RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Modeling the pharmacokinetics profiles of therapeutic peptides by chemoinformatics methods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Peptides have been acclaimed as the drugs of the future, thanks to their high specificity and activity, as well as their easy degradation. This implies that they generally possess reduced toxicity, few secondary effects, and are thus administered in small doses. Peptides possess multiple therapeutic applications, which include: antivirals, antifungals, antibiotics, modulators of the immune, cardiovascular and nervous systems, etc. However, it has been demonstrated that therapeutically relevant peptides generally exhibit limited capacity to diffuse across biomembranes such as the human gastrointestinal epithelium, in addition to their low stability. Moreover, due the short plasmatic half-life and low stability of these peptides, they are administered through injections, often several times a day. It is essential to develop methods for modeling the bioactivity of peptides, predict their pharmacokinetic profiles and ultimately allow for the design of novel peptide chains adapted to predetermined bioactivity profiles. Such modeling systems will allow for the design of peptides with favorable therapeutic efficacy, and above all, ensure their adequate bioavailability and (preferably oral) administration.Based on this background, the objectives of PeptiMOL are:•Define parameters (numerical molecular descriptors) for characterizing the structural, compositional and physicochemical properties of peptides and develop a user-friendly Java-based tool for their computation.  •Construct mathematical models to predict the PK properties of peptides using the state of the art statistical and machine learning techniques. •Implement the developed models in a Java-based chemoinformatic platform which will enable potential end-users to virtually screen peptide libraries or design novel pept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Improved therapies for soil-transmitted helminthiases: exploring pharmacomicrobiomics, novel drugs and microfluidic assay platforms'.

assistant: **Objectives**

An estimated 1.5 billion people are infected with soil-transmitted helminths (STHs) causing a global burden of 1.9 million disability-adjusted life years (DALYs). Current treatment options are limited. Preliminary studies in my lab hint towards a gut microbiome mechanism responsible for treatment failures of the most efficacious treatment currently available, albendazole-ivermectin. I propose an innovative 5-year project (“DRUGSBUGS”) that holds promise for major breakthroughs in anthelminthic drug discovery and development. I will deepen the understanding of current and potentially upcoming anthelminthics, in particular the microbiome-driven modulation of anthelminthic treatment. I will investigate underlying gut microbial structures in human stool samples associated with efficacy of albendazole-ivermectin treatment. Findings will be experimentally validated in vitro and in vivo. In addition, I speculate that emodepside will emerge as a novel key player in the anthelminthic drug armamentarium, which will enhance efficacy and reduce the risk of selection of resistant helminth populations. DRUGSBUGS proposes two Phase 2a dose selection trials with emodepside against Trichuris trichiura and hookworm in adults. Subsequent Phase 2b studies will assess whether emodepside is superior to albendazole against hookworm and T. trichiura. Using a microsampling technique, I will characterize the pharmacokinetics of emodepside in patients infected with T. trichiura and hookworm. In parallel, investing in innovative new technologies in the field of drug discovery will facilitate the discovery and development of the next generation of anthelminthics. I propose to study drug effects on motility and viability of different STH larvae applying electrical impedance spectroscopy on a microfl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interfacial electrochemical bacterial recognition' (INTERBAC) under Sixth Framework.

assistant: **Objectives**

The aim of this project is to investigate fundamental aspects of the physical chemistry of bacterial cell / substrate interactions. Well-defined surfaces of both single crystals and multi-layered gold deposits on quartz elements will be used to resolve the interfacial electrochemistry by capacitance measurements. The use of single crystal electrodes is essential in order to avoid the uncertainties of classical electrode surfaces that have a surface rugosity of the same order of magnitude as the dimensions o f the bacteria investigated. This will ensure a high degree of control and reproducibility of the electrode material. The potential dependence of bacterial attachment and biofilm formation on these surfaces will be studied by microgravimetry, infrared reflectance spectroscopy and ac impedance spectroscopy.The results will be used to develop an interfacial model of the potential distribution and therefore to calculate the interfacial capacitance of the cell membrane-interstitial solution- metal surface. Es cherichia coli cells will be used to exploit the metabolic change during the aerobic / anaerobic transition in order to determine the influence of metabolism on interfacial electrochemistry. Feeding with nutrients of different energetic yield will also be used to produce differential metabolic states. In addition, specific bacterial attachment to gold surfaces will be directed by surface modification with thiols containing a recognition termination. Live and dead cells will be used in the bacterial recognition experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stable Optimized Layered Inorganic/organic Devices' (SOLID).

assistant: **Concept**

The SOLID (Stable Optimized Layered Inorganic/organic Devices) project aims to advance Layered Metal Halides (LMHs) in photovoltaic technology, addressing the European Green Deal’s priorities for clean energy innovation. The project focuses on developing LMHs with polyaromatic organic ligands that enhance π-stacking interactions in a manner to increase charge mobility within the new materials, targeting power conversion efficiencies above 20%. Key objectives include synthesizing LMHs with at least a 10% increase in charge carrier mobility, optimizing thin-film deposition techniques for vertically oriented sub-lattices, identifying compositions with reduced trap states and optimal bandgaps, and achieving less than 10% degradation in performance after 1,000 hours under standard conditions. By overcoming stability and efficiency challenges in perovskite solar cells, SOLID will set new benchmarks for scalable, high-performance photovoltaic materials. The project will have broad scientific impacts, advancing knowledge in materials science and influencing future research and technology development. It will also contribute to societal goals by enhancing renewable energy adoption, reducing greenhouse gas emissions, and supporting the transition to a sustainable energy future. The project integrates environmental sustainability, including resource-efficient lab practices and the exploration of greener materials. Career development is central, with training in advanced characterization methods, sustainable research practices, and project management under the mentorship of experts at ICIQ. This experience will prepare the researcher to lead in renewable energy innovation, directly supporting the EU’s climate and sustainability targets.


**Keywords:** Layered Metal Halides, perovs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks' (NEWGENERIS) under Sixth Framework.

assistant: **Objectives**

NewGeneris will test the hypothesis that maternal exposure to dietary compounds with carcinogenic and iimunotoxic properties results in in utero exposure and molecular events in the unborn child leading to increased risk of cancer and imnune disorders in later childhood. B??rmarkers of exposure, carcinogenic and iimunotoxic risks and of susceptibility will be developed and applied using higfr throughput techniques. Existing European mother-child birth cohorts will be used while new biobanks will be set up in different European regions to generate specific information, and to collect uitoilical cord blood sanples. Training and educational activities will be carried out. New3eneris will address the following objectives:(1) Dietary exposure of pregnant wonnen to dietary carcinogens and iirmunotoxins will be assessed using available questionnaires fron existing mother/child birth cohorts.(2)Epidemiological surveys of mother/child birth cohorts will be used to study associations between maternal dietary exposure, and childhood cancer risk factors and imnune disorders(3) Paternal exposure to dietary toxins will be considered as an additional genetic risk.(4) An in vitro model of transplacental perfusion will be used to better understand in utero exposure to selected toxins.(5) In cord blood sanples from existing cohorts and newly initiated biobanks bianarkers will be used to assess fetal exposure to these compounds and compared with maternal exposure.(6) In the sane sanples, genetic pathways indicative of risks of cancer and immune disorders in later childhood will be studied by analysis of lynphocytic gene expression and protecmics profiles.(7) Liter-individual variability in responses will be evaluated by gene-typing of infants' ENA, and by phenotyping for ENA-repair activi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Time compression - a study of the leather making process to optimise production scheduling. minimising delays and bottlenecks and maximising through-put'.

assistant: **Concept**

Time has become a valuable resource. The world has changed radically in the last 10 years, new manufacturing nations have appeared, there is greater competition across national boundaries. The demand is for better products. Instead of becoming more homogeneous, the world market has fractured into a collection of individual niches which will absorb accelerated turnover. There are, therefore, more opportunities to develop and sell competitive products, but it will only be of benefit for those manufacturers who can respond fast enough. This applies equally to the European Tanning Industry as to the more obvious Hi-Tec industries. The Tanning Industry will only survive in these niche markets as long as it stays ahead of the competition. The objective of this project is to examine and implement the use of Time Compression techniques to improve factory processes, organization and design to essentially reduce through-put times and improve response times. The investigation will apply itself to all aspects of tannery operation. It will be possible at the end of the project to establish a common approach and framework for saving time", which any tannery can implement and help improve it's competitiveness."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Adaptive Security and Privacy'.

assistant: **Objectives**

With the prevalence of mobile computing devices and the increasing availability of pervasive services, ubiquitous computing (Ubicomp) is a reality for many people. This reality is generating opportunities for people to interact socially in new and richer ways, and to work more effectively in a variety of new environments. More generally, Ubicomp infrastructures – controlled by software – will determine users’ access to critical services.With these opportunities come higher risks of misuse by malicious agents. Therefore, the role and design of software for managing use and protecting against misuse is critical, and the engineering of software that is both functionally effective while safe guarding user assets from harm is a key challenge. Indeed the very nature of Ubicomp means that software must adapt to the changing needs of users and their environment, and, more critically, to the different threats to users’ security and privacy.ASAP proposes to radically re-conceptualise software engineering for Ubicomp in ways that are cognisant of the changing functional needs of users, of the changing threats to user assets, and of the changing relationships between them. We propose to deliver adaptive software capabilities for supporting users in managing their privacy requirements, and adaptive software capabilities to deliver secure software that underpin those requirements. A key novelty of our approach is its holistic treatment of security and human behaviour. To achieve this, it draws upon contributions from requirements engineering, security & privacy engineering, and human-computer interaction. Our aim is to contribute to software engineering that empowers and protects Ubicomp users. Underpinning our approach will be the development of representations of security and priva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovation in Tuberculosis' under Horizon 2020.

assistant: **Concept**

The objective of INNOVA4TB is to enhance and strengthen the collaborative research among sectors and to form a network aimed to perform high-quality and translational research in the field of diagnosis and management of tuberculosis (TB). The consortium is constituted by 12 institutions from 8 countries that combine complementary and synergic expertise: clinical management (hospitals), basic science and new technologies (academic institutions), and industrial development and entrepreneurship culture (SMEs). The exchanges between the institutions allow the participants to progress in their career perspectives.TB is one of the major infectious diseases worldwide, and the emergence and spread of drug resistant cases is a public health threat. However, the conventional methods used for diagnosis and drug-susceptibility testing are not enough for controlling the disease. In addition, all TB patients, independently of their age, gender, severity of the disease and type of responsible strain, follow the same treatment duration (up to 20 months in drug resistant cases), which often leads to high frequency of adverse events, suboptimal adherence to treatment, and poor outcome. A transition from programmatic to personalized management of TB is needed. Our proposal will develop innovative technologies and approaches in order to improve the individual risk assessment for TB development, to rapidly diagnose active TB, to detect the drug susceptibility of the strain, to design tailor-made therapies, and to use biomarkers to guide and individualize the duration of antimicrobial therapy. This is of great importance for improving the quality of life of patients and ensuring treatment success, as well as for economic reasons for the healthcare system.


**Keywords:** tuberculosis, diagno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fatherland as Motherland. Unstable Gender and Nation in Italian Great War Literature'.

assistant: **Concept**

'Fatherland as Motherland. Unstable Gender and Nation in Italian Great War Literature' is an interdisciplinary project exploring the interplay between nationalism and gender in Italian Great War literature. By tackling a diverse range of texts (pamphlets, prose fiction, memoirs, diaries, propagandistic publications), it will analyse gender patterns at work in Italian Great War literature and disclose their unstable relationship with nationalist ideology. WWI literature provides an extraordinary testing ground for exploring nationalist discourse in its ambivalences in that it absorbs its tenet, while reshaping it and releasing its instabilities. Such an approach proves highly needed: Italian WWI literature has been usually employed to describe the passage to the fascist period as if it were a homogeneous ideological set that could explain the rise of fascism. FatherMotherland will argue against both these premises (ideological stability of Italian WWI literature; its consistency with fascist culture) by means of an inquiry focusing on gender issues. The project will develop along three main lines: 1. The representation of manliness and virility; 2. The rhetorical features of the icon of the motherland; 3. The re-fashioning of the war literature canon in the fascist period. FatherMotherland has the ambition to foster a better understanding of the cultural roots of nationalism, which today threatens the process of European integration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Solid Oxide Cell and Stack Testing, Safety and Quality Assurance""' (SOCTESQA), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of the present project proposal is to develop uniform and industry wide test procedures for SOC cell/stack assembly. The proposal builds on experiences gained in the FCTESTNET, FCTESQA series of projects taking up the methodology developed there. This project proposal will address new application fields which are based on the operation of the SOFC cell/stack assembly in the fuel cell and in the electrolysis mode. The project partners have long-term experience in the development, testing and harmonization of solid oxide cells/stacks. The project will have a clear structure based on an initial definition phase, the development of generic test modules which will be validated by experimental validation phases. The review of the test procedures will result in modified test modules leading to a subsequent second validation loop. At the end of the project, the final test modules will be confirmed by round robin tests. Moreover, the project will address safety aspects, liaise with standardization organizations and establish contact with industrial practice. This collaborative project will essentially help to accelerate the development and the market penetration of hydrogen and fuel cell (H2&FC) energy systems in Europe.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ADAPTIVE OPTICAL METASURFACES FOR REAL-TIME, LABEL-FREE AND NON-DESTRUCTIVE 7D DIGITAL PATHOLOGY' (OPTIPATH), addressing dissemination and exploitation.

assistant: **Impact**

Treatment decisions for many pathological conditions, including inflammatory, degenerative, autoimmune, infectious diseases, and cancer, are largely based on microscopy study of the surgically excised tissue specimens (histology). OPTIPATH provides a new paradigm for gathering objective optical tissue-dependent data, which is essential to overcoming the diagnostic challenges of inter-observer variability and limited sensitivity and specificity. OPTIPATH will offer non-destructive, label-free, real-time, 3D-presentation of tissue samples. This is enabled by (i) revolutionary nano-photonic optical metasurfaces (OMS) for simultaneous single-shot acquisition of spectral and polarimetric information, and adaptive OMS actuated by thin-film piezoelectric Micro-Electro-Mechanical-Systems (MEMS) for (ii) rapid Vector Vortex Beam (VVB) shaping of light, and (iii) rapid confocal 3D imaging. The wealth of objective diagnostic data provided will be interpreted using Machine Learning (ML) / Deep Learning (DL), and is essential to overcome inter-observer variability in diagnosis and provide actionable insights to the clinician. By utilizing optical markers present in unprepared tissue histological procedures can be dramatically sped up, offering real-time diagnosis in operation theatres and pathology departments. By offering timely and accurate diagnosis, OPTIPATH will enable early diagnosis and improved prognosis of recovery.


**Keywords:** Histopathology, photonics, nonaphotonics, metasurfaces, MEMS