RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Gene therapy of inherited retinal diseases' (EYEGET) targeting Horizon 2020.

assistant: **Abstract**

Inherited retinal degenerations (IRDs) are a major cause of blindness worldwide. IRD patients witness inexorable progressive vision loss as no therapy is currently available. In the last decade my group has significantly contributed to a change of this scenario by developing efficient adeno-associated viral (AAV) vectors for retinal gene therapy that are safe and effective in humans. The objective of EYEGET (EYE GEne Therapy) is to overcome some of the current major limitations in the field of retinal gene therapy to expand initial therapeutic successes to a larger number of IRDs. To achieve this, we propose to use four parallel, highly innovative and complementary approaches: i. expansion of the limited AAV cargo capacity by a novel methodology based on co-administration of multiple AAVs that reassemble in target retinal cells and reconstitute large genes; ii. targeting of frequent dominant gain-of-function mutations that cause RP using state-of-the-art AAV-mediated genome editing technologies; iii. induction of retinal cells clearance of toxic IRD products by AAV-mediated activation of autophagy and lysosomal function; iv. development of methodologies to directly convert fibroblasts to photoreceptors that can be transplanted in retinas from IRD patients with advanced PR loss and for whom in vivo gene therapy is no longer an option. We will use a combination of in vitro and in vivo state-of-the-art technologies including novel AAV vector design, high content screening of drugs that enhance AAV transduction, genome editing, and advanced in vivo retinal phenotyping to obtain proof-of-concept for each of these therapeutic strategies. The results from this study may impact the quality of life of millions of people worldwide by providing a cure based on gene and/or cell the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploiting HPCN in an engineering consultancy environment' to be submitted under Fourth Framework.

assistant: **Abstract**

Reverse Engineering Ltd (REL), an engineering consultancy firm using numerical simulation tools, have obvious HPCN requirements, but are unable to justify the large capital costs of purchasing high end equipment. Typical uses are the numerical simulations of the responses of structures to blast impact and explosive loading. Applications for this work include the development of side impact safety systems for vehicles, and the qualification and decommissioning of offshore structures. The main objectives of the project are: To show how existing hardware resources can be utilised more efficiently by exploiting high performance networking. To investigate the usefulness of European broadband networks for improving working practices and increasing the throughput of work. To investigate the usefulness of visualisation environments for embedded computational steering of remote simulations. The results of the experiments will be reduced execution times for existing numerical simulations and the ability to run larger simulations which more accurately capture the physics of the problems. Through dissemination and training activities, the results of the project will promote the use of HPCN amongst engineering firms within Europe encouraging them to improve their competitiveness. In addition, through REL's client base the results will be disseminated into different market sectors throughout Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ECVP/ESVP Summer School in Veterinary Pathology' under Sixth Framework.

assistant: **Concept**

Veterinary pathologists play key roles in health and welfare of man and animals. They contribute vital expertise to a wide range of fields, particularly food safety, monitoring of animal health and welfare, diagnosis of new emerging diseases, animal models for human diseases and development of new drugs for novel therapies of animal and human diseases. Their contribution is increasingly requested in wildlife conservation and epidemiological studies and in studies on wildlife as indicators of environmental health. Continued progress in these fields is essential for the EU population and has important economic consequences in the EU and globally. The European standard of veterinary pathology research, however, has in the past not been harmonised and careers developed only within national frameworks, culminating in an uneven level of training of researchers in the field. At the same time, a world-wide dearth of experienced researchers in veterinary pathology is observed, which places a severe constraint on scientific programmes in both academia and industry and represents a general societal problem due to the impact on human and animal health and welfare.Addressing these issues, the European College and Society of Veterinary Pathologists are jointly establishing a series of four annual, high standard research training courses, comprising training for 80 young researchers in core skills and latest research techniques in veterinary pathology. The programme incorporates lectures, practicals, self-assessment and discussions, complemented by training in problem solving and complementary skills, provided by internationally renowned scientists from academia and industry. The project will:(1) establish a harmonised Europe-wide high standard research training in veterinary patholog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revolutionary vaccines to prevent pandemic and seasonal outbreaks of respiratory viral infections: The best-in-class UNIVERSAL multi-season influenza vaccine' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

While an ongoing pandemic outbreak of coronavirus (COVID-19) is having enormous impact on global societies, a quest for effective vaccination becomes of unprecedented importance to save lives and economies globally. Symptomatic flu, another respiratory RNA viral infection, affects ~10% of global population every year and leads to regular pandemic outbreaks. Existing prophylactic vaccination requires updates each flu season or pandemic outbreak, and has a strikingly limited efficacy (40% on average, as low as 9% in elderly). This is mainly due to a rapid mutation rate of surface viral proteins that are targeted by the current vaccines. Governments, institutions and vaccine community urgently seek for a universal flu vaccine that would provide a multi-season protection against all seasonal and emerging pandemic viral strains.  OSIVAX, a French clinical stage innovative biotech, strives to develop vaccines able to prevent respiratory viral infections across multiple seasons and outbreak. OSIVAX has developed OVX836, a best-in-class, game-changing universal flu vaccine candidate. OVX836 is based on oligoDOM®, a proprietary immune-boosting technology that triggers powerful, targeted and durable immune responses involving activation of specific immune response killing infected cells. OVX836 circumvents the need for annual vaccination updates by targeting an intraviral protein that is highly conserved across all influenza strains. OVX836 has a potential to disrupt the flu vaccine market currently dominated by single-season vaccines. The revolutionary universal flu vaccine is predicted to have a blockbuster potential (>€2.5 billion). OSIVAX’s experienced team aims to get OVX836 ready for the clinical proof-of-efficacy milestone (Phase IIb) that will position the company for >€5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of the analytic fundamental group via differential methods' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content  The aim of the research is to study the analytic fun- damental group of punctured disc imbedded in the rigid analytic variety associated to the affine line over a p-adic field.  A better understanding of this group is required, if we want to find a good category of etale analytic coefficient sheaves, which would be stable under the usual six coho- mological operations. and moreover would be preserved by the itale Fourier transform (which I defined first in my PhD thesis and studied subsequently in the paper cited in the detailed research proposal). The method proposed is to associate to any padic lisse itale sheaf, a certain p-adic differential equation, in a func- torial way. This idea is due originally to J.M. Fontaine, who implemented it in the case of padic representations of local fields, and asked for a global analogue of his construction. Training conlent (obyive, benefit and expecteJ impact)  For the completion of the project, I will need to get acquainted with a variety of techniques, such as Faltings's work on the mysterious functor, Fontaine-Laffaille's theory and with the work of Christol-Mehbkout on the index of padic differential equations, to name a few.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Electronic commerce for a high level organisation of European sales'.

assistant: **Concept**

According to the market requirements to stop relocation abroad and to face new competitors, the main weapon will be based on the capability of the short-term reaction provided to European textile and clothing companies. Proximity to their market gives these companies a basic advantage compared with East Asian firms for which distance and delivery time are incompressible. Thus, for the European textile and clothing industry, the solution lies in the Quick Response Service thanks to a reorganisation based on demand forecasting and automation of information exchanges.E.C.H.O.E.S ultimate objective consists in the reduction of the time needed to make available any model in any outlet thanks to a better reactivity given to textile and clothing sector. It means that interaction between the partners of the Textile and Clothing chain must be improved, changing the current situation based on traditional means (Mail, Phone, Fax) into an interconnected system in which each link of the chain becomes sometimes a Customer, sometimes a Supplier.E.C.H.O.E.S project aims at developing a Decision Aid Facility composed of three technical goals.A Customer/Supplier Server, based on a standard common language and on the use of INTER/EXTRANET communication, will be developed to automatise the commercial dialogue.The setting up of commercial relationships (open Marketplace) between firms not yet involved in business dealings will be implemented on a Central Server. The development of this Central Server will mainly require the realisation of an intelligent search engine customised for the textile and clothing sector.A forecasting model, based on orders from sales outlets as well as real consumer purchases, will be implemented on the Central Server.Such Decision Aid Facility will not be efficen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Totally renewable, environmentally enhanced products, lifecyclewide adapted to sustainability targets'.

assistant: **Objectives**

This proposal is prepared with the help of an Exploratory Award which included a Research Feasibility Study. The project is aimed at the utilisation of a new material that allows to manufacture Products without shape restriction out of a renewable and biodegradable raw material, processing full automatically with conventional injection moulding machines. Fasal, a biodegradable composite which consists of 60% wood chips, 30% grinded corn, 10 % natural resin and additives has potency to - break the market for biodegradable products with added value. - be a serious alternative for some wooden products in respect to production (energy and waste) and use of free forms. - convert the production waste of wooden products (from toys to timber) into a valuable raw material Although non complicated sample products have been successfully produced as shown in the research feasibility study, more research is needed to - adapt product and mould design to the known properties of Fasal - adapt Fasal to better mechanical properties (e.g. flexibility) - adapt Fasal products with means to improve the water resistance The major risk lies in the uncertainty of the material behaviour of the final products under user conditions. This can be caught up by an appropriate choice of application fields that utilise the new biodegradable thermoplastic material within its basic characteristics, taking advantage of the positive properties and considering the restrictions of the material. This will be the task of the Design Handbook. Starting points for the project are the existing material prototypes for Fasal (F 134, F197) and the knowledge about variability of properties, processing and experience in mould adaptation and sample production. Proceeding on the promising results of the feasibility study
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Atomic-scale Photochemistry' (AETHER).

assistant: **Concept**

Photochemistry entails natural and artificial reactions that are activated optically, and is at the heart of fundamental processes such as photosynthesis, vision, polymerization, catalysis, or energy conversion Innovative approaches to gain control over photochemical reactions that relied on macro- and mesoscale manipulations of light (e.g., chemistry in an optical cavity, plasmon-enhanced reactions, etc.) were reported recently, but no strategy was proposed to address the photochemistry of a molecule with atomic-scale precision. AETHER aims to provide a disruptive photochemical method whose fundamental concept is based on the manipulation of light with ultimate spatial accuracy. This approach relies on the confinement of a laser excitation  pulsed or continuous  into an extremely small volume at the apex of a scanning probe tip, eventually acting as a plasmonic picocavity. This confined electromagnetic field can then be moved on top of organic structures where it locally generates photo reactions. AETHER aims at addressing questions in a wide range of fields related to physical chemistry: -Can one generate photochemical reactions in a sub-unit of a molecule while preserving the rest of it? Can one use this site-specific approach to synthesize new molecular species?-To what extent can we deepen our understanding of fundamental natural processes (e.g., energy transfer, photo-isomerization) at play, for example, in photosynthesis and vision?-Can we combine this atomic-scale optical approach with time-resolved techniques to follow photochemical reactions in real time and real space?Answering these questions requires probing, manipulating, and exciting molecules with atomic and sub-picosecond precisions. To this end, a scanning probe microscope associated with laser excitat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The interaction of thiols and thiyl radicals with DNA model systems' (DNA-PROTDAM).

assistant: **Concept**

Thiols (RSH) play an important role in the living cells taking part in the chemical repair reactions of radical damages induced in DNA. As the result of such repair thiyl radicals (RS) are formed. The aim of this project is to broaden the knowledge concer ning kinetics of chemical repair reactions of nucleobase derived radicals by thiols. Moreover, to study in detail photosensitized generation of thiyl radicals from thiols and their possible interaction with unsaturated bonds in purines. In continuation of the former RTN project, by means of pulse radiolysis behaviour of the nucleobase-derived radicals with defined structures in the presence of thiols will be investigated. On this basis the repair rate constants will be determined. Photosensitized generation of thiyl radicals will be studied by laser flash photolysis technique. Behaviour of thiyl radicals in the presence of purines will be observed in order to answer the question whether thiyl radicals interact with unsaturated bonds in purine bases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Transforming industrial agrichemical research through the development of novel chemical tools and technologies to investigate molecular interactions'.

assistant: **Innovation**

The increasing world population, predicted to rise to 9 billion by 2050, will make huge demands on the agricultural biotechnology industry with respect to the development of agrichemicals that are able to drive and sustain increases in the production of food and fibre from plants, whilst mitigating competition for water and land use. The Foresight report on Global Food and Farming Futures (2011), the most comprehensive food security study to date, involved more than 400 leading experts from 35 different countries who concluded that the current global food system is failing. This landmark document highlighted that targeted investment in agricultural research and innovation was crucial in order to increase the yield and climate resilience of food crop production.At the heart of the proposed strategy is the need to train a new generation of multidisciplinary researchers who are able to work at the interface of the Plant and Physical Sciences - a cohort who will underpin the development of novel tools and technologies that are able to provide molecular insight into the mode of action of agrichemicals.The NexGenAgriChem IDP framework directly addresses this training challenge, and will transform the landscape of rational agrichemical design by providing scientists with a toolkit to predict and probe the transport and distribution profiles of potential lead candidates (Delivery), as well as their mode of action (Destiny) within plants and pests at the molecular level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Technology transfer node of machine vision in Finland' in the context of a Fourth Framework call.

assistant: **Objectives**

TTNMV-SF focuses on dissemination of the results achieved in the national technology programme (Machine Vision 1992-1996) and the EU funded machine vision research. Finnish Automation Support Ltd. co-ordinated the national programme, where 80 companies and 13 research organisations worked together in 60 different projects.Our PST activities will bring machine vision technology to new industries and especially to SMEs. Demonstrations and Best Practice actions will convince the European wide industry of the viability of those young machine vision providers and their new products. Technology experts in research organisations support machine vision providers in upgrading their system capabilities with HPCN techniques.