RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding mechanisms of membrane tension loss and recovery using small-molecule tools' (MEMTOR), addressing dissemination and exploitation.

assistant: **Impact**

Maintenance of membrane tension at the plasma membrane (PM) is an important yet understudied aspect of cellular homeostasis. Dysregulated membrane tension homeostasis has roles in cancer, neurodegeneration, and metabolic syndrome but its study has been limited by a lack of tools to measure and manipulate it. The Target of Rapamycin Complex 2 (TORC2), an important signaling hub regulating cell growth, has an unexpected role in maintaining PM tension homeostasis. A screen for TORC2-specific inhibitors identified the lipophilic molecule palmitoylcarnitine (PalmC) which induces a reversible loss in PM tension. It is currently unknown how PalmC is able to induce this tension loss, but understanding both its mode-of-action and how cells are able to recover from its effects are important for its development as a potential membrane-targeting drug. In this proposal, we aim to reveal key proteins involved in the effects of PalmC (Aim 1). We expect that a specific plasma membrane-localized transporter will mediate its uptake. Both by identifying this protein and solving its structure in a native-like lipidic environment and/or in complex with PalmC, we hope to reveal new insights into how PalmC might be tailored for therapeutic potential.  We will also investigate the recovery process post-PalmC treatment, starting from the observation that the TORC2-activating protein Slm1 co-localizes with TORC2 and forms very large clusters at sites of PalmC-induced membrane invaginations (Aim 2). Previous observations of TORC1 regulation suggest that clustering is correlated with the formation of ordered polymers. To investigate whether this is a conserved mechanism of regulation, we will attempt to isolate a Slm1-TORC2 superstructure and determine its structure using cryoEM with the expectati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel Pesticides for a Sustainable Agriculture' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Members of the oomycete phylum represent highly problematic crop pathogens and a threat for global food security. For instance, P. infestans is the agent of potato late blight, and P. viticola of grapevine downy mildew. Oomycete infections are currently controlled by frequent applications of copper-based compounds, but the massive use of these compounds leads to pollution, residual toxicity and adverse effects on human health. The discovery of innocuous and reliable alternatives to traditional inorganic fungicides remains challenging and has been set as a high priority by EU and other countries. NoPest aims to develop an environmentally friendly approach for crop protection as an alternative to conventional chemical pesticides. The strategy, inspired by medical and pharmaceutical research, relies on peptide aptamers to counteract oomycetes infections by i) identifying small peptides (linear/cyclic peptide aptamers) that inhibit vital enzymes involved in oomycete cell wall formation and cell stability; ii) optimizing aptamer efficiency through peptidomimetics designed for field applications; iii) searching, using chemo-informatics approaches, for non-peptide small molecules that mimic the activity of aptamers.  These objectives will be addressed by selecting peptide aptamers from combinatorial libraries, based on their affinity and specificity for selected protein targets. Key benefits will be i) low probability to select resistant oomycete strains and no risk of co-selection of bacteria resistant to heavy metals; ii) no impact on animal and human health; iii) low environmental impact, as the approach is based on peptides that consist of natural amino-acids; iv) potential to develop additional products that confer antimicrobial resistance to any crop pathogen.  Furthermo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a new flexible manufacturing process for low series production of metal parts, application to custom and special vehicles' (FLEXFORM), addressing dissemination and exploitation.

assistant: **Impact**

The production of special vehicles or products in volumes lower than 2.000 units per year presents specific technical and economical problems with respect to achieving efficiency, reliability and profitability while remaining environmentally friendly. The current trend is an increase of these specific needs which are becoming increasingly unsatisfied mainly due to too high production costs. The special vehicle sector, in which are roughly involved 2.500 SMEs in Europe for a business volume of 4.000 Euros must respond to escalating customer expectations, fluctuating demand, complex supply chain processes, and has now reached a critical point in its development where new solutions are needed in order to stay competitive. The present State-of-the-art is a practically 100% craft or hand-made production. We aim to modify the sector from a current rigid manual manufacture to an innovative, flexible, automated and high added value production, achieving a considerable shift from resource-dependent to knowledge-based manufacturing. The main technological aspect to be developed in order to achieve the project objective is the manufacturing methodology related to the sheet metal components of the vehicle. For this, it is planned to use as starting point an emerging manufacturing technology for sheet metal components, Dieless forming, which is based on incremental deformation and rapid manufacturing technologies. Time reductions of up to 60% in product development and 50% in manufacture as well as a 50% increase in capacity are expected. The SME partners, covering most of Europe's vehicle niche markets will be key to developing applicable knowledge within projects of commercial exploitation in terms of engineering services, together with new developments and the improvement of exis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Anatomically Precise Revolutionary Implant for bone Conserving Osteoarthritis Treatment' (APRICOT) under Horizon 2020.

assistant: **Objectives**

Small joint arthritis presents a large societal burden throughout Europe. The largest pan-European study on osteoarthritis (OA) of the hand observed an average incidence of 16.3%. An ageing population is experiencing OA due to increased levels of obesity, and due to people remaining active later in life, imposing long term loading on their joints. The rise of technology has also increased the incidence of finger joint arthritis in young adults as a result of using electronic hand held devices. People need to be independent later in life and new solutions are required, particularly for small joints, where success rates of artificial joints are very low (revision rates of up to 40% have been reported for finger prostheses). This is because the implants are invasive, sacrifice large amounts of tissue, and most critically, they do not restore the original kinematics of the joint, leading to pain and discomfort due to unnatural loading of the tissues. We aim to develop APRICOT, a novel, extremely thin, self-lubricating compliant implant that is placed between the articulating surfaces of the affected joint. It is minimally invasive, does not remove healthy bone, is suitable for patients of all ages, and does not require the use of general anaesthetics. Successful proof of this radical concept will deliver a revolutionary means of treating small joint arthritis and contribute positively to society as a whole by reducing the burden of pain for millions of sufferers, and by empowering individuals to re-integrate with society with confidence. Small joint reconstruction is predicted to experience the fastest growth globally due to the number of emerging markets and the ageing population. The APRICOT concept therefore represents an opportunity for Europe to penetrate the orthopaed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Baltic biotech science and business forum' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The BALTIC BIOTECH FORUM shall establish a link between the scientific, health care and business community in the biotech/medico field of the Southern Baltic Region. The BALTIC BIOTECH FORUM will be based on the collaboration of BioTechnikum Greifswald and Medicon Valley, both regional initiatives representing the interests of Denmark, Southern Sweden and North-Eastern Germany.By strengthening the transnational relations between scientific/health care organisations and SME's the BALTIC BIOTECH FORUM aims at the development of business- and application driven thematic networks in the field of life science. It also intends to enhance the dissemination and exploitation of results coming out of KA 3 Cell Factory".Conclusions regarding the development of thematic networks, their exploitation and further topics of interest for future actions of the EC shall be drawn in an International Conference at the end of the project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'From oculomotor action to perception'.

assistant: **Innovation**

The proposed scientific project addresses a gap in our current knowledge in neuroscience linking sensory physiology and motor behavior to active perception. Animals disambiguate between motion in the environment and self-movement using corollary discharge, proprioceptive signals and reafferent sensory input. These signals can also be used to influence information acquisition to optimize sensory processing. I plan to explore the links between oculomotor action and perception during proactive exploration of a visual scene to understand how eye movements reshape processing in the early visual system. Because humans are largely ‘visuals animals’ ‘active vision’ is of primary importance to our behavior in our everyday lives. A better knowledge of this phenomenon is relevant to improved understanding of the visual system but will also be relevant to the study of all sensory systems and to a deeper understanding of information processing algorithms, including the value of internal predictive paradigms used throughout the brain. The project has translational potential for the fields of medicine and neural prosthetics, neuromorphic computing, and robotics.This project combines my previous knowledge in cognitive neuroscience and eye movements, acquired during my 6.5 year stay in the USA with the host laboratory’s expertise in low level synaptic system neuroscience. It therefore ensures both acquisition and transfer of new knowledge and opens opportunities of new collaborations. The MSCA Reintegration Fellowship will furthermore give me the opportunity to fully reintegrate in Europe and significantly widen my competences with the ultimate goal of providing the best career possibilities, enhancing the creative and innovative potential, to maximize the contribution of research to th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Surfacing System for Ship Recovery'.

assistant: **Concept**

The propagation of spillages is one of the biggest environmental problems after a ship disaster. Instead of cleaning the dirty areas the SUSY system will avoid the spillages by stabilizing vessels immediately after an accident. The main goal of the project is the development of well known submarine rescue technology into systems usable for merchant ships in emergency situations. The systems for submarines are based on satellite booster technology with liquid or solid fuel to blow water out of the ballast tanks in very short time to provide additional buoyancy to stop e.g. an uncontrolled diving process.Combining this technology with air pressure systems and balloon technology to create a multi purpose modular system for ship rescue purposes is the SuSY project target. Therefore the booster technology combined with pressure air technologies has to be adapted to the salvage procedure requirements. In combination with new balloon textiles a secure vessel stabilisation process as well as the salvage process will be supported.Different application scenarios / concepts can be envisaged: (1) preventive installation of rescue systems on ships with hazardous cargo, (2) equipment for coast guard and rescue squads to quickly stabilize capsized ships and (3) equipment for teams to lift sunken ships.The technical challenges for SUSY where research is needed to develop the envisaged systems are-developing a hydro-dynamical and a thermo-dynamical model as basis for a controlled process for the different possible scenarios-developing a safety and secure buoyancy generating system based on liquid, solid fuel and air pressure,-find the right material to cope with the pressure the temperature and the dynamic loads of a rescue scenario-define a life-cycle cost model to assure the design of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ultra-Fast Silicon Detectors: Enabling Discoveries' (UFSD).

assistant: **Concept**

The goal of our project is to empower a broad range of research fields with a completely new particle detector, able to concurrently deliver time resolutions of the order of ~10 picoseconds and position resolutions of ~30 microns. In so doing, we will remove the constrains that many applications such as particle tracking, medical PET, mass spectroscopy, and beam monitoring have due to the lack of precise information on all 4 dimensions. Our analysis of state-of-the-art particle detectors has shown a dichotomy: specialized sensors measure very accurately either time or position, but not both: the ambitious goal of UFSD is to create a new family of detectors, based on controlled charge multiplication in silicon, which will remove this limitation. We will have to tackle significant challenges along this research path, but our simulations and prototypes indicate that this approach has the potentiality to radically transform present detectors and to enable many applications to reach their peak performances.  Our ultimate goal -- a highly segmented detector with a space resolution of ~30 microns and a time resolution of ~10 picoseconds -- can be achieved only by developing full custom Very Large Scale Integrated chips that, matching the size of the read-out to the area of each pixel sensor, will deliver unprecedented timing resolution at the pixel level.The PI, N. Cartiglia, is well known in the field of particle physics and detector development. He is currently in charge of several projects involving both new directions in physics, among which the LPCC forward physics group and the CT-PPS project at CERN, as well as new developments in instrumentation. He will lead the project leveraging on his past experience in detector development and group/grant management, his knowledge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A breakthrough in biocide technology that combines the potency of two different antimicrobials to obtain unparalleled efficacy.' (SymbiCoat) under Horizon 2020.

assistant: **Objectives**

SymbiCoat is a new surface-bonded biocide that combines the potency of two different types of antimicrobials. SymbiCoat excels in kill kinetics, performance duration and low toxicity and does not induce antimicrobial resistance.  SymbiCoat also allows rapid and easy recharge of the antimicrobial function, saving time and costs as a result that no competing biocide technology could provide. SymbiCoat is able to bring the advantages of the biocide coating technologies to previously inaccessible industries, like the food industry. In fact, thanks to its negligible toxicity and high efficacy, SymbiCoat can be applied to any sensible surface, including food-contact surfaces in the food processing equipment. Thus, SymbiCoat has the potential to radically enhance the contamination control in the food industry, helping prevent the spread of resistant bacteria and foodborne diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A European network for advanced performance studies' (ENAPS), addressing dissemination and exploitation.

assistant: **Impact**

The objective of ENAPS is to establish and test a permanent European network for advanced business process performance studies in European industry.The European Network for Advanced Performance Studies (ENAPS) is intended to be a network established by leading industry and academic partners and agents covering almost all of the countries in the European Union and the European Economic Area. It is mainly limited to three industrial sectors: electronic, aerospace and automotive.The ENAPS project will comprise three major phases:- Network development The objectives are to set up the network by selecting all the appropriate agents and defining the enabling communication technology.- Business process performance requirements The objectives are to select methods and measures for business process performance, to make the network operational.- Test operation The objectives are to specify a knowledge transfer package and to develop a set of demonstrators. In addition, the ENAPS project will include project management and project exploitation. The aim of the network is to utilize the competence and expertise in selected European industries and academic institutions for the benefit of all European industry. Performance studies, education and industrial projects are meant to stimulate performance in the enterprises and to improve their competitiveness. The network will involve larger companies, but should aim at technology transfer towards small and medium sized enterprises (SMEs). When the network is established it will provide a vehicle for the European industry to do performance studies at a micro level. The studies will focus on business process best practices in the participating enterprises. By means of telecommunication, best practice experience and data will be exchanged be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Synthesis of Smart Virus-like Hierarchical Structures Based-on Polymer-Peptide Conjugates and the Potential Application in Drug Delivery' (SMARTSTRUCTURES).

assistant: **Concept**

In this proposal, we intend to combine the advantages of virus and polymersome structural motifs into one integrated model as a promising strategy to construct hybrid structures that are efficient delivery vehicles. First, folic acid-modified polyN-(2-hydroxypropyl)methacrylamide-poly(L-cysteine) conjugate (FA-PHPMA-b-PLC) will be synthesized. The biocompatible PHPMA is used as the hydrophilic part, and PLC is chosen for its ability to aggregate in water (by either hydrogen or covalent bonding via beta-sheet formation or disulphide linkage). Not only do the thiol groups in PLC chain play an important role for covalent loading of drugs/proteins/genes via thiol exchange with disulfide groups, but also the oxidation of the cysteine residues to form intra- and intermolecular disulfide bridges further stabilize the polymersome structure. After forming the polymersome, the biomolecules will be incorporated by either covalent or noncovalent mechanisms. Finally, zinc oxide nanoparticles modified by disulfide-linked pyridine will be covalently encapsulated into the PLC shell to obtain the hybrid virus-like structure with ZnO nanoparticles as a key component of the coronal layer. We anticipate that the constructed hybrid structure will enter the target cell by endocytosis. The low pH in the endosome (pH~5) will then accelerate the dissolution of the ZnO nanoparticles and release the biomolecules. Subsequently, glutathione in the cytoplasm will reduce the cross-linked disulfides in PLC shell and lead to the disassembly of the polymersome. Therefore, as a new hybrid structure that integrates significant advantages of both the polymersome and virus models of biomolecule delivery, it is reasonable to believe that it will provide a new advance for the design of delivery vehicles for t