RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'City tales: an art-based participatory framework for studying migration-related diversity' (ARTIVES).

assistant: **Concept**

This project will study imaginaries of diversity portrayed by Afro-European artists in Lisbon and Rotterdam in their films, performances and (oral) stories. These stories are not sufficiently related to in the mainstream discourses and the hypothesis is that the arts offer a particularly vibrant textual weft for exploring competing imaginaries of postcolonial urbanity. The two European ports are chosen since they position themselves as ‘open-to-the-world’ in light of their maritime history and ensuing migration dynamic. Yet they significantly differ in the ways that their municipalities frame their multiculturalism.I will build the framework of ‘urban artives’ – archives of situated stories – to explore non-essentializing conceptualizations of migration-related diversity. By close reading creative forms of storytelling; interviewing and following artists in their city wanderings; digitally mapping spaces of inspiration, production, and performance; and producing two creative outputs, ARTIVES will 1) trace transnational networks of belonging embodied in the local cultural scene and 2) test the possibilities and limitations in relating to these stories in ways that break away with ‘migrantising’ (Wiest 2020) conceptions of society.This research will transpose recent developments in the field of Critical Archival Studies, namely attempts to account for the transitory nature of identity formation in records’ preservation, to the fields of qualitative culture-oriented Urban Studies and Migration and Transnationalism Studies. In this way, ARTIVES will bridge the symbolic, material and affective aspects of how urban communities realize their sense of belonging and claim agency within highly diverse cities. Furthermore, the project will offer a best practice for working with co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pseudohypoxia-mediated cardiac regeneration' to be submitted under Horizon 2020.

assistant: **Abstract**

Ischemic heart disease is the main cause of death in Europe and the world, and its main manifestation is myocardial infarction (MI). The MI leads to loss of heart tissue, tissue scarring associated with fibrosis, dysfunction and heart failure. The pathophysiological basis of heart failure in humans lies in the heart's inability to regenerate. Adult cardiomyocytes (CMs) perform mitosis after MI, but their proliferation rate is extremely low for restoring normal cardiac function. During development, low levels of intrauterine oxygen promote the proliferation of CMs, which decreases postpartum due to the metabolic adaptation that implies exposure to atmospheric oxygen. Induced hypoxia in adult mammals promotes proliferation of CMs, and is required for cardiac regeneration (CR) of teleost such as zebrafish. However, the mechanisms that mediate these effects are unclear. Systemic exposure to hypoxia has been proposed as a strategy to promote CR; however, its adverse effects on other vital organs limit its clinical use. Here, we have proposed the generation of a temporary and localized hypoxia in the infarcted area of the heart. To achieve this, we will synthesize fibrin scaffolds bearing FG-4592 - an agent that mimics the effects of hypoxia (pseudohypoxia) - using bioprinting 3D. Besides, scaffolds will be loaded with CMs derived from Induced pluripotent stem cells (iPSCs-CMs), and will be implanted in MI models of pigs. Delivery of FG-4592 and iPSCs-CMs through scaffolds in the damaged myocardium would promote proliferation of resident CMs and cell turnover, respectively. Additionally, we will explore two mechanisms by which hypoxia could promote CR, remodeling of the extracellular matrix and angiogenesis mediated by angiopoietin-like 4 (Angptl-4). This project is a necessa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Telemedicine alliance - A bridge towards a coordinate eHealth implementation' to be submitted under Sixth Framework.

assistant: **Abstract**

The TM alliance consortium consisting of the European Space Agency, ESA, The World Health Organisation, WHO, and the International Telecommunication Union, ITU, initiated a cooperation in building a vision for provision of Telemedicine and eHealth to European citizens by 2010. In the course of the analyses performed and the activities undertaken by the consortium, an evident need of a super-national, objective and non-biased assessment and coordination body has appeared. The TM and eHealth area is so large and multi-factorial, that single 'sectors' e.g. the Electronic Health Card sector, the interoperability sector, or other, to a large extent work in relative isolation from neighbouring sectors, due to intrinsic high levels of complexity.Specialists active and qualified in one sector are handling well the questions for that specific sector, but have limited basis, insight or mandate to perform the crucial coordination with neighbouring sectors, making them function together in a compatible manner. The consortium organisations together represent background, experience and expertise needed to assess societal (health related), scientific, technical as well as organisational questions and propose solutions. As well, ESA has a solid experience as a backbone activity of that agency to manage international projects in a technical, scientific and political setting.Interoperability was one of the main concerns identified in the previous study, TM Alliance, and therefore the emphasis in TMA Bridge TMA-Bridge Specific Support Action will be on all aspects of interoperability: communication, database structures, medical workflow, reimbursement and legal aspects. In addition the vision defined in the previous study, will be disseminated as much as possible.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DEcentralized, cooperative, and privacy-preserving MONitoring for\ntrustworthiness' (DEMONS) under Seventh Framework.

assistant: **Objectives**

The Internet is not run by a single organization; indeed, this is a key characteristic of the Internet architecture, and a key reason behind its success as a platform for innovation in communications. Instead, the management, safety, and trustworthiness of each domain of the network are the responsibility of that domain; cooperation among these domains is largely done on a personal, and somewhat informal, basis.However, the growing complexity of the network leads to complex, emergent threats that challenge the ability of current cooperative efforts to respond. Large-scale network accidents", such as routing failures or software faults on widely distributed endpoints, are not confined within a single domain, and therefore difficult to react to. More troubling, organized criminal enterprises leverage vulnerabilities within the network across multiple domains to build "botnets", which are essentially large-scale coordinated infrastructures applied to a range of nefarious activities, from sending spam, to extortion scams through denial of service attacks, to the theft of personal financial information. There are societal challenges, as well, as growing awareness of privacy issues leads to unease with the traditional measurement approach of centralized storage and analysis of traffic information.Attempts to further centralize the response to these threats will simply not work. Therefore, network traffic monitoring and measurement must be made effective across domain boundaries in order to meet the challenges of this environment. Cooperative threats and distributed failures call for a distributed, cooperative detection and mitigation infrastructure. Specifically, DEMONS aims to design and demonstrate the operation of a network for cooperative monitoring. We will apply innovat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Teaming to Extend Maltese Ambitions in the Aerospace Sector' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TEMARA is a proposed teaming project between the Stichting Nationaal Lucht- en Ruimtevaartlaboratorium (NLR - the Dutch National Aerospace Laboratory), the Malta Ministry for Tourism responsible for Aviation and the Malta Council for Science and Technology. The proposed project, being the eventual establishment of a National Aerospace Centre (NAC) in Malta. TEMARA will consist of two stages, the first being a 1-year action plan for the creation of a Business Plan, and the second being a 5-7 year Framework Partnership Agreement for the financing of the operations of the NAC.The proposal is being submitted in accordance with Teaming call under HORIZON2020 ‘Spreading excellence and widening participation’.  In line with the scope of the call topic, TEMARA aims to team two parties: a leading institution of research and innovation excellence (NLR) and a new research agency at national level from a lower performing state (NAC) with the intention to establishing the latter as a Centre of Excellence.The overall strategic objective of the National Aerospace Centre is to become a viable Centre of Excellence providing a service to national stakeholders in the Aerospace sector with particular focus on supporting the continued competitiveness of the European Aviation industry while contributing to its growth, and to contribute to Maltese and European Research and Innovation (R&I).  This will generally be achieved through research and innovation excellence in science and technology. More specifically, the NAC would develop a pool of know-how and engineering capability to attract further investment in the aerospace sector, develop a critical mass in specific areas of specialisation, contribute to greater national and European competitiveness and reducing disparities between Malta and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterizing opposing BNST to VTA circuits that differentially regulate motivation and individual responses to stress' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In our daily life, we face many challenges that create stressful situations. Some individuals experience stress as motivational drive, whereas in others, it can reduce motivation and trigger avoidance behavior. Pathological responses to stress, such as depression and anxiety, take an enormous toll on society. Despite the relevance of stress on mental health, little is understood about the neuronal circuit mechanisms that underlie the behavioral differences in stress responsivity and why some individuals are more resilient to the negative impact of stress than others. The mesolimbic dopamine system plays a major role in the stress response. Work in the host lab found that trait anxiety influences how an individual’s motivated behaviors change with stress and that the anxiety level correlates with differences in the response of dopamine neurons in the ventral tegmental area (VTA) to the stress-induced neuropeptide CRH. Recently, two parallel pathways from the basal nucleus of stria terminalis (BNST) to the VTA –one glutamatergic and the other GABAergic– have been identified and are thought to influence anxiety and motivated behaviors.  However, solid evidence linking activity in these pathways to behavioral outcomes is lacking. The goal of this proposal is to monitor and manipulate the activity of these pathways using a combination of optogenetics, calcium imaging, and behavioral testing. I hypothesize that the glutamatergic and GABAergic BNST-VTA pathways are differentially engaged during stress. The balance between these pathways modulates dopamine release from the VTA, which then determines whether an individual would experience increased or decreased motivation in response to stress.  I will first determine the natural activity pattern of VTA-projecting BNST neurons a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional requirement identification development of methodology' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The FRIENDLY project has been organized in order to identify the necessary functional requirements of technical subsystems for Communication, Navigation and Surveillance to achieve the overall system performance criteria. Given the technology progress, the continuous evolution in the ATM concepts domain, this project will be limited to the definition of a methodology to enable refinement and validation of CNS requirements.It will start from identifying the functional concepts with respect to the use of CNS for future aircraft navigation and ATM within the different European operational regions. it will then move on to actually defining the functional requirements of CNS systems supporting the operational requirements of ATM according the operational European areas.The methodology for the validation of the above functional requirements will then follow through simulation means, aiming at their refinement. Measurements of significant parameters (safety, efficiency, etc.) will be performed.The methodology will be demonstrated on a selected sample of CNS functional requirements. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Bedside monitoring of infection based on exhaled breath'.

assistant: **Concept**

Molecular analysis of exhaled breath is a new frontier in medical testing with an enormous potential for monitoring respiratory disease.Breath tests are non-invasive and require minimal patient effort. This makes them applicable in a wide range of settings varying from theintensive care unit (ICU) to home. Respiratory infections are the primary cause of death in ICU. More than half of the patients in ICUsworldwide suffer from infections, which lengthen their hospital stays and increase their mortality rate. Timely detection and treatment isimportant and monitoring infection via breath analysis will have a major impact on healthcare. Electronic nose sensor technology is beingdeveloped but there is a need for clinical validation. Also it is not always clear to which specific compounds these sensors are sensitive. Inthis proposal the focus is on developing a sensor technique, where measurements are obtained and processed at the bedside. Thissolution will be dedicated to the detection of infection from breath. A synergistic approach is proposed between sensor technologydevelopment, clinical validation and complex data interpretation. Knowledge will be exchanged between an industrial partner (Philips, NL)strongly involved in the healthcare and well-being markets, two academic partners (University of Manchester, UK, Academic MedicalCentre, NL) that have an impressive track record in breath analysis research in a clinical environment and a research institution (University of Twente, NL) that has promising potential on bedside gas sensor technology that can be tailored to compounds of interest. The inter-sectorialknowledge transfers as defined in this proposal are key to the success of this ambitious goal. The project consists of 6 highly multidisciplinarywork packages, which i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The role of protein phosphorylation in biological response to genotoxie stress' in the context of a Sixth Framework call.

assistant: **Objectives**

Medal and 53BP1 have recently emerged as the key components of the cellular defence machinery, which guards against adverse effects of geotaxis stress. This research proposal embarks on elucidating of how phosphorylation of Medal and 53BP1 regulates genetic stability in human cells.Task 1 aim at mapping of phosphorylation sites of Medal and 53BP1 induced by DNA damage and/or replication stress.Task 2 includes generation of the phosphor-deficient and mimicking-mimicking mutants of Mac and 53BP1 and establishing human cell lines enabling to conditionally express these mutants after down regulation of the endogenous wild-type counterparts by RNA interference. Task 3 focuses on a comprehensive analysis of the roles of the 53BP1 and Medal phosphorylation for the kinetics and velocity of the DNA damage response using a battery of state-of-art molecular, biochemical and cell biology approaches including imaging of the key underlying biochemical reactions in live cells.Task 4 aims at generation of specific-specific antibodies to the identified residues-residues of Medal and 53BP1. Among others, these reagents will be employed in a broad immune- photochemical survey to study the potential cancer-associated checkpoint defects. The proposed experiments are expected to significantly broaden our knowledge about the fundamental genome safeguarding mechanisms and provide tools to identify how these mechanisms are subverted in human disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Key nutrient transport mechanisms important for the prediction of nutrient and p¨hytoplankton concentrations in european standing waters' in the context of a Fifth Framework call.

assistant: **Objectives**

Problems to be solvedThis project will identify and quantify important control mechanisms for nutrient retention and release within lakes and their catchments. The project will assemble nutrient budgets for a large number of lakes across Europe and intensively study a smaller selection in order to develop catchments nutrient transport models that account for critical physico-chemical and ecological differences among lakes. An understanding of these mechanisms will assist with the River Basin Management Plans proposed in the forthcoming European Council Directive establishing a framework for Community action in the field of water policy.Scientific objectives and approachThe project will have three stages. The first will be the collation of existing data on an extensive range of catchments throughout Europe. Data used will include variables that enable calculation of nutrient budgets of both nitrogen and phosphorus and an estimate of in-lake concentrations of phytoplankton chlorophyll a. The analysis of collated data will enable the identification of primary predictors of in-lake nutrient and phytoplankton concentrations. The second stage of the project will quantify those predictors among a series of intensively studied lakes and catchments. The work will partition and estimate flux rates of nutrients within and between different physical and biotic compartments of land and surface waters within catchments that represent examples of high to low intensity land-use across a range of geomorphologies. The third stage of the project will, based on the results of the project, develop mathematical models for the prediction of in-lake nutrient and phytoplankton concentrations.Expected impactsRisk assessment of nutrient enrichment of lakes through an understanding of the nutrient