RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optical spectroscopy of Heusler compounds' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Heusler compounds, with a general composition X2YZ (with X, Y being a transition metal and Z an element from the III-V groups) are attracting an interest due to their possible use in the novel field of spin-dependent devices, also known as spintronics. This interest in Heusler compounds comes from the half-metallic character of their spin-split band structure, i.e. metallic behavior for one spin component, and insulating behavior for the other one, as predicted by ab-initio calculations for many compounds of this material class. As such, these materials may exhibit a 100 % spin polarization at the Fermi level, which would make them ideal candidates for e.g. spin polarizers or spin detectors. An important force to be understood in detail in those materials is the spin-orbit coupling, which provides interaction between spin and the lattice. As such, the spin-orbit coupling is an underlying force for many important effects, such as Hall effect, spin Hall effect (and their inverse variants), spin diffusion length, Gilbert damping etc. Therefore, here we propose to investigate spin orbit coupling of the first and the second order in the Heusler compounds using optical and magneto-optical Kerr effect (MOKE) spectroscopy of the first (longitudinal MOKE) and the second (quadratic MOKE (QMOKE)). Furthermore, we want to investigate Heusler compounds using infrared (IR) spectroscopy and MOKE-IR spectroscopy, as those probe spin-orbit coupling in the vicinity of the Fermi level. Note that QMOKE spectroscopy has never been realized yet and that IR-MOKE is an unique technique in the world scale.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of caveosome-medicated endocytosis during MMP-2 activation' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

The turnover and remodelling of extra cellular matrix (ECM) is an important feature after vascular injury in noontime formation and remodelling of the injured vessels. Collagen is the major ECM protein and can only be degraded by the matrix metalloproteases (Mumps). Broad spectrum MMP-inhibitors can prevent arterial shrinkage and noontime formation but suffer from severe side effects after prolonged administration in humans. To find a specific target(s) for intervention, we have to understand how turnover of collagen is regulated. Collagen degradation is dependent on the action of several matrix metalloproteinases and MMP activity is regulated at multiple levels. The expression ofMT1-MMP, MMP2 and MMP-9 are early unregulated in time after vascular injury. Although, the activation of MT-1MMP(MMP2) takes place on the cell surface the compartmental basis for integrating the Tran membrane signalling underlying the MMP2 activation cascade into cells remains to be established. MMP2, MT1-MMP and TIMP-2 are co-localized with Caveolin-1, a major constituent of theCaveolae. The cellular functions of Cavalla are not yet fully understood. Recently, the study of sub cellular distribution of carboxyl-terminally green fluorescent protein GFP-tagged Cav-1 (Cav-1-GFP) revealed that this protein has high mobility within cells. Cav-1 can be found at the cell surface, associated with Googly complex and present in alveolar vesicles. Cav-1,moves bi-directional between the cell surface and cell interior. Several reports have shown that certain viruses, lipid-bound toxins and certain glycosylphosphosphatidylinositol (GPI)- linked proteins enter cells and are sorted to different sub cellular locations bypassing endoscopes using a recently described organelle (termed the \Cave some\"). This orga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of tissue-resident FOLR2+ Macrophages as Organizers of the Tumor Immune MicroEnvironment', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The infiltration of CD8+ T cells in tumors is crucial for the development of immunity against cancer. We have recently identified a tissue-resident macrophage population expressing the folate receptor 2 (FOLR2) and infiltrating human and murine breast tumors. We have shown that tumor-infiltrating CD8+ T cell form lymphoid aggregate around FOLR2+ macrophages in a perivascular niche. The abundance of FOLR2+ macrophages associates with lymphocyte infiltration, the onset of tertiary lymphoid structures (TLS) and favorable prognosis. The abundance of TLS in cancer correlates with better prognosis and clinical response to immunotherapy. Yet, the molecular and cellular cues underlying TLS formation in tumors are ill understood.  Here we hypothesize that FOLR2+ macrophages locally shape the compartment of tumor-infiltrating CD8+ T cells. Mechanistically, we will address if FOLR2+ macrophages spark local CD8+ T cell responses directly, by interacting with T lymphocytes or indirectly, by fostering TLS formation.  To this end, we will (1) develop a high dimensional analysis of the FOLR2+ macrophage-perivascular niche using tissue imaging, spatial transcriptomic and single-cell RNA sequencing; (2) implement a new murine genetic model developed in the lab enabling the inducible ablation of FOLR2+ macrophages and conditional gene inactivation; (3) deliver a mechanistic analysis of cellular cross-talks involving FOLR2+ macrophages and supporting the development and maintenance of TLS. Lastly, we will explore new immunotherapy strategies harnessing the immunogenic function of FOLR2+ macrophages purposed to induce anti-tumor CD8+ T cell responses. To this end, we will use antibody-mediated targeting of FOLR2+ macrophages to increase antigen presentation and/or innate activation.  This s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mitochondrial DNA homeostasis in growing cells' (MITOSIZE) under Horizon Europe.

assistant: **Objectives**

Mitochondrial DNA (mtDNA) constitutes a substantial proportion of DNA in eukaryotes, and its regulation is critical not only for mitochondrial function but also for cell survival. However, it is still unclear how mtDNA copy number is maintained during cell proliferation and how mtDNA copy number impacts on cell function. Recently, my group showed that in budding yeast, mtDNA copy number is tightly linked to cell volume to maintain constant concentrations, providing an elegant and potentially conserved strategy for mtDNA homeostasis. But how is mtDNA coupled to cell volume? Based on my group’s work, we proposed that nuclear-encoded mtDNA maintenance factors produced in proportion to cell volume limit mtDNA replication and stability. This provides a conceptual mechanism for how cells link mtDNA copy number to total cellular protein content, and opens the door to a quantitative and molecular understanding of mtDNA homeostasis.With MITOSIZE, I will reveal the molecular basis of this ‘limiting machinery’ mechanism. To test whether the mechanism is conserved across species and to chloroplast DNA, I will use two evolutionary distant eukaryotes: S. cerevisiae, whose size I can control genetically, and C. reinhardtii, whose size I can control with light. I will use an interdisciplinary approach combining molecular biology, quantitative live-cell imaging, and modelling to develop a quantitative understanding based on measurements of mtDNA replication and degradation. I will then unravel the contribution of the ‘limiting machinery’ regulation to the dynamic adaptation of mtDNA to changing environments. Moreover, by breaking the coupling of mtDNA copy number to cell volume, I will dissect how cell volume and mtDNA copy number determine cell function and aging. By identifying the mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'molecular and functional characterization of EmergiNG INflammasomES', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Inflammasomes play a pivotal role in host defense. They function as intracellular surveillance systems by sensing pathogens or indirectly by responding to the perturbation of cellular homeostasis. While our understanding of inflammasome biology is growing at a rapid pace, we still have an incomplete understanding of how these systems detect pathogenic insults, or how these sensors operate at the molecular level. Just recently, NLRP1 and the closely related CARD8, a functionally distinct subgroup of inflammasome sensors, have been ‘de-orphanized’ for their unique mode of action. More than other sensors of the inflammasome family, NLRP1 and CARD8 display a high level of divergence across different species and NLRP1 ranks among the top genes experiencing positive selection in primates. In our search for a physiological NLRP1 trigger, we have now made the surprising finding that human NLRP1 operates as a direct sensor for dsRNA, a key non-self signature of viral replication.To obtain a detailed mechanistic framework for NLRP1 and also CARD8 function, I here propose a challenging and pioneering endeavor: employing functional genomics, proteomics and chemogenomics, we will identify signaling networks upstream of NLRP1 and CARD8. Taking cell biological, biochemical and structural biology approaches, the mechanism of action and structure of these sensors will be elucidated. Further, screening a large panel of pathogens, we will characterize their role in response to infection in vitro and implementing novel humanized mouse models for the NLRP1 and the CARD8 inflammasomes, we will assess the relevance of these sensors for antiviral immunity and immune cell homeostasis in vivo. Altogether, this work will not only comprehensively profile the role of these emerging inflammasome pat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dispersals, resilience, and innovation in  Late Pleistocene SE Africa' (DISPERSALS) targeting Horizon Europe.

assistant: **Abstract**

Genetic evidence suggests that successful modern human migration out of Africa is believed to have started c. 70,000 years ago, populating the whole world, at different rates and times. This incredible voyage took place because of humans unique resilience, versatility, and innovation, both biological and cultural, to external stimuli, including ecological and environmental changes. The main objective of DISPERSALS is to investigate the migration and dispersal dynamics of early Homo sapiens in Africa and archaeologically evaluate the genetic model that southern African human populations were the genesis of the successful out-of-Africa some 70,000 years ago. This will be accomplished by investigating cultural and biological continuity/discontinuity issues and human population movements in the last c. 100,000 years in the poorly studied Limpopo and the Save river basins, central Mozambique, an area mediating the two key regions of human development, i.e., southern and eastern Africa.DISPERSALS will compare the human occupation and ecology between central Mozambique and eastern and southern Africa using a multi-scale approach based on the study of regional diachronic cultural traits. It will reconstruct regional population patterns, followed by comparative quantitative population genetics combined with GIS computational network analyses. The results will be then integrated through Agent-based modeling, based on the incremental creation, elimination, or reorientation of network links to simulate a quantitative framework to study the evolution of population dispersal across southern-eastern Africa. The project will be crucial in providing ground-breaking high-resolution archaeological, chronological, and paleoenvironmental data. DISPERSALS will deliver a fundamental perspecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Advanced Multidisciplinary Research for Antimicrobial Resistance'.

assistant: **Innovation**

We are proposing a 4-year program of knowledge transfer and networking between academic institutions [University of Leicester (UK), University of Valencia (Spain), International Iberian Nanotechnology Lab (Portugal), University of Bologna (Italy), University of Aveiro (Portugal), Fudan University (China), and Alfred University (USA)] and industrial partners [Teer Coatings Ltd (UK)].  The objective of the proposed joint exchange programme is to establish long-term stable research cooperation between the partners with interdisciplinary expertise and knowledge to develop Advanced Multidisciplinary Research for Antimicrobial Resistance (AMRAMR), including the development of novel antibacterial nanomaterials and nanostructures, novel antibacterial thin films coatings, upconversion technology for AMR applications, photonics technology for AMR application, and evaluation of the antibacterial performance and antimicrobial resistance; the synergetic effect for the above approaches to understanding antimicrobial resistance.  Antimicrobial resistance (AMR) refers to the ability of microorganisms, such as bacteria, viruses, fungi, and parasites, to resist the effects of antimicrobial drugs, such as antibiotics, antivirals, antifungals, and antiparasitics. AMR is a serious global public health threat that could lead to increased morbidity, mortality, and healthcare costs.World Health Organisation (WHO) has declared that AMR is one of the top 10 global public health threats facing humanity.  The COVID-19 pandemic has highlighted the importance of AMR as it has led to increased use of antimicrobial drugs, particularly antibiotics, which can contribute to the development of AMR. People with COVID-19 may develop secondary bacterial infections, such as pneumonia, and may be prescribed an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Body Societal: Unfolding Genomics Infrastructure in Cattle Livestock Selection and Reproduction' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Genomics technologies promise to shape the ideal animal of the future. Social sciences so far mostly took interest in the medical domain with the Human Genome Project and its aftermath. However, a great deal of fast-pace developments are occurring in livestock genomics. This has become a mundane genomics infrastructure, routinely used in late capitalist societies. This infrastructure offers to solve pressing societal issues, such as improving the health of animals, lowering their environmental impact or enhancing the biodiversity. Focusing on the case of cattle livestock, The BoS project aims to describe and analyze how societal values are being translated in bovine bodies. It asks the following guiding research questions: how are such values as health, environment or biodiversity incorporated in cattle selection and reproduction? Conversely, how are bodies transformed by these values, and through which techniques and practices? To answer those questions, The BoS project will provide a political anthropology of the genomics infrastructure, contributing to sociology of scientific knowledge, science & technology studies and environmental humanities. Phase 1 carries out three laboratory ethnographies in centres of scientific excellence that contribute to global livestock genomics, so as to provide context-sensitive accounts of how values of health, the environment and biodiversity are turned into knowledge. Phase 2 follows the knowledge in the wider world of social actors, carrying out participant observations and semi-structured interviews, to question the transformation of cattle bodies by genomics. The project is very innovative as livestock genomics offers an unprecedented case study of actual applications of genomics knowledge. Three PhD students will be respectively
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Computational Literary Studies Infrastructure' in the context of a Horizon 2020 call.

assistant: **Objectives**

The CLS INFRA project brings together and further develops institutional, national and regional efforts to build shared and sustainable infrastructure - high-quality data, tools and knowledge needed to undertake literary studies in the digital age.  The resulting improvement in provision will benefit researchers by bridging gaps between greater- and lesser-resourced communities in computational literary studies and beyond.  It is a particularly opportune moment for this activity, as projects across the literary genres have defined the requirements for such and infrastructure and organised the user community to be ready to use it.    The landscape of literary data is currently very heterogenous, with the long and varied tradition of digital libraries meaning that while many resources are available, they are far from standardised in terms of how they are constructed, accessed and the extent to which they are reusable.  CLS INFRA deploys strategies to align these diverse resources with each other, with the tools needed to interrogate them, and with a widened base of users able to create knowledge with and from them.  It builds interoperability that integrates common and less common standardisation approaches, workflows to help researchers create, access, share, link, analyse, and interpret heterogenous data across languages and sources; and tools for accessing, harmonising and analysing data, all within a robust suite of stable technical approaches and standards.The project is delivered by a geographically balanced, complementary transnational consortium of key local and national infrastructure providers, covering the full range of the projects defined areas for integration and innovation and aligned so as to create a common infrastructural approach for computational liter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integrated assessment and Advanced Characterisation of Neuro-Nanotoxicity' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

The incidental, accidental, or intentional release of manufactured nanomaterials into the environment and its exposure to humans is inevitable due to the exponential growth in invention, production, and use of them. It can have a huge impact in our health specially in the most sensible and exposed human body organs such us lungs, stomach, and brain. iCare aim to to develop a resilient and adaptive set of advanced imaging technologies to quantify physical-chemistry properties for ANMC in complex matrices. The main objective will focus on a integrated model system to characterize and predict the impact of nanomaterials on brain health to prevent the toxicity nanomaterials. The project makes accessible for industry a set of techniques and methodologies to evaluate changes in morphology, chemical composition and reactivity of nanomaterials when exposed to complex homogenous matrices mimicking environmental and biological exposure, with a particular emphasis on high-resolution imaging methodologies.To achieve this goal the project the project brings together in the consortium 11 partners from different backgrounds such as RTOs, SMEs, industries and universities from different EU and non-eu countries and coming from different fields like nanotech, toxicology, advanced materials, advanced imaging, …During the 48 months long of the project, the consortium will work on the development of different activities to achieve the following results: 1)new imaging methods achieving new high resolution methodologies and new super resolution imaging techniques 2)development of toxicology testing protocols and addressing current gaps in nanotoxicology, 3)development of tools and methods bringing the gap in vitro and in vivo testing, 4)efficiency of materials and product development 5)Delive