RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identifying and characterising transmembrane transporters of tryptophan and kynurenine in normal and cancerous brain tissue', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The catabolism of the essential amino acid tryptophan (Trp) by tumour cells expressing either IDO1/2 or TDO has been associated with malignant tumour progression and poor patient survival.  Expression of these rate-limiting genes leads to both depletion of Trp and accumulation of the Trp breakdown product kynurenine (Kyn) in the tumour microenvironment.  Kyn has recently been shown to act as a ligand for the aryl hydrocarbon receptor (AHR), causing its nuclear translocation and resulting in expression changes which in tumour cells result in increased survival and motility, whilst in T-cells induce anergy and apoptosis.Although the membrane transport protein LAT1 is known to act as a Trp/Kyn exchanger, accumulating evidence from transport kinetics studies clearly indicate the presence of highly specific, as yet unidentified Trp and Kyn transporters.  Identifying the transport proteins responsible would offer a significant therapeutic target not only for aggressive, hard to treat brain cancers such as gliomas, but also in a number of neurodegenerative and auto-immune disorders in which the catabolism of Trp has been shown to be altered.I propose to do precisely this by expanding on discoveries I made during my studies of the role of the Trp catabolite 3-hydroxykynurenine in Huntington’s Disease, wherein I took advantage of unique features of Drosophila physiology to identify a number of candidate Trp/Kyn transporter proteins.  To fully realise the potential of my discoveries I should like to characterise the human homologs of these transporters in glioma culture and in vivo models, which will require me to change both my scientific field and model system.To gain the required expertise I am applying for an IEF to train with Michael Platten's group at the DKFZ in Germany, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Alcohol-induced arrhythmias studied by computational models of the human heart' to be submitted under Horizon Europe.

assistant: **Abstract**

Alcohol consumption is associated with an increased occurrence of arrhythmia and sudden cardiac death. Supraventricular arrhythmias, particularly atrial fibrillation (AF), are the most common arrhythmias associated with excessive alcohol intake, but ventricular arrhythmias have also been reported after alcohol intoxication. Alcohol-induced arrhythmias represent an increased healthcare risk for the patients, and if they do not self-terminate, hospital admission and subsequent cardioversion is necessary to restore the natural heart rhythm. Unfortunately, despite the known detrimental effects of alcohol consumption on human health and decades of extensive research in cardiac electrophysiology, the mechanism(s) by which ethanol promotes arrhythmias remain(s) poorly understood. This lack of knowledge considerably limits the ability to accurately identify individuals susceptible to alcohol-induced arrhythmias, and cardiac conditions that increase vulnerability to develop such arrhythmias. To unravel these mechanisms, the ALCOHEART project proposes a unique methodology that combines simulations in anatomically-accurate computational models of human atria and ventricles with the use of pharmacokinetic models that allow to simulate different alcohol drinking behaviours. The state-of-the-art computational models of atria and ventricles will allow to assess cardiac excitation and repolarization in 3 dimensions, and to characterize the contribution of ethanol to arrhythmia vulnerability in healthy and diseased hearts. Moreover, the simulations will allow to evaluate the role of different alcohol drinking behaviours between males and females, and of sex-specific differences in cardiac electrophysiology. Putting together leading experts in the field, the ALCOHEART project will offer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Resource efficient bio-chemical production and waste treatment', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The REBOOT project will create a disruptive wet waste valorisation technology where valuable resources are re-used rather than disposed of while tackling two urgent environmental challenges: nutrient circularity and climate change. Wastewater treatment sludge and manure treatment technologies are currently not satisfactory and there is no solution to efficiently re-use the resources it contains: phosphorous and carbon.The aim of REBOOT is to completely recover phosphorous from wastes while generating carbon neutral transportation fuels and a carbon sink in the form of carbon materials. The project will employ a frontier technology called hydrothermal liquefaction (HTL) which uses high temperature and pressure to produce a liquid product similar to petroleum termed bio-crude. This will be used for a range of innovative applications such as renewable aviation fuel, functionalized carbon materials and bio-bitumen.The possibility of complete phosphorous recovery in HTL is a completely new concept, previously thought impossible as only continuous HTL reactors can theoretically achieve this. The complex hydrothermal chemistry of salts can only be exploited on such advanced reactors that are currently beyond state-of-the-art. The specific objectives of REBOOT are: (1) mechanistic understanding of salt behaviour in multi-phase hydrothermal systems with the aim of full recovery. (2) Develop tailored strategies for in-situ jet fuel synthesis. (3) Establish microbial electrolysis cells for in-situ hydrogen production and nutrient recovery.REBOOT will be carried out on pilot continuous reactors, where the challenging physical conditions can be explored, exploited and new engineering solutions developed. If REBOOT is successful it will enable society to tackle existing waste problem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wool Worked Worlds - Studying industrial landscapes through collaborative filmmaking.' (WOOL), addressing dissemination and exploitation.

assistant: **Impact**

This study anthropologically investigates tensions within the transnational wool industry, a commercial network that emerged from European colonial projects that distributed sheep to the Global South’s grasslands. Wool production is an industry with a key paradox: it is highly industrialised yet cannot be detached from place-specific ecologies and social relations. Wool sheared from sheep is materially shaped by the geopolitical and ecological particularities of the grasslands where they are raised. This study explores 1) how these local diversities shape the global wool industry, 2) how local sheep rearing and landscape management practices are shaped by practitioners’ imaginaries of geographically distant parts of the wool industry. It develops a bottom-up approach to studying supply chains, attending to situated perspectives and knowledges of actors in three wool regions: Patagonia, Australia and South Africa. The approach deploys collaborative filmmaking as both method and analytical tool: the project engages sheep farmers, indigenous elderly, laboratory technicians and ambulant sheep shearers in the three regions, and businessmen at the Europe based International Wool Textile Organisation, in describing their version of global wool, analysing their own position within wool networks, and discussing how they understand the ‘globalities’ of the other sites. Building on previous work by the ER and conversations in visual anthropology, the project positions collaborative filmmaking as research practice, not dissemination. It also specifically explores connections and imaginaries that travel directly across the Global South (and not via European centres). Bringing in Global South perspectives, this project disrupts a notion of linear north-south axes and describes how a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'The Mathematics of Interacting Fermions'.

assistant: **Objectives**

The quantum many-body problem presents us with a baffling variety of phenomena whose mathematical understanding is just leaving infancy. One of the most prominent examples is the behavior of electrons in condensed matter: surprisingly, despite the presence of strong interactions between particles in the microscopic Schroedinger equation, on a macroscopic level one observes almost non-interacting particles. Moreover, some properties even turn out to be universal, i.e., do not depend on the details of the microscopic equation at all. Fermi liquid theory has been phenomenologically developed as an emergent theory to describe these correlation effects in systems of interacting fermionic particles. The first goal of this project is a rigorous derivation of Fermi liquid theory from the Schroedinger equation. My approach will be based on the analysis of high-density scaling limits. While the analysis of scaling limits has been tremendously successful in the last years for bosonic systems, in fermionic systems it has been restricted to the derivation of mean-field theories.  Recently I have developed an approximate bosonization for three-dimensional systems which can be rigorously applied in high-density scaling limits. This is one of the few tools that permit an analysis beyond mean-field theory, enabling us now to describe correlations without relying on perturbation theory. The second goal is to show that one-dimensional systems can be analyzed similarly but display a very different behavior called Luttinger liquid, demonstrating that the approach allows to distinguish Fermi from non-Fermi liquids. Thus I will not only provide a unified justification of the non-interacting electron approximation in two and more dimensions, but also pave a new way to and partially resolve the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SPELT, A RECOVER CROP FOR THE FUTURE EUROPEAN SUSTAINABLE AGRICULTURE' (SESA).

assistant: **Innovation**

TITLE SPELT IN EUROPEAN SUSTAINABLE AGRICULTURE ACRONYM SESA SUMMARY A coordinated research project is proposed which is aimed at fulfilling Objective 4.3 of the European 4th Framework Programme. The proposed work comprises a comprehensive investigation of a minor, traditional European hulled cereal crop - spelt. The research will include novel and generic studies to establish the genome of spelt, its differentiation from other cereals, its adaptability to contrasting European agricultural environments and its genetic improvement. The chemical composition, physical attributes and organoleptic traits of spelt will be determined in comparison with wheat, to establish fully the potential role of spelt in Europe. The main aims of the proposed project are to characterise the adaptability of spelt in countries where it is not grown traditionally, to demonstrate the practicability of growing spelt in less-favoured and environmentally- sensitive areas of Europe, to promote agricultural diversification in Europe, to improve knowledge of specific spelt quality traits for human consumption, to provide guidelines for new product development, to assess the properties of spelt as a feed for animals, to develop identification criteria to differentiate spelt from other cereals on a molecular basis, to characterise historic collections of spelt genetic material and to produce new cultivars of spelt with improved efficiency of use of resources. The work will be undertaken by a network of organisations, based on the exisiting European Spelt Network (ESN), from nine European countries representing the entire range of pedo-climatic, topographical, economic, and cultural conditions in Europe. The results of the research will contribute to the scientific knowledge of the inheritance of qualit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Linking micro- and macroevolution: macroevolutionary quantitative genetics of Drosophila wing morhology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The striking mismatch between evolution at short (microevolution) and long (macroevolution) time scales is a major remaining problem in evolutionary biology (the paradox of stasis). FLYWING will apply novel quantitative genetic theories and statistical methods to analyses of exceptionally high quality data to make a major step forward to solve the paradox of stasis.Working with Prof. Thomas Hansen at University of Oslo (UoO), I will test the idea that trait variance covariance structure (G-matrix) provides the conceptual bridge to link micro- and macroevolution (the multivariate genetic constraints hypothesis). The goals of FLYWING will be achieved through a novel multidisciplinary approach that combines quantitative genetic theory and state-of-the-art phylogenetic comparative methods (macroevolutionary quantitative genetics). I will apply this framework to analyze wing morphology data of the fly family Drosophilidae, collected by Prof. David Houle at Florida State University and available at UoO. The fly wing data consists of 37,668 exceptionally accurate individual observations across 111 Drosophila fly species. The data of such high quality has no close counterpart in any labs elsewhere in the world. The phenomenal dataset and my novel macroevolutionary quantitative genetic approach will make FLYWING the most rigorous test of the multivariate genetic constraints hypothesis to date.  FLYWING will give me the opportunity to receive top quality research training from two world leading authorities of quantitative geneticists (Prof. Hansen and Prof. Houle) to establish myself as an independent researcher at the forefront of evolutionary biology. Results from FLYWING will produce cutting-edge insights for issues at the interface between micro- and macroevolution. The conce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genomic Instability in Cancer and Precancer' (GENICA), addressing dissemination and exploitation.

assistant: **Impact**

Genomic instability is a characteristic of practically all human cancers. Recent results generated by members of this Consortium suggest that signs of genomic instability are evident from the very beginning of human cancer development, even in precancerous lesions. In these early lesions, the genomic instability affects primarily specific genomic loci, called common fragile sites. Because common fragile sites are very sensitive to perturbations in DNA replication, we proposed that cancer development from its very beginning is associated with DNA replication stress. A separate set of observations focused on telomeres and showed that short telomeres mimick DNA ends, activate the DNA damage checkpoint and promote genomic instability and cancer development. We propose here to study the role of DNA replication stress and short telomeres on driving genomic instability particularly in human precancerous lesions. Our studies will investigate the most common forms of cancer in the EU and will benefit from access to some of the largest databases of cancerous and precancerous lesions in Europe. Genomic instability will be explored using high resolution genomic arrays and the data will be correlated to clinical information on tumor progression. Further, analysis of proteins and genes involved in the cellular response to DNA replication stress and short telomeres will be explored using high throughput and targeted approaches and will be used to identify novel targets for cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Developing middle-range theories linking land use displacement, intensification and transitions' (MIDLAND).

assistant: **Innovation**

Land is a nexus for crucial societal and environmental challenges including food security, access to water, land degradation, biodiversity loss, and climate change. Development of solutions to balance these tradeoffs and synergies is currently hindered by the lack of theories explaining the conditions under which different pathways of land change occur and lead to different outcomes, integrating human and environmental aspects. This project will develop and test integrated middle-range theories explaining the linkages between three of the major processes in land systems, i.e., (i) land use intensification and expansion, (ii) land use displacement and trade, and (iii) land use transitions or regime shifts. The work will focus on the emerging agricultural frontier of Southern African dry forests and savannas, which is a threatened and understudied region, and its linkages with distant places.To overcome current limitations, the project builds on (i) experience in empirical, place-based studies, (ii) strong knowledge of social sciences and human-environment theories, (iii) rigorous inductive and deductive approaches to develop and test theories, and (iv) new ways to analyze linkages between distant social-ecological systems. We will analyze: (i) The strategic field of actors’ coalitions, institutions and distant linkages in emerging frontiers; (ii) Links between land use displacement, leakage, and local land changes; (iii) Pathways of agricultural expansion and intensification in tropical landscapes; and (iv) The conditions for transformative governance of land systems to foster resilient landscapes that sustain ecosystem services and livelihoods. These results will then be integrated to move towards the next generation of land system science, which will be able to develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New materials and eco-sustainable technologies for the conservation and restoration of textiles' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

There is a urgent need, jointly acknowledged by EU Member States and Macs, to preserve Textile Heritage. Hence, R&D project-TEXMED- intends: to find out appropriate and eco-sustainable solutions to problems of conservation and restoration of the Euro-Med Textile Heritage; to transfer the project results to the final users. Such ambitious targets will be achieved through: integration of research activities on advanced, different but complementary research topics, simultaneously considered and carried out by a multidisciplinary team; training of curators, restorers, etc. Thus, expected results are: new formulations and innovative technologies (free of toxic and/or harmful solvents) for the conservation and restoration of textiles; non-destructive methodologies for identifying nature, origin, colour, dye and manufacturing of fibres composing textiles; ad hoc treatments toward exhibition of textiles stored at Museums, Art Galleries, etc. in the Euro-Med Area