RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Diffuse-Optical Monitor of Cerebral Hemodynamics after rtPA Administration in Acute Ischemic Stroke' to be submitted under Seventh Framework.

assistant: **Abstract**

Ischemic stroke is the leading cause of morbidity and long term disability in Europe and United States and one of the leading causes of death. The intravenous recombinant tissue-type plasminogen activator (rtPA) is the premier drug indicated for treatment of acute ischemic stroke. Current guidelines call for its administration within the first ~three hours of the stroke onset (now being extended to 4.5 hours due to positive results of ECASS III study). However, despite its success, about 50% of patients treated with \rtpa suffer morbidity and even death. It is during this initial emergency treatment phase that a multitude of monitors are deployed in order to monitor the reperfusion (or lack thereof) of the ischemic parenchyma before widespread necrosis takes place. In this multidisciplinary project, I bring together biomedical physicists and clinical neurologists to develop a novel diffuse optical technology to continuously, non-invasively and at the bed-side monitor microvascular, local, cerebral blood oxygenation, cerebral blood volume and cerebral blood flow. Proposed technological developments will enable the use of this technology in a challenging environment such as that of the emergency care of acute ischemic stroke. We will monitor hemodynamics in penumbral regions before, during and after rtPA administration. A particular issue of interest would be the onset of recanalization and its sustainment. This pilot data will be used to assess the value of these monitors to follow the effects of recanalization (or lack thereof) on local microvascular metabolism. If successful, it may provide clinicians with the ability to individualize rtPA treatment and also to develop secondary interventions to improve the treatment outcome. This, in turn, should reduce socio-economic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Symbolic Computation and Automated Reasoning for Program Analysis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Individuals, industries, and nations are depending on software and systems using software. Automated approaches are needed to eliminate tedious aspects of software development, helping software developers in dealing with the increasing software complexity. Automatic program analysis aims to discover program properties preventing programmers from introducing errors while making changes and can drastically cut the time needed for program development.This project addresses the challenge of automating program analysis, by developing rigorous mathematical techniques analyzing the logically complex parts of software. We will carry out novel research in computer theorem proving and symbolic computation, and integrate program analysis techniques with new approaches to program assertion synthesis and reasoning with both theories and quantifiers. The common theme of the project is a creative development of automated reasoning techniques based on our recently introduced symbol elimination method. Symbol elimination makes the project challenging, risky and interdisciplinary, bridging together computer science, mathematics, and logic.Symbol elimination will enhance program analysis, in particular by generating polynomial and quantified first-order program properties that cannot be derived by other methods. As many program properties can best be expressed using quantified formulas with arithmetic, our project will make a significant step in analyzing large systems. Since program analysis requires reasoning in the combination of first-order logic and theories, we will design efficient algorithms for automated reasoning with both theories and quantifiers. Our results will be supported by the development of world-leading tools supporting symbol elimination in program analysis.Our projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Current European and Cross-National Comparative Research and Research Actions on Migration' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Migration and the characteristics which constitute its parameters, dynamics and complexities comprises one of the most paramount matters in contemporary Europe. Under these designated circumstances, the necessity of relevant, concise, and useful knowledge are prerequisites for the design of efficient and constructive policies. Although particular databases such as EUROSTAT and OECD offer valuable insights into these migratory dynamics, a comprehensive, efficient and integrative database which synthesizes, categorizes and maps out the vast analytical accounts on migration throughout Europe is non-existent. This project, bringing together 16 leading research institutions, networks and policy institutes throughout Europe, aims to proficiently fulfill this gap crucial for policy-purposes through the construction of a central migration hub. This hub will be of instrumental value due to its capability to operate as a key grammar in the design of current and future policy. Essentially, it accumulates and consolidates past, present and future migration research through providing an extensive yet succinct overview of migration drivers, infrastructures, flows, and policies, allowing for an improved systematic understanding of the factors that constitute the interaction between these analytical categories. The accessibility, accumulation and integration of research in one hub will be an integral element for improved policy making as it concentrates and visualizes relevant data – thereby facilitating information acquisition in pursuance of policy oriented goals. As of such, a continuous research-policy dialogue is prevalent throughout the construction of the hub, an insight which enables its users to visualize and develop migration scenarios- entailing a classification system for m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'food SAFEty assessment of «GREEN» disposable food PACKaging' (SAFE-GREENPACK).

assistant: **Innovation**

There are two clear trends in the food industry: the demand for convenience foods and the push for increased packaging sustainability.While take-out meals require disposable food contact materials (FCM) the packaging industry is experimenting with sustainable alternative-to-plastic solutions.But are these materials as safe as their replacement?Although these FCM must comply with the framework Regulation (EC) No 1935/2004, there is no specific regulation at the European level that is as comprehensive as the Commission Regulation (EU) No 10/2011 for plastic. As a result, the chemical composition and the health risks of these disposable FCM applications remain largely unknown.Further investigations need to be conducted. Preliminary targeted studies detected fluorinated substances in alternative single-use tableware and fast-food packaging. These (and others) substances can then find their way into the environment or human body. A 2019 Spanish investigation detected endocrine disruptors in the body of every participant studied.However, disposable FCM’s contribution to the population's exposure to harmful chemicals is still unclear, and a risk assessment is necessary. The 24-month SAFE-GREENPACK project aims to contribute to filling this gap. With a growing fast-food market, Spain will serve as a proof of concept for evaluating the food safety of alternatives to disposable plastics.First, this FCM market will be mapped by a comprehensive market study. Next, analytical data on contaminants will be provided. Those will result from an optimised workflow based on untargeted screening, prioritisation of the results and quantification of relevant substances. High-level secondments will contribute to the quality of the results. Finally, a risk assessment will highlight priorities f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ADVANCED COMPUTATIONAL STUDIES OF  DYNAMIC PHENOMENA IN MAGNETIC NANO-MATERIALS' in the context of a Seventh Framework call.

assistant: **Objectives**

The opportunity to modify the excitation spectra in materials with modulated properties has stimulated striving research activity in the area of artificial nanostructures with novel functionalities - so called metamaterials. Magnetic materials with modulated properties also possess properties that cannot be reduced to those of their constituents. The best example is the phenomenon of giant magneto-resistance (GMR), the discovery of which was marked by the Nobel Prize in Physics last year. Similar to photons in photonic crystals, the spectrum of magnons (spin waves) in periodic magnetic nano-materials shows a tailored band structure. The latter consists of bands of allowed magnon states and band gaps in which there are no allowed magnon states. By analogy to studies of other band-gap materials, the field of research is called magnonics. Further development and application of magnetic nano-structures requires a thorough understanding of the relation between their physical and chemical structure and useful magnetic functionalities. The ability to accurately predict properties of fabricated magnetic nano-structures and complete devices theoretically would generate huge savings of resources, but remains illusive at present. The goal of this project is to consolidate efforts of European and Indian researchers with a broad range of leading expertise to create, to validate and to implement a flexible computational framework for modelling of dynamics in realistic magnetic nano-materials and complete devices. The framework will be validated via comparison of computational results against those obtained experimentally or using analytical theories. We will model magnetic dynamics in topologically complex nanostructures, in view of applying them in design of realistic devices. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Prevention and Remediation of Insulin Multimorbidity in Europe' (PRIME) under Horizon 2020.

assistant: **Objectives**

PRIME introduces the novel concept of insulin signalling as a key mechanism underlying the multimorbidity of major mental and somatic illnesses. It is well known that aberrant insulin signalling causes high health and socioeconomic burden through its role in diabetes, metabolic syndrome, and obesity. We posit that the impact of ‘insulinopathies’ is still largely underestimated, since insulin multimorbidity also extends to the brain, where altered insulin signalling appears to be implicated in dementias such as Alzheimer disease and – based on our pilot work - in mental illnesses characterized by compulsivity, especially obsessive compulsive disorder and autism. We therefore further posit that insulin multimorbidity evolves throughout life, necessitating a lifespan approach. PRIME brings together a multidisciplinary team to (1) extend our understanding of insulin multimorbidity across the lifespan, (2) understand the causal mechanisms linking somatic and mental insulin-related illnesses, (3) develop tools for early diagnosis, improved clinical care, and prevention of insulin-related lifespan multimorbidity. We will leverage the world’s largest registry, clinical cohort, and population data sets to identify and validate new insulinopathies. Through an interdisciplinary battery of innovative approaches, we will clarify the causal mechanisms linking peripheral and central insulin signalling to body-brain comorbidity, integrating across animal models and studies in humans from molecule to cell, brain, cognition, and behaviour. Our prior evidence enables PRIME to bring the new knowledge to society, based on e.g. repurposing medication and lifestyle interventions (diet/exercise monitored by mHealth assessment), identifying and validating novel drug targets, developing and test
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'From the understanding of KRAS-RAF membrane dynamics to new therapeutic strategies in cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Cellular homeostasis is controlled by the RAS-MAPK pathway. This pathway is dysregulated in human diseases, especially cancer, in which more than 50% of cases carry aberrations that hyperactivate RAS-MAPK signaling. In this context, KRAS mutations are the most frequent oncogenic drivers. Therapeutic suppression of pathogenic KRAS-RAF-MAPK signaling to achieve disease control in cancer patients still represents a challenging target.  KRAS dimers and multimers at the membrane (collectively referred, together with adaptors and effectors, as to “KRAS signalosome”) influence the activation of KRAS signaling. I provided the first biological evidence that dimerization is required for the function of oncogenic KRAS (Ambrogio et al, Cell, 2018). Indeed, one fascinating and still largely unexplored aspect of KRAS biology is the functional impact of KRAS complexes at the membrane for signaling and drug sensitivity. No inhibitors of oncogenic KRAS clustering have been identified so far. Interestingly, wild-type KRAS antagonizes oncogenic KRAS, resulting in reduced oncogenic signaling. The overarching goal of this proposal is the characterization in vitro and in vivo of the “KRAS signalosome” in terms of functional dynamics and related actionable vulnerabilities. My strong background in KRAS biology provides me with the expertise to propose an ambitious, yet feasible plan to understand the tumor suppressor effect of wild-type KRAS protomers in mutant KRAS-driven complexes by identifying and validating membrane interactors differentially recruited by wild-type and mutant KRAS (Work package 1). In parallel, I will study the relevance of RAF kinases localization at the membrane as key feature to sustain oncogenic MAPK activity in vivo (Work package 2). Finally, I will screen new compou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative Infusion Airframe Manufacturing System' (IIAMS) targeting Horizon 2020.

assistant: **Abstract**

IThe IIAMS project is related to the advanced low-weight and high-performance structures domain. More specifically, it is included inside the ITD Airframe development area and it involves the manufacturing and assembling of a new concept of a composite wing box structure that will be tested on the turboprop aircraft prototype of the programme.The main objective is develop an innovative pilot system able to manufacture an integrated R/H and L/H composite wing box structure according with JTI-CS2-2017-CFP07-AIR-02-53 topic specifications. This pilot system will be based on Out of Autoclave resin infusion technology, and its ultimate purpose is to demonstrate that an alternative technology (to prepreg + autoclave) with lower costs, reduced lead times and lesser environmental footprint can achieve similar design tolerances and quality levels. The result of this development will also allow portability.Mtorres will optimise its AFP technology to manufacture with the maximum productivity the spar and stringers to simplify the movement of the hot forming station.They propose to use a light table design to enable the human collaboration with robots as well as to facilitate the direct taping of dry fibres on the mould.Mtorres will use multi-function connections and optimise the ancillaries to simplify the subsequent infusion and curing processes.The infusion process will be simulated using specific software and CFD to avoid dry spots, increase the speed, minimise waste materials, decrease the exothermal risk and viscosity development. Then, experimental trials will be carried out using a precise control of the temperature and measuring the resin and hardener flows. It will be validated the use of self-heated mould and blankets but also ""onsite"" air ovens that can be placed on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Do Pathogen Extracellular Vesicles Deliver Crop Disease?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Filamentous plant pathogens (fungi and oomycetes) cause the most devastating crop diseases and thus significantly threaten global food security. Essential components of their virulence arsenal are proteins called cytoplasmic effectors that are delivered inside plant cells to suppress immunity. One of the major scientific challenges in this field is understanding how effectors are secreted and translocated into host cells; a question that is hotly debated. An exciting breakthrough in my laboratory revealed that cytoplasmic effectors accumulate in extracellular vesicles (EVs), implicating this as a delivery route. This critical discovery establishes a vital need to address:• What proteins reside in EVs and how do EVs traffic them between pathogen and host cells?• How are EVs formed and how are effectors packaged into them?• What are the routes for uptake of cytoplasmic effectors into host cells and how do they reach their destination?Each question will be answered by a corresponding workpackage (WP) that brings challenging, innovative approaches to the study of molecular plant pathology. In WP1 proteomics and transgenic approaches will allow the EV proteome to be determined and high-throughput automated electron microscopy will resolve the 3-dimensional organisation of the interface between plant and pathogen. In WP2, new molecular cell biological approaches and genome editing will facilitate an understanding of effector secretory routes and EV biogenesis. In WP3, fusion or endocytosis of EVs with plant cells will be studied and the endocytic routes to delivery of effectors to their final destination will be defined.PathEVome will develop a ground-breaking understanding of effector delivery from filamentous pathogens to the inside of living plant cells. It will provide to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Putting the top down on AMPK protein complex' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The 5' adenosine monophosphate-activated protein kinase (AMPK) is a master regulator of cell energy metabolism.  AMPK (dys)regulation has been connected to metabolomic disease, conditions of the heart and viral infections. AMPK is fine-tuned through its structural features, which are dependent on mRNA isoform splicing, protein complexation, post-translational modification (PTM), and allosteric activation . AMPK’s diverse regulatory role is deeply connected to its post-translational modifications (43 known phosphorylation and 36 known other PTM sites). The result of this structural diversity is an extremely large combinatorial space of (1) unique covalently modified α-β-γ isoforms, the proteoforms, and (2) their unique non-covalent assemblies, the complex species. However, the structural diversity of AMPK is not well understood. The goal of this project is to to study the modifications and endogenous diversity of AMPK proteoforms and complex species from a ""bird's eye view"", depicting and mapping in parallel existing complete length AMPK forms, using denatured and native Top-down Mass Spectrometry (TDMS). -Outgoing phase, Ying Ge Lab, University of Wisconsin-Madison (UWM) (M1-24): Recombinant AMPK complex to study coded proteoforms (O1-2) and establish a strategy for purification of endogenous AMPK (O3). -Incoming phase (M25-36), Charlotte Uetrecht Lab, University of Lübeck (UzL): Transfer learned technologies and map endogenous AMPK proteoforms in different tissues (O4). Design endogenous-ike AMPK proteoforms (O2). -Non-academic phase (M37-42) Bruker Daltonics GmbH (BRUKER): Close gaps in data acquisition and get more out of AMPK with next-gen MS instruments (O2).The aspired methodology and results will be important for the identification of AMPK biomarkers and, ultim