RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Distributed adaptive security by programmable firewall'.

assistant: **Concept**

The vision of the project is to develop a novel and comprehensive security solution for secure broadband services, by combining the following: flexible implementation techniques for high-speed packet processing, algorithms for intrusion detection, and policy-based techniques for automated configuration and decision handling.The project aims for the general goal of development and deployment of innovative network components that enable service providers to offer to their customers secure broadband services in an effective and cost-efficient way.In order to achieve this overall goal, the project pursues the following individual objectives:- Design and implement an innovative architecture for provider-controlled distributed high-speed edge devices, aimed to become a new generation of distributed high-speed broadband firewalls with policy-based control, that are suitable to provide a comprehensive security solution meeting the needs of customers and service providers.- Develop and deploy enhanced techniques capable of detecting a wide range of security violations, in particular detecting DDOS (Distributed Denial of Service) attacks, but also suitable for detecting and identifying other types of malfunctioning. Achieve enhanced detection capabilities by designing flexible and effective solutions for distributed monitoring of application traffic.- Establish techniques for intelligent response to security violations, in particular providing an effective protection against DDOS attacks.¿Ensure fair, coherent, and efficient enforcement of security policies by management and control of the distributed firewall components.- Define use-cases for the new technology, deploy them in meaningful testbeds, and disseminate know-how and training of target people.The architecture ensures hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Wildland-urban area fire risk management' (WARM).

assistant: **Concept**

W.A.R.M. (Wild land-urban Area Fire Risk Management) project objectives, innovation and a detailed work plan are presented in this proposal. Wild land-Urban Interface (W-UI) Forest Fires are a major problem in several countries of Europe. A scientific approach is proposed here to complete a series of studies, experimentations and developments that will end up in a methodology and a computer-based Decision Support System. W.A.R.M. tool will assist wild land and urban planners to identify and solve forest fire risks to minimise losses and costs. Six case study areas have been selected in six different EU countries, where W-UI forest fires are a major concern of authorities and homeowners. Forest Services are willing to contribute with their experience to the development of the project. Public participation is a key activity in the project; an Internet project site will be set-up for that purpose.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting Root Hydraulic Architecture to improve Crops under Drought' (HyArchi), addressing dissemination and exploitation.

assistant: **Impact**

Water is the most limiting environmental factor for agricultural production worldwide and climate change exacerbates this threat. The HyArchi project will address this issue from a plant biology perspective and proposes new strategies to improve crop tolerance to drought. The main objective is to optimize water uptake and transport in cereals affected by drought. HyArchi will target maize, a major crop and a foundational model in plant genetics and water relations that is grown in irrigation or rain-fed conditions. HyArchi will consider three root traits: root system architecture, generated through continuous growth and branching; water transport; and environmental signalling. The first two traits yield the root hydraulic architecture. HyArchi will investigate how this architecture evolves in time and space by integrating local and systemic signals that communicate water availability. HyArchi proposes two innovative molecular discovery approaches recently validated by my group in model plants. Genome-wide association studies will be used to uncover novel genes, with signalling functions acting on root hydraulics. Transcriptomic analyses of an experimental split-root system will be used to identify molecules (e.g. hormones, miRNAs) involved in systemic signalling and governing root growth and hydraulics. These studies will be supported by key methodological developments. A semi-automated set of pressure chambers will be constructed to measure root hydraulics in multiple genotypes under highly controlled local root environments. Improved root image analyses will be coupled to mathematical modelling to represent local and systemic effects of water on root hydraulic architecture. Ultimately, HyArchi will deliver enhanced knowledge on root water transport and its control by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of Spin-orbit Coupling on Superconducting Pairing Interactions' under Horizon Europe.

assistant: **Concept**

Superconductors with spin-orbit coupling exhibit many fascinating properties, including abnormally high upper critical fields and possible topological excitations. These effects are recognized as originating from the impact of spin-orbit coupling on the Cooper pair wave function. In contrast, how spin-orbit coupling affects the superconducting pairing interactions – the glue that binds electrons together in Cooper pairs – remains an open question. This is particularly relevant in unconventional superconductors as the interplay between spin-orbit coupling and electronically mediated superconducting pairing interactions may give rise to novel feedback effects that boost the efficacy of the pairing interactions.In this project, I will adopt a dual-pronged approach to study the interplay between spin-orbit coupling and interactions: (1) Develop a generalized Eliashberg theory to account for feedback effects in spin-orbit coupled systems and (2) implement fermionic renormalization group methods and determinant Quantum Monte Carlo simulations to map out the interplay between electronic correlations and spin-orbit coupling.The main results of SuperSOC will be:- Establishing how spin-orbit coupling may fundamentally reshape the pairing interactions and modify the associated superconducting instabilities of unconventional superconductors.- Developing a framework for studying these feedback effects in material-specific models and employing this to understand the phase diagrams of unconventional spin-orbit coupled superconductors.- Demonstrating how the interplay between electronic correlations and spin-orbit coupling leads to anisotropic interactions that alter the shape of the electronic phase diagram and may enhance pairing.These achievements pave the way for identifying the na
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Host-environment interactions in the protection from asthma and allergies' (HERA) targeting Seventh Framework.

assistant: **Abstract**

Asthma and allergies are chronic conditions affecting billions of Europeans. These complex diseases are determined by interplay of genetic and environmental factors. Treatments can control symptoms, but cannot cure or prevent the diseases. I, and my team, have shown that children are strongly protected from asthma and allergies when growing up in a farming environment rich in microbial exposures: the prevalence of asthma and hay fever is reduced over 5 fold. We have shown that environmental exposure to microbial compounds is inversely related to asthma and allergies. We have isolated microbes from animal sheds which protect mice from allergic airway inflammation. My team is now at a critical point to move this work forward to the next step, which is to systematically identify the microbes and their immuno-stimulatory compounds that protect from asthma and allergies. We have key resources in hand. In previous population based studies large numbers of environmental samples from farm and non farm children with and without asthma and allergies have been stored in biobanks. Genome wide genotyping data have also been gathered. The HERA project aims at applying the latest innovative high throughput sequencing techniques to comprehensively characterize the microbial ecology of these environmental samples. New methods for assessing microbial immuno-stimulatory substances will be used. These innovations will allow the HERA team to identify distinct asthma and allergy protective microbial exposures taking each individual s genetic susceptibility into account. Once protective microbial exposures have been identified, the responsible substances can be isolated. These substances can be developed into novel and effective prevention strategies to combat the asthma and allergy epidemic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'RESILIENT SUPPLY CHAINS FOR EUROPE' (ResC4EU), addressing dissemination and exploitation.

assistant: **Impact**

The ResC4EU CSA is organized around 4 key objectives: (1) defining risk, disruption and alerts models for the supply chains of 14 “at risk” industrial ecosystems; (2) developing a holistic European value network for strengthening supply chains fostered by industrial clusters and strategic alliances; (3) accelerating the adoption of advanced methods and technologies for sustainability and resilience, through the use of a dedicated digital B2B platform, thereby benefitting from platform based growth models through network effects; and (4) demonstrating supply chain resilience of industrial ecosystems while also achieving climate neutrality and sustainability of economic processes. The consortium consists of 6 industrial clusters that have immediate access to over 1000 SMEs. Two research institutes cover logistics, supply chain risk modelling and product life-cycle analysis, respectively. Two SMEs, one orchestrating the outreach activities of the project and the other providing an open source, multisided, B2B supply chain platform derived from a Horizon 2020 project, complete the team.The workplan is designed to first activate the SMEs in the 6 clusters and then engage them in three ways: (a)  to foster knowledge transfer early on, between the more technology-aware SMEs and those interested in innovating their processes; (b) to develop an actionable model for supply chain analysis that can be supported by the platform and will lead to immediate supply chain risk mitigation and resilience; and (c) to create impact by fostering new pan-European as well as cross-regional collaboration using a mix of strategically planned physical meetings and large-scale virtual community-building activities, among them “ResC4EU Net-Zero Industry Academies”. The cluster organizations cover lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Toward a Situated Analysis of Musical Improvisation: A Case Study of South Indian Ritual Music' (AMIIR), addressing dissemination and exploitation.

assistant: **Impact**

The present project focuses on the analysis of musical improvisation in South Indian ritual art-music, i.e. the music of oboe/shawm and drum players of the periya mēḷam orchestra. It aims to develop innovative methods, techniques, and tools in order to analyse musical improvisation as a performative and creative process –aesthetically, emotionally and socially significant. Although it would provide an in-depth study of improvisation in which musical along with religious and social functions of Hindu high-castes ritual performance will be addressed, it is above all an attempt to pursue theoretical efforts to demonstrate that musical improvisation is not an allegedly inexplicable phenomenon and can be –at least partially– analysed and explained, by resorting to the hypothesis that a musical act which arises within an improvised performance constitutes at once an opportunity and a frame for the later development of the music that is being played. Furthermore, through a constructive analysis of improvised performances, it aims to assess the strengths and weaknesses of existing theoretical approaches. Our goal is therefore to confront theoretical debates with practical analysis.Our methodology will draw on a wide range of disciplines, notably ethnomusicology, historical musicology, cultural and cognitive anthropology, ritual and performance studies, and sociology. Our analytical method will make use of aural transcription, sequential and paradigmatic analysis, elements of Schenkerian analysis, and will integrate the most advanced software programs specialised in musical analysis. Performers will be involved as far as possible in the research so as to point out quickly problems that challenge any attempt to reconstruct the processes of improvisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Molecular and Genetic Study of the human infections by Capnocytophaga canimorsus'.

assistant: **Objectives**

Capnocytophaga canimorsus are Gram-negative bacteria from the normal oral flora of dogs, which cause rare but  severe infections in humans that have been bitten or simply licked. The most common syndrome is fulminant septicemia with peripheral gangrene.  Mortality reaches 40 % in spite of antibiotherapy and amputations. My laboratory pioneered recently the study of this new pathogen.  We engineered genetic tools, sequenced and annotated the genome and determined the surface proteome of a strain isolated from a fatal infection.  This showed that C. canimorsus have abundant surface-exposed lipoproteins forming a new kind of feeding complexes, some of them specialized in deglycosylating glycoproteins from the host. This property allows C. canimorsus to feed by grazing oligosaccharides at the surface of human cells. The present research program aims at characterizing these deglycosylating complexes, unravelling their role in neutralizing the innate immunity and promoting growth within the host and finally characterizing their assembly at the bacterial surface. Genomic comparisons  will help defining which of these many complexes play a critical role in human pathogenesis.  Besides this, the lipopolysaccharide structure will be determined and genetically manipulated to understand its low endotoxicity and small anti-inflammatory effectors present in the culture supernatant of C. canimorsus will be identified.  Growth in human blood of wild type and mutant strains will be monitored by isothermal microcalorimetry in the hope of developing a surrogate of animal model.  Such a ""virulence"" model would allow to address the question whether all dog's strains are equally dangerous for humans. It would also open an avenue for testing differences in individual human susceptibility. A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An animal model to develop therapeutic strategies for facioscapulohumeral muscular dystrophy, FSHD' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

My primary research interest is to characterize the regulatory pathways controlling muscle-specific gene expression and delineate how they become subverted in disease using Facioscapulohumeral Muscular Dystrophy (FSHD) as a paradigm. FSHD is the third most common myopathy and is characterized by degeneration of selective skeletal muscle groups. FSHD is an autosomal dominant disorder that unlike other neuromuscular diseases it is not linked to a classical mutation within a protein-coding gene. Instead, FSHD patients carry deletions of tandem repeats, termed D4Z4, located on chromosome 4q35. Until recently, an incomplete knowledge of the biochemical pathogenesis of FSHD and lack of an animal model has hampered the development of effective therapies. I found that the 4q35 genes FRG1, FRG2, and ANT1 are inappropriately over-expressed selectively in FSHD skeletal muscle. I identified a silencing element within D4Z4 that contains a binding site for a transcriptional repressing complex. I showed that deletion of this element leads to over-expression of 4q35 genes in FSHD muscle. To identify the gene(s) responsible for FSHD, I generated transgenic mice over-expressing FRG1, FRG2 or ANT1 in muscle. FRG1 mice developed a muscular dystrophy with features characteristic of FSHD whereas FRG2 and ANT1 mice appeared normal. My results also suggest that FRG1 is involved in pre-mRNA splicing. I found that in muscle of FRG1 mice and FSHD patients, specific pre-mRNAs are aberrantly alternatively spliced. I propose that FSHD results from over-expression of FRG1 in muscle, which leads to aberrant splicing of specific pre-mRNAs. My results not only shed new light on the pathogenesis of one of the most important myopathies, but have also provided an interesting model of disease caused by alte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Food for thought: monitoring the effects of drugs and diet on neuronal glutamate release using nanoelectrodes'.

assistant: **Innovation**

Glutamate is the primary activating neurotransmitter in the brain. It modulates synaptic plasticity of neurons, which underlies memory formation. However, it also plays a fundamental role in pathological processes, such as those related to Alzheimer’s disease. This essential role and future development of therapeutic agents urge the development of a highly-sensitive analytical method for determining glutamate levels at a cellular level. In this project I will create a miniaturized, in vitro system that will allow this. To develop it, my expertise in microfluidics and pharmacy will be supplemented by the host’s extensive experience with cell analysis and nanoelectrodes.When glutamate-type neurons in the brain are innervated, glutamate release into the synapse between adjacent neurons occurs. This triggers chemical signal transmission. Nanoelectrodes are uniquely equipped to monitor this neurotransmitter release with unprecedented spatiotemporal resolution. The combination with microfluidics will allow control of fluids and experiments at the nanoliter scale. Furthermore, through precisely fabricated microstructures, guidance of cell growth and precise placement of the nanoelectrodes in the device will be achieved.Glutamate modulates synaptic plasticity, a phenomenon understood to underlie memory formation. Furthermore, dietary compounds and drugs can influence glutamate neurotransmission. The proposed system enables selective exposure of individual neurons cultured in the microfluidic device to such compounds. Using the integrated nanoelectrodes, direct monitoring of their effects on chemical signaling between cells will be possible. The results will significantly contribute to our understanding of glutamate neurotransmission, and how drugs and diet can influence it. Add