RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Hypermutated tumors: insight into genome maintenance and cancer vulnerabilities provided by an extreme burden of somatic mutations' (HYPER-INSIGHT).

assistant: **Concept**

Mutations are the fuel of any evolutionary process, and this also applies to carcinogenesis. The advent of affordable DNA sequencing has enabled mutagenic processes in the human soma to be quantified genome-wide, revealing a striking occurrence of hypermutated tumors. They exhibit an extreme load of somatic changes, often harbouring hundreds of single-nucleotide variants and/or indels per megabase. The HYPER-INSIGHT project is organized into three objectives, which aim to take advantage of the unique opportunity provided by genome sequences of hypermutated and ultramutated tumors. In particular, this work planned in this project aims to further our knowledge on (i) the regional organization of the DNA replication and repair program in human cells, and the determinants thereof, (ii) the extent of selection which acts on somatic variants in various pathways or complexes and (iii) opportunities for selectively targeting DNA repair deficiencies that manifest as hypermutation. Methodologically, our work will employ a three-pronged approach. First, we will perform a multitude of rigorous statistical analyses that draw on the rich and still-expanding resources provided by cancer genomics consortia. Second, we will perform exome and genome sequencing, focusing on ultramutated tumors caused by specific defects in the DNA maintenance machinery. Third, the project involves conditional essentiality screens on cancer cell lines with hypermutant backgrounds. Their goal is to discover synthetic lethality relationships, useful for targeting hypermutating cells, while sparing healthy ones. In summary, one of the promises of cancer genome sequencing projects was to elucidate the mechanisms underlying mutational processes in the human soma, advancing our understanding of this important fa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integral automatic system for kitchen furniture manufacturing' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The main objective pursued with this project is to develop a pilot system to be applied in kitchen and accessories furniture manufacturing totally automated, from the transmission of a request through Internet until its delivery, without a direct intervention of working power. This carries out an important innovation within the kitchen furniture sector and will suppose a flexible production totally oriented to customer needs, to decrease drastically the lead time and the mistakes during the management and the production, and to minimise the waste and raw material employment. As specific objectives aimed in this project, it is worth to mention's. To automate totally the manufacturing process from the request transmission till the final product deliveries. To reduce the lead-time to the half. Nowadays, the average lead-time within the sector is about 30 days and with this proposal it will be decreased until 15 days. 3. To increase the product quality thanks to the administration and production management mistakes elimination's. To increase the raw material exploitation, reducing waste. 5. To reduce risks for the working power due to the manual works with saws or sharp items and also due to the contact with volatile and/or toxic dangerous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transnational Cooperation of the European Network of NCP SME' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The TranCoSME project intends to support the European network of National Contact Points for the SME-specific measures of the 7th Framework Programme (NCP SME) in their support to proposers in their respective countries. Objectives are to deliver a better quality of service, to increase the efficiency of the work and to enhance networking between the NCPs in Europe. These goals will be achieved by training measures and by setting up tools which help NCP SME during all steps of their daily work from identifying innovative SMEs over partner search to proposal writing. The tools and trainings will be provided by a core group of experienced and well-motivated NCP SME. The trainings, the communication platform and the partner search tool will form a stable and sustainable support to NCP SME enhancing the cooperation between organisations from all over Europe through. The background objective of the project is to raise the quality of proposals submitted in the SME-specific measures of FP7 and to increase the quality of consortia.   The countries all partners in the consortium are coming from covers the whole EU and all Associated states to FP7 with 36 partners. It is foreseen to have a project duration of 36 months (3 years).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dissipative self-assembly in synthetic systems: Towards life-like materials' (LifeLikeMat), addressing dissemination and exploitation.

assistant: **Impact**

Living organisms are sophisticated self-assembled structures that exist and operate far from thermodynamic equilibrium and, as such, represent the ultimate example of dissipative self-assembly. They remain stable at highly organized (low-entropy) states owing to the continuous consumption of energy stored in ""chemical fuels"", which they convert into low-energy waste. Dissipative self-assembly is ubiquitous in nature, where it gives rise to complex structures and properties such as self-healing, homeostasis, and camouflage. In sharp contrast, nearly all man-made materials are static: they are designed to serve a given purpose rather than to exhibit different properties dependent on external conditions. Developing the means to rationally design dissipative self-assembly constructs will greatly impact a range of industries, including the pharmaceutical and energy sectors.The goal of the proposed research program is to develop novel principles for designing dissipative self-assembly systems and to fabricate a range of dissipative materials based on these principles. To achieve this goal, we will employ novel, unconventional approaches based predominantly on integrating organic and colloidal-inorganic building blocks.Specifically, we will (WP1) drive dissipative self-assembly using chemical reactions such as polymerization, oxidation of sugars, and CO2-to-methanol conversion, (WP2) develop new modes of intrinsically dissipative self-assembly, whereby the activated building blocks are inherently unstable, and (WP3&4) conceive systems whereby self-assembly is spontaneously followed by disassembly.The proposed studies will lead to new classes of ""driven"" materials with features such as tunable lifetimes, time-dependent electrical conductivity, and dynamic exchange of buildi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microcystin Exposure Associated Toxicity', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Microcystins (MC) are potent cyclic heptapeptide toxins that are produced by many cyanobacterial genera e.g. Planktothrix, Microcystis. Human exposure occurs primarily during bloom events, via drinking or contact with contaminated water, food or aerosols. While food exposure and corresponding health effects are rare, exposure to high MC concentrations via drinking water has resulted in morbidity and mortality. However, little is known about the level of MC exposure in humans when sub-chronically or chronically exposed via aerosols or drinking water as is the case in populations living within close proximity to water bodies experiencing toxic blooms, e.g. the population of San Roque dam, Argentina. To accurately determine human exposure, an in-depth understanding of the physical and physiological events governing toxic bloom formation and regulating MC production is critical. In this study we will (1) undertake a series of in-lake mesocosm studies to explore thresholds and triggers of up-regulation of MC. Samples will be analyzed using a suite of sensitive molecular (QPCR, RT-QPCR, metagenome analysis), immunological and chemical techniques in concert with physical and geochemical measurements , (2) undertake a series of field-experiments, incl. the San Roque location, in which we will monitor a range of physiochemical  parameters, and in-lake and aerosolized MC levels, and (3) use a hydrodynamic model to define water movement coupled to an ecological model enabling predictions of toxins in aerosols and water. Laboratory techniques and questionnaires specifically developed to allow monitoring of human toxin exposure, will be used to assess health impacts of toxins and aerosols. The consortium represents aquatic ecologists, microbiologist, molecular biologist, modelers, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MONitoring and Assessing prevention and restoration soLutIons to combat deSertificAtion' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The main goal of MONALISA is to identify and promote the expansion of innovative and tailored solutions to prevent and reverse land degradation and desertification (LDD) while showcasing their socio-economic and environmental effectiveness. MONALISA will put in place a transdisciplinary approach to integrate scientific and local knowledge, emerging from newly and established social learning spaces with multi-sector stakeholders and multi-disciplinary and interdisciplinary researchers. Work will be carried out in six Mediterranean case studies (CS), encompassing different levels of aridity across five countries (European: Italy, Spain and Greece; and non-European: Tunisia and Palestine). In the CS, the following solutions to prevent and restore LDD will be assessed and scaled-out: (i) innovative grazing systems (e.g., adaptive multi-paddock grazing systems); (ii) microbial-based solutions (e.g., biofertilizers and symbiotic N-fixing rhizobia); (iii) conservation agriculture practices (e.g., cover crops and reduced tillage); (iv) ecological restoration practices (e.g., harvesting and seeding of residual plant materials in protected grasslands, green infrastructures); (v) water harvesting techniques; (vi) treated wastewater reuse in agriculture. One of the main outputs of MONALISA will be a multi-modular practice-oriented Decision Support System, composed of several web-based applications, that will leverage innovative data and technologies, including from remote sensing and Artificial Intelligence. MONALISA will focus on new business opportunities with (and not only for) stakeholders, taking into account cost-benefit and market analysis and the promotion of public and private investments. The main goal will be the promotion and adoption of sustainable and environmentally-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Omi user group on automotive and aerospace applications' (OMI-UG-TRANSPORT), addressing dissemination and exploitation.

assistant: **Impact**

The main objectives of OMI-UG-TRANSPORT are:- the creation of a forum for facilitating and stimulating the cooperation of users and suppliers of embedded microprocessor systems technology in automotive and aerospace applications, thereby becoming a leading edge meeting place, progressively creating an international business community; - the identification of specific requirements for automotive and aerospace applications in embedded microprocessor systems technology; - learning between users and in particular identification of common requirements in the automotive and aerospace applications; - learning between users and suppliers, thereby creating awareness of existing solutions on one hand and on user acceptance and needs on the other hand; - clear input to the OMI direction on user requirements in the automotive and aerospace industry, leading to a strong market orientation of the OMI programme and thereby larger reuse of results. As a result, OMI-UG-TRANSPORT will improve the information flow between technology users and suppliers and the OMI direction and stimulate new business opportunities. The benefits for all involved players will be a stronger focus on application driven research and development, leading to a faster transfer of technology from R&D to market applications and a larger deployment of European microprocessor technology in automotive and aerospace applications. This will result in a better competitive position of the European industry of automotive and aerospace, microprocessor and ASIC design houses, systems and software houses and silicon foundries.RationaleMicroprocessor systems technology has become a key issue in the design of performant, reliable and cost effective equipment. The European players in the embedded systems market have an interest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeting the Notch Protease Interface' to be submitted under Seventh Framework.

assistant: **Abstract**

NOTCH signaling is a highly conserved short-range signaling pathway involved in virtually every aspect of embryonic development and controls homeostatic self-renewal in many adult tissues. Germ line mutations in the NOTCH pathway cause several hereditary diseases, and somatic mutations are found in cancer. NOTCH pathway activity is governed by ligand induced proteolytic cleavage of the receptor in the extracellular domain by a metalloprotease. This cleavage is required for the consecutive transmembrane cleavage by the γ-secretase complex leading to the release of the intracellular domain that mediates target gene activation. The precise mechanism that confers ligand regulated NOTCH proteolysis is unresolved but involves a ligand-induced conformational change. Virtually nothing is known on how conformational changes render the NOTCH receptor susceptible to proteolysis and which proteases are involved. Human cancer prone NOTCH1 receptor mutations are characterized by increased metalloprotease dependent cleavage and signaling activity. Here I hypothesize that these oncogenic mutations lead to exposure of buried scissile bonds that facilitate proteolysis. Since metalloprotease cleavage of NOTCH receptors is the regulatory event in NOTCH cascade activation, inhibition of this protease activity may find therapeutic application in diseases with deregulated NOTCH signaling such as cancer. Novel technologies and reagents are needed to gain further insight into the NOTCH-protease interface to accelerate drug target discovery and validate their use in pre-clinical models for cancer where deregulated protease activity plays crucial roles in disease progression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetically enhanced electrocatalysis' (MAGNESIS).

assistant: **Concept**

In the last years, electrochemistry and electrocatalysis are increasing their impact across several fields. A major driving force comes from the promise of substituting current fossil-fuel powered thermal methods in the industry by electrochemical alternatives, driven by renewable electricity. However, electrochemical methods are still far from reaching the desired target performance. In this landscape, the recent discovery of magnetic fields enhancing electrocatalytic processes offers a plausible new strategy. The idea of boosting an electrocatalytic reaction by an external magnetic field becomes highly persuasive. Still, the origin of this phenomenon is hardly understood, given its complexity: dealing with a magnetic field, in an electric field, on a dynamic surface, during a chemical reaction is a multiple-body problem.Our objective is to foster magneto-electrocatalysis by exploring rigorously the interplay between magnetic fields and electrocatalytic performance from atomic resolution in model systems up to full cell devices. This can only be achieved by a synergetic effort between experts in catalysis, surface science, magnetism and theory. We will focus on two relevant reactions: the spin-restricted water oxidation and the carbon dioxide reduction, both potentially spin-sensitive. Our aim is to validate the structural, electronic and magnetic key descriptors controlling this phenomenon, assessed by complementary ex-situ and operando data within the corresponding theoretical framework. Computational tools will consolidate the understanding and quantify the different mechanistic contributions to microscopic and macroscopic observations. The ambition with MAGNESIS is to define, in a rigorous way, the first principles and ultimate possibilities of magnetic fields in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Precise utilisation of manures in agriculture' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Accurate measurement of plant nutrient concentrations (N, P and K) in animal slurries and solid manures is needed for optimal nutrient utilization in grass and arable farming. Such improvements will also help to reduce the risks of environmental pollution due to excessive applications. However, the required technology is not yet available, although users (farmers and agricultural contractors) and manufacturers offs lorry and solid manure applicators have requested suitable nutrient sensing and control systems. Thus, the purpose of this project is to develop accurate and robust systems for on-line measurement of plant nutrients in slurries and solid manures and to combine them with Global Positioning System (GPS) technology. This will greatly improve the control and registration of plant nutrients delivered during slurry and solid manure applications to land. The project will establish new collaborations between research institutes and industrial partners who until now have been working separately towards the development of the necessary systems. This will ensure rapid and efficient achievement of the project objective.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Climate Night Hamburg 2012' to be submitted under Seventh Framework.

assistant: **Abstract**

After successful Climate Nights in the last three years Climate Night Hamburg 2012 on September 28, 2012 again consists of attracting all the categories of the public at large and bring them together with climate scientists at one location. The last Climate Nights had around 30.000 visitors during each night and more than four million people reached by the awareness campaign each year. Climate Night 2012 is a further development of the three recent nights organised by the coordinator marking the continuation of a well-adopted and entertaining concept in the City of Hamburg.During the night on September 28, 2012 scientists will be the focus in all the activities organised and attendants will constantly be in direct contact with them, having the possibility of exchanging on any topic of their interest, linked or not to the job as researcher. Researchers are to be shown as ordinary people and the profession researcher as fundamental for the well-being of the society. Visitors have the chance to interact with researchers in diverse manners. The research focus in Climate Night 2012 will be put on architecture and climate change. Researchers will open their work to the public and showing aspects of their life as researchers.The new focus on architectural science is best transformed in one of the most prominent inner-city waterfront development projects in the world, the HafenCity. Therefore this district will be the major location of Climate Night Hamburg 2012. Another focus will again be put on Climate Change. A recent EU survey shows the increased public concern about Climate Change and the need for the awareness of economic benefits of action. The political discourse about nuclear power plants has also boosted the interest of the population and media in the whole area of C