RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Silent mutations in cancer' (SILENT).

assistant: **Concept**

Our genome contains 20 000 genes, which are transcribed into mRNAs. These mRNAs are then in turn translated into proteins that exert the cellular functions. In the past decade, researchers have analysed the genetic sequence of all protein coding genes in thousands of tumor samples, with the aim to identify gene defects (‘mutations’) that cause cancer. In most of these studies, only gene mutations that cause amino acid changes in the proteins for which they encode were analysed, and it was assumed that mutations that do not cause amino acid changes (=synonymous or silent mutations) are innocent and meaningless events in cancer pathogenesis. Despite the fact that synonymous mutations have thus largely been ignored by cancer researchers, there are a couple of synonymous mutations that have been shown to promote cancer. This happens via highly novel and poorly understood mechanisms of gene expression dysregulation that occur at the level of gene transcription to mRNA or at the level of translation of the mRNA into protein. Since the role of synonymous mutations in cancer has not been systematically explored so far, and since there is thus evidence that these mutations are not as ‘silent’ and innocent as many people think, we hypothesized that the pathogenic role of synonymous mutations in cancer is largely underestimated. First, we will delineate the landscape of synonymous driver mutations in cancer. For this purpose, we will develop bioinformatics and statistics approaches to identify relevant synonymous mutations in previously generated sequence data from 11 400 tumor samples. Furthermore, we will apply in silico methods to rank identified mutations and filter out the mutations that are predicted to most efficiently promoting cancer. For 50 of the mutations that are pred
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Mechanisms Linking Psychological Stress and Ageing-Related Disease' (STRESSAGED), addressing dissemination and exploitation.

assistant: **Impact**

Ageing-related diseases are the leading causes of morbidity and mortality. A ubiquitous and potentially preventable factor predisposing to their development is psychological stress, but the molecular mechanisms underlying this relation are largely unknown. This knowledge gap is addressed by the proposed project, which examines epigenetic modifications and, in particular, DNA methylation changes as molecular signatures that may be induced by lifetime stressors and act in concert with advancing age to shape disease risk. The proposed fellow will first identify the DNA methylation sites that are regulated by stressors and ageing and will then examine how these epigenomic sites determine gene expression and disease outcomes. Among key biological processes, the project will focus on immune dysregulation, a common pathogenic process for several diseases of the ageing. Immune dysregulation will be examined in the periphery but also in the brain, the orchestrator of behavioral, neuroendocrine and immune responses. The project will engage translational approaches using both human samples and animal models, implemented via collaborations among leading institutions and experts in Europe and USA. The applicant has unique interdisciplinary skills to carry out the project, including clinical background as well as experience in both clinical and basic research projects on the two fields brought together in the proposal, the biology of stress and ageing-related diseases. The impact of the project can be tremendous, since elucidating the molecular mechanisms of ageing-related diseases would contribute to the development of biomarkers, targeted prevention strategies and novel treatments for these devastating diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Space quaLification Of High-Power SSPA based on GaN technology' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Next generation of Guidance Navigation Satellite Systems will require an increase in the available power of navigation signals at the receiver on ground. Current FOC Galileo satellites under development make use of TWTAs to provide an output power of nearly 200W (E1 band). Next generation of Galileo satellites will require higher output powers (2dB more) what implies a challenge in the design and implementation of the high power amplifier unit. Obtaining the required output power levels with certain efficiency and within preset linearity requirements is a key requirement for the optimisation of the payload, which can be satisfied with GaN technology. At L-band efficiency of GaN SSPA in spacecraft is similar to efficiency of TWTAs and it presents as advantage that GaN SSPA requires 2 times smaller area than TWTAs which leads to a 2.5 times lower weight.There are important efforts in Europe focused on demonstrating the capabilities of GaN technology applied to HPAs. Despite of the promising results, the tests are carried out on breadboards. Thus, for real space application it’s necessary to fill the gap between breadboard and final HPA FM, taking into account all the constrains given by space segment: environmental, mass, consumption,…  The aim of SLOGAN project is to evaluate and apply the potentiality of mature UMS European GaN based technology (GH-50) through the realization of a GaN SSPA EQM for the next generation of Galileo satellites. The objective is to make the development for E1 band as it is the most challenging in terms of output power. The development of SLOGAN project will allow not only to show the feasibility of implementing a high output power GaN SSPA for Galileo application, but also will open the door to a wide variety of applications (such as radio br
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'QCIRCLE Center of Excellence: ACCELERATING QUANTUM IMPACT ON SUSTAINABILITY', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

QCIRCLE´s Center of Excellence (CoE) vision is to accelerate the adoption of emerging quantum technologies, enhancing their broad and deep potential benefits. The activity of the CoE will move vertically along the four basic pillars of quantum technology (sensing, computing, algorithms/optimization and communications) and horizontally facing missions where their impact on sustainability is expected to make a difference such as the efficient distribution of energy and monitoring; the high precision sensing and modelling of the evolution of climate change indicators; the development of CO2-neutral transports and industries/agriculture; and early diagnosis and personalized treatments (rare diseases, neurological conditions, or cancer). QCIRCLE CoE will be settled in the Canary Islands (outermost Spanish region) and emerges to become a triple-crown winner in quantum science becoming a reference as a quantum educator, a quantum research hub, and a quantum innovation hub to make sure quantum technology reaches society and markets. For this, QCIRCLE CoE will mobilize the Canarian R&I ecosystem and will establish solid long-term high-level research, knowledge-transfer and innovation partnerships with the counterparts (Advanced Partners, AP) from ULM University, reference centre for Quantum Sensing and Quantum Optics (Germany), Quantum Technologies Platform at  Research Council, reference centre for Quantum Algorithms Communications (Spain), the Institute for Quantum Optics and Quantum Information (IQOQI) of the Austrian Academy of Sciences (Austria), and Quantum Technology Hub at University of Birmingham, reference centre for quantum metrology and applications.The CoE will attract international expertise and investment and will act as a springboard for exporting Canarian/Spanis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A holistic approach to training a new generation of scientists in marine biodiscovery' (HOTBIO) targeting Horizon Europe.

assistant: **Abstract**

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A coherent approach to analysing heterogeneity in network data'.

assistant: **Innovation**

The overarching goal of this project is to develop a coherent set of econometric methods to deal with unobserved heterogeneity in the analysis of social interactions between agents. Such heterogeneity is well recognized to be important. It is often of great interest to document the degree of heterogeneity, evaluate its impact, and uncover the existence and form of any complementarities that may exist between agents. With the growing availability of network data, questions of this kind are increasingly being asked in applied work. The development of appropriate econometric tools to answer them has, however, not followed suit. If anything, recent theoretical work has pointed at substantial difficulties with the so called fixed-effect approach currently serving as the workhorse tool. This project recognizes the potential of taking a random-effect view. For settings where agents interact in pairs, such a view has received some attention in the literature. However, to date, it struggles with issues of identification, estimation, and computation. We will develop a new nonparametric approach that provides a solution to each of these three issues. We will next venture forward and extend this framework to situations where agents interact in larger groups. Both collaborative and non-collaborative settings will be considered, thereby covering team production, competition, and peer effects. Special attention will be given to recovering treatment effects in the presence of social interactions, where interference on unobservable confounders is an issue. For situations where data limitations prevent a fully nonparametric approach, instrumental-variable methods that build on flexible functional form restrictions will be developed. The statistical properties of the proposed estimators w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Evolutionary origin and impact of germline-restricted chromosomes'.

assistant: **Objectives**

Many multicellular organisms have a division between germline and soma. It has been long-standing dogma that all these cells have the same genome as they develop from a single cell. However, programmed DNA elimination can remove DNA during germline–soma differentiation and thereby lead to dramatic differences in genome organization between tissues. The evolution and function of programmed DNA elimination remains mysterious due to technological limitations and lack of an evolutionary framework. However, a role of this phenomenon in minimizing germline–soma genetic conflict has been suggested. This conflict arises when developmental gene expression is beneficial for the germline but deleterious for the soma.The aim of this proposal is to test whether programmed DNA elimination allows germline-specific expression of developmental genes to minimize germline–soma conflict. Using the germline-restricted chromosome (GRC) of the zebra finch as a unique study system, I have recently pioneered high-throughput genomics to overcome previous limitations. Combining my novel approach with transcriptomics, proteomics, cytogenetics, and developmental and functional genomics will provide unprecedented insights into the evolution and function of germline–soma genome differences.First, I will establish the so far first GRC study system by generating a zebra finch GRC reference assembly. Second, I will test how the GRC is inherited and maintained in zebra finch populations. Third, I will elucidate the long-term evolutionary history of GRCs across songbirds to reveal genes that are most conserved and thus candidates for GRC function. Fourth, I will trace GRC expression and elimination across zebra finch development, and functionally validate candidate genes. Altogether, I will establish an e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'TSE spiking experiments for process validations: evaluation of different sources of infectivity and spiking approaches' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

SUMMARY In this proposed research project, we want to concentrate on existing weaknesses of validation processes: infectious material used for spiking should always be close to the real situation, but is usually crude brain extract of infected animals because of its high titre. This is, however, in many cases quite different from natural infection, especially if we consider blood products. We therefore want to use different infectious preparations, including suspensions of infected neuroblastoma cells, to spike plasma and simulate the industrial process of plasma fractionation, concentrating on the 3 major fractions containing clotting factor Vlll, IgG and albumin. If a product is made in a multi-step process, consisting of several inactivating steps, each of these steps can be challenged in a spiking experiment and the overall reduction of infectivity can be calculated as the product of the inactivation results of the individual steps. This is valid, however, only, IF the steps are different (employing different modes of inactivation/removal) AND if the units of infectivity are truly independent entities. In the case of TSE this is doubtful, due to the very hydrophobic nature of their agents, leading to self-aggregation. To test this, we want to perform a 3 step - process twice: First, the infectious spike is added to the starting materials of all 3 steps, these steps are validated individually and the overall reduction of infectivity is calculated; Secondly, infectious material is added only to the starting material of step 1, and the 3 steps are performed consecutively, using this material. The final product's infectivity is determined and compared to the calculated result of test 1. We also want to evaluate existing (western blot) and emerging (DELFIA) IN VITRO ASSA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Out-of-equilibrium dynamics of spatially confined Hamiltonian systems.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The EDYSC project aims to establish the foundations of a theory of out-of-equilibrium dynamics of spatially confined waves. To this end, the project will use the Wave Turbulence theory as a reference point, which is well-established for the description of out-of-equilibrium dynamics of weakly interacting (unconfined) waves. The research program will study how spatial confinement affects some of the most characteristic processes of Wave Turbulence such as propagation of chaos, thermalization, or energy transfer. It will be done by considering the influence of the discrete nature of resonances between waves (characteristic of spatially confined systems) on these processes. This study will characterize the principles that a theory of out-of-equilibrium spatially confined waves must follow. This proposal lies in the interphase between various areas of nonlinear physics and mathematics, having an interdisciplinary interest, both theoretically and experimentally. The effects of discrete resonances on the dynamics of confined systems have been observed in disparate topics, such as nonlinear optics, Bose-Einstein condensates, gravity waves, general relativity, etc. These effects range from preventions of thermalization in light propagation in optical fibers to even the formation of arbitrarily small black holes. This wide range of applicability will be used to build synergies between the theoretical results of the project and experiments conducted by other groups.The methodology uses a hybrid approach, based on numerical methods to get insight into the heart of the problems followed by its analytic description. To this end, the project will study a family of spatially confined systems with excellent analytic properties, the so-called highly resonant Hamiltonian systems. These s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dissecting quantitative traits and their underlying genetic interactions via systematic genome editing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Despite the ubiquity of genome sequence data, unravelling the contributions of genetic variation to phenotypic diversity remains one of the greatest challenges in genomics. This is partly due to our very limited knowledge of how multiple variations combine to create phenotypes. There is a clear need for a systematic, perturbation-based approach to study the phenotypic consequences of genetic variants in different genomic and environmental contexts. Previous efforts have primarily used loss-of-function or overexpression approaches, but it is known that subtle, naturally occurring variants have the most relevance for complex, quantitative traits. Our proposal aims to dissect these effects by systematically engineering and functionally profiling naturally occurring single-nucleotide variants (SNVs) and small insertion/deletion polymorphisms (indels) in the S. cerevisiae species in three diverse genetic backgrounds. To generate such an unprecedented collection, we will apply a high-throughput CRISPR approach that allows rapid isolation of sequence-verified strains. DNA barcodes integrated into the genome of each strain will enable pooled, competitive growth, which will reveal how variants modulate fitness as a function of environment and genetic background. We will test our collection for pairwise and higher order interactions, assay their impact on cellular processes and dissect pleiotropic roles of highly connected genes. Our work will circumvent the key limitations in current high-throughput genome editing screens and enable the largest interrogation of the functional impact of genetic variation in different environmental and genetic contexts to date. The combined insights and tools generated by our work will aid in developing predictive models of the effects of genetic