RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Digital twin for biomass boilers' (DT4BIOMASS) under Horizon 2020.

assistant: **Objectives**

Future biomass boilers face the following challenges in the next years: the improvement of efficiency, the reduction of gaseous pollutant emissions (NOx, CO, HCl and SO2), the reduction of particulate matter emissions, mitigation of problems (fouling, slagging, corrosion) caused by ash deposits formation, flexibility to use different biomass fuels and to adapt to the power demand (start-up time, ramp rates, reducing minimum load). Since the important growth which is expected for this sector in the short/medium term, the enhancement of biomass boilers is becoming more demanded.The manufacturing companies of biomass boilers base their design process in their experience and trial-and-error approaches. Although a reasonable solution can be found with this methodology, it can be far from optimal. Therefore, the digitalization of their design processes is necessary to give a step forward in the biomass boilers design.  Simulation models (based on Computational Fluid Dynamics) have been extensively used to improve the design and operation of fossil fuel boilers. However, the incorporation of these techniques to biomass boiler manufacturing companies is insufficient. The higher complexity of the biomass combustion modelling hinders the access to these techniques (higher cost and expertise required) for this industry sector.In this project Nabladot S.L. aims to develop a comprehensive and accurate biomass boiler model which can be adapted easily to simulate any biomass boiler and, in this way, to overcome the barriers to incorporate this technology to biomass boilers manufacturing/operator companies. Nabladot S.L. has available models to simulate any part of a biomass boiler excepting the fixed bed (or grate), which require the application of complex simulation techniques such a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Citizen-centred EU-EHR exchange for personalised health', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Smart4Health will enable the citizen-centred EU EHR exchange for personalised health. This will pave the way for the full deployment of citizen-centred solutions and services in a digital single market for wellbeing and healthcare. It will provide for interoperability, complementarity and cooperativity with profiles that are currently used e.g. by Member States and regions. Smart4Health will enable the bridging between the diverse EU EHR data and citizen-generated health data. It will connect citizens to science and personalised health services. The European Commission 2017 review of the Digital Single Market lists three priorities: 1) Citizens´ secure access to electronic health records and the possibility to share it across borders, 2) Supporting data infrastructure, to advance research, disease prevention and personalised health and care 3) Facilitating feedback and interaction between patients and healthcare providers, to support prevention and citizen empowerment as well as quality and patient-centred care. Smart4Health addresses these priorities with an outstanding consortium that develops, tests and validates a platform prototype for the Smart4Health citizen-centred health record EU-EHR exchange. Smart4Health provides an easy-to-use, secure, constantly accessible and portable health data and services prototype, thus advancing citizen health and wellbeing, and digital health innovation. Smart4Health builds on the strength of the European infrastructures CEF, ELIXIR, the EIT Health, BBMRI-ERIC, the European Virtual Laboratory for Enterprise Interoperability (I-VLab), the experience and knowledge gained and generated, the EU/US collaboration in eHealth, e.g. the Icahn School of Medicine at Mount Sinai, the momentum of initiatives in the Member States, e.g. 'Medizini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Structure-Function Approach to Understanding the Role of Zyxin' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Cell adhesion to the extracellular matrix (ECM) is essential to the normal functioning of many tissues. At the cellular level, adhesion to ECM regulates a host of activities including cell migration, proliferation and death. A feature of many disease is that cell adhesion to the ECM is perturbed in such a way that control of normal cell function is lost. Cell adhesion to the ECM is mediated primarily through a group of transmembrane receptors (integrins) that cluster into complex, multi-protein structures known as focal adhesions, which link the ECM to the internal actin cytoskeleton.An important function of focal adhesions is the transmission of signals from the ECM to the nucleus, a process that ultimately decides the fate of a cell. One of the key proteins found in focal adhesions is called zyxin. Zyxin is unusual in that it is also found in the nucleus where it is believed to play a role in gene regulation and is thus likely to be a key component in signaling from focal adhesions to the nucleus. This research proposal will use a combination of cell and molecular biology coupled to state-of-the-art biophysical techniques to investigate the nuclear function of zyxin.With the help of a Marie Curie International Incoming Fellowship Dr Patel will not only bring this project with him to the host laboratory, but also his expertise in various state of the art biophysical techniques. One of the most important features of his research is the way in which he employs a wide range of different biophysical methods to tackle biological questions. One of the exciting aspects of this fellowship application is the way in which the areas of expertise of Dr Hotchin and Dr Patel complement each other. The Hotchin laboratory has a strong track record in cell biology and cell adhesion and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Facilitating the next generation of effective and intelligent water-related policies utilising artificial intelligence and reinforcement learning to assess the water-energy-food-ecosystem (WEFE) nexus'.

assistant: **Concept**

Water, energy, food, and ecosystems (WEFE) are interconnected, comprising a coherent system (nexus) dominated by complexity and modulated by climatic and socio-economic drivers. Resource constraints, and their interconnectedness could hamper economic development, including optimal trade, market and policy solutions. Moreover, policy objectives tend to be developed with little consideration to multiple sectors, and policy implementation may change nexus characteristics, in turn affecting actor behaviour and policy formulation. NEXOGENESIS will develop and validate: (a) a coherent cross-sectoral policy-making framework at different scales addressing climate and socio-economic change, as well as stakeholder behaviour and transboundary (diplomacy) issues, developed for and validated by stakeholders, policy makers, and academics; (b) a Self-Learning Nexus Assessment Engine (SLNAE) exploiting reinforcement learning, and supporting streamlining water-related policies into the WEFE nexus; (c) a WEFE Nexus Footprint, accompanying the SLNAE. NEXOGENESIS will apply its approach to four European and one case study in southern Africa. Through the case studies, strong stakeholder engagement and validation of output, NEXOGENESIS will improve policies and policy making processes to enhance cooperation and help the EU achieve targets related to the Water Framework Directive, the greener CAP, Green Deal ambitions, as well as ambitions on water diplomacy. NEXOGENESIS outcomes, both during and after the project, will have a major impact on advancing nexus understanding and governance, resulting in a more innovative and more competitive European Union regarding nexus policy-making, backed up by state-of-the-art evidence. NEXOGENESIS will continue to drive impact after the end of the funding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Efficient Structures and Processes for Reliable Perovskite Solar Modules', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This ESPResSo-project aims to bring the novel emerging hybrid organic-inorganic perovskite-based solar cell (PSC) technology to its next maturity level. In recent years (see Figure 1), this solution-processable solar technology has reached cell efficiency values rivalling those of established thin-film photovoltaic (PV) technology (CIGS, CdTe), even approaching crystalline Si (c-Si) records. The challenge is now to transfer this unprecedented progress from its cell level into a scalable, stable, low-cost technology on module level.The consortium brought together here has alternative materials, insights in novel cell concepts and architectures, and the processing know-how and equipment at hand to overcome these barriers and realize following global objective: Demonstrate a highly efficient (>17%) perovskite-based 35x35cm² module architecture that shows long-term (>20 years) reliable performance as deduced from IEC-compliant test conditions. This module is to be produced with industry-relevant low CAPEX manufacturing techniques validating a potential electricity cost as low as 0.05€/kWh in Southern Europe. Installing an actual building-integrated facade element will validate the potential contribution of this technology to the future European energy supply system. Additionally, prototyping advanced, arbitrary-shaped module architectures with specific materials and process combinations will emphasize that new highly innovative applications like on flexible substrates or with high semi-transparency are well accessible on mid- to longer-term with this very promising thin-film PV technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Understanding the evolution of EXOplanets and towards habitable WORLDs'.

assistant: **Concept**

Exoplanets are planets that orbit stars other than our own Sun. The study of exoplanets provides insight into different stages of life cycles in planetary systems, allowing us to examine planetary physics in a global context. The objective of EXOWORLD is to develop novel detection, characterisation and statistical techniques for understanding the fundamental physics which drives the evolution of planetary systems and find out what set of conditions lead to a habitable world. With next generations of space missions and ground-based instruments on their way, there is an increasing demand for effective approaches in dealing with large exoplanet databases. Improved methods are required to extract information in photometric and spectroscopic data for small signals and push towards the discovery of smaller, lighter planets. As the number of known exoplanets grows, it is also important to analyse planet populations as an ensemble in order to connect observed planetary properties to various planet formation theories. The EXOWORLD network comprises 12 organisations from 8 countries and it will leverage interdisciplinary and international expertise to study the diversity of exoplanets. Secondments will be carried out by both Early Stage Researchers and Experienced Researchers to achieve objectives in four aspects of exoplanet research: detection, characterisation, statistics and habitability. The project will involve a series of training and networking activities aimed at knowledge transfer between participants, enhance individual skills and foster career developments. EXOWORLD will make progress in exoplanet characterisation, and results will be exploited in devising strategic observational and analytical approaches in future missions. Overall, the action will establish a sustai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Breaking resolution limits in ultrafast X-ray diffractive imaging' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Our ability to observe processes and study function at the nanoscale is hindered by the compromise between temporal and spatial resolutions inherent to the majority of far-field imaging techniques. This limits our perspective on a wide range of non-equilibrium processes at the nanoscale such as chemical/catalytic reactions, ultrafast phase-transitions and biological processes at room temperature in native phase.  Intense and spatially coherent femtosecond-short X-ray flashes from free-electron laser (XFEL) sources can combine high spatial and temporal resolutions through 'diffraction-before-destruction' coherent diffractive imaging (CDI) of individual nano-specimens within a single exposure. XFEL CDI studies have found surprising variety of morphologies in soot, unknown metastable shapes of metal nanoparticles and exotic states of water, which are otherwise inaccessible. PI and colleagues applied this technique to follow an ultrafast irreversible laser-superheating process with few nanometers spatial and 100 femtosecond temporal resolutions at the single nanoparticle level.  Despite significant efforts, the spatial resolution of single XFEL CDI images of non-periodic specimen could not be improved beyond few nanometers. This proposal will overcome this limit by exploiting previously little explored phenomena which arise when specimen are exposed to newly available intense 500 attosecond to few femtosecond short FEL pulses. All matter exposed to intense X-rays is photo-ionised. When XFEL pulses are comparable or shorter than subsequent relaxation processes,  non-linear effects such as transient resonances and resonant stimulated emission increase the brightness of images by several orders of magnitudes and significantly improve the spatial resolution.  In combination wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Chemical effluent & oil pollution alert and tracking'.

assistant: **Innovation**

The CLEOPATRA objective is to achieve an integrated chain ( covering research on input data, modelling and output interface) able to feed an advanced service supporting prevention, mitigation and assessment of oil or chemical marine pollution in waters of prime European interest (Mediterranean sea) . It uses the most recent Space Technologies (Earth Observation satellites) and Mateo/ocean scientific research to assist national/regional authorities and organisations concerned with coastal disaster emergency management .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behavior' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Ligand-gated and voltage-gated channels are key molecules in transforming chemical signals into electrical ones and electrical signals into chemical ones, respectively. At excitatory synaptic connections in the brain, activation of AMPA- and NMDA-type glutamate receptors elicits inward currents at the postsynaptic sites, and activation of voltage-gated calcium channels triggers vesicle release of glutamate in the presynaptic sites. Plastic changes in their number, location and property can lead to potentiation or depression of synaptic efficacy, alteration in time course, and coupling to effectors at both postsynaptic and presynaptic sites. These channels are all composed of distinct subunits and their compositions affect channel properties, trafficking to the synaptic sites, and interaction with associated molecules, creating a large diversity of synaptic functions. Although channels with different subunit compositions have been investigated using biochemical and electrophysiological detection methods, very little is known about single channel subunit composition in situ because of the lack of high resolution methods for analysis of protein complex in intact tissues. In this project, I will develop novel technologies to visualize subunit composition at the single channel level in individual synapses by electron microscopy, combining new EM tags, freeze-fracture replica labelling, and electron tomography. Synaptic plasticity will be induced by optogenetic stimulation of identified neurons or behavioural paradigms to examine the dynamic changes of subunit composition. Finally, physiological implications of such regulation of subunit composition will be investigated by genetic manipulation of mice combined with electrophysiological and behavioural analyses. This work will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of hypothalamic circuits for the control of homeostasis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Obesity is a significant global burden that is associated with adverse health outcomes. Adults are not alone in their struggles with obesity. Children now accumulate fat at an alarming rate, making childhood obesity a major health problem. Unfortunately, we do not know enough about the pathophysiology of these conditions to propose appropriate prevention strategies and more effective therapeutic approaches. In this ERC StG proposal, our goal is to discover the developmental processes important for proper con-trol of energy homeostasis. We will study Agrp and POMC neurons, located in the arcuate nucleus of the hypothalamus, that are heavily involved with control of energy homeostasis. Agrp and POMC neu-rons have delayed postnatal development, maturing their axonal projections around the third postnatal week in rodents. Here, we will study in detail this late ontogeny of Agrp and POMC neurons. In Aim 1, we will use novel approaches to measure Agrp and POMC neuronal activity during mouse development in response to nutrients and hormones involved in energy homeostasis. In Aim 2, we will use whole-brain imaging techniques to determine the anatomical development of Agrp and POMC neuronal projec-tions. We will also study the importance of a specific neuronal circuit in neonates to the development of obesity. Finally, in Aim 3, we will identify critical molecular mechanisms involved in the ontogeny of Agrp and POMC neurons by investigating their translatome over the course of postnatal development. Overall, this project will provide novel insights into Agrp and POMC neuron development in conditions relevant to childhood obesity and metabolic dysregulation. The functional, anatomical and molecular mechanisms illuminated here will provide the foundation for future studies aimed t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Tackle Insecurity in Marginalized Areas' in the context of a Horizon 2020 call.

assistant: **Objectives**

The MARGIN project coordination activities are intended to contribute to the creation of sustainable modes of cooperation between stakeholders dealing with security issues. The project provides policy makers with evidence-based tools for developing and assessing strategies targeted at the reduction of insecurity among different demographic and socioeconomic groups. It sets up an international environment for knowledge exchange involving some of the leading EU institutions in Crime Victimization Surveys (CVSs). Along with police statistics, CVSs have become an internationally recognized tool for identifying and analysing factors affecting public and personal perceptions of insecurity. Perception of insecurity arises as a very heterogeneous concept not limited to actual crime rates but encompassing a wide range of other aspects including personal wellbeing, trust in public institutions, justice and social integration. MARGIN addresses the topic of insecurity by taking into account its heterogeneity. Based on previous and on-going research activities, the project's specific aims are: (1) to create a framework enabling end-users to contrast objective and subjective measures of insecurity (i.e. compare police statistics with CVS data), (2) to develop and validate a thematic survey with a sample of 15.400 citizens that allows for the assessment of the impact of demographic, socio-economic and socio-geographic variables on the perception of insecurity (3) to investigate the socio-cultural determinants of insecurity perception through the implementation of anthropological fieldwork in five EU countries (4) to share best practices and outcomes in a final event with 100 key end-users. By deepening the understanding of the root causes of insecurity, MARGIN is expected to foster th