RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Systems analysis of pancreatic tumor cell phenotype dependence on the spatial regulation of oncogenic Ras signaling' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Over the last several years me and my team have uncovered the reaction cycles that dynamically maintain the spatial organization of the Ras proto-oncogene products on cellular membranes. The quantitative microscopic imaging approaches in close iteration with computational systems dynamic analysis that we developed in the course of these studies were key to understand these reaction systems which were termed “spatial cycles”. Recent exciting results from my laboratory show that interference with spatial cycles, that normally maintain all major Ras isoforms on the plasma membrane, affects the signaling output from oncogenic Ras and thereby inhibits the growth and survival of KRas transformed murine pancreatic cancer cells. The purpose of the proposed multi-disciplinary project is to quantitatively assess in situ how the spatial organization of KRas affects the state of intracellular growth factor signaling networks and thereby maintains the phenotype of murine pancreatic cancer cells. A major objective that integrates the multiple levels of research in this proposal is whether and how the pharmacological inhibition of spatial cycles affects the growth of oncogenic KRas driven pancreatic tumors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Endocrine disrupters : exploring novel endpoints, exposure, low-dose-and mixture-effects in humans, aquatic wildlife and laboratory animals' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

In the EU, there are significant human and wildlife health problems that stem from 'endocrine disruption'. What is unresolved is whether human/wildlife exposure to endocrine disrupting chemicals (EDC) from the environment plays any causal role in these developmental disorders. The motivation of EDEN is to meet this challenge by addressing common problems in wildlife and human hazard assessment in one coherent approach. It will produce data about the occurrence of mixed exposures to EDC in humans and fish and develop new experimental models that allow more meaningful extrapolations from animals to humans. It will produce data about low-dose- and mixture effects of EDC that are directly relevant to hazard and risk assessment. It will provide new insights into indicators of reproductive health of European citizens and will help to produce the scientific basis for a coherent strategy for dealing with EDC in the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Novel Mechanism of Behavioural Change' (ChangeBehavNeuro) under Horizon 2020.

assistant: **Objectives**

Understanding how values of different options that lead to choice are represented in the brain is a basic scientific question with far reaching implications. I recently showed that by the mere-association of a cue and a button press we could influence preferences of snack food items up to two months following a single training session lasting less than an hour. This novel behavioural change manipulation cannot be explained by any of the current learning theories, as external reinforcement was not used in the process, nor was the context of the decision changed. Current choice theories focus on goal directed behaviours where the value of the outcome guides choice, versus habit-based behaviours where an action is repeated up to the point that the value of the outcome no longer guides choice. However, in this novel task training via the involvement of low-level visual, auditory and motor mechanisms influenced high-level choice behaviour. Thus, the far-reaching goal of this project is to study the mechanism, by which low-level sensory, perceptual and motor neural processes underlie value representation and change in the human brain even in the absence of external reinforcement. I will use behavioural, eye-gaze and functional MRI experiments to test how low-level features influence the neural representation of value. I will then test how they interact with the known striatal representation of reinforced behavioural change, which has been the main focus of research thus far. Finally, I will address the basic question of dynamic neural plasticity and if neural signatures during training predict long term success of sustained behavioural change. This research aims at a paradigmatic shift in the field of learning and decision-making, leading to the development of novel intervent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Joint European Research Infrastructure of Coastal Observatories: Science, Service, Sustainability - JERICO-S3' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

amJERICO-RI: Joint European Research Infrastructure of Coastal Observatories – a system of systems strengthening the European network of coastal observatories providing a powerful and structured European Research Infrastructure (RI) dedicated to observe and monitor the complex marine coastal seas and to: (i) provide services for the delivery of high quality environmental data, (ii) access to solutions and facilities as services for researchers and users, (iii) create product prototypes for EU marine core services and users, (iv) support excellence in marine coastal research to better answer societal and policy needs. JERICO-S3 will provide a state-of-the-art, fit-for-purpose and visionary observational RI, expertise and high-quality data on European coastal and shelf seas, supporting world-class research, high-impact innovation and a window of European excellence worldwide. It will significantly enhance the current value and relevance of the JERICO-RI, through the implementation of the science and innovation strategy elaborated as part of the JERICO-NEXT project. JERICO-S3 is mainly targeting a more science integrative approach to better observe the coastal ecosystem, raising up the scientific excellence, with consideration of the regional and local ecosystems; the preliminary development of an e-infrastructure in support to scientists and users by offering access to dedicated services; progress on the design of the RI and its strategy for sustainability. Major user-driven improvements will be realised in terms of observing the complexity of coastal seas and continuous observation of the biology, access to facilities, data and services, best practices and performance indicators, innovative monitoring strategies, cooperation with other European RIs (EuroARGO, EMSO, AQUAC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A novel approach to elucidate vaccinia virus three-dimensional structure: characterization by electron tomography', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The project aims at getting a much better understanding of vaccinia virus (VV) by obtaining for the first time 3-dimensional (3D) images of the virus in different stages. Vaccinia, which was successfully used as a vaccine to eradicate smallpox, is an attractive candidate for cancer therapy and vaccination programs using DNA-recombinant technology.VV belongs to the poxvirus family, the most evolved group of viruses, and has developed a very complex structure and life cycle. Many aspects of vaccinia remain poorly understood, when not openly controversial. Electron microscopy characterization is obscured by the limitations of the conventional 2D techniques. The novel approach of electron tomography offers a powerful tool to elucidate the 3D structure of the virus. Specifically, electron tomography will be applied to the predominant infectious form of the virus (the intracellular mature virus), the isolated internal core undergoing transcription, and to thick sections preparations of infected cells.With the resulting models and their combination, we will be able to provide a detailed 3D description of these viral forms and the transformation process of the virus. The home laboratory will be the group headed by Dr. Koster at Utrecht University. However, the project will be carried out in close collaboration with Dr. Gareth Griffiths and Dr. Krijnse-Locker's group, at the EMBL in Heidelberg. The EMBL group has more than ten years work experience on VV, whereas Dr. Koster's group is one of the leading groups in electron tomography.Actually, only two other laboratories in Europe and about ten worldwide can equal the facility in Utrecht. From a personal point of view, learning from both different expertises will allow me to considerably widen my training as an electron microscop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Lyotropic liquid crystal properties of Polycatenar Mesogens' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposal will bring to the EU a most talented Russian researcher with a unique training in the solvent-induced (lyotropic) properties of liquid crystals. The proposed study has its origins in an initial visit made by the applicant to the Exeter group w here she established, for the first time, lyotropic liquid crystal properties of polycatenar materials in non-aqueous solvents. The programme will address a detailed understanding of the factors that control and influence this behavior, initially using a series of polycatenar silver complexes whose thermotropic properties are well documented. The aim is to control the phase behaviour predictively. It is then proposed to study representative examples of other polycatenar liquid crystals and to apply the kno wledge gained in the first part of the proposal to the control of their lyotropic organisation. It is planned that the work carried out under this programme will form the basis for an ongoing collaboration between applicant and host once the fellowship is ended as the expertise of the two partners is highly complementary. The research area is highly topical as liquid crystals represent an area of real strength within the EU, and the relationship that liquid crystal systems can play in the realization of the rge supra-molecular structures which may mimic biological constructs or may have applications in areas such as photonics, is emerging from EU-led science.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High precision and scalable indoor positioning system', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Danish SME GamesOnTrack will target a major market opportunity through the development of an innovative high precision indoor positioning system (GT POSITION). The GT POSITION system will address the current market need for indoor positioning systems with high precision and scalability, being of particular interest for the indoor robotics and tracking systems industries. The GT POSITION system is capable of indoor positioning of static and mobile objects with extremely high precision – 10 mm. Also, GT POSITION has high scalability i.e. the location of thousands of objects in a vast area could be determined at same time, without losing the high precision capacity. By ensuring and demonstrating a maximum level of precision, scalability and simplicity at an affordable price, we will attain a key differentiating factors in order to gain access to the market.Initially, this will require a Phase 1 feasibility study that will give us a clear direction for our demonstration and market replication strategies. Later, based on proven feasibility, in the Innovation Project (Phase 2) we will need to generate full-scale showcases, which demonstrate the technical and economic benefits of our solution, to generate enough consumer confidence and facilitate broader market uptake. If objectives for Phases 1 and 2 are successfully achieved, we will be favourably positioned towards a very large opportunity for GamesOnTrack. Accordingly, we foresee a cumulative revenue of more than €18.5 million, 5 years after commercialization of the novel GT POSITION system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'AI-powered eVolution towards opEn and secuRe edGe architEctures' (VERGE).

assistant: **Innovation**

VERGE will tackle evolution of edge computing from three perspectives: “Edge for AI”, “AI for Edge” and security, privacy and trustworthiness of AI for Edge. “Edge for AI” defines a flexible, modular and converged Edge platform that is ready to support distributed AI at the edge. This is achieved by unifying lifecycle management and closed-loop automation for cloud-native applications, MEC and network services, while fully exploiting multi-core and multi-accelerator capabilities for ultra-high computational performance. “AI for Edge” enables dynamic function placement by managing and orchestrating the underlying physical, network, and compute resources.  Application-specific network and computational KPIs will be assured in an efficient and collision-free manner, taking Edge resource constraints in to account. Security, privacy and trustworthiness of AI for Edge are addressed to ensure security of the AI-based models against adversarial attacks, privacy of data and models, and transparency in training and execution by providing explanations for model decisions improving trust in models.VERGE will verify the three perspectives through delivery of 7 demonstrations across two use cases - XR-driven Edge-enabled industrial B5G applications across two separate Arçelik sites in Turkey, and Edge-assisted Autonomous Tram operation in Florence.  VERGE will disseminate results to academia, industry and the wider stakeholder community through liaisons and contributions to relevant standardization bodies and open sources, a series of demonstrations showing progression through TRLs and by creating an open dataspace for enabling public access to the datasets generated by the project.


**Keywords:** Edge computing, Artificial intelligence, Security and trustworthiness, Extended realit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A combined diagnostic and targeted gene therapy platform for brain tumor relapse' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Emergence of therapy resistance is a major cause of death following conventional chemotherapy and radiation for children and adults with malignant brain tumors. It is imperative to find novel options to target therapy-resistant brain tumor populations to save lives. We propose a novel platform providing a prognostic tool and a suicide gene therapy tool using engineered viruses. It involves targeting freshly biopsied cells from brain tumor patients with our strategy in combination with standard therapy to predict risk of patients developing relapse and a gene therapy suicide tool to remove cells causing relapse. Previous suicide gene therapies have only used viruses hitting dividing tumor cells. Our strategy will use an enigneered virus targeting non-dividing tumor cells that we know escape standard therapy. After removing the tumor bulk using standard treatment, we propose to use our virus with a marker for diagnostic purposes or a with a suicide gene that will be activated by a prodrug to eradicate therapy-resistant cells. Prodrug administration before recurrence will eliminate relapsed cells once they start dividing and become dangerous.The impact of our strategy will be high, providing health care professionals with a better tool to identify patients at high risk of developing recurrence. Such patients can receive a better, more tailored treatment that will not only increase their chance of survival but also reduce their time under hospital care and rehabilitation. We protected our strategy with a filed patent and assessed our regulatory needs. We completed a market analysis to evaluate market size and potential benefit for cancer patients. We have disclosed competitors but also potential collaborators that can cofinance and move our strategy forward to in vitro diag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spectroscopic Profiling of Electronic Resonances in Strongly Correlated Systems via MR-ADC' to be submitted under Horizon Europe.

assistant: **Abstract**

Electronic resonances are ubiquitous in electron-molecule scattering, appearing as metastable continuum states that underpin key physical and chemical processes like autoionization, Auger decay, and Interatomic Coulombic Decay (ICD). Unlike bound states, these resonances exist within the continuum and eventually decay, posing a significant challenge for traditional Hermitian quantum mechanics, which cannot directly map resonances to discrete states. To address this, non-Hermitian quantum mechanics offers a framework that allows the quasi-bound nature of resonances to be analyzed through bound-state methods. While one-electron decay processes are relatively well described by single reference methods, two-electron decay mechanisms, including Auger decay and ICD, are significantly more complex due to their dependence on multielectronic configurations, requiring advanced treatment of electron correlation. As a result, multi-reference methodss offer a more robust framework for capturing these decay processes. This project aims to develop an innovative, computationally efficient method based on multireference theory to study electronic resonances in strongly correlated systems. To achieve this, I will integrate the recently developed multireference algebraic diagrammatic construction (MR-ADC) theory with non-Hermitian quantum mechanics. Collaboration with experts across molecular resonances, spectroscopy, quantum dynamics, and quantum chemistry will ensure cross-disciplinary knowledge transfer, advancing our understanding of electronic resonances and their broader applications.


**Keywords:** Resonance, Electron-molecule scattering, Non-Hermitian quantum mechanics, Multireference Algebraic Diagrammatic Construction (MR-ADC) theory, Electronic structure, Spectroscopic propert
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'STUDIES ON THE BACTERIAL STRESS RESPONSE AND STRESS-INDUCED CROSS-RESISTANCE', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Many bacteria, including human and animal pathogens can acquire a high-resistance state as a consequence of exposure to stress. Since in their natural environments, bacteria seldom encounter conditions that allow exponential growth, understanding the mechanism/s behind stress-induced cross-resistance is of uttermost importance for the control of bacterial populations. In particular, the epidemiology and virulence of many human, animal, and plant pathogens appears to be related to stress-induced cross-resistance and phenomena such as biofilm formation appear to be the direct consequence of exposure to environmental stress. Therefore, understanding these bacterial survival strategies has important medical and economical implications. The research proposed here aims at the characterization of the molecular details behind the strategies used by two different Gram negatives, Escherichia coli and Vibrio anguillarum, for the development of stress-induced cross-resistance.E. coli is the organism for which the most detailed picture of cellular physiology exists and has been commonly used as a model for the study of the bacterial protein synthesis and the response to stress. My previous research with this organism has uncovered an important link between the ribosome and the process of stress-induced cross-resistance. The molecular details of this phenomenon will be explored in Specific Aim I.V. anguillarum is the fish pathogen which causes vibriosis, a devastating disease affecting aquaculture. Therefore, there exists high economic interest in developing methods for the control of this bacterium. Increased virulence in V. anguillarum appears to be related to iron deficiency, a common type of environmental stress. The goal of Specific Aim II is to study the cellular response to ir