RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Defining the functions of novel integral membrane regulator, CMTM family in B cell development and acute lymphoblastic leukemia'.

assistant: **Innovation**

Despite the vast improvements in survival, acute lymphoblastic leukaemia (ALL) remains one of the major causes of death in children. The current combination chemotherapy causes acute and long-term toxicity. Hence, there is a compelling need to understand the development of ALL and identify key players that could be used in targeted therapy. The B cell receptor (BCR) and its precursor, pre-BCR, control the regulation of B cell differentiation and therefore aberrant pre-BCR and BCR functions results in B cell leukemia. The aim of my project is to identify new membrane associated drug targets for BCR-ALL therapy through investigating the functions of recently discovered Chemokine factor like Marvel like Trans Membrane proteins (CMTM) that interacts with the BCR and the intracellular adaptor, SLP-65, in B cell developmental process. To achieve this, I will employ multidisciplinary approaches and focus on the first B cell developmental checkpoint, the pre-BCR stage. The main objectives of the project are (i) to discover and characterize the CMTM mediated macro molecular assemblage using systems biology approach (ii) to identify the CMTM mediated downstream signaling network emanating from the pre BCR through cell biology and next generation sequencing methodologies and (iii) to determine the structures of pre BCR membrane/cytosolic multi protein CMTM mediated complexes using NMR or X-ray crystallography. Thus, the proposed project will discover the role of new membrane regulators in pre B cell development and pre BCR-ALL. I propose to set this previously not existing B cell membrane regulator research theme at Newcastle University, U.K. moving from my previous position at the George Washington University, USA. This program will open new avenues for B cell lineage ALL treatme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of non-antibiotic therapy for the treatment of bovine mastitis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Bovine Mastitis is a bacterial infection of the cow udder. It is the major problem in the dairy sector, causing losses of approximately €1.5Bn in Europe each year, with each case costing the farmer €285/case. Current treatments use conventional antibiotics. These solutions are not ideal: - they are not always effective- bacteria can gain resistance to the antibiotics- for a period of time during and following treatment (the 'withdrawal period' which can be up to 9.5 days) the milk must be discarded to prevent entry of antibiotic residues into the human food chainAdditionally there is a growing pressure for the need for new antibacterial approaches in animal health to lessen the pressures on existing antibiotics for human usage.PanaMast is a novel innovative non-antibiotic antimicrobial technology.We are seeking to develop a novel mastitis treatment based on this technology. It is effective against all bacteria tested in the lab, including antibiotic-resistant strains, such as MRSA. Additionally, bacteria have been unable to gain a resistance to PanaMast. PanaMast is composed of natural products, which have a proven safety and toxicity profile. As such, this non-antibiotic approach aims to be the Worlds first Zero-withdrawal product, allowing farmers to sell milk both during and following treatment, while delivering an effective treatment regimen. In preliminary field trials against mastitis caused by Staph. aureus, we have shown a 70% cure rate, compared to a 5-15% cure rate using conventional treatments. This has a range of advantages over current products, namely: - effective against all bacteria- ability to treat antibiotic-resistant bacteria- no resistance to the product- zero withdrawal periodPanaMast therefore has the potential to dramatically improve the way mast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Process reengineering in concurrent engineering/call on SMES teams' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

PRICE/COST: Process Reengineering In Concurrent Engineering/Call On Smes Teams will constitute an SMEs contribution to the Aeronautical Concurrent Engineering endeavour submitted to the Aeronautical Task Force. The main goal of PRICE/COST will be to set up at least four European local Aeronautical Subcontractors << user groups >> SMEs and to establish a link with major Aircraft Manufacturers in order to capture capabilities and needs in Process Reengineering from Large Companies and SMEs. Price/Cost will focuse on the research of an efficient group of Best Practice to disseminate into the large aeronautical supply chain as a whole. Owing to the fact that product selling PRICE is controlled by market laws, SMEs will concentrate their effort on COST, in order to maximise the PRICE/COST ratio.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Joint Operation for Ultra Low Emission Shipping' (JOULES) under Seventh Framework.

assistant: **Objectives**

Reducing emissions from shipping has increasingly become a challenge over the last years, both as a counter measure against global climate change and to protect local environments and population from waste, gas emissions and noise.This challenge has been documented both in policy papers, like the Europe 2020 initiative or the Transport White Paper, and in rules and regulations issued by IMO as well as by local authorities. Those legislations as well as emission taxes and an increasing public awareness on green shipping have led to the fact, that low emission ships and shipping has become a key competitive factor both for European shipbuilders (including equipment manufacturers and shipyards) and shipping companies.In response to topic SST.2013.1-2 of the Sustainable Transport Work Programme 2013 the JOULES proposal aims to significantly reduce the gas emissions of European built ships, including CO2, SOx, NOx and particulate matters.JOULES follows an integrated and holistic approach, not only limited to integrating the components of the simulation of the energy grid, but through the consideration of other viable options for emission reduction.The specific optimal solutions for emission reduction and energy efficiency highly depend on the transport or service task of ships, as well as on their operational profile. While a wide overview and holistic assessment of all available energy and emission saving technologies is necessary, industrial breakthrough can only be achieved if the available solutions are selected, adopted, integrated, assessed and finally demonstrated for realistic application cases. The binding element between technologies and applications are modelling and assessment methods and tools. Those are needed to predict the behaviour of complex energy grids, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Allergen-derived DNA vaccines: mechanisms involved in mouse and human models' (ALLDNAVAC) targeting Fifth Framework.

assistant: **Abstract**

Aim of the project is to exploit the experience (of a previous EC-funded study) to investigate mechanisms of immunological modifications induced by allergen- (of Mite and Parietaria pollens) encoding DNA vaccines. Their effects will be directly investigated on APCs and on the effector cells responsible for allergic inflammatory response (namely Th2 and B cells, eosinophils and mastcells). This part of the study will be the prerequisite to design and evaluate novel DNA vaccine formulations (and approaches of pDNA delivery) in terms of their effectiveness to inhibit allergic Th2-mediated responses. These systems will be tested and calibrated in novel animal (mouse) and human (in vitro transfected cells) models. Quick and simple assay systems useful to monitor the efficacy of novel pDNA vaccines and their potential side-effects will be validated in view of a possible application to human allergic disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PARallel PAradigms and Run-time MAnagement techniques for Many-core Architectures', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The current trend in computing architectures is to replace complex superscalar architectures with small homogeneous processing units connected by an on-chip network. This trend is mostly dictated by inherent silicon technology frontiers, which are getting as closer as the process densities levels increase. The number of cores to be integrated in a single chip is expected to rapidly increase in the coming years, moving from multi-core to many-core architectures. This trend will require a global rethinking of software and hardware design approaches.This class of computing systems (Many-core Computing Fabric) promises to increase performance, scalability and flexibility if appropriate design and programming methodologies will be defined to exploit the high degree of parallelism exposed by the architecture. Other potential benefits of Many-core Computing Fabric include energy efficiency, improved silicon yield, and accounting for local process variations. To exploit these potential benefits, effective run-time power and resource management techniques are needed. With respect to conventional computing architectures, Many-core Computing Fabric offers some customisation capabilities to extend and/or configure at run-time the architectural template to address a variable workload.The 2PARMA project aims at overcoming the lack of parallel programming models and run-time resource management techniques to exploit the features of many-core processor architectures. To this purpose, a proper Consortium has been set up to gather the required expertise in the areas of system/application software and computing architectures.The 2PARMA project focuses on the definition of a parallel programming model combining component-based and single-instruction multiple-thread approaches, instruction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Toward Just, Ethical and Sustainable Arctic Economies, Environments and Societies' to be submitted under Horizon 2020.

assistant: **Abstract**

Arctic development of the past is persistent in inequitable practices, leaving scars from the impacts of social, economic and environmental inequality. In addition, Arctic development of today is occurring alongside the adverse effects of climate change within an integrated global system deficient in mechanisms for incentivising just transitions toward sustainable development.   With the goal of enhancing the governance capacity of the EU to mitigate this problem, JUSTNORTH brings together 16 partners from 7 disciplines to evaluate the viability of Arctic economic activities. The project will merge justice theories with sustainable development goals to enable EU policy coherence toward just transitions. This will be integrated with an investigation of the empirical realities of existing Arctic economic activities in 17 case studies using innovative research methodology, through conceptual, comparative, descriptive, correlation, policy, legal and interview-based analysis techniques. Though this, JUSTNORTH will offer policy, legal and regulatory pathway recommendations, by developing a frameworks from the reconciliation of the various ethics and value systems present in the Arctic, which can serve as a cornerstone for determining the viability of economic activities in the Arctic in line with the goals of sustainable development.  Ultimately, JUSTNORTH will provide both a negotiation tool for stakeholders to Arctic development (and a potential labelling standard for just/ethical regulatory standards) in its JUSTscore framework, which will create both transparency, documentation and standardisation for sustainable development across the Arctic (and the EU market).   Adhering to coproduction of knowledge with stakeholders throughout, JUSTNORTH will bring insights from indig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Ångström-Scale channels for Sensing, Ionic devices, and Chemistry in confinement' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Angstrom-scale fluidic channels, constructed with atomic precision, present an extraordinary opportunity to manipulate and understand molecular transport, ionic interactions, and reactivity at dimensions where quantum and classical phenomena converge. This proposal pioneers the exploration of these channels as advanced platforms for investigating interplay of ionic dynamics, driving innovations in memory devices, neuromorphic computing, sensing, and chemistry, with implications for energy-efficient devices and advanced materials. ANGEL will design mechano-sensors based on angstrom-scale confinement, where mechanical stimuli modulate ionic transport, advancing the understanding of ionic mechano-transduction and lay the groundwork for adaptive and bio-inspired devices. We will establish ionic memory systems with fluidic channels, to mimic neural processing, logic and learning. We will study the dynamic stimuli-responsive gating and the electron-ion coupling in the fluidic interface. Furthermore, we will explore photochemical reactions and photoemission phenomena under extreme spatial confinement. With real-time visualization and quantum sensing, we will uncover fundamental insights into molecular behaviour within confined environments. ANGEL will exploit the unique properties of ultra-confinement to achieve key four objectives: 1) Engineering artificial mechanoreceptive systems inspired by biological sensors, 2 Advancing ionic memory devices for neuromorphic computing, 3) Investigate ion gating in confinement by chemicals as well as through effects of ionic coloumb drag, and 4) Investigate confinement effects to modulate photoemission and drive chemical transformations.


**Keywords:** angstrom-scale, 2D materials, angstrofluidics, ions, ionic memory, ionic gating, confin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DARIAH ERIC Sustainability Refined' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Europe has a long and rich tradition as a centre for the arts and humanities. However, the digital transformation poses challenges to the arts and humanities research landscape all over the world. Responding to these challenges the Digital Research Infrastructure for Arts and Humanities (DARIAH) was launched as a pan-European network and research infrastructure. After expansion and consolidation, which involved DARIAH’s inscription on the ESFRI roadmap, DARIAH became a European Research Infrastructure Consortium (ERIC) in August 2014.The DESIR project sets out to strengthen the sustainability of DARIAH and firmly establish it as a long-term leader and partner within arts and humanities communities. By DESIR’s definition, sustainability is an evolving 6-dimensional process, divided into the following challenges:Dissemination: DESIR will organise a series dissemination events, including workshops in the US and Australia, to promote DARIAH tools and services and initiative collaborations.Growth: DESIR sets out to prepare the ground for establishing DARIAH membership in six new countries: the UK, Finland, Spain, Switzerland, Czech Republic and Israel.Technology: DESIR will widen the DARIAH research infrastructure in three areas, vital for DARIAH’s long-term sustainability: entity-based search, scholarly content management, visualization and text analytic services.Robustness: DESIR will make DARIAH’s organizational structure and governance fit for the future and develop a detailed business plan and marketing strategy.Trust: DESIR will measure the acceptance of DARIAH, especially in new communities, and define mechanisms to support trust and confidence in DARIAH.Education: Through training and teaching DESIR will promote the use of DARIAH tools and services.The DESIR consorti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'New measure technique for PMI (positive materials identification) analysing of alloys for metal and process industry by means of coulormetric sampling and spectrophotometric determination', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In the industry (metals industry, chemical industry, food and beverage industry) it regularly happens that alloys are mixed up. Use of wrong materials can lead to corrosion or mechanical failre, resulting into possible accidents, environmental damages and financial claims. In this project, a fast measure method for use on locations will be developed. Research will be required to develop the sampling electrode, the optics (colour measuring), electronics and software. Research will also be required to develop the electrolytes and chemical colour indicators, including optimalisation of tenavbility of solutions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multimodal multitAsk learninG for MultIsCale BATHYmetric mapping in shallow waters', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Accurate, detailed and high-frequent bathymetry, coupled with the important visual and semantic information, is crucial for the undermapped shallow coastal areas being affected by intense climatological and anthropogenic pressures. Regular UAV and satellite imagery have the potential to frequently and consistently map those areas to different extents and detail, providing ground breaking key information. However, optical properties of water severely affect images and refraction is the main factor affecting their geometry. Current Structure from Motion (SfM) based solutions for refraction correction are slow and costly. Satellite Derived Bathymetry (SDB) methods deliver faster results over huge shallow areas albeit in lower spatial resolution, failing to handle non-homogeneous seabeds. Recent methods based on Convolutional Neural Networks (CNNs) deliver either only the bathymetry or the semantics of the scene, tackling those problems separately and in one scale/modality at a time. They are mostly dedicated to satellite images, failing to address the challenges of shallow waters, being also inefficient for UAV images, preventing higher resolution results. MagicBathy will establish an advanced deep learning framework for low-cost shallow water mapping by developing a novel boundary-aware multitask, multiscale and multimodal learning approach for bathymetry and semantics together, exploiting single either UAV or satellite imagery. To overcome the domain gap, generalize and improve performance, self-supervised in-domain representation learning will be performed. To enhance the spatial resolution of low resolution satellite images and hence of the resulting bathymetric/semantic maps, a conditional generative adversarial network (cGAN)-based Super Resolution framework will be