RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New design principles fostering safety, agility and resilience for ATM' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Air Transport in general and the Air Traffic Management system are formed by a high number of elements, human, organisational and technological, that interact with each other creating a unique system of intrinsic complexity. The variability of the initial conditions and the high number of potential scenarios makes the system performance particularly difficult to predict. As a consequence, the propagation of perturbations and disruption, and the understanding of the allocation of resources needed to mitigate those undesired phenomena, represent a major challenge in today system design.Technological and procedural solutions are being investigated in a number of research projects, but the adaptability of the system to perturbations has proven a demanding research topic that Europe needs to address to understand the how to build a future operational concept resistant to these undesired events.There is no definition of resilience in air transport yet and therefore there are no unique metrics for it. Potentially, different metrics take into account different aspects of the resilience of the system. Therefore it is important to develop metrics quantifying the level of resilience of the system and the likelihood of an (undesired) emergent phenomenon to propagate throughout the system without an exact understanding of the different mechanisms to mitigate it.The Resilience2050.eu proposal presents a research project that leans on the analysis of the resilience concepts, analyses the current system behaviour focusing on the propagation of undesired events and builds the future ATM concept designed to adapt to disruptions and perturbations, providing a methodology to address the resilience of the system, including a solid quantitative assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Orientation of Carbon Nanotubes in Polymer Composites'.

assistant: **Innovation**

Proposal plans to prepare well-aligned carbon nanotube (CNT)/polymer composites. The orientation of CNTs will be reached by two ways. By the first way, well-dispersed surface modified CNTs in gel network will be uniaxially stretched and then cross-linked further, to freeze to the oriented system. By the second way, CNTs with photo-active groups at surface will create self-assembled structures in polymer matrix. For this reason, it is necessary to perform surface modification of CNTs. It will be achieved by introducing of functional groups or oligomers miscible with polymer matrix to reach the best compatibility or by introducing the photo-active groups. Author believes that during self-assembly process of photo-active groups attached at nanotube surface they will induce the orientation of CNTs by light. Similar procedure with photo-active groups can be use in case of alignment by uniaxial stretching. For fixation of anisotropy after stretching the photo-active groups can be used again when oriented structure of CNTs is fixed by photocoupling and/or photocrosslinking at different stage of uniaxial stretching. The photocoupling or photocrosslinking produces strong chemical bonds that fix the internal structure of filler inside matrix. In addition the alignment can be affected by concentration of photo-active groups or used light. An influence of various wavelength, irradiation dose and type of polymer matrix on the orientation of CNTs and influence on mechanical and electrical properties of final CNT/polymer composite will be studied. Various optical, mechanical and electrical methods will be used for characterization of prepared composites. All data will be collected at various irradiation doses in order to be able to determine the photo-actuation behavior of composites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dynamic Structural Corporate Finance: Linking Theory and Empirical Testing' to be submitted under Seventh Framework.

assistant: **Abstract**

There are three components to this project: Theory; Empirical Testing; and Dissemination. All components are linked to the current policy question of how taxes influence debt and systemic risk, and all use novel dynamic structural models. I am unique in explicitly linking such models to empirical testing.Theory: “Learning, Capital Structure and Systemic Risk.” Standard dynamic structural models of financing assume firms know the stochastic process governing cash flow. I will first consider a partial equilibrium model. Here firms are exposed to rare event risk, with the true probability being unknown. Firms learn and update beliefs regarding risk. Relative to standard models, firms are debt conservative and there is leverage persistence. In many cases, firms increase leverage only if they have avoided a negative shock long enough. In order to analyze asset pricing implications, I plan to embed such firms in a general equilibrium setting with a common catastrophic risk having unknown probability. Firms rationally respond to “Great Moderations” by increasing leverage. Recessions are more severe after long tranquil periods due to high debt overhang. A third paper, Re-Examining the Link Between Leverage and Systematic Risk, considers cross sectional asset pricing implications of credit shocks. The standard levered beta formula is erroneous, and the pre-tax cost of capital increases with debt. Together, the models show privately optimal debt is lower than recognized, and that tax breaks for debt reduce welfare.Empirical Testing: “Natural Experiment Policy Evaluation—A Structural Critique.” A common approach to testing whether taxes influence corporate financing and investment decisions is to compare leverage and investment before/after tax changes. I use a structural model as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combinatorial structure of intractable problems' (COMBSTRU) under Fifth Framework.

assistant: **Objectives**

The whole project arises from the need to integrate different approaches to study discrete mathematics and the need to expose young European researchers that aim to work in discrete mathematics and theoretical computer science to a large array of techniques. We feel that at present no European university is providing such training. Moreover, this can only be achieved through an interdisciplinary project like the present one, where young researchers and students spend some time working with different teams and through a planned series of schools and itinerant guest lecturers, that will go through the different sites recurring about their field of expertise. At the middle of the project, a special school is planned for gifted undergraduate students from any European university where they will be introduced to the techniques and problems in contemporary discrete mathematics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Recycling Electronic Waste to Catalyse H2 Production and CO2 Reduction Using Recovered Metals: A Step towards Circular Economy' (REWCHEM) under Horizon Europe.

assistant: **Objectives**

This proposal combines physical science research with metallurgical process design and engineering to promote positive change in the electronic waste (e-waste) industries and create economic and societal benefits for the world. We undertake coordination and supramolecular chemistry research to understand and develop reagents for e-waste metal separations, integrate this insight into practicable solutions for e-waste recycling, and translate research outputs into innovation for the e-waste industry in a sustainable way. We utilize the recovered precious metals from e-waste to develop catalysts for hydrogen evolution and CO2 reduction through electrochemistry. Hence, the proposal targets three key agenda of the Horizon Europe Framework Programme and the United Nations Sustainability Goals, i.e., circular economy, sustainable energy, and environment.


**Keywords:** Electronic waste, Recycling, Precious metals, Sustainable chemistry, Hydrogen generation, CO2 reduction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Molecular Nanomagnets at Surfaces: Novel Phenomena for Spin-based Technologies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Molecular nanomagnets, also known as Single Molecule Magnets (SMMs), are a class of molecules that at low temperature exhibit magnetic hysteresis of pure molecular origin and not related to a cooperative effect. In the past fifteen years they have attracted  great interest for their potentiality to act as magnetic memory units and for the many quantum effects in the dynamics of their magnetization. Recently our observation that the magnetic bistability is retained when a tetranuclear iron(III) molecular cluster is grafted to a metallic surface has renewed the interest in these materials, which appear the ideal candidates for fundamental investigations on the interplay between conducting electrons and magnetic degrees of freedom in the emerging field of molecular spintronics. In this project we plan to benefit from our leading position in the research on SMMs to explore novel phenomena originated by the combination of SMMs with conducting and magnetic substrates in hybrid structures. Our interdisciplinary approach starts  from the design and synthesis of SMMs and includes their assembling on surface from solution or in high vacuum as well as the tuning of the interaction with conducting, and magnetic substrates through chemical tuning of SMMs. We will focus on the quantum dynamics of the magnetization that seems particularly affected by the interaction with a magnetic substrate opening perspectives for novel spintronic devices and for an unexplored strategy to increase the blocking temperature of SMMs. Additional aspects will be investigated, in particular the use of switchable magnetic molecules as well as the possibility to modify the interface with yet unexplored approaches, for instance exploiting the magnetic torque on molecules with large magnetic anisotropy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FIRST-IN-CLASS MYC INHIBITOR: THE MAKING OF A BREAKTHROUGH CANCER THERAPY', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, with very few and often ineffective therapeutic options. Despite recent advances, cancer therapies remain ineffective and/or highly toxic. Our approach is targeting MYC, a function essential to cancer cells that allows them to survive and develop resistance to therapy. In contrast to standard drugs, inhibiting MYC selectively blocks tumor progression without causing important side effects. MYC has been considered undruggable for a long time, and no clinical MYC inhibitor is yet marketed. Peptomycs first-in-class drug, OMO-103, is a cell-penetrating mini-protein that derives from Omomyc, the best MYC inhibitor known to date. OMO-103 recently completed a Phase 1 clinical trial that confirmed its safety and clinical activity in all-comers solid tumor patients, causing a 49% tumor shrinkage in a PDAC patient and stabilizing the disease of 8 out of 12 evaluable patients. Moreover, using AI we identified a predictive and a pharmacodynamic circulating biomarker signatures, and generated companion diagnostic for stratification and real-time response monitoring tests for OMO-103. OMO-103 and its companion diagnostic tests offer a promising therapeutic option for a disease in great need and could apply to treat many other cancer indications. The next steps and goals of this MYCureX project consist of conducting a Phase 1b trial in 1st-line PDAC patients, combining OMO-103 with the standard of care, to evaluate its safety and clinical activity; refining the companion diagnostic prototypes and app; securing the scale-up of the innovation by developing a commercial-scale compatible manufacturing process; and expand the applications of OMO-103 and Peptomyc's drug pipeline. By completing MYCureX, Peptomyc will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular study of Indian peanut clump virus transmission by polymyxa graminis led' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content Indian peanut clump virus (IPCV) infects groundnut plants (Arachis hypogea L.), causing serious losses to peanut crops in the Indian sub-continent. IPCV is related to peanut clump virus which causes similar disease in African crops, both are i transmitted by Polymyxa sp.. The mechanism by which the virus is acquired by the fungus and is transmitted to host plants is unknown. Recently, a laboratory based system for studying IPCV transmission by Polymyxa zoospores was established at UCL, Louvain. Understanding the virus component of the transmission would be much enhanced by being able to make known mutations in the virus genome. The objective of the research is to obtain cloned cDNA in such a form that infective IPCV can be recovered from it. The work will involve (1) purification of virus RNA from an isolate recently transmitted by fungi, (2) PCR amplification and construction of a full-length cDNA clone for each genomic RNA, (3) preparation of mutants in open reading frames (ORF) possibly involved in transmission, (4) expression of mutant clones in plants by inoculation of transcript RNA or agro-inoculation of cDNA in a Ti plasmid. Virus clones will be sent to UCL for analysis in the Polymyxa transmission system Training content (objective, benefit and expected impact) Develop the expertise of the applicant in molecular virological techniques (molecular plant virologist are few in Europe), including c-DNA cloning, sequencing, mutagenesis and agro-inoculation. The work will be performed with already existing research programs at SCRI, UCL, and ICRISAT (International Crops Research Institute for the Semi-Arid Tropics), and will take the opportunity of recent research achievements for a better understanding of virus transmission by fungus,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Challenging the gaps in global cancer concepts by a real life tumor: human childhood neuroblastoma' to be submitted under Seventh Framework.

assistant: **Abstract**

The successes of cancer research stem from the identification of oncogenes and tumour suppressor genes and the study of their pathways in animal and cell line models. Confronting these models with ‘real life’ human cancer has often been a challenge. This grant aims at integral understanding of the aggressive childhood tumor neuroblastoma. Starting point is a huge database for this tumor. We established mRNA, miRNA, CGH and SNP profiles for a series of neuroblastoma, and sequenced their whole genomes. Over 1500 mRNA profiles of cell lines with manipulated gene expression complete this resource. A novel bioinformatic platform integrated all molecular and clinical data. Several research topics have emerged: (1) Recurrent mutations were detected in neuronal growth cone genes. We will investigate whether failed neuritogenesis is oncogenic; (2) Contrary to the paradigm that cancer is caused by gene mutations, our data suggest that human tumours equally much result from chromosomal gains and losses. They proportionally change the expression of hundreds of otherwise intact genes. We will investigate how copy number changes activate oncogenic pathways. (3) Each neuroblastoma includes two cell types, which at low frequency convert into each other. They differ in mesenchymal and neuro-epithelial character, cancer pathway activation, motility and drug sensitivity and thereby are at the crossroads of cancer stem cell-, drug resistance- and metastasis-research. Transgene expression could induce transitions between both cell types in vitro, which will allow us to elucidate the wiring of both states. (4) Neuroblastoma can go in remission upon treatment, but often relapse as fatal therapy resistant tumour. This plasticity may stem from resistant mesenchymal cells, inter-conversion of ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'EFFECT OF COPPER IN THE FOOD CHAIN ON HUMAN HEALTH'.

assistant: **Innovation**

Oxidant damage has been implicated in the pathology of a number of human diseases including cardiovascular disease and cancer and important biological defence systems have evolved to limit such damage. These antioxidant defences are inter alia dependent on dietary antioxidants. There is now substantial evidence that an optimum level of Cu is required to maintain antioxidant defence systems within the body and that Cu deficiency in animals increase oxidant stress. Although severe or clinically-defined Cu deficiency in humans is not a public health problem, there is concern by some that a disparity may exist between putative Cu requirements and mean apparent intakes in Western populations resulting in widespread mild, sub-clinical Cu deficiencies. Dietary Cu requirements are uncertain but must published recommended dietary intakes vary around 1-2mg/d. The majority of dietary intakes in Western populations are around or below these values.The information provided by the research should give a better understanding of the precise requirements for dietary Cu and elucidate the balanced interactions which occur within the whole diet with respect to Cu.The technical and scientific objectives of this research are :- to provide data on the significance of increased dietary Cu (provided by Cu supplements) as a pro-oxidant or antioxidant in vivo in both free-living men and women;- to provide data on how formulated low, medium and high Cu diets fed to male and female volunteers in metabolic units can affect risk factors for cardiovascular disease, fructose/copper interactions and biomarkers of bone turnover;- to provide data on Cu bioavailability in humans using an oral challenge of 65Cu stable isotope;- to provide in vitro data on the molecular mechanisms of Cu absorption and metabo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Functional Architecture of the Brain for Vision' (FAB4V).

assistant: **Concept**

We are visual animals. Seeing is our prime means for probing the outside world. Although vision appears effortless, we dedicate about a quarter of our most precious organ to this most prominent of all senses. The primary objective of this research programme is to develop a rigorous new view on how the human brain process visual information. This endeavour is based on two concepts: the methodological issue of necessity and the theoretical framework of cortical networks.In the last decades, electrophysiological and neuroimaging studies have identified more than 40 separate maps in the brain that are selectively tuned to specific visual features, such colour or motion. Brain-behaviour relationships inferred from electrophysiology and functional neuroimaging are per definition correlational. We need neuropsychological research with patients who suffered focal brain damage to show us which brain structures are necessary. Only structures that, when damaged, have a selective detrimental effect on the execution of that function are necessary. Other structures that are activated during the execution of that function are merely involved in associated processes.Having established which brain structures are necessary for a specific function, the proposed research programme will investigate how these necessary maps are linked together. As a theoretical perspective, this programme adopts a critical position towards the “what and where pathways” model of Goodale & Milner, the current gold standard. The model postulates two major pathways, each involving a large number of maps; one for processing visuospatial information for motor programming, and one for visual recognition and memory. I have recently suggested an alternative model in which the maps are thought to be organised in multi