RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Future-proofing Heritage Buildings by Optimising Comfort and Energy in Time and Space' (HeriTACE).

assistant: **Innovation**

The HeriTACE project brings together a transdisciplinary team of research institutes, authorities, SMEs, and industry experienced in design, technology, and policymaking in the domains of conservation, buildings and energy. A significant increase in deep renovations of heritage buildings has the potential to lead to effective energy demand reductions and readiness for the transition to R2ES. Based on prior research and field knowledge supported by various EU and national projects, bottlenecks have been identified that prevent the futureproofing of heritage buildings and its replication. To overcome them, HeriTACE proposes innovative technical solutions, integrated into a holistic and multi-scale renovation approach, by developing and validating: (1) A replicable holistic assessment model and standardised processes to create a holistic vision and plan on the renovation requirements for heritage townhouses in historical neighbourhoods, (2) Optimal and integrated design approaches for the deep renovation of heritage townhouses, with well-considered, targeted and minimal invasive renovation measures, (3) Durable insulation and air tightness solutions for the renovation of building envelopes, respecting their heritage values and traditional building technology, (4) Optimised and smart controlled HVAC-concepts adapted to heritage townhouses, optimising comfort, and indoor air quality precisely where and when the building users need it, and (5) Integrated R²ES-based energy supply solutions, maximising the share of local R²ES in heritage buildings within historical neighbourhoods. The project will deliver solutions for authorities and designers to envision and govern a sustainable energy future for heritage townhouses in historical neighbourhoods, thus putting the EU Green Deal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Networking for Communications Challenged Communities: Architecture, Test Beds and Innovative Alliances' to be submitted under Seventh Framework.

assistant: **Abstract**

Leveraging diverse technologies in a coherent future Internet test bed is difficult. Extending the reach of such a test bed to people living in remote areas, that have special complex requirements, adds to the challenge. The target of the N4C project is the deployment and testing of ubiquitous and pervasive networking for communications challenged areas in a manner consistent with an overall vision for a future Internet that can encompass not just users and applications in well connected regions, but that can also reach out to rural areas. To achieve this goal N4C will make opportunistic use a range of communications access methods, but with a special focus on the presently evolving Delay and Disruption Tolerant Networking (DTN) architecture and related technologies that have mainly been developed by the Internet Research Task Force (IRTF) DTN community. DTN technology will be used to meet some specific goals for future Internet scenarios like methods of delivering information on global warming in almost inaccessible areas and providing means for including remote populations in future Internet society thus contributing to EC objectives eInclusion and Broadband for all.  A set of initial applications with specialized software and hardware will be tested in Sámi/Lapland in northern Sweden where a nomadic way of life is common and in Kocevje region in Slovenia. This will evolve into an on-going test bed for applications providing communications in challenged areas. The intent is that N4C will become an extension of a more general federated future Internet test bed for use in more traditionally connected regions. N4C will demonstrate sustainable business models for deployment of its outcomes. The impetus of working together in the FP7 framework will significantly improve th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improve Photovoltaic efficiency by applying novel effects at the limits of light to matter interaction' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The LIMA project exploits cutting edge photonic technologies to enhance silicon solar cell efficiencies with new concepts in nanostructured materials.  It proposes nano-structured surface layers designed to increase light absorption in the solar cell while  decreasing  surface and interface recombination loss. Integration in a back contact design further reduces these interface losses and avoids shading.The project improves light-matter interaction by the use a surface plasmonic nanoparticle layer. This reduces reflection and efficiently couples incident radiation into the solar cell where it is trapped by internal reflection.Surface and interface recombination are minimised by using silicon quantum dot superlattices in a passivating matrix. The  distance between quantum dots ensures wave-function overlap and good conductivity. An effective field at the superlattice - crystalline silicon interface ensures that the cell is insensitive to the recombination velocity at this heterojunction, and further increases the collection probability in the quantum dot layer.The dots allow a fundamental efficiency enhancement due to experimentally confirmed multiple exciton generation. This mechanism increases photocurrent and can in theory raise the theoretical single junction efficiency limit from 33% to 44%.These surface plasmonic and quantum dot layers are integrated in a high efficiency crystalline silicon back contact cell. This is designed such that the space charge region is separated from the superlattice – crystalline silicon heterojunction minimising non radiative space-charge recombination. The back contacts and dielectric electrical insulator are designed to maximise back surface reflection and enhance the light trapping of incident radiation without shading losses.The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Metabolism of DNA secondary structures and their impact on genome stability' (MetDNASecStr) under Horizon 2020.

assistant: **Objectives**

DNA replication is an essential process for genome duplication, cell division and ultimately organismal survival that ensures faithful transmission of the genome to progeny. Certain genomic loci represent major obstacles to DNA replication including fragile sites, G-rich tracts and repetitive sequences, such as ribosomal DNA and telomeres. Mammalian telomeres have the propensity to adopt complex DNA secondary structures, including telomere-loops and telomeric G-quadruplex DNA, which are believed to play essential roles in telomere maintenance. However, recent work has established that these structures are also a hindrance to DNA replication and failure to stabilise, repair or restart the replication fork is a potential source of genome instability, the hallmark of many diseases including cancer.Despite recent advances, the mechanisms that facilitate DNA replication at telomeres and other hard to replicate loci throughout the genome remain unclear. This proposal aims to address this important question in order to discover and decipher the mechanisms that help DNA replication through DNA secondary structures. I propose using multidisciplinary approaches to investigate the cellular response to replication stress at telomeres and the enzymatic activities that result in telomere replication aberrations, which will involve direct visualisation of telomere abnormalities using complementary DNA related methodologies and analysis of novel telomere-associated complexes. I also plan to determine the nature/structure of fragile telomeres, which remains poorly defined and represent a central question for the field using visualisation of biological molecules and proteomics.The detailed investigation of the function of known and new factors that facilitate telomere DNA replication rep
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Infection of the human intestine by enteroviruses: A CRISPR-based screening approach'.

assistant: **Innovation**

Enterovirus infections are of public health concern as globally millions of people become infected each year. Enteroviruses (HEV) are an assemblage of highly diverse positive-stranded RNA viruses that belong to the Picornaviridae family. Four out of the 13 known enterovirus species are human pathogens, with poliovirus being the most prominent member. The entry point for these viruses is the gastrointestinal or the respiratory tract from where they can spread to other organs and cause severe pathologies. Vaccines exist only against polio and no therapies are currently available against any HEV. Thus, there is a great need for new antivirals.I aim to identify host factors crucial for the HEV life cycle by performing a whole genome CRISPR loss-of-function screen in primary cultures of human intestinal epithelial cells. Importantly, the lytic nature of HEVs will allow a straightforward selection of cells that survive virus infection upon small guide RNA-mediated deletion of host genes that support HEV infection. This interdisciplinary project demands expertise both in stem cell, enterovirus biology and host-pathogen interaction, which is provided by the Jensen lab (host), the Tapparel lab (partner) and myself, respectively. Through access to intestinal stem cells and organoids from various donors and multiple HEVs I have the unique possibility to dissect host-enterovirus interactions by taking host and virus variations into account. By integrating this data, I will be able to dissect tropism both from a host and a pathogen perspective, and identify host factors that are necessary for HEV infection. This knowledge will contribute to the discovery of novel drug targets for broad-spectrum therapies against HEV infections and moreover provide me with the unique opportunity to m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Pliocene Constraints on Earth System Sensitivity'.

assistant: **Objectives**

The magnitude of long-term global temperature rise due to an increasing concentration of carbon dioxide (CO2) in the atmosphere is a question of relevance to policy makers and society. Previous studies have addressed this issue on the basis of the equilibrium response of the climate system due to fast feedbacks such as clouds and sea ice-albedo, often referred to as Climate Sensitivity. Plio-ESS will use the new concept of Earth System Sensitivity that additionally includes slow feedbacks such as those derived from changes in the major ice sheets and vegetation distribution. This has the potential to revolutionise the scientific debate on anthropogenic emissions of greenhouse gases and climate stabilisation targets. The aim of the project is to produce a robust estimate of the Earth System Sensitivity using the last interval in Earth history when CO2 was at modern or near future levels – the mid-Pliocene Warm Period. Using a combined modelling and geological data approach, Plio-ESS will integrate reconstructions of mid-Pliocene vegetation and ice sheets into climate and Earth system models. In this context Plio-ESS will push the frontier of palaeoclimatology by using state-of-the-art models which will enable the importance of resolution, improved model physics and the inclusion of additional Earth System components on model estimates of Earth System Sensitivity to be identified. Ensembles of experiments exploring the plausible range in model boundary conditions and physics will also quantify the uncertainty on estimates of Earth System Sensitivity. The outcome of the project will be a rigorous estimate of Earth System Sensitivity, which can be used by climate scientists and policy makers in defining stabilisation targets for greenhouse gas emissions and global temperatu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Less is more: Single Cell Analysis of Zebrafish Blood Development' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Blood stem cells need to both perpetuate themselves (self-renew) and differentiate into all mature blood cells to maintain blood formation throughout life. However, it is unclear how the underlying gene regulatory network maintains this population of self-renewing and differentiating stem cells, and how it accommodates the transition from a stem cell to a mature blood cell. Our current knowledge of transcriptomes of various blood cell types has mainly been advanced by population-level analysis. However, the population of seemingly homogenous blood cells may include many distinct cell types with substantially different transcriptomes and abilities to make diverse fate decisions. To overcome these limitations, I will use single-cell transcriptome sequencing of zebrafish blood cells. I will apply an integrative strategy, combining genetic perturbation with computational sequence and network analysis methods, to reconstruct the regulatory networks that maintain the dynamic balance between different blood cell types. This will be achieved by pursuing two main aims:1) I will create a comprehensive atlas of single cell gene expression in adult zebrafish blood cells and computationally reconstruct the blood lineage tree. I will order cells according to their most likely developmental chronology and identify genes and gene regulatory networks that define distinct cell types. The completion of the first aim will be followed by a more ambitious long-term one that is based on:2) The in-depth functional characterisation of a subset of novel key regulators of blood formation and identified cell types in vivo. To achieve this I will generate a number of loss-of-function and transgenic zebrafish lines.By sequencing thousands of single cells, this study is poised to go beyond traditiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Animation package for real-time simulation' (ARTIST).

assistant: **Concept**

The aim of the project is to develop an animation package for the development of real-time graphic applications including games, simulation and virtual reality. It will be a fully integrated package which can be used to generate graphics which are optimally designed for speed and to define the context-sensitive behaviour of objects used in applications.The package will solve several problems that are encountered with current systems:- Costs: Current systems run on expensive and dedicated platforms (workstations with high-cost/high-performance graphics cards). In contrast, the ARTIST package will run on a low-cost standard platform (a PC equipped with a relatively inexpensive rendering board). An interface will be provided to run on different graphics boards.- Development time: Animation tools do not incorporate mechanisms for defining context-sensitive behaviour of objects. Virtual reality applications do, but they lack the modelling and animation features. Neither incorporates mechanisms for efficiently linking behaviour and animation. ARTIST will provide a means for defining both the graphics and the context-sensitive behaviour of objects used in a game, simulation or virtual reality application. It will also enable these two aspects of the application to be easily linked, saving development time and improving the product's functionality and consistency.- Speed: Animation and modelling tools do not incorporate automatic optimisation algorithms for defining graphics databases. The ARTIST package will generate graphics database structures that are optimised for speed and which take maximum advantage of the graphics hardware.- Risks: The current risk of being obsolete before reaching the market aimed for (e.g. games, virtual reality or simulation) is high because such ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Higgs precision era at the LHC' (HIGGSEFT), addressing dissemination and exploitation.

assistant: **Impact**

We are at a  very special point in  space and time.  The Large Hadron Collider has experienced a first very successful physics run that culminated with the discovery of the long sought-after Higgs boson. We have begun probing the substructure of nature at unprecedented 10^(-17) cm distances,  corresponding  to the energy scales of the few  TeV.  The goal of this project is to develop a formalism to bring the study of the recently discovered Higgs boson into a  precision era. With the discovery last year of a new resonance that is identified as the long sought-after Higgs boson with a probability better than 1-10^(-13), a new era started in the understanding of the Standard Model (SM) of particle physics. In the absence of any evidence for any other new degree of freedom at the weak scale, a mass gap is likely to separate the SM particles from the dynamics generating and stabilizing the Higgs potential. Our ignorance about the New Physics sector can thus be conveniently parametrized in terms of a set of higher dimensional operators built out of the  SM blocks and obeying the simple SM symmetries laws. The Higgs data collected by the ATLAS and CMS  experiments (as well as by the 2 Tevatron experiments) start putting interesting bounds on the  8 unconstrained deformation directions affecting the Higgs physics. Two  lines of research will be developed in this project: 1/ the identification of the best variables to characterize the Higgs data  in analogy with the oblique parameters that were introduced to study EW data, 2/ the computation of next-to-leading corrections for the Higgs production and decay rates in the presence of  higher dimensional operators deforming the SM.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Euro Summer School on Medical and Biophysical applications of NMR using hyperpolarised gases' under Fifth Framework.

assistant: **Concept**

The area of medical and biophysical applications of Nuclear Magnetic Resonance (NMR) using hyperpolarized gasses is relatively new. The method has substantially improved and accelerated some of the existing diagnostic methods in life-sciences. The idea of using the NMR technique on hyper polarised gases was recognised in 1994 and published in Nature vol 370 July 1994. The innovation of the topic has appeared from a number of multidisciplinary subjects brought together, which resulted in new applications of hyperpolarized gases. Thus, new research topics have opened up in vast areas of science in relation to production and application of the hyperpolarized gases such as in laser physics, materials science, spectroscopy, medical physics, radiology, and lung studies. The technological medical applications of the method to biology/biophysics, neurology, and lung studies have been widely developing during the last years. Because the field is multidisciplinary and new the subject is not presented as a whole at universities.Therefore, it is important for the expansion of this field to present to the forthcoming generation of scientist the area of hyperpolarized gasses by introducing both the multidisciplinary scientific background and the fascinating area of technological applications of this method. It is planned to organise a 1-event Euro-Summer School. The Euro Summer School will be the first school to address the potential applications of hyperpolarized noble gasses. The school will introduce this new area to students from various fields thereby stimulating the European potential for research and applications within this promising area. The summer school will help to expand the network, that can be used later in the work of existing groups working with hyperpolarised gases