RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multi-disciplinary Comparison of Fluid Venting from Gas Hydrate Systems on the Mediterranean and Brazilian Continental Margins over Glacial-Interglacial Timescales' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Gas hydrates are ice-like compounds that form within near-seabed sediments on continental margins, concentrating greenhouse gases (mainly methane) within what is estimated to be the largest reserve of hydrocarbons on Earth. The stability of this frozen sub-oceanic reservoir is sensitive to changes in sea-level and temperature over time, but also to the poorly understood dynamics of chimney-like structures observed to vent gas to the oceans. An understanding of gas venting from hydrates over time is of  scientific and social relevance, due to potential impacts on global carbon budgets, regional geohazard assessments and future energy resources. SEAGAS is the first project to propose a comparative analysis of gas hydrate systems on continental margins that have experienced differing forms of glacial-interglacial climate forcing: an open ocean (the South Atlantic) and a semi-enclosed sea (the Mediterranean). The project will perform numerical modeling of changes in gas hydrate stability on both margins, to guide analyses of marine geophysical, geological and geochemical datasets held by the outgoing and return hosts, as well as of data to be obtained during a joint acquisition campaign to the Nile fan. SEAGAS leverages ongoing high-level research programmes by the outgoing and return hosts, which offer multi-disciplinary expertise and datasets, as well as access to ship-time. The key training objective is for the researcher to acquire new skills in marine geochemical concepts and methods with the Brazilian host, in order to broaden his existing competencies (and those of the French host) in marine geophysics and geology. SEAGAS has the strategic objective of consolidating a nascent collaboration between the outgoing and return hosts, with strong potential for further colla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'EuroREACH A Handbook to Access Health Care Data for Cross-country Comparisons of Efficiency and Quality' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

EuroREACH explores how coordination among recent innovations for better health care information systems and performance measurement at a national, European and international level can lead to improved access to data for cross-country, comparative research. This will be undertaken for a broad range of questions into the efficiency, quality and equity of health care services, following a patient-centred, disease-based approach. Better integrated health care in order to improve quality and cost-effectiveness of health services across providers and care settings is a major policy concern in the EU.EuroREACH comprises coordination activities for three types of initiatives to improve data access for research:1. European and international initiatives and research projects;2. National practice of innovative health information and performance management systems;3. European and international data systems and new ways to link them to national sources and to qualitative structural indicators of health care systems for comparative analysis.Expert panels and two Sounding Board Conferences will support the project, by providing input and by reviewing progress. They will also be involved in broad dissemination.Results will include guidance for researchers to data access; policy lessons on good practice of national and international performance measurement and information system design, including questions of data linkages, data protection and mapping to international classifications and data framework. The outcome will be synthesised in a handbook entitled “EuroReach: Handbook to Access Health Care Data” that will serve as a generic guide to data access for researchers, other data users and stakeholders. It will also provide guidance to policy makers, discussing options for governing a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'TARGETING ENDOTHELIAL CELL AND CANCER AMOEBOID MOVEMENT TO OVERCOME RESISTANCE TO ANTI-VEGF AND ANTI-PROTEASE THERAPIES' to be submitted under Horizon 2020.

assistant: **Abstract**

Unlike mesenchymal migration, the amoeboid motility doesn’t require proteases and is an opportunistic movement of cancer cells which allows cells to glide through, rather than degrade, ECM barriers, using movements based on adaptations of the cell body. Preliminary experiments we conducted using a mixture of physiologic inhibitors of serine-proteases, metallo-proteases and cysteine-proteases, thus mimicking a physiological environment, showed no differences in vessel formation for both Endothelial Progenitor Cells (EPCs) and mature Endothelial Cells (ECs) under mesenchymal or amoeboid conditions. Thus, we hypothesized the existence of an “amoeboid angiogenesis”. We also hypothesized that the failure of cancer treatment using synthetic metalloproteinase inhibitors (MPIs) could be ascribed to the ability of cancer and ECs to skip the attack of the MPI therapy by allowing cancer invasion and blood vessel formation using the “amoeboid” strategy. Even the VEGFA targeting partially disregarded the expectations because of the resistance onset followed by the progression of the disease. Our preliminary experiments showed also an “indifference” of ECs and EPCs to VEGF stimulation under amoeboid conditions. Therefore, the aim of this project is to identify the multiple mechanisms shared by cancer cells and ECs/EPCs in the regulation of amoeboid movement, to identify common therapeutic strategies impairing vascular growth and cancer cell invasion at the same time, overcoming resistance to anti-VEGF and anti-protease therapy. The molecules identified (ephrin, protease receptors, etc.) will be used as candidates for targeted therapy through the delivery of cargo liposomes containing inhibitors of the connection of such molecules with the cortical actin cytoskeleton, in pre-clinical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Microscale enabled advanced flow and heat transfer technologies featuring high performance and low power consumption'.

assistant: **Innovation**

With the emergence of Industry 4.0, electronic and digital devices are incorporated into almost all high tech applications. There has also been a notable shift towards compact electronic devices, which requires more intense operating powers — leading to enormous heat dissipation. Thus, whilst devices are increasingly becoming portable and powerful, thermal management techniques are arguably not catching up at the same rate. Hence, continuous improvement and innovative approaches are needed. In this regard, microchannel-based techniques present innovative possibilities to tackle thermal management and cooling issues in modern appliances across various industries, aligning with the trend to adopt more sustainable approaches and the EU 2016 legislation for heating and cooling. Consequently, our 'Micro-FloTec' project adapts an international, multidisciplinary, and collaborative approach to exchange expertise from 17 research institutions and two industrial partners to trigger significant advancements and agile development for heat transfer and thermal management solutions. The consortium shares robust experience and skills related to heat transfer enhancement, large-scale electrical energy storage via thermal processes, new generation materials science, multi-phase flow, flow and heat transfer of high-temperature rotating parts, design and modelling for energy-efficient control systems, marketing and entrepreneurship skills, amongst others. Based on the appraisal of the current state-of-the-art literature and technologies, we aim to tackle problems within morphological optimization of multiphase heat transfer performance and flow resistance reduction, surface modification techniques, and application of multi-phase physics for performance prompting. Our project will hopeful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Electrical Petrology: tracking mantle melting and volatiles cycling using electrical conductivity'.

assistant: **Objectives**

Melting in the Earth’s mantle rules the deep volatile cycles because it produces liquids that concentrate and redistribute volatile species. Such redistributions trigger volcanic degassing, magma emplacement in the crust and hydrothermal circulation, and other sorts of chemical redistribution within the mantle (metasomatism). Melting also affects mantle viscosities and therefore impacts on global geodynamics. So far, experimental petrology has been the main approach to construct a picture of the mantle structure and identify regions of partial melting.Magnetotelluric (MT) surveys reveal the electrical properties of the deep Earth and show highly conductive regions within the mantle, most likely related to volatiles and melts. However, melting zones disclosed by electrical conductivity do not always corroborate usual pictures deduced from experimental petrology. In 2008, I proposed that small amount of melts, very rich in volatiles species and with unusual physical properties, could reconcile petrological and geophysical observations. The broadening of this idea is however limited by (i) the incomplete knowledge of both petrological and electrical properties of those melts and (ii) the lack of petrologically based models to fit MT data. ELECTROLITH will fill this gap by treating the following points:- How volatiles in the H-C-S-Cl-F system trigger the beginning of melting and how it affects mantle conductivity?- What are the atomic structures and the physical properties of such volatile-rich melts?- How can such melts migrate in the mantle and what are the relationships with deformation?- What are the scaling procedures to integrate lab-scale observations into a petrological scheme that could decipher MT data in terms of melt percolation models, strain distributions and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Infrared surface brightness fluctuactions - distance scale and constraints on extragalactic stellar populations' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content We propose to calibrate and apply infrared (1-2.5pim) surface brightness fluctuation (SBF) measurements of galaxies as a cosmological distance indicator, addressing the problem thoroughly from an observational perspective using several telescopes including the Hubble Space Telescope (HST) and Keck 10-m telescopes and from a theoretical perspective using the most advanced galaxian stellar population models developed at the Institut d'Astrophysique de Paris. Unlike most cosmological distance indicators, surface brightness fluctuation (SBF) measurements are appealing because of their well-understood physical basis; SBF work at optical distances has been developed as a useful distance indicator over the last 10 yr. As SBFs of ellipticals are dominated by late-type stars, infrared (IR) measurements with the Keck telescopes offer the potential to measure distances 2-3 times as far as previous optical SBF work. Using state-of-the-art stellar population models, we will investigate the predicted behavior of IR SBFs with stellar population variations and compare with observations. A primary motivation for this project is to provide the European community with the best tools for exploiting some of the outstanding capabilities of the upcoming Very Large Telescope (VLT). Distance measurements out to 100 h-1 Mpc and consequently, a value of the Hubble constant uncontaminated by local peculiar velocities seem within reach. Training content (objective benefit and expected impact) Beyond the immediate scientific return described above, the significant improvement of stellar population models widely used by the European cosmological community will have considerable impact for exploiting the capacilities of the ESO/VLT that will be operational in 1998. Link
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding and predicting developmental language abilities and disorders in multilingual Europe' in the context of a Horizon 2020 call.

assistant: **Objectives**

PredictAble aims to train a new generation of young scientists at the crossroads between academic research, technological development in the private sector and clinical practice to pioneer an interdisciplinary approach to language related developmental disorders, like specific language impairment (SLI) and developmental dyslexia (DD). The innovative and timely research program will enhance the understanding of the cognitive mechanisms that underlie developmental disorders of spoken and written language by pooling international experts from academia and the private sector. For the first time, PredictAble applies a truly multidisciplinary and cross-linguistic perspective with a unique and novel combination of cutting-edge approaches and techniques for studying mono- and bilingual children. Thus, PredictAble will provide young researchers with an excellent foundation for making scientific progress in this area, in collaboration with technology development and the transfer of research outcomes to applicants in the private sector and the health sector/clinical practice. Highly recognized experts in the area of language acquisition in very young mono- and bilingual children will work together on the acquisition of spoken and written language in a cross-linguistic approach. The complementarity of the different languages in PredictAble will make it possible to identify language-specific and cross-linguistically valid effects. In cooperation with technological partners from the private sector, PredictAble will optimize recently developed technologies in the area of developmental cognitive neuroscience to render them suitable for use with very young children and as diagnostic tools to detect early risks for language-related impairments.


**Keywords:** bilinguals, specific langua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Investigation of a Novel Dew Point Cooling Heat and Mass Exchanger for Air Conditioning of Buildings in Europe'.

assistant: **Innovation**

The conventional air conditioning systems are neither sustainable nor environment-friendly. Evaporative cooling utilizes an ambient energy (latent heat of water evaporation) to perform air conditioning of buildings, and is therefore a potential replacement of existing systems. However, evaporative cooling has several technical difficulties that impede its wide application. Direct evaporative cooling adds moisture to room air which causes unpleasant thermal comfort. Indirect evaporative cooling limits supply air temperature to some degrees above the wet bulb of the outdoor air, which is too high to perform air conditioning of buildings. The dew point (evaporative) cooling breaks the limit of wet bulb, and allows the supply air to be cooled to a level below the wet bulb and above the dew point of the outdoor air. However, the existing exchanger for dew point cooling is still less efficient to perform air conditioning of buildings in Europe regions. The proposed research aims to optimise the design of the exchanger in terms of its material, structure and geometric sizes, and to develop a new polygonal-sheets-stacked exchager. The new exchanger will be 15 to 35% higher in cooling effectiveness that allows the dew point cooling become a widely applicable system for building air conditioning in most regions of Europe. The project objectives include (1) Optimisation of the exchanger design, (2) Construction and testing of the exchangers, and (3) Economic, environment and local acceptance analyses. The fellowship will benefit the applicant researcher in terms of enhanced research ability and integration with host institution. It will also benefit the host institution in terms of knowledge transfer and strengthening international collaboration. The project will benefit to EU in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Genome-wide CRISPR/Cas9 screen in intestinal organoids for identification and molecular characterization of therapeutic targets to enhance tissue regeneration' under Horizon 2020.

assistant: **Concept**

Around 3 million people in Europe are affected by inflammatory bowel disease (IBD), a devastating condition characterized by chronic inflammation of the digestive tract causing severe damage to the intestinal epithelium. Current medication strategies aim to relieve symptoms by reducing the inflammatory burden without promoting epithelial repair to restore tissue integrity. It is therefore of great importance to enhance the current understanding of intestinal regeneration and thus facilitate the development of novel pharmaceutical compounds to improve tissue recovery in IBD patients. However so far, only few regulators of intestinal regeneration with quite distinct cellular functions have been identified, suggesting an interplay of various molecular pathways that orchestrate intestinal repair. This therefore raises the question of which cellular and molecular mechanisms safeguard epithelial regeneration. To address this issue, I will combine a unique in vitro organoid system, developed in the host lab that captures epithelial cells in a regenerative state, with my expertise in large-scale screening approaches to: (1) perform an unbiased genome-wide CRISPR/Cas9 screen to identify novel regulators of intestinal regeneration, (2) validate essential pathways in intestinal repair in vitro and in vivo, and (3) dissect the molecular events coordinating tissue healing. The outcome of this project will on one hand provide a comprehensive list of factors and their molecular function controlling this cellular process and on the other hand uncover novel druggable pathways in IBD to enhance the regenerative capacity of the intestinal epithelium. Executing this MSCA fellowship proposal will equip me with expert knowledge in epithelial biology and associated pathologies, cutting-edge t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Strategic Assessment of Corridor Developments, TEN Improvements and Extensions to the CEEC/CIS' (CODE-TEN), addressing dissemination and exploitation.

assistant: **Impact**

The general aim of the CODE-TEN project is to assist with decision-making in the complex environment of contemporary transport geography characterised by the new concept of 'corridor'. It will provide a comprehensive strategic assessment methodology that can apply to corridors and will seek to identify and present major policy-related issues and the associated scenarios and assumptions in a consistent way. %The specific objectives of the study will be: (a) To compile policy-relevant information and data on transport corridor and TEN developments (including extensions to the CEEC/CIS) in a longer-term perspective; (b) using this information to update, correct and elaborate existing scenarios on infrastructure development and transport policy scenarios; elaborate comparable parameters concerning the spatial, temporal and socio-economic impacts of corridor developments in the greater European area under study; and to compile relevant (spatial) environmental impacts and indicators; (c) subsequently, to define a comprehensive methodology to be used for the assessment of transport policies and larger projects, namely networks and corridors, and which is compatible with SEA; (d) on the basis of the application of this methodology, to define and develop policy assistance tools (presented in a report/manual and an interactive computer programme) for assessing interactions between policy instruments and corridor/network developments.Corridor Case StudiesSt. Petersburg--Helsinki-Stockholm-Copenhagen;Warsaw-Riga-Tallinn-Helsinki 'Via Baltica';Berlin-Warsaw-Minsk-Moscow-Nizhny Novgorod;Danube waterway;Berlin-Prague-Vienna-Budapest-Sofia-Constanta/Thessaloniki;Salzburg-Ljubljana-Zagreb-Beograd-Thessaloniki;Venice-Triest/Koper-Budapest-Kiev;Mediterranean short-sea shipping;Lisbon-Madr