RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Cell Biology of Remyelination' (ReMyelin), addressing dissemination and exploitation.

assistant: **Impact**

The failure of the endogenous regenerative process – remyelination - in chronic Multiple Sclerosis (MS) lesions leaves axons denuded of myelin and contributes to the neurodegeneration that underlies the progressive disability associated with the disease. Stimulating effective remyelination is therefore a key goal for regenerative medicine. Neuropathological studies in humans and animal models have shown that remyelination results in short, thin myelin sheaths. predicted to be less efficient at accelerating conduction and providing axonal metabolic support - two key functions of the myelin sheath. To this end, this project (ReMyelin) examines intrinsic and extrinsic mechanisms that might explain these short, thin sheaths. We propose that they result from a combination of altered intrinsic and extrinsic pathways affecting the myelination process. Intrinsic pathways will be revealed by an innovative three-dimensional culture system using artificial axons developed in the laboratory of the host investigator, enabling changes associating with ageing to be revealed, whilst extrinsic pathways will be revealed using a genetic approach that allows the visualization of newly-generated myelin-forming cells (oligodendrocytes) and their myelin sheaths in demyelinated lesions of mice. These studies on the extrinsic pathway will focus on the role of axonal activity, using chemogenetics to activate or inhibit axonal activity focally and rehabilitation to activate the system more globally. Together these experimental approaches will identify the causes for altered sheath geometry in remyelination, with these new discoveries then underpinning future studies targeting these pathways so as to enhance remyelination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Oral bacteria as determinants for respiratory health' in the context of a Horizon 2020 call.

assistant: **Objectives**

The oral cavity is the gateway to the lower respiratory tract, and oral bacteria are likely to play a role in lung health. This may be the case for pathogens as well as commensal bacteria and the balance between species. The oral bacterial community of patients with periodontitis is dominated by gram-negative bacteria and a higher lipopolysaccharide (LPS) activity than in healthy microbiota. Furthermore, bacteria with especially potent pro-inflammatory LPS have been shown to be more common in the lungs of asthmatic than in healthy individuals. The working hypothesis of BRuSH is that microbiome communities dominated by LPS-producing bacteria which induce a particularly strong pro-inflammatory immune response in the host, will have a negative effect on respiratory health. I will test this hypothesis in two longitudinally designed population-based lung health studies. I aim to identify whether specific bacterial composition and types of LPS producing bacteria in oral and dust samples predict lung function and respiratory health over time; and if the different types of LPS-producing bacteria affect LPS in saliva saliva and dust. BRuSH will apply functional genome annotation that can assign biological significance to raw bacterial DNA sequences. With this bioinformatics tool I will cluster microbiome data into various LPS-producers: bacteria with LPS with strong inflammatory effects and others with weak- or antagonistic effects. The epidemiological studies will be supported by mice-models of asthma and cell assays of human bronchial epithelial cells, by exposing mice and bronchial cells to chemically synthesized Lipid A (the component that drive the LPS-induced immune responses) of various potency. The goal of BRuSH is to prove a causal relationship between oral microbiome a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of chromatin-modifying enzymes in oligodendrocyte precursor state in development and multiple sclerosis' in the context of a Seventh Framework call.

assistant: **Objectives**

Oligodendrocytes (OL) are glial cells that mediate myelination of neurons, a process which is defective in multiple sclerosis (MS). Although OL precursors can initially promote remyelination in MS, this process eventually fails. OL precursors (OPCs) go through several epigenetic states during development and MS, which ultimately define their potential to differentiate and myelinate. Transcription factors such as Sox2, Sox10 and Sox9 are key regulators of OL development. However, it is unclear which are their transcriptional mechanisms of action and whether they recruit epigenetic modulators such as chromatin-modifying enzymes (ChMs). In this project, the main objectives are:1) COMPARATIVE QUANTITATIVE PROTEOMICS OF TRANSCRIPTION FACTOR COMPLEXESWe will generate a novel comprehensive library of OPCs representing different epigenetic states during OL development and animal models of MS. We will identify proteins that interact with the transcription factors Sox2, Sox9 and Sox10 in epigenetically distinct OPC populations using SILAC technology, coupled with antibody-based or biotin-based affinity purification strategies and Mass Spectrometry.2) IDENTIFICATION OF CHROMATIN SIGNATURES AND MOLECULAR MECHANISMS THAT DEFINE EPIGENETIC STATES AND CELL POTENTIAL IN OPCsTo determine if  the expression/activity of the identified ChMs account for the variation on the differentiation potential of distinct OPCs, we will perform overexpression and RNAi-based screens. In order to assess how the enzymatic activities of the identified proteins modulate OL genes in different OPCs, we will investigate the genome-wide occupancy in OPCs of the identified chromatin-modifiers and associated histone modifications, by Chromatin Immunoprecipitation followed by Next Generation Sequencing.This projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'AntibioDx: A groundbreaking in vitro diagnostic device with a billion-dollar sales potential' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

When diagnosing bloodstream infection (BSI), 19th century blood culture is essentially still the gold standard method - despite the highly critical 1-2 days delay from sample to result. Many cases of BSI remain undertreated in the early and highly critical stage of the infection and patients risk sepsis, which is among the 10 most common causes of death in hospitals and the most expensive condition to treat. AntibioDx is a device that will deliver the diagnostic capability needed in 21st century healthcare for preventing sepsis and reducing healthcare cost. It will provide doctors with information about the specific pathogen causing BSI and its antimicrobial-resistance profile within 1 hour. Personalised treatment with the most effective antimicrobial will replace empirical treatment using broad-spectrum antibiotics. Lives and money will be saved and the growing problem with resistance to antibiotics will be reduced.AntibioDx is a game changer with obvious gold standard and large sales potential. The clinical performance of the device is unrivalled and the possibility of using it with existing laboratory hardware facilitates full commercialisation in a market valued at 1 billion USD annually.Experienced clinicians have greeted the AntibioDx device with strong interest but final clinical validation studies is needed for taking significant commercial steps and realising full sales potential.The purpose of this Phase I application is to fully demonstrate proof-of-business and prepare the device for clinical validation as foundation for FDA approval. This work will be undertaken in collaboration with expert partners, including internationally renowned university hospitals in the EU and US.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Short-term rentals and housing financialisation. Evidence and policy innovation'.

assistant: **Concept**

The success of digital platforms such as Airbnb and the subsequent proliferation of short-term rentals in cities have caused many challenges for local authorities, especially regarding the regulation and mitigation of their social impacts. Current attempts to regulate short-term rentals assume that Airbnb and similar providers are part of the so-called ‘sharing economy’ in which hosts would occasionally share their homes with visitors. However, there is increased evidence that short-term rentals have become professionalised, and that individual and corporate investors have started to channel substantial investment into this market. In this regard, POLIS explores the links between short-term rentals and housing financialisation and, in doing so, will provide innovative understandings of the Airbnb-led restructuring of local housing markets. POLIS draws on the principles of evidence-based policy making with the aim of advancing policy innovation for the regulation of this emerging economic sector. In particular, POLIS will address three research objectives: it will (i) examine the professionalisation of the short-term rental market; (ii) investigate to what extent Airbnb channels financial investment into the housing market; (iii) elaborate alternative policy proposals for positive change. POLIS is a gender-sensitive project and has an intrinsic gender dimension in all phases of the research. The project will explore the cases of two European cities: Lisbon and Leipzig. It will provide comparative insights into a topic that has proved to be of significant political, economic and spatial relevance. Research objectives will be addressed using a mixed-method design that collects and analyses data from a variety of sources, especially in-depth interviews and critical policy a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'International Conference on Airports, October 2009 Paris'.

assistant: **Innovation**

Concept: The Air and Space Academy (AAE) proposes to organise a 2-day international conference on “Airports and their Challenges”, in DGAC Paris (7-8 October 2009).  Background: Europe needs to develop new transport networks and infrastructures in order to support its industry and promote economic growth. Air transport has increased faster than any other mode of transport in the past 20 years, but concerns linked to traffic saturation and the environment are growing. Airports are an essential element in the air transport system and yet their development can give rise to tension and even conflict between the different economic and political players.  Reflection is needed on how to guarantee sufficient airport capacity in the enlarged European Union whilst respecting the different constraints of safety, security, environment, customer satisfaction, intermodality, etc. Objectives: This conference will aim to achieve a broad, dynamic vision of the evolution of airports in Europe and worldwide, of the different challenges and constraints facing them within a 15-20 year timeframe and to define the orientations necessary for the future. It will do so by bringing together top policy makers and operators from the European and international air transport system to pool information, discuss current developments and share new innovative ideas.  Guidelines defined at this conference will be disseminated widely to policymakers worldwide in order to maximise impact. Organisation: AAE has a wide experience of organising successful conferences. A Programme Committee, chaired by Marc Noyelle (former Executive Director Development and facilities for Aéroports de Paris, and Administrator-President of ADPI international engineering branch), will comprise experts from AAE, DGAC, Air France-K
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'A sense of direction: cooperative behaviour and chemotaxis in the life cycle of Trypanosoma brucei'.

assistant: **Concept**

Many protozoan parasites have complex life cycles requiring migration through different organs in their hosts. The current mind-set is that parasites act as individuals and that tissue specificity is largely dictated by receptor-ligand interactions between pathogen and host surface molecules. However, parasites are more autonomous and manipulative than we give them credit for. I propose that self-steering, a mechanism by which groups of cells migrate in response to gradients that they create and/or modify, is central to their ability to orient themselves and home into host tissues.Trypanosoma brucei, which causes sleeping sickness, cycles between mammals and tsetse flies. Trypanosomes lack G-protein coupled receptors (GPCR) and heterotrimeric G proteins, which act as sensors and signal transducers in yeast and multicellular eukaryotes, but encode a large number of receptor adenylate cyclases. We recently discovered that trypanosomes generate pH gradients on semi-solid surfaces and use cyclic AMP (cAMP) signalling to move collectively in response to them. This correlates with their ability to cross barriers and sequentially colonise organs in tsetse flies. Our newest findings that trypanosomes respond chemotactically to other metabolites, together with evidence from several laboratories that T. brucei is not restricted to the blood and central nervous system in mammals, but also invades other organs, are the focus of this project.My objectives are: •to elucidate the intracellular mechanism of cAMP-mediated pH sensing •to explore other cues for chemotaxis and determine how signals are transduced  •to establish whether the expanded family of adenylate cyclase genes in T. brucei plays a role in extravasation and colonisation of different organs in mammalian hosts.This is th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advances in Spectroscopic Monitoring of Styrene Emulsion Polymerization' to be submitted under Seventh Framework.

assistant: **Abstract**

This project proposes further advancement and development of the novel spectroscopic method i.e. of its current state of the art, created during Marie Curie ITN research project INTROSPECT. Although it promises a noticeable breakthrough in Process Analytical Technology (PAT) of monitoring concentrations in particulate/turbid media it is in an embryonic stage and its practical applicability is yet unanswered question. A number of applicability issues must be solved for its successful implementation in a particular industrial process.The focus of this project is the application of this method to styrene emulsion polymerization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A Semantic Foundation for Persistent Programming' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Non-volatile memory (NVM) is an emerging technology that provides orders of magnitude faster access to persistent storage (which preserves its contents after a crash or a power failure) than hard disks. While NVM is expected to radically change how we manage storage in applications, its programming model is standing on very shaky foundations.The persistency semantics of the mainstream architectures is very unclear and full of counterintuitive behaviours. As a result, writing correct NVM programs is extremely difficult: there is no support for persistent programming in programming languages nor any techniques for testing and verifying their correct recovery from crashes.PERSIST will develop a solid mathematical basis for determining the possible outcomes of persistent programs and reasoning about their correctness. More specifically, it will produce:(1) formal empirically-validated persistency models for mainstream hardware architectures,(2) formal efficient persistency models for mainstream programming languages,(3) firmly-grounded higher-level abstractions to ease persistent programming, and(4) the first effective testing and verification techniques for persistent programs.


**Keywords:** semantics of programming languages, verification, non-volatile memory, weak memory consistency, persistent memory,  concurrency, program logic, model checking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Standardisation project for optical techniques of strain measurement' (SPOTS).

assistant: **Concept**

Prenormative research in the area of strain measurement using optical techniques is proposed. These techniques use a non-contacting approach to the assessment of engineering artifacts subject to in-service loading. The resultant comprehensive stress data allows lighter, stronger, more reliable and safer products to be designed with more certainty. Recent progress in computer processing and chip-mounted sensors has led to rapid advances in optical metrology. The project addresses the lack of standards and reference materials that are necessary for the full benefit of the new technology to be realized. The project is outputs will be optimized methodologies; physical and virtual reference materials; and recommended routes for traceability. A unified approach to a range of optical techniques will be taken with partners both from across the innovation process and from a number of major industries including aerospace, automotive and microelectronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of regions in the European Bioeconomy - Bratislava Bioeconomy Conference 2016' (BBEC2016).

assistant: **Innovation**

The main objective of the project is to organize  the international conference “Bratislava Bioeconomy Conference 2016” during the presidency of the Slovak Republic in the second half of 2016, disseminate its outcomes and to prepare the discussions for the Agriculture and Competitiveness Council meetings based on the outcomes of the conference. The aim of the conference is to discuss with national and regional stakeholders the new bioeconomy context for the agriculture, forestry and fisheries, the role of research and innovation to overcome the big societal challenges ahead of us and also to identify the barriers in the regions in adapting the bioeconomy strategy. The proposed Slovak Presidency “2016 Bratislava Bioeconomy conference” will provide an occasion to have high-level discussions on sustainable bioeconomy, strategies and actions. The aim is to create a programme that will provide a forum for stakeholder across the whole bioeconomy value chain to discuss the progress of the bioeconomy. The conference will not provide just a summary of the current state of matters, but will be forward looking by creating new policy ideas, catalysing joint initiatives and research and searching synergies among existing actions, projects and initiatives. The programme will be carried by top-level speakers from various fields, academia, and business and the concept and first draft of the conference programme was created by group of national and international experts, representatives of stakeholders and representatives of public institutions. Attention will be paid to post conference activities including policy seminars and policy briefings in order to achieve better implementation of the bioeconomy strategy in European regions.


**Keywords:** sustainable production, renewable resour