RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'T cell-driven inflammatory mechanisms promote recovery after acute brain injury', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The overall goal of this project is to investigate T cells as “Trojan horses” to improve recovery from brain injuries – we will gain novel insights on how T cells promote neurologic recovery by modulating the cerebral micromilieu and how these pathomechanisms can be therapeutically targeted. Inflammation is a common response to acute brain injuries, which are a leading cause of morbidity and mortality. I have recently identified continuous cerebral T cell recruitment as a hallmark of a long-lasting and profound neuroinflammation after acute brain injury. While a detrimental effect of T cells in the acute phase has been well documented, the pathophysiological consequences and therapeutic potential of T cell-driven chronic inflammation for recovery after brain injury are unknown. Interestingly, my recent findings indicate that T cell fate is orchestrated in the gut via modulation of commensal bacteria and that T cells potently promote stroke recovery. Building up on these recent findings, I hypothesize that T cells contribute substantially to the recovery after brain injury by inflammation-driven remodeling. Using several innovative methodologies applied for the first time to recovery after brain injury, we will firstly investigate the contribution of T cells on cortical connectivity, spine plasticity and mechanisms of glial responses. Next, we will analyze the contribution of the gut microbiota to modulate the chronic neuroinflammatory response via a pro-regenerative polarization of T helper cells. Finally, we will test the generalizability and translational robustness of our findings in models of various acute brain injuries and common comorbidities. Results from this project are likely to open up a new research field on T cell-driven neurologic recovery after brain inj
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Unveiling galaxy assembly from next generation photometry' to be submitted under Seventh Framework.

assistant: **Abstract**

The primary goal of this project is to develop a new type of statistical approach to constrain the assembly of the evolving population of galaxies over cosmic time using modern multi-waveband photometric surveys. This work combines uniquely the expertise of: (1) the proposed fellow, in the development and application of state-of-the-art statistical techniques to interpret galaxy spectral energy distributions (SEDs); (2) the host scientist, in the development of sophisticated models to describe the integrated light emitted by stellar populations; (3) the science team of the TERAPIX data reduction centre of the host institution, which manages archives of two of the biggest multiwavelength photometric surveys to date - the Cosmic Evolution Survey (COSMOS) and the Canada-France-Hawaii-Telescope Legacy Survey (CFHTLS).   The method will employ modern multivariate analysis techniques to create photometric “indices” which describe in a compact way the entire SED of a galaxy, independent of redshift. Replacing traditional colour-colour diagrams with such indices will enable a powerful combination of the methods of SED-fitting and diagnostic diagrams of star formation and chemical enrichment history. We will, for the first time, be able to identify and extract the information encoded in the full SEDs of galaxies for entire galaxy populations. By applying the new method to the world leading photometric dataset, COSMOS, we will gain unprecedented insight into timely cosmological issues such as the assembly history and chemical enrichment history of galaxies as a function of stellar mass, and the link between galaxy mergers, star formation and black hole activity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bridging the Gap between Europe and India?s Nanotechnology Knowledge Bases towards an understanding of Innovative Support Structures, Training Programmes and Policies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Recently, the EU decided to forge partnerships with India in its 20 billion euro research and technology development programme. It has identified nanotechnology and nanosciences for Indian participation. As part of the EU FP6 Programme for R#Amp;D, Indian scientists will be encouraged to participate intensely in various research programmes. Nanotechnology is emerging as one of the key technologies of the 21st Century and is expected to enable developments across a wide range of sectors that can benefit citizens and improve industrial competitiveness.It is imperative that more projects are set into motion, engaging key institutions, scientists, civil society, policy makers and others from both sides involved in the nanosciences and nanotechnology to share and exchange information. This project acts as an adhesive in direct response to the European Union's partnership with India. The proposed EuroIndiaNanoNet project brings together a consortium of highly accredited institutions from Europe and India and provides a medium for discussions between stakeholders on various issues of nanotechnology.In particular, this project's main aim is to study the mechanisms in India that foster innovation in the nanosciences and nanotechnologies. These mechanisms will include training programmes, support structures and policies. An in-depth study will be developed to help create an understanding of the Indian nanotechnology and nanosciences areas and to better position the EU and India's scientific research goals in this area.The project will create a EU-India cross-border platform strategy implementation plan, which will outline an approach for establishing further nanotechnology research collaborations between India and the EU. The networking of key EU and Indian stakeholders is paramo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Fostering the practical implementation of Open Science in Horizon 2020 and beyond' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

The FOSTER+ project will focus on promoting the practical implementation of Open Science, with activities targeting academic staff, young scientists and policy-makers in particular. Building on the existing FOSTER portal and training materials, FOSTER+ will develop more advanced-level and discipline-specific materials that build capacity for the practical adoption of Open Science and promote a change in culture. Disciplinary partners in the life sciences, social sciences and humanities will tailor training content to the practices of each domain. Over 50 training events will be delivered, reaching over 4,500 participants. Workshops will be outcome-oriented, providing participants with tangible skills, such as selecting relevant repositories, understanding how to license research data, and negotiating EU data protection laws.FOSTER+ will develop a multi-module Open Science Toolkit, covering key topics such as responsible research and innovation, research data management, software carpentry, text and data mining, reproducible research and open peer review. E-learning courses will be delivered for each module via the Learning Management System and materials will be made available to support face-to-face training delivery. The Open Science Trainer Bootcamp will convene a cohort of trainers with high multiplier potential and equip them to deliver courses within their institution/disciplines. The Bootcamp will be open to both researchers and intermediaries who provide the research environment and infrastructure to support open science. Gamification tools will incentivise the trainer network to add new content to the portal and run more innovative events. Enhancements to content maps and learning structures will enable individualised learning pathways to be recommended to user
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 're-conceptualize shopping malls from consumerism to energy conservation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

CommONEnergy focuses on existing shopping malls to be refurbished and buildings with a different original function, redesigned to become shopping malls. Wholesales&Retail buildings represent 28% of the total non-residential building stock (BPIE, 2010), accounting for approximately 157 Mtoe in 2005 (EU EEAP). Considering typical shopping malls high impact on modern society (ICSC, 2008), the project addresses their transformation as lighthouses of energy efficient architectures and systems as well as assessment transparency.CommONEnergy has the objective to re-conceptualize shopping malls through deep retrofitting, develop a systemic approach made of technologies and solution sets as well as methods and tools to support their implementation and to assess their impact in a life cycle approach. The main concept to advance the state-of-the-art is the shift from single-action refurbishment to deep retrofitting, with a systemic performance-driven approach including: integrated design process guidelines, integrative modelling environment, energy-economic evaluation tools, lean construction and management procedures, continuous commissioning approach, environmental and socio-cultural impact assessment.The Systemic Retrofitting Approach (SRA) allows to achieve the foreseen targets: up to factor 4 reduction of energy demand, power peaks shaving and 50% increased share of renewable energy source favoured by the intelligent energy management and effective storage. 10 to 20 systemic solution-sets will be developed, demonstrating the widest replication of the cases investigated during the project. These outstanding energy performances will be achieved with short pay-back times (below 7 years) and high indoor environmental quality, with industrial conceptualization of the solutions and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Society and Culture, Climate Change and Environmental Challenges, Health, Artificial Intelligence: DOC'.

assistant: **Concept**

SCHADOC stemmed of regional actors’ will to attract promising Early-Stage Researchers (ESR) to the South-East region of France by offering them an interdisciplinary, intersectoral and international training program of excellence. SCHADOC is an essential building-block in the larger transformation strategy of AMU’s graduate education. It aims to recruit 40 ESRs for 36-month thesis projects. Two calls for candidates will be launched during the first 2 years of the program which will be spread over five years. Applicants will be selected through a rigorous, transparent, open and merit-based selection process, involving various independent national and international experts. The selection process offers the possibility to grant bottom-up thesis projects proposed by the ESR as well as top-down projects proposed to the supervisors. ESRs will follow a training program both on research skills and on non-research oriented transferable skills. They will perform secondments both with a socio-economic and cultural partner and with an international partner. CIVIS alliance will be an asset to implement this international dimension of SCHADOC. This ambitious doctoral training program will improve the employability of the ESRs. Its success will be measured by the excellence of the research projects it will generate in strategic domains for the Region; the partnerships it will develop with the non-academic sector; and the attraction of a large number of international, talented researchers at the Aix-Marseille site. The scientific scope of SCHADOC covers four thematic cross-cutting and interdisciplinary research axes which are in line with the priorities of the SUD Region:- Societies and culture- Climate change and environmental challenges- Health and well-being- Artificial Intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SA.100: Next-generation targeted antibacterial product entering European market', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

According to the WHO, antibiotic resistance is one of humanity’s biggest health threats, claiming ~10 million extra deaths per year and US$100 trillion by 2050, unless alternatives to antibiotics are developed. Micreos has developed the world’s first targeted antibacterial products, set to replace antibiotics. With its endolysin technology, for the first time it is possible to kill only the unwanted bacteria, regardless of resistance. Micreos’ endolysin technology was chosen as Europe’s most relevant Innovation 2018 (Ideas from Europe). Its first lead endolysin, SA.100, kills only Staphylococcus aureus, including the resistant MRSA. Soft-launched under the Gladskin brand in the Netherlands, it’s having life-changing impact for thousands of people with inflammatory skin conditions caused or aggravated by S. aureus, including  eczema, acne, rosacea and Hyper IgE syndrome. Micreos also develops products for diabetic wound infections and a skin cancer triggered by S. aureus. Micreos owns all relevant IP and know-how on its technology and produces its compounds and Gladskin products at small-scale at its facilities in the Netherlands. With this SMEi, Micreos prepares for full roll-out into the EU markets of its SA.100/Gladskin. This includes scale-up of production capacity, strengthening clinical evidence and communication of results to KOLs and relevant stakeholders. Leading pharma and cosmetics companies have expressed interest to in-license Micreos’ technology for particular indications. Relevant markets are the consumer’s skin care market ($177b by 2024; CAGR 4.7%) and dermatology market ($19.8b by 2023; CAGR 9.1%.). Own contribution by Micreos for this SMEi is already secured. This SMEi enables Micreos to take final steps for EU-wide roll-out, driving employment growth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced wheel measuring system for greater rail sector’s profitability' under Horizon 2020.

assistant: **Concept**

The final aim of Wheel Watcher project is to boost the profitability of the railway sector by means of an advanced wheel status monitoring and control system, providing railway operators with accurate and real-time information on wheel wear to drive preventive maintenance actions thus avoiding premature replacement of this equipment.Main industrial impact of the project is to achieve a wheel life increase of 50%, and an increase of 25% of distance between wheel reprofiling actions, allowing the railway operator for conducting a remote but in-depth inspection of wheels. This industrial impact involves a subsequent relevant economic impact, targeting a cost reduction of 25% in maintenance-related costs as a result of less spare wheels and less low value-added works needed.These industrial impacts rely on relevant technical progresses: a high precision mechatronic platform addressing mechanical challenges derived of its wayside placement, a remote measuring unit comprising an ad-hoc thermoelectric cell guaranteeing thermal stability under potential extreme weather conditions, and a novel laser system doubling current power density available, able to measure trains moving at high speeds in outdoor locations, and a user-friendly control software including a self-diagnosis tool. WheelWatcher will have a deep impact on project’s partners, producing an aggregate profit of 23 M€ with more than 35 new jobs expected to be created, and a positive environmental impact due to less CO2 and less scrap.Excellence of the project will allow for dramatic improvements regarding the more relevant challenges faced by railway operators, as compared to the current state-of-the-art: automated high frequency wheel measuring, enhanced quality of measurements at normal speed (100 km/h) irrespective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Marine Ecosystem Restoration in Changing European Seas' to be submitted under Horizon 2020.

assistant: **Abstract**

The project MERCES is focused on the restoration of different degraded marine habitats, with the aim of: 1) assessing the potential of different technologies and approaches; 2) quantifying the returns in terms of ecosystems services and their socio-economic impacts; 3) defining the legal-policy and governance frameworks needed to optimize the effectiveness of the different restoration approaches. Specific aims include: a) improving existing, and developing new, restoration actions of degraded marine habitats; b) increasing the adaptation of EU degraded marine habitats to global change; c) enhancing marine ecosystem resilience and services; d) conducting cost-benefit analyses for marine restoration measures; e) creating new industrial targets and opportunities.To achieve these objectives MERCES created a multi-disciplinary consortium with skills in marine ecology, restoration, law, policy and governance, socio-economics, knowledge transfer, dissemination and communication. MERCES will start from the inventory of EU degraded marine habitats (WP1), conduct pilot restoration experiments (WP2, WP3, WP4), assess the effects of restoration on ecosystem services (WP5). The legal, policy and governance outputs will make effective the potential of marine restoration (WP6) and one dedicated WP will assess the socio-economic returns of marine ecosystems’ restoration (WP7). The transfer of knowledge and the links with the industrial stakeholders will be the focus of WP8. The results of MERCES will be disseminated to the widest audience (WP9). The project will be managed through a dedicated management office (WP10).MERCES will contribute to the Blue Growth by: i) improving the EU scientific knowledge on marine restoration, ii) contributing to EU Marine Directives; iii) implementing t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'MicroRNA function in cardiac and metabolic disease' (MICARUS), addressing dissemination and exploitation.

assistant: **Impact**

Cardiovascular disease is the primary cause of morbidity and mortality worldwide. Despite numerous treatment options the prevalence of cardiovascular indications continues to increase, underscoring the need for new therapeutic strategies.In recent years, prominent roles of microRNAs (miRNAs) have been uncovered in a variety of cardiovascular disorders. miRNAs are short, single stranded RNAs that regulate gene expression by suppressing multiple, often related, mRNAs.Our studies have focussed on the cardiac specific miRNA, miR-208. We showed that, in the setting of heart failure, genetic deletion as well as therapeutic inhibition of miR-208 resulted in reduced cardiac remodeling (less hypertrophy and fibrosis), the inability to upregulate beta-MHC (a sensitive marker of pathological cardiac stress) and improved survival.Unexpectedly, mice treated with antimiR-208 displayed resistance to obesity and enhanced glucose metabolism in a mouse model of type II diabetes. These effects suggest that the heart plays a previously unrecognized role in systemic metabolic control via a miR-208 dependent mechanism.Although these studies indicate a crucial role for miR-208 in cardiac remodeling and systemic metabolism, the mechanism of action still remains to be defined. Our preliminary gene expression data indicate a cohort of miR-208 targets to be regulated in our stress models, many of which so far have unknown or ill-studied cardiac functions.The aim of the present proposal is to use genetics, gene expression analyses, stress models and antimiR approaches to study the relevance of downstream miR-208 targets for cardiac remodeling and total body metabolism and explore whether additional miRNAs besides miR-208 are relevant for cardiometabolic disease. Together these projects will increa