RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cell fusion-mediated reprogramming as neuronal rescue mechanism in Parkinson’s disease', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Dopamine (DA) cell replacement therapy in Parkinson’s disease (PD) can be achieved using human fetal mesencephalic tissue, however, limited tissue availability has hindered further developments. Alternatively, replacement of damaged DA neurons with their fusion with adult stem cells after bone marrow stem cells (BMSCs) transplantation is an attractive possible route to the restoration of neurological functions in PD. Fusion of BMSCs with somatic cells may account for some of the findings of BMSCs-neuronal differentiation. In addition, the periodic activation of the Wnt/β-catenin signalling in embryonic stem cells remarkably enhances cell fusion-mediated reprogramming of different somatic cells in vitro. Thus, in this research proposal, the main goal is to determine whether cell fusion-mediated reprogramming it occurs in vivo. Our hypothesis is that activation of the Wnt/β-catenin pathway is crucial to enhance reprogramming of fused cells and may rescue injured DA neuron cells in PD. Thereby, we will transplant perturbed (Wnt-activated) hematopoietic stem cells (HSCs) into mice suffering from experimental PD. Then, we will determine whether Wnt/β-catenin signalling controls and enhances in vivo reprogramming of hybrids formed in response to the neurodegenerative process. Furthermore, we will verify if Wnt-mediated reprogramming after HSCs fusion can repair the injured tissue. Accordingly, genetic approaches will be used to evaluate cell fusion and reprogramming events in the tissues analyzed. Short- and long-term regeneration will be also studied. In conclusion, cell fusion-mediated reprogramming mechanism could lead to the development of radical new therapy for Parkinson’s disease that currently lack effective treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Non-Perturbative Path Integrals for Quantum Gravity' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

One of the biggest gaps in our understanding of the physical world is the missing fundamental theory of gravity. Einstein and apos general relativity is a classical theory, but we know our world is quantum. So what is quantum gravity? Since, as Einstein taught us, any theory for gravity is also a theory of the geometry of space and time, this is an extremely challenging question - answering it will completely change our understanding of what space and time really are. This makes it also into a great intellectual adventure: it needs radically new ideas, new mathematics, and it will profoundly change physics. And what is more, in the not too distant future, effects of quantum gravity may be experimentally detectable!   Path integrals are a powerful and time honoured approach to quantum field theory. One can start working from an action, i.e. essentially just from symmetry properties of the theory in question, and in principle a reasonable classical limit is assured. All of that makes them very attractive for quantum gravity, too.   Of particular importance for us are three such approaches to quantum gravity: Loop Quantum Gravity, Spin Foam Models, and Causal Dynamical Triangulations. They all are promising approaches, but they also all have issues that are not yet well understood. Very important for us is that they are complementary in many ways. Relating the approaches to each other will shed new light on many old problems. Lessons learned in one can be applied to the other. And techniques developed for one can be transferred between the approaches.  In particular we propose to study the following issues:  - Divergence of spin foam amplitudes, and the relation between Euclidean and Lorentzian theory  - Mathematical foundations and diffeomorphism invariance of Causal Dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ground breaking 3D cell culture platform to eliminate animal testing in pharmaceuticals', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The use of in-vitro testing (in simulated environment) is the future of drug development, cancer research and medical research in general since it overcomes the practical and ethical issues associated with human and animal experimentation. However, as much as 85% of early clinical trials currently fail despite successful preclinical in-vitro testing; in the case of clinical cancer trials it is less than 8%. The main reason for such low success rates is that currently used 2D cells do not behave the same in living bodies as in cultures. As a consequence, animal testing continues to be widespread despite the associated cost and strong ethical concerns it raises. This is also extremely costly in time and resources which raise consumer prices for life-saving medications.InoCure is addressing this problem with the DifMATRIX - a unique 3D scaffolding platform with drug delivery embedded system, for cell culture used in molecular biology and tissue engineering. DifMATRIX enables to simulate natural cell phenotype (in vivo) in the in-vitro environment. It redefines in-vitro preclinical testing standards, significantly improving preclinical-to-clinical translation efficiency and provide an alternative to animal testing models. The predicted impact of the project is to eliminate the animal testing phase from the drug development process.The project is well aligned with new trends in cell and tissue culture supplier market. Globally, this market is witnessing significant growth due to increasing demand for biopharmaceuticals and increasing R&D in this field. The global cell/tissue engineering supplies market is expected to reach $28 billion in 2020. The market demand for DifMATRIX has been confirmed by customers currently using our passive InoMATRIX product, and by the letters of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Mathematical modelling of in vivo cell dynamics in germinal centres'.

assistant: **Concept**

Today's modeling approaches in Biology and Medicine are widely based on unproven hypotheses, and biological data concerning cell behavior in vivo are largely descriptive. This inhibits both the merging process of theoretical and experimental Biology and the understanding of biological systems with medical impact. The aim of this project is to overcome this problem by developing innovative simulation approaches adapted to solving complex biological questions.The simulations are constructed to bridge the gap between single cell behavior and emerging properties such as highly organized supra-cellular networks with optimized functionality, and gain predictive power by relying on detailed cell mechanics data. The method can be transferred to numerous applications related to large numbers of interacting visco-elastic objects including industrial applications. The germinal centre as a central part of adaptive immunity is such a dynamic and complex system. It is aimed to develop a comprehensive germinal centre theory from the first data of in vivo cell dynamics in germinal centers.Compared to classical germinal centre research the combination of high-end simulations with intravital two-photon imaging and advanced immunological techniques as proposed here will allow a phase transition in Immunology. The functional understanding of the dynamics of adaptive immunity will only be possible by exploiting the synergies of mathematical and experimental approaches. The novel method will be used to make predictive simulations of cell dynamics in immunological supra-cellular networks and to test a large number of experimental approaches in silico.Thus, animal model experiments could be designed more effectively, avoiding unnecessary experiments. The fruits of this project will not only be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis and self-assembly of Ferritin-based novel Biohybrid Nanoparticles' (SYSAFEBION).

assistant: **Innovation**

The aim of the proposed research is to construct and study new amphiphilic architectures built from the ferritin protein cage as a hydrophilic headgroup and a single synthetic polymer as the hydrophobic tail.These so-called giant amphiphiles have been pre pared before in the host group using single enzymes as the headgroup. However, the use of an intact protein cage is novel and no such structures have been reported in the literature.The aimed biohybrid polymer/protein architecture is even bigger than the giant amphiphiles studied so far, and the use of the ferritin cavity opens the way to introduce different functionalities (e.g. catalysts).Ferritin is particularly suited for this purpose as it is monodisperse and robust, and furthermore its demetallated analogue (apo-ferritin) can be used to encase a variety of inorganic potentially catalytic compounds, i.e. forming a self-assembling nanoreactor.The project consist of three work packages:- The first one will focus on the modification of the (apo-)ferritin with synthetic polymers. A single attachment point on the protein mantle will be introduced to which a polymer can be coupled or to use it as an initiator to grow a polymer from the nanometre sized bio-particle.- In work package 2 a detailed study of the self-assembling properties of the novel amphiphilic protein/polymer biohybrids will be carried out. The aggregation process will be studied by a variety of procedures such as spectroscopic studies, calorimetry, microscopy and scattering techniques.- In the final work package the potential application of the apo-ferritin protein cage as a nanoreactor will be investigated.Catalytic (inorganic) compounds can be introduced in this cavity, and assembling amphiphiles including different catalysts may eventually lead to a m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cellular Access to Broadband Services and Interactive Television', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Market potential for multi-channel interactive digital TV and broadband services is identified and rising. However, availability of low-cost, easily-installed last mile" end-user access is a serious barrier to exploitation. Low-power cellular wireless, coupled with in-band interactive return links, offers a potentially attractive solution.CABSINET intends to clarify the technical and commercial uncertainties surrounding this area. The main objectives are:to design, build and demonstrate a working interactive cellular TV architecture at 40 GHz, capable of the delivering both broadcast and ATM-derived multimedia servicesto compare the performance of this system with identified market requirementsto derive an exploitation plan for such services in the short/medium termto determine the potential for migration (e.g. to near-symmetric interactive broadband services)The project will liaise with the CRABS project in technical and commercial assessments.The output of the project will include:A proven and flexible Architecture for supporting interactive cellular TV and ATM-derived services, as well as possible future extended broadband servicesExtension of know-how in key fields such as protocols, MAC techniques, frequency / cell management, coding & modulationNew authoritative inputs to emerging DVB/DAVIC and telecommunications standardsReliable planning/simulation Tools so that roll-out of services can proceed smoothly and efficientlyExpected ImpactThe project aims to have identifiable impact and benefit for both industry and public:stimulation of new multimedia services, creating benefit for all parties involved in the value-chaindelivery of new services (e.g. entertainment, healthcare, education) to users either currently unable to receive fibre in the home, or for whom such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mechanistic Understanding of The Photoexcited Nitroarene-Mediated Olefin Ozonolysis'.

assistant: **Objectives**

Olefins are feedstocks readily available from petroleum and vegetable biomass with an integral role in the preparation of high-value materials. In particular, olefin ozonolysis used to introduce oxygen atoms and convert these molecules into a broad spectrum of synthetic intermediates like aldehydes, ketones and carboxylic acids.So far ozonolysis reactions mostly adopted by the bulk chemical industry which uses it on simple materials. The fine chemical sectors (pharmaceutical and agrochemical industries) do not use this reactivity mostly due to safety concerns in handling ozone.The Leonori group has recently demonstrated that photoexcited nitroarenes can be used as ozone surrogates for the oxidative cleavage of olefins. This project seeks to understand the key mechanistic factors that govern the reactivity so that generalization and application by the broad chemical community might be possible.The completion of such a timely and relevant mechanistic project at RWTH Aachen University will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance The Researchers future career following the training plan envisioned.


**Keywords:** photoexcited nitroarene, flash laser photolysis, mechanistic studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Social platform on research for families and family policies'.

assistant: **Concept**

The overall objective of the planned FAMILYPLATFORM is to elaborate a focussed research agenda that will address fundamental research issues and key policy questions for future research and family policies in Europe. Therefore, the platform will match three relevant perspectives: The perspective of the scientific community, the perspective of European families represented by important stakeholders such as family and children`s rights associations, and the perspective of policy makers and social partners. The FAMILYPLATFORM will focus on four areas: 1.Catching up with the current state of family research and elaboration of significant trends, differences between countries, gaps and methodological problems of existing research on families. Therefore a wide range of existential fields of family life and family policy will be taken into consideration. 2. A critical review of existing research from the perspective of a wide range of stakeholder representatives such as family associations, children`s right associations and policy makers and social partners, 3.Generating key policy questions for future European policy and research issues and tools focussed on “well being of families” as key concept in European policy, 4.Working out a research agenda with fundamental research issues, research areas and tasks of long-term studies, methodological tools based on step 1-3. The FAMILYPLATFORM offers a wide variety of forums: Conferences with debates to certain topics, workshops and future scenarios with defined tasks, focus groups for opinion formation, and discussion forums on the internet platform. In order to build a consensus, there will be special techniques of moderation. The FAMILYPLATFORM will involve a wide range of stakeholders from an early state of the project. The conso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '11th European Conference on Composite Materials (From Nano Interactions to Engineering Structures)' in the context of a Sixth Framework call.

assistant: **Objectives**

Over the last few years a new Renaissance in the development and application of composites is occurring. The use of composites in a variety of products from sporting goods to bridges and satellites is on the increase. The current research drive towards nanoscale phenomena has already given new impetus to the birth of new composites and to the improvement of existing products. The link between the nano-world and the emerging engineering structures remains one of the most important challenges to date. Europe is at the forefront of these developments. The ECCITI is the major European forum for the presentation of the latest results in a variety of research areas.Greece is not only an idyllic location for conferences but combines high quality of services at very competitive prices. In August 2004 the Olympic Games will be hosted in Greece. In preparation for such an important event there are numerous infrastructure projects in Greece that are being completed. Access to Aegean islands like Rhodes by sea or air will be easy and trouble-free. The conference venue offers excellent facilities for both high quality scientific interactions but also family leisure. We are confident that we can meet our target of a large number of delegates at a very competitive price and to make the ECCM-11 conference a memorable one for its scientific/ technical excellence but also for its overall organisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular mechanisms of epithelial plasticity and its involvement in carcinoma progression' (EPIPLASTCARCINOMA).

assistant: **Innovation**

During tumour progression, proliferating tumour cells lose their polarized epithelial phenotype, acquire an invasive phenotype and metastasize to other organs in the body. These processes frequently kill the cancer patient, however, little is currently known about the mechanisms that underlie tumour invasion and metastasis. To discover how cells develop an invasive phenotype, we will study epithelial plasticity, with particular focus on epithelial-to-mesenchymal transition (EMT) both in vitro and in vivo. We will identify the signalling pathways and genes involved and determine how they are regulated and their specific functions. We will then use this information to determine the importance of these processes in carcinoma progression and metastasis. We aim to define new targets for cancer therapy and novel markers for diagnosis and prognosis. The training objectives of this interdisciplinary network are to expose young researchers at the PhD and postdoctoral level to advanced techniques and new concepts that will help them become future leaders in cancer research.Cancer research is a highly challenging and multifaceted discipline. It is essential that cancer researchers have at their disposal a very wide range of techniques from a number of different disciplines, in particular, biochemistry, cell biology, molecular biology, developmental biology and tumour biology. Our objective is to train the young researchers in as many of these areas as possible through the network. None of the individual labs use all of these approaches, but through secondments, exchanges between the labs and network meetings, the young researchers will be able to become expert in many of these disciplines.Furthermore, flexibility and independence will be stimulated by exposing the researchers to f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bioavailability and degradability of organochlorine pesticides in contamined soil / groundwater', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective of the project is to evaluate the bioavailability and degradability of organochlorine pesticides: aldrin, dieldrin, heptachlor and the like, in contaminated soil and groundwater. Also their degradability will be assessed, using methanogenic granular sludge. Pesticides availability will be studied conducting their extraction studies from contaminated soil to determine the bioavailable phase. Also tests with adding dissolved organic carbon (DOC) will be carried out to find if it is possible to increase their concentration in the water phase, thus if it is possible to increase the biodegradable fraction. Simultaneously, selected pesticides biodegradation will be studied in tests using granular sludge. Adaptation, degradation rate and pesticides metabolites will be investigated thoroughly. Based on the results obtained during the research in the above two phases, a biodegradation experiments with real contaminated soil will be made. Finally, a design of a treatment concept to be applied in practice will be prepared.