RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced design, monitoring , development and  validation of novel HIgh PERformance MATerials and components' (HIPERMAT).

assistant: **Concept**

The main objective of HIPERMAT is the empowering of future low carbon technologies with new materials and components by their enhanced environmental impact reduction across the value chain. At least two new bulk refractory stainless steels, a high entropy alloy and a ceramic coating will be developed through advanced modelling, hidrosolification, LMD and ceramic coatings in new beam and ring prototypes with embedded sensors in a hot stamping furnace. This objective will be achieved by setting a strong basis gathering all manufacturing conditions across the value chain: from the manufacturing of main components (beams and rings) by sand casting and centrifugal casting, the engineering in the furnace construction and the final use of the equipment in hot stamping companies.These data will be used to develop the strategies for materials selection, embedded sensors development, environmental continuous assessment, advanced modelling, data capture and main tests to be performed for material and component validation. After this, materials will be tested for high temperature performance properties such as thermal fatigue, creep, crack growth rate and wear/corrosion. In parallel, new manufacturing technologies such as hidrosolidification, LMD and ceramic coatings will be developed and tested in component like geometries towards an easier and faster approach to final solutions. All these activities will be supported by advanced modelling architecture based on a combination of thermodynamic, thermokinetics, fluids dynamics, heat interchange and metal solidification physics together with model predictive control tools based on in artificial intelligence. The combined effect of material and technologies will be finally tested in component like geometries and, once validated, transf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms of Presynaptic Biogenesis and Dynamic Remodeling' (SynapseBuild) under Horizon 2020.

assistant: **Objectives**

Our ability to move, to process sensory information or to form, store and retrieve memories crucially depends on the function of neuronal synapses. Synapses comprise a presynaptic compartment harboring the machinery for neurotransmitter release and an associated postsynaptic compartment that processes the neurotransmitter signal. During decades of research we have acquired a wealth of knowledge regarding the mechanisms of neurotransmitter release and information processing in the postsynaptic compartment. In great contrast, we know surprisingly little about the pathways that direct the formation, transport, and assembly of the complex molecular machines that make up a functional presynapse. In particular, it is unclear where and how synaptic vesicle (SV) precursors are formed in the neuronal cell body, in which form they are transported along the axon, and which maturation steps occur to allow their assembly into functional units for neurotransmitter release. How cytoplasmically synthesized presynaptic active zone (AZ) proteins that organize SV release sites are transported and assembled is equally unclear. Here, we combine genome engineering in stem cell-derived neurons and genetically altered mice with proteomic, high-resolution imaging and systems biology approaches to identify the origin and composition of SV and AZ precursors, dissect the mechanisms of their axonal transport and integration into developing synapses and unravel the pathway that controls axonal transport and presynaptic assembly of newly made SV and AZ proteins to set synaptic weight. Our high risk/ high gain studies will yield groundbreaking insights into the mechanisms that mediate the formation, maintenance, and dynamic remodeling of the presynaptic compartment during development and thereby fill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Gauge Theory as an Integrable System' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Gauge Theories provide the most successful framework for the description of nature at its most basic level, and in particular of high energy physics. However, extracting reliable predictions relevant for experiment from gauge theory has remained a major challenge which so far requires massive use of computer algebra. Over the last decade an entirely new approach to quantum gauge theories has begun to emerge, initiated by a celebrated duality between gauge and string theory. This has brought an area of science into gauge theory that seemed unrelated a few years before, namely the theory of low-dimensional statistical systems and strongly correlated electron systems. The paradigm governing this is to view ""Gauge Theory as an Integrable System"".The partners of this proposal represent different communities from gauge theory, statistical physics and computer algebra. With the proposed Initial Training Network we will carry the emerging multidisciplinary interaction to an entirely new level, bridging the gaps between our research fields in the context of graduate training activity. We believe that coordinated education of young scientists in all the tools under development from the different communities offers tremendous potential to make progress in the understanding and application of gauge theory.  This will help to secure Europe's leading role in this important area of fundamental research. A group of carefully selected private sector partners will assist dissemination of results, methods and ideas into neighboring scientific disciplines as well as to the general public. At the same time, they will also be vital in preparing the early stage researchers for active and leading roles in academia and beyond.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ENsuring Secure and Safe CMD Design with Zero TRUST Principles' (ENTRUST).

assistant: **Innovation**

Aligned with the guidelines of the Cybersecurity Act and the existing guidance on cybersecurity for medical devices, ENTRUST envisions a Trust Management Architecture intended to dynamically and holistically manage the lifecycle of connected medical devices, strengthening trust and privacy in the entire medical ecosystem. Even from the proposal stage, ENTRUST has identified gaps and necessary revisions of the current guidance (e.g., absence of post-market conformity and certification, real-time surveillance and corrective mechanisms – see 1.2.2). Towards that ENTRUST will leverage a series of breakthrough solutions to enhance assurance without limiting the applicability of connected medical devices by enclosing to them cybersecurity features. The project will introduce a novel remote attestation mechanism to ensure the device’s correct operation at runtime regardless of its computational power; will be efficient enough to run in also resource-constrained real-time systems such as the medical devices. This will be accompanied by dynamic trust assessment models capable of identifying the Required Level of Trustworthiness (RTL) per device and function (service) that will then be verified through a new breed of efficient, attestation mechanisms (to be deployed and executed during runtime). This will also enable us to be aligned with the existing standards on defining appropriate Protection profiles per device (especially considering the heterogeneous types of medical devices provided by different vendors with different requirements) including Targets of Validation Properties to be attested during runtime. The motivation behind ENTRUST is to ensure end-to-end trust management of medical devices including formally verified trust models, risk assessment process, secure lifecyc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Space-time structure', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The topics of the summer school are the recent developments in the understanding of the mathematical structure of general relativity, with emphasis on the global properties of solutions of Einstein equations. The school has an interdisciplinary character, is addressed both to theoretical physicists and to mathematicians, and part of its program has a workshop character. The time length, the topics, and the timing have been carefully chosen so that both the students and the mature scientists can see their work from a larger perspective, weight the relevance of their work to experimental and modelling applications, and can get insight into new analytical problems; however, special care has been taken to avoid an excessive inter-disciplinarily which could divert interest from the main theme of the meeting. There has been considerable progress in the field during recent years, and a school, which would give an introduction to up-to-date techniques in mathematical general relativity, has long been overdue. The gravitational wave detectors which are being constructed in Germany, Italy, as well as in Japan and the USA, will soon start collecting data, which leads to the need of better mathematical foundations of several aspects of the theory, as well as the need of young researchers trained to study such questions. Deeper insights into the mathematical structure of the theory will also be required to perform reliable numerical simulations of the expected gravitational wave data. The school is planning to address all those needs. (The date and the title of the school have been chosen to commemorate the publication in 1952 of the paper by Yvonne Choquet-Bruhat on the Cauchy problem in general relativity, which opened the door to our current understanding of an essential part of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cost effective e-business operating services for SMEs' (CEBOS).

assistant: **Innovation**

CEBOS will establish and evaluate e-Market Places (Mediation Sites) that will progressively minimize the gap between SMEs and the International on-line Market. CEBOS will provide cost-effective e-business solutions customized according to regional requirements for those SMEs targeted in the proposed Best Practice pilots. Furthermore, CEBOS will offer to the SMEs involved the opportunity to go digital under a concentrated market perspective. The Consortium includes catalyst organisations with maturity in e-Business and the necessary organizational structure to co-operate with SME associations, to prove the added-value benefits and viability of CEBOS marketplaces. CEBOS will establish and evaluate e-Market Places (Mediation Sites) that will progressively minimize the gap between SMEs and the International on-line Market. CEBOS will provide cost-effective e-business solutions customized according to regional requirements for those SMEs targeted in the proposed Best Practice pilots. Furthermore, CEBOS will offer to the SMEs involved the opportunity to go digital under a concentrated market perspective. The Consortium includes catalyst organisations with maturity in e-Business and the necessary organizational structure to co-operate with SME associations, to prove the added-value benefits and viability of CEBOS marketplaces.OBJECTIVESThe main objective of CEBOS is the establishment and evaluation of e-Market Places (Mediation Sites) that will progressively minimize the gap between SMEs and the International on line market. Through the project, CEBOS partners aim at:- Analysing European regional markets in order to identify business opportunities for on line SMEs and depict the business environment where CEBOS BPPs will operate- Analysing SME business models in order to ident
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stabilising autopolyploid meiosis for enhanced yield' (SAMEY) under Horizon Europe.

assistant: **Objectives**

Hybrid breeding has been one of the biggest contributors to yield increase of the last century. Hybrids are individuals which have genetically different parents, which results in a “hybrid vigour” effect. This hybrid vigour effect can confer advantages over inbred parent lines in growth, yield, and resilience and tolerance to different types of environmental stresses, important for securing agricultural production in a changing climate. An even greater hybrid vigour effect is possible in autopolyploids, which can have up to four different copies of each chromosome, than in diploids, which have can only have up to two different copies of each chromosome. In effect, “double hybrids” can be made in autopolyploids, with up to four different parents contributing to hybrid vigour in a single individual. However, to date the double hybrid effect has almost never been used for breeding. Most of our crops are not autopolyploids. We can induce autopolyploidy through chromosome doubling, but this causes meiotic instability, where multiple crossovers occur between the four chromosome copies during meiosis. This pairing disruption leads to potential loss of chromosomes and chromosome fragments essential for seed fertility and viability. Although induced autopolyploids are meiotically unstable, this is not the case for established autopolyploids. In the majority of established autopolyploids, a maximum of one crossover per two homologous chromosomes during meiosis is strictly enforced, thus achieving 100% pairing and correct segregation of chromosomes into daughter cells. I propose to stabilise meiosis in induced autopolyploid Brassica rapa (turnip, Chinese cabbage) by knock-out of crossover promoting genes, over-expression of crossover suppressing genes and selection of natural gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Networks Used in Globally Generic Television Systems' under Fifth Framework.

assistant: **Concept**

Introduce digital network technologies into programme production part of the broadcast chain. Development of a Rich Media network architecture based upon file manipulation and compatible with live production and public network constraints. This will modify the existing workflow and will introduce an important cost reduction on programme production. Investigate the feasibility of interchange of content as generic files over several SANs and LANs connected via MAN/WAN. A key constraint for this system will be the low or short latency to maintain real time aspects inherent to live production and flexibility to operate with adequate quality of service. Results of the project will be the design, building, testing and demonstration of a prototype "Intelligent Production System" distributed in-house and/or through public network with low latency but high data rate. Take advantage of the results of the recent IST-1999-11238 G-FORS project.OBJECTIVESDevelop a distributed and networked system architecture that addresses all areas of programme production, from capture, through conforming, to archive storage and play out. Introduce new workflow concepts to be applied for this production environment. Increase industry acceptance of MXF file interchange format, work in the refinement of MXF standard, complete the development of the MXF SDK and develop a set of applications to create and manipulate MXF files. Take dissemination actions and provide assistance in the understanding of MXF standard and the use of MXF tools. Demonstrate and test editing and conforming real programmes using this widely distributed system and generic file exchange. More generally, it is expected that the components of the system will read and understand MXF files and that they will operate in a network orien
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Intercolonial Public: Protest and Print across India and Korea, c. 1910–1947', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

INTERCOL investigates a moment of mass mobilisation at the start of the twentieth century when several non-violent protests erupted across the world. Like in contemporary demonstrations, people marched on the streets to fight for a shared idea of justice, which, for the early twentieth century demonstrators, targeted empires and colonialism. Rather than studying these mass protests within a national framework, INTERCOL excavates how non-violent anti-colonial protests were viewed across the colonies. To this end, it brings together two colonies of two different empires that underwent parallel processes of decolonisation—India and Korea. Although Indian and Korean anti-colonial actors shared similar political aspirations and methods to challenge the British and Japanese empires respectively, their interaction mostly took an intellectual form rather than physical organisation of an alliance. They debated the events and ideas unfolding across borders and incorporated them into their own assessment of anti-colonial tactics and world politics. INTERCOL uncovers these intercolonial references by examining the receptions of the Korean Manse movement in India and the Indian Satyagraha movement in Korea. By bringing to the surface the heterogeneity of intercolonial references expressed in Hindi, Korean, and English newspapers, political pamphlets, and letters of historical actors, INTERCOL lays the foundation for a new interdisciplinary subfield—intercolonial public—that offers a new approach to understanding the global anti-colonial moment in the early twentieth century. The twenty-four months of the fellowship will be dedicated to outlining the parameters of an intercolonial public, testing the benefits and limits of intercoloniality as method, and applying the implication of I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Capitalizing on apolipoprotein trafficking to deliver mRNA to the brain' in the context of a Horizon Europe call.

assistant: **Objectives**

Efficient therapeutic delivery across the blood-brain barrier (BBB) remains a significant challenge in treating neurological disorders. The BBB, composed of tightly regulated endothelial cells, severely restricts drug access to the brain, reducing efficacy and increasing off-target effects. While lipid nanoparticles (LNPs) have been essential for developing mRNA-based vaccines, their use in brain-targeted therapies is limited by poor BBB penetration and suboptimal mRNA translation.Apolipoproteins, our body’s own nanodelivery system, possess the inherent ability to cross the BBB. Extensive preliminary data demonstrate that apolipoprotein nanoparticles (aNPs) efficiently integrate mRNA for extrahepatic delivery and are a compelling platform for brain targeting. While mRNA immune cell delivery firmly established, I propose exploring apolipoprotein nanoparticles (aNPs) for mRNA delivery to the brain. The PORTAL project aims to harness the unique properties of apolipoproteins to deliver mRNA across the BBB. By screening 400 compositionally diverse aNPs—comprising apolipoprotein A1, E, and fusion apolipoproteins targeting BBB receptors—this project seeks to identify lead candidates for effective mRNA delivery to the brain. Each aNP will carry mRNA encoding Cre recombinase, along with unique DNA barcodes for detailed biodistribution and functional studies in the A14 neuroinflammation mouse model.By integrating protein engineering, RNA therapeutics, and preclinical neuroinflammation models, this research aims to uncover key factors driving BBB penetration and mRNA delivery efficiency. The innovative combination of apolipoproteins and lipid nanotechnology will unlock new pathways to the brain, setting a new standard for RNA-based treatments. Upon completion of this Program, I wi