RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissecting the role of the epigenetic regulator TET2 in colorectal cancer' (TETCOLON) under Horizon 2020.

assistant: **Objectives**

Colorectal cancer (CRC) results from the accumulation of genetic and epigenetic changes in colonic epithelial cells. Epigenome studies revealed that virtually all CRCs contain aberrantly methylated genes and perturbed methylation patterns. Ten-Eleven Translocation (TET) protein family dioxygenases oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further to other oxidized 5mCs, supporting active DNA demethylation and helping maintain epigenomic stability. Loss of TET1 is an oncogenic driver in some CRCs. My preliminary analysis indicates that human CRCs have low TET2 mRNA levels compared to normal colorectal tissue, and suggests that low TET2 expression predicts increased mutational load and reduced overall survival. However, whether TET2 deficiency contributes to CRC pathogenesis, or represents a bystander event, remains to be established.In this proposal, I will elucidate the role of TET2 in CRC pathogenesis by testing whether TET2 knockdown induces methylome and transcriptome reprogramming, ultimately promoting (epi)genomic instability and tumor growth. I will also investigate correlations between TET2 defects and molecular/clinico-pathological parameters, and probe TET2 expression as predictive biomarker of response to CRC therapies. With these aims, I will use a multi-disciplinary approach, combining cell biology, cancer epigenetics, bioinformatics, human and mouse studies with cutting-edge techniques such as 3D cell culture and RNA-seq. This study should establish a clear causal link between TET2 loss and CRC pathogenesis, providing new insight into the mechanism of TET2-mediated tumor suppression and leading to the development of innovative therapies that exploit vulnerabilities of TET2-deficient CRC cells. Overall, this project has both basic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improved methodological and technical approach to external hazards safety issues in the aerospace industry' (EXT-HAZ), addressing dissemination and exploitation.

assistant: **Impact**

The industry would benefit from improvements related to external hazards working methods and scientific knowledge: understanding the different phenomena, possessing the adequate models, mastering the optimisation of protection measures, integrating the external hazards protection measures to the overall product development and exploitation cycle... all these are fields where improvements are possible and necessary to remain competitive, cut design, manufacturing and exploitation costs while ensuring or improving safety.The work planned in this thematic network covers three aspects of these issues: * Optimise sharing and enhancement of knowledge through the increased effectiveness of those projects sharing common roots and goals. * Analyze working methods, interactions between specifications / design / certification / production / exploitation and regulations. It is also possible to analyse methods used in each of those fields, such as methods employed to reach certification. * Analyze scientific and technical commonality, links and overlaps between external hazards issues and projects. From both a methodologic and scientific point of view it would be interesting in particular to look at the two following topics: * Analyzing gap between scientific state of art and current regulations. *Comparing protection vs detection vs prediction strategies. In pursuing these goals scientific and technical exchanges between specialists of different institutes and companies will be enhanced: The creation of the EXT-HAZ thematic network will bring together people working on the four areas mentioned above. These people can be divided into two categories: - aircraft manufacturers, with needs in improving the safety of their products or reducing the costs by using optimised protection. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ECL-based Infectious Pathogen (bio)SEnsor' to be submitted under Horizon Europe.

assistant: **Abstract**

Infectious diseases are a threat to mankind since their appearance in human history. Despite the advances in science and technologies, such threats are still recurrent, as recently shown by the COVID-19 pandemic in 2020 – 2021, which has revealed the urgent need for novel tools for pathogen detection that would be at the same time reliable, fast, cheap, portable and simple. The goal of ECLIPSE is to address this need, with a new platform exploiting innovative ultrasensitive protocols for the detection of pathogens. ECLIPSE builds on the combination of interdisciplinary elements to facilitate the transfer to industry, i.e., (i) ElectroChemiLuminescence (ECL) as a very sensitive transduction mechanism for realizing simple, portable and cheap devices, (ii) bio-, nano-, and supramolecular-based signal amplification structures for increasing the sensitivity, and (iii) two recognition strategies to afford high affinity and selectivity, thus leading to high reliability: the Phage-Sandwich technology for the whole pathogen, and the Surface Cooperative Hybridization technology for microbial and viral nucleic acid. We will demonstrate the feasibility and adaptability of the ECLIPSE platform with three test cases: a virus (SARS-CoV-2), a bacterium (Pseudomonas aeruginosa) and a protozoan parasite (Leishmania infantum). The platform is designed to be applied to many other infectious agents, making it a ""ready for the next pandemic” technology. ECLIPSE is expected to become a game-changer in European countries, where it could be a cornerstone for fast testing and reliable tracking of infections, and in developing countries that will benefit from a cheap and simple approach to detect the many infectious diseases that affect millions of people every year. The project results will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'E-Mobility Life Cycle Assessment Recommendations', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The eLCAr (E-Mobility Life Cycle Assessment Recommendations) project aims at supporting the process of assessing the environmental impact of electric vehicles. In order to do so a set of guidelines derived from the ILCD Handbook and adapted to the specific requirements of the projects of the Green Cars PPP is designed. This set of guidelines will be benchmarked according to a set of criteria such as applicability, practicability and ease of use and disseminated in an up to date fashion relying on interactive and online training materials.The guidelines will answer questions of how to treat ambiguities in the analysis of all aspects of electric mobility. They also provide a coherent benchmark framework enabling an ecological comparison of electric vehicles with other technological such as bio-fuel propelled cars and hydrogen based mobility. The project work plan reflects the broad range of topics such as battery and electric component production, typical vehicle utilization and driving cycles, interaction between electricity storage, power generation and grid services, as well as end of life and recycling by covering the different stages of an EV’s life.Stakeholders will be actively involved in the process, either by taking part in a number of input workshops or by participating in the project’s advisory board, which will ensure the crucial feedback from practitioners in the industry. Special attention will be paid to the requirements of participants of the Green Car Initiative, of which some stakeholders have already declared their support for and willingness to assist the project.Furthermore, the eLCAr project will develop training materials and concepts which will facilitate a swift and sustainable diffusion of the results into the respective stakeholder groups. Thus
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Enhanced micropollutant oxidation by permanganate- and manganese(II)-based processes in presence of dissolved organic matter and hydrogen peroxide'.

assistant: **Objectives**

Micropollutants are a serious problem for drinking water and wastewater due to their adverse human and ecosystem’s health effects. In Europe, their abatement often involves ozonation with O3 and hydroxyl radical abating a wide spectrum of micropollutants. However, the potential formation of carcinogenic disinfection byproducts such as bromate and N-nitrosamines threatens the safety of drinking water/wastewater. Permanganate (Mn(VII)) is a selective oxidant that is widely applied in pre-oxidation steps in water treatment to remove Mn(II), Fe(II) and taste/odor and produces little disinfection byproducts. It has a high reactivity with phenolic compounds. The applicant found that the phenolic moieties in dissolved organic matter (DOM) produce secondary oxidants with permanganate to enhance micropollutant abatement. Furthermore, the applicant discovered that hydrogen peroxide (H2O2) can not only produce secondary oxidants including Mn(VI) and superoxide radical when reacting with permanganate to enhance micropollutant abatement, but also reduce permanganate to MnO2 that can be removed during coagulation and filtration. Moreover, superoxide and hydroxyl radical were observed to be produced by the Mn(II)-H2O2 reaction. As another matrix, bicarbonate (HCO3–/CO32–) facilitated the Mn(II)-H2O2 reaction to achieve a fast micropollutant abatement, which shows a good application potential for reduced water sources by dosing H2O2. This project aims to investigate the kinetics and mechanisms of the enhancing role of DOM, its surrogate compounds and H2O2 on MnO4–-induced micropollutant abatement. Furthermore, the effectiveness of Mn(II)/H2O2(/HCO3–/CO32–) for micropollutant abatement will be investigated. Both processes will provide alternative enhanced oxidative treatment to abate mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'COnnecting INVestment Ecosystems by Strengthening  Transparency and INclusion' (CO-INVESTIN).

assistant: **Concept**

CO-INVESTIN focuses on creating cross-border co-investment opportunities for modest and moderate EU ecosystems by leveraging promising startups in the portfolio of local investors to attract foreign investors from more advanced ecosystems in their new rounds. To achieve that, the partners will pilot the approach in 4 emerging ecosystems (EL, BG, RO, PT) where the consortium partners have a strong footprint and progressively integrate at least 10 additional emerging/ moderate ecosystems by the end of the project. The project focuses on the funding gap around the Series A, very acute in these ecosystems both from the lack of capital and investors perspective, as well as in terms of deal size with respect to more advanced ecosystems. As demonstrated by the recent experience with the EIC Fund, identifying a lead investor and co-investors is a challenging task for DeepTech start-ups, in particular the ones from emerging ecosystems.The CO-INVESTIN approach relies on 4 main dimensions, that cover in a complete manner both the analytic and the action oriented dimensions of the approach: 1. Investment gap analysis, 2. Development of Market Orientation Programmes, 3. Stimulating cross-border investments and 4. Upscaling the framework and enhancing its impacts.The main project results include:•At least 5 working groups to foster the creation of structured and coordinated networks•At least 20 peer investor match-making sessions•Establishment of local CPI and activation of the Assistance Service for foreign investors•Market orientation programmes for European investors, with emphasis on women for at least 10 ecosystems•5 networking review sessions & VC syndication to encourage joint ventures & Cooperation with innovation agencies•2 International business forums & conferences to attr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Efmc2003'.

assistant: **Concept**

The Euromech Fluid Mechanics Conference will be held in Toulouse (France) from August 24 to August 28, 2003. This conference, organised under the auspices of EUROMECH by the Institut de Mécanique des Fluides de Toulouse, will be the fifth in the series started in Cambridge in 1991 and continued in Warsaw (1994), Göttingen (1997), and Eindhoven (2000). The conference will cover the whole field of Fluid Dynamics, ranging from very fundamental aspects to recent applications. This conference will provide a unique opportunity for fluid dynamicists to see what is going on in this very active field in Europe and to exchange their views on recent developments.The conference will comprise invited lectures, oral presentations, poster sessions, and three mini-symposia dealing with selected topics. Selection of papers will be made on the basis of a one-page abstract. Following the general policy of EUROMECH Conferences, no proceedings will be published. Regular sessions will involve almost all the topics of modern Fluid Dynamics, among which Bio-fluid Mechanics, Aerodynamics, Turbulence, Particles, Drops and Bubbles, Hydrodynamic Instabilities, Flow Control, Surface and Internal Waves, Geophysical Fluid Dynamics, Low-Reynolds-Number flows and Microfluidics, Non-Newtonian Flows, Computational Fluid Mechanics, Magnetohydrodynamics, Vortex Dynamics, Foams, Granular Flows, Porous Media, Reactive Flows and Combustion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Role of the sorting receptor SorCS1 in controlling excitation/inhibition balance in neural circuits.'.

assistant: **Innovation**

Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders. The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important. The host laboratory recently identified the sorting receptor SorCS1 as a key regulator of the synaptic abundance of glutamate receptors and adhesion molecules, including neurexins and neuroligins. SorCS1 has been associated with a variety of neural disorders, including autism, schizophrenia, and Alzheimer’s disease. I hypothesize that SorCS1 controls E/I balance in the brain by regulating the synaptic abundance of cell surface receptors. I shall test this hypothesis via the following specific aims:Aim 1: To analyse whether SorCS1 regulates synaptic trafficking of adhesion molecules and neurotransmitter receptors under basal conditions and during synaptic activity.Aim 2: To define how SorCS1 affects excitatory and inhibitory synapse function in vitro and in vivo.Aim 3: To determine whether perturbed SorCS1 levels and disease-associated SorCS1 mutations affect E/I balance in neural circuits.


**Keywords:** SorCS1, excitation, inhibition balance, synaptic function, cell adhesion molecules, autism
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multi-analyte liquid biopsy to monitor tumor genomic evolution and therapy response in advanced Prostate Cancer' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Metastatic prostate cancer (mPC) is a lethal disease. Androgen deprivation therapy is the mainstay of patient care. In addition, DNA repair defects is a novel therapeutic target in mPC. However, resistances invariably arise, triggered most of the times by tumor genomic evolution. Liquid biopsy has emerged as a tool to non-invasively profile tumor genomics over time. Beyond circulating tumor DNA (ctDNA) and circulating tumor cells (CTC), small extracellular vesicles, known as exosomes, have been identified to contain tumor genomic material. Over the last years, I have developed a method to pursue analysis of tumor genomic material from exosomes at a very low cost. The analysis of exoDNA/RNA is a promising tool that represents a new non-invasive, sensitive and very informative new method for PC monitoring. In this project, I aim to integrate the genomic analysis of exoDNA/RNA together with ctDNA and CTCs in advanced PC to:1) Identify prognostic signatures for clinically-relevant patient stratification; 2) Define circulating predictive signatures of drug response/resistance; and 3) Validate biomarkers of therapy response for selection of subsequent lines of treatment.Therefore, this fellowship would allow me to take a significant step towards the implementation of this new technology in the study of mPC genomics and mechanisms of response/resistance to novel targeted drugs. Furthermore, I will be able to integrate my research into clinical trials and, ultimately, impact personalized patient care.


**Keywords:** Prostate Cancer, Liquid Biopsy, Personalized Medicine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Nanotechnology Computer Aided Design' in the context of a Fifth Framework call.

assistant: **Objectives**

The development of novel devices at the nanometer scale with potential for large-scale integration and room temperature operation is a challenging task. The quest for nanotechnology information devices will greatly benefit from a more intensive use of tools for detailed modelling of molecular and nanoelectronic devices. Nanotcad is an integrated theoretical and experimental project aimed at1) developing and validating a software package for the simulation and the design of a wide spectrum of nanoscale devices, based both on semiconductors and on transport through single molecules. The NANOTCAD package will be made freely available to the Nanotechnology Information Device community.2) The fabrication and optimisation of semiconductor and molecular nanodevices on the basis of the modelling tools developed.The development of novel devices at the nanometer scale with potential for large-scale integration and room temperature operation is a challenging task. The quest for nanotechnology information devices will greatly benefit from a more intensive use of tools for detailed modelling of molecular and nanoelectronic devices. Nanotcad is an integrated theoretical and experimental project aimed at1) developing and validating a software package for the simulation and the design of a wide spectrum of nanoscale devices, based both on semiconductors and on transport through single molecules. The NANOTCAD package will be made freely available to the Nanotechnology Information Device community.2) The fabrication and optimisation of semiconductor and molecular nanodevices on the basis of the modelling tools developed.OBJECTIVESThe NANOTCAD project has four main objectives:1. The development and the validation of a software package for the simulation and the design of a wide spectrum o