RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A non-antibiotic treatment for Acne and Onychomycosis'.

assistant: **Objectives**

Acne and onychomycosis (nail fungal infection) are two of the most common skin diseases, affecting up to 90% of teenagers and 10% of adults, respectively. Acne is estimated to affect 9.4% of the global population, making it the eighth most prevalent disease worldwide. In addition to the health and cosmetic damage, there are psycological consequences for these patients, which have a great negative impact in quality of life. The current treatments for these diseases have limitations in terms of efficiency and side effects as well as containing antibiotics. As a result, there is poor patient adherence to these therapies contributing to increase the microbial resistance, a matter of great concern for global society. In response to this challenge, Mavena has developed innovative medical devices (Green Line) for the treatment of acne and onychomycosis. Green Line uses a novel concentrate of peracids which destroy bacteria, fungi and viruses thorugh a physical process. Green Line’s mayor advantages are its high efficacy compared to current solutions and the absence of antibiotics, improving therapy adherence and reducing the risk of microbial resistance. Green Line will be notfied as class III medical devices, and thus do not need such a long and difficult approval process as for a medicinal product. Moreover, after notification, Green Line medical devices can be sold within the whole European Community and do not require prescription. This reduces the time to the market and opens a large territory at once. Upon completion of the project, this solution will boost the growth of our company generating additional 13 FTEs, revenues of €65.1 M and a ROI of 7.48 by the fourth year after Phase 2 execution. With the help of the SME instrument, Mavena aims to complete the clinical vali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Empirical Models of the Euro Economy' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The proposed Euro Conference consists of two meetings intended to bring together researchers developing macroeconomic models of the euro area for a set of simulation and policy evaluation exercises designed to facilitate the comparison between the models. Macroeconomic models are important and established tools for informed decision-making in public policy and the private sector. The start of EMU has created a new economic and financial environment in Europe. As a result, existing models of the member economies have become inappropriate to guide decisions, as some key variables such as inflation and interest rates no longer have a national content in the EMU, while the behaviour and interrelations of others such as employment and output will change due to the vanishing of currency borders in Europe. There is, therefore, an urgent need for developing new tools for policy evaluation, for simulating alternative policy scenarios, and for forecasting.The purpose of the first conference is to promote research efforts aiming at the development of macroeconomic models of the euro area. This will be achieved by bringing together researchers involved in such efforts for a comparison of their models based on a unified framework. Similar comparison exercises have been conducted successfully in the US and in the UK, but never in the EU. The first meeting in the proposed series will compare and evaluate models of the euro area focusing on the aggregate performance of the economy. Researchers will be asked to perform simulations based on a common set of assumptions concerning monetary and fiscal policy in the euro area and external shocks. The results will be used to compare what the models say about the reaction of the euro economy to monetary and fiscal policies and external shocks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Frequency Combs Quantum Metrology' in the context of a Seventh Framework call.

assistant: **Objectives**

Optical frequency combs are extraordinary tools for metrology which have been recently crowned by a Nobel prize: they have replaced complicated frequency chains to perform direct frequency and time measurements with much higher accuracy, which is now getting close to the quantum limit. However, quantum aspects of measurements performed with these sources have not yet been studied. This is the subject of this proposal. Based on model experiments such as space-time positioning, dispersion, velocity or frequency measurements, we propose to assess and reach experimentally ultimate limits derived from information theory in presence of quantum noise. We also propose to go beyond these limits using non-classical states. More specifically, we propose to fulfil the following objectives :  Objective 1 : achieve the best absolute space-time positioning sensitivity ever using quantum optics techniques applied to frequency combs. " Objective 2 : apply those techniques to other high sensitivity measurement such as dispersion, velocity or frequency metrology. " Objective 3 : explore fundamental quantum physics effects in the lab with quantum frequency combs. These tasks will be performed by developing a quantum frequency comb factory, based on mode locked laser sources and parametric oscillators, whose conception is a research line in itself, and that would also be used for new quantum states generation such as macroscopic entanglement and multimode states."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PROgrade metamorphism MOdeling: a new petrochronological and compuTING framework'.

assistant: **Objectives**

Prograde metamorphism produces large amounts of fluids that have an important role for earthquake generation, arc magmatism, the growth of continental crust and for global geochemical cycles. Despite recent efforts, it remains challenging to recognize and quantify fluid fluxes in natural rocks and to model fluid pathways. The existing petrological modeling techniques are all based on the thermodynamic analysis of single rock types and neglect the chemical changes caused by fluid expulsion and the possible interactions with other rocks. The next frontier in metamorphic petrology is therefore to move our modeling capabilities from an isolated single rock system to an open and multi rock system, in which fluids can flow in, react and flow out. This concept introduces several challenges from the quantification of fluid-rock interactions in natural samples to the integration of aqueous thermodynamics and fluid dynamics in the petrological models. Based on the developments of high-resolution techniques such as quantitative compositional mapping, I have demonstrated that the petrological models can be inverted to quantify prograde metamorphism based on preserved mineral relics that partially re-equilibrated in the presence of fluids. The primary objective of PROMOTING is to develop a brand-new framework for petrological modeling of fluid-rock interactions in different, coupled rock types during prograde metamorphism. The models will be calibrated on two key tectonic settings that shaped Earth: subduction of oceanic crust and differentiation of the continental crust. A cutting-edge petrochronological strategy is required to identify at which conditions and when fluid-rock interactions occurred in natural rocks. The outcomes of this project will not only form the basis for a new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Combustion chemistry of novel ultra-clean potential diesel fuels (CLEANBURN)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Experienced researchers are required with a good background in spectroscopic techniques to characterise the formation of transient species in the gas -phase produced during the burning process either in our shock tube or our rapid compression machine. In house we have competence in the experimental techniques and in the chemical kinetic modelling and simulation of experiments. Together we would like to apply this integrated knowledge into the design and execution of experiments using our newly built shock tube and recently purchased, intensified charge-coupled detector + spectrograph which might shed light on the appearance of the emission spectra characteristic of potassium atoms (an impurity present in extremely low background concentration) and how their formation correlates with the formation of other expected species, such as C2, OH, etc. produced during pyrolytic or oxidative reactions of organic compounds some of which are potential ultra-clean, low molecular weight, diesel fuels such as dimethoxymethane. Thus emission from K atoms may serve as a useful marker of the combustion chemistry. Additional experiments will explore the fine structure of the emission bands from excited electronic states of OH to determine the temperature of the shock wave and the temperature evolution with time of the reacting mixture. Also the design &operation of an TN-VIS absorption CCD spectrograph and a high-speed IR detector in conjunction with the iCCD emission spectrometer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ELITRANS-Facilitating the transformation of ELI from ERDF funded, distributed infrastructures towards a unified ELI-ERIC.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

While the implementation of the “Extreme Light Infrastructure” ELI is nearing completion in Czech Republic, Hungary and Romania, its remaining goal is to create the necessary conditions for the future operation as a single, distributed international laser user facility of pan-European dimension. The scope of the present ELITRANS project is to complement the final implementation stage by preparing and undertaking the transformation from three legally (but not conceptually) independent construction projects towards operation as a single international legal entity, ELI-ERIC.The main objectives are:• Conceptual Design of the future ELI-ERIC’s “Business Model”: essential elements of the future ELI-ERIC organization, financing, governance and international integration • Preparing ELI-ERIC’s “Business Plan”: development of concepts adapted to the operation as the world’s first international laser user facility • Managing the transition from Structural Funds supported implementation towards ERIC-funded operation: merging the three facilities into one unified internal structure, developing a corporate identity, strengthening user relations, developing the scientific profile, international visibility and leadershipThe proposed actions are structured in eleven Work Packages. They cover the majority of activities considered necessary by the Commission for a successful implementation of ESFRI projects, and take into account specific recommendations by the ESFRI  Assessment Expert Group. The objectives shall be achieved through concepts jointly developed with European and international partner facilities, and world-leading e-infrastructures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Concepts for integrated transboundary water management and sustainable socio-economic development in the cross border region of Albania, Former Yugoslav Republic of Macedonia (FYROM) and Greece'.

assistant: **Concept**

The TRABOREMA Project will stabilise and reinforce research potential in the field of integrated management of regional water resources planning and policy in a transboundary lake region between Albania, FYROM and Greece. Using the EU Water Framework Directive as a guideline, the Consortium, which also includes universities specialised in environmental issues from Austria and Spain, will design and implement a monitoring system in the catchment to Lake Prespa. Together they will research upstream/downstream water user demands to determine environmental pressures and impacts in terms of ecological quality ratios (EQR) for the target region. This data will be modelled and simulated using state of the art computer applications to make predictions and perform scenarios. The results will be analysed and used as a basis for transboundary policy recommendations for integrated management of the water resources and sustainable socio economic development of the region. The strategic objectives of the TRABOREMA Project are: LForm successful and enduring partnerships within the consortium and to interested parties such as authorities, policy makers and public participants within countries of the target region and to EU member states to help settle political and social situation in the Western Balkans. 2.Communicate the importance of integrated water management (which incorporates waste and energy) as a theme of common interest to contribute to sustainable development in the Western Balkans. S.Develop methodologies for implementation of transboundary integrated water management in Lake Prespa and associated river basin as a pilot region, which can then be transferred to other regions. ^Implement a monitoring system to deliver data for development and verification of ecological quali
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Relativistic and Dynamic effects in Computational NMR Spectroscopy of transition-metal complexes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The current proposal aims to established a computational protocol for the rational calculation of NMR parameters in transition-metal complexes by accurately taking into consideration relativistic effects and conformational dynamics. Despite the advances attained in theoretical chemistry methods, the calculation of NMR parameters is not always an easy task. The accuracy with which the shift constants can be obtained depends on several factors and a protocol for these calculations is not always well established and understood. This applies particularly to systems containing heavy element(s) or molecules of open-shell nature. To successfully determine the NMR parameters, the proposed protocol involves the use of all-electron two- and four-component relativistic quantum methods and ab-initio molecular dynamic simulations for the inclusion of the relativistic and solvent effects, respectively. The transition-metal complexes chosen for this project are of high importance in biomedicine, biotechnology, and industrial processes. As the target complexes need to be tested experimentally, this project is multidisciplinary and involves major international collaborations. This project would have a great positive impact on the applicant’s early stage researcher career, identifying her as one of the key players in the opening of a new pathway into computational NMR spectroscopy for systems involving transition-metals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of climate change variability in water availability and water management practices in western mediterranean.' under Fifth Framework.

assistant: **Concept**

The main objective of the CLIMED project is to provide information on the foreseeable climatic changes in the Western Mediterranean. through a multiple approach which includes field hydrological databases, together with statistical models and physically based models, performing an evaluation on how fresh water resources will vary. The project address esevapotranspiration of different land uses, by measuring catchments runoff at small catchments, and performs up scaling through statistical methods directed to the analysis of extreme events, through the use of LISEM model. CLIMED has unimportant socio-economic dimension, which relates the socio-economic data with the information provided by the climate and hydrological stages, in order to produce, for the selected river catchments, an assessment of the impacts of changes on water availability. Another Clime's major goal is to build a conceptual model based on integrated management methodologies, defining guidelines to support decision-making processes and strategic paining for water resources, as wellas defining policy recommendations based on combined top-down and bottom-up approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'WILA19-91, WOMEN’S INTELLECTUAL AND ARTISTIC LABOR 1919-1991' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

WILA19-91 main aim is to to bridge the gap between intellectual history and labor history, and through this methodological innovation not only highlight the disparity between intellectual labor and intellectual achievements, but also challenge historiography's perception of the latter. While intellectual history predominantly focuses on artistic and intellectual achievements, it often fails to question the underlying conditions that made such achievements possible. Consequently, many marginalized groups have been excluded from the canon, as they did not have the necessary working conditions to consistently produce intellectual or artistic labor. The WILA19-91 project focuses specifically on women's intellectual labor from 1919 to 1991, utilizing Yugoslavia as a transnational laboratory space to observe the dynamics of intellectual and artistic labor across different time periods, generations, social classes, nationalities, and ethnicities. The project's outcomes will contribute to establishing new norms for reevaluating artistic and intellectual achievements, ultimately broadening and decolonizing the canon. The project examines work conditions, considering the power structures associated with intellectual authorities, social prejudices, intimate beliefs, and invisible social agreements at various times. To achieve this, it explores the intersection of intellectual, labor, and gender history. By drawing on a diverse range of sources in different languages (Slovene, Croatian, Serbian, German) and amplifying the voices of women from ethnic and sexual minorities, this project will investigate working conditions, attitudes towards work, legislative changes, family dynamics, public reception, financial compensation and care work, in order to understand the division between i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global dynamics of topoisomerase-induced DNA breaks' (TOPOmics).

assistant: **Concept**

DNA topoisomerases are conserved nuclear enzymes that regulate DNA topology by transiently cleaving and resealing the DNA molecule, fulfilling a fundamental role in virtually every aspect of chromosome metabolism. Nevertheless, erroneous or abortive topoisomerase activity can result in persistent DNA strand breaks with the enzyme covalently attached to 3’ or 5’ DNA ends by a phosphotyrosyl bond, an anomalous structure that can compromise cell survival and/or genome integrity with the consequent implications in tumourigenesis. This peculiarity of topoisomerase catalysis also underlies the anticancer efficacy of topoisomerase poisons, which inhibit the re-ligation step of the reaction inducing the formation of DNA breaks that preferentially target highly proliferating and/or repair defective tumour cells. In addition to this link with cancer therapy, defects in the repair of topoisomerase-induced DNA damage have been linked to neurological disease. Understanding the cellular response to topoisomerase-induced breaks is therefore key for important aspects of human health, with possible implications in the development of novel diagnostic, prognostic and therapeutic tools.This project aims at acquiring a comprehensive picture of the dynamics of topoisomerase-induced DNA breaks: from their occurrence and repair to the consequences for genome expression and integrity. We rely on the development of completely novel assays to detect and isolate the different intermediates of topoisomerase-induced break repair, and which overcome major traditional limitations in the field. These tools are subsequently used to integrate the time-dependent and genome-wide distribution of the different steps and final outcomes of the process of topoisomerase-induced DNA break repair. Furthermore, we