RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Elucidating the role of nuclear metabolism in embryo implantation' (NucMeta), addressing dissemination and exploitation.

assistant: **Impact**

Embryogenesis involves dynamic epigenetic and transcriptional changes as the zygote divides and cells differentiate into embryonic (epiblast) and extra-embryonic (primitive endoderm and trophectoderm) lineages. Metabolites serve as cofactors or substrates for chromatin-modifying proteins, thus shaping the global epigenetic landscape. Intriguingly, during early development, multiple metabolic enzymes translocate to the nucleus where they might fuel chromatin modifiers. How the interplay between nuclear metabolism and epigenetics regulates cell fate transitions remains unclear. With this proposal, I aim to unveil the role of nuclear metabolism in regulating lineage-specific phenotypes during early development, using implantation as a model. I will focus on this developmental stage as it is characterised by dynamic metabolic and chromatin rewiring. Since implantation relies on proper trophectoderm specification and maturation, I will use embryonic stem cell-derived trophoblast stem cells that transit between pre- and post-implantation-like states in vitro. Specifically, I will establish novel tools to target the degradation of key metabolic enzymes exclusively in the nucleus and assess the impact on gene expression and chromatin modifications. Moreover, I propose to identify the genomic targets and protein partners of nuclear metabolic enzymes. Ultimately, the integration of transcriptomic, genomic, and epigenomic data will unveil the metabolic determinants underlying gene expression and epigenetic changes at implantation.


**Keywords:** metabolic regulation, chromatin modifications, metabolic enzymes, implantation, trophoblast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Feasibility study for Bioapplications – BioBalanced Farm probiotic'.

assistant: **Objectives**

A rapid emergence of resistant bacteria occurs worldwide, endangering the efficacy of antibiotics, which have transformed medicine and saved millions of lives. The antibiotic resistance crisis has been attributed to the overuse and misuse of these medications. 700 000 patients die annually as a result of infections caused by antibiotic resistant bacteria. Due to a growing demand to substitute medicine and hazardous chemical usage in agriculture, Bioapplications developed the BioBalanced Farm Probiotic – a unique probiotics blend, which is misted in the facility, naturally excludes pathogenic bacteria and prevent mutation and development of resistant bacteria. The Solution also strengthens immune system, improves the welfare and increases the mass of the livestock, reduces bad odours, and generally improves a quality of meat. Consequently, farmers are able to fight. According to Eurostat, there were 331.16 million Livestock Units (LSUs) in 2017 – 44.47% were pigs, 26.9% were cows, 26.3% were sheep’s and 3.9% were goats. Since pigs are the most prevalent in Europe and antibiotics are heavily overused in pig farms, the commercialisation of the solution will be firstly focused on pig farms. With a total of 147.24 M pigs in EU-E8, the total available market size for BioBalanced Farm probiotic is 88.34 M square meters. Bioapplications will enter the market by targeting large pig farms in home market Denmark, followed by Spain, Germany, the Netherlands and Belgium. After a successful commercialisation, Bioapplications plans to scale-up by expanding into other EU regions and providing the service to poultry and cows farms.Commercialisation strategy includes three steps: preparation for market entry (home markets), market replication (large pig farms in target countries) and sca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Defect passivation for two-dimensional (2D) magnetic semiconductors' (2D).

assistant: **Concept**

The unique integration of magnetic and semiconducting properties in 2D magnetic semiconductors opens new opportunities for controlling charge and spin degrees of freedom, crucial for developing advanced spin-based technologies. Among these materials, 2D van der Waals CrSBr stands out due to its strong coupling between magnetic and electronic structures. However, the unexplored passivation strategies and unclear defect mechanisms hinder its advancement for nanoscale opto-spintronic devices. Defect M is designed to establish innovative chemical passivation methodologies to achieve high-quality and stable 2D CrSBr with a comprehensive understanding of defect physics, which not only allows us to gain a better understanding of the degradation mechanism but is also critical to enable reliable studies of spin- and charge-based phenomena. This highly interdisciplinary project facing key future technologies will pave the way for next-generation spin-based devices and benefit the upcoming EU's priorities of digital transformation and green transition.


**Keywords:** 2D magnetic semiconductors, defect passivation, synchrotron radiation, ultrafast optical spectroscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'a Study of Egyptian Animal Mummy Styles' (SEAMS) under Horizon Europe.

assistant: **Objectives**

The SEAMS project aims to investigate the wrapping weaves of votive animal mummies, a religious phenomenon which was widely spread throughout Egypt between the Third Intermediate Period and the Roman Period (1069 BCE-380 CE ca.). SEAMS is set to fill the gap in current knowledge on the contextual data of votive animal mummies and shed light on their manufacture through an innovative multidisciplinary and interdisciplinary methodology that integrates traditional research approaches with new technologies. This study has never been undertaken before since Egyptologists have long paid relatively little attention to these artefacts. The project will contribute to the advancement of this field by reconstructing the original integrity of the wrapping patterns of specimens held in international museums through photogrammetry, MSI techniques, and virtual restoration. The multi-scalar and cross analysis of the restored 3D replicas and their related data allows the recurring patterns to be identified and grouped into typologies. The stylistic assessment of recurring wrapping weaves combined with further information from archives, fieldwork, and CT-scans enables their occurrence within a specific period and/or site to be recorded and any potential meanings unravelled. Textile and experimental archaeology protocols are set to provide an understanding of how the bandages were held in tension, what the interweaving stages were, and which tools were used. Furthermore, a comprehensive account of the quality and quantity of the resources, technologies and efforts employed permits an evaluation of the economic weight of the wrapping procedures. The research outcomes are to be widely shared through open science practices, outreach activities, a free and open access visual repository, and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Sound of Empire in 20th-c. Colonial Cultures: Rethinking History through Music'.

assistant: **Innovation**

To better understand cultural relations in today’s multi-ethnic, multicultural societies, we need to revisit the legacy of modern empires. This project delves into the musical dimension of the French empire and what differences were negotiated through aurality, long-neglected by historians. Focusing on musical life and media from Dakar and Rabat to Saigon, 1900-1962, it studies how music was practiced, heard, and understood in a variety of colonial contexts. Crucially important is the need to investigate the tastes, practices, and interactions of Europeans and natives, usually studied in isolation. Such scope requires an entirely new methodological paradigm: relational, comparative, and integrative-synthetic. Traversing disciplinary boundaries separating musicology from history, media studies, and ethnomusicology, the project has four objectives: (1) To musicalize history, it probes what musical fields of production contribute to current debates on the nature of empire and colonial identities. (2) To historicize aural media, it examines live and recorded music on radio as windows on the dynamic nature of colonial coexistence. (3) To globalize music history, it brings new coherence with its focus on a single empire and without imposing postcolonial models of domination/resistance. (4) To creolize research, it integrates indigenous research and promotes dialogue with collaborators from the former empire. Foundations laid by the PI’s prior research in colonial archives, availability of sources, each team member’s expertise and focus on one field, their shared method, and common purpose insure its feasibility. This pioneering study of the modern French empire through music will generate new insights into its mechanisms and constituencies, taking colonial, media, and music h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Business Model Innovation in Living Labs' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The principle aim of the BUMILLA research programme is to create a long term strategic partnership between the School of Engineering & Applied Science at Aston University (AU), the University of Gothenburg School of Business, Economics and Law (UG) and Insero E-Mobility (IEM) an entrepreneurial SME dedicated to changing the international EV landscape through the innovative use of living labs.The partners enter the project aspiring to strengthen their knowledge and expertise through a cross-disciplinary collaboration aiming at enabling a wider scale take up of EV technologies.This will be achieved through an exchange of personnel between the two universities and the SME and the temporary recruitment of an experienced researcher.The project contains a state-of-the-art research programme, systematic knowledge transfer and an impact scheme that collectively has the potential to strengthen the competitiveness of the European Union in the field of EV technology uptake in relation to international competitors.The research programme contains three overall S&T objectives within the general aim of enabling a wider scale take up of EV technologies:S&T O1: To conduct multidisciplinary research on product user profiles in living lab product testing (the role of technology architecture)S&T O2: To develop a framework for business model innovation in living lab settings (the role of business models)S&T O3: To experiment with public-private partnership (PPP) models supporting a combined technology and business model approach (the role of the coherent framework).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Synthetic Optical Holography' to be submitted under Horizon 2020.

assistant: **Abstract**

Holography has paved the way for phase imaging in a variety of wide-field techniques such as optical microscopy. In scanning optical microscopy, however, the serial fashion of image acquisition seems to challenge a direct implementation of traditional holography. Recently, the applicant and supervisors have jointly invented synthetic optical holography (SOH), which is a new holographic modality for fast scanning phase imaging. SOH has already been implemented in scanning near-field microscopy (s-SNOM) (improving imaging speed by a factor of 50 in comparison to standard technology) and in confocal microscopy (enabling optical surface profiling based on the measurement of the optical phase). SOH has great potential for a widespread implementation in diverse scanning microscopy methods, however, the full potential of the method has not been discovered yet.During the outgoing phase at UIUC, we will develop a totally new imaging modality in Stimulated Raman Scattering (SRS). Namely, we will apply SOH to holographically detect the Raman signal to increase speed and sensitivity of current SRS technology. We will furthermore develop novel holographic schemes for spectroscopic phase imaging. Having tested these novel holographic schemes with existing confocal microscopes during the outgoing phase, we will implement them in near-field microscopes at CIC nanoGUNE during the return phase. The goal is to achieve a technological milestone in near-field microscopy, which is the rapid recording of a near-field image where each pixel contains the local amplitude, phase AND spectral information. This new technology, called rapid hyperspectral nanoimaging, is expected to greatly extend the applicability of near-field microscopy for the chemical and structural identification of biological
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Renewable Power Generation by Solar Particle Receiver Driven Sulphur Storage Cycle' (PEGASUS) targeting Horizon 2020.

assistant: **Abstract**

PEGASUS (Renewable Power Generation by Solar Particle Receiver Driven Sulphur Storage Cycle) will investigate a novel power cycle for renewable electricity production applying a solar particle receiver with a sulphur storage system for baseload operation. The proposed process combines solid particles as heat transfer fluid that can also be used for direct thermal energy storage with indirect thermochemical storage of solar energy in solid sulphur, rendering thus a solar power plant capable of round-the-clock renewable electricity production.  Concepts of solar sulphur power plants will be developed and a flowsheet analysis in conjunction with a techno-economic study will be carried out to simulate the performance of the process. Prototypes of the key components (i.e. solar centrifugal particle receiver, sulphuric acid evaporator, sulphur trioxide decomposer and sulphur combustor) will be developed, constructed and operated at relevant scale. On-sun testing of the particle receiver will be carried out in the newly constructed high-flux solar simulator of the German Aerospace Center (DLR) in Juelich, Germany. Furthermore, an integrated operation of the receiver together with the evaporator and the decomposer will be realised in this facility to demonstrate the suitability of the concept. In addition, materials to be used simultaneously as solar heat capture, transfer and storage media as well as catalytic particles in the solar receiver, evaporator and decomposer will be developed, tested and analysed with respect to reaction kinetics and long-term stability. Moreover, system models of the key components will be implemented, validated with experimental data and applied to simulate the performance of the process components. These models will be integrated into the develope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tropospheric halogens - effect on ozone.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

THALOZ is a concerted, multidisciplinary effort aimed at understanding of the role of reactive halogens in troposphere oxidation chemistry, their effect on ozone, and consequent influence on radiative forcing of climate by greenhouse gases. The workplan combines satellite observations, laboratory studies, model development and model application. New information will be obtained on the amounts of reactive halogen species in the troposphere and on the key chemical reactions controlling them. The models will be used to assess the regional and global distribution and budgets of halogens and their effect ozone in the troposphere , and the changesradiative forcing due to halogen chemistry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ligand Directed NIR-based Theranostic Prodrugs for Prostate Cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Cancer remains one of the leading causes of mortality worldwide. Prostate cancer (PC) is currently the most common male malignancy and remains the leading cause of death. Despite advances in chemotherapy, current strategies still carry severe side effects and offer limited benefit to the patient. Two main reasons behind these limitations include 1) non-specific delivery of anticancer drug to the target tissue and 2) poor diagnosis at an early stage of the disease. Thus, there is an urgent need for a novel and modular theranostic platform to deliver drugs selectively to cancer tissues and simultaneously follow therapeutic efficacy through non-invasive imaging techniques. Herein we propose a DT-diaphorase activated, DUPA guided NIR-based theranostic strategy to deliver anticancer drug selectively to prostate cancer cells while monitoring in real-time drug release and efficacy in vivo. The developing tool is novel and modular, enabling the use of various triggers, drugs and targeting agents. The fluorophore signal is expected to fall in the NIR region (>600 nm) and the scaffold with enable as real-time monitoring of drug release in vivo, as well as the introduction of targeting groups in order to improve the specificity of the theranostic agents towards cancer cells. The development of this technology can provide an invaluable platform that can be easily adapted for the treatment of different cancer types. It is likely that the directness and modularity of this novel approach will have a strong impact in the field of targeted drug-delivery for treating and monitoring in real-time drug effectiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fundamental understanding of reactive nitrogen in the global upper troposphere' under Horizon 2020.

assistant: **Concept**

The upper troposphere (UT), a severely under-researched part of the atmosphere, has profound impacts on global climate, air quality, major atmospheric oxidants, and the protective ozone layer. Key to its influence on the Earth system are reactive nitrogen compounds (collectively NOy). Models, since their inception, have grossly misrepresented observations of UT NOy, hindering application of these models to accurately estimate the impact of humans on climate, the ozone layer, and air quality. The reasons proposed for discrepancies between models and observations are unsatisfactory, as past studies have been hampered by observations that are limited in space and time. Only now are there unprecedented global, high-resolution measurements of the UT from instruments on aircraft and satellites that can be combined with detailed and advanced modelling tools to at last tackle this issue on a global scale. The ground-breaking UpTrop work programme will innovatively combine observations from the recently launched ESA Sentinel-5P mission and a long record of aircraft campaigns (most crucially the 2016-2018 NASA ATom campaign) to create the first truly global dataset of UT NOy abundance, interpreted with the state-of-the-art GEOS-Chem model. This pioneering multiplatform approach, the bedrock of my previous highly cited work, will deliver game-changing objectives: (i) novel insights into the processes controlling UT NOy, (ii) an unequivocal account of the role of the upper troposphere in altering climate and the chemical composition of the atmosphere, and (iii) interpretation of the disruptive impact of improved understanding of UT NOy on widespread application of satellite observations to constrain global air quality. UpTrop is ambitious, with bold objectives that will conceptuall