RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Rhizobacteria for reduced fertiliser inputs in wheat' under Sixth Framework.

assistant: **Concept**

Rhizobacteria that associate with plant roots have been found to interact with cereal crops, giving benefits of plant growth promotion and/or protection against pathogens. The plant growth promotion effect, due probably to a combination of nitrogen fixatio n, mobilisation of nutrients in the soil and excretion of plant hormones, may permit reductions in N and P chemical fertiliser inputs for inoculated plants.The development and use of rhizobacteria inoculants can therefore contribute to reductions in pollution related to fertiliser inputs, and to boost protein content in cereals, an important quality trait. However, the mechanisms and the most beneficial conditions of plant growth promotion are still unclear, since field and greenhouse studies have to date lacked reproducibility. RHIBAC will study most promising/pre-characterised rhizobacteria identified in previous EU and national research projects in Europe, Brazil and Chile. It will aim to understand the mechanisms of plant growth promotion through experiments with genetically modified rhizobacteria and monitor root colonisation with reporter strains.The importance of plant genotype and role of root exudates in plant-rhizobacteria interactions will be studied using analytical chemistry and biomonitoring. Due to previous experience of the participants this project is in best placed to obtain reproducible, significant effects of plant growth promotion in wheat in pot trials and in the field, including large-scale demonstrations in different climatic zones. Encapsulation and seed coating will be tested for improving root colonisation and survival of the rhizobacteria in the soil, and compatibility with other plant growth promotion/protection products will be assessed. The project will last four years to permit extended
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A unique and innovative cleanliness test bench that allows to increase test efficiency and reduce costs for cleanliness assessment of hydraulic, automotive and aeronautic components and systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Most of the wear and fatigue problems suffered by hydraulic systems are caused by solid contaminants, usually generated during the manufacturing process of the components. These particles have a big impact in the reliability and life expectancy of the hydraulic systems, as well as in their efficiency and in their overall energy consumption. The state-of-the-art solutions for cleanliness evaluation need, at least, a contaminant extraction system, a drying oven and a microscope, all of it installed in a clean-room laboratory and operated by skilled technicians. Apart from complex, this is scarcely effective and very costly. OilSafe is an Italian SME funded in 1998. CLEAN CABINET is our disruptive solution for cleanliness testing. It integrates all the previously mentioned processes in a single and fully automated device, from the extraction to the image analysis. Our solution doesn’t need a laboratory, can be readily integrated in manufacturing lines and no skilled operators are needed. It is more efficient and is fully compliant with ISO16232. Moreover, the results are obtained much faster and the tests result, at least, four times cheaper. Its use will have a big impact in the quality of the hydraulic systems because it enables to perform more tests at lower cost. Initially, the target sectors will be machinery (construction, agriculture, etc.) automotive and aeronautic, although applications can be encountered in many sectors. A first prototype is already working with very good results. The goals of the project are to integrate the image analysis module and some additional features in a new prototype before launching it to the market and to develop the commercial network needed to sell it, first in Italy and then in the rest of Europe. The project will last 2 years wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Missing Migrants: Identifying and Shaping Obligations for Protection' in the context of a Horizon 2020 call.

assistant: **Objectives**

Every year, thousands of migrants go missing, leaving behind families, who suffer not knowing whether their loved ones are alive or not. These human tragedies have been acknowledged and recognised by key international actors, such as in the 2018 UN Global Compact for Safe, Orderly and Regular Migration. At the same time, the very term ‘missing migrants’ is not legally (or otherwise) defined and most broadly includes all migrants whose whereabouts remain unknown. While international organisations (IOs) engage with the issue of ‘missing migrants’, they each conceptualise the phenomenon differently, focusing variously on only those migrants that are lost at sea, die unidentified, are secretly deprived of liberty, those who appear to have been trafficked, or disappear into the informal economy.Against this background, MIRO will identify the key facets of an umbrella concept of ‘missing migrant’ (a legally informed empirical concept), which will facilitate the identification of key legal obligations across various domains of international law. This in turn will provide the basis for an analysis and critique of institutional practices. The project’s main goal is to identify and interpret international legal obligations regarding ‘missing migrants’ and accordingly critique and shape the practices of the EU (including its externalization practices), its Member States and pertinent IOs.The project’s aims will be achieved through doctrinal legal research, semi-structured interviews, four study visits to IOs, and an expert workshop. The project output will include two policy papers, two articles, one book chapter, conference presentations, and blog posts.The MIRO project will build on the applicant’s expertise on missing persons and enforced disappearances, who will pursue researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Process for reuse of object-oriented software assets' under Fourth Framework.

assistant: **Concept**

Etnoteam (the contractor of this PIE) develops software and offers services and consultancy in IT areas such as Telecommunication, MIS, System Software, Software Engineering. As everyone else, Etnoteam is facing an extremely challenging market, which requires high quality products/services, competing prices, and timeliness.With this experiment, Etnoteam wants to face this requirements through a substantial change of attitudes in its development processes, culture and organisation, exploiting Object Oriented Technology and Software Reuse.THE EXPERIMENTEtnoteam believes that to fully exploit Object Oriented Technology with respect to the above mentioned goals the focus must be on reuse, both of components and of application frameworks. For such reason not only technical issues will be undertaken, but also organisational and managerial ones. The road map to achieve these results will be developed along the following tasks:a) Tools deployment: evaluation and acquisition of the technology needed to achieve the planned results.b) Process improvements: evaluation of current development approaches and their modification towards a reuse paradigm.c) Measurement System: establishing of a measurement system for the quantitative characterisation of the reusability of software assets.d) Reuse oriented policy: establishment of a company-wide reuse policy, rewarding development and project management attitudes towards reuse.e) Training: attending of a set of courses held by top-level consultant in Object Oriented Technology.Two baseline projects will be put in the framework of this experiment:one is in the field of Telecommunications, and concerns an Operating Support System for the GSM network (OMC); the other one is an application which allows furnishers and purchasers to access (via
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ThrombUS+: Wearable Continuous Point-of-Care Monitoring, Risk Estimation and Prevention for Deep Vein Thrombosis' under Horizon Europe.

assistant: **Concept**

Deep vein thrombosis (DVT) is the formation of a blood clot within the deep veins, most commonly those of the lower limbs, causing obstruction of blood flow. In 50% of people with DVT, the clot eventually breaks off and travels to the lung to cause pulmonary embolism. Clinical assessment of DVT is notoriously unreliable because up to 2/3 of DVT episodes are clinically silent and patients are symptom free even when pulmonary embolism has developed. Early diagnosis of DVT is crucial and despite the progress made in ultrasound imaging and plethysmography techniques, there is a need for new methods to enable continuous monitoring DVT diagnosis at the point of care.ThrombUS+ brings together an interdisciplinary team of industrial, technology, regulatory, social science and clinical trial experts to develop a novel wearable diagnostic device for point-of-care, operator free, continuous monitoring in patients with high DVT risk. The device will combine autonomous, AI driven DVT detection based on a novel wearable ultrasound hardware, impedance plethysmography and light reflection rheography for immediate detection of blood clot formation in the lower limb. Activity and other physiological measurements will be used to provide a continuous assessment of DVT risk and support DVT prevention via serious gaming. The aggregated data will drive an intelligence decision support unit that will provide accurate monitoring and alerts. Extended reality will be used to guide experts to design exercises and patients to use the device optimally. ThrombUS+ is intended for use by postoperative patients in the ward, during long surgical operations, cancer patients or otherwise bedridden patients at home or in care units, and women during pregnancy and postpartum. ThrombUS+ will use big data sets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Alzheimer's Disease Diagnostics Innovation and Translation to Clinical Practice in Central Europe' under Horizon Europe.

assistant: **Concept**

More than 55 million people worldwide suffer from dementia. Alzheimer disease (AD) is the main cause of this fatal disorder, without any effective disease modifying therapy. Early diagnosis and lifestyle modifications can significantly reduce the costs of care and treatment. There is no conceptual plan implementing modern diagnostic methods in the clinical practice in Czechia and Slovakia. The interaction between universities and private sector developing molecular diagnostic tools is fragmented and lacking. Limited number of talented students are invested in applied AD-focused research. The aim of ADDIT-CE is to interlink two ecosystems in Brno and Bratislava region, embracing the full quadruple helix of innovation driving actors: excellent scientific teams from Masaryk University and Slovak Academy of Sciences, collaborating with top biotech companies: Geneton, BioVendor, and MultiplexDX. Societal actors will be represented by organisations such as Slovak and Czech Alzheimer Societies, Memory Center and Czech Brain Aging Study. The regional government will be involved via Ministry of Health Slovak Republic, and South Moravian Innovation Centre. The joined ecosystems will unite R&I activities focusing on new diagnostic methods and their applications and further interlink academia and business spheres by creating a pilot industrial PhD programme. ADDIT-CE will generate a joint cross-border strategy covering basic and applied research activities aiming on accelerating the development of new tools for preclinical AD diagnostics and lifestyle/pharmacological intervention monitoring. New cutting-edge technologies will be transferred into clinical practise. Results of ADDIT-CE will be used to develop the Slovak National Plan to Combat Dementia, to enrich the Czech National P
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'THE DIVIDING CELL MEMBRANE: A PROMISING TARGET FOR NOVEL ANTIBIOTICS' under Seventh Framework.

assistant: **Concept**

The world wide rise in multidrug resistant pathogens is a major healthcare problem, and both the World Health Organization and European Union have identified antimicrobial resistance as a public health priority. The number of novel antibiotics that enter the clinic has dwindled over the last decades, and the development of new antibiotics is urgent. Cell division is a logical antimicrobial drug target, yet there are currently no clinically approved compounds that target this process. One of the main reasons is that bacterial cell division, and especially the role of the cell membrane in this process, is poorly understood. Moreover, cell division is a robust process, and many potential lead compounds are likely to be missed in drug screens. The aim of my research is to elucidate molecular mechanisms of cell division, and to use this knowledge to support the development of novel antimicrobial compounds. I have made several discoveries that provide an excellent basis to pursue these objectives: (i) the discovery of an important cell division protein, (ii) the discovery that the membrane potential is involved in cell division, and (iii) the discovery that membrane curvature can function as a cue for protein localization. My research project will be (1) focused on the interplay between cell division proteins and the cell membrane, and (2) aimed at supporting the search for new antimicrobials. I will develop novel functional assays to detect cell division inhibitors, and I will develop assays to find compounds that kill non-growing cells. In addition, I will set up state-of-the-art bacterial cell biology assays to study, in real time, the effects of antimicrobials at the cellular level. This research will not only support the Biopharma industry in their search for next genera
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Quantum probability with applications to physics, information theory and biology'.

assistant: **Innovation**

One of the main goals of our project is to educate young researchers to be able to create a bridge between experimentalists, engineers and advanced mathematical research. We do not expect all the young researchers participating in our project to perform activities on the applied side. Only a fraction of them will be recruited with this specific goal. Our idea is to stimulate the interest for application in young researchers who have an advanced mathematical training and feel that the quality of their mathematics could benefit from the confrontation with problems that go beyond the narrow horizon of a single specialization.How to realize these goals ?At the host institution: weekly seminars, talks of renown scientists, short courses on topics of interest for the young researchers. On the network level: annual conferences, workshops, summer schools (Greifswald Krupp-Kolleg , Levico ClRM), short visits to other teams, exchange of progress in research by electronic newsletters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Synergistic treatment of solid tumours by engineering novel synthetic communication systems in T cells and Macrophages'.

assistant: **Concept**

In TeaM I propose a synthetic biology-based multi-cellular strategy to fight solid tumors, addressing the immunosuppressive tumour microenvironment (TME). WHY: Synthetic biology is transforming cell-based immunotherapies with control circuits in immune cells like T cells and macrophages. However, in solid tumours the TME renders these cells dysfunctional, limiting their efficacy. Innovative solutions are needed to address this unmet need and unlock the full potential of immunotherapies.WHAT: TeaM integrates synthetic biology, immunology, and artificial intelligence to arm CD8+T cells and macrophages with synthetic communication systems that sense the immunosuppressive TME and activate precise and localized therapeutic response.HOW: In the past years, also supported by an ERC Starting grant I made key contributions to mammalian cell engineering, addressing important bottlenecks with innovative solutions. Motivated by this progress, I am ready to challenge my know-how and investigate new frontiers in cell-based immunotherapies, driving revolutionary possibilities for cancer treatment.Leveraging my expertise in mammalian synthetic biology, we will design circuits that decode and reprogram the TME. Key innovations include: 1) Synthetic receptors targeting TME-specific molecules; (2) Humanized transcriptional activators; (3) Cell type-specific synthetic promoters devoid of off-target effects; (4) A Machine Learning model to optimize codon usage for balanced gene expression. These innovations will improve immune cell engineering for therapeutic interventions.IMPACT: TeaM will enable non-invasive real time characterization of TME dynamics under different therapeutic pressures improving our understanding of tumour responses, in preclinical studies. Moreover, it will be a breakt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Terrestrial and atmospheric carbon observing system infrastructure'.

assistant: **Concept**

TACOS-INFRASTRUCTURE aims to establish a novel infrastructure for monitoring the carbon balance of European ecosystems. We will integrate the existing atmosphericCO2 measurements made by European laboratories at 35 stations, and the existing flux towers measurements from 19 sites into a unified network. For atmospheric measurements, this implies the set-up of a calibration programme to monitor intercom arability among different laboratories. For flux tower measurements, this implies the set up-of an online data transmission system, which includes archiving, quality control and accessibility. Both atmospheric and flux tower measurements will be made available to end users on a common data center.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Inhibition of the T-cell receptor signalling pathway for treatment of T-cell lymphoma' in the context of a Horizon 2020 call.

assistant: **Objectives**

Non-Hodgkin lymphoma (NHL) is a form of cancer emerging from the transformation of a mature B- or T-cell lymphocyte. NHL is the 11th most common cancer in Europe, and the 10th most common cancer worldwide. Functional evidence of the key role of B-cell receptor (BCR) signalling in B-cell malignancies came mainly from works conducted in Dr Louis Staudt’s lab (National Cancer Institute, Lymphoid Malignancies Branch, Bethesda, USA) where the outgoing phase of the global fellowship would take place. Rapid translation of basic science discovery on the BCR signalling led to the development of a specific inhibitor of a key BCR pathway adaptor named Bruton’s tyrosine kinase (BTK), which was granted for accelerated approval both in United States and Europe by regulatory medical agencies.While the potency of BCR pathway inhibitors is currently revolutionizing the management of B-cell malignancies, peripheral (ie mature) T-cell lymphomas (PTCL) still share a dismal prognosis with a 10-year overall survival barely exceeding 15%. Previous work of the experienced researcher provides strong evidence that PTCL similarly rely on T-cell receptor (TCR) signalling pathway for survival. Targeting this pathway could then lead to discovery of potent therapeutic compounds for PTCL treatment. During the 2 years of the global fellowship, the researcher would first perform a TCR pathway small hairpin RNAs (shRNAs) loss-of-function screen in PTCL cell lines in the group of Dr Louis Staudt where the technic is already available and has been fruitfully applied to B-cell malignancies. Second, the researcher would identify potential pharmacological inhibitors of the previously identified targets both in vitro and in vivo in PTCL cell lines xenograft models. This second phase of the project would take p