RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Malopolska Researchers' Night 2013'.

assistant: **Concept**

In 2013, Malopolska Researchers' Night will be organised for the seventh time. Malopolska Researchers’ Night 2013 will be organised on an unprecedented scale thanks to the involvement of 24 Partners (both consortium and non-consortium members) and 24 collaborating institutions. On 27 September 2013, all present and future lovers of science are invited to join researchers in the four regional towns and cities participating in the project, i.e. Krakow, Tarnow, Nowy Sacz and Niepolomice, and explore the secrets of the research profession or just have fun playing with science. A record number of ca. 700 researchers and ca. 500 students (a total of 1,300!) as well as over 60 students’ associations have offered to assist with the project. Apart from the Partners participating in previous years of the project, new institutions, faculties and departments have joined this year’s project. Attractions such as ca. 150 workshops, 180 shows and demonstrations, over 100 lectures and guided tours of nearly 60 laboratories will await those who visit one of the 42 locations participating in Malopolska Researchers' Night 2013. Lovers of puzzles will have a choice of ca. 35 competitions and quizzes and children will be invited to ca. 25 games with researchers. Malopolska Researchers' Night 2013 will offer an opportunity to demonstrate not only what researchers do at work but also what they do in their free time. There will be exhibitions, theatre plays featuring researchers as actors, meetings and discussions over a cup of coffee and a talk show with researchers. Given the wide and varied programme of attractions, the participation of new institutions and the lessons learned from the six previous years of the project (it attracted 46,000 people last year) it is estimated that over 55,000 p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A complex educational tool based on the power of music, dedicated to preparing children for the challenges of the future by supporting global educational and therapeutic systems.'.

assistant: **Objectives**

The aim of M company is to remove barriers in education and to prepare children from the earliest age for challenges of the future. The company achieves this by delivering a set of tools for holistic education that uses the most universal language – music. The innovative, globally awarded Musicon educational machine for kids and its accompanying methodology (Musicon BAND), is the first analogue programming tool that uses music. The project has been awarded in the largest world competitions both for design and educational approach. Musicon’s operation and effectiveness has been confirmed by thousands of children and educational institutions as part of a pilot program in Poland and abroad. Some of the project objectives are: level opportunities by providing solutions of educational and therapeutic tools that teach composing and programming without the use of screens; Provide tools for therapeutic work supporting psychomotor development in order to compensate for cognitive and socio-emotional deficits of children; Lift barriers in music education. It’s necessary to provide educational tools that teach holistically to prepare children for changes of the structure of future professions. The Council of EU agrees that “Education and training systems (...) have a fundamental role to play in developing creative and innovative capacities from an early age as key factors in enhancing future economic competitiveness and employability”. M Company is prepared to fulfill above ambitions and is prepared to do so thanks to the team with all required competitions and with a broad experience in product design and sustainable tech.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Conformation Of S-phase chroMOSomes' in the context of a Horizon 2020 call.

assistant: **Objectives**

DNA replication initiation is strictly regulated to ensure complete genome duplication. In eukaryotes, temporal control of origin firing across chromosomes establishes replication timing domains. Failures in the timing of replication initiation across chromosomes is implicated in DNA replication stress, a hallmark of cancer, but the function of these temporally restricted replication domains is not understood. As well as the duplication of DNA, S-phase involves the duplication of all chromosome structural elements and the complete separation of chromosomal intertwines. How this is achieved is poorly understood.A major hurdle for understanding how 3D chromosomal structures are duplicated in S-phase and inherited through mitosis is that current Hi-C methodologies do not give a distinction between chromatids during or immediately after DNA replication. This project aims to visualise the structure and interactions of replicating chromosomes by developing a new Hi-C method which will allow a separate analysis of each new sister chromatid during its formation. This will provide unique information about how DNA loops and interactions are replicated and resolved, preventing the accumulation of toxic chromosomal defects in each new daughter. This method will then be extended to address the impact of replication stress for the inheritance of chromosome structure. The project will result in a new understanding of the interplay of replication timing, DNA damage and chromosome structure, which may provide a novel framework to understand the causes of chromosomal aberrations that accompany tumour progression.


**Keywords:** Replication Origins, Hi-C, Replication Stress, TAD, A, B Compartments, Replication Timing Domain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Interacting with Active Particles' (InterActive).

assistant: **Concept**

Active particles refer to out-of-equilibrium self-propulsive objects such as biological microswimmers and engineered colloidal particles that can form various fascinating collective states. Active particles are easy to observe experimentally but notoriously difficult to interact with due to their fast and stochastic dynamics at both single-particle and collective state levels. In this project, I aim at scientific breakthrough in both instrumentation that allows direct interaction with active particles and using the methodology to progress substantially our understanding of dynamics and phase transitions of active particles.The first part focuses on rendering active particles, including E. coli, C. reinhardtii and Quincke rollers, permanently magnetized and designing suitable hardware for controlling them in real time. These particles are rendered “intelligent” by programming their behavior based on real-time image analysis (long-range vision) and steering with external magnetic field. I will program these particles to reveal the limits of using local dissipative hydrodynamic near-fields to guiding active particles, and demonstrate unambiguously the extent to which a single active particle within a collective state can control the collective behaviour.The second part aims at realizing tuneable magnetic traps and other conservative potential energy landscapes for non-magnetic active particles by using magnetophoresis in superparamagnetic fluids. I will use the technique to establishing confinement-activity phase diagrams for both biological (C. reinhardtii) and synthetic (Quincke rollers) active particles in quadratic confinements. I will further reveal the role of dimensionality (1D vs 2D vs 3D) in the phase transitions of active particles and carry out the seminal inves
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MILLIKELVIN VISUALISATION OF TOPOLOGICAL ORDER', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The urgent imperative to discover and understand topological quantum matter (TQM) is based both on the fundamental significance of its rich new physics and on the potential for unprecedented applications e.g. topological quantum computing. Specific topological ordered states, such as topological superconductors, ferromagnetic topological insulators, and topological Kondo insulators, are now the focus of physics research. Their microscopic quantum states have proven very difficult to address experimentally, one reason being the lack of instrumentation designed to deal with their novel measurement challenges, especially in high-resolution visualization of TQM.  However, new opportunities for this field, based on discovery of viable new materials and on the development of new visualization techniques, have emerged very recently. Therefore, we propose to develop and utilize a suite of new spectroscopic imaging scanning tunnelling microscope instruments capable of visualizing topological quantum matter at millikelvin temperatures. The objective is to achieve the extremely high energy-resolution required to access the energy gaps and exotic electronic states of TQM. Using these unique instruments, we propose a specific sequence of key experiments on direct visualization and quantitative understanding of topological quantum matter. These include direct measurement of the momentum-space structure of the energy gaps of topological superconductors, ferromagnetic topological insulators, and topological Kondo insulators. We plan atomic scale visualization of the Cooper-pair condensate, the ferromagnetic state, and the heavy-fermion hybridization to explore how the real-space structure of these ordered states influences their topological characteristics. Finally, we propose to visua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Control of photorespiration in plant leaves by rDNA technology: effects on plant physiology, agricultural productivity and water use efficiency' (1994-1998).

assistant: **Innovation**

The agricultural productivity of crop plants like wheat, barley, potatoes and sugar beet is limited, not only by growing conditions but also by the performance of the photosynthetic apparatus. This is because these crops assimilate CO2 by the C3 pathway of photosynthesis and are subject to the limitations of the processes of photorespiration which lead to a loss of a proportion of the newly assimilated CO2 through the decarboxylation of glycine. In contrast, crops, like maize, which use the C4 pathway of photosynthesis do not lose CO2 in photorespiration. Conventional genetic approaches have not succeeded in alleviating the negative aspects of photorespiration in C3 plants. However, species with intermediate forms (C3/C4) of photosynthesis exist which appear to have improved photosynthetic characteristics and water use efficiency. Studies of these have given some ideas as to possible genetic modifications which might improve C3 plants. For example, the distribution of glycine decarboxylase within the leaf is changed such that the amounts in the mesophyll are much reduced and the amounts around the vascular tissue increased. Now that the major C3 crops can be transformed, it is possible to try to introduce such genetic changes into them using rDNA techniques and see if they improve crop performance. The project has this aim which will be achieved by meeting the following measurable objectives: 1 Production of transgenic potato and wheat plants with less glycinede carboxylase in the mesophyll cells of leaves. 2 Production of transgenic potato and wheat plants with greater expression of glycine decarboxylase in cells surrounding the vascular tissues of the leaf. 3 Combine the reduced expression in the mesophyll with increased expression in the vascular tissue within the sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Parallel scalable computers for high performance' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project intends to develop a high-performance parallel processing system and associated tools which can function as a fully integrated component in an enterprise system.The consortium will build two application systems: one for control and one for information management. Emerging standards both in software and hardware will be exploited to investigate the design and implementation of fully featured CORBA-compliant software based on SCI and a multiprocessor operating system kernel. The work will determine the scalability of systems using a combination of shared-memory multi-processors, where medium CPU performance, high data transfer rate and low latency is required, and SCI-connected shared-memory multi-processors, where the CPU power and data bandwidth has to be increased by an order of magnitude. The goal is to define a software approach that produces portable and scalable software applicable to the above hardware configurations. It is intended to produce a hardware platform scalable from a few to several thousand processors. It is expected to use the system in the following applications: concurrent engineering, simulation, control systems, high-performance data warehouses and molecular databases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Carbonate chemistry, carbon cycle and climate change (a multidisciplinary view)' to be submitted under Fifth Framework.

assistant: **Abstract**

Boron isotope studies and box modelling lent strong support to the hypothesis that pore water driven calcite dissolution during glacial periods can account for a significant part of the observed G-IG change in atmospheric pCO2. We propose to test the validity of this scenario by combining a down core study with numerical modelling . So far , no one has used all available proxies on the same samples to reconstruct the ocean carbonate chemistry. Such a study will help to identify natural sources and sinks of CO2. Knowledge of the nature and amplitude of fluctuations in the past can be used to assess the potential range of variations in the present ocean. Present day pCO2 increase, acidifies the ocean and reduces the calcification capacity of oceanic carbonate producers, introducing a mechanism for pCO2 decrease. We propose to quantify this negative feedback.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Enhancing public awareness on the results of European research actions on Climate Friendly Transport Systems through the professional use of television media'.

assistant: **Objectives**

The strategic objective of GREENTRANSPORT-TV is TO CONTRIBUTE TO THE DEVELOPMENT OF PUBLIC AWARENESS ON THE EUROPEAN RESEARCH ON GREENING TRANSPORT IN ALL EUROPEAN COUNTRIES THROUGH THE PROFESSIONAL USE OF TELEVISION MEDIA. This objective will be achieved through the exploitation and the customisation of an acknowledged innovative TV media communication model, already successfully implemented by the GREENTRANSPORT-TV partnership over the past 5 years. In particular, GREENTRANSPORT-TV will: • Highlight the key results from the Greening Transport research in FP6 and FP7. This will be done through ongoing consultation with the relevant stakeholders and in-depth research into individual RTD projects, identified by these stakeholders as being of particular interest and relevance. The project will leverage on the success of the DG TREN project ENERGY-TV (2007-2008), delivering 12 videos on the European research on green energy systems (including biofuels) to the European TV media. • Create a series of 12 high-quality free-of-rights Video News Releases (VNRs) for the general public on the basis of the key results of the research. The audiovisuals will be conceived in such a way to be easily adaptable to the needs of a wide spectrum of European TV channels, either for news or features usage. • Include all 12 released VNRs into the broadcasting mainstream of the European TV stations by implementing a consolidated communication model involving the totality of the national European TV media. • Establish a sound science-based dialogue on Greening Transport issues by introducing all released VNRs and the associated written materials (articles, press releases, etc.) into a series of highly references internet platforms. • Monitor the results of the project and assess its achievements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Impact of soil microbiodiversity on the development of wild mammal gut biota and immune function'.

assistant: **Objectives**

The biodiversity hypothesis asserts there is a link between the diversity of environmental and host-associated microbes and civilization diseases', such as asthma and allergies, the result of immune dysfunction and chronic inflammation. Using a well-studied rodent model, the bank vole, SOIL2GUT will test for the first time whether exposure to natural communities of soil microbes during development can improve individual health by promoting microbiota function at the host-microbiota interface (ileum and colon mucous layers) and reduce the risk of immune-related diseases. SOIL2GUT will take advantage of tissue samples generated by an ongoing intervention experiment, promoting the 3Rs policy, but also providing a unique opportunity for omics integration (metataxonomics + MTX). Innovatively, this project will focus on the function of gut flora (not merely taxonomical characterization), in both bacteria and fungi (the latter is particularly unusual), using recent developments in metatranscriptonomics (MTX) to explore functional activity, and combining metadata and metatranscriptomes in statistical models to identify critical factors determining health. Since 68% of the human population will be urbanized by 2050, SOIL2GUT will contribute significantly to the WHO OneHealth framework. This project will also provide data that can be used to plan urban greenspaces, enhance rewilding interventions and improve domestic and zoo animal wellbeing. The researcher will build on his previous experiences and solid publications as a PhD/postdoc, receiving advanced personalized training in bioinformatics and soft skills, including writing grant applications for expanding to other tissues (lung, skin), and rendering him highly employable. In exchange, the researcher will bring methods for me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Expression system for production of chiral hydroxy-compounds by whole cell biotransformation and in -situ extraction with a continuous high-cell-density recycling bioreactor system(BIOTRANS)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The aim of the project is the development of a new recombinant expression system for an Escherichia coil based cell factory which is favourable for whole cell bio transformations in a continuous fermentation process with an in site two-phase extraction system for the organic stereo-specific product.