RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a fully automatic manufacturing system for industria l footwear' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

European footwear industry faces worldwide competitors with old production tools where automation is partly developed. The efficiency of a cycle of production is given by the longest operations manually done and the automation has to be totally organised in order to recover markets share, and win new one. This project has the goal to define a entire automated tool for the industrial footwear. Many companies are concerned in Europe. On top of the development of specific automatic equipment, the technical solutions to be found have to provide a cheap way to identify each element of a shoe model. Each model has different shapes, sizes colours, etc... This computer controlled equipment will enable SME's to respond to small size orders to produce many different models as requested. The customers orders will drive the production. High productivity gain up are expected and workers can be reaffected to less tedious and repetitive work. The volonty of modernisation will drive them to achieve the following objectives: * decrease of manufacturing cycle * improvement of manufacturing reproductibility * permanent control of manufacturing process * optimal use of manufacturing capacity * storage of know-how - * high flexibility of the production cycle Some important figures which sum up the potential gains for the SMEs. projy number of lasts per model 100 600 cycle time for the return of 2 days number of persons on the production line 4 to 6 20 exit The proposed automated project will include launching, assembly, finish and packaging which are operations where important gains of productivity will be reached.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Responding to Development Challenges in China Through Research and Assessment of Suitable Industrial Protocol in the Processing of Fruits and Vegetables' under Sixth Framework.

assistant: **Concept**

The People's Republic of China has made significant efforts to develop economic agreements with the European Community. This has also long been a priority for the European Community. The proposed project directly responds to this agenda. The general objective of this project is to strengthen the European Community's partnership with China. This will be supported through collaborative efforts to address China's developmental challenges pertaining to processing chains for fruits and vegetables. The first phase will focus on the research and analysis of current Chinese policies for agro-food production with respect to fruits and vegetables. In the second phase, the research and analysis of standards practiced in China will be conducted with specific support provided to 15 Chinese processing companies. The third phase will consist of extrapolating the project team's findings to the sector and developing recommendations applicable to the sector as a whole. The fourth and final phase will involve the dissemination and the promotion of the findings both in Europe and China with strong focus on developing future research collaborative activities.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most common childhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Central Authority and Local Strenght in Early Middle Ages: Comparing social complexity in Northern Iberia and Central Italy (8th – 10th centuries)' (CALOSEMA), addressing dissemination and exploitation.

assistant: **Impact**

Intending the Early Middle Ages as one of the most astonishing political and social laboratories in Europe’s history, the main goal of “CALOSEMA” project is the study of social complexity between the 8th and 10th centuries, comparing societies and political landscapes from two European macro-regions: Northern Iberia and Central Italy, in order to (a) to investigate social, economic and political complexities on a continental scale, with the main intention of interpreting “landscapes of social and political inequality” going beyond the contraposition between History and Archaeology; (b) to create a social theory which would allow the insertion of medieval examples in the existing historiographical debates and, finally, (c) to deepen the concepts social and political inequality in the historical evolution of societies and powers which must be always considered as processes in progress, (d) to deconstruct historiographical rhetorics about the birth of different nations and states in Europe (and the origin of Europe itself) in the Early Middle Ages.Therefore, there is a specific rational choice behind the selection of these specific examples. In the past few decades, led by new critical approaches to analyse existing written sources and by the discovery of new material data from a number of newly excavated sites, renewed interest has been devoted to the study of Castile, Álava (from Iberia) and Tuscany (from Italy) which has shed new light on the social and political complexities of those territories. The results of those case studies, which would involve a critical dialogue between the historical and archaeological findings, will be discussed with reference to previous work carried out by the candidate, Dr Igor Santos Salazar, PhD in Medieval History and specialist in soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure and Function-based Design of Vaccine Antigens and Antiviral Immunotherapies' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Vaccines are critical in preventing viral diseases, and recent advances in vaccine development and delivery platforms have enhanced their reach and efficacy. Viral glycoproteins that mediate host cell entry are the primary target of the humoral immune response and thus the main antigenic component of vaccines. However, for many viruses, we lack fundamental biological insights that would easily allow transforming their glycoproteins into highly effective vaccine antigens.In this proposal, I introduce a completely novel approach to thoroughly extract structural and functional insights of viral glycoproteins for rational design of superior antigens. By conducting nanobody repertoire screens, I will bypass common constraints encountered in antibody screening, such as immunodominance bias and redundancy. Contrasting with conventional techniques that narrowly target a limited selection of epitopes, my approach promises an exhaustive mapping of glycoprotein surfaces and epitopes. This paradigm shift enables antigen rather than antibody or nanobody characterization. By determining high-resolution cryoEM structures of nanobodies bound to glycoproteins in transitional states, we will understand their structural dynamics.Equipped with these unparalleled insights, we will harness pioneering deep learning methods to computationally design glycoproteins with enhanced antigenic form and exposed neutralizing surfaces. I will showcase this method for viruses with high case fatality rates, including Hendra, Nipah, Lassa, Tick-borne encephalitis, and Borna disease viruses. VaxVision is set to offer a comprehensive framework for the antigen design of these and genetically or structurally related viruses.My work aims to capitalize on the unused potential for vaccine antigen improvement and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Two Stage Rapid Biological Surveillance and Alarm System for Airborne Pathogenic Threats'.

assistant: **Innovation**

The aim of this project is to develop a demonstrable, modular and “close-to-market” demonstrator of a stationary rapid reliable vehicle-portable Two Stage Rapid Biological Surveillance and Alarm System for Airborne Threats (TWOBIAS) with extremely low false alarm rates. TWOBIAS will provide reliable information to command control systems (CCS) and first responders within seconds, enhancing security related to biological threats at high profile public sites. (figure 1.) The TWOBIAS system includes both detection (BDU – biological detection unit) and identification (BIU – biological identification unit) schemes: i) StageONE: First alarm based on best-in-use optimized optical BDU (detect-to-warn) ii) ii) StageTWO: Second alarm based on highly automated microfluidic-based platform with a molecular BIU (detect-to-treat) The development of reliable biological surveillance and detector systems depends on significant extensive critical testing and evaluation (T&E) of the system, not only in controlled closed environments, but also at the real site of interest, prior to its operative use. Today, real-life testing is lacking. The approach of the project is unique in that the consortium will employ real-life test facilities to develop and prove a demonstrator of TWOBIAS for a successful approach to biological threats. Partner 6 (SCB) will provide a real-life test facility in central Europe that is regarded as a potential target for bioterrorism (i.e. Prague metro station). The project is distinctive because a detector and surveillance system for airborne biological threat agents will be developed according to the operational requirements by the end-user. TWOBIAS is not restricted for use against bioterrorist attacks, but is also suitable for detecting and identifying emerging natu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ultrastrong optomechanical coupling for quantum optomechanics experiments and novel radiation-pressure devices' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The coupling between light and mechanical motion through radiation pressure enables both fundamental experimental research into the quantum behavior of macroscopic objects as well as new technological applications such as light-actuated high-frequency resonators. Crucial to both is the realization of strong optomechanical coupling. We propose to develop novel optomechanical systems that exhibit ultrastrong interactions between light and motion to achieve cooling of a mechanical oscillator to the quantum ground state and to demonstrate new optomechanical functionality. Miniaturized silica toroidal resonators supported by 'spokes' serve as optomechanical resonators with small effective mass and ultra low loss, which are expected to enable ground state cooling. Moreover, we will use two-dimensional photonic crystal cavities in which phononic and photonic modes are highly co-localized to achieve ultrastrong coupling between a cavity mode and high-frequency mechanical oscillations. These systems can perform as all-optically tunable GHz oscillators. The strong coupling and low effective masses of these systems, as well as straightforward integration on a chip, make photonic crystal cavities promising candidates for a next generation of cryogenic quantum experiments. Finally, we will explore for the first time the possibilities of optomechanics in plasmonic systems, which concentrate electromagnetic fields in nanoscopic  volumes to achieve giant light-matter interactions.The applicant, Ewold Verhagen, performed his PhD research at the FOM Institute for Atomic and Molecular Physics in Amsterdam, The Netherlands. He published a total of 15 papers in the field of nanophotonics. His main achievements include the demonstration of adiabatic nanofocusing of light and the realization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SCIence Data Infrastructure for Preservation – Earth Science' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The aim of this initiative is to address priorities a) and c) of the call INFRA-2011-1.2.2: Data infrastructures for e-Science. It is about delivering long-term preservation services as part of the data infrastructure for e-Science.We aim to deliver generic infrastructure services for science data preservation that address the persistent storage, access and management required by the call and to build on the experience of the ESA Earth Observation Long Term Data Preservation (LTDP) programme to favour the set-up of a European Framework for the long term preservation of Earth Science (ES) data through the definition of common preservation policies, the harmonization of metadata and semantics and the deployment of the generic infrastructure services in the ES domain.The generic services will build on the already proven research prototype services from the CASPAR project. We will evaluate and tune these services in depth, using Earth Science as pathfinder, and broadly but less deeply across other disciplines linked to the Alliance for Permanent Access (APA) and ESFRI clusters. Earth Science presents an enormous challenge to the providers of data-infrastructure because it is inherently a very broad and scattered domain with completely different instruments operated by different entities, which at the moment apply different data preservation policies – or none at all. This work is important because it will allow our society to properly preserve the digitally encoded information on which we all depend, in particular Earth Science measurements which can never be repeated and yet on which a multitude of ecological, economic and political decisions must be based in the future. The generic services will allow all kinds of data to be usable by researchers from many different domai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Topoisomerase-induced DNA breaks: link with cancer and neurodegeneration' under Seventh Framework.

assistant: **Concept**

DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism. Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent implications in tumorigenesis. This peculiarity of topoisomerase catalysis also underlies the anticancer efficacy of topoisomerase poisons, which inhibit the re-ligation step of the reaction inducing the formation of DNA breaks that preferentially target highly proliferating and/or repair defective tumour cells. In addition to this link with cancer therapy, defects in the repair of topoisomerase-induced DNA damage have been linked to progressive neurodegenerative disease.Fully understanding the mechanisms and regulation governing the repair of topoisomerase-induced damage is therefore extremely important to gain new insights into two processes that are a main concern to human health: (a) cancer, both its onset and its therapy, and (b) neurodegenerative disease.We will combine the use of animal models with biochemistry and molecular and cellular biology techniques to explore different aspects of the repair of topoisomerase-induced breaks. We will mainly focus on our recently identified tyrosyl DNA phosphodiesterase 2 (TDP2), studying its mechanism of action and regulation with special attention to the possible implications in cancer and neurodegeneration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Precision Gravity: From the LHC to LISA' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The nascent field of gravitational wave (GW) science will be an interdisciplinary subject, enriching different branches of physics, yet the associated computational challenges are enormous. Faithful theoretical templates are a compulsory ingredient for successful data analysis and reliable physical interpretation of the signals. This is critical, for instance, to study the equation of state of neutron stars, the nature of black holes, and binary formation channels. However, while current templates for compact binary sources may be sufficient for detection and crude parameter estimation, they are too coarse for precision physics with GW data. We then find ourselves in a situation in which, for key processes within empirical reach, theoretical uncertainties may dominate. To move forward, profiting the most from GW observations, more accurate waveforms will be needed.I have played a pioneering role in the development and implementation of a new formalism, known as the ‘effective field theory approach’, which has been instrumental for the construction of the state-of-the-art GW template bank. The goal of my proposal is thus to redefine the frontiers of analytic understanding in gravity through the effective field theory framework. Even more ambitiously, to go beyond the current computational paradigm with powerful tools which have been crucial for `new-physics' searches at the Large Hadron Collider. The impact of the high-accuracy calculations I propose to undertake will be immense: from probes of dynamical spacetime and strongly interacting matter, to the potential to discover exotic compact objects and ultra-light particles in nature. Furthermore, GW observations scan gravity in a regime which is otherwise unexplored. Consequently, the coming decade will tell whether Eins