RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Liquid liquid phase separation mediated protein fibrillation leading to neurodegenerative diseases'.

assistant: **Concept**

Neurodegenerative disorders are the leading cause of physical and cognitive disability, currently affecting ~15% population worldwide with estimated global cost of healthcare accosiated with them expected to at least double in the next 20 years. Five most common neurodegenerative diseases, including ALS and FTD, are linked to formation of protein deposits in patient tissues and are currently without treatment options that would prevent or alter the disease progression. ALS and FTD pathology is characterised by accumulation and formation of insoluble protein deposits formed by  proteins, like  TDP-43, FUS and DAXX. These proteins undergo liquid-liquid phase transition (LLPS) in cells forming non-membrane bound organelles, which are important in RNA processing and stress responses of cells but their dysregulation acts a precursor to protein fibrillation. In this project we will, therefore, combine traditional biophysical approaches with modern molecular dynamics simulations and solution state nuclear magnetic resonance to discern this complex behaviour leading to LLPS, and gain molecular insight into its onset. Major outcomes of the project are (1) Develop the necessary simulation tools by reparametrizing currently available force fields using experimental data; (2) Apply the simulation tool and analytical methods to interactions between oligonucleotides and ions with proteins and compare results to experimental data; (3) Map phases and coacervation of DAXX in the presence of nucleotides and ions; (4) identify residues crucial for fibrillation and determine their role in cellular LLPS;  (5) Apply high-throughput virtual screening to design proteins aggregation breaking ligands with therapeutic potential Outcomes of this project will importantly enhance our understanding a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamic Microfluidic Deflection Systems for High Throughput Single Platelet Function Testing' in the context of a Seventh Framework call.

assistant: **Objectives**

Single activated platelets can activate other platelets to drive blood clotting. Single, hyper-sensitive platelets could coordinate clotting in healthy individuals or cause pathological clotting in high risk groups such as the elderly, obese peoples and smokers. To identify potentially rare hypersensitive platelets, an assay must enable high throughput population profiling with all platelets isolated to avoid cross-talk. Platelet activation is associated with a <5 second transformation from a discoid to a stellate morphology and with zeta-potential changes caused by membrane inversion. However, heterogeneity within the population prevents the fractionation of hypersensitive platelets using size and charge based deflection fields. The proposed research aims to solve these challenges using bespoke microfluidic platforms integrating a biochemical switch with deterministic lateral displacement or free-flow electrophoresis deflection fields for imaging platelet trajectories DURING activation. Critically, TRAJECTORY CHANGES, consistent with platelet reorganisation dynamics, are DIAGNOSTIC for ACTIVATION and the continuous flow format generates a single-file platelet stream, effectively isolating platelets from one another. Effective size, shape and charge components of deflection will be elucidated to provide new insights into platelet activation dynamics. Platelets from healthy and high risk cohorts will be screened to identify hyper-sensitive populations and determine therapeutic doses required to desensitise the hypersensitive platelets. This multidisciplinary research will create a paradigm shift, from a population to a single platelet perspective. This discovery to diagnostics work program has great potential to generate intellectual property to underpin commercializatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dynamic interactive chemical biology and biomedicine' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This network involves the training of researchers to acquire particular skills in the highly interactive field of chemical biology & biomedicine. It will rely on the interplay with the emerging concept of Constitutional Dynamic Chemistry to produce molecular diversity, and Glycobiology as a field of application. Dynamic chemistry allows for the generation of large compound arrays based on reversible processes, and enables the acquisition of new structures applicable to the study of complex carbohydrate interactions. Understanding these interactions is of great importance in biology and will eventually lead to new biomedical applications.The specific objectives are to:1. Provide advanced interdisciplinary training in chemical biology & biomedicine, using a dynamic chemistry/glycobiology platform, to early stage- and experienced researchers. These will undergo highly interactive research projects, encompassing chemistry, biology, medicine and biophysics, addressing the development of new applications in glycobiology. Intense courses and workshops will provide a profound theoretical basis and prepare them for successful futures in European R&D.2. Provide international and intercultural training in a network of highly skilled research groups throughout Europe. The extended cultural integration asks for human resources with solid understanding and communicative skills, and the programme is designed to provide trained scientists that are resting on European cultural grounds, capable of challenging international competition.3. Provide intersectorial training between academic groups and industrial partners. A strong hold on industrial research prerequisites is key to successful training in all aspects of science and technology, and the programme aims to introduce the researcher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'REnaissance of Places with Innovative Citizenship and TEchnolgy' (REPLICATE).

assistant: **Concept**

The objective of REPLICATE is to demonstrate Smart City technologies in energy, transport and ICT in districts in San Sebastia, Florence and Bristol addressing urban complexity and generate replication plans in other districts and in follower cities of Essen,Nilufer and Lausanne.Main challenges for cities are to increase the overall energy efficiency, to exploit better local resources in terms of energysupply and demand side measures. For successful implementation of Smart City technologies two main elements areconsidered:- Cities are the customer: considering local specificities in integrated urban plans and the need to develop monitoringsystems to extract conclusions for replication.- Solutions must be replicable, interoperable and scalable.REPLICATE considers also the complexity of cities, the tangible benefits for citizens, the financial mechanisms and the newbusiness models. The 3 pillars implemented in the pilots with the engagement of citizens, private actors and authorities are:- Low energy districts: cost-effective retrofitting, new constructive techniques with optimal energy behaviour and highenthalpy RES in residential buildings. Include also efficient measures in public and residential buildings: ICT tools, PV,shading or natural ventilation; district heating is demonstrated hybridising local biomass, recovered heat and natural gas.- Integrated Infrastructure: deployment of ICT architecture, from internet of things to applications, to integrate the solutions indifferent areas. Smart Grids on electricity distribution network to address the new challenges, connecting all users:consumers, producers, aggregators and municipality. Intelligent lighting will allow automated regulation of the amount of lightand integration of IP services via PLC.- Urban mobility: sus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Microalgae cultivation in a WRRF scheme to improve circularity and risk-based assurance in wastewater treatment using digital tools.' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

MicroAlgae 4.0 will allow the researcher to improve his knowledge and skills in the application of Circular Economy, digitalisation, water-energy-food-ecosystems Nexus, and the zero-pollution ambition to the water treatment sector. This project will be carried out at the Polytechnic University of Marche (UNIVPM) (Italy) under the supervision of Prof. Francesco Fatone. UNIVPM appears as an ideal Host to coordinate this project due to their vast experience in developing EU-funded projects, including DWC (www.digital-water.city), FIT4REUSE (https://fit4reuse.org), and PROMISCES, which are in line with some of the activities developed in MicroAlgae 4.0. As part of this project, the researcher will develop a Secondment at the Polytechnic University of Valencia (UPV) (Spain) and a short visit in SIMAM S.p.A. (Italy). MicroAlgae 4.0 combines aspects related to environmental science, chemical engineering, microalgae biology, human health, computer science, legislation and social aspects, with the goal to develop a Water Resource and Recovery Facility (WRRF) scheme based on microalgae cultivation biotechnology to maximise reclaimed water production and nutrient recovery from wastewater and to minimise environmental pollution. To this aim, MicroAlgae 4.0 will focus on overcoming the barriers that hinder the wide implementation of microalgae-based systems by improving the performance and reliability of the process, developing innovative digital tools that monitor and automate the system, and assuring the safety of the by-products obtained. MicroAlgae 4.0 will also allow improving researcher´s skills such as teamwork, leadership, digital skills, communication, innovative thinking, proposal writing and development of products and processes. This will make him a proficient researcher
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The mechanisms that underlie the development of a tendon-bone attachment unit' (TENDONTOBONE) under Seventh Framework.

assistant: **Objectives**

We walk, run and jump using the complex and ingenious musculoskeletal system. It is therefore puzzling that although each of its components has been extensively studied, research of the musculoskeleton as an integrated system and, in particular, of its assembly has been scarce. In recent years, studies conducted in my lab have demonstrated the centrality of cross regulation between musculoskeletal tissues in skeletogenesis. These works have provided me with the inspiration for a revolutionary hypothesis on the way tendons connect to bones, along with sufficient preliminary data on which to base it.The critical component in the assembly of the musculoskeleton is the formation of an attachment unit, where a tendon is inserted into a bone. Instead of two tissues that attach to each other, my novel hypothesis suggests that the entire attachment unit originates from a single pool of progenitor cells, which following differentiation diverges to form a tendon attached to cartilage.With the support of the ERC scheme, I will uncover the previously uncharacterized cellular origin of the attachment unit and the genetic program underlying its development. The attachment unit is a compound tissue, as it is composed of chondrocytes at one end and of tenocytes at the other end. We will investigate the mechanisms that facilitate in situ differentiation of mesenchymal progenitor cells into two distinct cell fates, under one defined niche. In addition, I will identify the contribution of both mechanical stimuli and molecular signals to the development of the attachment unit.The ultimate goal of this program is to provide a complete picture of attachment unit development, in order to promote understanding of musculoskeletal assembly. The acquired knowledge may provide the basis for new th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A MOSAIC OF ESSENTIAL ELECTRONIC COMPONENTS AND SYSTEMS (ECS) FOR OUR AUTOMATED DIGITAL FUTURE IN INDUSTRY AND MOBILITY' (ECS) targeting Horizon Europe.

assistant: **Abstract**

MOSAIC addresses a grand challenge for European competitiveness: technological independence and filled fabs in the landscape of automated systems. By fostering innovation in Electronic Components and Systems (ECS), MOSAIC aims to propel Europe to excellence and digital autonomy, directly linked to the EU Chips Act.The project achieves this through a comprehensive strategy. It will develop next-generation ECS offering superior, cognitive system intelligence, enabling energy efficiency and robustness. These results will be tailored to the demands of automated systems, enabling rapid data processing and intuitive, AI-enabled decision- making.MOSAIC tackles the challenge of integrating diverse perception hardware configurations, ensuring that automated systems can perceive their surroundings in a non-invasive manner, avoiding a single point of failure, with unparalleled accuracy and decreased complexity. Additionally, the project emphasizes standardized communication protocols and interoperability, fostering a collaborative ecosystem across several industries, namely automotive, aerospace, maritime, industrial automation and infrastructures. By spearheading such advancements, MOSAIC empowers European ECS manufacturers to gain a competitive advantage.The project's achievements will be demonstrated in 31 cutting-edge technical showcases, indicatively global perception through 360° distributed radar, AI-enabled reasoning through magnetic field signature and resilient communications by means of non-terrestrial networks. 2 accompanying impact studies, will solidify Europe's position as a global leader in automated systems.MOSAIC leverages a pan-European consortium encompassing the entire ECS value chain, ensuring a comprehensive effort towards filling the European fabs and ensur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Mechanism of Synovial Joint Lubrication' in the context of a Seventh Framework call.

assistant: **Objectives**

This application is concerned with the study of the molecular basis of skeletal joint lubrication in order to improve the design of artificial joint prostheses. These joints eventually fail mainly because of problems associated with inadequate lubrication and revision surgery is an increasingly expensive burden as the population ages. A better understating of such processes should lead to better strategies for minimizing lubrication breakdown in natural joints, as well as to strategies for improving lubrication and wear of prosthetic joint implants and other biological surfaces where prevention of adhesion is required. This proposal seeks to investigate the molecular basis of the remarkably efficient lubrication in mammalian synovial joints, by constructing surfaces partly analogous in structure to that of articular cartilage and measuring forces between them under strictly controlled conditions. Using a surface force balance apparatus, we intend to measure the normal and friction forces between layers of (i) negatively charged hyaluronic acid (HA)-aggrecan (ii) lubricin and HA-aggrecan and (iii) HA-aggrecan and phosphatidylcholine-based phospholipids (PL). Firstly, a pre-biotynilated HA will be attached to mica surface via streptavidin. Aggrecan, extracted from mammalian cartilage, will be added to the HA-coated mica to form supramolecular aggregates similar to those at the cartilage/synovium interface. Secondly, a well-characterized lubricin layers and in a later stage fluorescent or radio-labeled PL will be adsorbed onto the HA-aggrecan mica surface and the interactions studied. Our ultimate goal is to address the interactions between lubricin, PL and HA – the main players in synovial lubrication. At each stage of the project, mica-attached layers will be characteriz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced SIgnal processing schemes for Link capacity increase in UMTS', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The current specification of the air interface of UMTS focuses on the use of conventional transceiver algorithms including single antennas at both the base station and at mobile terminals for bitrate up to 2 Mbit/s. However, performances are drastically limited by the multiple access interference. The objective of the ASILUM project is to validate new transceivers concepts, for both base station and mobile terminal, to increase the capacity of the future generation of UMTS through new and efficient interference mitigation schemes. These techniques will be optimally combined to provide innovative improved interference mitigation schemes together with high hardware efficiency. A software-based simulation platform running a number of competitive techniques will be designed, implemented and validated. During all the life of the project, inputs from standardisation bodies will be carefully analysed and at the end of the project, a set of recommendations will be made to standardisation organisms.Objectives:A major goal of the ASILUM project is to propose new efficient combinations of interference mitigation techniques taking into account the trade-offs of the various techniques trying to optimise in terms of implementation costs. A simulation platform will be developed and used to assess the performances of the interference mitigation schemes, both at the link and system levels. These simulations will be conducted by taking into account a wideband directional channel model and some hardware implementation constraints. A fair comparison of the alternative schemes will be done in terms of maximisation of capacity of UMTS, in both FDD and TDD modes, versus their implementation complexity. During all the life of the project, inputs from standardisation bodies will be carefully an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Moving healing plants: Epidemic histories and networks of care along the Amazon river' under Horizon Europe.

assistant: **Concept**

Epidemics involve the circulation not only of pathogens, animals and people, but also of healing plants. In a highly innovative approach, MovingHealingPlants explores human-plant-pathogen networks of care emerging in the exchange of healing plants used for epidemic diseases. The project engages a longue durée timeframe from colonial encounters to current urbanisation processes in Amazonia, and extends along the Amazon river axis connecting contemporary Amazonian cities of Manaus (Brazil), Leticia (Colombia) and Iquitos (Peru). With its headwaters in the Andes and flowing into the Atlantic coast, the highly navigated and populated Amazon river has been decisive in the history of medicine and public health in Amazonia and South America. Yet so far, historical accounts are fragmented into colonial or contemporary nation-states borders, or focus on specific diseases or institutions. This groundbreaking project proposes an interconnected fluvial account of the history of medicine and intercultural relationships of care, from the vantage point of the circulation and transformations of healing plants. Drawing from ethnobotany, global health, history, STS and anthropology, this project aims to assemble a history of epidemics and intercultural care in Amazonia, to explore cosmologies and technologies of plant transformations through ethnographic collaborative participatory approaches, and to produce a critical account of emergent networks and boundary dynamics in a field of Amazonian health simultaneously global and locally situated. MovingHealingPlants highlights the relationships Amazonian Indigenous people form with healing plants as persons, in a more-than-human cosmopolitics from where to rethink some of our most pressing anthropocenic predicaments: environmental destructio