RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dark matter and neutrino experiment with monolithic arrays of cryogenic detectors' under Horizon Europe.

assistant: **Concept**

In Particle Physics the research on neutrinos is continuously producing new results and further discoveries might just be around the corner. They could provide answers to crucial questions on how matter was created in the Universe or reveal the existence of new types of fundamental interactions between elementary particles. Possibly even more intriguing is the search for Dark Matter, an unknown form of matter that, according to astrophysical observations, outweighs the ordinary matter in our Universe by more than 5 times. Dark Matter particles have been searched for since 30 years, and invariably eluded discovery. DANAE intends to enable unprecedented sensitivities in the study low energy neutrinos and in the search for Dark Matter, by measuring the tiny nuclear recoils that these particles induce in their passage through matter. The goal is to create a pilot experiment by introducing for the first time monolithic, and at the same time highly segmented, arrays of thousands multiplexed superconducting detectors. If successful, precision measurements of a recently discovered process, the coherent and elastic neutrino scattering off nuclei, could be made. In the Dark Matter field new hypothesized particles could be sensed, lighter than those searched and never found so far.


**Keywords:** Neutrinos, Dark Matter, Cryogenic Detectors, Kinetic Inductance Detectors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Tracking the dispersal of Homo sapiens into the Levant and across wider Eurasia' (Disperse) under Horizon Europe.

assistant: **Objectives**

The diaspora of modern humans from Africa into Eurasia and beyond is one of the seminal chapters in the history of our species. Modern humans emerged in Africa by 250-300,000 years ago. Their several subsequent dispersals outwards must have followed one of two routes, the most likely being across the Sinai Peninsula and Levantine corridor. Here, they would have encountered resident Neanderthals and beyond, into Eurasia, the Denisovans. A major dispersal of modern humans by ~50,000 years ago, hypothesised to be linked with the Initial Upper Palaeolithic, is paralleled by further development of aspects of behavioural modernity; the increased presence of symbolic objects, art, new types of technology and the ability to adapt and survive in novel and challenging environments. The Lebanese site of Ksar Akil is the ‘type site’ for the Palaeolithic in the key Levant region. First excavated in the 1930s/40s, and again in the 1970s, it contains a deep ~23m sequence. Sadly, despite its importance, its potential has never been realised, but is clear that it can contribute greatly to our understanding of human presence, climate and environmental changes over the last ~90,000 years. This project plans to reveal this by applying the latest sediment DNA approaches to determine the presence of different hominins through the archaeological sequence, dating the site reliably for the first time, analysing its stone tool remains and generating a paleoenvironmental and climatic history. In parallel we will collate new and unpublished data from a range of similar Palaeolithic sites from across Eurasia, to test hypotheses concerning the movement of early human groups into and out of the region. The project will contribute a strong legacy value, for local Lebanese archaeology and students, as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Epigenetic regulation of host factors in viral infections (EPIVINF)' (EPIVINF) targeting Horizon Europe.

assistant: **Abstract**

The EPIVINF project aims to gain a deep understanding of how acute viral infections alter the epigenetic regulation of host factors that are critical for immune control and neurological health.  In particular, EPIVINF will address how acute viral infections impact epigenetic control of host proteins that drive virus-associated disease and/or are involved in the antiviral immune response and how such persistent, epigenetic marks are related to long-term disease evolution. EPIVINF will focus on two major human viral infections, HIV and SARS-CoV-2, both pathogens that affect millions of people around the world and which, despite well-known differences, share some intriguing features that demand further research. We hypothesize that a) defining individuals personal epigenetic profiles, b) assessing how they impact on the innate and adaptive immunity and c) analysing epigenetic control mechanisms in two different viral infections (HIV and SARS-CoV-2), will provide important insights into how different individuals react to different viral infections, how different infections may share similar mechanism that impact on the long term health outcomes, how these processes define the further disease course and, finally, how they could serve as targets for novel therapeutic interventions.To achieve these goals, we will use an panel of cutting-edge epigenetic analyses, immune monitoring tools, disease-relevant animal models, samples from unique human vaccine trials and integrated biosystems analyses to gain a deep understanding of how viral infections harness epigenetic mechanisms to change the adaptive and innate immune phenotype of infected individuals, not only during acute stages of the infection but potentially for live. The study includes extensive patient follow-up to identify
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Respiratory Precision Medicine PhD Training Network- Excellence through Systems Biology, Spatial and Single-cell Transcriptomics' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Asthma and COPD are prevalent, chronic respiratory diseases, with high incidence and societal costs. Current treatment is based on a ‘one-size-fits-all’ approach, that suppresses symptoms, but fails to achieve stable remission of disease. There is an urgent need to replace these generic treatments with precision medicine for asthma and COPD. This transition is hampered by the complexity of asthma and COPD on the one hand, and by the lack of an integrated, multidisciplinary approach to achieve progress towards precision medicine for these chronic respiratory disorders on the other hand. The complexity of asthma and COPD is caused by multiple molecular mechanisms that independently contribute to the pathogenesis of disease. Their activity varies over time, and between patients, leading to substantial heterogeneity of asthma and COPD: identical clinical phenotypes can be caused by dissimilar molecular and cellular mechanisms, and requiring different treatments. The vision of RESPIRE-EXCEL is to achieve the transition to precision medicine in asthma and COPD by cross-sectoral and multi-disciplinary collaboration in respiratory research, drug discovery and development. The success of this approach depends on respiratory scientists with the competence to combine expertise across disciplines, and the skills to collaborate with experts from industry, healthcare and academia. Therefore, the goal of RESPIRE-EXCEL is to enable the transition to precision medicine for asthma and COPD by training the next generation of translational and physician scientists with the skills, cross-sectoral competences and multidisciplinary knowledge to identify the molecular mechanisms of asthma and COPD, develop improved prognostic and diagnostic biomarkers to detect their activity in individual pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Miniaturized and reconfigurable instrumentation for multipurpose survey with a mini autonomous vehicle: Development and validation at sea' (MAUVE).

assistant: **Innovation**

Instrumented mobile unmanned platforms are a promising alternative to current undersea measurement methods, being able to conduct fast 3-Dimensional survey in highly variable environment, such as coastal areas. Such measurements acquire a growing importance for the construction and validation of oceanographic models. However these instrumented vehicles will be economically viable only if they really offer affordable elementary data acquisition and simple exploitation and support means. The overall objective of the MAUVE project is to develop and validate at sea a miniaturized, reconfigurable, mobile and autonomous Instrumentation, dedicated to Multipurpose Survey, in particular in coastal waters. It will be characterized by coherent integration of a compact automatic multiparameter measurement module with a very small Autonomous Underwater vehicle. enabling sensor-driven navigation. This project is expected to offer:  - low cost baseline, with multi-instrument capability  - easy maintenability and fast new-mission reconfiguration  - low risk mission achievement and reliable homing function  - single person handling, from a small ship or from the shore - multi-vehicle configuration capability Such a demonstrator, derived from an existing vehicle (CALAS), will be developed and validated at sea, in two different eumpean coastal marine environments: a front delimitation" mission will be performed in North-sea, and an automatic mapping of bottom characteristics in the mediterranean sea. Surveying the water column should involve reliable and accurate measurement of temperature, salinity turbidity, fluorescence and nutrients. Extra-sampling capabilities will be investigated, both for re-calibration of sensors and for further detailed analysis. Automatic mapping of bottom chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'OTIMISED USE OF RURAL ELECTRIFICATION BASED ON PHOTOVOLTAICS'.

assistant: **Concept**

This project is an integrated project with three components : energy production using solar photovoltaics (PV) systems, energy production using wind technology and distribution through a consumer interactive grip applying demand-side management concepts, with similar quality to conventional grid. The wind Generator is part of another Thermie project co-ordinated by Vergnet, having CCE, EDP and Ourique municipality as partners. The distribution grid will be financed by the partners and national funds. Within this contract, the Thermie programme will only support the PV component. The overall-project aims to :Provide with electric energy supplied by these units will be used for domestic purposes, irrigation of the 50ha of surrounding area and public lighting. Also 20 abandonned dwellings could be supplied with energy and used for tourism purposes, as is intended by the municipality. Santana da Serra is the most southern Parish of the council of Ourique-Alentejo, and it borders the municipality of Silves, in the region of Algarve. It is composed by several isolated settlements with an elderly population. Many settlements in the distant farms are deprived of electricity. These settelments have a 6 km distances from the nearest electrified area. The solar energy available for Faro (50 km distance) is 5.1 kWh/m?*Y on horizontal plane. The economic activity of the people living in these settlements is almost exclusively conneted with the agriculture for their personal use and the breading of domestic animals.The lack of electric energy has consequently the lack of water and an increase of the difficulties, and therefore the abandonment of the local settlements. With the arrival of the electric energy there will be changes, such as : - drinking water supplying for people and an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural investigation of interplay between epigenetics, transcriptional regulation and DNA damage' (EPIDNA), addressing dissemination and exploitation.

assistant: **Impact**

In eukaryotic cells, gene expression is regulated by a complex interplay between a number of factors, from large-scale chromatin accessibility to inducible enhancers or repressors to local DNA modifications, changes in nucleosome architecture and specific histone markers. These finely tuned factors coordinate embrional development, response to stimuli and changes in cell fate. At the same time, this regulatory network has to robustly accommodate random events, most notably the presence of DNA damage and the action of DNA repair factors. While recent reports suggest this interplay is not always smooth, our mechanistic understanding of the underlying processes is severely limited, highlighting the need for quantitative approaches that will yield predictive models.In this proposal, I plan to investigate three aspects of this interplay that recently came into the spotlight. Firstly, an integrative computational and experimental approach will be used to quantify the positioning effect resulting from a range of common DNA modifications: regulatory base variants that can be used to enforce specific nucleosome patterns, and damage byproducts that would thereby interfere with DNA repair through altered exposure to the environment. Secondly, a number of transcription factors will be systematically assessed to detect ones sensitive to the presence of the most common oxidative lesion, 8-oxoguanine, to identify possible direct cross-talk between oxidative stress and transcriptional regulation at oxidative hot spots. Finally, a multiscale quantum/classical study will explore the thermodynamics, mechanism of formation and possible nucleosomal locations of covalent histone-DNA cross-links that were recently postulated to both mediate the regulatory role of 5-formylcytosine and accelera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GUT VIrus BRain Axis Technology In OrgaNoid Science' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The battle against infectious diseases is hampered by lack of therapeutic innovations due to poor understanding of disease outcome in humans. Organoid technology is a major breakthrough for medical research that has traditionally relied heavily on animal models. In our current OrganoVIR consortium, we are at the forefront in establishing human organoids as superior models for viral pathogenesis and antiviral research. The next critical step is to integrate organoid models to create a complex multi-organ ex vivo model that better mimics the human physiology. This raises several challenges such as incorporation of various cell types, medium incompatibility, validation, high throughput, and robust ways to connect mature organoid models. At the same time, the model has to be accessible, user friendly, and affordable to all end users. Therefore, this proposed GUTVIBRATIONS consortium will leverage its expertise in microfabrication, organoid technology, virology, immunology, bioengineering, and materials science to deliver an enabling organ-on-chip system.As a demonstrator, a modular human gut-brain axis multi-organ model will be achieved for studying viral disease and treatment. This model will be built by combining an open source 3D printed scaffold technology with human gut and brain organoid models. The deliverables will include a complex gut epithelial layer, immune cell layer, blood-brain layer and brain organoid; all individually developed and subsequently connected by vertical stacking. Our unique modular approach where individual components are separately developed and validated minimizes compatibility issues. The individual models and the multi-organ model will be used for studying three different clinically relevant viral infections with high global burden and will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bridging Gaps Between R2I in Resource Efficiency and Raw Materials' to be submitted under Seventh Framework.

assistant: **Abstract**

RERAM responds to the societal challenge of ‘CLIMATE CHANGE, RESOURCE EFFICIENCY AND RAW MATERIALS’ in Europe’s forestry and woodworking sector. Knowledge, communication and cooperation gaps between research communities and innovation-driven industries significantly hamper progress towards sustainable use of the natural resource FOREST in the woodworking sector. The RERAM project targets the very low resource efficiency rate of the wood processing business in ENP Eastern Countries. The 12 partner consortium builds upon their previous collaboration between forerunner regions in Germany (NRW), Austria (Styria) and Ukraine (Carpathia), and reaches out to complementary R2I actors in neighbouring ENP countries Moldavia and Georgia, and Poland, and further beyond. RERAM will bridge the gaps in the forest and wood sector’s research to innovation chain to unlock significant saving potentials of raw materials and wastes in woodworking SMEs, and to seize a major opportunity of improving green production and climate change mitigation in these emerging hotspot forest regions. By raising awareness on gains from higher efficiency, and by offering targeted benchmarking, hands-on best practices, information on best available techniques as well as training and coaching measures to entrepreneurs and intermediaries involved in RTI support, the project will enhance competitive capacities of the regions for future joint actions under Horizon 2020. By means of its dissemination channels and joint activities, RERAM builds interfaces to various existing collaborative actions and platforms, promoting cross-organizational and cross-regional dialogues, distilling complementarities, supporting a stronger intertwining of compatible regions and actors, and aligning mutual R2I strategies for increase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Balancing clean Water and Energy provision under changing climate and eXtremes'.

assistant: **Innovation**

Providing clean water and energy simultaneously to a growing global population and under a changing climate is a major challenge. The demand for the two and their systemic interdependencies are particularly strong during droughts and heatwaves. Despite the recent growth in water-energy nexus studies, there is little fundamental understanding of the cascading effects and feedbacks between water and energy systems during extreme weather events. Because existing global model approaches mainly focus on whole-system optimisation and are based on coarse spatiotemporal water and energy system representations, we lack understanding on how water-energy system processes cascade in time and space under a changing climate and extremes. Yet such understanding is urgently needed so that we can balance clean water and energy provision in our changing world in which climate shocks are increasing.In B-WEX, I will develop spatially explicit pathways that reveal how the provision of clean water and energy can be balanced under various water management and energy transition developments, including the feedbacks and cascading mechanisms under present to future droughts and heatwaves in regions worldwide.With my team, I will build a novel global framework which will be the first to integrate high spatiotemporal resolution models of hydrology, water quality, water use and energy systems to estimate how water and energy system processes cascade in time and space. Together with key actors, we will also develop quantitative water management and energy transition (climate action) pathways, which we will then combine with our new framework, enabling us to estimate trade-offs between water and energy systems during present to future droughts and heatwaves. The B-WEX project will greatly deepen our