RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamical tests of dark matter in Local Group galaxies: shortcomings and new avenues' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The distribution of dark matter in the Milky Way and neighbouring Local Group galaxies is an important indicator of the nature of dark matter. Accurately determining the smooth distribution of dark matter in these galaxies and the degree of clumpiness (abundance of luminous and dark satellites) encodes information about the properties of dark matter and the interplay between the baryonic and dark sectors in the formation and evolution of galaxies. As well as being auxiliary quantities in interpreting the results of multichannel dark matter searches. Thanks to significant investments in observational resources by international and, in particular, European countries, we now have access to an enormous amount of detailed, high-quality astronomical data that allow us to view Local Group galaxies as complex systems in interaction with their environment. The DiaLoGues project will help harvest these exquisite data's full potential in interdisciplinary dark matter searches with a hybrid approach. On the one hand, we will address biases in the smooth, galactic-scale distribution of dark matter in current chemo-dynamical models of the Milky Way and neighbouring dwarf galaxies. On the other hand, we will search for peculiar features in the spatial distribution and kinematics of individual stars in Local Group dwarf galaxies, which will then be confronted with signatures of luminous and dark mergers in state-of-the-art hydrodynamical simulations. In this way, the theoretical link between observations and the accretion history of the host dwarf galaxy will be provided. DiaLoGues will be a transfer-of-knowledge agent between the astroparticle and astrophysics communities, contributing to the interdisciplinary endeavour to constrain the underlying particle physics model that governs d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Natural course, pathophysiology, models for early diagnosis, prevention and innovative treatment of TNF Receptor Associated Periodic Syndrome TRAPS with application for all hereditary recurrent fevers' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The TNF Receptor Associated Syndrome (TRAPS) is a rare disease of innate immunity, caused by mutations in TNFR1. It is characterised by recurrent bouts of fever and pain and mainly affects patients of European ancestry. The development of renal amyloidosis in up to 20% of cases makes it a potentially fatal disease. Corticosteroids and anti-TNF therapeutics have not been consistently effective in controlling attacks and preventing amyloidosis. EUROTRAPS is a multidisciplinary consortium, which by combining ideas, resources, and data from 7 academic participants and 2 SMEs from 6 countries, aims to gain insights into the natural course and pathophysiology of TRAPS, particularly in children. The creation of a European registry for TRAPS patients will facilitate the delineation of scores and outcome measures for diagnosis and treatment. We will examine additional pathways and genes involved in the phenotype. Kit assays will be developed to facilitate identification of disease mutations and susceptibility factors for amyloidosis and resistance to treatment. TNFR1 signalling, apoptosis and IL1 secretion abnormalities associated with TRAPS will be studied. We will also develop in vitro and humanised animal models to investigate innovative therapies. We expect that future developments in TRAPS will impact on all aspects of hereditary paediatric fevers, and thereby improve the wellbeing of patients and their families. A dedicated bipartite committee will undertake the complex task of managing this ambitious project, create a secure intranet, organise regular meetings, issue progress reports, oversee ethical, legal, financial, and gender issues (over 50% of the participants are female), adjust the workplan at each milestone, and guarantee dissemination, exploitation and protectio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Programmable Digital Gyroscope of High Performance and Low Cost' under Fifth Framework.

assistant: **Concept**

The goal of PRODIGY is a programmable, high performance gyroscope with an accuracy better than 0,02 °/s and a price below 10 EURO.Three selective measures will be applied:1. New integrated MEMS technology based on DRIE and special SOI substrates2. New design principles3. New digital readout electronics.One partner will implement the sensor into an advanced path prediction system, which will guarantee its immediate usability. Due to its high adaptability the gyroscope will be a key component for many products, e.g. in the fields of advanced automotive safety and comfort systems, people-to-device and people-to-people communication, virtual and augmented reality. To stay competitive with worldwide suppliers a joint European effort is necessary as proposed with the consortium consisting of a leading car manufacturer, Silicon foundry provider, supplier of silicon devices and systems, and an R&D institute with a well known gyro group.Objectives:The goal of PRODIGY is to develop a programmable, high performance gyroscope with an overall accuracy better than 0,02 °/s and a price below 10 EURO. The sensor will be implemented in an advanced path prediction system, which will contribute to resolving the problem of security and comfort of car drivers caused by the increasing traffic rate. Due to the high adaptability of the sensor many other applications are addressed, e.g. in the fields of virtual/augmented reality, people-to-people and people-to-device communication (gloves, helmets, mobile phones), robotics (home robots, autonomous guided vehicles), medicine (surgical instruments) and consumer. In addition PRODIGY will contribute to the overdue standardization for gyroscope specifications and enhance the European technology base by offering the MEMS technology in the framework o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative End-to-end Management of Dynamic Manufacturing Networks' (IMAGINE) targeting Seventh Framework.

assistant: **Abstract**

Effective end-to-end management of dynamic manufacturing networks is consistently touted as a top priority for manufacturing enterprises that need to strive to improve their efficiency, adaptability and sustainability of their production systems. Moreover, it is a crucial prerequisite for the emerging powerful new model of production based on community, collaboration, and self-organisation and openness rather than on hierarchy and centralised control. IMAGINE addresses the need of modern manufacturing enterprises for a novel end-to-end management of dynamic manufacturing networks and will develop a multi-party collaboration platform for innovative, responsive manufacturing that encompasses globally distributed partners, suppliers & production facilities (SMEs and/or OEMs) that jointly conduct multi-party manufacturing. The project will implement a novel comprehensive methodology for the management of dynamic manufacturing networks that provides consolidated and coordinated view of information from various manufacturing sources and systems and enables service-enhanced product and production lifecycle and responsive manufacturing processes throughout the value chain. Living Labs in major industrial sectors will drive the implementation, testing, evaluation and dissemination of the IMAGINE methodology and supporting ICT platform. The IMAGINE manufacturing model is an innovative plug and produce approach that implements an end-to-end manufacturing interoperability solution. The IMAGINE solution is market-oriented with focus on value chain streamlining and support for emerging manufacturing business models. IMAGINE promises to have a profound and long lasting impact on EU manufacturing enterprises to adapt to global competitive pressures by providing the technological base t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New manufacturing infrastructure for the production of high quality Natural Fibres' (ULTRAFIBRE).

assistant: **Innovation**

Natural fibres offer a route to the production of sustainable composites, replacing inorganic and petrochemical based fibres with high-embodied energy. One of the main obstacles to the exploitation of natural fibres is the limited consistency of supply, with batch-to-batch variations in quality. Retting – a process whereby plant stems are left to weather in the fields – has been identified as being the weak point in fibre processing in the as a result of variable weather conditions during the retting period. Mechanical decortication – the removal of the outer layers – is often damaging to the fibres. UltraFibre will develop a clean processing technology called ‘hydroacoutstic decorticaton’ to extract the fibre from the plant after harvesting avoiding reliance on degree of dew retting. The fibre produced will be of much higher quality, without the physical damage caused by mechanical decortication, circumventing reliance on unpredictable weather for completion of dew retting in fields. Chemical treatments have been used to modify fibres to improve matrix to fibre adhesion in composite materials. However, these chemical treatments use hazardous materials, are time-consuming and create a significant level of waste. Therefore, a treatment process that does not pose a threat to the natural environment and that is reproducible, whilst creating little or no hazardous waste, would be extremely advantageous. To achieve this end, UltraFibre will develop a ‘soft plasma’ treatment process that will integrate with the hydroacoustic decortication process to produce high quality fibre for the rapidly expanding composites materials sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A paradigm for the establishment of new prognostic markers for common cancers: protease systems as indicators of invasive potential.' (PROTEASES).

assistant: **Concept**

A rational approach to focused adjuvant therapy is urgently needed in the management of patients suffering from the most common cancers; the ability to identify patients at high risk would enable most cost-effective use of the treatments available. This proposal assembles a collaborative effort from seven leading European cancer research laboratories to identify new prognostic marker sets based on a systematic exploration of tissue protease systems functionally involved in tumour progression. The partners will apply state of the art molecular biology to identify the most relevant novel proteases, before embarking upon their quantitative measurement in large collections of patient material. The clinical studies for assessment of prognostic significance will examine the prognostic significance of each marker and derive marker sets, which optimise prognostic power. Commercially attractive kits will be assembled for the new marker sets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Regulation of expresssion and function of hfe, a novel regulatory protein of iron homeostasis : production of new tools to hereditary hemochromatosis and associated chronic diseases.'.

assistant: **Objectives**

HFE molecules have a pivotal role in controlling iron metabolism, as best exemplified by classical hereditary hemochromatosis, the most common hereditary disorder in European populations. Tools have been and will be developed (i.e. HFE specific monoclonal antibodies, KO and HFE transgenic mice) in the clustered laboratories to define HFE expression and mode of action in normal tissues and malignant cells, in cell activation, in virus-infected cells (specially with chronic viruses such as hepatitis), and in various iron-overload related pathologies. Complementary approaches (characterization of HFE promoter, biochemistry of HFE, iron metabolism exploration, cellular employ) will be combined for a comprehensive resolution of iron metabolism control. A particular effort to dissect the connections that exists between iron metabolism, HFE, and immune system, will be made. Experimental tools and gained knowledge will be utilized to explore human pathological situations associated with iron disorders, their early diagnosis and the development of novel therapeutic modalities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural studies of lysyl-trna synthetases', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Aminoacyl-tRNA synthetases are ubiquitous enzymes which are responsible for the fidelity of the translation of the genetic code. The three-dimensional structures of these proteins are important since they enable us to address a number of questions about their function, and to understand how do they recognise the correct amino acid and how can discriminate between various tRNAs of similar shape and size. A comparison between the structures of evolutionary related synthetases can help to answer questions about the way this family of enzymes and the genetic code have coevolved. E. coli produces two isoforms of Iysyl-tRNA synthetase, a class II aminoacyl-tRNA synthetase: LysS is the constitutive enzyme, while LysU is the product of an inducible gene. The crystal structure of the thermoinducible LysU with Iysine bound to the active site has been determined to 2.8A resolution and compared to other class II synthetases. More work is needed in order to study the reaction mechanism and to analyse the interactions made by ATP, the Iysyl-adenylate intermediate and the tRNA. The structure of the highly homologous LysS was determined in the absence of any substrates. The project will involve the structure solution and refinement of LysU and LysS in the presence of various substrates and inhibitors, at the highest possible resolution. The structures will then be analysed and compared to identify conformational changes or differences between isoforms of physiological and biochemical relevance. A comparison with other class II synthetases for which crystallographic models of substrates bound to the active sites are known, will also be carried out, in order to determine differences and similarities that rnight have evolutionary implieations. We will use in vitro transcription to produce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'A Multiscale Dislocation Language for Data-Driven Materials Science'.

assistant: **Innovation**

Crystalline defects in metals and semiconductors are responsible for a wide range of mechanical, optical and electronic properties. Controlling the evolution of dislocations, i.e. line-like defects and the carrier of plastic deformation, interacting both among themselves and with other microstructure elements allows tailoring material behaviors on the micro and nanoscale. This is essential for rational design approaches towards next generation materials with superior mechanical properties.For nearly a century, materials scientists have been seeking to understand how dislocation systems evolve. In-situ microscopy now reveals complex dislocation networks in great detail. However, without a sufficiently versatile and general methodology for extracting, assembling and compressing dislocation-related information the analysis of such data often stays at the level of “looking at images” to identify mechanisms or structures. Simulations are increasingly capable of predicting the evolution of dislocations in full detail. Yet, direct comparison, automated analysis or even data transfer between small scale plasticity experiments and simulations is impossible, and a large amount of data cannot be reused.The vision of MuDiLingo is to develop and establish for the first time a Unifying Multiscale Language of Dislocation Microstructures. Bearing analogy to audio data conversion into MP3, this description of dislocations uses statistical methods to determine data compression while preserving the relevant physics. It allows for a completely new type of high-throughput data mining and analysis, tailored to the specifics of dislocation systems. This revolutionary data-driven approach links models and experiments on different length scales thereby guaranteeing true interoperability of simu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The first multi-messenger detection of a supermassive black hole binary', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Supermassive black hole binaries (SMBHBs) are a natural outcome of galaxy mergers. They can be identified as quasars with periodic variability in time-domain surveys, or from strong gravitational waves (GWs) by Pulsar Timing Arrays (PTAs), making them exceptional multi-messenger sources. Despite their expected ubiquity, they have remained undetected, but upcoming data of unprecedented quantity and quality from the Legacy Survey of Space and Time (LSST) and increasingly more sensitive PTAs will bring these multi-messenger monsters (MMMonsters) within reach.MMMonsters at the intersection of astronomy and data science is an ambitious program to deliver the first multi-messenger detection of a SMBHB. Leveraging existing time-domain data, we will improve SMBHB searches advancing our understanding of binary signals and quasar noise. For the first time, we will search for more complex and likely more common non-sinusoidal periodicity. Using the LSST Data Previews, I will develop novel machine learning tools to capitalize on the LSST dataset. With advance preparation, MMMonsters will be poised to reliably detect binaries in the first few LSST data releases, making the project extremely timely and impactful.On the GW side, I will pave the way for the first PTA detection of an individually resolvable binary. I will build novel PTA detection pipelines that directly incorporate EM data, from a catalog of 20 million galaxies (which we will compile) including all the potential binary hosts. My approach will accelerate the first detection of a SMBHB and allow the subsequent identification of the binary host galaxy. I will forge the ultimate boost in binary detectability through the joint analysis of time- domain and PTA data in a multi-messenger data stream.MMMonsters will establish s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demonstration of an optimised production system for biogas from biological waste and agricultural feedstock' (AGROPTI-GAS) under Fifth Framework.

assistant: **Objectives**

Many cities are looking for vehicle fuels and waste management systems that are environmental friendly and cost effective. At the same time many regions has a vulnerable agriculture with need for higher competitiveness. This full-scale system for co-digestion of biological municipal waste, lay crops and manure will demonstrate a new way to meet these needs. A new process technique that allows a unique low water content will enable a cost effective production and distribution system. The objectives are to demonstrate: 1. A process technique with new components where energy crops, municipal biological waste and manure is co- digested at a total solids concentration of ca 9-15%. 2. An infrastructure with new components for storing and distribution of the different materials to and from the biogas plant. 3. Competitive as vehicle fuel and waste management system. 4. Advantage for the farmer to be part of the system.