RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Applying energy efficient measures for metal and metalworking SMEs and industry'.

assistant: **Innovation**

EE-METAL aims to provide enterprises with innovative technical, commercial and financial tools in order to overcome the existing barriers that hinder the adoption of energy saving measures. EE-METAL actions are mainly targeted to Metalworking and Metal Articles (MMA) SMEs, given that this sector is the biggest manufacturing sector in Europe and it is mostly composed by SMEs. EE-METAL actions will focus on overcoming: Awareness, information and technical capacity barriers to identify, evaluate and implement energy efficiency actions: EE-METAL will adapt and standardize for the sector existing methods and technologies such as energy audits, the standard ISO 50.001 and the use of Energy Monitoring Systems.Commercial and market barriers to the contracting of energy service companies (ESCos): development of a benchmarking study of energy service contracts and the role of ESCOs in the MMA and other industrial sectors; networking with ESCOs Associations for fostering ESCOs-SMEs contracts.Financial barriers to the implementation of energy saving measures: benchmarking the different financial models being implemented in the partner countries for financing energy saving institutions for providing clear information on type and size of investments needed.These two last actions will allow put in place mechanisms for funding the energy efficiency projects identified in the first action. In this sector, big energy savings can be obtained by the aggregation of many smaller savings.Furthermore five out of the seven project partners are Enterprise/Trade Associations (with 7000 associated companies) that will ensure that a critical mass is achieved.EE-METAL is in line with the following EU strategies and initiatives: first priority of the EU Energy 2020 Strategy for Achieving an energy ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effective and Resource efficient cleaning system for X-Ray Personal Protective Equipment (PPE)', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

RealStar S.r.l., the worldwide leader in the manufacture of innovative high quality dry-cleaning machinery, with 198 employees and a turnover of 46 MLN €, and SIMAD S.r.l., a consolidate player in the X-ray Medical Technology sector, with 13 employees and a turnover of 3 MLN €, have developed, together, CLEANI-Rad, an innovative system to completely disinfect, in an automatic way, lead aprons used in hospitals to protect surgeons and patients against radiation, avoiding damages in the lead film, what results in an increase of the security for users reducing X-Ray exposure and risks coming from infections thanks to the total cleaning. Moreover, it does not exist direct contact between users and contaminants. This also means economic savings due to the reduced infection costs, that nowadays suppose 65 billion € annually in Europe, and new personal protective equipment investments. CLEANI-Rad its effective and resource efficient, as it supposes water savings, compared to hand-washing method, thanks to its water filter’s system, and a reduced amount of lead discharged to the environment (about 21 Kg/year per each 150 lead aprons). In addition, CLEANI-Rad is equipped with an innovative software that register every washing operation optimizing the control and maintenance of the lead aprons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Preclinical evaluation of delivery systems for neuroprotective gene therapy in neurodegenerative diseases.' in the context of a Fifth Framework call.

assistant: **Objectives**

The long-term objective is to provide a comprehensive pre-clinical background for neuroprotective therapies, using gene therapy delivery systems developed by European biotechnology companies, in patients with neurodegenerative diseases. Experimental studies have pointed to the trophic factors CNTF and GDNF as potential neuroprotective agents for striatal and nigral neurons, respectively. In parallel, gene therapy systems to deliver these proteins directly to the brain are developed in Europe. A systematic analysis of the parameters that must be specified for clinical application will be performed, in order to determine the safety conditions, the quantify of proteins released for therapeutic effects, their spread away from the site of production and the time-course of release, the final goal being to provide clinicians with therapeutic tools to be applied in patients with Huntington's or Parkinson's diseases.Description of the workThe work will be assembled in seven workpackages ordered to take all preparatory steps to be taken before therapeutic protocols are experimented in non-human primates. Three gene therapy delivery systems for the ciliary neurotrophic factor (CNFTF) and the glial cell line-derived neurotrophic factor (GDNF), with neuroprotective capacity for striatal and nigral neurons respectively, will be experimented in parallel, based upon HSV-1, immortalized human cells or encapsulated genetically-modified cell lines.WP1 will define conditions for safe delivery to the brain. In parallel, WP2 will establish imaging protocols to assess neuroprotective effects by in vivo quantitation of neurons and evaluation of function. WP3 and 4 will examine temporal and spatial characteristics of the delivery of CNTF and GDNF.Experimental therapeutic procedures will then be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Enabling the continuous monitoring of drinking water with an all-in-one sensor'.

assistant: **Concept**

The CENSE Integral probe combines 5 water quality monitoring sensors in one: temperature, turbidity, pressure, conductivity and chlorine. The chlorine sensor developed by the CENSE team is a brand-new technology based on a microfluidic lab-on-chip. This new technology is far more affordable than the more standard colorimetric and amperometric methods; it is also much less hazardous to handle and can withstand high pressures and challenging conditions. Installation costs are low and the time taken to replace an amperometric sensor with the Integral probe is minimal. EFS listened to and answered the needs of its customers – there has been a lot of demand for a high-performance low-cost chlorine sensor within the drinking water sector. The feasibility studies have shown that uptake of the new probe will be large, and its release is much anticipated. EFS have already gained trust within the drinking water sector, thanks to the success of their previous water probes. Sales will be made via direct sales and indirect sales, through EFS’ extensive distributor network. The team working on CENSE are experienced and have brought multiple water probes and water sensing technologies from lab to market already. The new technology will be rolled out initially in France, Germany, Italy Spain and the UK. France was chosen to be the kick-off point for several reasons: first of all EFS is based in France and has a strong network there, and secondly France is home to several global market leaders in drinking water provision: VEOLIA, AQUALTER and SUEZ, to name a few. From year 3 the product will be launched in the rest of the EU with a global launch beginning year 5.


**Keywords:** water quality, chlorine, monitoring, sensor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Intergenerational transfer of ageing: effects of maternal age at breeding on offspring performance'.

assistant: **Innovation**

Ageing research has primarily focused on somatic deterioration of individuals during their lifetimes; intergenerational effects have been little studied. In this project I address this gap, in the process bringing together currently discrete lines of research from evolutionary ecology and reproductive biology:1) A large body of research in population biology shows that there can be a negative relationship between parental age at breeding and offspring lifespan. It has been postulated that the magnitude of the effect is exacerbated when offspring experience harsher conditions, particularly in early life. The causes and time-course of this so-called ‘Lansing effect’ are unclear - is it due to higher lifetime frailty of offspring, a faster ageing rate, or both, and how is it affected by the environmental conditions that they face? 2) Telomere loss and mitochondrial dysfunction in somatic cells are two recognised, interconnected, ‘Hallmarks of Ageing’ linked to individual performance and longevity. Experimental work, mostly in fertility research, has shown that the eggs of older mothers frequently have reduced mitochondrial function and shorter average telomere lengths. The life-course outcome of this gametic impairment for the offspring has not been studied.   Using the zebra finch, this challenging, high-gain, project tests for the first time the hypothesis that the negative effect of maternal age on offspring performance and ageing rate is due to lifelong, intertwined changes in offspring mitochondrial function and telomere length, and is exacerbated in offspring experiencing increased early life stress. Knowing why, when, and under what conditions maternal age has a negative effect on offspring health and longevity has important implications for our understanding of age
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of Stereoselective Olefin Functionalization Methods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The ability toThe ability to readily access small-molecule building blocks at will has important consequences for the discovery and development of novel medicines and materials.  It is particularly beneficial when the chemical methods are convenient while at the same time economically and environmentally tenable and sustainable. We are especially interested in catalytic processes that are easily executed and utilize readily available starting materials to produce optically active products with high regio, chemo, diastereo, and enantioselectivity.  The proposal aims to discover, develop, and study a collection of enantioselective olefin functionalization reactions that provide access to useful building blocks, such as amines, azides, hydrazines, nitriles, alcohols, involving acyclic, cyclic and bicyclic structures. The catalyst will be derived from earth abundant metals, such as Fe, Mn, and Co and incorporate novel chiral ligands. The study includes the design and preparation of two structural classes of novel, chiral boric acids that are expected to serve as catalyst for the enantioselective functionalization of unsaturated carboxylic acids and boronic acids. The methods are expected to substantially impact the development of novel strategies for complex molecule synthesis.  In this regard, we propose to use the catalysts form this study to convert dienes and trienes into polyols with characteristic stereochemical and oxidation patterns found in bioactive agents, including pharma- and nutraceuticals (carnitine). Such advances enable new approaches that go beyond the well-established methods such as aldol/allylation for the preparation of stereochemically complex fragments. Catalysts will also be developed that convert acyclic olefinic alcohols and amines into optically
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Using Kleptoplasty to illuminate the Evolution of Plastids and the Order of Steps during endosymbiosis' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Plastids, the photosynthetic organelles of eukaryotes, arose via endosymbiosis of cyanobacteria by a eukaryotic host and were subsequently spread across eukaryotic diversity by additional endosymbioses. These events greatly impacted the evolution of eukaryotes, introducing a novel lifestyle and shaping their diversity, yet we still know very little about the steps taking place during plastid endosymbiosis. The traditional view considers this a straightforward uptake and retention of the symbiont that later becomes the plastid, followed by genetic integration. Recently, profoundly different models proposing several, transient interactions with a variety of endosymbionts that transfer genes to the host before fixation of the final endosymbiont have gained traction. Kleptoplastidic species, lineages that transiently retain and use plastids from their prey, are at the centre of this paradigm shift, providing the first insights into the order of steps during plastid endosymbiosis. Kleptoplasty is rare, primarily found in a group of microbial eukaryotes, and the few kleptoplastidic taxa known have not been studied in the context of endosymbiosis. I propose here to resolve the process of plastid endosymbiosis using kleptoplasty as a unique model by addressing these questions: 1) What is the hidden diversity of kleptoplastidic taxa? 2) What is the level of genetic integration in these taxa? 3) What is the composition of the plastid proteome in a kleptoplastidic lineage? 4) How does the kleptoplast and control of the kleptoplast change during integration? To answer these questions, I will combine a novel imaging-based screen for kleptoplastidic lineages with high-throughput transcriptomics and phylogenetics and provide the first plastid proteome of a kleptoplastidic lineage. Thi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Smart Contract Analytics using Artificial Intelligence' (SCAI).

assistant: **Innovation**

The current global market for contract management is estimated in more than € 937 million. Still, the activities involved in contract managing are mostly carried out manually, which entails challenges such as the tracking of deadlines, keeping up with changes in regulations and enforcing company policies, resulting in average costs of 9% of the company’s annual revenues. The only help that professionals have are basic and inefficient tools that do not cover the whole contract lifecycle, forcing professionals to use more than 6 different software tools to carry out their job. Our new solution SCAI, provides a complete and reliable tool for all professionals managing legal documents by identifying provisions and comparing them against regulations and company policies, thus saving 90% of the time needed for document review. Based on Artificial Intelligence, SCAI combines an advanced Machine Learning engine with Natural Language Processing, achieving a recognition accuracy similar to humans. In addition, SCAI provides multilingual support that allows to compare laws and policies across different languages, which makes it a truly unique solution that outcompetes existing solutions and which specially addresses the needs of European companies. Thanks to this project, we expect to expand and internationalise our product from Switzerland, where our company is based, to Germany and Austria in a first commercialization phase, followed by France and Belgium, UK, Ireland and Spain. We plan to have a customer base of 60 large companies and 200 medium companies after 3 years of commercialization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Single-Molecule Resonant Tunnelling in Small Transition Metal Complexes - Towards Molecular Electronics' to be submitted under Sixth Framework.

assistant: **Abstract**

Molecular electronics is expected to become a key technology in the 21st century with extensive current research. Owing to its future importance, molecular electronics is included in one of the seven FP6 priority areas, viz Nanotechnologies and Nanoscience . Our project will contribute to both the theoretical understanding of functional molecular electronic devices, and to their development and application. Target systems are inorganic transition metal complexes attached to suitable conducting leads. These s ystems exhibit molecular conductivity features that mimick electronic components such as diodes or transistors. However, most work published so far has been at low temperatures in vacuum or air. We intend to expand the area to ambient temperatures using in situ STM and scanning tunnelling spectroscopy (STS) in electrochemical environments. The in situ STM electrode configuration consisting of a reference, a counter and a working electrode, resembles closely a molecular transistor with source, drain and gate contacts. Together with cooperation partners who will synthesize identified classes of inorganic complexes, we will develop molecular designs that are most suitable for our experimental requirements. Electrochemical experiments using ultrapure, atomically planar single-crystal metal electrodes will help to test the novel designs, e. g. concerning stability, prior to in situ STM experiments. In parallel, condensed matter charge transfer theory and detailed electronic structure calculations of the molecular tunneling junction will correlate molecular conductivity features to its properties. A profound understanding of this correlation is a pre-requisite to tailoring molecular tunneling properties, a key issue in present and forthcoming molecular electronics r esear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A Multisensory Environment Design for an Interface between Autistic and Typical Expressiveness'.

assistant: **Innovation**

MEDIATE addresses Key Action Line I.2.1 by R&D of an ambient intelligent authoring environment that supports progressive interaction with enacted nonverbal multisensory creations. To reach new levels of interactivity responding to the uniqueness of individuals, the environment will sense and feedback users' behaviour as integrated patterns of image, sound, and vibration. Recognition software will differentiate habitual from distinctive behaviours: stronger and more intense feedback follows distinctive behaviour, while the user maintains control. User creations can be stored and replayed. Developed with the aid of and for the use by autistic individuals, the resultant MEDIATE environment (which will be transportable) will allow such users previously unattained levels of sensory expression: for the benefit and enjoyment of the users and, for others, providing an insight into the sensory world of autism.DESCRIPTION OF WORKMEDIATE will be produced by the integration of technical skills, theoretical knowledge, and co-constructive design at a trans-European level. The project will proceed through a series of accumulative steps with the end users being integral participants at all times: high functioning autistic individuals from across Europe being co-authors as well as testers of the system. Sensory interfaces for the engagement, manipulation and creative feedback of touch, sound, and sight will be devised at independent locations in parallel during the first stage. The second stage will entail assembly of a full prototype ambient intelligent multisensory interface / environment, bringing representatives of all partners into the same physical location. During both stages an ongoing signature software development will functionalise each step of the evolving interface allowing