RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Third funding line in 2015 for the establishment of a European SST service provision function' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This 3SST2015 project is aimed at supporting the emergence of a European SST service built on a network of existing SST assets, notably sensors (radar, laser and telescopes) owned by SST Consortium Member States. This will require the commitment of Consortium Member States owing relevant assets to cooperate and provide an anti-collision, fragmentation and re-entry service at European level in order to increase the autonomy of Europe concerning the operational objectives derived from the SST decision, which will be partially fulfilled by the operation of the initial European SST system.Given that this system is mainly based on national systems, at the initial stage many of the activities will be based at national level. At the same time, and in order to achieve the convergence within a joint action that will allow the minimum desirable level of performance, an appropriate degree of coordination between SST Consortium Member States is needed.The project is following a shared working approach between the key players within the field of SST in Europe. Following the guidelines given by the implementing decision of the European Commission (C(2014)6342 final of the 12.09.2014), the backbone of the planned activity is formed by a set of SST committees forming the decision platform of the SST Consortium, composed of the five designated national entities in cooperation mechanisms with the EU SatCen.Three Committees  are foreseen for the governing structure of the SST Consortium: the Steering Committee as the decision platform, the Technical Committee as the professional motor and to the Security Committee dealing with bi- and multilateral aspects of security constraints and issues.The main activities are addressed in terms of: Performance assessment and architecture of SST, an SS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Night of Our Origins' (ORIGINS) targeting Seventh Framework.

assistant: **Abstract**

Last July, CERN announced the discovery of a new particle, confirmed to be the Higgs boson this year, responsible for the origin of particles’ mass. In March, the unprecedented resolution provided by the instruments installed onboard ESA’s Planck satellite, has revealed unexpected fluctuations in the temperature distribution of the primordial radiation of the Big Bang, providing an unprecedented insight into the origins of our Universe and a new picture of its composition today. Planck is painting a new picture of the Universe that is pushing the limits of understanding current cosmological theories. On Researchers Night 2013, we celebrate the multi-disciplinary teams of scientists who made these and other discoveries possible. We want to make the public aware that these are collective efforts involving thousands of researchers worldwide. We will offer the public at large in all its components, whichever their age and scientific background, the opportunity of discovering the ""human face"" of research via direct exchanges and discussions with the researchers, as well as understanding the impact of research on their daily lives. We will do it also by highlighting the cultural impact of these researches as well as the technological impact, focussing also on the medical applications of fundamental research.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Nanomaterial Synthesis in Highly Swollen Hexagonal Phases Templates'.

assistant: **Concept**

The swollen liquid crystals can be used as soft templates for synthesis of nanomaterials. These swollen phases can be doped with metal ions at very high concentration without perturbing the initial structure. Our previous studies on lyotropic liquid crystalline phases (hexagonal or lamellar) with anionic surfactants have shown that it is possible to obtain nano materials (metals, oxides or polymers) of various morphology: fibres, nanowires, lameis... within these confined systems. The present project is aimed at the synthesis of metallic nanostructures (using chemical and radiolytic reduction techniques), their characterisation and properties. The idea is to extend the synthesis to other liquid crystalline phases (hexagonal, cubic and sponge) obtained with cationic and nonionic surfactants and doped with various metals : Pt, Pd, Sn, Ag, Co, Ni. Small Angle X-ray Scattering experiments will allow us to analyse the structural characteristics of the doped liquid cystals. Chemical and radiolytic methods will be used to reduce the metal ions inside the mesophases and to obtain metallic nanomaterials of various shapes. First reduction and aggregation steps will be studied by nanosecond pulse radiolysis. Various techniques will be used to characterise these metallic nanomaterials: TEM, EELS, XPS, SAXS, AFM...We will be studying the relationship between the morphology and the catalytic activity of these nanomaterials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'IMmune MOdulating strategies for treatment of MErkel cell Carcinoma' (IMMOMEC), addressing dissemination and exploitation.

assistant: **Impact**

Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer of the skin associated with the recently discovered, common Merkel cell polyomavirus (MCV). With an incidence of 0.44 per 100,000 MCC is a very rare cancer. Notably, however, although MCC is 40 times less common than malignant melanoma, MCC has a dramatically higher mortality rate than melanoma rendering MCC to the most lethal skin cancer (37 versus 15 percent). This high mortality rate is largely due to the fact that to date none of the currently available therapeutic interventions is able to improve overall survival of patients suffering from metastatic disease. Consequently, new therapeutic strategies are needed for metastatic MCC. Since several lines of evidence indicate the outstanding immunogenicity of MCC, immune modulating treatment strategies are particularly attractive. IMMOMEC is a 5-year project to establish and investigate an innovative and effective immunotherapy for MCC, thus directly responding to the aims of the topic HEALTH-2011.2.4.1-1 Investigator-driven treatment trials for rare cancers.IMMOMEC will develop a rational immune therapeutic approach for treatment of patients with MCC that is based on the targeted delivery of interleukin-2 to the tumor microenvironment. However, IMMOMEC will not only provide a new therapeutic option for MCC patients, but will also establish the relevance of immune modulating strategies to treat solid cancers in general, establish and validate new tools to monitor patients receiving such therapies as well as compile prognostic and predictive biomarkers to individualize immune modulating therapies. Moreover, IMMOMEC will introduce a new immune modulating therapeutic produced by a European SME, which also holds the intellectual property r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-electroactive organic semiconductors for photovoltaic applications' in the context of a Sixth Framework call.

assistant: **Objectives**

The main drawback of organic solar cells is their effectiveness in converting sunlight into electricity: they run at approximately 20% of the efficiency of silicon devices. The development of plastic PV cells is still in its infancy and a range of strategies needs to be investigated in order to raise the efficiencies of these devices. We intend to prepare multigram amounts of active, organic materials, which will be assessed and assembled into PV cells. Our synthetic targets represent a range of new oligomers (short chain polymers with a precise chain length), based on oligothiophene and polythiophene systems and metallopolymers. These compounds need to be soluble, stable materials that can generate light-induced electron-hole pairs within the same molecule or in blends with suitable acceptor molecules.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular Ruthenium Catalyst for Fine Chemistry' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The project aims at the development of molecular catalysis for fine chemistry via the design of ruthenium catalysts and the discovery of new combinations of molecules. The use of new catalysts will improve the outcome of useful reactions, increasing significantly atom economy, mild conditions and selectivity. The development of new catalytic carbon-carbon bond reactions by ruthenium complexes, through the combination of simple and cheap materials (alkenes, alkynes, dienes) via clean processes, will contribute to new ways of production and sustainable development. Two approaches based on the activation mechanism will be considered, the first one involving the regio-selective oxidative coupling of two unsaturated substrates at the metal site through metallacycle intermediates, and the second one the activation of terminal alkynes towards nucleophiles via vinylidene intermediates. Target reactions will be the catalytic coupling of unsaturated hydrocarbon to perform a mild access to added value intermediates for pharmacy and to vitamin intermediates. The ruthenium catalysts will be of the type RuX(L)2(C5R5) and[Ru(L')(L)2(C5R5)]+, bearing labile L ligands, and ancillary L1 ligands such as phosphine, imidazolylidene carbene and others. For the second approach [Ru(L-L)(C5R5)]+ with tightly bonded chelating L-L ligands, in order to maintain only one vacant site. The C5R5 and X group scan be modulated in both cases by their electron-richness and steric hindrance to control catalytic activity and the regio-selectivity. A search for the optimal conditions will be carried out for all new catalytic reactions obtained by this approach, to improve yield or selectivity. The evaluation of catalytic activity will be carried out by HTE (High-Throughput Experiments) - Combinatorial Techno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sex-limited experimental evolution of natural and novel sex chromosomes: the role of sex in shaping complex traits' (ComplexSex) targeting Horizon 2020.

assistant: **Abstract**

The origin and evolution of sexual reproduction and sex differences represents one of the major unsolved problems in evolutionary biology, and although much progress had been made both via theory and empirical research, recent data suggest that sex chromosome evolution may be more complex than previously thought. The concept of sexual antagonism (when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females) has become essential to our understanding of sex chromosome evolution. The goal of this proposal is to understand how the interacting effects of sexual antagonism, sex-linked genetic variation, and sex-specific selection shape the genetic architecture of complex traits.  I will test the hypotheses that: 1) individual sexually antagonistic loci are common in the genome, both in separate-sexed species and in hermaphrodites, and drive patterns of sexual antagonism often seen on the trait level. 2) That the response to sex-specific selection in sex-linked loci is usually due to standing sexually antagonistic genetic variation. 3) That sexually antagonistic variation is primarily non-additive in nature. To accomplish this, I will use a combination of approaches, including sex-limited experimental evolution of the X chromosome and reciprocal sex chromosome introgression among distantly related populations of Drosophila, quantitative genetic analysis and experimental evolution mimicking the creation of a novel sex chromosome in the hermaphroditic flatworm Macrostomum, and analytical and simulation modeling. This project will serve to confirm or refute the assumption that trait-level sexual antagonism reflects the contributions of many individual sexually antagonistic loci, increase our underst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of new materials by means of controlled vitrification and crystallization of inorganic wastes from urban incinerations' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The investigation here proposed is focused in order to produce glasses and glass-ceramics materials, using the wastes urban incinerators as raw material. Other raw material, such as slags and glass cullet can be employed as complementary material. The new obtained products would have, not only usefulness as material of construction, but also they could be useful in public works and decorative architectural elements. In any case, these new materials could be storage as inert forms. The waste powders, will be characterized with respect to the chemical composition, by their particle size and high temper, behavior. The glass composition may be varied with possible addition of other waste materials such as slag or glass cullet the effects of these additions will be examined. The obtained original glasses will be characterized with respect to physical, chemical and mechanical properties. The toxicity of these glasses will also be determined. Finally the capacity of the original glasses to produce glass-ceramics will be studied with different methods. The sintering behavior will be considered terms of the relationship between the densification and the initial composition and characteristics of original powder. The nucleation and crystallization behavior of the previous glasses will be investigated. Crystallization rates and active energy for nucleation and crystallization will be determined for different compositions. The obtained glass-ceramics will characterized with respect to physical, chemical and mechanical properties. The toxicity of these glass-ceramics will also determined. In conclusion, this investigation will allow the development of a new range of vitreous and glassceramics materials obtained from urban incinerators wastes, in order to eliminate the high cost and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Coordinated Research in Earth Systems and Climate: Experiments, kNowledge, Dissemination and Outreach'.

assistant: **Concept**

CRESCENDO brings together seven Earth System Modelling (ESM) groups with three Integrated Assessment Modelling teams, as well as experts in ESM evaluation, ESM projection and feedback analysis, climate impacts and science communication to address the following goals; (i) improve the process-realism and simulation-quality of European ESMs in order to increase the reliability of future Earth system projections; (ii) develop and apply a community ESM evaluation tool allowing routine ESM performance benchmarking, process-based ESM evaluation and the analysis of Earth system projections. The resulting tool will be installed and made openly-available on the Earth System Grid Federation (ESGF); (iii) further develop the discipline of emergent constraints in order to better constrain the representation of key biogeochemical and aerosol feedbacks in ESMs and thereby reduce overall uncertainty in Earth system projections; (iv) quantify the effective radiative forcing of key biogeochemical and aerosol feedbacks in ESM projections; (v) contribute to the development of a new set of combined socio-economic and climate emission scenarios that more explicitly link future socio-economic development pathways with global radiative forcing; (vi) apply the project ESMs to these new scenario data to generate an ensemble of Earth system projections for the coming century and, in combination with the underlying socio-economic scenarios, use these projections to assess joint risks and co-benefits related to climate change, climate impacts, adaptation and mitigation; (vii) ensure data produced by CRESCENDO is available to the international community through timely archival on the ESGF and work closely with climate impact assessment and regional downscaling teams to ensure maximum uptake and use
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Artificial Right-Heart without External Power from Bench-to-Bedside' (HeartWise).

assistant: **Innovation**

Addressing right ventricular (RV) failure through mechanical circulatory support remains an intricate challenge, impacting patients' overall Quality of Life. Existing solutions are hindered by exorbitant costs, intricate device setups, infection risks, limited blood flow control, and hemocompatibility. Additionally, all patients with left ventricular assist devices face the risk of chronic RV failure. Despite a substantial untapped market for adult RV failure, there remains a critical gap in clinically-approved mechanical assist devices. The HeartWise initiative aims to revolutionize RV support with a dedicated device tailored to disease and eliminating the need for external power sources or control units. HeartWise builds upon two societally viable early-stage ERC-PoC technologies initially developed for the niche yet humanitarian pediatric device market. We aim to extend their application to adult disease markets, beginning with the MENA and European regions. The project integrates these two PoC technologies: circulation support devices that operate without external power AND patient-specific customized cardiovascular surgical planning. HeartWise aims to advance a revolutionary, fully implantable MCS prototype, akin to an artificial mechanical heart, for practical clinical implementation. This disruptive innovation marks a significant departure in ventricle assist devices, as it operates autonomously within the body without reliance on external power. Offering powerless circulatory support and globally accessible interactive patient-specific hemodynamic customization through the internet, we aim to scale-up these technologies to penetrate adult cardiovascular disease markets. Notably, it addresses a substantial market, serving a significant number of adult right heart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A mechanistic in-vitro approach to risk assessment and biomonitoring of neurotoxic metals' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The overall objective of the project is to determine the role of in vitro systems as an alternative experimental approach to characterise the mode of action and molecular effects of neurotoxic metals of major environmental importance.For these studies, lead, mercury, manganese and aluminium have been selected given a large body of clinical  evidence indicating their ability to induce neurological disorders in humans. The detrimental effects of these  metals in the mammalian nervous system are also documented by a number of conventional whole-animal  investigations.  A comprehensive approach is used integrating cytotoxicity assays and mechanistic studies to identify molecular  targets and critical end-points in neural cells exposed to metals in vitro. The project includes a series of  analytical and toxicokinetic studies as well as physiological validation assays using an experimental  in vitro/ex vitro design. Neutron activation analysis, radiotracers and gel filtration techniques are used to  quantitate trace metal levels in cultured cells and to examine the role of variables (i.e., metal uptake processes,  intracellular distribution, metabolism and binding to biomolecules) as factors determining the effective metal  concentration in exposed cells. Dose/effect relationships for metal interactions with cellular targets including  neurotransmitter receptors, second messenger systems (phosphoinositide/protein kinase C, calcium signals, cyclic  nucleotides and nitric oxide pathway), gene expression, cytoskeleton, and physiological parameters of cellular  homeostasis (i.e., pH, membrane potential) are investigated. The systems used include primary cultures of cortical and cerebellar neurons, astrocytes and cell lines of neural  origin, namely rat PC12 cells and human SH-SY5