RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes'.

assistant: **Concept**

HappyMums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy, and the efficacy of interventions. It will interrogate a large collection of cohorts with multiple biological, medical, clinical, socio-demographic and environmental and lifestyle data to identify the most robust risk factors triggering depressive symptoms, but also moderators of the risk.By putting together unique human samples of placenta, chorionic villi and amniotic fluid, and animal models, HappyMums will improve the understanding of the neurobiological mechanisms affected by depressive symptoms in pregnancy that lead to alterations in the foetal environment, shaping offspring risk for developing negative mental outcomes. The use of three complimentary rodent models will allow to achieve a proof of causality, and the presence of an innovative fish model will elucidate the mechanisms specific to placenta by which adverse maternal conditions are transmitted to the offspring without the potentially confounding mitigating effects of compensatory postnatal maternal care. This knowledge will allow the identification of new targets for the development of novel medications, for the repurposing of existing medications or for the development of non-pharmacological interventions. HappyMums will also develop a digital platform where AI tools-based data can be collected, together with biological, clinical, medical, environmental and lifestyle data, through a mobile phone App that will be at the interface with clinicians via a dedicated dashboard. This will allow early screening of depressive symptoms, prompt diagnoses, personalized treatments, and the promotion of protective lifestyle attitudes. Overall, HappyMums will not only increase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Quantitative analysis of genes in single cells'.

assistant: **Innovation**

The partners will develop methods and instruments to analyze the copy number of nucleic acid sequences down to thesingle cell/single molecule level, with the goal of developing an early diagnosis system for a child disease, namelyhemophagocytic lymphohistiocytosis (HLH). The underlying technique is amplification based counting (ABC), enabling toquantify the copy number of genetic sequences with a resolution of about 100 base pairs in single cells. ABC is based onthe discovery that there is a strong correlation between the number of positive PCRs from a genetic sequence and thesequence copy number if the sequence is present only in a few copies per sample. The method provides a resolutionwhich is much higher than for Fluorescence In Situ Hybridization and works quantitatively with lower sample amounts thanquantitative PCR. To prove ABC's effectiveness for clinical applications the partners will develop a single cell manipulationunit that picks cells from a solution and transfers them onto an integrated PCR and hybridization slide (AmpliGrid). TheAmpliGrid contains dried-on PCR reagents as well as hybridization probes to detect the presence and specificity of thePCR products. The single cells on the AmpliGrid will then be processed automatically in an integrated PCR andhybridization machine (AmpliHyb). Clinical samples will be investigated in which copy number deviations are pathologicas in genetic diseases. As a model system QuAGSiC chose HLH which is hard to diagnose and fatal without specifictherapeutic measures, as well as trisomy 21 which is relevant in prenatal and postnatal diagnostics. For these applicationsthe project will cover the complete workflow from identifying the cells of interest to quantifying the copy number of nucleicacid sequences in clinical samples
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Astrocytic metabolism-driven epigenetics at the cornerstone of cognitive aging' (NeuroSTARS), addressing dissemination and exploitation.

assistant: **Impact**

Cognitive impairment is a major source of disability and dependence during aging. Up to 40% of dementia cases are attributable to modifiable environmental risk factors, namely lifestyle, which can be actionable for prevention before the onset of cognitive decline. Physical activity and nutrition comprise promising modifiable factors affecting cognitive aging, but how the lifestyle affects cognition is not fully explained. Because of their unique location at the interface between blood vessels and synapses, astrocytes are strategically positioned to translate lifestyle contexts into specific cognitive shapes. Work from our group has demonstrated that astrocytic metabolism is remarkably dynamic and alternates lactate, ß-hydroxybutyrate and acetyl-coenzyme A production. Importantly, preliminary data indicate that these metabolites directly bind histones within astrocytes as epigenetic regulatory adaptive mechanisms. In NeuroSTARS, we will address whether such epigenetic adaptation is dictated by lifestyle-driven modulation of astrocytic metabolism to underpin cognitive performance across the lifespan. In mice subjected to controlled physical activity and dietary contexts, in combination with genetic manipulation of pivotal metabolic pathways in astrocytes, using cutting-edge metabolism and cognition assessment tools, we will (i) identify how astrocytic metabolism adapts to different lifestyle contexts throughout life, (ii) decipher the lifestyle-induced metabolic pathways that impact on metabolites-driven epigenetic regulation in astrocytes, and (iii) define the mechanism that causally links lifestyle-induced metabolism-driven epigenetic regulation within astrocytes with cognition across the lifespan. The expected output will reveal that the metabolism of astrocytes is ins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Manycore Application Development and Modeling Environment' (MADAME) targeting Seventh Framework.

assistant: **Abstract**

The multicore revolution (parallel computing on a chip) is predicted by many to be a major disruptive change for the IT industry. The biggest challenges lie in the productive yet efficient usage of parallel computing resources for the large class of programmers who are not experts in parallel hard- and software architecture. Continuing industry trends leading to increased heterogeneity and asymmetry, together with execution environments that demand dynamic adaptability, will further exacerbate the programming challenges.The MADAME proposal is designed to help programmers develop efficient parallel programs by providing two complementary components. The first component is an efficient monitoring toolset for manycore computing that extends previous work in the area of OpenMP profiling. The second component is a modeling approach that lets users understand performance vs. productivity tradeoffs when developing their code and allows the detection of scalability issues by estimating run-times on platforms that need not be available in real hardware yet. The models are also designed to be used at runtime by upcoming manycore operating systems as a means to communicate quality of service (QoS) requirements and tradeoffs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Research for enhancement of work conditions aboard ships' (REWORD).

assistant: **Concept**

The REWORD project is interested in enhancements to ship design and management tools, with the inclusion of human factors specifications in design and management guidance documentation.The research Project will use Human Factors theory and experimentation to evaluate the effects of environmental conditions to which ship's crew and passengers are exposed at sea.Following this approach, the aims of the new Research Project are to :- Produce an inventory of adverse factors, and their effects on physical and psychological characteristics of the crew.- Produce an overview of the design and modelling tools currently adopted to help reduce adverse influences.- Assess alternative remedies by testing their effectiveness using simulation or full scale experimental techniques.- Provide a cost-benefit analysis of the more effective remedies.- Suggest tools and models to be adopted for the design of new ships and for the improvement of existing ones. %
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Microbial community nano-ecotoxicology: interplay between effects on structure and the consequent effects on function.' in the context of a Seventh Framework call.

assistant: **Objectives**

Nanotechnology is already used in a huge variety of applications with a resulting potential environmental exposure. However, we are still lacking sound scientific knowledge on the ecological consequences for natural environmental systems of exposure to man-made nanoparticles (NPs). While standard ecotoxicity tests can be modified for hazard assessment of such NPs, the tests and therefore the conclusions address the wrong endpoints such as high-dose effects on survival and reproduction. This may have little relevance to possible effects on structure and function of natural ecosystems predicted to be exposed to low doses. Therefore the overall aim of this project is to link modern molecular biology and nano-ecotoxicology to address the interplay between effects of engineered NPs on microbial community structure and function and the consequent effects on their ecosystem function roles and rescilience.By joining the disciplines of community ecotoxicology, modern molecular biology, high end NP characterisation techniques together and bringing their combined abilities to bear on natural microbial comunities collected from both aquatic and soil environments this project will contribute to an environmentally more realistic hazard and risk assessment of NPs for microbial communities. This project will use both true commercial and purpose designed examples of silver (Ag)- and zinc oxide (ZnO)-NPs both NP types being among the commercially most important NPs these days.An additional focus will be set on systematic investigations of how effects are governed by the NPs fate and behaviour in relation to the respective environmental matrix and crucial abiotic key factors.  The data will be submitted into a broader research context through major EU and UK-US projects analysing the envi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Chemistry and structure of aminogen radicals using chirped-pulse Fourier transform (sub)millimeter rotational spectroscopy' in the context of a Horizon 2020 call.

assistant: **Objectives**

To elucidate our understanding of amine chemistry in the interstellar medium (ISM), we propose a two-year project to study the physical and chemical properties of CH3NH and CH2NH2, the two simplest substituted aminogen radicals, using the state-of-the-art chirped pulse Fourier transform (sub)millimeter rotational spectroscopy. Amines are important N-bearing molecules in the ISM and planetary atmospheres,  as well as a trace molecule released to the Earth's atmosphere via various human activities. The simplest prime amine, CH3NH2, is proposed to be the precursors of interstellar glycine, the simplest amino acid. The physical and chemical properties of CH3NH and CH2NH2, however, are far from well understood. CH3NH and CH2NH2 are the intermediate products formed during the H-abstraction of CH3NH2 by UV photolysis or oxidation, which are important processes both in the ISM and in the Earth's atmosphere.These two radicals, however, are not directly observed in the H-abstraction process, neither have they been discovered in the ISM. Direct measurement of these radicals via rotational spectroscopy will provide us with detailed information about their molecular structure and chemical properties, which can be further used to search for their existence in the ISM, to study the reaction dynamics of H-abstraction of CH3NH2, and to determining their molecular structure and internal motions. The results will improve our understanding of the role of CH3NH2 in the chemistry of N-bearing molecules in the ISM and in planetary atmospheres. In this proposal, we will elaborate the approach and the implementation of the objective of the direct measurement of CH3NH and CH2NH2. Support information about the researcher, the supervisor, and the host institution is also provided.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Food Intelligence and Information Sharing for Business Collaboration enabled by the Future Internet'.

assistant: **Objectives**

This project will utilise technologies of the Future Internet PPP programme to enable the development and operation of intelligent systems for supply chains of perishable products such as food and flowers. The project includes an ecosystem that brings together: i) business needs of user communities and ii) creative ideas & technological opportunities of software SMEs and web-entrepreneurs. The corner stones of this ecosystem are regional clusters that include close synergies with regional developments & policies that are embedded in European networks. FInish will use the FIspace platform as a basis and aims to drastically enlarge the number of services/applications available in the FIspace store by involving through open calls SMEs and web-entrepreneurs as developers. As such, the FInish project will enable seamless B2B collaboration and it will empower companies including SMEs and new players to set up and participate in new regional, horizontal and vertical collaboration quickly and at minimal costs. By doing this, FInish wants to give an impulse to the shift from cost-driven to value-based, information-rich supply chains, which will significantly increase the added value, competiveness and sustainability of the domain. More specifically, FInish aims to:1. Empower small & innovative ICT players to develop high-quality and high-impact solutions for food and flower supply chain networks based on technologies of the FI-PPP programme2. Develop a large set of innovative and technologically challenging services and applications for virtualisation, connectivity and intelligence of food and flower supply chain networks3. Implement and validate the technologies and concepts developed in the FI-PPP4. Support SMEs in creating high-impact apps with Future Internet applications an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BIg DAta-driven MARKeting for better competitiveness'.

assistant: **Objectives**

Big data analysis has become a source of competitive advantage for businesses and even whole economies. Big data is indeed a critical issue for the digital economy, innovation and services that are expected to drive growth and job creation in the EU. Compared to the USA, however, the EU has been slow in the adoption of big data analysis. Fortunately, big data opportunities still exist in many business sectors to improve the competitiveness of European firms. In particular, performance may be improved by making use of big customer data to offer goods and services that better meet customer needs, i.e., “big data-driven marketing (BDM)”. However, adopting BDM has a steep learning curve due to organizations’ lack of understanding regarding the diverse factors required to succeed. The BIDAMARK project aims to assess the impact of different success factors on BDM, and consequently on firms’ ability to achieve superior customer performance. To answer this question, a comparative analysis between France- and US-based firms, and between industry sectors, will be implemented. A quantitative survey methodology will be applied with structural equation modelling (PLS) as the primary analysis method. This project is a perfect springboard for the Principal Investigator (PI) through the opportunity to build durable research networks, and acquire new skills that are complementary with his current expertise. New skills include research skills (theoretical and methodological), technical skills (use of new software tools), project management skills (lead of interdisciplinary project), language skills (French), and training skills (course teaching). Moreover, the publication of conference papers (later developed into high-impact journal articles) and recommendations for decision-makers will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'FRESHDETECT – food safety – fast and reliable' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

600 million (about 1 in 10 people) in the world fall ill after consuming bacteria contaminated food. Of these, 420,000 peopledie, including 125 000 children under the age of 5 years.Worldwide approximately 1/3 of all food produced is lost or wasted, requiring cropland area the size of China and beingresponsible for 8% of all global Greenhouse Gas Emissions. In the EU, every year 88 million tonnes of food are wastedrelated with costs estimated to be 143 billion euros. FreshDetect GmbH aims to contribute to a solution of these problemswith the first mobile handheld device developed for rapid determination of the microbiological quality of food (currently meatproducts). The FreshDetect device enables non-invasive microbiological testing without additional operational ormaintenance costs. For the first time, the handheld allows hygiene monitoring through the complete meat production processand creates a new dimension of food safety. Moreover, the FreshDetect technology offers a so far unmatched level of foodprocess control allowing an optimization of the food production and minimizing food waste.The current determination of total microbial count in laboratories outlined by §64 of the LFGB (German Food and FeedCode) takes about 72 hours to properly determine contamination. This renders impossible any process control that is basedon food contamination. The FreshDetect hand-held device needs only 5-10 sec. for the same process, is much less costlyand does not need scientific trained operators or lab technician.Starting with pork meat and having analysed the top 10 food processing European countries, FreshDetect’s market potentialis 284,000 devices with a market volume of € 3.5 billion. The target users are slaughterhouses, cutting plants, meatprocessing companies, retailers, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Developing sustainable water management in the Jordan valley'.

assistant: **Concept**

The main objective of this project is to develop the scientific basis for an integral management plan of water resources and their use in the Jordan Valley.Specific objectives are :* Development of a GIS-based database containing harmonised sets of population, land use, soil and water data of the Jordan Valley, including consistent sets of maps that project distribution of water sources and users.* Projection of potential available sources and demand of water until about 2030.* Assessment of the hydrogeological conditions, including a conceptual model for assessing environmental and health risks of current practices on soils and groundwater.* Identification of environmental and health risks of water quality degradation.* Evaluation of water collection, storage, delivery and irrigation practices and development of scenarios for water and soil management, regarding different land use practices.* Formulation of an optimisation model for water use, considering utilisation conflicts and potentials of conjunctive water uses.Expected OutcomeThe outputs of this joint project will provide a scientifically sound basis for better understanding the situation in the Jordan Valley and thus will directly benefit the future development, stability, and sustainability of the region. Final results will provide new knowledge about actual and projected water resources and flows in the regions including supply and demand. Result will allow to identify the impact of surface water diversions, irrigation practices, and water delivery methods on the hydrological budget of the study area thus leading to recommendations for optimizing the water usage in the region that will ensure sustainability and environmental protection.Key activities involve :* Collection and harmonisation of existing data on