RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanomedicine Approach to Normalize Erythrocyte Maturation in Congenital Anemia by messenger RNA' to be submitted under Horizon Europe.

assistant: **Abstract**

Messenger RNA (mRNA) has recently proven itself as a prophylactic modality that can be rapidly developed and employed with high efficacy and low toxicity. Compared to DNA-based gene therapy, mRNA has significant advantages including higher intrinsic safety (non-integrating), lower cost of development, and less stringent regulatory requirements for clinical approval. In the NANEMIAR project, we take advantage of these benefits to kill 2 birds with 1 stone: first, we develop a first-of-its-kind nanomedicine for congenital anemia, a group of rare, inherited blood disorders characterized by ineffective red blood cell production. Our proposed bone marrow-targeted mRNA-based therapy contributes to the first Horizon Europe strategic plan (2021-2024) for new and advanced therapies for non-communicable diseases and is expected to be a vast improvement over current treatment options in terms of efficacy and safety. Second, we provide critical knowledge on targeted non-viral polynucleotide delivery, with a platform that can be exploited for next-generation cell and gene therapy in a broader context. To achieve this, our consortium combines the unique cell-targeting and mRNA knowledge from the Dutch Biotech Mercurna with two excellent research partners (from Spain and France) who have demonstrated expertise in the field of anemia. By focusing on the well-recognized rare disease model, beta-thalassemia, and combining an established mouse model, patient material, and previous drug development experience we build a convincing case to treat congenital anemia.


**Keywords:** mRNA, erythropoiesis, lipid nanoparticles, targeting, health, congenital anemia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Soil Transformations in European Catchments' in the context of a Seventh Framework call.

assistant: **Objectives**

SoilTrEC proposes to develop an integrated model of soil processes that describes key soil functions. These functions are defined in the EC Soil Thematic Strategy as essential ecosystem services for the well-being and economic success of the EU. The key science advances are to develop, from first-principles, computational models that integrate soil erosion, solute transport, carbon dynamics and food web dynamics within an open-source modelling framework. This framework will provide the platform, together with existing GIS capacity, for a prototype simulator at EU-scale to assess soil threats and evaluate approaches to mitigation. This physical-based modelling will be integrated with new advances in decision support developed from life cycle and economic assessment methodologies for natural resources. A key conceptual advance of this project is to quantify soil stocks, their formation, loss and functions within the context of the earth’s Critical Zone. This encompasses the terrestrial environment from the top of the biosphere’s tree canopy to the bedrock delineating the lower bounds of freshwater aquifers. SoilTrEC will link 4 EU field sites that describe key stages within the life cycle of soil formation, its productive use and degradation. Existing data sets will be augmented with targeted process studies in order to provide the data sets to validate the integrated model of soil processes. These process studies will be integrated with results from additional EU, USA and Chinese field sites to compare soil processes and rates as they vary with lithology, climate and land use. These sites and their teams will be integrated through shared results and an international research training programme into a global network of Critical Zone Observatories. This programme of resear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'ADVanced On-board diagnosis and Control of Autonomous sysTEms'.

assistant: **Concept**

The objective is to enhance safety, reliability and efficiency of autonomous robotic systems (Autonomous Underwater Vehicles and Autonomous Ground Vehicles) by the implementation of the ADVOCATE II solution:- An open and modular software architecture for diagnosis and control, to allow easy integration of AI techniques with pre-existing solutions, using new technologies based on XML/SOAP standards, extended for taking into account time constraints and priority management;- Diagnosis modules, fully compatible and based on different AI techniques;- Friendly Tools to increase genericity in allowing dynamic configuration of the application. To validate ADVOCATE, trials will be performed using operational prototypes in real conditions.OBJECTIVESThe global objectives of the project are, in order to enhance the level of reliability and efficiency of autonomous robotic systems:· To construct an open, modular and generic software architecture for autonomous robotic systems diagnosis and control. It will be designed to meet time constraints requirements and to allow easy integration of innovative, reliable and tested AI techniques with pre-existing solutions· To develop or improve a set of intelligent diagnosis modules fully compatible with this architecture and tested in operational application.. To develop friendly tools in order to enlarge genericity of the solution in allowing dynamic configuration of the application. To set and make use for tests and demonstration of operational prototypes in order to prove efficiency of this solution in several application fields. Dissemination and promotion of these results could be a first step for standardisation of the ADVOCATE architecture.DESCRIPTION OF WORKThe ADVOCATE 2 main objectives will be achieved through the following goals:-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-spectral remote system for real-time alarm and monitoring of natural hazards' under Horizon 2020.

assistant: **Concept**

Techcom Srl was founded in Italy in 2017 with the aim to design and develop environmental monitoring solutions, providing installation and maintenance service for landslides, debris flows, sudden floods, avalanches, glaciers, etc. Over the past 10 years, our team of engineers and expert physicists have developed products and solutions based on the latest sensing technologies and integrated with our in-house software to serve customers with a high level of customization. We have evolved throughout the years performing >100 land monitoring projects with national and international scope reaching >50 active sites in 5 countries. With the ambition to continuously provide solution to monitor territories with new disruptive technologies that will result in more accurate detection for the natural hazards, we seek to bring to the European market a new revolutionising monitoring system. Our innovation, SENTINEL, consists of a single device that integrates: (1) 3 complementary sensing technologies that allow optimum performance and coverage under any light and weather condition; (2) Artificial Intelligence software that delivers real-time decision support and action response adapted to the risk severity; and (3) data portal that is accessible on all devices with 24/7 live stream transmission to customers and interaction with local authorities and decision makers. SENTINEL reduces by 75% equipment costs and 25% maintenance costs, gives ≥90% accuracy and fastness, and provides recommendations based on AI to allow customers (e.g. local and regional municipals, civil protection, railways, ski resorts) to rapidly detect and give an alert response within seconds, thus guaranteeing security and safety at all time. SENTINEL will bring our company international expansion and growth, reachi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Long-lived quantum memories for space-based applications' (QSPACE).

assistant: **Concept**

Quantum experiments in space open up numerous interesting technological and scientific possibilities in the last years. Long-distance quantum communication (QC) is one of the first applications that would benefit from these advances as quantum information can be transferred over very long distances by satellites. However, this range is limited by the line-of sight distance which limits the direct transmission of quantum information to around few thousand kilometres. One solution to reach true global distances while relaxing the security assumptions used in satellite QC is to equip satellites with quantum memories (QMs). This would allow the implementation of satellite-based quantum repeater networks that could potentially cover global distances and increase the secret key rates by synchronising otherwise probabilistic detection events. On the other hand, scientifically, the possibility of observing gravitational effects on quantum systems has the promise of bringing new perspectives into the search of a quantum theory of gravitation. In this regard, research into long-lived entanglement of quantum matter systems in curved space time could yield new physical insights. Along these lines we propose to develop a space-compatible, small-footprint laser-cooled quantum memory with storage times in the order of seconds. Our preliminary work suggests that such a system could beat the memory-less quantum communication schemes with realistic memory performances.


**Keywords:** quantum memories, quantum communication, quantum key distribution, satellite based communication, quantum repeaters
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Quantum Topological Polaritonics'.

assistant: **Objectives**

The recently proposed idea of topological band classification in photonic crystals has led to the prediction and observation oftopologically nontrivial photonic phases, phenomenologically similar to Quantum Hall and Quantum Spin Hall electronicphases, and to the development of a new field in physics – topological photonics. Photons at the edges of topologicallynontrivial photonic crystals are protected from backscattering and can be used for unidirectional guiding of light, which isextremely promising for optical logical device applications and for future optical computers. These ideas have recently givena new dimension to the field of polaritonics, which is the semiconductor optics equivalent of cavity quantum electrodynamics,where bound electron-hole pairs, or excitons, are strongly coupled to cavity photons to give rise to interacting quasiparticles:polaritons. Topological polaritonic states were shown to emerge in nanostructured microcavities solely from polaritonrepulsive interactions and can be controlled by optical means, contrary to the purely photonic case. In contrast to electronicand photonic topological physics, quantum topological polaritonics combines strong nonlinear and non-Hermitian quantumeffects that remain to be explored. This project will provide the fundamental theory basis for quantum topologicalpolaritonics, a new emerging field that unites topological photonics with polaritonics. The applicant, in collaboration with thehost group, will develop the geometric theory and the topological classification of polaritonic states, accounting for theirstrongly nonlinear and non-Hermitian nature. He will also apply this theory to the experimentally studied polaritonic systemswith potential impact on optical devices of the future.


**Keywords:** Polaritons,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Building individual and community RESilience thrOugh NATurE-based therapies' (RESONATE), addressing dissemination and exploitation.

assistant: **Impact**

RESONATE will bring together a consortium of world leaders in Nature-based Therapy (NbT) research, practice, policy, and innovation with stakeholders in the health, environmental, economic, and societal sectors to: a) build a stronger causal evidence base of the links between nature, health, and well-being by demonstrating nature’s biopsychosocial resilience building capacities; b) demonstrate how multi-sectoral stakeholders can collaborate to implement locally acceptable and inclusive NbTs; c) increase awareness and acceptance of these benefits among the public, multi-sectoral stakeholders, and policy makers; and d) ensure wider utilisation of cost-effective NbTs, to help build more resilient individuals and communities in urban, rural, and coastal settings. This will be achieved through an on-line Global Systematic Map of existing NbTs, and nine Case Studies (CSs) using longitudinal cohorts, Randomised Controlled Trials, and a Community of Practice trial, spanning 8 countries, urban, rural, and coastal settings, and all three levels of the health promotion/disease prevention pyramid. CSs will collect sector-specific and process-related data spanning four sectors: health, environment, economy, and society. Outcomes will include effectiveness, mechanisms, equity (fairness/inclusivity), environmental sustainability, cost-effectiveness, and social acceptability. Selected CSs will develop Social Innovation Action “Nature-based Resilience Hubs” to demonstrate best practice cross-sectoral collaboration and market potential. Results will be synthesised to give insights into scaling-up/scaling-out potential, and summarised in a Toolbox of practical Guides and Tutorials aimed at different end-users, as well as an overall “What Works Nature-based Therapy Guide” for NbT implement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring the Urbanism of Roman Mediterranean Ports: from iconographic data to 3D reconstruction' in the context of a Horizon Europe call.

assistant: **Objectives**

Under the Roman Imperial period, Mediterranean port cities were not only transit hubs - where ships, people and goods both departed and arrived - but also places of urban and cultural life developing away from the seafront. They formed a real urban landscape with enough characteristics of complete cities whose aesthetic and monumental features were widely emphasised in iconography. Although these highly codified images are not snapshots of reality, previous doctoral research assessed the documentary value of iconographic evidence for understanding Roman portscapes by inevitably confronting them with archaeological and textual data. UrbaPort (Exploring the Urbanism of Roman Mediterranean Ports: from iconographic data to 3D reconstruction) is an interdisciplinary project that aims to understand the urban and architectural morphology of Roman maritime port cities and to propose reliable virtual reconstructions of these environments. To achieve this goal, UrbaPort will propose an innovative reflection that will consider how iconographic evidence could be integrated to the digital tools for expanding the scientific value of historical restitutions in order to replace maritime activities in their architectural context. UrbaPort will bring together an unprecedented combination of advanced computational methods – 3D modelling and smart generative methods – developed by the CNRS/MC MAP-Aria laboratory (Ecole Nationale Supérieure d’Architecture de Lyon) with the recent archaeological data conducted at Portus – the port of the Imperial Rome – by the Ecole française de Rome in the perspective of a virtual exhibition at the Archaeological Park of Ostia antica.


**Keywords:** Iconography, Architecture, Roman Mediterranean, Urbanism, 3D modelling, Tools of mediation, Roman art, Roman
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microbiome Abundance Profiling: Precision microbiome profiling for insights into human health & research' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The thousands of microbial species that compose the human gut microbiome are linked to diseases from cancer to diabetes, sparking tremendous interest among pharmaceutical/ medical researchers in microbiome analytics. Current analytics methods are far too slow, expensive, and inaccurate to fulfil this need. Much faster techniques are essential for microbiome tracking over the course of disease states and therapies to discover correlations with disease and enable personalized medicine. Perseus MAP is the only microbiome analytics platform that will be able to handle this onslaught of demand, through a revolutionarily fast, high-throughput, and accurate technology based on DNA imaging techniques invented in the lab of our co-founders. We will massively accelerate microbiomics, starting with a central service lab, deploying satellite labs, and finally producing portable units for the microbiomics mass market, at a capacity of 300k profiles/yr analyzed in-house to seize a 2.5B market.


**Keywords:** biomarkers,pattern matching,barcoding,Microbiome,super resolution microscopy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Numerical modeling of cardiac electrophysiology at the cellular scale' in the context of a Horizon Europe call.

assistant: **Objectives**

Cardiac function is coordinated by an electric system whose disorders are among the most frequent causes of death and disease.  Numerical models of this complex system are mature and widely used, but to match observations in aging and diseased hearts they need to move from a continuum approach to a representation of individual cells and their interconnections. This makes the problem more complex, harder to solve, and four orders of magnitude larger, necessitating exascale computers.The EuroHPC-2019 MICROCARD project is developing a simulation platform that can meet this challenge, by a joint effort of HPC experts, numerical scientists, biomedical engineers, and biomedical scientists, from academia and industry. Our proposal is to establish a Centre of Excellence that will consolidate and scale up the MICROCARD results enabling digital twins of cardiac tissue.With a consortium gathering the core partners of MICROCARD, we will further develop MICROCARD's numerical schemes, moving to second-order spatial discretization. Based on MICROCARD results, we will develop mixed-precision preconditioners and data compression to reduce communication bandwidth. The highly successful efforts towards automated compilation of high-level model descriptions into optimized, energy-efficient system code for different CPUs and GPUs will be extended to upcoming architectures. We will continue efforts to robustify parallel remeshing software and add necessary functionality for parallel mesh partitioning and production of realistic synthetic tissue meshes needed for simulations.The platform will be benchmarked with realistic test cases and be made accessible for a wide range of users with tailored workflows.The platform will be adaptable to similar biological systems such as nerves, and several