RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Atomically dispersed iridium catalysts for efficient and durable proton exchange membrane water electrolysis' (AdIrCAT).

assistant: **Innovation**

The “green hydrogen” produced by water electrolysis using renewable energy as power input will play a vital role in the decarbonization of various sectors, particularly the heavy industry and freight road transport where electrification is impossible or too costly. Proton exchange membrane water electrolysis (PEMWE) is a very promising low-temperature technology, and has a number of advantages over the conventional alkaline water electrolysis. However, the usage of precious and scarce noble metal iridium (Ir) to catalyze the thermodynamically and kinetically demanding oxygen evolution reaction (OER) is indispensable to achieve decent electrolysis performance. To enable widespread deployment of PEM electrolyzers and make electrolyzed hydrogen fuel economically competitive, the utilization of Ir in electrolyzers must be reduced without comprising the catalytic performance for the OER. The AdIrCAT project aims at developing the emerging atomically dispersed Ir catalysts, which will maximize the utilization of Ir and meanwhile improve the mass activity of Ir catalysts by a factor of at least 5. Moreover, a method will be developed that potentially allows for upscale production of atomically dispersed Ir catalysts. The catalysts will be accessed not only in the half-cell configuration but also in membrane electrode assemblies under industry-relevant conditions in collaboration with a company where the applicant will have her secondment. The applicant and host group have complementary expertise that can be transferred to each other. The host institution will offer the applicant a range of training to enhance her competences and skills in terms of proposal preparation, project management, leadership, and science communications. Successful implementation of this project will he
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Supporting a person in what (s)he is? An empirical assessment of Honneth's theory of recognition in the light of the encounter with intellectual disability (Down's syndrome and fragile X syndrome)' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The research consists in an empirical test of key statements related to the theory of recognition (Anerkennung) of Axel Honneth. Recognition (Anerkennung) being the fact of supporting a person in what she or he is". I consider testing Honneth's theory along three questions: (1) What contributes to the process of recognition (Anerkennung)? (2) What are the consequences of recognition (Anerkennung)? (3) What is recognition (Anerkennung) applied to? Each of these questions relates to a set of hypotheses, that either suggest a view that is different from what Honneth's theory describes or relate more tightly to everyday social context The theoretical framework of the proposed research is French pragmatic sociology, that provides concepts for analysing ordinary judgements. The inquiry focuses on the case of persons with intellectual disabilities, because industrial societies, by demanding individual autonomy and economic competitivity, remain extremely excluding for them, and the encounter between a person with such a disability and an "ordinary" person displays major individual differences. I plan a qualitative inquiry based on in-depth semi-structured interviews, recorded and systematically fully transcribed. All of the 9 hypotheses to be tested can be addressed through interviews with parents and with care or education professionals. In order to identify the role played by the legal and institutional environment as well as by the cultural representations, the inquiry includes three countries: France, Belgium and Germany. This research shall contribute to an empirically grounded theory of justice and ethics, in line both with the ambition of Prof. Axel Honneth to carry on the tasks of the Critical Theory and improve our understanding of justice and conflicts in contemporar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Augmenting PBGD expression in the liver as a Novel Gene therapy for Acute Intermittent Porphyria' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Acute intermittent porphyria (AIP) is a rare genetic disease in which mutations in the porphobilinogen deaminase (PBGD) gene produce insufficient activity of a protein necessary for heme synthesis. This leads to an accumulation of toxic intermediates resulting in a wide variety of problems including acute, severe abdominal pains, psychiatric and neurological disorders, and muscular weakness. Acute porphyric attacks can be life-threatening and the long-term consequences include irreversible nerve damage, liver cancer and kidney failure. AIP affects 1/10,000 people in the EU and the therapies currently available do not prevent the symptoms or consequences of acute porphyric attacks. The only curative therapy is liver transplantation and thus, new curative options are clearly needed. In 2009, the European Medicines Agency granted Orphan Drug Designation to AAV5-AAT-PBGD for the treatment of AIP. AAV is a replication-incompetent virus that has been modified to deliver genes or genetic material into human tissues or cells. AAV5-AAT-PBGD acts by delivering the PBGD expression cassette directly into hepatocytes. In heterozygous AIP patient that show 50% of the normal activity the additional PBGD activity will be sufficient to prevent the accumulation of toxic metabolites and thus, to prevent porphyric attacks. the aim of this project is the clinical development of the orphan drug AAV-AAT-PBGD for use to treat AIP. The project will be performed in three different phases. In the first phase, we will develop a GMP-compliant process to produce sufficient AAV5-AAT-PBGD for clinical trials, and we will constitute the largest possible cohorts to improve the follow-up of patients and determine the clinical criteria to select patients for gene therapy. In the second phase, the safety a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Improving National Assessment and Monitoring Capacities for Integrated Environmental and Coastal ecosystem Management'.

assistant: **Concept**

The proposal contributes to increase Lebanon’s capacity in important environmental concerns based on a regional approach that assess the anthropological impacts on natural resources. As a bottom up project, INCAM will first support collection of existing research data to assess the status of natural resources and identify knowledge gaps in environmental assessment capacities, especially in the intensively developed Lebanese coastal zones. A detailed action plan will be developed to strengthen institutional capacities of the Lebanese National Council for Scientific Research (CNRS) and convert it into a national and regional research centre of excellence. Further on, the project will enhance EU - Regional cooperation and networking by increasing the role of the EC in general and of the FP7 in particular. Special attention is given to training and dissemination. Two regional workshops on environmental institutional capacity building will be organised in Jordan and Egypt. This last event will tackle more deeply issues related to integrated coastal zone management and will be combined with the final project conference open to national, regional, international and EU stakeholders. Local dissemination and public awareness activities will be organised in critical “hot spot” areas in Lebanon, Jordan and Egypt. The project splits into six scientific work packages in addition to one that deals with coordination and management. The major outcome will be increasing the leading scientific role of CNRS and its centres and productive exchange of experts between the region and the EU. Short training courses will be organised for Lebanese researchers in the EU countries and young students will pursue MSc thesis in Italy. The project duration will be 24 months. The leading organization is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Extended electrostatic system for air purification' to be submitted under Fifth Framework.

assistant: **Abstract**

Gaseous contaminants e.g. sulphurdioxide, and air borne particles e.g. fungi spores are responsible for the deterioration of paper in archives and libraries. At present only high-cost air purification systems related to outdoor pollutants are available. This project aims to develop an innovative low/mid cost system for safe storage of paper based cultural heritage. The technical development claimed is the application of elelctrostatics. End-users will be involved in the evaluation of the system developed. RTD performers will be included for the applied scientific work. Results will be disseminated using specific Journals and presentations at e.g. EG conferences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Body schema learning and adaptation in the iCub humanoid robot using whole-body tactile information'.

assistant: **Concept**

State-of-the-art robotic technologies rely on preprogrammed models and largely lack the capacity to adapt to unexpected changes to their bodies or the environment. In order to expand the domain where they can be applied, they need to respond more autonomously, flexibly and robustly. The applicant will use the iCub humanoid robot, recently equipped with whole-body tactile sensing, to address these challenges by developing new methods to (i) autonomously acquire and adapt models of the complete robot’s body; (ii) move in unknown cluttered environments using whole-body awareness, thus preserving the robot and other people’s safety.The flexibility of humans can be, at least partly, attributed to the way the brain represents and updates the properties and current state of the body. However, the mechanisms of the so-called body schema are still not understood. Therefore, modeling and implementing body representations can serve to crystallize known biological facts and simultaneously design robot controllers which can perform with the reliability and adaptability of humans. The iCub robot with a human-like morphology and a corresponding set of sensory and motor modalities is a perfect tool for this task.The host institution - the Italian Institute of Technology - provides a unique environment that combines humanoid robot technology and cognitive science expertise under one roof, plus an outstanding training environment. The applicant will be able to capitalize on his background in cognitive robotics and crucially expand his research and complementary skills. He will directly participate in the transfer of iCub-related technologies to industry and in numerous outreach activities. Upon completion of the project, the applicant will acquire a unique but rare set of multidisciplina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Vitis and taxus species : stilbenes, phenols, transformed roots, cell cultures'.

assistant: **Innovation**

THE APPLICANT will get experience in the initiation and development of genetically transformed hairy" roots, as well in the manipulation of cell cultures initiated from woody plants of dicotyledonous (Vitas) and coniferous origin (Taxes). Confirmation of transformation could be carried out by DNA analyses. He will also get instruction on and experience with the isolation and identification (chemical and chromatographic) of plant secondary metabolites, including HPLC protocols for quantitative analyses. THE HOST INSTITUTION will gain from the expertise and experience, which the applicant has in the areas of somatic embryogenesis, protoplast isolation/culture and calcium dynamics of plant cell cultures. This is of special interest in the case of Taxes baccarat where micro propagation and embryogenesis have proved difficult. Also protoplast isolation from metabolite-rich and fast-growing strains of Taxes could be extended to include protoplast fusion to develop hybrids of commercial interest."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and Validation of Techniques for Brain Morphometry' (BIOMORPH), addressing dissemination and exploitation.

assistant: **Impact**

BIOMORPH is a project to develop improved techniques for measurement of the size and shape of biological structures (morphometry). Morphometry has become increasingly important since the advent of non-invasive magnetic resonance imaging which is providing large volumes of data from normal as well as abnormal individuals in vivo and allows time changes to be studied.The techniques to be developed are generic, but the project is focused on schizophrenia and multiple sclerosis, applications in neurology and psychiatry where the need for improved morphometric techniques is particularly clear. These are common diseases of great economic and social as well as medical importance. Even small advances in management could lead to substantial savings. In schizophrenia, changes in the morphology of various brain structures are thought to provide important clues to the most fundamental brain abnormalities that underlie the condition, but the changes are barely detectable with current techniques and more research is needed to confirm and extend existing data. In multiple sclerosis, quantification of changes in lesions has become of great importance for pharmaceutical trials, and improved morphometry would reduce the cost of developing new drugs.The basic requirements for improved morphometry are similar in the different applications. Measurement of size is hampered by the difficulties of detecting and localising the boundaries of structures in images (segmentation), particularly in three dimensions, but there have been recent advances in segmentation which could now strengthen morphometric studies. Experts regularly describe normal and abnormal shape in the language of anatomy and medicine but developing and validating computational techniques has proved difficult. In the BIOMORPH pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Characterization of zebrafish innate lymphoid cells and IL-22' to be submitted under Horizon 2020.

assistant: **Abstract**

The immune system can be subdivided into two main arms: the innate and the adaptive. Recently, it was identified a new family of cells belonging to the innate system but that phenotypically and functionally resemble the specific subtypes of adaptive T lymphocytes. In mice and in humans, these innate lymphoid cells (ILCs) play critical roles in host defense, in shaping the microbiota and in tissue repair at mucosal tissues via secreting cytokines such as IL-22. The innate system is more ancient than the adaptive, however, the existence and diversity of ILCs in organisms other than mammals remains unknown. Also unknown is how ILCs interact with other cells within tissues. This project will address the existence and role of the different subsets of ILCs and the conservation of IL-22 function in a distant relative, the zebrafish, a genetically tractable vertebrate with remarkable optical accessibility. To identify ILCs, cell populations likely enriched in these cells will be purified from mucosal sites such as the intestine and the gills by flow cytometry, guided by morphology and expression of reporter transgenes for immune cell types. Their transcriptome profile will be assessed in bulk and at the single-cell level adapting the microfluidic-based Biomark system to the zebrafish. Also, to know if cytokines produced by T cells can also be produced by non-adaptive lymphocytes – i.e., ILCs, as described in mouse, immune responses of zebrafish mutants lacking adaptive lymphocytes or all types of lymphocytes will be compared to that of wild-type fish. To study IL-22 function, mutants for this cytokine and its receptor will be generated. Together with a transgenic il22 reporter line allowing the identification of IL-22-producing cells, they will be challenged with pathogens or i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Biological procedures for diagnosing the status and predicting evolution of polluted environments' to be submitted under Sixth Framework.

assistant: **Abstract**

The objective of BIOTOOL is the generation and validation of novel conceptual and material instruments, rooted in biological processes, for diagnosing soil status and predicting evolution of contaminated soil and groundwater. The focus is on the assessment and evaluation of natural attenuation processes. This will require benchmarked monitoring tools and warning criteria to implement natural attenuation as the key groundwater and soil remediation strategy in Europe. It will be materialized through the application of a suite of state-of-the-art genomic, proteomic and analytical technologies to environmental samples and sites themselves. We will exploit the translocation of indicator chemicals from below ground into above-ground vegetation as a cheap and rapid monitoring tool for subsurface contamination. Diagnosis of the biological status and evolution models for polluted environments will be achieved through [i] the design and utilization of DNA and specifically DNA-array technology for examining the catabolic potential of any given particulate sample and [ii] the identification of protein biomarkers as descriptors of soil and groundwater quality and biological attenuation clocks.The progress in microbial community functional genomics and proteomics will be employed to gain a mechanistic understanding of prevailing stresses, global responses to chemical insults, plant/microbe interactions and microbial community adaptations that determine microbial-driven soil and groundwater processes. This will add a considerable predictive power to the genomic and proteomic approaches mentioned above. Determining the links between environmental factors and expression of degradation abilities will be crucial for strategies aiming at an optimal expression of the catalytic power of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Population context-dependent regulation of membrane lipid composition and downstream activities in mammalian cells: the FAK-ABCA1 system' (2007-2013).

assistant: **Concept**

The aim of this project is to uncover a novel regulatory mechanism that explains how cells change their membrane lipid composition and trafficking as a function of population context, and how that is used to adapt the cell’s physiology to its microenvironment. To do so, I will use single cell microscopy over large populations, lipidomic, phosphoproteomic and microarray analysis of mice cells deleted from Focal Adhesion Kinase (FAK).When cells grow at low local cell density or at the edges of cell islets, FAK becomes activated. This event activates signalling and gene regulation. Interestingly, silencing of FAK strongly impairs sphingolipid GM1 amount at the plasma membrane and fate through clathrin-independent endocytosis, leading to drastic diminution of Simian Virus 40 (SV40) infection.  Microarray analysis of FAK-KO cells and Wild Type, in dense and sparse contexts, shows that lysosomal, Golgi apparatus and trafficking genes are controlled by activated Focal Adhesion Kinase. ABCA1, a membrane scrambler and cholesterol efflux mediator, is the second overall strongest hit and the only membrane protein amongst the top hits. Strikingly the loss-of-FAK phenotype in cell spreading and growth can be reversed by inhibiting ABCA1, suggesting that FAK act on membranes by controlling ABCA1 production.I would like to characterise the actors and dynamics of the FAK-ABCA1 system to understand how it couples membrane composition and clathrin-independent trafficking to local environments. I will apply i)phosphoproteomic approach and chromatin Immunoprecipitation for finding key signalling axis from FAK activation to gene regulation, ii)lipidomic for characterizing FAK effect on membrane composition, and iii)leading edge single cell microscopy over large populations both in live or f