RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Identifying correlates of protection to accelerate vaccine trials: systems evaluation of two models of experimentally-induced immunity to malaria' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Vaccine development is an empirical process (trial and error) and involves a long, expensive clinical development pipeline to license an efficacious vaccine candidate. Better tools for vaccine evaluation are needed to adapt to a rising number of candidate vaccines entering clinical trials for many diseases. Surrogate biomarkers of immunity offer the possibility of expediting the clinical development by eliminating non-viable candidates earlier in the pipeline, shortening vaccine trial timeframes by giving a proxy measurement for efficacy and by guiding future vaccine design. In the case of malaria and other complex diseases, a surrogate biomarker of immunity has been difficult to achieve with classical immunological assays. We propose using a systems biology analytical approach in two efficacious malaria vaccination models to identify combinatorial biomarkers of protection. First, newly generated cellular transcriptome profiles and previously generated immunological read-outs common to both trials will be integrated into a database for this analysis. An already developed artificial intelligence-based analytical tool that generates biological network maps, transforms experimental data to the map and discriminates transcriptional gene signatures to physiological states (protection or susceptibility) will be applied in both vaccination models. The aim is to determine malaria signatures of protection that will then be refined and validated in an experimentally induced immunity non-human primate model. The optimized model will be further validated on additional samples from the two protective human trials. The identified biomarkers of protection will be used to produce a customised Immunome Chip, which together with traditional immunological read-outs will be used to evaluat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discovering novel antibodies derived from the human body itself to treat neurodegenerative diseases' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Neurodegenerative diseases are one of the disease fields with the highest unmet need. Decades of research have been invested in finding cures, however almost none have been successful. Antibodies have great therapeutic potential to treat these diseases as they are broadly applicable to specifically target different aspects of disease-causing processes. However, most of current non-human antibodies are limited by side-effects and a lack of specificity. Human-derived antibodies, derived from human blood samples, provide a solution for these limitations.  They are naturally designed by the human immune system to fight toxic moieties with higher efficacy and specificity and are expected to have lower side-effects when compared to antibodies of non-human origin. However a large amount of blood samples is required to identify the rarest and most specific antibodies. Mabylon is a biotechnology company that capitalizes on the human body’s own protective capability to generate antibodies against human disease. Mabylon’s unique screening platform allows identification of a “needle in the haystack” and develop fully human antibodies for diseases with high unmet medical need in the field of allergies and neurodegenerative diseases. Mabylon is currently developing several antibodies including an antibody for TDP-43, a toxic protein associated with diseases progression in ALS and FTD. ALS as a potential initial market could generate €110M in licensing revenue in 2021-2025 and €170M in royalties (5%) from 2026-2030. In addition, platform expansion towards other indications addresses a total neurodegenerative drug market worth €40B by 2022.In the HominAb project, we will investigate our market positioning, the commercial landscape, preclinical development and licensing strategy in orde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The Governance Capacity of Cooperative Housing: The Role of 'Linking Social Capital''.

assistant: **Innovation**

Cooperative initiatives in the field of housing are considered increasingly important for fostering social cohesion in European city regions. Nevertheless, the debates on the potential of third sector housing in different EU member states are currently only weakly connected. It is therefore crucial to inform these debates with timely academic research that is accessible to policy makers and practitioners in Europe.Against this background, the principal aim of the proposed project is to investigate how different governance models of housing cooperatives influence the creation of 'linking social capital'. Applying qualitative, case-study oriented research, a comparative study between the Vienna city region and the West Midlands region in England will derive conclusions on the design of governance institutions in cooperative housing which foster linkages between residents, housing managers and people in positions of influence and power in the external institutional environment.Given the high expectations of policy makers and academics towards third sector housing, the project provides a more realistic picture of cooperative housing governance and its capacity for influencing cohesive urban development through community empowerment. The proposed project is highly relevant for the European Research Area because it deepens the inter-European dialogue on the role of third sector housing for social cohesion. Furthermore, it aims at achieving a better mutual understanding between different regional schools of thought within Europe.The fellowship will also enhance the academic career prospects of the experienced researcher through advanced training in qualitative organisational research methodology and in European housing policy. The two years intensive training in a high quality
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural and functional studies of human PNPase in mitochondrial RNA metabolism' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Throughout the eukaryotic lineages, mitochondria are essential organelles that provide cellular metabolic power through oxidative phosphorylation. In the mitochondrial intermembrane space resides an exoribonuclease highly conserved in the course of evolution: PNPase. Although the activity of this enzyme has been extensively studied, its function in this compartment is poorly understood. A clue to one of its potential functions has been provided by my recent findings on the bacterial PNPase, which I discovered to switch activity from an RNA degradation mode to a stabilising mode that chaperones regulatory RNAs. As the human and bacterial enzymes are homologues, it is possible that human PNPase (hPNPase) could have a dual mode of action as well, and could participate in regulatory processes or RNA cargo transport once trapped in a non-degradative assembly. My research will address what functions are played by hPNPase present in the intermembrane space of the human mitochondria. I will characterise the full-length enzyme and its capacity to bind substrates in the degradative and non-degradative modes. In order to achieve these objectives, I will elucidate the structure-function relationship of hPNPase by cryo-electron microscopy complemented with biochemical and biophysical assays. The results will illuminate the biological roles of PNPase in human cells including its potential contributions to mitochondrial RNA trafficking. This interdisciplinary project with potential applications in human health will apply recent breakthrough advancements in cryo-EM in order to investigate the molecular basis of an intricate biological system to advance the understanding of mitochondria biology. The research effort will foster the career development of a talented researcher and contribu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Scandalisation in Contemporary European Media'.

assistant: **Objectives**

Journalism in many societies is challenged by the market power of digital intermediaries and political propaganda. However, news media still manage to capture fragmented audience attention and set the agenda when reporting scandals. Therefore, scandals are an enduring phenomenon in contemporary public discourse, with profound consequences for democracy (Burkhardt, 2018).This project focuses on mediatised scandalisation processes as a critical subject of comparative research. Scandals reveal dynamics within journalism and offer insights into the political system, as developments in one field often have direct consequences for the other or originate from one another (Mancini, 2020, p. 391). Research by Hanusch and Hanitzsch (2019) shows that journalists in some media systems support political authorities, posing challenges to independence and objectivity when reporting norm transgressions by elites. However, given the right environment, journalists emphasise investigative rigour and scepticism. Thus, media systems and journalists' roles and norms crucially shape the reporting of scandals (Eder, 2023).Against this background, the project investigates cross-national commonalities and differences in mediatised scandalisation processes across Europe. Applying such an integrated analytical framework advances understanding of the complex interplay between economic, political, and societal contexts of mediatised scandalisation. Examining how journalists report on scandals will also provide insights into journalism's democratic role in mediating public accountability.The project combines large-scale quantitative and qualitative content analysis with semi-structured interviews with journalists in three European countries. It is investigated: (1) which types of misconduct and norm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sea level and extreme waves in the Last Interglacial' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Past interglacials are periods of the earth’s history when climate was warmer than the pre-industrial, and are often considered as process-analogs for a future warmer climate. During the Last Interglacial (LIG, ~128-116 ka), polar temperatures were few degrees higher than pre-industrial, ice sheets were smaller and sea level was higher than today. Studies also suggest that waves in the North Atlantic might have been more intense in the LIG than today. Understanding sea level changes and extreme wave intensity during the LIG is key to assess the future of the world’s ice sheets and coastlines under warmer climatic conditions. For this reason, the LIG is the most studied among past interglacials, but recent research highlighted that the LIG is far from a ‘solved problem’, especially for which concerns sea level and coastal dynamics. There are in fact three relevant research gaps. First, widely accepted estimates suggest that LIG global mean sea level was 5-10 m higher than today, but recent studies proved that previously unrecognized processes concur to make current LIG sea level estimates very uncertain. Second, it is unclear if LIG sea level was characterized by rapid oscillations that caused sea level to rise abruptly at rates higher than at present (up to 10 mm per year in the LIG, compare with 3 mm per year today). A third research gap is related to the highly controversial notion that the LIG was characterized by ‘superstorms’, producing waves more intense than those observed today. In this project, we want to employ a multidisciplinary combination of methods to study Last Interglacial peak sea level, sea level variations and extreme waves. WARMCOASTS will develop both new datasets and merge methods from geology, earth modeling, surface processes modeling and hydrod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modular, scalable, multi-funtional, high power density power controller for electrical taxi' (E-TSIN), addressing dissemination and exploitation.

assistant: **Impact**

This proposal presented by Indra Sistemas and CEIT jointly, try to answer in the best way the call JTI-CS2-2014-CFP01-SYS-02-02.The referred call and this associated proposal are framed inside of the packet 4.1.2.4 (Modular power controller for advanced landing system) of the System ITD for the Cleansky2 project.This project will develop a next generation power controller for electric taxi. This controller shallfeature increased power density, bidirectional power conversion, modularity, scalability, and multifunctionalityto support wide range of aircraft applications.Inside this global project of aircraft electrical moving on ground (e-TAXI), this concrete WP, try to answer the necessity of electrical power converters to:- Supply new electrical motors inside of the landing gear system (getting energy from electrical sources inside the aircraft)- Re-charge dedicated batteries inside the aircraft for the landing gear system. This function will help to have additional power available in batteries to be used when necessary, as in acceleration moments. Moreover, the re-charge will be done when aircraft speed on ground is enough or there is a necessity of braking (producing electrical braking over the motors).Then, proposal solution in this call develops a solution answering both functions and getting a global optimization of the system. This solution is done in accordance with aeronautical standards (environmental constrains), where the participants in this proposal have a vast experience.This proposal is presented by the consortium INDRA & CEIT that have all competences and skills to develop this project in time and performances, based in its experience in bidirectional and modular power electronic converters and well-known aeronautic standards, rules and process, more when
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ANTOFERINE: An innovative eco-friendly process for chemical solvent free extraction of bioactive antifungal polyphenols from vineyard waste.' (ANTOFERINE), addressing dissemination and exploitation.

assistant: **Impact**

The agro-food sector is facing today crucial challenges. With a global population expected to reach 9 billion by 2050, meeting the global demand for food supply would not only require increasing production, but also to prevent food losses. Close to 50% of the global fresh produce, mostly fruits & vegetables, is lost in the post-harvest stage due to spoilage during transport and storage, with 80% caused by fungal contamination. Besides damaging product quality, fungal growth poses a risk to consumers due to secretion of mycotoxins, carcinogenic and immunogenic metabolites from fungi. The cumulative cost of post-harvest losses exceeds €200 billion annually. To prevent these losses, post-harvested produce has been traditionally protected with chemical-based solutions. However, besides the direct risk for applicators, these products also leave residues that are hazardous for consumers and the environment. Trying to find a balance between the prevention of losses and reducing risk for consumers, the EC has set residue allowance limits for synthetic compounds and seeks to replace them with natural alternatives. In response, we at Antofénol present an innovative antifungal solution of natural origin to protect fruits & vegetables in the post-harvest stage. The efficacy of our product relies on its unique composition of polyphenol extracts, obtained through a solvent-free extraction process that isolates them from vineyard waste. Importantly, besides contributing to reduce the huge post-harvest losses that affect the food sector, we would be contributing to the European circular economy by promoting valorization of an abundant agricultural waste. Altogether, the main goal of this project is to finalise the development of our biocontrol product and take our extraction process to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exposing the glial metabolism - common link to brain damage' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

European population is rapidly aging. While it was commonly believed that brain aging leads to neuronal loss, recent studies found that instead the volume of white matter (WM) decreases and WM lesions develop with age. WM degeneration is also a hallmark of multiple neurological disorders including Alzheimers disease or multiple sclerosis. Understanding cellular responses to WM injury is therefore critical for design of regenerative therapies of central nervous system (CNS). The European population is also increasingly overweight. Obesity is associated with higher risk of multiple sclerosis and other neurological diseases and leads to systemic low-grade inflammation modulating functions of the immune cells. While this paradigm has been extensively studied in peripheral tissues, effect of diet on microglial states in CNS is poorly understood. I hypothesise that high-fat diet disrupts metabolic response of microglia to WM injury and impairs regeneration. My proposal aims to identify diet-altered microglial pathways and how to target them for promoting recovery after injury. For this goal, I will use the single cell and spatial transcriptomics to characterize in detail how WM injury and obesity alters cellular phenotypes. However, currently no method can link the metabolic state of the cell with its transcriptome. I will establish method that combines metabolic measurements with single cell RNA-Seq in mouse models of high-fat diet and demyelination. In addition, I propose to integrate spatial transcriptomics with electron microscopy as an innovative approach to visualize lipid-loaded microglia and link their morphology to the transcriptomic state. This project will provide critical new knowledge of mechanisms of WM repair. The fellowship will allow me to become expert in ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Integrated energy solutions and new market mechanisms for an eXtended FLEXibility of the European grid'.

assistant: **Objectives**

The X-FLEX project proposes a set of integrated solutions that will facilitate the optimum combination of decentralised flexibility assets, of both on the generation (DER) and on the demand side (V2G, power-to-heat/cold, batteries, demand response) enabling all parties, including final prosumers, to offer their flexibility in the local and wholesale market creating benefits to all the actors in the smart grid value chain. This flexibility will make it possible to maintain a stable and secure electricity system with a growing role of variable renewable generation, yet resilient to extreme climate events.Up to now, the projects and research activities in this area have been focused mainly on specific energy sources and actors, considering only a very limited and isolated part of the distribution network, leaving aside all the opportunities existing throughout the flexibility offered by the energy value chain.In this context, X-FLEX will propose a new concept that will integrate and create synergies among all energy flexibility sources and technologies, promoting cooperation of all the actors of the smart grid and energy market, in an efficient and cost-effective manner. Through this holistic approach, X-FLEX aims to create the optimal combination of decentralised flexibility assets located along the whole energy value chain and new market mechanisms, providing benefits to all the actors of the smart grid and energy market, offering an all-win scenario. These X-FLEX project solutions will be tested in real conditions in 4 pilot sites in 3 EU Member states (Bulgaria, Slovenia and Greece), with different needs and socioeconomic and technological boundaries, involving multiple flexibility assets (batteries, power to heat/cold, vehicle to grid and other storage solutions) and