RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing the EU Biodiversity Research Strategy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Main:The main objective of BIOSTRAT is to support the further development of a European Biodiversity Research Strategy. Such Research Strategy brings together ideas on research priorities in fundamental and applied sciences to address critical gaps in know ledge on the conservation and sustainable use of biodiversity. This Strategy is intended to support the decision-making process regarding biodiversity-related research at both the European scale and in individual EU Member States by linking existing structures. Rather than developing new structures BIOSTRAT will provide specific support to EPBRS (European Platform for Biodiversity Research Strategy), which provides a representative forum for researchers, science and environmental policy makers, and National Biodiversity Platforms.At the same time BIOSTRAT will ensure that other European and international efforts to develop research strategies in different fields of biodiversity research are linked to the development of a European Research Strategy through t he EPBRS forum. BIOSTRAT will, therefore, support other international initiatives to link their efforts to the European Biodiversity Research Strategy.The overall objective will be achieved by:- Supporting the European Platform for Biodiversity Research Strategy (EPBRS) to develop and continually revise the EU Biodiversity Research Strategy- Including the results of existing and ongoing biodiversity research projects in the development of the EU Biodiversity Research Strategy.- Linking the EU Biodiversity Research Strategy to the national, European and international funding programmes, especially the ERA-Nets related to biodiversity issues- Incorporating GEOSS objectives in the EU Biodiversity Research Strategy- Linking EU Biodiversity Research Strategy with intern
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The influence of multiple global change stressors on marine communities: a novel field approach'.

assistant: **Objectives**

Marine habitats are socially and economically important to millions of people around the world, but accelerated global climate change poses a significant threat to aquatic organisms and communities. Accurate predictions of the effects seawater warming and other stressors on marine resources are needed to successfully manage our seas and plan for future change. Of all the facets of global change, increasing temperature is perhaps the most important, as temperature affects all biological processes. In terrestrial systems, researchers have used polytunnels and cloches to manipulate climate to investigate the effects of warming on community structure, dynamics, and biodiversity. There have been no such experiments conducted in the marine realm. As such, a major knowledge gap relates to the lack of field-based experiments conducted on marine organisms to date, and most knowledge stems from highly artificial laboratory manipulations. This project will employ a novel technique to manipulate temperature in situ, to examine the effects of warming on marine communities on hard surfaces. The ‘hot-plate’ technology has been developed in Australia over the last 2 years, and has facilitated the first controlled manipulation of temperature in a marine habitat. This project will support transfer of knowledge, facilitate further development of this technology, and allow comparative experiments to be conducted in both Australia and Europe, thus enhancing the ecological relevance of the work. Warming experiments will be combined with simultaneous manipulations of other global change stressors (sedimentation, nutrients, physical disturbance, seawater chemistry) to investigate the effects of multiple factors on the recruitment, growth and development of marine communities. The research has
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Finite element simulations of mechanobiology in tissue engineering' under Seventh Framework.

assistant: **Concept**

The influence of mechanical stimuli on cell behaviour also known as mechanobiology has led to the development of mechano-regulation theories and finite element simulations that predict tissue formation in regenerative medicine. Computer simulations can explore mechanotransduction processes on the cellular level which are not possible to measure experimentally. However, most studies are limited to continuum macroscopic description of the tissues and therefore are inadequate to relate macroscopic loading to microscopic mechanical stimuli. The main objective of this project is to reach new frontiers in mechanobiology with the development of a new approach in the modelling of tissue engineering with an integration of the microscopic modelling of cells with the macroscopic modelling of the scaffold. A discrete approach to model the porous scaffold will be combined with a multitude analyses of single cell biomechanics attached onto the scaffold. In order to validate the overall methodology, each of the different modelling steps will be modelled through the development of in vitro experiments on adult human mesenchymal stem cells. The breakthrough of this project will change considerably the methodology used previously by the scientific community in this field and in the development of the biomedical field regarding computer modelling. The impact of this project will bring a better understanding of the local mechanical stimuli on cells and the understanding of the translation of mechanical macroscopic loading onto microscopic loading.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Harnessing tumor metabolism to overcome immunosupression' (ImmunoFit) under Horizon 2020.

assistant: **Objectives**

Anti-cancer immunotherapy has provided patients with a promising treatment. Yet, it has also unveiled that the immunosuppressive tumor microenvironment (TME) hampers the efficiency of this therapeutic option and limits its success. The concept that metabolism is able to shape the immune response has gained general acceptance. Nonetheless, little is known on how the metabolic crosstalk between different tumor compartments contributes to the harsh TME and ultimately impairs T cell fitness within the tumor. This proposal aims to decipher which metabolic changes in the TME impede proper anti-tumor immunity. Starting from the meta-analysis of public human datasets, corroborated by metabolomics and transcriptomics data from several mouse tumors, we ranked clinically relevant and altered metabolic pathways that correlate with resistance to immunotherapy. Using a CRISPR/Cas9 platform for their functional in vivo selection, we want to identify cancer cell intrinsic metabolic mediators and, indirectly, distinguish those belonging specifically to the stroma. By means of genetic tools and small molecules, we will modify promising metabolic pathways in cancer cells and stromal cells (particularly in tumor-associated macrophages) to harness tumor immunosuppression. In a mirroring approach, we will apply a similar screening tool on cytotoxic T cells to identify metabolic targets that enhance their fitness under adverse growth conditions. This will allow us to manipulate T cells ex vivo and to therapeutically intervene via adoptive T cell transfer. By analyzing the metabolic network and crosstalk within the tumor, this project will shed light on how metabolism contributes to the immunosuppressive TME and T cell maladaptation. The overall goal is to identify druggable metabolic targets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cloud-based Monitoring Service for Software Defined Networks' (SDN-Polygraph), addressing dissemination and exploitation.

assistant: **Impact**

Most enterprises depend on the Internet and on computer networks. Costs associated to network malfunctions are huge and have been estimated via market surveys from around 30,000€/hour on average, which yields average yearly losses of more than 5M€ per company. Because network downtime is so costly, companies invest in network visibility solutions. The market of Network Performance Monitoring (NPM) is currently estimated at 2,200M€, growing at >11% yearly.However, enterprises are still not investing as much as they should in network visibility, for two main reasons: Deployment complexity and Upfront costs. Current products are hardware based, are very expensive and their license costs must be paid up-front. Should these two barriers fall, the NPM market would explode, as every mid-to-large company, even the larger SMEs, would acquire such solutions.The first requirement to avoid malfunctions and correctly operate a network is visibility (the ability to understand what happens in a network). A technical revolution is currently undergoing, called Software-Defined Networking (SDN). SDN allows software components to act on the network and make it “programmable”.SDN opens the door to create a zero-hardware network visibility product that can be deployed with one click, seamlessly collect network traffic statistics, and send them to the cloud for analysis and can also alter the behaviour of the network based on that analysis. Through SME Instrument Phase 1, Talaia has developed a Minimum Viable Product demonstrating its technological viability, has implemented a Business Plan which proves the feasibility of the solution and has placed itself in an advantageous position to gain this new market niche.Talaia will develop a fully-featured product, and offer it as a service using t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Semiclassical Spin Dynamics in Condensed Phase' under Horizon Europe.

assistant: **Concept**

Quantum mechanical, spin dynamic calculations for NMR purposes, rapidly becomes very complicated when the studied spin systems increase in size. In this project we aim to study methods in which semiclassical molecular dynamics are explored to tackle this problem. Methods for semiclassical approximations have since long times been established within the fields of radical chemistry and optical spectroscopy research but are little explored within the field of NMR. We intend to explore methods where in addition to a smaller completely quantum mechanically described spin systems are investigated, the complete (large) nuclear surrounding is included in a classical manner. More specifically we will add Hamiltonian terms of the Caldeira-Leggett type and eventually simulate the anharmonic environment with ab initio molecular dynamics or empirical force fields. The benefit of the proposed strategy is that matrix size increases linearly with the number of nuclei included instead of exponentially if the environment can be described classically. This will be done by a step by step project plan in which during the earlier work packages investigations of spin systems without the environment included is done. Then once, we have established suitable quantum dynamics methods, we will proceed to include the environment. If this succeeds and we manage to correctly calculate spin dynamics with the impact of the environment in terms of relaxation taken into account, we will continue to the later work packages and try to use this to aid NMR pulse design. If this is successful, this project will open doors to more efficient NMR simulations and provide quantum physical insights to NMR dynamics.


**Keywords:** Semiclassical Molecular Dynamics, Quantum Dynamics, solid state NMR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A NOVEL NON-INVASIVE DNA METHYLATION TEST FOR MELANOMA' (MitraTest).

assistant: **Concept**

Early cancer detection is a key to improve survival rates. For melanoma the survival falls from >98% at Stage 1 to 22% at Stage 4.Currently, skin biopsy is the only method of melanoma detection. It is an expensive and invasive procedure. Our patented technology, is a combination of a unique non-invasive tape strip skin sample collection technique and proprietary DNA methylation panel specific for melanoma. This will allow quick and inexpensive testing for melanoma at GP level and as an at-home test kit.Our proof of concept study with Guy’s Hospital (UK) showed over 95% specificity and 85% sensitivity in detecting melanoma compared to standard biopsy procedures.Mitra Bio is a female-led team of 6 scientists and business developers with experience in building diagnostics platforms. We aim to improve melanoma detection and reduce melanoma health and economic burden, which currently results in 15K deaths/year in the EU.


**Keywords:** cancer, melanoma, skin disease, DNA methylation, biopsy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neurocomputational mechanisms underlying adaptive flexibility  in cognition, emotion and behavior' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ability to adapt behavior to unfamiliar situations is crucial in our complex and ever-changing world. In such circumstances, we often rely on the statistical structure of our environment, allowing us to generalize previously learned behaviors to new, similar situations. Two brain regions are key to this flexibility: the hippocampus, which creates cognitive maps that represent the structure of the world, and the prefrontal cortex, which accesses and uses these representations based on current task demands. In addition to their cognitive functions, both regions are also involved in regulating emotional aspects of our experiences. However, even though it is often the interplay between cognition and emotion that plays a central role in well-being and psychopathology, cognition and emotion are often studied in isolation. CogFlex challenges this compartmentalized view and proposes a unified framework, suggesting that emotions directly shape how we represent the world and thereby influence how we generalize, update, and act on information.Using a combination of sophisticated human neuroscience methods, including high-resolution functional magnetic resonance imaging (fMRI), intracranial recordings, and advanced computational models, CogFlex will offer unprecedented details in how the human brain forms, uses, updates and selects cognitive maps and how emotions interact with these processes. Notably, CogFlex will move beyond observing correlations by non-invasively manipulating hippocampal and prefrontal representations using transcranial temporal interference stimulation (tTIS), offering causal insight into the role these brain regions play in selecting and using cognitive maps for guiding flexible behavior.Through this integrative approach, CogFlex will provide a deep mecha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Development of alternative control methods for the chicken mite - dermanyssus gallinae'.

assistant: **Innovation**

The overall objective of the proposal is the development of new control methods for the chicken mite, Derma- nyssus gallinae, a major arthropod pest affecting the health and welfare of poultry, and also a threat to human health due to its capacity to carry bacteria such as Salmonella. The new control methods will be based on the employment of a combination of naturally occurring semiochemicals (attractants) influencing mite behaviour and mite pathogenic fungi (biological control agents) in a lure-and-kill strategy. Such control methods will have a positive impact on the transition to sustainable egg production, and will allow a reduction in the use of persistent broad-spectrum synthetic insecticides. The overall objective will be achieved as the result of three workpackages:1) isolation and identification of semiochemicals attractive to D. gallinae,2) isolation and selection of mite pathogenic fungi with high virulence against chicken mites and with good field persistence, and3) development of a prototype trap based on a combination of the identified semiochemicals and the selected fungal isolates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exudation Agriculture: Highly Efficient and Continued Production of Carminic Acid Pigment for the Natural Colorants Industry' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Natural pigments are gaining importance in the EU as safer and more sustainable alternatives to synthetic colorants, but their use also presents challenges which have been hindering their wide adoption in the colorants market, particularly in terms of scalability, cost, and ethical sourcing. Carminic acid is widely used as a natural alternative and exemplifies these production challenges: it requires a labour-intensive extraction process, has negative ethical and environmental impacts for insect cultivation and exploitation, and its production is unpredictable due to external factors like weather fluctuations. Our PoC project introduces a groundbreaking technology for the sustainable production of target metabolites like Carminic acid. We aim to demonstrate the feasibility of using our innovative technology to produce cheaper and more sustainable natural colorants and to develop a comprehensive Business Plan to ensure the technology's market readiness and sustainability. Furthermore, we will conduct thorough market analysis and industry discussions to test our business case with relevant stakeholders, while also identifying potential funding sources to support future commercialization efforts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Global challenges and bio-based economy: Assessing institutional structures, constraints and outcomes of bio-based research in Agriculture (ISCOBRA)' in the context of a Seventh Framework call.

assistant: **Objectives**

The rise of the bio-based economy is expected to deliver significant benefits to society in terms of health, agriculture and environment in particular. These advances in the life sciences are increasingly relying on open cooperation and collaboration nationally, regionally and internationally.  It is one of the driving forces behind the push for broader access and open systems approach for the flow of information, materials and ideas. At the same time, in the area of genetic resources — one of the major material inputs for bio-based innovations— new regulatory requirements are profoundly impacting the way life science is conducted, in particular the balance between openness and proprietary rules in research. These new global regulatory requirements are affecting the capacity of scientist to acquire new material for their research.The rise of the bio-based economy and the increase in institutional constraints over biological materials are occurring at the same time. Within this context, science policy research can no longer possible to assume that collaborators have control over the inputs to research. This project aims to analyze how global policy changes that regulate access to material inputs to research impact the evolution of norms that guide scientific research in the new bio-based economy in the agricultural sector. Specific attention is paid to changes in international scientific collaboration and impact on research outputs and outcomes.  The project has identified two primary objectives. The first one aims to assess the impact of global policy changes that affect access to material inputs to research on norms, values and practices of international scientific collaboration in bio-based research for agriculture. The second one aims to better understanding the adva