RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Specific Fluorogenic Peptides for Imaging Metastasis-associated Macrophages'.

assistant: **Innovation**

MACROIMAGING is a highly interdisciplinary project encompassing the preparation and optimisation of innovative fluorogenic imaging tools with high selectivity for metastasis-associated macrophages.The metastatic potential of tumours is defined by the tumour microenvironment (TM), where macrophages are the most abundant cells. However, the role of macrophages in the TM remains elusive mainly because of the lack of technologies to target these unique populations of cells in vivo. CD11b+ metastasis-associated macrophages are recruited by metastasing cancer cells. Their depletion reduces the number and size of metastasis, suggesting that their recruitment is essential for persistent growth of cancer cells. However, there is a need for imaging tools that report the localisation and cell fate of these macrophages to understand how they help tumour cells to progress in the TM.By means of Dynamic Combinatorial Chemistry, libraries of cyclic peptides will be generated from individual tetrapeptides through reversible disulfide bonds. Governed by thermodynamics, DCC will amplify cyclic peptides showing high affinity for CD11b+ macrophage receptors, involved in the development of metastasis. This technique will supply specific cyclic peptides targeting CD11b. Click chemistry (i.e. CuAAC) will allow the conjugation of these peptides to macrophage-specific fluorophores to generate FLUOROMACS. FLUOROMACS will enable selective imaging of CD11b+ macrophages by means of receptor-mediated endocytosis. Selectivity will be confirmed in vitro using macrophages from normal cohorts and knockouts. Finally Fluoromacs will be optimised as in vivo imaging probes for metastasis-associated macrophages.In a nutshell, MACROIMAGING will provide the first generation of chemical probes for imaging metast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Autonomous aerial inspection of GNSS-denied and confined critical infrastructures' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The >50k large vessels across the world must be regularly monitored for corrosion and defects by human surveyors, including dangerous and dirty confined GNSS-denied areas such as ballast water tanks and cargo holds. One person is killed every week from accidents in these enclosed spaces, which despite having large surface areas, consist of many smaller, confined compartments with narrow passages (40cmx60cm). However, a radical new approach is possible using unmanned aerial systems (UAS or drones), by combining the latest developments in (1) collision-tolerant UAS, (2) multi-modal SLAM, (3) path planning, (4) autonomous drone racing, (5) aerial manipulation, (6) miniaturized NDT sensors, and (7) ML-based defect identification. Only through a complete integration of these technologies is it possible to address the challenges of deploying aerial robots in these challenging conditions. Equipped with automated AI-based scanning, mapping, navigation and contact-based NDT, this has the potential to completely remove the need for human inspection. Using a digital twin approach brings “superhuman” results: comprehensive semantic-aware detailed 3D mapping (1 cm resolution) of large structures (>300 m), high resolution visual and NDT analysis (100um) and improved traceability with automatically generated trend analysis. The ML for system mapping and NDT is trained with sociotechnical inputs from experienced human inspectors.Currently, a typical inspection costs >1M€ and requires 15 days (8 days inspection and 7 days travel to low cost Far Eastern docks). A UAS-based inspection will take 1 day, with 1-2 days travel to an EU port at a cost of 200k€, saving the industry >9B€ p.a. with 2.4MT of CO2 reduction. This consortium includes many of the world leaders in the field of UAS-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Om partners/computer aided software testing' in the context of a Fourth Framework call.

assistant: **Objectives**

Our software systems are becoming more and more important for the daily operation of our customers. It is therefore necessary to deliver extremely reliable and stable software. On top of this, a rapidly evolving environment necessitates short time to market cycles. In this context, automated software testing provides a way to perform tests more consistently and more systematically.The objective of our experiment is therefore to increase software reliability and stability, and shorten time to market cycles for our generic modules. We want to decrease the time spent providing customer support solving software anomalies. This will allow us to implement a great product variety without loss of reliability.THE EXPERIMENTThe experiment will consist of the following actions:Market survey, selection and acquisition of a software testing toolInstallation of a measurement methodSet-up of the test environmentExperiment with change management of the testing environment in the light of software evolutions (releases)The development process of our OMP/Master Production Scheduling software will be used as a baseline project. This system runs on a database, and is strongly oriented towards its graphical user interface. It consists of approximately 200.000 lines of C-code, some of which is shared with other products.EXPECTED IMPACT AND EXPERIENCEOM Partners n.v. expects to be able to increase even further its software quality while shortening the time to market of new releases. We intend to decrease the time spent on customer support due to software anomalies, while providing a large product customisability. This will be obtained thanks to a reduction of the time spent on executing a test session, resulting in higher test frequency.After finishing the experiment, we foresee the applicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Intelligent management system for integrated multi-trophic aquaculture'.

assistant: **Innovation**

The Integrated Multi-Trophic Aquaculture (IMTA) is acknowledged as a promising solution for the sustainable development of aquaculture. However, IMTA has been only tested at very small scale in Europe, while management of large-scale IMTA areas remains difficult.The high level ambition of Impaqt project is to drive a paradigm shift in the EU Industry and its , paving the way to both a more environmentally friendly and more efficient/higher yielding European Industry. To that respect, Impaqt proposes an intelligent management platform for IMTA. Impaqt will develop and deploy novel sensors and data sources, together with smart systems required for long term autonomous monitoring in the field. An advanced IMTA model will be provided which yields spatially explicit information on how the different farm components interact with the environment on the scale of an ecosystem and that can be used for planning decisions by both farmers and regulators. Last but not least, an integrated management system, operating at the scale of an IMTA farm and comprising analytics and decision support functionalities, will be developed to enable enhanced operational decisions for animal welfare, production optimization, environmental protection and food quality assessment.Impaqt systems and models will be validated in 6 pilots (Scotland, The Netherlands, Ireland, Turkey and China), addressing inland, coastal and offshore aquaculture. Impaqt will demonstrate the eco-intensification of EU aquaculture, by demonstrating the eco-efficiency and the environmental impacts minimized, the socioeconomic benefits and ecosystem services enabled, as well as the transition towards a circular economy business model. Impaqt brings together a considerable range of partners including 14 academic/research organiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decision support for large scale integration of wind power' under Sixth Framework.

assistant: **Concept**

The project has the following objectives:- Demonstrate the applicability of decision support tools based on stochastic analysis and programming for operational management of grids and power plants- Demonstrate the applicability of strategic analysis tools for decision support for long-term management of grids- Detailed analysis of improved coordination mechanisms between grid operators, power plant operators, power exchanges etc.Based on the planning tool developed in the WILMAR project, a set of tools is developed which support Transmission System Operators (TSOs) and other stakeholders in their operational and strategic decision making related to the integration of high shares of wind or other fluctuating renewables. More specifically the evaluation of regional and trans-national transmission line investments caused by large scale introduction of wind power will be analysed in detail.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel photo-assisted systems for direct Solar-driven redUctioN of CO2 to energy rich CHEMicals' (SUN2CHEM).

assistant: **Innovation**

Gathering 15 partners from 9 European and associated countries and 3 from Asian countries, SUN2CHEM’s main objective is to develop solutions to achieve efficient solar-driven CO2 reduction, targeting ethylene as the final product. Ethylene, an energy-rich chemical produced from fossil fuels in industry, has both high commercial value and a giant global market. SUNCHEM’s ambitions will simultaneously reduce our dependence on fossil fuels and mitigate carbon emission by CO2 conversion. For that purpose, SUN2CHEM partners will conjointly develop all the components to be integrated into tandem photoelectrochemical (PEC) cells and advanced photocatalytic (PC) reactors. The technical part of this project includes applied and fundamental research on photocatalysis to improve light-harvesting and charge separation in heterojunctions and plasmonic bimetallic nanoparticles united in a PC reactor (WP2). Next WPs focus on the development of up-scalable efficient and stable photoelectrodes (WP3) and the design of earth-abundant catalysts (WP4), which will then be integrated into the tandem PEC (WP5). Both PC reactor and PEC device will be tested and characterised in operating conditions (WP6). In addition to this highly technical core, this project has for ambition to perform related environmental and social studies in order to integrate the developed technology within a context of circular economy, assess the energy security impacts on end-users and increase the social acceptance of chemicals produced from sunlight conversion (WP7). A prospective market analysis and roadmap towards the upscaling of the technology will then evaluate its medium-term potential and establish pathways towards its future industrial development (WP8). Achieving these ambitious developments by tackling pho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A Novel Eco-Friendly, dually Efficient and Resistance-free Treatment of vaginITIs'.

assistant: **Concept**

Bacterial vaginosis (BV) and vulvovaginal candidiasis (VCC) are common vaginal infections caused by Gardnerella and other anaerobic bacteria. or by Candida fungi. The infection can occur once - the acute form - or recur repeatedly over the course of a year. About 68m women in Europe and the US are infected each year. They cause intense physical discomfort, adversely affects quality of life and have heavy socioeconomic costs. Many women opt to self-treat with non-prescription over-the-counter antifungals which fail because the causative microorganism has not been properly identified. Antibiotics for BV are encountering increasing levels of drug resistance. Combination of misdiagnosis, misuse, non-compliance, overconsumption leads to low efficacy and high recurrence rates for both VVC and BV.NEFERTITI FTI will demonstrate in clinical trials a pessary based on glucono-δ-lactone –trademarked as pHyph - as a highly effective cure for acute and recurrent BV and VVC, and as a far better alternative to antibiotics or antifungals. pHyph restores the vaginal mucosa to pH4 and disrupts Candida biofilms, promotes the proliferation of natural and protective aerobic lactobacilli, and displaces Gardnerella and other anaerobic pathogenic bacteria. pHyph is a single solution for both pathogens and infections, and with both curative and protective effects, and does not trigger drug resistance in the microbiome. These features are unmatched by any other product on the market – whether as over the counter or prescribed. NEFERTITI FTI will also develop a post-project business plan for the rapid scale up of production and commercialisation of pHyph in Europe in 2022 as an over-the-counter product into a market for BV and VVC treatments worth €1.7bn in 2022 and will be commercialised through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'SINGle-cell mapping of  Living kidney donation for the  Assessment of Renal adaptation'.

assistant: **Innovation**

>850 million people are affected by kidney disease, which is caused by kidney injury. Following injury, kidney cells have a remarkable ability to adapt. Previous studies have largely focused on kidney injury signatures, yet treatments successfully targeting injury in animals have failed in humans. Studies focused not on injury but on adaptation are lacking. The main reason for this is that studying kidney adaptation with existing methods is challenging due to the low signal-to-noise ratio of adaptation in the presence of injury.Instead of studying adaptation in kidney injury patients, SINGuLAR will therefore study isolated adaptation in living kidney donors: Donors, who irreversibly lose 50% of their kidney mass and function, show astonishing compensatory growth and functional adaptation. Studying the remaining kidney after contralateral organ loss allows to leverage an unbiased system free from injury-related noise.Since tissue biopsies from remaining kidneys that adapt well put living donors at disproportionately high risk, SINGuLAR will use renal cells shed into urine to create the first prospective single-cell transcriptomic map of kidney adaptation (Aim1). Additionally, we will investigate whether remaining kidney adaptation is epigenetically wired (Aim2) and how this process is spatiotemporally patterned (Aim3). SINGuLAR will also assess whether multi-omic data from remaining kidneys in donors correlate with outcomes of donated partner organs in recipients (Aim4), and it will leverage urine-derived tubuloids to enable patient-specific drug targeting (Aim5).By employing the remaining kidney as a one-of-a-kind human model, SINGuLAR aims to obtain unprecedented spatiotemporal insights into the biology of kidney adaptation and compensatory growth, which can subsequent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chromatin 3D Structure of Archaic Human Populations and Its Impact on Modern Human Genomes' (ARCH-3D).

assistant: **Innovation**

Most people alive today carry genetic material inherited from ancient hominins like Neanderthals or Denisovans. This introgression has shaped traits such as immunity, skin pigmentation, and disease susceptibility, yet the precise genetic mechanisms behind these influences remain unclear. Understanding how this archaic DNA continues to affect modern human biology could unlock new insights into both human uniqueness and diversity. While advances have been made in understanding the 3D structure of the genome and how genes are regulated spatially, the role of archaic DNA in these processes remains not fully understood. ARCH-3D aims to address this by constructing the first 3D models of Neanderthal and Denisovan genomes, offering a groundbreaking view of their spatial organisation. By comparing these models to modern human genomes, ARCH-3D will explore how introgressed regions influence gene regulation and contribute to human diversity. These regions may also reveal new targets for drug development, providing a practical application of the findings. Based at the McDonald Institute for Archaeological Research (MIAR) at the University of Cambridge, ARCH-3D will be conducted under the supervision of Dr. Guy Jacobs, an expert in human population genetics and archaic introgression. MIAR’s interdisciplinary environment, with its focus on human evolutionary genetics and archaeology, will provide invaluable resources for the computational analysis and interpretation of results in an evolutionary context. Dr. Wlasnowolski will also receive comprehensive training in cutting-edge computational techniques and interdisciplinary research, enhancing his academic career prospects. This experience will prepare him for roles in industries such as drug development, where understanding genetic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European network for forensic handwriting experts' under Fourth Framework.

assistant: **Concept**

Background:Handwriting examination or identification is frequently used in crime investigation and in the prosecution and conviction of criminal offenders. Increasing collaboration between the European forensic science institutes has led to a greater need for harmonisation of their working methods and techniques. Delegates from the forensic science institutes of Germany, England, Finland, The Netherlands, Northern Ireland, Norway, Portugal, Scotland and Sweden have therefore taken the initiative to form a European Network of Forensic Handwriting Experts (ENFHEX), specifying a number of objectives to achieve the desired harmonisation and validation of handwriting identification procedures.Objectives:The main objectives are to create an infrastructure for internal communication; to bring together and make available databases of:1) literature on handwriting examination and adjacent disciplines;2) handwriting samples and;3) copybook models used in various countries in different periods; to survey and evaluate methods and procedures to help harmonise working practices; to survey ongoing and projected R&D projects in order to co-ordinate efforts and prevent unintended duplication; to work out a procedure for running European quality assessment trials (proficiency tests); to organise mutual three day working visits of groups of handwriting experts from the participating institutes (exchange of expertise); to publish a bulletin; and to organise the biennial European Conference for Police and Government Handwriting Experts.Work programme:The Standing Committee of ENFHEX, consisting of delegates from forensic science institutes from the above-mentioned European countries, has divided the tasks among its members. Members will report and discuss activities at ENFHEX meetings, which