RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lacewing venom: Linking the molecular and phenotypic evolution of adaptive traits' (VenomEvolvability), addressing dissemination and exploitation.

assistant: **Impact**

Understanding the ability of species to adapt to their environment, or their evolvability, is central to evolutionary biology. Most traits are complex in that their phenotype results from the contributions of many genes with small, sometimes non-additive effects. While quantitative genetics has been instrumental in showing that short term evolvability depends on additive genetic variation, it ignores details of the molecular underpinnings of phenotypic characters that are crucial for the production and maintenance of additive genetic variation, and therefore evolvability at longer time scale. This impacts our understanding of evolvability and calls for model traits that enable the integration of quantitative and molecular genetics. Venoms are great model systems for this purpose. They are convergent sets of traits well-suited for comparative studies, and their phenotypes result from the combined actions of a relatively small number of secreted, functionally repurposed proteins, or toxins, that can be identified, characterised, and quantified. This project focuses on the venoms of Neuroptera, which venoms remain unstudied despite providing a unique opportunity among venomous animals to combine omics techniques, and comparative molecular and morphological evolution with evolutionary quantitative genetics. This multidisciplinary approach will elucidate the genetic and evolutionary mechanisms that underlie the emergence of venoms as complex evolutionary novelties and identify the molecular properties that facilitate or constrain their evolution across micro- and macroevolutionary timescales. Thus, the project will test central hypotheses about venom evolvability, but it is also likely to yield novel bioactive molecules with potential use as molecular tools and agrochemical
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single or few molecules detection by combined enhanced spectroscopies' (SMD).

assistant: **Concept**

Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Degradable Polyolefin Materials Enabled by Catalytic Methods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Plastics are essential to virtually any modern technology and therefore ubiquitious. However, when released to the environment they can persist for centuries. One pillar of a responsible future economy is therefore to endow important plastics with a non-persistent nature. Polyethylene (PE) is the largest scale synthetic material, used in transportation, energy storage, water cleaning, clothing and many other fields. However, it is most problematic concerning degradability.  This proposal addresses this major challenge by introducing photo- and hydrolytically degradable groups in the PE chain. Directly during catalytic PE synthesis, isolated keto groups will be generated by incorporation of small amounts of carbon monoxide. This yet unachieved goal is targeted via catalysts with extreme shielding and rigid ligand environments in heterobimetallic Ni(II) / main group metal complexes. A compartmentalized aqueous polymerization with precise control of high ethylene/CO ratios will yield the in-chain functionalized PE as nano- and microscale particle dispersions. Living catalytic polymerization in nanoparticles is pursued to achieve ultra high molecular weights and gradient PE chains forming nanodomains varying in ketone density. Aqueous heterophase oxidation with benign oxidants on all these nanoparticle will yield in-chain ester groups. Further types of hydrolytically cleavable groups are targeted via the complementary synthetic approach of step growth from seed- or microalgae-oil derived PE-telechelics. This yields linear PE with in-chain carbonate, acetal and anhydride groups. Basic materials properties of all polymers are determined by tensile tests. Degradation studies reflecting a marine environment will indicate the persistency behaviour and fate of microfragments, usi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Extreme Quantum Matter in Solids' (ExQuiSid).

assistant: **Concept**

Quantum stochastic processes in solids, representing many-body systems par excellence, are believed to lead to extreme forms of quantum entanglement and non-local correlations (extreme quantum matter), that offer a well-defined starting point for an understanding of a wide range of anomalous materials properties, as well as emergent electronic phases such as magnetically mediated superconductivity or partial spin and charge order. While overwhelming experimental evidence clearly suggests a breakdown of traditional concepts such as well-defined quasi-particle excitations, the striking present-day disagreement between experiment and theory may be traced to the lack of experimental information on the spectrum of quantum stochastic many-body processes in solids in the low-energy and low-temperature limit close to and far from equilibrium.ExQuiSid will advance the understanding of the nature of extreme quantum matter in the most extensively studied model systems, notably simple magnetic materials (insulators and metals) tuned through a quantum phase transition. For the proposed studies my group has implemented a new generation of methods covering for the first time neutron spectroscopy with an unprecedented nano-eV resolution even under large magnetic fields, transverse-field vector magnetometry, calorimetry and transport down to milli-Kelvin temperatures, and, ultra-high purity single-crystal growth combined with advanced materials characterisation. ExQuiSid will (i) solve long-standing mysteries in model-systems of extreme quantum phase transitions, (ii) experimentally enable and permit pioneering studies on the creation, nature and classification of non-equilibrium quantum matter in solids at ultra-low energies and temperatures, and (iii) experimentally enable and permit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synchrotron Miniaturization enabling Innovative Laboratory Equipment in soft x-ray tomography.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of SMILE is to support SiriusXT in moving a prototype of its soft x-ray microscope (SXT100) from prototype to commercial product through addressing ease-of-assembly, manufacturing scale-up, serviceability, customer pilots, regulatory pathways and business model requirements. The disruptive innovation delivered by SMILE is to open up the market for soft x-ray imaging from approx. 100 users today to an immediate target addressable market of over 3,000 disease research and drug discovery organisations by reducing the cost of the microscope assembly by a factor of over 200 (from over €500 million to €2.5 million) and miniaturizing its size, by a factor of 5,000 (from 15,000m2 area to approx. 3m2). Soft x-ray imaging is the only means available today of generating high resolution, high contrast, 3D images of the internal structure of whole biological cells in their near-natural state. Cell researchers currently spend approx. €500m annually on electron and optical microscopes in order to increase their understanding of subcellular structure and how this relates to disease progression and therapy, however neither of these technologies is capable of imaging the whole internal cell structure. The SXT100 gives disease research and drug discovery organisations daily access to a soft x-ray microscope in their own labs, rather than having to queue for often more than six months to get a few hours of access to one of only four synchrotron locations around the world where a suitable soft x-ray source and microscope exists today. The SXT100 will not only increase a researcher’s productivity 100-fold, in the number of biological cells they can image, but it also allows them to carry out a range of disease progression studies, not possible today because of the restricted access t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Transcription mapping and comparative analysis of the distal mouse x chromosome' (1994-1998).

assistant: **Innovation**

Abstract The distal short arm of the human X chromosome (Xp22.3), which includes the pseudoautosomal region, appears to be highly divergent from its alleged murine counterpart. Genes isolated from this region of the human X are either not conserved in mouse, or they show an autosomal location in the mouse genome. Most strikingly, the CLCN4 gene is X-linked in human and Mus spretus but maps to chromosome 7 in C57BL/6 laboratory mice. The high evolutionary divergence of this region in eutherian mammals may be in part due to the occurrence of obligatory crossing-over events in the pseudoautosomal region during male meiosis, which leads to a higher frequency of double strand breakage and repair and subsequently to a high mutation rate. The region of the mouse X chromosome syntenic to human Xp22.3 is poorly characterised. We propose to construct a transcription map of this region, characterise the cloned genes, and subsequently identify any homologues of human genes through the comparison of protein sequences. We are particularly interested in isolating the murine homologue of the Kallmann syndrome gene (KAL) as this will aid colleagues at the host institute in their study of the role of the KAL protein in mammalian neuronal migration. Comparison of the mouse and human maps of this region, particularly around the pseudoautosomal boundaries, will provide valuable insights into eutherian sex chromosome evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A 2 MW WINDFARM WITH ATTENTION TO VISUAL INTRUSION' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The aim of the project is demonstrate the first commercial windfarm application of the high efficiency T400 turbine in a 2MW windfarm in such a manner that the maximum amount of power is generated at the least height. The siting of the turbines aims are to minimise visual intrusion for the more rugged areas that surround the site. In this manner it is expected to increase the public acceptability of wind turbines as usefully contributing to the environment at least impact.It will use 5 x 400 kW free-yaw turbines to produce electricity. The production output is 48% higher than the T300-28 due to the innovative design and active stall principle. The power curve is flat from 13.5 m/s to 25 m/s. The active stall regulated wind turbine does not need to be braked when not running which decreases the loads on blade and drive train mechanism. The blades can rotate freely when not running; there is adapted appropriate rotor hardware and software to achieve this. When running the windturbine will free-yaw which decreases the load on the complete structure- all other turbines use yaw brakes. The nacelle will not be braked on its tower but smoothly follow the wind; this steady soft free-yaw nacelle system is achieved by using special software. The reduced stress on the tower support enables a more innovative tower of less size and weight to be used.Context in which the technology is operating : The 2MW windfarm will be located in Burren, Castelbar, Co.Mayo Ireland. The turbines will be located to produce the maximum output consistent with fitting harmoniously into the landscape. The energy efficiency of the electrical system will be optimised by keeping losses to a minimum.The economic aspects of the technology: the cost of the T400-34 produced in series is expected to be only 5% h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regulation and information acquisition' under Fourth Framework.

assistant: **Concept**

Research objectives and content The New Regulatory Economics focuses on the design of the optimal regulatory mechanism when the regulated firm has private information about the environment (e.g. exogenous cost and demand conditions) and her own characteristics (e.g. managerial effort). In this field of research the information structure has almost always been assumed exogenous, and beyond the control of the central planner.  My aim is to analyse: (i) how the regulator should design the optimal regulatory mechanism taking into account firms' incentive for information acquisition when perfect information acquisition is prohibitively costly (ii) how the optimal organisation of the industry is affected by the information acquisition problem, and (iii) when the acquisition of information should be delegated to the firm and when instead it should be centralised. To my knowledge these issues are almost unexplored. Training content (objective, benefit and expected impact) In a fruitful environment like the one in ECARE I hope to improve my knowledge of contract theory and mechanism design and hence gain a better understanding of the reasons why in some circumstance the regulatory mechanisms delegate decisions to the firm (e.g. in terms of quality) and in some others they do not and how these choices are related to the information acquisition problem If I am able to get results on the ideas mentioned above, this should be interesting for firms in regulated industries, for policy makers who aim at promote efficiency in these industry and for consumers, whose preferences and attitudes are often the object of data collection from the firm's side. I hope that the results measured in amounts of literature will be 2 articles that are suitable for publication in international journals
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of pertraction to remove organics from waste/process water and to enable re-use/recycling' (1998-2002).

assistant: **Innovation**

Emissions of organic pollutants to waste and or process water are a serious threat for the environment, limit recycling possibilities of water and can form a loss of organic chemicals. Per traction is a new very efficient membrane based extraction process which enables both removal of organics from water with a high removal efficiency and also recovery of the organics in a pure form. In the project two SME - Original Equipment Manufacturers (OEM's) specialized in membrane equipment together with an RTD performer will access the technical and economical feasibility of per traction. Per traction equipment will be developed and tested on site of end users to demonstrate the feasibility of the technology and to determine optimal areas of application. Apart from the development of highly efficient, flexible, compact and cost effective equipment the objective is also to gain confidence of Potential end users in Pharmaceutical, Off Shore, Automotive, Paint, Petrochemical and Chemical Industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Identification and characterization of a novel damage sensor for cytoskeletal proteins in Drosophila'.

assistant: **Concept**

Inflammation is a host response that evolved to counteract noxious stimuli that result from infection or tissue injury, and serves to return the affected tissue to homeostasis. Cell death-associated sterile inflammation is a major contributor to secondary tissue damage associated with multiple conditions such as myocardial infarction, transplantation, and stroke. Damaged tissues are thought to elicit their inflammatory effects through the sudden release from cells of endogenous Damage-Associated Molecular patterns (DAMPs) that serve to recruit and modulate the function of immune cells. In vertebrates, a diversity of molecules have been implicated as DAMPs, including ATP, uric acid, and F-actin. In mammals, F-actin is recognised as a DAMP by the C-type lectin receptor DNGR1, expressed on CD8+ Dendritic cells (DCs), that signals to favour the cross-presentation of dead-cell antigen to CD8+ T-cells. Independently of its work on DNGR-1, the host laboratory discovered that extracellular actin elicits a JAK-STAT-dependent inflammatory response in the fruit fly (Drosophila melanogaster). DNGR-1 does not have a functional homolog in fly, therefore the actin sensor remains obscure. In order to identify the molecular sensor of extracellular actin we have conducted an in silico-based screen to identify a candidate list of potential sensors. To functionally evaluate these candidates, we will conduct in vivo RNAi and in vitro gain-of-function screens in Drosophila. We will validate the role for this novel sensor in mediating sensing of extracellular actin through multiple genetic and biochemical approaches. We expect our proposal to give novel insights into the signalling transduction and immunobiology of host responses to evolutionary conserved DAMPs. We anticipate that by understa