RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Biodiversity of methylotrophs and their remediation and biotechnological exploitation'.

assistant: **Objectives**

Metamorphic bacteria can grow in large scale on cheap substrates such as methane and methanol, and contain unique metabolically versatile enzymes offering enormous potential for clean biotechnology. Organisms currently in culture are not robust/versatile enough to clean up organic pollution in bioremediation processes or for the production of fine chemicals. We propose to examine the biodiversity ofrnethanotrophs in extreme/unexplored environments, using conventional and state of the art molecular ecology techniques to isolate/characterise novel psychrophilic, thermotolerant, acidophilus, alkalophilic, salt and solvent resistantmethanotrophs containing catalytically versatile methane monooxygenase creating portfolio of bacteria for exploitation in bioremediation, and biotransformationprocesses. We will also modify methanotrophs by mutation and metabolic engineering of methane monooxygenase to create new versatile biological catalysts.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'European Consortium on Synaptic Protein Networks in Neurological and Psychiatric Diseases'.

assistant: **Objectives**

Signalling at nerve cell synapses - a key determinant of all aspects of brain function - depends on the function of hundreds of synaptic proteins and their interactions. Numerous recent studies showed that a wide range of neurological and psychiatric diseases are 'synaptopathies' whose onset and progression are due to mutations of synaptic proteins and subsequent synaptic dysfunctions. EUROSPIN will pursue a multilevel systems biology approach to determine mechanistic relationships between mutations of synaptic proteins and neurological and psychiatric diseases, and to develop new diagnostic tools and therapies. Our concept is based on the current knowledge of disease genes, which we will continuously extend with new human genetic data and complement with large-scale screens of mutant mice in order to identify and characterize disease-relevant mutations in synaptic proteins and corresponding mouse models. Proteomic tools will be used to analyse the protein components of synapses, and protein interaction networks of synaptic disease gene products will be mapped systematically. In parallel, smart libraries will be employed to develop small molecules for perturbing the functions and interactions of disease gene products. Functional models of disease-relevant protein networks will be generated and used to formulate hypotheses as to how specific mutations might affect synaptic physiology and network function, and thus cause disease. These hypotheses will initially be tested in reduced systems by novel physiological and imaging methods. Well-validated disease gene products, the consequences of their dysfunction in disease, and therapeutic modifications of their dysfunction will then be studied in mouse models in vivo, applying novel electrophysiological, imaging, and behaviou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Focused high throughput structure function analysis of human proteins involved into programmed cell death and inflammation' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Programmed cell death and inflammation are two closely related, fundamental processes in eukaryotic cells. Defects in either process or in the signalling cascades leading to these processes have severe consequences including major diseases like cancer and au toimmune diseases. Here we want to investigate the biochemical and structural properties of human proteins involved in PCD and inflammation by state of the art high throughput means.The key to any biochemical and structural analysis of a protein is the ability to express and purify the protein of interest. Methods adopted from structural genomics initiatives provide today the opportunity to investigate many constructs of proteins in parallel or entire protein families in a high throughput manner. As investigated system we have chosen the RIP kinase family and complexes, in which RIP kinases play a role. Recent results show that the RIP kinase are involved in key steps in PCD and inflammation and are therefore important regulatory proteins. They seem to have also higher affinities to several important small molecule kinase inhibitors, than the actual targets, e.g. Abelson or p38 kinase.RIP kinases are known to form complexes using their N- or C-terminal protein-protein interaction domains to target the ki nase domains to their site of action. Furthermore, the heat shock protein 90 (HSP90) is believed to interact with the kinase domain of the RIP kinase family, similar to the cyclin in the cyclin dependent kinase super-family. Other targets enclose members of the Caterpiller superfamily of proteins. The Caterpiller proteins are multi-domain proteins with a highly homologous molecular architecture, comprising an N-terminal protein-protein interaction, followed by a NTP dependent oligomerisation domain, a C-term inal de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Public technology procurement as a strategic innovation policy mix instrument' (OMC-PTP).

assistant: **Concept**

The OMC-PTP initiative will be a network of policy actors aiming at the exchange and learning on public technology procurement procedures (PTP) and their implementations. PTP is considered by the OMC Expert group on policy measures to be the most powerful tool in the array of policy instruments needed to achieve the Lisbon 3 % target. However, most countries are struggling with the implementation of PTP in the context of the procurement directive 2004/18/EC. Case IV of the OMC/SME expert group has delivered the state-of-the art on PTP in different Member States.A recent EU report provides a number of important recommendations, of at which at least a number will be addressed in this project, such as:- Conduct a review of current procurement practices against the best practices;- Member States, as part of their efforts to benchmark progress towards the 3&D investment target, should seek to develop indices of innovation in public policy supply markets;- Survey the use of IPR clauses in public contracts, and the impact on public and commercial exploitation of intellectual property developed in these contracts.The report concludes that _a major opportunity exists for Europe to advance its highest priority policy goals, and achieve the twin objectives of an R&D driven innovative and competitive economy on the one hand and first class public services for its citizens on the other. However, to realize this opportunity requires both high-level political commitment and detailed changes of practice within the procurement community and those who work with them.Therefore we aim to:- establish a network of relevant innovation policy actors- continue exchange of experience- develop common methodologies (toolbox/manual)- achieve alignment/coordination of relevant policiesDuring this ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Leaders Activating Research Networks: Implementing the LERU Research Data Roadmap and Toolkit' (LEARN) targeting Horizon 2020.

assistant: **Abstract**

We live in the age of the ‘data deluge’, where digital technology enables us to store petabytes of data and to make that available for sharing as open data. Sharing data has the potential to revolutionise the way that researchers work. It avoids costly duplication in the collecting of data and enables research collaborations across the world which otherwise would not be possible.The purpose of this bid is to take the LERU Roadmap for Research Data produced by the League of European Research Universities (LERU) and to develop this in order to build a coordinated e-infrastructure across Europe and beyond. LEARN will deliver a model research Research Data Management (RDM) policy, a Toolkit to support implementation, and an Executive Briefing in five core languages so as to ensure wide outreach.  LEARN will hold a series of Workshops within four European countries and one international country. The workshops will serve to advocate the Recommendations on RDM and open data made by the LERU Roadmap, and gain feedback from Workshop attendees for a new Toolkit of best practice. Furthermore, guidance to implement the Roadmap will be provided following identification of Best Practices supported by case studies identified through the workshops. By producing an exemplar RDM policy, which could then be tailored by any university or research institution to meet their needs, LEARN aims to address the challenges of the Work Programme concerning the fragmentation of e-infrastructures and the need to maximize on global research data. Specifically, LEARN will address Stakeholder initiatives; Policy coordination; Take-up of digital infrastructures; and Support cooperation with developing countries. LEARN thus delivers support actions to quicken the take-up of RDM and the move to open data i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unravelling the Nitrogen Fixation-Primary Production Feedback Loop: Implications for Carbon Cycling and Oceanic Health' (NIPROFEED) targeting Horizon Europe.

assistant: **Abstract**

The project ‘NIPROFEED’ delves into the vital interplay between primary producers, nitrogen fixation, and particle dynamics in aquatic ecosystems. Primary producers play a crucial role in capturing roughly one third of excess carbon dioxide and converting it into organic particles, central to the ocean's biological pump. This process, however, contributes to oxygen depletion as sinking particles lead to organic matter respiration and subsequent deoxygenation of bottom waters. Diazotrophs, specialised microbes capable of nitrogen fixation, provide a significant portion of nitrogen input into oceans, supporting primary production. NIPROFEED introduces the hypothesis that diazotrophs supplying nitrogen to primary producers can amplify particle formation, initiating a positive feedback loop that impacts carbon export and oxygen levels. To explore this feedback loop, NIPROFEED will employ cutting-edge techniques, including high-throughput sequencing, single-cell rate measurements and biogeochemical modelling. This will unravel the composition and functional role of free-living and particle-bound diazotrophs, shedding light on their contribution to nitrogen/carbon fixation. By implementing these parameters into an integrated model  the intricate relationship between nitrogen fixation and primary productivity will be investigated. Addressing this hypothesis, NIPROFEED aspires not only contribute significantly to scientific advancements in the field of marine science but also aligns with EU sustainability goals by shedding light on climate change impacts on our ocean.


**Keywords:** Nitrogen fixation, diazotrophs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Solar Hybrid Air-sCO2 Power Plants' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

SHARP-sCO2 aims to put the basis to develop a new generation of high efficient and flexible CSP plants.  Keeping on working on CSP-sCO2 power cycles and exploiting air as operating fluids also developing novel enabling technologies (receiver, storage etc.), SHARP-sCO2 will attain high working temperatures, guaranteeing reliable and flexible operation, optimal working conditions and high efficiency for the coupling of CSP with sCO2 power cycle thanks to the development of high performant sCO2-air heat exchanger. Leveraging on a smart and integrated hybridization with PV, enabled by the development of an innovative electric heater, SHARP-sCO2 will maximize the production, exploiting PV affordability while counting on the unique energy storage capabilities of CSP plants via thermal media. The latter will be also optimized by developing an innovative high temperature thermal energy storage. SHARP-sCO2, by means of a material selection process driven by environmental and economic criteria and aimed at maximizing the circularity of the solution, will lead also to lower LCOE/CAPEX for future CSP. Developing and validating in EU top level laboratories (IME, KTH, TUD) key cycle components (receiver, storage, HEXs, electric heater) SHARP-sCO2 will prove the effectiveness and techno-economic viability of air-driven/sCO2 CSP cycles. Four prototypes will be investigated in a cross-fertilizing lab campaign (TRL5) also to validate partners’ modeling approach to robustly study cycle integration (via a ”cyber-physical approach”). Taking into account EU/extra-EU solar irradiation, electric market perspectives, environmental, safety/regulation aspects too, the project, which involves EU R&D leaders in CSP sector, will be the first keystone towards the promotion of air-driven/sCO2 cycles a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel Therapeutic Strategies for Tissue Engineering of Bone and Cartilage Using Second Generation Biomimetic Scaffolds' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The main aim of the proposed network of excellence (Noël) is to combat and overcome fragmentation of European Research on the field of Tissue Engineering of Bone and Cartilage. The network will bring together Europe's leading academic centres and several complementary industrial players in a multi-disciplinary consortium to conduct and structure research that is able to compete in the internationally arena, namely with USA and Japan. The constitution of this network of excellence will lead to a complete restructuring and reshaping of the European research in this field. The size of the network (20 partners from 13 countries, including 9 of the EU member states), and the selection of its original members, was designed in order to join together the critical mass and all the expertises needed to be an unavoidable world reference on the topic of tissue engineering of bone and cartilage. In order to achieve that, the network also incorporates, as part of an International Advisory Board (not funded by EU), academic (but not industrial) partners of leading institutions in the USA, Canada and Singapore. These partners, leaded in most cases by researchers of EU nationality, agreed to join the network bringing in a specific expertise that will help to move European research on that particular topic. This Noël aims to provide new tissue engineering technologies for therapeutic treatments, which will ultimately have a major social impact by contributing to the challenge of providing lifelong health for our society at an affordable cost.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Transnational histories of 'corruption' in Central-South-East Europe (1750-1850)'.

assistant: **Objectives**

Politicians, scholars, and popular writers between 1750 and 1850 routinely characterized South-East-Central Europe as a corrupt political space. A wide range of foreign observers portrayed graft, nepotism, and bribery as endemic. Indigenous critics echoed many of these assessments. Regional insiders and outsiders alike mobilized commentaries on “corruption” for their own political, professional, and personal ends, claiming they could run more honest and efficient administrations, military regimes, and commercial operations than those in power. These notables linked “corruption” to the region's supposed cultural backwardness and economic under-development. In doing so, public figures naturalized notions of “corruption,” making it appear both widespread and organic in the region—popularizing tropes that have endured right down to the present. Yet, “corruption” is a historically specific concept. TransCorr seeks to construct a history of the idea of “corruption” in Central-South-East Europe in conjunction with the rise of modernity. It demonstrates how in the context of new ideas about modernity emanating from West Europe, regional leaders reframed a host of traditional customs and practices as corrupt. It examines how Great Power attempts to transform these borderlands into formal and informal imperial provinces further entrenched novel understandings of “corruption”, often pejoratively associating them with the Ottoman legacy. By tracing out this history, TransCorr reveals a genealogy of ideas, discourses, and attitudes that continue to inform analyses of and discussions within the region today. The project brings the study of this geographic area into greater dialogue with a global story of modernization and aligns the region’s historiography with new innovations in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Co-creating safer Living Roads for all through a holistic, multi-level, participatory approach to cultural transformation' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Roads4All orchestrates a transformative shift in traffic safety culture across Europe through a holistic, multi-level approach targeting individual, organisational, and institutional levels. Conceptualising Living Roads, we co-design, implement and evaluate a comprehensive and tailored set of real-world, theory-informed, context-specific, and culture-sensitive road safety interventions in 5 diverse settings. Our approach centres on continuous engagement with all key stakeholders, ranging from school communities and road users to enterprises and authorities, establishing continuous consultation, collaboration, and feedback. Drawing on evidence-based tools we develop, such as the Roads4All model, framework and decision support toolkit, our interventions leverage both theoretical and empirical insights. We drive change to influence attitudes and promote safe behaviours by innovating with open schooling and Cultural & Creative Arts and experimenting with advanced technologies. We educate, increase awareness building readiness for change, cultivate empathy and co-existence on road, and recommend safe organisational practices. Ultimately, we create guidelines, a roadmap for change and suggest policies towards institutionalisation of traffic safety culture. By integrating strategy and practice, we seek to develop essential values and norms that support a robust traffic safety culture. With a special emphasis on youth, we aim to address high-risk groups and promote long-term behavioural change. Our diverse consortium, consisting of 14 partners from 8 countries, and our consultation structures at national, EU and international levels, bring together a wide range of expertise across EU and beyond, ensuring the replication and sustainability of Roads4All results in various cultura
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sistema de marcación de jamones y utilización de eqiquetas electrónicas para la trazabilidad', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

We wish to implement specific tags where the identification Number of the tag would be duplicated four- times (one per ham of the same animal ) in an OTP (one time programming) technology, i.e. the origin of the four ham would be certified with the animal of origin. On the other hand, the electronic tag would benefit: from a Read/Write section of a few registers. where the producer would be authorised to read and write different information according to the process followed by each individual ham. Innovative also would be our information software that we would place on a handheld PC, operating under a shared system (possibly Windows CE or pocket PC) so that the information is directly available near the animal, and without the recourse of slow and costly remote databases.