RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular circuits of sex dimorphism in cardiometabolic traits and risk factors' (2021-2027).

assistant: **Concept**

Cardiometabolic traits and risk factors including cardiovascular diseases, type 2 diabetes, and hypertension are the leading causes of death worldwide. These conditions exhibit some degree of sex differences, including differences in incidence or prevalence, age of onset, severity, disease progression, susceptibility, response to treatment and pharmacological adverse events. Unfortunately, the reasons behind this sex dimorphism are largely unknown, hampering the realization of an effective personalized medicine. My project will focus on understanding the genetic and molecular components that differentially impact men and women. I will first carry out sex stratified genome-wide association studies for cardiovascular diseases, type 2 diabetes, hypertension and obesity using large population biobanks to evaluate the effects of known-genetic variants within each sex and to identify novel loci that may have been previously undetected. I will then use molecular quantitative trait loci (QTLs) to identify specific gene expression changes and proteins modulated by these variants and that are likely to be involved in sex-specific development of cardiometabolic traits and modulation of risk factors. I will then validate putative causal genes using Mendelian randomization approaches. This will lead to optimize therapeutics and find new drug target to perform equally well in males and females and will open the door to improve personalized and precision medicine in the near future.


**Keywords:** Sex differences, Mendelian randomization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-Material Thermoplastic high pressure Nitrogen Tanks for Aircraft' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

TRINITI aims at developing and demonstrating concepts and methodologies enabling the realization of an integrated multi-material airborne pressure vessel for longterm storage of nitrogen, in particular a halon-free fire extinguishing system employing water-mist and nitrogen. TRINITI’s tank has been conceived to fulfill technical requirements foreseen by the CfP e.g. very low permeation of gases, mechanical loads according to RTCA Do160 Rec. G, good fire-smoke-toxicity (FST) properties, survival of high temperatures, large temperature gradients, as well as resistance against various chemical media. Demonstration multi-material thermoplastic tanks will be fabricated through a combination of processes such as co-extrusion of thermoplastic materials to form a multi-layer and multifunctional thermoplastic material, followed by In-situ consolidation Laser-Assisted Automated Fiber Placement process. The application of highly performing thermoplastic materials combined with advanced automated and out-of autoclave technologies on the one hand will answer to the need for less consuming and faster manufacturing processes (1 stage process), while on the other hand it will ensure reduced weight of the tank, reduced operational costs as well as reduced fuel consumptions and emissions of an aircraft. TRINITI's linerless tank, thanks to the versatility of the Laser assisted AFP antropomorphic robot and possibility to use a dedicate simulation tool to optimise the design of the vessel, is expected to range not less than 10% lighter than their nearest Type IV tanks. A better weight-to-tank capacity ratio, however, is not the only advantage of the high pressure vessel, in fact a significant manufacturing cost flow reduction is expected mainly because the chain of manufacturing processes w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Rewiring gene regulatory circuits to enhance central nervous system repair' (EnhanceRegen).

assistant: **Innovation**

The mammalian central nervous system (CNS) is the epitome of complex cellular architecture. Still, it has a limited capacity to self-repair after an injury, which contrasts with the regenerative potential of the CNS in lower vertebrates. Regeneration unfolds by the orchestrated triggering of developmental gene expression programs after injury. These programs are under the control of dedicated regeneration enhancer elements, which grant adult cells transcriptional access to developmental genes. Neural stem cells in the mammalian CNS lack the gene regulatory circuits that dictate when and where to activate the expression of developmental genes for regeneration. Consequently, most of the cells lost to injury are never replaced.This proposal aims to rewire mammalian gene expression circuits to endow neural stem cells with the capacity to activate regenerative responses after injury. First, building on innovative technologies, some of which that I developed, we will identify injury-responsive enhancer elements in the mouse spinal cord with single cell and spatiotemporal resolution. Then, using machine learning, we will decode the rules of injury-sensing DNA elements to design synthetic injury-responsive enhancers for precise gene expression control in neural stem cells. Finally, we will use synthetic enhancers in therapeutically relevant gene delivery systems to rewire gene circuits in order to promote the recruitment resident stem cells for cell replacement through the reactivation of developmental genes that would otherwise remain silent.The proposed research will uncover basic principles of gene regulation after CNS injury and open new avenues for the design of smart gene therapies for regenerative medicine using synthetic regeneration enhancers.


**Keywords:** Spinal co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Assistive Technology Rapid Integration & Construction Set' (AsTeRICS).

assistant: **Innovation**

More than 2,6 million people in Europe have problems with their upper limbs and therefore many of them depend on Assistive Technologies (AT). As the potential of the individual user is very specific, adaptive, ICT-based solutions are needed to let this population group participate in modern society. Such solutions are rarely available on today's market.AsTeRICS will provide a flexible and affordable construction set for realising user driven AT by combining emerging sensor techniques like Brain-Computer Interfaces and computer vision with basic actuators. People with reduced motor capabilities will get a flexible and adaptable technology at hand which enables them to access the Human-Machine-Interfaces (HMI) at the standard desktop but in particular also of embedded systems like mobile phones or smart home devices.AsTeRICS will implement a set of building blocks for the realisation of AT:\tSensors which allow the individual to exploit any controllable body or mind activity for interacting with HMI\tActuators for interfacing to standard IT, to embedded systems and to interact with the environment\tAn Embedded Computing Platform that can be configured to combine sensors and actuators to tailored AT-solutions which support the full potential of an individual userThe core of the software suite will be provided as Open Source. The complete system will be affordable for many people who cannot benefit from leading edge supportive tools today.AsTeRICS revolutionises the concept of AT: AT today mostly focuses on a certain task or situation. Due to the growing importance of the PC, AT has been oriented towards standard Human-Computer (HCI) or desktop interfaces. AsTeRICS respects the strong need for flexible, adaptable AT functionalities accompanying people with disabilities a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A combined post-genomics, biochemical and biophysical investigation to model the systems biology of embryo cell expansion and seed germination in Arabidopsis thaliana' under Seventh Framework.

assistant: **Concept**

The fellowship focuses on bringing a talented young researcher to a cutting edge systems biology institute in the EU to develop and utilize novel multidisciplinary approaches to better understand seed biology. Innovative imaging, biophysical and computational approaches in conjunction with the integration of post-genomics biology will be used to develop a multi-scale computational model describing the germination of seeds. This key plant developmental process is integral to agriculture and human existence, while the seed trade is worth over $30 billion annually. Novel genetic regulators of seed germination will be uncovered through the functional genomic validation of bioinformatic predictions based on gene interaction networks and machine learning algorithms. Prior to the expansion of cells in the embryo elongation zone, a localized accumulation of starch has been identified. This metabolite may provide the energy and solute necessary for cell expansion during germination, and manipulation of this pathway presents the opportunity to increase seed vigor and field performance. These hypotheses will be examined through the phenotypic characterization of seeds with altered starch synthesis and breakdown. The combined use of confocal microscopy and Atomic Force Microscopy will enable the biophysical properties of expanding embryo cells to be determined. These biophysical parameters will be integrated with their regulation by newly identified genetic regulators of germination and their modification by starch metabolism, leading to the development a multi-scale computational model describing seed germination. This model will significantly enhance our understanding of this developmental event and contribute to the production of higher quality seeds, increasing agricultural yie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Retrofit all-Electric Bus for reduced Operator Operating costs in urban Transport (REBOOT)' (REBOOT).

assistant: **Concept**

The REBOOT project aims to significantly improve the competitiveness of European urban bus operators through the development of a retrofit all-electric drive system that replaces diesel engines. The objectives of our project include:• To develop a retrofit all-electric drive system, battery and recharger pack for an 18 tonne bus that weighs less than 2.2 tonnes (the weight of a diesel drive) with the capacity to travel 160km  • A final system price of €120,000 that delivers a payback to the operator within 3 years• To deliver an 80% reduction in fuel operating cost for bus operators In Phase 1, our objectives include: • Conduct market sounding activities with at least 10 organisations comprising of customers, regulators and industry experts • Identify and establish strategic partnerships with at least 3 European industry partners in our value chain and 2 research institutions capable of enhancing the development and commercialisation of REBOOT• Identify and secure at least 1 location and operator for the pilot trial / demonstration of REBOOT • Evaluate an initial technology concept design using a design simulation package• Conduct a comprehensive review of the IP landscape and identify management strategies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Support Tool for Energy Efficiency pRogrammes in medical centres' (STEER).

assistant: **Concept**

To meet the greenhouse gas reduction targets set by the European Commission and to reduce the reliance on imported energy sources from not-EU countries, the energy efficiency sector vitally needs basic analytical and decision support tools. This is especially true for large scale energy-consumer plants (for ex. foundries) but also for medical centres which typically (1) use large amounts of energy, (2) run a wide number of energy consuming machinery with different electrical profiles, (3) serve a weak population that may be heavily affected by energy shortages, (4) have a continuous level of service with special periodicity and peak times, and (5) have to abide to all sorts of strict  regulations (for ex. special air quality requirements). The aim of this project is to create a tool that will provide medical centres and any other large institution involved in their energy efficiency programmes (governmental institutions, utilities providers, lending establishments, independent auditors, managers and technical staff), with information on the medical centre’s ideal energy consumption in different scenarios and on the most appropriate energy reduction plan for the medium-long term. The project’s primary proposal is to identity the main variables that are responsible for the energy consumption in medical centres and give to each of them a weight. A novel mathematical model will be produced which will reproduce energy consumption in given scenarios.On the basis of the above model, the project will proceed to build a scenario-based assessment and a prediction tool. It will be used by energy managers and decision makers to evaluate and compare future investments and actions to reduce energy consumption, also on the basis of their economic return. The acquired knowledge and exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Collaborative Process Automation Support using Service Level Agreements and Intelligent dynamic Agents in SME clusters', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

PANDA aims to speed up the integration process in the European ERP/CRM industry, by developing an advanced set of conceptual components and e-services dedicated to:(i) address current inefficiencies in the ERP/CRM value chain (ERP/CRM vendors, national representatives, consultants / dealers and end customers),(ii) facilitate efficient value chain operations and(iii) broaden opportunities for international e-collaborations (European clusters in ERP/CRM industry). PANDA's outcome will be an advanced B2B web-platform dedicated on serving the international value chain operations of the European ERP/CRM industry.To do so, PANDA will introduce the powerful notion of Request-Based Virtual Organisations (RBVOs) driven by the use of an innovative generation of sector specific Service Level Agreements (SLAs). RBVOs (flexible clusters reflecting the international ERP/CRM value chain) and SLAs (the regulating framework, among value chain members, for RBVOs operations) will be served by a community of Intelligent Agents (Multi-Agent System) that will be developed to orchestrate and automate SLAs empowerment and RBVO operations in a predefined, standardized and automatically generated manner. PANDA's components will be developed and integrated in a prototype web-platform. Prototype testing and validation will take advantage of PANDA's two large international `informal' clusters currently involving 2 ERP/CRM vendors, 200 ERP/CRM national reps and dealers, 50 IT consultants and 40.000 end customers in 7 European countries.The prototype's assessment will follow, based on a set of business, technological and operational metrics, while in parallel the deployment of a variety of dissemination and exploitation actions will target to spread knowledge on PANDA's activities and results through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Atomic-layer additive manufacturing for solar cells'.

assistant: **Concept**

The ALAMS project will provide the first application of ""atomic-layer additive manufacturing"" (ALAM), namely for the prototyping of solar cells in large arrays of microdevices. The ALAM concept combines the principles of additive manufacturing (3D printing) with the atomic resolution achieved by the thin coating technique atomic layer deposition (ALD). In ALD, atomic-level control is achieved by judiciously designing the surface reaction chemistry of molecular precursors at near-room temperature for it to become self-limiting. This renders experimental use of ALD very robust to a wide range of parameter variations, since the film growth occurs in a cyclic, layer-by-layer mode. This advantage will be exploited towards 3D printing, an area of application that ALD has never been used for until we built the first ALAM prototype in November2019. This prototype centers around a printhead that delivers the ALD precursors to the gas phase in the vicinity of the substrate surface, with a microfluidic element delivering a lateral resolution on the order of micrometers. The motion of the printhead with respect to the substrate allows the user to print lines and structures of arbitrarily chosen geometries, whereby each pass over a given point of the substrate adds to it exactly the amount of material corresponding to one ALD monolayer, that is, a thickness typically on the order of an atom, or 0.1 nanometer (depending on the exact ALD reaction used). After developing the ALD chemistry needed for ALAM of the materials required to generate photovoltaic stacks, the ALAMS PoC project will apply it to a case study, namely the rapid prototyping of solar cell microdevices in large arrays. The ALAM concept, however, is valid beyond the confines of photovoltaic research. Its commercial po
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'CO2 reconstruction over the last 100 Myr from novel geological archives' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

CO2 exerts a major control on Earth’s environment, including ocean acidity and global climate.  Human carbon emissions have elevated CO2 levels to above 400 ppm, substantially higher than at any time in the 800,000 year ice core record.  If we want to understand how Earth’s environment and climate will respond to a high CO2 world, we need to look deeper into the geological past.  This project provides a novel way to reconstruct ocean pH and atmospheric CO2 levels over the last 100 Myr.  This will allow us to fathom the fundamental mechanisms governing Earth’s environmental evolution, and improve predictions of environmental response to CO2 change in the future. Atmospheric CO2 and ocean pH are closely coupled, because CO2 is acidic and is readily exchanged between the ocean and atmosphere. If ocean pH is known, we can place strong constraints on atmospheric CO2. Thanks to recent developments in geochemistry, it is possible to reconstruct changes in ocean pH using the boron isotope composition (d11B) of fossil shells. The well-studied systematics of this method and its underlying thermodynamic framework provide confidence in its application to the geological record. However calculation of pH from carbonate d11B requires knowledge of the boron isotope composition of past seawater d11Bsw. Here I propose novel strategies and techniques with new or underutilized archives (evaporites, shallow carbonates, and infaunal foraminifera) to constrain this crucial parameter. With d11BSW constrained, new d11B records from benthic foraminifera will provide a 100 Myr record of ocean pH. This benchmark reconstruction will be used to test key hypotheses on major environmental change in the geological record, and to constrain atmospheric CO2 using a state-of-the-art biogeochemical model. T