RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Modulation of complex lipids to promote healthy aging'.

assistant: **Concept**

Aging has long been considered a passive process that could not be reverted. Fortunately, it is now clear from genetic and pharmacological intervention studies that aging is actively regulated and can be influenced to reduce the burden of age-related diseases, such as neurodegenerative and metabolic diseases. Studies in various organisms established the importance of dysregulated lipids in the development of aging and age-related diseases. It remains unclear, however, how complex lipids and lipid metabolism causally affect aging, and the mechanisms are poorly understood. In my preliminary lipidomics analysis in ten different tissues of aged mice, I found a striking accumulation of bis(monoacylglycero)-phosphate (BMP) in all tissues. While little is known about BMPs, one lysosomal enzyme that has been described to contribute to its production is PLA2G15. Remarkably, knocking down Pla2g15 in worms leads to a significant lifespan extension. Together, these findings suggest a causal involvement of Pla2g15 in aging. I hypothesize that targeting complex lipid metabolism could promote healthy aging. Therefore, the main goal of LipidAge is to unravel the role of complex lipids, specifically BMPs in the development of aging, and how these pathways and their downstream effects impinge on lysosomal functions and healthy aging. I will use human and mouse lipid data profiles, worm C. elegans, and apply a combination of molecular, biochemical and phenotypic experiments with a focus on lipids and aging. These experiments will lead to a better understanding of conserved complex lipid changes, and the role of Pla2g15 in the BMP synthesis cascade relevant for health and disease during aging.


**Keywords:** Lipids, lysosomes, aging, phospholipids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Light weight airframe structures through combination with high performance materials' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A further step towards more light weight airframe parts is the combination of existing materials with new high performance materials. This project aims at qualifying new high performance materials for airframe structures following a bulding block approach. To do so, the three first levels of the building block approach will be covered, including coupons, elements and sub-structural details. State-of-the-art test will be introduced in the qualification test campaign that will provide useful material parameters for damage tolerance analysis.The consortium is formed by experienced partners in composite material testing and design. All the coupons and parts will be manufactured by an experienced manufacturer equipped with the latest manufacturing technologies, with the most demanding quality certifications and currently qualified by Airbus and Airbus Helicopters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Establishing Citizen Science Hubs in European Research Performing and Funding Organisations to drive institutional change and ground Responsible Research and Innovation in society'.

assistant: **Innovation**

Europe’s Research Performing and Funding Organisations (RPFOs) have a crucial role to play as agents of institutional change towards firmly grounding RRI in our society. The successful fulfilment of this challenging yet highly significant role calls for the values of RRI to be well-embedded into their governance as well as their operation with greater and more systematic participation of citizens and all R&I stakeholders. INCENTIVE is set on empowering European RPFOs to establish sustainable transdisciplinary hubs for stimulating and supporting excellent citizen science with engaged roles for all R&I stakeholders in line with RRI principles. To this end, we start by establishing and demonstrating the potential of such Citizen Science Hubs in 4 world class RPFOs covering all 4 MoRRI Country Clusters, including University of Twente (NL), Autonomous University of Barcelona (ES), Aristotle University of Thessaloniki (EL) and Vilnius Gediminas Technical University (LT). We tailor the governance and operating models of their hubs to their unique institutional specificities and regional ecosystems of R&I stakeholders, before putting them to the test to drive institutional change through a series of RRI-grounding actions conducted with and for society (citizen science, co-creation of public policies, R&I agenda setting, etc.). All in all, our Citizen Science Hubs, besides being a sustainable institutional change themselves, will serve as a vehicle for introducing substantial institutional changes in our RPFOs and their communities. We will closely monitor, evaluate and report the performance and outcomes of our Citizen Science Hubs and their actions, providing evidence of societal, democratic, economic and scientific impacts. Along the way, we will foster mutual learning and ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Theory of statistical topological insulators'.

assistant: **Innovation**

Topological insulators (TI) are a novel class of materials with insulating bulk and conducting surface. The conduction of the surface is protected by the topological properties of the bulk, as long as a fundamental symmetry is present (for instance time-reversal symmetry). My goal is to investigate to what limits does the protection hold in cases where the protecting symmetry is broken, and only present in statistical sense, after averaging over the disordered ensemble. In a pilot study I showed that materials that are protected by such average symmetry, which I have called “statistical topological insulators” (STI) significantly extend the classification of topological phases of matter and promise new methods to robustly control the conducting surface properties. I plan to develop a general theory of STI for physically relevant symmetries, describe the observable properties of their protected surface states, invent ways to predict whether materials are expected to be STI, and explore the generalization of STIs to strongly interacting topological phases of matter. I expect that the outcome of my research will significantly extend our understanding of topological phases of matter, and provide new ways to design materials with robust properties.


**Keywords:** Topological insulators and superconductors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'VALORISATION OF CO2 WASTE STREAMS INTO POLYESTER FOR A SUSTAINABLE CIRCULAR TEXTILE INDUSTRY' under Horizon Europe.

assistant: **Concept**

The textile industry is the fourth largest industry in the world with the global volume of fiber production for textile manufacturing reaching 110 million metric tons in 2020. At the same time, the textile industry is one of the most polluting industries worldwide with the highest greenhouse gas (GHG) emissions corresponding to 10% of the global emissions. Polyester (PET) is the most widely used fibre in the industry, making up 52% of the global market volume. No technology available today is capable of addressing the textile industry’s sustainability and virgin PET produced from primary petrochemical sources remains predominant with a fossil fuel consumption of 98 Mt annually which is expected to reach 300 Mt by 2050. Addressing the key challenges of carbon neutrality, circularity, cost, value chain adaption, and textile properties is the ambition of Threading-CO2, a disruptive project that will demonstrate on an industrial scale a first-of-its-kind technology that converts CO2 waste streams into sustainable PET textiles. Threading-CO2 aims to scale-up and demonstrate its first-of-its-kind technology producing high-quality commercially viable sustainable PET textile products from CO2 waste streams at industrial scale (TRL7) using a circular manufacturing approach and running on renewable energy sources. The overall outcome of the Threading-CO2 project is a 70% GHG emissions reduction compared to existing PET manufacturing processes. In addition, Threading-CO2 will enable the creation of a European value chain for sustainable PET textiles, from feedstock to final textile products in the clothing, automotive and sports/outdoor industries.


**Keywords:** Sustainable Textile, CO2 valorisation, recycled PET, Polyester, alternative feedstocks, first-of-its-kind technology,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated Refractory and Steel Recovery', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The steel industry is a strategic production sector, however it puts strong pressure on the environment because of the nature and quantity of material involved, gas emissions and waste. Of particular concern are 1) the huge volume of landfilled spent refractory, about 80-90% of total ladles and furnaces demolition material; and 2) the massive lime consumption, generating large amounts of CO2 emissions.To date no technology existed in the steel industry that achieved recycling rates higher than about 50%, can be performed in situ and permit the use of the vast majority of treated waste within the same production cycle. These assets would significantly reduce economic and environmental costs of steel production. Deref S.p.a. ( ‘DEmolizione REFrattari’) has a solid and long-lasting experience in the steel sector, and even more in steel refractory demolition, industrial waste management and metallurgical additives production. It developed a proper solution, tested it industrially at an Electric Arc Furnace plant for stainless steel production, and achieved a 95% recycling rate with 80% reuse in the same production plant and very high cost savings. It now sees a high potential to capitalise these huge achievements by focusing the entire steel production  market - consisting in more than 18 relevant sized steel plants in EU and much more in the rest of the world.Hereto, Deref will optimise and adapt its patented and proven technology to all types of steel production cycles and steel grades and validate results within large-scale trials and demonstrations, performed with at least 7 big steel producers, to obtain confirmation on the suitability of the treatment cycles in different use cases and to provide for evidence to the market.  It will also standardise protocols and desig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A disruptive smartphone application to measure three-dimensional spaces to digitally evaluate and   view associated surface data'.

assistant: **Objectives**

B&M THYSSEN GmbH is a German ICT-SME specialized in the development of onsite or room measurement software. Wehave developed and patented a disruptive and cost-effective method to measure rooms and spaces simply, accurately andquickly using a smartphone camera and internal sensors. With the project, we aim to further develop, test and commercialisethe roometric3D smartphone application.Traditional onsite or room measurement methods are complicated, time-consuming and error-prone. These methods aretaught in vocational training and are based on the use of tape measures, and square and triangulation formulas. However,these traditional methods are too slow and not commercially competitive in today’s business environment, and there is alsoshortage of workers with onsite or room measurement qualifications, partly due to the trade not being attractive to youngpeople.Even with availability of other onsite or room measurement solutions like 2D mobile apps, hybrid between mobile apps andlaser, apps with flow plans, tachymeter, laser with handsets or tachymeter (stand devices), the customer still faces a limitedchoice of:• Low-cost, fast, but low accuracy solutions (target group: consumers),• Mid-price, slow, cumbersome, mid-accuracy solutions (target group: tradespeople),• High-cost, high (millimetre) accuracy solutions (target group: surveyors).roometric3D will provide a highly competitive advantage in all three criteria: speed, cost and accuracy and will enable themeasurement of 3D spaces, which currently no competitive smartphone app can provide.We have a clear business opportunity to expand our sales and grow our company by commercializing our disruptiveroometric3D smartphone app. The app will allow fast and easy measurement of rooms and spaces in three dimensions forthe firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced heating system and control mode for homogeneous high temperature curing of large composite repairs' (ADVANCED) under Seventh Framework.

assistant: **Objectives**

The required elevation of temperature for curing of composite repairs is usually achieved by resistance heating blankets, controlled through spot temperature measurements. Although this method is simple and works adequately for small repairs, when larger areas are heated, cold or hot spots frequently occur, due to variable heat losses, caused by geometrical asymmetry etc. For this reason, autoclave curing of large repairs is currently used, as the most reliable curing methodology, which is however accompanied by high cost, wastes and energy consumption. The scope of this proposal is to enable the extension of heating blankets technology for the treatment of large repairs (e.g. reversers), currently requiring autoclave heating. A five step process is proposed:a)Thermal transfer simulation, to retrieve the “thermal signature” of the part and experimental validation using heat flux sensors,b)Manufacturing of thermal blankets, namely adapted Variable Heating Elements (VHE), with denser or coarser heating elements inside, and standard Compensation Heating Elements (CHE), in order to compensate for dissimilar heat losses,c)Development of universal Advanced Heating Control Unit (AHCU), with innovative programmable closed loop control,d)Development of a specialized High Power Supply Unit (HPSU,e)Process validation. It is expected that, this innovative methodology will allow the performance of structural repairs, either totally out-of-autoclave or in combination with autoclave treatment, as required, thus improving the overall heating process and achieving large scale economies compared to current autoclave solutions. Given that specified repairs are generally standardized, steps (a) and (b) will only need to be performed once per P/N to be repaired, while the developed equipmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid Retinal Prosthesis: High-Resolution Electrode Array Integrated with Neurons for Restoration of Sight' (HybridRetina).

assistant: **Innovation**

Vision restoration in patients with outer retinal degenerative diseases, such as Age-related Macular Degeneration and Retinitis Pigmentosa can be achieved by bypassing the degenerated photoreceptors and the electrical stimulation of the relatively well-preserved inner retina through electrode implants. Although current retinal prostheses have been shown to provide useful vision in blind patients, the obtained visual acuity and quality are still relatively low. Several challenges cannot be addressed with the current retinal prosthetic technologies. First, increasing the electrode density for achieving high visual acuity is limited by the distance between the electrodes and the target neurons. Second, electrical stimulation by the current technologies is not selective for specific retinal circuitry (e.g. ON and OFF pathways). Finally, retinal neurons are stimulated by pulsed rather than in a continuously graded potential fashion, which provides the photoreceptors with an unrivalled dynamic range and sensitivity in natural vision.Here we propose a paradigm shift toward sight restoration with a hybrid retinal prosthesis aimed at overcoming the aforementioned limitations. The hybrid implant is composed of a very high density electrode array (pixel distance of 15µm) coupled with neurons to create a tight neuron-electrode coupling. Following implantation of the hybrid prosthesis, the neurons integrate and synapse with the host retinal circuits. Upon patterned electrical stimulation of the neurons by the electrodes, the host bipolar cells are activated while preserving the natural vision circuits. The ultimate electrode-neurons proximity allows for the significant increase in pixel density, the low charge neural activation, and the continuous graded potential activation. This r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bioinformatics and Integrative Genomics for a Novel Personalized Cancer Therapy' (PERSMEDOMICS), addressing dissemination and exploitation.

assistant: **Impact**

The dawn of the age of personalized cancer treatment provides the promise to identify the right drug for the individual that will greatly improve the patient’s outcome.  It is well known that cancer drugs work only in small subset of patients.  For many of these agents, there are putative markers of response in the literature but very few are been used in clinical practice. More importantly, new anticancer agents are targeted to specific cancer genes and are expected to be effective only in tumors in which these genes are mutated or otherwise abnormal. Consequently, the success of personalized treatment of cancer patients depends on matching the most effective therapeutic regimen with the characteristics of the individual patient, balancing benefit against risk of adverse events. The primary challenge in achieving this goal is the heterogeneity of the disease, recognizing that breast, lung, colon and the majority of cancers are not single diseases but rather an array of disorders with distinct molecular mechanisms.High-throughput technologies such as next-generation sequencing, gene expression microarrays have the capacity to dissect this heterogeneity and now doing an unbiased interrogation of the human genome, which allows strategies to search for novel, previously unsuspected, biomarkers of drug response and afford opportunities to match therapies with the characteristics of the individual patient’s tumor.Here we propose to develop an integrative bioinformatics approach as part of CNIO’s personalized cancer treatment platform that will predict treatment response and select new biomarkers based on the integration of genomics data and drug response analyzed in patients with pancreatic cancer and personalized xenografted mice. A cross-disciplinary integrative effort tha