RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of Novel Sensors for Contaminant Detection in Water using Near Infrared Light and Aquaphotomics' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Although water is the most widespread molecule in biological systems, it’s interaction with light remains poorly understood. Water is prone to contamination through biological processes, industrial practises and malicious tampering. Surface water reservoirs are exposed to contamination by thousands of micropollutants from pharmaceutical, agricultural and natural origins. Aquaphotomics is a new scientific discipline that concerns the rapid and comprehensive analysis of water-light interaction as a potential source of information for better understanding of the biological world. This proposal investigates the potential use of Aquaphotomics combined with Near Infrared Spectroscopy (NIRS) and Near Infrared Chemical Imaging (NIR-CI) for early detection of contamination in water. Knowledge gained on the theory and application of Aquaphotomics acquired during the outgoing stage will be transferred to the EU during the incoming stage. This knowledge will be used in the development of real-time, multi-contaminant detectors based on NIRS and NIR-CI. Such real-time monitoring would enable dynamic modelling of water systems, which is not currently available, for increased understanding of the behaviour of contaminated water systems. It is envisaged that this work will lead to the development of a centre of excellence in Aquaphotomics at UCD and provide a protocol for the development of sensors based on NIRS and NIR-CI for rapid detection of contamination in water.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding groundwater Pollution to protect and enhance WATERquality' (UPWATER).

assistant: **Innovation**

Among the available freshwater resources, groundwater (GW) plays a key role in providing water supplies and livelihoods to respond the pronounced water scarcity. GW pollution by chemicals (organic and inorganic) and biological agents (viruses and bacteria) originating from human activities is a widespread worldwide problem. The scientific and technological goals of the UPWATER project are (1) to provide scientific knowledge on identification, occurrence and fate of pollutants in the GW with cost-efficient sampling methods based on passive samplers for chemicals and pathogens; (2) to develop sources apportionment methods to identify and quantify the pollution sources, including Compound Specific Isotopic Analysis (CSIA) and (3) to validate and assess the performance of bio-based engineered natural treatment systems designed as mitigation solutions.  The monitoring and mitigation solutions will be validated in 3 case studies (DK, GR and ES), representing different EU climate conditions and a combination of rural, industrial and urban pollution sources. The existing hydrogeological models will be updated with innovative water quality modelling tools, allowing the simulation of decision-making scenarios under multiple stressors and climate change projections. The scenarios will also include the expected impacts of scaling-up the mitigation solutions and the adoption of other non-technological preventive measures devoted to minimise the release of chemicals at source (chemicals regulation, taxation, consumption campaigns, public procurement, etc). The exploitation of specific UPWATER results will lead to expected mid-term outcomes including among others: updating the EU chemical priority lists, scaling-up the pilot bio-based solutions to demonstration scale, the adoption of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Investigation of the nonlinear dynamics of sigma-delta modulators' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This research project attempts to apply nonlinear dynamical systems theory to sigma-delta modulators nonlinear systems whose increasingly widespread use in signal conversion is unfortunately not matched by a rigorous theoretical foundation. Most analyses of sigma-delta modulators rely on linearising assumptions and cannot explain such important practical effects as oscillations, multiplicity of solutions and instability In my Ph.D.studies I examined such effects in a related system (DPCM, which like sigma-delta modulation is modelled by a noninvertible piecewise-continuous map) with the aid of theories of nonlinear dynanmics and in particular those of noninvertible maps. I now propose to extend this work to develop an improved theoretical understanding firstly of sigma-delta modulation, and more generally of noninvertible piecewise- continuous discrete-time dynamics in electronic systems. Training content (objective, benefit and expected impact) I will extend and capitalise on my existing background to develop an expertise in practical and theoretical aspects of electronic systems which are of huge importance to industry, with the important benefit of industrial contact throughout my research. Links with industry / industrial relevance (22) The host group is partially funded by Analog Devices, one of the leading manufacturers of sigma-delta modulators, for research in this area, affording me the possibility of direct and valuable contact with industry concerning my research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Network of Science with and for Society National Contact Points 2019-2020' in the context of a Horizon 2020 call.

assistant: **Objectives**

Science with and for Society has a vital role to play in bringing together a wide range of stakeholders in order to build capacities and develop innovative ways to connect science to society through Responsible Research and Innovation measures. This demands that the Science with and for Society National Contact Points (NCPs) are able to orientate in the wide area of policy behind the programme, its topics and research areas as well as in Horizon 2020 rules and regulations and in addition, they need to have extensive knowledge of the different groups of stakeholders, in order to be able to fulfil their job. The proposal focuses on identifying and sharing good practices and raising the standard of proposals by organising joint activities of NCPs. The consortium ensures a balance of experienced NCPs and newcomers in order to build on knowledge and enhance skills and competences of all NCPs within the programme. This will result in more consistent and improved NCP services which will enhance participation in Science with and for Society calls.


**Keywords:** Horizon 2020,  Science with and for Society,  National Contact Points, NCP,  Responsible Research and, Innovation,  RRI,  Ethics, Open Access,  Gender,  Governance,  Education,  Communication,  Innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Studying Resistance to Cancer Therapeutics in Prostate Cancer' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Several new therapies have been recently approved for the treatment of castration-resistant prostate cancer (CRPC) but drug resistance invariably develops and eventually causes death. Currently, the knowledge on the molecular mechanisms underlying resistance is limited; this is an area of urgent unmet medical need to allow improved treatments for patients. This study proposes a multidisciplinary effort led by the Marie-Curie fellow that will aim to identify genomic aberrations associated with drug resistance. We hypothesize that disseminated circulating tumor cells (CTCs) and DNA (CTD) from blood and plasma will contain real-time genetic information about the changes occurring in the tumor and can be used as an early biomarker of progression or responsiveness to treatment, with minimal invasiveness and discomfort to the patient. Firstly, next generation sequencing data of fresh-frozen CRPC biopsies collected prior to, and after progression on abiraterone and/or enzalutamide treatment and patient-matched archival hormone therapy-naïve samples collected at The Institute of Cancer Research, will be analyzed together with the computational oncology group at University of Trento (PI: Dr Demichelis). Second, single CTC isolation will be performed using a research protocol that is novel and developed in collaboration with Dr Terstappen (University of Twente) and Dr Tibbe (biotechnology company Aquamarijn) in the setting of the FP7 grant “CTCtrap”. The fellow aims to genetically characterize CTCs and CTD over time by high-throughput targeted deep sequencing to elucidate the processes underlying metastasis and evolution of resistance in prostate cancer. Thirdly, the fellow will perform studies on selected genomic aberrations to functionally confirm their role. The results could
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Epigenetic treatment of neoplastic disease' (EPITRON).

assistant: **Innovation**

Chromatin is epigenetically modified to regulate gene expression. Upstream signals induce complex patterns of enzyme-catalyzed modifications of DNA and histones, key protein components of chromatin. These epigenetic modifications create docking sites for other regulators and form a code that specifies transient or permanent (and heritable) patterns of genome function. In addition, epigenetic enzymes modify the activity of major transcription factors. Emerging evidence causally links altered epigenetic functions to oncogenesis, suggesting that chromatin regulators and upstream pathways are critical targets for developing novel anti-cancer drugs (epi-drugs). The demonstration that the in vivo anti-cancer activity of histone deacetylase inhibitors (HDACi's) is causally linked to induction of cancer cell-selective apoptosis has provided proof-of-principle for the potency of epi-drugs. This Consortium (EPITRON) will define and validate the concept of epigenetic cancer treatment" from the mechanism to animal models accurately reproducing human leukemia, and extend this concept to solid tumors, in animal models of breast cancer. We will follow a multidisciplinary and integrated approach, i) define the mechanism of the anti-leukemic action of existing epi-drugs and the role of individual epi-enzymes, ii) molecularly define the tumor selectivity of HDACi-induced TRAIL death ligand, iii) validate TRAIL action in mouse models and establish "reporter mice" to monitor the in vivo activity of epi-drugs iv) generate novel epi-drugs and nuclear receptor ligands, iv) search by genome-wide epigenetic technologies novel epi-targets with emphasis on leukemia and leukemogenic oncoproteins, v) analyse the potential of epi-drug sensitization and crosstalk, and vi) analyse the response mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Flow in the tumor microenvironment: Linking mechanobiology with immunology' (LYMPHIMMUNE) targeting Seventh Framework.

assistant: **Abstract**

Tumors often engage the lymphatic system to invade and metastasize. The tumor-draining lymph node (dLN) may be an immune privileged site that protects the tumor from host immunity, and lymph flow draining tumors is often increased, enhancing communication between the tumor and the sentinel node.  In addition to increasing transport of tumor antigens and regulatory cytokines to the lymph node, increased lymph flow in the tumor margin causes mechanical stress-induced changes in stromal cells that stiffen the matrix and alter the immune microenvironment of the tumor. In this proposed project, we will investigate the interplay between lymphatic drainage and flow-induced mechanotransduction in the tumor stroma that may synergize to promote tumor immune escape by appropriating lymphatic mechanisms of peripheral tolerance. We will address the hypothesis that lymphatic drainage and flow-induced mechanotransduction in the tumor stroma synergistically promote tumor immune escape by altering the immune microenvironment, and that targeting lymphatic drainage from the tumor may represent a new avenue for tumor immunotherapy. For the latter, we will develop strategies to limit or block lymphatic flow in the tumor microenvironment and characterize their ability to improve the efficacy of tumor immunotherapy by dampening local immunosuppression in the tumor stroma and tumor-draining lymph node (dLN). We will combine in vivo mouse models and intravital imaging with engineered in vitro microenvironments and nanoparticle-based targeting strategies in three broad aims designed to constitute several PhD and postdoctoral projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a cement hydration sensor' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

To improve quality in construction this project will develop an in-site cure sensor for continuously monitoring internal moisture and hydration reactions incurring concrete. It shall be based on a modified form of Time-Domain-Reflectometry, which extracts frequency information from sensor response, and thus probes microwave molecular dynamics. The commercial potential of this work will be a concrete cure sensor that provides continuous readout of moisture and hydration both in the laboratory and the field. This could lead to lower construction costs through elimination of excessive wait times and design safety factors to compensate for uncertain quality control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Taking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Our proposal is based on the idea that real-time functional neuroimaging can be used to train patients to regulate their own brain activity via neurofeedback training and thus modulate the brain networks of mental disorder, restore function, improve symptoms and promote resilience. We have brought together the core groups that have been instrumental in the development of methods for real-time functional imaging and fMRI (functional magnetic resonance)-based neurofeedback and have led the initial clinical applications in neuropsychiatric disorders. Our proposal has three main components, the development and refinement of methods for the real-time analysis and feedback of fMRI data and combination with other imaging modalities (WP2), the adaptation of fMRI mapping techniques to localise disease-relevant networks and development of protocols for their self-regulation through neurofeedback (WP3) and the assessment of feasibility and clinical effects in several mental disorders that are characterised by dysfunctional brain systems for motivation, emotion regulation and social communication and by important therapeutic gaps (autism spectrum disorders, alcohol addiction, post-traumatic stress disorder, childhood anxiety disorders, binge-eating disorder) (WP4). We will also explore the potential transfer of (laboratory-based) imaging feedback training into everyday settings through ambulatory and assistive technologies such as electroencephalography (EEG) and gaming (WP5). We will engage with potential users of these technologies (healthcare professionals and providers, medical instrument and software manufacturers, patient and carer associations) through several workshops, liaise with regulatory authorities and disseminate findings to the academic and user communities in WP6.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'HIGH-TC  JOSEPHSON NEURONS AND SYNAPSES: TOWARDS ULTRAFAST AND ENERGY EFFICIENT SUPERCONDUCTING NEUROMORPHIC COMPUTING' (JOSEPHINE), addressing dissemination and exploitation.

assistant: **Impact**

We aim at realizing a novel class of high-temperature Josephson junctions (JJs) that behave as artificial neurons and synapses. These JJs will enable a new neuromorphic computing paradigm, in which neural networks are much faster, more energy efficient and compact than with non-superconducting approaches, and possess novel capabilities (combined sensitivity to light, magnetic and electric fields). Via these rupture ingredients, JOSEPHINE will dramatically enhance the impact of neuromorphics on its broad range of projected applications: from artificial intelligence (where it would allow supercomputer-level processors at a fraction of the environmental cost) to the control of autonomous vehicles, the Internet of Things, and novel medical applications. That constitutes the long-term vision for the science we propose. To reach that goal, we will use different strategies to realize high-Tc Josephson junctions whose weak-links are active and can be changed ""in operando"" by external stimuli. Those strategies include ""weak links"" modified by a nanoscale redox reaction, by the motion of domain walls in a ferromagnet, or by locally doping a graphene or a 2D semiconductor. Once realized, these JJs will be implemented and tested in neural networks to demonstrate their performance and their transformative effect on neuromorphics. The proposed strategy exploits recent breakthrough results of the partners (physical effects that will be implemented) and synergizes their complementary expertise via a multidisciplinary approach that marries traditionally distant disciplines: neural network engineering, superconducting electronics, and various facets of solid-state physics (superconductivity, magnetism, Dirac materials, and electrochemistry).""


**Keywords:** superconducting electron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chromatin Dynamics in Development and Disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The cell nucleus is organized and compartmentalized into a highly ordered structure that contains DNA, RNA, chromosomal and histone proteins which make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies such as cancer. Higher order organization of chromatin results in chromosomes which occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging question is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from academia and industry with cross disciplinary expertise and capabilities.