RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients' to be submitted under Horizon 2020.

assistant: **Abstract**

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease (AID) involving 0.5 to 3/1000 persons. The disease affects exocrine glands leading to dryness of the eyes and the mouth and is associated with fatigue and limb pain. In 30% to 50% of the patients, systemic and extra-glandular manifestations may develop. The spectrum of extra-glandular manifestations in pSS is broad and includes vasculitis, peripheral neuropathy, synovitis, kidney involvement and interstitial lung disease.  Moreover, pSS patients have a 10 to 20-fold higher risk of developing B cell lymphomas, conferring shorter lifetime expectancy to these patients. Whereas 10 new targeted-immunomodulatory treatments have been marketed for rheumatoid arthritis in the past 20 years, only one drug has been licensed for other systemic AIDs, such as pSS and systemic erythematous lupus in the same period. There are several factors that may hamper the development of successful drugs for AID. Being multi-organ, these AIDs are considerably heterogeneous among individuals both in terms of clinical manifestations and biological disturbances, with, as a consequence, a great difficulty to set-up accurate composite clinical end-points sensitive to change and usable in clinical trials. In this project, our objectives are:• To develop and assess sensitive clinical endpoints, for use in future clinical trials, able to evaluate response to drug treatments in patients with pSS with high disease burden and/or systemic involvement,• To identify and evaluate discriminative biomarkers for stratification of pSS patients predictive of organ involvement and disease progression and thus available for inclusion in clinical trials,• To set-up and perform an original multi-arm multi-stage clinical trial to validate the newly defined
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Single cEll guided polygeniC Risk prEdicTion of ASCVD' under Horizon Europe.

assistant: **Concept**

Atherosclerotic cardiovascular disease (ASCVD) is the most common cause of death worldwide. Aside from asymptomatic manifestations, the first sign of clinically significant ASCVD is often a severe clinical event, such as stroke or myocardial infarction. Thus, identification of people at high risk is central to battle the deadly consequences of ASCVD. The usefulness of current risk prediction models such as SCORE2 is unsatisfactory most likely since the score is built on prevalent risk factors rather than mechanistic changes occuring along the disease path. Especially, genetic risk factors acting already early in life and diverse longitudinal exposures accumulating during the lifetime of a person, lead to disturbance of gene regulatory networks which are not considered in the current risk models. In addition, the current models predict the combined risk of coronary and peripheral artery disease and ischemic stroke despite mounting evidence of ASCVD heterogeneity. To capture these missing aspects of ASCVD risk, we leverage the predictive ability of genetic variation provided to us by the world’s largest meta-analysis of GWAS for ASCVD and introduce a new disease mechanism-based stratification. In work package (WP) 1, we will map the transcriptomic and epigenetic effects of risk variants using single cell multiomics profiling of 500 human atherosclerotic tissue samples. In WP2, we infer disease associated genes, gene-gene interactions and gene regulatory networks using an innovative CRISPR-based experimental approach. In WP3, we will make use of the generated information to develop novel functionally informed polygenic risk models which are benchmarked against the conventional risk prediction models for predictive accuracy. Ultimately, this information will provide us with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Antiviral Aptamers for Treatment of HIV-1 Infection'.

assistant: **Concept**

VirApt addresses the need for novel therapeutic and prophylactic interventions against HIV-infection to limit the spread and the devastating effects of the global AIDS epidemic on societies in developing countries, and to provide therapeutic options in t he developed world as resistance to multi-drug treatment increases. In particular, the project aims to generate novel antiviral RNA aptamers that effectively inhibit entry of HIV. Aptamers are relatively short (12-30 base) single-stranded oligonucleotide s that assume defined, stable conformations and bind tightly to very specific targets. VirApt will primarily focus on aptamers that target membrane fusion, but will also endeavour to select aptamers that inhibit HIV entry at the level of receptor or co-r eceptor binding. The aptamers will be developed along three lines: as an antiviral drug, as a topical microbicide and as a basis for the design of a small molecular weight entry inhibitor. In VirApt, European expertise required to reach these goals was a ssembled, including a group experienced in aptamer isolation (Peter Stockley, Leeds), an SME that focuses on the development of antiviral therapies (Dorothee von Laer, Vision7, Hannover) and experts in structure analysis (Felix Rey, Paris). The selection of oligonucleotide aptamers is a basic and important platform technology from which products with a broad range of different applications will be developed. VirApt can help promote this crucial technology in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Neurobiological basis of collective decision making in the human brain' under Seventh Framework.

assistant: **Concept**

We continually interact with each other & share information to make decisions together as friends, families, committees, juries, interest groups and institutions. The question of how collective decisions are made dates back many centuries and has been vigorously studied in social psychology and political economics, but the biological basis of collective decision making in human brain is almost entirely unknown. This question is arguably at the heart of human society’s urgent need to communicate effectively & find better ways of arriving at global collective decisions. My research has provided new and potentially important computational models of collective decision-making based on empirical data from visual psychophysics. I propose to characterize the neurobiological basis of joint decisions by combining recent advances in economics and social cognitive neuroscience in a novel interdisciplinary research program that will ask 4 questions: (1)How do we learn to make better collective decisions? (2)What are the brain mechanisms underlying the different psychological components of collective decision making? (3)What makes some people better & some others worse at joint decisions? (4)What is the role of the neuro-modulatory hormones oxytocin & testosterone in collective decisions? I plan to develop a formal theoretical model of collective decision-making  (Q1) & use converging evidence from complementary methodologies e.g. behavioural experiments & fMRI (Q2), structural brain imaging (Q3) and neuro-pharmacology (Q4) to test & advance the model. My findings could help understand what physiological events underlie our ability to learn from experience to contribute effectively to group efforts and also disclose the biological basis that makes some of us better and some worse at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A holistic water ecosystem for digitisation of urban water sector', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

NAIADES Ecosystem envisions transforming water sector through automated and smarter water resource  management and environmental monitoring, achieving a high level of water services in both residential or commercial consumers, exploiting the efficient use of physical and digital components of water ecosystem. NAIADES will apply in various situations on diverse big data in terms of sources, data types, and entities represented that is collected by such water monitoring and control systems in Europe, including (i) the water consumption in both retail and corporation efficiency, (ii) the confidence of water consumers (including special groups as ageing, disabled persons and children), by measuring the water quality in residential buildings, offices and public infrastructures (mall, hospital), (iii) the safety and reliability through the detection of warning signs from equipment failures and maintenance report, and (iv) personalized persuasive feedback and recommendation services provided to the NAIADES App Users aiming to enhance public awareness on water consumption and usage savings, and promote user engagement in water conservation activities. NAIADES AI elements, aim to provide multidimensional intelligence on the water ecosystem by introducing: Situational Intelligence - by collecting real-time data from the buildings as they are in operation and analysing it in three different dimensions; Spatial, Temporal and Nodal; Operational intelligence - by using the power of data and its capability to extract the right information at the right time to provide insight into water infrastructure operation and improve the effectiveness of maintenance activities; Asset intelligence: the continuous data streams produced from various sub-systems in buildings will help OEMs build digi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Intention-from-MOVEment Understanding: from moving bodies to interacting minds.'.

assistant: **Concept**

From observing other people’s movements, humans make inferences that go far beyond the appearance of the observed stimuli: inferences about unobservable mental states such as goals and intentions. Although this ability is critical for successful social interaction, little is known about how – often fast and reliably – we are able to make such inferences.I.MOVE.U intends to provide the first comprehensive account of how intentions are extracted from body motion during interaction with conspecifics. Covert mental states such as intentions become visible to the extent they contribute as dynamic factors to generate the kinematics of a given action. By combining advanced methods in psychophysics and neuroscience with kinematics and virtual reality technologies, this project will study i) to what extent observers are sensitive to intention information conveyed by body movements; ii) what mechanisms and neural processes mediate the ability to extract intention from body motion; iii) how, during on-line social interaction with another agent, agents use their own actions to predict the partner’s intention. These issues will be addressed at different levels of analysis (motor, cognitive, neural) in neurotypical participants and participants with autism spectrum disorders. For the first time, to investigate real-time social interaction, full-body tracking will be combined with online generation of biological motion stimuli to obtain visual biological motion stimuli directly dependent on the actual behavior of participants.I.MOVE.U pioneers a new area of research at the intersection of motor cognition and social cognition, providing knowledge of direct scientific, clinical, and technological impact. The final outcome of the project will result in a new quantitative methodology to i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'SUstainable Novel FLexible Organic Watts Efficiently Reliable'.

assistant: **Concept**

Organic photovoltaics (OPV) represent the newest generation of technologies in solar power generation, offering the benefits of flexibility, low weight and low cost enabling the development of new consumer nomadic  applications and the long term perspective of easy deployment in Building Integrated Photo Voltaics (BIPV) and energy production farms. This is a key opportunity for the EU to further establish its innovation base in alternative energies.The current challenges reside in the combination to increase efficiencies to 8-10% (module level), increase expected lifetime up to 20 years and decrease production costs to 0.7 Eur/Wp, while taking into account the environmental impact and footprint.<br/>The key project objectives are to achieve:\tPrinted OPV with high efficiency architectures such as tandem cells  and  dedicated light management structures\tHigh performance photo active and passive (barrier) materials including process controlled morphology\tSolutions for cost effective flexible substrates, diffusion barriers and conductors\tDeep understanding of the device physics, elucidation of degradation mechanisms and estimate environmental impact of the main materials and processes<br/>The project consortium combines industrial, institutional and academic support to make a significant impact at European and International level, especially on materials and processes while demonstrating their market-relevant implementations. The industrial project partners are well assembled along the supply chain of future OPV-based products, which is an important prerequisite for the creation of significant socio-economic impact of this proposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CELL BIOLOGY OF RARE MONOGENIC NEUROLOGICAL DISORDERS INVOLVING KCNQ CHANNELS' (NEUROKCNQPATHIES) under Sixth Framework.

assistant: **Objectives**

Spontaneous mutations in three of the five known KCNQ family members are associated with rare monogenic neurological disorders including a novel rare neurological disorder linked to mental retardation. This project will focus on unravelling the cell biology underlying these disorders by identifying the processes that control KCNQ channel function, including their modulation by second messengers, biogenesis, targeting and transcriptional control. We shall identify and characterise the mode of action of new drugs that affect the function of these channels. We will analyse the biochemical and biophysical properties of the mutations associated with these disorders. Structure-function studies will unveil the processes affected, including the trafficking, membrane insertion, assembly (oligomerisation) and degradation of KCNQ channels. The transduction mechanisms underlying their regulation by neurotransmitters will be studied. By exploring protein-protein interactions, the molecular complexes that interact with these channels will be deciphered, and the physiological significance of the interactions identified and validated will be analysed. Because some mutations in the KCNQ loci do not appear to lie in the coding region, and nothing is known about the control of KCNQ gene transcription, we will study how the expression of those genes is regulated. Mouse models for some of the disorders are available for analysis in this project, and further conditional mutants will be produced to gain a more precise idea of the pathology of these diseases. Mutagenesis structure-function studies will also unveil the molecular basis for drug specificity, permitting the mechanisms of action to be defined. We have already found new drugs that modulate KCNQ channels with promising pharmacologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Multi-disciplinary risk management for stable, safe, and sustainable offshore wind-powered hydrogen production'.

assistant: **Objectives**

The WINDHY project focuses on the novel production phase of offshore wind-powered green hydrogen as a new energy solution, where the main tasks include obtaining electricity from offshore wind turbines, utilizing electrolysis to derive hydrogen from water, transferring hydrogen to a certain energy carrier, and injecting the hydrogen carrier into a designated transportation mechanism. Many new technologies are under consideration and development for this process, and each of them has own advantages and limitations, as well as varying risks to operators, communities, and the environment. The WINDHY project aims to utilize cross-industry knowledge worldwide and global evidence to understand the risky issues that threaten the stability, safety, and sustainability of offshore wind-powered hydrogen production, and integrate multi-disciplinary expertise to control and mitigate risks of the new process and value chain of offshore wind-powered hydrogen production.The WINDHY project builds a multidisciplinary consortium, with five MS/AC partners, and eight TC partners from 13 countries in all continents. It designs a staff exchange programme with 263 person-months for secondments realized in six work-packages. Through the secondments, and diverse networking activities, the project is expected to conduct a global survey in all participating countries to understand public perceptions and concerns on risky issues, interconnect knowledge about accidents in isolated databases in multiple sectors and regions, evaluates different aspects of social-, economic-, and environmental sustainability of new technologies, and develop a risk management framework with digital supporting tool for the new production equipment and process. The project follows the open science policy with a dedicated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for '8th International Conference on Flow Analysis, Warsaw 2000', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The 8th International Conference on Flow Analysis is a next venue of a series of meetings moving between continents, recognised world-wide since 1979 as the premier forum for advances in flow methods of chemical analysis, which is one of the most efficient means for mechanisation and automation of analytical procedures for environmental, industrial, agriculture and clinical applications. The scientific programme will cover all methodologies of flow analysis including continuous monitoring for process and environmental needs, flow injection analysis, primarily developed for methods requiring the use of very small quantities of samples, sophisticated reagents and miniaturised instrumentation, and its newest version - sequential injection flow analysis.Topics of scientific sessions will include theoretical aspects, the optimisation of performance of flow instrumentation and optimisation of analytical flow procedures, presentation of new developments in detection methods, biochemical detections based on enzyme sensors and immunosensing, miniaturisation of analytical flow systems. The separate session is planned for speciation and multi-detection in flow systems. Other topics include chemometrics and method for sample pre- treatment in flow conditions such as microwave digestion, dialysis, solid-phase extraction, and co-precipitation for trace analytes enrichment.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00016-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stochastic models for turbulent diffusion and large-eddy simulations of turbulent fluids flows' (1994-1998).

assistant: **Concept**

The mathematical modelling of turbulent quantities in terms of stochastic differential equations is of increasing importance for efficient flow computations in geophysical and industrial applications Using the Mori-Zwanzig projector formalism from Brownian motion theory, we formally derive exact non-Markovian Langevin models for turbulent diffusion from the Navier-Stokes equations. The first aim, the rigorous formulation of stochastic models for the atmospheric dispersion of contaminants, has almost been completed and emphasizes the fundamental Markofi approximation. Constructing a stochastic process for the Lagrangian velocities consistent with an analytic mean-field theory, unified approach will be developed to stochastic diffusion models, second-order Reynolds stress closures, and subgrid models for large-eddy simulations. Expected novel results are a theoretical derivation of the stochastic backscatter in large-eddy simulations and the explicit Reynolds-number dependence of the model coefficients. All models will be tested numerically against data from direct numerical simulations. Applications to the dispersion of hazardous contaminants, turbulent boundary layers, and combustion problems will be considered