RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Research project on high field nmr and molecular. Dynamics study of interaction between dna and modified hoechst 33258' (1994-1998).

assistant: **Innovation**

Double stranded DNA, the carrier of genetic information, is an ideal target for the treatment of cancer and viral desease. Inhibited gene expression by creating irreversible damages on DNA is now a widely use strategy. Various nuclease chemical systems are described in literature. For example, mesotetrakis(4-N-methyl-pyridiniumyl)porphyrinato-Mn(m) is an efficient DNA cleaver[1]. We will focus our interest on modified Hoechst 33258 coupled to a metalloporphyrin[2] or on catecholate analogues of Hoechst 33258 able to chelate copper (II)[3]. In order to optimize nuclease activity of such system, investigation of interaction between these molecules and DNA is necessary. Training content (objective, benefit and expected irnpact) The project will involve modelling to rationnalise potential binding models of the hybrid H33258 to duplex DNA and some high field NMR studies of the complex. It may also involve fluorescence titration of the complex (including stopped-flow). I shall also be able to interact with Pr Douglas on his new DNA cleavage system, thus transferring expertise from our Toulouse laboratory. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'X-ray crystallographic studies of the n-terminal domain of a stat protein' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Reseach objectives and content  The STAT proteins (Signal Transducers and Activators of Transcription) are a recently discovered class of eukaryotic transcription factors regulating the expression of genes activated in response to cytokines and growth factors. The goal of this research project is to determine the crystal structure of the 16 kDa N-terminal domain of a STAT protein. This domain mediates the cooperativity between STAT dimers bound to tandem DNA target sites. The objectives of the first year are to express, purify and crystallize the N-terminal domain, while those of the second year are to solve the structure by X-ray crystallography. A crystal structure will provide insight into how cooperativity is achieved and will facilitate the design of biochemical and mutagenesis experiments aimed at probing the function of this domain. Training content (objective, benefit and expected impact)  This project will provide training in basic molecular biology and biochemistry techniques, particularly those that relate to protein expression and purification. These skills will make me a more versatile structural biologist, and in the future will permit me to undertake a wide range of structure determination projects, including those which begin with a DNA fragment encoding the protein of interest. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The next-generation planet formation model' (PLANETESYS) targeting Horizon 2020.

assistant: **Abstract**

The goal of this ERC Consolidator Grant proposal is to make significant contributions to our understanding of the formation of planetary systems and the chemical composition of planets. I will achieve this by developing a planet formation model that integrates the most relevant physical processes and combines the newly discovered pebble accretion mechanism with gravitational interaction between a high number of growing embryos. Exploiting the results of the computer simulations will allow me to address three major, outstanding research questions in the study of planets and their formation:* What are the dominant physical processes that shape planetary systems?* How are solids flash-heated in protoplanetary discs?* What are the conditions for forming habitable planets?I will follow the chemical composition of solid bodies in a protoplanetary disc as they grow from dust grains to fully fledged planets. This will shed light on the formation pathways of all major planetary classes – from terrestrial planets, over super-Earths to ice giants and gas giants – in orbital configurations acquired under the combined effects of planetary growth, migration and gravitational interaction between the developing planets. I will examine the role of the CO iceline as a nursery for planetary embryos that grow and migrate to form cold gas giants akin to Jupiter and Saturn in our Solar System. I will also explore the formation of the mysterious chondrules – widespread in primitive meteorites – by lightning discharge during planetesimal formation and address the role of chondrules for planet formation. Finally, I will simulate the delivery of life-essential volatiles to terrestrial planets and super-Earths in the habitable zone, considering the simultaneous growth of rocky and icy planetary e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Information in functional optical coherence tomography and microscopy' (INFO-FOCT) under Sixth Framework.

assistant: **Objectives**

The full potential of coherent-gated functional imaging capabilities in scattering media has not been yet realized. Particularly, optical coherence tomography and microscopy (OCT) present a promising investigational tool in cellular biology, especially when combined with principles of Information Theory for analysing the measured functional OCT (fOCT) signal. This research aims to explore the dynamic non-linear response of tissues and cells excited by an optical pump signal by means of optical coherence imaging and spectroscopy. Sophisticated path-length and transverse-direction-resolved studies of measures such as water absorption and polarization states of reflected light will be conducted.A theoretical analysis will be directed towards:(i) deriving the Volterra kernels associated with the non-linear response of the biological medium as well as performing importance sampling Monte-Carlo light-tissue simulations in order to understand the relationship between the medium properties and the measured fOCT signal;(ii) the use of Shannon and Fisher information quantities to determine the information amount conveyed by the fOCT signal.The research results not only will set the theory of the inverse problem in fOCT on a firmer foundation, but also will significantly affect the safety and optimisation of the optical feedback control of therapeutic lasers, for instance in laser ablation procedures. This interdisciplinary proposal brings together Prof. Brett Bouma's group at Harvard Medical School and Prof. Theo Lasser 's group at the EPFLausanne, to combine their extensive expertise on OCT and microscopy with the objectives of adding scientific and complimentary competencies to the career of the applicant, Alberto Bilenca, extending his international research experience and pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A novel support material for 3D bioprinting and post-printing tissue growth: Print and Grow' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Three-dimensional (3D) bioprinting holds great promise for tissue engineering, with extrusion bioprinting in suspended hydrogels becoming the leading bioprinting technique in recent years. In this method, living cells are incorporated within bioinks, extruded layer by layer into a granular support material and undergo gelation through diverse cross-linking mechanisms. It offers high fidelity and precise fabrication of complex structures based on the living tissue properties, however the transition of cell mass mixed with the bioink into functional native-like tissue requires post-printing cultivation in vitro. An often-overlooked drawback of 3D bioprinting is the non-uniform shrinkage and deformation of printed constructs during the post-printing tissue maturation period. This leads to highly-variable and unpredictable engineered constructs, posing a challenge for the technology to meet applicative requirements.  We propose to develop a novel technology of ""Print and Grow"", 3D bioprinting into a specially designed microgel aimed to enhance the long-term structural stability of the printed objects by providing structural support and a possibility for live monitoring during tissue maturation. Our preliminary testing of the Print and Grow method demonstrated accurate bioprinting with high tissue viability while preserving the construct shape and size, unlike current state of the art approaches. We aim to optimize the support material properties and develop scalable and reproducible fabrication techniques. We also plan to test the Print and Grow for a wide range of tissue types and adjust the microgel according to specific tissue requirements. Finally, we will study the in vivo transplantation possibility of the tissue generated through the Print and Grow process. The res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Metabolic regulation of  metastatic growth' under Horizon 2020.

assistant: **Concept**

Metastatic growth of cancer cells requires extracellular matrix (ECM) production. The current understanding is that transcription factors regulate ECM production and thus metastatic growth by increasing the expression of collagen prolyl 4-hydroxylase (CP4H). In contrast, we recently discovered that metabolism regulates CP4H activity independently of the known transcription factors. Specifically, we found that loss of pyruvate metabolism inhibits CP4H activity and consequently ECM–dependent breast cancer cell growth. Based on this discovery we propose the novel concept that metabolism regulates metastatic growth by increasing ECM production. In this project we will investigate the following questions: 1) What is the mechanism by which pyruvate regulates CP4H activity in breast cancer cells? To address this question we will investigate pyruvate metabolism and ECM production in 3D cultures of various breast cancer cell lines using 13C tracer analysis, metabolomics, and two-photon microscopy based ECM visualization. 2) How can this novel metabolic regulation be exploited to inhibit breast cancer-derived lung metastases growth? To address this question we will inhibit pyruvate metabolism in metastatic breast cancer mouse models using genetically modified cells and small molecules in combination with immuno- and chemotherapy. 3) How can this novel regulation be translated to different metastatic sites and cancers of different origin? To address this question we will determine the in vivo metabolism of breast cancer-, lung cancer-, and melanoma-derived liver and lung metastases (using metabolomics and 13C tracer analysis), and link it to ECM production (using two-photon microscopy based ECM visualization). With this project we will deliver a novel concept by which metabolism r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development and corroboration of a novel Natural Textile Reinforced Mortar System for masonry retrofitting' (NaTeRM).

assistant: **Innovation**

Effective structural upgrading solutions are becoming increasingly important in Europe, due to the ageing building stock and the need for preserving heritage buildings. When the reinforcement of existing and historic masonry structures is faced, several challenges with respect to the compatibility, cost-efficiency and environmental impact of the methods used need to be answered. Project NaTeRM promises a breakthrough in realizing sustainable retrofitting solutions via the development of a novel externally bonded masonry reinforcement system comprising of plant fibre textiles embedded in inorganic lime-based matrix. This Natural Textile Reinforced Mortar (NTRM) will offer several advantages compared to analogous systems that incorporate synthetic fabrics. Natural fibres are bio-renewable, bio-degradable and have good economic feasibility. They also offer a higher degree of flexibility that precludes over-stiffening effects, enabling better mechanical behaviour when applied on weak masonry. The plant fibres used in this study will receive a natural hydrophobic treatment that will ensure adequate durability. The design of a vapour permeable lime matrix will guarantee compatibility with a wide range of masonry substrates, including porous and salt-laden surfaces. The planned research activities include experimental work for the production and characterization of the matrix material and of the composite, pilot applications on full-scale walls and computational studies for validating operational performance and for developing analysis tools for the proposed applications. The project goes several steps beyond the state-of-the-art which still lacks systematic investigations, design guidelines and real-scale applications of NTRM. The outcomes obtained will assist towards enhanci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Promotion of an Integrated European the National R&D Initiative for Fossil Enegy Technologies Towards Zero Emission Power Plant' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

For Europe to meet its future energy needs and to attain its environmental targets, whilst maintaining security of supply, a carbon management strategy needs to be adopted that embraces the use of fossil fuels alongside energy from other sources and a strong improvement in energy efficiency. For fossil fuels, especially gas and solids, this must entail the mitigation of CO2 through increased efficiency and the development of technologies that will lead to very low or zero emissions, including the use of CO2 capture and storage. The improvement of the performance of the key components, implementing new power plant concepts and sequestering carbon dioxide is substantial in this respect. FENCO is the preparatory step to form a single major European initiative for energy technologies towards a carbon free power production based on fossil fuels. It is foreseen to establish a European Research Area Network (ERA-NET) that defines a technology path towards low and near zero emission power plants on an extended European level and which links the R&D and demonstration needs of EU member states, the EU, industry and academia. It is envisaged that this will be based on a step-by-step approach combined with significant advances to ensure that future technologies will lead to an improved competitiveness through affordable energy prices whilst at the same time making a significant contribution towards attaining emission reduction targets. Within this SSA it is the aim of the mentioned Member States to prepare the structure and management processes of the following ERA-NET. This will be achieved by analysing the various research programs and academic initiatives in Europe, considering their position in a global sense, identifying synergies of approach and content and thus establishing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'VALIDATION OF THE MICROGAP CHAMBER TECHNOLOGY FOR DIGITAL RADIOGRAPHY, SPECIFICALLY MAMMOGRAPHY APPLICATIONS' (MICADO) under Fourth Framework.

assistant: **Objectives**

The Microgap Chamber (MCG) is a new type of high resolution position-sensitive detector for ionising particles. It relies on the principles of proportional gas counters but can be manufactured using microelectronics technology. The MGC was developed for the next generation of high energy, high rate particle accelerators at CERN. As a result of these efforts a device with interesting characteristics was obtained. The adaptation/transformation of the present MGC-detector to the capabilities required for the medical experiments was a joint development of IMEC, the University of Brussels, INFN-Pisa and the Weizmann Institute of Science.The project was aimed at the validation of gas electron multiplier technology within the area of digital radiation imaging systems. Specifically the project focused on the development of new real-time digital radiography detectors, combining Microgap Chamber Technology with a blue light photocathode capable of operation in a gaseous environment. The project addressed the present need of replacing photographic films or phosphor screens, by reliable, digital imaging devices in medical applications. It fitted within the new approach of bringing medical files in a centralised hospital information system.The new instrument will allow more efficient mammography with possible dose reduction, high throughput, high resolution, digital storage and on-line inspection capabilities. The specifications for this medical validation study and the system integration were undertaken by Agfa-Gevaert.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Acceleration of www adoption and effective use by European private and public sector' to be submitted under Fourth Framework.

assistant: **Abstract**

Supporting the Information Society, the goal of the W3UserNet project is to speed up adoption, by European businesses and organisations, of the tools and techniques that will allow them to seize the multiple opportunities offered by the World Wide Web. Focusing on users aspects, and complementing existing initiatives which concentrate on the technology, the W3UserNet aims at helping European companies, especially SMEs, to integrate the use of the Web in their business processes.Co-ordinated by a steering committee fully experienced in the Web environment, the W3UserNet network of members will be built from an initial base of users companies, focusing on SMEs and their business requirements. This will be facilitated by the presence of real SMEs as well as representative organisations of SMEs and users in the period steering committee. Then, as the project evolves, the W3UserNet will be expanded, welcoming many more companies who want to participate directly in the development and effective use of what is surely going to become an essential tool for maintaining and expanding their activities.The W3UserNet will undertake the following activities:- create and develop the W3UserNet,- collect and consolidate the requirements of the users for specific activity segments,- influence the development of the derivative technologies, products and services,- stimulate the delivery of Web capabilities compliant with the users needs and,- speed up and facilitate the usage of the Web infrastructure by European organisations, by disseminating the information and providing facilities and services to its members.A key aspect of the W3UserNet, relative to existing regional initiatives, is to leverage" these beyond their local spheres of influence and help them to secure access of European-e