RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photo-Fenton degradation of Persistent Organic Pollutants present in Real Contaminated Waters using Solar pilot plant Reactors' in the context of a Horizon 2020 call.

assistant: **Objectives**

In 2009, Lindane was included in the Stockholm Convention on Persistent Organic Pollutants (POPs) to achieve the global elimination of these substances. This international treaty mandates an irreversible destruction of POPs into non-POPs. Consequently, development of cost-effective, safe and environmentally technologies for the destruction of POPs is necessary. Although the Advanced Oxidation Processes (AOPs) are efficient in the treatment of this pollutants, many have the disadvantage of their high cost. A very useful alternative from the economic and environmental point of view is the use of solar energy integrated to these processes. This is Solar photo-Fenton Process (SPFPs).A detailed study associated with the photo-Fenton degradation of POPs (Lindane) present in real contaminated waters using a pilot plant Solar Reactor (SR) is proposed. This development includes an experimental work and rigorous mathematical modelling of photochemical reactors (laboratory and pilot plant scale), considering the fundamentals of chemical reactions (reaction mechanisms) and transport phenomena (mass and energy). The contaminated waters will be obtained at the Bailin landfill Sabiñánigo (Spain).  The propose project addresses an environmental issue, highly relevant for current EU policies, included in UN Sustainable Development Goals, point 6 “Clean Water and Sanitation”.The innovative non-concentrate SR proposed aims to provide an economical/efficient alternative solution to this problem. This technology development would be used for many industries or communes that require an efficient treatment of their effluents. Based on the SR proposed, and considering the results obtained, the patent of these unit will be evaluated.The proposed realistic/highly ambitious work plan will be cons
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Autonomous Patch for Real-Time Detection of Infectious Disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The A-Patch Research & Innovation project will research, innovate, push technology barriers, and demonstrate innovative use of Flexible and Wearable Electronics in the medical and well-being sectors, validate its prototype devices in lab and hospital environments (TRL 4-5). Industrial exploitation of the A-Patch applications will be clearly identified. The project will develop non-invasive autonomous wearable diagnostic patches for real-time remote monitoring of infection status. The A-Patch will use a novel intelligent hybrid sensor array with multiplexed detection capabilities to detect disease-specific volatile organic compounds (VOCs) from the surface of the skin, enabling rapid and highly-accurate diagnosis using a small device. Product innovations for professionals and consumers will be incorporated, and benefits demonstrated. Integration of electronic devices in connected wearable, flexible and stretchable settings, low-power interconnection, compatibility with low-cost manufacturing, efficient energy scavenging and storage, functional performance, and durability will be successfully demonstrated. To ensure reliability and enable extended usage periods, the sensor array will be self-repairing and the device will be self-powered, by advancing cutting-edge research on chemical hybrid sensors and materials. A-Patch will incorporate secure transmission to enable privacy-ensured diagnosis monitoring by physicians, national health systems and worldwide health organisations. The project partners include a health-maintenance organisation, a diagnostic test implementer with in-depth understanding of end-user needs, technology developers, academic / research institutes and a system integrator. The project is planned for a 36-month duration and is estimated to require total
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mutation rate determinants across cellular and evolutionary scales' in the context of a Horizon Europe call.

assistant: **Objectives**

As individuals age, mutations accumulate inexorably in their cells, playing a key role in evolution, ageing, and disease. Despite their importance, we still have a poor understanding of how mutations originate, or why some cells accumulate more mutations than others. This proposal aims to address these fundamental questions by examining two axes of mutation rate variation: among cell types and across species.In Aim 1, we will decode the rules of germline mutation during mammalian spermatogenesis. Cells in the germline exhibit mutation rates significantly lower than those in the soma, through mechanisms that remain unknown. Leveraging recent breakthroughs in long-read DNA sequencing, we will track the accumulation of mutations from spermatogonial stem cells to mature spermatozoa in mice. By integrating this data with existing cell type-specific profiles of gene expression, epigenetic marks, and chromatin architecture, we will delineate how cellular processes influence mutation rates in the germline, aiming to reveal differences with patterns in the soma.In Aim 2, we will characterise the DNA damage response across primates. Recent findings suggest that longer-lived mammals have lower somatic mutation rates, but the underlying mechanisms remain elusive. To tackle this question, we will experimentally expose primary fibroblasts of ten primates to UV radiation and a promoter of oxidative stress, quantifying the impacts on cell viability, gene expression, genome accessibility, and mutation rates and spectra. With this comprehensive approach, we will disentangle the pathways leading to damage-induced mutations, as well as uncover molecular mechanisms that evolution has wielded to select for healthier, longer-lived primates.In summary, this proposal aims to learn about how mut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Structure/property relationships in polycatenar transition metal liquid crystals'.

assistant: **Objectives**

Research objectives and content The project is a systematic examination of structure/property relationships in metallomesogens substituted with several peripheral chains. It seeks to examine the relationship between the liquid crystal properties of silver complexes of poly(alkoxy)stilbazoles and related complexes of palladium and platinum. This study will identify the interdependency of lateral chains and intermolecular ionic interactions in the formation of columnar, nematic and the rather rare cubic phases. In this last case, further systematic information will arise on factors affecting promoting these fascinating phases. This work is primarily synthetic in nature, also developing skills in liquid crystals. The develops to more classical 'discotic' liquid crystals of bis(stilbazole)bis(acetylide) complexes of group 10 metals, investigating possibilities of in-mesophase polymerisation via photochemical (2+2) cyclisations. The polymerised structures will have regular, stacked arrays of metal atoms and will therefore be studied as low dimensional conductors. Training content (objective, benefit and expected impact) The project allows the applicant to become familiar with new synthetic chemistry, and skills in many aspects of liquid crystal science. Expertise will be gained in optical microscopy and calorimetric studies, in addition to X-ray measurements. The twoyear programme will develop skills in the topical area of Materials, providing a base from which to seek permanent employment. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Harnessing a novel CRISPR nuclease for programmable counterselection in human cells' (CRISPR-SELECT).

assistant: **Concept**

CRISPR technologies have revolutionized genome editing in medicine, agriculture, biotechnology, and life-sciences research with their ability to generate virtually any DNA edit at any genomic site in any organism. However, editing frequencies can be restrictively low, requiring extensive screening to identify cells harboring desired edits. What remains elusive is a way to greatly boost the frequency of editing. While characterizing CRISPR-Cas systems, bacterial defense systems and the source of CRISPR technologies, we discovered a new mechanism that could kill unedited cells yet spare edited cells, regardless of the type of gene edit. This versatile and sequence-specific approach can be described as programmable counter-selection, as undesired cells are targeted for removal, and those cells can be targeted in a programmable way. If proven, this capability could radically boost the effective editing frequencies by removing unedited cells regardless of the underlying edit, providing much-needed relief to the burden of screening imposed on diverse genome-editing applications. Here, we propose to perform proof-of-concept experiments demonstrating this capability in human cells while exploring which editing applications would best benefit from this capability. The associated tasks build on my extensive work at the interface of CRISPR biology and technologies and leverages his numerous academic and industrial contacts. I ultimately aim to translate a novel biological insight from my group’s ERC Consolidator project into an innovative foundational technology, with a clear path toward its broad use in genome editing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ploidy change as a rapid mechanism of adaptation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Fungi are particularly challenging pathogens; because they and their human hosts are eukaryotes. We will study how new traits such as drugR arise rapidly using Candida albicans, the most prevalent fungal pathogen of humans. The work explores the ground-breaking concept that alterations in genome ploidy are prevalent in drugR isolates because these genome states promote persistence and drug resistance.We recently found that C. albicans, thought to be an “obligate diploid”, can form haploids. This represents a major paradigm shift both technologically and conceptually. We are poised to exploit this unique opportunity to reinvent genomic approaches for C. albicans by leveraging next generation sequencing, high throughput analyses and more traditional genetics. Because haploids are much less fit than heterozygous diploids, our working hypothesis is that changes in ploidy, including whole genome ploidy and aneuploidy, occur frequently under drug stress and that they make major contributions to the rapid appearance of genotypic and phenotypic diversity, in part by promoting persistence.The objectives of this proposal are to develop next-generation technologies that leverage haploids; to characterize the conditions and genes that promote ploidy transitions, especially in the presence of drug, in vitro and in vivo and to analyze their fitness consequences. This multi-disciplinary research program will integrate = approaches at the genetic, genomic, molecular, cellular and population levels and includes computational approaches to model evolutionary processes.The project will lead to unparalleled advances in tools for the research community, and important insights concerning how diversity arises rapidly. It will assist in efforts to design diagnostic and therapeutic strategies f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Phase Separation and Oscillations in DNA Damage Response' (PHOSCIL) under Horizon Europe.

assistant: **Objectives**

DNA damage response is a crucial function in living organisms, essential for maintaining genomic integrity. Two key processes prevent damage from propagating through generations: 1) DNA repair and 2) regulation of the cell cycle. Recent discoveries reveal that following DNA double-strand breaks, cells form biomolecular condensates at the site of damage through liquid-liquid phase separation. Another hallmark of the response is the initiation of oscillatory p53 concentration leading to cell cycle arrest. Despite being one of the most basic responses in cells, the physical mechanisms underlying this remains poorly understood as does the interplay between repair and regulation. I aim to derive the basic principles for condensates interacting with dynamical and oscillatory concentration fields. Here I will uncover how cells use fundamental mechanisms of physics to control formation and maintenance of condensates and how the emergence of oscillations can facilitate this task.The main highlights of PHOSCIL are the following:Revealing the physical mechanisms and inferring observables of condensate formation, by creating new methods for analysis, guided by theoretical models applied to novel experiments.Discovery of out-of-equillibrium phenomena of oscillatory and dynamic fields and their interactions with phase separation, generating conceptual advances in our understanding of biophysical systems.Uncovering the functional roles of phase sparation and oscillation on both repair and cell cycle regulation, advancing our fundamental understanding of, and ability to influence, cell fate decisions.To succesfully take these ambitious steps, I will combine theory and experiments that, taken together, will uncover novel concepts in the physics of phase separating systems and define a n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy for Smart Objects' (EnSO).

assistant: **Innovation**

The goal of EnSO is to develop and consolidate a unique European ecosystem in the field of autonomous micro energy sources (AMES) supporting Electronic European industry to develop innovative products, in particular in IoT markets. In summary, EnSO multi-KET objectives are:• Objective 1: demonstrate the competitiveness of EnSO energy solutions of the targeted Smart Society, Smart Health, and Smart Energy key applications • Objective 2: disseminate EnSO energy solutions to foster the take-up of emerging markets.• Objective 3: develop high reliability assembly technologies of shapeable micro batteries, energy harvester and power management building blocks • Objective 4: Develop and demonstrate high density, low profile, shapeable, long life time, rechargeable micro battery product family.• Objective 5: develop customizable smart recharge and energy harvesting enabling technologies for Autonomous Micro Energy Source “AMES”. • Objective 6: demonstrate EnSO Pilot Line capability and investigate and assess the upscale of AMES manufacturing for competitive very high volume production.EnSO will bring to market innovative energy solutions inducing definitive differentiation to the electronic smart systems. Generic building block technologies will be customizable. EnSO manufacturing challenges will develop high throughput processes.The ENSo ecosystem will involve all the value chain from key materials and tools to many demonstrators in different fields of application.EnSO work scope addresses the market replication, demonstration and technological introduction activities of ECSEL Innovation Action work program. EnSO relates to several of the Strategic Thrusts of ECSEL MASP. EnSO innovations in terms of advanced materials, advanced equipment and multi-physics co-design of heteroge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transposon-activated Genome-wide search for novel Nociceptors' (TransGeNo).

assistant: **Innovation**

The perception of pain is crucial for our survival, enabling avoidance of harmful physical and chemical insults. Pain initiates in primary sensory neurons, which are highly variable cells innervating the skin, mucus membranes and internal organs. These neurons express combinations of receptor molecules decoding adverse mechanical, thermal and chemical stimuli. Receptor molecules sensitive to these cues decode such inputs into action potentials, which are then relayed to the central nervous system. Uncovering the identity and regulation of these sensory receptor molecules has long been of high interest to the neuroscience community. Being the first point of possible intervention in the signalling process that leads to the perception of pain, therapeutics designed to target these molecules have high promise. Many such receptors have been identified in the past decades. The thermo- and chemosensory TRP channels, intricately involved in our perception of inflammatory pain and injury-induced hypersensitivity, are at the focus of intensive investigations. The recently identified Piezo proteins have significantly advanced our understanding of how sensory nerves decode light touch and proprioception. Many receptors in this system, however, remain to be identified. Among them are mechanoreceptors of painful tactile stimuli, as well as those responsible for the tingling, numbing sensation induced by alkaloids found in Sichuan peppers. Identifying these would open new areas of pain research and provide new, promising targets for analgesic therapy. Here I will employ a new method, Transposon-Activated Genome-wide Screening (TAGS), to identify these receptors. Inspired by the process of evolution, TAGS creates random genetic mutations in vast cell populations and enlists the law of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Quantifying AI-infused Science' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The recent The recent public release of Artificial Intelligence (AI) that can master natural language has sparked a debate about the capabilities of AI and whether it can produce scientific content. Despite the ongoing debate, AI-generated written content has already entered the world of science: Papers co-written by AI are published, companies release models to assist scientists with producing scientific content, and a large fraction of scientists use AI-based tools to augment their writing. We will thus inevitably have AI-infused science in our future. The goal of scAIence is to quantify whether, how, and with which implications generative AI is changing how scientists write, communicate, perceive, and diffuse science, and to rigorously explore the opportunities, dangers, and implications of scientists augmenting their science with AI. The key hypothesis of scAIence is that current AI lacks the ability to combine knowledge entities (e.g. references) in the same manner as humans and is unable to replicate the social information (e.g. homophily or recency) present in human scientific output. Testing the implications of this hypothesis is crucial since the scientific enterprise relies heavily on social information present in scientific output data for a wide range of purposes, e.g. metrics definition, information retrieval, and predictions. The scAIence project will deploy a novel computational social science approach, based on a wide array of quantitative disciplines, leveraging large- scale databases of human-generated information and controlled experiments. scAIence will break new ground by (i) introducing the quantitative methods required to understand AI-infused science, (ii) redefining metrics and models to account for AI-generated content in science, and (iii) del