RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Coactivator-controlled transcriptional networks regulating skeletal muscle cell plasticity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Regular physical activity is linked to improved health and increased life expectancy. Inversely, a sedentary life-style is a strong and independent risk factor for many chronic diseases, including obesity, type 2 diabetes or cardiovascular disorders, as well as certain types of cancer or neurodegeneration. Interestingly however, the molecular mechanisms that mediate the health beneficial effects of exercise, or those that trigger the pathological changes in diseases, are largely unknown.The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is one of the major regulatory hubs of muscle adaptation to endurance training. Accordingly, elevated expression of PGC-1α in muscle is sufficient to induce a trained phenotype in mice. Inversely, mice lacking a functional PGC-1α gene in skeletal muscle exhibit many signs of pathological inactivity. Finally, PGC-1α expression is dysregulated in pathological contexts in human muscle, including type 2 diabetes and aging. Therefore, the study of the regulation and function of PGC-1α in muscle has the potential to yield important insights into the molecular mechanisms that control muscle health.Unfortunately, the characterization of PGC-1α is drastically hampered by the high complexity of the transcriptional network controlled by this coactivator protein, which binds to many different transcription factor binding partners in a cell context-specific manner. Moreover, PGC-1α seems to directly couple transcription to RNA processing, thereby further complicating the analysis of PGC-1α-controlled biological programs. Our proposal combines novel innovative experimental and biocomputational approaches with the physiological study of healthy and diseased muscle cells ex vivo and in different animal m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New therapeutic targets for osteoporosis and bone metastasis.' (1998-2002).

assistant: **Concept**

Bone is a dynamic tissue, which is constantly remodeled throughout life. Small shifts between bone formation and bone resorption lead to pathological situations. In osteoporosis and cancer-induced osteolysis, the excessive degradation of bone is due to increased osteoclast activity. The host institution uses target discovery to identify genes that are required in osteoclast function. Target discovery is a new interdisciplinary discipline involving molecular biology, bioinformatics, histology and cell biology. The host institution has already identified a series of genes that are up regulated during the formation or human osteoclasts in vitro. The aim of the present project is to establish the in viva expression of osteoclastgenes, and to assess their functional importance. The fulfillment of this aim requires a number of steps as explained in Form B4 (detailed proposal information: 3.1.2). More particularly, I will take care of the following tasks as integrated parts of the target discovery program.(1) I will use laser micro dissection microscopy to isolate single osteoclasts from human biopsies collected by the host institution, as well as from animal models for osteoporosis and bone metastasis currently used in the host institution.(2) I will use quantitative PCR to quantify accurately the expression of the genes that my colleagues will have selected through large scale gene profiling, bioinformatics and tissue arrays.(3) I will perform functional validation by using antisense, function blocking antibodies or viral transfection of osteoclasts, in different models that allow to evaluate the osteoclastic resortive activity and that have been developed in the host institution. The project is an opportunity to learn to work in a multidisciplinary program. I will become an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Crustacean prevention of melanosis and quality indices' under Fifth Framework.

assistant: **Concept**

The main technological problems that the proponents (crustacean fishing and trading companies) are facing are the quality problems in fresh and frozen products, mainly related with degradation of deepwater rose shrimp and discoloration and Melanesia of all crustacean captured or farmed. The main goals of the research project are the development of more efficient, alternative and safer products, particularly non-sulphite based, for treatment of crustaceanmelanosis; the development of tools (Aim's) for the rapid prediction of realistic shelf lives and risk assessment of the various crustacean; the determination of the most relevant quality indices for the quality assessment of crustacean; the reduction of the number of rejections, minimising microbiological hazards and development of much more cost-efficient quality assurance programmes; the significant improvement of the quality of crustacean landed by European Union vessels and increase of the proportion of crustaceans used for food.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mixed reality for upper-limb stroke rehabilitation' (StrokeCare).

assistant: **Innovation**

The recovery of the functional use of the upper limb is a main goal of rehabilitation in stroke survivors. Despite the development of many rehabilitation programs, upper limb paresis following a stroke still results in disability and a great societal cost. Attention deficits are also common in these patients. Here we propose two mixed-reality (MR) interventions to improve functional outcomes of the rehabilitation interventions as compared with classic rehabilitation programs. MR interfaces allow patients to use real world objects while interacting with virtual images, which enhances the use of real world objects. Virtual Reality allows recreating an ecological setting, which is key to the transfer of the rehabilitation outcomes. In the first intervention, patients will be able to train with real and also the same virtual objects and that in an enriched environment. To better understand how MR contributes to the mechanisms of neuroplasticity, in this first experiment, we also seek to compare cinematic measures of object manipulation (virtual vs. real). In the second MR intervention, an avatar will mimic the patient’s gestures and movements with real objects. This will give the patient an allocentric perspective of their movement. Moreover, these interventions will allow us to test the hypothesis that a MR motor training environment might have a beneficial effect on attention. Participants will be recruited from the pool of patients from the stroke outpatient program of NISA Hospital and clinical staff will contribute to data collection. The outcomes of those interventions will be compared with the outcomes of the conventional rehabilitation program (i.e. occupational therapy and physiotherapy without virtual or MR). We will not only assess motor function, but also attent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REPROGRAMMABLE GENERAL PURPOSE INSTRUMENT FOR DIGITAL SIGNAL PROCESSING IN SPACE' (SPACE-DSP).

assistant: **Innovation**

The emergence of reconfigurable FPGAs with space qualification opens up new opportunities in space missions. Until recently, implementing high-speed Digital Signal Processing (DSP) algorithms for space was only possible with anti-fusible technology devices. These devices are resistant to radiation but can be programmed only once. Up to now, this fact has determined the development of space instruments, as designs are optimized for a concrete functionality.The system proposed herein is a general purpose instrument which is reprogrammable in orbit and multi-experiment. It has a programming memory that is remotely configured via radio link with Earth, so the functionality of the instrument can be totally modified from Earth. The DSP algorithms of the FPGA can then be updated or corrected depending on the space mission’s requirements or clients’ interests. It offers a completely new business outlook: the instrument can either be sold to companies that want to optimise the resources of their satellite or be rented and exploited by different companies in a multi-experiment distribution or validation hardware.This document is to request a feasibility study according to phase 1 of the Common Conditions of Horizon 2020 and its dedicated Work Programme 2014-2015. In particular, it refers to SME-SPACE-1-2014/2015: SME instrument, and offers a transversal range of applicability within this topic. This feasibility study (phase 1 of SME instrument) will be guided by the Spanish company AD TELECOM and is expected to include other members and subcontracted members in a future phase 2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'PANcreatic CAncer Initial Detection via liquid biopsy' to be submitted under Horizon Europe.

assistant: **Abstract**

Pancreatic cancer (PDAC) is usually detected at late stages and most patients die within one year after diagnosis. In PANCAID we will therefore develop a blood test for early detection of PDAC. Despite tremendous technological advances in Liquid Biopsy Diagnostics (LBx), this goal is very ambitious because small tumors release only minute amounts of cells or cellular products (e.g., DNA, RNA, protein, metabolites) into the circulation. Thus, tests with a high sensitivity are required but increases in sensitivity are usually achieved on the expenses of reduced specificity which can lead to significant overdiagnosis leading to unnecessary stress for the individuals with a false-positive blood test and high costs for the health system. In PANCAID, we will therefore establish a blood test with high accuracy by analyzing large cohorts of patients with PDAC and its precursor lesions, individuals at risk to develop PDAC and appropriate age-matched control groups (healthy and non-cancer diseases frequent in the targeted population). Ambitious objectives of PANCAID include (1) establishment of a unique resource of blood samples of early PDAC and risk groups (WP1); (2) Establishment of a breakthrough blood test for early diagnosis of PDAC (WP2); (3) Identification of the best composite biomarker panel by integrating multimodal features in an AI-assisted computational analysis; (4) Analysis of the socio-economic impact of early PDAC diagnosis (WP4); and (5) Definition of the ethics parameters relevant to early PDAC detection (WP5). A robust multi-biomarker panel will be determined during the training period (year 1-3) and subsequently validated on bio-banked blood samples (year 4-5).  Depending on the outcome of this comprehensive analysis, PANCAID will provide the design of a fut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Refractive Index Observer' (RIO), addressing dissemination and exploitation.

assistant: **Impact**

Microscale chemical gradients are essential in life sciences, materials science, and chemical processes, yet existing measurement methods rely on fluorophores or dyes that inherently alter system properties and provide only indirect insights.With this PoC, we aim to revolutionize their quantification by further developing and ultimately commercializing RIO - the Refractive Index Observer - an add-on device for optical microscopes that enables label-free, high-resolution characterization of chemical gradients at the microscale.  The technology uses Fabry-Pérot interferometry to obtain time-resolved two-dimensional (2D) refractive index (RI) maps at the microscale and convert this information into chemical gradient mapping. With a resolution of at least 2x10-5 RI units, RIO is comparable to a benchtop refractometer for bulk samples but with the spatial resolution of a typical optical microscope and a 10-millisecond time resolution.  RIO is born out of the ERC CoG “ACTIVE_ADAPTIVE” as a tool to measure chemical gradients in active matter systems. We have already patented the technology, which is at TRL4. With this PoC we aim at taking RIO to TRL6/7 and lay the groundwork for its commercialization by: 1. Developing the current hardware to (i) push the time resolution to sub-millisecond while maintaining the highest RI resolution and (ii) create a palette of customized interferometric microfluidic chips to cover a broad range of application fields.2. Advancing the control system and software via a robust, professional and intuitive graphical user interface (GUI).3. Conducting a techno-economic assessment of the technology alongside a product-market fit evaluation.4. Carrying out user testing and fundraising for pre-commercialization. If successfully implemented, RIO has the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Modulation of tRNA pool and tRNA fragments in obesity and diabetes; focus on their role in macrophage activation and exosome-mediated crosstalk with pancreatic beta cells' (MATREX) under Horizon 2020.

assistant: **Objectives**

Obesity is a major public health concern and represents the strongest risk factor for type 2 diabetes (T2D) development. In T2D pathogenesis, inflammation contributes to multi-organ insulin resistance and pancreatic β-cell failure. Macrophages (Mφs) in adipose tissue and pancreatic islets play an important role in organ homeostasis, however their metabolic switch leads to chronic inflammation in obese individuals. The functional profile of obese Mφs reflects a high complexity, not explained by the classical model of pro-inflammatory activation. This suggests that unknown molecular modulators, higly sensitive to environmental changes, might control the activation of Mφs. Here I propose to investigate the role of transfer RNAs (tRNA) and tRNA fragmentation in in Mφ activation and diabetes pathogenesis. The ensemble of tRNAs in the cell is under strict regulation of nutrient availability and directly controls protein translation; also, tRNA fragmentation is controlled by stress factors and leads to the formation of tRNA fragments (tRFs), highly functional non-coding RNAs. I propose to study changes in tRNA pool and tRF signature in Mφs from adipose tissue and pancreatic islet using the db/db mouse model. I will analyse how protein translation is associated with tRNA pool, using ribosome profiling and computational methodologies. In addition, I will investigate the function of tRFs in the crosstalk between Mφs and β-cells via exosomes and their role in modulating β-cell function. I will use a Mφ-specific mouse model allowing the labeling of small RNAs in Mφs and the detection of the transferred molecules in β-cells. I will therefore combine high-throughput and in vivo innovative approaches to achieve the following aims: 1) Analyze the modulation of tRNA pool and translation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Islands as natural laboratories of global warming: discovering insects’ ability to survive thermal extremes'.

assistant: **Objectives**

Global warming will increase the frequency of extreme heat events, exemplified by this years European heatwave. These thermal extremes pose challenges to insects, who play an indispensable role in terrestrial ecosystems, and whose body temperatures rise with habitat temperatures. Given the alarming trend of global insect declines, it is essential to understand their adaptability in the face of rising temperatures. IGNITE aims to answer one of the most urgent questions in ecology todayWill insects be able to survive the upcoming heat stress?To answer this question, we will test insects resilience to thermal extremes using an interdisciplinary approach that integrates insect physiological and behavioral responses with relevant micro- and macro-climates. Using state-of-the-art 3D thermal imaging of the habitat, we will determine how microclimatic heterogeneity combined with insect behavioral thermoregulation governs insect survival to extreme heat. While such microclimatic insights are pivotal, predicting long-term changes requires a macroclimatic perspective. Thus, we will develop a high-resolution climatic model of surface temperatures to forecast heatwave frequency and intensity on Mediterranean islands. We will test insects thermal plasticity potential with novel reciprocal transplant experiments in both the field and laboratory. We will use ants as model insects, due to their global distribution and ecological importance. Under temperature extremes projected by the macroclimatic model, we will determine ant thermal plasticity and its ramifications on ecosystem functions such as seed dispersal, plant productivity, and biodiversity.IGNITE integrates findings from climatology, behavioral ecology, and ecophysiology to understand insect resilience to temperature increases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Composition and Sources of Atmospheric Organic Aerosol and their Negative Health Effects' (COrANE).

assistant: **Innovation**

Atmospheric aerosol particles are key components of the earth’s climate system and are one of the major air pollution components. In both areas large uncertainties are associated with aerosol effects. The chemical composition is a major parameter determining the effects of aerosols on the climate and their health effects. A major but poorly defined fraction of the aerosol is organic material formed within the atmosphere (so-called Secondary Organic Aerosol, SOA). Only a comprehensive chemical analysis of SOA simulated in laboratory experiments can rigorously identify and quantify SOA sources. However, only a small minority of the SOA mass can be characterized on a molecular level due to fundamental limitations of conventional analytical-chemical techniques. Thus, there is a large uncertainty how accurate current laboratory experiments mimic atmospheric SOA. This uncertainly critically limits our ability to assess the role of aerosols in the climate system, to determine their toxicity and also constrains further improvements of legal limits for ambient particle concentrations.The main SOA sources will be identified in this project in unprecedented detail by developing novel analytical techniques to characterize SOA comprehensively (mainly ultra-high resolution mass spectrometry). Generation of SOA in improved laboratory experiments and comparison with field samples will help to overcome the long-standing uncertainties described above.Particle properties responsible for health effects are poorly understood, but oxidizing particle components are likely important in understanding particle-cell interactions. Compound classes in SOA will be quantified, which are potentially damaging biological tissue such as peroxides and radicals, using the strongly improved laboratory condi