RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Sustainable Algal Fucoxanthin Extraction, Encapsulation and Valorisation Using Hydrodynamic Cavitation (SAFE)'.

assistant: **Objectives**

Title: Sustainable Algal Fucoxanthin Extraction, Encapsulation and Valorisation Using Hydrodynamic Cavitation (SAFE).Marine algae act as carbon sinks, utilizing carbon dioxide for their growth and metabolism. Channelising these marine biomasses will result in the production of sustainable and valuable metabolites with wide range of applications in food, nutrition, pharmaceutical, and cosmetics sectors. This can also contribute to achieving Europe's Net Zero goals by 2050. The SAFE project introduces an innovative and sustainable process for extracting Fucoxanthin, an orange coloured pigment present in marine brown algae, which offers a sustainable alternative to synthetic colorant Sunset Yellow FCF. Synthetic colours are reported to cause hormonal imbalance and cancer in humans. Fucoxanthin is not only a safer option but also offers potential health benefits. In the global market, fucoxanthin demand is valued at 2.1 billion USD in 2023 and is projected to increase to 3.15 billion USD at a CAGR of 5.2% by 2032. Extracting fucoxanthin from brown algae is however challenging due to the cell wall rigidity, which makes the process energy-intensive. SAFE aims to achieve a step change in fucoxanthin extraction using a novel vortex based hydrodynamic cavitation process by overcoming this limitation. Additionally, fucoxanthin is sensitive to light, temperature and pH, necessitating enhanced stability measures. To improve stability of fucoxanthin, heat-resistant nanoliposome encapsulation is also proposed. Furthermore, in line with the principles of circular economy, the residual biomass from the process will be utilised for the production of biomethane to demonstrate the overall valorisation potential of the marine algae. This strategic research initiative in algal biotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional genomics of complex regulatory networks from yeast to human: cross-talk of sterol homeostasis and drug metabolism' (STEROLTALK), addressing dissemination and exploitation.

assistant: **Impact**

The vision of STEROLTALK is to develop a global approach by combining dedicated functional genomic tools, three model organisms and in silico modelling, for the discovery of new drugs targets, new chemical entities and therapeutic strategies. Regulatory networks in human, mouse and S. cerevisiae will be assessed through integrative analysis of transcriptome, proteome, metabolome and by yeast engineering. This will allow for the first time to dechipher the multi-level response of cholesterol homeostasis to known and candidate drugs, and its modulation in pathologies. Typical investigation targets will be animal and adult human livers and primary hepatocytes. The first task of our STREP is to develop original tools for functional genomic analyses of drug-modulated responses of STEROLTALK genes, proteins and metabolites in biological models. Tools include a dedicated microarray, antibody set, siRNA knockouts, humanized yeast and database. Deposited analytical data will be evaluated by numerous bioinformatic approaches, to assist in building relevant in silico models with predictive values, ready for implementation in novel drug discovery strategies. In silico model prediction will allow for the first time to identify potential cholesterol homeostasis-related targets that will be validated in vivo in biological models by the original STEROLTALK tools. This will eventually lead to substantial breakthroughs with numerous applications in the fields of drug discovery, development of diagnostic procedures, providing also new tools for pharmacological interventions. The project features multiple functional genomics challenges. In tackling these, it will lead to breakthroughs in functional genomics tools development and will drastically advance our understanding of the cross talk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Continuous on-line atmospheric pressure plasma equipment based on dielectric barrier discharge technology for surface processing of various papers & textiles, fibres for composites and plastics' under Fifth Framework.

assistant: **Concept**

The aim of the project is to develop a continuous on-line atmospheric plasma process (speed 600 m/min; width of treatment 1-2m) for the surface treatment of various materials (papers, fibres, plastics, textiles). The objectives are to obtain better products (adhesion, wettability, inkability, etc.), to improve process outcome, consume less energy and harmful chemicals, reduce contamination on the final products and environmental burden, reduce waste to dispose. The consortium is composed of 12 partners from 6 European nationalities. 6 research centres (3 are specialised in Plasma, 1 in paper, 1 in composite fibres, 1 in material sterilisation) and 6 industrials (1 manufacturer of plasma equipments, 1 paper producer, 1 glass fibre producer, 3 textile manufacturers).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EC decommissioning information network' (EC-DB-NET2).

assistant: **Innovation**

Within the 4th EC framework programme Nuclear Fission Safety" two databases have been further developed providing detailed information on dismantling, recycling and decontamination techniques and tools (FI4D-CT95-0004) as well as data on costsand dose rates (FI4D-CT95-0003). Within the project FI4D-CT96-0010 possible network implementations to access both databases via Internet were investigated and implemented and a web site on the European activities in the field of decommissioning with the main purpose to give the public an understanding of this subject was developed. Within EC-DB-NET2 the databases EC-DB-COST and TOOL as well as the Decommissioning Web Site shall be maintained, updated and further developed as an essential part of a sustainable European decommissioning information network based on information technology which aims at combining the operational experience and know-how needed for a safe and reliable future decommissioning."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Novel tools to evaluate ATM systems coupling under future deployment scenarios'.

assistant: **Innovation**

The primary objective of Domino is to develop a set of tools, a methodology and a platform to assess the coupling of ATM systems from a flight and a passenger perspective. The platform will allow ATM system designers to gain insight on the impact of applying new mechanisms. It will provide a view of the impact of deploying solutions in different manners, e.g., harmonized vs. local/independent deployment, and information on the criticality of elements in the system and how this might be different for different stakeholders.Domino will identify, test and validate metrics based on complexity science to understand the coupling of elements in the ATM systems, creating at toolbox to analyse the system. A generalizable and extendable agent-based model, capable of capturing the interactions between stakeholders and ATM elements, will be developed. Behavioural models will be created to capture the impact of modifying the operational context by introducing new mechanisms.Domino will define a set of case studies to test the methodology based on a few mechanisms: Dynamic Cost Indexing (DCI), User-Driven Prioritisation Process (UDPP) and Extended Arrival Manager (E-AMAN). These mechanisms will be modelled with different operational concepts and uptakes and in isolation or in conjunction.Two set of case studies will be used: investigative and adaptive. Investigative case studies will be defined early in the project and prioritised with a stakeholders’ consultation. The results of those investigative case studies along with potential modifications to mitigate or enhance some of the effects observed will be presented at a dedicated workshop. The output of that workshop with stakeholders will be the adaptive case studies, which will be tested in their turn.A key element of Domino is the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'COvariance Based RAman Spectrometer (COBRAS)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In COBRAS we will establish Femtosecond Covariance Spectroscopy, a new spectroscopic technique to measure the optical response of material which is based on stochastic light pulses characterized by frequency uncorrelated intensity fluctuation. By using light with different property every repetition, each reiteration of the experiment can be considered as a measurement under new conditions rather than a repetition of the same experiment. Crucially, within the ERC_StG project INCEPT we have demonstrated that in this limit the frequency of the Raman modes of a sample can be retrieved by measuring the spectral correlations in different pulses which are induced by the interaction with the sample. This is in striking contrast with standard approaches to Raman spectroscopy which are based on the measurement of the integrated emission of Raman sidebands at a given frequency and therefore require a high stability and low noise detection which can be reached only at a significant expense. Conversely, in covariance-based methods noise is a resource that can be exploited (rather than an impediment) and a much simpler and cheaper architecture for the spectrometer can be envisioned.The central idea of COBRAS is to set the way for commercial exploitation of covariance-based approaches to Raman spectroscopy. To this purpose we will develop a prototype spectrometer, study the general applicability of the covariance based methods and identify viable strategies for the commercialization of the spectrometer developed. We stress that the concept proposed here for Raman spectroscopy can be extended to different optical techniques and wavelength ranges. This make us confident that the COBRAS investment may represent a paradigmatic change in the approach to optical spectroscopy, potentially di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Proglacial and subglacial aquifers: their evolution under climate change and the potential impacts in terms of resources and natural hazards, through the case of eastern Iceland'.

assistant: **Concept**

The research addressing glacier evolution under climate change is well developed, looking not only at changes in mass balance, but also at the associated effects on basal and downstream hydrology. However, aftermath changes to the groundwater component are rarely considered, even though evolving groundwater recharge, discharge and storage will be required to forecast the evolution of water resources and of water-related hazards under climate change. This knowledge gap is the object of IceAq.IceAq will focus on 4 outlet glaciers of the Vatnajökull, the main icelandic icecap, which retreat under climate change is already documented. In addition to gathering of existing data (from geology to climatology), new data will be acquired on the field, mainly to characterise groundwater. Based on those data-sets, local comprehensive numerical models will be build, and then be integrated into a regional one, which will allow more realistic hydrogeological simulations, and the input of future climate scenarios.The scientific perspective is threefold: achievement of an operational understanding and quantification of unknown or poorly known aquifer systems in glacial context, prediction of their hydrodynamic response to climate change, and exploration of the potential role of glacier-aquifer interactions in the mechanism of deep recharge and formation of offshore fresh groundwater stocks in littoral zones.Outputs of the project will provide first answers to those interrogations, and be disseminated in the scientific community but also to the general audience through a participatory approach. The developed methodology will be applied in the future to other glaciated systems in different contexts.Dr Vincent and the glaciology group of IES, UoI, have very complementary expertise, essenti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Elucidating the role of macrophages in liver regeneration and tissue unit formation' (LiverMacRegenCircuit), addressing dissemination and exploitation.

assistant: **Impact**

The liver, unlike many other tissues, has the ability to rapidly regenerate and restore function following tissue damage or surgical resection. This regenerative capacity has been recognized as far back as the ancient Greeks, who described it in the myth of Prometheus. Despite this, the precise molecular and cellular mechanisms underpinning the regeneration process are yet to be fully elucidated. Macrophages (Macs) have been proposed to play a role in regeneration but it has not been clear if these are Kupffer cells (KCs), the tissue resident macs of the liver, or macs recruited during the regeneration process (rMacs). Previously available tools have not allowed a distinction to be drawn between these cells. Within the liver KCs and/or rMacs are in close proximity to hepatocytes, hepatic stellate cells (HSC) and particularly liver sinusoidal endothelial cells (LSECs), these cells together with liver macrophages can be thought of as a tissue unit, which needs to be rebuilt as the liver regenerates. Adopting this tissue unit view of the liver, we hypothesize that these cells interact with one another forming a stable circuit, the maintenance of which is required for normal liver regeneration. Here we propose the use of novel and innovative tools including KC and tissue unit cell-specific knock in mice to study cell-cell cross-talk and conclusively determine the cell-circuit signals driving the formation of new functional units within the liver. With donor organs in short supply this project has the potential to uncover pro-regenerative therapies that are so desperately needed.


**Keywords:** Macrophage, Kupffer cell, liver regeneration, cell-cell interaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Recycling waste tyres into devulcanized rubber' (RETYRE).

assistant: **Innovation**

Gumos Technologijos (GT) has developed a full-cycle waste rubber production line, based on a patented mechano-chemical technology for rubber devulcanization that ensures a high quality of the product and improved performance as raw material. By combining an existing technology for rubber recycling (i.e. devulcanization with ozone treatment) with a unique mechano-chemical method (using a patented chemical agent), waste tyres will be converted into higher value products than those obtained with current solutions on an industrial scale. The market for waste tyres is tightly connected with the production of new tyre as eventually all the produced tyres need to be reclaimed. The tyre industry uses by 70% of all the natural rubber and estimates for the next 30 years predict that the consumption will double. This could mean that the availability of raw materials such as natural and synthetic rubbers may become problematic. Despite being Europe the second largest virgin rubber consumer in the world (with a tyre production estimated at 20% of the world production), EU has not established its own alternative for rubber materials recycling and production, being dependent on supply from South East Asia.RETYRE will increase the value of End-of-Life Tyres (ELTs) by improving the recycling efficiency and producing as output a high-value devulcanized rubber. This recycling option will increase EU´s global competitiveness and innovativeness by improving European recyclers’ market position and decreasing EU´s dependency on raw rubber materials.The unique selling points of RETYRE will be: (1) Lower equipment costs and operational costs, with 50% less energy consumption and equipment maintenance; (2) Full-cycle production units, recycling ELTs from tyres to crumbs, metals, fibre and devulc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nanoscale solid-state spin systems in emerging quantum technologies'.

assistant: **Innovation**

This network brings together world-leading experts in nano-science and technology from 6 European countries in order to achieve breakthroughs in understanding and successful utilization of nanoscale solid-state spin systems in emerging quantum technologies. The proposed innovative science in the supra-disciplinary field of physics and applications of spin nano-systems will underpin breakthrough developments in quantum computing, quantum communications and networks, and nano-imaging. Important innovative step consolidating the joint effort of the whole consortium is the focus on crystalline solids where magnetic interactions of electron spins with lattice nuclei are negligible and well-controlled. We will develop electrically-controlled spin-quantum-bits (qubits) in Si-Ge quantum dots and nanowires; will optically manipulate spin impurities in diamond in applications for quantum computing and networks and in nano-magnetometry; will achieve new understanding of quantum phenomena due to the spin-valley coupling in atomically thin 2D semiconductors, an emerging class of materials with a promise for quantum technologies. Research training to 15 early stage researchers will be delivered by 14 academic and 7 industrial groups. Network-wide training course in transferable skills will be specially developed and delivered by the Think Ahead (Sheffield), an award winning initiative at the University of Sheffield (award by the Times Higher Education, 2014). Current proposal is designed to advance this multi-disciplinary research field significantly beyond the state-of-the-art, and train a new cohort of researchers capable of developing spin-based solid-state quantum technologies towards real-life applications in the next 5 to 10 years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Logistics-based design (LOGBASED)' under Sixth Framework.

assistant: **Concept**

The LOGBASED project aims at developing more efficient ro-ro vessels as an integral part of developing and operating more effective intermodal transport value chains. Currently, vessel performance evaluations are normally limited to the isolated vessels' performance. Seldom, is the overall performance of the logistics value chain assessed and benchmarked with the vessels' performance included. The aim of this project is, therefore, to develop a specific logistics-based design process with an opportunity to assess the performance of transport value chains with the vessel performance as an integral part of this assessment. Thus, more efficient vessels' solutions can be developed in the future so that these may be used for the displacement of long-haul road freight and for opening up new intermodal corridors. The new advised design and assessment approach should particularly be capable of guiding a consistent and streamlined design process of the maritime solutions of a transport value chains. In this way, can the overall theoretical, logistic solution's performance be assessed and benchmarked at the design stage, including but not limiting to the vessels performance. It is a separate goal of this project when applying this new logistics-based design approach to improve efficiency of the vessel's performance with up to 30% (fuel economy, building costs, environmental impact, stability, payload, weight/volume, manoeuvrability and turn around time in port).