RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Studying the Effect of Geometrical Features on Megathrust Earthquakes using Natural Observations and Seismotectonic Numerical Models'.

assistant: **Concept**

Earthquakes and associated tsunamis cause extensive human and economic losses and severe property damage in densely populated areas. The largest earthquakes occur in subduction zones, regions where one tectonic plate dives below another. To better prepare society, it is crucial to understand what controls the spatial and temporal occurrence of those largest earthquakes. Geometrical features on the seafloor that subduct with the downgoing plate, like seamounts and ridges, are thought to play an important role by segmenting the plate interface into seismic and aseismic regions. However, a physical and quantitative understanding of the role of geometrical features on the occurrence of earthquakes remains elusive due to limitations in observation time and space, as well as in modelling of crustal deformation mechanisms in 2D and 3D. SEGMENT will overcome these limitations through integrating the latest advanced forward and inverse modelling tools to study how and how much subducting geometrical features influence subduction earthquakes. Seismotectonic numerical models will be combined with probabilistic natural observations from geodesy and seafloor roughness to optimally extract complementary information and quantify elusive links. As these necessary tools are only now ready for exploration this proposal is highly timely. It will address important open questions related to how geometrical features influence the deformation at and around the plate interface, how this varies throughout multiple earthquake cycles and their role in rupture nucleation, propagation and arrest. SEGMENT thus places me in the position to make a breakthrough in a long-standing debate through providing a novel conceptual model describing the relationship between geometrical features along the subduct
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Quantum Dot coupling engineering (and dynamic spin decoupling/deep nuclei cooling): 2-dimensional cluster state generation for quantum information processing' (QCEED).

assistant: **Concept**

The overarching objective of QCEED is to find solutions to current bottlenecks to photonic quantum information processing. “Scalable” photonic universal quantum computation exploits the measurement-based quantum computing paradigm relying on multi-dimensional photonic cluster states.However, the technological capability to generate on-demand, large-scale 2-dimensional cluster states has not yet been proven.QCEED will demonstrate the (large-scale, i.e., many photons) emission of 2-dimensional cluster states of light thanks to the development of new engineered paired semiconductor quantum dot (QD) systems, and the exploitation of advanced deep nuclei cooling and/or dynamic spin decoupling to improve system coherence time.To achieve this, one needs to deterministically design QD coupling/pairing and ultimately tailor specific molecular states/architectures (lambda like energy levels). Conventionally exploited self-assembled QD systems (e.g., SK or droplet epitaxy QD systems) are in general not suited for the task. QCEED will attack the issue with a twin-track approach and demonstrate the advantage of MOVPE site-controlled (In)GaAs pyramidal QDs and CBE InAsP nanowire QDs. QCEED will also tackle the essential requirement for scalable quantum computation -that is to efficiently funnel the generated photons into specific photonic modes- by implementing tailored tapered wave-guiding designs and broadband optical cavities with relatively high Purcell factors. QCEED brings together 7 partners from 5 countries which combined possess all the complementary expertise necessary to fulfil the ambitious objectives and to prepare a post-project sustainability and exploitability plan.The combined effort will result in a new scalable platform of semiconductor sources of multidimensional c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A new perspective on the metabolic pathway to neuronal dysfunction: Using organs on a chip to elucidate the role of the brain microvasculature'.

assistant: **Concept**

Despite decades of research, the underpinnings of central nervous system (CNS) diseases and clear pathways to effective treatment remain elusive, mainly because of a scarcity of adequate models and methods with the capacity to elucidate human brain physiology. Recent studies suggest that high glucose levels are correlated with neuronal dysfunction and neurodegeneration, yet very little is known about the mechanisms of this relationship. Research in this vein has focused primarily on direct metabolic interactions between neurons and astrocytes, ignoring other cell populations in the neurovascular unit (NVU) that might have a meaningful role. My recent research revealed that the brain vasculature—the ‘gatekeeper’ through which all metabolites must pass to reach the neurons—has direct metabolic coupling with the neurons. Drawing from these observations, I adopt a previously unconsidered perspective and propose that the vasculature drives the neurodegenerative effects of hyperglycemia. Specifically, I hypothesize that high glucose levels change the metabolic function of the brain vasculature, thereby altering the direct endothelium-neuronal crosstalk and triggering neuronal dysfunction. To investigate this hypothesis, I will develop cutting-edge Organ-on-a-Chip (OoC) technology that overcomes the limitations of modeling NVU functionality and cell-cell interactions. Specifically, I will:(1) establish a human-relevant NVU-OoC model for metabolic and functional interactions, in which different cell types grow separately while remaining metabolically and functionally coupled; (2) identify the major metabolic and functional interactions in the human NVU at homeostasis and under diabetic conditions; and subsequently (3) target the vasculature communications to diminish neuronal d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining Simulation Models and Big Data Analytics for ATM Performance Analysis' (SIMBAD), addressing dissemination and exploitation.

assistant: **Impact**

The development of performance modelling methodologies able translate new ATM concepts and technologies into their impact on high-level, system wide KPIs has been a long-time objective of the ATM research community. Bottom-up, microsimulation models are often the only feasible approach to address this problem in a reliable manner. However, the practical application of large-scale simulation models to strategic ATM performance assessment is often hindered by their computational complexity. The goal of SIMBAD is to develop and evaluate a set of machine learning approaches aimed at providing state of-the-art ATM microsimulation models with the level of reliability, tractability and interpretability required to effectively support performance evaluation at ECAC level. The specific objectives of the project are the following:1. Explore the use of machine learning techniques for the estimation of hidden variables from historical air traffic data, with particular focus on airspace users’ preferences and behaviour, in order to enable a more robust calibration of air traffic microsimulation models.2. Develop new machine learning algorithms for the classification of traffic patterns that enable the selection of a sufficiently representative set of simulation scenarios allowing a comprehensive assessment of new ATM concepts and solutions.3. Investigate the use of active learning metamodelling to facilitate a more efficient exploration of the input output space of complex simulation models through the development of more parsimonious performance metamodels, i.e., analytical input/output functions that approximate the results of a more complex function defined by the microsimulation models.4. Demonstrate and evaluate the newly developed methods and tools through a set of case studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of social, genetic and environmental factors in healthy eating: a multicentre analysis of eating disorders and obesity' to be submitted under Fifth Framework.

assistant: **Abstract**

This project aims to identify psychosocial and genetic risk factors for anorexia, bulimia and obesity, and correlate these with neuroimaging and neuropsychological. We will create an aetiological model, for use as tool for improving prevention and treatment of these disorders. We will examine environment by measuring psychosocial and endogenous risk factors such as childhood obesity, sexual abuse, personality and psychopathology. We will examine the human genome for genetic risk factors in large, well-characterised European samples. We will examine the brain by performing firm and PET neuroimaging to explore neuroanatomical and neurochemical correlates, and neuropsychological to reveal cognitive factors which trigger and prolong these disorders. Finally we will model interactions between psychopathology, genes, culture, gender and psychosocial risk.We have created an aetiological model of anorexia nervosa (AN) and bulimia nervosa (BN), based on genes, environment and function of the brain. Patients who develop eating disorder have a set of identified environmental risk factors together with genetic vulnerability which together lead to the illness. In addition, there are characteristic traits such as childhood perfectionism, cognitive inflexibility, and dieting behaviour which result from the actions of both genes and environment. We identified genetic risk factors, including BDNF which appears common to both disorders, and MCR4, which is a risk factor for BN. Thus, AN and BN appear to differ for some factors (BN for example having genetic risk factors in common with obesity) and have common risks for others (such as cognitive inflexibility and many environmental risk factors). These risks manifest themselves though specific abnormalities in neural process which can be v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Liber glossarum. Edition of a Carolingian ecyclopaedia' (LIBGLOSS) under Seventh Framework.

assistant: **Objectives**

The Liber Glossarum is a very large dictionary (about 30000 entries), compiled in Northern France at the end of the VIIIth c., and combining encyclopaedic, theological, medical and grammatical sources. While being the first European alphabetical dictionary, it is still much neglected by modern scholars, principally because there exist only partial editions from the beginning of the XXth c.This project aims to provide a full edition of the text, based upon a large number of manuscripts, as well as to try and answer questions relative to its origin (which female monastery ?), its sources (which library was used ?), its link with the Carolingian educational reform movement inspired the Carolingian court.The edition will be completed within a few years, by a team composed of palaeographers, mediaevalists, and specialists of the various sources from which the authors of the Liber borrowed. The core of the project will be the Website http://liber-glossarum.linguist.univ-paris-diderot.fr/, used as a platform allowing European partners to work easily in common.Such a complete edition of the Liber glossarum intends to be a solid foundation for future scholarship, allowing also closer examination of the Carolingian manuscript tradition of the great encyclopaedist Isidore of Seville, as well as a better evaluation of the importance of the Liber for the whole lexicographical tradition of the Middle Ages. Its study is of interest from three perspectives : it will provide  better knowledge of a tool that was diffused throughout Europe; it will enhance our understanding of the role of well-read women in building the foundations of medieval culture ; and from a linguistic point of view, it will give an overview of the principles at work in the making of European dictionaries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantification of mental fatigue by means of visual and physiological measures' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mental fatigue is a symptom of many neuromuscular disorders and acute diseases and is also closely associated with the long-lasting, repetitive and/or monotonous activities of normal everyday of healthy individuals. It is commonly defined as a state that involves mental and physical tiredness or exhaustion, with a vast range of symptoms including poor concentration, lack of motivation, tired eyes, yawning, and increased blinking. In neuromuscular rehabilitation, mental fatigue of a patient is closely related to effectiveness, usability and attractiveness of the rehabilitation process itself, reflecting possible non-compliance of the end-user, either due to frustrating, exhausting, boring, annoying or error-prone aspects of rehabilitation.The phenomenon of mental fatigue has been addressed by many studies, investigating the association between brain electrical activity using electroencephalography (EEG) and the onset of fatigue symptoms. Although highly attractive and informative, BNCI-based systems are very new and considered unreliable for use in clinical practice. On the other hand, more evident visual signs of mental fatigue, such as tired eyes, yawning, and increased blinking can be robustly detected by video-based monitoring of a person’s face but offer less direct measures of a mental fatigue.qFATIGUE proposes development and validation of a multimodal bio-feedback interface for simultaneous extraction of mental fatigue from video-based and EEG-based monitoring of a person. The main motivation builds on the need for improved understanding and assessment of motivation in rehabilitation patients during their daily exercise and their acceptance or rejection of different reward mechanisms. The proposed information extraction interface will be benchmarked in various ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trafficking pathways of normal and pathologic isoforms of the prion protein' in the context of a Fourth Framework call.

assistant: **Objectives**

The appearance of Bovine Spongiform Encephalopathy (BSE) in Europe and its possible transmission to humans has put a priority on research on transmissible spongiform encephalopathies (TSE). TSE are long known fatal neurodegenerative disorders of humans and animals that are characterized by dementia, motor dysfunction, and cerebral amyloidosis. These disorders are unique because they can be either infectious, genetic or sporadic in origin. All three forms result from a posttranslational alteration in the conformation of a host-encoded membrane glycoprotein called PrPc, which stands for the cellular isoform of the prion protein. Conversion of this normal isoform from an a-helical, readily proteolysed surface protein, to the scrapie isoform of PrP, PrPSc, a highly protease resistant, B-pleated sheet-containing hydrophobic aggregate is not only diagnostic of TSE infection, but is widely taken to be the defining infectious event and source of the subsequent neuropathology. Little is know about PrP which has a central role in TSE as demonstrated by the absolute relationship between PrP expression and development or transmission of TSE. Defining the mechanisms underlying the generation of prpSc from PrPc has now become one of the central issues in understanding the pathogenesis of prion diseases.  It is our contention that the conversion of prion protein from PrPc, to the pathogenic PrPSc, is strongly influenced by, and almost certainly requires, the normal trafficking of prion protein on cells. This perspective has important implications, not only for understanding the basic mechanism of the disease, but also for developing prophylactic and therapeutic measures, and for diagnosis. Despite the intense research interest in TSE, the cellular basis for the pathogenic conversion o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MULTI-SCALE COMPLEX FLUID FLOWS and INTERFACIAL PHENOMENA' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Understanding and controlling of interfacial phenomena in multiphase fluid dynamics remains one of the main challenges at the crossroad of Mathematics, Physics, Chemistry and Engineering. Examples include film flows, spreading and dewetting of (complex) liquids including suspensions, polymer solutions, liquid crystals, colloids and biofluids. Such systems are central for technological advances in the chemical, pharmaceutical, environmental and food industries and are crucial for the development of Microfluidics and Nanostructuring. The level of detail required by multi-scale flows with interfacial phenomena renders full-scale analyses practically impossible. In fact, such approaches often fail to describe even the results of simple experiments. MULTIFLOW will develop low-dimensional models capable of describing complex interfacial flows coupling different time and length scales. Based on the nature of the dominant mechanism, the scientific program will examine three generic classes: from nano- to macroscale, these are dominated by surface forces, reaction-diffusion, and advection. They are also affected by phase transitions, capillarity, chemical reactions, complex rheology and self-structuring. The strength of the network is its integration of all scientific disciplines, technical skills and expertise necessary to support the multi-scale nature of the envisaged research topics. By fostering the mobility and interdisciplinarity of a strong group of early-stage researchers through a set of well-defined objectives and effective networking between different institutions, disciplines and industries, the ultimate goals of this network are: (i) to create a multi-disciplinary, highly innovative and intersectorial training pool in the field of multi-scale interfacial fluid dyna
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Single Atoms Immobilization on MXene-Metal-Organic Polyhedra Assemblies for Selective Reduction of CO2 to Formic Acid' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The EU has set a goal of achieving climate neutrality by 2050 and has implemented an ambitious plan to reduce greenhouse gas emissions, including CO2. The most eco-friendly solutions to tackle global energy and sustainability challenges are electrocatalytic (ECR) and photocatalytic (PCR) CO2 reduction into valuable products. Among the CO2 reduction products, formic acid (HCOOH) has diverse applications as a chemical feedstock, hydrogen storage material, methanol intermediate and fuel cell component. Despite advances in the field, there are still unresolved challenges related to slow electron kinetics, unfavourable product selectivity, and high operating cost. In this respect, single-atom catalysts (SACs) have unique performance due to maximum atom efficiency, unsaturated metal coordination, and the confinement effect, making them a promising solution. However, the efficiency and selectivity of SACs for ECR and PCR to HCOOH are still experimentally scarce. Therefore, tuning the electronic structure of SAC through their immobilization on 2D nanosheets is crucial for designing new catalysts. Accordingly, I plan to prepare novel non-noble metal SA-functionalized MXene-metal-organic polyhedral (MOP) assemblies to replace the state-of-the-art catalysts for efficient CO2 reduction to HCOOH. SA-MXenes can improve electron transport and CO2 capture during ECR and PCR. However, self-stacking of SA-MXene can limit electrolyte access and reduce active site utilization. MOP acts as a spacer to increase porosity and prevent restacking. SA-MXene-MOP, with ligands coordinated SA center will act as a photocatalyst. To ensure the successful implementation of project goals, I will conduct research at IEMN (CNRS & University of Lille) under Dr. Boukherroub's guidance. I expect the research