RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Chemistry of Marine Natural Products from the Mediterranean' (CHIMICAMARINAANAPOLI), addressing dissemination and exploitation.

assistant: **Impact**

Bioactive marine natural products from nudibranchs and other marine organisms from the bay of Naples – Marine natural product chemistry is a dynamic field of research with most of the compounds currently known having only been discovered since 1990 and with an ever increasing number of newly discovered compounds per year. Marine invertebrates including organisms that are vulnerable to predators are a particularly interesting source of bioactive natural products, which often constitute their most important means of defence.Apart from the sheer numbers still to be discovered, newly discovered marine natural products also encompass unexpected new carbon skeletons partially featuring new bioactivities based on formerly unknown modes of action. Equally interesting as the elucidation of the structure of marine natural products is the elucidation of their ecological role for the organisms producing them. These studies are made more complex because of emerging evidence that microbes associated with marine invertebrates may be the true producers of many of the natural products that were previously assumed to be produced by their invertebrate host. In the course of the proposed project, marine natural products from the Mediterranean and the Bay of Naples in particular, will be isolated and their structures elucidated by modern spectroscopic techniques. Pharmacological activities of these compounds will be tested in collaboration with other groups in fields of bioactivity which will be based on the structure of the isolated compounds and on some preliminary in-silico screenings. The focus of the investigations will be on nudibranchs but will also include other not yet studied marine organisms, in particular if ecological considerations make them interesting objects of study. In th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European coordinated network of laser infrastructures' under Fifth Framework.

assistant: **Concept**

The Cooperation Network combines some of Europe's most important major laser infrastructures, capable of pushing the laser concept into new directions and opening new application fields for optical sciences and optical technologies. It consists of two subgroups, characterized by distinctly different size of their laser installations (pulse energies on the order of kJ and Joule, respectively). Both subgroups pursue well-specified tasks to improve the quality of access to external users by trans-national and inter-disciplinary cooperation between themselves and with other laboratories, moving towards the concept of a European Virtual Infrastructure". In addition, they will develop strategies to push laser research and technologies towards new frontiers in their respective areas. The goals will be pursued within the framework of network cooperation, complemented by Topical Workshops, Round Table Meetings and network-wide user meetings."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Brain-on-a-chip as a preclinical model tool for the screening of theranostic nanoformulations for neurodegenerative diseases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Despite all the progress and effort that has been made in the last few decades regarding the research on neurodegenerative diseases, the complexity of the human brain and the low efficiency of drugs that can cross the brain-blood-barrier (BBB), have halted significant breakthroughs in neurosciences. Motivated by the lack of an appropriate in vitro model to study brain-targeting nanocarriers, the aim of BrainChip4MED is to develop an advanced microfluidic preclinical tool to recapitulate the structural and functional aspects of the human brain tissue and BBB, using brain-on-a-chip (BoC) technology, to assess and study possible alternatives for the treatment of Alzheimer’s disease (AD). This breakthrough vision will be accomplished by exploring for the first time a novel and multidisciplinary strategy, where chemistry-, engineering- and biology-based approaches will be combined for the creation of a robust microfluidic 3D brain-model, combined with multiplexed biosensor system, for real-time screening of new nanotechnologically-designed drug BBB-targeting nanocarriers. In order to pursue this project, the researcher will carry out the outgoing phase at HMS/BWH - Harvard Medical School/Brigham and Women’s Hospital (USA), pioneer in the development of organ-on-a-chip (OoC) and biosensors, for a period of 12 months (WP1). The researcher will then return to INL - International Iberian Nanotechnology Laboratory (Portugal), for the final 12 months (WP2 and WP3), where novel engineered nanoformulation will be developed and tested on the BoC prototype. With BrainChip4MED the researcher will greatly expand her scientific expertise in the fields of OoC and nanotechnology, positioning her as a leading independent researcher, bridging the worlds of engineering and medicine. At the sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A functional framework for sparse, non-gaussian signal processing and bioimaging' (FUN-SP) under Seventh Framework.

assistant: **Objectives**

In recent years, the research focus in signal processing has shifted away from the classical linear paradigm, which is intimately linked with the theory of stationary Gaussian processes. Instead of considering Fourier transforms and performing quadratic optimization, researchers are presently favoring wavelet-like representations and have adopted ”sparsity” as design paradigm.Our ambition is to develop a unifying operator-based framework for signal processing that would provide the ``sparse"" counterpart of the classical theory, which is currently missing. To that end, we shall specify and investigate sparse stochastic processes that are continuously-defined and ruled by differential equations, and construct corresponding wavelet-like sparsifying transforms. Our hope is to be able to rigorously connect non-quadratic regularization and sparsity-constrained optimization to well-defined continuous-domain statistical models. We also want to develop a novel Lie-group formalism for the design of steerable, signal-adapted wavelet transforms with improved invariance and sparsifying properties, both in 2-D and 3-D.We shall use these tools to define new reversible image representations in terms of singular points (contours and keypoints) and to develop novel algorithms for 3-D biomedical image analysis. In close collaboration with imaging scientists, we shall apply our framework to the development of new 3-D reconstruction algorithms for emerging bioimaging modalities such as fluorescence deconvolution microscopy, digital holography microscopy, X-ray phase-contrast microscopy, and advanced MRI.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Tracing the Ontogenetic Evolution of Diet and Behavior in Neandertals and Anatomically Modern Humans in the Franco-Cantabrian Region. An Integrative study of 3D Tooth Wear Patterns' (3DFOSSILDIET).

assistant: **Innovation**

3DFOSSILDIET (Tracing the Ontogenetic Evolution of Diet and Behavior in Neandertals and Anatomically Modern Humans in the Franco-Cantabrian Region. An Integrative study of 3D Tooth Wear Patterns), aims to reconstruct both dietary patterns and biomechanics of the masticatory apparatus during ontogeny (somatic development and growth of an organism throughout its lifetime, from conception to adulthood, a span known as the Life History) in Neandertals and Anatomically Modern Humans in order to trace trophic variation and behavioral complexity, and the following questions will be addressed: 1) How did adult individuals care for sub-adults? 2) How did sub-adults become independent individuals? 3) How were relationships expressed within the groups? 4) Could social patterns reflect our evolutionary success?This project will implement the use of recently developed virtual methods (Dental Microwear Texture Analysis and Dental Topographic Analysis) for the analysis of both micro- and macro- dental wear patterns in both Neandertals and Anatomically Modern Humans as a proxy to infer biomechanics of the mastication (diet) and general use of the mouth (behavior) along the Life History of both human species.3DFOSSILDIET is interdisciplinary, bringing together expertise in microscopy, bioarchaeology, isotopic analyses, and paleoanthropology through an integrative methodology to document dental wear. The results will address how and if behavioral changes were reflected across the human groups who lived during Middle to Upper Paleolithic Transition at the Franco-Cantabrian Region. Furthermore, the advance of the study of dental wear will provide technological framework for the study of surface modifications of both biological and archaeological materials.


**Keywords:** Homo neanderthale
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Main group element catalysts and bond activation reagents' (MGPCAT).

assistant: **Concept**

In modern technological processes nearly 75% of all chemicals require a catalyst for their production. Moreover, very frequently the most demanding stages require a late Transition Metal based catalyst because of their exceptional ability to activate relatively inert non-polar chemical bonds such as H-H or C-H linkages. However, application of such systems is likely to become increasingly difficult, due to a lack of sustainable availability, together with the high cost and toxicity of these metals. Therefore replacement of precious Transition Metals with inexpensive, abundant, and (in most cases) less toxic Main Group element analogues is at the cutting edge of modern research. We propose to use an approach based on the application of the unique electronic properties of anionic boryl ligands to construct complexes of the Main Group elements with reactivity comparable to Transition Metal systems. Our main goal is to establish the fundamental ground rules for catalyst design in what is an entirely new area of endeavour contributing to the “cheap metals for noble tasks” strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'UNDERSTANDING THE CLOSTRIDIUM SPORE, A PREREQUISTE FOR DISEASE INTERVENTIONS AND EXPLOITATION' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Bacterial endospores are the most resistant life-forms on earth and the most important single feature of the genus Clostridium. Thus, whilst the pathogenesis of its notorious pathogens (C. botulinum, C. perfringens and C. difficile) is ascribed to the devastating toxins produced (neurotoxins, endotoxins and cytotoxins), it is their capacity to produce spores that lies at the heart of the diseases they cause. This is because spores play the pivotal role in the spread of infection (eg, C. difficile) and in foodstuff contamination and food poisoning (eg, C. botulinum and C. perfringens). The processes of spore formation (sporulation) and germination (return of the dormant spore to toxin-producing, vegetative cells), therefore, represent key intervention points. On the other hand, the majority of clostridia are entirely benign and can sustainably produce all manner of useful chemicals and fuels. Crucially, the regulation of chemical production is intimately linked to that of sporulation. Spores of benign species may also be used as a delivery system for treating cancer. Yet, despite the spore’s importance, little is known of the developmental processes of sporulation and germination. This is because research and training efforts on Clostridium spores are fragmented and there is no coherence between researchers working on pathogenic and industrially important species. CLOSPORE will address this deficiency by pooling the resources of Europe’s leading universities, research organisations and companies, to create an intersectorial Research and Training Programme that is multi-facetted, interdisciplinary and focused on clostridial spores. Accordingly, CLOSPORE will produce the innovative, applied research leaders of the future, able to tackle the big societal challenges facing E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of advanced reservoir characterisation and simulation tools for improved coalbed methane recovery (ICBM)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Objectives and problems to be solved:This project aims at establishing an understanding of the basic scientific phenomena of CO2-CH4 adsorption, desorption, diffusion and flow in coal seams. This is fundamental to the industry's ability to exploit CO2 injection technology for improved methane recovery and CO2 sequestration. Laboratory isotherm measurements for single gases have demonstrated that coal can adsorb approximately twice as much CO2 by volume as methane. However, it is widely accepted by many researchers that the physical chemistry of this process has not yet been fully understood, and there remains the possibility that there are other physical processes active within the reservoir, which could alter this ratio. Latest binary gas mixtures adsorption/desorption research have confirmed that the extended Langmuir isotherm, which is commonly implemented in a number of coal bed methane simulators for modelling binary gas adsorption/desorption, does not represent this phenomena accurately.Description of the work:The objectives of the project would be achieved through experimental and theoretical work to be carried by the project partners. This work would first involve the petrographical and petrophysical characterization of European coals followed by experimental characterization of sorption and diffusion behaviour of CH4-CO2 mixtures in coal. The relative permeability of the cleat-matrix structure in coal as well as the capillary pressure and adsorption/desorption characteristics of CH4-CO2 mixtures at high pressure/high temperature environments will be studied in the laboratory. The findings of the experimental work will be used to develop a compositional simulator, which will be validated using real field data provided by the industrial partners. The simulator wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Safe and accurate fetal monitoring'.

assistant: **Objectives**

During gestation and birth, problems are encountered in up to 15% of all births. Most problems are related to fetal hypoxia and preterm birth. It is estimated that every year over 30.000 babies in Europe suffer from birth asphyxia, despite the common use of monitoring. Recent Norwegian research (2013) revealed inadequate fetal monitoring is responsible for 50% of the cases where human error caused birth asphyxia (oxygen deficiency). It can be concluded that current monitoring technology does not detect vital information on fetal wellbeing, causing unnecessary risks which can eventually lead to fetal mortality. There is thus a clear market need for fetal monitoring technology that is accurate, safe (non-invasive) and easy to use. Nemo Healthcare, a high-tech startup company, is responding to this market need through the development of an innovative electrode patch and hardware/software module that can simultaneously record uterine activity and fetal heart rate. The solution of Nemo is characterized by unique and smart algorithms that can accurately and real-time filter contractions and the fetal heart rate from unprocessed abdominal electrophysiological signals, successfully eliminating noise or interference. The solution will be able to transfer the recorded data wirelessly. The solution will create a breakthrough in the field of fetal monitoring: it will result in better diagnoses, improved quality of care, a reduced number of birth-related problems, increased user friendliness (for medical staff as well as the patient) and lower healthcare cost (through remote monitoring, reduced treatment and avoidance of unnecessary surgery).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Oxidative stress and chronic diseases : exocyclic dna adducts as markers for disrupted genomic integrity and risk' under Fifth Framework.

assistant: **Concept**

Oxidative stress- and lipid per oxidation-induced DNA damage is implicated in human carcinogen sis. Ethno adducts can serve as exposure and risk markers due to ultra sensitive detection methods developed by us. According to existing EU guidelines the study of mechanisms of action is crucial for selecting appropriate models for high-to-low-dose risk extrapolation. This project aims to define the action principles underlying the formation and persistence of promutagenic ethno-DNA adduct. Exogenous factors and endogenous processes leading to their formation will be studied. Key parameters, I. e. repair functions, persistence of lesions and mutational specificity at the gene level, will be characterized in humans, rodents, Drosophilae and Ecolab, in particular at low-dose exposures. Thereof, assay kits for industrial application can be developed. This integrated approach will improve geotaxis risk assessment of oxidative stress-related DNA lesions.Etheno-DNA adducts as biomarkers of oxidative stress induced by dietary fatty acids and altered estrogen metabolism were studied in relation to human breast cancer. The ratio of 4- to 2-hydroxyestradiol (E) in serum and the level of etheno-DNA-adducts in WBC in premenopausal women was found to be highly variable. 4-Hydroxy-E, a metabolite of E implicated in redox cycling, and arachidonic acid were found to be synergistic factors in the generation of etheno-adducts in calf thymus DNA. These results support a mechanism whereby metabolic redox-cycling of 4-hydroxy-E leads to ROS and DNA damage, which could play a role in breast cancer etiology. High individual variations in repair activities for etheno-adducts were observed in colon tissues from colon cancer patients. The malondialdehyde modified DNA adduct (M1dG) can serve as a biom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coupled Polyoxometalate – Hydrogenase Catalysts for Photocatalytic Water Splitting' (POMHYDCAT) targeting Seventh Framework.

assistant: **Abstract**

Alternatives to fossil fuels are of rapidly increasing importance, driven by concerns over energy security, cost, and global warming. In response to these concerns, the EU has set the target of obtaining 20% of all energy from renewable sources by 2020. A key challenge in renewable energy is finding an efficient way to convert plentiful solar energy into a source of chemical energy which can be stored, used for applications such as transportation, and consumed without releasing carbon dioxide – that is, a means of using solar energy to split water into molecular hydrogen and oxygen. This fellowship aims to develop a novel approach to complete water splitting, taking an interdisciplinary approach that combines recent breakthroughs in polyoxometalate-based water oxidation catalysts and enzymatic hydrogen evolution catalysts. The proposed hybrid systems will be among the first complementary polyoxometalate-enzyme catalysts; they also promise to become the first molecular catalytic systems to efficiently split water under visible light irradiation in mild conditions.