RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mechanisms of antigen presentation in central nervous system autoimmune disease' (2002-2006).

assistant: **Innovation**

Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system (CNS) that is believed to result from the activation of auto-reactive T lymphocytes. Experimental autoimmune encephalitis (EAE) models of MS have been developed and demonstrate a role for CD4 T cells.However, current ideas about disease pathogenesis suggest a critical role for CNS antigen-specific CD8 T cells. I propose to establish a CD8 T cell mediated mouse model of EAE to address several critical unknowns: How does the immune system become exposed to CNS antigen (e.g. myelin basic protein, MBP)? What are the cellular and molecular determinants that result in T cell tolerance (the inactivation of T cells specific to CNS antigen) versus T cell activation (inflammatory responses that drive CNS autoimmunity)? Evidence suggests that the antigen presenting cells responsible for capturing and presenting CNS antigens may be dendritic cells (DCs). Based on clinical observations, I hypothesize that CD4 T cells serve as triggers causing auto-reactive CD8 T cells to become reactive instead of tolerant.The proposed studies differ from my previous research experiences in that they involve immunology and rely heavily on techniques specific to this field, whereas my former work has been primarily in biophysics and lipid chemistry. Training in the lab of a leader in DC immunology and cross-presentation at a world-renowned institution will provide me the skill set needed to advance my career interests and help me fulfil my desire to lead an independent group, combining my interests in CNS immunology and neuro-pharmacology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spatiotemporal dynamics of secondary metabolism in the ocean microbiome' to be submitted under Horizon Europe.

assistant: **Abstract**

Microbial secondary metabolism (SM) is critical to ecological interactions because it is a source of bioactive products such as antibiotics and anti-cancer drugs. Marine microbes are prolific sources of these compounds. Until now, the prospection of biosynthetic gene clusters has primarily focused on cataloguing SM diversity by using machine learning (ML) tools, with little regard to their importance for the microbial dynamics. Microbes benefit from SM by providing a chemical language for inter-specific communication and improving environmental interaction. The dynamics and evolutionary aspects of this interaction, as well as its effects on spatiotemporal microbial dynamics, have not been studied due to a lack of suitable datasets. To elucidate this, the SPADYN-SM project aims to investigate the spatiotemporal  dynamics of SM in the ocean microbiome using an innovative genome-resolved work frame to verify diversity, mutations, selection pressures, and effects on environmental variables in a collection of metagenomes from monthly marine samples collected by the host and collaborators over a 7-years period. Dr. Santos will combine his unique expertise in biochemistry, molecular biology, bioinformatics, and ML with the host's notorious experience in microbial ecology and evolution to document the fluctuation of SM in marine microbes for the first time on an unprecedented temporal scale. SPADYN-SM could lead to a better understanding of seasonal patterns of SM in marine microbes, environmental effects, and possible impacts on microbial evolution. SPADYN-SM continues to advocate for the analysis of polymorphisms at the protein structure level, which may lead to the discovery of novel drug-like compounds. This highly interdisciplinary project, with its international collabora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Genomic integrated force for type ii diabetes' (GIFT), addressing dissemination and exploitation.

assistant: **Impact**

More than 35 millions of Europeans are expected to develop Type II Diabetes by the year 2010. This challenge merits a multinational effort espoused in this application;(a) GIFT assembles a range of interdisciplinary expertise;(b) GIFT participants have a long history of fruitful international collaborations;(c) analysis of different populations is a useful tool to identify etiological genes, characterise the role of causing variants and genes/environment interactions, which may improve public health care. GIFT seeks to develop an exiting Genomic Integrated Force, aiming the improvement of genomic approaches in complex traits, using Type II Diabetes as a paradigm for multifactorial conditions. GIFT could have economic impacts by reducing massive health care, disability and social costs and by promoting biotechnology and pharmaceutical industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effects of Climate Change on Air Pollution Impacts and Response Strategies for European Ecosystems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ÉCLAIRE investigates the ways in which climate change alters the threat of air pollution on European land ecosystems including soils. Based on field observations, experimental data and models, it establishes new flux, concentration and dose-response relationships, as a basis to inform future European policies.Starting with biosphere-atmosphere exchange measurements, ÉCLAIRE quantifies how global warming and altered precipitation will affect emissions of key European primary pollutants (NOx, NH3, VOCs), including interactions with increasing aerosol and hemispheric O3 background concentrations, modifying atmospheric transport and deposition. An ensemble of chemistry transport models will be applied to assess uncertainty in response to harmonized scenarios for climate, emissions and land-use, while high resolution studies will investigate how climate change alters local patterns of pollutant exposure and threshold exceedance.A network of European experiments for contrasting ecosystems and climates, combined with meta-analysis of unpublished datasets, will quantify how climate change alters ecosystem vulnerability to tropospheric O3 and N deposition, including interaction with increased CO2. Combined with special topics on interactions with N form (wet/dry, NHx/NOy), aerosol-exacerbated drought stress and BVOC self-protection of O3 effects, novel threshold and dose-response approaches will be developed. These will be combined with regional atmospheric and biogeochemical models to estimate interactions and feedbacks on plant/soil carbon stocks, greenhouse gas balance and plant species change.The new risk assessment chain to be developed will be applied at the European scale, quantifying how projected climate change will alter damage estimates. Combined with economic valuati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synthetic Cellularity via Protocell Design and Chemical Construction', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We propose to undertake an ambitious 5-year multidisciplinary programme that seeks to pioneer and establish a fundamentally new paradigm in protolife research that is based on novel conceptual and experimental advances in the design and construction of rudimentary forms of synthetic cell-like micro-ensembles (protocells). Our approach is positioned at the interface between materials chemistry, soft matter science and synthetic biology, and will address the following aspects of protocell design and construction: (i) functional complexity in protocell phenotypes, (ii) protocell self-structuring and metamorphosis, (iii) multi-compartmentalization and protocell endosymbiosis, and (iv) collective behavior in protocell communities. We will initiate unprecedented increases in the complexity of individual protocells by developing new types of structural architectures with advanced functions including photosynthetic protocells and motile proteinosomes, and develop innovative strategies for the chemical secretion of spatially extended extra-protocellular hydrogel matrices and induction of protocell metamorphosis. We will develop a modular micro-engineering approach to protocell multi-compartmentalization with the aim of generating coordinated enzyme- and gene-activated endosymbiotic interactions, and pioneer the experimental study of collective behaviour in communities of synthetic protocells. Our overall aim is to pioneer a modern approach to synthetic cellularity that advances the chemical and physical basis of protocell structure and function, and spearheads the development of future technologies based on autonomously functioning chemical micro-compartments with applications in bioinspired micro-storage and delivery, micro-reactor technologies, cytomimetic engineering, and the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Language policies and attitudes in Quebec' to be submitted under Seventh Framework.

assistant: **Abstract**

This application is for a year's worth of fieldwork in Montreal, Canada. The project is part of the applicant’s larger post-doctoral research, which investigates the interaction between official language policies and their impact on language use at the grassroots in three political entities: Singapore, Wales, and Quebec. The three locations feature different types of top-down language policies and planning, with various different languages involved in the process, English being the common player. Thus, officially quadrilingual Singapore has extensively promoted English, whereas Wales has a much more laissez-faire attitude to the language, and Quebec has taken far-reaching steps to limit its use. The research on Singapore and Wales is well underway, but the Quebec component requires detailed on-site fieldwork. The proposed project will see data collection in the realms of public displays of linguistic practice (so-called 'linguistic landscaping'), of language attitudes, and, using standard sociolinguistic methodology, of actual language use in practice. A physical presence in the province is required to obtain an in-depth picture of these elements; the city of Montreal being particularly well-suited due to its high proportion of Anglophone residents, who are the primary source of informants. The results from this project will not only inform current trends in policy perception, but also contribute to a comparative approach to the issue of language policy and language attitudes, an approach that has so far been lacking.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles'.

assistant: **Concept**

RNA-based therapeutics, including siRNA, miRNA, mRNA and CRISPR/Cas9 components, have unprecedented therapeutic potential and hold the promise of treating any disease with a genetic component. However, inefficient delivery into diseased cells hinders their clinical progress. Consequently, there is an urgent need for novel, original approaches to overcome the delivery challenges.Recently, an endogenous RNA transport system has emerged, based on the release and uptake of extracellular vesicles (EVs). EVs are naturally equipped to transfer RNA molecules to other cells in a functional and selective manner. Furthermore, I have recently demonstrated that EVs deliver RNA more efficiently than state-of-the-art synthetic RNA nanocarriers. Thus, EVs hold promise as a new paradigm for RNA delivery. However, the mechanisms underlying EV-mediated RNA transfer are unknown, and reproducible methods for efficient loading of EVs with therapeutic RNA are lacking.The aim of my proposal is to (1) elucidate the mechanisms underlying EV internalization and processing that lead to the functional delivery of their RNA content and (2) radically improve the loading efficiency of EVs for therapeutic RNA delivery. To realize this, I will:1) Identify genes and pathways involved in EV-mediated RNA transfer using a novel CRISPR/Cas9-based RNA delivery reporter system.2) Systematically compare uptake and intracellular trafficking of EVs and synthetic nanocarriers.3) Design a novel and improved method to load EVs with therapeutic RNA.4) Demonstrate the effect of EV-mediated delivery of therapeutic RNA in a murine model of myocardial infarction.The outcome of this research will fundamentally advance our understanding of the cellular processes enabling EV-mediated RNA transfer, which is of crucial import
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HYDROGEN ECONOMY BENEFITS AND RISKS: TOOLS DEVELOPMENT AND POLICIES IMPLEMENTATION TO MITIGATE POSSIBLE CLIMATE IMPACTS' under Horizon Europe.

assistant: **Concept**

Hydrogen is undoubtely the most talked-about carbon-free energy vector. However, policymakers and citizens that are supporting hydrogen large-scale penetration in the energy sector should not only be aware of the evident benefits but also of potential safety and climatic risks driven by a long term hydrogen-based economy. HYDRA will start from the evaluation of policies and directives on hydrogen technologies to derive the actual penetration rate of H2 in the market, and evaluate atmospheric emissions of hydrogen and other gases linked to production processes or leakages. The project will then model socio-economic and energy scenarios, considering land use and water consumption, due to the future deployment of a hydrogen economy. The possible impact on the atmosphere will be assessed, considering the interaction of H2 with the oxidizing cycles of CH4, CO, N2O, and O3, and the possible increase in water vapor concentrations, finally estimating the overall radiative forcing. HYDRA will also assess the possible contribution of soil in removing H2 from the atmosphere. Climatic projections will simulate possible climate change scenarios caused by the hydrogen economy, to which HYDRA will respond proposing guidlines and mitigation actions. Finally, since hydrogen-air mixes are highly imflammable and H2 leakages can represent a serious safety issue along the whole value chain, HYDRA will develop a remote-control monitoring tool. The HYDRA tool will detect and quantify hydrogen leakages to increase the saefty of hydrogen-based technologies and prevent unecessary emissions to the atmosphere. The monitoring system will also be able to detect emissions of other gases, so that also possible impurities can be taken into account. The monitoring tool will be tested in a facility where
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Quantum simulation of transport properties in arbitrary shaped potential landscapes with ultracold bosonic atoms'.

assistant: **Objectives**

In solid state systems transport experiments are among the most important probes to investigate the properties of different phases of matter. A number of intriguing observations have been reported where the interaction between the charge carriers plays a significant role. One of the most prominent examples currently explored in the laboratories are high-Tc superconductors and fractional-quantum-Hall insulators. Quantum-mechanical systems whose properties are governed by the interaction between its constituents are computationally difficult to handle. In most cases numerical results can only be obtained for small systems or in reduced dimensions. One possibility to overcome these limitations is to perform analog quantum simulations with ultracold atoms. The basic idea behind these experiments is to built artificial model systems using the bottom-up approach: Bosonic and fermionic atoms are cooled to ultra-low temperatures to reach quantum degeneracy. Subsequently the atoms are confined in engineered magnetic and optical potentials realizing closed quantum systems that are, to a good approximation, decoupled from their environment. This approach has the advantage that the system parameters such as interactions, dimensionality, geometry or the amount of disorder can be controlled externally and even varied dynamically. The rapid progress in this research area makes them promising candidates to provide stimulating input on current condensed matter problems. It initiated a whole new field known as atomtronics, which aims at designing electronic-like circuits with potentially interesting applications. Recently developed techniques allow for an engineering of tailored trapping geometries and high-resolution imaging, which provides new insight in the study of quantum transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Toxic Free metallization process for plastic surfaces' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Technological advancement has significantly transformed plating methods by introducing metal coatings on plastic substrates. Plating on plastics (PoP) has emerged as an effective solution in a wide range of applications in the automotive, aerospace and home appliances industry. There is a high preference for plating on plastic in the automotive industry, owing to its light weight, cost effectiveness and corrosion resistance. In the automotive industry, it not only adds aesthetic value but also helps in increasing fuel efficiency by reducing the overall vehicle weight. Decorative chrome, copper and nickel plating is quite popular on various interior and exterior plastic parts such as knobs, handles, logos, emblems, trims, etc. ABS, PC, PET, Nylon, and PEEK are widely used polymers in plastic plating.However, the current processes for PoP present some significant disadvantages related to environmental sustainability, occupational safety and quality of coatings i.e the use of hexevalent chromium in the etching process and the use of Palladium in the activation step. FreeMe project proposes two revolutionaries approaches for the metallization of polymeric (plastic or resins) surfaces without the use of hexavalent chromium and palladium. The first technology is based on the use of resins (e.g. epoxy-acrylate resins) with the additions of suitable nickel based precursors. This composite resin can be deposited uniformly in the surface of the plastic object either by spray deposition methods or other simple deposition methods. The nickel precursors are afterwards reduced utilizing appropriate reduction agents (e.g. NaBH4) creating the necessary nuclei for the next step of electroless deposition for the formation of the conductive layer.


**Keywords:** Plating on Plastics, Etch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ATM system safety criticality Raises Issues in Balancing Actors responsibility' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

ARIBA will assess certification issues for ground ATM systems and operational procedures and intend to produce templates which could benefit the present ongoing and planned certification activities in Europe. Full use will be made of the ample knowledge the ARIBA partners have in 1) certification practices from air transport and other areas (high finance, nuclear, rail transport, space), 2) rationales underlying the ATM safety regulation developments in UK and France, 3) ATM safety related studies (e.g. DAAS, MUFTIS, SECAM, RHEA, GENOVA and TOSCA-II), and 4) state-of-the-art safety assessment and safety management developments. ARIBA will keep things practical by focusing its attention around the following major technological ATM enhancements:- Space-based navigation and surveillance,- Advanced ATC automation support tools,- Flightplan exchange through air-ground data link. For these enhancements two distinct, but inter-related issues need be solved prior to operational introduction: System Safety Validation and Arrangement of Responsibilities. %