RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Experimental and Numerical insight into Scale effects in granUlaR slides in the mountainous Environment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

As a result of climate change, growing population and development, mountainous regions are facing increasing frequency of landslides resulting in destructive impacts on infrastructure, human and natural resources. Thus, reliable methods for predicting landslides and their runout distances are required. Landslides are often modelled as granular slides. Currently, the runout distance of such granular slides cannot be reliably predicted from laboratory-based studies due to so-called scale effects (i.e. differences in slide characteristics when the size/scale is reduced in the laboratory compared to the event in nature). This results in a dangerous underprediction of the runout distance or requires expensive large-scale or numerical investigations. A talented female researcher is addressing this challenge in this ENSURE project in collaboration with an internationally recognised pioneer researcher in this research topic. The primary goal of ENSURE is to provide a full physical understanding and quantification of scale effects in granular slides through economically efficient laboratory experiments and numerical simulations. A secondary goal is to develop a reliable upscaling method accounting for scale effects in granular slides that links laboratory-scale properties with field-scale events to ensure the predictive capability of laboratory experiments. ENSURE is an integrated implementation platform of an “innovation-justification-application from lab-to-field” approach to elucidate the critical phenomenon of granular slides by fully understanding the physical reasons for scale effects for the first time, which is essential for landslide hazard assessment. Further, the researcher will undergo a training-through-research program, a special career development agenda is design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced structural dynamic experimental facilities' (ASDEF).

assistant: **Concept**

TXT=AB The ASDEF (Advanced Structural Dynamic Experimental Facilities) group of European Laboratories provide a unique combination of facilities for advanced structural, seismic and dynamic experimentation and analysis. Alone in the world ASDEF's facilities provide for multiple complementary techniques for the assessment of dynamic behaviour of large scale models and full size structures in diverse fields which include civil, structural, process, geotechnical and offshore engineering. The participating large-scale laboratories are: - LBTF, CARDINGTON Large Building Test Facility, which is part of the UK'S Building Research Establishment (BRE). - ELSA, the large reaction-wall facility of the Joint Research Centre of the European Commission at Ispra in Italy. - TAMARIS, the large shaking table and dynamic testing laboratory of Commissariat a l'Energie Atomique (CEA) at Saclay in France. - ISMES, the Structural and Dynamic Testing Laboratory at Bergamo in Italy. ASDEF will provide young researchers from across the EU with access to the full range of large scale dynamic facilities including electromechanical and electrohydraulic shakers, impact facilities, shaking tables and reaction wall pseudo-dynamic testing. The TAMARIS shaking table enables large scale models to undergo seismic tests. In addition to the training of the users for defining and conducting such tests, they will be able to improve the knowledge on seismic behaviour of buildings. Some specific aspects will be analysed by these tests: dynamic effect, boundary conditions at the base of the structure and eccentricity in the building.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Monitoring of cell signaling pathways via interaction of fluorescently tagged proteins' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

At present, fundamental questions in biomedical translational research require the use of non invasive nanometer resolution techniques that facilitate the study of cell structure and function in vivo. The proposed project is highly interdisciplinary: it encompasses advanced research techniques in biophysics, cell physiology, and molecular biology. The long term aim of the project is to establish a cutting-edge multidisciplinary program in biomedical and translational research at the Department of Biophysics at the P.J. Šafárik University in Košice, Slovakia. The foundation of this program is laid out within EU structural fund projects CEVA I and II and SEPO I and II. The applicant, Dr. Stroffekova has advanced knowledge of cell physiology and biophysics, and was therefore approached to participate in the design and planning of the infrastructure for above mentioned EU projects, and to carry on her further research at the Department of Biophysics. The specific objectives of the present project are to introduce new research methodologies that will be used within infrastructure and to expand the scientific potential at the Department of Biophysics. Specifically, the project will introduce and establish electrophysiological measurements by whole cell patch clamp, site-directed mutagenesis and creation of fluorescent fusion proteins (FFPs) for application in confocal microscopy and fluorescence resonance energy transfer (FRET) measurements, and immunocytochemistry. All these methodologies will be used in novel approach to quantify the onset and modulation of apoptosis by FFPs, which will expand research capabilities for a molecule targeted photodynamic therapy in malignant cells. The proposed project and its funding will greatly improve applicant’s abilities to establish a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Large eddy simulation techniques to simulate and c ontrol by design cyclic variability in otto cycle engines'.

assistant: **Concept**

The objective of LESSCO2 is to give the car industry the ability to predict and thus control by design cyclic variability in internal combustion Otto cycle engines. These phenomena are detrimental to engine efficiency and pollutant emissions. Controlling them by design allows taking full profit of the benefits in terms of CO2, efficiency and pollutants that can be expected from novel concepts like CAI. As today's 3D CFD tools are not able to address these phenomena, LESSCO2 proposes a highly innovative work on the Large Eddy Simulation technique. Novel LES models and numerical techniques will be developed, including work on using realistic auto-ignition chemistry for gasoline and natural gas, tested and transferred to the projects industrial partners. They will validate the obtained industrial LES engine design tools by performing multi-cycle simulations aiming at predicting cyclic variability and estimate their impact on future designs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optochemical control of P2X receptor ion channels: dissecting their role in pain signalling' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Pain has a large socio-economic impact, it is estimated that up to one in five Europeans (19%) suffers from chronic pain, costing the EU around €300 billion per annum. Understanding the molecular and cellular mechanisms underlying pain signalling is critical for the development of novel treatments. P2X receptors are ligand-gated ion channels opened by extracellular ATP. They have well-established roles in chronic pain, particularly in the case of P2X3, P2X4 and P2X7 subunits. However, a lack of sufficiently powerful tools has seriously handicapped our understanding of P2X receptors in these roles. Recent technological advances have now made it possible to engineer ligand-gated ion channels to be selectively controlled by light. This enables non-invasive control of native channel activity with high temporal and spatial resolution. Here it is proposed that a light-activated P2X4 receptor (LiP2X4R) will be engineered and used in vivo to dissect its precise role in pain signalling. In mice expressing LiP2X4R in neurons and microglia, LiP2X4 will be activated and any resultant pain-related behaviours monitored (e.g. mechanical and thermal pain hypersensitivity). This optogenetic approach will address important aspects of pain signalling mechanisms, including: the neuron-glia interactions that underlie pain signalling; and the specific contribution of P2X receptors towards pain signalling in vivo. It will enable the precise role of P2X receptors to be defined in a manner not possible before, and will provide insights to the mechanisms that underlie chronic pain processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Circulating Extracellular vesicles (cEVs): a novel nutrient delivery mechanism and therapeutic target in metabolic pathologies (METEV)'.

assistant: **Concept**

The sensing of blood nutrient availability, storage, and delivery requires robust inter-tissue crosstalk mechanisms which, for the last 70 years, we have still trying to understand in health and disease. When these mechanisms fail, metabolic pathologies such as Metabolic Syndrome (MetSy) ensue. MetSy is a complex entity that has emerged as a worldwide epidemic. The lack of knowledge of its nature, the absence of any efficient treatment, and the increasing prevalence imply a major public health concern. MetSy is defined as abdominal obesity, insulin resistance, misbalance in lipid profile, and high cardiovascular and diabetes type 2 risks. These factors, dysregulated simultaneously, suggest an underlying mechanism linking all these metabolic impairments. In 2019, I published an article proposing a novel nutrient delivery mechanism from blood to tissues based on extracellular vesicles (EVs) biology. Since then, other groups have corroborated our findings, supporting the idea that, as a complementation of the classical nutrient delivery mechanisms, EVs in circulation (cEVs) are able to deliver metabolic fuels from blood to tissues. While this new cEVs-based mechanism is occurring in healthy subjects, we dont know if it is falling in MetSy patients, or even if it is relevant enough to alter human physiopathology. METEV aims to study these last two concepts, to address a better understanding of metabolic pathologies, in particular, the role of cEVs in the development of MetSy. My main personal objective is to learn (training) and take advantage of cutting-edge technologies to improve the knowledge of metabolic pathologies with potential relevant implications in multiple fields of medicine. This will allow forging future interdisciplinary collaborations with professionals fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Alternative Grassroots Organizations as a Response to Austerity: perspectives from Southern Europe' (AGORA) targeting Horizon 2020.

assistant: **Abstract**

In recent years the global financial crisis and the consequent austerity measures have triggered protest movements all over the world. In Southern Europe there has been a strong wave of mobilizations directed to defend public welfare provision. These anti-austerity movements have been characterized by a call for social justice framed in solidarity and inclusion, against the perception of a reduced capacity by the state of addressing citizens’ needs. This low level of trust in institutional politics has triggered the creation of alternative spaces of deliberative and participatory democracy, directed to experiment with different political expressions. A crucial question is whether and how this claim for different forms of democracy has been translated by social movements into organizational forms that bring increased democracy also into the economic sphere. In order to address this still underinvestigated issue, AGORA focuses on those entrepreneurial activities that originate from the civil society, in this specific case as a direct expression of anti-austerity movements, that are characterized by the prevalence of social objectives over profit maximization.AGORA will investigate the organizational dynamics and characteristics of Social and Solidarity Economy (SSE) organizations that emerged in Spain and Portugal in the aftermath of the financial crisis. The general objective of AGORA will be to assess how SSE is politically framed by investigating the linkages between social movements and SSE.Starting from a social movement perspective, AGORA will adopt an interdisciplinary approach, by finding synergies between social movement scholarship, economic anthropology, organization studies and SSE scholarship (which is per se interdisciplinary), with the aim of integrating di
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Preparation and Application of new n-type, Electron Acceptor Materials in Organic Solar Cells' (DAMASCO).

assistant: **Concept**

Organic Photovoltaics have advantages compared to traditional inorganic solar cells, offering the prospect of low fabrication cost and flexiblility. The properties of organic and polymeric materials, open the perspective of a widely distributed photovoltaic low cost mass production. For this development to take place, the devices power conversion efficiency have to reach 10% and their lifetime have to increase. The development of polymer based solar cells has made significant progress but more research in the design and synthesis of new photoactive organic materials is needed.Bulk-heterojunction (BHJ) organic solar cells have active layers composed by electron-donating p-type semiconductors and electron-acceptor n-type materials. DAMASCO project will contribute to the design, synthesis and testing of new electron acceptor molecules and polymers with n-type properties for organic BHJ solar cells.Perylene diimides dyes are a significant class of n-type organic semiconductors for optoelectronics. These materials have good thermal and photochemical stability, high electron affinity, high absorption and their electronic properties can be easily modified via chemical tailoring by introducing substituent groups.  Due to these properties, perylenes are candidates for organic photovoltaics. DAMASCO will develop novel perylene based molecules and polymers with n-type semiconduction properties and good solar harvesting.DAMASCO project has the following objectives: 1) design and synthesis of novel electron acceptor perylene based systems; 2) preparation and characterization of polymeric donor/acceptor  photoactive blends; 3) assembling of BHJ solar cells and photovoltaic performance evaluation.The expected results are: a) new highly stable molecules and polymers with n-type semicon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Coordinated european surface ocean palaeo-estimation collaboration' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

CESOP intends to significantly improve our ability to reconstruct oceanic climate variability beyond the instrumental period (>100 years). It will provide critical data for testing/validating climate models over time scales decisive for climate prediction. State of the art palaeo-observation methods will be improved and CESOP will build upon a unique European world-class network of collaborating laboratories. The partners treat the infrastructure units as an Integrated System of Infrastructures to jointly utilise the specific strengths of each facility. The project will develop highly accurate methods with a major improved accuracy compared with more traditional approaches, utilising the Mg/Ca paleothermotry technique. The technique will be calibrated against modern ocean variables, standardised analytical methods will be developed, the method will be checked against alternate methods, new climatic time series and time slices produced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Insulin receptor-mediated modulation of nociceptor function. Characterisation of primary sensory neurones co-expressing VR1 and insulin receptors' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The majority of nociceptive primary sensory neurons (PSN) express vanillin receptor 1 (VR1). In physiological conditions Varies activated by heat above ~42°C resulting in acute burning sensation. In pathological conditions VR1 is activated by normal body temperature initiating the development of prolonged and chronic burning pain sensation, which often accompanies diseases, such as diabetes mellitus (DM). The reduction in the heat threshold of VR1 is produced by post-transactional modification of VR1. Our recent data suggest that insulin; a key regulator of metabolism could initiate such modification of VR1. Insulin reduces the blood' s glucose concentration and failure of this action results in DM. In one form of DM insulin cannot reduce the blood' s glucose concentration as its signalling system is dysfunctional, which is overcome by higher production of, while at a later stage by high amounts of exogenous, insulin. Based on our pilot data, we hypothesize that high insulin levels might contribute to the development of burning pain associated with some types of DM. In the proposed experiments first, by using combined immunoassaying we will study whether the molecular basis for insulin-induced modification of VR1, the co-expression of the receptor for insulin and VR1 exists on PSN. Than, by recording from in vitro skin-nerve preparations, and acutely isolated and cultured PSN we will elucidate whether or not insulin is able to activate VR1-expressing PSN. Next, we will measure whether insulin can induce transmitter release from PSN in the spinal cord. Finally, we will find out the molecular mechanisms underlying the insulin-induced activation of VR1. To prove that the insulin-induced effects are mediated through VR1 the experiments will be done on mice from which the ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Innovative three dimensional thick film technology for the control of thermal cyclers and micro controlled environments'.

assistant: **Concept**

Thermal cycling machines are used extensively to manipulate the growth rate of biological samples. However, the units, regardless of their application suffer from poor temperature control and poor thermal distribution. This project aims to develop a new thick films technology that can be used in thermal cycling units and other applications to enable individual sample control, thereby significantly increasing accuracy and reliability whilst vastly reducing power costs and material wastage.