RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'State Capacity, Development, Conflict, and Climate Change' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed research concerns two sets of issues. The first concerns the role of state building in the development process, and the role played by violent conflict whether internal or external to the state. In this research, we will build a sequence of theoretical models, taking a stepping stone in a basic framework where new infrastructure that expands the state s capacity to raise revenue and to support private markets is viewed as outcome of investments under uncertainty. Our objective in model building is to provide guidance for the collection of historical and contemporary data and for econometric testing, which will both be central to the project. The overall goal of this project is to bring the analysis of state capacity into the mainstream of economics, and thereby shed light on the complex interactions between state building, conflict and development. The second set of issues ultimately concerns the economics of climate change. A first subproject aims at estimating the historical effects of weather on infant mortality in Africa, using a variety of data sources: individual data based on retrospective DHS surveys, finely-gridded weather data based on so-called re-analyis with large-scale climate models, and spatial data on harvest times based on satellite data on plant growth. Exploiting the random component of historical weather fluctuation allows us to estimate causal effects on health outcomes via mechanisms like malnutrition and malaria. This initial research will serve as a pilot study, to develop a methodology for studying the weather impacts on any outcome of interest anywhere in the world. Eventually such estimates will serve to estimate the future costs of climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'CO-OPERATIVE HEALTH-INFORMATION-NETWORKS' in the context of a Fourth Framework call.

assistant: **Objectives**

CHIN establishes and promotes cooperation between regional information networks for comprehensive telematics-based health care services. The overall system will cover eight European regions, taking in both city and rural areas. It will be validated on the basis of feedback from users, including hospitals, clinics and doctors, as well as private individuals. Clients linked to CHIN will be able to call on technical facilities including desk-top video-conferencing and file transfer, and consider generic approaches suited to specific regions or services such as patient care management.The main objective of CHIN is to establish a network of regional Co-operative Health Information Networks (CHINs) which support comprehensive and integrated sets of Health Care Telematic (HCT) services for a broad range of users. This will be implemented in eight representative European regions, both rural and metropolitan, and a realistic validation of their benefits will be performed by measuring acceptance and usage of HCT services by representative user groups. The networks are being considered as crystallisation points for further enhancements.Technically a Network of Co-operative Health Information Networks within Europe will be set up. It consists of modular CHIN clients, linked to CHIN network servers, which are connected on a European level. The technical systems will integrate application and service components in a standard conforment, modular and scalable way. These services and applications are grouped into basic services - such as desk-top videoconferencing, file transfer, e-mail and application sharing, generic services such as security and generic solutions for region-specific services - and specific services - such as patient care management and healthcare education and online
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scanning probe microscopies for nanoscale fast, tomographic and composition imaging' in the context of a Horizon 2020 call.

assistant: **Objectives**

Advanced Microscopy techniques are widely recognized as one of the pillars onto which the research and manufacture of Nanotechnology based products is sustained. At present, the greatest challenge faced by these techniques is the realization of fast and non-destructive tomographic images with chemical composition sensitivity and with sub-10 nm spatial resolution, in both organic and inorganic materials, and in all environmental conditions. Scanning Probe Microscopes are currently the Advanced Microscopy techniques experiencing the fastest evolution and innovation towards solving this challenge. Scanning Probe Microscopes have crossed fundamental barriers, and novel systems exist that show potential unparalleled performance in terms of 3D nanoscale imaging capabilities, imaging speed and chemical sensitivity mapping. The objective of the SPM2.0 European Training Network is to train a new generation of researchers in the science and technology of these novel Scanning Probe Microscopes, in which Europe is currently in a leading position, in order to enforce its further development and its quick and wide commercialization and implementation in public and private research centers and industrial and metrology institutions. The researchers of the network will acquire a solid state-of-the-art multidisciplinary scientific training in this field of research, covering from basic science to industrial applications, which should enable them to generate new scientific knowledge of the highest impact. In addition, they will receive a practical training on transferable skills in order to increase their employability perspectives and to qualify them to access to responsibility job positions in the private and public sectors. The final aim of the network is to consolidate Europe as the w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'FRAME - tumor genome-based personalized anti-cancer vaccines off-the-shelf' (FRAME).

assistant: **Innovation**

Frame Cancer Therapeutics is a Dutch start-up that develops effective vaccines against cancer, based on frameshift mutations. Driven by the ambition to provide a therapeutic effect for up to 50% of all cancers, Frame aims to alter the status quo of cancer treatment. Our balanced team consists of top researchers and successful biotech entrepreneurs with a track record including the CEO of Crucell , and founder of ProQR. The clinical use of so-called checkpoint inhibitors, which activate the immune system, has shown great effects, particularly for treatment of advanced melanoma. Yet, a large group of cancer patients does not benefit from this treatment alone, and the next step is to combine this general activation of the immune system with tumor-specific vaccination. This has just become possible now that entire tumor DNA sequences get to be routinely read within two weeks, as part of clinical care.The solution that Frame Cancer Therapeutics has developed is a ground-breaking strategy for anti-cancer vaccination using off-the-shelf yet personalized cancer vaccines derived from frameshift mutations. Frame Therapeutics has discovered FRAMES, a source of shared neoantigens induced by frame-shift mutations with unique therapeutic potential. These sequences are usually not expressed in the healthy body, and thus seen as foreign by the immune system. A licensed sets of FRAMES are each specific vaccines for different tumor types (such as breast, lung, kidney, colon, uterine cancer).Most cancer vaccination strategies are based on point mutations unique for each tumor, requiring costly individualized vaccine manufacturing. Frame Therapeutics is the first company entirely focusing on the development of cancer vaccines based on FRAMES, offering off-the-shelf personalized cancer vacc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable COnservation and REstoration of built cultural heritage', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

SCORE brings together interdisciplinary and inter-sectorial research and innovation teams involved in sustainable conservation of built cultural heritage from 4 European (France, Italy, Spain, Denmark) and 2 Latin America (Colombia, Mexico) countries. Consortium includes academics, governmental institutions, SME and NGO. The goal is to develop international partnerships and to exchange highly qualified expertise in order to propose solutions for green restoration and rehabilitation works. These conservation materials and methods must minimize their ecological footprint according to the EU circular economy action plan and be durable in a changing climate. In order to propose solutions for a large variety of built cultural heritage, two kinds of application cases have been selected, archaeological sites in Yucatan peninsula with an equatorial climate, and vernacular built cultural heritage in different types of warm temperate climates in Europe, using different building materials and techniques.The future development of buildings conservation must be founded on previous experience cumulated during thousands of years and must take advantage of recent progress in technology. Thanks to the emission scenarios and climate models, future environments may be considered to increase the durability of the materials and methods proposed. Main pillars underpinning the SCORE project are:•Circular economy principles •Heritage management including valorisation of built cultural heritage •Development of sustainable and durable conservation techniques for vernacular and monumental architecture•All masonry materials are concerned, traditional and non-traditional ones •Life Cycle Assessment techniques to estimate and minimize ecological footprint•Service life prediction to ensure the durabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Explainable Anomaly Detection for Safeguarding and Enhancing Modern Data Industry' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the ExplainableAD project, we address the problem of eXplainable Anomaly Detection (XAD) on data streams with evolving, previously unknown, complex anomaly types. To bridge the gap between growing demands in the data industry and severely limited industry-grade solutions available today, we propose a breakthrough XAD system that offers unprecedented capabilities for safeguarding digital services. To this end, it seamlessly integrates deep learning-based anomaly detection (AD), which unlocks the power of detecting evolving, previously unknown, complex anomaly types, and explanation discovery (ED), which overcomes the non-interpretability of deep learning by returning human-readable, actionable insights. To establish a pathway from fundamental research to innovation, we will conduct 1) additional research activities on automated model selection, scalable execution, and data visualization; (2) prototyping, benchmarking analysis, and system demonstration; (3) large-scale use case studies with industry partners, leveraging ongoing collaborations and building new use cases across banking, finance, and healthcare domains; (4) market analysis and market entry strategy development to enable technology transfer. Our XAD system will have a direct impact on end users across a variety of sectors, including fraud analysts in banking and financial services to combat ever-growing, complex fraud types, IT departments and cloud services to manage malfunction and performance challenges proactively, and biomedical researchers and staff to benefit from enhanced diagnostic accuracy and improved confidence. The PI will bring extensive experience from the ERC CoG grant, including a large number of publications and a highly skilled team, to this project. With a proven track record of deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Made in China to Created in China - A Comparative Study of Creative Practice and Production in Contemporary China' (ChinaCreative).

assistant: **Concept**

With its emergence as a global power, China aspires to move from a “made in China” towards a “created in China” country. Creativity and culture have become a crucial source for innovation and financial growth, but are also mobilised to promote a new and open China to both the citizenry as well as the outside world. They are part of what is termed China’s “soft power.”What does creativity mean in the context of China, and what does it do? When both the state and profoundly globalised creative industries are so deeply implicated in the promotion of creativity, what are the possibilities of criticality, if any? Whereas creativity has been extensively researched in the fields of psychology, law and neurosciences, scholarship in the humanities has by and large side-tracked the thorny issue of creativity. Yet, the worldwide resurgence of the term under the banner of creative industries makes it all the more urgent to develop a theory of creativity. This project understands creativity as a textual, a social as well as a heritage practice. It aims to analyse claims of creativity in different cultural practices, and to analyse how emerging creativities in China are part of tactics of governmentality and disable or enable possibilities of criticality.Using a comparative, multi-disciplinary, multi-method and multi-sited research design, five subprojects analyse (1) contemporary art, (2) calligraphy, (3) independent documentary cinema, (4) television from Hunan Satellite TV and (5) “fake” (shanzhai) art. By including both popular and high arts, by including both more Westernized as well as more specifically Chinese art forms, by including both the “real” as well as the “fake,” by studying different localities, and by mobilising methods from both the social sciences and the humaniti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computing Patterns for High Performance Multiscale Computing' under Horizon 2020.

assistant: **Concept**

Multiscale phenomena are ubiquitous and they are the key to understanding the complexity of our world. Despite the significant progress achieved through computer simulations over the last decades, we are still limited in our capability to accurately and reliably simulate hierarchies of interacting multiscale physical processes that span a wide range of time and length scales, thus quickly reaching the limits of contemporary high performance computing at the tera- and petascale. Exascale supercomputers promise to lift this limitation, and in this project we will develop multiscale computing algorithms capable of producing high-fidelity scientific results and scalable to exascale computing systems. Our main objective is to develop generic and reusable High Performance Multiscale Computing algorithms that will address the exascale challenges posed by heterogeneous architectures and will enable us to run multiscale applications with extreme data requirements while achieving scalability, robustness, resiliency, and energy efficiency. Our approach is based on generic multiscale computing patterns that allow us to implement customized algorithms to optimise load balancing, data handling, fault tolerance and energy consumption under generic exascale application scenarios. We will realise an experimental execution environment on our pan-European facility, which will be used to measure performance characteristics and develop models that can provide reliable performance predictions for emerging and future exascale architectures. The viability of our approach will be demonstrated by implementing nine grand challenge applications which are exascale-ready and pave the road to unprecedented scientific discoveries. Our ambition is to establish new standards for multiscale computing at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Predictive modelling of GPCR druggable allosteric sites' (MIDAS), addressing dissemination and exploitation.

assistant: **Impact**

G protein coupled-receptors (GPCRs) are the most successful class of druggable targets in the human genome with an estimated 30 to 60 % of prescription drugs in European Union. GPCRs biological state can be modulated by small molecule ligands acting on spatially distinct allosteric binding sites (ABSs) that result more selective and less toxic than drugs binding to orthosteric sites. The discovery of lead compounds targeting ABSs is challenging and to date has largely been achieved through cost-intensive and time-consuming high-throughput screening. The recent release of X-ray structures of GPCRs in the complex with allosteric modulators opens new opportunities to develop structure-based computer aided methodologies to identify ABSs.MIDAS will aim to develop a computational methodology for the search of GPCR ABSs that will include cutting-edge enhanced sampling molecular dynamics simulation methods in cosolvent mapping. The action will solve several current limitations in cosolvent mapping: probe non-specific binding, protein denaturation, low probe sampling, and membrane distortion. MIDAS firstly develop the methodology in retrospective studies, aiming to identify ABSs in the M2, CRF1, P2Y and GCGR receptors for whom crystal structures complexed with allosteric modulators are available. The computational procedures will be developed for identification of extracellular and intracellular ABSs and ABSs at the interface between GPCR helices and lipids. Next, MIDAS will explore the developed protocols in prospective studies using the M3, µ-opipid and CCR5 receptors with available X-ray structures and known ligands. The action envisions the collaboration with experts from both academia and industry and is set to expand scientific, transferable and collaborative skills of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Inter-bacterial competition mediated by the type VI secretion system (T6SS): promising role in the biocontrol properties of Pseudomonas putida' (T6SS).

assistant: **Concept**

Bacterial type VI secretion systems (T6SSs) are recently discovered nanomachines used to inject effectors into prokaryotic or eukaryotic cells. Therefore, T6SSs are involved in both inter-bacterial competition and bacterial pathogenesis. In this project, I propose to study the T6SS of Pseudomonas putida a soil bacterium with the capacity to colonise the root of crop plants. The colonisation by this bacterium provides growth advantages to the plant and, importantly, protection against plant-pathogens. This makes P. putida a relevant biocontrol agent. Since T6SS is mainly used by environmental bacteria for inter-bacterial competition, one might speculate that T6SSs play a relevant role in the biocontrol properties of P. putida. An in silico analysis of P. putida KT2440 genome revealed the existence of three putative T6SSs: H1, H2 and H3. I have determined that H1-T6SS is active and can be used to kill the serious phytopathogen Pseudomonas syringae. Mutants in H1-T6SS structural components lack the ability to kill model prey strains. In this project, I propose to use these mutants in competition assays with several microorganisms to further identify H1-T6SS targets, especially other resilient phytopathogens such as Agrobacterium tumefaciens and Ralstonia solanacearum. Furthermore, I will assess the role of T6SSs in the biocontrol properties of P. putida using infected plants. Moreover, I have identified novel H1-T6SSs effectors and their cognate immunity proteins (EI pairs) which belong to EI families without functionally characterised members. I will characterise the identified EI pairs at a functional, biochemical and structural biology level.In addition to the fundamental interest of the characterisation of new T6SSs, elucidation of their role in the biocontrol activity