RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Regioselective Hydrogen Bonding Phase Transfer Catalysis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The challenge of performing reactions with catalyst control over regioselectivity has not been met with a general solution. Here, we approach this longstanding problem in the field by addressing the specific question of how to regioselectively install fluorine - a key element in the agrochemical and pharmaceutical industries. By combining the charge-modulating properties of hydrogen bond donors with a phase transfer event, we propose that it will be possible to use simple fluoride salts in regioselective fluorination reactions. Using hydrogen bonding as an activation mode for cheap inorganic salts, we will address new challenges in site selectivity through catalyst design and an extensive interrogation of the potential energy landscape of the reactions. This research will demand catalysts that can control the charge density on a nucleophile and will require computational studies that enable the prediction of regioselectivity on the basis of a nucleophilicity index. To apply the lessons of these studies in the context of asymmetric catalysis, new high performance catalysts will be developed that are capable of kinetic resolution and enantioconvergent allylic fluorination. The ultimate test of the regioselective fluorination methods will be in the synthesis of novel PET tracers, where both time and operational simplicity are critical to achieving a high specific activity. Regioselective hydrogen bonding phase transfer catalysis will strongly influence the broader landscape of catalysis and yield mechanistic insight into a novel synthetic process while providing valuable biological probes from abundant feedstock chemicals. The interdisciplinary aim of this proposal is to connect computational chemists, synthetic organic chemists, radiochemists, and PET imaging specialists
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Sustainable production, processing and modelling of durable additive manufactured materials for enhanced performance and long-term service in complex environments.'.

assistant: **Objectives**

The current industrial approach to create metal products is unsustainable. Massive amounts of energy consumption, chemicals, water and the exhaustion of natural metal resources are the hallmark of metal production and processing industries. Metal Additive Manufacturing (AM) presents an opportunity to ameliorate metal processing and product manufacturing. While this is a known fact, a full scale industrial implementation of metal AM has been impossible until now due to the lack of consistent AM metal quality.DurAMat is the game-changer that will engender long-lasting performance properties of AM products used in severe exposure environments. DurAMat research will i) develop AM components from different alloy families sustainably ii) enable AM as preferred repair method for defunct metallic products and iii) enable AM for metal functionalisation. DurAMats research combines experimental research with multiscale modelling and machine learning (ML) methods.DurAMat fills important knowledge gaps and will innovate AM metals (duplex steel alloys for marine, magnesium for bioresorbable implants) and coatings (biocomposite and AM metal coatings for corrosion and mechanical performance), technologies and services (AM for repair, ML for corrosion inhibitor selection), three computational models (multiscale and ML) and one device (add-on for Wire Arc Additive Manufacturing microstructure control).The DurAMat consortium consists of 6 Universities, 2 Research Centres and 5 Industrial Companies from 6 European Countries. It will train 10 doctoral candidates in a holistic approach, encompassing cross-disciplinary scientific knowledge transfer, teaching activities and cultivating interpersonal and transferable skills.DurAMats impact forecasts, among others, a 30% energy reduction in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Wild Rice Culture and Indigenous Food Sovereignty in North America' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The 370 million indigenous people in the world make up 5% of the total population, yet they constitute one third of the 900 million extremely poor rural people. Indigenous women are affected disproportionately by these hardships as they struggle to provide healthy food for their families. Indigenous peoples’ traditional food is a critical, yet deeply compromised, dimension of their culture, health and well-being. In Europe and around the world, food sovereignty is being embraced by scientists, social movements and some governments as a framework that can be used to realise more sustainable and just food systems. Food sovereignty, in the indigenous North American context, involves a re-connection to traditional land-based food and political systems. While an emergent body of research has begun to chart out indigenous food sovereignty, this is an embryonic field. This fellowship will focus on the hitherto under-examined gendered dynamics of access to natural resources in indigenous food sovereignty. Dr. Jessica Milgroom will analyse how the indigenous-led revitalisation of wild rice, a culturally important food for the Ojibwe people of the Upper Great Lakes area of the United States, has become an important strategy to assert control of natural resources and work towards food sovereignty. Using a feminist political ecology perspective, the project will explore the historical and current patterns of control of access to wild rice by Ojibwe people. The project will be hosted by the largest centre in the world focusing on food sovereignty and will be co-produced with indigenous communities using an innovative, transdisciplinary research approach that combines western and indigenous research methods. Dr. Milgroom will expand her experience in transdisciplinarity, her expertis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Epigenomics and chromosome architecture one cell at a time' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In Eukaryotes, cellular identity and tissue-specific functions are linked to the epigenetic landscape and the multi-scale architecture of the genome. The packing of DNA into nucleosomes at the ~100 bp scale and the organization of whole chromosomes into functional territories within the nucleus are well documented. At an intermediate scale, chromosomes are organised in megabase to sub-megabase structures called Topologically Associating Domains (TADs). Critically, TADs are highly correlated to patterns of epigenetic marks determining the transcriptional state of the genes they encompass. Until now, the lack of efficient technologies to map chromosome architecture and epigenetic marks at the single-cell level have limited our understanding of the molecular actors and mechanisms implicated in the establishment and maintenance of the multi-scale architecture of chromosomes and epigenetic states, and the interplay between this architecture and other nuclear functions such as transcription.The overall aim of EpiScope is to unveil the functional, multi-scale, 3D architecture of chromatin at the single-cell level while preserving cellular context, with a toolbox of groundbreaking high-performance microscopies (Hi-M). Hi-M will use unique combinations of multi-focus and single-molecule localization microscopies with novel DNA labeling methods and microfluidics. Hi-M will enable the study of structure-function relationships within TADs of different chromatin types and correlate single-cell variations in epigenomic patterns to 3D conformations with genomic specificity and at the nanoscale. Finally, Hi-M will be used to develop a novel high-throughput, high-content method to unveil the full pairwise distance distribution between thousands of genomic loci at the single cell level a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plasma Enhanced Chemical Vapor DepositIon of Hard Coating on Optical Polymers' (PLASCOAT).

assistant: **Concept**

This project, supported by 4 SMEs involved in the production of components and plastic optical systems (mainly for ophthalmic) one from France, two from Italy and one from Finland, is aimed to design, realise and set up a process and a prototype plant using PE CVD (Plasma Enhanced Chemical Vapor Deposition) for the deposition of hardening, matching and hydrophobic coatings of substrates made of CR39 or polycarbonates. This novel process is aiming to replace the lacquering processes presently in use which may become objectionable on environmental grounds and to manufacture at a lower cost (at least 30% cheaper, thanks to a faster process) and better reproducibility ophthalmic lenses with better durability, performances (by example, by double the lifetime of the lenses) and multifonctionality than the ones available on the market place. The project is characterised by a strong cooperation among the SME's Partners and the research centres (CE.TE.V. supported by Biophy and University of Catanià) which, during the life time of the project, will continuously evaluate the compatibility of the new treatment PE CVD with their own optical antireflection, hydrophobic or solar treatments realised with the widely used lon Assisted Deposition and Sputtering processes. CeTeV will supply the Partners with hardened samples, treated on existing research plant, for comparison with the existing techniques ( lacquering as hardening and thermal evaporation for the hydrophobic layer) and for the evaluation of the compatibility with the deposition processes of the subsequent antireflection coatings effective in production. By the same time, the process and plant specifications (from technical and economical point of view) will be defined. In a second phase, the design and realization of a prot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Memory research: Ground-breaking, Applied, and Technological Exchanges'.

assistant: **Innovation**

In M-GATE, ESRs will combine state-of-the art experimental neurophysiology, innovative technologies, and advanced theoretical approaches to unveil memory mechanisms, from single neurons to brain networks, to cognition and behaviour, addressing the healthy and diseased brain. Through research and training from top-class scientists and close interaction with industrial partners, ESRs will develop unique multi-disciplinary skills combining physiology, molecularbiology, computation, micro-engineering, and entrepreneurshipThe exploration of the hippocampal formation and its role in memory is one of the great success stories of neuroscience. For no other structure have neuroscientists achieved such an in-depth knowledge of structure and mechanisms, making this field one of the most promising for breakthroughs in understanding human cognition. Our program will include world-leading, Europe- and US-based scientists in academic institutions as well as pharmaceutical, neurotechnological and machine learning companies, with the task of developing new technologies to understand memory and advance our chances to cure brain pathologies.Early-stage researchers will participate in scientific programs spanning hippocampus research broadly, from local circuital interactions at one brain site, to global networks including multiple brain structures. Dedicated projects will look at brain pathologies as epilepsy and Alzheimer’s from the circuits point of view. A neurotechnology work package spanning multiple projects will include novel methodological developments, bringing together academic and private sector technologists. With the help of targeted secondments and a tailored training program, we provide a unique opportunity for talentedresearchers to prepare for a career in either academic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Cloud In-Memory Database Appliance with Predictable Performance for Critical Applications' under Horizon 2020.

assistant: **Concept**

The project aims at producing a European Cloud Database Appliance for providing a Database as a Service able to match the predictable performance, robustness and trustworthiness of on premise architectures such as those based on mainframes. The project will evolve cloud architectures to enable the increase of the uptake of cloud technology by providing the robustness, trustworthiness, and performance required for applications currently considered too critical to be deployed on existing clouds.CloudDBAppliance will deliver a cloud database appliance featuring:1.    A scalable operational database able to process high update workloads such as the ones processed by banks or telcos, combined with a fast analytical engine able to answer analytical queries in an online manner. 2.    A Hadoop data lake integrated with the operational database to cover the needs from companies on big data.3.    A cloud hardware appliance leveraging the next generation of hardware to be produced by Bull, the main European hardware provider. This hardware is a scale-up hardware similar to the one of mainframes but with a more modern architecture. Both the operational database and the in-memory analytics engine will be optimized to fully exploit this hardware and deliver predictable performance. Additionally, CloudDBAppliance will deal with the need to tolerate catastrophic cloud data centres failures (e.g. a fire or natural disaster) providing data redundancy across cloud data centres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Organelle-to-Organelle Crosstalk in Mast Cells: How does Endoplasmic Reticulum Secretory Granule Interaction impact the MC's Immune Responses?'.

assistant: **Innovation**

Mast cells (MCs) are tissue resident immune cells best known for their role in allergy. However, as part of the adaptive and innate immune system they engage in various pathologies including cancer and neurodegeneration. When MCs exert their immune response, special lysosome-related organelles, called secretory granules (SG), in which protective and proinflammatory mediators are prestored, undergo exocytosis. The recent discovery that during this process also mitochondrial and endoplasmic reticulum (ER) proteins are secreted, suggests that SGs may have, in addition to their extracellular immune, an intracellular metabolic function, such as in mito- or ER-phagy. In preliminary work using ultra expansion microscopy (uExM) we indeed found that the ER-phagy receptor SEC62 also localizes to the SG lumen. Strikingly, we further discovered that the exocytosis of SGs is accompanied by drastic ER-remodelling, particularly peripheral ER-sheet formation.However, the biological purpose as well as the underlying mechanism of this process and whether ER-phagy may be involved is currently unclear. Further, it remains to be elucidated which of the three ER-phagic pathways (macro-, micro-ER-phagy, LC3-dependent vesicular transport) connects to the SGs and whether the fate of the resulting vesicle represents a way of unconventional protein secretion.Due to the size of ER membranes, the sub-vesicular/ER-phagic structures and the densely filled MC cytoplasm, the investigation of the assembly and evolution of SG-ER contacts demands a look beyond the diffraction limit of light. Therefore, I will employ different super-resolution methods such as uExM and live cell Stimulated Emission Depletion (STED) microscopy in combination with automated image analysis, to answer these questions.This work
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Identification of physical models of the piano instrument and its application to sound synthesis by simulation'.

assistant: **Objectives**

Research objectives and content Our research project copes with the physical modelling of the piano instrument through the eyes of system identification: Given a consistent parametric model structure of the piano dynamics, relevant parameter values are estimated by minimising the deviation between true piano acoustic recordings and the corresponding model response. Although the modal analysis of the vibrations of a single piano string is elementary, the modelling of the piano sound is intricate because of complex acoustic-mechanical coupling effects (see e.g. N. Fletcher et al., The physics of musical instruments, Springer-Verlag, New-York, 1991). Here, the string dynamics is a distributed system with two inputs and one output. The inputs are the hammer excitation and the bridge force at one of the string ends. The system output is the movement of the string at the bridge side. String vibrations occur when feeding back the system output at the second system input. A large effort will be devoted to carefully detail this feedback dynamics, i.e. coupling between the (in unison) strings and the bridge reaction. The hammer dynamics has a fundamental impact on the time-frequency properties of the piano tone so that a detailed mechanical modelling of the hammer action is needed. As a result, the physical model of the hammer-soundboard dynamics consists in a parametrised model structure whose l parameter are to be estimated on the basis of elementary piano tone records. Training content (objective, benefit and expected impact) The objectives and the benefits of the training consist in the physical modelling of mechanical systems, in the acoustic and | identification expertises as well as in the use of acoustically-oriented computer materials. The training impacts rely on the |
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New approaches to mapping the signs of violence and care in the migratory landscapes of silenced women'.

assistant: **Innovation**

Currently, migration is posing a global challenge for the formation of societies and States, being a key factor of the feminisation of the phenomenon. When the migration process is undertaken under situations of vulnerability, it can be linked to structures that generate violence, exploitation, disappearance, and/or human trafficking. The routes that go from Central America to the USA by land present examples of these structures. The SIGNAL-LANDSCAPE project aims to: 1) Build a creative and transnational cartography that reflects the points of damage, as well as the care and resistance of the migratory route. 2) Design methods and tools that facilitate the processes of construction of the life story while avoiding re-victimisation. 3) Breaking the silencing to which the stories of migrant women are subjected, thus generating narrative results. 4) Produce academic knowledge, that will reach certain spaces for the design of policies and social networks.The Researcher will carry out a multi-sited ethnography: origin (Honduras), the route (Mexico-Guatemala), and destination (USA). In these spaces, she will work with women, through local organisations, to build creative narratives that will allow the designing of: 1) the physical landscapes that reflect the damage and care that women have experienced along the route; and 2) the geographical and social landscapes of their experiences. The researcher has doctoral experience with Nigerian migrant women, who are often linked to human trafficking, and she has developed a methodology proposal to take into account the silencing. Furthermore, the trajectory of both supervisors in the field, the Host Centres, and the support of the two Chairs:  1) UNESCO-Gender, Wellbeing and Culture of Peace, University of Wisconsin-Madison, USA and