RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Numerical simulations of particle-laden turbulent channel flows'.

assistant: **Concept**

Turbulent flow fields laden with small particles much heavier than the gas phase occur in a wide range of natural and industrial processes such as pollutant dispersion in atmosphere, fuel injection into engine, piping in chemical engineering... The interactions between the particle and the turbulent flow imply a lot of interdependent effects, many of which remain poorly understood. The development of good engineering models using is therefore challenging. A long-term research project is going on at Kramer Laboratory, on the improvement of Eulerian models using direct and large-eddy numerical simulations (DNS and LES) of simple flows. This one- year project will be inserted into this lager project. The major objectives of this project are: gain a better understanding of the mechanisms associated with particle-turbulence interactions in a two-phase channel flow, and provide subsidies on how to model these effects in the context of Eulerian simulations. The project will consist of three stages:-Adaptation of the existing code, to perform energy balance and spectra-Simulations with different particle-loading and analysis of the results.- Implications for two-fluid models. Some attempts will be made to provide ideas on how to model two-way coupling effects in terms of interactions involving multiple turbulence-scales (say, large and small scales ).Training content is based on both two-phase flows physics and numerical simulations. My PhD studies have brought me to reflect on particles effects on turbulent flows. The research project proposed at Kramers Laboratory will allow me to make the most of my knowledge of two-phase flows physics and complete my scientific training on that point. Till now, my competence is essentially based on experiments, this work will offer me the o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Plant Immune System: Epistasis and Fitness-Tradeoffs' under Seventh Framework.

assistant: **Concept**

A fundamental question in biology is how multicellular organisms distinguish self and non-self. The requirement to specifically recognize only foreign cells and molecules constrains the diversification of the immune system, resulting in conflicts between effective detection of enemies, adaptive changes in the cellular machinery and mating with divergent genotypes from the same species. In plants, there is generally a trade-off between immunity and growth, and immune system activation is often associated with impaired development. There are many examples of autoimmunity in hybrids, caused by a gene product from one parent erroneously interpreting a gene product from the other parent as foreign. This is not surprising, given the extraordinary diversity of many immune genes. On the other hand, hybrid vigor, or heterosis, is commonly observed in F1 progeny from two inbred parents, and this is widely exploited in breeding. Thus, it is also of practical importance to understand how outcrossing affects the plant immune system. We hypothesize that overt hybrid autoimmunity represents only the tip of the iceberg, and that there are many more subtle non-additive genetic interactions that affect both the plant immune system and growth. We therefore propose a comprehensive research program to dissect epistatic interactions with effects on plant growth and health. Specifically, we will conduct genomics-enabled, systematic forward genetic studies with natural genotypes of the model plant Arabidopsis thaliana and its outcrossing sister species A. lyrata. This will be complemented by experiments that will link diversity of microbial communities with that of the immune system in natural plant populations. The systematic understanding of forces that shape the distribution of immune gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New geometries and mathematical tools from and for string theory' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The symbiotic relation between string theory and mathematics has proven to be a gold mine for both fields, providing a guideline for the mathematicians and powerful tools for the physicists.For example, by extending the newly discovered mathematical concept called generalized complex geometry (GCG) to the supersymmetric sigma model, a new understanding of the mathematics of extended supersymmetric sigma models is being achieved.On the other hand, generalized complex manifolds have been shown to arise in the context of string theory compactification with fluxes and a better knowledge of the underlying mathematics will lead to powerful tools for the physicists to apply.The discovery that non-commutative manifolds naturally emerge in the context of string theory led to a burst of activity in the field and to new insight into string dynamics from the study of non(anti)commutative (N(A)C) field theories, which also found applications outside the high energy physics area, for example in the study of the quantum hall effect.A further example of the relation between string theory and mathematics is provided by the great improvement recently achieved in the study of the AdS/CFT duality, when perspective and tools of the theory of integrable systems were applied to the problem.A two-year stay at the Department of Theoretical Physics in Uppsala would give me the opportunity to develop new mathematical skills by collaborating with U. Lindstrom in the context of sigma-model theory and N(A)C geometry and with J. Minaha n and K. Zarembo by applying my knowledge of Berkovits string to the AdS/CFT correspondence.My research activity would then be focused on the following main directions: - GCG and string theory. -New N(A)C geometries from string theory in non-constant back grounds and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards a European-wide exchange Network for integrating research efforts on Integrated Water Resources Management' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Integrated Water Resources Management (IWRM) is among todays core environmental policies in all European countries when transposing the Water Framework Directive - WFD. An analysis of 60 research programmes (ERA-Net SSA n° 003223), carried out in 13 EU countries, shows that, since 2000, transposing the Directive has considerably changed the content of national or regional government-funded research programmes. Identifying IWRM issues / research needs in the short and long term, improving social understanding about research, promoting interdisciplinary research works, constitute some of the main working axes of IWRM.Net network, in order to help the programme managers to enhance their practices The 17 partners, from 16 European MS, agree on a shared Vision of what should be IWRM.Net by 2010 : 1.THE source for knowledge about IWRM-research being undertaken in Europe, with a focus on the WFD 2.A forum for prospective and co-ordination of research needs and programmes on related issues in different countries, including accession states and EU neighbours 3.The facilitator between research and water policy makers and managers to bridge the communication gap 4.A facilitator for bringing together researchers and funders from different countries to work on joint projects 5.A forum for exchanging best practices on administrating research programmes across Europe Activities will include a Knowledge Management tool (WP1), analysis of research needs (short-term WP2 and long-term WP3), development of joint and trans-national activities (WP4), intensive linking with related initiatives and actors (WP5), and dissemination of outcomes to the stakeholders (WP6). The duration of the project is 5 years ; workshops will be organised for production, and 3 conferences will be scheduled for di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Predictions and Observations for Discs: Planetary Cores and dust Aggregates from non-ideal MHD Simulations with radiative Transfer.' in the context of a Horizon 2020 call.

assistant: **Objectives**

One of the most fascinating and challenging question of Modern Astrophysics is: How do planets form? Indeed, micronic dust grains must grow over 30 orders of magnitude in mass to build planet cores. Global numerical simulations of dust grains that couple the dynamics of the particles to their growth/fragmentation and the radiation in the disc are compulsory to understand this process. Yet, this coupling has never been realised, given tremendous difficulties that originate from fundamental physical properties of dusty flows. The evolution of the dust distribution in protoplanetary discs remains therefore very poorly understood. Our novel groundbreaking code is the first to handle non-ideal MHD, radiation and dust with dynamical growth and fragmentation. We can therefore overcome all past difficulties to model gasgrains mixtures in discs consistently. PODCAST is designed to study the different stages of gas and dust evolution in the various regions of the disc, with the main objective of combining these steps in a holistic model for planet formation. We will confront the results directly with observations, unleashing the full potential of the grand instruments ALMA, SPHERE, JWST and SKA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeting drug resistance in ovarian cancer through large-scale drug-response profiling in physiologically relevant cancer organoids' (RESIST3D) targeting Horizon 2020.

assistant: **Abstract**

Ovarian cancer is the fifth most deadly cancer type among women in Europe. Despite the fact that standard chemotherapy is usually effective in eliminating bulk tumour mass, thereby inducing remission, most patients diagnosed with advanced ovarian cancer die from the disease, as relapsed lesions emerge from small subpopulations of surviving drug-resistant cells. Precision medicine aims to improve cancer care through tailoring individualized therapies based on genomic or functional profiling of human cancers. However, as these approaches are usually performed on bulk tumour cells, the small pre-existing drug-resistant cell subpopulations remain untargeted.In the RESIST3D project, I will utilize ovarian cancer organoids – a patient-derived, three-dimensional cell cultures – to search for new strategies to eradicate drug-resistant cancer cells. I will use two organoid models developed for the same patient – one model derived from tumour material taken before chemotherapeutic treatment and one from a post-treatment sample, typically enriched in drug-resistant cells. I will further enrich the organoids in quiescent, drug-resistant cells by maintaining them in physiologic-like culture medium. I will then apply the models for drug-response profiling in order to identify agents that eradicate pre-existing drug-resistant cells, which could be combined with standard chemotherapy. Finally, I will assess whether the selected combinations prevent relapses in patient-derived xenograft mouse models.RESIST3D sets a new direction in precision cancer medicine, as it focuses on targeting small pre-existing subpopulations of drug-resistant cells rather than bulk tumour mass. Through combining organoid model, paired samples for each patient and physiologic culture conditions, I expect to ide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rural-Urban Outlooks: Unlocking Synergies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Mutually beneficial relations along rural – peri-urban – urban trajectories can contribute substantially to Europe’s smart, sustainable and inclusive growth agenda. Success in creating synergies is largely determined by decisions made at local and regional levels. Well-designed governance arrangements can be conducive to decisions that strengthen beneficial relations between rural and urban areas. Central to ROBUST is a place-based case study approach in which the case studies focus on thematic functional linkages cutting across rural-urban areas. The content and governance of these functional linkages are analyzed in diverse case study areas that represent the main types of rural – peri-urban – urban settings across Europe. ROBUST will identify and strengthen policies, governance systems and practices that can contribute more effectively to smart, sustainable and inclusive growth. Particular attention will be paid to the capacities of municipal and regional governments, the related administrations and other stakeholders to deliver and enhance mutually beneficial relations. ROBUST aims to provide practice-oriented information about successful governance models applicable to different settings as well as related communication and training material. In ROBUST, the questions and research needs of practice partners will guide the research process. Researchers will support the related multi-actor consultations through data collection and analysis, by providing suitable platforms and through facilitation. The insights co-generated by research and practice partners and stakeholders will be translated into tools, including scenario development, as well as training materials and capacity building measures. ROBUST will in this way contribute to a better understanding of rural-urb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities'.

assistant: **Concept**

Traditional valorisation approaches focus on linear processes: from academia to society. In order to bring valorisation to a higher level, all relevant actors need to cooperate in an equal setting: co-creation. Co-creation transcends boundaries, but it does not happen naturally. Therefore, the ACCOMPLISSH consortium, consisting of 14 universities from 12 countries (representing all the sub disciplines in SSH), will actively involve the other partners from the so called Quadruple Helix (industry, governments and societal partners) within the project. The project has chosen an Open Innovation approach. The ACCOMPLISSH project (Accelerate co-creation by setting up a multi-actor platform for impact from Social Sciences and Humanities) will create a platform for dialogue where not only universities are involved. The dialogue platform is organised in such a way that academia, industry, governments and societal partners equally contribute in identifying barriers and enablers of co-creation. The results from both practice and the theory of co-creation form the basis of the valorisation concept and will be tested in the project in a quadruple helix setting. This concept will be tested and developed in such a way that it is transferable, scalable and customized for academia, industry, governments and societal partners in the whole of Europe. The impact profile of SSH research could be far stronger and more visible than it currently is. There are significant barriers to the valorisation of SSH research which still need to be understood in detail. In order to push the envelope within universities, we acknowledge that next to SSH researchers, the research support officers are key players in valorisation of SSH research. The project will identify all barriers and enablers of co-creat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design of specific microcarriers for an assisted- bioremediation and bioelectrokinesis of soil contaminated with Polycyclic aromatic hydrocarbons' (DOSMFAAB).

assistant: **Concept**

Bioremediation is the use of biological treatment systems to destroy or reduce the concentrations of hazardous wastes from a contaminated site. The present project aims at a technological development which would allow application of bioremediation to sites where biovailability represents a limiting factor.The project will contribute by developing microcarriers and the necessary movement technologies using hydraulic conductivity and/or electric field in order to deliver oxygen, nutrients and exogenous bacteria from the injection wells into the contaminated zone. Microcarriers will improve the bioavailability of the organic contaminants favouring their desorption from the soil particle. The project is focuses on the organic contaminants polycyclic aromatic compounds, which represent a serious problem of the contaminated sites linked to the aromatic chronic or accidental spills of petroleum in soil.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effect of long-acting spatial repellents (LASR) vs indoor residual spraying (IRS) on malaria burden in western Kenya: a cluster-randomised trial' (LASR) targeting Horizon Europe.

assistant: **Abstract**

Evidence of the impact of long-acting spatial repellents (LASR) on malaria burden is urgently needed. We propose to conduct a rigorous, cluster-randomised trial to evaluate the effectiveness of LASR and indoor residual spraying (IRS) in Kenya. The trial will include 66 clusters (villages) in western Kenya where malaria transmission is intense. The clusters will be randomised to one of three study arms including: (1) LASR (intervention #1) with SC Johnson’s Guardian™ product, (2) IRS with pirimiphos-methyl (intervention #2), and (3) standard control (no intervention). All clusters will receive standard malaria control interventions, including long-lasting insecticidal nets (LLINs) distributed by the Kenyan National Malaria Control Program and malaria vaccines (as and when these are deployed). The evaluation will include repeated cross-sectional community surveys (conducted at baseline and then every 6 months for 2 years) to gather information on household characteristics and parasite prevalence in children aged 2-10 years, malaria incidence as captured through health facility surveillance, entomological surveillance, mosquito behaviour studies and insecticide resistance monitoring, qualitative research to explore barriers to delivering LASR and IRS, and an economic evaluation. The primary objective of the study is to evaluate the impact of LASR (Guardian™) as compared to standard control on parasite prevalence in western Kenya. We will test the hypothesis that parasite prevalence as measured in cross-sectional surveys will be lower in intervention clusters (villages randomised to receive LASR), than in control clusters (villages randomised to standard control). The field work in Kenya will be led by the Kenya Medical Research Institute (KEMRI), coordinated by the Liverpo