RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Symmetries and the constitution of objectivity in quantum physics: A study on the non-representationalist theories of knowledge' under Seventh Framework.

assistant: **Concept**

Recent years have seen a surge of research in the philosophy of physics. In particular, the conceptual and epistemological problems related to the interpretation of quantum mechanics have been reformulated within the framework of the current debate on structural realism. The proposed project presents an original approach, bordering between epistemology and theoretical physics, to address those philosophical issues. Such an approach adopts both an instrumentalist conception of theories and a constructivist conception of knowledge, in which experimental facts and theoretical models are co-constituted through scientific practice. The overall goal is to point out the shortcomings of the representationalist paradigm of knowledge, and to establish the objectivity of science without relying on the alleged correspondence between the theoretical symbolism and a pre-constituted reality. This program involves two steps: (1) an analysis of the notion of objectivity inspired by both transcendental (i.e. neo-Kantian) philosophy and the pragmatist trends in the philosophy of language, and (2) the formal derivation of the mathematical (predictive) structure of quantum models from the conditions of possibility of an objective know-how (to be achieved by exploiting the link between invariance conditions, symmetry groups and conservation principles). The proposed constructivist account of objectivity provides a very original contribution to a topical debate in the philosophy of physics, and outlines an innovative framework to deal with the interpretational issues of quantum mechanics. It also has wide-ranging implications for epistemology and strong connections with the constructivist trends in cognitive sciences. The project comprises an initial training phase at Princeton University und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CarbON Valorisation in Energy-efficient Green fuels' (CONVERGE), addressing dissemination and exploitation.

assistant: **Impact**

The CONVERGE project will validate an innovative value chain for the production of green biodiesel. The innovative configuration will reduce the total number of unit operations needed to achieve the conversion of secondary biomass and waste streams into green biodiesel, while simultaneously producing additional intermediate green refinery products.  The CONVERGE project will demonstrate 5 unit operations in 3 grouped processing steps (pre-processing, valorization & enhanced methanol), taking these new combinations from the discovery stage (TRL3) to development stage (TRL5).  The combination of these technologies will increase the biodiesel production from secondary biomass by 12% together with biodiesel production will be reduced by up to 2100 M€ across Europe.  In this project, risks are mitigated from the very start; each unit can be implemented as a stand-alone function within a modified state-of-the-art technology chain and thus provide immediate performance and energy efficiency improvements. Moreover, the units when used together have synergies that allow even more efficiency gains.  The new units to be taken from discovery to development are: CCT: Catalytic cracking of tars from a gasifier to below green C8, integrated with  BITS: Recovery of refinery products including aromatics for green C6-C8 fraction (BTX). Then, SER: Sorption-Enhanced Reforming is adopted for H2 and CO2 separation, integrated with  EHC: Highly efficient electrochemical compression of green H2 with by-product fuel EMM: Enhanced Methanol Membrane synthesis to ensure green biodiesel production. The technology will be validated  for more than 2000 cumulated hours. The CONVERGE consortium covers the whole value chain from secondary biomass supply to biodiesel production, demonstrating the new uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plant mitochondrial genome engineering: technology development and application to study fundamental aspects of mitochondrial gene expression' (PlaMitEng) under Horizon Europe.

assistant: **Objectives**

PlaMitEng has the highly ambitious overall objective to make the mitochondrial genome of seed plants amenable to genetic engineering. The project consists of two complementary work packages (WPs). In WP1, TALEN-GDM, a technology for plant mitochondrial genome editing recently developed by us will be used to systematically study plant mitochondrial gene expression in vivo. The focus will be on translation initiation and translational regulation in mitochondria, the mechanisms of which are currently completely unknown. In WP2, PlaMitEng will develop a technology for direct genetic transformation of the plant mitochondrial genome. The mitochondrial genome is the only genome of the plant cell that, due to the lack of a mitochondrion-specific selection system, is not amenable to transformation and has remained recalcitrant to the insertion and expression of transgenes. Taking advantage of (i) our recent construction of a mitochondrion-specific selectable marker gene, (ii) the generation of a dedicated recipient line for mitochondrial transformation, and (iii) the design of a new transformation strategy (referred to as multivectorial transformation) that will enable the large-scale testing of expression elements for their suitability to drive the expression of mitochondrial transgenes in vivo, PlaMitEng will pursue the development of a robust technology for transformation of the plant mitochondrial genome. The possibility to express transgenes from plant mitochondrial genomes will open up entirely new opportunities in both basic and applied research, and pave the way to harnessing the enormous potential of mitochondrial biotechnology and synthetic biology.


**Keywords:** mitochondrion,  translation,  translational regulation,  plant transformation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The pseudodynamic test method applied to seismic isolation of structure' (1994-1998).

assistant: **Concept**

The objective of this research is to use the Pseudo Dynamic Test (PDT) method to study the dynamic behaviour of base isolated structures. The PDT method will be implemented at the Joint Research Center (JRC) using the facilities of the European Laboratory for Structural Assessment (ELSA). Throughout this research the applicability and reliability of the method to base isolated structures will be studied. The research work will be carried out with the support of two Italian industries specialised in the production of base isolation devices. The results of the testing will constitute a valuable tool to correlate with analytical results and extrapolate guidelines for the design of safer and more efficient base isolated bridge and building structures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'European Spectroscopy Laboratory to model the materials of the future'.

assistant: **Concept**

The roadmap of the European Materials Modelling Council has identified a strong need in European industries for materials modelling, especially on the atomic, molecular and quantum level. A key bottleneck is the lack of scientists that can translate industrial problems into modelling strategies, to carry out simulations with the right tools, or to derive results of practical engineering value. EUSpecLab addresses this problem by training a new generation of innovative material scientists that will bridge the gap between industrial processes and theoretical understanding, and leverage novel informatics tools in artificial intelligence. EUSpecLab will train students in the theory, development and application of computer codes for the modelling of cutting-edge spectroscopies. Examples are the time and spin-resolved spectroscopies at the forefront of fundamental research in the characterization and designing of the new materials that will shape the future of our society. The results will be exploited using machine learning, to leverage first principles results and explore vast classes of materials. To provide beyond state-of-the-art training, EUSpecLab gathers the expertise of scientists in quantum physics/chemistry, in theory/ modelling and experimental methods, in computer science and artificial intelligence, in atomic and spin/time structure, working in academic laboratories and in companies involved in the making and modelling of materials. The students will become fluent with high-level programming, able to develop innovative computational approaches and software. With the involvement of the software or applied research companies, the Researchers will be exposed to the process of transforming research programs into professionally supported simulation platforms with app
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'IFR RPAS Control in Airports and TMA'.

assistant: **Concept**

This proposal addresses the topic “Control of RPAS in the TMA” of the H2020 call “SESAR-ER4-28-2019”. Its objective is to provide means for a safe and efficient integration of RPAS (Remotely Piloted Aircraft Systems) into the existing Air Traffic Control (ATC) procedures and infrastructures within Terminal Manoeuvring Areas (TMA) under Instrument Flight Rules (IFR). The main goals of the INVIRCAT project are the creation of a concept of operations for remotely piloted aircraft systems in the terminal manoeuvring area of airports, assessing it through simulations and draft a set of recommendations for rulemakers and standardization bodies.In INVIRCAT a CONOPS will be elaborated for full accommodation of RPAS in TMA environments, including Automatic Take-Off and Landing (ATOL) procedures. These CONOPS will serve as a basis for implementing a cooperative, heterogeneous and distributed simulation infrastructure to enable a full IFR RPAS flight from one airport to another including all phases of flight. Based on the results of the simulations and the validation of the CONOPS a set of high level operational and technical requirements will be defined.To meet the objectives, the INVIRCAT consortium is formed of a balanced group representing the most innovative research arms of the ATM, ATC, UAS, UTM and UAM industries. In addition, a close collaboration with related projects on the topics “SESAR-ER4-29-2019: Remain Well Clear for IFR RPAS Integration in Class D-G Airspace” and “SESAR-ER4-30-2019: RPAS for Manned Flight Contingency Management” will be established, to feed their results into the concept of INVIRCAT. An Advisory Board will be set-up to validate the requirements and to explore the challenges presented by the co-existence of conventional manned aviation, drones and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Market Impact through Disruptive Innovation in Clean Energy Technologies'.

assistant: **Concept**

MI_DICE is a Pilot Action to support market uptake of disruptive energy technologies. Pre-selected H2020 projects will be supported at early-stage research (TRL3/4) with a systemic approach to commercialization. The approach complements developments in the technology dimension (the TRL) with Intellectual Property (IP), market, access to finance, as well as regulation/legislation.A stage-gate methodology will be followed. The first stage will establish the path to commercialization (Feasibility Study), after which a decision will be taken by DG RTD about the progress or termination of the selected Project. If green light is given, selected Projects will develop along the technology as well as the other dimensions. Progress and probability for impact in themarket will be (re-)assessed every six months and another gate decision will be taken by DG RTD. MI_DICE will support the Feasibility Study as well as subsequent stages with proven tools and experienced experts.At each step of the stage gating process, insights and lessons learnt with respect to market uptake will be shared with DG RTD.


**Keywords:** disruptive innovation, market uptake, market impact, clean energy technology, de-risking business, case
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'South-East European TSO Challenges', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The proposed project addresses the needs of South-East European TSOs in their effort towards harmonization and integration of the region with the rest of the European power network. Diagnostics, modeling and monitoring generate huge amounts of data that create the need for efficient storage and analysis of the collected information for better decision making and execution; under this respect the use of a common computational platform is highly recommendable and will be a focus of the proposed project. The project objectives are: • Assist in harmonizing regulatory and commercial frameworks in South East Europe to facilitate cross-border trading of both power and grid services, ensuring that they will accommodate a wide range of operating situations; • Development of systems and tools that will enable TSOs and other players in the energy field to utilize innovative service arrangements to improve their efficiency and enhance their services to customers; • Develop and implement methods and techniques for capacity calculation and allocation. • Establish corrective procedures to ensure security of power transmission and grid connections. • Ensuring the successful interfacing of new and old methods and tools for the representation and modeling of power networks. The consortium has a strong representation (50%) of TSOs that take part from the initial to the final stages of the project to ensure appropriate input of information, proper use of methods and techniques and practicality of outcomes. Academic institutions with expertise and research in the field are heavily involved through their electrical engineering departments. Furthermore international cooperation is ensured with the participation of two TSOs and two academic institutions from EU neighboring countries. The resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'New PTFE Production Process for High Value Applications' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Established in 1996 in north Italy, our company Macchine Speciali, started out as a company designing and manufacturing machinery. Over the years, we have increased our competence and knowledge, focusing on machinery construction and the production process for the cable industry. Our wealth of expertise allows us to showcase and offer an extended machinery range to our customers including: winding/unwinding systems and stranding machines and specialised extrusion lines for PVC (Polyvinyl chloride) and PTFE (Polytetrafluoroethylene). In particular, the latter has made us one of the leaders in semi-finished PTFE plant.Since our company was founded, we have ensured that innovation plays a key role in everything we do – from proactively researching new materials and technologies to executing a business strategy – thus, consolidating our position in the electrical and electronic cables markets nationally (Production bids and contracts > 350/year; Turnover €2.2M in 2014). Listening to our customers’ feedback from the cable sector, and their needs for processes with enhanced performances and energy savings, we have been working on a new process called ProPApp for the production of PTFE films and tapes: while today’s technologies are limited by the high viscosity and melting temperature of PTFE, resulting in lowering its final properties, our innovative ProPApp process will enable the cost-effective production of expanded PTFE (e-PTFE) ,a lightweight version of PTFE (density reduced by 50%) with optimal performances for electrical and power cables applications. This new process will allow us to consolidate our presence in the cable market and penetrate additional, more lucrative ones (i.e. aerospace, medical, petro-chemical markets) thus significantly increasing our turnover.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Chemotactic Super-Selective Targeting of Gliomas'.

assistant: **Concept**

I propose here a research program aimed to the design a completely new platform for drug delivery. I will combine our existing repertoire of molecular engineering tools based around our established approach to design responsive nanoparticles known as Polymersomes to integrate new features using clinically safe and biodegradable components that will make them super-selective and chemotactic toward glucose gradients so to deliver large therapeutic payload into the central nervous systems and the brain in particular targeting cancer cells harbouring within the healthy. We will do so by engineering components using supramolecular interaction inspired by biological complexity equipping carriers with the ability to self-propelled as a function of glucose gradient. I will complement our proposed design with advanced biological characterisation associating functional information arising form the physiological barrier to structural parameters integrated into the final carrier design.


**Keywords:** Drug delivery, Blood Brain Barriers, Active colloids, multivalent targeting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Liver Spatial Omics' (LSO).

assistant: **Concept**

The mammalian liver is a heterogeneous, yet highly structured organ, which performs diverse functions to maintain organismal homeostasis. Hepatocytes operate in repeating hexagonally shaped units termed lobules that are polarized by centripetal blood flow and morphogens. This polarized microenvironment facilitates optimal function by localizing specific processes to distinct lobule layers, a phenomenon known as ‘liver zonation’. While zonation of some key liver functions has been known for years, using spatially resolved single cell transcriptomics, we recently discovered that about 50% of liver genes are zonated. This surprisingly broad spatial heterogeneity raises a fundamental question - do hepatocytes form a uniform population that differs due to spatially graded inputs or are hepatocytes at different zones in fact distinct cell types? In this proposal we will tackle this question by developing techniques for sorting massive amounts of hepatocytes from defined tissue coordinates at high spatial resolution using zonated surface markers, new zonated reporter mouse models and mRNA content. We will perform a deep and comprehensive profiling of the hepatocyte genome, methylome, epigenome, transcriptome, proteome and metabolome at each zone to characterize liver zonation at all relevant cellular scales. We will also develop an ex-vivo system to functionally characterize the response of hepatocytes from distinct zones to identical input stimuli and the ability of hepatocytes to inter-convert to hepatocytes with differing zonal identities. These experiments will be performed in different metabolic states and along a high fat diet. This project will uncover new features of liver zonation in health and disease and redefine the hepatocyte cell state. Our approach for spatially