RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Effects of early programming on child's neurodevelopmental outcomes' (NUTRIOMICS).

assistant: **Concept**

Diet plays an important role on the effects of neurodevelopment and there is evidence that early nutrition can influence later neurodevelopmental outcomes. Folate and polyunsaturated fatty acids, nutrients obtained via diet, are considered of extreme importance for neurodevelopment. However, the current knowledge on this field is largely based on animal, retrospective, short-term nutritional intervention studies in humans, and the scarce randomised control studies performed in humans provide controversial results. A multi-centre well-designed project of the long-term effects of early nutrition on child’s health is needed.Another important factor in child’s development is the effect of maternal metabolic pathologies, particularly obesity, on child’s early programming. Obese women are frequently deficient in fatty acids and folates during pregnancy, nevertheless there are only few studies on maternal BMI and its effects on nutrional status. It is not known to what extent BMI influences early programming.The current project aims to study the short and long-term effects of early programming (maternal supplementation during pregnancy and maternal obesity) together with polymorphisms in fatty acid and folate metabolism on maternal metabolomics during pregnancy and infant’s transcriptomic and epigenomic profiles at delivery in association with child’s neurodevelopmental outcomes.The current project would enable to establish positive dietary and body weight recommendations for women planning pregnancy and for pregnant women, which could be of broad social significance in terms of affecting health behaviours, education, work potential and mental illness in every age group. Further, the general concept that early programming might program long-term health has potentially far-reac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pietro Bembo's soundscape: a musical tour in the early modern Italian peninsula' (BEMUS) under Horizon 2020.

assistant: **Objectives**

The Venetian humanist Pietro Bembo (1470-1547) played a central role in the European Renaissance. His literary works are widely known and his rich epistolary attests both his contacts with all the most important figures of his time, and the variety of his interests, ranging from literature to arts. However, a missing piece precludes the possibility of grasping Pietro Bembo's multi-faceted figure in its complexity: the sound dimension in which he was immersed has never been adequately investigated so far. This project aims to complete Bembo's portrait by reconstructing the soundscape that surrounded him, and his musical interests and networks. His literary works and letters, together with a few dedications in printed musical volumes and letters written by his friends and acquaintances, offer precious material in order to understand his involvement with music. The research will also explore the reception of his poems by composers who set them to music, investigating the reasons of this choice and evaluating Bembo's role in the dissemination of his texts among musicians. All the collected data, read against previous musicological studies about the cities where Bembo lived and the musicians working there at the same time, will contribute to complete Bembo's image from a musical point of view. The main results of the research will converge in a multimedia database which, combining the images of the very places that Bembo frequented and the music he could have heard, will constitute a visual and aural reconstruction of Bembo’s experiences of five centuries ago.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy Efficient FPGA Accelerators for Graph Analytics Applications' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

It is reported that data centers today consume up to 3 percent of the global electricity usage. This is expected to increase in the upcoming years as the amount of data processed in the cloud increases substantially. An effective way for data centers to achieve better performance and energy efficiency is to perform computation on specialized processing elements. Field programmable gate arrays (FPGAs) enable customization of logic after manufacturing to achieve better energy efficiency compared to general purpose processors. Today, prominent hardware and software companies are investing in data center solutions that integrate FPGAs with CPUs, and significant energy consumption and performance improvements have been demonstrated for several data center applications. However, the main barrier for wide spread adoption of FGPAs in data centers is the cost of programming, which typically requires months of development time by hardware designers. This makes it unaffordable for small-to-medium software companies to effectively utilize the available FPGAs. The purpose of this project is to lower this barrier for emerging graph analytics applications for knowledge discovery and machine learning. The basic idea is to use an abstract interface that allows a domain expert to describe an application as a set of serial functions defined per vertex and/or edge. We propose a customizable implementation template that automatically maps the abstract user functions to massively parallel FPGA implementations. The proposed template will hide from users many low level implementation details such as parallelization, pipelining, synchronization, memory access optimization, race and deadlock avoidance, etc. This will help bridge the gap between high level application descriptions and costly hard
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computational Photochemistry in the Long Timescale: Sub-ns Photoprocesses in DNA' (SubNano).

assistant: **Innovation**

My goal in the SubNano project is to massively speed up the dynamics simulation of photoexcited molecules to allow addressing sub-nanosecond phenomena (that is, one thousand times above the current limits). The sub-ns methodology will be employed to investigate the long timescale nonadiabatic dynamics of photoinduced processes in nucleic acids, including DNA photostabilization via excitonic processes, biological fluorescent markers, and transient anion formation in DNA repair.To fulfill these goals, I will develop and implement a series of methods to extend nonadiabatic dynamics simulations into the new timescale, mainly based on a novel adaptive diabatic machine learning algorithm and a novel zero-point-corrected and vibronically-corrected mixed quantum-classical method.The sub-ns methodology will be constrained to be general (any kind or size of molecule), black-box (minimum user intervention), modular (adaptable to any electronic structure theory), on-the-fly (no need of precomputed potential energy surfaces), and local (independent-trajectories).It will be implemented into the Newton-X software platform, which I have been the main designer and developer. It will also be made available for all academic community through new releases of Newton-X.For the last 25 years, theoretical investigations of photodynamical processes have been restricted to the ultrafast (picosecond) regime, selectively choosing problems in this domain. The extension into the sub-ns regime is finally feasible thanks to a large algorithmic infrastructure I have built over the last 13 years, paving the grounds to develop a new research area, atomistic nonadiabatic dynamics on the long timescale.The success of the SubNano project will have an enormous impact on the research field, allowing to invest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tracking Elephants: Mapping pre-colonial African ivory trade networks using Bioarchaeological techniques' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

TEMBo will map the flow of ivory from archaeological sites in eastern and southern Africa over the past two millennia by training the researcher in a range of bioarchaeological techniques to identify (ZooMS, FTIR) and source (isotope analysis) archaeological ivory artefacts. This information will significantly improve the understanding of regional interactions between coastal points of export and inland communities supplying the ivory for this trade by reconstructing wider Indian Ocean trade networks between some of the most important pre-colonial African states. TEMBo will thus benefit from an outgoing phase where the researcher is based at the University of Cape Town, South Africa in order to obtain access to the ivory material, as well as be trained by world-leading experts in both archaeological ivory analysis and modern elephant ecology, and benefit from knowledge exchange between the archaeologists working on these sites.  Though the project is archaeological, the isotope data will have an impact on modern wildlife conservation by extending the existing database of isotopic signatures characterising elephants from different parks and wildlife sanctuaries across southern Africa.  Finally, TEMBo will train the researcher in spatial analyst and mapping database software (ArcGIS) to create an online, open-source database of African ivory, and will work with collaborators of TEMBo from different disciplines (archaeology, ecology, conservation, heritage) in utilising this data in a way that is suitable and useful for education, training, and outreach to the public.  Thus, a core part of TEMBo will be to train the researcher in outreach and dissemination of interdisciplinary data in a way that is relevant, timely, and educational for a wide range of audiences in Europe a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Solving the tangled ontogenesis of the stem for sustainable crops', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Crop yield depends in a large part on stem height and inflorescence structure. Mutations that reduce stem growth have been used widely to improve crop yields but also have undesired side effects, for example during seed formation. In spite of its importance, stem development is poorly understood. Fundamental knowledge of how genes control stem growth is required to develop more precise genetic tools to increase plant productivity by modifying plant height and shape.The ARABIDOPSIS THALIANA HOMEOBOX1 (ATH1) gene inhibits stem development but is rapidly downregulated prior to the floral transition to allow elongation of the inflorescence stem. Data from the host lab indicate that ATH1 integrates two of the key hormonal signals that control stem growth: gibberellin (GA) and brassinosteroid (BR). My objectives are to reveal the mode of action of ATH1 and use this knowledge to develop new ways of modifying plant height with fewer undesired side-effects. I will reveal how ATH1 influences GA and BR signalling, understand molecular mechanisms of ATH1 action and identify cis-regulatory mutations that result in dwarf plants due to persistent ATH1 expression after flowering. Such mutations would be particularly useful for two reasons: first, regulatory mutations have been selected repeatedly in evolution and crop improvement because they allow subtle changes in gene expression, with fewer pleiotropic effects. Second, this type of mutation would be expected to be dominant and especially useful in polyploid crops.In addition to addressing a fundamental problem with practical use, this work will give me cutting edge training in plant developmental genetics and quantitative phenotyping at cellular and macroscopic levels. At the same time, the project will benefit from my knowledge of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microsystem integration based on electroactive polymer gels for cardiovascular applications' (Heart-e-Gel).

assistant: **Concept**

Actuators based on electroactive polymer (EAP) hydrogels constitute a very attractive yet poorly explored technology. EAP hydrogels can expand and contract by several times their original volume by application of a small voltage. They can be engineered to be either porous or non-porous and the pore density and distribution can also be controlled. Their inherent limitations of very low actuation speed and need to operate in an aqueous medium constitute no impediment – and in fact make them particularly suitable – to a host of medical applications, some of them with high economic and societal relevance.<br/>The Heart-e-Gel project utilises a microsystem concept based on electrode activation to change the volume of EAP hydrogels designed for operation in the cardiovascular system. Given the soft and aqueous nature of these gels and considering the need to accommodate for large volume changes, integrating these materials into complete microsystems poses unique challenges in terms of heterogeneous integration.<br/>Heart-e-Gel proposes to target specific medical applications and will require modelling of the microsystem-medical interface as well as assessing the potential of different material, actuation, volume sensing, and system delivery options. Three types of systems of immediate interest in cardiovascular surgery have been selected:  a generic occluder for vascular repair, a system for improving endografts/stents for the treatment of abdominal aortic aneurysms, and an adaptable band around the pulmonary artery for patients with congenital heart diseases, or with arteriovenous fistulas.<br/>While carrying out the systematic study of EAP hydrogel integration into microsystems, substantial information on processing and characterisation will be gathered and will ultimately
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Towards a non-critical non-AdS/non-CFT correspondence' under Sixth Framework.

assistant: **Concept**

In the last few years many important successes have been achieved in the understanding of string theory and its relation to large N gauge theories. The AdS-CFT proposal is the best understood example of such holographic dualities. Since its original propos al, many steps have been taken to extend this duality and build the string theory dual of (large N) QCD, but a satisfactory and complete model is still a long way to come. It is plausible that the dual of QCD involves a non-critical five-dimensional string theory. Compared to critical ten-dimensional theories, not much is known about non-critical strings, and only recently the extension of AdS-CFT to the non-critical case has been considered. The aim of the present project is to gain a deeper understanding in the duality between non-critical strings and four-dimensional gauge theories. Studying non-critical AdS-CFT will require understanding the way non-critical string theory behaves in the presence of background RR fluxes. This is an essential feature of al l dual string theories because D-branes (which sustain gauge and flavor degrees of freedom) are sources for RR-fields. Moreover, non-critical AdS-CFT will have to deal with stringy effects since the characteristic size of the backgrounds involved is of the same order as the string length. To this purpose, it will be very interesting to use the duality and known results on superconformal gauge theories to gain insights into string dynamics. We will also consider the breaking of the field theory conformal inv ariance: while at a first stage this symmetry proves to be very useful to constrain the dynamics of the system under consideration, QCD is not conformally invariant. In particular we will be interested in the effect on the string background, of D-branes ca rryi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Discovering how polycomb domains form and function in gene regulation'.

assistant: **Innovation**

Polycomb group chromatin modifying systems are essential for normal gene regulation and development, and alterations in their activity are a hallmark of a broad range of cancers. Although the chromatin modifications placed by the two central polycomb protein complexes (PRC1 and PRC2) are well-characterized, how this fascinating system selects its target sites in vivo, and then forms polycomb chromatin domains that are repressive to transcription remains enigmatic. This constitutes the major conceptual gap in our understanding of this essential gene regulatory system. We recently discovered a new pathway that is sufficient in model systems to initiate polycomb chromatin domain formation. Building on this discovery, an ambitious high-risk/high-reward yet hypothesis-driven multidisciplinary approach integrating biochemical, molecular, genomic, and single-cell analyses will be exploited to discover the fundamental principles that underpin polycomb domain formation and subsequently transcriptional repression. Specifically, the three aims of the research programme are to: (i) Discover how the KDM2B/PRC1 complex initiates polycomb domain formation, (ii) Discover how polycomb target sites are selected and polycomb domains formed during normal cell lineage commitment, and (iii) Discover how polycomb domains regulate gene expression. Going well beyond the state-of-the-art, our innovative approaches will lead to major new breakthroughs closing the conceptual gap that currently limits our understanding of how polycomb complexes regulate gene expression, an essential first step towards the possibility of devising strategies for therapeutic intervention in human cancers and other diseases where these systems are perturbed. Furthermore, support from the ERC in tackling these important
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Water-mass transformation and Pathways In The Weddell Sea: uncovering the dynamics of a global climate chokepoint from In-situ measurements' under Horizon 2020.

assistant: **Concept**

Deep water formed around the Antarctic continent drives the world ocean circulation. 50-70% of this deep water is formed within only about 10% of the Antarctic circumpolar band: the Weddell Sea. Subtle changes in the circulation of the Weddell Sea can lead to major changes in floating ice-shelves, with critical implications for global sea-level, the production of deep water and the global ocean overturning circulation. Despite these critical climate implications, the Antarctic shelf circulation remains poorly understood. I propose an ambitious project at the crossroads of experimental and numerical oceanography. By drawing on the strengths of each discipline I will explore the regional water-mass pathways in the Weddell Sea: an unchartered cornerstone for understanding the polar ocean circulation and its links to global climate. A key issue facing climate scientists will be addressed: “What sets the tridimensional water-mass structure and pathways in the Weddell Sea and modulates the flow of deep waters between the Antarctica ice-shelves and the global ocean circulation?”To address this question I propose to investigate several key aspects of the Weddell Sea system: the dynamical forcing of the Weddell gyre and its response to atmospheric variability; the forcing and the circulation on the continental shelf and its interaction with the gyre; and the time-scale and mixing associated with bottom water sinking along the continental shelf. WAPITI approaches these objectives through a series of innovations, including (i) an ambitious field experiment to investigate the shelf circulation and processes, (ii) a powerful conceptual framework applied for the first time to a realistic eddy-resolving model of the Weddell gyre, and (iii) a novel instrument that will be developed to