RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Defining and modulating the stress granule proteome as a therapeutic strategy in Amyotrophic Lateral Sclerosis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

How do you study a disease with no known cause? Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. Patients typically die 3-5 years after symptom onset. There is no cure. Finding a cure is hindered by the lack of obvious causes: although 10% of patients show familial inheritance (fALS), 90% of patients exhibit a sporadic form of ALS with no known cause (sporadic ALS, sALS). Almost all ALS patients demonstrate intracellular inclusions of the RNA binding protein TDP-43. However, it is not clear what process allows TDP-43 to aggregate, especially in sALS. This will be the focus of the proposed StressOME project. TDP-43, and other ALS-associated proteins are recruited into stress granules, transient structures that form in response to cellular stresses. Stress granules are thought to constitute a microenvironment with a high local concentration of TDP-43, sufficient to allow its aggregation; however this is prevented in healthy neurons. Therefore, the composition of stress granules may be crucial in the pathogenesis of ALS. To determine whether the dynamics of stress granule assembly and disassembly are different in patient cells, I will derive skin cells from fALS and sALS cases and compare them to age-matched controls. In parallel, I will use a new technique called ‘biotinylation by antibody recognition’ to define the stress granule proteome in sALS and fALS patient cells for the first time. This will allow me to identify candidate genes that modulate stress granule dynamics. I will generate stress granule reporter lines and misexpress candidate proteins, using live cell imaging to determine their effect on the dynamics of stress granules and the recruitment of TDP-43. Candidate genes will also be misexpressed in Drosophila models expressing T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety and Awareness For Everyone in Virtual Reality' (SAFE-VR) under Horizon Europe.

assistant: **Objectives**

Social virtual reality (VR) is rapidly transforming how people interact. It creates immersive virtual spaces for social engagement, such as leisure activities, remote work, training and other social events. However, the rise of these platforms has brought significant challenges to user safety. The SAFE-VR (Safety and Awareness For Everyone in Virtual Reality) project aims to develop a comprehensive system to mitigate harassment in social VR by automatically detecting it and providing immediate user support. The first objective will be achieved by analyzing group movement patterns with machine learning methods to detect harassment in social VR. The second objective consists of two parts: 1) dynamic, context-aware personal boundaries that adjust based on the nature of interactions and user preferences, and 2) an intuitive reporting system that automatically captures relevant data when harassment is detected or a report is initiated, easing the process for users. These solutions will be integrated and delivered through the open-source SAFE-VR platform. Perceptual studies will be conducted to evaluate the platform’s efficiency, effectiveness, and its impact on user behavior and sense of safety. An industrial secondment with Virtual Bodyworks, a company specializing in VR for behavioral change in corporate and rehabilitation settings, will provide opportunities to explore real customer needs and tailor the SAFE-VR platform for their commercial VR applications. By delivering adaptable safety mechanisms, this project has the potential to influence future social VR safety standards and benefit developers, users, and policymakers alike.


**Keywords:** Virtual humans, computer animation, perception
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Old English Identity and the Final Stages of the Tudor Conquest of Ireland, 1599-1603' (OEIFTCI) under Seventh Framework.

assistant: **Objectives**

Ireland’s Nine Years’ War (1594-1603) marks a crucial juncture in the development of three unique cultural identities: Gaelic Irish, Old English, and New English. But, while this war reinforced the socio-religious character of the Gaelic Irish and New English, it compelled the descendants of Ireland’s twelfth-century Anglo-Norman conquerors, known collectively as the Old English, to reappraise their status as Irish-born Catholics loyal to the English Protestant establishment. Building upon my doctorate, which examined aspects of Old English identity formation within the Pale – an area roughly comprising counties Dublin, Kildare, Meath, Westmeath, and Louth – during the first stage of the Nine Years’ War (1594-1599), this project will consider the same community during the second stage of this conflict (1599-1603). This war is best studied in two phases because the April 1599 arrival of the Earl of Essex as Lord Lieutenant of Ireland coincided with a marked escalation in hostilities, an increased commitment of money and manpower from England, the resurrection of a militant Jesuit mission, and the deployment of an aggressive patriotic propaganda campaign by the Irish Catholic Confederacy. The impact of this intensification on the Old English Pale community would have been noticeable and this project will explore how escalating hostilities, clerical involvement, and the production of patriotic propaganda during the second phase of Ireland's Nine Years’ War contributed to the emergence of a distinct Old English identity by the early 1600s.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SECURE-JUSTICE: secure communication and collaboration framework for the judicial co-operation environment' (SECURE-JUSTICE).

assistant: **Innovation**

The SecurE-Justice project concerns the design and development of innovative secure technologies to be embedded in a distributed communication and collaboration framework to be implemented in multiple judicial sites. The SecurE-Justice system will therefore enable the judicial co-operation process management in compliance with security requirements and trust and confidence needs. The project idea originates from a fact: public administrations being multi-site and having to deal with distributed process management, have expressed their needs in terms of security compliant systems and ask for a global security management framework, enabling a secure collaboration and co-operation environment.The overall platform of SecurE-Justice will consist in a technological product:- based on the embedding of the most innovative security technologies into a unique technological solution enabling secure communication and knowledge sharing in a large multi-site organisation context;- oriented to the security market in general and particularly devoted to the market of security management in a distributed environment and judicial co-operation.The two fundamental research action lines addressed by the project are:- secure user management: identification, authentication and authorisation of users; PKI, digital certificates and biometrics identification technologies;- secure communication management: confidentiality, integrity and non repudiation; SIP message encryption, SecureRTP and digital watermarking technologies.SecurE-Justice lasts 36 months, gathers a wide and qualified consortium that brings to the project a unique mix of complementary skills and expertise. It is a technology oriented and user driven project: four multi-site judicial public administrations involved will test and val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'My dear little friend: letters to the ruler. Childhood and Political Culture, a Transnational Approach to the Iberian Dictatorships and the Brazilian New State (1930-75)' under Horizon Europe.

assistant: **Concept**

In December 1953, an 11-year-old Portuguese girl wrote a letter to Salazar. Maria asked him to use bombs to defeat Russia and communism. The letter said: “You, Doctor Oliveira, who rules this country so well and loves peace, should put an end to these bad people who are hurting everybody.” Hundreds of letters like Maria’s are at the National Archive of Torre do Tombo. This research proposal follows an inventory of these documents, including two other sets of letters addressed to Spanish and Brazilian dictators Franco and Vargas - archived in their respective countries - whose analysis can be found at the intersection of political and childhood histories. In Europe and America, the first decades of the 20th century were marked by the rise of political regimes which, to spread their ideological values and shape the character of the nation, deployed mass media as political propaganda tools. These regimes collaborated in the construction and consolidation of political cultures in which their rulers seemed to merge with the State. This research will focus on Salazarism, Francoism, and Varguism, from the perspective of Transnational History, and it is based on the articulation between a set of state initiatives, centred on a nationalist ideology, and children’s overlooked participation in this state-building process. In Spain, Portugal, and Brazil, there are several works dedicated to the analysis of epistolary writing in the context of authoritarianism. However, little has been devoted to letters written by children, and none about children's letters to government officials. The originality of these sources thus represents an important innovation in the studies of the authoritarian pasts of those countries through the perspective of children, a marginalised subject in histor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ANISOPTER: The Affordable Optimization Solution for Anisogrid Structures' to be submitted under Horizon 2020.

assistant: **Abstract**

An affordable access to Space is crucial for the sustainable development of European industry. However, the 14 k€ required to send each of the 200,000 kilograms yearly sent to Space slows down, and even prevents, the development of new business models. Thus, there is a huge necessity to reduce spacecrafts and launchers weight. Industry and academia agree in that new anisogrid structures are one of the best ways to accomplish this challenge, but these complex structures must be optimized for each application to obtain the best performance.   It does not exist yet a fully automated commercial solution to optimize anisogrid structures. Space companies are forced to spend thousands of euros in the optimization and accuracy assessment of the designed models. All commercial software available is very expensive and relies on the computationally demanding Finite Element Analysis and manual or semi-automated optimization protocols. In contrast, ANISOPTER uses analytic equations to predict the behaviour of anisogrid structures, explore millions of configurations, and obtains in minutes 10-40% lighter structures than the competence. Our Software-as-a-Service solution will provide the optimal solution through a simple web interface at http://anisopter.com    Despite ANISOPTER´s main users are manufacturers of satellites and space launch systems, there exist a huge business opportunity on Earth for anisogrid technology. The entry of this game-changing technology on Earth markets is prevented by modelling difficulties and cost. Thus, the ease of use and speed of ANISOPTER will clear the way for the application of anisogrid concept in load-bearing components, like towers for electricity transport or wind power generation, and offshore jackets or oil platforms.   Our main objectives ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trustworthy AI Tools for the Prediction of Obesity Related Vascular Diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Weight problems and obesity are increasing at a rapid rate already concerning more than 436mio people in European countries. Obese persons have a 50% higher risk of cardio-vascular disease (CVD) mortality and treatment costs result in a  total economic burden of over 210 billion Euro per year. To date the prediction of the individual risk  for major adverse CVD events in the obese patient population is a challenge. Current risk scores are not sufficiently accurate and there is no implementation of scores into user friendly solutions. The AI-POD project aims to reduce the number of CVD related deaths in Europe by developing an AI-based risk prediction score to support clinical decision making and by equipping obese persons with trustworthy AI tools. AI tools will integrate clinical, laboratory and imaging data to translate disease risk into actionable health information to guide diagnostic steps and treatment recommendations. The tools will be validated in six clinical sites on CVD and serve as the basis for a lasting interdisciplinary platform for distributed learning in other vascular territories. AI-POD will push the boundaries of clinical insight in CVD in obese persons, including its treatment and risk management. AI-POD main outcomes are (1) a novel imaging-based AI-based risk score and Clinical Decision Support System (CDSS) for the risk assessment and prediction of obesity-related CVD and associated complications as a pre-requiste for further AI-based prevention and treatment management; (2) an innovative, easy-to-use mobile app for citizens (Citizen App) that interacts with the CDSS empowering obese people to better monitor and manage their own health. Physicians will benefit from more efficient workflows and in consequence, public health budgets will be unburde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Accelerating the sustainable production of advanced biofuels and RFNBOs - from feedstock to end-use'.

assistant: **Innovation**

FUELPHORIA will demonstrate the establishment of sustainable complete value chains for advanced biofuels and RFNBOs for providing Europe with sustainable, secure and competitive energy supply schemes. The project will practically showcase a portfolio of nine complete Value Chains which will be set up and tested in real environment contexts with the active participation of all key players including: the feedstock suppliers (two biogas plants, a winery plant, an urban waste treatment plant); the technology providers who will convert through chemical, electrochemical, biological, thermochemical, and photobiological processes the feedstock (CO2, digestate, urban/ municipal biowaste) into an array of advanced biofuels and RFNBOs (light to long parafins i.e. CH4, medium/long chain hydrocarbons, esters i.e. biodiesel, and light alcohols i.e. ethanol, methanol) that meet quality specifications as defined by the end-users in the transport sector (aviation/maritime, road transport) and in the power production sector (gas or oil fired thermal plants), through four DEMOs in Europe (Belgium, Spain, Greece) while European export potential through international collaboration with Africa is also envisaged. Special emphasis will be also given to the logistics around the fuel production systems, i.e., for the sustainable supply of feedstock and the efficient transport of the final products to their end application. To do this, across the FUELPHORIA project the value chain approach is combined with the Life Cycle Assessment approach in order to not only consider all the different stages of the value chain from feedstock to end use but also to explore how the value chain operates as part of a larger system. FUELPHORIA will define and setup business models and marketing concepts and prepare
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Relative importance of founder effects, local adaptation and ecological thresholds on the distribution of alpine lake crustacean zooplankton' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

General Circulation Models predict that the temperature changes in remote areas such as the arctic and high altitude sites will proceed at a faster rate than the global temperature change, indicating that these areas might be at higher risk. Within alpine lakes, factors related with climate and lake size have been found to be significant for predicting the distribution of species of different taxonomic groups on a European scale (Catalan et al. 2006). Amongst them, the distribution of crustacean and rotifer zooplankton was found to be potentially affected by stochastic events such as founder effects either at regional or at local scale. Understanding species distributions and the relevance of environmental factors upon them, require an understanding of how local factors affect the dynamics of local populations and structure of metapopulations.In this sense, the study of local adaptation offers the more feasible alternative of comparison between local populations, which have evolved under different conditions. The main objective of the project will be to study the relative importance of founder effects, local adaptation and ecological thresholds for the distribution of crustacean zooplankton species in the Pyrenees. The project has been structured in three stages: first it will focus on detecting potential ecological thresholds of species distribution of crustacean zooplankton in the Pyrenean lakes using existing and newly collected data; second, it will describe the main traits distinguishing the different species and their trophic relationships focusing on a representative subset of lakes covering most of the species, which will be sampled on different occasions during a seasonal cycle.The final stage will be to investigate which of these factors are drivers and which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A multilevel integrative approach to microbial ecology: from molecular networks to cellular interactions in a spatially structured community' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Microbial communities profoundly influence global biogeochemical cycles and human life. Understanding their wiring is crucial to manage, rationally manipulate, or de novo assemble communities for environmental, industrial or medical applications. However, studying the complex web of microbial interactions and how they are affected by the spatial structure of the community is experimentally challenging. Here, I propose an integrative approach to dissect microbial interactions in a synthetic community consisting of two bacterial species of the human gut microbiota, the commensal Escherichia coli and the probiotic lactic acid bacterium Lactobacillus plantarum. These two species were predicted to engage in exploitative and mutualistic metabolic interactions depending on oxygen availability and provide an experimentally tractable and possibly health-relevant model community. I will employ a combination of highly sensitive quantitative analyses on the molecular level (proteomics, metabolomics, CRISPR/Cas9 genetic perturbations) with quantitative analyses on the individual cell and community level (cellular growth rates and spatial organization) to obtain a comprehensive mechanistic understanding of the interactions between the two species. The multilayered nature of the approach, including the conceptualization of the interactions with a mathematical model, is expected to provide novel insights into the fundamental principles underlying microbial interactions and how they are affected by the environment. Furthermore, a detailed understanding of the molecular interactions of L. plantarum with other gut residents could inform the rational modulation of the gut microbiome to treat diseases associated with dysbiosis. This fellowship would have a major impact on my career by facil