RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'TRACEability of Arbuscular Mycorrhizal fungi as plant-beneficial micro-organisms in agro-environments' in the context of a Sixth Framework call.

assistant: **Objectives**

Arbuscular mycorrhiza (AM) is probably the most important terrestrial symbiosis. AM fungi (AMF) supply the majority of land plants with nutrients and confer resistance against various stresses. Therefore, their exploitation is of high environmental relevance and economic value. Although demanded for safer food production, mass-production of AMF inoculum is still prone to contamination, and AMF cannot be traced in the field. Consequently, quality control is problematic and traceability in the agro-environment impossible.Our objective is to overcome the two major limitations of broad-scale exploitation of AMF,(1) Production of high quality inoculum - by developing bioreactor-cultivation and molecular identification tools as quality control system for AMF inoculum,(2) Ascertainment of plant-beneficial effects - by developing in-field molecular tracing tools, phylochips (taxonomic DNA micro-arrays).TRACEAM joins leading experts' knowledge about key technologies for AM research, as there are:1) ROC system as t he most advanced culture system, which will be the platform for development of bioreactors and molecular tools,2) DNA barcodes as identification tools based on specific sequences, which will constitute the base for the molecular identification of AMF, and also for quality control,3) DNA microarrays ('phylochips') construction (based on 5-10 'standard genes'), which will allow the detection of the active AMF community in the field,4) the obligate symbiotic endobacteria (>400 myr old 'integral component s' of AMF), which will be traced by phylochips to elucidate their role as targets for tracing and other (e.g. plant nutrition) aspects.Four PhD students will be hosted in institutes in Germany, Belgium, France and Italy, leading in the field of AM research. They get offer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Generation of an adverse outcome pathway network on cholestatic liver injury for mechanism-based in vitro testing of chemicals.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cholestasis refers to toxic bile acid accumulation mainly in the liver and can be induced by many chemical compounds, in particular drugs. At present, drug-induced cholestatic injury (DICI) is poorly predictable and is an important reason for drug withdrawal from the market as well as a major clinical issue. A solution lies in better understanding the mechanisms of DICI. A pragmatic tool to visually and rationally capture the mechanistic basis of toxic effects is the adverse outcome pathway (AOP). Current AOP constructs frequently provide a too simplistic reflection of the mechanisms underlying toxicity by underestimating initiating events and biological responses. This project aims to establish a realistic mechanistic scenario of DICI by producing an advanced AOP network that considers known initiating events of DICI and that quantitatively describes mechanisms of the adverse response as such as well as of the adaptive response activated by the body to counteract the adversity. This will be used as the basis for generating an in vitro test battery to accurately predict DICI. Such human-based and animal-free approaches to assess the safety of chemicals are urgently needed because of scientific and ethical reasons. AOP network development will rely on in vivo and clinical data collected from re-used samples (animal models of cholestasis and clinical cholestasis patients) and new in vitro data (human 3D spheroid model of cholestasis). This multidisciplinary and timely project will lead to a conceptual change in toxicology by introducing an innovative type of AOP network. Additionally, it will equally meet a ubiquitous medical need regarding the prediction of cholestatic liver toxicity, therefore, perfectly matching the objectives of this Work Programme. It is anticipated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Range Enclosure on the Tibetan Plateau of China: Impacts on Pastoral Livelihoods, Marketing, Livestock Productivity and Rangeland Biodiversity' under Sixth Framework.

assistant: **Concept**

This research investigates the biophysical and socio-economic impacts of policy-driven land use change in China's semi-arid regions. Range enclosure, livestock intensification and nomadic settlement is being implemented by the government at a scale involv ing millions of people and vast land areas.The rationale is to restore degraded land, prevent desertification and improve pastoral welfare. This project examines the performance and likely future success of these policies in meeting their goals. Measureabl e indicators will be compared of vegetation, livestock productivity, land use, household incomes and wildlife biodiversity in enclosed versus unenclosed management systems. Qualitative methods will evaluate social, cultural and economic repercussions. Part icipatory techniques involving local stakeholders will ensure incorporation of indigenous knowledge and local concerns. Technical innovations and best practices will be evaluated with stakeholders. Given the size of the Tibetan Plateau, changes in grazing intensity are internationally significant for understanding global climate change and carbon sequestration. Across the Tibetan Plateau, the project will compare regions representing five ecological zones in Sichuan, Gansu, Qinghai and the Tibetan Autonomou s Region. Field sites reflect the gradation of fencing intensity. A hierarchical research design begins with analysis of national policies, their application at local administrative levels, field site investigations of biological parameters at community l evel and, finally, detailed surveys of individual households and flocks. We hypothesise that no single system of grazing and rangeland tenure is optimal under all conditions in a heterogeneous environment constituting half of China's rangelands. Our goal i s to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Assessment and prediction of sediment dynamics within olive orchards' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The problem of soil erosion is well known and affects large part of the EU. Because of biophysical conditions, the Mediterranean region is among the most susceptible areas. Nevertheless, very little is known on past and present soil erosion rates in olive orchards, a land use type characterized by dramatic erosion rates but at the same time economically and socially very important in this region. Also, traditional erosion models do not perform well in such orchards because of the complex topography with tre e islands. This research proposal aims to assess and predict erosion and sediment deposition dynamics in olive orchards. Expected outcomes of the project are: (i) a thorough knowledge of sediment dynamics and its controlling factors within olive orchards, both at present as in the historical past; (ii) a model that can handle the particular situation within such orchards, based on lattice Boltzmann cellular automata models, to simulate these dynamics; (iii) assessment based on model predictions- of the efficiency of possible soil conservation measures, which can then be used to scientifically support policy decisions. The project will allow the solicitant, with a strong background in soil science and experimental geomorphology, to gain proficiency in modelling and computational flow dynamics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Concerted Action Polyp Prevention 2. A randomised controlled trial of colorectal polyp and cancer prevention using aspirin in carriers of hereditary non-polyposis colon cancer: HNPCC' under Fourth Framework.

assistant: **Concept**

Objectives:?CAPP2 will be the first randomized controlled trial to test the hypothesis that regular oral aspirin and/or resistant starch will inhibit colorectal adenoma development and growth in carriers of Hereditary Non-Polyposis Colon Cancer (HNPCC), a population at high risk of colon cancer. ?CAPP2 will disseminate advanced mutation detection techniques. ?CAPP2 will help to harmonize European HNPCC registries.Brief Description:Colon cancer is the commonest cause of cancer death after lung cancer. Environmental factors play a major role but in a significant minority genetic studies reveal an inherited predisposition. Recent studies have identified defects in mismatch repair genes in families with clinical features of hereditary non-polyposis colon cancer, which may account for up to 5% of colon cancer. Carriers of HNPCC are an ideal population in which to test preventive strategies; they are under regular follow-up, are motivated and are representative of the group most likely to follow future dietary or therapeutic recommendations.Carriers will be identified on the basis either of being a member of a known HNPCC family and having developed a typical tumour or following demonstration of a pathological mismatch repair gene defect. The aspirin hypothesis arises from a body of evidence including large scale epidemiological studies, animal studies, in vitro analysis of aspirin in colon cancer cells, and small scale human intervention studies using other non-steroidal anti-inflammatory drugs (NSAIDs) such as sulindac. Resistant starch is carbohydrate which reaches the colon undigested, there to be fermented to short chain fatty acids such as butyrate. Popuiations with a high starch intake have reduced colon cancer risks and butyrate is anti-neoplastic in vitro. A continui
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An Integrated Solution for Sustainable Care for Multimorbid Elderly Patients with Dementia' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

CAREPATH proposes an ICT-based solution for the optimization of clinical practice in the treatment and  management of multimorbid patients with Mild Cognitive Impairment or mild dementia. Such solution is targeting a more complex multimorbidity scenario and follows an integrated patient-centered approach, in order to develop a flexible and modular system to deliver a best care, adapted framework for increasing the independence and Quality of Life (QoL) of multimorbid patients with dementia.The proposed solution exploits the IONIS, C3-Cloud and imergo®-ICP healthcare platforms (whose three coordinators belong to the CAREPATH consortium) and provides a holistic environment for both healthcare providers and patients, efficiently addressing the joint multimorbidity and dementia challenges. To demonstrate and validate its results, CAREPATH will focus on combining multimorbid conditions, in different levels of complexity, and in combination with dementia. As such, CAREPATH will consider conditions such as Diabetes, Hypertension, Heart failure, Atrial Fibrillation, Chronic Obstructive Pulmonary Disease, Asthma, or Chronic Kidney Disease.The CAREPATH pilots will take place in four European countries (Spain, Romania, Germany and UK) with diverse health and social care systems, ICT landscape/digital maturity of healthcare provision and dementia national programs. The pilots will strengthen the evidence base on associated health outcomes and efficiency gains.CAREPATH will also elaborate on a methodology for computer  interpretable clinical guidelines and computationally derived best clinical practice for the improved management of elderly multimorbid patients with dementia. It will develop Quality Key Performance Indicators for such a guideline-driven clinical practice and patient
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Knowledge Based Bio-based Products' Pre-Standardization' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The application of standards and certification systems in the European bio-based product industry has positive long-term effects on the overall development of bio-based product markets. Trade barriers are reduced and the development of a pan-European market for bio-based products is promoted. Finally, public acceptance of bio-based products is increased through ensuring and verifying the sustainable sourcing of raw materials, the effective bio-content and clear indication of their (comparative) functionality in relation to the regular products. The KBBPPS project aims at increasing the uptake speed of standards and certification systems for bio-based products.This project covers research and demonstration on bio-based carbon content determination, biomass content methods not solely dependent on 14C-analysis and biodegradability and eco-toxicity test schemes. Next, identification and resolution of functionality related bottlenecks with the view to developing, harmonising and validating test methodologies will be undertaken. The possibilities for improving sample preparation, fractionation and thermal treatments will be studied in order to cover bio-base carbon and other bio-based elements determination. Next, practical solutions for stakeholders, lab and field tests on biodegradation or biological derived elements will be investigated. The goal in the end is that the results can be copied one-to-one into European standards.Following Mandates by the EC, the European Standardization Committee initiated a Technical Committee, CEN/TC 411. on ""Bio-based products"". By participating in this committee (its Secretariat being one of the partners), by exchanging with ASTM and ISO, and by doing pre- and co-normative research for them, KBBPPS will allow the European stakeholders to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety Of non-Steroidal anti-inflammatory drugs' (SOS) under Seventh Framework.

assistant: **Objectives**

The Safety Of non-Steroidal anti-inflammatory drugs (SOS) proposal aims to assess the relative cardiovascular (CVD) and gastrointestinal (GI) safety of non-steroidal anti-inflammatory drugs (NSAIDs). The NSAIDs are divided in traditional NSAIDs (tNSAIDs) and the newer COX-II inhibitors(coxibs). The aim will be fulfilled by a two-phase approach comprising systematic reviews and synthesis of CVD and GI risk information from clinical trials and published observational studies, followed by the design and conduct of a multi-country study in existing health care databases in the UK, Netherlands, Germany and France, comprising medical information on at least 35 million persons. A data ware house will be constructed that will contain all pre-specified and locally elaborated anonimized data from inception cohorts of NSAID users. Data elaboration is standardized through a common protocol that will be designed on the basis of information and knowledge gaps observed in the systematic literature reviews, plus information requirements for the statistical and decision models. The database study will yield risk estimates for CVD and GI bleeding for each individual NSAID by dose and duration and by other important effect modifiers (e.g. aspirin use). Separate models will be built for children since the indications and dosages differ and little is known on the safety of NSAIDs in this group as they are often prescribed off-label. Special emphasis will be put on the assessment and evaluation of methodological issues, such as confounding by indication, and outcome validity as these constitute the most important threats to the interpretation, robustness and perceived validity of observational studies. The results of the literature reviews, analysis of observational databases and re-analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GNSS User Forum on Navigation based Innovation for Farmers' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

UNIFARM sets up a user forum to present and defend the needs of farmers in the development of GNSS applications and services. UNIFARM brings together precision agriculture projects and farmers representatives from all over Europe. The project collect users requirements as well as user cases (motivations to invest) and harmonises them, to provide policy makers in GNSS evolution and other policy areas with their requirements. The project will also disseminate this and others information to improve awareness. Also, the project will provide a design facility based on the users cases to provide firms the opportunity to benchmark their innovative application or service. UNIFARM aims at setting up a sustainable network. The project therefore is connected to already established networks and platforms that may continue the user forum after the project lifetime. Setting up this user forum will enhance the scientific and technological excellence in GNSS in agriculture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EUWB - Coexisting Short Range Radio by Advanced Ultra-Wideband Radio Technology' (EUWB).

assistant: **Innovation**

Key objectives of EUWB are i) to explore the enormous economic potential of the ground-breaking Ultra-Wideband (UWB) radio technology, ii) to extend the UWB concept with advanced cognitive radio, multiband/multimode networking, and multiple antenna system concepts, iii) to enable the introduction of advanced services and competitive applications using the radio spectrum in a sophisticated manner.The advanced scientific and technical project work will be accompanied by activities in European and world wide regulation and standardisation bodies in which EUWB partners are highly committed. As a key for economic success of UWB, the project partners will continue to devote significant efforts to participation in CEPT ECC, IEEE, ITU, ETSI, and ECMA working towards consensus building and iterative improvement of the initial European and world-wide UWB regulation and standardisation.UWB technology enables gigabits per second short range communications and inherent precise real-time location tracking. Prominent examples to be implemented in the EUWB project are the Intelligent Home environment, the Public Transport environment, the Automotive environment and the Next Generation of Heterogeneous Public Access Network environment, following a strong demand from the mentioned industry sectors.EUWB is an industry-led initiative of 22 highly regarded industrial, consulting, and academic organisations. It builds on previous projects, such as PULSERS, and take into account stakeholders of the whole value chain. Major aim is to consolidate the technology advances in scientific areas related to UWB and to define system concepts for the envisaged four application areas. The results will be materialised in four application platforms built on the open UWB technology developed in EUWB. Besid