RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Gene transfer in skin equivalnts and stem cells: novel strategies for chronic ulcer repair and tissue regeneration' in the context of a Sixth Framework call.

assistant: **Objectives**

Chronic ulcers and defective tissue repair represent a major health problem. Conventional therapeutic approaches are not sufficient to guarantee an adequate healing in chronic ulcers and recurrence is frequent. Among non conventional treatments, short p rotein half-life and inefficient delivery to target cells have been identified as main limitations of the topical application of recombinant growth factors. Similarly, the therapeutic effect of skin equivalent grafting was limited, in particular due to impaired production of granulation tissue by the host. The present project relays on the development and validation of novel therapeutic strategies for tissue regeneration, based on the use of genetically modified stem cells and skin equivalents. Th e plan structure starts with a multidisciplinary research approach aimed at characterising the role and mechanism of action of potentially therapeutic proteins. In parallel, a wide analysis will be conducted to exploit the most suitable adeno and adeno -associated viral vectors for gene transfer into selected cell types. The research will be then directed towards in-vivo application of genetically modified stem cells and ex-vivo engineered skin equivalents as delivery systems of therapeutic proteins. Safety and potential therapeutic effect will be tested on diabetic animals and/or other animal models of impaired wound healing. Optimized procedures for ex-vivo genetic modification of skin equivalents using adeno and/or adeno-associated viral vecto rs carrying genes with demonstrated therapeutic potential will be translated into Standard Operating Procedures (SOPs) to produce skin grafts for clinical use. The research will ultimately target the design of a Phase I clinical trial protocol for gene therapy of chronic diabetic ulcer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Radioactivity Monitoring in Ocean Ecosystems'.

assistant: **Concept**

Natural radioactivity in the marine environment has been present since the Earth’s formation, while artificial radionuclides were introduced into the oceans in 1944. More recent direct sources exist that feed the oceans, such as low-level liquid discharges from reprocessing plants, large-scale releases due to disasters (e.g. Fukushima hit by the tsunami in 2011), and smaller-scale radiological events. Exploration of submarine environments should consider the existence of radioactivity in terms of its short- and long-term impact on marine and coastal ecosystems, also in correlation to natural hazards, such as seismic activity over submarine faults. Significantly undersampled in oceans, radioactivity poses real risks to marine ecosystems and human population, urging for detailed, data-driven modelling.RAMONES aims to offer new and efficient solutions for in situ, continuous, long-term monitoring of radioactivity in harsh subsea environments. A new generation of submarine radiation-sensing instruments, assisted by SoA robotic and artificial intelligence (AI) will be developed towards understanding radiation related risks near and far from coastal areas, while providing data towards shaping new policies and guidelines for environmental sustainability, economic growth and human health.The main ambition is to lay a radical new path to close the existing marine radioactivity under-sampling gap and foster new interdisciplinary research in threatened natural deep-sea ecosystems. RAMONES will invest a significant effort to provide tools for long-term, rapid deployments, propose new AI-driven and supported methodologies, and offer scaled-up solutions to researchers, policy makers and communities. RAMONES will combine SoA equipment from various disciplines and advanced modelling in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High-throughput drug screening for identifying personalized cancer treatments tailored to the particular mutations of the patient’s tumor'.

assistant: **Innovation**

Cancer is caused by a series of genetic alterations that confer an advantage to cancer cells, leading to uncontrolled growth. However, each tumor exhibits distinct molecular changes, making each patient’s malignancy unique. Hence, in the personalized medicine era, cancer treatment aims to tailor the most suitable treatment for each patient according to his/her genetic background, tumor acquired mutations and clinical indications.The p53 tumor suppressor is the most frequently mutated gene in human cancers, with thousands of different tumor-associated mutations reported. Many such cancer-associated mutations in p53 lead to loss of its tumor suppressive activity and in some cases, to gain of new oncogenic functions, resulting in tumor recurrence and enhanced patient mortality. Importantly, tumors with different p53 mutations exhibit specific cancerous phenotypes and do not respond to particular treatments.Based on our ERC-funded breakthrough technology, where we made a library of ~10,000 distinct p53 variants, and based on our strong IPR offering and competitive advantages, here we propose to develop three products for determining which treatment (or combination) would be most effective for treating a patient’s tumor according to his specific p53 sequence, reducing excruciating side effects and improving treatment outcomes:1) Offering patients/physicians a list of treatments ranked by their efficacy in treating cells of similar origin and p53 mutations to those present in the patient’s tumor, allowing them to make more informed treatment decisions.2) Offering companies in the personalized cancer treatment field access to our existing proprietary data regarding treatment efficacies towards p53 genetic variants.3) A service to drug developing companies that applies our tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Study of electrostatics related problems in industry' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

This project attains the exploratory phase (stage 1) aimed at verifying the possibility of forming a thematic network (8-9 industrial and university partners) to deal with electrostatic related problems encountered in industry. Electrostatics is a transversal subject: it concerns several and different secotrs of indsutry. In certain cases, solutions to some electrostatics related problems exists in an industrial sector, which are not known in other sectors. Goal 1) A database containing all the difficult-to-be-retrieved information (national standards, industrial codes-of-practise, reports, etc.) is needed to help solving the above intercommunication problem (which is hard to overcome, especially for SMEs) : the proposed network would rig such a database and make it accessible to the public. Goal 2) Cases are known of interlaboratory internationalcomparisons of surface resistivity measurements whose results differ by as much as 3 orders of magnitude. This fact affects the trade of goods (e.g. floors, carpets, electronic apparatus, etc.) within the Community and outwards. The proposed network will organise a Round Robin test among its laboratories to reach a common protocol and to avoid, within the European Union, the named large difference in the results of surface resistivity measurements. Goal 3) There are 'models' (HBM, CDM, etc) in the presently available standards, to simulate electrostatically dangerous situations, whose application can cause evaluation errors. The proposed network will study the problem and elaborate strategies to solve it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid Performance Assessment of Sand Mitigation Measures', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Civil structures and infrastructures in desert environments and sandy coastal regions are sensitive to windblown sand. Even if the problem was first tackled in the fifties, it has emerged as a key scientific, technical and economic issue in the last decade. Indeed, windblown sand effects can lead to several incremental costs in infrastructure management, and also disastrous events.The demand for the design of Sand Mitigation Measures (SMM) has grown in the last decade and it is expected to further increase in the next years. However, the rigorous performance assessment of SMMs is still missing in the scientific literature and technical practice. On the one hand, the multiphysics and multiscale nature of the involved phenomena make analytical approaches inapplicable. On the other hand, current experimental physical and computational approaches do not fulfill alone modelling requirements and practical needs of infrastructure designers.The HyPer SMM project aims at finding a way forward by developing an innovative hybrid approach, as a brand-new design-and-assessment methodology in the field. It combines innovative Wind-Sand Computational Simulations (WSCS) and highly reliable Wind-Sand Tunnel Test (WSTT).The main scientific and training objectives of the project include:- the development of highly reliable WSTT to assess SMM performance;- the extension of WSTT-based SMM performance from scale to full-scale conditions by means of WSCS;- the drafting of best practices/guidelines to SMM performance assessment;- enrich Experience Researcher’s (ER) scientific competences on the specific topic;- enforce ER’s management skills and professional independence.In order to guarantee the multidisciplinary and intersectoral objectives, the layout of the project envisages the ER hosting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tools for Sustainabiltity Impact Assessment of the Forestry-Wood Chain' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The objective of EFORWOOD is to develop a quantitative decision support tool for Sustainability Impact Assessment of the European Forestry-Wood Chain (FWC) and subsets thereof (e.g. regional), covering forestry, industrial manufacturing, consumption and recycling. The objective will be achieved by:a) defining economic, environmental and social sustainability indicators,b) developing a tool for Sustainability Impact Assessment by integrating a set of models,c) supplying the tool with real data, aggregated as needed and appropriate,d) testing the tool in a stepwise procedure allowing adjustments to be made according to the experiences gained,e) applying the tool to assess the sustainability of the present European FWC (and subsets thereof) as well the impacts of potential major changes based on scenarios,f) making the adapted versions of the tool available to stakeholder groupings (industrial, political and others).The multi-functionality of the FWC is taken into account by using indicators to assess the sustainability of production processes and by including in the analysis the various products and services of the FWC. Wide stakeholder consultations will be used throughout the process to reach the objective. EFORWOOD will contribute to EU policies connected to the FWC, especially to the Sustainable Development Strategy. It will provide policy-makers, forest owners, the related industries and other stakeholders with a tool to strengthen the forest-based sector???s contribution towards a more sustainable Europe, thereby also improving its competitiveness. To achieve this, EFORWOOD gathers a consortium of highest-class experts, including the most representative forest-based sector confederations.EFORWOOD addresses with a high degree of relevance the objectives set out in th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Early-Stage Training in Advanced Life Science Research Across Europe (E-STAR)'.

assistant: **Objectives**

At its five sites in Britain, France, Germany and Italy, the European Molecular Biology Laboratory - EMBL, an International European Interest Organisation will offer structured and integrated training to early stage researchers leading to a doctoral degree within its International PhD Programme. 15 E-STAR fellows will be internationally recruited with consideration of gender equality. During 3 years, they will receive training that emphasizes interdisciplinary (biology, physics, chemistry, medicine, informatics) in the molecular life sciences in the socio-economic context. This programme will foster multi-site training and development of complementary skills. Internationally recognised, the EMBL has long-standing experience in training young researchers. Together with established European Partner Universities, it issues a Joint PhD Degree". Supportive human and material resources will enable formation and mobility of independent young researchers for the future. Sophisticated cutting-edge instrumentation and highly qualified scientists attract 350-500 applications per year. Support provided by the Marie Curie Action for the Training of Early Stage Researchers within the HRM (Human Resources and Mobility) Programme of the FP6 will provide 15 training opportunities and enhance the training and hosting of young researchers. Throughout the proposed research training, emphasis will be placed on ethical, safety, IPR, gender, presentation, writing and research management issues. Preparation, organisation and attendance of scientific workshops, symposia and conferences will be well acquainted with one another and all of the EMBL Faculty, establishing an early and highly functional personal and academic network. This will contribute highly to the enhancement and attractiveness o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CLINICOVERY, a versatile, high quality, environmental-friendly, easy to use e-Clinical solution for clinical research' to be submitted under Horizon 2020.

assistant: **Abstract**

The biomedical research is the key to reduce disease burden, and yields economic returns both through improved health gains (a healthy workforce) and through commercial exploitation of research outputs. The increasing disease burden has propelled the pharmaceutical industry to bring up new chemical entities into the market at a higher rate, increasing the number of clinical trials and generating huge quantum of clinical data. As a result, clinical trials are becoming increasingly complex, due the use of multiple data capture modalities (paper and pencil or/and Electronic Data Capture systems (EDC)), which require long implementation time, maintenance, upgrades and high economic investment, the need to evaluate more study endpoints and regulatory compliance with Medical Agencies and the growing number of stakeholders participating in the study. With CLINICOVERY, we will contribute to promote biomedical research in all the target sectors (Public and private) providing a versatile, regulatory compliance (FDA and EMA) cloud based platform that will reduce the implementation time (99%less) and costs (monitoring, price, travels, administrative expenses) and provides the capability to manage a huge and complicate data in large and international clinical trials to reach a faster market approval. Moreover, will be the unique platform in the market that contains a system to detect physiological patient data which gives advance warning of an adverse effect.The exploitation of the CLINICOVERY project will reach the EU countries, as the second region performing more clinical trials and then the Asia Pacific region, with the highest market growth (CAGR around 16% between 2015-2020) and US. In this way, the CLINICOVERY project will not only have a remarkable economic impact on our com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Transparent and flexible conductive polymers to boost the photovoltaic industry in Europe' (OHMIO) targeting Horizon 2020.

assistant: **Abstract**

Thin-film photovoltaic cells (TFPV) are highly dependent on transparent conductive polymers. The product developed by Intenanomat is a transparent conductive polymer which can be easily coated on a thin layer over different surfaces. OHMIO is a transparent conductive layer used as an HTM (hole transport material) for TFPV. OHMIO is the only HTM that is flexible enough to fit TFPV cells, achieving higher efficiencies because of their higher layer transparency in the IR range, reducing production costs and avoiding the use of corona treatment or similar.OHMIO will solve main current problems related to HTM: water severely damage the organic material layers (OHMIO is formulated without water), strong acid compositions reduce the TFPV shelf life (OHMIO is formulated in a liquid with selected additives and solvents) and high manufacturing costs (OHMIO will reduce the production process costs of an electronic device by up to 80%. OHMIO will involve savings of up to 200% in raw materials and several reductions of the carbon footprint. Additionally, OHMIO is easy to scale-up due to its manufacturing process does not need additional investment if the application changes. Intenanomat is a company managed by a highly qualified team of professionals with over 15 years of experience in the synthesis of different types of nanomaterials. They have created a new business unit to develop and commercialize OHMIO (patent registered P201730735).Intenanomat expects to achieve a market of 123,490 solar panels across Europe (37 MW of installed capacity) by 2025. They estimate a total sales volume will reach €11 million with an expected profit of €4.3 million, generating 20 new direct jobs and a NPV of €4.69 million and an IRR of 64% up to 2025.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'polyMOFs as promising drug delivery systems for antimicrobial therapy'.

assistant: **Concept**

The combination of metal organic frameworks (MOFs) and polymers is highly desirable since both contribute with outstanding features (high and defined porosity and crystallinity as well as tunable mechanical and chemical properties, respectively). In particular, they represent an appealing strategy in the field of drug delivery systems (DDS): i) the polymer can increase the chemical and colloidal stability of the DDS; ii) the polymer can present itself biological activity (e.g. antimicrobial) and stimuli response (e.g. pH, temperature); iii) the metal centers of the MOFs can exhibit intrinsic bioactivity (e.g. Zn2+, Cu2+, Fe3+) and iv) the MOF porosity can adsorb and progressively release exceptional cargoes of complementary active ingredients. Mostly associated as composite or core-shell, the coordination of the polymer as a building block to the metallic part of the MOF (polyMOF) is almost unexplored. Until now, only 10 polyMOFs (over 90,000 MOFs) have been reported, and all of them being in the exploratory phase, with no demonstrated potential applications. In this sense, highly robust polyMOFs will be here prepared based on polymers-containing polycomplexant ligands (instead of molecular polydentate ligands) and bioactive cations, stablishing a platform for the development of a library of polyMOFs with innovative combined antimicrobial properties. As proof of concept, the in vitro safety and potential activity of these novel polyMOFs will be evaluated for the challenging antimicrobial therapy. Finally, the scale-up and potential technology transfer of the most promising prototypes will be assessed within an industrial placement at Immaterial Ltd.


**Keywords:** MOF, polymers, polyMOF, drug delivery systems, antimicrobial therapy