RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Particle composition in relativistic jets', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Relativistic jets launched by supermassive black holes are the most extreme and energetic persistent phenomena in the Universe. They are capable of accelerating particles to energies inaccessible by particle accelerators on Earth, and deposit enormous amount of energy in their surroundings during their lifetime. They are believed to have a significant impact on galaxy evolution via feedback mechanisms. Yet, despite decades of studies, one of the most fundamental properties, the composition of these jets is still unknown. The jets can consist of either electron-positron pairs, electron-proton plasma where also protons are present and accelerated, or an admixture of the two. The composition affects the power of the jet and the presence or lack of hadrons is a crucial ingredient in modelling the multi-wavelength and multi-messenger emission of these jets. If the jets are hadronic, they are likely the origin of the highest energy cosmic rays.Circular polarization is the only direct way to determine the particle composition of jets, and we have designed a project that will overcome limitations of previous programs to finally resolve the particle composition of relativistic jets. Previously, this has only been attempted on individual objects at low radio frequencies, or using single-frequency data lacking the required discriminating power. PARTICLES will deliver the first multifrequency-radio high-cadence observations of relativistic jets in total intensity, linear, and circular polarization for a sample of objects. In parallel, we will conduct very long baseline interferometry observations to connect our light curves with the spatially resolved structures in the jets. This unprecedented dataset will be combined with radiative transfer simulations, crucial for modelling the o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CAPTURING THE PHYSICS OF LIFE ON 3D-TRAFFICKING SUBCELLULAR NANOSYSTEMS' in the context of a Horizon 2020 call.

assistant: **Objectives**

Which physical principles govern life regulation at the level of subcellular, membrane-enclosed nanosystems, such as transport vesicles and organelles? How do they achieve controlled movements across the crowded intracellular world? Which is the structural and functional organization of their surface and their lumen? This is only a small subset of key open questions that the biophysical approach envisaged here will allow to answer directly within living matter, for the first time.Thus far, state-of-the-art optical microscopy tools for delivering quantitative information in living matter failed to subtract the natural 3D movement of subcellular nanosystems while preserving the spatial and temporal resolution required to probe their structure and function at the molecular level.CAPTUR3D will tackle this bottleneck. An excitation light-beam will be focused in a periodic orbit around the nanosystem of interest and used to localize its position with unprecedented spatial (~10 nm) and temporal (~1000 Hz frequency response) resolution. Such privileged observation point will push biophysical investigations to a new level. For the first time, state-of-the-art imaging technologies and analytical tools (e.g. fluorescence correlation spectroscopy), will be used to perform molecular investigations on a moving, nanoscopic reference system.The insulin secretory granule (ISG) is selected as a paradigmatic case study. Key open issues at the ISG level are selected, namely: (i) ISG-environment interactions and their role in directing ISG trafficking, (ii) ISG-membrane spatiotemporal organization, (iii) ISG-lumen structural and functional organization, (iv) ISG alterations in type-2 diabetes (T2D). These issues will be tackled directly within human-derived Langherans islets.CAPTUR3D is env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Intercroping of cereals and grain legumes for increased production, weed control, improved product quality and prevention of N-losses in European organic farming systems'.

assistant: **Objectives**

Organic farming is increasing in Europe. However, the production of cereals and protein crops (pea, bean etc.) needs to be increased in organic farming to fulfil the requirement for organic feed and food in Europe from 2005. Intercropping, which is the simultaneous growing of two or more crop species on the same land, can contribute to this overall goal. The objective of this multidisciplinary project is to determine the potential for intercropping in European organic farming. In field pot and on-farm experiments in four European countries we will determine: the intercrop yield advantage and stability, new intercropping designs, the multiple nutrient use, monitor effects on weeds and diseases, and determine the effects of intercropping on the quality of products for food and feed. A simulation model will be developed to model grain legume-cereal intercrops. The project is expected to contribute to an increased use of intercropping and the associated beneficial effects, such as environmentally friendly production, ecological management of pest and weeds and healthy products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Host molecular and cellular responses to anti-cancer drug treatment as a potential biomarker for treatment outcome' (HOSTRESPONSE).

assistant: **Innovation**

Chemotherapy remains one of the most common treatment modalities for cancer. It is typically administered in cycles of bolus injections following 21 days of drug-free break periods. However, tumor regrowth between drug intervals is often observed, due in part, to rebound angiogenesis. Our previous studies demonstrated that bone marrow derived proangiogenic cells are acutely mobilized following certain chemotherapy treatments, accompanied by enhanced tumor angiogenesis, which can be blocked by prior treatment with antiangiogenic drugs. These findings indicate that unknown host-derived mechanisms induced by chemotherapy, can stimulate tumor growth. Since the efficacy of antiangiogenic drugs is dependent on several parameters such as tumor type, stage, and the type of chemotherapy, such a therapy is not beneficial for all patients, and thus, necessitates the identification of surrogate biomarkers to predict clinical outcome. To address this issue, we will integrate basic, translational, and clinical approaches to:(i) identify molecular and cellular host systemic responses following treatments;(ii) isolate novel factors by proteomic approaches which are altered during the course of the treatment, and evaluate their feasibility as biomarkers to predict clinical outcome;(iii) determine the relevance of these factors in clinical specimens;(iv) screen for therapeutic compounds which can block host responses mediating tumor growth in order to increase treatment efficacy.We believe that this strategy of combined approach will lead to the development of new tools in clinical oncology. Profiling individual host response to anti-cancer drug treatment may serve as a biomarker for treatment outcome and further promote the concept of personalised medicine in cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tracing epigenetic evolution of triple-negative breast cancer towards chemo-resistance' (ChromTrace), addressing dissemination and exploitation.

assistant: **Impact**

The emergence of resistance to chemotherapy and targeted therapies is a major challenge for the treatment of cancer. While several genetic mechanisms driving resistance processes have been discovered, non-genetic mechanisms have also been shown to contribute to drug resistance. Yet, our restricted understanding of epigenetic evolution has so far limited our ability to modulate resistance using epigenetic modifiers. With ChromTrace, our goal is to reconstruct and define the contribution of epigenetic evolution to chemo-resistance in triple-negative breast tumors. In this aggressive sub-type of breast cancer, chemotherapy is the standard of care, but chemo-resistance remains the major unmet clinical need. We will explore the heterogeneity of H3K27me3chromatin states - key determinant of cell identity - in tumor cells, study how they are transmitted and determine whether they are associated to the resistance phenotype. Combining lineage tracing and targeted sequencing to our original single-cell chromatin profiling approach, we will reconstruct the dynamics of chromatin features over time in the context of genetic evolution. In parallel, using a live-cell microscopy reporter system, we will evaluate the association of recurrent chromatin features with the resistance phenotype and elucidate mechanisms of epigenetic tumor evolution. Our results on the heritability and plasticity of chromatin landscapes will have strong impact on our understanding of epigenetic evolution in cancer. Our long-term goal is to build on this integrated appreciation of molecular tumor evolution processes to propose novel therapeutic strategies to control resistance to chemotherapy. Finally, our approaches being applicable to any dynamic biological system, ChromTrace opens the perspective to study e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Transnational collaboration within the EU for research in high precision engineering, micro-engineering and nanotechnology - incorporating the formation of the European Society for Precision Engineering and Nanotechnology'.

assistant: **Objectives**

The Euspen society, established as a consequence of the Euspen EC project, has built the technological network and the business policies to pursue the on-going objectives of the project into the future. These objectives are primarily to promote and improve international competitiveness of European industry in high precision engineering, micro-engineering, nanoscience and nanotechnology. Project tasks planned included the formation of a society membership, the organization of seminars, conferences and scientific training, the stimulation of new EC collaborative projects and building strong relationships with other European and International networks and societies.In relation to the formation of the society Euspen (the European society for precision engineering and nanotechnology), membership was opened within the first year and now has more corporate members than any other technical comparable society on an international scale. The official structure of the society contains the headquarters, presently located within the UK, three regional centres in France, Germany and Italy, national nodes that are established in 8 further nations and then its membership. Strong relationships have been built with European corporate members. Numerous company visits have taken place and as a result, a large proportion of the training now provided by Euspen uses tutors from high-profile manufacturing organizations, such as Philips, Heidenhain and ASML.Successful International Conferences have taken place in Bremen, Copenhagen and Turin, whilst preparations are well underway for future events that will be held in Eindhoven, May 2002, Aachen, May 2003 and Glasgow, May 2004.In order to expand Euspen's portfolio of services, four EC proposals were submitted over the final project year includin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Functionalized carbon-supported Au Nanoparticles for Selective Oxidation Catalysis'.

assistant: **Innovation**

Oxidation of alcohols is one of the key reactions in the fine chemicals industry and is crucial for the conversion of biomass into valuable chemicals. Au catalysts demonstrate promising activity and selectivity in the aerobic oxidation of alcohols, however, they require addition of bases to operate at low temperatures, and often suffer from deactivation due to particle growth. Here I propose a strategy to circumvent these issues: employing Au catalysts supported on carbon materials with introduced basic surface groups. I will prepare and characterize a series of basic and novel “super-basic” carbon materials. Colloidally prepared gold nanoparticles will be deposited onto these supports, and the resulting catalysts will be tested for the selective oxidation of two relevant types of alcohols. Key will be the use of advanced characterization techniques to understand how the basic surface groups on the carbon affect the activity, selectivity and stability of Au catalysts in alcohol oxidation. I will address parameters such as changes in surface properties, shape and electronic properties of the Au nanoparticles, and changes in the adsorption strength of reactants, intermediates and products as a result of the different carbon surface functionalizations. The outcomes of this project will advance our understanding of the properties of Au nanoparticles supported on functionalized carbon materials, and in a broader sense generate insight into metal-support effects in catalysis, and hence facilitate the rational design of supported metal catalysts. Furthermore, this project will allow me to strengthen and expand my skills and expertise in the field of catalysis and materials chemistry, build professional network and establish my position as a researcher in Europe, which will hel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Co-ordination action on human rights violations'.

assistant: **Objectives**

The Co-ordination Action on Human Rights Violation (CAHRV) has selected interpersonal violence as its main theme. Violence against women is recognized as a serious challenge to democracy and social cohesion; this awareness now needs to be extended to t he victimisation of men, children, elders or socially vulnerable groups. Each act of violence may generate a cascade of further problems.Undeterred victimization detracts from other basic rights: for example, sexual abuse is a hidden cause of poor healt h, domestic intimidation restricts access to social participation, bullying negates the right to education. The field of interpersonal violence typifies fragmentation in addressing human rights violations. Each type of violation and setting has been see n as a distinct concern, research and actions look either at child abuse or at racist youth violence, at domestic violence or at trafficking. Theoretical and practical links between the different aspects of violence have been neglected. CAHRV will devel op methods to account for and overcome fragmentation in research, policy and practice. It will build on networks for women, children and men established under Frameworks IV and V, under the DAPHNE and STOP programs and on the work of experts for the C ouncil of Europe, and will identify and co-operate with sites of excellence.CAHRV opens up new perspectives by integrating research across gender and generational divisions, connecting these with aspects of citizenship and governance, including security, civic participation, knowledge based society and work. There are four sub-networks: identifying and profiling victims, understanding men's violence and gendered practices, addressing human rights violations,protective environmental factors. Each examine s when policies and inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Liquid Crystals in Flow: A New Era in Sensing and Diagnostics' (LCFlow) targeting Horizon Europe.

assistant: **Abstract**

Liquid crystals (LCs) are the delicate phases of matter that exhibit molecular order, fluidic nature and birefringent optical properties. LCs have been developed as materials suitable for energy- and label-free reporting of the chemical changes occurring at their interfaces such as the presence of biomolecular, gaseous or nano-/microscopic species, or the occurrence of the chemical or biochemical interactions/reactions involving these species. LC-water interfaces were employed in most promising sensors as a medium to facilitate the interaction of the LCs with the species. Although promising, the studies reported were limited to the stagnant LC systems, limiting their use in continuous sensing and diagnostic applications. This project is designed to open a new era in the sensing and diagnostic systems involving the use of LCs by introducing a microfluidic flow. The system of interest differs significantly from their counterparts with the introduction of LC-water interfaces that facilitates the exchange of analytical species during flow. However, the design of such system is challenging and critical understanding is required to proceed towards the next generation LCFlow platforms. We aim to design highly sensitive, dynamically tunable, and label-free LC based fluidic sensing platforms and therefore this proposal is structured to understand: 1) The effect of the presence of the ""soft"" interfaces and the LC interfacial anchoring on the flow regimes, and the LC director profiles, 2) The role of the type, scale, shape and the symmetry of the chemical heterogeneity at the contacting surfaces on the LC flow and configurations, 3) The dynamic influences of the changes occurring at the contact interfaces on the configuration and the optical appearance of the LC medium. The prop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Co-firing of bio-oil with simultaneous SOx and NOx reduction' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

This project aims at the direct injection of calcium-enriched bio-oil (BioLime) into the post combustion section of, typically, a 10 MWe power plant, in order to desulphurize the flue gas below today's regulations.Specific objectives are to:- demonstrate the technique of co-firing of heavy fuel oil and BioLime at 2 Mwth;- demonstrate 90% sulphur oxides (SOx) removal by applying BioLime;- demonstrate 50% nitric oxides (NOx) removal by applying BioLime;- demonstrate reduced CO2 output resulting from cofiring of the biomass derived BioLime;- develop an optimal bio-oil modification technology (maximum calcium uptake capacity);- determine the influence of biomass type (wood, straw) on the eventual BioLime quality;- demonstrate that the ash characteristics remain unchanged upon co-firing of straw-derived BioLime;- characterize the combustion process and emissions by monitoring concentration and temperature fields;- develop a mathematical model which describes the effects of BioLime injection on SOx/NOx emissions and predicts the optimal operating parameters.Technical approach Recently, organic calcium salts like calcium acetate, calcium magnesium acetate and calcium benzoate have been shown to simultaneously reduce SOx and NOx emissions at elevated temperatures, typical of coal and heavy fuel oil combustors, at considerably lower Ca/S ratio's than in the current practice of in-situ desulphurization (1.1:1 instead of 3:1). Biomass pyrolysis liquors offer a low cost feedstock for the preparation of such organic calcium salts. Bio-oil can easily be obtained by rapid heating of any kind of biomass in absence of oxygen, whereby subsequent condensation of the product vapours yields 70 wt% bio-oil. This bio-oil is then modified by adding lime Ca(OH)2 to yield the sorbent  BioLime" w