RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dielectric pads for high field MRI'.

assistant: **Concept**

From research centers like CEA-Neurospin in France who recently acquired a 11.7T scanner to hospitals such as Saint Thomas in UK who acquired the latest commercial 7T scanner from Siemens, healthcare has taken a tremendous leap forward those last years. Indeed, ultra-high field scanners provide images with better spatial and/or temporal resolutions that are used for early diagnosis of disease and therefore enhance their treatments. However, several limitations have been reported, hindering clinical application of these devices. At such field strengths, one of the main issues is the heterogeneous excitation of the nuclear spins. Typically, it leads to shadows or contrast losses across the human brain images at 7T but also abdomen images at 3T. Those scanners still account for around 30% of the market in 2013. To tackle this issue, several solutions are under development but due to their complexity, it will require several years before their integration into clinical routines. This is even more so given the fact that most of those solutions are active: a careful monitoring of the energy absorbed by the human body which increases exponentially with the initial field is required so it remains below safety limitations. Therefore, there is right now an unfulfilled need of a simple and effective solution for all the 3T active scanners and also for the growing market of 7T scanners. It will greatly benefit clinical imaging applications but first need to be labelled as a CE medical device (MD). The current project objective is to bring to the market a side solution developed during the FET-OPEN project Mcube. First, an industrial process for the elaboration is studied and validated. Then, elaborated prototypes safety tests such as temperature monitoring, specific absorption rate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Role of Mechanical Instabilities in leaf Development' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

We propose a combined biological, geometrical and physical study of shape formation during the development of leaves. We will test our hypothesis that the formation of complex structures during leaf patterning involves theinterplay between genetic properti es of the plant and mechanical instabilities. We show, based on geometrical principles, that simple growth profiles can generate mechanical stresses within the tissue and induce mechanical instabilities, such as buckling, wrinkling and strain focusing. The se instabilities break the spatial symmetry by setting length scales and by marking sites" on the leaf, where stresses are concentrated. Stress concentration, then, could affect further patterning of the tissue through differential growth and differentiat ion, leading to the observed complex structures. According to the new view we propose, genes involved in patterning are not, necessarily, responsible for a direct "shaping" of the leaf. Instead, they may control leaf shape and veins formation by generating simple "growth laws" and by controlling the tissue sensitivity to mechanical stresses, partially through the control of biosynthesis and activity of plant hormones. The proposed principles can be extended to include a wider class of developing systems. T he proposed work is intrinsically interdisciplinary. It will combine novel ideas and experimental techniques from both biological and physical disciplines and will integrate the specialties of several laboratories, located at different EU member/associated states. We expect the research to impact the way the development of organisms, and plants in particular, is understood. The tools developed in the proposed research will potentially be applicable to other scientific and technological fields, such as the d evelo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Deciphering the mechanisms underlying mitotic nuclear envelope remodelling in the fission yeast Schizosaccharomyces japonicus'.

assistant: **Concept**

Mitosis ensures faithful inheritance of genetic material in proliferating eukaryotic cells. Cellular genome is compartmentalized inside the nucleus, which is delimited by the double-membrane nuclear envelope (NE). The NE must be restructured during mitosis to allow chromosome segregation by the mitotic spindle and formation of the daughter nuclei. Eukaryotes perform this task using diverse approaches, ranging from fully “open” to fully “closed” mitosis depending on whether and when the NE breaks down. The fission yeast Schizosaccharomyces japonicus breaks the NE in anaphase, unlike its well-known relative S. pombe that undergoes closed mitosis. S. japonicus has already become an excellent discovery model providing critical insights into the rules underlying NE expansion and rearrangements of NE-chromatin contacts. Yet, we know little about the mitotic signalling and the effector mechanisms driving NE breakdown and reformation in this organism. Importantly, S. japonicus is uniquely suited for understanding mitotic nuclear membrane remodelling, as its mitosis does not involve the elaborate NE dynamics of higher eukaryotes, including disassembly and reassembly of nuclear pore complexes. I will combine cell biology, protein biochemistry, genetics, and next-generation sequencing approaches to understand: (1) how the evolutionarily conserved inner nuclear membrane protein Lem2 controls mitotic NE remodelling; (2) what are the molecular mechanisms of mitotic NE remodelling downstream of the important mitotic kinase Aurora B; and (3) what other novel factors drive NE breakdown and reformation in mitosis. Defects in NE remodelling result in spindle malfunction, aneuploidy and chromosome rearrangements that may compromise normal development and promote tumorigenesis. My work will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Plastic upcycling for sustainable new generation batteries'.

assistant: **Concept**

The plastic waste into the environment is a global problem which is raising concern among the population. Although there are many approaches for recycling plastics, chemical recycling is now seen as one of the most promising technologies in that it allows plastic waste to become high valuable products. Bisphenol A polycarbonate (BPC) is a common thermoplastic employed in optical devices, automobile, technologies, largely because of its mechanical properties. The chemical recycling of BPC is a carbonyl reservoir for the synthesis of carbonyl compounds, with some of these reactions considered as upcycling methods because of the high value of the products.  In REPLAXTIC EF-SE, “Plastic Upcycling for sustainable new generation batteries”, polycarbonate plastic waste will be transformed into added value electrolytes to power sustainable lithium ion batteries,  The design of the materials will start from the catalytic depolymerization of BPC using sur measure diols, bearing e.g. anionic, oxygen rich or crosslinkable groups which can boost chemical and physical performances. This pathway will enable to have a first class of liquid electrolyte that can be further polymerized to create safe solid electrolytes for future lithium batteries. The fellow Dr. Daniele Mantione has a solid international experience in organic and polymer chemistry with an impressive track record of scientific publications and prizes. The project is going to combine the chemistry expertise of Dr. Daniele Mantione with the entrepreneurial spirit and depolymerization expertise of the start-up POLYKEY. The planned secondment to Australia will ally one of the best world-knowledge about electromaterials of Prof. Forsyth to push the real application of the disruptive upcycled products. The training in materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'High quality control system for non destructive analysis of glass and non opaque materials', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The aim of the project is to develop an automatic electronic system for continuous control of all parameters relating to the size, visual appearance and chemical-physical properties of glass and non-opaque materials, particularly in connection with on-line quality analysis in real time of non-opaque glass phials for pharmaceutical use. The system is completely innovative because at present the quality control of these phials is done on a sample and manually by the operator, which raises the following problems: the operation is a difficult one and it takes a long time to analyse each item; the objective difficulty of recognising certain not unimportant flaws that are not easily visible to the naked eve, combined with the repetitive nature of the work (and inevitable fall in attention levels), mean that the manual check is not up to the standards required by the market. The present level of efficiency of this quality control needs to be improved to keep up with the increasinglv stringent quality requirements of pharmaceutical companies, as the speed of operation of filling and packaging machines improves, allowing little room for size variations and demanding a virtual absence of flaws. In existing production and testing lines it is not possible to test 100% of the products and even if it were possible the cost of such a manual control procedure would be too great for any company. The advantages of implementing an automatic system would be the following: - control of 100% of the items produced and consequent improvement in efficiency - possibility of reducing the number of rejects because the automatic system could interact in real time with the production process control logic to correct flaws as soon as they are detected.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synaptic dysfunction in Neurodegenerative Diseases' (SYNDEGEN).

assistant: **Concept**

Neurodegenerative diseases (NDDs) of aging are a growing burden on societies. Although studies on the degeneration of neurons have been a main focus of research, increasing evidence points to synapses as the site where Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) begin. There is growing evidence that synapses are sites of early and aberrant protein misfolding, aggregation and spread in NDDs. A key problem in research on NDDs has been that the normal physiological roles at synapses of the aggregation-prone proteins (β- amyloid/amyloid precursor protein, tau, α-synuclein and huntingtin), which are linked pathologically and genetically to these diseases, are not known. Using cutting-edge technologies and multidisciplinary approaches the SYNDEGEN consortium aims to bring together leading experts in cell biology, synapse biology and imaging, stem cell biology and NDDs in Europe to determine the molecular and cellular mechanisms whereby synapses become dysfunctional in AD, PD and HD for the purpose of developing novel therapies. The goal of the consortium is to train talented young scientists in interdisciplinary, innovative and collaborative research aimed at the development of novel molecular based treatment strategies for these major diseases of aging. A gap in the training of students in these important diseases is that disease expertise and novel methods to study synapses are localized in isolated groups in different locations in the EU. Similar questions are being asked about the mechanisms of synaptic dysfunction in AD, PD and HD, but no one university or company has sufficiently broad knowledge and technical expertise required to study and develop therapies for synaptic dysfunction in these disorders. This training programme will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Theoretical and experimental studies of biologically relevant processes: particle separation, polymer and membranes dynamics, molecular adhesion'.

assistant: **Objectives**

My research project can be grouped around three interdisciplinary topics (one experimental and two theoretical) of biological physics. I will work on these project in parallel with the help of one or two students. (1) Particle separation: Based on a two-di mensional array of symmetric micron sized obstacles I am planning to bluid a separating device, wich could sort brownian particles, DNA in particular, according to their diffusion coefficient. (2) Polymer and membranes dynamics: With an appropritate and si multaneous renormalization of the bond length and bending rigidity of computer models of polymeric filaments, I am developing a new method, wich could speed up the computer simulations significantly. I will also investigate (both theoretically and numerica lly) how the coupling between the concentration of membrane proteins and the geometry of lipid membranes affects the shape of membrane structures and the distribution of proteins. (3) Molecular adhesion: I will study theoretically the unbinding process of adhesion complexes (e.g. ligand-receptor pairs) in situations when the unbinding trajectory contains multiple energy barriers. I will also try to interpret some recent observations on the exchange between absorbed and desorbed proteins by making theoretica l models pf protein adsorption on solid surfaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Flexible workshop for airframe assembly' in the context of a Fourth Framework call.

assistant: **Objectives**

BE95-1018 Flexible Workshop for Airframe Assembly Within a very competitive aircraft market the successful companies will be those which will succeed in drastically reducing their costs and their cycles. A large part of the cost of an aircraft is generated by assembling the airframe. This project proposes to improve the competitiveness of European aircraft manufacturers by developing a flexible airframe assembly cell. Including a better flexibility and using improved fasteners, equipments, effectors... Such a cell will be the tool to answer tomorrow's challenge in aircraft industry. Today, assembly jigs and tools are specific to each type of aircraft and are defined according to a given production rate as soon as the program is launched. For each new aircraft or new model of aircraft or production rate modifications, the design of new tools and the disposal of obsolete assembly jigs and tools is necessary. These constraints should be reduced by: . jigs and industrial equipment flexibility (adjustable multi program tools ) . tool modularity using-standardized parts at a European level . operation mechanization for;:  - the handling of parts to be assembled.  the assembly of parts . the compactness and standardisation of effectors. This objective will be achieved by the delivery of specifications for machines, effectors and handling means. To achieve this, it is necessary to integrate the results of the research on airframe design including in association way automation and flexibility constraints. This objective will be achieved by the delivery of a specification handbook for design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Global Assessment of the Limits of Groundwater Use' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Population growth and economic development have dramatically increased the demand for food and water. The resulting expansion of agriculture into areas with limited precipitation and surface water has greatly increased the reliance on groundwater irrigation. Further, urban groundwater use has risen exponentially to meet the ever-increasing population growth of mega-cities. These trends have resulted in a dramatic rise in groundwater pumping and associated high rates of aquifer depletion around the globe. The depletion of our world’s aquifers is unsustainable and will eventually impact the food security of future generations. Also, groundwater depletion results in severe environmental impacts such as land subsidence, groundwater salinisation, and damage to groundwater-dependent ecosystems.  Despite decades of research on groundwater overuse, knowledge on attainable groundwater reserves and the critical time horizons of their depletion is completely lacking. In GEOWAT, I propose to take the giant leap to extractable volumes and depletion horizons by answering the obvious question that has been avoided thus far: How much groundwater is there and how long will it last?  To this end, my research team will build the first high-resolution global groundwater model supported with a 3D-mapping of the world’s aquifers. We will use these unique modelling tools, in combination with dedicated case studies, to assess, for the first time, the global volume of physically and economically extractable fresh groundwater, and determine the time to physical and economic depletion under future pumping. We will also provide the first global assessment of the effects of groundwater pumping on groundwater-dependent ecosystems and explore pathways to sustainable groundwater use. As such, GEOWAT w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhancing Cancer Vaccine Science for New Therapy Pathways' (CANVAS).

assistant: **Innovation**

The main objective of the project Enhancing Cancer Vaccine Science for New Therapy Pathways (CANVAS) is to significantly raise the scientific profile, networking, and research management competencies at the International Centre for Cancer Vaccine Science (ICCVS) at the University of Gdańsk (UG), Poland, to achieve improved research excellence in cancer vaccine science. The project aims to contribute to reduction of the disparities in R&I in Europe by networking activities with outstanding leading European research partners: University of Rome Tor Vergata (UNITOV), Italy, and Alternative Energies and Atomic Energy Commission (CEA), France. The partnership includes also a biotech start-up Real Research (Poland), to foster intersectoral knowledge transfer for innovative translational research approaches. A strong focus on upgrade of grant writing and research management skills will improve long-term competitiveness in obtaining funding. In addition a joint pilot study is planned in the project. We expect that it will provide the foundation for a novel patient tailored therapy of non-small cell lung cancer. Thus, apart from the scientific impact, in the long term innovations generated with the support of the CANVAS partnership have a translational potential to contribute to improving therapy for cancer patients, which give the project a pivotal economic and societal impact.


**Keywords:** Increasing scientific, collaborative and management competencies, immunopeptidome, cancer immunotherapy, T cells, PDX model, 3D cell culture, computational immunology, mass cytometry