RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Comparative INsect CHRONobiology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Chronobiology is the study of biological rhythms. The best understood cycles are those with circadian 24 hour periods that modulate the temporal dynamics of physiology and behaviour of all higher organisms.  Four model organisms have been widely used to study the underlying molecular biology of endogenous circadian clocks, Cyanobacteria, the fungus Neurospora, the fruitfly Drosophila, and the mouse. Insect clocks, both circadian and seasonal, are vital for adaptation to the environment and recent global patterns of climate change mean that insect pests and vectors of disease are expanding their ranges into Europe. Consequently there is an urgent need to study the circadian clocks of these insects and how they synchronise to the environment. CINCHRON will create an integrated European centre of excellence for the research training of ESRs in the emerging multidisciplinary field of Comparative INsect CHRONobiology. CINCHRON will bring together molecular neurogeneticists working predominantly with Drosophila, and comparative biologists who study circadian and seasonal clocks of non-model insects of economic importance. These researchers have different approaches so we will harness their different skills for mutual benefit via the integrated training of their ESRs in association with industrial partners. This will be done by high level interactions between university and industry, as well as interactions among laboratories with different areas of expertise, thereby connecting the different sectors (academic and commercial) as well as different disciplines. The goal is to seed-corn the next generation of researchers with highly trained, flexible workers in cutting edge technological methods and complementary generic skills that will support European academic, academic-relate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Obtaining atomically resolved structural information on individual bio molecules using electron holography'.

assistant: **Innovation**

The objective of this project is to develop a technology to determine the structure of individual biological macromolecules at atomic resolution. This would open up new areas of science and technology since the majority of proteins would then be accessible to direct structure determination at an accuracy allowing drug design. The technology is based on low energy electron point source microscopy, which is highly novel. Holography with low energy electrons does not employ lenses and thus does not suffer from lens aberration. In addition, it provides high contrast images and does not cause significant radiation damage. The structural information is contained in a hologram, which contains all information of the object wave. Phase and amplitude of the object wave are recorded and allow for a complete mathematical reconstruction of the original object. Although this project is high risk because of the ambitious nature of the objective, we plan to accomplish it in three years. We will proceed by solving the following tangible objectives: Demonstrate that it is possible to suspend a single molecule in the path of a low energy electron beam (e.g. a coherent electron wave) without it undergoing a significant conformational change, obtain high contrast holograms before significant beam damage occurs and reconstruct the molecule from the hologram. This project is highly interdisciplinary because finding solutions to these challenges requires specialized knowledge in diverse areas of science. Leaders in their fields of endeavour from across Europe have formed a consortium to bring together a critical mass of expertise needed for this project. If successful, this project would have an impact well beyond it's objective. It would change the culture of life sciences as it would bring a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Open Rotor Engines Advanced Technologies for rotor blade pitch change mechanism', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Pitch Change Mechanism Conceptual and Preliminary Design Activities. A principal contributor to affordable and sustainable public air transportation will be the introduction of more fuel-efficient propulsion systems, one of which is the Open Rotor Engine concept. Unlike turbofans, open rotors must vary blade pitch to accommodate power and aircraft speed range, so a key element to the viability of the concept is the actuation and control of the blade pitch via the Pitch Change Mechanism (PCM). GE Aviation Systems Ltd (trading as Dowty Propellers) is engaged in specifying requirements and concept evaluation for PCMs for direct-drive pusher open rotors in the EU 7th Framework DREAM SP3 work package 3.1. Dowty Propellers has also participated in similar studies with GE Aviation Engine division to assess the viability of a number of PCM control and actuation concepts. GE Aviation proposes to build on this background to support the SAGE 2 engine PCM. The work packages proposed via this application will focus on developing the critical technologies associated with the selected actuation system concept. The proposal describes the activity supporting functional, architectural, failure mode, mass, and performance analyses, the creation of a preliminary bill of material and definition of system performance and safety verification. The deliverables from the programme will be the definition of the preferred PCM concept with 3D geometry, performance, functional, safety and reliability assessments, interface definition and power plant control system integration architecture proposal. The work packages will be closely aligned to the engine demonstrator requirements, in preparation for the launch of demonstration hardware.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Application support services for distributed mobilemultimedia' in the context of a Fourth Framework call.

assistant: **Objectives**

Today, mobile networks provide only a small range of simple services, leaving multimedia out of reach. In stark contrast, the volume and richness of information services on fixed networks is growing at an accelerated pace. In the near future, wherever they are, people will want to use multimedia information services, whether global or local to a particular area, on fixed or mobile networks. Many different types of computers, including laptops, palmtops, personal assistants, but also mobile telephones, will help users to access a variety of networks and services.OnTheMove addresses this issue by defining a Mobile Application Support Environment (MASE) providing support for applications running on mobile devices. This architecture includes a mobile application programming interface, Mobile API, that hides the heterogeneity of underlying networks and user equipment as well as the mobility related functions as such. The OnTheMove architecture is based on the latest research and OnTheMove is the only project in ACTS demonstrating UMTS-based middleware for client server systems.During the second year of the project we succeeded in defining the MASE middleware architecture and its services offered to mobile-aware" applications. These include among others location awareness, messaging and multiparty services, cost control, security, disconnected operation, terminal adaptation, profile management and support for distributed environments. The implementation of the first version of the MASE will be finished within the second project year.Our first experiment 0 began in June 1996 and included about 40 external users. The application designed and implemented for this experiment included stock portfolio information, news telegrams, travel information and access to news magazines as w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Supporting the future of the NEM European Technology Platform' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The NEM European Technology Platform is well on the way to achieving the major objectives defined at the creation of the platform, five years ago. It has helped to change the environment, encouraging the emergence of a strong European awareness of the Future Media Internet issues, supporting the creation of various forums concerned with that topic, and leading the development of a possible PPP on that subject.<br/>In that context, a new era opens now for the platform, which will have to invent its future, without losing the benefit of the work already performed.<br/>FutureNEM will assist the NEM ETP to realize that ambition. As a Support Action, it will stimulate the activities that industry cannot perform by itself. It includes the necessary tasks to meet the following objectives:To keep a high visibility of the NEM Initiative thanks to publication of the NEMLetter and new communication tools where needed,To promote the contribution of NEM to the various Future Internet coordination instruments in order to keep a high profile of content related matters in the Future (Media) InternetTo support the organisation of the Open NEM discussion Forum that will advise the platform on various issuesTo prepare the definition of the future of the NEM Initiative, NEM2.0,To assist the production of relevant positions on research directions and to organise the emergence of NEM public positions,To support the organisation of the NEM Summit,To facilitate liaison with other R&D communities around the world in order to promote the NEM messages,To promote NEM to new communities, especially Content producers,To develop the presence of NEM at the national/local level in order to involve more SME actors in its works.<br/>The FutureNEM consortium consists of key actors of the NEM plat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New generation of chimeric TLR2-NOD agonist compounds for vaccine adjuvants', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

New vaccine modalities need to be developed that can activate more potently the immune system, in this regard, adjuvants augment adaptive immune responses and can improve vaccine performance. Aluminium salt (alum) is the most commonly used adjuvant for human vaccination. However, it drives primarily TH2-effector responses and is not effective for vaccines that target mucosal surfaces. Thus, safe and potent adjuvants need to be developed that can increase and direct vaccine-specific immunity. Recent advances in our understanding of innate immune responses are providing opportunities to design better adjuvants. The innate immune system senses microbes through pattern-recognition receptors (PPRs), which include the Toll-like receptors (TLRs), and intracellular NOD-like receptors (NLRs) and C-type lectin-like (CTLs) receptors that are expressed by immune cells. Activation of these receptors leads to the production of cytokines that provide early defences during infection. Cytokines also regulate adaptive immunity by controlling the quantity and quality of B and T cell activation, which in turn results in protective immune responses to pathogens. Pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharides, lipopeptides, and peptidoglycan fragments can activate PPRs and are attractive compounds for the development of new adjuvant. Although during microbial infection many different PRRs are activated, almost all adjuvants that are being developed rely on the stimulation of a single PRR. In this project, we propose that compound adjuvants derived by the covalent linking of two PAMPs (fusion PAMPs), for example, TLR2 and NOD agonists, will ensure that immune cells are being exposed to both, resulting in efficient cross talk of signal transduction pathways and in s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Eco-friendly and bioinspired protein-based synthesis of magnetic nanomaterials for advanced cancer theranostics'.

assistant: **Innovation**

The key goals of “ProteNano-MAG” are: (a) the training of a talented researcher, Dr. Lourdes Marcano, in the fast-growing field of science, technology and industrial applications of nanomedicine, where the host and partner institutions have critical knowledge and expertise; and, (b) the design, development and optimisation of eco-friendly synthesis routes using bioinspired simplified engineered proteins as templates for the preparation of magnetic nanoparticles for effective diagnosis and therapeutic intervention in cancer treatment. The interdisciplinary training program includes protein engineering, preparation of magnetic nanomaterials, characterization including sophisticated synchrotron-related techniques, in-vitro studies, magnetic resonance imaging and implementation for hyperthermia applications. The fellow is a talented researcher who has gained much expertise in biological synthesis mediated by magnetotactic bacteria (natural systems which are inspiration to “ProteNano-MAG”) and structural and magnetic characterization of single-domain magnetic nanoparticles during her undergraduate and postgraduate career. To further boost her career, she needs to gain expertise in alternative routes for the preparation of magnetic nanomaterials, design and characterization of recombinant simplified protein systems and state-of-the-art techniques such as space-resolved X-ray fluorescence and absorption spectroscopies, fields in which the CIC biomaGUNE and the two secondment’ co-hosts, the ESRF and the Universität Bayreuth, have a world-recognised expertise. Additionally, through the six-month placement at Resonant Circuits Ltd., the fellow will gain additional high-level training in magnetic hyperthermia for the medical/industrial application of the prepared magnetic nanopart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The B cell memory program: cell fate determinants and functional diversity of B cell subsets'.

assistant: **Innovation**

B cells are responsible for the humoral arm of the immune response and most successfulvaccines in humans are antibody-based. Depending on the pathogen, specific B cell subsets aremobilized and a variety of innate, intermediate or adaptive responses are produced. In somecases these responses generate memory in anticipation of a re-encounter with the same pathogen.B cells can also present antigens to T cells, and enhance or suppress immune responses,depending in which T cell context they are primed.The present project aims to describe new innate-like and memory B cell subsets and tounravel the molecular switch allowing the differentiation and the long-term maintenanceinto the memory program. This will be done by combining approaches in both humans andmice, in order to reveal the analogies and the differences between these two immunesystems.Our main specific aims are 1) to establish a reporter cell line that, by complementation with acDNA library from human centrocytes and memory B cells, should allow the identification of amaster gene able to trigger the memory program 2) to compare various antigenic andendogenous stimuli in terms of formation of various innate-like and memory subsets, using amouse model that, by marking irreversibly B cells during an immune response, has allowed us toreveal new layers of B-cell memory 3) to study the endogenous and exogenous signals thatsupport the development of marginal zone B cells in humans 4) to unravel the genes that governlong-term B cell memory, by isolating anti-vaccinia virus long-lived human memory B cells. Thegeneral ambition is to provide new insights into the complexity of the B cell compartment thatshould allow the improvement of B-cell targeted vaccination strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimisation of anaerobic granular sludge reactors : speciation, bioavailability and dosing strategies of trace metals' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The effects of the metals Co and Ni on the treatment performance of a continuously operated methanogenic UASB reactor fed with either methanol or glucose as the substrate will be investigated. Addition of trace metals does not guarantee that these are bioavailability, as ions must be in a soluble state to be bioavailable. The contracted research fellow will carry out a work program to characterize the bioavailable metal fractions in methanogenic granular sludge from a Up flow Anaerobic Sludge Bed (UASB) reactor treating a wastewater containing a mixture of heavy metals. Dissolved Ni and Co in the sludge could be operationally discriminated into labile (comprising the free ion, inorganic complexes and weak organic complexes) and total (comprising additionally strong organic complexes and colloidal forms) species by adsorptive cathodic stripping voltammetry (AdCSV) using dimethyl glyoxime (DMG) as the complexing ligand. The applicant will develop and optimize the AdCSV protocols to determine Ni and Co species. These data will be compared with the theoretical metal concentration, as predicted by speciation model (MINEQL+). The bio film itself will be analyzed using a sequential metal extraction to distinguish the exchangeable, adsorbed, organically bound, carbonate and sulfide residual fractions. Thus, a targeted dosing of heavy metals can lead to an optimization of the process performance by studying bioreactor performance which would be correlated with the bioavailability of the metals. According to applicant knowledge, he is very interested in studying metals bioavailability and mobility in UASB reactors. As he is also very interested to get international experience, working in a dynamic, multidisciplinary and international research team will be very helpful. This train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Comparative Phylogeography of a Megadiverse Fauna across the Mediterranean' (CO-PHY-MED) under Horizon 2020.

assistant: **Objectives**

The aim of this project is to investigate the mechanisms and processes that drive divergence and speciation, and shape the biogeographical history of organisms. Using the Mediterranean, a natural laboratory for phylogeographic investigations, we propose a novel large-scale approach in comparative phylogeography: a time-saving and cost-efficient one that includes multiple lines of evidence in a single analysis and exploits modern Next Generation Sequencing methods and advances in phylogenomics. We will (1) collect genomic data for co-distributed species of an entire vertebrate order (squamate reptiles) applying sequence-capture protocols, (2) reconstruct a time-calibrated, fully resolved phylogenetic tree merging between- and within-species relations, (3) compare biogeographical and speciation patterns and (4) identify the major barriers that influenced the formation and evolution of biodiversity. Tackling this innovative and challenging project and hosted in institutions of international reputation by leading experts in their field, will contribute to his professional academic development and put him at the forefront of his field. The applicant is an early-career promising scientist and the participating institutes and research-groups have the qualifications and complementarity, regarding infrastructure, research experience, capacity to manage grants and train researchers, for the successful outcome of the research and training aspects of the project. The approaches and results of the project will become a part of the state-of-the-art of future studies and promote EU excellence in evolutionary biology and phylogenomics, likely to be in great demand in the near future. Results will be announced in prestigious international conferences and published in high ranked journal