RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The First non-cancerogenic Glyoxal Acid-Free fixative for a Formalin-free hospital' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

ADDAX Biosciences is an academic spin-off of the University of Torino, born after long time research activity of its founders on the pathological tissues. Our company goal is to replace the use of Formalin (a cancerogenic solution of formaldehyde) as fixative, while preserving optimal tissue fixation to guarantee correct diagnosis and therapy.In the European Union, Formaldehyde is recognized as a carcinogenic substance, and its use, production and commercialization is prohibited from August 2017. However, at present there is no valid alternative to Formalin accepted by the scientific community to preserve patient specimens.Our project proposes a huge step forward in the fixative market by introducing an innovative reagent, based on acid-free Glyoxal (GAF), that will allow the optimal tissue fixation at structural and molecular level, combined with the absence of toxicity and carcinogenic activity. The addressable market of our GAF product is primarily represented by the healthcare segment, thus the targeted users and clients are public and private entities performing pathology services, such as: Hospitals, Clinics, Emergency Medical Services, Diagnostic Laboratories, Academic Institutes, Forensic Laboratories, CROs, Veterinary Clinics, Labs and Hospitals.Our business model is initially based in two distinct phases: the first one aimed to achieve a controlled production capacity to serve the first customers and finance the further investments; in the second phase, from second year, we expect a faster scale-up through outsourcing production agreements with major European producers of chemical and pharmaceutical products. In this scenario, Addax will retain the R&D, quality, scientific and market development. The objectives of our Feasibility Study are to validate at Europ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Meta-stable Smart Metamaterials for Actively-controlled and Reversible Transition waves' (Meta-SMART).

assistant: **Innovation**

Mechanical metamaterials play a crucial role in various applications, such as shape morphing, soft robotics, and logic elements. However, the control and guidance of transition waves within these materials have primarily been static. The Meta-SMART project aims to revolutionize this by actively controlling and guiding transition waves using piezoelectric and shape memory polymer-based multimaterial active switches integrated into metamaterial unit cells. Unlike traditional methods, Meta-SMART offers dynamic and reversible control, allowing the metamaterials to adapt autonomously and universally.To optimize these smart metamaterials, we will implement a machine learning-based inverse design strategy to determine their geometrical parameters. Fabrication will involve 3D printing, followed by experimental testing of transition wave control and guidance. This innovation promises to advance the industrial applications of mechanical metamaterials, offering adaptability to external forces and desired outcomes. Potential uses include controlled energy absorption and dissipation for airflow control in aircraft, selective energy absorption in protective surfaces, and even treatment of Parkinson’s disease.The Meta-SMART project represents a valuable opportunity to expand my expertise in smart materials and structures, enhancing my research profile through hands-on experience in testing and fabrication. Training activities such as TU Delft's teachers' training program, workshops on supervising research projects, and advanced courses in machine learning and 3D printing, will equip me with the skills needed for a successful academic career in the smart materials and structures field, aligning with my long-term goals.


**Keywords:** Mechanical metamaterials, Wave guide, ML based inve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Boosting the international profile of IST projects in the networked audiovisual systems and home platforms field to capitalize on and exploit results' (BIP).

assistant: **Concept**

BIP is a Specific Support Action (SSA) with an overall objective to support the IST projects involved in, and the D2 Unit in charge of, the area of Networked audiovisual systems and home platforms". More specifically, BIP focuses on the field of Home networks and platforms.Three main support activities are developed:- Supporting the projects and the Unit in their involvement in 3 major events: Net-atHome2003, Net-atHome2004 and a workshop in Beijing in 2005. For the Net-atHome events, BIP will make sure that the visibility of the IST programme and of the participating projects is important, and will provide IST projects with complimentary passes and exhibition areas. For the workshop in Beijing, BIP will organise it in a way that the IST visibility and that networking opportunities for IST projects are the highest possible. BIP will also organise technical visits of local key sites to complement the Beijing workshop programme.- Supporting the D2 Concertation mechanism, in liaison with the AVISTA project, another SSA also committed to bring a support to this mechanism. More specifically, BIP will organise, and contribute to the moderation of, the Concertation meetings of those IST projects addressing the field of Home networks and platforms. BIP will also prepare a Portfolio analysis supporting the overall documentation expected as an output of the Concertation mechanism.- Developing active promotion and dissemination activities to ensure project promotion and therefore maximise its interest and impact, and widely disseminate its outcomes. To this end, a project web site and project documentation are developed and made available at an early stage of the project, as well as a Plan for using and disseminating knowledge, regularly updated all along the project. Project mana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unraveling Multiscale Embolism Dynamics in Plant Leaves through Biomimetic Models' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Embolism, the formation of air bubbles in a plant’s vascular system responsible for water transport (the xylem), disrupts the flow of water and nutrients, leading to hydraulic failure. With the increasing frequency of droughts due to climate change, embolism has become a leading factor in the decline of forests worldwide, contributing to tree mortality and ecosystem collapse. Understanding how embolism forms, spreads, and is repaired in plant tissues is critical for predicting plant resilience to water stress, but current models lack the necessary data to make sufficiently accurate predictions.The EMBIOMO project employs a multidisciplinary and multi-tool approach to address this challenge. By integrating on leaves ultra-fast optical imaging, advanced 3D micro-CT, and confocal microscopy, the project will capture embolism propagation with unprecedented temporal resolution and at high spatial resolution. In parallel, biomimetic systems replicating key aspects of plant leaves xylem will be developed to study embolism under controlled extreme conditions, such as negative pressure. These biomimetic models will not only help investigate embolism dynamics but also serve as validation platforms for advanced theoretical modeling of vascular flows in intricate fluidic networks. This synergistic combination of approaches will significantly advance the state of the art in plant hydraulics, enabling unprecedented mechanistic insights into embolism propagation, generating unique databases and opening unique perspectives for fluidic network dynamics studies, beyond plant vascular systems. The outcomes will be transformative, providing novel predictive models of plant vulnerability to droughts and contributing critical data to improve resilience strategies in agriculture and forest ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Resonant clustering'.

assistant: **Objectives**

The extent to which nuclei can comprise lighter nuclear clusters in low-mass systems directly influences astrophysical production and decay rates. However, the scope of clustering away from stability has yet to be fully investigated. This proposal will address this by implementing novel measurement apparatus for exotic clustering in key short-lived isotopes using resonant elastic scattering and at the same time demonstrate an improved spectroscopic tool that can be applied to a wide range of nuclear structure studies. This is possible because of key charged-particle detector expertise of the ER and the Supervisor complementing both the ER's experience in radioactive ion beams and the MC40 cyclotron facility at Birmingham. Birmingham's world-class leadership in clustering and charged-particle spectroscopy make this location an ideal host. The result is a focused proposal that will lead to a flexible tool for extracting precise structure data from radioactive beam experiments, answering questions at the frontiers of nuclear stability, models and nuclear astrophysics. A significant reduction in beam-time required for such investigations will be achieved making the apparatus practical for use at international user facilities while opening more systems to this technique and reducing background.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Life quality of senior citizens in relation to mobility conditions' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

European policy regarding the elderly aims at maintaining their mobility. This is a central element of integration in society. Often it looks as if experts know too little about elderly citizens: Senior citizens want to lead an autonomous and independent life as far as possible. The focus of SIZE is on the present mobility situation, the problems, needs and wishes of different groups of senior citizens, and parallelly on experts' view on all this. To learn this will be achieved with the help of qualitative and quantitative survey instruments, and with the help of multidisciplinary discussions, based on the survey results, in the frame of four Workshops where industry, policy makers and politicians will discuss about the results of SIZE together with senior citizens representatives and the SIZE consortium. The final product is a list of problem types and respective solution types to mobility and transport problems of senior citizens.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Interraccions between citotoxic T lymphocytes (CTLs) and Human Immunodeficiency Virus (HIV): viral cost of escape from immune system and implications in vaccine desing' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

HIV infection is one of the major global health problems of our times and one of the main priority research areas in EU policy for the FP6 program. Although natural immune control of HIV infection can occur, vaccine development has been hindered by difficulties in identifying what immune responses need to be induced. HIV-specific cytotoxic T lymphocyte (CTL) activity plays a central role in control of HIV.Thus, great variability exists between different CTL in their effectiveness. Recent studies have shown that MHC class I alleles (such as HLA-B57 in HIV infection) are associated with very successful control of viral replication. The dominant epitope targeted by B57-positive subjects is a peptide in p24 Gag, sequence TSTLQEQIAW (Gag residues 240-249), and in the great majority of cases the virus escapes recognition by CTL as a result of a mutation at residue 242 from ThrAsn (T242N).However, control of HIV is still maintained well. Subsequent works of Dr. Prado has shown that a contributing factor to this sustained control of HIV by B57-positive subjects is the fact that this T242N mutation inflicts a cost to viral replicative capacity. Thus, immune control of a now attenuated HIV is achieved more readily by remaining B57-restricted CTL responses.These studies together with further preliminary work indicate the importance of this mechanism of immune control. The main objectives of the proposal will be: to define further the CTL responses that are effective in control of HIV, and to explore the escape mutation s that inflict a significant cost to viral replicative capacity.These objectives will be achieved with the incorporation of Dr Prado to the host institution to integrate her previous knowledge into a new research field. This information will be of direct relevance t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Average - Transaction Costs and Risk Management during the First Globalization (Sixteenth-Eighteenth Centuries)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project focuses on the historical analysis of institutions and their impact on economic development through the investigation of a legal instrument – general average (GA) – which underpins maritime trade by redistributing damages’ costs across all interested parties. This will be pursued through the comparative investigation of GA in those European countries where substantial data exists: Italy, Spain, England, France and the Low Countries (1500-1800). Average and insurance were both created in the Middle Ages to facilitate trade through the redistribution of risk. Insurance has been widely studied, average – the expenses which can befall ships and cargoes from the time of their loading aboard until their unloading (due to accidents, jettison, and unexpected costs) – has been neglected. GA still plays an essential role in the redistribution of transaction costs, and being a form of strictly mutual self-protection, never evolved into a speculative financial instrument as insurance did; it therefore represents an excellent case of long-term effectiveness of a non-market economic phenomenon. Although the principle behind GA was very similar across Europe, in practice there were substantial differences in declaring and adjudicating claims. GA reports provide unparalleled evidence on maritime trade which, analysed quantitatively and quantitatively through a novel interdisciplinary approach, will contribute to the reassessment of the role played by the maritime sector in fostering economic growth during the early modern first globalization, when GA was the object of fierce debates on state jurisdiction and standardization of practice. Today they are regulated by the York-Antwerp Rules (YAR), currently under revision. This timely conjuncture provides plenty of opportuniti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A new generation of AptaSensors' under Horizon 2020.

assistant: **Concept**

The aim of this project is to design different next generation libraries of biosensors that will yield ready-to-go analytical tools against any target in unprecedented speed and high affinity. The project intends to focus on aptamers, a new generation of recognition elements that will be integrated into bioelectronics devices. The huge number of candidates to be tested using a combinatorial trial and error approach will be radically reduced by rationalizing the strategy to design the aptamers. A new virtual screening process will be used for the generation of aptamers by the help of modern molecular modelling tools. The design and binding of large database will be created and screened by adding or mutating molecule bricks (amino acids and DNA), minimizing experimental tests and therefore reducing the research costs.These sensor elements will be organized in medium to high density nucleic acid and peptide arrays with different transducing principles. In particular, we will design and produce an electrochemical sensor array platform based on screen printing technology together with suitable extraction- and pre-concentration procedures by coupling aptamers to nanoparticles.The analytical procedures produced will be tested using first standards and then real samples. The target molecules will be analytes related to health and safety control (Xenobiotics: e.g. PCB, pesticides. Mycotoxins: e.g. patulin, nivalenol, Antioxidants: e.g. resveratrol, luteolin).The proposal has strong focus on development of concrete evolutionary new biosensors for application to diagnostics, food, terrorism threat agents, environmental and new frontiers analysis such as bioanalysis in the space.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Research Training Network on Integrated Component Cycling in Epithelial Cell Motility' (InCeM), addressing dissemination and exploitation.

assistant: **Impact**

Cell migration (cell motility) is a fundamental biological process that is pivotal in (i) tissue formation and repair (health) and (ii) tissue invasion during carcinogenesis (disease). Understanding and controlling cell migration will have major clinical impact. Clarifying mechanisms driving cell motility has been challenging due to the complex underlying cellular mechanisms; these involve multiple components coordinated by structural, chemical and physical signals in terms of time and space. To accomplish breakthroughs in this field, researchers are needed who (i) master cutting-edge experimental techniques for monitoring the different cellular processes at high resolution and (ii) have competencies in theoretical science for integrating the resulting data sets into mechanistic mathematical models for predicting motile cell behaviour.The Research Training Network on Integrated Component Cycling in Epithelial Cell Motility (InCeM) aims to endow up-and-coming researchers with exactly these competencies. They will be able to develop and apply innovative devices for microscopic recording, image processing techniques, data analysis tools and modelling procedures for mechanistic understanding of cell migration. InCeM will focus on epithelial cells, since inducing motility in this cell type is clinically relevant for wound healing and cancer invasion. The ultimate goal is to control and manipulate cell migration for clinical applications. A dedicated multidisciplinary team of 11 beneficiaries from universities (4), research institutions (4) and industry (3), based in 5 European countries and Israel, together with 17 associated partners from the public and private sector, will train 15 Early Stage Researchers (ESRs) to use the relevant technologies and sciences and will offer