RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Codes for Design of Sustainable Structures'.

assistant: **Concept**

Given the tremendous challenges our society is facing, i.e. in regard to the expected changes in our environment due to climate change and the increasing pressure on our natural resources, the international research community is in demand to find solutions that provide the foundation for our sustainable development. Here, the built environment is of obvious importance as it not only facilitates societal activity but also has a major share on the worldwide turnover of economic and environmental resources.  To date the built environment is developed and maintained by broadly following structural design standards, which did evolve continuously over time and contain safety concepts that support daily structural engineering decision making based on simple calculus. The major objective that has been followed in their development, was the provision of sufficient safety, and the observed relative low failure rates do proof success in this regard. However, as conceived, structural design codes do not allow for the optimal allocation of the limited financial and environmental resources into the structural performance. In this context, the proposed project will develop methodologies to calibrate the safety concept of existing design standards, such that their broad implementation will lead to a significant increase of resource efficiency with simultaneous conservation of the present average safety level. Environmental, economic and societal aspects will be explicitly considered and the potential benefits will be exemplified on the building stocks of two European countries. Presented and disseminated by means of user-friendly tools and demonstrators in a form that is not only accessible to expert groups, but also to other stakeholders involved in standardization procedures, the res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Railway Vehicle Dynamics and Track InteractionsTotal Regulatory Acceptance for the Interoperable Network' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The certification of a rail vehicle according to European regulations, Technical Specifications for Interoperability, European Standards and national safety rules represents a significant element of both vehicle cost and time to market. Indeed, a large part of vehicle certification mandates testing for safety, performance and infrastructure compatibility. The new EN standards together with the CR/HS RST and INS TSI define test conditions and limit values for tests for acceptance of running safety parameters. DYNOTRAIN will contribute to the practical implementation of interoperability of railways systems across Europe by checking for inconsistencies and “open points” in the existing acceptance criteria and by proposing revisions of acceptance criteria in European standards and resolutions to close relevant “open points” in the TSI. The project aims at decreasing the costs associated with certification without reducing the safety level to enhance the competitiveness of rail traffic.The project is part of the TRIO-TRAIN cluster (Total Regulatory Acceptance for the Interoperable Network) which comprises 3 related projects dealing with key railway interoperability issues: Aerodynamics (AEROTRAIN), Railway Dynamics and Track Interaction (DYNOTRAIN) and Pantograph/Catenary Interaction (PANTOTRAIN) all submitted under the 2nd Call of the FP7. The objective of these projects is to propose an innovative methodology via a computer simulation/virtual homologation that will allow multi-system network and route approval in Europe to become a faster, cheaper and better process for all involved stakeholders. Therefore the success of the TRIOTRAIN cluster will lead to a time reduction for relevant parts of the certification process from 24 to 6 months; an 80% saving in effort for the a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of advanced tools for the production of artworks using marble powder (INDUSTRIAL WASTES)' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

EcoMarble aims to the intelligent production of solid marble artworks by using marble powder as primary material. The project introduces the intelligent computer based 3D-copy and design of art and cultural objects, and furthermore the manufacturing in industrial scale of true marble objects by processing marble wastes in powder form (inexpensive raw material). Results of the project will be applicable in the area of manufacturing of cultural objects, artworks or museum reproductions, conservation of cultural environment, etc. However it is expected that developed tools will launch spin-off applications in industrial sectors such as the automotive and electronic components industry, and bring new opportunities to the market and future initiatives as well.The subject of research is to develop all necessary tools to create a complete process chain consisting of:- 3-dimensional copy of historical objects;- optimised CAD environments to create artwork reproductions and modern design products based on historical ideas;- rapid prototyping directly in solid marble to cover one-step prototyping in the end material or limited series production;- rapid prototyping in very large sizes (world's largest stereolithography parts);- marble powder injection moulding to achieve high rates in production of solid marble objects;- electronic commerce application;- testing of complement.During the ecomarble project, the following major research results have been obtained:-Feasibility study on marble powder formulation, with the main objective to develop a binder system that allows the processing of marble powder in a freeform manner and in Powder Injection Moulding for higher rates.-Formulation of the suitable marble powder feedstock and test production.-Various testings of 3D copy methodolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Environmentally friendly multifunctional grease based on regrowing resources and advanced thickener technology to apply in loss lubrication earth moving equipment' (BIOGREASE) targeting Fifth Framework.

assistant: **Abstract**

Oils and greases used in total loss dry lubrication systems, as those applied unearth moving equipments, are some the products in which utilisation of biological resources, market requirements and economic, social and environmental benefits are best involved if a natural regrouping based grease is used. The developing attesting of these natural regrouping oil based greases to be used in earth moving equipments is the aim of the project. It leads to the increase of production and exploitation of biological materials for a non-food use in which market demand is opened due to the high level of public awareness of environmental issues and the big quantity of product used (25.000 Tm/year in Europe). Formulation of the new greases implies also the use of advanced thickener technology and laboratory, bench and field-testing of the new products. This project covers the Key action 5,Priority 5.2: The integrated production and exploitation of biological materials"
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Neuronal Dynamics of the Basal Ganglia and the Kinematics of Motor Habits' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Motor habits are well learned spatiotemporally ordered sequences of movements executed without being explicitly motivated by a goal. Habits are formed following long trial-and-error learning periods but once acquired they tend to persist even when their beneficial outcome is degraded. Despite the behavioral importance of habits and their dramatic alteration in several pathologies (Parkinson disease, Tourette syndrome, addictions) the neuronal mechanisms behind habitual actions are unclear. On the one hand, lesions or dysfunction of the basal ganglia (BG) are well known to alter the formation and execution of habits. On the other hand, it is generally assumed that the function of the BG is to initiate adapted actions while inhibiting unwanted ones. This action selection model implies that the BG does not contribute to the control of the kinematics of actions (how selected actions are executed). A major problem of the action selection model is that it does not explain why BG dysfunctions result in specific deficits in movement kinematics.Here, on the basis of recent findings from our team, we will test the hypothesis that, rather than selecting actions, neuronal activity in the BG plays a crucial role in controlling the kinematics of habitual actions. We will combine large-scale recordings of spiking activity in the BG (striatum) and related structures (primary motor cortex and thalamus) with optogenetic and pharmacological manipulations of neuronal activity in behaving rodents. Importantly we will use new behavioral tasks specifically designed to capture the often overlooked spatiotemporal structure of habits. The results obtained will shed new lights on the network and cellular mechanisms driving habits, the controversial function of the BG and the broader issue of moto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Hydro-erosion for repair of in-situ concrete' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Europe and the rest of the developed world face a growing crisis in the preservation of their built environment. Due to the so called 'concrete cancer', which is largely associated with acid rain and other agencies for decay, there is a multi BECUs accumulating annual need for repair in all manner of concrete structures in Europe, alone. This affects highways, bridges, buildings, factories, power-station, airports and coastal defences. The scale of this is indicated by the estimated 3 million kms of paved highway, 4.4 million dwellings in system buildings and 900,000 bridges in the European Community. Removal of defective concrete and replacement with protecting materials represents a significant part of the ongoing repair and maintenance of these. Hydro-erosion is a process by which defective concrete and other construction materials are removed by the action of a high pressure water jet. It is operated as a hand-held tool method, though a few mechanized systems have been produced. Whilst the latter promise significant advantages over hand-held tools, the lack of a suitable control method currently places significant limitations on these benefits. However, if a reliable control method can be established, then improvements in productivity, quality control and worker safety can be realised. Using the know-how to be worked out in the HEROIC project, a 8-12 increase in productively is anticipated through the inclusion of a control system which uses material property predictions and the sound and vibration of the hydro- erosion processes. The Research Feasibility Study, BRST-CT96 0385, which has addressed the extreme technical risk areas in the proposed innovation, indicates that it should be possible to achieve the control objective. Though for a substantially reduced powe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification and characterization of new drug resistance and host adaptation mechanisms in Mycobacterium leprae' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Leprosy is a multiform infection caused by Mycobacterium leprae, an uncultivable bacLeprosy is a slow and chronic infection caused by Mycobacterium leprae. Recent advances in the next generation sequencing offer a new possibility to study the physiopathology of M. leprae, an uncultivable bacteria on anexic media. In 2018, the comparative analysis of 154 M. leprae genomes from 25 countries identified three hypermutated genes including two (ribD and fadD9) probably associated with drug-resistant and the most mutated one being ml0411 with a potential role in host adaptation. In a mycobacterial species, like M. leprae, with such a reduced number of coding genes, it is reasonable to assume that this high rate of mutations probably led to the modification of essential biological functions. In addition, the recent development of more efficient molecular tools can now help to obtain the whole genome sequencing of the strain from the low representative forms of the disease. This could help to identify more of these highly mutated genes and establish a link between the pathogen genetic and the clinical disease outcome.   This project proposes to functionally characterize some of the mutations identified but also to identify new candidates which could be linked with differences in host phenotype.  The study has three specific aims: Specific aim 1 will focus on potential new genes involved in M. leprae drug resistance. Using surrogate mycobacteria such as M. tuberculosis and M. haemophilum, we will test the drug susceptibility of mutated strains in fadD9 and ribD compared to wild-type strains. In specific aim 2, we will investigate the role of ml0411 and mutated version on the host innate immune response modulation In specific aim 3, we will focus on the whole genome sequencing of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemistry and Physics of Multifunctional Materials' (1998-2002).

assistant: **Innovation**

Recent developments in the area of large molecular systems have convincingly demonstrated that synthetic chemistry is now in a position to jump the gap between ingeniously-designed model compounds and custom-designed practically useful materials. At the same time it is becoming progressively clear that novel practical or technological applications will only come within reach if these impressive synthetic strides are matched with a host of measurement techniques and characterisation experiments.In this context it seems natural to us to propose that an equal combination of selected synthetic chemists, physical and chemical experimentalists, and theoreticians, who - in different ways - have been devoting their research efforts to the study of large and complicated molecules, should form the constituency of the next meeting of the ESF Research Conference series Chemistry and Physics of Multifunctional Materials". The first highly successful meeting was held in Sept 97 under the title "Fullerenes in context", followed by "Taming Molecular Complexity" in Sept '99 and "Chemical Building Blocks for New Materials" in Sept '01. In "From Clever Molecules to Smart Materials" we propose to explore the idea that if materials scientists are to develop organic materials that match or exceed the performance of the known and prospective in organics, it will be necessary to make a systematic, coordinated effort across discipline boundaries.This requires scientists to assemble, characterize, measure, and model a whole range of variously derivatised systems according to a strategy that can only emerge if interactions between synthetic chemists, spectroscopists, theoreticians, materials scientists and industrial strategic researchers are enhanced. Targeted conferences such as the presently p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High temperature ultrasonic velocimetry (HITUV)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project will extend the applicability of the Ultrasound-Doppler Velocimetry to the range of high temperatures. Because the knowledge of the flow structure in opaque fluids has a large economical importance especially in branches like metallurgy or crystal growth technology, the interest is focused on flows of liquid metals. This project will allow the conception and development of an innovative measuring system that will determine real-time velocity profiles in high temperature liquid metals. Previous studies in special liquid metals at low temperatures (mercury, gallium) have proven the feasibility of this technique. One important issue of the project is the development of a transducer prototype for liquids of large economic relevance like liquid aluminium or steel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A study of the mechanistic basis for catalytic promiscuity in the alkaline phosphatase superfamily' (APCatProm) under Seventh Framework.

assistant: **Objectives**

Enzymes are the catalysts which allow important chemical reactions to occur on biologically relevant time-scales, and the current understanding of enzymes assumes that each enzyme is specifically tailored for a single reaction. Enzyme promiscuity refers to an enzyme’s ability to catalyze chemical transformations other than its native reactions. The identification of an increasing number of promiscuous enzymes challenges the classical “one enzyme, one activity” dogma.The notion that a single enzyme is capable of efficiently catalyzing a number of different reactions, which proceed through different transition states, is challenging to our current comprehension of enzymes. Although enzyme promiscuity is now a well documented phenomenon, the mechanistic principles underlying this behaviour are not well understood. This proposal aims to study catalytic promiscuity in the alkaline phosphatase superfamily, a class of phosphate and sulphate ester cleaving enzymes which are known to be prone to promiscuous behaviour. Specifically, linear free energy relationships will be used to characterize the bond-making and bond-breaking processes in phosphate/sulfate ester cleavage, and how the enzyme is able to stabilize these events. We will also use site directed mutagenesis and a high throughput selection system based on microdroplets to probe the contributions of individual amino acid residues to the catalytic mechanism and study enzyme evolution. Of particular interest is the question of how one enzyme active site is able to efficiently catalyze several thermodynamically demanding reactions which pass through transition states with vastly different properties under non-enzymatic conditions. In addition to enhancing our basic understanding of enzyme function and evolution, the mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'REVEALING MYOSIN'S POWER STROKE WITH HIGH-SPEED SCATTERING INTERFEROMETRY' (RMPSHSSI) targeting Seventh Framework.

assistant: **Abstract**

The fundamental goal of microscopic imaging is to visualize and identify small objects and observe their motion. Of the many available techniques, single particle tracking has been an immensely powerful tool in the life sciences for studying the motion of individual objects and thereby the function of a large variety biological processes. Despite considerable advances, following the motion of individual molecules on the relevant time and size scale has remained an insurmountable challenge. Here, we propose to construct a novel optical microscope based on interferometric scattering (iSCAT) detection that will bridge the considerable gap between the temporal and spatial accuracy provided by current single molecule methods.The primary objective of this work is to utilize the unique imaging properties of interferometric scattering detection to directly visualize and thereby understand the power stroke of Myosin V. Myosin V is a molecular motor, a cargo transporter that moves along actin filaments while hydrolyzing ATP. A wealth of knowledge concerning myosin’s function has been acquired over the past decades. Nevertheless, many of the fundamental questions concerning the mechanism of the power stroke for these motors remain, largely due to fundamental limitations associated with the employed techniques. In this respect, the application of high-speed iSCAT to study the motion of Myosin V will represent a significant step forward in our understanding of the functionality of this important motor.We aim that this work will establish iSCAT as a viable and powerful in vitro imaging platform with capabilities that are several orders of magnitude beyond what is currently possible with state of-the-art single particle tracking approaches. As a consequence, this proposal will include