RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Directed evolution of a synthetic episome based on hexitol nucleic acids (HNA)'.

assistant: **Innovation**

A long term goal of synthetic biology is the assembly of a cell from its individual components. A genetic element based on synthetic nucleic acids capable of stable propagation, a synthetic episome, is the minimal genetic element required for the systematic development of all cellular components of a synthetic organism based on artificial nucleic acids. Recent progress in DNA polymerase engineering has successfully isolated variants with expanded substrate spectra capable of efficiently synthesising hexitol nucleic acids (HNA) from DNA templates, and capable of synthesising DNA from HNA templates. Together, they demonstrate that HNA can serve as a genetic material. However, the unavoidable DNA intermediate in HNA replication and their limited processivity greatly limit the potential of these polymerases for the development of an HNA episome.To establish an HNA episome, processive HNA-directed HNA polymerases as well as accessory proteins to support episome maintenance and replication are required. The bacteriophage phi29 requires only four proteins (including polymerase, terminal protein, single-stranded and double-stranded DNA binding proteins) and two DNA elements (origin of replication and high affinity sites for its double-stranded DNA binding protein) to replicate and maintain its linear genome, making it a suitable starting point for the development of an HNA episome.We propose to develop novel in vitro selection methodologies that will allow the directed evolution of a minimal HNA episome based on the phi29 system – including the isolation of an HNA-dependent HNA polymerase, a modified terminal protein and single-stranded as well as double-stranded HNA binding proteins. In addition to being a landmark result in synthetic biology, such HNA episome can form the bas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A structure-function analysis to discover how receptor conformations and interactions determine semaphorin-neuropilin-plexin signalling outputs.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

During the development of a multicellular organism cell guidance proteins interact with their cognate cell surface receptors to guide cells to their correct location. Such functions continue to be essential in the adult to maintain tissue homeostasis. Semaphorins use plexins as their main receptors for signalling and the semaphorin and plexin families together constitute one of the largest and functionally diverse of the cell guidance systems in vertebrates. We have gained some insight into the architecture and interactions which trigger semaphorin-plexin signalling, but fundamental questions remain and some of the most puzzling, and of potential clinical importance, concern the mechanisms of action of the secreted class 3 semaphorins (Sema3s), and their (co-)receptors. Neuropilin co-receptors play pivotal roles for Sema3 function and have been implicated in context dependent switching of cell guidance signalling outputs. There is an urgent need for information on molecular mechanism to underpin the design and interpretation of studies into biological function and clinical pathology. To advance the field we will combine structural biology and cellular imaging based approaches with functional studies (in house and in collaboration).The research plan is sub-divided into three inter-related sections that aim to discover:1. The structural determinants and mechanisms of action by which class 3 semaphorins exert differing effects on signalling.2. The conformational state of the plexin ectodomain in different contexts and its contribution to signal outcome.3. The mechanisms by which neuropilin binding can switch the outcomes of plexin signalling.Molecular level answers to the questions posed by semaphorin-neuropilin-plexin signalling will take us beyond the current state of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sensing ENdometriosiS On Portable Auxiliary Devices' (SENSOPAD), addressing dissemination and exploitation.

assistant: **Impact**

SENSOPAD initiative heralds a transformative era in women's health by addressing the longstanding challenges posed by Endometriosis (ED). ED's early detection is often underdiagnosed due to its asymptomatic nature, pivotal for improved health outcomes and reduced healthcare costs. SENSOPAD introduces two pioneering ED sensing systems: sensoPAD, seamlessly integrated into sanitary pads, and sensoMFgFET, a portable Point-of-Care (POC) device.SensoPAD comprises three Biological Processing Units (BPU) - BPU-1, BPU-2, and BPU-3 - ensuring continuous monitoring. BPU-1 combines an electrochemical sensor with RFID, while BPU-2 merges a chemical-based fuel cell with an electrochromic cell. BPU-3, an energetically autonomous unit, synergizes BPU-1 and BPU-2 capabilities for seamless monitoring. SensoMFgFET, a POC device, utilizes microfluidic systems and bio-conjugated gFET with RFID functionality, capturing specific DNA SNPs from the menstrual fluid as early ED indicators. Both devices are complemented by a user-friendly mobile application enabling real-time data acquisition and analysis. An advanced cloud platform integrated with AI enhances diagnostic accuracy. This innovative approach shifts the paradigm in ED detection, empowering women, clinicians, and healthcare systems.  SensoPAD detects biomarkers, providing insights during menstrual cycles. If concerns arise during its use, users transition to sensoMFgFET at clinical points, combining at-home convenience with clinical precision. SENSOPAD aims to reduce ED diagnosis time from eight years to days, enabling early treatment, preventing symptom deterioration, optimizing infertility care, and streamlining healthcare journeys. Integrating SENSOPADs with a mobile app and AI-enriched cloud platform ensures accurate, cost-effecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Precision biomarker based on digital pathology and artificial intelligence to guide fast and cost-effective personalized treatment decision support for colorectal cancer patients' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

There is consensus in the oncology community that there is a large need for personalized cancer treatment decisions as patients suffer from large-scale overtreatment. Up to 90% of patients receiving adjuvant chemotherapy have no effect, many suffer severe side effects. DoMore Diagnostics (DoMore Dx) delivers pioneering diagnostics software that enables personalized cancer treatment in a simple and cost-efficient way. We provide deep learning algorithms applied to cancer tissue whole slide images (WSI) in the adjuvant chemotherapy setting. With end-to-end deep learning we have taken a completely new approach to this challenge. Our test can be run in local labs with digital pathology equipment and does not consume any tissue. DoMore Dx is personalized medicine made simple.In CRC, our test can stratify patients into low, intermediate, or high risk with a hazard ratio >10. This information can be used to take up to 250,000 patients out of chemotherapy and save 4 billion EUR globally every year.


**Keywords:** Colorectal cancer; Medical Imagining; Histology; Machine Learning; Prognosis; Prediction; Therapy guidance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Seismic performance and residual displacements of reinforced concrete walls detailed with iron-based shape memory alloys' (SMA-RC-Walls) targeting Horizon Europe.

assistant: **Abstract**

The current seismic design philosophy of reinforced concrete (RC) walls typically requires large inelastic strains and damage to accumulate in a plastic hinge region, which can result in post-event residual building displacements. Often, the residual displacements will be in such excess that the building is required to be demolished. This costly but expected performance level (i.e., no collapse, life safe) is currently under scrutiny and instead a serviceable structure with limited damage is warranted by the building owners and engineers in the event of a large earthquake. To achieve these targets, engineers will have to implement better structural technologies. Shape memory alloys (SMAs) have the capability to recover displacements upon removal of stress and dissipate energy through hysteretic damping. This project investigates the efficacy of iron-based SMA bars as a substitute material for typical steel in the boundary regions of RC walls to reduce residual displacements and improve the seismic performance. This interdisciplinary research will be carried out at the Universite catholique de Louvain, Belgium, under the supervision of Professor Joao Almeida in the Institute of Mechanics, Materials and Civil Engineering. An extensive experimental program is proposed, which subjects large-scale RC wall specimens detailed with iron-based SMA bars to quasi-static reverse cyclic in-plane loading. The experimental results will be used to validate state-of-the-art finite element models to undertake an extensive parametric study. Recommendations will be provided on limiting the residual displacement of RC wall buildings, which is aligned with the next generation of Eurocode 8 guidelines. The outcomes of this proposed research have the potential to achieve a more robust building
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of the dynamic mechanisms regulating the targeting and clustering of sodium and potassium channels in neurons', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The electrical excitability is a fundamental property of neurons. Diversity in intrinsic neuronal excitability is generated by the variable expression, subcellular localization, and function of a complex repertoire of ion channels. Dynamic regulation of intrinsic excitability can further alter the behavior of neurons and confer plasticity to neuronal signaling. Aberrant expression, localization, and function of ion channels can result in channel-based pathophysiologies. One of the challenging questions is to understand how neurons regulate the expression and localization of ion channels. The Axon Inital Segment (AIS) and the nodes of Ranvier are key sub-compartments that generate and conduct the action potentials along the axon. The voltage-dependent sodium (Nav) and potassium (Kv) channels are critically concentrated at the AIS and nodes of Ranvier to ensure proper axon potential propagation. Despite the central role of these channels in excitability, the molecular and cellular determinants governing their appropriate targeting and membrane organization are just beginning to emerge. An intricate assembly of adhesion molecules and cytoskeletal scaffold proteins hold Nav and Kv channels in place. However, how such a complex is dynamically regulated is still largely unknown. We recently identified two new processes based on phosphorylation of Nav and Kv complexes by two kinases, casein kinase 2 (CK2) and cyclin-dependant kinase (Cdks). The phosphorylation/dephosphorylation modifications of these channels modify indeed their localization at the AIS. Here, I propose to analyze, using a multidisciplinary approach, the respective role of CK2 and Cdks signaling pathways on dynamic targeting/assembly of Nav1 and Kv1 channels at the AIS and in the node of Ranvier. The end-result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Unique breakthrough ex vivo human skin model to predict efficacy and toxicity of subcutaneous drugs'.

assistant: **Innovation**

Subcutaneous injection drug market is highly increasing (CAGR of 7%) and is view as a viable alternative route for parenteral drug administration because it enables at-home injection, improves quality of life and reduces health care costs. However, the absence of accurate biological model to predict the effect of drug injection in the subcutaneous tissue limits their development. That issue leads to 88% of drug attrition causing a loss of more than €1B per developed drug and a sharp decrease of patient security during clinical trials.HypoSkin is the first and unique in vitro standardized and ready-to-use testing kit containing living ex vivo human skin biopsies with subcutaneous fat, allowing pharmaceuticals to highly reliably predict local human’s response to the injection of a drug or a medical device. This disruptive innovation permits Hyposkin’s customers to save time and money (10 times faster and 5 times cheaper than animal experiment, confirmed in the on-going payed pilot test) as well as secure the development of their products before clinical trials. HypoSkin will become worldwide reference method to replace inadequate animal testing currently used today. HypoSkin model is developed by Genoskin an innovative French company, founded in 2011 as a spin-off of the French National Center for Scientific Research and the Paul Sabatier University in Toulouse. Genoskin provides other human-skin alternative models to pharmaceuticals companies all over the world leading to sales of €700K in 2017.The SME Instrument project will allow the company to improve, qualify and industrialise HypoSkin. To accomplish this goal Genoskin will complete a feasibility study to further analyse risks and cost of scale-up, the European regulatory framework and will deepen and sharpen the glo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Artificial INtelligence-based Interactive Microtonal Compositional Assistant'.

assistant: **Concept**

The ANIMA (Artificial INtelligence-based Interactive Microtonal Compositional Assistant) project addresses the limitations of current AI-driven music generation systems by shifting the focus toward human-centered creativity. Unlike platforms that risk homogenizing musical output, ANIMA empowers users to engage deeply with novel harmonic structures, specifically microtonal harmony. This project explores music systems beyond traditional Western 12-tone equal temperament (12-TET), embracing 31-tone and 53-tone equal temperaments to unlock new musical possibilities and enhance compositional diversity.The project is rooted in European academic perspectives and draws on computational modeling and machine learning to support rather than replace human agency. It builds on the ongoing work at institutions such as the MUSAiC (ERC) project, the Music Technology Group at Universitat Pompeu Fabra, and the Algomus lab at Université de Lille. ANIMA allows composers to explore expanded harmonic and melodic vocabularies with real-time interactive interfaces and data visualization to navigate microtonal harmonic spaces.ANIMA aims to establish a microtonal music corpus and develop computational models integrating advanced music theory with machine learning techniques. This paradigm shift contributes to a broader understanding of harmony, promotes cultural diversity, and supports the preservation of non-Western musical traditions. The open-source framework also paves the way for its integration into music education, musicology, and digital humanities, with potential commercialization through collaborations with industry partners.In summary, ANIMA is poised to revolutionize AI-assisted music composition by offering innovative tools for microtonal music exploration while maintaining the intr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Black holes altering galaxy evolution: how to find them?' in the context of a Seventh Framework call.

assistant: **Objectives**

A major challenge in our understanding of the Universe is that cosmological simulations of galaxy formation and evolution fail to reproduce the mass distribution of present-day galaxies, producing more massive galaxies than those observed. Black holes are claimed capable of solving the problem by accelerating gas and expelling it out of galaxies through radiation pressure, plasma jets, or accretion-disk winds. Recent observations confirmed the existence of outflows carrying more molecular gas than the gas that forms new stars in ~10 nearby galaxies. The phenomenon's frequency is nonetheless unclear. Our goal is to determine, for the first time, how frequently do black holes in the local Universe drive fast, massive outflows that can suppress star formation and affect the evolution of their galaxies. To discover new outflows, we will (a) determine the properties of the outflowing gas in nearby prototype galaxies observed with the Herschel Space Telescope, Institut de Radio-Astronomie Millimetrique Interferometer, Sub-Millimeter Array, and Very Large Telescope, (b) run magnetohydrodynamic simulations to identify the most likely driving mechanism and to quantify the amount by which star formation is suppressed/enhanced in each case, and (c) initiate a large-scale query for new molecular gas outflows in the archive of the largest infrared space mission, Herschel. Our project will set the foundations for similar future queries in the archive of the largest mm ground-based facility, the Atacama Large Millimeter Array, which will probe the coldest gas component of these new flows.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Euro-Chinese Urban and Regional Bi-continental research Scheme' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This program aims at developing joint research and higher education on urban and regional development and planning, bringing together European and Chinese Universities. On the one hand Chinese cities and society are evolving at a very quick pace and Chinese responsible decision makers are aware of the challenge and new issues they are facing. They pay a particular attention to the approaches developed in Europe. On the other hand, European academics traditionally compare their views between themselves and with specialists from all over the world. Obviously, the exceptional experience and the growing importance of China in the global economics and politics gives to cooperation with Chinese universities a particular interest. This exchange programme focuses on spatial planning concept which is gaining in resonance within the EU. In China, spatial planning is among the most important policy means for the government to guide the environmental and social evolution of the world’s biggest and fastest growing country. Within Europe there are very different approaches to managing change within different urban and regional contexts and the same is true within China, where the open door policy has unleashed an unprecedented urban transformation. The role of the project is to explore how policy makers in both Europe and China are managing the rapid transformation of our territories, primarily in urban areas and also in the rural one. The implementation of the programme is based on a networking of four EU universities (Paris 12, Liverpool, Manchester and Utrecht) and one university in China (Nanjing University), which all hold the leading positions in planning education, training and research in their countries. Partners will exchange staff members, junior and PhD researchers around