RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hydrogen Supply and Transportation using liquid Organic Hydrogen Carriers' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Hydrogen is a versatile energy carrier that will allow the EU to accomplish its strategic targets of zero-emission mobility, integration of renewables and the decarbonisation of industry. However, its low density and explosive nature make hydrogen storage and transport technically challenging, inefficient and very expensive. The Liquid Organic Hydrogen Carrier (LOHC) technology enables safe and efficient high-density hydrogen storage in an easy-to-handle oil, thus eliminating the need for pressurized tanks for storage and transport. The HySTOC project will demonstrate LOHC-based distribution of high purity hydrogen (ISO 14687:2-2012) to a commercially operated hydrogen refueling station (HRS) in Voikoski, Finland, in an unprecedented field test. Dibenzyltoluene, the LOHC material used within HySTOC is not classified as a dangerous good, is hardly flammable and offers a five-fold increase in storage capacity compared with standard high pressure technology, leading to a transport cost reduction of up to 80%. HySTOC comprises 5 partners (including 2 SMEs, 1 industrial and 2 scientific partners) from 3 European countries (Finland, Germany, The Netherlands). The partners cover the whole value chain from basic research and testing (FAU & VTT) through core technology development (Hydrogenious Technologies and HyGear) to the end-user that will operate the LOHC-based hydrogen infrastructure (Woikoski). The comprehensive and complementary mixture of expertise and know-how provided by the consortium ensures not only an efficient realization of the technical and (pre )commercial objectives of the project, but also the subsequent dissemination and exploitation of the achieved results to maximize its impact within the consortium and the hydrogen market as a whole. In the long term, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Role of caspase-11 in inflammasome signaling and the innate immune response'.

assistant: **Objectives**

Innate immune cells such as macrophages and dendritic cells produce potent inflammatory cytokines to mount an appropriate immune response against microbial threats. The related cytokines interleukin (IL)-1beta and IL-18 require cleavage by the cysteine protease caspase-1 to generate biologically active IL-1beta and IL-18. Caspase-1 itself is synthesized as zymogen that interacts with certain members of the intracellular NOD-like receptor (NLR) family in infected macrophages to form large protein complexes named ‘inflammasomes’. The importance of inflammasomes is evident from the genetic variations in the NLR proteins Nalp1 and Nalp3 that are associated with autoinflammatory disorders and increased susceptibility to microbial infection. However, the molecular mechanisms of inflammasome activation and the role of caspase-11 have remained unclear. Caspase-11 has been suggested as an upstream and downstream regulator of caspase-1 functions in LPS-stimulated cells. However, its role in specific infammasomes and its contribution to substrate cleavage in innate immunity remain to be explored. We generated caspase-11 knockout mice to characterize the physiological role of caspase-11 in inflammasome signaling and the innate immune response. In Aim 1, we will characterize the role of caspase-11 in activation of the different caspase-1 inflammasomes. In Aim 2, the proteome-wide caspase-11 degradome will be determined using mass spectrometry-based COFRADIC technology. Primary macrophages from caspase-11 knockout mice will be used to validate the caspase-11 degradome under activating conditions. These approaches will generate a wealth of new information regarding the role of caspase-11 in innate immunity. Elucidating the role of caspase-11 in inflammasome signaling and the innate im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Prognostic Personalized Biomarker and  Therapeutic Target in Blood Cancer Related Fibrosis' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The objective of this ERC Proof of Concept is to demonstrate the clinical application and commercial viability of a specific driver of the innate immune system as a novel predictive biomarker and as a novel therapeutic target for the diagnosis and treatment of bone marrow fibrosis related to blood cancer. This proposed project builds upon recent findings of my deFiber ERC Starting Grant (Stg) project, where we identified this danger-associated molecular pattern complex as exactly as such a prognostic and predictive biomarker and importantly showed that targeting with a small molecular, oral, anti-cancer inhibitor reduced fibrosis but also the cancer cell burden, in the sense of a targetable biomarker.


**Keywords:** blood cancer,  biomarker,  personalized therapy,  targeted therapy,  fibrosis,  bone marrow,  hematopoietic stem cells,  inflammation,  drug repurposing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploiting the secretion machinery of pseudomonads for the nanotechnological production of pharmaceuticals' (NANOFOLDEX).

assistant: **Concept**

The use of enzymes as biocatalysts is a rapidly developing field of immense academic and industrial interest. Several biocatalysts as lipases and penicillinacylases proved to be optimally suited for the Nan technological production of therapeutic compounds including enantiopure pharmaceuticals. At present, however, these biocatalysts cannot be produced in sufficient amounts and at a reasonable price because traditional production hosts like Bacillus and Aspergillums do not support their correct folding and secretion. This proposal aims at providing absolution to this problem by construction of a Gram-negative secretion host strain with its perils engineered into a compartment optimised for the assembly and folding of complex biocatalysts. The barrier in the secretion pathway imposed byte bacterial outer membrane will be overcome by relaxing the selectivity and specificity of the secretion machinery using Nan biotechnological strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ultrafast energy transfer in x-ray-irradiated biological matter' (ULTRAET).

assistant: **Innovation**

Irradiation of matter leads to ionization or excitation of atoms and molecules, with subsequent relaxation processes determining how and where energy is deposited. Understanding these mechanisms is essential for technologies that require precise control of energy conversion and deposition. Recently, non-local energy transfer processes—most notably Interatomic Coulombic Decay (ICD)—have gained attention for their central role in radiation-induced damage to biological systems. While ICD is well established as an ultrafast low-energy transfer pathway, recent studies suggest that even larger amounts of energy can be transferred to the environment.This project will explore such high-energy transfer in biological matter and identify the conditions under which it is efficient. The focus is on divalent metal cations (Mg²⁺, Ca²⁺, Zn²⁺) which are vital to biological function, and how they release energy to their aqueous environment after core-level ionization. To study this, state-of-the-art ab initio quantum-mechanical approaches for electronic decay will be extended to include relativistic effects, benchmarked against experimental x-ray and electron spectra, and systematically tested to reveal the strengths and limitations of current theoretical tools. The outcome will be new computational strategies that enable predictions of energy transfer at the molecular scale with unprecedented accuracy.By combining novel method and code development with large-scale high-performance simulations, the project bridges fundamental theory with real-world observations. Collaborations with leading European experimental groups will ensure rapid validation and broad dissemination of results. Beyond advancing our understanding of radiation effects on biological matter at the microscopic level, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tracking and evaluating social relations and potential partners in infancy' (PARTNERS).

assistant: **Concept**

In order to navigate the social world, children must understand how social interactions unfold in their society. While many recent studies have investigated how children evaluate the roles that people play in everyday interactions and what inferences they draw from their observations, to date there is no unifying account for the conceptual repertoire and computational mechanisms used by infants to analyse their social environment. Taking a new theoretical perspective on this topic, we plan to study whether and how human infants and young children are able to infer the social relations that underlie observed interactions. The theoretical background of this approach is based on the combination of two proposals: (1) that actions are analysed in terms of the costs and benefits they produce to the actors and others affected, and (2) Alan Fiske’s theory, according to which human social relations could be classified into basic elementary forms. Using a variety of behavioural and neuroimaging techniques, we intend to investigate whether children infer the specific social relation that the intentional structure and the cost-benefit outcome of an observed interaction could reveal. More specifically, while resource transfer events (e.g., giving, taking) alter the distribution of goods among participants, they may also cue certain types of underlying relations that would ensure that all parties benefit, directly or indirectly, from the exchange on the long run (e.g., by reciprocity). We aim to establish whether drawing inferences to social relations enjoys the priority in the infant mind over attribution of social dispositions, whether infants predict the outcome of new, previously unobserved interactions, what information children use to choose partners for cooperative tasks, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Reputation and Social Media Management Hub to Help Enterprises Manage Dispersed Online Public Information' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

More and more companies are discovering the possibilities that social media sites such as Facebook and YouTube hold for maintaining a conversation with their customers, as well as keeping their brand(s) top-of-mind for the consumer in an extremely cost-effective way. The PR 2.0 proposal addresses the need for European SMEs to take advantage of the benefits of using social media to increase their competitiveness by offering an affordable, cost-effective centralised web tool for management of marketing campaigns using popular social media tools such as social networks and microblogging platforms. In addition, PR 2.0 will allow companies large and small to easily monitor user-generated content about their business or brands, allowing them to easily manage their online reputation, be alerted to possible public relations crises and take immediate actions. A cloud computing model for the exploitation of the project results will ensure that the PR2.0 project is accessible to SMEs and a user-centered user interface will ensure that the system is in line with their skill set and needs. Opinion Mining techniques and advanced web design and development methodologies and a user-centered design perspective will be used in this project with the aim of achieving the objective of developing a novel tool in a fast-paced, ever changing environment like social media and with a potential impact not only in the PR and marketing sector but in almost any business activity. The commercialisation of the PR2.0 tool will result in economic benefits for the consortium, savings and improvement of competitiveness for the PR 2.0 users, and, by the generation of training material and guidelines, the PR2.0 will also educate on and encourage the use of Web 2.0 tools among the European SMEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Research and development of a new plumb line universal monitoring system' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The project aims at the research and development of a new range of instruments, based on the plumb-line principle but with innovative measuring techniques, to monitor rotations that may occur to foundations or structures. They will offer increased precision and reliability coupled with cost curbing down to roughly 1/3. They will be equipped with high friendly interface for easy utilisation even by unskilled users and employment in stand-alone configurations or in automated survey systems. They will replace, almost entirely, the various measuring techniques so far in use which are very expensive and therefore have a limited utilisation. Massive monitoring on world-wide scale of civil engineering works - e.g. dams, bridges, ports, communication lines, etc. - could be achieved at much reduced costs with improved precision and reliability thus resulting in increased safety conditions of population leaving nearby .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Bio-engineered micro Encapsulation of Active agents Delivered to Shellfish' to be submitted under Seventh Framework.

assistant: **Abstract**

The project aims to continue with some exciting work following up a development in delivering active agents to bivalve molluscs through micro-encapsulation. The early work showed that bacteria with a potential in vitro to break down some algal toxins could be effectively delivered to the gut of the bivalve. The size and nature of the micro-capsule (bead) was shown to be key. The SMEs and Other industry partners in the consortium have assempled a group of leading researchers in the field to develop this work , further, and to look into not only active detoxification but more effective depuration using pro-biotics. The group alsp plan to investigate the use of the 'beads' as carriers of active agents to aid an immunostimulant response against attack by the Bonamia parasite on European (flat) Oysters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Feminist movements responses to the gendered impact of crises (Gender, Resilience and Activism in Crisis Europe)'.

assistant: **Innovation**

The gendered effects of the current pandemic crisis – i.e. how the economic, social, and political problems prompted by the COVID-19 health crisis affect women, men, Lesbian, Gay, Bisexual, Transgender, and Intersex people differently – are amongst the most visible and significant ones, yet continue to be largely underestimated in the mainstream political, policy, and academic debates. Women have and will continue to endure the social, economic and political damage generated by the crisis, due to precarious work conditions as well as unpaid care and housework. In this context, feminist movements have been capable to (re)introduce contentious claims over the deep meaning of the crisis and its consequences, raising public concern over imperative issues such as gender-based violence, reproductive rights and the centrality of care and social reproduction work as the material basis to sustain life. Against the backdrop, GRACE investigates how feminist movements address the gendered consequences of the crisis by looking at the variation in mobilization opportunities, strategies and policy outcomes in two national cases: Italy and Spain. It does so by examining feminist movements in: a) online and offline strategic choices, tactical innovation and changes in mobilization style; b) forms of (re)organization in the physical and digital space; c) discourses and knowledge production adopted to influence institutional actors and public opinion. Based on a mix-methods and cross-national comparative research design, GRACE aims to enhance the understanding of gender inequalities across contexts, crises’ consequences, and the influence of feminist movements on public policy. In doing so, GRACE will produce crucial knowledge to academics and policy makers to understand how the current c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Systematic Triangulation of Pathobiont-Host-Interactions' (SOAR) targeting Horizon Europe.

assistant: **Abstract**

Rising incidences of chronic disorders and cancer have been linked to reduced microbial diversity. Genetic risk factors are similarly involved in the development of chronic disorders and cancer. The effect of both microbial and genetic factors is particularly evident in inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, the identification of specific bacteria that trigger/drive disease or modulate therapy efficacy in IBD and CRC lacks a comprehensive approach. Even less is known about how these bacteria mechanistically induce such effects. The paucity of so far identified disease relevant bacteria and their mode of action, likely lies in the complexity of both the microbiome and the host’s genetic risk factors. We hypothesize that specific bacteria, which do not harm the host under steady state conditions, hijack host pathways in the presence of certain genetic risk factors to drive inflammation, onset and progression of IBD and CRC. We speculate that these bacteria, termed pathobionts, have so far been overlooked due to a lack of methods to triangulate these disease relevant bacteria in multi-factorial disorders like IBD and CRC. It is our objective to identify these pathobionts and match them to host genetic risk. To do so, we have developed an antibody coating based approach, to identify and culture pathobionts. Now, we want to overhaul our approach to develop a high throughput-pathobiont identification technology. Through machine learning, we then aim to find pathobiont-host genetic risk matches that drive disease and validate these matches in vivo. Lastly, we plan to demonstrate the potential of our new technology and gained knowledge. Through leveraging the gained knowledge, we aim to identify pathobiont-host risk matches in publicly available