RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Econometric investigation of optimal exercice in American option pricing models - estimation and tests'.

assistant: **Innovation**

One of the most important issues in American option pricing is to find an optimal exercise strategy, i.e. a time t such that, when the option is exercised at t, the expected discounted payoff of the option is maximised. For some dynamic specifications of the underlying asset price, a characterisation of optimal exercise can be made in terms of an exercise boundary: the optimal strategy consists in exercising the option at the first crossing of the boundary by the underlying asset price. The objective of the project is to derive econometric techniques for estimating the frontier. Several approaches will be considered, depending on which assumptions are made on the underlying dynamics. We will consider parametric estimation where some estimates of the dynamics coefficients are used as the true value in the calculation of the boundary. Non parametric estimation of stochastic frontiers will also be performed. Simulation procedures will be used for assessing thus distributional properties of our estimates. Finally, we will propose a test of the pricing model based on a comparison of different estimators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Localisation by nonlinearity and spatial discreteness, and energy transfer, in crystals, biomolecules and josephson arrays' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

We will hire 309 post-doc months and 20 pre-doc month of young researchers in our laboratories and train them in the art of interdisciplinary research combining rigorous mathematics, theoretical physics, experimental physics, chemistry, molecular biology, scientific computation and data analysis. In addition, we propose to put on a series of schools and workshops on the themes of this research project, with application for attendance open to all interested young researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regeneration of Injured Spinal cord by Electro pUlsed bio-hybrid imPlant' (RISEUP).

assistant: **Concept**

Spinal Cord Injury (SCI), a major cause of paralysis, currently has no effective therapies. Every year almost 500.000 people are diagnosed with SCI worldwide. In Europe, the average investment is up to 2 M€ per patient in health care. The difficulty on the neuronal restoration after SCI is based on the complex cascade of events that inexorably cause a degenerative chronic stage mainly favored by the non-permissive environment and limited capacity for axonal regrowth. Multifaceted strategies are considered the unique solution for functional restoration by including cell substitution, neuroprotection and axonal growth promotion. RISEUP proposes to attain neuronal functional regeneration after SCI by an unprecedented and unique bio-hybrid-compatible electro-activated and wireless-rechargeable implantable technology. RISEUP introduces high voltage microsecond electric pulses (micropulses) stimulations and low amplitude direct currents on a combination of stem cells (induced neural stem cells and multipotent stromal cells), whose transplantation is facilitated by an innovative scaffold biomaterial. The RISEUP concept is that micropulses, being able to impose and control cytosolic Calcium oscillations, will facilitate cell maturation, survival and neurotrophic factors secretion. Because Calcium signaling is essential for neuronal activity, endogenous neuronal re-connections will also be favored. RISEUP goal, even if ambitious, is concrete due to the multidisciplinary partners’ competences, initiating from TRL1 a radically new line of technology (electro-activated, remotely controlled, biocompatible, biodegradable cell-containing implants for the repair of neuronal lesions) establishing its proof-of-principle (TRL3). The long-term vision of RISEUP is the radical change in SCI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quantitative Surgical Guidance for Colorectal Surgery using Endogenous Molecular Contrast' in the context of a Horizon 2020 call.

assistant: **Objectives**

Despite significant advances in medical imaging technologies, there currently exist no tools to effectively assist healthcare professionals during colorectal surgery. Surgeons mainly rely on their own senses, vision and touch to identify diseased tissue that should be removed or healthy tissue that should be avoided. In turn, surgery remains subjective and dependent on the experience of the surgeon, resulting in unacceptable failure, recurrence and morbidity rates, as well as in significant quality of care disparities across hospitals.The hypothesis underlying our study is that near-infrared light travels deeply into living tissues and interacts with endogenous molecular constituents, namely oxy- and deoxy-hemoglobin, water and lipids, providing key information regarding tissue perfusion, oxygenation, hydration and metabolism. In turn, such information can be used to differentiate diseased from healthy tissue. We recently introduced a novel concept that enables the quantitative imaging of endogenous molecular information over large fields-of-view. Because this concept can be implemented in real-time, it is amenable to provide video-rate endogenous information during colorectal surgery. In this study, we propose to push the limits of this concept by developing ground-breaking theory & technology, and creating a novel surgical guidance device capable of real-time imaging of key endogenous information for colorectal surgery. Correlation between endogenous contrast measurements and histological tissue status will be investigated onto bowel ischemia and colorectal cancer animal models. Finally, a clinically-compatible imaging device will be fabricated and translated into a first-in-human study in patients undergoing colorectal surgery. If successful, this study has the poten
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Beyond the bandgap: HyperSpectral image sensors from ultraviolet to infrared' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In this ERC Proof-of-Concept project we will create a high-performance and scalable platform for spectrally resolved imaging in a highly compact on-chip device structure. This new concept for a hyperspectral imaging system will exploit three key outcomes of my ERC Starting Grant: (i) photoconductivity phenomena in semiconductor nanowires, (ii) high-throughput characterisation techniques for individual nanostructures and (iii) automated adaptive manufacturing processes for building functional nanostructure-based devices and systems. This hyperspectral imaging array will be a powerful demonstrator of the scalability and throughput of our adaptive manufacturing platform. It will unlock a new low-cost, portable, scalable and on-chip hyperspectral imaging technology that propels the diverse applications of hyperspectral imaging spanning point-of-care medical diagnostics, environmental monitoring, industrial process monitoring, materials inspection and beyond
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Simple Atto Molar Detection and Nanoscale Kinetics of Biomolecules' under Seventh Framework.

assistant: **Concept**

Single Nano-Particles undergoing Brownian motion in solution colliding at an inert ultramicroelectrode, can serve as nano-electrodes during the time of contact. This provides an entirely new approach to nanoelectrochemistry. Hitherto, this new technique has been used for understanding simple redox reactions. We propose to experimentally study the electron transfer kinetics of single redox active proteins under steady state diffusion conditions, in this elegant configuration. In this way realistic mimicking of electron transfer based natural events will be achieved. In addition, the fundamentals of biological electron transfer will be revisited and re-evaluated. In parallel to this, we plan to use the natural redox activity of selected amino acids within a protein to establish a simple type of biosensor, with approximately attomolar detection sensitivity for label free proteins. Recently, the ability to observe electrocatalytic activity of single NP’s (due to collision with an electrode) was established. In the same way, we plan to use proteins as nanoparticles for biosensing applications. By immobilizing specific aptamers on an inert substrate, the absorption of label free proteins on top of the aptamers will be tracked. Chronoamperometric profiles measured on ultramicroelectrode under potential control should allow detection of attomolar concentrations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative Antibiotics to target drug-resistant microbes' under Horizon 2020.

assistant: **Concept**

Antibiotic resistance has become a major public health threat in Europe and the United States where resistant bacteria are directly responsible for ten of thousands deaths per year. The D_Bug project aims to develop innovative antibiotics to target drug-resistant microbes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Technical assistance to Slovak SMEs in proposal preparation' to be submitted under Sixth Framework.

assistant: **Abstract**

SMEs in Slovakia are the cornerstone of the Country's competitive position and job creation. They are confronted by many specific challenges, among which:- new sub-contracting partnerships with large companies,- fast reaction capabilities in case of technological, political and business changes- new organizational concepts such as networked businesses.One of the main resources for improving sustainability and competitiveness of Slovak SMEs is their active participation in the 6th Framework Programme RTD projects. The main objective of the project is focused on assisting Slovak SMEs in the preparation of their proposals addressing Programme objectives and calls of the 6thFP. This objective shall be achieved by a selective and dedicated approach.The selective approach is based on the analysis of the current status followed by identification of Country specific areas for technology and innovation development. SMEs will be informed through repeated eight (8) Information Days" events and encouraged to address their project ides to these specific areas.For SMEs with sound project ideas, a dedicated proposal drafting five (5) "Trainings combined with workshops", addressing relevant 6thFP project instruments will be organized. As a result of this technical assistance, at least 25 eligible Slovak SME project proposals will be prepared and submitted during the duration of this SSA project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Analysis of the molecular mechanisms of antigen presentation to B cells by macrophages in lymphoid organs' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

B cell activation is triggered by antigen recognition through the B cell receptor (BCR). It has been evidently shown that the antigen encountered in vivo by B cells is mainly membrane-bound. However, the molecular events involved in the process of recognition are not yet undertaken. Dr. Batista’s lab has very recently shown that macrophages collect and concentrate particulate antigen at the lymph node, where it is then encountered and acquired by follicular B cells. So, the principal aim of this proposal is to investigate and define the molecular mechanisms that govern this novel way of antigen presentation to B cells, mediated by macrophages at the spleen and lymph node. To carry this out, we propose to investigate the macrophage membrane proteins involved in the antigen presentation, such as mannose receptor or SIGNR1 (murine homologue to DC-SIGN) and complement. These studies are likely to shed light into how B cell responses are initiated which direct implications in vaccine design and autoimmunity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Specificity of signaling through the common cytokine receptor y chain during early lymphoid development' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content ABSTRACT It is known that a variety of cytokines is involved in Iymphocyte development and differentiation, and that defects in the common cytokine receptor y chain utilized by IL-2, IL-4, IL-7, IL-9 and IL-15 results in abnormal Iymphoid development. Three major pathways have been identified following IL-2 binding to IL-2 receptor: l)the induction of proto-oncogenes c-fos and c-jun following pS61ck, 2)c-myc induction due to syk kinase activation, and 3)a pathway that increases bcl-2 levels. This project will attempt to identify the role of some of these signaling pathways to Iymphoid development, using theyc-deficient (y = gamma) mouse model, in vivo and in vitro. c-deficient hematopoietic precursors purified by cell sorting techniques will be transfered using retroviral infection with yc cDNA constructs. The modified precursor cells will be then placed either in defined in vitro culture conditions which flavor Iymphoid development or will be used to graft yc-deficient mice (in an attempt to reconstitute the Iymphoid system in vivo. Since yc cells fail to activate any of the above mentioned signaling cascade, by transducing yc chimeric cDNA molecules which can only associate or activate individual signaling pathways, we hope to define the roles of these various pathways for biologically relevant phenomena, in this case, Iymphoid differentiation.Training content (objective, benefit and expected impact) Our project will try to elucidate the yc receptor signaling pathways in the development of the cells which belong to the Iymphoid lineage, using the yc knockout mice and retroviral infection techniques. The applicant will acquire knowledge in the fields of biochemistry, cellular and molecular immunology. Links with industry / industrial rel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SURveillance Video Archives iNvestigation assisTant' (SURVANT) targeting Horizon 2020.

assistant: **Abstract**

All around the world, organizations and agencies deploy video surveillance to monitor and protect property and public infrastructure, driven by various factors like increasing crime rate, security threats, terrorism acts and even monitoring of law enforcement. The influx of surveillance footage from a growing number of cameras operating at higher resolutions, such as HD, coupled with the desire to increase the retention time of that footage is exploding the volume of the footage available. Organizations that have invested heavily in surveillance infrastructure are keen to exploit it for the automation of surveillance procedures using video analytics solutions.SURVANT will deliver an innovative system that will collect the relevant videos from heterogeneous repositories, extract video analytics, enrich the analytics using reasoning and inference technologies, and offer a unified search interface to the user. An intuitive interface with a relaxed learning curve will assist the user create accurate search queries and receive the results using advanced visualization tools. Ethical management of personal data collected from surveillance videos is integrated in the system design.SURVANT is the follow up of the research project ADVISE (GA 285024), co-financed by EU in the FP7 Work programme in the SEC-2011 call. It intends to market uptake the results achieved in ADVISE and prove the final system at operational environment (TRL9). The market opportunity has been confirmed during the ADVISE project demonstration workshops, where end-users were enthusiastic about the functionality of the prototype presented and some initial interest for purchasing the system was declared. Law Enforcement Agencies (LEAs), critical infrastructure operators and private security organizations are th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '6G-Multiband Wireless and Optical Signalling for Integrated Communications, Sensing and Localization' to be submitted under Horizon Europe.

assistant: **Abstract**

6G-MUSICAL is a ground-breaking project that merges radio sensing and communication technologies to create new paradigms in RF communication. It aims to equip edge infrastructure nodes of 6G with integrated RF/radar-based radio-sensing elements that co-work with communication components. This enables localization, object tracking and 3D imaging, with cm-level precision and resolution. As such, the project will investigate new spectrally and energy efficient system architectures and signals, to facilitate high-rate communication across multi-frequency bands integrated with accurate sensing and localization.Compared to other joint communication and sensing research, 6G-MUSICAL stands out in two ways. First, it considers sensing for both connected and non-connected objects, which is important given the trend towards connecting everything. Second, it addresses the synchronization of edge nodes, which is critical to achieving extreme levels of accuracy and resolution. The project will combine optical and electronic technologies to generate precise and stable references, enabling a network of smart cooperative multi-static radars, within future 6G, bringing new services, high accuracy localization and high-resolution 3D object reconstruction.In the wireless domain, the project will define new waveforms suitable for radio-sensing and communications, exploit compressive sensing techniques and define cooperative multimode sensing and localization algorithms. In the network domain, focus will be on procedures for synchronization/calibration among edge nodes and on compression techniques to enable low overhead transport to a data fusion center of the collected information. The optical/electrical technology will develop and distribute the reference signals and will create novel ant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multilingual access to data infrastructures in the European research area' under Fifth Framework.

assistant: **Concept**

The MADIERA project is addressing the part II of the IHP-KA1 by implementing an extensible and distributed multi-lingual web-based infrastructure for the European social science research community. It will benefit1) data archives and other information providers by delivering content publishing and management tools and creating exemplars;2) researchers, who will then be able use the tools to locate and browse distributed resources and then link their output dynamically to underlying data and other resources in focused information environments; and3) users of academic research who will be able to access, explore, challenge and interact with high quality research output.The project will deliver these benefits by exploiting advanced software to publish heterogeneous data sources interactively and integrate them with other resources and knowledge products through a Web-based infrastructure populated with a variety of data and knowledge products from a wide selection of European providers.