RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Restoring anisotropy in living tissues 'in situ''.

assistant: **Concept**

Regenerative Medicine aims to restore the composition and organisation of damaged tissues of the human body to regain tissue functionality. When regenerating tissues inside the body (in situ), however, restoration of tissue structural organisation is commonly overlooked. This is particularly problematic for the heart, where functional performance is inseparable from its structurally aligned (= anisotropic) organisation at length scales from the cell to the organ. Two decades of cell-, gene- and material-based therapies to regenerate the damaged heart have mainly targeted the restoration of tissue composition, so far with limited success. I hypothesise that synergistic restoration of tissue anisotropy will radically improve therapy outcomes as it provides the proper environment for cell function, will promote coordinated contraction and halt adverse effects like fibrosis and inflammation. With my team I will test this hypothesis and explore an entirely new concept for restoring cardiac tissue anisotropy remotely using ultrasound. We will create living model systems at the cell and tissue level that recapitulate the increasing heterogeneity of damaged cardiac tissue following cardiac infarction, offer control of cardiac dynamics, and allow manipulation of structural organisation to delineate the interplay between (an)isotropy and cell and tissue functions. By integrating mechanistic understanding from cell and tissue level with multi-scale computational modelling in comparison with an ex vivo living heart model, we will rationally design strategies to mechanically RE-ALIGN diseased, disorganised cardiac tissue at the organ level and evaluate to what extend this can be achieved using ultrasound. By focusing on regenerating structure-function properties in situ, this multid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Internal and inertial  wave focusing and instability in closed fluid domains' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Energy transfer from large to small scale is a critical issue in the dynamics of ocean and atmosphere, and also an important fundamental question. Owing to density-stratification and rotation, ocean and atmosphere support internal and inertial waves which are known to propagate in form of oblique beams. Dispersion properties of these waves lead to strong variation of beam width upon reflection at a sloping boundary. In confined fluid domains, successive reflections may lead to formation of a closed trajectory, an internal wave attractor. Thus, the energy input at a global scale can be strongly concentrated on a closed loop of finite width, implying nonlinear instabilities very likely to occur. They arise indeed in form of parametric subharmonic instability which generates secondary waves having smaller scale than the width of the wave beams of the attractor. This two-step mechanism has been revealed experimentally by the applicant of this project during a short visit to the host organization. It was observed also that at large amplitude of input perturbation a patchwork structure of internal wave field is formed which hardly bears a resemblance to a classic pattern of a wave attractor. Observations of patchwork structures in ocean were recently reported in the literature.The scientific goal is to investigate this mechanism with an emphasis on issues important for interpretation of oceanographic data: What is the influence of the scale effects? How does the threshold amplitude needed to destabilize an attractor depend on the Reynolds number? How does the Reynolds number affect the spatial scale of secondary waves? Does the type of instability change (locally?) with amplitude of oscillations? How is formed the patchwork structure of the wave field? What are the energy con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'HypErspectraL Imaging Cancer Detection' (HELiCoiD).

assistant: **Innovation**

Starting with some specific types of cancers, this project will try to generalize the methodology to discriminate between healthy and malignant tissues in real-time during surgical procedures. Using the hyperspectral signatures of the healthy tissues and the same tissues affected by cancer, a mathematical model of how cancer affects to the hyperspectral signature will be derived. The research will start with the challenging task of brain cancer detection. A precise resection of the gliomas will minimize the negative effect of removing brain cells while assuring an effective tumour resection. The second type of tumours to be analysed will be the lung and breast cancers as they represent the two most common cancers in the world. Based on the experience gained during the evolution of the project and guided by the oncologist expertise, many other types of cancer out from the more than 200 that affect human beings will be studied. As cancer supposes a change in the cellular physiology, it should be detected as a change in the hyper-spectral signature. This project will try to determine if there is a certain pattern that could be identified as a cancer hyperspectral signature. Although previous works demonstrates that hyperspectral imaging can be used for certain cancer detection in animals, no application to human beings in real-time surgery has been found. This project will develop an experimental intraoperative setup based on non-invasive hyperspectral cameras connected to a platform running a set of algorithms capable of discriminate between healthy or pathological tissues. This information will be provided, through different display devices to the surgeon, overlapping normal viewing images with simulated colours that will indicate the cancer probability of the tissue pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Influence of Information Search on Preference Formation and Choice'.

assistant: **Innovation**

Cost-benefit analyses are routinely used by policy makers when designing environmental policy to weigh the costs and benefits of different policy alternatives, and stated choice experiments are used to value the non-marketed costs and benefits included in such analyses. Standard practice in stated choice experiments is to create a hypothetical market environment in which people choose among competing policy alternatives under the assumptions that they have complete information about all available policy alternatives, and that they are perfectly rational and maximize utility based on a clearly defined set of preferences, which can be retrieved when needed in any choice situation. In reality, these assumptions are questionable. Drawing on accumulating evidence from economics, psychology and marketing, this project aims to understand how searching for information about policy alternatives affects stated preference formation, learning and choice, and the extent to which this can address hypothetical bias. The project develops a novel experimental procedure that addresses important issues in stated choice experiments and make significant and original methodological contributions that advance current practice beyond state-of-the-art in both experimental design and data analysis. Improving the reliability of stated choice experiments will lead to improved estimates of non-marketed costs and benefits included in cost-benefit analyses. Through a broad uptake and use of these methods by stated preference practitioners, and increased awareness among policy makers, the methodological developments in this project can lead to improved policy recommendations and implementation across the EU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Understanding and Preventing Plant Susceptibility to Aphids', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Aphids are devastating insect pests of crops globally, and pose a major threat to food security. Crucially, there is a lack of durable genetic crop resistance against aphids, and current control relies almost exclusively on insecticides, which are costly and damaging to the environment and to which aphids develop resistance. These insects deliver proteins inside host plants, called effectors, to suppress the plant immune system and enhance susceptibility. I recently discovered that these effectors exhibit their activity via interacting with host plant proteins pointing to important conceptual parallels between plant-insect and plant-microbe interactions. This raises important new questions that urgently need to be addressed to enable development of novel protection strategies against aphids that are durable and sustainable. These are:What is the mechanistic and structural basis of aphid effector-triggered susceptibility?How can we interfere with aphid effector-triggered susceptibility?APHIDTRAP will address these questions using an innovative strategy: 1) I will introduce a structural biology approach to the insect effector biology field to reveal protein 3D structures of aphid effectors and their host protein targets in bound and unbound state, and determine how mutations in these proteins affect interactions and protein functions. 2) I will use both natural variants and mutants of effectors and host protein targets, combined with in planta functional assays to explore plant-aphid molecular co-evolution. 3) I will identify host protein target interactomes and investigate how mutations affect network functionality. 4) I will use information generated in 1-3 to develop and apply a synthetic biology approach to prevent aphid effector-triggered susceptibility in potato cro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Topological Mechanical Metamaterials'.

assistant: **Concept**

Mechanical metamaterials are man-made structures with tailored vibrational properties geared towards applications such as earth-quake protection, energy harvesting, or medical imaging. Recently, we promoted a new design principle for such materials: topological band-theory known from quantum condensed matter physics. To date, the use of topology in mechanical materials has been largely restricted to one or two dimensions, a central shortcoming for applications. The objective of TopMechMat is to address this challenge (i) by establishing a theoretical framework for topological mechanical metamaterials in three dimensions, (ii) by developing a novel algorithm enabling the sample design, and (iii) by experimentally validating the proposed materials.The current approach to topological mechanical systems is based on lcoal symmetries unnatural to classical mechanics. Crystalline symmetries, on the other hand, are ubiquitous in metamaterials and are known to stabilize topological phases. Using group cohomology techniques we will establish a theoretical framework for topological phonons in three dimensions. Translating a theoretical model into an actual sample requires extensive finite element simulations. However, the complexity of topological phonon models precludes the application of known design algorithms.  We plan to use a neural network to address this challenge. This will allow us to exploit the power of genetic algorithms in executing the required large-scale parameter scans. The successful implementation of this design algorithm will present us with an exciting opportunity: Mechanical systems might enable the discovery of yet unobserved topological phases of matter.We plan to build a three-axis scanning vibrometer to investigate additively manufactured metamaterial sa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of antibacterial MetAllic Glass mICrofibers' under Horizon 2020.

assistant: **Concept**

The proposed training-through-research aims to develop novel antibacterial materials for medical devices based on Zr-Cu-Ag metallic glasses in the form of microfibers. The major cause of metal implants retrieval is infection due to bacterial biofilm formation on their surface. Many studies have been conducted on the development of antibacterial coating on metallic implants, but evidence has shown numerous drawbacks associated with coatings including their lack of durability. “MAGIC” project proposes the development of Zr-Cu-Ag metallic glasses with generic and intrinsic antibacterial properties which makes them capable of battling antibiotic resistance bacterial infection with no further required coating. Meaningful development of this novel class of intrinsic antibacterial metals requires a fundamental understanding of their antibacterial mechanism which to date is not well-understood. Therefore, “MAGIC” project fundamental ambition is to discover the underlying antibacterial mechanism of innovative Zr-Cu-Ag metallic glasses though a novel interdisciplinary approach, combing materials engineering knowledge of metallic glasses with advanced biological analysis of bacteria. On the engineering side, the main antibacterial contributors “chemical composition” and “surface energy” of Zr-Cu-Ag metallic glass will be modified and controlled; On the biological analysis side, bacterial genetic and metabolic response to these changes will be studied by coupling basic metabolic assays with next-generation sequencing and omics techniques.  Furthermore, to facilitate the integration of antibacterial metallic glasses in the medical industry, “MAGIC” has an applied ambition to fabricate the best found Zr-Cu-Ag metallic glass (in terms of chemical composition and surface energy) in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'LEJO: Learned Approaches for Spatial Join Processing.' (LEJO).

assistant: **Concept**

Arguably 80% of all data is spatial. This calls for highly efficient and effective spatial data operations. Among them, spatial joins are frequently needed as a key primitive in various applications such as traffic management, robotics control, location-based services and even human brain modelling. However, existing spatial join approaches follow the traditional filter-and-refinement paradigm that is data distribution-oblivious. As a result, existing approaches are increasingly inefficient as spatial datasets to be joined become larger and more complex. The project LEJO is intended to make use of machine learning techniques to better understand the distributions of spatial data, and accordingly design learned approaches for highly efficient spatial join processing. Specifically, the research actions of LEJO include (1) learned approaches for binary spatial joins of memory-resident data; (2) learned approaches for binary spatial joins of disk-resident data; (3) learned approaches for multi-way spatial joins. The research actions will mainly concern analysis of the bottlenecks of existing approaches, design of distribution-aware space/data partitioning, design of learned model based indexes and join algorithms, and implementation and evaluation of the proposed techniques. These research actions, as well as project planning and management, will significantly strengthen the fellows research profile and manage skill. This in turn will put him in a considerably better position for future career development after the project. Moreover, a two-way knowledge transfer is expected as LEJO combines the fellows expertise in machine learning and the host universitys expertise in spatial data management. Focusing on the challenging intersection of spatial data management and machine l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Integrated optical coupling for low loss electro-optic interconnects' (CoupledEOT) under Horizon Europe.

assistant: **Objectives**

The development of electrooptic transducers, that can effectively interface between microwave and optical frequencies, is critical to upcoming quantum technologies, such as distributed quantum computing over multiple superconducting qubit processors and the inclusion of any microwave-based quantum technologies in a future quantum internet. These transducers would furthermore also benefit classical applications where sensitive all-optical detection of microwave and THz frequency signals is beneficial, such as in radars and remote sensing. However, the development of such devices has been challenging owing to the more than 5 orders of magnitude energy gap between the microwave and optical frequencies. Only a handful of quantum-signal-enabled transducers exist in a few research labs around the world with no commercial availability. In this project, we develop a critical new functionality for one of the most successful platforms, i.e. ultra-low loss electrooptic transducers based on high purity bulk optical crystals. In CoupledEOT, we will develop a new optical coupling method for high index whispering gallery mode resonators that is high efficiency, easy to operate and robust against thermal contractions. This will make the highest performance quantum transducers compatible with common packaging solutions and commercial applications both in the quantum and classical domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Conflictual Democracy: Urban politics, gender and local governance in post-revolution Tunisia'.

assistant: **Innovation**

The 2011 Arab uprisings were extraordinary events. The Middle East and North Africa (MENA) region has long been understood as the bastion of authoritarianism, stifled markets and Islamic fundamentalism. The protestors who filled streets and city squares in 2011 disrupted these narratives. A decade after the uprisings, I propose to investigate whether politics leads to the weakening of democracy. In a context of deepening socio-economic inequalities, I explore this question from Tunisia, the country celebrated in foreign policy circles as ‘the only hope’ of the Arab revolutions. The hypothesis I aim to test is whether a conflictual democracy is being consolidated at the local level, where ‘the state’, the space of institutionalized politics, meets the street, the space of contestation. Through this fellowship, my research attends to whether and how conflictual democracy in post-revolution Tunisia which manifests at the intersection of municipalities as spaces of encounter, the gendering of these local governments, and the legal battles these decentralized entities have waged against the deconcentrated state. My research engages with three bodies of literature: the urban studies literature on the political, feminist theories of the space, and the political geography literature on scale and topologies of power. The conceptual innovation of this project lies in bridging political theory, urban studies, and feminist studies to theorize the dynamics of an unfolding conflictual democracy while being attentive to questions of gender, the perceived threat of political Islam and the legal aspects of politics. In addition to its theoretical rigor, I aim to build on my professional experience in policy circles and my knowledge of Tunisian politics to develop policy briefs about dec