RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MicroILCs: Deciphering how the gut Microbiota influences Innate Lymphoid Cells in obesity""""' (MicroILCs).

assistant: **Innovation**

Obesity reaches epidemic proportions and currently represents a significant public health challenge. Curbing the prevalence of obesity is one health policy priority, whose achievement requires more effective preventive measures. A high-caloric diet and sedentary lifestyle are key determinants of obesity. The diet shapes gut microbiota composition, which may partly explain why microbiota alterations are associated with an obese phenotype in humans. These microbial alternations have been proven to contribute to energy metabolism and fat storage. This evidence has represented an unprecedented shift in the way we envision obesity management. However, translating this knowledge into microbiota modulation strategies that can be applied in the clinical setting needs a better understanding of the active players within the gut ecosystem, as well as, of the mechanisms underlying their dialog with the host. Preclinical studies show that the microbiota shapes immune responses beyond the intestine with consequences for metabolic health. This proposal aims to decipher the regulatory role of indigenous intestinal bacteria on the recently discovered innate lymphoid cells (ILCs). To achieve this goal, we will use the collection of intestinal human bacteria created in the context of the EUproject MyNewGut by the host institution, first, to identify those with ILCs stimulatory properties and second, to perform mechanistic studies in wild-type and mutant murine models of diet-induced obesity coupled to in vitro experiments with primary cell cultures. Overall, the objective of the MicroILCs proposal is to move forward in the understanding of the mechanisms whereby the gut microbiota controls the immune response to high-energy diets and affects the metabolic phenotype.


**Keywords:** gut mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Comprehensive two-dimensional liquid chromatography for the characterization of protein biopharmaceuticals at the protein level' (LCxLCProt).

assistant: **Innovation**

Protein biopharmaceuticals, which globally represent about 20 % of the total pharmaceutical market, are becoming increasingly popular in the treatment of various diseases. Experts forecast that over 50 % of new drug approvals in the next decade will be for biologics, especially monoclonal antibodies. Very accurate structural characterization and purity analysis is required during both the development of the new drugs, and later during manufacturing for quality control purposes. Biopharmaceutical protein molecules are very large and heterogeneous, which makes their characterization very difficult. The goal of this project is to develop novel methods for the characterization of protein biopharmaceuticals at the protein level based on comprehensive two-dimensional liquid chromatography (LC×LC). Two approaches will be explored: the use of reversed phase separation mechanism in both dimensions with parallel gradients, and application of thermally responsive stationary phases for thermal modulation of LC×LC fractions. Parallel gradients provide the greatest orthogonality when the separation mechanisms in both dimensions are correlated, and allow the use of short modulation periods, which together lead to a dramatic increase in peak capacity (as demonstrated in preliminary experiments). Thermally responsive stationary phases allow trapping of the analyte bands at elevated temperatures, and their release at low temperature. This is compatible with intact protein analysis, especially when ion exchange is used in the first dimension of the LC×LC system. It is expected that the research will result in new, cutting edge methods for the analysis and characterization of protein biopharmaceuticals that will be applicable under the good manufacturing practice (GMP) conditions, improvin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Recovery of organic solvents in edible oil extraction by nanofiltration (ROSE)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project aims at the development and industrial implementation of ceramic nanofilters in the edible oil refinery process for the recovery and recycling of organic solvent. In conventional oil processing, edible oils are usually extracted with an organic solvent, which is partly recovered by distillation. Thermally and chemically stable ceramic nanofilters offer an economical and environmentally friendly alternative for solvent recovery, due to diminished solvent losses and lower energy consumption. Earlier developed ceramic nanofilters, obtained by sol-gel technique, will be the starting point for this application. Development and characterisation of nanofilters with improved characteristics is within the scope of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The transcriptional response to oxidative stress' (TranscriptStress).

assistant: **Concept**

Environmental stress triggers a cellular response to promote adaptation and survival, typically through activation of stress genes. What is less appreciated is that various types of cellular stress at the same time induce widespread transcriptional repression at most other genes. Although such transcriptional reprogramming is common to various kinds of cellular stress, recent evidence suggests it is governed by different stress-specific mechanisms. A brief exposure to oxidative stress leads to a rapid and transient global repression of transcription. However, our current knowledge about the oxidative stress response is extremely limited. Based on our preliminary results, I hypothesise that the transcriptional response to oxidative stress involves both regulation of transcription elongation as well as termination and that these are connected to post-translational modifications of RNA polymerase II (RNAPII) itself. Here, I propose an ambitious approach to investigate the transcriptome-wide oxidative stress response in human cells and following physiologically induced oxidative stress in mice. To this end, we will use a combination of state-of-the art sequencing techniques coupled with time-resolved proteomics and a novel screening approach. Together, our work will provide important new knowledge about the transcriptional response to oxidative stress and the factors involved – in an area that is currently not well understood. Such knowledge is also crucial to understand the fundamental mechanisms allowing RNAPII to stop transcribing and restart again. Finally, we will investigate how factors involved in the transcriptional response influence transcription-associated genome instability and neuronal cell identity. This will be relevant for diseases in which oxidative stress
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DEEP - Extreme Scale Technologies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The DEEP-EST (“DEEP - Extreme Scale Technologies”) project will create a first incarnation of the Modular Supercomputer Architecture (MSA) and demonstrate its benefits. In the spirit of the DEEP and DEEP-ER projects, the MSA integrates compute modules with different performance characteristics into a single heterogeneous system. Each module is a parallel, clustered system of potentially large size. A federated network connects the module-specific interconnects. MSA brings substantial benefits for heterogeneous applications/workflows: each part can be run on an exactly matching system, improving time to solution and energy use. This is ideal for supercomputer centres running heterogeneous application mixes (higher throughput and energy efficiency). It also offers valuable flexibility to the compute providers, allowing the set of modules and their respective size to be tailored to actual usage.The DEEP-EST prototype will include three modules: general purpose Cluster Module and Extreme Scale Booster supporting the full range of HPC applications, and Data Analytics Module specifically designed for high-performance data analytics (HPDA) workloads. Proven programming models and APIs from HPC (combining MPI and OmpSs) and HPDA will be extended and combined with a significantly enhanced resource management and scheduling system to enable straightforward use of the new architecture and achieve highest system utilisation and performance. Scalability projections will be given up to the Exascale performance class. The DEEP-EST prototype will be defined in close co-design between applications, system software and system component architects. Its implementation will employ European integration, network and software technologies. Six ambitious and highly relevant European application
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'VISUALIZATION OF TOPOLGICAL STATES IN PRISTINE NANOWIRES' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Topological phases of matter have been at the center of intense scientific research. Over the past decade this has led to the discovery of dozens of topological materials with exotic boundary states. In three dimensional topological phases, scanning tunneling microscopy (STM) has been instrumental in unveiling the unusual properties of these surface states. This success, however, did not encompass lower dimensional topological systems. The main reason is surface contamination which is disruptive both for STM and for the fragile electronic states. We propose to study topological states of matter in pristine epitaxial nanowires by combining growth, fabrication and STM, all in a single modular ultra-high vacuum space. This platform will uniquely allow us to observe well anticipated topological phenomena in one dimension such as the Majorana end-modes in semiconducting nanowires. On a broader view, the nanowire configuration intertwines dimensionality and geometry with topology giving rise to novel topological systems with high tunability. A vivid instance is given by topological crystalline insulator nanowires in which the topological symmetry protection can be broken by a variety of perturbations. We will selectively tune the surface states band structure and study the local response of massless and massive surface Dirac electrons. Tunability provides a higher degree of control. We will utilize this to realize topological nanowire-based electronic and spintronic devices such as a Z2 pump and spin-based Mach-Zehnder interferometer for Dirac electrons. The low dimensionality of the nanowire alongside various singularities in the electronic spectra of different topological phases enhance interaction effects, serving as a cradle for novel correlated topological states. This n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The sources of legitimacy of the european union' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

This research project aspires to broaden the analysis of the so-called 'democratic deficit' of the European Union. For that aim it turns to the concept of political legjtimacy - as classically developed by Max Weber and recently taken up by Jürgen Habermas - and to recent contributions to the political theory of the European Union. Inspired by this work I propose two hypotheses that are to be elaborated:1 ) Apart from democratic institutions there are other sources of political legitimacy that may contribute to the public acceptance of political decisions, e.g. authority, legality and the substance of decisions;2) The European Union draws upon these sources of legitimacy in a way that is fundamentally different from the accustomed ways of the nation-states. The Union may require new mixes. It thus also challenges our existent conceptions of the sources of political legitimacy . The project is to yield one theoretical essay and five (or so) empirically grounded essays in which the framework is applied to thematically organized case-studies. Each of these thematic essays is organized around one of the sources of political legitimacy distinguished. For each source of legitimacy a particular set of case-material ( a particular policy dossier) is selected to demonstrate in what respects the conception of this source. as it is used in the context of the nation-state , needs to be revised in the EU-context. Eventually the essays are to be bundled in a book that is to provide an overall view of the various sources by which EU-decision-making is legitimized.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Explaining the winds of cool giant and supergiant stars with global 3D models' (EXWINGS).

assistant: **Concept**

Without stellar winds, life as we know it would not exist. Critical elements like carbon are produced inside luminous cool giant stars, transported to the surface by turbulent gas flows, and ejected into interstellar space by massive outflows of gas and dust. Direct evidence for this scenario comes in the form of dust grains produced in the stellar winds, and detected in meteorites by their isotopic composition. Nevertheless, the current understanding of stellar winds is far from sufficient to draw a realistic, quantitative picture of their effects on stellar evolution and their contribution to the enrichment of the interstellar medium with newly-produced elements and dust.Project EXWINGS aims at a breakthrough in understanding the winds of cool giant and supergiant stars with a novel modeling approach. We will produce global radiation-hydrodynamical ‘star-and-wind-in-a-box’ simulations, based on our recently-developed prototype. For the first time, it will be possible to follow the flow of matter, in full 3D geometry, all the way from the convective, pulsating interior of a cool giant, through its atmosphere and dust-formation zone, into the dust-driven wind region. Extending our unique approach to the warmer, more luminous red supergiants, we will explore alternative driving scenarios for their still enigmatic winds, involving magneto-hydrodynamic waves and radiation pressure on molecules and dust.The current progress in high-angular-resolution instruments, giving resolved views of the stellar atmospheres where the winds originate, presents an excellent opportunity for testing the new models. An ultimate goal is a predictive theory of mass loss and dust production in evolved stars, based on first physical principles. The results of EXWINGS will have a major impact on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multiplexed biosensing and tissue-on-a-chip integrated platform for breast cancer biomarkers monitoring' in the context of a Horizon 2020 call.

assistant: **Objectives**

In this project I will develop an integrated multi-module platform in which a breast cancer ecosystem-on-a-chip (BCE-on-a-chip) bioreactor module, connected to an optical biosensing module based on multiplexed Resonant Nanopillars (R-NPs) transducers, will be developed for biomarkers and anti-breast cancer drug real-time monitoring. Currently attrition rates in clinical trials for new anti-cancer drugs and personalized treatments are higher than all other therapeutic areas. Mainly due to the great reliability on conventional 2D and 3D scaffolds in-vitro culture methodologies in preclinical studies. Those cell-based models are limited by their  inability to conserve the patient tumor features and do not accurately show drug response, observed later in clinical trials.Due to the increasing number of cancer diagnoses, an engineered system that allows an accurate prediction of patient tumor response to anti-cancer drug, is urgently needed. In Bitform Project I will develop a BCE-on-a-chip bioreactor that intends to conserve the cancer tissue characteristics with high reliability. Breast cancer cell secreted biomarkers will be monitored in real-time with a multiplexed biosensing module based on R-NPs. In order to assess the capability of Bitform platform, an anti-cancer drug demonstrator (Paclitaxel) will be tested. By delivering Paclitaxel to the BCE-on-a-chip, monitoring of different cell secreted target biomarkers will permit to evaluate the effect of this drug, and thus to demonstrate the performance of the platform.The Bitform platform will be suitable for different organ-on-chip culture models and biomolecules monitoring secreted by the cells. This will lead to a new methodology for testing anti-cancer therapies on-a-chip. This is a relevant milestone to study the furt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Establishing in-depth services enhancing the innovation management capacity of South West of France SMEs in 2017-2018' to be submitted under Horizon 2020.

assistant: **Abstract**

The project involves 3 partners of the Enterprise Europe Network South West France consortium which covers the Aquitaine/Limousin/Poitou-Charentes region and the Midi-Pyrénées territory. The general objective is to contribute to raise the competitiveness of SMEs from this area by offering support services in the area of innovation management. The project will also contribute to develop more efficient and more effective innovation processes and higher quality innovation management capacity assessment and support services. The support will be delivered as service packages of 7 days to 2 groups of SMEs: a) Beneficiaries of the SME Instrument of Horizon 2020: to enhance the probability of a successful exploitation of the innovation project results and lead to the sustainable growth of the beneficiary beyond the participation in Horizon 2020. The support service will pinpoint weaknesses in the innovation capacities of the beneficiary, select suitable coaches to address the identified weaknesses and monitor the coach-client relationship and to accompany the beneficiary through the SME instrument project b) SMEs with significant innovation activities and a high potential for internationalisation: to enhance their innovation management capacities to be able to gain new international markets and leaderships. The support service will consist in an in-depth innovation assessment in order to develop and implement a tailored action plan to improve the SMEs capacity to manage innovation processes. The partners will use dedicated assessment tools: IMP3rove and Check’Innov. The project will last 24 months and will provide 84 support service packages.


**Keywords:** SME, Innovation management, SME instrument, SME support, funding, Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Wake vortex evolution in far-wake region & wake vortex encounter'.

assistant: **Innovation**

The potential safety problems associated with aircraft flying in the wake of other aircraft have long been recognized and strict separation rules, based on the weights of the following aircraft, have been devised. The increased air-traffic density near airports and the possible introduction of new very large aircraft like the A3XX, necessitate a reconsideration of the present rules. The present proposal adresses the wake vortex evolution and wake vortex encounter problem with a programme of experimental and computational research. The short term goal of the project is to create wake vortex encounter flight-simulation capabilitites that may assist in defining save aircraft separation rules for the A3XX project. The results from the present study will also contribute to establish future safely mitigated aircraft separation rules near airports.