RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Control of meiotic recombination: from Arabidopsis to crops'.

assistant: **Objectives**

Global population stands at 7 billion and is predicted to reach 9 billion by 2050. It is anticipated that food production will need to increase by at least 50% to meet the demand arising from this increase in population. This will require a sustained improvement in crop yield. The nature of this challenge is exacerbated by the likely impact of climate change. These factors combine to make Food Security one the key challenges for the 21st century. To deliver improvement and sustainability in crop production it will be necessary to harness a broad spectrum approaches. Crop improvement will be crucial and a major part in the delivery of this will be based on classical breeding. This harnesses the genetic variation that is generated by homologous recombination during meiosis. Meiotic recombination creates new combinations of alleles that confer new phenotypes that can be tested for enhanced performance. It is also crucial in mapping genetic traits and in the introgression of new traits from sources such as wild-crop varieties. Despite the central role played by meiosis in crop production we are remarkably ignorant as to how the process is controlled in these species. For example, it is not known why recombination in cereals and forage grasses is skewed towards the ends of the chromosomes such that an estimated 30-50% of genes rarely, if ever, recombine thereby limiting the genetic variation that is available to plant breeders. Moreover, as many crop species are polyploid a further level of complexity is added to the meiotic process. Over the past 15 years studies in Arabidopsis, many conducted in the laboratories in the COMREC consortium, have provided both insights into the control of meiosis in plants and generated the tools to analyze this process in crop species. It is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Strong Convex Relaxations with Optimal Approximation Guarantees'.

assistant: **Objectives**

One of the most exciting areas of theoretical computer science is to understand the approximability of fundamental optimization problems. A prominent example is the traveling salesman problem, for which a long-standing conjecture states that a certain algorithm gives a better guarantee than current methods can prove. The resolution of this conjecture and of many other fundamental problems is intimately related to an increased understanding of strong convex relaxations.Although these problems have resisted numerous attempts, recent breakthrough results, in which the PI has played a central role, indicate new research directions with the potential to resolve some of our most exciting open questions.  We propose three research directions  to  revolutionize our understanding of these problems and more generally of the use of convex relaxations in approximation algorithms:(I)  develop new approaches to analyze and harness the power of existing convex relaxations;(II) understand the power of automatically generated relaxations; and(III) prove the optimality of algorithms based on convex relaxations.The proposed research lies in the frontier of approximation algorithms and optimization with connections to major problems in complexity theory, such as the unique games conjecture. Any progress will be a significant contribution to theoretical computer science and mathematical optimization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multidimensional nmr studies on the structure, dynamics and molecular recognition of mge1p, a mitochondrial homologue of e. coli grpe' in the context of a Fourth Framework call.

assistant: **Objectives**

The three-dimensional structure of the recombinant Mgelp protein, which is a first mitochondrial homologue of the E. Coli GrpE protein, will be determined by the multidimensional heteronuclear NMR spectroscopy using the 15 N and 13 C labelled protein samples. Mgelp consists of 196 amino acids and belongs to the heat shock proteins of the Hsp70 chaperone family that is responsible for folding and assembly of proteins, transcription, protection against heat, and translocation of proteins across intracellular membranes. The dynamic properties of the protein will be obtained from the 15 N and 13 C relaxation measurements. The binding site of Mgelp with mt-Hsp70 and its smaller peptide fragments will be mapped by monitoring perturbation of line widths and chemical shifts of the 15 N labelled Mgelp resonances during titration with unlabeled mt-Hsp70 and its peptides. The change of the conformational flexibility of the binding regions upon complexation with small peptides will also be studied. As no structural information exists on the Mgelp and GrpE proteins, the proposed study, together with biochemical experiments, should serve as foundation for a better understanding of these protein-protein interaction .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NEW_InnoNet: The Near-zero European Waste Innovation Network' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Europe generates around 3 billion tonnes of waste yearly, which is expected to grow further. Despite the introduction of innovative waste and recycling technologies, market uptake varies drastically amongst the 27 Member States.New-InnoNet is the new stakeholder platform initiative by 12 European consortium members active as entrepreneurs, researchers and policy makers. These recognise that in order to reach a European near zero waste economy, all value chain stakeholders must cooperate, exchange generated knowledge, insights and hands-on experience and enforce changes to the value chain structure together. Previous initiatives were unable to achieve actual, large scale results towards a sustainable growth of the European economy. The reason is that they either focussed on a  specific waste area or they lacked the involvement of the competent industries. This project includes various waste value chains which enable exchange of information and technology transfer from one chain to another. In addition, the consortium’s network includes over 2000 relevant industrial stakeholders and several already expressed their interest in this new stakeholder platform, its goals and actions. During the project, key stakeholders will be mobilised to participate in the platform and road mapping workshops, as only an active involvement of industrial organisations will lead to the desired changes in the structure of the value chain. The many letters of support show the consortium's strength in mobilising stakeholders.NEW_InnoNet’s main objective is to mobilise stakeholders towards building a circular economy by developing and reinforcing solid foundations for building the European Near-Zero Waste Platform through: 1. Set-up and maintain near zero waste stakeholder platform2. Analyse selec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Cluster pilot project for the integration of res into european energy sectors using hydrogen (RES2H2)'.

assistant: **Innovation**

The main objective of the proposed project is the integration of RES, hydrogen production and utilisation into energy sectors. This will be done by designing, constructing and evaluating self sufficient energy systems driven by wind energy, capable of generating hydrogen, electricity and water making use of the features of hydrogen as an energy vector. Systems of this kind could be implemented in the near future in any area with high renewable (wind) energy potential for pure hydrogen production and commercialisation as well as electricity and water demand coverage (renewable energy and water independent grids).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A new superconducting detector for x-ray astronomy' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content We propose a new design of high energy resolution detectors for X-ray astronomy. An array of sub-millimetric-sized superconducting devices, which define a position resolution better than l50um, cover the detector area (several square centimetres). Photons are absorbed in such devices, and detected by measuring the excess of quasi-particles created. Quasi-particles are trapped in a tungsten thermometer where they loose energy, increasing the temperature of the electron bath. The tungsten thermometer, operating near the superconducting transition temperature (Tc=l5mK) transforms the temperature increase into a rise in resistance. Taking advantage of the fast quasi-particle diffusion in the absorber and the low heat capacity of the thermometer, we believe that an energy resolution high as lOeV, which is at least a factor ten higher than the best silicon-based detectors, can be achieved. The development of small cryogenic refrigerators, reaching temperatures as low as 5mK, will allow these detectors to be used in space. Training content (objective, benefit and expected impact) Training on dilution refrigerators and instrumentation electronics will be necessary. In particular, the achievement of a low baseline electronic noise is needed in high-energy resolution detectors. Links with industry / industrial relevance (22) Although no direct links with industry are involved in this proposal, the development of high- resolution X-ray detectors is of strong interest to industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Theranostic platform for early diagnosis and treatment  of cancer based on Acoustofluidics'.

assistant: **Innovation**

This proposal develops a pioneering microscale ultrasound-based system to enrich extracellular vesicles (EVs) from µL volumes of whole blood and cancer spheroids, targeting early cancer detection and revolutionizing therapeutic approaches.EVs, nanoscale particles (30-1000 nm) released by mammalian cells, hold potential as biomarkers for cancer detection and as drug delivery vehicles due to their cell-specific cargo and ability to penetrate cell membranes. However, current isolation methods like centrifugation are time-consuming, require large sample volumes, and lack purity and scalability, limiting clinical application, particularly in high-throughput biomarker discovery and therapeutic development.I propose to overcome these critical barriers through the creation of TheraSonic, a disruptive acoustic force-based microfluidic platform that leverages a novel particle trapping effect in bulk volumes. TheraSonic will enable the unprecedented enrichment of EVs from µL biofluid samples, offering transformative improvements in purity, scalability, and throughput. By integrating spheroid culturing and multi-omics, this platform will reveal insights into cancer heterogeneity.Moreover, TheraSonic uniquely enables the selective isolation of EV subpopulations based on size, surface markers, and acoustic properties. This unprecedented resolution will uncover highly specific cancer vesicle profiles that current methods fail to detect, leading to the discovery of highly sensitive and specific cancer biomarkers.The scalable nature of the platform will be harnessed to significantly increase capacity and throughput, providing needed EV material for novel autologous EV therapies. Combined with organ-on-a-chip technologies, it will facilitate the development of individualised cancer treat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Active Mechanisms of Cell Selection: From Cell Competition to Cell Fitness.' (CELLFITNESS) targeting Seventh Framework.

assistant: **Abstract**

The molecular mechanisms that mediate cell competition, cell fitness and cell selection is gaining interest. With innovative approaches, molecules and ground-breaking hypothesis, this field of research can help understand several biological processes such as development, cancer and tissue degeneration. The project has 3 clear and ambitious objectives: 1. We propose to identify all the key genes mediating cell competition and their molecular mechanisms. In order to reach this objective we will use data from two whole genome screens in Drosophila where we have identified 7 key genes. By the end of this CoG grant, we should have no big gaps in our knowledge of how slow dividing cells are recognised and eliminated in Drosophila. 2. In addition, we will explore how general the cell competition pathways are and how they can impact biomedical research, with a focus in cancer and tissue degeneration. The interest in cancer is based on experiments in Drosophila and mice where we and others have found that an active process of cell selection determines tumour growth. Preliminary results suggest that the pathways identified do not only play important roles in the elimination of slow dividing cells, but also during cancer initiation and progression. 3. We will further explore the role of cell competition in neuronal selection, specially during neurodegeneration, development of the retina and adult brain regeneration in Drosophila. This proposal is of an interdisciplinary nature because it takes a basic cellular mechanism (the genetic pathways that select cells within tissues) and crosses boundaries between different fields of research: development, cancer, regeneration and tissue degeneration. In this ERC CoG proposal, we are committed to continue our efforts from basic science to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Resistant wild potatoes as source for novel genes mediating resistance against fungal, viral and nematode diseases' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Improving the resistance of crops to diseases caused by viruses, fungi and nematodes is a major priority of agriculture. Current protection strategies based on extensive use of chemicals are considered untenable for sustainable agriculture due to negative impacts on the environment. Genetic engineering proved to be able to successfully overcome these problems by improving natural resistance of plants. However, the achieved protection levels are not yet sufficient for commercial use of the plants. Improvements are possible by using proteins with higher anti-viral, anti-fungal and or nematicidal potential. Therefore, the project aims at the investigation of resistant wild Solana species and at the identification of novel resistance mediating proteins and genes, useful to create resistant transgenic crop plants.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Manipulating single fermions with light in cQED architectures' under Horizon 2020.

assistant: **Concept**

FERMIcQED aims at interfacing novel quantum materials with microwave light at the level of the single photon and fermion. To achieve this ambitious goal, I plan to use low-dimensional quantum conductors  such as carbon nanotubes or semiconducting nanowires  combined with state-of-the-art architectures and techniques of circuit Quantum Electrodynamics. The idea consists in isolating an individual fermionic degree of freedom within a hybrid Josephson junction  a quantum dot connected to two superconductors. Due to the superconducting proximity effect, entangled electron-hole states  called the Andreev bound states  form in the quantum dot and depend on the superconducting phase difference. By enclosing the hybrid Josephson junction inside a superconducting photonic cavity, one can couple these fermionic states to microwave light and probe their quantum properties in a well-controlled environment.Specifically, FERMIcQED will tackle three key experiments. First, we will detect the spin degree of freedom of the Andreev bound states and manipulate it coherently as a superconducting spin qubit. We will demonstrate strong coupling with cavity photons, which will enable quantum logic operations and long-range qubit interactions. Second, we will operate the hybrid Josephson junction in the topological regime in order to observe and manipulate Majorana fermions, thus implementing a topological qubit. At last, we will probe the joint entangled dynamics of bosonic and fermionic modes that coexist in hybrid Josephson junctions and simulate the spin-boson problem.


**Keywords:** Hybrid quantum circuits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthesis of Low Noise Microwaves Using Solitons Locked to an Ultra-Stable Cavity' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project (SOLISYNTH) aims to utilize the novel crystalline microresonator optical frequency comb to synthesize ultra-stable microwaves. The microresonator comb will operate in the state of temporal dissipative soliton and an ultra-stable Fabry-Perot cavity will be used as a reference for the comb to lock to. By using direct optical division with the comb, this work could offer a new approach to synthesize low-phase-noise microwaves in a compact form factor, which could have applications in Radar, timing and telecommunications to radio astronomy. In addition, this project seeks to generate mid-infrared soliton comb with octave spanning bandwidth through dispersion engineering and quantum cascade laser pumping. With its exceptionally high coherence, such frequency comb offers access to the molecular fingerprinting region where many chemical species show distinctive absorption features. Devices based on this research output can find tremendous applications in mining, agriculture and medical diagnosis.Due to the prominent values of the research on microresonator comb, there are many groups in the US delved into this field, and the numbers of publications and filed patents on this topic has been rising rapidly. Hence this project will not only enhance Europe’s position in scientific competition with US, but also gain substantial economic benefits through strengthened industrial innovation. On the other hand, the host group in EPFL will consolidate its leading position in the field by integrating the applicant’s knowledge and experience on ultra-stable cavities and laser stabilization with the soliton comb research, thus facilitating both the fundamental investigation and the commercial development based on the microresonator frequency comb. Moreover, the applicant will a