RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Development and implementation of new conceptual density functional theory reactivity indexes and its applications to zeolites'.

assistant: **Innovation**

The goal of this project is to develop and implement a new methodology in the framework of the conceptual density functional theory (DFT) and its application to chemical reactivity, with special interest to zeolites. The central quantities of conceptual DFT are the response functions. A fundamental problem arises implementing these functions, particularly the question whether energy is differentiable with respect to the number of electrons.An alternative way to evaluate these properties is using analytical, approximate expressions of the Hohenberg-Kohn universal density functional and the hardness kernel. This method may be the future, but the accurate determination of the hardness kernel remains a problem. This project intends to be the first pioneer attempt to look for a universal density functional, yielding the cheapest and more accurate values of local hardness and global hardness. But all these developments of conceptual DFT will be only meaningful, if they can explain or predict experimental results. Thu s, one of the aims of this proposal is the application of this methodology to improve the understanding of zeolite catalysis, which results essential in Materials Science.The chemisorption of CO2, transforming into carbonate species upon reaction with lattice oxygens, is a probe for basicity. The DFT-based reactivity indexes are a useful tool to rationalize this issue. The present proposal will improve the European research community in three aspects. First of all, the creation of the first universal conceptual DFT program, that will become a useful tool to predict the chemical reactivity in many areas such as Organic and Inorganic Chemistry (thematic priority 3). Secondly, it will lead to a better understanding of the basicity of zeolites and the chemisorption o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Estimation of the upper ocean 3D velocities from remotely sensed sea surface temperature' to be submitted under Sixth Framework.

assistant: **Abstract**

Surface ocean horizontal velocities are regularly estimated from altimetric measurements. However, these velocities are of relatively low spatial resolution. Infra-red sensors providing Sea Surface Temperature (SST) have considerably higher resolutions and have been already considered to gain in resolution with Maximum Cross Correlation techniques.However, these methods require the availability of a time-series of cloud-free SST images, which is very difficult to obtain. Recently, researchers from the host institution (Ifremer) have proposed a new methodology, based on the Surface Quasigeostrophic theory. The proposed method now enables the estimation of surface currents from a single Sea Surface Temperature (SST) image.According to this new theoretical framework, estimations of subsurface horizontal and vertical velocities in the first 500 meters of the upper ocean are possible. The main idea of this project is to thoroughly investigate the applicability of this theoretical framework to real remotely sense d data. To this end, first, the method will be thoroughly tested on the recent numerical simulations done with the Earth Simulator supercomputer (Japan) by the host institution.These numerical simulations provides, for the first time, a benchmark for the infra-read SST (a domain of 1000x2000 km at 1 km of spatial resolution). Then, the method will be applied to infra-red and microwave SST. Results will be tested with available in situ measurements and altimetry.The success of this proposal is not only a key opportunity to complement researcher's training with the state of the art in geophysical fluid dynamics and numerical simulations but also it may represent a milestone in the operational use of oceanographic satellites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards the analysis of energy conversion materials at the atomic scale' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The properties of interest of functional materials are strongly correlated to their intimate structure down to the nanometre scale. Designing novel, more efficient materials requires a control over their structure and chemistry at the very same scale. One of the challenges of the 21st century is to tailor energy conversion materials enabling a more efficient harvesting of the energy of the Sun. Thermoelectric power generation is a well-known effect through which thermal energy (heat) is directly converted into electricity without any intermediate working fluid or any moving parts. These materials are generally highly doped, nanostructured materials. Although very promising, the structure – activity relationship in this class of materials is still really unclear, due to a lack of nano-scale characterisation. I aim here to get trained on several analytical techniques, including dual beam Scanning Electron Microscope/Focused-Ion-Beam, Atom Probe Tomography (APT), and various declinations of Transmission Electron Microscopy. I will also acquire a better understanding on the functioning of the laser-assisted APT, which will enable me to start a collaborative work to correct the intrinsic aberrations of the technique. Drawing on the experience of the host group in conducting a complete materials science study, I will improve my skills in this field, and acquire methods, protocols and knowledge enabling me to solve materials science problems. This training will permit to perform at the same time an in-depth study of the multi-scale characterisation of the structure and chemistry of these materials, aiming to improve the design and efficiency of thermoelectric devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The structure of innovation and economic performance indicators' (SIEPI).

assistant: **Innovation**

This project will develop a new generation of indicators of innovation, capable to describe the variety of efforts devoted to technological change and the resulting economic performance, in terms of output and productivity growth, employment patterns and international production. These indicators will be developed at the sect oral level for both manufacturing and service industries, building on the data of the Community Innovation Survey II made available by national statistical sources. The project will make it possible to produce a detailed, systematic, comprehensive and openly accessible database linking innovation indicators to a large set of variables on economic performance. It will lead to detailed analyses of such data and to the development, testing and adoption of a new set of advanced innovation and performance indicators, paying special attention to the needs of European and national policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring Chemical Biodiversity with Innovative Approaches for Fighting Chagas and Leismaniasis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ChemBioFight project aims towards the exploration of natural resources to the discovery of bioactive therapeutic molecules against leishmania and Chagas disease. This will be accomplished through the establishment of an extended scientific network between European and South American research entities. Already assembled, highly diverse chemical libraries will be employed for the determination of active natural scaffolds leading to the focused collection of biomaterial (plants, marine organisms, fungi, endophytes) from local diversity hot-spots. Automated, high throughput and advanced techniques will be incorporated for the extraction process as well as the isolation and identification of natural products. Sophisticated approaches as metabolomics and chemical profiling will contribute to the discovery of novel active compounds and will be used to conduct dereplication procedures. Semi-synthetic derivatives of lead compounds will be also produced aiming to the optimization of favorable biological properties via medicinal chemistry aspects. In every step of the proposed work flow, the obtained samples (extracts, isolated compounds, synthetic derivatives) will be evaluated in vitro and/or in vivo for their antileishmanial and antitrypanosomal activity. Within the aforementioned context, an extensive net of secondements, both with educational and experimental attributes, will be established. Core scientific knowledge is expected to be produced and exchanged, with the prospect of creating partnerships with future scientific potential. All partners will participate in the dissemination procedure through teaching activities, workshops and international conferences, leading overall to mutual transfer of know-how. Finally, all procedures will be effectively monitored from a ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'How to evolve without centromeres: meiotic recombination dynamics in holocentric plants' under Horizon Europe.

assistant: **Concept**

Centromeres strongly affect genomic architecture and meiotic recombination distribution and also play a key role in constraining karyotype evolution. The recombination landscape is also heavily influenced by chromosome number and structure (i.e., karyotypes), as at least one crossover per chromosome (and rarely more than three) occurs in most species, making chromosome number the primary driver of recombination frequency. In addition, centromeres inhibit recombination, and therefore crossovers tend to occur mostly at chromosome ends.However, several unrelated eukaryotic lineages do not have centromeres, or at least, not conventional ones. Such is the case for plants with holocentric chromosomes, where hundreds of small centromere-like units are evenly distributed across the length of the chromosome. Notably, holocentricity has evolved repeatedly across the tree of life and at least four times during plant evolution.Holocentric plant species offer a unique opportunity to study the plasticity of meiotic recombination control. These species have lost typical centromeres, making them ideal for investigating how the recombination landscape was reshaped after the transition to holocentricity. Moreover, holocentricity unleashes changes in the karyotype, offering the possibility to analyze the effects of chromosome breaks and fusions on recombination frequency and distribution.The HoloRECOMB project aims are as follows:I.Analyze how transitions to holocentricity affect meiotic recombination dynamics in different holocentric plant lineages.II.Explore the effect of chromosome breaks and fusions on crossover number and distribution.III.Examine whether the crossover regulation in holocentric plants acts in a similar manner as in monocentric ones.Understanding how holocentricity aff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Philosophical Foundations of Criminal Law in the Age of Robots' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Robots are made to serve humans in carrying out tasks that are hard, dangerous, or repetitive, as well as for entertainment. Despite their (generally) benign objectives, robots may promote harmful outcomes that are under the radar of criminal law. One of the main aims of criminal law is to stabilize society. If something wrong is done, the law provides ways of responding to it. The situation could be complicated by the wider application of robots in social life: not only do they disrupt the practice of law, they also have the potential to challenge its very foundations. The main aim of the ROBOCRIM project is to build a philosophical ground for criminal law that accommodates robots. I will ask, “How can the philosophical foundations of criminal law be reconstructed to accommodate robots?” instead of, “How to accommodate robots into criminal law?” which is the usual formulation. This shifts the approach to the discussion on robots and their alignment with law and social life. The project will be conducted within three interrelated work streams. The first stream will be devoted to robots and their status from the perspective of the philosophy of criminal law. The second stream will focus on the foundation of a new account of criminal law, which I call the “phenomenological account”. The emphasis in the third stream will be on building models of institutions that accommodate robots within criminal law, to be tested using experimental methods. These new models of criminal response to crimes committed by robots treat robots as initiators of events that require a response from criminal law rather than as individual agents that could be responsible for their actions. This, combined with a novel account of criminal law, makes the project ground-breaking. It is interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sensory Feedback for Improved Prosthesis Control' (SENSPRO).

assistant: **Innovation**

Functional substitution of a lost limb is necessary for persons with an amputation to perform daily life explorations and manipulations in their environment. In the case of a hand loss, affective reasons gain importance as amputees often indicate the desire to feel the warmth of a loved one’s touch. These considerations provide two key characteristics of successful prosthetics: (1) intuitive control of prostheses and (2) providing physiologically appropriate feedback to the user. Although there has been significant progress on the prosthesis control and sensory feedback, the ability to supply physiologically appropriate proprioceptive feedback remains elusive. This project seeks for sensory feedback for improved prosthesis control. First, relative contributions of feedback modalities (vision, proprioception and artificial proprioception) on coordinated manipulations will be investigated. Then, based on these results, new sensory feedback systems will be developed for persons with an upper-limb amputation.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sudden Cardiac Death and Electrical Dyssynchrony Mediated by Purkinje-His Dysfunctional Activity'.

assistant: **Innovation**

Cardiovascular disease is the first cause of mortality in the whole world (WHO 2008), responsible for 700000 deaths each year in Europe; a huge burden on healtcare. Half of this mortality is due to heart failure (HF), which can be caused or further aggravated by electrical dyssynchrony. The other half of cardiac mortality occurs suddenly, essentially due to ventricular tachyarrhythmias.The main objectives of SYMPHONY are (i) to advance our fundamental understanding in the mechanisms underlying SCD and electrical dyssynchrony in HF, with a strong focus on the specialized ventricular conduction network, and (ii) to improve current preventive, diagnostic and treatment methods for these life-threatening cardiac electrical disorders.SYMPHONY is a multidisciplinary project that will benefit from a wide array of state-of-the-art methodologies and expertise, both in fundamental and clinical sciences. A large mammalian species, the sheep, will be used for a detailed characterization of the properties of the conduction network in health and disease. Importantly, a limited number of explanted human hearts will be available on which all these techniques will equally be applicable. From our clinical work, SYMPHONY will benefit from cutting edge tools in epicardial and catheter mapping allowing simultaneous mapping of the Purkinje system and ventricular substrate. The gathered data will be fed into large-scale computer models that will allow personalized investigations into the mechanisms of SCD and electrical dyssynchrony.SYMPHONY has a significant potential for industrial valorisation and is likely to introduce new targets for interventions, and new methods for risk stratification and prevention. Therefore we can affirm that this unprecedented, comprehensive and translational proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthetic and structural biology of Rab GTPase networks' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Eukaryotic cells are characterized by their compartmentalization into hundreds of different membrane-bound organelles with unique biochemical identities. Small GTPases of the Rab family play a central role in this organization, but how they are able to generate spatiotemporal order in the complex cellular environment is currently not known. Most previous studies on Rab GTPases have either relied on describing their behavior in living cells or in highly reductionist biochemical assays. However, neither of these two approaches can explain the dynamic activity patterns of Rab GTPases associated with their cellular functions. It has become clear that Rab GTPases are controlled in sophisticated regulatory networks with emergent, self-organizing properties. To obtain a mechanistic understanding of these Rab GTPase systems, new experimental assays are now required. In this proposal, we will use a “bottom-up” synthetic biology approach to rebuild the biochemical networks of Rab GTPases from purified components and demonstrate their self-organization into spatiotemporal activity patterns in vitro. We will combine these reconstitution experiments with cryo-electron microscopy to elucidate the structures of membrane-recruited Rab GTPase regulators. Finally, we will use microfabrication and laser lithography to prepare a mimic for the compartmentalized cell and find out how Rab GTPase signaling systems sense and process preexisting geometric and biochemical cues as in the living cell. This project will provide novel, quantitative information from different scales, from the emergent ensemble behavior down to the molecular structure of protein complexes. Together, this data will reveal how signaling systems of Rab GTPases control membrane identities in space and time, thereby improvi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MULTI-STRING CASING CUTTING SYSTEM' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The aim is to demonstrate, under platform decommissioning conditions, that 100 percent cuts of multi-string casings can be achieved under the worst conditions of tubing eccentricity. Cutting to be achieved for multi-strings with the minimum inside casing diameter of 7 inches and the maximum outside diameter of 30 inches.The main outcome of the project will be to demonstrate:1. A powerful abrasive water jet system based on direct injection of abrasive (DIAJET) that is capable of reliable operation offshore.2. A manipulation system that can operate within 7 inch casing and cut multi-string piles below seabed level.3. Successful cutting of multi-string piles that represent the most arduous platform decommissioning situations likely to be encountered in the North Sea.Over the forth six-month period of this project, the following progress has been made:- The 700 bar continuous circuit testing has been completed and reported- Jet pump transfer efficiency is required at 200%. Results at 700 bar show that approximately 250% transfer efficiency is achieved whilst the abrasive concentration is 15%.- Testing of the load cells showed that they did not accurately measure the weight of abrasive in the vessels but did regognise the change in level of abrasive.- The load cells used are rated for the 1400 bar system and on the final system the load cells will give sufficient data to allow for more accurate readings on vessel abrasive levels.- Following modifications described in the 18 month report the 1400 bar valve has undergone further trials and to date has completed 5000 cycles without failure. This is well in excess of requirements.Design of the 1400 bar system, utilising the jet pump transfer circuit, is now ready to commence. However before this can be started the sizing of the