RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Activatable Fluorescent Probes as Smart Diagnostic Tools for Microendoscopy Imaging' under Seventh Framework.

assistant: **Concept**

My research proposal aims to develop smart fluorescent probes to be used as in-situ and real-time diagnostic tools by fibre-based confocal microendoscopy imaging with local administration. The probes will target relevant biomarkers in cancer and infection, and will be generated through a multidisciplinary approach that involves organic chemistry, cell biology, imaging and respiratory medicine. Activatable fluorescent probes are advantageous in that their fluorescent signal is triggered by a target protein, and hence they emit fluorescence ONLY AFTER interaction with the defined target (e.g. enzyme) or environment. This strategy leads to optimum signal-to-noise ratios with increased sensitivity over other optical imaging approaches and enables their use in small concentrations with no systemic administration, hence reducing any potential adverse effects and facilitating the translation to clinical applications. The current proposal will focus on two projects: 1) enzyme-activatable probes for imaging endoscopically-accesible cancer (initially targeted at lung cancer, but later also applicable to oesophagus and pancreas cancer), and 2) environment-sensitive fluorescent probes for the detection of fungal infection in lungs (i.e. pulmonary aspergillosis).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of Shock Wave Technology for Packed Meat' to be submitted under Seventh Framework.

assistant: **Abstract**

In recent years the consumer demand has shifted towards convenient, easy to prepare meat products. In Europe mainly multiple use cattle varieties (milk and meat production) are raised, providing a small amount of tender meat pieces applicable for steak production, only. To produce beef and pork meat with sufficient quality for preparation of convenience food like steaks usually a post-mortal ripening is applied. Due to a time requirement of 14 to 21 days, meat maturation causes significant storage and energy costs.In pilot scale tests it was shown, that hydrodynamic shock wave treatment results in an accelerated meat maturation and allows tremendous improvements of meat quality and economic situation of SME meat producers. But up to now shock wave technology is not marketable. The lack of industry ready equipment, the knowledge of the process-product interactions as well as suitable packaging material limit an industrial application of the technique so far.In an interdisciplinary cooperation of SMEs and RTD-Performers ShockMeat will bridge the gap from research to industrial implementation of the technique by- development of an innovative industry ready shock wave equipment including meat handling,- identification of key processing parameters and elaboration of process-product interactions,- development of technology adapted packaging material,- deriving cost models and demonstration activities.With an annual turnover of approx. 202 million Euro meat industry is the most important sector of European food industry. By enhancing meat maturation product quality will be improved and processing costs reduced. ShockMeat will contribute to improve the competitiveness of SME in the area of meat processing, equipment manufacturing as well as packaging material. The consumer will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Connected cars for real time smart road maintenance and increased driving safety' (Klimator-RSI).

assistant: **Concept**

Correct road maintenance is crucial for ensuring good traffic flow and to maintain safety standards for road users. Safety is one of the most important factors in road maintenance with over 26,000 lives lost on EU roads alone with another 135,000 seriously injured with the total social cost estimated at €100 bn. Adverse weather conditions are the primary source of road accidents, with risk increased by 9 times on snowy roads and 20 times on icy roads.Current conventional methods for monitoring and forecasting road conditions have several disadvantages such as; cannot present real-time road surface data for an entire region at road level or are too costly to implement of whole road networks. These disadvantages mean that winter road maintenance is still undertaken using the experience and decision making of the staff without the use of real-time data to aid decision making.To address this need, KLIMATOR presents its Road Status Information Technology, which uses unique algorithms to interpret 3 key data sources to monitor and predict road surface conditions on an entire road network with a well-designed and clear user interface. Our algorithms then process this data which can be represented on a visual map of the whole road network. RSI allows contractors to decrease 20-30% of winter road maintenance costs while increase the safety and efficiency of the roads by keeping them open and decreasing costs (-5% vehicle wear, -20% fuel usage). The data produced using this system will also be sold to OEM car manufacturers as a friction mapping service, to give drivers and autonomous cars real-time information to increase safety.Our business opportunity relies on an estimated Total Available Market, within the EU alone, of €54M for our RSI system and another €4M for our initial f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pluggable Platform for Personalised Multilingual Patent Search' (PerFedPat) under Seventh Framework.

assistant: **Objectives**

Patent search is an economically important problem, central to the R&D operations of many industries including pharmaceuticals, biotechnology, automotive and many more. Besides the economic interest, from a technological perspective, patent search reveals important challenges for the field of information access. This is because it has important differences (lengthy search sessions, demand for high recall, high value documents) despite it shares a number of important characteristics with web search.The PerFedPat proposal aims to research into a new generation of advanced patent search systems for the patent related industries and the whole spectrum of patent users by designing a new exciting framework for integrating multiple patent data sources, patent search tools and UIs. The iPerFedPat system, which will be the main result of the project, will have a pluggable architecture, providing core services and operations being able to integrate multiple patent data sources and patent related data streams, thus providing multiple patent search tools and UIs while hiding complexity from the end user. At the core of the system’s architecture lies the idea of Personalised Federated Search. In iPerFedPat federated search is used as a method for retrieving information from distributed data sets into user’s workbench, possibly operate and/or integrate, and finally deliver to the patent users for using them in a parallel, coordinated way. As a result the iPerFedPat system will be able to provide a rich, personalised information seeking experience for different types of patent search types, potentially exploiting techniques from diverse areas such as distributed information retrieval, machine learning  and human-computer interaction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Safe Hydrogen Injection Modelling and Management for European gas network Resilience' (SHIMMER), addressing dissemination and exploitation.

assistant: **Impact**

To accelerate the transition to a low-carbon economy while exploiting existing infrastructure, hydrogen can be injected to the natural gas network. However, the there are many technical and regulatory gaps that should be closed and adaptations and investments to be made to assure that multi-gas networks across Europe will be able to operate in a reliable and safe way while providing a highly controllable gas quality and required energy demand. Recently, the European Committee for Standardization concluded the impossibility of setting a common limiting value for hydrogen into the European gas infrastructure  recommending a case-by-case analysis. In addition to this, there are still uncertainties related to material integrity on pipelines and networks components with regards to a reduced lifetime in presence of hydrogen. Existent results from previous and ongoing projects on the hydrogen readiness of grid components should be summarized in a systematic manner together with the assessment of the existent T&D infrastructure components at European level to provide stakeholders with decision support and risk reduction information to drive future investments and the development of regulations and standards. The SHIMMER project aims to enable a higher integration and safer hydrogen injection management in multi-gas networks by contributing to the knowledge and better understanding of hydrogen projects, their risks, and opportunities. - To map and address European gas T&D infrastructure in relation to materials, components, technology, and their readiness for hydrogen blends- To define methods, tools and technologies for multi-gas network management and quality tracking, including simulation, prediction, and safe management of transients, in view of widespread hydrogen injection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Timing of the earth's core formation and differentation through the study of 182 w, 186 os and 187 os isotopes in mantle plume derived lavas.' to be submitted under Fifth Framework.

assistant: **Abstract**

The timing of Earth's core formation and inner core crystallization are among the most fundamental questions in Earth science. We propose to address these two key issues in core evolution as physical models differ greatly in their predictions. As was the case in determining the age of the Earth, isotope chronometry is required to resolve these pivotal debates. The rapid development of mass spectrometry has made accessible the appropriate Hf-W, Pt-Os and Re-Os systems to study core processes. We shall overcome the problem of applying these novel tools to material as inaccessible as the core by analyzing mantle derived material that is believed to have interacted with the core. The estimated degree of interaction is sufficient to resolve the W-isotope anomalies that would result if the core formed early and so this provides the most direct approach to this longstanding question. The lack of a W-isotope anomaly would strengthen a recent proposal that core formation was late. Second, the onset of inner core crystallization will be addressed by combining W- and Os-isotopes. The Os composition of the outer core is dependent on the timing of inner core crystallization, whereas correlated W-isotopes will indicate that the Os-signature reflects core differentiation. If Os-anomalies are present in Archean (>25 Ga) rocks, then this is evidence for even earlier onset of inner core crystallization. Published data already hints to this conclusion although it needs to be confirmed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Industrial production of high performance ecological polymeric composites based on residual / renewable cellulose fibres and post consumer thermoplastics, ecosites""'.

assistant: **Concept**

The project intends to develop at pilot plant scale technical grade composites using as raw materials waste cellulose fibers and post-consumer thermoplastics, with not less than 40% w/w of fiber and target properties Stress=60 MPa, E modulus=5 GPa and strain at failure 4%. To validate the results obtained, the composites developed will be used to manufacture a car dashboard, that will be tested for fulfillment of standards. In order to achieve these properties, a great effort will be placed in the compatibilisation of the cellulose and polymeric structures at their interphase by innovative methods. The materials developed will be analyzed at the end of the project regarding their environmental value and industrial feasibility. The proponent consortium is composed of six industries, two universities and one research organization from five different countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INSPECTO: A disruptive portable device with an innovative Method for Pesticides and contaminants Detection in Food' in the context of a Horizon 2020 call.

assistant: **Objectives**

More than 97% of European food products contain pesticide residues, according to analyses carried out by the EU’s national authorities; in fact, annual compilations showed that of the 84,341 samples of produce from conventional agriculture analysed, 97.2% contained traces of one or more of 774 pesticides.In 2016, the America’s food industry had a $55.5 billion safety problem according to Fortune magazine, because of produce recalls and money spent on food testing. In addition, consumer demand for healthy, clean produce drives the food industry to invest more in food safety to brand their product as healthy. Current methods for detecting contaminants in food do not meet the industry’s requirements.  They are too slow, stationary, complex to operate and expensive. The industries need and  a global policy for reducing pesticide use are a huge opportunity for INSPECTO’S development.Unlike existing solutions such as mass-spectrometers and lab services that offer slow, limited and expensive services, INSPECTO offers an innovative method for the detection of pesticides and contaminants in food. Our unique developments are in the field of spectroscopy allowing quick, simple and affordable detection of contaminants in food (United States Provisional Patent Application No. 62/436,571). The POC was developed in conjunction with input from food industry professionals, to be used by regulators, growers, handlers, producers, retailers and 3rd party systems such as Blockchain.OUR BUSINESS MODEL: INSPECTO offers three services; (1) sale/lease of the Inspecto’s device & licensing, (2) refill ofInspecto’s disposable cartridges, and (3) subscription to Inspecto’s data analysis.Our main objective is to make INSPECTO the global reference technology enabler to reveal pesticides in food, help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'From co-ordination models to applications' (COORDINA) under Fourth Framework.

assistant: **Objectives**

To attain its goals, the group will perform the following activities:- Foundational work. Various languages and models for co-ordination are being developed in the group.These individual efforts will be enhanced by a broad collaboration within the group, through the means of electronic communication (continuously), short visits among partners (one per partner per year, on average) and internal workshops gathering all partners (one per year).- Case studies. The assessment of the practical applicability of said languages and models is quite important, so we will set up case studies provided by the industrial partners, based on real large-scale applications and covering a wide spectrum of practical issues. All partners will work on some of these, trying to provide software solutions that will inevitably uncover merits and deficiencies of the various technical approaches.- Dissemination of results. For increasing the downstream effects of our research we plan two major dissemination activities: sponsoring a regular international conference on co-ordination, and publishing on the World Wide Web an up-to-date survey of the field that will highlight and put in context our results.Exploitation and impactWe foresee a medium-term impact of co-ordination technology on the software development process for large-scale concurrent and distributed systems, such as those for traffic management (air, railway or motorway), on-board control (in aircrafts, trains, or automobiles), process control (e.g. in chemical industries), command-and control, water level management, or energy production and distribution.For this to happen we must reach a stage of sufficient maturity and awareness of co-ordination technology, that will trigger projects in concrete application areas for its deployment.Ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Methadone Maintenance the Health Care for Drug Users: Identifying Best Praxis (Mehib)' (Mehib), addressing dissemination and exploitation.

assistant: **Impact**

MEHIB will examine the integration of methadone maintenance treatment (MMT) with other health promotion, health care and psychosocial services for opiate users. The study will focus on six cities in three EU countries that have either been historical leaders in the reduction of drug-related harm (UK) or have recently witnessed a massive expansion of MMT services (Germany and Spain) Modes of MMT provision largely across the chosen fieldwork sites. MEHIB shall conduct extensive qualitative fieldwork with users and staff meters of MMT and other health and social services for opiate users. The project will result in policy guidelines aiming to promote the broad implementation of good practice across Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reprogramming cancer cells in dendritic cells to expand tumor-reactive infiltrating lymphocytes.' in the context of a Horizon Europe call.

assistant: **Objectives**

Cancer affects 2.6 million people each year in the European Union, making it the second leading cause of death. Immunotherapies have revolutionized the treatment of cancer, seeking to re-arm immune cells against tumors. However, current immunotherapies are mostly inefficient in low immunogenic and solid tumors, which account for more than 80% of cancers in adults. A promising approach is to collect tumor infiltrating lymphocytes (TILs) from patient’s resected tumor tissue, and expand their function in vitro before reinjecting them to achieve antitumor immunity. This therapy is currently involved in many clinical trials and received a first FDA approval in 2024 for advanced melanoma treatment. Yet, a major challenge remains to amplify the diversity of tumor reactive TILs rather than the non-specific TILs. The aim of the ExpandTILs project is to selectively amplify tumor-reactive TILs to enable personalized, targeted and effective tumor killing. I will use the unique system designed by the host team, reprogramming the patient tumor cells into antigen presenting dendritic cells, to amplify tumor reactive TILs. I will establish an optimized coculture protocol with reprogrammed cancer cells to expand antigen-specific TILs, then train in cutting-edge techniques to characterize and compare their antitumor efficacy to standard-of-care TILs. This interdisciplinary approach, combining cellular reprogramming with cancer immunology, will increase our knowledge about tumor-specific TILs responses and allow us to obtain the proof-of-concept for a tumor reactive TILs expansion platform. This should lead to the creation of a new company, allowing me to learn how to bring new technologies to clinic. Therefore, this fellowship will significantly contribute to my professional growth by al