RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DURO: Deep-memory Ubiquity, Reliability and Optimization' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

High performance computing has changed the way scientists make discoveries and is driving industrial innovation. From the simulation of the origins of the universe, to the optimization of wind turbine placement; supercomputers are helping us to change the world and improve the conditions of future generations. The next generation of European extreme scale computers brings new opportunities but also imposes new challenge: they need to be an order of magnitude more energy efficient and they need to be reliable so that no data is lost in the presence of failures. Novel deep-memory hierarchies offer an alternative to achieve these resilience and efficiency goals. Unfortunately, it is unclear how the system should utilize these cutting-edge hardware devices. The objective of this project is to build an abstraction layer between the new hybrid memory hardware and the scientific application, providing an easy way to leverage the features of the hardware while maintaining high energy efficiency and strong reliability. Barcelona Supercomputing Centre is an ideal place to carry out this research because of its top-level researchers. In particular, the fellowship will be supervised by Dr. Osman Unsal, who has a long outstanding experience supervising European projects. The combination of such an important project with the high quality training of the host institution represents the best career opportunity for the candidate to expand and solidify his research experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigating a role for the plant hormone, auxin, in coordinating dorsiventral boundary establishment during organogenesis in the model plant, Arabidopsis thaliana', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this project is to understand what controls outgrowth along the margins of leaves and other plant lateral organs. There is evidence that blade outgrowth requires two conditions. One is the establishment of a genetic boundary between the upper (dorsal) and lower (ventral) sides of the leaf organ, which relies on the combined action of polarity genes. The other is the accumulation of the growth promoting phytohormone, auxin. This proposal describes a novel approach to study the expression of relevant genes in living plants in real time, using the model plant, Arabidopsis thaliana. This strategy will allow us not only to follow the fate of individual cells and tissues but also to map the expression of several genes simultaneously. By combining this sophisticated live imaging approach with novel genetic perturbation strategies this study will allow us to gain new insights into one of the fundamental processes of plant growth. Specifically, this proposal will reveal how plants coordinate two key patterning mechanisms during dorsiventral boundary establishment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coupling ATomistics and mesoscAle Plasticity for toUghness of noveL hybrid maTerial' in the context of a Horizon 2020 call.

assistant: **Objectives**

The project is one of an interactive synergism between theoretical modelling at UC Berkeley's MSE department and the CNRS-LEM and multiple length-scale structural/mechanical characterization and innovative processing at UCB. The researcher will lead the project under the supervision of Pr. Asta (UCB) and Dr. Finel (LEM). The work will be done in strong collaboration with Dr. Devincre (LEM) and experimentalist Pr. Ritchie (UCB). As structural materials reach their performance limits, one of the major scientific challenges for the 21st century is the development of new lightweight, high-performance structural materials to support advances in diverse strategic fields from building to transportation or energy. Tomsia and Ritchie have designed a freeze-casting technique to synthesize materials that closely mirror the hierarchical microstructure of nacre, producing the highest toughness ceramics on record. Now, our goal is to improve the material strength as well as toughness. Preliminary results have been recently obtained in the form of Al2O3/Al-Si composites exhibiting high toughness but a strength still 30% lower than pure metal. Our project aims to identify, characterize and model the material fracture, involving physical processes at many length scales and, finally, to design hybrid material with optimized mechanical properties. Our efforts to define the scientific mechanisms needed to develop such new damage-tolerant materials will follow an innovative multi-scale approach: combination of first-principles modelling of the interfaces and micro-mechanics models of bulk elastic and plastic relaxation, together with experimental data.


**Keywords:** metal-ceramic composite, bio-inspired material, mechanical properties, fracture resistance, interface toughness, atomistic m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Metal-Organic Frameworks as multifunctional materials toward P-sustainability' in the context of a Horizon 2020 call.

assistant: **Objectives**

The efficient use of chemical fertilizers is essential to face the Sustainable Development Goal-2: Zero Hunger. Specifically, phosphorous-fertilizers are mainly produced by mining the non-renewable phosphate rock (PR), with both inefficient production and application processes causing dramatic environmental damages. A new European fertilizer regulation encourages the development of new strategies driving to a P-circular economy. Phosphate could be recovered from both waste/eutrophicated water to produce P-fertilizers. However, the prevailing recovery rates cannot satisfy the whole P-demand. Thus, novel methods for a more sustainable production of P-fertilizers are also urgently needed.Zirconium-based Metal-Organic Frameworks (Zr-MOFs) are porous crystalline materials easy to functionalize showing large surface areas, water stability and a strong affinity to phosphate. Hence, they could act as promising P-recovery adsorbents. Besides, they have recently proved to promote the dissolution of highly stable minerals. Thus, they could enhance the dissolution of PR under milder condition, mitigating the environmental risks of PR-mining. Unfortunately, Zr-MOFs are usually prepared using toxic organic solvents, limiting their industrial progress. The project entitled “Metal-Organic Frameworks as multifunctional materials toward P-sustainability” (PSust-MOF) addresses the greener production Zr-MOFs with controlled particle features by using water as solvent. The main features determining both P-recovery process and promotion of apatite dissolution (main component of PR), will be identified. This knowledge will enable the design of advanced Zr-MOF materials which will be tested, for P-recovery or PR-dissolution, under real conditions. It is expected that the results of the project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel Strategies for Cell-based Neural Reconstruction' in the context of a Horizon 2020 call.

assistant: **Objectives**

Neurodegenerative diseases and brain injuries affect large patient groups and carry large unmet clinical needs. NSC-Reconstruct will respond to these needs by developing innovative therapies based on cell replacement, cell reprogramming and circuit reconstruction that have the potential to transform how we treat a wide range of neurological diseases and disorders.In this area of clinical science European research has generated groundbreaking knowledge that has resulted in a pioneering human embryonic stem cell-derived product that is now entering clinical trials for Parkinson’s Disease (PD). In NSC-Reconstruct we will move beyond the replacement of a single neuronal type towards future cell therapies with enhanced authenticity, functions and compositions.NSC-Reconstruct will address PD as an example of disorder for which single neuron replacement has been developed. Our focus in PD will be on incorporating improved cell types and on local network reconstruction. We will also work on repairing long distance networks such as those affected in Huntington’s disease and finally in restoring the complex networks and projections of the cerebral cortex to achieve effective repair in conditions known to affect this structure, such as trauma or stroke.NSC-Reconstruct will lead to (i) the generation of neuronal types with clinically relevant functionality starting from human pluripotent stem cells or through in situ reprogramming, (ii) the optimization of donor cell composition through grafting of functional modules comprising distinct cell types capable of forming appropriate connections, (iii) the restoration of function through the reconstruction of these damaged connections and finally (iv) a greater understanding of the immunogenicity of grafted cells and how this can be mini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DNA interstrand crosslink repair and chromatin remodelling' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

DNA interstrand crosslinks can arise as a by-product of cellular metabolism and, if left unrepaired, they impede DNA replication and threaten genome integrity. Faulty repair of DNA interstrand crosslinks has been linked to Fanconi anemia (FA), a disease characterized by genomic instability and cancer predisposition. The mechanisms underlying DNA interstrand crosslink repair are not fully understood, and it is likely that key regulators of this pathway have yet to be identified. Further, as the proteins involved in DNA interstrand crosslink repair have mostly been profiled using cell-free systems, the impact of chromatin states on DNA interstrand crosslink repair is poorly understood. The main aims of this project are i) to profile the entire repertoire of proteins recruited to DNA interstrand crosslinks in human cells, and ii) to uncover and characterize chromatin proteins involved in DNA interstrand crosslink repair. First, I will develop a pull-down technique to biochemically isolate chromatin surrounding DNA interstrand crosslinks and I will employ it to quantitatively characterise the full spectrum of proteins recruited to these lesions in human cells. This approach has the potential to uncover new regulators of DNA interstrand crosslink repair, including numerous proteins with a function in chromatin biology. I will, then, complement and expand this biochemistry-based strategy using a live cell imaging approach, with the aim of uncovering nucleosome remodellers and histone chaperones recruited to DNA interstrand crosslinks. Finally, the function of new regulators will be dissected using a combination of state-of-the-art microscopy and gene targeting techniques. Together, this work will provide a comprehensive picture of the proteins involved in DNA interstrand cros
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Science communication through immersive media arts: an innovative framework for arts-based science communication' in the context of a Horizon Europe call.

assistant: **Objectives**

Science communication (SC) is more important than ever. The recent COVID-19 pandemic demanded public accountability, clear discussion, and the ability to disagree in public. SC may be essentially defined as the social appropriation of science and technology, enhanced by the integration of science with other beliefs. Therefore, if science can inspire art, can art inspire interest and learning about science? In its turn, how can we make use of artistic expression driven by emerging technology such as 360-degree video, virtual reality, augmented reality or mixed reality as to create innovative and effective arts-based science narratives? In spite of the growing proliferation of collaborative artistic exhibitions, performances, and installations that aim to “activate” science (Schwartz, 2014), it is still unclear whether arts-based science communication (ABSC) is distinctively effective in raising awareness or shaping public policy. Most ABSC projects fail to articulate information about project goals and few projects disseminate performance assessments (Lesen et al., 2016). Thus, this research project is focused on obtaining a systematic understanding of the main objectives, challenges and outcomes surrounding ABSC and whether, and in what ways, these projects set and meet goals, as well as what steps can be taken to foster best practices. By developing, conducting, and critically reflecting upon a series of immersive media ABSC experiments involving scientists, immersive media artists, and the general public, the ultimate goal is to obtain an innovative framework with guidelines and best practices for future immersive media and other arts-science collaborative projects, while further conceptualizing the field of arts-science collaborations, and generating substantial impa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing quantum gravitational physics via inflation' (PQGPCI).

assistant: **Innovation**

Cosmological inflation is currently considered to be the best paradigm for describing the early stages of the universe. The inflationary epoch magnifies the tiny quantum fluctuations present at the beginning of the epoch into classical perturbations that l eave an imprint as anisotropies in the cosmic microwave background (CMB). It has recently been realised that the predictions of inflation for the spectrum of perturbations may not be robust against trans-Planckian (string) physics. Recently, using WMAP, the CMB anisotropies have been measured accurately and it strongly indicate a primordial spectrum that is nearly scale-invariant, just as the inflationary scenario predicts.However, WMAP observations were not sensitive enough to test the non-Gaussianity o f the primordial spectrum and trans-Planckian corrections to the scale-invariant spectrum. It is expected that the sensitivity of the future CMB experiments, like PLANCK, can provide with the form of the corrections to the scale-invariant and stringent constraint on non-Gaussianity of the primordial perturbation spectrum. I am interested in both building and testing new theoretical extensions to standard models. My proposed research strategy is two pronged: development of new theoretical solutions to pro blems of cosmology and to use cosmic microwave background (CMB) as a tool to probe new physics near the scale of inflation.Over the last couple of years, I have been involved in obtaining the power-spectrum, for trans-Planckian inflation, models from the gauge-invariant perturbation theory. I intend to investigate further on the trans-Planckian models to exactly quantify the power spectra and to compare it with the current CMB data. I also plan to investigate non-Gaussianity, along the line of Maldecana (2003), in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sub-THz Surface Acoustic Waves' (STSAW).

assistant: **Innovation**

The rapid development of not only optoelectronics and electrical signal processing for information and communication technologies, but also fundamental/applied science for nanometrology and nanoimaging, requires monitoring coherent surface acoustic waves (SAWs) with deeply sub-optical localization depths in the currently unexplored frequency range of 100 GHz - 1 THz. While bulk acoustic waves can be monitored up to THz frequencies by ultrafast lasers in superlattices (SLs) with nanometer periodicity, the highest SAW frequencies recorded in metallic gratings deposited on surfaces lie below 100 GHz. The use of SLs cleaved along their growth direction for optical SAW excitation has been proposed though not achieved experimentally. The goal of this project is to demonstrate, for the first time, optical monitoring of sub-THz SAWs (STSAWs) by developing original optoacoustic (OA) and acousto-optic (AO) transducers based on such cleaved SLs and an efficient non-thermoelastic OA conversion. Dedicated numerical modeling will optimize the SL design (dispersion characteristics, OA/AO conversion efficiencies) for STSAW propagation, generation and detection. The atomic-precision fabrication of SLs and use of advanced ultrafast pump-probe laser techniques will fulfill this objective. STSAW interactions with charge carriers and 2D materials will be showcased. The project relies on complementarity and knowledge transfer between applicant (numerical modeling, coherent acoustics control) and host institution (SAW theory, laser monitoring of SAWs); it will expand the applicant's experience and skills, shaping the applicant’s career as an independent researcher. Results will be disseminated via networking, conferences and peer-reviewed publications. This project will greatly enhance Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Arthero-Space project: A model based exploration of the regulatory mechanism of the microcirculation for the prevention of orthostatic intolerance' in the context of a Seventh Framework call.

assistant: **Objectives**

Orthostatic intolerance remains a problem upon return to Earth from the microgravity environment of spaceflight. To improve astronaut's countermeasure programs, a better understanding of the response of the cardiovascular system to changes in hydrostatic pressure is crucial. My objective is to assess the regulatory mechanisms of the microcirculation in response to hydrostatic pressure by combining in vivo experiments and 1D blood pressure wave propagation model. At the Aerospace Physiology Laboratory of SFU, I will perform in vivo experiments using a tilt table and a Low Body Negative Pressure set-up to generate a step and linear increases in the hydrostatic pressure. Quadratic increases in hydrostatic pressure will be generated with a Short Arm Human Centrifuge at the Space Physiology division of the DLR. Combining these three protocols will allow me to differentiate responses to abnormal hydrostatic loads (step and quadratic increases) from a linear gradient in hydrostatic pressure normally felt on earth. High resolution ultrasound imaging techniques will be used to measure hemodynamical parameters of large vessels. Concurrently, the theoritical effects of hydrostatic pressure will be implemented in a 1D wave propagation model of blood flow and pressure to simulate the cardiovascular response to the in vivo protocols described above. Furthermore, a fitting process between in-vivo data and simulated data will provide physiological parameters describing the specific vasoconstriction responses of the peripheral bed to the different hydrostqtic loads. The results of this project will bring new insights into the response of the cardiovascular system to changes in hydrostatic pressure which are essential to improve astronaut's training programs and resolve crucial issues in