RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European multidisciplinary ALS network identification to cure motor neuron degeneration' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Amyotrophic Lateral Sclerosis is one of the most devastating diseases in neurology affecting in Europe 50,000 individuals at any time, and causing around 10,000 deaths each year. ALS is characterized by progressive degeneration of motor neurons in brain and spinal cord leading to muscle weakness. ALS affects otherwise healthy people at any time in adulthood. The patient becomes paralyzed and dies as the result of respiratory failure on average 3 years after onset of symptoms. There is no cure for ALS. The only available drug (Riluzole) is marginally effective in extending the lifespan of ALS patients with 3 to 6 months.Despite recent scientific breakthroughs in the discovery of (1) multiple ALS associated genes, (2) evidence for metabolic dysregulation, (3) environmental risk factors, and (4) the protein TDP43 in aggregates of 95% of ALS patients, mechanistic models applicable to patients are still unknown. This shows that ALS can best be tackled through a systems biology approach which can only be achieved in a large integrative effort at the European level.Euro-MOTOR unites a multidisciplinary partnership of world-leading experts of clinicians, basic scientists and bioinformaticians, and is able to exploit excellent infrastructures for patient sampling, -omics platforms, disease modelling and bioinformatics. Euro-MOTOR will integrate large quantitative -omics data sets from new functional models and from patients in two prospective European, population-based inception cohorts. By leveraging on the variation in the multilevel -omics data, Euro-MOTOR aims to detect key genetic drivers of disease susceptibility/progression, while parametric modelling of the causal connections in identified molecular networks will generate a model of disease. Major findings will be valida
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Molecular Analysis of Synaptic Dysfunctions Underlying Human Intellectual Disabilities' in the context of a Seventh Framework call.

assistant: **Objectives**

Synapses of the central nervous system are the cellular structures mediating communication between neurons. Mouse mutations studies of synaptic proteins have shown how they ultimately modulate animal cognition and behavior. Furthermore, there is a growing body of data suggesting a central role of the synapse in neurodegenerative, mental and behavioral disorders. This project aims at understanding the synaptic molecular dysfunctions associated with intellectual disorders, particularly non-syndromic intellectual disability (NSID, formerly  non-syndromic mental retardation); by doing so it also aspires at learning on the molecular mechanisms behind cognition. The current proposal also attempts at identifying proteins that can become pharmacological targets to treat intellectual disability and to study to what extend mental disorders can be reverted after birth. Mouse models of most synaptic proteins associated with NSID are already available to the scientific community; these will be a key resource to the project. The goal of this research is to study the synapse as a whole biological system and to characterize the changes it undergoes due to disease. That is why proteomics and bioinformatics will be used to quantitatively analyze the synaptic proteome in control and model animals. With the disease-related molecular dysfunctions characterized it might be possible to identify pharmacological targets and to test drugs in the animal models to look for phenotypic recovery. Finally, to investigate the reversibility of NSID, genetic rescue experiments will be performed. These experiments will consist in re-introducing the wild type copy of the gene mutated in the animal model as a conditionally expressed transgene. The transgene expression can be triggered at different developme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Epigenetic regulation of economically important plant traits', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The mission of EpiTRAITS is to train young researchers in epigenetic gene regulation and flowering in the model plant Arabidopsis thaliana and the crop plants maize (Zea mays) and barley (Hordeum vulgare). Epigenetic gene regulation confers stability of gene expression patterns through cell divisions while allowing changes in expression in response to environmental or developmental cues. Although changes in epigenetic gene regulation are a major cause for trait variation, no rational strategies have been developed that utilize this knowledge for crop breeding purposes. EpiTRAITS will focus on one of the key plant traits, flowering, which is controlled by various epigenetic mechanisms. The scientific program aims to bridge the gap between fundamental and applied research by translating results from epigenetic research in model organisms to improved technologies for crop breeding and molecular diagnostic tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Promoting and facilitating ERA-networking between European Contract Research Organisations (C.R.O.)' (CRONET-DAYS) targeting Sixth Framework.

assistant: **Abstract**

The goal of the Specific Support Action CROnet-days is to facilitate and enhance the meeting between the Contract Research Organisations of European Research Area in Surface Transport Area (road, rail, waterborne, intermodality). It aims at : - enhancing t he creation of RD and Innovation projects in ERA - initiating european partnerships (FP6 Integrated Projects and Network of Excellence, Eureka, bi- or tri- national projects) - increasing technology transfert and synergies inter-CRO (sharing and combining knowledge, know-how, software, hardware, facilities, human ressources) - networking on common RD areas by enabling cross-fertilisation of ideas and capabilities between the different surface transport modes Contract Research Organisations are major actors of technology RD and innovation , but are too fragmented. Very few individual CROs or companies that can reasonably claim to respond to challenges in RD sector due to increasing complexity and interdisciplinarity critical mass. For this purpose, support fr om EC is needed to initiate the networking process, so to integrate CROs efficiently in European Research Area. Beneficials results are also expected to stimulate high tech and medium tech SMEs on specific niche technology through their participation in CR O network and partnership. This objective will be achieved by organising a two-days Surface Transport" CRO meeting in Nantes, including several general presentations, specific session on horizontal aspects (consortium agreement, intellectual property righ ts,...), as well as one to one technical and business sessions. Besides enhancing networking process, additional outcomes of this event will be an address book including numerous European CROs able to be active in the field of Surface Transport, and delive ry o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Entanglement Verification Enabling New Technologies'.

assistant: **Concept**

Quantum technology promises the next revolution in information processing and communication. Over recent years, the new flourishing research primitive – Quantum Information Science – has provided a rich framework for testing the foundations of quantum theory. Entanglement theory became a thriving research discipline because it was discovered that not only does entanglement question our fundamental understanding of the universe, but it also powers the majority of quantum information tasks.Quantum optics is a natural platform for investigating and implementing new quantum information tasks. Photonic entangled states are the ideal candidate to demonstrate such proposals because they are robust against decoherence, easily manipulated, and can be shared with little loss, either through free-space or in optical fibre. To date, the vast-majority of entangled states suffer from two major shortcomings: one, the exponentially bad scaling of large entangled state generation, and two, the post-selected nature of their observation. We tackle both these problems in this proposal.Photon production is solved through multiplexing and by using new state-of-the-art superconducting detectors gained through an international collaboration. Multiplexing is a promising technique that transforms non-deterministic events into near deterministic events. To multiplex entanglement, we need a heralded source of entangled photons. We build such a device, and temporally multiplex it to increase the probability of success using a room temperature Cesium Raman quantum memory.. With this device we will demonstrate the first experiment that faithfully teleports a single photon using a heralded entangled state. Our synchronized entanglement source will find applications in many future quantum information e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Suicide gene therapy in stem cell transplantation' under Fifth Framework.

assistant: **Concept**

The outcome of allergenic stem cell transplantation (allow-SCT), the treatment for haematological malignancies, is significantly limited by a severe and potentially life-threatening complication induced by donor lymphocytes, i.e. graft-vs. -Host disease (DVD). The aim of this 3-year pre-competitive project is the development, pre-clinical evaluation and exploitation in the clinical setting of an innovative therapeutic strategy for the transfer into donor lymphocytes of a suicide gene conferring sensitivity to a prod rug thus allowing their subsequent selective in vivo elimination and cure of DVD. New suicide and ranker genes, viral vectors and protocols for cell manipulation will be developed and rapidly transferred to industrial partners to prepare the exploitation in the clinical setting. Finally, clinical protocols using this strategy will be developed with the final goal of offering safer and more effective allow-SCT to a larger number of patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Universities, technology transfer and spin-off activities: academic entrepreneurship on the periphery of Europe' to be submitted under Fourth Framework.

assistant: **Abstract**

The objectives are to examine the growth and development of academic entrepreneurship within universities in the European Community (where academic entrepreneurship includes contract research, technical consultancy, patenting and licensing activities, as well as the creation of spin-off firms, by university staff).In particular, it will examine academic entrepreneurship in the context of regions at different stages of development, which will allow an examination to be made of the role of universities within different types of region, and a comparison with similar regions elsewhere. Three different 'types' of regions will be studied: 1. University in a rural region 2. University in traditional industrial region 3. University in 'growth' or economically prosperous region. The study will try to provide answers to the following research questions: - What is the role of academic entrepreneurship in the economic development of different types of regions in the EC ? - What are the general policies for developing academic entrepreneurship in the peripheral regions of Europe ? Do these vary by region ? - What are the process by which university-industry relationships are formed ? Do these vary by type of region, university and university-industry relationships ? - Does the university environment and overall strategy of the university affect the development of academic entrepreneurship and university-industry relationships ? Six workshops (Month 3,5; 7; 11,5; 15; 18,5; 22,5) and a final conference (Month 23,5) will be held to present cross country comparison reports and the final report. The results are expected to lead to specific policy initiatives at regional, national and European level, aiming to improve the technology transfer from universities to small technology-based fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Supercritical carbon dioxide processing technology for biodegradable polymers targeting medical applications' (PROTEC), addressing dissemination and exploitation.

assistant: **Impact**

This project will develop a highly innovative 'Supercritical fluid' processing technology that will enable European industries to develop and manufacture, in a highly controlled manner, advanced multifunctional biodegradable materials that posses consist ent and well defined physical and mechanical properties, chemical composition, porosity, and degradation profile. This technological advance will be realised through addressing the scientific and technological gap between fundamental academic research an d industry and through further developing advanced process control methodologies. The innovative processing technology developed within the project will also be designed to enable efficient integration with existing extrusion and injection moulding machi nes found throughout European industry. The key project objectives include: - The processing of porous biodegradable polymers that demonstrate significant weight reductions, but whilst retain the physical and mechanical properties of the compact materia l. - The processing of thermally and shear sensitive polymers, demonstrating significant improvements in the reduction of degradation during processing, without induced foaming. - To establish the fundamental relationship between the injection moulding variables and the surface and interior properties of the material, and to establish the parameters that lead to process control. - To achieve process control of the materials biodegradation profile. - To achieve scale-up and application of the processin g technology, with consistent and reliable process control. - To establish the limitations of material design due to the degradation that occurs during sterilisation, and to identify sterilisation best practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanoscale Chemical Reactions Studied with In-Situ Transmission Electron Microscopy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Great successes have been achieved in nanoscience where the development of functional properties and the assembly of nanostructures into nanomaterials have become increasingly important. In general, both the tuning of the chemical and physical properties and the self-assembly of nanocrystals into 2D or 3D superstructures take place in a liquid environment. When analysing the structural properties of nanocrystals using Transmission Electron Microscopy (TEM), this liquid environment is contained between membranes to keep it in the high vacuum. At present, the thickness of the liquid is not controlled, which renders standard imaging at atomic resolution impossible. Here I propose to integrate micro-electromechanical actuator functionalities in the Liquid Cell chips to overcome this problem so that real-time atomic resolution imaging and chemical analysis on nanoparticles in solution becomes a reality. This new in-situ technology will elucidate what really happens during chemical reactions, and will thereby enable the development of new nanomaterials for optoelectronics, lighting, and catalysis. Oriented attachment processes and self-assembly of nanoparticles, which are key to the large-scale production of 2D and 3D nanomaterials, can also be followed in the Liquid Cell. Furthermore, the hydration of nanoscale model systems of earth materials such as magnesia, alumina, and calcium oxide is of major importance in the geosciences.  In the field of enhanced oil recovery, for example, the huge volumetric expansion that comes with the hydration of these minerals could facilitate access to reservoirs. My research group has extensive experience in in-situ TEM and recently has achieved significant successes in Liquid Cell studies. We are in an ideal position to develop this new tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Application of single electron devices for the development of a current standard'.

assistant: **Concept**

Quality assurance and traceability of electrical measurements are of fundamental importance for Europe's measurement infrastructure. To support the industrial technological progress, it is therefore of importance that the ampere, which is a base unit of the SI system, is directly realized with great precision and reproducibility. It is believed that such a standard can be realized using single electron devices. For a successful realization of a future standard it is necessary to enhance the effectiveness of the national research activities by means of international collaboration.The SETamp project aims for the realization of the following objectives: (1) to realize a thorough understanding of the physical processes that affect the performance of single electron tunnelling (SET) devices; (2) to coordinate and structure the device fabrication and testing;(3) to develope and test high-precision electrical-current measurement techniques.A general objective incorporated in the above mentioned objectives is to coordinate the interaction between theoretical, fabrication, and experimental research.(1) Theory: The work on the understanding of the physical processes that determine the performance of single electron devices has started with an experts workshop organized by DFM. The workshop took place from July 24 to 26 in Lyngby (Denmark). (2) Device fabrication and testing: The fabrication and testing of the first devices have been completed, and will be continued in the next period (PTB, NMi, CTH, SP, OFMET). There are some (inherent) setbacks due to malfunction of necessary equipment (OI). These problems have been solved satisfactorily by shifting work to other partners.(3) Current measurement: The development cryogenic capacitors and current comparators is on schedule and som
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Pre-normative work on sampling and testing of solid biofuels for the development of quality management (BIONORM)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Standards are seen as a major measure to develop the markets for solid bio fuels to achieve the environmental, social and agricultural goals of the Commission. On this background the aim of the BioNorm project is to work out a quality assurance system for solid bio fuels to help to develop the bio fuel market. This will be based on extensive work on sampling (i.e. investigations of the sampling errors and the sample reduction errors) and the testing of physical-mechanical fuel characteristics (i.e. moisture content & bulk density, ash melting behaviour, particle size distribution & particle dimensions, durability and raw density of pellets & briquettes) and chemical fuel characteristics (i.e. sulphur & chlorine content, major & minor elements). The results of this work will contribute to the work of CEN TC 335 Solid Biofuels". To ensure a successful project progress an Advisory Board will be installed."