RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Study of specific cell mediated immunity and vaccine optimization against bacterial and viral infections in trout (Oncorhynchus mykiss)'.

assistant: **Concept**

Rainbow trout are one of the most valuable fish species farmed in the European Union, thus knowledge of its immune system is of practical importance. This project is focused on the study of interleukin 2 (IL2), a central cytokine in the regulation of T-cell responses, which stimulates proliferation of these cells and increases cytotoxicity of CD8+ T cells, natural killer, B cells, monocyte/macrophages and neutrophils. IL2 is an important adjuvant for inactivated or subunit viral vaccines in humans and may have a potential role in protection against bacterial and viral diseases.  Initially expression studies of IL2 in head-kidney and spleen will be examined by PCR, after administration of different immunostimulants, since this molecule is not constitutively expressed. Next, the activity of the recombinant protein (rIL2) will be established. An antibody to IL2 will also be generated for subsequent use in ELISPOT assays. Thus the specific cell-mediated immune response in trout will be quantified by enumerating the number of cells secreting IL2 in response to antigen, establishing a relationship between the size of the IL2 response and protection post-vaccination using a model bacterial, Aeromonas salmonicida, and viral,  haermorrhagic septicaemia virus, VHSV, pathogen.  Further experiments will be carried out using the rIL2 to increase the effectiveness of fish vaccines by inclusion in the vaccine. Following vaccination, the A. salmonicida and VHSV antibody titres will be determined for the serum and correlations sought between the size of the antibody response, the IL2 secreting cell response and resistance. Finally, IL2 secreting cells will be induced and identified using the monoclonal antibodies to detect intracellular IL2 and sorted by FACS. The sorted cells will be c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Automatic system to reduce roll-over in heavy goods vehicles' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The innovative idea is to use weight sensors embedded in a truck axle, one at each end, to measure the loading on each wheel. Using the information from the sensor outputs the degree of stability of the moving vehicle can be assessed. This stability can be measured in terms of load transfer from wheel to wheel at opposite ends of the same axle. The output from the two sensors can be compared electronically to give one voltage signal representing the instability and 'roll potential' of the vehicle. Also, as the load transfer that occurs during the journey can be constantly monitored in this way, it can provide a direct measurement of the instability/roll potential of the vehicle, and it could give an ideal electronic signal to provide automatic adjustments to the vehicle, of which speed control is likely to be most effective. Speed control and suspension adjustments are to be researched in this project to achieve control over stability and roll occurrence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Tackling the paradox of growth and sustainability - A SDG indicator framework for water, energy, land, and materials based on postgrowth and resource nexus thinking' under Horizon Europe.

assistant: **Concept**

The United Nations' Sustainable Development Goals (SDGs) suggest a useful framework; however, they lack well-defined indicators, failing to account for resource interlinkages. Resource nexus thinking has gained traction recently since it targets synergies and helps avoid competition of resources. Additionally, decoupling economic growth from emissions and resource use has been sought after, and attempted through 'sustainable growth' and 'green growth' within the SDGs. This is a paradox since growth and climate mitigation are not compatible; growth has significant environmental and social costs. Consequently, critics of green growth (and subsequently the SDGs) are gravitating towards degrowth (which is not mentioned in the SDGs), whose goal is to reduce economic activity, reaching a level that is ecologically sustainable. Although degrowth has the virtue of recognising the concrete limits of global growth, it is still under development and has faced criticism, since it rarely presents implementable actions, with most research concentrating on conceptual essays. This project will integrate the postgrowth and resource nexus literatures to construct an analytical framework of indicators, to improve on existing SDG indicators (regarding water, energy, land, and materials), in a move away from green growth and decoupling principles, and towards principles of equity and sufficiency. The framework will consist of critical indicators accounting for embodied resource use to help towards an equitable downscaling of resource throughput. The extent of North and Souths unequal exchange will be quantified, critical resources and degrowth potential for different countries will be identified, while the limits to growth will be tested. Finally, this project will inform a meaningful discu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Title: Self-Renewal, Fate Potential and Plasticity of Human Embryonic and Induced Pluripotent Stem Cell-Derived Neural Stem cells', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Neural stem cells (NSCs) can propagate in vitro while retaining ability to differentiate into neurons, astrocytes and oligodendrocytes. However, because of the nature of their developmental progression, NSCs isolated at different developmental stages or regions exhibit remarkable differences in their ability to yield specific neuron types. Specifically, NSCs grown in vitro rapidly lose access to the full neuronal spectrum. Limited NSC potential is one of the major impediments for applications in regenerative medicine, specifically for Parkinson’s and motoneuron-related diseases. Therefore, there is an enormous need to understand how NSCs self-renew.Human embryonic stem cells (hESCs) are known to provide access to early neural fates. We have recently isolated a novel type of early NSCs derived from hESCs termed rosette-NSCs (R-NSCs), which respond to such regional patterning cues. We proved the unique NSC stage of R-NSCs based on their cytoarchitecture, marker expression, stem cell properties and differentiation potential. Nevertheless, we only partially identified growth requirements and signaling pathways governing the R-NSCs stage.Here we would like to address these limitations by defining heterogeneity within R-NSCs and develop genetic strategies to prospectively isolate fully patternable R-NSCs. Generating transgenic hESC reporter lines will serve as reliable readout for defining R-NSC stage, identity and function, and will be used for establishing correlative genome-wide chromatin state and promoter methylation maps. Finally we will systematically probe function of extrinsic/intrinsic factors affecting R-NSC identity, neural patterning potential and epigenetic state. This should provide fundamental insights into the genetic/epigenetic mechanisms of neural patternin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'mTOR pathophysiology in rare human diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The mammalian Target Of Rapamycin (mTOR) is a master regulator of growth. mTOR is a protein kinase that exists in two distinct complexes in the cell and transduces virtually all anabolic signals from the environment: nutrients, such as glucose and amino acids, growth factor peptides, such as insulin and insulin like growth factors, oxygen, mitochondrial metabolites, energy status. mTOR is required to sustain cell responses to nutrient availability including cell growth, proliferation, macromolecule biosynthesis, and suppress autophagy. During the past ten years we have generated and characterized a wide panel of mouse mutants in the mTOR pathway. We were involved in revealing specific phenotypes that increased our knowledge of mTOR roles in pathophysiology: mutants with small cells, mutants resistant to tumorigenesis in specific tissues and after specific oncogenic insults, mutants mimicking caloric restriction and promoting longevity, mutants with muscle dystrophy, mutants with altered insulin action.The overall goal of our research proposal for the next five years is twofold. From one hand we want to better understand fundamental processes including cell size control and organismal longevity. To this end we want to determine the molecular targets of the mTORC1/S6 kinase cassette that may explain the alterations in cell size and lifespan when these kinases are deregulated (project 1). From the other hand we want to understand and cure rare human genetic diseases that arise from pathological changes in the activity of the mTOR pathway in children or that may benefit from therapeutical intervention on this pathway. These diseases include Tuberous Sclerosis Complex, PEComas and hemangiomas (project 2), metabolic diseases (projects 3), lysosomal storage diseases (project 4
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for ''On the fly' direct dynamics studies of photochemical reactivity development of derivative mc-scf' (1994-1998).

assistant: **Innovation**

Research objectives and content The research programme involves development of a fully direct derivative MC-SCF programme and applications to organic photochemistry. a) Development: In direct MC-SCF theory AO integrals are computed directly during the solution of the MC-SCF equations. Such techniques are essential if MC-SCF methods are to applied to real problems in organic reactivity because one can avoid the need lo store integrals on slow external disk storage. Further, the size of computation that can be run depends only on the amount of computer time available rather than the disk capacity of the computer. Our major objective is to implement the same type of algorithm for derivative MC-SCF. b) Applications Modern time-resolved spectroscopic measurements are now being used to probe the intimate mechanistic details of some small molecule organic photochemical reactivity problems. The initial focus of our work will be the complementary theoretical work. The experimental experience provide details of very short lived intermediates and even transition states, quantities such as rate may be strongly influenced by dynamics associated the evolution of the excited states itself. The theoretical work may suggest new experiments or the re-interpretation of older ones. Recently the photochemical decabonylation of cyclopentanone to produce tertramethylene diradicals has been studied on the femptosecond timescale. However. the mechanism of the decarbonylation is completely unknown. We are in a unique position to probe the details of the dynamics on the excited state and the subsequent evolution of ground state products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sourcing Hydrogen for Alternative Mobility, Realising Opportunities and Creating Know How in Ireland' (SH2AMROCK).

assistant: **Innovation**

SH2AMROCK - Ireland's Emerald Hydrogen ValleySH2AMROCK will deploy green hydrogen across key hard-to-abate sectors across the island of Ireland – including key infrastructure to enable the production, distribution, and use of green hydrogen. The 5 year-project, with a total investment of approximately €80m, will showcase the capacity of H2 to maximise penetration of RES through sector coupling, while facilitating widespread integration of renewable H2 into Ireland’s energy system. SH2AMROCK will realise this goal through the deployment of the country’s first hydrogen valley and multi-modal H2 transport hub in Galway – accelerating the island of Ireland’s energy transition and decarbonisation across multiple end-user applications.


**Keywords:** Hydrogen, Hydrogen Valley
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'COncurrent METAmaterial-Structure design using functionally graded metamaterials'.

assistant: **Objectives**

The purpose of CoMetaS is to establish a network of interdisciplinary research groups to solve a new scientific and technological challenge of high practical interest for industry, consisting in developing an integrated, reliable and efficient multiscale methodology for Concurrent Metamaterial-Structure Design employing functionally graded mechanical metamaterials.Taking advantage of the unique technological opportunity that the design freedom revolution of 3D-printing at microscales is bringing to industry and engineering, the purpose of CoMetaS is to help the European industry and future academic system by generating the needed interdisciplinary and intersectoral network of researchers and engineers capable of developing high-tech, value-added products to increase its technological leadership, critical for high living standards in a global market. CoMetaS constitutes a multidisciplinary change of paradigm on how engineering structural design has been performed to date, integrating the metamaterial design concurrently with the structural design through double inverse analyses and surrogate continuum models obtained by data-driven techniques.CoMetaS is a highly multidisciplinary and intersectoral project, involving high-tech companies leading their fields and complementary leading academic research groups. CoMetaS has the right combination of excellence in research, academic training, and industry experience, and high international and intersectoral mobility for fostering innovation-oriented, entrepreneurial, and creative researchers. Through clearly defined research objectives, CoMetaS promotes high mobility, intersectoral, and transnational cooperation for excellent training, science and technology, by involving 6 academic research groups and 4 technological companies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Talent and Learning in Imperfect Markets' (TLIM) under Seventh Framework.

assistant: **Objectives**

The overall effectiveness at which the underlying talent resources in an economy are utilized is an important determinant of long-run economic growth and well-being. Recent work has shown that the processes through which talent is discovered and revealed in the economy are likely to suffer from market imperfections that are analogous to problems that have been for long been understood in the context of private provision of job training and education, resulting in not just reduced economic efficiency but also contributing to income inequality. The first basic question is what is the role of talent rents in explaining income inequality? In a static world where all information about talent is known, such talent rents would merely be compensation to a scarce factor of production. However, when the discovery of talent is subject to market imperfections then income differences that ostensibly look like talent rents are partly due to inefficient information rents. This raises the second and novel question, about whether and to what extent observed income differences are due to inefficient rents to information about talent that masquerade as talent rents. I also plan to investigate how technological change has impacted the distribution of talent rents via its effect on the discovery/revelation process of talent. The larger goal of the project is to help understand the economy-wide implications of institutions and policies that govern the discovery and allocation of talent in the economy. Better understanding could also point the way towards improved policy interventions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Community, identity and diversity in German youth radio' (CIDoRa) under Horizon Europe.

assistant: **Objectives**

In times of increased mobility, urbanisation and sociocultural tensions, the way professional media as information providers and public watchdog present diversity has implications for social cohesion and for how young people perceive identity and society. Against this background, youth radio stations, which have become increasingly interactive and collaborative in the digital age, are an important point of orientation for many young people living in ethnically and linguistically diverse spaces, often struggling to fit in, and looking for reliable information and guidance. Despite German broadcasters' statutory and moral obligations to promote social cohesion and to contribute to building a non-discriminatory society in Germany, the media's representations of ethnic diversity have frequently been criticised. Little is known, however, about what a meaningful engagement with diversity means for journalists and how they try to create social cohesion through their work. Through linguistic ethnography at a German youth radio station and a critical discourse analysis of media messages, CIDoRa will provide new insights into the linguistic and semiotic practices of radio content production to explore how journalists construct and negotiate a collective urban youth identity with their diverse audience and thereby try to create a sense of community. In this context, my project will shed light on possible issues that can lead to an unbalanced and negative portrayal of ethnic and linguistic diversity on youth radio to foster a more meaningful engagement of journalists with diversity. By developing approaches for diversity-oriented communication, CIDoRa responds to timely social concerns around difference and voice in a mobile world fraught with deepening division. The results of my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'modelling of integrated water systems under uncertainty for aquatic environment rehabilitation in rapidly urbanised catchments' (AMWRUC) targeting Seventh Framework.

assistant: **Abstract**

Many catchments in developing countries are undergoing rapid urbanization, in which water systems become a fusion of natural water bodies, rivers, and man-made water networks. It has also been widely recognized that rehabilitation of the aquatic environment is essential in maintaining the system's ecological and hydrological balance, especially under rapid urbanisation. There have been a number of EU projects, e.g. NeWater and AquaStress, on adaptive and integrated modelling of catchments, but very few have investigated adaptive measures necessary for rapidly developing countries. Modeling of these water systems poses a significant challenge and requires a change in thought paradigm in order to deal with rapid spatial-temporal changes in the physical elements and the associated catchment responses. Two case studies from Southern China, Maozhou river catchment and Shenzhen river catchment, would be carried out to demonstrate the reliability and effectiveness of the approach. The two catchments are both located in rapidly urbanised area of China but have different urbanisation level. Aquatic environments in the two catchments have been severely damaged due to tempestuous disturbances of human activities. The adaptive modelling approach would be applied to support decision making for aquatic environment rehabilitation in the catchments.  The objective of the project is to develop a novel framework of adaptive approach to model the integrated water systems, which is subjected to rapid changes over a relatively short period of time, effectively. It is envisaged that within the proposal framework, various simulation models, optimisation techniques and uncertainty analysis methods are integrated on a common platform to build up the fully integrated model of water system. This