RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Novel Matrix Stiffness-regulated Genes in Lymphangiogenesis and Angiogenesis'.

assistant: **Objectives**

Endothelial cells (ECs) recognize and respond to mechanical forces through their cell-cell and cell-matrix adhesions and translate physical stimuli into biological responses in a process called mechanotransduction. The composition and mechanical properties of the extracellular matrix (ECM) differ across the vascular tree, in its surrounding tissues and in development and diseases, such as edema formation. I have recently shown for the first time that ECM stiffness fundamentally controls lymphangiogenesis. I hypothesize that changes in ECM stiffness are a key regulatory mechanism of angiogenic processes in development and disease. A comprehensive analysis of novel ECM stiffness-regulated genes is pivotal to understand these processes integrally. In a preliminary study, I have performed differential RNA sequencing of blood (B) and lymphatic (L) ECs cultured on soft and stiff matrices. 3200 genes were regulated similarly in BECs and LECs in response to changes in matrix stiffness. Interestingly, the same number of genes was differently regulated. In the next two years, I will study the role of selected genes in lymphangiogenesis and angiogenesis in vitro and in transgenic mouse models with state-of-the-art microscope and live imaging techniques. First, I will analyze an actin-regulating protein family that is significantly regulated by matrix stiffness in both, BEC and LECs, suggesting a more general role in lymphangiogenesis and angiogenesis by regulating cytoskeletal dynamics. Second, I will study a molecule, which is involved in intracellular cGMP signaling and is predominantly regulated in LECs, suggesting a more specific role in lymphangiogenesis. Last, I will generate an in vitro fluorescent stiffness sensor to live-visualize changes in stiffness inside the EC. Ultim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Using musculo-postural biofeedback in virtual reality for pain management in musicians' in the context of a Horizon 2020 call.

assistant: **Objectives**

Performing a musical instrument requires the coordination of repetitive motor patterns under sustained abnormal and non-ergonomic static postures. As a result, it exhibits one of the highest prevalence rates in work-related musculoskeletal disorders. The aim of project TONE is to develop and test with empirical research, an innovative tool that will assist musicians in developing preventive and pain-management strategies against task-specific musculoskeletal pain. This tool will comprise of a virtual mirror biofeedback system that will display musculo-postural parameters on a virtual character simulating in real time the movement of musicians during instrument performance. Corrective feedback will also be displayed in real time when abnormal musculo-postural activities are detected. In addition, a complementary VR game will be designed to be used with the biofeedback system to evaluate whether attentional distraction during instrument playing can be an effective intervention against pain. The effectiveness of the virtual mirror biofeedback tool and the VR game in preventing and/or reducing pain symptoms from abnormal musculo-skeletal activities executed during non-ergonomic postural activities (such as playing a musical instrument), will be assessed in experimental studies with healthy musicians, as well as with musicians suffering from acute or chronic pain.  Thus, TONE will contribute new research findings that will help to better understand how pain in work-related musculoskeletal disorders manifests and how it can be treated. As work-related musculoskeletal disorders exert great cost on economy -- equal to 3.3% of EU GDP – it is rather imperative to develop and validate effective non-pharmacological treatment interventions. Project TONE aspires to provide a crucial
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Data and METAdata for advanced digitalization of manuFACTURING industrial lines' (MetaFacturing) targeting Horizon Europe.

assistant: **Abstract**

MetaFacturing focuses on a digitized toolchain for metal part production which will lead to a more resilient production process with respect to the raw materials used (e.g., recycled materials), reduces operator effort and cost, and reduces scrap due to out-of-specification parts. The vision is to create a widely-applicable Digital Twin based process setup and control framework, fulfilling the requirements of industrial scale parts manufacturers (with a specific focus on metal parts) whose central hurdle is the effective use of available part and process data to improve the time-to-market and product quality. This framework will strongly leverage on a range of state-of-the-art technologies in the field of model-based data fusion, efficient process simulation, and data standardisation, and continuous Life Cycle Assessment in order to efficiently develop solutions which are tailored for deployment in industry. MetaFacturing project brings together 6 market leaders (FRONIUS, NEMAK, FILL, VITRONIC, BENTELER and LTH) which will closely cooperate in order to reach a new level of leadership in sustainable manufacturing while maintaining their respective market dominance. The envisaged approach will exploit all available data in the process, starting from material data, in-process measurements, end-of-line quality control and sampling-based product validation. The Digital Twin based approach will enable the holistic consideration of this data in order to provide automatic feedback for the process control, as well as providing novel (meta-)data on the materials used which will be valuable to train the engineers working with these materials.


**Keywords:** Digital Twin, data analytics, Artificial Intelligence, sensor fusion, material characterization, scrap reduction, Life Cycle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dwarf galaxies in context: connecting their physical and dynamical properties with the cosmic web'.

assistant: **Concept**

The 'Λ + cold dark matter' (ΛCDM) model is the cornerstone of modern cosmology. It successfully predicts the emergence of the cosmic web; a vast, filamentary network comprising all matter in the Universe that drives the evolution of galaxies. However, recent JWST observations of low-mass dwarf galaxies from the early Universe challenge key predictions of galaxy formation models within the ΛCDM framework. This could signal a fundamental issue with ΛCDM or reflect that dwarf galaxies are currently poorly understood. Crucially, existing models overlook the impact of the cosmic web on dwarf galaxies, which are often studied in isolation despite their sensitivity to their environment. This risks misinterpreting observations and obstructing efforts to test ΛCDM rigorously. The primary objective of this project is to develop novel models encapsulating the impact of the cosmic web on the internal physical and dynamical properties of dwarf galaxies. With the rapid influx of new dwarf galaxy observations from flagship observatories, and the promise of orders of magnitude more data from upcoming next-generation facilities, developing these models is not just timely but critical. They will unlock the full potential of this transformative data and offer unparalleled insights into the fundamental processes shaping galaxies.


**Keywords:** Zoom-in hydrodynamic simulations of dwarf galaxies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project '3rd forum of european neuroscience (FENS FORUM 2002)'.

assistant: **Objectives**

This is the largest European conference on Neuroscience, organised by the French Society des Neurosciences on behalf of the Federation of the European Neuroscience Societies. From July 13 to 17, 2002, it will discuss and present cutting-edge developments in Neuroscience. With 8 plenary lectures by leaders of the field, 51 thematic symposia, and 4500 poster presentations, it will cover a broad range of topics from basic science to clinical applications such as neurodegenerative and psychiatric disorders. 6000 delegates are expected, and a considerable effort will be made to attract young scientists from all over Europe, particularly from Eastern European countries. The objective of this Forum is not only to promote scientific progress, but also to trigger collaborations between European scientists and contribute to the development of collaborative research and the establishment of Neuroscience networks across Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cosmic Ray Tomograph for Identification of Hazardous and Illegal Goods hidden in Trucks and Sea Containers' in the context of a Horizon 2020 call.

assistant: **Objectives**

Everyday our customs workers need to tackle counterfeit goods and piracy to protect the health and safety of our citizens, yet it is estimated that only a small fraction of cargo is inspected and even smaller fraction of illegal goods are detected. Today, the most widely used technology for scanning vehicles, ranging from vans and trucks to railcars, is gamma-ray and X-ray radiography. But new technologies are required for overcoming current technological shortcomings like inability to detect the materials, usage of radioactive and harmful source, low throughput to name some.Cosmic-ray tomography (CRT) is considered as beyond the state-of-the-art technology in cargo screening. Cosmic-ray muons are highly penetrating, their average energy is about 10,000 times the energy of a typical X-ray and they are practically non-absorbable. They are suitable to identify materials hidden inside of shielded material, too thick or deep for other imaging methods. The CRT is completely passive, exploiting naturally occurring secondary cosmic radiation. Contrary to conventional X-ray or gamma-based imaging techniques it allows to distinguish between different materials and localizes it inside the cargo or vehicle by providing visualised 3D image.We will bridge the major security gap for fast and safe inspection of large number of cargos by developing the Multi-Functional Passive Detection System. The detection capability is based on using high accuracy sensors for particle tracking in combination with beyond state-of-the art tomographic reconstruction and material classification algorithms.The main objective of SilentBorder is to develop and validate a new high-technology CRT scanner for border guard, customs and LEAs that enables safe and fast screening, detection and identification of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bioengineering the neural stem cell niche to identify regulators of fate determination' under Seventh Framework.

assistant: **Concept**

Although neural stem cells (NSC) have been isolated successfully and characterized relatively extensively, little is known about the role of their natural microenvironment, the so-called niche, in influencing their behavior. The role of distinct niche signals and their spatial orientation in regulating the choice between quiescence, self-renewal or differentiation is poorly understood, due in part to a lack of suitable in vitro model systems. The main goal of the proposed project is to investigate how extracellular signals affect symmetric/asymmetric cell division of single neural stem cells. This will be achieved by generating artificial microenvironments recapitulating key biochemical and structural characteristics of stem cell niches, that allow to expose NSCs to a variety of protein signals in a spatially-controlled fashion, and allow high-throughput tracking of single stem cells by time-lapse microscopy and retrospective fate analysis. Understanding the basic mechanisms that regulate the balance between self-renewal and differentiation of tissue-resident stem cells will open up new opportunities for their clinical application.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mechanisms that prevent aneuploidy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The mechanisms that safeguard cells against aneuploidy are of great interest as aneuploidy contributes to tumorigenesis. To gain insight into these mechanisms, I studied the behavior of cells entering mitosis with damaged chromosomes. I used the endonuclease I-CreI to generate acentric chromosomes in Drosophila larvae. While I-CreI expression produces acentric chromosomes in the majority of dividing cells, remarkably, it has no effect on adult survival. Live studies reveal that acentric chromatids segregate efficiently to opposite poles. The acentric chromatid poleward movement is mediated through DNA tethers that connect the acentric fragment to its centric partner. Three highly conserved kinases, BubR1, Aurora B and Polo localize on the tether and facilitates the accurate segregation of acentric chromatids by maintaining the integrity of the tether.Chromosome segregation must be tightly coordinated with cell division to ensure that cells do not divide before the chromosomes have cleared the cleavage plane. However, the mechanism that permits this coordination is unknown. To identify this mechanism, I studied the behavior of cells going through mitosis with abnormally long chromatids. I took advantage of my previous discovery that acentric chromosomes remain attached to their centric partners by a DNA tether. This tether effectively increases the size of sister chromatids during anaphase. Remarkably, the cell adapts to the size of the long chromatids by increasing in length. Cell elongation enables long chromatids to clear the cleavage plane in time for cell division to occur properly. This novel cell elongation mechanism involves myosin activity.I have discovered two mechanisms that prevent aneuploidy: the tether-based acentric segregation and the elongation of the ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Cost-efficient and safe cellulosic food pad'.

assistant: **Concept**

Food pad absorbers used in the fresh food packaging to soak up the exuded liquid and keep food fresh are made of synthetic superabsorbent polymers (SAPs) – i.e. 90% of the market share - due to their superior price-efficiency balance. Nevertheless, proven toxicity and carcinogenic effects related with their use have raised growing health concerns. To put these dangerous practices aside, the need of economical biodegradable and non-toxic pads to compete with the synthetic ones are on the rise.CELLCOMB a Swedish company specialized in cellulose-based laminated products, has developed CELLSORB- a totally safe (i.e. non-toxic) closed food pad made from bioplastics and natural absorbent micro-cellulose material with the following superior features: 1) highly absorption capacity, similar with the performance of synthetic food pads, 2) It is fully compostable and 100% renewable, and 3) Competitive pricing over synthetic made food pads.Through CELLSORB, we will position us as a competitive company in the framework of alternative natural absorbent materials for fresh food packaging. We expect to reach around 20% share of the European food pad industry by 2026. Our highly absorbent micro cellulose material will not only be constrained to the food pads but in a long term it will expand its application to other known verticals like diapers, feminine hygiene and wound care products, highly demanded. The impact of CELLSORB in our whole business is expected to allow us growing 5-fold, and reaching an EBITDA of €12.1 million by 2026.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Improving the lives of Parkinson’s Disease patients while reducing side-effects through tailored deep brain stimulation' to be submitted under Seventh Framework.

assistant: **Abstract**

The IMPACT project is about improving the lives of brain diseased patients through a novel approach that leaps beyond currently available Deep Brain Stimulation (DBS) devices and procedures. The initial project focus is on Parkinson’s Disease (PD), but further brain-disease indications will be included in the later phase of the project. The personalized approach that IMPACT brings is essential in delivering full therapeutic benefits to DBS patients while preventing the stimulation-induced side-effects that occur with today's DBS implants.PD is well known for its characteristic symptoms: shaking, rigidity, slowness of movement and postural instability. Millions are suffering from PD including famous people like Michael J. Fox. Drugs are used as first treatment, but as the disease progresses they become ineffective and increasingly higher doses are needed. This leads to many side-effects, while symptoms still persist.DBS is a ‘pacemaker for the brain’, analogous to the function of pacemakers for the heart: mild electrical stimuli are delivered to brain tissue to suppress unwanted activity and restore desired neuronal functions. When stimulation is optimal, the impact of DBS is spectacular: shaking and rigidity are strongly improved, and medication doses may be lowered significantly.Despite its successes, DBS is still in its infancy. Programming for optimal therapy is complicated since physicians lack the appropriate tools to support them. Around 15 – 30% of DBS patients suffer from stimulation-induced side-effects resulting from stimulation leaking outside intended target regions. IMPACT addresses these barriers to adoption exploiting the directivity provided by next generation high-resolution implants.IMPACT delivers a physician tool for tuning the high-resolution implan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CIliates as NAtural Reservoir of potentially PATHOgenic BACTERia: an ecological, functional and evolutionary genomic investigation' (2007-2013).

assistant: **Concept**

In the last years, Protists (Protozoa) gained a significant attention from the scientific community because of their role as Trojan horses respect to opportunistic pathogens of humans and animals. Although this role is nowadays well established and accepted for some Protists like Acanthamoeba, little is known for other groups of possible hosts. Recently, members of the coordinating unit of Pisa got evidences that many of the natural occurring bacterial symbionts of ciliates have a strong phylogenetic affiliation to human and animal (especially fish) pathogens like Rickettsia (Vannini et al., 2005; Ferrantini et al., 2009; Ferrantini et al., in prep) and Francisella (Schrallhammer et al., in prep.). These observations raised the question whether ciliates may also represent natural reservoirs for potentially pathogenic bacteria especially in tropical regions where the environmental conditions favor microbial growth and fast evolution. Furthermore tropical countries are predicted as the Hot Spot for emerging infectious diseases and zoonosis due to hygienic standards lower than in Western countries and the living together of humans with their farmed animals. Aim of the present project is to set up an international research network that, starting from the collection of novel isolates especially from tropical regions, performs a complete ecological, functional and evolutionary genomic investigation on symbiotic bacteria retrieved from ciliates that shows phylogenetic affinities to pathogenic ones. Units from the proposed network posses expertise that ranges from the traditional morphological investigation to advanced ultrastructure, ecology, functional biology, molecular phylogeny, comparative genomics and postgenomics. Aim of the research network will be to coordinate the re