RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Unraveling the molecular dialogue in microbial-assisted plant growth in the presence of heavy metals'.

assistant: **Concept**

Agriculture is currently confronting (i) an increasing human population and (ii) limitations of soil use due to, among other reasons, pollution levels above food safety threshold values. Some agricultural practices increase the heavy metal content (HM) of agricultural soil, representing an important threat for the European agricultural development. The use of microorganisms as plant growth promoters has been increasingly studied for a number of years, but it has only recently been proposed to improve plant metal tolerance. Regrettably, plant-microorganism-pollutant interactions are still poorly understood and the molecular underlying mechanisms are mostly unknown. The abovementioned challenges for agricultural production require the study of these mechanisms to better promote a more efficient and sustainable agriculture. This project will venture into new unchartered territory by focusing on the molecular interactions between a probiotic actinobacterium (Micromonospora cremea) and its host, Pisum sativum (garden pea), in the presence of HMs. We will evaluate the capacity of M. cremea CR30 to improve plant tolerance to HM polluted soils, in addition to unraveling the molecular dialogue during the first and late steps of their interaction. Early step interactions are crucial in plant promotion and protection against external stresses, like pollution by HM. Here, we propose the use of new -omic technologies to study these molecular interactions between plants and microorganisms under metal stress, providing a new pathway for an improved soil management. This project addresses a crucial objective in food security, the development of sustainable agricultural practices to control potentially adverse HM effects on plant health.


**Keywords:** Plant-microorganism interactions,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Strategies for Microsphere-Mediated Cellular Control - A Technology to generate induced pluripotent stem cells for Regenerative Medicine' (RSM-MICROSPHERE-IPSC).

assistant: **Innovation**

A crucial goal of regenerative medicine is to generate desired cells, to build a specific tissue, from pluripotent stem cells directly derived from a patient's cells. These cells are known as induced pluripotent stem (iPS) cells and they have a potential therapeutic use as they offer an alternative to the controversial use of embryonic stem cells and, additionally, they avoid the issue of immune rejection. Nowadays the finding of an efficient and safe transfection method to introduce the appropriate genes (Oct3/4, Sox2, c-Myc and Klf4) into adult cells to obtain pluripotent stem cells is a bottleneck that could limit the use of iPS cells in humans. There is a need for a safe method for the production of pluripotent cells from adult human cells. Herein the development of a non-viral method for generating iPS cells is proposed. The broad aims of this research project are the design of novel strategies (based on solid phase chemistry) for the application, exploitation and development of a generic microsphere cellular delivery system for the release of a desired therapeutic cargo (such as DNA and protein) into adult human cells to induce the formation of iPS cells. This aims will be carried on by applying the skills in cellular delivery systems that the applicant acquired during her stay at the University of Edinburgh (UK) as a Research Fellow for the last five years. The project is a multidisciplinary approach with a synthetic chemical part to be developed at the University of Granada, where the applicant  has recently been incorporated as Lecturer in Medicinal and Organic Chemistry, and a biological part to be developed at the Andalusian Bank of Stem Cells  in collaboration with Dr. Garcia Perez, an specialist in the area of reprogrammation. The project deals with a topic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Emerging Research Areas and their Coverage by ERC-supported Projects' under Seventh Framework.

assistant: **Concept**

This project refers to the research topic Emerging research areas" within the CSAs of the ERC work programme. Its main objectives are to identify topically emerging re-search areas within all science areas and to analyse to what extent ERC-supported activities cover and contribute to these research areas. Thus we will investigate whether the basic mission of the ERC, namely "..to stimulate scientific excellence by supporting and encouraging the very best, truly creative scientists, scholars and engi-neers to be adventurous and take risks in their research" is reached in a satisfying way. Thereby the project also contributes to the question, whether the bottom-up approach of ERC funding meets the expectation of being able to support new lines of research with impact on the development of dynamic creative and innovative areas of research in Europe. The concept of our project combines two approaches. The first one concerns the identification of topically emerging research areas assuming that excellent, truly creative research can be found in particular in these emerging areas. Growth analyses will be combined with advanced bibliometric analyses (bibliometric coupling, cross-citation and text mining) and validated via expert assessments. The second approach comprises a mapping of ERC-funded research to emerging fields and an assessment of the ex-pected impact of ERC-funded research in terms of contributions to creative and innova-tive research areas in Europe. In addition ERC-funded research activities referring to distinct areas not covered by the landscape of emerging fields will be identified and assessed. Conclusions on the impact of ERC funding on stimulating research in emerging areas will be drawn and recommendations for optimizing ERC procedures will be developed. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preparatory Phase for a Deep Sea Facility in the Mediterranean for Neutrino Astronomy and Associated Sciences' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In the framework of the KM3NeT Preparatory Phase project the strategic, legal and financial issues are addressed related to the construction of an European deep-sea infrastructure housing a cubic kilometre size Cherenkov neutrino telescope and providing access for deep-sea research. Many technical issues are already addressed in the KM3NeT Design Study, started in 2006, that at the end of its work will deliver a Technical Design Report for the KM3NeT Cherenkov neutrino telescope. KM3NeT has been included in the ESFRI European Roadmap for Research Infrastructures. The Preparatory Phase will provide the grounds to bring the project to its construction stage.  The Consortium performing the Preparatory Phase will include the participants involved in the KM3NeT DS. The major stakeholders are present. The work performed in the Preparatory Phase will be structured in work packages aimed at addressing the following issues: political convergence towards a pan European facility; legal, governance and financial engineering; strategic issues and international networking; integration with regional and global marine and environmental systems (i.e. EMSO); preparing the production of the telescope components and the assembly and test of the system; definition of the data handling and dissemination scheme, and the operation of KM3NeT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sense&React – The context-aware and user-centric information distribution system for manufacturing' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The number of sensors and the amount of data gathered on the factory floor constantly increases. This opens the vision of truly connected production processes where information is exchanged seamlessly and in real time between humans, machines and the produced goods.However, it is a long way before the huge amount of information gathered and generated in separate disconnected sub-systems is presented in a manner that can truly speed up production processes, enable immediate reaction to issues and shortcomings.  Current Information and Communication Technology (ICT) installations in many cases fail at providing the right information, to the right people, on the appropriate time and in appropriate format while using the appropriate device.  This is mainly due to fact that these systems neglect their users' role, the context in which the users are acting and the user interfaces are often too complex and fail to adapt to user current context.Sense&React considers context awareness to be a fundamental property of ICT systems installed in modern production facilities.  Context awareness is the property for the provision of suitable services to a user through the analysis of his/her context.  Therefore, driven by industrial pilot cases, Sense&React will:\tImplement and validate ICT reference architecture for enabling intelligent management of manufacturing information in real-time and that can be used to develop context-aware applications for the industrial factory-floor.  Sense&React will develop the necessary hardware and software modules required to gather and process data from different date sources such as sensor networks, MES and ERP in order to build the current context.\tDefine a factory wide sensing and ICT end-to-end infrastructure for sensing and aggregating data f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the Role of Interfacial Effects on Corrosion Thermodynamics in CCS' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Corrosion has enormous economic, safety, and environmental impacts. In CO2 capture and storage (CCS), CO2 and acidic impurities can significantly accelerate corrosion when water is present. When the water composition is below the solubility limit in the CO2-rich phase, water can still form thin films with a thickness of only a few nanometers at metal surfaces. In thin films, dissolved gases and metal cations form a complex aqueous system that involves thermodynamics, chemical reactions, and interface science. Corrosion below thin films is called dry corrosion and is a phenomenon largely influenced by interfacial effects. By combining fundamental thermodynamics with interfacial models, InterCorr aims to reliably predict when dry corrosion can occur across wide ranges in temperature, pressure, and compositions, extending beyond the range of existing experiments and empirical correlations.InterCorr will develop a consistent thermodynamics framework in bulk systems and below thin films, providing a modeling tool as well as new insights into how interfacial effects influence the solubility, pH, chemical potential, density, and other key thermodynamic parameters that have direct impact on corrosion. Developments in this project can help develop new, more affordable corrosion-resistant alloys and better ways to prevent corrosion.


**Keywords:** Thermodynamics, Electrolyte solutions, Statistical associating fluid theory (SAFT), Classical density functional theory (DFT), Dry corrosion, CO2 capture and storage (CCS)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cell-free Ti-based Medical Implants due to Laser-induced Microstructures' (CellFreeImplant).

assistant: **Concept**

New miniaturized and smart medical implants are more and more used in all medical fields, including miniaturized pacemakers. These implants with a casing consisting often of a Ti-alloy may have to be removed after some months or several years and shall therefore not be completely overgrown by the cells. In the framework of the ongoing FET Open project LiNaBioFluid, we successfully demonstrated that self-organized sharp cones or spikes at Ti-alloy substrates created by pulsed laser-ablation can result not only in complete wetting by water and body fluids but at the same time provide too little surface for the cells (i.e., fibroblasts) to grow on. Compared to flat surfaces, the cell density on the microstructures is significantly lowered, the coverage is incomplete and the cells have a clearly different morphology. The best results regarding suppression of cell growth are obtained on structures created by femtosecond Ti:sapphire laser irradiation, which are subsequently electrochemically treated. The goal of the Coordination and Support Action CellFreeImplant is to find strategic partners (end-users) for future development of smart medical implants addressing wide-spread patients needs for instance in the field of cardio-vascular diseases. The project activities include the identification of the market segments and needs and assessment of the technology with end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultralight Dark Matter Detection and Characterization with LISA' (ULDM-GW).

assistant: **Innovation**

Despite compelling astrophysical and cosmological evidence for dark matter, its nature remains unknown. Ultralight dark matter (ULDM) is a well-motivated candidate, producing distinctive signatures that can be probed with gravitational wave (GW) interferometers. Spin-0, spin-1, and spin-2 ULDM couple differently to Standard Model particles, inducing measurable effects in GW detectors, but distinguishing between ULDM spins, and between ULDM and continuous astrophysical GWs, is challenging due to signal similarities. This project will exploit LISA’s low-frequency band and orbital configuration to detect ULDM in a frequency band unexplored by ground-based detectors and discriminate signal types through their characteristic polarization content. By combining theoretical modeling of ULDM signals with dedicated search strategies, we will develop the first end-to-end LISA pipeline capable of both detecting ULDM and constraining signal type. The project will be carried out in CEICO-FZU (host) and L2IT-CNRS (secondment), with strong expertise in ULDM and LISA science respectively. We will establish waveform templates and signal characteristics in both time and frequency domains, develop a semi-coherent search and a fully coherent search for ULDM in LISA, and will forecast how effectively polarization measurements can distinguish between spin-0, spin-1, and spin-2 ULDM, and continuous astrophysical GWs. This approach will deliver the highest sensitivity to ULDM across LISA’s frequency range, surpassing existing experimental limits by orders of magnitude, while providing a robust framework to differentiate candidate signals. The outcome will advance both fundamental dark matter searches and GW data analysis, establishing LISA as a powerful probe of the dark sector.


**Keywords:**
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'EARLY DETECTION AND INTERVENTION IN SMOLDERING MULTIPLE MYELOMA: POPULATION-BASED SCREENING AND TREATMENT'.

assistant: **Objectives**

Multiple myeloma (MM) is a bone marrow malignancy that is always preceded by asymptomatic precursor conditions, monoclonal gammopathy of undetermined significance (MGUS) or smoldering MM (SMM). SMM is a more advanced precursor and is associated with a high risk of progression to MM.  More than 94% of MM cases are diagnosed when already at the stage of full-blown malignancy and therefore do not benefit from the impact of early treatment. Recent studies indicate a benefit of early treatment but all prior SMM studies are based on patients diagnosed due to other medical issues and are therefore biased. There are important and urgent questions on the role of screening and early treatment in SMM. There is also an unmet need to develop a risk score for progression that considers the biology and genetics of the disease. In Edit-SMM we plan to build on the success from the Iceland Screens, Treats, or Prevents MM (iStopMM) study, where remarkably over 54% of the population (N=80,759) consented to a nationwide screening for MM precursors. It includes clinical evaluation and follow-up, biobanking, cross linking to central health data registries, repeated questionnaires on patient reported outcomes, groundbreaking methods of detection of SMM, and in-depth genetics. Edit-SMM will identify all patients with SMM diagnosed in iStopMM. These will be followed and treated with the global objective of inducing a paradigm shift by improving diagnostics, disease classification, and population implementation of early intervention in MM by detecting and treating MM at a precursor state, hopefully leading to improved quality of life and potentially a cure. The main objectives are to gather knowledge on the epidemiological, clinical, and patient reported outcomes of SMM, perform a unique nationwi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Metabolic Theory of Microbial Ecology', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Theoretical ecology has genuine potential to revolutionise microbiology, and vice versa. However, current models, such as the Lotka-Volterra equations, are typically too simplistic to apply and test rigorously. Critically, these models fail to capture microbial metabolism, which my lab and others have found central to predicting the ecology of diverse communities. My goal, therefore, is to develop a new theory of microbial ecology, rooted in metabolism, and to rigorously test it. We will capture nutrient competition, cross-feeding, interference competition and phage, and build our framework using methods from statistical mechanics. Throughout, we will experimentally test our theory using the gut microbiota as a model system. We will address three fundamental questions: 1: What determines the composition and stability of communities? Theory will be parameterised with large-scale culturing on defined media, metabolomics and whole-genome metabolic models. We will empirically test our ability to predict composition and ecological stability, and to understand the diversity-stability relationship. 2: What determines ecological success? We will study what makes a strain successful within a community, incorporating metabolism, bacterial warfare, and phage predation. 3: How does the host environment shape microbial ecology? We will employ agent-based simulations to capture spatial structure and test them with a new in-vitro organoid model of the human gut mucosa and our new in-vivo imaging pipeline for mouse microbiomes. Our plans have risk because ecological systems are complex and hard to understand. However, our work promises to deliver a step-change in both ecology and microbiology by making the study of microbial communities a predictive science, where one can understand ah