RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EGNSS high Accuracy SYstem improving PhotoVoltaic plants maintenance' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

EGNSS high Accuracy SYstem improving PhotoVoltaic plants maintenance.The purpose of the EASY PV proposal is to provide a time and cost effective service as direct response to the growing need expressed by several maintainers and PV field owners to enhance the energy production of their plants.As photovoltaic plants are aging, it is not uncommon that their production lowers due to inefficiency caused by unknown modules on the plant lowering the whole plant’s productivity. Thermal inspections are valuable for PV owners and maintainers, but relevant procedures (currently performed by operators with handheld cameras) are time demanding and sometimes expensive due to safety costs for the personnel involved in the operations (e.g.: PV modules on roofs, rough areas, …). It stands to reason that today such operations are not fully automated yet and the responsive recognition of a broken module might result very difficult in a large PV plant.As a first improved solution, the growing technology of RPAS (Remotely Piloted Aircraft Systems) is exploited to gather thermic images which are geo-referenced by GPS positioning and processed by computer vision algorithms. However this configuration is very respectful but still not enough in order to provide the required positioning accuracy for the automation and fast identification of the broken modules. Only the aid of accurate positioning allows a cost effective solution to reduce time, costs and risks for personnel involved: the added value provided by the employment of GNSS high accuracy solutions as novelty in the RPAS domain is the key driver for the EASY PV turnkey solution.Finally EASY PV solution is conceived to build up an automatic system for acquiring, georeferencing and processing both visible and thermal images captured by a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms that maintain centromere DNA repeats stability in human cells.' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Cell division relies on centromeres, which connect chromosomes to the spindle for separating sister chromatids in mitosis. Human centromeres are composed of large arrays of repetitive DNA, which are often sites of aberrant rearrangements in cancer. While centromere defects can cause chromosomal instability, the molecular mechanisms that maintain their repetitive DNA stable are poorly understood. During the fellowship, I aim to investigate how human centromere stability is maintained and the consequences of centromere dysfunction in driving cancer and aging. To circumvent impeding technical barriers due to incomplete centromere sequence annotation, I have ideated the use of Chromosome Orientation Fluorescence In Situ Hybridization at human centromeres (Cen-CO-FISH; Giunta, 2018). Using this innovative technique, I revealed that CENP-A and CCAN (constitutive centromere-associated network) proteins prevent centromere instability, and this functionality is compromised in cancer cell lines and in primary cells undergoing senescence (Giunta & Funabiki, 2017); my data show that CENP-A may play a new role during centromere replication, preventing DNA damage, repeats shortening, and subsequent aneuploidy. I will use the Auxin-Inducible Degron (AID) system and CRISPR-Cas genome editing with high-throughput imaging of Cen-CO-FISH to identify the human centromere maintenance network and investigate the mechanisms of repeats stability. I will also examine the consequences of centromeres dysfunction, including changes in the size of the array, cell ploidy and proliferation dynamics, using a variety of validated and novel methods, including Cen-qRT-PCR, qFISH and cytogenetic assays. Altogether, the proposed research will unveil a novel conceptual framework to explain the fragility of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional and evolutionary studies of the glutamatergic synapse; a proteomic and genetic approach' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Glutamatergic neurons are the main excitatory nerve cells in the central nervous system of mammals, in this project we aim to better understand the molecular composition of their synapses. We are particularly interested in the post synapse and the complexes of proteins associated to the NMDA glutamate receptor. We are focused in this set of molecules since the NMDA receptor is central for the establishment of synaptic plasticity, a physiological property of neurons which is believed to be necessary for learning and memory, the cognitive process we are interested in. The general objectives of this project are three:  1. Understanding the molecular basis of learning and memory through combined genetic and proteomic approaches. 2. Understanding the evolution of the synapse by studying species differences. 3. Characterising the human hippocampal glutamatergic synapse.   These objectives will be addressed using a combination of proteomic and bioinformatic systems biology. In all cases we will isolate the protein complexes of interest and investigate its molecular composition by mass spectrometry. For the first objective we want to compare wild type mice with a series of KO for important proteins in learning and memory; we expect to better understand the role of the KO molecules in those cognitive processes. We also want to study the evolution of the glutamatergic synapse; we propose to characterize the same set of protein complexes that we studied in mice in other species, especially in humans. We believe that evolutionary studies will be a way to work out the important proteins for higher cognitive functions and we hope to describe the human synapse composition for the first time. Neurobiology is a very important field of science and it will be much more for the years to co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'New Urbanism vs Compact City: Investigation of the relationships between urban micro- and macro- scale effects on travel behaviour'.

assistant: **Objectives**

Urban sprawl and excessive car use are two critical threats for the sustainability of contemporary cities. Two main planning approaches have so far been proposed to address these phenomena: The “New Urbanism” and the “Compact City”. One of the main criteria was their environmental effectiveness, especially on transport. Thus, a considerable number of studies focused on the relationship between urban form and travel choices. The main difference is that in US the focus was mainly on the relation between urban micro-scale characteristics (road network structure, bicycle and pedestrian infrastructure, urban furniture, density at the neighbourhood level, local accessibility) and travel behaviour, while in Europe most studies focused on urban macro-scale (city density, distance to center, land use mix). The paradox, however, is that although policies and plans at both scales (micro-US, macro-Europe) have been promoted, the phenomena continue to expand on both continents. Could the interventions in only one spatial level lead to significant changes of travel behaviour? Should the interventions be directed towards both spatial levels simultaneously? What is the optimal mix between urban micro- and macro- scale policies for a sustainable urban perspective? Which are the parameters that affect this ideal balance of planning policies? The proposed research will investigate through quantitative and qualitative methods the effects of urban macro- and micro- scale characteristics on travel behaviour in different urban environments (Europe and US) focusing on the structural relationships between the two spatial levels. To investigate this relationship, a new critical parameter is introduced: the action space of the alternative means. In a second level the aim is to translate these rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In African Communities of Practice (CoPs), international collaboration and the pursuit of scientific endeavour has faced a major barrier with the lack of access to e-Infrastructures and high performance network infrastructure enjoyed by European counterparts.  With AfricaConnect, the proposed AfricaConnect2 and regional developments, this situation is changing rapidly. In the project Teaming-up for exploiting e-Infrastructures' potential to boost RTDI in Africa (eI4Africa) it has been demonstrated clearly that it is possible to develop e-Infrastructures in Africa.  It has also been demonstrated clearly that, as with the rest of the world, easy to use web portals, or Science Gateways, are needed to help CoPs to easily access e-Infrastructure facilities and through these collaborate with CoPs across the world.  However, a major problem exists:  it is very difficult for non-experts to develop Science Gateways and supporting e-Infrastructures.  Elements of guides and supporting materials exist but these are either written for different audiences or out of date. This present Coordination and Support Action, called Energising Scientific Endeavour through Science Gateways and e-Infrastructures in Africa (Sci-GaIA), therefore proposes to bring together these materials into clearly structured guides and educational documents that can be used to train and support representatives of NRENs, CoPs and, importantly, Universities to develop Science Gateways and other e-Infrastructures services in Africa. Sci-GaIA plans to work with new and emerging CoPs to develop these exciting technologies, to strengthen e-Infrastructure service provision, especially in terms of open access linked data, and to deliver training and dissemination workshops.  This will give a sustainable foundation on w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The first utility-oriented, agnostic software platform for quantum-centric drug discovery' (KvasirAccelerator).

assistant: **Concept**

Humanity is exploring the limits of computing to solve the world’s biggest challenges with unprecedented speed and precision. While quantum hardware is being matured into a commercial technology, there is still no quantum software capable of addressing real business problems. Furthermore, quantum computing will inevitably exacerbate the complexity of current computational workflows for non-coding experts to extract knowledge. At Kvantify, we are developing Kvaser, the first platform-agnostic, explainable, customer-centric quantum software tool, to be operated by the end-user. With EIC funding, we will develop advanced algorithms for quantum chemistry and machine learning that will solve real-life drug R&D problems beyond the scope of classical resources. Kvaser will empower R&D scientists to run molecular and biochemical simulations on modern hardware with unmatched speed and accuracy, enabling high precision quantum chemistry calculations for efficient and accelerated drug discovery.


**Keywords:** Drug discovery,Computer sciences,Algorithms and complexity,Quantum computing,Big data,Life sciences R&D,Pharmaceutical R&D,Machine learning,Digital services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rational Bioactive Materials Design for Tissue Regeneration' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The development of functional materials for tissue regeneration is today mostly based on perceived and limited design criteria often using a single point approach with lengthy animal trials. The outcome after in-vitro and in-vivo evaluation is often disappointing resulting in a tedious iteration process. The main objective of this project is to achieve radical innovations in state-of-the-art biomaterials and to design highly performing bioinspired materials learning from natural processes. By this outcome driven project comprising first class academic and industrial participants the project will create scientific and technical excellence and through links with these SMEs will strengthen the technological capacity and their ability to operate competitively on an international market. BIODESIGN will (i) perform a careful retrospective-analysis of previous outcomes from clinical studies performed with humans through animal modelling in a reverse engineering approach applied to an in-vitro to the molecular design level, (ii) develop new strategies for a more rational design of ECM mimetic materials serving both as gels and load carrying scaffolds, (iii) link novel designs to adequate and more predictive in-vitro methods allowing significant reduction in development time and use of animals and (iv) evaluate these concepts for musculoskeletal and cardiac regeneration. By the development of safe, ethically and regulatory acceptable, and clinically applicable materials this project will promote harmonization while at the same time creating awareness in society of the benefits of these innovations as one of the key points is to improve health and quality of life of the patients. BIODESIGN will stimulate technological innovation, utilization of research results, transfer of knowl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spectroscopic and Computational Elucidation of Transition Metal Photoredox Mechanisms' (PhotoRedOx).

assistant: **Innovation**

Photoredox catalysis is an emerging and powerful methodological approach for accomplishing bond constructions in organic chemistry and utilizes photosensitizers to convert photon energy into chemical potential to drive photo-induced C–C/C–X couplings and C–H bond activations. Given catalysis can be light-activated, this methodology is considered environmentally friendly and sustainable. To date, the three main modes of action are: 1) single electron transfers (SETs) to initiate radical coupling reactions; 2) SETs to simultaneously generate free radicals and activate transition metal catalysis (i.e., dual photoredox); and 3) energy transfer to or direct excitation of a transition metal catalyst. While the number and complexity of bond transformations is rapidly increasing, there are few spectroscopic or computational studies of photoredox mechanisms, largely due to the complexity and interplay between excited state dynamics and reactive intermediates. The applicant will use a variety of high-level spectroscopies spanning 10 orders of magnitude in photon energy and 15 orders of magnitude in time to observe molecular events from femtoseconds after light absorption to individual steps in the reaction. Experimental data guide ligand design to tune ground and excited state structure, regioselectivity, or alter reactivity for new bond constructions. Together, the methodologies allow to evaluate energetics of reaction coordinates, define mechanisms, estimate redox activity of intermediates, and map excited state potential energy surfaces to define key electronic contributions from frontier molecular orbitals. This work will be communicated at local, national, and international seminars and conferences. Major findings will be disseminated via publication in high-impact scientifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GRID programming with COMPonents: an advanced component platform for an effective invisible grid' (GridComp).

assistant: **Concept**

GridComp main goal is the design and implementation of a component based framework suitable to support the development of efficient grid applications. The framework will implement a kind of invisible grid" concept as it will properly abstract all those specific grid related implementation details that usually require high programming efforts to be dealt with. The proposed framework represents an alternative to existing component frameworks in at least three aspects: - it raises the level of abstraction perceived by programmers, by providing hierarchically composable components and advanced, interactive/integrated development environments, thus enabling faster and more effective grid application development processes,- it implements advanced component (self-) management features, implementing well known or experimental techniques that actually temper the efforts required to programmers to design, implement and tune efficient grid applications,- it exploits knowledge from existing European projects as well as open source tools in its design and implementation, as the high level guidelines to design the component framework are directly inherited from CoreGRID NoE results and the framework itself is built on top of existing open source, European grid programming environments and it will be eventually released under open source license.The GridComp framework will be able to interoperate with existing standards, such as Web Services, thus providing the grid application programmers further chances to develop grid applications exploiting already existing software modules in a component perspective. The component model refined in GridComp will be designed to become a "de facto" standard: big industry and SME involvement in the project since the very beginning guarantees the fram
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'R&D Network Life Cycles' (RNDNET) under Seventh Framework.

assistant: **Objectives**

It is widely agreed that research and development (R&D), with its subsequent technological innovations, is the driving force in economic growth. R&D activities are distributed across different economic actors, notably firms, which interact in many ways, e.g. through collaboration or knowledge transfer. Using a conceptual network approach, these firms can be seen as nodes and their interactions as links of a network that may evolve over time, both with respect to the actors and their interactions. The goal of this project is to understand the evolution and performance of R&D networks. In doing so, the project wants to explain the formation of R&D networks as a purely endogenous phenomenon, emerging from the behavior of individual firms. Many studies have been devoted to the investigation of the consequences of a certain R&D network structure on a firm's performance. However, only little is known about the time evolution of this structure, or the antecedents of this evolution. Emphasizing temporal aspects, this proposal focuses both on the relationship between the structure of an R&D network and its performance, on an individual firm and aggregate industry level, and on the dynamics of network creation and evolution.