RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'High Strengh Resorbable Ceramic Bone Cement' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

Calcium phosphate cements are in clinical use for filling non-load bearing bone defects in crania- andmaxiofacial surgery. Two types of cements are distinguishable: cement formed at pH values lower than form brushier (DCPD) and above pH values of 4.2 they form hydroxyapatite (HA), the mineral component of bone and teeth. Cements are thermodynamically non-restorable due to the stability of HA under physiological conditions. Degradation is only possible by acid producing bone remodelling cells (osteoclasts) and is limited to the surface since cells cannot penetrate the cement. In contrast, brushier cements areresorbable under physiological conditions, because brushier has a much higher solubility product at pH7.4 compared to HA. This has been demonstrated in vivo. Up to now, no commercial brushier bone cements are available for clinical use, largely because of its comparatively low mechanical strength. The rate of crystal growth rate of brushier is 500 times that offhand and therefore these cements set very rapidly. Compressive strengths of brushier cements reported in literature are lower than 10 Map and setting times can just be increased to values of 3-5 minutes by these of retardants at the price of further reduction in the already low mechanical properties. Furthermore, unrelated components can lead to a low pH in the implant site, which raises toxicity concerns in some implantation sites, e.g. the spine. Clearly however if mechanical properties can be improved brushier cements will offer the substantial advantage of being restorable and hence replaceable by new bone. The overall aim of this project will be to investigate the powder physics of this cement system in order that mechanical performance and handling characteristics are improved. Surface charge modifiers a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dual-channel paper-based electroanalytical platform for multiple myeloma care', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Multiple myeloma (MM) is an aggressive type of cancer of plasma cells where fast diagnosis and treatment monitoring is vital, especially given the overall low survival rate. Proteasome, a multi-catalytic complex essential in damaged protein degradation, has been recently established as a biomarker for MM, in which elevated levels have been observed in blood plasma of unhealthy individuals, as well as its impaired activity has been target for treatment alongside regular chemotherapy. PADMME addresses increasing contributions on proteasome electrochemical recognition and aims to develop novel interdisciplinary technologies translatable into POCT systems for MM care. For this, we propose the development of sensitive and selective dual-channel platforms comprising conductive polymeric fiber biosensors integrated on paper-based microfluidic supports to simultaneously detect quantity and specific activity of proteasome in blood plasma. Paper supports ensure disposability and ease of commercialization, whilst incorporation of microfluidic paths allows low sample volume requirements and in situ pre-treatment steps. Conductive polymeric fiber scaffolds provide increased signal resolution for the construction of biosensors, necessary for the recognition of low concentrations of the biomarker. Then, investigating proteasome at the dual-channel platform in drug-treated and untreated MM cell lines will demonstrate how changes in quantity and specific activity are specifically linked to the disease dynamics. The last step will comprise validation of the technology for analysis in blood plasma, technology able to improve overall monitoring of MM disease progression and therapeutic efficiency, crucial to overcome delays in treatment due to drug resistance complications. Training throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Does climate change enhance the nanoparticle toxicity of freshwater biofilms?' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Aquatic ecosystems are threatened by multiple environmental stressors including pollutants and climate change. Considerable progress has been made in understanding the environmental impact of many stressors in recent years, yet new, potentially powerful, toxicants such as engineered nanoparticles (ENPs) continue to emerge in aquatic systems and their effects on these ecosystems remain poorly understood. The release of ENPs into the environment is accelerating  , and as the global climate warms, the combined effects of both stressors (ENP + temperature increase) could have significant consequences for aquatic life. As a major step into understanding the climate change-enhanced environmental impacts of ENPs in aquatic ecosystems, we focus on the responses of fluvial biofilms -microbial consortia that drive aquatic primary production and respiration and thus, control nutrient conditions  - as key points of ENP entry in to aquatic food webs. The central goal of NanoTOX is to elucidate how much river warming will affect fluvial biofilms at genetic, metabolic/functional and structural levels, and how the presence of environmental concentrations of ENPs may further stress the communities. The combination of multiple stressors (increased temperature and ENP) is expected to have a profound influence on the fluvial biofilms performance. This objective will be achieved through an innovative, interdisciplinary approach using an array of methods from the fields of ecotoxicology (ecology and toxics), molecular, functional ecology and nanotechnology will be applied. The proposed interdisciplinary study is a major first step in opening a new research field focussing specifically on biofilms as entry points to the food web and assessing ENP impacts under future climate scenarios. NanoTO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'PILOT PLANT PRODUCTION OF CONTROLLED DOPED NANOPOROUS CARBONACEOUS MATERIALS FOR ENERGY AND CATALYSIS APPLICATIONS' (POROUS4APP) under Horizon 2020.

assistant: **Objectives**

The main idea of POROUS4APP project is based on the fabrication of functional nanoporous carbonaceous materials at pilot plant scale from natural resources (polysaccharide). The process for nanoporous carbon fabrication is already well known as one of the POROUS4APP partner has developed the STARBON® technology at TRL5 which consist of swelling, drying and pyrolysis of natural resources and in this case Starch. What POROUS4APP project will bring to the European community is the development of new metal/metal-oxide doped-nanoporous carbonaceous materials based on a known technology. This technology needs to be upscaled and modified to enable a full flexibility of the material characteristics to be applied to various industrial applications. The use of abundant renewable resources like starch has been proven to be a low cost and reliable raw material source for industrial production of carbonaceous materials having porosity in the nanometer range. In POROUS4APP it will be intended to produce not only carbonaceous nanoporous materials but carbonaceous material with enhanced functionality by using impregnation and sol/gel strategy. This will allow POROUS4APP materials to reach the challenging requirements of state of the art high added value materials at lower cost for applications in energy storage such as lithium-ion battery and also in chemical catalysis process. These applications need materials with well defined porosity to reach high efficiency level of their functional systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Long Beamtime Experiments for Nuclear Astrophysics' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of LOBENA is to measure key properties needed for understanding nuclear processes in the Cosmos. Nuclear Astrophysics plays a key role in our quest to understand the origin and distribution of the chemical elements in our galaxy. Nuclear processes are crucial for understanding the energy production in the universe and are essential for describing the creation of chemical elements from the ashes of the Big Bang. Uncertainties in the nuclear physics can therefore influence our understanding of many astrophysical processes, both those involving stable stellar burning phases and explosive phenomena such as X-ray bursts, gamma-ray bursts and supernovae.In LOBENA (LOng Beamtime Experiments for Nuclear Astrophysics) I will initiate a series of studies in Nuclear Astrophysics, which have in common the need for long beam times and the use of complete kinematics detection of several particles emitted in reactions. The core of the project will focus on the systems 8Be, 12C and 16O where today key open questions of great importance remain to answered. These questions can be addressed by reactions induced by low energy (<5MeV) beams of protons and 3He on light targets such as 6,7Li, 9Be,  10,11B and 19F using a newly developed complete kinematics detection procedure. The department of Physics and Astronomy in Aarhus provides a unique scene for doing these measurements since it provides accelerators where long beam time can be guarantied.  LOBENA will also include complimentary experiments at international user facilities such as ISOLDE (CERN), KVI (Groningen), JYFL and (Jyväskylä).With this ERC starting grant proposal I wish to start up my own group around Nuclear Astrophysics experiments in house and at international user facilities. With two Post Doc.s and a Ph.D. I will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Formation of a giant tungsten deposit: Metal sources and fluid evolution at Panasqueira, Portugal' (TUNGSTEN) under Seventh Framework.

assistant: **Objectives**

Tungsten is a strategic resource crucial to a wide range of industries due to its unique physical properties, especially for the production of alloys and carbides. World tungsten supply is currently somewhat volatile owing to the market domination by a single nation (China), as well as recently imposed export quotas that contribute to market instability. The disappearance of EU tungsten would result in full dependence of several critical industries on imports from abroad. In this context, understanding the distribution of tungsten at local and regional scales within Europe has been deemed strategically important by the European Union.The regional distribution of tungsten is controlled by the location of the granites that act as the source of tungsten. The local distribution of tungsten is controlled by the mechanisms that lead to tungstate precipitation. Therefore, understanding metal provenance, and the processes of metal mobilization and deposition is essential to determining where mineralization will occur. This study will provide the first state-of-the-art quantitative data on how fluids evolve in a world-class tungsten deposits (Panasqueira) and, based on those results, will provide constraints on genetic processes and on the distribution of tungsten. Furthermore, this study will apply cutting-edge analytical techniques to define the isotopic composition and age of ore minerals, providing better understanding of the source of metals, which is also one of the defining factors in the regional distribution of tungsten.This project will position the European Union at the forefront of research in the geology of tungsten and establish a network of researchers with the background and tools to continue to advance this field in close collaboration with the industry partners
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Programmable edge-to-cloud virtualization fabric for the 5G Media industry' to be submitted under Horizon 2020.

assistant: **Abstract**

The focus of 5G PPP H2020 remarkable research so far has been largely on the required advances in network architectures, technologies and infrastructures. Less attention has been put on the applications and services that will make use of and exploit advanced 5G network capabilities. 5G-MEDIA aims at innovating media-related applications by investigating how these applications and the underlying 5G network should be coupled and interwork to the benefit of both. In this respect, 5G-MEDIA addresses the objectives of 1) capitalizing and properly extending the valuable outcomes of the running 5G PPP projects to offer an agile programming, verification and orchestration platform for services, and 2) developing network functions and applications to be demonstrated in large-scale deployments, based on 3 well-defined use cases (in the areas of immersive media and VR, smart production and user-generated content, and UHD over CDN) of diverse requirements and particular interest for the consortium partners. Based on the adoption of the open innovation approach, 5G-MEDIA platform will be offered to third parties to develop, combine, verify, deploy and validate media applications by utilizing the SDK capabilities and Service Platform offerings.Finally, 5G-MEDIA plans to create an ambitious business impact with the introduction of Streaming as a Service concept, built on top of a well-defined, consortium-wide exploitation plan and supported by the complementarity of expertise of its consortium, representing key industrial sectors in the network and media domains: telecom operators (OTE, TID), cloud providers (SILO), PaaS/SaaS vendors (IBM), service providers (ENG), application developers (NETAS), broadcasters (RTVE), SMEs (IINV, NXW, IRT, BIT) and research centers (UCL, UPM, CERTH). I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Novel and combined domestic grey water treatment and heat recovery system suitable for cost effective  installation in 90% of European households' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

AquaConserver concept addresses the twin problems of energy and water conservation faced by all citizens of the EU27 and offer us, as Europe’s leading SME Plumber, equipment suppliers and consulting Associations, at this specific time, an opportunity to bring a new demand-led, offering to our customers, requiring high levels of expertise and training to install correctly and efficiently. Our concept involves the development of a low cost, retro-fittable to 90% of domestic dwellings, water recycling system that is capable of the re-use of showering and bathing water thereby saving up to 50% of personal washing water usage and >50% of the associated heating energy usage AND that is capable of re-using filtered grey water from bathing/showering for toilet flushing thereby saving up to 35% of overall household water usage’.  The key issue and barriers to large scale uptake of these systems is their high installed cost, decades pay-back periods and their ongoing maintenance issues and that they are so large and require internal locations or are fitted in outside pits that they are not suitable for most consumers houses/flats. We believe that we as the Associations that represent the majority of installers can develop a low cost, low maintenance AquaConserver grey water recycling and heat recovery system that can be affordably installed in 90% of all domestic households and therefore become the market leader.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Energy when needed, modern eco-efficient production machine for brazing heat exchangers' (ENEED-2001), addressing dissemination and exploitation.

assistant: **Impact**

ENEED-2001-Energy when NEEDed, modern eco-efficient production machine for brazing heat exchangers (Delphi, Alcan, CRF, Fin-Machine, SAET, Solvay, UTC, Carrier) For energy saving and environment reasons, innovation in heat exchanger brazing process is required. Today, a 50 m long braze line -electrostatic fluxer, thermal degreasing oven with fumes incinerator and braze furnace- is working 24 h a day and 340 days a year. Only 10% of the energy is used to braze parts. The idea is to save the maximum of energy (10 GWh/year and per machine producing 600000 parts/year) with a new heating system (induction, resistance & laser combination) used only when needed, a material with low melting point temperature (500°C i/o 600°C), a catalytic converter for fume's treatment, one 4 m long machine integrating heating and fume's treatment, giving full flexibility (one piece flow), improving job skills and work conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Satellite-based change detection and predictive monitoring of infrastructure grids based on high resolution data' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

LiveEO will offer a holistic monitoring service for infrastructure networks based on satellite data and machine learning algorithms to identify external threats to the grid and predict future impacts by adding time series analytics to our services. The service will enable rapid change        detection (e.g. storm monitoring) to quickly assess the location and extent of damage and slow change detection to facilitate the prediction of potential risks. We will make use of optical and radar data to offer services in real time, regardless of weather. The solution requires the        development of AI-based change detection algorithms that evaluate data at different points in time i.e. time-series and are able to detect patterns and abnormalities in the data with high precision. To do this automatically, the development of an automated process chain, able to transform        data into actionable insights for our customers is part of the solution. Insights will be made available via mobile and web apps.


**Keywords:** Risk management,Service innovation,Space services and products,Satellite-based change detection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Resolution Pharmacology and Physiology of MCTR in Arthritis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Chronic inflammation may result from failure of the host response to engage pro-resolving pathways. The current treatment armamentarium for chronic inflammatory conditions may lead to immune suppression. Thus, identification of novel therapeutics that control inflammation without immune suppression will provide an attractive alternative approach. This is especially important since incidence of these conditions increases with an ageing global population. In planaria, mice, human peripheral blood and milk I recently uncovered a new family of endogenous molecules, named Maresin Conjugates in Tissue Regeneration (MCTR). These potently regulate white blood cell responses, promote the resolution of acute inflammation and accelerate tissue regeneration. The aim of this Starting Grant is to identify pathways that lead to failed resolution in inflammatory arthritis, as a prototypical chronic inflammatory condition. The hypothesis is that MCTR biosynthesis is dysregulated in inflammatory arthritis, leading to an unbridled host response, chronic inflammation and tissue destruction. This proposal will employ a multipronged approach to test this hypothesis by 1) Determining MCTR regulation in self-resolving and delayed-resolving arthritis; 2) Investigating the host protective and tissue regenerative actions of MCTRs in inflammatory arthritis; 3) Establishing the MCTR biosynthetic pathway and 4) Determining the regulation if its components during self-limited and delayed-resolving arthritis. Anticipated results will uncover novel pathways that become dysregulated during failed resolution. Results from this Starting Grant will also identify targets and new therapeutic approaches that will engage pro-resolution programs as well as tissue regeneration in conditions characterised by pers