RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'KNOWLEDGE-BASED SYSTEM FOR CONSISTENCY IN BIBLIOGRAPHIC DATABASES' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

KSYSERROR is to develop a program for improving the quality control of bibliographic database records via a knowledge-based error-detection system connected to library networks using client/server architecture. Whilst offering many advantages, networked sharing of records can lead to recurrent copying of incorrect records. The knowledge-based system will be designed to receive records and classify them as correct or incorrect on the basis of errors or inconsistencies likely to affect quality. It will make a key contribution to library information services, and is planned for marketing to libraries making heavy use of networked bibliographic record exchanges.Technical approach: The demonstrator will be based on the following technical criteria:- application of a knowledge-based system designed to detect errors in MARC catalogues;- compilation of lists of various types indicating the types of corrective action required (mechanical errors, format errors, etc.);- integration of client-server technology;- possibility of connection to any network.The outcome will be two types of file, one containing records which are deemed to be correct, the other containing records which apparently require correction. Key issues:The need for enhanced quality control of bibliographic records is clearly felt by library managers. If a library receives large volumes of information over the network, considerable resources often need to be devoted to cleaning up the new files.The project will need to develop facilities which will significantly reduce the amount of time required for human correction by automating the detection process and, as far as possible, categorising the types of error detected. Impact and expected results: Currently there are no products available in the European library sec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structural and functional insight into the biosynthesis of endogenous lipidic messengers by the N-Acyl Phosphatidylethanolamine Phospholipase D (NAPE-PLD)' (NAPE-PLD).

assistant: **Concept**

Imbalances of human major lipid signaling pathways contribute to progression in inflammation, neurodegenerative and metabolic diseases. Among lipidic messengers, the family of bioactive N-Acylethanolamines (NAEs) is agonist at cannabinoid and nuclear α-type peroxisome proliferator-activated receptors. The ability of NAEs and their metabolic enzymes to modulate neurotransmission and a variety of pathophysiological processes, including inflammation, appetite, pain and mood, provides unique chances for drug discovery. Upon stimulation, bioactive NAEs are generated from cell membranes in a two-step pathway, which involves an N-acyltransferase and an N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). NAEs bearing saturated and monounsaturated long acyl chains are significantly decreased in NAPE-PLD(-/-) mice suggesting this enzymes as  key regulators of the NAE-mediated signaling potential. Very little is known about the molecular architecture of NAPE-PLD and the specific functional role of its N- and C-terminal domains. If given a chance, I will study domain trafficking in activated cells and to solve the X-ray structure of this membrane-bound protein. I will characterize the thermodynamics and kinetics of enzyme interactions, which are essential in understanding how NAPE-PLD synthesizes NEAs and controls their cellular level. Findings will be used for a rational approach in the design of potent and selective NAPE-PLD ligands, which can be exploited pharmacologically to modulate the level of NAEs in inflammation, pain, and neurodegenerative disorders. These aims are a common goal of cell biology, structural biology, pharmacology, and medicinal chemistry, which could give an invaluable blueprint for the design of selective inhibitors, thus strongly impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reducing networking gaps between Rīga Stradiņš University (RSU) and internationally - leading counterparts in viral infection-induced autoimmunity research' (RSU), addressing dissemination and exploitation.

assistant: **Impact**

The specific challenge of VirA Twinning project is to enhance networking activities between the Riga Stradins University (RSU) located in Latvia as a Widening country and internationally-leading counterparts at EU level, in the field of autoimmunity research. RSU is an institution that has proven itself over several decades on a local and regional level as an important island of research excellence in viral infection-induced autoimmunity research. Further raising the research excellence requires widening the network and establishing closer cooperation with global leaders in science, sharpening the institutional profile of RSU. Project aims at strengthening the close scientific cooperation with counterparts: in Italy - University of Ferrara, in Germany - Ulm University, and in Israel - Tel-Aviv University. The partner universities are the excellence centres (world leaders) that are forerunners in immunology, virology, morphology and clinical data management and modelling, and are capable of inspiring positive change in the research field and significantly influence future developments at RSU via joint activities.Systemic autoimmune diseases (SAD) are a significant cause of morbidity and mortality worldwide, creating a challenge for researchers and clinicians to find evidence-based solutions for SAD diagnostics, treatment and prevention. Due to the complexity of autoimmune disease research, which requires multidisciplinary approaches, a problem is insufficient research capacity at low-performing EU Member State research institutions. Research capacity, able to deliver precise and early diagnostic is of high importance to move towards the development of methods for personalized medicine and better understanding of triggers and mechanisms in autoimmunity, leading to better
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Easy-to-use diagnostic tool for the killing efficacy of antibiotics on clinical isolates' (SurviDisk) targeting Horizon 2020.

assistant: **Abstract**

This proposal aims to develop a low-cost diagnostic tool (SurviDisk) that can evaluate the killing efficacy of antibiotic treatments on bacterial strains isolated from patients. Current methods, such as the disk diffusion assay, only evaluate the ability of antibiotics to arrest the growth of bacteria. The size of the inhibition zone in the disk diffusion assay indicates the Minimum Inhibitory Concentration (MIC) i.e. the resistance level of the strain, but cannot distinguish between a cidal drug from an antibiotic that only stops the growth of bacteria without killing.  It is today recognized that antibiotics that are able to kill bacteria are crucial for hard to treat infections that persist for many days despite treatment.  However, bacterial strains can evolve to become tolerant and avoid killing by antibiotics. This tolerance is distinct from resistance, and only allows the strains to survive under antibiotic treatments but does not increase their MIC. The enhanced survival of these strains under antibiotics is not detected in the current antibiotic susceptibility tests done in hospitals. In the parent ERC-CoG grant, we have recently shown that measuring the survival of clinical strains isolated from life-threatening bloodstream infections  enables to choose better treatments. Based on these results, we propose to develop a single disk easy-to-use low-cost assay for a semi-quantitative measurement of survival of bacteria under antibiotics, the Survidisk. We will develop the Survidisk prototype and evaluate its efficacy at predicting the treatment outcome on a retrospect analysis of a collection of clinical strains. Contacts for the production and commercialization by companies selling disk diffusion assays will be developed. We expect that the routine use of the Su
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photoreception in Drosophila larvae: Information coding in a simple neuronal circuit' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

How does the neuronal network of the brain mediate its function? This fundamental question in biology is still a puzzle, despite decades of intensive work. A seemingly unsolvable obstacle when studying the brain is its enormous complexity.A powerful approach to understand our brain uses “simple” brains of animal models, in which one can genetically identify and manipulate neurons. The brain of the fruit fly Drosophila melanogaster is widely used as an impacting model system to study how the brain functions with the advantage that the fly brain is much simpler compared to the mammalian brain. Even another one order of magnitude simpler is the brain of the Drosophila larva consisting of an estimated 10’000 neurons. We use the Drosophila larva as an excellent model to genetically dissect a comparably simple visual system. The eye of the larva consists only of two types of photoreceptor neurons: four blue-sensitive cells expressing Rhodopsin5 (Rh5) and eight green-sensitive cells expressing Rhodpsin6 (Rh6). The photoreceptors transmit the information to a small set of target neurons in the larval optic neuropil (LON). We found that only 12-15 brain interneurons connect to the LON, which can be classified in four different groups, according to location and neurotransmitter they use.The goal of this project is to dissect neuronal circuits of visual information processing: from mapping synaptic connections in the circuit to the behavioural impact of neurons. Preliminary results of my laboratory and a “step-by-step strategy” support the feasibility to reach these ambitious goals (Sprecher et al., 2011; Von Essen et al., 2011, Keene et al., 2011).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Evaluation of availability to biota for organic compounds ubiquitous in soils and sediments', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Contamination of soils and sediments by organic chemicals is a major threat to the environmental quality of freshwater and groundwater resources. At present, assessment of the risks of soil and sediment contamination is based on the assumption of bulk organic carbon-based equilibrium partitioning. However, it is generally accepted in scientific circles that this assumption is inappropriate and can lead to an overestimation of the risks of soil and sediment contamination. This project will investigate the mechanistic basis for the formation of different sorbed fractions of contaminants in soils and sediments and the bioavailability of these fractions. Methods will be developed to easily determine bioavailable fractions of contaminants in relation to their sorption kinetics. These results will be exploited to develop protocols for the risk assessment of sorbed contaminants in soils and sediments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Multi object spectrometer with an array of superconducting integrated circuits'.

assistant: **Innovation**

Recent sub-millimeter instruments on the Herschel Space Observatory, operational from 2009-2013, have discovered thousands of sub-millimeter galaxies, whose combined emission forms the cosmic infrared background. A major challenge is to measure their distance, or age, by determining their redshifts, which also has to be based on the sub-millimeter signals (because they do not have an optical counterpart).  I propose to develop a new redshift survey instrument, using recent progress in superconducting nanotechnology, which can spectrally resolve a large fraction of the cosmic infrared background from the ground. The instrument is a Multi-Object Spectrometer with an Array of superconducting Integrated Circuits. It consists of a 3D integrated field spectrograph with a 2D array of 25 pixels sparsely filling the re-imaged focal plane of the observatory. For each pixel the instrument measures the radiation spectrum in a 325-905 GHz window with a resolution R=F/δF=500. Additionally the beam of each pixel can be steered electrically to lock onto an individual astronomical object. This allows fast, high accuracy redshift determination of 25 objects simultaneously by measuring the frequency shift of the CII and CO lines. I will develop the instrument, build it, install it on the 10 m Japanese ASTE observatory in Chile and facilitate its use.MOSAIC will be fully based on novel superconducting circuits: a broad-band antenna with electrical beam steering and an on-chip spectrometer, combined on a single chip. The design of the instrument is based on recent developments in superconducting nanotechnology, for signals in the GHz to THz range, in which I am currently playing a leading role. The instrument will be developed with a team of experts in the fields of antennas, spectrometer a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sources, transport, and degradation of permafrost-derived organic carbon in a warming Arctic: the Siberian Shelf""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Among the mechanisms that could move significant quantities of green house gases into the atmosphere within this century, climate scientists are particularly concerned about the carbon (C) locked in permanently frozen Arctic ground that is now being released because of warming temperatures. Given the extent of this mega-pool of C (~1,400 Gt of C) susceptible to climate-induce changes compared to the atmospheric reservoir (~750 Gt of C), the potential release of this stock into the atmosphere due to thawing is considered a serious risk for the future climate. Recent studies suggest that a significant fraction of previously frozen soil will be re-located along the Arctic shelf. Indeed there are ample of evidence indicating that land-to-ocean fluxes of organic carbon (OC) along the Arctic coasts are changing because of thermal collapse of coastal permafrost and increase of the river runoff. However, the fate of this material once re-introduced in the marine carbon cycle is poorly constrained.With this project we propose to address this critical knowledge gap by analyzing the composition and physical properties of surface sediments from the Siberian Shelf. Our overarching objective is to develop and test a sensitive proxy of land-derived OC degradation in a system that will experience a massive supply of terrigenous material in the near future. The extent of degradation will be assessed using mineral surface-normalized concentrations of terrigenous OC. This latter will be characterized at molecular level using a suite of terrigenous biomarkers including lignin phenols, cutin-derived products, and high molecular weight compounds (n-alkanols, n-alkanoic acids and n-alkanes). The degree of soil-OC degradation will be assesses as a function of the depletion of the terrigenous b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gene-Independent Combination Therapy for Rod-Cone Dystrophy', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Rod-cone dystrophies are inherited retinal diseases whose clinical course begin with the degeneration of rod photoreceptors and evolve with the progressive loss of cones that, in turn, leads to complete blindness. These diseases affect 1:2500 individuals worldwide with many underlying gene defects. Although gene replacement therapy has been very successful in treating inherited retinal degenerations in the clinic, with one FDA approved product on the market and over 30 clinical trials, it is costly and time consuming to develop a gene replacement therapy for each mutation. Moreover, gene replacement can only be helpful if the underlying mutation is known and recessive.Despite the genetic heterogeneity of these diseases as well as their inherent complexity, all rod-cone dystrophies converge on a common phenotype of rod cell loss, followed by cone cell degeneration first in the periphery and then in the fovea, leading to complete blindness. A gene therapy approach aiming to counteract the symptoms of rod-cone dystrophy rather than the individual genetic causes has the potential to be helpful in the highest number of affected patients.In this action we propose to develop a combination gene therapy to restore light sensitivity in mouse models of rod-cone dystrophies. AAV-mediated expression of optogenetic channels in cone photoreceptors will restore light sensitivity and maintain downstream retinal circuitry processing. The optogenetic therapy will be combined with the AAV-mediated delivery of rod derived cone viability factor (RdCVF), a factor normally secreted by rods to promote cone survival, lost in rod-cone dystrophies; RdCVF expression in combination with optogenetic channel expression will promote survival of newly lightsensitive cones. Furthermore, this action propo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of insulin signalling factors that delay age-related memory impairment' (AGE-MEMORY).

assistant: **Concept**

Elucidation of the biological mechanisms that govern ageing can facilitate the discovery of evolutionarily conserved factors, which denominate physiological deterioration in humans. Here we will study the effect of insulin/insulin like growth factor signalling (IIS), shown to delay ageing in several organisms, on age-related memory impairment (AMI). We will use both C. elegans and Drosophila as experimental platforms, to test evolutionarily conservation of findings. Longevity combined with memory experiments will be applied in several IIS mutants. We will dissect IIS to find putative mediators of IIS effects on cognitive function. To identify relative mechanisms we will measure activity of known AMI regulators in IIS mutants. Depending on our results, our study will expand on transcription profiling worms and flies IIS mutants of different ages. Neuronal genes differentially affected by IIS will be further studied. We will use novel imaging techniques to characterize morphological changes that occur through ageing in the nervous system. This study is a first step to identify universal mechanisms that underlay cognitive function decline. Pharmacological manipulation of such mechanisms could delay AMI in humans.