RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Estimating a DSGE Model with Rare Disasters', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project will estimate a DSGE model with rare disasters using data from the Great Recession. Previous studies on rare disasters have been confined mainly to endowment economies. Extensions to production economies (business cycle models) have been limited. In particular, DSGE models with rare disasters have not been estimated before. The main obstacle is computational, as these models are very difficult to solve. In a recent paper with Jesus Fernandez-Villaverde we have shown that the computational problem can be resolved by a new solution method called ""Taylor Projection"", which is derived in my paper Levintal (2016). This method is able to solve large DSGE models with rare disasters in a few seconds only. This opens up the possibility of estimating rich DSGE models with rare disasters and conducting policy analysis.The project will implement the new ""Taylor Projection"" method to solve and estimate a DSGE model with rare disasters for the period of the Great Recession. This will require to extend the current solution method to allow for a ZLB constraint on the interest rate and for Markov-switching parameters, as described in the proposal. An estimated model with rare disasters may help to explain the extraordinary dynamics of the Great Recession. We conjecture that the interaction of a big macroeconomic shock (disaster shock) with the ZLB constraint played a significant role in the recession. The question is what kind of a shock generated the recession. Was it a permanent drop in long term growth, as suggested by the ""Secular Stagnation"" hypothesis of Summers (2014)? or an uncertainty shock that increased the demand for safe assets, in line with the ""Safe Assets"" view of Caballero and Farhi (2014)? or a combination of both? The proposed project will shed li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Habitat use by bats in an area of high species diversity determined by acoustic surveys and radio-tracking' under Fourth Framework.

assistant: **Concept**

Research objectives and content I will develop a method for the identification of bats by using multivariate analysis of echolocation call parameters. I will apply this method in a field survey of habitat use by bats in Campania, Italy, an area of high species diversity. I will concentrate on determining habitat use by species listed under Annex II of EC Habitat Directive, i.e. species that deserve special areas of conservation. Eight of the 13 species covered by the Directive are found in my study area. I will study habitat use of at least one species by radiotracking, and will relate this to habitat availability to determine which habitats are preferred. My major objective is to produce guidelines for the conservation of foraging areas by endangered bats. Bats are important indicator species of general habitat quality, so my results will give some measures of overall environmental standards. Training content (objective, benefit and expected impact) I will be trained in the recording and analysis of ultrasound, in the theory of acoustics, and in radiotracking techniques. I will learn about the design and implementation of sampling programmes for ecological surveys, and the analysis of habitat use data. These skills will be of wide application in conservation biology. Links with industry / industrial relevance (22) This project has no direct industrial linkage but has strong environmental relevance to conservation (see project description).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High-resolution fluorescence imaging of biomolecules' under Fifth Framework.

assistant: **Concept**

The aim of this project is to set up a novel combined wide field, confocal laser-scanning and near-field microscope for fluorescence studies of biological systems. The setup will allow to monitor the distribution of proteins in biological samples by fluorescence microscopy and to identify and localize protein interactions by means of fluorescence resonance energy transfer. Both methods will benefit substantially from the complementary techniques of confocal laser-scanning microscopy (CLSM) and scanning near-field optical microscopy (SNOM). While CLSM allows to create almost arbitrary crossections from the fluorescence distribution in a specimen, SNOM is extremely sensitive to processes on the sample surface and allows to achieve a spatial resolution of below 100 nm. The feasibility of the setup for the study of protein distributions and protein-protein interactions will be demonstrated exemplarily in an investigation of the interaction mechanisms of the HIV-1 transactivator protein Tat.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Analytical and numerical aspects of the solutions of nonlinear pde's modelling small amplitude, long water waves' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The proposed research project has as main subject the theoretical and numerical investigation of some partial differential equations (pde) and of systems of pde's, which model water wave propagation. For some of these pde's there are many analytic results, based on the inverse scattering method; for other, this method is either not applicable, or the results one obtains are not satisfactory. We want to improve the existing analytic theory, using as guideline some new results and the outcome of recent numerical experiments, and to extend the inverse spectral method in cases for which the results obtained are so far very partial. It is very important to have good numerical methods to analyze the behaviour of the solutions of these model equations? and to derive evidence of the existence of the so-called solitary wave solutions; hence we want to continue the numerical investigation, improving the existing methods and analyzing rigorously their convergence properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rural Future Networks' (RUFUS) targeting Seventh Framework.

assistant: **Abstract**

As the objectives of the CAP shift from an agricultural-centred approach to wider rural development, the idea of multifunctionality of rural areas comes into play. This in turn brings the CAP into closer association with a wide range of sectoral policy regimes: regional policy, spatial planning, environmental management; social, energy policy, and others. Sectoral regimes interact in complex ways, and with a determining effect on the sustainable development of rural areas.  RUFUS will provide policy makers and stakeholders with better theoretical and practical understandings of how CAP measures interact with other forms of public intervention in rural development; and how policy regimes can be combined to ensure more sustainable development. RUFUS will investigate how rural development policy can be targeted at the specific endogenous potential of rural regions to encourage multiple functionality which goes beyond physical landscape potentials to include social and economic activities and opportunities. An interdisciplinary methodology will build into the analysis a qualitative analysis of the social dimension and endogenous potentials, alongside economic and ecological variables. RUFUS will establish a transdisciplinary conceptual framework on policy integration and rural multifunctionality. It will create a rural typology incorporating social aspects and endogenous potentials. Scenarios of rural futures - the trajectory of policy interaction processes - will be generated. These quantitative findings will be ‘tested’ against the reality of stakeholder experiences of regional development dynamics through case studies using visualisation techniques. The relevance of the findings for other regions will be examined with the help of an expert panel. Special emphasis is give
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New electro-mechanic access system with dematerialized keys for residential market' under Horizon 2020.

assistant: **Concept**

OKIDOKEYS is a new system to unlock your home or garage door by using a smartphone or other several devices. The system will allow the user to install it in a few minutes with no need of changing the door lock.The system interacts with both an Okidokeys app-enabled smartphone (iOS and Android) as well as a number of different fobs. As an alternative to smartphones e-key, OpenWays also offers keyfobs, walletcard-tags and wristband-tags.Okidokeys has recently started a market test in the USA with very good acceptance; the objective of this project is to validate and demonstrate the new system for the European requirements that will require getting over several challenges.In the last 50 years the lock / key industry has not innovated very much:- Using metal keys could cause problems if they are lost- Metal keys are difficult to dispatch, remove or cancel.- Metal keys have limited security- Metal keys are expensive. (New securing locks have more expensive keys)Okidokeys will eliminate all those problems by the use of smart keys “installed” in a smart-phone, cell-phone, keychain, wristband, walletcard tags integrating Bluetooth 4.0, CAC (Crypto Acoustic Credentials), RFID and NFC technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of innovative assays and locally acting therapies aiming at critical kinases in hepatic and renal fibrosis' (DIALOK).

assistant: **Innovation**

The DIALOK consortium consists of 2 SMEs (situated in The Netherlands and Hungary) and 5 RTDs (situated in The Netherlands, Germany and Spain) and is dedicated to the development of innovative drugs that display a restricted action within specific target cells or organs. Such locally acting drugs will have an improved safety and efficacy, as side-effects in other tissues will be prevented. We will investigate this therapeutic strategy for kinase inhibitors, a class of drugs that has tremendous therapeutic potential but that also is associated with unacceptable side effects. Kinase inhibitors will be conjugated to two classes of carrier systems, directed to either the liver or kidney. By this, we will develop locally acting drugs for the treatment of either hepatic or renal fibrosis. We want to proof this concept in experimental animal models. An important novel aspect of the project is the linker used for coupling of the drug to the carrier. We will employ Kreatech's Universal Linker System (ULS), a novel patented drug-linker which affords straightforward coupling with most kinase inhibitors (broadly applicable) without changing the original drug structure. Another unique property of ULS is that it provides controlled release of the conjugated drug during a period of days, which is of great importance for effectiveness of the delivered drug. In parallel to development of locally acting kinase inhibitors, we will develop novel assays for detecting activation of kinases. Such assays will be of great value to the project, as it will accelerate and strengthen the validation of the kinase inhibitor-based therapeutics. Kreatech's ULS-based (fluorescent) reporter molecules are especially suitable to detect phosphorylated kinase substrates, and thus afford broadly applicable no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Harmonisation of national scales of surface colour measurements' to be submitted under Fourth Framework.

assistant: **Abstract**

Background Surface colour measurement is of importance in the production of a very wide range of manufactured goods. Industry needs to be able to measure colour within the limits of the human eye, about 0.5 CIELAB units. An earlier European intercomparison of surface colour measurements showed that 50% of colour measurements made by national standards laboratories did not agree within this limit. A reduction in uncertainties of colour measurement is needed to improve competitiveness in the trading of coloured goods. Objectives The overall objective is to reduce the errors in colour measurement so that 95% of colour measurement by the 9 participants agree to within 0.5 CIELAB units. This will be achieved through the use of a system for determining and correcting errors in colour measurement followed by an intercomparison of non fluorescent surface colour measurements. An intercomparison of fluorescent colours will also be carried out by 3 of the participants. Work Programme The coordinator has developed techniques for determining and correcting errors in colour measurements as well as a range of transfer standards for colour as part of a national programme on colour measurement. The methodology of determining and reducing colorimetric errors will be used by all participants who will then meet to refine jointly the methods to achieve harmonisation of measurements to the required level. An improvement of a factor of 4 over current levels of agreement is being sought. Ten difference steps in the technical process have been agreed. Following the determination and correction of errors each participant will measure 9 matt colour standards and 9 glossy colour standards and then calculate their colour specifications. Three participants will also measure 4 fluorescent standards b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting the Polycomb Machinery in BAP1-related Pathologies' (T-BAP), addressing dissemination and exploitation.

assistant: **Impact**

BAP1-related mutations are common genetic lesions of several cancers and neurodevelopmental disorders (NDDs). BAP1 is a deubiquitinase that removes the repressive mono-ubiquitination at histone H2AK119 (H2Aub1) deposited by the Polycomb Repressive Complex 1 (PRC1) by associating with several regulatory subunits to form the Polycomb Repressive Deubiquitinase (PR-DUB) complex.BAP1 inactivating mutations represent a hallmark in Malignant Mesothelioma (MM) for which genetic models proved its oncogenic role. Mutations further extend to several other cancers, also involving other essential PR-DUB regulatory subunits. This makes PR-DUB inactivation a major oncogenic event with ~40k new diagnosis each year between EU and US for which no precision therapeutic approaches exist. The work of my Dissect-PcG ERC project found that the major role of BAP1 is to counteract H2Aub1 diffusion across the entire chromatin. This preserves chromatin plasticity enhancing Polycomb-mediated control of transcriptional identity, which is decommissioned when BAP1 is inactivated and oncogenic H2Aub1 accumulates. We also found that diffused H2Aub1 is controlled by a specific form of PRC1 - namely PRC1.3/5 - immediately suggesting a strategy to “correct” the effects of BAP1-related mutations. Indeed, we found that specific PRC1.3/5 loss restored normal H2Aub1 levels while compromising MM cells viability, demonstrating the therapeutic potential of targeting this non-essential arm of PRC1 repressive machinery.By building a multidisciplinary team, the T-BAP project aims to develop compounds that can target PRC1.3/5 in living cells. We propose to use PRC1.3/5 structural data to identify specific binders that can function as warheads for the development of PROTAC degraders. This will generate a new class of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Power-integral points on elliptic curves' (PIP).

assistant: **Innovation**

The study of Diophantine equations is one of the oldest branches of pure mathematics. The 20th century saw Siegel’s theorem about the finitness of integral points on elliptic curves, the negative solution of Hilbert’s 10th problem, Faltings' Theorem and the proof of Fermat’s Last Theorem. In the 21st century much work has already been done to resolve extensions of Hilbert’s 10th problem and to make Faltings' theorem effective. Moreover, solving generalized Fermat equations has, for example, led to all of the perfect powers in the Fibonacci sequence being found, an unsolved problem for over 50 years. In 2006 the applicant proved that for each positive integer larger than 2, there corresponds a finite set of rational points on an elliptic curve which contains the integral points. The points in these finite sets have an important number theoretic structure and are called power-integral points. However, the proof given by the applicant uses Faltings' theorem and so gives no way to find them. Remarkably, in many cases the power-integral points can be found by solving generalized Fermat equations and by finding the perfect powers in an elliptic divisibility sequence. An elliptic divisibility sequence is in many ways an analogue of the Fibonacci sequence and its properties are receiving a lot of attention due to links with extensions of Hilbert’s 10th problem and Cryptography. It is believed that the study of these sequences combined with advances in solving Diophantine equations will achieve the objectives of this proposal. These are: to find all of the power-integral points on families of elliptic curves, and to give a quantitative bound for the number of power-integral points on an arbitrary elliptic curve.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Industrial enzynmes: Developing measurement methods for air concentrations' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

A NETWORK : 'INDUSTRIAL ENZYMES : DEVELOPING MEASUREMENT METHODS FOR AIR CONCENTRATIONS' IS PROPOSED TO BE ESTABLISHED. THIS KIND OF NETWORK WOULD SERVE AS A NEW FORUM AND CONTACT SYSTEM TO DISCUSS AND SHARE KNOWLEDGE AND INFORMATION ON ALL RELEVANT ASPECTS CONCERNING MEASUREMENT OF AIR CONCENTRATIONS OF ENZYMES. THE NETWORK WOULD ALSO BE A BASIS TO ESTABLISH CONCRETE PROJECTS BETWEEN EXPERTS IN BIOTECHNOLOGY, INDUSTRIAL HYGIENE AND OCCUPATIONAL MEDICINE, AND VARIOUS INDUSTRIES TO SOLVE THE EMERGING HEALTH PROBLEMS ASSOCIATED WITH EXPOSURE TO INDUSTRIAL ENZYMES IN PRODUCTION AND IN END USE. THIS TYPE OF FORUM DOES NOT EXIST AT PRESENT AND THE NEED OF IT HAS BEEN ACKNOWLEDGED IN ALL PARTS.THE PARTNERS OF THE NETWORK WOULD :-REPORT THEIR EXPERIENCES IN ASSESSING OR MEASURING ENZYME CONCENTRATIONS INWORKPLACES AND REPORT THE ANALYSIS AND SAMPLING METHODS-PARTICIPATE TO WORKSHOPS AND MEETINGS BETWEEN PARTNERS TO DISCUSS RELEVANT ASPECTS IN THE FIELD-PARTICIPATE TO INTERCOMPARISONS OF ENZYME DUST ANALYSIS-TAKE A RESPONSIBLE ROLE AS A PARTNER IN A FUTURE PROJECT TO DEVELOP STANDARDIZED METHODS FOR AIRBORNE ENZYME MEASUREMENT.