RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Hierarchical Motif Vectors for Protein Alignment and Functional Classification'.

assistant: **Concept**

This proposal introduces hierarchical motif vectors for numerical analysis of sequence motifs, and develops a novel framework for alignment and functional classification of proteins. Hierarchical motif vectors will be computed using multi-scale decompositions of property sequences obtained by converting amino acid sequences into numeric sequences of various amino acid properties. These hierarchical motif vectors will capture the variations of amino acid properties in the vicinity of each amino acid in the sequence of a given protein. We will develop alignment algorithms for amino acid sequences that match their hierarchical motif vectors. We will also use unsupervised statistical learning algorithms to identify hierarchical motif vectors specific to functional protein groups, notably the antigen binding proteins, transcription factors, growth factors, and glycosylation proteins. We will then apply these methods to protein classification, using the overlap scores from the hierarchical motif vector-based sequence alignment as well as the presence and extent of hierarchical motif vectors specific to the protein group in consideration. We will validate all methods developed in this project against existing sequence alignment, motif detection, and protein classification algorithms in the literature. Among the innovations of the project is the use of hierarchical motif vectors for characterization of local physico-chemical variations along an amino acid sequence. This allows analyzing sequence motifs by general machine learning methods via the embedded vector space arrangement. Next, sequence alignment can be tuned to different amino acid properties at various scales, improving the potential for sequence alignment-based protein similarity in functional classification. Further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of computational and experimental noise assessment and suppression methodologies for the next generation of silent distributed propulsion configurations' in the context of a Horizon 2020 call.

assistant: **Objectives**

Distributed Electric Propulsion (DEP) is particularly attractive from a noise reduction perspective since the induced high frequency noise is associated with: i) increased atmospheric absorption benefiting citizens and ii) improved structural shielding benefiting passengers as well as citizens. SilentProp specific objectives are:-Performing an inclusive testing campaign within a modern and large anechoic wind tunnel configuration. Comprehensive measurements for a wide range of experimental and operational parameters will be delivered for quantifying interactions when adjacent propellers are operating within a DEP system.-Developing a seamless and efficient numerical methodology for providing near field and far field numerical noise computations for DEP configurations nominally identical to the ones experimentally tested. A reduced surrogate modelling approach will also be delivered for accelerating the subsequent optimization procedure.-Experimentally and numerically assessing the effectiveness of established, as well as novel noise suppression technologies including propeller phase blocking for directional sound cancellation and poroelastic, metamaterial and adaptive liners in a variety of configurations. Noise structural shielding by the aircraft structures will also be quantified to evaluate induced disturbance for citizens, as well as passengers.SilentProp will directly contribute to the CS2JU vision of drastically reducing aircraft induced community noise. This will be achieved by delivering key technological advancements to the European aerospace sector that will eventually facilitate the optimal multidisciplinary design and social acceptance for DEP configurations. The Consortium will advance the understanding of key noise aspects involved in DEP systems, enablin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ASSESSING THE IMPACT OF URGENT MEASURES IN PROTECTING AT-RISK DETAINEES  IN LATIN-AMERICA' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Urgent Measures (UMs) are granted by international human rights (HRs) bodies to protect persons in a situation of extreme gravity/urgency. In Latin America, UMs are mostly granted to protect detainees, when their right to life, integrity and/or health are in danger of being violated. When a UM is granted, the state is requested to provide detainees with e.g. immediate access to medical care, drinking water, or sanitation. In such cases, UMs may prompt emergency protective actions that can, in the most extreme circumstances, save the life of the beneficiary of these measures. Though UMs have been issued on thousands of occasions, they have attracted little academic attention. The few studies that exist focus on a doctrinal analysis on compliance. Such studies have several shortcomings in that they primarily examine only procedural legal aspects, and often excessively rely on information provided by HRs bodies themselves. As UMs often face practical, financial and political constraints that shape and limit their implementation, it is crucial to establish a better understanding of how these measures are applied in practice. IMPACTUM moves beyond the traditional legal research questions and methods of analysing UMs. It instead proposes an interdisciplinary study of UMs that: 1) considers the context in which UMs are enforced and how they are applied on the ground; 2) assesses the impacts of UMs on detainees, legal/institutional systems and (inter)national actors; 3) discusses their strengths/limitations; 4) analyses their wider learning effects. With reference to UMs granted by 4 HRs bodies to protect at-risk detainees in 6 Latin American countries, IMPACTUM will develop a critical normative impact framework useful to provide a deeper theoretical analysis, as well as insigh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Quantum fields and knot homologies'.

assistant: **Concept**

This project is concerned with fundamental problems arising at the interface of quantum field theory, knot theory, and the theory of random matrices. The main aim of the project is to understand two of the most profound phenomena in physics and mathematics, namely quantization and categorification, and to establish an explicit and rigorous framework where they come into play in an interrelated fashion. The project and its aims focus on the following areas:- Knot homologies and superpolynomials. The aim of the project in this area is to determine homological knot invariants and to derive an explicit form of colored superpolynomials for a large class of knots and links.- Super-A-polynomial. The aim of the project in this area is to develop a theory of the super-A-polynomial, to find an explicit form of the super-A-polynomial for a large class of knots, and to understand its properties.- Three-dimensional supersymmetric N=2 theories. This project aims to find and understand dualities between theories in this class, in particular theories related to knots by 3d-3d duality, and to generalize this duality to the level of homological knot invariants.- Topological recursion and quantization. The project aims to develop a quantization procedure based on the topological recursion, to demonstrate its consistency with knot-theoretic quantization of A-polynomials, and to generalize this quantization scheme to super-A-polynomials.All these research areas are connected via remarkable dualities unraveled very recently by physicists and mathematicians. The project is interdisciplinary and aims to reach the above goals by taking advantage of these dualities, and through simultaneous and complementary development in quantum field theory, knot theory, and random matrix theory, in collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Joint aviation regulations - translation and elaboration of legislation' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Human factors play a major part in the safety of airlines operations. Implementing Human Factors-related requirements is, however, an extremely difficult issue.The JAR TEL project proposes first to assess the methodology developed in the frame of the NOTECHS JAA/D.G.7 funded project, which aims at evaluating Non Technical Skills, defined in first analysis as the ability of a flight crew member to act in such a way that an optimum level of co-operation, situation management and use of resources and information is obtained". Non technical skills have played an important role in a significant part of the accidents in commercial air transport. The importance of non technical skills in pilot performance is confirmed by the prominent place of Crew Resource Management (CRM) courses in contemporary pilot training. However, while every pilot is trained in CRM skills, no assessment of skills takes place. Recently a survey was initiated by the JAA Project Advisory Group on Human Factors to obtain an overview of research needs that exist in the JAA Member States. Several times an urgent need was expressed to start research into the way(s) the non technical skills of Flight crew members should be evaluated. The new JAA rules laid down in Flight Crew Licensing documents (FCL Part 1, subpart F, para 240) as well as in the operations documents (JAR/OPS subpart N) make such evaluations mandatory.Research is needed to come up with a proposal for a Harmonised application of these rules which could be laid down in an Acceptable Means of Compliance (AMC). The results of the NOTECHS project should be used as a background information for the development of these AMCs. This testing is necessary to validate the proposed method of evaluation, and will be conducted experimentally with a sample of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Open Source Modelling and Hardware Software Codesign of Embedded Systems' (OSMOSIS).

assistant: **Innovation**

Europe has a strong leadership in the domains of intelligent communications, multimedia, and automotive systems. However, the exponential increase in complexity threatens the European competitiveness. Current challenges when designing mixed HW/SW embedded systems are (1) mastering the complexity of the integration between the HW and the SW parts, (2) shortening time-to-market, and (3) reducing design cost. Codesign is the next big step in the holistic ( design of embedded electronic systems; hence it is an essential enabling technology for solving these challenges. It formalizes the interface between the hardware and software parts, and improves the amount of re-use, by allowing one to design models that can be adapted to several different performance/power/cost requirements and to different interface protocols. OSMOSIS will develop a key component required to maintain and enforce the European competitiveness in the intelligent system domains: create an open-source codesign framework for top-down embedded system design. This goal is achieved by joining the numerous on-going efforts in industry and academia into a unified best-practice, industrial-quality framework that will enable an easier transition from research results to industrial exploitation. The OSMOSIS platform will enable experimentation with codesign algorithms, starting from languages such as SystemC and producing HW and SW implementations. The results of the project will have a significant impact on intelligent embedded systems design by promoting cost-efficient software and hardware integration and reducing software/hardware concurrent development time. The consortium mobilizes a significant European force that covers the whole chain of embedded systems design: three embedded system design companies and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elucidating how chromosome cohesion is regulated and established during mammalian meiosis' (2007-2013).

assistant: **Innovation**

Sister chromatid cohesion is essential for proper chromosome segregation. Chromosome cohesion is mediated by cohesin complexes which form a ring-like structure that embraces replicated sister chromatids and hold them together until anaphase onset. Although cohesin binds to DNA dynamically before S phase, cohesion is only established during DNA replication, which requires acetylation of cohesin complexes and subsequent recruitment of Sororin. Sororin promotes cohesion establishment and cohesion maintenance from S phase until mitosis by antagonizing Wapl. Maintenance of chromosome cohesion is extremely important in mammalian meiosis. In oocytes, cohesion establishment occurs during pre-meiotic S phase, which takes place before birth, and then has to be stably maintained until completion of meiosis, which only occurs several months or years later during ovulation. The mechanism responsible for meiotic cohesin stabilization for such long periods of time remains unclear. Notably, the increase of trisomies and other birth defects with maternal age correlates with a gradual loss of sister chromosome cohesion during oocyte maturation. Here, we intend to study how chromosome cohesion is established and regulated during meiosis and to unravel the detailed mechanism responsible for maintenance of sister chromatid cohesion for very long periods of time. We will additionally study how the dynamics of meiotic cohesin complexes affect homologous pairing and meiotic recombination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Humidity Optimisation Tool' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Humidity Optimisation Tool:Outside humidity treatment is a main contributor to aircraft ECS (environmental control system) power requirements. To reduce this power it is needed to know exactly the not to exceed outlet humidity at the pack outlet. Liquid water at Low Pressure ducting participates to cabin cooling but, if this quantity is too high, a fog can be seen.The purpose of the “Humidity Optimization Tool” project is to develop a tool able to predict generation and growth of water fogs in the ECS, in order to avoid them. The project can be separated into three sub-topics:1) Determination by tests of a visibility fog criteria based on physical properties (air speed, liquid water content, blowing temperature, droplet size, etc.)2) Development of a 0D tool to predict the size of the water droplets (liquid or ice) downstream a: (i) Heat exchanger, (ii) Pack outlet turbine and (iii) Mixmanifold3) Validation of this toolThe proper implementation of this research requires two-phase flow expertise in two different fields: (i) numerical modelling and (ii) measurement techniques.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Compartmentalized DNA Computers for In-Vitro Diagnostic Applications' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Changes in human microRNA (miRNA) levels are associated with several important human diseases. Monitoring changes in miRNA levels would enable clinicians to perform diagnosis and evaluate therapeutic efficacy of drugs. In principle, changes in a miRNA signature could be detected by existing methods such as quantitative reverse transcription PCR (RT-qPCR). However, the experimental complexity and computational analysis of the data prevents the measurements of miRNA signatures in a clinical setting. DNA-based molecular computers combine multiplex detection of DNA and RNA strands with molecular computation and are thus able to process and classify miRNA signatures into easy interpretable answers. In my ERC starting grant BioCircuit, we have made a technological breakthrough by compartmentalizing DNA-based molecular computers inside semipermeable micrometer-sized compartments made from a Bovine serum albumin (BSA) polymer conjugate. We have shown that compartmentalization of DNA circuits improves their speed by an order of magnitude and decreases their overall leakiness. Importantly, our work has revealed that this platform is capable of distributed sensing and processing of DNA and RNA strands.In 'DNACom' we will 1) establish the technical proof of concept of compartmentalized DNA computers for in-vitro molecular diagnostics (IVDs) and 2) validate the commercial application of compartmentalized DNA circuits as low-cost, portable point-of-care devices for detection and classification of microRNA signatures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The CLIO consortium: Optimization of Cerenkov Luminescence Imaging for Image-Guided Cancer Surgery' (CLI) targeting Seventh Framework.

assistant: **Abstract**

Cancer is the second largest cause of death and morbidity in Europe, with more than 3 million new cases diagnosed each year. The most effective treatment strategy for most forms of cancer is early detection followed by surgery. However, cancers frequently recur following surgery. For example, nearly 1 in 4 breast cancer patients will see their tumour recur after surgery. The consequences of cancer recurrence include repeat operations, delayed adjuvant treatment, increased likelihood of distant recurrence, poorer cosmetic and functional outcomes, emotional distress, and financial cost. The financial costs are staggering. Europe spends €125 billion annually on cancer care, approximately 5% of which is managing post-surgical recurrence.Tumours recur after surgery primarily due to incomplete excision of the tumour or inadequate clearance of surgical margins. Tumours fail to be completely excised because the surgeon only has the visual appearance of the tumor and palpation to differentiate malignant from benign tissue. Consequently, there is an urgent clinical and market need for improved tools to detect cancerous tissue during surgery.Real-time imaging during surgery would enable the surgeon to more accurately resect tumors and thereby reduce the likelihood of post-surgical recurrence. Cerenkov luminescence imaging (CLI) is a ground-breaking imaging modality that can provide real-time molecular imaging during surgeryThe CLIO consortium will develop a Cerenkov luminescence imaging device and a handheld intraoperative beta particle imaging device for image-guided surgery as well as imaging services for the pharmaceutical and medical device sectors. The imaging services will enable pharmaceutical and medical device clients to improve the efficacy evaluation of pharmaceutical a