RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FROM STEREOTOMY TO ANTISEISMIC CRITERIA: CROSSROADS OF EXPERIMENTAL DESIGN. SICILY AND MEDITERRANEAN  (XII-XVIII CENTURY)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Over the centuries, Sicily has known an unequalled variety of building experiences. Strategically located, the largest Mediterranean island has served as a centre for the dissemination of innovative solutions, as well as a collector of ideas from multiple sources. This intellectual interchange is clearly evident in the long history of stereotomy or stone construction. A rich tradition of advanced stone cutting (domes, cross vaults and complex stair solutions), evolved through experimentation and importation. Initially solutions from the Byzantine world and North Africa were influential. A wider experimentation occurred during the Renaissance. In this era new technologies often related to seismic concerns and involving the use of lighter structures stimulated innovation. The multiple earthquakes that struck the island initiated a fascinating and, in some ways, effective series of experiments in the field of anti-seismic construction technology.This project aims to investigate building criteria applied between the Middle Ages and the Modern era in the Mediterranean basin, with a particular attention to Sicily and other big islands, southern Italy, eastern Spain, North Africa and near East. Measurements, surveys, and the material knowledge of the building techniques will be intertwined with the tools of the historical investigation. Research will study geometric, constructive and formal models and chart their origins and routes of development. A most challenging aspect of the project is the verification of the flow of ideas in the Mediterranean, in order to show a less simplistic image of the history and of the civilizations that here faced. It is expected to have a relevant scientific and social impact, modifying scholars' attitude on the investigated topics and laying th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploring the dark matter of the human genome: systematic discovery of microRNA genes using high-density oligonucleotide tiling arrays and comparative genome analysis' in the context of a Sixth Framework call.

assistant: **Objectives**

Protein-coding sequences represent only a tiny fraction of the human genome. Since biologists have started to explore the puzzling remainder, the 'dark matter' of the genome, the number of known non-protein-coding genes has been growing rapidly. In particular hundreds of genes encoding microRNAs (miRNAs), regulators of key molecular processes in animals and plants, have been identified over the last five years and recent studies indicate considerably higher gene numbers. As non-coding RNA genes are often less evolutionarily conserved than protein-coding genes, and mature miRNAs are hard to clone, novel sensitive approaches are required for their identification. We propose an interdisciplinary approach for discovering RNAs that combines high-throughput functional genomics, nucleotide sequence analysis, and comparative genomics. In particular, we intend to utilise a series of high-density oligonucleotide tiling arrays, which enable the sensitive measurement of transcription on the entire non-repetitive sequence (sense and antisense strands) of the human genome at high (<40 nucleotide) resolution. The approach will cover the following steps:(1) detection of transcribed genomic regions;(2) identification of regions unlikely to encode proteins;(3) detection of evolutionarily conserved blocks of DNA;(4) examination of such regions for typical properties characterising known non-coding RNA genes, e.g. stem-loop-forming potential and specific patterns of conservation.The project will involve a tight collaboration between the host laboratory and the experimental group of Michael Snyder at Yale, both experts in constructing and analysing tiling arrays. As tiling arrays allow an unbiased search for biologically relevant regions, are sensitive, and can be readily applied to distinc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Evaluating how pleiotropy influences genetic and developmental evolution by using rodent teeth' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Pleiotropy is the phenomenon of one gene affecting several phenotypic traits, such as different organs. Mutations advantageous in one organ often have antagonistic effects in others. Recent theoretical and empirical data suggest adaptation proceeds with such pleiotropic mutations if they are compensated during development. I think that pleiotropy may promote the fast divergence of developmental gene expression and cis-regulatory regions while selecting for such compensations.To test this, my labs model, the upper and lower molars in rodents, will be ideal to: -Link variation in genes, development and shape, and track compensations in developmental processes. -Focus on a tractable case of pleiotropy with two organs. -Compare the evolution for different pleiotropy constraints. We have established a collection of rodents and methods to compare their genomes and developing molars.PLEIOTROPYs originality is to contrast 3 types of species: Ancestor-like molars (controls), and derived molars that evolved either in line with pleiotropy constraints (higher crowns in both molars), or against them (extra cusps only in the upper molar). Our hypothesis implies that gene expression and cis-regulatory regions evolve faster in the latter case. We will: 1) Compare how developmental gene expression in tooth germs evolve, and search for compensatory changes in developmental mechanisms. We will scan gene expression at spatial resolution in 7 focal species. 2) Survey how regulatory regions evolve, and test compensatory mutations. We will annotate regulatory regions from epigenomic data and infer their phylogenetic history in 67 species. We will screen and validate compensatory mutations. 3) Model the joint evolution of upper and lower molars development to predict rates of genome evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification and characterization of novel EGFR interactors and their implication in cancer signalling' to be submitted under Seventh Framework.

assistant: **Abstract**

One of the major challenges of modern molecular biology is to understand how healthy cells transform into malignant, proliferating cells leading to diseases such as cancer and which proteins trigger these aberrant signalling cascades. The ErbB family of receptor tyrosine kinases (RTKs) are pivotal mediators of the signalling network that transmit extracellular signals into the cell and control cell growth, proliferation, differentiation and survival. Excessive ErbB signalling arises from receptor overexpression or mutation and is a hallmark of various cancers. Yet, despite 25 years of in-depth studies of RTK signalling, some aspects remain elusive and deeper understanding of signalling pathways downstream of mutant receptors will likely improve current EGFR-targeted therapies. Hence, the main aim of this proposal is to identify novel players in EGFR signalling as potential novel cancer drug targets. This will be achieved by transferring a novel two-hybrid technique that I have developed during my previous postdoc to the host institution and combining it with their expertise in cancer signalling. I will a) perform interaction screens to identify novel interactors of EGFR and its cancerous variants and b)  perform small molecule compound screens to identify drugs that can interfere with interactions that specifically occur with these oncogenic EGFRs. Our ultimate goal is to identify chemical compounds that can be taken further to therapeutic development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Lagrangian approach to understand upper ocean processes' under Seventh Framework.

assistant: **Concept**

The ocean is an important part of the earth climate’s system, contributing to transport the excess of heat from the equator to the northern latitudes. The air-sea interaction and most of the biological productivity occur in the upper ocean. Despite that, the precise physical processes that govern the ocean surface circulation are still not well defined. The objective of this proposal is to advance in the understanding of the physical processes that govern the upper-ocean circulation of the oceanic subtropical gyres, by focusing in two complementary systems, the Kuroshio Current (outgoing phase) and the Canary Current (return phase), the western and eastern components of the north Pacific and Atlantic subtropical gyres. The particular scientific objectives will be approached by way of an innovative methodology that combines surface lagrangian velocities and satellite data. Surface lagrangian observations provide now a days the most accurate and feasible representation of surface ocean circulation at open and coastal ocean. This methodology, recently developed by the outgoing research group, will permit to obtain the first detailed analysis of the actual surface circulation patterns of both areas. The outgoing phase will be carried in one of the world’s most prestigious ocean research organizations, the Scripps Institution of Oceanography (USA). Data analyses and evaluation of results will be jointly carried out with scientist with wide expertise in the proposed scientific and methodological topics, and in the framework of current multidisciplinary experiments of the outgoing host group. The return phase, in one of the leading European centre for ocean research, the Instituto Español de Oceanografia (Spain), will permit to capitalize the experience and training acquired,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Policy-Assessed system-level Security of Sensitive Information processing in Virtualised Environments' (PASSIVE).

assistant: **Innovation**

Virtualised service platforms and cloud computing hold great promise for delivery of large applications in e-Government. However, to date, the fundamental shared-resource nature of virtualisation technologies has raised legitimate security concerns for Government and other organisations with duties to protect confidential data.The PASSIVE project proposes an improved model of security for such virtualised systems to ensure that:*\tadequate separation of concerns (e.g. policing, judiciary) can be achieved even in large scale deployments*\tthreats from co-hosted operating systems are detected and dealt with;*\tpublic trust in application providers is maintained even in a hosting environment where the underlying infrastructre is highly dynamicTo achieve these aims, the consortium proposes:*\tA policy-based Secuirty architecture, to allow security provisions to be easily specified, and efficiently addressed.*\tFully virtualised resource access, with fine-grained control over device access, running on an ultra-lightweight Virtual Machine Manager.*\tA lightweight, dynamic system for authenticaiton of hosts and applications in a virtualised environment.In so doing, PASSIVE will lower the barriers to adoption of virtualised hosting by government users, so that they may acheive the considerable gains in energy effiiciency, reduced capital expenditure and flexibility offered by virtualisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Determination of the Fate of Inorganic Components upon Gasification of Sewage Sludge' under Seventh Framework.

assistant: **Concept**

Gasification is a promising technology for the production of renewable energy resources from biomass and waste streams, offering the advantage of providing a safe disposal route for organic pollutants. However, a major concern is the unclear fate of inorganic components during gasification, which brings about several environmental and technological issues. Because of its elevated content in N, P, S and heavy metals, sewage sludge forms an excellent model compound for a biomass waste stream with high inorganic loading. Hence, the current study focuses on elucidating the distribution and environmental risks of a series of target inorganic components into the gas phase, char residue and condensate, upon sewage sludge gasification. Hereto, an experimental study will be performed on bench scale, including advanced and complimentary chemical analyses, both on-line and off-line (GC-TCD, FTIR, ICP-AES, X-ray microfluorescence, X-ray diffraction and elemental analysis). The obtained experimental data will be used to develop strategies for clean gas production by operation at selected temperature stages and to extend existing gasification models with reaction mechanisms for inorganic components. Finally, the gathered know-how will be verified and updated through a pilot scale study. In view of the project management, a detailed workplan is set up, split into five subobjectives. The project results will contribute to European excellence by the dissemination of research results through international publications, possible patents and a workshop, allowing an immediate and clear impact on technology and legislation development. The scientific project and its many complimentary training aspects will allow the candidate to pursue and consolidate a European research career in the fields
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Future Internet Gateway-based Architecture of Residential Networks' (FIGARO).

assistant: **Innovation**

The Internet has evolved from a technology-centric core network to a user- and content-centric network that must support millions of users creating and consuming content. It must accommodate new services with new requirements and cope with heterogeneous network technologies. The momentum is moving toward the end user who is now capable of creating, storing, and delivering content and services. FIGARO proposes a Future Internet architecture that is structured around residential networks. In this architecture, home gateways have a key role as integrator of different networks and services, and as coordinator of Internet-wide distributed content management. FIGARO will: i) design a novel content management architecture that enables distributed content backup, search and access. This architecture will also support mobile users and wireless ad-hoc content sharing; ii) develop a network optimization framework, leveraging community networks and heterogeneous networks; iii) deliver a network management architecture which includes new network monitoring and real-time troubleshooting techniques; iv) explore novel Internet-based communication and service solutions for emerging sectors, such as energy management and e-health care.We will deliver the components of the FIGARO architecture through an experimental approach incorporating testbed prototyping of solutions. In summary, FIGARO is intended to evolve the current Internet to meet future demands of applications, services and end-users, while preserving its current robustness and increasing its scalability and efficiency. Furthermore, the integration of new sectors into the future Internet will spur trans-sector innovation and create new businesses. The project is expected to result in technologies that will strengthen Europe's p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'This 3 day conference will be focused to the financial instruments, facilities and measures launched under Horizon 2020 to enhance access to finance for research, innovation and SMEs.' to be submitted under Horizon 2020.

assistant: **Abstract**

The overall aim of the project is a 3 day High level international conference, which will raise awareness of the potential for the financial instruments and accompanying measures launched under Horizon 2020 to enhance access to finance for research, development and innovation. The role of the preparation of the investment project provided by Innovfin advisory will be outlined in compliance with the Political guidelin announced by President Juncker.A special attention will be given to concrete measures supporting innovative SMEs. A particular focus will be the possible interactions between Horizon 2020 financial instruments, COSME's, and European Structural & Investment Funds (ESIF), as well as with instruments at national and regional level. The event will bring together policy-makers, financial intermediaries and representatives of the research, innovation and business communities.The specific objectives of the conference are:Firstly, help businesses and other types of organisation engaged in research and innovation (R&I) to better understand how to gain access, via financial instruments, to loans, guarantees, counter-guarantees and hybrid, mezzanine, equity finance and non-banking initiatives supporting R&I.Secondly, exchange views on the implementation of Horizon 2020 financial instruments (innovfin large, innovfin midcap guarantee, innovfin mid-cap growth finance, innovfin SME guarantee, and Innovfin SME VC) and accompanying measures (innovfin advisory). Thirdly, improving the up-take of new Horizon 2020 financial instruments such as the SME Finance Initiative; the launch of a pilot facility supporting the technology transfer process; and new focuses on major societal challenges in the field of energy and infectious diseases. Finally, the European Investment Bank (E
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Photo-irradiation and Adsorption based Novel Innovations for Water-treatment' under Horizon 2020.

assistant: **Concept**

About 2.1 Billion people live without access to safe water sources. Contaminants of Emerging Concerns (CECs) such as pharmaceuticals, personal care products, pesticides and nanoparticles are increasingly being detected in wastewater and in drinking water around the world, in addition to geogenic pollutants, pathogens, antibiotic resistant bacteria and antibiotic resistance genes. Water treatment systems that remove CECs and common contaminants from wastewater and drinking water are therefore urgently needed. PANI WATER will develop, deploy and validate in the field six prototypes for the removal of contaminants, including CECs, from wastewater and drinking water. The prototypes for wastewater treatment will consist of (i) a 20,000 L/day multifunctional oxidation reactor, (ii) a 10 L/day photoelectrochemical system, and (iii) a 100 L/day solar photolytic plant. The prototypes for drinking water treatment will consist of (iv) a 300 L/hour filtration, adsorption, and UVC LED system (v) a 20 L transparent jerrycan for solar water disinfection, and (vi) a 2,000 L/day electrocoagulation, oxidation, and disinfection t system. These prototypes will be deployed in peri-urban and rural areas in India. The consortium will work closely with the communities at the fieldsites, and carry out water quality analyses, health and social impact assessments, and advocate for safe reuse of treated wastewater for irrigation, and preservation of drinking water sources. PANI technologies can find promising application among the agricultural sector, water-demanding businesses (e.g. textile, pharmaceutical), and the Indian water utilities.


**Keywords:** Rural peri-urban communities