RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Single-cell dynamics of Gal1 transcriptional memory inheritance in Saccharomyces cerevisiae' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Transcriptional memory offers a mechanism for adaptive response to various types of repeated stimuli. Thus far the mechanisms that govern transcriptional memory are poorly understood, although evidence of its heritability to progeny suggests that they rely on epigenetic cues mediated through chromatin. Furthermore the dynamics of transcriptional memory at the single-cell level are not known, which is key to understanding the regulation of transcriptional dynamics and environmental adaptation. This proposal aims to unravel the mechanisms of transcriptional memory by studying a simple memory model, the inducible galactokinase 1 (Gal1) gene in Saccharomyces cerevisiae. In particular, I will address transcriptional memory at the level of the individual cell and the molecular mechanisms underlying “epigenetic” memory.  I will use state-of-the-art live-cell timelapse imaging, microfluidics, and pedigree mapping to study single-cell dynamics of the inheritance of transcriptional memory in yeast cells through division. To elucidate the mechanisms by which transcriptional memory is regulated, I will screen a mutant library for chromatin factors that are potentially implicated in transcriptional memory. By combining these techniques with classic chromatin biochemistry I will unravel the function of the regulators of transcriptional memory. Finally I will establish the biological impact of transcriptional memory by determining whether this memory imparts an advantage on cell survival. Because “epigenetic” mechanisms are highly conserved, my studies will reveal fundamental mechanisms by which memory is maintained within a cell and inherited from an individual cell to its progeny in eukaryotes. This knowledge is essential to understand how cells integrate responses to repeated envir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Supporting EU-African Cooperation on Research Infrastructures for Food Security and Greenhouse Gas Observations' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

African societies face growing global change risks, with rapidly changing patterns of human settlements and intensity of use of ecosystem services. At the same time, climate variability and climate change trends are intensifying stress on the ecosystems that ensure environmental security, both locally (e.g. ecosystem services), regionally (e.g. sustainable development options) and internationally (e.g. carbon sequestration). Approaches that can address this challenge in an integrated and multidisciplinary way are urgently needed in many places in Africa where there is a close relationship between societal well-being and environmental condition, relating particularly to biomass for energy and food production, and hydrological considerations such as water yields. Policymakers and land-use decision makers are increasingly dependent on knowledge on the state of the environment. Long-term observational systems and research infrastructures have been identified to be indispensable elements of knowledge generation to serve climate change adaptation, food security, and climate change mitigation.This proposal supports EU-African cooperation on research infrastructures. Its aims are to increase coherence and interoperability between infrastructures in Europe and Africa, to enhance technical competence, science awareness and life-long learning in Africa in order to facilitate the use of research results for evidence-based policy making, and to identify knowledge gaps for future research directions. The project will1) identify the essential parameters needed to develop science based strategies to improve food and nutrition security including early warning systems and to mitigate climate change,2) formulate a roadmap towards fully interoperable and accessible research infrastructures
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In Vivo CRISPR-Based Nanoplatform for Gene Editing:  A New Disruptive Avenue for Non-Invasive Treatment of Genetic Brain Diseases' under Horizon Europe.

assistant: **Concept**

Genetic brain diseases are among the most devastating and fatal diseases, typically having only palliative treatments and no cure. The revolutionary CRISPR/Cas gene editing technology provides a new horizon and enormous potential for treating such diseases. However, efficient and safe delivery of CRISPR machinery to diseased cells within the brain is one of the greatest challenges in medicine today. Here, I plan to expand far beyond the state-of-the-art, and propose a game-changer approach for this unmet need: A breakthrough nanoplatform, which will transform CRISPR into a clinically-relevant, non-invasive technology, enabling therapeutic genome editing in the brain. Our proof-of-concept results serve as the baseline of this pioneering research project, revealing the exceptional capabilities of insulin as a key to overcoming formidable brain and cell barriers. We will harness these unique abilities within the novel nanoplatform, and shuttle CRISPR machinery across the blood-brain barrier, transport it into deep brain regions, and mediate its successful entry into specific diseased brain cells, leading to highly effective gene editing. The nanoplatform will be designed to meet key criteria for non-invasive, safe and efficient delivery of CRISPR to the brain, while conferring a high degree of modularity and compositional heterogeneity - thus providing both universal and patient-specific components. The nanoplatform will be thoroughly investigated in primary brain cells, 3D organoids, and case-studies of monogenic brain disease models. This comprehensive research will culminate with a universal and modular BrainCRISPR nanoplatform, and delineate design principles for its precise tailoring to specific needs of different brain diseases. Overall, this research will provide in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A novel approach to non-invasive and personalized skin cancer diagnosis' under Horizon 2020.

assistant: **Concept**

French SME-company DAMAE Medical is facing skin cancer worldwide issue by developing the OCTAV Project, a new approach todermatological diagnostic based on a disruptive Line-field Confocal Optical Coherence Tomography (LC-OCT) technology, in a novelhand-held imaging device.OCTAV is designed to capture in situ images of the skin layers with a cellular resolution. It is used in conjunction with dermoscopy toprovide more accurate diagnosis, leading to fewer biopsies of benign lesions and earlier detection of melanoma (clinical use 1) andnon-melanoma skin cancers (clinical use 2). It may also guide the surgery to provide more accurate presurgical margins (clinical use3), preventing unnecessarily large scars and reducing the risk of recurrence.Correlatively, DAMAE is developing a full software solution, based on a data storage cloud-platform, a computer-aided softwaredesigned to assist dermatologists with OCTAV image interpretation, as well as telepathology and patient services.OCTAV device will initially be used by clinicians as a routine easy-handling diagnostic device in public practices (market segment 1).Implementation of OCTAV software will enable its adoption by a much larger market, consisting of private practices dermatologists(market segment 2). The approach will contribute to the development of skin cancer risk patient awareness, while changing thecurrent paradigm through a timely, performant, and non-invasive approach, and releasing the financial burden on the healthcaresystem.Project OCTAV has successfully completed in 2017 a feasibility phase covered by the SME Instrument Phase 1, resulting in a TRL6prototype of the technology and a first consolidated atlas of skin cancer clinical images. The main objective of this Phase2 is toscaleupthe OCTAV solution to TRL9
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'HETeRoaromatic biomolecules Ultrafast Spectroscopy in liQuids' (HETRUSQ).

assistant: **Concept**

I propose to determine the complete ""structure-dynamics-function"" picture of the photoinduced processes happening in heteroaromatic bimolecules in solution under ultraviolet (UV) light exposure.Whilst light induced processes are essential to life (vision and light harvesting processes such as photosynthesis are two prominent examples), they can also be extremely detrimental, as is the case for UV radiation damage of DNA. Nucleobases readily absorb UV light, accessing an electronically excited state and potentially triggering a structural rearrangement, leading to photolesions. Still, these “building blocks” of life present an inherent resistance (""photostability"") to these processes, compared to other classes of molecules. This property, far from being comprehensively understood, is believed to be linked with how efficiently these molecules release the excess energy of the photo-prepared electronically excited state through non-radiative relaxation pathways (conical intersections - CIs).The location and topography of CIs can be extremely environment-dependent, particularly in a polar solvent like water: it is thus the interplay between solute and solvent that governs the dynamics and, thus, biological function of these molecules.I propose to perform few-fs resolved deep ultraviolet (DUV) pump - extreme ultraviolet (XUV) probe time resolved photoelectron spectroscopy (TRPES) studies on heteroaromatic biomolecules in solution, with the goal of determining their solvent dependent structural changes (location of the relevant CIs) and the early stages (first tens of fs) of the related ultrafast relaxation pathways.A deeper understanding of the relationship between the structure, dynamics and function of heteroaromatic biomolecules in solution under UV exposure could have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding the Role of Diversity in European Research' (URDER).

assistant: **Innovation**

The recent intensive sociopolitical debates on racism and the colonialism, which created a wave of protests across the Global North, has broken the ordinariness of the racial status quo endemic to the modern social institutions. In academia, it has enforced a series of initiatives, asking for reconsidering curricula and diversity quotas. The URDER project takes a step back from these societal debates to understand how practices of diversity are understood and applied by those who have a central impact on academic knowledge production and science more generally: the reviewers of academic grants. By studying the evaluation practices of the review panelists of the European Research Commission grant awards, the project will explore how scientific excellence is linked with diversity practices in the European research space. Bringing together (a) science policy studies, (b) cultural sociology, and (c) postcolonial critique, the URDER project seeks to investigate how the European academic elites in social sciences and humanities understand the role of decolonial, anti-racist, and diversity initiatives in European research. The proposed project will allow for training the Fellow in science policy, research management, and research evaluation while the Fellow will offer her valuable knowledge in postcolonial theories, feminist epistemology, and intersectionality. To provide conceptual overlaps between these fields of research will allow for critical assessment of diversity initiatives and propose effective solutions to address diversity in academia.


**Keywords:** Decolonization, diversity, sociology of academic work, cultural sociology, postcolonial theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Spatio-TEmporal Linked data tools for the AgRi-food data space'.

assistant: **Innovation**

STELAR will design, develop, evaluate, and showcase an innovative Knowledge Lake Management System (KLMS) to support and facilitate a holistic approach for FAIR (Findable, Accessible, Interoperable, Reusable) and AI-ready (high-quality, reliably labeled) data. The STELAR KLMS will allow to (semi-)automatically turn a raw data lake into a knowledge lake. This is achieved by (1) enhancing the data lake with a knowledge layer, and (2) developing and integrating a set of data management tools and workflows. The knowledge layer will comprise: (a) a data catalog offering automatically enhanced metadata for the raw data assets in the lake, and (b) a knowledge graph that semantically describes and interlinks these data assets using suitable domain ontologies and vocabularies. The provided tools and workflows will offer novel functionalities for: (a) data discovery and quality management; (b) data linking and alignment; and (c) data annotation and synthetic data generation. The KLMS will combine both human-in-the-loop and automatic approaches, to leverage background knowledge of domain experts while minimizing their involvement. To reduce manual effort and time, it will increase the automation of finding and selecting relevant data sources, configuring, and tuning the involved data management tools, and designing, executing, and monitoring end-to-end data processing workflows adapted to different user needs. The KLMS will include specialized tools and functions for geospatial, temporal, and textual data. An organization, ranging from a data-intensive SME to the operator of a data marketplace, will be able to use the STELAR KLMS to increase the readiness of its data assets for use in AI applications and for being shared and exchanged within a common data space. The STELAR KLMS wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A cell separation microfabricated platform for cell migration and invasion assays' (TOPOCELL).

assistant: **Concept**

Cell migration is essential for tissue development, homeostasis, tumor progression, including the responses to wounds and inflammation. Cell interactions with their microenvironment affect many cellular functions such as spreading, migration and even differentiation. These interactions can be studied by incorporating micro- and nanotechnology-related tools. The design of substrates based on these technologies offers new possibilities to probe the cellular responses to changes in their physical environment. The investigations of the physical interactions of cells and their surrounding matrix can be carried out in well-defined and near physiological conditions. In tissues, cells encounter confined environments and narrow spaces that could favor or prevent migration. In the DURACELL ERC project, we are studying the impact of substrate stiffness on cell migration. We propose to develop and use microfabricated substrates to control substrate confinement and topography and thus analyze cellular responses. Such elastomeric substrates are designed that contain ordered micron-sized pillars allowing cells to transmigrate through versatile confined spaces. The development of accurate methods to study cellular transmigration is important to answer fundamental biological processes and for cell-based therapy and drug screening. The well-accepted methods for transmigration assays including Boyden chambers, microfluidic devices present important limitations including spatial and temporal resolutions, limited variability and control of porosity composition and geometry. To overcome these limitations, the goal of TRANSCELL is to develop in-plane micropillar substrates whose geometry can be easily tuned to control and analyze cell transmigration, cell sorting and ultimately genetic expres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Motion of Tracers in random Environments and the Einstein relation' to be submitted under Sixth Framework.

assistant: **Abstract**

We are interested in the study of the motion of tracer particles in random environments, realised either by random fields or by interacting particle systems with stochastic dynamics. When a tracer particle, initially performing a diffusive motion, is submitted to a uniform external field it starts drifting and reaches an asymptotic velocity. The Einstein Relation suggests that in the limit as the external field vanishes the velocity becomes proportional to the field, the constant of proportionality being the self-diffusivity of the tracer. Such a relation is believed to be generally valid for time reversible systems.Until recently, rigorous proofs existed only for very few models and were in general ad-hoc. During the last two years however, tools are being developed that aim towards a unifying approach. We propose to study some open problems related to specific models (simple exclusion processes, divergence-free random fields) and work towards a general proof of the Einstein Relation with only mild assumptions on the system other than time reversibility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High above the ocean: unexplored molecular processes' (HAVEN).

assistant: **Innovation**

Oceans cover more than 70% of the Earth's surface and generate particles in the atmosphere that are viewed as a core component of the climate system, especially due to their role in marine cloud formation and the strong control they have on their ability to reflect sunlight to space. With our recent findings, we have made great progress in documenting the formation of new particles by nucleation of low volatile gas-phase species in the lowest altitudes of the open ocean atmosphere and its relation to water biogeochemistry. Nucleation is however expected to be promoted at higher altitudes, in the marine free troposphere (MFT), and the entrainment of growing particles formed in the MFT is further suspected to be a major source of low-level marine cloud forming particles. Yet, because of limited observations, very little is known about MFT nucleation, which contributes to major uncertainties both in the assessment of present-day radiative forcing associated to aerosol-cloud interactions and in future climate projections.The main purpose of this project is to identify the species driving MFT nucleation and evaluate the impact of the process on cloud condensation nuclei (CCN) number concentration, and ultimately on marine cloud formation and properties. To achieve this goal, we will first use an innovative experimental setup consisting of a nucleation chamber filled with natural free tropospheric air coupled to state of the art instruments to identify the nature of the nucleating species. Experiments will be performed on Reunion Island, in the southern Indian Ocean, which is particularly sensitive to natural aerosol sources. These measurements will in a second step be used to initiate a modelling study that will further complement the observations, allowing first to evaluate