RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'IMPROVED RETROGRADE LENTIVIRAL VECTORS FOR GENE THERAPY IN MOTOR NEURON DISEASES' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Lentiviral vectors can be targeted to specific cell types by varying the envelope proteins, a process called pseudotyping. The rabies-G pseudotyped lentivectors are useful for distal targeting of neurons because they are retrogradely transported to the nucleus where they integrate and express the transgene, as first demonstrated by us. Motor neuron (MN) diseases are incurable neurodegenerative diseases causing progressive paralysis and premature death. Most amyotrophic lateral sclerosis (ALS) cases are sporadic, but there are rare inherited forms one of which being due to mutations in the superoxide dismutase (SOD1) gene. Spinal muscular atrophy (SMA) is the second commonest genetic disease affecting children and is due to mutations in the survival motor neuron (SMN1) gene. In mouse models for ALS (SOD1 mutant mouse) or SMA (SMNDelta7 mouse) when we delivered in various muscle groups rabies-G pseudotyped lentiviral vectors expressing either vascular endothelial growth factor or short interfering RNA targeted to a mutated SOD1 gene or the normal SMN1 gene we corrected motor defects and extended survival. Despite these successes, experiments with rabies-G pseudotyped vectors in non-human primates have failed to give good efficiency of transduction of MNs so as to translate this approach to the clinic. Also SMN-1 targeted replacement produced only a marginal increase in survival despite sparing MNs. In this grant we propose: 1) To investigate the molecular pathway of retrograde transport of the rabies-G lentiviral vectors.  This might allow us to increase the efficacy of gene transfer with these vector systems. 2) To design novel lentiviral vectors with tropism to the neuromuscular junction (NMJ) so as to try to increase the efficiency/specificity of gene transfer to MNs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of analytical procedures to guarantee quality assurance in international environmental monitoring' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Foreseen ResultsFollowing an initial evaluation of techniques, the project methodology will be established in terms of reporting analytical procedures and storing results. Sample distribution will be carried out by one partner, who will be responsible for sample quality and data security. An initial analysis phase in which current procedures will be used, will be followed by statistical treatment of data, and evaluation during a first workshop. This will lead to improvements in procedures, which will be put in place during a second phase of analysis, coupled to in depth training at the relevant EU laboratories.Increasing environmental awareness in the CCE/NIS states has brought with it an increased discovery in the number of polluted sites in these lands, and with that a desire to apply the standards and norms which are valid in the EU lands. Harmonization of state legislation with EU legislation has become a goal for many CCE/NIS lands.While geochemical laboratories often are well equipped in CCE/NIS lands, procedures are not standardised and are open to question. The wide range in analytical techniques and methodology available in these laboratories urgently requires that a standardisation of methods be rigorously tested and implemented in order to improve the comparability of measurements.The geochemical laboratories of the geological surveys in the EU and CCE/NIS lands are independent and mostly non-profit making. They have the longest experience of any type of laboratory in Europe in analysing soils, sediments, rocks, ores and minerals, and thus are the most suited for environmental evaluation, and are often consulted in matters of dispute. This project is a concerted action, utilizing existing links to provide support and transfer of technical know-how between the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced Surface Protection for Improved Reliability PCB Systems' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

To investigate the scope, extent and factors causing black pad and related problems on printed circuit boards with an electroless nickel / immersion gold (ENIG) solderable finish . To develop a non-destructive test method to show the presence of black pad. To develop and test lower cost, less aggressive surface protection chemistries as replacements for conventional ENIG using both aqueous and ionic liquid based electrolytes. To introdude these to the European PCB industry and to support the introductiuon of new standards around their use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mapping Internet Routes for Geopolitics' to be submitted under Horizon Europe.

assistant: **Abstract**

The Internet has been able to grow and develop very quickly in most countries because of its highly decentralized nature. Its resilience is based on a multiplicity of different paths that allow data to always bypass a blockage or a partial destruction of the network through alternative routes. This model is today called into question by a combination of dynamics. First, we observe a dynamic of fragmentation along national borders, at the initiative of some states who, in the name of national security, seek to restore control over the borders of what they see as their national cyberspace. Second, at a higher level of abstraction, we observe another dynamic, this time guided by market forces: the concentration of data traffic around a few major players in data routing and a few large platforms. Largely invisible, this concentration also leads to a form of fragmentation along commercial lines. These evolutions raise important issues in terms of cyber stability, resilience, free flow of data and human rights, that are largely overlooked short of scientific knowledge about the geopolitics of Internet data routes. DATAROUTES aims to carry out a cartography of Internet data routes in order to understand how the routing strategies of state and non-state actors shape cyberspace and to analyze, as a domain of application, the important security and policy issues it raises for the European Union. The goals of this project are to measure and map Internet routes using open source data, thanks to DATAROUTES’ Border Gateway Protocol observatory; investigate through field work the strategic goals of state and non-state actors uncovered by the cartography; and analyze the broader policy issues they raise for the European Union in the context of the implementation of the 2020 Cybersecuri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'FORENSIC ARCHITECTURE: The Space of Law in War' in the context of a Seventh Framework call.

assistant: **Objectives**

Although violations of International Humanitarian Law (IHL) and human right (HR) conventions are frequently undertaken in cities and by means that deliberately manipulate the elements that constitute their built fabric, this project contends that organizations of international justice could benefit from a closer engagement with the operational procedures, conceptual assumptions, methodologies, and technologies of urban and architectural analysis. Legal claims of the kind that are brought to international courts and tribunals or made to circulate within the general media often invoke images of destroyed buildings or of menacing new constructions, but these are too often merely treated as self-evident illustrations of atrocity. This project attempts to transform the built environment from an illustration of alleged violations to a source of knowledge about them and as a resource through which controversial events and processes could be reconstructed, analysed and better understood. To be undertaken at the Centre for Research Architecture, a multidisciplinary group of spatial practitioners directed by the PI, the project will employ new technologies and novel forms of spatial analysis in order to query the function of space as evidence within the different forums of international justice. The project is organized around the investigation of several legal controversies, each with a distinct spatial dimension. The project is driven by the introduction of a new operative concept    Forensic Architecture  (FA)   which is proposed as a new field of practice and as an analytical method for probing the political and social histories inscribed in spatial artefacts and in built environments. The project will result with web-based interactive platform, an exhibition accompanied by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Optimal Mechanisms to Match Supply and Demand in Contemporary Supply Chains' in the context of a Seventh Framework call.

assistant: **Objectives**

Emerging production and information technologies have increased competition and consumer expectations, this leads to ever-shrinking product life cycles, volatile and unpredictable markets.  In addition, natural disasters, accidents, supply disruptions increased the risk in today’s global and long supply chains.  Keeping costs down and customers satisfied in a global marketplace requires companies to proactively manage supply and demand using state of art techniques, technologies and practices.   This proposal describes a research program for building novel optimization models and efficient solution mechanisms that enable contemporary supply chains to optimally match demand and supply through demand management and sourcing decisions. The resulting modeling, analysis, and algorithmic development will also contribute advances in applied optimization theory and large-scale problem solving.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a commercial concept for variable speed operation of unregulated submersible compact turbines' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The scientific and technical objectives of the project are:- to develop, optimise and test a commercial concept for VSO of unregulated submersible compact turbines - to redesign a runner, intake and guide vanes for VSO- to apply a new frequency converter concept for grid connected and stand alone operation (e.g. for rural electrification)- to develop a new direct coupled permanent magnet generator with water cooling- to prove feasibility of the VSO concept- to reduce electricity cast at low head hydropower sites- to increase the flexibility and operation range of the compact turbine series- to develop a site specific software design tool for the proposed turbine concept based on efficiency and duration curves
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Discovery of breast cancer aggressiveness markers using topo-proteomics mapping' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In the proposed research we will explore the functional proteomic diversity of histologically-defined regions within human breast tumors, aiming to identify novel protein biomarkers of tumor aggressiveness. Once identified, these proteins will serve as potent diagnostic markers and therapeutic targets. Towards this aim we will perform genome-scale proteomic profiling on tumor regions displaying diverse histopathology. This will be followed by functional investigation of these cancer cell sub-populations to determine their tumorigenic potential, and search for microparticle-based proteomic biomarkers from serum samples towards identification of cancer aggressiveness in blood tests. Analysis of the proteomic diversity holds a promise to reveal yet unidentified regulators of the tumorigenic phenotype as quantitative protein profiling is expected to most faithfully predict cellular phenotypes. This will be accomplished using the 'super-SILAC' technology, which I developed during my post-doctoral research. Using this technology, we identified over 12,000 proteins in formalin-fixed paraffin embedded breast cancer tumors. In the current project we will take one large step further, namely, microdissect and analyze selected regions in breast tumors based on local histopathological characteristics, such as the expression of known markers, cancer cell density, the vicinity to blood vessels and to the tumor invasive front. This ""topological map"" of the proteome will be followed by functional in vitro and in vivo studies, directly probing the aggressiveness of these cell populations, manifested by an accelerated proliferation and invasive/metastatic capacity. Finally, proteins associated with tumor aggressiveness will serve as blood-based biomarkers for predicting the tumorigenic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel Resolvin D3: its Role and Actions in the Resolution of Aortic Valvular Inflammation and Stenosis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Aortic valve stenosis is a progressive inflammatory disorder with poor prognosis if left untreated. Currently the only available treatment is invasive surgical replacement of the valve, therefore new therapeutic strategies are needed. Resolution of inflammation is an active process orchestrated by endogenous specialized proresolving lipid mediators (SPM). These include the resolvins that actively promote catabasis via their potent actions in anti-inflammation, proresolution, tissue regeneration and pain reduction. Recently the complete stereochemistry of resolvin D3 (RvD3) was established. Given its highly potent anti-inflammatory and proresolving actions in murine models and with human cells its role and actions in aortic stenosis (AS) remains to be uncovered. Thus, a goal of this proposal is to elucidate endogenous resolution programs in human aortic valves and define the role and action of RvD3 in AS and calcification. To address this the candidate will employ LC-MS-MS based LM metabololipidomics combined with clinically relevant parameters as well as biochemical and cellular assessments in samples from AS patients. In addition, RvD3 will be used as treatment in a novel preclinical model of murine AS. Implementation of the proposed project will maintain and enhance the candidate’s position at the forefront in the field of resolution biochemistry with advances into valvular pathology. Unraveling the role of RvD3 and resolution programs in aortic inflammation and resolution may enhance current understanding of the molecular mechanism contributing to chronic cardiovascular inflammation and introduce a novel concept for the pathology AS. Furthermore, it may lead to novel therapeutic strategies with a potential to slow or halt the hemodynamic progression of stenosis via t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Natural, health-benefiting fabrics to protect our skin from external agents' (PYRATEX).

assistant: **Innovation**

Today, society is increasingly exposed to environmental pollution: UV radiation generate 90,000 new cases of skin cancer annually in Europe and 7m people die prematurely from exposure to air pollution. Current solutions to protect the body from environmental factors require the daily use of expensive cosmetic skin creams, which are time-consuming to apply for today´s busy society. Our clothing is also a potentially powerful tool to protect our bodies from external agents. However, current fibres from which textile fabrics are made are either synthetic or natural but treated with chemicals/ additives that are harmful for environment and our body. There is a necessity to find a natural and additive- free fabric that provides the body the protection needed against environmental agents. In response, our company Pyrates Smart Fabrics (Pyrates) has developed, PYRATEX® COSMETIC and PYRATEX® HEALTH (PYRATEX) are unrivalled additive and chemicals -free fabrics made of natural fibres. They are manufactured via a sustainable and traditional process enabling the final textiles to take care of the skin and body by providing protection against UV radiation (PYRATEX® HEALTH) and air pollutants (PYRATEX® COSMETIC). PYRATEX organic and natural fabrics avoid the use of 19,500 tons of dyes per year and unlock total customer value of €15m by year 5 after launch. Having validated the reliability of the PYRATEX® COSMETIC and PYRATEX® HEALTH fabrics at the pilot scale, we now want to finalise its development and achieve market preparedness. In Phase 1 we aim to carry a Feasibility Study to warrant the project from a technical, commercial and financial point of view. Besides the crucial benefits that it will bring to natural textile sector, PYRATEX will boost the growth of Pyrates, expecting t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dressing the New World. The Trade and the Culture of Clothing in the New Spanish Colonies (1600-1800)' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Dressing the New World. The Trade and the Culture of Clothing in the New Spanish Colonies (1600-1800).What effect did the successful marketing of European products have on the New World at the beginning of the 18th century? And how should one go about studying the European Fashion and Textiles that transformed the way people dressed in the Spanish colonies? “Dressing the New World” research project is framed by a unique document, which describes Mexico in 1700s.  This document is a rare reference for the knowledge of Spanish America at the beginning of the 18th century, and a very unique source to understand how and why Europe aimed to disseminate its textiles, commodities and fashionable goods overseas. The research project seeks to consider Early Modern Fashion in detail through this historical piece and other resources from literature, iconography and material culture, merging into different disciplines: Modern History, Art History and Dress History. Finally the research project aims to integrate the impact of politics and global connections in fashion studies for the early modern period. Official reports, political correspondence and accounts written by travellers are a rich source of information that allows us to write the history of fabrics and fashions and to study their impact, consumption and distribution in early modern times. Taken together these sources will offer a unique manner in which to envisage and articulate textiles and dress in the mix of cultures of the New World from the Spanish conquest in 1521 up to the 19th century, and map up how the global market connected different parts of the world in early modern time. Matched with a unique source of iconography (the “Casta paintings”), the achieved research will produce the first illustrated glossary on