RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Document management and test procedure improvement' (DOCTES) under Fourth Framework.

assistant: **Objectives**

TEKNIKER as a Technological Research Centre develops a large amount of projects in different areas. The number and complexity of the projects generates problems in the generation and maintenance of the documentation. These projects should be tested in an efficient and rigorous mode. TEKNIKER is involved in a process of quality assurance following UNE-EN-ISO-9001 standard. The objectives of the project are the generation of new procedures that following UNE-EN-ISO-9001 control the document generation and management along the project life cycle and implement a full module testing and verification procedure.THE EXPERIMENTThe experiment will be focused in the Engineering and Support process categories of SPICE, the incoming ISO standard for software process assessments. The different procedures involved in software development will be analysed focusing in the information managed in these procedures and the way to disseminate along the development team the changes in documentation.The use of Lotus Notes for management and dissemination, and Easy Case for production of documents will be analysed.To fulfil the other objective of the project, the improvement of tests definition and production, an analysis of the conditions signalled by known methodologies like METRICA will be analysed and procedures and guides will be developed.The baseline project of the experiment is a Design To Cost system that will provide the designers of automotive part components, technical and economic information in order to improve the quality of products, as well as minimise the costs derived from redesign.TEKNIKER employs 85 people, 33 of them are involved in the production engineering department.EXPECTED IMPACT AND EXPERIENCETEKNIKER expects as a result of the experiment to improve the quality of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The World's first cost effective, electronically steerable, digital, low profile, phased array antenna to enable high speed satellite communications on the move' under Horizon 2020.

assistant: **Concept**

The demand for mobile communications is growing at  compound rate CAGR of 61% p.a. and forecast to do so beyond 2022. Global mobile data traffic grew 81 % in 2013 and reached 1.5 Exabyte’s per month at the end of 2013, up from 820 petabytes per month at the end of 2012. Users now demand fast and affordable connectivity when and wherever they are. The growing use/ownership of laptops, tablet computers and larger smart phones has also led to an increasing demand for high quality content such as HD video on the move. Current satellite communications antennas cannot fully meet this large and growing need: Mechanically steerable antennas which are bulky, heavy, require maintenance and pose considerable vehicle integration challenges. Phased arrays based on military technology are too costly for commercial applications. Existing low cost antennas trade-off the cost of the antenna against the requirement for much more expensive satellite bandwidth per Mbps transmitted. Their performance is also too limited for use in certain geographical areas (particularly at large skew angles).  The overall objective of this project therefore is to successfully refine and scale up for market readiness the world’s first cost effective, electronically steerable, digital, low profile phased antenna to enable high speed satellite communications on the move. This will enable us to gain a substantial market share in the € 1.185bn Broadband Satellite Communications-on-the-Move (COTM) market and the associated antenna market which amounts to €0.39bn. Both of which are growing rapidly. We predict that we can achieve a 2.5% market share by 2020, generating total revenues of €134m and a cumulative EBITDA of €63m, creating 781 jobs. Our prototype system technology is demonstrated and proven in a relevan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Endosignal'.

assistant: **Innovation**

Inflammatory bowel disease is a devastating disease affecting several million people in Europe. This proposal addresses the molecular mechanism of inflammatory bowel disease. The multi-PDZ domain protein FRMPD2 (FERM and PDZ domain containing protein 2) has been shown to be an integral part of the immune host defense of epithelial cells by recruiting NOD2 (Nucleotide-binding and oligomerization protein 2), a key player of the innate immune system, to the basolateral membrane in epithelial cells. In addition, FRMPD2 is involved in epithelial cell/cell adhesion regulating tight junction formation. Multi-PDZ domain proteins are scaffolding molecules assembling large protein complexes dedicated to signaling and membrane trafficking. Interaction of NOD2 with FRMPD2 places the NOD2 protein into a novel context being part of a larger protein complex. Using an interdisciplinary approach combining state of the art techniques from cell biology, protein chemistry, membrane physics and developmental genetics, this proposal aims at the identification and functional characterization of novel components of the FRMPD2 protein complex. In particular, this protein complex will be characterized with respect to mechanisms relevant to epithelial cell polarization and inflammatory bowel disease. Finally, the project aims to complement in vitro mechanistic and cell culture data with in vivo results by analyzing the role of the FRMPD2 complex in zebrafish development. Finally, using a Salmonella infection model, a zebrafish animal model for inflammatory bowel disease based on the FRMPD2 complex will be established. The results of this project will lead to a better molecular understanding of the disease opening potentially new avenues of treatments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An Edible Microelectrofluidic Biosensor for Gastric Enzyme Quantification' under Horizon Europe.

assistant: **Concept**

EDISENS will deliver the first edible microelectrofluidic biosensor for enzyme activity quantification in gastric fluid that the human body can digest after completing its task. This will be accomplished by integrating passive microfluidics, electronics, and bioreagents into an edible device fabricated with food-grade materials. The biosensor will find application in the detection of pancreatic diseases, including pancreatic cancer. Today, existing ingestible electronics represent a trillion-dollar market. Yet, they suffer from retention risk as they use non-degradable materials and heavily contribute to the accumulation of e-waste in the environment. EDISENS will deliver a safe-to-eat device performing a rapid accurate enzymatic test on gastric fluid before being digested that eliminates the retention risk and does not require hospitalisation and disposal. The proposed technology will be highly versatile and will be beneficial for applications beyond our immediate test case. The transition to edible alternatives will spark the next generation of diagnostic devices for gastrointestinal tract monitoring which are safer, non-invasive, environment friendly and can be used at the point of care. The project will start a change in the social perception of diagnostic devices, where safe and familiar materials can be engineered to provide non-invasive diagnostic tools: EDISENS works toward the vision that clinical testing will be as easy as eating candy one day. This action is in line with the Horizon Europe global challenges program that promotes advanced non-invasive safer health technologies and a greener and more sustainable European society. For the success of this action, the researcher will utilise his experience in standard point-of-care and ingestible electronics, expl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Analyse et conception optimale non-deterministes des systemes des structures et des procedes' (ANACONDAS2).

assistant: **Innovation**

In order to calculate the answer's statistical distributions, a new approach is being explored. The first phase of this project aims at refining the mathematical and computational underpinnings of this approach.Industrial companies are increasingly interested in the non-deterministic aspects of systems, structures and processes design, and how uncertainty should be taken into account when dealing with optimisation issues, in the analysis and non-deterministic optimisation possibilities.The main difficulties of the stochastic methods lies in the evaluation of the answer's statistical distributions, with methods whose computational costs become prohibitive as the number of parameters increases or the expected confidence levels are high (Monte-Carlo Methods) or methods whose hypotheses are too restrictive (Stochastic finite Element Methods).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multi-omics characterization of descending motor circuits in the brainstem' (ReticulOme), addressing dissemination and exploitation.

assistant: **Impact**

The execution of coordinated and adaptive movements is the final manifestation of virtually all brain processes. Altered motor function is hence an associate feature of almost all conditions that affect the nervous system and is highly debilitating. This program will shed new light on the neuronal basis of movements with a focus on the cooperative roles of the brain and the spinal cord for composing and orchestrating multifaceted and adaptive motor behaviors. Reticulospinal (RS) neurons of the brainstem reticular formation (RF) are pivotal for controlling the most vital movements. They have long been seen as a unified relay of command signals from various integrative centers upstream, to most, if not all, executory motor circuits downstream. Yet, based on recent findings and our ongoing work, we posit that RS neurons rather exhibit a substantial diversity and specialization by inputs and outputs that may support a form of selection and mixing of unitary components of composite motor behaviors. Imprinting from the advent of multi-omics strategies in the mouse model, we will intersect functional connectomics and single-cell gene expression (the transcriptome) to achieve a most comprehensive characterization of RS neurons diversity, specialization, and interactions with their upstream and downstream brain areas. We will first investigate the anatomo-functional organization of an already circumscribed subset of RS neurons for orchestrating orienting motor actions. We will in parallel investigate the role and connectivity of other RS neurons, and provide genetic hallmarks of new functionally-relevant subsets. Our results will propel forward our understanding of the complex organization of the RF, its role in orchestrating composite movements, and its links with the rest of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High Performance Light Water Reactor - Phase 2' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The overall objective of the HPLWR Phase 2 project is to assess the critical scientific issues and the technical feasibility of the High Performance Light Water Reactor (HPLWR) system with a view to determine its future potential. To accomplish this objective, a highly qualified team of seven research centres from seven different countries, two universities and an industrial partner will substantiate the concepts and ideas from the previous HPLWR research project.The measurable results of this project can be summarized as follows:- Conceptual layouts of the plant including core, reactor pressure vessel (RPV) components and balance-of-plant - refined economic assessment- analysis of the thermal core for neutronic, thermalhydraulic and mechanical aspects - decision on the feasibility of the fast core option- concept of safety system which leads to fulfil the European Utility Requirements and assessment of the safety system by simulations of several accidents and transients with improved safety codes- selection of tested materials and data for fuel rod cladding, core and RPV materials and specifications for the water chemistry- numerical heat transfer modelling and derived correlations- evaluation of the concept on its environmental impact, resource utilisation and proliferation resistance- European research agenda and industrial deployment strategy.The assessment criteria are provided by the European Utility Requirements and the technology goals of the Generation IV International Forum. In both time frame and content, the project fits perfectly into the Generation IV roadmap, and is complementary to the international research on Supercritical Water Cooled Reactors (SCWR). A training and educational program is carried out in course of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Research of bis-specific inhibitors of telomerase - development of combinatorial synthesis and high throughput screening of oligonucleotide -peptide libraries' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Research objectives and content  Telomeres are the repeated sequences of DNA, and associated protein, that occur at the 3' ends of eukaryotic chromosomes. They are synthesized by specialized DNA polymerase, telomerase, a ribonucleoprotein enzyme that uses an in-built RNA template. Current data link the activity of the enzyme telomerase to several forms of cancer. Specific inhibitors of telomerase are now needed to directly test this relationship, help understand the mechanism of telomerases and serve as lead compounds for potential future anti-cancer agents. The RNA-template portion of telomerase has been shown to be a target for antisense oligonucleotides. We aim to enhance the binding interaction substantially by the addition of a second binding interaction and propose to generate molecules bearing antisense component (DNA or peptide nucleic acids) directed at the RNA template of telomerase and also a pendent oligopeptide component to target the anchor site of telomerase.Since there is no structural information available on this second anchor site, we propose to employ combinatorial synthesis to identify lead compounds for telomerase inhibition. Combinatorial synthetic methodology will be developed to prepare libraries peptides conjugated to antisense DNA or PNA sequences. The DNA-peptide and PNA-peptide libraries will be screened to select potent telomerase inhibitors that will be characterised by quantitative biochemical and biophysical methods.  Training content (objective, benefit and expected impact) My interest is to acquire during my postdoctoral position fresh knowledge ininnovatory field of combinatorial chemistry (synthesis and screening). The present project offers me also the opportunity to complete my scientific skills in oligonucleotide and peptide chemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Mass Market E-commerce Services Using Multi-language Natural Spoken Dialogues'.

assistant: **Innovation**

The project is researching methods to extend the spoken human language technology capabilities of advanced mass market e-commerce services beyond their current capabilities for information provision into transactional services which are revenue generating and into customisable services where citizens can tailor the user interface to their own requirements.Working in German, English and Italian, customisable e-commerce services are being developed for the financial services and travel industries.The project is also addressing the specification of interface protocols and API drivers for interfaces between spoken HLT and HML Web resources such as enterprise databases.Objectives:The objectives of the project are to create advanced spoken HLT user interfaces which offer transactional and customisable user interfaces for mass market telephone-based consumer applications in the financial services industry and in the travel industry in Germany, UK and Italy. The work will extend to definition of interface standards for mass market to internet (HTML) data via spoken HLT systems.Milestones:The milestones of the project include creation of a spoken HLT demonstrator and Design Guide, Case Studies and a group of reference sites throughout Europe where other European companies will be welcomed to view the power of advanced spoken HLT technology and to learn how it can benefit their own enterprises. These aspects of the project will serve as key contributions to the concertation efforts of the IST Programme.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Innovation Policy in a Shifting International Context: Theoretical Analysis and Empirical Assessment' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and contentDYNAMIC CONSIDERATIONS: Imposing constraints on the negative externalities of production or consumption may help spur Technological Development. Technological Development, in turn, has consequences for Growth. The latter effect is the object of Endogenous Growth Theory. I propose to study the effect of environmental policy on the Endogenous Growth process. We can consider sustainable development as an endogenous growth process. Different kinds of constraints on polluting activities elicit different responces, in terms of the degree and direction of Technological Development. I propose to formalise these effects and estimate them empirically. Furthermore, other important issues are involved: Will a given, common environmental policy cause the same growth response throughout the E.U? Is it conducive towards the convergence process, or does it jeopardise it? How can it be expected to affect employment? These issues should be studied empirically. Training content (objective, benefit and expected impact) CentER's expertise in panel modelling of structural dynamic systems (Research Theme IV), and in Industry simulation modelling (Research Theme V) will be a strong support for my research. Pr. Rustichini's work on evolutionary theory and the development and diffusion of technological change Pr. de Zeeuw's work on international competitiveness, technology and strategic behaviour and Pr. van der Ploeg's study of cross-border pollution as a differential game will help extend the lines of research I have pursued. CentER's intense consulting activity will help enrich my research with fresh insights and orient my empirical work in an operational manner. SPRU (U of Sussex), BETA (U of Strasbourg) and other European centres on Technological Innovation ro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cloning and functional analysis of fish peroxisome proliferator-activated receptors: the transcriptional control of lipid metabolism in farmed fish species' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

OBJECTIVES AND EXPECTED ACHIEVEMENTSThe aim of this proposal is the acquisition of the appropriate molecular and cellular tools that will enable to address the issues of the increased lipid deposition in the tissues of farmed fish and the apparent dietary requirement of many of the farmed fish species for n-3 polyunsaturated fatty acids.Both of these issues are of primary concern for the modem intensive aquaculture industry. To this end, it is proposed to study the function and mode of action of the Peroxisome Proliferator-Activated Receptors (PPARs) in fish. PPARs are a class of ligand activated transducer proteins belonging to the nuclear hormone receptor (NHR) superfamily. PPARs are recognised as key regulators of both arms of lipid homeostasis, i.e. fatty acid oxidation (catabolism) and triglyceride accumulation (adipogenesis), in higher vertebrates. Ligands for the mammalian and amphibian PPARs have been identified and they include natural fatty acids.