RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'eXtreme ultraviolet to soft-X-ray Photonic Integrated Circuits'.

assistant: **Objectives**

This project aims at the realization of a new technological platform for the development of a EUV - soft X-ray integrated photonics. Integrated photonics is a growing sector of photonics devoted to the realization of optoelectronic devices integrated in a single unit able of complex functionalities, with numerous and increasing applications. Current technology shares several aspects with semiconductor electronics; for this reason, the electromagnetic spectrum involved in integrated photonics is essentially limited to the infrared-to-visible range by the semiconductor band gap.The development of a novel technology able to manipulate high-energy photons in integrated devices may open integrated photonics to novel frontiers; in particular, the spectral range going form the extreme ultraviolet to the soft X-rays is very attractive for applications in Micro- and Nanoelectronics, Biology, Pharmacology, Material and Surface Sciences, Chemistry, Physics, Metrology and in many other fields.The ambitious goals of the project will be reached through the synergetic interaction among different disciplines as Ultrafast Laser Technology, Extreme Nonlinear Optics, Femtosecond Laser Micromachining, Fluid Dynamics, Nanotechnology, EUV to soft X-rays technology. The partners involved in this proposal are leaders in those research fields, thus making the ambitious project goals feasible. The innovative technology demonstrated in this project will be the base for a large variety of future devices offered to industrial and scientific customers, with functionalities tailored to specific applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Design and synthesis of selective inhibitors of human lactate dehydrogenase 5 targeting the peculiar metabolism of glucose in tumours' (LACTABLOCK).

assistant: **Innovation**

Highly invasive tumour phenotypes show a metabolic switch (“Warburg effect”) from oxidative phosphorylation to an increased glycolysis. This change in glucose metabolism, in favour of a less efficient process for production of energy and anabolites, confers several advantages on the tumour cells, such as the ability to grow in poorly oxygenated conditions, which are typical of invasive hypoxic tumours. One of the key enzymes actively involved in anaerobic glycolysis, the muscle isoform of human lactate dehydrogenase (hLDH5), was shown to be overexpressed by metastatic cancer cells, and has been linked to the vitality of tumours in hypoxia. This enzyme is currently being considered as a valid target for new anticancer agents, since its inhibition leads to a cut in cancer energy supply, thus reducing its metastatic and invasive potential. A validation of hLDH5 as a safe target derives from the observation that in humans, hereditary hLDH5 deficiency causes a certain level of myopathy only after intense anaerobic exercise, whereas it does not provoke any symptoms under ordinary circumstances. This project will support a qualified international researcher in the management of a research line including molecular design and synthesis of a series of new compounds, as well as in the participation in the biological evaluation of their properties. The host institution has already discovered a suitable structural scaffold, based on N-hydroxyheterocycles (NHIs), which has furnished some efficient hLDH5-inhibitors, possessing “first-in-class” potency and isoform selectivity. This scaffold will constitute the basis for the development of larger series of optimized NHI-analogues, as well as for appropriate variations of the central NHI-scaffold, leading to completely new classes of hLD
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'V2X Cell Free massive MIMO Networks with Active RIS: From Analytical Optimization to Federated Machine Learning' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The reconfigurable intelligent surfaces (RIS), cell-free (CF) massive multiple-input multiple-output (mMIMO), and vehicle-to-everything (V2X) are key technologies for next-generation wireless communication, i.e., beyond 5G and 6G. The CF mMIMO involves deploying many APs in a large geographical area to jointly serve all users. V2X allows vehicle user equipment (VUEs) to communicate with base stations, pedestrians, and other vehicles. The high mobility of VUEs leads to frequent handovers and channel ageing. This makes the CF mMIMO ideal for V2X since handovers are eliminated. To reduce the impact of channel ageing, more APs must be deployed which increases the power consumption. The RIS comprises many passive reflecting elements (REs), which can independently induce phase and amplitude change, with marginal power needs. Thus, the RIS can improve the spectral/energy efficiency (SE/EE). However, the passive RIS suffers from double-fading attenuation which may be detrimental for VUEs. This proposal seeks to analyze the SE/EE of the active RIS (aRIS)-aided CF mMIMO enabled for V2X. Each AP serves VUEs with the aid of multiple aRISs. We will derive closed-form solutions for the uplink/downlink SE by assuming imperfect channel state information, spatially correlated Rician channels, and channel ageing. For the aRIS, while increasing the reflected signal amplitude improves the desired signal, it also enhances the noise. Also, the aRIS requires extra power to amplify the signal which grows the network power consumption. The tradeoff between the SE and EE will be analyzed to identify the best operating regions.  Increasing the APs (or VUEs) transmit power may increase the SE but saturates at a point due to interference. Therefore, we seek to jointly optimize the power, aRIS ampli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PARticle IMAge VElocimetry and associated techniques' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Particle Image Velocimetry (PIV) appeared in the world of experimental Fluid Dynamics about 15 years ago. For these last 15 years, the VKI has been active in the development and promotion of this new Whole Field Velocity measurement technique. Apart from some colloquia, it has been necessary to organise practical training sessions in order to foster the penetration of these new techniques: two successive sessions devoted to this topic have been organised by the VKI on own funds in 88 and 96, which proved successful, but induced a significant deficit. Recent advances and improved knowledge in this field ask the need of a new course on PIV.This session will cover most of the aspects of the technique, from basic principles to practical applications including image acquisition, processing and 3D methods. Associated techniques such as LIF (Laser Induced Fluorescence) and PTV (Particle Tracking Velocimetry) will also be presented. Practical demonstrations will be organised. They are necessary for a better understanding, but both administrative problems and technical staff required will be increased for such a session. At the end of this event, each participant should be able to carry out this method and to optimise its use for his own research.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00070-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Bioanalytical Microsystem Based On An Optical Microchip' (BIOMIC) targeting Fifth Framework.

assistant: **Abstract**

The objective of the proposal is to develop a working prototype of a portable bioanalytical microsystem for clinical and biological applications. The microsystem is based on a monolithically integrated miniaturized silicon optical biosensor equipped with immunoaffinity and DNA recognition layers. The optical transducer consists of light sources, optical fibres and detectors monolithically integrated on a silicon chip through integrated circuit technology and is capable of performing fast assays without the need of external optical components. The system will also consist of the control and signal processing electronics, the appropriate packaging of the sensor die, the microfluidic module and the basic analysis software. Due to the miniaturized optical transducer die it will be suitable for point of use biomedical, industrial and environmental testing.Work description:The micro-optical chip, which is the heart of the proposed system, uses as light emitting devices silicon avalanche diodes while the detectors are standard p/n junctions optically coupled to the light emitters by Si3N4 waveguides. Here, the new element is the self-alignment of the Si3N4 fibre to the emitter and the detector and the way the fibre bends from the field oxide to the end points of the optical link for efficient coupling. Such a device will be fabricated through standard Silicon processing steps including oxidation, (wet and dry) implantation, annealing, film deposition by LPCVD and 5 lithographic steps. After silicon processing is completed, the fibres are properly and selectively derivatised by a number of recognition biomolecules and the chip is packaged along with the microfluidics module and the control and the processing electronics. The sensor performance will be tested against specific an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'COgnitive radio systems for efficient sharing of TV white spaces in EUropean context' (COGEU) targeting Seventh Framework.

assistant: **Abstract**

The complete transition from analogue to the digital TV is planned in Europe for 2012. This will release significant amount of valuable spectrum in VHF/UHF bands. In fact, the Digital TV Switchover provides a once in a lifetime" opportunity for the development of innovative services and the introduction sophisticated new technologies into the VHF/UHF bands.<br/>However, despite the grand words about opening up a new band to support low cost, low power, ubiquitous access and innovative new providers, there are many obstacles to TV white spaces systems. The creation of workable devices that clearly demonstrate and prove that no harmful interference is caused to broadcasters or other licensed systems is one of those challenges as is the completion of standards.<br/>The CogEU proposal aims to take advantage of the transition to digital TV by developing cognitive radio systems that leverage the favourable propagation characteristics of the TVWS through the introduction and promotion of real-time secondary spectrum trading and the creation of new spectrum commons in the upper band of the cleared spectrum. CogEU will also define new methodologies for TVWS equipment certification and compliance addressing coexistence with the DVB-T/H European standard.<br/>Three main application scenarios with good market potential will be investigated:\tCellular, WiFi and WiMax network extension over TV white spaces\tMobile TV over TV white spaces\tPublic safety applications over TVWS<br/>As a consequence the project should help the European decision makers and standards to move the TV spectrum management paradigm towards a more liberal and efficient method, by providing sufficient evidence on the technology and economic viability of its deployment. In fact the project timeframe perfectly m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Generalisation into sentence and predicate positions'.

assistant: **Innovation**

Generalisations are fundamental to every scientific discipline: Every cell has a plasma membrane, Every electron has a negative charge, Every natural number has a unique successor. By means of generalisation we turn a statement about a particular individual into a statement about a class of entities. Generalisations are essential to valid deductive reasoning. They are the building blocks of virtually every scientific theory, and therefore essential to understanding, explaining, and making predictions.  The most basic and best understood form of generalisation is generalisation over objects (e.g. cells, electrons, numbers). In formal logic, this form of generalisation is achieved via first-order quantifiers, i.e. operators that bind variables in argument position. But many theoretical contexts require generalisation into sentence and predicate positions, a high-level form of generalisation where we make a general statement about a class of statements (e.g. mathematical induction, laws of logic).  There are two competing methods for achieving this form of generality (i.e. higher-order logic and self-applicable theories of truth, properties, and sets respectively). As both methods come with their own ideological and ontological commitments, it makes a substantial difference which one is chosen as the framework for formulating our mathematical, scientific, and philosophical theories.  Some research has been done in this direction but it is still very much in its early stages. This research project will significantly advance this foundational project. It will provide the first sustained systematic investigation of the two methods from a unified perspective, and develop novel formal tools to articulate deductively strong theories. Due to its foundational character, it will ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demonstration Of New Qualitative Innovative Concept of Hydrogen Out of windTurbine Electricity' (2007-2013).

assistant: **Innovation**

The project “Don Quichote” aims at the long-term demonstration of the readiness of the technology of the combination of renewable electricity and hydrogen; facts-based data generated in this project is the base for analysis for further deployment and implementation of combined systems “renewable electricity – hydrogen”. Linked to the technical demonstration emphasis will be put on analysis of regulation, codes, standards, on LCA/LCI, on total cost of ownership and on implementation ways all over Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Striatal Neuron Anatomy and Physiology in Parkinsons Disease'.

assistant: **Objectives**

The basal ganglia are a group of interconnected subcortical nuclei that comprise one of the brain’s fundamental processing units. Striatal circuits lie at the centre of the basal ganglia, and are critical for the performance of the high-level computations required for complex motor and cognitive behaviours. The striatum is composed primarily of projection neurons, but the small proportion of interneurons is highly influential in controlling activity across the structure. Striatal neurons are also the main target of dopaminergic signals arising in the midbrain, the loss of which underlies Parkinson’s disease, a common neurodegenerative disease. Depletion of dopamine in the striatum leads to abnormal network oscillations in the basal ganglia and it has been hypothesized that such activities cause the cardinal symptoms of Parkinson’s disease; rigidity and akinesia. Despite the importance of striatal circuits, the mechanisms by which the different types of striatal neuron interact to support behaviour are not well understood. The overall aim of this project is to define the roles played by different types of striatal neuron in both the normal brain and a model of Parkinson’s disease, with particular emphasis on network oscillations. To achieve this, we will define the in vivo physiological properties of neurochemically- and morphologically-identified striatal neurons, including both projections neurons and interneurons. We will combine this with multi-electrode recordings of large neuronal networks, to effectively account for several levels of functional organization. This multidisciplinary project utilises the coordinator’s proven expertise in the electrophysiology of the striatum, while also offering him an unparalleled opportunity to learn new skills in neuroanatomy, as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding Precancerous changes in BReast CAncer for the development of Therapeutic interceptions' (PreBRCATx), addressing dissemination and exploitation.

assistant: **Impact**

In this programme, we will leverage our understanding of the cellular and molecular changes that precede cancer in high-risk individuals to intercept and prevent the development of the disease. Despite significant advances in immune and targeted therapies, the molecular and cellular complexity of late-stage tumours continues to pose a major barrier to developing a definitive “cancer cure”. This underscores the urgency of identifying those at risk and intervening prophylactically to prevent tumour development. Early detection and interception can significantly enhance the long-term survival of patients. Over the past decade, we have utilised a combination of single-cell genomics, mouse models, and primary human samples to map cellular changes in the breast during homeostasis and tumour initiation. Building on this expertise, we aim to deepen our understanding of precancerous changes driven by BRCA1, BRCA2, and PALB2 mutations, test the efficacy of approved and nearly approved drugs, and develop and test a preventative vaccine in pre-clinical models for these mutations. The PreBRCATx integrated approach is designed to deliver significant impacts for individuals at high risk of breast cancer and, if successful, could serve as a model for other types of hereditary cancers in the future. We aim to gather sufficient evidence to initiate clinical prevention trials, focusing on women with pathological variants of BRCA1, BRCA2, and PALB2 and we anticipate setting up a window of opportunity trial by the end of the programme. The programme will also generate new tools, resources, and data, empowering others in the breast cancer field and benefiting researchers of other solid cancers. Early detection and prevention of cancer could significantly mitigate the socioeconomic impact of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantum Thermodynamics of Mesoscopic Systems' in the context of a Seventh Framework call.

assistant: **Objectives**

This is a multidisciplinary project aiming at bringing together thermodynamics and the physics of quantum mesoscopic systems. Its founding idea is to exploit quantum mesoscopic devices to address fundamental questions of thermodynamics. The unambiguous quantum mechanicaldefinitions of genuinely thermodynamical quantities (such as heat and work) and their use for the construction of thermal engines and heat-transport mechanisms are key points of the project.The analysis of thermodynamical transformations and thermalization processes will be carried out from an information-theoretical perspective, aiming at connecting thermodynamical quantities and concepts of quantum information theory.QTherM will embody a systematic investigation of quantum heat transport in spatially extended quantum many-body systems such as coupled optomechanical cells and atom-loaded optical lattices. A crucial goal of such endeavours will be the thermodynamical characterization of quantumphase transitions in such artificial, quantum-controllable devices.QTherM will constitute the theoretical backbone for a new generation of experiments in mesoscopics, aiming at ascertaining the foundations of thermodynamics through the framework of modern quantum theory. I will collaborate with top-notch theoretical and experimental groups operatingin the areas above to design experimental test-beds for the theory that I will develop.The originality and inter-disciplinarity of the project, the wide spectrum of training objectives that it includes and the highly creative and fertile environment at the proposed host institution will be for me an unprecedented opportunity to reach professional maturity, enrich my scientific background and enhance my career path towards the construction of my own research group.