RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New processes for the fermentative production of glycolipid biosurfactants and sialylated carbohydrates' under Horizon 2020.

assistant: **Concept**

This project aims to develop new processes and solve bottlenecks in the fermentative production of biosurfactants and specialty carbohydrates. Specifically, the project targets the development of innovative fermentation processes to produce the following compounds:1.            Glycolipid biosurfactants. The project targets four distinct classes of biosurfactants, specifically rhamnolipids, sophorolipids, xylolipids and mannosylerythritol-lipids with a wide range of application fields.2.            Specialty carbohydrates. Specifically, the project targets sialylated oligosaccharides, a class of very complex Human Milk Oligosaccharides that find application as a neutraceutical, pharmaceutical and cosmetic ingredient. For both product lines, microbial producer strains will be developed through metabolic engineering. The fermentation process and down-stream processing will be developed and optimized in order to obtain an industrial process. Second generation technology based on lignocellulosic substrates will also be developed. Sufficient amounts of the new products will be produced for application testing, in order to evaluate their market potential in a wide range of application fields. The technical, economic, environmental and social sustainability of the process over the whole value chain from biomass to product application will also be assessed, with an emphasis on identifying and addressing the bottlenecks in the innovation chain. A valorisation plan will be drafted to complete the innovation process.The project consortium has all the required players to obtain the expected impact: RTO's to address the research challenges in this project, an open innovation pilot plant to optimize and scale up the new processes, three biotech SMEs and three large industries to ensu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Exemplar energy conscious European hospitals and health care buildings' under Fifth Framework.

assistant: **Concept**

The HOSPITALS initiative aims to demonstrate the significant reduction potential of the total energy demand in the European health care building sector.The objectives are:To implement and demonstrate innovative energy efficient designs when constructing 5 exemplar energy conscious health care buildings.To introduce the use of the Integrated Energy Design Process and the use of innovative renewable energy technologies.To obtain significant decreases of energy use, CO2 emissions and peak electricity demands.To ensure large improvements of the thermal and visual indoor climate for patients and employees, thereby achieving increased comfort, faster recovery of the patients and increased efficiency of the employees.To disseminate results and experiences to key decision makers, hospital managers, consultants and manufacturers.To stimulate that the use of energy efficient technologies will become standard measures for future building programmes set up by the European health care sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regulation of Expression of Staphylococcus aureus Vaccine Antigen Candidates' under Seventh Framework.

assistant: **Concept**

Staphylococcus aureus is a commensal of the human skin and nares, and a major cause of skin, and soft tissue as well as invasive infections. Bacterial pathogenicity results from a complex interplay of virulence factors with regulatory systems that respond to multiple external signals from the host environment and the bacterial population. Currently no vaccine against S. aureus is available. Novartis Vaccines and Diagnostics (NVD) has employed the reverse vaccinology approach to identify a list of novel antigens which are now under further analysis for inclusion in a vaccine. RESTAVAC will investigate the regulatory mechanisms involved in controlling expression of these vaccine antigen candidates. By analysing the temporal expression of novel antigens and characterised reference virulence factors, through reporter fusions, in various in vitro, ex vivo and animal models, RESTAVAC will uncover regulatory responses to environmental stimuli, diverse niches or disease settings as well as the molecular mechanisms involved in their fine-tuning. This will aid in predicting the efficacy of the candidate proteins as vaccine antigens and contribute to understanding their roles in the pathogenesis of the bacterium. Secondly, analysis of global gene expression profiles in ex vivo and animal models will greatly assist in identifying critical genes important for the different disease outcomes and the regulatory networks that may be involved. Such analysis will help to unravel the complex interactions between S. aureus and its host environmental niches during disease development. And thirdly, comparative analysis of reporter gene expression in both HA- and CA- isolates from geographic, temporal and sequence-type diverse origins along with genome-wide expression profiling will shed light
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Isopropenyl esters (iPEs) as building blocks for the synthesis and recycling of renewable polyethers with tunable properties' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The synthesis of novel monomers that combine a bio-origin, scalability, low cost, and structural modularity merged with the synthesis of custom-degradable plastics is one of the major objectives in sustainable development. Realization of these goals can contribute to a circular rather than a linear economy. Within this context, the IMPULSE project aims to develop novel strategies for the catalytic synthesis of renewable polyethers featuring tunable properties using isopropenyl esters (iPEs) as biobased and inexpensive precursors. The key polymerization strategy that is used entails ring-opening polymerization (ROP) through proper activation of iPE-derived oxides using Host-developed catalysts with known potential. The epoxide monomers are obtained through enzymatic epoxidation to streamline the green efforts of this research program. The main strengths of IMPULSE are the versatility of the starting precursors, the possibility of modulating the polyether structures and their properties before or after their synthesis, and the potential for degradation of the polyethers through controlled depolymerization, thereby creating a circular atom approach by repurposing the degradation products. The creation of a wider range of commercially attractive polyether macromolecules can boost a transition to biobased analogues with a significantly expanded application potential, and an increased tunability of the mechanical, thermal and optical properties while enabling an improved carbon footprint.


**Keywords:** Functional macromolecules, Chemical recycling, Ring-opening polymerization, Renewables, Catalysis, Epoxides, Sustainability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Non-gaussianities in the observable universe and the origin of cosmic inhomogeneities' in the context of a Seventh Framework call.

assistant: **Objectives**

Inflation provides a natural mechanism to account for the origin of cosmic structures. The generation of primordial inhomogeneities during inflation is usually computed as the result of the (gravitationally-induced) spontaneous creation of quanta from an initial vacuum state. However, as recently pointed out by Agullo and Parker, when the corresponding stimulated creation is considered, the characteristics of the state of the universe at the onset of inflation are not diluted by the inflationary expansion and can be imprinted in the distribution of primordial inhomogeneities. The objective of this research project is to provide a detailed analysis of the consequences of the stimulated creation effect during inflation.We will analyze the consequences of having a totally arbitrary initial state describing metric perturbations at the onset of inflation for the predictions of inflation regarding the Cosmic Microwave Background (CBM) anisotropies and galaxy distribution. We will pay special attention to the effects concerning non-gaussianites. This analysis will provide a characterization of the pattern expected from a generic non-vacuum state and, on the other hand, will show what information about that state can be extracted from observations.On the other hand, the stimulated creation effect opens a window towards the observation of pre-inflationary effects in the CMB and galaxy distribution. The objective of this part of the research project is to work out in detail the predictions arising from quantum gravity proposals of the early universe, and the potential that forthcoming observations have to constrain those proposals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Artificial Intelligence to Search for Drug Leads in Gigascale Chemical Spaces as a way to Fight Antimicrobial Resistance in Malaria' in the context of a Horizon Europe call.

assistant: **Objectives**

Malaria, a global infectious disease, is facing a critical issue of drug efficacy loss due to the alarming rise of antimicrobial resistance (AMR). To combat this, a promising strategy is the discovery of cell-active drug leads hitting new targets, such as P. falciparum dihydroorotate dehydrogenase (PfDHODH). However, two main roadblocks prevent us from achieving this important goal: 1) many molecules with potent activity on a protein target are later found to be inactive in pathogen cultures for various reasons, 2) identifying novel drug leads with potent activity on both protein and phenotypic targets has traditionally been a lengthy and costly process. A timely opportunity leveraging the fast-growing volumes of bioactivity and protein structure data to guide virtual screening. Indeed, Artificial intelligence (AI)-guided virtual screening has boosted hit rates and potencies in both molecular and phenotypic activity assays on other human pathogens. This multidisciplinary project will therefore investigate cutting-edge AI models to guide structure-based virtual screening against the molecular target PfDHODH. This project will use the best of these AI models to screen drug-like ultralarge libraries for novel molecules with potent activity on the considered target in a fast and cost-effective manner. To predict which of these target-active molecules are also cell-active, we will investigate and use AI models to guide phenotypic virtual screening against reference (Pf3D7) and drug-resistant (PfDd2) pathogen cultures.


**Keywords:** Antimicrobial resistant, malaria, virtual screening, conformal prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Education for Data Intensive Science to Open New science frontiers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The EDISON project will focus on activities to establish the new profession of ' Data Scientist', following the emergence of Data Science technologies (also referred to as Data Intensive or Big Data technologies) which changes the way research is done, how scientists think and how the research data are used and shared. This includes definition of the required skills, competences framework/profile, corresponding Body Of Knowledge and model curriculum. It wil develop a sustainability/business model to ensure a sustainable increase of Data Scientists, graduated from universities and trained by other professional education and training institutions in Europe. To achieve this, EDISON will work with the major Data Science stakeholders from academic, research communities and industry, as well as with the professional community to help them to obtain proper education and training and/or formal certification for already practicing self-made Data Scientists, grown from the advanced research projects who want to build a new career in Data Science.Consistent Data Science education and professional training requires besides theoretical knowledge access to real scientific data infrastructure and real large data sets to acquire practical experience and develop data centric  thinking. For this, EDISON will leverage on EGI infrastructure and community/activities, as well as products from the APARSEN project, to create a supporting infrastructure for Data Science education and training that will include both example datasets and virtual labs which will allow the students or trainees to work with real data sets, infrastructure and tools.EDISON will facilitate the establishment of a Data Science education and training infrastructure at major European universities by promoting experience of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Practical magnesium batteries enabled by 2D crystalline polymer-based artificial electrode skins', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The intrinsic limitation of Li-ion batteries (i.e., cost, safety, and sustainability) is imposing a strong demand for next-generation battery technologies based on resource-abundant elements. Among the top candidates for this purpose are Mg batteries. However, state-of-the-art Mg batteries still encounter numerous problems (e.g., low Coulombic efficiency, energy efficiency, energy density, and cycle life) and are far from mature to satisfy practical use. The disappointing performance of Mg batteries is dominantly assigned to the problematic interfacial charge transfer governed by the charge-dense Mg2+ at both the anodes and cathodes. Here, I propose the ground-breaking concept of using molecule-customisable 2D crystalline polymers (2DCPs) as artificial electrode skins to regulate the interfacial Mg2+ transport and enable practical Mg batteries. Relying on dynamic imine and sp2-carbon linkage reactions, ultrathin 2DCPs with varying porosity, dense nucleophilic groups, and stable polymer skeleton will be synthesised as the artificial electrode skins for Mg batteries. Multifunctional 2DCPs are expected to promote practically useful Mg anode stripping/plating chemistry and high-voltage/high-capacity cathode chemistries by forcing Mg2+ desolvation and Mg2+-anion dissociation, allowing fast and selective interfacial Mg2+ transport, and inhibiting the parasitic reactions associated with the electrolyte. An integrated approach combining atom-level structure investigation, Mg2+-transport study, and electrode chemistry evaluation will establish the molecular design principle for the optimal electrode skins. Ultimately, with artificial electrode skins, the prototype configurations for practical Mg batteries will be formulated, offering intellectual property for future battery prod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bio-informatics grid application for life science' to be submitted under Sixth Framework.

assistant: **Abstract**

In the BIOINFOGRID Specific Support Action (SSA) we propose combining Bioinformatics services and applications for molecular biology users with the Grid Infrastructure created by the EGEE Proposal (6th Framework Program). In the BIOINFOGRID initiative we plan to evaluate genomics, transcriptomics, proteomics and molecular dynamics applications studies based on GRID technology.The BIOINFOGRID SSA will establish a common ground for collaboration between the European Grid Infrastructure providers and the Bioinformatics research user community in various fields of Bioinformatics applications (Biology, Computational Chemistry, Medicine and Biotechnology). This will be achieved through specific studies for each reference application in the Bioinformatics domain in which experts of various disciplines can collaborate on the solution of highly complex problems.The programme covers the most contemporary uncharted fields of investigation in biological and medical research. The project will support studies on applications for distributed laboratory management systems for micro-array technology, for gene expression studies, for gene data mining, for analysis of cDNA data, for Phylogenetics analysis, for distributed database access, for protein functional analysis and for molecular dynamics simulations in GRID. A new challenge of the Wide In Silico Docking on Malaria and an international conference for GRID Bioinformatics applications will be organized by the BIOFOGRID project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The next generation of sensors and imagers enabled by 2D materials digital integration' (Next-2Digits), addressing dissemination and exploitation.

assistant: **Impact**

Graphene and 2D materials (2DM) have proven superior optoelectronic properties and performance in a plethora of applications with respect to conventional materials. Despite that, specific integration and processing challenges are impeding the industrial uptake of 2DM. In particular, the wafer-scale integration of high-quality and defect free 2DM layers, without disrupting the process-line Si foundries, has not been demonstrated. Next-2Digits will introduce the direct wafer-scale integration of 2DM in PICs using two additive technologies: i) semi dry transfer of Graphene layers for full wafer scale integration and direct die processing and ii) Laser Digital Transfer of pristine 2DM pixels directly on the stack without the need for post-processing. This will enable defect-free interfaces offering high carrier mobility and large bandwidth, paving the way for the next generation of on-chip Photodetectors (PDs) and Modulators which will be validated at TRL5 in three use cases:1. A miniaturized LiDAR with integrated graphene PD offering high resolution (<0.1mm) and high speed in compact form factor validated in an UAV mapping system. 2. A PIC gas sensor with sensitivity down to 50ppm and miniaturized footprint offering multi-sensing capability validated in a biogas plant leakage sensing system.3. An on-chip PD receiver offering extended bandwidth (>100nm),  high resolution  and responsivity >0.5A/W validated in a biomedical OCT imaging system. The project will foster the incorporation of 2DM in PICs and MEMS foundries, enabling future industrial uptake and significantly shorter time-to-market for 2DM-based devices.  Companies will be able to offer PIC-based components with (up to 6x times) lower power consumption, lower size (in orders of magnitude) and more than 50% reduced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INVI self-defense bracelet: feel empowered' (INVI) under Horizon 2020.

assistant: **Objectives**

Sexual violence remains an important social issue both in developed and developing countries worldwide. Although more and more attention is devoted to this violation of human dignity, and gender equality and women's empowerment are at the top of the agendas of the European Union and United Nations, the number of sexual assault victims is still alarming. Even though the problem is not restricted to a special segment of the society, women represent the majority of victims. We at INVI are convinced that awareness, self-confidence, and education represent the main instruments to tackle this unresolved issue. We aim to deploy in the market the INVI Bracelet: an innovative, patented, non-violent self-defense wearable device, that enables the users to protect themselves and empowers women and men by making them feel safer in their daily lives. The mechanism is simple; in case of emergency, the wearer can activate the safeguard of the bracelet, the capsule breaks and releases an unpleasant and repellent smell which confuses, distracts, and sexually discourages the potential attacker; it can also alarm people in the vicinity since it is perceptible for over 100 meters. Our prototype has been tested and validated with end users in collaboration with the City of Rotterdam and so far 600 bracelets have been sold. Now, we aim to get to an optimized mass manufacturing process, develop a new low-cost version for the developing countries, and reach up to 1 million women by 2020. In addition to protect the potential victims of sexual harassment, we also aim at creating a community of people wearing the Bracelet to speak out against violence, and support gender equality. The performance of this feasibility study will help us minimise the technical, commercial and financial risks before u