RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular mechanisms of cohesin-mediated sister chromatid cohesion and chromatin organization' (CohesinMolMech) targeting Horizon 2020.

assistant: **Abstract**

During S-phase newly synthesized “sister” DNA molecules become physically connected. This sister chromatid cohesion resists the pulling forces of the mitotic spindle and thereby enables the bi-orientation and subsequent symmetrical segregation of chromosomes. Cohesion is mediated by ring-shaped cohesin complexes, which are thought to entrap sister DNA molecules topologically. In mammalian cells, cohesin is loaded onto DNA at the end of mitosis by the Scc2-Scc4 complex, becomes acetylated during S-phase, and is stably “locked” on DNA during S- and G2-phase by sororin. Sororin stabilizes cohesin on DNA by inhibiting Wapl, which can otherwise release cohesin from DNA again. In addition to mediating cohesion, cohesin also has important roles in organizing higher-order chromatin structures and in gene regulation. Cohesin performs the latter functions in both proliferating and post-mitotic cells and mediates at least some of these together with the sequence-specific DNA-binding protein CTCF, which co-localizes with cohesin at many genomic sites. Although cohesin and CTCF perform essential functions in mammalian cells, it is poorly understood how cohesin is loaded onto DNA by Scc2-Scc4, how cohesin is positioned in the genome, how cohesin is released from DNA again by Wapl, and how Wapl is inhibited by sororin. Likewise, it is not known how cohesin establishes cohesion during DNA replication and how cohesin cooperates with CTCF to organize chromatin structure. Here we propose to address these questions by combining biochemical reconstitution, single-molecule TIRF microscopy, genetic and cell biological approaches. We expect that the results of these studies will advance our understanding of cell division, chromatin structure and gene regulation, and may also provide insight in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Scandium-based multifunctional nitrides for optoelectronic, polaritonic and ferro/magnetoelectric devices' (SCOPE) targeting Seventh Framework.

assistant: **Abstract**

Device performance is ultimately limited by material properties. To break existing performance limits, I plan to develop a new multifunctional Sc-based nitride materials platform in which tuneable semiconducting, ferroelectric and magnetic functionalities may be achieved for the first time. I can then address three major challenges: (1) solving a 20-year-old problem in solid-state-lighting using highly efficient green light-emitters, (2) creating the first electrically pumped full-spectrum polaritonic lasers, and (3) developing an optimised artificial synapse for adaptive computing (plus similar related non-volatile memory devices). Combined, such advances could lead towards the “spintronics dream” of devices with integrated optoelectronic, photonic and magnetic functionality. Importantly, the mature growth and device processing technologies in place for conventional nitride semiconductors will allow rapid exploitation of this versatile new group of materials.A theme is planned for each objective. At Stage 1 (months 1 – 30), I plan to grow and characterise crystalline thin films of the Sc-based nitrides relevant to each theme, aiming to control the structure and properties of the individual layers and simple heterostructures from which devices will be constructed. Themes 1 and 2 will use specific Sc/III-nitride alloys created by molecular beam epitaxy, a flexible industry-proven growth technique. Theme 3 will explore and use a broad range of transition-metal/ScGaN alloys created by electron-beam epitaxy, a relatively low-cost technique optimised for transition metals. Full experimental data on layer properties will be input into models, which will be used to design full device structures. Optimised device designs will be chosen at Month 30. At Stage 2 (months 31 – 60),
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '“Alcohol-impaired driving PREVENTion and personal authentication by a vehicle ignition interlock system“' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

One of the greatest challenges we face in this regard is the level of safety of different means of transport, especially road transport, being one of the most widely used one, is safety.  Every day, millions of EU citizens use the roads. Statistics is more than eloquent – in 2014, 25,700 people did not make it home and more than 200,000 people came home with life-changing, serious injuries. For the period 2003–2013 , the total number of road casualties equaled 422,569 (the population of a mid-sized city). In addition to the fatalities, the number of people injured in this period was 18 million. Furthermore, the social cost of road accidents is officially estimated to have cost EUR 130 billion  per year. One of the main problems associated with road safety is driving under influence. About 25% of all road fatalities in Europe are alcohol-related . As the Blood Alcohol Concentration (BAC) in a driver increases, the crash rate also rises.  Biodit Global Technology strives to provide an adequate solution of the problem related to drink-driving through the development and commercialization of an innovative non-invasive alcohol ignition interlock device which has the highest level of accuracy, compatibility with existing ignition systems as well as additional layer of security preventing manipulation of tests. During the Phase 1 we aim to examine the economic viability of the project and gain further detailed knowledge regarding the target market, including better understanding of the market segments, end-users needs and preferences as well as identify potential risks and bottlenecks for the further commercialization of the PREVENT device. Phase 1 project will conclude with the development of an elaborate business plan outlining the strategy for product development and commer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'High Precision Composites Moulding-Prediction of Distortion Using Analytical Methods' (1994-1998) under Fourth Framework.

assistant: **Objectives**

A MAJOR ADVANTAGE OF USING COMPOSITE MATERIALS FOR PRECISION TOOLING AND FOR STRUCTURES SUCH AS AIRCRAFT, IS THE ABILITY TO PRODUCE COMPLEX SHAPES. UNFORTUNATELY, IT IS DIFFICULT TO ACHIEVE THE REQUIRED ACCURACY FIRST TIME SINCE DURING THE CURE AND POST CURE OF COMPOSITES, DIMENSIONAL CHANGES OCCUR WHICH LEAD TO ERRORS. THIS OFTEN ENTAILS NEW TOOLING AND SEVERAL RE MAKE ATTEMPTS BEFORE SATISFACTORY PARTS ARE PRODUCED. THIS COSTS THE INDUSTRY A GREAT DEAL AND EXTENDS THE TIME TO MARKET BY MANY MONTHS. THE PROJECT: IT IS PROPOSED TO CARRY OUT A PROJECT TO OBTAIN A FULL UNDERSTANDING OF THE PHENOMENA AFFECTING COMPLEX 3D COMPOSITES MOULDING DISTORTION AND TO DEVELOP A KN OWLEDGE BASED TOOL CORRECTION PREDICTIVE SOFTWARE DATA BASE. AS A FIRST STEP, ACG LTD WHO HAVE BEEN AT THE HUB OF PRECISION COMPOSITES DESIGN AND APPLICATION FOR THE PAST 20 YEARS, PROPOSE TO CARRY OUT AN EXPLORATORY STUDY TO IDENTIFY THE MARKET POTENTIAL FOR A HIGH PRECISION MOULDING PREDICTIVE SOFTWARE SYSTEM, CLARIFY THE PATENT/COPY RIGHT SITUATION AND TO DEFINE A DETAILED RTD PROPOSAL TO PUT THE MATTER ON A SOUND SCIENTIFIC BASIS. AS A SECOND STEP, A SIMPLE DEMONSTRATOR WILL BE DEVELOPED BASED ON EXISTING COMPANY DATA, AND A 2D FINITE ELEMENT MODEL. AN INVAR MALE TOOL WILL BE USED TO SHOW THE 'SPRING BACK' DISTORTION FROM A 'DRAWING SIZE' TOOL AND AN ACCURATE MOULDING FROM A PREDICTIVELY CORRECTED TOOLS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Singlet Oxygen Strategy: sustainable oxidation procedures for applications in material science, synthesis, wastewater treatment,    diagnostics and therapeutics""' (SO2S), addressing dissemination and exploitation.

assistant: **Impact**

The SO2S network seeks to exploit Singlet Oxygen (1O2) as a green and benign oxidant for use in novel synthetic methodologies, crosslinking strategies, bioconjugation procedures and materials production. The chemistry described herein generates the means to both understand and influence biological systems by providing probes and reagents – from analytical methods to new drugs - and to modulate materials towards optimal properties.Training in this area is highly interdisciplinary in nature requiring the joint efforts and contributions of chemists, physicists, biologists and material scientists. Ultimately our understanding and further development of singlet oxygen mediated oxidations should lead to useful applications in the fields of organic chemistry (improved routes towards natural products), medicinal chemistry (targeted delivery and novel diagnostics), physical chemistry (controlled singlet oxygen generation), and materials science (novel materials for water treatment  and new arrays for improved diagnostics). The global objective of this network is to train young researchers to become skilled individuals that meet the current challenges of working in an interdisciplinary industrial environment wherein chemistry often forms the basis, but where it is utilized in a truly diverse range of applications.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dna recognition and photophysical properties of groove-located dinuclear transition metal complexes' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Understanding, on a molecular level, how genetic information is expressed and how to stimulate or prevent this process is a key step towards the development of new chemotherapeutic strategies. In this framework, dimine transition metal complexes present particularly well-suited photophysical properties to develop new DNA photoprobes. Dinuclear iron (II) and ruthenium (II) complexes have been recently shown to interact very strongly within the DNA grooves and are probably the most promising candidates for such applications. The aim of the project is to deepen the knowledge about the photophysical properties and the interaction with DNA of this class of compounds. More precisely, sequence-selective recognition will be explored through fictionalization of their ligands. Two complementary research approaches will be developed: 1. The in-depth study (including both thermodynamic and kinetic aspects) of the effects of fictionalization of these dinuclear complexes on their interaction with DNA, especially concerning sequence discrimination. 2. The detailed study of the photophysical properties of these fictionalized compounds (including energy and electron transfer between the metal centres) in solution and in the presence of DNA. In both cases, the combination of different powerful spectroscopic methods including linear dichroism and luminescence measurements will be used. Quantum mechanical calculations are also planned to support experimental results interpretation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DevelopIng STratEgies by integrating mitigatioN, aDaptation and participation to climate changE Risks' under Horizon Europe.

assistant: **Concept**

DISTENDER will provide integrated strategies by building a methodological framework that guide the integration of climate change (CC) adaptation and mitigation strategies through participatory approaches in ways that respond to the impacts and risks of climate change (CC), supported by quantitative and qualitative analysis that facilitates the understanding of interactions, synergies and trade-offs. Holistic approaches to mitigation and adaptation must be tailored to the context-specific situation and this requires a flexible and participatory planning process to ensure legitimate and salient action, carried out by all important stakeholders. DISTENDER will develop a set of multi-driver qualitative and quantitative socio-economic-climate scenarios through a facilitated participatory process that integrates bottom-up knowledge and locally-relevant drivers with top-down information from the global European Shared Socioeconomic Pathways (SSPs) and downscaled Representative Concentration Pathways (RCPs) from IPCC. A cross-sectorial and multi-scale impact assessment modelling toolkit will be developed to analyse the complex interactions over multiple sectors, including an economic evaluation framework. The economic impact of the different efforts will be analyse, including damage claim settlement and how do sectoral activity patterns change under various scenarios considering indirect and cascading effects. It is an innovative project combining three key concepts: cross-scale, integration/harmonization and robustness checking. DISTENDER will follow a pragmatic approach applying methodologies and toolkits across a range of European case studies (six core case studies and five followers) that reflect a cross-section of the challenges posed by CC adaptation and mitigation. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Insoles for Neuropathy and Balance Issues'.

assistant: **Objectives**

An aging population and diseases related to aging (Parkinson’s disease, diabetes, neuropathy) increase feet numbness, balance and mobility issues. Affected people stop feeling the ground properly, which makes them lose balance and increases the risk of falls and injuries, which in turn lead to devastating consequences. Patients and families lose their independence and public healthcare costs are rising as a result – now the European population aged 65+ uses 60% of healthcare resources. One of the ways to reduce the costs of care for the elderly and chronic patients relates to fall prevention.At Walk With Path we invented Path Feel – an insole that provides vibrational feedback to the feet in real time to help people feel the ground again. It increased the balance and mobility of 92% of users and reduces their risk of falls by 50%. We have proven that it works in number of pre-clinical studies.  By bringing mobility back, Path Feel gives more freedom to the patient and the family.Within the project we will finish our existing prototype, validate it, certify, and introduce it to the market after the project ends.The elderly population in the EU is projected to increase, reaching 75 million in 2020 and 88 million in 2030. Over 220 million people worldwide suffer from balance and sensory issues, and the global walking aids market is estimated to surpass €1 billion by 2023, growing at an estimated CAGR of 4.3% from 2018 to 2023.We work with patient organizations and key opinion leaders to introduce the product to the market. We have multiple distribution agreements across the world (EU, Asia, America) and work with global shoe and insole manufacturers. We have already commercialized our first innovative product in the mobility sector – for patients with Parkinson’s disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Demonstration that bacterial polyesters are as reliable as the well proven polystyrene in analytical test systems' to be submitted under Fourth Framework.

assistant: **Abstract**

To demonstrate that ecologically friendly bacterial polyesters made from renewable resources are as reliable as the well proven polystyrene matrices in analytical test kits a producer of bacterial polyesters, a producer of disposable plastics and three different testing laboratories have joined to produce test carriers and kits and to prove on a large scale the usefulness, reliability, and reproducibility of the fermentation products in comparison to the hitherto used polystyrene. The project aims to convince laboratory personnel that disposable plastics made of environmentally friendly materials, especially plastics used for ELISA-tests, are as safe as conventional plastics and that no compromise in quality, sensitivity, or reproducibility is to be feared.  The project is based on laboratory developments showing that certain formulations of PHB (polyhydroxybutyric acid) and PLA (polylactic acid) bind antigens and antibodies equally well as polystyrene. Neither the laboratory developments nor the fermentation/compounding/moulding procedures need further basic research. However in order to convince testing labs that the new materials are as reliable as the hitherto used polystyrene it will be necessary to demonstrate that lot to lot quality is assured and that testing has been done on a large scale with multiple antigens and antibodies.  To this goal it is planned 1) to fine-tune the current industrial fermentation and extraction procedures used for the production of injection moulding grades to get materials with constant protein affinities, 2) to optimise blending/compounding of the fermented and extracted materials to the needs of the specific application, 3) to adapt present injection moulding procedures to the new applications, and 4) to thoroughly test the material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An integrated setup for in-vitro optogenetic experiments using AI to localize stimulation with a feedback of electrophysiological signals' to be submitted under Horizon 2020.

assistant: **Abstract**

The study of the brain remains one of the most challenging topics in science. A full understanding of the neuronal dynamics inside a living brain is still far from being achieved. Neuroscience tackles this problem by studying the neuronal functionality as individuals and in networks. For this purpose, different disciplines and approaches are used, e.g. electrophysiology, biochemistry, optogenetics and more. In this project I aim to provide an integrated experimental platform, which will assist in the study of the structure and the functionality of neuronal networks. The setup proposed in this project will serve as an optogenetic tool for in-vitro experiments, controlled by a feedback from electrophysiological signals from the network to address specific neuronal circuits. The control system will be trained by Deep-Learning techniques to localize the stimulation at specific neurons of interest.


**Keywords:** Biophysical techniques, Nanotools, Computational photonics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stimulating, Encouraging and Facilitating the Participation of Hungarian and Polish Surface Transport Research Organisations To FP6' under FP6.

assistant: **Concept**

The HUNPOL-Trans project proposes a coherent action plan for increasing Hungarian and Polish participation in FP6 in the surface transport sector. The activities planned also contribute to the creation of ERA by facilitating the Hungarian and Polish research potential wider cooperation within FP6 initiatives as well as other ways of cooperation between other ACC as well as Member States and third countries. The plan of HUNPOL-Trans will also renew enthusiasm in science and research for the surface transport all over Europe. WP1 is concerned with the identification of science and research institutions with a different R&D component that can improve implementation of FP6 relating to the surface transport. This identification will cover broad spectrum of products and technologies as well as different offers as to have broader view as to the whole Hungarian and Polish potential in surface transport. These institutions are classified in a database (WP4) that can be used during various tasks of the project to either disseminate information such as calls for proposals launched by the Commission or a running project, the workshops and activities organized in the project (WP3) and assessed by the Expert Groups (WP6). WP 2 is about providing a service to projects in gestation and projects that are running. WP 5 relates to the identification of young research potential in surface transport. All activities will be coordinated according to WP7 being in charge for the high quality of deliverables of the whole project. The European R&D associations for the road (EUCAR), rail (UNIFE & ERRAC) and maritime (COREDES) sectors are associated to the project on the basis that they or their members are going to be invited to strategic activities of the project (like brokerage events) as well a