RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional networks and cancer roles of the essential histone chaperone FACT' (SilentFACT), addressing dissemination and exploitation.

assistant: **Impact**

Our knowledge of the mechanisms underlying cancer rapidly evolves. Diagnosis and treatment are improving, but cancer remains an urgent health burden. Whole-genome sequencing of cancers by the International Cancer Genome Consortium reveals that a key driving force in the etiology of cancer is the abnormal expression of chromatin regulators. The SilentFACT project focuses on an essential regulator of chromatin structure, the histone chaperone FACT. Recently identified small molecules disrupt normal FACT functions, and cancer cells stop growing when FACT levels are reduced. This reveals FACT as an anti-cancer target. We will apply potent cutting-edge genomics, quantitative proteomics and biochemical approaches to systematically dissect and validate the functional networks, novel interactors and chromatin targeting mechanisms of FACT. We will then subject the identified major interactors to a small molecule screen targeting FACT in human cancer cells. This will occur during secondments to the chemical biology platform of the Curie Institute in Paris and at an industrial partner. The SilentFACT project supports a Polish chromatin researcher for two years research and training at Munich University. Our timely research, training and communication aims, as well as exchanges with the international research community, will markedly advance the chromatin field, determine how this essential protein complex is involved in cancer and advance the therapeutic potential of FACT- targeted small molecules. SilentFACT will establish a solid basis for drug development, and advance the researcher’s leadership, networking and employability, helping to establish an independent research program at this exciting interface between basic chromatin science and translational medicine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Molecular evidence for lifestyle habits'.

assistant: **Concept**

The World Health Organisation (WHO) is spearheading the promotion of healthy diets and increased physical activity as it claims that these are the leading factors affecting health and well-being in Western countries. This claim rests on numerous clinical studies which linked lifestyle-related factors (e.g. nutrition, physical activity, smoking) to good or bad health outcomes. Corresponding data are generally based on questionnaires, and the usefulness of these data strongly relies on the honesty of participants and how well they remember past exposures. However, it is known that when it comes to lifestyle, participants tend to overestimate habits that are generally considered as ‘good’ and, in turn, underestimate those that are considered as ‘bad’. There is thus a need for more objective research methods to measure these habits in order to gain better and more reliable insights in how they affect our health. Such methods can furthermore become valuable tools in clinical practice by contributing to the prevention or even treatment of diseases through lifestyle changes. In this project, I aim to identify low-molecular-weight compounds, including metabolites, nutrients, and toxicants, that associate with lifestyle-related parameters using state-of-the-art ‘metabolomics’ techniques. For promising compounds or compound combinations, I will then develop high-throughput, targeted methods and validate them according to regulatory standards. These methods can subsequently mature to clinical-grade laboratory tests which would help in cutting health care costs and improving health and well-being. At last, for the proposed work I will be carrying out an innovative project at a top-level European university. I will accordingly be granted the opportunity to gain new experiences, lear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons' (NANOPHYS).

assistant: **Innovation**

In the present proposal, we plan to examine the dendrites, axons, and presynaptic terminals of fast-spiking, parvalbumin-expressing GABAergic interneurons using subcellular patch-clamp methods pioneered by the PI, imaging techniques, and computational approaches.The goal is to obtain a quantitative nanophysiological picture of signaling in this key type of interneuron. By incorporating realistic BC models into dentate gyrus network models, we will be able to test the contribution of this important type of GABAergic interneuron to complex functions of the dentate gyrus, such as pattern separation, temporal deconvolution, and conversion from grid to place codes. The results may lay the basis for the development of new therapeutic strategies for treatment of diseases of the nervous system, targeting interneurons at subcellularly defined locations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neural mechanisms of action learning in mouse models' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The learning of novel skills is characterized by an initial stage of rapid improvement in performance, followed by a phase of more gradual improvements as the skills are automatized and performance asymptotes. Although the striatum has been implicated in skill learning, the detailed mechanisms and circuits underlying its role in the acquisition and consolidation of skills are not understood.  Using in vivo striatal recordings in mice we observed region-specific changes in neural activity during the different phases of skill learning. We verified using ex vivo recordings from medium spiny striatal neurons in brain slices of trained mice that the changes observed in vivo corresponded to long-lasting and training-specific changes in excitatory synaptic transmission in the striatum. Our preliminary data indicates that these changes may be differentially expressed in different output pathways of the striatum, i.e. in D2 receptor-expressing striatopalidal neurons (indirect pathway) versus D1-expressing striatonigral neurons (direct pathway). We propose to: 1) use BAC transgenic mice that express GFP in the direct or indirect pathway to discriminate if the long-lasting plasticity observed during acquisition and consolidation of a skill occurs preferentially in one of the pathways, 2) generate and use cell-type specific channelrodhopsin and halorodhopsin transgenic mice to investigate the involvement of the direct and indirect pathway in the acquisition and automatization of skills,  and 3) record in vivo from identified striatopallidal and striatonigral neurons, by means of either optogenetic stimulation, and determine if the direct and indirect pathway are differentially active during the acquisition and automatization of a skill. These experiments will help us understand the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pump Architecture Linked to Aircraft Cooling Expectations' (PALACE) under Horizon 2020.

assistant: **Objectives**

The PALACE project aims to develop a new generation of pump architecture for electrical machines cooling for aircrafts. It meets Clean Sky 2 (CFP03) objectives by significantly reducing weight, by increasing durability, and availability as required by aircraft manufacturers.The PALACE approach goes a step further, with a challenging objective of a 30% mass reduction, using non-conventional solutions, such as additive manufacturing processes, enabling hollow structures for some components of the pump. New coatings and new functional surfaces texturing will complete the design, with regards to friction, lubrication and thermal performances at the required very high speed conditions. Innovation in PALACE is not limited to new manufacturing processes but will rise up also from the combination of several design methodologies (Design For Manufacture and Assembly, tribology, topology and CETINNOV - a CETIM specific proven innovation methodology) along with a multi physics expertise. The multiphase Computational Fluid Dynamics - CFD models including oil cavitation, CFD tool shapes optimisation will address the high efficiency performances. PALACE will address the optimisation issue not only at the pump level but broaden the view at the whole cooling system level and make recommendations for more system optimisation.The consortium’s ambition is to develop a European, clean, robust and efficient pump architecture that will be implemented into most of systems of the More Electric Aircraft.  SERV (SME), as one of the few European aeronautic pump manufacturers, associated to CETIM, a mechanical research centre, have the competences and ambition to bring the PALACE pump to the European market. The project will lead to an ITAR free (International Traffic in Arms Regulations) export. P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamic Growth and Replication  in Coacervate Protocells' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Replication and division are two of the most fundamental properties of living systems. Without replication, Darwinian evolution would not be possible, and life could never have reached the degree of complexity we see today. However, exactly how mixtures of non-living molecules developed the ability to replicate and divide, remains one of the biggest mysteries in modern science. Various molecular replicators have been investigated previously, but they are all destined to become extinct by dilution, since they lack a surrounding compartment that divides spontaneously during replication.In this proposal, we aim at developing a new class of coacervate-based protocells that are capable of active growth and template-directed replication. The coacervates we propose here are condensed liquid droplets with a unique dual role: they act as a compartment that holds together and concentrates the template molecules and the building blocks, and they provide the right chemical environment for the replication reactions to take place at an appreciable rate. The coacervate-based protocells are composed of oligopeptides with low complexity sequences, inspired by the intrinsically disordered proteins found in membrane-free organelles inside cells. Active growth is achieved through fuel-driven reactions, either by elongation of existing peptides or by specific chemical modifications at the peptide side chains that enhance their coacervation potential. Longer peptides can also act as templates for conjugation of end-functionalized peptide fragments with sequence patterns complementary to the template. Protocells with sufficiently high growth or replication rates are not only stable against Ostwald ripening, but are also predicted to undergo spontaneous division through a shape instability. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Involvement of PKCgamma in long-lasting hyperalgesia induced by optiate analgesics' in the context of a Fifth Framework call.

assistant: **Objectives**

Using both behavioural and cellular approaches on PKCgamma knockout/wild-type mice, this project will evaluate the contribution of this enzyme in the delayed effects of fentanyl (hyperalgesia, tolerance, withdrawal, psychoaffective effects and cognitive deficits), an opiate analgesic widely used in human surgery.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'pHotonics ELectronics functional Integration on CMOS'.

assistant: **Concept**

Photonics on CMOS is a candidate technology for applications where functional integration is needed for improving system performance while reducing size and cost.Functional demonstration of basic building blocks such as a µlaser, a detector, coupling, and link has been realized in previous research projects. As a next step the HELIOS project proposes to integrate photonics components with integrated circuits as a joint effort of major players of the European CMOS Photonics community, in order to enable an integrated design and fabrication chain that can be transferred to EU manufacturers.The objective of the project HELIOS is to combine a photonic layer with a CMOS circuit by different innovative means, using microelectronics fabrication processes.<br/>Different types of activities are foreseen:\tDevelopment of specific, high performance building blocks: WDM sources by III-V/Si heterogeneous integration, fast modulators and detectors, passive circuits and packaging. It also includes the development of dedicated TIA and modulators drivers.\tBuilding and optimization of the whole food chain" to fabricate complex functional devices. Several components addressing different industrial needs will be built, including a 40Gb/s modulator, a 10x10 Gb/s transceiver, a Photonic QAM-10Gb/s wireless transmission system and a mixed analog and digital transceiver module for multifunction antennas.\tInvestigation of more promising but challenging alternative approaches. These concepts offer clear advantages in terms of integration on CMOS for the next generation of CMOS Photonics devices\tRoadmapping, dissemination and training, to strengthen the European research and industry in this field and to raise awareness of new users about the interest of CMOS Photonics.<br/>HELIOS will gat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Continuous Care' (C-CARE) under Fifth Framework.

assistant: **Objectives**

C-CARE intends to improve access to essential personal clinical data at any time by authorised healthcare professional having the need to know. To do this, it uses standard tools, namely XML. C-CARE, capitalising upon previous works, will specify a meta-thesaurus to describe and identify the information to insert in the different XML documents, stored on a server. Different Document Type Definitions (DTD) will meet the specific requirements of the different application domains. Each DTD will comprise a summary highlighting relevant aspects of a patient's condition. This information will be accessible to patients and healthcare professionals through secure access via the public data network. Thanks to Text-To-Speech (TTS) technology, medical data will be also accessible through PSTN and mobile phone networks. The C-CARE system will be validated in different clinical domains and countries in order to assess its potential impact on continuity of care and its multi-linguistic aspects.Objectives:C-CARE aims to develop tools in support of continuity of care by collecting and storing essential, relevant and up-to-date patient health-related information accessible to authorised users, patients included, any time anywhere, e.g., from the patient's home, from a vehicle on the road or from a hospital emergency department. C-CARE will give access to information through both standard Internet technology and traditional voice telephony, bridging the technological gap between different categories of potential users. Continuity of care is recognised as a key issue for improving quality and cost-effectiveness of healthcare. However the two extreme approaches i.e., a single, comprehensive and centralised EHR per patient or a virtual EHR physically scattered over a number of systems (GP,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DEVELOPMENT AND MARKET UPTAKE OF INNOVATIVE SYSTEM TO OBTAIN ELECTRICAL ENERGY FROM OCEAN WAVE RESOURCES' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The general objective of BUTTERFLY project will be focused on the development, demonstration and further commercialization of an efficient system that harvest the ocean energy from waves to produce cost-competitive and sustainable electricity. BUTTERFLY solution, is a Wave-To-Wire (W2W) system that aims to produce blue energy to be integrated with other renewables and traditional electrical supply of coastal regions. This innovative solution is composed of a Wave Energy Converters (WEC) that captures the energy from waves, and a Power Take-Off (PTO) system that converts the energy into electricity. The innovative character of BUTTTERFLY will maximise the capture and conversion efficiencies, providing affordable blue energy to coastal areas with good wave resources. This potential market includes coastal regions and big islands connected to the grid, but also small islands and remote coastal communities that are fully dependent on diesel generators for most of their energy requirements, being exposed to diesel fuel price volatility, frequent fuel spills and high operation and maintenance costs. This system will have the following features:- Lower investment per KW installed power than other ocean devices- Lower cost per kWh obtained than the other energy sources.- Sustainable energy production- No electricity generation in the sea- Continued and predictable energy supply- Easy to build, install and maintain- Customizable system for different type and size of waves- Achieve good levels of power quality- Wide replicability for islands and coastal regions- Contribution to the reduction of carbon footprint and emissions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fundamental Breakthrough in Detection of Atmospheric Free Radicals' in the context of a Horizon 2020 call.

assistant: **Objectives**

Atmospheric radicals, particularly hydroxyl (•OH) and nitrate radicals (•NO3), are the drivers of chemical processes that determine atmospheric composition and thus influence local and global air quality and climate. Current techniques for measuring radicals are based on spectroscopic and mass spectrometric methods, which are technically complex, cumbersome and expensive. As a result, the measurement of atmospheric radicals is far-from-routine and only a few research groups worldwide can perform them in a very limited number of geographic locations. There is therefore a clear need to develop new radical detection techniques which are much easier to implement and deploy than existing methods. The central aim of RADICAL is to develop and deliver the science and technology to electrically detect and quantify, for the first time, short lived •OH and •NO3 radicals in the atmosphere via new, low-cost and easily accessible Si junctionless nanowire transistor (Si JNT) devices. These devices will lead to improved monitoring and control of air quality and better predictions of climate change.Three breakthrough science and technology targets have been identified: 1) fabrication and functionalisation of arrays of Si JNTs for the selective and highly sensitive electrical detection of •OH and •NO3 radicals, 2) electrical detection of atmospheric •OH and •NO3 radicals under a range of laboratory conditions and 3) evaluation and validation of the radical detectors under realistic conditions in an atmospheric simulation chamber and via deployment in the ambient atmosphere.Expertise in electronics, computer modelling, materials and surface science, nanofabrication, radical chemistry and atmospheric science is integrated on a pan-European level to achieve the overall aim of the project. T