RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Ultra Low emission Technology Innovations for Mid-century Aircraft Turbine Engines' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With the ULTIMATE project five experienced research groups and four major European engine manufacturers will develop innovative propulsion systems to fulfill the SRIA 2050 key challenges. One of the most challenging targets is the 75% reduction in energy consumption and CO2-emissions. Technologies currently at TRL 3-5, cannot achieve this aim. It is estimated that around a 30% reduction must come from radical innovations now being at lower TRL. Thus, European industry needs synergetic breakthrough technologies for every part of the air transport system, including the airframe, propulsion and power. The ULTIMATE project singles out the major loss sources in a state of the art turbofan (combustor irreversibility, core exhaust heat, bypass exhaust kinetic energy). These are then used to categorize breakthrough technologies (e.g. piston topping, intercooling & exhaust heat exchangers, and advanced propulsor & integration concepts). This classification approach gives a structured way to combine and explore synergies between the technologies in the search for ultralow CO2, NOx and noise emissions. The most promising combinations of radical technologies will then be developed for a short range European and a long range intercontinental advanced tube and wing aircraft.Through the EU projects VITAL, NEWAC, DREAM, LEMCOTEC, E-BREAK and ENOVAL, the ULTIMATE partners have gained the most comprehensive experience in Europe on conception and evaluation of advanced aero engine architectures. Existing tools, knowledge and models will be used to perform optimization and evaluation against the SRIA targets to mature the technologies to TRL 2. Road maps will be set up to outline the steps to develop the technologies into products and bring them onto the market. These road maps will also p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ultracold Molecules in Optical Trap Arrays' (UMOTA) under Horizon 2020.

assistant: **Objectives**

Classical computers quickly hit the brick wall when asked to model the behavior of interacting quantum systems. For example, calculating the time evolution of a quantum system consisting of only 40 interacting spin-½ particles is believed to be fundamentally impossible on a classical computer. Fortunately, the direct investigation of such systems is coming into the reach of today’s most powerful quantum simulators. In this approach, a controllable quantum system is used to model the behavior of other less accessible systems of interest.  I plan to make a versatile, reconfigurable array of strongly-polar Calcium Monofluoride (CaF) molecules, and investigate its utility as a scalable quantum simulator.  These ultracold molecules have long lifetimes and interact over large distances via their strong electric and magnetic dipole moments. They can thus be used to investigate a wide range of many-body quantum phenomena and are promising candidates for the simulation of lattice spin models, which are omnipresent in condensed matter physics.In the Center for Cold Matter at Imperial College London, CaF has recently been magneto-optically trapped and laser-cooled to a record-breaking temperature of 50µK. As an MSCA fellow I will build upon these results. I will develop techniques to confine a single CaF molecule in an optical tweezer trap, then assemble a controllable array of molecules using multiple tweezer traps, and finally investigate the entangling dipole-dipole interaction between two neighboring molecules by coherent microwave control. These experiments will take place in a complexity regime where results can still be numerically simulated and will thus serve as benchmark tests of a future scalable quantum simulator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Circuit analysis of thalamic visual processing and its modulation by long-range projections'.

assistant: **Concept**

The thalamus, whose anatomical history goes back two millenia, has long been recognized as the master relay for sensory information propagating to cortex and consciousness. Yet, it is indisputable that thalamic nuclei are much more than simple relays but integrate different sensory modalities, bottom-up as well as top-down information. One elementary form of top-down modulation is attention, which selectively enhances behaviorally relevant information. Attentional modulation occurs already at the thalamus by, yet, unresolved circuit mechanisms. My research specifically aims at (1) exploring circuits for long-range, top-down modulation of thalamic visual processing, (2) dissecting the circuitry underlying attentional modulation, and (3) understanding basic rules of thalamic information processing. I will pursuit these three aims using an innovative combination of monosynaptic retrograde rabies tracing, optogenetics and deep 2-photon calcium imaging. My experiments will focus on the lateral geniculate nucleus (LGN), which is the main connection between the optic nerve and the visual cortex, as well as on the thalamic reticular nucleus (TRN), which provides major inhibitory input to LGN and has previously been implicated in attentional regulation. Notably, TRN deficits have been suggested to contribute to the clinical symptoms of schizophrenia. By rabies tracing, I will target channelrhodopsin to monosynaptic long-range inputs to the visual thalamus. By GRIN-lens assisted 2-photon imaging I will quantify visual responses and search for signatures of attentional modulation that can be induced by optogenetic stimulation of specific inputs. This approach will allow me to quantify attentional modulation of thalamic information-processing by specific long-range inputs, to disse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'PROMOTING ICT DIALOGUE AND COOPERATION WITH THE MPC TOWARDS HORIZON 2020'.

assistant: **Objectives**

In line with the new concept in Horizon 2020 which integrates industrial cooperation and innovation, and the need to go beyond the old extended workbench" principle, two are the most important aspects of such ex-tension:1) to incorporate ETPs2) to increase the participation of innovation driven SMEs from both sides.In this transition between FP7 ending and the launch of HORIZON 2020, comes the MED-Dialogue Support Action, brought forward by a balanced mixture of 7 MPC governmental and academic organisations directly involved in the elaboration of policies and on the promotion of the Research and Development cooperation locally and internationally, 4 EU partners experienced in Management and Strategy Consulting in the areas of Technology Re-search and Development, Industrial and Innovation Policies, and IT Research, highly experienced in the European Framework Programmes,supported by an advisory group of more than 20 influential and knowledgeable stakeholders from the entire MPC regionMED-Dialogue is a bridge for a two-way cooperation between the MPC and the EU aiming at four main objectives:A:  Support through a flexible modular approach the Dialogue between EU and the Region in any form or structure, be that political, technical, formal, informal, by providing on demand customized timely in-put solidly documented on all the new Horizon 2020 concept aspects.B:  Raise awareness on the H2020 first Calls and assist the organisations in the Region to prepare proposals and find partners in order to increase their participation in the Programme.C: Support the EC in the preparation of the Horizon 2020 workprogramme 2016-17, by identifying the strengths and opportunities in the MPC (through the identified and validated ICT priorities) for mutually beneficial cooperation.D:  S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Generational approach to the Social Patterns of Relation to Work' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project focuses on the factors leading to solidarity or tensions in intergenerational relations, in the area of work. Recent researches raised the hypothesis that the younger generation have different attitudes, forms of participation, expectations and engagement in work than the older generations. The pessimistic view often concludes on an increased individualism. This rapid assumption is not founded on robust research. The project will provide a better understanding of the evolving relation that generations have with work. Such changes have important consequences on the intergenerational relations at the workplace, on solidarity between generations, but also on the relevance of specific work and employment policies as well as on other public policies. The relation to work is analysed through different angles: value given to work, expectations associated to work, vision of the future, relation to precariousness, relation to mobility, more generally the construction of an identity through work and the linking with other key issues. A link is also establipshed between the relation to work and other correlated issues: family formation and lifestyles, intergenerational relations in society, social inclusion or exclusion. The gender dimension and the position of migrants are constitutive and transverals aspects of all research tasks. The project also analyse age policies related to work and employment and identifies good practices. The research methodology combines qualitative, quantitative, comparative and participary approaches. The key objectives are to draw out social patterns of relation to work for different generations, including the gender dimension; to study articulations with other societal fields (family formation and lifestyles, intergenerational relations,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Earth system Model Bias Reduction and assessing Abrupt Climate change' to be submitted under Seventh Framework.

assistant: **Abstract**

EMBRACE brings together the leading Earth System Models (ESMs) in Europe around a common set of objectives to improve our ability to (i) simulate the Earth System and (ii) make reliable projections of future global change. EMBRACE builds on the existing European collaboration network in Earth System Modelling and will be the main European input to international efforts in this field over the coming 5 years. The project has a number of key goals; (i) to reduce the main, known biases in existing European ESMs, (ii) to fully evaluate ESM simulation capabilities and improvements made in the project, (iii) to increase the realism of, and interactions between, the physical and biogeochemical components of ESMs, (iv) to assess the risks of abrupt or irreversible changes in key components of the Earth system, in response to the most recent greenhouse gas, aerosol and land-use scenarios proposed for the IPCC AR5.The primary ESM biases targeted for improvement include, (i) the representation of moist atmospheric convection and links to coupled tropical variability and precipitation. (ii) equatorial and coastal ocean upwelling and their impact on the global climate system and carbon cycle, (iii) coupled processes controlling physical and biogeochemical mixing in the Southern ocean, (iv) soil hydrology and its coupling with the atmosphere and (v) the terrestrial carbon cycle, through a more realistic treatment of climate-vegetation interaction. Improvements will be evaluated in the context of the full range of CMIP5 historical simulations, with the CMIP5 protocol forming the basis for future climate projections made to assess the risk of abrupt changes. A cross-cutting theme will be the impact of improved process description, combined with increased coupled model resolution, in red
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spatial organization of photosynthetic complexes in membranes' (ORGANIZATION) targeting Sixth Framework.

assistant: **Abstract**

One of the most intriguing questions in biological and biophysical research is still how proteins are spatially organized in membranes and subsequently how the organization influences the biological function of a protein in particular and of the organism in general. Also for photosynthetic organisms the membrane organization of the various photosynthetic components is far from being understood. One of the simplest photosynthetic organisms are purple bacteria. Thus they were widely used as a model system in order to understand the underlying principles of the photosynthetic process. For the photosynthetic apparatus of purple bacteria, which mostly consists of the light-harvesting complexes (LH) 2 (3), LH2 and the reaction centre (RC), some elaborated models have been proposed. But for our understanding of the photosynthetic process not only the actual organization of the pigment-protein complexes in the membrane is crucial, but also which parameters actually influence the organization of the complexes with respect to each other.The objective of the proposed project is therefore to elucidate the underlying mechanisms for the organization in the photosynthetic membrane in order to contribute to a better understanding of the photosynthetic process in general and of membrane organization in particular. We will investigate the research objective by reconstituting the components of the photosynthetic apparatus of purple bacteria in model membranes and study the organisation and dynamics in the membrane as a function of light conditions, protein concentration, membrane composition, presence of additional membrane components and temperature. For our studies we want to take advantage of the technical progress in the single-molecule field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nerve-on-Chips' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Neurodegenerative diseases (“ND”) are devastating as they cause individuals to lose their memories, independence, and ultimately, their lives. In the absence of drugs able to cureor prevent start of ND, the latter are a human and financial burden for individual patients, their relativesthe health care system and society in general. The worldwide economic impact of ND is evaluated at $2 trillion a year. The incidence of ND is expected to grow in the coming few years as life expectancy increases. In 2020, over 65 million people will suffer from Alzheimer Disease worldwide (over 6.5 million in the EU).MicroBrain Biotech is an innovative biotech startup founded in 2014. MBBT aims at offering “turn-key solutions” to biopharmaceutical research which will take the shape of microfluidic chips offering different types of reconstructed neuron networks at the micron scale. These chips are called Nerve-on-Chips (“NoC”, subcategory of Organ-on-Chips), and they simulate the function of tissues and organ subunits. Our patented NOC technology provides many advantages over other in vitro models such as conventional two-dimensional (2D) and tri-dimensional (3D) culture systems, over organoids, and over animal models:-    Reduce biopharmaceutical R&D costs and increased efficiency in clinical research (improved competitiveness)-    Reduce animal testing-    Predicting human-relevant drug responses-    Compatibility with readouts used in biology & real time visualization-    Reconstitution of complex organ-level physiological functionsNOC will allow to reduce drug R&D costs by 15% which will generate a total turnover worth €30 million. MBBT’s objective is to reach a €2 million worth turnover (i.e.: 8% OOC market share) within the 3 next years. The feasibility study will allow us to ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The role of CXCR4 receptor in Ewing sarcoma angiogenesis: a single-molecule and super-resolution microscopy study' (CXCR4) under Seventh Framework.

assistant: **Objectives**

Directed cell movement in a chemical gradient, chemotaxis, is a prerequisite for many vital processes like the immune response and wound healing, but it is also the basis for cancer spreading (metastasis). It is governed by extracellular gradients of signal molecules. While the receptors in the cell membrane are mostly identified, it is still unknown how the cell builds up the phenotype with defined front and rear edge required for directed movement In this project two potential ordering parameters, receptor mobility and cytoskeleton induced membrane domains, will be investigated on a molecular level in mouse fibroblasts and Ewing sarcoma cells embedded in 2D and 3D biomimetic matrices. The fellow will develop a combination of two actual technologies, single-molecule microscopy (SMM) and super-resolution imaging to study the diffusive behaviour of the receptors and simultaneously observe the organization of the actin network, both at the 10 nm level. Elucidating the influence of the physical organization on the establishment of cell polarity will allow her to specify a model to explain the sensitive and robust mechanisms of chemotaxis. This multidisciplinary project will be realized at the Leiden Institute of Physics, a lab which has developed the life cell SMM technology, in collaboration with the Leiden Institute of Biology and the Leiden University Medical Centre. Spatial and temporal understanding of cancer cell migratory mechanisms will be a crucial breakthrough in combining physical and biological efforts to fight cancer. The fellow will acquire skills on cutting edge microscopy, molecular cell biology, and extend her network towards the biophysical community in the host country. The unique technique developed in this study will provide the basis of the fellow’s f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanobody-enabled Structural Investigation of a G Protein-Coupled Receptor-Arrestin Complex' (NESIAC) targeting Horizon 2020.

assistant: **Abstract**

Although many thousands of transient protein-protein interactions (PPIs) are known, there is a disturbing paucity of high-resolution structures of the resulting complexes and the difficulties involved in experimentally determining these atomic structures remain essentially unaddressed.The Steyaert lab has shown that cross-linking transiently interacting proteins, followed by immunization of llama’s with this cross-linked antigen, causes the maturation of single domain antibodies called Nanobodies (Nbs). The Nbs bind composite conformational epitopes unique to the transient complex. Highly efficient selection methods can discriminate Nbs that exclusively bind the transient (non-cross-linked) complex from binders that bind to the dissociated monomers. Such Nbs will be instrumental to purify and solve the structures of PPIs that have been resistant to investigation by X-ray, NMR, SAXS or EM and for the functional analysis of these complexes within a living cell. This ground-breaking technology will be validated with well-chosen case studies covering key PPIs of the GPCR transmembrane signaling pathway including parts of the arrestin interactome. During this project the fellow will establish a unique research niche by systematically applying her arsenal of learnt techniques to develop the next generation antibody‐enabled methods for the structural investigation of the GPCR-arrestin targets. The ultimate goal of NESIAC is to determine the atomic structures of the most relevant transient associations of these signaling proteins. This will open up a new platform for realising the structural basis of the elusive GPCR regulation by arrestins.