RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantum lock-in amplifier phonon detectors' to be submitted under Horizon Europe.

assistant: **Abstract**

The precise measurement of phononic properties of materials is crucial for the emerging physics and next-generation technologies. With the ever-growing study of phononic many-body physics, the need for precise phonon measurement has become increasingly important. Quantum lock-in measurement techniques offer a promising avenue for future phonon detection, boasting significant advantages such as ultra-high resolution, heightened sensitivity, and the capability for concurrent measurement of amplitude, frequency, and phase.In this project, I propose innovative quantum lock-in amplifier phonon detector (Q-LAMP) for phonon detection for the first time and plan to experimentally demonstrate their effectiveness in simultaneously measuring phonon phase, frequency, and amplitude. I plan to use Q-LAMP to measure topological localized states in phononic crystals and can also be employed for detecting weak microwaves. The quantum lock-in amplifier developed in this project will pushing both phononics physics and wireless communication to new stage.This interdisciplinary training scheme is designed to enhance Ruihuan's expertise in quantum optics, fortifying his skills and helping him establish a research career in Europe. It covers component design and implementation, theoretical analysis, mathematical modelling and applications. To assist Ruihuan in attaining professional maturity and broadening his exposure to academic and industrial collaborations, he will receive training on intellectual property management, funding and proposal writing, commercialization, supervision and teaching. Secondment in academic host, with Prof. Martijn Wubs (DTU, Denmark) is arranged to pursue scientific objectives, enriching Ruihuan's learning experience, expanding his network in Europe and maximizing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Renewable Energies for Water Treatment and REuse in Mining Industries'.

assistant: **Objectives**

The overall aim of REMIND is to develop an innovative framework of interplay between Renewable Energy Sources (RES) and innovative Water Treatment Technologies in the logic of a sustainable growth for mining industries. The novel paradigms explored are expected to drastically reduce the environmental impact due to extensive water and energy consumption, and to release of untreated wastewater during the production cycle of copper and gold. The REMIND collaborative network among European Union, Chile and Ecuador is in line with EU policy and strategy for raw materials supply; moreover, this partnership supports the economic and research efforts of Latin American countries towards a more eco-friendly and RES-driven development.The bi-directional knowledge transfer activities implemented in REMIND aim to: i) implement a rational use of water resources in the logic of circular economy; ii)  promote a carbon-free technological approach (water-energy nexus)  for reducing conventional energy resources requirements, and iii) mitigate health environmental risk in two demonstration sites (mining districts of Antofagasta – CL and Regione de l’Oro – EC), and iv) exploit the intersectorial cooperation between academia and industry by setting best practices for knowledge transfer in analogous contexts.REMIND brings together 7 leading High Education Institutions, 1 Research Institute, 1 Business Association and 3 Industrial Companies from 5 Countries (Italy, Spain, Sweden, Chile and Ecuador), and implements a multisectorial and transdisciplinary network.


**Keywords:** membrane science and technology,  renewable energy sources
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Strengthening Clinical Trial Regulatory and Ethical review Oversight in East Africa'.

assistant: **Concept**

There is an increase in the number of drug development clinical trials conducted in Sub-Saharan Africa (SSA), including vaccine development studies for poverty-related diseases (PRDs) underway in SSA. These increases have not been matched with increase in regulatory support and ethical review for such studies in SSA. Specific gaps exist in skills and knowledge in providing adequate regulatory oversight, ethical review and pharmacovigilance for such studies, efficiency of the regulatory and ethical review processes. With sequential processes of review requiring a prolonged period before approvals are granted, there is dissatisfaction with the the time interval from submission to decision, within the research community.  Additionally, mechanisms for reporting adverse events to both the ethics committees and national regulators are not well developed. The Aim of AccessAfrica 2 is to improve ethical review and regulatory capacity for clinical trials in two Sub-Saharan Africa (SSA) countries, with specific focus on the review and oversight of reported adverse events during clinical trials, improve efficiencies of the NECs and NRAs, and equip them with skills and knowledge for oversight for novel research designs.AccessAfrica 2 is a embedded in the Eastern Africa Consortium for Clinical Research  (EACCR), and EDCT funded network, and is continuation of AccessAfrica project which was funded by EDCTP. We propose to address the identified gaps through the three objectives and four work packages.  We will establish a consensus driven consortium with partners leveraging each others strength to achieve the objectives. We propose to incorporate the AVAREF guidelines in the regulatory and ethical review guidelines of the partners, and work with the Kenya Pharmacy and Poisons board to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Atomic functionalities on silicon devices' (AFSID).

assistant: **Innovation**

In this project, we wish to take advantage of a fundamental figure-of-merit of the CMOS transistors, the doping modulation, to propose new functionalities arising from the control of a single charge and spin on individual dopants in silicon. <br/>The ultimate electrical switch is an atomic point contact. It has been realized and operated several times in laboratories at low temperature under the form of Quantum Point Contacts (QPC), metallic break junctions, molecules placed in an air gap. However a silicon atomic switch has not been realized yet. The devices will be manufactured within a mature technology on state-of-the-art CMOS platforms.  <br/>Contrarily to bottom-up approaches, there is an unavoidable dispersion in the average number and location of dopants, using masking and implantation CMOS techniques. Nevertheless several approaches are now addressing this question for top-down devices, and this option will be considered. Therefore, we will study single atomic devices, either real (i.e. dopant) or artificial (i.e. quantum dots), with a manageable dispersion by considering three generic cases: devices without dopant, devices with a targeted concentration of one dopant and devices with many dopants. <br/>Devices without dopant will be based on ultimate silicon SET. A targeted size of 10 nm is realistic, allowing operation at low temperature (but much above 4.2K). These devices are fully controlled and scalable. <br/>Devices with one dopant or two dopants will be identified and selected from their electrical characteristics and then studied thoroughly. Relatively high operating temperatures up to room temperature are expected using donors with large ionization energy. These devices are the smallest possible switches using the silicon technology.  <br/>Because our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Seasonal activity of Polar Dunes on Mars' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A significant finding of the data analysis from the High Resolution Imaging Science Experiment (HiRISE) on board the Mars Reconnaissance Orbiter is the confirmation of active surface processes under the current Martian climate. Many of these processes in the Polar Regions are linked to seasonal volatile and wind cycles, such as the migration of aeolian ripples and sand dunes, avalanches of carbon dioxide ice from polar cliffs and formation of new dune gullies and alcoves. The proposed research will quantify the geomorphic work of active surface aeolian process on annual timescales. We aim to constrain the rate, timing and volume of sediment transport by ripple and dune migration and by the newly identified cryo-venting process. Our work will focus on dunefield sites in the circumpolar region that reflect the range of latitudes, topographies, and dune morphologies. We will use HiRISE images, now available for three Mars years, to determine the migration rate of dunes and ripples.  DTM models of dune fields will be used to characterize dune form, slopes and volume, from which bulk sediment transport will be estimated. High temporal resolution images will identify springtime wind direction variability in a novel use of cryo-venting fan deposits as wind vanes. The timing of seasonal ripple migration and seasonal ice sublimation will be constrained and locations of remnant ice patches on dunes identified. The recovery of changes in dune slipface morphology from cryo-aeolian and aeolian process will be assessed and relative sediment volume transport will be estimated from DTM’s. These combined analyses will advance our understanding of duneform evolution and move towards defining the aeolian system sediment state on Mars
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PI3K delta role in dendritic cell antigen processing and presentation to control gut tolerance' (PI3K-in-tolerance).

assistant: **Concept**

PI3Ks controls important biological processes immunity controlling vesicular trafficking and cell signaling events triggered by pathogen recognition receptors (PRRs). The engagement of PRRs leading to DC antigen processing and presentation (APP) is essential for the bridge between innate and adaptive immunity.  Thus, DCs are crucial for resistance against pathogens, while concurrently maintaining tolerance to the commensal microbiota and environmental antigens. Crohn’s disease (CD)-like pathology has been documented in patients with chronic granulomatous disease (CGD), originating from mutations in genes encoding NADPH oxidase (NOX2) subunits or RAC2 GTPase. Both PRR-activated NOX2 and RAC2 are critical for inducing phagosomal reactive oxygen species (ROS) linked to APP processes in the DC. Thus, that dysregulated PRR signalling and NOX2 activity in the DC phagosome, may be key steps involved in some of the pathology observed in CD. The PRR family member NOD2 senses muramyl dipeptide in bacteria. NOD2 was the first susceptibility gene identified for CD and associated with tolerance mechanisms mediating intestinal homeostasis to gut microbiota. Recently, interactions between NOD2 and microbiome were shown to stimulate Treg activity at the mucosal sites. Bacteria-derived outer membrane vesicles (OMVs) from gut commensal Bacteriodes fragilis induce mucosal tolerance by DC-intrinsic activation of NOD2 and enabling DCs to induce IL10 production from Tregs. It is known that OMVs require NOX2-induced ROS to be released for APP and presented by MHCII to activate CD4 Tregs. Our preliminary data shows that mice inactivated in the kinase domain of PI3K delta spontaneously develop colitis in the presence of an intestinal opportunistic pathogens and show defects in antigen presentat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel algorithm for treatment planning of patients with osteoarthritis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Osteoarthritis (OA) is a common joint disease affecting over 40 million Europeans. Most common consequences of OA are pain, disability and social isolation. What is alarming, the number of patients will increase 50% in developed countries during the next 20 years. Moreover, the economic costs of OA are considerable since 1) direct healthcare (hospital admissions, medical examinations, drug therapy, etc.) and 2) productivity costs due to reduced performance while at work and absence from work have been estimated to be between 1% and 2.5% of the gross domestic product (GDP) in Western countries.We have developed an algorithm that is able to predict the progression of OA for overweight subjects while healthy subjects do not develop OA. When employed in clinical use, preventive and personalised treatments can be started before clinically significant symptoms are observed. This marks a major breakthrough in improving the life quality of OA patients and patients prone to OA. Our discovery will directly lead to longer working careers and lesser absence from work, and will result subsequently increased productivity. Moreover, the patients are expected to live longer due to reduced disability and social isolation.Moreover, the discovery provides economic long-term relief for the health care system, which is burdened by increasing geriatric population and stringent economic environment. With our tool, as an example, by eliminating 25% of medical examinations annually due to overweight or obesity in Finland (150.000 patients), we estimate to decrease annual direct costs by 140M€ and indirect costs by 185M€. In the PoC project we will carry out technical proof-of-concept and perform pre-commercialisation actions to shorten the time to market. The ultimate goal after the project is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Non-Thermal physical technologies to preserve healthiness of fresh and minimally processed fruit and vegetables'.

assistant: **Innovation**

SHEALTHY proposal aims to assess and develop an optimal combination of non-thermal sanitization, preservation and stabilization methods to improve the safety (inactivation of pathogens and spoilage microorganisms), while preserving the nutritional quality (up to 30%) and prolonging the shelf-life (up to 50%) of minimally processed F&V products. By combining and modulating non-thermal technologies with minimally processing operation, we will respond to consumers’ demand for fresh, healthy, convenient, sustainable and locally produced and additive-free food. The combined and optimised mild technologies will be demonstrated and validated in 2 business cases: Minimally processed fruits and vegetables and Fruit and vegetable-based juices & smoothies. Sanitization during washing will be optimized by applying in combination ultrasound (US), electrolysed water, plasma activated water, High Intensity Pulsed Light and Blue Light. Bioactive coating, active and intelligent packaging will be applied for quality preservation and shelf life extension of minimally processed F&V. F&V-based juices & smoothies will be stabilized by US and high pressure processing. For F&V by-product valorisation, US, pulsed electric field and membrane filtration will be used to extract bioactive compounds.Sustainable and flexible processing methods will be transferred and adapted to the need of local F&V micro and SMEs, interconnecting primary producers through novel cooperative business models and new logistics systems, to enhance the traceability and authenticity of raw materials along the F&V value chain. Commercial feasibility will be assessed, including consumer acceptance and regulatory, safety and environmental aspects. SHEALTHY will combine the technology trends and consumer needs to afford the bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Construction of Perception from Touch Signals' to be submitted under Seventh Framework.

assistant: **Abstract**

Our sensory systems gather stimuli as elemental physical features yet we perceive a world made up of familiar objects, not wavelengths or vibrations. Perception occurs when the neuronal representation of physical parameters is transformed into the neuronal representation of meaningful objects. How does this recoding occur? An ideal platform for the inquiry is the rat whisker sensory system: it produces fast and accurate judgments of complex stimuli, yet can be broken down into accessible neuronal mechanisms. CONCEPT will examine the process that begins with whisker motion and ends with perception of the contacted object. Understanding the general principles for the construction of perception will help explain why we experience the world as we do.The main hypothesis is that graded neuronal representations at early processing stages are “fractured” to generate discrete object representations at late processing stages. Of particular interest is the emergence of object representations as the meaning of new stimuli is acquired.We will collect multi-site single-unit and local field potential signals simultaneously with precise behavioral indices, and will interpret data through advanced computational methods. We will begin by quantifying whisker motion as rats discriminate texture, thus defining the raw material on which the brain operates. Next, we will characterize the transformation of texture along an intracortical stream from sensory areas (where we expect that neurons encode whisker kinematics) to frontal and rhinal areas (where we expect that neurons encode objects extracted from the graded physical continuum) and hippocampus (where we expect that neurons encode objects in conjunction with context). We will test candidate processing schemes by manipulating perception o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterisation of hybrid inorganic-organic solar cells by advanced spectroscopic methods' (CHOIS).

assistant: **Innovation**

The displacement of CO2 emissions by renewable sources of energy critically depends upon the development of low-cost and widely accessible routes to clean energy generation. Of all the renewable energy sources, solar energy has the greatest potential as a world power source. However, the inorganic solar cells available on the market now are too expensive to compete with conventional power sources. Hybrid solar cells are an emerging solar cell technology with a great potential for cheap fabrication. They usually consist of a nanostructured junction of inorganic and organic semiconductors and therefore combine cheap and abundant organic materials with the advantages of inorganic materials in terms of stability and charge transport. Power conversion efficiencies exceeding 3 % have been obtained and there is a large potential for further efficiency improvements. In order to achieve these, a detailed understanding of the working mechanism of hybrid solar cells is of crucial importance. In this project, we therefore aim to carry out an in-depth characterization of hybrid solar cells using a variety of advanced spectroscopic and microscopic techniques and a multidisciplinary approach. The project will consist of three phases: In the first phase, a state-of-the-art hybrid CdS/polymer system will be characterised in order to gain a better understanding of the working mechanism of the solar cells. Following this, hybrid solar cells consisting of different materials and prepared by different methods will be compared and loss processes in the solar cells will be identified. In the final phase of the project, the gained knowledge will be used to propose new materials combinations, which will lead to the construction of more efficient hybrid solar cells. The proposed project will the