RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional imaging during X-ray interventions' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The overall aim of this multidisciplinary project is to train five early stage researchers in the exciting and relevant field of medical imaging, and to close a technology gap in interventional radiology. Training will be provided in various inter-related disciplines, including X-ray and imaging physics, numerical mathematics, engineering disciplines, and interventional medicine.The technical objective of the project is to develop and exploit basic and application-specific methods for tomographic X-ray imaging, with the vision of improved medical treatment procedures in interventional medicine in Europe. In particular, the project aims at making currently unavailable quantitative information on physiological parameters, such as arterial blood flow and brain tissue perfusion, accessible during X-ray interventions. A second major technical objective is to enable interventional tomographic X-ray imaging of fast moving objects such as the human heart. Availability of such imaging capabilities is expected to significantly improve planning, guidance, and outcome control of existing and future minimal-invasive medical treatment procedures.The fellows will be fully integrated into a cluster of existing, strongly collaborating projects, comprising more than 20 highly skilled researchers working in the field of tomographic X-ray imaging. The fellows will benefit from an extensive European research network, offering close cooperation with eight universities and four clinical training partners. The proposed programme has a potential impact on future medical products and will thus strengthen the competitiveness of the European medical systems industry. The fellows will have ample opportunities to contribute to and participate in activities of the scientific community. The training p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Default and Collateral in Financial Markets'.

assistant: **Objectives**

The main objective of this project is to research the economic implications of default and collateral in financial markets. It is motivated from the observation that much of the lending in modern economies is secured by some form of collateral and by the empirical fact that modern economies experience a substantial amount of default and bankruptcy. From a theoretical perspective, the research aims to explore new ways of modelling default and collateral and employ them to evaluate the impact of default and collateral on market outcomes. From a policy recommendation perspective, the research aims to develop models with testable implications that can be used by practitioners to discuss the consequences of a wide range of policies. In particular, to explore which kind of regulation procedures should be implemented in order to lower the risk of default and at the same time not to reduce too much risk-sharing. The agenda includes two research directions. The first research direction will focus on the implications of default and collateral in economies with bounded rational agents. Our aim is to understand how default and collateral affect market outcomes in environments where agents are allowed to have very divergent and therefore possibly incorrect beliefs about endogenous economic variables like future prices and delivery rates. The second research direction will focus on the implications of default and collateral in economies with an open ended horizon. Our aim is to investigate endogenous debt constraints that are compatible with equilibrium and simultaneously allow for as much risk sharing as possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multiresolution in geometric modelling' (1998-2002) under Fifth Framework.

assistant: **Objectives**

All aspects of multiresolution techniques in geometric, namely their theoretical underpinning in mathematics, their algorithmic realizations in computer science, and their applications in engineering, are under extremely rapid development. Building up the necessary knowledge base and reaching a sufficient level of competence in these areas has therefore become a daunting task for young researcher. University courses often tend to be too rigidly organized to provide training in the newest research ideas and latest developments in industry. The network group, however, can offer a timely exposure to state-of-the-art techniques in this research area. Young researchers will thus acquire expertise that will make them sought-after specialists in a highly attractive area of information technology. The joint activities of the training programme will include lecture series, a summer school, two workshops, short-term exchange visits, and the management of a common software database.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Novel Alpha-Helix Mimetics as Anti-Cancer Leads'.

assistant: **Objectives**

Breast cancer is the most common cancer in women in the western world, and 80% of breast cancers express the estrogen receptor (ER). Whilst inhibitors of ER action such as Tamoxifen and inhibitors of estrogen biosynthesis (e.g. aromatase inhibitors such as Anastrozole) have contributed to reductions in breast cancer mortality, resistance to these agents is a major problem. Such resistance could potentially be minimised by switching therapy with endocrine agents and as such there is an urgent clinical need to identify potent inhibitors of novel targets focused on countering endocrine resistance.Liver receptor homologue 1 (LRH-1) is a nuclear receptor (NR) protein whose transcriptional activity is critical for aromatase expression in tissue surrounding the tumour. Moreover, LRH-1 also directly regulates breast cancer cell growth acting in concert with ER. Development of selective LRH-1 inhibitors would therefore provide a potent means of inhibiting ER activity in breast cancer cells, by direct down-regulation of ER levels and prevention of its activation by inhibiting local estrogen biosynthesis.In this project, we plan to develop selective LRH-1 inhibitors by synthesising small molecule Coactivator Binding Inhibitors (CBIs) that will block the protein-protein interaction between LRH-1 and its coactivator proteins (e.g. SHP-1). This interaction is an obligatory prerequisite for transcriptional activity. The critical binding interface comprises an alpha-helical secondary structural motif presented on the surface of the coactivator and a complimentary surface exposed groove in the AF-2 domain of LRH-1. Five key residues on the alpha-helix are required for potent and selective binding. Thus the molecules we will prepare by organic synthesis and evaluate initially in both FRE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EXploring Chemistry, Composition and Circulation in the stratosphere with Innovative TEchnologies' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

It is ozone that primarily heats and therefore creates the stratosphere. Human emissions of ozone-depleting substances (ODSs) have however led to dramatic stratospheric ozone losses for decades. This global problem is ongoing and of renewed concern due to recent unexpected changes. It is also likely affecting the nature of the stratosphere itself, with implications for global health and economy. In addition, emissions of greenhouse gases have been proposed to lead to a long-term acceleration of the stratospheric overturning circulation. In summary, significant stratospheric changes are to be expected from both, ozone losses and global warming.Indications for such changes have been reported, but there are substantial uncertainties and limitations connected with these studies. In addition, current technologies to explore stratospheric composition and chemistry are very expensive and often offer only infrequent data. There is clearly a need for new and improved tools to correctly detect and quantify changes from observations.This project will open 3 novel avenues to explore stratospheric chemistry, composition and circulation:1) A newly developed low-cost technology to retrieve and analyse air from the stratosphere. This will be a new way to derive budgets of all important and newly emerging ODSs directly in the stratosphere; while at the same time providing observations of many strong greenhouse gases.2) I have found new evidence for substantial past changes in stratospheric chemistry and circulation. An unprecedented investigation of stratospheric air archives spanning 40 years and >50 trace gases will allow new insights into these changes 3) New diagnosis tools and a detailed comparison with state-of-the-art models will identify the implications for future climate.The E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SKILLS FOR LABOUR MARKETS IN THE GREEN AND DIGITAL TRANSITION' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The project SkiLMeeT (Skills for labour markets in the digital and green transition) has three main objectives: 1)generate data and indicators which quantify the extent of labour and skills shortages and mismatch in Europe;2)explore the drivers of these gaps and shortages, with a focus on the digital and green transitions;3)analyse and identify pathways to reduce skill gaps and shortages.SkiLMeeT advances the knowledge how the work programme’s main goals can be achieved: to equip the workforce with the demanded skills, to encourage successfully the necessary reskilling and upskilling of the workforce and ultimately to realise the full potential of the digital and green transitions for Europe as a whole.To achieve these aims, SkiLMeeT builds on an inter- and transdisciplinary approach bringing together quantitative and qualitative methods. The combination of in-depth case studies and broad analyses of European economies using a rich variety of data sources ranging from survey and administrative data to big data provides highly valuable complementary insights into the nature of shortages, their drivers and pathways out. The indicators created are transparent and easily accessible. The analyses of drivers and pathways are conducted both for all European countries and for particularly relevant example countries.To validate the quantitative analyses, to explore mechanisms and to identify particularly promising pathways, we engage in extensive consultations and set up feedback loops with the research community, especially with relevant international and national research initiatives, and with stakeholders. The stakeholder consultations help to develop concrete policy proposals aimed at a thriving economy and an inclusive society. To maximise SkilMeeT’s impact, we disseminate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Spring school on regenerative medicine' in the context of a Sixth Framework call.

assistant: **Objectives**

Five European groups from five countries with an excellent reputation of clinical, clinical-experimental and basic research in the field of human adult and embryonic stem cells will jointly form over 48 months a regular Marie Curie conference with training courses. This will help to realize a stable European forum for regenerative medicine, with the focus on neuronal stem cell research. These meetings will bring stem cell researchers, biotechnology companies and financing sources together.The meetings will allow to discuss latest developments within in vivo and vitro stem cell differentiation, and will give the opportunity to the participants to learn the latest news in the areas of how to stimulate endogenous stem cells, how to modulate signalling in stem cells, how to modify these signals for standardized differentiation and how to translate this information together with the biotech industry as a translational process. Additionally, a practical lab course on the most important experimental technologies will be offered. Active and outstanding students and young post-doc scientists can send their application for 20 positions of the practical lab. The participants will also be able to perform their own experiments, in small groups, under the supervision of qualified and experienced staff. Special attention will be given to practical aspects and various pitfalls, as well as basic design of technical procedures.The course is thought to teach the scientist to write an experimental protocol as a combination of their own skills and the methods they are learning during the lab course. The RegMedTeach programme will enable and encourage young scientists to plan and execute their own experiments in the field of neuronal stem cell technology. The conference will have a long-term
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Genes and proteins of meiosis in arabidopsis and brassica'.

assistant: **Innovation**

The aim of this proposal is to develop a novel route to the isolation and characterisation of meiotic genes from higher plants. This will exploit the progress made in the analysis of Arabidopsis and Basic meiosis, together with developments in polemics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Observing the Mechanisms of Earthquake Nucleation' (OMEN), addressing dissemination and exploitation.

assistant: **Impact**

Earthquakes are one of the most expressive phenomena of our planet, able to suddenly reshape the surface of the Earth and affect countless lives every year. Any effort towards earthquake forecast and hazard mitigation must rely on a profound comprehension of seismogenesis. However, earthquakes are phenomena that emerge from a complex, dynamic system of mechanisms that operate at inaccessible depths within the Earth. The impossibility to directly observe the birth of an earthquake (i.e., the “nucleation”) frustrates our effort to have new breakthroughs on their physics.The overarching goal of OMEN is to directly observe the mechanisms of earthquake nucleation to allow for a step-change in our understanding of seismic slip and its potential precursors. OMEN will overcome the current experimental approaches that rely only on the indirect measure of sample properties and/or use of rock-analogue materials. With an innovative rock-deformation apparatus and the use of transparent high-tech glass, I will be able to simulate and, for the first time, film the birth of earthquakes in natural fault rocks at hypocentral conditions. This method, in combination with several investigation techniques (visible and infrared footage, acoustic emissions, deep learning-assisted image analysis etc.), will offer unprecedented detail on the processes during the preparation and propagation of seismic slip. In particular, I will shed new light on how the complexity of natural rocks affect the dynamics, resulting into the formulation of a new, more reliable physical framework for the description of earthquake nucleation. Laboratory and theoretical results will be upscaled to nature thanks to the integration of microstructural and field studies of natural faults. OMEN is the unique opportunity to o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Enabling knowledge for disaster risk reduction in integration to climate change adaptation' (KNOW-4-DRR), addressing dissemination and exploitation.

assistant: **Impact**

“Mobilizing knowledge” suggests that there is need to dynamize the context in which knowledge about risks is developed, shared, and maintained. It conveys the implicit assumption that knowledge is perhaps currently fragmented and stuck in different compartments and bodies, be they institutions, agencies, universities, research centres, communities, individuals.While with this proposal we fully agree with this assumption, we think it is time to abandon the idea of a “knowledge transfer”, as a good that can be moved from the scientific arena into policy making or into administrative practices. The questions that we wish to ask are who should know what, who actually knows, and if knowledge produced in various ways and fields is effective in achieving disaster risk reduction and climate change prevention and adaptation.Three issues seem particularly relevant to explore:- Fragmentation and separations of arenas (i.e. Scientists, Public and private agencies or organizations in the field of prevention)- Changes that have occurred in risk knowledge management strategies overtime- Knowledge management about risk in times of crisis.The main objective of this proposal is to frame a knowledge management system for disaster risk reduction and climate change adaptation that may be considered as a comprehensive reference for establishing, reinforcing, or revising current prevention, mitigation and adaptation strategies. Such knowledge system will embody what has been achieved in different arenas and by different social groups in the field of prevention, preparedness and adaptation.In order to do so, a circular process between scientific and technical analysis and dissemination will be developed, so as to make use of a wider expertise and reach a larger audience. We want to use some of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of artificial phosphoinositides aiming at HIV eradication' (Super-HIPPO) targeting Horizon Europe.

assistant: **Abstract**

Main challenge of fighting with the HIV is to eliminate the latent viral reservoir from the body. This reservoir is resistant to antiretroviral drug therapy and can cause viral rebound if the treatment is stopped. The removal of the reservoir enables HIV eradication, is urgently desired in HIV-AIDS research. For this purpose, a strategy called “kick and kill” was proposed, based on the hypothesis that activation of latent HIV (“kick”) leads to cell death (“kill”) by physical damage and/or immune activation. However, in clinical tests “kill” process was found to be not enough to reach HIV eradication.               To eradicate HIV from the body, my work has recently suggested a new strategy called “lock-in and apoptosis” instead of “kick and kill”. In development of this strategy, non-natural derivative of inositol hexaphosphate (IP6) named as L-HIPPO was designed based on the fact that the MA domain of Pr55gag which mediates membrane binding through its interaction with inositol phospholipid PIP2 in the host membrane. L-HIPPO was administrated to HIV infected HeLa cells as complex with a carrier α-CDE and suppressed membrane localization of HIV-1 Gag protein and induced strong apoptosis of the host cell containing the latent viruses. In contrast, α-CDE-L-HIPPO induced less apoptosis on T cell line. Besides, the complex of α-CDE-L-HIPPO is inapplicable for oral use. Toward this end, new L-HIPPO derivative with alternative carrier is required.               An ultimate goal of this work is to develop new L-HIPPO derivative (Super-HIPPO) with more potent and efficient activities. My objectives to reach this goal are (1) to synthesize new L-HIPPO derivatives and alternative carriers, (2) to evaluate their activities, (3) to repeat design, synthesis and biological evaluatio