RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eurolegalphil', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The European Union is the result of a long on-going process of co-operation and integration between states. In this process, member states have been gradually delegating part of their sovereignty to independent institutions that represent the community interests as much as the national and citizenship interests. As an institutional structure, the European Union is a good instrument to achieve the aims it pursues, aims such as stimulating economic and social progress, confirming the European identity in the international sphere, shaping a single European citizenship, and developing a context for liberty, security and justice.Yet, the European Union is still a fragile structure that faces problems of articulation and justification as far as it represents an effort to reconcile different systems, interests, values, and cultures. This process of integration opens the door to new intellectual challenges that legal philosophy -as a discipline that reflects and elaborates on our legal and social institutions- explains and evaluates.The three projected PhD Euroconferences aim at exploring these challenges and assessing their impact within three fundamental fields that usually concentrate the attention of legal philosophy: political philosophy, legal theory, and ethics. The first conference focuses on the globalisation phenomenon and its consequences for both the subsistence of democracy and the maintenance of cultural diversity in Europe. The second conference analyses which challenges the integration of different legal systems into a single European law poses to the judiciary, the institution responsible for the application of the European law. Finally, the third conference intends to subject our institutions and the phenomenon of scientific progress to an ethical reflection f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sociolinguistic Patterns and multi-Lingual INTERactions on the PAHOTURI river' to be submitted under Horizon Europe.

assistant: **Abstract**

It is widely assumed that languages in contact will tend to converge, either lexically, structurally or both. Multilingual speech practices drive the convergence: multilinguals economize cognitive resources by importing lexical items and grammatical structures from one language to another, gradually causing the languages they speak to become more alike. However, recent research suggests that the relationship between convergence and language contact is contingent on social context. Social environments that encourage the use of dialect or language to signal group identity and language ideologies that promote the selection of specific lexical items and linguistic structures as markers for social differentiation can drive divergence between languages in contact. Divergence under contact remains controversial as it implies that the deliberate cultivation of linguistic differences by multilingual speakers can cause dialects or languages to diverge, contradicting a common assumption that language change proceeds unconsciously. In general, actual multilingual competencies and speech practices remain underdescribed in such societies. What is required is a more detailed documentation and analysis of multilingual interactions so that the processes that underlie contact-induced divergence can be observed in practice.This project seeks to fill this gap in our understanding by documenting and analyzing in detail language use in three multilingual villages of the Pahoturi ethnolinguistic group of Papua New Guinea, where contact-induced divergence has been used to explain linguistic diversity. It seeks to document and investigate the relationship between sociocultural variables, language acquisition trajectories, language ideology and multilingual speech practices. The general predicti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Semantic Sensor Grids for Rapid Application Development for Environmental Management' (SemsorGrid4Env) targeting Seventh Framework.

assistant: **Abstract**

Sensor networks promise to bridge the gap that, for too long, has separated computing applications from the physical world that they model and in which they are ultimately embedded. Sensor networks are and will continue to be important in environmental management. However, many scientific and technological challenges need to be tackled before sensor networks are exploited in their full capacity for aiding decision support for environmental applications. This project addresses two of these challenges: (a) the development of an integrated information space where new sensor networks can be easily discovered and integrated with existing ones and possibly other data sources (e.g., historical databases), and (b) the rapid development of flexible and user-centric environmental decision support systems that use data from multiple, autonomous, independently deployed sensor networks and other applications.<br/>To address this challenge, the SemsorGrid4Env project will investigate and develop technological infrastructure for the rapid prototyping and development of open, large-scale Semantic Sensor Grids for environmental management. In particular, SemsorGrid4Env will enable:1. A semantically-consistent view of several heterogeneous sensor networks as a global Grid data resource;2. Rapid development of Grid services that combine real-world real-time data, coming from autonomous, heterogeneous sensor networks, with legacy historical data;3. Rapid development of open, flexible, contextual knowledge-based thin applications (e.g., mashups) for environmental management.<br/>As more and more sensor networks are independently developed and deployed, the SemsorGrid4Env outcomes will leverage their use of sensor networks in environmental management scenarios that were not foreseen or that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Induction of specific and indefinite tolerance to alloantigens and/or primarily vascularized allografts by DNA-mediated gene transfer' to be submitted under Fourth Framework.

assistant: **Abstract**

The main objective of this experimental project is to induce and maintain specific and indefinite tolerance to alloantigens and/or primarily vascularized allografts by DNA mediated gene transfer. In order to induce allotolerance, genes encoding cytokines or second-signal blockers and/or MHC molecules will be transfected either in the organ itself prior to grafting or in recipient bone marrow and stem cells by using and comparing the efficiency of three gene vectors i.e. adenovirus, retrovirus and liposomes. The ultimate goal of the project is to develop innovative therapies for inducing tolerance in human allograft transplantation. The importance of these intercellular mediators (cytokines such as TGF-Beta, IL-4 and IL-10), co-stimulatory (CD28/B7-1.2), apoptotic (Fas/Fas-L) or MHC molecules in the T cell response suggests that the expression of these proteins which regulate the immune response, at a high level locally in the allograft itself or in recipient bone marrow and stem cells prior to grafting might prolong the graft survival and/or induce specific tolerance to allograft. The following complementary experiments based on the latest developments in Transplantation Immunology are proposed: I) Transfection of the graft itself by viral or non viral vectors expressing genes encoding (1) down-regulating cytokines such as IL-4, IL-10, TGF-beta; (2) blockers of co-stimulatory molecules such as CTLA-4Ig or (3) Apoptotic molecules such as FAS/FAS-L. A) viral vector Transfection of genes encoding (1) cytokines and/or (2) down-regulating factors such as CTLA_4Ig by adenoviral vector in rats (M.Dallman, London) B)NON-VIRAL VECTOR Transfection of genes encoding cytokines such as TGF-beta, IL-4 and IL-10 in miniatures swine by LIPOSOMAL VECTOR (M.Baru and P.Gianello, Brussels)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mitotis-induced entosis and its role in cancer' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Entosis is a recently discovered process of live cell engulfment in which one epithelial cell is completely internalised by another, forming a 'cell-in-cell' structure. The majority of engulfed cells are killed and digested by their host, in an unusual form of cellular cannibalism.  Entosis is commonly observed in human tumours and entotic cell killing represents a novel mode of tumour suppression.  Although cell-in-cell structures have been noted by pathologists for decades, the molecular and cellular mechanisms that drive entosis remain poorly understood. Further study of this emerging topic will advance our understanding of both cell and cancer biology.Entosis typically occurs under conditions of matrix detachment. However, I have discovered that mitosis can drive entosis in adherent cells (unpublished). The potential significance of this observation to cancer is striking, given the highly proliferative nature of cells within a tumour.  Entotic cell killing may provide a means to limit inappropriately dividing cells.  In the proposed work, we will pursue this novel finding by studying the:1) Molecular mechanisms that promote mitosis-induced entosis2) Biophysical changes which accompany mitosis to induce entosis (multidisciplinary, international collaboration)3) Occurrence and significance of mitosis-induced entosis in human cancer4) Relevance of entosis to anti-mitotic cancer therapiesThe host lab is one of a few groups globally with experience in studying entosis and the Babraham Institute provides a rich research environment, with state of the art equipment. I will bring my key preliminary data and >10 years experience in biochemical/cell biological studies to aid this work and transfer knowledge to my host. We will also work collaboratively with Dr Michael Overhol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Scalable Learning for Reproducibility in High-Dimensional Biomedical Signal Processing: A Robust Data Science Framework' (ScReeningData) under Horizon Europe.

assistant: **Objectives**

Data science has quickly expanded the boundaries of signal processing and statistical learning beyond their accustomed domains. Powerful and complex machine learning architectures have evolved to distinguish relevant information from randomness, artifacts and irrelevant data. However, existing learning frameworks lack computationally scalable, tractable, and robust methods for high-dimensional data. Consequently, discoveries, for example, in genomic data can be the result of coincidental findings that happen to reach statistical significance. As long as groundbreaking advances in biotechnology are not accompanied by appropriate learning frameworks, valuable efforts are spent on researching false positives. ScReeningData develops a coherent fast and scalable learning framework that jointly addresses the fundamental challenges of drastically reducing computational complexity, providing statistical and robustness guarantees, and quantifying reproducibility in large-scale and high-dimensional settings. An unprecedented approach is developed that builds upon very recent work of the PI. The underlying concept is to repeat randomized controlled experiments that use computer-generated fake variables as negative controls to trigger an early stopping of the learning algorithms, thereby mitigating the so-called curse of dimensionality. In contrast to existing methods, the proposed methods are completely tractable and scalable to ultra-high dimensions. The gains of developing advanced robust learning methods that are computed ultra-fast and with tight guarantees on the targeted rate of false positives are enormous. They lead to new reproducible discoveries that can be made with high statistical power. Due to the fundamental nature and the broad applicability of the proposed learnin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Anatomical and Functional Dissection of Neural Circuits in the Zebrafish Optic Tectum' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The optic tectum has emerged as a tractable visuomotor transformer, in which anatomical and functional studies can allow a better understanding of how behavior is controlled by neuronal circuits. We plan to examine the formation and function of the visual system in zebrafish larvae using in vivo time-lapse microscopy and state-of-the-art “connectomic” and “optogenetic” approaches to monitor and perturb neuronal activity. We will apply complementary cellular and molecular analyses to dissect this circuit and identify the neuronal substrate of visual behaviors. We will start by analyzing the function, development and connectivity of a newly characterized class of inhibitory interneurons located in the superficial part of the tectal neuropil named SINs (superficial inhibitory interneurons) that I have previously identified. Our work based on functional imaging has placed SINs at the center of a tectal micro-circuit for size tuning of visual stimuli. We will dissect this working model by analyzing the physiological properties of SINs. We also will investigate their development and connectivity at the level of single synapses by imaging these cells in vivo using fluorescent reporters in transgenic animals. We will then study how SINs migrate to their final position in the superficial tectum away from the zone where they are initially generated and how their processes direct tectal synaptic lamina formation. SINs are the only tectal cells expressing Reelin and we will analyze the role of this pathway in tectal development and proper synaptic lamination in the tectal neuropil. Our multidisciplinary approach aims to describe in great detail the formation and function of a neuronal circuit crucial for visual function, establishing this model for neural circuits studies in verteb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Small molecule cytokine conjugates for cancer treatment' to be submitted under Seventh Framework.

assistant: **Abstract**

Standard of care strategies for the treatment of cancer still relies heavily on non-specific radiation- and chemotherapy. They are commonly associated with severe toxicities and in many cases only offer limited benefit for the patient. The targeted delivery of radionuclides, cytotoxic drugs and proinflammatory cytokines into malignant tissue, on the other hand, can markedly improve the therapeutic index and overall efficacy of such substances. Whilst monoclonal antibodies are the most widely used delivery vehicles to date, we believe that small molecule ligands will offer improved targeting properties. Most importantly, depth of tumour penetration and tumour-to-blood distribution ratio after injection should be significantly superior. We therefore propose to systematically investigate the targeting performance of somatostatin receptor non-internalizing ligands for the targeted delivery of cytokines into somatostatin receptor-overexpressing tumours. This project aims at (1) developing a general chemical approach for building safe small molecule cytokine conjugates (SMCC) (2) demonstrate that a somatostatin antagonist, non-internalizing ligand can selectively accumulate in somatostatin receptor-overexpressing cancers and (3) when site-specifically conjugated to proinflammatory interleukin-12, these novel SMCC are highly effective for the treatment of acute myeloid leukaemia (AML).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Evolution of sperm conjugates: does sperm competition drive the cooperative behaviour of sperm?'.

assistant: **Objectives**

Sperm conjugates, where multiple sperm cells attach to each other and move as a group, have been described in a wide range of taxa and could have significant impacts on the fertilization process, but understanding of their function is limited. Effective sperm cooperation through these conjugates could have evolved as an adaptation to sperm competition between multiple males, but this hypothesis has not been tested in insects, which have some of the largest reported sperm conjugates in animals. Bushcrickets have been well studied regarding species-specific variation in the level of polyandry and sperm competition. Large sperm conjugates (‘spermatodesms’) are also a common feature of this taxon, making it an ideal system to test the link between sperm conjugates and sperm competition. I will investigate this connection using within-species approaches, with controlled mating trials and sperm staining, as well as phylogenetic controlled studies, testing the link between the level of polyandry and spermatodesm traits between species. Finally, guided by the insight from these results I will construct a theoretical model to gain understanding into selection pressures that may have led to the evolution of conjugated sperm. The results will significantly improve our understanding of the evolutionary importance of collaborative behaviour of sperm, which has been largely unstudied until now. My supervisor, Dr Jussi Lehtonen, is an internationally renowned researcher who is experienced in developing mathematical models on sexual selection and sperm competition. The project includes a secondment hosted by Prof. Leigh W. Simmons, a leading expert in insect sperm biology. I, the candidate, am an expert on behavioural ecology, experienced in conducting mating trials in bushcrickets and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SYnaptic MOlecular NEtworks for Bio-inspired Information Processing'.

assistant: **Concept**

The SYMONE long-term vision is to build multi-scale bio-/neuro-inspired systems interfacing/connecting molecular-scale devices to macroscopic systems for unconventional information processing with scalable neuromorphic architectures. The SYMONE computational substrate is a memristive/synaptic network controlled by a multi-terminal structure of input/output ports and internal gates embedded in a classical digital CMOS environment. The SYMONE goal is the exploration of a multiscale platform connecting molecular-scale devices into networks for the development and testing of synaptic devices and scalable neuromorphic architectures, and for investigating materials and components with new functionalities. The generic breakthrough concerns proof-of-concept of unconventional information processing involving flow of information via short-range interactions through a network of non-linear elements: switches, memristors/synapses. These will require several breakthroughs concerning the functionality of reasonably complex networks of simple components, and the fabrication of networks of devices, including self-assembly and multi-scale interfacing/contacting between such networks.Memristive networks are expected to solve unconventional computational problems, e.g. solving maze problems and implementing dynamic multiplexers. The overall SYMONE objectives are to implement 2D memristic arrays and networks, establish multi-scale electrical connections, and to demonstrate bio-inspired functional behaviour in such systems. On the experimental side, SYMONE will work with lithographically defined NxN arrays of proven individual memristive elements (Nanoparticle Organic Memory FETs (NOMFETs), as well as self-assembled nanoparticle (NP) networks (NPSAN) with functionalised NPs. The theoretical