RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Seismic Functional Imaging of the Brittle Crust' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite the dramatic impact of earthquakes, the physics of their onset and the short-term behavior of fault are still poorly understood. Using existing high quality seismic observations, we propose to develop a novel functional imaging of the brittle crust to clarify not only structural properties but also the dynamics of faults. We will analyze spatio-temporal changes of elastic properties around fault zones to highlight the interplay between changes in the host rocks and fault slip. Imaging the damage structure around faults and its evolution requires new seismological methods. With novel methods to image the highly heterogeneous fault regions, we will provide multi-scale descriptions of fault zones, including their laterally variable thicknesses and depth dependence. In parallel we will image temporal changes of seismic velocities and scattering strength. External natural forcing terms (e.g. tides, seasonal hydrologic loadings) will be modeled to isolate the signals of tectonic origin.  This will also allow us to monitor the evolving seismic susceptibility, i.e. a measure of the proximity to a critical state of failure. Improved earthquake detection techniques using ‘deep machine learning’ methods will facilitate tracking the evolution of rock damage. The imaging and monitoring will provide time-lapse images of elastic moduli, susceptibility and seismicity. The observed short-time changes of the materials will be included in slip initiation models coupling the weakening of both the friction and the damaged host rocks. Laboratory experiments will shed light on the transition of behavior from granular (shallow fault core) to cohesive (distant host rock) materials. Our initial data cover two well-studied fault regions of high earthquake probability (Southern California
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Increasing the quality as well as the economic efficiency of thermoplastic parts by coating the surface of the mould' under Fourth Framework.

assistant: **Concept**

The objective of this project is the developent and optimization of coating.processes to increase the quality of thermoplastic injection molded parts. Another aim is to improve the economic efficiency of the injection process. In most cases, the most important quality characteristic is the surface quality of the molded part. In order to achieve a good reproduction of the mold surface and to avoid defects such as visible weld lines, high contact temperatures between the mold wall and the plastic melt are needed. In common injection processes such temperatures can only be obtained by meuns high mold wall temperatures, which in turn strongly increase the cycle times and thus reduce the econimic efficiency of the process. Previous experiments have shown that the optical characteristics can be clearly improved by short high contact temperatures. Inside the injection mold this shall be achieved by using suitable coatings as insulation layers. For this, the heat penetration ability of the laminate has to be extremely low. In addition, other properties of the mold surface, such as low wear, topography of the mold surface, heat resistance, elasticity, low tendendy to stick to the plastic, etc. have to be guaranteed. After analyzing the actual status, laminates with the above described characteristics are developed in cooperation with the coating companies. Experimental molds are coated with the different processes and corresponding laminates and are then tested in the K.l.M.W. test center.The first tests include the optical characteristics, the demolding behavior with different types of plastics as well as the economic efficiency. In paralles, the physical laminate characteristics needed for the calculation of the contact emperature, are determined. Afterwards, long-term investi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of electron tomography to study supramolecular assemblies and processes in three dimensions' (1994-1998).

assistant: **Innovation**

Electron tomography (ET) is a method for three-dimensional (3D) reconstruction of objects from a series of projection images (tilt series) recorded with a transmission electron microscope. The method is useful for imaging large macromolecules and supramolecular objects that cannot be obtained in regular arrays. Furthermore, the individual objects can be studied in si tu in relation to other components of the cell. Presently, ET covers the intermediate resolution range of 2.5-5.0 nm. The ET method complements established methods appropriate to reveal the atomic structures of isolated molecular constituents, such as X-ray crystallography. It is expected that ET will prove useful in the molecular analysis of complex structures such as spliceosomes and nuclear pore complexes. In Martinsried, procedures were developed to record tilt series automatically of vitrified specimens at an electron dose where structural details are preserved at atomic-resolution. In Stockholm, a method was developed (constrained maximum entropy tomography, COMET), that permits refinement of 3D reconstructions with low noise level. -- To develop the ET methodology and instrumentation towards a resolution better than 2.5 nm and to be able to handle large supramolecular objects, the following issues will be addressed. 1) The industrial partners Philips and TVIPS will provide advanced instrumentation optimized for ET which is not commercially available: electron microscopes equipped with field emission gun, in-column energy filter and CCD camera will be installed in Martinsried and in Stockholm. 2) The Martinsried group will develop the automated data collection procedures to increase the speed of data collection by a factor of five, and to improve the user-friendliness and applicability. 3) The Stockho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Harmonisation and monitoring platform for certification schemes and labels to advance the sustainability of bio-based systems', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The HARMONITOR project will improve the effectiveness of certification schemes and labels (CSLs) in different sectors of the EU Bioeconomy and therewith strengthen their use as a co-regulation instrument. Effective and robust CSLs can cope with some of the difficulties that public regulation faces and fill in policy gaps. The HARMONITOR project will also establish and test a participative review platform concept that allows CSLs to find commonalities and cooperation when operating in bio-based value chains within and across EU borders. This platform is based on the innovative ‘Sustainability Certification Tools’ proposed by the Horizon 2020 project STAR-ProBio to promote continuous improvement of CSLs and continuous knowledge of these dynamic developments by market actors. The specific objectives of the HARMONITOR project are:1. To establish a review platform to capture the dynamic development of CSLs and encourage their harmonisation and continuous improvement through the exchange of information and promotion of best practices.2. To provide quantitative, transparent data on bio-based value chains through analysis and dissemination of trade flows (certified and non-certified), and quantification of direct and indirect costs and benefits of certification.3. To review and compare performance requirements and assurance and governance systems of CSLs.4. To develop and apply a monitoring system on the effectiveness and robustness of  CSLs.5. To improve the understanding of the opportunities and limitations of using CSLs in co-regulation.The HARMONITOR approach aims to achieve the following outcomes: • Enhanced transparency and traceability of environmental impacts along value chains through improved CSLs. • Higher levels of effectiveness and robustness of CSLs through system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Geographical Variation in Effects of Global Climate Change on the Population Dynamics of Terrestrial Isopods'.

assistant: **Objectives**

Significant uncertainty in predicting future climate change is caused by incompleteunderstanding of the terrestrial components of the global carbon cycle, particularly potential feed backsbetween climate change and CC>2 emissions resulting from changes to biological processes in the soil.Soil animals act as key system regulators of the microbial metabolism that generates CO2. Because soilanimals differ fundamentally from micro-organisms in their life cycles, physiology and mobility theywill respond very differently to changes in climate. The objectives of this project are to investigatehow the population processes of growth and survivorship of a model group of soil macro-decomposers,the terrestrial isopods, will respond to predicted changes in climate acr oss a trans-European gradient ofcontinentality from oceanic in SW Ireland to fully continental in Hungary. Intra-specific variation inresponses to changes in climate will be determined using ecotypes from along the climatic continuumthat have adapted diffe rently to different local climates. Predictions for changes in climate along thegradient of continentality will be made from current models of global climate change. Effects ofchanges in intensity and periodicity of rainfall and in magnitude of daily tempe rature fluctuationsevents on different ecotypes will be determined by a combination of laboratory and field experimentsthe results of which will be used to modify and develop existing population dynamics models. Effectsof biodiversity will be determined by using species with d ifferent m orphological, p hysiological andbehavioural responses to moisture stressThe proposed project will build on the existing skills and knowledge base of the applicant bytraining her in the design of experiments to test a priori hypothe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Low cost manufacturing process for European sme injection-blow moulders' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Industrial Needs and Issues The advent of the injecVon blow moulding process brought with it, the potential for much improved aesthetics within transparent, hollow polymer products, with many being re engineered to take advantage of the significant cost reduction possibilities the process offers. The further development of the process, has allowed our Company, AlppitukRu Oy, along with many of our colleagues amongst the 22,000 SME' plastic moulders and mould tool makers in Europe, to extend our range of hollow products, previously fabricated from a number of injection moulded components and now made as a single piece without a welded knit line. However, many more opportunities would exist if we could cost effectively decorate our mouldings. Despite the development and integration of in line printing equipment, there remains a real commercial need for a cheap, c automated and flexible decoration system, integrated directly into the injection blow mould process itself. This is particularly relevant where components are to be used, simultaneously, in both a functional and aesthetic context, such as the street lighting globes we produce. Where the product is used outdoors and weathering becomes an issue, the current, expensive methods of decorating, such as silk screen printing, foil blocking, shrink sleeve, and spray frosting, also limit product life, as they have to be placed on the external surface which is most prone to UV and rain water attack. Unfortunately, the relative simplicity of current production processes combined with the high labour input required to perform finishing and sub assembly operations, makes it attractive to lower skill and labour cost regions and despite the cost penalties associated with shipping large volume parts, European based manufacturers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unravelling the effect of origin number on the success of genome replication' to be submitted under Horizon 2020.

assistant: **Abstract**

DNA replication must be regulated in eukaryotic cells to ensure that the genome is precisely duplicated. The process is split into two non-overlapping stages: origin “licensing” and origin “firing”. During licensing in G1, ORC loads MCM2-7 onto DNA, and during the firing stage in S phase MCM2-7 is activated to drive replication forks. To prevent re-replication of DNA no new origins must be licensed once S phase begins. Since replication forks can irreversibly stall, it is crucial that sufficient origins are licensed before S phase entry. The “licensing checkpoint” prevents cells in G1 with too few licensed origins from entering S phase. A number of different MCM and ORC mutations have been identified, leading to cancer susceptibility, proliferation defects and/or developmental abnormalities. However, it is hard to explain the spectrum of defects caused by specific mutations, such as in Meier-Gorlin Syndrome. In this project, I will use genome editing to engineer iPS cells with specific mutations in MCM and ORC proteins to determine the effects on origin licensing, licensing checkpoint activation and genome stability. I will use state-of-the-art quantitative proteomics, next generation sequencing and flow cytometry to unravel the molecular mechanisms underpinning the licensing checkpoint and to define the core molecular pathways that coordinate DNA replication and the cell cycle. A comparison of the effect of ORC and MCM mutations in clinically-relevant cells derived from iPSCs and in cancer cell lines will allow me to understand cell-type specific differences in regulation of DNA replication and explain the effects of these mutations on human patients. These new results will open new possibilities to develop specific anti-cancer drugs against selected components of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Experience, Judgement, and Representation of World War II in an Age of Globalization' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

“JudgingHistories” sets out to examine the epistemic premises innate to universalizing historical experience, by scrutinizing the quest for historical understanding and moral judgment against the backdrop of an emerging global cultural environment, fraught with multiple recollections, while using memories of World War II as the empirical core of the study. The pivotal constellation of research emerges by interfacing a horizontal (West-East) alignment traditionally significant for continental European history with a vertically oriented alignment (North-South) that sheds a colonial and post-colonial perspective on World War II. This constellation tends to lead a posteriori to a realm of conflicting, morally permeated discourses of comparison and analogy, revealing the Holocaust to function as the central event of continental narration, on the one hand, while genocidal atrocities highlight the colonial or post-colonial comprehension, perception and narration, on the other. Methodologically, and in order to offer a fresh and innovative view of the emergence of the specifics of knowledge and meaning in the domain of historical understanding in a globalizing world, while placing the signifying event of the Nazis’ systematic annihilation of the Jews at the heart of the question of universal historical judgment, the project proceeds from the colonial periphery of events, however. This “peripheral”, colonial perspective will in a further seemingly paradoxical turn find itself extended into continental European affairs where it functions to help us comprehend the multiplicity of experiences and the diversity of attendant memories unfolding there. Such a research perspective may epistemologically enable us to reconstruct a universally convincing and valid understanding of a founda
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Bridging East and West: Wisdom Literature in Mesopotamian and Greek Traditions'.

assistant: **Objectives**

The project Bridging East and West: Wisdom Literature in Cuneiform and Greek Traditions (BRISDOM) explores similarities and differences in wisdom and its usages in Mesopotamian and Greek traditions. BRISDOM represents the first ever attempt to provide a comprehensive study of wisdom in Mesopotamia and Greece.Wisdom reflects on some of the most fundamental questions of mankind, such as the meaning of life, mortality, and relations with the divine. Wisdom literature had an enormous circulation in both Mesopotamia and Greece and includes very different text types such as sayings, proverbs, fables, books of instructions, diatribes and dialogues. The project has three main objectives: (A) the definition of the corpus of wisdom literature in Mesopotamian and Greek traditions; (B) the definition of the conceptualization of wisdom in Mesopotamian and Greek traditions; (C) the comprehension of similarities and differences of wisdom literary motifs in Mesopotamian and Greek traditions.In order to achieve these objectives BRISDOM will developed a different methodology from previous studies on literary and cultural relations between the East and the West. Rather than focusing on historical connections, BRISDOM will compare the socio-cultural context of wisdom in Mesopotamia and Greece.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Glycosaminoglycan biosynthesis: deciphering the divergent step' (GlycoDIVE).

assistant: **Concept**

Glycosaminoglycans (GAGs) are negatively charged polysaccharides that form a key part of the extracellular matrix in animal tissues, from marine corals to humans. They play crucial roles in cell signaling, mediating processes such as embryonic development, cell growth and proliferation, cell adhesion, anticoagulation, and wound repair. Given their diverse functions, GAG dysregulation is linked to various medical conditions, including neurological, cardiovascular, infectious, and inflammatory diseases, as well as diabetic complications and cancer. While much is known about their roles in health and disease, gaps remain in understanding of how they are synthetized in human tissues. This project aims to investigate glycosyltransferases that participate in the synthesis of heparan sulfate and chondroitin/dermatan sulfate at a molecular level. By integrating biochemistry, structural biology (including cryo-electron microscopy and X-ray crystallography), and cell biology, our goal is to uncover the molecular mechanisms that distinguish these polysaccharides. Thus, this project aims to address fundamental questions in GAG biosynthesis and to provide a molecular basis for the development of GAG-based therapies in future studies.


**Keywords:** Glycosaminoglycan, proteoglycans, glycosyltransferases, heparan sulfate, chondroitin sulfate, dermatan sulfate.