RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Guiding Light through Disorder in Adaptive Photonic Resonator Arrays' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Planar photonic crystals are dielectric nanostructures that are pursued worldwide as a platform for integrated nanophotonic circuits. Such circuits will process signals coded in light and will consist of thousands of basic components such as resonant nanocavities. At present, unavoidable nanometer-scale disorder makes such large-scale integration impossible. Disorder causes the resonances of the nanocavities to shift randomly, resulting in Anderson localization, an interference effect that blocks the propagation of light. Anderson localization – predicted in 1958 by Nobel Prize winner Philip Anderson – is an intriguing scientific phenomenon as well as a serious threat to applications.I propose to create adaptive nanophotonic systems. In these systems, I will use a spatially modulated light beam to modify the resonance frequency of each individual nanocavity. After adaptive tuning, the spatially structured light exactly counteracts the disorder and guides signals safely through the nanophotonic circuit. Effectively the signals will propagate in a perfect nanophotonic structure. As a second main innovation, I will employ an ultrafast structured light beam to write new, ordered and functional patterns into the circuit. This transformational technology will enable applications wherein optical circuits become fully programmable. The circuit will be modified dynamically in less time than that needed for a photon to pass through it. Spatial light modulators will enable us to address and control thousands of individual nanophotonic components.Our dynamic and adaptive nanophotonic system will enable new technology, such as dynamically tunable delay lines, and open up new regimes of light propagation: the crossover regime of Anderson localization, ultraslow light that propagates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating early pathogenic mechanisms of neurodegeneration in Parkinson's disease through a humanized dynamic in vitro model' (PD-HUMMODEL) targeting Seventh Framework.

assistant: **Abstract**

Our understanding of Parkinson’s disease (PD) pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic, most frequent, form of PD. It may be possible to overcome these challenges by reprogramming somatic cells from patients into induced pluripotent stem cells (iPSC). In preliminary studies, we have generated a collection of 50 iPSC lines representing both sporadic PD and familial PD patients, and identified distinct PD-related neurodegeneration phenotypes arising, upon long-term culture, in DAn differentiated from these PD-iPSC. Here, I propose to take advantage of this genuinely human PD model to investigate: i) mechanistic insights responsible for the PD phenotype identified in our model (by combining molecular and biochemical analyses to study mitochondrial function and redox profile, as well as genome-wide transcriptional profile of control versus PD-patient specific iPSC-derived DAn); ii) early functional alterations in patient-specific iPSC-derived DAn, which would predate neurodegeneration signs and provide valuable information as to ways to prevent, rather than rescue, neurodegeneration in PD patients (by electrophysiological recordings in in vitro reconstructed neuronal/glial networks to assess synaptic dynamics together with neuronal excitability); iii) further refinements in our iPSC-based PD model, including the generation of iPSC lines representing asymptomatic patients carrying pathogenic mutations, and the correction of known mutations by gene edition, all of which will allow exploring the relationship between pathogenic mutations and the genetic makeup of patients; and iv) whether DAn degeneration in PD is solely a cell-autonomous phenomenon, or whether it is influenced by an altere
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Towards a North-African Consortium of the Human Microbiome (NACHM) through  strengthening the Capacities in Microbiome Analysis for Human Diseases at University of Sfax', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

TheThe analysis of the human microbiome (genome of memberThe analysis of the human microbiome (genome of members of microbiota that is composed of billions of micro-organisms) is an emerging research area of considerable interest in human health and diseases. Disruption of the microbial community is a major risk factor for many diseases such as metabolic syndrome, immune disorders, cancer development, and is linked to limited response to treatment. In the last decade, numerous initiatives and projects were launched to take advantage of new, high-throughput technologies to characterize the human microbiome and to explore its relationship with health/diseases. Also concrete actions were engaged to provide a tangible response to the need to standardize and harmonize study methods and protocols, as well as regulations.Despite the increasing number of European and International initiatives on human microbiome, very few studies have been carried out in North Africa (NA). Therefore, there is an urgent need in NA for the development of skills in human microbiome analysis. With the support of the EU partners (Institut National de Recherche Agronomique (INRA)-Jouy en Josas and Aix Marseille University () from France and Florence University (UNIFI) from Italy), USFAX, aims to be a leading force in the region by: (i) increasing its staff capacities using new technological approaches such as Shotgun metagenome sequencing for the analysis of the human microbiome (ii) adopting a standardized approaches for collecting samples and analyzing data (iii) setting up and coordinating a consortium on human microbiomeat NA level building to start with on existing collaborations with Morocco, Algeria and Egypt that we have named “the North African Human Microbiome Consortium” (NAHMC). The MICAf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Privacy Protection and Auditing for Foundation Models' (Privacy4FMs) under Horizon Europe.

assistant: **Objectives**

Novel foundation models (FMs) like GPT, LLaMA, and Stable Diffusion are achieving exceptional performance across diverse tasks, generating high-quality text, images, and audio, and driving industry innovations. This progress stems from a shift in machine learning paradigm: instead of training task-specific models on curated datasets, FMs are first pretrained on vast, uncurated data to become strong general-purpose models, then adapted on smaller, domain-specific datasets for specific tasks.However, FMs leak information from their training data. For example, recent studies reveal that they can re-create individual data points from their pretraining and adaptation datasets. This poses serious privacy risks when private data is involved. Preventing exposure requires developing methods to ensure privacy-preservation throughout FMs' lifecycle, from pretraining to deployment. To achieve this, our project will identify sources of privacy leakage, provide privacy guarantees over both pretraining and adaptation, and audit FMs to detect privacy violations. Therefore, we must overcome three major challenges: the limited understanding of privacy risks in FM pretraining, the lack of formal joint privacy guarantees for pretraining and adaptation, and the ineffectiveness of current privacy auditing methods.The solution that we propose will establish a novel theoretical framework for privacy guarantees in FMs under the pretrain-adapt paradigm. Our fundamental innovations rely on the insight that, due to complex interdependencies between pretraining and adaptation data, different data points require individual levels of protection to prevent leakage. Advancing methods for identifying, achieving, and accounting for such individual guarantees will enable us to formally bound privacy leaka
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Climate Induced Changes on the Hydrology of Mediterranean Basins: Reducing Uncertainty and Quantifying Risk through an Integrated Monitoring and Modeling System' (CLIMB) targeting Seventh Framework.

assistant: **Abstract**

With regard to the objectives specified in ENV-2009.1.1.5.2, modeling capabilities must be improved and appropriate tools developed to advance the capability to assess climate effects on water resources and uses. The project consortium will employ a combination of novel field monitoring concepts, remote sensing techniques, integrated hydrologic (and biophysical) modeling and socioeconomic factor analyses to reduce existing uncertainties in climate change impact analysis and to create an integrated quantitative risk and vulnerability assessment tool. Together, these will provide the necessary information to design appropriate adaptive water resources management instruments and select suitable agricultural practices under climate change conditions. The integrated risk and vulnerability analysis tool will also enable assessment of risks for conflict-inducing actions, e.g. migration. The improved models, new assessment tools, and their results will be evaluated against current methodologies. Improvements will be communicated to stakeholders and decision makers in a transparent, easy-to-understand form, enabling them to utilize the new findings in regional water resource and agricultural management initiatives as well as in the design of mechanisms to reduce potential for conflict (linkage to SSH-2009.4.2.1).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Development of new AI-2 prodrugs and chemical probes to study the microbiota of the mammalian gastro-intestinal tract'.

assistant: **Innovation**

Quorum sensing allows bacteria to synchronise and regulate their behaviours. Autoinducer-2 (AI-2) is a particularly relevant signaling molecule able to promote inter-species communication. In the mammalian gut microbiota, a therapeutically relevant niche, interference of AI-2-mediated signaling has been shown to influence the balance of the major phyla after antibiotic treatment. Still, the mechanisms involved in this process are not known.  We propose to establish novel chemical and structural based approaches to decipher the mechanisms involved in the response of the gut microbiota to AI-2 and identify mechanisms that promote beneficial responses by the symbionts while inhibiting virulence in gut pathogens. For this, we will construct chemical tools that will function as AI-2 prodrugs to orally deliver intact AI-2 to the gut. AI-2 is a highly functionalised molecule, very reactive and unstable at high concentrations, thus a prodrug strategy will protect AI-2 until its release in the gut. To gain a molecular understanding involved in response to AI-2 we will identify AI-2 sensing mechanism (receptors) in commensal and pathogenic members of the microbiota belonging to the Clostridiaceae. For that, new AI-2 fluorescent probes will be designed and synthesised. The Clostridiaceae family are relevant members in the mammalian gut. These organisms include both beneficial as well as pathogenic members and we want to identify strategies to promote the beneficial response while inhibiting the pathogenic ones to promote a healthy microbiota community. Our hypothesis is that synthetic AI-2 can help in the recovery of a healthy bacterial phyla ratio after a distress, like antibiotic treatment.


**Keywords:** Quorum sensing, AI-2, prodrugs, carbohydrate chemistry, fluorescent probe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Development of high sensitivity, wide dynamic range, mechanoelectrical transducer integrating artificial hair cell with artificial neurons'.

assistant: **Innovation**

The human ear distinguishes sounds with astonishing sensitivity. It is able to resolve frequencies differing by 0.2% over 130 decibels of intensity. To achieve this feat the ear combines different strategies which we will implement in sensors of unprecedented sensitivity. The ear uses the power of Brownian noise in the cochlear fluid to enhance the detection of weak periodic signals. Each frequency is analyzed by specialized auditory hair cells which have different lengths and use a property called negative stiffness to enhance detection sensitivity. The incoming fellow has recently proposed a theoretical scheme for amplification by negative stiffness which he has demonstrated using a bench top experiment. Through a series of recent papers, the host group has conceived and studied a biomimetic neuron which sums and thresholds electrical pulses. In particular, the neuron demonstrates the amplification of useful signals by random noise using a property known as stochastic resonance. The present project will integrate artificial hair cells with semiconductor neurons to deliver highly sensitive, low power, scalable mechano-electrical transducers. We will study the amplification properties of the hair-neuron system. We will then integrate artificial hairs on neurons to make an artificial cochlea of microscopic size. We will fabricate hairs of different length/diameter aspect ratio to detect specific audio frequencies and code the sound intensity in the firing rate of the neuron. This fellowship will thus prepare the next generation of hearing aids, hydrophones and voice recognition systems by incorporating advances in non-linear physics and nanoscience in our cochlear sensor. The sensor will improve the range of sub-marine detection and lead to smarter, smaller hearing aids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neural & Computational Principles of Multisensory Integration during Active Sensing and Decision-Making' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Perceptual decisions rely on the integration of information from the environment, which typically involves the combination of stimuli from different senses. The quality of sensory evidence depends highly on our actions that affect how we acquire information from the external world. Importantly, the processing of this multisensory information requires the interaction of multiple neural processes over time. However, the neural mechanisms underlying this complex human behaviour remain elusive. In this project, I will employ a novel active sensing paradigm coupled with state-of-the-art neuroimaging and computational modelling to probe how the brain samples, processes and integrates multisensory information in order to make fast and accurate decisions. I will devise a reaction-time task where human subjects will actively sense and discriminate the amplitude of two texture stimuli a) using only visual information, b) using only haptic information and c) combining the two sensory cues, while electroencephalograms (EEG) will be recorded. To study this, I will develop a novel computational methodology for the joint analysis of brain activity (EEG), sensorimotor signals (movement kinematics) and behavioural measurements (choice and response time). First, behavioural modelling will provide a mechanistic account of the constituent processes underlying decision fomation. Then, model predictions will inform the joint analysis of neural and sensorimotor signals, to characterize the neural and behavioural basis of active multi-sensing and decision-making. To achieve this, I will devise an information-theoretic methodology that quantifies a) the contribution of each sensory modality to perception and b) the interaction of their neural representations to drive perceptual decisions. Ultim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advancing Civil-Military Interoperability and Coordination through Excellence in Science and Technology' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The ATM-EXCITE project will identify the requirements of ATM systems for civil-military aviation coordination and cybersecurity and develop a set of solutions. The project will engage with stakeholders throughout the solution development phase to ensure that the proposed solutions meet their needs.By engaging with stakeholders and using a rigorous approach to solution development, the project team is confident that it will develop effective and implementable solutions to the challenges of civil-military aviation coordination and cybersecurity. Once the requirements have been identified, the project team will design, develop, and test proposed solutions using a variety of approaches, including system design, software development, and cybersecurity testing. The project team will design system architectures for the proposed solutions. The system architectures will take into account the requirements of ATM systems, cybersecurity best practices, and operational constraints.The SESAR ER call explicitly emphasizes the need for enhanced security, confidentiality, and anonymisation in the realm of military aviation data. The call also draws attention to the vulnerabilities associated with real-time airborne position data. Our proposed solutions aim to directly address these vulnerabilities by introducing methods for verification of ADS-B data and selective encryption and model the interaction between civil and military systems in an efficient manner.This strategic alignment ensures that the solutions directly impact the priorities outlined in the European ATM Master Plan, further promoting the harmonisation of civil and military aviation in the European sky. Within the work areas of improved security of military operations and digitalisation for Airspace Management (ASM) and mis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'HealthyCloud – Health Research & Innovation Cloud', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The creation of a European Health Data Space is one of the six strategic priorities for the newly elected European Commission. The European Health Research and Innovation Cloud (HRIC) will be one of the future cornerstone pieces for this area. HealthyCloud will deliver a Strategic Agenda including a Ready-to-implement Roadmap for the HRIC ecosystem. The Strategic Agenda will incorporate the consolidated feedback of a broad range of stakeholders: the European Commission, the Member States and regional, national, European and international relevant initiatives. These agents will be invited to be part of the HealthyCloud’s Stakeholders’ Forum, designed to facilitate the dialogue among them and the Consortium, and to act as an umbrella to bring together similar efforts in specific domains.HealthyCloud has been organized around four fundamental objectives that cover 1) interactions with stakeholders to ensure their voices are included as part of the Strategic Agenda; 2) the inclusion of Ethical, Legal and Societal aspects in the design of the future HRIC ecosystem; 3) the sustainable access, use and re-use of health-related data considering a progressive adoption of the FAIR principles; and 4) the technological solutions in terms of computational facilities and mechanisms to enable distributed health data analysis across Europe. The project is driven by two real-world use-cases (Cancer and Atrial Fibrillation) to ensure that propositions by domain-specific and technological experts are technically and ethically sound and legally compliant. The ultimate goal is to propose an ecosystem that builds and reinforces the trust of patients and citizens in the use of their health data for research.HealthyCloud is a 30-month project that brings together 21 organizations with broad and