RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cellular mechanisms underlying formation of the fear memory trace in the mouse amygdala' to be submitted under Seventh Framework.

assistant: **Abstract**

Conditioned fear memory in response to an auditory stimulus serves as a prototype for studying the pathological emotional states as well as understanding the neural mechanisms of memory allocation, storage, retrieval and extinction. The conditioned fear memory in mice has been found to be allocated and stored within a subgroup of neurons in the amygdala, a critical region for expression of this type of memory. Expression levels of the transcription factor CREB (cyclic adenosine 3’-5’ monophospate response element –binding protein) has been shown to modulate allocation of memory to a specific group of neurons, constituting the memory trace, and neuronal excitability could play a role. Our goals in this proposal are, first, to investigate the synaptic properties in pairs of LA neurons before and after fear conditioning, and second, to delineate the neural mechanisms that allow a neuron to encode a specific memory and become part of the memory trace. In approaching our goals, we will conduct electrophysiological experiments in mice transfected with viral vectors that co-express CREB tagged with the green fluorescent protein (GFP) and the gene for channelrhodopsin2 (ChR2) allowing for specific activation of the transfected neurons. We will study the synaptic properties in pairs of transfected neurons by stimulating one neuron with a laser and performing whole-cell patch clamp recordings in another one. In addition, we will construct a network of amygdala neuron models based on experimental data which will allow us to simulate the emergence of plasticity changes observed in neurons that encode the same memory, and study the underlying biophysical mechanisms of these plasticity changes. The results from behavioral, electrophysiological and modeling experiments will give us in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mapping the impact of gut microbiota on brain and behaviour through the lens of GABA' (GutBrainGABA) targeting Horizon 2020.

assistant: **Abstract**

Human beings are over 99% genetically identical. It seems striking therefore, that 1% of this genetic difference accounts for the large extent of individual variations seen in human behaviour and brain function. One promising alternative source of individual differences is the resident bacteria in the gastrointestinal tract, which is 40-90% distinct between different individuals. Bacteria in the human gut outnumber human cells, and account for nearly 10 times as much DNA as that from human cells. Some gut bacteria have been shown to produce Gamma Amino Butyric Acid (GABA) and serotonin (5-HT), molecules that function as neurotransmitters in the human brain.  However, it is not known whether their production in the gut has any impact on behavioural and brain function. This project takes a biochemically informed approach to address this gap in knowledge through focussing on GABA, whose function as a neurotransmitter is well characterised, and which can be assayed directly or through proxy measures of brain and behaviour. The first work package of this project in human adults will investigate whether the population of gut bacteria capable of producing GABA can modulate brain levels of GABA (measured directly using Magnetic Resonance Spectroscopy), as well as performance in tasks that depend on GABA-ergic activity. The second work package will test the impact of ingesting bacteria known to produce GABA (packaged as a custom-made probiotic) over a period of four weeks, on the same brain and behavioural measures. Together, these studies will answer a fundamental question of whether the population of gut bacteria capable of producing GABA, as well as its modulation by probiotics, has any impact on the level GABA in the brain and its function. This interdisciplinary proposal br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PHOtonic integrated OCT-enhanced flow cytometry for canceR and cardiovascular diagnostics enabled by Extracellular VEsicles discRimination' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Imaging tools such as the Computed Tomography (CT) and the Magnetic Resonance Imaging (MRI) can offer diagnosis of the cancer and the cardiovascular disease (CVD), but not insight into the molecular mechanisms that promote their occurrence, progression and possible resistance to treatment. Information about these mechanisms is present however in the blood. Extracellular vesicles (EVs) are secreted into the blood, and can inform us about the state of their cells of origin, and by extension, about the presence and progression of diseases. Unfortunately, their detection is still imperfect due to the ultra-small size (50-200 nm) of most of them. PHOREVER will develop a disruptive multi-sensing platform that will enable for the first time the reliable detection of EVs with size down to 80 nm, the detection of EVs with specific biomarkers (proteins) on their surface, and the calculation of the corresponding EV concentrations in the blood. Its operation will be based on 3 sensing modalities: Flow-cytometry (FCM) with 4 wavelengths (405, 488, 633 and 785 nm) as the main modality for EV detection and size classification, dual-channel swept-source optical coherence tomography (SS-OCT) with 2.5 µm resolution for imaging of the sensing area and noise reduction of the FCM measurements, and fluorescence sensing at 488 nm for biomarker detection after staining. The key components will be the 2 photonic integrated circuits in TriPleX and the 3 microfluidic chips, which will be integrated as a compact point-of-care device. The medical impact can be ground-breaking. The first use case will be related to pancreatic cancer with focus on progression monitoring, metastasis risk assessment, and treatment efficacy evaluation. The second use case will be related to stroke with focus on its fast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interaction of two ultra-cold spin polarize he* atoms' (1994-1998).

assistant: **Innovation**

We propose to carry out the first scattering experiments with a beam of monochromatic neutral particles and an ultra-cold neutral target gas. As collision system we select spin-polarized triplet He-metastables, which interact via the molecular quintet-sigma potential. By performing the experiments over an energy range from 10 to 100 micro-eV we will be able for the first time to measure with spectroscopic precision the long-range van der Waals interaction in the region of 100 atomic units. These results will further yield evidence for the possibility of observing the so far unobserved quantum-phenomenon of Bose-Einstein condensation in this system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Demonstration of a Low No(x) Fuel-staged Combustor in a High Efficiency Gas Turbine Target Action F: Gas Power Generation' under Fifth Framework.

assistant: **Concept**

The overall objective of the project is to design, construct and test the concept of a fuel-staged combustor, to demonstrate a major enhancement of current lean premix technology. This is required as an enabling technology for high efficiency (>60%), flexible, CCGT to overcome the problems of combustion induced thermoacoustic pressure pulsations.The specific objectives of the project are to demonstrate:- Base load NOx emissions of below 10 ppmv firing natural gas and below 25 ppmv firing liquid fuels such as distillate oil at full engine operating conditions;- Thermoacoustic pressure pulsations of less than 0.3 % of total operating pressure over the full engine load rang;- Simplification of the engine commissioning procedure;- Elimination of fuel line purging;- Easy adjustment of the fuel-staged combustion system to different ambient conditions and engine operating requirements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ultra-soft microrobots for tumour penetration' in the context of a Horizon Europe call.

assistant: **Objectives**

SOFTINVADERS aims at advancing the technology readiness of the microrobots prototypes developed in the ERC-funded project CELLOIDS, paving the way to their future clinical translation. In CELLOIDS, we have developed the first ultra-soft microrobots and observed that they can move through gaps narrower than their size under magnetic actuation. The microrobots have a cell-like body consisting of a Giant Unilamellar Vesicle – an aqueous liquid interior enclosed by a nanometres-thin membrane made of a phospholipid bilayer. This allows them to deform substantially and even form thin protrusions, squeezing through narrow gaps and between obstacles. Such ultra-soft microrobots have the potential to traverse body tissues, mimicking the interstitial migration of leukocytes. SOFTINVADERS will challenge our microrobots with the daunting task of penetrating a solid tumour. This could open new opportunities for administering anti-cancer therapeutics in situ. The translation from research towards innovation will be achieved by addressing three main objectives: (i) enhancing the capabilities and magnetic actuation of our microrobots to make them suited to tumour infiltration; (ii) developing realistic in-vitro tumour models for the validation of microrobots; (iii) establishing a research collaboration with a clinical partner to guide the design of anti-cancer ultra-soft microrobots and define an innovation strategy. If successful, SOFTINVADERS will provide a preliminary validation of tumour infiltration by synthetic magnetic microrobots. This will represent the first innovation step towards the realisation of microrobots-enabled in-situ administration of anti-cancer therapies, potentially leading to improved therapeutic outcomes and better life quality for millions of patients worldwi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'TIME for Nano - Tools to Increase Mass Engagement for Nanotechnology' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The TIME for Nano Project aims at engaging the general public, with a special attention to young people, on benefits and risks related to nanoscale research, engineering and technology, through specific informal education products, namely the nano-kit and the organisation of a web contest each year that will be the basis for the realisation of events and debates for the public and collecting opinions and feedbacks from the participants. The products will use an inquiry-based learning approach, specifically developed in science centres/museums, where people understand by doing.  The nano-kit could contain e.g. small exhibits, nano-objects and materials, scripts for experiments and role/team game cards. It is a tool for stimulating the participation of youngsters in the nano-olympics and for engaging in debate scientists, stakeholders and the public in general. The web platform will be a resource centre and an attractor for the whole community of N&N communicators, through its contents (continuous addition of new information etc), its innovative tools ( web contest) and the artistic approach, the online feedback collection. A great added value of the project is that of “growing” a community of people engaged in N&N communication, through the realisation of training courses in each of the participating Science Centres (at national level) and by Ecsite (at European level) intended to reach a number of at least 450 multipliers (experts working in outreach and education efforts), carefully chosen among three main groups:  explainers in science centres and PhD students in science communication; teachers from primary and high schools.  The public participation to the web-contest is ensured by the organisation of many events in science centres of 9 countries each year: launch ev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A PHArmacogenomic study of Statins in the Elderly at risk for cardiovascular disease' to be submitted under Seventh Framework.

assistant: **Abstract**

Cardiovascular disease is the leading cause of death in industrialized countries. The prevention of cardiovascular disease is critically dependent on lipid lowering therapy, which includes the 3-hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins). Although statins are the most prescribed class of drugs worldwide, and therapy is generally associated with a reduction in risk for cardiovascular events by 20-30%, clinical response can be highly variable and adverse effects occur in a minority of patients. Recent research has provided evidence that in many cases, genetic variation contributes to this variable drug response. Research efforts should be made in analyzing the differences in genetic background to identify which genetic variation accounts for the variability in clinical response. Here we present a study that will establish in a large prospective randomized clinical trial with statin allocation which genetic variation is responsible for the variation in drug response. In 5804 participants of the PROspective Study of Pravastatin in the Elderly at risk (PROSPER) we will perform a genome-wide scan to assess the genetic variation responsible for variation in lowering low-density lipoprotein levels, in clinical outcome and for the occurrence of adverse effects. The unique character of the PROSPER study is that the study is randomized in three European countries, therefore all associations can be replicated in these countries. Positive associations will be confirmed in two comparable large clinical trials, the WOSCOPS and the CARE study. Cardiovascular pharmacogenomics will lead to improvements in the use of personalized therapy based on an individual’s genetic make-up. Non-responders or subjects who experience adverse effects will not be i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Is chronicity in collagen-induced arthritis associated with dominance of theth2 cell subset' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of the project is to test the hypothesis that, in chronic arthritis, a polarised Thl response drives articular disease and is followed by a protective Th2 response that mediates extra-articular disease. In order to do so, a chronic relapsing form of collagen-induced arthritis in mice will be developed that more closely resembles rheumatoid arthritis than the model induced with bovine type II collagen (CII), which is a self-limiting disease. DBA/1 mice will be immunised with mouse CII, which is known to induce chronic arthritis. Alternatively (and more conveniently), mice will be immunised with a DNA plasmid encoding mouse CII. Chronic relapsing disease will be described in detail: clinical course, extra-articular disease, joint histology, phenotype of synovial cells and cytokine production by the synovium and lymph nodes. In addition, Th 1 or Th2 responses will be manipulated with cytokines or antibodies, such as IL-4, IL-12 or anti-IL-12. A chronic murine model of arthritis will provide a highly valuable tool for studying pathogenesis and therapy of rheumatoid arthritis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Wireless Brain-Connect inteRfAce TO machineS: B-CRATOS' (B-CRATOS).

assistant: **Innovation**

Wireless Brain-Connect inteRfAce TO machineS: B-CRATOS:Merging novel wireless communication, neuroscience, bionics, Artificial Intelligence and sensing to create for the first time a battery-free high-speed wireless in-body communication platform for Brain-Machine-Body connectivity. Groundbreaking technological components - wireless two-way microwave fat intra-body and RF backscatter communication, battery-free powering technology, bio-inspired sensing, dexterous biomechatronic extremity- will be codesigned and a proof-of-concept, revolutionary untethered brain-machine interface will be created. This technology will have profound impact in the fields of neuroprosthetics (restoration of  missing biological functions such as vision, audition, movement, sensation, movement, cognition through the bypassing damaged circuits),  Brain-Computer Interfaces (brain plasticity through machine learning, gaming, virtual reality), and electroceuticals (modulation of organ function through neural circuits instead of pharmaceuticals), gaming (immersion), and Virtual Reality. B-CRATOS will overcome major challenges relating to power consumption, batteries, and data transmission bandwidth through breakthrough battery-free bidirectional wireless communication technology. The revolutionary signal bridge technology will impact healthcare, quality-of-life, and human learning and cognition. Key Enabling Technologies for this closed-loop functionality include ultra-low-power ASIC brain implants with read/write capability, battery-free in-body high-speed wireless communications systems, human-like artificial sensors and limbs.


**Keywords:** Neuroprosthetics, Brain-Machine Interface,  Fat-IBC,Electroceuticals, Brain-Computer Interface (BCI), Medical Device, Neural Control of Movement (MCM), Neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Camouflaging electronics in the brain with immobilized liquid coatings' to be submitted under Horizon 2020.

assistant: **Abstract**

In the UK alone, those suffering from brain disorders is approximately 45 million and associated healthcare costs exceed 130 billion euros per year. Neural electronics for recording and stimulating brain activity have become invaluable tools to study and treat disorders such as epilepsy, depression, and Parkinson’s. Currently used neural probes often fail in chronic evaluations (>1 year); the stiffness and chemistry of probes induce inflammation, neuronal death, and fibrous capsule formation. When examining a neural probe, the vast majority of the surface area is comprised of the encapsulation material; an insulating polymer that shields electronics from tissue. To date, most studies of implantable electronics have utilized only bare insulation as the tissue-interfacing material, yet in long-term studies, these insulation materials degrade and crack from the in vivo environment and expose the underlying electronics. Furthermore, adherence of proteins and cells to insulation promotes the immune response against the probe. Therefore, introducing an effective barrier between insulation and tissue is a highly promising approach for improving probe biocompatibility and performance. In this proposal, the approach is to use water-immiscible liquids anchored to the surface by a gel to shield neural probes from surrounding tissue. The proposed strategy of these immobilized liquid coatings (ILCs) is applicable to all implantable electronics, including those for other tissues and those based on various materials (silicon, metal, and organics). This proposal will focus solely on organic probes, which can be flexible and have recently been shown to improve biocompatibility by the reducing the mechanical mismatch between probe and brain tissue. Therefore, applying ILCs to organic neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Resistance artery remodeling, structure follows function?' (1998-2002).

assistant: **Concept**

The aim of the proposal is to determine the cellular and molecular mechanisms of the remodelling of resistance vessels, as seen in the development of many disease states, such as hypertension. The project is based on a novel in vitro experimental model of small artery remodelling.