RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of NFAT5 during the transcriptional response to cellular growth' (TRECEG).

assistant: **Concept**

This proposal addresses the role of the transcription factor NFAT5 in cell growth and proliferation in normal and transformed cells. NFAT5, the latest addition to the Rel (NFATc/ NF-kB) family of transcription factors, is activated by hypertonicity, but also responds to antigen receptor stimulation in lymphocytes and integrin-induced signals in carcinoma cells, responses that involve mechanisms which at present are poorly understood. In the mouse, NFAT5 protein is expressed in most organs during embryonic development but its levels decrease dramatically in most adult tissues, except at sites with high cellular turnover, such as thymus and testis, where NFAT5 is highly expressed. In vitro, expression of NFAT5 correlates with cellular proliferation in both normal and transformed cells.NFAT5 null mice have reduced embryonic and perinatal survival, and those surviving into adulthood have a striking growth phenotype with an overall reduction of body and organ size. In addition, their life-span is severely compromised, owing in part to progressive renalatrophy as mice age, caused by defective regeneration of the kidney medulla associated to the lack of expression of NFATS-dependent osmoprotective genes. The kidney phenotype of NFAT5-null mice confirms its role in osmoprotective responses in vivo. However, it does not explain the embryonic mortality and growth defects, indicating that NFAT5 has additional, cell growth-related functions.We propose to investigate NFAT5 function by analysing cell growth-related parameters (proliferation, cell cycle, apoptosis) in normal wild type and NFAT5-null cells. Since tumor progression requires sustained proliferation, we will address whether NFAT5 might be involved in tumor formation by determining the ability of specific oncogenes to tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adaptive Scheduling and Deployments of Data Intensive Workloads on Energy Efficient Edge to Cloud Continuum' to be submitted under Horizon Europe.

assistant: **Abstract**

ENACT develops cutting-edge techniques and technology solutions to realise a Cognitive Computing Continuum (CCC) that can address the needs for optimal (edge and Cloud) resource management and dynamic scaling, elasticity, and portability of hyper-distributed data-intensive applications. At infrastructure level, the project brings visibility to distributed edge and Cloud resources by developing Dynamic Graph Models capable of capturing and visualising the real-time and historic status information, connectivity types, dependencies, energy consumption etc. from diverse edge and Cloud resources. The graph models are used by AI (Graph Neural Networks - GNN) models and Deep Reinforcement Learning (DRL) agents to suggest the optimal deployment configurations for hyper distributed applications considering their specific needs. The AI (GNN and DRL) models are packaged as an intelligent decision-making engine that can replace the scheduling component of open-source solutions such as KubeEdge. This will enable real-time and predictive management of distributed infrastructure and applications. To take full advantage of the potential (compute, storage, energy efficiency etc) opportunities in the CCC, ENACT will develop an innovative Application Programming Model (APM). The APM will support the development of distributed platform agnostic applications, capable of self-determining their optimal deployment and optimal execution configurations while taking advantage of diverse resources in the CCC. An SDK to develop APM-based distributed applications will be developed. Moreover, services for automatic (zero-touch provisioning-based) resource configuration and (telemetry) data collections are developed to help design and update dynamic graph models. ENACT CCC solutions will be validated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conception and realization of lasers system stabilizations for large scale interferometric gravitational wave detectors' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The goal of the VIRGO project is the detection of gravitational radiation with a large base interferometric detector. In order to reach the expected sensitivity, the laser of the interferometer has to be stabilized in frequency and in amplitude. In particular the level of frequency stabilization need very stable references, and is obtained with a two stage system: in the first we compare the laser frequency with the resonance frequency of an ultrastable Fabry-Perot cavity, and in the final stage we compare the laser frequency with the resonance frequency of the long Fabry-Perot arms. My present application concerns the still open subject of the study and realization of the final step of stabilization, in particular: - The understanding of interactions of this step with the previous stabilizations system of the laser and the interactions with the interferometer locking". - The realization of an experiment to test this stabilization system, in which the interferometer is simulated by a small Fabry-Perot cavity or a small interferometer. - The test of the whole laser system in Orsay, and then on VIRGO site (Italy) in 1998. This R&D has interactions with the British-Germany interferometric gravitational detector GEO, and with the french company BMI, which participate at the laser construction. Training content (objective, benefit and expected impact) Links with industry / industrial relevance (22) "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An ARTery of EMPIRE. Conquest, Commerce, Crisis, Culture and the Panamanian Junction (1513-1671)' (1513-1671) targeting Horizon 2020.

assistant: **Abstract**

European incursions onto the narrow isthmian pass that divided and connected the Atlantic and Pacific oceans made it a strategic node of the Spanish Empire and a crucial site for early modern globalization.  On the front lines of the convergence of four continents, Old Panama offers an unusual opportunity for examining the diverse, often asymmetrical impacts of cultural and commercial contacts. The role of Italian, Portuguese, British, Dutch, and French interests in the area, as well as an influx of African slaves and Asian merchandise, have left a unique material legacy that requires an integrated, interdisciplinary approach to its varied sources. Bones, teeth and artifacts on this artery of Empire offer the possibility of new insights into the cultural and biological impact of early globalization.  They also invite an interdisciplinary approach to different groups’ tactics for survival, including possible dietary changes, and the pursuit of profit. Such strategies may have led the diverse peoples inhabiting this junction, from indigenous allies to African and Asian bandits to European corsairs, to develop and to favor local production and Pacific trade networks at the expense of commerce with the metropolis.This project applies historical, archaeological and archaeometric methodologies to evidence of encounters between peoples and goods from Europe, America, Africa and Asia that took place on the Isthmus of Panama during the sixteenth and seventeenth centuries.  Forging an interdisciplinary approach to early globalization, it challenges both Euro-centric and Hispano-phobic interpretations of the impact of the conquest of America, traditionally seen as a demographic catastrophe that reached its nadir in the so-called seventeenth-century crisis.  Rather than applying qu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Not Knowing in Deep Representation Learning' in the context of a Horizon Europe call.

assistant: **Objectives**

Machine learning and artificial intelligence techniques are progressing at a tremendous pace and impressive results appear across scientific fields. However, as machine learning models grow in capacity, they become increasingly ‘black box’, and it becomes harder for humans to reason about the patterns discovered by the machine. A root cause of this difficulty is that most machine learning models can express the same pattern in infinitely many, equally good, ways within their internal representations of the world. This is known as an identifiability problem.Today we lack a general solution to identifiability problems, and either give up on understanding the patterns discovered by the machine or reduce model complexity to lessen the problem. The latter also reduces the fidelity and applicability of the model. NoKnow rephrase the question of identifiability to be concerned with tasks solved by the representation rather than the representation itself. Using tools from differential geometry and Bayesian inference, we develop the theoretical tools to ensure that tasks solved in the representation have an identifiable outcome even if the representations themselves are not identifiable.To turn theory into practice, we develop state-of-the-art algorithms for assessing the uncertainty of learned representations in order to indirectly estimate the topology of the representation manifold. We further develop novel, high-fidelity predictive models that have identifiable outcomes when trained on learned representations.NoKnow provides the fundamental tools needed to engage with learned representations to guarantee identifiable outcomes. This, in turn, increase trust in findings as they are not dependent on arbitrariness in learned representations. As society increasingly automates dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A unique multi-layer deposition process for optimised production of the next generation of Li-ion batteries.' (Coldab) targeting Horizon 2020.

assistant: **Abstract**

Despite being an ideal solution to the global challenge of tackling the effects of transport emissions, Electric Vehicles (EVs)have not yet achieved significant mass market penetration. This is mostly due to the fact that the development in the EVbattery industry has been rather incremental, without revolutionary breakthrough since 1991. LiBs represent the goldstandard in the industry; however, they suffer from many issues which are detrimental to the widespread adoption of EVs.These are mainly related to insufficient performance, in terms of size, energy density and safety, expensive and rigidproduction while existing deposition methods has low production rate thus affecting the overall supply of EVs in comparisonto high-growth demand (CAGR of 20%).Pulsedeon developed Coldab, a coating technology leveraging Ultra-Short Pulsed Laser Deposition (USPLD), that canoptimize production of LiB & its components on a large scale. Coldab’s unique USPLD process allows cost-effectivemanufacturing of a new class of safer, smart tailored, high-performance EV batteries. Pulsedeon favours thecompetitiveness of European battery manufacturers by offering a cutting-edge manufacturing process and promotes a cleanenvironment. To increase the EV’s affordability & improve their performance, Coldab brings battery manufacturing to a newlevel of scalability, at the same time preserving performance by increasing the battery’s energy density and safety.Overall objective of Pulsedeon is to introduce a paradigm shifting within EV battery manufacturing process to facilitate thewidespread adoption of EVs. During the innovation project, Pulsedeon intends to upgrade & validate Coldab system toautomate the production of LiBs & its components, conduct extensive validation tests of the system and produced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mating structure and sex ratio conflicts in polyembryonic parasitoids' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Mating structure, the number and identity of a female's mates, is a central parameter in sex ratio theory. Despite this importance, mating structures have received little attention: empirical work has focussed on testing the predictions of theory rather than the underlying assumptions. Parasitoid Hymenoptera have control of progeny sex ratios and have been important to the development and testing of sex ratio theory. Empirical assessment of parasitoid mating structures, and their relation to observed sex ratios, is lacking and urgently required. This is particularly the case in polyembryonic parasitoids (multiple offspring develop from a single egg) in which non-sibling mating causes parent-offspring and intersexual offspring-offspring conflicts over the sex ratio. I will relate mating structure to sex ratio conflicts in the polyembryonic parasitoid Copidosoma sosares. I will combine behavioural observations with newly developed molecular genetic techniques to obtain reliable estimates of mating structure. Empirical work will be carried out in both the laboratory and the field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Global Under-Resourced MEedia Translation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Machine translation (MT) is an increasingly important technology for supporting communication in a globalised world. MT technology has gradually increased over the last ten years, but recent advances in neural machine translation (NMT), have resulted in significant interest in industry and have lead to very rapid adoption of the new paradigm (eg. Google, Facebook, UN, World International Patent Office).  Although these models have shown significant advances in state-of-the-art performance they are data intensive and require parallel corpora of many millions of human translated sentences for training. Neural Machine translation is currently not able to deliver usable translations for the vast majority of language pairs in the world. This is especially problematic for our user partners, the BBC and DW who need access to fast and accurate translation for languages with very few resources. The aim of GoURMET is to significantly improve the robustness and applicability of neural machine translation for low-resource language pairs and domains. GoURMET has five objectives:- Development of a high-quality machine translation for under-resourced language pairs and domains;- Adaptable to new and emerging languages and domains;- Development of tools for analysts and journalists;- Sustainable, maintainable platform and services;- Dissemination and communication of project results to stakeholders and user group.The project will focus on two use cases:- Global content creation - managing content creation in several languages efficiently by providing machine translations for correction by humans;- Media monitoring for low resource language pairs - tools to address the challenge of international news monitoring problem.The outputs of the project will be field-tested at partners BBC and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polymer characterisation using electron capture dissociation and collision-induced dissociation multistage mass spectrometry' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Millions of tons of a great variety of polymers are synthesised every year to serve a multi-billion Euro market. Responsible entrepreneurship of manufacturers of polymers and surface chemicals focuses the research efforts on environmental risk, biodegradability, sustainability, durability and optimisation of properties to fit the customers' needs. Mass spectrometry plays an important role in the characterisation of the polymers designed. Yet, a knowledge base and experience must be generated to facilitate t he choice of experimental conditions for fast and accurate structural characterisation by multistage mass spectrometry.The POLY-MS project comprises six challenging Marie Curie Early Stage Research Trainings to generate knowledge of mechanisms that play a role in multistage mass spectrometry of different polymer classes. Collision-induced dissociation and electron capture dissociation of polymers will be investigated. Modelling of reaction kinetics and quantum chemical calculations will be carried out to provide a theoretical perspective and interpret the observations. Another task is to devise a methodology for implementation of automated atmospheric pressure ionisation multistage mass spectrometry as high-throughput structure analysis of products from high-throughput experimentation. The project consortium is a strong combination of three academic partners and one industrial partner.The project will allow the six research fellows to develop research skills in mass spectrometry, ion physics and separation techniques in a dynamic and stimulating environment. It will allow the research fellows to develop a variety of complementary skills. Fast and accurate characterisation of research oligomers and polymers accelerates, by improving the understanding of their structur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Proteomic analysis of signaling induced by receptor tyrosine kinase endocytosis'.

assistant: **Objectives**

Stimulated Receptor Tyrosine Kinases (RTKs) regulate several key cellular processes, such as cell proliferation, differentiation, migration and transformation, by activating specific intracellular signaling pathways. Endocytosis, the process by which cells internalize and sort RTKs for either degradation or recycling, is a potent regulator of signal transduction specificity and cellular outcomes. Several RTKs have been shown to escape from the canonical degradative route under certain conditions, resulting in signaling amplification - which often results in tumorigenesis. In particular, EGFR and FGFRs follow opposite endocytic routes upon stimulation by different ligands. This application focuses on EGFR and FGFRs as model systems to define signaling cascades that are specifically regulated by the different endocytic pathways. We will integrate an unbiased data-driven approach consisting of quantitative proteomics, based on high-resolution mass-spectrometry in combination with proteome-wide metabolic incorporation of stable isotopes, followed by proper functional assays to validate the results. This system biology approach will shed light on some previously uncharacterized aspects of RTK signaling regulation at the whole-cell level, gaining insights into the molecular mechanisms underlying endocytosis-driven cellular responses. Since aberrant RTK signaling is a hallmark of various diseases, such as many cancers, the implications of our studies extend beyond basic research, offering the opportunity to identify novel therapeutic targets, e.g. for the development of anti-cancer drugs. These objectives are part of European research’s efforts to elucidate physiological processes, search for pathogenic events and novel targets and contribute to the technological progress of p