RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MINImising Carbon footprint in maritime sHIPping' (MINI-CHIP) targeting Seventh Framework.

assistant: **Abstract**

Sea transport is a vital component of the world’s economy as the largest carrier of freight around the globe. Marine shipping is responsible for about 3.3% of the global greenhouse gas (GHG) emissions. International Maritime Organization in 2009 has set the target for 15% reduction in the maritime emissions by 2018. This requirement calls for further research into minimising carbon footprint of marine shipping through collaboration between industry and academia. The MINI-CHIP project aims to respond to this call in a timely manner. Earlier research on reducing carbon footprint of marine shipping has regarded GHG emissions as an implicit objective surrogated by fuel consumption and cost which could be combined with other items (such as penalty charges). It would be more illuminating for shipping companies to analyse trade-offs in the operational decisions including energy consumption and GHG emissions as explicit decision criteria. Such approach will support informed decision making through assessing the environmental impact of the operational decisions in maritime transport. To the best of our knowledge, no prior research has addressed minimising carbon footprint of marine shipping as an explicit objective alongside service level and cost objectives in a stochastic environment. MINI-CHIP project aims to address this gap by developing mathematical formulations of marine shipping operations as a stochastic optimisation problem to minimise carbon footprint whilst optimising service level and cost. Novel metaheuristic search techniques and simulation models will be developed within a simulation-optimisation framework. The innovative solution techniques will form the core of a decision support tool for industrial applications. The prospective decision support tool will help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Origin and Function of Tumor-Associated Macrophages and Mesenchymal Stromal Cells in GBM Subtypes'.

assistant: **Objectives**

One of the key goals to understand GBM biology and find strategies to treat this deadly tumor is to define the different cell populations within the tumor. The inter-tumor heterogeneity among GBM patients, investigated on a molecular level, has led to the identification of three main subtypes; the proneural (PN), mesenchymal (MES), and classical (CL), which are associated with specific mutations. The different properties of the three subgroups play an important role in the clinical response and the pathology of the tumor. The tumor microenvironment, that play an important role in tumor heterogeneity, is built up by multiple factors including recruited cells, blood vessels, secreted cytokines, and extracellular matrix. However, the constitution of these factors in each subtype is not known. In this work, we will characterize the cells that are recruited to the different GBM subtypes focusing on tumor-associated macrophages (TAMs) and mesenchymal stromal cells (MSCs). For this purpose, transgenic mice representing the three glioma subtypes will be used. Chimeric mice will be utilized to investigate the origin of the recruited cells. Flow cytometry, confocal analysis, multiplex assays and single-cell gene expression analysis will be used to characterize the tumor cells and the recruited cells to find master regulatory elements of recruitment. Therapeutic targeting will follow identification of master regulatory factors that recruit TAMs and MSCs to the tumor.


**Keywords:** Glioblastoma, GBM,  Tumor stroma,  microenvironment,  tumor-associated macrophages, TAM,  mesenchymal stromal cells, MSCs,  Tumor subtypes,  proneural,  mesenchymal,  classical,  genetic mouse, models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'SpatioTemporal Diversification of Enteric Nervous system' in the context of a Horizon Europe call.

assistant: **Objectives**

The enteric nervous system (ENS) contains an extensive range of neural subtypes that collectively control essential gut functions largely independent of the central nervous system (CNS). Enteric neuronal diversity is critical for maintaining normal gut function, and a selective dysfunction or local neuronal loss leads to gastrointestinal (GI) disorders. As current treatments of ENS-related disorders are suboptimal, development of novel regenerative approaches has the potential to significantly improve GI health for millions worldwide. As a first milestone towards cell-based regenerative therapies, the Marklund lab recently established a molecular classification of intestinal enteric neurons and discovered that they diversify through a conceptually new stepwise principle during development. The proposed project, DeSTENy, will significantly expand on these discoveries, and investigate how time and spatial context of developing GI tract controls the developing ENS to acquire the appropriate neuron identities at the right time and region within the mouse gut. DeSTENy will integrate cutting-edge regular and spatial single-cell transcriptomics to identify potentially important spatiotemporal driver genes in the ENS of the intestine versus stomach and oesophagus (upper GI-tract). While studies of the developing ENS has been challenged by its inaccessible location within the gut wall, DeSTENy will overcome this limitation by the utilization a precise, rapid and large-scale gene manipulation strategy based on ultrasound-guided transduction of ENS precursor cells followed by temporally controlled gene expression. Apart from transforming our understanding of the largest division of the peripheral nervous system and fundamental developmental processes, DeSTENy will open avenues for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Processing of Mesoscopic Time-pulsed Entangled Optical fields', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Quantum physics is promising to start a revolution in the way we conceive the treatment of information. Future quantum computers will be able to solve complex problems for which an efficient solution is now difficult to implement. Their construction will require an unprecedent level of accuracy in manipulating quantum systems; quantum properties of light are appealing for this project, both at a “microscopic” regime, adopting single photons, and at a “mesoscopic” regime, employing the quadrature components. It has been proposed that “cat states” of light, i.e. a superposition of almost orthogonal coherent states, can encode qubits; this architecture requires the least overhead resources for fault tolerance among all the proposed optical quantum computation schemes. A key requirement is the ability of generating highly nonclassical states, whose quasi-probability function can assume negative values; earlier demonstrations have shown that such states can be generated by manipulating one- and two-mode squeezed states with a merging of both continuous variable and single photon experimental techniques. This project is devoted to the maturation of this approach, by generating two-mode entanglement of cat states, an essential resource for building quantum gates. For this purpose, we aim to improve the technology allowing the generation of number states and cat states. First, we will achieve a high level of squeezing, in order to manipulate optical fields with a larger degree of nonclassical correlations. Then, we will produce multi-qubits by using multiple squeezers. Finally, we will improve the single photon detections by using photon number resolving detectors. We expect that these innovations will improve the accuracy of state manipulation: the assessment of the usefulness
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Non perturbative study of m-theory' under Fourth Framework.

assistant: **Concept**

Research objectives and content The study of theories based on extended objects namely strings opens a very promising avenue towards the resolution of the most important problem in the physics of the fundamental interactions namely the reconciliation of quantum mechanics with general relati- vity . Recently, fundamental and very impressive progress has been realized in the comprehension of superstring theories which led to the key discovery that the five consistent superstring theories appear to describe one unique theory in different regions of the couplings . This unique theory has received the name of M-theory and its low-energy limit corresponds to eleven dimensional supergravity . Recently, a very interesting and promising proposal for a non- perturbative formulation of M-theory has been made in term of a Matrix theory . In this project we plan to explore all the promising avenues which could lead to significative progress in our under- standing of M-theory . In particular, we plan to address the open question of the description of M-theory compactified down to ' realistic ' space-time dimensions . Training content (objective, benefit and expected impact) As a young researcher, to be in Imperial College would permit me to deeper my knowledge and pursue my research in an ideal environment and would certainly constitute a crucial stage in my career . Links with industry / industrial rdevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'NOVEL TREATMENT OF ACUTE ON CHRONIC LIVER FAILURE USING SYNERGISTIC ACTION OF G-CSF AND TAK-242' to be submitted under Horizon 2020.

assistant: **Abstract**

In Europe, about 30,000 people die every year from alcohol related cirrhosis, a form of chronic, non- communicable disease. The patients that are at highest risk of death are those with superimposed alcoholic hepatitis (AH) who do not respond to therapy and develop acute on chronic liver failure (ACLF), a newly described syndrome characterised by multiorgan failure. Treatment of ACLF is an unmet need. Based upon their clinical and pre-clinical studies, the A-TANGO consortium aims to perform Phase 2 clinical trials of a novel, patented and innovative therapeutic strategy by repurposing a toll-like 4 receptor antagonist (TAK242, Technology Readiness Level (TRL) 8), which targets inflammation, and combining it with granulocyte colony-stimulating factor (G-CSF, TRL9) that improves hepatocyte proliferation (G-TAK, TRL4). A successful trial will advance G-TAK to TRL8. Additionally, A-TANGO aims to discover novel biomarkers for patient selection and defining prognosis, building health economics models and reimbursement strategies to allow maximal dissemination and exploitation. The A-TANGO Consortium includes the inventors of G-TAK (UCL, Charit, ULEI and LUMC) and will deliver the project aims through EFCLIF, which has a network of 110 European hospitals. YAQ and HPX are SMEs that own the background IP and will ensure regulatory approval, study Sponsorship and drug supply. APHP and IMAC will deliver the economic models. Concentris will manage the project and together with EASL, CHX and ELPA will engage with patients, initiate widespread dissemination activities and allow exploitation of the results. Gender balance will be maintained throughout the project duration. A-TANGO will achieve the expected impacts of producing meaningful advances in clinical practice by reducing the m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing Plasma-assisted ammonia technology for decarbonisation of power production' in the context of a Horizon 2020 call.

assistant: **Objectives**

This proposal aims to benefit from the low-cost storage of liquid ammonia as a carbon-free hydrogen alternative energy resource and mitigate associated issues to its utilisation to replace hydrocarbon fuels in existing gas turbine engines (GTEs) for power production. It is built up ongoing projects at the Gas Turbine Research Centre (GTRC), where currently ammonia flames are investigated, experimentally. Two challenging aims have been identified: (i) to enhance the reactivity of ammonia/air mixtures and improve the fundamental combustion characteristics of ammonia for use in GTEs; (ii) to optimise the existing burner for operating with pure ammonia while maintaining high fuel efficiency and low combustion emissions. The novelty of the current project relies on the fundamental study of plasma-assisted combustion to improve the reactivity of ammonia rather than currently used approaches by blending of the ammonia molecule with more reactive fuels (i.e. hydrocarbons, hydrogen, etc.).  The concept will ensure faster ammonia/air reactivity by modifying the kinetics of oxidation based on the concept of plasma-assisted combustion, avoiding the blending of the ammonia molecule with more reactive fuels (i.e. hydrocarbons, hydrogen, etc.). The project includes both detailed physical experimentation using an state-of-the-art optical combustion diagnostic facility at GTRC, as well as detailed multi-scale numerical simulations, covering all scales of the underlying processes from atomic and molecular levels, to the smallest scales of turbulent fluctuations to the actual burner size. Timeliness of the project is ideal to support the use of ammonia as fuel in power applications, marine engines, and heavy load transportation systems. Its success contributes to the decarbonisation of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ozone soundings as a tool for detecting ozone change.' to be submitted under Fourth Framework.

assistant: **Abstract**

1. To measure the rate and extent of ozone loss both inside the Arctic vortex and at middle latitudes during the winters of 1995-96, 96-97 and 97-98. 2. To follow the ozone destruction as it develops during an individual winter and from one winter to the next. 3. To investigate the structure and duration of laminae episodes. 4. To extend the important record of ozonesonde data obtained during the last four winters. 5. To build a data base of quality controlled ozonesonde data collected since 1988. 6. To provide this and other projects with meteorological analyses and forecasts from ECMWF.The work programme consists of five work packages:  1. Purchase and distribution of sondes and sonde operation  2. Match campaign and analysis  If ozone loss occurs it will be detected by launching sondes from different stations into the same air mass a few  days apart. This is achieved by using forecast trajectories. A large number of such matching pairs is needed in  order to get a good statistics. It is the aim to investigate the ozone loss both inside the polar vortex and at  middle latitudes. Sondes launched in Canada will be used as primary sondes, and the same air mass will be  measured by the European stations.  3. Ozone laminae, climatology and trends  3.1 Mean ozone field  3.2 Ozone versus potential vorticity (PV)  The effects of dynamics will be isolated from chemical effects by considering the relative evolution of ozone  and PV.  3.3 Extension to subtropical latitudes  This activity will address changes in the ozone distribution caused by dynamical changes, which can then be  linked to the effects seen at middle latitudes.  3.4 Ozone trends on isentropic levels  The temporal evolution of the ozone mixing ratio at isentropic surfaces will be studied. Diabatic descent will  b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The utilisation of water industry waste in ceramic products', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Throughout EC Member States the population's drinking water is drawn from rivers, lakes and/or boreholes. Before distribution this water invariably requires pre-treatmert at appropriate purification plants (waterworks) for it to be brought up to the exacting quality standards required by the appropriate regulatory authorities. As a result of such treatment, the solid matter separated out from the the water accumulates as a 'sludge' and demands regular removal and disposal. In common with many other utility by-product wastes, the problem of finding a satisfactory long-term disposal solution for this sludge is of growing concern, exacerbated by the relevant disposal legislation which is becoming increasingly more stringent. The United Kingdom, the Republic of Ireland anc Greece are three Member States in which this particular disposal problem is becoming acute. Currently, the only solution available is for its burial in landfill sites. However, rising costs and he generally reducing availability of suitable places conveniently close to sources of major sludge production, has led to an active interest in seeking alternative disposal solutions. Preliminary research within the Ceramic Technology Section of Staffordshire University has identified that with proper pre-treatment and mix-design modification, such sludge may potentially fulfill a useful role in ceramic products. In particular, specialist ware such as refractory items and vitrified pipes. The objective of this CRAFT proposal is to promote participation between a wide range of ceramic manufacturers (SME's) in Member States and appropriate educational/research organisations with the aim to establish the regular inclusion of this sludge into such products, consequently demonstrating its commercial viability as a prac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'STrain ENgineered Spatial light mOdulators based on 2D semiconductors' (StEnSo).

assistant: **Concept**

The main goal of StEnSo is to explore a new concept of spatial light modulators based on strain engineering of two-dimensional semiconducting materials. Spatial light modulators allow for the creation of two-dimensional light patterns and have found many applications in photonics: image projection, holography, aberrations correction, laser surgery, optical tweezers, etc. These devices typically consist of an array of pixels that individually control the phase or amplitude of light passing through it or reflecting off it. In StEnSo I will exploit the large refractive index tunability of 2D semiconducting materials upon mechanical deformation, studied in my ERC StG 2D-TOPSENSE, to fabricate a new concept of spatial light modulator device.


**Keywords:** light modulation, 2D materials, strain engineering, flat optics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'International Human Microbiome Standards'.

assistant: **Objectives**

A detailed understanding of human biology will require characterisation of the human-associated microorganisms, the human microbiome, and of the roles these microbes play in health and disease. Large projects in Europe, the United States, China and Canada target these objectives, using high throughput –omics  approaches. Given the complexity of our  microbial communities, composed of thousands of species and differing considerably between individuals, as well as the multitude of effects they have on our biology, none of the projects can hope to achieve their comprehensive characterisation. To progress most efficiently towards this ambitious goal it is of utmost importance that the data generated in each individual project be optimally comparable across all the current projects and those yet to come. Our proposal seeks to coordinate development of standard operating procedures and protocols, which will optimize data comparisons in the human microbiome field and thus improve the synergy between all the projects.  It focuses on three key aspects of data generation: (i) human sample collection, processing and identification via the associated metadata; (ii) DNA sequence quality obtained by the new generation methods from complex microbial mixtures; (iii) analysis of DNA sequence in conjunction with the metadata. Importantly, it organises public access to the standard operating procedures and protocols and enables exchanges between the users and providers of the standards. It gathers very strong international partnership that includes leaders in the field and represents the current large projects, which span three continents, Europe, Asia and America. Furthermore, it interfaces via the International Human Microbiome Consortium with additional projects from Africa and Austral