RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Vaccine Media Analytics' (VACMA) under Horizon 2020.

assistant: **Objectives**

One of medical science’s greatest achievements is the development of vaccines. Even if availability is improving, prices are dropping, evidence of effects are increasing and the side effects are fewer, an increasing number of people av voluntarily choosing not to accept vaccines.This project do not focus on the very visible group of active vaccine opponents, but instead on the less visible group where vaccine is just one of many other issues in daily life. From a public health communication point of view this group is particularly interesting since they is in a phase where they are deciding if they should vaccinate. This group have been hard to study since they are hard to target both with traditional surveys and interview and by traditional media analytics only.The project will use a mixed method approach for identifying and understanding this group. The methods will have a particular focus on machine learning techniques and semantic analysis. The choice of methodology together with the hosting at FISABIO and the University of Valencia coupled with secondments at the Vaccine Confidence Project at  London School of Hygiene & Tropical Medicine and with the SME Salumedia, gives the candidate an ideal environment for improving his scientific career.


**Keywords:** eHealth, vaccines, public health
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Design principles and controllability of protein circuits'.

assistant: **Concept**

Cells use circuits of interacting proteins to respond to their environment. In the past decades, molecular biology has provided detailed knowledge on the proteins in these circuits and their interactions. To fully understand circuit function requires, in addition to molecular knowledge, new concepts that explain how multiple components work together to perform systems level functions. Our lab has been a leader in defining such concepts, based on combined experimental and theoretical study of well characterized circuits in bacteria and human cells. In this proposal we aim to find novel principles on how circuits resist fluctuations and errors, and how they can be controlled by drugs: (1) Why do key regulatory systems use bifunctional enzymes that catalyze antagonistic reactions (e.g. both kinase and phosphatase)? We will test the role of bifunctional enzymes in making circuits robust to variations in protein levels. (2) Why are some genes regulated by a repressor and others by an activator? We will test this in the context of reduction of errors in transcription control. (3) Are there principles that describe how drugs combine to affect protein dynamics in human cells? We will use a novel dynamic proteomics approach developed in our lab to explore how protein dynamics can be controlled by drug combinations. This research will define principles that unite our understanding of seemingly distinct biological systems, and explain their particular design in terms of systems-level functions. This understanding will help form the basis for a future medicine that rationally controls the state of the cell based on a detailed blueprint of their circuit design, and quantitative principles for the effects of drugs on this circuitry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INNOVATIVE COMPACT SYSTEM FOR CHLORIDE REMOVAL IN THE STEAM PHASE IN GEOTHERMAL PLANTS', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The project is aimed at the design, field demonstration and testing of an innovative compact equipment for the scrubbing of geothermal steam.A full-scale compact steam scrubbing unit, able to process the steam feeding a commercial 20 MW power plant (110 t/h) was designed, manufactured and field tested. This unit is constituted of a column equipped with a structured packing operating in co-current.The project is aimed at recovering part of the energy loss associated with the steam scrubbing process, making it possible to reduce the amount of scrubbing solution that has to be used.The results of all the test campaigns confirmed the high chloride scrubbing efficiency of the column: chloride abatement was always higher than the calculated figures from the model used to design the column, thus showing that the model can be used confidently. Residual chloride concentration in the outlet steam was in most cases below the detection limit of 0.5 ppmW, a very good result, aslo compared with conventional scrubbing plants. This high chloride abatement efficiency was confirmed in the long term, too.On the other side, an unexpected tendency to an increase of the steam pressure drop accross was noted, with the possibility of restoring the initial value by a different liquid distribution (temporarily liquid injection in the steam pipeline). This drawback was attributed to the design of the liquid distributor within the column. Uneven or poor distribution of the scrubbing liquid on the top of the structured packing may in fact be the cause of clogging by salt deposition in the upper part of the packing itself, thus decreasing the free area for steam passage. This was confirmed by pressure drop increasing faster at lower scrubbing liquid flow rates.To allow the smooth operation of the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Network for integrating novel technologies for food processing' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The Network of Excellence HighTech Europe facilitates the implementation of high-tech processing at industrial scale via strongly connected regional knowledge transfer chains consisting of basic-applied science centres (12 in total), industry federations (4), Innovation Relay Centre (1) and SMEs (5). Its main aim is to identify, develop and demonstrate potential, cost-efficient, innovations to be used by SMEs via a Science Cube approach and availability of high-tech pilot facilities. This approach links innovation sources (bio-, nano- and information and communication technologies), scientific principles and food engineering operations. In addition, industrial needs are mapped and linked with the results from the Science Cube approach, using a novel Lighthouse Watcher concept. New routes for implementation are developed such as a Knowledge Auction and an Implementation Award honouring full chain innovations. Next, knowledge transfer schemes elucidate feasibility studies and business cases based on unique patent portfolios convincing entrepreneurs and early adopters to acquire ‘lead market’ positions. Here, ethical, legal, social aspects and consumer perception regarding high-tech food processing are taken into account in order to set up a first, well-balanced Agenda of the White Book on high-tech food processing for policy and regulatory bodies. Dissemination of European findings and training & career development, especially for young scientists sharing spirit and enthusiasm with their senior colleagues in the Network of Excellence, allow attracting new stakeholders and next generations for a durable network finally merging into the future European Institute for Food Processing. Herein, critical mass and joint initiatives at the interface of the Food Manufacturers and T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Functional Glycomics Through Chemoenzymatic Synthesis' (SWEETPROMISE).

assistant: **Innovation**

Almost all cell surface proteins are modified by covalently-linked carbohydrates and the glycan structures on these glycoproteins are mediators of many physiological and disease processes. Despite their importance, there are no methods available to systematically and efficiently produce libraries of complex glycans to investigate specificities and biology of glycan binding proteins. To address this deficiency, we will develop chemoenzymatic technologies that can provide large collections of glycans having architectures of unprecedented complexity. It will exploit chemically modified sugar nucleotide donors that can be transferred by glycosyl transferases to give products in which artificial entities will blocks specific sites from enzymatic modification. It will provide full control over branching, sites of fucosylation, sulfation and sialylation. The chemical entities will be chosen in such a way that they can be removed after a series of enzymatic transformations. The methodology will be employed to prepare a series of keratan sulfate oligosaccharides. These glycoconjugates, which are biologically still poorly understood, have been implicated a multitude of physiological and disease processes. To further broaden the scope of the technology, a chemoenzymatic methodology will be developed to prepare sialosides that at C-4, C-7, C-8 and/or C-9 are modified by acetyl esters. The compounds will be used to develop a designer glycan microarray to identify ligands for glycan binding proteins. The focus will be on immuno-regulatory proteins and viruses that exploit cell surface glycans for infectivity. Cellular arrays will be developed to examine biological properties of hits identified in the microarray screening. The results of the studies will provide critical insight about
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Multi-stakeholder platform for sustainable aquaculture in Europe'.

assistant: **Objectives**

Europe has a strategy for sustainable development, a position that now includes the development and promotion of sustainable European aquaculture.To assist the implementation of this strategy, it is proposed to create a Platform for Sustainable EuropeanAquaculture, whose strategic objective is to provide consumers with, and demonstrate the benefits of, high quality, safe and nutritious farmed fish and shellfish products, grown under sustainable conditions. The actions proposed to achieve this objective are based on the development and implementation of sustainable aquaculture protocols based on low environmental impact, high competitiveness and ethical responsibility withregard to biodiversity and animal welfare.These protocols will be developed through stakeholder participation and will lead to the establishment ofsustainability standards, agreed by the European aquaculture sector and accepted by consumers. The protocols will provide consumers with balanced information showing the benefits of sustainable European aquaculture andits products. The platform will also focus on the transfer of existing knowledge to SMEs. This Co-ordination Action will be steered by the principal European stakeholders - the European Consumers'Organisation, the European Bureau for Conservation Development, the Federation of European AquacultureProducers, the European Mollusc Producers Association, the European Feed Manufacturers Federation and the European Aquaculture Society (EAS). Newly generated results from the 6FP Integrated Project SEAFOODplus will provide valuable input. Under the co-ordination of EAS, specialised working groups comprised of experts in the areas that influence the sustainability of the sector will produce draft protocols. Through a wider consultation phase, these draft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Networked @ appliances and services for the HOMe environment' (1998-2002).

assistant: **Innovation**

The project is dedicated to the promotion of broadband home network and to the proof of concept of an open, end-to-end and seamless network architecture, with the objectives to provide citizens with new emerging IP-based broadband services. The overall network architecture is based on an open service platform, which allow technical management of the residential gateway clusters, billing, remote access to home portal and services delivery. The project involves development of the open service platform and its implementation in the define network architecture.It involves also the integration of a broadband home network. The project is organised in 2 phases with demonstrations over PSTN and ADSL (phase 1) and over Ethernet and VDSL access network (phase 2).Objectives:The project is dedicated to the promotion of the Home Network and broadband value added services for the citizen. The approach is based on seamless, end-to-end and open network architecture.The objectives of @HOM are:1) To promote and demonstrate a seamless network access architecture that facilitate the delivery of emerging IP-based broadband applications and services;2)To implement an open network architecture, allowing integration of new services easily and independently of hardware specifications, facilitating interoperability, and creating new business opportunities for operators, services providers, and content providers;3)To allow connection to the home and to associated services from anywhere/any time;4) To promote broadband technologies for the home network;5) To contribute to standardization bodies, in time to impact decisions, in such a way that European networks specificities, and cultural differences are well taken into account.Work description:@HOM adopts a top down approach derived from a service
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cost effective corrosion and fatigue monitoring for transport products' (CORFAT), addressing dissemination and exploitation.

assistant: **Impact**

Corrosion damages and fatigue cracks are the main causes for structural failures of all surface transport products like ships, road tankers and railway tank cars. Examples are catastrophic ship accidents with a tremendous pollution of the maritime environment or fatal explosions during the use of transport vehicles. Although evolving defects have to be identified in time to enable appropriate repair, preventive maintenance activities are usually carried out on time driven basis. As example transport products for cargo like crude oil and pressurised gases have to be taken out of service for visual inspection and sub-sequent non-destructive tests (NDT). Findings have to be repaired later on. This procedure is time consuming and expensive, especially the lost service time decreases the competitiveness of the European transport industry. Despite this high effort the risk of not detecting the onset of a defect is still implied in this maintenance process and thus failure within the next service period may occur. The proposed maintenance process is based on monitoring the status of the structural integrity in terms of developing fatigue cracks and active corrosion using the Acoustic Emission (AE) technology. It is proven, that AE detects active cracks, and based on the results of EU-funded project “corrosion detection of ship (EVG1-CT-2002-00067)”, it is evident, that AE is able to detect and evaluate active corrosion. By the application of AE sensors permanently on pre-determined hot spots of ships and tank cars the conventional maintenance and inspection can be replaced by a cost effective and condition based detection of defects and their follow-up in time. The result of the project shall be an overall strategy for the maintenance and inspection, including the necessary AE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Targeting transcriptional mechanisms in chronic inflammation-associated diseases' (TRANS-TAR), addressing dissemination and exploitation.

assistant: **Impact**

Chronic inflammation is causally linked to cancer development and most cancers contain an inflammatory infiltrate that is hijacked by tumour cells to promote angiogenesis, tissue invasion and cell proliferation. Moreover, autoimmune diseases with a huge social impact like rheumatoid arthritis are characterized by a chronic inflammatory state that is the main cause of damage and disability.The transcription factors (TFs) of the NF-kB family are crucial regulators of acute and chronic inflammation, whose excessive activity is linked to tissue damage and survival of cancer cells. Drugs blocking NF-kB activation in a global manner are in clinical trials, but concerns about their safety have been raised because of the many physiological responses in which NF-kB is required. Conversely, therapies blocking the induction of subsets of NF-kB-regulated genes should provide restricted and predictable effects, but the molecular basis for their design are not available. The aim of this project is to identify and validate protein-protein interactions between NF-kB and transcriptional partners, which are required for target gene induction and amenable to small molecule-based perturbation.We propose a rational combination of advanced technologies, including:i) a genetic app roach to the identification of companion TFs and co-regulators required for induction of subsets of NF-kB target genes;ii) in vivo analysis of co-occupancy of target genes by NF-kB and identified partners using chromatin immunoprecipitation;iii) in vivo visualization of interactions using FRET on visible clusters of NF-kB-regulated genes;iv) bioinformatics analysis and extraction of rules describing regulatory interactions.The generation of a map linking protein-protein interactions to the induction of subsets of NF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cabling vassiliev invariants for knots and related topics' under Fourth Framework.

assistant: **Concept**

Research objectives and content The discovery of the Jones polynomial led to a renaissance in knot theory but was problematic in that it was not understood in terms of classical ideas. Vassiliev invariants give one way of relating the 'quantum' knot theory to pre-Jones knot theory and topology. My intention is to continue my programme of understanding connections between Vassiliev theory and classical knot theory. The method will be by studying cabling operations on Vassiliev invariants. Cabling is a natural, classical operation on knots, and it is known that Vassiliev invariants behave reasonably well under cabling. Detailed study of this behaviour should reveal further insight into the algebraic structure of the Vassiliev invariants. It should also, for instance, allow the universal Vassiliev invariants of torus knots to be calculated. The Alexander-Conway polynomial is a classically very well understood knot invariant; it appears to be related to cabling operations on Vassiliev invariants. I will closely examine this relationship to try to unveil further connections between classical and quantum notions. Training content (objective, benefit and expected impact) I will be working in a World-class mathematics department with active researchers in my own and also in closely allied fields: this will provide a stimulating atmosphere and a broad mathematical background for my mathematical development. Links with industry / industrial relevance (22)