RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the role of proteins associated with the nuclear pore complex in regulating gene expression and dna double stranded break repair' (1998-2002).

assistant: **Concept**

We propose to study the role of specific proteins of the vertebrate nuclear pore complex in regulating gene expression and mediating DNA double stranded break repair, to help understand the mechanisms of these processes, and also the molecular basis of their contribution to on cogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Technological assessment of Mesolithic portable art in Norway and Ukraine via submillimetre 3D modelling' (TEMPA-3D).

assistant: **Innovation**

TEMPA-3D offers a transdisciplinary approach to study endangered archaeological collections from Kamyana Mohyla, Ukraine and Rogaland, Norway. By fusing photogrammetry and experimental archaeology TEMPA-3D will initiate new research subfield and make an impact on the broader discourse about Mesolithic portable art.The study addresses the lack of targeted investigations of how the engraved ornaments were made, and moves beyond state-of-the-art by developing a method for linking specific surface modifications to particular engraving techniques. By attending art as a process of making, this project will contribute to our understanding of the complex nature of human craft-making and creativity – a topical subject in present society. The main objective is to assess the engraving techniques used for producing the Mesolithic portable art. The chosen case studies, each representing late Mesolithic fishing societies, reveal similarities and variation in art-making technologies and symbolic expressions during the 8-4th millennium BC. Through its innovative methodology, TEMPA-3D will analyse and contextualise 60 engraved sand- and soapstone artefacts. Through a three-stage process it will develop a fluent workflow augmenting the information that can be obtained about the engravings:1) Artefacts’ individual biographies will be analysed by means of recent advancements in photogrammetric submillimetre 3D modelling, developed and patented by the PF.2) A dataset that links specific engraving features to particular techniques will be obtained through actualistic experiments. 10 experimentally made replicas will be produced and 3D modelled.3) To interpret the techniques that were employed by the prehistoric crafters, archaeological and experimental 3D datasets will be compared. The outco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ENSEMBLE-based Predictions of Climate Changes and their Impacts' (ENSEMBLES), addressing dissemination and exploitation.

assistant: **Impact**

Prediction of both natural climate variability and human impact on climate is inherently probabilistic, due to uncertainties in forecast initial conditions, representation of key processes within models, and climatic forcing factors. Hence, reliable estimates of climatic risk can only be made through ensemble integrations of Earth - System Models in which these uncertainties are explicitly incorporated. For the first time ever, a common ensemble forecast system will be developed for use across a range of timescales (seasonal, decadal, and longer) and spatial scales (global, regional, and local). This model system will be used to construct integrated scenarios of future climate change, including both non-intervention and stabilisation scenarios. This will provide a basis for quantitative risk assessment of climate change and climate variability, with emphasis on changes in extremes, including changes in storminess and precipitation, and the severity and frequency of drought, and the effects of surprises", such as the shutdown of the thermohaline circulation. Most importantly, the model system will be extensively validated. Hind casts made by the model system for the 20th century will be compared against quality-controlled, high-resolution girded datasets for Europe. Probability forecasts made with the model system on the seasonal and decadal timescales will also be validated against existing data. The exploitation of the results will be maximised by linking the outputs of the ensemble prediction system to a wide range of applications. In turn, feedbacks from these impact areas back to the climate system will also be addressed. Thus ENSEMBLES will have a structuring effect on European research by bringing together an unprecedented spectrum of world-leading expertise. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A platform supercharging residential property valuations.' (Geowox) targeting Horizon 2020.

assistant: **Abstract**

Geowox provides data-driven residential property valuations in real-time. Our clients are mortgage providers and mortgage investors, who are still served by external manual surveyors, delivering paper or spreadsheet based valuations via e-mail. This process is inaccurate, slow and costly. Geowox brings together the efficiency of big data solutions and the due diligence performed by accredited surveyors.We bring accredited surveyors onto our platform, (supercharging) providing them with Automated Valuation Models (AVMs) and report building modules. We offer specific applications for i) new mortgage valuation (a one time, single unit, home-visit based valuation for new mortgages) and ii) existing mortgage revaluation (a periodic, non-home visit based revaluation during the mortgage lifetime), which are the most common tasks performed by surveyors.The EU/US residential valuation market is worth €1.5bn annually. €500m are served by software solutions, with no accredited surveyor intervention. The remaining €1bn is served by over 150,000 accredited surveyors, performing similar property valuations. The core of our proprietary platform has two main elements: i) a proprietary address encoder, able to enrich uniquely identifiable geo-coordinates and property characteristics to addresses from a wide array of sources. ii) an AVM able to predict residential property value to a Median Absolute Percentage Error (MdAPE) of <10%, with the goal to reduce this to <5% by 2021.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cognitive neuroscience' (1998-2002).

assistant: **Concept**

A series of two meetings aims at discussing the psychological and neural mechanisms involved in the organization of perception and action in human subjects. It has been shown that the internal representation of space involved in these processes is not a unitary system but includes a number of discrete components. Accordingly, disturbances of different aspects of these processes can be observed following brain lesions.Hemispatial neglect, extinction, optic ataxia and agnosia all serve as pathological models to explore selective impairments of visual perception and the visual control of action, and allow us to draw inferences as to their functional and neural organization. The first meeting will focus on spatial neglect and extinction while the second meeting will examine on a broad front the progress and prospects of research, on both healthy and brain-damaged human subjects, into the ways in which bodily movements are controlled and guided by visual information.It will also evaluate the contribution of nonhuman studies of the neural substrates of visuomotor control. Planning this in a European context is highly appropriate, given the lead that European laboratories have already given in these areas. In exploring themes contributed from behavioural, neuropsychological, neuropsychological and functional neuro-imaging studies, the meetings will in part serve as a forum to digest the progress that has been made thus far in our understanding of the neural mechanisms involved in perception and action.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'X-ROTOR: X-shaped Radical Offshore wind Turbine for Overall cost of energy Reduction'.

assistant: **Concept**

As the effects of climate change are becoming ever more visible, Europe has raised its target for the amount of energy itconsumes from renewable sources from the previous goal of 27% to 32% by 2030. Offshore wind energy can play a key rolein achieving the EU target and contribute to the required 40% reduction in CO2 emissions. However, to achieve thepreviously mentioned targets the cost of offshore wind must be reduced. This proposal provides a direct route to creating astep change in the cost of energy from offshore wind through the development of a disruptive new offshore wind turbineconcept known as the “X-Rotor”. The X-Rotor has potential to reduce the cost of energy (CapEx and OpEx) from offshorewind by up to 20%, based on a conservative estimate from early feasibility study work.To quantify and validate the CapEx and OpEx savings, the project team holds a significant successful track record incomputational modelling in the areas of aerodynamic, structural, control, electrical and cost modelling within the wind energysector. Additionally, environmental and socio-economic impact analysis will be carried out to determine the advantages anddisadvantages of the X-Rotor in those areas. GE, a globally leading leader in wind turbine development and manufacturingwill ratify all proof of concept work completed in this project to ensure it is to a standard that can be used in futurecommercialisation. Through the completion of the proposed work by our consortium of leading EU research and industrypartners, this proposal will determine the technological, economic, environmental, and social feasibility of the X-Rotorconcept. If the concept proves feasible, it will, as a disruptive new offshore wind turbine concept, create new opportunities forthe European wind energy industry a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'COURSEWARE AUTHORING FOR SCIENTIFIC TRAINING' in the context of a Fourth Framework call.

assistant: **Objectives**

COAST is seeking an alternative cheaper system for offering science and technology students the all-important benefits of laboratory (lab) practicals. The project uses mathematical models and multimedia material in an authoring package for simulation-based practicals suitable for delivery on the Internet (see KAMP). It will be piloted on practical work in electronics at three sites by teachers and students of medicine. COAST will be externally evaluated with a view to broader applications, and the definition of practicals-related copyright agreements will also be closely considered.In most educational institutions involved in scientific training, the delivery of good quality practicals is now impeded by cost and/or practicality constraints. However praticals are compulsory to a good scientific and training curriculum. The main objective of the COAST project - COurseware Authoring for Scientific Training - is to provide scientists with new technological and cost-effective means, more specifically based on multimedia simulation, to prepare their material so as to gradually replace lab practicals that are getting more and more expensive, and to improve their student's understanding of complex systems.Technological development will mainly concern the design and development of an authoring package for simulation based practicals in scientific and technical education. On the basis of existing mathematical models, an author (who is a domain's specialist but not a simulation modeller) can prepare simulation environments, the scenarios of practicals and their didactic components, and integrate multimedia material.The practicals thus developed can be delivered to tutors and students in universities through Internet. Another project, called KAMP, will supply telematics services fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of low-calorie beverages with prebiotic properties from cheap and abundant feedstocks' (2007-2013).

assistant: **Concept**

The demand for healthier and low-calorie foods is increasing worldwide. Galactooligosaccharides and fructooligosaccharides are considered to be naturally-occuring prebiotics because they can selectively stimulate the growth of beneficial bacteria in the colon, and thus, improve host health. These oligosaccharides (OS) also have excellent technological properties regarding to viscosity, stability, solubility, and taste. A common weakness of the current OS production technologies is the incomplete bioconversion that results in a carbohydrate mixture consisting of a considerable amount of residual disaccharides and monosaccharides. Further purification of this mixture involves complex, high-cost and low-yield technologies that restricts the application of OS in low-calorie food formulations.This 4-year research project is devoted to the development of a novel technology for manufacturing low-calorie, value-added beverages that have beneficial health effects. The proposed technology has two key steps. First, the sugars present in cheap and abundant feedstocks available within the EU, such as whey and molasses, are partially converted into valuable OS. Then, the obtained saccharide mixtures are further processed in a selective fermentation step using appropriate microorganisms that are capable of utilizing mono- and disaccharides but lack the power to hydrolyze OS to a higher extent. The utilized carbon source is not wasted but required for giving rise to odour and taste constituents. The resulting mildly sweet product has a prebiotic function due to the presence of remaining OS.This highly multi-disciplinary research gathers new experimental data, involves 'state of the art' experimental and theoretical analysis on fundamental phenomena and their implications to real-life s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sulfate Reduction dependent Anaerobic Methane Oxidation in Novel Membrane and Electrochemical Bioreactors' (SUREANMETOX).

assistant: **Innovation**

Methane (CH4) is a potent greenhouse gas produced in diverse terrestrial subsurface and marine ecosystems. However, the amount of CH4 emitted to the atmosphere from these ecosystems is largely reduced by methanotrophic microorganisms –microbes that oxidize CH4 to obtain energy and carbon source for their metabolism. Methane oxidation can occur aerobically or anaerobically. While extensive information is available on aerobic methanotrophs’ biochemistry, physiology and ecology, little is known about anaerobic methanotrophs.Anaerobic CH4 oxidation has thus far mostly been investigated in marine ecosystems. There, CH4 oxidation is coupled to the reduction of sulfate. It is believed that the reaction occurs via a syntrophic cooperation in which anaerobic methanotrophs transfer electrons to a sulfate reducing bacterium thus the overall reaction is energetically feasible. However, the exact nature of the syntrophy and the identity of the electron transfer compound(s) remain unknown. Moreover, no pure culture or defined consortium of these microorganisms is available. This hampers detailed metabolic and physiology understanding of the process.Here we propose using innovative bubble-less membrane and electrochemical bioreactors to obtain robust enrichment cultures and to explore the mechanism of electron transfer. The nature of the syntrophy of the microorganisms involved will be assessed using stable isotopes labeled substrates. Incorporation of labeled atoms into biomass –lipids and –fatty acids (LFA) will be determined after cell-sorting of fluorescent labeled various archaea, and bacteria cells types. This new approach may allow exploiting the high sensitivity of stable isotope probing of LFA while attaining good microorganisms’ identity resolution. Metabolomic studies of an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Land animal evolution: genomic landmarks on the path to terrestrial life', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

All animals share a common origin: a marine one. To conquer land from marine environments, animals changed radically the way they breath, reproduce, move or smell. And they did it multiple times in the history of Earth, with terrestrial animals massively outnumbering aquatic ones. Understanding terrestrialization is therefore key to comprehending animal biodiversity and biological adaptation. Despite the relevance of such an episode, the genetic underpinnings orchestrating terrestrialization in animals are largely unexplored. The project will test the hypothesis that animals are equipped with a highly plastic ‘terrestrialization genetic toolkit’ that allowed their adaptation to the extreme environmental conditions in terrestrial ecosystems. We will focus on two pivotal questions: which genes facilitated life on land and how do they differ between aquatic and terrestrial animals?, and how did animals reshape their genomes to adapt to dry land? Moreover, we will study two case examples of critical processes common to all terrestrial animals -breathing and protection against UV light- to illuminate what molecular and biochemical changes allowed terrestrial animals to breathe and repair their DNA after UV light damage. To achieve this, we will (i) identify the gene repertoire orchestrating the extreme physiological and metabolic changes in aquatic and terrestrial lineages, (ii) characterize the dynamics of these genes to understand the role of gene loss, duplications and horizontal gene transfer, and (3) discover the adaptive mutations that led respiratory pigments and DNA repair proteins to gain their functions via molecular engineering techniques to resurrect their ancestral ‘paleophenotypes’. This project will deliver fundamental insights into a core question in evolutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The mechanism of retrograde trafficking by retromer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Transportation of proteins and lipids between membrane-enclosed organelles by vesicle formation is a fundamental task in eukaryote cells. The least understood protein complex involved in membrane remodelling for vesiculation, but with a wide range of medical implications, is the retromer complex.The objective of this proposal is:First, to identify the mechanistic principles of membrane bending and scission by retromer, and second to characterize temporal and morphological aspects of retromer and cargo molecules (Shiga toxin (STx) and Alzheimer’s amyloid-beta-cleaving enzyme (BACE)).I will exploit two approaches:First, in vitro reconstitution of the retromer complex using giant unilamellar vesicles to deploy biophysical methods.Second, I will provide a molecular choreography and anatomy of retrograde transport of STx, BACE and retromer by implementing a new imaging technique, structured-illumination microscopy combined with single particle tracking.The proposed interdisciplinary research will break new ground for membrane mechanics and trafficking of disease related cargo molecules.