RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High level integrated design environment for dependability' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The main objective of HIDE is the creation of an integrated environment for the practitioner designer, allowing him to use UML (Unified Modelling Language) as front-end for the specification of both the system and the user requirements. The designer can easily validate his design, since the entire background mathematics will be hidden from him. From the basic UML model automatic transformations will derive the individual mathematical models for formal and quantitative validation. The results gained will be back annotated for presentation into the same UML model without any interaction of the user. HIDE eliminates the need for both a specific expertise in abstract mathematics and the tedious manual re-modelling of the system for mathematical analysis. The major objective of Phase 1 is an experimental platform for the validation of the conceptual aspects of HIDE, while Phase 2 serves for the pre-prototyping of a commercial version.ResultsHIDE is the first attempt to directly bridge the gap between a practice-oriented CASE methodology and sophisticated mathematical tools. At the end of the project a complete prototype of HIDE and an assessment of the market potential will be provided.The practical innovation is the incorporation of the crucial aspects of formal validation, performability and dependability analysis, and synthesis support without the need of special skills or extreme efforts by the designer. The major scientific value of this project is the know-how in using existing mathematics and solution methodologies in problem formulation and solution, and in the general methodology of model transformation and integration into the practical design process. The openness of the approach allows the further integration of other validation and analysis tools.ApproachTo obta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'DIAmond Devices Enabled Metrology and Sensing'.

assistant: **Innovation**

The DIADEMS project aims at exploiting the unique physical properties of NV color centres in ultrapure single-crystal CVD-grown diamond to develop innovative devices with unprecedented performances for ICT applications. By exploiting the atom-like structure of the NV that exhibits spin dependent optical transitions, DIADEMS will make optics-based magnetometry possible.The objectives of DIADEMS are to develop- Wide field magnetic imagers with 1 nT sensivities,- Scanning probe magnetometer with sensitivity 10 nT and spatial resolution 10 nm,- Sensor heads with resolution 1 pT.<br/>To reach such performances, DIADEMS will:- Use  new theoretical protocols for sensing,- Develop ultrahigh purity diamond material with controlled single nitrogen implantation with a precision better than 5 nm,- Process scanning probe tips with diametre in the 20 nm range,- Transfer them to AFM cantilever, improve the emission properties of NV by coupling them with photonic  cavities  and photonic waveguides.<br/>DIADEMS outputs will demonstrate new ICT functionalities that will boost applications with high impact on society:- Calibration  and optimization of write/read magnetic heads for future high capacity (3 Tbit per square inch) storage disk required for intense computing,- Imaging of electron-spin in graphene and carbon nanotubes for next generation of electronic components based on spintronics,- Non-invasive investigation of living neuronal networks to understand brain function,- Demonstration of magnetic resonance imaging of single spins allowing single protein imaging for medical  research.<br/>DIADEMS aims at integrating the efforts of the European Community on NV centres to push further the limits of this promising technology and to keep  Europe's prominent position.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dendro-somatic Coupling and global neuronal signaling' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The mechanism for anaesthesia has eluded neuroscience despite being used as a medical intervention for more than two centuries. Two facts are clear: loss-of-consciousness under anaesthesia correlates with a massive reduction in global neuronal signalling and a de-coupling of feedback information. We recently found that the apical dendrites of layer 5 pyramidal neurons are effectively ""cut off"" from the cell body under anaesthesia and that higher order thalamic input maintains dendro-somatic coupling via the activation of metabotropic glutamate and acetylcholine receptors. We hypothesize that dendro-somatic coupling, the influence of the apical dendrite on the soma, regulates the flow of information around the brain. If true, this would mean that dendro-thalamic coupling is a ubiquitous mechanism by which the brain, via thalamo-cortical interactions, can regulate the degree to which feedback is reintegrated into any given cortical column. Moreover, since human pyramidal neurons are twice as long as rodent neurons, the issue of dendro-somatic coupling in human neurons is even more profound. Here, we propose to comprehensively investigate this cortical coupling mechanism in vitro and in vivo using state-of-the-art approaches developed in my laboratory and specifically designed to investigate dendritic signalling. We will also perform experiments in resected cortical tissue from human patients using fast-viral expression of optogenetic constructs, an approach that we have also developed and tested in my laboratory. Lastly, we use modelling to probe the consequences of dendro-somatic coupling both for single-cell computation and the principles of multi-compartment neuronal networks. Dendro-somatic coupling as a dynamic mechanism for global neuronal signalling is a bold new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improving Metabolism via Prolonged Bile Acid Signallingtargeting hepatic bile acid uptake to fight metabolic diseases' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Bile acids play a pivotal role in energy supply as they facilitate the solubilization and absorption of fat in the intestine. Furthermore, bile acids are recently identified as important signalling molecules regulating glucose metabolism, inflammation and energy expenditure. Targeting bile acid signalling is, therefore, appealing to treat metabolic diseases such as diabetes and atherosclerosis. These disorders are potentially affecting >1 billion individuals worldwide and current options to treat them remain insufficient. I postulate that the hepatic bile acid uptake transporter NTCP (gene name SLC10A1) provides an excellent novel target to improve human health as it determines the duration of bile acid signalling by controlling how fast bile acids are removed from serum after a meal. In this proposal I will elucidate the contribution of bile acid dynamics to energy homeostasis and metabolism and identify the molecular mechanisms that regulate NTCP.  My aim is to generate novel strategies to reduce hepatic bile acid uptake to prolong bile-acid signalling and increase energy expenditure, improve glucose handling and reduce atherosclerosis.My key objectives are:1.to determine the consequence of NTCP modulation on systemic bile acid dynamics, glucose and energy metabolism in animal models. To this end, I will perform careful metabolic analysis of a unique Slc10a1 knockout model in combination with diet-induced and genetic models for atherosclerosis and diabetes.2.to identify novel means to inhibit NTCP-mediated bile acid uptake. To this end, I will make use of a FRET-based bile acid sensor that I recently developed to characterize the molecular regulation of hepatic bile acid uptake and to identify FDA-approved drugs that inhibit NTCP-mediated bile acid uptake.This will es
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Governance and business models for living labs: rural regeneration hubs for tackling soil health challenges in the Mediterranean region' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In the EU, 60-70% of soils are degraded as a direct result of unsustainable management. However, tackling this multifaceted challenge is not an easy task, mainly because farmers' decisions are influenced by a wide range of factors, making it difficult to define regenerative soil management practices that are simultaneously effective, economical, have demonstrable yield benefits and are easy to implement. In this context, the goal is to foster a collective awareness, at the the level of five Mediterranean regions, that soils and humans must be understood as social-ecological systems and that no organisation/solution alone is capable of sustainably transforming the system. The desired change can only emerge when the innovation process is supported by an exploration phase enabling actors to identify their personal (from individuals to organisations) drivers, ultimately aligning purposes and behaviours toward impactful collective actions. To demonstrate this, the project will apply co-creation tools to multi-actor governance structures, emphasising the building up of a shared awareness of soil threats over the identification of specific technologies. The main objectives of the proposed plan are: 1) to explore regional needs and drivers, and to validate governance models for operating multi-actor co-creation processes; 2) to establish a network of five agro-innovation hubs sustained by underlying business models; 3) to define harmonised regional baselines for 7 out of the 8 indicators found in the Soil Mission Implementation plan; 4) to kick-start the multi-actor co-design and validation of solutions for soil health that are practical and scalable; 5) to facilitate the diffusion of innovation through a plethora of communication and dissemination actions. GOV4ALL concentrates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Take Control' in the context of a Horizon 2020 call.

assistant: **Objectives**

TACO aims to define an automated system sufficiently powerful to both accomplish complex tasks involved in the management of surface movements in a major airport and self-assess its own ability to deal with non-nominal conditions. When needed, such system should be sensitive enough to transfer responsibilities for traffic management back to the controller, in a timely and graceful manner and in way that makes him/her comfortable with the inherited tasks.Automation is one of the key solution proposed and adopted by SESAR to tackle the challenges coming from the increase of capacity and complexity of the future ATM system. On the one hand, the programme aims at substantially reducing controller task load per flight through a significant enhancement of integrated automation support, whilst simultaneously meeting the established safety and environmental goals. On the other hand, it is envisaged that human operators will remain at the core of the system (mainly with the role of overall system managers) using automated systems with the required degree of integrity and redundancy. TACO proposes a dove tailed process to facilitate the controller’s forward thinking, also in anticipation to A-CDM (Airport- Collaborative Decision Making) amongst others.Following the two grounding principles of automation in SESAR, TACO project aims at:defining algorithms and solutions to automate and optimize both the decision making and implementation tasks for the controller involved in the ground movement of airport vehicles and aircraft;identifying and providing the controller with suitable and usable tools to supervise (monitor, tune and re-program) the system;studying the interaction between the human actors and the automation. Main focus will be on the identification of sensitive state tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reincarnation of construction products and materials by slowing down and extending cycles' (Reincarnate) targeting Horizon Europe.

assistant: **Abstract**

Reincarnate aims at enabling the European construction industry to significantly reduce construction and demolition waste (CDW) by providing a circular potential assessment information model platform (CP-IM) and a set of innovations to make use of the CP-IM. The CP-IM will provide a digital representation of building materials and products with life-cycle information and prediction methods for tracing and predicting the lifetime of a products / material. The CP-IM will also allow for assessing the potential for lifetime extension and reuse and possibilities to predict circular value flows.  Based on the CP-IM REINCARNATE will develop and demonstrate ten innovations that use CP-IM data, ranging from innovations for building inspection, to solutions for planning construction and dismantling, to automatically identifying and sorting CDW, to decision support tools for architects and real estate managers. The innovations will draw upon emerging digital technologies, such as digital twin representation, artificial intelligence, and robotic automation. REINCARNATE will also develop detailed social science insights about the social adoption behavior existing in the wider construction industry that will allow for understanding how a wide realization within the industry can be established that building products and materials can be reincarnated and re-used in high product quality. All innovations will be demonstrated on five selected demonstrators. Business process guidelines, an online learning platform with training materials and proposals for standards will be developed to additional foster widespread dissemination and exploitation of the REINCARNATE results. The REINCARNATE consortium combines 16 partners from different EU member countries and Hong Kong with strong expertise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowing the enemy: unravelling a novel regulatory system involved in bacterial virulence' in the context of a Seventh Framework call.

assistant: **Objectives**

The emergence and increasing prevalence of bacterial strains resistant to antibiotics demand the discovery of new therapeutic approaches. Inhibition of pathogenesis by targeting bacterial virulence represents a promising alternative for antimicrobial therapy. A central requirement of bacterial virulence is the ability to tightly regulate virulence genes in response to host signals. Besides the two-component regulatory system, cell-surface signaling (CSS) represents an important mechanism by which bacteria respond to the medium. However, whereas regulation by two-component systems has been studied in great detail, little emphasis has been on CSS regulation, although it offers great potential for the development of antimicrobial compounds. In this project I propose to characterize a novel CSS regulatory system (PUMA3) which I recently discovered and that triggers the production of Pseudomonas aeruginosa virulence factors in response to a (human) host signal. P. aeruginosa is a major human opportunistic pathogen causing infections in hospitalized patients. It is also the main cause of death of patients suffering from cystic fibrosis. Due to its natural resistance to antibiotics and its ability to acquire such resistance, P. aeruginosa infections are often difficult to treat. The P. aeruginosa PUMA3 system consists of an extracytoplasmic function (ECF) sigma factor, a sigma factor regulator in the cytoplasmic membrane, and a receptor. Presence of an inducing signal results in the activation of the sigma factor, which binds to the RNA polymerase and promotes the transcription of a specific set of virulence genes. Induction of PUMA3 increases P. aeruginosa virulence. In this project I will characterize this novel regulatory system in detail, identify the inducing conditions a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'integrated urban FOOD policies – developing sustainability Co-benefits, spatial Linkages, social Inclusion and sectoral Connections to transform food systems in city-regions' to be submitted under Horizon Europe.

assistant: **Abstract**

Europe’s urban areas face significant challenges to ensure the availability and consumption of healthy, affordable, safe and sustainably produced food. Such challenges converge within local food environments, but are often neglected by public planners. Promising initiatives taken by municipalities to change the architecture of food choice often fail to become embedded in the wider policy context and to reach deprived and vulnerable groups. Key factors responsible for this are: (1) siloed ways of working and  (2) fragmentation of knowledge on facilitators and barriers related to food system transformation. These factors hinder the development and implementation of integrated urban food policies.FOODCLIC will create strong science-policy-practice interfaces across eight European city-regions (45 towns and cities). The backbone of such interfaces will be provided by Food Policy Networks, which will manage real-world experimental Living Labs to build a policy-relevant evidence-base through learning-in-action. Activities will be informed by an innovative conceptual framework (the CLIC), which emphasizes four desired outcomes of food system integration (sustainability co-benefits, spatial linkages, social inclusion and sectoral connectivities). Capacity-building and direct support for intensive multi-stakeholder engagement (including deprived and vulnerable groups) will enable policy actors and urban planners across partner city-regions to develop continuously evolving integrated urban food policies and render planning frameworks food-sensitive. Results will be communicated and disseminated amongst others by extending the novel policy practices to another eight city-regions in Europe and Africa, an online Knowledge-Hub, a high-level Think Tank and partners’ networks.In these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Next Generation Science Challenges Using Digital and Social Media to Make Science Education and Careers Attractive for Young People' to be submitted under Horizon 2020.

assistant: **Abstract**

Science education is tremendous in shaping the present and future of modern societies. Thus, the EU needs all its talents to increase creativity and competitiveness. Especially young boys and girls have to be engaged to pursue careers in Science, Technology, Engineering and Mathematics (STEM). However, statistics still show that enrolment rates in STEM-based degree programs are low and will lead to a workforce problem in industries, especially in many of the new member countries. The SciChallenge project focuses on developing novel concepts to actively integrate young boys and girls in science education using a contest-based approach to self-produced digital education materials from young people for young people. Driven by inspirational topic sheets, guides and toolkits created through this project and distributed by partner schools, teachers, and other youth-oriented institutions, contestants (individuals or groups) between the ages of 10 to 20 will generate creative digital materials (videos, slides, or infographics). The initiative will broadcast and distribute content over various social media channels and aggregated on a modern SciChallenge Web Platform (www.scichallenge.eu) to generate wide reaching awareness and promotion. Winning submissions will receive prizes funded by science-oriented industry and stakeholders.Intelligent cross-sectoral positioning of various awareness modules on the SciChallenge Open Information Hub will increase awareness on science careers and open opportunities for youngsters on internships or taster days in STEM through the strong involvement of related organisations and industries. Additionally aggregated information on science events (slams, nights, festivals etc.) is shared.With this multi-level approach, SciChallenge will boost the a