RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The influence of copper status on age-related changes in human immune function and gene expression.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Immune determinations and DNA-micro arrays will be employed to establish whether copper is a potential enhancer of immune function and regulates gene expression in the elderly. The micro arrays technology will be also learned by the applicant to apply it to the European VITAGE project (QLK1-CT-99-0830).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Product configurators:confusing or confuguring' (1994-1998).

assistant: **Innovation**

The main objective of this research proposal is to increase the use of product configurators, and thereby improve the competitiveness of European Industry. To meet this objective it is necessary to take away barriers to implement a product configurators (technical and organisational aspects) Research is required to:- definition of a framework for the applicability and limitations of product configurators in specific business environments - development of a general implementation method for product configurators, including aspects as: - rules for product design - translation of existing bills of material to a generic bill of material - educational programme to train people at several positions in the organisation structure in the use of a product configurators -development of improved specifications for product configurators The developed tools and methods will be in a pilot situation implemented at the SME's. The results will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'ViroLab: A virtual laboratory for decision support in viral diseases treatment', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

We propose to develop a Virtual Laboratory for Infectious Diseases that facilitates medical knowledge discovery and decision support for e.g. HIV drug resistance. Large, high quality, clinical and patient databases have become available which can be used to relate genotype to drug-susceptibility phenotype. The relevant data has two main characteristics: it spans all temporal and spatial scales from the genome up to the clinical data; it is inherently distributed over various sources (virological-, clinical- and drugs-databases) that change dynamically over time. Using a Grid-based service oriented architecture, we `vertically¿ integrate the biomedical information from viruses (proteins and mutations), patients (e.g. viral load) and literature (drug resistance experiments), resulting in a rule-based decision support system for drug ranking. The Virtual Laboratory supports tools for statistical analysis, visualization, modeling and simulation, to predict the temporal virological and immunological response of viruses with complex mutation patterns to drug therapy. The Virtual Laboratory provides the medical doctors with a decision support system to rank drugs targeted at patients. It provides the virologists with an advanced environment to study trends on an individual, population and epidemiological level. By virtualizing the hardware, compute infrastructure, and databases, the virtual laboratory is a user friendly environment, with tailored workflow templates to harness and automate such diverse tasks as data archiving, data integration, data mining and analysis, and modeling and simulation. HIV drug resistance is one of the few areas in medicine where genetic information is widely used for a considerable number of years. Large numbers of complex genetic sequences are av
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Lead-cooled System' to be submitted under Sixth Framework.

assistant: **Abstract**

The GEN IV initiative considers fast reactors mandatory for a sustainable development of the Nuclear Energy. Europe has a large experience in the field of sodium-cooled fast reactors (e.g. SPX1) and has made a big effort in the Lead-Bismuth Eutectic (LBE) technology for use in the sub-critical reactors in both the past FP5 and the ongoing FP6. The natural development is the use of pure lead since less expensive, less corrosive and of lesser radiological concern than LBE. Lead is chemically inert and has good neutronic characteristics that are unique among the coolants for a fast reactor. The ELSY project aims at the demonstration that it is possible to design a competitive and safe fast power reactor using simple technical engineered features. The high lead density has the advantage that, in the hypothetical case of a core disruption, it is unlikely to lead to core compaction scenarios which might cause the insertion of large amounts of reactivity in a short time. The use of compact in-vessel steam generators and of a simple primary circuit with possibly all Internals being removable are among the reactor features for competitive electric energy generation and long-term investment protection. Europe is taking the initiative to promote this ambitious project and it_s relevant to note that the FP6 is the last opportunity to carry out a very innovative activity with participation of young engineers and scientists, who would learn from engineers and scientists near to retirement with large experience in fast reactors design. GEN IV Partners outside Europe are also willing to participate in design and development of a common large-scale LFR. The activity consists of management and technical activity subdivided into six Work-Packages: WP1: Design objectives, cost estimate, fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BIO-PHOTONIC IMAGING OF THE INFANT BRAIN, THE MISSING LINK BETWEEN THE CELLULAR BRAIN DAMAGE AND THE NEUROVASCULAR UNIT DURING ACUTE ILLNESS'.

assistant: **Objectives**

The brain of the newborn is very different from the adult posing a major problem in assessing the origins of its injuries and in developing therapeutics. This is further complicated when the newborn was born prematurely or its in-utero development has been compromised. In these situations, their interplay between contributing factors become complex to understand with current tools since they are technically and ethically difficult to employ widely. TinyBrains will develop a neuro-imager and focus on congenital heart-defects (CHD). CHD is the most prevalent congenital malformation with about a million births worldwide annually. Advances in surgical techniques and perioperative management have dramatically reduced mortality rates with more than 85% surviving to adulthood. However, significant neurodevelopmental problems are observed in about 50%  due to brain injury. It being so prevalent and also having accepted accionable points in its care and therapy, TinyBrains chose CHD as its target to provide a research platform to improve the understanding of the cellular origin of the brain injury by enabling the assessment of the link between energy demand and oxygen supply. To so, we will combine advanced biophotonics technologies and electroencephalography into a disruptive research tool enabling research into new brain-oriented therapies and management strategies. TinyBrains will measure cerebral hemodynamics, oxygen metabolism and electrophysiology simultaneously. In vivo imaging in three-dimensions, i.e. tomography, will greatly increase the brain specificity and penetration as well as, for the first time, providing spatial resolution to this class of measurements. This plethora of information will enable us to carry out pre-clinical animal and clinical studies in infants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Development and testing of an objective mesh gauge'.

assistant: **Objectives**

The project evolves from the need for an objective mesh gauge to be used for fisheries inspection and research and by the industry. Previous work has shown that the present EU legislation for mesh measurement is not sufficiently precise and allows for variation in both the construction of the official wedge gauge and the operational procedures. It was recommended to develop a new, more objective mesh gauge.A new mesh gauge will be built and tested. The different tasks of the project are: to build a prototype of the new instrument and to subject it to a series of acceptance tests; to compare the new instrument with the existing mesh gauges, both under laboratory conditions and at sea; to draft a protocol for using the new mesh gauge; to inform research institutes, fisheries inspectorates and the industry on the progress of the work and to give them the opportunity to comment and advice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mesoscopic computational imaging of the predictive listening human brain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

How do we understand the complex, noisy, and often incomplete sounds that reach our ears? Sounds are not perceived in isolation. The context in which we encounter them allows predicting what we may hear next. How is contextual sound processing implemented in the brain? From the sensory periphery to the cortex, complex information is extracted from the acoustic content of sounds. This feedforward processing is complemented by extensive feedback (FB) processing. Current research suggests that FB confers flexibility to auditory perception, by generating predictions of the input and supplementing noisy or missing information with contextual information. So far, limitations in coverage and spatial resolution of non-invasive imaging methods have prohibited grounding contextual sound processing onto the fundamental computational units of the human brain, resulting in an incomplete understanding of its biological underpinnings. Here, I propose to use ultra-high-field (UHF) functional magnetic resonance imaging (fMRI) to study how expectations shape human hearing. The high spatial resolution and coverage of UHF-fMRI will allow examining fundamental brain units: small subcortical structures and layers of cortex. I will investigate how responses change when acoustic information needs to be prioritized in an uncertain or noisy soundscape. Complementing UHF-fMRI measurements with magnetoencephalography (MEG), I will derive a neurobiological model of contextual sound processing at high spatial and temporal resolution. By comparing this model to state-of-the-art artificial intelligence, I will generalize it to naturalistic settings. This project links algorithmic and at a mesoscopic implementation levels to reveal the neurobiological mechanisms supporting hearing in context. The resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of a genetically modified brucella melitensis rev1 live vaccine and associated diagnostic assay allowing discrimination between vaccinated and infected sheep'.

assistant: **Concept**

Brucellosis in small ruminants caused by Brucella melitensis is the most widespread form of animal brucellosis in the mediterranean countries of the European Union (EU). The main problem is due to sheep brucellosis which is responsible for important economic losses through interference with breeding programmes and reduction in milk yield, and also constitutes a serious hazard to public health as B. melitensis is very pathogenic for humans. In the same regions, the ram contagious epididymitis caused by Brucella ovis is also a disease of economical importance. In the southern Europe where sheep brucellosis is endemic, efforts are still to be made to reduce the prevalence to a level at which the elimination of infected animals is economically feasible. At this stage, vaccination is the only suitable method for controlling the infection in animals and thus constitutes a real priority. B. melitensis strain Rev. 1 is worldwide accepted as the reference live vaccine against B. melitensis or B. ovis infection in sheep. Rev. 1 has however a serious side effect due to its interference with the serological diagnosis of the field infection. This interference does not allow discrimination between vaccinated and infected animals, thus making sanitary management more difficult to achieve. Therefore, the development of an effective live vaccine devoid of this disadvantage is highly desirable and justified. The objective of this project is therefore to develop a stable vaccinal strain of B. melifensis Rev. 1 devoid of specific diagnostic proteins by gene replacement technology which, by virtue of lacking genes encoding these proteins, would induce protection but would not induce antibody response against the missing proteins. The use of these antigens, produced as recombinant proteins,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cooperation for European Research in Economics' to be submitted under Seventh Framework.

assistant: **Abstract**

The European Union is the world's largest economic entity, yet its ability to design and implement effective economic policies is not commensurate with its size. While the field of economics has seen an impressive growth, the economic research remains fragmented across the Member States. Developing an efficient research area is essential for growth and to the process of European integration. However, a variety of informal barriers inhibit the free flow of research funding, as a result, the efficient allocation of R&D funding. Research grants can provide a viable tool to circumvent limits to integration and to enhance the exchange of ideas. However, if not designed correctly, research funding can also aggravate the initial problem. This proposal outlines how the European Economic Association will go about creating the COEURE (COoperation for EUropean Research in Economics) network, which will bring together key stakeholders in the European economic research space and funders of research. COEURE will launch a global process that will lead to the formulation of an Agenda for Research Funding for Economics in Europe (ARFEE). First the project involves taking stock of the current state of research in key sub-fields in economics to map out the research frontier and the activities of European researchers. It identifies key open research questions and suggests ways in which research on these issues should evolve, notably to better address the policy challenges that Europe is now facing.  Second the project assesses the extent to which mechanisms for funding economic research in Europe have supported research at the frontier in the past, and suggests ways in which they might evolve in the future to support it more effectively. Third the project brings together stakeholders to fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CellsBox: a modular system for automated cell imaging experiments' (CellsBox).

assistant: **Concept**

Based on research from ERC CoG HydroSync where we developed both hardware and software approaches to cell imaging, we are in the position to develop translationally a cell culture and imaging unit, with integrated modular hardware and analysis software allowing automated robust performance. This promises to not just significantly bring down the costs for a broad spectrum of cell biology and single cell imaging experiments. It will also make these experiments more reproducible, systematic and easily accessible in standardised fashion. Perhaps most important of all, by designing in an integrated (whilst modular architecture) system all the components of the experiment (optics, mechanics, cell environment and fluids control, cell sample chambers, analysis), we make it possible to rapidly feedback information on the state of the sample into actions by any of the other modules, thus allowing a new space of experimental design.  This automation in running the experimental stage of cell biology, microbiology, infectious disease models, early embryo developmental work, etc (i.e. any of the many situations where one aims to follow the properties of individual cells) also aligns to the current revolution triggered by machine and deep learning approaches. We can imagine a day when integrated experimental ""CellsBoxes"" perform, in a hypothesis-driven optimised and tireless fashion, a battery of experiments that today would simply be inconceivable.   This project addresses one of the experimental bottlenecks that still make too much of biological and medical research subject to bias and poor reproducibility, and change the nature of point-of-care cell tissue analysis. It will be disruptive in the current landscape of optical cell imaging, a market > $1bn globally.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'AN INNOVATIVE METHOD TO DESIGN 100% PERSONALIZED PROGRESSIVE LENSES' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Presbyopia is a progressive loss of near vision that occurs in people after the age of 40. Presbyopia is caused by the irreversible, age-dependent weakening of the ciliary muscles that allow us to focus on objects that are close to us or far away. In presbyopia patients the eye lens loses its ability to round up to focus on near objects.Almost 2 billion people are affected by presbyopia all over the world. In Europe over 209 million people suffer it, 44% of the total population. Unfortunately, this percentage will keep increasing to reach 50% by 2030. From an economic perspective, only in the US the loss of productivity caused by presbyopia in 2011 amounted to $11B.Progressive lenses are the best solution to correct presbyopia because they provide clear vision at all distances. However, they need to be tailor-made, significantly increasing their price. Moreover, these lenses introduce distortions in the vision and require a long habituation time to be used comfortably. These flaws are intrinsic to the current methods of designing lenses, that do not consider optical and anatomical characteristics of every user; instead they estimate them using standard values.Lentitech, a start-up company funded in Spain, patented a solution to design 100% personalized progressive lenses. ErgoFocus is composed of a measuring device that takes measurements of the user’s facial and optical parameters, a software that interprets the data and a set of advanced algorithms that design progressive lenses based on these measurements. The Ergofocus design shortens the habituation time and minimize visual aberrations.Our product has a great opportunity of successful commercialization because the number of users of progressive lenses is increasing exponentially as the global population ages. As a