RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New environmentally friendly rare earth colours for ceramics and glass' (RECOLOUR).

assistant: **Concept**

Objectives and content Most of the coloured pigments and colours used to decorate ceramic and glass articles contain transition metals and/or heavy metals in order to achieve the colour and temperature stability required. Consumer protection and workplace health and safety issues make the use of these elements undesirable in these applications, i.e. articles in contact with foodstuffs. Manufacturers and users need to find alternatives in order to meet the increasingly more demanding legislation concerning consumer protection, health and safety and environmental issues. There is an urgent need therefore to find alternative pigments and colours, which are less toxic and more environmentally friendly. This proposal addresses these needs directly and will have a profound effect on industry and the consumer. The objective of the work proposed is to research and develop a range of new pigments based on rare earth compounds and using lead and cadmium free fluxes. Many of the rare earth, lanthanide series of elements are significantly less toxic than the transition metals and are now capable of being produced at a comparable cost. A consortium assembled from 5 EU member states has the expertise to carry out the research necessary and also the experience and capability to transfer the technology to industry and ultimately exploit it fully. It is envisaged that this new technology will be easily integrated into current production practices, to the producer of tableware, tiles or sanitaryware products the use of these products will be no different to the current materials but will have the advantage of being less hazardous. The work proposed will take 4 years and cost a total of 2.5 MECU. The initial work will investigate characterise and optimise the pigments and colours produced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reach  α-synuclein-dependent neurodegeneration: clinical development of therapeutic AFFITOPE vaccines for Parkinson’s disease and multisystem atrophy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The goal of SYMPATH is to advance clinical development of therapeutic vaccines targeting α-synuclein (aSyn)-driven neurodegenerative diseases (ND). It addresses Parkinson’s disease (PD) and multiple system atrophy (MSA), two synucleopathies, for which no causal therapy exists. Ultimately, both lead to patient disability and death, which along with patient number (PD) and age of onset (MSA, PD) define their high medical need status.The proposed programme focuses on 2 vaccine candidates, PD01A and PD03A, delivered by the innovative AFFITOME® technology. Both are peptide-protein conjugate vaccines and first-in-class candidates. They were selected to elicit antibodies neutralizing aSyn but sparing compensatory β-synuclein. Pre-clinical evaluation confirmed their disease-modifying activity in various models. The unprecedented clinical approach, called TANDEM strategy, uses the synergy resulting from applying 2 vaccine candidates in 2 complementary indications linked through their pathology. TANDEM PD/MSA capitalizes on (i) excellent clinical research centres and their associated national/European networks, (ii) platform methods assessing aSyn species as candidate biomarkers and (iii) preliminary clinical experience with PD01A, the first aSyn targeting vaccine ever tested in humans. Its core is formed by 2 phase I studies testing PD01A in MSA and PD03A in PD/MSA. Importantly, trial design (duration, endpoints, vaccine dose and schedule) will ensure collection of initial biomarker data connecting clinical results of PD- and MSA trajectories. SYMPATH defines the logical next development step of both AFFITOPE® vaccine candidates for synucleopathies and generates information/material (biobank) rendering them more amenable to rational drug development. Successful completion of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'GREen Turboprop Experimental Laminar Flow Wind Tunnel Testing' to be submitted under Horizon 2020.

assistant: **Abstract**

The proposal addresses the themes outlined in Topic “JTI-CS2-2016-CFP03-REG-01-02 Green Turboprop configuration - Natural Laminar Flow adaptive wing concept aerodynamic experimental validation (WTT2)”. The objectives of the GRETEL project is the design, manufacturing, testing and WTT support of an innovative large scale (1:3) flexible Natural Laminar Flow (NLF) wing model that is equipped with innovative morphing capabilities on the Leading Edge (LE), Trailing (TE) and Winglet devices and will act as a precursor for the morphing technology implementation on the next generation regional aircrafts. Wing morphing is considered one of the major technological developments towards NLF wings, turbulent skin friction drag reduction and load control, aiming to increase the aerodynamic efficiency in cruise and in off-design conditions (climb, descent). The large scale NLF wing model will be fully functional and representative of the actual wing structure, ensuring that the morphing wing model deformation and its static, and dynamic / vibration response will be representative of those of the actual wing at specified flow conditions. Special emphasis will be placed on the flexible skins sizing in order to structurally optimize them such that the deflected surfaces match as close as possible the aerodynamic surface shapes of the full scale wing. The wing model, with all the morphing devices integrated, will be subjected to Ground Static and Vibration Testing as well as to functional Testing to validate its performance. Subsequently, the large scale wing NLF model will be fully instrumented and delivered to the WT facility to verify the concept of the morphing laminar wing in a representative operational environment up to TRL 6. The innovations achieved within GRETEL will result in i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SELF-BOUYANT PRECAST CONCRETE FOUNDATION FOR THE CRANELESS INSTALLATION OF COMPLETE OFFSHORE WIND TURBINES: FULL SCALE OFFSHORE PROTOTYPE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The offshore wind market is a young and rapidly growing market, whose current project pipeline for 2025/30 would equal nearly 80 nuclear plants, mostly in Europe. The next decade and beyond may average 1,000 offshore towers/year worldwide, with an overall investment volume around 15-20.000 M€/year. This growing sector faces technological challenges, as it is set to move into deeper waters further offshore while being able to reduce the costs in order to reach a competitive LCOE (levelised cost of energy). For water depths above 40m (70% of the future market) approximately 40-50% of investment corresponds to the substructure (foundation and tower). Therefore a significant cost reduction in foundation/tower would drastically improve the overall cost of offshore wind energy. This project intends to develop and demonstrate in operative environment a full scale prototype of a revolutionary substructure system for offshore wind turbines. The concept consists in a self-installing precast concrete telescopic tower which for the first time ever shall allow for crane-free offshore installation of foundations, towers and turbines, thus overcoming the constraints imposed by the dependence on offshore heavy-lift vessels. It will allow for a full in-shore preassembly of the complete system, which is key to generate a highly industrialized manufacturing process with high production rates and optimized risk control. The main benefits expected are:• 30-40% cost reduction (both CAPEX and OPEX).• Large water depth applicability range for deep offshore (>45m water depth). • Supports increased turbine size (5-8MW).• Allows for large scale fast industrial deployment of foundations.• Reduces dependence on costly and scarce installation vessels.• Improved asset integrity (durability) This solu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Oral Off-patent Oncology Drugs for Kids'.

assistant: **Objectives**

There is an urgent need for appropriate oral formulations of anticancer drugs for the treatment of paediatric malignancies in children. The goal of the O3K consortium is to develop oral liquid formulations of Cyclophosphamide and Temozolomide, important chemotherapeutics which have been identified in the list of paediatric needs by EMEA (EMEA/197972/2007). Both off-patent drugs are widely used orally for the treatment of childhood cancer. However, the currently available tablets (Cyclophosphamide) and capsules (Temozolomide) are not suitable for use in a paediatric setting, particularly in infants and young children, as it is often impractical for them to be swallowed. This is a major health concern since these children do not readily have direct and safe access to these curative drugs. The NODS® technology represents an innovative oral drug delivery system for drinkable products for children. Drug entrapment in NODS® particles provides gastroprotection, stabilization, chemical protection of labile compounds and taste masking. O3K will conduct the pharmaceutical, clinical and pharmacological studies required for the development of these oral liquid formulations. Upon completion of the project, a dossier containing data required for application for a Paediatric Use Marketing Authorisation (PUMA) will be filed for both products. The EMEA Scientific Advice is already ongoing. O3K will provide access to curative drugs for all children with cancer, improving compliance, ensuring safety for both patient and environment and allowing the development of essential ambulatory treatments. In accordance with ICH guidelines, the development of these agents will lead to improved quality and safety of paediatric drug formulations. The O3K project involves 9 partners (including 5 instit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Understanding the functional role of Immune-related Intercellular Signalling Networks during tissue Development and Cancer'.

assistant: **Objectives**

Intercellular signalling networks drive tissue fundamental processes. Immune cells present a wide range of versatile functions and distinctive plasticity, which position them as tissue signalling-hubs during tissue development, homeostasis and cancer. Recent genomic advances have greatly improved our understanding of cell composition and states; however, investigation of the molecular signatures of intercellular crosstalk at the single-cell level remains limited. Exploring tissue development, homeostasis and cancer from the point of view of immune-controlled signalling networks, has the potential to reveal novel therapeutic candidates with high biological and medical impact. By applying functional assays alongside novel single-cell RNA-sequencing technologies and computational approaches, as physically interacting-cell sequencing (PIC-seq), I propose to crack the functional consequences of the whole-tissue signalling networks to revisit key developmental and cancer immunology questions:1) What immune-related intercellular crosstalk drives tissue development and cancer? We will integrate scRNA-seq and PIC-seq analysis along mouse lung, liver and kidney development, and human carcinomas, and apply large-scale comparative cross-tissue and cross-species analysis, ex-vivo and in-vivo studies, to identify tissue-exclusive and shared signalling during tissue physiology or cancer.2) What can we study on tumor-escape mechanisms, based on physiological signalling networks? We will perform development versus cancer large-scale molecular comparisons, in-vivo cancer models for functional perturbations, and clinical validations, to identify novel immunotherapy targets. Successful completion of the project will reveal novel cancer and developmental immunotherapy targets. Concomitantly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mediterranean desertification and land use Project 3: regional indicators', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The overall goal of Project 3 is to develop a set of regional indicators which provide a planning tool for application to desertification at regional, national and European scales. This will be achieved through a set of four closely linked modules which are integrated into the overall structure of the MEDALUS III project.In Project 3, the target areas identified within MEDALUS are used to identify Environmentally Sensitive Areas (ESAs) through regional indicators, and develop a broad scale methodology, relying principally on Remote Sensing but also making use of other regional data as and where available, to identify and prioritise degradation risks on a pan-European scale. There are strong cross-links with other MEDALUS projects, particularly in defining target areas (Project 1) and ESAs (Project 2). The first module develops the physical scientific basis for the regional indicators proposed. A one-dimensional model for hydrology, vegetation (cropped and uncropped, including the effects of grazing) and soil erosion is being developed for interpreting regional data and extending it in a forecasting framework for the coming decades. Development of existing research on remotely sensed images will provide data on regional scale changes in vegetation and land use to provide a relevant time series for model calibration. Comparable regional data on climatic time series will be provided by from METEOSAT data. These three components provide the core methodology for implementation of the model as a forecasting tool. The development of regional economic and social approaches to desertification (module 2) is much less well advanced in MEDALUS than the physical modelling, and relies crucially on socio-economic data collected and provided by the Project 2 groups. The core of module
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Meso-level eco-efficiency indicators to assess technologies and their uptake in water use sectors' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

EcoWater will address the development of meso-level eco-efficiency indicators for technology assessment through a systems' approach. The effort will focus on enhancing the understanding of the interrelations of innovative technology uptake in water use systems, and their economic and environmental impacts. Research will address the selection of indicators appropriate for assessing system-wide eco-efficiency improvements, the integration of existing tools and assessment methods in a coherent modelling environment, and the analysis and characterisation of existing structures and policies. The development of an analytical framework is foreseen, to support: (i) Systemic environmental impact assessments, (ii) Economic assessments, (iii) Analysis of value chains and actor interactions, and (iv) Technology implementation and uptake scenarios. Eight Case Studies will be developed, in different systems and sectors of high economic relevance and environmental impact, addressing water use in agricultural, urban and industrial sectors. Two Case Studies will focus on shifts from rainfed to irrigated agriculture and innovations that can reduce water and energy footprints and production inputs. Two Case Studies will address sustainable and economically efficient water supply and wastewater management in urban areas. Four Case Studies will concern meso-level eco-efficiency improvements from innovative technologies in water systems for the textile industry, for energy production, for dairy production and in the automotive industry. The main outputs include a validated and tested methodological framework, an integrated toolbox for systems' eco-efficiency analysis, and policy recommendations for technology uptake and implementation. For ensuring wide dissemination and applicability, the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Preparing ESNII for HORIZON 2020' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Preparing ESNII for HORIZON 2020The aim of this cross-cutting project is to develop a broad strategic approach to advanced fission systems in Europe in support of the European Sustainable Industrial Initiative (ESNII) within the SET-Plan. The project aims to prepare ESNII structuration and deployment strategy, to ensure efficient European coordinated research on Reactor Safety for the next generation of nuclear installations, linked with SNETP SRA priorities.The ESNII+ project aims to define strategic orientations for the Horizon 2020 period, with a vision to 2050. To achieve the objectives of ESNII, the project will coordinate and support the preparatory phase of legal, administrative, financial and governance structuration, and ensure the review of the different advanced reactor solutions.The project will involve private and public stakeholders, including industry, research and academic communities, with opened door to international collaboration, involving TSO.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The new technology of intermetallic phases treatment by fluid flow in Al-Si casting alloys' under Seventh Framework.

assistant: **Concept**

Aluminum-silicon base alloys are widely used in castings (foundry industry) due to their excellent castability and high strength-to-weight ratio. In the Al-Si alloys, the presence of small amounts of Fe and Mn brings about a complicated microstructure due to the formation of a rich variety of intermetallic phases (IMPs) during solidification, which generally have a negative effect on the mechanical and physical properties of a as cast part. The main goal of the project “iPhaseFlow” is to prepare new technology of intermetallic phases treatment by fluid flow in Al-Si casting alloys. The project investigates problems of artificial fluid flow influence on the growth, morphology and spatial arrangement of intermetallic phases in as-cast AlSi-base alloys containing especially Fe and Mn as alloying elements. The “iPhaseFlow” studies concerns detailed tasks: directional solidification of casting specimens in Artemis aerogel furnace by the presence of fluid flow and without it (in different solidification conditions), detailed analysis of the microstructure of the Al-Si alloys (dendritic pattern geometry, length and thickness of the IMPs, localization of the IMPs, their density and shape distribution), numerical modeling for physical understanding of the mechanisms leading to the anticipated changes in microstructure by the presence of IMPs and fluid flows. Project involves trainings in using advanced world wide unique facilities and modern scientific methods: directional solidification within Artemis, microstructure investigation by methods SEM/EBSD/EDX, x-Ray nano-tomography, x-Ray diffractrometry, metallography, quantitative image analysis (AnalySIS, Origin, IDL) and thermal analysis DTA, DSC. “iPhaseFlow” will be conducted in Institute of Materials Physics in Space MP of th