RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Engineering Directional Communication Pathways in Coordination Cages' (CageComm), addressing dissemination and exploitation.

assistant: **Impact**

Proteins, functioning as enzymes, receptors, nanomotors, and transporters, have inspired the creation of numerous artificial molecular systems and materials that mimic biological structures and behaviors. However, replicating their dynamic behaviors and intra-protein communication pathways, which are responsible for allosteric interactions and signal transduction, remains a significant challenge. The ""CageComm"" project aims to emulate protein-like allosteric interactions and intra-protein communication pathways using multicavity molecular coordination cages. To achieve this, ""CageComm"" will develop novel directional mechanisms for intra-cage communication, enabling control of one cavity's features through the remote stimulation of another, and integrate them into asymmetric multicavity palladium(II) coordination cages. Like proteins, these coordination cages will be capable of receiving a stimulus, directionally transmitting the signal, and generating outputs such as structural changes, guest binding, or alterations in photophysical and chiroptical properties. Two primary mechanisms for intra-cage communication will be established: guest-induced twisting motion transduction and stimuli-responsive expansion/contraction motion transmission via palladium(II) re-coordination on ""gear-like"" ligands. Implementing these mechanisms will provide access to advanced features and behaviors of the cages, including structural remote control, remote sensing, cage-to-cage transformations, signal transduction across phase interfaces, and non-linear responsiveness.""


**Keywords:** Coordination cages, Allosteric interactions, Signaling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A genome editing-based approach to study the stem cell hierarchy of human colorectal cancers' (EDITCRC) under Seventh Framework.

assistant: **Objectives**

A hallmark of cancer is tumor cell heterogeneity, which results from combinations of multiple genetic and epigenetic alterations within an individual tumor. In contrast, we have recently discovered that most human colorectal cancers (CRCs) are composed of mixtures of phenotypically distinct tumor cells organized into a stem cell hierarchy that displays a striking resemblance to the healthy colonic epithelium. We showed that long-term regeneration potential of tumor cells is largely influenced by the position that they occupy within the tumor's hierarchy. To analyze the organization of CRCs without the constraints imposed by tumor cell transplantation experiments, we have developed a method that allows for the first time tracking and manipulating the fate of specific cell populations in whole human tumors. This technology is based on editing the genomes of primary human CRCs cultured in the form of tumor organoids using Zinc-Finger Nucleases to knock-in either lineage tracing or cell ablation alleles in genes that define colorectal cancer stem cells (CRC-SCs) or differentiated-like tumor cells. Edited tumor organoids generate CRCs in mice that reproduce the tumor of origin while carrying the desired genetic modifications. This technological advance opens the gate to perform classical genetic and developmental analysis in human tumors. We will exploit this advantage to address fundamental questions about the cell heterogeneity and organization of human CRCs that cannot be tackled through currently existing experimental approaches such as: Are CRC-SCs the only tumor cell population with long term regenerating potential? Can we cure CRC with anti-CRC-SC specific therapies? Will tumor cell plasticity contribute to the regeneration of the CRC-SC pool after therapy? Do quiesce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Protective clothing for improved safety and performance in the fisheries', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Safe@Sea addresses the strategic objective to reduce the risk of injury in complex systems through advanced personal protective equipment.The main objective of Safe@Sea is to develop a new generation of advanced personal protective clothing for the fishing industry that will lead to a significant increase in safety without reducing work performance.Fishing is among the most dangerous of all professions. The concept behind Safe@Sea is to increase safety by implementing improved solutions for buoyancy, tear and puncture resistance, head and hand protection, emergency warning and positioning systems. This will be achieved by the integration of state of the art materials and ICT systems and the development of new high performance materials. An ergonomic design will be developed to solve the contradictory requirements of functionality, comfort and safety.Specifications will be developed (WP2) that provide input to concept development and prototyping (WP3) in close interaction with development and integration of materials (WP4) and integration of ICT solutions (WP5). The developed solutions, ergonomic design and usability will be thoroughly validated and tested (WP6). Manufacturing concepts, a standardisation strategy and roadmap for product maturing and market introduction will be developed (WP7). Demonstration of the technology developed and precommercial activities such as presentations of prototypes on exhibitions and trade fairs will take place in WP9. This will be supplemented by exploitation and dissemination activities (WP 8) and project management (WP1).The consortium consists of Ohmatex ApS, FOV Fabrics AB, SISYFOS AS, Grado Zero Espace SRL, International Safety Products Limited who are leading European SMEs that develop specialised fabrics, clothing and electronics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structural and functional studies of premessanger rnp transport through the nuclear pore' (1994-1998).

assistant: **Innovation**

Research objectives and content Nucleocytoplasmic transport occurs through the nuclear pores, large macromolecular assemblies which punctuate the nuclear envelope. Cytosolic factors play an active role as import receptors both in the recognition of the protein to be imported and in the translocation through the pore in conjunction with nucleoporins. The recent discovery of export receptors mediating both protein and RNA export indicate that import and export are intimately related. In the host laboratory I intend to collaborate with Prof. Bertil Daneholt to elucidate the mechanism of premessanger RNP export using the Balbiani Ring (BR) particles as model system. A detailed structural and functional study will be carried out using the giant salivary glands of C. tentans as an in vivo experimental system. Electron microscopy will be the main technique to elucidate the export pathway of the BR particles. In particular the translocation process through the nuclear pore will be analyzed and where applicable three dimensional reconstruction by electron tomography will be applied. Training content (objective, benefit and expected impact) During my stay in B. Daneholt's laboratory, I expect to learn more about the mechanisms involved in export of macromolecular assemblies, here exemplified by the BR pre-mRNP particle. Furthermore, I will be able to combine molecular biology techniques with advanced ultrastructural analysis, and I will get acquainted with the microinjection approach in studies of export. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Inverting α-glucosidase inhibitors as potential drugs for SARS-CoV-2' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Viral infections are still a major challenge in medical therapy. The recent outbreak of SARS-CoV-2 has again shown the immense threat these pathogens pose. In contrast to the direct-acting antivirals approach (targeting viral proteases, polymerases or other viral enzymes involved in replication), which is mostly followed by the pharmaceutical industry, this proposal targeting host cell enzymes involved in the biogenesis of infectious virions. In this context inverting α-glucosidases are of special interest. They play an important role in cell functions, such as the correct folding of proteins in the endoplasmic reticulum (ER). However, up to now selective inverting α-glucosidase inhibitors are scarce, and chemical probes that report on these selectively in biological samples non-existent. The dedicated aim of this proposal is to overcome this absence of inhibitors and probes.To identify novel inhibitors, activity-based protein profiling (ABPP) will be applied. This powerful analytical method is a driving force in chemical biology and medicinal chemistry but depends heavily on the availability of mechanism-based enzyme inhibitors. Based on current knowledge on retaining α-glucosidase inhibitors, unprecedented inhibitors and probes for inverting α-glucosidases will be developed and applied to ABPP. Their synthesis follows a divergent synthesis method to efficiently produce a wide library of compounds, that will be screened on the target enzyme, human ER α-glucosidase I. As the work on retaining α-glycosidase has shown, inverting α-glucosidase inhibitors are likely to be important tools for advancing many areas of application that are outside the primary scope of the proposed research (antiviral agents). Overall, my proposal on inverting α-glycosidase inhibitors and probes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SET Plan – The 10th Year Anniversary  Central European Energy Conference 2017' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The main objective of the project is the organization of the international conference 10th Year Anniversary SET Plan - Central European Energy Conference 2017. The 10th Year Anniversary SET Plan conference will be once again conjoined with the 11th annual Central European Energy Conference (CEEC 2017) and organised in Bratislava, Slovakia. The conference has an ambition to create a prestige international platform offering a floor for open discussion about the most important issues regarding current EU energy policy and research and innovation policy between relevant stakeholders. The conference will examine achievements in the implementation of the Energy Union with a special focus on the Low Mobility Package, State of Play of the negotiations of the 2016 Winter Packages, and the outcome of the 2017 Tour of Europe. In particular, the research and innovation achievements in Europe in the past 10 years that have supported the development of clean, sustainable, efficient and affordable energy technologies for low carbon energy systems in Europe. The conference will pay special attention to evaluation of the role of Central European member states, including their contribution to the implementation of the goals of the Energy Union and the Integrated SET-Plan.The conference will bring together researchers and policymakers from various member states, in particular, from the region of Central Europe, as well as a range of stakeholders from international organizations, research organisations, business, municipalities and civil society to encourage open debate around key energy issues. The program of the conference will consist of ten main panels, five parallel workshops held in a form of dinner sessions, poster session, and will also include side events.


**Keywords:** SET Plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Advanced Polymeric COmpounds and Metal Matrix Composites for  Excellent Performances in Machine Tools applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The COMETA  project aims at solving the following problems of SMEs European machine tools manufacturers: -Get high “Thermal” stability, in order to minimise  thermally-induced errors arising from thermal deformations of the machine structures caused by internal/external heat sources.  -Get high “Dynamic” stability, in order to minimise vibration (forced and chatter) and inertial effects of machine structures. COMETA intends to reach this goals through the integration and tailoring (to specific need machinery sector) of  innovative materials,  and exploiting a double-side solution: -Novel and mouldable polymeric short fibers  “Compound” (SFC) to be used to produce complex parts (flanges, inserts, …) of  machine that are use to interface mechanical components (e.g. motors,  guideways, spindle, ….) with the rest of the structure made of composite. The proposed SFC is composed of reinforcement (glass or carbon) with short fibres, powdered or impregnated with proper % in volume of thermoset or thermoplastic resin. Switching from metal interfaces (aluminium/steel) to Compound material would bring: extremely lower thermal drift; weight reduction, thus lower energy consumption and lower part inertia; no galvanic corrosion. -Aluminium matrix composite (AMCs) materials to design and realise low-weight (and hot) parts of machines with excellence mechanical performance  (e.g. spindle case, bearing spacer, multi-spindle head, motor base, etc.). The reinforcement in AMCs could be in the form of continuous/discontinuous fibres, whisker or particulates. Properties of AMCs can be tailored to the demands of different Machine tool applications by suitable combinations of matrix, reinforcement and processing route. The major advantages of AMCs compared to unreinforced materials are as foll
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Scientific Large-scale Infrastructure for Computing/Communication Experimental Studies - Preparatory Phase'.

assistant: **Objectives**

The digital infrastructures research community continues to face numerous new challenges towards the design of the Next Generation Internet. This is an extremely complex ecosystem encompassing communication, networking, data-management and data-intelligence issues, supported by established and emerging technologies such as IoT, 5/6G, cloud-to-edge computing. Coupled with the enormous amount of data generated and exchanged over the network, this calls for incremental as well as radically new design paradigms. Experimentally-driven research is becoming worldwide a de-facto standard, which has to be supported by large-scale research infrastructures to make results trusted, repeatable and accessible to the research communities.SLICES-RI (Research Infrastructure), which was recently included in the 2021 ESFRI roadmap, aims to answer these problems by building a large infrastructure needed for the experimental research on various aspects of distributed computing, networking, IoT and 5/6G networks. It will provide the resources needed to continuously design, experiment, operate and automate the full lifecycle management of digital infrastructures, data, applications, and services.Based on the two preceding projects within SLICES-RI, SLICES-DS (Design Study) and SLICES-SC (Starting Community), the SLICES-PP (Preparatory Phase) project will validate the requirements to engage into the implementation phase of the RI lifecycle. It will set the policies and decision processes for the governance of SLICES-RI: i.e., the legal and financial frameworks, the business model, the required human resource capacities and training programme. It will also settle the final technical architecture design for implementation. It will engage member states and stakeholders to secure commitment and fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Early phases of planetary birth sites -- environmental context and interstellar inheritance' in the context of a Horizon Europe call.

assistant: **Objectives**

The aim of this ambitious research project is to produce the most realistic computer simulations of the assembly of gaseous protoplanetary accretion discs, and to understand which of their traits are inherited from and/or affected by their direct interstellar context. Owing to ground-breaking instruments such as VLT/Sphere or the ALMA telescope array, we now have a first extensive census of disk populations. Moving beyond the core characterisation of relatively isolated disks in the calm Class II stage, the time has come to shift the focus towards the wider context of these systems, that is, the actively star-forming stellar associations, such as the archetypal Taurus, Orion or Lupus regions. Stellar ages of disks with substructure of (likely) planetary origin point to the fact that planet formation is not merely an ubiquitous process, but figuratively speaking happens within the blink of an eye. This mandates to abandon the assumption of the disk as a quiescent entity detached from its surroundings, and instead place it in the context of a collapsing cloud core. Key aspects here are i) the external UV radiation field that can drive powerful photochemical reactions on the surface, ii) perturbations from stellar flybys, iii) gas self-gravity, and iv) magnetic field lines that are self-consistently anchored in the local interstellar medium (ISM); the latter aspect requiring adaptive-mesh technology, provided by the NIRVANA III code, co-developed by the applicant. At the same time, the early appearance of planets poses questions about the solid constituents potentially being inherited from the ISM and “primed” during the protostellar precursor phase. Finally, with the pivotal exchange of angular momentum during the collapse regulated by non-ideal MHD effects, the evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The generality, mechanism, and function of bet-hedging in bacteria' under Seventh Framework.

assistant: **Concept**

Gene circuits exhibit fluctuations (‘noise’) in the levels of key components such as regulatory proteins. Increasingly, noise appears to play functional roles, e.g it can enable a subpopulation of cells to enter a transient antibiotic-resistant state, enhancing their survival. By ensuring that cells do not all exist in the same transcriptional state, the colony can ‘bet-hedge’ against future  environmental changes.Studying bet-hedging is critical to our understanding of how bacterial gene circuits have evolved in an ever changing and hostile environment. It is also important for public health. The spread of infectious diseases can depend on activation of alternative genetic programs, such as competence, general stress response, and antibiotic persistence in bacteria. I seek to understand the mechanisms by which cells enter these alternate states.Previous gene expression assays used bulk averages over thousands of cells, causing individual cell behaviour to be lost. I will develop new approaches to attack this problem. I will use single-cell time-lapse microscopy to examine the generality of bet-hedging  (Aim 1). I will construct and screen reporter strains for ~120 key pathways in B. subtilis. After screening for pathways that show variable gene expression,  I will use synthetic biology and mathematical modelling techniques to discover the gene circuit mechanisms that allow cells to probabilistically enter these alternative states (Aim 2).In order to test the function of the variable gene expression observed in our reporter strain for each candidate gene I will test whether, upon addition of antibiotics or other stresses, cells that are highly expressing the candidate protein survive or grow faster than cells that are not. I will do this using a novel microfluidic devic