RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards increased diagnostic sensitivity by assay miniaturisation' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Within this project research will be performed at KREATECH Biotechnology B.V ., at the Department of Molecular Cell Biology of the Leiden University Medical Center (LUMC), and at the Department of Applied Physics of the Delft University of Technology (TU Delft). All laboratories are (scientifically) highly skilled, modem, and with state-of-the-art equipment. KREATECH is a biotechnology industrial organization with patents on the Universal Linkage System (ULS^R) and Mycobacterium diagnostics (ABC). KREATECH has broad knowledge of the biochemical and biological properties of ULS^R and on the development and production of biochemicals and diagnostical based on these patents. LUMC is highly skilled and experienced (amongst others) in the in-vitro (molecular) detection of biomolecules and (more recently) in the development of micro array technology. The TU Delft is highly skilled and experienced (amongst others) in the development of (nano-litre scale) biosensor technology. All institutes are (inter)nationally highly acknowledged and have extended (scientific) networks, both national and international. Moreover, all institutes have vast experience in guiding and teaching fellows at all scientific levels. In this project research is proposed to significantly increase diagnostic assay sensitivity up to a factor of 100.000 (10^5), both for nucleic acids and proteins. This problem will be tackled at:1) the level of the detection format,1a) by miniaturization ('from ELISA/dot blot- via micro array- to biosensor format'), and1b) by optimization of biomolecule - ULS^R- solid support binding, and2) the level of sample processing (by a direct ULS^R 'target labeling' technology).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structure-function analysis of the calcium channel TRPV5' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Ion channels are proteins composed of a hydrophillic pore that facilitate ion flow across a plasma membrane. This ionic permeability is controlled by a set of essential properties affecting the channel activation and inactivation in response to voltage, ligands, or intracellular second messengers. The focus of the present project proposal, the transient receptor potential vanilloid channel (TRPV5), forms a specific category within the large TRP familiy of ion channels as it comprises a unique high selectivity for calcium ions together with a calcium-dependent inactivation mechanism that is incompletely understood. Detailed analysis of the TRPV5 channel will provide new structural insights into channel gating that can be extrapolated to other TRP channels, as the current knowledge on the TRP protein structure and its impact on the regulation of the channel function is still limited. The key objective of my project is to deliver the first detailed mechanistic view of TRPV5 by connecting Prof. Cheng’s expertise in structural biology with my biophysical background on TRP channel functioning. The following work packages will be addressed:1) Channel activation mechanism of TRPV5Elucidation of the 3D structure of integral TRPV5 by single-particle cryo-EM will provide critical structural and mechanistic insight into calcium-dependent regulation of channel function.2) Intramolecular regulation of TRPV5Reconstitution of TRPV5 into lipid nanodiscs and liposomes allows detailed study on lipid regulation and the mechanism of channel inactivationTaken together, this project focuses on the structure-function analysis of TRPV5, a distinctive calcium-selective TRP channel. The goal is to elucidate the structure of the TRPV5 channel, and to unravel functional domains that are involved in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Freshness and expiration date measurement'.

assistant: **Objectives**

20% of all meat and 35% of all fish produced is wasted, and being the most resource consuming food to produce, a reduction of this type of waste will have significant environmental impact. In the EU the yearly meat and fish waste corresponds to a CO2-equivalent emission of 193 mio tonnes and has a value of 41 bil €. By reducing the amount of wasted meat and fish due to incorrect or overcautious shelf-life estimates, for which the effect is transmitted through the value chain, the EU CO2e emission could be reduced by 80 mio tonnes and save the industry 4,75 mio tonnes equal to 17 bil €. AmiNIC is a Danish SME, developing and commercializing a handheld patented sensor-technology for determination of freshness and prediction of shelf-life for meat and fish. The device could be considered an intelligent nose, 1000 times more sensitive than the human nose, and from database values, forecast the precise and correct expiration date. The nozzle of the handheld device, in hygienic design, is pressed against the surface of the meat or fish and measures, within seconds, the concentration of degradation molecules in the meat and thereby the freshness. Prediction of expiration date is accomplished by forecast curves for the development of that particular piece of meat or fish.In contrast to the human senses this device gives a measurable value for freshness and is able to predict expiration dates. In comparison to 48 hours microbiological analysis, which can also determine freshness, use of our device does not require trained personal, it is cheap and can be used on-location and gives result immediately, including prediction of shelf-life.The device is initially targeted at the intermediate part of the value chain of meat and fish; processing, distribution, mongers, supermarkets, re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Genetics of Morbidity and Survival in Response to Significant Life Stressors' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Significant life stressors – including death of loved ones, being diagnosed with a life-threatening illness, and exposure to natural disasters or violence – are well-documented risk factors of ill health, disability and premature mortality. Why some individuals remain healthy while others remiss to adverse symptoms, disease or death after exposure to such life stressors remains unclear. The overarching aim of this research program is to advance current understanding of the potential genetic contribution to varying trajectories of health following exposure to significant life stressors. The program leverages the registries of major diseases and mortality covering the whole Icelandic nation (N=330.000) and the unique genetic- and genealogical resources at deCODE Genetics to perform genome-wide association studies (GWAS) on the varying risks of overall mortality and major diseases (including psychiatric disorders and cardiovascular disease) after loss of a family member or after receiving a cancer diagnosis. We will further seek to identify sequence variants associated with variation in symptoms of posttraumatic stress disorder (PTSD) in two highly traumatized cohorts: the SAGA cohort of 30.000 Icelandic women with high lifetime prevalence of violence exposure, as well as a cohort of 5.000 Swedes exposed to the 2004 SA-Asian Tsunami. This research program represents the first major attempt to address the potential genetic basis of varying somatic health outcomes after exposure to significant life stressors and, to our knowledge, one of the first comprehensive GWAS on PTSD in European populations. Virtually everyone is at some point in their life exposed to significant life stressors or trauma; the knowledge gained from this comprehensive research program may facilitate ear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated Marine Pollution Risk assessment and Emergency management Support Service In ports and coastal enVironmEnts' (IMPRESSIVE).

assistant: **Innovation**

IMPRESSIVE project focuses in developing a universal-relocatable platform for real time management of marine pollution events in the wider area of EU harbors and their vicinities, easy to manipulate and use from the harbor control post. EO monitoring and advanced modeling of these areas are of great interest as the large ship activity, ship traffic and ship refueling, addresses them as highly risky for pollutant spills and waste waters. The product will be consisting of integrated operational services relying on:* A satellite monitoring service processing Sentinel 1, 2, 3 satellite images and Copernicus Marine products to identify polluting events (oil spills and waste water discharges), to generate alerts and provide their position and features in near real time.* A software package that once an event is located will provide forecast of its drift and fate, based on coupling between the pollutant fate and transport and the hydrodynamic numerical models, supporting decision making and the maneuvering of the autonomous vehicles with advanced positioning technologies.* A set of risk mapping services based on the integration of time series of remote sensing and modeling products.* A set of specifically designed Autonomous Surface Vehicle (ASV) and a drone (UAV) equipped with remote sensing instruments and a sampler device (on board of the ASV), remotely operated from the Headquarter Control Post for operational monitoring missions and/or accidental/illegal oil spills and other polluting events.* A local rapid-response integrated system of near real time satellite/ASV/drone/model/forecast/risk mapping survey information and products, to support/improve the decision making process in any particular spilling event that may occur inside or outside the harbor or in near coastal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Trade the the Environment: Policy Research Needs (With Emphasis on Agriculture)' under Fifth Framework.

assistant: **Concept**

The objective of the proposal is to set regional and topics priorities for international co-operation with developing countries on the agricultural trade and environment issue , providing a forum for the discussion and exchange of ideas regarding future policy research needs in such a field. The format of the workshop will encourage participants to pursue the following specific objectives: a) think creatively about what factors will have the greatest impact on trade, environment and agriculture in the next 10-20 years; b) highlight the steps and the research needs to develop a strategy that outlines actions to achieve by the year 2020 world with freer, less distorted and more equitable trade, and, at the same time, a better preserved environment. The expected output of the workshop are concept notes for joint proposals addressing various aspects of the trade-environment issue for the year 2000 INCO Calls.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Rabbinic Literature in Moravia from the Fifteenth to the Nineteenth Century' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Rabbinic literature is an important genre of primary sources of Jewish cultural, religious, social, and intellectual history. As a rule rabbinic texts were written by the rabbis who formed the intellectual elite of traditional Judaism. Rabbinic texts are often difficult to understand; nonetheless, researching them is quite rewarding. Besides providing many “hard facts” about the life of Jewish communities rabbinic texts also inform modern researchers about how reality was perceived by the intellectual elite of the Jewish minorities and they reveal the possibilities and limits of a religious authority that functioned for the most part of its long and complex history under the dire conditions of discriminated minority. The Jewish community of Moravia (a region in the Czech Republic) played a very important role in the Jewish life of the pre-modern period from the sixteenth until the nineteenth century. It was close to such important centers of Jewish life as Vienna, Prague, Bratislava, and Budapest. The Moravian chief-rabbi (Landesrabbiner) was one of the most prestigious rabbinic positions in Europe. The rabbinic literature produced in the region is an eminent source-material about the social and intellectual history of Moravian Jews and extremely important from a comparative perspective as well. In spite of its importance, the history of the Jewish communities in Moravia has received little attention since the Holocaust period. This is true even more of the rabbinic literature written by or about Moravian Jews. The research project proposed here aims to realize this desideratum by (1) surveying the rabbinic sources that were produced in Moravia or about Jews living in Moravia from the fifteenth to the nineteenth century; (2) preparing an annotated bibliography of these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Agent-based theorem proving' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

In this project we transfer and apply multi-agent techniques to automated theorem proving. The goal is to achieve more flexible organization of heterogeneous reasoning techniques within a theorem-prover to provide a better approximation of human reasoning and to solve more complex problems. For this we will investigate several topics. -Distributed Proof Search: We have to examine possible dependencies between parallel proof attempts I how backtracking can be organized and how a final proof object can be reconstructed. -Resources: Appropriate resource concepts have to be identified to keep proof search tractable. -Flexible Cooperation: This is achieved by dynamic formation of clusters of reasoning agents to either cooperatively or concurrently solve problems. The concise communication of partial proofs between agents is essential to keep communication time low. -Architecture for Reasoning Agents : The reasoning agents need to be embedded into an agent architecture that allows them to recognize their own abilities and those of other agents in order to negotiate about forming clusters and resource allocation. After modeling an appropriate system architecture we plan to implement the working system and to test our concepts with a case study to experiment both with the theorem proving aspects as well as the multi-agent aspects of the system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Development of a new therapeutic product targeting neuroimmune circuits to treat asthma'.

assistant: **Innovation**

Asthma affects approximately 3% of the population and results in 1,000 daily deaths. It is characterized by chronic lung inflammation and airway hyperresponsiveness. First lines of treatment have not evolved in the last decades and actual developments are essentially focusing on severe asthma management (7% of patients) via the targeting of inflammatory mediators. Unfortunately, 60% of asthmatics still suffer from uncontrolled symptoms.The lungs are innervated by peripheral neurons expressing specific sets of G protein-coupled receptors (GPCR) that contribute to bronchoconstriction and regulate allergic immune response. Among the broad family of GPCRs, the GPCRX has never been studied in a pathological context, albeit human and murine orthologs share a remarkable sequence identity. We have created a new transgenic mouse, GPCRXMut, allowing both to track the receptor expression and to interrogate its function in vivo. The GPCRXMut mouse exhibits normal immune and sensory systems at steady state. Our data demonstrate that a) GPCRX is expressed by both peripheral neurons and certain lung-resident immune cells; b) the selective invalidation of GPCRX completely protects against the development of asthma in various models; and c) lung biopsies from asthmatic patients show high expression of GPCRX in neurons and immune cells.The ERC proof of concept project IMMCEPTION 2 aims to develop a selective antagonist for GPCRX to treat asthmatic patients. We will 1) miniaturize our established screening system for antagonists; 2) identify leads capable of specifically blocking GPCRX; and 3) develop a new mouse model humanized for the GPCRX to further validate identified leads in vivo. The research program has been carefully designed to leverage our expertise in neurobiology, immunology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Network of Knowledge Transfer in Health' (ENTENTE) under Seventh Framework.

assistant: **Objectives**

The objective the ENTENTE project is to reinforce knowledge transfer (KT) offices in universities, public research organisations, hospitals and to promote industry academia transnational collaboration in the health sector. This will be achieved through seven sub-objectives:1-The development of a web platform for shared learning and networking including best practices, video interviews, networking and e-learning modules for scientists, hospitals, program managers and policy makers, enabling continuous updating on innovative measures and interactive networking among all type of actors.2-The continuous identification and promotion of good knowledge management and KT practices in the EU MS and AC, providing evidence on best practices including standardisation and key components for running a successful KT organisation.3-Give visibility to best achievements at the EU level, including impact of legislation and tax incentives on technology transfer and innovative SMEs, as well as good KT from EU-funded projects.4-The development an online repository of best practices in KT, included in the web platform and built on existing repositories. Its active promotion will be secured through the events that will be organised during the project.5-The promotion of interaction between universities, industry, investors and individual researchers with the organisation of workshops, partnering events and staff exchanges, between different types of actors.6-The organisation of national activities, based on the activities of ASTP.7-The organisation of two ENTENTE events during the project lifetime in Brussels and elsewhere in Europe engaging all stakeholders at large, including the DG R&I promoting collaboration and exchanges with the industrial tissue.The main result of the ENTENTE project wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SUMOrice: Exploiting an emerging protein modification system, SUMOylation to boost rice yield during drought and salt stress' (SUMORICE) under Seventh Framework.

assistant: **Objectives**

To feed 9 billion people by 2050 is an unprecedented challenge. Rice is the food source for the majority of the world's population but also a model for cereals. Drought and related high salinity during essential periods of plant growth affects nearly all crops including the major cereals such as rice causing drastic yield losses. A major goal of plant biology is to develop crop cultivars that are ""drought and salt resistant"", defined as those that have higher yields than standard cultivars under these environmental stresses. However plant responses to drought and salinity are overlapping and complex involving many physiological pathways controlled by cascades of molecular networks. This makes engineering drought and salt resistance in crops possible but very challenging unless we identify molecular mechanisms (‘Master’ co-ordinators) that can influence multiple signalling networks to produce an integrated stress response. Crop improvement programmes that target these ‘Master’ co-ordinators will have the greatest potential for yield increase.We have discovered that SUMOylation, an emerging protein modification mechanism can be recruited to co-ordinate multiple molecular response pathways to dramatically improve plant growth on high salinity and during drought stress. This groundbreaking and exclusive discovery ideally places us to exploit this finding to generate stress resistant crops. SUMOrice is a pioneering interdisciplinary proposal that uses an innovative approach to produce novel alleles of genes regulating multiple stress signaling cascades. To achieve this we will use an unconventional blend of 2 platform technologies (SUMO proteomics, ecoTILLING) to produce drought and high salt resistant rice. SUMOrice is 5-year project that brings together a team of 4 scien