RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Structure / Function analysis of RLPs'.

assistant: **Objectives**

Plants have evolved mechanisms to defend themselves. Defence mechanisms are often triggered after the direct or indirect interaction of a disease resistance (R) gene from the plant and an avirulence (Avr) gene from the pathogen. In the absence of the R gene or the Avr gene, disease ensues. Such gene-for- gene" interactions are known for many different pathogens and plants. R proteins can be divided into five classes based on their structure. The focus of my work will be on the Receptor-like Protein (RLP) class, of which Cf-9 is the founding member.RLPs are membrane-anchored glycoproteins with extra-cytoplasmic Leucine Rich Repeat (LRRs, a protein-protein interaction motif), a transmembrane domain and a short cytoplasmic tail lacking any obvious signalling domain. The Cf-9 protein has 27 LRRs, which are divided in two blocks. Domain Cl comprises 23 LRRs, and the second, domain C3, has 4 LRRs. In between there is a putative "hinge" region, which does not have any LRRs, called domain C2. Sequence alignments of C2 between Cf-9 and Arabidopsis RLPs (AtRLPs) reveal conserved amino acids. Amino-acids surrounding the C2 region are also well conserved.The aim of the proposed project is to:(i) investigate the functional significance of amino acids conserved between Cf-9 and Arabidopsis RLPs, using transient assays of mutated Cf-9 alleles in Nicotiana benthamiana and(ii) to make chimeras of Cf- proteins and Arabidopsis proteins, that can be transiently assessed in transient assays in turnip, to try establish a Cf-9/Avr9 response in Arabidopsis that can be used for genetic studies on Cf-9 signal transduction."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Textile Work Intelligence by hierarchical closed-loop control for product and process quality in the Textile Industry' (TEXWIN), addressing dissemination and exploitation.

assistant: **Impact**

The objective of TexWIN is to increase productivity by up to 20% and reduce down-times of machines by one third of workshop factories; due to a reduction of stop times, set-up times and waiting times, increased flexibility and reliability of processes, and due to reduced sampling effort. The breakthrough is to exploit existing knowledge available in various factory internal and factory external sources by (1) combining and evaluating process state information as well as product and material characteristics and (2) deriving best production instructions. Additionally existing production knowledge and experiences from production operators will be preserved and made available by the CBR module. This will be enabled by the hierarchical control structure TexWIN-Concept" consisting of an adaptive and modular system "TexWIN-System" and re-engineered "TexWIN-Processes" improving quality of products and processes of workshop factory operations. The “TexWIN-System" integrates the two following units: (a) the factory controller for the improvement of the process schedule and event-based coordination of factory (inter-)operations and (b) the adaptive CBR-based production unit controller for identification of best process recipes/machine settings concerning product quality and production process set-up and execution efficiency. The modules will be integrated into a common communication framework, which will enable flexible interfacing and ontology-based information transformation. The "TexWIN-Processes" are adapted factory business processes which allow maximising the efficiency and quality effects and seamless integration into existing factories. TexWIN, which will be tested within in 5 textile and plastic mills, will be best suited for industries dealing basically with make-to-orde
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The chemical exposome in pregnant women and metabolic dysregulations analysis towards the prioritization of hazardous chemicals'.

assistant: **Concept**

Expo-IS-omics is an interdisciplinary and highly innovative project in the field of human exposomics and bioinformatics. The main objective of EXPO-IS-OMICS is to obtain a holistic picture of both the external and internal chemical exposome in a large cohort of pregnant women to study which are the contaminants that can cause metabolic alterations. Once we know which contaminants are having more effects, we will develop new cheminformatics tools, capable to predict the chemicals with potential to dysregulate human metabolism based on in-silico predicted molecular predictors. EXPO-IS-OMICS will analyse samples of blood and urine of >200 pregnant women residents in Greece from the Rhea Cohort. This project will use state-of-the-art instrumentation to provide nontarget data at trace levels from a vast chemical domain, obtaining with the same data information of both contaminants’ presence (external chemical exposome) and specific alterations in the endogenous chemical profile (internal chemical exposome), by means of target, suspect, nontarget and metabolomics strategies. EXPO-IS-OMICS  will also be pioneer in developing cheminformatics tools to predict when a certain chemical may represent a problem to human health. For the development of the tool, experimental data from this project will be joined with others cohort’s results in which the applicant is currently involver and the principal investigators have agreed to share (e.g. BISC (https://www.projectebisc.org/) and Insulin (https://www.tecnatox.cat/list-of-projects)) for validation purposes. The expert knowledge of fellow and host group gives the security to reach the ambitious objectives.


**Keywords:** Human exposure, metabolomics, high resolution mass spectrometry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Evolutionary robustness of cell polarity during molecular diversification.' under Horizon Europe.

assistant: **Concept**

Cells are often viewed as intricate machines, in which specific proteins work together in a tightly coordinated fashion to give rise to cellular functions. Surprisingly however, some proteins that are essential for core cellular functions in one species are absent in closely related species, while the core function itself is maintained. How this robustness is achieved, while the underlying molecular networks dramatically diversify during evolution is currently not understood. As a post-doc I showed that the polarity network in yeast can evolutionarily adapt to the loss of an important protein by losing three more proteins. My lab showed that these losses repair polarity through a collective adaptive response, affecting many cellular processes rather than only a few proteins. How do intricate cellular networks collectively achieve such evolutionary robustness? We will address this question with a library of experimentally evolved polarity networks in budding yeast to (1)  investigate how general a collective adaptive response is, (2) examine which spatiotemporal aspects of polarity establishment are evolutionary robust, (3) determine how changes in (i) protein copy-numbers, (ii) post-translational modifications (PTMs), and (iii) buffering by self-organization, contribute to evolutionary robustness, and (4) dissect the molecular mechanisms. We will use transposon sequencing to identify the cellular processes involved, live cell microscopy to compare the robustness of various aspects of polarity, and mass spectrometry to compare changes in gene expression, PTMs and interaction partners. We will use multiscale simulations, rooted in statistical physics and constrained by our experimental results, to dissect how molecular changes propagate through the polarity network to ach
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NORA - Nitrous Oxide Research Alliance Training Network' (NORA), addressing dissemination and exploitation.

assistant: **Impact**

The fate of anthropogenic nitrogen is at the core of our environmental predicament. Human activities have more than doubled the annual input of reactive nitrogen to the biosphere compared to prehistoric levels, causing escalating emissions of nitrous oxide (N2O) which contributes to global warming and depletion of stratospheric ozone. Ultimately, anthropogenic nitrogen will return to the atmosphere, either as N2, N2O or NO, which are the gaseous products of microbial red/ox-transformations of mineral nitrogen. The N2/N2O/NO product ratio of these transformations is controlled by the ecology and regulatory biology of the organisms involved, modulated by environmental factors. We need better understanding and quantification of these processes to improve our chances to reduce N2O emissions from managed ecosystems (agriculture and waste treatment systems). Such progress requires interdisciplinary scientific approaches in collaboration with the fertilizer and waste-industries.NORA comprises the strongest research groups in Europe regarding the biochemistry, biotechnology, physiology and ecology of N-transforming microbes in soils and wastewater systems, the R&D of leading fertilizer-, waste treatment- and robot- industry. Major goals are to•  improve our understanding and predictive ability regarding the ecology and regulatory biology of microbes involved in oxidation and reduction of mineral N species affecting atmospheric N2O.•  produce a new generation of nitrogen researchers, within both academic and private sectors, with inter- and cross-disciplinary skills and understanding and appreciation of both fundament science and its direct application to environmental, industrial and societal issues.•  exploit the power of fundamental scientific understanding, developed through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'High Density Batteries for e-Mobility and Industrial Automated Guided Vehicles.'.

assistant: **Objectives**

HDBAT aims to develop and commercialize the next generation of high-energy (HE) and high-power (HP) Li-ion pouch cells for large e-Mobility and automated guided vehicle (AGV) HDBAT combines innovative cell design with novel materials and environmental-friendly water-based processes to develop high density cells with energy densities of 330 Wh/L (HE↑25% SOTA) and 200 Wh/L (HP↑70% SOTA) at energy costs of respectively 200 €/kWh (↓30% SOTA) and 450 €/kWh (↓45% SOTA), thereby meeting the needs of our customers for customized energy solutions and cost-efficiency. The result is a monocell architecture with double coated anodes and cathodes, 25% reduced collector thickness, NMC-622 and 811 nickel-rich cathodes and TiO2-nanorod coated anodes (Ultracharge technology). Moreover, battery production is realized with minimum environmental impact by innovative water-based production (no toxic NMP) and conform the latest EU safety and health regulations. To deliver advanced HDBAT cells to the market, our existing manufacturing line needs to be adapted and a feasibility study is required for assessing the scalability of the cells by water-based processes and analysing the requirements for adoption of the production line. From a commercial perspective, the market will be studied in-depth to assess the commercial and financial viability, and set-up a detailed business plan. To realize this innovation a total budget of 2.5M€ is foreseen for Phase 2. Upon commercialization of HDBAT in Europe, Asia and North-America (Q1 2020), sales are projected to increase from 350k cells in the first year to 950k by 2025, growing company revenues by CAGR of 28,4% to 49M€ with a positive ROI within 24 months and a total ROI of 6,1. 54 new jobs will be created as a result of the increased business activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mixed Augmented and eXtended Reality media pipeline'.

assistant: **Objectives**

MAX-R is a 30-month IA that will define, develop and demonstrate a complete pipeline of tools for making, processing and delivering maximum-quality XR content in real time. The pipeline will be based on open APIs, open file and data transfer formats to encourage development and support the integration of new open source and proprietary tools. MAX-R builds on recent research and advances in Virtual Production technologies to develop real-time processes to deliver better quality, greater efficiency, enhanced interactivity, and novel content based on XR media data.The interdisciplinary Consortium of eleven partners from five countries covers the chain from technology development and product innovation to creative experiment and demonstration, and from XR media creation to delivery to the final consumer. It is built around Europe’s leading media technology developers, together with creative organisations operating in AR/VR/MR, Virtual Production, interactive games, new media, TV, video and news, multimedia and immersive performance.


**Keywords:** Virtual Reality, Augmented Reality, Mixed Reality, Extended Reality,Real-time Virtual Production, Open APIs, Open Source
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced electrical machine manufacturing process implementation and tuning based on composite material process technologies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This topic aims to develop an optimized manufacturing process for the Open-Rotor demonstrator deicing system electrical machine based on organic matrix composite material processing technologies. The different tasks will design the manufacturing process, select the resin and optimize its process parameters, and then manufacture a demonstrator of an electrical machine. This advanced manufacturing will be based on composite material process technologies developed at Nimitech Composites with optimized process parameters and defect investigation determined at Ecole Nationale d’Ingénieurs de Tarbes.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Handmade: Understanding Creative Gesture in Pottery Making' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Human beings have always relied on the skills of the hand for exploring their creative potential. The process of making by hand lies at the intersection between embodied cognition and material culture – linking the plasticity of the brain to the incredibly variety of bodily techniques, materials and forms of material culture. Still, the full creative dimensions of this process as well as the changing relationship of the human hand with past and present material culture are not well understood and require cross-disciplinary research. This project aims to fill this gap in our knowledge focusing on one specific material with long archaeological history and cross-cultural significance, i.e., clay and the craft of ceramics. The morphogenetic potential and plasticity of clay offers a unique kinaesthetic resource for studying the creative ecology of handmaking and exploring questions about skill, memory, distributed intelligence, material agency, tradition and innovation. Our plan is to study pottery making at first hand through sustained multi-sited participant observation in several traditional ceramic workshops spread around mainland Greece and the Islands. We will use a combination of methods from anthropology, archaeology and embodied cognitive science to record, measure, describe, compare and analyse the exact ways by which craft practitioners use their hands to produce a variety of material forms. We shall be collecting our data using extensive video recording, photography as well as through semi-structured interviews and interaction analysis. Our research procedure, grounded on material engagement theory, is designed to facilitate a heightened responsiveness to the details of action and the properties of the materials and the tools involved. Our broader aim is to use o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High-resolution quantitative climate reconstructions for understanding current trends: the past 2000 years of Tasmanian climate variability' under Seventh Framework.

assistant: **Concept**

The last 2000 years form a critical period in global climate history. They span a significant length of time prior to major anthropogenic influences on climate and include the shift to industry-based societies. Lack of data from the Southern Hemisphere limits our understanding of climate change and ability to differentiate and delineate interactions between natural, forced and stochastic variability. High-resolution data spanning the last 2000 years from key locations in the Southern Hemisphere are urgently needed to advance climate research globally. Tasmania is a key location for climate studies. The climate is dominated by the Southern westerlies and influenced by the El Nino Southern Oscillation and Southern Annular Mode. Previous palaeoclimate work has demonstrated records contain a genuine Southern Hemisphere climate signal. In-situ multi-channel reflectance spectroscopy (RS) is a novel approach for reconstructing temperature and precipitation from lake sediments. A series of lake sediment cores will be collected along the dominant climate gradient in Tasmania (west-east). In-situ RS in combination with high-precision chronologies developed using 210Pb and 14C will be used to reconstruct temperature and precipitation over the last 2000 years. TASCLIM is the first study of its kind in the Australasian region. It will produce high-resolution quantitative climate reconstructions with known uncertainties, significant new data and contribute to better understanding of regional, inter-hemispheric and global climate change and dynamics. The University of Bern and related institutional networks (OCCR, NCCR Climate, IGBP-PAGES) offer world-class facilities with a unique range of scientific expertise and excellent network for scientific exchange and transfer of knowledge. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Comparison of High-Dose Heamodiafiltration (HDF) versus Haemodialyse' (HDF) under Horizon 2020.

assistant: **Objectives**

End stage kidney disease ranks among the most severe chronic non-communicable diseases with an unmet medical need, given the high (between 10 and 15%) and stable annual mortality rates. Kidney replacement therapy is necessary when kidney function is below 10% of the normal value. Much effort is put into developing strategies to prevent chronic kidney disease progression. Regenerative medicine still is in the experimental phase and kidney transplantation is only available for a small number of patients. Indeed, the everyday reality is the growing number of dialysis patients. Haemodialysis treatment is the current standard of care for the vast majority of patients with end stage kidney disease. It is a substantial burden to the patient and for society. Haemodialysis treatment is associated with high risks for fatal and non-fatal cardiovascular disease, for infections, hospitalisation and low quality of life. Improvement in the currently available standard is urgently needed. Over the past decade an alternative for haemodialysis became available, i.e. haemodiafiltration. Both are accepted by regulatory authorities. Haemodiafiltration removes waste products that are accumulated due to kidney failure, more effecticvely than standard hemodialysis. Present evidence supports the idea of superiority of haemodialfiltration compared to standard haemodialysis. However, definite proof is lacking and as a consequence haemodiafiltration is not yet widely applied. This consortium aims to determine the best possible dialysis treatment by comparing the conventional guideline based haemodialysis treatment versus high-dose haemodiafiltration by carrying out a prospective randomized controlled clinical trial addressing clinical endpoints, quality of life and a cost-utility analysis. The stu