RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy' in the context of a Horizon 2020 call.

assistant: **Objectives**

Osteoarthritis (OA) is the most widespread joint disease, affecting millions and imposing a huge individual and socio-economic burden.  The creation of liposomes functionalised with novel (IP-protected) molecules that greatly extend (by almost an order of magnitude) their half-life in joints following IA injection, relative to existing approaches, and the alleviation of OA that may arise through exploiting this longer retention, is the basis of this proof of concept project. The main innovation step is functionalizing liposomes with our novel molecules to provide much longer retention drug-delivery vehicles, which therefore provide greater benefits in therapy relative to existing approaches, and so should be preferred by patients. Its practical implementation, to advance and investigate the potential for long-retention IA drug-delivery and other uses, will be carried out both through validation on animals (proof-of-concept), through suitable pre-commercialisation studies, networking and identifying potential partners, and developing a business plan. Hence, we propose to validate the concept of creating new products that will be available commercially for IA delivery, implementing the long-retention in the joints which greatly enhances their usefulness and which is the basis of the present innovation step.


**Keywords:** Liposomic drug-delivery vehicles,  intra-articular injection,  retention-time
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Financing Entrepreneurial Ventures in Europe : Impact on innovation, employment growth, and competitiveness'.

assistant: **Concept**

The aim of the VICO project is to assess the impact of Venture Capital and Private Equity (VC/PE) financing on the economic performance of European innovative entrepreneurial ventures as they are reflected by their innovation output, employment, growth, and competitiveness, and the role VC/PE investors play in helping these firms bridge their resource and competence gap beyond the provision of financing. Particular attention will be devoted to the institutional variety of VC/PE investors in Europe. We will consider factors affecting both the demand for and the supply of VC/PE financing, at micro and macro level. In particular, we will  analyze how the effects of VC/PE financing on the economic performance of portfolio companies are moderated by i) the characteristics of the investor, ii) the characteristics of invested firms, and iii) the characteristics of the business and institutional environment in which firms operate. In addition, we will examine specific open issues that play a crucial role for the development of the VC/PE sector in Europe, namely: i) the design of a mix of multi-level policy schemes targeting seed and pre-seed capital; ii) exit mechanisms for VC/PE investors; and iii) the European integration of the VC/PE sector and the internationalization of VC/PE investors. The project will benefit from a unique combination of qualitative (survey analyses and case studies) and quantitative empirical methodologies. As to these latter, the project will build and use a micro&macro cross-country panel type dataset with a rather long longitudinal dimension and wide coverage of EU countries so as to overcome some of the key weaknesses of the extant empirical literature.  The consortium is a blend of well known scientists from different disciplines (i.e. finance, inn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A NOVEL BIOPROCESS COUPLING WASTEWATER TREATMENT WITH ELECTRICITY PRODUCTION TO REMEDIATE METAL POLLUTED AQUATIC ENVIRONMENTS' (SEFCUMPAQ) under Seventh Framework.

assistant: **Objectives**

Worldwide contamination of the aquatic environment with heavy metals (such as Fe, Co, Ni, Se, Zn, Pb, and Ni) and organic compounds has become a major concern, disturbing the natural functions of rivers/lakes and ponds, causing ecological and health problems. The microbial fuel cell (MFC) is a special form of a fuel cell in which bacteria catalyze the oxidation of organics and produces electricity. MFCs could provide an elegant novel ecotechnology, combining the clean-up of the pollutants (organic matter, metals or sulfate) with electricity production. This IEF will study a particular form of MFCs, that can easily be integrated in natural treatment systems: sediment fuel cells (SFCs). SFCs rely on the natural voltage gradient between the sediments and the overlying seawater. This gradient is created by microbial oxidation of subfloor organics, which results in the generation of electron-rich reductants such as Fe2+ or HS-. However, SFCs are still facing a challenge for consistent power production over extended periods. The composition, mechanisms involved in electroactive biofilms remained largely unknown and the potential of SFCs for metal polluted aquatic environments (MPAE) have not been explored yet. This IEF will develop a novel SFC, which will be tested on MPAEs, both polluted natural fresh and sea water. Thus, this IEF will contribute to the development of a cost effective alternative to current fuel utilization. The novel SFC will be evaluated as a function of organics/metals turnover and specific power production rates and in parallel, novel analytical techniques/methods to enhance/measure the biofilm activity (electrochemical). Finally, a prototype will be tested. This IEF will provide a tool and an instrumental role for water frame work Directive 2000/60/EC o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cell-type specific mechanisms regulating rhythms in leukocyte homing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Leukocytes are the key components of the immune system that fight infections and provide tissue repair, yet their migration patterns throughout the body over the course of a day are completely unknown. Circadian, ~24 hour rhythms are emerging as important novel regulators of immune cell migration and function, which impacts inflammatory diseases such as myocardial infarction and sepsis. Altering leukocyte tissue infiltration and activation at the proper times provides an option for therapy that would maximize the clinical impact of drugs and vaccinations and minimize side effects. We aim to create a four-dimensional map of leukocyte migration to organs in time and space and investigate with epigenetics techniques the molecular mechanisms that regulate cell-type specific rhythms. We will functionally define the daily oscillating molecular signature(s) of leukocytes and endothelial cells with novel proteomics approaches and thus identify a circadian traffic code that dictates the rhythmic migration of leukocyte subsets to specific organs under steady-state and inflammatory conditions with pharmacological and genetic tools. We will assess the impact of lineage-specific arrhythmicities on immune homeostasis and leukocyte trafficking using an innovative combination of novel genetic tools. Based on these data we will create a model predicting circadian leukocyte migration to tissues. The project combines the disciplines of immunology and chronobiology by obtaining unprecedented information in time and space of circadian leukocyte trafficking and investigating how immune-cell specific oscillations are generated at the molecular level, which is of broad impact for both fields. Our extensive experience in the rhythmic control of the immune system makes us well poised to characte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Assessment of vehicle-track interaction with special reference to DYnamic SAFety in operating conditions'.

assistant: **Innovation**

Objectives and content Train and Track dynamic interaction is a key issue of Railways operation. The forces generated at the interface between wheel and rail determine the conditions of a safe operation of trains, with regard especially to derailment and track resistance, and of a good ride quality, i.e. a high level of comfort. Safety criteria and limits are defined, allowing to guarantee that no dangerous conditions can be met in operation conditions. Three dynamic safety criteria are at stake: the derailment, the track lateral resistance and the overturning conditions. But these limits are based on the results of scientific investigation performed in the early 70s, mainly at low speed, and the dynamic interaction effects are not well enough understood and quantified with regard to the present requirements of railways. The increase of commercial speed, the development of technologies aimed at fully exploiting the capacity of the railways system, such as tilting trains, indeed require a better understanding of this interaction, with consideration of the whole range of dynamic efforts at stake in safety and comfort. As the safety margin included in criteria is not known very accurately, it is probably often larger than really necessary, and is a limiting factor, hindering the full exploitation of the infrastructure. There also exists a lack in measurement techniques to characterise the dynamic interaction between a vehicle and the infrastructure. Such techniques are of course available to investigate the behaviour of prototypes, but they are difficult to use and costly. In front of the requirements of vehicle development and certification, and of interoperability rules, these techniques are far from being efficient and cost-effective enough. DYSAF intends to bring a dec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Co-funding of International Fellowships in Cancer Research' in the context of a Seventh Framework call.

assistant: **Objectives**

The Italian Association for Cancer Research (AIRC), the Italian leading charity providing about 40% of all research funds invested in cancer research in Italy, proposes to award 60 fellowship-years for international mobility in two yearly calls for proposals. The calls will be published, executed, and concluded in the 4 years of the FELCARES duration. AIRC aims at increasing its international dimension by strengthening its current programme of Outgoing Fellowships and by introducing the new tool of Incoming and Re-integration Fellowships. To reach this goal, AIRC will: a)Increase the number of the international fellowship-year from 12 awarded in 2008 to 30 per year to be awarded in FELCARES; b)Increase its own budget committed per year; c)Increase the fellowship’ wages from the current average 30.279 Euro/year to an average 40.000 Euro/year. AIRC will take advantage of its well-established and transparent criteria and methods for the evaluation and selection of the applications, adapting them to the new proposed international dimension. In the new international calls, AIRC will address the following issues: Multidisciplinary and multisectorial approaches to cancer research;Attention to researchers from less-favoured countries in Europe and worldwide;Complementary skills training in the projects to be awarded;Special care to achieving the optimal gender balance in cancer research.The anticipated outcomes of the proposed international fellowship programme will coincide with the main objectives of ERA. Bringing its initiatives to a wider international level, AIRC will expand its worldwide contacts and will get in touch with other similar programmes in Europe. This will contribute to overcome the fragmentation of the many programmes that are currently implemented in a dispe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Genetic basis of emergent social behaviour from genotype-phenotype mapping'.

assistant: **Concept**

Social behaviour plays an important role in the survival and development of many species with the most conspicuous and ubiquitous form being collective behaviour – the coordinated action of two or more individuals of the same species. Despite immense interest in collective behaviour in biology, the dynamic relationship between genotypes and phenotypes characterising this phenomenon remains opaque. Understanding this link, however, is crucial to elucidating the mechanisms of collective behaviour and emergence of social structures, and, most importantly, the genetic origins of social behaviour. In this project, I aim to quantify the genotype-phenotype mapping in the social behaviour of the nematode worm Caenorhabditis elegans using quantitative phenotyping and computational modelling. Due to its unique amenability to exhaustive genetic analyses, trackability and rich collective properties (so-called collective feeding), C. elegans is a perfect system to address this question. My project will use high-throughput imaging data of social feeding in hundreds of different C. elegans strains. I will develop a novel dynamic multi-state model based on worm postures and spatial positions, allowing to quantitatively describe nematode social behaviour in a worm density-dependent manner. My research programme will, for the first time, rigorously examine the phenotypic behavioural space in C. elegans and test its tolerance to mutations in a social context, hereby providing insights into the genetic basis of emergent social behaviour. Such a study is extremely timely as it will build on the brand-new nematode data collected at my host university using cutting-edge imaging and tracking techniques. This interdisciplinary project will provide significant amounts of training in modern quant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'THz Muti-Gb/s System in Package' (TMGSiP).

assistant: **Innovation**

The goal of ""THz Muti-Gb/s System in Package"", i.e., ""TMGSiP"" project is to develop a fully integrated 120GHz radio front-end for Multi-Gb/s radio links with state-of-the-art SiGe BiCMOS technology. This will be done with a completely new cross-cutting design methodology for silicon-MMIC, e.g. the development of wideband receiver and transmitter, including on-chip antenna and novel packaging concepts. This will enable a big improvement in the functionality (complexity of RF MMICs), performance (data rate), component size (fully-integrated compact MMIC with integrated antennas), low power, and cost over existing III/V communication systems.The project’s ambition is to realize a THz SiP analog front-end with integrated antennas for a line of sight communication link with data rates up to 40Gbps centered around 120GHz and bandwidth of 20GHz with range up to a few meters. Due to the huge available bandwidth only simple low-order modulation schemes like QPSK will be considered.""


**Keywords:** 120GHz Wideband transceiver, Wide band antenna, sub-THz package, Terahertz-communication
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reconstruction using Scanned Laser and Video' in the context of a Fourth Framework call.

assistant: **Objectives**

The purpose of RESOLV is to produce a cost-effective system for creating realistic 3D models of the environment. These will enhance the sense of 'being there' for telepresence and virtual reality applications. The models will also be sufficiently accurate for real estate, construction and other industrial applications.Following completion of the Requirements and Specification reports, the prototype EST trolley has been assembled. The spatial reconstruction and texture algorithms have been integrated to produce textured scenes such as those shown here. The software has been transferred from the workstation development environment to the PC in the EST so that reconstruction can take place during the capture process.The navigation and registration algorithms for the Autonomous EST have been tested and these were demonstrated in early 1997. A high speed laser scanner has been evaluated and will be included in the Autonomous EST.Expected Achievements The output from the project will be a set of algorithms for producing 3D reconstructions of intended environments requiring the fusion of range data and texture information from many capture points.These algorithms will be implemented in two types of environmental capture device, one portable and the other autonomous. Technical results will include an assessment of which applications suit the RESOLV approach of integrating laser scanning with digital images.An assessment will be made of the nature of the markets for the overall methodology and a suitable exploitation path will be identified in the light of user responses to the interiors and telepresence trials.Expected Impact RESOLV is expected to be one of many catalysts in encouraging a universal move to more natural three dimensional user interfaces. The most obvious demand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Image-guided Diagnostics and Therapy - Novelty, Internationality and Excellence' (IGNIDTE).

assistant: **Concept**

The MSCA COFUND action IGNIDTE will foster a new generation of twelve excellent researchers through training at the interface of clinical medicine and basic science in medical imaging and image guided therapies at the Medical University of Innsbruck (MUI) and the University of Innsbruck (UIBK). Home to one of the largest hospitals in Austria and a world-renowned array of researchers in clinical sciences, biomedical engineering and medical physics, MUI provides a unique breeding ground for multidisciplinary research and training. Closely entangled with MUI and a world-leader in multiple research areas of physics, applied mathematics and engineering, UIBK will complement the biomedical expertise of MUI. With the mission to be next in excellence, IGNIDTE will build upon the doctoral program “Image Guided Diagnostics &Therapy” (IGDT) jointly established and partly funded by the national science fund (FWF) from 2020-2025 at MUI and UIBK and expand on it with a focus on Novelty, Internationality, and Excellence.Novelty: By opening new grounds in the training program, enhancing access to complementary expertise in clinical medicine and biomedical technology, educating on aspects beyond the typical research tasks in PhD projects (project management, social skills and innovation). Additionally, the faculty will be enlarged in gender equality, by including young faculty members, new specializations (neuropathology) and scientists with dual education (medicine and physics).Internationality: Beyond the recruitment process and conference visits, each doctoral candidate will be offered secondments at academic and/or non-academic partner institutions in Europe. Excellence: Providing excellent, interdisciplinary supervisory teams comprising medical and basic scientists, excellent manag