RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering adaptive footprints of epiC evolution on different timescales' (DECAF).

assistant: **Innovation**

Epigenetics plays a fundamental role in the function and regulation of the genome. From an evolutionary viewpoint, a pressing question is whether epigenetic modifications are a source of adaptive variation. To answer this question substantial attention is being given to the epigenetic marks themselves, but surprisingly little is known about the evolutionary underpinnings of the genomic sites that anchor them. Using novel analytical and technical approaches, I want to address this fundamental knowledge gap. I will use the best understood epigenetic mark, DNA methylation, as a model and  advance on recent findings in avian genome evolution, epigenetic inheritance and sequencing technology. This will enable me to pinpoint signatures of epigenetically driven adaptation. I have designed separate approaches at three different levels: (1) At the individual level, to identify stably methylated anchors in the avian germline with focus on a recently discovered germline-specific chromosome, (2) at the population level, to establish the selective forces acting on DNA methylation diversity in natural populations and (3) at the species level, to gain insight into how fast-mutating anchors of DNA methylation act as potential facilitators of species differentiation and barriers. Ultimately, by combining these three levels I will be able to pinpoint epigenetic anchors that are involved in molecular adaptation. The possible research outcomes will not only be valuable to evolutionary biologists and ecologists, but will also make fundamental contributions to molecular biology and possibly medical research, and will deepen our understanding of how epigenetic marks manifest themselves at the sequence level.


**Keywords:** adaptive evolution, DNA methylation, speciation, gene-flow, mutation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fatty acid incorporation and modification in cyanobacterial natural products' under Horizon 2020.

assistant: **Concept**

Known, but mostly novel natural products (NPs) are in high demand – these are used in drugs, cosmetics and agrochemicals and serve also as research tools to probe biological systems. NP structures inspire chemists to develop new syntheses, and NP biosynthetic enzymes add to the metabolic engineer’s toolbox. The advent of next generation DNA-sequencing has revealed a vastly rich pool of NP biosynthetic gene clusters (BGCs) among bacterial genomes, most of which with no corresponding NP. Hence, opportunities abound for the discovery of new chemistry and enzymology that has the potential to push the boundaries of chemical space and enzymatic reactivity. Still, we cannot reliably predict chemistry from BGCs with unusual organization or encoding unknown functionalities, and, for molecules of unorthodox architecture, it is difficult to anticipate how their BGCs are organized. It is the valuable, truly novel chemistry and biochemistry that lies on these unexplored connections, that we aim to reveal with this proposal. To achieve it, we will work with a chemically-talented group of organisms – cyanobacteria, and with a specific structural class – fatty acids (FAs) – that is metabolized in a quite peculiar fashion by these organisms, paving the way for NP and enzyme discovery. On one hand, we will exploit the unique FA metabolism of cyanobacteria to develop a feeding strategy that will quickly reveal unprecedented FA-incorporating NPs. On the other, we will scrutinize the intriguing biosynthesis of three unique classes of metabolites that we have isolated recently and that incorporate and modify FA-moieties. We will find the BGCs for these compounds and dissect the functionality involved in such puzzling modifications to uncover important underlying enzymatic chemistry. This pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Healthy lifespan inequality:  Measurement, trends and determinants' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite its widespread use and popularity, life expectancy (LE) has two shortcomings. First, its definition only takes into consideration mortality levels, thus ignoring the health status of those who remain alive. Second, LE is an average that does not explain how length of life is distributed across the population. These limitations have generated two strands of research (i.e. the study of ‘health expectancies’ (HE) and ‘lifespan inequality’ (LI)) that, so far, have developed independently from each other. The overarching objective of the HEALIN project is to bring together these research avenues into a coherent whole to get a more comprehensive understanding of contemporary population health dynamics. To attain this goal, I put forward the new concept of ‘healthy lifespan inequality’ (HLI), which is designed to investigate the extent to which healthy lifespans are unequally distributed across the population.The HEALIN project will (i) investigate the trends and determinants of HLI, (ii) assess whether the specific ages and causes that drive changes in HLI are the same ones determining the changes in LE, HE and LI indicators, and (iii) investigate how these indicators behave across and within countries and socio-economic groups. In addition, the project aims at making innovative contributions to the measurement of co-morbidity and to our understanding on how the latter can in turn influence the measurement of health expectancy and healthy lifespan inequality. To attain these objectives, the project will develop path-breaking analytical methods inspired in the models applied for the study of inequality and multidimensional poverty. Besides traditional socio-economic and health data sources, the project will complementary draw from the vastly underutilized health regist
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Designing and Thin Film Engineering of Organic Plastic Ionic Ferroelectrics towards Multi-sensor Electronic Skin' (FERROPLAST), addressing dissemination and exploitation.

assistant: **Impact**

Organic plastic ferroelectrics with inherent pyroelectric and piezoelectric properties have the potential to outperform traditional ceramic ferroelectrics, particularly in terms of sustainability and large area fabrication as flexible coatings. The latter is highly sought as means to continue the current evolution of humanoid robots by offering touch sensitive electronic skins. FERROPLAST focuses on development of plastic ionic crystals (PICs) as the active sensitive component of such skins. PICs are comprised of globular ions tethered by weak intermolecular forces and demonstrate plastic crystal phase at higher temperatures. The PIC ferroelectrics possess intriguing features as high pyro and piezoelectric coefficients, malleability, and multi-axial polarization suitable to realize multi-sensor property in flexible thin films. FERROPLAST proposes: (1) Rational designing of PICs based on chirality, ionic size and intermolecular interaction strength to have high pyro/piezoelectric coefficients; (2) Fabrication of crystalline and phase pure PIC thin films embedded in elastomer by molecular layer deposition (MLD) for application as flexible electronic skin; (3) Study of crystal phase landscape in thin films under variable temperature and pressure using grazing incidence XRD to estimate multi-sensor ability of PICs; (4) Selection of ions by insight in entropy of phase transitions as calculated by first principle DFT studies. At the core of FERROPLAST is knowledge building and exchange between the experienced researcher’s background in supramolecular chemistry to design and synthesize PIC ferroelectrics and the host’s core focus on MLD thin film engineering and characterization of physical properties in thin film structures, and the secondment on first principle DFT calculati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A touch of Blue in the EU Research Nights for a more Sustainable Use of the Ocean' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The main objective of the proposal is to bring the many facets and faces of people working in ocean science & research to the general public of Europe by organising a series of interconnected EU Blue Researchers Nights (BlueNIGHTs) to demonstrate that the ocean can be a source of inspiration, an object of interest/study, and a field of investigation for people with very different backgrounds, hobbies and passions, including science, history, technology, sociology, pedagogy, economics, art, design, etc. By doing so, this collective project will: - Bring people to key objectives, principles and priorities of the European Green Deal that relate to the ocean: delivering a healthy and resilient ocean that can support sustainable Blue Growth and respond to Societal Priorities of Europe. - Contribute to make European citizens Ocean Literate in line with the objectives and priorities of EU4Ocean Coalition, an initiative supported by the European Commission's Directorate-General for Maritime Affairs and Fisheries (DG MARE). The project will build on the following principles: - Collective and truly European - mobilising organisations from each EU RSAs to prepare activities and events for presenting their own research/scientific activities. - Interdisciplinary/multidisciplinary/transdisciplinary - the partner organisations from different EU MS will represent a diversity of disciplinary fields and research skills/experiences that are focusing on the ocean, and on the complex connections between human activities and ocean ecosystems. - Immersive, inclusive and interconnected - by combining: (a) an interactive and practical experiences on the spot (in each of the partners location) building on doing, touching, gaming, trying, exploring; (b) an interactive virtual experience, by way o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Characterisation of the Plasmodium PHIST protein family' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The malaria parasite is the ultimate home renovator, inducing drastic changes to the host red blood cell (RBC) important for virulence and sexual maturation. Members of the PHIST protein family are involved RBC modification and while some are expressed in the sexual stages, their function is unknown. To understand the significance of the extensive RBC alterations, the functional characterisation of the PHIST family is required. To begin this task, we have carefully selected 10 PHIST proteins to be analysed. First, we will set up novel techniques based on a microfluidics device that will greatly enhance our ability to study the rheological properties of the infected RBC. These new methods will improve our analysis of the infected RBC and also give unprecedented insights into the RBC modifications during the sexual stages, that to date have not been possible. We will also use cutting-edge molecular and biochemical analyses to ensure we get the highest level of data from such a broad and ambitious project. This embodies the first study to thoroughly investigate the role of RBC modifications in parasite virulence, and transmission of the sexual stages to mosquitoes. Dissecting the underlying mechanisms required to alter RBC will not only help to better understand how the disease develops but also how it’s transmitted, information vital to preventing this debilitating disease. This project will lay the foundation to characterise the entire PHIST family, and while this remains the long-term goal, having 75 family members puts this beyond the scope of this fellowship. In order to be able to characterise such a large protein family, a project such as this is required to carefully and precisely establish a pipeline for generating genetic mutants followed by accurate phenotypic a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Removal of pharmaceutical micro-pollutants from waste water by anaerobic digestion and its effect on nitrogen recovery from digestate by micro-algae.'.

assistant: **Objectives**

Since the advent of the water framework directive (WFD), integrated pollution abatement and river water quality improvement has become a major focus in the management of water resources. At the same time, improving analytical capabilities and ecotoxicological understanding highlighted, somewhat counter-intuitively, new threats to water quality. Micropollutants in the form of pharmaceutical residues (PR) are one such emerging threat, and have been included in the most recent list of related WFD priority and related watch-list substances.This research project will address this threat by application of a combination of existing and novel techniques: 1) investigate the efficacy of anaerobic digestion (AD) for the removal of these PRs not only in conventional treatment of sludges, but also on 2) the novel application of AD to the direct treatment of point source waste waters waste waters rich in these pollutants (e.g. hospital or industry), including feasibility studies on the transfer of membrane-bioreactor technologies from aerobic to anaerobic treatment. Furthermore, 3) the project will combine PR removal by AD with biological nutrient removal (nitrogen) by micro-algae cultivation, thus addressing one of the drawbacks of AD: the lack of nitrogen removal.A particular inter-disciplinary perspective of this project is the inter-relation between 3 aspects of investigation: pollutant removal by AD, resultant ecotoxicological effects on algae and subsequently the recovery of nutrients by algae. The final aim of the project is to elaborate the scope for river water improvement by these techniques, thus contributing to the European aims of water protection and resource efficiency.  This element in particular will be supported by close collaboration with a German public water comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'PrInted gRAphene ThermocouplE for the IoTs'.

assistant: **Innovation**

Accurate real-time temperature measurement is very important in many applications. In particular,  contact-type temperature sensors for nano or microscope measurement of temperature are expected to strongly rise in the next future due to their use in wearables, smartphones, and other consumer electronics devices. However, the development of sensitive and localised temperature sensor is a strong technical challenge, in particular when coupled with flexible substrates, such as those used for packaging and wearables, and the reduced manufacturing cost required for a sensor to be commercially suitable for many IoT applications. The aim of this project is to develop a printed thermocouple made of carbon-based inks, offering accurate temperature measurements as well as better sustainability and biocompatibility, compared to existing solutions.


**Keywords:** printable electronics, temperature sensors, Internet of Things, carbon inks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transnational access to the research infrastructure of the 'son nmr large scale facility for biomolecular research' (1998-2002).

assistant: **Concept**

The current contract for the SON NMR Large-Scale Facility for Biomolecular NMR (SONNMRLSF) started off in November 2001 and has been running now for two consecutive years. The major event that took place during this reporting period has been the arrival and installation of the new Bruker 900 MHz spectrometer in August 2003. It is the second of these costly, highly advanced spectrometers that has become available within the European Cluster of large scale facilities for biomolecular NMR for access to the European scientific community in the context of the Research Infrastructure programme. The operation of this high-end machine is an important step towards opening up new capabilities for structural biomolecular research. Visiting researchers can nowadays make use of the 900 MHz spectrometer and of 6 other spectrometers with magnetic field strengths ranging between 500 and 750 MHz for high-resolution biomolecular solution NMR, a 500 MHz wide-bore solid state system for membrane-related research, and a 200 MHz 40 cm horizontal bore in vivo NMR system for in-vivo (macroscopic) NMR experiments.One of the 600 MHz spectrometers is equipped with a cryoprobe system for enhanced sensitivity. Further on, unique to the infrastructure are the use of two laser systems, a movable argon laser and a excimer laser that is permanently attached to one of the 500 MHz spectrometers, for which a special light-probe is available. These laser systems can be used for performing combinations of light and NMR experiments inside the NMR probe. These NMR spectrometers and the associated probes and auxiliary equipment are capable of the complete range of all currently described advanced high-resolution NMR experiments for structural biology and macroscopic (in-vivo) NMR experiments. In addition to ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Space applications for agriculture and agri-environment'.

assistant: **Innovation**

The SAAGE proposal builds on previous contractor studies that have established the concept of a serviceable remote sensing optical space mission, based on the use of superspectral sensor with proper spatial resolution, potentially complemented by a thermal infrared sensor with a lower resolution and to be used mainly by farming, agri business and agri-environment applications. The major objectives of the SAAGE project are: - to consolidate the mission concept definition through: (i) an analysis of theusers requirements within the EU, (ii) a definition of the Space and Groundsegments with an emphasis on the implementation of the information productsdissemination means - to assess its economic viability through (i) an evaluation of the servicevalue represented by the information products for the users, finallyconverted in a business plan, (ii) a financial scheme for the developmentand the operations of the defined System. SAAGE stands for << Space Applications for AGriculture and Environment >> and is primarily targeting three main classes of users: - the EC and the Member States National Administrations responsible of theEuropean agriculture, environment policies. In particular are targeted theneeds resulting from the new Common Agriculture Policy and the integrationin EU of Eastern European countries. - the farmers community in the frame of the emerging precision farmingpractices ù the agri-business community including agrochemical suppliers,traders, food processors, insurance companies and agronomist consultants Synergy with Water resources management applications will also be considered. This will apply to European and National administrations in charge of the water resource management, to the irrigation management companies an to water distribution companies.The SAAG