RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanoplastic Transport in Groundwater environments' (NaplaGro).

assistant: **Concept**

Groundwater is the largest drinking water resource on earth and 75% of EU residents depend on groundwater as water supply . Plastic contamination of drinking water supply wells has recently been documented. Plastic particles are a vector for pollutants ; interfere with biogeochemical cycles and nutrient transport , while particular nanoplastic (NP) is shown to cause adverse effects on human health. Hence, drinking water contamination by NP is a serious threat to human health. To protect the Earths largest freshwater reservoir and guarantee a sustainable use of water resources within Europe for future generations, we need to understand NP behavior in groundwater aquifers. In this MSC-action, I will study the transport behavior of NP particles in complex mineral and biogeochemical groundwater settings from lab- to field scale in order to embrace the natural complexity of aquifers. The following MSCA objectives address four major knowledge gaps of NP transport in groundwater systems:  i)How does NP shape affect transport in groundwater? ii)Can flow rates modify NP transport in complex mineral and biogeochemical porous media settings?iii)Are fungal communities able to retain NP under realistic aquifer conditions? iv)Can findings from laboratory studies be up-scaled to field scale studies?    I will answer these objectives by conducting laboratory experiments combining nanotechnological methods with novel microfluidic chips as well as field scale experiments using a tracer injection method. With these approaches, we generate tracer breakthrough curves inferring sediment specific retention rates, while they also enable us to gain better mechanistic understanding of NP transpor in porous media.  This MSCA will be a stepping-stone in understanding NP transport in groundwater en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NON-FOOD AGRO-INDUSTRIAL RESEARCH INFORMATION DISSEMINATION (NF-AIRID) THROUGH PAPER AND ELECTRONIC MEANS' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This proposal seeks support for the continuation of an on-going concerted actionfunded for two years under the AIR programme (project AIR3-CT94-2299) with theobjective of disseminating the results of European Commission (EC) researchprojects in the area of non-food use of agricultural raw materials.This project will collect and collate lnformation relevant to the non-food agro-industrial research anddemonstration activities supported by the (EC) as well as that from other sourcesand disseminate this information to a target audience (those to whom it would beof particular benefit, especially SMEs) through a network of National NetworkLeaders established in the Member States. This activity will continue to bring theresults of such projects from the AIR and FAIR programmes to the attention ofpotential users as well as attract new participants to future programmes (FifthFramework) help avoid duplication between national funded work and EC fundedactivities, as well as help identify areas where research is needed and providefeedback to the Commission concerning the types of organisations involved in nonfood and their activities and interests in terms of raw materials used or required,products of present or potential market value and technologies used. Disseminationwill be both by post and fax (paper) and through the InterNet, by establishing adedicated web-page on the World Wide Web (WWW), and by periodic issue ofup-dated databases on CD-ROMs. A kick-off meeting and a number of workshopscovering specific issues will be organised. One of the key objectives is to evaluate the relative merit of the alternativedissemination routes: postal, fax, e-mail, web site, CD-ROM. This evaluation wouldbe carried out to define the cost/benefits of these methods as well as to establishthe rat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular organization of the human Centromere' under Sixth Framework.

assistant: **Concept**

Cells need to inherit their chromosomes accurately. Errors in segregation cause aberrant chromosomal composition and thus disease. The centromere, a discrete locus on each chromosome, is vital in this process, but its composition and structure remain largely unknown. How does a cell know where to form a centromere? What is the architecture of this large molecular assembly? Molecular and genomic studies of the centromere have been hampered by the occurrence of repetitive a-satellite DNA on which centromeres normally form.This problem does not exist in neocentromeric cell lines which contain additional chromosomes that lack a-satellite DNA. This implies that epigenetic modifications such as histone methylation may determine centromere identity. Neocentromeres are thus an excellent model to identify what determines centromere identity. We will generate high-resolution genomic microarrays (CHIPs) covering neocentromeric regions. Using chromatinimmunoprecipitations (ChIP), we will produce a map of centromeric components and epigenetic modifiers at a resolution closeto that of individual nucleosomes. We will use RNA interference assays to alter the protein levels of key centromeredeterminants, which will allow us to probe the hierarchical organization of centromere assembl y, and use the CHIPs to detect novel RNA transcripts from the centromeric regions.There is no epigenetic map and no insight into the molecular organization of a human centromere. Our novel project may finally get at these important questions. Our results have implications for the design of novel anticancer drugs through the targeting of centromeres (rather than microtubules), and for generating shuttle vectors for livestock and crop engineering, as well as human gene therapy. Further, we will establish nove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification and Genetic Profile Characterization of Lgr5 positive Colon Cancer Stem Cells' (2007-2013).

assistant: **Concept**

In the murine small intestine, the epithelium renews every five days. This vigorous self- renewing process is controlled by several secreted Wnt factors at the base of the crypt-villus axis. Lgr5/Gpr49 gene is a Wnt target gene that displays a complex expression pattern during embryogenesis, yet expression in most tissues subsides around birth. In adult mice, Lgr5 expression is restricted to rare, scattered cells in multiple tissues including the hair follicles, mammary glands and the intestinal epithelium. In the intestinal epithelium, Lgr5 is expressed throughout the proliferative crypt compartment and has been recently identified as a marker of adult stem cells in small intestine and colon. The cancer stem cell hypothesis postulates that a small reservoir of self-sustaining cells is exclusively able to self-renew and generate the heterogeneous cell population that constitutes the bulk of the tumour. Importantly, Cancer Stem Cells (CSC) not only fuel tumour growth but also tumor metastases. In 2002, Lgr5 was identified as a gene expressed in colon cancer. Therefore, the main goal of this project is to identify colon Cancer Stem Cells by using Lgr5 as a marker and compare the expression profile of this CSC cells with normal adult intestinal Stem Cells. First, I propose to analyse the Lgr5 expression pattern in tumours deriving from the intestinal tract, and compare it with the appropriate non-tumor controls. Following, Lgr5 positive cells will be isolated from fresh tumour suspensions, by antibody-based FACS sorting, and tested for Cancer Stem cell potential. Finally, the expression profile of Lgr5 positive colon Cancer Stem Cells will be compared with the genetic profile of Lgr5 normal intestinal Stem cells, to identify the genes implicated in Stem Cell malignant tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Sustainable fertigation techniques for vegetable production in Greece'.

assistant: **Objectives**

Vegetable production constitutes one of the most important farming activities in Greece and has the potential to develop further. However optimal levels of vegetable production require high water inputs, especially under Mediterranean conditions. Fertigation (which means the combination of fertilisation and irrigation) is a tool for analysing and achieving optimal levels of water and fertiliser use.A system has been developed by PPO (Applied Plant Research - Division Glass; part of the Wageningen-University - Research, the Netherlands) in the sixties and has been constantly evolving since then. Soilis analysed by a 1:2 volume water extract. Based on this salt and nutrient analysis, fertiliser and irrigation are advised to the growers. In total about 5000 growers, both in theNetherlands and abroad are using the system. New elements have to be introduced into this system to make it appropriate for the Mediterranean situation. The work plan consists of evaluation of the Greek situation, workshops, contacts with laboratories agricultural universities, agricultural extension services, growers association, on-farm demonstrations, trials and introducing the system into a (private) laboratories and extension services.An experienced researcher of NAGREF will be trained at PP Oduring 3 months. A more experienced researcher of PPO will be hosted by NAGREF during 10 months and will provide training to partner organisations. The project management structure will consist of a Project Committee and a Project Management Team.The Project Committee will be include these two researchers together with: the director of NAGREF, the director of Olive and Horticultural Crops at the Institute of Kalamata, a representative of an agricultural educational institutes, of (one or more) private labor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'An innovative & seamless approach for the mass spectrometry analysis of monoclonal antibodies'.

assistant: **Concept**

Therapeutic monoclonal antibodies (mAbs) are innovative therapeutic tools that are currently drawing the attention of biopharma companies for their effectiveness against a broad panel of diseases.  To guarantee safety for patients, tight control over the purity of mAbs preparations is crucial. The presence of contaminants in mAbs preparations can be assessed using mass spectrometry (MS), a technique characterised by remarkable sensitivity, but which requires a time-consuming, complicated and poorly reproducible sample preparation. Notably, at today’s date, this process cannot be automated or multiplexed: it has to be performed by highly skilled scientific staff, and - importantly - it cannot be easily “plugged in” the streamlined production approaches of pharma companies. PreOmics is a young German company seeking to revolutionise the MS proteomics market with its proprietary technology portfolio. Through the iSTantibody project, PreOmics translates its patented iST technology in the context of mAbs MS analysis and tackles the current pitfalls of mAbs sample preparation. Its final goal consists of a kit to simplify and shorten MS sample preparation by > 95% compared to standard protocols, eliminating the need for skilled scientists and allowing MS sample purification on automated liquid handling platforms. The advantages for potential customers are manifold – notably, significantly reduced costs, and the consequent possibility to free resources for mAbs development. The target sector of iSTantibody is the ever-growing market for MS sample preparation consumables, which is forecasted to reach a volume of € 1.3 billion worldwide in 2022, at a CAGR of 12%. The benefit of the iSTantibody project will produce remarkable benefits for PreOmics, both in terms of increased reven
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Advanced test beds for effective quality control of industrial high-temperature superconductors.'.

assistant: **Concept**

ObjectivesThe primary objective of the project is to develop advanced measurement tools which the European industry and collaborating research institutes need to control the quality and essential transport properties of technical high temperature superconducors (HTS). The main goal is to develop new, and partly modify, laboratory characterisation techniques for quality measurements and pre-normative research on technical superconductors. State of progressThe development of new measuring methods and testbeds proceeds as planned. Both measuring methods for the in-process maximum current measurements are accurately compared. The prototype of testbed for the transport properties is applied in a production environment and has characterised more than 5 km of conductor. A new AC-loss testbed for tapes is developed and tested. The first parametric study of the AC-loss in a tape conductor is performed. Two methods of testing the power loss in a full-scale cable model, based on calorimetric and electrical measuring methods, are compared and found to be in good agreement. Finally a first report on the measuring techniques is prepared and sent to the relevant standardisation body (CENELEC)BackgroundThe development of high temperature superconductors for power applications is focussed on the ceramic compound Bi2Sr2Ca2Cu3Ox (Bi2223) operated at 77 kelvin. The ultimate performance of superconductors is presently controlled with benchmark tests on pieces cut from the conductor production. This means that the piece of conductor supplied to the customer is not checked on its relevant superconducting properties. The relatively high price per unit length and the complicated quality characteristics forces to commence the development of new tools for in-process performance testing and standa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Replacement and Original Magnet Engineering Options' (ROMEO).

assistant: **Innovation**

Permanent magnets are vital components in an enormous number of domestic and industrial devices, and they are particularly crucial within the rapidly-developing renewable energy sector, where the motors for electric vehicles and the generators in wind turbines require strong magnets with the ability to operate at temperatures well over 100°C. Currently, these magnets are based on the rare earth elements neodymium and dysprosium, which are predominantly mined in China (>95%). Exports are being restricting as a result of an expanding domestic market and a policy of relocating magnet manufacturing to China, thereby multiplying the costs of raw materials for magnet manufacturers in Europe. The rare-earth crisis is particularly critical for heavy rare earths such as dysprosium that are currently required to assure the high temperature performance of the magnets. In accordance with EU objectives to remove, or greatly reduce, the need for heavy rare earths in permanent magnets, ROMEO will first research and develop several novel microstructural-engineering strategies that will dramatically improve the properties of magnets based purely on light rare earths elements, especially the coercivity, which will enable them to be used for applications above 100°C. ROMEO’s second ambitious goal is to develop a totally rare-earth-free magnet; aiming to drastically reduce Europe’s dependence on Chinese imports while shifting emphasis in magnet manufacturing from a raw-materials-dependent business to one that is essentially knowledge-based, and flourishing in Europe. The ROMEO consortium assembles the best European academic expertise in permanent magnetism together with world-leading magnet manufacturers and European companies who are eager to exploit these newly developed materials, espec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European and Chinese Cooperation on Grid' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

ECHOGRID will foster collaboration in Grid research and technologies by defining short, mid, and long-term vision in the field. <br/><br/>The project will:<br/>- develop a collaboration roadmap that identifies common areas of interest and opportunities for collaboration on Grid technologies between the EU and China;<br/>- consolidate this vision and promote cross-fertilisation between Grid-related projects and initiatives in Europe and China by interacting with the GRID research and industrial communities;<br/>- exchange experiences and best practices by selecting Grid Open Standards for Grid middleware and applications interoperability and by promoting the identification of guidelines for building a Standard Quality Assurance Process;<br/>- support lasting cooperation and establish tangible partnerships in the field through support activities and tools, ranging from a mobility programme to a dedicated partner profile database.<br/><br/>The project will organise a set of workshops on strategic topics defined by a group of experts open to researchers and engineers from both academia and industry to define a better view of the research and development activities both in China and Europe. The mobility programme will be set up to encourage exchange of personnel across countries and institutions. <br/><br/>The major outcomes are:<br/>- 3, 5 and 10 years roadmaps developing a shared European and Chinese vision of future GRID research perspectives for both research and industrial communities. This vision will establish a clear Technological and Research Agenda on which both sides may collaborate;<br/>- a series of conferences and workshops open to both European & Chinese participants from research, industry, government, SMEs and user communities;<br/>- a EU-China Interoperabil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Individualised and Equitable Care of Type 2 Diabetes' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

EASY – Diabetes is a digital health solution that helps patients with Type 2 diabetes and health care providers analyse dataand make better decisions about therapies by accessing a carefully curated global database based on clinical data andmedical evidence collected over the course of nine years and powered by machine learning algorithms and other forms ofartificial intelligence. We offer EASY-Diabetes as a Software-as-a-Service to healthcare providers at a fee of €50 per patientper year.Diabetes is a prevalent and costly chronic disease, affecting 425 million people worldwide. Although 9.2% of the health carebudget in Europe spent on diabetes, the results for patients remain inadequate even in the most advanced healthcaresystems. Patients lack a patient-centred and personalised approach to disease management. 90% of patients with T2D aretreated by GPs in primary care. Most clinics lack both the manpower and the expertise required to deal with the needs ofpatients for regular contact with health care providers and the complexity of diabetes treatment. Existing eHealth solutionsshow some crucial drawbacks, such as lack of clinical validation against the standard of care, no personalised medicaltreatment options, not being drug agnostic.Our team brings together demonstrated expertise in medicine, clinical trials, drug development, regulatory affairs, productdevelopment, programming, machine learning, business development.The SME Phase 1 Feasibility study will aim to complete the validation of the commercial feasibility of Easy – Diabetes withtarget market segments and key stakeholders. We will strengthen our financial planning and IP protection strategynecessary to improve our service and refine our go-to-market strategy.