RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Best practice for information technology in the textile industry' (BIT).

assistant: **Concept**

The objective of BIT is to stimulate the use of best practice techniques to aid SMEs in the textile industry to adopt and implement effectively advanced, integrated IT systems. The focus of the project will be the integration of various types of IT systems.BIT covers all aspects of an SMEs business process from electronic commerce between trading partners to the integration of various aspects of the SMEs manufacturing processes.The business objectives of BIT are to enhance the effects of system applications on an SMEs flexibility and competitiveness. This will be achieved by improved integration levels between various types of systems.The consortium comprises textile SMEs in the UK, Denmark and Greece.The approach will be as follows:- to identify the detailed nature of the business requirements for the companies within the consortium- to identify the IT systems which provide the best solutions to the requirements identified together with the resulting interaction requirements. During this stage, systems resulting from previous EU projects will be evaluated. These include ESPRIT projects EP5478, EP2277, EP5246 and the EUREKA FORCAST project, covering the areas of scheduling, EDI and integration. Since systems from normal commercial routes will also be evaluated, it will be possible to submit proposals to the EU aimed at increasing the commercial potential of EU projects. These recommendations may include areas such as the functionality of the systems and also support issues which may have an impact on the practical commercial take-up of such systems.- assistance will then be given to help ensure that the most effective system is selected and implemented in accordance with the principles of Best Practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Enhanced sensitivity Nanotechnology-based Multiplexed Bioassay Platform for diagnostic applications' (NANO-MUBIOP).

assistant: **Innovation**

Currently, there is strong interest in the development of new bioassay techniques for gene identification, gene mapping, DNA sequencing and medical diagnostics. There are three main families of methods: Polymerase Chain Reaction, Enzyme-Linked Immunosorbent Assay and nano-particles agglutination techniques. All these methods suffer from several disadvantages as they are time-consuming and expensive, they are not quantitative and exclude multiplexing, i.e. the detection of different genotypes simultaneously. The need of a new multiplexing and quantitative bioassay technique is evident. The aim of this project is to develop a high sensitivity multiplexed platform based on a bio-non bio nanostructure able to enhance diagnostic capabilities by exploiting the dimensional shift from bio-systems to nanometric particles, thus overcoming many of the limitations of the existing methods. This method could be adapted to the detection of many kinds of bio-systems, but the project will focus on Human Papilloma Virus (HPV) responsible for cancer. The project idea is based on the development of nanoparticles functionalised with probes complementary to HPV DNA conservative region and an array of specific bio-probes for the different HPV genotypes deposited on a solid substrate. The nanoparticles will bind to the bio-system and then they will diffuse through the suspension docking to the area of the array where the probe specific for that genotype is coated. An array of nanoparticles will be created and the concentration of each HPV genotype can be quantified by estimating the number of particles bounded to each specific area. Considering the global worldwide market of the immune and genetic tests (20 Billion €) the potential economic impact can be up to 100 M€. Private/public national o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Cross-presentation of antigens by dendritic cells: mechanistic aspects of the cross-presentation of tumour specific antigens.'.

assistant: **Innovation**

In vivo, cross-presentation of exogenous antigens has mostly been associated with dendritic cells. This process, which does not depend on the degradation of newly synthesized proteins, allows for the acquisition and presentation of peptides derived from exogenous antigens on MHC class I molecules. Better understanding of the mechanism of cross-presentation is essential, first because it appears crucial for priming CD8-positive T cell responses, and second because it has implications for various issues such as transplantation, viral infection, vaccination, autoimmune diseases and cancer.   Recent reports have highlighted crucial aspects of the cellular mechanisms involved in cross-presentation. However, our understanding of this phenomenon remains incomplete. Here, we propose to study cross-presentation of exogenous antigens by confocal video microscopy and biochemical approaches, with a focus on the cross-presentation of tumour specific antigens of the MAGE-type.   This study will be realized through a collaboration between two partners: the laboratory of Pr Cresswell in the Section of Immunobiology in Yale University Medical School, and the Cellular Genetics Unit of the Christian de Duve Institute of Cellular Pathology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Educational virtual reality environment for collaborative learning and networked multimedia' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content significant impacts on important wetland functions (biodiversity, stability of river and lake margins, water quality) and local economies. EUREED II is a three-year strategic fundamental research initiative that aims at analyzing the mechanisms which control the growth dynamics and stability of reed-dominated ecosystems, at modelling and predicting how the ecosystem is disturbed by human activity and climate change, and at developing remedial management options. Expected achievements include (i)assessment of the functional role of reed-dominated ecotones as nutrient accumulators and transformers and as sources for atmospheric greenhouse gases, (ii) an ecosystem model capable of predicting future changes in ecosystem functioning in relation to climatic conditions, trophic status and water table management, (iii) assessment of genetic diversity of reed populations and its relation to die-back, and (iv) development of management tools, including preventative and restQrative measures in relation to die-back. The scientific approach of the workprogramme is multidisciplinary and co-operative, and comprises observational field studies, field experiments, controlled greenhouse and laboratory experiments, data collation and treatment, and mathematical modelling. A significant part of the studies is carried out during multidisciplinary workshops. The project is carried out by research groups with complementary skills and expertise from nine European countries. A reference site is selected in each country as the basis for the field studies. The reference sites cover boreal-mediterranean and oceanic-continental climatic gradients, and the observational and experimental studies at these sites permit interpolation between sites, extrapolation of result
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'LIGHTHOUSE: concentrated thermal solar power directly connected to the heating and cooling systems of buildings at the local level.'.

assistant: **Concept**

The idea of LIGHTHOUSE (patented) is pretty simple, we concentrate the solar power, as we used to do when we were playing as children, in order to transform the power of the sun into pure heat in high temperature and connect it,  to our building heating and/or cooling systems, and this way reduce the costs up to 60% and protect the environment at the same time. LIGHTHOUSE  brings the power of the big solar power plants at every building  at the local level, in a financially feasible way, allowing collection of solar energy at high temperatures, with excellent and reliable performance all year round, all day long, with maximum efficiency. Solar heating and cooling is a key player in the EU energy policy framework, especially towards achieving the 2020 targets, and European Energy Council describes the  heating and cooling need in buildings at the local level,  as a “Sleeping Giant”. LIGHTHOUSE primary target is to reduce the fossil fuels that are burned inside the cities, and the electricity consumed from the city’s grid, for heating and cooling our buildings (49% of the global energy consumption), much more efficient than any other solutions like photovoltaic or CPV which produces only electricity and not high quality thermal energy (heat that is needed for heating and cooling) . The aim of the feasibility study is to identify and select the best materials and components in terms of cost-effectiveness and availability, by means of a market research; then, the performance of the key parts  will be evaluated by testing several Fresnel lens (key component); in parallel, a study on the LIGHTHOUSE design will be carried out, taking into account issues like safety, durability, efficiency and aesthetics, together with cost-effectiveness. The systematic collection of results wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular wires as key components in nanoelectronic devices' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The aims of the project are (i) to investigate and model the mechanisms of molecular charge transport through pi-conjugated molecules and (ii) to prepare simple electronic devices such as diodes and transistors based on monolayers of these materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The Physics of Metal Plasticity'.

assistant: **Objectives**

The societal need to conserve materials and energy calls for lighter and stronger metal components. The advantage of metals is their unique combination of plasticity (i.e. formability) and strength, which is governed by their complex structure. This structure is organized hierarchically on several length scales. In contrast to functional materials and polymers, this complexity has led to the common theoretical framework being not physics, but an engineering science: metallurgy. As a result, phenomenological models prevail.The big obstacle to understand the underlying physics is the lack of visualization of the dynamics of the structure. From 2012 to 2019 I have developed a hard x-ray microscope for high-resolution 3D studies. Uniquely, this now allows us to zoom into the material and map grains and dislocations. This will enable 3D movies on all relevant length scales. No competing group will have anything similar within the next 5 years.PMP will exploit this to unravel the physics of plasticity. For the first time, we can directly see the processes involved: the creation of dislocations, their self-organization, and subsequent creation of ever more complex patterns. At the same time, we can deduce the local stress. This will provide answers to longstanding core questions of metal science.Current multiscale models of plasticity are not capable of predicting realistic patterns. The new data will guide theory and allow for direct comparison of models and experiment at all scales. PMP will develop a physics-based multiscale model of plasticity that for the first time can predict which patterns evolve when and where in the metal, and as a result greatly improve predictions of the macroscopic plasticity and strength.If successful, we have created the instrumental and modelli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From Simplicity to Complexity: Crafting Molecular Architectures via Cascade Polyene Cyclizations' under Horizon 2020.

assistant: **Concept**

Polyene cyclizations belong to the most powerful and fascinating chemical transformations to rapidly assemble molecular architectures. However, the very limited substitution pattern of known substrates and natures inability to accommodate heteroatoms or substituents other than methyl restrict molecular diversity, complexity and functionality. CRAFTMOL addresses these limitations by investigating a set of novel heteroatom-substituted and tri/tetrasubstituted polyenes. The participation of these structural units in the cyclization will unlock previously inaccessible reaction pathways and enable efficient, selective and practicable routes to anticancer, anti-inflammatory and antiviral molecules. We will first investigate substrates containing trisubstituted double bonds and explore their behavior in cyclizations involving a transannular/cross-termination step. Realization of this concept will provide a highly modular synthetic platform for the rapid construction of more than 15 bioactive natural products. For the second part, we will explore tetrasubstituted double bonds to realize first-time synthesis of a structurally diverse family of natural products with unique biological activities. We will accomplish these goals by taking advantage of our expertise in total synthesis of complex natural products and modern chemical methodology. The experiments will be guided by computational methods and supported by our high-pressure platform. CRAFTMOL is ground-breaking as it 1) unveils innovative reaction pathways, 2) provides efficient synthetic access to structurally diverse molecular architectures, 3) enables deep-seated structural modifications of natural molecules that are currently inaccessible via fermentation or semi-synthesis. CRAFTMOL will lead to a better understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Therapeutic angiogenesis for the treatment of diabetes-induced vascular complications' (1998-2002).

assistant: **Innovation**

The National Laboratory of the National Institute of Biostructures and Biosystems (INBB) is recruiting two scientists who will be engaged in:1) expanding manufacturing facility to provide pre-clinical grade adenovirus (AV), adeno-associated virus (AAV) and lentivirus (LV) vectors for novel gene therapy and2) harvesting, selecting and enriching endothelial cell progenitors from human peripheral blood. These individuals will be responsible for providing such vectors and cells that will be used to promote therapeutic angiogenesis in animal models of diabetes-induced microangiopathy and peripheral neuropathy. The scientist in charge of gene transfer systems will oversee ongoing viral production and implement new scale up and purification techniques for AAV, AV and other vectors suitable for human tissue kallikrein, NGF, and eNOS transgene delivery. The scientist in charge of endothelial cell progenitors will be responsible of isolation of CD34+ KDR+ cells from human blood in quantities sufficient for in vivo experiments in animal models. Both scientists will need experience in molecular biology, virology, and cell biology. For endothelial cell progenitor program, competence in hematology is required. Both positions require a PhD or at least 4-year post-graduate experience in the above areas. Interested individuals should send resumes to Paolo Madeddu, MD, Prof. of Therapy, Head of Gene Therapy Section of the National Laboratory INBB, Via S. Antonio, 07033 Osilo (SS), Italy. Tel/fax 0039 79 3441006, Email: madeddu@yahoo.com. INBB is a National Consortium of 26 Italian Universities with Laboratory facilities in Northern Sardinia.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An Analysis of Educational, Labor Market, Demographic and Health Outcomes of Syrian Refugees in Turkey' under Horizon 2020.

assistant: **Concept**

Turkey hosts the largest number of refugees worldwide. According to the Turkish Directorate General for Migration Management (TDGMM), 3.61 million Syrian refugees resided in Turkey as of August 2020. While studies examining the effect of refugees on natives’ outcomes have recently burgeoned both in the Turkish setting and elsewhere, we know very little about the Syrian refugees themselves— despite the massive size of this refugee influx. This is mostly due to the lack of representative datasets. A tremendous new opportunity comes up with the 2018 wave of Turkish Demographic and Health Survey (TDHS), which provides a representative sample of Syrian refugees based on a household screening procedure using the official registry records from the TDGMM. Using the representative and rich data provided by this dataset, the purpose of this project is to understand the key educational, labor market, demographic and health outcomes of Syrian refugees in Turkey. This project will significantly progress the research beyond the current state-of-art first by conducting a rigorous econometric analysis of key outcomes of the biggest refugee group in the world using a representative dataset for the first time, and second by uncovering the channels underlying the observed patterns in these outcomes. Particularly, this project will address four main topics: (i) schooling, (ii) employment and living conditions, (iii) marriage and fertility, (iv) infant and child health.


**Keywords:** Refugees,  education,  employment,  demography,  child health,  applied econometrics,  Demographic and Health Surveys,  Turkey,  Syria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Breakthrough Brain Stimulation Device for Epilepsy' (BFORE).

assistant: **Innovation**

EASEE® stands for epicranial application of stimulation electrodes in epilepsy. It is the first minimally invasive device for focal cortical stimulation. Based on the Laplace electrode (central electrode surrounded by a ring electrode), EASEE® features 4 distinct electrodes replacing the outer ring, connected to 4 independent current sources to account for impedance and anatomical variances in the human skull. Still, the characteristic quadrupolar local electric field with high penetration depth is maintained. The stimulation pattern is one of a kind. EASEE® is equipped for high frequency, DC-like, and low-frequency stimulation, depending on the condition to be treated. In epilepsy, intermittent high-frequency stimulation bursts throughout the day are combined with a 20min DC-like stimulation session. This first is meant to terminate upcoming seizures, the second to initiate neuromodulatory processes to down-regulate the overexcitability of the epileptic brain area.


**Keywords:** minimally invasive,Neurostimulation