RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Sewer Ecologies: The Hidden Heritage of London's Urban Infrastructure' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Thousands of kilometres of tunnels run under the streets of London, keeping waste contained and concealed. London inherited this sewerage system from the Victorians, most notably Chief Engineer Joseph Bazalgette, prompted by the Great Stink of 1858. While it has endured remarkably well, population growth means that tens of millions of tonnes of untreated sewage now overflow into the Thames every year, posing a serious environmental threat. This project moves beyond sewers as purely technical infrastructures to consider the relationship between public attitudes to waste and pollution, and the material dynamics of waste management from the Victorian era to the present daya topic that is particularly relevant considering the growing effects of waste in the Anthropocene. Its main objective is to examine sewers as integral parts of Londons urban heritage, through the interdisciplinary lens of heritage studies, contemporary archaeology, ecocriticism, and urban studies, bringing them together within the scope of the environmental humanities as an ecology of sewers. Such an ecology can shed light on how infrastructures produce heritage legacies that engage humans, nonhumans, and the environment, and have ramifications for what it means to live in the contemporary city. In doing so, a form of urban infrastructural heritage that is concealed yet emergent can be unveiled. This knowledge can further aid cities in solving complex problems relating to global challenges such as clean waterways, climate adaptation, and infrastructure modernisation. Much like climate change itself, ecologies are difficult to envision and need to be actively sought out. A deeper understanding of Londons sewers, from the creation of its sewerage system to the present day, can address the question of what
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Engineering Technology-based Innovation in Medicine' (ETIME) targeting Seventh Framework.

assistant: **Abstract**

Background: Healthcare systems worldwide are increasingly unable to meet growing demand for and cost of healthcare. Changing demographics leading to increasing demand for services of increasing cost exacerbate this problem. Thus,healthcare costs are an increasingly unaffordable share of economically constrained national budgets.More specifically, an average 10% of healthcare costs are for acute and intensive care, which equates ~1% of GDP in many EU countries – a significant share. Highly trained doctors and nurses are the scarce and costly resource in critical and acute care. Thus,improving care and productivity in intensive and acute care units by merging engineering, technology and medicine presents a significant research and economic opportunity and challenge.The Specific Problem: While acute and critical care doctors have a range of technology and sensors at their disposal, their ability to rapidly provide the more consistent, patient-specific care required to improve productivity and patient outcomes is limited. In particular, they are unable to take full advantage of the wealth of data they are presented to best utilise the pumps,ventilators and other technologies used to provide care.The Solution: The application of clinically validated computer models of patient physiology that can be made patient-specific using data at their bedside can integrate this patient data into a clear physiological picture of patient-specific condition and response to treatment, as well as help guide therapy. These computer models can be combined with automation technology to improve both the productivity and quality of care, alleviating demand on scarce and costly personnel.Proposed Answer: Model-based Therapeutics (MBT) is an emerging field combining computer models of human physiol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Zooarchaeology and Mobility in the Western Mediterranean: husbandry production from the Late Bronze Age to Late Antiquity' to be submitted under Horizon 2020.

assistant: **Abstract**

Human survival and success is substantially determined by the ability to move across the landscape and adapt. Consequently, ‘mobility’ is a crucial topic in historical and archaeological research. To overcome the seasonal scarcity of food and the related over-grazing of pastures, it is essential for animal husbandry to move across territories. However, the decision to allow or deny rights of way to mobile people and livestock depends on political judgements. How might these shape animal husbandry production, and society?The period between the Late Bronze Age and Late Antiquity in the Western Mediterranean witnessed the development of complex societies with a high territorial component, the Roman conquest, and the decline of the Western Roman Empire. Animal husbandry reflects human decisions regarding the management of resources, and the study of livestock rearing in specific geographical locations is possible through the isotopic analysis of ancient animal teeth. Consequently, we can analyse whether the nucleation of power occurring during the Bronze and Iron Ages, the centralization in Roman times and the later re-fragmentation in Late Antiquity transformed animal husbandry production. Crucially, we can then understand how political systems and decisions shaped human mobility through investigating animal production.ZooMWest brings together isotopic chemistry, ancient DNA, zooarchaeology and geospatial analysis through four related work packages. Other than elucidating long term debates in archaeology –did transhumance exist in prehistoric Europe?–, this multidisciplinary and innovative project will create an open-access database of strontium and oxygen stable isotopes of the Iberian Peninsula and Italy. This database will enable us to refine geographic provenance to an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TyRec process: Whole Tyre Recycling within 30 Minutes with Molten Zinc – towards a circular economy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Composite Recycling Ltd has developed a unique, patented process to recycle tyres using molten zinc.  Using molten zinc has a number of advantages over traditional processes:Economic process as:Speed of tyre destruction is just 30 minutes rather than 2-4 hours as in traditional rotary kiln processes.  No shredding / granulating; whole tyres, savings in capital and operational costs.  No scale-up issues: doubling the surface area of the molten material doubles the throughput.  Separation: the molten zinc is used to separate the steel and carbon black.  Every year over 1.5 billion tyres are discarded worldwide.  Tyres are a composite plastic material and difficult to recycle, but they do contain value in their constituent raw materials such as oil, carbon black, copper and steel.  Because the process utilises existing, proven technologies from low cost industries such as the hot dip galvanising and the carbon black manufacturing industry the technological and hence commercial risk is minimised.  The tyre recycling process was proven to work as intended in collaboration with University College Cork.  The next step is to construct a demonstration plant and to proof the recycling of the tyres on this scale providing customers with the confidence of investing into full scale plants.  For all the above waste streams the European and US legislators are increasing the pressure on industry to develop a solution, presenting an opportunity.  At the same time a US government report suggests that the US requires up to 200 tyre recycling plants with the European market of similar size as the car ownership is similar.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tandem Repeats Associated with Neurogenomic Somatic Instability and Neurodegeneration' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Dementia and other neurodegenerative diseases are among the leading causes of disability worldwide and have an immense societal impact due to lack of effective treatments. For developing better preventive and therapeutic strategies, it is essential to clarify their still largely elusive genetic basis and pathophysiology. Emerging insights from the study of rare hereditary repeat expansion disorders caused by elongations of repetitive DNA sequences (""tandem repeats"" (TRs)) indicate that TRs could induce instability of neuronal DNA (""neurogenomic somatic instability""), and thereby instigate molecular changes that lead to neuronal degeneration. However, the role of highly prevalent TR variations or their somatic instability in the pathogenesis of common age-associated neurodegenerative diseases is unknown. Here, I aim to assess the role of TRs and their somatic instability in the pathogenesis of neuronal degeneration, the defining hallmark of all neurodegenerative diseases. To this end, I will 1) systematically identify TRs whose size or somatic instability are related to neuronal degeneration in the general population and/or disease severity in repeat expansion disorders, using an innovative approach combining ""liquid biopsy"" of neuronal tissue, high-throughput ultra-deep long-read DNA sequencing and ultrasensitive biomarkers of neuronal degeneration, 2) delineate the neuroanatomical pathways affected by TR somatic instability through comprehensive neuroimaging analyses, and 3) disentangle the underlying molecular and cellular mechanisms, using an extensive integrative multi-omics approach with experimental validation in neuronal cell lines and post-mortem human brain tissue. The wealth of unique insights from TRANSIT-ND could substantially increase our understandin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural determination and development of a sitedirected mutagenesis system for the photosynthetic reaction centre from the purple bacterium rhodopseudomonas acidophila' (1994-1998).

assistant: **Concept**

The objectives of this proposal are to obtain a high resolutlon atomic structure for the photosynthetic reaction centre (RC) from the purple bacterium Rhodopseudomonas acidophila and subsequently to develop a site-directed mutagenesis system. The understanding of structure/function relationships in RCs are hindered by the lack of (1) a third structure for comparative analysis and (2) a stable mutagenesis system for Rhodospeudomonas viridis due to the inability of this species to grow chemoheterotrophically. The work program to meet the objectives aims to exploit the experience accumulated at the host institute concerning membrane protein crystallisation coupled with; the availability of a pre-existing genomic library, chemoheterotrophic growth of Rhodopseudomonas acidophila, and the ability to mobilise cloning vectors into this species. This proposal would also provide me with an unique opportunity to receive specialised training in the field of membrane protein crystallography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European collaborative study on molecular genetics in affective disorders' (1994-1998).

assistant: **Concept**

To study the genetics of Affective Disorders at the molecular level using the candidate gene strategy (mainly association and sib-pair methods) with relevant DNA polymorphic markers.To use molecular genetics to validate diagnostic subclassifications of affective disorders (phenotypic heterogeneity): from genotype to phenotype.To delineate gene-psychosocial environment interactions through different cultural settings across European centers.To consolidate and exploit a large European data bank of genetic, familial, clinical, psychosocial and psychopharmacological data available for Affective Disorders. The understanding of genetic aspects of depression has benefited from recent findings with DNA markers. Affective disorders have been the subject of numerous studies using molecular genetics, covering a significant part of the genome. Most recent work suggests that several chromosomal regions may play a role in the etiology of Bipolar Affective Disorder. These regions of interest include genes on chromosomes 18, 21, 4, 5, 11 and X but have not yet been finally confirmed.  The main objective of this project is to test these hypotheses as well as new promising results in a powerful sample of patients with Bipolar and Unipolar depression recruited for association studies, in the framework of BIOMED1 collaborative project (EC Concerted Action on Affective Disorders: interaction between genetic and psychosocial vulnerability factors - Contract No BMH1-CT-92-1217 (1993-1996) - project leader: Prof. J. Mendlewicz). Genetic markers will be tested in a large European sample of patients and controls, already available for psychiatric genetic studies. This data bank of more than 1300 individuals with DNA available will be exploited in order to reach the main objective. This objective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulation of corticotropin releasing factor - cfr - gene expression in the central nervous system' to be submitted under Fourth Framework.

assistant: **Abstract**

Corticotropic-releasing factor (CRF) is a neuropeptide that displays a variety of effects in the nervous system. CRF is the primary physiological mediator of stress responses and stressinduced disorders in the brain. The effects of acute stress are mediated in part by neurons of the locus coeruleus (LC), a nucleus containing 50% of the brain's norepinephrine neurons. Chronic stress increases the firing rate of LC neurons and increases levels of norepinephrine in this nucleus, indicating that CRF mediates the biochemical adaptive response of LC noradrenergic neurons to chronic stress. CRF induces short- and long-term changes in the physiology of neurons. Long-term effects of CRF requires changes in the expression of genes. It has been recently observed by us that CRF is able to alter gene expression using the cAMP signaling pathway. This research project is addressed to identify genes induced following application of CRF in an anterior pituitary cell line as well as in an immortalized LC neuronal cell line using the differential display technique. The identification of CRF-responsive genes may be important in elucidating mechanisms by which stress triggers and sustains the biochemical alterations associated with stress-related disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Darker Shades of Black. The Value of Skin Colour in the Mediterranean and Atlantic Slave and Labour Markets, 1750-1886' (2014-2020).

assistant: **Innovation**

Shades of Black proposes a new approach to the problem of race, a connected and global history which gives skin colour a fundamental role in determining the economic value of captives, slaves and free men of colour in the century of abolition. The objective is to examine how the skin colour of captives, slaves, serfs, workers on galleys and sex workers affected their value in economic transactions before and after the legal abolition of slavery in the period 1750-1886. The value of captives and slaves in the Mediterranean and the Atlantic changed according to the qualities they were assigned. My hypothesis is that skin colour and shades thereof were a major factor in influencing both the slaves’ exchange value and the salary level of free workers. I want to find out from the sources whether there was a correlation between the market price of slaves and the skin colour that was attributed to them by vendors, buyers and intermediaries. If confirmed, the colour black and its shades established a form of differentiation or discrimination among the workforce. I will compare experiences in countries of the Southern Mediterranean with those in the colonies of the French and Spanish Empires. For the Mediterranean, my case studies focus on the Italian area, France and Spain, and on Cuba and the French Antilles for the Atlantic. The period chosen allows analysis of, first, a period of growth in the trafficking of slaves and captives on the Mediterranean coasts, during and after the decline of the Atlantic trade, and then the consequence of the abolitions of slavery within geographical spaces characterised by accelerating mobility of persons of colour with different juridical statuses. Shades of Black entails the first study of the connection between the economic value and the phy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Muslim voices in the european union: the stranger within communit y,identity and employment'.

assistant: **Innovation**

This Project starts from the premiss that public discourse and policy-making have converged recently, so as to highlight some of the negative effects of the drive to enhance economic growth and competitiveness", and in particular the manner in which this may have contributed to an increase of the "social exclusion and marginalisation" for different groups within the European Union. This concern has also focused attention on the need to produce new knowledge on both the forms and processes of "social exclusion", that can contribute to the initiation of policies that will enhance "social cohesion" and effective processes of "social re-integration", and thus contribute to "sustainable economic development". This Project will engage in this debate, and intends to make a contribution, by presenting an analytical and comparative account (Belgium, Britain, France, Germany, Greece, Holland, Italy and Switzerland), of a particularly important and increasingly "visible" European ethno-religious community, which exemplifies many of the "characteristics" of social exclusion and marginalisation, namely the European Muslims. The changing structure of European employment, and especially the drive to attain greater "flexibility" in employment relations, thus encouraging "informal" employment practices, will constitute a particular focus. Thus, the Project will explore simultaneously, increasing "flexibility" in employment practices and the increasing "social exclusion and marginalisation" of European Muslims, seeking to determine the relationship between the two. This will be achieved by ascertaining the degree to which European Muslims are involved in "flexible" employment practices and in which areas of the European economy, delineating which European Muslim social categories are pri