RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bayesian inference of massive black hole binaries formation and evolution scenarios with gravitational waves' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The massive black holes (MBHs) that we currently observe in the center of galaxies are the final stage of a complex evolutionary path in which seed BHs at high redshift grow in proto-galaxies through episodes of merger and accretion.If MBHs are brought sufficiently close during a galaxy collision, they can merge, emitting gravitational waves (GWs). In 2034, the Laser Interferometer Space Antenna (LISA) will observe the GWs from merging MBHBs across the entire Universe, providing exquisite estimates of the binary parameters. As astrophysical processes, such as gas accretion, supernova feedback and dynamics, leave an imprint on the MBHBs masses, merging redshift, spins and eccentricity distributions, detecting MBHBs will provide us indirectly information on MBHBs formation and evolution scenarios.The scope of the project is to asses LISA ability to constrain the MBHBs astrophysical and formation mechanisms, combining state-of-the-art simulations to predict the MBHBs population with reverse Gaussian process and hierarchical Bayesian analysis.We plan to implement a semi-analytic model (SAM) to describe the complex processes shaping the MBHBs distribution and to model astrophysical processes and formation scenarios with population hyperparameters. We will construct a grid in the hyperparameter space where each node will correspond to a realistic population of MBHBs. These points will serve as a template bank for a Gaussian Process interpolator, which in turn will be the backbone of a hierarchical Bayesian inference framework. This framework will be employed to extract the posterior distributions of the population hyperparameters with the final goal of inferring the contribution of different astrophysical processes to the MBHBs population.


**Keywords:** Black hole binaries
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Early market introduction of new energy technologies by the opet network in liaison with science and technology', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Many of the currently operating OPETs are focusing on the promotion of established technologies in differing contexts, however, with only meagre reflection of science and research. An immediate interpretation is that there seems to be a missing link in the OPET Network: there is no activity dedicated to opportunities of science and research in the field of enabling energy-and-environmental technologies. The proposed EMINENT network will provide a link between early stage technologies, achieved by R&D organisations on the one hand, and the OPET network on the other. By evaluating the Early Stage Technologies (EST^TMs) on their potential fields of application before offering them to the OPET network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Mapping the 3-dimensional gluon structure of the proton'.

assistant: **Concept**

Gluons, together with quarks, are the fundamental constituents of the proton. They generate almost all its mass, carry about half of its momentum and contribute to its spin in a still unconstrained amount. Mapping their three-dimensional (3D) structure in the proton is crucial in our understanding of Quantum Chromodynamics and matter in general. The quark and gluon 3D content in momentum space is encoded in the so-called Transverse-Momentum-Dependent distribution/fragmentation functions (TMDs). While a huge progress has been made recently in the quark sector, the gluon sector is much less developed, due to the difficulty to cleanly probe gluons in high-energy processes. A very promising and also challenging way to access them is through quarkonium production. However, we still lack a solid framework which connects gluon TMDs to these processes.GlueCore will provide this new theoretical framework to properly access (un)polarized gluon TMDs through quarkonium production, also in view of the construction of new experimental facilities in Europe and the United States, with the goal of collecting a wealth of data useful for gluon mapping. GlueCore will also test the newly derived framework by performing the first phenomenological extraction of gluon TMDs, through the application of cutting-edge fitting techniques. This project will contribute to the EU H2020 priority “Excellent Science”, bringing new insights into our quest of understanding the fundamental structure of matter. It will result in several high-impact peer-reviewed articles, conference presentations and opportunities to more broadly disseminate the findings. Moreover, undertaking this research at the INFN- Pavia Division, one of the world leaders in the study of hadron structure and QCD, along with formal traini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Roles of miRNAs in Herpes simplex virus 1 infection' (HSVMIR-IJ) targeting Seventh Framework.

assistant: **Abstract**

Herpes simplex virus 1 (HSV-1) is important human pathogen widely known as the causative agent of cold sores, and it is the leading infectious cause of blindness, and the most common cause of sporadic encephalitis. Although intensively studied, many fundamental aspects of the HSV-1 biology are poorly understood, including the control of latency and regulation of gene expression. We have recently discovered numerous miRNAs, a class of small regulatory non-coding RNAs, expressed by HSV-1 and closely related virus, HSV-2, revealing a new paradigm for the HSV gene regulation. Some of these miRNAs are conserved between these two viruses and expressed differentially during different phases of infection; however function of most HSV miRNAs is unknown. We hypothesize that miRNAs have a central role in modulating the host-pathogen interaction that leads to efficient virus replication and establishment of latency. Also, we hypothesize that miRNA have a central role in establishing the threshold for the reactivation upon different stimuli, i.e. control of the lytic-latent switch. Here we seek to understand the roles of microRNAs (miRNAs), encoded by the virus and host, in the regulation of gene expression during lytic and latent HSV-1 infection. We primarily focus on functions of miR-H1 and miR-H6, HSV-1 miRNAs abundantly expressed during lytic infection, and lytic and latent infection, respectively, and miRNAs almost entirely complementary to each other. In our preliminary data, we have generated the HSV-1 mutant impaired for the expression of these miRNAs and characterize the mutant in vitro and in a mouse model. In addition, to enable high-throughput technologies, we have tested several in vitro latency models and characterized the expression of HSV-1 and host miRNAs in these m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'COMPASS: Climate-relevant Ocean Measurements and Processes on the Antarctic continental Shelf and Slope' (COMPASS), addressing dissemination and exploitation.

assistant: **Impact**

Processes on the Antarctic continental shelf and slope are crucially important for determining the rate of future sea level rise, setting the properties and volume of dense bottom water exported globally, and regulating the carbon cycle. Yet our ability to model and predict these processes over future decades remains rudimentary. This deficiency in understanding originates in a lack of observations in this inaccessible region. The COMPASS project seeks to rectify that by exploiting new technology - autonomous marine vehicles called gliders - to observe, quantify and elucidate processes on the continental shelf and slope of Antarctica that are important for climate.The COMPASS objective is to make a step-change in our quantitative understanding of: (i) the ocean front that marks the boundary between the Antarctic continental shelf and the open ocean, and its associated current system; (ii) the interaction between ocean, atmosphere and sea-ice on the Antarctic continental shelf; and (iii) the exchange of heat, salt and freshwater with the cavities beneath ice shelves. These goals will be met by a series of targeted ocean glider campaigns around Antarctica, spanning different flow regimes, including areas where warm water is able to access the continental shelf and influence ice shelves, areas where the continental shelf is cold and fresh, and areas where the continental shelf hosts cold, salty, dense water that eventually spills into the abyss. A unique circumpolar assessment of ocean properties and dynamics, including instabilities and mixing, will be undertaken. COMPASS will develop new technology to deploy a profiling glider into inaccessible environments such as Antarctic polynyas (regions of open water surrounded by sea-ice). As well as scientific breakthroughs that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and validation of immunoanalytical methods for the determination of plant protection products and related compounds' in the context of a Fourth Framework call.

assistant: **Objectives**

Foreseen ResultsOur project is devided in five different Tasks :Task 1 Hapten synthesisTask 2 Hapten conjugation to proteins (preparation of immunogen), hapten conjugation to fluorescent dye molecules.Task 3 Immunization.Task 4 Antibody characterization and optimization of assay conditions .Task 5 Assay validation.For each compound we will follow these five Tasks.We will look for industrial exploitation in case of successful development of the assay.Many hundreds of pesticides are widely used in Europe. This may pose problems for possible contamination of waters, food and other matrices.At present they are mostly determined in laboratory by instrumental methods involving liquid or gas chromatography. These techniques are, however, time consuming, expensive, and require skilled personnel.Immunoanalytical methods for the detection of small molecules have recently gained importance in environmental monitoring. Immunochemistry promises to dramatically reduce the cost of residue analysis of certain toxic substances in the environment while retaining the requisite sensitivity, precision and accuracy.In this research proposal we suggest to develop enzyme-linked immunoassay (ELISA) and polarization fluoroimmunoassay (PFIA) systems for the detection and separation of candidate pesticidal compounds. In parallel to these assays and in order to confirm the above immunoanalytical systems, HPLC and GC-MS validation experiments are also planned. Interlaboratory analysis will be done, comparing performances (such as LOD, linearity, range, etc.) and results with different techniques.The present proposal focuses on selected pesticides chosen on the basis of these criteria:- They are widely used particulary in CEC/NIS countries, but also in EU countries.- They are difficult to detect or m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multi-site concurrent engineering for large aircraft engineering & support' (MUSCLES) under Fourth Framework.

assistant: **Objectives**

Rationale : The European Aerospace Industry can only survive in the increasingly competitive environment through cost effective collaboration and by proposing its products at the lower acquisition and in service costs. Airbus partners and subcontractors have been used for years to develop jointly and successfully transport aircraft. However, to win the Large Aircraft competition Airbus partners have engaged a drastic change of their development process towards Concurrent Engineering (CE), which is the key issue as identified by the AIT-Pilot Phase (ESPRIT 7704) to reduce development costs and times.Current practice demonstrates, that about 40% of the overall development costs of Large Aircraft are based on collaboration overhead, harmonisation and information exchange, which are in fact non-value adding processes.Need for action : Only if non-value added costs are reduced significantly with a parallel shortening of development times the Airbus partners can stay competitive, maintain and enhance its market share on the global market place of Large Aircrafts. Implementing C.E. in such a European and industrial scale (4 main partners, thousands of suppliers and subcontractors) for such a complex product is an immense challenge. Existing works in C.E. do not address this critical size and complexity.Objectives : The objective of MUSCLES is to provide a methodology to redesign the development process within the Airbus partners, implementing integration of human resource management, process engineering & management issues and ICT enablers according C.E. principles and using distributed Digital Mock-Up techniques. It will be one of the corner stone of A3XX success.Delivering the basic skeleton and tools for complex multi-site Concurrent Engineering, MUSCLES intends mainly to c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Oxygen Optimization  Therapy through BCPAP for management of childhood pneumonia in general hospitals of LMICs' (OPT-bCPAP) under Horizon Europe.

assistant: **Objectives**

Pneumonia is a leading cause of morbidity and mortality especially among children in sub-Saharan Africa. Nigeria and Ethiopia are among the 5 countries that account for half of the under-five pneumonia deaths. Majority of the deaths from pneumonia are however preventable with early diagnosis and appropriate management. In children with pneumonia, hypoxemia is quite common and constitutes a major risk factor for death. The WHO and other leading child health agencies urge widespread access to oxygen therapy. Bubble continuous positive airway pressure (bCPAP) is a method of delivering oxygen and positive pressure into the airways thus keeping the alveoli open for improved gas exchange. While use of bCPAP devices appears safe and effective worldwide, scaling of quality bCPAP devices in low- and middle-income countries (LMICs) has been limited. This has prevented most children in LMICs from receiving life-saving non-invasive respiratory support which could have saved many lives. Achieving Sustainable Development Goal (SDG) 3.2 of the reduction of under-5 mortality to at least as low as 25 per 1,000 live births by 2030 will likely not be possible without access to innovative and low cost interventions devices such as bCPAP in LMICs. The aim of the OPT-bCPAP is to perform context-appropriate scale-up of bCPAP in settings of very high disease burden (Nigeria, Ethiopia and Malawi) using the the positive results and the lessons learned from clinical trials conducted in Ethiopia, Bangladesh and Ghana. In addition to scaling up bCPAP, we will deeply explore additional factors associated with treatment failure and mortality from severe pneumonia, we aim to generate data on adherence to treatment guidelines, healthcare-seeking behaviour, magnitude of respiratory syncytial virus infec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neurophysiological Biomarkers of Cortical Plasticity Induced by Neuromodulation' (NeuroN) targeting Horizon 2020.

assistant: **Abstract**

One of the major issues when dealing with therapies for the rehabilitation of the lower limbs in stroke survivors is the in-deep assessment of their effectiveness and the lack of biomarkers for motor recovery. The motor functionality after therapy is evaluated only through clinical tests and scales which do not give information on the effective muscle state and the changes at the corticospinal level. The aim of restoring the motor functions has moved much of the attention of clinicians and researcher towards the use of the combination of brain stimulation techniques for the assessment of cortical excitability and Brain-Computer Interfaces (BCI) for the control of rehabilitation devices. This intervention induces cortical plasticity and reactivates the closed-loop pathway between the impaired cortical tract and the limb by using the cortical command to drive the device for the generation of the afferent volley. However, nothing is known about the changes of the neurophysiological correlates and how these influence the effective recovery of motor functions. NeuroN represents the first systematic attempt to investigate the neurophysiological correlates of changes in the excitability of the cortical areas responsible for ankle dorsiflexion in chronic hemiparetic stroke survivors with drop foot impairment and to identify novel biomarkers of motor recovery. NeuroN aims at filling the gap of knowledge on the functional effects of increased plasticity in chronic stroke survivors by integrating a BCI robot-based platform with the high-density surface electromyographic (HD-sEMG) recordings. The information coming from the decomposition of HD-sEMG signals give insight into the behavior of the motoneurons in the spinal cord and on the effective control command. NeuroN is expected t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Alveolar macrophage involvement in the pathogenesis of influenza A virus' under Seventh Framework.

assistant: **Concept**

Influenza viruses are among the most common causes of respiratory infections in humans, and are associated with high morbidity and mortality. Lung or alveolar macrophages (AM) are among the first cells to react to influenza A challenge, and their activation causes increased phagocytosis and production of numerous proinflammatory cytokines. Targeting of the AM by incoming influenza virus may be important because of the macrophage role in limiting viral replication and in the immune response to viral infection. We propose to determine the role of AM in the early response and the pathology of influenza. We conjecture that (i) infection of AM by influenza is among the first steps of viral establishment in the lung alveolae and is a determining event in the course of productive infection; (ii) AM are responsible for the major debilitating effects of highly pathogenic influenza infection through exacerbated cytokine expression; and (iii) improved understanding and prevention of AM infection should provide means to reduce the lethality of influenza human infections and contribute to influenza pandemic preparedness plans. Our specific aims are: (i) to determine the role of AM as a host for influenza during the early steps of lung infection; (ii) to determine the response of AM to influenza infection and their role in the evolution of disease; (iii) to evaluate the impact of alveolar influenza infection on the susceptibility to bacterial co-infection and to investigate the underlying mechanisms ; and (iv) to define ways in which AM can be protected from influenza infection and limit systemic damage caused by the massive cytokine response. Experiments will be performed in vitro using human blood macrophages and in vivo using AM from lungs of infected mice or cotton rats, Effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SPACE-BASED APPLICATIONS FOR TRANSPORT MONITORING AND MANAGEMENT' (SPATRA).

assistant: **Innovation**

SPATRA aims at increasing the use of satellite data in land transport by developing two demonstrators in new downstream applications for monitoring and management of rail and road transport. SPATRA will use satellite with assisted in-situ data to develop two innovative applications for smart transport and logistics, to solve problems of principal modes of land transport, road and rail: road traffic congestions and negative impact of extreme temperatures on railway infrastructure. •SPATRA will provide benefits of satellite-based logistics and road traffic flow monitoring extended beyond improved efficiency by reducing congestion and improving the flow of goods and people. •A novel space-based service predicting the risk of rail buckling based on downstream application for estimation of the rail temperature will be developed that can support rail management plan to prevent track buckling induced train derailments.


**Keywords:** Road Transport, Rail Transport