RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Totally integrated micro-engineered ion sensors for large scale applications'.

assistant: **Innovation**

The overall objective of this project is to research and develop a novel family of autonomous analytical instruments to be used to in-situ water monitoring of ammonia/ammonium content. Monitoring of ammonia/ammonium content has been chosen as a generic practically important task with a wide potential market. Prototypes developed on this project will be subject to end user field trials in real environmental application areas (coastal and estuarine waters, fresh water, waste water, industrial effluents, landfills) at various geographical test sites in different EU countries using different deployment scenarios. This project follows a first phase which demonstrated the efficacy of totally integrated Ion-Selective Conductometric Microsensors (ISCOM) and Durable ISCOM (DISCOM); further developments of these microsensors will be used as the components for the prototype analytical instruments demonstrated on this project.The project will develop a number of new system components for autonomous analytical instruments, which include smart sensor units with embedded components, such as valves, filters and pumps as well as redundancy and intelligent features to accommodate the industrial requirements for quality and durability. The development of the technical means and respective fabrication technologies for the new system components, together with the systems integration, form the major part of this project.The need for new sensor systems is largely driven by environmental legislation, which requires the increasingly stringent measurement and control of water quality. Current measurement systems are expensive to operate and maintain, restrict the number of analysed samples, and do not permit real-time monitoring as demanded by industry. In situ deployment of existing fixed-site
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neuromicronica: Modular behavioural neuroscience', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Neurological disorders, particularly dementia, constitute arguably the greatest socioeconomic challenge to the aging European continent. There is growing realization that rodents can serve as models not just for basic neurobiological processes (e.g. synaptic transmission) but also for remarkably complex, primate-like and even human-like cognitive operations such as perception, memory, economics, social interaction, and decision making. Better rodent models for cognition are necessary to test theories on the molecular basis of neurological disorders and to test therapies: only through rodent behavioral neuroscience can the circuits that give rise to cognitive operations be examined and dissected, probed and manipulated. The aim of ERC Advanced Project ‘CONCEPT’ is to understand the neuronal bases of perception, memory and decision making. To achieve this aim, we have developed innovative instrumentation incorporating the following elements: (i) awake rodent interacting with its environment, (ii) precisely controlled sensory stimuli, (iii) imaging of animal’s action, (iv) electrophysiology with moveable microelectrode arrays, (v) optogenetics, (vi) integration and management of all incoming and outgoing signals. Here, we present our plan for bringing these instruments to a stage where they can constitute the initial product line for a spin-off named NeuroMicronica. The community’s interest in NeuroMicronica is already testified by the commercialization of the electrode drive in agreement with a prestigious USA company, by NeuroMicronica’s selection in a technology startup competition, and by the enthusiastic and constructive feedback from collaborators now employing beta versions. The expected outcome of NeuroMicronica will be to make this lab’s longstanding experience in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cosmic ray acceleration, magnetic field and radiation hydrodynamics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Diffusive shock acceleration is widely acknowledged as the most likely source of cosmic rays and high energy particles. The basic macroscopic theory of how cosmic rays gain energy during multiple shock crossings is well known, but the microphysics of the interaction between cosmic rays (CR) and the MHD background fluid remained poorly understood before the recent discovery of a new non-resonant instability by which the CR precursor could greatly amplify the ambient magnetic field. The aims of the project are: 1) to develop the first self-consistent non-linear simulation of the CR/MHD interaction; to calculate the magnitude of the saturated magnetic field and the maximum energy to which CR are accelerated. We will characterise the structure of the amplified magnetic field and compare it with x-ray observations of the time-evolving outer shock of supernova remnants (SNR). We will investigate the effect of various orientations of the shock relative to the ambient magnetic field, the effect of non-diffusive transport on the energy spectrum and CR escape from the SNR, and how these match observation. 2) to extend the simulation to relativistic shocks as found in gamma-ray bursts (GRB) and active galactic nuclei (AGN); to establish whether the non-resonant instability operates effectively at relativistic shock velocities, whether it explains the large magnetic field found in GRB, and determine the maximum CR energy achieved by relativistic shocks. 3) to investigate high density shocks in GRB, x-ray flashes (XRF) and supernovae (SN) where radiative processes, pair production and other particle/photon and particle/particle interactions are important. We shall investigate CR acceleration on SN shock breakout and very young SNR as a possible source of very high energy CR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new Business Model for the Natural Cosmetic market'.

assistant: **Concept**

LaboPhyto is an Italian SME dealing with the manufacturing of naturals products for cosmetics brands – big and small ones. The CosMyFY project aims at developing a new business model oriented to the implementation of own brands and own direct market. Current business model is limited, in terms of growing capability, by traditional clients and their business models. In the natural cosmetics market new player are emerging, offering own brands and working with social network (actually blogs). They are individuals, mainly women, who become « blog lead » and boost number of followers exceeding millions. The great advantage in bloggers’ approach is the direct and complete engagement of the followers both in the product choice (colour, type, functionality) and in its diffusion by the contact chain. Bloggers, however, lack production capability. LPT has his own know how and production capability that will allow to overcome this current market weakness and to aggregate many blogger to implement a new business. This new model will shorten the value chain, improve GM, reduce environmental impact, create new employment and new widespread business opportunities. In the project a local customized production capability is envisaged by adopting local 3D printers, both by the blogger and by associated shops. This step will represent a real disrupting innovation in the market. At the end we will have: A business plan development; The platform COSMYFY integrating technologies (3D printers included), products and bloggers database, Assessed the world market and established a bloggers-own label producers network, Defined a plan for marketing and business development. Pilot application  of the new business model built, tested and validated. For the realization of the objective we foresee: A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In situ structural basis of human axonopathies' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Myelinated axons propagate action potentials across otherwise unsurmountable distances. The overarching hypothesis of the cryoNERVE project is that membrane morphology crucially determines axonal health and function. Mutations in genes coding for membrane-shaping proteins are the major cause of familial axonopathies like hereditary spastic paraplegia (HSP) and Charcot-Marie-Tooth (CMT) disease. However, current techniques lack the resolution to ascertain the functions of these proteins and their pathological dysfunction within native nerves. At the same time, the highly specialized architecture of axons and their delicate interplay with glia can only be studied in situ.I have shown how cryo-electron tomography (cryo-ET) reveals the structural basis of neuronal function and disease within intact cells. However, cryo-ET imaging of tissues remains a major challenge. In cryoNERVE, we will develop cryo-ET workflows to image native nerve tissue at unprecedented resolution. We will build on these advances to study the function of HSP and CMT proteins within truly physiological environments. Specifically, we will investigate (i) how these proteins shape axonal organelles and their cross-talk, (ii) the mechanisms allowing myelin sheath formation and neuron-glia communication, and (iii) the alterations introduced by axonopathy-causing mutants.Lastly, we will pioneer the first cryo-ET analyses of vitrified human tissues. Frustratingly, peripheral nerve biopsies from axonopathy patients often cannot be diagnosed with existing methods. We will examine patient biopsies at molecular resolution, and capitalize on our findings in flies and mice to reveal hitherto obscured pathological abnormalities. Thus, cryoNERVE will provide a holistic molecular and structural basis of human axonopat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Postimperial Memories, Gender and Trauma in the Anthropocene: A Change of Feminist Perspective on Turkey' to be submitted under Horizon 2020.

assistant: **Abstract**

The increasing currency of the Anthropocene era demands new ways of thinking about grief and trauma which are both personal and cultural experiences. As E. Ann Kaplan proposes, the concept of “pre-traumatic stress syndrome” describes how cultural representations of accelerated environmental degradation generate “climate trauma,” which is accompanied by its own psychological condition (2015). Further, a host of slowly unfolding environmental crises confront us with “slow violence,” which is neither sudden nor spectacular but instead incremental with calamitous repercussions for years or decades or centuries. Much of the current narrative on the Anthropocentric age relies on the realm of Western and European from human-centered, techno-focused, and masculinist lens, overlooking the feminist roots of work on the Anthropocene. This novel project proposes feminist and queer study of Anthropocene trauma in post-imperial Turkey and its European diasporas by investigating how public intellectuals remember and dramatize grief and trauma regarding the lingering environmental effects of the Ottoman Empire, the environmental aftermath of war and genocide, climate trauma, and other forms of slow violence in modern Turkish literature. Divided into five work packages, the objectives of this project can be synthesized as follows: mobilizing a new taxonomy of trauma and grief in contemporary Turkey pertinent to the Anthropocene; developing feminist and queer forms of insight into the Anthropocene conversation through post-Ottoman context; being the first of its kind that simultaneously acknowledges and transcends current environmental concerns and one that relates back to gender, race, ethnicity, and class in Turkey and its European diasporas. This project corresponds well with 2020 EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional genomics of pancreatic beta cells and of tissues involved in control of the endocrine pancreas for prevention and treatment of type 2 diabetes' (EURODIA).

assistant: **Concept**

Failure of pancreatic beta cells to maintain adequate functional capacity leads to increasing blood glucose levels and subsequent type 2 diabetes (T2DM). This disease imposes a huge, and growing, socio-economic burden on European and global societies. However, the pathophysiological mechanisms underlying beta cell dysfunction remain poorly understood, limiting the availability of novel approaches to treat or prevent T2DM.Here, we propose an Integrated Project that will lead to an unprecedented understanding of the factors influencing the maintenance (and loss) of normal beta cell functional capacity. This will be realized through the application of functional genomics technologies in an integrated and systematic approach, which employs studies in cellular and animal models as well as genetic analysis of human monogenie and polygenic T2DM patients. The project will integrate leading European experts in islet diabetes research, human geneticists, bioinformaticians and computational scientists as well as SMEs.Specific aims will be to:- Dissect the molecular pathways and identify key regulatory events - including those contributed by tissues located outside the endocrine pancreas - that control the ability of the beta cell to maintain its secretory function over a lifetime.- Identify key pathophysiological events in the above pathways that become dysfunctional in T2DM and determine the contributions of lipotoxicity, glucotoxicity, oxidative stress and me impact of genetic variations in the induced beta cell dysfunction.- Select genes and proteins that are candidates in the pathogenesis of beta cell dysfunction and assess their physiological role and potential value as novel drug targets for prevention and treatment of T2D.Collectively this program will lead to an unpreceden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Spontaneous T cell responses against cancer neoantigens'.

assistant: **Innovation**

An old question in tumor immunology is whether cancer cells can spontaneously activate T cells that in turn destroy them, termed immunosurveillance. While firmly established for virus-associated tumors, immunosurveillance of spontaneous tumors is still controversial. Intuitively, autochthonous cancer models may be better suited than transplantation model to address this question, yet current models bear pitfalls and do not resemble the sporadic nature of human cancer. Importantly, they are not conclusive. Cancer cell transplantation is artificial and induces acute inflammation, facilitating T cell activation. It may be suited, however, if tumor antigen expression and cell proliferation can be regulated and induced when resting conditions have been re-established.We will investigate, in two novel cancer models, the fate of T cells specific for naturally occurring mouse and human neoantigens under resting conditions, resembling pathophysiologic conditions. We hypothesize that induction of a large foreign antigen harboring several epitopes, but not a mouse point-mutant neoantigen, activate functional T cells under resting conditions, while both will do under acute inflammatory conditions. We further conditionally express human mutations, either proven or predicted neoantigens, in cancer cells syngeneic to mice with a diverse human T cell receptor repertoire restricted to HLA-A2. Our studies will answer the questions, whether the initial antigen encounter induces functional or dysfunctional T cells, what distinguishes antigens that can or cannot induce functional T cells, what is the long-term fate of the T cells, why are spontaneous T cell responses rare relative to mutation load and how precisely can neoantigens be predicted. This project will clarify the role of immunosu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plasma & membrane supported catalytic gasoline fuel processor using hydrogen selectic membrans (PMFP)' (PMFP) under Fifth Framework.

assistant: **Objectives**

Objectives and problems to be solved:Fuel cell based propulsion systems can help effectively to reduce environmental impacts of mobility. Availability of hydrogen now is one of the most important problems hampering their broad application. The project objective is to develop a new approach of covering gasoline to hydrogen, based on plasma and membrane supported gasoline reformer for on-board hydrogen generation, with high energy density, very high efficiency and flexible operation for fuel cell driven cars. Plasma reactors and membrane modules are to be developed and integrated in a bench demonstrator of the fuel processor for performance evaluation of this approach.Description of work:Two different plasma technologies with low temperature microwave torch and a gliding arc torch will be developed in the project. Together with the membrane modules for separating hydrogen from the reaction gas, the plasma generators are integrated in a bench demonstrator. The power range is defined with a maximum fuel input of 40 kW. The results will be tested and evaluated in a realistic model, against a set of evaluation criteria including: energy efficiency, power density and transient response. The problems addressed through this project are relevant for the automotive industry in Europe as a whole. These problems are addressed in an interdisciplinary approach by a consortium of five partners from four countries with excellent complementary competencies, including a leading automotive firm, a word leading membrane supplier, an innovative SME supplier of microwave plasma reactors, a plasma physics institute and an applied research institute with key expertise in plasma catalytic gasoline reforming. The PMFP will be developed primarily for automotive propulsion systems with first applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'On-Demand Bioresorbable OptoElectronic System for In-Vivo and In-Situ Monitoring of Chemotherapeutic Drugs' in the context of a Horizon Europe call.

assistant: **Objectives**

We envision a radically new technology for in-vivo bioresorbable chemical sensing, where optical devices, power and light sources, synthetic receptors - made out of materials that completely dissolve with biologically benign byproducts in biofluids - will be developed and integrated together. The sensing system, the size of 1 EuroCent, will be coated by a long-lived biocompatible polymer designed with on-demand degradation, then implanted in the body to monitor in-vivo, in-situ, and in real-time a chemotherapeutic drug, doxorubicin, commonly used to treat cancer; the system is then fully and safely RESORBed once no more needed using an external temperature-trigger that initiates the dissolution of the protecting coating and, in turn, of the system, avoiding device-retrieval surgery that may cause tissue lesion/infection. The general objective is to demonstrate fabrication, operation (2 months) in-vivo and in real-time - then dissolution - of such a bioresorbable chemical sensing system for the detection of doxorubicin in an animal model. This will break a new ground in in-situ monitoring of chemotherapeutic drug enabling – for the first time – a fine tuning of the drug dose at the tumor site, increasing patient survival rate. Being aware of the project risks, we have broken down the general into different specific objectives, identified a set of Key Performance Indicators, alternative material synthesis/device fabrication techniques, mitigation measures to tackle major risks. The RESORB technology truly represents the foundation of a future technology for personalized medicine, enabling to address a number of medical issues for which continuous and localized monitoring of specific analytes (i.e., biomarkers and drugs) in-vivo for a prescribed time is of chief importance