RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Tipping Point from Genome Instability to Cancer' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cancer starts years to decades before diagnosis. Yet, early stages of tumor development are poorly understood. In particular, the precancer landscape of chromosome instability (CIN) is understudied, due to the scarcity of precursor lesions and methods to analyze CIN in single cells. The research presented here will address how the instability rate of the genome, followed by selection, determines whether a CIN-driven tumor arises. I hypothesize that the onset of CIN is the tipping point that governs the fate of a precancer clone. Using spatially aware and single-cell multiome methods that we developed, we will dissect essential factors that lead to malignancy via CIN, including extrachromosome circular DNAs. We will analyze two solid tissues at opposite ends of the cell turnover spectrum, which deeply diverge in regeneration capacity, clonality and constraints, namely the brain and the gut.Aim 1 will assess the instability rate of the human genome using the postmortem brain as a model tissue. CIN patterns vary greatly in frequency and type across brain tumors; we will compare the background incidence of fundamental types of CIN in normal cells to CIN signatures after selection has acted, in diagnosed tumors of the same lineages.Aim 2 will dissect CIN in space and time from the cell of origin, to identify what discriminates nascent clones that may cause cancer from those that do not. Timecourses in mouse models will reveal how CIN contributes to selective advantages and how nascent CIN-positive clones escape elimination by immune cells.Aim 3 leverages human precursor lesions to probe the role of CIN as a central gatekeeper between tumor initiation and growth, using the gut as a longitudinal in vivo system to directly capture the tipping point to cancer.  Unstable Genome w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Deformation and Recrystallization Mechanisms in Metals'.

assistant: **Concept**

Combining strength and formability, metals are indispensable for modern life. Their properties firmly depend on processing, typically involving a series of plastic deformation steps that introduce defects deep below the surface. Our current understanding of the evolution of defect structures is phenomenological, and strongly limited by characterization tools being either limited to surfaces or not available at deformation levels relevant for metal processing. D-REX strives to radically improve our understanding of structure-property relations in plastic deformation and thermal annealing of metals by visualising and quantifying the structural dynamics in 3D with 100nm resolution – within bulk metals. This will be achieved by developing a unique multi-scale full-field X-ray diffraction microscope enabling time-resolved 3D strain and orientation mapping. Using pink beam diffraction imaging, the time resolution of the microscope is expected to be ~100× better than the existing diffraction imaging methods. The unique experimental results will be used to guide and validate crystal plasticity and phase field models.D-REX opens a new way to address the unresolved questions of how metals get stronger during deformation and how this affects the annealing processes. For the first time, industrially-relevant deformation levels can be quantitatively and systematically mapped in real-life conditions. This will not only lead to a new scientific understanding, but also provide unprecedented access to critical material parameters from the bulk that will refine material models. More broadly, the novel multi-scale methodology and systematic approach of D-REX will be a game-changer for studies of many hierarchically-ordered crystalline materials.


**Keywords:** Plastic deformation, disloc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Software version control, documentation and test management' (VERDEST) under Fourth Framework.

assistant: **Objectives**

Objective of PIE is to put into practice version control, document management and automated software testing tools to improve and develop software design and development process itself in our company and in our associated partner organisations. Improvement means more automated customer requirements and applications version control, integrated document libraries and more automated and systematic testing procedures.THE EXPERIMENTDuring the project we plan to integrate in our process new tools for project and development environment to help our version control, testing and documentation.1. At first stages, project and customer requirement documentation is handled with document management system, using computer-based information management system enables us to concentrate to actual work, not to paperwork itself.2. Second, while the baseline project proceeds to programming stage, a version control system will be introduced to keep track of changes to program source and library files and to ensure that all users of the files access to the same master copy of each file. The version control will be integrated with documentation functions. 3. Third, automated testing tools will be used before the software is released in order to shorten the testing period The documented and partially automated test procedures guarantee that complete tests are run in every change situation. The goal of our baseline project, the Portfolio Systems Development Project, is to design and develop a new high quality object-oriented financial trading, portfolio management and analysis systems for foreign exchange, money and equity markets to replace our present CUI/DOS- based and develop Windows-based software products.EXPECTED IMPACT AND EXPERIENCEVersion ControlHave the off-the-shelf version control to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Design, characterization, and evaluation of biofilm eradicating hybrid liquid crystalline nano-coatings for new 3D porous orthopedic implants' (LC-NanoCoat), addressing dissemination and exploitation.

assistant: **Impact**

Orthopedic implant-associated biofilm infections represent a major public health and socioeconomic burden due the intrinsic tolerance of biofilms that behave as protective and immobile scaffolds to conventional antibiotics and immune system. Further, their long-term and repeated antibiotic treatments lead to an increased potential of antibiotic resistance development. Here, this interdisciplinary proposed project integrates innovative aspects of surface chemistry, 3D morphological characterization of coated implants, and precision engineering with attributes for production of much needed biofilm-targeting nanostructural implant coatings. It also considers the urgent societal needs for introducing an effective, flexible, and universal approach in orthopedic implant patterning and functionalization for combatting and preventing implant-associated biofilms. This core approach is based on controlled patterning with inverse non-lamellar lyotropic liquid crystalline phases having unique nanostructural versatility through prior precision priming of new 3D porous implant surfaces with tailor-made coating method, and their thorough characterization by using different modalities including GISAXS, neutron reflection, high-resolution X-ray photoelectron spectroscopy, and X-ray micro-computed tomography. This is in combination with in vitro profiling on model implant-associated biofilm infections. The project provides an environment with independent research activities for building my professional skills in a research topic at the interface of nanoscience, surface chemistry, and experimental medicine. In addition to training at different synchrotron facilities, my research career will be certainly advanced owing to the gained experience with state-of-art biophysical tools and superv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deep Integration Agreements' (DIA).

assistant: **Innovation**

This project aims to improve our understanding of deep integration agreements, which have generated an extraordinary amount of controversy in recent years. Unlike ordinary trade agreements, deep integration agreements do not just focus on reducing tariff barriers but seek to achieve much broader economic integration. Prominent examples include the Transatlantic Trade and Investment Partnership (TTIP) negotiated between the EU and the US and the Comprehensive Economic and Trade Agreement (CETA) negotiated between the EU and Canada. I proceed in three complementary parts, focusing on the most controversial deep integration issues. In a first part, I consider provisions regarding investor protection including the Investor-State Dispute Settlement System. My ambition is to provide a comprehensive theoretical treatment of international investment agreements, which sheds light on their fundamental purpose and assesses their real-world design. In a second part, I turn to efforts towards regulatory cooperation such as CETA’s Regulatory Cooperation Forum. Here, my goal is again to provide a broad theoretical analysis, which identifies the scope for regulatory cooperation and makes suggestions for their real-world design. In a third part, I study intellectual property rights protection, specifically the agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). In particular, I propose to take a canonical model of intellectual property rights agreements to the data and quantitatively assess the efficiency and equity implications of TRIPS.


**Keywords:** Trade policy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'UNIVERSAL RADIO-LINK PLATFORM FOR EFFICIENT USER-CENTRIC ACC'.

assistant: **Innovation**

URANUS investigates the design of a universal radio link platform being able to access any existing proprietary and standardized wireless system in a unified way, to support simultaneous usage of links in different types of air interfaces and, in particular, to ease the introduction of future personalized communications and reconfigurable air interfaces. It is based on a novel and efficient parametric approach to describe wireless transceivers (TRXs) in the complex baseband using a Generic MultiCarrier Representation (GMCR), where a specific signalling format or mode is uniquely represented by a corresponding set of parameters. The approach is referred to as Canonical Parametric Description (CPD), since the proposed overall transceiver structure (unlike software-defined radio) is independent of the specific choice of the parameter set. The CPD can be used to describe any mode, given that the parameters are properly chosen, which in turn translates to corresponding TRX requirements. The anticipated benefits for the user include better coverage, adaptivity in different environments, and selection of air interfaces matching the user/service/cost requirements. The main motivation to choose a GMCR for the CPD is the limited complexity of multicarrier transceivers and the fact that recent wireless standardization proposals are already based on orthogonal multicarrier signals. The baseband architecture of the CPD approach being inherently scalable with respect to the achievable data rate will be identified and implemented in software and hardware validation platforms. In order to quantify the system level benefits of multi-mode operation in relevant metrics such as spectrum usage, coverage, throughput and load-balancing, the performance of the URANUS platform will be simulated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Biogas production from biomass in the solid state for increasing the proportion of renewable energy sources.'.

assistant: **Objectives**

In Europe, the generation of energy from biomass is an area with considerable hitherto unused potential which could be applied, in particular, to the production of biogas for fuelling gas turbines in CHP plants or for driving fuel cells. Available kinds of biomass include residual wastes, household wastes of organic origin, wastes from the food industry, garden and hoticultural wastes, material harvested from areas left fallow, and also animal manure. (Waste of only 10% of the EU population, would give rise to an energy potential of 7400 GWh or harvested materials of the areas left fallow within the EU would give rise to an energy potential of 85600 GWh.) At the present time these materials are treated without generation of energy. An alternative procedure which combines aerobic and anaerobic processing to generate biogas from biomass in the solid state (water content 20-70%) could avoid disadvantages of other treatment processes. This project should develop this laternative process for the efficient production of biogas from biomass in the solid state and to render it mature enough for series production.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Heating and structure of Stellar Chromospheres' (CHROMORAD).

assistant: **Concept**

The bulk of radiation of a star originates from the photosphere, its visible surface. The temperature surprisingly increases outwards through the stellar atmosphere until, in case of the Sun, million of degrees are reached in the corona. While it has been shown that the required heating in the corona is due to magnetic fields, it is yet not clear for the layer in between, the so-called chromosphere.The chromosphere is hard to observe and difficult to model so that, despite large progress during the last de cades, the thermal structure of stellar chromospheres, including the one of the Sun, and the related heating processes are still poorly understood and controversially debated. The heating, that is attained by pure mechanical heating via shock waves and/or processes connected to magnetic fields, must provide sufficient energy to counterbalance the radiative emission derived from observations of chromospheric diagnostics like the spectral lines of calcium and magnesium. This emission varies strongly between different stars, suggesting a different coverage with magnetic fields, but is always larger than the so-called basal flux. Recent simulations and also high-resolution observations suggest that the layer is highly structured and very dynamic. A time-dependent and spatially resolved numerical simulation is thus mandatory for a realistic description.The project proposed here aims at the development and implementation of new methods to realistically describe the energy balance of stellar chromospheres, including simple model atoms for the most important agents calcium and magnesium and the resulting coupling between radiation field and chromospheric gas. The final goal is a set of three-dimensional self-consistent magnetohydrodynamics simulations with realistic chromosph
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Algebraic and Kähler geometry' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The purpose of this project is to study basic questions in algebraic and Kähler geometry. It is well known that the structure of projective or Kähler manifolds is governed by positivity or negativity properties of the curvature tensor. However, many fundamental problems are still wide open. Since the mid 1980's, I have developed a large number of key concepts and results that have led to important progress in transcendental algebraic geometry. Let me mention the discovery of holomorphic Morse inequalities, systematic applications of L² estimates with singular hermitian metrics, and a much improved understanding of Monge-Ampère equations and of singularities of plurisuharmonic functions.  My first goal will be to investigate the Green-Griffiths-Lang conjecture asserting that an entire curve drawn in a variety of general type is algebraically degenerate. The subject is intimately related to important questions concerning Diophantine equations, especially higher dimensional generalizations of Faltings' theorem - the so-called Vojta program. One can rely here on a breakthrough I made in 2010, showing that all such entire curves must satisfy algebraic differential equations. A second closely related area of research of this project is the analysis of the structure of projective or compact Kähler manifolds. It can be seen as a generalization of the classification theory of surfaces by Kodaira, and of the more recent results for dimension 3 (Kawamata, Kollár, Mori, Shokurov, ...) to other dimensions. My plan is to combine powerful recent results obtained on the duality of positive cohomology cones with an analysis of the instability of the tangent bundle, i.e. of the Harder-Narasimhan filtration. On these ground-breaking questions, I intend  to go much further and to enhance m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Tracking the movement and dynamics of Holliday junctions' (HollidayTrack), addressing dissemination and exploitation.

assistant: **Impact**

omologous recombination (HR) is a DNA repair pathway that plays a central role in the maintenance of genomic stability and cancer prevention. In the late stages of HR, recombination intermediates (Holliday junctions, HJs) need to be resolved to allow proper chromosome segregation. Whilst HJ processing reactions have been well characterised in vitro, there is limited knowledge of the dynamic properties of these structures within a cellular context. To explore the biological properties of HJs in vivo, I will use site-specific DNA cleavage and ChIP-sequencing techniques to reveal the distance of HJ migration from the site where HR is initiated. The ability of HJs to branch migrate spontaneously or be driven by potential HJ translocases will be determined using RAD54, BLM, WRN, RECQ1, RECQ5 and FANCM deficient cells. To enable these studies, my first challenge will be to develop a molecular tool that specifically detects HJs in vivo, that can be used to monitor the appearance and kinetics of HJs after DNA double strand break formation. The specific DNA break sites and corresponding HJ migration will be determined with respect to the dynamic chromosome domain architecture and organisation within human cells, which will provide valuable insights into the impact of local chromatin structure on HJ migration and resolution. Additionally, the newly developed HJ-specific tools may be applied to ask a wide range of questions relating to the role of HJs in telomere biology and replication fork reversal or to study patterns and distributions of HJ formation and migration in different cancer cell types.


**Keywords:** Homologous recombination, Holliday junction, branch migration, DNA helicases, chromatin topology