RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improvement of the economics of biomass/waste gasification by higher carbon conversion and advanced ash management - target action h (GASASH)' under Fifth Framework.

assistant: **Concept**

The project will focus on optimisation and improvement of biomass/waste derived fuel gasification process and utilisation of gasification ashes in order to improve the overall feasibility of biomass/waste derived fuel based energy production. The first stage of the project is the optimisation of the large-scale (fluid-bed) gasification process (improvement of carbon conversion reduction of ash volume, optimisation of use of additives). The second stage is focused on development of advanced components (ash oxidation and selective fractioning of fly ash) for the gasification process to increase carbon conversion further, reduce ash volume and improve ash quality in order to enable utilisation of gasification ash. Ash utilisation options will be screened and new methods will be developed based on ash qualities characterised in the project. Finally the techno economic feasibility of improvements will be evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Near Infrared Spectroscopy Tool for Collection Surveying' (SURVENIR) targeting Sixth Framework.

assistant: **Abstract**

Assessment of the state of archival, museum and library collections is a task of utmost importance. Depending on the type and size of a collection, surveying may also be one of the most demanding tasks in terms of the necessary resources. It is usually done using simple physical and chemical tests, often destructive, in order to reveal the collection condition, the general conservation needs and in order to plan preservation activities. As testing of a single item should take as little time as possible, the information obtained is usually only rudimentary.By providing a near-infrared-spectroscopic instrument prototype, the end-users will be provided with a powerful survey tool allowing reagent-less multi-component low-cost analysis of items. As the technique itself has recently found the way into industry as an in-line production control tool, and as a number of preliminary experiments have already been performed, the risk of its implementation for the purpose is low. Furthermore, the spectra can be taken non-destructively in a matter of minutes, then analysed using advanced statistical methods and as the result, data important for the preservation officer and policy maker may be provided, such as material composition and chemical state in a user-friendly software interface.The tool will be tested in seven collections, thus demonstrating the relevance of the developed approach. The involvement of an SME, a university lab and two libraries, three archives, and two museums, i.e. seven end-users, ensures an efficient and directed dissemination both of knowledge and of the developed technology.Surveying is indispensable in the sustainable impact assessment especially of protection treatments, and is the basis of all planning in collection management, so the project is highl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Egalitarian but not Equal: Sectoral Wage Formation and Gendered Wage Differentials' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

All over the globe, women in the work world receive, on average, 20% less than their male counterparts (United Nations, 2022). In countries explicitly committed to eliminating the gender pay gap (GPG), such as those in Europe, women still earn, on average, 13% less than men do (Eurostat, 2022). This is regardless of the fact that countries with persistent GPGs have deployed a strategic institutional measure to raise the wage floor of feminised work sectors and reduce the GPG – namely, collective bargaining.The overall aim of WAGE is to theorise the gendered nature of collective bargaining by investigating the past, the unruly present and the possible future of regulated collective bargaining processes in three key countries: Germany, Norway and Sweden. Moreover, the project’s research design will involve gathering data at the sectoral level of the metal sector and nursing and will use ethnographic research methods. To realise its overall aim, WAGE will accomplish the following three research objectives:1. Compare and synthesise existing histories of collective bargaining and the GPG in the three selected countries.2. Uncover and analyse daily practices in collective bargaining rounds that result in wage increases in the male dominated metal sector and the female dominated nursing sector.3. Document and explain how actors embedded in the male dominated metal and the female dominated nursing sector relate to the wage norm and sectoral gendered wage differentials.Given the dearth of scholarship on the relationship between gendered wage differentials and collective bargaining processes from an inter-sectoral angle, this study will be the first to systematically use qualitative methods to explore the economic frontier between sectoral gendered wage differentials and collecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INTERMITTENT ANDROGEN DEPRIVATION THERAPY IN THE ERA OF ANDROGEN RECEPTOR PATHWAY INHIBITORS; A PHASE 3 PRAGMATIC RANDOMISED TRIAL' in the context of a Horizon Europe call.

assistant: **Objectives**

Prostate Cancer is the most common cancer in European men. Despite dramatic improvements in early diagnostic and local treatment, one out of five prostate cancer patients will die from their disease. Despite progress in the past years, it remains critical to improve on the present strategy for advanced and metastatic prostate cancer. Within the proposed project, we will evaluate whether intermittent intensified androgen deprivation treatment (iADT) in metastatic prostate cancer is not inferior to continuous treatment in terms of oncological benefit while minimizing side effects and resource utilization and improving patient quality of life. The proposed clinical trial is designed to detect early if iADT has a negative impact on overall survival compared to continuous therapy. If successful, the outcomes of the project will define a new evidence-based standard of care for metastatic hormone sensitive prostate cancer. The proposed research could lead to improved patient survival and quality of life but also improve health system sustainability. This is a multidisciplinary and multistakeholder consortium involving clinical oncologists, surgeons, health economists and patient representatives. The study design was successfully discussed with patients. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.


**Keywords:** metastatic prostate cancer, quality of life, androgen therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A paradigm change in the treatment of blinding ocular diseases'.

assistant: **Innovation**

Ocular inflammatory diseases – affecting hundreds of millions of people worldwide – impose a significant medical and economic burden on society and can lead to blindness. Today, corticosteroids are the most common method used to treat ocular non-infectious inflammation of any kind. Rather than treating the disease itself, however, steroids merely relieve its symptoms, and long-term use can result in devastating consequences.Our bio-inspired drug candidate is a non-steroid. It approaches inflammatory diseases from within the immune system and was developed to ‘re-engineer’ the immune system. Based on excellent preclinical results, we believe that this approach will have the capability to disrupt the immune mechanism that causes the disease in order to provide patients with a safe and long-lasting therapeutic effect, with the goal of saving them from blindness. Our platform technology has the potential to effectively treat a broad array of autoimmune and inflammatory diseases and to become a first in class, market approved molecule for local treatment of inflammatory ocular diseases. Our first target indication is uveitic glaucoma – a devastating orphan disease requiring urgent treatment and carrying high risk of blindness. Selecting an orphan indication as a market penetration strategy will grant us extended market exclusivity, tax reliefs and shorter time to market. In the project, we will perform a Phase I/IIa clinical trial. We will exploit the trial results to secure financing for further clinical development towards commercialization. The global ocular inflammation treatment market is expected to exceed more than US$ 500 Billion by 2024. As our first target indication has a significant unmet need with no approved treatment, we expect to gain 25% of market shares 5 y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Exact Geometry Simulation for Optimized Design of Vehicles and Vessels'.

assistant: **Objectives**

This project focuses on computational tools for the optimized design of functional free-form surfaces. Specific applications are ship hulls and propellers in naval engineering and car components, frames, and turbochargers in the automotive and railway transportation industries. The functionality of these products depends on the shape of the surfaces, and even small variations may have significant impact. Our vision is that all computational tools are based on the same exact representation of the geometry. This will lead to huge benefits for the entire chain of design, simulation, optimization, and life cycle management. For several reasons, an exact representation of the geometry is essential. The errors introduced by approximating the geometry may falsify the simulation results in challenging applications. This becomes even more important if the simulation is to be used as part of an optimization loop for goal-based design. Multi-physics models, such as fluid-structure interfaces, demand for exact interfaces. There exists a “great divide” between the CAD (Computer Aided Design) approaches for modeling complex geometries and the numerical simulation methods (FEM). The idea of bridging this gap has gained significant momentum by the introduction of isogeometric analysis (IA) by US-based researchers. The application and extension of IA to core components of vehicles and vessels is especially rewarding since with respect to functional free-form surfaces, the existing simulation and optimization methods are at the limit of their capabilities. The strategic objectives of the proposal are: (1) To establish a new class of computational tools for fluid dynamics and solid mechanics, simulations for vehicles and vessels based on IA, (2) To achieve seamless integration of CAD and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'AI-Optimized Control and Integration of Transcritical R744 Heat Pumps for Sustainable Heating Solutions'.

assistant: **Innovation**

The heating sector is a critical challenge in the global transition toward a low-carbon society, particularly for hard-to-abate applications requiring substantial energy (e.g., residential applications). Among various green technologies, transcritical R744 (CO2) heat pumps have emerged as a future-proof solution thanks to their eco-friendly and safe refrigerant (i.e., R744). On the one hand, R744-based heating systems can reduce dependence on fossil fuels, including Russian gas, especially by integrating renewable energy sources (RESs) and hot thermal energy storages (HTESs), enhancing resilience to energy price fluctuations. On the other hand, its energy and economic performance is hindered by suboptimal control between the heat pump and heat distribution/domestic hot water system, which becomes more complex when integrating RESs and HTES. Thus, the AI-Heat Pump project aims to develop and demonstrate the first ever artificial intelligence (AI)-driven real-time optimization algorithm to allow R744-based heating systems integrated with RESs and a HTES to always operate at the highest cost-effective conditions. The algorithm will be implemented with respect to RES availability, HTES status, heating demand, heat pump/heat distribution status and, electricity price and it will be tested on the transcritical R744 heat pump setup at SDU. Compared to the heat pumps using conventional refrigerants, i.e., synthetic refrigerants often classified as PFAS and/or slightly flammable, the algorithm will allow R744-based heating systems to be about 15 % more cost-effective in multi-family houses. The project will be carried out in close collaboration with the University of Edinburgh (HTES modelling) and Bitzer Electronics A/S (enhanced system control and integration). Therefore, as co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'VISIBLE LIGHT MEDIATED CARBONYLATIONS' (VISTA-CARB).

assistant: **Concept**

The present proposal aims to develop a sustainable reaction methodology to expand the current scope of carbonylative couplings using sunlight and organic (metal-free) dyes. The planned activities are at the interfaces of photophysical, organic synthetic, and technological studies. Two novel chemical concepts are proposed: i) the use of available and reactive gases, such as carbon monoxide, for the synthesis of organic intermediates and fine chemicals via photo-redox methodology using visible light as the most abundant energy source, and ii) the development of two-photon processes for the activation of hitherto unreactive organic halides by visible light. To achieve these objectives, we will initially focus our studies on visible-light mediated photo-redox functionalizations of simple arenederivatives with common nucleophiles and study appropriate organic photocatalysts under carbon monoxide atmosphere. Secondly, light upconversion processes (from mid-VIS to high-energy VIS and near-UV) will be evaluated toward the photo-redox activation of sigma-bonds (i.e. in aryl bromides) that lie outside the energy window of the primary irradiation wavelength. We will apply such methodology to novel synthetic carbonylations which result in the formation of various industrially relevant benzoate, phenone, and chalcone derivatives. Finally, commercial microflow reactors will be equipped with a transparent reaction chamber in order to demonstrate the potential of the combination of photo-redox and high-pressure methodologies for continuous synthesis. Both concepts rely upon high dispersion and rapid mixing, so that microreactors contribute to the overall reactivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Evolutionary Consequences of Arrested Genomic Conflict in Asexual Species' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Genomic conflicts are major drivers of evolutionary innovation and play an increasingly recognized role in human disease. Intra-genomic conflicts arise because self-promoting elements such as driving centromeres or transposable elements (TEs) can spread in a population without increasing the fitness of their carriers. Inter-genomic conflicts arise when genes have opposite fitness effects in different carriers, as is the case for genes underlying traits with distinct optimal values in males and females. Here I propose to use asexual species as a novel system to studying intra- and inter-genomic conflicts. Because there is no recombination or segregation under asexual reproduction, intra-genomic conflict disappears as the interests of all genetic elements become aligned with those of their host. This allows us to test the predictions that intra-genomic conflict drives the evolution of TE virulence, centromeres, and centromere-binding proteins. Furthermore, because asexual species are comprised of only females, male phenotypes are no longer under selection and sexual conflict over optimal trait values therefore disappears. This proposal leverages the replicated loss of conflicts in independently evolved asexual lineages of Timema stick insects to identify conflict driven aspects of genomic and phenotypic evolution in sexual species. Because Timema have an XX:XO sex determination system, males can be recovered from asexual lineages via X-chromosome losses. This allows for the study of male reproductive traits, sexual dimorphism and sex-biased gene expression in species where selection has been acting solely on females for prolonged time periods, and for the identification of traits and biological processes subject to sexual conflict. By combining phenotypic, experimental an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and implementation of Grouping and Safe-by-Design approaches within regulatory frameworks' (2014-2020).

assistant: **Concept**

One of the greatest challenges facing regulators in the ever changing landscape of novel nano-materials is how to design and implement a regulatory process which is robust enough to deal with a rapidly diversifying system of manufactured nanomaterials (MNM) over time. Not only does the complexity of the MNM present a problem for regulators, the validity of data decreases with time, so that the well-known principle of the half-life of facts (Samuel Arbesman, 2012) means that what is an accepted truth now is no longer valid in 20 or 30 years time. The challenge is to build a regulatory system which is flexible enough to be able to deal with new targets and requirements in the future, and this can be helped by the development and introduction of Safe by Design (SbD) principles.   The credibility of such a regulatory system, underpinned by the implementation of SbD, is essential for industry, who while accepting the need for regulation demand it is done in a cost effective and rapid manner. The NANoREG II project, built around the challenge of coupling SbD to the regulatory process, will demonstrate and establish new principles and ideas based on data from value chain implementation studies to establish SbD as a fundamental pillar in the validation of a novel MNM. It is widely recognized by industries as well as by regulatory agencies that grouping strategies for NM are urgently needed. ECETOC has formed a task force on NM grouping and also within the OECD WPMN a group works on NM categorisation. However, so far no reliable and regulatory accepted grouping concepts could be established. Grouping concepts that will be developed by NanoREG II can be regarded as a major innovation therefore as guidance documents on NM grouping will not only support industries or regulatory age