RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ANTAGONISTS OF PROTEIN-PROTEIN INTERACTIONS' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Dysregulation of cytokine gene expression and cytokine regulated gene expression is the root cause of many diseases including viral and bacterial infections and chronic inflammation. In recent years, a variety of molecular biology and biochemistry research tools enabled the study of direct protein-protein interactions among various cytokine receptors and transcription factors which establish, maintain, and coordinate transcriptional regulation of cytokine genes. Currently, novel technologies and emerging statistical tools have enabled the use of translational genomics which involves the study of large sets of genes and proteins, with the goal of understanding systems, not simply components. An excellent complement to state of the art will be to apply translational genomic tools and molecular biology techniques to establish novel experimental models leading to a functional understanding of disease and the development of systems-based medical solutions. The aim of this proposal is to enable the researcher to acquire substantiated state of knowledge in translational genetics in the partner organisation ""Translational Genomics Research Institute"" (TGen) which provides the data and tools necessary to identify the genes that play a role in hereditable diseases and understand the genetic changes contributing to disease progression. The researcher will assemble its own genomic research platform in order to translate genetic information of infection and inflammation diseases at TGen. She will build up a new independent platform in The Helmholtz Centre for Infection Research (HZI) which utilizes translational genetics research to establish infection and inflammation relevant cell-based models and uses chemical biology and competent compound collections in HZI to identify and cr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High resolution and chemical genetic approaches to RNA silencing mechanisms' (2007-2013).

assistant: **Innovation**

In eukaryotes, silencing small (s)RNAs, including micro (mi)RNAs and small interfering (si)RNAs, regulate many aspects of biology, including cell differentiation, development, hormonal responses, or defense. In particular, many plant and metazoan miRNAs play crucial roles in embryonic/post-embryonic development; the precise timing and localization of their expression is thus crucial to their action. Hence, specific miRNA repertoires underlie specific cell identities, and deviations from such repertoires often have deleterious consequences such as cancer. Many miRNAs also help organisms to adapt to stress, thus, given their importance in virtually all aspects of biology, understanding how, when and where miRNAs exert their actions is of paramount importance. To date, however, the few approaches to miRNA-mediated silencing in whole organisms have not taken into account the exquisite definition, in space and time, of their biogenesis and action, leading to an inaccurate view of the biology of these molecules at the systems level.Using the root system of the model plant Arabidopsis thaliana, we propose to explore, at single-cell and subcellular resolution levels, the biology of the main miRNA effector protein, ARGONAUTE 1 (AGO1) in intact tissues. Using a combination of state-of the-art technologies for single-cell forward genetics, protein purification and RNA/polysome profiling, we will establish a functional spatiotemporal map of the root AGO1-sRNAome and identify cell-specific modifiers of sRNA biogenesis and action. As a complement to the above approaches, chemical genetics will isolate small molecules allowing direct and specific manipulation of AGO1-dependent sRNA pathways in planta. RNA silencing modifier compounds will also accelerate forward and reverse approaches
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Safe Port Operations using EGNOS SoL Services' (SAFEPORT), addressing dissemination and exploitation.

assistant: **Impact**

The main aim of SafePort is to assist the move towards safe and efficient control of the transit of all vessels in a port from the port entrance to their berths and out again. In order to realise this aim we need to develop 2 separate but interdependent systems.1.The first is an Active Vessel Traffic Management and Information System, or A-VTMIS [Stateczny, 2005]. The idea of which is to take the state of the art in VTMIS which is a passive system providing information and advisories and use this as a basis to actively manage the transit of all vessels in the jurisdiction of the VTMIS. The A-VTMIS must plan provably safe paths for multiple vessels as they arrive from the entrance to the harbour to their berths and ensure that the vessels follow these paths safely without conflicting with the paths of other vessels.2.The second system is a pilot aid (SafePilot) which will ensure that crew or harbour pilot can safely and efficiently navigate the courses provided by the A-VTMIS and execute precision docking manoeuvres for large vesselsIn order to achieve these objectives the accuracy, reliability and SoL aspects of EGNOS are critical. The combination of the accuracy, the availability of the integrity function, and the availability of a single standardised service offer at all European Ports mean that we will be able to develop an A-VTMIS which will be capable of  planning and managing efficient and safe paths for multiple vessels. Additionally, the implementation of authentication mechanisms to support identification and safe recognition of assets in the Maritime operations (e.g. Cargo, ships, vehicles, etc.) as complementary to the SiS authentication provided by SoL services is essential for safety-related operations. SafePilot will exploit the EGNOS Commercial Data Distr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Monitoring Eye gaze and pupillometry for Reading and Language Integration in Neurodevelopment' in the context of a Horizon Europe call.

assistant: **Objectives**

Reading difficulties remain one of the most underestimated barriers to education and career opportunities. While dyslexia and other Specific Learning Disorders are usually identified in childhood, many adolescents and young adults continue to struggle, especially with silent reading – the most used modality in academic and professional life. Current assessment methods face major limitations: (i) they focus on performance metrics like words-per-minute or comprehension questions, without capturing the hidden cognitive load; (ii) they center on oral reading, with only artificial and non-ecological tools available for silent reading; and (iii) their sensitivity decreases with age, failing to capture compensatory strategies that mask difficulties at a high cognitive cost. MERLIN (Monitoring Eye gaze and pupillometry for Reading and Language Integration in Neurodevelopment) will develop INnerSIGHT, a non-invasive tool enabling precise, quantitative assessment of fluency and cognitive effort during aloud and silent reading. It combines lightweight head-mounted eyetrackers, a spiral booklet of validated reading passages, and a custom software to integrate gaze behavior and pupillary response with the read text. Building on the promising results of the ERC wHiSPER project on gaze and pupillometry as markers of cognitive effort in ecological tasks, MERLIN will: (i) develop the INnerSIGHT software, textual stimuli, and assessment procedures; (ii) validate its effectiveness in a large cohort of neurotypical adolescents and young adults in schools and laboratories, and in a clinical cohort of dyslexic participants in collaboration with expert clinicians; and (iii) define a feasible market strategy to maximize its impact. The resulting INnerSIGHT system will represent a holistic tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Intelligent Vessels using space technology for Safety on board.'.

assistant: **Objectives**

i-vSave is a disruptive maritime communication system with integrated satellite communication and positioning, GSM /3G connectivity, on-board  LoRa sensor network and a terrestrial server for data processing and management, that promotes overall communications, safety and crew/passenger comfort on merchant, passenger and recreational vessels. Maritime companies, crew and passenger (target users) have a need for real-time information exchange, safety and 24/7 connectivity. I-vSave collects and processes data from satellites, databases and sensors to enhance decision-making by captain, provide fleet management tools and alert in the case of safety threats, while the on-board sensor network monitors the ships’ operation and guard passenger and crew safety (LoRa man overboard). Furthermore, crew and passengers benefit by 24/7 communication services (GSM/Wi-Fi) at global coverage of up to 99%. The innovation lies in the integrated solution solving the needs of maritime companies, crew, passengers and other maritime stakeholder. A hardware prototype has been developed and the system has been tested in the port of Algecira, such that the project is at TRL6. However, satellite data & communications and software and firmware development form a key pillar in this project, for which we require a feasibility study. Upon commercialization of i-vSave in 2020, we will sell our product in Europe, Asia and USA where more than 90% of the shipbuilding, maintenance, repair and conversion (SMRC) market is located. For Phase II a budget of € 1.2M is estimated. As a result of i-vSave, product revenues will reach € 6.2M in the 5th year with a ROI of 3.9. The company will have grown by 6 employees. Europe has the largest global market for passenger and cruise vessels and our solution will speci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The degradation of piezoelectric ceramics for actuator applications' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content The objective of the proposed research is to improve the current understanding of the mechanical origin of effects that influence the electromechanical behaviour of piezoelectric ceramics. In particular the degradation of their piezoelectric and mechanical properties which will ultimately limit their performance and potential applications. Piezoelectric ceramics are already used widely for mechanical actuators, ultrasonic applications, resonators and load sensors. For most applications they do not require high strength, but more importantly they do require long term stability and reliability. The electrical and mechanical cycling of piezoelectrics, however, can cause irreversible microstructural damage in the form of microcracking and reversible damage in the form of ferroelectric domain reorientation. This leads to non-reproducibility and degradation of electromechanical properties and increased electrical and mechanical losses. It is well known, for instance, that the performance of piezoelectric displacement actuators degrade during long-term applications. The problem is becoming more important as components are increasingly being used in applications that subject them to relatively large cyclic electrical and mechanical loading. Training content (objective, benefit and expected impact) Working in the Fracture, Creep and Fatigue group at QMW will provide a very active and stimulating environment in which to develop my research skills. The experience and skills of the researchers within the group will be of considerable assistance to me in achieving the objective,s .of my proposed research. The group has an international reputation and attracts many visitors for short and long stays -it was during a short research visit that I made my i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DNA-guided self-organized active materials' in the context of a Horizon 2020 call.

assistant: **Objectives**

Programming the autonomous and multiscale structuring of shapeless synthetic soft matter is unknown and conceptually challenging. In stark contrast, a living embryo is highly ordered at all levels – from cells to the entire organism. The ordering is a multistep process, starting from the patterning of biomolecules (morphogens) which later instruct autonomous shape transformations (morphogenesis). Inspired by these natural physicochemical processes, we aim at the preparation of a first-ever synthetic biocompatible material which can be self-organized in a programmable and autonomous manner. The programming will be achieved by an out-of-equilibrium DNA-based chemical network which predictably generates single-stranded DNA morphogens. Combined with diffusion, the concentrations of the morphogen can be patterned with a unique spatiotemporal precision, including travelling waves and stable fronts, which were pioneered by the host group. The autonomy of morphological structuring will be accomplished by linking the mechanical activity of active gels, composed of DNA-kinesins and microtubules, to the presence of the DNA morphogen. Latter will act as a cross-linker creating the clusters of kinesins and thus guiding the self-organization of the soft material by the collective action of nanoscale kinesin motor proteins which exert force on microtubules. Apart from the preparation of a first biocompatible man-made morphogenetic material, we will learn how the self-organization of active gels is dependent on morphogens’ patterns. This knowledge is indispensable for the advanced programming of the precise macroscale shapes at the molecular level of chemical networks, which are diverse and modular. With further developments, our methodology could lead to so far elusive self-fabricated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Citizen Information Tool in smart AdministraTIONs' (CITATION).

assistant: **Innovation**

CITATION aims at providing citizens with an intelligent ambient for the provision of governmental services in the administration sector, meeting their needs for customised information delivery and flexible access. CITATION will create an innovative information platform that addresses the needs of both national and non- national citizens for direct access to essential public data (administration, legislation, available services). CITATION system will provide several innovative features, such as convenience and flexibility in access, intelligent information categorisation, user profiling, customisation of information, multi-functionality and multilinguality. CITATION utilises upon the vast pool of information in the healthcare administration and integrates a great variety of services concerning medical and social insurance, specific reimbursement requirements, patient intake procedures, government policies and initiatives on health, family planning etc.OBJECTIVESCITATION will create an innovative platform for all European Union citizens that will improve and promote electronic government services, ensuring that citizens have easy and direct access to essential public data (administrative procedures, legislation and available services). The objective will be accomplished through the development of a technologically innovative platform for the administration, customisation and flexible delivery of administrative information. CITATION will embrace the initiative and effort of all actors to provide and promote health-related administrative information, in the framework of local or national government services.DESCRIPTION OF WORKAccording to the user needs analysis the system architecture and the detailed functional specification of the system will be prepared. The identificat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Subpolar Ocean Programme Phase 2: The Thermohaline Circulation in the Greenland Sea' (ESOP-2).

assistant: **Innovation**

The goal of ESOP-2 is to understand the thermohaline circulation in the Greenland Sea, its sensitivity, and impact on global ocean circulation, building on a unique combination of novel experimental techniques, modelling and experience gained under ESOP-I. ESOP-2 combines 21 partners from 8 European countries. Specific objectives: - To understand the oceanic thermohaline circulation on meso and large scales and its dependence on surface fluxes of heat, fresh water and momentum. - To follow the fate of the newly formed waters as they leave into the Norwegian Sea, the Iceland Sea, and over the Denmark Strait, thus contributing to the global ocean circulation. - To obtain a quantitative estimate of both the depth and the integrated extent of the deep winter-time mixing. - To quantify rates of mixing in summer at shallow (approx. 300 m) levels in the Greenland Sea gyre. - To study the importance of internal mixing processes for the transformation of water masses. - To assess the lateral exchanges between the rim and the central gyre of the Greenland Sea. - To study fresh water fluxes into and out of the central Greenland Sea region. - To study ice growth and decay and consequent salt fluxes and overturning within the central Greenland Sea region. - Evaluate the role of convection areas in ocean-atmosphere gas exchange. - Investigate the role of thermohaline circulation in CO2 transport. - To provide precise calculations of carbon fluxes and carbon budgets in active convection areas like the Greenland Sea, and evaluate the efficiency of the convection areas in the oceanic uptake CO2. - To provide better constraints on the global carbon budgets. - To use observations to improve and calibrate coupled atmosphere-ocean models One of the main issues in marine research today is to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'IMPLEMENTATION OF A FLASH-EEPROM TECHNOLOGY FOR DEMAND DRIVEN EMBEDDED APPLICATIONS'.

assistant: **Concept**

Flash-EEPROMs (electrically erasable programmable read-only memory) are non-volatile memories (NVM) that according to many forecasts, will become one of the main technology drivers in the world of electronics. Flash-EEPROMs are well suited for stand-alone memories, as well as embedded memory applications. The number of European semiconductor manufactures providing NVM is, however, rather small. The worldwide NVM market is dominated by non-European companies. Therefore, innovative small or medium sized companies, with clear demand for (Flash-) EEPROMs, but with rather moderate order volumes, cannot find sufficient support from present NVM technology providers.The objectives of the project were to:- disseminate the know-how accumulated in European research institutes- provide new, cost effective technologies that can lead to innovative design solutions- minimize the dependence of European customers, system houses and design centers on non-European providers of NVM-Technology- strengthen the position of European semiconductor manufacturers in the NVM-market for embedded applications.A consortium was set up in order to transfer and validate a CMOS compatible Non Volatile Memory technology into an industrial manufacturing environment. The consortium consisted of three European partners, located in different countries: one Research Institute and two Industrial Partners. The Research Institute was the inventor and owner of the specific NVM cell, technology know-how and related patents. One of the industrial partners, the Semiconductor Manufacturer, acted as a site of the technology implementation, whereas the second one, a System House, acted as a customer providing a detailed specification of the architecture and the function of the demonstrator circuit.The System House carri