RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Synthesis of small molecules and evaluation of their biological activity: discovery of new protein-protein interaction inhibitors' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

(1)  GoalThe project goal is to exploit diversity-oriented synthesis (DOS) to discover protein-protein interaction (PPI) inhibitors of gankyrin-S6 complex.(2)  TopicVital cellular functions are all regulated by protein complexes. In order for a complex to work correctly, interactions among its subunits must have the right intensity. If they are too weak or too strong, the complex does not work well, causing disease. Thus, modulation of PPIs offers a strategy for therapy. Gankyrin is a protein that forms a complex with the S6 subunit of ATPase in 26S proteasome. This complex is overexpressed in hepatocellular and oesophageal cancers, so its inhibition would offer a strategy for the treatment of such diseases. Unfortunately, the development of PPI modulators is challenging, mainly because the libraries of compounds used for biological screening have a limited structural diversity and a low probability to contain an active compound. A new synthetic strategy is necessary to solve this problem.(3)  SignificanceDOS affords the highest structural diversity in compound libraries, maximising the chances to find an active molecule. PPI inhibitors of gankyrin could become the first drugs against oesophageal and hepatic cancers, for which no pharmacological treatment exist.(4)  MethodsThe project will involve four steps: 1) structure-guided design of gankyrin ligands; 2) their chemical synthesis; 3) test of their inhibitory properties on gankyrin and 4) structural characterization of the protein-inhibitor complex. The process will be iterative: based on biological results, new compounds will be designed and synthesized.(5)  ImpactThe development of drugs against two incurable diseases would have a benefit for millions of people. The fellowship will provide the researcher with new k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a Decision Support System for Improved Resilience & Sustainable Reconstruction of historic areas to cope with Climate Change & Extreme Events based on Novel Sensors and Modelling Tools' under Horizon 2020.

assistant: **Concept**

HYPERION aims to introduce a research framework for downscaling the created climate and atmospheric composition as well as associated risk maps down to the 1x1 km (historic area) scale, and specific damage functions for Cultural Heritage (CH) materials. Applying atmospheric modelling for specific Climate Change (CC) scenarios at such refined spatial and time scales allows for an accurate quantitative and qualitative impact assessment of the estimated micro-climatic and atmospheric stressors. HYPERION will perform combined hygrothermal and structural/geotechnical analysis of the CH sites (indoor climate, HVAC, related strains and stresses, etc.) and damage assessment under normal and changed conditions, based on the climatic zone, the micro-climate conditions, the petrographic and textural features of building materials, historic data for the structures, the effect of previous restoration processes and the environmental/physical characteristics of the surrounding environment. The data coming from the integrated monitoring system will be coupled with simulated data (under our holistic resilience assessment platform-HRAP) and will be further analysed through our data management system, while supporting communities’ participation and public awareness. The data from the monitoring system will feed the DSS so as to provide proper adaptation and mitigation strategies, and support sustainable reconstruction plans for the CH damages. The produced vulnerability map will be used by the local authorities to assess the threats of CC (and other natural hazards), visualize the built heritage and cultural landscape under future climate scenarios, model the effects of different adaptation strategies, and ultimately prioritize any rehabilitation actions to best allocate funds in both pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A fast, cost-effective breath analysis technology for Helicobacter pYlori screening at both large and small scale.'.

assistant: **Objectives**

The increasing incidence of Helicobacter (H.) pylori infections and their close link with gastric cancer, gastric lymphoma, duodenal and gastric ulceration, give impetus to the H. pylori diagnostics market. Existing solutions are too costly, inconvenient and invasive; have a long analysis time or need technical expertise to analyse. Bedfont Scientific Ltd offers a portable H. pylori diagnostic device, HYscreen, which detects ammonia in exhaled air as a biomarker for H. pylori. It has a rapid diagnosis, higher accuracy, lower cost, greater simplicity and convenience. It has the following innovation features: a mouthpiece breath entrapment sampling system, a thermal oxidizer and a Nitrogen Oxide (NO) sensor. This solution is aimed at primary and secondary care in Europe and USA and population screening programs in Asia, answering the call for a cheaper, quicker and simpler monitoring device. This will lead to improved clinical decisions that will facilitate early treatment of the infection, preventing H pylori related cases of gastric cancer and gastric or duodenal ulcers. Consequently, Europe-wide and global savings of up to €1.5 billion and €5.66 billion respectively will be realized by avoiding unnecessary endoscopies, biopsies, expensive H. pylori tests and the healthcare bill from H. pylori-related conditions. Ultimately, HYscreen will open doors for fast and affordable population wide screening. The test will use cheaper C12 urea, though work still needs to be done to make it commercially available.There is a challenge to shorten the thermal oxidizer system for better aesthetics and to reduce ammonia absorption. In Phase 1, we study the feasibility of optimizing the thermal oxidizer system, the use and optimization of C12 urea, protection of the product and the deta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Scalable software hardware architecture platform for embedded systems' (SHAPES), addressing dissemination and exploitation.

assistant: **Impact**

There is no processing power ceiling for low consumption, low cost, dense DSP for future embedded human-centric applications treating audio, video, ultrasound and antenna signals.Nanoscale systems on chip will integrate billion-gate designs. The challenge is to find a scalable HW/SW design style for future CMOS technologies. The main problem is wiring, which threats Moore's law. Tiled architectures suggest a possible HW path: 'small' processing tiles connected by 'short wires'. The SW challenge is to provide a simple and efficient programming environment.SHAPES investigates a groundbreaking HW/SW architecture paradigm.The heterogeneous SHAPES tile is composed of a VLIW floating-point DSP, a RISC, on chip memory, and a network interface. For optimal balance among parallelism, local memory, and IP reuse on future technologies the tile gate count is limited to a few million gates.The SHAPES routing fabric connects on-chip and off-chip tiles, weaving a distributed packet switching network. 3D next-neighbors engineering methodologies will be studied for off-chip networking and maximum system density.For efficient programming, SHAPES will investigate a layered system software which does not destroy algorithmic and distribution info provided by the programmer and which is fully aware of the HW paradigm.For efficiency and QoS, the system SW manages intra-tile and inter-tile latencies, bandwidths, computing resources, using static and dynamic profiling.The SW accesses the on-chip and off-chip networks through a homogeneous interface. The same HW and SW interface is adopted for integration with signal acquisition and reconfigurable logic tiles.Generation after generation, the number of tiles on a single-chip will grow, but the application will be portable.SHAPES will set a new de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Partially Coherent Many-Body Nonequilibrium Dynamics for Information Applications'.

assistant: **Objectives**

I propose to investigate two closely connected themes which aim to exploit the full potential of quantum mechanics in information technology. Both the themes concern the exploitation of the nonequilibrium dynamics of many strongly coupled quantum systems which is recently becoming feasible to observe in a plethora of engineered systems. As one broad objective, I plan to examine automata made from a multiple quantum units such as nanomagnets for transporting bits and performing classical (Boolean) reversible logic. In a similar vein, coding of bits in domains of engineered quantum many-body systems and their exploitation for Boolean computing will be explored, as well as examine the quantum nonequilibrium dynamics of a processor which combines transport and processing together. The open nature of the constituent quantum systems will be an integral part of our calculations which will be set in a regime where dissipation (decay of energy from the system) is not significant, though dephasing (loss  of quantum coherence) may be substantial. I foresee the advantage of such automata in highly energy efficient and fast computation whose speed is set by the couplings of the quantum many-body system. The second broad objective seeks to overcome a formidable obstacle in the physical implementation of quantum computation, namely the high control demanded on every quantum bit and their interactions with other quantum bits. I plan to offer and investigate an alternative paradigm where the information is processed by harnessing the minimally controlled dynamics of quantum many-body systems. In this context, I will look both at general questions such as to whether a network of interacting spins can serve as an automata for running an entire quantum algorithm, whether magnon wavepackets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Patients' Academy on Therapeutic Innovation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposed project ""European Patients' Academy on Therapeutic Innovation"" (EUPATI) contributes to IMI’s goal of raising patients’ awareness and participation in pharmaceutical R&D. This patient-led academy will provide scientifically reliable, objective, comprehensive information to patients on pharmaceutical R&D. It will increase the capacity of well-informed patients to be effective advocates and advisors, e.g. in pharmaceutical development, with regulatory authorities and in ethics committees. The Consortium, led by the European Patients' Forum, comprises a unique combination of pan-European patient organisations, academic and not-for profit organisations and 16 EFPIA member companies. It features excellence across disease areas in state-of-the art, high quality, objective education to patients about therapeutic innovation. Supported by an innovative e-platform, EUPATI's network of patients, experts, companies and communicators develops recognised blended learning courses for patients to become 'Patient Experts' in treatment development. It provides educational materials for patient organisations as well as a Wiki-type platform available to all patients in 6 areas of interest. It drives the newest thinking in content and delivery, and harnesses previously ad-hoc activities in a coherent, strategic, quality-oriented and sustainable way. It informs the lay and hard to reach patient community, raising public awareness of the development of new treatments. EUPATI makes a substantial and measurable difference to patients, laying the base for meaningful involvement and empowerment of patients in pharmaceutical innovation, safety of medicines and access to treatments. EUPATI creates synergies across its public and private partners to galvanize the most effective, transp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Evaluation and modelling of benefits and costs of fish welfare interventions in European Aquaculture' (BENEFISH).

assistant: **Innovation**

BENEFISH will explore the benefits and costs of welfare measures in aquaculture production systems. Our strategy is to define a widely applicable set of operational welfare actions and indicators that can be connected to measurable consequences in production and extended to effects on value chain and changes in consumer perception. BENEFISH will produce a scientific basis for comparing biological effects and monetary influences of various welfare measures by developing a high-level decision analysis model.The main objectives of BENEFISH are:1) using a set of widely applicable operational welfare indicators, define relationships between selected welfare control measures and their consequences for production, quality and consumer perception,2) estimate the costs and benefits of potential welfare control measures and their documentation through case studies,3) develop a decision analysis model allowing comparison between various welfare control measures on the basis of their biological and monetary consequences.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Break away valve'.

assistant: **Innovation**

If you forget to take away the nozzle, when you have filled fuel in the tank of your car - a disaster may happen! These drive away accidents happens almost every day! Normally the nozzle hooks in your car and pulls away parts of the pump and damage the dispenser. Then it goes on throwing out 40 - 200 litters of fuel per minute creating very large hazards of explosions, fires, personal injuries and environmental damages. About 20 % of the dispensers in Europe are equipped with safe break devices. But most of these devices have disadvantages that impede them from protecting you. They are sensitive to corrosion from the fuel and affection from different weather conditions. This results often in malfunctions and a very short life time. Even if there is a safe break on the dispenser, the probability of malfunction is high. The authorities work with regulations for safe breaks - the CEN 221 standard is foreseen to be ready in 1998. The State-of-the-Art is that no safe break system on the market stands up with the requirements of this standard. The proposers in this project cooperate to develop a new type of safe break device, which will be applicable on different types of liquid dispenser systems - with or without sigth glass, coaxial or standard hose - and in accordance with the CEN 221 standard. The overall economic objective is that the new type of safe break device can be produced at a cost, which is less than 50 % compared to the State-of-the-Art. But in this developing project we have not been able to achieve acceptable solutions - the problems are more difficult than you think. for As we are SMEs with limited know-how we must engage external experts, who will by RTD try to solve the problem in cooperation with us. The overall objective of this research project is to in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strategies for public transport in cities', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SPUTNIC builds on the outcome of the VOYAGER project and pays special attention to PT-related challenges in the New Member States. While the VOYAGER project aimed at general analysis and provided overall recommendations, SPUTNIC will take up the most urgent challenges identified and provide more specific guidance. SPUTNIC will help PT actors and decision makers to shape PT into an attractive and efficient mode of urban transport.SPUTNIC will:- Support key stakeholders anticipating and preparing for emerging challenges in the field of urban mobility;- Provide an updated overview of state of the art knowledge and research results in the area of urban mobility and public transport;- Collect available best practices in and assess their transferability to enable sector-internal learning from advanced experience;- Present specific guidelines and tools to benefit from best practices identified throughout European regions and cities;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Deciphering the role of surface mechanics during cell division' (MitoMeChAnics).

assistant: **Concept**

Cell division is fundamental for all life forms and its dysregulation can lead to severe diseases including cancer. The dramatic shape changes eukaryotic cells have to undergo to divide are mostly driven by the cell surface, a complex system that can dynamically modify its mechanical properties. While the importance of physical cues for cell division has long been recognized, the lack of specific tools that modify particular physical properties and bridge molecular-to-cellular scale biophysics prevent us from understanding how cells use their mechanics to regulate form and function. To address this, my group has recently developed a new class of molecular tools that for the first time allows us to manipulate surface mechanics specifically and acutely in living cells. Exploiting this powerful new structural biophysics approach, our first discoveries excitingly demonstrate that the strength of tethering between the plasma membrane and the cortical cytoskeleton is a key control mechanism for cell division, both in cultured cells as well as in mouse embryos.The overarching goal of MitoMeChAnics is to systematically understand how cell surface mechanics controls the different steps of division. My team and I will systematically and quantitatively link cell surface architecture with the resulting mechanics and morphology to determine the structure-function relationship at the cellular periphery in space and time. To this end, we will deploy novel molecular tools and combine them with cellular biophysical measurements, super resolution microscopy and in situ cryo-electron tomography. Moreover, we will build data-driven theoretical models to unravel the physical principles that control the membrane-cortex interface, and test their predictions with novel optogenetic tools. Our p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Connections between string theory and non-commutative geometry' under Fifth Framework.

assistant: **Concept**

I intend to use, in the context of D-brane physics in general backgrounds, techniques of non-commutative geometry for the understanding of problems of off- shell string physics and to study this way the non- local nature of string field theory actions.