RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular interconnections between transcription, translation and DNA repair in bacteria' (RNP5D), addressing dissemination and exploitation.

assistant: **Impact**

This proposal brings together the fields of bacterial transcription, translation and DNA repair with state-of-the art single-molecule biophysics in vitro and in vivo, biochemistry and structural biology to address a central but understudied question in biology: how are different macromolecular processes interconnected and functionally coupled? I aim to elucidate this by investigating the crosstalk between central processes in bacterial gene expression: transcription, translation and DNA repair.First, to understand what determines whether transcription is coupled to translation, we will reconstitute the complete transcription-translation system in vitro and image the process in real-time using cutting-edge multi-color single-molecule fluorescence experiments. We will support our dynamic single-molecule data with structural information from cryo-electron tomography. In order to verify that our in vitro data also have physiological relevance, we will electroporate reconstituted and labelled RNAP/ribosome complexes into live E. coli cells for multi-color single-molecule imaging also in vivo. Second, we will reconstitute the transcription-coupled DNA nucleoside excision repair pathway in vitro. Integrating multi-color single-molecule fluorescence with optical tweezer assays, will allow us to resolve a controversial point on how transcription-coupled DNA repair starts, comparing the established concept of Mfd-initiation with the newly proposed UvrD/RNAP-mediated lesion recognition.Finally, we will develop single-molecule experiments for integrating all three processes, specifically transcription, translation and DNA repair, into a single system to quantify cooperativity and competition between individual components and processes.Overall, this proposal will provide quantitativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reinforcement of research potential of the Department of Materials Engineering in the field of processing and characterization of nanostructured materials' (RP-DEMATEN).

assistant: **Innovation**

The Department of Materials Engineering (DEMATEN) at the Faculty of Technology, University of Novi Sad represents the strongest research and education centre in the province Vojvodina in the field of ceramics and polymer materials and one of the first research centres in Serbia in which investigation of nanostructured materials has begun in early 1990’s. Since then the research activities at DEMATEN have been focused on processing and characterization of nanostructured materials: nanopowders, nanotubes, nanofilms, nanocomposites. The objectives of the proposed project are reinforcement of research potential of DEMATEN and strengthening partnerships among centres of excellence established in the EU’s convergence region, the Member States and the Western Balkan Countries (WBC). This will be realized by: i) improving networking and exchanging of know-how and experience among the countries concerned through trans-national two-way secondments of research staff; ii) sending young scientists in the EU centres for training or to carry out specific research experiments; iii) reinforcing the human potential of DEMATEN (and three research centres from the EU’s convergence region) by hiring new young researchers; iv) upgrading and renewal of S&T research equipment and v) organising of workshops and conference. Achievement of these goals should enable the research group of DEMATEN to become expert and competent in the challenging field of nanomaterials and nanotechnology, to reinforce the WBC research potential and to contribute to sustainable research development by reinforcing S&T potential. The proposed project will explore the synthesis, characterization and processing of nanostructured materials as well as their integration into novel technologies. Realization of the project wo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Three years post-Tsunami: long-term effects of trauma in children aged 7-15 - a culture-sensitive approach' (POSTTSUNAMI), addressing dissemination and exploitation.

assistant: **Impact**

The Tsunami disaster ranks as the most severe natural disaster ever recorded in terms of the number of people who were directly affected. In the worst hit part of India, the Southern state Tamil Nadu, records show that 1,744 children under the age of 18 were orphaned and 1,450 lost one parent.  Few studies exist which investigate the long-term effects of trauma on children's and caregivers' well-being in developing countries. The aim of this project is to assess the three years post-event mental health status of children and caregivers from this region. The project will use a beneficiary-oriented approach and will focus to culture- and gender-sensitive issues.  Participatory research techniques, including adult as well as child key informants, will be used to identify indicators of children's and caregivers' well-being. Based on the developed indicators, interview guidelines for the caregivers will be formulated. Symptoms will be collected via questionnaires conducted in form of oral interviews using the following standards: The Child Behaviour Checklist (CBCL), the Children's Posttraumatic Stress Disorder Reaction Index (CPTSD-RI) and the Symptom Checklist-90-R (SCL-90-R). Tsunami-affected caregivers and children will be recruited from SOS Children's Village in Pondicherry and SOS Relief Programmes in Nagapatinam for whom specifically these interventions were set up. The psychosocial guidance, which will be developed upon the collected data, will focus to the strengthening of resilience. The guidance will be developed by following a procedural method and is therefore applicable to different cultures taking also gender issues into account. In particular, this guidance will develop a culture-sensitive measure for children's and caregivers' well-being in the aftermath of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Learning Intentions Following Evolution' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Understanding why a certain utterance was said by a participant in a conversation is fundamental for successful communication to take place. Notwithstanding the central role of understanding intentions in communication, this and other forms of pragmatic reasoning remain beyond the current state-of-the-art in Natural Language Processing (NLP). For this reason, critical applications of these technologies, such as personal assistants, remain limited to few hand-coded use-cases such as adding events to a calendar and fail to serve as general-purpose communicative assistants. This proposal aims at making significant progress towards genuine Natural Language Understanding (NLU).  It introduces a system that can reason about the pragmatic meaning of a sentence by searching for useful explanations in a space that represents all possible concepts (often called a ""Language of Thought""). Because such a search process is generally intractable, this project proposes to let the system discover the more efficient way to search. To achieve this goal, it will model an open-ended evolutionary process that is here hypothesized to lead to emergent exploration strategies.This project bridges Linguistics and Complex Systems with connections to Cognitive Science and Evolutionary Theory. To maximize its success probability, I will conduct it at the COLT Lab in Universitat Pompeu Fabra (UPF), a leading group in Computational Linguistics, with a secondment at Santa Fe Institute (SFI), a global leader in Complexity Science.""


**Keywords:** Pragmatics, Intentions, Exploration, RL, Emergent Evolution, Complex Systems, Artificial Chemiestry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a low-cost permanently installed microelectronic monitoring system for process plant' in the context of a Fifth Framework call.

assistant: **Objectives**

Leading international industries and safety organisations have indicated a need for the improvement and utilisation of permanently installed monitoring systems to detect signs of damage and its progression within plant. It is the aim of the project to supply a central control room with information from sensors to monitor structural integrity and therefore maintain containment. To detect early signs of this damage would reduce the potential for unplanned downtime, repair, and environmental pollution. This project aims to develop innovative and improved techniques in permanent sensing technology. Relevant technology advances could include new materials, new sensing techniques, microelectronics, sensor data processing, and use of global communication methods. The Small Electronics Network Sensor Integrity Tool (SENS-IT) is proposed to be the solution. It is proposed tube modular in form, the sensor module, the processing/ temporary storage module, and the communication module.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'NEXT GENERATION, ZERO-WASTE, DYNAMIC, MULTIVALORIZATION ROUTE BIOREFINERY FOR SUSTAINABLE BOTANICAL INGREDIENTS:SHOWCASING A REPLICABLE AND VERSATILE MODEL FROM EXTREMADURA TO BIO-BASED INDUSTRY IN EU' (SUSTAINEXT).

assistant: **Concept**

SUSTAINEXT is led by Natac and brings together 21 partners from Europe and Spain, 7 of them from the Extremadura region. The project will start in June 2023 and will last four and a half years. In summary, the technological objective of the project is to implement on an industrial scale a digital, dynamic, versatile, disruptive and multi-product biorefinery, with a processing capacity of 20,000 tonnes per year and following a NetZero Carbon strategy. This first-of-its-kind flagship will transform the plant-based ingredients sector, while showcasing and deploying a first-of its kind model likely to be replicable by the whole European bio-based industry. SUSTAINEXT aims to transform Natac's current production plant, located in Hervás in the north of Extremadura, into the most modern, digital, innovative and sustainable plant extracts factory in the world, placing the company and the region at the forefront of the sector at a global level. The model is based in the integration of the whole supply chain - from feedstock to end users - applying a disruptive circular model based on a smart dynamic analytical biorefinery (DYANA): a smart dynamic biorefining process for the cascade valorisation of feedstocks which is optimized batch-wise according to the initial composition of the feedstock to deliver maximum value with minimum environmental impact and ensure resource efficiency. DYANA will allow to achieve the complete valorisation of the processed feedstock with a zero-waste and zero-emissions ambition.SUSTAINEXT will be industrially deployed with six sustainably and locally sourced European feedstocks. Three medicinal and aromatic crops (rosemary, camomile, and lemon verbena) will be cultivated in Extremadura in disused tobacco fields as an alternative towards healthier crop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Memristive and multiferroic materials for emergent logic units in nanoelectronics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

To make a machine think like a human we should overcome the tyranny of the deterministic binary logic, inherent to the contemporary electronic circuits. While the realization of this emergent approach has long been suggested as a multi-valued and neuromorphic architecture of the logic units, the problem is that we haven’t discovered a material system that could implement it. Right now, silicon-based transistors can operate as “on” and “off”, so the new materials would have to find to consistently maintain more states and emulate the plasticity and self-organization of neuronal connections. It’s against this background we develop the Consortium within the RISE action “MELON”, involving academic members from EU Member States, France, Netherlands, and Spain, from the partner country, Argentina, and the SME from the associated country, Ukraine, with the objective to develop the innovative materials platform for the realization of the emergent computing circuits. We target three focus areas:   (i) to explore novel memristive oxide-based systems on silicon, with history-dependent conductivity, for emulating the neuronal connections in the brain,    (ii) to use the nano-scale multiferroic materials, hosting the multistable topological states to realize the multi-valued logic, and   (iii) to explore conducting 2D oxide interfaces as both novels 4-points memristive systems and interconnect elements for the computing circuits.  The Consortium combines the complementary expertise spanned from fundamental to applied chemistry and physics and from material science to (industrial or modern) nanotechnologies development with the solid interdisciplinary and intersectoral potential for skills transfer, staff exchange, and young researchers' training.


**Keywords:** Memrisors, Resistive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Qur’an and Qital. The violence against the Other in a historical critical deradicalizing perspective.' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main target is to provide a de-radicalized exegesis of violence against the Other in the Qur’an: from the first verse pronounced in chronological order to the last, without altering the historical reality and thus the cruelty of the Prophet Muhammad’s age, but deconstructing the sources of  contemporary neo-Salafist fundamentalism. Violence in its religious premise as well as its adoption in Islam, has become a normal praxis both in reference to a sharp increase in internal conflict: not only between Sunni and Shi’a, but among Muslims who support different radical points of view in relation to other religions: Christianity, Judaism, Hinduism, Buddhist and atheism. This topic could be considered very popular; however, the exegetical studies that focus on each individual verse on the relationship between the Islamic revelation and the violence against non-Muslims, are limited and usually not linked to a historical-critical and metaphorical approach. This work raises the triple target of understanding, first of all, where and when every single verse of “violence” was pronounced, the historical exegetical interpretation in relation to a literary and metaphorical understanding and finally the trivialized deconstruction adopted by Islamic fundamentalism today.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Building Performance Digitalisation and Dynamic Logbooks for Future Value-Driven Services' (CHRONICLE).

assistant: **Innovation**

CHRONICLE will deliver a holistic, life-cycle performance assessment framework and tool-suite for different building variants, supporting sustainable design, construction and/or efficient renovation and investment decision making. It will be methodologically integrate ongoing initiatives, like EPCs, Level(s), SRI, under the umbrella of the Digital Building Logbook concept. Performance will be assessed by means of well-defined KPIs, based on both static (by design) as well as dynamic information (sensor measurements) appropriately tailored to different types of use and building life-cycle phases (new or existing buildings under refurbishment). Continuous monitoring and analysis of the actual building performance over its lifetime, will be based on a powerful digital twin framework. The proposed data availability and accessibility within CHRONICLE will extend the limits of the EU energy related policies while the aggregated EPC advanced information will facilitate efficient energy planning. To this end, CHRONICLE will allow all stakeholders to realize in quantified terms the short- and long-term impact of the project activities, from policy to practice, and across the whole building life cycle. It will therefore promote evidence-based impact assessment practices to support policy coherence, design of smart penalties and reward schemes towards motivating energy consciousness, while also paying attention to the voice of market stakeholders (AECs, ESCOs, FMs) but also building owners and tenants/occupants, who are directly impacted by future regulatory decisions. CHRONICLE’s building performance assessment framework and tool-set will be demonstrated and validated in five pilot sites spanning the geographic diversity of Europe, namely in Spain, Ireland, Denmark, Greece and Sw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Defining the immunological interplay between fibroblastic reticular cells and anti-tumour T cells'.

assistant: **Objectives**

Lymph nodes are sites where immune responses are robustly initiated. Paradoxically, they are also very common metastatic sites, where tumour progression is well-tolerated. Robust evidence defines a role for fibroblastic reticular cells (FRCs) in preventing T cells from acquiring effector functions within lymph nodes, and deleting T cells that show self-reactivity. FIBROCAN will test the hypothesis that FRCs systematically shut down anti-tumour T cell responses, testing mechanisms of suppression in vitro and in vivo, and charting tumour antigen presentation by FRCs to T cells for the first time. At the frontier of stromal immunology and cancer biology, FIBROCAN was been designed to inform our fundamental understanding of metastatic cancer progression, particularly relevant to the implementation and design of T cell immunotherapies. This project provides the opportunity for a lasting and multi-disciplinary contribution in the high impact fields of stromal and cancer immunology.


**Keywords:** Stromal immunology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Immune-privileged, immortal, myogenic stem cells for gene therapy of Muscular Dystrophy.' under Horizon 2020.

assistant: **Concept**

Duchenne muscular dystrophy (DMD) is a devastating incurable disease, affecting thousands with heavy burden on health systems. This project combines the development of a safe, immune-privileged cell with genetic engineering to correct many dystrophin gene mutations for an efficacious and cost affordable therapy. The applicant pioneered systemic intra-arterial transplantation of mesoangioblasts (blood vessel-derived progenitors) that proved safe in DMD patients and is being implemented for efficacy. However, this personalised approach would prove prohibitively expensive for healthcare systems, as pricing of successful gene therapies is showing. We made the striking observation that human mesoangioblasts can be indefinitely expanded with a novel culture medium, even after genetic manipulation and cloning. Cells will be first genome edited to delete endogenous HLA (2-microglubin and class II CTA) while inserting tolerogenic HLA-E, fused to 2-microglubin and, as safety device, the Herpes Simplex Thymidine Kinase suicide gene with truncated NGF receptor for selection. Edited clones will be checked for genome integrity.  Selected clones will be engineered to express a small nuclear RNA (snRNA) that causes skipping of a given exon of the dystrophin gene. Due to the syncytial nature of muscle fibres, the snRNA also enters and corrects the genetic defect in neighbouring, dystrophic nuclei, thus amplifying of one log the therapeutic effect. Five different cell lines would correct the mutation in 60% of DMD patients.  The cell lines will be transplanted in humanized DMD mice and assessed for the ability to escape immune surveillance and to differentiate in dystrophin expressing myofibers, establishing pre-clinical safety and efficacy for an off the shelf, affordable product. The a