RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Training innovative future leaders in research and development of materials and implants for the spine', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This proposal aims to develop Early-Stage Researchers into innovative European leaders in biomedical engineering, with a focus on spinal devices. Synergies will be drawn from the involved high-quality research centres in the interdisciplinary fields of materials science, mechanical engineering and biology, which will permit acquiring expertise in the development and preclinical testing of such devices, with a focus on meeting current and future societal challenges related to implant longevity and biocompatibility. The training programme has been put together in close collaboration with the relevant industry, SME’s as well as larger enterprise, ensuring adequate exposure to these environments, through e.g. secondments, as well as a knowledge base permitting a seamless transfer into industry and fostering innovation. An expert in industrial engineering and management will undertake co-ordination of the innovation-related training as well as consist of an independent career coach to the young researchers.The growing elderly, more active population puts higher demands on implants, which need to last longer and provide an adequate biological response throughout their lifetime. Current solutions for the spine suffer from a variety of issues, such as implant subsidence as well as potentially detrimental metal ion release and wear products. The current proposal aims to provide alternatives to these, by developing novel materials and implants for the spine, which provide i) non-detrimental wear products and reduced metal ion release and/or ii) enhanced osseointegration. Since many implant failures can be linked to inadequate loading, considerable effort will be spent on developing methods that simulate more closely adverse and individual biomechanical environments, as well as ad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A subcortical BCI to restore skilled movement' (SubcorticalBCI), addressing dissemination and exploitation.

assistant: **Impact**

Every year, half a million people become paralysed by a spinal cord injury. Assistive technologies, such as Brain-Computer Interfaces (BCIs), can improve their mobility, independence, and overall well-being. BCIs bypass a neurological injury by reading the user’s intent from their brain activity and using it to control a computer cursor or a robotic arm, or even to reanimate their own paralysed limbs. Despite these remarkable feats, BCIs still face challenges that prevent their widespread use.Here, I propose to address two of their main shortcomings: their unintuitive control that produces unskilled movements, and their instable performance that decays over time. The brain controls movement by coordinating the activity of many areas. Thus, unintuitive BCI control might be due to their reliance on the activity of a single cortical region (typically motor cortex) to decode the user’s intent. I will develop a new type of BCI that reads the activity of the striatum, a subcortical area that receives inputs from the entire cortex and has been shown to be critical for skilled movements. My hypothesis is that a BCI based on striatal activity will mimic the execution of a skilled movement. Using large-scale neural recording techniques and emerging computational techniques, I will identify striatal population dynamics and use them as input for the BCI, expecting to show that such an approach outperforms current BCIs. Next, I will address the instability problem. BCI instability is mainly caused by the inevitable changes in recorded neurons over long timescales. My host has recently developed a method that reveals the ‘true’ cortical dynamics underlying a given behaviour. I will adopt this method for the proposed BCI to stabilise its performance over long time periods.If successfu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'RAIL INFRASTRUCTURE CLEARANCE MANAGEMENT (INFRACLEAR)' under Sixth Framework.

assistant: **Concept**

The aim of INFRACLEAR is to allow optimum use of the infrastructure's track clearance" by means of an innovative approach for track gauging by using operational monitoring technology and thus to contribute to increase the capacity and safety of the infrastructure. Perfect knowledge of the "track clearance" is vital to guarantee that passengers and freight trains will be able to use the relevant infrastructure, and ensure optimum operation of this infrastructure by accepting larger "vehicles" and cargo. This would make it possible that the rail newly attracts passengers and freight which are currently running on the road. This is particularly important because gauges differ from one network to another and so only detailed knowledge of these networks will make it possible to define and draw up new routes compatible with the space required (using simulation tools), thereby improving rail's offer in competition with road. To obtain perfect knowledge of the "maximum loading gauge" we propose to develop, manufacture and validate (by test runs) an integrated inspection system (measurement device and associated data processing and modelling) capable of checking and recording the data associated with the vital functionality of the railway infrastructure. To be compatible with traffic constraints, the objective is to perform high-speed lines inspection (up to 140 km/h) with high performances in obstacles detection and measurement by running up and down on each track (security and safety aspects in particular after maintenance). The Project intends to achieve these objectives through a series of complementary tasks carried out at European level in order to avoid incompatible solutions with the Member States and ensure effective exploitation plans. The Project meets this requiremen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neural basis of auditory processing in young congenitally deaf subjects with cochlear implants' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal is to study the neural basis of auditory processing, as experienced by young congenitally deaf users with cochlear implant (CI). CI is a neuroprosthetic device that can evoke sensation of sound in deaf people by electrical stimulation of the auditory nerve. However, CI still produces very limited auditory sensations. Speech recognition in noise, multi-talker conversation, sound localization and music appreciation remain highly problematic for most of CI users. Current knowledge on auditory processing with CI is mostly based on studies with post-lingual CI users; these subjects used to have normal hearing, but had to adapt to electrical stimulation after they became deaf. It is not clear whether current problems in auditory processing by CI are due to the crude information provided by CI devices or because post-lingual subjects can not fully exploit all auditory information provided by CI devices. Therefore, our proposal aims at understanding auditory processing and its neural basis in specific subpopulation of young congenitally deaf subjects who received their cochlear implants within their first three years of life and have no normal hearing experience. In other words, we will collect and analyze data in subjects who developed their auditory system being exposed exclusively to electric stimulation. Our general hypothesis is that malleable brain plasticity during maturational phase, driven by solely electric stimulation, leads to enhanced use of available auditory CI cues and even to new forms of auditory processing. By comparing results of pre-lingual congenitally CI deaf users with those of post-lingually CI users, we will be able to disentangle neurobiological contributions from technological aspects of current CI devices to the auditory processing. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Optimised plant immune receptor pairs for improved disease resistance'.

assistant: **Concept**

CooPAIRation is an ambitious project that aims to harness the genetic diversity and evolutionary history of the TaPik wheat immune receptor pair to determine the molecular mechanisms underpinning paired receptor compatibility and guide the design of optimised immune receptor pairs for disease resistance. Bioengineering new resistance profiles in plant immune receptors offers a powerful solution for the timely deployment of new disease resistance traits in the field to fight off rapidly evolving plant pathogens that threaten food security. However, bioengineering plant immune receptor pairs often leads to suboptimal immune responses, likely due to receptor incompatibility caused by the editing process. To address this, the central hypothesis of CooPAIRation is that identifying the mechanisms underlying paired immune receptor compatibility in the context of natural and bioengineered alleles will guide optimisation efforts to enable the deployment and stacking of immune receptor alleles without detrimental effects for crop plants.To achieve our aim, we will combine phylogenetics, functional assays and structural biology to link variation in the immune response across different immune receptor pairs to specific molecular determinants of receptor compatibility and harness this information to design optimised receptor pairs for disease resistance. We will pursue the following objectives:1.Phylogenetics: Determine the variation in immune response triggered by coevolved and mismatched receptor pairs2.Mechanisms: Identify the molecular mechanisms underlying sensor-helper compatibility3.Biophysics: Define the biophysical properties of optimal and suboptimal sensor-helper combinations4.Resistance: Deliver optimised receptor pairs for disease resistanceAt the completion of this pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Drug Discovery and Target Identification Screening Platform for Age-Associated Neurodegenerative Disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Battling human neurodegenerative pathologies, and their pervasive societal impact, is a global multi-billion Euro enterprise. Ageing is universally associated with marked decrease of neuronal function and higher susceptibility to neurodegeneration. In human populations, this is manifested as an ever-increasing prevalence of devastating neurodegenerative conditions, including Alzheimer’s and Parkinson’s disease, stroke, several ataxias, and other types of dementia. Development of therapeutic interventions against such maladies is becoming a pressing priority. Drug discovery and drug target identification are two intimately linked facets of intervention strategies aimed at effectively combating human disorders. Genes linked to human diseases often function in evolutionary conserved pathways, readily dissected in simple model organisms. Such organisms provide attractive platforms for devising and streamlining efficient drug discovery and target identification methodologies. During the course of the ERC project NeuronAge, we developed a convenient and versatile platform for high-throughput chemical compound screening based on the nematode C. elegans (Nature 521: 525; Nature 490: 213). This innovative platform uniquely combines state-of-the-art microfluidics technologies for imaging and manipulation of neurons in vivo, with the experimental prowess of C. elegans, a highly malleable genetic model, which offers a precisely defined nervous system, two features that are not available in any other organism. We propose to: (1) bring this high-throughput compound screening system to pre-demonstration stage; (2) evaluate its dependability for drug target identification and drug discovery; (3) file US and European patent applications for IPR protection; and (4) identify potential com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanistic Studies on Carbon Monoxide (CO)-Induced Modulation of Mitochondrial Function in Neuroinflammation' (CO) targeting Seventh Framework.

assistant: **Abstract**

Neuroinflammation plays a crucial role in the development and progression of neurodegenerative diseases such as Alzheimer’s or ischemic stroke. The inflammatory response is coordinated by resident cells (microglia) that upon activation produce pro-inflammatory mediators including cytokines, chemokines and reactive oxygen species. Identification of small molecules that alleviate microglia inflammation is therefore pivotal in uncovering feasible therapeutic approaches to treat brain disorders. Emerging evidence indicates that carbon monoxide (CO), which is endogenously produced in cells by the enzyme heme oxygenase-1 (HO-1), functions as an important signaling mediator endowed with strong anti-inflammatory activities. However, the mode(s) by which CO elicits these effects remains to be elucidated. Although CO is a renowned inhibitor of mitochondrial respiration at high concentrations, recent results reveal that low doses of CO positively modulate mitochondrial function. The current proposal aims to investigate how the interaction of CO with mitochondria affects its anti-inflammatory activity in microglia. Innovative chemical entities and methodological approaches will be employed to dissect the different functions of CO in this context, including: 1) CO-releasing molecules, which deliver precise amounts of CO to biological systems; 2) a new class of hybrid molecules composed of a CO-releasing moiety coordinated to an electrophilic structure known to induce HO-1 expression; 3) a Seahorse Analyser to perform an in-depth biochemical analysis of the effect(s) of CO on mitochondrial bioenergetics and how this may lead to a reduced inflammatory response, and; 4) whole-genome transcriptome profiling of primary microglia cells focusing on the effects of CO on genes involved in ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Beyond compliance: Rethinking the Effectiveness of Regional Human Rights Regimes' (BeyondCompliance).

assistant: **Innovation**

The European, African and inter-American human rights regimes seem not to be effective vis--vis non-democratic states. Besides undermining the international rule-based order, this situation has dire implications for human rights victims. Conventional theories, based on the experience of the European Court of Human Rights (ECtHR), equate the effectiveness of regional courts with compliance. This perspective is inadequate to explain the status quo, where illiberal states may execute individual rulings while violating the underpinning norms. Scholarship on the Global South suggests that the experiences of the inter-American Court of Human Rights (IACtHR) and the African Court of Human and Peoples Rights (ACtHPR) offer an underexplored potential to increase our understanding, and a great potential to draw lessons for the European context, which is increasingly dealing with illiberal regimes. From a compliance perspective, the IACtHR and the ACtHPR have been hardly effective. Yet, if we take broader societal impact as an indicator, their experiences might indeed provide us with important insights. The project asks: What are the limitations and possibilities for human rights regimes to be effective in non-democratic contexts? It starts from the working assumption that regimes can only be effective if they make full use of their oversight powers (exhaustiveness) and empower domestic activists in their mobilization (responsiveness). It tests this view by analyzing how the three regimes have enforced their norms against states engaging in: 1) violence, 2) legal repression, and/or 3) rule of law violations. Based on case law analysis and interviews, it will develop an empirically based theory on effectiveness in three steps: 1) a historical analysis to identify the three regimes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Neural basis of zebrafish collective decision-making' (CollectiveDecisions) under Horizon Europe.

assistant: **Objectives**

It is challenging for isolated animals to reliably extract and integrate behaviorally relevant information from the natural environment. Due to the limited sensory capacity of individuals, many animal species therefore share and evaluate cues collectively, allowing them to solve complex decision-making tasks as a group. The behavioral algorithms and neural mechanisms that give rise to these cognitive abilities remain poorly understood. In many fish species, these behaviors are largely vision-based, providing the opportunity to decipher the underlying general computational principles under well-controlled experimental conditions in the lab. At the same time, it is becoming possible to employ powerful neuroscientific techniques, enabling new detailed analyses of the neural circuitry that orchestrates behavior. I propose to establish the juvenile zebrafish as a model system that is optimally suited for the study of collective decision-making. At this intermediate developmental stage, zebrafish offer an excellent compromise between cognitive ability and experimental accessibility. They can temporally and spatially integrate information, they start to socially interact, and one can characterize and manipulate brain activity in intact behaving animals. Using closed-loop virtual reality experiments, I will initially dissect the algorithmic rules by which juvenile zebrafish make decisions when swimming in heterogeneously biased groups. I will then characterize brain activity related to this behavior, in freely swimming fish, and in restrained preparations. Finally, to causally link neural circuit function and group decision-making performance, I will carry out targeted laser ablation and optogenetic activation experiments. Thus, my proposed research in juvenile zebrafish will,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An open or closed process: Determining the global scheme of perception'.

assistant: **Objectives**

Despite decades of intensive research, there is no agreement about the general scheme of perception: Is the external object a trigger for a brain-internal process (open-loop perception, OLP) or is the object included in brain dynamics during the entire perceptual process (closed-loop perception, CLP)? HOWPER is designed to provide a definite answer to this question in the cases of human touch and vision. What enables this critical test is our development of an explicit CLP hypothesis, which will be contrasted, via specific testable predictions, with the OLP scheme. In the event that CLP is validated, HOWPER will introduce a radical paradigm shift in the study of perception, since almost all current experiments are guided, implicitly or explicitly, by the OLP scheme. If OLP is confirmed, HOWPER will provide the first formal affirmation for its superiority over CLP.Our approach in this novel paradigm is based on a triangle of interactive efforts comprising theory, analytical experiments, and synthetic experiments. The theoretical effort (WP1) will be based on the core theoretical framework already developed in our lab. The analytical experiments (WP2) will involve human perceivers. The synthetic experiments (WP3) will be performed on synthesized artificial perceivers. The fourth WP will exploit our novel rat-machine hybrid model for testing the neural applicability of the insights gained in the other WPs, whereas the fifth WP will translate our insights into novel visual-to-tactile sensory substitution algorithms.HOWPER is expected to either revolutionize or significantly advance the field of human perception, to greatly improve visual to tactile sensory substitution approaches and to contribute novel biomimetic algorithms for autonomous robotic agents.


**Keywords:** ac