RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular mechanisms monitoring sex determination in Arabidopsis thaliana' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In higher plants, sex determination is usually controlled by the genotype and they can be modified by various environmental factors and/or by hormones present in the plant. The mechanism by which this process is controlled in plants is still poorly understood.In melon, sex determination is governed by the identity of two genes, andromonoecious (a) and gynoecious (g). The gene a encodes for an ethylene biosynthesis enzyme, CmACS-7, that repress stamen development in female flowers. The g gene encodes for a transcription factor, CmWIP1. CmWIP1 represses indirectly CmACS-7 expression to allow stamen development. The model suggests that the two genes interact to control the development of male, female and hermaphrodite flowers.CmWIP1 gene encodes for a nuclear protein that is conserved throughout the plant kingdom and defines a new subfamily of plant zinc finger proteins. In Arabidopsis thaliana genome 6 WIPs have been identified. However, none of the WIP proteins has been functionally characterised.The goal of this proposal is to study the expression and regulation of WIP proteins in A. thaliana. We will use as a starting point the information obtained from the sequence analysis of CmWIP1 in melon to understand if the function of this protein is conserved between melon and A. thaliana. Preliminary experiments shown that ectopic expression of the CmWIP1 gene can determine the sex of A. thaliana plants. Using a combination of genetic and genomic approaches, more easily implemented in the model plant A. thaliana, we will study the involvement of WIP proteins in plant sex determinism and development. The finding and the concepts that will be gathered on the A. thaliana model system will be transferred to melon at later stage of the project. Understanding how different sexual s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Demography of Sustainable Human Wellbeing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This project will apply two distinctly demographic concepts to research questions that go far beyond demography. The wellbeing indicators proposed here will be based on life table methods and the recently operationalized concept of Demographic Metabolism – modelling social change through the replacement of generations – will be used to get a quantitative analytical handle on the temporal dynamics of improving human wellbeing. The project will theoretically develop, empirically estimate, test and forecast indicators of human wellbeing that are based on life table methods and hence reflect the basic – but often overlooked fact – that being alive is a necessary prerequisite for enjoying any quality of life. But since mere survival is not sufficient as an ultimate goal for most people the person years lived at each age will be weighted with four different dimensions of empowerment: health, literacy, happiness and being out of poverty. These are four dimensions of an indicator tentatively called ELY (Empowered Life Years). ELY will also serve as the explanandum of a global level econometric estimation of the determinants of wellbeing considering human, manufactured and natural capitals as well as knowledge and institutions.The global level analysis is complemented by a set of strategically chosen in-depth systems-analytical case studies in Namibia/Western Cape, Nepal, Costa Rica and historical Finland modelling the population-development-environment (PDE) interactions including feed-backs e.g. from environmental degradation to wellbeing and taking the trends of ELY in different sub-populations as sustainability criteria. They will also include stake holder involvement and science-policy interactions.This innovative inter-disciplinary cross-fertilisation can potentially make
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'EURExpress, a European consortium to generate a web-based gene expression atlas by RNA in situ hybridization'.

assistant: **Innovation**

This EURExpress integrated project responds to the priority topic Global in site gene expressions analysis in rodent models and human tissues". EURExpress integrates European skills, efforts, resources and information in the field of systematic gene expression analysis. Expression data of > 20,000 genes will be generated by RNA in site hybridisation (ISH) on E14.5 wild type marine embryos which will result in detailed description (at a cellular level) of gene expression patterns. A "transcriptome atlas" will be generated using a newly developed automated RNA ISH system. Automated scanning microscopes will collect image data which will be electronically sent out in a digital format for annotation. The latter will be performed using a web-based "virtual" microscope and entered in a hierarchical database designed to hold large amounts of image data and display them in a user-friendly format. For a subset of genes, mainly those directly involved in human diseases, expression data will also be generated by using human and murine tissue arrays. This will offer the opportunity to compare human and mouse expression patterns in adult tissues. This project builds a strong European concentration of skills in gene expression analysis and mouse geneomics. It will allow integration with existing European Projects, such as mouse mutagenesis and mouse phenotyping projects, which critically depend on detailed information on gene expression patterns. Integration of the efforts of several European laboratories will result in the standardization of methods to generate, collect and display gene expression data. Furthermore, technological expertise will be disseminated by training and exchange programs. All expression data will be made readily available to the scientific community via the EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'UNderstanding Lipid ImmunoMetabolIsm To trEat Disease' in the context of a Horizon Europe call.

assistant: **Objectives**

The UNLIMITED project addresses the critical challenges of lipid immunometabolism, a rapidly emerging field with transformative potential for treating immune-mediated diseases such as cancer, autoimmunity and metabolic disorders. Lipid metabolism has been recently recognized as a regulator of immune cell function, yet the intricate interactions between lipid pathways and immune responses within tissue-specific microenvironments remain poorly understood. This knowledge gap hampers the development of precision therapies tailored to the metabolic needs of immune cells in diverse tissue niches. To tackle these challenges, UNLIMITED will train 15 Doctoral Candidates in cutting-edge interdisciplinary research, equipping them with expertise spanning immunology, bioinformatics, metabolism, and drug development. A key feature of UNLIMITED training programme is the integration of leading-edge methodologies, such as multi-omics machine learning, single-cell technologies, CRISPR-Cas9, and spatial metabolomics, alongside groundbreaking techniques pioneered by consortium partners, including SCENITH, Met-Flow, click-chemistry, LIPSTIC, and advanced lipidomics. UNLIMITED’s training program emphasizes a holistic, interdisciplinary approach, providing DCs with technical skills, unparalleled expertise, and transferable competencies to thrive in academic and industrial sectors. The project will unlock unprecedented insights into how lipid metabolic pathways regulate immune cell function and adapt to changes in the tissue microenvironment. This knowledge will enable the identification of novel therapeutic targets and pioneering precision therapies for immune-related diseases. This bold initiative strengthens Europe’s leadership in health innovation, creating a new generation of highly skill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Highlights in Microtechnology' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The continuous progress in micro and nano-system technologies has allowed the successful development of many innovative products in process control, environmental monitoring, healthcare, automotive and aerospace as well as information processing systems.In the training course Highlights in Microtechnology" (HIM) an overview will be given of modern micromachining applied to the realization of miniaturized systems. The events foresee a common core on the fundamentals of microtechnology, high-resolution microscopy, microsystems, microrobotics, UV-photolithography for microstructuration, micromolding and hot embossing.We then present the general tools for microtechnology and their different hot fields of application as life sciences, satellite communication, MEMS for spatial applications and micro-optics and metrology. The structure of the course foresees 10 intensive days on relevant topics at the heart of microtechnology including lectures and hands-on experiences in clean-rooms and laboratory.The topics o f the laboratory sessions are High resolution microscopy: AFM, ESEM, TEM, Image processing, Hands-on optical MEMS, Micro-optical components. Visits to high-tech companies are the agenda. Two keynote speakers will give a lecture during each course. A permanent e-forum will be established.It will be open to all the participants, trainers and committee members in order to generate a durable networking related to scientific and technological questions in microtechnology. We propose a series of four events to b e held one a year in the region of Neuchâtel (CH) and Franche-Comté (F) at the heart of microtechnology.We believe that there is an increasing need of education to be satisfied in the field of microtechnology. In particular, young scientists who seize the opportunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Evolutionary Determinants of Influenza Virus Pathogenesis and Tissue Tropism'.

assistant: **Concept**

Influenza A virus bears high morbidity and mortality burdens in humans following yearly seasonal epidemics and occasional yet potentially devastating pandemics. These burdens are a result of disease severity following infection in individual hosts, and the size of influenza epidemics/pandemics at the population level. The relationships and feedbacks between influenza virus pathogenesis at the individual host level and influenza virus epidemiology at the population level are ill understood. Influenza virus tissue tropism contributes to determining which regions of the respiratory tract (from nasal cavity to deep lungs) are infected. The spatial location of influenza virus infection along the human respiratory tract is a determinant of the virus’ pathogenicity and transmissibility. While disease severity increases deeper down the respiratory tract, transmissibility appears favoured higher up. Both pathogenicity and transmissibility, associated with tissue tropism, contribute to the virus reproductive fitness, defining the size of the epidemic or pandemic. Therefore, strong selective pressures acting within hosts and at the population level likely shape tissue tropism to maximize influenza virus reproductive fitness. The aim of the project is to characterize these selective pressures and their interplay at the interface of within- and between-host dynamics, by combining experimental work and mathematical modelling. Key objectives are to determine the selective pressures associated with transmission and pre-existing immunity on influenza virus tissue tropism in an experimental setting; and determine the mutual interactions of these selective pressures by use of combined within- and between-host mathematical models. Modelling skills and knowledge will be transferred by the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel biomaterials to prevent dental peri-implant infections' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Peri-implant infections are a devastating complication of dental implants, occurring in approximately 20% of all patients, that can ultimately lead to implant instability and loss. Considering this high prevalence rate and the lack of predictive treatments in severe cases, prevention of peri-implantitis has become a major challenge in clinical dentistry.NOMAD will develop innovative biomaterial approaches for dental implants, from TRL3 to TRL5. Various functionalised implant coatings for titanium and zirconia implant surfaces will reduce the risk of infection (and associated inflammation), improve soft-tissue sealing at the gum line, and promote osseointegration. A further innovation are multi-material crowns and abutments using additive manufacturing combined with grafting of nanotubes, enabling controlled release of prebiotic as well as antimicrobial compounds in response to bacterial adhesion at the onset of infection (i.e. smart conditional release). A combination of these approaches will be employed in the final product to provide a customisable, all-round solution focusing on crown, abutment and/or fixture for prevention of peri-implantitis.Advanced in vitro testing using complex cell co-cultures in bioreactor systems, and biomechanical stability tests will enable selecting the most promising biomaterials for testing in relevant in vivo models. These results will enable rapid progression to first-in-human studies of new biomaterials after the project. A cost-benefit and regulatory analysis will be performed and an innovation management strategy will develop a roadmap for commercialisation. The NOMAD consortium includes a major dental implant manufacturer, academic groups, SMEs working on biomaterials innovation and a specialist innovation company. The project is a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Contribution of neurogliaform cells to signal flow in the barrel cortex during whisking behaviour' (2007-2013).

assistant: **Innovation**

The barrel cortex is the part of rodent primary somatosensory cortex which is responsible for the tactile representation of whiskers. It is recognized as a key model system for understanding fundamental aspects of active sensory processing and more generally investigations into this cortical area have already provided a large amount of information about the basic architecture of cortical microcircuits.A considerable amount of information has been gathered about barrel cortex microcircuits from in vitro brain slice experiments, which forms a basis for understanding the differential roles of the various classes of excitatory and inhibitory neurons. However, we know much less about how these cells function in awake behaving animals. Recent improvements of the whole-cell patch-clamp recording technique make it possible to record from neurons in the cerebral cortex of anaesthetized and awake animalsNeurogliaform cells appear to play a unique role in cortical microcircuits. A single firing of a neurogliaform cell can activate both postsynaptic and presynaptic GABA-B and extrasynaptic GABA-A receptors residing outside the synaptic clefts. This gives to these cells the capacitiy of evoking long lasting inhibition of dendritic origin in the overwhelming majority of neighbouring neurons, besides the capacity of suppressing overall synaptic transmission in vicinity of them.My first research objective is to carry out dual in vivo whole-cell patch-clamp recordings from identified neurogliaform cells and from other neighbouring cells in layer 2/3 of barrel cortex of awake behaving animals and subsequently in order to investigate the consequences of synchronized activity of neighbouring neurogliaform cells on the operation of barrel cortex microcircuits, My second research objective i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The First European Platform for Accesible Paper Vote Cast' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Despite the available technology already used for data security and verification, for instance in online banking and airport controls, such implementation has not yet reached the voting process. Therefore, the current process, based on paper ballot in the polling place, remains mainly the same since its inception before 1900. In general, the voting process starts with identity verification in the polling places and afterwards the ballot is filled, cast and counted or either delivered to a counting place. This process has been reported to imply serious difficulties for disabled voters (80 million in EU) and EU citizens who live in an EU Member State other than their original country (13.6 million). Both collectives face tedious bureaucratic preliminary request for voting or physical constrains to reach the voting place. The problem is getting evident as the number of citizens living out of their own country is grown globally at a compound annual rate of 2,4% and by 2017, will reach around 56,8 million. In addition to the difficulties faced by disabled and out-of-country voters, the current voting process costs entirely too much tax-payer money and environment impact due to the paper use. According to a recent UN report about electoral costs, the current global annual expenses for election execution reach around 9,5 billion euro.AccessVote offers the first online platform for the European countries that generates the paper vote at the voter place to be sent by post or at the polling place. Our solution is formed by an online platform that enables the voting cast through a high secure, remote and accessible interface overcoming the legal barriers typically associated with e-voting, since the traditional paper vote for vote-casting and counting is still use. Thus, our syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Effects of hydrological changes on coastal ecosystems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Groundwater dynamics and water table level can greatly influence the physiological performance of plant species, composition of vegetation and ecosystem productivity. Understanding ecosystem sensitivity to hydrological changes such as groundwater decline, and the ecophysiological processes involved, are important challenges. This is particularly relevant in seasonally dry semi-arid coastal dune ecosystems of the Iberian Peninsula, where the human pressure is currently high, exacerbating climatic trends of groundwater scarcity. Community-level assessments and integrated trait syndromes that can point out vegetation vulnerability to the reduction of groundwater resources are greatly needed. Thus, this study aims to evaluate the effects of hydrological drought, particularly water table lowering, on semi-arid coastal dune ecosystems, and define their vulnerability to groundwater limitation, helping to mitigate the impact of water-resources’ changes on relevant coastal ecosystems. The project will be based on physiological measures, manipulative approaches, functional diversity, vegetation structure, remote sensing, water-table depth modeling, up-scaling processes and assessment of integrated vegetation responses to groundwater changes. Through a multi-level (plant to ecosystem), cross-scale (local to regional) approach, I will define suitable indicators of the impact of groundwater changes on coastal dune ecosystems and map their vulnerability to hydrological droughts. The outputs of the project will have great implications for water-management plans, by signaling vulnerable and endangered coastal areas to current and future groundwater changes. Ultimately, it will contribute to better outline sustainable management strategies conciliating habitat conservation and water-res