RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Assessment of organotin compounds in the environment of Greece' (ENVIROTRACE) under Fourth Framework.

assistant: **Objectives**

Research on metal speciation techniques has recently become one of the fastest growing area of analytical chemistry. The tandem combination of instruments has opened up a new area of research. The so-called hyphenated techniques seem to be the methods of choice to achieve both the sensitivity and specificity requirements. This term denotes a combination of a separation technique, usually high performance liquid chromatography (HPLC) or gas chromatography (GC), and a metal-selective technique such as AAS or AES. The proposed project Assessment of Organotin Compounds in the Environment of Greece" deals with the setting up and further improvement of hyphenated techniques based on the coupling of HPLC with QFAAS, for the identification and determination of these compounds in complex environmental matrices. It combines two areas of scientific expertise representing the current state-of-art in the field: * Analytical methods based on HPLC-HG-QFAAS for organometallic compounds that can be converted into hydrides, such as organotin, organoselenium, organoarsenium etc. A direct, continuous, and on-line interface through the use of a post-column hydride generator to link up the HPLC and the AA furnace will be set up. The hydride generator interface has the advantage of isolating the analytes from the sample stream, thus avoinding any interferences due to the sample. The organometallic compounds are conveted into their hydrides by addition of NaBH4 and are drained to the gas-liquid separator. Then, the volatile hydrides produced are atomised in a flame-heatedquartz tube. In this design, the sensitivity of the detector increases by allowing the analyte to remain for a longer period in the optical path. * The improved and optimized methods will be applied for the determination of or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Understanding and harnessing natural variation in adaptability' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The rise of antimicrobial resistance is an urgent global threat to human health and global healthcare capacities. Despite ongoing efforts to develop new antimicrobial drugs, eventual adaptation is an inevitable corollary of evolution. Long-term solutions therefore require innovative approaches, including (1) learning to predict adaptation and (2) developing platforms to screen strategies against microbial adaptation.  The capacity of an organism to adapt to new environments, also described as adaptability, is a heritable trait that varies substantially between even closely related lineages. Dissecting the genetic basis and mechanisms driving variation in adaptability is the critical first step in achieving these long-term objectives.As an MCSA fellow, Dr Xanita Saayman will receive training from Dr Gianni Liti at the Institute for Research in Cancer and Ageing (IRCAN) and from Dr Jonas Warringer during a secondment to the University of Gothenburg. Throughout NAT-ADAPT, Dr Saayman will exploit an extensive collection of Saccharomyces cerevisiae isolates with unprecedented scales of phenotypic and genotypic diversity. Bridging interdisciplinary fields (e.g., population genetics, phenomics, genomics, genome engineering), NAT-ADAPT will identify and characterise genetic drivers of adaptability, harnessing this knowledge for two applications. First, NAT-ADAPT will model adaptation dynamics based on quantifiable genome properties, serving as an invaluable resource for predicting the emergence of antimicrobial resistance. Second, NAT-ADAPT will produce ‘hyper-evolver’ Saccharomyces cerevisiae strains. Such strains can serve as critical platforms with which to screen strategies against microbial adaptation, improving the efficacy of current antimicrobial solutions.


**Keywords
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The LPS-code: uncovering meta-level chemical structures that establish LPS as friend or foe', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The lipopolysaccharide endotoxins (LPSs) are ubiquitous microbial cell surface glycolipids of Gram-negative bacteria and are key molecular actors in the interaction with eukaryotic hosts. Traditionally, studies have focused on the role of LPS as dangerous and potent molecules with the ability to boost innate immunity in eukaryotes and cause sepsis in humans and severe pathologies in plants. In recent years, however, it has become clear that LPS is not always working as a microbial weapon. Indeed, LPS also covers the surface of symbiotic and beneficial bacteria. However, a precise chemical and molecular information on this duality remains elusive. Two central questions remain unsolved with the required chemical precision: i) which are the key features of the molecular interactions between LPSs and the host receptors; ii) how the subsequent signalling pathways lead to either pathogenicity or symbiosis in mammals and in plants. Indeed, despite the harmful image of LPS, disentangling these features of LPS chemistry could inspire new avenues for the employment of LPS and LPS-like molecules as a novel generation of therapeutics in medicine and agriculture.Thus, the key objective of LPS-CODE is to unravel the key features of the molecular interactions between LPS and the host receptors and decipher the subsequent signalling pathways in both animals and plants. This will be achieved by identifying the key microdomains within the LPS molecules that establish beneficial or detrimental interactions with the host, eventually driving elicitation or suppression of host innate immunity. LPS-CODE is grounded on (bio)-organic chemistry and chemical biology, with strong emphasis on glycan chemistry and structural glycosciences to decode the microbial language and thus decipher the chemic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Urban Development Explorations using Natural Experiments' (UDENE) targeting Horizon Europe.

assistant: **Abstract**

Urbanization is increasing globally, with almost all cities growing in population This growth is more prominent in Europe and North Africa, where 70% and 78% of people, respectively, live in cities. Climate change, inequalities and conflict drive huge populations to cities, in search of a better life. However, urban development is not generally guided by evidence-based informed decisions, especially in emerging countries. As a result, liveability in cities worsen. The UDENE Project aims to use large amounts of Earth Observation (EO) data from Copernicus satellites and local sources to support evidence-based decision making for urban development, especially in international partner countries. To support the UN Sustainable Development Goal 11 of making cities safe, resilient, and sustainable, the project will essentially create a virtual laboratory for urban planners and visionaries to test their development ideas. Multi-dimensional models of urban areas across time and across countries will be used to support urban planners in exploring natural occurrences of similar development ideas, concepts, or projects in similar urban areas (natural experiments). The wealth of EO data in fast accessible Data Cube format provides a great search space for exploring natural experiments, by exploiting greater value-add of causal analysis. Project outcomes will be embodied by an exploration tool for natural experiments and a match-making tool which will leverage the exploration tool by linking the existing EO product, process, or service offerings. Project activities include cooperations for data acquisition and partnership building that will be facilitated by Open (FSTP) Calls. We are confident that our evidence-based approach for urban development as powered by vast EO data will compl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Designing for Adaptability and evolutioN in System of systems Engineering'.

assistant: **Concept**

Systems of Systems consist of collections of (possibly independent, pre-existing, geographically distributed and following their own goals) constituent systems whose behaviours are coordinated to provide services and additional value with respect to their original intended operations. This kind of entities offer severe technical, management, and political challenges as witnessed by energy blackouts such as the one experienced by Italy in 2003 and the emergency management disaster in response to the hurricane Katrina in 2005. DANSE aims at developing new approaches to the design and management of the operation of SoS based on: advanced methodologies based on a new evolutionary, adaptive and iterative SoS life-cycle model; semantically sound models based on the notion of contracts; innovative architectures that provide the infrastructure to allow the dynamic affiliation of components so that the behaviour of the ensemble is not disturbed; novel supporting tools for analysis, simulation, and optimization; organized in an integrated environment.  DANSE will develop training material and classes that help advance the knowledge base of European industry and government to allow the creation of new services and to substantially improve existing ones to levels of efficiency that are unthinkable today. DANSE includes industrial representatives with focus on Aerospace and Land systems and Automotive, leading tools and framework provider in the system space and top European research institutes in system engineering. The partners have a deep interest in the outcome of the research and are eager to deploy them as soon as they become available. Three Test Cases – Air Traffic Management, Autonomous Ground Transport and Integrated Water Treatment and Supply-- which are real industrial p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Health-promoting cross-talk between intestinal microbiota and Humans' (CROSS-TALK).

assistant: **Concept**

The multi-partner initial training network entitled “Health-Promoting Cross-talk between Intestinal Microbiota and Humans (CROSS-TALK)” aims at: • Preparing qualified young professionals/researchers and future scientific leaders in the field of an emerging supra-discipline, the human microbiome metagenomics (which calls for new researcher curricula and fosters a dynamic scientific community) through a personal and adapted training program, • Answering key questions on the role of the host-gut microbiota cross-talk in the development and maintenance of a healthy gut. • Developing new concepts and trans-discipline training based on, the integrated scientific programme, laboratory exchanges and dedicated education proposed in CROSS-TALK In order to reach these objectives, CROSS-TALK establishes a collaborative research and training network of 10 network participants and 3 associated partners. This network gathers expertises in complementary disciplines (i.e. microbiology, immunology, cell biology [in-vitro] and molecular biology, in-vivo biology [animal models, humans], biochemistry, proteomics, transcriptomics) and participants from both the academic and private sectors with an excellent track record of collaborative research. The network also offers a complete range of theoretical, practical and complementary training as well as scientific workshops. The excellent scientific network of CROSS-TALK will work together with the young researchers to develop and implement effective training plans tailored to each individual’s requirements. Regular meetings, active networking, connections with other scientific projects in the field and with commercial participants will ensure the success of this project and give the recruited researchers an excellent opportunity to reach their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CO2VOLC: Quantifying the global volcanic CO2 cycle' (CO2VOLC).

assistant: **Innovation**

Global climate change induced by anthropogenic emissions of CO2 is currently a major issue facing humanity, but uncertainties in the magnitude and rate of climate change remain, and deterministic predictions are beyond our capacity. In this context, the study of how the geochemical carbon cycle established a relatively narrow band of variability in atmospheric CO2 concentrations over the last 400 ka is of great interest. However, large uncertainties in both weathering and volcanic CO2 fluxes prevent a truly quantitative assessment of this critical cycle. Measuring the global volcanic CO2 flux, GVFCO2, would allow us to better understand the likely impact large eruptions have had in Earth’s history, and constrain the natural vs. anthropogenic CO2 flux.We propose a truly innovative project to address head on the problem of determining GVFCO2. We will create new, compact instruments, utilising cutting-edge laser technologies, which will allow us to measure volcanic CO2, H2O, SO2 and HCl fluxes from aircraft. By flying below and through the volcanic plumes created by ~50 active volcanoes (~10% of all active volcanoes) of the Banda-Sunda arc in Indonesia, the majority of which have never been measured before, we will dramatically increase our understanding of GVFCO2 and geochemical cycles for all these species.Measuring the volcanic emissions from an entire subduction arc is an unprecedented experiment, providing insight into the slab and mantle heterogeneity and volatile mass balance. Perhaps the most important breakthrough that we will pursue will be the determination of the 37Cl/35Cl ratio from HCl emitted from each volcano. This ratio reflects the mantle/slab source proportion, and allows the input rate of volatiles to the mantle to be measured.The application of innovat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DNA Evidence and Technology Against Intruders' (DETAIN).

assistant: **Innovation**

Proposal Abstract Domestic burglary is one of the most costly and frequent crimes in Europe with the number of cases estimated to exceed 4 2 million per annum costing approximately 19,7bn. Current home alarm and security systems do not act as compelling deterrents for burglars. They provide little effective alert due to the high frequency of false alarms or adequate evidence for the apprehension and conviction of a criminal. Consequently there is the need for a home security system which accurately links an intruder to a specific burglary crime with irrefutable evidence and which can be subsequently used to identify and convict the criminal. Our idea is to develop a DNA based marker unique to each protected home which can be sprayed on to an intruder and which will remain attached to the intruders hair skin and clothes for a sufficient length of time until the criminal to be apprehended. Detection and subsequent forensic analysis of the DNA marker will provide irrefutable evidence, so the suspect can be convicted. To achieve this we need to develop:A DNA marker in which specific structures and compounds will be incorporated to increase its binding longevity and stability to proteins in human skin hair and clothes.An intruder detection system, this will be based on Video Motion Capture technology which will specifically detect the precise location of the intruder in a room. The information generated will then be relayed to a dispersal mechanism which will alter its trajectory to specifically target the intruder.A DNA dispersal mechanism, this will be based on inexpensive pyrotechnic technology and will be required to exert a sufficient force to spray an intruder wherever they may be in a room.The development of hand held DNA forensic analyser designed to be operable by t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LARGE STRIP ROLLING MILL' (1994-1998).

assistant: **Concept**

Energy savings, improvement of product quality (avoidance of cracking) and product diversity (IF steels) by application of a high pressure descaling system in a wide strip hot rolling mill. Innovative: hydraulic descaling system with rotating orifice caps and multitude of independent piston pumps operating at very high pressure, leading to flexible operation with reduced water and energy consumption.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Systematic search of RegulAtory elements coNtrOlling autosomal Monoallelic expression' under Horizon 2020.

assistant: **Concept**

Autosomal monoallelic expression (MAE) is an epigenetic phenomenon that controls the relative expression of maternal and paternal alleles in thousands of mammalian genes. Despite MAE’s widespread character the molecular mechanisms involved in its establishment and maintenance are yet to be clarified. Recent work shows that the sets of genes subject to MAE are highly consistent across individuals and conserved between human and mouse species. I propose to test that such conservation is due to specific regulatory elements in the genome associated with MAE genes. The strategy to discover such elements is via a systematic analysis of differences in genome-wide MAE patterns. In the outgoing phase of the Fellowship, I will be based in DFCI under the supervision of Prof. A. Gimelbrant. There, I will experimentally map MAE patterns in mice with highly divergent genomic backgrounds and identify loci that consistently differ between strains in whether they are MAE. Using computational methods, I will then determine whether particular motifs are associated with such variable regions. I will further assess the role of the candidate regulatory elements using specific F1 crosses and targeted mutagenesis. The analysis in the mouse will be complemented by comparative analysis of human and chimp matched cells, in order to narrow down the candidate loci list and shed light on the evolution of MAE. Successful completion of this project will establish the first model of genetic control of MAE and open doors to progress in the mechanistic and developmental understanding of MAE. On return to the TCD, under the supervision of Prof. A. McLysaght, I will be the link between two laboratories with a diverse research focus that would not be collaborating unless in the context of this Fellowship. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fairness in Language Models: Equally right for the right reasons' (FairER), addressing dissemination and exploitation.

assistant: **Impact**

Most of us use technology related to natural language processing (NLP) such as Google Search or virtual assistants in phones and other devices on a daily basis. Large-scale pre-trained language models hereby play a crucial role as they often form the basis of those technologies. Those models are trained on a large amount of training data (e.g. the entire English Wikipedia and the Brown corpus) which makes it impossible to curate the training corpus and potential stereotypes and biases will be implemented into the model, often without researchers noticing. This can lead to problematic and unfair behaviour towards certain demographics, often those who already suffer from implicit biases in society.With FairER, I aim to get a deeper understanding of the inner workings of these language models. In particular, I want to investigate how well their solution strategies align with those of humans and whether this depends on certain demographic attributes such as gender, race, age but also reading abilities and level of education. I will also probe those language models for fairness and inclusiveness, i.e., find out whether the performance of an NLP application depends on demographic attributes of the user. Furthermore, I will conduct this project in a multilingual setting and apply interpretability methods to better understand the rationale behind a models decision.The main impact of FairER will be a better understanding of how language models treat different demographics. These insights will help to improve the fairness and inclusiveness of NLP applications. Furthermore, the datasets I will record and publish along with the code will encourage other researchers to replicate my findings and continue this line of research. Ultimately, this project will have both a scientific and