RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Republic of Scientists" and the highways of European Scientific Communication in Galileo's age"' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The project is aimed at using electronic resources to publish on-line an accurate map of the network constituting the Republique des letteres in the age of the so-called Scientific Revolution. The researcher and the host institution aim at constructing a prototype of a multi-task database that will be published on the web site http://histsciences.univ-paris1.fr/The database will take into account evidence gathered from scientific and learned correspondences so as to define and highlight the contents the networks and the ways of transmission of cultural and scientific information in early modern Europe. It will collect data about personal biographies, scientific institutions, instruments, natural specimina and objects, places related to scientific practice. In formation will be arranged and available in a spatial and geographical fashion, so as to construct a map of the information fluxes in the European cultural space, following the model of a traffic stream visualized on a luminous screen.The database is aimed at being user friendly. It is conceived as an open-access tool (that is open to contributes by the scholars in the field as well as by general users). It will also be accessible to different levels of use, so as to provide information for scientific popularisation, scientific museums and science centres. The highways of science project can be of strong interest for Europe. Indeed, it is meant as strengthening scientific exchanges and integration. It implies the cooperation between international institution s and learned communities. In providing the necessary historical background, it will help European communities of today to rebuild and renovate centuries-old styles and patterns of cooperation. The project will also provide the best opportunities for Federica F
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Application of rigorous quantum theory to 'Walden inversion' organic reactions'.

assistant: **Objectives**

Research objectives and content There are a lot of organic reactions which have clasically been benchmark reaction . These reactions called SN2 or 'Walden inversion' reactions involve inversion of the methyl group during the reaction. My proposal is apply rigoruos quantum scattering theory to these four-atom reactions. I want to extent the arrangement-channel hyperspherical coordinate theory to these reactions and perform systematic and extensive calculations on them. Quantities calculated will include state-to-state reaction probabilities, cross sections and rate constans together with lifetimes of the reactions complexes. This job will demand new theoretical and computational challenges on how to treat the methyl umbrella vibration, how to deal with the j and k quantum states of reactants and products and how to tackle sytematically the other vibrational degrees of freedom. Training content (objective, benefit and expected impact) All these interesting problems can be realistically and systematically dealt with and will benefit much by exploiting the powerful computational facilities at UCL. I will learn the most modern methods of theoretical chemistry, computer modelling and their applications. New theoretical methods for studying SN2 reactions will result. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Artificial diets for the production of natural enemies (predatros and parasitoids) of greenhouse pest insects' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The use of chemicals to control insect pests generates many drawbacks concerning agriculture, environment and human health. These drawbacks could be greatly reduced by using natural enemies to control pest insects. Biological control using insect predators (e.g., Coccinellids, heteropterans) and parasitoids (e.g., Trichogramma,...) Is already used in practice and has proved to be efficient in many situations. The extension of biological control is strongly limited by the necessity to produce large numbers of entomophagous insects at competitive cost. Efforts to shorten the production line have been performed by using alternative hosts/prey or artificial diets, but in many cases empirically established artificial diets, if any, are not suited for good quality production of entomophagous insects.  In recent years, an increasing interest was observed worldwide for artificial rearing of parasitoids and predators of agricultural pest insects, and more and more research teams, especially in the USA, have developed programmes on such subjects, with encouraging results. To preserve the scientific and economic independence of the European Union, it is necessary to develop European research strategies in this field. A solid background exists in Europe on the artificial rearing of parasitoids and predators and different teams have been implicated in this research for years.  The objective of this project is to define artificial diets for the in vitro production of some important predators and parasitoids based on an analytical and rational approach. Artificial diets for different predators (1 coccinellid and 3 heteropterans) and one aphid parasitoid will be based on biochemical analyses of their natural or substitution food. Reliable quality control parameters of the entomophages
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Final act of the autophagy symphony: Whole-organism orchestration of autophagy termination', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

When an organism experiences physiological stresses, such as nutrient starvation, it activates several mechanisms to promote its survival. One of these mechanisms is autophagy, which is a catabolic pathway conserved from yeast to man that functions as a recycling system during normal physiology, and which helps provide nutrients to sustain essential cellular processes during starvation. Although autophagy is an intensively studied process that plays a major role both in normal development and in a wide variety of diseases, several important aspects of autophagy remain to be elucidated. For instance, whereas the vast majority of studies have focused on how cells regulate the activation of autophagy, it remains largely unknown how cells and organisms shut off autophagy in response to returning nutrient availability. The limited knowledge of autophagy termination is partly due to a lack of available tools and appropriate methods. Addressing these challenges will not only provide important insight in this fundamental aspect of the autophagic process, but may potentially also identify new targets for development of drugs to manipulate this phase of autophagy. In FINALphagy I will develop new genetic and computational tools to quantify and manipulate the temporal dynamics of autophagy in an entire organism. I will unravel key mechanism of autophagy termination in individual cells within a tissue and dissect how this connects to systemic signaling and behavioral changes. This will generate a comprehensive toolbox for time- and space-resolved manipulation and quantification of autophagy levels, produce a whole-organism map of autophagy responses at the tissue-level, and conceptualize our understanding of the dynamics of autophagy regulation in an entire organism during changing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Antimicrobials from Endophytes of Northern Medicinal Plants' (TEJAM).

assistant: **Innovation**

Antibacterial resistance is spreading globally at an alarming rate and continues to increase. New potent antimicrobials are therefore continually needed. In recent years, new antibacterial compounds have mainly been additions to the existing classes of drugs and truly new structures have rarely been developed. The derivatives of existing drugs however raise bacterial resistance much faster than completely new compounds. Pharmaceutical industry has little interest in developing new structures due to high investment and low profit expectancy. To overcome the chronic problem of antibiotic resistance, totally new compounds and approaches are required, involving collaboration of researchers from various disciplines, as well as high societal investments. The TEJAM project involves the highly experienced Fellow, Dr. M.V. Tejesvi (University of Mysore, India) and Departments of Biology and Chemistry at the University of Oulu, Finland. Both participants (Fellow and Host Institution) have a similar history of screening for bioactive compounds from endophytes, internal plant microbes. The project aims at i) discovery of totally new antimicrobial, as well as antioxidant and antihypertensive compounds from one of the richest untapped natural sources, endophytes, ii) development of new methods for efficient drug discovery from endophytes and iii) increased international collaboration in the area of discovery of novel bioactive compounds. During the TEJAM project, new high-throughput methods will be tested and used for screening and developing new leads for the pharmaceutical industry. TEJAM is utilizing and optimizing state-of-the-art methods, such as HT robotic screening and metagenomics, on the endophyte research. The project is closely linked to two consortia focused on research o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project '“NextGenBioPest” - Next Generation Biopesticides for the control of the most “difficult-to-manage” pests and pathogens in fruits and vegetables' (NextGenBioPest).

assistant: **Concept**

Plant pests and pathogens damage agricultural production and endanger food security. Their control relies heavily on the use of synthetic insecticides, leading to a negative environmental impact. Developing new methods for pest and pathogen control is therefore essential to safeguard human health and meet the challenge of increasing crop yields, while reducing the use of chemical pesticides. The overarching objective of the NextGenBioPest project is to meet this need by delivering novel and improved products, methods, and practices for the rational control of the most difficult-to-manage arthropod pests and pathogens, with substantially reduced pesticide use. The project will provide a new toolkit for plant protection in key vegetable and fruit crops including diagnostics for pest and pathogen identification and incrimination, novel Biological Control Agents and methods to augment their performance in the field, RNA-based pesticides, Low Risk/Green chemicals, plant resistance inducers and innovative agronomic and ecological practices. These innovations will be integrated with existing approaches, to achieve effective, environment friendly and sustainable crop protection. They will be validated in large field studies, with both their efficiency and socioeconomic impact assessed. Demonstration fields, extensive training and modern targeted communication channels, will enable the appropriate dissemination and uptake of the outcomes to the stakeholders and end users. Data protection and commercialization strategies will ensure their exploitation. These goals will be achieved by integrating leading institutional and industrial partners with drivers of pest control programs. The multidisciplinary and multi-actor team will exploit their diverse expertise, access to extensive p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DEVILS (Development of Vhbr engines Innovative Lubrication System)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Aircraft Engines are normally assisted by a number of complementary systems that have to guarantee performance throughout the whole flight envelope of the aircrafts for which they are designed. Among these systems Oil lubrication and heat management system is the most important due to its roles:•Remove the heat generated in the highly loaded rolling bearings and the gears found in the Engine power and accessory gearboxes•Lubricate bearing and Power and Accessory gear boxes.The current trend of developing aircraft engines that consume less fuel put a lot of pressure on the oil lubrication system cooling requirements due to higher speeds, loads and temperatures in engines. This is much more true for Very High By-pass Engines due to the integration of high-power gearboxes (allowing high by-pass ratio) and high-power starter-generators. For this reason Engine manufacturer are deeply looking to innovative design for oil lubrication and heat management system implementing architectures that are able to meet the new cooling and lubricating requirements without negatively impacting the Engine weight or operational and maintenance costs. The overall objective of project DEVILS Project is to research, develop and validate the robustness of a new variable oil flow approach towards the design an innovative variable flow oil pump to be integrated in a high performance aircraft lubrication systems architecture with the aim of reducing fuel and oil consumption. Objective of DEVILS project is as well to research, implement and validate smart fault detection and health monitoring algorithms to assist the system in reducing oil low flow rate needs and prognostic functions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Identification of key regulators of the caveolar-endocytic pathway from cell surface to lipid droplets : Physiological importance for intracellular storage of nutrients'.

assistant: **Innovation**

Nutrients overload leads to adipocyte hypertrophy and excess of adipose tissue causing deleterious consequences known as the metabolic syndrome. During my post-doc, we showed that the fat cell surface and the lipid droplet can communicate through an ER-ind ependent endocytic caveolar pathway of critical importance in targeting cholesterol to lipid droplets. This caveolin-dependent route could therefore function more generally to supply lipids to adipocyte lipid droplets. In order to identify key regulators o f this pathway, we will design a screen assay based on microscopy imaging. We will use caveolin fused to the green fluorescent protein (GFP) and the lipid droplet marker adipophilin fused to the red fluorescent protein (RFP). In lipid-loading conditions, c aveolins associate with fat bodies, resulting in the co-localization of the two proteins and yellow colour (merge of green and red emitted fluorescence). By combining this assay with RNAinterference of kinases genes, we hope to identify knock-downs which r everse this phenotype by screening for distinct red and green fluorescence patterns. An important issue is to compare these kinases requirements with the ones involved in caveosomes and clathrin-coated pathways.This project also aims at testing the physiol ogical importance of this caveolar-endocytic pathway in lipid droplet storage in vivo. Thus, we will identify lipid species able to stimulate association of caveolins with lipid bodies (starting from unstimulated conditions where caveolin and adipophilin d ont co-localize). We will in this case screen for induction of yellow colour. The physiological contribution of this pathway in nutrients intracellular storage will be evaluated by measuring concentrations of these lipids candidates in fat bodies isolated fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'HPC for Energy' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project aims to apply the new exascale HPC techniques to energy industry simulations, customizing them, and going beyond the state-of-the-art in the required HPC exascale simulations for different energy sources: wind energy production and design, efficient combustion systems for biomass-derived fuels (biogas), and exploration geophysics for hydrocarbon reservoirs.For wind energy industry HPC is a must. The competitiveness of wind farms can be guaranteed only with accurate wind resource assessment, farm design and short-term micro-scale wind simulations to forecast the daily power production. The use of CFD LES models to analyse atmospheric flow in a wind farm capturing turbine wakes and array effects requires exascale HPC systems. Biogas, i.e. biomass-derived fuels by anaerobic digestion of organic wastes, is attractive because of its wide availability, renewability and reduction of CO2 emissions, contribution to diversification of energy supply, rural development, and it does not compete with feed and food feedstock. However, its use in practical systems is still limited since the complex fuel composition might lead to unpredictable combustion performance and instabilities in industrial combustors. The next generation of exascale HPC systems will be able to run combustion simulations in parameter regimes relevant to industrial applications using alternative fuels, which is required to design efficient furnaces, engines, clean burning vehicles and power plants. One of the main HPC consumers is the oil & gas (O&G) industry. The computational requirements arising from full wave-form modelling and inversion of seismic and electromagnetic data is ensuring that the O&G industry will be an early adopter of exascale computing technologies. By taking into account the comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Kainate and ampa receptor trafficking and recycling at brain synapses (KAR-TRAP)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Glutamate receptors are replicated in important neurological diseases and believed to play central roles in brain development, learning and memory. With their associated intracellular signalling molecules, they attract considerable interest is potential therapeutically targets in neurological conditions such as stroke, chronic neurodegenerative diseases, Alzheimers disease, and schizophrenia. These are major health problems, particularly among elderly, that strongly call for new therapeutic approaches. The present project intends to provide an experimental basis for development of therapies that act by reducing or increasing the number of glutamate receptors at the synapse. Specifically, attempts will be made to resolve the mechanisms underlying insertion into and removal of glutamate receptors from somatic membranes. This may reveal molecular targets for fine-tuning of synaptic transmission in specific brain areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Birth of the Marimacho: Modernismo’s Trans* Cultural Productions in Latin America'.

assistant: **Concept**

Birth of the Marimacho: Modernismos Trans* Cultural Productions in Latin America analyzes the emergence of a new gender expression in early-twentieth-century Latin American literature, science, and visual culture: the marimacho. In the Hispanic tradition, marimacho is the umbrella notion that may refer to a sexist slur as much as a modern form of non-binary gender, a transmasculine identification, or a lesbian identity. This project examines the aesthetic construction of this hybrid, counter-cultural, and gender-dissident figure in an extensive cultural repertoire that includes novels, plays, films, leaflets, medical studies, prison and mental hospital records, poems, and newspaper and tabloid articles. I seek to increase the understanding of the regions politics of gender and sexuality during the modernizing era (1880s-1930s), that is, before the solidification of LGBTQ activism, pride literature, and minority social movements of the Global 1960s. In response to the new gender dynamics led by cosmopolitan networks of first-wave feminism, the keepers of gender normativity created the marimacho as a monstrous version of conventional masculinity. The main objective of this research is to investigate why a broad range of cultural materials named queer women, non-binary individuals, and trans* men as marimachos, as gender hackers that put at stake the futures of heteronormativity, reproduction, and family life.


**Keywords:** Nineteenth-Century Studies, Sexuality Studies, Transgender Studies, LGBTQ Memory, Medical Humanities, Orientalism, Masculinity, History of Sexology, Queer Popular Culture, Fin-De-Siècle Studies