RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Study of phenol-like compound, a newly discovered class of plant specialized metabolites.' (CHORPATH), addressing dissemination and exploitation.

assistant: **Impact**

Plants produce arrays of specialized metabolites that are crucial for plant development, defense and interactions with the ever-changing environment. Discovery of metabolites and metabolic pathways by dissecting the underlying genetic basis is an important challenge, not only to increase our understanding of life, but also to provide indispensable applications for humans such as pharmaceuticals. In this project we will investigate the occurrence and biosynthesis of the phenol-like compound, a novel metabolic class that was recently discovered by the host group in the plant model Arabidopsis (unpublished). Notably, chemically synthesized phenol-like compound and analogues have been shown to be potent in vitro inhibitors of chorismate-utilizing enzymes. This inhibitory activity hints to a potential biological role for phenol-like compound in regulating the flux through these pathways, opening perspectives for applications. The direct objective of my project is to unravel the biosynthetic pathway of phenol-like compound. We therefore aim i) to structurally identify additional pathway intermediates and sinks via LC-MS based metabolite profiling and purification followed by NMR, ii) to test whether chorismate is a precursor of the pathway by feeding plants with Stable Isotope Labeled chorismate, followed by analyzing the MS fragmentation spectra of the labeled molecules, iii) to investigate the role of an operon-like gene cluster involved in the biosynthesis of phenol-like compound via reversed genetics, and iv) to obtain insight in the in planta role of phenol-like compound by feeding experiment followed by metabolic profiling. My experience in reversed genetics and enzyme kinetics in specialized metabolism in rice make me well suited to bring this project to success. My pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Applications of operads to homotopy theory and homological algebra' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content This project is concerned with the following applications of operads: The unstable Adams spectral sequence is the main tool for calculating the homotopy type of a topological space. One version of this spectral sequence is based on a model of the loop space construction. Another spectral sequence in homotopy theory based on the loop space construction is Barratt's desuspension spectral sequence. I propose myself to improve these calculational tools by generalizing the construction of these spectral sequences to iterated loop spaces. The little $r$-cubes operad encodes the structure of an $r$-fold loop space and provides an efficient model for this generalization. Operads theory furnishes a nice homology theory for Poisson algebras. I expect to show that this homology theory determines the cyclic homology of some filtered algebras, generalizing to the non smooth case a method due to Brylinsky. Training content (objective, benefit and expected impact) I need knowledge in combinatorial homotopy theory which I may learn from Professor Baues. Moreover, fruitful applications of operads in low dimensional topology, and geometrical physics have been found recently. At the Max Planck Institut, I could establish fruitful international contacts with mathematicians working on these aspects of operads theory. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dark Matter and Effective Field Theories' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The question about the nature of dark matter is central in modern physics. Recently, increasing attention has been paid to the possibility of a dark matter with mass between the keV and the GeV, whose search requires novel detection techniques, and signatures involving low energy collective excitations. I propose to apply the recently developed effective field theories for condensed matter to study the interaction between light dark matter and the collective excitations of the detector. In particular, I propose to investigate possible two-dimensional detectors via two new signatures: the excitation of out-of-plane phonons and of electron density waves due to the interaction with dark matter. The effective field theory approach to condensed matter has the advantage of being independent on the complicated details of the microscopic physics, and of being formulated in a quantum field theory language, a framework very familiar to particle physicists. For these reasons, the present proposals has the potential of addressing a key question in modern physics, while bridging the gap between the high energy nature of the question about dark matter and the condensed matter issues related to its detectability. If accepted, the program will be carried out at New York University (NYU) for the first two years, and at Sapienza University of Rome for the third one. These institutions are perfectly complementary for what concerns the successful implementation of the program. NYU hosts world leading experts in dark matter model building and phenomenology, while Sapienza hosts a research program in the design and realization of detectors for light dark matter that is at the forefront the international research on the topic. The interaction with the two research groups will allow me to deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Safety and efficacy of Dolutegravir and EFV400 for pregnant and breastfeeding women -  a randomized non-inferiority clinical trial' (PREGART) under Horizon Europe.

assistant: **Objectives**

PREGART is a multi-national Phase-4 randomized clinical trial aimed at identifying optimal antiretroviral treatment (ART) regimens by comparing the efficacy and safety of dolutegravir- versus low-dose efavirenz (EFV400mg-) based first-line cART regimens in 1156 HIV-infected pregnant women and infant pairs in Ethiopia and Uganda. The primary outcomes are undetectable viral load at delivery, prevention of mother-to-child transmission of HIV, and adverse pregnancy outcomes. The COVID-19 pandemic significantly hampered all trial activities, including patient enrollment, follow-up, regulatory approvals, and trial site initiation. All clinical trial activities were suspended to protect the safety of study participants (pregnant women and infants) following the stay-at-home orders during the initial wave (March - September 2020) and intermittently during the subsequent waves of COVID-19. Furthermore, the PREGART trial activity was affected by the civil war in northern Ethiopia (2021/22) and the Ebola disease outbreak in Uganda (2022/23). Efforts have been made to mitigate these challenges by opening new trial sites, adapting protocols, and utilizing decentralized trial approaches to increase the participant recruitment rate. To complete the PREGART clinical trial, we request another 36 months and 1.8 million euros to compensate for time and incurred financial loss due to the COVID-19 pandemic, the civil war in Ethiopia, and the Ebola outbreak in Uganda. Completion of clinical trial activities and data analysis will fulfill our obligation to protect the scientific quality and data integrity, ensuring our commitments to study participants and meet PREGART trial objectives - to provide comprehensive and statistically powered evidence for policymakers on the maternal and infant sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Land-surface processes and climate response.', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

To increase our understanding of the role that land-surface processes play in climate change predictions and determine our ability to model the interactions between the land-surface and the atmosphere in a changed climate. The objectives will be achieved by conducting two types of experiments. Firstly, a series of time-slice  experiments in a greenhouse-gas warmed climate with each of the five European General Circulation Models  (GCMs) using different land-surface schemes. Secondly, a number of simulations with GCMs and regional  models to assess the climatic impact of deforestation which has occurred in the Mediterranean region.  Analysis of the different time-slices for each of the GCMs will reveal the sensitivity of the climate response to  land-surface processes. This will determine which aspects of climate change are affected by the way the surface  is modelled. Comparing this result with the difference in sensitivity of the five GCMs to an increased CO2  concentration will reveal the importance of the uncertainty in land-surface modelling relative to other processes  being modelled in the GCMs. This analysis will focus on the hydrological cycle and surface conditions in a CO2  enhanced climate.  The influence on impact studies due to the uncertainty in climate change simulations will be studied in the  special case of vegetation. The results from the time-slice experiments will be used to compute potential  vegetation maps.  The second set of experiments will compare the climatic impact of a similar change in land-surface conditions  as simulated by different global models. The corresponding simulations with regional models will allow us to  study the importance of finer resolutions on the simulation of surface processes. The impact of small scale  features on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Commercialisation of neuronal cell co-cultures' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Development of various human stem cell derived cell types will be carried out to see the completion of the FETOPEN MESO-BRAIN project. Based on immortal pluripotent stem cells (iPSCs), FETOPEN MESO-BRAIN will see the development of techniques for growth of a variety of neural cell types. This provides a unique opportunity for the creation of a marketable product stemming from already intended work. Co-cultured in vitro cell models have the capacity to retain neuronal maturity and functionality for long time periods. Such co-cultures, featuring only two or three different cell types have already been demonstrated as effective models for researching the mechanisms of conditions such as Alzheimer’s disease, indicating consistent and reproducible results. As such, complex and consistently reproducible ready-made co-cultures could be easily directed towards pharmaceutical and biotech companies seeking to use iPSC-derived cells as a basis for building cell-based assays and drug screening based on the validated cells.As the FETOPEN MESO-BRAIN project already intends to grow major neuronal cell types, complex, physiologically relevant 2D and 3D co-cultures featuring cortical neurones, astrocytes, interneurons and microglia can be developed within COMMER-CELL and made available for sale. Creation and mass-availability of a 4-cell-type co-culture in an easy-to-use and premade form could not only allow for improved research into CNS-affecting conditions and drug testing, but also expedite such research by circumventing the need for research institutions and industrial organisation to create their own time-consuming cell models.  The proposed COMMER-CELL project harnesses results from MESO-BRAIN to deliver concrete added value by raising the technological maturity of the cells to d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Surveillance Network for Influenza in Pigs 3' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This “European surveillance network for influenza in pigs (ESNIP) 3” will maintain and expand surveillance networks established during previous EC concerted actions (ESNIP 1, QLK2-CT-2000-01636; ESNIP 2, SSPE-022749). Three work packages (WP 2, 3, 4) aim to increase the knowledge of the epidemiology and evolution of swine influenza (SI) virus (SIV) in European pigs through organised field surveillance programmes (WP2).  Virus strains detected in these programmes will be subjected to detailed characterisation both antigenically (WP3) and genetically (WP4) using standardised methodology. Specifically this will involve timely information on genomic data and generation of antigenic maps using the latest technology. These analyses will provide significant and timely added value to knowledge of SIV. A strong focus will be monitoring spread and independent evolution of pandemic H1N1 2009 virus in pigs. All these data will in turn be used to improve the diagnosis of SI by updating the reagents used in the recommended techniques (WP2). The virus bank and electronic database that were established during ESNIPs 1 and 2 will also be expanded and formally curated with relevant SIV isolates and information for global dissemination within and outwith the consortium (WP5). ESNIP 3 represents the only organised surveillance network for influenza in pigs and seeks to strengthen formal interactions with human and avian surveillance networks previously established in ESNIP 2. A timely and transparent interaction with these networks will be a key output. These approaches are entirely consistent with improved pandemic preparedness and planning for human influenza whilst providing an evidence base for decisions in relation to veterinary health.  The project consortium consists of 24 participa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Targeting the vascular-immune interface to induce anti-tumor immunity'.

assistant: **Concept**

In this ERC Synergy Grant, we will characterize the vascular-immune interface in melanoma and glioblastoma and explore the perivascular niche as a site for local anti-tumor immune activation.Cancer immunotherapy has made tremendous progress in the last two decades, but a vast majority of cancer patients do not benefit from this progress yet. Refinement of established immunotherapies will undoubtedly increase response rates. However, conceptually brave new therapies must be developed to make additional breakthroughs. The tumor vasculature plays a key role in orchestrating anti-tumor immunity by regulating recruitment and activation of T-cell and other immune cells. We propose to make a detailed characterization of vascular immune landscapes in melanoma and glioblastoma and to utilize this to optimize vascular-immune crosstalk and immune response as a new breakthrough immunotherapy.This proposal builds upon new knowledge on how immune hubs can form around tumor vasculature, which to a large part is based upon novel findings and development by the applicants (1, 2) on the importance of perivascular antigen-presenting niches in activating, sustaining, and executing CD8 and CD4 T-cell-mediated immune attacks on cancer. We will develop tumor vessel targeting AAV vectors that can enable therapeutic induction of immune hubs in cancer. This new form of immunotherapy will be evaluated alone and in combination with established cancer immunotherapies.Combined, our research teams are in a unique position to achieve this goal. Synergistic advancements will be obtained by joining Dimberg’s expertise in the vascular and immune microenvironment in tumors (especially glioblastoma); Tüting’s expertise in tumor immunology and cell plasticity (especially melanoma); and Essand’s expertise in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'microRNAs in susceptibility to traumatic stress' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Ergodic theory for complex systems: a rigorous study of dynamics on heterogeneous networks' in the context of a Horizon 2020 call.

assistant: **Objectives**

Nowadays, networks of interacting systems appear in many areas of Science such as physics, chemistry, biology and also engineering and the human sciences. Examples range from solid state physics, to astrophysics, reaction-diffusion equations, transportation systems, the Internet, social networks, opinion models, etc. This vast spectrum of applications has stimulated a broad interdisciplinary endeavour to predict and control the behaviour of so-called ""complex systems"", namely large ensembles of units coupled through an intricate interaction web. While various theoretical and computational approaches to these systems have been developed, from the mathematical perspective, their analysis remains extremely challenging. Very little has been accomplished, especially as the description of the dynamical mechanisms underlying overall functioning is concerned.  The proposed project aims to develop a novel rigorous approach to describe the emergence of global behaviour in complex heterogeneous systems, given their microscopic constituents such as individual dynamics and interaction nature/structure. At the interface between pure and applied mathematics, our approach will rely on results from abstract ergodic theory, especially as they have been recently obtained for non-uniformly hyperbolic systems, to address concrete mathematical models exhibiting real-world features.""


**Keywords:** Ergodic Theory, Dynamical Systems Coupled on Networks