RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Systems Medicine of Metabolic-Signaling Networks: A New Concept for Breast Cancer Patient Stratification' under Horizon 2020.

assistant: **Concept**

Breast cancer (BC) is a complex disease with high prevalence in the EU. 75% of the tumors are estrogen receptor-positive (ER+), and are treated with endocrine therapies (ET). MESI-STRAT will develop new concepts for knowledge-based stratification of patients into subgroups with different ET resistance mechanisms. We will establish predictive models for (1) patient stratification prior and during ET; (2) recurrence risk assessment when ending ET; (3) marker panel development to guide targeted therapies for ET-resistant patients; (4) novel ET resistance mechanism-based therapy design.  The unique collection of matched BC tissue, serum, and >10 years follow-up from the patient organization PATH is essential for the longitudinal analysis of ET resistance and relapse. Our team of oncologists, modelers, bioinformaticians and experimentalists will develop new computational models in combination with network analyses and pharmacogenomics, to integrate multi-omics data and explore metabolic and signaling (MESI) networks driving ET resistance. Metabolite marker panels measured in biological fluids will enable patient stratification, resistance monitoring and clinical decision-making. This is a new concept as BC metabolism is poorly explored for diagnostics and therapy. Upon successful validation in preclinical models, the predictive marker panels and related treatments will be jointly investigated by our clinical and industrial partners in clinical studies. Our 3 SMEs will closely co-develop the research, and directly exploit the MESI-STRAT results.  BC accounts for the highest cancer-related health-care costs in the EU. Our stratification concepts will increase cost effectiveness and the patients’ quality of life by (1) avoiding ineffective therapies, (2) marker detection in bod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Space borne measurements of arctic glaciers and implications for sea level.' (SPICE) under Fifth Framework.

assistant: **Objectives**

Sensors on space platforms offer unique opportunities for the study of ice caps. In principle it must be possible to derive from satellite data all components of the mass budget and their sensitivity to climate change. This requires integration of data obtained with different sensors, on different dates, and with a varying spatial resolution and quality of calibration. The goal of this project is to develop a scheme in which satellite data of a different nature can be combined to determine and monitor the mass budget of ice caps. In situ measurements will be collected and used to validate and improve retrieval schemes for Aledo, surface height, velocity, calving rate, and determination of glacier fancies. The target ice caps are: central West Greenland, vatnajokull (Iceland), Kongsvegen and Nordaustlandet (Svalbard), and Severnaya Zemlya (Russia).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Atmospheric co_2 and climate change during the cretaceous greenhouse: information from fossil plants' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Variations in atmospheric CO_2 are related to climate change (especially temperature) throughout geological time. In order to elaborate more accurate actual palaeoclimatic models for the Cretaceous, several analytic methods will be combined on the fossil conifer cuticles of Frenelopsis (Coniferales, Cheirolepidicaeae) and its chosen nearest modem relative Juniperus. A calibration of the inverse relationship between stomatal density or stomatal index on leaves, and ambient concentrations of CO_2 and climates will be performed. Transmission electronic microscope observations (up to x 200,000) can result in the definition of ultra structural types in Frenelopsis cuticles (the actual leaf matenals) and be a direct record of external constraints and climatic oscillations. Sigma^13C measurements in the living and fossil plants can yield new information on the water constraints, irradiance, atmospheric pCO_2 and temperature. The ecophysiology, geochemistry and ultrastructure technique for study of the structure of conifer leaf cuticles can yield important contributions to understanding Cretaceous Plants and greenhouse climate.I will learn new plant cuticle techniques (i.e. ultra-structure and geochemistry) and have access to important English fossil material. All necessary laboratory facilities are available at Leeds. I win receive support from an internationally renowned geochemistry group there and from the palaeobotanical group at Sheffleld that studies plant response to atmospheric CO_2 changes using carbon isotope analysis. I will benefit from the Cretaceous climate expertise of Dr Francis and her colleagues. I can also get extra training through their module in palaeoclimatology and the Centre for Biodiversity and Conservation (a Marie Curie Training Site). Ecophysiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Knowledge Assessment and Sharing on Sustainable Agriculture'.

assistant: **Objectives**

Conventional agriculture encompasses about half of the agricultural land territory of the UE countries; its negative impacts on the environment and the basic natural resources are recognised. Growing concerns of the society related to the environment deterioration such as water and food contaminations, livestock epidemics... compel to explore new ways able to improve the sustainability of the current farming systems. Alternative agricultural practices, technologies and approaches in support of sustainable agriculture have already been researched, developed, tested and implemented during the second half of the 20thcentury, in Europe but mainly in North and South America and Australia; they span million hectares. Learning from the results of theses experiences and researches and sharing lessons will undoubtedly contribute to define ways and tools able to orient European policy on sustainable agriculturedevelopment. KASSA proposal intends to build up a comprehensive knowledge base on sustainable agricultural practices, approaches and systems in support of European stakeholders: farmers and professionals, researchers and policy makers at local, national, European and global level. KASSA involves a critical mass of skilled partners dispatched up into four platforms: Europe, the Mediterranean, Asia and Latin America. It will be achieved through successive work sequences starting with a comprehensive inventory of existing results then continuing with a progressive refinement of the findings that alternate critical analysis and sharing of the results of each platform.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ceramide Synthases in Diabetic Beta Cell Demise' to be submitted under Horizon 2020.

assistant: **Abstract**

Sphingolipids including ceramides are building blocks of cell membranes, but also act as regulated intracellular messenger molecules. Emerging data indicate that sphingolipids are dynamically regulated by nutrients, and in turn control systemic metabolism, for example, by modulating insulin secretion, proliferation and cell death of pancreatic beta cells. Dysfunction and death of beta cells are key events during the development of diabetes, from which more than 400 million patients suffer worldwide. While pharmacological inhibition of general ceramide biosynthesis is protective against diabetes in animal studies, side effects of total loss of ceramides prevent medical implementation. The de novo synthesis of ceramides is fully dependent on six ceramide synthase enzymes (CerS 1-6), which are expressed in a tissue specific manner, and generate ceramides with different chain lengths. Currently, the functional roles and regulatory modulators of each CerS are unknown in pancreatic beta cells. Importantly, the downstream mechanisms by which ceramides impair beta cell function and eventually cause diabetes are not defined. Here, I propose to combine genomics, proteomics and lipidomics to assess the function of ceramide synthases expressed in mouse and human beta cells. Furthermore, both the subcellular localisation and the post-translational modifications of CerS will be determined. The ceramide-interacting proteins mediating the deleterious effects of ceramides will be identified by lipid-protein crosslinking and functionally tested. Finally, in a translational approach, we will test the ability of recently generated novel specific CerS inhibitors with improved specificity to ameliorate beta cell stress, and improve insulin secretion in mouse and human beta cells. In sum, we
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'On Line Interactive Mechanical Parts 3D-data base' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Using VRML modelling techniques, HTML, XML and Java languages, the aim of this project will be the development of data bases for small manufacturing companies that have assembling processes distributed in several locations, and in general, using parts from distant providers. The databases would contain the 3D parts representation and the ways they interact to get the final assemble. The software developed will let designers and engineers have a tool for distributed design via Internet, being possible to interact with different parts in the same way as having the parts themselves, in a user-friendly environment, low computer resources consuming. As a core part of the project, the different possibilities and uses of virtual reality interactivity and 3D webs applied to mechanical parts representation and assembling will be introduced in this kind of small companies through a wide plan of information and dissemination, first in Spain.Objectives:Using these VRML modelling language and Java, the aim of the project will be development of data bases for small manufacturing companies that have assembling processes that could be distributed in several locations or using parts from distant providers. Final objective will be to demonstrate the benefits to small manufacturing firms of the adoption of 3D interactive representation technologies through a controlled and well-focused experiment. We will make best use of several currently existing and available technologies, but in the context of a well-defined project a real business case of a small steel works company that will improve its representation techniques, precision and accuracy.Work description:WP1 - Management of the project, including Administration and co-ordination of project resources; keeping a good level of communicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Promoting virtual enterprises out of SME's' in the context of a Fifth Framework call.

assistant: **Objectives**

The new market trends force companies to look for high flexibility, reactive systems and high quality standards. The need to cluster and co-operate constituting Virtual Enterprises (VEs), supported by opportune technological tools and organisational methodologies, is the challenge that Small and Medium Enterprise (SME) especially very small sized, must face since now. Overcoming the critical mass in terms of employees, productive resources and competence, will be the key to become qualified partner of big enterprises, consequently without losing the SMEs lean structure. The successful experience matured in past R&D European Projects focused on VE, that has carried out methodologies and technologies to support VE problems, can finally be tested on the field and formalised by best practices. The summing up of the current SMEs way to work and the benefits produced by the proposed best practices will constitute the project.Objectives:Objective of the project is to define and experiment best practices to put very small enterprise with high collaboration potential in a position to constitute real Virtual Enterprises (VEs) able to compete in a market context with bigger enterprises, whose internal organisational models are well formalised. To do this, it is necessary to supply efficient methodological and technological supports, both during the delicate phase of VE constitution and during its normal operative phases. The ultimate objective of the project is to guarantee a wide adoption of the achieved results. In particular, the dissemination will take advantage of an effective presentation of the considered business cases. This will describe the general frame, the tested scenarios, the lesson learnt, the experiences, the expected and obtained benefits.Work description:The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Supplying ancient empires and medieval economies: Changes in animal husbandry between the Late Roman period and the Early Middle Ages in the Rhine Valley' (ZooRoMed), addressing dissemination and exploitation.

assistant: **Impact**

This project will investigate changes in animal husbandry between the Late Roman period and the Early Middle Ages, by comparing two different regions of the Rhine Valley: Basel Region (Switzerland) and North Rhine-Westphalia (Germany). The two geographical areas chosen for the project were frontier regions of the Roman Empire and were later located at the core of the Carolingian Empire. Research in different European regions during this period suggests that changes in the orientation and scale of husbandry practices reflect different socio-political conditions and economic strategies. Roman husbandry practices are known to have impacted considerably on the way domestic animals were raised in the various provinces of the Empire, in relation to a high degree of specialization of economic activities. The decline of the Roman political and economic structures and the development of feudal socio-economic structures had important consequences in animal husbandry practices, mainly in relation to the end of market-oriented production, and they include a self-subsistence economy, limited livestock mobility, no genetic improvement of livestock, and changes in management practices. The project will look for the reasons, timings and regional variations in the response (resilience or adaptation) of animal husbandry practices to the socio-political changes, including the progressive diversification of the production, the decrease of livestock size, the generalization of extensive or free range feeding regimes, and the limited mobility of livestock. For this, the project will undertake a thorough investigation of livestock body size and shape; integrate the zooarchaeological data with stable isotope analysis to investigate changes in the ways livestock was managed; and strive to under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of vaccines for sheep pulmonary adenomatosis, an endemic and contagious epithelial tumour' (SPAVACC) targeting Fifth Framework.

assistant: **Abstract**

Characterise the virological and immunological events in sheep during infection and vaccination with Jaagsiekte sheep retrovirus (JSRV). Evaluate several candidate vaccines. Provide proof of principle that a protective immune response to JSRV can be induced in sheep by vaccination. Brief description: The project comprises six integrated packages: - Development of techniques for the propagation and quantitation of JSRV: a recently developed infectious, pathogenic molecular clone of JSRV will be used to identify and optimise a permissive cell culture system for JSRV. Techniques to quantitate in vitro propagated JSRV in culture supernates and inocula will be optimised. A PCR protocol to detect JSRV viraemia will be optimised. Assays to measure ovine immune responses to JSRV: JSRV CA and SU sequences will be expressed in appropriate vectors to yield soluble products. The recombinant proteins will be purified and used to develop and optimise ELISAs for antibodies and assays for CMI responses to JSRV. Optimise challenge system to induce SPA in older lambs: in vitro propagated JSRV virions will be used to inoculate lambs. The effect of age at inoculation and virus dose to influence the incubation period and number of infected/affected lambs will be determined. The results will be used to set the best combination of dose and age that can be used for evaluation of candidate vaccines. Obtain infectious molecular clone of caprine enzootic nasal tumour virus (ENTV): a full-length provirus clone(s) of caprine ENTV will be obtained from a genomic library made from tumour DNA. Using knowledge and expertise gained in objective 1, the clones will be characterised to select an infectious molecular clone that will be employed to identify and optimise a permissive cell culture system for c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elucidating the role of biomolecular condensation in meiotic DNA double-strand break formation' (MeioticCondensate).

assistant: **Innovation**

Meiosis universally relies on the formation of DNA double-strand breaks (DSB) to initiate a genome-wide recombination program that promotes genetic diversity and is required to produce chromosomally-balanced haploid gametes. DSB formation is catalyzed by Spo11, which in acts in conjunction with nine essential partners in yeast, including the RMM proteins. We previously found that RMM undergoes DNA-dependent condensation, and proposed that this organizes intracellular sub-compartments within which controlled DSB formation takes place. The RMM proteins connect DSB formation to chromosome structure, and are subject to overlapping regulatory pathways that control the timing, position, and number of DSBs. However, the molecular assemblies that catalyze DSB formation and the mechanisms whereby they are regulated remain poorly understood. Here, I propose an approach that takes advantage of our established biochemical and molecular genetics techniques, combined with the development of novel methodologies, to unravel the central role of RMM condensation in DSB formation. Specifically, we will address the following outstanding questions: (1) What are the mechanisms of post-translational control of RMM condensation? (2) How does transcription impact condensation and DSB formation? (3) How does the chromosome axis affect RMM condensation? (4) What are the quantitative molecular interactions that underlie condensation? (5) Which proteins associate with RMM condensates? (6) What is the impact of RMM condensation on chromatin structure? This proposal harnesses our current knowledge of the molecular properties of DSB proteins to explore new models and hypotheses regarding the relationships between the DSB machinery and the cell. My goal is to gain insights into the molecular processes