RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Soft and biological quantum light sources' (SoftQuanta).

assistant: **Concept**

Quantum optics is an exciting and rapidly growing research field with a huge potential in different applications such as quantum communications, computing, sensing, and imaging. One of the most crucial components of any quantum optical device is a source of non-classical light, called a quantum light source. Currently, these sources are almost exclusively based on solid-state inorganic materials, which limits their properties, such as lack of complex geometries and limited tunability.In the past, I have pioneered the use of liquid crystals and biomaterials to make various photonic devices. Notably, I made a laser inside a live human cell. Since then, this pioneering work has been employed in a large number of applications, including tunable light sources, biological sensing, cell barcoding, and imaging. Soft photonic devices have unparalleled properties compared to their solid-state counterparts, such as extremely large tunability, self-assembly of complex structures that are impossible to make by lithography, biocompatibility and even self-healing.Similarly as with microlasers, I propose to make quantum light sources from soft and biological matter. The unique properties of soft materials have the potential to give an unprecedented twist to the field of quantum optics but have been unexplored until now. I propose to develop sources of photon pairs out of liquid crystals. By selecting the appropriate liquid crystal structure, these sources will generate almost arbitrary polarization quantum states of the photon pairs, including entangled photons. Moreover, the quantum states will also be tunable by an electric field. Further, I propose to use single-photon sources in biological materials for novel applications such as cell barcoding and to make a purely biological singl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Plasmons Generating Nanocomposite Materials (PGNM) for 3rd Generation Thin Film Solar Cells' (PGNM).

assistant: **Concept**

The objective of the SOLAMON project is to develop high potential Plasmon Generating Nanocomposite Materials (PGNM) which will pave the way to the generation III solar cells (high efficiency & low cost).  The objective is an augmentation in the External Quantum Efficiency resulting in an increase of 20% in the short circuit current density of the thin film solar cells. To achieve such an ambitious goal, the project will focus on the development of fully tailored building block nanoparticles able to generate a plasmon effect for enhanced solar absorption in thin film solar cells. Such nanoparticles designed for an optimum absorption will be integrated in solar cells matrix using a recently developed room temperature deposition process. This step will result in the specific design of PGNM for solar cells using a knowledge based approach coupling modeling at both scales: nanoscopic (plasmonic structure) and macroscopic (solar cells). SOLAMON will address three different classes of solar cells: a-Si:H thin films, organics and dye sensitised. Developing the PGNM on these three classes aims at maximizing the project impact and not to compare them because scientific background acquired on these technologies could be easily transferred to other ones. As a matter of fact, a-Si:H technology targets mainly the BuiIding Integrated PV (BIPV) market (large surfaces) whereas the two others are most suitable for the consumer good market (nomad applications). The project workprogram, the critical path and the contingencies plans are designed to maximize both social and economic impact. For this reason, the BIPV applications (i.e. a-Si:H based technology) will be firstly considered when a strategic choice occurs, keeping in mind that, even of large economic importance, the two other tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identifying molecular features of potent antibody and memory B-cell responses associated with RTS,S malaria vaccine efficacy' in the context of a Horizon Europe call.

assistant: **Objectives**

Malaria is the most important parasitic disease being a leading cause of death among young children, particularly in sub-Saharan Africa. In the context of the World Health Organization (WHO) strategic goals for a world free of malaria, there is a strong need of highly efficacious vaccines. Despite the RTS,S/AS01 (RTS) vaccine candidate was recently approved for use in African children, it demonstrated a modest efficacy during phase 3 clinical trials. Hence, a better understanding of the determinants of long-lasting immunity induced by the RTS,S is required to support improved next-generation vaccines aiming to provide the maximum coverage to target populations. In this regard, previous serological analyses demonstrated that high antibody levels and avidity are associated with vaccine efficacy in African children recipients. However, the molecular mechanisms and the cellular immune phenotypes supporting such potent antibody responses have not been fully deciphered. To fill these knowledge gaps, we propose to develop an in-depth humoral immunoprofiling within the large multicenter RTS,S phase 3 clinical trial, using already collected samples from African children participants. By generating a collection of antigen-specific monoclonal antibodies, I will investigate the molecular features of the RTS,S-induced memory B-cell response and the most relevant target epitopes. In parallel, I will identify the lymphocyte populations mobilized upon highly responding serological profiles, to subsequently develop a multivariable analysis integrating clinical-epidemiological, serological and cellular datasets to elucidate hallmarks of potent antibody responses and vaccine efficacy.


**Keywords:** Humoral immunology,  memory B cells,  monoclonal antibodies,  systems immunology,  malari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unravelling the genetic codes governing transposon mobilization'.

assistant: **Concept**

Transposons are ubiquitous DNAs capable of changing their genomic locations. While historically perceived as detrimental and damaging to host genomes, they have also been a major source of genetic variability, driving evolution. Unfortunately, the regulatory mechanisms of transposons remain largely unknown, primarily due to the lack of experimental methods to trace their movement. This project therefore aims to dissect the regulation of transposons in plants with unprecedented detail. This goal is enabled by a distinctive method developed in my lab, RUM (Real-time detection of transposon jUMping). RUM provides real-time, single-cell detection of transposon movement, offering a powerful platform to unravel the complexities of transposition regulation. Specifically, this project will focus on three major objectives investigating at multiple scales, from tissue to cellular and molecular levels. Firstly, it has long been assumed that transposition occurs more frequently in somatic tissues, however, this assumption has yet to be empirically validated. To comprehensively evaluate cell type-specific transposition activity, I will integrate RUM with single-cell RNA sequencing. This approach will provide a detailed map of cellular competence for transposition. Secondly, while epigenetic silencing is well known as a mechanism controlling transposons, significant gaps remain in our understanding of post-transcriptional and pre-integrational regulation. To identify novel regulators of transposition, I will perform a custom genome-wide CRISPR screen in combination with RUM. Thirdly, internal and auto-regulatory sequence motifs within transposons remain poorly studied. To address this, I will generate random mutations within RUM and map mutation hotspots associated with active transp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Preventing and responding to conflict: developing EU CIVilian CAPabilities for a sustainable peace' (EU-CIVCAP).

assistant: **Innovation**

The goals of preventing the outbreak of conflict and promoting sustainable peace remain a fundamental challenge to policymakers and analysts alike. The European Union (EU) and its member states require an adequate set of capabilities if they are to address this challenge in a timely and effective manner. EU-CIVCAP will provide a comprehensive, comparative and multidisciplinary analysis of EU civilian capabilities for external conflict prevention and peacebuilding in order to identify ‘the best civilian means to enhance these capabilities’ and address existing shortfalls. More specifically, this project has identified three inter-related objectives: (1) To assess EU civilian capabilities for external conflict prevention and peace building; (2) To identify and document lessons learned and best practices in EU conflict prevention and peacebuilding; (3) To enhance future policy practice and research on EU conflict prevention and peacebuilding. The project will gather, synthesise, further develop and disseminate knowledge and learning on civilian conflict prevention and peacebuilding. This will be done through, inter alia, the development of a catalogue of lessons learned and best practices reports, the creation of an expert network, engagement through social media, and the organisation of dissemination events in different formats in this area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EXtreme-scale Analytics via Multimodal Ontology Discovery & Enhancement' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Exascale volumes of diverse data from distributed sources are continuously produced. Healthcare data stand out in the size produced (production 2020 >2000 exabytes), heterogeneity (many media, acquisition methods), included knowledge (e.g. diagnostic reports) and commercial value. The supervised nature of deep learning models requires large labeled, annotated data, which precludes models to extract knowledge and value. EXA MODE solves this by allowing easy & fast, weakly supervised knowledge discovery of exascale heterogeneous data provided by the partners, limiting human interaction. Its objectives include the development and release of extreme analytic methods and tools, that are adopted in decision making by industry and hospitals. Deep learning naturally allows to build semantic representations of entities and relations in multimodal data. Knowledge discovery is performed via document-level semantic networks in text and the extraction of homogeneous features in heterogeneous images. The results are fused, aligned to medical ontologies, visualized and refined. Knowledge is then applied using a semantic middleware to compress, segment and classify images and it is exploited in decision support and semantic knowledge management prototypes. EXA MODE is relevant to ICT12 in several aspects: 1) Challenge: it extracts knowledge and value from heterogeneous quickly increasing data volumes. 2) Scope: the consortium develops and releases new methods and concepts for extreme scale analytics to accelerate deep analysis also via data compression, for precise predictions, support decision making and visualize multi-modal knowledge. 3) Impact: the multi-modal/media semantic middleware makes heterogeneous data management & analysis easier & faster, it improves architectures for com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Study of HIV-1 variability in Cameroon and Gabon implications for vaccine and antiviral intervention strategies' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

* To provide a surveillance system for newly emerging and naturally occurring recombinant HIV-1 strains in Cameroon and Gabon.* To classify sera from HIV infected individuals according to their capacity to neutralise primary isolates representing different genetic clades.* To characterize broadly neutralising antibodies and epitopes in individuals infected with HIV-1 of different genetic subtypes, and evaluate the role they play in disease protection.* To investigate the susceptibility of HIV-1 strains belonging to different genetic clades, to both existing and experimental anti-HIV compounds and to provide a surveillance system for emerging strains of HIV-1 with naturally occurring mutations conferring antiviral drug resistance.* To optimize the quantification of HIV RNA in plasma of patients infected with different types, subtypes and recombinant subtypes of HIV.Expected OutcomeMaking available to developing countries a simple economical serologic test to monitor circulating HIV-1 subtypes.The study design will be as follows: both heteroduplex mobility assay (HMA) on PCR amplified fragments generated from HIV RNA in serum or plasma of HIV infected individuals and V3-peptide ELISA will be used to monitor the prevalence of different genetic subtypes of HIV-1. HMA on both gag and env fragments of the same isolate will allow to study the prevalence of recombinant viruses. Susceptibility of the different subtypes and the natural recombinant viruses towards various HIV inhibitors will be determined. Neutralizing antibody patterns in sera of individuals infected with all subtypes (A-H) within group M and representatives of group O to their homologous and heterologous primary isolates will be documented using a peripheral blood mononuclear cell based neutralisation assay. Neu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Water Efficiency in European Urban Areas' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

WE@EU is a coordination action born from the initiative of a wide range of actors from five different European regions that have a true awareness on problems related to availability of water in sufficient quantities and adequate quality in their regions. Taking into account that over 80% of the population is expected to be living in urban areas in EU countries by 2050, pressures on the availability of water, also under the effects of the climate change phenomenon, is becoming a major challenge at European and global level. WE@EU has been conceived to coordinate european innovation in the water efficiency market of products and services through high-levelcooperation between five European regions represented by research-driven clusters. The five participating regions are envisaged to identify common solutions towards the development of effective R&D&I policies trough knowledge transfer, mutual learning and capacity building,in a coordinate collaboration with R&D&I performers, the business sector, regional authorities/policy makers and civil society. WE@EU will promote the delivery of innovative solutions, skills and policyinstruments to support to boost competitiveness of the participating regions towards a moreresource-efficient economy.Ultimately, WE@EU is expected to set up the base for a higher specialization degree in water-efficiency, contributing to the development of their Regional Innovation Strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Patient education in parkinson's disease (EDUPARK)' (EDUPARK), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of this project is to improve the quality o life of people suffering from a chronic degenerative disease, i.e. Parkinson's Disease (PD) through patient education and psychosocial support. The importance of patient education and psychosocial support (in addition to medical treatment) cannot be overemphasised given the complexities of PD. Recommendations for patient education and psychosocial support will take into account the existing situation of PD patients in the 7 European countries participating in this project. Three treatment modules will be implemented which focus on the patient's problems as well as those of the carer. These modules will form part of a standardised patient education and training programme, which will be developed by national experts of the participating countries and will be implemented by interdisciplinary rehabilitation teams.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Toward the microscopic simulations of cell-like environments.' (CROWDY) targeting Horizon 2020.

assistant: **Abstract**

In living cells, proteins operate in an extremely crowded environment, which has a substantial impact on their structural and dynamical properties. Taking into account the effects of macromolecular crowding is thus imperative for a full understanding of protein function in vivo. However, despite a growing interest in the characterization of in-cell crowding, its net effect remains only partially understood as experimental studies addressing such phenomena in the cytoplasm are very challenging. In this project, we aim to examine the effect of macromolecular crowding on protein mobility and stability at the microscopic resolution. To this end, we will deploy a novel multi-scale simulation approach developed in the host laboratory. This multi-scale framework combines a detailed description of proteins with an efficient lattice-based model of solvent hydrodynamics. In the course of the project, we will consider systems of progressive complexity, ranging from crowded binary protein suspensions through a model of a bacterial cytoplasm and a lipid vesicle forming a biological nanoreactor. Our computational studies will be performed in close contact with two top-level experimental groups active in the field. We will pay particular attention to the behavior of superoxide dismutase 1, a protein involved in amyotrophic lateral sclerosis. Our multi-scale molecular simulations will shed light on how protein dynamics and stability are locally affected by the heterogeneity of the cellular environment. Moreover, we will investigate how crowding is modulated by the presence of membrane surfaces. The simulations will allow us to clarify the origins of crowding effects at an atomistic level, which will provide a vital support for the microscopic interpretation of experimental data. Thus,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SUSTAINABLE DESIGN OF MANUFACTURING SYSTEMS' (SUSTAIN-MS) under Seventh Framework.

assistant: **Objectives**

The contribution of SUSTAIN-MS to EU manufacturing added value refers to environmental sustainability issues addressed through more efficient model-based design of manufacturing systems that will yield more efficient production by reduced waste and energy use. The way to achieve this is to apply machining processes with advanced cooling-lubrication and to adapt machine tools to such a stage that the process vibrations are decreased. In support of SUSTAIN-MS design efforts the following sustainability measures will be defined: manufacturing process energy use, ancillary energy, machine tool vibrations, tool consumption and waste, cooling-lubricants, CO2 emissions, costs, health and safety. The major milestones of SUSTAIN-MS research relate to the optimised sustainable design of machining process and cooling-lubricants parameters, the solution of vibrations stability for particular machining process and the integration of machining process micro level models with the machine tool macro level models. The SUSTAIN-MS training activities that are not directly connected to scientific and technical research include the acquirement of complementary research skills, dissemination skills, project management skills and training in education. The SUSTAIN-MS objectives are in accordance with politically endorsed sustainable manufacturing directives underlined in the EU Sustainable Development Strategy and the EU Environmental Technology Action Plan.