RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design and manufacturing of smart composite panelsfor wing applications and development of structuralhealth monitoring techniques' (MACOTECH).

assistant: **Concept**

The goals of the call will be achieved by means of a “multilevel” approach, combining local damage propagation mechanisms with guided waves propagation modeling, and designing a dedicated optimization methodology aimed at finding the best actuators/sensors positioning in order to enhance the tool sensitivity to forecasted impact damages.The final results will be a numerical tool (or a family of tools) developed in high level programming language and capable of driving commercial codes (F.E. codes like MSC/NASTRAN ad LS-DYNA) within an optimization strategy. The consortium is made by two SMEs and the Department of Structural and Transportation Engineering of the University of Padova; the partners include all the needed expertise in the fields of numerical simulation (explicit and implicit F.E.) described above, as well as in the field of Structural Health Monitoring approaches based on guided waves and optimization tools. The production of GFR Panels will be supplied by external subcontracting to a primary supplier of composite structural components for aeronautical use.Within the NDE techniques special attention will be dedicated to the ‘virtual implementation’ of a novel damage detection method based on the Proper Orthogonal Decomposition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European SME-FORUM for Research and Development' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Within the framework of industry and technology related information and advisory workshops (European R+D SME-fora), the project aims to co-ordinate more concertedly and to mutual advantage the demands and interests of European small and medium-sized enterprises and research institutions, as well as their capabilities. It proposes to involve SMEs more significantly in the 5th EU Research Framework Programme (RFP) and to open up the R+D competence and infrastructure of research institutions to the SMEs.Furthermore the innovative strengths and therefore the competitiveness of these enterprises shall be increased. In tune with the 5th EU RFP, the content of the fora will concentrate on the following technological fields of application:1. information and communication technologies;2. environmental technologies and environmentally friendly energy systems.Characteristically these fields have particularly high innovation and market potential and represent a comparatively high proportion of SMEs. The project schedule is structured in such a way that, within six months the basis of a SMEs decision for its involvement in the 5th EU Research Framework Programme will be established.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification of epigenetic markers underlying increased risk of T2D in South Asians', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This project focuses on identification of epigenetic risk factors underlying the increased rates of type-2 diabetes (T2D) amongst South Asians in their home countries, migrants to Europe and other parts of the world. Known environmental and genetic factors explain only a small part of the increased risk of T2D among South Asians, who constitute the highest numbers of people with T2D worldwide.We hypothesise that epigenetic modification contributes to the increased T2D risk amongst South Asians. We will carry out an epigenome-wide scan of DNA methylation in whole blood, among T2D cases and controls from non-migrant (living in India or Pakistan) and migrant (living in the UK) South Asians. Further testing of top-ranking markers will be carried out in South Asian T2D cases and controls from UK, India, Mauritius, Pakistan, Singapore and Sri Lanka. We will use results to investigate the mechanisms underlying the epigenetic modifications identified, to develop a predictive panel of lifestyle, environmental, genetic and epigenetic markers increasing susceptibility to incident T2D in South Asians, and to quantify the contribution of these risk factors to T2D amongst South Asians in diverse regional settings.This research will improve understanding of epigenetic mechanisms underlying T2D, and may enable development of novel biomarkers and therapeutic strategies to reduce the burden of T2D amongst South Asians worldwide.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Development of a platform and toolkit for understanding interactions between nanoparticles and the living world'.

assistant: **Objectives**

We combine state-of-the-art techniques, methodologies, skills and instrumentation from several scientific arenas to create discipline-independent platforms to address key questions in nanotoxicology. Thus, we identify the routes via which nanoparticles enter and accumulate in living organisms, and connect this to representative cell-nanoparticle systems. Then using the most advanced methods of chemical, physical, biological and toxicological sciences we connect nanoparticle properties (in physiological conditions) to the mechanisms via which they interact with, and disrupt, cellular processes. We establish means and protocols via which every step of the program will be controlled, eliminating the factors that currently cause irreproducibilities. We emphasize novel unbiased assessments of intra- and inter-cellular processes after exposure to nanoparticles, enabling us to explore known, and unknown, processes.Key companies, large and small from several end-user groups, that are currently facing the challenge of applying nanotechnology in their products are built into the program in a substantial manner, and other key stake-holders are also incorporated into the overall consortium via the Advisory Board. This will ensure maximum uptake of the knowledge generated by NanoInteract, and enable development of Standards for nanoparticle risk assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biomass gasification modelling for energy systems' (1994-1998).

assistant: **Innovation**

PROJECT OBJECTIVES This project aims to develop a comprehensive macroscopic model of ligno-cellulosic biomass gasification using the circulating fluidised bed process. The proposed approach would improve the present state-of-the-art by including in the model the heterogeneous fluid-dynamics and the finite and competing kinetic rates at all stages of the CFB reactor. The main frame of the model will be gasification-oriented instead of gasifier-oriented, to maximise the flexibility and to ensure the applicability of the model to any design of CFB gasifier. The general structure will keep as open input at least: the design of the gasifier (shape and size), operating conditions (power, temperature, CFB mode, FB mode, equivalence ratio), wood fuel characteristics (kind, size, moisture). TECHNICAL APPROACH The proposed methodology consists of 3 steps: . to identify the usability of the existing CFB gasifier models and to define a consistent approach of the coupled modelling-experimentation tasks, in terms of interaction between physical experiments and mathematical simulation . to perform targeted lab- and full scale experiments enabling to write sub-models and physically founded correlations, to be included in the main frame of the model . to validate the final model by operating an industrial plant located in Zeltweg (Austria). EXPECTED ACHIEVEMENTS The resulting simulation tool would allow: . the operators of CFB gasifiers, to optimise the management of their plants by control programs based on comprehensive modelling instead of parametric or empirical approach . the manufacturers of CFB systems, to match their design to the specific applications of their customers, enabling them to produce gases of a targeted quality from various ligno-cellulosic biomass fuels (wood chips
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '1.1.1 molecular basis of blood-brain barrier permeability regulation' under Sixth Framework.

assistant: **Concept**

The blood-brain barrier controls the composition of extracellular fluid in the central nervous system and buffers against changes in the systemic circulation. The blood-brain barrier thus protects the nervous system against changes in the environment, and defects in the barrier contribute to many human disorders, including brain edema, auto-immunity and certain cases of obesity (defective leptin transport). The cells responsible for the establishment of the barrier are the brain capillary endothelial cells. Tight junctions between endothelial cells of brain capillaries are the most important structural elements of the blood-brain barrier. Two different classes of integral membrane proteins constitute the tight junction strands, occludin and members of the cl audin protein family. The molecular basis for selective permeability regulation by these proteins is however only poorly understood. Our studies will be directed towards the establishment and characterisation of an in vitro BBB model suitable for further e lucidation of molecular tight junction function. We will establish a murine BBB in vitro and address the impact of vascular locality on paracellular blood-brain barrier permeability by the preparation of brain capillary endothelial cells from anatomically distinct brain areas. Moreover, since the nature of molecular interaction between the tight junction proteins occludin and the claudins is still poorly understood, biochemical and biophysical studies will address the role of molecular interactions between these proteins in the regulation of paracellular permeabiliy, with a special emphasis on their role in anchorage to the cytoskeleton. We further propose to analyse the structural organisation of claudins within the tight junction strands, which are hypothe sized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Analysis of functional tissue motifs for precision medicine in metastatic breast cancer' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Cancer precision medicine aims to bring the right drug (or right drug combination) to the right person. To achieve this, the molecular cause of an individual’s disease must be identified and a treatment chosen that targets that cause to remedy the dysfunction. Tumors are dynamic ecosystems with high heterogeneity in tumor, immune, and stromal cell compartments. This complexity is the main obstacle to implementation of precision medicine. Consequently, approaches that rationalize and use tumor ecosystems for precision medicine are needed. To enable this, I propose to establish the concept of functional tissue motif, a multiscale network representation of multi-cellular assemblies that executes a definable set of anti-tumor or pro-tumor functional outputs. The utility of functional tissue motifs for precision medicine will be demonstrated in the context of metastatic breast cancer, which causes nearly 450,000 cancer-associated deaths each year. We will develop a highly multiplexed 3D tissue imaging approach with unprecedented throughput that provides subcellular resolution to analyze a large cohort of primary and matched metastatic tumors. We will then use viable tumor samples ex vivo to systematically perturb intra-cellular and inter-cellular network wiring using approved drugs, and the drug effects will be measured by highly multiplexed imaging. Functional tissue motifs will be identified using community and geostatistical methods and probabilistic network modeling. Analysis of functional tissue motifs in the light of the clinical data will be used to derive a novel classification system and to identify vulnerabilities in metastatic breast tumors. These vulnerabilities will be validated in follow-up experiments and in a clinical study. Given their focus on functional ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Automatic intelligent label inspection' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

SME companies have encountered problems in providing automatic inspection machines for labels used on pharmaceutical products and self adhesive postage stamps where the printed details must be 100% correct. The technical objectives of this research proposal concern the application and development of sensing devices and mechanisms that would facilitate automatic intelligent label inspection for pharmaceutical and other growing product areas. Research is required to characterise the label substrate behaviour and its effect upon label distortion and detection by relevant sensors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Promotion of footwear and components industry participation in the Sixth Framework Programme (SHOES 5000)' (2002-2006).

assistant: **Concept**

The main objective of the present proposal is to complement the FP6 instruments and to stimulate, encourage and facilitate<p>the participation of FOOTWEAR and FOOTWEAR COMPONENTS manufacturer SMEs, small research teams,<p>research centres, as well as those organisations from the Candidate Countries in the activities of the priority thematic areas<p>related, in Integrated Projects (IPs) and Networks of Excellence (NoEs). The specific objectives of this ETI proposal are:<p>The stimulation of technological innovation by supporting   activities concerning the gathering, analysis and<p>dissemination of information on S&T developments, applications and markets<p>The participation of SMEs/SME Groupings in FP6, particularly in Integrated Projects and Networks of Excellence<p>of potential interest for the shoe and auxiliary industry.<p>The activities would be (initially) mainly related to Priority 3 objectives NMP-2002-3.4.3.1-3 - The creation of knowledge<p>communities ands Priority 2 objectives IST-2002-2.3.3.1 - Products and service engineering 2010".<p>The European footwear industry lacks today competitiveness to bring its manufacturing position in the EU in balance with<p>its fashion influence around the world. Europe as a manufacturing cluster looses attractiveness. The industry keeps a world<p>influence but this kind of industry needs an IP to support a breakthrough strategy for its future. SMES are the main actors<p>of the European Shoe Industry and need to participate under different mechanisms to undertake the results of IPs and to<p>provide feedback to NoE, orienting long-term research towards specific needs.<p>The project measurable objectives are:<p>Number of Technology audits: 100<p>SMEs incorporated to IPs: 100<p>Number of Take-up actions implemented: 10<p>Financi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generalized Maps for the Analysis of 3D Shapes and Shape Collections' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In recent years there has been a considerable growth in the prevalence of digital 3D content. With applications in medical imaging, architecture, industrial design, entertainment and education, to mention just a few, there is a growing need for methodologies for scientific analysis of 3D data. In this project we will focus on an important problem which facilitates such analysis – creating informative, structure-preserving maps between 3D shapes. In many applications we are presented with a collection of related shapes, such as humans, animals, etc., and we need a way to map the shapes to each other. Such maps take all shapes to the same “common ground”, allowing the use of standard mathematical machinery for further analysis. Mapping between 3D shapes has been an active research area recently, however two aspects of this problem have not been thoroughly addressed. First, many existing methods assume little variability between the mapped shapes, an assumption which is not valid for most shape collections and might yield erroneous mappings. Second, almost all methods consider only maps between two shapes, disregarding the contextual information one can gain from investigating the collection of shapes as a whole. To address these shortcomings, we propose to design and investigate alternative map representations, namely generalized maps, which broaden the definition of maps between shapes. Our main objectives are to formulate the required design goals for generalized maps which address the shortcomings of existing methods, and to investigate one such specific representation based on a probabilistic formulation of the mapping problem. Combining the experience gained by the applicant during her postdoctoral period with the expertise in related fields provided by the host inst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Re-thinking Judaism’s Encounter with the Roman Empire: Rome’s Political and Religious Challenge to Israel and its Impact on Judaism (2nd Century BCE – 7th Century CE)'.

assistant: **Innovation**

Scholars have studied the history of the relationship between Rome and the Jewish people in Antiquity from many angles; however, they have focused mainly on the political and military confrontation between the two. Recently, scholarship has turned to a new research agenda less focused on conflict: the examination of the Romanness of the Jews who lived in the Roman empire, and, in particular, that of the Palestinian Rabbis. While this new trend is both welcome and necessary in order to balance previous approaches, it still leaves an essential question unanswered, perhaps the great impensé of the encounter between Jews and Romans. Beyond Roman concrete political decisions concerning Jews, and the Jews’ adoption of Roman cultural features such as baths, how did Roman imperialism affect the ways Judaism – both rabbinic and non-rabbinic – defined itself?This project shall answer this question by analyzing an overlooked dimension of the problem. It will examine how Roman imperialism challenged Judaism both religiously and politically because of the rivalry – from the Jewish perspective – between Jewish and Roman universalisms and “messianic” ideals. This analysis shall make it possible to assess how the Jewish encounter with Rome contributed to shaping Judaism itself, in particular regarding sensitive issues such as the integration of non-Jews in Jewish society, the Jews’ conception of Jewish Law as a national and/or universal law, and Israel’s role in the establishment of a just universal political order. Moreover, in order to better comprehend the specificity of the Jewish responses to Rome, this study shall compare them to those of the Greeks and other peoples dominated by Rome, as well as to those of the Christians until the beginning of the fourth century CE. Finally, it