RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'European network on Research Programme applied to the Protection of Tangible Cultural Heritage'.

assistant: **Innovation**

NET-HERITAGE is the first significant initiative ever attempting to coordinate national RTD programmes of European countries and support European RTD Programmes in the field of research applied to Protection for Tangible Cultural Heritage. It aims to exert a massive, positive impact through the following objectives: - provide an integrated picture of the state of the art of cultural heritage research in EUMember States and at the European level; -overcome the lack of a coordinated research structure in this specific and multidisciplinary sector, with programmes fostering integration between art-history-conservation-maintenance-restoration areas and architectural-chemical-physics-engineering areas; - limit fragmentation within and among national research programmes, identifying common strategic priorities for research and programmes; - create effective actions to stimulate the exploitation of research results, and underpin cooperation between researchers and cultural heritage institutions for the application of identified solutions; - face problems due to insufficient and dispersed funding, in terms of local level and size of funding, compared to other research sectors; - favour exchange between national and European work programmes, to avoid a single top-down approach. NET-HERITAGE intends to achieve the following main outcomes: - coordinating actions within the EU partnership; - favouring protection of moveable and immoveable tangible cultural heritage; - expanding the potential of the cultural heritage research sector; - enhancing dissemination of research results and news in the field of protection of tangible cultural heritage; - increasing the visibility of the socio-economic importance of this sector; - supporting educational and training programmes and activities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Exploring the Multilingual Advantage in Phonological Acquisition' (MultiPhon), addressing dissemination and exploitation.

assistant: **Impact**

The proposed project will assess bilingual, trilingual, and quadrilingual speakers of different combinations of Romance, Germanic, and Slavic languages on their phonological acquisition of an entirely foreign language- Modern Hebrew. This will be the first study to compare phonological acquisition of consonant clusters in a typologically distinct language between speakers of two, three, and four languages, allowing us to contribute to a long-standing debate in the field: do multilinguals have a cognitive advantage in subsequent language learning, or are they only transferring knowledge from previously acquired languages? This study will yield valuable theoretical implications in language acquisition and applications in the field of foreign language learning. First, from a theoretical perspective, it will allow us to tease apart mechanisms of language acquisition to understand whether phonological acquisition is a general language function (wherein more acquired languages lead to a greater ability to acquire new phonologies) or specific to the known languages (wherein the ability to acquire a new phonological system depends on the phonologies of previously learned languages). Second, although studies on bilingualism are now abundant, and L3 acquisition is a steadily growing field, little work has been conducted on the acquisition of further languages, and less still within the field of phonology. Thus, this study will pave the way in understanding how increasingly multilingual systems may differ amongst each other and facilitate the acquisition of new languages. In the field of language learning and pedagogy, this research will elucidate the ways and extent to which prior language experience can be harnessed when acquiring a new language. As part of the dissemination asp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The mitochondrial mono-ADP-ribosylation landscape', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Metabolism sustains life, providing the right amount of energy to keep the body active and responsive to a changing environment. Abnormal metabolism is at the heart of many health problems, including cancer, neurodegenerative disorders and diabetes, which severely affect an individual’s quality of life and have become high priorities for Europe. Our understanding of the mechanisms that underlie these diseases has rapidly evolved over recent years. Yet, the development of novel, effective interventions still requires the further identification and analysis of mechanistically ill-understood, but physiologically important molecular mechanisms and signaling networks.The MitoMAR project dissects mitochondrial mono-ADP-ribosylation, a highly dynamic, environment-responsive post-translational modification of cellular proteins, which links changes in mitochondrial function and NAD+ production to the aetiology of these diseases. We are studying the mitochondrial ADP-ribosyl-proteome under a variety of growth conditions and will describe the biological role of mitochondrial ADP-ribosylation for a subset of modified targets, characterizing their interaction with mitochondrial ADP-ribosyl polymerases and hydrolasesEvidence indicates that ADP-ribosylation biology underlies the pathomechanisms of cancer, neurodegenerative and metabolic disorders. The main aim of the MitoMAR project is to advance our understanding of the proteins and networks that are modulated by mitochondrial mono-ADP-ribosylation. Considering the central role of mitochondria and metabolism in human health, the expected results will be immediately useful to other researchers, and will ultimately facilitate the development of therapeutic approaches by identifying new drug targets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Potassium channel regulation by kcne proteins in human cardiac tissue'.

assistant: **Innovation**

The Department of Pharmacology and Toxicology of the Medical Faculty of the Dresden University of Technology is seeking a postdoctoral scientist (MD or PhD) experienced in molecular biology techniques. In the project human cardiac KCNE regulatory proteins", the candidate should complete our group of molecular biologists and electro physiologists with experiences in antisense oligonucleotide techniques and knowledge in cell transfection in heterologous and homologous cell systems. The main research topic will be to study the regional expression and distribution of human cardiac KCNE proteins (homologous with human minK-related protein, MiRP) and their regulatory role on cardiac potassium channels in expression systems and transfected cells. In a new building with excellently equipped laboratories for molecular biology, cell culture and electrophysiology, in a scientific stimulating environment within the center of theoretical medicine (MTZ) and nearby clinics and Max-Planck Institut for Molecular Cell Biology and Genetics the candidate will find excellent conditions to extend her/his scientific horizon. The beautiful city of Dresden and the surrounding landscape will certainly contribute to a successful and enjoyable period of research stay in Germany."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Team semantics and dependence logic'.

assistant: **Concept**

In the traditional so-called Tarski’s Truth Definition the semantics of first order logic is defined with respect to an assignment of values to the free variables.  A richer family of semantic concepts can be modelled if semantics is defined with respect to a set (a ""team"") of such assignments. This is what is called team semantics, a term coined by the PI in his 2007 monograph, and used ever since to describe this highly non-trivial modification of Tarskian semantics. Team semantics was introduced around the same time in inquisitive logic under the name state semantics. Examples of semantic concepts available in team semantics but not in traditional Tarski semantics are the concepts of dependence and independence. The PI introduced what he called dependence logic around these concepts. It appears that teams appear naturally in several areas of sciences and humanities which has made it possible to apply dependence logic and its variants to these areas. Now is the right moment to move from dependence logic to a broader explication of team semantics. This is what the TEAMDEP project proposes to do. In the TEAMDEP project we take team semantics to a new level by focusing on its hard axiomatizability questions and to its applications to the foundations of quantum mechanics and to the multiverse of set theory.""


**Keywords:** mathematical logic, team semantics, dependence logic, formal methods, multiverse, generalized quantifier, second order logic, set theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unlocking the potential of machine learning for SMEs by automated machine learning' (AutoML).

assistant: **Concept**

Machine learning has become a key technology for modern data-driven industrial applications. This success is built on recent research advances in the field of artificial intelligence and more specifically was enabled by key advances in machine learning. Unfortunately, the performance of many machine learning methods is very sensitive to a myriad of design decisions and thus requires a significant amount of machine learning expertise which is often rare and makes this technology inaccessible for small and medium-sized companies that cannot afford their own team of machine learning experts. My ERC grant BeyondBlackbox on automated machine learning (AutoML) addresses this problem from a research perspective. In it, my team and I developed methods which systematically and efficiently adapt and tune machine learning pipelines and implemented them into a research prototype. This resulting research prototype, in principle, allows ML novices easy and affordable access to the most advanced ML methods, automatically customized for the user's own data, and with this research prototype, my team and I have won several competitions, including competitions against up to 130 teams of human ML experts. The potential economic impact is substantial since AutoML technology saves computational resources and human time and therefore reduces the cost of creating value from ML. In this POC project, I and my team will transform our existing research prototype to a professional prototype, perform a technical validation, perform market research and build up business contacts to evaluate this prototype in an industrial setting. Furthermore, we will develop a sustainable business model and assess ways of commercializing the advances made in my ERC grant in order to bring them to market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative process for the synthesis of Alkali Ferrates in Fluidised Bed' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This proposal deals with the transfer of knowledge in the field of the synthesis of the alkali ferrates containing hexavalent iron. The alkali metal ferrates become a substance of growing importance for the water and effluent treatments. This is due to the ir unique multi-functional nature (oxidation, flocculation, elimination of heavy metals, decomposition of organic matter...). Tight environmental regulations in EU encourage using ferrates as a prime choice decontamination agent since after their use, ferrates are transformed into iron hydroxides and/or oxides being eco-friendly. However, these findings are limited by difficulties related to instability of ferrates, the costly synthesis methods as well as low yield of ferrates. Experience acquired on the ferrate synthesis allows to a new, cost effective, clean and competitive process for the synthesis of alkali ferrates, particularly Na-ferrate. It based on a dry route gathered in two successive steps: First step consists in the premixing of NaOH with FeSO 4.xH2O allowing the coating of iron sulphate in the sodium hydroxide leading to a single solid with a homogenous particle size. Second step of is devoted to the synthesis of Na-ferrate in fluidized bed by oxidation in diluted chlorine of the single solid obtained in first step. This method uses the cheapest possible raw materials for the ferrate synthesis: iron sulphate (it is a waste of titanium oxide production); NaOH price is lower than that of KOH, and chlorine is the less expensive envisaged oxidizing a gent. Na-ferrate synthesis is conducted at room temperature, all materials used are found in the synthesis product, and the synthesis process doesn't generate any waste. Na-ferrate synthesis might be considered as 'green chemistry'. To our best knowledge, it is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Interactive biomembranes for wound management – exploiting the unique wound healing and antimicrobial properties of human collagen VI', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This project's objective is to develop a wound dressing product that will address the unmet needs of patients with chronic wounds. The prevalence of chronic wounds is increasing and results in a growing utilization of healthcare and financial resources. The available wound care options can manipulate one or multiple aspects of the wound environment, but cannot form antibacterial barriers and facilitate healing to a satisfactory level at the same time.  Colzyx aims to address this challenge by developing an innovative wound dressing product that will make use of the newlydiscovered healing and antimicrobial properties of human collagen VI. It is first-in-class product which uses highly functional molecules from the human innate immune system in wound management. This novel technology combines these potent molecules with a biomembrane – established in wound management market. Together, they effectively enhance wound closure and fight bacterial infection simultaneously.  This approach offers significant benefits to patients by reducing pain and discomfort, and accelerating recovery. It will also shorten hospitalisation time and decrease labour for healthcare professionals and the financial burden. Comparing to available wound dressings, Colzyx’s product is unique and will address a new market category of interactive biomembranes.  The ultimate success will depend on the quality of confirmatory data and agreement with development partner to share the challenges of subsequent research and market introduction. Colzyx plans to take the product through the CE-mark registration study and reach the market through an agreement with a strong defined licence partner.  The problem of pathogenic resistance to drugs is growing and highlighted by the national and international health or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanostar Sieving for Oligonucleotide Therapeutics' (NANOLIGO).

assistant: **Innovation**

Since the Nobel Prize winning discovery of small interfering RNA its specificity and selectivity have driven the pharmaceutical industry to design 15- to 25-mer oligonucleotide analogues as a new class of drugs. These offer exciting new therapeutic possibilities for example in rare diseases, but also large patient population indications including cardiovascular disease, and viral pandemics such as Covid-19. However, the high cost and limited scalability of manufacturing these complex polymeric molecules using solid phase synthesis is holding back benefits for thousands of patients – and has motivated us to seek an improved technology for oligo synthesis.ERC Advanced Grant 786398 is funding research investigating a new technology platform for the fabrication of defined monomer sequence polymers - Nanostar Sieving. Our preliminary research into oligo synthesis using Nanostar Sieving has found that it is potentially both feasible and game-changing. NANOLIGO seeks proof-of-concept that Nanostar Sieving can unlock the tremendous potential of oligos through dramatically reducing production cost and increasing production capacity. We will work with RNA oligos – key targets for novel APIs – which are currently produced by solid phase synthesis, and show that these can be made entirely in the liquid phase, with unprecedentedly high purity, efficient chemistry and lower solvent consumption. Crucially, membrane separations are readily scaled up, making this process a strong candidate for kg-scale oligo production.The PI and members of his research team have founded a start-up, Excatmer, to ensure the results of the ERC Grant have impact. We will carry out the PoC project at Exactmer, so that if we are successful the technology can be more rapidly developed and scaled up, leading t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'ACHIEVE: Development of an oral ACG-based treatment to combat obesity, maintain long-term dieting success and improve metabolic health'.

assistant: **Concept**

Obesity constitutes an alarming global epidemic, exposing billions of individuals to a multitude of metabolic, infectious, & neoplastic health ramifications. While weight reducing interventions of the GLP-1 family are transforming medical weight reductive therapy, long-term weight loss maintenance remains a daunting unmet challenge, with most medically treated individuals rebounding to obesity. In our project, we will generate a first-of-its kind solution to this global need that will involve oral human utilization of microbiome-modulated weight-regulating interventions. In our ERC-funded project (Fluhr et al., Nature 2021), we discovered that depletion of several microbiome-modulated metabolites drives weight gain in smoking-cessation-induced weight gain. Oral supplementation of several of these molecules has led to a generalizable & significant weight reduction across multiple obesogenic conditions.Building on these findings, the ERC-PoC will develop a commercial metabolite-based treatment or supplement, that will safely attenuate weight gain, maintain long-term weight reducing impacts, and improve metabolic functions. The project includes four work packages:(1) Development and production of metabolite-based drugs and/or medical foods (following a rigorous market study in a dual path approach). (2) Testing these molecules for efficacy, mechanism and safety in obese/lean mice. (3) performing a first-in-human trial (using the most efficacious formulation) in obese/GLP-1-treated individuals (4) in parallel, conducting an extensive commercialization effort to translate our findings into a NewCo, based on 1-2 new products. Notably, there is currently no such orally administered long-term solution complementing weight-reducing therapies in maintaining weight over time. As s