RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of SOMO Catalysis Towards the Synthesis of Complex Steroidal Frameworks' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This proposal describes methods for enantioselective organocatalytic radical cascade polycyclisation reactions based on using the newly discovered techonology of SOMO catalysis. The past 8 years has seen tremendous progress in the field of organocatalysis.  In particular the advent of both LUMO lowering imnium ion catalysis and HOMO raising enamine catalysis has seen the development of more than 60 new asymmetric methodologies.   Very recently, the MacMillan group disclosed a new strategy which provides alternative reactivity compared with enamine or iminium catalysis.  It was realised that the intimate equilibrium between enamine and iminium intermediates can be interrupted chemically by a single electron oxidation to form a 3pi-electron species containing a singly occupied molecular orbital (SOMO).  This radical cation species was found to be capable of the typical reactivity pathways associated within the realm of radical chemistry and allowed access to a previously unknown set of organocatalytic transformations. This methodology is proposed to be applicable to the formation of multiple carbocyclic rings where the catalyst triggers an initial cyclisation resulting in a cascade reaction to form a complex steroid like framework. A biologically active steroid also has been identified as a target for this methodology. This possesses a interesting biological profile and potency against certain cancer cell lines.  The methodology will also be flexible enough for analogue synthesis with the aim of discovering more potent compounds with potential for the treatment of cancer. In the return phase the applicant will study in the field of C-H activation which will compliment his training on the forefront of synthetic chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Book History and Translation History: Copyright, Wages, Censorship, and the (Proto-)Professionalisation of Translators in Nineteenth-Century Britain and Ireland' (Proto-), addressing dissemination and exploitation.

assistant: **Impact**

Hosted at the School of Advanced Study (SAS), University of London’s prestigious research-intensive institution that brings together nine research institutes, the Fellowship will address and exploit the synergies between book history and translation history by combining the researcher’s perspective in the area of translation studies with the expertise and resources available at SAS in the field of book history. Based at the Institute of English Studies, which specializes in the history of the book, manuscript and print studies, the researcher will be able to draw on the expertise of her supervisor, Dr Andrew Nash, Reader in Book History, Deputy Director of IES, and Director of the London Rare Books School. The project will generate new knowledge about the production of English-language translations in the nineteenth century by investigating the relations between translators and their publishers and the “proto-professionalisation” of translators in Ireland and Britain, in a century marked by large-scale changes in print culture and by the increasing professionalisation of authors. The research will draw on a number of key publishers’ archival records, principally at the British Library and University of Reading. Addressing a lacuna in the history of the book, the project will provide much-needed insights into the working conditions and social circumstances of translators, both male and female, paying special attention to copyright, censorship and translators’ remuneration.Supported by an international and multidisciplinary team of academic specialists, including the Institute of Modern Languages Research, the Fellow will expand her research and professional network through dissemination activities and engagement with academic, professional and wider publics. Formal train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Selective Tape-Laying for Cost-Effective Manufacturing of Optimised Multi-Material Components' (STELLAR) targeting Seventh Framework.

assistant: **Abstract**

The aim of the Stellar project is to develop the manufacturing process for high-speed placement of carbon, glass and polymer fibre reinforced matrices, in selected locations in a composite structure, to provide the optimum reinforcement, weight and cost profile within a part.The use of composite materials in structural components is becoming well established in a range of applications, and the materials can offer significant benefits in mechanical properties, weight and through-life environmental impact. However, whilst some hybrid structures do exist, these are typically combinations of relatively isotropic materials, which only go part of the way to optimising the amount of materials used in the structure. The ideal structure has different combinations of composite materials in predetermined locations in a hybrid multi-material structure, but to date this has not been achievable because cost-effective manufacturing processes have not been available.The concept of this project is therefore to develop the design methodologies, manufacturing processes, equipment and control systems needed for localised placement of different fibre-reinforced thermoplastic composite tapes onto different substrates, creating locally reinforced components that are fully weight-optimised.  To achieve this, the project will focus on development of the Automated Tape Laying (ATL) process to selectively place reinforced thermoplastic tapes in 3 manufacturing routes:• Selective reinforcement of existing components• Direct additive manufacture of components• Manufacture of selectively reinforced tailored blanks for compression mouldingThe manufacturing process developed will have a significant effect on the weight of structures, as for the first time it will allow different reinforcement fibres (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design Study for the LIVING LAB Research Infrastructure, to research human interaction with, and stimulate the adoption of, sustainable, smart and healthy innovations around the home' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of this design study is to address all key issues related to the feasibility of a new research infrastructure with a clear European dimension, named LIVING LAB, that will: • Advance the field of user centred research (i.e. by studying the interaction of people with innovations for the home), • Test, evaluate and improve innovations for the home, • Foster societal needs such as sustainability and quality of life, • Stimulate competitiveness of European industry (that brings these innovations to the market). LIVING LAB will bring together Europe’s top research institutes and companies to study the interaction of people with technology in the home environment, and to stimulate cooperative projects in the fields of user centred research and product development. A LIVING LAB-core infrastructure will look like an ordinary house, but (invisible to its inhabitants, who are all volunteers) it will have sensors, cameras and microphones that record every aspect of home life. The behaviour and interactions of the volunteers can be monitored at any point in the day throughout the duration of their stay. One key advantage of the LIVING LAB over other simulation setups is that products can be evaluated in a real-life environment, over a prolonged period of time. This way, researchers and product developers can achieve a deeper understanding and uncover valuable insights about how people interact with products, leading to the development of better products, with real benefits for consumers and a better chance of succeeding in the market. In particular, the LIVING LAB will focus on sustainable and quality-of-life-enhancing innovations. As the LIVING LAB research infrastructure will be made up of several LIVING LAB-centres and affiliated research institutes and corporate la
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis' (DIABIMMUNE), addressing dissemination and exploitation.

assistant: **Impact**

Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 1600 children at the age of 3 and 5 years and by observing a birth cohort comprising about 320 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fully automated cell-free DNA extraction and quantification - liquid biopsies safely from Patient to Lab' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Liquid biopsies are blood tests with growing potential in diagnostics for cancer and prenatal screening. Pre-analytical challenges, such as the need for skilled workforce and strict logistic requirements for samples transportation, are limiting the full exploitation of the method. To address these technical issues, we developed a method for immediate and automated sample processing that provides a sample with higher reliability, less human labour, and less transport requirements. BiopSense innovation is a fully automated disposable cartridge, where the blood is filtrated using a dedicated hollow fiber membrane and then cfDNA is isolated from the plasma in the microfluidic system. The resulting sample can be then transported by regular post and eluted at the destination to carry out the final analysis. The cartridge is controlled by a control unit composed of a vacuum generator, software, and a simple spectrophotometer. In this EIC Transition project our objectives are to validate the automated cfDNA extraction technology and to integrate all the features of the innovation in a single disposable cartridge, which will be ready for marketing, licensing and IVD validation by the end of the project. The cartridge design will be done in close collaboration with the potential customers sector (biotech companies and hospital laboratories) to use their feedback to develop the user interface, manufacturability, and regulatory compliance. The project will focus on the cartridge design and will outsource control unit development to a company with experience in vitro diagnostic devices designing and production. In this project the commercialisation strategy for the next 5-10 years will be developed to define how our start-up company BiopSense will handle the disposable cartridge des
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A-SMGCS Testing of operational procedures by simulation' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The ATOPS project has been set up to reach several objectives. These are :1. %The first objective, related to the definition of operational procedures will bemet by :£ defining a list of ATC procedures based on the use of an A-SMGCS£ testing a limited number of these procedures in a simulated busy airport environment (such as Heathrow, Schiphol),£ identifying benefits arising from the use of such procedures.The second objective, related to performance parameters, will be met by carrying out tests of some new A-SMGCS based operational procedures in such a way that data can be derived and used in the process of defining sub-systems and equipment performance parameters.The third objective, related to the validation of simulation means, will be met by demonstrating through test scenarios similarities between the simulated and real world operations.The fourth objective, providing a baseline for the 5th FWP, will be met by the preparation of a report outlining testing that could be usefully performed in the context of the 5th FWP.The last objective, consulting and/or informing all interested parties, will be met by setting up internal consultations and two forums. Forum 1 is a consultation forum and will be set up prior to the start of the simulation to consult end users and Forum 2 is a dissemination forum to inform end-users, equipment providers and regulatory authorities on the results of the simulation.. %DEFAMM, SAMS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular Quantum Heat Engines', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Heat engines are an integral part of our daily lives. They power cars or produce electricity by converting heat into work. Increasing their efficiency is very difficult and only marginal improvements have been achieved over the last decades. Thus, to reach the ambitious climate goals, it is necessary to go beyond conventional technologies. Atom-sized systems where quantum mechanical effects come into play could enable this: theory predicts that their efficiency can be boosted beyond the classical limits imposed by thermodynamics. However, so far, this has not been tested in practice due to a lack of suitable model systems.I propose to build a molecular heat engine of only a few atoms in size, with such high control over its structure and properties that these predictions can finally be tested. The engine's quantum properties will be robust at experimentally accessible temperatures, its coupling to the environment will be controllable, and electrical transport through it will be quantum coherent. I seek to exploit the full gamut of their physical properties to boost efficiency, including spin entropy and vibrational coupling. Practically, I will 1) implement a scanning probe setup into a dilution refrigerator, 2) fabricate single-molecule junctions with micro-heaters and ultra-sensitive superconducting thermometers, and 3) perform and interpret caloric experiments on single molecules at unprecedented precision.The results will teach us about the fundamental properties of atom-scale quantum systems and heat flowing through single molecules. It will inspire new ways to increase the performance of thermoelectric applications such as waste heat harvesters, nanoscale spot-cooling devices, or even thermal rectifiers and transistors.I am one of the forerunners in molecular ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ecosystem-based Responsive Fisheries Management in Europe' (ECOFISHMAN), addressing dissemination and exploitation.

assistant: **Impact**

EcoFishMan seeks to develop a responsive fisheries management system (RFMS) based on results-based management (RBM) principles. The intended context of application of the RFMS is complex, mixed-fisheries and multi-stakeholder fishery sectors like those found in the EU/Common Fisheries Policy (CFP) area. It will be an ecosystem-based sustainable management system under a precautionary framework that will define maximum acceptable negative impact, target elimination of discards and maintain economic and social viability. EcoFishMan is a multidisciplinary project, involving scientists and stakeholders in activities relating to biology, stock assessment, technology, economy, sociology and legal aspects of fisheries management. The work starts with a review on existing results-based management systems (RBMS), the CFP and tools that aid fisheries management. The next step is identification of outcome targets and development of relevant indicators, which are then visualised through development of a GIS based decision support tool. The RFMS will be designed, developed and evaluated in collaboration between scientists and stakeholders and tested through simulated case studies. This will take place in an iterative process (spiral model) to ensure that the RFMS is adaptive to different types of fisheries and changes in the environment. A roadmap will be produced for the implementation and maintenance of recommendations in the system. In the RFMS, stakeholder involvement is essential and through their active involvement in the development of the system, EcoFishMan aims at improving cooperation and mutual understanding between scientists, policy makers and other stakeholders. Top-down management strategies will be combined with a co-management and bottom-up approach that aims to shi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The first affordable and easy-to-use IoT system that tracks pill intake with printed circuits technology' (SIGUEMED).

assistant: **Innovation**

SIGUEMED is provides the first cost-effective and convenient solution to an unsolved world-wide problem of massive economic and societal impact: the non-adherence to medication of chronic poly-medicated patients.Low medical adherence represents a heavy burden for the EU28 in terms of:-Cost due to extra medical treatment that needs to be given and to additional hospitalisations: estimated at 125,000 M€/year.-Premature deaths that could be avoided with correct adherence to medication: over 200,00 citizens/yearCurrently there are several solutions that attempt to increase medication adherence, but none of them reaches a sufficient market penetration because they are not useful enough or do not fully meet user demands. To bridge that market gap, we have developed SIGUEMED. SIGUEMED is an IoT eHealth solution aimed at fostering and monitoring medical adherence in a disruptive way. By combining a smart personalized blister pack with printed circuits in its foil (key enabling technology), wearables connected via Bluetooth to the base dock and a SW platform, we are able to remind to the patients intake the time for the intake of pills, and to track if and when this intake has taken place. If there has been any breach in the intake, a cascade of alerts is sent to contact people (relatives, caretaker, pharmacists). Access to track records and monthly reports is also possible. SIGUEMED is especially user-friendly, even for digital immigrants. To commercialize SIGUEMED we will create a network of associated pharmacies, which will be our clients and will shape our network of authorized distributors. They will sale and provide SIGUEMED’s associate services to poly-medicated patients, which are the end-users. After five year of commercialization, we expect to have built a network of m