RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Integrated system for safe transportation of children to school'.

assistant: **Concept**

Between 1994 and 2001, 361 children were injured or killed during transportation to/from their school in Sweden, whereas 455 were killed or injured in Austria only in 2007 and 97 were killed in Italy in 2005. In a single school bus accident in Greece in 2003, 20 children lost their lives. Different as the above numbers may be, they all tell us one thing: Crashes involving school buses and crashes involving children traveling from/to school, are far from negligible and require further efforts to be drastically reduced.SAFEWAY2SCHOOL aims to design, develop, integrate and evaluate technologies for providing a holistic and safe transportation service for children, from their home door to the school door and vice versa, encompassing tools, services and training for all key actors in the relevant transportation chain. These include optimal route planning and rerouting for school buses to maximize safety, on-board safety applications (i.e. for speed control and seat belts), “intelligent” bus stops, effective warning and information systems for bus drivers, children, parents and the surrounding traffic; as well as training schemes for all actors. The project innovative systems, services and training schemes will be tested in 4 sites Europewide, including North (Sweden), Central (Austria), South (Italy) and Eastern (Poland) Europe; to evaluate their usability, efficiency, user acceptance and market viability; taking into account the very different children’s transportation to/from school systems across the different European regions as well as key cultural and socio-economic aspects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Stress induced microspore embryogenesis' in the context of a Fourth Framework call.

assistant: **Objectives**

We want to understand the mechanism of stress-dependent, embryogenic induction in isolated, in-vitro cultured microspores and to use this knowledge for a genotype-independent production of doubled haploid plants in the crop plants barley, wheat, maize and carrot, as well as the model plant Arabidopsis thaliana. Doubled haploid breeding relates to the core of Mendelia plant breeding, i.e. the production of homozygous lines in sexually reproducing plants which transmit their traits to the offspring in a stable fashion. Doubled haploid breeding is an important tool to develop new cultivars directed to new demands in a much shorter time than by conventional breeding. A genotype- independent doubled haploid production would also be the core technology for a genotype-independent production of transgenic lines. There exist a number of techniques for the production of doubled haploids. In the last years the technique of isolated microspore cultures has emerged. This breakthrough has been achieved by the recognition that stress is the major trigger for embryogenic induction in microspores and that a combination of stress treatments allows a very large traction of microspores from a given plant to develop into plants. Furthermore, progress in transformation technology and the molecular analysis of pollen development and microspore embryogenesis has provided a number of useful developmental marker genes which can be used profitably for various purposes. Microspore embryogenesis offers unique advantages to study plant embryogenesis, mainly due to the high number of microspores a plant produces in a naturally synchronous manner. This facilitates cell biological, biochemical, molecular and genetic analysis. In the SIME (stress-induced microspore embryogenesis) project, we want to stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unravelling neuroimmune crosstalk to find novel treatment targets for inflammatory bowel disease'.

assistant: **Innovation**

Up to 40% of patients with inflammatory bowel disease (IBD) do not respond to standard of care treatment with anti-inflammatory drugs. Unfortunately, the mechanisms driving persistent inflammation are unknown, resulting in a lack of specific therapies and an important burden for patients and society. Enteric neurons are highly specialized cells that sense and respond to nutrients, microbial products and inflammatory signals and densely innervate the gut. Besides regulating gastrointestinal motility, emerging studies indicate that crosstalk between enteric neurons and immune cells regulates inflammation, tissue homeostasis and antimicrobial immunity. However, this has not been investigated in the context of IBD. I hypothesize that enteric neurons become rewired during IBD and acquire an inflammatory signature that amplifies inflammation. Recent technological advancements will allow the investigation of enteric neurons via the use of cutting-edge tools in microfluidic droplet generation, molecular biology and functional genomics. We will leverage the Xavier lab’s expertise in the field of the enteric nervous system at the Broad Institute of MIT and Harvard during the outgoing phase, the expertise of Dr. D’Haens in IBD during the return phase at the Amsterdam University Medical Center and my expertise in pre-clinical IBD models in vitro and in vivo to characterize the role of enteric neurons in IBD for the first time and find potential treatment targets.


**Keywords:** IBD, inflammatory bowel disease, Crohn's disease, ulcerative colitis, enteric nervous system, enteric neurons, gastroenterology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Long-term molecular nanoscale imaging of neuronal function'.

assistant: **Innovation**

Synaptic function is difficult to analyze in living neurons using conventional optics, since the synaptic organelles and protein clusters are small and tightly spaced. The solution to this problem can come from the field of super-resolution fluorescence microscopy, or nanoscopy. However, the current approaches to nanoscopy are still far from reaching this goal. Single molecule-based approaches (including STORM and PALM) provide high spatial resolution, but slow recording, insufficient for live imaging. Ensemble approaches (including SSIM and STED) are able to record faster, but with poorer resolution or with high, potentially toxic, laser powers. It is currently impossible to image the same neuron for hours and days, with both high spatial (~30 nm) and temporal (10-1000 Hz) resolution, and with minimal photodamage. My aim is to fill this gap, by developing, for the first time, a microscope that combines the advantages of both single molecule-based and ensemble approaches. I will base the microscope on RESOLFT, a low-photodamage ensemble approach that I have pioneered recently. I will use line patterns to speed up the recording and 2photon-switching for 3D ability. I will combine this with sensitive detection schemes that allow single-molecule detection and counting, relying on my previous expertise with PALM and GSDIM. The new set-up, termed molecular nanoscale long-term imaging with sequential acquisition (MoNaLISA), will track neuronal organelles and proteins on different time scales, spanning from milliseconds to days, with a resolution close to the molecular scale. To obtain the first proof-of-principle results, I will address several issues still open in the synaptic transmission field, relating to synaptic vesicle recycling, biogenesis and degradation. Overall, my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cybersecurity and privacy dialogue between Europe and Japan' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The EUNITY project addresses scope 2 (international dialogue with Japan) of objective DS-05-2016 of the H2020 work programme. This two years project aims at developing and encouraging the dialogue between Europe and Japan on cybersecurity and privacy topics. The partners involved have a long-standing history of research on both topics at the European level, as well as cooperation with Japan.EUNITY has 3 main objectives:1.Encourage, facilitate and support the ICT dialogue between relevant EU and Japanese stakeholders on matters relating to cybersecurity and privacy research and innovation issues;2.Identify potential opportunities for future cooperation between European and Japanese research and innovation ecosystems; and3.Foster and promote European cybersecurity innovation activities and increase the international visibility of EU activities in cybersecurity.To meet these objectives, EUNITY will first gather relevant stakeholders in at least two workshops, one in each geography (EU and JP), taking advantage of co-location with other events as much as possible. It will also thanks to the expertise of its members collect the appropriate existing research agendas, legislations and business practices in Europe and Japan. It will then analyze the information collected to formulate recommendations, including business opportunities and a research agenda. A particular attention will be brought to the similarities of the research and market strategies, as well as the differences that must be taken into account when addressing both markets.EUNITY will operate in close relationship with the European Cyber Security Organization association, the cybersecurity cPPP signatory with the Commission. EUNITY will cover all the constituencies of ECSO (large organizations, SMEs, public bodie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Organic viticulture and wine-making: development of environment and consumer friendly technologies for organic wine quality improvement and scientifically based legislative framework' (ORWINE) under Sixth Framework.

assistant: **Objectives**

The project aims at developing the legislative framework for wine from organic viticulture. Data about currently applied practices, consumer and market needs in significant areas will be gathered in significant wine producing areas of EU, new member states and accession countries. Test series with suitable and innovative technologies to improve the quality of wines from organic viticulture, allowing to use a low level of sulphites will be conducted and validated on selected pilot farms. A participatory approach with stakeholder involvement on national and EU levels will be followed, ensuring a high acceptance of the proposed legislative framework. A code of best practises and an integrated environment assessment tool shall give guidance for wine-producers to produce high quality wine while limiting their impact on the environment. The projects has following objectives: to identify practices applied in organic viticulture and wine making in typical EU and AC wine producing areas and evaluate their impact on environment and wine quality (WP2); to identify buying motives and organic wine markets needs in order to address labelling provisions and communication strategies (WP 2); to develop innovative wine-making technologies fitting to the organic concept and improving organic wine quality with particular regard to sulphites reduction (WP3); to test on-farm innovative technologies in order to assess their practicability and acceptability (WP4); to develop a code of best organic wine-making practises and recommendations for the development of EU regulation 2092/91 and policy support measures for the organic wine sector through a participatory approach (WP5). The project partnership consists of 11 partners from 4 countries (I, F, D, CH), a SME and an European Organisation, co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Data-Driven Design of Disordered Materials' to be submitted under Horizon 2020.

assistant: **Abstract**

With increasingly advanced manufacturing techniques, architected materials or metamaterials continue to gain popularity. Researchers have produced ultrastrong, ultrastiff and ultralight metamaterials, whose anomalous properties emerge upon mechanical actuation. Their vast majority are designed with a periodic and regular lattice structure. On the other hand, architected disordered materials have received little attention (e.g. earlier studies on foams) despite their robustness and flaw tolerance compared to regular lattice-based materials. This is largely due to their vast design space, which has been inaccessible with standard sampling techniques. The aim of the project D4M (DEFORM) is the development of a novel rational framework for material design, that systematically exploits disorder, and is completely data-driven, and hence experience-free. The framework relies on four synergistic elements: i) a unified network-theoretic representation of disordered material architectures, ii) the use of mechanics and complex networks as tools for evaluating design objectives, iii) the development of efficient graph machine learning techniques for executing the design, and iv) the practical implementation and validation of a suite of designs by additive manufacturing and testing. By focusing on design objectives such as high energy absorption and tailored nonlinear deformation response, the proposed research is expected to have a diverse impact in the design of cellular, granular and fibrous materials with applications in biomechanics (prosthetics, orthotics, bioimplants) and the sports industry (protective equipment, clothing, shoes). The implications of the proposed research stretch beyond these engineering applications and into the scientific understanding of complex biologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cooler Synchrotron and Storage Ring COSY' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Principal characteristics of the facility and of the support offered to users: The Forschungszentrum Julich is a German national laboratory which carries out research in different fields. The accelerator COSY of the center is used for medium energy hadron physics studies. This cooler synchrotron provides beams of protons with energies of up to 2.6 GeV with electron and stochastic phase space cooling. Presently unpolarized beams are used for the experimental studies, the acceleration of polarized protons is under development. Experiments are performed with thin targets inside the accelerator ring and with extracted beam. High beam quality is achieved through phase space cooling (electron cooling at present, stochastic cooling under commissioning). Beam intensities amount of 1011 protons per spill. As a fully computer controlled device COSY is very flexible with respect to beam handling and the selection of beam energies. Measurements of energy dependent observables during acceleration and the investigation of processes very close to threshold are possible. Four installations for research with intemal targets and three external target positions are available and are presently used for the investigations of meson production of proton-proton elastic scattering and of the modification of elementary processes in-medium. The research is carried out by internal and external users in international collaborations including theoretical experts. COSY will under the proposed EU contract be given full access to the experimental facilities of the reserach center, e.g. beam time at the accelerators, computing facilities, data acquisition systems, electronics, technical assistance from the local staff, of fice space, help to arrange housing. Proposed experiments will be evaluated by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Developing and Testing a novel, low-cost, effective HOOKworm VACcine to Control Human Hookworm Infection in endemic countries'.

assistant: **Concept**

Approximately 600-700 million people are infected by hookworm, primarily in sub-Saharan Africa, Southeast Asia, and Latin America. Hookworm infection ranks number one in terms of Years Lost from Disability from a neglected infectious disease, and among the top 3 in terms of lost Disability-Adjusted Life Years. HOOKVAC will be developing the first and only vaccine for human hookworm infection.   A bivalent, low-cost vaccine candidate will be clinically tested for the first time in an African disease endemic population. This will be done in Gabon in a very typical setting within the Central African rainforest belt, where the incidence of hookworm infections is 30%. Inspired by preparatory research, HOOKVAC believes that it can develop the vaccine with at least 80% efficacy against moderate and heavy hookworm infections that lasts at five years after immunization. Cost effectiveness modelling has shown that such a vaccine will significantly improve the efficacy of the current mass drug administration programs.  HOOKVAC will play a crucial role in advancing toward large scale efficacy studies in African endemic areas.  Via a program of 48 months with 6 work packages, HOOKVAC will address 4 main objectives: (1) establish safety and immunogenicity of the vaccine candidate in an endemic population (2) improve the manufacturing process (3) provide clinical proof of concept (4) improve accessibility of the vaccine in endemic areas. The involvement of European SMEs in the project is a critical component to advancing a successful vaccine, and an integral part of adding private sector know-how and scientific expertise to the project. This will inspire other European SMEs to become more involved in public/private vaccine product development for neglected infectious diseases. By doin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural analysis of the interaction of the chromatin associated factor Dot1 with chromatin and mixed-lineage-leukemia fusion proteins' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Chromatin structure is influenced by covalent modifications of histones which lead to the recruitment of proteins that recognize specific regions in the genome. Histones undergo a variety of post-translational modifications. These modifications modulate a multitude of DNA based processes such as transcription, repair, replication and chromatin dynamics. Methylation is one of these important modifications. In this proposal the histone methyltransferase Dot1 (disruptor of telomeric silencing) is investigated. Dot1 methylates lysine 79 located in the globular histone-fold of histone H3 and is therefore the first histone modification enzyme discovered that modifies a residue in the core region and not in the N-terminal part. This methylation requires minimally a nucleosome core particle (NCP), consisting of 147bp of DNA and a histone octamer containing a central H3-H4 tetramer and two H2A-H2B dimers. The ability of Dot1 to bind and modify a nucleosomal substrate makes it an ideal model enzyme to study the interaction of the nucleosome with such regulatory factors. In this approach x-ray crystallography combined with disulphide crosslinking will be used to study the Dot1/NCP interaction. Heterochromatic gene silencing, DNA repair, embryonic development and human leukemia are only some of the processes Dot1 is involved in and they also contribute greatly to its interest. As part of leukemia pathogenesis Dot1 was shown to interact with the MLL (mixed lineage leukemia) fusion protein AF10, Dot1 therefore plays a significant role in misregulation of MLL oncogenes. The structural information obtained by x-ray crystallography about the Dot1/AF10 interaction will give insights into leukemia pathogenesis whereas structural studies of the Dot1/chromatin interaction would be a major s