RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Signaling decoded in ENhanCEr states – a molecular basis for plasticity in development and differentiation' (SENCE).

assistant: **Innovation**

Transcription is regulated by transcription factors (TFs) bound at enhancer elements located long-distances from the genes they regulate. How does this account for dynamic responses to the environment via signaling? Canonical views invoke signal induced changes in TF expression/modification or cofactor localization, but here we suggest that TF occupancy could be present before and after the signal, establishing competence, ensuring plasticity and blocking premature commitment. For ERK signaling, a central regulator of embryonic stem cell (ESC) differentiation, we found enhancers were regulated via selective recruitment of RNA Polymerase II (RNAPII) and associated cofactors. In this case, TFs do not play a direct role in enhancer regulation, but safeguard future activation in response to changes in signaling. In the context of developmental biology this paradigm could explain the dynamic nature of cell specification in the early mammalian embryo. In this proposal, we seek to understand enhancer specific regulation by ERK, exploit our ability to manipulate ERK to disentangle mechanism and focus on preimplantation development to explore how these phenomena explain plasticity. To circumvent heterogeneity created by feedback inhibition we developed a unique ESC line for cell intrinsic and synchronous ERK induction. We combine these ESCs with rapid TF degradation mutants to isolate homogeneous cell states that can be exploited to generate unique datasets and identify key factors within ERK response. We address how coactivator phosphorylation promotes selective recruitment of Mediator/RNAPII, explore the fundamental nature of enhancer activity and ask how uncoupling of transcriptional regulation from TF binding underpins developmental plasticity. By exploiting our capacity to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Genetic regulation and functional relevance of maize starchy endosperm programmed cell death' in the context of a Horizon 2020 call.

assistant: **Objectives**

Around 60% of our daily diet is directly derived from cereal grains. In the grain, most nutrients are stored in a highly specialized reserve tissue called the starchy endosperm (SE). SE development ends by the execution of a controlled cell death program (PCD), which leaves the nutrient-filled cell corpses largely intact. PCD has been proposed to be crucial for storage compound preservation, but despite this potential importance, surprisingly little is known on the genetic regulation of SE PCD. In this project, I hypothesise that cereal SE PCD is controlled by a gene regulatory network that I propose to investigate in maize (Zea mays). To this end, I will combine the extensive knowledge I acquired during my PhD on maize kernel development with the well-documented expertise of the host lab in plant PCD analysis. I will first determine the spatio-temporal pattern of SE PCD under the growth conditions of the host institute and characterise its subcellular features in detail by ultrastructural analyses. As SE PCD is not executed homogenously in time and space, I propose to perform then a single-nucleus RNA-seq combined with a spatial transcriptomics approach on dissected endosperm tissue in order to obtain transcriptome profiles and developmental trajectories with single-cell resolution. Based on their expression profiles, I will finally select up to 20 PCD-associated candidate transcription factors and screen them for gain-of-function PCD phenotypes in transient expression systems. Promising candidates will be functionally analysed in maize SE via gain- and loss-of-function approaches. In the resulting maize lines, I will investigate the changes in PCD progression and use them to assess the physiological relevance of a correct PCD execution in the SE. In sum, this project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Women’s movements and gestational surrogacy: engaging, debating and policy making' (WoMoGeS).

assistant: **Innovation**

Gestational surrogacy (GS) is transnational practice of assisted reproduction increasingly undergone by European citizens in Member States and Third Countries. Women’s Movements (WMs), primary actors in  policies on human reproduction, understand GS either as a form of commodification of women and children, or as an empowering opportunity for women in poor countries. WMs are forging alliances with other stakeholders (LGBTQI, pro-life, and private actors) to influence decision makers to abolish or to regulate GS. WoMoGeS analyzes the ‘politics of signification’ on GS of WMs in 2 developed countries, US, and Italy, and 2 developing countries, India and Mexico, to reveal variety of diagnostic, prognostic and motivational frames, their policy demands and strategic alliances across different social contexts, and the interplay between discourses and policy making at country-level and transnationally. By carrying out a comparison of 4 context-specific case-studies and engaging WMs and GS stakeholders, this project aims to hinder the risk that GS activism reproduces the same polarizing dynamics as in the debate on prostitution, and the risk that WMs’ perspectives in developing countries, main providers of surrogate mothers, are silenced by more visible WMs in developed countries. WoMoGeS aims to promote dialogue between WMs and GS stakeholders, catalyze European policy making on GS that considers diversity of thought, and to propose mature reflections on assisted reproduction based on scientific information. Training and supervision by top experts on GS at UT and on WMs at LUMSA will enable me to continue skill development started during my PhD on WMs’ contribution to gender-related discourses, strengthen my ability to work across different fields of Sociology, and acquire new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Protection against allergy: study in rural environments' under Fifth Framework.

assistant: **Concept**

In animals substantial prevention of allergy can be achieved by inhalation of microbial products. It is unknown whether such findings can be brought forward to humans, but findings in farmers' children raised in environments rich in microbial matter suggest that these children constitute an ideal 'natural' model to study these relations in humans. Recent retrospective surveys clearly indicated that exposures must occur in pregnancy and the 1st Year of life to confer significant protection, resulting in very low prevalence's of asthma (0.8% vs. 11.8%), hay fever (0.8% vs. 16.0%) and atop (8.2% vs. 32.9%) as compared to non-exposed children. The project therefore focuses on early life exposures to indoor microbial matter in a prospective study design. A multidisciplinary approach is taken to study immunological and genetic mechanisms determining the strong protective effects, which will allow the development of novel preventive strategies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Asset Management Integration of Cultural Heritage inthe Interexchange between Archives - The StoryboardExtension' (AMICITIA-SE) under Fifth Framework.

assistant: **Objectives**

The project includes a partner of the newly associated states (NAS) into an existing IST project (AMICITIA, IST-1999-20215). The new partner enhances the technological competence and the work force in respect to interactive and collaborative Internet / intranet technologies. The project proposed aims to develop and demonstrate a software component for the content management system developed by the AMICITIA project. This new component provides a collaborative facility to write, share and edit storyboards in conjunction with digital video archives. The project includes a partner of the newly associated states (NAS) into an existing IST project (AMICITIA, IST-1999-20215). The new partner enhances the technological competence and the work force in respect to interactive and collaborative Internet / intranet technologies. The project proposed aims to develop and demonstrate a software component for the content management system developed by the AMICITIA project. This new component provides a collaborative facility to write, share and edit story boards in conjunction with digital video archives.OBJECTIVESThe AMICITIA-SE project extends the existing AMICITIA project (IST-1999-20215)with a competent new technology partner from the newly associated states (NAS).AMICITIA-SE aims to develop, implement and demonstrate a storyboarding facility that extends the Content management system developed in the AMICITIA project. The storyboard extension provides a story-based collaborative retrieval and creation of media contents. The user is enabled to search, collect, annotate and arrange media objects from available archives in a collaborative, team-oriented way. Using collaborative internet technology the storyboarding extension makes full use of the distributed archiving features develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'REuse and Migration of legacy applications to Interoperable Cloud Services' (REMICS), addressing dissemination and exploitation.

assistant: **Impact**

The goal of REMICS is to develop advanced model-driven methodology and tools for REuse and Migration of legacy applications to Interoperable Cloud Services. Service Cloud paradigm stands for combination of cloud computing and Service Oriented Architecture (SOA) for development of Software as a Service systems.To support the migration, REMICS will enhance the OMG Architecture Driven Modernization (ADM) methodology with specific methods, metamodels and tool support, including knowledge discovery, patterns and transformations for SOA and Cloud Computing, Model-Driven Interoperability (MDI), Models@Runtime, Model Checking and Model-based Testing (MBT). REMICS will also link the extracted knowledge from legacy systems with requirements models outlining the application logic in the form of user-system interaction scenarios.REMICS will take an active role in the standardisation of metamodels and languages for Service Clouds including OMG PIM4Cloud/CloudML. The technical results will be compliant with the proposed standards ensuring high industry acceptance.The current migration approaches are mostly ad-hoc limiting EU companies from benefiting of latest Future Internet technologies for service provision. REMICS will provide the technologies that will shorten the time-to-market" and improve the manageability for service cloud systems based on legacy. Performance testing of applications in the cloud will enhance the runtime monitoring facilities and allow for optimization of cloud-based applications.REMICS tools and techniques will be supported by the REMICS methodology for migration, introducing relevant agile practices and agile method engineering principles.The REMICS consortium after extension consists of eight RTD partners and two SME users.  DOME and DI Systemer are two SM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Light-based functional in vivo monitoring of diseases related enzymes' (LIVIMODE) under Seventh Framework.

assistant: **Objectives**

LIVIMODE aims to develop specific tools for non invasive in vivo imaging of disease related molecular events. Such tools are of high relevance for disease detection, staging, developing animal models of human disease, and evaluating novel therapies. We propose to use optical imaging, which is optimally suited for this task as it provides excellent sensitivity and allows visualizing molecular events via a fluorescent signal. While optical imaging technology has rapidly evolved over the last years, the availability of SMART (activatable) imaging agents that change their fluorescence properties upon disease related events, remains a critical gap. The LIVIMODE project proposes to combine expertises in medicinal chemistry, pharmacology and imaging in a conceptually new approach in designing SMART agents. In particular, we will (i) translate established strategies in medicinal/pharmaceutical chemistry to design highly selective SMART probes and (ii) optimize the cell/tissue specificity of probes integrating concepts from polymer and protein based targeted drug delivery. We will generate a toolset of highly selective targeted SMART probes for at least 10 disease-relevant proteases. The selection of target proteases is based on their relevance in disease processes that cannot yet be monitored with non invasive technology. These include (i) the development of tumor microenvironment as a critical factor in oncogenesis, (ii) tumor hypoxia and angiogenesis, and (iii) inflammatory and degenerative processes in osteoarthritis. LIVIMODE has established animal models for these conditions and will use in vivo optical imaging to evaluate the novel SMART probes as tools for monitoring disease progression and drug efficacy. This will enhance our knowledge of disease mechanisms and our abil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Network Topology Complements Genome as a Source of Biological Information' (BIONET), addressing dissemination and exploitation.

assistant: **Impact**

Genetic sequences have had an enormous impact on our understanding of biology.  The expectation is that biological network data will have a similar impact.  However, progress is hindered by a lack of sophisticated graph theoretic tools that will mine these large networked datasets.In recent breakthrough work at the boundary of computer science and biology supported by my USA NSF CAREER award, I developed sensitive network analysis, comparison and embedding tools which demonstrated that protein-protein interaction networks of eukaryotes are best modeled by geometric graphs.  Also, they established phenotypically validated, unprecedented link between network topology and biological function and disease.  Now I propose to substantially extend these preliminary results and design sensitive and robust network alignment methods that will lead to uncovering unknown biology and evolutionary relationships.  The potential ground-breaking impact of such network alignment tools could be parallel to the impact the BLAST family of sequence alignment tools that have revolutionized our understanding of biological systems and therapeutics.   Furthermore, I propose to develop additional sophisticated graph theoretic techniques to mine network data and hence complement biological information that can be extracted from sequence.   I propose to exploit these new techniques for biological applications in collaboration with experimentalists at Imperial College London: 1. aligning biological networks of species whose genomes are closely related, but that have very different phenotypes, in order to uncover systems-level factors that contribute to pronounced differences; 2.  compare and contrast stress response pathways and metabolic pathways in bacteria in a unified systems-level framework and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Landslide and avalanchE Mechanics with Multiphysical datA' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Landslides and avalanches jointly cause approximately 150 deaths and 4.9 billion economic losses each year, with the impacts predicted to become more severe due to climate change. Mitigation and prevention of disasters requires accurate predictions of these phenomena, which due to their scale is only achievable via modelling and simulation. Accurate models of landslides in permafrost or avalanches must account for micro-scale (<1mm) processes such as cracks and shear bands that also involve thermal and hydrological effects that will be exacerbated by climate change. Such models do not currently exist. Further, this level of refinement is not computationally viable when modelling an entire mountainside, and so a new approach must be adopted.This project will: 1) Develop new models for permafrost and snow subject to climate-change-induced loadings; 2) Use the new data-driven mechanics framework to transfer information from these models to the scale of the mountainside; and 3) Simulate the effects of climate change on the Mont-Blanc massif at Chamonix. This will combine the researcher's experience with shear band models with the supervisor's expertise in crack models and optimisation techniques. A secondment at a group specialising in simulating landslides and avalanches will provide the expertise to implement the simulation on a real mountainside. This interdisciplinary project will ideally set the researcher for a career in academia in Europe, while benefiting the community at Chamonix, in particular the guide's association, as they will be able to plan adaptations and mitigations for the effects of climate change, ensuring their tourism industry remains viable. Specialised multiphysical models that are adapted to permafrost and snow will advance the state-of-the-art sig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Invigorating Enlargement and Neighbourhood Policy for a Resilient Europe' (InvigoratEU), addressing dissemination and exploitation.

assistant: **Impact**

“HOW CAN THE EU INVIGORATE ITS ENLARGEMENT AND NEIGHBOURHOOD POLICY TO ENHANCE EUROPE’S RESILIENCE?”. InvigoratEU aims at finding answers to this question by pursuing three overarching goals:Our first goal is (1) to investigate HOW TO REFORM the EU’s enlargement strategy in a new geopolitical phase, HOW TO RESPOND to other actors’ geopolitical ambitions in the Eastern Neighbourhood and Western Balkans, and HOW TO REBUILD the EU’s foreign policy arsenal in view of a new era of military threats (triple “R” approach) combining the modernisation and geopolitical logics of EU enlargement, leading to new data – e.g. a public opinion survey in Ukraine, a set of scenarios, an external influence index (Russia, China, Turkey), and a social policy compliance and cohesion scoreboard.Our second goal is (2) to elaborate an EVIDENCE-BASED, FORWARD-LOOKING VISION FOR THE EU’s POLITICAL AGENDA AND INSTITUTIONAL FRAMEWORKS FOR CO-DESIGNING A MULTIDIMENSIONAL TOOLBOX (i.e. two tailor-made toolkits), together with InvigoratEU´s Expert Hub, Civil Society (CS) Network, Youth Labs, Workshops for Young Professionals and Policy Debates in a gaming set up, which will result in context-sensitive and actionable policy recommendations for European and national political stakeholders and (young) European citizens in particular.Our third goal is (3) to deploy a CDE (communication, dissemination and exploitation) strategy AIMING AT RECOMMENDATIONS FROM DAY 1 to maximize our scientific, policy and societal impact in invigorating the EU´s enlargement and neighbourhood policies to enhance Europe´s resilience. ULTIMATELY, INVIGORATEU IS A DELIBERATELY LARGE CONSORTIUM respecting THE DIVERSITY OF EUROPE and POLITICAL PERSPECTIVES; 7 out of 18 are from GEORGIA, MOLDOVA, UKRAINE, and the Western Balkans (NOR