RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Assessment of community structure and seston quality effects on plankton carbon fluxes at two contrasting coastal sites' (PCFLUCS).

assistant: **Concept**

This proposal focuses on investigating carbon fluxes whithin coastal pelagic ecosystems under the hypothesis that fluxes can be modulated by both community structure and seston quality. The study considers estimation of selected carbon fluxes, mesurement of seston chemical composition, and determination of planktonic community structure at seasonal and sub-seasonal scales in two contrasting coastal sites: the Gullmarsfjord (Sweden, Incoming Phase of the project) and the Río de la Plata (Uruguay, Returning Phase). The fluxes to be estimated by a combination of field observations and field/laboratory experiments include microzooplankton grazing, mesoplankton grazing on phytoplankton and predation on heterotrophs, and carbon downward export due to sinking of phytoplankton, of mesozooplankton faecal pellets, and of other biogenic structures (carcasses, marine snow, etc.). Expected results are that the planktonic community structure will modulate certain carbon fluxes at a seasonal scale, but seston quality will be most important at sub-seasonal scales. Results will contribute to the understanding of pelagic ecosystem functioning and to the development of better management practices. Furthermore, training and experience acquired during the developement of this proposal will imply a transfer of knowledge with a very high potential impact for the developement of this line of research in Uruguay. The development of this proposal will also contribute to the establishment of effective scientific cooperation between the European Community and the third country.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Andasol 50MWe Eurotrough solar thermal plant with thermal storage in the Marquesado Valley (Granada, Spain)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

ANDASOL's main objective is the implementation of a privately owned and financed 50 MWe solar thermal power plant that will produce annually 181.7 GWhe of clean, emission-free solar electricity in Southern Spain. ANDASOL will demonstrate for the first time on a utility-scale two major innovative advancements of solar thermal technology: The EUROTrough technology and a 9hour thermal storage system. By this, the ANDASOL plant will be worldwide the first solar plant of such size that can provide firm and dispatchable solar electricity at night and during cloud periods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'ATS Level Business Jet 2035 Forecast'.

assistant: **Objectives**

The proposal addresses the topic: “ATS Level Business Jet 2035 forecast” (JTI-CS2-2016-CFP05-TE2-01-03) and it is devoted to perform forecasts for business jet traffic, in terms of fleet and movements starting from 2015, passing by 2020/2025/2030 until 2035, with a detail at country/region/world levels. Where gaps exist, an estimate will be made based on the methodology. More in detail the Technology Evaluator has requested: “The global fleet development and the share of European (Clean Sky) Aircraft” and “the development of movements per country and between Origin and Destination airports”. The overall objective of the project is: to analyse existing forecasts about volume and movements of Business jets in the relevant years, to establish a new forecast about bizjet fleet up to 2035 and the number of bizjet movements at country/region/world levels, to estimate the market share of European products in the market.Generally the forecast of business jet volumes depends on technology progress and the associated cost reductions, demand related to “Gross Domestic Product” development and accessibility. This means that the future of the bizjet transport also depends on developing new concepts of operation, aircraft concepts and business models and plans. After the assessment of the existing forecasts by different sources and CleanSky related actions and outcomes, the methodology of harmonization and improvement of the business jet forecast will be defined and finalized. The methodology based on a new dedicated demand equation will include: definition of the economic, technology and societal drivers, harmonized business models and business plan as well scenarios to create an improved forecast model. The outcomes will be completed in case of gaps and shared with the involved sta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European young scientist contest television series' under Sixth Framework.

assistant: **Concept**

An annual Television programme (2 x 30 or 4 x 15 minutes) in the framework of the European Broadcasting Union with the working title European Young Scientist Contest Television Series. The aim of the programme is: 1. to promote science among young people. 2. to increase awareness of science in Europe among the general public. The programme will show scientific research, career, education and background of the 4-6 awardwinners of the contest, which will be held in Valencia in September 2007.The programme will be recorded in the countries of the awardwinners on location and also include the presentations and the awardwinning ceremonies in Stockholm. It is the intention to broadcast the programmes in almost all European countries with the assistance of the European Broadcasting Union (Education and Science Group). In this proposal 9 participating companies guarantee already broadcasting. It will not be a problem to invite all the European public broadcasters in the Group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The development, validation and implementation of human systemic Toxic Equivalencies (TEQs) as biomarkers for dioxin-like compounds' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Chlorinated dioxins and biphenyls (PCBs) commonly occur in the human food chain and can still be detected at levels that might cause long term health effects. Exposure to dioxin-like compounds involves a complex mixture with a common mechanism of action involving endocrine, developmental, carcinogenic, immuno and neurological effects. Risk assessment is done with an additive model for mixture toxicity. Based on this the Toxic Equivalency (TEQ) concept was developed as  a biomarker for exposure and risk. TEQs are the sum of congener-specific toxic equivalency factors (TEFs) multiplied by the concentration in a matrix, e.g. blood. TEF values are a composite quantitative value from a range of biomarkers that are congener and endpoint specific. Present human TEQs have been derived from oral administration experiments providing ‘intake’ TEFs. Regulatory authorities frequently use ‘intake’ TEQs for blood and tissues considering it a biomarker for exposure or effect. Experimental evidence shows that using ‘uptake’ TEQs as ‘systemic’ biomarkers may lead to misinterpretation of risks. Therefore, development and validation of ‘systemic’ TEFs and TEQs as biomarkers is necessary. Major objectives of SYSTEQ are: i) establish ‘systemic’ TEFs and TEQs, ii) identify novel quantifiable biomarkers with newest molecular methods, e.g. genetic fingerprinting profiles, iii) extra focus on effects in peripheral lymphocytes as biomarkers, iv) identify differences between humans and experimental species. The ‘systemic’ TEFs and TEQs from SYSTEQ will be used in conjunction with results of the completed EU PCBRISK project, in which two populations from Slovakia with very different exposure were studied. Individual blood levels and different biomarkers are already available. Results of SYSTEQ are
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nature-inspired control of turbulent flows' (NiCoFlow).

assistant: **Innovation**

Many aspects of the animal flight still remain unexplored, despite the enormous possibilities they offer to improve the current aerospace technology.  One such aspect that received least attention of the scientists is the following: the wing surfaces of the flying animals are coated with hairs, feathers and other filamentous structures. These self-adaptive hairy layers strongly influence the flow field characteristics, and it has been reported that such coatings may be used to control the laminar-turbulent transition as well as turbulence in order to achieve energy efficient flight. The objectives of the NiCoFlow project are: (1) to devise the essential mathematical and computational framework to study the flow around objects with surface-mounted self-adaptive hairs, and (2) to elucidate the fundamental fluid dynamic mechanisms through which the surface coatings can enable new flow control strategies. In this work, a homogenized poro-elastic continuum models will be used to describe the flow through the hairy layers. Moreover, a computational approach to simulate two-way coupling between such homogenized continuum models and the surrounding fluid flow will be developed.. This approach will be thoroughly validated by simulating fluid flow over a flat plate attached with surface-mounted flexible hairs and comparing the numerical results against existing experimental data. The validated model will be used to perform direct numerical simulations of transitional and turbulent flows to reveal the detailed flow characteristics, and shed light on how these self-adaptive hairy features may delay the transition to turbulence and reduce the turbulent skin-friction. A potential passive control technique, relying on these nature-inspired hairy coatings, will have a large industrial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Development of delignified nanocellulose based gas transfer scaffold membrane for artificial lung applications.'.

assistant: **Innovation**

Lung disease is the third biggest cause of deaths globally. For the irreversible and terminal lung disease patients, lung transplantation is the only long-term therapy. Due to the unavailability the suitable donors, there is not only a minimum of 18 months of wait on the organ donation. Patients who eventually secure a lung transplant have less than 20% chance of recovery due to ‘poor organ function’. Therefore, there is not only a great need for an artificial lung as a permanent replacement organ but also as a bridge to transplantation. Existing artificial lung devices fail to mimic the flow gas exchange properties of a human lung and suffer from low biocompatibility, leading to undesired blood coagulation and hemolysis which limits their applicability to up to 30 days. The complexity and risk associated with current artificial lung technologies mean that they are not offered as long-term lung replacements or as a suitable bridge to transplantation.Through this 36 months EIC pathfinder project, the consortium led by Smart Reactors Ireland, aims to develop the world’s first biobased nanomaterial ‘nanocellulose’ to manufacture an artificial lung device used as a bridge to lung transplantation. The consortium will develop an initial proof of concept nanocellulose device to demonstrate gas transfer and initial hemocompatibility in blood. The proposed approach is expected to have two benefits, the first is that blood flow can occur in laminar flow conditions reducing haemolysis and damage to the blood. Secondly, nanocellulose, has the potential to be endothelialized which would allow for long term gas exchange without the need forsystemic anticoagulants.


**Keywords:** Artifiical Lung, Lung Disease, Oxygenator, Lung Transplant, Wearable Portable Lung
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator'.

assistant: **Innovation**

This proposal seeks to solve the high-resolution X-ray crystal structure of full-length Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), an anion channel which regulates chloride ion concentration at the lumen-exposed surface of epithelial cells. Mutations of the CFTR gene cause cystic fibrosis (CF), a lethal disease which results in bowel obstruction, lung disease and premature death. CFTR is an ATPase and a member of the ATP-Binding Cassette (ABC) transporter family of proteins which has an allosteric Regulatory (R) domain not found in other ABC transporters. From the structure of CFTR, its mode of action will be revealed, focusing on the two sites of ATP hydrolysis and key residues for channel gating. CFTR will be crystallized alone and in the presence of the pharmacological agent Kalydeco, a small molecule from Vertex Pharmaceuticals that is used for the treatment of CF and reduces CF symptoms. The initial high-resolution X-ray crystal structure is a foundation from which personalized drug design work can begin. Therefore, the Kalydeco-CFTR complex structure will be used for ligand optimization of Kalydeco, an iterative process which will improve Kalydeco’s specificity and pharmacokinetics. The latest technology, including in meso in situ serial crystallography and X-ray free electron lasers for serial femtosecond crystallography will be used as well as traditional synchrotron X-ray sources. These Actions use an interdisciplinary mix of crystallography, chemistry, biochemistry, biophysics and computational structural determination programs. The work will take place in Ireland in the lab of Dr. Martin Caffrey at Trinity College Dublin, a distinguished researcher in the field of membrane structural and functional biology. The prestigious Marie Skłodowska-Cu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Virtual amusement park' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Main Objective The main objective of project VPARK is to extend the existing VLNET Shared Virtual Environment system and to create a Virtual Amusement Park by integrating several applications on the platform. The Virtual Amusement Park will be developed as a major infrastructure to be used at a Pan-European level offering users the possibility to incorporate their own applications in the future. Technical Approach Our work will focus on the following issues:  -Extension of VLNET to provide a Networked Virtual Environment Software.  -Development of an attraction builder software.  -Development of four key attractions. The Core System Architecture will be modular, flexible and open. The internal modules, forming the core of the system, will provide basic functionalities at a relatively low level: visual data base management, animation of virtual humans, rendering, networking. A set of shared memory interfaces will allow external modules to exploit the functionalities provided by the core system. The current VLNET system supports a networked virtual environment that allows multiple users to interact with each other and their surroundings in real time. The users are represented by 3D virtual human actors with realistic appearances and articulations. In addition to user-guided agents, the environment can also include fully autonomous human agents. VLNET incorporates different media: sound, 3D models, facial interaction, textures mapped on 3D objects and real-time movies. The system will be extended in several ways:  -A more advanced network structure will be implemented, allowing better scalability in terms of supported number of users.  -New basic functions will be integrated. System's core and interfaces will be extended to support more multimedia objects: generalized imag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Coordinating cell differentiation and morphogenesis in a migrating tissue'.

assistant: **Innovation**

The formation of many organs involves the migration of cells in groups of different size and shape. Interestingly, these collective movements are also involved in metastatic processes in a variety of cancers. Yet how cells coordinate their behavior with that of their neighbors within moving groups is poorly understood. We use the posterior lateral line (pLL) of the Zebrafish as a model system to investigate how cell shape changes, differentiation, and directed tissue migration are functionally coupled during organ formation. During the second day of development of the zebrafish embryo, a group of about 100 cells, the pLL primordium (pLLP) migrate on both sides of the fish. As they migrate, subgroups of cells at the back assemble into rosette-like assemblies, the proneuromasts, that are progressively deposited behind and differentiate into the mechanosensory organs of the lateral line. Zebrafish embryos present the enormous advantage of being transparent at the beginning of their development. This, combined to superficial migration of the pLLP just under the skin makes this tissue an ideally suited model system for imaging complex morphogenetic movements in vivo. We have recently shown that the cellular rosettes are apically constricted epithelial clusters, radially organized around an fgf ligand-expressing cell. We further demonstrated that the FGF signaling pathway is required for cells to assemble into rosettes, and that in turn rosettes formation is a prerequisite for coordinated migration of the primordium. In order to understand how FGF signals drive cellular rosettes assembly, we will combine live cell imaging to genetics, mosaic analysis, pharmacological treatments and mathematical modeling to: (i) dissect the intracellular cascade downstream of Fgf (ii) perturb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Integrating genomics, epidemiology and evolution to accelerate tuberculosis eradication'.

assistant: **Innovation**

When the scale of the tuberculosis (TB) epidemic was highlighted by its declaration as a ""Global Emergency"" by WHO in 1993, it was envisaged that the efficient use of existing tools would result in a progressive decline towards eradication. This has not occurred. At the current pace of decline in TB incidence the Millennium objective to eradicate it by 2050 will not be met. Predictions of epidemiological models were inaccurate and current control programs and technologies have shown their limitations to control the transmission of the disease. To overcome these limitations we need a technological, methodological and conceptual leap forward that can reveal the unknowns of TB epidemiology. I propose whole genome sequencing (WGS) as the technology that can mediate this advance. While WGS has been applied mostly to retrospective datasets I propose to use it in prospective samples from a low-burden region at a population scale. Genome information will fill the gap between epidemiology and evolution to have a direct impact on public health. This will allow to develop innovative methodologies to describe transmission at an unprecedented resolution and as a consequence to differentiate among risks factors associated to the bacteria, the host, the environment and their interactions. Elucidation of these factors will lead to better models used to design new strategies and accelerate global TB eradication. In addition, I will show how the real-time integration of data in public eHealth systems combined with in situ interventions will accelerate TB eradication. The strength of the project resides in its multidisciplinary approach to TB epidemiology that will provide answers to yet-out-of-reach questions. It will lead to improving health status at the local level as well as to epi