RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demonstration of a synthetic biology-driven biomanufacturing platform for adaptable cost-effective production of high-value low volume biologics opportunities.' (SYNBIOMAN).

assistant: **Innovation**

Ingenza will address an unmet industry need at the European level for an enabling biologics manufacturing and refinement platform targeting difficult-to-express protein structures and/or hard-to-handle potent products that requires novel, efficient, low volume manufacturing.  This is a niche high-value market but the customisation and flexibility needed to address such complexity means the market is not of interest to larger established Contract Development Manufacturing Organisations.  Ingenza will deliver and demonstrate a novel synthetic biology (SynBio) driven manufacturing platform that is EMA and FDA certified for GMP production of investigational and commercial biologics.  This includes transitioning SynBio tools developed for industrial biotechnology towards addressing opportunities in the growing biopharmaceutical sector (CAGR 9.5%); delivering innovative biomanufacturing capabilities beyond the current state-of-the-art.  To achieve this goal Ingenza will deploy its inABLE® suite of proprietary SynBio tools including those for high throughput gene cloning, efficient strain screening/construction and effective bioprocess development - all integrated with state of the art single use biofermentors and downstream process technologies.  Ingenza’s biomanufacturing process is at TRL 6 moving towards TRL 9.  The project is supported by five novel biologics developers in the EU and US, one of which will provide the case study at Phase 2 using an microbial cell factory.  The Phase 1 project aims to (i) define the activities required to achieve Good Manufacturing Practice compliance for a first highly potent target biologic, (ii) demonstrate scale up, (iii) test the market to ensure a robust business model and (iv) confirm freedom to operate.  Ingenza expect to reach the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Ultrafast Dynamics using ATTosecond and XUV Free Electron Laser Sources'.

assistant: **Objectives**

Worldwide there is great excitement about two new ultrafast XUV/x-ray sources that are presently coming available. Attosecond XUV pulses by high-harmonic generation (HHG) will now allow for the first time to “make movies” of ultrafast electron motion, and thereby to investigate photo-chemical processes beyond the Born-Oppenheimer limit. At the same time, XUV/x-ray Free Electron Lasers (FELs) based on self-amplification of spontaneous emission (SASE) of relativistic electrons moving through an undulator structure will allow for the first time to track structural changes in (bio-)molecules using femtosecond time-resolved x-ray diffraction. In this context, the objectives of ATTOFEL are six-fold: 1) by establishing a framework for collaborative research on attosecond science, the potential is created for major breakthroughs in our understanding of the role of ultrafast electron dynamics in atomic physics, molecular physics and materials science. 2) by bringing together groups who recently have combined research in attosecond science with research efforts at the FLASH-FEL in Hamburg, an effective channel is created for knowledge transfer between the HHG/attosecond laser community and the FEL-community, which have historically been separate. 3) a generation of young scientists is trained that can shape the future of attosecond and FEL science, or that can embark on successful careers in industry. 4) the competitive advantage that European attosecond science and European XUV/x-ray FEL facilities currently have is significantly aided. 5) the competitive position of European industrial partners in the very demanding high-end ultrafast lasers market is strengthened. 6) the structuring of the international research community in this field will be consolidated, strengthened and ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In vivo metabolic determinants of T cell aging trajectories' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

T lymphocytes play a central role in the immune defense against intruders, and support tissue homeostasis and function. Strikingly, an aged or dysfunctional T cell immunity is sufficient to promote organ aging and multiple age-related morbidities.  In this proposal we hypothesize that there is a bidirectional relationship between T cells and their in vivo microenvironment that could develop into a vicious cycle under conditions of aging and disease. While a lot is known about the cellular mechanisms underlying T cell dysfunction with age, A profound understanding of how aging of the microenvironment impacts T cell immunity is missing. This work directly targets this gap to determine how the in vivo microenvironment in an aged mouse dictates T cells aging trajectories. Following on our preliminary findings, we will study two major mechanisms: (1) deficient metabolic support: we propose novel mechanisms by which stromal cells in the T cell zone of secondary lymphoid organs provide T cells metabolic needs for activation, and its failure in aged lymph nodes; and (2) toxic signals specific to the aged spleen that inhibit T cell metabolism and activation. Finally, we will investigate whether targeting these pathways would rejuvenate T cell immunity in vivo. The proposed study will discover unknown mechanisms supporting T cells metabolism in situ and will provide a causative link between T cell aging phenotypes and aging of their microenvironment. Finding new ways to rejuvenate immunity holds the promise for comprehensive and simultaneous targeting of multiple age-related pathologies.


**Keywords:** immunometabolism, immune aging, T lymphocytes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Quantum Photonic Engineering' (QPE) targeting Horizon 2020.

assistant: **Abstract**

By harnessing the unique properties of quantum mechanics (superposition and entanglement) to encode, transmit and process information, quantum information science offers significant opportunities to revolutionise information and communication technologies. The far-reaching goal of this project is to build quantum technology demonstrators that can outperform conventional technologies in communications and computation. For quantum information technologies (QITs) to have as big an impact on society as anticipated, a practical and scalable approach is needed. One promising approach to QITs is the photonics implementation, where single particles of light (photons) are used to encode, transmit and process quantum information – in the form of photonic quantum-bits (qubits). Currently, state-of-the-art experiments are limited to the “few-photon” regime, occupying many metres of space on an optical table, constructed from bulk optical elements, with no routes to scalability and far from outperforming conventional technologies. Integrated quantum photonics has recently emerged as a new approach to address these challenges. This research programme will take an engineering approach to QITs and draw upon rapidly growing field of silicon photonics. We will develop a silicon-based quantum technology platform where single-photon sources, circuits and detectors will be integrated into miniature microchip circuits containing thousands of discrete components, enabling breakthroughs in quantum communications and computation, and developing a scalable approach to quantum technologies.There are no new physics breakthroughs required to achieve the goals of this project, however, there are hard engineering challenges that need to be addressed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing & piloting biodiversity footprinting & natural capital accounting via a 'beehive' of sectoral hubs, for sustainable transition to a circular EU bioeconomy' in the context of a Horizon Europe call.

assistant: **Objectives**

Biodiversity is the true driving force of a sustainable, circular bioeconomy (CBE). While the CBE needs advanced technology and innovation to succeed, biodiversity determines the capacity of biological systems to adapt and evolve. For this reason, biodiversity considerations need to be reflected in economic practices and valuation. CircHive will measure and integrate the value of nature into public and business decision making by: 1) improving data availability, accessibility, and harmonisation; 2) developing a standardised method for biodiversity footprinting (BF) and integrating it with natural capital accounting (NCA); 3) mainstreaming the use of BF and NCA in public and private decision making, incl. improving disclosure, risk management, and investment practice; 4) testing and improving the developed methods and models; and 5) building a wider community ‘BEEHive’ for peer support and exploitation of results. A strong emphasis is put developing scientifically robust and standardised methods that bridge BF (life cycle analyses) and NCA (bookkeeping), given their multiple overlaps but also divergences that hinder operationalisation and uptake. An equally strong emphasis is placed on practice-testing to understand current practices and opportunities for further mainstreaming of biodiversity and natural capital into disclosure, ecolabelling, and investment decisions. Transitioning theory to practice is put to the test via a case study network who will apply different biodiversity-centric approaches in real life. This is carried out in sectoral case study hubs (industry, retailers, investors, cities) for peer learning and capacity building. In CircHive’s approach, CBE and biodiversity reinforce each other as a basis for resources and inspiration for sustainable business
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Objective testing equipment for vertical spray distribution measurement and integrated prediction software' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The voluntary testing of agricultural spray equipment is gradually becoming mandatory throughout Europe. For field crop sprayers without air assistance, the measuring and testing methodology is already standardised to a large extent. For air assisted sprayers, the present test methodologies are under discussion, especially those for testing the vertical spray distribution. Having the means to reliably measure this distribution in a cost effective procedure is the main bottleneck. Comparative research has shown that the measuring methodology is at present not sufficiently reliable in relation to field trials. Proper calibration on the sprayers however is very important in effective, low drift crop protection. The submitted proposal calls for the development of accurate measuring equipment that can solve the aforementioned problems and that can contribute to the implementation of the testing procedures for air assisted sprayers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cosmology, Astronomy, and Religion in Medieval India' under Horizon 2020.

assistant: **Concept**

CARMI proposes to study the friction between two cosmologies found in India in medieval times: the cosmological model used by the astronomical tradition of India, and the cosmology found in the Purāṇas, a group of texts sacred in Hinduism.In the Indian tradition, cosmology falls within the branch of knowledge known as jyotiḥśāstra, which has three divisions: saṃhitā (omens); horā (astrology); and gaṇita (the astral sciences, including astronomy and cosmology).With CARMI present, the Department of Cross-Cultural and Regional Studies will have experts in all three divisions, creating a unique research environment for the study of all aspects of jyotiḥśāstra. This will be particularly valuable for CARMI.Historically, the Indian astronomers rejected elements from the Purāṇas contradicting their model, but also incorporated compatible elements. With the astronomer Jñānarāja (1500 CE), this changed; he sought to create a synthesis between the two incompatible cosmologies. He maintained that the sacred Purāṇas could not be contradicted. At the same time, he needed a working science. So he re-interpreted passages from the Purāṇas. This approach had a significant impact on Indian astronomy.What were the dynamics that led to this approach? Why was it felt necessary to assert the authority of the Purāṇas within the Indian astronomical tradition?Through a careful investigation of Jñānarāja's sources, CARMI will have an interdisciplinary approach to the understanding of issues arising from the interaction of cosmology, on the one hand, and religion, on the other (that is, two separate subfields of Indology), in medieval India (ca. 1200 to 1500 CE) based on the analysis of primary Sanskrit sources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Institutional Activism in Corporate Governance: Qualified Foreign Institutional Investors in China' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Qualified Foreign Institutional Investors (QFIIs) potentially import practices of shareholder activism that can improve corporate governance in emerging economies’ stock markets. This proposal will scrutinize this proposition in the context of China. To do this, it explores the impact of QFIIs’ institutional activism, especially European QFIIs, on corporate governance in Chinese listed companies both in theory and in practice using the interdisciplinary methods of an economic analysis of law and quantitative analysis. The first objective is to conduct a theoretical analysis on the motivations behind QFIIs’ investments and their behavior as shareholders, supported by an analysis of data on companies targeted by QFIIs between 2003 and 2015. The aim is to find out whether QFIIs engage in shareholder activism in corporate China, especially following Chinese policy changes in relation to the regulation of QFIIs in 2006 and 2012. The Second objective is to conduct an empirical study by way of event study and multiple regression on the correlation between QFIIs stock-targeting/stockholding and the performance of Chinese listed companies over the same period, in order to identify the effectiveness of QFIIs’ institutional activism in improving corporate governance in Chinese listed companies. The working hypothesis of this proposal is that QFIIs may not engage in activism because of the speculative nature of institutional investors, and therefore that policy changes of 2006 and 2012 may not have enhanced QFIIs’ activism in corporate China. This suggests that further policy changes may be required, both in China and in Europe, if QFIIs are to engage in activism which benefits both China and their end beneficiaries. An appropriate set of policy recommendations will be identified a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'BioProtect Paper: Off-line machine for advanced bio-coating paper'.

assistant: **Concept**

The barrier resistance and wettability of papers are commonly controlled by the application of petroleum- based derivatives such as polyethylene, waxes and/or fluor- derivatives as standard coatings for the industry. While surface hydrophobicity is improved by employing these polymers, they have become disfavoured due to poor recyclability limitations, and environmental concerns on generated waste with lack of biodegradation. Contrary to popular opinion, most coffee cups and similar disposables still aren’t recyclable! With all the attention over the past decade on recycling and doing right by the environment, the lowly coffee cup appears to have been missed in the push to make every form of packaging reusable or recyclable. Roughly 200 billion paper cups are used around the world every year, but none of those currently in use can be recycled without incurring prohibitive costs or greatly diminishing the At ORLOGA, we have developed an off-line machine for the smooth and versatile industrial implementation of a protective coating for paper/cardboard with +100% resistance to water and fully recyclable. BioProtect Paper project is a simple, rapid, and efficient hydrophobization of cellulose fibers through their reaction with gaseous TCMS at mild conditions (solvent-free + room temperature + no drying required). The off-line machine can be implemented at different stages of the value chain. Hence, paper mills, paper processors or even stand-alone business cases can be generated to transform standard jumbo rolls into waterproof jumbo rolls to deliver added value for the final paper processors. Th final products, being paper cups, specialty papers or other paper/cardboard packaging materials will continue with the recyclability of the initial jumbo roll. BPP reduces x1.5 the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Infinite Protein Self-Assembly in Health and Disease'.

assistant: **Concept**

Understanding how proteins respond to mutations is of paramount importance to biology and disease. While protein stability and misfolding have been instrumental in rationalizing the impact of mutations, we recently discovered that an alternative route is also frequent, where mutations at the surface of symmetric proteins trigger novel self-interactions that lead to infinite self-assembly. This mechanism can be involved in disease, as in sickle-cell anemia, but may also serve in adaptation. Importantly, it differs fundamentally from aggregation, because misfolding does not drive it. Thus, we term it “agglomeration”. The ease with which agglomeration can occur, even by single point mutations, shifts the paradigm of how quickly new protein assemblies can emerge, both in health and disease. This prompts us to determine the basic principles of protein agglomeration and explore its implications in cell physiology and human disease.We propose an interdisciplinary research program bridging atomic and cellular scales to explore agglomeration in three aims: (i) Map the landscape of protein agglomeration in response to mutation in endogenous yeast proteins; (ii) Characterize how yeast physiology impacts agglomeration by changes in gene expression or cell state, and, conversely, how protein agglomerates impact yeast fitness. (iii) Analyze agglomeration in relation to human disease via two approaches. First, by predicting single nucleotide polymorphisms that trigger agglomeration, prioritizing them using knowledge from Aims 1 & 2, and characterizing them experimentally. Second, by providing a proof-of-concept that agglomeration can be exploited in drug design, whereby drugs induce its formation, like mutations can do.Overall, through this research, we aim to establish agglomeration