RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Coordinated Research on Long-term Challenges in Information and Communication Sciences and Technologies'.

assistant: **Objectives**

CHIST-ERA is a Consortium of nine national organizations, each running a national programme supporting its research community in long term Information and communication science and technologies (ICST). The Partner funding programmes cover a large majority of the research in Europe and a significant fraction of the field worldwide.<br/>The focus of CHIST-ERA is long-term transformational research. Its principal objective is to reinforce the transnational collaboration between Member States in challenging multidisciplinary research in the area of Information communication science and technologies and to integrate the related national research communities in Europe through the funding of transnational research projects and accompanying community building actions.<br/>Even if the scientific scope of this Eranet is wide, the intention is to select from this area a number of focused, emergent themes of common interest, with the potential to lead to significant breakthroughs where there is not sufficient critical mass in a single country, and launch each year one or two calls on different selected topics.<br/>This goal is served by three operational objectives, namely setting the basis for effective and durable coordination and cooperation of the Partner agencies, identifying and sharing areas of common interest and new ambitious research topics with potentially high impact on future EU industrial research and competitiveness, launching common calls for proposals and their assessment.<br/>CHIST-ERA aims at overcoming the fragmentation of long term ICST research along national lines and thus create synergy to amplify the activities of the national agencies, to contribute decisively to the development of a concerted scientific policy throughout the ERA, and to fulfil the needs a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Protein Structure, Molecular Mechanisms and Human Genetic Disease: Beyond the Loss-of-function Paradigm' (PROT-STRUCT-DISEASE) targeting Horizon 2020.

assistant: **Abstract**

The ability to identify damaging genetic variants is central to the diagnosis, treatment and prevention of human disease. Computational phenotype predictors are widely used for prioritising likely pathogenic mutations, but their utility is limited by their accuracy. Conversely, experimental characterisation of variants is powerful but time consuming and difficult to perform on a large scale, limiting applicability in routine variant prioritisation. In this project, we will improve our ability to identify pathogenic variants through a combination of computational and experimental approaches. Fundamental to our strategy will be our consideration of alternate molecular mechanisms by which mutations can cause disease, in contrast to the current overwhelming focus on loss-of-function.First, we will use structural bioinformatics to investigate the different molecular mechanisms underlying pathogenic mutations, and learn how they are related to protein structure and phenotype. Next, we will perform deep mutational scanning (DMS) on at least 10 human disease genes, enabling us to measure fitness and elucidate molecular mechanisms for all possible single amino-acid substitutions. This will facilitate the direct identification of novel pathogenic variants, and allow us to evaluate the performance existing computational phenotype predictors. Finally, we will implement our own computational variant prioritisation pipeline and meta-predictor, using our new understanding of molecular mechanisms to integrate computational phenotype and stability predictors and DMS data with structural and other protein-level features. Crucially, we will demonstrate the utility of our approach in application to sequencing data from clinical and population cohort studies. Together, the knowledge we lear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced computing technology for innovative vibro-acoustic tools in engineering' (ACTIVATE) under Fourth Framework.

assistant: **Objectives**

The aim of the ACTIVATE project is to develop an advanced and innovative High-Performance Computing Vibro-Acoustic Platform (HPC-VAP), which will integrate state-of-the-art HPCN (High Performance Computing and Networking) concepts into existing well know vibro-acoustic codes.The new HPC-VAP will be based on the coupling between the structural code MSC/NASTRAN and the vibro-acoustic code RAYON-3D developed by STRACO/France, which will be parallelized in the frame of this project. RAYON-3D code is fully integrated in the CAD-CAE environment of SDRC/I-DEAS(TM) Master Series and incorporates advanced coupled numerical techniques based on Boundary and Finite Element Methods (BEM-FEM) for modelling vibro-acoustic radiation and transmission phenomena, including fluid-structure internal-external coupling.The ACTIVATE project will reinforce the leading position of European SME developers and vendors in the strategic market niche of vibro-acoustics, and will increase the competitiveness of European transportation industry by providing them with an advanced HPC Vibro-Acoustic Platform allowing them to drastically reduce the vibro-acoustic optimization costs, during the vehicle design phase. Additionally the vehicle comfort and the environmental quality will be enhanced.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'International workshop: community rangelands in southern africa: a sustainable future?' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The reconciliation of community socio-economic needs with biophysical sustainability of semi-arid, fragile rangelands is a major challenge. This issues the focus of an INCO-DC funded, interdisciplinary, multi-country project (ERBIC18CT970162). Significant progress has been made in site-based analysis, broader eco-economic modelling, and assessing the impact of governmental/EU interventions. A Regional/International Workshop is proposed in December 2000. The objectives will bea) to disseminate results,b) to facilitate cross fertilisation with related projects,c) to expand the dialogue with scientists and African policy-makers, andd) to consider future interventions and policies. The formal output will be publications of the papers presented, the discussions and recommendations . The results will include a critical evaluation of the modelling and policy analysis and advice for SADAC countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Pharmacogenomics Hub in a strengthened IMGGE'.

assistant: **Innovation**

Personalized medicine uses pharmacogenomics (PGX) to individualize therapy upon patients’ unique DNA profiles. With ~200,000 deaths/year in Europe due to adverse drug reactions, it has become an imperative to improve treatment. In Western Balkans (WB), individualization of therapy is done sporadically. IMGGE (Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia) is a pioneer in the PGX in WB. PharmGenHUB will strengthen IMGGE’s PGX R&I potential by exchanging knowledge between IMGGE and EU partnering institutions: University of Patras, Greece (UPAT), University of Ljubljana, Slovenia (UL), University of Trieste, Italy (UNITS). Through collaboration and knowledge sharing with 3 EU partners, IMGGE will become WB central place for PGX diagnostics and R&I, education and trainings, and translation of PGX knowledge into clinically applicable digital solutions. IMGGE’s research project, high-throughput DNA sequencing of WB populations, with support of UPAT and UL, will identify WB specific drug-PGX marker pairs and enable design of electronic tool for better decision-making in clinical practice, electronic PGX assistant for WB (ePGA-WB). iPSC model for validation of novel PGX markers relevant for Europe will be introduced at IMGGE with support of UNITS. IMGGE will renew, reinforce and establish new connections through networking with WB institutions. Project will be realized through short-term visits of IMGGE staff to EU partner institutions, staff exchanges, on-site trainings, experimental laboratory work. Outreach activities will include PGX days, WB conference and joint summer schools. To strengthen research management capacities and administrative skills of IMGGE staff, a research management unit will be established with assistance from U
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Standing at the Crossroads: Doubt in Early Modern Italy (1500-1560)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

This three-year research project aims to produce the first comprehensive social and cultural history of doubt and unbelief in Renaissance Italy. The project is timely since scholarly attention to the topic of unbelief and skepticism in Early Modern Europe is growing, as evidenced by recent publications and major research projects. In a period of dramatic cultural, political and religious change, traditional ideas and beliefs were shaken; and doubts on human reason and its powers arose. As a result, intellectual and religious authorities and long-standing truths began to be questioned by intellectuals and commoners alike, and anxiety over the powers and reach of human reason spread. A number of works were published in the vernacular that dealt with doubt and addressed a broad public. These works have never been coherently and systematically studied. This project will fill the void analysing such works with an ground-breaking interdisciplinary methodology. It will result in new comprehension of crucial aspects of European cultural identity such as the rise of the notion of freedom of conscience and the development of intellectual inquiry, and will revolutionise the traditional scholarly approach to a key moment in Italian and European civilisation.Marco Faini, an experienced researcher with international experience in Germany (Wolfenbüttel, Münster), in the UK (Cambridge), and at Villa I Tatti,  is confident that the development of this project will profoundly impact his career. Thanks to the training provided by Ca’ Foscari University in Venice and by the Faculty of History at Toronto University, Faini will acquire new skills and build fruitful relations with European and North-American institutions and scholars. The training, networks and publication of the project’s ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coordination by Evaluations and Valuations:Market Logic Inside and Outside the Economy' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This project studies evaluation and valuation as ways of coordinating actors and resources. Valuation is the ascribing of value to people, organizations, things and events given that there is no standard of value. Evaluation is judging according to an already existing value-standard. Valuation and evaluation are ways of ranking and thus ordering of  objects . Markets are examples of economic social formations in which valuations and evaluations are the foundation for the choices made. Valuation and evaluation are important means of coordination also outside of the economy, in competitions (e.g., sports), reviews (e.g., books), and auditing (e.g., of ethical conduct).This project is motivated by evaluation and valuation as increasingly influential ways of coordinating social life. Choices based on evaluation have gradually replaced networks and hierarchies as the preferred coordination form, but processes of valuation or evaluation are not well-understood. The overarching research question of this project is: how do processes of coordination based on valuations function? By understanding these processes can we analyze the consequences of coordinated by the means of evaluation in different spheres of life. It is also the foundation for policy suggestions.The proposed project uses theoretical insights about market elements in economics and sociology and on the relational sociological literature on social formations. Empirical sub-projects are designed to facilitate comparison, to establish validated conclusions and to promote theory development. This project opens up a new avenue of research of coordination based on valuation and evaluation. It will lead to the establishment a high quality research group located at the frontiers of social science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Machine state forecasting technology coupled with product quality control to unleash productivity for the manufacturing sector (EnCORE)' (EnCORE).

assistant: **Concept**

In the manufacturing sectors, the traditional planned maintenance approach is no longer viable, as it cannot cope with the ever-rising complexity of production systems. This pressing problem hurts industry’s profitability, and unplanned downtime costs industrial manufacturers €43 billion per year. This pressing problem has fuelled the growth of the predictive maintenance market. Currently, predictive maintenance solutions employ typical machine learning approaches based on monolithic rule-based predictions and require from the customer labelled data that correspond to defective machine states. This impedes the penetration of predictive maintenance in the industry. EnCORE is the fruit of 5 years of R&D to develop proprietary deep neural networks fit for predictive maintenance applications. Our solution uses best-in-class deep learning technology removing the overheads related with data preparation and enable the prediction of machine’s future condition using data that correspond to normal machine states. This is a game changing approach in the predictive maintenance industry. EnCORE is at TRL-6, with our software being validated at two different applications, (1) a compression moulding machine that produces plastic bottle enclosures/caps and (2) a cold forming machine that produces razor blades. Our target market will be the Food & Beverage and Consumer Goods industries targeting both OEMs of machinery and End-Users use such machinery. To take our product to the market, we will employ an hybrid business model using both direct sales and sales through industrial IoT platforms. EnCORE’s unique offering unlocks tremendous value for our customers; this will fuel the adoption of our solution by the industry. In the commercialisation period, we forecast cumulative profits of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of hevin in the neuroplasticity of stress-related disorders and addiction', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Matricellular proteins mediate interaction between cells and the extracellular matrix and are essential regulators of synaptic function and architecture. Recently, the two prototypical matricellular proteins SPARC and hevin have been implicated in depression-like behaviors, antidepressant response and resilience to stress. I found that hevin is induced by chronic social stress in the nucleus accumbens (NAc), a key brain reward region, only in resilient individuals. Importantly, its overexpression in susceptible mice could reverse social avoidance. This key observation, along with other evidence supporting a role for hevin in synaptogenesis and its presence at excitatory synapses, suggests that hevin is involved in the neuroplasticity underlying positive affect and motivation.My main objective is to define the role of hevin in the adatation to stress and drugs of abuse. I plan to combine my expertise in rodent behavior, neuroanatomy, pharmacology, molecular biology and viral-mediated gene transfer to first determine in which cell type hevin is induced in the NAc plays a role in resilience. I will manipulate hevin in selective cells using Cre transgenic mice and flox-STOP viruses in order to test whether it is required for resilience and antidepressant treatment in these cells. In the second aim, I will extend this anatomical and functional approach to study other emotionally-related behaviors, in particular in response to cocaine. I will also study the effect of hevin manipulation on dendritic spine morphology. Third, I will determine the mechanism controlling and regulating hevin in primary neuronal cultures. Last, I will identify hevin binding partners through co-immunoprecipitation and proteomics.This focus of research is particularly novel and promising, and is expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INNOVATIONS IN STOCHASTIC ANALYSIS AND APPLICATIONS with emphasis on STOCHASTIC CONTROL AND INFORMATION', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

For almost all kinds of dynamic systems modeling real processes in nature or society, most of the mathematical models we can formulate are - at best - inaccurate, and subject to random fluctuations and other types of ""noise"". Therefore it is important to be able to deal with such noisy models in a mathematically rigorous way. This rigorous theory is stochastic analysis. Theoretical progress in stochastic analysis will lead to new and improved applications in a wide range of fields.The main purpose of this proposal is to establish a research environment which enhances the creation of new ideas and methods in the research of stochastic analysis and its applications. The emphasis is more on innovation, new models and challenges in the research frontiers, rather than small variations and minor improvements of already established theories and results. We will concentrate on applications in finance and biology, but the theoretical results may as well apply to several other areas.Utilizing recent results and achievements by PI and a large group of distinguished coworkers, the natural extensions from the present knowledge is to concentrate on the mathematical theory of the interplay between stochastic analysis, stochastic control and information. More precisely, we have ambitions to make fundamental progress in the general theory of stochastic control of random systems and applications in finance and biology, and the explicit relation between the optimal performance and the amount of information available to the controller. Explicit examples of special interest include optimal control under partial or delayed information, and optimal control under inside or advanced information. A success of the present proposal will represent a substantial breakthrough, and in turn bring us