RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structure guided inhibition of IDOL to treat atherosclerosis and the metabolic syndrome' (CHANCE) under Horizon 2020.

assistant: **Objectives**

The prevalence of the MetS and associated co-morbidities including cardiovascular disease has reached epidemic proportions in the developed and developing world. The cost of treating these conditions represents a substantial part of current European healthcare expenditure, and  despite recent advances, treatments for MetS-associated lipid disorders are far from optimal; mainstay lipid-lowering treatments (e.g. statins) reduce cardiovascular risk by only ~30%, and recently-introduced PCSK9 inhibitors are promising, but prohibitively expensive. Moreover, epidemiologic and genetic evidence suggests that these treatment modalities are associated with a significant increase in the risk for development of diabetes. Treatments for other MetS-associated comorbidities, including dyslipidemia, diabetes, obesity, and fatty-liver disease are far from optimal or lacking.   In ERC-CoG UNICOM we discovered that genetic inhibition of the E3-ubiquitin ligase IDOL protects mice from the detrimental development of multiple MetS-associated comorbidities. We therefore propose IDOL inhibition as a novel therapeutic strategy to concomitantly target multiple metabolic co-morbidities. However, absence of a high resolution IDOL structure has hampered structure-guided development of inhibitors. In CHANCE, we will capitalize on the high resolution 3D structure of IDOL that we recently obtained. Using this unique structure we aim to identify and validate small-molecule IDOL inhibitors by using a structure-guided development pipeline that combines  an established virtual ligand docking protocol, and in vitro and in vivo validation. Lead hits will be used for development of a business and IP strategy to ensure the sustainable development of IDOL inhibitors for treating the MetS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dais'2001' in the context of a Fifth Framework call.

assistant: **Objectives**

The project aims at enabling and supporting the exchange of knowledge, experience and expertise between young and experienced computer science researchers, and strengthening the links with European CS researches working outside their counties of origin, to take place at DAIS'2001 conference in Krakow, Poland. DAIS'2001 denotes the Third IFIP WG 6.1 International Working Conference on Distributed Applications and Interoperable Systems, that will be held on September 17th - 19th 2001. DAIS'2001 will provide a forum for researchers, application and platform service vendors and users to review, discuss and learn about new approaches, concepts and experiences in the fields of distributed processing and services. DAIS'2001 will focus on integration and interoperability of different platforms, services and applications, as well as on scalability and management issues and the growing importance of mobile and wireless protocols and applications.These research fields are now widely recognised as one of the hottest research areas, and gather a particular attention worldwide. They are also the key element of the EC's Information Society Technologies (IST) programme being part of the 5th-Framework Programme. Distributed applications representacore of the future Internet technologies and will be essential for forthcoming new services which will be developed e.g. in the context of the UMTS technology. DAIS'2001, besides its focus on current and future distributed platforrns, services and applications will endeavour to create a forum for presentations and discussing the advances of their integration and availability over wireless networks and technologies.An important socio-economic and scientific aspect is also the fact of organization of a prestigious international conference on lead
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Controlling earthQuakes'.

assistant: **Objectives**

According to the Centre for Research on the Epidemiology of Disasters (CRED), earthquakes are responsible for more than half of the total human losses due to natural disasters from 1994 to 2003. There is no doubt that earthquakes are lethal and costly. CoQuake proposes an alternative, ground-breaking approach for avoiding catastrophic earthquakes by inducing them at a lower energetic level. Earthquakes are a natural phenomenon that we cannot avoid, but –for the first time– in CoQuake I will show that it is possible to control them, hence reducing the seismic risk, fatalities and economic cost. CoQuake goes beyond the state-of-the-art by proposing an innovative methodology for investigating the effect and the controllability of various stimulating techniques that can reactivate seismic faults. It involves large-scale, accurate simulations of fault systems based on constitutive laws derived from micromechanical, grain-by-grain simulations under Thermo-Hydro-Chemo-Mechanical couplings (THMC), which are not calibrated on the basis of ad-hoc empirical and inaccurate constitutive laws. A pioneer experimental research programme and the design and construction of a new apparatus of metric scale, will demonstrate CoQuake’s proof-of-principle and it will help to explore the transition from aseismic to seismic slip. CoQuake is an interdisciplinary project as it takes knowledge from various fields of engineering, computational mechanics, geomechanics, mathematics and geophysics. CoQuake opens a new field and new line of research in earthquake mechanics and engineering, with a direct impact on humanity and science.


**Keywords:** Earthquake mechanics, soil dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'MOMENTUM - virtual, mobile CFO for small and medium enterprises' to be submitted under Horizon 2020.

assistant: **Abstract**

MOMENTUM is a virtual and mobile CFO platform fthat helps Small and Medium-sized Enterprises (SMEs) ensure financial liquidity and growth on EU market.MOMENTUM is an innovative online and mobile platform for registered SMEs. The Platform can be accessed on mobile platforms (iOS and Android), as a separate SaaS (Software as a Service) on the Atsora website or directly from the bank website (as an extension of electronic banking).The most important features of MOMENTUM platform:1) seamlessly integrated with bank account, online accounting and other SaaS business applications in order to provide real-time view on business and help with day-by-day decisions2) simplifing business planning, budgeting, forecasting and performance tracking for small businesses and startups3) enabling user to set business goals, compare performance to industry benchmarks and see all key numbers in an easy-to-use dashboard, so he knows exactly what's going on in his businessThe Platform integrates together SMEs and business partners (banks and other medium and large enterprises providing a wide spectrum of services and products to the SME segment). Integration with banks is an important part of the system. The entrepreneur can decide to provide more information about his business to the bank and receive thereby easier access to finance on potentially better conditions. Therefore, the result of the implementation MOMENTUM platform on the European market will be facilitated access to finance for SMEs.In the opinion of the applicant, use of the proposed application should improve conditions for the implementation of new technological, organizational and marketing actions, which is contributing to meeting the objectives set by the EU to stimulate innovation activities of SMEs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional Nanomaterials via Controlled Block Copolymer Assembly' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We outline an ambitious 5 year interdisplinary research programme that introduces a fundamentally new platform to the fabrication of nanoelectronic and liquid crystal devices, current areas of intense scientific and technological interest. The new approach involves the use of block copolymer micelles and block comicelles prepared by Crystallization-Driven Living Polymerization (CDLP) processes. This novel method allows unprecedented access to well-defined micelle architectures (with size control, narrow size distribution, and access to segmented structures that possess heterojunctions). Crosslinking will also be used to optimize micelle mechanical properties where necessary. The new platform offers very promising advantages over competitive methods for realising nanomaterials these include ambient temperature synthesis and solution processing, easy control of dimensions and aspect ratio, electronic properties, and semiconductor/semiconductor or semiconductor/dielectric junction fabrication. In addition, the use of hydrophilic coronas should, in principle, allow the self-assembly processes and subsequent manipulations to be performed in water.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of a high power ultrasound system for the low-cost, fast, effective and quality drying of fruit and vegetables', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Dried food is a major element in modern food processing and a staple ingredient for an increasing variety of foodstuffs. Dried food offers many advantages for the mass production of commercially prepared goods, not least cheaper transportation costs, longer storage life and ease of use. However modern drying methods, such as Accelerated Freeze-Drying, prove costly, time consuming, labour and energy intensive, limitations which can prove more crippling for SMEs. There is a need to provide EU dried food SMEs with a technology which will help to remain competitive in the EU and global dried food sectors. Preliminary research conducted to date suggests that the application of high power ultrasound (HPU) for the dehydration of porous materials may be very effective in processes in which heat-sensitive materials such as foodstuff have to be treated. HPU is a powerful technology that is safe and environmentally friendly, efficient and economical. High-intensity ultrasonic vibrations are capable of affecting mass transfer processes with the result of increasing the drying rate of materials, thereby permitting the use of lower temperatures or shorter treatment times.  This process thus shows promise for assisting the dehydration of fruits, vegetables and other foods, preserving the quality attributes of the food products and during this project a HPU based pre-treatment method will be developed. A prototype will be built and tested prior to conventional drying processes to improve the added value of the dried product and enable faster, more cost effective and energy efficient drying of food, which will empower and equip SMEs from the European dried food industry to compete against the growing threat of global competition and large multinationals. It will also result in increased
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AN INTELLIGENT PREDICTION SYSTEM FOR THE SMART EFFICIENT USE OF RESOURCES IN CITIES' to be submitted under Horizon 2020.

assistant: **Abstract**

Both public administrations and private investors are increasingly looking for smart solutions for an efficient management of different kinds of resources, under the double motivation of economic savings and communitarian regulations. This trend sustains the market of Smart City technologies to a foreseen volume of 27.5bil€ in 2023, representing a huge opportunity for our business.Datapole is a French company specialized in intelligent systems. We developed PREDISMART, an advanced integrated ICT solution for the efficient management of different kind of resources, including Wasts, Energy, Water, Services and Stock. PREDISMART contributes to the deployment of smart cities, enabling the monitoring, analysis, forecast and management of the different resources, resulting in savings up to 25% for the final users.PREDISMART is an innovative intelligent prediction platform developed by Datapole to forecast and aid to decision-making based on advanced statistical models to obtain previsions for smart cities. The opportunity for PREDISMART is based on smart cities and energy efficiency. It is forecasted that cumulative global investment in smart city technologies is expected to total $174.4 billion in 2023. We expect to raise our benefit up to €, enabling us to hire 22 people in the 2018-2022 period, and we expect to reach the payback for the investment associated to this project in 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Analysis of the cell cycle-regulating transcription factor drtf1/e2f - characterization of the dp-3 sub-family of proteins' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The transcription factor DRTF1/E2F plays a crucial role in regulating cell-cycle progression. In one hand, many of the genes activated at the G1/S transition contain binding sites for this transcription factor and in several cases these sequences are necessary for periodic expression. In the other hand, molecules that regulate cell-cycle progression negatively, such as pRb and related proteins, and positively, such as cyclins and cdks, are able to regulate its activity. Transcription factor called DRTF1/E2F results from the interaction of two families of proteins, E2F and DP. The interaction is synergistic with respect to both DNA binding and E2F site-dependent transactivation. A recently defined member of the DP family, DP-3, encodes different isoforms which arise by differential processing of the DP-3 mRNA in the coding sequence, together with processing events which occur in the 5' untranslated region. No functional role has been described for these regions, although it is possible that they are involved in the translational regulation of the DP-3 isoforms. The research proposed in this application aims to assess if the variation in the 5' untranslated region regulates translation. The molecular details of control will be addressed, and the functional physiological implications for DRTF1/E2F activity during cell cycle evaluated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent Mold for Productivity Enhancement' under Seventh Framework.

assistant: **Concept**

The constant demand for diversified/personalised consumers' goods leads to decrease time-to-market, and to plastic injection molds with smaller batch production, with no stock acceptable for cost and quality reasons. This generates huge productivity losses in the molding industry: - Tool Tuning is too long for tool makers before delivery of a turn key mold. - New production run set-up time is too long and generate too much scraps, due to different “operator and machine” parameters. Many approaches are currently adopted to reduce mold design and production time, but none of them addresses directly the parts productivity enhancement, where “trial & error” is still the most employed engineering approach. The innovative approach of Mold4ProdE is to develop and assess a methodology to tool makers, for them to propose and deliver quicker turn key intelligent molds, to clients with a reasonable extra cost, and offering them significant productivity enhancement. Technically, it aims at applying modern data mining techniques for modelling polymer injection molding process, based on virtual data coming from virtual sensors implemented in a CAD model of the mold. The purpose is to: - optimize the number and position of sensors in the mold - implement and assess the concept “Virtual Mold Signature” by using the data driven models, built from experimental data collected during production runs with sensors embedded in process equipments. Mold4ProdE shall also provide dedicated and optimised components for tool instrumentation, data collection and treatment. The project results will deliver the basis to efficiently use the intelligent moulds. This will move the European mold makers to the knowledge based service industry, identified as the key factor to increase their competitiveness.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electronic Municipal Information Services - Best Practice Transfer and Improvement Project' under Fifth Framework.

assistant: **Concept**

E-MuniS is a best practice transfer and improvement project for European municipalities. It aims at improving the best practices of the EU municipalities in the IT based administrative work and services to citizens and transferring the results to SEE municipalities in the Balkan region, integrating it to the EU municipal network. Improvement of municipal work and services to citizens is essential for the Information Society development in SEE, as identified by the SEEmunIS pre-project. The aim will be achieved through best practice transfer, adaptation and dissemination of a back office - e-municipality office (EDMS, Interface tool for external IR, City Mayor's information network) and front office (Citizens' tool set for communication with the city, Interae to municipal IR, Municipal and city web-sites, Information kiosk).OBJECTIVESE-MuniS ultimate goal is to provide opportunities for user-friendly implementation of the IT achievements in municipal administration working processes and services to citizens. It aims at improving the best practices of the EU municipalities in the field and transferring the results to SEE municipalities from the Balkan region, integrating it to the EU municipal network. It meets the requirements of the IST Support Activities IST - 2000-VIII.1.6 - VIII.1.5, and accompanies activities under IST 2000 - I.311 Smart government. The needs of the SEE municipalities for improvement of the administrative work and services to citizens were identified by the SEEmunIS pre-project (SouthEast European Municipal Information Infrastructures, 1999/2000). The E-MuniS Consortium includes municipalities and IT companies from EU and SEE.DESCRIPTION OF WORKThe project strategy consists of transferring and adapting best practice IT applications for municipal wor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'New, realistic and robust models for cryptocurrency volatility'.

assistant: **Objectives**

Forecasting cryptocurrency volatility is a topic of interest in quantitative finance. A growing number of studies argue that compared to equty price cryptocurrency prices are to a large and perhaps abnormal degree driven by sentiments. However, econometric studies focus on forcing conditional volatility models developed for equity return volatility to fit on cryptocurrency data despite being aware that estimation techniques developed for analyzing equity price or commodity price volatility lack robustness and do not work as intended. Is it possible to propose solutions to deal with the mentioned shortcomings? Is it possible to suggest a new family of models? If so, how? The purpose of New, realistic and robust models for cryptocurrency volatility is to answer these questions by suggesting new and more realistic conditional volatility models accompanied with reliable cross-disciplinary estimation techniques to forecast cryptocurrency price volatility. What is novel and innovative about the suggested framework is that contrary to the current literature our point of departure is the empirical features observed in cryptocurrency prices combined with a useful tool, namely, artificial neural networks used to measure sentiments. Our aim is to build a machine that produces discrete sentiment phases each day using news articles and internet search data. Once we have identified the number of phases and determined, which phase an observation at a given time-period belongs to following neural network estimation, we can estimate the model parameters, jumps and filter out the continuous conditional volatility process contemporaneously using particle filtering techniques. Besides academics, this proposal is also relevant for regulators and investors as they can learn a great deal by u