RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Bioengineering lung tissue using extracellular matrix based 3D bioprinting'.

assistant: **Objectives**

Chronic lung diseases are increasing in prevalence with over 65 million patients worldwide. Lung transplantation remains the only potential option at end-stage disease. Around 4000 patients receive lung transplants annually with more awaiting transplantation, including 1000 patients in Europe. New options to increase available tissue for lung transplantation are desperately needed.An exciting new research area focuses on generating lung tissue ex vivo using bioengineering approaches. Scaffolds can be generated from synthetic or biologically-derived (acellular) materials, seeded with cells and grown in a bioreactor prior to transplantation. Ideally, scaffolds would be seeded with cells derived from the transplant recipient, thus obviating the need for long-term immunosuppression. However, functional regeneration has yet to be achieved. New advances in 3D printing and 3D bioprinting (when cells are printed) indicate that this once thought of science-fiction concept might finally be mature enough for complex tissues, including lung. 3D bioprinting addresses a number of concerns identified in previous approaches, such as a) patient heterogeneity in acellular human scaffolds, b) anatomical differences in xenogeneic sources, c) lack of biological cues on synthetic materials and d) difficulty in manufacturing the complex lung architecture. 3D bioprinting could be a reproducible, scalable, and controllable approach for generating functional lung tissue.The aim of this proposal is to use custom 3D bioprinters to generate constructs mimicking lung tissue using an innovative approach combining primary cells, the engineering reproducibility of synthetic materials, and the biologically conductive properties of acellular lung (hybrid). We will 3D bioprint hybrid murine and human lung
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A device enabling quantification of molecular and nanoparticle diffusion within thin solvated films' (DIFFUSION).

assistant: **Innovation**

The objective of the DIFFUSION project is to develop an easy-to-use device to analyse diffusion processes within thin solvated films. This new analytical tool will overcome a current bottleneck in the development of functional coatings for a wide range of applications, from fundamental research in biophysics and microbiology to real-life applications in biomaterials and paints.Driven by analytical needs during the ERC Starting Grant project JELLY my team and I conceived the DIFFUSION technology. The technology has the potential to enhance research and development in industry and academia – in material sciences and engineering, physics, chemistry and biology – wherever functional thin films/coatings are developed or used. It enables the analysis of molecular and nanoparticle diffusion within thin solvated films, thus providing new information that is instrumental to the development and quality control of films/coatings with superior performance and new functions yet has so far been challenging to assess. The technology is conceived as a modular add-on device that enhances the capabilities of the users' existing existing optical microscopy setups. An initial market analysis has already shown that there is broad interest in the method in academia and industry, and that the solution we aim to offer would be attractive. This Proof of Concept grant is required to develop a second-generation prototype to demonstrate that a cost-effective and easy-to-use device is feasible, to demonstrate its added value with selected application examples covering target research and development areas, and to develop a commercialisation plan including the identification of an industrial partner that is ready to build on the second-generation prototype and rapidly move a device into production a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Going from Phenomenal to Access Consciousness: Neurobehavioural correlates of visual consciousness development and its underlying cognitive procesess.' under Horizon 2020.

assistant: **Concept**

The concept of visual consciousness is notoriously hard to define. According to Block (1996),visual consciousness, rather than being unitary, is an hybrid theoretical construct that includes at least two discernible concepts: Phenomenal or P-consciousness, which represents the experiential properties of our perceptions, and Access or A-consciousness, which refers to the availability of part of the visual information for use in reasoning and rationally driven action.Intriguingly, according to Lamme (2003), the two types of consciousness can be linked to different stages of visual information processing. Specifically, P-consciousness is related to the iconic memory content of the original visual experience, while A-consciousness is associated with the working memory content of a “survived” piece of the original experience, after different processing stages. The route from P- to A- consciousness (PtoACons) involves several cognitive processes, such as attention, memory, decision-making and metacognition, which are intermingled and spatiotemporally overlaped. This route emerges from the activity of multiple neurons interconnected by local visual and global fronto-parietal brain networks. Despite that in the last years has been done a significant progress on the knowledge of the brain circuits of visual consciousness, its precise functional organization and neural dynamics are still largely unknown.The present project aims to scan the spatiotemporal evolution of visual consciousness, by combining psychophysical measures, MEG recordings and patients’ studies. More concretely, it attempts to dissociate the behavioural responses and neuro-functional correlates of P- and A-consciousness and to elucidate how several attentional mechanisms and memory processes are involved in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Healthy feed for safety - Dissemination of research results of EC funded research on feed quality'.

assistant: **Objectives**

The Feed-SEG project will bring together experts form academia, industry and decision-makers to exchange know-how and to discuss and prepare for the future policy development but also to identify the most promising research fields in feed safety. The proposed Feed-SEG SSA is based on an initiative to network the currently running EU-projects REPLACE, PIG for HEALTH and SAFEWASTES, which are all focusing on research to improve and to develop healthy feed for the safety of livestock and humans. The objective is to bridge the research results of these and other existing EU projects with the identification of new research topics, policies and tendencies in the future. The issue of how to find effective alternatives to address the removal from routine use of antimicrobials in animal feeds has been addressed by a number of research projects which responsible experts behind will be integrated during the project. The 24-months project activities include to promote and facilitate the dissemination, exploitation and transfer of current EC ??? funded research project results, it will contribute to objectives of a common policy development and will prepare for future community RTD activities, and will futher integrate researchers and experts from the New Member States (NMS) and Associated Candidate Countries (ACC). Feed-SEG is a re-submission of a proposal submitted in the last call (FP6-2004-FOOD-3-C) which was evaluated as being ???exactly and highly relevant??? and passed all tresholds, but was not retained for funding because of budgetary restriction. In accordance to the overall comments made in the Evaluation Summary Report, changes have been adopted in the new proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Health care in chronic non-fatal disease by the example of inflammatory bowel disease' in the context of a Fifth Framework call.

assistant: **Objectives**

The present study concentrates on health care in the field of gastroenterology in which an important chronic non- fatal disease will undergo synchronous, uniform, and (near) total analysis of all-important aspects related to long-term disease outcome. In addition, this effort will be made in a European population based patient group covering the whole geographic width of the continent. The effort will be facilitated by the fact that the patient cohort is already well defined by previous studies. Our hypothesis is that chronic non-fatal diseases have an evolving course in time. Natural course of disease" does not exist any more, as changing therapeutic, social, and environmental factors continuously influence the outcome. The proposed study will serve as an example to the medical and paramedical community, showing periodical updating to be necessary for every chronic non-fatal Condition. This study will deliver simultaneous scientific evidence of all aspects influencing disease outcome for both the single patient and the community. Based on this evidence a convincing model will be contemplated forth European Community to project health care planning for both IBD and other chronic non-tat diseases"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fe Fuel Particle Design for Renewable Energy Storage' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The global transition to renewable energy is one of the most critical challenges of our time. Iron powder has been proposed as a new sustainable energy carrier to replace fossil fuels in energy management. During its oxidation, heat is released and can be stored by reducing the resulting iron oxide using renewable energy. However, significant challenges remain for Fe fuel, such as transport and storage safety, ignition efficiency, micro-explosions, particle inflation, nanoparticle emissions, and particle agglomeration. To date, these issues have only been addressed by adjusting extrinsic combustion parameters like pressure, temperature, and gas composition, an approach that falls short of solving the fundamental limitations. FeFES offers a groundbreaking solution by focusing on controlling the microstructure, morphology, and chemistry of Fe particles. By combining combustion engineering with materials science, FeFES will design Fe particles specifically tailored for sustainable energy storage. Their microstructure will be optimized to meet the needs of the Fe fuel cycle and naturally regenerate. Using novel experimental approaches, including in situ X-ray synchrotron studies, FeFES will quantify the microstructural evolution of burning iron fuel for the first time. These experimental insights will be paired with advanced phase field models to comprehensively understand the impact of the particle design on its combustion behavior. The breakthroughs from FeFES will have wide-reaching benefits, including accelerating the development of renewable energy production through efficient energy storage and transport, expanding the use of metal fuels beyond pure metals, and advancing our understanding of liquid-state metal oxidation. This project holds the potential to reshape ene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Automatic extraction of keywords for biological sequences' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The increasing rate at which biological sequences arrive at public databases makes difficult high quality manual annotation. We propose an automatic method for finding keywords to descrive novel sequences; the method is based on the distribution of words in MEDLINE abstracts related to the sequence. The method will be used by database annotators at the European Bioinformatics Institute (Cambridge, UK). We will also provide a World Wide Web (WWW) server for European molecular biologists which gives 'intelligent' links between sequence and related MEDLINE articles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Defining and validating gut health criteria in young pigs, based on digestive physiology, microbiology and mucosal immunology investigations for testing alternative strategies to in-feed antibiotics' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The EU expects health degradation of pigs at weaning in intensive production systems after the recent ban on in-feed antibiotics and metals. Many alternatives with claimed effectiveness have invaded the market prior to being fully evaluated. Our objective is to provide scientific basis for understanding the functional disturbances of the gut, which favour enteric infections. We propose to use the disturbed weaned pig as a model for defining the major criteria for gut health. We will measure the changes occurring in gut physiology and digestion, mussel integrity and function, bacterial populations, and intestinal immunity, using the most modern techniques. The ability of selected novel feed additives and rearing strategies to maintain or restore gut health will be assessed in large pig trials using the most pertinent defined health criteria. This will contribute to set up a uniform approach to testing alternatives at the EU level and will assist socio-economical partners in making well-informed decisions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Investigation of dynamical proccesses affecting the vertical exchange of pollutants in the convective boundary layer' (1994-1998).

assistant: **Innovation**

The scientific aim of the proposed work is to study dynamical processes within the atmospheric boundary layer (ABL) that affect the vertical exchange of heat, momentum, water vapour and pollutants between the underlying surface and the free atmosphere. The studies will combine the analysis and interpretation of sodar measurements with the use of simple numerical models. In detail, the following issues will be investigated: - determination of the ABL-height and of the depth and internal structure of the entrainment zone (EZ) at the top of a convective boundary layer / realization of different algorithms for the estimation of the EZ-thickness from sodar data and comparison with results from radiosonde/tethersonde observations, - identification of data processing procedures to derive the relevant input parameters for the coupled mixed- layer/entrainment-zone model of Batchvarova and Gryning (1994) from sodar data, - validation of the model proposed by Gryning and Batchvarova (1994) using sodar data - investigation of wind shear and wave processes at the convective boundary layer top and their contribution to the entrainment process. Taking into account the significance of entrainment zone processes to the vertical exchange of energy and matter between the polluted ABL and the free troposphere, the elaboration of operational methods to estimate basic mixed layer and entrainment zone parameters is considered to be of high practical relevance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New routine DNA detection method using cycling probe reaction and particles couting' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Very low levels detections of viruses are today managed through either the well known PCR and nested PCR or the LCR amplification processes. These are very sensitive techniques allow recognition of just a few viral or pro-viral DNA copies by sample. Those techniques mainly used in research laboratories and university clinical laboratories or associated are very heavy to perfom requiring skilled people and expensive infrastructures. Our experience in DNA detection and quantification and the very promising DNA diagnostic market led us to find more convenient and alternative methods to the PCR and LCR in order to spread out DNA detection to bigger quantities of clinical laboratories. The objectives of this project will be to set up and adjust a full automatic machine for routine quantification and detection of nucleic acid sequences for molecular diagnostic of many pathogens, of genetic diseases or of the recognition of specific sequences in research laboratories by using the Cycling Probe Reaction" combined to a technology called "the Particles Counting Technology" (CPR-PCT). "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sensefinity Social Machines', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Sensefinity wants to become the Enabler of the IoT (Internet of Things) for the Masses. This is only possible through the development of a disruptive and innovative project in IoT that will allow to easily implement IoT projects with low CAPEX and OPEX investments.sensefinity will offer an off-the-shelf sensor-platform integrated into a Cloud and SaaS (Software as a Service) to provide specialised applications for business; by providing pre-integrated devices with SaaS software prepared for each of them, i.e. Consumer, Retail, Building, Medical, Energy, Transport and Industry, the IoT can become commonplace, a commodity, and, thus be accessible to any company in any sector of activity. In this context, it will be the first time that IoT projects will be implemented in companies from zero to M2M in no time. Nowadays, only large corporations have the means to invest to gather the data generated by their physical assets. However, these solutions are based on expensive bespoke projects and have a long implementation time, and due to their custom nature are expensive to replicate. This constitutes a barrier for SMEs which cannot afford the price of these bespoke and costly projects. The proposed innovation project will result in an off-the-shelf solution to obtain business profit from the IoT concept and the information acquired by physical assets right after unpacking.These features will fulfil SME's needs with regard to IoT, and in all business verticals. Large Corporations and multinationals will also constitute a considerable demand-market.sensefinity consider essential to develop a Feasibility Study that will explore in detail the markets involved, state-of-the-art and suppliers, demand market and vertical applications, sensor types and suppliers, the competition; the b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fast, easy diagnostics for personalised phage therapy' (Phagediag).

assistant: **Concept**

Personalised phage therapy using magistral preparations of phages is among the most promising solutions to fight antimicrobial resistant infections, but this approach requires a rapid diagnostic that identifies the pathogen(s) involved in the infection and the phages active on them. Vésale Bioscience has developed the “Phagogram”, the first automated in-vitro diagnostic tool that enables a fast determination of bacteriophages suitable for treating a particular bacterial infection. It consists of a basic test kit (a disposable well plate with reagents), a high-performance luminometer and a dedicated software that proposes the best matching phage cocktail to treat the patient. Compared to the current diagnostic methodologies, which take up to 4-7 days, the Phagogram compares the activity of up to 96 phages on a bacterial culture within 2-3 hours, making phage susceptibility testing accessible for hospital microbiology labs and enabling personalized therapy on a routine basis.


**Keywords:** Bacteriophages,AMR,phagogram,nosocomial infections,antimicrobial resistance,phage therapy,phages,antimicrobial multiresistant infections