RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Linking Sino-European Research Institutions in the Mobile Cloud Computing Era'.

assistant: **Concept**

Mobile Cloud Computing emerges as a new computing paradigm where mobile devices exploit the available cloud computing platform for performing specific tasks and/or accessing data on demand rather than on the individual devices themselves. A key element missing in current mobile cloud computing design is the need of sufficient consideration on mobile network bandwidth availability and energy consumption for both cloud computing devices and mobile devices. MobileCloud project aims to bridge this gap, addressing how mobile cloud computing services can be delivered in such environments in a highly efficient and energy-efficient manner.The proposed joint exchange project aims to provide a stimulating and structured platform for the exchange of researchers and for the joint development of innovative ideas in the emerging areas within mobile cloud computing and beyond. To achieve this goal, a broad combination of eight universities and research institutions in Europe and China will collaborate together and create a multidisciplinary (cloud computing, mobile computing, telecommunications, computer systems and network optimization) and international (China plus four EU member states) environment for an innovative research experience and knowledge exchange in mobile cloud computing. The specific S&T objectives of MobileCloud are to jointly investigate innovative methodologies and approaches to optimize mobile cloud computing resources and satisfy service requirements including energy efficiency and high resource utilization in the emerging cloud computing era.Our team comprising researchers with complementary expertise is very well positioned to design, develop and evaluate the mobile cloud computing technology, contributing to a new low-energy, scalable and highly efficient netw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Vertical restraints and competition policy - the case of multibrand retailers' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Many relationships between manufacturers of goods and their distributors (e.g. wholesalers and retailers) are governed by distribution contracts that stipulate certain obligations for one or both parties, thereby limiting in some way their commercial freedom. These obligations are commonly referred to as 'vertical restraints'. The economic literature has considerably improved our understanding of the impact of vertical restraints on competitions between brands and among distributors. A drawback of the current literature is, however, that research on the subject has almost entirely been carried out in the context of competing single-product retailers and in the context of retail monopolies. Very little research has been done yet in the context of competition between retailers each carrying a similar assortment of products and brands (between 'multibrand retailers' ), although it is a context that actually applies to many goods markets. The central objective of the research project is to obtain a closer understanding of the impact of exclusive dealing arrangements and of resale price maintenance provisions in the context of multibrand retailers, using a spatial competition model. On the basis of this analysis (and the subsequent analysis of case law) suggestions for European competition policy will be formulated. Considering the outstanding reputation of many of the institute's scientists in the domain of contract theory and vertical restraints (a.o. Rey, Tirole, Martimort and Cremer) and the fact that I will be under the direct supervision of Professor Rey, it is hard to think of a better place to do this research project and to develop the skills necessary for future research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Polymer Injection Advanced Moulding'.

assistant: **Innovation**

Injection Moulding is one of the main polymer forming process, offering high volumes, high precision and high added values. Polymer parts are used for large consumption applications (automotive industry, domestic and electric applications, toys...) but also for sophisticated high technology products (electronic devices, biomedical implants, lenses, optic fibres connectors, DVD...). Part dimensions range from very large size (automotive dashboards) to very small ones (micromechanics, electronic components...). Polymer converters are numerous (and relatively scattered) in Europe, close to 30000 companies, often SME, involving over one million employees. In classical" injection moulding, there are increasing demands for process control, dimensional stability and properties insurance. More demanding are "emerging technologies" such as micro products or large size parts but with surface reproduction at the micro scale. Strong limitations remain due to a lack of knowledge of the physics of these small-scale non-equilibrium processes. Only a combined effort of advanced numerical and experimental expertise will allow significant improvements in these two domains. The Pam Coordination Action Proposal aims at initiating a wide consortium of European experts involved in all aspects of the injection moulding process (processing, material science, physical and numerical modelling, mechanical properties...). These experts belong to academic and industrial research centres, but also to technological research centres, which are closely connected, to SME. Putting together this wide range of expertise will result in setting the basis for the development of a new generation of predictive tools for polymer injection moulding accounting for the more achieved physical models and numerical te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Warming Impacts on Estrogenic and Progestagenic Endocrine Disruptors Effects in Fish Liver - A Proof of Concept Study Using Single- and Novel Multi-Cell 3D Cultures of the European Native Brown Trout' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In recent years, an increasing number of emerging pollutants were identified in aquatic ecosystems, and one of the major concerns is the presence of sex-steroid hormones and mimics which act on aquatic organisms as endocrine-disrupting compounds (EDCs). The proposed multidisciplinary project will have focus on in vitro testing of complex of EDCs mixtures: the EU watch listed pollutant ethinylestradiol with emergent progestins drugs (levonorgestrel and megestrol acetate), taking into account a standard versus a warming scenario, as a major global change issue. This will be done by developing and exploiting cutting edge in vitro fish toxicity test tools: single-cell and (new in fish studies) multi-cell type 3D spheroids of liver cells (hepatocytes, stellate cells and biliary epithelial cells) of brown trout (Salmo trutta). The project will explore the advantages of 3D cultures, which have been proved to be much more biologically realistic than common 2D cultures, in order to study: (i) their morphology and viability using light and electron microscopy, including immunocytochemistry; (ii) multi end-point biochemical assays in combination with Raman microspectroscopy (novel in 3D culture); (iii) mechanistic insights of disruption and eventual (still unavailable) biomarkers of fish exposure/effect as to progestins. Quantitative gene expression is the method of choice for this task, targeting specific genes related to lipid-metabolism, yolk and eggshell proteins and androgen/estrogen/progestin receptors. An additional innovative contribution of this project is developing new tolls for enforcing the 3Rs (Replacement, Reduction, and Refinement) in fish research. The project will bring to another level the collaboration between the applicant and the host mentor by bidirectional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Animal and Human Nutrition Benefits of Nature Identical Vitamin E' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of this project is to use exchange of staff on an international and inter-sectoral basis to investigate the impact of consumption of novel nature-identical RRR-α-tocopherol in animal models on nutritional quality of animal-derived foods and in human models on bioavailability and circulating stereoisomers, and in doing so to foster a culture of research and innovation that will underpin new innovative products, services and processes in the area of animal and human nutrition. Vitamin E is represented by a suite of 8 compounds – 4 tocopherols (α, β, γ, δ) and 4 tocotrienols (α, β, γ, δ).  The main function of vitamin E is as an anti-oxidant, preventing free radical-mediated lipid oxidation, particularly of membranal lipids. α-Tocopherol is the most biologically active form  but α-tocopherol itself exists in 8 stereoisomeric forms arising from the 3 chiral centres it contains, RRR, RRS, RSR, RSS, SSS, SSR, SRS and SRR.  Of these RRR-α-tocopherol is the most biologically active form.


**Keywords:** Vitamin E, Food Trials, Animal Studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Axonuclear communication in health and disease' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

We postulate a novel cell biological mechanism termed axonuclear communication which functions to link glial cell cytoplasm with neuronal cell bodies via transfer of protein-synthesizing units and mRNA from glia to axon, local protein synthesis of critic al components in the axon, and importinmediated axonal retrograde transport of the signaling complexes thus created. Our central aim is to understand and control axonuclear communication to eventually allow support and therapeutic intervention for diseas ed and damaged nerve cells via engineering critical steps along the glia-axonneuronal cell body route. We will elucidate the mechanisms involved in glia to axon transfer of ribosomes and importin transcripts and their local translation, and in importin-ta rgeted retrograde trafficking along axons to the neuronal cell body and nucleus. In addition we will examine the involvement of axonuclear communication in motor neuron disease, in viral invasion of the nervous system, and in neuropathic pain mechanisms. The potential impact of understanding and controlling axonuclear communication is significant both in terms of basic understanding of how the nervous system works, and in terms of potential downstream applications in a range of clinical settings. The lat ter include the very exciting possibility of utilizing the system for targeting therapeutic support or gene therapy to the brain. One may conceive using axonuclear communication mechanisms to target desired molecules from the periphery to specific locati ons in the CNS, or to improve delivery of a neuroprotective gene to defined neuronal populations. The extreme difficulty of transfecting neurons with exogenous genes is well known, and therein lies perhaps the most promising impact of the project, if we can develop kno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Trafficking of DC in Wiskott Aldrich syndrome', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The spatial and temporal distribution of dendritic cells (DC) is essential for the initiation of specific immunity and tolerance. Patients with Wiskott Aldrich Syndrome (WAS) show loss of WAS protein (WASp) function, resulting in impaired immune cell migration and abnormal splenic architecture. Ongoing studies of the host laboratory suggest that DC migration to inflamed tissue and to draining lymphoid tissue is compromised and accompanied by exaggerated production of pro-inflammatory cytokines, such as IL-1 2 and IL-6 in vitro. We hypothesise that deficient DC migration may impair normal immune cell distribution in lymphoid tissue and influence subsequent immune function.We therefore aim to determine the role of WASp in DC biology and its specific role in DC migration.1. We will study the role of WASp in the distribution of DC subsets and their cytokine expression in response to TLR stimulation.2. We will investigate whether and how WASp regulates the migration and localisation of DC in steady state and in inflammatory conditions.3. We will use two-photon laser microscopy to study the real time migratory behaviour of WASp-/- DC and their interaction with other immune cells.We expect this project to have profound impact on my scientific career and more in general in the field of DC biology. Better understanding of the role of WASp in DC migration and in immune function will provide better insight in the immunological pathogenesis of WAS and may provide important information for design of new therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Investigating susceptibility to trypanosomatid parasites using Drosophila melanogaster as a model'.

assistant: **Objectives**

One of the specific United Nations Sustainable Development goals is to end epidemics of neglected tropical diseases by year 2030. Some of the most devastating of these diseases are caused by trypanosomatid parasites that are transmitted to humans via the bites of infected insects from the order Diptera (Flies). While most natural fly vectors pose a challenge to study under laboratory conditions, Drosophila melanogaster, with its well-established molecular, genetic and genomic toolkit and a vast amount of prior knowledge of its biology, is a proven model for experimental studies. Because D. melanogaster is host to several natural parasites that belong to the trypanosomatid group, it can also serve as a model for studying fly-parasite interactions. In this project, we propose to take advantage of the Drosophila melanogaster Genetic Reference Panel (DGRP) to investigate the genetic basis of fly susceptibility to trypanosomatid infection. First, we will perform a genome-wide association study (GWAS) for natural susceptibility to trypanosomatid parasite using a well-developed DGRP mapping resource to map genetic variation in susceptibility. Further, we will also test for differences in gene expression associated with infection susceptibility, using RNA sequencing, and validate the candidate genes identified with GWAS and RNA sequencing. Together, along with the well-annotated Drosophila genome, these data will reveal functional pathways affecting susceptibility to trypanosomatid infection. The established Drosophila-trypanosomatid system can serve as a functional model for insect-vectored diseases in medically and economically relevant species of Diptera.


**Keywords:** Drosophila, trypanosomatids, evolutionary genetics,  host-parasite interaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Iron and Carbon Interactions and Biogeochemical CycLing in Subglacial EcosystemS'.

assistant: **Innovation**

Glaciers have been conventionally viewed as lifeless bodies that have little impact on biogeochemical cycles. It is now known that liquid water is present under all large ice masses. In Antarctica, subglacial lakes and rivers have been discovered. One of these subglacial lakes, Subglacial Lake Whillans, was accessed in 2013, and supports a diverse and metabolically active microbial ecosystem. This raises questions about biogeochemical cycling within these ecosystems. Specifically, the sources, concentrations, flows, modifications and interactions between life essential nutrients. The nutrients sourced from these environments might have an impact on downstream ecosystem productivity. This is of particular importance as the Southern Ocean, which surrounds Antarctica, is the world’s largest high nutrient low chlorophyll region, where iron is the primary limiting element for life. Organic matter is thought to play a major role in regulating the flux and bioavailability of iron, and may also be an important source of bioavailable carbon.The main objective of ICICLES is to investigate the cycling and interactions between iron and carbon (as organic matter) in these unique environments. Iron and organic matter in waters and sediment samples from three sites at the bottom of the Antarctic Ice Sheet will be characterised using state-of-the-art spectroscopic and microscopic techniques. Diatom culturing using these samples will be used to determine potential iron bioavailability to downstream marine organisms, and the effects of organic matter complexation. A new budget of iron and organic matter export, and associated bioavailability, from the Antarctic Ice Sheet will be constructed and utilised with a global ocean model to postulate the impact of subglacial meltwaters on marine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Models of noncommutative differential geometries' (NCDIFFGEO), addressing dissemination and exploitation.

assistant: **Impact**

Quantum spacetime is the idea that spacetime coordinates are not classical variables but elements of a noncommutative 'co-ordinate algebra' much as in quantum theory. The first convincing models of (flat) quantum spacetime appeared in the 1990's, typically on the basis of quantum symmetry using the then-new theory of quantum groups. The thinking is that such noncommutativity should arise from quantum gravity effects and allows us to model these in an effective description without full knowledge of quantum gravity itself (this not being known). Such flat quantum spacetimes are an area of existing strength for EU science. The project proposes a new generation of quantum spacetime models no longer tied to quantum symmetry. Instead the Marie Skłodowska-Curie Fellowship will train an experienced Researcher coming from theoretical physics in new highly algebraic tools which are not easily accessible to physicists and which amount to a mathematical theory of 'noncommutative Riemannian geometry' including quantum differentials, quantum metrics, and quantum-Levi Civita connections and quantum curvature. The realisation of the project will validate and enrich the mathematical formalism and also promises a next generation of physical effects related to the conjunction of both gravity and quantum noncommutativy, which will stimulate original and creative approaches to quantum gravity across several EU institutes. It will also greatly enhance the competitiveness of the Researcher in complementing her knowledge of theoretical physics by mathematics (noncommutative differential geometry) which will put her in a seminal position for subsequent work. The quality and ambition of the research objectives, the possibilities of interdisciplinary collaborations and the international recogniti