RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative complete production line for the manufacture of slate flooring tiles' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The growth potential of the slate sector would be enhanced by the introduction of automated productions. Thus, the aim of this project is to design a prototype of an automated line for the production of flooring slate tiles. The main objectives can be summarized as follow: -To create new slate products (flooring tiles, platforms, steps etc.) with similar finish than other ornamental rocks as marble and granite, but with different properties: slate plaquettes with four bevelling edges and of a very uniform thikness (up to 0,5 mm variations). Therefore, new products of high quality will be introduced in the construction sector. -To automate the production of slate flooring tiles, that would involve an increase in finished tiles from 25 m2/day to 300 m2/day and would satisfy the existing market demand. -To increase over 25% the material utilization in the cutting process. The research, directed to obtain an automated line for the production of flooring slate tiles. should be approached as follows: Raw material study. An analysis of the physical qualities of the stone will determine the characteristics of the cutting diamond and the calibration process. Design and building of the prototype considering: a new cutting process for slate flooring tiles, with a precision of +/-0,3 mm, a machine to even out the block edges after cutting, a calibrating machine to even the bottom side to give a surface parallel to the top after exfoliation, rectification of up to 3 mm and three calibration heads will be required, a washing tunnel, two drying tunnels (after washing and waxing respectively), a waxing tunnel including an analysis of wax behaviour to optimize the process. Some transport methods between one stage and the next.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development and commercialization of a kit for profiling enzyme activity in liquid biopsies' to be submitted under Horizon Europe.

assistant: **Abstract**

Ubiquitination is a post-translational modification (PTM) that is critical for numerous biological processes, including cell cycle, autoimmunity, immune responses, and cancer. This has instigated vast interest in targeting the ubiquitin machinery, and in elucidating ubiquitin-dependent events in pathologies. However, a key constraint is the lack of high-throughput methodologies for monitoring ubiquitination in clinical samples. Current tools mostly provide a qualitative sense of ubiquitin substrates and are limited by the need for unique expertise and large amounts of biological material. To address this gap, we have established a PTM-profiling tool that utilizes enzymatic activity in biological samples (e.g. liquid biopsies), enabling readouts of several PTMs, across thousands of proteins, for multiple samples simultaneously. We will employ our platform technology to the discovery and development of ubiquitin-related diagnostics and therapeutic agents in the field of autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reimagining Borders & Rights through the Voices of Displaced/Stateless Women in Nepal' in the context of a Horizon Europe call.

assistant: **Objectives**

Hannah Arendt noted in the 1950s that human rights are dependent on the ‘right to have rights’. Gaps continue to exist in provisions of (inter)national frameworks of rights and in how borders are experienced. It is in these ‘grey’ spaces created by such gaps that displaced and stateless persons inhabit—spaces referred to as borderscapes. By exploring borderscapes, we gain a view of Kathmandu's cityscape through the voices of displaced and stateless women, witnessing their intersectional resistances as they claim their rights. This approach decenters from legal status as a primary mode of analysis and uncovers underexplored imaginaries of rights and pathways for social change.Voicescape offers an avenue to reimagine rights by those in the borderscape. It aims to reshape rights-framed research and community-led change models for these women, contributing to Law and Development (L&D) by connecting with critical theories from border studies, gender studies, and beyond. This transdisciplinary perspective, grounded in epistemologies from the margins and critical-participatory research methodologies, shifts the focus from traditional legal frameworks to a bottom-up view of legal status. Voicescape hypothesises that these women establish counter-territorial epistemologies that reshape the relationship between the individual and the state.As a participatory action research project, it will facilitate inclusive dialogues between women and NGOs, leveraging targeted dissemination efforts. A collaborative research and communications plan will produce joint outputs, enhancing the visibility and impact of women’s voices in broader socio-political contexts. A subsequent placement period will further influence practice with community-driven solutions. Voicescape aims to conceptual and p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metastatic tumours facilitated by hypoxic tumour micro-environments' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing the potential of a successful treatment of the cancer patient. This project seeks to clarify the roles and functions of the hypoxic tumour micro-environment in relation to the survival of solid tumours likely to metastasise. We will gain new knowledge about molecular mechanisms behind hypoxia-driven metastasis, like the epithelial-mesenchymal transition (EMT) by several routes: (a): mechanisms related to cell growth- and cell proliferation (UPR, mTOR, CA9, HIF, Notch, and VHL), (b): angiogenesis and lymphangiogenesis, (c): metabolism and pH-regulation (d): the handling of reactive oxygen species (ROS). We will generate animal models for the study of the role of hypoxia in metastases and develop a bio-bank of tumour and blood samples for molecular diagnostic studies. We will identify and develop advanced imaging techniques and biomarkers and identify micro-metastases in bone marrow of patients to assist in the selection of appropriate stratification of the actual primary tumour’s and metastases’ micro-environmental conditions. We will also create a machine-learning based classifier of tumour hypoxia. The consortium has the necessary expertise to perform proof-of-principle clinical testing of new treatment strategies. We will thus perform clinical tests of new drugs developed to attack the regulatory mechanisms selected from the pre-clinical work and possible synergisms of combined treatments. We will also test new radiotherapy strategies for treatment of primary as well as metastatic tumours. Cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-modal, Endoscopic Biophotonic Imaging of Bladder Cancer for Point-of-Care Diagnosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Bladder cancer is among the most expensive diseases in oncology in terms of treatment costs; each procedure requires days of hospitalisation and recurrence rates are high. Current unmet clinical needs can be addressed by optical methods due to the combination of non-invasive and real-time capture of unprecedented biomedical information.The MIB objective is to provide robust, easy-to-use, cost-effective optical methods with superior sensitivity and specificity to enable a step-change in point-of-care diagnostics of bladder cancer. The concept relies on combining optical methods (optical coherence tomography, multi-spectral opto-acoustic tomography, shifted excitation Raman difference spectroscopy, and multiphoton microscopy) providing structural, biochemical and functional information. The hypothesis is that such combination enables in situ diagnosis of bladder cancer with superior sensitivity and specificity due to unprecedented combined anatomic, biochemical and molecular tissue information. The step-change is that this hybrid concept is provided endoscopically for in vivo clinical use.The project relies on development of new light sources, high-speed imaging systems, unique imaging fibre bundles, and endoscopes, combined and applied clinically. The consortium comprises world-leading academic organisations in a strong partnership with innovative SMEs and clinical end-users. Through commercialization of this novel imaging platform, MIB is expected to reinforce leading market positions in medical devices and healthcare for the SMEs in areas where European industry is already strong. The impact is that improved diagnostic procedures facilitate earlier onset of effective treatment, thus recurrence and follow-up procedures would be reduced by 10%, i.e., reducing costs. Usin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'GasFermTEC: Gas Fermentation Technologies ERA Chair'.

assistant: **Concept**

The GasFermTEC project aims to recruit an experienced researcher and research manager, to act as an ERA Chair, and lead a team of researchers at the Estonian Centre for Biosustainability (ECB) to support and coordinate the setup of (i) a research direction specializing in gas fermentation technologies, ii) structural changes at ECB to implement a new model of partnership between academia and industry, iii) a training centre on biosustainability. The ERA Chair will be an expert in the field of gas fermentation – intimately linked to the other research groups (e.g. synthetic biology, chemical engineering, bioprocessing) and other initiatives at the ECB (the CelESTial Teaming project and the SynBioTEC). It will lead to solutions to capture carbon through bio-based production of fuels and high-value chemicals from globally available feedstocks, including waste gases and syngas produced via gasification of municipal waste and biomass; an initiative that will positively contribute to the Environmental Challenges and to the Smart Specialisation Strategy of Estonia. Structural measures regarding the research strategy of the ECB and its positioning within an industry context will be established, including planning for i) an innovative cooperation structure, the ECB-Industry-Association and ii) an ECB Pilot Plant. The Association will coordinate activities of the Pilot Plant project for the industrial optimization of bioprocessing technologies. The pilot plant, combined with a training and competence centre, will provide the local bioprocessing industry with research-based innovative technology solutions, and serve as a broad public platform for a debate on biosustainability.With the GasFermTEC project, the ECB expects to increase its research capacity to become more visible and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Hearing Minds: optimizing hearing performance in deaf cochlear implanted individuals' under Seventh Framework.

assistant: **Concept**

The regular use of an adequate hearing aid increases the chance of keeping hearing impaired patients communicatively, socially and economically active. Many profoundly deaf patients are potential candidates for cochlear implantation. The optimal use of such a device requires that the cochlear implant speech processor be adjusted so that sounds perceived by the patient are representational and at a comfortable level. In prior collaborative research, new fitting processes have been developed to optimize the patient’s hearing in a more efficient and accurate way by means of an  assisted or (semi-)automated fitting procedure in which a large number of the cochlear implant speech processor parameters may be adjusted, based on measured psycho-acoustic feedback from the implant user. Such an assisted fitting process drastically reduces the number of man-hours of fitting during the lifetime of the device with qualitatively better outcomes. However, the state-of-the-art still has a number of short-comings: (i) the self-learning character of the currently used fitting model; and (ii) the limited input data with respect to speech perception testing in very young child populations.The main objectives of the proposed research project are to enhance researchers’ knowledge (i) of fitting models based on Bayesian networks to reinforcement learning models such as partially-observable Markov decision processes (POMDPs); (ii) of evaluation tools to measure functional hearing capacities in ‘difficult’ listeners such as young children or elderly adults.Due to its multi-disciplinary and combined fundamental and applied nature, the proposed research crucially depends on the transfer of knowledge to create a common framework for hearing scientists bringing together insights from different disc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Geochemical, mineralogical and petrographic studies of the newly drilled natural fission reactor at Bangombe -Gabon'.

assistant: **Concept**

The subject of this study is the natural fission reactor of Bangombi (Gabon) representing a very high grade uranium ore where fission reactions occurred 2.0 billion years ago. As the reactor is located close to the surface, the surrounding rocks are influenced by contemporary weathering under tropical conditions. Moreover, hydrothermal alteration took place in the period of criticality. To determine the effects of such alteration processes on the behaviour of actinides and fission products and to understand the main geological and mineralogical parameters and mechanisms influencing the retention and/or migration of these elements, it is proposed to examine one drill-hole and a weathered profile. Therefore, detailed mineralogical, geochemical and petrographic analyses such as scanning microscopy, transmitted electron microscopy, X-ray diffraction analyses, ICP mass-spectrometry, thermo-ionization mass spectrometry and gas mass spectrometry will be performed .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'An INClUsive toolBox for accElerating and smartening deep renovation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

InCUBE brings together 23 high-profile partners and two affiliated entities from 7 European countries, envisioning to unlock the EU renovation wave through cutting-edge standardized, lean integrated processes based on 4 key pillars of innovation: 1) Industrialization: Off-site manufactured solutions including the use of robots (e.g., demolition, telescopic cranes, drilling and waste sorting), so far applied only in industrial environments, offering novel services (e.g., anti-collision, area boundary, waste tracking); 2) Novel self-RES power producing and storage technologies, products and environmentally friendly materials (e.g. low GWP-refrigerant heat pumps); 3) Digitalization: Dynamic Digital Twins of both products and buildings, utilizing immersive capturing techniques (e.g., Laser 3D scanners and Drones), digitally merging innovative manufacturing processes with BIMs, and; 4) New market entrants, organized under novel business models, to allow for increased levels of collaboration and productivity. The InCUBE Suite, integrates digital tools across all 4 pillars, enables for seamless coordination of different renovation phases while leveraging data streaming from multiple interoperable sources to accommodate tenants’ comfort and render buildings active energy nodes in the synergetic energy networks paradigm of the future. Solutions will be validated in 3 large-scale demo sites (19,100 m2, >600 residents) in 3 countries (IT, ES, NL), including a cultural heritage building. Key expected outcomes include among others: Reduction of waste streams and time needed on-site by >35%, renovation cost reduction by >30%, reduction of working time with hazardous activities by >50%, energy savings >6GWh/y (78%), GHG reductions >1,980 tCO2eq/y, achieving an energy performance gap b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'MECHANISMS UNDERLYING CELL FATE DECISION BETWEEN PANCREAS AND LIVER'.

assistant: **Innovation**

Diabetes is a degenerative disease affecting millions of persons worldwide. A cure for diabetes depends on replacing the insulin-producing ²-cells in the pancreas that are destroyed by the disease. An attractive strategy to attain this goal is to convert liver adult cells of the same patient into pancreatic ²-cells. The liver and pancreas share many aspects of their early development and are specified in adjacent regions of the endoderm, possibly from a common bipotent progenitor cell. Therefore, conversion of liver to pancreas is conceivable and should imply only few steps backward to a common progenitor and little epigenetic changes. However, how pancreatic versus hepatic fate decision occurs during development is still poorly understood. The aim of this proposal is two fold: to perform lineage analysis, and to study developmental regulators of pancreatic versus hepatic fate decision. We will use new genetic tools, based on the GFP and photoconvertible Kaede fluorescent proteins, to address: i. if the liver and pancreas arise from a common bipotent progenitor cell; ii. to trace in vivo; and iii. molecularly profile the presumptive precursor cell and its descendants in the mouse embryo. Our previous studies have identified target genes of the GATA factors that might act as intrinsic developmental regulators of the pancreatic versus hepatic fate decision. Both intrinsic factors together with extrinsic regulators, such as BMP, will be studied. We will test their potential to promote lineage reprogramming of liver to pancreas using the mouse as well as mouse embryonic stem cells as model systems. Understanding how distinct cell types arise from common multipotent progenitor cells is a major quest in developmental biology. Our findings will elucidate the spatiotemporal mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Targeted Amphoteric Carriers in ImmunoTherapy' under Seventh Framework.

assistant: **Concept**

The past year has been exciting for oligonucleotide-based drug discovery and development. The Nobel Prize was awarded to Mello and Fire for discovering RNA interference. There was also big investment from the Pharmaceutical industry to Biotechnology companies-pioneers in oligonucleotide therapeutics such as Sirna, Alnylam and Isis, all US-based. High expectations were therefore raised but further progress is hampered by the issue of systemic delivery; siRNA oligonucleotides are ineffective in vivo whereas antisense DNA oligonucleotides can be effective for liver-specific targets only. Therefore, delivery systems are a matter of intense investigation with the most recent advances being cationic liposomes with PEGylation or diffusible PEGylation. However, these carriers face tolerability issues, non-specific immune stimulation or limited biodistribution. Novosom has developed a completely novel carrier system based on amphoteric liposomes. This incorporates structural features with unique charge-reversal properties which result into safety and performance advantages over the current best alternative carriers. The aim of this Consortium is to built on Novosom’s carrier technology to develop novel improved amphoteric liposomes with targeted delivery modalities to cells of the immune system, and to apply them for therapeutic oligonucleotide delivery to inflammatory diseases.  Knowledge transfer between partners will facilitate the design of novel carriers, identification of targets and validation using in vivo models of inflammatory disease. The Consortium stems from two very successful one-to-one collaborations and proposes here a fully integrated program of translational, interdisciplinary research. Knowledge transfer between Novosom, a European leader in oligonucleotide d