RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hybrid nanocrystals exhibiting advanced and tailored properties' in the context of a Sixth Framework call.

assistant: **Objectives**

Colloidal nanocrystals (ncs) are attractive building blocks to new materials with tuneable chemical and physical properties and with enhanced technological added value. Nanocrystals with controlled shape and composition, which represent an even newer generation of materials, increase the functionality of the particles by combining together different properties (optical, magnetic, electrical) in a single object (multi-modal capability). To deepen our fundamental understanding of the control of these systems it is necessary to develop reliable synthetic routes to these hybrid ncs.This will be possible through a synergy of novel synthetic approaches, advanced tools of structural analysis and theoretical methods that model the growth and physical behavior of ncs. These hybrid ncs will exhibit novel functionalities arising from the properties of the individual components and from their interactions. In addition, organic molecules will be selectively linked to well-defined regions of each nanoscale motif and then used to create ordered assemblies. These materials will play a central role in many technological areas, which will employ the knowledge gained in this program, with clear impact for the future of nanotechnology in Europe.Since the techniques and methodologies proposed herein include a high degree of innovation, their adoption and exploitation by industry will demand new job openings, a particular favourable issue for less-favoured geopolitical regions of EU, such as Greece. It is apparent that the synthesis and characterization of these hybrid nanostructures requires a combination of advanced, multidisciplinary methods and technologies, some of which have been independently developed in European Laboratories. The project aims to transfer the required know-how from c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Methodology for establishing a database on transport supply, demand and modelling in Europe' under Fourth Framework.

assistant: **Concept**

To develop a methodology for the establishing of general European databases on passenger, goods and traffic flows. The methodology will address the establishing of the framework of the database as well as supply a procedure for estimation of those variables which are urgently missing in the database. The database will cover the EEA + Switzerland, and take into account a progressive inclusion of the CEEC/CIS countries.A zoning system for the structuring of actual transport flows by way of spatial aggregation into major transport corridors and networks will include interregional flows within EEA + Switzerland, flows in and out of the EEA, flows connected to the CEEC/CIS, as well as important external sea links. It must also be possible to distinguish transit flows from flows between neighbouring countries.The project will furthermore be geared to the needs for more permanent solutions to transport infrastructure information, given the insight already gained in other tasks whether already finished or still running. The project also aims at establishing sets of methods for creating a European database on Transport Infrastructure. Also here the database will cover EEA + Switzerland, and take into account a progressive inclusion of the CEEC/CIS countries. The combination of transport flows with network data is essential to the understanding of transport. Through the project this combination will be emphasised. Thus the perspective on infrastructure is the European context, although the research will not be restricted to information about TEN, while much of the existing, relevant data aims at national needs. How to overcome this problem will be a very important result from the project.Links with other projects, tasks, areas, programmes, policy actions:Tasks 1.1.1/1, 1.1.1/2, 1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Intracellular ERK signalling dynamics mediated epidermal stem cell fate control' in the context of a Horizon 2020 call.

assistant: **Objectives**

Understanding how stem cells maintain homeostasis in the epidermis is of great interest to regenerative medicine. Previous studies have identified the crucial role ERK signalling plays in coordinating homeostasis. Intriguingly, and somewhat paradoxically, ERK signalling has been shown to regulate divergent epidermal stem cell outputs; from maintenance, to commitment, and terminal differentiation. Uncovering how the activity of a single signalling pathway can regulate such divergent responses can not only allow us to robustly control epidermal stem cell behaviour but will also have far reaching implications for both the fields of stem cell and cancer biology. Importantly, ERK signalling manifests in a dynamic/pulsatile manner, and these dynamics have been shown to encode information in other epithelial cell lines. If ERK dynamics can encode information that regulates the divergent outputs of epidermal stem cells remains to be explored. My goal is to employ an interdisciplinary approach that combines electrical, and biomedical engineering approaches with those of stem cell biology to decipher the information encoded in the dynamics of ERK signalling that control epidermal stem cell outputs. To achieve this, I will first identify ERK activity signatures associated with the different cell states of the epidermis (stem, committed, and differentiated) using live primary human epidermal cells expressing a Förster Resonance Energy Transfer based ERK reporter. I will then decode these signatures using quantitative Fourier analysis to identify the key amplitude and frequency parameters associated with each epidermal cell state. Further, these parameters will then be tested for their ability to maintain the associated states under experimental conditions that enable control of ERK
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Axes de recherche pour l'elaboration de nouveaux outils et modèles permettant d'évaluer la contribution de l'aquaculture et de la pêche au développement' (AXES).

assistant: **Concept**

The first objective of the project AXES was to carry out a synthesis of the various methods currently available and reported in the literature and to evaluate the socio-economic contributions of fisheries and aquaculture activities to regional development. Although the report reviews a large number of different methods or instruments, particular emphasis is given to the methods derived from Input-Output (I-O) tables approach and its extension, the Computable General Equilibrium (CGE) model. This is because I-O tables have been the prime tools used to carry out the most recent studies in Europe (COWI 1997, MegaPesca 1999) and they appear therefore to be directly relevant to the AM main objective. On a more fundamental basis, the literature review shows that I-O and CGE models are also the reference tools suggested in peer-reviewed journals and used by international development agencies (World Bank, OCDE, etc) to evaluate the impacts of policies on economic sectors, industries, or specific geographic areas (countries, regions).The second objective of AXES was to draw upon these various documents in order to identify research orientations that may lead to the development of new methodologies and tools pertinent for:The evaluation of the socio-economic contributions of fisheries and aquaculture activities within coastal regions; and The evaluation of the interrelationships of these activities with components of other economic sectors in the region considered.The Accompanying Measure AXES is a contribution towards the evaluation of the role of fisheries and aquaculture activities within the economies of the regions where structural measures may be implemented.Chronologically this Accompanying Measure (AM) follows a series of studies commissioned by the EU, which were aimed a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Generation of mice transgenic for killer cell hla class i receptors' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and contents NK cells express on their surface receptors for MHC class I proteins (KIR). Engagement of these receptors inhibits NK cell cytotoxic programs. KIR can be expressed on T cell subsets and their engagement also results in inhibition of effector functions by the CD3-TCR complex. The aim of my proposal is to investigate the mechanisms of activation and/or inhibition of natural cytotoxicity with an in vivo" model. In particular I would like to generate mice transgenic for a class of KIR, the p58 molecules and their natural mutant p50, which specifically recognize HLA-Cw3. The transgenic mice for p58/p50 molecules will be a unique model for the study of KIR role in NK cell ontogeny of the repertoire of NK cells in these mice and of the dissection of the mechanisms controlling T and NK cell activation/inhibition programs. Training content (objective, benefit and expected impact) My project is a part of a collaboration on NK receptors for MHC class I molecules-between the laboratory directed by Prof. L. Moretta in Italy and the one directed by Prof. E. Vivier in France. Since the Centre d'Immunologie de Marseille-Luminy has a long experience in "in vivo'' investigation using transgenic mice, I will easily conduct my project and I will be able to learn a highly specialized technique than can be very useful for my professional experience. Links with industry / industrial relevance (22) "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'High-Q metasurface sensor for rapid on-site PFAS quantification in water'.

assistant: **Concept**

Per- and polyfluoroalkyl substances (PFAS) are synthetic, bio-accumulative chemicals extensively used in industrial and consumer applications. Their extreme persistence has led to widespread, uncontrolled presence in water, soil, and even human blood. Proven links of PFAS to serious health effects, including cancer, immune dysfunction, and reproductive toxicity, have prompted increasingly strict regulations from the U.S. Environmental Protection Agency and the European Chemicals Agency. Growing awareness of these risks, confirmed by the steady expansion of the PFAS testing market (USD 781.25M in 2023 to USD 1330.27M by 2030 with a CAGR of 7.9% from 2024 to 2030), is fueling demand for accurate detection solutions, supported by recent unprecedented advances in quantification technologies. The current gold standard, Liquid Chromatography Tandem Mass Spectroscopy, meets the stringent regulatory requirements, but is costly, needs trained staff and complex sample preparation, and remains confined to centralized laboratories with turnaround times of hours to days. Yet utilities, regulators, and remediation teams need on-site results in minutes to shift from pure reactive monitoring to proactive intervention. Nanomaterials are at the forefront of next-generation sensing technologies. In particular, optical metasurfaces, i.e. nanostructured films only a few hundred nanometers thick with unique optical properties, are poised to transform a wide range of applications, including environmental monitoring. Despite these exceptional promises, the few market-ready nano-enabled options face several major limitations, and fail to meet the urgent field needs. Within META-SENSE, we will conduct a technical and commercial feasibility study of a compact, regenerable, label-free nanosensor b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Ecology of Antibiotic Resistance' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Main goal. We aim to understand the puzzling coexistence of antibiotic-resistant and antibiotic-sensitive species in natural soil environments, using novel quantitative experimental techniques and mathematical analysis. The ecological insights gained will be translated into novel treatment strategies for combating antibiotic resistance.Background. Microbial soil ecosystems comprise communities of species interacting through copious secretion of antibiotics and other chemicals.  Defence mechanisms, i.e. resistance to antibiotics, are ubiquitous in these wild communities. However, in sharp contrast to clinical settings, resistance does not take over the population.  Our hypothesis is that the ecological setting provides natural mechanisms that keep antibiotic resistance in check. We are motivated by our recent finding that specific antibiotic combinations can generate selection against resistance and that soil microbial strains produce compounds that directly target antibiotic resistant mechanisms.Approaches.  We will: (1) Isolate natural bacterial species from individual grains of soil, characterize their ability to produce and resist antibiotics and identify the spatial scale for correlations between resistance and production. (2) Systematically measure interactions between species and identify interaction patterns enriched in co-existing communities derived from the same grain of soil. (3) Introducing fluorescently-labelled resistant and sensitive strains into natural soil, we will measure the fitness cost and benefit of antibiotic resistance in situ and identify natural compounds that select against resistance. (4) Test whether such “selection-inverting” compounds can slow evolution of resistance to antibiotics in continuous culture experiments.Conclusions. These find
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'AGFORWARD' (AGFORWARD) targeting Seventh Framework.

assistant: **Abstract**

Agroforestry is the practice of deliberately integrating woody vegetation (trees or shrubs) with crop and/or animal systems to benefit from the resulting ecological and economic interactions.  AGFORWARD (AGroFORestry that Will Advance Rural Development) is a four-year project, developed by 23 organisations at the forefront of agroforestry research, practice and promotion in Europe, with the goal of promoting appropriate agroforestry practices that advance sustainable rural development. The project will i) increase our understanding of existing, and new extensive and intensive agroforestry systems in Europe; ii) identify, develop and demonstrate innovations to improve the ecosystem service benefits and viability of agroforestry systems in Europe using participatory research, iii) develop better adapted designs and practices for the different soil and climatic conditions of Europe, and iv) promote the wide adoption of sustainable agroforestry systems.Successful and sustainable agroforestry practices are best developed by farmers and land owners working in partnership with researchers, extension staff, and other rural businesses. AGFORWARD will facilitate 33 participative agroforestry research and development stakeholder groups to improve the resilience of i) existing agroforestry systems of high nature and cultural value such as the dehesa and montado; and ii) olive, traditional orchard, and other high value tree systems, and the sustainability of iii) arable and iv) livestock systems with the integration of trees. Using existing bio-economic models, AGFORWARD will evaluate and adapt the innovations to improve the delivery of positive ecosystem services and business profitability at farm- and landscape-scales across Europe.  By using and developing existing European fora,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'SPARKLE - Training Europe's Future Photonics Research Leaders'.

assistant: **Innovation**

Photonics impacts our everyday lives, from the screens that drive our mobile phones, to the fibre optic based communications network that underpins the modern internet, to light based diagnostics systems that identify diseases. It also represents an enormous worldwide sector that is growing twice as fast as the global GDP and expected to reach €615 billion in 2020. Europe is at the heart of this industry with a market that has grown by over 62% over the last 10 years, investing about €10 billion per year in innovation through its 5,000 photonics companies that directly employ over 300,000 with a global market share of 15.5%, second only to China. SPARKLE is an innovative photonics focused intersectoral training, career development and mobility fellowship programme that will be open to experienced researchers of any nationality, resident anywhere in the world, seeking a prestigious career development path in the field of photonics research and innovation. These future leaders with combined skills in scientific excellence, product develop and manufacturing, will be equipped to compete at the highest levels and will ensure that Europe secures a significant proportion of the projected 10,000 new jobs per year that will be created by the photonics industry. The SPARKLE programme will offer 27 two-year fellowships.Objectives: 1. An advanced training programme in a cutting-edge research environment to train the future cohort of world leaders in the field of photonics, highly employable both in academia and industry.2. Strengthen and raise the excellence and impact of Europe’s photonics research and manufacturing activities, and ensure that Europe continues to compete with the US and China through the transition of leading edge science into market leading products.3. Address th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of cellular proteins involved in uptake and cross-presentation of pathogen-derived proteins by professional antigen presenting cells' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The proposer is an accomplished investigator who has spent six years in the US and wishes to return to her home country. Over the years, the research of the proposer has focused on the MHC-I antigen-processing pathway in infected cells and dendritic cells (DC) and on CD8 T cell priming. The main objective of this proposal is to obtain funding to help the proposer to return to and reintegrate into her home country and to establish a research group there.The research project: The induction of protective CD 8 T-cell responses against intracellular pathogens requires that DC internalise pathogen-derived proteins (antigens) and process these into small peptides. Such peptides, presented by MHC-I molecules on the DC surface, will activate antigen-specific CD8 T-cells to eliminate infected cells. So far, the cellular mechanisms involved in antigen uptake and processing for cross-presentation" by uninfected DC remain poorly understood.This project aims to identify proteins that play a role i n antigen cross-presentation. We will use a lentivirus-expressed small interfering (si)RNA library that targets 34.000 mouse genes to silence the expression of single genes in hematopoietic stem cells that will be differentiated into DC. These DC will be tested for their capacity to cross-present antigens and DC that lack cross-presenting activity will be sorted using multi-colour flow-cytometry. siRNAs expressed in the purified DC will be identified by micro-array analysis. The function of the so identified gene products will be analysed using transfectant cell lines that express siRNA constructs of interest.We expect to identify different categories of proteins that are essential for antigen presentation on DC and, thereby, to unravel the MHC-I antigen-processing pathway that operates in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Better births initiative' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

A previous Concerted Action EU grant (  Tropical Medicine on Trial", contract ICI8CT96-0086) included action research projects around evidence-based medicine. One topic area that was developed concerned obstetric practice, particularly in relation to painful and unnecessary procedures for which no good evidence of benefit existed. Collectively, we conducted action-research projects in China, Zimbabwe, and South Africa, with a project in Chile currently underway. At the same time, we have drafted the "Better Births Initiative", to help draw this work together. We are applying now for funds to allow researchers to exchange result sat a meeting in South Africa, and to allow dissemination, feedback and intervention research planning in China."