RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reconstitution and Structural Analysis of a Minimal Mechanosensitive Focal Adhesion Complex' to be submitted under Horizon 2020.

assistant: **Abstract**

Focal adhesions (FAs) are receptor complexes that couple the extracellular matrix (ECM) to the actin cytoskeleton, allowing inside-out and outside-in signaling between cells and their environment. FA formation is triggered by activation of integrin receptors, which interact with cytoplasmic ligands to connect with the actin cytoskeleton and regulate numerous signaling pathways. FA maturation requires force transduction between the actin cytoskeleton and ECM, which results in protein recruitment, likely through conformational changes and force-dependent protein deformation. The molecular mechanisms regulating this process are largely unknown, though many of the key components have been identified and are well characterized in vivo. I will carry out a hierarchal reconstruction of the core FA components, namely talin, vinculin, and integrin, both alone and in the presence of actin filaments or a force-generating actomyosin network. This will allow direct observation of (1) how core components of FAs assemble and regulate each other, (2) how actin impacts the formation and structure of this core complex, and (3) the effect of force on the assembly, overall complex structure, and conformational states of individual proteins. Interactions between key proteins will be analyzed both biochemically and structurally using cryo-EM in a step-wise manner to obtain a comprehensive image of FA assembly. Recent technical advances have made cryo-EM an ideal tool for solving high-resolution reconstructions of macromolecular complexes like FAs. Structural approaches will be augmented by light microscopy experiments, to provide a dynamic view of complex assembly and regulation. By using multidisciplinary, innovative approaches, this project will address both functional and structural questi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'ThErmAl Probes Of fractional quantum hall Transport' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In a strong magnetic field and at extremely low temperatures, a two-dimensional sheet of electrons can transition into a strongly correlated state: the fractional quantum Hall (FQH) state. The one-dimensional edge of such a sheet is by itself a viable experimental platform for controlled studies of a wide range of quantum phenomena. Recent experimental developments have enabled detailed thermal transport experiments for probing the properties of such FQH edges. Despite this progress, many questions on edge energy propagation, equilibration, and redistribution remain unanswered.  The theoretical TEAPOT project will address these questions by introducing new observables - heat noise, mixed noise and delta-T noise -for disordered transport on general FQH edges. The main goal is to use these promising quantities as novel and complementary tools for probing emergent transport phenomena, not directly or not uniquely related to the electrical charge.   TEAPOT will be led by the experienced researcher (ER), as a postdoc project in collaboration with the Supervisor: an expert on quantum thermodynamical processes in nanoscale devices. The ER has recently developed a theoretical model connecting the propagation of charge, heat, and charge noise on general FQH edges. With this substantial preparation, TEAPOT will reach its goal by generating a full theoretical description of the interrelated edge propagation of charge, heat, charge noise, heat noise, delta-T noise, and mixed noise. This description will be derived by the ER and the Supervisor, combining chiral Luttinger liquid techniques with concepts in quantum thermodynamics.   TEAPOT will enable novel ways to design and analyze FQH experiments, improving the fundamental understanding of strongly correlated quantum behaviour on t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'The use of molecular biomarkers in early lung cancer detection (EARLY LUNG CANCER)'.

assistant: **Innovation**

The overall goal of the project involving 12 Partners is to determine if specific genetic changes in lung carcinogenesis are detectable in the respiratory epithelium of individuals who have an increased risk of developing lung cancer. Partners are enrolling 1200 individuals with a very high risk of developing lung cancer i.e. Second Primary Lung Cancers (SPLC) in 12 clinical centres in Europe. The recruited individuals will be followed-up over 3 years, 1-3% per year will develop SPLC (-100 SPLC). Specimens obtained will be 'banked' and assessed for a range of molecular/pathological markers considered to be involved in carcinogenesis. We have tackled the question of early detection on a molecular pathway approach and plan to examine; oncogenic pathways and cell cycle regulation, genetic instability, angiogenic and growth factors, signal pathways, post-transcriptional regulation genomic expression profiling and genotyping.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'More Automated Factories' in the context of a Horizon 2020 call.

assistant: **Objectives**

The objective of the project is to develop new ways to implement quality validation of aircraft products in a more efficient manner, reducing non-recurring costs, reducing the need of man-hours and the involvement of manipulation by an human operator, reducing lead times and flexibility of the processes, through minimization of test means dependency trying to maximize the usage of the current Aircraft computers, and implementing new concepts for the automation of quality and validation tests on the aircraft, through artificial vision and robotic collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International Doctoral Training in Mathematical Sciences in Paris' (MathInParis2020) under Horizon 2020.

assistant: **Objectives**

COFUND MathInParis2020 programme creates and scales up excellence networks to attract to Paris promising Doctoral students, under solid selection and mentoring practice, and ensure high-level Doctoral training and successful professional insertion. FSMP has a long-standing experience for project management and the present programme aims at significantly scaling up its present COFUND MathInParis programme which has initiated a growing success. MathInParis2020, as an internationally visible portal to Paris mathematics research, promotes the increase and dissemination of a new generation of international mathematicians trained in Paris, creating a new network of young innovating Doctors integrated in European Union who will develop novel key areas of expertise and act as scientific ambassadors worldwide. Ambition, mobility and curiosity, awareness of the impact of mathematics in economy, taste for risk taking, innovation and entrepreneurship are as many qualities that our laureates will acquire.MathInParis2020 creates exceptional follow-up and mentoring conditions thanks to dedicated personnel and development of the scope and modes of provision in Doctoral education, offering training in mathematics and helping to catch the many academic and intersectoral opportunities. We develop new mechanisms for transition of doctoral students to the widely increasing number of new emerging careers and promote public-private mobility by specific actions, in particular with intense intersectoral exposure.MathInParis2020 bridges academics and private sector partners, companies, banks, with the major objective of leading its laureates to successful careers. MathInParis2020 builds up innovation and new knowledge for the future in European Union.


**Keywords:** Mathematics, Applied mathema
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Maximizing freshness and minimizing losses of agriculture products through automated atmosphere management in storage facilities'.

assistant: **Objectives**

Today, the fresh produce supply chain is highly unsustainable: 33% of the produced fruit and vegetables is either lost or wasted, of which 10% occurs during long-term storage. This loss also has a major financial impact on the food industry. For stored apples, pears and blueberries alone, the global economic loss equals €6.1 billion per year. However, a significant part of current storage losses could be prevented if only continuous monitoring of stored products was possible so that appropriate measures can be taken.In the MAX-FRESH project, we will develop the innovative ISS-Monitor: world’s first automated multi-species trace gas sensor that can simultaneously and in real-time detect low levels of 7 volatile gases that indicate ripening, fermentation, damage or rotting of stored fruit. Once unfavorable conditions are detected, the ISS-Monitor will provide automated alerts to enable timely and effective interventions by its customers. The ISS-Monitor has the potential to reduce losses of stored fresh food by 50%, extend storage life with 20%, and reduce post-harvest chemical treatments with 50%.The MAX-FRESH project builds on a functional prototype of the ISS-Monitor which demonstrated proof-of-performance in a relevant environment. During the MAX-FRESH project, we will take the final steps required to launch the ISS-Monitor on the market. To do so, we apply for €2.2 million (77%) from the EC. The MAX-FRESH project will be performed by a complementary consortium of 3 market-leading industrial partners and 1 academic partner, combining cutting-edge technologies with unique expertise. After completing the MAX-FRESH project in 2023, the ISS-Monitor wil be ready for market launch. By doing so, the ISS-Monitor will make an impact on the global food production system by cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'USharePark: smart secUres system to SHARE PARKing places in private garages' (USharePark), addressing dissemination and exploitation.

assistant: **Impact**

USharePark is a peer-to-peer (P2P) smart parking solution intended to optimize the usage of available private parking spaces. This business project is driven by two Spanish companies, Ayanet and Garage Scanner. The first of them is a company with more than 30 years of experience in SW and ICT solutions. Garage Scanner is a technological start-up created in 2007, and it is the initiator of USharePark. Our alliance was motivated by the potential synergy, since Garage Scanner needs to develop certain tasks in those fields where Ayanet has expertise, and Ayanet seeks to diversify its line of business through USharePark. We have already signed a contract with an important parking lot owner in Spain to manage 600 parking spaces in three different facilities, starting in September 2015, and players in other cities and countries have shown interest in the system. The next step of our joint venture is to develop an international commercialization strategy which will enable the penetration in the key markets in Europe and US. The total smart parking revenue in these areas was estimated at €6.26 billion in 2014 and it is expected to grow at a CAGR of 17.9% to reach €38.25 billion in 2025. The specific P2P smart parking market is estimated to grow at a CAGR close to 30%, from €100 million to €1.87 billion during the same period. 57.24 million parking spaces are already offered by the top 20 app providers in these areas, on behalf of 29.65 million users. Therefore, we can assure that specific commercial opportunities will arise for parking operators like USharePark and their supporting ecosystem. Our solution connects drivers and parking owners to get the most of the availability of empty spaces. Owners receive an extra income by renting their parking spaces while not being used, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Illuminating GENome Organization through integrated MIcroscopy and Sequencing' (GENOMIS).

assistant: **Concept**

In human cells, two meters of DNA sequence are compressed into a nucleus whose linear size is five orders of magnitude smaller. Deciphering how this amazing structural organization is achieved and how DNA functions can ensue in the environment of a cell’s nucleus represent central questions for contemporary biology.Here, I embrace this challenge by establishing a comprehensive framework of microscopy and sequencing technologies coupled with advanced analytical approaches, aimed at addressing three fundamental highly-interconnected questions: 1) What are the design principles that govern DNA compaction? 2) How does genome structure vary between different cell types as well as among cells of the same type? 3) What is the link between genome structure and function? In preliminary experiments, we have devised a powerful method for Genomic loci Positioning by Sequencing (GPSeq) in fixed cells with optimally preserved nuclear morphology. In parallel, we are developing high-end microscopy tools for simultaneous localization of dozens of genomic locations at high resolution in thousands of single cells. We will obtain first-ever genome-wide maps of radial positioning of DNA loci in the nucleus, and combine them with available DNA contact probability maps in order to build 3D models of the human genome structure in different cell types. Using microscopy, we will visualize chromosomal shapes at unprecedented resolution, and use these rich datasets to discover general DNA folding principles. Finally, by combining high-resolution chromosome visualization with gene expression profiling in single cells, we will explore the link between DNA structure and function. Our study shall illuminate the design principles that dictate how genetic information is packed and read in the human nucl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bottom-up manufacturing of artificial anti-tumor T cells' (ArTCell).

assistant: **Innovation**

T cells play a central role in anti-tumor immune protection. While their ability to target and eliminate emerging tumor cells is increasingly recognized, fully-established tumors can efficiently evade T cell response. Significant efforts spanning several decades of research have been made to develop T cell-based therapies manufactured from donor-derived T cells. The use of tumor-directed T cells engineered to express chimeric antigen receptors (CARs) represents, to date, one of the most successful applications for treatment of chemoresistant cancers. However, several major drawbacks, including economic factors, suboptimal functioning and life-threatening side effects, are still hindering the full potential of T cell-based therapies. To address this issue, we aim to generate Artificial T cells (ArTCell) that will mimic the anti-tumor function of a T cell-based therapy but in a safer, more efficient and less expensive product. ArTCells will incorporate two key features of activated T cells into Giant Unilamellar Vesicles (GUVs): the specificity of tumor cell recognition and the cytotoxic activity achieved through death ligands and cytolytic proteins. Functionalization of the GUVs will be confirmed by immunofluorescent labelling of membrane proteins (i.e., TRAIL, LFA-1 and CAR) and detection with flow cytometry. The morphology of ArTCell will be monitored via cryo-EM, SEM, and confocal microscopy. The ability of ArTCell to target and kill tumour cells will be thoroughly validated in vitro by a combination of functional and high resolution live imaging assays as well as in vivo with two cell line- and patient-xenografts mouse models. The ArTCell could allow to circumvent many of the current technological limitations that hinder a more wide-spread applicability of cell-based
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multi-Element Transmit and Receive Antennas' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project will analyse the feasibility and evaluate the performance of introducing multi-element adaptive antennas into mobile terminals in a combination with adaptive base station antenna arrays (including transmit diversity) for 3rd generation mobile communication systems with emphasis on UMTS, DS-WCDMA.Objectives:The main objective of the METRA project is to analyse the feasibility and evaluate the performance of introducing multi-element adaptive antennas into mobile terminals in combination with adaptive base station antenna arrays, including transmit diversity, for 3rd generation mobile communication systems with emphasis on UMTS. The performance analysis will be evaluated in terms of increased data rates, increased spectrum efficiency and increased coverage range whereas the feasibility will be analysed in terms of technical complexity of mobile and base station hardware, cost benefit analysis, impact on standardisation of future phases of EDGE/UMTS and pseudo-real time demonstrationWork description:The METRA project will perform multiple-input and multiple-output (MIMO) matrix radio channel measurement to clarify the characteristics of the MIMO channel matrix in various mobile communication scenarios.The project will thoroughly investigate state-of-the-art research in antenna array processing technology. The performance of various transmit and receive options will be analysed under realistic conditions, i.e. propagation, MAI, and other UMTS system aspects.The project will also aim at developing novel hybrid solutions that can be implemented in future phases of UMTS looking into technological implementation aspects.The METRA project will perform pseudo real-time demonstration of transmit and receive diversity concepts for UMTS. The outcome of the METRA project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'On-chip efficient storage of electrical energy with negative super-capacitance in 2D material systems'.

assistant: **Objectives**

We propose the combination of two performance boosters: (i) negative capacitance principle, exploiting  ferroelectricity in doped high-k dielectrics, as developed and validated in 2D devices of our ERC Advanced grant Millitech, and, (ii) 2D graphene electrodes to enhance the performance of supercapacitors in on-chip 2D material systems, in an innovative device called N-supercap. While negative capacitance was until now explored mainly for digital and analog low power electronics, we propose to exploit NC in ferroelectric/dielectric/2D capacitors for on-chip energy storage to support autonomous sensory nodes. This will result in a versatile energy storage systems for IoT Edge AI  systems, to enable a large scale deployment in tens of billions without maintenance costs, in a scalable and eco-friendly technology.  The proposed PoC will serve as first step in the creation of startup that will aim at using such N-supercaps in various IoT node applications in environmental, industrial and healthcare monitoring. We have set a team of experts to exploit this technological breakthrough into the creation of a startup, based on a road to commercialization.


**Keywords:** energy storage on-chip, supercapacitors, ferroelectrics, negative capacitance, high-k dielectrics, graphene 2D electrodes