RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Improving the Innovation Management Capacities of SMEs' to be submitted under Horizon 2020.

assistant: **Abstract**

The InnovImp proposal is designed to provide in-depth innovation management support services to SMEs based in the Maltese Islands due to an absence of such affordable assistance in the market.  The proposal also outlines how beneficiaries of the H2020 SME Instrument will receive specific support by the Enterprise Europe Network through the supported coaching assignments addressing innovation weaknesses.  The service portfolio outlined in the InnovImp proposal being funded under H2020, totally complements the other actions being funded under the COSME programme and the proposal ensures that the right synergies will be created to result in the desired impact particularly by removing the innovation management inefficiencies of the client SME.  For instance, whereas under COSME new innovation opportunities through partnering may arise, the new services funded under this H2020 call shall enhance the innovation management performance of the enterprise. In this way making their innovation processes more effective and efficient or, specifically for the beneficiaries of SME instrument identifies barriers to might hinder the SME to realise economic impact from its supported project. InnovImp foresees the use of dedicated assessment tools to gauge gaps and weaknesses in the client's innovation process, and these will be based on the latest CEN definition of an innovation management system. The InnovImp proposal supports and endorses the objectives outlined in the Competitiveness of Small and Medium Sized Enterprises [COSME] and Horizon2020 [H2020] programmes which both anticipate new and enhanced support mechanisms to help European SMEs. Moreover the delivery of such services through the only Enterprise Europe Network in the Maltese Islands strengthens the relevance of this work p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Technology Platform for Point-of-Care Diagnostics for Tropical Diseases - EU' (PodiTrodi-EU).

assistant: **Innovation**

The diagnosis and discrimination of infectious diseases (such as leishmaniasis, dengue, malaria, HIV, chagas) in geographic regions with poor or low-density medical infrastructure is of high socioeconomic importance. While so-called rapid in-vitro diagnostic (ivD) tests" for single diseases are already on the market, more complex analytical protocols are necessary to clearly identify a certain tropical disease AND to determine the status of the disease - the latter being crucial for proper treatment. Such complex analytical protocols would include liquid handling as well as sample preparation like transcription and amplification (PCR) of the virus` RNA (dengue, HIV) or the parasite (lechimaniasis, malaria, Chagas). These sample preparation steps are currently only available in laboratories and have not yet found their way in mass-producible, integrated point-of-care diagnostic tests.Thus, the PodiTrodi project aims to overcome the draw-backs of current Point-of-Care tests by developing technologies for really integrated (but low-cost!) sample preparation. The prototype to be developed for this proof of concept will be an instrument that integrates the heterogeneous Microsystems (biosensors and microfluidics), control electronics, sensor read-out, human-machine interface, embedded processor and power supply, in a self-contained unit, suitable for point-of-care diagnosis of the diseases selected as first targets.To achieve these challenging goals, PodiTrodi follows a multidimensional, multi-material system integration approach on four project "levels" (Heterogeneous System Integration, Instrumentation, Fabrication Infrastructure, Development Infrastructure). The Consortium comprises 8 partners from 5 European countries (Germany, France, Italy, Finland, Portugal) as well a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Diverse Knowledges and Sensing Practices in Peatlands for Inclusive Climate Futures'.

assistant: **Innovation**

PEATSENSE will devise and test a ground-breaking approach to decision-making in peatland sites designated priority areas in recent climate assessments, redefining the meaning and practices of inclusion for future global climate mitigation. The project is contextualised by an important ecological challenge: we now know that although peatlands cover only 3-4% of the earth’s surface, they hold 33% of its carbon reserves. Following paradigm-shifting findings in biophysical research on the role of peatlands in the global carbon cycle, a suite of policy pathways and governance initiatives have been proposed to incentivise and monitor peatland conservation. However, many of the proposed interventions have been shaped without a clear understanding of why and how ecological degradation occurs in the first place, or how interventions will affect those living in and near peatlands. By imagining peatlands as places without people, or as inaccessible sites people do not depend upon, policymakers frame the problem of peatland conservation as a technical one. Yet the question of how to conserve peatlands is political because it is a matter of ‘who gets to decide’ how environments are managed, and in whose interests. Multinational corporations and banking institutions are major players in the investment packages on the table, and private investors stand to gain considerably from new governmental subsidies. Meanwhile, even ‘nature-based’ restoration practices such as rewetting impact on local agricultural and cultural practices in important ways. PEATSENSE will provide the missing investigation into the politics of knowledge surrounding peatland conservation to combat social exclusion and diversify decision-making processes. By analysing configurations of climate expertise in relation t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A search for the function of MYB transcription factors in plants' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of this proposal is to carry out a systematic search for the function of all members of one family of transcription factors in Arabidopsis. The members of the myb gene family contain a highly conserved DNA-binding motif, which has permitted the isolation of partial cDNAs representing over 80 members of the Arabidopsis myb gene family as part of the Biotech and Arabidopsis genome programmes. The functions of a few of these genes are beginning to be understood using a combination of genetical and biochemical analysis in several species. Consensus target sites in promoters have been identified, and some Myb proteins have been shown to activate transcription of target genes encoding enzymes of biochemical pathways. Other members of the family control cellular differentiation, and plant responses to environmental challenges such as UV light, water stress, mechanical damage and defence responses against pathogens. However, it is clear that because the functions of most of the members of this unusually large gene family are unknown, and because of the important and diverse cellular functions of characterised Mybs, the full range of the regulatory influence of this gene family is not yet appreciated and promises to be very significant. This project aims to identify the function of most members the myb gene family in Arabidopsis using a PCR-based strategy to screen systematically for insertion mutations in each of the myb genes. Such strategies have been successfully established in Drosophila and Caenorhabditis, and have recently been applied to mutagenized plant populations. Such a systematic search promises to be both the most efficient route for determining gene function and will also provide the most comprehensive and readily applicable knowledge of the genes and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification and Structural Inference of Dynamic Causal Effects: Theory and Applications' (ISIDCE).

assistant: **Innovation**

Identification of causal effects from non-experimental data is a difficult task because of the scarcity of plausible exogenous variation in the data. Typically, variation in the ‘treatment’ variable, such as a policy intervention, is not independent from relevant but unobserved characteristics of the underlying causal relationship. Causal inference often relies on the availability of valid instruments. A serious threat to the internal and external validity of econometric inference arises when the instruments are weak. This problem is well documented and is pervasive across most areas of economics.The proposed research will make a number of methodological and applied contributions to the current state of the art. First, it will provide improved methods of inference that are robust to the problem of weak instruments. Second, it will propose new approaches to the identification of dynamic causal effects that is particularly relevant for the analysis of macroeconomic policy. Third, it will apply state of the art econometric methods to the study of unemployment and business cycle fluctuations, with particular emphasis on European data.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Exploitation of microalgae diversity for the development of novel high added-value cosmeceuticals'.

assistant: **Concept**

Microalgae have the potential to revolutionize biotechnology in a number of areas including nutrition, aquaculture, pharmaceuticals, cosmeceuticals and biofuels. AlgaeCom project seeks to exploit the microalgae biodiversity, as a source for state-of-the-art high-added-value cosmeceuticals. The project will combine both basic and applied research in the fields of –omics technologies, biochemistry and applied biotechnology in order to, a) Develop catalomics, metabolomics and glycomics resources for microalgae diversity as a valuable source of novel high-added-value cosmeceuticals such as polysaccharides, enzymes and secondary metabolites; b) In vitro functional characterize and toxicologicaly analyse microalgae cosmeceuticals using human epidermal cell lines and in vitro skin model; c) Develop and optimize application-based microalgae culture systems at different scales and optimize culture conditions for higher production rate of desired products; d) Develop analytical molecular diagnostic tools for real-time monitoring of the microalgae carbohydrate and polysaccharide metabolism in large scale cultures; e) Develop, formulate and in vitro evaluate cosmetic products based on microalgae cosmeceuticals (enzymes, small secondary metabolites and polysaccharides). The AlgaeCom project will offer the opportunity for the development of well defined end products (cosmetic products, RT-qPCR molecular tools) to industrial partners. Finally, the integration of advanced research with an efficient mechanism for transfer of knowledge, training and dissemination will contribute favourably to the reinforcement of the collaboration between academia and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cloning and analysis of AP-1-dependent target genes involved in cell transformation, apoptosis and defence against genotoxic agents' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives:?Construction and inducible expression of dimer-specific mutants of AP-1 subunits in tissue culture cells.?Generation and analysis of mice with altered AP-1 subunit abundance. ?Isolation of new, dimer-specific target genes.?Functional analysis of target genes in cell transformation, apoptosis and cellular defense.Brief description:Physiologic and cancerous cell growth are determined by a balance of the regulatory processes that lead to either cell proliferation, differentiation or programmed cell death (apoptosis). The transcription factor AP-1, representing a homo- or heterodimer of members of the Jun, Fos and ATF proteins subfamilies address specific yet unknown target genes whose gene products are critically involved in all three phenotypes. There is solid evidence that each AP-1 transcription factor has very defined target promoters and target genes. Understanding the function of AP-1 subunits and the specific program of target genes will elucidate important facets of cancer mechanisms and most importantly help to define targets for anti-cancer drugs.The goal of the project is to explore the properties and target genes of individual AP-1 dimers by decisively restricting their dimerization abilities by mutation. Specific AP-1 subunits that participate in the cancer process as well as in apoptosis and cell survival will be identified. Their link to upstream signaling pathways will be defined. Such knowledge will be the precondition to be able to manipulate their activities. From past experience it is already know that the role of a transcription factor and here specifically of a defined subunit combination, needs to be explored on both the cell culture level and in the intact organism. While the work in cell culture will yield such information as to which s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Dissection of signal transduction cascades regulating inter and intra-species interactions among phytoplankton assemblages in the marine environment'.

assistant: **Objectives**

Diatoms are among the most important groups of eukaryotic phytoplankton, responsible for 40% of marine primary productivity. Thus, understanding the molecular basis for their ecological success is therefore essential. Current knowledge of diatom perception and response to changes in the marine environment and the cellular cascades that mediate acclimation to stress conditions is fragmentary. Both [Caz+]cyt and Nitric oxide (NO) have recently been established as important secondary messengers in stress response s in plants and animals.The cross talk between these signalling molecules seems to be central in understanding the cascade leading to the determination of cell fate. My goal is to investigate the role of NO and Ca2+ as second messengers in marine diatoms in response to biotic interactions mediated by all elochemicals. In addition, I will study potential infochemicals as activators of the cell death/defence signalling cascade at the cellular and population levels indiatoms. The availability of a and quot;Ca2+ detection system and quot; in the host laboratory coupled with the instrumentation for the analysis of the cell and apos;s redox status, complemented by the use of genomic and post-genomic techniques will make the goal of this work achievable within the framework of my visit.Furthermore the host laboratory is responsible for the recent advances in diatoms, such as the development of gene transfer protocols and generation of 12,000 expressed sequence tags (EST and apos;s). The first complete genome sequence from a diatom (Thalassiosira pseudonana) has recently become available for understanding diatom biology. This research will allow dissection of the signal transduction pathways involved in inter- and intra-organismal dynamics in marine phytoplankton.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Research Coordination, assessment, deployment and support to HyCOM' under Sixth Framework.

assistant: **Concept**

Roads2HyCOM is a project to co-ordinate, assess and monitor research in the field of Hydrogen for stationary and transport power. Its outputs will support planning of future Hydrogen initiatives under FP7 and beyond (known as HyCom), which aim to develop hydrogen communities and stimulate growth in hydrogen technology markets. The project uses quantitative techniques to assess European and global technology, Hydrogen infrastructures, and the needs of generic community types which define thresholds required for successful Hydrogen Community application; considering technical, commercial, safety and socio-economic aspects of technology. In parallel, potential Hydrogen Community stakeholders will be engaged to support HyCom planning. This project will cover all aspects - the production of hydrogen, distribution, storage and conversion to useable energy by the end-user, in stationary and transport applications; and associated safety, security, regulatory and socio-economic issues. The project uses the expertise of independent research and technology organisations together with academia and key industrial stakeholders to conduct this assessment and provide strong links into many existing projects and initiatives. It will use the existing Technology Platform (Deployment Strategy & Strategic Research Agenda) and similar strategic and technical material as foundation-stones. Reference Groups will be used to engage a wide spectrum of stakeholders from industry and society. The project will deliver web-based calendars of research milestones and maps of research activity for access by the public and research community; together with reports which will assist the Commission in planning future research to support HyCom; and training manuals and dissemination directed at the wider co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Zebrafish vision in its natural context: from natural scenes through retinal and central processing to behaviour.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

All visual systems are specialised to best serve an animal’s sensory niche, yet how such specialisations are achieved through phylogenetic and developmental adaptations of the ‘common vertebrate visual system blueprint’ are poorly understood. I will study these adaptations in the visual system of zebrafish. I will use two-photon functional imaging and computational modelling to investigate how the visual system of zebrafish samples and processes behaviourally meaningful stimuli in the natural world. I will then use optogenetic manipulations while zebrafish navigate a virtual reality environment to directly probe the role of visual circuits in driving behaviour. Specifically, I will pursue four Aims:1. What is the zebrafish eye designed to see?2. How does the fish retina form feature selective output channels?3. What does the fish’s eye tell the fish’s brain?4. How does visual input to the brain lead to behaviour?Visual specialisations begin in the optics and movements of the eyes, and are subsequently deeply rooted in every step of neuronal computation. Therefore, I will study visual processing at these different organisational levels. Here, the highly ‘visual’ zebrafish present a powerful model. They (i) offer exquisite genetic tools to record and manipulate neurons, (ii) have transparent larval stages permitting optical access to the entire nervous system and (iii) there is a large array of well-studied and easily quantifiable visual behaviours. In addition, zebrafish undergo two distinct life-stages, from larva to adult - with distinct lifestyles in different visual environments and hence different feature-detection requirements. Comparison of processing strategies employed by the (a) larval and (b) adult zebrafish visual system with that of other species, including