RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrated Thermal Energy Reduction, Recovery & Re-use in Autoclave based Composites Processing'.

assistant: **Objectives**

Our Idea is to develop an integrated, computer controlled, heat recovery, reuse & thermal energy management system centred on the autoclave with re-use of thermal energy in the post-cure ovens or autoclaves, and possibly in the clean room air filtration/cooling system. The proposed system will extract heat from the autoclave to match existing cooling rates that are specified by material manufacturers. The heat will be stored in a specially designed thermal store at the highest enthalpy possible to maximise opportunities for re-use. We aim to reduce initial energy use in the autoclave by at least 25% through reduction of the autoclave headspace and recover 50% of the energy wasted at the end of the autoclave processing stage for re-use in other energy intensive heating processes such as the post cure process. In addition, we aim to recover compressed air (with its intrinsic compression energy and heat from the autoclave) and heat from the air compressors that create the 7 to 10 bar pressure and integrate this with the system.Our proposed technology would have a major impact on end-users and the environment. In summary we could achieve energy savings of 639,000 kWhr per system p.a; equating to €66,000 in end-user increased gross profit potential per system p.a. and would reduce CO2 emissions by 318 Tonnes p.a.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Emotion regulation in adolescents at risk for depression' to be submitted under Horizon 2020.

assistant: **Abstract**

This project will examine whether deficient emotion regulation (ER) in response to interpersonal events is a vulnerability factor for MDD First, we will examine whether, compared to controls, at-risk individuals (a) respond to criticism with higher negative affect (NA), greater activation in brain areas related to NA, and less activation in brain areas related to ER, and (b) respond to praise with lower positive affect (PA) and less activation in brain areas related to experiencing pleasure. Second, using experience sampling methods (ESM), we will examine whether, compared to controls, at-risk individuals (a) respond to negative interpersonal events with higher NA and deficient ER strategies, and (b) respond to positive interpersonal events with lower PA and deficient ER strategies. Then, we will examine whether neural activation in response to interpersonal stimuli in the lab predicts affective responses to everyday interpersonal experiences. Finally, gender differences will be assessed. The sample will include 50 children of mothers with a history of MDD and a control group of 50 children of never-disordered mothers. In the first lab visit participants will complete a diagnostic interview. In the second lab visit participants will complete questionnaires assessing depression and ER strategies,  an fMRI scan while listening to a recording of critical remark and praising remarks from one’s mother. Finally, they will receive training in the computerized experience-sampling diary. The diary electronic device will prompt participants 4 times a day for 14 days and will assess daily positive and negative interpersonal events, mood, and ER strategies. The examination of deficient ER in response to interpersonal events as a vulnerability factor for depression development is in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Regional innovation strategy for Pomerania region' in the context of a Sixth Framework call.

assistant: **Objectives**

At the end of 2004 there was finished the project: Basic Regional Innovation Strategy for Pomerania Region (RIS-P). The Strategy was approved by the Regional Parliament at December 2004.The Basic RIS-P project was financed domestically by the Polish Scientific Committee, Self-government of Pomorskie Voivodeship and other regional institutions involved. Now, the Basic RIS-P is being implemented by a project named: RIS-P Implementation Office (BW RIS-P). The focus of these initial projects has been relatively narrow and is therefore more akin to a traditional technology transfer strategy than the by now commonly accepted EU RIS methodology.Therefore the RIS process for Pomerania will add considerable value to strengthening innovation capacity in the region and will build on elements of previous work conducted through the work financed by the Polish Scientific Committee and the Self-government.The Regional Innovation Strategy for Pomerania region is an exciting initiative in that for the first time it will bring together all the key partners in the region, key partners from other EU regions and work together on a common framework for the region. This framework will not only enable the Pomerania region to increase its innovative capacity, but also provide quality input into the programming of structural fund programmes beyond 2007.The strategic objectives of the RISP project is to extend and upgrade the regional innovation strategy for the Pomerania Region in line with the EU RIS methodology and experience of partner regions and on these basis further develop the regional innovation system with the aim of supporting innovativeness, technology transfer and SMEs creation and functioning.Such a system should consist of the innovation and business support institutions spread ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Chemical and electrochemicalsynthesis of paramagnetic alkine complexes their applications in catalysis and organic synthesis' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content This proposal seeks support for a study of redox-generated alkyne radicals, particularly of the Group 6 metals, Co and Rh(II). The aims of this work are: -to synthesise a wide range of paramagnetic alkyne complexes -to exploit their chemical reactivity in stoichiometric and catalysed organometallic and organic synthesis -to devise clean and selective electrosyntheses based on alkyne radical as intermediates. -to initiate a study of aqueous organometallic electrochemistry. The new work will be based on complementary chemical and electrochemical studies. On basis of voltametry (giving the potentials at which the diamagnetic precursors are oxidised or reduced), methods forthe systematic generation (and isolation where possible) of the radicals will be devised. The potentials of substrate and chemical redox reagent will be matched on the basis of a recent compilation of data. Such radicals will also be generated electrolytically, at potentials chosen on the basis of voltammetry. The chemical reactivity of the radicals will be explored as outlined above. Throughout, all new species will be characterised spectroscopically (IR, NMR, etc.) and structurally X-ray structural and ESR spectroscopic studies of the paramagnetic complexes will be important in defining electronic structure. Where possible, reactive intermediates will be characterised by spectroelectrochemistry and the kinetics and mechanisms of radical reactions will be quantified by electrochemical methods. Training content (objective, benefit and expected impact) Electrochemistry may be used to gain mechanistic and quantitative informations on the reactivity of organometallic transient intermediates. These intermediates seem particularly suited to the study of electron transfer (ET) ca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'THE CENTRAL ROLE of THE UBIQUITIN PROTEASOME SYSTEM IN REGULATORY PROCESSES INVOLVED in IMMUNOLOGICAL, INFLAMMATORY, ENDOCRINOLOGICAL AND MALIGNANT DISORDERS'.

assistant: **Objectives**

The ubiquitin pathway plays a major role in regulated degradation of cellular proteins. It is involved in basic processes such as cell cycle educated scientists. During the four years of training, a comprehensive education will be provided via a three-stage program: the Network will hire regulation, tumour suppression, antigen presentation, regulation of young scientists immediately after their Ph.D. for a period of two years, apoptosis, and modulation of signal transduction. they will receive state-of the-art training in a research project using The objectives of the proposed project are to further elucidate the advanced facilities. Thereafter, they will be working in cooperative ubiquitin proteasome protein degradation system and to dissect the role of research projects (between partners). In total, six to ten post-doctoral the system in antigen presentation, regulation of cell cycle and degradation of growth and transcriptional regulators. Subsequently, it fellows will be educated. will be possible to identify potential targets for designed drug development in biomedicine and pharmaceutics. | The proposed Network brings together prominent European researchers in the field and will become a platform of international standard. Together the partners have at their disposal all modern facilities required for advanced biomedical research. Its composition and stature guarantees pioneering and innovative breakthroughs in the future. True collaboration and technology transfer are essential for their success.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Satellite hydrographic monitoring and assessment of environmental trends along the russian arctic coast', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

In this project the full potential of satellite remote sensing for coastal hydrographical monitoring In the Western Russian Arctic (WeRA) shall be evaluated and utilised. The goal is to support natural exploration, maritime operations and environmental protection with reliable up-to-date hydro graphic information in the form of a regional coastal reference database (RECORD). Emphasis is put on regional and local studies of hydro graphic regime, spatial changes of coastlines and environmental trends in the Barents and Kara seas. Specific questions related to pale geography, glaciology, geology, oceanology, coastal topography and geodesy will be considered as well. Results will be verified by using ground control and ground-truth data as well as by comparison with results achieved by other investigators.Deliverable No. Deliverable title.1.General concept of satellite hydrographic monitoring in the WeRA (Deliverable 1).2.Basic Data Set, criteria for data selection (Deliverable 2).3.Methodology of data processing (Deliverables 3 & 4).4.ARCTUR administrative software and databank - software pack for data processing, archiving and distributing (Deliverable 5).5. Stereophotogrammetric, interferometric and numerical models of coastal areas and processes in the WeRA (Deliverables 6 & 7).6. Hydrographic regime in the WeRA: present and future (Deliverables 8 & 10).7. Main results from field surveys and observations (Deliverable 9).8. Satellite image maps of the WeRA (Deliverables 11, 12, 14). 10. Inventory of ice shores in the WeRA (Deliverable 13).11. Summary documents on navigational and ecological aspects of coastal changes in the WeRA (Deliverable 15).12. Regional coastal reference database RECORD (Deliverable 16).13. Letters of intention from actual and potential users (Deliv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Autologous Stem Cell Seeded Tissue Engineered Trachea' (TETRA).

assistant: **Innovation**

CLINICAL PROBLEM AND UNMET NEEDThere are 11,827 patients with severe structural airway disease in Europe. Even with the current standard of care, when hospitalised this group of patients has a 22% risk of dying.  Patients are currently subjected to repeated surgical interventions (stent insertion) which have a high failure rate. Other therapeutic strategies under development include synthetic tracheal scaffolds seeded with patients own stem cells.  Preliminary data show that these scaffolds are poorly integrated and are susceptible to infection.TETRA PROJECTOur SME-led project will address the limitations of standard clinical care and competitor products under development and will:- Build on our successful compassionate use experience using autologous stem cell seeded scaffold-tracheal transplants in 48 patients- Follow on from our Phase I 4 patient INSPIRE clinical trial which will improve on the clinical prototype used in compassionate use cases- Conduct a 48 patient Phase II pivotal clinical trial to provide robust, quality data with validated GMP manufacturing processes to support an accelerated route to market for commercial exploitation in this orphan indication- Prepare a dossier for MAA submissionBENEFITSOur product, an ATMP, aims to eliminate the need for repeated surgical interventions of high risk and limited efficacy, reduce deaths and improve the quality of life for surviving patients.  If treating 20% of the patients with severe structural airway disease, we estimate that in Europe our technology will improve the quality and length of patient lives and result in savings of €517 million per year.We plan to further develop our platform technology to generate other complex tissues/organs such as bowel and liver replacements for clinical applications which wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Restoration actions to combat desertification in the northern mediterranean' in the context of a Fifth Framework call.

assistant: **Objectives**

REACTION aims at synthesise the more recent advances in the research on land restoration to mitigate desertification, together with the traditional knowledge on reforestation, and made it available to the National and Regional Action Plans to Combat Desertification in the Annex IV countries of the EU. The proposal will collect detailed information about successful restoration projects in the European Mediterranean countries using homogenised protocols.The projects will be evaluated through a consultation process with the participation of experts and stakeholders. Evaluated projects will be introduced in a database, available to the general public through internet. A handbook on 'Guidelines for designing restoration projects' will be produced and the general outputs disseminated at the local, national and international level. The activities of the AM will be structured through series of thematic workshops with the participation of all interested partners and relevant organisations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulatory mechanisms coordinating replication integrity and intra-S repair' to be submitted under Seventh Framework.

assistant: **Abstract**

The RecQ family of helicases, including BLM in human and its Saccharomyces cerevisiae homolog Sgs1, have important roles in maintaining genome stability. Sgs1 plays a specific role in response to intra-S DNA damage by resolving the pseudo double HJs resulting from replication-related sister chromatid junctions (SCJs). These catenated DNA structures are thought to represent template switch (TS) intermediates. Although the molecular mechanism is largely unknown, TS is thought to represent a major mechanism to bypass damage during replication. We recently showed that two genetic TS pathways, both of which involve homologous recombination (HR) factors, can lead to bypass of damage by means of SCJs and that their choice is regulated by sumoylation of a key replication factor, PCNA. We also found that the main TS pathway operating in cells involves the coordinated action of HR with the post-replication repair proteins Rad18, Rad5 and Mms2-Ubc13, which exert their role in promoting SCJ formation by means of ubiquitilating PCNA. Previously we showed that the resolution activity of Sgs1 and Top3 is regulated by Ubc9- and Mms21-dependent sumoylation, but the SUMO targets implicated with Sgs1 in this process remained unknown. In this project we plan to characterize the pathways that lead to TS and to understand the factors that promote different steps of this process and their regulation, using in vivo and in vitro approaches. We will attempt to understand how sumoylation is activated by intra-S damage and to address how the formation and subsequent resolution of these X-structures is coordinated with chromatin remodeling functions and topological transitions. We will characterize the X-shaped molecules formed during replication and we will attempt their visualization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Omics Phenotyping of Endocrine Disease in the General Population' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Metabolomics is a relatively new technology that provides information about levels of human metabolites, the low molecule products at the end (downstream) of the metabolic pathways of human physiology. In theory, metabolite profiles may more closely reflect the clinical phenotype and thus potentially improve risk prediction. Another advantage is that that they can be performed on non-invasive biofluids like urine. Several metabolomics studies have suggested that the metabolite profile of an individual can be used as a predictor of type 2 diabetes. However, evidence from large-scale population-based studies with comprehensive phenotypes of diabetes and thyroid disease is limited. The aim of the project is to identify urine metabolite profiles associated with risk of diabetes and thyroid disease and to investigate pathogenetic pathways by identifying genetic determinants of these metabolites. The project takes advantage of the long tradition of population-based and registry-based epidemiological research in Denmark. The experienced researcher will complete a training program supervised by two recognised Danish research institutions with complementary expertise in the fields of epidemiology and genetics, respectively. Hereby the experienced researcher will achieve competences in the field of statistical modelling of epidemiological data with repeated measures and use of the unique Danish registries for research. Furthermore, during the secondment at the partner institution the experienced researcher will receive training in genetic epidemiology. In return, knowledge of metabolomics will be translated to the beneficiary and partner organizations. It is expected that the results will provide novel insights into the pathophysiology of diabetes and thyroid disease and identify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cells in Matrix – an innovative 3D model for R&D of Diabetes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The demand for diabetes drugs keeps increasing as adult Diabetes prevalence reached 425 million people in 2017 (1 in 11 adults) and is estimated to rise to 629 million till 2045. The market of Diabetes drugs is expected to reach €80.5 Billion in 2019 while the investment in Diabetes drug development is ~ €4 Billion (CAGR of 13%). There is a constant need for more effective diabetes medications, hampered by the poor predictability of the current systems for identification of lead compounds during drug discovery. The failure rate of new drugs development is about 90% and the cost for reaching themarket with a new drug is ~ €1 Billion.Cells in Matrix Project develops an innovative 3D model for R&D of Diabetes Drugs , an Engineered Micro Pancreas (EMP) based on organ-derived 3D cell culture and human sourced insulin producing cells as an innovative tool for accelerating and cost reduction of Diabetes drug development. EMP system offers significantly extended shelf life and function for in-depth studies of drug molecules mode of action, validation, toxicology and in vitro pharmacokinetics, rendering higher prediction reliability.Cells in Matrix disruptive technology creates market added value to all the stakeholders, especially pharma industry, by improving compound screening at least X4 (from 5% rate of success today to at least 20%), resulting in cost saving that could reach €100 million per innovative new drug development.The project receives strong interest from stakeholders and plans immediate commercialization of the product to direct endusers, including academia and pharma companies, such as Boehringer Ingelheim.The FTI funding will enable market entry and validation & support external fundraising for the wider penetration of the global drug discovery market. Betalin