RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Counter-acting the pandemic potential of flaviviruses: addressing virus-host interactions and defense strategies to design new therapeutics against  WNV and DENV' (InFlaMe).

assistant: **Concept**

To strengthen EU's ability to fight DENV and WNV epidemic and pandemic  threats and elaborate effective emergency plans. The project is based on three pillars: 1) clinical investigation of host factors related to severe disease, 2) therapeutic development (i.e. host-viral protein binding inhibitors) and 3) One-Health-based surveillance of the infections. Open science practices will guarantee quality, efficiency of the research and maximise the impact of the project. The declaration of interest in the InFlaMe project of a company, world leader in the field, supports the thrustable of the network and the impact of the project’s expected outcomes. The project’s tasks will proactively be addressed in 7  sounding work packages  and will go beyond the state-of-the-art. The partners have outstanding experience in all the aspects of the project, collaborated previously and working together on emerging flaviviral infections. The team includes Fondazione IRCCS Policlinico San Matteo as coordinator (IT; Fausto Baldanti), the National Institute of Molecular Genetics  (IT; Renata Grifantini, Antonio Lanzavecchia and Raffaele De Francesco),  Pasteur Institute (FR; Jouvenet Nolween),  CIC Biogune Institute (ES; Jesus Jimenos-Barberez and Nicola Abrescia), University of Florence (IT; Cristina Nativi),  Centro Nazionale per le Ricerche (IT; Giovanni Maga and Paolo Mazzetti ), Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna (IT; Ana Maria Moreno Martin), IMAGINE Institute (FR; Jean Laurent Casanova and Shen-Ying Zhang,), University of Vienna (AT; Judith Aberle and Karin Stiasny) and University of Masaryk (Daniel Ruzek). This truly complementary and collaborating network  has a robust know-how in diagnosis of flaviviruses in humans and animals, on host-pathogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advancing the Scalability and Performance of I/O Subsystems in Multi-core Platforms' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Data storage technology today faces many challenges, including performance inefficiencies, inadequate dependability and integrity guarantees, limited scalability, loss of confidentiality, poor resource sharing, and increased ownership and management costs. Given the importance of both direct-attached and networked storage systems for modern applications, it becomes imperative to address these issues. Multicore CPUs offer the promise of dealing with many of the underlying limitations of today's I/O architectures. However, this requires careful consideration of architectural and systems issues and complex interactions in the I/O stack, all the way from the application to the disk.<br/>In this proposal we target three major challenges: (i) dealing with performance and scalability issues of the I/O stack on multicore architectures, (ii) addressing I/O performance and dynamic resource management issues in virtualised, single-host environments, and (iii) examining on-loading and off-loading tradeoffs for advanced functions that are becoming essential in modern storage systems, e.g. compression, protection, encryption, error correction; on-loading uses free cores of multicore CPUs, whereas off-loading uses specialized architectural features, such as heterogeneous units.<br/>This project aims at analyzing and addressing these challenges throughout the I/O path. Our approach breaks down the I/O stack in four important layers: (a) application and middleware, (b) virtual machine, (c) host operating system, and (d) embedded storage controller. The proposed work analyzes and addresses the inefficiencies associated with these layers on multicore CPUs, by designing an I/O stack that minimizes unnecessary overheads and scales with the number of cores. Since storage systems are perhaps
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cloud-aERosol inTeractions & their impActs IN The earth sYstem' to be submitted under Horizon Europe.

assistant: **Abstract**

Cloud, aerosols and their interactions are key regulators of climate. However, uncertainties in the magnitude of the net cooling impact of aerosols on climate and in the cloud response to evolving anthropogenic emissions and climate change induced feedbacks on natural emissions are major challenges that limit our understanding of how global and regional climate, including extremes, respond to changes in greenhouse gases. It is of paramount importance to better understand aerosol-cloud processes and their role in the Earth System, from regional to global scales, and over different time scales, from days to decades. Over the last decade, extensive research networks, infrastructures, satellite instruments, and atmospheric models have been developed, making it possible to obtain a holistic view of the effects of clouds and aerosols on climate and weather. CERTAINTY will capitalise on this available data together with advanced algorithms, machine learning and data assimilation methods, high resolution models, and Earth system models to bring the fundamental knowledge of interactions between clouds, aerosols, and radiation to a new level. The consortium partners are in key roles as operators, data originators, developers, providers, and users of European aerosol and cloud data and ESMs/high resolution models. The consortium leads the activities of next generation satellite missions (such as EarthCARE), and the development of new satellite products, to facilitate their scientific use in CERTAINTY by preparing tools for early adoption of data. CERTAINTY will bring the observation-based knowledge to be used in modeling frameworks to improve predictive models and knowledge of processes controlling aerosols, clouds, and their interactions from hours to decades. The ultimate outcom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High Performance Bio-based Functional Coatings for Wood and Decorative Applications' (PERFECOAT), addressing dissemination and exploitation.

assistant: **Impact**

Achieving a climate-neutral Europe by 2050 requires the replacement of fossil-based material with bio-based material on a broad basis. Today, ca. 900 kt/y paints and coatings are produced in Europe, with more than 80% still being from fossil resources. Wood and decorative coatings represent a large market, accounting for more than half of that volume. The goal of the PERFECOAT project is to develop and validate a new generation of industrial wood and decorative coatings with significantly more than 25% bio-based components that meet and even surpass the current quality and sustainability standards. Our concept is based on a flexible platform of novel technologies to produce and functionalize new, bio-based bulk coating components and assemble them into new coating formulations. Three major coating markets will be addressed: 1) high-volume ultraviolet (UV)-curable clearcoats, 2) do-it-yourself (DIY) waterborne trim paints, and 3) DIY waterborne wall paints. End-of-life scenarios plus economic, environmental, and social assessments will support the technological development in PERFECOAT, to guarantee a high level of sustainability throughout the value chain. The coating ingredients and final coating blends produced by PERFECOAT will be tested for safety compatibility at different stages of their development. High performance of new advanced bio-based binders, fillers and additives will be systematically developed and validated in coatings, starting from a proof of concept (TRL3) to demonstrator validation (TRL5). PERFECOAT is implemented by a strong, well-balanced, multidisciplinary consortium of experts from 4 universities and research institutes and 8 commercial project partners, including 4 SMEs, in 7 member countries. All partners are committed and highly motivated to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A game change in continuous biosensing: Molecularly engineered affinity-based nanoswitches for personal monitoring' (CONSENSE).

assistant: **Concept**

Generic technology that allows continuous sensing of a wide range of biomolecular parameters could revolutionise patient monitoring and enable truly personalised therapy. Commercial sensors  are available for continuous monitoring of glucose, but do not exist for other molecules that are important for monitoring disease status and treatment effect, including peptides, proteins, hormones, and drugs. The ambition of CONSENSE is to provide a game change in continuous biomolecular sensing by combining advanced molecular engineering with tailored optical detection technologies to yield generic, affinity-based biosensing technologies. CONSENSE will focus on the construction of biomolecular nanoswitches that translate molecular binding into robust and well-defined conformational changes at length scales that can be detected by selected optical detection methods, providing unique possibilities to distinguish between specific and nonspecific binding. While the applications for this new technology are wide and varied, within CONSENSE we will focus on immune monitoring in critical care settings, where patients have an urgent need for continuous monitoring related to inflammation and immunotherapy. CONSENSE brings together internationally leading pioneers in biomolecular switch engineering with research groups that have an excellent track record in biosensor development using advanced optical approaches, including two high-tech companies that have spun out from these groups. The consortium is completed by a strong network of partner industries and organisations, including four large medical technology companies, clinical experts, and seven SMEs providing specific technological expertise and training. The consortium will provide exceptional training to 15 ESRs, allowing them to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NO-dependent protein translocation and S-nitrosylation of nuclear proteins in Arabidopsis thaliana' under Seventh Framework.

assistant: **Concept**

During the last two decades nitric oxide (NO) has emerged as a new chemical messenger in plant biology, which is involved in regulation of many different physiological processes, such as plant defense, transpiration and gas exchange, seed germination, and root development. It is common that many of the biological functions of NO arise as a direct consequence of chemical reactions between proteins and NO or NO oxides. As result of this modification protein activities can be altered, ion channels, transcription factors and signalling proteins can be regulated, the conformation of structural proteins can be altered or proteins can be translocated. Protein translocation is a very important signalling mechanism and there are many reports about protein trafficking during different physiological processes published. However, less is known about NO-dependent protein translocation – especially in the plant field. Based on a proteomics approach we want to investigate the NO-dependent translocation of proteins into the nucleus. Furthermore, a map of nuclear proteins should be generated, which are candidates for protein S-nitrosylation. Besides these proteomic approaches the NPR1/TGA1 system, which is known to be regulated by nitric oxide, will be analysed in more detail. The bZIP transcription factor TGA1 and the regulatory protein NPR1 together are playing a crucial role in SAR during the inducible plant defense response. 3D structures of both proteins will be determined in presence of nitric oxide, to analyse the structural alteration, which result in more effective DNA-binding activity of TGA1. The aim of these studies is to get insight into the regulatory function of NO in gene transcription.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Seasonal dietary antioxidant levels in relation to human health; a molecular epidemiological study' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Foreseen ResultsThere is a growing awareness of potentially serious nutritional deficiencies in central/eastern Europe, affecting human health. This study will define the extent of the problem and explore the possibilities of rectifying it.The very high levels of cardiovascular disease and certain cancers in central and eastern Europe are likely to be caused in part by nutritional deficiencies. A conspicuous feature of the diet in these countries is the restricted availability of fresh fruit and vegetables in winter, which is likely to lead to poor antioxidant status. Applying sensitive tests for biomarkers of oxidative damage to lipids and DNA (taken as indicators of risk of cardiovascular disease and cancer, respectively), as well as assays for antioxidants in plasma, we will investigate the biological consequences of this seasonal variation in three groups of volunteers in Slovakia: (a) normal healthy controls, matched with (b) hyperlipidaemic heart attack survivors, and their relatives (c). We will carry out a supplementation trial to adjust the winter level of antioxidants to that typical of the summer diet. The effect of this intervention on biomarkers of DNA and lipid damage will be monitored. In parallel, animal and cell culture experiments will allow us to examine the mechanism underlying the protective effect of dietary constituents.This proposal arises from an existing Copernicus collaboration which has successfully established the central assay for DNA damage - the comet assay" - in all the laboratories participating in this initiative.The Research Topics that we are addressing are Agro-Food: Toxicology role of biomarkers for presence of toxic substances, the interaction of compounds which have a positive or negative health effect ) and Food quality ("...asp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HOst-Transposon Interactions in the MAle GErmline' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Transposable elements (TEs) are mobile DNA sequences that have massively colonized mammalian genomes. Host genomes and TEs are engaged in ambiguous trade-offs, whereby TEs can be co-opted for genomic upgrades over evolutionary timescales, but they should also be suppressed to protect genome stability and function. Effective and multi-layered surveillance is primordial: TE reactivation is associated with various dysfunctional states, including infertility, ageing, cancer or neurological disorders, involving both transposition-dependent or -independent routes. Understanding the two-way relationship between host genomes and their TE integrants is an essential and fascinating topic, with far-reaching impact on development, evolution and disease.Here I propose to uncover and functionally challenge the molecular arrangements that genomes and TEs came upon for the sake of germline development and fertility. The germline is a highly relevant context, as this is where host-TE interests are the most conflicting, and from their outcome depend reproductive success and species fitness. I will specifically question how TE transcription is transiently tolerated during germline reprogramming and whether it could be purposely used for the early germline program. Using the mouse model, we will deploy innovative and ambitious approaches including in vivo epigenome editing of TE activity, single-cell multimodal profiling, and advanced molecular profiling and microscopy to investigate i) the molecular bases of mutualistic relationships between germ cells and TEs, ii) the dynamic coordination of host-TE interactions within germ cell nuclei, iii) the consequences of dysfunctional host-TE interactions on meiosis. By harnessing our unique expertise and tools and by going beyond correlations, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High-performance aerodynamics and aeroacoustics simulations of the new generation of high-speed gas turbines via high-order Galerkin methods' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main goal of this project is to perform efficient and accurate simulations of the turbulent compressible flow and generated noise on the new high-speed gas turbines at operation conditions, with the aim of supporting engineers in the design of efficient engines and effective noise reduction solutions. The main difficulty is to correctly simulate, in an acceptable wall- clock time, high Reynolds and high Mach numbers turbulent flows with important regions of separation and the different length scales and amplitudes among the acoustic and the flow fields.In this project we propose to tackle these problems by introducing high-order Galerkin methods and a skin friction boundary condition technique extended to compressible flows. Both techniques demonstrated impressive performance results on a different context. Given the fellow’s expertise in compressible flows, and her Third Country host’s expertise in high-order Galerkin methods, we are in a unique position to advance in the solution of this problem. A high performance computing simulation tool developed at the host institution will be used and developed as open source within this project. To go one step further within this interdisciplinary subject, we will establish a close collaboration with CTA, a company in the host country specialized in testing aerospace materials, where the fellow will spend one month of research. During this visit, the simulation results of their turbine prototypes will be analyzed and will be validated against their experimental data.The fellow will extend her network in the scientific and industrial communities. She will gain new managerial skills and a scientific maturity that will open her doors to obtain a strong research position in Europe. The host and the Third Country host supervisor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Experimental generation of distant quantum dot spin entanglement' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Quantum dot spins, known as “artificial atoms”, not only provide platforms for studying spin dynamics in a solid-state environment, but also serve as promising candidates for implementing scalable quantum computation. Considerate efforts have been devoted to manipulating quantum dot spins as qubits. Precise preparation of initial qubits and complete control of a single quantum spin with optical means have been reported. Until now, however, the generation of distant quantum dot spin entanglement still remains challenging. Here, we propose to prepare quantum dot spin entangled states by making the photons from two distant quantum dots interfering on a wave-guide beam splitter, which is out of reach of all previous experiments. We also plan to study problems of fundamental importance in quantum mechanics, such as entanglement swapping, entanglement purification and testing of Bell inequality with quantum dot spins.""