RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular, cellular and genetic interactions in vertebrate eye development (EYE DEVELOPMENT)' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

A molecular explanation of how the vertebrate eye is built is the goal of this proposal. This is broken into three stages, the formation of the eye anlagen, the subdivision of the optic vesicle into the retina, pigment epithelium, and optics talk, and the generation of various neuronal cell types in the retina. The experiments here take advantage of modern molecular genetic analysis in four powerful vertebrate species to elucidate the roles the key genes involved in these processes and to identify new genes. Much of the work is focused on understanding the genetic and cellular interactions, the interplay of signalling molecules and transcription factors, extrinsic and intrinsic components of the genetic network of eye development. The recent discovery of retinal stem cells in vertebrates stimulates the last part of this proposal, a detailed characterisation of these cells using the knowledge gained from the investigation into eye development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biochemical and Structural characterization of signal transduction by OTU family of Deubiquitinases' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Ubiquitination is a reversible post-translational modification (PTM) regulating diverse cellular functions including cell cycle, apoptosis, gene expression, inflammation and DNA repair. Ubiquitination results in the tagging of proteins with either monoubiquitin or polyubiquitin chains of different linkages that are structurally distinct. Given that protein ubiquitination is involved in so many cellular processes, it needs to be under very tight regulation. Protein ubiquitination is reversed by deubiquitinases (DUBs), which are specialized proteases that cleave the isopeptide linkage between ubiquitin molecules in chains or between ubiquitin and protein substrates. The objective of this study is to understand how substrate specificity is determined and in particular, how function of the A20-family of ovarian tumour (OTU) DUBs is regulated. I will crystallize the catalytic domains of OTU family DUBs involved in cell signalling, to understand their ubiquitin chain linkage specificity. I intend to establish how the interacting scaffolding proteins of A20-like DUBs, such as ABIN and TAX1BP1, mediate substrate targeting and specificity, and allosterically regulate enzyme activity. I shall express full-length protein complexes of A20 and Cezanne together with their interacting proteins using multi-gene baculovirus and mammalian systems. I will use X-ray crystallography and electron microscopy to understand the structure and conformational changes regulating DUB complex activation. The structural insights obtained will be used to understand oncogenic DUB mutants, and establish how DUB dysregulation leads to tumorigenesis. Lastly, I will analyze how reversible oxidation regulates DUBs during signalling. The proposed structural and biochemical characterisation of the multi-subuni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'MVISION'.

assistant: **Objectives**

MVision programme intends on building a particularly favourable environment to train and reinforce career development of best researchers in biomedical imaging. Foundation Madri+d (a public foundation dependent on the Madrid Regional Government) will count with the support of the Massachusetts Institute of Technology to catalyze fellowships biomedical imaging education and research.The objectives of the project are: (i) leveraging Madrid’s investment in biomedical imaging infrastructure and clinical network and MIT’s experience in integrating biomedical imaging research and education (ii) attracting and nurturing top talents by providing broad-ranging education and research experiences in cutting edge biomedical areas (iii) promoting work that is translational and posed for impact in medicine and healthcare (iv) creating a network of professionals in the academic, medical, industry and government sectors.MVision in its 60 months length will offer 30 fellowships to experienced researchers under adequate researcher labour conditions to develop research projects in the frame of hosting institutions (universities, research centres, pharmacies, chemistries or hospitals).MVision offers the opportunity to receive top level customized training in Madrid and Boston, helping fellows to design their research projects during the first year and providing them two to three years to implement their individual driven research projects in a wide range of hosting institutions. Fellows will benefit from the knowledge, expertise, and existing networks of hosts and MIT, and will be encouraged to foster long term relationships.Researchers will be selected by an international panel through a transparent evaluation process following the European Code of Conduct for the recruitment of researche
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of replacement method for all kind of 16g dynamically tested aircraft cushions.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Airline operators are faced with increased need to replace passengers seat cushions, certified for security standards at sustainable retrofit costs. Since October 2009, the Federal Aviation Administration (FAA) regulation 121-135 has imposed more strict standards for aircraft seats, which must sustain a load of 16g in forward direction and 14g in down direction. As a consequence airlines need to gradually replace current ""9g seats"" (approx. 65% of current aircraft seats) with new ones compliant with the 16g standard. At present the 16g certification requires testing of the entire seat, which may cost up to 1,3 K€/pax. while a new certified cushion may cost 200-250 €. The aircraft cushions and seats market is almost totally occupied by a few manufacturers who keep prices high, especially when the original cushion model is phased-out and either the entire seat must be replaced, or costly custom-made cushions produced. Consequently many airlines avoid replacement or adopt non-standard cushions, despite risks for passengers' safety. Testori Aero Supply has achieved a EASA approval for a certification method for 16g monolithic cushions, and has already produced such replacement cushions for a client on a Boeing B777. At present Testori is the only independent company holding this qualification. This project intends to exploit this method to the certification of 16g multilayer cushions, and to produce and sell them at a competitive price of 200-250€.The feasibility study will assess the market positioning, the industrialization and production costs, the market demand and the market potential for the company, taking into consideration the customers (airline operators) and the aircraft fleets (current  and new) in the areas where Testori already successfully operates. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Photonics from research to market: Empowering Europe’s strategic autonomy, supporting the green deal and securing resilience – Photonics21'.

assistant: **Innovation**

Phorwards21 will create and implement a comprehensive industrial strategy for photonics in Europe. The action will be implemented by Photonics21 (the EU Commission's partner in the Horizon Europe Photonics Partnership) with its more than 3000 members from companies and research institutions as well as national photonics technology platforms and regional clusters. In addition to already initiated collaborations with end-user and other deep-tech partnerships, contacts with national ministries (Photonics21 Mirror Group) and financial actors such as the European Investment Bank (EIB), the European Investment Council (EIC) and (corporate) venture capital companies will be strengthened to implement the European photonics strategy and thus establish European strategic autonomy in this critical technology. Specific end-user community-based roadmaps will be developed, focusing not only on research priorities but also on industrial implementation, including pilot lines and the creation of appropriate framework conditions.


**Keywords:** Strategic Autonomy, Key Technology, Strategic Research and Innovation Agenda, Supply Chains
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigation on damage tolerance behaviour of aluminium allays (IDA)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Modern transport aircraft are designed for high efficiency and long service lives, resulting in heavy loaded structures. This application requires damage tolerant materials with low crack propagation rates. Recently improved alloys have been developed, enabling also new joining technologies like laser beam welding. These materials reveal a lack of understanding of the microstructure-crack growth relationship, existing for the well-known alloy 2024. This missing knowledge will be attained in this project by comprehensive material characterization to identify the complex fatigue and fracture relevant microstructure-crack growth relationship. Thorough fatigue crack propagation testing and complementary examination on crack surface morphology, plastic zone and crack closure effects will be performed. Based on the attained knowledge prediction models will be established and verified. Recommendations for optimisation of microstructures will be derived. This specific information will allow optimised application of the recently developed damage tolerant materials and laser beam welding technology, consequently improving Aircraft Efficiency
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Fluid Dynamics and Quantum Gravity' (FluiDGravity).

assistant: **Concept**

Using and combining the experiences and tools from quantum field theory, gravity and fluid dynamics, the goal of this proposal is to address the challenging task of mapping the Navier-Stokes turbulence problem to a general relativity problem. For this we will study fluctuations of certain d-dimensional geometries at a cutoff surface beyond the linear order, and study the map to the nonlinear fluid dynamics. We also aim to contribute further to the development of efficient methods for identifying the regular and stable black hole solutions. A preliminary screening already suggests the existence of a new well-behaved black hole solution, namely a supersymmetric helical black ring, which we want to engineer employing powerful solution generating techniques. Progress along these lines will certainly bring new insights to some of the most exciting and long standing problems in fluid dynamics and gravity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Human chemokines and their receptors: genomic organization of the gene families, functional characterization of their members and relevance to human diseases' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Chemokines are small-secreted proteins that recruit white blood cells to the sites of inflammation. They play a fundamental role in the host defence against infection by viruses, bacteria and parasites. The protective effects of chemokines can however turn harmful to healthy tissues when their expression is inadequate. Chemokines contribute therefore to the damage in a wide range of acute and chronic inflammatory diseases. Chemokines have also been involved in number of other physiological and pathological processes. MCP-1 contributes to the development of artery-blocking plaques in atherosclerosis. Several chemokinare involved in cancer, either as growth factor GRO alpha), or as agents promotineo angiogenesis (IL-8). Others, such as PF-4, have potent angiostatic properties, and are considered as potential anticancer agents. MIP-1alpha, amon others, regulates differentiation, mobilization and proliferation of bone arrow stem cells. Recently, MIP-1alpha, MIP-1beta and RANTES have been identified as the major HIV-suppressive factors produced by CD8+ lymphocytes, and two chemokine receptors (an orphan receptor termed fusin, and CC-CKR5) were shown constitute the accessory factors (in addition to CD4) required for HIV-1 fusion with its host cells. This array of biological functions makes of chemokines and their Gprotein-couple receptors important targets for the pharmaceutical industry, in various therapeutic areas. Importantly, the range of actions of individual chemokines, and the cell distribution of their receptors, is relatively specific, as compared to other cytokine and cytokine receptor families.Therapeutic agents acting on restricted cell populations can therefore be considered. Nevertheless, much has still to be done to apprehend chemokine signaling as a whole. Ov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Ocean's Oxygen Isotopes Deciphered: Combining Observations, Experiments and Models' (OOID).

assistant: **Innovation**

The isotopic composition of O in seawater is a fundamental property of Earth's oceans, key to paleoclimate reconstructions and to our understanding of the origin of water on Earth, the water-rock reactions that govern seawater chemistry, and the conditions under which life emerged. Despite more than five decades of research, the geologic history of seawater 18O/16O remains a topic of intense debate. Without exception, well-preserved 18O/16O records from marine precipitates reflect both the minerals' formation temperature, and the isotopic composition of seawater. This duality has prevented unique interpretation of a long-term secular trend, in which 18O/16O in sedimentary rocks (e.g., carbonates, cherts) has increased by ~15 ‰ since the Archean. Here I outline an inter-disciplinary research program to address this fundamental problem, which integrates new geochemical observations, laboratory experiments, and numerical models.We will generate geologic records of 18O/16O in two previously untapped repositories: iron oxides and iron-bearing authigenic clays. Several characteristics of both, and preliminary results, suggest that these repositories hold the potential to settle the long-standing debate about seawater 18O/16O. We will determine the temperature dependence of mineral-water O isotope fractionation in laboratory experiments and observations of natural systems. We will experimentally test the resistance of these minerals to O isotope exchange under geologically-relevant conditions, with the aim of evaluating the potential for late-stage isotopic resetting. Finally, we will develop models of the marine O isotope cycle, which account for the processes that govern seawater 18O/16O over long timescales, and which will be used to provide a quantitative understanding of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Sulfur isotope fractionation during sulfate reduction by archaea and in hydrothermal sediments'.

assistant: **Innovation**

Research objectives and content The chemistry of the Earth surface has changed through time from a chemically reducing stage to the oxidized stage we know to day. Important aspects of the evolution of the chemical conditions at the Earth's surface can be read from stable isotopic compositions of sulfide deposited in ancient sediments. During dissimilatory sulfate reduction by Eubacteria sulfide is produced depleted in 34S. Deposits of sedimentary sulfide depleted in 34S are therefore an indication of bacterial sulfate reduction, and further indicate a sulfate-rich ocean. To adequately interpret the ancient record, isotope fractionation by the relevant bacterial species must be understood. It has been proposed that life on Earth originated at high temperature in hydrothermal vent environments, and that the early oceans were warmer than today. The thermophilic Archaea, Archaeoglobus sp., represents the oldest lineage of sulfate reducing bacteria, and is the closest relative known to the earliest sulfate reducers Isotope fractionation during sulfate redution by Archaeoglobus has never been measured and will be a focus of this study. Furthermore isotopic fractionation during sulfate reduction by natural populations from hydrothermal sediments will be measured. Together, these measurements will constrain the range of expected fractionations from ancient ocean sediments and hydrothermal areas, considerably constraining our interpretation of the isotope record of sedimentary sulfides. Training content (objective, benefit and expected impact) Training: 1. Gain a broader understanding of the chemical and biological evolution of the Earth's surface. 2. Advance my skills in the isolation and culturing of bacteria 3. Work in close contact with scientist connected to the Earth Syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Uncovering the regulatory landscape of Arabidopsis thaliana responses to cold temperatures' (COOLCASE) targeting Horizon Europe.

assistant: **Abstract**

Plants, as sessile organisms, must constantly adapt to variable environmental conditions, among which temperature is of paramount importance in the context of climate change. Indeed, in future years, despite an expected rise in temperatures due to global warming, we can also expect an increase in the frequency of severe cold periods for which plants are not prepared. Therefore, understanding the molecular processes that allow plants to react and adapt to cold is essential for developing cold-resistant plants, which is ultimately indispensable for global food security. In recent decades many studies have embarked in addressing this issue. However, the global regulatory landscape underlying cold acclimation and adaption of plants to noisy and fluctuating natural cold conditions remain poorly investigated. Low temperatures are known to have a direct effect on chromatin accessibility which is directly linked to gene expression. Therefore, the aim of this project is to investigate the dynamics of the coding and non-coding Arabidopsis thaliana transcriptome, as well as changes in chromatin accessible sites, in response to regimes of decreasing temperatures. To this end, a comparative analysis of deep-coverage RNA-seq (transcriptome) and ATAC-seq (chromatin accessibility) will be performed on A. thaliana plants grown over weeks of fluctuating temperatures, mimicking natural cold conditions of autumn and early winter. The proposed experimental design will reveal novel coding genes, long non-coding RNAs (lncRNAs) and potential distal regulatory elements involved in Arabidopsis responses to cold. Thus, by combining interdisciplinary and mutually reinforcing approaches including (epi)genomics, (epi)genetics, transcriptomics and bioinformatics, the proposed project will significant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EUROPEAN METEOROLOGICAL EDUCATION AND TRAINING', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

EuroMET addresses the education and training needs of professional meteorologists and students in university education. The project is laying on novel distance courses for professionals and students in meteorology, and involves meteorological services and universities in 13 countries, as well as the European meteorological satellite organisation, EUMETSAT. The demonstration phase will draw on existing course content delivered via WWW and adaptable to local needs. Courses will exploit a variety of media and exceptionally powerful simulation of real-life weather phenomena. Initial validation will be at 40 sites in all participating countries.