RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Photonic Quantum Information Technology and the Foundations of Quantum Physics in Higher Dimensions'.

assistant: **Innovation**

One of the most important developments in modern physics was the recent emergence of quantum information science, which by its very nature is broadly multidisciplinary. It was started by investigations of the foundations of quantum mechanics, and fundamental quantum concepts, most notably, entanglement, play a key role. We are now at an historic moment where a major qualitative step, both in developing a new technology and applying it to new fundamental questions, can be made. In this proposal, we aim to combine the investigation of fundamental questions with the development of micro-optics technology to reach a new level of both quantum information experiments and fundamental tests of quantum mechanics.  We propose to utilize the advanced development of micro-optics to build novel integrated quantum optics photonic chips. High quality micro-optics will allow precise control over many properties, including birefringence, dispersion, periodicity, and even absorptive properties. We will combine this with novel highly efficient detectors, hopefully, in the long run, also integrated into the same microchips.  By their very nature, the new multi-mode devices will make new higher-dimensional regions of Hilbert space and new types of multi-photon entanglement accessible to experiment. Such devices will enable many new fundamental investigations of quantum mechanics, such as, to give just one example, exploring quantum complementarity both between different numbers of photons and as a function of Hilbert space dimension with significant mathematical implications. Most importantly, we are convinced that many new ideas will arise throughout the project.  The new integrated quantum optical chips will also be important in quantum computation, specifically with cluster states and si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Science goes social - sending weak signals from your futures'.

assistant: **Innovation**

Science Goes Social in Turku, the oldest university town in Finland, with an entertaining scientific programme demonstrating the presence of science in everyday life – and envisioning the future, or, Turku Tomorrow . It will remind of the immediate everyday encounters with science through basic demonstrations e.g. in health, virology and hygiene – and explore the more constitutive elements of the human experience such as genetics, ethics, even love. TurkuTomorrow is designed around a grand event held at the brand new cultural centre Logomo.The Awareness Campaign utilises social media in introducing 30 nominated researchers, personally and unmediated. They are presented with individual personal histories and ordinary lives, yet standing out from the crowd in communicating that what they want to learn and what they are able to discover will effectively determine our future. The aim of this personal approach is to provide to a simple, low-threshold channel to mobilise the public to take an interest in matters which the average person normally considers distant, too abstract or the property of experts. The project Facebook page serves as a public opinion forum, where science is made political: it encourages everyone to take a stand on issues related to the ethics and the future of research.Turku Tomorrow offers an experience for all senses: each research station at Logomo is an opportunity to participate personally in experiments, competitions, discussions, and performances. Based on the Awareness Campaign, the Night presents Scholastic debates in the Late Antiquity style, addressing the concerns and dilemmas put to the researchers by the public. All participating researchers will be invited in advance to innovate Weak Signals from their respective fields of expertise. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-channel cooperativity in visual processing' under Sixth Framework.

assistant: **Concept**

A computer with intelligent visual skills comparable to biological ones has been an ambitious research goal ever since the field of computer vision took off some 30 years ago. As an alternative to mathematical approaches, especially when they fall short of their expectations, attempts to mimic the processing of the brain have been pursued, but implementing the result into computer vision systems is still in its infancy. This project envisages the development of biologically-inspired computer vision techniqu es, which exploits the physiology and anatomical connectivity of individual visual neurons and integrates their individual functionalities into cooperative visual systems. Our approach will emphasis the role of the topological organization of visual neuron s with similar functional properties. The novelty of this approach lies in the direct involvement of the neuron's topological organization (spatial layout") for the processing of visual information. Two types of visual neuron functionalities ("channels") will be modelled and integrated: the orientation selectivity leading to selective edge detection and the perception of 3-dimensional motion. These two functionalities will be linked together forming a cooperative multi-channel system for selective object d etection under various environmental conditions. The capability of newly developed computer vision techniques will be tested with images of rapidly changing scenes such as those observed by a car driver. This project is in the rapidly evolving area of biol ogically-motivated computer vision, and at the cross road of computational neuroscience and computer vision. It has a high scientific risk since multi-channel modelling has been tried before, but failed to proliferate computer vision. The project has a sig nifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Smart nondimensional biosensors for detection of tumor cells and cytotoxic amyloids intermediates' in the context of a Seventh Framework call.

assistant: **Objectives**

This project integrates the development of (a) bioconjugated silicon nanoparticles (NPs) as new, < 3nm, fluorescent probes and (b) dual-emission band fluorescent biosensors for protein conformation investigations to be applied in diagnostic procedures related to tumor biology and neurodegenerative diseases. Epidermal growth factor receptor (EGFR) is an important therapeutic target in a variety of tumors, particularly malignant gliomas where mutation and/or amplification of EGFR is often observed. The laboratory has demonstrated in a pilot study the specific binding of biomolecules conjugated to Quantum Dots to patient-derived glioma spheroids.  High wavelength emitting QDs are necessary to distinguish binding from tissue autofluorescence but such QDs are large (~40 nm) and do not penetrate deeply into tissues or access cellular junctions.  The project will develop smaller, more inert, and less toxic conjugated silicon nanoparticles that can ultimately be used for the detection of residual glioma cells in patients after surgical resection. Additionally, more complex composite nanoparticles that selectively internalize in the tumor cells will be investigated as vehicles for drug delivery or selective killing. The aggregation of proteins and peptides is a fundamental feature of neurodegenerative diseases such as Alzheimer’s, Parkinson’s and spongiform encephalopathies. It is not clear whether the fibrillar aggregates or smaller forms of the implicated proteins are the cause of cytotoxicity. Both in vitro assays and in vivo studies are hampered by the lack of probes that can distinguish and quantitate early stages of the aggregation phenomenon. This project will develop fluorescent biosensors for protein folding on the basis of environment sensitive ratiometric dyes that ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Most cost and time efficient EU-wide cross-border automated parcel delivery solution' (CLEV), addressing dissemination and exploitation.

assistant: **Impact**

Cleveron has developed the most modern and efficient automated parcel delivery solution (APDS) in the world – lowered delivery price by 50% and granted seamless, easy to use service. The project’s vision is to develop and implement EU-wide APDS that will offer high efficiency and exceptional consumer satisfaction in cross-border parcel delivery (in a fast growing €4bn e-commerce market). Cleveron’s main innovation is to use existing key success factors (optimisation algorithms, collaboration with stakeholders, integration into the value chain, and use of custom designed parcel lockers) and create international information infrastructure for e-retailers, consumers and collaboration of parcel terminal networks, carriers, individual carriers, and logistics service providers along value chains. Innovation project results (APDS technologies/services) serve interests for all stakeholders by decreasing delivery costs by 50%, allowing international next day delivery and improve vehicle load rates. Phase I (feasibility study) will determine early adopters, specifications and requirements for phase II, and specifics of different EU countries, elaborating development plans for phase II. Phase II will involve the implementation of EU-wide APDS pilot. By the end of Phase II, early adopters will become a part of the business model (partners) or paying customers. Phase II budget is estimated to be €3.6m.This project will drive drastic improvement in efficiency and load rate of vehicles in the EU logistics sector. As a result, new high value added jobs in transportation sector will be created. After proven performance in the EU, APDS technologies/services could be applied worldwide and/or to more value chains where efficiency can be improved. Fostering efficiency improvement in transpo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Synthesis of Truncated Tirandamycin A-D Derivatives as new Antihelminthic Agents' under Horizon 2020.

assistant: **Concept**

This project entitled “Synthesis of Truncated tirandamycin A-D derivatives as new Antihelminthic Agents (STTDAA)” aims at developing novel asparaginyl tRNA synthetase (AsnRS) inhibitors as potential antihelminthic agents, with new mechanisms of action for potential treatment of lymphatic filariasis (LF). LF is one of the World Health Organization’s (WHO) top 10 neglected tropical diseases (NTDs), This incapacitating disease has infected over 200 million people in 73 tropical and subtropical countries, while more than 1.4 billion people remain at the risk of infection. Thus a top priority of the WHO is to search for new antihelminthic drugs that kill adult worms (macrofilaricides), have new mechanisms of action, and exhibit fewer side effects than currently available medications such as albendazole and ivermectin to which parasite resistance has already been confirmed.To this end, two distinctively different but complimentary synthetic approaches towards tirandamycin A-D (TAMs A-D) derivatives, as AsnRS inhibitors will be developed. This will be followed by intensive structure activity relationship (SAR) studies, which will further promote improvements of the bioactivity and the drug characteristic of the synthesized derivatives. These studies will compose a vital part of a more comprehensive drug development program.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimised microturbine energy systems' (OMES).

assistant: **Concept**

- To obtain energy savings and reduced emission through use of micro gas turbines in different CHP applications, including SME's.- Validate data on performance, energy efficiency, availability, emission etc. during practical operation for the only European-made micro gas turbine.- To develop and demonstrate cluster installation of microturbine CHP units.- Demonstrate multi-fuel capacity including bio fuels and fuels with low heating value (down to approx. 5kWh/m3n).- To develop and demonstrate flexible steam production by micro gas turbine.- To demonstrate advantages with direct drying and/or the use of flue gas for fertilization purposes.-To demonstrate small-scale CHP at remote locations.-To ensure European knowledge and commercial participation in the field of development, production and implementation of micro gas turbine based CHP.-European estimation of microturbine based CHP potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The evolutionary epidemiology of commensal bacteria: the case of Escherichia coli from 1980 to 2025' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding the rapid adaptation of infectious pathogens is crucial to design better management policies and anticipate future changes. Yet, existing models often fail to explain these dynamics. I will address this major challenge of evolutionary biology in the bacterial species Escherichia coli. E. coli is a commensal of the human gut and an opportunistic pathogen causing infections responsible for more than a million deaths worldwide per year. E. coli has rapidly evolved over the last four decades. From the 1980s, starting from an almost fully sensitive population, multiple antibiotic resistances have emerged and stabilised at an intermediate frequency. Concomitantly, virulence, the propensity to cause infections, increased. The evolutionary processes causing these changes are largely unknown. To elucidate the drivers of the evolution of commensal E. coli, I will develop a prospective cohort of 200 longitudinally followed healthy volunteers—the largest cohort of its kind. We will analyse these data in the light of an integrative statistical and mathematical framework describing the ecology of E. coli from the within-host to the population level. These models will generate testable predictions on the evolution of genomic variants determining virulence, resistance, and colonisation ability. These predictions will be validated on an exceptional existing dataset composed of 1000 bacterial genomes sampled from healthy human hosts from 1980 to 2025 encompassing around 100,000 generations of bacterial evolution. This original interdisciplinary framework draws from epidemiology, evolutionary biology and genomics for a better understanding of the evolution of bacteria. This project is a step towards better predictions of evolutionary dynamics and better stewardship policies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Competence Centre on POLYmer MICROoptics'.

assistant: **Innovation**

The goal of the proposal is to set-up a competence network with technology development support centres in Germany, UK, Finland and Israel with the aim to assist European industry in their activities to develop and manufacture polymer micro optical components and micro systems. This takes into account the increasing importance of polymer fabrication technologies especially in micro optics and helps to make use of this low cost fabrication technique for a broad range of European companies, especially SMEs. The network covers the full chain necessary to develop and manufacture polymer micro optical systems, starting from materials question, via simulation and product development as well as process and process equipment development to feasibility studies and prototyping up to small series fabrication. It also includes housing and packaging issues.Objectives:The objective of this proposal is to increase competitiveness of European Industries in the area of polymer micro optics by the Competence Centre POLYMICRO, which assists European companies in making use of the low cost polymer fabrication technology as well as of polymer micro components to build up new and improved micro optical systems in areas like telecommunication, medical diagnostic, personal identification as well as in the wide area of micro sensors. Thus, the competence Centre will contribute to the economic development of the European Community by promoting the use of micro system technology with low cost polymer devices mainly in industry. It will decrease the entry to this emerging technology especially for SMEs.Work description:The workplan with 10 workpackages is designed to ensure a maximum support to European industry which enables them to decide about the use of polymer fabrication technologies as well
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Plasmon Coupled Luminescent Solar Concentrators and their Application in Self-Supplied Electrochromic Windows'.

assistant: **Innovation**

Luminescent solar concentrators (LSCs) have the potential to facilitate widespread deployment of building-integrated photovoltaics (BIPV) into our cities. However, prototype devices still fail to achieve the theoretical efficiencies due to contributions from optical loss mechanisms, including light scattering. The aim of PLECTRA is to understand, control and harness the contribution of light scattering mechanisms to design efficient LSCs that can be used in BIPV. The phenomenon of plasmon-enhanced photoluminescence, in which elastic scattering from plasmonic nanoparticles boosts the photoluminescence efficiency of a luminescent species (e.g. quantum dots), will be exploited to harness scattering and improve the LSC performance. To achieve this we will use a layer-by-layer deposition approach to prepare resonator-emitter core-satellite structures, in which the two species are separated by a quantifiable distance. Single particle scattering and photoluminescence studies, will be used to determine the required separation to obtain plasmon-coupled photoluminescence (rather than quenching). Optimised species will be incorporated into LSCs and sophisticated angle-resolved scattering measurements, in conjugation with numerical simulations, will be used to evaluate the scattering pathways in the device. Finally proof-of-concept integration of the LSCs with PV cells, and subsequently electrochromic glass will be demonstrated as evidence for potential application in BIPV.


**Keywords:** plasmonic nanoparticles, luminescent solar concentrators, nanocomposite materials, angle-resolved scattering, single particle scattering, electrochromic devices
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Freeze Control in Food by Ice Binding Proteins' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The freezing processes play a main role in food science. The storage of food in a frozen form has become one of the most common ways to elongate the shelf-time of many food products. Nevertheless, during freezing and thawing, cell walls can be ruptured by the ice crystals or can be separated by extra-cellular ice growth during the recrystalization process. Ice binding proteins (IBP), which include antifreeze proteins, ice nucleating proteins, and recrystalization inhibitors, hold great promise for improvements in food supply and quality through the prevention of frost damage to crops and the enhancement of preservation technology. The interaction of IBPs with ice crystals suggests that these proteins can be use as a means of controlling ice in food in each level of its production and processing. I propose to investigate freeze control in food by ice binding proteins. My background includes a PhD in ice physics and in particular optical investigation of crystal growth, a post-doctorate work in biophysics and biotechnology and academic position in Ohio University in where I investigate IBPs. In my post-doctorate work at Caltech, I developed instrumentation that was the basis for the biotechnology company Helicos Bioscience, which led to the development of the first instrumentation that can sequence DNA at the single molecule level. In the past few years at Ohio University, I have combined the subjects of ice physics and biophysics and have developed methods for investigating antifreeze proteins in novel ways. I have developed unique instrumentation to assess the activity of the proteins, in particular microfluidics and fluorescence microscopy. At the Hebrew University Faculty of Agriculture, Food and Environment I intend to establish a Food Biophysics lab in which I will