RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Arylation and Vinylation of Enolates: New Reactivity from the Urea Linkage' (ENOLAR).

assistant: **Concept**

Enols and enolates are among the most versatile nucleophiles in chemistry: they react well with alkylating agents or carbonyl compounds, but their coupling with aryl or alkenyl halides is usually dependent on Pd-based catalysts for enol–aryl coupling. In this proposal we aim to develop new possibilities for enolate arylation that reveal fundamental new reactivity and will have repercussions throughout the science of synthetic planning. The method builds on some arylation reactions of urea-containing organolithiums, first reported in 2007, which turn out to be general for a variety of compound classes. Preliminary experiments show that enolates also undergo this arylation, providing a simple way of introducing an Ar+ equivalent to an enolate nucleophile without the need for heavy-metal catalysis.We propose to develop this reaction into a simple and versatile method for the challenging arylation of enolates. The resulting transformation will have broad application to the synthesis of biologically active targets, both natural and non-natural, of value to the pharmaceutical, agrochemical and related fine chemicals industries. Extension beyond the amino acids could see the method rooted among the canon of enolate-based C–C bond forming reactions.Key objectives are:• Arylation and vinylation of amino acids: We will optimise the enolate methodology for the synthesis of quaternary amino acid targets.• Controlling absolute configuration: We will develop an asymmetric version of the reaction (ideally based on chiral metal ligands, but alternatively other structures) for the enantioselective synthesis of quaternary amino acids.• Mechanistic investigation: Unravelling the remarkable mechanism of the reaction will throw light on other possible future directions for the research.• Ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '5G Programmable Infrastructure Converging disaggregated neTwork and compUte REsources' in the context of a Horizon 2020 call.

assistant: **Objectives**

The explosive growth of mobile internet traffic introduces the need to transform traditional closed, static and inelastic network infrastructures into open, scalable and elastic ecosystems supporting new types of connectivity, high mobility and new mission-critical services for operators, vendors and vertical industries.5G-PICTURE will develop and demonstrate a converged fronthaul and backhaul infrastructure integrating advanced wireless and novel optical network solutions. Τo address the limitations of the current D-RAN and C-RAN approaches, 5G-PICTURE will exploit flexible functional splits that can be dynamically selected, to optimise resource and energy efficiency.This results in a paradigm shift, from RAN and C-RAN to ʽDis-Aggregated RANʼ (DA-RAN). DA-RAN is a novel concept where HW and SW components are disaggregated across the wireless, optical and compute/storage domains. ʽResource disaggregationʼ allows decoupling these components, creating a common “pool of resources” that can be independently selected and allocated on demand to compose any infrastructure service. Key enablers for DA-RAN are 1) network ʽsoftwarizationʼ, migrating from the conventional closed networking model to an open reference platform, supported through 2) HW programmability, where HW is configured directly by network functions, to provide the required performance. This will enable provisioning of any service by flexibly mixing-and-matching network, compute and storage resources without sacrificing performance and efficiency as is the case in today’s NFV-based solutions.To validate these capabilities, 5G-PICTURE will demonstrate converged fronthaul and backhaul services in: a) a smart city environment, b) a 5G railway experimental testbed showcasing seamless service provisioning and mobilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Wind turbine blades End of Life through Open HUBs for circular materials in sustainable business models' (EoLO-HUBs) under Horizon Europe.

assistant: **Objectives**

A sustainable Circular Economy in the wind sector requires to solve the End of Life problematic of the Wind Turbine Blades, prioritizing environmental factors and fairly sharing the efforts to overcome the technologic, economic and social barriers among all the key actors. To this end, EoLO-HUBs will develop 3 open hubs to co-design, co-create and demonstrate new technologies, organizational structures, business models and legal recommendations to implement CE according to the needs of the different European regions. The Knowledge Hub will connect stakeholders to effectively collaborate on similar initiatives, sharing data and spilling over good practices to replicate success stories during and after the project. The other 2 hubs will build a large-scale demonstration covering the full value chain for WTB reusing and recycling from the dismantling to the valorisation in heavy composite sectors through efficient waste recycling solutions, while specific needs of EoL composites in wind technology are representing.  The Onshore Hub will include the necessity of implementing a Zero-pollution and mobile system for dismantling onshore technologies without jeopardise the environment and maximising the recovering of paints and coatings as well as enabling the recyclability of chemical building blocks (solvolysis). The Multi-sectorial and Offshore Hub will include the necessity of adapting current high volume composite recycling technologies (pyrolysis) to obtain a high yield of rGF and cGF in a Zero-waste approach collaborating with other sectors as well as to demonstrate how to prepare the gateways for offshore technologies to connect to the new value chain for recycling WTB. In this way, EoLO-HUBs will create a long-term collaboration of key actors with access to relevant dem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The capacity of civil society organisations (CSOs) and their networks in community based environmental management'.

assistant: **Objectives**

The CiVi.net project aims to analyse, transfer and disseminate successful and sustainable community based solutions with regard to ecosystem service management in Latin America. The main focus is placed on institutional settings in terms of original rules and related governance models which help to prevent and resolve tensions arising from a necessary new repartition and use of natural resources. Thereby, the role of civil society organisations (CSOs) within these governance models is in the core of the research. To meet these challenges, CiVi.net takes an action research and case study approach.The project has chosen four case study regions in Brazil and Costa Rica where successful solutions have been worked out. These will be analysed with respect to the following questions:- What kinds of management instruments are used to solve environmental problems and how effective are they?- What kinds of original rules and institutional arrangements are implemented and which economic governance models have been established?- What crucial aspects must be considered when transferring these solutions to other communities that face similar problems?- What is the capacity of CSOs and their networks for contributing to finding, implementing and transferring such solutions?Based on the findings, CiVi.net wants to facilitate the transfer of successful solutions to at least one other community for each selected case study region confronted with similar environmental challenges. To do so, CiVi.net will develop an ex-ante assessment approach to test the transferability of institutional solutions and of successful governance models. One of the final outputs will be a manual to assist practitioners and scientists on how to design and manage the knowledge transfer. CiVi.net will put much emp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Developing a 1.2 kW air-to-air single-room heat pump unit for heating, ventilation, and air-conditioning' under Seventh Framework.

assistant: **Concept**

We, EU HVAC industry AGs, represent the interests of more than 4,900 SME firms active in installation, commissioning and maintenance of heating, AC, and ventilation devices, are under threat from upcoming EC regulations (expected full compliance by 2015) to phase out such devices that are non-energy efficient, noisy, non-aesthetic and contribute to CO2 generation. These regulations are Directive 2004/8/EC (amending Directive 92/42/EEC) and Directive 2002/49/EC. The European Commission is EN ISO 13790 standard for AC and heating systems and for ‘Calculation of Energy Use for Space Heating' in buildings. EC regulations call for phasing out AC, ventilation and heating systems that do not meet ecological requirements, complying with the EPBD and EU phase-out of HCFC by 2015. Our industry has to conform with Directives 2002/95/EC and 2002/91/EC on aesthetic nature of the buildings while the majority of our technologies are split heat pump devices which require a large external heat exchanger on the ground or in the air. Our members therefore require a small modular heat pump technology which can be simply retrofitted into any room of a domestic home or building. We must research and develop the next generation of modular, air to air source heat pumps intended for single-room applications. The retrofit technology will provide local control of heating, cooling and ventilation with a wireless central monitoring station. New scalable heat pump should be able to achieve a superior 4.7 COP rating, a very low external noise level of 35db and a low price point as well as optimal life-cycle cost regime. This project will also cover the requirement for new ventilation systems, which are not based on exploiting exhaust air. Our proposed heat pump will provide ventilation and improve bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Exceptional Quantum Gravity'.

assistant: **Innovation**

Motivated by the overwhelming success of symmetry concepts in formulating basic laws of physics, the present proposal (eQG) seeks to develop a new symmetry based approach to the problem of reconciling Quantum Mechanics and Einstein’s General Relativity into a consistent theory of Quantum Gravity, regarded by many as the greatest challenge of contemporary theoretical physics. The need for such a theory is most pressing for the resolution of black hole singularities and the Big Bang, but it is equally crucial to the search for a consistent UV completion of the Standard Model of Particle Physics and the unification of the fundamental interactions. eQG aims to tackle this problem from a new perspective, bringing together very different strands of development: on the one hand, by paying particular attention to recent advances in our understanding of cosmological singularities and the evidence for novel infinite-dimensional duality symmetries near the singularity that has emerged in supergravity and string theory, and to recent progress in formulating ‘exceptional geometries’ transcending Riemannian geometry; on the other hand, by exploiting insights from modern canonical quantisation towards a better understanding of the basic degrees of freedom and the dynamics of quantum space-time. The main focus of eQG will be the ‘maximally extended’ exceptional hyperbolic Kac–Moody symmetry E10, whose uniquely distinguished status makes it a prime candidate symmetry for unifying the known dualities of string and M theory, for a conceptually precise scenario of emergent (quantum) space and time near the singularity, and finally, for replacing supersymmetry as a guiding principle for unification. Consequently, the principal goal of eQG will be to explore how this symmetry can define a th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Feedback-control of the Microenvironment: Modular Organ-on-Chip Technology to elucidate the role of Neurovascular Stress in Schizophrenia' (CHIPzophrenia).

assistant: **Innovation**

A well-controlled microenvironment is paramount for reproducible biomolecular studies. Organs-on-chips are in-vitro cell culture systems that employ microfluidic and biomaterial engineering towards that goal. They combine the advantages of animal models (physiological environment) with those of plastic-dish culture (human cells), and thereby hold exceptional promise in unraveling the biological processes that underlie health and disease. Yet control over the biochemical environment remains poor.With CHIPzophrenia, I propose to develop a new generation of organ-chip, one that features feedback-enabled control of the biochemical environment. I aim to realize dynamic and well-controlled application of stable therapeutics (via feedback sensors and flow control), and crucially also of highly volatile oxygen/nitrogen stressors by relying on electrochemistry to generate them in situ. My goal is to moreover implement a highly functional modular architecture so that the system can easily be repurposed and sensor/control modules reused – all with negligible dead volumes and displacement (key challenges in current organ-chips towards novel functionalities).I intend to leverage this organ-chip to elucidate how nitrosative stressors disrupt the complex multicellular interactions of the blood-brain barrier, where existing in-vitro models fail to provide the requisite cellular and chemical microenvironment. Yet such disruption is implicated in a wide array of disorders – including schizophrenia, where our biological understanding remains poor and in-vivo models are uniquely challenging. I will specifically test the hypothesis that nitrosative dysregulation of perivascular cells plays a causative role in neuronal dysfunction associated with the disorder. Not only will CHIPzophrenia thu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spectrum and energy efficiency through multi-band Cognitive Radio' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

As highlighted in the Work Programme, energy efficiency and flexibility in the use of spectrum resources are two major research challenges for the development of future wireless communications technologies.<br/>To address these challenges, SACRA project proposes to develop a multi-band cognitive radio technology. In SACRA, new techniques for the global efficiency of wireless systems will be developed in the following four directions:- the spectral efficiency thanks to the use of cognitive radio techniques in a multi-band scheme,- the minimization of electronic component number in wireless systems,- the energy optimization for wireless communication terminals by optimizing architecture design and algorithms implementation,- the minimization of the generated interference in the environment by selecting the adequate band which will guarantee the shortest transmission distance and the minimum power while preserving the QoS.<br/>The innovation and impact brought by SACRA project are in the combination of innovative approaches on Radio Frequency (RF) front-end and base band components design with new cognitive radio techniques integrated into a demonstrator platform. The major outcome of SACRA project is a proof-of-concept able to communicate jointly and cognitively in two separate frequency bands, which corresponds to concrete needs today in Europe. The initial target scenario is the management and optimal distribution of broadband mobile communications on two separate frequency bands at 790-862 MHz and 2.6 GHz as proposed by European regulation authorities.<br/>Considering the current ICT challenges, SACRA project, by designing and validating new techniques for spectrum and energy efficiency in wireless communications, is expected to have a significant impact on future  wir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Density functional theory of polyelectrolytes' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The project is concerned with the description ---based on density functional theory--- of polyelectrolytes. We propose to focus on the poorly understood but important effects of co- and counterion correlations near the (highly charged) surface of the mesoscopic (colloidal or polymeric) polyions. We plan to apply concepts and ideas from systems like electrolytes, molten salts near solid surfaces, and confined fluids, and hence to bring together the theoretical description of several subareas in liquid- state physics. In addition, once the correlation effects have been described realistically, they can be incorporated effectively in a phenomenological theory, from which reliable explicit predictions of the structure and phase behaviour of polyelectrolytes can be made. Training content (objective, benefit and expected impact) The applicant has a background in the theory of bulk liquid crystals and magnetic colloids. This project gives him the opportunity to leam about the effects of (i) high charges on the particles and (ii) surfaces and interfaces. These effects are not only scientifically fascinating but also relevant in many applications. The combination of his current background with the proposed project will give the applicant an excellent overview of the broad field of complex fluids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '4-IN THE LUNG RUN: towards INdividually tailored INvitations, screening INtervals, and INtegrated co-morbidity reducing strategies in lung cancer screening' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With 338,000 EU-deaths annually, lung cancer is a devastating problem. CT screening has the potential to prevent ten-thousands of lung cancer deaths annually. The positive results of the Dutch-Belgian screening trial (NELSON), with relatively low referral rates, and the NLST in the USA provided conclusive evidence. However, implementation is likely to be limited, slow and of variable quality throughout Europe, and current guidelines could easily require up to 25 million CT screens annually. The most optimal strategy in risk-based lung-thoracic screening is still unknown regarding the optimal and most cost-effective (e.g., targeted) strategy 1) to recruit, 2) to integrate smoking cessation and co-morbidity-reducing services, and 3) to determine the (risk-based) screening interval. Personalised regimens based on the baseline CT result can potentially retain 85% of the mortality reduction achievable through screening at 45% less screens, thus potentially saving much unnecessary harm associated with screening, and 0.5-1 billion Euros per year. The heart of 4-IN-THE-LUNG-RUN is a randomised controlled trial amongst about 24,000 individuals evaluating whether it is safe to have risk-based less intensive screening intervals after a negative baseline CT. Various methods to improve participation of hard-to-reach individuals will be assessed in five different healthcare settings. Innovative co-morbidity reducing strategies will be tested including other markers on CT imaging, as Calcium Score and COPD. Cost impact and cost-effectiveness analyses using a natural history model will steer implementation. The experienced consortium will strongly interact with key stakeholders, and discuss interim results with key other international initiatives on CT screening, biomarkers, and smokin