RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mesoscale Brain Dynamics: Computing with Neuronal Pathways' to be submitted under Horizon 2020.

assistant: **Abstract**

Brain computations rely on proper signal flow through the complex network of connected brain regions. Despite a wealth of anatomical and functional data – from microscopic to macroscopic scale – we still poorly understand the principles of how signal flow is routed through neuronal networks to generate appropriate behavior. Brain dynamics on the 'mesoscopic' scale, the intermediate level where local microcircuits communicate via axonal pathways, has remained a particular blind spot of research as it has been difficult to access under in vivo conditions. Here, I propose to tackle the mesoscopic level of brain dynamics both experimentally and theoretically, adopting a fresh perspective centered on neuronal pathway dynamics. Experimentally, we will utilize and further advance state-of-the-art genetic and optical techniques to create a toolbox for measuring and manipulating signal flow in pathway networks across a broad range of temporal scales. In particular, we will improve fiber-optic based methods for probing the activity of either individual or multiple neuronal pathways with high specificity. Using these tools we will set out to reveal mesoscopic brain dynamics across relevant cortical and subcortical regions in awake, behaving mice. Specifically, we will investigate sensorimotor learning for a reward-based texture discrimination task and rapid sensorimotor control during skilled locomotion. Moreover, by combining fiber-optic methods with two-photon microscopy and fMRI, respectively, we will start linking the meso-level to the micro- and macro-levels. Throughout the project, experiments will be complemented by computational approaches to analyse data, model pathway dynamics, and conceptualize a formal theory of mesoscopic dynamics. This project may transform the field
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ultrasonographic monitoring and early diagnosis of stroke' to be submitted under Fifth Framework.

assistant: **Abstract**

The UMEDS project will establish non-invasive techniques for early diagnosis and bedside monitoring of stroke to improve stroke outcome. An important goal will be to expand recent developments in microbubble technology and ultrasonographic harmonic imaging to establish ultrasound techniques for both qualitative and quantitative evaluation of brain perfusion. UMEDS will develop new technologies to meet these goals. These include an automated system for detection of microemboli, a device for imaging the brain through the skull, a dual transducer system for microemboli detection and enhanced features for commercial applications of ultrasound perfuson imaging. We will investigate novel targeted microbubble technology for characterizing microemboli.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A new tool to guide consumers on how to mix and match foods to improve their blood glucose profiles', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Low pH foods can attenuate the glycemic response to starch-rich foods. It has been demonstrated that lemon juice, due to its low pH (pH≈2.3), inhibited key digestive enzymes thereby interrupting gastric digestion of starch in vitro. This effect can significantly reduce the glycemic response in humans. In particular, adding lemon juice to a starch rich meal reduced the mean blood glucose concentration peak by 30%. Considering the panoply of food options available, it is likely that other combinations have similar effects but no work has been conducted to develop a consolidated knowledge base to exploit this strategy.  GlucoMatchMaker will go beyond the state-of-the art by addressing this knowledge gap. The main goal is to develop and test the real-life effectiveness of the first mobile app to guide individuals on how to mix and match starchy foods with other foods/beverages to attenuate glycemic responses.The research work will employ multidisciplinary knowledge and methodologies and is divided into 4 parts (1) Selection and characterization of starch-rich foods, low-pH foods/beverages and of how their combination influences starch digestion in vitro (WP1). (2) Determination of the conditions of effectiveness of these combinations (in silico models) (WP2). (3) Development of the first mobile app that will integrate this knowledge to guide the user on how to mix and match starch-rich foods with others to lower their glycemic impact (WP3). (4) Test the effectiveness of the developed strategy in a real-life context (WP4).This project addresses the United Nations and EU target to reduce premature mortality from non-communicable diseases by one third as part of the 2030 Agenda for Sustainable Development. The research plan was developed in the framework of “H2020 Work Program
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Flexible, CMOS-Compatible PEALD-Grown MoS2 Memristive E-Skin Arrays for In-Sensor Neuromorphic Computing' (FLECS-2D).

assistant: **Innovation**

This project, FLECS-2D (FLExible CMOS-compatible e-skin Sensors based on 2D MoS2 memristors), aims to pioneer a new class of flexible neuromorphic devices by integrating low-temperature ALD-grown MoS2 memristors with tactile sensing arrays on polymer substrates. The central innovation lies in combining atomic-level control of 2D material synthesis with monolithic in-sensor computing architectures, enabling local learning and perception directly on flexible platforms. Unlike conventional CVD or exfoliated MoS2 approaches, which lack scalability and CMOS compatibility, this project employs plasma-enhanced ALD (<200 °C) to achieve uniform, defect-minimized MoS2 films on thermally sensitive substrates, ensuring industrial relevance and integration with silicon back-end processes. The fabricated devices will emulate biological synaptic behaviors such as long-term potentiation/depression and spike-timing dependent plasticity (STDP), enabling energy-efficient, event-driven computing critical for edge-AI, robotics, wearables, and biomedical electronics. The demonstration of 4×4 and 8×8 e-skin arrays will validate scalability, mechanical resilience, and real-time signal processing capabilities—offering a disruptive pathway towards ultra-low-power, adaptive electronics. Aligned with the European Green Deal and Digital Decade goals, the project addresses sustainability through low-temperature, low-energy fabrication methods and contributes to EU leadership in green, secure, and trustworthy digital technologies. It resonates with the Horizon Europe Cluster 4 priorities, advancing next-generation semiconductors and smart systems while reinforcing Europe’s independence in critical technologies. Beyond scientific impact, FLECS-2D provides societal and economic benefits: reducing energ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'VHDL-based system design and simulation environment' (VSDSE) targeting Fourth Framework.

assistant: **Abstract**

A model of the system under design is to be created before the implementation phase by using only VHDL models and a special component library (SmartModels).Verification of the functionality of the new system design is to be done only by using a VHDL simulator and component libraries (VHDL and SmartModels). No traditional gate simulator will be used.Special methods are to be introduced into the system testbench for automating the simulation process and result analysis and therefore improving the efficiency of development work.Design risks will be minimised, as decisions on architecture can be verified in a rather early stage of the design process.An earlier failure detection and shorter iteration loops will lead to shorter design periods.Verification of functional operability of the system to be designed by simulation will reduce the time needed for putting it into operation.In this Application Experiment a hardware design environment for hardware is to be established for complex PLDs as well as ASICs and PCBs using the same advanced top-down methodology, the same tools and similar flows in the system design before the implementation phase. VHDL which is an international standard was selected to form the basis of the work to be done. The design environment planned will enable us to perform VHDL-based board and system simulations in an early stage of product development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Co-ordination of research on genetic resistance to control plant pathogenic viruses and their vectors in European crops'.

assistant: **Objectives**

Plant viruses and their vectors cause serious economic losses, limit European crop production, and have negative effects on the quality and safety of food. The use of genetic resistance is one of the best ways to control plant viruses/vectors. RESISTVIR responds to topic T6.9 Use of genetic resistance as a tool to control plant pathogenic viruses, and aims to improve co-ordination of research on genetic resistance to plant pathogenic viruses/vectors, in European crops. This will ultimately result in new sources and mechanisms of sustainable resistance to plant viruses/vectors, being used in conventional and GM crops, and in decreased pesticide usage. The specific objectives are to ·Assemble information on the latest European & worldwide progress towards using resistance to control plant viruses /vectors and to provide future insights ·Co-ordinate cutting-edge European research ·Identify barriers to the development and use of new resistant varieties ·Encourage harmonisation of national and European standards, legislation, ethical issues, codes of practice & regulations related to GM and traditionally-bred crops for control of pathogenic viruses/vectors ·Develop a framework of suggested guidelines and recommendations of best practice ·Provide an on-line European database, linked to existing web sites and databases ·Promote exchange of European researchers ·Promote collaboration with European industry ·Disseminate the project's key findings to end-users ·Provide a framework to encourage complementary research programmes across the ERA The main outputs will lead to ·Better co-ordinated European research: less duplication of effort, more rapid commercialisation ·Increased awareness of the problems faced by plant breeders, geneticists, consultants and growers ·Improve suggest
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Molecular imaging of zinc in the brain'.

assistant: **Concept**

The number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be the calcium of the twenty-first century (Nature Rev. Neurosci. June 2005, vol. 6, 449-62). Up to now, Zn can be detected only in vitro and with limited accuracy, due to non-specific reaction of Zn chelators, which react also with Ca2+.Recently, some new fluorescent probes for Zn2+ were developed with increased Zn2+ specificity. 62Zn-EDDA was the only known to me Zn radiotracer used in PET monitoring of pancreas activity in dogs. PET registration in vivo of placement and dynamics of Zn containing proteins and small molecules will not have the same resolution as in vitro, but offers many advantages, among the most important, that the animal is its own control, and it is tested alive.I would like to develop and implement new PET radiotracer based on 62Zn, 63Zn or 65Zn that would allow in vivo registration of Zn2+ transport in the brain of small animals. The same isotopes will be used for imaging in vitro together with new Zn specific fluorescent probes.One of the areas of application will be research on expression of matrix metalloprotease 9 (MMP-9), which contains Zn in active site and structural Zn and Ca. The role of MMP-9 in plasticity of the brain was subject of my recent neurobiological research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ultra-sensitive multianalyte immunoassay based on dna-senor' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Objectives and content Whilst radio immunoassay (RIA) and enzyme-linked immunosorbent assay (ELISA) are well-established analytical methods in clinical laboratory, there is a need of ultra-sensitive multianalyte immunoassays for sensitive and reproducible quantification of analytes in many areas that are currently problematic, including diagnostic medicine and the standardisation of biological. The use of immuno-PCR in combination with a sequence-selective DNA-sensor based on micro-technology could provide the basis for the simultaneous detection of many analytes at low cost and at sensitivities higher than those of existing antigen detection systems. In a feasibility study suitable intercalators and electrode materials have been selected and double stranded DNA could be detected using amperometric method. In principle, therefore, this configuration is well suited for use as DNA-sensor. The purpose of this proposal is thus to develop a prototype for the simultaneous determination of two analytes based on novel sequence-selective DNA-sensor using micro-technology. To achieve this objective, the proposed research project will include:  development of immuno-PCR for the simultaneous determination of two analytes,  design and production of addressable electrode arrays in the microfabrication range for the DNA-sensor,  amperometric or potentiometric DNA-sensor for the determination of two different DNA as quantification step of the immuno-PCR,  development of the performance of the complete prototype system. This new technology will improve the quality of European industry in the area of new functionalised materials and new analytically methods since new innovative technologies and a totally new product will be developed and patented for the future world market which will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Diagnosis test for immuno-oncology therapies.' (IMMUNOTRAP).

assistant: **Innovation**

Cancers exhibit a large heterogeneity in terms of genetic mutations, so they respond differently to the same drugs. This is why oncology is rapidly drifting towards treatments with new disrupting personalised inmuno-oncology therapies based on adoptive T-cell transfer (ACT). These therapies aim at selecting the most efficient T cells against tumors and transferring them back to the patient. This kind of Immunoassays are generally carried out with endpoint measurements like Surface Plasmon Resonance or Flow Cytometry. However, these techniques do not allow assessing the binding process between the immune and the target cell, which represents a fundamental step of the recognition phase where large efforts against cancer focus.IMPETUX has developed a solution to address this unmet need. The characterization of this affinity will be achieved through the measurement of the interaction force between them with IMMUNOTRAP: a platform for cell screening based on IMPETUX‘s optical tweezers. This technology uses a highly-focused laser light to mechanically interact with the sample without physical contact. The recent 2018 Nobel Prize in Physics was awarded to the intellectual father of this technique for his ground-breaking invention in the 1980s. However, it was not until few years ago that forces could start being measured on non-homogeneous samples, such as cells, thanks to the technology developed by IMPETUX.The IMMUNOTRAP has the potential to become the workhorse in the screening of the best performance receptors for their use in immunotherapies and offers IMPETUX the opportunity to address a high-growth potential market: the pharmaceutical industry and clinical diagnosis. It represents, therefore, a key opportunity to boost the company’s growth.  Thus, the objectives of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analysis of early transcriptional activation and germ-line segregation in Drosophila melanogaster' (PGC), addressing dissemination and exploitation.

assistant: **Impact**

Early embryonic development relies on maternally encoded gene products. In Drosophila, such maternal proteins and RNAs are loaded into the egg during oogenesis, and they regulate multiple events in early embryonic development. As the number of nuclei rapid ly increases after fertilization, there is a maternal to zygotic transition (MZT), in which the soma suddenly becomes transcriptionally active, and many of the maternally encoded products are rapidly degraded.Although the MZT (also known in other organism s as midblastula transition) is a crucial transition during the early embryonic development, the molecular mechanisms controlling it are poorly understood. In contrast to the soma that becomes transcriptionally active during the blastoderm stage germ cell s remain transcriptionally repressed until later stages of embryonic development (Van Doren et al., 1998). This delay appears to be important for germ line segregation and avoidance of somatic differentiation. Yet, both somatic and germ cells appear to utilize a similar transcriptional regulatory apparatus. Germ cells are transcriptionally repressed because of additional germ-line specific pathways. We have shown that polar granule component (pgc) is specifically required for germ cells transcriptional repression (Martinho et al., 2004).The main aim of this proposal is to study the molecular mechanisms responsible for early transcriptional activation and germ-line segregation during early embryonic development. This proposal contains three specific research goals:1) Characterization of the molecular mechanisms responsible for transcriptional activation of the quiescent zygotic genome during MZT,2) characterization of the differences and similarities between somatic and germ-line transcriptional activation,3) further
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Meta-data extraction techniques for automatic indexing.'.

assistant: **Concept**

An important research activity within Oce Group Research is the development of document analysis & processing algorithms. These algorithms can be used to develop products and services to manage automatically huge flows of documents. The research on meta-data extraction techniques for automatic indexing, is divided in the following stages:1. Preprocessing. In this stage scanning artifacts are removed and the document image is positioned upright.2. Layout analysis. In this stage characters, tables and figures are recognized. Characters are recognized using OCR techniques.3. Genre classification. Information from earlier steps is used to classify the document as a book, report, and business letter, etc.4. Logical analysis. In this stage the functional meaning of the individual text blocks is determined, as well as the logical structure and reading order of the document. The goal of this research is to automate the classification, archiving and retrieval of large collections of documents. The research must lead to more knowledge on the structure and meta-data of various kinds of documents. At a later stage new software products in the document management field will be developed, based on this research. The fellows will be part of the research group and will participate in creating new algorithms and strategies and in validating these algorithms. Building up new and extending existing contacts with other research groups in the field is also a part of the training.