RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Inish Mini for On-Site Rapid Detection of Bacteria in Beer Directly from the Tap'.

assistant: **Objectives**

Cellix's goal is to launch the INISH MINI-BAR; a new low-cost, portable, rapid diagnostic device for fast and reliable detection of bacteria in beer directly from the tap enabling easy continuous monitoring of beer for contamination.  At present, breweries have no control over the quality of draught beer delivered to their customers as the existing ATP luminometer test is too time-consuming to be adopted as part of routine quality control programs.  Data now show that revenues of beer sales and profits for breweries are directly correlated to the quality of beer delivered to the customer with revenues affected by as much as 10%.  With a market value of ~€209 billion, it is easy to understand why quality control of beer at the tap is now a high priority for breweries.  Target customers are breweries such as Heineken, Carlsberg and AB InBev where the end-users are the breweries’ trade operators, whose job it is to service and clean beer taps and lines in bars and restaurants.  INISH MINI-BAR has a cost per test of <€1 vs. >€7 for the ATP luminometer test.  This can potentially save breweries ~€1.9M per region enabling them to implement a rigorous quality control program which can boost their profits.  This product development enables Cellix to open up a new market in field based testing.  Cellix’s aim is to scale up revenue to ~€28M by Year 5 of market introduction resulting in the creation of an additional 82 jobs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A new method for separation  full recovery of multilayer packaging waste to create high value materials - LAMPACK'.

assistant: **Objectives**

The food manufacturing sector has been producing multi-layered packaging since the ‘70s and are commonly comprised of layers of PET/PP/PE/PA. Over 40m tonnes of multilayered plastics are produced globally, per annum, of which the EU contributes 9.6m tonnes, with an expected growth of ~7%. However, due to the extreme difficulties in achieving effective seperation of the material into its constituent polymer components, multi-layered plastic waste is currently collected as a single waste stream & disposed of through landfill (at costs of €130 per tonne), or incinerated (~€80 per tonne). Thus, the future of multilayer packages is now a great environmental concern, with an urgent need to develop effective separation technology.Our objective is to develop an ultrasonic assisted chemo-mechanical recycling method to separate multilayered plastic packaging waste (semi-rigid trays, cups, tubs & their film-based lids), currently deemed unrecyclable, and recover polyethylene (PE) & polyethylene terepthalate (PET) individually in order to sell these end products in the EU recycling market & thereby create a new business opportunity of ~€4.8bn. Successful development of this technology will create the business opportunity to recycle this material, generating new revenues while reducing waste, landfill, energy & saving ~14.4m tonnes of CO2 emissions per annum. Our novel process will not only ensure the sustainable supply of these plastics as raw materials via environmentally friendly recycling but will also provide participating SMEs with the opportunity to derive an ongoing income. It is envisaged that the potential benefits of the LAMPACK technology would be:•Annual value for recovered PET per plant of €3.5m•Annual value for recovered PE per plant of €5.2m•Energy savings of  €1.6m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An integrated interdisciplinary approach to animal-free chemical and nanomaterial safety assessment' (2014-2020).

assistant: **Innovation**

All chemicals whether they are drugs, cosmetics, agrochemicals or others need to be tested for their safety to man and the environment. The use of whole animal studies for the prediction of adverse effects in man, is problematic due to species dependent effects, high costs and a large burden to animals in terms of numbers and suffering.  While there have been major improvements in human in vitro and in silico techniques, there is still a lack of an integrated risk assessment platform. The in3 proposal aims to significantly further the development of animal-free chemical and nanomaterial (NM) safety evaluation by creating a scientific and training program aimed at integrating human in vitro testing with computational approaches. The project will focus on human induced pluripotent stem cells (hiPSC) derived tissues, including liver, kidney, brain, lung and vasculature and to utilise mechanistic toxicology, quantitative adverse outcome pathways, biokinetics, cheminformatics and modelling approaches to derive testable prediction models. hiPSC present the major advantages provide non-cancerous derived tissues with identical genetic backgrounds. All Early Stage Researchers (ESRs) will work towards the same goal, utilising the same chemicals, donor cells, assays and software packages. All data will be centrally housed in standardised formats, appropriately annotated and linked with protocols and material information. While ESRs will hone their skills in their own field of expertise, they will also collaborate to create an in depth safety evaluation testing platform for the chosen test compounds. By interaction, problem solving, training and secondments over the three years, they will acquire a unique set of interdisciplinary skills for chemical and NM safety assessment. The pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Targeting B cell Activation driven by Natural Killer cells' (TABANK).

assistant: **Concept**

Autoimmune diseases affect nearly 4% of the world’s population and can be life-threatening. Among them, primary Sjögren Syndrome (pSS) is the most common systemic autoimmune disease. Unfortunately, to date, treatments are focusing on relieving symptoms. It is of public relevance to find potential new biomarkers for treatments. B cells are one key player in pSS and promising drugs targeting B cell activation are currently under phase 3 clinical trials. Restraining B cell hyperactivity is central to treating pSS permanently. Hence, instead of targeting B cell activation, pSS treatments would also benefit from targeting signals or interactions leading to B cell activation. The TABANK project aims to address this hypothesis by using cutting-edge technologies (high-parameter flow cytometry, single-cell sequencing technologies and unsupervised analysis) to interrogate the immune network in the circulation of pSS donors as well as in the inflamed environment of impaired salivary glands. This overarching goal will be achieved by (i) Compiling a comprehensive database of immune cell profiles in pSS using both single-cell sequencing and high-parameter mass and flow cytometry; (ii) Determining potential interactions of immune cells leading to B cell activation using a novel computational approach; and (iii) Validating these interactions using ex vivo culture. TABANK will be conducted at the Lymphocytes B, Autoimmunity and Immunotherapies center, Université of Brest Occidentale a leading research institution in the study of immunotherapies for B cell diseases. This project will be supervised by two leading experts in autoimmune diseases and B cell biology. This unique synergy, in addition the researcher’s own expertise in examining immune responses in human tissues, particularly or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhanced Human Robot cooperation in Cabin Assembly tasks' (EURECA).

assistant: **Innovation**

The EURECA project framework is dedicated to innovate the assembly of aircraft interiors using advanced human-robot collaborative solutions. A pool of devices/frameworks will be deployed for teaming up with human operators in a human-centered assistive environment, always ensuring safety requirements. Solutions are peculiarly designed for addressing both the working conditions and the management of the cabin-cargo installation process. EURECA aims at providing the following technologies:1. Lightweight Mobile Arm (LMA), an actuated moble platform equipped by a lightweight manipulator, will assist the assembly of light components. The LMA will perform autonomous tasks for assembly light and small components and it will cooperate with humans in handling and assemblying large, light and flexible compoents, navigating autonomously in the cabin and supplying the different parts by a passive trolley (transporter).2. Wearable upper arms exoskeleton will be used to assist the human operator in handling and assembling of heavy parts. The exoskeleton will improve the human ergonomics in handling heavy objects, allowing the execution of tasks where two or more people are necessary having a fast attach/detach interface.3. Continuous update and adaptation of a map of the aircraft’s cabin, including permanent/temporary obstacles (seats, exoskeleton structure, human operator moving, etc.) by RGB-D camera sensors mounted on the LMA. 4. A software platform, called Application Assistant, will enhance human-robot cooperation in all process  phases, supporting the generation of programs and the issuing of commands/requests by the users. The Application Assistant will be a layered architecture that will provide the users with different services in creating, scheduling and executing applicati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From Gene Regulatory Networks to Specification, Differentiation and Morphogenesis in the sea urchin embryo' (ECT-SPEC-DIFF-MORPH), addressing dissemination and exploitation.

assistant: **Impact**

A fundamental challenge in developmental biology is to understand how regulatory networks transform regulatory information into cell fate specification and differentiation. Addressing this challenge requires a comprehensive analysis of the regulatory connections between the transcription factors present in a cell and their regulatory and structural targets through developmental time. The sea urchin aboral ectoderm provides an excellent system to dissect these connections due to its accessibility to quantitative expression studies and the multiple developmental programs executed in this territory. One of these programs drives the differentiation of the entire aboral ectoderm into squamous epithelium and represses neural fate, while other programs define regulatory sub-domains within the aboral ectoderm important to normal morphogenesis of other embryonic territories. These programs depend strongly on the BMP pathway, a highly conserved regulator of ecotdermal patterning. Here we propose to identify the downstream targets of the aboral ectoderm regulatory network and to construct a mechanistic model of the aboral ectoderm specification and differentiation. We will conduct a genome-wide identification of (1) cis-regulatory elements that the aboral ectoderm transcription factors bind to (2) genes that respond to perturbation of the aboral ectoderm transcription factors. The function of identified cis-regulatory elements will be tested using a new high-throughput technology. The expression of key target genes will be perturbed and their effect on the aboral ectoderm morphology and embryogenesis will be studied. Based on this analysis we will construct a mathematical model that simulates the dynamic function of the aboral ectoderm regulatory network. Thus, this project will p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'LEAPS pilot to foster open innovation for accelerator-based light sources in Europe'.

assistant: **Concept**

The European synchrotron radiation sources and free electron lasers serve a broad scientific community with more than 24000 users and play a vital role in most research fields from basic science in physics, chemistry and biology to applied areas in health, engineering, environment, cultural heritage and high-impact industrial applications. Rising international competition requires the European facilities to coordinate and combine complementary strengths and capabilities. Established in 2017, the League of European Accelerator-Based Photon Sources (LEAPS) seeks to realise synergies across Europe’s light sources. The increasing complexity of technology and a shorter life cycle require the photon sources to open up innovation to their partner facilities, users and industrial suppliers to promote creativity, novelty and resource efficiency. The LEAPS-INNOV pilot project will contribute to solving key technological challenges for the light sources, over 50 facilities in Europe and worldwide, and in particular will support their newest generation - diffraction-limited storage rings and X-ray FELs. It will kick-start the implementation of the LEAPS Technology Roadmap and, at the same time, will enhance partnership with industry through open innovation by offering joint technological developments and advanced research capabilities for industry as collaborators, suppliers and users.Six technology work packages (WP) form the heart of LEAPS-INNOV, based on their potential for co-innovation and their ability to enhance European leadership of both, LEAPS facilities and industry. They integrate 50-some companies, are supported by an industry networking WP and complemented by pilot activities towards co-creation with the Horizon Europe clusters. In the context of open innovation, LEAP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Atomic Gyroscope for Enhanced Navigation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Aircraft navigation and safety in the absence of GPS/Galileo signals can be improved by higher performances Inertial Measurement Units (IMU) and thus by higher performances gyroscopes.The “Atomic Gyroscope for Enhanced Navigation (AGEN)” project aims at showing the feasibility of the development of such an inertial grade gyroscope for aircraft navigation and delivering higher performances than Ring Laser Gyroscopes while having small dimensions and power consumption. Atom (atomic) gyroscopes hold the promise of reaching even better performances, but their state of development is presently in the “research” stage and user’s requirements in terms of size, power consumption, cost and performances will be analyzed and targeted.Such a development may open up new application fields such as unmanned commercial flight, enhanced navigation for UAVs, enhanced marine, sub-marine and Unmanned Surface Vehicle navigation.A conceptual design will be performed, allowing the trade-off between various concepts. Laboratory tests will be restrained to validating the gas cell, the heart of an atomic gyroscope, showing the feasibility of such a concept.This development will bring redundancy and will enhance the robustness of guiding systems relying on Galileo..Finally, an assessment and a roadmap of the future development steps will be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Accelerating investments and partnerships for EIC High Growth deep tech beneficiaries' (2014-2020).

assistant: **Concept**

Only 5% of European start-ups scale-up and pursue the position of world tech leaders. The growth barriers are high for truly high-risk deep-tech innovators, the main target of EIC instruments. Deep-tech innovators struggle to get required capital at the different stages of their lifecycle.The EIC-ScalingUP is set to create a blueprint for the EIC deep-tech growth companies to successfully scale and accelerate their investments and partnerships. It will identify, engage, select and feature 50 EIC companies with ability to become world-scale companies, select up to 30 and guide their growth plan and ambitions and create the blueprint of the tailored ScalingUP services. The execution of the defined blueprint will support the growth and funding of the 30 companies and foster exposure and connections with target stakeholders and networks with the aim to impact the key growth fundamentals and to lead to a successful Series B/C round or acquisition value, thus validating the EIC-ScalingUP blueprint.It is expected that 500+ Euro Million will be raised by the supported companies and inspirational success stories of EIC deep-tech companies will be broadly promoted to establish the EIC-ScalingUP as a credential of honour among Investment & Innovation communities.All activities in the EIC-ScalingUP are carried out by a consortium of 4 partners with complementary expertise: Coordinator Tech Tour (Networking & matchmaking between innovative SMEs; investors, corporates and advisors), Bpifrance (the French public investment bank assists businesses across stages and sectors and finances them from the seed phase to transfer to stocks exchange listing through loans, guarantees and equity), Boston Consulting Group (a global management consulting company with a deep understanding of the Dee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Revealing cellular behavior with single-cell multi-omics' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Chemical reactions govern cellular behavior, and are revealed by analysis of small molecules involved in intracellular metabolism. Individual cells in biological systems continuously adapt to improve survival and biological function, making them chemically and behaviorally heterogeneous. Unraveling this heterogeneity is essential to realize the correlation to disease state and health, but it is masked in bulk analyses of millions of cells. I propose to develop a groundbreaking analytical approach for multi-omics of living individual cells to reveal variability in cellular behavior. This will be achieved by coupling a microfluidic device that enables controlled chemical exposure of a cell, to an efficient ionization probe for on-line time-resolved mass spectrometric measurements. By measuring the dynamics of each cell’s metabolome, lipidome, and secretome, novel insights into heterogeneity in intracellular activities will be gained. In addition, the level of heterogeneity will be uncovered through correlation with the cell’s transcriptome.A special emphasis will be given to characterize individual β-cells that are key regulators of blood glucose by insulin secretion and whose dysfunction leads to type 2 diabetes. The behavior of individual β-cells is heterogeneous and ranges from complete failure to secrete insulin to compensating with increased secretion. I will use the single-cell multi-omics approach to test the hypothesis that intracellular metabolism is the key to β-cell dysfunction, and analyze healthy and diabetic β-cells upon chemical exposure to establish i) their metabolic heterogeneity and differences, ii) variations and temporal dynamics in their metabolic behavior and iii) metabolic roadblocks that correlate with β-cell dysfunction.The single-cell multi-omic