RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Financial Decision Making under Multi-Dimentional Uncertainty'.

assistant: **Innovation**

During the recent decade it has become commonly agreeable that existing financial models cannot explain many observable phenomena in the financial world (e.g. the recent mortgage crisis and its worldwide effects, equity premium puzzle and home bias in investing). One flaw of the existing models is that they do not capture the entire picture of uncertainty. This research generalizes models of asset pricing to accommodate additional tier of uncertainty, called ambiguity. Namely, we model financial decision making in a more realistic manner by dropping the standard and restrictive assumption that economic agents know the precise odds of possible events and their accurate monetary outcomes. We formulate financial decision making under multi-dimensional uncertainty using the novel mathematical framework of phantom probability, introduced by Izhakian and Izhakian (2009). This proposal addresses a series of fundamental questions about the nature of ambiguity: How optimal portfolio composition is affected by ambiguity? Whether ambiguity leads to greater savings compared to the standard risk formulations. When do ambiguity and risk reinforce (counteract) each other? How can the level of ambiguity be measured? Can ambiguity be eliminated or reduced by diversification in a manner similar to idiosyncratic risk in the CAPM framework? The effect of ambiguity in an intertemporal framework is highly related to implication of the term structure of interest rate and option pricing. Accommodating ambiguity to option and term structure models can explain some deviations from Black-Scholes pricing formula (e.g. the option “smile”, under pricing and risk-free rate puzzle) and might also produce more realistic term structure model. This research project is supervised by Prof. Thomas Sargent,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NONHUMAN ADENOVIRUS VECTORS FOR GENE TRANSFER TO THE BRAIN' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Formidable challenges remain to prevent and treat successfully neurodegenerative diseases. Traditional pharmacological approaches, as well as those using stem cells, have made progress but their impact remain limited. As suggested by clinical results in Canavan and Parkinson’s disease, gene transfer offers substantial potential. However, this strategy of therapeutic intervention also brings unique obstacles - in particular the need to address feasibility, efficacy and safety. BrainCAV&apos;s foundation is the potential of canine adenovirus type 2 (CAV-2) vectors, which preferentially transduce neurons and undergo a very efficient long-distance targeting via axonal transport. Moreover, the episomal long-term expression leads to safe, efficient neuron-specific gene delivery. We proposed a structured translational approach that spans basic research through pre-clinical model feasibility, efficacy and safety. To provide a proof-of-principle of the effectiveness of CAV-2, we tackle mucopolysaccharidosis type VII, a global, orphan disease commonly affecting children, and Parkinson&apos;s disease, a focal degeneration of dopaminergic neurones commonly affecting aged population. To develop and execute this project, BrainCAV brings together an interdisciplinary combination of partners with unique expertise that will take CAV-2 vectors to the doorstep of clinical trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Characterization of the architecture, composition and evolution of a novel light perception organelle in an emerging model fungus.'.

assistant: **Objectives**

Light perception is one of the most important sources of information for life on Earth. Its importance is such, that several microbial eukaryotic lineages independently evolved analogous sub-cellular ‘eye-structures’ to achieve a similar function. In the microbial lineages we see a similar ‘recipe’ for these systems; a light occluding or refractory surface positioned next to an action potential-generating opsin rich membrane layer. These systems represent one of the most spectacular cases of multiple convergent evolution of a cellular system.Recently, one such eye-organelle structures was described in the early-diverging zoosporic fungi Blastocladiella emersonii (Be). This putative organelle relies on a unique fusion protein (CyclOp), of a rhodopsin domain and a guanylyl cyclase domain to perceive light. Due to the capability of the CyclOp protein to control the intracellular cGMP levels of the cell, it has been intensely studied as an optogenetic tool for signalling-dependent studies. These results highlight the importance of discovery science in non-standard model microbes. However, we still do not know which cellular and molecular elements compose the wider CyclOps-system and how they interact with each other. What is more, the evolutionary history and origin of the organellar protein network remains unknown. The FungEye project aims to characterize the cellular structure, proteome and evolutionary ancestry of this novel light perception organelle. For this we will reconstruct the complete 3D cell architecture of Be zoospores to understand this cellular structure and characterize the wider protein network of the CyclOps-system. Once characterized, we will be able to reconstruct the CyclOps-organelle evolutionary history through its proteome by phylogenomics. Such pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Vascular Inflammation early discoverieS through Transformative computational Approaches' (VISTA).

assistant: **Innovation**

Vascular inflammation (VI) drives most cardiovascular diseases, the leading cause of global mortality and disability, with atherosclerosis as a key manifestation. Current clinical strategies focus on advanced stages of atherosclerosis, where interventions yield limited benefits. VISTA aims to transform this paradigm by pioneering computational tools for early diagnosis and treatment, bridging the gap between preclinical research and clinical translation. VISTA integrates computational mechanics, chemo-mechano-biology, and machine learning to tackle the challenges of multifactorial diseases. By introducing groundbreaking in silico tools, it seeks to reshape our understanding of VI, advancing preventive and personalized cardiovascular medicine.Key challenges in VI include: (1) Current approaches struggle to synthetise the wealth of evidence on the interplay between biomechanics, biology, and systemic processes. (2) Translating causal insights into clinical applications requires linking evidence to precise mechanisms. (3) Clinical approaches and preclinical research remain rooted in traditional theories, lacking support from in silico tools that fail to incorporate real-world perspectives.VISTA tackles these challenges through three objectives: (1) Developing a graph-informed modelling approach to create virtual patient models by synthesizing evidence-based networks of multiscale interactions. (2) Uncovering mechanistic pathways of VI by creating workflows that combine physics-based models, surrogate modelling, and generative AI. (3) Demonstrating the credibility of in silico methods in clinics and biomedical research.This roadmap will deliver an innovative framework for the early discovery of multifactorial VI mechanisms, uniquely integrating tissue biomechanics, systemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Investigating the Molecular Mechanism of Human Centrosome Assembly'.

assistant: **Objectives**

The centrosome has long been known to promote accurate chromosome and cell division through the regulated nucleation of microtubules. Defects in centrosome function are thought to lead to chromosomal instability, an important factor in the initiation and progression of cancer. The goal of the research proposed here is to investigate the molecular mechanism of centrosome assembly and pericentriolar material (PCM) recruitment in human cells. Studies will focus on the human homolog of the C. elegans centrosome component SPD-2, which has been established in the host lab to play a key role in these processes. I will identify additional components of the PCM and its regulation through biochemical analysis of interacting proteins and genome-wide RNAi screens in human tissue culture cells.The aims below employ proteomic, cell biological, and genomic approaches, including novel techniques for the study of protein function in human cells. Aim 1: To perform a structure-function analysis of the role of human SPD-2 in centrosome function. Aim 2: To identify hSPD-2-interacting proteins using biochemical isolation. Aim 3: To identify genes required for hSPD-2 localization and centrosome function using high-throughput RNAi screens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'in flight Trajectory optimizAtion through advanCed simulation TechnICs'.

assistant: **Innovation**

The Commercial and Airline Pilots are skilled to deal with their aircraft emergencies. On the contrary, when the occurrence of unusual situations, requires trajectory change during IFR navigation, pilot in command, involved in a short time analysis and synthesis, could be not able to consider all those aspects affecting the new flight trajectory negotiation.In such situations the pilot may have great advantages in using additional capability providing supports and increased awareness in answering to trajectory change requests.  A  Decision Support System (DSS) can be introduced to allow the pilot to have in every instant the awareness of alternative paths, suggested by the tool, that can decrease trip time, fuel consumption and consequently chemical emissions and noise.TACTIC project will contribute to analyse and solve the problem of characterizing the pilot’s behaviour in decision making when unforeseen events force to a change in the reference trajectory with or without the help of an on-board Decision Support System.The main objective of TACTIC will be to evaluate such a Decision Support System. The quantification of the advantages of such an interactive tool will be the main output of the project. Eventual suggestions for enhancements of the tool as well as new interaction modalities or uses will also be provided.To reach this objective, a simulation environment that replicates present and future ATC and airborne system configurations will be set up. This test bed environment will be used to perform a set of simulations to study:• the impact of different pilot behaviours in the decision making process when unforeseen events force a change on the reference trajectory;• the impact of the Decision Support System on pilot workload and situation awareness and aircraft/a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'PEptides Promoting Tolerogenic Interactions with Microbiota' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Food allergy (FA) is a growing health issue in urbanized countries, notably affecting children, with prevalence rates of 5.7% to 16.6% in Europe due to egg and cow's milk allergies. Western lifestyle factors and environmental exposures contribute to FA by causing inflammation and damaging epithelial barriers. Dysbiosis, an imbalance in gut microbiota, impairs immune development and tolerance, leading to an exaggerated Th2 response and reduced RORγt+ regulatory T cells (iTregs).Current FA treatments are limited, highlighting the need for new approaches. Bioactive peptides from enzymatically hydrolyzed allergens offer a promising alternative to traditional oral immunotherapy (OIT), potentially reducing allergenicity and side effects. These peptides may induce tolerance more effectively and positively influence gut microbiota.The PEPTIM project aims to explore the mechanisms of oral tolerance with bioactive peptides by analyzing immune responses and microbiota changes. Using murine models and in vitro cultures, the study will investigate the impact of these peptides on gut microbiota and intestinal function. Objectives include: (1) Comparing immune and microbiota changes with intact versus bioactive peptides during OIT, (2) Developing models to study microbial roles in tolerance, and (3) Examining interactions between bioactive peptides, microbial communities, and gut epithelial barrier. This research seeks to enhance understanding of FA mechanisms and explore new therapeutic strategies.


**Keywords:** Peptides,  Food Allergy, Microbiota, Tolerance, Metabolites, Gut, Homeostasis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modified Gravity: from Compact Objects to Dark Energy' (MGCODE).

assistant: **Innovation**

The origin of the accelerated expansion of the Universe remains elusive. The so-called Dark Energy might be a manifestation of modified gravity at very large scales. While near-future observatories will improve the current bounds on such a possibility, they will not likely be conclusive as to its nature. An opportunity arises from the study of modifications of gravity at shorter scales, specifically around compact objects like black holes and neutron stars, recently made possible through gravitational-wave observations.This project aims to dramatically improve the constraints on cosmological modifications of gravity by means of an interdisciplinary approach involving tools from High Energy Physics, and both astrophysical gravitational-wave and cosmological observations. Modified gravity dynamics at different scales can be described in a model-independent way as Effective Field Theories according to symmetry principles. Strong constraints will come from a combined theoretical and phenomenological study within this framework. Both analytical and numerical tools will be developed and employed to qualitatively and quantitatively compute the expected signatures on gravitational-wave astrophysics, allowing to hold these models against observations. The constraints will then be translated to the cosmological modifications of gravity, drawing novel conclusions as to which theories can consistently explain Dark Energy while satisfying bounds across a large range of scales.Ultimately, this project will foster the collaboration among the High Energy Physics, Cosmology and Gravitational-Wave Astrophysics communities, enabling a much faster and efficient progress in the field of modified gravity in general. This includes a more focused use of the available computational resources fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Assessing the potential for renewable energy in cities' in the context of a Fourth Framework call.

assistant: **Objectives**

The central purpose of this proposal is to characterise the micro-climate within cities in relation to urban form. The specific aims are: 1 To establish quantified generalised relationships between microclimatic characteristics at a neighbourhood scale and the geometric morphological properties of urban form. 2 To develop a simplified urban porosity model that describes the microclimatic characteristics of an urban texture, in overall terms, so that as the physical form of the urban texture is changed, the likely effect on environmental conditions, energy use and the potential for renewable energy can be determined. 3 As a first step towards validation, to apply the model and the environmental assessment techniques involved to a selection of representative existing European urban textures for which data can be obtained 4 To apply the model and associated techniques to two particular case study urban sites where major interventions are planned so that alternative proposals can be assessed in collaboration with the municipalities concerned, in this way testing the potential of the model as a practical bioclimatic urban design aid. 5 Based on the experience of these practical applications , to assist municipalities, such as those involved in 4, in drawing up urban design guidelines and in considering the implications for byelaws, legislation, etc. The principal beneficiaries of the project will be planners, architects and other professionals involved in urban issues, for whom the urban porosity model will be a major advance as a bioclimatic urban design aid, applicable to any urban area throughout the European Community. Municipalities and local communities will thereby benefit by having an objective means of assessing the environmental impact of alternative proposals for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interworking of Nomadic Multi-domain Services' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The universality of the IP protocol will continue to be a driving force of the global IT economy, but mobile wireless access is regarded as the technology of choice for allowing users to access all the potential applications and location dependent services anywhere anytime, with special requirements regarding ease of use, confidentiality, and cultural diversity in the European market.The overall scope of the INTERNODE proposal is to investigate, enhance and demonstrate on a real network, technologies for the efficient provisioning and service level interworking of IP VPN services for nomadic users across multi-domain and heterogeneous networks. INTERNODE will address multi-domain heterogeneous (Wireless LAN, GPRS/UMTS and Next Generation IP based networks with mobility features) inter-working and security standards supporting access to Internet and Intranet services.Objectives:INTERNODE will design, specify and implement a Service Provisioning Support (SPS) platform, which will be used to create multi-domain services for nomadic users (E-business, nomadic Internet and intranet access, personalised services, customer self care, etc.).Other objectives are set up a technology experiment to integrate IP, mobile services and digital certificate technology at transport and application levels. Also to integrate the technology components and test in an operational network, to develop intelligent service profiling support, to provide a truly secure Internet banking application and to contribute to relevant standard organisations and IST dissemination mechanisms.Work description:The work scope is to design and develop a novel, open, highly efficient and scaleable Service Provision Support platform, that will be built using multi-domain and heterogeneous telecommunications network