RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Allosteric modulation of immune checkpoint complexes as a new mode of therapeutic intervention in immunotherapy' to be submitted under Horizon Europe.

assistant: **Abstract**

The fastidious balance of our immune system to fight infections or cancer while avoiding autoimmune reactions is regulated by coinhibitory and co-stimulatory immune checkpoint complexes (ICCs), which have become major drug targets. We witness the skyrocketing progression in cancer immunotherapy with antibodies that block inhibitory ICCs whereas Abs that block stimulatory ICCs are in clinical trials for treating autoimmune diseases.Surprisingly, but likely fuelled by the most obvious focus on IC inhibitors, the field largely ignored that ICCs are genuine transmembrane receptors that transmit signals upon binding of an extracellular protein ligand. This leaves unexplored modes of therapeutic intervention that I will uncover by validating Nanobodies (Nbs) as first-in-class modulators of signaling pathways associated with immune receptors in a unique, previously unexplored fashion. By applying innovative immunization and bio-selection techniques and building on POC data, I will deliver Nbs for representative ICCs to demonstrate the efficacy and selectivity of these Nbs in preclinical models of various inflammatory conditions, focusing on cancer and autoimmune diseases. We will deliver novel therapeutics agents which may outperform current inhibitor-based immunotherapies that trigger a magnitude of side effects. In this regard, the Nbs will exert their therapeutic effect through a distinctive mode of action that will ensure patient safety, even in the event of an overdose.


**Keywords:** Nanobody technology, Immune checkpoint complexes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Oligo-Vascular interface: understanding its properties and functions' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Oligodendrocytes (OLs) are the glia cells that produce myelin in the central nervous system (CNS). Despite the severe outcome of demyelinating diseases, like multiple sclerosis (MS), little is known about the mechanisms by which myelin is disrupted or why remyelination fails in disease. Thus, a substantial advance in the understanding of oligodendrocyte biology and myelin pathology is required in order to develop successful treatments for demyelinating diseases.Recent research indicates that apart from delivering oxygen and nutrients, blood vessels are active regulators of organ function. Our recent work supports the existence of an oligo-vascular interface where vessels directly control oligodendrogenesis. However, mechanistic insights of the interaction between OLs and the vasculature are lacking. Based on the innovative hypothesis that proper generation and OL functionality depends on active crosstalk with the vasculature, the OLI.VAS project will now tackle the challenge to characterize in depth the interaction between OLs and the vasculature during development and demyelinating diseases. To achieve this goal, two complementary multidisciplinary research tracks are pursued: Research track 1: Deconstructing and reconstructing the oligo-vascular interface to unravel the relationship of oligodendrocyte lineage cells with the vasculatureResearch track 2: Studying the oligo-vascular interface in white matter lesions. Modulating the vasculature to prevent de-myelination or promote of re-myelinationBoth tracks combine cutting edge technology in single cell and spatial transcriptomics, bioinformatics, 3D imaging, in vitro and ex vivo tissue culture, mouse genetics and MS patient samples. OLI.VAS will deliver new insights into the role of the vasculature as a regulator of ol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Electronic Democracy European Network'.

assistant: **Concept**

The goal of EDEN is to allow a true bi-directional communication between citizens and Public Administration's staff. The project will achieve this goal by defining a multimedia platform for democratic consultation. The software platform will integrate tools based on new emerging technologies (NLP and Mobile Communication Protocols) in order to improve the accessibility and user-friendliness; it will be designed according to user requirements emerging from current problems and experiences in civic consultation; the pilot sites will develop applications in the domain of Urban Planning, based on the common platform, to perform real test and collect results.OBJECTIVESThe general objective of the EDEN Project is the improvement of communication between Public Administrations (PA) and citizens in decision-making processes. The improvement to be obtained will be threefold: qualitative by simplifying access to professional quality data (support through Natural Language Processing (NLP) or by providing different views of a linked city map electronically; quantitative by offering access using different media, in order to reach the generally missing mass participation to Public Administration processes; and economically, by reducing the cost per citizens' participation action. Such an ambitious objective will be reached through the integration of tools into existing infrastructures which allow citizens to dialogue with the Public Administration using their natural language, so obtaining a direct pre-structured and, at the same time, richer interaction. Such tools will be developed for general purpose - thus as reusable as possible. The application context which has been chosen for carrying out pilots is that of urban planning networks, which involve a number of different groups, s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Single object, single chain and single molecule excited state properties imaged by scanning confocal fluorescence microscopy coupled to atomic force microscopy'.

assistant: **Objectives**

Research objectives and content The research group has synthesized a set of dendrimeric structures with a single chromophore at the core of the dendritic structure. The excited state properties of these single object, single chain and single molecules will be investigated using a plate scanning confocal microscope coupled to an atomic force microscope (AFM). The AFM will locate the object deposited on a transparent surface and the scanning confocal fluorescence microscope coupled to an optical multichannel analyzer and to a single photon timing set up will allow in depth study of the excited state properties of the object. The role of the coupling between the 'arms' or branches and the excited state properties of the central core will be investigated. In a second step the electron transfer between a single donor and a single acceptor will be examined. The exact distance will be measured and manipulated. Training content (objective, benefit and expected impact) The present proposal builds on my knowledge in photophysics, photochemistry, laser physics and spectroscopy which I received in my undergraduate and PhD program but extends it in a new dimension namely small domains and nanometer or subnanometer resolution. This will allow me to get acquainted with the recently developed scanning confocal and probe techniques and to develope new application to photochemistry, photophysics and photobiology. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bit-interleaved sigma-delta modulation over fiber' (BI-SDMoF).

assistant: **Concept**

Network operators are struggling on how to release broadband mobile services in highly dense and hot-spot scenarios. The 5th generation of mobile networks is targeting per user downlink and uplink rates of 300 Mb/s and 50 Mb/s respectively. In ultra-dense environments such as stadiums, airports, shopping malls and tourist hot-spots, the aggregated bit rate becomes enormous. To make it more concrete, Belgium’s national football stadium (King Baudouin) is taken as example. The stadium can accommodate 50000 spectators. Even if an average bit-rate of only 50 Mb/s needs to be provided, an aggregated bit-rate of 2.5 Tb/s is required. Given the small area of a stadium (18 000 m2 seating area), this results in an astonishing capacity per area of 140 Tb/s/km2 or 140 Mb/s/m2. This is a 10-fold increase compared to area traffic capacity targeted in 5G and a 100-fold increase compared to the current 4G technologies. In order to make this 10-fold increase happen, the BI-SDMoF proposal (Bit-Interleaved Sigma-Delta Modulation over Fiber) builds on patent pending technologies currently developed in the ATTO Advanced ERC grant (“A new concept for ultra-high capacity wireless networks”). Whereas the ATTO project is using floor and robot integrated antenna’s with a target density of 100 Gb/s/m2 and targets a long term market potential, the BI-SDMoF PoC will focus on applying basic components from the ATTO project in a 5G fiber-fronthaul Centralized Radio Access Network (C-RAN) and Distributed Antenna System (DAS) context that is much closer to the market. The target density is 150 Mb/s/m2 and a distributed Massive MIMO scenario is envisaged.  As a PoC demonstrator a low power, low cost 28 GHz RRH  (Radio Resource Head) supporting two antenna streams with four 400 MBd channels each will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Data-Grid Environment and Tools for Distributed Management and Analysis of Large Sets of Scientific Data'.

assistant: **Concept**

Grid based computational infrastructure has emerged as a natural response to the demands of computing applications worldwide which are becoming more complex and demanding in terms of resources as well as increasingly collaborative and interdisciplinary. We will create a framework for Data-Grid computing that unifies resource access and representation in a user-friendly environment that is ubiquitous, adaptive, robust, and scalable. This will be prototyped on key test-bed activities that have been chosen by their intrinsic scientific merit, their reliance on remote data access, and their connections to international Grid efforts. These test-beds in the areas of particle physics, astrophysics and bioinformatics will allow researchers to analyse remote data and make scientific measurements that would not be possible without recourse to Data-Grid tools. Knowledge transfer is vital to the success of this project. The consortium presenting this proposal has expertise in the area of the core computer science (parallel processing, parallel architectures, scheduling, heterogeneous distributed systems, dynamic load balancing, artificial neural networks, and optimisation techniques), and the applications (particle physics, astrophysics and bioinformatics). What is missing are the links between the two: people with Grid experience of real world applications and software engineers who can implement our vision. An outreach component to our project will allow us to deploy Data-Grid technology across a variety of activities in both the academic and commercial worlds. Use of our framework in a wide range of disparate activities will allow for a widespread use of the tools for e-science, e-commerce, and the public at large. We will make significant contributions to international data-Gri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Credit Safety Net and the Costs of Credit Supply Shocks', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The project The Credit Safety Net and the Costs of Credit Supply Shocks (CSCS) examines the effects of lender-imposed credit supply dynamics on households ability to weather idiosyncratic income shocks that are unrelated to the business cycle. It relies on longitudinal household surveys and leverages unexpected and exogenous health shocks to identify individual-specific, random variations in exposure to credit supply shocks. Beyond the foregone satisfaction of current consumption, CSCS emphasizes welfare costs by examining not only changes in household consumption and savings but also other financial coping strategies. These include asset divestments, such as exiting homeownership, and behavioral changes related to income-generating activities, like working overtime or taking sick leave. These outcome variables are crucial for welfare considerations given their implications for health and life quality conditions, yet they are often overlooked when evaluating the costs of imperfect credit markets. The policy implications are immediate and relate to a potential need for social insurance mechanisms to provide effective insurance for households.


**Keywords:** Financial Intermediation, Credit Safety Net, Credit Supply Shocks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'oculavis SHARE: The Remote Service Platform for B2B service processes based on Augmented Reality and Artificial Intelligence Technologies' (2014-2020) under Horizon 2020.

assistant: **Objectives**

About 20 Million European service technicians, quality managers or know-how carriers travel daily all over the world to support clients for industrial service or troubleshooting. To avoid travel costs, CO2-emissions and machine downtimes by up to 50%, the Software-as-a-Service (SaaS) platform oculavis SHARE offers virtual service functionalities to connect manufacturers with their clients. Even for highly complex tasks technicians can support their clients while staying at home.oculavis SHARE is the innovative Remote Service Platform for the industry, offering company-branded and customizable service apps, ready-to-use Augmented Reality (AR) and Artificial Intelligence (AI) applications. SHARE allows clients to offer digitized service business models in addition to their hardware products. The software is modular and scalable while meeting individual demands by means of configuration. Use-cases covered by SHARE are typical service tasks occurring in complex production environments like troubleshooting, spare parts ordering, remote support, AR-instructions, service chat, ticket requests as well as data and event-based visualizations. Technicians access the mobile apps typically with Smartphones, Tablets or Smart Glasses.Founded in May 2016, oculavis employs 25 persons today. It reached the Top3 of the most important German Founders Award (“Deutscher Gründerpreis 2018”). The company is owned and lead by the three friends Dr. Markus Große Böckmann (34 years old), Philipp Siebenkotten (34) and Martin Plutz (34) and has over 100 SHARE-installations in paid Proof-of-Concept (PoC) projects with enterprises and SME. Projects and software licenses increased the turnover to 1.45 Million Euro in 2018. oculavis applies for this EU-funded project to develop the SaaS-feature for scal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Thinking Deep-Novel Creative Approaches to the Underground' to be submitted under Horizon 2020.

assistant: **Abstract**

THINK DEEP pioneers a creative practice driven interdisciplinary approach to the underground.It begins from the dual premise that, firstly the underground (or subterranean) is both the site of current environmental concerns (e.g. extraction), and the setting for developing solutions to these concerns. But that secondly, currently we lack approaches that adequately understand the underground, its current use and conservation, and its future possibilities. Underground scholars have long argued that what is needed is an interdisciplinary approach, as yet, however, where interdisciplinarity has been achieved, it has largely brought together science and social science. Unconventionally, THINK DEEP situates creative practices (such as visual art or participatory theatre) together with arts and humanities theories as the cornerstone of an interdisciplinary response to three pressing underground research problems:1. How to sense the underground, an often inaccessible environment? 2. How to contend with varied underground imaginations, which shape underground understanding, use and conservation?  3. How to understand the speculative nature of ‘knowing’ the underground?It will address these problems through global case studies from three fields of underground research: geoscience, underground urban studies, and geoconservation.Its unconventional ambition enables THINK DEEP to deliver a timely and distinctive new contribution to underground scholarship that will transform the field’s future research directions. Furthermore, the project’s pioneering approach will bring about a step-change in relations between creative practices and research more generally. In understanding and evaluating the creative practice and research relations that sit at its heart, THINK DEEP enables ground-b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simulators and Interfaces with Quantum Systems' under Seventh Framework.

assistant: **Concept**

The overarching goal of our project is to develop systems based on direct and deterministic interactions between individual quantum entities, which by involving large-scale entanglement can outperform classical systems in a series of relevant applications.We plan to achieve that by improving technologies from atomic, molecular and optical physics as well as from solid-state physics, and by developing new ones, including combinations across those different domains. We will explore a wide range of experimental platforms as enabling technologies: from cold collisions or Rydberg blockade in neutral atoms to electrostatic or spin interactions in charged systems like trapped ions and quantum dots; from photon-phonon interactions in nano-mechanics to photon-photon interactions in cavity quantum electrodynamics and to spin-photon interactions in diamond color centers.We will work on two deeply interconnected lines to build experimentally working implementations of quantum simulators and of quantum interfaces. This will enable us to conceive and realize applications exploiting those devices for simulating important problems in other fields of physics, as well as for carrying out protocols outperforming classical communication and measurement systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Integrated inter-sector framework to increase the thermal resilience of European workers in the context of global warming' to be submitted under Horizon 2020.

assistant: **Abstract**

Environmental heating is a growing challenge for our community and problems are already experienced by millions of Europeans during the summertime and aggravated during heat waves or occupational settings. In addition to the well-known health risks related to severe heat stress, a number of studies have confirmed significant loss of productivity due to hyperthermia. Even if countries adopt the EU proposal for limiting global CO2 emissions, climate change and its associated threat to public health will continue for many decades. Thus, it is crucial to develop strategies to mitigate the detrimental health and societal effects of these environmental changes.Stakeholders such as policy makers and the private sector usually lack the technical capabilities or facilities to conduct R&D activities at the level of excellence required for such development. European research institutes have the capacity to conduct the R&D necessary to develop solutions. However, they often lack the capacity to transform these solutions into policies and assess their health, economic and social benefits. The HEAT-SHIELD project will create a sustainable inter-sector framework that will promote health as well as productivity for European citizens in the context of global warming. The project will produce a series of state-of-the-art innovative outcomes including: (i) appropriate technical and biophysical research-based solutions to be implemented when the ambient temperature poses a health threat or impairs productivity (ii) a weather-based warning system with online open access service that anticipates the events that may pose a threat to workers’ health; (iii) scenario-specific policies and solutions aimed at health promotion and preventing loss of productivity (iv) implementation of the formulate