RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'THREE STOP CODONS TO GET OVER TO FLOURISH' (3Stops2Go).

assistant: **Concept**

An accumulating body of evidence reveals that the Genetic Code, canonically interpreted in codons of three nucleotides, is not universal. In dogma challenging findings, we have observed in unicellular protists a remarkable malleability of genetic decoding that is mostly governed by tRNAs that interpret codons as having different meanings depending on their location in the genome. For example, coding sequences of our model protist Blastocrithidia nonstop are rich in stop codons and unique tRNA architectures are employed to readthrough them efficiently. Importantly, these internal stops very much resemble premature termination codons (PTC) in humans that lead to truncated proteins and are the cause of ~11% of human genetic disease. As such, these small RNA molecules with innate readthrough properties hold tremendous promise for the treatment of disease.Our first objective is to explore and characterize the molecular mechanisms of alternative genetic decoding in protists where this phenomenon is most prominent. Armed with this knowledge, our second objective is to engineer tRNAs and tRNA-specific readthrough-inducing drugs (TRIDs) for programmable alterations of genetic decoding in heterologous systems. tRNAs and TRID will then be applied in cellular and animal models of severe monogenic paediatric diseases.We have assembled a team that synergizes expertise across disciplines. JL is a leading protist biologist, LV specializes on translational control, ON in engineering stop codon readthrough drugs, and MO in clinical disease models. This intertwined collaboration of all four PIs will expedite the characterization of alternative decoding mechanisms and their ultimate application in cellular and in vivo models of human diseases. Successful completion of 3Stops2Go is only pos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Towards an integrated strong motion modelling : comparison of source, path and site effects on the example of euroseistest data'.

assistant: **Concept**

Foreseen ResultsThis project is thus expected to produce carefully validated computer codes for ground motion modelling, with due consideration to source, path and site effects, which should in turn result in an improved assessment of seismic actions for civil engineering structures.Recent destructive earthquakes have repeatedly shown that one of important cause of the occurrence of disaster (even in developed countries) was the underestimation of ground motion, or of certain of their characteristics. The research objective of this proposal is the improvement of the ground motion estimates through a careful and validated integration of already existing numerical modelling techniques, that take proper account of all the physical phenomena affecting the amplitude and spectral characteristics of seismic waves, without overemphasizing or minimizing any of them.One important goal of the present proposal is thus to merge the various numerical techniques developed separately in each of the 4 involved teams, and whose original aim was to investigate one particular effect (various source effects or crustal effects, or one category of site effects): these techniques include ray methods, finite-difference (FD) techniques, discrete wave-number method (DWN), matrix (1D) methods, empirical Green's function methods (EGF) and non-linear methods (NL). However, in order to have physical constraints on the way to merge these techniques, and on the respective importance of the effects they separately model, this integration will be extensively tested against high quality, well constrained instrumental data.The research activities will start with a careful selection of some data sets from the weak and moderate events recorded by the Volvi lake arrays, and the translation of all the seismolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Patient empowered Diabetes care in ambulatory settings' (PaDiCare).

assistant: **Concept**

Atonomics and InTeleCare4U’s joint vision is to bring Trace to market, a Point-of-Care (POC) blood biomarker monitoring system for Diabetes Mellitus (DM) that syncs highly accurate and precise lab results to hospital’s electronic patient record (EPR). Trace has such a simplified user experience that patients can perform their own blood analysis without nurses performing the blood draw or lab staff analysing the sample. Trace analysis require just a drop of blood obtained through finger-pricking, the same procedure that diabetic patients use for daily glucose monitoring. Analysis runs automatically in a very short time (5-7 min per biomarker) and the results are then synced to doctors’ PC / tablet through ITC4U’s data sync services – based on the open source OpenTele platform. Trace system combines the following three key elements for effective and resource-efficient monitoring:- Trace device, an easy to use, lab-grade device to measure HbA1c and lipid panel biomarkers for DM monitoring;- Trace tablet app, a step-guided application that helps patients use the Trace device, and collects the results from Trace;- ITC4U’s secure sync infrastructure that transmits patient data collected in app directly to the doctor’s tablet or PC.With the growing share of DM patients, the availability of clinicians will become a bottleneck for proper care. Patient involvement in these analyses is the best option for sustainability of care. Trace addresses this market. The short assay run time means that patients can perform blood analysis just before their regular appointments, already at the ambulatory unit, saving hours in waiting rooms and trips to labs. Hospitals benefit from faster patient turnover, providing care to more patients with the same resources (i.e. higher efficiency and high
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'SKeletal Muscle - REgulation of FORce and Maturation through Tubulin isotypes'.

assistant: **Concept**

Microtubules are formed by polymerization of tubulin heterodimers. Tubulin monomers rise from 16 genes each with their own spatiotemporal signature, resulting in a patterned microtubule network. As tubulin dimers define binding microtubule associated proteins (MAPs) and occurring post-translational modifications (PTMs), I wonder whether microtubule properties and patterns are encoded/defined by the tubulin isotypes themselves. This proposal aims at 1-confirmation of the expressed tubulin isotypes in skeletal muscle, depending on developmental stages, sex, and fiber type. 2-Understanding of how tubulin isotypes contribute to macroscopic phenotypes such as myoblasts fusion, general fiber organization and muscle contraction. 3-Deciphering of the molecular mechanisms at play upon tubulin isotype loss-of-function. 4-Assessement of potential beneficial effects of tubulin loss-of-function in diseases such as Duchenne muscular Dystrophy (DMD), Centronuclear Myopathy (CNM), and myasthenia. Using innovative in vitro differentiation tools, animal models and state of the art microscopy, I will explore all potential effects of selected tubulin isotypes, from macroscopic phenotypes to molecular mechanisms, as well as in disease. Expected techniques to use are: RT-q-PCR, co-cultures motoneurons-myoblasts, CRISPR/Cas9 mediated KO, shRNA KD, gene transfer by AAV injection, force measurement in vivo and ex vivo, immunohisto- and cytochemistry, live-imaging with fluorescent probes, and image analysis. Microtubule and tubulin being involved in many types of diseases (cancer, development, degeneration…) this project will lead to many economic, social and therapeutic benefits.


**Keywords:** microtubules, tubulin isotypes, skeletal muscle, post-translational modifications, motor unit, iPSCs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Dictatorship, Hierarchy, and the Stalinist Economy: the Soviet Defence Industry 1929 -1953'.

assistant: **Concept**

The project will investigate the forces shaping the working arrangements of Stalin¿s dictatorship in the Soviet economy, using the detailed documentation now available in the Russian state and economic archives as its evidence base. Its ultimate motivatio n is to understand how a dictator chose to rule subject to the resources available and other constraints that limited his choices, and the influences on his choices that arose from within his own regime. The working arrangements of Stalin¿s regime were hi ghly variable over time. It appears that Stalin exercised choice between two principal means of securing the compliance of his agents and so enforcing his rule: a small apparatus that relied on terror, or a larger apparatus that relied less on terror, more on the provision of assistance and rewards. A larger apparatus that provided assistance and rewards was expensive, but terror also had costly repercussions. Officials at lower levels had their own preferences. Investigation will focus specifically on the defence industry, notable for its high priority and the detailed attention that it received from Stalin and his colleagues. The research will examine the interests and motivations at work at higher and lower levels of the apparatus, and their interaction. Starting from existing theories of the political economy of dictatorship using principal-agent models and simple games, the methodology of the research will be to develop further theoretical insights using newly available historical evidence, largely quali tative in character, to substantiate or modify assumptions and test predictions. The scientist in charge is an established EU-based scholar while the applicant is a young Russian researcher of great promise. The host institutions, the University of Warwick and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Detection and identification of nanoplastics in water via plasmonic-based spectrometric methods using evaporation-driven colloidal assembly' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In recent years, we have discovered that our environment is extensively polluted with plastic particles in a wide range of sizes, from the largest pieces that we can identify with our bare eyes, to the so called “microplastics” (< 5 mm).  As a consequence of the improvement in detection techniques, we now know that, for example, up to trillions of microplastic particles per litre have been found in plastic bottles for infants and in general plastic-based consumer water containers. Plastic debris above the microplastic cut-off can be sampled easily (though tediously) using standard extraction, collection, and purification methods. However, microplastics are typically heavily underestimated when using such basic techniques. In this project, I intend to develop a technique by which we can (1) concentrate diluted pre-filtered solutions by a controlled droplet evaporation process and (2) perform chemical identification of its content beyond the current detection limits using surface enhanced Raman spectroscopy. The technique will be easy, fairly cheap to implement and easily scalable for the identification of micro- and nanoplastics in consumer products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A Study of the Notion of Ampleness in Model Theory and Tits Buildings'.

assistant: **Innovation**

The proposed project AMPLE allocates in the area of mathematical Logic, Model Theory. It aims to develop a full understanding of the notion of ampleness and establish new connections between Model Theory and core mathematics.Model Theory aims to study and classify mathematical structures according to their THEORIES, that is, the class of all first order logic sentences that are true within them. One of the most important conjectures within Model Theory is Zilber's Trichotomy Conjecture, which suggested a classification of so-called strongly minimal structures - the building bricks of large classes of first order structures. Even though having been refuted quickly after its formulation, this conjecture and its counter example by Hrushovski have shaped the research in model theory and ultimately led Hrushovski to his outstanding proofs of the Mordell-Lang Conjecture, originating in the area of Number Theory. The notion of AMPLENESS was developed in order to classify the geometries left out in the Trichotomy Conjecture. Even though studied by many after its introduction, there is a plethora of open questions around this notion, witnessing that a thorough understanding is still missing. Answers to these questions have the potential to reshape the view on the classification of first order structures. The ER managed in her PhD thesis to solve one of the main open problems in this area, by combining tools from the field of TITS BUILDINGS, which was developed to classify simple algebraic groups and groups of Lie type. Together with the project Supervisor, who is a leading expert in the area of ampleness, the ER will establish a full understanding of the notion of ampleness, using its close connections to the theory of Tits Buildings. This project promises new bonds between Mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Political Process Preferences in Europe: Rethinking Conceptual, Ontological and Methodological Foundations' under Horizon Europe.

assistant: **Concept**

To understand the levels of dissatisfaction with democratic performance in Europe, as well as the most effective reforms for addressing it, requires an understanding of citizens’ process preferences: how do they want democracies to function? Empirical research on process preferences is rapidly proliferating, but it has been underpinned by an assumption that the task of this research is to discover which one of a set of abstract, normative models of democracy citizens subscribe to. The driving idea behind PoPPiE is that this assumption is a serious limitation. It has led the study of process preferences to focus on discrete choices between simple alternatives that fail to represent the real choices facing the inhabitants of complex democratic systems and neglected the extent to which individuals are conflicted between competing democratic norms. It prevents robust inferences on important questions, such as levels of polarisation and support for democratic innovations.PoPPiE develops a groundbreaking new approach to rethink the conceptual, ontological and methodological foundations for researching political process preferences. - First, by applying democratic systems theory to re-conceptualise the content of process preferences it will generate a wholly new conceptual understanding of preferences for complex democratic systems, rather than ideal models of democracy. - Second, instead of assuming that the nature of process preferences is inherently ideological, PoPPiE uses a novel multidimensional theoretical framework to assess levels of contextuality, conditionality and coherence in process preferences. - Third, it develops a new mixed methods approach, producing a unique dataset that combines qualitative and quantitative data on a single individual’s preference.The new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exascale Programming Models' under Seventh Framework.

assistant: **Concept**

Exascale computing power will likely be reached in the next decade. While the precise system architectures are still evolving, one can safely assume that they will be largely based on deep hierarchies of multicore CPUs with similarly-deep memory hierarchies, potentially also supported by accelerators. New and disruptive programming models are needed to allow applications to run efficiently at large scale on these platforms. The Message Passing Interface (MPI) has emerged as the de-facto standard for parallel programming on current petascale machines; but Partitioned Global Address Space (PGAS) languages and libraries are increasingly being considered as alternatives or complements to MPI. However, both approaches have severe problems that will prevent them reaching exascale performance.<br/>The aim of this proposal is to prepare Message Passing (MP) and PGAS programming models for exascale systems by fundamentally addressing their main current limitations. We will introduce new disruptive concepts to fill the technological gap between the petascale and exascale era in two ways:<br/> First, innovative algorithms will be used in both MP and PGAS, specifically to provide fast collective communication in both MP and PGAS, to decrease the memory consumption in MP, to enable fast synchronization in PGAS, to provide fault tolerance mechanisms in PGAS, and potential strategies for fault tolerance in MP. Second, we will combine the best features of MP and PGAS by developing an MP interface using a PGAS library as communication substrate.<br/>The concepts developed will be tested and guided by two applications in the engineering and space weather domains chosen from the suite of codes in current EC exascale projects. By providing prototype implementations for both MP and PGAS c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Beyond hydrodynamics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

What do black holes and particular exotic materials, where strong correlations preclude any description based on weakly-coupled quasiparticles, have in common? Their low energy dynamics are expected to fall within the regime of effective field theories, such as hydrodynamics, where the dynamics are governed by the flow of conserved densities based on the symmetries of the system. However it is often hard to know what the boundaries of this regime are. This is even more true when a system is “quasi”-hydrodynamic meaning one of the conserved quantities, such as the number of particles, decays due to the presence of a “breaking parameter”.Gauge/gravity dualities are relationships from string theory that connect classical black holes to particular quantum theories that have the unusual property of rapidly becoming (quasi)hydrodynamic when perturbed. I seek to use gauge/gravity dualities to answer the following questions: When is quasihydrodynamics a good description of nature (in particular for large values of the breaking parameter)? For what ranges of parameters is it applicable? The first question can be explored by considering models of interdisciplinary relevance and searching for commonalities through which we can categorise them. To answer the second we can make use of the special properties of gauge/gravity theories - the existence of relationships between distinct models (dualities) to compute new results from old.The Marie Curie fellowship will allow me to strengthen my position as the intermediary between condensed matter and string theory, with this project as the initial bridging point. I will use the fellowship to increase my output in high impact journals (e.g. Physical Review Letters), apply for longer term grants and gain knowledge in a new area of physics