RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Macroscopic Quantum Superpositions of Light Generated by Quantum Cloning for Applications in Quantum Technologies' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Quantum technologies offer new quality with respect to classical ones by enhancing sensitivity of measurements and offering unconditional security of information transfer. Their optical implementation within the current technology is limited by inefficient detection and use of single photons. The solution is to apply macroscopically populated quantum states of light (MQSL) created by quantum cloning. However, they suffer from low distinguishability. The aim of this project is to merge unique properties of these hybrid states with innovative filtering and detection methods for applications in quantum technologies. The new concept is to use a filter relying on a conditional weak measurement described by a positive operator valued measure. It preserves quantum coherences and entanglement. Also new detection techniques genuine to continuous variables will be tested. Existing sources of MQSL will be improved by quantum state engineering, broadening palette of the experimentally accessible non-Gaussian states. Genuine macroscopic entanglement and multi-mode Bell tests, possibly with preselection technique, will be demonstrated. Feasible entanglement witnesses and measures will be proposed. They will help testing MQSL for quantum information, cryptography, metrology, teleportation and entanglement distillation protocols. Coupling between MQSL and polaritonic Bose-Einstein condensate, also a macroscopic superposition of light, and biomolecules will be examined towards quantum memories. Decoherence effects will be included in all steps of the analysis. Additionally, conclusions about the fundamental aspects of quantum mechanics are expected: testing it against local hidden variable models and the quantum-to-classical transition. Methodology includes analytical and numerical comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Deciphering the molecular basis of regulatory T cell suppression' under Seventh Framework.

assistant: **Concept**

Regulatory T cells (TREG) comprise a subset of CD4+ T cells that maintain immunological tolerance by suppressing immune activation in a dominant manner. TREG helps shaping the immune responses to autoantigens, alloantigens, tumors, pathogens and allergens, and are thus considered a therapeutical target in a large variety of diseases.  One aspect of TREG biology that remains poorly understood is what molecular program(s) are induced in cells that are being actively suppressed by TREG. The specific aims described below are designed to provide a better understanding of the molecular changes that occur as a result of TREG-mediated suppression and determine if the biochemical pathways altered by TREG-mediated suppression can be exploited for therapeutical purposes.1. Characterize the molecular changes that occur in CD4+ T cells and dendritic cells that are being suppressed by TREG using gene profiling and cell signaling experimental approaches.2. Evaluate the importance and therapeutical potential of genes with an expressionprofile altered by TREG-mediated suppression in animal models of human diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mechanisms controlling the developmental response to Wnt signalling in the fruit fly Drosophila melanogaster' (DEV).

assistant: **Concept**

The signalling molecule encoded by the wingless (wg) gene (the fruit-fly homologue of the mammalian proto-oncogene Wnt-1) elicits distinct responses in different tissues during the development of the fruit fly Drosophila melanogaster. In particular, wg is required for the proliferation of the hinge cells (which will give rise to the structures joining the wing to the trunk of the fly), and its over-expression leads to the over-proliferation of the hinge cells.In this project we aim at:(1) to define the specific cell cycle properties of hinge cells that might be related to this proliferative response, and to study their control by wg;(2) to identify genes that are controlled by wg and which mediate the induction of cell proliferation; and(3) to determine fact ors that condition hinge cells to proliferate upon wg stimulation and how these factors relate to cell cycle control.These results might serve as a basis, first, to understand how Wnt signals regulate proliferation during normal development, second, to throw light on the general phenomenon of developmental specificity of intercellular signalling pathways, and third to understand why tumour induction by mutations in the Wnt signalling pathway is tissue-specific.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'World first self-responsive emergency call system' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

What does it happen when a person collapses unconsciously or behaves conspicuously or luggage or any object is left unattended in an elevator? Either the next passenger will bump into the situation or the people behind surveillance cameras, if existing, may react. As a result, safety is limited, operation costs increased and security risks exist. At VIEW Promotion GmbH we have developed a solution that automatically detects emergencies in the elevator, puts them into context and takes appropriate action. Applications include unconscious persons, abandoned objects, vandalism or violent attacks. VIEW goes beyond industry standards offering automatization and optimization of operation and maintenance and reducing operation costs. VIEW prototype has been tested in real scenario with a 100% success with our image recognition and deep learning algorithm technology. Next steps include product optimization for 100% reliability, price reduction and industrialization. We have been in the industry for years and have already secured clients and great interest from the industry. Our customers are elevator owners, ranging from office buildings, to car parks, public spaces or airports. VIEW solution fits within the current trend of Smart Elevators and targets the Global Elevator Modernization market, with an estimated size to reach €10,562M by 2021, growing at a CAGR of 4.16%. VIEW is exploited through two revenue sources: price per unit and a concurrent O&M service fee. Moreover, the smart screen can be monetized through the sale of the advertising space. We expect a 3 years cumulative revenue of €34.6 million by 2023 and grow our team from 7 to 20 employees.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Transforming CO2 into added-value construction products'.

assistant: **Concept**

The European Green Deal sets ambitious targets to GHG emission reductions for the process industry, that can only partly be reached by the transition to renewable energy. Residual, hard-to-abate CO2 emissions from industrial processes such as steel and cement production will need to be captured, and wherever possible, processed and recycled into new products. The shift towards low carbon processes may disrupt existing industrial symbiosis pathways. If no alternative linkages are developed, this may lead to increasing emissions in downstream sectors. The transitions in steel and energy production lead to dwindling supplies of low carbon resources for cement production such as blast furnace slag and coal fly ash. The core concept of Carbon4Minerals addresses the simultaneous use of CO2 from industrial flue gases with current and future waste streams to unlock a vast stock of resources for innovative low carbon binders and construction materials (80-135% lower CO2-emissions than reference). A total of 8 industrial pilots will be built and operated across the process value chain from CO2 capture to cement production and low carbon construction products. This cross-sectorial innovation has the potential to reduce European CO2 emissions by 46 Mt/y, equal to 10% of the EU process industry emissions, while safeguarding the competitiveness of the European industry. A consortium of technology providers, producers and research partners will develop, test and demonstrate the processes. Technical, environmental and economic feasibility will be validated by an integrated assessment, in combination with the development of a service life test package tailored to these new products. Co-learning modules are developed to support industrial implementation and market introduction.


**Keywo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Secure Quantum Communication and Computation'.

assistant: **Objectives**

Quantum Theory is one of the greatest scientific revolutions of the twentieth century. During the last decades, it has become apparent that the tools provided by quantum mechanics can be used in many fields, such as cryptography, algorithms, game theory, and even biology. This is because quantum systems exhibit an intrinsic randomness that can be exploited in order to significantly boost computational performance, increase security of communications and in general achieve tasks that are impossible with purely classical means. On the other hand, the use of quantum technologies in future telecommunication networks, raises important questions on the security of the currently deployed protocols since quantum adversaries will be able to use quantum effects to break widely-deployed cryptosystems (e.g. RSA).The scientific aim of the proposed research project is to build the essential components for secure quantum communication and computing in realistic environments. It stands at the interface between quantum theory and experiments, focusing on the effect of the experimental environment on the implementation and security of different quantum computational models and protocols.  It is expected to pave the way for large-scale quantum cloud computing, so that users can store and process their data on a network using powerful quantum servers, therefore providing a more effective way for computing and communication. The proposed project is highly innovative and interdisciplinary, and it will play an essential role in my career development, since it will allow me to work closely with researchers from different fields and acquire both key scientific and complementary skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COMPETENCE CENTRE MICROSYSTEMS: Liquid Control and Measurement' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The target of the Liquid Handling Competence Centre (LICOM) is to facilitate the access of industry and users (in particular SMEs) to microfluidics and to implement purpose-designed services, based on advanced scientific knowledge and innovative technology, aimed at successfully accomplishing the incorporation of microfluidics in existing and new products.Objectives:The Competence Centre will offer technical support and design skills organised around products and applications knowledge. Concerning the technical domain LICOM focuses on devices capable to analyse, pump, mix, monitor or control small volumes of liquids. In this domain HSG-IMIT is among the leading institutions in Europe, both in terms of knowledge and manpower.Work description:Various activities are offered in order to fulfil the main task of LICOM: to facilitate a broad take up of Microsystem Technology. Marketing Activities are aimed at raising awareness and providing information for take-up. A brochure will inform business executives about the possibilities and benefits of MST. An internet site (www.microfluidics.de) will enable interactive communication. The data base related to this site will be frequently updated in order to establish a portal site for microfluidics. Technical assistance for the development of new products will be given through consultation on an individual basis answering technical questions and queries concerning the practicability of solutions/technologies. Feasibility studies including literature searches as well as preliminary experiments will be conducted and training will be offered. Individual Innovation Workshops will be carried out. Herewith we support our customers in finding new fields of innovation and application. We will help our industrial partners to find out where t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A novel evolutionary perspective on language: The advantage of arbitrariness and roots of discreteness' to be submitted under Horizon Europe.

assistant: **Abstract**

Language is one of the greatest mysteries in the evolution of humankind. It is a remarkable phenomenon that appears to be distinct from other animal communication system, and yet its evolutionary roots remain far from clear. One interesting feature of human language, that does not seem to exist in other communication systems, is the arbitrary relationship between form and meaning. In recent years, many studies have emphasised cases of non-arbitrariness, such as iconicity, and pointed to its advantages for communication, but the merits of arbitrariness itself are rarely considered. This project takes a novel perspective and aims to demonstrate the potential advantage of arbitrariness, in order to elucidate it as an evolutionary adaptive behavioural trait. The specific proposal is that arbitrariness supports communication under noisy conditions. A combination of cross-linguistic comparison, laboratory psycholinguistic experiments, and computational modelling will illuminate the role of arbitrariness in efficient communication. It will demonstrate how decoupling form and meaning reduces ambiguities, when context is available, and explore the effects of various types of naturally occurring noise. The project aims to further demonstrate the role of another quality of arbitrariness: that is, the induction of a discrete communication system. This has consequences for the emergence of complex linguistic characteristics, such as syntax and compositionality. By integrating ideas from distinct fields, such as the evolution of animal communication, and cross-cultural and cross-linguistic human studies, the project has the potential to set forth a novel theory about key aspects of the evolution of language.


**Keywords:** Language evolution,  Iconicity,  Arbitrariness,  Systematici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Experimental investigation of generating atom entanglement for quantum Information processing' (2002-2006) under Sixth Framework.

assistant: **Objectives**

We plan to investigate the generation and the manipulation of atom entanglement by exploiting the variety of methods for atom optics. In the experiment, we will achieve the detection of freely propagating atoms with certainty on the single-atom level and develop a quantum tweezer to extract a certain number of atoms from a Bose-Einstein condensation (BEC) chip. We start with a BEC chip, from which, we can extract a definite number of atoms at will with a quantum tweezer, which may be generated by a focus beam of red-detuned laser light on the chip.Experimentally, the quantum tweezer is turned on adiabatically inside the BEC chip and moved out of the BEC chip at a certain speed so that a desired number of atoms are extracted. In order to achieve the detection of single atoms in free space, we will exploit the interaction between the probe laser sheet and atoms. Since the interaction time between the exciting laser and the atoms extracted from BEC chip is long enough, the spontaneous emission photon at high rate will be sufficient to discriminate the presence of individual atoms. We will develop a lens construction with high number aperture to collect the photons scattered from a probe laser sheet. In this way, it will enable us to detect and determine the exact number of up to a few atoms with certainty. After having successfully extracted and detected single atoms, we will extract two atoms out of BEC chip and switch off the quantum tweezer non-adiabatically.The two atoms will decay along some pairs of correlated direction due to the momentum conservation and atom collision. Specially, we will exploit the variety of methods for atom optics to guide and split each atom only along two specific pairs of directions such that the two atoms will be efficiently entangled in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Bioengineered exosomes based approaches for the effective treatment of non-small cell lung cancer'.

assistant: **Concept**

ABSTRACT: Lung cancer is the principal cause of cancer-related death around the world and has become more predominant among former than current smokers. Smoking, alcoholism, air pollution, occupational exposure are among the main causes of non-small cell lung cancer (NSCLCs). It is difficult to simultaneously deliver therapeutics and nucleic acid to the target site. With the advancement of nanotechnology, a delivery system composing of cellular proteins which can bypass the reticuloendothelial system (RES) and have the ability to release payload at the specific target site is the necessity of the current era. Exosomes (Exo) are clinically acceptable, having protein membrane composition and the ability to deliver payload at specific target sites. Having endogenous origin, Exo evade immune recognition and clearance compared to exogenous nanovesicles. Exo are natural carriers of nucleic acids and they can be engineered to deliver siRNA as well as anti-cancer drugs. In this we propose the conjugation or covering of mesenchymal stromal cells (MSCs) derived exosomes with HSP4 peptide (target specific to NSCLCs) and loading them with Gefitinib (GEF), an EGFR inhibitor and SPC24 siRNA (target for NSCLCs and metastasis). The delivery of GEF and SPC24 siRNA using bioengineered exosomes (BESG) will reduce their dosage; improve patient compliance and life expectancy of patients. BESG will be evaluated for their uptake mechanisms and their mechanism of action in cell culture models of NSCLCs. BESG will specifically target the NSCLCs and release its payloads at cancer site. The underlying mechanisms, pharmacokinetics, biodistribution and anti-cancer activity will be evaluated in xenograft model of NSCLCs using advance imaging technologies. The BESG developed during this program will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Single-Molecule Studies on Condensin'.

assistant: **Concept**

For division of each of our cells, 2 meters of DNA should be replicated, compacted into a few-micrometer size chromosomes that are segregated and distributed via mitosis, so that each daughter cell gets exactly one copy. How this large DNA genome is well organized into such a small volume is one of the hottest issues for the understanding of chromosomes. Condensin, a ring-like structure formed by SMC dimers, kleisin, and two heat domains, embraces DNA and condenses the DNA using ATP hydrolysis. However, the molecular mechanism on how conformational changes of condensin compact DNA is still unknown. Here, the applicant Dr. Je-Kyung Ryu proposes to use two orthogonal single-molecule approaches, “high-speed AFM (HS AFM)” and “single-molecule fluorescent magnetic tweezers” to reveal the molecular mechanism of condensin. HS AFM imaging is a unique technique to record video-rate real-time images for entire structure of a protein in physiological condition with high spatiotemporal resolution (~1nm, ~50ms). In addition, using single-molecule fluorescence microscopy combined with magnetic tweezers, the applicant can understand how the cooperative binding of condensin to DNA correlate with DNA condensation. These two approaches will not only provide most important clues to understand the mechanism of condensin how DNA enters and exits the condensin ring and how condensin shapes chromosome but also include technical advances in single-molecule techniques. This work will be carried out in the laboratory of Prof. Cees Dekker, who is a world leader in HS AFM and single-molecule biophysics of DNA-protein interactions. The applicant’s experts in single-molecule biophysics, fluorescence microscopy, and biochemistry will make synergetic effects with the resources of the Dekker lab to col