RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Revisiting immunomodulatory functions of IL10 by examining human knock-outs' (RIFEK) targeting Seventh Framework.

assistant: **Abstract**

ObjectivesWe have discovered that early-onset inflammatory bowel disease (IBD) can be caused by mutations in IL10 or its receptor. This project aims to identify further patients suffering from IL10/IL10 receptor deficiency and to clarify the pathomechanism causing the severe phenotype of the patients.DesignThe project will investigate patients with early-onset IBD. Patients will have blood samples taken, white blood cells will be separated, DNA isolated and functional assays and genetic analyses carried out. Intestinal tissue samples will be stained by using immunohistochemical methods.Methodology:We will investigate different stages of IL10/STAT3 signalling in patients' white blood cells using ELISAs and/or Western blot; abnormalities will be confirmed by gene sequencing.Treg cells and Th17 cells will be analysed using flow cytometry or immunohistochemistry; function of Treg cells will be examined using commercially available tests. The role of cytokines other than TNF will be examined by challenging cells with different stimuli and subsequent analysis using chemiluminescence-based cytokine arrays. Neutrophil function and apoptosis will be examined using cytokine arrays, expression of pro- and anti-apoptotic proteins using Western blot and real-time PCR. Investigation of therapy resistance to immunosuppressive drugs includes analysis of NF-kB and NFAT pathways and, if necessary, the use of gene expression assays.Scientific and medical opportunities of the studyThis project may (i) identify further patients with IL10- or IL10 receptor deficiency; (ii) clarify the role of Th17 and Treg cells in the intestine of IL10/IL10 receptor deficient patients; (iii) investigate the role of cytokines other than TNF in the pathogenesis of the disease, (iv) shed light on the impact of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Causality Relations Using Nonlinear Data Assimilation'.

assistant: **Innovation**

A major problem in understanding complex nonlinear geophysical systems is to determine which processes drive which other processes, so what the causal relations are. Several methods to infer nonlinear causal relations exist, but often lead to different answers, often perform hypothesis testing on causality, need long stationary time series, can be misleading if an unknown process drives the processes under study, or, if a numerical model is used, reflect model causality instead of real-world causality. Furthermore methods that use the governing evolution equations directly lead to intractable high-dimensional integrals.In this proposal I will tackle these problems by firstly embedding causality into a Bayesian framework, moving from testing causality to estimating causality strength and its uncertainty in a systematic way. Knowledge from several causality methods can be combined, new knowledge can be brought in systematically, and time series can be short.   Furthermore, new knowledge can be incorporated into the existing knowledge basis, and several methods can be combined in a consistent manner. Secondly, a new formulation to infer causal strength exploring evolution equations that avoids high-dimensional integrals will be explored. Thirdly, numerical models are combined with observations by exploring fully nonlinear data assimilation to study real-world causality.I will test the new techniques on simple models and then apply them to a high-resolution model of the ocean area around South Africa where the Southern Ocean, the Indian Ocean, and the Atlantic Ocean meet.This area plays a crucial role in the global circulation of heat and salt by bringing warm and salty Indian Oceanwater into the Atlantic in a highly turbulent manner. The techniques allow to infer what sets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Network of competencies and platforms for Enabling SME from any sector building Innovative CPS products to sustain demand for European manufacturing' (EuroCPS) under Horizon 2020.

assistant: **Objectives**

SMEs play a key role in European economies; they constitute the largest business block and provide the bulk of employment. They generate most of the innovative ideas for ICT and CPS-enabled IoT products, two areas which represent an inflection point for innovators and industry in Europe.  EuroCPS is an ambitious project that aims to arm Europe with a network of design centres that will boost and initiate synergies between SMEs, major CPS-platforms, and CPS-competency providers, to capture the emerging markets for IoT products. EuroCPS will1. Leverage the existing regional ecosystem across the full value chain (from micro-electronics, smart systems, and CPS, to high value added products and services) and range of expertise and competencies to provide innovators from any sector with an easy path to build innovative CPS-enabled systems. 2. Act as a one-stop-shop that provides a critical mass of technologies and competencies by facilitating user-supplier partnerships across value-chains and regions. Hence the typical development time of innovative for CPS applications will be significantly decreased through the ease of access to the platforms, and coaching by the competence partners within EuroCPS.3. Link software, system and nano-electronic industries along the full CPS value chain to demonstrate a new cooperation model evidenced by experiments initiated and led by innovators that translate the rich pool of ideas from end users into implementation of CPS applications made in Europe. EuroCPS gathers major European system suppliers and world class research centres and technology providers, all rooted in the top European regional ecosystems. Based on strong foundations in European and national initiatives, EuroCPS will, through pan European collaboration and knowledge exchang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Spin Wave Computing for Ultimately-Scaled Hybrid Low-Power Electronics' (CHIRON).

assistant: **Innovation**

The future miniaturisation of electronic circuits following Moore’s law will require the introduction of increasingly disruptivetechnologies to limit power consumption and optimise performance per circuit area. CHIRON envisions spin wave computingto complement and eventually replace CMOS in future microelectronics. Spin wave computing is a paradigm-shiftingtechnology that uses the interference of spin waves for computation. Spin wave computing has the potential for significantpower and area reduction per computing throughput while reducing cost by alleviating lithography requirements. As a firststep towards the vision of a full spin wave computer, CHIRON envisions hybrid spin wave–CMOS circuits that can be readilyintegrated alongside CMOS.CHIRON targets a proof of principle of the essential elements for spin wave computing by an interdisciplinary approachjoining partners with expertise in material science, physics, nano-manufacturing, electrical engineering, device simulation,and circuit design. CHIRON will fabricate basic logic gates, such as inverters and majority gates, demonstrate theiroperation, and assess their performance. As transducers between the CMOS and spin wave domains in hybrid circuits,CHIRON will develop magnetoelectric and multiferroic nanoresonators, based on nanoscale bulk acoustic resonators, whichbear promise for high energy efficiency and large output signal. The targeted lateral scale (100 nm) and resonancefrequency (>10 GHz) bring such resonators to the frontier of nano-electromechanical systems (NEMS).This technological proof of principle is complemented by the design of digital hybrid spin wave–CMOS circuits that show theadvantages of spin wave computing and can be integrated into a CMOS environment. Based on calibrated compact devicemodels, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Fluorinated Lipid Nanoparticles for Gene Delivery and Diagnostics'.

assistant: **Objectives**

The formulation of drug nanocarriers has attracted increasing attention over the last decades. In particular, the possibility to combinetherapeutic and imaging functionalities in a single nanoplatform (theranostic) has been widely explored to advance therapeuticapproaches and promote the transition from conventional medicine to personalized medicine.Drug nanocarriers, holding the potential to produce a revolution in medicine, are lipid nanoparticles (LNPs) for gene delivery. Theyhave proven versatility and efficacy even though today it is still not possible to predict and control their cellular uptake and targeteddelivery. One of the main unmet challenges of LNP formulations is increasing their cellular uptake and gene release into the cytosol.Currently, it is possible to follow the fate of LNPs after administration only with the addition of labels (e.g., fluorophore) or specificribonucleic acid (RNA) sequence encoding for fluorescent protein. This results in the lack of possibility to follow the fate of LNPs onceadministered in vivo with a non-invasive imaging technique. Theranostic strategies to deliver RNA and simultaneous imaging oftarget organs is an important unmet goal.Recently, it has been demonstrated that fluorination of components in gene delivery vehicles strongly improved their cellular uptakeand, most importantly, their gene endosomal escape. The fluorination strategies investigated so far use either -CF3 groups or longlinear perfluoroalkyl chains, but a tailored design of the fluorinated group could also endow the nanocarrier with excellent imagingfunctions. In this context, FluoNeeD strategy is to tailor fluorination of LNPs in order to: (i) improve their therapeutic efficacy byenhancing LNP cellular uptake and promoting gene endosomal escape; (ii) rende
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Network for the Study of Orphan Nephropathies' (EUNEFRON).

assistant: **Innovation**

In this proposal, we have mobilized a critical mass of expertise to investigate, on a Europe-wide scale, the natural history and pathophysiology of rare inherited diseases affecting important structures of the kidney. The project will use and develop multiple models (in vitro and in vivo) with the aim to develop preventive, diagnostic and therapeutic interventions that should alleviate the burden of these diseases, particularly in children. A central part of the proposal is the creation of a European registry and a network of genetic laboratories to foster a tight interaction between physicians and researchers, promote clinical and basic research, and ensure the efficient dissemination of knowledge. By increasing our knowledge of these rare diseases, the EUNEFRON project will also yield new insights into basic processes relevant for the general population (progression of renal disease, blood pressure control, prevention of renal stones, effect of gender and ageing, etc…), the complex relationship between different nephron segments, and the multi-systemic involvement of renal diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Probabilistic Foundations for Networks' (ProFoundNet) targeting Horizon 2020.

assistant: **Abstract**

In an ever-connected world, increasingly complex network systems play a crucial role in many daily tasks. This results in an acute need for methods/tools that can enable easy control of the network and, at the same time, provide rigorous guarantees about its behavior, performance, and security. Recent years saw the growth of a new software ecosystem -Software-defined networking (SDN)- which advocates a clean and open interface between networking devices and the software that controls them.  Yet, existing SDN languages do not support reasoning about crucial quantitative aspects, such as: ``How much congestion is there?'' or ``Is the network resilient under failure?''. Enabling compositional quantitative reasoning is the major breakthrough needed to fully realize the vision of SDN. The central objective of this project is to develop new abstractions for programming of networks, with high-level modular constructs. We will provide rigorous semantic probabilistic foundations, enabling quantitative reasoning. This will serve as a solid platform for program analysis tools where compositional reasoning about complex interactions will be a reality. Our goal will be achieved through an interdisciplinary research effort: using techniques from concurrency and formal methods, areas where akin challenges can be found in the quest to design correct software systems. We will leverage the wealth of recent advances in those areas (some of which from the PI's own research) to networks, and bring awareness and new challenges arising from applications in networking to the other two communities. The project will significantly advance the foundations of network programming/verification in new and previously unexplored directions. This line of research will not only result in fundamental theor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'CD8+ T cell metabolism in anti-tumor response'.

assistant: **Innovation**

Although cancer immunotherapy has achieved significant breakthroughs in recent years that has positioned it as the most promising approach to treat cancer, its overall efficacy remains limited in the majority of patients. Nutrition-deprived conditions at tumor microenvironment poses significant metabolic challenges to tumor-infiltrating lymphocytes which may contribute to failure of anti-tumor activity. The main objective of the Immunometabolomics project is to understand metabolism in CD8+ T cells, during active effector T cell development and exhaustion, using approaches that go beyond current research which have been mostly focused on glucose/energy metabolism thus disregarding the relevance of anabolic and redox reactions that are crucial in correct cellular function and proliferation. Open-ended metabolomics and metabolic flux analysis studies, in combination with genetic, nutrition and pharmacological manipulations will be employed to study areas of metabolism that have not been previously extensively studied in CD8+ T cells including 1C metabolism. The characterization of metabolism in CD8+ T cells will be gradually performed in models of higher complexity and physiological and clinical relevance from in vitro, to in vivo in genetically engineered mouse models of lung cancer and finally in lung cancer patients. Through understanding CD8+ T cell metabolism, and its modulation in cancer within tumor microenvironment, we aim to develop a basic science foundation for increasing immunotherapy efficiency in cancer through the use of complementary nutritional and/or metabolism-targeted pharmacological approaches.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Metabolic characterization of ILCs under homeostatic or stress conditions.'.

assistant: **Concept**

Innate lymphoid cells (ILCs) are the most recently identified components of the innate immune system. ILCs colonize mainly mucosa-associated tissues and they have a crucial role in metabolic homeostasis, and defense against infections and cancer. ILCs are highly plastic and they rapidly shape their functional output in response to local environmental cues. Two ILC subsets (ILC2 and NK cells) have been respectively implicated in the maintenance of adipose tissue homeostasis and in the development of chronic inflammation in obese patients. It has been shown that cellular metabolism affects the development and function of adaptive lymphocytes. In contrast, very little is known about innate lymphocytes metabolic requirements under homeostatic conditions and how they metabolically adapt to environmental perturbations.This project will study metabolic profiles in human ILC subsets isolated from the bloodstream, lymphoid and non-lymphoid tissues under healthy conditions and inflammatory disease states. Whole-genome transcriptomes, proteomes and metabolomes will be compared in order to decipher the pathways that regulate ILCs. A better understanding of the metabolic network that govern ILCs in steady state and how these cells “switch” their metabolism to exert their function, may ultimately reveal novel targets for the treatment of chronic inflammatory diseases and metabolic disorders, like obesity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bioarchaeology of Orchards and Sustainable Terroir in the Arid Near East – Trends in Ecology and Evolution' (2021-2027).

assistant: **Innovation**

Engaging with the myriad challenges linked to global warming and the unchecked expansion of drylands, the project seeks to develop models for implementing past agricultural know-how in modern socioeconomic contexts. Our novel methodology fuses cutting-edge interdisciplinary scientific approaches from the humanities and natural sciences with an inclusive citizen science framework to examine the ecological history and cultivar diversity of relic ‘heritage horticulture’ in four distinct arid regions in southern Israel. Focusing on the bioarchaeology of trees, we will define the historical, biological and environmental principles of dryland heritage horticulture systems and create a method for the exploration, analysis and ultimate dissemination of the crucial data they contain. When combined, this exceptional compendium of perspectives—coupling broad socio-geographical scientific viewpoints with more precise biogenetic, archaeological, and natural science analytics—can expand our understanding of the factors that drove the sustainability of heritage horticulture in marginal areas. The outcome of our study—an archaeologically informed grasp of ancient agrarian resilience—can transform the field of environmental history and impact present-and-future agricultural dynamics. Indeed, viewing trees as a singular analytical unit is unprecedented, as is our interdisciplinary survey of both the dormant and living artifacts contained within these archaeological contexts. Hence, deep knowledge of how bygone farmers related to the landscape and managed their limited resources, particularly the terrain, soil and water, holds vital implications for climate change adaptation and current-day food security. Moreover, the unique history of dryland farming and its remarkable development in ma