RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The development of hypoxia-activated probes for imaging and therapy' under Seventh Framework.

assistant: **Concept**

Solid tumours contain hypoxic cells, which exist at a low oxygen tensions and are resistant to chemotherapy and radiotherapy. Although problematic for therapy, any quality that distinguishes tumour cells from healthy ones presents an opportunity for targeting therapies. We have begun developing prodrugs that selectively release inhibitors of cancer-related enzymes under hypoxia. In this project, we will develop hypoxia-activated inhibitors of the checkpoint kinase, Chk1, which is an important chemotherapeutic target. Allowing targeting of this compound to tumour cells. In addition, to enable imaging of hypoxic tumours we will develop novel hypoxia-activated fluorescent probes. The 2-nitroimidazole-based pimonidazole is a standard hypoxia-imaging agent. Pimonidazole binds cellular thiols under hypoxic conditions but the spatial resolution of imaging is poor. To improve the imaging resolution, we will develop a fluorogenic hypoxia-activated protecting group that will become fluorescent upon release of the active compound. This will provide a read-out of when and where the active compound is delivered, and fill also find application in the general imaging of hypoxia. We then aim to apply this technology to developing hypoxia-activated inhibitors of the cAMP response element binding protein binding protein (CREBBP) bromodomain. CREBBP is a histone acetyl transferase involved in regulating transcription; it has ~400 interacting protein partners making it a key node in the mammalian protein-protein interactome. One partner is hypoxia-inducible factor-1α (HIF-1α), which is a transcription factor that responds to changes in cellular oxygen levels. Given the large number of CREBBP interacting partners it is preferable to target the CREBBP bromodomain inhibitor using a hypoxia-ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'SOFTWARE FEDERATIONS BY MODEL COMPOSITION'.

assistant: **Innovation**

The software developers' community agrees, to some extend, in saying that the all object approach to software engineering is not fully satisfactory. Different new approaches are under investigation, most notably the Component Based Software Engineering (CBSE) - which is relatively mature and usable - the Aspect Oriented Programming (AOP) - somehow less mature - and more recently the Model Driven Architecture (MDA) - in its very early stages. This project addresses the software federations - a state of the art approach developed by the host team - Laboratories Logicians Systems Roseau (LSR) - Granola, which relies to all these technologies and approaches, and proposes a conceptual framework in which complex, heterogeneous and distributed applications can be developed. The major goal is to provide ways to develop applications from software tools currently available on the market. Recently, federations have been extended to address the issues raised by the design of applications based on platform independent models, in such a way to be MDA compliant. While the approach is appealing, many issues are still pending, both from the conceptual and technical sides. Conceptually, the semantic relationships between models need to be refined and experimented, to assess how relevant they are. Technically, the way these relationships are implemented, generated and managed is still major issue.This work will address the following issues:- design by model composition and model structuration (at meta level, model level and execution levels);- identification and experimentation of the associated design and development methodology; - definition of the generation technique(s);- concepts and tools for the definition (modelling) of the application evolution and its dynamic management; - real
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'FLuorescent nanO-agents for super-Resolution Imaging and seNsing' to be submitted under Horizon Europe.

assistant: **Abstract**

Since Alzheimer disease (AD) affects up to 50% of individuals above 85, we will witness the three-fold increase in the number of patients by 2050 if no efficient therapy will be found. The FLORIN offers non-invasive real-time monitoring of key mechanisms involved in the AD pathogenesis by avant-garde bioimaging at temporal resolution less than 1 millisecond and spatial resolution 20 - 50 nm combined with the simultaneous all-optical thermal control with 20 mK accuracy. FLORIN relies on three pillars.(1)super-resolution optical fluctuation image scanning microscopy (SOFISM) and photon antibunching contrast enhanced super-resolved optical imaging (Q-ISM), providing accurate real-time information on fluorescent nanoparticles delivery, their organelle-specific targeting on the molecular level, and intracellular distribution with spatial resolution below 20-50 nm;(2)frequency upconverting quantum emitters that enable convert excitation in the tissue transparency window (from 650 to 1350 nm) to fluorescence in visual spectral range;(3)biosensing techniques capable to detect tiny changes of temperature in the living tissue with 20 mK accuracy.With its vision for the project and beyond, FLORIN will facilitate the further development of the devices for the clinical diagnosis and treatment of AD, being fully in line with the EU Joint Programme – Neurodegenerative Disease Research and  contributing to UN Sustainable Development Goal “To Ensure healthy lives and promote well-being for all at all ages”.Uniting 6 well-recognized academic partners from EU and Canada, and 3 hi-tech SMEs, ATOMICUS (Germany), Adamas (USA) and Platformina (Lithuania), FLORIN action as a part of the ‘biophotonics and quantum sensing’ flow will contribute to the rise of the potential of individuals and impr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of a new female contraceptive device'.

assistant: **Concept**

Sterilization of women by surgical occlusion of the fallopian tubes remains the most popular of modern contraceptive methods; Current estimates suggest that more than 140 million eligible couples rely on female sterilization to avoid further pregnancies (WHO 1995). Up to the present the most commonly used surgical procedure is a transabdominal minilaparotomy. Major drawbacks of this technique are the costly instruments required for laparoscopy, the need for adequate anesthesia as well as post-operative pain relief, and the training needed for delivery of services; The need for non-invasive reversible sterilization techniques to reduce the risk, cost, patient discomfort and morbidity associated with surgical sterilization is widely recognised. The objective of this project is to develop a sterilization technique that will reduce the risks and costs of surgical sterilization procedures and provide women with the option of an efficient and potentially reversible form of birth control. In the project we will develop and evaluate a transcervical intratubal contraceptive device which can be placed without anesthesia under plain ultrasound guidance or by tactile impression. We will incorporate recent developments in the field of ultrasound and tactile guided tubal cannulation in the delivery system, resulting in a design that will allow atraumatic insertion and will be as independant of skill as possible and practicable for service delivery in an office setting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bringing to the market a new generation of AI-powered Media Monitoring Tools' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Media Monitoring is the systematic recording of media output related to a specific target, its activities and topics of interest. With the galloping growth of sources, many media monitoring companies have addressed this issue by increasing human resources. However, human expertise which should be focused in advanced analysis is being wasted on time-consuming mechanical tasks.Current commercial solutions peddle the use of “Artificial Intelligence”, but they are still highly dependent on human expertise to filter out irrelevant content. The worldwide market for media monitoring is valued at US$2.23 bn (2017), with a CAGR of 13,6% until 2022.Building on 3 years of cutting-edge AI research funded by H2020, Priberam is developing a real-time crosslingual global media monitoring platform that delivers actionable insight beyond human capabilities. Our system, based on a scalable SaaS business model, continuously ingests massive multilingual data sources and automatically translates, filters, categorizes and generates reports for media monitoring professionals.MONITIO will be co-created with end-users at Deutsche Welle and improved with cutting-edge technology from Cambridge University, focusing on GDPR and the new EU Copyright legislation, making it the first media monitoring tool copyright compliant-by-design (in opposition to the majority of competitor solutions, which are US-based and not centred in these issues).Priberam is a Portuguese SME that provides cutting-edge Natural Language Understanding and Artificial Intelligence technologies to companies in the media, legal and healthcare industries, and exports its technologies to international top companies such as Microsoft, Amazon, Kobo, and the main media publishers in Portugal, Spain and Brazil. Our team of 24 generated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeting MarA to Inhibit Efflux' under Horizon 2020.

assistant: **Concept**

Antibiotic resistance is a growing global crisis and current predictions suggest that by 2050 drug resistant bacteria will cause up to 10 million deaths a year globally. Bacteria employ many mechanisms to become resistant to antibiotics. One important mechanism is antibiotic efflux where membrane bound efflux pumps actively pump molecules, including antibiotics, out of bacterial cells. The RND-family AcrAB efflux pump confers multi-drug resistance in many Gram-negative bacteria including Escherichia coli and is commonly over-produced in antibiotic resistant clinical isolates. Regulation of RND efflux pump expression is complex but in E. coli the master regulator is the AraC/XylS family global transcription factor MarA. In spite of its relevant role up to now no inhibitor targeting this protein has been published. In this project we aim to develop efflux inhibitors that prevent transcription of acrAB by inhibiting MarA and to test their efficacy by measuring AcrAB expression and activity. In order to design the inhibitors we will analyse MarA structure and its direct DNA interactions based on available crystal structures. We will design oligonucleotides acting as a transcriptional factor decoy that modulate transcription by sequestering MarA from their endogenous DNA binding sites (RO1). We will also design peptides acting as inhibitors by blocking DNA-MarA interactions (RO1). Nextly we will measure the affinity of the inhibitor-MarA complexes by in vitro biochemical assays (RO2) and in vivo experiments (RO3). In RO4, we will crystallize the most promising inhibitor-MarA complexes in order to improve their efficacy after structure analysis. Successful development of these inhibitors will open an avenue in the fight against antibiotic resistance conferred by increased eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'System Identification of the Dynamics of Multisensory Integration', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The central nervous system (CNS) processes sensory information obtained through various sensory structures in the body. These include signals with a wide variety of spatiotemporal features, such as different speed and propagation patterns. In this stream of multimodal sensory information, CNS must decide how it should integrate these signals to construct a unique representation of the environment. How CNS accomplishes this process is not known. In this project, I will investigate the filtering mechanisms adopted by CNS to integrate multisensory information. Specifically, I will study multisensory integration within the context of two unique behaviors: (1) glass knifefish combine visual and electrosensory cues to track the movements of a refuge in which it is hiding, and (2) zebrafish utilize vision and mechanosensory lateral line to sense the direction and velocity of the local current during their rheotaxis behavior. To accomplish this, I will first build a novel experimental setup, a speed-controlled flow tunnel, which allows independently probing different sensory modalities for both the glass knifefish and the zebrafish. I will adopt a control-theoretic approach to identify how CNS combines multisensory information under different sensory conflict scenarios. Specifically, I will estimate the frequency response functions for the sensory weights assigned to different sensory modalities. Moreover, we will observe how CNS dynamically changes these weights when there is a change in the saliency of the available sensory information. Our goal is to use system identification theory to generate models that capture the dynamics of online, real-time sensory re-weighting mechanism adopted by these fish.


**Keywords:** multisensory integration, weakly electric fish, zebrafish,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'OPEn-air laboRAtories for Nature baseD solUtions to Manage hydro-meteo risks' (OPERANDUM), addressing dissemination and exploitation.

assistant: **Impact**

Severe hydro-meteorological phenomena are having a high impact in European territories and are of global concern. The science behind these phenomena is complex and advancement in knowledge proceeds with progress in data acquisition and forecasting useful for real-scenario interventions. The employment of nature-based solutions (NBS) to mitigate the impact of hydro-meteorological phenomena is not adequately demonstrated, still uncoordinated at the European level, therefore not reaching full potential. Actions to achieve highest NBS impact requires strategies to enhance societal acceptance, policy strengthening while demonstrating advantages for market development. The objective of OPERANDUM is to reduce hydro-meteorological risks in European territories through co-designed, co-developed, deployed, tested and demonstrated innovative green and blue/grey/hybrid NBS, and push business exploitation. It aims provision of science-evidence for the usability of NBS, best practices for their design based on participatory processes. It foresees a multiple level of stakeholders engagement from the local community up to the international level to leverage widest possible NBS acceptance to promote its diffusion as a good practice.   It establishes the framework for the strengthening of NBS-based policies according to local legislation and promotes technology and innovation in NBS to create a European leadership. OPERANDUM is based on open-air laboratories (OALs), a fairly new concept that expands the Living Labs to a wider vision for natural and rural areas. In OALs novel NBS in seven European countries and three in China and Australia are implemented to address specific risks and their effectiveness, assessed through innovative monitoring systems and cutting-edge numerical modelling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computer methods to predict three-dimensional hydraulic fracture networks' under Seventh Framework.

assistant: **Concept**

The world's ever-growing rate of energy consumption urges the improvement of techniques of both fossil fuels and renewable energy. Hydraulic fracturing is a technique applied to both categories of energy sources. It consists in pumping water at a very high pressure through pre-drilled wells into the ground and generating fractures in the rock. It can be employed to extract crude oil or natural gas from the rock; it can also facilitate the extraction of heat from the earth by forming a network of underground fractures. Its application requires the design of the fracturing strategy, including the quantity and pressure of the water to be injected.Hydraulic fracturing is expensive to study both on site and in a laboratory and only limited information can be obtained wherefrom. On the contrary, computer simulations are cost-effective and time-efficient in predicting the geometry of the fractures and thus can contribute to speeding the designing process. Nevertheless, most state-of-the-art simulation methods for the fracturing process apply only to a (layerwise) homogeneous rock medium.In this project, I plan to develop efficient simulation methods with the objective of accurately predicting the three-dimensional network of hydraulic fractures, taking into account rock self-contact, inhomogeneity, and poroelasticity. I also plan to build methodologies to incorporate stratigraphic data obtained from field technologies. A technical contribution to the field of numerical analysis will be the use of variational inequalities to incorporate the inequality constraints arising in the formulation of the coupled problem between the fluid and the rock medium.I completed my doctoral study and postdoctoral training at Stanford University, United States. In April 2011, I started a four-yea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'RAS/C-RAF interaction: A new pharmacological target in Kras-driven lung cancer.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Lung adenocarcinoma is the most frequent subtype of lung cancer and patients harbour activating mutations in the KRAS gene in approximately 25% of the cases. Unfortunately, regardless of the outcome of recent studies identifying specific KRASG12C inhibitors, so far, oncogenic KRAS is not a druggable target yet. The best-characterized KRAS effector pathway, the ERK cascade consists of RAF, MEK and ERK proteins that can be inhibited with small molecules targeting their kinase activities. As the development of RAF and MEK kinases inhibitors progressed, feedback loop reactivating the ERK cascade have emerged, inducing resistance to treatment. Thus, new innovative strategies are needed to achieve a more long-term inhibition of this signalling pathway, while reducing detrimental side effects due to MAPK inhibition in normal cells. It has been described more than 20 years ago that RAF directly interacts with RAS through its Ras Binding Domain (RBD), and many research groups have been trying to disrupt this interaction developing allosteric inhibitors as a cancer therapy. At the moment, those molecules need to be improved in order to achieve a strong inhibition of this pathway. Surprisingly, no mouse model actually demonstrates the requirement of RAS/RAF interaction during KRAS-induced lung tumourigenesis. Here, we propose to investigate this crucial question using a new mouse model allowing us to conditionally disrupt RAS/RAF interaction in vivo. Using the leading mouse model to study lung cancer (LSL-KrasG12D/+; p53-/- mice), we will take advantage of both Cre/LoxP and FLIPo/Frt technologies to investigate the role of RAS/RAF interaction during lung tumours maintenance, as well as its function in tumour/host crosstalk and normal physiology. All together, these investigations