RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Massive parallel de novo design of sensing nanopores' in the context of a Horizon Europe call.

assistant: **Objectives**

Proteins embedded in membranes play key roles in maintaining cell integrity, homeostasis and communication. Emerging technologies (nanopore sequencing, synthetic cells, …) imitate biological systems and repurpose membrane protein for the transport and sensing of new analytes through synthetic membranes. These applications have fuelled the demand for (synthetic) membrane proteins with properties and functions not observed in nature. Structure-based computational protein design is revolutionizing many aspects of biotechnology but has almost exclusively focused on protein folding in water. The aim of PoreMADNeSS is to develop innovative strategies to enable the design of transmembrane β-barrels (TMBs), a class of membrane proteins with excellent properties to act as nanopore sensors. Using multidisciplinary approaches, we will address basic biophysical knowledge gaps that currently limit TMB design. The design of TMB folding in synthetic membranes gives access to a wealth of TMB sequences and structures not sampled by nature because of constraints associated with biogenesis and with the composition of biomembranes. We propose a combination of massive parallel de novo design and adaptive machine learning to explore this unknown TMB space, to gain crucial insight into the determinants of TMB folding and to develop robust design methods. As a proof-of-concept, PoreMADNeSS will focus on the design of steroid sensing nanopores. Our strategy is to design a cortisol binding site across the transmembrane channel, which would act as the reading head for single molecule fingerprinting. My lab was first to demonstrate the feasibility of TMB design and has established a design pipeline from computation to electrophysiology and biochemical characterization. This project has all the com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Simulator for Moving Target Indicator System' (SIMTISYS).

assistant: **Innovation**

Within the framework of the FP7 3° call several policies are related to the maritime surveillance for safety purposes as border surveillance, traffic safety, fishery control and environmental protection and monitoring (i.e. sea platform infrastructures and sea ports).Within all these policies the detection and the tracking of small vessels assumes a central strategic issue. A common tool, useful for monitoring the maritime borders and in particular maritime routings and traffic and the management of pollution, is proposed. In this program a Simulator for a Moving Target Indication System will be implemented. The heritage of the FP7 2° call is taken into account concerning the Operational Scenarios, the EU Techniques and Technologies and possible contributions from planned or on-going Space Missions. The SIMTISYS program will assure to the European Service Providers a useful and powerful tool for detection and tracking of small vessel in defined Scenarios.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and validation of hybrid propulsion system components and sub-systems for electrical aircraft' (HYPSTAIR).

assistant: **Innovation**

The HYPSTAIR project concerns the design of components of a serial hybrid propulsion system for small aircraft. A serial hybrid aircraft concept currently represents the best efficiency versus range compromise in the light aviation segment. It can be considered as an electrically powered aircraft, with an on board generator used for extending the range when necessary. Limitations of current electric energy storage technology make an electric-only propulsion system as yet unsuitable for long range flying, therefore an on board ICE generator provides a weight efficient, if somewhat less energy efficient, power generation solution.The project will involve conceptual design of the hybrid propulsion system components, namely the generator, motor, inverter, batteries and control unit. The components will be sized and designed by considering the performance and energy efficiency of the complete airframe-propulsion system, and will be tested in a laboratory environment. A dedicated human-machine interface will be designed that will allow simple operation of a complex hybrid system. Together with the reliability of electrical motors and the use of dual energy sources, safety of flying as provided by a system built upon these components will be improved.All components will be designed in a way that they will meet the relevant safety and certification standards. As there currently exist no regulations for aviation hybrid drive systems, defining these in collaboration with the authorities will be an important contribution of the project, paving the way for hybrid and electric technologies to be introduced to the market. These efforts will help create a competitive supply chain for hybrid drive components and reduce the time to market of such innovations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LOW valued energy sources UPgrading for buildings and industry uses' (LOWUP).

assistant: **Innovation**

In the “secure, clean and efficient energy” initiative, it is stated that the most important milestones for such a transformation are the EU's energy and climate targets for 2030, which are: (i) at least 40% reduction in greenhouse gas emissions compared to 1990, (ii) at least 27% for the share of renewable energy consumed in the EU, and (iii) at least 27% improvement of energy efficiency and an electricity interconnection target of 10%[1].The LowUP Project has a two-fold strategy: 1) on one hand, to target goals (i) and (ii) of these climate challenge with a 42 months duration project where innovation will be the core activity, and 2), on other hand, to successfully present different  technological solutions which will enable the participation of low grade thermal energy sources in the energy transition, and improve the efficiency of the Europe Low Exergy systems, not only at building level but also in industrial applications. Within the LowUP project three different heating and cooling systems will be developed and demonstrated at relevant environment: HEAT-LowUP (low exergy heating system directly fed by solar and sewage water recovered heat) COOL-LowUP (low exergy cooling systems directly fed by renewable and free energy sources) and HP-LowUP ( waste heat recovery and upgrading via heat pump.) The first two systems are focused on the rational and efficient use of low valued energy sources for direct implementation in low-exergy heating & cooling systems for buildings and the third one is focused on the exploitation of low temperature residual energy, wasted with industrial processes, by upgrading them to generate useful heat to be re-introduced in the process.The project will be implemented using the Acciona thermal lab located in Seville where will be emulated diff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Unraveling the cellular sulfenome: a search for new redox-regulated pathways'.

assistant: **Objectives**

Within proteins, cysteine residues are sensitive to oxidation by reactive oxygen species (ROS). The first oxidation product of cysteines exposed to ROS is the sulfenic acid derivative (-SOH). Sulfenic acids are highly reactive intermediates that, unless they are stabilized within the protein microenvironment, react with another cysteine present in the vicinity to form a disulfide or are further oxidized to the irreversible sulfinic (-SO2H) and sulfonic (-SO3H) acid modifications. Sulfenic acid formation has traditionally been viewed as an unwanted reaction opening the way to damages that are harmful to proteins. However, it has become clear in recent years that formation of sulfenic acids is not always deleterious to the cell. A new concept is emerging, in which sulfenylation of specific cysteine residues modulates signal transduction pathways by altering the activity and function of cellular proteins, just as phosphorylation and dephosphorylation cycles regulate enzyme activities and cellular pathways. However, the modulation of protein function by sulfenic acid formation has been unambiguously shown for only a few proteins. We postulate that specific oxidation of cysteine residues via sulfenylation modulates the activity of many more proteins and pathways and that numerous sulfenylation sites have not yet been recognized. We want to apply an unprecedented multi-facetted approach to fully grasp the physiological scope of cysteine sulfenic acid formation by uncovering the sulfenome of a living organism, using Escherichia coli as a model. The main objectives of our research program are (1) to comprehensively characterize the sulfenome of E. coli, 2) to identify new proteins and pathways regulated by sulfenylation and (3) to understand how sulfenyla-tion is controlled at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'AN INNOVATIVE COLLABORATIVE CIRCULAR FOOD SYSTEM TO REDUCE FOOD WASTE AND LOSSES IN THE AGRI-FOOD CHAIN' (FOODRUS).

assistant: **Innovation**

It is evident that current food supply chains are notoriously inefficient and show vulnerabilities from initial agriculture production down to the final household consumption and the management of the waste generated.FoodRUs strategy has been built on the basis of the three fundamental pillars of food sovereignty  to undertake Food Waste Prevention challenge being Circular Economy a mandatory model from which to generate, implement and replicate solutions, in different value chains. The reasoned application of these basic principles where FoodRUs strategy is applied, will assure resilient and sustainable local and regional Bioecosystems thanks to a multi-actor and multidisciplinary approach.FoodRUs will deployed 23 technological, social, financial, legal, educational, political, labelling and organizational innovative solutions involving the mobilization and active participation of more than 40 actors to overcome the specific challenges of the selected value chains and follower regions consisting on: experts on agro-industry, Life Cycle Assessment , social innovation and social economy, sensitisation , culinary arts, nutrition, labelling, fiscality and ICT tools; municipalities; policy makers; ethical finance organizations, stakeholders of the entire food value chains (producers, farmers, retailers, packaging and logistics services, restoration sector, consumers associations and communities); waste managers; entrepreneurs; ONGs; food banks; social kitchens; educational centres and civil associations. FoodRUs will screen 3 value chains focused on 3 specific types of food in Europe: -Cross-regional Spanish pilot (SPP) focused on vegetables and IV range salads -Danish pilot (DP) that will analyse the value chain for meat and fish -Slovak pilot (SLP) analysing the bread val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Machine Learning and Mass Spectrometry for Structural Elucidation of Novel Toxic Chemicals' in the context of a Horizon Europe call.

assistant: **Objectives**

Nearly half a million known chemicals have been deemed relevant for exposure studies and an even larger number of their transformation products are likely to co-occur in the environment. This mind-blowing number of possible chemical structures makes it impossible to in-silico generate all these structures, let alone synthesise and analytically confirm them, thereby limiting the discovery of novel chemicals. Today, the structural elucidation of chemicals detected with high resolution mass spectrometry relies on databases and machine learning models trained on the known chemical space. Both are fundamentally ill-suited for discovering novel chemical structures. As a result, only a few percent of the toxic activity of the environmental samples is explained by the currently known and monitored chemicals. It is crucial to access the novel chemical space to improve our understanding of the origin, fate, and impact of these chemicals. The aim of LearningStructurE is to turn the discovery of novel chemical structures from serendipity to routine. As a steppingstone in this pursuit, I will combine the fundamental understanding of chromatography and high resolution mass spectrometry with machine learning to pinpoint novel toxic chemical structures based on their empirical analytical information. To significantly advance the predictive power of machine learning models for empirical analytical information, I will take advantage of the candidate structures as a sample specific training set for machine learning models. The improved predictive power will feed into in-silico structure generation, allowing to elucidate the structure directly from the empirical analytical information. LearningStructurE will pave the way for exploration of the unknown chemical space detected from environme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Some Problems in Geometry of Shimura Varieties' (SPGSV), addressing dissemination and exploitation.

assistant: **Impact**

The Andre-Oort conjecture is an important problem in the theory of Shimura varieties. It also has significant applications in other areas of Number Theory, such as transcendence theory. The conjecture was proved assuming the Generalised Riemann Hypothesis by Klingler, Ullmo and Yafaev. Very recently, Jonathan Pila came up with a very promising strategy for proving the Andre-Oort conjecture unconditionally. The first main aim of this proposal is to combine Pila's ideas with the ideas of Klingler-Ullmo-Yafaev in order to obtain a proof of the Andre-Oort conjecture without the assumption of the GRH. We then propose to use these methods to attack the Zilber-Pink conjecture, a very vast generalisation of Andre-Oort. We also propose to consider several problems closely related to geometry of Shimura Varieties and the Andr\'e-Oort conjecture. Namely Coleman's cponjecture on finiteness of the number of Jacobians with complex multiplication for curves of large genus, the Mumford-Tate conjecture on Galois representations attached to abelian varieties over number field and Lang's conjecture on rational points on hyperbolic varieties in the context of Shimura varieties.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quality assurance and structural evaluation of GRP pipes' in the context of a Sixth Framework call.

assistant: **Objectives**

Over 10 million kilometres of pipelines in European transport hazardous fluids, of which over half are carrying hydrocarbons (i.e. oil, oil derivatives and gas). Only a very small number of these pipelines are made from corrosion resistant GRP materials, with the vast majority of pipelines being fabricated from steel pipes joined together by butt welds.Steel pipelines are prone to corrode over a period of time and are therefore likely to leak hydrocarbon products into the environment. For use in ambient temperatures and relatively low pressure applications, GRP would offer an attractive alternative to steel were it not the fact that the integrity of the interconnecting pipe joints cannot be inspected with a high level of confidence.The inadequacy of conventional NOT techniques seriously limits the current applications of GRP pipelines and furthermore the joint needs to be 'over wrapped' to provide a secondary containment in event that the primary joint is defective. If suitable NOT methods can be developed, GRP pipe would be used in additional applications pipeline that cannot be currently considered as viable. The consortium SME partners propose to develop new and novel Non Destructive Evaluation (NDE) techniques, sensors and systems that are capable of assessing the quality assurance and structural integrity of 'production' and 'in-service' GRP pipes and pipe joints.Hence this key enabling technology will facilitate the use of GRP materials without the need for cost prohibitive over engineering processes such as secondary containment 'over-wrap'. The highly reliable and sensitive NOT methods developed under this proposal will also extend the use of GRP pipe into other applications that have traditionally been the domain of corrosion prone metallics that have resulted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimization of photo-refractive optical components for information technologies' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

On this basis the work of the first assessment phase will be given a threefold objective in order to- explore more fully the photorefractive behaviour of vanadium-doped CdTe crystals by varying key parameters;- demonstrate the use of such crystals in some specific applications;- attract industrials intended to join the full-scale project as proposers or advisers.The first part of the work programme will involve coordinated efforts on crystal growth, chemical and physical characterisation, optical measurements. The variation of a key parameter -the vanadium to compensating centres ratio- will allow one to specify the photorefractive effect related to vanadium incorporation. Wave-mixing experiments including time and temperature dependences will be carried out and interpreted using theoretical modelling and computer simulation.In parallel typical applications will be investigated in the field of optical transmission at 1.3 - 1.55(m. This wavelength range is of particular importance for low losses optical fibre transmission and also for free space interconnection (eye-safe wavelengths). Firstly a method for determining the coherence function and emission spectra of semiconductor lasers using a two-wave mixing configuration will be demonstrated. Secondly preliminary experiments will be performed on phase conjugate mirrors as a technique for adaptive coupling of a laser beam into an optical fibre and switching from multiple sources to multiple destinations.The second phase of the project will address more ambitious objectives:- to specify an optimum method of crystal growth leading to device-quality photorefractive II-VI crystals covering the most useful wavelengths;- to realise prototype components intended to be inserted in optical networks;- to enlarge the field of applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mobile software and services, Standardisation, Quality, Interoperability, Testing, Open source' (MOSQUITO) targeting Seventh Framework.

assistant: **Abstract**

Internet is going to be massively mobile". The efficient and growing internet of services has also to take into account issues of this "mobility" as well as the mobile devices and their applications. If, at the origin, mobile internet solutions depended on the power of mobile operators, today the take-off of the iPhone and its application-platform "Appstore" upset the balance of the forces. The future of Mobile Internet of services is more and more about mobile applicationsThe mobile application business however is plagued by a critical and recurrent issue: Fragmentation has an extremely large number of origins and the causes of fragmentation are not fully understood in detail. Fragmentation is striking standards based mobiles platforms more severely than proprietary. How sensitive mobile application markets are against fragmentation is definitely an insufficiently documented topic. At present, without disruption, the forces of the market are likely to make the mobile application ecosystem evolve in one of three directions: (i) One takes all. There is nothing but a single application platform surviving the fragmentation. That would have dramatic consequences on many economical sectors. (ii) As a variant, few non-interoperable application platforms would survive. (iii) The mobile Internet of services just does not happen. Because fragmentation remains at an unacceptable level, innovation and service just do not reach the consumers.The Mosquito project will provide key and focussed support mainly to overcome mobile application fragmentation which prevent taking full benefit of the development of internet of services that current technology such as 3G, Wireless and future 4G (LTE, Wimax) should permit. To overcome fragmentation, an important task would be to document all i