RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Establishing Target Engagement and Selectivity for CTP Inhibitors in Cells: Synthesis and Application of CHOLesterol Probes for a Comprehensive MAPping of the Cholesterol Interactome', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cholesterol is a structural component of membranes and plays a key role in human health by regulating the fluidity of membranes and affecting signaling pathways. Intracellular cholesterol transport proteins (CTP) are responsible for maintaining cholesterol homeostasis by regulating local cholesterol concentrations, arising from de novo biosynthesis or dietary sources. Dysregulated cholesterol transport is associated with cardiovascular disease but also Alzheimer's and cancer. Despite the obvious importance of CTPs, a chemical probe to investigate binding, inhibition and selectivity profiling of CTP inhibitors does not exist. CTPs are all structurally related in their cholesterol binding site. Therefore, the development of a selective modulator to study their individual function and possible therapeutic relevance is challenging. Only a few CTP inhibitors have been reported so far and it has not been possible to conclusively evaluate their cellular selectivity. In CholMap, I aim to introduce a universal sterol-based affinity probe with the ability to bind all CTPs and evaluate the selectivity of CTP inhibitors in cells. This sterol-based probe would be bifunctional containing a diazirine, which is transformed into a carbene via UV irradiation for covalent binding to CTPs, and an alkyne for binding to a functional tag via click chemistry. I will synthesize differently constituted probes and test them in vitro for their efficiency. An optimized sterol-based affinity probe would be used in a chemoproteomic workflow to determine the target engagement and the selectivity of different CTP inhibitors. The introduction of a universal sterol-based affinity probe in combination with a chemoproteomic workflow would constitute the first example of CTP selectivity profiling in cells.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nano-satellites based Global Infrastructure to Enable IoT/M2M Networks - GIoT  (Global IoT)' (GIoT).

assistant: **Concept**

The global Internet of Things (IoT) market is expected to sky rocket in upcoming years by reaching up 200 bn connected devices in 2020 compared to 15 bn in 2015 and the total market value is expected to reach 1.48 Tn Eur. However, just mostly populated areas are covered with such services and approximately 80% of the globe is without connectivity. Exiting satellite based solutions are either expensive, hardly accessible for new operators and not tailored for newest applications and operations.  Consortium consisting of NanoAvionics nano-satellite bus provider, Atnwerp Space inter-satellite link subsystem provider for continuous connectivity and KSAT responsible for ground stations and communication with fleet of satellites will approach this challenge by providing integrated nano-satellite based infrastructure for real time communication for IoT/M2M operators. This infrastructure “constellation as a service” will provide at least 10 times cheaper IoT/M2M services, real time data exchange and significantly reduce number of barriers to enter for new IoT/M2M operators. The targeted applications are fleet management, agriculture, asset tracking, pipelines monitoring etc.  During the project, the nano-satellite based infrastructure will be developed from TRL 6 to TRL 8 together with piloting customer and after operations in orbit it will be prepared for scale-up with other companies which have signed 2 letters of support and 3 Piloting agreements. The estimated impact for participating companies is creation of additional over 190 million Eur in 5 years after project implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fatigue Damage and Healing of Bituminous Materials: from Microscopic Mechanism towards Lifetime Extension' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

FHBMicro aims to train a talented young researcher through an interdisciplinary research focused on investigating the microscopic mechanisms of fatigue damage and healing of bituminous materials (BMs) to fundamentally extend the materials’ service life. The main deliverables resulting from the FHBMicro include a better understanding of the microscopic mechanisms of the BMs’ fatigue damage and healing, a trans-scale performance prediction framework and evaluation protocol of the fatigue and healing of the BMs, and an implementation of anti-fatigue and self-healing BMs and technologies in durable and sustainable road construction. Through the project, the Fellow will receive intensive scientific knowledge training in multidisciplinary field of chemistry (TUD), material science (TUD), computational modelling (TUD and RWTH), experimental characterisation (UoN) and industrial applications (Nynas and Duro Vermeer). The Fellow will also receive inter-sectoral complementary skills training in project management, intellectual property protection, teaching and supervision, and networking. The benefits brought by FHBMicro are represented by strengthening the EU scientific excellence and industry leadership in the innovation, evaluation and engineering application of the durable and sustainable road materials. The implementation of anti-fatigue and self-healing BMs and technologies in road infrastructures will extend the road service life and ultimately save natural resources like petroleum bitumen and reduce greenhouse gas emissions. Uniquely, the project will enable the Fellow to obtain interdisciplinary knowledge and inter-sectoral complementary skills by building a new and exciting research field, which will pave a solid foundation for the Fellow towards his career of being an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Socio-Demographic Inequality in Climate Change Impacts' in the context of a Horizon Europe call.

assistant: **Objectives**

As climate change and extreme weather escalate across Europe, understanding the socio-demographic dimensions of climate events, environmental hazards, and their health consequences becomes increasingly vital. This is particularly important for designing more equitable strategies of environmental protection and climate adaptation, as well as facilitating healthier and more just societies. SOCIO-CLIMP has three primary objectives. 1) Investigating socio-demographic inequalities in exposure to extreme weather events, including their intersection with environmental hazards. 2) Analysing the disparities in vulnerability to extreme weather events - physical and mental health impacts of exposure - according to socio-demographic characteristics. 3) Evaluating how variations in individual and residential contexts contribute to inequalities in exposure and disparities in physical and mental impacts.SOCIO-CLIMP analyses the socio-demographic correlates of exposure to climate events and environmental hazards using harmonised demographic data across 30 European countries from the 2021 census at a granular spatial resolution. It combines the spatial data with individual-level panel data in the UK and Germany to provide groundbreaking insights into the physical and mental vulnerability (as the cumulative health burden) of different socio-demographic groups to these climate events.SOCIO-CLIMP represents an innovative effort to understand the socio-demographic inequality in climate change impacts across Europe. It will transform our comprehension of who is exposed to climate change, where specific sub-populations are particularly exposed, how vulnerable these groups are to exposure, and what can be done to effectively mitigate the negative impacts. It will uncover vital insights into so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Revealing Earliest Animal Domestication in the Fertile Crescent' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Animal domestication is a key topic in Neolithic archaeological research since the early 1960s. The earliest steps of this phenomenon are, still today, very difficult to achieve. Traditional zooarchaeological analyses used to date domestication rely on detecting the appearance of genetically-driven morphological changes in animals. These morphological markers, however, if they occur at all, only appear after the process is well underway, after hundreds, if not thousands, of years, making it difficult to study them. The READ project will build an alternative approach to detect early evidences of sheep and goat management. The project will investigate the historical life-traits of the animals with a high-resolution time analysis by performing biogeochemical analyses on fossil teeth. Scientific approaches employed are not all highly innovative but their combination together with the themes addressed will involve a high-gain. This will allow reconstructing the three clue mechanisms that were pivotal in the lead up to domestication: the control of the animals’ reproductive cycles; the induced changes to their feeding habits; and the interruption of migratory-seasonal movements. The project will evaluate and compare data from what are known to be the three key regions for this research area: the Southern Levant, the Northern Levant and the Eastern Fertile Crescent. READ will analyses a set of the most important and significant available faunal assemblages for these regions and will put together a reference dataset from wild relatives available in museum collections and current living populations found in breeding centres. At the end of the project I will unravel the current unresolved paradigms on the origin of animal domesticates not relying on how the animals changed but ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biodiversity and Vulnerability of European Cold-Water Coral Reef Ecosystems' (ECCRE).

assistant: **Concept**

Recent research from the Atlantic Coral Ecosystem Study (ACES) detailed over 1300 species from cold-water coral study sites along the EU continental margin. However, the biodiversity and vulnerability of these ecosystems remains unknown and this proposal aims to extend on the results of the 5th Framework ACES project by examining the extent to which cold-water coral reefs in northern Europe support a high biodiversity, and to assess the vulnerability of associated epifauna by building on existing and enhancing expertise between the fellow and the host institution at the Scottish Association of Marine Science (SAMS).   There are three research objectives:  (1) to describe and quantify biodiversity of cold-water coral reef fauna from Darwin Mounds and Mingulay Reef,  (2) to compare biodiversity across depths, and  (3) to evaluate the vulnerability of cold-water coral reef epifauna to sedimentation.   The fellowship links the expertise of the fellow in epifaunal taxonomy, regeneration studies, and sedimentation impacts with complementary expertise provided by the host in taxonomy, in situ environmental monitoring, deep-water species cultivation, scientific diving, and cold-water coral research. The fellowship mutually benefits the fellow and the host as it creates and fosters long-term international collaborations while transferring vital taxonomic and technological knowledge between partners that reinforce the scientific excellence of the European Research Area.   Working in collaboration with a European research centre that has taken a central role in pan-European marine research initiatives will greatly contribute to the professional development and independence of the candidate. This period of mobility benefits both the fellow and the host as a cost-effective method fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'EXPLORATHON '18 and EXPLORATHON '19 - EUROPEAN RESEARCHERS' NIGHT SCOTLAND'.

assistant: **Concept**

European Researchers Night SCOTLAND 2018-2019 will deliver two exciting editions of European Researchers' Night across Scotland in 2018 and 2019 guided by our ethos of 'Research for All'. Our partnership builds on our successful, highly visible, EXPLORATHON concept which reached over 36,000 people live and achieved over 10-million twitter impressions from 2014 to 2017. Led by five of Scotland's major research-intensive universities with over 600 EU-funded research projects between them, EXPLORATHON 18-19 will bring research to the public and foster a new dimension of collaboration with business and industry, building on themes of careers and Responsible Research and Innovation (RRI).Our headline - ONE NIGHT, UNLIMITED DISCOVERY - provides a public friendly message designed to engage audiences not traditionally interacting with research or researchers. We are benefiting from our nationwide partnership to introduce robust researcher training ahead of the NIGHT projects ensuring that researchers and publics have the best experience possible.At the heart of our proposal lies a vibrant, multi-element programme of activities, all designed to break down barriers between research and external actors of different backgrounds, ages and interests. Formats of cafe discussions, comedy, performance, hands-on activity, talks and debates will combine to highlight the relevance of research and challenge perceived stereotypes of researchers.Our venues will include public places such as shopping centres and cinemas but will also features 'doors open' access into research environments where discovery is actually happening, universities and industry. We will highlight the multidisciplinary and collaborative nature of modern research, helped by MSCA Fellows and EU-funded project exemplars. W
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Ensiling and grazing of energy-rich grasses with elevated sugar contents for the sustainable production of ruminant livestock'.

assistant: **Concept**

The project aims to provide a sound scientific basis for using novel grasses, bred for high sugar content using conventional breeding methods, in grassland-based agriculture. At certain times of the year, these grasses contain up to 400 g sugar-1. We propose to use these grasses, both grazed and ensiled, on their own, and in combination with protein-rich legumes, to improve the efficiency of ruminant production in sustainable livestock systems. The regional focus in northern Europe's the less favoured rural, upland and alpine districts where high-energy forages such as forage maize cannot be grown. Preliminary work has shown that throughout the year, grasses bred for elevated sugar content contain more sugar than the conventional varieties currently used in ruminant agriculture and that when fed, significant production responses and environmental benefits are achievable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving Cold Chain Energy Efficiency' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ICCEE (Improving Cold Chain Energy Efficiency) project will facilitate Small and Medium Enterprises (SMEs) in the cold chains of the food and beverage sector to undertake energy efficiency measures (EEMs) after carrying out supply chain energy audits. The focus on the cold chains of the sector is due to the significant energy requirements (refrigerated transport, processing and storage) with large potentials for savings. The implementation of the holistic approach, shifting from the single company perspective to the chain assessment, lead to increased opportunities for EEMs. To enable the update of EEMs, ICCEE will a) implement and apply an analytical energy efficiency tool to support and facilitate decision-making at different company organisational levels and b) launch a capacity building program towards staff and relevant stakeholders and a community dedicated to support a change in energy culture of the sector. The feasibility of EEMs will be evaluated by considering economic, environmental and social impacts encompassing their entire life cycle and the entire supply chain. Non-energy benefits and behavioural aspects will also be addressed and recommendations on financing schemes for SMEs will be assessed. The first part of the trainings will reach 300 companies through 20 national workshops thanks to the collaboration of associations in the consortium. 32 companies will be trained for the use of the tool in 4 EU workshops. At a final step, ICCEE will launch e-learning courses, which will be available also beyond the project’s lifetime reaching at least additional 64 companies. ICCEE will introduce primary energy savings (118 GWh/year), increase invested capital in sustainable energy (64 million €), and reduce GHG emissions (40,376 tonCO2/year). Capacity buildin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Modelling Mediterranean Ecosystem Dynamics' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Several EU funded research project have been developed on different aspects related to desertification and land degradation in Mediterranean ecosystems. It is now well understood that socioeconomic impact triggers degradation processes by imposing disturbances in the complex interactions of physiographic factors like plant growth, soil formation, water availability and erosion processes. The first theoretical assumption behind this proposal is that the understanding of ecosystems changes, needs to be based on the analysis of vegetation dynamics as it is plant cover which protects the soil from erosion and determines ecosystems functions. The second assumption is that computer based simulation modelling is now generally recognized as a very important tool in ecological research. It must be recognized that below ground processes represent a big hole in the current knowledge and yet they fit very clearly into the framework of desertification research established over the last decade. This study will try to be cutting new ground by addressing these problems, but starting from the strenght of established results. The following will be the specific tasks to be achieved: Modelling work will implement a new modelling environment and new models of plant community dynamics including below-ground processes and roots on the base of existing simulation software (Modmed II project). At the individual plant level ecophysiological studies will be performed on biomass allocation carbon and nitrogen partitioning. At the plant community level information will be collected on seed bank, seedling establishment, and below-ground structures and processes. At the vegetation landscape level pedoanthracological analysis will extend the historical analysis of vegetation changes and satellite remo