RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Rapid adaptation to varying odor concentration'.

assistant: **Objectives**

In day-to-day life during navigation, hunting, escaping from predator and social interactions, animals rely on sensory information in general and on olfactory cues in particular. A general feature common to all forms of sensory processing is adaptation, whereby in the presence of continuous stimulation, sensory receptors exhibit a marked reduction in responsiveness. Perceptual adaptation attenuates neural and perceptual responses to sustained or redundant stimulation as means of enhancing the detection of new, transient stimuli. Rapid olfactory adaptation allows an animal to continually assess changes in odor environment and concentration  that are essential to follow odor plumes and trails. Current research aims to provide first insight on neural representation of complex, dynamic input by the mammalian olfactory system.Here I propose to combine precise control of odor stimulus, electrophysiology and behavioral readout in mice to ask: how olfactory system represents changes in odor concentration and how this representation depends on the statistics of the olfactory input? At the first stage responses of the olfactory system to simple switches in odor concentration will be studied. This will gain insight into the role of adaptation in the olfactory system. A second project will study how the olfactory system adapts to a time-varying stimulus with the final goal to form a quantitative description of temporal adaptation.The current research will provide the first physiological recordings in mammals in response to controllable time-varying stimulus. I will use behavioral readout to find which features of the neural code contribute to perception. Moreover, recording M/T cell activity in the context of behavioral tasks will strengthen the link between specific activity patte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bottom-up assembly of synthetic neural networks from biological matter' to be submitted under Horizon Europe.

assistant: **Abstract**

The long-term objective of my lab is the construction of “synthetic” neural networks from biological matter. In this way, we not only will understand how to build sustainable computing architectures but also provide a novel bottom-up approach towards understanding biological neural networks. To make progress in this direction, I ask: What is the minimal assembly of biological components that allows for bio-realistic electrical information processing? Clearly, voltage-sensitive ion channels form the molecular basis for electrical spiking activity in neuronal networks. However, spatial propagation of spikes is not a property inherent to individual ion channels but rather emerges from the arrangement of ion channels along a tubular lipid membrane, the axon. While the reconstitution of functional ion channels outside of living cells has been well established, the propagation of an action potential along a lipid bilayer nanotube has not yet been shown. Similarly, the physical realization of larger, non-living spiking networks using biological matter remains elusive. Here, I propose to move forward from the state-of-the-art by a) Studying action potentials propagating along lipid nanotubes and demonstrating their electrical cable and spiking characteristics b) Understanding the coupling between membrane elasticity and electrical characteristics and how electromechanical coupling remodels and reshapes membranes and nanotube networks. c) Exploiting these remodeling, reshaping, and self-healing abilities for biomimetic molecular mechanisms of information processing. This research is a challenge of enormous complexity. In this proposal, I argue that this challenge can be overcome using recent methodological advances. My preliminary data and my research experience combing electric
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Pushing the limits of detection in spintronic sensors into the femtoTesla range'.

assistant: **Concept**

Novel and compaImplementation of solid-state magnetic field sensors with ultra-high sensitivity and ultra-low magnetic-field detectivity is mandatory to accelerate the development of individualized and precision healthcare devices and promote the change to more energy efficient green technologies. Unlike other studies, the project will provide major advances in the field of spintronic tunneling magnetoresistance (TMR) sensors by pushing their limit of detectivity to the femtoTesla range without using external tools as magnetic flux concentrator, which is an artificial technique to increase sensitivity regardless to the origin of limitation in TMR multilayer structure as noise sources. For that, FEMTOSense is to pinpoint the origin and mechanisms that govern all noise contributions, and their control, on-demand, using materials science and device engineering. To do this, I will develop highly (001)-textured spinel oxide MgAl2O4 (MAO) tunneling barriers enabling tunable lattice matching with wide range of ferromagnetic electrodes particularly CoFeB, to suppress the interfacial imperfection (noise) at the interface and improve TMR ratio. I will also improve the quality of the ferromagnetic electrodes by development of functional sensing layers consisting of sandwich-like amorphous ferromagnet. The ferromagnetic sandwich comprises thin layers of super-soft NiFe inserted between amorphous phase of CoFeBTa ferromagnetic layers. The former is to prevent propagation of 111-texture of NiFe to MAO barrier, ensuring ordering interface with minimized electronic noises. The latter is to tune the structural and magnetic characteristics of the sensing layers, enabling high sensitivity and suppressing magnetic noise at the sensing layer. Finally, I will establish a framework to map all
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconnecting underground networks to maximise the flow and storage of carbon in forest soils', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In order to maximise the potential for habitat restoration initiatives to mitigate our grandest environmental challenges, we urgently need to understand how differing approaches to forest creation affect the recovery of belowground foodwebs and the carbon cycling processes they underpin. This is a formidable challenge: we know startlingly little about how natural climate solutions, such as large-scale reforestation, influence biodiversity and ecosystem functioning in the soil, the place where most species on the planet live and where 75% of terrestrial carbon stocks are found. Meeting this challenge not only requires a step change in our understanding of the form and function of complex soil biotic networks and the factors that mediate their reassembly with reforestation, but it also requires new knowledge of the mechanisms that underpin the formation of stable soil carbon stocks. The overarching aim of the RECONNECT project is to address these gaps by building the first complete picture of how contrasting reforestation approaches mediate the whole ecosystem movement of carbon from assimilation to stabilisation in the soil via differences in the reassembly of belowground biotic networks. To achieve this, I will use a unique and powerful combination of landscape scale field experiments, state-of-the-art molecular tools, isotopic tracing and cutting-edge biogeochemistry, to: (i) develop our mechanistic understanding of how contrasting woodland creation approaches (planting versus natural colonisation of trees) impact the flow, stabilisation and storage of carbon in forest soils, and (ii) determine how differing routes to forest creation influence the reassembly and functioning of interconnected mycorrhizal networks. In doing so, I will make major breakthroughs in our unde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Socrates and Plato on Epistemic Authority'.

assistant: **Objectives**

It often happens that we accept as true what other people tell us, and by doing so, we acquire knowledge about the world. We trust each other, and we often grant teachers and experts authority over our beliefs. The inter-subjective nature of belief formation has recently moved into the very center of epistemology. However, it is rarely mentioned that the reflection on the role of other people in our knowledge-acquisition has a distinguished historical pedigree, one that still deeply affects the way think about these issues. In particular, the Greek philosophers’ treatment of the notions of authority, trust, and disagreement has exerted strong influence on the subsequent history of philosophy. Up to now, however, there has been no systematic study of this important aspect of Greek thought. This project, “Socrates and Plato on Epistemic Authority”, focuses on the role attributed to what philosophers call “epistemic authority” (i.e. authority over belief) in knowledge acquisition and belief formation in the classical era of Ancient Greek philosophy (esp. in Socrates and Plato). Thus, the project aims to improve the understanding of Greek epistemology and to offer a historical background and an independent contribution to a central epistemological topic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mimicking liver disease and regeneration in vitro for drug development and liver transplantation' under Horizon 2020.

assistant: **Concept**

The liver is a vital organ for synthesis and detoxification. The most significant liver diseases are  hepatitis, non alcoholic fatty liver disease (NAFLD),  non-alcoholic fatty liver steatohepatitis (NASH), carcinoma and cirrhosis. An additional and important cause of liver injury is adverse drug reactions (ADRs). In particular NAFLD is the most common liver disease affecting between 20% and 44% of European adults and 43-70% of patients with type 2 diabetes, and is one prime cause for chronic and end-stage liver disease, such as cirrhosis and primary hepatocellular carcinoma.  This proposal is based on recent findings in the laboratory: The development of novel 3D spheroid system with chemically defined media allowing studies of chronic drug toxicity, relevant liver disease and liver function for 5 weeks in vitro, the finding of the role of miRNA in hepatocyte dedifferentiation and that hepatocytes during spheroid formation first de-differentiate but later in spheroids re-differentiate to an in vivo relevant phenotype. This forms the basis for the main objectives: i) to study diseased liver in vitro with identification of mechanisms, biomarkers and novel drug candidates for treatment of NAFLD and fibrosis, ii) evaluate drug toxicity sensitivity and mechanisms in diseased liver systems and iii) further develop methods for hepatocyte proliferation and regeneration in vitro for transplantation purposes, including genetic editing in cases of hepatocytes obtained from patients with genetically inherited liver diseases. This work is carried out in close contact with the Hepatology unit at the Karolinska Hospital partly using resources at the Science for Life Laboratory at Karolinska. It is anticipated that the project can provide with novel mechanisms, biomarkers and new targ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Foundations for Sustainable Security' in the context of a Horizon Europe call.

assistant: **Objectives**

Security and efficiency are often seen as a conflict. IT already consumes 11% of electricity globally, with a steep upwards trend. Resource sharing increases efficiency but introduces information leakage vulnerabilities, such as Meltdown and Spectre. Reducing reliability margins also increases efficiency but introduces fault attacks, such as Rowhammer and Plundervolt. This reveals a fundamental problem in current systems: Reliability mechanisms are not designed with adversaries in mind. Security is then patched on top of reliability mechanisms, incurring additional energy costs.We will overcome the conflict between security and efficiency with novel foundations to make security sustainable and use security to increase efficiency. We will research how to measure the efficiency of security, design principled and efficient security mechanisms, utilize security to increase efficiency, secure microarchitectural optimizations, and secure lightweight isolation.Our methodology is to integrate principled cryptography-grade security into all system layers to minimize and supersede inefficient reliability mechanisms. We will develop a framework for fine-grained energy efficiency measurements. We will research fine-grained replication for side-channel isolation, maintaining efficiency. We will explore selective resource sharing for secure variables, enclaves, and virtual machines, superseding today's inefficient and insecure techniques.The originality of FSSec stands out in that energy efficiency has played no role in security so far. In particular, using cryptography to replace established error correction methods will be the key to our goal of using security to increase efficiency by 20% compared to current systems. We will construct secure optimizations with fine-grained isolati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Redesigning aortic endograft: enabling in-situ personalized aneurysm healing', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Forty years ago, the endograft (EG) enabled the endovascular treatment of aortic aneurysm (AoA) and revolutionized vascular surgery. Still, since then, its technological concept has remained substantially unchanged: EG is a passive device aimed at treating the AoA in its late stage, not to cure the disease, even when discovered early. This proposal introduces a bio-engineered process to redesign EGs as 3D bio-printed, bioresorbable devices loaded with active drug components and validated in-vitro to enable the paradigm shift: from end-stage treatment to early personalized healing.To this aim, EPEIUS must tackle three open challenges: 1) available (animal) models often fail to predict human safety and efficacy for candidate therapies; 2) potentially effective drugs are challenging to deliver in therapeutic concentrations at the target; 3) consequently, there is a limited capacity of AoA healing even for compounds that were preclinically promising. We hypothesize that these challenges can be solved simultaneously by designing and fabricating a human in-vitro model of AoA where we can track AoA progression in the presence/absence of bioengineered EG, delivering therapeutic drugs. Grounded on a multi-disciplinary approach, EPEIUS will act as the “trojan horse” to enable the local healing of arterial walls.To verify our hypothesis, we will integrate 3D bioprinting and computational biomechanics to: Aim 1. Create an in-vitro model of AoA recapitulating dysfunction of endothelial and vascular smooth muscle cells, degeneration of extra-cellular matrix, overall driven by inflammatory state.Aims 2. Create a customizable EG to carry drug in-situ.Aims 3. Assess in-vitro the regenerative power of the mesenchymal stem cells’ secretome to heal AoA. EPEIUS will directly tackle a promin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Civil society and new migrants in superdiverse contexts' (SUPERDIVERSITY).

assistant: **Innovation**

This project investigates the role of civil society organisations (CSOs) for new migrants in superdiverse contexts. It explores whether CSOs are instrumental in the building of social relations during their settlement process. This social aspect of settlement, also described as social integration, is crucial regarding other aspects of settlement such as access to education, housing and the labour market. The project also looks at the role of CSOs regarding the relationships which long-term residents, both of ethnic majority and minority backgrounds, form with newcomers, addressing issues surrounding integration as ‘two-way-process’. The project will lead to novel findings because:• Rather than focussing on established ethnic minorities, it investigates patterns of integration of people originating from relatively new source countries who settle into already superdiverse contexts• It is situated within an emerging research field on new conditions of superdiversity which have rarely been explored systematically• It goes beyond existing quantitative work on civil society participation• It will develop theory around social contact, social capital and integration nuancing current thinking around the role of CSOs in settlementSuperdiversity has resulted from changing immigration patterns into Europe, with people entering cities in substantial numbers, and from far more countries of origin than ever before. This has resulted in a condition of more ethnicities, languages, religions, migration experiences, work and living conditions and legal statuses than many cities have ever faced (Vertovec 2007). By way of in-depth ethnographic fieldwork and interviews in two UK urban neighbourhoods, and drawing on existing theory, method and policy, the project will elicit how new migrants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced Research Workshop on Protracted, Intermittent or Chronic Irradiation: Biological Effects and Mechanisms of Tolerance""' to be submitted under Fifth Framework.

assistant: **Abstract**

It is proposed to organize a workshop to expand the scientific understanding of mechanisms that enable the mammalian organism to tolerate protracted, in remittent and/or chronic radiation exposure. Radiation accidents have occurred with exposures of persons for extended periods. Clinical signs and symptoms of failure of critical organ systems uncovered the cause of damage.However, the underlying patho-genetic mechanisms, the diagnostic tools available and therapeutic options are not well understood. The proposed workshop will revisit animal experiments and review approaches to study biological effects and repair mechanisms at the different biological levels (molecular, cellular, cell systems, organs and organisms) in order to develop a patho-physiological concept of tolerance and failure. It will also formulate research imperatives needed for secondary prevention of stochastic and deterministic late effects.The advanced research workshop on Protracted, intermittent or chronic irradiation" is organised to expand existing and develop new concepts regarding the mechanisms that enable the organism (experimental animals and human beings) to survive in elevated exposure fields of ionizing radiation.Of equal importance is the analysis of the patho-physiological mechanisms of a failure of cell- and organ-systems as a basis to develop means and ways to enhance repair mechanisms and to counteract the development of deterministic or stochastic late effects using cell renewal systems with rapid (e.g. hemopoiesis, skin) or slow (connective tissue, endothelial cells) cell turnover as examples.The workshop will bring together about 50 highly renowned experts in the field from 12 countries and it is envisaged to publish the contributed papers and especially the panel discussions releva