RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Towards Perfect Chemical Reactors:Engineering the Enhanced Control of Reaction Pathways at Molecular Level via Fundamental Concepts of Process Intensification' to be submitted under Seventh Framework.

assistant: **Abstract**

Molecular-level control of chemical reactions presents undoubtedly the most important scientific challenge on the way to fully sustainable processes. Factors responsible for the effectiveness of a reaction include number/frequency of molecular collisions, orientation of molecules at the moment of collisions and their energy. Current reactors offer a very limited control of the above factors. Reactions usually take place in random geometries and the energy is brought to molecules by conductive heating which is non-selective and thermodynamically inefficient.A groundbreaking solution here can only be achieved by creating a “perfect” reaction environment, in which the geometry of molecular collisions is fully controlled while energy is transferred selectively from the source to the required molecules in the required form, in the required amount, at the required moment, and at the required position. The current proposal aims at the first of its kind development of structured reactors using electric and electromagnetic fields for alignment, orientation and selective activation of targeted molecules. To engineer such “perfect” reaction environment the fundamental concepts of Process Intensification are applied. We build here on the Nobel Prize-awarded fundamental works in the area of the reaction dynamics and molecular reaction control that were not considered in chemical engineering thus far. Chemistries studied are mono- and bi-molecular reactions using CO2, CH4 and H2O, which are of paramount importance for clean fuel production and carbon dioxide management.The proposal bridges chemical physics and chemical engineering incorporating the knowledge domains of chemistry, catalysis, materials science, electronics, computer modelling and micromechanical engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An Advanced Methodology for the Inspection and Quantification of Damage on Aerospace Composites and Metals using an Innovative Approach'.

assistant: **Objectives**

There is an innovative need for more efficient and reliable damage inspection, reducing time and cost of aircraft infrastructures, as well as maintenance-especially C and D Checks- without compromising the safety of passengers and goods transported. The CompInnova project is focused upon the development of an innovative inspection methodology, with automated and manual capabilities, for any type of composite and metallic aircraft structures. The novel structural integrity approach is comprised by three parts: a qualified Phased Array (PA) and Infrared Thermography (IRT) method attached to a mobile Vortex robot, a Damage Tolerance (DT) structural integrity assessment technique processed on a computer and an innovative repair system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Climate Action To Advance HeaLthY Societies in Europe' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Despite clear signs that the impacts of climate change are escalating, the global response has been inadequate. Traditional scientific efforts have fallen short of providing knowledge and tools that have been broadly applied in decision-making, and innovative approaches to knowledge translation are needed. To catalyse climate action in Europe to protect public health, our overarching goal is to provide new knowledge, data, and tools on: i) the relationships between changes in environmental hazards caused by climate change, ecosystems, and human health; ii) the health co-benefits of climate action; iii) the role of health evidence in decision making; and iv) the societal implications of climate change for health systems. This will be achieved through five specific objectives: 1) to develop an integrated indicator framework and repository to track the status of health-relevant outcomes of climate actions; 2) to quantify the health co-benefits and full social and environmental costs and benefits resulting from mitigation measures outside of the health sector; 3) to develop innovative surveillance and forecasting tools that facilitate effective response to environmental health hazards (e.g. heat stress, allergenic pollen) caused by climate change and the design, monitoring and evaluation of interventions to mitigate climate change; 4) to investigate how stakeholders engage with evidence regarding the health impacts of climate change, and to develop strategies and tools to facilitate engagement; and 5) to provide evidence and training on the most effective strategies for climate change adaptation and mitigation for health systems, with specific focus on vulnerable populations including those occupationally exposed to hazards induced by climate change. CATALYSE is a powerful,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Isolde' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Principal characteristics of the facility and of the support offered to users: The On-Line Isotope Mass Separator ISOLDE is a factory for short lived exotic isotopes available in ion beams with excellent purity and often highest intensity. In special cases isomeric and other specific ions can be provided. Radioactive nuclides are produced in reactions of 1 GeV protons in thick high-temperature targets. More, than 600 isotopes with half-lives down to milliseconds of more than 60 elements have been produced at highest intensities. ISOLDE has two independent isotope separators feeding the same beamline system. A new laser ion source provides ion beams of extreme purity. The large variety of available species allows not only the systematic study of atomic and nuclear properties and exotic decays far from the line of stability, but also research in related fields like astrophysics and weak-interaction physics. The possibility of pure radioactive implants opens access to the investigation of problems in solid state physics. Bio-medical studies using radioactive isotopes for diagnosis and therapy have introduced life-science into the research programme. The installation of a post-accelerator (REX ISOLDE) will open fields of research with radioactive ion beams of higher energies in 1999. Equipment provided to the users includes electronics, computing equipment, laser installations, chemistry and radioactive laboratories, office space, and user workshops. Experimental installations for nuclear spectroscopy or solid state physics are available. New users will receive full support from the ISOLDE groups and research staff, and will be trained in all aspects of operating the separators. Quantity of access being offered and number of users who may benefit: The facility offers up to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of Butyrophilin-like molecule 1 in intestinal epithelial cell-T cell interactions and immune surveillance' (BUTIES), addressing dissemination and exploitation.

assistant: **Impact**

The butyrophilin-like (Btnl) molecules share similarities with the B7 family of costimulatory molecules for T cells, yet no functions are known. They are encoded in the major-histocompatibility complex (MHC) locus, a region of the genome known to be highly relevant in many diseases. Recently, Professor Hayday's lab identified a novel immunoglobulin-related molecule, Skint1, which appears to be a selection determinant for skin gamma delta T cells. Furthermore, in the absence of Skint1 and normal skin gamma delta T cells, mice develop spontaneous skin inflammation and are susceptible to skin carcinomas. Hence, Skint1 seems to underpin key aspects of skin immune surveillance. Interestingly, Skint1 shares close sequence homology with Btnl1, 4 and 6; moreover, whereas Skint1 is expressed specifically in thymus and skin epithelia, Btnl1, 4 and 6 are expressed specifically by intestinal epithelia. The gut is a site of chronic immune stimulation where the control of tissue inflammation and stress responses is very important. Therefore, the functional relatedness of Skint1 and the Btnl family provoked our hypothesis that Btnl1 and its relatives may be novel regulators of immunosurveillance, by interacting with intraepithelial lymphocytes (IEL) in the gut. Indeed, human Btnl2 is genetically associated with sarcoidosis and ulcerative colitis. To investigate Btnl1, I will use novel anti-Btnl1 antibodies, a Btnl1-Fc fusion protein and Btnl1 knockout mice to define situations in which Btnl1 receptor engagement occurs and the significance of this interaction. I will also attempt to identify the Btnl1 receptor on IEL. Finally, I wish to address the role of Btnl1 in immune surveillance, by examining the interaction of IEL and Btnl1+ cells in a mouse model of epithelial stress. By this,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PATHWAYS TO INCLUSIVE LABOUR MARKETS' to be submitted under Horizon 2020.

assistant: **Abstract**

PILLARS offers a three-pillars framework that includes:  (1) A comprehensive and empirically solid account of the combined effect of (i) past waves of automation technologies, (ii) recent trends of international fragmentation of production in Global Value Chains (GVCs) and (iii) industrial transformation of European regions on EU labour markets, in terms of employment reconfiguration, skill mismatch and migration. (2) A comprehensive set of forecasting scenarios based on the impact assessment in (1) and projection of (i) industries’ future exposure to emerging automation technologies; (ii) EU regional industrial transformation and (de)specialisation; and (iii) functional reallocation of workers along GVC and migration flows; and (iv) potential skill mismatch resulting from projections of skill demand and supply. (3) A systematic evaluation of current labour market policies, based on smart specialisation, and training policies that allows identifying areas of success and directions to be mitigated. This will lead to proposing a coherent and cohesive policy roadmap that includes a battery of action in different policy areas (innovation, trade, education and training) to achieve Pathways to Inclusive Labour Markets. PILLARS’ ambition to contribute to assess current labour market policies and co-design a new generation of policies for the future of work will be fulfilled by a consortium of top scholars, including partners from Latin America and China; an enthusiastic, international, multidisciplinary stakeholder support to the potential of PILLARS; and a top notch academic advisory board.


**Keywords:** Inclusive Policies,  Economics of Innovation,  Globalisation & Global Value Chains,  Industrial Dynamics,  Skills,  Labour Demand & Supply,  Inequality,  Migration,  Region
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SERS-based Technology for EarLy Liquid biopsy Analysis and Recognition' in the context of a Horizon Europe call.

assistant: **Objectives**

STELLAR introduces a groundbreaking approach to early cancer detection, leveraging surface-enhanced Raman spectroscopy (SERS) and artificial intelligence (AI) to analyse microRNAs (miRNAs) in liquid biopsies. This innovative technology aims to revolutionize cancer screening by offering a non-invasive, cost-effective, and highly accurate method for identifying cancer-specific miRNA biomarkers. STELLAR's core innovation lies in its ability to detect and discriminate between normal and mutated miRNAs with exceptional accuracy, even at the level of single nucleotide polymorphisms, without the need for expensive and complex sequencing technologies. The project encompasses the development of a comprehensive system, including a novel miRNA isolation and enrichment method, a SERS-based detection platform utilizing silver nanoparticle-enhanced substrates, and an AI algorithm for data analysis. This integrated approach promises to overcome current limitations in miRNA-based cancer diagnostics, such as high costs, lengthy processing times, and the need for specialized equipment and personnel. STELLAR aims to progress from TRL 2/3 to TRL 4/5, validating the technology with clinical samples and establishing a clear path toward commercialization. The project's multifaceted strategy includes rigorous technical development, IP protection, regulatory planning, and market analysis. The project's success could significantly impact early cancer detection rates, improving patient outcomes and reducing healthcare costs. STELLAR's approach to combining SERS technology with AI-driven analysis opens new avenues for personalized medicine and could set new standards for AI-integrated medical devices. As the project progresses, it will explore various commercialization pathways, including the pote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Revolutionizing Insect Control', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

EFSA recently prohibited 75% of insecticides to account for their toxicity and ecotoxicity. Moreover, the spread of insecticide resistance and invasion of Europe by new tropical vectors and pests require the development of alternative biological techniques.Recently, we hypothesized that shifting the vision of the sterile male from a sexual competitor only to a specific transporter of active biocides to the targeted female might boost the impact of the sterile insect technique (SIT). Here we want to demonstrate this concept using three biocides: Pyriproxifen, Bacillus thuringiensis and a Densovirus against the Tiger mosquito (Aedes albopictus). Pyriproxifen will also be tested against tsetse and fruit flies.We will test the technology both in the laboratory and at an operational scale and model the relative impacts of SIT and boosted-SIT on the dynamics of the targeted population.  Moreover, we will compare the evolutionary response of the target population to these different control pressures (multiple lethal mutations, multiple lethal mutations + biocides), for three different biocides and three demographic strategies.  This will generate breakthrough knowledge on the transmission of biocides and pathogens in insects and the sustainability of genetic control, provide a new control technique for mosquitoes, and improve the cost-effectiveness of SIT in tsetse and fruit flies.We will have to address technical issues associated to mass rearing, sterilization, sex separation and aerial release of mosquitoes as well as regulatory issues required for releasing sterile males coated with bioicides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Balancing social equity and biodiversity outcomes in protected area management.'.

assistant: **Innovation**

We are in the midst of the earth’s sixth mass extinction and the search for effective conservation solutions has never been more pressing. In recent years the model for nature conservation has changed, deeply embedding safe-guarding livelihoods and maximising equity within the missions of most conservation organisations. Re-focusing conservation in this way is based on the assumption that more socially equitable conservation will be both more acceptable to stakeholders, thereby reducing the likelihood of conflict with conservationists, and ultimately more effective in protecting biodiversity. That is the key hypothesis which will be tested in this fellowship.To achieve this I will address three key research objectives: 1) To devise a metric of equity in protected area governance and assess under which conditions protected area governance can be considered most equitable; 2) To explore how variation in equity in protected area governance influences acceptability of the protected area; and 3) To uncover how variation in equity in protected area governance relates with good biodiversity outcomes. I will meet these objectives through: 1) the development of an index of equity based on up-to-date theory and using protected area management plans; 2) a review of conflicts around protected areas and how these relate to equity in the governance of protected areas; and 3) large-scale spatial analyses of protected area effectiveness and forest change in relation to equity. While working in leading European research groups and gaining excellent training in interdisciplinary theory and up-to-date analytical methods, I will: (1) improve knowledge of outcomes of protected area management using recently available data sets; (2) provide conservationists with guidance for the design of pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Circuit mechanisms  underlying sensory-evoked navigation' to be submitted under Horizon 2020.

assistant: **Abstract**

Life-threatening cues such as the scent of smoke or the taste of rotten food cause avoidance behavior in animals. In such situations, instantaneous integration of relevant sensory inputs by motor centers that guide navigation can be a matter of life and death. How is this sensorimotor integration achieved? In vertebrates, it is known that motor command centers in the brainstem receive direct inputs from higher brain areas and cutaneous sensory pathways and in turn control the spinal circuits that drive locomotion. It is less well understood whether these brainstem command neurons are simple integrators relaying information, or whether they add a layer of integration to select locomotor action sequences. Because brainstem neurons are difficult to visualize and access in mammals, it has been challenging to measure their activity in moving animals as they respond to sensory cues. In contrast, larval zebrafish is a simpler vertebrate model in which optical technologies can be leveraged to visualise, record, and manipulate any and/or all brainstem neurons during locomotion. This project will decode the neuronal computations of descending command neurons that integrate sensory inputs and elicit locomotor actions in freely-moving zebrafish larvae. To this end, my group has designed an unbiased method for segmenting locomotor action sequences from noisy behavioral data. Applied to robust assays where larvae navigate in chemical gradients, we are now in a unique position to link locomotor action sequences to the sensory landscape fish perceive. This original approach, together with innovative technologies pioneered in my lab, will reveal brainstem neuronal connectivity and roles in the selection of locomotor sequences. The EXPLORATOME project will lead to models of circuit compu