RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Steering role of infochemicals for food function and structure' (SNIFFS).

assistant: **Innovation**

The freshwater environment is influenced by antropogenic influences much more directly than the marine environment, which has lead to major problems with water quality in these systems. Earlier efforts to improve water quality via fish stock management (biomanipulation) in order to reduce the internal nutrient loadings of systems initially seemed promising. However, the lack of proper knowledge and understanding of the trophic interactions in freshwater systems has lead to costly failures. One possible reason for this is, that in food chain- and ecosystem studies, the attention has thus far been focused almost exclusively on the transfer of matter and energy between the different trophic levels, whereas the effect of information flow (by infochemicals) on the matter/energy flow has been largely ignored. The coupling of the flows of information and matter is the main objective of this project. Hence, the objectives are: 1) To describe quantitatively the matter/energy flow in a simple tritrophic food chain of two contrasting aquatic ecosystems in the catchment of the River Rhine; 2) to isolate and identify infochemicals affecting the structure and functioning of tritrophic food chains; 3) to measure the concentration dependence of individual and population responses to infochemicals in laboratory systems, and to measure the effects on the outcome of competition for resources; 4) to evaluate in model studies, employing individual-based models, the effects of different infochemicals on the transfer of matter and energy in the tritrophic food chain of two contrasting ecosystems on a larger temporal and spatial scale; and, 5) to propose guidelines for an improved integral water management. Part A describes the idea, current state of the art and how the objectives comply with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Embedded learning and optimization for the next generation of smart industrial control systems' (ELO-X), addressing dissemination and exploitation.

assistant: **Impact**

Thanks to the increasing capabilities of digital technologies, the next generation of industrial control systems are expected to learn from streams of data and to take optimal decisions in real-time, leading to increased performance, safety, energy efficiency, and ultimately value creation.Numerical optimization is at the very core of both learning and decision-making, and machine learning algorithms and artificial intelligence raise huge worldwide research interest, often using cloud computing and large data centers for their optimization computations.However, in order to bring learning- and optimization-based automated decision-making into smart industrial control systems (SICS), two important bottlenecks have to be overcome: (1) computational resources on industrial control systems are locally embedded and limited, and (2) industrial control applications require reliable algorithms, with interpretable and verifiable behavior. Both requirements partially stem from safety aspects, which are crucial in applications where a single computation error can cause high economic and environmental cost or even damage to people.Pushing the performance boundary of SICS to leverage advanced digital technologies will therefore involve both fundamental new research questions and technological solutions, calling for a new set of advanced methods for embedded learning- and optimization-based control algorithms. Through its 15 PhD students hosted and seconded at 11 top European research centers (6 academic, 5 industrial) and 4 partner organizations in the US, Japan and China, ELO-X will address the timely and pressing need for highly qualified and competent researchers who will develop embedded learning- and optimization-based control methodologies for SICS, thus enabling new and possib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Highly Integrated Nanoscale Robots for Targeted Delivery to the Central Nervous System' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Over the past two decades researchers have been working to create synthetic small-scale machines ranging from molecular entities or miniaturized structures, to more complex assemblies of micro- and nanomaterials. These machines are able to navigate in complex environments by harvesting fuel from the surrounding media or from external power sources. One of the most sought-after applications for these miniaturized machines is to perform minimally invasive interventions, in which these devices will ultimately reduce risk, cost, and discomfort compared to conventional interventions. This has driven researchers to produce a myriad of small-scale robots loaded with therapeutic cargo. While recent research has demonstrated the potential of these devices in animal models, a number of challenges remain in moving small-scale robots into the operating theatre. Here, we propose highly integrated nanorobots capable of realizing several functions on-demand by capitalizing on recent developments in small-scale robotics, multiferroics, supramolecular chemistry, and gated materials. These nanorobots will integrate a porous inorganic active chassis made of a piezoelectric or a magnetoelectric multiferroic that will host therapeutic agents, with redox or electroresponsive supramolecular gates that will control the release of payloads. We will demonstrate for the first time that redox- and electroresponsive supramolecular machinery grafted onto the surface of piezoelectric or multiferroic platforms can be remotely controlled by means of a piezoelectrochemical potential triggered by acoustic and magnetic fields. The ultimate goal of this research consists of creating smart multifunctional nanorobots, which will act on affected sites of the central nervous system by delivering therapeutic ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemical mutagenesis: a powerful tool for the creation of a library of nanobodies' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Finding a non-aggressive treatment against Cancer is one of the most important challenges that medicine has nowadays. Immunotherapy has emerged as one of the best options to overcome the current problems of chemotherapy. By the use of monoclonal antibodies (mAb), immunotherapy is able to block regulatory checkpoints and, therefore, the immune response against tumoral cells could be modulated. Trastuzumab, pembrolizumab and nivolumab are some of the mAb approved by the Food and Drug Administration (FDA) for their use against several cancers. Trastuzumab recognizes the overexpressed protein HER2 in breast cancer, whereas the pembrolizumab and the nivolumab recognize the Programmed Cell Death-1 (PD-1) receptor and are used in several cancers such as refractory melanoma.However, there are reported important issues concerning cancer resistance to these mAb, thus, modifying their characteristics became necessary. Unlike it happens with small molecules, there are several limitations to functionalize an antibody to improve its characteristics. In this context, chemical mutagenesis turns into a powerful tool because it allows the modification of an antibody directly with highly specific chemical reactions, and achieve changes onto its structure that would not be possible by using other techniques such as protein engineering and genetic encoding.In this proposal I envision the use of nanobodies able to recognize HER-2 protein and PD-1 receptor in order to improve their affinity to their targets by chemical mutagenesis via alanyl radical. The success of this project would provide solutions to the cancer resistance to current immunotherapy.


**Keywords:** Chemical mutagenesis, nanobody, site-selective protein modification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural and thermophysical properties of quantum fluids  adsorbed on nanostructured surfaces' in the context of a Horizon 2020 call.

assistant: **Objectives**

The general aim of this project is the development of advanced computational models that enable affordable yet accurate quantum mechanical calculations of the structure and thermophysical properties of atomic and molecular fluids adsorbed on nanostructured surfaces.The proposed method is based on the liquid density functional theory (to treat the nuclear quantum dynamics) with the first principle evaluation of the interaction forces employing state-of-the-art electronic structure methods. These models will be subsequently applied to the computational investigation of macroscopic quantum effects on the adsorption isotherms, the isotopic selectivity on adsorption, particle diffusion, etc, of helium and hydrogen fluids adsorbed in nanoporous materials. We will focus on the characterization (via computational screening) of the influence of the structural and electronic properties (e.g., the size and geometry of the pores, the specific surface area, the topology of the electronic states) on the capacities of nanomaterials for hydrogen storage and isotope separation via quantum sieving. The density functional simulations will provide a realistic representation of the nuclear motion underlying storage and sieving phenomena in the target nanomaterials (e.g., metal- and covalent-organic frameworks), and accurate estimations of strutural and thermodynamics properties of the adsorbed fluid, in situations where the computational cost of the standard numerical schemes becomes prohibitive. The insight provided by these calculations can be used to guide the experimental efforts on the investigation of the target systems, and on their applicability in the design of more efficient nanodevices. Consequently, they may lead to significant savings of energy and of natural resources, associa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-Material 3D-Printing for Nano-Engineered Microbots' (PRINTBOT) targeting Horizon Europe.

assistant: **Abstract**

Microbots have the potential to revolutionize modern medicine by performing precise operations at microscopic scales, enabling safer and more efficient diagnostic and therapeutic solutions. However, breakthrough innovations required to significantly enhance patient care are currently hindered by challenges in manufacturing at the lowest microscale, particularly limitations in material versatility, nanoscale resolution, and design flexibility. These constraints result in inefficient propulsion and restricted functional capabilities in current microbots. The PRINTBOT project aims to overcome these challenges by developing sub-10 µm microbots with highly efficient propulsion systems and advanced functionalities. Two propulsion concepts will be explored for operation in liquid environments: (1) artificial ciliary microbots – 20 times smaller than current models, and (2) magnetic helical swimmers with novel designs for efficient locomotion.Beyond propulsion, PRINTBOT will introduce innovative functionalities, such as controlled cargo mechanisms and heating antennas that can be modularly attached to microbots. These features will allow the microbots to selectively capture / transport / release particles, and carry out localized hyperthermia treatments, such as targeted tumor cell inhibition.The project will also create the ImmunoBot, an artificial immune cell designed to capture and neutralize pathogens through targeted heating, mimicking the body´s natural defense mechanisms.These innovations will be enabled by PRINTBOT´s pioneering work in multi-material 3D-nanoprinting, allowing a seamless, modular integration of materials with various functionalities within a single 3D-structure, establishing new benchmarks in nanoscale additive manufacturing.PRINTBOT´s outcomes are expec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Powder Metallurgy Euro Summer Schools' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Powder metallurgy (PM) is a term, which encompasses all aspects of the science and technology involved in the manufacture of useful products from metal and alloy powders and their applications in engineering. The industry in the EU employs around 40,000 people, has a combined market of about 6 billion and is experiencing above average growth in all of its sectors. PM is a strongly interdisciplinary topic. It is also among the lowest energy consuming manufacturing methods and additionally offers high material utilisation. PM technology and its scientific understanding is evolving rapidly worldwide, but in contrast in particular to USA, industry in EU has been slow to take advantage of the potential gains. With the exception of those involved directly, design engineers, materials engineers and end-users are often inadequately informed and interactions between those groups are not well developed. This is despite the presence in the EU of industrial corporations, research institutions and academic schools of world renown. The PM summer schools propose to make advanced expertise available to young engineers from a variety of backgrounds in addition to those currently engaged in PM.General aims are: a) to provide in a concentrated form the basic interdisciplinary sciences to be applied to PM, b) to provide an appreciation of current technology, its advantages and limitations c) to signpost the directions of scientific and technological advance, d) to provide gateways to sources of expertise, information and help within Europe, e) to provide a meeting point for young engineers from diverse backgrounds to exchange ideas amongst themselves and with leading figures in the field, f) by drawing participants from all countries of the EU and Associated States, to assist in the devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Contribution of planar cell polarity to dorsal closure in drosophila'.

assistant: **Concept**

Dorsal closure is a well studied morphogenetic process of Drosophilae embryo genesis during which the lateral epidennis moves dorsally, driven in part by dynamic acting protrusions of a specialised population of epidermal cells, the leading edge (LE) cells. Recently, a molecular map of the epidermal cells has revealed that LE cells are polarised in the plane of the epithelium. This polarisation reflects planar cell polarity (PCP) and genetic studies have suggested an involvement of PCP genes in the organisation and dynamics of the cytoskeleton in the LE cells during dorsal closure. Here I propose to study this involvement, focussing on the requirements and interactions between the PCP genes frizzled, dishevelled, flamingo and strabismus and their products. I shall do this by using studies of intracellular protein localisation to refine the molecular map of these proteins in LE cells and analyse their functional relationships through genetic analysis. I will also probe the molecular basis of interactions between these proteins by studying the contribution of their different domains to the generation of asymmetry and to their likely mutually dependent localisation. Finally, in an attempt to identify new components involved in the PCP process I will analyse complexes contributing to polarisation of LE cells using proteomic approaches.The combination of these experiments will provide a mechanical explanation for the establishment of polarity in the LE cells during dorsal closure that is likely to be relevant to other situations involving PCP.In addition it should provide insights into how PCP is transformed into acting dynamics. The study of intracellular proteins localisation in LE cells will be achieved by confocal imaging, either on fixed embryos stained with antibodies,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Secretariat for the International Consortium for Personalised Medicine (ICPerMed)' under Horizon 2020.

assistant: **Concept**

The potential of personalised medicine (PM) is to improve prevention, diagnosis and treatment of diseases by taking into account individuals' genotypes and phenotypes as well as other biomedical, life style and environmental data. However, with some exceptions in cancer and rare diseases, PM has not yet arrived in clinical practice due to fragmentation, undefined legal and regulatory frameworks and its unclear economic value. To overcome these hurdles, ICPerMed was founded to initiate and support communication and exchange on PM research, funding and implementation. ICPerMed provides a platform to identify the requirements for a suitable framework in terms of infrastructures, resources and regulatory procedures to foster the development and implementation of PM. The ICPerMed Secretariat will continue to substantially contribute to the success of ICPerMed by efficiently coordinating all consortium activities. This includes supporting the ICPerMed governance and working groups as well as organising ICPerMed internal meetings and thematic events.  A further important task of the ICPerMed Secretariat will be the implementation of an effective dissemination plan and the assistance in the development of a sustainability strategy. By monitoring ongoing research funding activities and collecting “Best Practice Examples”, the secretariat will provide the basis for evidence informed allocation of research funding and regulatory framework and standard development. The ICPerMed Secretariat will guide the dialogue with relevant stakeholders and initiatives. It will support training measures in PM in order to facilitate implementation of PM into practice. The organisational and logistical support of a secretariat will maximise the unique and long-term impact of ICPerMed by strengthen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'An in-vivo RNAi approach to identify and evaluate suppressors of anti-tumor T cell immunity'.

assistant: **Objectives**

The immune system plays a major role in safeguarding us from cancer. Tumor progression is closely linked to functional suppression of T cell responses, and strategies to reactivate tumor-specific CD8+ T cells hold great promise for cancer therapy, as evidenced by recent clinical breakthroughs. However, the further exploration of such therapies is hampered by our incomplete understanding of key genes and pathways involved in suppression of anti-tumor T cell immunity. Here, we propose an innovative approach combining three well-established experimental systems - genetically engineered mouse models of human cancer, T cell receptor/cognate antigen transgenic mice, and advanced in-vivo RNAi screening technologies - to systematically identify and functionally evaluate genes involved in this process. Specifically, we will establish an experimentally scalable in-vivo RNAi system to investigate genes modulating interactions between OT-I transgenic T cells and cOVA expressing cancer models, and use it in a multiplex in-vivo RNAi screen to survey a focused shRNA library targeting ~400 candidate T cell suppressor genes. Using this innovative screening approach and a sequential functional validation strategy, we seek to identify and functionally study new factors involved in the suppression of anti-tumor T cell immunity, ultimately to guide the development of more effective targeted cancer therapies.