RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding the nanoscale synaptome architecture of the brain' (SYNarch).

assistant: **Concept**

Synapses play an essential role in all behaviours and damage to synapse proteins results in over a 130 brain disorders. The host Grant lab has developed methods for brain-wide mapping of protein composition at single-synapse resolution, uncovering unexpected diversity. The different synapse types show unique spatiotemporal distributions in the brain across the lifespan, which are altered in genetic models of autism and schizophrenia. Synapse proteins are assembled into multiprotein complexes and supercomplexes, but little is known about their composition and spatial organisation within individual synapses, particularly in the intact brain. In SYNarch I aim to understand this subsynaptic protein architecture, its contribution to the spatiotemporal organisation of synapse diversity, and alteration in disease. The work plan will deliver a depth of skill acquisition integrated across a range of cutting-edge biochemical, molecular imaging, ultrastructural and computational technologies. In WP1 I will optimise use of Förster resonance energy transfer (FRET) to probe the sub-10 nm spatial relationship and number of endogenously labelled PSD95 complexes within individual synapses, backed up by complementary super-resolution microscopy techniques (STORM, TIRF) and microfluidics analysis. In WP2, FRET will be integrated with synaptome mapping technology to deliver an atlas of nanoscale information on a brain-wide scale – the PSD nanoscale synaptome architecture (PNSA) of the mouse brain. In WP3 I will uncover how the PNSA is impacted in the Dlg2 schizophrenia mouse model. SYNarch will help to provide new molecular insight into brain function and dysfunction on an unprecedented scale.


**Keywords:** Synapse diversity, Synaptome, Postsynaptic density (PSD), Förster resonance energ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DEFect NETwork materials science and engineering', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Porous coordination network materials, also known as Metal-organic Frameworks (MOFs), are at the cutting edge of molecular materials science. DEFNET, “DEFect NETwork materials science and engineering”, is the first European Training Network (ETN) at the intersection of chemistry, physics and engineering aimed at structural and functional complexity of MOFs. It provides a unique interdisciplinary training platform for early stage researchers and combines the expertise of the academic and the non-academic sector for fundamental development and industrial application and technology transfer aspects. The research and the training program in materials synthesis, characterization, computational modelling and application is accomplished in a coordinated effort involving 8 academic and 8 industrial partners from 6 European countries. DEFNET will particularly investigate defects, disorder and correlated phenomena in MOFs and related materials. The understanding and the intentional modification of defect structures of porous coordination networks is essential for advanced controlling their properties in catalysis, gas capture and separation beyond existing materials limitations. Benchmarking will be done against selected zeolite materials, which are very well established for large scale industrial applications. It is anticipated that superior functionalities of defect engineered MOFs will be identified which cannot be achieved by employing other porous materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MELWICH WINDFARM 1 5MW WIND TURBINES' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The proposal is the manufacturing, installation and operation of five 1.5MW wind turbines (Nordtank). The turbines are based on the newly developed prototype, presently being tested in Denmark. The wind farm shall be located on a rough terrain in Scotland near the Atlantic coast. The annual wind speed at the site is 8.5m/s at hub height (60m). Measurements similar to the ones of the prototype to compare loads in different climatic conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Platform for Operations and Maintenance Management of Power Smart Grids based on advanced algorithms and artificial intelligence' (Algo-Grid).

assistant: **Concept**

The deployment of smart grids is crucial for achieving a more secure and sustainable energy future. In fact, beside addressing current concerns with existing electricity systems (e.g., ageing infrastructure and increasing peak demand), smart grids are fundamental for the diffusion of low-carbon technologies, including electric vehicles and variable Renewable Energy Sources. Significant revenue losses are still experienced in the existing power networks, but the convergent advances in computing and ICT, the accelerating deployment of renewable generation and storage technologies offer new opportunities for advanced Operations and Maintenance Management (O&MM) to ensure more reliable, efficient and resilient power electric grids meeting environmental performance goals. Then, ARAMIS proposes the present Algo-Grid project, for deploying a platform for O&MM of power grids. ARAMIS was founded in 2012 in Milan, Italy, by a group of (PhD) researchers of the Politecnico di Milano. The mission of ARAMIS is to develop and deploy methods, models, techniques and algorithms for the analysis and optimization of industrial components and systems, particularly, in terms of safety, reliability, maintenance, resilience, asset management, etc.Algo-Grid is based on specifically designed Prognostics and Health Management (PHM) solutions, time series prediction algorithms, energy flow simulators and optimization algorithms, which can provide real-time optimal configurations of smart grids (generation, transmission and distribution), predict and assess infrastructure health condition, incorporate policy-based rule logic.A preliminary estimation yields a Return On Investement (ROI) of 4,63M€ for the years 2020-2024. Cumulative profits in 2024 deriving from direct sales in EU28 and target market
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Plant-made GREEn Kit' (Pgreek).

assistant: **Innovation**

The proposed project aims to put the basis for the commercialization of a new kit for the definitive diagnosis of Sjogren’s Syndrome, an autoimmune disease with an high incidence in the population (up to 4%) and characterised by serious complications. The product relies on proteinaceous nanomaterials produced in plants, namely virus-based particles, characterised by superior performance in ELISA tests compared to actual diagnostic systems. One of the main advantages of the proposed product compared to existing ones is that it gets rid of the need of a biopsy procedure for disease diagnosis while increasing the specificity of diagnostic outcomes.The project aims to explore the potential of this novel and high-performing product in the EU and US markets, given that the patent has been already filed and that the actual company asset is already capable of supporting the forecast needs of the kit in the EU market. Furthermore, the π project will help the company in envisaging several aspects before the product commercialization, spamming from a clear definition of the normative procedure for its commercialization in different countries to the set-up of a business strategy for its distribution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Formation of tissue boundaries during zebrafish embryogenesis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

During animal development, boundaries need to be reliably established between cell types to guarantee the physical and functional integrity of tissues. This process requires delicate orchestration of cell proliferation, differentiation and migration, and defects in tissue boundary formation are often linked with abnormal cell behaviours in diseases. Genetic programs involved in cell signalling and cell sorting across tissue boundaries have been previously identified, yet we still lack a systematic understanding of the mechanisms underlying boundary formation, because it has been challenging to analyse the coordination of gene expression, cell lineages and cell movement in space and time. In this study, I will probe the in vivo mechanisms of tissue boundary formation using the zebrafish embryonic shield as a model system. The embryonic shield in zebrafish embryos is an evolutionarily conserved “organizer” structure that is critical for setting up the overall body plan of the embryos. The shield region contains overlapping progenitor cells that give rise to various tissue structures whose boundaries form and sharpen during gastrulation. However, the formation of shield progenitor cells into compartmentalized tissues has been a process that is poorly characterized, and the molecular and biophysical mechanisms that coordinate cell differentiation and morphogenesis to establish tissue boundaries remain elusive. I will utilize multi-disciplinary approaches that combine live imaging, spatial transcriptomics and genetic manipulation to determine how shield cells differentiate and generate tissue boundaries. I anticipate identifying cellular and genetic mechanisms controlling boundary formation, and provide a comprehensive and dynamic atlas detailing cell lineages, cell movement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'in Search Of Certainty - Interactive Event To inspire Young people' (SOCIETY).

assistant: **Innovation**

SOCIETY (in Search Of Certainty – Interactive Event To inspire Young People) European Researchers' Night  events will take place in 5 cities (Bologna, Forlì, Cesena, Ravenna and Rimini). SOCIETY  aims to present research as the best tool to investigate solutions, ideas and innovations to sort out the Societal Challenges that human beings face. In order to achieve its objectives, SOCIETY will rely on interactivity and engagement at large:  the project will specifically aim to produce a Night co-design approach, in which researchers together with society will conceive the event programme.SOCIETY project will be extended to two editions of ERN, in 2016 and in 2017, with a project duration of 18 months. The line-up of  each Night event will be structured as a subway map, with different lines and stops. Each line will represent an interdisciplinary pathway in some specific big topic for which researchers are trying to find some possible solutions and ideas. The two events will maintain the same overall theme, but a relevant evolution in public collaboration, which will support the design of the programme event, will be envisaged. The co-design of ERN events will act as a concrete lab experience for European researchers in structuring a bottom-up public communication event. The public will have a key role in the project, not only as target, and will be engaged to collaborate in the outline of an event tailored for societal interests.Researchers and research will benefit from this approach as a whole in terms of public support and acknowledgement of the importance of research work for society.SOCIETY Night events will be designed in order to attract different kinds of publics . However, secondary school students, who are about to make their choice in terms of career, will be a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Preservation and Efficacy of Music and Singing in Ageing, Aphasia, and Alzheimer’s Disease' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

For the human brain, music is a highly complex and versatile stimulus that is closely linked to speech, executive-motor, emotion, and memory networks. In severe ageing-related neurological disorders, such as post-stroke aphasia and Alzheimer’s disease (AD) dementia, music and singing may provide a valuable alternative route to verbal and emotional expression and to memory and self-awareness. However, the neural processes underlying this are still poorly understood. Moreover, although there is increasing evidence for the efficacy of musical activities in supporting normal neurocognitive ageing and enhancing neurological recovery, the focus has been on individual-level musical activities, overlooking the enormous social potential of music.PREMUS will combine modern behavioural and neuroimaging methods in the unique context of cross-sectional and cohort studies and clinical trials to achieve both fundamental and applied research goals. The fundamental goal of PREMUS is to determine the neural basis of singing, music-evoked emotions and memories, and explicit and implicit musical learning (i) across normal ageing, (ii) in aphasia, and (iii) in different stages of AD. The applied goal of PREMUS is to uncover the rehabilitative potential of social musical activities by (iv) exploring the long-term efficacy of choir singing on neurocognitive, emotional, and social functioning in normal ageing and mild cognitive impairment and (v) determining the rehabilitative efficacy of a novel intervention that utilizes adapted choir singing, melodic intonation therapy, and computer-based singing training on verbal, cognitive, emotional, and social functioning in aphasia, together with uncovering the structural and functional neuroplasticity changes underlying the effects of the singing int
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Cloud Based Software Solution for Next Generation Diagnostics in Infectious Diseases'.

assistant: **Objectives**

Infection is a leading cause of morbidity worldwide and incurs huge economic costs for both patient diagnosis and hospitalisation. Traditional wet-lab culture techniques often do not recognise particular bacterial strains such as the recently identified Campylobacter ureolyticus nor do they incorporate the resulting host response. In silico molecular detection methods flag such biomarkers and can facilitate rapid, efficient and accurate diagnosis. Major challenges in the widespread adoption of such techniques exist due to inter alia their complex computational characteristics, the need for software tools that are usable for both researchers and clinicians and the need for software solutions that are secure and auditable, providing full traceability and provenance of data. Therefore, the principal Scientific & Technological objective is to develop in silico techniques that can support rapid molecular diagnosis of infection and to embed these techniques in an efficient, usable, auditable and secure end to end diagnostic process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'INOvative Energy MANagement System for Cargo SHIP' in the context of a Seventh Framework call.

assistant: **Objectives**

The global optimization of energy systems aboard future and currently operating cargos is crucial to reduce greenhouse gas emission in a substantial and cost effective way. It is also of major economic interest in the merchant marine sector.A holistic approach considering the overall production and management of energy aboard ships (including propulsion systems and energy output optimization) is the most promising approach to accelerate the adoption of low emission-higher energy efficiency cargo ships.Taking this consideration into account and based on the array of innovative and renewable sources of energy, the INOMANS²HIP concept aims at proposing a break-through energy management system aboard ships based on a preferred DC network integrating all potential sources of energy. A Life-Cycle Analysis study will be performed. The proposed energy management system will gather data in real time and will be able to anticipate and optimize energy needs for each operational configuration of the ship considering risk levels while systematically favouring less polluting and cost effective sources of energy. The INOMANS²HIP project will therefore contribute to reducing green house gas (GHG) emissions and pollution as a whole (SOx, NOx, Noise). It will foster European competitiveness by providing an innovative global advantage to both European equipment manufacturers and shipyards.The INOMANS²HIP European consortium represents a well balanced combination of European industrial partners, institutions and organisations. It comprises world-class industrial leaders in their fields of activity, leading research organisations and institutions, experts of the world maritime sector and specialists of project management. This unique mix of expertise and knowledge will allow INOMANS²HIP to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Popularitas : pursuit of consensus and populism in ancient Rome' (POPULARITAS).

assistant: **Concept**

The Popularitas project aims to provide a comprehensive study of the precedents of populism in ancient Rome. The Latin adjective popularis had a passive meaning (the man who enjoys the favour of the people), but also an active one (the man who seeks the favour of the people). Sometimes this active meaning was employed in connection with ambitious outsiders, wannabe “charismatic” leaders, who took a perspective hostile to the senatorial elite, claimed to have a direct connection with the people, and exploited this connection in order to bypass the institutions, to subvert the constitutional rules, and to gain power. The object of the project is precisely this political attitude, where the legitimate seeking of consensus turned into populism: what are the similarities and differences between ancient and contemporary populism? how far the allegations against ancient populists were well-founded? did populistic attitudes have ideological implications? to what extent populistic methods were effective? what was the people’s feedback? The main output of the project will be the publication of a monograph on the populism in ancient Rome and of three scientific papers; a two-days international conference on “ancient and modern populisms”, open to classicists, modern historians, and political scientists; a course of lectures on the ancient populism in the secondary schools; the creation of an internet site, intended both for scientific and educational use.The Popularitas project will historicize for the first time a much-discussed political phenomenon of our time and highlight similarities (and differences) with the ancient political practice. It will provide the tools for a diachronic assessment of modern populism, opening new research prospects. Its ambition is not only to be use