RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of molecular chaperones encoded by f1 operon of Y. Pestis for the design of E. Coli strains secreting heterologous proteins for medical and veterinary use' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Foreseen ResultsThis work will provide further insight into the mechanism of chaperone-mediated protein secretion in bacteria, particularly with reference to the Caf1M-like subfamily of chaperones, as follows:- X-ray data of Caf1M protein- theoretical model of the Caf1M-Caf1 complex- importance of the disulphide bond and accessory sequence" to the specificity and chaperoning function of Caf1M- localisation of active sites/interaction sites on the periplasmic chaperone and F1 subunit- optimisation of bacterial strains producing recombinant cytokines GM-CSF, IL-1b. IL-1ra- information on protective properties of components of the f1 operon.It will also provide new data on molecular chaperones as a part of an intracellular innate immune system.Knowledge about molecular chaperones, which act as an intracellular innate immune system common to all organisms provides the basis of the present project. Molecular chaperones describe a class of conservative proteins which ensure that the folding of certain other polypeptide chains and their assembly into oligomeric structures occur correctly. Chaperones have an ability to recognise and stabilise partially folded structures. Some may recognise incorrectly assembled or misfolded proteins resulting in disaggregation and a chance to refold or to facilitate degradation. In addition to the folding processes, some chaperones play an important role in polypeptide translocation across biological membranes, both into different organelles (e.g. mitochondria, endoplasmic reticulum/golgi) and into the extracellular medium. A family of periplasmic chaperones are involved in biogenesis of virulence associated surface structures in Gram negative bacteria. These chaperones specifically recognise and bind to subunits of surface structures (pili, fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Art Historiographies in Central and Eastern Europe An Inquiry from the Perspective of Entangled Histories' in the context of a Horizon 2020 call.

assistant: **Objectives**

Our project proposes a fragmentary account of the art histories produced in present-day Poland, Hungary, Slovakia, Romania, Bulgaria and Serbia between 1850 and 1950, from an entangled histories perspective. We will look at the relationships between the art histories produced in these countries and the art histories produced in Western Europe. But, more importantly, we will investigate how the art histories written in the countries mentioned above resonate with each other, either proposing conflicting interpretations of the past, or ignoring uncomfortable competing discourses. We will investigate the art histories written between 1850 and 1950 because we are interested in how art history contributed to nation building discourses. Therefore, we will focus on those art histories that concur to nationalising the past. Our project is articulated around three crucial concepts – periodisation, style and influence – set in the context of relevant contemporary historiographies produced in Western Europe, and analysing the entanglements with competing historiographies in each of the countries considered. We will focus on two main issues: 1. How did Central and Eastern European art historians adopt, adapt and respond to theoretical and methodological issues developed elsewhere, and 2. What are the periodisations of art produced on the territory of Central and Eastern European countries; what are the theoretical and methodological strategies for conceptualising local styles; and how was the concept of influence used in establishing hierarchical relationships. Researching the conceptualisation of a theoretical framework that would accommodate the artistic production of the past will show the difficulties in dealing with a complex reality without simplifying and essentializing it al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'COllaborative Network for Training and EXpertise in psychoTraumatology'.

assistant: **Objectives**

Mental health disorders afflict more than one-third of the EU’s population each year with an annual economic cost to the EU of €432 billion. The ‘COllaborative Network for Training and EXcellence in psychoTraumatology’ (CONTEXT) is an international, interdisciplinary European Industrial Doctorate (EID) designed to address deficiencies in psychotraumatology training and innovation. A key feature of CONTEXT is the minimum 50% secondment of each ESR to the non-academic sector. Consistent with the requirements of an EID, this component grants ESRs access to populations not otherwise accessible in standard doctoral training programmes. This design will facilitate a new cohort of researchers and practitioners who can translate research into practice, thereby mitigating the impact of psychotrauma in the EU. The goal of CONTEXT is to develop a high quality, innovative research training programme to build capacity and expertise, and foster innovative practice and social enterprise in the area of psychotraumatology. The nine beneficiaries of CONTEXT represent a diverse, interconnected, intersectoral consortium, well placed to collaboratively train and supervise the 12 ESRs. Three interconnected research work packages, each targeting a priority population in Europe (EU-based asylum seekers and refugees, WP3; emergency-service personnel and humanitarian first-responders, WP4; and victims and perpetrators of childhood- and gender-based violence, WP5), address current and emergent skill and professional deficiencies that are essential in curbing the adverse social consequences of trauma-related psychological distress within the EU. CONTEXT enjoys significant support and commitment from highly regarded, international stakeholders and influencers at the political, scientific, and profe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Dust Devils in Galaxy Centres' (DUSTDEVILS) under Horizon 2020.

assistant: **Objectives**

Active galactic nuclei (AGN) are the most powerful objects in the Universe. Their power source is accretion of surrounding matter onto the supermassive black holes in the galaxy centers. During the accretion process huge radiation pressure builds up preventing a large amount of matter to actually fall into the black hole. Instead, it is blown away in polar directions up to kiloparsec scales. Recently, it was discovered that these polar winds are very dusty and form hollow cones and therefore roughly resemble dust devils. This research action aims at investigating this newly discovered dust structures because they have the potential to significantly advance our understanding not only of the AGN phenomenon but contribute to the question of how the feedback on AGN onto their host galaxies works. Specifically, the polar dusty winds could  dominate the power output of the AGN in the mid-infrared (MIR) which so far has been firmly attributed to the canonical torus structure. Here, I propose to study the polar dust structures in AGN with unprecedented new observations. First, I want to asses the ubiquity of these structures, and second determine their physical properties including dust composition. The results will be used test whether they are caused by dusty polar wind being launched from the accretion disk and driven by the radiation pressure to large distances. If true, our picture of the nuclear dust structure of the AGN could be transformed  from a static phenomenological torus into a highly dynamic structure where the obscuration is caused by the combination of the accretion disk and the base of this dusty wind. This would be a result of high impact in the field and together with the training objectives of this fellowship allow me to reach and demonstrate professional m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Global Re-ordering: Evolution through European Networks' under Seventh Framework.

assistant: **Concept**

GREEN will study the current and future role of the EU in an emerging multi-polar world through a programme of stock-taking, multi-disciplinary research and complementary activities. It aims at an understanding of the prospective directions of the emerging global governance structures and Europe’s place in them.Analysis will focus on the extant actors from the 20th century, the 21st century rising powers, the increasingly influential non-state actors (from civil and non-civil society) and the new transnational regulatory networks of public and private policy makers and regional agencies. While multi-polarity, with Europe as a pole, is a possibility, alternative scenarios are also plausible. A shift from a trans-Atlantic to trans-Pacific locus of power, or the “depolarization” and fragmentation of authority are such alternatives; both could marginalize Europe.  But these are questions to be researched; not assertions to be made.The project will have 5 components: i) conceptual analyses of an emerging multi-polar world and the theory and practice of international organisation and networks in that world; ii) evolving EU policy and practice; iii) the effects of regional leadership from Africa, Asia-Pacific and the Americas; iv) projects on the EU and multi-polarity within the fields of human rights and security, energy, resources and environment, trade and finance; v) a foresight study detailing scenarios for EU policy towards the emerging world order. The research will be theoretical, policy-oriented and with an interactive dissemination strategy to assure feedback from its target-publics.The work will be undertaken by a manageable consortium of partners (from Belgium, UK, Netherlands, Denmark, Hungary, Spain, Italy and Norway with a strong track-record of collaboration on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'RESILIENT2: A novel thermosensory module at the interface of temperature and defense signaling' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The proposed project aims to define the molecular framework at the interface of  plant immunity and temperature signaling pathways.  To sense and respond to external environmental cues is critical for adaptation of plants to local environments. Temperature is a key seasonal variable controlling plant processes like developmental decisions as well as outcomes of plant-pathogen interactions. Elevated temperatures cause reduced resistance to pathogens resulting in enhanced susceptibility. Climate change, most importantly increasing global temperatures, poses a severe threat to agriculture and biodiversity. Though known for long, the phenomenon of temperature induced disease susceptibility is not sufficiently well understood at the molecular level. A unique Arabidopsis mutant resilient2 (res2) with temperature resilient defense response has been identified through a novel forward genetic screen. The res2 mutant also displays defective temperature sensing phenotypes suggesting that RES2 encodes a novel thermosensory molecule that modulate plant defense. I will systematically characterize the res2 mutant to define the molecular mechanism by which RES2 regulates temperature sensing and plant immunity. Findings of this study will answer the longstanding fundamental biology question of how environmental signals are integrated, especially the molecular basis for temperature induced defense breakdown. This will contribute to developing climate resilient crops in the wake of unprecedented increase in temperature as a result of global climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High performance OLEDs using deep red (DR) and near-infrared (NIR) TADF emitters' in the context of a Horizon 2020 call.

assistant: **Objectives**

First-generation fluorescent and second-generation phosphorescent organic light-emitting diodes (OLEDs) can achieve maximum internal quantum efficiency (IQE) of 25% and 100%, respectively. Phosphorescent OLEDs with complexes based on iridium and platinum realize 100% IQE due to the heavy atom effect. However, there are limitations, including but not limited to their scarcity and toxicity profile. The third generation OLEDs based on a thermally activated delayed fluorescence (TADF) process can be realized in purely organic materials and produce devices with 100% IQE. So far, there are examples of high-performance blue, green and red TADF OLEDs; however, limited attention has been paid to deep red (DR) and near-infrared (NIR) TADF emitters (650-750 nm). Such DR and NIR emitters find applications in night vision displays, sensors and information-secured displays etc. Current NIR OLEDs are associated with issues related to efficiency roll-off, lifetime and purity of emission color. Most importantly, the materials contain osmium, iridium, or platinum metals and therefore these OLEDs suffer from the same issues as visible light phosphorescent counterparts. This proposal seeks to address the above issues by rational design of purely organic novel DR and NIR TADF emitters. Our design comprises of yet unexplored rigid anthrone-based strong electron acceptor decorated with suitably substituted donor carbazoles. Emission color tunability can be achieved as a function of donor choice and position and varying the strengths of either the donor or acceptor. The rigidity of the molecular components, the strengths of the acceptor/donor, the twisted conformation, and the presence of tertiary butyl groups on the carbazoles altogether will work coherently to furnish good device stability,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Peripheralized to Cell- and Organelle-Targeted Medicine: The 3rd Generation of Cannabinoid-1 Receptor Antagonists for the Treatment of Chronic Kidney Disease' under Horizon 2020.

assistant: **Concept**

Clinical experience with globally-acting cannabinoid-1 receptor (CB1R) antagonists revealed the benefits of blocking CB1Rs for the treatment of obesity and diabetes. However, their use is hampered by increased CNS-mediated side effects. Recently, I have demonstrated that peripherally-restricted CB1R antagonists have the potential to treat the metabolic syndrome without eliciting these adverse effects. While these results are promising and are currently being developed into the clinic, our ability to rationally design CB1R blockers that would target a diseased organ is limited. The current proposal aims to develop and test cell- and organelle-specific CB1R antagonists. To establish this paradigm, I will focus our interest on the kidney, since chronic kidney disease (CKD) is the leading cause of increased morbidity and mortality of patients with diabetes. Our first goal will be to characterize the obligatory role of the renal proximal tubular CB1R in the pathogenesis of diabetic renal complications. Next, we will attempt to link renal proximal CB1R with diabetic mitochondrial dysfunction. Finally, we will develop proximal tubular (cell-specific) and mitochondrial (organelle-specific) CB1R blockers and test their effectiveness in treating CKD. To that end, we will encapsulate CB1R blockers into biocompatible polymeric nanoparticles that will serve as targeted drug delivery systems, via their conjugation to targeting ligands. The implications of this work are far reaching as they will (i) point to renal proximal tubule CB1R as a novel target for CKD; (ii) identify mitochondrial CB1R as a new player in the regulation of proximal tubular cell function, and (iii) eventually become the drug-of-choice in treating diabetic CKD and its comorbidities. Moreover, this work will lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GATBIO NEXT: advancing GRT's 1st oral biologic - GB-AF-004 - to clinical demonstration and out-licensing' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

GAT Biosciences (GATBIO) is a women-led Biotech SME targeting the exploitation of its proprietary GRTTM technology as a novel solution for the development and production of complex biologic drugs for biopharma and veterinary markets. Specifically, we are developing a game-changer next generation of accessible and non-invasive (oral, topic, inhaled)  biopharmaceuticals through proprietary and sustainable microalgae biofactories.Our first candidate for the biopharmaceutical Market, GB-AF-004, will enter pre-clinical demonstration in 2023.  GB-AF-004 is an anti-inflammatory biologic for the oral treatment of Inflammatory Bowel Diseases and Disorders (IBDs). The term IBDs includes a range of chronic and painful autoimmune diseases affecting localy the intestine, affecting patients from their youth and throughout life and of unknown causess. More than 6 million people are affected by IBDs globally and their global treatment market is estimated by 2029 at 37 billion euros per year. GB-AF-004 has the potential to be a game-changer in the treatment of this high prevalence and chronic inflammatory intestinal diseases.GATBIO has been recently granted a Seal of Excellence from the EIC accelerator Program supporting disruptive European SMEs for their acceleration to the market. The related funding will allow us to enter the preclinical development of GB-AF-004 early in 2023. In this frame, additional support related not to scientific development per se but to reinforcing our strategic business management and vision could be key to success in our next steps and culminate GB-AF-004 out-licensing. Specifically, to access Expert mentoring and Biomed advice related to i) clinical positioning in the IBD market and ii) out-licensing strategy, would be key to success in the arrival of our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Active Magnetorheological Elastomers: from Hierarchical Composite Materials to tailored Instabilities' under Horizon 2020.

assistant: **Concept**

In recent years, there has been an increased effort by scientists to obtain new composite materials with extreme properties. Inspired by natural and biological processes, scientists have proposed the use of hierarchical architectures (i.e., assembly of structural components) spanning several length scales from nanometer to centimeter sizes. Depending each time on the desired properties of the composite material, optimization with respect to its stiffness, weight, density, toughness and other properties is carried out. In the present subject, the interest is in magneto-mechanical coupling and tailored instabilities. Hierarchical materials, such as magnetorheological elastomers (MREs) which combine magnetic particles (at the scale of nanometers and micrometers) embedded in a soft polymeric non-magnetic matrix, give rise to a coupled magneto-mechanical response at the macroscopic (order of millimeters and centimeters) scale when they are subjected to combined magneto-mechanical external stimuli. These composite materials can deform at very large strains due to the presence of the soft polymeric matrix without fracturing. From an unconventional point of view, a remarkable property of these materials is that while they can become unstable by combined magneto-mechanical loading, their response is well controlled in the post-instability regime. This, in turn, allows us to try to operate these materials in this critically stable region, similar to most biological systems. These instabilities can lead to extreme responses such as wrinkles (for haptic applications), actively controlled stiffness (for cell-growth) and acoustic properties with only marginal changes in the externally applied magnetic fields. Unlike the current modeling of hierarchical composites, MREs require the de