RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Shot-noise Limited Optical Waveguide MOdule' (2014-2020).

assistant: **Innovation**

Fibre lasers have become highly prevalent due to their cost, stability and practicality. However, they are inherently noisy and this is a severe limitation when using them for microscopy, spectroscopy or generate quantum states of light. We propose to develop a “plug-and-play” module that can be retrofitted to fibre lasers that are already deployed in the field, which reduces the optical noise at the laser output down to a fundamental limit of classical physics. This proof of concept grant will enable us to advance the commercial readiness of this noise suppression module, commission market research to identify potential customers, engineer a robust demonstrator for deployment outside the optics laboratory and foster relationships with end users willing to take part in trials. This project will bridge the gap between academic research and commercial exploitation of filter modules that allow lasers to operate at the fundamental shot noise limit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Consequences of global biodiversity loss and climate change for decomposer communities and implications for forest carbon fluxes' in the context of a Horizon Europe call.

assistant: **Objectives**

Forests play a central role for global carbon cycling and biodiversity. Yet, the unabated continuation of climate change and increasing anthropogenic pressure on forest resources are altering forest ecosystems by modifying species composition and ecosystem processes. Increasing temperatures are likely to increase decomposition rates and thus carbon emissions, while the opposite effect may be expected from loss of decomposer biodiversity as land-use intensity increases. However, it remains unknown how climate change and land use interactively shape decomposer communities, decomposition rates and carbon fluxes. This limits the ability to model the future of the global forest carbon sink as well as of forest policy and management to counteract undesired developments. Here, I will investigate the joint effects of climate change and land use on decomposer communities and carbon fluxes from wood decomposition at the global scale, as well as the underlying processes and mechanisms. Making use of an operating network of 60 research sites on six continents, I will study how biodiversity-decomposition relationships and effects of land use change along global climate gradients. Empirical results will be used to model carbon fluxes from wood decomposition at the global scale and to generate projections of carbon fluxes under different scenarios of forest use and climate change. Extensive experiments will be conducted both in the field and in walk-in climate chambers to identify which facet of biodiversity drives wood decomposition and to unravel the mechanisms behind the climate-dependency of biodiversity-decomposition relationships. The BIOCOMP project will bring about a new level of understanding of how biodiversity and carbon cycling in forest ecosystems worldwide will change as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Eu governance by self co-ordination? towards a collective gouvernement économique"."' under Fifth Framework.

assistant: **Concept**

The project consortium analyses the dynamics of the new and/or amended legal provisions of the employment chapter and the pact for stability and growth as independent variable. Its major puzzle is to find out if and how institutional and intermediary actors on the national and EU level use these provisions, by which the creation, evolution and - possibly - the trans-formation of new modes of governance (the depending variable) are identified early in the experimental phase. Three sets of expectations concerning the modes of governance are tested within the two policy fields in view of a process of vertical and horizontal fusion towards a 'gouvernement economique' as governance of collective self co-ordination. Using qualitative as well as quantitative methods the project will study the patterns for interaction, deliberation, problem solving and decision-making by institutional and intermediary actors and public discourses. Special importance will be laid on the dissemination and public discussion of the results and their repercussions for political and societal actors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In-Line Service For Internal Inspection Of Unpiggable Buried Oil Pipelines Using Long Range Ultrasound Guided Waves In Fifty Metre Segments' (PIGWAVES).

assistant: **Innovation**

This proposal will aim to develop the enabling technology that will enable existing pipe crawling robots (pigs) to provide internal inspection of pipe walls using long range ultrasound guided waves (LRUG) deployed in pipe segments of about fifty metre length.The aim is to perform total volume inspection far more rapidly, accurately and cheaply than is presently achieved with magnetic and ultrasonic pigs by developing a circumferential collar of LRUG sensors and novel time reversal focussing to produce a map of the circumferential and axial pipe corrosion and cracks. As LRUG sensors detect all significant corrosion in oil and gas pipelines within typically 50 metre of the sensors in a few milliseconds, long lengths of pipe can be scanned very rapidly with sample wave echo patterns obtained only every 50 metres thereby data storage requirements will be orders of magnitude less than present inspection methods. The speed of travel through the pipe could thus be faster than pigs that gather data with ultrasonic compression probes.To test the technology developed by the project, the LRUG collar will be deployed initially by a mechanism to pull the collar through a pipe full of water at different constant and also varying speeds.A prototype robot will be developed that is intrinsically safe for operation in explosive environments and that is lightweight (neutrally buoyant) to investigate how best to deploy the LRUG technology in a real pipeline with faster travel and cheaper robots.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Solution-processed toxic metal-free alloy colloidal quantum dots for self-powered near-infrared photodetector application' under Horizon Europe.

assistant: **Concept**

Self-powered near-infrared (NIR: 0.7–2.5 μm) deteSelf-powered near-infrared (NIR: 0.7–2.5 μm) detection technologies attract immense interest both from scientists and industry experts due to their vital applications in environmental monitoring, night vision, and imaging in remote locations. However, available conventional NIR photodetectors (PDs) are based on costly fabricated inorganic semiconductor materials or toxic heavy metal-containing quantum dots (QDs), which restrict their use in electronics and biomedical applications. Silver chalcogenide-based (Ag2E, E= S, Se, Te) QDs have recently joined as new promising toxic heavy metal-free materials for NIR detection, making them appealing from health and environmental safety perspectives. Nevertheless, the development of Ag2E-based NIR PDs is in its initial stage and far behind the commercially available devices due to the lack of protocols for device-relevant thin film fabrication with favourable device architecture.In this project, we propose a novel approach to solve this issue, which consists of two strategies: (i) chemical synthesis of small Ag2E and MAgE alloyed QDs followed by thin film preparation with favourable legend and thickness, (ii) PD architecture with proper electrode and electrode distance. To achieve this, the first strategy will develop synthesis protocols to control the size of Ag2E QDs and optimize their absorption and electronic properties by ligand exchange for NIR PDs application with different metal electrodes and electrode distances. In the next stage, the potential metal alloy will be introduced into Ag2E QDs by cation exchange, followed by studying the optical and electrical properties to optimize the synthesis and thin film quality for self-powered NIR PDs. In the last stage, the work will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Host determinants of susceptibility to HIV-1 infection'.

assistant: **Innovation**

The natural course of HIV-1 infection is widely variable with extremes of disease progression within 2 years or continuous asymptomatic infection for more than 15 years. Moreover, certain people are relatively resistant to HIV-1 infection despite high levels of sexual risk behaviour (high risk seronegatives, HRSN). In the majority of cases, the underlying mechanism responsible for the variable outcome of exposure to HIV-1 infection is not known. We hypothesize that host factors that either restrict or enable HIV-1 replication will be additional targets for therapeutic intervention. In the present study we will focus on the role of host factors in determining HIV-1 susceptibility using genome-wide single nucleotide polymorphism (SNP) analysis.Participants of the Amsterdam Cohort Studies (ACS) have accurately documented levels of risk behaviour, moment of seroconversion for HIV antibodies and detailed follow up information on virological, immunological and clinical parameters, treatment history and disease course. Initially, we will perform SNP analyses on HRSN and the relevant control group, low risk seropositives (LRSP). In addition, CD4+ T cells from several of our HRSN participants have shown reduced susceptibility to HIV-1 in vitro. As host factors responsible for this reduced in vitro susceptibility may also be relevant in vivo, we will test in vitro HIV-1 susceptibility of blood cells from family members of these HRSN and LRSP to extend SNP analysis to these family members to increase the power of our analysis. Altogether, this will provide a genome-wide analysis of host polymorphisms that could be relevant to HIV infection.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'TRENDSETTER setting trends for sustainable urban mobility'.

assistant: **Concept**

TRENDSETTER's objectives are to ameliorate urban air quality and noise levels, and congestion while supporting exceptional mobility and urban quality of life. It will help other cities se how they can curb unsustainable traffic growth by using advanced mobility management schemes combined with clean vehicle fleets.TRENDSETTER aims to promote the use of public transport and other alternatives to private cars but also show new ways to improve goods logistics and efficiency. The project will increase the acceptance for bio-fuels among citizens and encourage operators, politicians and social groups to use innovative, low-noise and low emission technology by practical day-to-day operation.TRENDSETTER will prove that cities can achieve Kyoto and EU goals, e.g. by reducing fossil C02 by 5% through a combination of measures. The results are intended as inputs to European policy making and to set trends for a sustainable transport future in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mathematicae Lingua Franca: Bridging the Linguistic Gap Between the Mathematician and the Machine' under Horizon Europe.

assistant: **Concept**

In the recent years, proof assistants have shown their astounding ability to tackle the complete formalisation of large pieces of mathematics, with the celebrated certifications of the Feit-Thompson theorem, of the Kepler conjecture, and more recently, the resolution of Scholze liquid tensor challenge. We believe that the time is ripe to demonstrate that they can tackle mathematics in the flexible and semi-formal way it is created and exchanged by the mathematicians. To that purpose, we aim to develop proof assistant technologies of an entirely new nature, including a formal language and a foundational approach to mathematical meaning, with the versatility necessary to represent the dynamic linguistic structures to be found in the daily practice of mathematics. The result will be a linguistic front-end that will allow mathematicians, and scientists in general, to express in proof assistants their proofs and computations the semi-formal way they think of them. Three research tracks stand out: the mathematical and linguistic foundations; formalisation of real-world vernacular mathematics into a high-level language of representation (Godement challenge); new techniques and software tools, based on natural language processing, to automate the formalisation process. The translation in the machine of semi-formal mathematics needs to go beyond the traditional view that reduces reasoning to logic, and requires to understand the dynamics of the discursive linguistic process which underlines mathematics. Building on advances of linguistics, mathematical logic, programming language semantics and machine learning, we will contribute significantly to the rise of a new generation of proof assistants, integrating at their heart a linguistic layer and automated guidance tools for mathe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and optimisation of processing technologies for the production of dustless grainy biomass granulated material' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The project aims at developing and optimising processing technologies for the production of dustless, grainy biomass granulated material and to test it with regard to its suitability for production. In this way, an economically efficient production of defined granulated material consisting of a mixture of organic and inorganic components is to be achieved, while at the same time ensuring that the value-giving contents of the individual components are not affected through processing with regard to their impact. The scientific and technical objective of the project is the development and optimisation of machine parts and their coating for economic processing of the mixtures. The development of the form-giving machine parts as well as tests regarding their coating will be in the centre of the trials. The developed form-giving machine parts and their coatings will subsequently be tested with regard to their process aptness. As known from other economic branches, a modified surface design of the pressing tools can reduce, for instance, the thermal stress on the material to be processed. Concurrently, the edge life of the coated tools can be increased tenfold. The results of these tests are supposed to enable companies to select as quickly and efficiently as possible both the suitable form of the tool inserts and their coating according to the mixtures to be processed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Targetting breast cancer motility by disrupting the pkc-erm signalling complex'.

assistant: **Concept**

Of the protein kinase C (PKC) family of protein kinases, several isoforms including PKCalfa have been implicated in promoting a cell migratory phenotype. In MCF - 7 breast cancer epithelial cells, the signal machinery that drives cell migration towards Beta1 integrin substrates is dependent upon PKCCalfa-catalysed recycling of the activated pool of beta1 integrin receptors. More recently, Dr Ng's group has shown, by fluorescence resonance energy transfer (FRET) measured by fluorescence lifetime imaging microscopy (FLIM) and biochemical analyses, that ezrin (an F-actin-binding protein) interacts with PKCalfa upon activation and is involved in mediating PKC-induced directional cell movement. Also, PKCalfa is the only kinase shown in vivo to be responsible for the phosphorylation and hence activation of ERM (ezrin, radixin, moesin) proteins. The FLIM/FRET imaging approach allows for the first time a precise" spatiotemporal resolution of biochemical processes in living cells and archived pathological tissues. This study is designed to further characterize the molecular determinants of the PKC-ezrin complex formation. The aim is to understand the mechanisms underpinning breast cancer cell invasion.Basic studies will be conducted in human metastatic breast cells, which are stimulated to migrate towards a chemotactic factor gradient in the Dunn direct-viewing chamber. The results of these studies will help us to construct and screen retrovirally encoded minigenes, which should disrupt PKCCalfa-ezrin complex formation in order to target carcinoma cells in an athymic nude murine model of metastasis."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A long-lasting non-migrating hydrogel for relieving chronic pain' under Horizon 2020.

assistant: **Concept**

Chronic Neuropathic Pain (NeP) is an enormous problem globally. Estimates predicate that 20% of adults suffer from pain world-wide and 10% are newly diagnosed with chronic pain annually1. According to the EuroPain Innovative Medicines Initiative (IMI)2, one in five adults in Europe suffers from chronic pain.  One type of Neuropathic Pain that is particularly detrimental to patients quality of life is Trigeminal Neuralgia (TN). The trigeminal nerve is responsible for facial sensory function, and trauma to this nerve can result in sudden, severe, stabbing and recurrent episodes of pain. Patients with TN experience a prolonged debilitating condition, where the pain is often described as one of the most painful conditions in medicine. TN is infamously called the “suicide disease” as there have been numerous suicide reports associated with the condition. Epidemiologists estimated the prevalence of chronic TN pain is also large at 7%3, which amounts to 36 million Europeans. Similarly, in the US, the American Association of Neurological Surgeons report that 150,000 people are diagnosed with TN every year with a prevalence of chronic TN impacting 1.7 % of population 4. Therefore in this  proposal, we describe the development of a long-lasting and drug-free treatment for chronic Trigeminal Neuralgia.


**Keywords:** Hydrogel,  Medical Devices,  Pain management
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Priorities for Road Safety Research in Europe' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In spite of all improvements in European road safety, almost 100 people are killed and about 40,000 get injured on European roads each day. The progress made so far is to a large extent based on intensive, publicly funded road safety research activities. While many “low-hanging fruits” in road safety have already been picked, a multitude of more specific research issues remains. With ICT opening up an enormous potential for new integrated safety applications, the research area of road safety is becoming broader and broader with the risk of diluting efforts.As a result of the political focus on the greening and electrification of road transport, the focus of European road transport research funding has moved away from safety topics increasing the need to identify those safety research topics which public money will be invested in most efficiently.Therefore, PROS is to establish a pan-European network to develop commonly agreed priorities in road safety research and overcome the current fragmentation in relevant stakeholder groups. This network will follow an integrated approach covering human, vehicle and infrastructure aspects and all phases from pre-ventive to post-crash safety.The PROS concept starts from the identification of future safety research needs based on a review of future societal scenarios as well as existing research activities, agendas and roadmaps. These research needs will be subject to a transparent prioritisation and roadmapping process with maximum involvement of key stakeholders. The outcomes will be widely disseminated together with identified success stories to all interested parties. Following an iterative optimisation, the whole process will be ready for the long-term continuation of activities in a pan-European multi-stakeholder network.Due to