RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Refugees and Revolution in the Atlantic World, 1770s-1820s'.

assistant: **Innovation**

This project explores movements and networks of refugees and exiles of the revolutions in the Americas and Europe (1770s–1820s). Political modernity, brought about by the “age of revolutions” and often identified with new notions of sovereignty and citizenship, was intertwined with the emergence of the political refugee as a mass phenomenon. Unprecedented numbers of people—in total, well over a quarter million—sought refuge in countries other than their own on primarily political, rather than religious, grounds. The project sets out to show that political migrants and refugee movements were at the very core of major transformations that the Atlantic world underwent during these momentous decades. These include the reshaping of citizenship and subjecthood regimes, changing practices of welfare and early humanitarianism, the porous and shifting boundaries between freedom and slavery, and the emergence of transnational exile politics.While there is growing consensus that revolutionary ideas and actors in the Atlantic basin can no longer be studied in isolation, those who opposed and fled these revolutions have received strikingly less attention. Focusing on the interactions between refugees and receiving societies in a variety of contexts, Atlantic Exiles breaks new ground on two interlocking levels of inquiry: It recasts the Caribbean as one of the world’s major receiving and transit region for refugees during this period and it provides the first systematic exploration of exile and refugee movements in a decidedly Atlantic perspective. In addition, it sets the findings from the Atlantic world into a long-term and global history context. Based on multi-site and multi-linguistic research and the close engagement with records in the Caribbean, the project opens up new avenu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Accessibility and structure conservation at hepatitis c virus rna target motives to human rnasep' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The host laboratory has recently discovered that human RNaseP specifically cleaves the hepatitis C virus RNA in vitro. We will assess whether RNaseP plays any role in the virus life cycle and whether such cleavage may be postulated as a therapeutic target.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Insights into the role of phages on the bacterial resistome' (ROPHARE).

assistant: **Concept**

There is an imperative need to gain knowledge on the spread and evolution of antimicrobial resistance (AMR). Recent evidence from environmental, animal and human microbial studies shows that AMR is ancient and environments without contact with anthropogenic antibiotics possess abundant AMR genes. Bacteriophages are the most abundant entities in Earth and recent studies provide indirect evidence for the major role of transduction in the dissemination of AMR genes. Hence, phages might be of critical importance for evading one of the bottlenecks (ecological connectivity) that modulates the transmission of AMR genes from natural environments to animal and human biomes. In this proposal, a holistic and multidisciplinary approach that combines molecular genetics, genomics, metagenomics, in-vitro experimental analysis, computational biology, bioinformatics analysis, and modelling will be followed to measure the potential of naturally occurring phages to be vehicles for AMR transmission and spread in environmental systems with different antibiotic selective pressure. This comprehensive approach will allow us to better understand the phage-bacteria interactions that drive the AMR spread in different ecosystems. From this understanding we expect to be able to design and develop new tools for the control of antimicrobial resistance in clinical and veterinary practice as well as in agriculture. This project will contribute to the objectives of the Work Programme by: 1) allowing the researcher to gain new skills and additional training-through-research in phage and phage-bacteria interactions, computational and (meta)genomic analysis; and to become an EU leading specialist in a research field with emerging growth potential; 2) transferring the acquired knowledge to the EU; 3) establ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EUROPEAN SYNCHROTRON RESEARCH AT BESSY' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The 'Berliner Elektronenspeicherring-Gesellschaft fur Synchrotronstrahlung mbH' (BESSY GmbH) is a non-profit making company, which operates the only dedicated high brightness source of synchrotron radiation (SR) in the vacuum-ultraviolet (VUV) and soft x-ray (XUV) regions of the spectrum (photon energy region -5 eV to -2 keV) in Germany. The service-oriented facility BESSY I has been in operation since 1982 and has offered routinely more than 3000 hours of SR/year for its users since 1991. The main areas of activity have been basic and applied research in several scientific disciplines as well as metrology and x-ray lithography for industrial applications. For running the well-established SR facility BESSY I the BESSY GmbH employs 76 staff members and has an annual turn over of ca. 8 MECU. In addition a new high-brilliance third generation SR light source, BESSY II, will go into operation at the beginning of 1998. With the present proposal BESSY intends to make SR readily available to the interested outstanding scientists in Europe, particularly those in peripheral countries of the European Community, who do not have national SR centers. What we propose is essentially a continuation of the current EC-HCM/LSI programme, which is considered by our users as a means to innovative and demanding science towards the technological challenges of the next century. EC researchers have access to 35 specialized measuring stations. including 2 x-ray microscopes, which are connected to various types of monochromators. A subtotal of 11 experimental stations is readily available for EC researchers. Typically, these stations are equipped with electron spectrometers and/or various types of electron and photon detectors and the necessary equipment for sample preparation, characterization a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High-Field Magic-Angle Spinning Electron Paramagnetic Resonance' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Dynamic Nuclear Polarization (DNP) is the most widely applicable method for solving the main problem of nuclear magnetic resonance (NMR): its low sensitivity. This is achieved by polarization transfer from electron spins to nuclear ones, allowing for up to two orders of magnitude signal enhancement, which enabled the expansion of NMR to multiple systems previously unamenable to it. Despite two decades of extensive research, DNP is yet to reach its full potential, the bottleneck being the quantum-mechanical understanding. While Electron Paramagnetic Resonance (EPR) experiments have provided multiple insights on static DNP mechanisms, leading to improved DNP experiments, analogous EPR experiments for Magic Angle Spinning (MAS)-DNP, the most prolific DNP variant, were never performed. Instead, our understanding of MAS-DNP relies on theoretical considerations and numerical simulations, which naturally cannot capture the entire picture. The main obstacle for MAS-EPR is the complexity of the instrumentation and lack of methodology to perform EPR experiments under characteristic MAS-DNP conditions: high magnetic fields, cryogenic temperatures, and MAS. This project aims to bridge this crucial gap. We have recently recorded the first high-field MAS-EPR spectra, using a unique high-field dual DNP/EPR spectrometer specifically tailored to the investigation of DNP mechanisms, designed and constructed in my lab. In this project, we will expand the experimental capabilities by developing the dedicated hardware and establishing the methodology for high-field, cryogenic MAS-EPR. This will allow, for the first time, to experimentally observe the electron spin dynamics in MAS-DNP, thus deciphering the DNP mechanisms. This will  unlock the full potential of MAS-DNP, allowing for systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Neutrino-2002' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Undoubtedly, Neutrino Physics, including Neutrino Astrophysics, currently is among the most active and rapidly evolving disciplines in fundamental physics, with major new discoveries having been made in recent years. The International Conference on Neutrino Physics and Astrophysics", which is conducted every two years at varying places in Europe, North America, and Asia, is the most prestigious international conference in this field, with the majority of the experimental discoveries and progress in theory having been announced for the first time at the Neutrino Conferences. Max-Planck-Institute für Physik, Munich, and Technische Universität München have been selected among strong international competitors to jointly organise and host Neutrino-2002, the twentieth conference in this series. The scope of the conference is to provide an international forum for the presentation and discussion of recent developments in Neutrino Physics and Neutrino Astrophysics. Neutrino-2002 intends to bring together the internationally leading experts of the field and the best young researchers, to discuss new results and developments, exchange ideas and new insights, stimulate promising future research projects and promote both existing and new collaborations.The scientific program of the conference covers essentially all sub-disciplines of Neutrino Physics and Neutrino Astrophysics, as well as relevant topics from neighbouring fields, e.g. astrophysics. This includes, among others, neutrino physics at particle accelerators and nuclear reactors, solar and atmospheric neutrinos, neutrino oscillation searches, neutrino telescopes, investigation of fundamental neutrino properties, relevance of neutrinos for cosmology, dark matter, and astrophysical aspects of neutrinos (e.g. supernovae, cosmi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Robust Lightweight Cardan Shaft' (RLICS), addressing dissemination and exploitation.

assistant: **Impact**

Josef Hohn GmbH has longstanding experience as an original equipment manufacturer (OEM) for commercial vehicles including construction machines and agricultural machines and provides innovative and high-quality products to satisfy customers’ needs. Particularly cardan shafts which are part of the power train of automobiles are in the core of Hohn’s expertise. Environmental regulations controlling the vehicles’ emission of CO2 and air pollutants as well as the need to increase the vehicle’s payload have forced commercial vehicle manufacturers to explore new technologies, in particular lightweight construction. However, previous lightweight cardan shafts technologies for commercial vehicle  were not ready for market due to either high costs or safety problems. RLICS, the innovation described in this proposal, is a radically new approach to constructing cardan shafts. Due to the innovative design as well as a result of simplifying the fabrication, the new product is approx. 30 % lighter than conventional cardan shafts, has an increased life time even under higher loads and can be produced at a cost of approximately 20 % below conventional fabrication costs. With RLICS, Hohn envisages to create a unique selling proposition for significantly increasing its market share in the segment of construction vehicles and agricultural machines and, for the first time, for entering the market segment of small trucks and buses (<7.5 tons). To unlock the exceptional market potential, activities to prepare commercialisation of RLICS are to assess suitable markets, increase customer involvement, validate the technological viability and finally to contrive a detailed business plan. Granted successful commercialisation, we expect a cumulative turnover of 45 million € related to RLICS and an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Single molecule sequencing and biophysical properties of oxidized genomic DNA using magnetic tweezers.' (EpiSeq), addressing dissemination and exploitation.

assistant: **Impact**

Next-generation DNA sequencing technologies are at the core of modern molecular biology and are rapidly entering the technological arsenal for personalized medicine. The recent explosion of sequencing technologies has provided researchers with various solutions to fit their sequencing needs, with a large spectrum of costs and limitations. However, most sequencing methods use enzymatic duplication of DNA to generate a strong enough sequencing signal. Therefore, chemical modifications potentially present on native bases are lost, and with them, an entire level of epigenetic information about. Although some workarounds are emerging, they are indirect, costly, and not yet amenable for the targeted sequencing of a given native genomic locus or biophysical analysis of the modified DNA. Given the need to understand the epigenetic layer of genetic information, I propose to develop a reliable and cheap method to map, at the single-molecule resolution, the epigenetic status of a genomic DNA locus of interest. This will be achieved through biochemical capture of this locus using CRISPR/Cas9 technology, and its epigenetic sequencing via single-molecule manipulation by magnetic tweezers. In addition to identifying the nature and the position of the modified bases at a given genomic DNA locus, I will use this magnetic tweezer technology to address fundamental questions about the effect of epigenetic modifications on the biophysical properties of DNA (formation of DNA structures and protein interactions). Specifically, I will focus on 8-oxoguanine, for which there is increasing interest since it is a hallmark of degenerative pathologies like cancer or Alzheimer’s Disease, and since it has recently entered the known epigenetic arsenal. This project has great potential applications in m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Living longer in poorer health? Understanding the immigrant morbidity-mortality paradox' in the context of a Horizon Europe call.

assistant: **Objectives**

If the global foreign-born population all lived in single country, it would be the fifth largest country in the world. The rapid rise and diversification of contemporary worldwide migration has no precedent in history. There is clear evidence that immigrants are healthier than native-born populations are. Although this health advantage is pervasive for mortality (i.e., death), it is regularly absent, or even reversed, for morbidity (i.e., diseases and medical conditions). This is alarming because it suggests that migrants are living long lives in poor overall health. With immigrants ageing in place, this should constitute one of the most highly relevant social and public health concerns today. Yet, beyond evidence from disparate data sources of variable quality and coverage, there is a distinct absence of direct, coherent, empirical knowledge of this morbidity-mortality paradox.To address this gap, I aim to establish the existence, extent, and causes of this immigrant morbidity-mortality paradox. I will use cutting-edge techniques to analyse longitudinal micro-level data on morbidity and mortality from the same source of information: the population registers of Denmark, Finland, Norway and Sweden.Work Package A will reveal how prevalent an immigrant morbidity-mortality paradox is within the Nordic region and evaluate the role that this paradox plays in our understanding of wider population health. Work Package B will identify the intricate disease spectrum, causes-of-death, and granular immigrant origins essential to understanding the paradox. Work Package C will identify the mechanisms that can explain the paradox. This research has the potential to (1) transform the limited way in which the health of immigrants is currently conceptualised and understood, (2) revolutio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Standardised metrology of Nano-sTrUctuRed CoAtings with Low surface energy'.

assistant: **Objectives**

There is a growing range of applications that would benefit from the use of nanostructured coatings. The functional performance of a surface is intimately linked with its structure. The ability to characterise nanostructured coatings is therefore an essential part of their future uptake. However, the ability to examine and characterise at the nano-scale is currently limited to sophisticated, time-consuming laboratory based equipment.The standards body (ISO TC229) recognises that there are no current procedures that relate the functional performance of a surface or coating to its nanostructure, however, it is recognised that loss of the nanostructure frequently leads to a loss of performance.The NATURAL project will develop methods that allow rapid evaluation of surfaces at the nanoscale and correlate the measured surface structure with functional performance. This step change in measurement methodology will enable new lifetime determination methods and enhance the knowledge base for providers of nanostructured coatings and surfaces to tailor their products and technologies towards the end-user needs. This will facilitate the entrance into the market place of novel nanostructured coatings with proven capability to improve properties such as fouling resistance. In order to achieve this, NATURAL will focus on the development of surface profilometry methods to allow the rapid resolution of surfaces at the nanoscale. These methods will be correlated with the physical and physico-chemical characteristics of surfaces to allow their rapid, reliable and accurate assessment. The change of the surface nano-morphology and the functional performance will be related to allow the estimation of durability and to enable the development of new methods for lifetime determination and, ulti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CellPrintArray – on-demand nano-scale printing of live cells and compounds for miniaturized cell screening applications' (CellPrintArray).

assistant: **Innovation**

The goal of this ERC-PoC project is to develop a prototype system that will enable the addition of libraries of drugs and biochemical molecules, reagents and cells from a 96 source plate directly to individual compartments of the target Droplet Microarray (DMA). The system should have controlled atmosphere (CO2, humidity, temperature) and should allow for dispensing controlled volumes (3-500 nL per experiment) and cell numbers (1-100 per experiment) into individual droplets. We aim to create and evaluate this system for applications commonly performed in pharmaceutical companies and screening centers to enable them to perform miniaturized and more predictive high throughput screenings using physiologically relevant cells such as primary cells, stem cells, biopsy-derived cells and other scarce cell types. The system should allow high-throughput screenings with patient derived cells and therefore will open new possibilities in drug discovery and personalized medicine.