RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Crystal channeling to extract a high energy hadron beam from an accelerator'.

assistant: **Concept**

A new generation of parasitic beam extraction of high energy particles from an accelerator is proposed in CRYSBEAM. Instead of massive magnetic kickers, bent thin crystals trapping particles within the crystal lattice planes are used. This type of beam manipulation opens new fields of investigation of fundamental interactions between particles and of coherent interactions between particles and matter. An experiment in connection to Ultra High Energy Cosmic Rays study in Earth’s high atmosphere can be conducted.Several TeV energy protons or ions are deflected towards a chosen target by the bent lattice planes only when the lattice planes are parallel to the incoming particles direction.The three key ingredients of CRYSBEAM are:- a goniometer based on piezoelectric devices that orients a bent finely-polished low-miscut silicon crystal with a high resolution and repeatability, monitoring its position with synthetic diamond sensors. Novel procedures in crystal manufacturing & testing and cutting-edge mechanical solutions for motion technology in vacuum are developed;- a silica screen that measures the deflected particles via Cherenkov radiation  emission in micrometric optical waveguides. These are obtained with an ultra-short laser micro-machining technique as for photonic devices used in quantum optics and quantum computing. The screen is a direct beam-imaging detector for a high radiation dose environment;- a smart absorber, which simulates the Earth’s atmosphere, where particles are smashed and secondary showers are initiated. This sets the path to measure hadronic cross sections at an energy relevant for cosmic rays investigation.The R&D for the various components of such a system are carried out within this project and direct tests at CERN Super Proton Synchrotron to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modelling, characterization and development of MgB2 superconductors for AC power applications', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

One of the high-temperature super-conductor (HTS) with greatest potential for large-scale industrial applications is the recently discovered (in 2001) Magnesium Diboride (MgB2). The introduction of novel MgB2-based electrical devices in the existing and future European power networks will increase their efficiency, power quality and the optimisation of available resources. At this stage, however, further RTD efforts on MgB2 conductor development are required, especially towards power applications, for which the AC losses are of primary concern. The main goal of this project is the development of novel low-loss MgB2 wires and tapes with improved properties for AC power applications. For this purpose advanced 2D and 3D numerical methods will be used for conductor modelling in different operating conditions.The AC loss mechanisms will be investigated and possible ways for loss minimization will be studied by finite-element method simulations. The optimal geometries and conductor configurations (in terms of lowest AC losses) will be used for the design of novel conductors with improved AC loss performance, produced in long lengths. In addition, experimental characterization of the conductors will be performed, consisting of measurements of the critical current in magnetic field, as well as of the transport current and magnetization AC losses. This is a multidisciplinary project, involving crucial aspects of materials science, experimental physics, and electrical engineering. The transfer of knowledge and skills in numerical modelling, and the acquired advanced experimental know-how, will allow the host organization to consolidate its international collaboration and reinforce its position as a leading European manufacturer of long-length MgB2 conductors for large scale appli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Redox Regulation of Nuclear Proteins'.

assistant: **Objectives**

Abiotic stress has a major impact on plant growth and performance, crop yields being significantly decreased as a result of the cessation of growth under conditions of mild stress. Growth arrest arises from a cessation of cell division in meristems. The cell cycle stops in G1 phase in response to changes in the glutathione [GSH] pool, which is itself a measure of abiotic stress. Poly(ADP)ribose polymerase (PARP) provides a further link between abiotic stress and the cell cycle, as down-regulation of this enzyme enhances plant stress tolerance. The present project links cell cycle regulation and stress biology, building on existing expertise in redox metabolism and growth regulation at the host laboratory. This project will exploit the essential know-how in cellular redox metabolism, cell cycle regulation, proteomics and microarrays to elucidate and characterise the components that regulate the recruitment of GSH into the nucleus and influence cell cycle progression and abiotic stress tolerance, through the regulation of nuclear proteins such as PARP. The overall aim is to understand the redox regulation of nuclear proteins by GSH and specifically how the nuclear and cytoplasmic GSH pools modify nuclear gene expression and nuclear protein function/activity during the cell cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Isaac Newton Institute for Mathematical Sciences Marie Curie Conferences and Training Courses, Framework 6 Series One' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The Isaac Newton Institute for Mathematical Sciences is an international research institute of outstanding reputation, covering the broad spectrum of mathematical sciences. During the period 2004 to 2008 the Institue will hold a number of interdisciplinary programmes and it is intended that Marie Curie Conferences and Training Courses will take place during these programmes. Those programmes approved to date for that period are Statistical Mechanics of Molecular and Cellular Biological Systems, Random Matri x Approches in Number Theory, Magnetic Reconnection Theory, Quantrum Information Science, Magnetohydrodynamics of Stellar Interiors, Model Theory and Applications to Algebra and Analysis and Pattern Formation in Large Domains. These programmes and others l ikely to be approved in the future cover a large part of the science and technology areas which form the seven thematic priorities of FP6. Mathematics is a vital underpinning tool across all sciences of immense importance, and conferences held at the Newt on Institute will encourage the development both of basic science and of new mathematical techniques relevant to established scientific areas. A common theme of all these Newton Institute programmes will be the ways in which mathematics is an essential com ponent of scientific advances, in particular in priority areas for the EC. The objective is to ensure that the work of the Institute, focussed in a theme at the conferences, is disseminated more widely in the European Community, and that more young people from across that community are given the opportunity to participate in workshops and seminars in a wide range of mathematically-related sciences. The Marie Curie Conferences and Training Courses are linked by the fact that they all explore an important to pic a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New Models of Sanctity in Italy (1960s-2010s). A Semiotic Analysis of Norms, Causes of Saints, Hagiography, and Narratives' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In cultures with a strong Catholic tradition saints represent models of life perfection, dialectically elaborated by a plurality of subjects and expressed in a thick intertextual network. Since the Second Vatican Council (1962-1965), when the Church promoted a policy of adaptation of her tradition to the modern world, the modeling of sanctity has undergone a deep transformation. In a context of global change, new models of sanctity have assumed a central role in guiding the faithful by proposing a renewed religious alternative to growing secularization.NeMoSanctI intends to study how models of sanctity have changed after the Second Vatican Council and their relationship with the culture of a country exemplum of strong Catholicism: Italy. To this end, it will apply a pioneering semiotic method based on the study of values, which will allow the comparative analysis of a corpus of texts of different genres:- normative texts regulating sanctity emanating from the Church;- judicial texts, i.e. causes of canonization of three famous Italian saints (Padre Pio, Gianna Beretta Molla, and Gerardo Maiella), with a focus on the dialectics between the models proposed by laic witnesses and by ecclesiastic inquirers;- narrative texts, i.e. a sample of popular hagiography about the three saints, of official hagiographic collections, and of Italian literary texts, where the theme of sanctity tends to be unconventionally elaborated and dissociated from Catholic values.Despite its relevance for a deeper understanding of the role of religion in today’s culture, a systematic research on new models of sanctity and on their intertextual codification is still missing. By carrying out this research and by proposing an innovative semiotic method for the analysis of models of life perfection, NeM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ubiquitous iNteroperable Care for Ageing People' (UNCAP).

assistant: **Concept**

The lack of ICT platforms based on open standards is regarded as one of the most significant market barriers to the creation of new care & assistance paradigms with global interconnection and interworking. UNCAP delivers an interoperable platform based on open industrial standards that leverages on existing technologies for biosensing, indoor/outdoor localisation and home-automation. The result is an open source, scalable and privacy-savvy ecosystem compatible with existing Personal Health Record systems, that can deliver novel services that can help aging people (incl. those with cognitive impairments) live independently and with dignity. To do so, UNCAP uses state-of-art physical/cognitive assessment tools together with technologies to locate objects, devices and users within indoor/outdoor spaces, to continuously monitor–in a non-invasive way- users and to assist them in case alert conditions are detected. In practice, UNCAP develops a product suite for formal and informal care environments made of: 1) the UNCAP BOX (an Android consumer device connected to TVs); 2) the UNCAP App for both users and caregivers; 3) the UNCAP CLOUD, delivering scalable care services; 4) the UNCAP certification suite, to help software and hardware manufacturers assess compliancy with standards.UNCAP will be assessed for 12 months in 14 pilots within real operational scenarios. Pilots will be located in rehabilitation centres, daily nursing facilities etc. and will involve 750+ users and 220 caregivers. Users’ physical & cognitive assessment will be carried on before and after the introduction of UNCAP to extract quantifiable metrics to assess its impact in terms of quality of care services and improved quality of life of users and caregivers.Lastly, UNCA will carry on a RoI analysis (both
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The impact of Regulation (EC) No 1394/2007 on the development of Advanced Therapy Medicinal Products (ATMPs): an academic perspective' (ATMPs).

assistant: **Innovation**

Advanced Therapy Medicinal Products (ATMPs) are medicinal products for human use, based on gene therapy, somatic cell therapy or tissue engineering. A rapidly growing area in translational research, they represent the ‘next generation’ of complex medicines for complex diseases and pose particular challenges to medicines regulation.Regulation (EC) No 1394/2007 has been designed to ensure the free movement of ATMPs within the European Union (EU), to facilitate their access to the EU market and to foster the competitiveness of European pharmaceutical companies while guaranteeing the highest level of health protection for patients. The regulation extends standards of current Good Manufacturing Practice (cGMP) to ATMPs to ensure their quality, safety and efficacy.Academic cGMP facilities are major contributors to the development of ATMPs. They respond to clinical needs and provide medicinal products in an environment which, albeit compliant with industrial standards, is by definition not industrial. They find themselves in a challenging position between various, sometimes conflicting interests in the transition of ATMPs from bench to bedside. European investigator-initiated multicenter trials on ATMPs critically depend on academic cGMP facilities.We will assess the impact of Regulation (EC) No 1394/2007 on academic cGMP facilities by:  a) conducting a European survey among non-industry facilities in this sector; b) organising workshops and a major conference for targeted, collaborative discourse; c) establishing a web-based platform for information exchange; d) analysing publications and guidance from the perspective of better regulation principles; e) analysing innovation statistics in relation to ATMPs.These activities will yield comprehensive evidence and concrete suggest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Passive retrofitting of office buildings to improve their energy performance and indoor working conditions' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives The program aims to develop retrofitting strategies, tools and design guidelines in order to promote successful, cost effective implementation of passive solar and energy efficiency measures to offices. These are addressed through the following objectives: 1) To combine scientific and technical knowledge with best practice architecture and energy engineering to prepare global retrofitting strategies for office buildings involving the use of passive solar and energy efficiency technologies. 2) To develop performance criteria, tools and rating methodologies to help designers integrate recent research results on passive and energy efficiency technologies. 3) To contribute through monitoring actions towards a better knowledge of the specific energy consumption characteristics and a more complete understanding of the qualitative problems of the offices in Europe. 4) To integrate all the results into a design and assessment methodology for retrofitting office buildings in Europe. Technical Approach The project is based on specific monitoring actions in order to collect the necessary data to evaluate the existing situation in office buildings. Based on various criteria, ten office buildings will be selected for which detailed architectural and engineering retrofitting studies will be prepared and quantified. The collected data as well as the overall analysis will permit the development of design guidelines, performance criteria and methodologies for best practice giving credit for renewable energy sources incorporated into office buildings presented in the form of a Handbook. The specific analysis of the results will permit the development of a rating methodology for office buildings based on the energy performance of the building, the environmental impact and CO2 p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Gabab receptors in health and disease' to be submitted under Fourth Framework.

assistant: **Abstract**

Cellular and sub-cellular localization of GABAB receptor subtype(s) in the cortex, thalamus and spinal cord.Physiological function(s) of GABAB receptor subtype(s) investigated by biochemical, ion imaging, and in vitro and in vivo electrophysiological techniques in the cortex, thalamus and spinal cord. Genetic, morphological, biochemical and electrophysiological analysis of GABAB receptor subtype(s) in experimental models of absence epilepsy and chronic pain. In order to determine the physiological functions of GABAB receptor subtype(s) and their role in epilepsy and chronic pain the following experiments will be carried out in control animals and in experimental models of these diseases. Linkage analysis of aberrant genes and homology screening for GABAB receptors will be performed in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS).  Using selective antibodies, the cellular and subcellular localisation of GABAB receptors in the brain will be investigated in developing (P1 - P40) and adult Wistar rats, in GAERS and in two models of chronic pain (Freund's adjuvant monoarthritis and carrageenan-induced inflammation). Autoradiographic and binding techniques will be used to detect the presence of GABAB receptor subtype(s) with different interactions with GTP-binding sites in Wistar and GAERS rats. The brain areas involved in convulsive seizures following injection of GABAB receptor antagonists will be localized by means of c-Fos induction and metabolic rate of glucose, while amino acid levels will be monitored in vivo using microdialysis probes.  The mechanism underlying modulation of transmitter release by GABAB receptors will be studied by combined in vitro electrophysiology and Ca2+ imaging. In vitro and in vivo electrophysiological techniques should allow to as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Defining strategic financial governance of innovation: institutional context(s) and strategic capabilities of State-Investment Banks in the EU.' (DeFInE).

assistant: **Innovation**

Development Finance Institutions in Europe (DeFInE) is a multidisciplinary research project that aims at developing an institutional conceptual framework for development finance institutions or state-investment banks (SIBs) in the European Union and analyzing their strategic competences that are directly linked to their policy roles. SIBs are increasingly recognized as strategic agents of change in providing scarce long-term resources to risky projects that commercial financial sector is either unable or unwilling to finance. Following an emerging discussion over ‘Entrepreneurial State’ and the need to make financing an integral part of innovation policies, SIBs should be considered as an active element of financial governance of innovation and development. Despite a large number of currently existing SIBs, their analysis has been mostly focused on policy objectives, financial instruments and corporate governance. However, not all SIBs have been successful in playing strategic policy roles. Reasons are complex: lack of strategic industrial policies, or changes in policy objectives, political interference, changes in sources of funds and corporate strategies, but also, and more importantly, lack or change of internal strategic competences. The project combines evolutionary economics perspective (dynamic capabilities), economics of innovation (financing of innovation) and public governance perspective (policy capacity, bureaucracy) in order to analyse institutional contexts and internal capacities of SIBs. In doing so, the aim of the project is to better understand what makes some SIBs strategic state-backed investors in financing innovation-led growth while others – less so. The context of multinational governance of the EU adds another unique dimension to the study. Eur