RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Automated Microhandling System for X-ray Crystallography'.

assistant: **Innovation**

Crystallography is one of the most important methods for studying the 3D structure of complex biological macromolecules. The knowledge of the detailed structure of proteins, enzymes and chromatin allows scientists to understand concepts such as bimolecular interactions, mechanism of enzymatic catalysis and the therapeutic action of drug molecules. A major bottleneck of high-throughput crystallography is harvesting the crystallized form of these molecules from their liquid environments and manipulating them to a location that enables exposure to the X-ray beam. Due of the fragility and large size range of crystals this step has so far been done manually by trained experts.The proposed research will advance the concept of using a wireless, magnetically driven microrobot, named the RodBot, for micromanipulation of delicate biological entities. The RodBot rolls on a supporting surface in a low Reynolds number fluidic environment and generates rising flows in front of it, and a vortex above it. The flows are utilized for noncontact micromanipulation of fragile objects such as protein crystals. As the RodBot approaches a micro-object, the object comes under the influence of the rising flows which lift it off the substrate. The suspended object is then trapped in the vortex and can be transported to a pre-defined location. The RodBot is powered and controlled by external, low intensity magnetic fields which are generally harmless to living organisms and can readily penetrate most biological material. The flows generated by the RodBot can precisely manipulate crystals of sizes varying from a few microns up to one millimeter. It is capable of separating individual crystals from a group and delivering it to an extraction device called the loop.The core magnetic manipulation techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integration of information about macromolecular structure' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The aim of this proposal is to develop a prototype system that will integrate data about macromolecular structure at low resolution from three dimensional electron microscopy (3D-EM) with data at atomic resolution from X-ray and NMR techniques .The prototype system will interface with the existing European MacromolecularStructure Database (EMSD) resource under development at Partner 1's site to store data about X-ray and NMR structures. In order to improve the usefulness and consistency of data from 3D-EM, validation issues in 3D EM will be addressed forth first time and software developed assesses the quality and consistency of data from 3D-EM techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Bodies across borders: oral and visual memory in Europe and beyond'.

assistant: **Objectives**

This project intends to study intercultural connections in contemporary Europe, engaging both native and ‘new’ Europeans. These connections are woven through the faculties of embodied subjects – memory, visuality and mobility – and concern the movement of people, ideas and images across the borders of European nation-states. These faculties are connected with that of affect, an increasingly important concept in history and the social sciences. Memory will be understood not only as oral or direct memory, but also as cultural memory, embodied in various cultural products. Our study aims to understand new forms of European identity, as these develop in an increasingly diasporic world. Europe today is not only a key site of immigration, after having been for centuries an area of emigration, but also a crucial point of arrival in a global network designed by mobile human beings.Three parts will make up the project. The first will engage with bodies, their gendered dimension, performative capacities and connection to place. It will explore the ways certain bodies are ‘emplaced’ as ‘European’, while others are marked as alien, and contrast these discourses with the counter-narratives by visual artists. The second part will extend further the reflection on the role of the visual arts in challenging an emergent ‘Fortress Europe’ but also in re-imagining the memory of European colonialism. The work of some key artists will be shown to students in Italy and the Netherlands, both recent migrants and ‘natives’, creating an ‘induced reception’. The final part of the project will look at alternative imaginations of Europe, investigating the oral memories and ‘mental maps’ created by two migrant communities in Europe: from Peru and from the Horn of Africa.Examining the heterogeneous mi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Learning from long-Term Care practices for the European Care Strategy' (LeTs-Care) under Horizon Europe.

assistant: **Objectives**

European societies find themselves in a window of opportunity for the advancement of LTC policies and practices. The pandemic has made clear that there is a need for accessible, affordable and quality services, more equality, protection and inclusion for people in need of care, informal caregivers and care workers, and sustainability. To meet these goals, policy makers, stakeholders and researchers need to comprehend the challenges ahead, the patterns and drivers of inequalities in LTC, the potential contribution of emerging practices and the development of contextualised sustainable practices. LeTs-Care originally combines an ethnographic approach with the analysis of territorial indicators and fuzzy-set/Qualitative analysis to provide a new, in-depth, reflexive understanding of LTC challenges and their diversity across 7 European countries. It will disentangle the meanings of taken-for-granted LTC concepts and illuminate how , e.g., “care” or “integrated care” have different meanings in different contexts. It will produce new evidence and a novel approach to territorial inequalities in LTC, their drivers and interdependencies. The project will conduct 18 ethnographic studies or care practices aimed at improving the wellbeing of care receivers, of care workers and of informal caregivers: ethnographic case studies will comprehend the tensions, trade-offs and choices that underpin these practices and will develop context-sensitive policy recommendations.  Finally, LeT’s-Care will move beyond “best practices” by developing a new, reflexive approach to policy learning and a concrete toolkit. LeTs-Care is based on a strong and diffuse partnership between academic institutions and key LTC stakeholders and policymakers that allow the coproduction of knowledge, enhances the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Specialised Cell Carrier Components'.

assistant: **Innovation**

Silicone offers significant advantages as a 3D cell scaffold, essentially a 3D microtissue device.  These benefits include a capacity for variable porosity, variable open pore volume for cell entrapment, variable density for fluidisation,  variable geometry, friction resistance, and low toxicity. The lead SME partner Cellon SA holds the IP for porous silicone carriers (Immobasil), which met some of these criteria, but exhibited poor cell adherence and requires re-engineering and exploitation of current cell biology knowledge and applications. There  is a strong commercial need for such  fully functional 3D cell culture technologies (microtissue) that can be manufactured into robust  and reproducible in vitro test systems for toxicity testing,  drug testing,  cosmetic testing  as part of a projected €1.6b  cell based test market.This technology developed maybe suitable as an active component in bioartificial livers (BAL) and other bioartificial organ devices. The market growth is driven by needs in drug screening for drug discovery and toxicity screening. There are also a number of current  EU directives that is driving the demand for reliable in vitro 3D cell based test system to replace in vivo test systems. The bio artificial liver market is also expected to grow rapidly due to high rates of liver disease worldwide.The objectives will be to deliver:1) Immortalised hepatocyte and endothelial cells that retain characteristics of primary liver cells in 3D co-culture.2) An improved  porous silicone carrier for 3D culture of these cells (cell-carrier component)3) A  prototype fluidized bioreactor bed for culture of these cell carrier components.4) Cell carrier component tested in a microwell plateThe results of this project could  form the basis for subsequent (following t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'System-on-Chip Millimeter-wave Radiometers for Space-based Detection of Solar Flares' (FLARES), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the research fellowship project FLARES is the study, analysis, design, development and experimentally characterization of millimeter-wave system-on-chip radiometers for space-based detection of solar flares. This approach will contribute to reduce significantly the power consumption and weight with respect to the existing instruments for the observation and study of solar flares. The choice of the operating frequency of 35 GHz is due to the following three reasons. First, a miniaturized SoC instrument can be realized with present microelectronic technologies, which are now mature for this region of spectrum. Second, assuming a space-based operation of this instrument, an unprecedented sensitivity limit can be achieved, allowing for the detection of weak events non detectable with the existing observation instruments. Third, this approach will meet the low cost, low power consumption constraints approach required by LEO satellites. It is worth mentioning that the same methodology developed in this project could be then applied to the 90-100 GHz band as soon as space-qualified silicon technologies will be available in the next years for that region of spectrum.This is the first time that the level of integration proposed by FLARES will be achieved. The published receivers do not integrate the digital section, thus they don’t allow for the application of the radiometer to a real world scenario. In particular the video amplifier and ADC sections have never been included in a SoC radiometer. These sections will allow for the first time, a complete and accurate calibration of the instrument. Moreover, it is the first time that a space qualified technology will be used to implement a complete SoC radiometer.The dramatic weight reduction that will follow from t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing a robust decision making framework for climate change policy under uncertainty' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Although the EU is on track to achieve the climate targets of “20-20-20”, there is an ongoing debate over whether a more aggressive emission reduction goal is needed to be set for 2030. The root cause of such debate is not only the lack of scientific understanding of climate change but also severe uncertainties about the pace of change and the extent to which it impacts human and natural systems. The policy implications of climate change uncertainty depend on the proper treatment of uncertainty in integrated assessment models (IAM) of climate change. There have been several attempts to incorporate uncertainty in standard IAM frameworks but the results vary widely across the models. This is in particular important for implementing effective mitigation and adaptation strategies within the EU which require a great deal of coordination among the member states with different levels of economic development and political incentives. The objective of this research is to develop a framework for robust climate policy making under uncertainty. During the first stage of this project I will conduct a through survey of current treatment of uncertainty in standard IAMs to obtain the best practices. In the second stage, I will develop a unifying framework for analyzing decision making under uncertainty in the context of climate change. I will adopt a robust optimization approach to assess climate targets and the optimal pathway to achieve those objectives. This theoretical framework then will be applied to the current and future EU climate targets and the results will be illustrated for climate policy making in Italy as a key Member State.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From Immune Responses in Rare Autoimmune Diseases to novel Therapeutic Intervention Strategies-a personalized Medicine approach' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The European research network, AUTOROME, represents Centers of Excellence in Europe where recent technologies in studying the pathophysiology of humoral and cellular autoimmunity are combined and applied to improve in a personalized manner diagnosis and treatment of rare human autoimmune diseases such as e.g. sclerodermie, systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), systemic vasculitis as well as autoimmune lymphoproliferative syndrome (ALPS). Rare Autoimmune diseases are associated with substantial morbidity and even accelerated mortality in affected persons (children and elderly) Combined efforts will be undertaken to explore the disease potential of pathogenic autoantibodies that might be involved in determining disease-related organ specificities. The AUTOROME project (www.autorome.com) is divided into 4 workpackages. These are Autoantigen and Autoantibody Mapping (WP1), Isotype-specific peptides (WP2), Dysfunction of the Immune System (WP3), Basic Developmental Mechanisms of the Immune System (WP4), By characterizing epitope-paratope / antigen-antibody interactions diagnostic tools will be generated to study in a personalized manner the pathogenicity of rare autoimmune diseases due to individual autoantibody signatures on a patient to patient basis. Deliverables (D1-D12) include diagnostic kits as well as autoantigen and antibody chips to be developed and validated in clinical settings. By deciphering the B- and T-cell repertoire displayed in autoimmune diseases, novel cellular targets are expected to become available for therapeutic intervention strategies using idiotype-specific peptides as well as therapeutic antibody and siRNA approaches. The feasibility of these approaches will be preclinically assessed in animal models - a prerequisit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Electronic sensor system for the characterisation of packaging emissions'.

assistant: **Objectives**

The ESCAPE project focuses on new quality control procedures in the food packaging industries. An existing hybrid gas sensor system will be coupled with appropriate sampling set-ups . The latter have to be optimised according to applications in the field of packaging materials. During the course of ESCAPE a dedicated system will be set-up. Within the ESCAPE Project the systems will be tested in different development phases in order to assess the quality of wrapping materials influenced by chemicals remaining from the production process which are potentially transferred in the food chain. The measurements of this new approach will be performed at- or on-line at an early stage of the converting and packaging process, respectively to avoid time-consuming analyses of the final products. Besides the time advantage resources will be saved since the whole manufacturing is already monitored at the very beginning.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revealing hadronic effects in B-meson decays' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Indirect New Physics searches are becoming increasingly important in the quest for physics beyond the Standard Model (SM). Since these heavily rely on the precision that can be obtained both in theory and in experiments, being able to achieve good control over non-perturbative effects, which are usually the main source of theoretical uncertainty, is of utmost relevance. With this postdoctoral fellowship, I will perform a comprehensive study of non-factorisable soft-gluon contributions in B-meson decays, focusing on the tree-level non-leptonic decays like $\bar B^0 \to D^+ K^-$, and on the rare semileptonic decays like $B_s \to \phi \ell^+ \ell^-$. In fact, for both types of processes, several tensions have been observed between the SM predictions and the corresponding data, and for both types of discrepancies, the dominant source of theoretical uncertainty stems from hadronic effects. Specifically, the computation will be performed using the well-established framework of light-cone sum rules (LCSR), employing the light meson (\pi,\phi, K^{(*)}) light-cone distribution amplitudes (LCDAs). The proposed project will represent the first calculation of these hadronic effects within this method and will make it possible to circumvent current challenges that arise when using B-meson LCDAs. Furthermore, particularly for the rare semileptonic decays introduced above, this approach will lead to a significant reduction of the theoretical uncertainties, as local and non-local form factors will be computed within LCSR using the same inputs. Therefore, the proposed research will be of considerable help in assessing the nature of the observed tensions and ultimately in exploiting the rich amount of future data available.


**Keywords:** B-physics, light-cone sum rules, hadronic effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Phenomenology of Heavy Ion Collisions at RHIC and the LHC' (HICATLHC) under Seventh Framework.

assistant: **Objectives**

Relativistic heavy-ion collisions probe the fundamental structure and behaviorof matter at the highest temperatures ever achieved.  Results from theRelativistic Heavy Ion Collider (RHIC) have demonstrated the creation ofa strongly interacting, deconfined Quark-Gluon Plasma (QGP).  New data, especiallyfrom higher-energy collisions at the Large Hadron Collider (LHC) will soonprovide an opportunity to quantify properties of the QGP medium, as wellas to characterize the non-equilibrium dynamics of the early stages of a collision.It is proposed to use state-of-the-art phenomenological tools to extract suchprecise quantitative information from these new experimental data.