RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Multimedia support network for fashion and style'.

assistant: **Innovation**

MULTIFAST aims to develop a business organisation based on the provision of services, strictly related with the production of multimedia application for Fashion and Style, with particular regard to the electronic publishing and electronic commerce, personalised multimedia services, brokerage of advanced multimedia products/services. Through the provision of services, MULTIFAST intends to become a co-producer of the titles, owning rights over their economic results.The major objectives of MULTIFAST are: - To provide services to the multimedia industry and to the users of multimedia applications operating in the fashion sector. - To become profitable and achieve break-even-point after two years period through the production and sale of three types of services/products. - To start a business organisation whose final reference structure will be a European Economic Interest Group, constituted by the partners of the project that will carry out: a brokerage service for the commercialisation of multimedia products/services the direct production and commercialisation of original content multimedia products. - To improve the competitiveness of European multimedia industry by monitoring Innovations in multimedia technologies, improving the quality of products, enlarging the content with European wealth in Fashion sector. The main results of MULTIFAST will be: - technological, management, marketing support: MULTIFAST will be devoted to supporting and fostering the multimedia European industry in organising a service environment relevant to the editorial, manufacturing and commercial needs of this industry. There exists, in fact, a strong need to improve the competitiveness of European multimedia industry, enhance the technological level of the production, improve the quality of its
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Critical developments in research with primates: laboratory and field studies - The European Federation for Primatology in 2000' in the context of a Fifth Framework call.

assistant: **Objectives**

The scientific and technological aims of the meeting are to advance knowledge in the biology and evolution of the primates, and to consider the applications of that information in specific contexts of animal welfare and impending European legislation (Directive 86/609/EEC), in addition to issues in biomedical research and conservation. Fourteen eminent scientists will contribute major discussions in field and laboratory research.The main themes are: Evolution and Biology, including Genetics, Reproduction and Mating Systems, Ecology and Conservation and Cognition and Conflict, including aspects of captive care. The meeting will encourage interchange between scientists from Eastern and Western Europe, and facilitate communications between universities, governmental institutions, and private laboratories involved in biomedical research.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-2000-00420-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Role of apoe in the pathogenesis of alzheimer's disease and in atherosclerosis'.

assistant: **Objectives**

- To define common and newly designed apoE isoforms and domains involved in the interaction with its ligands. - To produce these apoE isoforms in large quantities. - To identify and characterize the interaction of these apoE isoforms with known and novel protein ligands in vitro and in vivo. - To generate transgenic mice carrying genes that code for these apoE isoforms and amyloid precursor protein. - To characterize these mice with respect to the development of atherosclerosis and Alzheimer's Disease.By using interdisciplinary approaches, this project aims to study systematically how alterations in the structure of apoE affect its functions which lead to human disease. Special emphasis will be placed on the role of apoE in the pathogenesis of atherosclerosis and Alzheimer's Disease. Alteration in apoE which changes its interactions with lipoprotein receptors, the secreted proteins such as amyloid peptide b (Ab) or intracellular proteins (such as tau and other protein ligands) in the brain may lead to atherosclerosis and Alzheimer's Disease, respectively. Our knowledge on domains of apoE which are required for the binding of apoE to these receptors and other proteins are largely unknown. Understanding the molecular mechanisms and pathophysiology of diseases caused by apoE mutations may provide effective intervention for the prevention of coronary heart diseases (CHD). In addition, variations at the apoE gene locus affects the risk for Alzheimer's disease (AD), the most common cause of dementia. Presently, no effective treatment for AD is known. Such treatment may become possible if we understand the molecular interactions between apoE and its intracellular or secreted protein ligands present in the brain. The major emphasis of this project will be placed on how the abno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Beam self-cleaning beyond its current understanding' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The goal of BESCLING is to shed light on the physics of the beam self-cleaning (BSC) effect. This is driven by Kerr nonlinearity and consists of the spontaneous increase of the spatial quality of a multimode beam, which turns from speckles in the linear regime to a bell shape at sufficiently high power. Since its first observation, BSC has attracted great interest, mostly because it allows for improving the performances of state-of-the-art optical fibre technologies; remarkable examples are the power scale-up of fibre lasers and the resolution enhancement of multiphoton imaging devices. Despite these successes, the physical mechanisms behind BSC are still largely debated. Specifically, recent experiments demonstrated that for achieving BSC the temporal beam evolution plays a pivotal role. Whereas the temporal dimension has been often ignored in the investigation of BSC.Here, I propose a new approach to dig into the physics of BSC. I will build up a holographic mode decomposition tool, which, in addition to retrieving the mode occupation at the fibre output, allows for obtaining information on the beam temporal profile. This will pave the way to a fully spatiotemporal interpretation of BSC, e.g., it will enable the understanding of the simultaneous occurrence of BSC and supercontinuum generation, whose physical interpretation has been largely disregarded, so far. In addition, to survey the generality of BSC, I will explore photonics platforms beyond standard multimode optical fibres like few-mode optical fibres and lossy fibres made of soft glass or polymer. To date, theoretical models do not apply to these types of systems and, from the experimental point of view, only a few observations of BSC have been reported.To this goal, the Laboratoire Interdisciplinaire Carnot d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Accretion disks, Jets, and High Energy Phenomena in Astrophysics' (1998-2002).

assistant: **Innovation**

The aim of the school is to bring an up-to-date formation in the theory and the observational facts concerning accretion and its related phenomena, jet production and high-energy emission in astrophysical objects. We aim also in providing practical training for the use of new generation instruments suited for the study of such phenomena. Accretion process is thought to play a major role in many places in the Universe: the star formation must take place through the collapse of molecular clouds towards a core, the final stage being the formation accretion disk feeding the young star; Active Galactic Nuclei are very probably due to accretion onto a super massive black hole in the centre of galaxies; cataclysmic variables and X -ray binaries are also the result of accretion of a companion star onto a stellar mass compact object, either a white dwarf, a neutron star or a stellar black hole. Gamma-ray bursts are also believed to be produced by the release of enormous amount of energy during a violent accretion process, being probably the final stage leading to a black hole through either the coalescence of two compact objects or the final collapse of a very massive star.The formation of jets seems to be ubiquitous in all these phenomena, and are associated in some cases with very high energy emission. Despite very different physical conditions, it seems that the basic picture based on magneto-hydrodynamics could account for all these phenomena, but the details are still the subject of intensive research. In 2002 or in the very next years, new instruments with unprecedented sensitivities, energy and angular resolution will be ready to provide new information about all these objects in various wavelength domains: radio (ALMA) and optical (VLTI) interferometers, X-ray (CHANDRA,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European travelling exhibition initiative' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This unique initiative will utilise the skills of twenty major European institutions to enable a European tour of two biotechnology exhibitions, now being developed in Germany and the United Kingdom. The German exhibition will tour to Greece and Portugal, while the UK exhibition will tour to France and Portugal. Each exhibition will tour for one year, reaching approximately 1.5 million visitors.  These complementary exhibitions aim to inform the non-specialist public about contemporary practice in biotechnology, especially genetics. The UK exhibition looks at the science behind genetically modified food, the German exhibition looks at the basic principles of genetics and the methods of genetic engineering. Both exhibitions look at contemporary issues in these fields and discuss what the future might hold. All the texts and interactive displays in the exhibitions will be translated into the language of the countries to be visited.  Each of the twenty European partners will contribute to the project by giving advice and assistance from their own specialist areas. The partners have a wide range of expertise in biotechnology, exhibition development and touring exhibitions. Not only will this venture play a key role in the advancement of the European public's understanding of biotechnology, it will also help to develop the skills and expertise of all our partners. Through this European collaboration, we shall develop a wealth of experience and knowledge which will be invaluable in developing the touring biotechnology exhibitions of the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Automated computer-based lay planning and interface to leather cutting for footwear SMEs' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

An expert system approach is suggested to apply computer technology to a traditional and critical area of shoemaking - that of cutting leather for shoe components. This is a complex area traditionally requiring a high degree of skill and using materials that can account for 40% of the cost of a shoe. The proposal introduces pre-planning to cutting components from a skin of leather, assessment of the resulting lay plan and linking this to the cutting stage. It is based on automatically laying out and interlocking complex pattern pieces for good material utilisation. Account has to be taken of the irregularities of shape and characteristics of leather skins and the requirements of individual components to be cut (production, quality and directional constraints). Interfaces will be developed for inputting this information after assessing appropriate, commercially available, input devices (digitisers, scanners etc.). It is aimed at delivering benefits to shoemakers in terms of cost reduction, improved productivity, consistency, work appeal and improved opportunities for quick response and expanding the application of modern technology. Man/machine interfaces will be improved with a flexible mixture of high technology and enhanced human skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ANDALUSIAN RESEARCHERS´NIGHT 2012' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

As part of the Innovation policy of Andalusian Region, Fundación Descubre (www.fundaciondescubre.es) with the University of Almeria,  University of Cordoba, University of Granada, University of Huelva, University of Malaga, Pablo de Olavide University, University of Seville, Jaen University and National Research Council (CSIC), the Association of Promoters and Producers of Renewable Energy and the Economy, Innovation and Science Regional Goverment have decided to participate on the Researchers´Night 2012 call.ANDARES is a proposal based on the objective to enhance public recognition of Andalusian researchers and their work based in one unique activity, which involves eight Universities and Research Centers in our region.Discover Foundation aims to participate in this call like one of the pillars of his public performances in 2012 with the aim of:1. Bringing science and research to the general public, our activity pretend show the reseachers´ problems and feelings in their life and we will try to explain by our proposal how is important the research activity for the society nowadays and for the global economic situation2.  Promote the scientific studies among young people3. Invite social groups particularly interested in the topic of research projects involve on the activity (Alzheimer, renewable energy, environmental movement, business associations related to renewable energy …)With this activity, the researchers could show their work to people with high interest in the areas of knowledge presented in the different micro-talks presented on the event (patients, employers in the sector of renewable energies)such as Project presentations made by participants, whose will allow us to move Andalusian society with greater clarity and force the value of investment in disseminat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Creative processes for enterprise innovation' (CREATE), addressing dissemination and exploitation.

assistant: **Impact**

The project will deal with the capacity of the enterprises to be creative. Successful organisations create competitive advantage through innovation and creativity, which is the first step of innovation process. Such companies can not be creative and innovative by accident; they must effectively manage the innovation process. Thus, the general project goal is to increase the awareness and the capacity of the European enterprises about methodologies and techniques that may promote the creative climate inside the enterprise and, thus, the innovation both through the generation of new ideas and even the optimal utilisation of resident" know-how and technology that often are unexploited or not valorised. According to this goal, we have already studied and benchmarked about 16 methodologies and 80 techniques developed both by scholars and consultants at international level: through this preliminary analysis, we have identified and defined the "best of breed" in terms of methodologies and techniques. Two industrial groups will be the field tests for the selected approach: the two chosen sectors (home appliances and motorcycles) are significantly characterised by the continuous need for innovating and gaining competitive advantage through technological development. Some more theoretical sessions will take place with two other industrial users. These awareness sessions aim to spread the general concepts about creativity and to improve the knowledge about the creative process. Moreover, the project aims to spread the main concepts towards other industrial fields that could highly benefit by the adoption of such techniques. Dissemination of information will be highly promoted throughout its duration. We have planned to deliver, in particular, 7 seminars, 3 in Italy, 2 in Norway an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Clinical Proof of concept for a RNA-targeting Oligonucleotide for a Cystic fibrosis-F508del MEDication' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cystic fibrosis (CF) is a progressive life-shortening disease caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene leading to a dysfunctional CFTR protein. The disease affects over 70,000 patients worldwide and while many mutations are known, the F508del mutation affects 90% of all patients. The absence of CFTR in the plasma membrane leads to a dramatic decrease in chloride efflux, resulting in viscous mucus that causes severe symptoms in vital organs like the lungs and intestines.  For CF patients that suffer from the life threatening F508del mutation only palliative treatment exist.PRO-CF-MED addresses the specific challenge of this call by introducing the first disease modifying medication for the treatment of the CF patients with F508del mutation. The PRO-CF-MED project has been designed to assess the potential clinical efficacy of QR-010, an innovative disease modifying oligonucleotide-based treatment for F508del patients. Partners within PRO-CF-MED have generated very promising preclinical evidence for QR-010 which allows for further clinical assessment of QR-010 in clinical trials. PRO-CF-MED will enable the fast translation of QR-010 towards clinical practice and market authorisation. PRO-CF-MED has the potential to transform this life-threatening condition into a manageable one.


**Keywords:** Cystic fibrosis, oligonucleotide, disease- modifying medication, First in Humans clinical trial, F508del mutation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Elucidating mechanisms of dopaminergic neuronal degeneration using C. elegans and high-throughput genetic approaches' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

BACKGROUND:Parkinson’s Disease, characterized by the progressive degeneration of dopaminergic neurons, afflicts millions of people. Yet, no effective therapeutic strategies are available.This work uses Caenorhabditis elegans to study dopaminergic degeneration. C. elegans is a small nematode, highly amenable to genetics and high-throughput approaches, with a simple nervous system that is highly conserved at the level of gene expression and pathology with humans. This study also utilizes a mutant in a Transient Receptor Potential (TRP) channel, trp-4(d), in which dopaminergic neurons properly specify but later on progressively degenerate.OBJECTIVES:1. Understand the molecular mechanisms of dopaminergic neurodegeneration2. Identify potential therapeutic targets3. Uncover novel causes of neuronal cell deathSTRATEGIES:1. Using a candidate approach I will investigate which of the known cell death pathways (apoptosis, autophagy, necrosis) mediate trp-4(d) dopaminergic degeneration.2: I will perform a suppressor screen on trp-4(d) mutants to identify genes that can stop dopaminergic cell death. High-throughput genetic approaches (automated screening and Whole Genome Sequencing) will be employed for mutant isolation and identification. Characterization of the retrieved genes will elucidate molecular mechanisms that can block dopaminergic degeneration.3. It is conceivable that more genes exist that when mutated have, like trp-4(d), detrimental effect to the survival of DA neurons. I will take an unbiased high-throughput forward genetic screening approach designed to selectively isolate dopaminergic degeneration mutants to reveal novel causes of neuronal cell death.RELEVANCE:The expected outcomes are of high medical significance and relevance to human neurodegenerative conditions.