RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How cellular suicide programmes control phase transitions in fatty liver disease and liver cancer' in the context of a Horizon 2020 call.

assistant: **Objectives**

The progression from a healthy liver towards non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) serves as a model for chronic diseases in a solid organ, demonstrating how an initially stable stage undergoes critical transitions along several defined phases. Defining the molecular drivers of these phase transitions will open the road for the definition of warning signs, risk prediction approaches and prevention of disease decompensation in human liver disease. We recently made several ground-breaking findings indicating that the molecules RIPK3 and MLKL – which regulate a novel form of programmed cell death called necroptosis – are crucial mediators of these phase transitions, but they might have unexpected and cell-death-independent functions. Therefore, PhaseControl aims at exploring the specific functions of these molecules at the critical phase transitions towards NASH/HCC. Specifically, I propose to apply a systematic approach and innovative methods to 1) explore cell-type specific RIPK3- and MLKL-dependent regulatory networks in white adipose tissue (WAT), hepatocytes and myeloid cells in murine NASH development and define cell-death independent functions of MLKL in metabolic regulation;2) explore how inflammatory pathways in hepatocytes modulate the reactivity and specific responses   towards necroptosis at the transition towards hepatocellular carcinoma (HCC);3)  examine apoptosis- and necroptosis-specific genetic alterations and driver mutations that mediate the   transition from chronic inflammation to HCC; 4)  evaluate in a cohort of human patients if these newly discovered pathways can be used for risk-prediction approaches and might be chemoprevention targets against HCC.The expected results will establish a novel concept how programmed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Conquering a New Paradigm for Addressing Ion Detection in Real Scenarios'.

assistant: **Innovation**

ConquerIons is seeking a definitive solution for the detection of ions in real scenarios by innovatively addressing the limitations of traditional ion-sensing concepts in terms of effectiveness, sensitiveness, robustness and downscaled platforms. The project proposes a new generation of voltammetric, amperometric and optical ion sensors based on calibration-free selective membranes inspired by conventional membranes used in the well-established potentiometry field but with a thickness at the nanoscale. The uniqueness of the dynamic electrochemical tuning of ion-transfer processes across these nano-membranes opens up a revolutionary approach that allows for the monitoring of ion concentration in a sample with unprecedented analytical performance. Thus, the project combines efforts from the synthetic chemistry, material science, nanoscience, electrochemistry and analytical chemistry disciplines resulting in a universal concept for the reliable detection of ions. ConquerIons is based on a research approach carefully designed mainly considering the following challenges: (i) the use of novel materials to afford a robust and universal detection; (ii) the implementation of thin-layer concepts of electrochemical and/or optical-sensing platforms to achieve reduced limits of detection and calibration-free methodology; (iii) the translation of the developed concepts to the single-entity scale (i.e. single nanoparticles) towards the study of ion-transfer processes employing, for the first time, ‘nanocoulometry’ readout; and (iv) exploitation of sensors from the laboratory context based on relevant cases as the next step towards the final use as daily smart informers operating in real scenarios. This latter purpose will lead to a series of extraordinary analytical applications from
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart Tanks for Space' (SMARTTS), addressing dissemination and exploitation.

assistant: **Impact**

Satellites constitute a major element of critical infrastructure for most industrialised countries. Virtually all commercial, infrastructure, and scientific satellites carry one or more tanks, for fuel, oxidiser, or coolant. There is no in-orbit method of accurate establishing fluid reserve mass in a tank. Book-keeping methods are employed to track fuel usage, with ever- increasing error, and conservative margins are applied to ensure reserves for end-of-life disposal compliance. Further, fluid slosh presents a challenging control problem - reducing pointing accuracy and introducing potential resonances that threaten platform safety.Atout Process Ltd. (‘Atout’) is a European SME founded in 2010 to develop innovative products based on non-intrusive electromagnetic imaging and measurement techniques. Atout has commercialised a novel monitoring system for the oil and gas, power generation, food and drink and other industries.This project will establish the commercial potential for spin-in to the space sector of Electrical Capacitance Tomography (ECT) for accurate real-time measurement of fuel mass and slosh torque vector. A proof-of-concept demonstrator project has already been completed, and a further refinement to TRL6 is nearing completion.Our industry discussions and analysis to date suggest a strong potential for the technology to extend mission lifetime and improve attitude and orbit control efficiency, yielding a major impact on spacecraft performance. For a geostationary communications platform, this directly translates into substantial commercial benefit to the operator/owner, extending lifetime by up to six months and reducing risk. This proposal explains the business opportunity, technology status and development roadmap, and the specific impacts that H2020 fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Methods and Tools Supporting Digital Product Service System Passport'.

assistant: **Concept**

Modern industrial companies aim to extend their products with services as fundamental value-added activities. The key potential of the concept of Product Service System (PSS), besides radical improvements in the use of products, is a reduction of environmental footprint of products and services. The overall footprint of PSS is still insufficiently investigated. The services within PSS are an important, insufficiently used source of (digitalized) data on the product and its use. It is likely that digital means facilitating provision of consistent “track and trace” information on the origin, composition and entire life cycle not only of a product but of all services offered and used around the product, will offer important contribution towards achievement of full circularity for manufacturing. The key idea of PSS-Pass is to investigate how extension of DPP to Digital Product Service System Passport (DPSSP) can be effectively achieved and how it will allow for improved circularity of the manufacturing industry. The overarching hypothesis is that LCA underpinned by Machine Learning (ML) methods and informed by dynamic data paves the way to more accurate LCA while supporting PSS life cycle decision making. The collected and sharable data from DPSSP will allow to effectively apply ML as well as Digital Twin (DT) for more reliable decision-making processes concerning circularity of PSS. The project will provide Methodological Framework for definition, development and update of DPSSP, Digital Environment for DPSSP built on existing interoperability architectures, set of ontologies for improved interoperability at DPSSP Environment, novel DT-based Simulation Framework, for modelling standardized and interoperable DTs for PSS lifecycle analysis, and AI based method/tool to foreca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification and characterization of novel genes involved in DNA damage- response pathways in humans' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

DNA damage induces cell cycle arrest, required for the action of repair mechanisms. The genes of these pathways affect cells' sensitivity to DNA damage, and their loss may lead to deregulated cellular growth, genomic instability and cancer. Until now, our knowledge in this field was gained mainly from work in cells of DNA damage-sensitive individuals and from lower eukaryotes. Improving our understanding of these processes in mammals was hampered due to lack of suitable genetic tools. Recently, we developed a vector-based system that generates persistent loss-of-function phenotypes in mammalian cells by production of short interfering RNA (siRNA). A siRNA-expressing library to suppress up to 8000 human genes was constructed in our institute and is consent to perform genome wide loss-of-function screens.The proposal includes:1) Screen for novel genes participating in DNA damage response pathways;2) Elucidating the roles of these genes in DNA damage response pathways;3) Evaluating the contribution of these genes to malignancy.I will screen primary human cells for genes involved in sensitising cells to genotoxic stress, and genes that synergize with radio- and chemotherapy agents in tumour cell killing. I will investigate the mechanism of action of the identified genes in DNA damage response pathways, and will assess their tumour suppressive/oncogenic properties. The identification of novel genes modulating cellular toxicity induced by DNA damage will improve our understanding of the action genotoxic agents, and will provide new opportunities to screen for drugs that sensitise tumours to conventional therapy.This project will render the siRNA library system extremely beneficial for mammalian models and research fields, encouraging the transfer of research competencies acro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cooling with Electrocaloric Polymers' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cooling our food and houses requires today 20 % of all the energy needed in the residential sector. This share will grow to 40 % by 2040 as a direct consequence of the world population increase and the global warming effect. But the existing cooling technologies are overwhelmingly dominated by the vapour-compression systems, which is a 150 years-old technology relying on greenhouse gases and exhibiting an average efficiency around 50 %. The latter figure means that half of the energy used to run fridges and air conditioning ends up in waste heat. We clearly need to come up with cleaner and more efficient cooling principles. Electrocaloric cooling has become a more and more realistic alternative to vapour compression cooling. This principle is based on a reversible variation of temperature induced in specific materials when voltage is applied. LIST recently showed that a few grams of electrocaloric ceramics can generate a variation of temperature of 20.9 K and a cooling power of 4 W. Besides, electrocaloric polymers have a cooling potential one order of magnitude larger than ceramics. This is what we intend to develop in this project, with a clear assessment of scale up capabilities thanks to an ad hoc consortium. Hence, Arkema, world leader in electroactive polymers, will investigate electrocaloric polymers able to reach a variation of temperature larger than 5 K. KEMET, European industrial partner, will prepare thousands of multilayer capacitors based on optimized electrocaloric polymers. The PI from USTUTT, who recently published the most efficient energy recovery circuit for electrocalorics, will build electronic modules able to increase the efficiency of electrocaloric devices up to 60%. And finally, thanks to its extensive experience in making electrocaloric cooler
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel Echoes. Ancient Novelistic Receptions and Concepts of Fiction in Late Antique and Medieval Secular Narrative from East to West' (NovelEchoes), addressing dissemination and exploitation.

assistant: **Impact**

This project offers the first comprehensive reconstruction and interpretation of receptions of ancient novels (1st-4th cent. AD) in (Greek, Arabic and western vernacular) secular narrative from Late Antiquity and the early Middle Ages. Novel Echoes follows up from the ERC Starting Grant project Novel Saints (on hagiography). It does so by taking ancient novelistic receptions towards entirely new, unexplored horizons. Our knowledge about the early history of the novel is incomplete. Receptions of ancient novels have been studied for periods from the 11th and 12th cent. onwards but not systematically examined for preceding eras – much to the detriment of the study of both narrative (then and later) and the history of fiction. This project pursues the hypothesis that different secular, narrative traditions in this period were impacted (directly or indirectly) by ancient novelistic influences of different kinds and adopted (and adapted) them to various degrees and purposes; and that, since the ancient novel is a genre defined by its own fictionality, its reception in later narrative impacts notions of truth and authentication in ways that other (often more authoritative) literary models (e.g. Homer and the Bible) do not.Novel Echoes strikes a balance between breath and depth by envisaging three objectives:1. the creation of a reference tool charting all types of novelistic influence in secular narrative from the 4th to the 12th cent.;2. the in-depth study of particular sets of texts and the analysis of their implicit conceptualizations of truth, authentication, fiction and narrative;  3. the reconstruction of routes of transmission in both the West and the East.Given the project’s innovative focus, it will enhance our understanding of both the corpus texts and the early his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Fast, cost-effective, user-friendly point of care (POC) instrument for detection of respiratory pathogens, including Streptococcus pneumoniae'.

assistant: **Objectives**

Molecular techniques such as PCR (polymerase chain reaction) are becoming increasingly used for the detection of respiratory pathogens, due to their high accuracy and relatively fast turnaround time (hours). Their utilization can result in early and specific treatment, contribute to better patient outcomes and reduce length of hospital stay. However, implementation of rapid molecular diagnostics remains limited to large, centralised laboratories which can afford the requirements of dedicated PCR laboratory space, specialized personnel and costly equipment and consumables. Even in central laboratories, timely diagnosis may be undermined by delays during sample transport to the setting and batching practices oriented to save consumables. There is a need for a fast, cost-effective, user-friendly molecular diagnostic point-of-care (POC) instrument for near-patient use at small to medium size hospitals, and decentralized clinical laboratories. The RESPOC platform will be a novel solution designed to detect bacterial and viral respiratory pathogens in less than one hour. Based on the development of DNA extraction and DNA amplification methods integrated into a low-cost microfluidic lab-on-a-chip (LoC) consumable, the platform will deliver results automatically by insertion of the disposable LoC into a small footprint reading instrument. Initially it will identify the target respiratory pathogens Streptococcus pneumoniae (pneumococcus) and Bordetella pertussis. Pre-clinical validation and demonstration of the RESPOC instrument will be performed at the facilities of the RTD hospital participant and at the facilities of the SME end-users to ensure adequate diagnostic performance and usability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Curing polyester resins on demand', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The proposal concerns the development of a new curing technology of polyester resins. Curing of resins are done with thermal heat, UV-radiation or electron beam radiation. The thermal process is the most common in the industry. UV is now starting in appli cation and e-beam curing is still under development. The thermal curing occurs in metal forms and is best suitable for mass production. For huge parts like ship bodies curing takes too long time, because a long curing time is necessary for filling the for m with resin. A thermal activtaion is not feasible. Microwaves of a frequency 2,45GHz ensures a volumetric heating of the resin and overcomes the bad thermal conductivity of the polymer. The microwaves are absorbed from the resin, heated up and starts cro ss-linking. Over the thickness a homogenous temperature profile and also cross-linking profile is achieved. With microwave curing a separation of the filling porcess with resin and the curing process is perormed. Benefits for the product are, curing is n ot dependent on boundary condition like outside temperature humidity and therefore more reproducible and controllable, homogenous curing of thick parts; acceleration of the curing, shortening of the curing time; increase of degree of cross-linking, reduc tion of waste and environmental pollution; lower viscosity of the resin is possible leading to higher fibre content. Social benefits are less VOC emission and drastically decreasing the content of hazardous peroxides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tandem Electrodeless Plasma Thrusters for Universal and Versatile in-Space Propulsion' (NEPTUNE).

assistant: **Concept**

Highly versatile and easy-to-integrate space propulsion will unlock a new stage of the conquest and exploitation of space. NEPTUNE aims to assess the innovation potential of the ‘Magnetic Arch Tandem’ (MAT) thruster concept, which consists in pairing two electrodeless plasma sources to form an innovative closed magnetic topology for plasma jet acceleration. The MAT can operate with any propellant gas; it is simple, durable, and promises a wide operational envelope; has zero net magnetic dipole, and a lower plume divergence angle than its direct competitors, making it easily integrable in present and future space applications. NEPTUNE pursues 4 objectives: (1) optimize the magnetic arch configuration, (2) define an efficient propulsion system architecture using commercial-off-the-shelf (COTS) components where feasible, (3) engage industry stakeholders to assess market viability and explore partnerships, and (4) establish a plan for technology development and commercialization. To achieve these goals, the project will develop a breadboard MAT prototype and conduct high-vacuum chamber testing to find configurations that maximize the key propulsive performance indicators. Testing various propellants will demonstrate operational flexibility. Concurrently, a system architecture study will evaluate power electronics, fluidics, control, and structural subsystems to identify integration and optimization opportunities. Consultation with space agencies, satellite owners and integrators, and propulsion manufacturers will define key performance requirements, gauge market interest, and identify R&D partnerships. The project will protect key innovations, outline a technology maturation roadmap, and explore business models for its ulterior commercialization.The success of NEPTUNE will