in gout and asbestosis), hereditary periodic fever syndromes, and metabolic diseases like diabetes and atherosclerosis. Currently, recombinant proteins that block the IL-1 receptor or deplete secreted IL-1 are used to treat IL-1-dependent diseases. These are costly treatments, and are also therapeutically cumbersome since they
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Data-Driven Bioeconomy' (DataBio) under Horizon 2020.

assistant: **Objectives**

The data intensive target sector selected for the DataBio project is the Data-Driven Bioeconomy, focusing in production of best possible raw materials from agriculture, forestry and fishery/aquaculture for the bioeconomy industry to produce food, energy and biomaterials taking into account also various responsibility and sustainability issues. DataBio proposes to deploy a state of the art, big data platform “on top of the existing partners’ infrastructure and solutions - the Big DATABIO Platform.The work will be continuous cooperation of experts from end user and technology provider companies, from bioeconomy and technology research institutes, and of other partners. In the pilots also associated partners and other stakeholders will be actively involved. The selected pilots and concepts will be transformed to pilot implementations utilizing co-innovative methods and tools where the bioeconomy sector end user experts and other stakeholders will give input to the user and sector domain understanding for the requirements specifications for ICT, Big Data and Earth Observation experts and for other solution providers in the consortium. Based on the preparation and requirement specifications work the pilots are implemented utilizing and selecting the best suitable market ready or almost market ready Big Data and Earth Observation methods, technologies, tools and services to be integrated to the common Big DATABIO Platform. During the pilots the close cooperation continues and feedback from the bioeconomy sector user companies will be utilized in the technical and methodological upgrades to pilot implementations. Based on the pilot results and the new solutions also new business opportunities are expected. In addition during the pilots the end user utilizers are participating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Training and research in the field of spectroscopic and computational charachterization of heterogeneous catalysts'.

assistant: **Objectives**

The Physical Chemistry Group, part of the Department of Inorganic, Physical, and Materials Science seeks candidates for Marie Curie fellowships at the post-graduate level, in the areas of surface science and catalyst characterization. The group is a recognized leader in the field surface studies using an interdisciplinary approach. Scientific activity is focused on two main research directions:a) the characterization of the structure and reactivity of active sites in zeolites and other solid catalysts by means of concurrent spectroscopic and theoretical methods, andb) the study of simple oxide surfaces with varying shape and defectivity, in order to bridge the gap between single crystal studies and studies on real catalysts. The techniques available are: IR and UV-Vis spectroscopies of probe molecules at surfaces under carefully controlled atmosphere and temperature, fluorescence spectroscopy, electron and AFM microscopies, adsorption studies, catalyst testing in gas-phase reactor, XANES, EXAFS and diffraction studies using synchrotron radiation (at the nearby Grenoble facility), abinitio and atomistic modeling of molecular and crystalline systems. The candidate fellow should be a post-graduate student with interest in one of the above mentioned research areas. Stays are available in Torino for periods of 3 to 12 months, upon mutual agreement of a research and training program between the hosting staff and the candidate's supervisor. The program may concern the study of a particular material, reaction or a methodological issue. The candidate will be able to take advantage of all courses held at the University of Torino (including language courses).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Multidimensional Analysis of Racism and Social Immobility at the Societal Level' to be submitted under Horizon Europe.

assistant: **Abstract**

Two of the most profound sources of exclusion in current-day societies are people’s ethnic and social origins. The main goal of MARIS is to examine the interlinked patterns of different dimensions of racism and intergenerational social immobility at the level of societies. Racism refers to the historically grown beliefs and practices that systematically disadvantage some ethno-racial groups. It has been conceptualized and measured by different research traditions, which each focuses on another aspect of racism. Intergenerational social immobility refers to the transmission of parents’ socioeconomic positions to those of their children. Also here, there are different traditions to examine these positions. What both racism and social mobility research have in common, is that there is little interdisciplinary integration of their dimensions. This is a serious gap, because each approach only covers a specific aspect and often yields different answers to basic research questions. Therefore, MARIS starts with a theoretical and empirical integration of four dimensions of racism at the macro-level: discriminatory behaviour, perceived discrimination, explicit attitudes and implicit bias. The macro-approach will consolidate the recent macro-social turn in racism research and opens a new paradigm of research questions. In the same vein, I also integrate four dimensions of social mobility: social class, status, income and education. In the next step, MARIS examines the interlinked patterns of racism and social mobility at the macro-level. While racism and immobility are intertwined in people’s lives and I can theoretically expect four possible combinations of both sources of exclusion, previous studies tend to examine them separately. By combining both, this project bridges two lon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Induction of pathogen resistance in fruit trees by transiently altering the flavonoid metabolism with specific enzyme inhibitors', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Apple and pear trees treated with the plant growth regulator prohexadione-ca are significantly less affected by fire blight (a bacterial disease) and by scab (caused by a fungus). Initial results indicate that prohexadione-ca, which is inactive as a bactericide or fungicide, transiently alters the sspectrum of endogenous flavonoids and related substances, thereby inducing natural resistance. The project aims at an in-depth elucidation of the under lying physiological, biochemical and molecular biological mechanisms. As a result, optimised methods for fire blight control, which are urgently needed particularly in pear -growing areas, and will become available. The disputed use of antibiotics to combat this disease will no longer be required. Likewise, the understanding of the new type of resistance mechanism will lead to new efficient, safe and environment friendly products for pathogen control in several further crop plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Memorializing Manzikert: Triumph, Loss and Making Sense of a Battle in the Twelfth-Century Mediterranean'.

assistant: **Concept**

MEMANZ investigates the construction of the memory of the battle of Manzikert in different literary discourses of the Medieval Mediterranean. The battle took place in the eleventh century between the sultan Alp Arslan of the Great Seljuks and emperor Romanos Diogenes of Byzantium. The capture of Romanos and the Byzantine defeat, the battle precipitated a chain of events that led to the civil war in Byzantium, a Turkic migration to Anatolia and the First Crusade.MEMANZ uses notions of “triumph”, “trauma” and “loss” to demonstrate how educated literati from Eastern Roman, Latin, Seljuk-Arabic and Armenian linguistic spheres constructed the memory of the battle for their own aims and means. A Byzantine princess Anna Komnene used Manzikert to rally Byzantine nobles around the flag of her family. A Crusader bishop William of Tyre used it to justify the onset of the Crusades. A Seljuk-Arabic intellectual Ibn al-Athir used  the battle to highlight the agenda of his Ayyubid rulers. Finally, a set of three Armenian historians depicted the battle as a meaningful event in the history of the Armenian community.The project reveals many unknown connections between different narratives about the battle. It demonstrates how a single event produced several cycles of interpretations in four different cultures, and how the later generations of educated people re-shaped the memory for their audiences. MEMANZ demonstrates the multipolarity of collective memory in the Medieval Mediterranean that is not limited to the dichotomy of “East” and “West”. The analysis of the construction of the battle allows better understanding of the nature of ideological dichotomies in the European Mediterranean. It opens a new path for the analysis of ongoing confrontations, some of which still deploy memories