RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Application of Functionalised Oligoprolines in Asymmetric Catalysis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Although oligoprolines have been known for decades up till the recent years they have only been applied as spacers in the study of energy and electron transfer phenomena. Recently a new methodology for the functionalisation of their backbones has been developed. The great flexibility of the reported synthetic approach both with respect to the number and character of introduced motifs allows for effective fine-tuning of the properties of these helical oligopeptides.Herein we propose to apply functionalised oligoprolines as novel asymmetric organocatalysts and chiral ligands for metal-catalysed transformations. Successful demonstration that the helical chirality can be transferred efficiently into an enantioselective transformation will be a very important contribution to the area and may result in the establishment of new class of catalysts.We also aim at creating switchable systems in which we will control the catalytic activity of these compounds by a simple, external stimuli. This will constitute a major achievement in the fast growing area of modern chemical sciences focusing on mimicking the behaviour of natural catalytic systems.The ultimate goal of the project however is design and operation of a supramolecular catalytic assembly line consisting of oligoproline units. We plan to create a platform which will catalyse the synthesis of an oligomeric specie from monomers in solution, however only when its’ single oligoproline components assemble together to create the ‘active form’ of the catalytic system. Successful accomplishment of this task will be a landmark contribution to the fields enantioselective catalysis, supramolecular chemistry and nanotechnology and could lay the foundations for a new class of functional synthetic systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Drugs targets in sympathetic neurons controlling adiposity.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Obesity is a metabolic disorder with unmet medical need for which a pharmacotherapy is urgently needed. The Domingos lab has recently discovered that sympathetic (SNS) neuro-adipose junctions mediate lipolysis and fat mass reduction (Pirzgalska, R.M., Cell, 2015).Thus direct and targeted activation of sympathetic inputs to adipose tissues could represent a new strategy for the induction of fat loss. Our main objective is to identify drug targets in SNS neurons innervating fat, which are suitable for an anti-obesity therapy. To achieve this, we will use technologies such as Translational Ribosome Affinity Purification (TRAP) for translational profiling of neurons innervating fat. We will differentially screen for molecular targets that are enriched in SNS neurons in fat. We will validate target expression in human SNS tissues. This project will identify neuro-excitatory drug targets in sympathetic inputs to adipose tissues, and may lead the development of pharmacotherapies which would circumvent side effects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The interpretive function and syntactic category of noun classes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A central goal of modern linguistic theory is to find out what properties are shared, and what properties are different across human languages.  Following Chomsky (1981, 1988), the shared properties are attributable to Universal Grammar, i.e. our innate capacity to learn a human language, and following Borer (1984) the variable ones are due to cross-linguistic differences in inflectional elements or grammatical markers.  The proposed research project pursues this broadly defined question, but focuses specifically on different kinds of noun class markers and in particular how animacy based noun class markers differ from gender-based ones in their interpretive function and syntactic category.  I explore the hypothesis that these formatives may realize the category responsible for either CLASSIFICATION or CATEGORIZATION, two functions that interact closely with one another, and assumes that the choice between them will have subtle, but important grammatical consequences. Taking a cue from the clausal domain, I will explore the hypothesis that these are the nominal counterparts of v (pronounced “little v”) and INNER (SITUATION) ASPECT, cf. Rijkoff 1991, Wiltschko 2011, Megerdoomian 2000.I propose to undertake comprehensive case study of Blackfoot, a language with animacy-based noun classes, in conjunction with comparative studies of other languages that differ from Blackfoot in their utilization of noun classes.  In particular, I will compare Blackfoot to Hebrew, a language with gender based noun classes.  The hypotheses I develop from this comparative approach will be tested against a range of other languages, which differ from the focal languages with respect to noun class assignment. In this way I hope to achieve a better understanding of the distinctive properties of Bl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Engineering synthetic pentatricopeptide repeat proteins for the site-specific genetic manipulation of plant organelles' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Mitochondria and chloroplasts are essential organelles that carry out the fundamental cellular process of respiration and photosynthesis, respectively. Organelles possess their own genomes that are physically separated from the nuclear genes, and mutations in their genome lead to serious consequences on organismal homeostasis and viability e.g. flower sterility in plants and mitochondrial myopathies in humans. However, contrary to the nucleus, methods for the genetic engineering of organellar genomes in multicellular organisms are either lacking or too laborious to be widely applied. Thus, there is a need for the development of such tools. To address this issue, I will exploit nature’s design and engineer the largest protein family of organelle gene regulators found in eukaryotes, the pentatricopeptide repeat (PPR) family. PPR proteins are nuclear encoded RNA-binding proteins that function in the posttranscriptional regulation of organellar gene expression. The PPR RNA-binding domain is composed of multiple repeats of 35 amino acid long stretches. Each repeat recognizes a single base in the target RNA sequence whose identity is defined by a code involving 2 amino acids in each repeat and we can now design artificial PPR repeat proteins with programmable RNA binding specificity. The PPRdesign project will establish new methods for the site-specific control of organellar genes in the Arabidopsis model plant by targeting customized synthetic PPR repeats to specific RNA sites in chloroplasts and mitochondria.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Entrepreneurial Organizing in the Platform Society' (PAY4PLAY), addressing dissemination and exploitation.

assistant: **Impact**

Digital platforms increasingly integrate financial transactions into social interactions, facilitating new ways of coming together and creating value. PAY4PLAY sets out to develop a new theory of organizing that grapples with the intersection of sociotechnical systems and socioeconomic relations that characterizes public life in the platform society. I focus on creator communities, defined as primarily platform-based associations formed around media personas with (1) hierarchal structures, (2) monetized interactions, and (3) asymmetrical relationships. I approach the project’s overarching question—How do people form communities around media personas and with what consequences?—from three perspectives: culture, infrastructure, and policy. Across each perspective, I compare three types of creators (gamers, VTubers, and adult content creators) working in three languages (English, Spanish, and Japanese) to understand how factors such as occupational stigma, gender, technology, and geography shape opportunities for organizing. PAY4PLAY employs distinct methodological approaches and disciplinary toolkits drawn from media and communication, information science, and economic sociology best suited to engage with each perspective, investigating culture with multi-sited ethnography, infrastructure with digital methods, and policy with controversy mapping and stakeholder interviews. Through an integrative analysis of these methods, this project will conceptualize creator communities on their own terms, mapping the value they provide to those involved and their broader influence. PAY4PLAY will thus offer the first large-scale comparison of the industry conditions of monetized content creation, develop a new theory of organizing and platform power, create methodological tools for fut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'High performance and competitive new titanium reinforced alloys for aeronautic applications' (NEWTIRAL), addressing dissemination and exploitation.

assistant: **Impact**

Development of new high performance & low cost isotropic Titanium Matrix Composites produced by in-site" liquid (investment casting) & solid (powder metallurgy) manufacturing routes. European aeronautical companies are looking for higher performance materials, cost competitive, lighter than conventional titanium alloys & recyclable, which can improve the components efficiency & reduce fuel consumption through weight reduction, mainly, taking into account expected improvement in air traffic for next years. Scientific & tech. objectives: Technology transfer on solid manufacturing route from lab to industrial scale, develop suitable liquid manufacturing route at lab & industrial scale, use these techniques versatility to make elaborated shape & net shape components. Study conditions of recycling & re-usability of the components at lab scale."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Portable Characterisation of Sperm Motility' (PorCSperM) under Horizon 2020.

assistant: **Objectives**

Based on an ongoing ERC project on characterising and studying the motility of highly-idealised, model micro-swimmers, we have built and validated a first-generation portable prototype device for assaying accurately bull sperm motility. To move to a more advanced prototype requires integrated software and hardware development and the setting up of standard protocols to render the measurement procedure robust for non-expert operators. Such a device, with integrated hardware and software, for Portable Characterisation of Sperm Motility (PorCSperM) will assembled and applied to bull semen in this project, but is in principle applicable to other animals, and perhaps also to human fertility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Infectious triggers of chronic autoimmunity'.

assistant: **Concept**

This proposal builds on existing expertise and collaborations of a multidisciplinary Consortium of basic scientists and clinical investigators each of whom has made a substantial individual contribution to understanding the links between infection and autoimmunity. The aim of the INTRICATE Consortium is to prosecute a programme of Translational Research that deliniates the role of infection in the induction and perpetuation of severe systemic autoimmune disease with the ultimate object of identifying new therapeutic strategies based on knowledge of pathogenesis.Our strategy will systematically analyse the complex and diverse processes involved in a “model” human disease: - Anti-neutrophil cytoplasmic antibody (ANCA) associated systemic vasculitis (AAV). AAV is ideally suited because it is known to be caused by autoantibodies of defined specificity and second because it is strongly linked to infection to infection. INTRICATE will use mouse models to answer the specific question whether infection with clinically relevant bacteria induces autoimmune disease in transgenic mice that express the human autoantigen. The use of novel high-throughput antigen array technology in well-characterized patient cohorts and analysis of microbial and host specific mechanisms combined with genome wide association study (GWAS) will determine whether dysbiosis or infection with specific microorganisms triggers the induction or re-activation of AAV. Unraveling the pathogenic processes that are responsible for this chronic autoimmune disease and the knowledge gained will lead to the development of novel preventive and therapeutic strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of carbohydrate array technology to systematically explore the functional role of glycans in healthy and diseased states' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The development and production of glycoarrays will provide the foreground knowledge necessary to lead to a step change in the diagnosis and treatment of diseases ranging from cancers to autoimmune diseases. Carbohydrates play a pivotal role in the molecular interactions that govern biological events at the centre of health and disease. This has become more evident as the characterisation and identification of proteins and their interactions through proteomics has advanced during the last decade. Whilst proteomics is providing a wealth of information, it does not deal with the results of post-translational modifications such as glycosylation which are frequently the driving force behind the biological activity of proteins. This lack of information is beginning to be addressed by the emerging field of glycomics, the mapping of all carbohydrate-protein interactions. The proposed training network is multidisciplinary involving carbohydrate chemistry, array technology and application. The programme offers young scientist an outstanding opportunity to be involved in the development stages of the glycoarray technology and apply this technology to important biological questions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bone motion Capture from video sequences'.

assistant: **Objectives**

The analysis of human movements, gathering quantitative information about the musculoskeletal system during the execution of a motor task, plays a fundamental role for the understanding of the system physiopathology. Current methods for capturing accurate 3D human motion require the attachment of devices like markers, fixtures or sensors, that may influence the execution of natural movements, require time for subject preparation, and must occur in laboratory environment. Markerless, video-based, techniques are emerging as a solution to overcome these problems, but their application in clinical practice and biomechanical research is still limited because no good solution yet exists to accurately estimate bone movements from standard video. In particular, observed deformations of soft tissues in video data may alter predictions of bone location. An unexplored step in the direction of building a reliable video-based technique for markerless bone motion estimation is to design a model to accurately infer the movement of the underlying bone from the external structure. The design of such model is the main objective of this research and will be enabled by simultaneously captured bi-plane X-ray and video sequences. Being able to predict the bone movements from external measurements can open up non-invasive analysis in natural environments that can significantly improve our understanding of articulated body kinematics. The outgoing phase will take place at Brown University (USA), where a group of researchers have recently set up a state-of-the-art 3D X-ray imaging system for visualizing the complex bones and joints motion during natural activities. The Brown team also has developed state of the art methods of markerless human shape and motion analysis. The return phase will tak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Characterisation of bromo, a respiratory burst oxidase in the development of root hair cells of arabidopsis'.

assistant: **Objectives**

Active oxygen species (AOS) are involved in stress response but their involvement in developmental control is poorly studied. The characterisation of the Arabidopsis bromo mutant, a mutant in NADPH-oxidase-related gene affected in root hair elongation, will characterise the role of AOS during root hair development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Genetic improvement of wood quality : increasing selection efficiency for different end uses' (GENIALITY) under Fourth Framework.

assistant: **Objectives**

Tree breeding can tailor the wood properties of any given species to meet the requirements of processing industries. The aim of this project is to increase the efficiency with which tree breeders can select genotypes of economic value to foresters and wood users. This will be done by: influence the yield and quality of end products; - identifying molecular markers for a subset of- these properties, for use in marker-assisted selection; - determining economic weights for wood and utilisation properties, for use in selection indices. Heritabilities of wood and utilisation properties, and the genetic correlations between them, will be determined in four species: Pinus pinaster (maritime pine), Pinus sylvestris (Scots pine), Picea abies (Norway spruce) and Eucalyptus globules. Genetic tests of an appropriate structure and age are available for the study. Destructive sampling will provide discs and logs for the assessment of wood density, fibre dimensions, chemical composition, solid wood properties (strength and durability) and pulping characteristics (chemical and mechanical). Linkage analysis and QTL mapping will be used to identify molecular markers for wood properties in Pinus pinaster. Bulk segregant analysis and selective genotyping will be used to identify markers in Picea abies. A 'candidate gene' approach will be used to elucidate the biological significance of detected qtls. The method of desired gain and the RESI computer programme will be used to estimate economic weights and determine index coefficients for use in Smith-Hazel selection indices. Selection indices of value for pulp and paper production will be constructed for all species. Selection indices of value for sawnwood production will be constructed for Pinus sylvestris and Picea abies. This project is e