RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Selective isolation of biopharmaceuticals with fluid zwitterionic polymeric coacervates' (CAPTOMER).

assistant: **Innovation**

Gene therapy and RNA-based therapeutics hold significant promise for treating a range of debilitating disorders. A key challenge for these therapies is the effective targeted delivery, which relies on nanovehicles to ensure the stability of the delicate nucleic acids involved. Biogenic nanoparticles, such as adeno-associated viruses (AAVs), are becoming increasingly promising for these applications, with some AAV-based therapies already receiving regulatory approval. However, maintaining the physicochemical properties essential for the efficacy and safety of these products presents significant challenges, particularly due to their complex manufacturing processes, which often result in a high degree of impurities or perturbations in their structures. Traditional bioseparation methods, such as chromatography, struggle to efficiently isolate these nanoparticles without compromising their quality.To address these issues, this project proposes a novel isolation technique for AAVs using functionalized, programmable liquid-like coacervates formed from zwitterionic polymers. Previous applications on extracellular vesicles demonstrated significant improvements in purity, yield, and processing time compared to conventional methods. The liquid nature of coacervates preserves particle integrity during isolation while their anti-fouling properties enhance specificity in capturing target molecules. This scalable approach integrates the benefits of existing purification methods, offering a gentler, efficient, and simple solution for bioseparation.Building on the success of the Consolidator ERC-funded ""VELCROproteins"" project, this initiative translates insights obtained from biological condensate research to design coacervates with tunable properties for diverse biotechnological app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'BIM-based EU -wide Standardized Qualification Framework for achieving Energy Efficiency Training'.

assistant: **Objectives**

The European Construction sector is facing unprecedented challenges to achieve ambitious energy efficiency objectives (with the aim to generalize Near-Zero Energy Buildings), in an economic crisis context dominated by reduced investments, search for cost effectiveness and high productivity. Moreover the industry is experiencing its digital revolution, with Building Information Modeling (BIM) approach gaining significant interest across Europe. Member states implement very different approaches through regulations and maturity targets, which always face the traditional low-tech and informal practices of construction businesses (a fragmented sector, dominated by SMEs). BIMEET project aims to leverage the take-up of ICT and BIM through a significant upgrade of the skills and capacities of the EU construction workforce. This Coordination and Support Action project is built around a strong consortium relying on educational and research expertise, robust experience of accrediting and labelling bodies, training supply chain and a wide engagement of industry led best practice (already committed in an EU-wide expert panel). Through its actions the project will (a) pave the way to a fundamental step change in delivering systematic, measurable and effective energy efficient buildings through BIM training with a view to effectively address European energy and carbon reduction targets; (b) promote a well-trained world leading generation of decision makers, practitioners, and blue collars in BIM for energy efficiency; (c) establish a world-leading platform for BIM for energy efficiency training nurtured by an established community of interest. Its principal outputs are 1) a skills matrix related to BIM and energy efficiency, harmonized thanks to EQF standard, and 2) a training platfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'IRB Barcelona International Postdoctoral Programme 2.0'.

assistant: **Concept**

IRB Barcelona is an independent, non-profit research institution engaged in basic and applied biomedical science at the interface between biology, chemistry and medicine, recently nominated a Severo Ochoa Centre of Excellence by the Spanish Ministry of Science and Innovation. One of the main missions of IRB Barcelona is to provide young life scientists with the opportunity to do training and research in a unique and multidisciplinary scientific environment.We are applying for contribution from the COFUND action to give continuity to the fellowship programme for postdoctoral fellows that initiated last year thanks to the contribution of a previous COFUND call: after having consolidated our PhD Programme and achieved excellent results, our aim is now to draw on the strength of this example and enhance structures and resources for researchers at the next stage of their careers. We offer postdoctoral fellows an optimal scientific environment to prepare them on their journey to take up positions as independent scientists.  The IRB Barcelona International Postdoctoral Programme will offer 16 two-year competitive fellowships, based on the Incoming mobility trans-national element. Fellows will be selected through an international committee of experts, ensuring transparency and equal treatment of all applications. The programme will be promoted internationally. Applicants will receive support throughout the selection process and awardees will be helped and mentored for the duration of the fellowship period. Postdoctoral fellows under the COFUND contribution can carry out their research projects in any of IRB Barcelona’s research programme. The programme will make significant contributions to the development of highly talented scientist’s career and to the biomedical sciences in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Aerospace sme forum' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

This proposal outlines a 15-month programme to establish a permanent FORUM bringing together European innovative AEROSPACE SMEs. These new alliances between aerospace SMEs will enhance the competitiveness of the European Aerospace industry as a whole. The European fifth framework programme will be highlighted as a key support to foster these alliances. The project will include a first set of two Alliance Workshops that will take place in connection with two matchmaking events targeting contacts between SMES and prime contractors. (which will be organised by the European Federation of high technology SMEs) These workshops will take place in Italy and France and be promoted in all the member States or Associated States. The programme will also provide on -line support thanks to a web site and individual following -up support to a hot line.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EFFECTIVE LAND MANAGEMENT FOR SURFACE RUNOFF CONTROL', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Surface runoff is determined by the intensification of agriculture and the disappeararance of grasslands in favour of cereals, root and industrial crops. In large areas under arable land, runoff is related to various environmental problems. Inside a catchment, concentrated erosion results in soil losses and formation of rills. On the other hand, dfifuse erosion results in a loss of fertiliser and pesticides by the topsoil. Concentrated polluted runoff may infiltrate at certain locations within the catchment which may increase the leaching to groundwater. Outside the catchment, the surface runoff, carrying sediment and chemicals, pollutes surface water and streams and is also on the origin of floodings and blocking of drainage systems.This project aims at defining a series of environmentally friendly land management scenarios, that minimise surface runoff. The scenarios will combine information on environment, agricultural management (soil structure after ploughing, compaction, ...) and CAP regulations, with special emphasis on the use of set-aside lands. The use of grass strips as buffer zones alongside waterways and on slopes is recommended in order to promote deposition of sediment and pollutants and limit surface runoff and erosion. A combination of applied research and modelling tools will be used to analyse the resulting runoff at the field scale (agricultural practices on soil surface roughness and infiltration characteristics) and at a catchment scale (accumulation and concentration).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Reconfigurable Intelligent Surface-Enabled millimetre Wave Communication for Beyond 5G Cellular Networks' (RISE-MM), addressing dissemination and exploitation.

assistant: **Impact**

The 5G mobile communication era has just started, and we are already experiencing the dominance of various new applications with enhanced broadband connectivity requirements. These requirements will become even more critical with the integration of cellular networks in different sectors of society. Conventional sub-6 GHz-based cellular networks represent a short-term solution, where available spectral opportunities are limited and will unquestionably dry up soon. To this end, RISE-MM aims to set the ground for the THz spectrum-based cellular networks. Combining the researcher's experience on reconfigurable intelligent surfaces (RIS)-enabled networks and the expertise on mmWave communication and its practical implementation of IMDEA Networks, in RISE-MM, we will develop channel models for RISE-MM communication in indoor and outdoor deployment settings. Moreover, the project aims to develop an algorithm for joint communication and sensing (JCAS) through RISE-MM using machine learning techniques. RISE-MM aims to validate the proposed channel models and the algorithm using system-level simulations (SLS) and software-defined radios (SDR)-based mmWave experimentation platforms. It will also implement the proposed channel models using a large testbed with tens of 60 GHz off-the-shelf devices, which will provide a more realistic performance analysis for large-scale deployments to complement the SLS and SDR-based results. The practical deployment of RISE-MM will also help formulate the optimal RIS placement policy, which is a critical factor for RIS-enabled network planning.RISE-MM is a unique scientific advance because it capitalises on communication theory, machine learning, and practical experimentation to propose new networking models to design and characterise RISE-MM commu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ToWards Immunisations that Last: the Immunology and Gerontology of Helper T cells' under Horizon 2020.

assistant: **Concept**

A major accomplishment of modern society is the extension of human life expectancy.  However, this creates a new challenge for medical science, to facilitate healthy ageing. With age, the function of the immune system declines, rendering older people more susceptible to infections and less able to benefit from vaccination. Indeed, improving vaccine efficacy is key to reducing infection-related morbidity in older people.  To date, the complexity of the ageing process has hindered attempts to fulfil this ambition, and thus innovative approaches are required to better understand the underlying biology.Vaccination creates protective immunity by inducing the germinal centre (GC) response, an intricate process that generates memory B cells and long-lived antibody-secreting plasma cells.  However, the GC response declines with age.  Strikingly, it is not B cells that are responsible for the age-dependent decline in the GC response, but the CD4+ T cells and the microenvironment of older individuals. The cellular and molecular mechanisms responsible, however, remain unknown. In the GC there are two subsets of specialised CD4+ T cells, T follicular helper (Tfh) and T follicular regulatory (Tfr) cells, which act in opposition to promote and suppress the response, respectively. I hypothesise that aberrant formation and/or function of Tfh and Tfr cells contribute to impaired GC responses during ageing, and that these cells could be targeted to improve vaccine efficacy.  Furthermore, the most prominent age-dependent change in secondary lymphoid tissues is the accumulation of senescent cells, which can modify immune function and tissue structure. I hypothesise that accumulation of senescent cells alters this microenvironment, impairing the response to vaccination. I will test these hy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polish Academy of Sciences’ Individual Fellowships: Innovation & Creativity' (PASIFIC), addressing dissemination and exploitation.

assistant: **Impact**

PASIFIC is a new Fellowship Programme, which will offer 50 prestigious two-year postdoctoral fellowships for incoming mobility. The Programme foresees the publication of two calls over the 60 months of its duration. It will provide excellent researchers from all over the world with research and complementary skills as well as transferable skills training of highest international standards that will help them to advance their scientific careers within a chosen sector, across academia, industry or a public sector. Each fellow will be hosted at one of the Polish Academy of Sciences (PAS), which is the largest and most important Polish research organisation research institutes. The PASIFIC programme will be based on individual-driven mobility.  The applicants will have freedom to choose their research area, supervisor, and secondment organisation, best suited to their individual research and career development. The programme is addressed to experienced researchers (PhD holders or researchers with at least 4 years of comparable experience). Applicants must comply with the MSCA mobility rules. The fellowships offer attractive conditions and provide participating researchers with access to the facilities and resources of the network of PAS institutes. Successful candidates will be provided with all the necessities for developing their project in the vibrant and dynamic environment of PAS, allowing them to take the next step in building their research profile and plot the best course for their future career. Fellows will be offered a living and mobility allowance 4125 EUR monthly , a family allowance (300 EUR monthly). Additionally, a host institution will benefit from hosting the researchers and will receive a maximum budget of 60 000 EUR for research costs directly linked wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'National Reference Centre for Genomics and Proteomics' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal aims at upgrading and improving the capacity of Research Centre for Genetic Engineering and Biotechnology (RCGEB), at the Macedonian Academy of Sciences and Arts for research and education in the fields of genomics and proteomics. The RCGEB is the major research, education and diagnostic facility in the field of molecular genetics and biomedical sciences in R. Macedonia which has acquired national, regional and international recognition. The RCGEB is one of the few institutions from the R. Macedonia that met the criteria for Centre of excellence due to its esteemed scientific and educational record in life sciences. The main goals of this proposal are: 1) to upgrade the RCGEB and to provide a technological platform for high throughput genomic and proteomic research that will meet the needs of the scientific community in the region; 2) to foster the networking with EU Research institutions through exchange of visits, training, collaborative projects etc.; 3) to enhance the participation of R. Macedonia in the 7th Framework Programme; 4) to promote the new trends in the field of genomics and proteomics and to disseminate the knowledge; 5) to create an improved interactive and competitive research environment that will increase the scientific carrier opportunities and will slow down the brain-drain phenomena. The MACPROGEN activities are designed to address the objectives and to bring the expected impacts of the REGPOT-2008-1 call. The MACPROGEN project will contribute to the strengthening of the research and development capacities and to the enhancement of human research potential, and will ultimately foster the integration of R. Macedonia and the region in the European Research Area. The project will stimulate multidisciplinary basic research for studying h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hazards of microplastics to the marine ecosystem: A novel mesocosm approach to evaluate the dynamic and effects of microplastic on marine organisms' health' (PlastHealth) targeting Horizon Europe.

assistant: **Abstract**

Microplastic debris pollution (MP), as a serious environmental problem worldwide, is responsible for most of the hidden marine plastic pollution, being found in organisms from algae to top predators. This innovative proposal (acronym: PlastHealth) will provide a comprehensive understanding of the transfer and effect of MP pollution, for the first time, at the ecosystem level with two main objectives: 1) assess the transfer of MPs within the three ecosystem levels, evaluating the effects of MP exposure on the health (such as the gut content, gut damage, metabolic activity and oxidative stress) using biochemical and histopathological analyses; and recovery rate of the model species using fluorescent stereomicroscopy; and 2) investigate the effects of MPs on the gut microbiome of the model species and the subsequent changes in the community dynamics of the plastisphere (microbial community formed on plastic debris) after MPs digestion by the model species using metagenomics.Going well beyond the state of the art in several fronts, a unique experimental setup that includes three functional groups mesocosm model system – a prey (arthropod Artemia salina), a predator (fish Sparus aurata), and a filter feeder (mussel Mytilus sp.). Following a highly interdisciplinary approach, and using advanced techniques, the research plan will test three MP concentrations (0, 10 and 1000 mL-1) and two MP diameters (2 and 10 μm).The strong interdisciplinary and international character of the proposal will greatly contribute to development of new skills and to the expansion of the applicant’s research network. Grounded on an effective communication strategy and with potential to deliver outputs with outstanding scientific, societal, and policy-making impact (health and safety; and environment