RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Defective DNA Damage Responses in Dominant Neurodegenerative Diseases'.

assistant: **Concept**

DNA single-strand breaks (SSBs) are the most frequent DNA lesions arising in cells and are a major threat to cell survival and genome integrity, as indicated by the elevated genetic deletion, embryonic lethality, or neurological disease observed if single-strand break repair (SSBR) is attenuated. In particular, SSBR defects are associated with hereditary neurodegeneration in humans, as illustrated by the genetic diseases ataxia oculomotor apraxia-1 (AOA1), spinocerebellar ataxia with axonal neuropathy-1 (SCAN1), and microcephaly with early onset seizures (MCSZ). However, two major questions remain: what are the mechanisms by which SSBs trigger neurodegeneration, and to what extent do SSBs contribute to other genetic and/or sporadic neurodegenerative disease? Based on exciting new data we now propose that the impact of SSBs on neurodegeneration extends beyond rare SSBR-defective diseases to include more common motor neurone diseases (amyotrophic lateral sclerosis) and the genetically dominant spinocerebellar ataxias (SCAs). Ultimately, we suggest that SSBs might also be an etiological factor in normal human ageing. Finally, again based on new data, we propose that SSBs induce neurodegeneration by triggering over-activation of the SSB sensor protein, PARP1; thereby identifying inhibitors of this protein (currently licensed for cancer treatment) as a possible therapy for neurodegeneration. We will now address these hypotheses using a range of cutting edge molecular/cellular techniques. In particular we will (a), systematically examine all relevant amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) and spinocerebellar ataxia (SCA) proteins for involvement in the DNA damage response, (b) Identify the mechanism/s by which ALS and SCA proteins engage in the DNA dama
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SME process improvement in regions of Europe' (SPIRE), addressing dissemination and exploitation.

assistant: **Impact**

SPIRE's objectives are to lower the barriers preventing SSDs from successful participation in SPI by:raising awareness of SPI benefits among decision makers and change agents in SSDseducating participating SSD managers and staff in practical SPI skillshelping SSDs to maintain momentum in carrying through their improvement plansACTIONSSPIRE will generate, analyse and disseminate significant new case study and best practice material, in order to raise awareness of best practice and its benefits among small software developers (SSDs), and to promote their adoption of software process improvement. This will be achieved by using experienced mentors (paid by SPIRE) to guide SSDs through an assessment of needs, the preparation of a sound plan for a cost-effective, small SPI project (funded by SPIRE to a maximum of 15 KECU), implementation of the project, and evaluation of results. The experience gained ion the most successful projects will be published as short case studies aimed at decision makers in SSDs in 4 languages (German, Italian, English and Spanish). Data from all projects will be gathered in a standardised way, to permit analysis from which valuable lessons regarding best SPI practice for SSDs will be derived and published as a report. The results will be disseminated on paper, electronically and through workshops, both in the 4 participating regions of Ireland, Italy, Austria and Sweden, and throughout Europe. The partners are ARC Seibersdorf (Austria), ETNOTEAM (ITALY), IVF (Sweden), CSE (Republic of Ireland), and MARI and SIF (both in Northern Ireland). The project will be co-ordinated with other ESSI proactive dissemination projects DonQ-SPI and LSD, and will feed into the ESSI Best Practice Library, in particular the VASIE2 project.EXPECTED IMPACT AND EXPERIENC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a high sensitive and specific nanobiosensor based on surface enhanced vibrational spectroscopy dedicated to the in vitro proteins detection and disease diagnosis' (NANOANTENNA) targeting Seventh Framework.

assistant: **Abstract**

The main goal of our proposal is to develop a novel optical nanobiosensor based on extraordinary vibrational signal enhancement of the proteins to be detected. To reach vibrational signal enhancement, we will exploit the optical properties of specially designed metallic nanoparticles which should act as nanoantenna and the associated field enhancement to obtain a direct detection of proteins bound to the nanoparticle. Thus, our sensor will reach high sensitivity provided by the recently established large enhancement of vibration signals due to the resonant excitation of the nanoantenna device used as substrates. The aim is to detect only a few proteins with concentration much lower than 1pM and finally to reach detection threshold such as femtomole or lower. High molecular selectivity will be reached with the functionalisation of the nanoantenna. Such functionalisation will selectively favour the immobilisation of the protein to be detected at the vicinity of the nanoparticle surface, providing the best enhancement and then the detection of the targeted protein. Our nanobiosensor will include two main components: the nanoantenna device which corresponds to our sensor transducer and the functionalisation which corresponds to its bioreceptor. And then, each functionalised nanoantenna device used as vibrational signal enhanced system is an individual and specific nanosensor of proteins. As a consequence, our nanobiosensor integrated in a vibrational spectroscope will allow the detection and the analysis of the enhanced vibrational signal from the targeted proteins and thus corresponds to our diagnosis instrument. Our nanobiosensor will be validated on the detection of proteins on body fluids.These proteins have been chosen since they have been identified as specific biomar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Remote and Offline Ultrasound Image Analysis Platform' (2014-2020).

assistant: **Concept**

Ultrasound is a dynamic real time technology and very much operator dependent. Every week around 10 million medical ultrasound exams are performed globally. Around 90% of ultrasound procedures are done by an operator who captures the “image freeze” picture of the site of interest and delivers the scans to the physician in charge who “off-line” analyses the scans and elaborates the diagnosis. This workflow conceals the Pandora’s box of inefficiencies and, even worse, misdiagnoses in ultrasound imaging: the radiologist is only a viewer and the static images or video clip of the case available do not allow him to see what he really wants to see, preventing losing crucial data only available in real time during the patient’s scan. This leads to patients’ recalls, adoption of more expensive imaging techniques or, in the worse cases, misdiagnoses. iNNOGING's mission is to revolutionise the medical ultrasound workflow by providing a novel solution to enable every radiologist to remotely see and analyse offline ultrasound scans as if he was next to the patient, transforming the video clip taken by commercial ultrasound probes into a 3D representation of the scanned area that can be manipulated, analyzed and evaluated – just like an actual ultrasound examination. The system is made of proprietary probe and pad, which coupled with our image processing algorithms provide radiologists with a seamless data of the actual ultrasound exam. In an industry currently worth around 6B€ globally and traditionally focussed on a slow innovation pace, we see an enormous market creating potential for a workflow innovation providing benefits to radiologists, patients and National Healthcare Services. To capture this opportunity, we plan to sell the Innoging solution to hospitals and clinics throu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Structural sudies of the bacterial lipid rafts.'.

assistant: **Concept**

One of the most sophisticated concepts in membrane organization is the proposed existence of lipid rafts. Membranes of eukaryotic cells organize signal transduction proteins into microdomains or rafts, that are enriched in particular lipids like cholesterol. Lipid rafts are important for the correct functionality of numerous cellular functions, and their disruption causes serious defects in several signal transduction processes. The assembly of lipid rafts in eukaryotes has been considered a fundamental step during the evolution of cellular complexity, suggesting that prokaryotes were too simple organisms to require such a sophisticated organization of their membranes. Dr Lopez discovered that bacteria organize many membrane-related cellular processes in Functional Membrane Microdomains (FMMs) constituted by specific lipids, similar to the lipid rafts that are found in eukaryotic cells. Importantly, the perturbation of FMMs inevitably leads to a potent and simultaneous impairment of all harbored signal transduction pathways, which causes a potent inhibition of the infective potential in pathogenic bacteria. One such pathogen is Staphylococcus aureus that also organizes its membranes into rafts. Pbp2a, a protein responsible for the ‘methicillin-resistance (MRSA) phenotype’, interacts with one of the main component of the rafts, flotillin. We propose to perform a comprehensive structural study of the lipid rafts from S. aureus, starting from the global view of the rafts in situ, through analysis of the rafts assembled in vitro and finally to investigate a 3D structure of the flotillin-Pbp2a complex, all by cryo-electron microscopy/tomography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electrocatalytic Gas-Phase Conversion of CO2 in Confined Catalysts' under Sixth Framework.

assistant: **Concept**

The technological objective is to demonstrate the feasibility of the electro catalytic gas-phase conversion of CO2 to Fisher- Tropsch (FT) like products (C1-C10 hydrocarbons and alcohols) as alternative innovative process occurring(i) in milder reaction conditions,(ii) starting from CO2 instead of CO and(iii) having a selective supplying of energy which allow the tuning of the product distribution. Scientific objectives of the projects are to(i) demonstrate the feasibility of the use of electro catalytic approach to improve the selective use of energy and tune/control the catalytic performances;(ii) develop novel functionalised nanotubes and demonstrate their use in developing novel electro-catalysts materials with possible potential applications in a range of other areas such as fuel cells, sensors, microtechnology;(iii) demonstrate the use of the concept of the confinement effect in nanomaterials to promote catalytic reactions;(iv) demonstrate the feasibility of combining catalysts and membranes (electrochemically driven) to develop new process options with possible potential applications in a range of other areas such as energy and chemical syntheses. Two alternative conceptual approaches are explored. The first is based on the gas-phase conversion of CO2 to FT-like products by reaction of protons (diffusing through a proton membrane) and electrons with CO2 on metal nanoparticles located inside nanotubes in order to have a confinement of CO2 (key concept to form FT-like products). The second approach is based on the same type of electrocatalyst, but using oxygen anion (O2-) conducting membranes to continuously subtract oxygen from the reaction environment and therefore reduce directly CO2 with H2 to FT-products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eco-Innovative Aquaculture System Training for European Industrial Doctorates' to be submitted under Horizon 2020.

assistant: **Abstract**

Aquaculture is the world fastest growing food production sector, providing over 50% of sea food, while capture fisheries remains static. However, there is increasing concern about its sustainable and profitable development. This challenge requires effective cooperation and communication between the academic and the private sector. The EASYTRAIN project tackles this challenge by developing innovative aquaculture systems based on the most modern techniques in the field of aquaponics using organic aquaculture feed formulas, which substitutes fishmeal by Spirulina and quinoa as filler. EASYTRAIN combines the expertise of two academic and four industrial partners from Spain, Portugal, the Netherlands and Italy, with complementary expertise in the field of plant and fish farming, feed production, aquaculture engineering and micro algae biotechnology. The outcome of EASYTRAIN will be 6 researchers with experimental and transferable skills ready to cope with the future challenges of the prospect aquaculture sector.


**Keywords:** Aquaculture, aquaponics, metabolic rhythms, chronobiology, organic fish feed, fish nutrition, fish welfare, microalgae, biotechnology, sustainable development, aquaculture engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biocatalysis for Sustainable Chemistry – Understanding Oxidation/Reduction of Small Molecules by Redox Metalloenzymes via a Suite of Steady State and Transient Infrared Electrochemical Methods' (BiocatSusChem).

assistant: **Concept**

Many significant global challenges in catalysis for energy and sustainable chemistry have already been solved in nature. Metalloenzymes within microorganisms catalyse the transformation of carbon dioxide into simple carbon building blocks or fuels, the reduction of dinitrogen to ammonia under ambient conditions and the production and utilisation of dihydrogen. Catalytic sites for these reactions are necessarily based on metals that are abundant in the environment, including iron, nickel and molybdenum. However, attempts to generate biomimetic catalysts have largely failed to reproduce the high activity, stability and selectivity of enzymes. Proton and electron transfer and substrate binding are all finely choreographed, and we do not yet understand how this is achieved. This project develops a suite of new experimental infrared (IR) spectroscopy tools to probe and understand mechanisms of redox metalloenzymes in situ during electrochemically-controlled steady state turnover, and during electron-transfer-triggered transient studies. The ability of IR spectroscopy to report on the nature and strength of chemical bonds makes it ideally suited to follow the activation and transformation of small molecule reactants at metalloenzyme catalytic sites, binding of inhibitors, and protonation of specific sites. By extending to the far-IR, or introducing mid-IR-active probe amino acids, redox and structural changes in biological electron relay chains also become accessible. Taking as models the enzymes nitrogenase, hydrogenase, carbon monoxide dehydrogenase and formate dehydrogenase, the project sets out to establish a unified understanding of central concepts in small molecule activation in biology. It will reveal precise ways in which chemical events are coordinated inside comple
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Energy innovative food process for production of high quality frozen foods' in the context of a Horizon 2020 call.

assistant: **Objectives**

COLDµWAVE aims to improve the research skills of Epameinondas Xanthakis by developing an innovative environmentally sustainable process for blanching and freezing vegetables with improved textural and nutritional quality at SP -Technical Research Institute of Sweden. The study which will be carried out will involve the use of microwave electromagnetic irradiation (MW) for blanching and freezing of vegetables. COLDµWAVE will develop tailored equipment for MW blanching of vegetables that has very high energy efficiency and no water consumption. Furthermore, this project will develop innovative pathways in freezing to improve the quality of frozen vegetables by exploring, in a new context, previous results acquired by the fellow. The developed process will lead to improved quality characteristics compared to the conventional freezing. During this extensive study the fellow will gain valuable multidisciplinary experience and new theoretical and practical skills in the areas of heat transfer modelling, energy accounting methods, food nutrition and quality measurements as well as life cycle assessment methods. The integrated proposed study will give the fellow the opportunity to develop further knowledge on development of innovative processes having industrial importance and finally become a real specialist in the microwave assisted food blanching and freezing. The candidate will also learn to conduct research, to manage projects, communicate results effectively, commercialise research, as well as an in-depth education in development of innovative processes which will contribute for an open mind to innovation and more successfully realisation of research ideas into commercial reality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The European image consortium for integrated molecular analysis of human gene transcripts' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

- To generate a minimal set of non redundant cDNA clones for most human gene transcripts and a master set of unique full-length cDNA clones representing 3,000 transcripts based upon the IMAGE Consortium resources (arrays of cDNA and CpG islands clones). - To characterize by DNA sequencing with high accuracy the complete sequence of the master set of 3,000 human gene transcripts (6 Mbases of finished sequence). - To obtain high resolution and comparative functional mappig localization in man and model organisms of 1,000 genes represented in the master set. - To develop the IMAGE Consortium Data Base to provide an easy access to an integrated view of the sequence, map and expression data generated.The general objectives of the European IMAGE Consortium are:- To generate a miniminal set of non redundant cDNA clones for most human gene transcripts and a master set of unique full-length cDNA clones representing 5,000 transcripts based upon the IMAGE Consortium resources (arrays of cDNA and CpG islands clones);- To characterize by DNA sequencing with high accuracy the complete sequence of the master set of 5,000 human gene transcripts (10 Mbases of finished sequence);- To identify positional and functional candidate genes involved in specific biological functions and inherited human diseases through high resolution and comparative functional mapping in man and model organisms of 1,000 genes represented in the master set;- To explore the transcription profiles of the genes represented in the minimal and master sets, and to produce 800 of the cognate proteins in order to explore their function;- To develop the IMAGE Consortium Data Base to provide an easy access to an integrated view of the sequence, map and expression data generated.The European IMAGE Consortium will work to c