RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Human Skin Microbiome Engineering' (HuSME).

assistant: **Innovation**

The skin microbiome constitutes an attractive platform to incorporate novel functionalities to the host, due to accessible location, tight contact with the host, low immunogenicity, and easier genetic manipulation, among other reasons. I will adopt a translational synthetic biology approach to engineer the human skin commensal C. acnes (formerly P. acnes) as a disease-sensing biological device (“biodevice”) with therapeutic activity. Precisely, engineered C. acnes will detect atopic dermatitis (AD, the most common chronic inflammatory disease worldwide) and respond by producing an anti-inflammatory molecule. First, I will develop a vector and a methodology for efficient gene delivery into C. acnes. Next, I will construct synthetic gene circuits that will allow C. acnes to detect inflammatory markers in vitro and to respond by secreting anti-inflammatory signals. Finally, I will use the C. acnes biodevice as an in vivo therapeutic product: I will apply the engineered bacteria on a mouse model of AD and evaluate its potential as a therapeutic tool capable of disease-sensing and regulated maintenance of skin homeostasis. This project will contribute to the emerging field of human microbiome genetic engineering, will inspire and guide future efforts towards microbiome repurposing for therapeutics, and has the potential to provide exploitable results and better therapeutic options for AD patients.


**Keywords:** translational synthetic biology, ""smart"" engineered bacteria, programmable probiotics, human skin microbiome engineering, skin microbiome, C. acnes, P. acnes, gene circuit, atopic dermatitis""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Mechanisms for the selective clearance of chemically damaged proteins in mammalian cells' (PRO-CLEAR) targeting Horizon 2020.

assistant: **Abstract**

Cellular homeostasis and survival critically depend on the ability to remove misfolded and damaged proteins. In cells, proteins are continuously exposed to reactive metabolites which introduce modifications such as oxidation, carbonylation, glycation or carbamylation. Such non-enzymatic post-translational modifications (nePTM) can irreversibly block critical interaction surfaces or reactive sites and thus pose a constant threat to proteome integrity. In line with this view, levels of nePTM are increased in diseased and aged tissues. In contrast, nePTM-bearing proteins are selectively degraded in healthy cells, suggesting the existence of a so far unknown pathway that recognizes and eliminates nePTM-bearing proteins.In this project, I will study the impact of nePTMs on protein turnover and explore the underlying molecular mechanisms. More specifically, I plan to (I) establish a reporter assay to monitor the degradation of proteins displaying individual amino acid modifications in human cells. This will allow to test effects of common nePTMs and to identify the precise chemical adducts that induce protein clearance. Aim (II) is to uncover the cellular machinery that mediates nePTM-triggered protein degradation. To this end, I will perform a genome-wide CRISPR screen for genes required to eliminate a fluorescent model substrate. Aim (III) of the project is to understand the mechanisms underlying the recognition and clearance of nePTMs. I will therefore characterize one newly identified mediator of nePTM-clearance in detail and test its ability to bind, degrade or modify nePTM-bearing proteins and will study the impact of its knockout on the turnover of endogenous proteins.Together these experiments promise to uncover a novel pathway for the quality control of chemically da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Earthquake mechanics, Earth structure and related problems' (1998-2002) under Fifth Framework.

assistant: **Objectives**

We propose an interdisciplinary EuroConference focussed on two main aspects of Seismology, namely, the mechanics of the faulting process of earthquakes, and the structure of the Earth. For many years scientists in separate fields have been working on these problems from different points of view, namely, theoretical, observational, and laboratory experimental ones. At the beginning of the new millennium, it is a propitious time to bring together all these scientists from many countries to review the state-of-the-art at the cutting edge of research in this area and to consider future lines of development. Scientists from as varied subject areas as fracture mechanics, mathematics, seismology, earthquake engineering as well as from industry will be invited to participate.In addition to the list of distinguished core group of speakers, wide participation of younger scientists and their interaction with more established researchers will be a key feature of this conference. The aim is a comprehensive examination from theoretical, observational and laboratory view points of where the subject has been, where it is today, and where it is going (i.e. some review papers, some state-of-the-art papers and some discussions on what are the unsolved problems and what can we do to solve them). The conference will be divided into five sessions: A: From laboratory experiments to earthquake dynamics; B: Generation of seismic waves and earthquake source; C: Deep focus earthquakes; D: Earth structure and seismic wave modelling; E: Earthquake damage and prediction of strong ground motion. The major part of the meeting will be devoted to the subject of earthquakes and related problems, but since the waves from the earthquake travel through the Earth, the Earth structure must also be considered
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The Integrated Initiative of European Laser Research Infrastructures II' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

LASERLAB-EUROPE II is a Consortium of Laser Research Infrastructures from the majority of the European member states, forming a FP7 Integrated Infrastructure Initiative. Given the importance of lasers and their applications in all areas of sciences, life sciences and technologies, the main objectives of the Consortium are: - To form a competitive, inter-disciplinary network of European national laser laboratories; - To strengthen the European leading role in laser research through Joint Research Activities (JRA), pushing the laser concept into new directions and opening up new applications of key importance; - To engage in the Transnational Access Programme in a co-ordinated fashion for the benefit of the European research community. - To increase the European basis in laser research and applications by reaching out to neighboring scientific communities and by assisting the development of Laser Research Infrastructures on both the national and the European level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Sharing Age A Sharing Approach to Promoting Science'.

assistant: **Objectives**

Although the EU has been funding superb health research, the general public who stand to benefit most, are frequently unaware of the research that is conducted on their behalf. Communications are becoming more social, digital and interactive. We propose a Sharing Approach to Promoting Science (ASAPS) that sets us apart from others because we aim to engage our audience from the outset and embed them in the creation of idea and content. We will use digital technologies, social media, user-experience design,  and multiplatform story telling to increase the visibility of collaborative Europe wide aging research and technology development, that has real relevance for the general public.  One of the primary ways in which older adults use the internet is to educate themselves regarding their health. We will deliver a sustainable digital platform, an interactive website, a multi-lingual package of films (3 viral films, 3 shorts, a 60 minute documentary), mobile apps, events and to address the digital divide more traditional media. Our approach is innovative and our consortium comprising, aging experts, world class scientists, a European network representing 160 ageing organizations with access to 28 million people over 50, award winning media professionals including a creative communications agency, a digital design company (specialists in interaction design for social web) and an award-winning factual film production are perfectly qualified to deliver our innovative Sharing Age campaign.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Developing a novel light-weight Ready Mixed Concrete' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Ordinary ready-mixed concrete is made of sand, cement, water, stone gravel and additives. Albeit aggregate gravel is chosen for its high compressive strength and relatively low cost, its use is associated with different problems. Due to its high density, any construction will require more steel reinforcement to support the weight of the heavy concrete. The different sizes and shapes as well as the inconsistent distribution of the gravel causes air and water voids, causing weak points and is responsible for crack propagation in the concrete structure. Despite technical problems, the usage of gravel is also responsible for significant amounts of quarrying, transportation costs and CO2 emissions. We have innovated and developed a novel process and a system (consisting of the GEM-TECHTM machine and GEM-SOLTM catalyst) that creates a ‘superior foam’, which does not drain off for at least 12 hours, providing sufficient time for the cement to set resulting in high compressive strengths. The geodesic structure that is created by the novel mixing screw action and the ingredients that are mixed systematically in the GEM-TECHTM machine without using any gravel or any admixtures into GEM-TECHTM ready-mixed material provide significant cost savings. The main objectives of the ReMix project is to investigate the feasibility of developing different size machines with different specifications, examine the commercial and technical risks of the process, develop strategies to meet different standard requirements and develop strategies to commerialise our unique product.  The overall objective is to develop an advanced ready mixed concrete replacement material, which is at least 45% cheaper, 28% lighter, with high compressive and flexural strengths. Our main goal is to establish GEM-TECH t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reconstructing dinosaur/bird locomotor evolution: 3-D track simulation and X-ray validation' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The evolution of birds from their dinosaur ancestors represents one of the most important and widely used examples of evolution available from the fossil record.  Within this dinosaur-bird lineage, the evolution of bipedal locomotion has proven to be an intensely active area of research.  Most of this research has taken an almost exclusively osteological approach, but while the fossilised skeletons of extinct animals can tell us much about their anatomy and palaeobiology, it is fossilised tracks that represent our only direct record of limb kinematics and animal locomotion.A fossil track represents the only direct record of limb motion, being the result of an interaction between an animal’s foot and a substrate.  Track morphology is completely determined by substrate consistency, limb kinematics and kinetics, and foot morphology.  By reverse engineering the process of track formation, information can be obtained pertaining to the locomotion of the track maker.The proposed research aims to investigate the effects of differing limb motion on track formation, in an attempt to understand locomotor evolution throughout the 230 million year evolutionary history of theropods (including modern birds). This will be achieved by marshalling state-of-the-art methods including bi-planer x-ray visualisation in order to physically model tracks.  A virtual ‘track simulator,’ based on the discrete element method for modelling granular substrates will then be developed to explore in detail the effects limb motion has upon track formation.  This knowledge will then be applied to the fossil record to observe any changes attributable to limb kinematics and locomotor evolution through time.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Openmath-accessing and using mathematical information electronically'.

assistant: **Objectives**

The primary objective of this project is to develop the technology to allow mathematics to be displayed in a meaningful way in modern multimedia computing environments.The vehicle for achieving this and the principal result of the project will be the OpenMath Standard which will define a framework within which diverse software packages ranging from web browsers to electronic books can exchange semantically-rich representations of mathematical objects. The standard will do two principal things: it will lay down rules for the representation of such objects; and it will define the architecture that a piece of software has to adopt to be 'OpenMath-compliant'. To have a chance of being adopted widely, such a standard has to satisfy the following essential criteria: 1. It must not be biased towards any one particular application or software package. 2. It must be reasonably efficient. 3. It must be easily extensible. 4. It must allow interactions with other widely-used encodings (in this case LATEX and SGML/HTML). The project intends to demonstrate that the OpenMath standard has these qualities through a series of prototypes involving mathematical software, electronic books and texts, and the world wide web. This prototyping and development activity will feed back into the definition of the standard, ensuring that it is usable in practice. The ultimate objective for the project is to have OpenMath adopted by a suitable international standardisation body. Members of the Consortium are involved in related work in ISO (Mathematics subgroup of Working Group SC4/WG6) and the World Wide Web Consortium (the HTML-Math Working Group) and it is by these bodies that we hope to have OpenMath adopted.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Large-scale platform for motion detection and fluorescence imaging in zebrafish models of neurological disorders' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The PhenoTECH project aims to develop a novel technology with high-throughput capacity for screening and phenotyping of genetic models of disease. PhenoTECH will enable an unprecedented capability to monitor and control multiple parameters that will significantly contribute to advancing fundamental and biopharmaceutical research, strongly accelerating discovery of novel treatments for debilitating neurodegenerative diseases. PhenoTECH’s immediate impact will be on the ERC Consolidator Grant, ALS-Networks, where we intend to utilize the power of zebrafish for high-throughput functional screens to uncover defective cellular pathways and to identify therapeutic targets for ALS and related neurodegenerative disorders. High-throughput phenotype-based screening efforts have until now been hampered by the lack of technology that would allow for parallel monitoring of behavioral, cellular and physiological markers of disease. To overcome this limitation, PhenoTECH will build an innovative platform for automated phenotypic analysis consisting of three modules: i) custom designed multiwell plates with the capacity for in-well perfusion of solutions, greatly facilitating and optimizing drug delivery, wash-out, temperature and oxygenation control;  ii) state of the art motion (motor) tracking with analysis of spontaneous and evoked locomotion of zebrafish larvae; iii) fluorescence detection of genetically-encoded transgenic line reporters to enable live monitoring and imaging of cellular processes and neuronal activity. By combining these three capabilities, PhenoTECH will surpass any existing commercial product on the market and will enable low-cost, large-scale screening capability for development of efficient treatments to neurodegenerative diseases. PhenoTECH will have a strong
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Transmission and Transformation of Texts in the Tarim Basin: a corpus approach' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ""Transmission and Transformation of Texts in the Tarim Basin: a corpus approach"" project (4TB) is designed to contribute to the study of three prominent languages of the pre-Islamic Tarim Basin (in todays Xinjiang Uygur Autonomous Region in the Peoples Republic of China): Tocharian A, Old Uyghur, and Sanskrit. The innovation part of this contribution assumes creating a comprehensive parallel text corpus of Buddhist texts in the said languages, an open-access digital tool for linguistic and philological study. The research part assumes analyzing details and searching for patterns of transmission and transformation of those Buddhist texts, from Sanskrit to Tocharian A, from Tocharian A to Old Uyghur. This is going to be achieved by answering the following research questions: 1) What are the linguistic patterns of transmission and transformation of the discussed texts? 2) How were the discussed texts transmitted and transformed from the philological point of view?The results of my action will substantially facilitate cross-linguistic studies for scholars of three language groups. Also, they will have an interdisciplinary impact, bringing a large amount of textual information to non-linguist researchers, e.g., scholars of Buddhism and historians. Moreover, my action has a potential for further research, as it can later include other adjacent languages. The host institution will be University of Vienna. My supervisor will be Hannes Fellner, one of the key developers of the CEToM project (the Tocharian A and B text corpus) and the lead of the Tarim Brahmi project. His experience in Digital Humanities and the Tocharian studies will be extremely helpful for my research.""


**Keywords:** digital humanities,  Tarim Basin studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Design Study for a Muon Collider complex at 10+ TeV center of mass' (MuCol) targeting Horizon Europe.

assistant: **Abstract**

Two facility concepts have been considered as potential pathways to the future of particle physics at the energy frontier in Europe: FCC-hh, a 100 TeV circular hadron collider and CLIC, a 3 TeV linear lepton (i.e. electron-positron) collider.The recent European Accelerator R&D Roadmap includes a novel option, a 10 or more TeV muon collider, which expands the lepton collider energy reach and promises compact dimensions, high efficiency and limited cost.Muons are point-like particles, in contrast to hadrons; a 10 TeV muon collider would have a comparable physics case, for a number of physics processes, to a 100 TeV hadron collider.The muon collider promises high benefit but also faces a significant risk, as it is the first of its kind and uses novel advanced technologies.The MuCol design study will address the core challenges identified in the Roadmap, develop the concept and technologies and demonstrate:•the physics case of the muon collider is sound and detector systems can yield sufficient resolution and rejection of backgrounds;•no principle technological issues will prevent the achievement of a satisfactory performance of the accelerator or the detectors;•the muon collider provides a highly sustainable energy frontier facility compared to other equivalent colliders; and•exploiting synergies with other scientific and industrial R&D projects, can provide Europe a leading edge in discovery potential and development of associated technologies.The final report will include a thorough assessment of benefits and risks of the accelerator and detector complex, including an evaluation of the scientific, industrial and societal return beyond high-energy physics, the cost scale and sustainability of the complex and the impact arising from an implementation on the CERN site. This