RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Controlling the morphology of carbide MAX phases/MXenes through the starting carbon source' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

MAX phases, a family of inorganic layered compounds with a unique combination of metallic and ceramic properties, have found interesting applications in several fields: high temperature coatings, joining, catalysis, sensing, biomedicine, solar energy harvesting, and energy storage... Although MAX phases have been known since the early 1960s, little attention has been paid to the effect that the starting reagents may have on the morphology (and, therefore, properties) of the final material. Thus, for the particular case of the syntheses of carbide-MAX phases, the key question that arises is: could the carbon source serve as a template and somehow transfer its morphological features to the resultant product? MorphoXene project aims at preparing Ti3AlC2 (MAX phase) and Ti3C2Tx (MXene) with unconventional zero-, one-, and three-dimensional (0D, 1D, and 3D, respectively) morphologies by choosing a carbon source (template) distinct from the typically used graphene powder: i) 0D (C60-Ih)[5,6]fullerene (C60), ii) 1D single-walled carbon nanotubes (SWCNTs) and iii) the 3D hierarchically porous graphitic architecture resultant from the pyrolysis of Hippospongia communis, the most common marine sponge in the Mediterranean Sea. Moreover, in virtue of their shorter diffusion paths and/or the hierarchically porous structure in contrast to conventional MXenes, the performance of 0D, 1D, and 3D Ti3C2Tx compounds as anode materials in lithium-ion batteries (LIBs) will be tested and compared with that of the state-of-the-art Ti3C2Tx MXenes. This project will enable the Researcher to acquire professional maturity in the preparation of advanced materials with tailor-made properties. Moreover, it is expected that a better control over the morphology brings MXenes closer to their integration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering the structure and dynamics of the early spliceosome assembly' under Horizon 2020.

assistant: **Concept**

Pre-mRNA splicing is the major step of RNA edition in eukaryotes. It consists on a catalytic process that removes non-coding sequences (introns) and ligates the coding ones (exons), creating the RNA sequence that codifies the final protein. This process is highly regulated and gives rise to a great variability of proteins, expanding the versatility encoded in the human genome. In the early stage of splicing, RNA 5’ and 3’ splice sites must be brought within proximity to correctly assemble the active spliceosome (cross-intron arrangement) and perform the excision and ligation reactions. Many elements participate in the assembly of the early spliceosomal complex (E complex) through different protein-protein, protein-RNA and RNA-RNA interactions, leading to the formation of a very dynamic association. Several factors regulate the correct assembly, defining the RNA sequences that should be excised and controlling the production of alternative spliced transcripts. The full comprehension of the E complex formation will allow a deeper understanding of the splicing mechanism at molecular level which is essential in human health as aberrant processes are the basis of many diseases. Currently, the structures of cross-intron arrangement factors in the early spliceosome are not known and there is a lack of structural data of the complete E complex. In this project, I propose a novel, integrative and multidisciplinary study of the structure and regulation of the early spliceosomal assembly. I will analyse the different cross-intron interactions, elucidate the high-resolution structure of the whole association and study the effects of protein post-translational modifications in the structure and complex assembly. This will lead to the discovery of new structural insights for the firs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A SEMANTICALLY-ENHANCED MARKETPLACE OF INTEROPERABLE PLATFORM-AS-A-SERVICE OFFERINGS FOR THE DEPLOYMENT AND MIGRATION OF BUSINESS APPLICATIONS OF SMEs'.

assistant: **Innovation**

The 36-month PaaSport project focuses on resolving the application portability issues that exist in the Cloud PaaS market through a flexible and efficient deployment and migration approach. To this end, PaaSport will combine Cloud PaaS technologies with lightweight semantics in order to specify and deliver a thin, non-intrusive Cloud-broker (in the form of a Cloud PaaS Marketplace), to implement the enabling tools and technologies, and to deploy fully operational prototypes and large-scale demonstrators.PaaSport will enable European Cloud vendors (in particular SMEs) to roll out semantically interoperable PaaS offerings leveraging their competitive advantage and the quality of service delivered to their customers, making their offerings more appealing and improving their outreach to potential customers, particularly the pan-European software industry. PaaSport will also facilitate European Software SMEs to deploy business applications on the best-matching Cloud PaaS and to seamlessly migrate these applications on demand. Therefore, PaaSport contributes to aligning and interconnecting heterogeneous PaaS offerings, overcoming the vendor lock-in problem and lowering switching costs.From a business perspective, PaaSport aims at lifting the barriers that cause the vendor lock-in problem, thus empowering Cloud customers and Cloud application developers (in particular, European SME Software vendors) and allowing them to choose freely the Cloud PaaS offering that best fits their needs. PaaSport is also expected to empower the position and encourage the entrance of European SME Cloud vendors, such as Flexiant, in an emerging market which is currently dominated by American colossi, such as Google and Amazon. In order to maximize the communities awareness and adoption of the PaaSp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Avian influenza: impact of virus-host interactions on pathogenesis and ecology'.

assistant: **Concept**

Highly pathogenic avian influenza viruses (HPAIV) have acquired the unprecedented and alarming capability to infect humans. By establishing a permanent ecological niche in wild birds, HPAIV will pose a continuous risk for poultry and fatal human infections, especially if these birds excrete HPAIV without showing any clinical signs of disease. These changes in the ecology of the disease and behaviour of the virus may create opportunities for a pandemic virus to emerge. Attempts to avoid or contain HPAIV outbreaks have been largely unsuccessful. This can be directly linked to our lack of fundamental knowledge. Therefore, it is essential to increase our knowledge of the ecology and pathology of avian influenza virus infections in poultry and other species.Full understanding of the ecology and pathogenesis of HPAIV requires a multidisciplinary approach determining host-pathogen interactions and the role played by the host immune response. To this end, the FLUPATH consortium was established. FLUPATH is composed o f 13 partners, 6 of which are National Reference Laboratories for avian influenza. The consortium further includes 5 academic institutions and 2 institutions specialized in animal science and health.The participants, with expertise in chicken genomics, micro-array technology, pathology, receptors, innate immunity and chicken immunology, will use multidisciplinary and complementary approaches to address key problems and unanswered questions with respect to the ecology and pathogenesis of avian influenza. FLU PATH will provide knowledge and tools for new strategies which will be tailored for the control and management of avian influenza at the European and International level. This will limit the impact of this disease on human health and losses to the poultry industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Patient-specific tumour growth model for quantification of mechanical 'markers' in malignant gliomas: Implications for treatment outcomes.' to be submitted under Horizon 2020.

assistant: **Abstract**

Gliomas are the most frequent primary brain tumours in adults (70%) with  Glioblastoma multiforme (GBM) being the most frequent and most malignant sub-type (about 50%). Their growth is characterised by infiltration of surrounding healthy tissue, rapid proliferation, and the formation of a necrotic core. GBM growth often creates biomechanical forces that cause compression and displacement of the surrounding brain tissue. This mass-effect is of direct clinical importance; it correlates to functional loss and pressure-induced brain herniation is the leading cause of death for 73% of patients, however this is not used to inform treament. Overall long term prognosis for GBM remains poor, with median overall-survival below 1.5 years and 5-y survival rates below 3%.We hypothesize that  biomechanical Glioma “phenotypes” can be distinguished by mathematical models that estimate the forces that produce tissue displacement. Forces building up as a result of tumour growth might alter the behaviour of cancer cells and can reduce blood perfusion by compressing intra-tumoral blood vessels thus affecting drug delivery. We therefore expect that biomechanical factors may have direct implications not only on the biophysical level, but also for clinical decision making, affecting treatment response and outcome.This project seeks to understand the role of biomechanics in the formation of different GBM phenotypes, and to identify “biomechanical markers” that can be used to inform clinical decision making for individual patients.A mathematical model of tumour growth and biomechanical tumour/healthy tissue interaction will be developed and characterised in a multi-step validation procedure. This model will be tested with clinical data and may allow for characterisation of the biomechanical fin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Multipurpose hemp for industrial bioproducts and biomass'.

assistant: **Concept**

Hemp is a sustainable high yielding crop well adapted to most European conditions, with advantageous environmental and agronomical characteristics. Traditionally cultivated for the fibres, seeds and psychoactive substances, it is now considered an ideal crop to produce innovative biomaterials. Once a key industrial crop for fibre, hemp production declined in the last century and was displaced by cotton and synthetic fibres. This explains why hemp has not been subject to the intensive breeding that has driven great improvements in major food crops in the last 50 years. However, cotton has one of the worst environmental footprints of any crop and there is renewed interest in hemp because it requires less water and agrochemicals and provides fibre and oil of superior quality. In the frame of multi-hemp, we will use cutting-edge genomic approaches to achieve rapid targeted improvements in hemp productivity and raw material quality for end-user requirements, whilst also advancing scientific understanding of gene-to-trait relationships in this crop. This work will be combined with innovations in agronomy, harvesting and processing methods to generate sustainable products from improved varieties. The project will include demonstration activities such as field trial and process scale up. The economic and environmental implications of each innovation will be assessed so as to maximise economic return and increase sustainability. This project brings together leading research groups with a vibrant group of industrial participants working from the level of molecular genetics through to end product demonstration. Our ambition is to develop an integrated hemp-based biorefinery in which improved feedstock is subject to efficient and modular processing steps to provide fibre, oil, cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Designing Bifunctional Nano-Alloy Catalysts for Bio-Renewable Feedstock Valorisation' (BIFUNC-NANOCAT) targeting Seventh Framework.

assistant: **Abstract**

The principal goal of “BIFUNC-NANOCAT” is to develop efficient and selective bi-functional catalyst systems having both acid/base catalysed and an oxidation functionalities for the valorisation of biomass to produce bulk/speciality chemicals effectively in an environmentally benign route. Oxidative valorisation of the lignin and cellulosic constituents of biomass for the production of value added products by bi-functional heterogeneous catalysts using environmentally benign oxidants like O2 or H2O2 in a green solvent medium is the key aspect. The proposed bifunctional nano-alloy catalyst will also be tested for the oxidation of bio-renewable feedstock materials (platform molecules) and model compounds using green oxidants like O2 or H2O2 in an ionic liquid medium replacing stoichiometric oxidants like permanganates or chromates. We intend to use the catalysed oxidative dehydrogenation of bio-renewable benzylic alcohols (e.g., veratryl alcohol, vanillyl alcohol and cinnamyl alcohol) as a substrate activating strategy for the synthesis of amines, benzimidazoles, and as a general strategy for the N-alkylation of amines in a single pot. In situ spectroscopic techniques, like ATR-IR, UV-Vis, Raman, along with X-ray absorption methods (e.g. XAFS, including XANES and EXAFS as well as related microscopy methods, such as STXM), coupled with isotopic labelling studies would be employed to understand the interaction between substrates and catalysts, especially to characterize the adsorbed species and the compositional effects of the nano-alloys made and during catalytic reaction. It is proposed to study the feasibility of performing some of the above mentioned reactions in a continuous fashion using different reactors like fixed bed reactor (FBR), micropacked bed reactors (MPBR)."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Increasing the genetic variation of wheat germplasm by introgressing Thinopyrum intermedium chromosomes and chromosome segments'.

assistant: **Objectives**

Wheat is the predominant cereal in Europe and one of the major export products of the European Union. There is an increasing demand to preserve EU wheat-production potential and ensure long-term food security for European citizens. However, wheat is facing such major challenges as climate change, and the narrowed genetic background of cultivated wheat cannot surmount such difficulties. Wild relatives possess great genetic diversity, including tolerance to abiotic stresses, perenniality and disease resistance. The transfer of genetic diversity from wild species to wheat could give valuable responses to the effects of climate change. Breeding a new wheat variety takes 7-10 years, so in order to develop new, competitive varieties by 2020, initial crosses need to be done now.Species belonging to the Thinopyrum genus are of particular importance as they provide perenniality, salt and drought tolerance and disease resistance. The present study aims to provide innovative tools for shaping more efficient breeding programmes in the future. A new crossing strategy will be presented, resulting in genome-wide introgressions from wheatgrass (Thinopyrum intermedium) in only two generations. Subsequently a new Single Nucleotide Polymorphism (SNP) marker technology will be developed by exploiting recent advances in Next Generation Sequencing platforms (NGS) to provide cheap and easy to use molecular markers for Marker-assisted Selection (MAS) in breeding programmes. Introgressions will be validated by modern molecular cytogenetic techniques (genomic in situ hybridization, fluorescence in situ hybridization) and phenotyping will be carried out for disease resistance and perennial growth habit. The exploitation of these valuable tools in wheat improvement will enable the breeding of comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Propagation of european pines via somatic embryogenesis', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

A method will be developed for vegetative propagation of two economically important pine species, Pinups Sylvester's and P. pilaster, by using somatic embryos. The method will be based on knowledge about how somatic embryos of pine proliferate and develop and how the different steps are regulated. The best growth conditions for the in vitro steps, especially for maturation, will be defined, allowing establishment of vigorous plants under outdoor conditions. The method will be approved for seed families of high value for forestry. Embryogenic cultures will be cryopreserved. Somatic embryo plants will be regenerated. The potential of the method will be assessed by the end users by comparing the early performance of regenarated somatic embryo plants to seedlings from the same families and estimating wether the plant material of interest is multiplied in a satisfactory way.Part 1. Embryogenic cell lines from 433 genotypes of P. sylvestris and 1039 genotypes of P. pinaster selected by the forest industry were established and cryopreserved. More than 4400 somatic embryo plants of P. pinaster and more than 3700 of P. sylvestris were regenerated from the cell lines and about 2500 of the P. pinaster and about 680 of the P. sylvestris plants were transferred to nurseries or field.Part 2. A. Increased understanding of how somatic embryos of pine proliferate and develop. Time-lapse tracking was carried out during proliferation and development of somatic embryos in order to learn how embryo formation and development proceeds. Two major mechanisms of multiplication of early somatic embryos in pine were characterized: embryo formation through meristematic activity in the secondary suspensor, alternating with cleavage polyembryony. The multiplication rate is very high and it is difficu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of molecular markers for multi-identification of pathogenic piroplasmidae, in cattle and their vectors, in the South of Europe'.

assistant: **Objectives**

Research objectives and content This research project plans to develop a multi-identification system for cattle piroplasmidae in Spain and Italy where unspecified theileriosis have been observed bycolleagues we are working with for several years. By collecting samples in the field (cattle blood and alive ticks) with local scientists we will try to identify the parasite involved in carrier state or outbreaks in the targeted areas. Tick vectors will be identified and a prophylactic approach could be developed with an adequate vaccination strategy to reduce the costs of such diseases. This project will not only involve different European countries whose dairy and meat industries are threatened but will allow to produce a DNA bank for the other European countries interested in such livestock infection. Training content (objective, benefit and expected impact)  This project will help the candidate to improve his technical skills by using new molecular techniques and applying them to field situations. He will be able to develop European links and to enhance an International career on epidemiology applied to livestock animals. This should be of particular benefit to the European meat and dairy industries. Links with industry / industrial relevance (22)  No direct links have been prepared for this research project but dairy and meat industries in the EU touched by theileriosis should increase their productivity.