RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stent-based Sensing, Monitoring, And theRapy sysTem for Coronary Artery Diseases' (SMART-CAD).

assistant: **Concept**

In Europe, out of all types of cardiovascular diseases, coronary artery disease (CAD) is the most common cause of death (more than 40%). The leading cause of CAD is a blockage in the coronary artery due to plaque deposition. Balloon angioplasty and stenting are the two solutions used to treat CAD patients. However, in both treatments, restenosis (plaque re-deposition) occurs after a few months/years, and the only solution is to repeat the treatment to reopen the blocked artery. In the past, the scientific community has proposed many ways to monitor ISR; still, no research has suggested a feasibility study or stent-based treatment along with sensing and continuous monitoring. Motivated by the urgent need for new technological advancements to reduce the morbidity and mortality related to CAD (coronary artery disease), the proposed SMART-CAD project set out to develop a novel stent-based sensor for continuous sensing, monitoring and early treatment of the ISR (In-stent Restenosis). Here, a stent-based microwave sensor will be designed and implemented on the stent’s body to sense the development of the ISR, an RFID technology will assist in continuous monitoring of coronary artery health, and a microwave ablation will treat the plaque if ISR develops in the coronary artery. This will also help to boost the sustainable development goal target 3.4 (To reduce premature and preventable deaths in Europe due to cardiovascular diseases by 2030). The interdisciplinary nature of this project is strong, involving radiofrequency and microwave engineering, biomedical engineering, and biology. The results of this project will be helpful to the scientific community and medical device industry. This project will also strengthen the researcher’s academic profile and allow her to establish
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Cross-Disciplinary Alliance to Identify, PREdict and prePARe for Emerging Vector-Borne Diseases' (PREPARE4VBD).

assistant: **Innovation**

PREPARE4VBD builds on the conviction that a true shift in our ability for early detection, prediction and control of vector-borne diseases (VBDs) of both livestock and humans in Africa and Europe, can only come from advancing a deep cross-organismal understanding of the features that allow VBDs to persist in endemic areas. We will therefore “cast the net wide” focusing on several VBDs and vector groups to explore synergistic opportunities for integrated and cost-effective approaches to optimize surveillance, prevention and control of VBDs.Specifically, we will address three vector groups (mosquitoes, ticks and snails) and a range of their diverse VBDs (Rift Valley Fever, ehrlichiosis, theileriosis and fasciolosis), to advance a broad, conceptual knowledge reaching beyond specific VBDs. We believe that only through a better understanding of what enables theVBDs and vectors to persist in their areas of origin, how they manage to spread or what allows some VBDs to successfully span the entire global North-South climatic gradient – will we gain the insights and actionable knowledge that enables us to predict the potential of VBDs to spread and establish in new areas.PREPARE will establish a truly multidisciplinary network of partner institutions in Europe and Africa, including leading capacities in mosquito- tick- and snail-borne diseases of livestock and humans. The partners cover a wide range of disciplines such as vector ecology, molecular biology, bioinformatics, metagenomics, climate change and predictive spatio-temporal modelling, epidemiology and One Health. Our suggested approach is proactive, focusing on better prevention of tick-, mosquito- and snail-borne diseases of livestock and humans, by increasing disease knowledge in Africa, developing improved tools for ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Biochemical basis of rational vaccine design for induction of protective immunity'.

assistant: **Innovation**

The major objective of this proposal is to develop a new generation of more rationally designed vaccines against viruses and (virus-induced) cancer. The major vaccine targets are cytomegalovirus (CMV) and p53. Additional targets are human papillomavirus type 16 (HPV16) and hepatitis C virus (HCV). To achieve this overall objective a collaboration has been set up between 6 academic and research institutes and two European Vaccine companies (Pasteur-Mérieux and Biocine). In a multi-disciplinary approach partners 1,2 and 4-6 will collaborate to delineate the detailed rules for processing and presentation of MHC class I binding peptides. Subsequent steps analysed are 1) characterization of proteasome cleavage sites and specificity 2) mechanism and specificity of TAP-mediated transport from cytosol into endoplasmic reticulum 3) identification of best immunogenic peptides by MHC class I and class ll binding and stability assays followed by in-vitro response induction assays with human responding T-cells and immunization of HLA transgenic mice. Together the data obtained will be utilised to predict optimal MHC class I epitopes. A separate analysis, conducted in the laboratory of the coordinator, will yield information on optimal MHC class ll epitopes. This information will be used as building blocks of new vaccines and to monitor response against vaccines. Intact antigen-based vaccines and string of bead epitope-based vaccines will be tested in virus and tumor challenge/protection experiments in normal and HLA-transgenic animals in which antibody, T helper and CTL responses will be monitored. Various models of antigen delivery in the vaccines will be compared with respect to efficiency of protection and efficiency of T-cell response induction, including peptides or protein in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sperone Speroni and his Legacy (1508-1588). Literature, Philosophy and the Vernacular' (1508-1588).

assistant: **Concept**

This project centres on the intellectual biography and influence of Sperone Speroni (Padua, 1508–1588), one of the main Italian Renaissance promoters of studying Aristotle’s writings in the vernacular. Speroni, who for a time taught logic and philosophy at the University of Padua, maintained that philosophy should not be limited to Latin (the language of learned culture), but could just as easily be discussed in the language of the people. As the prince of the Academy of the Infiammati in Padua (1541), he required that lectures be delivered exclusively in Italian and exercised considerable influence on Alessandro Piccolomini and Torquato Tasso (among the most important figures in sixteenth-century Italian culture). His writings, particularly the Dialogo delle lingue, were also highly influential in France, including on Joachim Du Bellay’s Deffence et illustration de la langue françoise (1549)—that seminal work of French classicism—and on Claude Gruget, who translated the Dialogo into French (1551). Speroni symbolizes a new, evolving kind of literary figure: in his case, one who went from university professor to academy member to courtier in his later years. At the same time, his anti-humanistic programme proposed an attempt to mediate between high culture and consumer culture. Furthermore, Speroni acted as a model for professionalization and specialization within the field of literature, and particularly vernacular literature. This project aims to illuminate this original figure through a study of the contexts that marked his intellectual biography (university, academy, informal circles) and the Dialoghi (1542), including the work’s main themes (one very important one is that of language) and its descriptions of the main characters. A study of the dissemination of Spero
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Diagnosis, epidemiology of neospora caninum-associated bovine abortions (NEOSPORA CANINUM)'.

assistant: **Concept**

Infection with Neosporin canine, a protozoan parasite discovered only a few years ago, belongs now to the most frequently diagnosed causes of abortion in dairy cattle worldwide. In addition to abortions, N. canine infections in dairy cows may also be associated with premature culling and a loss in milk production. The objectives of the project are(1) to standardise and improve diagnostic methods,(2) to conduct epidemiological studies to assess risk factors for N. canine associated abortions, and(3) to study the economic impact of N. canine infections in various EU countries and to develop measures of disease control, including vaccination. These goals will be achieved by a close interdisciplinary co-operation of scientists (parapsychologists, biologists, veterinarians) involved in the development and evaluation of diagnostic techniques, with epidemiologists and bio-mathematicians.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Redefining the term 'Incubation Period' using large-scale digital data' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Infectious diseases pose one of the greatest risks for a global catastrophe. Just like controlling the spread of wildfires, an early detection of infectious diseases is instrumental to containing outbreaks. Nearly all infections start silently, and gradually progress until clinical symptoms appear. In this silent period, the incubation period (IP), pathogens inhibit major pathways of the innate immune system, allowing an extended period of unhindered replication. The rate of replication, as well as the type and length of suppressed symptoms vary considerably between pathogens, creating a unique signature for each pathogen. Thus, improved understanding of the IP is pivotal for early detection, prevention and control of infectious diseases. Previous studies estimating IPs have used aggregated retrospective data, and are subject to the biases of patient self-reporting. I hypothesise that the actual onset of clinical symptoms occurs earlier than previously known, can be identified more accurately, and can be used in real-time for patient empowerment. Focusing on respiratory infections, my methodological approach includes: 1) real-time evaluation of the prior risk for respiratory infections by integrating transmission models with individual-level data from electronic medical records of 4.5 Million individuals, 2) identification of micro-changes in patients’ behaviour during the early phase of an infection by prospectively analysing digital sensory data from wearable devices and mobile phones of 5000 selected participants, 3) early detection of the causing pathogen validated with self-swab kits that are tested using RT-PCR. Our preliminary work that combined an analysis of EMR and transmission modelling led to a change in public health policy in Israel. The proposed study has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Implementation of a transnational strategic management information system' under Fourth Framework.

assistant: **Concept**

The project (MIDAS) is about development and pilot implementation of a extended strategic management information system for a transnational European manufacturing. The system will also open the way for common and transnational customer/supplier links using EDI. Our company has separate operating businesses in five European countries. A central company objective is to enable these businesses to function as a single European company in a single European market, developing integrated transnational systems to consolidate the benefits of a single market, systems that take into account the uniquie diversity and complexity of culture, language and established business practice across Europe's frontiers.The model will allow a transnational customer to be given a single European bill of goods ordered and supplied from various plants in various countries and the reverse for suppliers. It will enable management to monitor a complex production and stocking operation across borders, significantly improving efficiency, reducing waste and saving energy.MIDAS has three objectives:- To unify a series of independent businesses located in several European countries by introducing common software in an integrated programme designed to embrace all major management functions, enabling CPE to trade as a single company in the Single Market.- To provide the opportunity to view all major functions of the business, e.g. production performance, material usage, stock levels, finance, etc., in 'real time' even though the business is operating on a transnational basis.- To lay the basis of a system of a Electronic Data Interchange, whereby orders, invoices and payments, in particular, can be made electronically in common format across national borders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Standardization of flow cytometrie assays for clinical cell analysis' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Flow cytometric cell analysis has evolved as an important diagnostic tool in the clinical laboratory. Diagnostic applications include:1) the enumeration ofIymphocyte subsets and assessment of their activation status and function in immunodeficiency (AIDS, transplantation) and autoimmunity;2) immunological characterization of hematological malignancies for classification and monitoring of residual disease;3) platelet activation as a prognostic marker in cardiovascular disease and analysis of platelet function in coagulation disorders; and4) enumeration of hematopoietic progenitor cells for timing, dosing and quality control of stem cell transplants for cancer treatment. The increasing sophistication of flow cytometric techniques has greatly advanced the sensitivity and specificity of the above assays. At the same time, their application by an ever-widening range of laboratories calls for technology standardization, establishment of common assay protocols and the implementationof external quality assessment schemes.The European Working Group on Clinical Cell Analysis brings together, through this Reinforced Concertation programme, 16 groups in 13 European countries engaged in flow cytometric diagnostic applications and the industrial partners supplying the technology for these fields. The united expertise of these groupscovers the main technological areas needed for most flow cytometric diagnostic applications. The first goal of the programme is to optimize the required technologies and to reach consensus on their use: a) instrument set-up and calibration; b) sample preparation for multicolor flow cytometry; c) absolute cell count assessment; d) intracellular staining; e) quantitation of antigen expression; and f) flow cytometric data analysis. This first set of deliverab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A theoretical framework for swarms of GRN-controlled agents which display adaptive tissue-like organisation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The Swarm-Organ project focuses on systems containing large numbers of autonomous but relatively simple agents, whose goal is to collectively organise themselves into complex spatial arrangements despite each agent having only local awareness. This particular question is directly relevant to both biological morphogenesis, and to new paradigms of distributed technology such as robotic swarms and amorphous computing. Two levels of adaptation are either evident or required in these systems: (1) As the whole system changes over time, individual agents find themselves in different local situations and must adapt and adjust their behavior accordingly, for example dealing with conflict resolution and/or cooperation with neighbours. (2) The swarm must also adapt to the outside world (or the world it is embedded in) in various ways depending on its task – for example, coping with damage, maintaining functionality under changing environmental conditions, or tracking objects. A fundamental challenge in this field is how to design the local control system of each agent, and the Swarm-Organ project will extensively explore a specific approach – namely the use of GRNs (gene regulatory networks) – as a potentially powerful control method for these systems. By focusing on GRNs we will develop a theoretical framework about distributed adaptive control, which will be equally informative to both natural biological morphogenesis, as well as next generation technologies in robotics and computation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Researchers for Humanity 2020' (R4H2020).

assistant: **Concept**

Continuing the series of events from 2007 organized in Romania, “Researchers for Humanity 2020” will build a strong link between public and research by stating the main message that science and researchers are useful for daily life and humanity over all, and their life is as everyone else’s. For one day (or 2 days in some places), the public will have the chance to meet important players from science and education through play, interesting talks and interactive hands-on learning. Based on the outstanding awareness of the European dimension of the event that we created throughout the years, European Researchers Night 2020 will confirm as being one of the most important communication event for research and education institutions. After last 2 years of enlarging the network (21 big, medium and small cities from all over Romania), this time we will focus on strengthening  and increasing the quality of the interactions by gathering over 400 researchers, students and teachers in order to reach 45 000 visitors and over 650 000 persons exposed to the awareness campaign. The traditional logo of the event will be maintained so that a coherent link will be created with the European and national dimension of the event. Also, through the platform, we will invite associated events to get enrolled and be supported by us through promotion at the national level. Due to the long lasting relationships, the partnerships will be continued with main actors from mass-media, private research, universities and non-formal education institutions.


**Keywords:** Science, Researchers, Science fun, Learning, R4H, Caravan,Youngsters, Research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Membrane-based phononic engineering for energy harvesting' (MERGING) under Seventh Framework.

assistant: **Objectives**

The aim of this proposal is to realise a compact thermoelectric module to harvest the energy of devices to be used in applications requiring heterogeneous integration packaging techniques leading to small size, integrability and high thermoelectric efficiency.Our concept, which goes up to a test device, is based on deep understanding of the behaviour of phonons, their control leading to the control of thermal transport. It is based on minimizing the thermal conductance and or thermal conductivity by phonon engineering. A ZT=2.5 is targeted together with module compactness and integration potential.The module will be based on technologies combining Si microelectronics, thin film thermoelectric material and novel concepts to understand heat transport in 2-dimensional (2D) nanostructured materials such as Si-based ultrathin membranes, GeMn and strontium titanate. The device will carry enough current but insignificant or little heat. Theoretical and experimental investigations of heat transport will be carried out.The methods and technologies developed will enable nm-scale control of energy generation and heat flow. This will impact on on-chip and in-package energy management that is of crucial importance for future technologies. Especially, our targets contribute to (a) on-chip harvesting of thermoelectricity and (b) management of heat flow in the applications of heterogeneous integration and nanoelectronics.