RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'a MULTIDISCIPLINARY STRUCTURAL GLYCOBIOLOGY RESEARCH NETWORK FOR the STRUCTURE ELUCIDATION, DESIGN AND SYNTHESIS OF FUNCTIONAL CARBOHYDRATE determinants' (CARENET-2) targeting Fourth Framework.

assistant: **Abstract**

CARENET-2 integrates the subdisciplines, laboratories and international based, products, focused on an understanding of the molecular features of experts needed for effective research into chemical aspects of carbohydrate carbohydrate recognition. The research can be summarized as: recognition and thus creates an environment for authorative teaching of novel aspects and developments. CARENET-2 has workshops, symposia, In quest of the functionality of carbohydrate chains in bio-recognition and regulatory processes. A multidisciplinary structural glycobiology specialist courses and an annual conference directed towards research approach to the structure elucidation, design and synthesis of functional training. Specialist training stages and exchange programmes provide in carbohydrate determinants for chemical, biological and pharmacological depth training with a broad scope. The most important contribution is the on the job training: properties and their application for the generation of biomedically relevant products. Research is trained by doing research in a good research team. CARENET-2 integrates research into carbohydrate bio-recognition processes and deals with: structural glycobiology (structure determination, biological activity and theoretical aspects) PEGA-resins for solid-phase synthesis separation, purification and characterisation oligosaccharide synthesis (classical synthesis, chemo-enzymic approaches, solid-phase synthesis, building block and combinatorial approaches) establishing oligosaccharide libraries for synthesis and binding assays.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'OPEN SYSTEM ARCHITECTURE FOR TELEMATIC SERVICES IN MUNICIPAL APPLICATIONS' (OSA-TESMA).

assistant: **Innovation**

In OSA-TESMA, the usefulness of high-speed access to multimedia data for administration and planning in European cities will be demonstrated. Quality telematics is invariably crucial to the delivery of better, more cost-effective public services by local authorities. One project site will test applications for high-speed data access in urban planning, while another will focus on a comparable system for exporting information products. A clearer view throughout Europe of the telematics needs of urban administration in these and similar areas is expected as a result.The application of high-performance Telematics services in administrations in Europe is a key to better performance, higher productivity and to reducing costs for public services and authorities.Administrations need and provide information products while providing services. These information products accessible from outside become more and more the basic raw material" for many companies operating all over Europe. Networks which make the information products available are becoming more and more important, where each administration can individually set up the access rules and possible costs to be paid for providing the information products.In the OSA-TESMA project the focus in Karlsruhe is on the development, realisation, test and validation of a high-speed access to multi-media-data for the tasks of the adminstration and planning of real estates in the form of a comprehensive set of Telematics service. The usage will be internally by VLA (a department of the City Council of Karlsruhe) in order to build and maintain their databases and externally by system house KREUTLER in the development of guidance and control systems for security and rescue services.In Nancy the focus of interest is on developing, building up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'D-wavE Proximitiy effects in Topological Hybrids' in the context of a Horizon 2020 call.

assistant: **Objectives**

Topological superconducting matter has attracted much interest in the recent years, carrying the long-term vision of next generation of quantum electronic devices. Its potential stems from fundamental underlying properties, specifically the presence of topologically protected currents or low energy modes such as Majorana fermions.This project aims at exploring a novel type of topological superconducting matter solid-state device (Topological Josephson Junctions) resulting from coupling a high temperature d-wave superconductor and recently discovered two-dimensional Topological Insulators (2DTIs). The project will rely on 2DTIs made from transition metal dichalcogenides. These Dirac materials support 1D channels at their boundaries which are protected from backscattering by time reversal symmetry. While in proximity with a superconductor, superconductivity can be induced in the Quantum Spin Hall states, resulting in topologically protected superconducting 1D channels. If the superconductor is a high temperature d-wave, new devices can be envisioned based on the specific nodal pairing symmetries coupling with the 2DTI. This project aims at exploring the potential of such new devices for quantum electronics, leading the way to the realization of topological electronic devices and fault-tolerant topological quantum information applications.   This reintegration project relies on the unique complementary competences of the researcher on TIs (imported from his US post-doc) and of the host institution on high temperature d-wave superconductors and 2D materials. The acquired knowledge and IP training by the industrial partner will give the researcher a unique profile in the European research environment. This will give the researcher a strong edge to seek for a position at the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeting the Endocannabinoid System within Islets of Langerhans to Protect against Immune Destruction.' (DIRECtA) targeting Horizon 2020.

assistant: **Abstract**

Europe has the highest prevalence per capita of children with type 1 diabetes (T1D), an autoimmune disease with no cure that results in progressive destruction, and finally an absolute loss, of insulin-producing beta (β) cells in islets of Langerhans in the pancreas. This means that patients require exogenous insulin administration for life. Additionally, prolonged uncontrolled blood glucose levels increase the risk of cardiovascular diseases, peripheral neuropathy, renal failure and numerous infections. The endocannabinoid receptors (ECRs) CB1, CB2 and GPR55 are regulators of metabolism and immune action and are also present on β cells. Cannabidiol, a CB1 antagonist, reduced the incidence of T1D in mice by reducing insulitis, thereby preserving β cell mass. Additionally, blockade of CB1 alters insulin secretion, increasing proliferation and autophagy in β cells. Importantly, β cell-specific CB1 knockout mice have no T-cell infiltration in islets when their pancreas is challenged. Furthermore, activation of GPR55 and CB2 are reported to be beneficial in protecting from inflammation. In this project we intend to study the interaction of the ECRs and their potential synergy for protecting β cells from insulitis. For this purpose, we will generate a non-obese diabetic (spontaneously develops autoimmune insulitis) β cell-specific CB1 knockout mouse, and use pharmacological approaches to enhance GPR55 and CB2 signalling to determine if the diabetic condition can be prevented/ameliorated. We will assess β cell damage together with mitochondrial function, autophagy, and inflammatory responses in our mouse model and after pharmacological manipulation. Thus, this project proposes a new strategy, not focusing on the immune system but on the role that β cells themselves play in mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Improving Subseasonal and Seasonal sUmmer forecast over southern Europe through machine Learning' (ISSUL) under Horizon 2020.

assistant: **Objectives**

In the recent years, the continual improvements of weather forecasting models and the sustained need for reliable weather predictions beyond the weekly timescale resulted in the development of subseasonal to seasonal (S2S) forecast models and an intense research work from the scientific community. Despite the large number of research studies, S2S forecast models still show a limited skill in summer over Europe. In addition, southern Europe, has received much less attention, even though it is highly vulnerable to high-impact summer heatwaves, and very sensitive to climate change. The aim of this project, ISSUL, is to better understand and improve the S2S prediction of heatwave frequency and intensity and their associated weather patterns over southern Europe. To do this, a combination of two machine learning algorithms, an optimisation algorithm, to identify the best set of predictors, and a neural network, to provide non-linear predictions will be used. This approach has never been attempted before for these timescales. It is expected to perform better than standard S2S forecast models in predicting heatwave frequency and intensity and associated weather patterns and to bring larger improvements compared with traditional statistical forecasts that do not identify all the predictors and cannot represent non-linear complex interactions.ISSUL is divided into three parts. The first part aims at identifying the best set of predictors, using the optimisation algorithm, at evaluating it and understanding it is related to heatwaves over southern Europe via a dynamical analysis. The second part aims a predicting the frequency and intensity of heatwaves and associated weather patterns using a neural network. The third part aims at evaluating the performance of this combined machi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Systems prediction of Chronic Lung Allograft Dysfunction'.

assistant: **Objectives**

Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure.  Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients after 5 years post LT, it is currently impossible to predict the appearance of CLAD before the onset of first symptoms. This project aims to develop the SysCLAD model which will allow to predict, within the 1st year post LT, the recipients at risk of developing CLAD by 3 years post LT. Building upon available data from the cohort of lung transplantation (COLT, recruited since mid-2009), this project will integrate new LT recipients to form the European cohort of lung transplantation (ECOLT). The SysCLAD prediction tool will be based on a mathematical model developed through a system biology approach integrating both clinical and biological data collected from a total of 400 LT recipients. The model will be validated on the first 200 LT recipients (3 years follow-up at project start) and refined using the new set of 200 LT data with 3 years follow-up by 2014. The aim is to identify and validate the signature of CLAD both at the clinical and molecular levels to allow for an early recognition and specific interventions in patients at risk of CLAD. The implementation of the model is expected to significantly improve the cost-effectiveness of post-LT treatments, limit the risk of graft rejection in LT recipients and, ultimately lead to an improved quality of life and a prolonged life expectancy of patients following LT. Finally, the SysCLAD model holds further great promises in the cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanotechnology with Single Macromolecules' under Sixth Framework.

assistant: **Concept**

Molecular scale interactions at artificial and naturally occurring responsive surfaces, e.g. the cell membrane, play a crucial role in many biological and biomedical processes. Responsive surfaces with molecular level control are considered as key to many crucial problems in nano-biotechnology. We aim at contributing to the development of such surfaces starting from a fundamental understanding of structure-property relationships in advanced nano-materials and processes from the molecular scale. Specifically we propose to investigate the translation of external stimuli into forces in single macromolecules by means of atomic force microscopy (AFM) measurements for two classes of stimuli-responsive polymers, i.e. unique redox-active organometallic poly(ferrocenylsilanes) and elastin-based biopolymers. The communication with single molecules occurs via conformational/dimensional changes of these polymers under stress via changes in chain torsional potential energy landscape and thus variations in the corresponding macromolecular characteristic ratio. These occur upon redox stimulation or upon changes in e.g. temperature or pH.The challenging project will be tackled in a rational manner (control instead of trial and error) by depositing molecules individually at precisely defined positions using scanning probe lithography. Subsequently, the nano-mechanical properties of an ensemble of individually addressable molecules will be probed molecule for molecule by single molecule force spectroscopy, hence avoiding a convolution of data of many molecules. This approach will also be utilized to selectively pick up individual macromolecules by chemically functionalized tips, followed by AFM measurements that aim at unraveling the effects of several external stimuli on the macromolecu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Demonstration of solvent and resin production from lignocellulosic biomass via the platform chemical levulinic acid' (GreenSolRes) targeting Horizon 2020.

assistant: **Abstract**

The GreenSolRes project demonstrates the levulinic acid (LVA) value chain of lignocellulosic feedstocks to high-value products in a 3-step approach on TRL 6. First, a demonstration plant in Biorefinery of RWTH Aachen will be designed and build for conversion of lignocellulosic biomass to the platform chemical levulinic acid. Levulinic acid hydrolysate separation enables more efficient and purer levulinic acid production. In a 2nd step the versatile platform chemical levulinic acid is hydrogenated to 2-methyltetrathydrofuran (2-MTHF), gamma-valerolactone (GVL) and 1-methyl-1,4-butanediol (MeBDO) in a direct process developed by RWTH Aachen. These can be produced in the same reactor with a single catalyst by tuning the process conditions. In parallel, BASF will investigate the conversion of LVA esters to MeBDO and GVL. Third, the application of the products as solvents is validated in adhesives and the pharma sector as substitute of their less sustainable C4-analogues. Additionally, HENKEL studies the development of respective new polymers with improved properties. The basic engineering of first commercial plants for these steps supports rapid upscaling and exploitation after the project. This will release these products from the niche markets they are confined to due to ineffective existing production routes. At competitive prices compared to their petrochemical C4-counterparts these chemicals and related products will boost the bio-based market as they have a high greenhouse gas emission avoidance of at least 70% and an additional value to society via better health & safety properties. The whole value chain from e.g. forestry residues to consumer products is assessed for environmental sustainability, risks and health & safety to support business case development and mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Selective Plasmonic Sensors based on Quantum Electron Transfer' (SENQET) under Horizon Europe.

assistant: **Objectives**

SENQET aims to develop an advanced class of highly sensitive and selective plasmonic sensors based on quantum electron transfer phenomenon on optical fibre and chip platforms for detection of analytes down to picomolar concentrations. Its uniqueness lies in introducing an immobilization protocol loaded with several novel features for immobilizing metal nanoparticles on end facet of an optical fibre to fabricate the sensing probe, which besides being reproducible also enables monitoring of the fabrication process in real time, thus providing feasibility for batch fabrication of sensors. Through a synergistic nexus of quantum electron transfer phenomenon with optical fibre technology, SENQET aims to develop nanospectroscopic sensors for point-of-care applications in areas as diverse as environmental monitoring and disease diagnostics. While the quantum electron transfer effect imparts the sensor with excellent selectivity and hypersensitivity, use of an optical fibre for its implementation makes the sensor compact, easy to interrogate, and safe to use. This innovative and well-structured project will categorically produce many significant research outputs that will advance the knowledge on plasmonic sensors and give visibility to and promote the European research in this field. It will contribute towards establishing a cost-effective sensing technology and will bring about significant improvements in healthcare. Concurrently, the research and transferable skills to be acquired by the Fellow, including industrially relevant and entrepreneurial competences will immensely enhance his scientific expertise besides making him qualify as a highly skilled professional to establish his own research group in a leading European institute/university. Unequivocally, SENQET is expected
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural integrity of ceramic multilayers and coatings' (SICMAC), addressing dissemination and exploitation.

assistant: **Impact**

The training need in the field or ceramic multilayers is justified from the fact that these materials behave profoundly different from traditional metallic materials. Moreover, layered ceramics are at the basis of established as well as emerging technologies (MEMS). The project will establish a strong European research-training network in structural integrity of ceramic multilayers, ceramic coatings and functionally graded ceramics devoted to the microstructural and mechanical characterization of these materials. The programme is designed to build upon the expertise of the participating groups to develop a leading competitive position, by an integrated use of basic and applied science, in an area of major importance. Objectives of networking in training can be stated as:- Train young researchers at pre-doctoral and postdoctoral levels in issues involving structural reliability of multilayered ceramic structures and coatings.- Bring together research groups working in areas of(i) structural integrity of ceramics and(ii) processing of multilayered laminates and coatings, to work in a common research project to understand the failure mechanisms in structures made by dissimilar materials. As coatings and layered materials are processed by recourse to different techniques, the training provides an insight on the relationship between mechanical degradation.