RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Network models for the computational design of proficient enzymes' to be submitted under Horizon 2020.

assistant: **Abstract**

Billions of years of evolution have made enzymes superb catalysts capable of accelerating reactions by several orders of magnitude. The underlying physical principles of their extraordinary catalytic power still remains highly debated, which makes the alteration of natural enzyme activities towards synthetically useful targets a tremendous challenge for modern chemical biology. The routine design of enzymes will, however, have large socio-economic benefits, as because of the enzymatic advantages the production costs of many drugs will be reduced and will allow industries to use environmentally friendly alternatives. The goal of this project is to make the routine design of proficient enzymes possible. Current computational and experimental approaches are able to confer natural enzymes new functionalities but are economically unviable and the catalytic efficiencies lag far behind their natural counterparts. The groundbreaking nature of NetMoDEzyme relies on the application of network models to reduce the complexity of the enzyme design paradigm and completely reformulate previous computational design approaches. The new protocol proposed accurately characterizes the enzyme conformational dynamics and customizes the included mutations by exploiting the correlated movement of the enzyme active site residues with distal regions. The guidelines for mutation are withdrawn from the costly directed evolution experimental technique, and the most proficient enzymes are easily identified via chemoinformatic models. The new strategy will be applied to develop proficient enzymes for the synthesis of enantiomerically pure β-blocker drugs for treating cardiovascular problems at a reduced cost. The experimental assays of our computational predictions will finally elucidate the potentia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Frequency Comb-Injection Locked Coherent Optically-Switched Transceivers for Intra-Data Centre Networks', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Data centres, comprising tens of thousands connected servers, are the underlying technology empowering everything we do online. Driven by cloud computing and big data services, server-to-server traffic in data centres is increasing at an annual rate of 70%. This has motivated the development of 400G Ethernet, which is expected to scale to ≥1.6Tb/s in the future. This increase has resulted in both architectural and interconnection challenges.The first challenge is the scaling of the data centre network, which is expected to reach hundreds of thousands of servers. This trend has driven research in optical switching as an alternative to electronic switching for its fast switching in nanoseconds. The second challenge is the scaling of the data rate of the server-to-server interconnects. This makes coherent transceivers attractive as they offer higher spectral efficiency than current intensity-modulation direct-detection schemes.Future intra-data centre interconnects therefore require revolutionary technologies to address both challenges. But commercially available coherent transceivers, which are designed for long-haul, continuous data transmission, cannot meet the requirements for optically-switched data centre interconnects. Technical challenges include fast wavelength tuning, low-latency optical carrier recovery and equalisation.In COINCOST, I propose to develop coherent optically switched transceivers by designing and optimising frequency comb and injection locking techniques that address these technical challenges. These will be realised in photonic integrated circuits (PIC) in a cost- and power-efficient fashion and demonstrated in systems on the host’s unique platforms.COINCOST draws on interdisciplinary but complementary expertise from the host, industrial partners,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart maintenance of Aviation Hydraulic Fluid using an onboard monitoring and reconditioning System' (SUPERSKYSENSE), addressing dissemination and exploitation.

assistant: **Impact**

Aviation hydraulic fluids are hygroscopic and, as a result, their lifetime is highly unpredictable. The performance of the entire aircraft hydraulic system is affected by the condition of the hydraulic fluid and if degradation goes undetected, it may cause damages with serious consequences. These may be economic at best or catastrophic at worst. At present, assessing the condition of the hydraulic fluid in an aircraft is laborious, time-consuming and expensive. Therefore the fluid is typically tested less than once a year, with the risk of unscheduled maintenance if the fluid has exceeded its limits of usage. Consequential interruption of the airline service bears a huge economic cost.This project proposes the development of an optimised maintenance concept based on an autonomous onboard system capable of monitoring the fluid condition and restoring it when required. This will increase the lifetime of the fluid yet prevent damage caused by degraded fluid. If external reconditioning or change of the fluid should prove to be unavoidable, this could be scheduled to coincide with regular service and maintenance operations, thanks to the predictive capability of the monitoring system. Fibre-optic sensors using luminescent indicators as well as alternative optical and electrochemical sensors will be developed for fluid monitoring. Similarly, different water separation and elimination techniques will be investigated and selected.The chosen approach yields a balanced-risk strategy in which established techniques are combined with cutting-edge research, the outcome of which results in concurrent individual deliverables of high intrinsic value, thereby enhancing the combined benefits expected from the project. The impact of this system would extend far beyond the consortium partn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'An expert chemical model for determining the environmental conditions needed to prevent salt damage in porous materials' (1994-1998) under Fourth Framework.

assistant: **Objectives**

To predict the behaviour of contaminating salts in stonework. This project will create a significant advance in the prevention of salt damage in stone, ceramics, wall paintings and other porous materials. It will provide a vital tool for all those who are charged with the conservation of European cultural heritage, informing them fully about the environmental and climatic conditions required to mitigate or prevent salt damage.Until now, prevention of salt damage has been attempted simply by keeping the ambient relative humidity (RH) as steady as possible. This approach can prove harmful, however, if the wrong RH is chosen. Selection of the appropriate RH is straightforward if the stone is contaminated with just one salt: one chooses an ambient RH well away from (and preferably below) the 'saturation RH' of that salt. However, this simple case is rarely encountered, and a large number of salts are usually present. These are derived, for example, from air pollution, sea-salt deposition or from the soil. The situation is then very much more complex. Salt damage occurs across a range of relative humidities, as crystallisation and phase transformations take place among the many combinations of ions that are possible. This entails the novel application of geochemical (thermodynamic) modelling techniques to predicting the behaviour of the aqueous solutions of mixed salts, and associated crystalline phases, that are encountered in stone. The thermodynamic model is linked to an expert system, which will provide the user with all the benefits of the complex science in a form which is simple and informative. It will be possible, for example, to enter the ionic analysis derived from a particular object or monument, and to receive back a statement of the environmental conditions tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Proportional Algorithms for Democratic Decisions' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The project is set in the field of computational social choice. We will focus on formal models describing scenarios, where a group of individuals, called voters, disagrees on certain matters, yet needs to make a collective decision. The decision must truly represents a compromise. We focus on group fairness understood as proportionality.  There are numerous real-life scenarios that involve collective (public) decisions, and where our solutions could be applied. Examples include: elections of representative bodies (such as parliaments, faculty boards, etc.), participatory budgeting elections (where citizens decide how to allocate a part of a municipal budget), or scenarios where certain local communities (say, housing cooperatives) make series of decisions. In addition, proportional algorithms for making collective decisions can be used for selecting nominees for an award, for constructing rankings of movies or books, for selecting validators in consensus protocols, such as the blockchain, for constructing rankings of web-pages in response to user queries, for locating public facilities, or for improving genetic algorithms.The goal of this project is to develop generic methods of reasoning about equity of treatment of voters, and to design new algorithms that satisfy the most demanding criteria of proportionality. The new methods should be applicable to a number of specific models that concern public decisions. We will (1) prove theorems specifying whether and under which conditions our notions of proportionality are satisfiable, and (2) we will analyse various rules and algorithms with respect to our criteria of proportionality and other important desiderata that are commonly considered in social choice theory. We plan to (3) determine the computational complexity of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DevelOpment of GRID Environment for InteRaCtive ApplicationS' to be submitted under Fifth Framework.

assistant: **Abstract**

The Cross Grid project will develop, implement and exploit new Grid components for interactive compute and data intensive applications like simulation and visualisation for surgical procedures, flooding crisis team decision support systems, distributed data analysis in high-energy physics, air pollution combined with weather forecasting. The elaborated methodology, generic application architecture, programming environment, and new Grid services will be validated and tested thoroughly on the Cross Grid test bed, with an emphasis on a user-friendly environment. The work will be done in close collaboration with the Grid Forum and the Data Grid project to profit from their results and experience, and to obtain full interoperability. This will result in the further extension of the Grid across eleven European countries.Objectives:The project objectives are: expanding the Grid for a new category of applications in medicine, environmental control, and physics, running interactively, and extending the Grid infrastructure across eleven European countries. Efficient development of these kinds of applications on the Grid requires new tools for verification of source code, performance prediction, evaluation and on-line analysis. The Grid will be equipped with new components for monitoring of application performance, efficient distributed data access, specific resource management, as well as portals and mobile personalised user interfaces. The new software will be validated and tested on the Cross Grid test bed. Cross Grid will collaborate closely with Data Grid - a common cluster project is planned to obtain full interability.Work description:The work of this project will research, design, develop, implement and test the technology and components essential for the implementation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Processes of family building and the professional integration of women - a study of institutions and behaviours'.

assistant: **Concept**

This project aims at studying the relationships between the process of family formation and the determinants of female work supply, through a comparative study within the countries of the European Union (and more particularly between the United Kingdom and France). On the one hand, this study will be based on a longitudinal analysis of Eurostat Labour Force Survey data, in order to put into light a variety of stylised facts relating to the changes in the demographic situation and the female situation with regard to the labour market. On the another hand, we will focus on the integration of socio-institutional aspects in the analysis of the female behaviours relating to the labour market. This will lead us to set the issue of the level of decision relating to female work within the household, and to consider the place of rationality as the main determinant of this decision.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanomechanics of defects in solids: applications to nanolayers, nanoparticles, nanocrystals and biomaterials' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of the proposed project is to continue the research on a general nanomechanics of defects framework for the understanding and prediction of structure-properties relationships of nanoscale materials. This framework has to be suitable for metal nanoparticles and nanorods, nanolayered films and core/shell nanowires, ultrafine grained bulk nanostructures, as well as carbon nanotubes and protein membrane nanotubes. While standard continuum mechanics and dislocation theory have been useful tools for addressing scientific and technological problems at macro and meso scales, their direct use is not suitable for nanoscale problems. Molecular dynamics simulations and their variants is a commonly used approach but also prohibitively expensive for realistic applications due to current computational limitations. The proposed project serves as a compromising alternative by developing a new methodology for understanding the evolution and stability of structural defects at nanosized volumes and advancing new continuum nanoelasticity and nanoplasticity models for capturing the deformation and fracture behavior of nanosized objects, devices and components. The results will be applicable to a variety of nanoscience and nanotechnology areas, including micro/nano opto-electronics, micro/nano electromechanical systems, bulk nanostructured metal processing and forming. For the last objects, i.e. bulk nanostructured materials, experimental studies of their fracture and plastic behavior will be conducted to support the developed theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Synaptic Tagging and Capture: From Synapses to Behavior'.

assistant: **Concept**

It is shown that long-term potentiation (LTP) is the cellular basis of memory formation. However, since all but small fraction of memories are forgotten, LTP has been further divided into early LTP (e-LTP), the mechanism by which short-term memories are formed, and a more stable late LTP (L-LTP), by which long-term memories are formed. Remarkably, it has been shown that an e-LTP can be stabilized if it is preceded or followed by heterosynaptic L-LTP.According to Synaptic Tagging and Capture (STC) hypothesis, e-LTP is stabilized by capturing proteins that are made by L-LTP induction. The model proposes that this mechanism underlies the formation of late associative memory, where the stability of a memory is not only defined by the stimuli that induce the change but also by events happening before and after these stimuli. As such, the model explicitly predicts that a short-term memory can be stabilized by inducing heterosynaptic L-LTP. In this grant, I will put this hypothesis into test. Specifically, I will test two explicit predictions of STC model: 1) A naturally formed short-term memory can be stabilized by induction of heterosynaptic L-LTP. 2) This stabilization is caused by the protein synthesis feature of L-LTP. To do this, using optogenetics, I will engineer a short-term memory in auditory fear circuit, in which an animal transiently associates a foot shock to a tone. Subsequently, I will examine if optogenetic delivery of L-LTP to the visual inputs converging on the same population of neurons in the amygdala will stabilize the short-term tone fear memory. To be able to engineer natural memory by manipulating synaptic plasticity I will develop two systems: 1) A two-color optical activation system which permits selective manipulation of distinct neuronal population
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Robust light manipulation in plasmonic nanostructures assisted by topological protection' to be submitted under Horizon 2020.

assistant: **Abstract**

Materials that present plasmonic resonances feature the unique capability of confining light in nanometer-scale volumes. Resonant metal nanostructures, such as gold or silver nanoparticles, support localized surface plasmon resonances upon light illumination. These are free electron oscillations coupled to the electromagnetic field that enable light concentration even beyond the diffraction limit. For this reason plasmonics is a key tool for guiding and focusing light in order to extend the use of optical techniques into the nanoscale, with current and potential applications ranging from ultrasensitive chemical and biological sensor devices to imaging, non-linear optics or enhanced light absorption in photovoltaic cells.On the other hand, the study of topological phases and protected states in solid state systems as well as in photonic crystals has been very successful in recent years, since electronic or photonic states protected by the global symmetries of the system can propagate without suffering from scattering at defects or disorder. This has raised interest both from a fundamental point of view, with new physics being developed and understood –such as topological insulators–, as well as with views to applied technologies, which would greatly benefit from dissipation-free transport of electrons or photons. While the field of plasmonics has reached a mature state, the performance of some plasmonic devices is affected by ohmic losses in the metal and fabrication defects. Novel and improved functionalities are needed in order to design efficient plasmonic devices. This research aims at adding novel capabilities to the field of plasmonics by designing topologically protected light modes sustained by plasmonic nanostructures. I will study periodic two-dimensional arran