RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Mapping the cosmic expansion history with Type Ia supernovae'.

assistant: **Objectives**

Observations of distant Type Ia supernovae indicate that the expansion of the universe is accelerating, driven by a mysterious cosmic component called dark energy. Since the discovery, a standard model of cosmology has been established, wherein ordinary matter only consists of 5% of the energy density, the rest being dark matter (~25%) and dark energy (~70%). Recent, precision measurements of the local expansion rate, the Hubble constant, are in disagreement with the value inferred from the early universe, presenting the strongest challenge to standard cosmology. In this proposal, I will, for the first time, use gravitationally lensed Type Ia supernovae to measure the Hubble constant. Strongly lensed Type Ia supernovae are powerful probes of cosmology since the delay time between their multiple images directly measures the Hubble constant. Wide-field transient surveys like the Zwicky Transient Facility are designed to find tens of such events and hence, it is extremely timely to use them as precision probes in cosmology.Moreover, I will use the Hubble diagram of unlensed Type Ia supernovae in the near infrared to understand the nature of dark energy. Supernova cosmology in the conventional optical wavelengths is limited by systematic uncertainties. Hence, the near infrared is an exciting wavelength regime to improve them as cosmological probes. Type Ia supernovae are more uniform in the near infrared than the optical and there is significantly less extinction from host galaxy dust. Additionally, I will quantify the constraints on dark energy from future experiment, e.g. the Large Synoptic Survey Telescope.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Increasing Cell Culture Productivity by control of programmed cell death (Apoptosis)' to be submitted under Fourth Framework.

assistant: **Abstract**

Recent advances in understanding of the apoptotic death (Apoptosis) response of cells and of the underlying mechanisms controlling survival, growth and cell proliferation will be applied to the development of cell lines and culture strategies for the quantitative improvement of cellular and biologic product productivity. Specifically, the intention will be to use metabolic engineering to alter advantageously the survival and proliferative capacity of cells in intensive cell culture environments via the expression of bc1-2 and other genes known to be involved in the regulation of apoptosis, as well as of cyclin E which is primarily involved in Gl to S progression. Simultaneous overexpression of anti-apoptotic gene and cell cycle gene may well have synergistic positive effects in averting apoptosis. The suppression of apoptotic response will be particularly important in cell growth and adaptation in nutrient limited conditions and protein-free medium and as an aid to the specific production of proteins such as chimeric antibodies of improved fidelity under controlled but intensive culture conditions. Also, it should be possible to enhance viral production by blocking the apoptotic response known to be induced on viral infection, thereby reducing the rate of cell death and prolonging and increasing viral replication. The resolution of the primary metabolic pathways associated with apoptosis and the influence of anti-apoptotic gene activity on cellular metabolic fluxes during intensified bioreaction processes are major undertaking of this project. A major additional objective of this project is to increase interactions and collaborations between European research laboratories on one hand and between these laboratories and industry on the other. It is anticipated that the ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design and Engineering of gene networks to respond to and correct alterations in signal transduction pathways.' under Sixth Framework.

assistant: **Concept**

Recent progress in constructing small artificial gene networks has allowed the engineering of predictable logical switches, or system behaviours, by harnessing feedback loops (Becskei, A. & Serrano, L. Nature 405, 590-3 (2000)). It should be possible to apply our growing knowledge of such networks to construct multi-component sensors and effectors to react to particular metabolic states in a cell, especially the aberrant states associated with disease. In this project, we aim to design modular gene n etworks of increasing complexity, that will sense errors at multiple levels in cellular pathways and will respond to repair the affected genes selectively. As a primary target, we have selected the p53 pathway; p53 itself is altered in ~50% of all cancers, while the other 50% of tumors carry alterations either in direct regulators of p53 (such as MDM2, p14ARF, E6 from HPV), or in pathways activating the p53 checkpoint (such as ATM, ATR, Brca1). Therefore we can consider that the p53 pathway is altered in v irtually every cancer. The global idea of the project involves designing a network that will detect 3 or more steps in the pathway, identify the step that is not working properly and then selectively respond, either by killing the cell or by repairing the affected gene through double-strand induced recombination. Thus, we aim to combine expertise from a systems biology and protein design group (Serrano), a cell biology group with experience in p53 pathways (Carnero), a company specialising in meganuclease-induced recombination (Cellectis) and a group specialising in viral vector delivery to cells and cancer therapeutics (Kühnel). By integrating the experience of these different groups, we expect to develop robust cancer sensors with therapeutic potential. F urthermore, by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An Illumination of the Dark Ages: modeling reionization and interpreting observations' (AIDA).

assistant: **Concept**

Understanding the dawn of the first galaxies and how their light permeated the early Universe is at the very frontier of modern astrophysical cosmology.  Generous resources, including ambitions observational programs, are being devoted to studying these epochs of Cosmic Dawn (CD) and Reionization (EoR).  In order to interpret these observations, we propose to build on our widely-used, semi-numeric simulation tool, 21cmFAST, and apply it to observations.  Using sub-grid, semi-analytic models, we will incorporate additional physical processes governing the evolution of sources and sinks of ionizing photons. The resulting state-of-the-art simulations will be well poised to interpret topical observations of quasar spectra and the cosmic 21cm signal.  They would be both physically-motivated and fast, allowing us to rapidly explore astrophysical parameter space.  We will statistically quantify the resulting degeneracies and constraints, providing a robust answer to the question, ""What can we learn from EoR/CD observations?"" As an end goal, these investigations will help us understand when the first generations of galaxies formed, how they drove the EoR, and what are the associated large-scale observational signatures.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Coupled mechanical and electronic properties of carbon nanotubes based systems' (1998-2002).

assistant: **Innovation**

All young researchers will have the possibility to profit by the standard Educational System available at each of the seven nodes. All these centres will have the possibility to offer specific training on the various aspects of the work programme periodically. Each young researcher will have the possibility to visit for short periods (5 to 10 days) each of the other partners, in order to get training on all aspects (experimental and theoretical) of the project. All young researchers will have the opportunity to participate in scientific meetings devoted to the proposal subject or any related topics. Individual training will be favored compared to common training. It must be noticed that each partner is a leading specialist in a given scientific domain and the corresponding node represent a particularly good environment for the young researchers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Assessing the socio-economic impact of environmentally sustainable redevelopment plans on communities housed in social housing estates in EU and US cities'.

assistant: **Concept**

Over the last decade, a new field of studies on ‘green gentrification’ has suggested a causal correlation between the implementation of environmentally sustainable planning initiatives and the displacement of low-income residents due to changes in property values resulting from environmental improvements. Such patterns are particularly alarming when 'green' development initiatives are implemented in disadvantaged neighborhoods with a history of concentrated poverty and social marginalization. In this comparative interdisciplinary study I will add to this growing body of literature by investigating the impact of 'green' redevelopment plans on the communities housed in three social housing estates in Europe and the US. I will conduct research in three cities –Berlin, London and Los Angeles – where three social housing estates, home to poor and marginalized communities, have been recently redeveloped as eco-friendly urban districts. My aim is to assess the extent to which these plans have encouraged processes of residential displacement of vulnerable households, including minorities and women, and if and what actions have been put in place to prevent them. My research objectives (RO) are: to examine the different politico-institutional landscapes in which the 'green' plans identified have been developed and operate in (RO1); to document the three redevelopment projects and the planning toolkits in use in each specific context (RO2); to quantify the socio-demographic impact of redevelopment, documenting residential turnover (RO3); to qualify the social impacts on the pre-existing public housing tenants through in-depth qualitative research (RO4). By shedding light on the dynamics of gentrification and displacement that may arise in social housing estates undergoing 'green'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Active Polymers for Renewable Functional Actuators', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The idea of mechanical actuator based on intrinsic material properties of liquid-crystalline elastomers (rather than complex engineering of interacting components) has been understood for 20+ years. The remarkable characteristics of LCE actuation (fully reversible action; large-amplitude, with a stroke of 5%-300%; stress-strain-speed response almost exactly matching the human muscle) make it highly attractive in biomedical engineering, robotics, smart textiles, and other fields. Yet, there is a profound difficulty (bottleneck), which remains the reason why this concept has not found its way into any practical devices & applications. LCE actuation requires alignment (monodomain structure) of the local anisotropy in the permanently crosslinked polymer network - which has been impossible to achieve in any useful large-scale configuration except the flat film, due to the unavoidable restrictions of two competing processes: orientational alignment and network crosslinking. Recently, we made a breakthrough, developing LCE vitrimers (polymer networks covalently crosslinked by a bond-exchange reaction). Vitrimers are much more stable than other transient elastomer networks, allow easy thermal re-moulding (making the material fully renewable), and permit molding of complex shapes with intricate local alignment (which are impossible in traditional elastomers). This project will bridge from the concept to technology, tuning the material design for robust nematic LCE vitrimers, imparting photo-actuation capacity with a controlled wavelength, and finally utilising them in practical-engineering actuator applications where the reversible mechanical action is stimulated by light, solvent exposure, or more traditionally - heat. These applications include (but not limited to): continuous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Determination of standardized parameters describing the electron transport for quantitative surface analysis by electron spectroscopies'.

assistant: **Concept**

Foreseen ResultsThe benefit of this proposal will be a software package for calibration curves and background correction of the elastic peak. A computer controlled data-base for transport mean free path and for selected systems derived from EPES will be elaborated. The new results obtained will be recommended to ISO TC 201 subcommittee and implemented by quality control in trade and by materials research.The proposal here presented aims at improving quantitative surface analysis by standardized physical parameters for calibration of measurement systems. Research and development to investigate the feasibility of new analysis methods are also included in the project. This program deals with quantitative compositional analysis techniques for thin film investigations and surface characterizations using electron spectroscopies.Objectives will be connected with possible technological applications because the development of new performant technologies associated to quality control are key factors of industrial progress.The program requires an interdisciplinary approach involving chemists, physicists and material scientistsProposed research topics are the following :1. Experimental determination of parameters and corrections for analysis methods of materials.- Determination of inelastic mean free path (IMFP) from measurements of elastic peak intensity, Monte Carlo analysis and development of software.- Determination of the values of transport mean free path (TRMFP).- Determination of the backscattering factor for AES on uniform and non uniform systems and its angular dependence.- Determination of Auger conversion efficiency factor based on elastic peak.- Shape and intensity of APS spectra for chemical informations2. Applying the above parameters in different procedures of surfa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Current Impact of Motorcycle Motorisation on Amazonian Indigenous Peoples' in the context of a Horizon Europe call.

assistant: **Objectives**

During the last century, the indigenous South American Lowlands have been colonized by steamboats, railways, trucks, chainsaws, fire-weapons and electric generators introduced by missionaries, extractive industries, armies, development projects, and NGOs. However, anthropological and historical research has largely neglected this mechanic colonisation of indigenous life by focusing on topics such as ideologies of personhood, kinship, cosmology, and relations with animals, religious missions and non-human spirits. Aiming at understanding social change, some studies have dealt with some of the new materialities that model everyday experience: t-shirts, outboard motors, solar panels, and cell phones. Nevertheless, not even a single study has analysed a conspicuous fact of the modernization of these marginal territories: the current tide of motorcycles that during the last few decades altered dramatically the interethnic landscape, and its social, economic and environmental repercussions which are significantly reshaping current indigenous reality. Therefore, the goal is to develop a ground breaking and interdisciplinary analysis of the effects of motorcycle dissemination among the indigenous peoples of Bolivian Amazonia, and to achieve practical impact regarding public policies on road safety and prevention of accidents in marginal contexts. By accomplishing the Work-Packages in my host institution Ca’ Foscari University (UNIVE), the project will therefore fill a significant gap in anthropological studies regarding indigenous modernity, while at the same time consolidating my position as a professor and researcher with updated capacities on visual and environmental anthropology, gender issues, science and technology studies, and digital humanities.


**Keywords:** ANTHROPO
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Linking neural circuits to visual guidance in flying flies' (FLYVISUALCIRCUITS).

assistant: **Innovation**

The brain of a fly is capable of steering the animal through a complex environment at high relative speeds, avoiding stationary obstacles and moving predators. Because it is relatively easy to study how flies do this at several levels, from the behavioral to the cellular, fly vision has long been recognized as an ideal system to address a fundamental question in neuroscience- how does the distributed activity of neurons orchestrate animal-environment interactions to result in successful coordinated behavior? This work addresses this basic question with two related studies. The first concerns higher levels of visual processing and behavior. Do flies build a neural representation of nearby objects or, alternatively, is flight governed by a direct coupling of visual input into motor commands? The second identifies specific neurons responsible for visual guidance behaviors.This work involves the establishment of a new research activity in the EU by a Principal Investigator who is moving from a third country (the US) into the EU. It uses a unique high-throughput, virtual reality free flight arena in which flies are tracked in realtime by a computer vision system. With this technology, physically unmanipulated and unrestrained flies are automatically and repeatedly presented with arbitrary visual stimuli projected on the arena walls and floor. Thousands of digitized 3D flight trajectories are gathered, and behavioral experiments using this system will be combined with targeted genetic manipulation of the nervous system and analyzed to reveal the magnitude and reliability of effects. This will be accomplished by using molecular genetic techniques to selectively perturb individually identified neurons in the brain and measuring the effect on flight control in response to precis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Predictive Techniques for System Level Analysis of Multi-Processors' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Emerging multi-processor products, such as Multi-Processor System on Chips (MPSoC), exploit concurrency to spread work around a system improving performance. European competitiveness in microelectronics such as wireless, networking, telecommunications, automobile, and consumer products relies heavily on improving reliability of such multi-processor systems. Electronic System Level (ESL) design methods and tools are important abstraction techniques to reduce complexity introduced due to concurrency; however, system level tools are still at their infancy. At the same time, traditional simulation based verification approaches fail to preserve concurrency that is inherent in such systems and suffer from the pitfalls of ad hoc specification. Similarly, formal verification is limited in its capacity and application domain.   In this project, we will develop system level analysis techniques to increase reliability of concurrent multi-processor systems. In particular, we propose to develop novel system level predictive runtime verification techniques that preserve concurrency information and exploit it to find both actual and potential errors from executions of system level models. At the same time, we will develop system level error diagnosis techniques and coverage metrics to ultimately reduce verification and debugging time. New research and tools will be developed with a focus on automation and scalability and experiments will be performed on industrial applications.