RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Impact of intensive antibiotic use on natural environment' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Increasingly, governmental bodies, including the European Union have emphasized the importance of the wide use of antibiotics, especially because of the emergence of microbial resistance. The aim of the project is to assess the impact on natural environment of the intensive use of antibiotics in agriculture, to predict its long-term consequences for human and animal health, and to propose solutions for better practices. This application proposes a three-year research project with two years fieldwork in Australia and a one-year return period in France.The project has six main objectives:(i) Sampling of natural ecosystems in space and time, according to the aquaculture practices,(ii) Determinate the fate of antibiotics in all compartments,(iii) Identify t he antibiotic-degrading microorganisms and resistance genes,(iv) Characterize the impact on microbial communities, and identify potential bacterial vectors of resistance genes,(v) Model the behaviour of antibiotics, predict their long-term impact, assess the global risk, and(vi) propose methods for antibiotic bioremediation, and molecular tools for evaluation of agricultural practices.This project will utilize a synergistic approach of tools from the applicant and the two host institutions, and will pro mote the collaboration between the partners. The Australian host research group has been chosen because it will provide unique preserved sites, specific environmental management skills and unique molecular methods to the applicant that are not available in Europe. This project will therefore be highly beneficial for the European host institution, the European Research Area, and the applicant's career. This is highly relevant to the core objectives of improved mobility, co-operation and structuring of the European Research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'WORK AND TRAINING INFORMATION SYSTEM' (WATIS).

assistant: **Concept**

The aim of WATIS is to develop an interactive self service multimedia information system on employment and vocational training to support the many citizens denied full access to data on EU-wide opportunities in this field. WATIS will provide such information cost-effectively in the appropriate language through different channels regardless of time and place, thereby enhancing EU professional mobility. Adaptable to the technological specifications and legal and other requirements of individual Member States, WATIS will be developed for maximum transferability throughout the EU.The labour market in the EU is evolving rapidly. Public Employment and Vocational Training Services such as the VDAB concluded that immediate action needs to be undertaken because the existing channels are no longer sufficient to cope with the increasing demands coming from the employers and the job-seekers. This is to the disadvantage of many EU citizens who are denied full access to the available information on employment and vocational training opportunities in their own country but also in other Member States of the EU.  The aim is to develop an interactive self service information system in the area of employment and vocational training with the use of multimedia. WATIS will provide EU citizens easy access to this information, in their own language and through different channels regardless of time and place, and this in a cost-effective way. This will improve job-mobility on a European scale.  Leaving opportunities to adapt the WATIS to the local situation and legal issues concerning privacy and the social legislation in the Member State concerned, the WATIS will be developed in view of maximal transferability to the other Member States of the EU. The possibilities for integration with the loc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New Micro-extrusion Advanced Technology for plant-based whole-cut meat substitutes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Due to the current overpopulation, climate change and aggressive animal farming problems, there is an urgent need for the next generation of alternative proteins meat. Based on tissue engineering, food science and 3D printing, NOVAMEAT has developed a micro-extrusion process that can bio-hack the native 3D network structure of molecules of plant origin creating the microstructure and anisotropic morphology like that of traditional animal meat in a cost-efficient and highly scalable manner. NOVAMEATs advanced and unique technology. The results are pieces of whole-cuts meat composed of a patent-pending formulation of a natural-origin wide range of different vegetable proteins, fibres, oils, and aromas that enable NewMEAT to achieve multiple varieties of nutritional, flavour and texturization profiles as animal whole-cut meats. NewMEAT does not contain soy but is composed of sustainable ingredients with much lower environmental impact, to support resilient agriculture and animal welfare.


**Keywords:** Bioproducts (products that are manufactured using,Environmental and Green Technologies,Industrial bioengineering,Bioprocessing technologies (industrial processes r,Food technology,Bioeconomy,Plant-based meat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transcriptional regulation and mechanistic insights on the telomeric lncRNA TERRA' (EnterTerra) targeting Horizon 2020.

assistant: **Abstract**

Telomeres, the heterochromatic structures that protect the ends of the chromosomes are transcribed into a novel class of long non-coding RNAs whose transcriptional regulation and functions are unknown. Telomeres protect the physical extremities of the chromosomes and they are are essential to genome integrity and stability. Dysfunctional telomeres have been detected in up to 90% of human cancers. We recently found that telomeres are transcribed from the subtelomeric region towards the end of the chromosome into the telomeric repeat-containing RNAs (TERRA). The identification of TERRA introduced a new field of research that demonstrates the structural and functional complexity unfolding at telomeres. Several lines of investigation have failed to elucidate the transcriptional activation network and functions of TERRA. The proposed research is built on a series of unrelated parts to explore the transcriptional requirements and the role of TERRA in the cells, employing a variety of different and revolutionary approaches. We plan to systematically identify the transcriptional factors that bind TERRA promoters and characterize their role in TERRA biogenesis (1). We will explore the dynamics of TERRA localization and determine if the transcripts remain attached to the sequence of origin or they can act at other chromosomal ends or loci (2). And finally we will elucidate the role of TERRA in stabilizing or recruiting telomeric or heterochromatic proteins at both telomeric and non-telomeric loci and assess their function on the chromatin (3). We expect that our innovative approaches will decipher TERRA’s localization preference on the chromatin, explore the multilayered ribonucleoprotein TERRA cluster, and it will provide new insights on plethora of telomere functions. Our studi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Influence of protein prenylation and its modulation on the immune system' (Pren-IBD).

assistant: **Innovation**

Prenylation is a postranslational process leading to changes in protein structure due to the incorporation of a lipidic moiety that significantly modifies their physicochemical properties and their behaviour. Prenylation is therefore a crucial step for key cell processes, such as interaction between proteins, cell and differentiation, cytoskeletal function and vesicular trafficking. The modification of prenylation is proposed as an attractive option in biological and therapeutic research, as its alteration can cause significant changes in cell biology. In fact, several prenylation inhibitors are currently included in preclinical and clinical research as anticancer agents (Sasaki M, 2003; Mach F, 2002). Many prenylation-modified processes can be considered of immune or inflammatory nature. In addition, a major substrate for prenylation reactions are small G proteins, which are involved in the activation of some relevant signaling pathways in the immune system. Thus, the immune response could be controlled by modulating prenylation.Specific cell-type inhibition of prenylation could be interesting allowing a better knowledge of its implication in cell biology considering several cell types related to the immune response. A novel technique for in vivo experiment is the genetic design of animals suffering from a cell-specific deficiency in the expression of a particular protein. This project is intended to study the influence of the lack of expression of one of the major enzymes involved in prenylation, GGTaseI, specifically in several cell types related to immune response, such as intestinal epithelial cells or lymphocytes. We will create strains by crossing Pggt1b-flox mice (Sjogren AK, 2007) with Villino-Cre mice (deletion of GGTaseI in epithelial cells) or with CD4-Cre m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fundamental interactions and the structure of space-time' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

A novel approach to (quantum) gravity and cosmology will be investigated. It is inspired by ideas of gauge-theory / gravity-string theory correspondence. The underlying theory generating gravity is a large-N four-dimensional gauge theory.The graviton is a bound state of glue. It will have a mass, which should be tiny as well as structure. This may give a solution to late acceleration and cosmological constant problems. Gravity is induced on the SM fields and the associated cosmology is of the mirage (probe -brane type).Gravity should be four-dimensional over a large range of scales via a combination of RS localisation and induced gravity mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering molecular mechanisms that resolve mutagenic DNA G-quadruplex structures' (ReXeG).

assistant: **Concept**

G-quadruplex (G4) structures are stable four-stranded nucleic acids assemblies that can form in guanine-rich DNA. Their recent visualization in mammalian cells has established G4 structure formation throughout the genome and fueled research into understanding the biological implications of these structures in cell regulation. G4 sequence motifs are abundant and conserved in our genome. G4 structures form transiently and regulate numerous cellular processes such as DNA replication, transcription and telomere maintenance. Importantly, these structures also come at a cost as they are able to induce genomic instability in certain cellular conditions, for example in cancer cells that suffer from replication stress.Currently, the mechanisms that form and resolve G4 structures are unknown. Several helicases can unwind these stable DNA structures in vitro but it is unclear whether and how these helicases function in vivo. Understanding the biochemical mechanisms that resolve G4 structures is crucial to further understand their function and how they induce DNA mutations in the cell.In this project, I propose to decipher the molecular mechanisms of G4 structures unwinding. The groundbreaking nature of this proposal is the use of a unique method to follow G-quadruplex unfolding in time under near-physiological conditions in vitro. This method, which was recently established in the host laboratory, uses DNA replication stalling and bypass at defined G4 structures as a direct readout for G4 stability and unwinding. This gives me the opportunity to address important aspects that have not been studied under physiological conditions before: Aim 1: To determine the stability and unwinding properties of distinct G4 conformations.Aim 2: To identify molecular mechanisms and novel proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Representativity Indicators for Survey Quality' (RISQ), addressing dissemination and exploitation.

assistant: **Impact**

Data that is missing due to nonresponse impose a serious threat to the quality of statistics that are based on both surveys and registers. In most cases nonresponse relates to demographic and socio-economic characteristics of the selected persons or enterprises and importantly also on the data collection process. In recent years a growing focus can be observed in survey research on differentiated data collection protocols and adaptive designs. The theory of Deming (1986) about improving quality and productivity in industry is well-known. Many of his famous 14 points for management also apply to the production of statistical information. Quality must be built in at the design stage. Deming’s points particularly apply to the data collection process.   The response rate is often used as an indicator of survey quality. However, literature gives various examples where increased data collection efforts led to a higher response rate but also to a larger or comparable nonresponse bias. Therefore, to assess the effects of nonresponse, other quality indicators are needed. These indicators should measure the degree to which the respondents of a survey or register still resembles the population. First examples of such Representativity Indicators have emerged recently. The main objectives of this project are to elaborate and develop these Representativity Indicators, to explore their characteristics and to show how to implement and use them in a practical data collection environment. It will be demonstrated that Representativity Indicators can be used in several stages of the data collection process to improve the quality of the resulting statistics. The project facilitates the efficient allocation of data collection resources and a sophisticated trade-off between quality and costs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spatial profiling of gastric cancer with peritoneal carcinomatosis to tackle cancer spreading and improve precision immuno-oncology' (SPARC) under Horizon Europe.

assistant: **Objectives**

The SPARC project tackles the urgent challenge of poorly cohesive gastric cancer (PCGC) with peritoneal carcinomatosis — an aggressive malignancy associated with a 5-year survival rate <30%. Despite advancements in GC treatment, effective therapies for PCGC with peritoneal spread remain inadequate, largely due to the tumor’s resistance to chemotherapy and the complex tumor microenvironment. This microenvironment is involved in hijacking cancer immune surveillance and supporting tumour outgrowth and invasion. However, the detailed molecular and spatial dynamics promoting PCGC dissemination are not yet fully understood.The project aims to fill this gap and elucidate the molecular and cellular mechanisms driving this aggressive behavior by employing advanced spatial immunofluorescence (IF) imaging and spatial transcriptomics to map the tumor and immune microenvironment of PCGC with synchronous peritoneal metastases, leveraging a rare biobank of treatment-naïve PCGC samples. This  will enable to better understand the complex cellular interactions that drive tumor growth, immune evasion, and metastasis, as well as identify and validate - at both protein and gene expression levels - novel biomarkers specifically associated with peritoneal metastasis, serving as potential therapeutic and prognostic targets for this challenging cancer subtype. The project leverages an interdisciplinary collaboration between leading research institutions – Karolinska Institutet (Sweden, host institution), Yale University (USA, secondment institution), University Hospital of Verona (Italy, collaboration partner) – and is supported by renowned experts in immuno-oncology and GC that will provide multidisciplinary training to the researcher, enhancing their career prospects while addressing a signif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ReSEARCH ACTIVITIES ON 3D WAVE HYDRODYNAMICS AND INTERACTION WITH STRUCTURES' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The Offshore Wave Basin (OWB) at Danish Hydraulic Institute (DHI) is a large and very versatile test facility, where realistic sea waves can be generated using the unique 60 flap wavemaker. All necessary peripherals (instruments, computers, etc) together with an experienced staff are available. The facility has been used by EU researchers under the HCM programme. The objective of making the OWB available is to provide a unique facility for verifying analytical and numerical models and for doing basic research within:  wave analysis and generation, wave hydrodynamics (wave kinematics), and wave-structure interaction Expressions of interest in obtaining access to the OWB have been received from 32 EU-based research groups. The evaluation of the Research Proposals will be coordinated through a common Scientific User Selection Panel for the parallel efforts undertaken by HR Wallingford (GB), Delft Hydraulics (NL), and Danish Hydraulic Institute (DK). DHI is an independent self-supported organisation. DHI has an international working atmosphere due to extensive involvement in international projects and R&D programmes, and due to an increasing number of foreigners in the staff. The environment is thus perfectly suited for hosting, supporting and training external researchers. The research activities will provide a unique opportunity for talented European researchers to advance the state-of-the-art within offshore and ocean technology, and allow themselves to become far more experienced and qualified for doing work on basic and applied research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development and implementation of a diagnostic, preventive and prognostic strain-level microbial test for peri-implant diseases' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Oral diseases are a global medical and socioeconomic burden. Diseases affecting dental implants (peri-implant mucositis and peri-implantitis) are particularly on the rise, and despite the plaque microbiome plays a crucial role in their etiology, the potential of profiling the microbial communities around implants for supporting implant care has not been exploited yet for clinical applications. The availability of metagenomic tools able to profile human microbiomes at unprecedented resolution developed within the ERC-StG MetaPG project and a pilot study we recently performed on the peri-implant microbiome are now enabling such tantalizing opportunity. In this PoC proposal, we aim to develop a product for dental clinics to provide clinically actionable indications for the prevention and treatment of peri-implant diseases by a combination of high-resolution strain-level metagenomic profiling and predictive machine learning methods. Such approach would overcome available clinical tests that are based on low-resolution molecular techniques that are inadequate at completely characterizing the plaque microbiome and do not offer a reliable support in the daily clinical practice to the dentists. By profiling and analysing 2,000 peri-implant microbiome samples collected from 50 dental clinics in the R&D phase, we aim to develop and validate a market-ready kit to (1) define a reproducible strain-level microbial signature for peri-implant diseases, (2) identify and characterize clinically relevant strain-level features of Fusobacterium nucleatum in mucositis, and (3) successfully support the clinical dental practice. Because inter-patient strain-level diversity of the plaque microbiome and of F. nucleatum in particular explains the variability in peri-implant health, our commercial