RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intermarriage and ethnic identity' (IMEI).

assistant: **Innovation**

An important element of social cohesion and contact between majorities and sub-state ethnic minorities are intermarriages, which are either welcomed as vehicles easing the tensions between nations and sub-state minorities, or criticized as important drivers of assimilation and the destroyers of ethnic minority communities. The social aspects, family dynamics and identity construction of family members in intermarriages were not studied methodically in CEE and the WB. Therefore, the goal of the Intermarriage and Ethnic Identity (IMEI) project is to analyse the social implications of intermarriages between members of ethnic minority communities and the majority nations in Vojvodina, the multiethnic region of Serbia. The IMEI project will contribute to the state-of-the-art by analysing the social impacts of intermarriages on three levels, namely the individual (micro), the family (meso) and the societal (macro) in a significantly multi-ethnic geographic region. On the individual level the project will examine ethnic and cultural identity transformations undergone by partners in intermarriages. On the family level we will explore the processes of intergenerational transfer of ethnic, religious and cultural markers. On the societal level the project will investigate the workings of the relevant and quite modern ethnic minority policies and legal framework of Serbia and their impact on intermarriages. This research is relevant in the wider European context as well, as we will specifically target the Hungarian, Slovak and Romanian ethnic minorities living in Vojvodina, whose kin-states (Hungary, Slovakia, Romania) are members of the European Union, whose members often have dual Serbian and EU citizenship and are therefore subject to the Framework Convention for the Protection
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unraveling and targeting mitochondrial biogenesis in CD8+ T cells to improve memory formation and vaccine efficacy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Immunological memory is the basis of vaccination. This has been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells (TM) remain largely undefined. Recently, it was shown that CD8+ T cell responses following bacterial infection could be manipulated by modulating cellular metabolism. Since then immunometabolism has emerged as one of the main frontiers in science, and my research is leading in this field. I recently demonstrated that the promotion of mitochondrial biogenesis (MB) and fatty acid oxidation (FAO) in CD8+ T cells during an immune response is crucial for their development into long-lived TM cells. An important regulator of MB and FAO is the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) family, and my preliminary data suggest that PGC-1 has a role in TM development. My proposal focuses on the novel concept that cellular metabolism and MB regulate CD8+ TM cell development. Importantly, this concept offers possibilities for pharmacological manipulation of TM formation.My objectives are (1) to determine the role of PGC-1 in mitochondrial metabolism during CD8+ TM development and (2) to investigate whether agents that promote MB enhance vaccine efficacy. For objective 1 I will generate CD8+ TM cells in vitro, and determine whether PGC-1 deficient CD8+ T cells have a defect in functional TM cell formation due to impaired mitochondrial metabolism. In addition, I will determine whether PGC-1 deficient CD8+ T cells will form functional TM cells in vivo. For objective 2 I will test whether MB-inducing drugs can improve TM cell development and function, both in vitro and in vivo. My project will provide insight into the mechanism of MB and TM development, and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Demonstration and development of the next generation technology for environmental dredging based on an innovative and energy-efficient freeze technology', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Scandecon´s innovation project aims at bringing the next generation technology and methodology for environmental dredging to the market. The core of Scandecon´s solution is a unique freeze technology that uses 75 % less power, shortens the time for freezing by 50 % and lowers costs by 30 % compared to other dredging methods. This is combined with a set of services that covers the entire value-chain for dredging, handling and disposal of contaminated sediment - making it a unique offer that sets a new standard for environmental dredging. Scandecon´s solution will initiate a paradigm shift in environmental dredging by allowing for new possibilities for cost-, time- and resource efficient removal of contaminated sediment at levels that can endanger marine life and human life. Applying Scandecon´s technology on polluted environments in soil, rivers, lakes and oceans will help states, municipalities and businesses to save hundreds of millions of Euro on dredging and handling of contaminated sediment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structural and biophysical characterization of the human mTOR kinase and its signaling complexes' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Cell growth and proliferation are fundamental processes whereby organisms accumulate mass and are therefore tightly regulated. Regulation is achieved by a complex network of signaling pathways responding to various environmental cues. A crucial nutrient and energy-sensitive pathway is centered on the Serine/Threonine kinase mechanistic target of rapamycin (mTOR). In the cell, mTOR interacts with several proteins to form two multi-subunit signaling complexes: mTORC1 and mTORC2. mTORC1 responds to the intracellular energy state reflected in amino acid and oxygen levels and integrates extracellular signals from growth factors to control cell size and proliferation. mTORC2 responds to growth factors and its downstream targets regulate cell survival and cytoskeletal organization. Consequently, deregulation of mTOR signaling is directly linked to human disorders like obesity, type II diabetes or cancer, which makes mTOR a highly relevant pharmaceutical target.Although several aspects of mTOR signaling have been understood, the lack of intermediate to high-resolution structures impairs detailed understanding of complex assembly, function and regulation. We therefore propose to determine the structures of human mTOR complexes and their subunits by X-ray crystallography. The intended research involves initial medium-throughput expression screening of mTORC1/2 subunits in bacterial and insect cells followed by a biophysical characterization of the expressed proteins. Guided by the biophysical analysis, we will establish in vitro reconstitution protocols and identify promising candidate complexes for high-throughput crystallization screening, crystal optimization and structure determination. The structures should provide first insights into the organization of human mTOR (sub)comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Process diagnostics for plant performance enhancement'.

assistant: **Concept**

The objective of this accompanying measure is to extend the work previously carried out within PROGNOSIS (EP22281). The aim of PROGNOSIS was to demonstrate, on a wide-range of production processes and products, the comprehensive improvements that could be achieved in plant performance through the off-line application of Multivariate Statistical Process Control (MSPC). PROGNOSIS II aims to extend the technology to at-line and on-line process performance monitoring on four different processes. MSPC has been shown to be a generic tool capable of monitoring the performance of all variables on continuous or batch plant and their plant-wide interactions.The basic research work to establish the potential of the methodology on single unit operations, or single plants will have been carried out with prototype software applied off-line by the industrial partners in PROGNOSIS. The research content of PROGNOSIS II is directed at the further developments in MSPC necessary for its robust application in an industrial environment both at-line and on-line and its extension to handle the monitoring of inter-connected process operations. MSPC is currently being evaluated in the USA at-line and on-line by a number of companies, in collaboration with McMaster University. However, in Europe, the only studies undertaken in industry to date are within PROGNOSIS. This project addresses for the first time the at-line and off-line implementation of the technology in Europe. The University of Newcastle and Aristotle University of Thessaloniki have jointly developed expertise in the techniques of MSPC for both continuous and batch processes. Access to plant and data collection facilities will be provided by the partner companies, BASF (complex reaction plant); Ceat Cavi (compounding); Solvay (batch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Evolution of mutator bacteria in a community context'.

assistant: **Objectives**

The proposed fellowship is designed to provide to a promising post-doctoral specialization in the microbial evolutionary ecology field by pursuing a period of training in Centre for Ecology and Conservation, College of Life and Environmental Sciences at University of Exeter in the UK. Under the supervision of a world’s leading expert in this field, and with further theoretical training, the Fellow would employ this 2 year period to develop and expand upon her highly commended PhD research into how the evolution of Pseudomonas aeruginosa mutation rates is affected by natural microbial communities.This goal will be carry out by taking two different approaches: i) to study what is the impact of natural competitors in the evolution and adaptation of mutator bacteria in a soil community context by using a direct experimental evolution system; ii) to investigate what is the role of community complexity in the selection of P. aeruginosa mutators in cystic fibrosis (CF) chronic airways infections by exploring the correlation between community diversity and prevalence of P. aeruginosa mutators in artificial and natural CF communities. The project will be interdisciplinary; bridging the gap between microbial ecology and clinical microbiology fields and having broad ecological and medical consequences. In addition, with the inclusion of a return phase, this proposal will foster long-term collaborations between Exeter University, UK and Universidad Nacional de Cordoba, Argentina; favoring the transference of knowledge and enhancing EU scientific excellence in research related to microbiology,  evolutionary ecology and infectious diseases in order to extend the current state-of-the-art of mutator bacteria evolutionarydynamics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular electron transport junctions: spectroscopy of vibrational effects and their controlled manipulation' (ElecTrans), addressing dissemination and exploitation.

assistant: **Impact**

It is proposed to experimentally study electron transport through molecular junctions and the influence of electron-phonon interaction on the transport, using current-voltage characteristics and inelastic tunneling spectra, while molecular vibrations in the junction are excited with infrared radiation. It has been predicted from theory that the non-equilibrium vibrational distribution will strongly affect the electron transport and that the molecular junction will effectively act as an optical switch. In combination with inelastic tunneling spectroscopy the proposed approach method may well prove to be very powerful in examining electron transport paths in molecules. Apart from simple organic molecules, also a redox protein, Azurin, will be used as sample, to explore relevance for the emergent field of bioelectronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'modelling of integrated water systems under uncertainty for aquatic environment rehabilitation in rapidly urbanised catchments'.

assistant: **Objectives**

Many catchments in developing countries are undergoing rapid urbanization, in which water systems become a fusion of natural water bodies, rivers, and man-made water networks. It has also been widely recognized that rehabilitation of the aquatic environment is essential in maintaining the system's ecological and hydrological balance, especially under rapid urbanisation. There have been a number of EU projects, e.g. NeWater and AquaStress, on adaptive and integrated modelling of catchments, but very few have investigated adaptive measures necessary for rapidly developing countries. Modeling of these water systems poses a significant challenge and requires a change in thought paradigm in order to deal with rapid spatial-temporal changes in the physical elements and the associated catchment responses. Two case studies from Southern China, Maozhou river catchment and Shenzhen river catchment, would be carried out to demonstrate the reliability and effectiveness of the approach. The two catchments are both located in rapidly urbanised area of China but have different urbanisation level. Aquatic environments in the two catchments have been severely damaged due to tempestuous disturbances of human activities. The adaptive modelling approach would be applied to support decision making for aquatic environment rehabilitation in the catchments.  The objective of the project is to develop a novel framework of adaptive approach to model the integrated water systems, which is subjected to rapid changes over a relatively short period of time, effectively. It is envisaged that within the proposal framework, various simulation models, optimisation techniques and uncertainty analysis methods are integrated on a common platform to build up the fully integrated model of water system. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Method and database to adapt metal finishing to the environment' in the context of a Fourth Framework call.

assistant: **Objectives**

Metal finishing is an essential process in all manufacturing, offering corrosion and wear protection and performance related to surface characteristics. For corrosion only, there are losses estimated to 4 % of GDP or about 300 billion ECU annually within the EU, of which 15 % or around 50 billion ECU could be saved with better use of existing technology. Environmental effects from the processes have gained extensive attention and implied large changes in the industry. So far, the changes have mainly been focused around waste water treatment, waste handling and closed loop technology, close to the plants. However, metal finishing has a most significant impact on the environmental effects caused backwards and forward in the production chain of a product, the use of the product and the disposal or recycling of the product. There are huge environmental benefits throughout the life cycle of a product that could be gained with wiser metal finishing. These include energy and material savings at production, reduced emissions and waste volumes, more efficient and prolonged service lives and increased recycling of scrapped products. MADAME will develop a method and a database for evaluation of the total environmental effects of a metal finishing process. The tool shall give a reasonable correct picture, but yet be simple to use for SME suppliers of metal finishing. Thus, they may profile themselves by adaptation to the main issue of today and gain market among the growing part of the 380 000 metal manufacturing companies in the EU, and many more in other countries, with increasing environmental requirements. MADAME has an agreed research methodology, a strong consortium, comprising process suppliers, metal finishers and end users, and an exploitation plan, utilising trade organis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Interconnection of European research and university networks at 34-155 mbit/s' under Fourth Framework.

assistant: **Concept**

This project is financed by the joint research networking initiative of Esprit and the Telematics Applications Programme, and by the ACTS programme.JAMES is a collaborative project between 18 European network operators to research the use of ATM technology for broadband networks. The project aims to develop a Europe-wide ATM-based interconnection structure together with associated experimental services to meet the requirements for implementation of a European High Speed Network for Research in response to a growing user demand for higher bandwidth services. Connectivity for experimental use between the National Research Networks and European research projects (e.g. Esprit projects, National Hosts, ACTS Projects) is provided over an ATM bearer service based on the trans-European network infrastructure established for the European ATM Pilot.The JAMES project is to experiment, test and evaluate the provision of new ATM-based broadband services and applications throughout Europe. These experiments will use traffic originating from National Research Networks and National Hosts.The major objectives of the JAMES project are to: - Establish the user requirements in terms of type of service, features, quality of service metrics, time scale and support, in collaboration with the users. - Prioritise user requirements and define a trial plan for each service required, - Assess the market potential and projections for trans-European broadband services, - Plan, design, build and operate the underlying infrastructure, building on the experience and capabilities of the ATM Pilot, - Validate end-user services and prove end-to-end operability through experimental trials carrying user traffic,- Obtain and exploit feedback from the experimental users (particularly National Research Network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Memory-Related Information Processing in Neuronal Circuits of the Hippocampus and Entorhinal Cortex' (HIPECMEM) under Seventh Framework.

assistant: **Objectives**

This proposal will elucidate the circuit mechanism that underlies the spatial memory-related information processing in the interconnected brain areas of the hippocampus and entorhinal cortex (EC). Both of these areas are implicated in spatial memory and encode spatial information in neuronal activity patterns. The mechanisms underlying the emergence and coordination of spatial memory-related activity in these regions are needed to understand how these circuits process mnemonic information. Accordingly, here we aim at elucidating the representation of spatial memory by investigating these mechanisms at the circuit and synaptic levels of organisation. The first objective of this proposal is to characterise oscillatory synchronisation in hippocampo-EC circuits at different stages of memory processing. We hypothesise that network oscillations facilitate circuit interactions during memory processing. Therefore, using optogenetic techniques to disrupt oscillations, we aim at identifying critical periods during mnemonic processing when synchronisation is needed. Secondly, we intend to reveal how mnemonic information is encoded and exchanged between different areas of the hippocampo-EC system. We will test whether spatial memory-associated firing of dorsal hippocampal cells could be triggered by EC and/or ventral hippocampal cells that encode similar mnemonic features. In addition, this project will explore the role of temporal coding in the representation and consolidation of spatial memory traces. The third objective will investigate synaptic changes between connected CA3-CA3 and CA3-CA1 cell pairs during spatial learning. We will use cross-correlation analysis and electrical microstimulation to examine the rules that govern changes in synaptic efficacy by observing the proba