RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cardiovascular Molecular Imaging for Personalized Tailored Treatment' (Neuroheart).

assistant: **Innovation**

Objectives of the proposal: Heart Failure (HF) is estimated to cost the EU economy €196 billion a year. Currently, patients are treated with the highest pharmaceutical doses of antiRAS agents, which cause severe side effects and reduce the patients’ quality of life. Moreover, treatment responses are highly variable. This study aims to enable imaging-guided treatment optimization by using a radiolabelled novel angiotensin 1 receptor (AT1) blocker analogue in a small animal model of myocardial infarction (MI). Positron emission tomography (PET) as a cutting-edge method of evaluating HF pathophysiology at a molecular level will be employed to optimize treatment.How the objectives will be achieved: MI will be obtained by ligation of the coronary artery in Wistar rats. Subsequently, PET imaging with a dedicated small animal system (mciroPET) will be performed. A multiple set of cardioneuronal PET tracers provided by the partner institution at Johns Hopkins University will be used to measure the extent of global and regional neurohumoral abnormalities in rat hearts following different degrees of ischemic insult. The relationship between neurohumoral system alterations and subsequent left ventricular remodelling will be determined by microPET and Magnetic Resonance Imaging to assess deterioration of ventricular geometric parameters. Using the novel AT1-ligand, imaging-guided dose-derived therapeutic concepts for Wistar rats will be established in vivo with the aim to transfer this technique to the clinic in a long term perspective.  Relevance to the Work Programme: I envisage that in the future a single cardiac PET scan prior to treatment initiation will be sufficient to estimate the appropriate drug dose in any given HF patient. This new concept of individualized drug dose de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Learning to bracket broadly', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

As a consequence of reforms of the social security systems in the EU, consumers increasingly face numerous investment decisions that involve risk, such as how to allocate their retirement savings between risky and safe assets. However, consumers often fail to make optimal choices. A key aspect in this context is whether and how people integrate (or “bracket”) the many different choices under risk they face. Evidence suggests that people often bracket narrowly, i.e., they view each choice in isolation and not in the context of the other choices they face, thereby often making choices that are not in their best interest. Understanding what determines how people bracket their choices is therefore of crucial importance. An important open question is whether people can (be induced to) “learn” to bracket broadly through a clever design (or “framing”) of the decision environment. I will investigate this question in a laboratory experiment to establish the scope and limits of learning to bracket broadly. Making the insights transferable across contexts and institutional features requires knowledge about the cognitive mechanisms of this learning. I use recent advances in neuroeconomics to gain a better understanding of these mechanisms using functional magnetic resonance imaging. The project will build on my initial experience in research on choice bracketing and complement this with the existing strengths in behavioral economics and neuroeconomics, as well as, the excellent research and training infrastructure at Maastricht University.The insights gained will lead to a better understanding of how individuals deal with multiple decisions involving risk and “the way consumers understand and choose financial services” (European Consumer Agenda).  The project will contribute to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Chirality via Cross-Coupling: New Asymmetric C-C Bond Formations Driven by Atom and Step Economy' to be submitted under Horizon 2020.

assistant: **Abstract**

Over 60% of the world’s top selling small molecule drug compounds are chiral and, of these, approximately 80% are marketed as single enantiomers. Surprisingly, and despite the tremendous advances made in catalysis over the past several decades, the average “chiral complexity” of drug discovery libraries has actually decreased, while, at the same time the “chiral complexity” of marketed drugs has increased. Consequently, there is now an urgent need to provide efficient processes that access directly privileged chiral “3D” building blocks. It is our philosophy that catalysis holds the key here and new processes should be based upon atom and step economical platforms that exert control over both absolute and relative stereochemistry. Palladium catalysed cross-coupling reactions of aryl (pseudo)halides with organo-nucleophiles (esp. the Suzuki coupling) have become mainstays of the pharmaceutical industry. Here, multiple “concession” steps are usually required to prepare the reaction partners, thereby detracting from atom and step economy. Further, these processes predominantly provide planar “2D” structures and are not well suited to the production of chiral “3D” building blocks. Consequently, methods that allow feedstock precursors (e.g. alkenes and aryl C-H bonds) to be combined directly in enantioselective or enantiospecific C-C bond formations are highly desirable. Cross-couplings of this type would circumvent “concession” steps, thereby minimising cost, effort and waste; however, such processes are highly challenging because of issues associated with regio- and stereocontrol. Recently, we developed prototype catalyst systems that can address this. In the proposed ERC project, these exciting preliminary results will be developed into a wider family of processes where a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chiral separation of molecules enabled by enantioselective optical forces in integrated nanophotonic circuits' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Separating enantiomers is crucial to produce bio-active molecules, e.g., in early-phase drug discovery. CHIRALFORCE aims at a radically new strategy to separate enantiometers on chip, using chiral optical forces at silicon-based integrated waveguides. The present solution of chiral chromatography for this multi-billion market is slow and cumbersome since it requires tailored chemistry for each chiral compound, and relies on large and expensive separation columns. Instead, CHIRALFORCE envisions cm-length optical circuits integrated with microfluidics for extremely quick, tuneable, and cheap enantiomeric separation. The underlying mechanism relies on optical forces that are enantioselective, due to interaction of spin-properties of the optical field with the chiral optical polarizability of matter.  These chiral optical forces can be tailored well beyond the possibilities of free-space chiral light through nanophotonic design of strongly confined modes. Flowing analyte in microfluidic channels along cm-length laser-driven will then result in enantio-separation.The approach to reach our main objectives relies on three main consortium strengths. First, we will design and synthesize chiral molecules and nanoparticles that will allow us to explore chiral forces regardless of how the chiral polarizability of matter is tuned by the size, shape, and in-built spectroscopic resonances, Next, we will establish the general framework of chiral optical forces on nanoparticles and molecules in liquid environments, leveraging our strength in nanophotonic theory, design and experiment, on chiral/spin-properties of electromagnetic  fields. Finally, we will leverage our experience in nanotechnology to fabricate silicon-based photonic integrated circuits integrated with microfluidics to dem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Willing to Pay? Testing Institutionalist Theory with Experiments' (WillingToPay) under Seventh Framework.

assistant: **Objectives**

The project will combine experimental techniques and methodologies with historically informed institutionalist analysis in order to more fully test and explore the relationships between institutions, policy regimes and citizen’s policy choices in different welfare states. The research will extend the current work in experimental economics and cognitive science by designing experiments that are modeled on real world institutions and policy choices in several different countries.Specifically we will focus on two sets of redistributive policy issues: Taxation and public pensions in four democratic nations: Sweden, Italy, Britain and the United States. The basic point will be to build a series of scenarios that will allow us to test how different institutional contexts frame or shape citizens’ decisions and thereby better understand how they perceive and process different policy choices and trade-offs.Throughout the study, historical institutionalist country specialists will work intensively with the experiments in each round, so that we can both refine the experiments in ways that can make them more realistic within different national contexts, but equally importantly so that we can build experiments that will test the specific hypotheses generated by these country specialists.I believe that only when we better understand both what citizens in different polities actually believe about their state, and why, can we build realistic models to understand how their policy systems can be reformed or adapted in the context of the enormous pressures they face today.  This research will thus combine the strengths of classical historical institutionalist analysis with recent developments in cognitive and evolutionary science and decision theory.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting the role of a novel transcriptional regulator in microbial-host interactomes' to be submitted under Seventh Framework.

assistant: **Abstract**

Pseudomonas aeruginosa is a versatile bacterium that can inhabit many environments. In its natural environments, Pseudomonas predominantly grows in organized communities called biofilms. Growth as a biofilm is also an important requirement for the colonization of human tissues. For instance, P. aeruginosa grows as a biofilm in the lungs of cystic fibrosis (CF) patients. Previously, it has been shown that nfxC-phenotypic isolates of P. aeruginosa associated with decreased early attachment - the first phase of biofilm formation. This chloramphenicol resistant nfxC-phenotype is thought to be caused by the activation of a LysR-type transcriptional regulator, MexT, which regulates the expression of the MexEF-oprN efflux-system. Recently, we have shown that this biofilm phenotype is a result of the activation of MexT in a MexEF-oprN independent manner (Tian et al., 2009). To further establish the role of MexT in biofilm formation, preliminary flow-cell biofilm experiments have been performed. Analysis of the biofilm structure showed that biofilms of cells overexpressing MexT contain a higher microcolony-density with smaller average size as compared to control cells. These differences were independent of the MexEF-oprN efflux system. This project aims to dissect how MexT modulates biofilm formation. Several potential candidate genes have been identified using a transcriptome approach of cells overexpressing MexT, which will be subject to further evaluation (Tian et al., 2009). To further establish the role of MexT on virulence phenotypes, eukaryotic cell lines, as well as a ‘state of the art’ infection model that uses zebrafish embryos will be used. This study may identify potential targets for the modulation of biofilm formation. In the long term, these targets may provide ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Array of coupled nanoresonators' (ACRES) under Seventh Framework.

assistant: **Objectives**

A novel system based on NEMS resonators will be developed. An array of coupled nanoresonators with a transduction based in the strain of thin layers of metal will be developed. To do that, analytical studies, FEM simulations, design and fabrication will be performed. The characterization will be done in three steps: measure frequency response of the system and characterization of the mass sensitivity (outgoing phase) and its use as a biosensor (return phase).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Building Sustainable Research capacity for Health and its Social Determinants in Low- and Middle-Income Countries' (SDH-Net) targeting Seventh Framework.

assistant: **Abstract**

SDH-Net’s aim is to build, strengthen and link research capacities for health and its social determinants (SDH) in African and Latin American low- and middle income countries (LMIC) in close collaboration with European partners. The focus on SDH will allow for an in-depth and broad capacity-building approach, including managerial and technical excellence, ethical issues, and research strategies. Lessons learnt will be checked against best practices and success factors in other Latin American, African and global settings, leading to lessons learnt on how to build SDH-related research capacity with strong relevance to the respective context.A sound mapping exercise of (i) social determinants of health (SDH) and research activity in the field; (ii) national and global stakeholders in the research environment, and (iii) existing research capacities in the participating countries will be carried out building the basis for developing and piloting innovative research capacity building tools with a particular focus on research management, ethics and methodology relevant to comprehensively address social determinants of health. Finally, links between research and policy will be forged and lessons will be drawn to support the development of sustainable and attractive research structures and expertise.SDH-Net will be carried out by a strong consortium, based on clusters of existing networks of best in its kind public health institutions from Mexico, Colombia, Brazil and South Africa, Tanzania, and Kenya. The team is complemented by three distinguished European institutions: London School of Hygiene and Tropical Medicine; COHRED, and University of Geneva. SDH-Net is coordinated by GIZ with long term experience in health research and capacity building in LMIC, and IESE Business Scho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Natural and Artificially Influenced Swash-Groundwater Interactions Experiments' (NATARISE) under Seventh Framework.

assistant: **Objectives**

Effective management of coastal erosion is a major stakes for the European Union. In a context of global warming and overpopulation of the coasts, the overall purpose of this project is to improve understanding of the hydrosedimentary processes affecting the instantaneous land-sea interface (the beachface), at the origin of an erosion or accretion of a coast. The objectives are:  (1) To study the impact of the various types of marine waves on the swash/beach groundwater/sediment transit interactions, starting from experiments carried out on 4 beaches representative of the Europe’s sandy coasts (North Sea, Atlantic and Mediterranean beaches). (2) To investigate the instantaneous effects of the drainage influence over swash in/exfiltration speeds and volume in order to improve the understanding of the operation of an innovative and promising - but still badly understood - method of fight against coastal erosion: the Beach Dewatering Systems. Response to these objectives will be made by the use of innovative experimental field methods (measurement of swash in/exfiltration speeds, use of a BDS for artificially generating erosion/accretion conditions), and by the data processing and analysis within the host institution (Coastal Group - University of Utrecht), highly recognized in the field. The obtained results will allow a better understanding of the physical aspects of the swash infiltration/exfiltration parameters, and to render BDS applicable to the greatest number of sites. Skills and knowledge acquired by Adrien Lambert (the applicant) within the framework of this project as its cooperation with the host (Associate Prof. Gerben Ruessink) will contribute to the quality of the results, like improving and widening the field of expertise of the applicant for his future rec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Interaction of Elasto-inertial Turbulence and material microstructure – INTER-ET' (INTER-ET) targeting Horizon Europe.

assistant: **Abstract**

Transport and handling of complex fluids is an important contributor to World energy consumption (10% is estimated to come from pumping suspensions), and improving their mixing and heat transfer is a key for new applications from process industry to medicine. A tiny amount of polymers, making the fluid viscoelastic, can completely change its flow, reducing turbulent friction and pumping power by around 70 % at large scales, but creating a whole new kind of turbulence at small scales. Elastic turbulence has recently received exponentially increasing attention, as a promising way to increase mixing and heat transfer at small scales (e.g. lab-on-a-chip applications), efficient cleaning and storage of fluids in the ground, but also as undesired source of chaotic flow paths and friction (cell sorting, blood flow). However, large gaps exist in understanding elastic and elasto-inertial turbulence, between conflicting experiments and theories, and multiscale interactions needed to sustain it.The INTER-ET proposal will revolutionize the state-of-the-art understanding of elastic fluids turbulence and its interaction with material microstructure, by synergetic simulations and experiments that were impossible until now. This will be achieved by our high-fidelity methods that for the first time enabled three-dimensional studies of elastoviscoplastic fluid turbulence, suspensions of tens of thousands of particles, and experimental time-resolved measurements on microscale. Theories for Newtonian turbulence do not hold for elastic fluids, and there is an urgent need for improved theories and models in wall-bounded turbulence of complex fluids. INTER-ET proposal aims to: i) perform the first simulations and experiments of EIT in matching wall-bounded geometries, ii) apply methods for di