RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New additives to prevent migration of foreign species contained in ballast water and harmful effects of antifouling paints containing tributyltin' under Fifth Framework.

assistant: **Concept**

Europe is facing a huge environmental problem in preserving the ocean and river ecosystems. Firstly, ships travelling around the world introduce non indigenous and harmful organisms and microorganisms contained in ballast water. This causes major risks to the preservation of ecosystems and the sustainable use of coastal resources. Secondly, hull protecting chemical (tributyltin or TBT) contained in anti fouling paints for ships have been found to cause severe environmental damage to non target organisms (marine species). Therefore, the objective of the proposed project is to develop a new range of non toxic additives to introduce in paints and ballast capable of solving these two majors and linked problems in killing harmful organisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Ex-situ bioremediation of petroleum-contaminated sands using hydrocarbon-degrading marine microbes'.

assistant: **Objectives**

In this project, the primary goal is to optimize slurry phase bioremediation of petroleum-contaminated sands using marine bacteria. Optimal cultivation conditions for hydrocarbonoclastic bacteria will be determined by varying the medium composition (ratio of carbon, nitrogen, phosphorus and potassium), the solubility ofalkanes/PAHs in water (supplementation with biosurfactants) and other parameters (pH, temperature & dissolved oxygen). Specific growth rates and intrinsic degradation rates of selected isolates and communities will be measured in the absence of the soil matrix (sand). The intrinsic rates will be compared to mass transfer resistances for different types of oil and different conditions of mixing, and an expression for the overall degradation rates will be derived for a variety of nutrient availability situations by conducting an extensive series of experiments in slurry phase bioreactors. The performance of this system with marine bacteria will be compared to typical heterotopy oil-degrading microbes of terrestrial origin. The experimental data will also be used to develop a mechanistic mathematical model. The Marie-Curie Fellows should have a Ph.D. in Biochemical Engineering or equivalent and a good publication record as well as expertise in slurry phase bioreactors. The Fellows are expected to carry out innovative ex-site bioremediation research and collaborate with staff members in the laboratory. Excellent knowledge of the English language is required. At the time of selection, the Fellows must be 35 years old or less (allowance is made for childcare or military/civil service) and cannot be of Greek nationality or having worked for more than 12 months during the past two years in Greece. The work will be carried out at the Laboratory of Biochemical Engi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'HARmonised PracticEs, Regulations and Standards in waste management and decommissioning'.

assistant: **Innovation**

The project aims to establish and clarify the benefits and added value of more aligned and harmonised regulations and standards for prioritised topics related to decommissioning and initial phases of radioactive waste handling, including shared processing facilities between Member States (MS).The project has a two-phase approach: first engaging with Stakeholders to assess needs and pros/cons for harmonisation and identify priority areas for deeper analysis (WP2). The second phase will pursue deeper engagement with Stakeholders to further assess the highest ranked priority areas in Work Packages (WP) focusing on (i) cross border services and cooperation (WP3), (ii) circular economy (WP4), and (iii) advanced technologies (WP5). These WPs will review (inter)national practices, capture lessons learned, and assess opportunities. WP6 on Regulatory Framework will identify regulatory differences between MS and evaluate strengths, weaknesses, opportunities, and threats associated with harmonisation, while quantifying the benefits of aligned regulations and proposing harmonisation methodologies. The project will:- support coordination between Stakeholders, - enhance existing commitments to facilitate sharing and exchange of knowledge and experience, - develop strategies for shared treatment and storage facilities, cross border services and cooperation, and explore additional mechanisms to build capacity in MS, - assess and clarify the benefits and any disadvantages of harmonisation,- deliver S&T-based solutions and share best practices by engaging and supporting coordination between different actors through the TSOs and regulators, - define conditions and opportunities of a high safety circular economy.The action will reinforce the activities of the EURAD, PREDIS, and SHARE proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The formation of Europe prehistoric population dynamics and the roots of socio cultural diversity' under Sixth Framework.

assistant: **Concept**

Our major goal is to test with quantitative and qualitative tools the hypothesis that some key aspects of the current economic and socio cultural diversity of European nations have roots in prehistory. We shall integrate the expertise in mathematics computing archaeology palaeodemography and palaeoenvironment into an interdisciplinary approach aimed at a groundbreaking comprehensive theory of the Neolithic Revolution. We shall quantify and hence clarify the interaction of the environmental factors with social cultural and human aspects of the Neolithic Revolution.This project will be the first to consider the Neolithisation of Western Central and Eastern Europe as a pan European process. Our main tool will be a novel mathematical model of population dynamics for the epoch of the initial spread of the Neolithic in Europe 8000 - 3000 BC.The model will be based on advanced population dynamics theory with full allowance for environmental factors including geomorphology waterways and coastlines soil fertility and biomass and climatic variations.The methodology of parameter estimation for large scale population dynamics models will be developed and various mathematical and geostatistical approaches to local and non local demographic processes will be implemented.The model will be refined using the abundant radiocarbon age determinations genetic markers and archaeological evidence. Much of the high resolution archaeological evidence will be collected in several case studies focussed on the Adriatic Sea area the Eastern Balkans Central and Eastern Europe.Our results may significantly change the understanding of the origin and nature of modern cultural social and economic diversity in Europe. We anticipate that this project will develop into a new field of research Quantitative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel material for watch crystals and watch cases: Mg-spinel transparent ceramics'.

assistant: **Concept**

Watch companies over the last century have continuously experimented with watch materials: from precious metals to simple plastics, watches can be made out of almost anything. Consumers’ expectation from a watch is now not only just for timekeeping but also for their craftsmanship, appeal and design. Therefore, a fresh scratch on an otherwise flawless crystal is a devastating sight for such a watch user. The feeling can be even worse on a brand-new watch, or one that just returned from servicing. The growing preferences of mid & high-range branded watches are therefore contributing significantly to the timepiece demand almost all around the world and Europe is still leading the market as the heart of the watch industry. Thus, vendors have to keep up with the trends by introducing innovative products/parts to satisfy the various needs of the customers. Watch crystals and watch cases are unquestionably important parts since they protect the sensitive working mechanism from the external effects. We are now proposing a novel yet promising approach so as to use transparent ceramics (TCs) as scratch resistant watch crystal and case.Our technology is unique in a way that this hi-tech TC material (Mg-spinel ) is applied to watch crystal & case market. Mag-Spin has built-in advantages over the transparent materials such as acrylic (plexiglass), mineral glass and sapphire used for watches. Mag-Spin is highly durable in extreme conditions and hardly possible to be scratched in everyday use. Our ability to introduce embedded design and colour and to customize the level of transparency also make it suitable material to be used in elegant and fashionable timepiece products. On top of it, unlike sapphire, Mag-Spin’s microstructure allows future improvements from the scientific & engin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Gravity perception: molecular, cellular and adaptive behavior' under Horizon Europe.

assistant: **Concept**

Although gravity sensation is not easy to sense, it is extrapolated by combining multisensory information. Due to this integrative nature of gravity perception, the knowledge regarding the molecular and neural basis of gravity sensing is highly reduced. The relevance of geotaxis behaviors in insect pest crop survival has been well documented. For instance, harvesting maize imposes a positive geotaxis behavior on the European corn borer (Ostrinia nubilalis), where diapause larvae and pupae are found close to the ground (contrary to what is observed in wild conditions). This adaptive behavior increases its survival and, indeed, its agricultural damage. In addition, larvae show a stereotype orientation when diapausing, suggesting that gravity vector plays a critical role in maggot spatial perception and physiology. In Drosophila, a well-studied insect genetic model, the maggot has a positive geotaxis at early stages, which changes to negative geotaxis at the wandering time (prepupariation period). However, magot gravity perception has never been confirmed or studied. Interestingly, wandering larvae exit the food source searching for an appropriate pupation site, displaying body position and orientation changes. Herein, I propose to take advantage of wandering orientation changes to set up a novel geotaxis behavioral assay and disclose gravity sensory modality in the maggot by i) screening for sensory organs involved in gravity sensing, ii) disclosing the neurocircuitry involved in puparium orientation behavior, and iii) studying the consequences of puparium orientation alteration on adult fitness. I expect this exploratory proposal to establish a solid basis for working further in the physiological impact of insect spatial orientation and the practical use of this knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'An Artificially Intelligent Diagnostic Assistant for gastric inflammation' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Most cases of gastric cancer (GC) are detected at a late stage, when patients have a median life expectancy of about a year. Diagnosing people at risk of developing GC at the pre-symptomatic stage, typically chronic gastric inflammation, could significantly improve the outlook.Artificial intelligence (AI) can help clinicians make sense of their own data by automating much of the treatment and analysis, which require manual work and years of experience. But it can do more: it can bring together available data from various sources into a vast data lake and cross-correlate the data to derive a ‘risk score’ for gastric cancer and shed light on the mechanisms of its evolution.Aida aims to do just that. It helps researchers understand the mechanisms that trigger gastric oncogenesis, helps clinicians diagnose precancerous inflammation at the earliest possible stage, suggests personalised therapeutic strategies for treatment and follow-up, and makes personalised recommendations for monitoring patient health status, thus contributing to gastric cancer prevention.This places Aida squarely on Europe’s agenda of ‘Staying healthy in a rapidly changing society’. Aida unites some of Europe’s leading authorities in the field of gastric inflammation, gastric cancer, leading AI and machine learning experts, experts on data governance and privacy, representatives of the public administration and patient advocates. Aida also has strong ties with the industry.After the project, the results will live on in an association that acts as a transnational focal point for chronic gastric inflammation — and GC in general. We hope that the solid, inclusive design principles of Aida, its societal relevance and its durability will spawn a vigorous ecosystem around chronic gastric inflammation, its unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Co-firing of biomass, coal waste and coal in mining sites for electricity generation' to be submitted under Fourth Framework.

assistant: **Abstract**

PROJECT OBJECTIVES Co-firing biomass with coal in an existing coal plant is a way to use biomass with a substantial efficiency and replace coal at limited cost. Biomass could be a major alternative for locally mined coal given the expected large potential, together with the environmental benefits of cleaner biomass, and employment in coal mining areas, including advantages mainly like: i) no new generating capacity is needed, ii) reduction of CO2 and SO2 emissions, iii) utilization of local resources such forest residues, iv) generation of local employment. Within this framework, the objective of the project is to carry out a study to determine the possibilities of co-firing of biomass (mostly forestry and sawdust residues) with coal and coal waste from mining sites in Narcea I, 65 Mwe coal fulled plant sited in Tineo (Asturias - Spain). The main relevance of the project is to increase sharing of renewable in the energy system, to reduce fossil fuel use and to reduce environmental impact while at the same time using local resources with major benefits for the local economy. TECHNICAL APPROACH Within the development of the project, some tests at different scales will be carried out. At labscale, an entrained-flow reactor will be used in order to get an extensive characterization of coal, biomass and coal-waste combustion. This facility has been designed to some of the relevant parameters in a power-plant boiler (temperature up to 1 500 C, residence time up to 3 seconds), in order to simulate the particle combustion histories. On the other hand, a close control of the test variables can be achieved (co-flow gas composition, temperature profile, residence time), allowing a systematic investigation of the combustion behavior of solid fuels. At semi-industrial scale, combust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European project for the development of HTR technology - materials for the high temperature reactor' (HTR-M1).

assistant: **Innovation**

The development of Advanced High Temperature Reactor (HTR) concepts requires material data information and an understanding of material behaviour under react or operating conditions and environment. For components important to the safety and feasibility of modular designs such as the turbine and the graphite structures (core), investigation of the different materials to be used with respect to long term damage and behaviour in the reactor environment is necessary.This work identifies and investigates the most promising materials in these areas with respect to time dependent damage and behaviour and provides information that can be used for feasibility investigations of the most promising options for future application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Prostate cancer extracellular vesicles as biomarkers for nanomedicine treatment' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Prostate cancer (PC) is one of the deadliest types of cancer in males worldwide. Early stage PC is often curable but many patients develop castration-resistant prostate cancer (CRPC), resulting in lethal end-stage disease. Prostate specific antigen (PSA) plasma levels have been traditionally exploited for diagnosis and prognosis. However, the application of PSA as a biomarker is associated with predictability issues. Advanced therapies are required for the treatment of CRPC, guided by a reliable companion diagnostic (CDx) test to monitor therapeutic efficacy. The aim of “PREVENT” is to co-develop a nanomedicine-based combination therapy for the treatment of CRPC and a CDx based on extracellular vesicles (EVs). I will employ tumour-targeted nanomedicines to deliver more drug to the tumour and reduce side effects when compared to free drug. The treatment comprises microfluidics-prepared lipid nanoparticles (LNPs) containing siRNAs that target genes involved in CRPC and LNPs loaded with the cytotoxic anti-cancer agent docetaxel to achieve synergistic therapeutic effects. For the CDx test, extracellular vesicles (EVs) have created excitement as possible biomarker candidates. EVs are released by cells as means of intercellular communication and can be detected in bodily fluids. The number of EVs and their composition is altered in CRPC, raising opportunities to exploit them in a CDx test. As EVs provide a fingerprint of their parental cell, EVs can be considered liquid biopsies, providing more information than standard biomarker measurements, and much less invasive than prostate biopsies. I will collect blood and urine samples during the preclinical evaluation of the proposed treatment for analysis using immunocapture and flow cytometry-based immunodetection platforms. The c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NatureCOLOURS: Natural colours delivered by yeast fermentation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Colour is an essential characteristic of food, associated with quality, freshness, and taste perception. Natural and synthetic food dyesare added to processed foods to enhance or correct variations and give an expected colour to colourless foods, such as soft drinks orcandies. Many synthetic colours cause hyperactivity in children, trigger hypersensitivity reactions, and some are carcinogenic in animalstudies. Natural colours do not have such adverse effects and are even health-promoting. While natural colours are in high demand,their natural sources are limited.The goal of NatureCOLOURS project is to create a novel technology for making natural colours by yeast fermentation. The projectwill bring a pallet of natural colours with health-beneficial effects to the consumer, create new industrial processes and new jobs inEurope, and contribute to the sustainable bioeconomy.