RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Caspase-independent cell death: a new tool to combat cancer' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Apoptosis (Programmed Cell Death) accounts for the strictly controlled disposal of superfluous, damaged, mutated or ectopic cells. Indeed, deficient apoptosis is frequently involved in early cancer development, and the resistance of tumours to chemo- or radiotherapy. Thus, the comprehension of normal and pathological regulation of apoptosis should provide conceptual advances for therapeutic interventions on deficient cell death. Evidence from an increasing number of experimental systems supports the notion that apoptosis can proceed in a caspase-independent manner. However, there is no exhaustive work characterizing both the principal agents involved and the pathways implicated in caspase-independent cell death. This is the goal of the proposal. One of the main agents of caspase-independent cell death is AIF (Apoptosis Inducing Factor). Following an apoptotic stimulus, AIF translocates from mitochondria to the cytosol and the nucleus, where it induces in cooperation with unknown factor/s. mitochondrial swelling, loss of the mitochondrial transmembrane potential, phosphatydilserine exposure, and large-scale DNA fragmentation. Recently, it has been demonstrated that the activation via antigen CD47 in B-lymphocytes from B-chronic lymphocytic leukaemia induces a form of cell death, without caspase activation, characterized by the externalisation of phosphatydilserines and the fall in mitochondrial transmembrane potential. Thus, CD47-induced cell death is an ideal model to study the signalling pathways implicated in caspase-independent apoptosis and the contribution of AIF to the execution of this kind of cell death both in normal and pathological situations. The combination of a through knowledge of the biochemical and molecular mechanisms involved in CD47 cell death, and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Translation for Massive Open Online Courses' (TraMOOC), addressing dissemination and exploitation.

assistant: **Impact**

Massive Open Online Courses have been growing rapidly in size and impact. Yet the language barrier constitutes a major growth impediment in reaching out to all peoples and educating all citizens. TraMOOC aims at tackling this impediment by developing high-quality translation of all types of text genre included in MOOCs (e.g. assignments, tests, presentations, lecture subtitles, blog text) from English into eleven European and BRIC languages (DE, IT, PT, EL, DU, CS, BG, CR, PL, RU, ZH) that constitute strong use cases, are hard to translate into and have weak MT support, thus complying with the call objectives. Phrase-based and syntax-based statistical machine translation models will be developed for addressing language diversity and supporting the language-independent nature of the methodology. For a high quality, automatic translation approach and for adding value to existing infrastructure, extensive advanced bootstrapping of new resources will be performed. An innovative multi-modal automatic and human evaluation schema will further ensure translation quality. For human evaluation, an innovative, strict-access control, time- and cost-efficient crowdsourcing setup will be used. Translation experts, domain experts and end users will also be involved.  Separate task mining applications will be employed for implicit translation evaluation: (i) topic detection will be applied to source and translated texts and the resulting entity lists will be compared, leading to further qualitative and quantitative translation evaluation results; (ii) sentiment analysis performed on MOOC users’ blog posts will reveal end user opinion/evaluation regarding translation quality. Results will be combined into a feedback vector and used to refine parallel data and retrain translation models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Light INduced Cell control by Exogenous organic semiconductors' (LINCE).

assistant: **Concept**

LINCE will develop light-sensitive devices based on organic semiconductors (OS) for optical regulation of living cells functions.The possibility to control the activity of biological systems is a timeless mission for neuroscientists, since it allows both to understand specific functions and to manage dysfunctions. Optical modulation provides, respect to traditional electrical methods, unprecedented spatio-temporal resolution, lower invasiveness, and higher selectivity. However, the vast majority of animal cells does not bear specific sensitivity to light. Search for new materials capable to optically regulate cell activity is thus an extremely hot topic. OS are ideal candidates, since they are inherently sensitive to visible light and highly biocompatible, sustain both ionic and electronic conduction, can be functionalized with biomolecules and drugs. Recently, it was reported that polymer-mediated optical excitation efficiently modulates the neuronal electrical activity.LINCE will significantly broaden the application of OS to address key, open issues of high biological relevance, in both neuroscience and regenerative medicine. In particular, it will develop new devices for: (i) regulation of astrocytes functions, active in many fundamental processes of the central nervous system and in pathological disorders; (ii) control of stem cell differentiation and tissue regeneration; (iii) control of animal behavior, to first assess device biocompatibility and efficacy in vivo. LINCE tools will be sensitive to visible and NIR light, flexible, biocompatible, and easily integrated with any standard physiology set-up. They will combine electrical, chemical and thermal stimuli, offering high spatio-temporal resolution, reversibility, specificity and yield. The combination of all t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'A flexible production system for customized windows and doors'.

assistant: **Objectives**

The technical and scientific objectives are to: develop a prototype of an integrated, automated, highly flexible production system for semifinished parts to be used in windows and doors, produced in very small batches or as customized one-of-a-kind products. develop on scanning, vision system and control software which can handle every single piece of wood entering the production by identifying and controling in a way that its position and orientation is known by the control system during all steps of the process. develop a computer algorithms for sorting and mechanical devices for handling, storing and transportation so the pre-cut blanks are sorted according to their lengths and stored internally in the system in a buffer prior to transfer to the moulding machine. One production batch has approx. 800 individual pieces. develop the architecture and suitable interfaces with existing software programs. The aim is an integration of CAD design, order handling, production and stock control and machine tool control to facilitate minimum lead time and maximum productivity, even with extremely small order sizes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolution on the Balkan Peninsula: Phylogeny and phylogeography of the genera Edraianthus and Heliosperma' (EVOBALK).

assistant: **Concept**

Many surveys confirm that the Balkan Peninsula in general is a hotspot of European biodiversity, but the extremely high level of endemism in the Balkans is probably the most striking element. In order to contribute to an explanation of this phenomenon, we use two model plant genera (Edraianthus, Heliosperma) to address the following objectives within the project: establishment of sound molecular phylogenetic hypotheses on the relationships of the study groups both to its closest relatives as well as within the respective genera; testing the Pleistocene speciation hypothesis; establishment of sound comparative phylogeographic hypotheses within species and species groups; pinpointing the putative centres of origin of the respective groups based on the phylogen etic and phylogeographic pattern; determining the migration paths from the Balkans to the Apennines; determining frequency and timing of the colonisation of the Apennines and pinpointing secondary centres of origin in the Apennines. Material of all species of the study groups will be collected in the field. Research will be carried out applying modern molecular methods [DNA-sequencing, cpDNA haplotype analysis, DNA-fingerprinting (AFLP), molecular dating], cytogenetic analyses, morphometrics, and biogeograp hic analyses. Despite its recognized importance as a diversity hot spot in Europe, the Balkans has only been marginally, if at all, included in such studies. The synthesis of our results will yield a much broader basis to address the questions going far be yond the groups investigated: biogeography of southern Europe, e.g., centres of diversification or migration routes, and delimitation of species by comparison of the genetic divergence of taxa. These results are also of high relevance for conservation effo rts,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evolution and development in Myxozoa: body-plan simplification associated with endoparasitism' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Myxozoa are endoparasitic animals that exploit invertebrates and fish. Their phylogenetic position has long been controversial. However, recent placement within Cnidaria makes it clear that myxozoans have undergone astonishing morphological simplification associated with the evolution of parasitism. Such simplification is characteristic of many parasites but the genetic and developmental bases are poorly understood. Myxozoa demonstrate perhaps the most extreme example of simplification known to date, lacking a nervous system, gonads, cilia and centrioles. Differing degrees of simplification within the group provide an ideal opportunity to investigate the genetic and developmental bases of morphological simplification in a comparative approach. The myxozoan Buddenbrockia plumatellae forms muscular worms with a polarised body plan while the very closely related Tetracapsuloides bryosalmonae occurs as simple, unpolarised sacs. This fellowship proposes to generate transcriptomes of developmental stages from these two species by next-generation sequencing. Resulting data will be used to (i) compare developmental gene repertoires and expression levels of the two species and (ii) identify how myxozoans are related to other cnidarians. In a second step, expression patterns of developmental genes will be analysed by in situ hybridization. A third step will characterise the morphology and ultrastructure in regions of gene expression. Collectively, these investigations will provide a comprehensive picture of myxozoan development that can be compared to patterns in other myxozoans and free-living cnidarians. The research will (i) produce novel insights about morphological simplification associated with parasitism (ii) advance our understanding of a previously unrecognized radiation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Wireless World Initiative-Ambient Networks: Create a pervasive, reliable communication environment hiding the heterogeneous infrastructures, supporting the ever-changing needs of users and services"' (2002-2006).

assistant: **Innovation**

The Ambient Networks project will create the network solutions for mobile and wireless systems beyond 3G. It will enable scalable and affordable wireless networking while providing rich and easy to use communication services for all. It is geared towards increasing competition and cooperation in an environment populated by a multitude of user devices, wireless technologies, network operators and business actors. Ambient Networks offers a fundamentally new vision based on the dynamic composition of networks to avoid adding to the growing patchwork of extensions to existing architectures. This will provide access to any network, including mobile personal networks, through instant establishment of inter-network agreements.The project adopts the design paradigm of horizontally structured mobile systems that offer common control functions to a wide range of different applications and air interface technologies. Such a radical change requires the definition of new interfaces and a multitude of standards in key areas of future media- and context-aware, multi-domain mobile networks. The project's results comprise a complete, coherent wireless network solution; an architecture for self-configuring network components that reduces deployment and operational costs and a complete protocol suite for network composition evolved from IPv6.The results will facilitate incremental market introduction of new services, and will stimulate sustainable growth in the European mobile communications sector. Ambient Networks brings together a strong industry led consortium of the leading operators, vendors, SMEs, and research organisations, with the determination, skills and critical mass to create cross-industry consensus and to drive standardisation. The project is defined over 3 phases. The fir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Developing drought-resistant cereals to support efficient water use in the Mediterranean area' (CEDROME).

assistant: **Concept**

Limited water resources are now a major challenge to World food security esp. in many developing countries such as those in the Mediterranean basin. Cereal cultivation, including rice and wheat, requires a tremendous amount of water, and any deficiency can severely affect yield. CEDROME aims to develop drought resistant cereals to support the efficient use of water supplies in the Mediterranean area. Additionally, development of drought resistant cereals will also facilitate increased agricultural productio n by making use of large areas of yet underdeveloped dry lands. With the available genomic sequence, the well-defined genetic maps and large collection of mutation and insertion lines, rice is the obvious model for this research. The knowledge obtained and functional genes identified from rice can be extrapolated in the improvement of other cereal crops such as wheat, barley and sorghum since they are closely related. This multi-disciplinary project combines European and MPC expertise in classical breeding, plant physiology and cereal crop biotechnology to assist the development of a new generation of wheat and upland rice varieties with enhanced drought resistance. 2 Chinese partners in this project provide expertise in cereal biotechnolog, as well as valua ble breeding tools and materials. Molecular markers will be used to identify drought-related loci. Conventional breeding will be used to combine drought resistance genes in new cultivars and new candidate drought resistance genes will be identified. Constr ucts will be made with these new and existing putativedrought resistance genes and transgenic rice and wheat plants will be evaluated in various countries under different growing conditions. In addition genetic approaches will be taken to identify new gene s fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A heterogeneous distributed prediction model for wind-solar energy production' (ANSWER).

assistant: **Innovation**

To achieve the European Union's green transition goal, solar photovoltaic (PV) and wind energy are widely adopted, which pose great challenges to the reliability and safety of existing energy systems. The state-of-the-art methods mainly concentrate on the prediction of a single energy form, either wind or solar. There is limited research on joint forecasting for wind-solar energy due to the challenges of data heterogeneity and data silos for different wind farms and solar PV plants. This project develops a heterogeneous distributed prediction model for joint wind-solar energy production (ANSWER),  based on heterogeneous data sources at different wind farms and solar PV plants. A global model will be generated by the fusion of heterogeneous models from all wind farms and solar PV plants, coordinated by a central server. To achieve the research goal, this project proposes four work packages, including 1) development of model specifications,  which use a two-level structure:client-level and server-level, 2) development of a generic seamless forecasting client model that supports multiple time-scale and -horizon prediction, 3) model aggregatioin for heterogeneous client models, and 4) model deployment and evaluation in a living lab for the robustness of the proposed ANSWER model. This proposal ANSWER specifies the resources needed for this project, including the quality and capacity of the host university, mentors, data, and experimental facilities. This project will enhance the scientific skills and innovation capability, expand research horizons, and establish research collaborations of the applicant. A two-way knowledge transfer approach in energy big data, distributed modeling and energy system analysis is proposed to ensure benefits between the applicant and the host u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Car & truck lighting analysis: ratings and evaluations for safety & comfort objectives' (CLARESCO) under Fifth Framework.

assistant: **Objectives**

The CLARESCO project aims at improving traffic safety and truck & car-drivers' comfort during nighttime driving. This will be achieved by analysing human perception and behaviour in dynamic lighting situations using adaptive rear and front lighting technologies, traffic and environmental conditions. Those aims will be carried out through the use of innovative real-time simulation tools by specifying assessment procedures and evaluation methodologies that focus on safety and comfort. As a consequence, safety, ergonomics and comfort recommendations concerning new lighting technologies for truck and car will be worked out.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Atlas'.

assistant: **Objectives**

The human subcortex is a highly crowded brain area, which consists of hundreds of unique, small grey matter nuclei constituting approximately ¼ of total human brain volume. Importantly, only approximately 7% of these nuclei are currently accessible in standard human brain magnetic resonance imaging (MRI) atlases (Forstmann et al., 2016). This low percentage can have several imaging related causes, including the small size of subcortical nuclei as compared to the voxel size, which is particularly relevant when applying 1.5 or 3 Tesla (T) MRI. Additionally, the challenges posed by the large distance of the subcortex from the head coil may be a cause. In light of the vast amount of uncharted brain areas, one can also think of the human subcortex as ‘terra incognita’. The aim of this proposal is to chart ‘terra incognita’ to create a tool to identify and localize new targets for DBS.  Major efforts of my group have already been directed towards resolving at least part of the challenges of imaging the human subcortex through the development of ultra-high field resolution 7T magnetic resonance imaging (UHF-MRI) sequences tailored to image the subcortex. Within our project ‘Atlasing the human subcortex’, collaborations with world-leading companies in DBS technology such as Boston Scientific (http://www.vercise.com/index.cfm) have been established. Here, we aim to extend these efforts by applying for funding for research personnel that will execute the manual segmentations and validation of new potentially more efficient target areas for DBS neurosurgery. These efforts will lead to creating probabilistic atlas maps for DBS surgery with unprecedented detail as well as a 3D app for educational purposes both in the clinical and basic neurosciences. These efforts will ultimately le