RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A General Strategy for the Generation and Use of Oxygen Centered Radicals in Organic Synthesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Oxygen-containing molecules are widespread as medicines, agrochemicals, organic materials, perfumes and dyes. Their preparation could be greatly facilitated by implementing oxygen-radicals, which are a class of very versatile synthetic intermediates. However, to date, difficulties associated to their generation have severely limited their use and exploitation in synthetic settings. Here we propose the development of two conceptually novel and general ways to prepare oxygen-radicals using visible-light. These processes will capitalize on recent developments in the host group that has disclosed two novel organocatalytic ways for the generation of nitrogen-radicals. This proposal seeks to substantially expand this photochemical approach by developing unprecedented methods for the generation and use of oxygen-radical. The power of this approach will be demonstrated by fast generation of 3D molecules containing multiple atoms of oxygen. These methods will be then integrated with other reaction platforms that, taking advantage of visible-light as source of energy, will engage the oxygen-radical in new reactivity modes, to allow novel and powerful multicomponent oxo-functionalization reactions. Furthermore, we will harness this activation modes to enable the direct oxygenation of aromatic compounds in a single step without the use of transition metal catalysts.Through the use of this strategy, the rapid construction of many relevant and complex oxygenated molecules will be possible. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Photonic Integrated Circuits using Crystal Optics' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The explosive growth of the Internet has led to unprecedented bandwidth requirements in the telecommunications network. As a result, there is a need for new advanced technologies that can enable the high-speed processing of this exponentially growing data traffic. PICCO proposes high contrast photonic microstructures on a wavelength scale as a novel technology that will recast our notion of waveguide integrated optics and lead to truly high density integrated circuits in Photonics. PICCO will demonstrate ultracompact, wavelength selective and wavelength converting elements and underpin their design by sophisticated CAD tools. We will study photonic crystal/photonic wire based components such as straight waveguides, bends, couplers and splitters and establish the most suitable material system (GaAs or SOI) to implement these. We will also develop a novel monolithic wavelength converter based on these generic components. Finally, PICCO will assess the feasibility of fabricating these devices by deep UV lithography, thereby offering a route to mass-manufacturing highly complex yet low-cost opto-electronic components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microbial population control in biofilm reactors for sustainable nitrogen removal from wastewater' (POPCON4BIOFILMS).

assistant: **Innovation**

In the search of improving the sustainability of nitrogen removal from wastewater, techniques that convert ammonium to nitrite only (i.e., the so-called nitritation reaction) and prevent further oxidation of nitrite to nitrate, have been denoted for quite a while as very promising. The nitritation step forms the key part of innovative sustainable nitrogen removal processes, that result in lower oxygen energy requirements, less or no need for external carbon dosage, at the same time minimizing sludge product ion and CO2 emissions, compared to conventional nitrification-denitrification over nitrate. For this reason, this project will focus on the nitritation reaction and more specifically, on establishing stable nitrite formation in a stable and sustainable way, not only in the short term but also over long time periods.Different possible control approaches for the nitritation step will be investigated. Because of their distinct advantages, biofilm reactors have been selected for the development and implementation of control strategies. Although the application of control strategies for sustainable N-removal processes in biofilm reactors is a largely unexplored area, it will become very soon a key issue as biofilm applications are gaining more and more attention from the scientific community and the industry. But the main innovative nature of the project lies in the addition of microbial population optimisation as a new aspect to the control of the nitrogen removal processes under study.In this way short-sighed optimisation that may have an adverse effect in the long term is avoided. Instead, the control objective consists of population dynamics management, maintaining microbial diversity to ensure a robust process on the long term. To reach this goal, a biofilm reactor m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'First ever preventive treatment for celiac disease and gluten sensitivity' (E40) targeting Horizon Europe.

assistant: **Abstract**

E40 is a novel gluten degrading enzyme aimed at enhancing the degradation of ingested gluten, particularly in gluten intolerant Celiac Disease (CeD) and Non-Celiac Gluten Sensitivity (NCGS) sufferers.Different from any other competing enzymes under development, E40 efficiently exerts its gluten degrading activity in both the stomach and the intestine of CeD and NCGS sufferers, supporting the benefits of a Gluten Free Diet (GFD). The final goal is to prevent symptomatology due to the pro-inflammatory reaction triggered by gluten.E40 will allow sufferers to manage inadvertent gluten exposure and will improve sufferer's Quality of Life, in particular allowing them to normalise their work and social life, reducing anxiety and allowing them to enjoy many everyday activities, like eating in a restaurant, travelling and visiting their friends in their homes.E40 is produced by an engineered, patented acidic Streptomyces lividans TK24 strain, and directly purified in its mature, functional form. E40 activity has already been confirmed using the validated human simulated digestion INFOGEST assay of real food digestion: E40 gluten degradation leads to a gluten-free status (residual gluten<20ppm as per EC guidelines).


**Keywords:** Glutenase,Preventive treatment,Gluten intolerance,Celiac disease
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European phenological network - a network for increasing efficiency, added value and use of phenological monitoring, research, and data in europe (EPN)' (EPN) under Fifth Framework.

assistant: **Objectives**

EPN aims to improve monitoring, assessment and prediction of climate induced phonological changes and their effects in Europe. The network will increase the efficiency, use, and added value of phonological research, monitoring, and data management in Europe. Changes in phonological events will have a wide range of consequences for ecology, agriculture, and human health. To cover the many scientific and policy aspects, both researchers and relevant end-users are involved. Through the organisation of two European conferences and six specialists workshops, the network enhances the coherence and collaboration in phonological research and monitoring in Europe, and thereby improves the exploitation and synthesis of existing data. By developing a comprehensive structure for data collection, management and dissemination, EPN will also enhance the application of phonological information by many end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MOlecular-Scale Biophysics Research Infrastructure' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of the MOlecular-Scale Biophysics Research Infrastructure (MOSBRI) is to enable ambitious integrative multi-technological studies of biological systems at the crucial intermediate level between atomic-resolution structural descriptions and cellular-scale observations.Its consortium of 2 companies and 13 academic centres of excellence from 11 countries gathers a wide complementary panel of cutting-edge instrumentation and expertise, leveraging barriers that currently hinder the optimal exploitation of molecular-scale biophysical approaches in the fields of biomedicine, biotechnology, biomaterials and beyond.MOSBRI provides European academic and industrial researchers with a one-stop shop Trans-National Access to the latest technological developments in advanced spectroscopies, hydrodynamics, thermodynamics, real-time kinetics and single molecule approaches. It will play a major role in standardization and policy-making in the field by: i) carrying out Joint Research Activities to develop innovative methodologies; ii) designing robust quality control guidelines and FAIR-compatible archiving formats and databases; iii) engaging with instrumentation, pharma, biotech and CRO SMEs. Networking activities will multiply the impact of MOSBRI, by efficiently sharing and disseminating theoretical and practical knowledge through training events in Europe, contributing to: i) the emergence of a highly qualified new generation of scientists; ii) outreach to scientific communities currently unaware of the full potential of the integrated use of molecular-scale biophysics tools.MOSBRI is complementary to related infrastructures including INSTRUCT-ERIC and iNEXT-Discovery, and will help creating a strong cross-fertilizing ecosystem with leveraging effects for European science. It
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Tundra degradation in the Russian Arctic' (TUNDRA) targeting Fourth Framework.

assistant: **Abstract**

TUNDRA (TUNdra Degradation in the Russian Arctic) is a multi-disciplinary research project that studies global change in the Russian Arctic. It consists of a West-European component (this proposal) and a Russian component (summary only). The West-European component, planned over three years (proposed starting date is January 1998), will assess possible feedbacks from the Russian Arctic to the global climate system through changes in greenhouse gas emissions and in freshwater input to the Arctic Ocean. This component has a clear 'European Dimension' since feedback processes originating in the Russian Arctic might affect the concentration of greenhouse gases in the atmosphere and the strength of the northern branches of the Atlantic Gulf Stream, with direct repercussions for the climate in WestEurope. The Russian component is planned as a series of INTAS (or other) proposals, with a duration of up to two years, that will address research issues in the Russian Arctic which have a more regional dimension. What follows is a short description of the West-European component of TUNDRA. The area selected for TUNDRA studies, the Usa Basin in the East-European Russian Arctic, includes major ecotones (e.g. Arctic and alpine treelines, southern limits of discontinuous and continuous permafrost) and industrial pollution gradients (especially from oil, gas and coal exploitation). Individual research groups of the project will study 1 ) climate change and the carbon cycle, 2) climate change and the hydrological cycle, and 3) industrial pollution and social awareness. The latter group will assess how pollution might affect ecosystem function, and how human attitudes could change environmental legislation and its implementation. Research groups will develop base-case scenarios that inclu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Phase-locked harmonic gyrotrons for scientific and technological applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The proposed project aims to answer the question whether it is feasible to phase-lock a harmonic gyrotron oscillator by estimating the input power needed for such an operation and studying the influence of a number of parameters on the locking conditions. Since available microwave sources, which can be used to provide the input (locking) signal, are limited in frequency and power, it is proposed to premodulate the electron beam in an input cavity at the fundamental of the gyrofrequency and to use the harmonics of the ac beam current to lock the output of a second cavity at the harmonics of the gyrofrequency. This will reduce considerably the required frequency of the input signal and will facilitate the choice of the source to provide it. The design of a third harmonic gyrotron will be given and a general theory for phase-locking a harmonic gyrotron oscillator via a premodulated electron beam will be developed. Competition from other harmonics and especially from the fundamental component of the ac beam current will be considered. A small-signal theory will be developed to study the influence of peniotron interaction on harmonic gyrotron operation. Spread in electron velocity and guiding center will be included. A preliminary design of a phase-locked harmonic gyrotron will be attempted to illustrate the results of the developed theory and to study the feasibility of this kind of microwave tube.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Spectroscopy of exotic nuclei in a Magnetic Active Target', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

SpecMAT aims at providing crucial experimental information to answer key questions about the structure of atomic nuclei:- What are the forces driving the shell structure in nuclei and how do they change in nuclei far from stability?- What remains of the Z = 28 and N = 50 “magic numbers” in 78Ni?- Do we understand shape coexistence in nuclei, and what are the mechanisms controlling its appearance?The position of natural and “intruder” shells will be mapped in two critical regions, the neutron-rich nuclei around Z = 28 and the neutron-deficient nuclei around Z = 82. The centroids of the shell strength are derived from the complete spectroscopy of those systems in nucleon-transfer measurements. This method will be applied for the first time in the region of neutron-deficient Pb nuclei.In SpecMAT (Spectroscopy of exotic nuclei in a Magnetic Active Target) a novel instrument will overcome the present challenges in performing such measurements with very weak beams of unstable nuclei. It combines high luminosity, high efficiency and a very large dynamic range and allows detection of both charged-particle and gamma-ray radiation. The instrument owns its remarkable performances to a number of advanced technologies concerning the use of electronics, gaseous detectors and gamma-ray detectors in a magnetic field.The SpecMAT detector will be coupled to the HIE-ISOLDE facility for the production and post-acceleration of radioactive ion beams in construction at CERN in Geneva. HIE-ISOLDE will provide world-unique beams thanks to the use of the proton injector of the CERN complex.If successful, SpecMAT at HIE-ISOLDE will produce specific results in nuclear structure which cannot be reached by other programmes elsewhere. Such results will have a significant impact on the present theorie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Proteomic analysis of micro-dissected neurons from huntington disease brains.' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Striate and cortical neurons from Huntington Disease (HD) and normal control brains will be selectively captured using laser capture micro dissection. Proteins extracted from these cells will be analysed using a range of polemic techniques. Biomarkers of HD represent potential targets for therapeutic intervention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'THE GENERATION OF CD8 T CELL MEMORY' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

CD8+ T cells are fundamental targets for improved vaccination strategies, since they are fundamental to virus and tumors control, and current immunization protocols to generate efficient CD8+ responses are essentially inadequate. Major handicaps are the l ack of correlation between the current tests used to study CD8+ T cell function and infection out-come or efficient memory generation. The present project will study responses and memory using new methodological advancements that should allow efficient cha racterization of CD8+ differentiation programs. Functional profiles will be defined using a new methodology developed in the host laboratory, that allows the simultaneous quantification of 20 relevant gene products expression in each individual antigen-spe cific CD8+ T cell ex-vivo. We will study the impact of different immunization protocols, studying the same clone of T cell receptor (TCR) transgenic (Tg) cells responding to the same antigen presented in different forms, i.e., cells expressing naturally th e antigen, mature and immature dendritic cells loaded ¿in vitro¿ with peptide or recombinant Listeria expressing the same antigen. To evaluate the impact of TCR affinity, we will also study the responses to the same immunization protocol of different T cel l clones, covering a large range of TCR affinities. Finally we will evaluate the role of IL-7R in memory T cell generation. We developed IL-7R Tg mice that cannot down regulate IL7R during immune responses. IL-7R expression is essential for peripheral T ce ll survival, but the reason for its down-regulation upon T cell activation and the mode of its re-expression in memory T cells is obscure. The study of immune responses in these Tg mice will provide definitive answers on the role IL-7R expression in CD8+ m em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The European Legislative Virtual Library' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

ELVIL will develop an Internet-based aid for search, selection and presentation of information on European law and politics. Today this body of information is scattered among numerous locations and media with no unified method of access. The application will significantly increase the availability of the information and be an important step towards building a European infrastructure of legal and political information to the benefit of both the civic and educational community.The intended users consists of graduate and undergraduate students, teachers, librarians, media and the general public. The application increases the availability of information by supplying a point-and-click graphical interface to a wide range of legislative computer based resources. It will contribute to the development of new multimedia teaching tools and services and will facilitate distance-learning.Technical approachThe project consists of three parts - a pedagogical and easy-to-use interface, a WWW-index and a search engine - which form an integrated whole: The European Legislative Virtual Library (ELVIL).The first part will assemble a WWW index on law and politics in Europe in order to gather all Internet-accessible computer-based information resources on European law and politics into one coherent WWW-accessible database. A final prototype will be presented after 20 months.The second part will develop a multimedia educational aid, including a multi-lingual thesaurus, for students of European law and politics, teachers and librarians. A final prototype will be presented after 24 months.The third part will construct a search engine composed of a common WWW interface and software gateways for easy and concurrent access to the national parliamentary databases and to the European parliamentary d