RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of cost effective reliable robust flexible compact and efficient degassing and aeration method for intensive aquaculture' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Land based fish farming is the critical success factor in intensive aquaculture since land based fish farms are the start of a very complicated value chain representing a prerequisite in order to have competitive sea farms as well as being an important Stool in order to develop and commercialise fish farming of new species. The aquaculture tank represents a production unit with the primary objective of creating a managed volume where the fish in the spawn and growth phase can be fed in an optimal water quality for cost efficient production of fish Water quality is one of the most critical factors in aquaculture. Optimum water quality is essential for survival rate as well growth rate of fish in the different phases of the life cycle and hence the productivity per m3 effective tank volume. The fish in the production units consume oxygen from the water. In addition there is a considerable discharge of food spill faeces and gases in water all of which do represent harmful effects on the biomass. With increasing reuse and recirculation of water degassing of water becomes more prerequisite.The project idea is to develop a cost effective reliable robust flexible compact and efficient degassing method which meets the needs of the aquaculture sector for removing oversaturated harmful gases i.e. carbon dioxide nitrogen and argon through development and application of ejector and nozzle technique for formation of micro bubbles for effective gas exchange in water integrated with sensor and control technology. The European aquaculture sector has increased substantially over the last decades. However overall production growth in Europe over the period 1994 2003 was 5.5% less than the global trend over the same period. The overall price trend was negative 0.5% APR vs positive global
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Neuronal circuits controlling motor behavior'.

assistant: **Objectives**

How does the assembly of neuronal circuits contribute to the emergence of function controlling dedicated animal behaviors? Finding answers to this question requires a deep understanding of the connectivity map of neuronal circuits controlling a behavior as well as the mechanisms involved in the generation of these specific circuit maps. In the project outlined here, I propose the analysis of the neuronal circuits involved in the generation of motor output, a behavior representing the ultimate output of nearly all nervous system activity. Studying the mouse motor output system will allow the analysis of neuronal circuit connectivity at an exquisite degree of specificity. Owing to the anatomical arrangement of motor neuron pools innervating individual muscles, this system offers the possibility to combine genetic, anatomical and physiological analysis of synaptic specificity with a direct link to a behavioral output. Generation of coordinated motor behavior is functionally linked to the high degree of specificity in presynaptic connections controlling the activation of individual motor neuron pools, yet knowledge on the specificity map of premotor circuits is currently missing. The aim of this research project is to acquire information on the general principles guiding the acquisition, maintenance and developmental plasticity of neuronal connectivity between premotor neurons and functionally defined subpopulations of motor neurons. This project is now possible due to the unique combination of our detailed know-how of the motor system in mice including a variety of genetic animal models, and the application of novel viral circuit tracing technology revealing monosynaptically connected premotor neurons, which we have recently applied successfully to the motor system in mice
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Tool platform for intelligent Patent Analysis and Summarization' in the context of a Seventh Framework call.

assistant: **Objectives**

Patents are the treasury of knowledge that drives the modern economies. The support of targeted search in this treasury has increasingly been topic of research. But search is just the first stage that provides the “raw” material that is to be analyzed, digested, assessed and summarized, depending on the concrete task of the user. Due to the wide-reaching consequences when a relevant patent remains undiscovered during search, patent search traditionally aims at high recall at the cost of lower precision, such that this raw material tends to contain many more irrelevant hits than in a general discourse search – with patent specialists reviewing mainly manually large quantities of patents in each phase of the search procedure. This is time consuming, expensive and often with a less than optimal outcome. TOPAS aims to bring to the market of IPR protection and management a new product that will provide high quality automatic means for content analysis and summarization of patent material, which will support the patent specialists in their daily work, leading to a much cheaper and better performance of the tasks. It will significantly contribute to the competitiveness of the work faced by any innovation-oriented company with an IPR agenda, and in particular, by the clients of the SME’s products: patent departments within companies, patent lawyers and innovators. The preparatory work for the development of the TOPAS technologies has been carried out in the FP6 project PATExpert, with the participation of three partners of the Consortium.The benefits will originate from the integration of functionality requested by clients for targeted and efficient IPR protection into the existing product lines SME’s, allowing for direct commercialization by SME’s together with their products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CEN standard Certified Experts EU-wide qualification and training scheme based on EPBD mandated CEN standards' to be submitted under Horizon 2020.

assistant: **Abstract**

In order to reach the EU's energy and climate targets, a qualified building workforce is needed.  Professionals need to be aware of new upcoming challenges: (e.g. nZEB, renewables, new state of art) and be trained on it.The objective of this proposal is to set up a large-scale qualification and training schemes to increase the skills of HVAC professionals related to the new upcoming challenges. HVAC professionals play an important role in energy efficiency, especially in renovation where HVAC systems are often replaced or upgraded first. The proposed training schemes are based on CEN standards related to the EPBD and mandated by the European Commission. The standards were voted positively in January 2017. The new CEN standards offer innovative approaches and solutions including renewables, economical calculation (cost optimum) and measured energy . To bring them into application, training is urgently needed. Several national calculation methodologies for energy performance of buildings are based on current CEN standards and they have to be replaced by new standards. The proposal is focusing  on increased skills of HVAC professionals with direct links to the EPBD and Ecodesign Directive (e.g. Lot1, Lot 2). CEN standards are also used for the common EU voluntary certification scheme requested in the EPBD. The training scheme will be complemented by a qualification scheme. It addresses strong market request, shown by the support of stakeholders of the whole building value chain.   Qualification and training based on European standards is an advantage for mutual recognition of qualifications and certifications schemes among different EU Member States. Standardisation is also key to create level playing field conditions for products European wide.     The consortium includes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Archeometric study to reconstruct the pollution and the climate of the past and their effects on cultural heritage' (1994-1998).

assistant: **Concept**

* To contribute at a quantitative evaluation of the local climate and pollution of the last millennium, beside results obtained on ice, lake or marine sediments archives far from sources, * To relate this evaluation to the past weathering of monuments, * To distinguish the past weathering from present day cumulative effect.The objectives of this project will be attempted by means of the establishement of a chronology and semi-quantitative evaluation of the urban and back-ground pollution in England, France and Italy as well as a chronology of the main environmental factors that have an important role in the present archaeological context and, on the other hand an objective analysis of samples of pollutants emitted in past centuries and an objective evaluation of the past deterioration of monuments. The methodology and main sources of information will be: * Laboratory analysis of in the field collected samples of ancient crusts, deposits and patinas, (raw samples and microsamples, thin sections, resin embedding and counterproofs. A large range of technics will be employed as, for instance, Reflexion and Transmission Polarizing Microscopy, Analytical Scanning and Transmission Electron Microscropy, X-Ray Fluorescence, etc.) * Archive documents on the past pollution and climate written by contemporary people. * The in the field sampling will concern ancient deposits on well dated parts of monuments enclosed latter by new constructions and disclosed recently; artifacts (statues, architectonic pieces, commemorative plaquets,..) exposed outdoors and then kept protected indoors in the museum or lapidarium; archaeological remains burried during a long period of time and then excavated and removed towards laboratories and collections. * The reconstruction of the past polluted env
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Novel ferroptosis inducers for the treatment of non-small cell lung cancer'.

assistant: **Objectives**

Despite significant advancements in the molecular characterization of certain types of cancer, many of these discoveries have yet to translate into substantial improvements in clinical outcomes. While targeted therapies are available, patients harbouring common oncogenic driver mutations often experience relapse. Prognosis is even poorer for those without identifiable oncogenic driver mutations. In cases with high PDL1 expression, single-agent immunotherapy typically leads to disease progression, whereas patients with low expression levels require additional toxic chemotherapy to achieve comparable outcomes. This underscores an urgent medical need for more effective therapeutic strategies for specific cancer subtypes. Ferroptosis, a form of necrotic cell death marked by the iron-dependent oxidative destruction of cell membranes, offers a pharmacologically tractable avenue for treatment. The strong reliance of certain tumour subtypes on cellular systems to suppress ferroptosis creates exciting opportunities for innovative therapies. We recently identified ferroptosis suppressor protein 1 (FSP1) as the second mainstay in ferroptosis suppression, functioning independently of the main regulator GPX4. Since the genetic or pharmacologic inhibition of FSP1 alone is sufficient to suppress certain tumour types in the in vivo context, FSP1 emerges as a compelling drug target. Here, we aim to further optimize the activity, selectivity, and pharmacokinetic profile of our newly identified FSP1 inhibitor family. We also seek strive to expand our patent portfolio to ensure broad IP coverage. Our primary objective is to identify a new lead compound—or potentially a preclinical candidate—for cancer treatment, thereby advancing FSP1 inhibitors toward preclinical and clinical development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Central Repository for Digital Pathology' (BIGPICTURE) under Horizon 2020.

assistant: **Objectives**

BIGPICTURE, a pathology-led consortium, has the vision to become the catalyst in digital transformation in Pathology. Our mission is to create the first European GDPR compliant platform, in which both quality-controlled Whole Slide Imaging (WSI) data and advanced Artificial intelligence (AI) algorithms will exist. The BIGPICTURE platform will be built on existing assets of ELIXIR EU data infrastructure, including the federated European Genome-phenome Archive (EGA) technology for managing the exchange of confidential information between contributors and users. The consortium will use Cytomine, an established open-source, cross-platform framework to develop unique tools for access to WSI, including annotations and visualisation of algorithm results, while we will develop new and generic models to facilitate AI development and mining of WSI data. By engaging and building consensus with all the relevant stakeholders, we will contribute to the development of a regulatory framework for digital slides and AI-based methods. Finally, BIGPICTURE envisions sustainability of its platform through a community- based model which relies on reciprocity, value creation and inclusiveness.To achieve our vision, we have brought together Europe’s leaders in the field of computational pathology who have access to national and European high-performance computing infrastructures as well as Europe’s fully digitalised pathology departments. Additionally, the consortium has currently access to approximately 4.5 million clinical WSI covering a wider range of indications through 17 partners and 23 third parties from the largest European and international pathology and trial groups. Our consortium is further strengthened by the presence of the European Society of Pathology, Digital Pathology Associat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A smart centrifuge camera for testing dewatering ability of waste-water sludges in hyper-gravity' (SludgeCam).

assistant: **Concept**

The EU produces more than 45000 tons of waste-water sludge per day as byproduct of municipal and industrial water purification activities. This enormous amount can become a gold mine for materials recovery, or an environmental burden, depending on how well waste-treatment plants can remove water from these sludges. Today sludge treatment processes are based on unoptimized methods, which rely on operator experience and low-tech equipment, and are not able to deal with the fast-changing sludge type evolution, resulting in loss of time, energy and money, as well as a negative environmental impact.The SludgeCam project will deliver an innovative smart camera centrifuge, having advanced software, hardware and sensing features, which will enable plant operators to consciously adapt treatment process parameters, select flocculant polymers and set standards for different sludge types, based on solid, reproducible data, so that more environmentally-friendly water treatment operations and drastically reduced energy consumption for sludge incineration will be achieved.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Anchoring ligandable binding sites at E3 ligase surfaces for plug-and-play PROTACs.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The Anchor E3s project proposes to establish, for the first time, an efficient protocol for the discovery and characterisation of accessible binding sites at any patch of a protein surface, regardless of its involvement in biological function. One of the motivation of the research is to develop a general approach to discover new “anchor” ligands that can enable improved plug-and-play proteolysis targeting chimeras (PROTACs) as chemical degraders of any protein of interest. The project will build on results from the host lab who identified a series of low molecular-weight fragments addressing novel patches at the surface of Cullin RING E3 ubiquitin ligases (CRLs) with currently unknown functionality, demonstrating that accessible and “ligandable” binding sites can be found on CRL surfaces. A combination of structure-based computational techniques informed by biophysical experiments and X-ray crystallography will be used to reveal, characterise, and target new ligandable binding sites at CRL surfaces. Promising anchor fragments will then be identified and grown into suitable binders, and eventually linked to assemble novel PROTACs, which will be assessed in cellular assays. The ultimate goal of the research is to develop and establish the PROTAC approach as an efficient and universal chemical biology platform for target validation, regardless of the perceived “druggability” of the targeted protein.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Critical Archives of Ordinariness: Vernacular Moving Image Practices and Migrant Identity in Polish Chicago' (Not-So-Ordinary).

assistant: **Innovation**

This project explores home movies and related oral histories of Polish Chicago before the digital era (1960s–2000s) to challenge and broaden our understanding of evolving migrant and diaspora identities. Following critical archive studies’ call to empower communities underrepresented in historiography by developing and interrogating archival collections, the project juxtaposes home movies – “ordinary” motion pictures created for family and close friends – with interviews with their creators to uncover the “not-so-ordinary” capabilities of this underused data source for studying minority groups. The project investigates a specific case: the interplay of vernacular moving image practices and the transformations of Polish diaspora identity in Chicago; however, it leads to conclusions of wider significance. By creating a research collection of home movies and related oral histories, it demonstrates how to contextualize historical home movies. By showing how evolving analog home movie technology (shift from film to video) altered vernacular moving image practices of the Polish diaspora, it contributes to media archeology. By reconstructing transnational micro-histories of home movies circulating between countries, it expands the field of transnational history. By identifying the role of vernacular moving image practices in shaping identities, it contributes to cultural anthropology and migrant/diaspora studies. By providing guidance on home movies as a research source and by showing the use of the movie-interview analytical unit, it enhances the empirical toolbox for social sciences and the humanities. To go beyond the state of the art while ensuring mutually beneficial knowledge exchange, the project combines the complementary expertise of a postdoc (visual culture, identit