RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'New Applications and Performance Extension of Mass Produced Heavy Duty Powder Metallurgy Transmission Components by Warm Compaction' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The density is the most important feature in powder metallurgy. The higher the density, the better the properties, especially those of fatigue and impact because of their exponential dependency on density. There are three techniques in mass production to produce different density levels (in the order of increasing production costs): Single pressing and sintering technique (up to 7.2 g/cc ), double pressing and sintering (between 7.2 and 7.5 g/cc) and powder forging (between 7.5 and 7.85 g/cc). The most important need and issue in the powder metallurgical industry and consequently the required innovation is the production of high densities at acceptable costs: it would be a break through if the density level feasible by the double préssing and sintering technique can be produced at competitive costs by the warm powder compaction technology (7.2 to 7.5 g/cc) in the single pressing and sintering route. This would open a variety of new heavy duty applications in automotive and mechanical engineering and increase the volume of such parts which presently amounts to 25 % of the PM'business by at least 50 %. The warmcompaction technology promises an economic way to realise parts with high densities around 7.4 g/cc, tensile strengths Rm = 900 to 1000 MPa and fatigue endurance limits oe = 350 to 450 MPa (depending on the post sintering heat treatment) which otherwise could be manufactured by the double pressing and sintering technique or powder forging if the latter two ways were not expensive. As the warm powder compaction is not yet established generally in production scale with the necessary reliability and economics for mass production, e.g. of fatigue and impact loaded automotive parts, particular efforts are necessary in order to install this technology and to gain a lead o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Spying on Ultrafast Structural Changes Through Three Sets of Eyes'.

assistant: **Innovation**

Modern ultrafast laser technologies have initiated a 'femtosecond revolution' revolution in chemical physics, allowing the motion of nuclei within molecules to be visualised on the femtosecond (millionth of a billionth of a second) timescale. The insights from femtochemistry experiments allow detailed probing of the mechanics underpinning chemical reactions, and are therefore invaluable for fundamental investigations into molecular structure and reactivity. This proposal aims to advance understanding of how carbonyls, a key class of organic molecules found within the earth’s atmosphere (with important implications for understanding radiative forcing and climate change), react upon excitation by ultraviolet light, using state-of-the-art ultrafast experimental techniques. Whilst this crucial photochemistry has been studied by other techniques previously, a deep understanding of the complex electronic and nuclear dynamics which control the outcomes of the possible photoreactions is, so far, elusive. Throughout the grant, three different experimental techniques (ultrafast electron diffraction, ultrafast X-ray diffraction and Coulomb explosion imaging), each offering complementary structural information, will be exploited to gain an exquisitely detailed view of this important fundamental photochemistry. By studying a series of related carbonyl molecules, insights will be gained into the broad class of carbonyl molecules as a whole. Furthermore, the results will also assess the relative applicability of these experimental techniques (which have only been facilitated by recent technological advancements in the field of free-electron laser science) to probing complex molecular photochemistry on the shortest timescales. Consequently, the results will be of wide-reaching impact b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Knowledge for Ignition, Acoustics and Instabilities' in the context of a Seventh Framework call.

assistant: **Objectives**

For the time being, the European engine industry does not have at its disposal methodologies adapted to predict the unsteady behaviour of low NOx combustors. Consequently and in order to be able to set up the development of low NOx technologies, KIAI will deliver reliable unstationary CFD tools which will allow a deep comprehension of unsteady phenomena. The main objective of the KIAI project is to provide reliable methodologies to predict the stability of industrial low NOx combustors, as well as their ignition process from spark to annular combustion. When used at an early stage in the conception cycle of low NOx combustors, KIAI CFD methodologies will play a key role and considerably accelerate the delivery process of lean combustion technology with a proven capability to reach the 80% NOx emissions reduction required for introduction into service before 2020 with the necessary reliability, safety and economical viability. As already demonstrated by past and ongoing studies and European projects, low NOx technologies lead to crucial unsteady phenomena that are neither controlled nor predictable at the moment. The scientific objectives of KIAI are directly linked to a better understanding and prediction of these unsteady phenomena: 1) Predict the coupling between the acoustics and the flame. 2) Determine the acoustic boundary conditions of multiperforated plates surrounding the combustion chamber; 3) Account for non-premixed spray flows in the combustion process; 4) Explore aerodynamic unsteadiness in strutted pre-diffusers adapted to high mass flow injectors and develop a liquid film break-up model for an injector; 5) Evaluate the sensitivity of LES predictions to small technological variations of geometry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Progressive myoclonic epilepsy and neuronal apotosis. a genetic, molecular biological, biochemical and pharmacological approach to cystatin b and cysteine proteases.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Epilepsies represent a serious medical and social problem. Defects in a cysteineproteinase inhibitor, cystitis B (CSTB) gene were found by one Contractor to be responsible for progressive cyclones epilepsy of Unverricht-Lundborg type (EPM1)-an autosomal recessive neurodegenerative disease. We will use in vitro and in vivo approaches to understand the mechanisms by which deficiency of CSTB leads to the human disease. The current hypothesis is that deficiency of CSTB promotes neuronal apoptosis. We will develop a diagnostic test based on CSTB protein detection that is faster, cheaper and more reliable than the current DNA-based test. Unravelling the role and mechanisms of CSTB in cell death will allow the development of new and improved treatments that would result in considerable progress in the management of EPM1 patients by improving the quality of life of the individuals concerned by delaying or preventing the onset of disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Time-resolved structural studies of photochemical reactions by anomalous x-ray scattering'.

assistant: **Objectives**

Research objectives and content Our objective is the study of the phototdissociation dynamics in molecular systems in liquids via time resolved x-ray scattering. In contrast to conventional methods ( transient absorption, time-resolved Stokes-shift, etc.). This technique allows the direct observation of nuclear motion (bond-length) with PS time resolution. Emphasis is put on the theoretically predicted effect of the solvent configuration on bond making and breaking mechanisms in the systems mercury iodide, iodide as ion and iodide as neutral molecule in methanol. Furthermore the planned application of a jitter free streak camera extents the available resolution in the sub-ps time-domain which makes real-time observations possible. Training content (objective, benefit and expected impact) During the work for my diploma thesis I got used to spectroscopic techniques like transient absorption and single photon counting which were in the sub-ps and ps-range. In the group at the UJF which has a good infrastructure for research and well established cooperations with other groups I would have the opportunity to become familiar Bith other techniques and with my acquired knowledge only a short training period would be necessary. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Microtubule dynamics and neuronal cargo trafficking during dendrite to axon switching' to be submitted under Seventh Framework.

assistant: **Abstract**

Neurons are highly polarized cells, possessing two distinct types of processes, dendrites and a single axon. In cultured mammalian neurons, axons have uniform polarity microtubules (MTs) with plus ends distal to the cell body, while dendrites have mixed polarity with about half plus-end-out and half minus-end-out MTs. Several studies suggest that neurons have a tremendous capacity for axon regeneration, even in response to total axon removal they can convert a dendrite to a regenerating axon. This process of regenerating does seem to be accompanied by changing the MT cytoskeleton from the dendritic polarity to the axonal one. Various signaling molecules are implicated in the early events of neuronal polarization, but little is known about regulation of MT polarity orientation during these initial stages and in processes involves in rebuilding the entire neuronal MT cytoskeleton.The purpose of this project is trying to understand the mechanism underlying the rearranged of MT dynamics and polarity after axon removal in hippocampal neurons. First, we will describe this re-polarization and MT dynamics during axonal regeneration, and then we will deepen in how microtubule-associated proteins +TIPs, motor proteins, like dynein, and Rho-GTPase proteins could regulate this process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Scaffold hybridization approach targeting PPIs'.

assistant: **Objectives**

Protein-protein interactions (PPIs) control all cellular processes relevant to health and disease, hence an outstanding challenge in chemical biology is to develop generic approaches for PPI inhibition. Such inhibitors (or chemical probes) represent unique tools to understand biological processes and starting points for drug discovery, for treatment of multiple illnesses for which effective treatments don’t currently exist e.g. cancer. SHAPPI will allow Zsofia Hegedus (the fellow) to join the laboratory of Andrew Wilson (host supervisor) at the University of Leeds (Host) and develop research expertise in the area of inhibiting protein-protein interactions. In doing so, she will (a) enhance her prospects to become an independent academic group leader and (b) address the need to train researchers in this key area of chemical biology and (c) develop cutting edge methods that advance peptidomimetic approaches for inhibition of protein-protein interactions. Scaffold hybridization will allow the combination of molecular scaffolds capable of hot spot mimicry with molecules that influence selectivity or potency. In combination with reversible chemistry this will allow generation of dynamic combinatorial libraries of rapid identification of selective and potent inhibitors. The fellowship will explore proteomimetic-peptide conjugates and peptide-small molecule dynamic combinatorial libraries to accelerate development of selective PPI inhibitors using two model interactions; HIF-1α/p300 and BID/BAX, both of which represent important targets for anticancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DISCOVERY, IDENTIFICATION, APPLICATION, AND MONITORING OF DEVELOPED SOLUTIONS FOR INNOVATION FUND' to be submitted under Horizon Europe.

assistant: **Abstract**

To achieve the aim of the topic, a systematic approach will be developed and applied to select H2020 results and owners, to support the project development and finally to derive Innovation Fund-ready projects.The ETS Innovation Fund (IF) fosters low-carbon processes and technologies – and many results from H2020 provide promising solutions to be deployed. However, translating R&D results into products and processes and developing viable business cases is a major effort. Beyond that, it is a further great step to mobilise investors and stakeholders to make the projects fly. The IF regulations are challenging for the industry. To cope with all challenges related to the project development and preparation phase of future IF projects, DIAMONDS4IF is designed to:a) securing the viability and readiness of the projects,b) enabling applicants to prepare IF applications,c) developing a comprehensive approach towards stakeholders, investors, the public, and across the value chain,d) creating understanding of and preparing compliance with relevant regulations, guidelines, and framework conditions ande) solving questions and challenges arising from the project planning in line with funding requirements and award criteria.Through exemplary work on specific use cases in the field of renewable energy, a toolbox with the necessary methods and tools will be developed and applied. One of the major outputs of the project will be at least 5 sound proposals including the detailed plans for scalability, commercialisation, and financial models to be presented to the IF.Over the medium term, DIAMONDS4IF will develop and nurture a continuous innovation pipeline from H2020 innovations to deployment, which will exploit the synergies between the programmes. The use cases will e.g. directly impleme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Wind energy assessment and wind engineering' (WINDENG), addressing dissemination and exploitation.

assistant: **Impact**

Wind energy is in a period of very rapid development and becoming very competitive respect other energy sources. In this fast growing business, the development toward bigger, and more efficient wind turbines has put still greater emphasis on understanding the temporal and spatial variation of the mechanical loads created by the wind. Especially in very complex mountainous terrain the simple models for wind and turbulence become deficient. Also in offshore wind farms, a whole new set of questions arises. Economical aspect of the field must also be taken into consideration regarding siting of turbines within a wind farm. In order to cope with this broad range of problems it is necessary to prepare young scientists with a comprehensive view of different research methods especially in this important field for environmental and economical future of Europe such as wind energy development. In this applied field is necessary that training is conducted in close co-operation with public or with private research institutions and supervision from University. Different approaches to research are necessary to form the skilled human resources needed for developing the requisite of European research and technology in the coming years.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New solution for fully automated analysis and reporting of routine musculoskeletal X-rays'.

assistant: **Innovation**

Routine radiology services are facing a huge problem on having efficient workflows to deliver X-ray analysis and diagnosisshortly after image acquisition – with patients waiting days or weeks for the results. The volume of X-rays scans is quicklygrowing year after year –more than 140 million X-rays analysis of the musculoskeletal (MSK) system were performed in2018 in Europe alone. The current number of radiologists is insufficient to efficiently analyse and deliver the medical reportshortly, causing unnecessary stress for patients and potential delay in the treatment. Thus, there is an urgent need forsolutions optimizing the workflow on routine radiology services.Radiobotics (RDB) has developed a comprehensive machine learning-based software tool that automatically analyses X-raysof the MSK system and generates the respective medical report. The algorithms used have been trained with datascreened and validated by our clinical partners, in order to mimic expert accuracy and a state-of-the-art performance. RDBautomatic software will greatly benefit: 1) radiologists/physicians (end-users) by lowering the time required to analyseimages and generate diagnostic reports; 2) hospitals (customers) by optimizing the services workflow, saving costs andoffering higher quality services; and 3) patients by having access to a faster and accurate diagnosis and consequently earlytreatments.AutoRay project will enable RDB to mature its product to a market-ready software suite addressing multiple conditions in multiple anatomical regions while ensuring a seamless integration in IT systems. In addition, it will provide a stage to a large-scale demonstration of its performance in clinical practice. Upon completion, RDB will open up for a very large business opportunity, providing a perspect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metabolic microenvironments in humoral immunity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Immune responses occur in often highly compartmentalised tissue microenvironments, which in turndefine local metabolic conditions. In the architecture of lymphoid tissue, very little is known aboutcellular metabolic interactions, or how immune cells adapt their metabolism in response to a changingenvironment. The humoral immune response is essential for normal immunity, and its centrepiece isthe germinal centre (GC) reaction, which allows the generation of high-affinity antibodies and B cellmemory. The GC is tightly spatially organised in lymphoid tissue, but how this microenvironmentshapes the metabolism of GC B cells is unknown. In this project, we will explore two fundamentalquestions in B cell metabolism. GC B cells, despite dividing at the highest rate of any cell, have ahighly distinct metabolism dependent on OxPhos. Yet, the processes which maintain this are poorlyunderstood. We will examine the role of dynamic mitochondrial morphology in GC homeostasis, usingcomprehensive metabolic and immune phenotyping across multiple genetic models. In the secondaim, we will explore the effect and sensing of environmental metabolites on GC function, and howstromal cells actively regulate their metabolic microenvironment, in both health and the autoimmunedisease systemic lupus erythematosus.