RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'CHARM: From CO2 to Hydrocarbons in A circular bioelectRo- and photo-cheMical system'.

assistant: **Concept**

The transport sector is one of the largest and fastest growing energy consumers, and one of the most difficult sectors to decarbonize. Although there are projections of a rapid increase in low-power electric vehicles, there is still uncertainty in decarbonising high-power transport vehicles (ships and long-haul trucks). The European Union has committed to achieving at least 27% renewable energy share of gross energy consumption by 2030. A practical implementation is to produce advanced biofuels using bio-based technologies e.g. bio/electro/photo catalysis. These technologies can be used either alone or in a combined way to produce desired products e.g. hydrogen, methane, carboxylic acids, and hydrocarbons. Among these options, hydrocarbons are advantageous due to their versatile use and valorisation opportunities. However, current conversion technologies pose significant challenges: (1) whole cell fermentation is vulnerable to many factors (e.g. products inhibition), whist a wide range of by-products may be produced due to diverse pathways; and (2) traditional linear conversion processes have limited sustainability.To tackle these issues, I propose a two-year fellowship (CHARM) based on the Biocatalysis group led by Prof Hollmann in TU Delft. CHARM proposes a novel bio-based circular approach to enable production of light-weight hydrocarbons from both biomass and CO2 by integrating microbial fermentation, bioelectrochemical synthesis and bio-photocatalysis. CHARM will explore production of caproic acid as a platform chemical and its bio-photocatalytic conversion to value added C5 hydrocarbon (i.e. from CO2 to C5H12), whilst fulfilling CO2 recycle. Through this fellowship, I will reach a level of maturity on not only several scientific aspects but also on managerial and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transglutaminases: role in pathogenesis, diagnosis and therapy' (TRACKS).

assistant: **Concept**

TRACKS is a Research and Training Network focussed on the physiological and pathophysiological aspects in humans of a family of enzymes called transglutaminases (TGases). TGases are a widely distributed group of enzymes and have diverse functions in the body such as blood coagulation and wound healing, skin and hair barrier formation, extra-cellular matrix assembly, cell adhesion and intracellular signalling. TGases are drawing increasing interest because of their role in the onset and progression of specific pathologies such as celiac disease and associated autoimmunities, neurological disorders and tissue scarring and fibrosis. In celiac disease, a TG2 is the major autoantigen and is suspected to induce other associated autoimmunites such as diabetes and thyoiditis.The involvement of TGases in neurodegenerative diseases such as Alzheimer's disease, Huntington's disease and Parkinson disease and in tissue fibrosis and scarring like in diabetic nephropathy, is thought to result from a deregulation of enzyme activity leading to loss of tissue homeostasis and the cross-linking and post translational modification of a number of different proteins. Since TGases are thought to be at the centre of the pathogenesis of these different diseases they are considered an important target both for the development of new diagnostics and the development of new therapeutic agents.The aim of this network is to bring together key groups in Europe both in academic and industry who are actively working in the field of TGase and associated pathologies. By exchange of ideas, trainees, researchers, materials and the organisation of regular meetings, their objective is to gain a deeper understanding of TGases in these different diseases and in so doing develop new diagnostics and therapeutic ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From complex to non-archimedean geometry' (NONARCOMP).

assistant: **Concept**

Complex geometry is the study of manifolds that are defined over the complex numbers. Non-archimedean geometry is concerned with analytic spaces overfields endowed with a norm that satisfies the strong triangular inequality.The aim of this proposal is to explore the interactions between these seemingly different geometrieswith  special emphasis on analytic and dynamical problems.We specifically plan to develop pluripotential theory over non-archimedean fields. This includes the search  for analogs of the celebrated Yau's theorem. In a more local setting, we shall also look for possible applications of non-archimedean techniques to the ""Openness Conjecture"" on the structure of singularities of plurisubharmonic functions.A second axis of research concerns the problem of growth of degrees of iterates of complex rational maps in arbitrary dimensions. We especially aim at extending to arbitrary dimensions the successful non-archimedean techniques that are already available for surfaces.Finally we want to  investigate the geometry of parameter spaces of complex dynamical systemsacting on the Riemann sphere using  non-archimedean methods.  This requires the development of the  bifurcation theory of non-archimedean rational maps.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Single-Port Insulin Infusion for Improved Diabetes Management' (SPIDIMAN) under Seventh Framework.

assistant: **Objectives**

Existing therapeutic devices for diabetic patients suffer from bulky size, inaccurate measurements and the difficulties of handling two body interfaces. Suboptimal control of blood glucose levels in type 1 or type 2 diabetes mellitus patients results in periods of hypo- and hyperglycaemia leading to severe and life-threatening complications. Exploiting a novel glucose sensor technology, SPIDIMAN aims to improve glycaemic management for better quality of life and healthier aging. The consortium will develop a new coating technology to apply a glucose-sensitive fluorescent dye onto a standard insulin catheter and incorporate this integrated glucose sensor into a single-port artificial pancreas system. Advanced optical continuous glucose monitoring technology (smart tattoos) with improved sensor accuracy, faster response times, wider dynamic range and higher signal stability will advance diabetes management by reducing hypo- and hyperglycaemic episodes. Within SPIDIMAN, research-intensive European SMEs will develop an innovative artificial pancreas approach, and experienced participants will perform clinical validation in a European network of specialised diabetes centres. SPIDIMAN will thus pave the way for a single-port device that integrates improved glucose measurement and more accurate insulin delivery to provide better glycaemic management in patients with insulin-dependent diabetes. The new device is expected to be particularly suitable for patients in childhood and adolescence, who will form a special focus of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Contrast enhanced ultrasound imaging in the diagnosis and treatment of prostate cancer (contrast).' (CONTRAST) under Fifth Framework.

assistant: **Objectives**

Prostate cancer is the most common cancer in the elderly men. About 80% of all cases are diagnosed after the age of 65, and it has a major impact on the Sol. Accuracy of the current diagnostic tools available to detect prostate cancer is disappointing low. This concerted action approaches the improvement in diagnosis and treatment of prostate cancer by the coordination and dissemination of the currently performed research of the partners in the field of contrast enhanced ultrasound imaging. This action will for the first time bring together the best European groups working in this field. All partners already have made a substantial contribution to the clinical research in this field during the last years. This action will coordinate these contributions to reach a critical mass, and will disseminate the results to the professionals, the industry and the users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electromagnetic Platform for lightweight Integration/Installation of electrical systems in Composite Electrical Aircraft' under Horizon 2020.

assistant: **Concept**

This three-and-a-half year project is to release, validate and verify a unique computer environment (i.e. the EPICEA platform) assimilating a complete understanding of electromagnetic (EM) issues on Composite Electric Aircraft (CEA – i.e. aircraft with composite and electric technologies combined and operating at higher altitude/latitude). EM on CEA includes EM coupling, interconnects, and Cosmic Radiations (CR) on electrical systems together with new concepts of antennas designed to maintain performance in composite environment without modifying aircraft aerodynamics. In EPICEA, CR, as parts of the EM spectrum, are considered as EM environmental hazards such as lightning or HIRF (High Intensity Radiated Fields). The targeted computer platform will support a decision making process for selection of the best strategy for the integration of electrical systems. Starting at a TRL3, the consortium will demonstrate a TRL4 at the end of the project.The project will address numerous engineering issues, aiming at a significant reduction of energy consumption through more electrical aircraft and systems integration. If successful, it will create a more robust EM protection for electrical systems (i.e. lightweight, cost effective and safety compliant), a lighter and safer electrical system architecture for EM protected, less redundant, safety compliant, easy to maintain systems, a less drag on new systems of antennas while maintaining EM performance, and also will point to best possible health monitoring solutions. Used from the early design phase of electrical systems up to the architecture definition for installation and integration of electrical systems into CEA, the EPICEA outcome will limit the recourse to over conservative protection and unnecessary redundancy in integration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Methodology of safety in marine operations'.

assistant: **Objectives**

1. Gain a thorough understanding of the existing safety procedures and methodologies currently employed by Members States2. Gain an appreciation of whether systems employed by other transport modes could be employed in the marime sector3. Implement a common accident reporting methodology agreeable to all member states4. Develop a marine version of CHIRP5. Identify remedial tools %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Lightweight Vibration Absorption using Buckling Metamaterials' under Horizon Europe.

assistant: **Concept**

Vibrations cause unwanted noise and even failure in many areas, including vehicles such as spacecrafts, road vehicles and trains, sensitive optical or high-tech instruments and machinery. The market size for global vibration control systems was valued at 4.7 billion dollars in 2021 and is expected to expand to 8.1 billion dollars in 20302. This increase in demand is driven by a growing emphasis on the mechanical stability and balancing of industrial machines, which require ever growing precision and vehicles, which require ever growing safety.To counter these vibrations, many strategies have been developed. One of the easiest ways is to use viscoelastic materials, but there is typically an inherent trade-off: high dissipation entails low stiffness, whereas many applications typically require both high dissipation and high specific stiffness. Another approach is to use active vibration damping, but these systems typically add an additional layer of complexity and weight.Here, we propose to use Euler buckling as a functional mechanism to create vibrations absorbers. Buckling structures are simultaneously stiff and highly dissipative thanks to their high stiffness prior to buckling and highly nonlinear force and damping response during post-buckling. To this end, we will use flexible mechanical metamaterials made of metal and fibre-reinforced composites with tailored buckling and post-buckling. We will establish such metamaterials as a prime avenue to create lightweight structures that is orders of magnitude more dissipative than their linear viscoelastic counterparts. We will hence establish their potential as a competitive solution for lightweight structures combining high damping and high specific stiffness in high-tech and aerospace applications. In particular, our met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Efficient, portabLe And Secure orchesTration for reliable servICes' (ELASTIC).

assistant: **Concept**

The next generation of wireless communication networks, 6G, is set to revolutionize the scope and potential of networked services by offering ultra-high data rates, ultra-low latency, ultra-reliability, and energy efficiency. However, to fully realize the benefits of 6G, it is crucial to ensure efficient and effective orchestration of its broad range of services and resources.ELASTIC proposes a novel approach to 6G service orchestration that utilizes cutting-edge technologies, including WebAssembly (Wasm), Function-as-a-Service (FaaS), and edge Internet of Things (IoT) orchestration, to enable flexible and efficient serverless deployment of services and functions, dynamic scaling and optimization of service delivery, and collaborative processing of large datasets in a privacy-preserving manner.ELASTIC's approach addresses the critical issue of security in 6G orchestration by leveraging Confidential Computing with Trusted Execution Environments (TEEs), and by implementing security policies and service level agreements provided by verticals in edge cloud-native environments and enclaves. To support the development of this approach, ELASTIC will conduct extensive research on executable isolation, early detection of security vulnerabilities, comparative study of Kubernetes eBPF solutions for observability, and assessment of WASM security properties.ELASTIC will also develop a comprehensive infrastructure that includes an open-source framework and interfaces for cross-platform and portable drivers, low-latency, real-time monitoring of cluster-distributed eBPF/XDP and WASM for security issues, high-speed, secure communication algorithms, distributed state synchronization algorithms, and an observability framework for WebAssembly-based serverless/FaaS workloads in Kubernetes.T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microfluidic Tuning of Individual Nanoparticles to Understand and Improve Electrocatalysis' (MITICAT).

assistant: **Concept**

Transition metal based nanoparticles (NPs) are envisioned as viable alternatives to the scarce precious metal based catalysts used today for renewable energy conversion. Yet, probing their intrinsic activity to establish property-activity relations and so to smartly design superior catalysts, is impeded by two limitations of existing electrocatalytic techniques. First, the integral assessment of ensembles of non-identical NPs prohibits the identification of intrinsic activity differences. Second, the unknown effects of additives required analyzing the activity of often poorly conductive transition metal oxides, e.g. during the oxygen evolution reaction (OER), prohibit the access to quantitative data and comparable benchmarks. Very recently, we have proposed single NP electrochemistry to overcome both limitations. We demonstrated that the electrocatalytic OER response of individual CoFe2O4 NPs can be assessed in the absence of additives. However, we have not been able to extract property-activity relations, as NP characterization was limited to ex situ data. The groundbreaking strategy of this work is to combine intrinsic activity and physical property measurements of individual NPs. Physical characterization will comprise different online and ex situ methods to gain comprehensive property information. Numerical simulations will allow us to extract quantitative kinetic data from the electrochemical studies, allowing us to provide quantitative benchmarks of intrinsic catalyst performance. Cycling of NPs in a microfluidic platform will enable degradation studies and systematic modification “on the fly”. Moving towards application conditions, catalyst-support interactions will be studied by stepwise immobilization of catalysts on substrates. As a result of revealing intrins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European collaborative project on Targeted therapy in renal cell cancer: genetic and tumor-related biomarkers for response and toxicity' (EUROTARGET) under Seventh Framework.

assistant: **Objectives**

Each year more than 63,000 new cases of kidney cancer are diagnosed in the European Union. Approx. 50% of all patients have metastasized renal cell cancer (mRCC) at presentation or develop metastases during follow-up. 5-year relative survival of mRCC has been extremely poor: between 5 and 10%. In the past few years, so-called targeted therapies that suppress angiogenesis have changed the clinical practice for patients with mRCC dramatically. Both response and toxicity to these expensive drugs is, however, extremely variable. With an increasing number of compounds becoming available, choice of compounds and sequence is becoming extraordinary challenging. Classical patient and tumor characteristics appear to have poor predictive ability. The aim of this project is to identify germline genetic markers that predict response and toxicity (by the use of high-resolution whole genome SNP arrays in groups of hundreds of patients treated with different agents), identify expression and epigenetic markers in tumors that predict response (by comparing expression and methylome arrays and kinase profiles in frozen tumor tissue from groups of patients who do (N=30) and do not (N=30) respond to different agents), to integrate these data from different platforms by means of bioinformatics and to conduct focused functional studies on the results in order to improve understanding of the critical molecular and resistance pathways involved. A large European consortium that has recruited and will recruit large numbers of patients ensures that the new markers identified in a first discovery phase can be tested in a subsequent replication phase. We have the ambition to define new validated risk stratification criteria to be used in personalized patient management. These criteria allow predictio