RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigation into emerging, evolving or novel viruses of swine in respiratory, reproductive and enteric pathologies: horizon scanning for risks to swine health and food security' under Horizon 2020.

assistant: **Concept**

Emerging viruses pose a significant threat to animal health and welfare, food security and rural prosperity. When porcine circovirus 2 (PCV2) emerged in the late 1990s after circulating in pig populations for at least several decades before.  The associated disease post-weaning multisystemic wasting syndrome (PMWS) is estimated to have cost the EU over 600 M euros per year at its peak. The emergence of a highly pathogenic strain of porcine epidemic diarrhoea virus (PEDV) in the US and Asia has resulted in the death of millions of pigs and the economic costs are still being counted. Here we propose a research project that will increase our understanding of emerging, evolving or novel viruses in swine in order to allow assessment of and improved response to, current and future socioeconomic threats to the European agri-food industry. This project aims to: (1) Develop, enhance and apply a range of classic and beyond the state-of-the-art diagnostic methods for the detection of emerging, evolving or novel viruses in swine in a world-class institute with a long history of successful virology research including identification and commercialisation of PCV2; (2) To statistically establish disease association of detected viruses with these considering viral load aspects of infection; (3) To statistically establish disease association of combinations of virus in co-infection scenarios; (4) To develop next generation sequencing (NGS) methods to allow characterisation of the entire viral flora of pigs with particular disease states; (5) To parallel these research activities with a comprehensive, multi-disciplinary training programme including laboratory and non-laboratory scientific and IT skills as well as training in a range of professional skills to provide a competitive advantag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unwanted Invaders or Welcomed Guests: Impact of Prophage Integration Sites on Host Genomic Integrity and Evolution' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bacteriophages are found in over two-thirds of sequenced bacterial genomes, with phage DNA making up an estimated 10% of these genomes. Recent studies suggest that phage DNA integration, during so called lysogeny, can lead to interactions with bacterial hosts that are more complex than once thought. There are phages which very specifically and reversibly integrate into host genes, modulating host development. Altering bacterial behaviours can have detrimental consequences in microbial communities, such as those found in the human gut. However, it is unclear how specific phage integration mechanisms evolve, or if integration specificity influences regulation during lysogeny. I hypothesise that phage integration components are a key factor in phage-host interactions, with attachment sites (att) and phage integrases under strong evolutionary pressure. This project's goal is to examine the consequences of specific phage integration for the host and for the phage and to understand how integration components are directed by evolution. This will be fulfilled via three research objectives: 1) bioinformatics analysis of phage integration components, capitalizing on newly built prophage database and focusing on conservation of host att genes and phage integrases; 2) investigation of the effects of integrase specificity on phage-host interactions and fitness via combining engineered phages and trackable host with high-throughput imaging and RNA sequencing. 3) testing the long-term effect of specific att sites on host genome evolution in ecological context to Bacillus subtilis was selected as the model host due to its tractability, biotechnological importance, and susceptibility to phages with highly specific integrases. Understanding the impacts of phage integration specificity an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of Fast Timing tools for Event Reconstruction at the high luminosity frontier' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

High luminosities at future particles colliders, such as the High Luminosity Large Hadron Collider (HL-LHC), will come at the price of a dramatic increase in the number of concurrent interactions of beam particles (referred to as pileup) per crossing in the experiments, implying serious challenges to the reconstruction of events. Due to the spread of the proton bunches along the beamline, collisions vertices at the HL-LHC are spread out over about 5 cm along the beam direction and about 160 ps in time. At the vertex densities foreseen at the HL-LHC, some vertices and the associated particles are so close to be merged by the track reconstruction forming fake jets of high transverse momentum. Moreover, the random overlap of energy deposits from neutral particles (mainly photons), that cannot be tied via a track to any vertex, will deteriorate the calorimeter performance in terms of energy measurement and particle identification, as particles appear to be less isolated. A promising tool advocated to mitigate the effects of pileup consists in complementing the high transverse (spatial) granularity of the detectors with extreme time resolution (of the order of 10 ps), that would allow energy deposits coming from different interaction vertices to be resolved in time.The goal of this project is the definition of a viable way to exploit precision timing in event reconstruction at HL-LHC and integrate and/or complement the calorimeter system of the Compact Muon Solenoid (CMS) with ultimate timing capabilities. The project will address both software aspects, with the development of innovative and dedicated algorithms for event reconstruction in 5 dimensions (space-time and energy), and hardware aspects, with the study of microchannel plates as candidate sensitive detector for a d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Spatially explicit mechanisms of Recent EVOLution in an African biodiversity hotspot' (REVOL) targeting Seventh Framework.

assistant: **Abstract**

Biodiversity hotspots are regions where exceptional concentrations of endemic species face extraordinary levels of habitat loss. The evolutionary processes determining the genesis and maintenance of such high biodiversity are poorly understood. REVOL uses population genomics in a multi-disciplinary context to uncover the neutral and adaptive evolutionary processes responsible for recent and ongoing plant species diversification and persistence in the Cape Floristic Region, a biodiversity hotspot in South Africa. Restriction Site Associated Sequencing (RAD-Seq) and chloroplast DNA sequences will be used in two Restionaceae and two Proteaceae species. Range-wide phylogeographic structure analysis, coalescent modelling of demographic history and tests for range dynamics will inform on neutral processes – genetic drift, neutral mutations and gene flow patterns – in each taxon. On this demo-historical background, neutrality and outlier tests will identify candidate genes under selection and Bayesian geographical analysis will establish gene-environment correlations. Analysis of spatio-temporal congruence of neutral processes across taxa and comparison of adaptive processes will inform wether populations and species have undergone parallel selection, similar demography, or shared phylogeographic history. The application of innovative technology and analytical methods to original biological study groups will yield novel evolutionary insights. Identification of drivers of recent evolution will improve environmental niche modelling predictions under climate change, leading to better management for conservation and sustainable use of African biodiversity, which will enable socio-economic benefits. REVOL will increase the applicant’s competitiveness for career consolidation throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'I European Telecommunication Summer School' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

One of the most important problems for the deployment of third generation mobile systems in Europe is the lack of engineers with expertise in this technology. The aim of the seminar is to present the standards and technology of the third generation of mobile communications systems. It will contain an overview of the research projects in Europe followed by a presentation of the ETSI standard; WCDMA/UMTS; and technology, methods and tools for cell planning. Courses will be provided by major manufacturers and telecom operators as well as academic sources. The seminar will be set at the level of a post-graduate course and will train about 100 engineers in the two-week course.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Optimizing Second Language Learning: An Examination of Individual Differences in Speech Processing and their Role in Language Learning' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Even though multilingualism is highly prevalent in Europe, those who speak a second or third language often differ substantially from native speakers in ways that hinder efficient communication. Despite it being acknowledged that individual differences play a critical role in learning a foreign language, the majority of research has focused on a narrow subset of factors such as learning strategies and personality traits. OptiSeLL aims to expand this exploration by looking at individual differences in phonological processing and the role they play in second language acquisition.OptiSeLL is based on recent findings from basic research in psycholinguistics showing that listeners differ substantially in how they process the speech signal. Our aim is to expand these novel findings and assess the degree to which they can be applied to second language learning. OptiSeLL specific objectives are to:1. Examine whether individual differences in speech processing affect the acquisition of new phonological contrasts.2. Examine whether such differences can also affect novel word learning.3. Assess the degree to which exposure to different phonetic systems may lead to a more flexible speech processing.In other words, this project will take advantage of the existing individual variability to identify the key factors that facilitate second language learning, possibly through the development of flexible speech perception systems. Once known, we can then explore how we can manipulate these factors to design educational environments that support flexible communication and efficient language learning. In addition, the findings of this project will be of high theoretical significance to the field as they will considerably advance our understanding of basic speech perception mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Predicting potent drug combinations by exploiting monotherapy resistance' under Horizon 2020.

assistant: **Concept**

Personalising treatments based on tumour genetic profiles enables cancer precision medicine. However, treating cancers using targeted therapies often fails due to the emergence of drug resistance. Here, my goal is to use drug high-throughput screens (HTS) combined with computational methods to identify resistance and its biomarkers, and to overcome it with smart drug combinations to empower cancer precision medicine.Identifying resistance in HTS is challenging: dissecting meaningful drug responses at high concentrations is impossible due to cytotoxicity, making non-responders and resistant cell lines indistinguishable, thus limiting resistance biomarker discovery to frequently mutated cancer genes. To address this, I will employ three approaches: 1) systematically identify non-responding cell lines carrying low-frequency resistance markers; 2) reveal intrinsic resistance driven by gene expression plasticity by conducting my own RNA sequencing experiments and modelling the maximal effect at high drug concentration; 3) identify drugs which increase cell viability, combined with drugs targeting fast proliferating cells. My paradigm shift, that resistance biomarkers become synergy markers, empowers smart drug combinations.Additionally, I aim to predict drug synergy based on multi-task deep learning using molecular characterisation, QSAR modelling and monotherapies; and, to boost biomarker discovery by identifying clinically-relevant cancer subtypes based on transfer and reinforcement learning.COMBAT-RES will benefit from data access to a phase III clinical trial in colorectal cancer (COREAD) and access to the largest human pancreas adenocarcinoma (PAAD) combination HTS (currently unpublished) accelerating the delivery of medicine for COREAD and PAAD patients. COMBAT-RES wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Boosting European citizens knowledge and awareness of bioeconomy' (BLOOM), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of this project is to establish open and informed dialogues, co-created by European citizens, the civil society, bioeconomy innovation networks, local research centers, business and industry stakeholders and various levels of government including the European Commission. BLOOM will elaborate five hubs (communities of practice) that will allow for an iterative process that involves with all stakeholders through various cycles of value development, enabling cross-fertilization and idea generation through shared knowledge and experiences. In co-created workshops outreach activities will be designed, explored and validated that are exactly adapted to the regional needs of the stakeholders. The interactions aim to (a) raise awareness and knowledge on bioeconomy by enabling open and informed dialogue throughout the bioeconomy innovation processes (b) build up and strengthen a bioeconomy community, (c) gain a common understanding of the concept, providing reliable insights into bioeconomies, its practices, benefits and implications (d) foster learning and education. With that, the project will support the reduction of existing barriers towards a bioeconomy and stimulate bioeconomy activities at the regional and EU level.


**Keywords:** bioeconomy, outreach, arts, public engagement, science education, formal education, RRI, co-creation, transdisciplinary research, interdisciplinary research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Fire-safe Sustainable Built Environment'.

assistant: **Innovation**

The FRISSBE project will implement new practices at the Slovenian National Building and Civil Engineering Institute, ZAG, by attracting and maintaining high quality human resources under the direction of the ERA Chair holder. The project will lead to lasting, sustainable structural changes to achieve excellence at ZAG and spread excellence in the region. Designed structural changes aim to achieve excellence in the field of fire-safe sustainable built environments, modify ZAG’s research and innovation landscape, intensify strong cooperation with industry and result in enhanced competitiveness in attaining projects. Changes will be tested in a new autonomous unit, the FRISSBE ERA Chair, and transferable to ZAG as a whole. Structural and dissemination measures are balanced with testing and improving the concept. Structural measures involve improving the workflow, focusing on project preparation and quality management, building a network with stakeholders, and intensifying cooperation with industry. The concept will be tested on a few levels: testing the research enhancement process, building capacity in applying for competitive funds, and building sustainable relationships with industry. Dissemination activities focusing on two-way cooperation with identified stakeholders will enhance ZAGs network and positively contribute to its attractiveness. FRISSBE will have regional impacts in terms of research, education, and engineering. The team will build a strong interactive ecosystem with the InnoRenew CoE and the University of Primorska, as well as other supporters of the project. Added value of the project is amplifying the capacities of the Fire laboratory co-financed with ERDF funds, ensuring conditions to foster excellent research. The project will yield 3 PhD students and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Multiscale Methods for Segregation Phenomena in Solid Oxide Fuel Cell Materials'.

assistant: **Innovation**

Solid Oxide Fuel Cell (SOFC) technology is expected to play a major role in future sustainable energy strategies. However, there are still major technological challenges concerning cell lifetime and systems costs, both of which need to be improved by factors 5 to 20. In view of the latter the goals of the project are to:1. improve the durability of SOFC stacks by supplying a broad understanding of degradation processes in steady-state and transient operation;2. understand the behavior of oxygen reduction and incorporation at the cathode and its link to segregation in order to achieve high power density SOFC cells; 3. guide the search and design of novel cathode materials and optimization of microstructures.During this proposal I wish to develop coupled atomistic-continuum framework in order to model SOFC cathodes. The framework couples concurrently continuum computations within materials bulk with Kinetic Monte Carlo method at interfaces between different phases and it has the speed of continuum computations and the accuracy of kinetic modeling. Since atomistic simulation of realistically sized cathodes will be possible, significant insights on the behavior of oxygen reduction, its link with segregation and time dependent degradation phenomena are expected. A key element of this proposal is the close interaction between modelers, experimentalists and industrial partners. The new insight will be used for computer-based optimization of cell efficiency and durability. This grant will employ a team leader, one PhD student, one part time advanced undergraduate and it will be integrated with classwork. The project will be partially funded (about 60%) by the U. Heidelberg.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Enzymatic synthesis of chiral drugs: cyclopirrolones and 1,4-dihydropyridines'.

assistant: **Innovation**

The scientific and technical objectives of this research proposal concern pharmaceutical registration of chiral drugs: (+)-zopiclone and 1,4-dihydropyridines. Although it's very well-known the influence of the drug stereochemistry in their activity, up to 1994 most of the chiral drugs are marketed as a racemic mixtures. The biological activity, bioavailability and metabolism of a drug can be very different for each one of the enantiomers of a chiral drug. The growth of the demand of chiral drugs has stimulated the research of new roads for the synthesis of pure enantiomers with therapeutical activity. We are still at the begining of a long way that may lead to the replacement of racemic drugs by the more selective and/or potent and/or safe single enantiomer. Research is required to synthetise the chiral drugs, studie the activity, bioavailability and selectivity of optically pure enantiomers . Also required the optimisation of experimental conditions of scaie-up process.