RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Dynamic Interactive Perception-action LEarning in Cognitive Systems' under Seventh Framework.

assistant: **Concept**

The DIPLECS project aims at designing an Artificial Cognitive System architecture that allows for learning and adapting hierarchical perception-action cycles in dynamic and interactive real-world scenarios. The architectural progress will be evaluated within the scenario of a driver assistance system that continuously improves its capabilities by observing the human driver, the car data, and the environment.<br/>The system is expected to emulate and predict the behaviour of the driver, to extract and analyse relevant information from the environment, and to predict the future state of the car in relation to its context in the world. Starting from a rudimentary, pre-specified, i.e., man-modelled system, the architecture is expected to successively replace manually modelled knowledge with learned models, thus improving robustness and flexibility. Bootstrapping and learning is applied at all levels, in a dynamic and interactive context.<br/>Dynamic and interactive context means that the system needs to react at any time to any relevant event and that the action comprises communication to the human driver or direct car control. The architecture applies a hierarchical design principle, where adjacent levels are connected by feedback-loops that require time for processing. Therefore, the potential reaction becomes more advanced through time, i.e., the system provides nested strategies. A real-time operation requires feed-forward mappings, which use the information learned in feedback operation.<br/>The developed methods will be evaluated in three different settings: off-line with data recorded in a real vehicle, online in the real vehicle, and online for a model car. The first setting allows for evaluating methods that take into account the dynamics of the environment, but wh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Combinatorial Aspects of Computational Geometry' to be submitted under Horizon 2020.

assistant: **Abstract**

The project focuses on the interface between computational and combinatorial geometry. Geometric problems emerge in a variety of computational fields that interact with the physical world.The performance of geometric algorithms is determined by the description complexity of theirunderlying combinatorial structures. Hence, most theoretical challenges faced by computational geometryare of a distinctly combinatorial nature.In the past two decades, computational geometry has been revolutionized by the powerful combination of random sampling techniques with the abstract machinery of geometric arrangements. These insights were used, in turn, to establish state-of-the-art results in combinatorial geometry. Nevertheless, a number of fundamental problems remained open and resisted numerous attempts to solve them. Motivated by the recent breakthrough results, in which the PI played a central role, we propose two exciting lines of study with the potential to change the landscape of this field.The first research direction concerns the complexity of Voronoi diagrams -- arguably the most common structures in computational geometry. The second direction concerns combinatorial and algorithmic aspects of geometric intersection structures, including some fundamental open problems in geometric transversal theory. Many of these questions are motivated by geometric variants of general covering and packing problems, and all efficient approximation schemes for them must rely on the intrinsic properties of geometric graphs and hypergraphs.Any progress in responding to these challenges will constitute a major breakthrough in both computational and combinatorial geometry.


**Keywords:** Computational Geometry, Combinatorial Geometry, combinatorial complexity, Voronoi diagram, Delaunay triangula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development and Investigation of Manganese-doped NiFe nanosheet Catalyst for Oxygen Evolution Reaction' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Water splitting is considered as one of the most attractive methods to store renewable energies, especially solar energy. Oxygen evolution reaction (OER) is a main bottleneck of the water splitting. Although hydroxides incorporating both Ni and Fe have been intensively studied due to their promising activity for OER, the reaction mechanism and active catalysts are still under vigorous debate. We propose to introduce manganese (Mn) into monolayer of NiFe layered double hydroxide (LDH). We expect that Mn-induced synergistic electronic effect with Ni and Fe will lead to enhancement of OER activity. Moreover, we will probe the active sites of these catalysts using operando spectroscopic and microscopic techniques. The project will provide guidance for the design of a novel class of multi-component OER catalysts, as well as revolutionary analytical tools for operando characterization of electrocatalysts. The project includes a comprehensive training program to enhance the career perspectives of the fellow.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MIGRants’ strAtegies in carinG for and receiving care from their Elderly parents: Designing paths at the intersection of border, care and labour regimes' to be submitted under Horizon Europe.

assistant: **Abstract**

Analysts and institutions estimate that contemporary societies, especially in the Global North, face an entangled triple challenge: the ageing of the population, ensuring the sustainability of welfare state provisions, and migration. Meanwhile, anti-migration discourses have raised, resulting in migrants’ increasing external and internal bordering. In this context, older migrants, and especially economic migrants’ and refugees’ parents and grandparents, are suspected of excessively drawing on social welfare. Consequently, their entrance to and permanence in Global North countries and their access to care benefits and programs are being limited, leading to new forms of stratification in social reproduction. MIGR-AGE aims to understand how the intersection of care, border and labour regimes shapes the strategies of adult migrants to care for and receive care from their elderly parents. The project focuses on the experience of Colombian families in Italy and Canada, in which elderly parents are (or were until recently) living in Colombia. It combines policy analysis with in-depth interviews, participatory videos, and participatory restitution meetings that will be conducted in the country of emigration in the Global South, Colombia, and in the two countries of immigration in the Global North, Italy and Canada. The project adopts an innovative theoretical and methodological approach that crosses disciplines (sociology, anthropology, political economy, and political sciences) and levels of analysis (at the micro, meso, and macro levels). Moreover, it follows a multi-sited and decolonial perspective that does not only focus on Global North countries but crosses analysis in the Global North/South and emigration/immigration countries to better understand migration patterns and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'EU Intersex Citizenship' (EUICIT) under Horizon 2020.

assistant: **Objectives**

The EUICIT action addresses the rights claims and agendas of intersex people and those with Disorders of Sexual Development (DSD), in response to recent Council of Europe recommendations to revise medical and policy approaches. The term 'Intersex' refers to people born with sex characteristics (chromosomal, gonadal and/or anatomical) not easily classifiable as either male or female; at least 1 person in 2000 is intersex/has DSD. Intersex/DSD people are a highly marginalised section of the EU population. Conflicts exist between those who seek to depathologise intersex and those who seek rights within the medical framework (DSD-oriented. There is a pressing need for research that highlights the experiences, understandings, and views of intersex/DSD people within a European context. In particular, an investigation of debates about intersex versus DSD perspectives is necessary, because of the divergent human rights and social policy implications of these two approaches. EUICIT is framed within interdisciplinary citizenship and participative democratic approaches, in order to highlight human rights issues, and to explore tensions between medical-oriented rights claims and those that seek depathologisation. It uses triangulated qualitative research methods: documentary and policy analysis across the EU, interviews with activists and healthcare/policy actors in Italy, the UK and Switzerland, and participant observation in a secondment organisation (Zwischengeschlecht- ZW). The case study countries were chosen to represent varied types of intersex/DSD activism and relationship to the EU. ZW, which is based in Switzerland, takes a combined medical/activist approach; it is actively engaged in policy work at national and international levels and is ideally suited to fieldwork on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of small molecule inhibitors of circulating tumor cell clusters' under Horizon 2020.

assistant: **Concept**

Despite the great progress that has been made in treating cancer, metastasis remains incurable. Metastasis accounts for 8 million deaths per year worldwide and no agents are currently available to prevent the metastatic spread of cancer. The metastatic process begins with cancer cells leaving the primary tumor site and entering the blood circulation. In circulation, cancer cells are defined as circulating tumor cells (CTCs), and are typically found in the form of single CTCs or small CTC aggregates (CTC clusters). Upon dissemination and survival into distant organs, cancer cells give rise to proliferating metastatic lesions, which in turn can shed other CTCs and form additional metastases. While virtually all oncology-related drugs aim to kill cancer cells within a tumor, no drugs are available to target metastatic cells in circulation. As a consequence, no drugs are available to block or prevent the metastatic cascade.We recently discovered that CTC clusters are exceptionally efficient metastatic precursors, capable to initiate a metastasis 50-times better than single CTCs. Within our ERC Starting Grant Project Holding-Hands, through a screen with 2’456 FDA-approved compounds, we discovered those that enable the disaggregation of CTC clusters in breast cancer mouse models and consequently, lead to metastasis suppression. This exciting new discovery implies that targeting CTC clusters is now feasible, and that this approach is likely to delay or prevent metastasis formation in cancer patients. Thus, within this Proof of Concept application, we aim to screen and patent additional cluster-targeting compounds with higher efficacy and better safety profile, to establish a new company whose aim is to commercialize cluster-targeting molecules, and to prepare for clinical tria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Thermodynamic basis of the inhibition of protein-protein interactions: design principles for the next generation of medicines'.

assistant: **Objectives**

Many biological processes are orchestrated by complex networks of protein-protein interactions and several diseases can be linked to deregulations of these convoluted networks. In spite of their central importance in diseases, very few existing drugs act by disrupting abnormal protein-protein interactions. The discovery of small molecule able to disrupt critical protein-protein interactions has long been considered a very difficult task. Yet, recent successes suggest that this endeavor is feasible but clear strategies to tackle such class of targets have not yet emerged. Among the many medically important protein-protein interactions, the binding of the oncogene MDM2 to the tumor suppressor p53 has attracted intense interest due to its central importance in cancer biology and this system has emerged as a testing ground for design strategies to target effectively protein-protein interactions. In this project, computer simulations and biophysical experiments will be conducted to discover, optimize and characterize inhibitors of the p53/MDM2 as well as the highly similar p53/MDM4 interactions. The effectiveness of the computer aided drug design methodologies will be assessed against this class of target and novel design concepts at the forefront of chemical biology will be applied to develop scaffolds able to disrupt these interactions. Key collaborations will allow the designed inhibitors to be synthesized and tested for biological activity. Thermodynamic studies will also be conducted to characterize the binding properties of successful design and critically assess the predictive power of the computational techniques. The overarching goal of this research will be to not only design potent inhibitors, potentially extraordinarily useful as anti cancer agents, but also to d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative Functional Oxide Materials for Green Hydrogen Energy Production' (H-GREEN) under Horizon Europe.

assistant: **Objectives**

The H-GREEN project aims to address the global energy crisis by advancing pioneering technologies and materials in the photo-, pyro-, and electro-catalysis of water splitting.  The project will leverage the unique properties of functional oxide materials to facilitate the cost-effective production of green hydrogen through water splitting, aligned with climate objectives in Europe.  The consortium consists of fundamental research organizations and industrial companies with the expertise needed to solve this critical problem. Our research partners include the University of Picardie - UPJV (France) and the Joseph Stephan Institute - JSI (Slovenia), as well as the applied Institute for Ceramic Technologies and Systems at FRAUNHOFER Society (Germany). Two industrial companies, NANOTECH (Ukraine) and STERIMED (Morocco), are also part of our consortium. Through secondments and knowledge-sharing training, we'll equip a new cluster of material scientists with the skills and expertise needed to develop H-GREEN technologies that will power the world sustainably.


**Keywords:** Pyrocatalysis, Electrocatalysis, Water Splitting, Green Energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interferometric Survey of Stellar Parameters' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Fundamental stellar parameters are the primary data required for an in-depth understanding of stars, their interiors, and their environments. With the progress of stellar physics and the prospects of ground facilities or space missions, it is critical to improve the accuracy, and quantity of such data. The development of exoplanet and asteroseismology domains is demanding direct data to eliminate any bias in the parameters. And finally, the differences between methods for determining the Hubble constant is motivating new and precise direct determination of distances on the primary candles of the cosmic scales. Many methods like asteroseismology, photometric transits of exoplanets, radial velocities, or Surface Brightness Colour (SBC) relations are linked to the stellar radius. Usually estimated through models, its determination by coupling an optical interferometric measurement of the angular diameter and, for example, a Gaia parallax, is the best way to avoid any model dependence. Furthermore, characterizing any activity (limb darkening, convection, rotation, spots, or binarity) is also mandatory, both for bias removal and for the required progress on stellar physics. Through an ambitious and homogenous survey of the angular diameters of a thousand stars as faint as magnitude 8 in the visible and as small as 0.2 milliseconds of arc, my project is built to address key questions about the relation between planets and stars and to offer to the broader community a unique and primary source of direct information on a representative and large sample of stars all over the HR diagram. A few hundred of direct measurements of limb darkening will be accessible, and, for about 100 stars, activity characterization with a more detailed surface imaging will be possible. These data wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'OlfSwitch: Neural circuit switches from molecules to behaviour' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This proposal seeks to understand the logic of neural circuit switches in the relatively simple nervous system of Drosophila. Our goals are to examine the developmental, physiological and behavioural logic of several of these elementary circuit motifs. We will use innate olfactory behaviour as our primary model, investigating behaviours triggered by single or convergent odour stimuli and their modulation by memory and internal state. We will start with the favourable case of a sexually dimorphic circuit switch that we have recently characterised (for the first time in any animal). We have shown that a transcription factor, fruitless, determines the state of this switch in sex pheromone processing during development. We will now (1) identify the molecules that determine the layout of this specific circuit during development and (2) probe the behavioural relevance of this specific circuit switch.In parallel with this work on pheromone processing, we will examine (3) the circuit basis of valence (simply put whether an odour is attractive or aversive) in which genetic instructions likely hardwire olfactory pathways to downstream modules of different behavioural significance. Finally we will examine the logic of dynamic switches in which a second stimulus (4) positively or (5) negatively gates the response to a stimulus.


**Keywords:** neural circuits, behaviour, olfaction, thermo, optogenetics, single cell RNAseq, in vivo physiology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photoinduced Enantioselective C-H Bond Arylation of Carbonyls via Aryl Thianthrenium Salts' in the context of a Horizon Europe call.

assistant: **Objectives**

The enantioselective arylation of carbonyl compounds is a powerful yet demanding transformation with broad applications in pharmaceutical and agrochemical discovery. Current methods typically require prefunctionalised aryl reagents and costly chiral metal complexes, limiting both scope and sustainability. This project proposes a multicatalytic platform that combines visible-light-driven Cu-catalysed decarboxylation of aryl carboxylic acids to generate aryl thianthrenium salts in situ with chiral amine catalysis via electron donor–acceptor (EDA) complex activation. This strategy employs abundant carboxylic acids as renewable aryl sources, releases only CO2 as a by-product, and delivers high enantioselectivity under mild conditions. Mechanistic investigations will probe radical intermediates and the role of EDA complexes in asymmetric bond formation, providing fundamental insights into multicatalytic photochemical systems. The methodology will enable direct α- and γ-functionalisation of carbonyl compounds, streamline access to enantioenriched scaffolds, and expand the synthetic utility of carboxylic acids as sustainable building blocks.


**Keywords:** α-Arylation, Carbonyl Compounds, Aryl Thianthrenium Salts, Visible-Light Photocatalysis, Electron Donor–Acceptor (EDA) Complex, Decarboxylative Functionalization, Radical Intermediates