RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'C4 photosynthesis transcriptomics' (C4TRAN) targeting Seventh Framework.

assistant: **Abstract**

C4 photosynthesis concentrates CO2 around RuBisCO and so increases the efficiency of photosynthesis. In the vast majority of C4 species the biochemistry of photosynthesis, and also the cell biology and development of leaves is altered. Despite these complex changes, the C4 pathway has evolved at least 45 times independently. Because C4 photosynthesis is more efficient in C4 plants, it has been proposed that engineering the C4 pathway into C3 crops such as rice would be beneficial for productivity. For this to be feasible, we need a better understanding of the basic mechanisms underlying C4 photosynthesis. I aim to investigate mechanisms generating cell specific gene expression in C4 plants, and will use C. gynandra, the most closely related C4 species to the C3 model Arabidopsis. I will generate comprehensive profiles of transcript abundance in mesophyll (M) and bundle sheath (BS) cells using laser capture microdissection and Illumina sequencing. I will also generate knock-down lines of C. gynandra for 20 transcription factors that we have identified as candidates for maintaining patterns of gene expression required for C4 photosynthesis. The project will significantly increase our understanding of basic mechanisms underlying C4 photosynthesis, and therefore may facilitate introduction of C4 traits in C3 crops.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'From Gene to Cure', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

GCure aims at unlocking the Research & Innovation (R&I) potential of the University of Coimbra (UC) in Biomolecular Medicine. The actions involves establishing an ERA Chair dedicated to next-generation Gene Therapy Vectors, building upon UC's strong foundation in Gene Therapy research at the Center for Neuroscience and Cell Biology (CNC-UC). Gene Therapy, utilizing genetic material to treat or prevent diseases at their root cause, promises a significant shift in medical treatment paradigms, particularly for inherited diseases. With 24 approved gene therapies and ongoing developments, the field shows promise, yet faces challenges, notably in viral vector-based delivery systems.The specific objectives of GCure include creating a core R&I cluster on next-generation Gene Therapy Vectors, optimizing UC's viral vector production facility, establishing a training program on Gene Therapy knowledge & technology transfer, expanding UC's participation in collaborative R&I projects, and enhancing UC's international recognition in the field. To achieve these goals, renowned gene therapy pioneer R. Jude Samulski has been appointed as the GCure ERA Chair holder. Samulski's expertise and achievements in the field, including multiple FDA-approved gene therapies and numerous patents, ensure leadership in advancing UC's Gene Therapy initiatives.GCure also aims to attract international researchers to UC, fostering a sustainable research group and enhancing resources. Synergies between diverse research subjects will improve UC's research and innovation performance, attracting high-value collaborations and funding opportunities. In-house reforms in research management and open science strategies, coupled with a robust training program, will maximize GCure's contribution to the knowledge-base
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Proteomic investigations of ubiquitin signals in DNA repair and chromatin organization' (PROTEUS).

assistant: **Innovation**

Genome integrity is constantly challenged by endogenous and environmental factors that can induce different types of DNA lesions. Failure to repair DNA lesions can lead to genomic instability and contribute to human diseases such as cancer and premature ageing. To counteract these potentially devastating effects caused by DNA damage, eukaryotic cells have evolved complex DNA repair pathways. Protein ubiquitylation has emerged as an important regulatory mechanism of the cellular response to DNA damage: Ubiquitin-modifying enzymes are recruited to sites of DNA damage and are essential for the repair of DNA lesions. However, for most of these enzymes the protein substrates that are modified in response to DNA damage and the molecular functions in DNA damage signalling remain obscure.Recent advances in mass spectrometry as well as novel methods for the enrichment of ubiquitylated peptides permit to systematically study protein ubiquitylation after cellular perturbations. In the proposed research project we plan to perform a quantitative analysis of protein ubiquitylation in ubiquitin ligase knockdown cells to identify the physiological substrates of ubiquitin ligases that function in DNA repair and chromatin organization. To this end, the cellular expression of selected ubiquitin ligases, including RAD18, BRCA1/BARD1, RNF20/40 and RING1A/RING1B/BMI1, will be downregulated by transient transfection of siRNA. Wildtype and knockdown cells will be treated with DNA damage-inducing agents and the ubiquitylation patterns in these cells will be comparatively analyzed using quantitative mass spectrometry. Biochemical and cell biological methods will be employed to characterize the physiological relevance of the site-specific protein ubiquitylation for the target proteins. These inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Crop Wild Relatives utilisation and conservation for sustainable agriculture' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Crop Wild Relatives (CWRs), i.e. the COUSINs of domesticated crops, represent a natural source of genetic variation. The COUSIN consortium recognizes the value of CWRs for agriculture, but also the challenges of their utilisation. Through the COUSIN Readiness Levels (CRLs) we will demonstrate a roadmap for the use of CWRs in breeding and farming. We will work with five flagship crops: wheat, barley, pea, lettuce and brassicas. With these exemplary crops, we demonstrate how current challenges of stakeholders from farm to fork can be overcome using CWRs in formalised and participatory breeding. The COUSIN consortium has unique CWR-related expertise, data and breeding material that allows us to cover the translational pathway from the identification of wild plants to a market-ready crop in a five-year project. For each flagship crop, we identify priority traits of CWRs, design selection toolboxes and apply them in current breeding programmes in order to fulfil current and emerging stakeholders demands. Effective characterisation protocols are designed and will guide conservation of the naturally occurring functional and genetic trait diversity across Europe. Characterisation will occur in- and ex-situ through high-throughput phenotyping, chemotyping and genotyping of priority traits incl. plant-associated microbiomes. Conservation measures cover in-situ reserves and ex-situ collections with the widest possible trait diversity. For easy access of priority trait information and corresponding CWR accessions, a user-friendly data portal will be developed. All collected data will be offered for integration into national and international repositories. Through on-farm pilots and actual breeding sites realised across the European pedoclimatic regions, the value of CWRs will be de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'PRocurEments of innoVativE, advaNced systems to support security in public Transport – Pre-Commercial Procurment' under Horizon 2020.

assistant: **Concept**

The global aim of PREVENT Pre-Commercial Procurement is to augment the security in public transport through innovative procurement of technology solutions. The proposed technologies will endow Public Transport Operators with solutions enhancing security situational awareness through: i) Timely automatic detection of potentially dangerous unattended items in Public Transport Infrastructure and in public areas in the vicinity; ii) Identification and tracking of perpetrators; and iii) Advanced crisis management system. The PREVENT PCP project builds on the outcomes of its predecessor PREVENT, and it continues the top-down approach that allowed consolidating commonly agreed scenarios, covering the critical security issues down to a detailed identification of the complete set of innovation needs, both at process and technology levels, to ease coordination across the full chain of stakeholders, from transport operators to security forces and public authorities. Therefore, the need for innovative solutions stems from a longer collaboration and is driven by commonly identified internal needs to improve the quality and efficiency of pre-empting terrorist attacks. The project will conduct a phased Pre-Commercial Procurement composed of: Phase 1: To finalise the tendering documents package already prepared under PREVENT CAS; Phase 2: To implement the call for tenders for research and development services; Phase 3: To conduct the competitive development of the prototypes following the PCP principles (design stage, integration & technical verification stage and validation in real environment stage); Phase 4: To consolidate the results of the evaluation of the developed prototypes, extract conclusions and recommendations from the validation process, and to define a clear strategy for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Voices from the Deep South: the rise of Pattu song cultures of South Asia' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

VOICES offers a new, large-scale perspective on the history of song-performing cultures of South India in premodern and colonial contexts. More than a song, pattu stands for a multitude of interrelated constellations of song traditions - a galaxy of regional song cultures. One region alone (Kerala) boasts nearly eighty song genres, many of epic proportions: from songs of heroes and place through verses to awake a deity or activate a curse, to songs of ecstatic praise.  Most are embedded in recurring ritual events, linked to matrilineal order and performers of subaltern roots. Some connect to minorities: Christians, Muslims, Jews. Pattu invokes practices of deploying skills stored in songs to cure diseases, restore prosperity, empower listeners, or otherwise affect reality. From the 13th c. CE on, the song genres influenced literary forms as trans-medial textuality and cultural technology to store knowledge and generate trust. This rich universe remains understudied. Building a digital archive, VOICES will explore ways in which the sonic ecumene of singing the local in shared imaginary of the South proved resilient over centuries and embraced two languages of prestige: Tamil and Sanskrit. We shall study ontologies of singing the body, the suffering and deliverance, the humane and divine, movement and restraint in this unique subaltern record. We aim at a new understanding of the processes of forging identities at the crossroad of the literary and folk by mapping genre distribution, narrative patterns, transmission modes and cultural economies while identifying key moments of historical change. Fusing ethnomusicology, media and literary studies, VOICES wants to show why tracking this evolution has the potential to reveal intriguing trajectories of the formation of premode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tissue engineered bone formation, substitution and regeneration: application of porous calcium phosphate scaffold materials and growth factors.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The demand for Bone Graft Materials (BGM) has been increasing steadily in recent years particularly in orthopedic, dental, maxillo-facial and neurosurgery where there is a need to replace missing bone and enhance bone formation. Currently, bone autograft is the golden standard. Due to limited amounts it can only be used in cases of small defects. The harvesting procedure poses substantial risks for long term pain and discomfort with a risk of infection and nerve lesion. Alternatives such as bone alllografts are associated with risks of transferring blood borne diseases, e.g. HIV and various kinds of hepatitis. There are also problems with donor matching, storage and high costs of manufacturing. In the light of these factors, the use of Synthetic Bone Graft Materials (SBGM) is very attractive. There is particular interest in developing engineered SBGM which can be used as scaffolds for seeding cells and transplanted back in the body. This can enhance fixation and integration of the implant by encouraging bone in-growth and provide a viable alternative for load-bearing and non load-bearing osseous defects such as joints and maxillo-facial reconstruction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Characterization and engineering of neural stem cells'.

assistant: **Innovation**

The objectives of this project are to characterize central nervous system (CNS) stem cells and to gain insights into how their differentiation to neurons can be controlled. Neurons and glial cells in the adult CNS are derived from CNS stem cells, which therefore are of considerable medical importance. First, aberrant behaviour of CNS stem cells is implicated in CNS tumors and CNS malformations. Second, CNS stem cells can be used in transplantation in neurodegenerative diseases, as a therapeutic approach. Third, new insights into neuronal differentiation of CNS stem cells may be important to improve treatment following injuries to the brain and spinal cord, in particular since it has recently been shown that also the adult CNS contains small populations of CNS stem cells. This brings the CNS stem cell at the focus from a medical perspective and in this proposal we will address a number of key issues of CNS stem cell biology. We will do this in a series of 4 tasks with the participation of 5 different research groups in 5 countries, one of whom is an industrial partner. In task 1, we will compare the molecular characteristics of embryonic and adult CNS stem cells from three different CNS regions. This will lead to a better understanding of the cellular complexity and a more reliable identification of CNS stem cells. In task 2, we will analyse the function of individual genes in the Notch/Hes/Mash/Ngn signaling pathway, which is one of the major signaling systems controlling CNS stem cell development. This will be accomplished by ectopically expressing or functionally inactivating the genes in transgenic mice, which will link specific genetic alterations to particular effects on CNS development in vivo. In task 3, we will establish strategies allowing us to control prolife
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Heating Appliances Retrofit Planning' (HARP) under Horizon 2020.

assistant: **Objectives**

Consumers do not think about heating until their system breaks down. When it does, the replacement is always an urgent process, hindering the possibility to look for the best solutions in the market and making smarter choices regarding a heating system that will likely be in operation for the next 20 years. In Europe, there are more than 300 million heaters (space, water or combi) that have, on average, been installed more than 20 years ago. Considering the heating energy label framework, market assumptions are that more than 50% of these equipments perform as C or lower. Old and inefficient, this is the status of the installed heating stock. Now is the time to act and raise consumers’ awareness about the opportunities of a planned replacement. Taking advantage of the energy label for space and water heating, we can mainstream the labelling concept to the installed heating stock, allowing to use a well-known support decision tool to communicate and motivate the consumer to replace its heating system with modern high-efficiency and renewable solutions.  HARP accompanies the consumer decision process, providing an impartial message, based on the energy label and presenting the market solutions that respond to the consumer’s heating needs, providing a quantified approach for economic and non-economic benefits and bridging the gap with the market providers and available national incentives. HARP is promoted by key knowledgeable partners in the fields of consumer behaviour, energy efficiency, heating solutions and business models, working directly with the consumer, or indirectly via professionals who are critical multiplying agents. Promoting dynamic efficient heating communities, where all the agents, from the supply to the demand side are committed to an efficient heating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Design-Operation Continuum Methods for Testing and Deployment under Unforeseen Conditions for Cyber-Physical Systems of Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The ADEPTNESS project seeks to implement and investigate a streamlined and automatic workflow that makes methods and tools to be seamlessly used during design phases as well as in operation. We will explore the generation and reuse of test cases and oracles from initial phases of the development, to the system in operation and back to the laboratory for reproduction. Integrated in this workflow, unforeseen situations will also be detected in operation to enhance development models for increasing resilience. We will consider several aspects of uncertainties (such as uncertainties in environment, uncertainty produced due to timing aspects of CPSoS, uncertainty in networks, etc.). Additionally, automatic and synchronized deployment techniques will be investigated to improve the agility of the whole workflow that covers the design-operation continuum.


**Keywords:** Design-operation continuum,  Cyber-Physical Systems of Systems,  Software Engineering,  Testing,  Deployment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Evolution on the Nile: Faunal Regionalization and Continuity in the Pleistocene of Sudan'.

assistant: **Objectives**

Over a century of paleontological investigation in Africa has revealed a rich Pleistocene fossil record that includes the evolution of hominins and their material cultures. However, the vast majority of fossil sites are located in the East African Rift Valley (EARV), and our knowledge is heavily skewed by this geographic bias. Poor continental geographic sampling means we lack an understanding of faunal regional variations, and the role of dispersal and geographic variation in the emergence of modern ecosystems. Furthermore, many have questioned the role of the Nile, the longest river in the world, in promoting faunal and cultural dispersal between Subsaharan and North Africa, and beyond to Eurasia. For decades such questions have been answered speculatively, with little data to stand on. PALEONILE is an ambitious project that will address these major gaps in our knowledge through large-scale surveys to reveal a new fossil record from the Middle Nile River Basin in Sudan. This project will test an overarching hypothesis of Pleistocene zoogeographic regionalization in the Nile Basin with respect to the EARV and surrounding areas, and will use an interdisciplinary array of paleontological, geological, geochronological, and archaeological approaches to reach its objectives. The geographic scale of the project is large and the techniques are cutting edge, including high-risk experimental methodologies such as paleobiomolecular recovery and new developments in sedimentary dating. PALEONILE forms the first ever large-scale systematic paleontological project to be conducted in Sudan, where the Cenozoic fossil record remains largely undiscovered, and its potential overlooked. PALEONILE will generate a new paradigm of zoogeographic dynamics and evolution in the African Pleistoce