RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Reprogramming lung epithelial cell lineages for regeneration'.

assistant: **Objectives**

In chronic adult lung diseases both tissue homeostasis and repair are disrupted, regeneration mechanisms fail, and healthy cells are replaced with aberrant cells. My long-term vision is to overcome these problems in patients with early-stage lung disease by in vivo reprogramming of cell fate to induce regeneration and restore cellular homeostasis. To achieve this we will move beyond the current state-of-the-art for human lung cell culture and human lineage-tracing, employing new physiologically-mimetic culture methods optimised in my lab which allow the ecosystem of cell states present within a tissue to be interrogated together. Focusing on interstitial lung diseases, which are primarily caused by epithelial dysregulation, we will acquire the biological framework to test the hypothesis that intrinsic cell reprogramming can promote human lung regeneration. We will determine how the lineage-dynamics of complex airway epithelia vary with airway generation in development, homeostasis and chronic hypoxia, which is a consequence of multiple lung diseases. This crucial information will be pivotal for inducing cell fate transitions that follow naturally occurring cell lineages, which will be the most efficient and stable routes for reprogramming in the adult. In parallel, we will ‘decode’ lung cell fate by defining the gene regulation networks controlling differentiation, proliferation and quiescence of human lung epithelial cell types. This will allow us to predict, and functionally test, factors sufficient for cell fate reprogramming. These experiments will combine innovative human tissue models, novel genetic tools and systematic analyses of scRNA-seq data. These analyses of precise cell lineages and transcription factor codes will allow us to test whether in vivo reprogram
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cortical neuronal mechanisms of behavioural and cognitive deficits after sleep deprivation', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A significant portion of our life is spent asleep and we still do not know why. Chronic sleep deprivation and sleep disorders are experienced by millions of people in our society, and sleep loss has profound effects on brain activity and cognitive functions. Surprisingly, we still do not know what happens in the brain after sleep deprivation that makes us feel tired and impaired even in simple tasks. The objective of this project is to provide an understanding of neuronal mechanisms underlying behavioural, sensory and cognitive changes incurred after sleep deprivation, through a suite of state-of-the-art neurophysiological techniques and methodologies. We hypothesize that prior waking experience results in specific changes in the activity of cortical neuronal networks that in turn directly results in an impaired cognition and necessitates sleep. In order to address this hypothesis we will use visual stimulation, sensory gating and ‘oddball’ paradigms, spatial navigation and reaction time tasks in rats and mice in vivo. Furthermore, we will exploit conventional and conditional knock-out mouse models to investigate global and local effects of metabotropic glutamate and GABA receptors on wake- and experience-dependent changes in cortical neuronal activity during sleep deprivation. This work will not only help to explain specific mechanisms underlying behavioural and sensory deficits after sleep deprivation, but by doing so will pave the way towards more focused innovative research relevant for public health and safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'DNA Lattice-Encoded Information for Genotype-to-Phenotype Evolution of Self-Replicating Synthetic Cells' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Within the framework of DNA-ENC SYNCELLS I will develop a synthetic inheritable genome capable of Darwinian evolution which encodes for the phenotype of self-replicating synthetic cells. The defining principles of life, namely compartmentalisation, replication and evolution, will thus be realised in a completely synthetic system for the first time. Two types of DNA tiles – a stiff and a soft tile – arranged in a lattice will serve as bits of information, replicating, without any enzymes, via mechanical scission. The DNA lattice will further act as an artificial cytoskeleton specifying the mechanics and shaping the phenotype of synthetic compartments assembled on a microfluidic chip. After sequentially adding the DNA tiles and catalysts for lipogenesis, the synthetic cells will be subjected to multiple growth and mechanically initiated division cycles. Variations in the mechanical properties will influence the division rate and thus lead to evolution in heterogeneous populations. The evolutionary trajectory of the system will be studied under different selection pressures. Within this two-year fellowship, hosted at the Max Planck Institute for Medical Research in Heidelberg and supervised by Prof. Joachim Spatz, I will contribute to the fundamental knowledge of synthetic cells and enhance its applicability using programmable man-made materials. Greatly profiting from the synergy between my expertise on DNA nanotechnology and the host’s high-quality research on microfluidics, synthetic biology and biophysics, this interdisciplinary project will open up broad perspectives for cellular machines capable of autonomous cargo transport, pathogen recognition or as substrates for 3D-bioprinting and tissue repair in vitro and in vivo – the envisioned focus of my subsequent career
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bacterial, cellular and epigenetic factors that control enteropathogenicity' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding the establishment and persistence of bacterial infections in the gut requires integrating an ensemble of factors including bacterial and host components and the presence of other microorganisms. We will capitalize on 25 years of studies on the bacterium Listeria monocytogenes used as a model, to focus on three objectives which will significantly increase our knowledge of the bacterium, of the cell biology of infection and of the epigenetic reprogramming upon infection. Our aims are:- at the bacterial level : to describe for the first time, the proteomic landscape of a bacterium during switch from saprophytism to virulence. We will use a proteogenomic approach together with ribosome profiling, to  analyze the translation of the whole transcriptome after bacterial growth in several conditions, including in vivo, in order to barcode all the proteins which play a role in infection. This will open the way to assess the role of 1) small proteins; 2) internal translation initiation sites ; 3) the coupling of transcription and translation.- at the host cell level : To decipher the molecular mechanisms underlying the dynamics and role in infection of host intracellular organelles, starting with mitochondria. - At the host epigenetic level : To explore how the microbe reprograms host transcription and how tolerance to a commensal such as Akkermansia muciniphila differs from responsiveness to a pathogen insult, at the level of histones and mRNA modifications  by studying 1) chromatin remodeling, in particular histones modifications during infection ; 2) modifications of the epitranscriptome during Listeria infection and colonization with Akkermansia ; 3) whether there is an epigenetic memory of infection and colonization. This ambitious multidisciplinary project will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Foundations of quantum computational advantage'.

assistant: **Innovation**

In FoQaCiA, we will expand the theoretical basis for the design of quantum algorithms. Our view is that the future success of quantum computing critically depends on advances at the most fundamental level, and that large-scale investments in quantum implementations will only pay off if they can draw on additional foundational insights and ideas. While several powerful quantum algorithms are known, the basic techniques they employ are few and far between. Largely, it still remains to be discovered how to systematically harness the quantum for computation. We study four areas of quantum phenomenology: (i) Quantum contextuality, non-classicality, and quantum advantage, (ii) Complexity of classical simulation of quantum computation, (iii) Arithmetic of quantum circuits, and (iv) Efficiency of fault-tolerant quantum computation.These fields are chosen for two reasons. First, their progress is of great importance for the physical realisation and the broad applicability of quantum computation. Regarding (i), one of the simplest proofs of quantum contextuality, Mermin’s star, has recently been employed to prove (Bravyi, Gosset, König) that bounded-depth quantum circuits are more powerful than their classical analogues. We seek to expand this result beyond bounded depth. In (ii), we study the quantum speedup by shaving off the redundant part – the efficiently classically simulable. In (iii), we aim to provide more efficient techniques for gate and circuit synthesis, utilising the number-theoretic underpinnings of the problem. Regarding (iv), given the celebrated threshold theorem, and the fact that the error threshold is now known to be within reach of experiment, we will tackle the remaining challenge of reducing the cost of fault tolerance.The second reason for selecting the a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Crystal engineering of molecular magnets'.

assistant: **Concept**

The project is related to molecular magnets. The major preoccupation will be to understand the magneto-structural relationships and to establish predictive models by combing X-ray crystallography investigations, magnetic studies and theoretical calculation s. Routine like X-ray diffraction studies on single crystals will be performed in relation with the chemist to allow a fast knowledge of the crystal structure. The data will be further used for molecular modelling. A particular attention will be paid to the packing diagram and analysis of the intermolecular interactions valuable for the understanding the magnetic properties. The X-ray data will be used to calculate the electronic structure with theoretical methods based on Quantum Mechanics and Molecular Mechanics in order to interpret the magnetic properties (magnetic moments, magnetic coupling constant J). High-resolution X-ray diffraction studies will be used for the mapping of the experimental electron density. This experimental data should bring valuable chemical features like bonding (covalent, polar, ionic), polarities in weak interactions (hydrogen bonding), lone pair character, atomic charges, dipole moments and many other electron density-related physical characteristics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Sustainable Ballast Water Management Plant' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Maritime transport is of fundamental importance to Europe and the rest of the world. Over 90% of European Union external trade goes by sea and more than 1 billion tonnes of freight a year are loaded and unloaded in EU ports. Shipping is the most important mode of transport in terms of volume. Transfer of species in ballast water started as early as shipping trade.The movement of some 3 to 12 billion tonnes of ballast water (BW) in ships internationally each year has been responsible for the settlement of about 100 million tons of sediment. Its cleaning and the disposal of the ballast sludge produced involve enormous costs, (approximately 30.000 for a small bulk carrier). Besides these economic aspects, BW has been recognised as a major vector for t he translocation of aquatic species across bio-geographical boundaries. It is estimated that as many as 10,000 alien species of plants and animals are transported per day in ships around the world. As ships travel faster and world trade grows, organisms are better able to survive the journey, using the settled sediments as a substrate, and the threat of invasive species from ballast water increases.Aim of the project is the development of a new hybrid BW treatment technology (UV, filters and electrolysis) into a self-controlled BW treatment system. The main objective of the proposed project is the invention of an effective treatment technology incorporating non- permanent, seawater-generated active substances as a necessary measure to UV and Filter treatment technology. By producing active substances through electrolysis of sea- water, there will be no need to carry or store hazardous and corrosive chemicals onboard ships. It also represents a more economical alternative to using chemicals for treating large volume of ballast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assessing the role of hydrothermal alteration on volcano morphology, instability, and unpredictable volcanic hazards' (ROTTnROCK), addressing dissemination and exploitation.

assistant: **Impact**

More than 10% of the world’s population are at risk to the direct impacts of volcanic eruptions. Volcano monitoring aims to detect and correctly interpret volcanic hazards and to provide early and accurate warnings of impending eruptions. Yet, despite technical and scientific advances, volcanoes still produce unexpected explosive eruptions or sudden flank collapses. Each year, such unpredictable events result in volcanic disasters that devastate unprepared communities and destroy unprotected infrastructures. Previous work by the PIs indicates that volcanic hazards are caused by hydrothermal alteration, which progressively and imperceptibly changes the chemical and physical state of rocks inside a volcano, creating a soft and unstable (or “rotten”) interior. However, the link between “soft” volcanoes and unpredictable volcanic events remains enigmatic. The ROTTnROCK project aims to achieve a ground-breaking advance in our understanding of hydrothermal alteration processes that act inside active volcanic systems. Specifically, we will identify where and at which scales alteration occurs (WP1), explore the chemical fingerprint of alteration and effects on rock properties and strength using laboratory methods (WP2), and develop 4D volcano stability simulations and, therefore, an innovative and optimised hazard assessment workflow (WP3). The ROTTnROCK project combines innovative approaches from traditionally distinct geoscience disciplines (remote sensing, mineralogy and chemistry, rock mechanics, and modelling). This project will revolutionise our understanding of hydrothermal alteration and its effects on volcano hazards, and pave the way for strategies to forecast and mitigate unexpected volcanic events caused by hydrothermal alteration and circumvent disasters at volcano
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SCIENTIFIC PHILOSOPHY: RISE AND FALL OF A EUROPEAN IDEAL (1850s-1940s)' under Horizon Europe.

assistant: **Concept**

SCI-PHIL provides an in-depth historical and theoretical account of the rise and fall of the ideal of ‘scientific philosophy’ (SP) in Europe from the mid 19th century, when the notion emerged, to the 1930s, with the first international congresses on SP, and WW II, which put an end to the project. It focuses primarily on five geographical areas: France, Germany, Austria-Hungary, England and Italy, with a foray into the Russian context.It is original in two senses: (1) It accounts for a neglected chapter in the history of European philosophy in all its transnational and transcultural scope, as part of a multi-faceted process of articulation of a European intellectual space at times characterized by the conflicting pulls of political nationalism and scientific internationalization and tragically punctuated by two world wars; (2) It focuses on a decisive historical moment wherein the problem of relations between philosophy and the sciences emerged in its current configuration and constituted a burning issue that concerned the very scope and vocation of philosophy itself. Indeed, from the 1930s onwards, with Nazi-fascism and WWII, a sharp fracture between philosophy and science occurred, worsened by the Cold War years.  Today, in our age of specialist fragmentation, the stakes in bridging this rift have never been higher. Can philosophy contribute to mending the fragmentation of knowledge or is it destined to merely be one discipline amongst others? More than a century ago, scientific philosophers were asking exactly this kind of question. In fact, SP is not merely an antiquated locution to indicate what we now mean by ‘epistemology’ or ‘philosophy of science’, which are specialized fields in the current academic division of labour. On the contrary, it denoted the high hopes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated design of work environments for human oriented activities' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The focus of this project is to provide a set of software tools to design and evaluate a human centred work system for a proposed product.It does this in three ways: it integrates several stages of planning so that they can be carried out concurrently with product design, it provides software tools to evaluate the ergonomics, safety and health aspects of the design of the work system when it exists only in virtual form on the computer, it integrates some Industrial Engineering tools to evaluate the productivity of the proposed system.Existing procedures for pre-production planning are time consuming and error prone, may require several iterations, including modification to the product design, and, in many cases, the appropriate information is not easily available. The work needs to be done much more quickly and give workstations that are of better quality. The proposed software will be easy to use, modular, suitable for use by companies of all sizes (including SMEs) and sufficiently open for it to be relatively straightforward to link other software to it. It will provide a holistic view of the process and will enable non specialists to choose the most appropriate manufacturing configurations for the workers. Novel features are the integration of the Industrial Engineering evaluations with the ergonomics, safety and health evaluations, and the ability to simulate the work system dynamically.