RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'LAntibiotic Production: Technology, Optimization and improved Process'.

assistant: **Innovation**

The focus of this proposal is to develop an economically viable production process for the lantibiotic NAI-107, a new antibiotic with the potential to treat life-threatening infections caused by multidrug-resistant Gram-positive pathogens. NAI-107 is produced by fermentation of the actinomycete Microbispora sp., is undergoing formal toxicology studies and is expected to enter Phase I clinical trials in the second half of 2009. NAICONS, an SME participating in the project and acting as coordinator, is developing NAI-107. A challenge in advancing a new antibiotic into clinical development is to devise a production process that will deliver a high quality compound at reasonable yields. This is particularly relevant for NAI-107 since no lantibiotics are industrially produced as drugs for human use and there are no examples of industrial use of Microbispora. The development of a robust and economically feasible production process for NAI-107 requires the integration of basic knowledge of the physiology of the strain which can be best obtained by a combination of classical and post-genomic approaches (proteome/transcriptome), with a detailed knowledge of the production process and its scalability to industrial level. This will be achieved by flux analyses and 2D-maps for discovering primary metabolism proteins up-regulated during antibiotic production. Combined with a study of other limiting steps, such as precursor uptake, product excretion and the intrinsic resistance of the producing strain, and with analysis of the transcriptional regulation of the NAI-107 biosynthetic genes, bottlenecks in production will be identified and bypassed by metabolic engineering leading to an optimized metabolic pathway for the production of this life-saving antibiotic and an efficient product
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sputtering Halide Perovskites for Integration in Monolithic Tandem Solar Cells' to be submitted under Horizon Europe.

assistant: **Abstract**

Perovskite-silicon tandem solar cells are one of the most promising new technologies in solar energy research, due to their high efficiencies and use of low-cost materials. One attractive way to make these tandems is to grow the wide band gap perovskite on textured silicon solar cells, forming a monolithic tandem. Record efficiencies of 31.25% have been reported for these monolithic tandems, but still on relatively small area devices (1 cm2). To bring this technology closer to the market, it is imperative to start focussing on scalability. Specifically, the perovskite top cell needs to be reliably produced with industrially-validated, scalable deposition methods. This deposition method should also allow high deposition rates and direct integration of the perovskite top cell into textured silicon cells. SPRINT will develop sputtering deposition of these perovskites. Sputtering is a highly industrialized physical vapor deposition (PVD) method that tackles all challenges: high deposition rate, conformal deposition and is scalable. But to date it hasn’t been explored for halide perovskites. SPRINT's goal is to use the knowledge generated in my ERC StG CREATE for halide target fabrication (patent filed) and single target PVD deposition, and apply this to develop a sputtering coating process for inorganic wide band gap perovskites for monolithic integration in tandem devices. SPRINT will bring an innovative solution to key stakeholders in the PV market. Specifically, PV module manufacturers (such as Oxford PV and Meyer Burger) could implement the process into existing sputtering systems in their R&D labs and later into production lines. Vacuum equipment manufacturers (such as Von Ardenne and Demcon TSST) will benefit from the demand for deposition equipment. This will allow f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Integration of Novel Aerospace Technologies'.

assistant: **Innovation**

INNOVATIVE will enable the systematic integration of novel aerospace technologies through the training of 24 researchers through a comprehensive multidisciplinary programme. INNOVATIVE is about the exploration of game-changing and disruptive technologies, materials, methods and processes for the aerospace sector AND their impact and interactions in the context of the virtuous pyramid of interdependences (in aerospace) spanning weight, cost, energy and the environment, and the human experience and safety.INNOVATIVE will aim to deliver a step-change in the training of Early Stage Researchers (ESRs) in aerospace technologies by providing a comprehensive programme that will empower these researchers with a multidisciplinary skillset comprising tools, techniques and methods suitable for pursuing careers in Aerospace Technology and related fields.Flightpath 2050  sets out a vision for a future aerospace industry with “A network of multidisciplinary technology clusters” being at the heart of technology development to keep Europe competitive in this strategically important global industry. The programme has been specifically designed to meet the future skills needs of the aerospace industry, but is applicable to a wide range of industry sectors where traditional disciplinary boundaries need to be eroded and replaced with multidisciplinary skills. The individual researcher trained through this programme will have a novel skillset that separates them from their competitors and will be attractive to take up high-powered roles in industry, where they can nurture teams with a mindset that allows for multidisciplinary thinking and systems thinking.


**Keywords:** aerospace, aero-engines, airframes, power electronics and electrical systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Coordination Action for Research Activities on Life in Extreme Environments', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Life in Extreme Environments (LEXEN) is an emerging area of research in which Europe has considerable expertise but a relatively fragmented research infrastructure.  The science of such environments has enormous relevance for our knowledge of the diversity and environmental limits of microbial, plant and animal life and the novel strategies employed for survival and growth.  Such studies are essential in understanding how life established on the early Earth and in assessing the possibilities for life on other planetary bodies. These environments are also a rich source of novel exploitable compounds.    The Work Programme identifies a need for better coordination of LEXEN research and CAREX aims to address this need by developing a clearly identifiable, dynamic and durable community.  Establishing this community will encourage greater inter-disciplinarity and increasing knowledge of extreme environments.  It will provide a target for young career scientists and allow a more focussed dialogue with other science areas, with funding agencies, with industrial groups and with international organisations outside Europe.   CAREX deliverables will include a strategic roadmap for European LEXEN research (including enabling technologies), diverse opportunities for knowledge transfer, standardisation of methodologies, encouragement and support for early career scientists and a network of links to relevant organisations.   These deliverables together with improved community networking, supported by newsletters, promotional leaflets, a series science publications and an interactive web portal, will help consolidate the community and its identity.   Outcomes will be facilitated through science/technology workshops, diverse forums, field/laboratory protocol intercomparisons, a summer s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ratiometric FRET Based Nanosensors for Trypsin Related Human Recessive Diseases' (2-NanoSi), addressing dissemination and exploitation.

assistant: **Impact**

The project aims to create a demo system for cost effective, non-invasive device for rapid detection of cystic fibrosis inhumans.The detection of human recessive diseases has been dominated by the use of fluorescent biomarkers, based on organicdyes, helping researchers to study and analyse gene expression, cell cycle, and enzymatic activity. Among severalproteolytic enzymes, trypsin has attracted much attention, as it is a target in the study of various important human recessivediseases including, for example, cystic fibrosis (CF).We present herein two colour encoded silica nanospheres (2nanoSi) for the fluorescence quantitative ratiometricdetermination of cystic in humans. Current detection technologies for cystic fibrosis diagnosis are slow, costly and sufferfrom false positives. The 2nanoSi proved to be a fast (minutes), a single-step and with two times higher sensitivity than thestate-of-the-art biomarkers based sensors for cystic fibrosis, allowing the quantification of trypsin concentrations in a widerange (25-350 μg/L). Moreover, our approach can be used from the 4th day of life when the trypsin concentration is alreadythe same as in adults. Furthermore, as trypsin is directly related to the development of cystic fibrosis (CF), different humanphenotypes, i.e. normal (160-340 μg/L), CF homozygotic (0-90 μg/L), and CF heterozygotic (91-349 μg/L), respectively, canbe determined using our 2nanoSi nanospheres. We anticipate the 2nanoSi system to be a starting point for non-invasive,easy-to-use and cost effective ratiometric fluorescence biomarker for recessive genetic diseases alike human cystic fibrosis.


**Keywords:** Nanomedicine, health, nanomaterials, cistic fibrosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of high-speed processing quick-test for the evaluation of honey quality' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The quality of honey from non-European countries, e.g. from china, is often insufficient. Currently, scientific experts determine the quality of honey with complicated methods in sate-of-the art laboratories. Hence, quality control of honey is not totally under the control of sees dealing with honey. It is the main intention of the proposed project to develop simple quick-tests for the rapid determination of quality parameters in honey. This could include the quick determining of ingredients of honey that could be used as quality indicators and as suitable targets for the development of quick-tests. Research is needed in order to simplify the currently available laboratory procedures. Simplification should lead to the development of strips, simple proof-solutions etc., usable as quick-tests. The development of quick-tests would be of great advantage for the sees involved in the honey business since they are no longer totally dependent on the work of scientific experts but they will be able to check quickly quality parameters of honey their self. This could be performed also onsite, i.e. in the honey producing countries (china, Argentina, etc.)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A computational study of the interaction between nanoplastic and model biological membranes' under Seventh Framework.

assistant: **Concept**

Every year, millions of tons of plastic litter are reversed into the oceans, washed up on the shores or piled in landfills. There, plastics are degraded down to the micro and nano scale, and enter the food chain. Plastic particles can transport toxic substances, but the effects of micro and nanoplastics themselves on living organisms is still largely unknown.Here we address a key step of this interaction: the interaction of nanoplastics with model biological membranes. We propose a computational study of the interaction between polymers of everyday use and model lipid membranes. Our main goal is to identify possible physical mechanisms of damage to the cell membrane induced by the interaction with plastic nanofragments.Membranes can be altered in many ways: mechanical (membrane rigidity), dynamical (lipid and peptide diffusion) and structural (lipid order, area per lipid, membrane thickness). Even more interestingly, our preliminary results show that hydrophobic polymers such as polystyrene can influence the lateral organization of heterogeneous lipid membranes into ordered (rafts) and disordered domains. These changes are relevant as they can affect the functionality of membrane proteins and other constituents, therefore altering the overall cell functioning.We will study the polymers most commonly found in the marine environment (polypropylene, polyethylene, polyethylene terephthalate, polystyrene…) and model membranes of various compositions. We will model both the polymers and the membranes at a coarse-grained level, relying on the support of detailed all-atom models whenever necessary.Characterizing the interaction of plastic nanoparticles with cell membranes is the first step towards understanding the physical and chemical basis for their toxicity in all living or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Connecting Joint Function to Chondrocyte Biology in Knee Osteoarthritis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Osteoarthritis (OA), a degenerative joint disease, debilitates the lives of 242 million people globally but remains without a cure.The knee joint is most frequently affected, causing pain, loss of joint function, and reduced quality of life. OA-CONNECTinstigates an innovative approach to understanding the fundamental cause of OA by posing a question that could previouslynever be answered: ‘What causes mechanical loads to switch from supporting to disrupting cartilage health in OA?’OA-CONNECT introduces a unique, integrated approach CONNECT-ing joint function to chondrocyte biology to unravelthe OA Mechanome, the maladaptive dynamic interplay of mechanical and biological drivers of OA cartilage degenerationacross cellular-, tissue- and joint- scales by:(1) Connecting the spatial mechanical and cell molecular dynamics underlying OA cartilage adaptation to loading, using multimodalread-outs from spatial omics, functional microscopy, and high-field MRI.(2) Predicting cartilage degeneration by connecting knee joint cartilage loads during movement to local cellular mechanobiologicalprocesses, using a multi-scale mechanobiology-inspired adaptive modeling framework informed by datasets of (1).(3) Elucidating cartilage degeneration probability and mechanotherapy success in subjects with early knee OA, integrating themulti-scale model of (2) with machine learning, multi-variate and population-based methods leveraging the use of clinicallyaccessible ‘real-world’ data. Prospective cohort and proof-of-concept studies will capture the dynamics of mechanical andbiological drivers and the impact of three current mechanotherapies.The field of OA needs a shift in focus as the approaches of the past 20 years could not bring the mechanistic insights requiredto develop treatment strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Induction based Curing Tool for Optimized heating of composite Repairs' (INDUCTOR).

assistant: **Concept**

Appropriate curing of the patch resin and the adhesive layer is an essential step to secure the integrity and the sound mechanical performance of bonded composite repairs. Today, the required temperature elevation is achieved by means of resistance heating blankets, conducting heat to the repair area. This method is simple and works adequately for small repairs, but when larger areas need to be heated, discrepancies, like cold or hot spots, occur, due to variable heat losses, caused by “heat sinks”. The scope of this proposal is to change the currently used heat generation principle, from conduction to induction heating for large repair cases (i.e. 65x65cm or larger). Heat will be generated within the repair by induced electrical currents (eddy currents) through a coil placed on top of the patch, creating an alternating electromagnetic field to the conductive elements of the repair (susceptors). The system is made of several flexible coils, driven by induction equipment employing multi-channel temperature control, to compensate for differences in temperature development across the structure. The process will be monitored by special software, capable of compensating temperature differences by variable heat generation algorithm. The susceptor will be one or a combination of the following elements: a) the lightning protection metallic mesh placed on top of composite repairs, b) the carbon fibers of the patch and surrounding structure, c) a special metallic mesh embedded into a silicon mat, placed directly on top of the patch. The induction heating method will achieve better temperature homogeneity and process efficiency compared to conventional conduction heating equipment and methods, resulting in direct improvement of the repair quality. As induction heating is a non-con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Amazonian collaboration in strengthening research capacity to address regional and global implications of Amazonian deforestation and its contribution to global change' to be submitted under Fourth Framework.

assistant: **Abstract**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'European Researchers' Night in Sweden 2024_2025: ForskarFredag 2024_2025'.

assistant: **Objectives**

ForskarFredag (Researchers’ Friday) is Sweden’s most widely dispersed science festival. ForskarFredag 2024 and 2025 (FF2024_25) will consist of events arranged in 26 cities and an online programme, open to anyone. In total, FF2024_25 will engage around 53,600 attendees and 1150 researchers.The non-profit association VA (Public & Science) has coordinated FF annually since 2006. FF2024_25 builds on previous years, drawing on experience, contacts and an ever-increasing profile. The FF motto is ""Researchers are ordinary people with extraordinary jobs”.At FF2024_25, members of the public will meet researchers and participate in activities designed to stimulate dialogue and show that research is exciting and relevant to everyday life: debates, science cafes, competitions, shows, experiments and hands-on activities. Common themes around EU priorities will inspire activities exploring the role of research in tackling societal challenges. A collaboration with 7 other ERN projects will deliver a set of European-wide activities, highlighting the European dimension of research.Young people aged 6–19 are a key target group. A school programme will offer numerous opportunities for encounters with research. The “Borrow a Researcher” concept will enable 15,000 pupils across Sweden to meet a researcher in school or virtually as a “Researcher at Schools” initiative. Annual national mass experiments (citizen science projects) inviting pupils to work with researchers, will involve appr. 3000 people.Local events (physical and some digital) expected to reach around 35,600 attendees will be organised by 10 Partners and 18 External Partners. Each event builds on local strengths and networks to give the highest possible impact. All event organisers share experiences in a national network. VA i