RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Innovative 5R SOLutionS for Textile Integrated Circular Economy' (SOLSTICE).

assistant: **Innovation**

SOLSTICE aims at demonstrating 4 replicable systemic solutions for the territorial deployment of the circular economy (CEC) for the major industrial sector of textiles (62Mt produced/year). All steps of waste prevention and management will be included in a 5R strategy: Refuse/Reduce, Reuse, Repair, Repurpose, Recycle. The solutions developed can be replicated and cross-linked with the plastics value chain. SOLSTICE will:•Develop tools and strategies to implement the 5R approach:oFor the 4R Refuse/Reduce, Reuse, Repair, Repurpose:- Engage the different stakeholders (industrial companies, local authorities, citizens) to revise their supply chains / behaviour, and become more sober, circular and sustainable.- Scope and map current state, carry research on and analysis of relevant circular interventions per territory,- Create a methodology and blueprints of CEC interventions to be tested/piloted- Define circular guidelines and indicatorsoRecycle: Demonstrate innovative chemical recycling technologies, able to treat efficiently part of the major streams of polymers in textiles and plastics (PET, elastane, polyamide, polyurethane) in mild conditions. The technologies allow to recycle multicomponent and bio-based materials, complex streams, and to recycle textile into textile or coating into coating (closed-loop) or into added-value applications (open loop). They are easily adaptable and allow a local recycling.•Set-up a traceability system based on a Digital Product Passport and designed in relation to existing initiatives.The demonstration will take place in 4 EU representative and complementary territories. Knowledge-transfer and cooperation between the cities and regions involved, and with CCRI and other stakeholders and projects, will ensure an optimised development and d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Low-cost, high-throughput quantitative phase microscopy' (LOCOSCOPE) under Horizon Europe.

assistant: **Objectives**

High-content screening is rapidly gaining traction across the biological sciences as a means to acquire more detailed data and test more hypotheses in an unprecedentedly rapid and systematic manner. However, a key issue identified by its users is that the instrumentation costs are too high, with systems typically costing from €150.000-800.000. This limits ownership of the instruments to well-funded research labs and, in doing so, excludes a significant portion of the multi- billion USD potential market. This project aims to target this unserved lower end of the market with a competitive high-content screening platform costing just €10.000.To achieve this, we’ll employ a novel quantitative phase imaging method originally developed for x-ray imaging as part of an ERC Starting Grant. The method allows us to make microscopes much simpler and less expensive without sacrificing image quality. So far, we’ve successfully demonstrated that our new imaging approach is fast, robust and can be readily utilized in such a low-cost screening system. Moreover, our IP is novel, protectable and in the process of being patented. This project will take the next steps towards commercialization by developing our prototype into a minimum viable product, and by carrying out extensive research into the market and customer base to determine the optimum price point, develop a field-tested sales pipeline and revenue model, and create a robust business plan for the eventual spinout company.Our decision to pursue the market for low-cost devices carries significant risk in that it necessitates high market penetration to achieve sufficient sales volume. However, should we successfully mitigate this risk (e.g. via focused development of the sales strategy), our endeavor will eliminate the main entry ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Single-molecule analysis of Holliday-junction (HJ) migration by the human double-HJ dissolvasome' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The project outlined here investigates the molecular mechanisms of the critical final steps of homologous recombination (HR) based DNA repair, a pathway that supports the error-free repair of double-stranded DNA breaks (DSBs). In HR, the broken DNA ends are processed and homologous DNA provides a template for repair. Engagement of both processed ends leads to the formation of a double Holliday-junction (DHJ) structure. DHJ can be resolved by enzymatic cleavage or dissolved by the concerted action of a specialized group of helicases (RecQ-family helicases including Bloom’s syndrome helicase (BLM)) and Type I topoisomerases (e.g. TOP3A). In humans the ‘dissolvasome complex’ consists of BLM, TOP3A and regulatory proteins (RMI1, RMI2), called the BTR complex. The BTR complex dissolves DHJ by 1. convergent branch migration of the two independent HJs and 2. decatenation of the final hemicatenate structure. Thus, dissolution solely results non-crossover products, which is necessary to avoid chromosomal rearrangements. What is the mechanism of HJ migration? What are the exact roles of the subunits of the BTR complex? How long can a HJ migrate (i.e. how processive is the ‘dissolvasome’)? How specific is the DHJ migration to the BTR complex compared to other human RecQ helicases? Here we aim to address these questions by using state-of-the-art single-molecule and solution biophysical and biochemical techniques. We will generate a previously inaccessible mobile HJ substrate integrated into λ-bacteriophage DNA. We will follow the processes underlying HJ migration by fluorescently labeling the BTR complex, HJ position and DNA end in total internal reflection fluorescence (TIRF) microscopy combined with microfluidics. Elucidation of the detailed roles of the BTR components in HJ bran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Differential geometry in braided categories'.

assistant: **Objectives**

My research project is dedicated to the study of braided non-commutative differential geometry which has one of its origins in the theory of quantum groups. I am interested in the construction of braided analogues of (bicovariant) differential calculi on (Hopf) algebras, and in the study of Hochschild and cyclic homology in braided abelian categories. I want to find out if there exist similar close relations between these braided structures as in the classical symmetric case where the objects usually are modules over a commutative ring k. Training content (objective, benefit and expected impact) The project generalizes structures of non-commutative differential geometry to braided categories. Extensive use has to be made of categorical methods in braided abelian (ribbon) categories as well as of homology and of differential geometry on (bi- and Hopf) algebras. suitable generalization of these structures to braided categories have to be found. The enlargement of my knowledge and skills through the project will help me to continue my work in the feld of braided mathematics" and to advance also in other fields of mathematics like low-dimensional topology and Topological Quantum Field Theories. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Craving in the Body' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Despite extensive research and numerous therapeutic efforts, addiction remains a chronic condition for many individuals, with relapse rates alarmingly high. Traditional approaches predominantly emphasize cognitive and neural aspects of addiction, often overlooking the crucial interoceptive dimension, the perception of internal bodily states. Even though evidence suggests that physiological states contribute to the development and persistence of addiction, and patients report intense bodily sensations during craving episodes, we still lack tools to measure bodily processes associated with craving, understand their role in addiction risk, and effectively address them in therapy.Through a transdiagnostic and multidisciplinary approach, I will address the interoceptive basis of craving. Work Package 1 involves experimental craving induction and self-administration procedures in non-clinical alcohol and tobacco users to establish how interoceptive processes influence the motivation to consume substances and contribute to escalation in substance use severity. Work Package 2 extends this research to real-world settings using Ecological Momentary Assessment (EMA) in patients diagnosed with alcohol and tobacco use disorder. By integrating real-time data on craving, stress, and interoception into network analyses, I aim to identify interoceptive markers predictive of craving and relapse. Finally, a randomized controlled trial will test the effectiveness of incorporating individualized interoceptive feedback generated from EMA data into cognitive-behavioral therapy.By focusing on the bodily dimension of craving and relief, this approach brings novel perspectives to the aetiology of addictive disorders and can yield breakthrough interoception-based treatments that can improve thera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hierarchical multifunctional composites with thermoelectrically powered autonomous structural health monitoring for the aviation industry' to be submitted under Horizon 2020.

assistant: **Abstract**

HARVEST will unleash the potential of breakthrough technologies by creating integrated multifunctional systems for Aeronautics via the development of i) Structural composites, comprised of hierarchical carbon fiber (CF) reinforcements and an innovative thermoset 3R (repair, recycle and reprocess) epoxy matrix with ThermoElectric Generation (TEG) and self-repair capabilities, ii) Autonomously TEG -driven integrated systems for on- and off-line structural health monitoring-(SHM) and iii) Wired and low-power wireless SHM data transmission and mining system. The innovative intelligent materials and parts, will be manufactured in purposefully developed pilot lines aiming at reducing production time and costs. CFs yarns or textiles will be coated with nanomaterials using facile & environmentally friendly deposition and doping methods in a Roll-to-Roll (R2R) pilot line targeting dramatically increased TEG performance compared to existing composites, carbon and organic based materials. Innovative TEG-hierarchical composites will be manufactured with new generation 3R thermoset matrix systems enabling out of autoclave manufacturing and self-repair. These will be interfaced with a purposely designed hardware to (i) power inherent functionalities (e.g. strain, damage or UV-exposure sensing), (ii) drive external elements (e.g. piezo electric sensors for SHM) and (iii) transmit sensing signals to a remote panel. The autonomous SHM systems will increase the safety of civil aviation; reduce emissions and maintenance & life cycle costs. The proposed technologies will be finally integrated in two aircraft demonstrator parts, targeting areas with temperature gradients (e.g. engine vs. environment, inside vs. outside fuselage during flight) or where quick heat dissipation is essential (e.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A wearable miniaturized fall detection system for the elderly' (FALLWATCH).

assistant: **Innovation**

Falls among the elderly occur frequently. Approximately 30% of people over 65 fall accidentally each year, and for those over 80 this rate raises up to 50%. Falls are an important factor in the health limitations of the elderly due to a high morbidity caused by physical and psychological consequences, loss of independence and even death. Late or non existing responses cause 2 million persons having to be hospitalized and approximately 85000 deaths can be attributed each year to this fact. There are a number of alarm devices trying to satisfy the need of an early intervention in case of fall, but existing fall detectors do not have a remarkable social impact neither a significant market penetration: just 4.5% of Europe's potential end users have any of the existing social alarms. Two facts hinder their effectiveness of the existing fall detectors, capping therefore the market demand: bad ergonomics and lack of reliability. FallWatch project proposes a new generation fall detector device included in a whole fall detection system and is thought as an effective way of minimizing the consequences of falls in the elderly. FallWatch will automatically detect a fall and immediately contact the health services to allow an early intervention. FallWatch will produce, on the one hand, a miniaturized fall detector device of a scale reduction by 50% of existing devices, and on the other hand, biocompatible materials for the device’s package and for an adhesive patch to comfortably stick the device to the user’s skin. FallWatch system will solve the reliability problem by using both wearable device and environmental infra red sensors at the user’s home and developing a specific data fusion algorithm that will cross check the variables to avoid false alarms. In order to achieve the erg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aerogel European Supplying Unit for Space Applications' to be submitted under Seventh Framework.

assistant: **Abstract**

The main purpose of this project is to create an European Supplying Unit for one of the Critical Space Technologies for Europoean Strategic Non-Dependence, the advanced thermal control materials. Currently, the thermal protection of the hardware of spacecrafts is assured by underlying advanced thermal control materials, typically Multi Layer Insulations (MLI). One of the basic materials for MLI, the Kapton, is used in several thermal control applications and easily falls under access restrictions. In this project it is intended to develope the manufacturing technology for the material that is considered to be the next generation of thermal insulation in space, the aerogel. Aerogels are the materials with the greater potential to substitute MLI in thermal insulation of spacecrafts, due to its very low density, its veryt high thermal insulation efficiencies, the providing of the thermal insulation as single material that can be industrially producible and the tailorability for different applications. The combination of the know-how of the entities involved in the proposal, which cover the research and development of aerogels at a laboratory scale, the design and construction of semi-industrial equipments for aerogels manufacture, and the design, integration and qualification of thermal insulation materials inspace applications, will create tremendous synergies to put Europe in a front position as a supplier of the material that is likely to be the future of the thermal insulation in space. The collaborative efforts of the partners, which have already been working in the development of these systems in the last few years, is expected to allow establishing in Europe on a shor-term the required technical capabilities to supply aerogels for space applications, such as (re)-en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Templated Electro-Chemical Synthesis for Novel devices' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The overall goal of TECNO is to become an enabling technology for InSb-based devices on Si, which has numerous and wide-ranging applications, such as IR sensing, Majorana zero mode devices, and high-performance cryogenic amplifiers. For this purpose, I propose an innovative approach to template-assisted selective deposition. In the currently implemented integration technology at IBM, I will replace the semiconductor deposition process (MOCVD) by electrochemical methods. This will enable entirely new possibilities of integrating III-V semiconductors on silicon for sensing and quantum computing. TECNO will result in an solution-based technology for the preparation of high-quality multicomponent semiconductor materials and validate the proposed path by demonstrating functional electronic devices on silicon. The aim of the project is also to significantly expand my knowledge base and therefore amplify the impact of my research as well as my career prospects. TECNO ideally demonstrates the mutual overlap of typically quite separate fields, i.e. chemistry with solid state physics and device engineering. My deep expertise in electrochemistry perfectly matches the requirements of IBMs semiconductor interests and their integration technology. It is truly beneficial for both parties involved. IBM will benefit from my electrochemical solution expertise, while I will learn how to push my work to another level of maturity and impact in an industrial environment.


**Keywords:** monolithical integration on silicon, IR detector, CMOS, template-assisted deposition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Induced pluripotent stem cells for cardiomyocyte generation in mouse' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The scientific aim of InduHeart is to produce novel comparative information on the generation, maintenance, characteristics of iPS cells in mouse and on their differentiation towards the cardiac lineage. InduHeart will also employ mouse embryonic stem (ES) cell lines to develop innovative methods for the targeted preparation of differentiated cardiac muscle cells. The characteristics of cardiomyocytes generated from iPS and Embryonic Stem (ES) cells will be compared and their ability to report disease phenotypes and drug responses faithfully will be investigated. Technical focus will be generating a novel and potentially patentable technology in Europe for reprogramming somatic cells to an embryonic state without the use of viral constructs, which have a perceived risk for future cell based therapy. This will lead towards the generation of iPS cells in a more predictable, controlled and safer way than previously. Overall, the results are expected to provide novel information on the pathways and differentiation events leading to a high percentage of cardiomyocytes in the special supplement based mouse ES cell differentiation system.  These cardiomyocytes can serve also as useful tools for high-throughput screenings for pharmacological studies including efficacy, safety, and toxicology. InduHeart will contribute to the field of modern tissue engineering and regenerative medicine.