RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The genus Digitalis: Molecular taxonomy, preservation, active constituents and therapeutic applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The topics of this joint exchange programme are all related to a specific plant genus of commercial interest and its taxonomy, the propagation and investigation of endangered species of this plant genus, the natural products used in medicine occurring in Digitalis plants, and the isolation, structure elucidation and biological testing of some of the rare but pharmacological relevant cardenolides. Objectives are (1) Taxonomically critical Digitalis species and subspecies will be (re)-examined by molecular taxonomy, using the progesterone 5β-reductase gene as a molecular marker, and chemotaxonomy by cardenolide profiling, using HPLC, (2) plant tissue cultures of endangered Digitalis species will be established and used in plant propagation. Hairy root cultures of selected species will be established for fundamental studies on cardenolide formation, (3) the structures of important cardenolides will be elucidated by NMR and bulk quantities of selected cardenolides will be produced, (4) antiviral and antiproliferative effects of individual cardenolides will be studied. Cardenolides will be screened for their pharmacological profiles (potential and selectivity). The objectives aim at intensifying circumstantial ongoing co-operations and exchange of materials and people in a more reliable and coordinated way. The profiles of expertise of the various partners are complementary and researchers from Turkey, Brazil, Germany and Portugal are involved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Palaeogenomes of a lost world: Ancient bovids of the submerged Palaeo-Agulhas Plain of southern Africa' in the context of a Horizon 2020 call.

assistant: **Objectives**

The recent, detailed palaeoecological characterisation of a drowned ecosystem off the southern coast of Africa, known as the Palaeo-Agulhas Plain (PAP), has placed subfossil collections of African bovids from archaeological sites along this coast into meaningful environmental and temporal context. For the excellent work done to describe this palaeoecosystem, genetic characterisation of the mammals that roamed its plains is lacking, despite an abundance of subfossils available. In this Action, I will use palaeogenomics techniques to generate ancient mitochondrial genomic data of six African bovid species spanning five time periods over the past ~100,000 years, including the present. The target species represent three broad feeding guilds: grazers- Cape buffalo, long-horned buffalo (extinct) and southern reedbuck, a mixed feeder- common eland, and browsers- grey rhebok and Cape grysbok. These data will be used to investigate drivers of temporal changes in genetic diversity, such as climate change, range-size change due to the emergence and submergence of the PAP with changing sea levels, the emergence of pastoralism in human societies, over-hunting by colonial settlers, and recent population fragmentation, and whether different feeding guilds were affected discordantly. The project will be hosted by Assoc. Prof. Eline Lorenzen, a respected expert in the field of African bovid phylogeography and ancient DNA, at the GLOBE Institute at the University of Copenhagen, which houses a world-leading ancient DNA facility. This Action will improve my current scientific and transferable skills and will provide the opportunity for me to learn valuable new skills that will considerably enhance my future career prospects. In this Action, I will generate the first population-level palaeo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Patterning of transparent organic conducting materials for electronics', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Research on organic (nanostructured) materials and patterning technologies for the development of 'integrated plastic circuits' for low cost electronic applications such as plastic displays, intelligent packaging labels and electronic paper. Printing technologies and the choice of materials raise many technical and technological challenges with regard to integration in prototypes and characterization of resulting properties. As development cycles for product development decreases in time, industry would benefit greatly from a more direct approach in the design of material formulations. Important advances in this field are possible by the ability of a combinatorial approach and the variety of specialized characterization techniques to study the different organic (nanostructured) materials. The post-doctoral fellow will be involved in a feasibility and characterization programme of new functional materials and processes and in an identification of possible new electronic applications. The study will be performed in close collaboration with the in-house material scientists of the departments of New Material research, Chemical building block discovery, the analytical characterization specialists and the process development group of the Research Center for Electronic Imaging and external academic and industrial partners. (i.a. Laboratory for Display Technology, University of Stuttgart, Prof. Fruehauf)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Baeyer Villiger Monooxygenases as Biocatalytic Parts for Monomers of New Lactone-based Polymeric Materials' (Monopoly) targeting Horizon 2020.

assistant: **Abstract**

Recent advances in the development of both experimental and computational protein engineering tools have enabled a number of further successes in the development of biocatalysts ready for large-scale applications.The production of monomers from cheap, readily available components (e.g. terpenoids) for sustainable biopolymer synthesis is a growing area of interest. Biomaterials composed of lactone monomers have been used to produce polyurethanes.The present research proposal is focused on the deep understanding of catalysis by newly identified BVMO enzymes, realized through detailed structural and functional analysis of enzyme mechanisms and substrate/coenzyme recognition. This project will involve multidisciplinary training, with clear objectives in the technical areas of synthetic biology, proteomics, structural biology and biophysical chemistry. This project will allow me to work on structure/function relationship of proteins and to extend my knowledge in metabolic pathway engineering especially in understanding of monooxygenases.The objective will be to identify new Baeyer Villiger monooxygenases biocatalysts that have the appropriate biocatalytic and stability characteristics to enable lactone monomer synthesis. The methods would generate novel structural and biocatalytic data to provide a comprehensive toolkit of flavin-dependent BayerVilliger monooxygenases that are suitable for exploitation in lactone monomer synthesis. These new biocatalysts will be used to construct new strains of E. coli that are capable of producing the target lactone monomers in high yield. The immediate outcomes will be new structural information (native and variant forms of the enzymes); new biocatalytic parameters (reactivity profiles with target substrates; stereoselectivity; conversion;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Low dimensional Riemannian and Lorentzian geometry of constant curvature' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The aim of the present project consists in detecting fundamental structures, which allow a unified understanding of low dimensional Riemannian and Lorentzian manifolds of constant curvature.The point of view is that of Wick rotation-rescaling theory recently outlined by Benedetti and Bonsante. In this framework ends of geometrically finite hyperbolic manifolds support a natural Lorentzian metric for any fixed constant curvature.The first objective is to investigate the relationships between classical ending invariants and these ending spacetimes". This should provide a new insight in both hyperbolic geometry and gravity in dimension 3. On the other hand the Wick rotation-rescaling theory should be further extended in order to include the case of ends of an y complete hyperbolic 3-manifolds of finite type.The present project falls within the timeline research area of 3D-gravity that has involved common efforts of both Mathematicians and Physicists in last years. Actually a deep motivation of the project is t o give a strong geometric support to recent 3D quantum field theories."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'LARGE SCALE INTEGRATION OF AC PV MODULES INTO A NOISE BARRIER ALONG A HIGHWAY NEAR AMSTERDAM' to be submitted under Fourth Framework.

assistant: **Abstract**

- Installation of an innovative 210 kWp grid connected PV system, production of 172000 kWh per year;- reduction of system costs on an overall level through volume, integrated design and prefabrication;- Evaluation of technical, architectural and economical aspects;- Investigations of performance and impact on utility grid of a large number of parallel AC modules, including disturbances, harmonics, spikes, surges etc.1. Innovation :- fully integrated design of the entire system from the beginning, including serviceability aspects- technical and organisational involvement of all project partners from the start; energy company, municipality, road directorate, building company, governmental organisations, PV consultants- development and demonstration of innovative design approach and prefabrication mounting methods- architectural integration of larger AC PV modules into a new to build 1650 m long noise barrier, including engineering of rather high structures and crossing a river (200 m of length on a bridge)- multi-functionality of PV modules : energy production and noise reduction2. PV cells in a noise barrier3. Total costs Hfl.4972500 Electricity production 172000kWh/y Conventional energy production Hfl.0.07/kWh4. Monitoring for at least 2 years
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'NMR structures of membrane proteins, complexes and lipid assemblies; a dedicated wide-bore ultra-high-field MAS NMR spectrometer for biological research' under Fourth Framework.

assistant: **Concept**

The objectives are to establish and to validate ultra high field Magic Angle Spinning NMR technology required for comprehensive structure determination using multidimensional correlation spectroscopy. This involves the construction of a fully operational prototype spectrometer with dedicated high-speed MAS probes, operating at ultra high field ( 750 MHz) with excellent long-term stability, and the construction of the associated ultra high field wide-bore magnet, in a unique partnership between scientific key laboratories and the only major NMR manufacturer in Europe. A demonstration phase will overcome the techno-economic uncertainties associated with the implementation of the spectrometer and the new technology. The novel instrumentation will be available to all biological solid state NMR users in Europe. The user exploitation will prove the concepts for MAS NMR structure determination, and will demonstrate routine specification of ligand-protein interactions for biomolecules with the desired functions (e.g. drugs, hormones and membrane protein receptors) using multi-spin and specific isotope labeling of genuine subcellular entities, as defined in Area 6.1, Structural biology, research tasks 6.1.1, 6.1.2 (prominent) and 6.1.3. The long-term goal is to establish flexible technological means to obtain comprehensive molecular information, at atomic resolution, for widely different types of molecules or subjects, and to relate this to function, eg. for an essentially unperturbed membrane protein receptor when in the membrane. A preparation has confirmed the feasibility of the novel instrumentation. Multidimensional homo-nuclear and hetero-nuclear test-experiments using multiple 13C labeled and 2H diluted samples have been performed to determine the instrument requirements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Design for Structural Safety under Extreme Loads' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content The future of European shipyards depends on their ability to produce new generation ships at competitive costs. With ever increasing traffic density, safety is increasingly becoming key for competitiveness. DEXTREMEL is submitted to respond to the industrial need for design methods to ensure structural safety and subsequently passenger safety of ships in adverse environments. The prevention of accidents as well as the management of accidents if they occur is considered a key issue in the future development of safe ships. To meet these requirements, the master plan of the Maritime Industry Forum (MIF) identified design for safety" and "implementation of a risk assessment process in ship design" as research needs. In particular, the need for methods to assess "damage robust designs" was identified. The safety of RoRo ferries was also identified as key research area by the Maritime Systems of the Future task force. DEXTREMEL will provide methods to predict the residual structural strength of damaged RoRo ferries in extreme conditions. Based on the simulation of a ship's behaviour under realistic operating conditions, these methods aim at the rapid evaluation of new concepts and configurations. The influence of systematic design parameter variation on the structural integrity under extreme loads will be investigated and safe structural designs will be identified. The results of DEXTREMEL will enable the quantification of risks associated with (total) loss of structural integrity due to extreme and / or accidental loads, such as collision and grounding loads, wave loads acting on bow doors, and loads on deck structures caused by green water shipping. In addition, the formulation of prenormative guidelines will contribute to new rules concerning RoRo pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards a systemic view of the circadian clock: Integration of miRNAs into the molecular, cellular and neural circadian networks' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Circadian (24hs) rhythms in locomotor activity are one of the best-characterized behaviors at the molecular, cellular and neural levels. Despite that, our understanding of how these rhythms are generated is still limited. A major shortcoming of the current approaches in the field is that they depict the circadian clock as a mere addition of steps (and/or combination of parts). By doing so, the circadian oscillator is portrayed as a static rather than a dynamic system. We have recently shown for the first time that miRNA-mediated regulation plays a role in circadian timekeeping in Drosophila. In the present project we will exploit complementary and cutting-edge approaches that will provide an integrative and comprehensive view of the circadian timekeeping system. As we believe that miRNAs are key mediators of this integration, we will dissect their role in the circadian clock at the molecular, cellular and neural levels in Drosophila. At the molecular level, we will determine the mechanisms, and proteins that mediate the circadian regulation of miRNAs function. Moreover, by the use of high-throughput methodology we will assess and characterize the impact of translational regulation on both the circadian transcriptome and proteome. At the cellular level, we plan to determine how this type of regulation integrates with other circadian pathways and which specific pathways and proteins mediate this process. As a final goal of the proposed project we plan to generate a complete genetic interaction map of the known circadian regulators, which will integrate the different molecular and cellular events involved in timekeeping. This will be a key step towards the understanding of the circadian clock as a dynamic adjustable process. Last, but not least, we will study the role of m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Discovery of counter defense strategies of bacteriophages against bacterial immunity'.

assistant: **Concept**

Tight co-evolutionary interactions of bacteria and their viruses, termed bacteriophages or phages, lead to continuous selection towards adaptation of the host and counter-adaptations of the parasite. Studying this evolutionary arms race resulted in discovering multiple sophisticated defense mechanisms of bacteria, such as CRISPR-Cas and restriction-modification systems. However, the diversity and mechanisms of action of counter-defense strategies of phages remain largely unknown. In this proposal, I will address this problem.The pan-genome of the phages is proposed to encode for proteins with counter-defense function. I will test this hypothesis using the largest, fully genome sequenced virus-host interaction network to date treasured in the host lab. I will combine comparative population genomics with computational biology, classical molecular genetics, transcriptomics, and proteomics. This approach will allow me to address my research objectives: (1) to identify counter-defense proteins of the phages, (2) validate the counter-defense properties, and (3) determine at which stage of phage infection the counter-defense occurs.This research will allow me to elucidate the diversity of previously unknown counter defense strategies of phages and expand our knowledge of their mechanism of action. Importantly, my approach shifts the paradigm of studying bacterial defense systems and the escape mechanism of phages and will open up many novel avenues in bacterial immunity and microbial population genomics. Implementation of the proposed project will enhance my proficiency by improving and diversifying my experimental and computational science skills and boosting my transferable skills, such as scientific communication and writing, project management, and networking. This altoget
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Development of environmental modules for evaluation of toxicity of pesticide residues in agriculture'.

assistant: **Objectives**

DEMETRA' s objective is to produce software for toxicity prediction of pesticides and related compounds, for evaluation within the Dossier for pesticide registration. We will involve end-users from government and industry and ecotoxicologists to get a sound basis. Suitable data sets will be defined, with pesticides and their toxicity values in 5 organisms. We will calculate chemical descriptors of pesticides. We will develop many models using advanced computational tools, like multivariate analysis, neural networks, fuzzy logic, machine learning, genetic algorithms, etc. We will combine the most successful models within a hybrid system. This process will be done in parallel for the 5 endpoints. The so obtained 5 hybrid systems will be put on the web for free access. Further dissemination will be obtained within a workshop.