RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Uncovering the function of novel cytoskeletal polymers in the extreme mechanics of eukaryotic cells' (XtrmCells) under Horizon Europe.

assistant: **Objectives**

The ability of eukaryotic cells to generate and resist mechanical forces, locomote and spatially organize their subcellular structures relies on the cytoskeleton. The hallmark of cytoskeletal proteins is their ability to polymerize into filaments, which in turn organize into cellular-scale networks that support a variety of functions that require the generation of mechanical force. Decades of work have significantly increased our knowledge of the composition and mechanisms of force generation by networks of actin, tubulin and intermediate filaments. In contrast, the mechanisms and function of cytoskeletal networks, whose primary component is centrin remain unexplored. Centrins are conserved proteins across all eukaryotes that localize  ubiquitously to microtubule organizing centers. In unicellular eukaryotes, centrins form filaments and networks that support the extreme morphodynamics required for the behavioral responses of these free living organisms. By combining approaches from cell biology and biophysics we will establish the function of centrin as a cytoskeletal polymer and uncover the mechanisms by which it assembles into large-scale structures capable of force generation in ultrafast timescales. Our studies will establish novel mechanisms by which cytoskeletal networks generate, transmit and respond to mechanical signals. Beyond their biological significance, our findings will provide blueprints for the design of novel bio-inspired materials capable of withstanding large strains and undergoing extreme elastic deformations.


**Keywords:** cytoskeleton, centrin, cell mechanics, cell material properties, behavior
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular analysis of g-protein coupled receptor kinases following manipulations of serotonergic and noradrenergic transmissions in the rat central nervous system' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Receptor desensitization is at the origin nf the progressive reduction of efficacy of some drug treatment. Adrenergic (beta2 and alpha2), muscarinic cholinergic, serotonergic (5-HT4) and many other G-protein coupled receptors (GR) are rapidly desensitized when stimulated by an agonist. G-protein coupled receptor kinases (GRK) and beta-arrestins are two families of proteins that are responsible for this process. Despite a better understanding of the molecular mechanisms involving GRK/beta-arrestins little attention has been paid to the functional roles of these latter proteins. The aim of our project is to investigates in some rat brain regions, the adaptative changes in GRK/beta-arrestins expression (mRNA and proteins) and activity followlng repeated antidepressant treatment (noradrenergic and serotonergic uptake inhibitor) or specific neural lesion (with 5,7-DHT or DSP-4 neurotoxins). In situ hybridization; Northern blot, rhodopsin phosphorylation assay and quantitative autoradiogaphy shall be used. GRK/,beta-arrestins-induced desensitization could become a new pharmacological targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Integrated assessment tools to gauge local functional status within freshwater ecosystems'.

assistant: **Objectives**

Problems to be solved Biological monitoring of river ecosystems within Europe is based almost entirely on measures of community structure and ignores functional aspects of the systems being studied. However, rivers are managed in order to maintain essential 'ecosystem services', which are dependent on the functional integrity of the system. It is surprising, that complementary measures for assessing ecosystem function have yet to be developed. This project aims to redress the balance by developing an integrated set of tools that can be used to aid management-decision making by supplying information on the state of ecological processes that maintain key ecosystem services, and by providing a reference database that can be used to inform the setting of ecological quality targets. Scientific objectives and approach Tools development will reflect species functionally representative of the 3 ecoregions studied (in Portugal, The Netherlands and the UK). Two types of bioassay will be employed:(i) measures of energy supply (i.e. primary production, detritus processing);(ii) measures of energy consumption and transfer (i.e. algal (periphyton and phytoplankton) grazing and detritivore (shredder and collector) feeding). Methods will be adapted for in site deployment. Individual-based models (e.g. dynamic energy budget models) will be used to project the consequences of short-term changes in feeding rate measured in site bioassays for individual vital rates. Two types of model systems, representing high flow conditions, and low-flow conditions, will be used to validate in site tools. Two training courses will be organised, so that all partners can be instructed in the application of the developed tools. The tools will initially be tested in the absence of contaminants. Four referen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Local Dimensions of a Wider European Neighbourhood:Developing Political Community through Practices and Discourses of Cross-Border Co-operation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

With the concept generally known as Wider Europe", the European Union has mapped out an ambitious vision of regional "Neighbourhood" that "goes beyond co-operation to involve a significant measure of integration". Furthermore, the EU sees this new quality of regional interaction and partnership as bringing "enormous gains to all involved in terms of increased stability, security and well being".EUDIMENSIONS seeks to understand the implications of these emerging geopolitical contexts for cross-border co-operation and political relationships at the local level. More specifically, we will scrutinise the development of a "Wider European" political community as manifested by co-operation initiatives and changing political discourses that relate communities and groups to each other across national and EU borders.EUDIMENSIONS will perform this task by analysing co-operation processes and the multilevel contexts within which they operate. Case studies will focus both on specific communities and cross-border co-operation networks that often transcend local, regional and national levels in order to advance their agendas. In addition, we will also focus on civil society and gender-specific issues, aspects that require greater attention in studies of cross-border co-operation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploring the moderating role of x-efficiency on marketing strategy, business capabilities & organisatinal performance.' (1994-1998).

assistant: **Innovation**

Research objectives and content sustainable management of water resources in European countries, both for water quantity and water quality, in response to climate change. The development of these techniques depends on improved understanding of the hydrological effects of climate change, and the relationship between hydrology and land use. The project draws upon the results of two long-running studies, the UK Institute of Hydrology's Plynlimon catchment experiment and the studies of the environmental problems of Lake Balaton carried out by the Water Resources Research Institute (Vituki) based in Budapest. Hydrometric records from catchments in mid-Wales and Hungary, representing the wet uplands of the western seaboard and the drought-prone continental region respectively, will be examined for trends and changes that can be attributed to climate, either to long-term change or to natural cyclic fluctuations, and the data will be used to establish relationships between climate and hydrology. Particular attention will be given to the prediction of surface water quality changes. The models linking climate and hydrology will be incorporated into a decision support modelling system, which will draw on experience with geographical information systems (GIS) and catchment models ranging from steady-state and seasonal models to intermediate-complexity event-based models. The project will undertake the identification of important issues of water and environmental management in relation to climate changes and the anthropogenic context, and a detailed examination of proposed control strategies will be carried out for the two pilot areas. Finally a closing workshop will consider the application of the techniques developed for this project to other areas of Europe, with particular atten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards controlling antimicrobial use and resistance in low-income countries-an intervention study in latinamerica' (ANTRES), addressing dissemination and exploitation.

assistant: **Impact**

Irrational use and bacterial resistance to antimicrobials are major public health problems amplified in low- income countries. The project will describe antimicrobial use and resistance in healthy children in urban and remote rural communities of Bolivia and Peru. Antimicrobial use will be analysed by means of household surveys with a triangulation of methods. Antimicrobial resistance will be analysed in commensal flora using a robust resistance screening method. Resistant bacteria will be investigated for genetic resistance mechanisms. Influencing factors including policy and non-human use will also be analysed. To improve the situation a community intervention package focusing on rational use of antimicrobials will be evaluated. It will be developed and implemented in collaboration with the local public and private health services on the basis of the generated results enforced by the national drug policy. The project will contribute to a more appropriate antimicrobial use and evidence based antimicrobial policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DECIPHERING THE ROLE OF TRIB1 IN REGULATORY T CELLS' to be submitted under Horizon 2020.

assistant: **Abstract**

The role of regulatory T cells (Tregs) is crucial to maintain immune homeostasis by controlling peripheral tolerance. A better understanding in the molecular mechanisms involved in the biology of these Treg cells could improve their expansion and selection to treat immune-related diseases, achieve immunosuppression-free organ transplantation and to specifically target them in cancer. We reported on the over-expression of Tribbles-1 (TRIB1) in Tregs compared to their counterpart naïve T cells and that TRIB1 interacts with the master molecule of Tregs, FOXP3, a transcription factor essential for Treg suppressive activity. These results suggest still non explored potential links between TRIB1 in Tregs biology. Our goal is thus to decipher the role of TRIB1 in the Treg homeostasis and functions, through 3 main axes: 1) deciphering the function of TRIB1 in Tregs in vitro, 2) highlighting its implication in vivo using a combinaison of immune-related models and 3) discovering the signalling pathway of TRIB1 in Tregs. These results would not only increase TRIB1 mechanistic knowledge but also increase comprehension of Treg biology and bring opportunities to identify new strategies to modulate Tregs for immunotherapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NExt ApplicationS of Quantum Computing' (NEASQC).

assistant: **Concept**

NEASQC is devoted to the emergence of practical applications of quantum computing in its NISQ era, and to the construction of a strong community. NEASQC is use-case centric and organized around 10 real use cases (UC). These UC have been defined by the industrial members and validated by the academic members as NISQ compatible. Each use case will be investigated with a rigorous methodology by an integrated team made of at least one industrial and one academic: 1-Algorithm research and design 2-Development of a prototype software 3-Qualification of the prototype with real data on real or simulated NISQ device 4-Benchmark against state-of-the-art techniques.NEASQC is coordinated by Bull, the Atos subsidiary in charge of Quantum Computing, developer of the QLM/myQLM quantum programming platform. Bull will act as the integrator of NEASQC software deliverables and will guarantee their industrial quality.An important objective of our project is to build an active European community of applied QC. As such, much attention is paid to dissemination, with a significant number of actions toward a large number of end-user communities. The project will welcome associate end users all along.NEASQC will build quantum computing open source libraries out of the use case developments. These libraries will be delivered to the European QT community all along the project, through the project portal. A ready-to-install quantum programming environment (QPE) will be built and made available for free to the community, starting from year 2. NEASQC will work with the flagship funded hardware projects to ensure the QPE is compatible with their platforms. In particular, our libraries will be optimized for each platform. NEASQC does believe in HW/SW co-design, and will define a series of use-case spec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Configurable and Adaptable Trucks and Trailers for Optimal Transport Efficiency'.

assistant: **Objectives**

Today trucks are designed and optimised towards a limited variance set of usage and for maximum payload. Future trucks-trailers are easily adaptable for each freight, load and mission. And, in the operation phase, the vehicle combination automatically adjusts itself to the actual driving environment (i.e. traffic situation, topology, and payload). This option has large potential to contribute to the achievement of the EC’s targets for reducing the consumption of fossil energy resources, increasing transport - and fuel efficiency.The objective of the project is to develop and demonstrate innovative and energy efficient trucks and load carriers for long distance transport assignments with an improved load efficiency leading to an overall 25% less energy consumption on a t.km basis and a lower impact on the road infrastructure.This is achieved by the CONCEPT proposed that is based upon the following key innovations:1. A distributed, modular, and mission adaptable Hybrid-on-Demand (HoD) driveline concept that is applicable to both, existing and future trucks,2. A pre-standard electric Hybrid-on-Demand Framework that supports a broad market introduction of hybrid commercial vehicles and provides planning certainty for future RTD activities.3. Mission-based configurable aerodynamic overall truck-trailer design (toolbox);4. Loading efficiency optimised trailer interior design (toolbox);TransFormers focus on achieving these key innovations within the existing European legal and regulatory framework in terms of dimensions, weight and loads.The main results of the project will be:- Key performance indicators and use cases- Holistic simulation study results for the design of the Hybrid on demand driveline concepts and use for optimal component selection- HoD driveline concept defi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rationality in Perception: Transformations of Mind and Cognition 1250-1550' under Horizon 2020.

assistant: **Concept**

The project RiP aims to provide a groundbreaking new interpretation of late medieval theories of mind and cognition by focusing on the influence higher cognitive (rational) powers exert on lower (sensory) ones in the neglected tradition of Augustinian philosophy of perception. Due to increasing difficulties in explaining the unity and objectivity of perceptual experience, late medieval authors came to question the dominant Aristotelian theory, with its passive account of perception and emphatic separation between sensory and intellectual functions. This led to a resurfacing of the Augustinian tradition, which is characterized by an emphasis on activity and top-down processing, built around the notions of intentionality and self-awareness. The project investigates the hypothesis that perception changes from being explained on the basis of a model of the soul that is metaphysically composite of really distinct clusters of functions to a model in which rationality permeates the functions previously attributed to lower cognitive capacities. It is the 'flow of reason', an expression found in a late sixteenth-century textbook. The project has therefore two main objectives: (1) to offer the first systematic study of late medieval theories of perception, focusing on the relation between the senses and intellect (2) to retrace the shift in late medieval philosophy of perception that led to (a) a progressive questioning of direct realism in cognition and (b) the incremental reduction of all psychological functions to the mind. The results of the project will allow a better understanding of the philosophical assumptions of late medieval theories of cognition, shedding new light on the historical background of early modern and contemporary conceptions of rationality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Toward a Euro-Mediterranean Memory: Expert Workshop on Information Systems for Arab Manuscripts'.

assistant: **Objectives**

The collective memory of the Euro-Mediterranean, of which medieval Arab manuscripts form an essential component, is currently facing unsurpassed challenges. Sweeping modernization, war and social tensions, are a few examples. They include natural catastrophes as well as humidity, termites and pollution- all these factors enhance the decay of valuable components of our past leading to a collective amnesia.This in turn undermines the bringing together of a common Euro-Mediterranean memory and a shared self image. This project will attempt to overcome this problem through the development of a pilot web portal for manuscript collections that can accommodate different data base structures into one information system that allows for search and retrieval of data using XML language accessed on the internet. Detailed studies will de carried out to determine the commonalities and differences of manuscript information systems by comparing between two information systems currently being developed at CULNAT: the first is the publicly owned astrological collection of al Azhar University and the second is a collection of Khezanaz (cases) privately owned by families in the Algerian city of Adrar; a project funded by the Memory of The World Program, UNESCO.As a result of this effort an expert meeting of regional and national experts who are also the major stockholders in the preservation of manuscript collections will take place to evaluate the pilot study and the prototype portal. Upon this assessment the experts will identify a logical framework that identifies and includes all stakeholders in order to produce a cost effective plan of action. Experts will produce a number of recommendations that will be presented to the Commission for direction in the area of increasing research and i