RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identifying key neuronal pathways mediating melanocortin's effects on cardiovascular function' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Population statistics demonstrate drastically increased risk of cardiovascular death with increasing body mass index. Given the current obesity epidemic our need to understand the central neuronal pathways regulating energy homeostasis and cardiovascular function could not be greater.This proposal aims to determine key neuronal pathways mediating melanocortin's autonomic effects on cardiovascular function. It combines molecular genetics and whole animal physiology to advance translational research in the development of effective therapies against obesity-induced hypertension. Recent evidence suggests that both obesity and essential hypertension are associated with increased sympathetic nerve activity. Increased sympatho-activation in obesity-associated hypertension has been linked to increases in central signalling via the melanocortin-4-receptor (MC4R).We hypothesize that the pressor actions of obesity are mediated via specific MC4Rs on central neurons regulating arterial blood pressure. We will investigate which subpopulation of MC4Rs mediates melanocortin's effects on cardiovascular function using functional genomics approaches, including an MC4R deficient mouse, in which a disrupted MC4R can be reactivated in specific CNS areas by the actions of Cre-recombinase. Using in vivo mouse telemetry we will thus determine the neuronal pathways involved in melanocortin-mediated regulation of cardiovascular function and define the MC4R¿s role in obesity-induced activation of the sympathetic nervous system.This proposal is absolutely consistent with the Sixth (and future 7th) Framework Programme, placing particular emphasis on functional genomics and the combat against major diseases such as hypertension. Furthermore, it brings significant skills in state-of-the-art generation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Info day portugal, the candidate countries and era""' in the context of a Fifth Framework call.

assistant: **Objectives**

Portugal the Candidate Countries and Erin view of the participation of Candidate Countries in the Framework Programmes of the EC, the Institute for International Scientific and Technological Research (ICCTI), of the Ministry of Science and Technology in Portugal, would like to promote an Information Day with some CC's, namely, Hungary, Poland, the Check Republic and Romania, in order to develop and reinforce cooperation links between researchers from these countries. The event is intended to focus on the following areas of research: Biotechnology applied to Health Sciences and Food Safety and Materials and Nan technologies, and would be held in two days. It would include presentations from EC officers, researchers from CEEC that are working in Portuguese Universities and Portuguese and CC's presentations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chasing a Fundamental Challenge in Catalysis: A Combined Cleavage of Carbon-Carbon Bonds and Carbon Dioxide for Preparing Functionalized Molecules', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

FunCBonds offers a novel perspective to relevant scientific synthetic problems via a synergistic dual catalytic activation of carbon-carbon bonds and CO2, a topic of major interest not only for basic research science but also from an industrial and social point of view. As the use of alternative feedstocks such as CO2 is still one of the most fundamental gaps in catalytic technologies, I believe that FunCBonds project provides an alternative vision and strategy for the preparation of pharmaceutically relevant carboxylic acid derivatives using inexpensive raw materials in a catalytic fashion. In contrast to the well-established methodology based on carbon-carbon bond formation using either ruthenium or palladium catalysts (recently awarded with the Nobel Prize in Chemistry 2005 and 2010, respectively), the main challenge of this project is the discovery of a non-expensive and non-toxic catalyst that allows the cleavage of C-C bonds and CO2 following the principles of the atom economy. FunCBonds will meet these challenges by offering an innovative approach that will unlock the potential of a combined functionalization of inert C-C and C-O bonds. The project will provide the necessary understanding behind the factors influencing both C-C bond cleavage and the subsequent CO2 insertion event, thus opening up new horizons in preparative organic chemistry as well as offering solutions to a social and industrial problem such as the use of CO2 as chemical feedstock.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accretion and Differentiation of Terrestrial Planets' (EARLYEARTH) under Seventh Framework.

assistant: **Objectives**

This proposal aims to constrain the late accretion history of the Earth and the differentiation of the earliest silicate reservoirs in planets. Highly siderophile elements (HSE) constrain the late accretion of material onto the Earth; a process that potentially delivered water to Earth. During core formation, HSE strongly partition into metal. Once core formation ceases, newly accreted HSE-rich material will significantly contribute to the HSE budget of the Earth’s mantle. The HSE are more abundant in the Earth’s mantle than predicted from low temperature partitioning experiments and feature nearly chondritic relative abundances. This implies a significant late accretion of chondritic material (“the late veneer”). This idea is challenged by high pressure/temperature experiments indicating that the HSE were left in the behind in the mantle during core formation, thereby calling into question the late veneer. To address this issue, I propose the setup of new isotopic tracers and utilize (i) nucleosynthetic anomalies and (ii) stable isotope systematics of the HSE to determine the origin of HSE in the Earth’s mantle. Unravelling this issue is a major advance in understanding planetary accretion. Formation of the earliest silicate reservoirs probably occurred contemporary to late accretion. Global differentiation in terrestrial silicate reservoirs may have taken place within the first 30 million years of the Earth’s formation based on Sm-Nd isotope data. This timing has been debated on various grounds. The 92Nb-92Zr decay system is a potentially powerful chronometer to further constrain this issue. Its usefulness, however, has been hindered by uncertainties of the initial 92Nb abundance in the solar system. I propose to obtain unequivocal evidence from old differentiated met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of automated technology for large scale land based production of lobster juveniles and lobster to market size, including development of robotic feeding and imaging control system', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Strategic Objectives Addressed:  The proposed project is focused on making large scale land based farming of European and American lobster feasible, both financially and practically, by developing automated technology for feeding and monitoring of each lobster individually. European and American lobster are cannibalistic in nature, and are therefore kept in individual housing cells demanding individual handling, which without automated technology has proven to be too labour consuming. The LobsterPlant project will by making large scale farming of lobster a reality, contribute to filling the gap between market demand and market supply of lobster and reduce the need to harvest natural lobster, whose population is already low due to over harvesting. There is currently no competing technology on the market which makes large scale farming of lobster feasible, so the proposing partners are hence creating a new market for themselves.    Abstract:  The demand for European lobster exceeds supply. Current European lobster landings can only supply 2–7% of the market demand as the natural stock is simply insufficient to sustain an annual harvest required by the market due to over fishing which has depleted stocks. Large scale aquaculture of lobster is an alternative method to provide the supply to the market, but has not to date been feasible due to lack of automated technology available. The LobsterPlant project will make large scale farming of lobster possible by developing of:  • automated feeding and imaging technology for feeding and monitoring of the lobsters • cleaning technology for removal of waste in raceways  • feed of right stability for the automated feeding technology and • determine optimal methods for control of water quality in lobster plants
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Past atmospheric circulation and glaciation during the Egesen Stadial in the Swiss Alps'.

assistant: **Objectives**

The general pattern of Late Glacial glacier advances is relatively well established at a few type sites in the European Alps. Most research has focused on the Egesen Stadial (ES), equated with the Younger Dryas (c. 12.9 to 11.5 ka BP) as identified from Greenland ice cores. In the Swiss Alps, however, only patchy evidence and few dated ES sites exist, and there is virtually no information on glacier coverage and dynamics; palaeoclimatic or past atmospheric circulation patterns are not known. The latter are known to have differed from those today during the Last Glacial Maximum.   This project addresses important knowledge gaps in that it proposes to:  (1) map the geomorphological and geological evidence of Egesen and other Late Glacial stadials along a N-S and E-W transect through the Swiss Alps,  (2) reconstruct palaeo-glacier dynamics, ice mass extent and palaeoglaciological variables such as the thermal regime of ES palaeo-glaciers using sedimentological field and laboratory analyses and  (3) reconstruct equilibrium line altitudes and from them quantify palaeo-precipitation.   A rigorous dating programme consisting of optically-stimulated luminescence, cosmogenic radio-nuclide and radiocarbon dating will be applied to reliably determine the location of the Egesen moraines throughout the Swiss Alps. Cross-correlation between these methods is likely to yield very accurate and reliable ages. The distribution of ES glaciers will also be used to reconstruct atmospheric circulation patterns.   Quantified palaeoclimatic data, which form the main output of this project, are urgently needed to constrain numerical models used to predict future climate change. In addition to their scientific importance for understanding the climate-glacier interactions at the Pleistocene-Holoce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Consequences of Mismeasuring Economic Activity' (MEImpact) targeting Horizon 2020.

assistant: **Abstract**

Measuring economic activity is a fundamental challenge for empirical work in economics. Most empirical projects raise concerns about whether the data do in fact measure what they purport to measure. Mismeasurement may lead to severe model misspecification, biased estimates, and misled conclusions and policy decisions. Unfortunately, formally accounting for the possibility of mismeasurement in the econometric model is complicated and possible only under strong assumptions that limit the credibility of resulting conclusions. Therefore, the most common approaches to measurement issues are to ignore them, to informally argue why they may not be of first-order importance, to abandon the project, or to search for better data.The objective of the research described in this proposal is to develop new methodologies for formally assessing the potential impact of measurement error (ME) on all aspects of an empirical project: on model-building, on estimation and inference, and on decision-making. For instance, the new inference procedures allow the researcher to test whether ME is a statistically significant feature that should be modeled, whether ME distorts objects of interest (e.g. a production or utility function), whether ME distorts conclusions from hypothesis tests, and whether ME affects subsequent decision-making. I show that answering such questions is possible under much weaker assumptions than identification and estimation of a ME model and thus leads to more credible and robust conclusions. In addition, the implementation of the new procedures can be based on standard nonparametric estimation techniques that are part of many applied researchers’ toolkits.In consequence, the research has the potential to fundamentally transform the way empirical researchers approach mea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MAchine for Time Reversal and Immersive wave eXperimentation' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is a need for a radically new laboratory experimental approach for studying the interaction of seismic waves with the complex media of the Earth’s subsurface. We present here a fundamental new approach to seismic wave experimentation that involves fully immersing a physical seismic experiment within a virtual numerical environment. This enormously challenging endeavour, which is relevant to many outstanding issues in seismology, has not been previously attempted. By continuously varying the output of numerous transponders closely spaced around the physical domain using a control algorithm that takes advantage of measurements made by a scanning Laser-Doppler Vibrometer and a novel theory of exact boundary conditions, waves travelling between the physical and numerical domains will seamlessly propagate back and forth between the two domains without being affected by reflections at the boundaries between the two domains. This will allow us to investigate diverse types of Earth materials using frequencies that are much closer to those of seismic waves propagating through the Earth than previously possible.The novel laboratory enables experimentation under highly controlled conditions. A broad range of long-standing problems in wave propagation and imaging that have eluded Earth scientists and physicists for decades will be addressed. Fine scale heterogeneity, porosity and fluid saturation in real Earth media result in complex frequency-dependent amplitude and phase responses that we can characterize in the laboratory. Synthetically produced complex models can be used in wavefield-focussing experiments and to achieve complete elastic time-reversal for the first time ever. We will study coda waves that can be indicative of slight changes in stress fields before catastro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Perfume allergy - an increasing problem.Identification of risk factors and their control' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

- To identify the major fragrance ingredients causing allergic contact dermatitis. - To determine threshold concentrations for elicitation of contact dermatitis in fragrance sensitised individuals depending upon skin region and product type. - To investigate the relationship between exposure concentration and exposure time for elicitation of contact dermatitis in fragrance sensitised individuals.- To determine actual exposure concentration to selected fragrance materials in deodorants.Sensitivity to fragrance ingredients is a common problem. It has been demonstrated that 8-15% of individuals with eczema and 1-2% of the general population are allergic (delayed hypersensitivity) to fragrance ingredients. Sensitivity to these ingredients can cause an inflammatory skin reaction (allergic contact dermatitis), which is costly to medical services and results in social and occupational handicap. A series of clinical studies will be carried out in a multinational, five centre project. A rank order of the major fragrance ingredients causing problems will be made by determining the frequency of reactivity to a series of known sensitising fragrance materials in eczema patients. Further more a cohort of individuals who are allergic to fragrance compounds will be identified and the allergic component(s) in these products will be ascertained by fractionation and subject challenge. An assessment of exposure of these sensitising component(s) in consumer products will then be made by chemical analysis. Factors causing the production of clinically evident skin disease (concentration, skin site, exposure time) will be evaluated. The identification of the fragrance chemicals responsible for the induction of hypersensitivity in the community will provide data for the regulation of fragrance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'COFUND BIST PREDOCTORAL PROGRAMME' under Horizon 2020.

assistant: **Concept**

The PREBIST proposal is presented by the Barcelona Institute of Science and Technology (BIST) as beneficiary. PREBIST is an ambitious programme of 28 four-year fellowships for multidisciplinary pre-doctoral research at BIST´s constituent research centres and associated partner institutions (hospitals, private companies, technology centres, and other academic institutions), who will provide secondments, training, networking activities and other actions to complement the research activities and professional development of the fellows. The PREBIST proposal is a major initiative by which BIST aims to leverage the combined capacities of the constituent centres in a manner which none of them could do on their own and help achieve the strategic objectives of BIST. Key objectives of PREBIST are to:• Boost the capacity for international talent attraction with increased visibility, strengthened recruitment processes, improved offerings of research areas with interdisciplinary and intersectorial aspects, and improved landing-pad processes to facilitate mobility;• Improve BIST centre capacities in the management of researcher career development, scientific and technical training, and new offerings in complimentary skills training and outreach activities;• Further drive interdisciplinary and intersectorial collaboration between BIST centres and other partner entities through joint research activities, secondments and technical trainings, improved access and utilisation of infrastructures, networking and development of personal contacts, joint seminars and workshops.


**Keywords:** DOCTORAL TRAINING, BIOMEDICINE, NANOTECHNOLOGY, NANOSCIENCE, PHYSICS, ASTROPHYSICS, CHEMISTRY