RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Prevention of Obesity-Related Inflammation' in the context of a Seventh Framework call.

assistant: **Objectives**

According to the World Health Organization (WHO), 1.6 billion adults are overweight and 300 million people are obese worldwide. One of the major consequences of these high rates is manifested by the increased prevalence of Type II Diabetes Mellitus (T2D). The search for novel therapies requires a better understanding of the T2D pathophysiology. In this regard, there is still a considerable lack of knowledge concerning the immunopathogenesis of T2D. We discovered a natural phytohormone -- abscisic acid (ABA) -- with significant glucose normalizing and immunomodulatory properties, which may prove instrumental in exploring the links between immunity and T2D. Our preliminary data suggest that ABA ameliorates glucose tolerance and white adipose tissue (WAT) inflammation by acting on peroxisome proliferator-activated receptor γ (PPAR γ). Our long-term goal is to characterize the mechanisms by which ABA ameliorates obesity-related inflammation. Specific aim 1 will test the hypothesis that ABA down-modulates monocyte chemoattractant protein-1 (MCP-1) production through a PPAR γ-mediated blockade of nuclear factor-κB (NF-κB). More specifically, we will dissect the mechanisms of transcriptional regulation of MCP-1 expression by ABA by: 1) Determining the influence of ABA treatment on the DNA-binding activity of NF-κB in macrophages; 2) Investigating whether ABA represses the expression of NF-κB subunits or induces IκBα expression under inflammatory conditions, 3) Assessing the physical interaction of ABA-activated PPAR γ and RelA and its role in inhibiting MCP-1 expression in macrophages; and 4) Determining if ABA suppresses obesity-induced MCP-1 expression by activating PPAR γ and inhibiting NF-κB. Specific Aim 2 will evaluate the differential ability of ABA’s enantiomers and is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PJ01 Wave 2 Enhanced Arrivals and Departures' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In order to meet the forecast traffic growth, and in particular to address the performance issues encountered in summer 2018, PJ01-W2 will develop concepts, tools and procedures to increase the capacity of Terminal Manoeuvring Areas (TMAs) in a safe, cost-effective and environmentally sustainable manner. This will be achieved by taking advantage of the latest technological developments from both an airborne and a ground-system perspective and through the secure sharing of data. The needs of all Airspace Users will be addressed including Rotorcraft.The aim will be to improve the capacity whilst exploiting the environmental benefits achieved from Continuous Climb Operations (CCO), Continuous Descent Operations (CDO) and improved arrival sequencing. A focus will be to minimise delays and improve resilience and predictability for capacity-constrained high-density/complexity TMAs. This will be achieved by enhancing arrival and departure management by the dynamic use of precision navigation routes and optimised profiles. Traffic flows will be optimised by improving the integration of the management of departures with arrivals, including extended Arrival Manager (AMAN) and ground holding from in-horizon departures, and by improving the capability to balance traffic demand and available capacity across the network and airports.The use of procedures and technologies to improve integration of rotorcraft operations within TMAs, and interoperability with General Aviation (GA), drones and Remotely-Piloted Aircraft System (RPAS), will be addressed which will also provide increased resilience in poor weather.To ensure that the full benefits are achieved and that the expected performance improvements are realised in the context of the overall ATM network, close co-ordination will take
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Low-Cost Diagnostics Monitoring Technology' (DIADEM), addressing dissemination and exploitation.

assistant: **Impact**

Convenience of measuring blood values without need of going to hospital has driven the market in developing several point-of-care blood testing products, which improve patients’ conditions, accessibility to data, and health status awareness (e.g. in diabetes type II monitoring). The biggest challenge that POCT faces is the still low adoption rate by the medical users. Three main adoption barriers nowadays prevent large-scale diffusion of blood-testing POCT in the European market: 1) Equipment Cost: it currently requires around 2 years for paying back the initial investment. The market requires products that can become profitable in much shorter time. 2) Product operability: most of the devices in the market still require manual sample preparation steps, needing trained operators and prone to procedural mistakes, which slow time to result and affect measurement accuracy. 3) Tests availability: Usually POCT devices can measure just very few parameters, forcing users to purchase different machines for different blood tests. Our product, the SenseLab, is designed to provide a simple, reliable and affordable solution for POCT monitoring of diabetes type II–related blood parameters, and beyond. The core of our product is our versatile patented bio-detection technique, the Sense-Ray technology, which allows very precise quantification of multiple biomarkers with extremely simple equipment, built on inexpensive off-the-shelf components. The proposed DIADEM project will provide BluSense management with a very clear landscape of the go-to market approaches which can be taken in the different EU market segments. The objective is to strengthen, via thorough analysis of the individual Europe market segments and geography, the best distribution and cost-structure opportunities for Bl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Reclamation of Gallium, Indium and Rare-Earth Elements from Photovoltaics, Solid-State Lighting and Electronics Waste'.

assistant: **Concept**

Prospective global supply and demand for gallium, indium and other key metals show an increasing discrepancy, amongst others due to the explosive growth of green technologies such as photovoltaics (PV) and solid-state lighting (SSL). While their primary production is highly controlled by a few countries, recycling systems to reclaim these materials from discarded products are not yet in place. This makes Europe susceptible for the provision of materials that are crucial for meeting policies on energy saving and renewability, as well as challenges the further development of the concerned industrial sectors.Hence there is a strong need to establish recycling systems for PV, SSL and other electronic waste and capitalise on these as yet unexploited and growing deposits of key materials. The bottlenecks are in the disconnection and sorting of the parts with the targeted materials from the waste and in the release, concentration and purification of the reclaimed metals. More in particular, the concerned materials tend to be used as compounds (gallium arsenide, gallium nitride, indium tin oxide) rather than in their elemental form and to be applied as thin layers on substrates in overall very low amounts.Objectives of the proposed project are (1) technological solutions that relieve current bottlenecks in the recycling of gallium, indium and rare-earth elements, and (2) demonstration of their application potential by means of a pilot implementation in an industrial setting. The project is to result in separation methods for electronic assemblies that reduce manual work (>80% automation) as well as in subsequent recovery methods that yield recycled materials of commercial-grade quality (>99-99.99%, depending on the element), apt to fit an industrial context and being environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Testing the predictions of ecological speciation in sticklebacks' (ECOSPEC), addressing dissemination and exploitation.

assistant: **Impact**

The process of speciation is central to biology because it is responsible for the diversity of life. However, progress in finding general mechanisms for species formation has been slow. One potential solution is ecological speciation, in which adaptation to alternate environments generates reproductive isolation between populations.Our project will test three key predictions of ecological speciation with stickleback fish from British Columbia, Canada. First, can adaptation to alternate environments generate reproductive isolation? This might occur because their mating systems have diverged, or because hybrids fall between ecological niches. In particular, we will focus on detecting assortative mating between geographically isolated stickleback fish that have adapted to different niches.Second, are traits that differ between populations under divergent selection? If so, these traits can contribute to reproductive isolation by reducing hybrid fitness: hybrids will be poorly adapted for either parental habitat. We focus on sticklebacks from lakes where two alternately adapted species co-exist (the limnetic-benthic species pairs), and determine whether there is predator-mediated divergent selection acting on the quantitative trait loci responsible for two anti-predator traits. Both experiments will be conducted with Dolph Schluter at the University of British Columbia, Canada.We will then explore whether divergent selection on these anti-predator traits has been responsible for reducing hybrid fitness in the species pair lakes. This selection will reduce gene flow around each locus, and this should be detectable at the DNA level. As this requires the application of coalescent models of selection and gene flow, I will work with Thomas Lenormand at CEFE in Montpellier, France
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Numerical treatment of stochastic functional differential equations'.

assistant: **Innovation**

Research objectives and content In this project stochastic functional differential equations (SFDEs) will be considered. These equations play an important role in modelling f.e. population dynamics, stochastic control systems and investment financing, when time delays and stochastic effects have to be taken into account. The analytical theory of SFDEs is relatively well developed, as is the analytical and numerical theory of deterministic functional differential equations (FDEs) and stochastic ordinary differential equations (SODEs). The aim of my project is to develop and analyse numerical methods to solve SFDEs with special emphasis on stochastic delay differential equations (SDDEs). I want to investigate how methods used for FDEs and SODEs can be brought together to yield methods for SFDEs. The objective is to seek a collection of representative model equations with well-known SODE and FDE counterparts and to provide a robust adaptive code for that class of SFDEs. The programmepackage will be made available via internet. Training content (objective, benefit and expected impact) I will gain from the considerable expertise in Manchester on the numerical solution of ordinary and delay differential equations, which for me is a new area of research. Furthermore I can benefit from the fact that the group has links with workers on stochastic equations. I will get experience in a relatively new, but important (espesially with regard to more precise modelling) area of research. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Law Enforcement agencies human factor methods and Toolkit for the Security and protection of CROWDs in mass gatherings' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

LETS–CROWD will overcome challenges preventing the effective implementation of the European Security Model (ESM)  with regards to mass gatherings. This will be achieved by providing the following to security policy practitioners and in particular, LEAs:(1) A dynamic risk assessment methodology for the protection of crowds during mass gatherings centred on human factors in order to effectively produce policies and deploy adequate solutions. (2) A policy making toolkit for the long-term and strategic decision making of security policy makers, including a database of empirical data, statistics and an analytical tool for security policies modelling, and(3) A set of human centred tools for Law Enforcement Agencies (LEAs), including real time crowd behaviour forecasting, innovative communication procedures, semantic intelligence applied to social networks and the internet, and novel computer vision techniques.LETS-CROWD will be a security practitioner driven project, fostering the communication and cooperation among LEAs, first responders, civil protection and citizens in the fight against crime and terrorism during mass gatherings by a set of cooperation actions. The project will put citizens at the centre of the research and will assess and evaluate how security measures affect them, and how they perceive them, while respecting EU fundamental rights.LETS-CROWD impact will be measured under practical demonstrations involving seven LEAs and relevant emergency services units. In order to facilitate the assessment of the performance, transferability, scalability and large scale deployment of these solutions, the demonstrations will be conducted following eleven use cases.


**Keywords:** human factor, european security model, security, law enforcement agencies, emergency servic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Unconventional NMDAR signaling theory for Fragile X Syndrome'.

assistant: **Objectives**

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability (ID), and the leading known genetic cause of autism. This dominant phenotype represents a huge hindrance for clinicians in the treatment of FXS because the underlying neuronal deficits remain unknown. Individual neurons store information as we learn and acquire new information by modifying their connections with nearby neurons, a process called synaptic plasticity. This refers to activity-dependent long-term changes in synaptic strength but also synaptic structure, and is highly regulated by NMDA receptors (NMDAR). It has recently been proposed that NMDARs can signal in an unconventional manner. Our goal is to understand how unconventional NMDRs drive synaptic plasticity, and how this is dysregulated in the mouse model of FXS. For this, we will record electrical activity of the neurons and image synaptic structures during different forms of synaptic plasticity, and characterise metabotropic NMDAR signaling by functional genomic approaches. In summary, we will use a multi-disciplinary approach to unravel the mechanisms responsible for synaptic plasticity alteration in the mouse model for FXS and further our understanding of the neuronal processes underlying cognitive phenotypes of FXS. The outcomes of these experiments will not only offer hope to patients with FXS but will also further our understanding of the molecular basis of synaptic plasticity. If successful, this could serve as the basis for future molecular targets to promote cognitive recovery from ID, autism spectrum disorders and other diseases.The project is an excellent opportunity for the researcher to further develop her knowledge and to position her in unique multidisciplinary environment that will foster her career prog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Impact Aware Manipulation by Dexterous Robot Control and Learning in Dynamic Semi-Structured Logistic Environments' (2014-2020).

assistant: **Innovation**

Europe is leading the market of torque-controlled robots. These robots can withstand physical interaction with the environment, including impacts, while providing accurate sensing and actuation capabilities. I.AM leverages this technology and strengthens European leadership by endowing robots to exploit intentional impacts for manipulation. I.AM focuses on impact aware manipulation in logistics, a new area of application for robotics which will grow exponentially in the coming years, due to socio-economical drivers such as booming of e-commerce and scarcity of labor.I.AM relies on four scientific and technological research lines that will lead to breakthroughs in modeling, sensing, learning and control of fast impacts: 1) I.Model offers experimentally validated accurate impact models, embedded in a highly realistic simulator to predict post-impact robot states based on pre-impact conditions; 2) I.Learn provides advances in planning and learning for generating desired control parameters based on models of uncertainties inherent to impacts; 3) I.Sense develops an impact-aware sensing technology to robustly assess velocity, force, and robot contact state in close proximity of impact times, allowing to distinguish between expected and unexpected events; 4) I.Control generates a framework that, in conjunction with the realistic models, advanced planning, and sensing components, allows for robust execution of dynamic manipulation tasks.This integrated paradigm, I.AM, brings robots to an unprecedented level of manipulation abilities. By incorporating this new technology in existing robots, I.AM enables shorter cycle time (10%) for applications requiring dynamic manipulation in logistics. I.AM will speed up the take-up and deployment in this domain by validating its progress in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Let restore our soils : using the soil food web to engineer the soil structure and functionning', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Rationale: Soils are precious for human health and food production but 33 % of the world soils are degraded. Developing ecological engineering strategies to restore them is an urgent need. Soil structure is a key aspect of soil functioning, with soil aggregates being organo-mineral associations, constituting its building bricks. The influence of soil organisms on soil aggregation is commonly acknowledged but supported by little direct mechanistic evidence, which are mainly single group approaches, hence not depicting the role of the complex soil biota.Aim: The aim of this MSC project is to directly link the soil food web properties to the formation of soil aggregates, with subsequent consequences on the restoration of soil functioning. The novelty of this project is that it will provide direct mechanistic evidence of how species interactions – and not only diversity – can influence a key soil process: the formation of aggregates. The resulting knowledge will provide basis for developing soil ecological engineering techniques to restore degraded soil via soil biota manipulation. Methodology: Unravelling such mechanistic understanding will require a multidisciplinary approach merging soil animal ecology and soil physics. The project will be hosted by the University of Göttingen in Germany, providing unique access to soil ecology and physics lab facilities. Two experiments, respectively manipulating targeted trophic interactions (bacteria-amoebe and fungi-collembola) and natural soil food web complexity (tracked by isotope tracing, PLFA, etc.) will be run in microcosms and mesocosms, and resulting changes in soil aggregate properties and soil functioning will be assessed by cutting edge physics techniques, such as neutron radiography and X-rays tomography. A secondment per