RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Epithelial/Mesenchymal Cross-talk in response to injury and early tumorigenesis; a spatiotemporal perspective' to be submitted under Horizon 2020.

assistant: **Abstract**

Epithelial tissues have evolutionarily adapted to rapidly react to tissue disruption in order to restore the epithelial barrier and ensure survival. The dynamic behaviour of epithelial cells in response to injury represents a decisive mechanism to recover tissue integrity. Following injury, not only cycling but also differentiating epithelial cells are able to revert back, reacquiring stem cell-like behaviour and contributing to tissue regeneration. Although this cellular plasticity is normally a strictly controlled and limited process, if inadequately activated in cells with pre-existing tumour-initiating mutations it will have implications for cancer development.In this proposal, I will investigate the little-known mechanisms governing the dynamic changes in epithelial cell behaviour in the events after tissue injury using the uncomplicated architecture of the oesophagus as a model. The aim is to identify molecular regulators governing cell fate switching following the early wound response, and ultimately, reveal their potential relevance for early epithelial tumour formation. Given the increasing relevance of the mesenchymal compartment both in tissue maintenance and disease, I will particularly focus on the contribution of epithelial-mesenchymal cross-talk in the regulation of epithelial fate changes. To this end, I present an innovative approach that combines precise lineage tracing cell fate data with spatiotemporal single-cell whole transcriptomics. This approach relies on cutting-edge techniques and transgenic animal models widely established in the host laboratory that, when combined, will enable the identification of rules regulating behaviour of epithelial cells with temporal and spatial resolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Additive Manufacturing for Wear and Corrosion Applications'.

assistant: **Objectives**

AMCOR will develop and demonstrate Laser Metal Deposition (LMD) industrial manufacturing systems for the deposition of functional graded coatings (FGM) and 3D features onto metallic components supplied by industry that are subjected to in-service wear and corrosion. This will be supported by the development, production and testing of mixed powder combinations for coatings suitability.The proposed system will combine LMD, robotic and CNC positioning, modelling, 3D scanning techniques and sensors to give a ‘turn-key’ solution to the deposition of multiple materials for quality controlled FGM coatings and 3D features onto original manufactured components and repair surfaces. The solution will offer a knowledge driven manufacturing process with significant production benefits; automation, self-management and reduced material usage and waste.The integrated system will be assessed for its cost effectiveness, in terms of manufacturing efficiency and consumption of raw materials, but also its application flexibility for exploitation into industry sectors not represented in the consortium. This will be addressed by developing the following topics:•Automation - Intelligible software interface for automated manufacturing by LMD.•Production efficiency - Integrated process incorporating component referencing, in-line monitoring, closed loop control and NDT inspection.•Materials – Intuitive database of material combinations with selection focused on coatings performance.•Qualification - Demonstrator parts from industry (mining, automotive, power generation, tooling, industrial drives) validated by AMCOR end-users. Development of QA/QC deposition procedures.To achieve these key objectives, the consortium consists of 16 organisations who are recognised leaders in various industrial sec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discovery of new chemical families active on biochemical fungicidal targets' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content I Discovery of new chemical families active on biochemical fungicidal targets > To implement a new methodology that could provide new chemical leads in the area of biochemically active compounds by identifying the pharmacophoresknown fungicides and searching for 3D (three dimensions) analogs : 1- Choosing the organic fungicides (up to 4) we want to study (known mode of action). 2- Designing, synthesising and the biochemical testing of structural parts of the molecule to identify the pharmacophore (20 months). 3- 3D modelling of the pharmacophore. 4- Retrieving analogs of this phammacophore in 3D-databases and the screening of these analogs (3 months for the last two parts). The expected benefits are to get bioactive compounds that present better performances than the known compounds i.e. better biological efficacy, better toxicological and/or environmental profile, lower cost... Although 3D analogy approach exists for the discovery of new drugs and was validated in the pharmaceutical industry (see as examples of recent reports 1. Med. Chem. 1995, 38, 3351 and 3566), this approach is novel in the agrochemical field'. Training content (objective, benefit and expected impact) > To participate to an applied research project inside a high-level industrial environment > To increase my knowledge in organic chemistry and biochemistry by working on various types of chemistry appliec io biochemical efficacy. > To leam basic techniques of 3D molecular modelling on the best cquipment available. Links with industry /industrial relevance (22) I will be hosted in an Industrial Research Laboratory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Potentials of low-external input and sustainable agriculture to attain productive and sustainable land use in Kenya and Uganda' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

* Study the sustainability and economic performance of LEISA farming practices in low and high agricultural potential areas of Kenya and Uganda.* Determine potentials of LEISA in relation to Integrated Nutrient Management (INM) and to increase agricultural sustainability and productivity in Kenya and Uganda.* Formulation of adoption strategy of LEISA farming techniques.* Dissemination and facilitating implementation of research results to relevant actors like farmers, extension services and NGOs, research institutions and policy makers.* The project addresses the production systems in an integrated way (in an agronomic, social and economical and environmental context) and is explicitly aiming at appropriate and relevant improvements in the productivity taking into account long-term production and environmental effects.Expected OutcomeThe following concrete outputs are planned:* comprehensive research reports on the potentials of LEISA farming in developing sustainable agriculture in Kenya and Uganda;* two articles in international scientific journals;* articles in popular national and international journals;* extension materials in the form of a database of nutrient flows, a simple nutrient flow decision support model, leaflets;* 4 extension/NGO workshops, directed at implementation of the recommendations resulting form research findings;* 2 policymakers workshops directed at implementation of the recommendations resulting form research findings.* Measurement of nutrient balances and economic performance at farm household level under LEISA and conventional management through monthly monitoring, measurements and application of formulated frameworks for analysis (nutrient monitoring model, economic model and farm household assessment).* Impact assessment of selected LEISA
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Conceptualizing representative democracy in the EU polity by re-thinking classical key conceptual clusters for the EU multi-level polity' in the context of a Seventh Framework call.

assistant: **Objectives**

Aims of the research project: The interdisciplinary project aims at a thematic set of post-Habilitation studies of the applicant in co-operation with senior scholars from the host institute. More specifically, the aims are 1) To sketch a conceptual framework for representative democracy in the European Union developed in a broad historical perspective of political thought and conceptual change through the analysis of key texts of classical and modern political thinking. The conceptual framework is constructed around three key conceptual clusters (state-government-policy-polity; parliament-representation-politicians; citizens-subjects) as thematic perspectives. There clusters are both challenged by European integration and discussed in the debates on the character of the EU. 2) To extend the methodological insights of conceptual history on the contingent and controversial character of political concepts to past and present debates on the EU as a changing polity 3) To establish a disciplinary link between conceptual history, Democratisation studies and European integration studies, supported by insights from constitutional law, philosophy, history and linguistics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Influence of delays on the models of angiogenesis process and immunotherapy of cancer'.

assistant: **Concept**

Tumour growth, dynamics and interactions with an immune system are very important processes from medical point of view and can be also considered as a topic of mathematical modelling and analysis. We would like to focus on the models of tumour angiogenesis process and immunotherapy of cancer known from the literature and study the influence of time delays on the dynamics of these models solutions. It is well-known that the signaling pathways can be modelled using time delays. Therefore, the models described by systems of ordinary differential equations can be modified to the systems of delay differential equations. Such modifications have been considered for example in the case of Hahnfeldt et al. model of angiogenesis process which is the most accepted model of this process. Immune processes are also considered as delayed with respect to the stimuli. The first model which reflects this effect was proposed by G.I. Marchuk (1980). At present there arises many models describing different aspects of anti-tumour immunity and immunotherapy of cancer. Within the project we will study the influence of time delays on the dynamics of solutions to mathematical systems of differential equations describing tumour angiogenesis and immunotherapy of cancer focusing on the models with at least two delays. From the mathematical point of view the dynamics of systems with several delays is not as well-known as in the case of one discrete delay and such analysis is a challenging problem and can bring also some insight to the medical knowledge and treatment of cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Flexible coil winding technology' in the context of a Fourth Framework call.

assistant: **Objectives**

The specific industrial objective of this cooperative research project is to design, develop and demonstrate a highly flexible, generic manufacturing technology related to the production of electrical coils of all types that offers significant productivity benefits over contemporary equipment supplied from, and used by, competitors outside the European Union. This will be achieved through the fulfilment of technical objectives relating to : - a cognitive, micro-mechanical, adaptive mechatronic coil winding head providing increased speed of production of coils of various types - better handling and more accurate placement of very flexible and finely insulated electrical wires using an on-line vision system giving better consistency and quality of machine output - simpler, faster, menu-driven machine set-up procedures enabling semi-skilled operators to quickly re-configure the cognitive winding head assembly to cater for the rapidly changing demand in coil varieties from coil users - higher levels of machine integration and functionality at lower capital and running cost - higher machine reliability with lower service and maintenance costs These objectives will be achieved by combining proven state-of-the-art" vision systems technology with novel mechatronic actuation and wire handling methods to create (with further post-project development) a new, industrially exploitable technology applicable throughout the coil winding and other related manufacturing industries."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A revolutionary new orthotics service—consultation to delivery in less than a week.'.

assistant: **Innovation**

The number of Europeans with paralysis, deformity or orthopaedic impairments that use orthotics will reach 9.6 million by theyear 2020. Orthotics is a speciality involving the application of external devices to the body to support and improve posture,function and mobility, and manage pain and deformity. The majority of people requiring orthotics are over 50 years old;demand is expected to increase with the ageing population and the rising prevalence of obesity, cardiovascular disease,diabetes and stroke, where foot complications and reduced mobility are commonplace.Approaches to orthotics have not changed in over 50 years. The process takes up to 12 months, and requires technicians,physiotherapists, orthotists and manufacturers. Often, by the time patient receives their orthotic their condition hasdeteriorated or the orthotic no longer fits, resulting in ineffective treatment, repeat visits, poorer clinical outcomes, and higherrisk of surgery.Families all over Europe are being failed by this service. In order to tackle this challenge, we have developed a streamlinedorthotic 3D scanning, design and printing service. Our orthotic service is the only service in the world capable of deliveringan effective custom orthotic within 1 week of consultation. Our pathway is faster and more cost effective than traditionalmethods.We use a multidisciplinary team, CAD and FEA to optimise design, add strength and flexibility and reduce unwantedmovement, resulting in better patient reported outcomes and quality of life. Our key innovation is the overarching technologyand software that links together the entire service pathway, from consultation to delivery in under a week.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Atmospheric WAter Cycle over Antarctica: Past, Present and Future' (AWACA).

assistant: **Innovation**

Climate models predict that precipitation will increase in Antarctica, which will moderate global sea-level rise. Meanwhile, the isotopic composition of snowfall records climate parameters which can be recovered in ice cores. However, there are still major gaps in our understanding of the atmospheric water cycle over Antarctica. For the first time, the AWACA project will provide a consistent and comprehensive combined observation and modeling framework to understand and predict the fate of atmospheric water all along the tropospheric column. Specifically adapted/designed instruments will be combined to form observation platforms deployed at 5 sites along a 1100 km coast-to-plateau transect aligned with the typical moisture-carrying air mass trajectories. The challenges of working in full autonomy in Antarctica, never addressed to such an extent before, will be tackled by collaborating with experts in polar technology and logistics. The resulting data set will make possible the study of the processes driving the water fluxes and composition to an unprecedented level, and the gained insights will be a strong basis to develop new physics parameterizations for regional and climate models. Once validated along the transect but also in other regions of Antarctica thanks to satellite observations and past campaigns, those models will enable us to decipher the past and future variability of the atmospheric water cycle over Antarctica.


**Keywords:** Remote sensing ; paleoclimatology ; climate projection ; cloud and precipitation observation and microphysics  ; water vapor ; Antarctica ; Surface flux ; blowing snow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Control policy optimisation for SARS and other emerging infections: characterising transmission dynamics and estimating key epidemiological parameters' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposal has four key objectives: a) to characterise and quantify the key factors that determine the transmission dynamics of the aetiological agent via epidemiological analysis and clinical studies of material collected from SARS patients, to develop statistical methods to estimate key parameters, and to complete retrospective epidemiological analyses of national or city based databases of the SARS epidemics in Hong Kong, Beijing, and Taiwan that capture the spatial and temporal network structure of mixing between individuals; b) to define ideal structures for case databases to facilitate rapid analysis and interpretation of epidemic trends and the impact of interventions; c) to create a mathematical framework for studying optimal control policies for directly transmitted respiratory tract infectious diseases in both local, country-wide and global contexts, to inform policy makers; d) to develop models for scenario and risk analysis to explore how best to control defined infectious disease epidemics. The proposal builds on past work with collaborators in Hong Kong which facilitated the creation of a structured database for all SARS cases in those regions and Taiwan, and the analysis day by day of the course of the epidemic and the impact of different interventions (Riley et al, Science May 23rd, 2003; Donnelly et al., Lancet, May 7th, 2003). Clinical aspects to be addressed in this proposal include: the typical course of infection in patients of different ages and with various co-morbidities; the infectiousness (level of viral shedding) of patients through time following acquisition of infection; and the distributions of incubation and infectious periods as a function of modifying factors such as age. Epidemiological aspects include the routes of transmission of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Eocene and Cretaceous Oceanography: Disentangling the roles of geography and temperature on deep ocean circulation in past greenhouse climates', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Ocean circulation plays a dominant role in distributing heat over the planet and in providing oxygen for life in the deep sea. The thermohaline circulation will likely be affected by global warming, in particular the current areas of deep water formation at high latitudes. The thermal maxima of the Cretaceous (94 million years ago) and the Eocene (51 million years ago) are the two most important greenhouse climate phases of the last 100 million years and are seen as analogues to current climate change. For the Cretaceous and Eocene, mechanisms of deep-water formation and the role of ocean circulation on heat transport are poorly understood. This research aims to disentangle the controls of geography and temperature on deep circulation in past greenhouse worlds to identify ocean circulation dynamics fundamental to climates warmer than the present-day. This research has a three-fold approach:1)  To generate neodymium isotope signatures from a range of sites in the Southern Ocean to identify and track deep-water masses under two different circulation regimes: - the opening of gateways in the Eocene and - an episode of sudden warming in the mid-Cretaceous, which led to a widespread lack of oxygen in the world's oceans. 2) To identify the source regions of deep water formation, the geochemical signatures (neodymium isotopes, rare earth elements, mineralogy) of past seawater and detrital sediment contributions will be compared and contrasted to reconstructions of paleotopography.3) To test scenarios of modelled ocean circulation in past greenhouse worlds, the Nd-isotope data will be integrated with coupled ocean-atmosphere climate models.The candidate will develop new competencies in geochemical techniques and climate modelling. Broadening her scientific skills base, whilst t