RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Energy transfer in the photosynthetic bacterial light-harvesting ii complexof rhodopseudomonas acidophila in relation to its 3-d structure and spectroscopy' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Light-harvesting is a key process in photosynthetic conversion of solar energy. Recently the 3-D structure of a bacterial light-harvesting complex has become available. Excitations are transferred within this ring-shaped complex in less then a picosecond, followed by transfer to the next ring, and delivery to a reaction centre. Genetic engineering (with Prof. Hunter in Sheffield, UK) provides control over its functional properties. In this project we relate the energy transfer function of this membrane pigment-protein to its structure and spectroscopy. We will: (1) compare the measured spectral properties with those that can be calculated on the basis of the structure and to obtain estimates for interpigment couplings, energetic disorder and exciton delocalisation, (2) measure the intra-ring energy transfer by the decay of the emission depolarisation, (3) measure the electronic coherence by 2-pulse photon echo and compare the timescale with that of energy transfer, (4) measure the interring transfer by exciton annihilation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Culture of normal human pigment cell progenitors' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

I will establish a culture system to isolate and grow the normal precursors of melanocytes ( pigment cells ) from human foetal skin of different ages, by adaptation of a system for murine melanoblasts recently developed in the host laboratory. I will characterise the markers expressed by the resulting cells by Northern and Western blotting and immunocytochemistry, to determine whether there is one or more than one discrete type of precursor or melanoblast. The effects of individual components and additives in the cultures on the growth and differentiation of these cells will be analysed. These cultures will have many uses related to human pigmentary diseases. A priority will be to examine certain apparently melanoma-specific properties or markers to see whether they are shared with precursor cells. These markers will include the anti-melanoma antibodies of A. Houghton et al., suggested to identify developmentally early and intermediate subsets of melanomas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Personalized Interventions to Improve Intergroup Relations and Promote Peace' under Horizon 2020.

assistant: **Concept**

The recent increase in intergroup hostilities and the intertwining of local and global crises emphasizes the importance of finding ways to attenuate the destructive effects of intergroup conflicts. In recent decades, social psychologists have shown an increasing interest in offering interventions to reduce intergroup prejudice and promote intergroup reconciliation. Yet, in contrast to other scientific fields that strive towards more personalized approaches, most research on intergroup interventions applies the same interventions to all target populations. The proposed project aims to address this gap by introducing an innovative framework for personalized intergroup interventions. The proposed framework is composed of three main layers: a. personalization parameters, b. mechanisms connecting personalization parameters to concrete interventions, and c. the relevant interventions to be tested. The project includes four sequential parts. In part one (WP1) I will conduct six (one for each intervention) meta-analyses in which all available data of studies using these interventions will be gathered and moderations by personalization parameters will be tested. In WP2, online versions of all interventions will be created and tested in two large-scale online studies in two different contexts (Israeli-Palestinian and immigration in Europe) against relevant personalization parameters. Then, in WP3, I will attempt to pinpoint optimal compositions of different interventions, to maximize effects for distinct individuals. Finally, in WP4, I will conduct field interventions in two domains: education and social media, in which screening based on the parameters for personalization is plausible. The project will identify novel mechanisms by which different intergroup interventions differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Hot-spots in biological transformation of silica'.

assistant: **Innovation**

Our scientific concept of the silica cycle is evolving rapidly. New research during the first decennium of this new millennium has clearly shown that silica mobilisation from terrestrial habitats to the aquatic continuum is biologically controlled. Vegetation takes up dissolved silica (DSi) from soil and ground-water and temporally stores it as amorphous Si (ASi) in biomass. This new concept of biological buffering of the silica cycle is essential. The relative newness and novelty of the concept means there are still major gaps in our fundamental understanding, and the integration of processes at different spatial and temporal scales is lacking. Addressing these knowledge gaps is essential. The silica cycle is closely connected to the carbon cycle. Mineral weathering of silicates is an important sink for atmospheric CO2: incomplete knowledge of the bio-Si buffer impedes the accurate quantification of this sink. Moreover, the import of Si into coastal zones from the terrestrial environment is essential to sustain diatom growth. Diatoms play a key role in the oceanic C-sink and in the eutrophication problems in coastal zones. Wetlands provide prime circumstances for biological silica accumulators like grasses, sedges and diatoms to flourish. In this context, tropical rivers attract special attention. They transport huge amounts of suspended material of biological origin into coastal zones. Yet, these areas have received virtually no scientific attention regarding silica biogeochemistry. In this proposal, we aim to conduct studies in two tropical systems, which can be considered hot-spots for biological Si cycling: the Okavango Delta (Kenya) and the Fly River (Papua New Guinea). The overall objective of the proposed research is to increase our understanding of the biologic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regulation and function of IgD in systemic lupus erythematosus' (ACIGDSLE) targeting Seventh Framework.

assistant: **Abstract**

Anti-nuclear antibodies (ANAs) are the most common types of autoantibodies in SLE. Elevated levels of ANAs belonging to the IgD class have long been observed in SLE patients, reflecting dysregulation of the IgD compartment, but the significance of this dysregulation in SLE pathogenesis is completely unknown. IgD in healthy individuals reacts more frequently with nuclear antigens than IgG, the antibody class well-recognized in SLE pathogenesis.The unique properties of IgD, such as the positively charged amino acids in its long hinge region and its high degrees of somatic hypermutation, mayenable IgD to bind many SLE-associated antigens, such as negatively charged double-stranded DNA. These features highlight the strong pathogenicpotential of IgD in SLE. We recently discovered that a discrete subset of B cells undergoes a non-canonical form of IgM-to-IgD class switching upon exposure to a specific cocktail of cytokines, including interleukin-21 (IL-21). We also found that IgD binds to myeloid cells such as basophils, mast cells, monocytes and neutrophils, and induces potent inflammatory responses from these cells, including IL-1 and IL-18 production. The present project aims at elucidating the mechanism of dysregulated IgD production in SLE and the function of IgD in SLE-associated inflammation. We hypothesize that elevated IgD production in SLE originates from a pathological imbalance between IgD-inducing and IgD-restraining signals in B cells, including autoreactive B cells.We contend that such imbalance leads to an increased production of IgD antibodies highly reactive to self-antigens, including autologous double-stranded DNA. We argue that this process enhances inflammation by activating interleukin-1 and interleukin-18-processing signaling platforms in myeloid cells
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Conference on Digital Libraries' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

This conference project aims at providing scientific and organizational support to the European Conference series in research and advanced technology for digital libraries (ECDL) by running the next three ECDL conferences. ECDL was established as an annual European conference three year ago thanks to TMR funding. Since then, three conferences which have been very successful both from the scientific and participation point of view have been organized. Indeed, ECDL is becoming a point of reference for the European DL research community. The main objective of ECDL is to contribute to the creation of a European research community in the new and fast evolving field of digital libraries.To meet this objective, ECDL will: (i) bring together researchers from universities, research centers, industry and government to discuss evolving research issues and applications; (ii) bring together researchers from multiple disciplines whose science relates to the development of digital libraries; (iii) provide an opportunity for these scientists to form a European research community specific to digital library development and enable them to discuss issues and strategies specific to the European context; (iv) assist young researchers in establishing relationships with senior scientists in their areas of interest; (v) enable review, discussion and comparison of research under way in Europe on digital libraries; (vi) stimulate researchers, especially young scientists, to explore new areas of interest in digital library development; (vii) establish a forum for discussion of issues specific to Europe such as interoperability, multilinguality and intellectual property policy and information commerce. ECDL, during its short life, has featured and will further stress two main aspects of the DL fie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An innovative process for the regeneration of acids used in the steel pickling process' (REGMAX).

assistant: **Innovation**

Pickling is a metal surface treatment used in the stainless steel industry to remove impurities from steel and obtain optimal services. Every hour, approximately 270,000 litres of acid are used in pickling, resulting in huge quantities of waste acid. Alongside the damaging environmental impact, steel pickling works suffer from high operational costs to manage the disposal or regeneration of said acid. SUSTEC has developed the REGMAX system, a new acid regeneration process to provide a sustainable low-cost solution to this problem. The REGMAX system increases acid regeneration rate to over 97% and reduces operational costs by up to 91%. Within the overall project, SUSTEC intends to finalise plant engineering and scale-up regeneration capacity; and commission a pilot plant for a large scale demonstration and validation of the technology in industrial conditions.


**Keywords:** acid regeneration, waste acid, sustainable steel production, steel pickling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'IN-Silico trials for treatment of acute Ischemic STroke' (INSIST).

assistant: **Concept**

Stroke is the number one cause of disability in the Western world and the 3rd most common cause of death. Despite new treatment options with intra-arterial thrombectomy, still 2 out of 3 patients still have a poor outcome. The main goal of INSIST is to advance treatments of ischemic stroke and its introduction in clinical practice by realizing in silico clinical stroke trials in which stroke and treatment are modeled. We will generate virtual populations of stroke patients, generate and validate in silico models for intra-arterial thrombectomy, thrombosis and thrombolysis, and microvascular perfusion and neurological deterioration after stroke, and integrate the in silico models to realize an in silico clinical stroke trial. We are uniquely positioned by the availability of a large pool of clinical, imaging, histopathological, and outcome data from multiple recently finalized stroke trials, a large registry (totaling 4500 patients), and new trials that will start later this year (totaling 2500 patients). We will build a population model that takes this input to generate virtual populations of stroke patients addressing the wide variety of patient characteristics. We will build on existing and emerging in silico models to validate reusable models for stroke and stroke treatment with a strong interaction with experimenting modeling in laboratories. The in silico models and virtual populations will be combined to simulate clinical trials and validated by simulating and comparing finalized and currently running trials. The in silico models will be used to simulate clinical trials to evaluate effectiveness and safety of novel devices and medication, both for the device as well as the pharmacological industry. For the device industry, we will evaluate the optimal configuratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Nanomaterial Photonic Sensors for Food Manufacturing' (NPS4FM) targeting Seventh Framework.

assistant: **Abstract**

The ultimate goal of the project is to generate and transfer knowledge on the development of new nanomaterials specifically applicable in novel macro-bacterial sensors for food manufacturing and processing industry.The special structure of nanomaterials gives rise to their amazing properties. The ability to manipulate the structure and composition on the nanoscale provides very large opportunities to create new materials with superior performance for new products and devices. Since the optical properties of nanomaterials can be controlled by changing their size, shape, and aspect ratio, as well as via their surface modification, nanomaterials are prime candidates as building blocks for photonic sensors.The overall objective of this research is to develop the synthesis of ZnO, ZnS and PbS nanostructures with different sizes and morphologies via the laser ablation in liquid technique, then to modify and functionalize the surfaces of the prepared nanostructures and finally to use them for the preparation of photonic sensors with bacteria-detecting properties. Such efficient, easy-to-use and rapid sensors will be evaluated within different food processing, weighing and packaging lines available from project partner.This is an ambitious research programme, with a strong interdisciplinary nature combining materials engineering, surface science, bio-engineering, physics, chemistry and soft matter science. Its success is underpinned by the combination of complementary expertise of the Fellow, Host and Partners in nanomaterial preparation and characterization, photonics and food processing and analysis, respectively.  The project will have a positive impact on a longer shelf-life of ready food, monitoring of food manufacturing lines, and optimization of cleaning routine during f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Harvesting solar energy with multifunctional glass-polymer windows' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In HarWin new materials will be developed with the aim of constructing next generation windows. These windows will improve significantly energy efficiency of windows and the buildings. They will enable extension of window functionality beyond the current European State of Art. The improvements are based on reduced weight, reduced thermal conductivity and energy consumption, reduced material usage and life cycle environmentalperformances control of the windows. New additional functionality, like e.g., window integrated functional coatings will be combined with intelligent phase changing materials and novel glass-polymer composites with wavelength management capability. The new materials will combine heat and moisture control by means of new laminate and fiber reinforced structures for glasing and integrated light weight framing of windows. On long term, the windows developed within HarWin will enable creation of a new type of buildings, where merging of functionalities currently assigned separately to windows and architectural glass will result in a new definition of multifunctional façade, adjustable according to geographic and cultural needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chromatin dynamics during X-inactivation: assessing the role of different chromatin changes in the loss of gene activity and the gain of gene silencing', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

X-inactivation (XCI) is an epigenetic phenomenon resulting in transcriptional silencing to attain gene dosage parity between XX females and XY males. XCI involves coating of the non-coding Xist RNA followed by depletion of euchromatic marks and shortly after accumulation of heterochromatic marks. The chromatin modifying activities that are involved in these steps and their functional interplay remain poorly understood however. We will specifically assess how euchromatic marks, such as H3K4 methylation and H3 and H4 acetylation, are lost shortly after Xist RNA coating and the importance of this loss in gene silencing and heterochromatin formation. First, we will perform functional studies in differentiating XX ES cells, including knockdown of chromatin modifying candidates, such as H3K4 demethylases and histone deacetylases. Second, we will investigate how specific X-linked loci behave during XCI, using a Lac or Tet operator tagging system. This will allow us to (a) visualise a locus in living cells and assess the exact timing of recruitment of proteins of interest (fused to a fluorescent protein), in control and knockdown situations; and (b) target specific chromatin factors (using the Lac or Tet repressor fusion) to a locus in order to assess the impact of chromatin changes on XCI. In summary, the two complementary strategies outlined here should provide us with new insights into the roles that various chromatin changes associated with XCI actually play in this process. This should also give new insights into the process of gene regulation in other systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International consortum on ticks and tick-borne diseases (concerted action on the control of tick-borne diseases of ruminants in developing countries)' (1998-2002) under Fifth Framework.

assistant: **Objectives**

A number of European, African and Latin American institutions working on ticks and tick-borne diseases (TBD) of ruminants proposes to expand their research efforts by creating a unique international consortium. They will develop an online database for hem parasites to facilitate vaccine development and improved diagnostics. Virtual tick museum will be created linking up available tick collections and used to design taxonomic keys and predictive maps for ticks infesting ruminants in the target areas. Available serological tests will be adapted to a rapid dipstick format and, together with southern blots, evaluated for collection of improved data in epidemiological studies. Four seminars will be organised; on hemparasitegenome analysis, molecular studies, chemical tick control and integrated Control strategies. All information will be published in Newsletters, CD-ROM and journals.