RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Augmented Usage of Track by Optimisation of Maintenance, Allocation and Inspection of railway Networks'.

assistant: **Innovation**

Rail traffic has increased much in the last decade. This development and the need for model shift from road to rail to decrease CO2 emission, creates a challenge for the railway industry to improve capacity in the network while the need of capacity for maintenance also increases.The challenge of the project is to do more effective inspection and maintenance in less time.Therefore the project focus is to optimise and automate maintenance & inspection where possible, also to introduce new planning & scheduling tools and methodology. The project aims to reduce the possession time around 40%.To achieve this five objectives are set:1: adopting best practice from other industries in maintenance optimisation (e.g. highways, aerospace).2: developing novel track inspection approaches for freight routes with a scope on in-train measuring and self inspecting switch. 3: researching and assessing innovations that can improve the effectiveness and efficiency of large scale inspection & maintenance processes with a scope on track and switch maintenance, track inspection; 4: further developing of key technologies that will drive the development of modular infrastructure design. 5: developing a new maintenance planning and scheduling tool that is able to optimise the maintenance activities, taking account of the benefits brought about by other improvements in this project.To achieve these objectives, the project will be organised into 8 Work Packages (WP): WP1: benchmark & evaluation criteria; WP2: improvement specifications for WP3 : improve inspection; WP4:improve maintenance; WP5:improve planning & scheduling and WP6: demonstration. WP7 manages dissemination, exploitation and training. WP8 manages the project.The Consortiums’ composition covers the whole railway maintenance and inspe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Infrared nanospectroscopy to understand and combat Alzheimer's disease' (2021-2027).

assistant: **Concept**

Neurodegenerative diseases are a ticking time-bomb for health care systems because they are care-intensive and will soon become much more wide-spread due to increased life expectancy. Their most common form is Alzheimer's disease (AD), in which the amyloid-ß (Aß) peptide aggregates to amyloid fibers that accumulate in plaques in the human brain. We will study unresolved key aspects of AD in order to understand and eventually combat the disease. The objectives are:1. To map the biochemical composition of plaques with unprecedented spatial resolution in order to understand the role of lipids in plaque organization and development - possibly leading to a biochemistry-based classification of these brain lesions,2. To characterize co–aggregates of Aß with other amyloidogenic polypeptides, which may link different diseases and improve diagnosis,3. To improve anti-amyloid peptides for a possible new AD treatment by characterizing and optimizing their interaction with Aß, and4. To establish isotope-edited nanoscale infrared (IR) imaging as a versatile tool to characterize chemically similar components of mixtures.We will exploit the advantages of novel approaches in IR spectroscopy to move the field forward in areas that are difficult for more common methods. IR nanospectroscopy with 20 nm spatial resolution will be used throughout and will be combined for the Aß studies with isotope-edition and with Fourier transform IR spectroscopy. The supervisor is a well-know expert in biological IR spectroscopy and has recently established all approaches in his work. I, as the researcher, will be trained in advanced IR spectroscopy as well as in transferable skills, incl. leadership, and in pedagogics. The expertise in IR nanospectroscopy will particularly promote my career because the te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Inflammasome: a novel therapeutic target for the treatment of Hypoxic Brain Injury in Neonates' in the context of a Horizon 2020 call.

assistant: **Objectives**

Following 4.5 years abroad I hope to work as a MSCA Fellow to tackle the issue of deleterious neuroinflammation following hypoxic injury in newborns. Hypoxic Ischemic Encephalopathy (HIE) describes brain injury that occurs when an infant’s brain does not receive enough oxygen & blood. Approximately 15-25% of patients die, 1 in 4 develop severe and permanent neurological disorders including, Cerebral Palsy & later-life Epilepsy. There are currently no successful treatment options & HIE has withstood attempts to improve outcome. A critical immune complex, the inflammasome was discovered in 2002 that senses ‘danger’ & processes potent inflammatory cytokines to bioactive forms. I have generated novel data demonstrating a role for the inflammasome & specifically targeting it for treatment of hypoxic brain injury. This study advances this by assessing the exact contribution of its activity on a cellular level & temporally targeting the complex as a novel treatment. I will employ established preclinical models of hypoxic brain injury, advanced imaging techniques (2- photon) & novel small molecule inhibitors of the complex. I will work at the Royal College of Surgeons in Ireland (RCSI) with supervisor Prof David Henshall, Director of the FutureNeuro Centre, a multi-institutional national centre for chronic & rare neurological disease research. Ultimately, our proposal will aid design & improvement of current clinical care strategies for infant patients with HIE. I will work with top neuroscientists within FutureNeuro & Europe (Prof Mallard, Sweden), the leading inflammasome company, Inflazome & its CSO Prof O’ Neill and Neonatologists including Prof Murray (Cork, Ireland). My collaboration with these leaders across multiple sectors will expand my competencies/transferable skill
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Methodology Development and Validation of WEight Optimized Stiffeners Run-Out Design for Future Composite Wings' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

DOVER aims to develop a design optimization tool and methodology dedicated to support the design of innovative and weight-optimized composite panel configurations with capability to improve all areas and configuration parameters such as geometries, stacking sequences or anti-peeling fasteners. The resulting methodology accuracy and reliability is to be validated by means of experimental tests. The project will be carried out in a 41-month time span. DOVER solution proposal is to create and validate a design tool and methodology that enables optimization of wing structural composite panels. The developed tool will provide an environment for the investigation of innovative lightweight shapes including stiffener geometry, thicknesses and lay-ups of different components, shape of the tapering or anti-peeling fasteners configuration. By means of this tool, the designer will be able to predict the failure of any stiffener run-out configuration and obtain a global panel optimization with considerable time savings, because it will not require any complex numerical models to predict behaviour, and economical, because it will not be necessary to carry out expensive testing campaigns.To achieve this solution, DOVER is structured in different stages that ensure maximum quality, accuracy and reliability. An initial experimental study of stiffener run-out behaviour will establish an experimental base that will be used to develop a model and to generate failure criteria prediction methodology. This methodology will be put in practice by designing different configurations of innovative stiffener run-outs. Optimized solutions will be evaluated and correlated against experimental results. For that, at a final stage, mono and multi stiffener panels will be manufactured, and stress and str
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Building Capacity for Design enabled Innovation in Urban Environments' (DESIGNSCAPES) under Horizon 2020.

assistant: **Objectives**

Innovation is relevant not only to economic sustainability but also to social and cultural life. Therefore, the creation of an organizational climate enabling and catalyzing innovation deserves special attention and needs to be explored from a sound operational perspective. Cities embed this organizational climate (Jacobs, 1969) and are by nature innovation generative systems.It is within this perspective that the DESIGNSCAPES project aims to realize a better uptake, and further enhancement and upscaling, of Design enabled Innovation in Europe, through direct financial support to flagship and innovation generating initiatives as well as a huge capacity building effort targeting multiple stakeholder groups (citizens, researchers, practitioners, innovators and policy makers). In so doing, we will foster the linkages between research, policy and practice and contribute to making Europe a global leader in the domain.The main features of the DESIGNSCAPES project are the following:- It builds upon the generative potential of innovation in cities - It leverages Design Thinking and Design Driven Innovation concepts as blueprints.- It has a direct and purposeful focus on the scalability potential of Design enabled Innovation- It proposes an original, holistic, evaluation, replication and impacts assessment framework.- It makes use of a “supportive governance approach”.Expected results include: a City Snap Shot tested in 10 countries and 12 cities, a EU Catalogue of Design enabled innovations, Training Modules for local facilitators and innovators, Policy Briefs, e-Publications and a final Conference. Approximately €1.5 million will distributed among 50+ new Design enabled initiatives as required by the H2020 call through 3 consecutive yearly rounds of a 3-staged Technical and Fi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Whole-body Adaptive Locomotion and Manipulation' (WALK-MAN), addressing dissemination and exploitation.

assistant: **Impact**

Despite the remarkable developments in robotics, and the many years and the millions Euros spent, robotics could not yet demonstrate readiness to help in recent catastrophic situations. This project aims to develop a humanoid that will be able to operate in de-structured spaces, demonstrating apt and strong manipulation, robust locomotion, and physical sturdiness. We aim to advance the locomotion capabilities to permit humanoids to walk and balance against disturbances by exploiting their whole body motion and the workspace constraints.  We target to advance the manipulation skills of humanoids by looking on new hand that combine robustness and adaptability allowing less delicate use of the hands for manipulation as well for locomotion/balancing assistance. We rely on four powerful enabling ideas: 1) an integrated approach to whole-body locomotion and manipulation (loco-manipulation), where all body parts contribute to produce and balance motion, as well as to produce the large manipulation forces needed in a disaster environment; 2) loco-manipulation affordances mediating perception, cognition and action; 3) soft robotic actuators technologies, to afford adaptability and robustness, and 4) ) efficient any-time planning algorithms exploiting a robust and consistent control hierarchy based on the theory of motion description languages and symbolic control. We will define stringent and plausible validation scenarios, including but not limited to those of the DARPA robotic challenge.  The Consortium will generate a European entry to the DARPA Robotic Challenge to participate in the final trials in December 2014, to which we have been officially invited.  However, our work will not be targeted to a system adjusted to the requirements of this or any specific challenge. In th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Development of novel peptide based radiopharmaceuticals for in vivo receptor associated tumor diagnosis and therapy'.

assistant: **Innovation**

ObjectivesThe major goal of this project is to develop novel neurotensin (NT) and bombesin/gastrin releasing peptide (BBN/GRP) analogs, that can be tagged with radionuclides appropriate for either diagnostic (PET, SPECT) or therapeutic application. The new peptide based radioagents will be evaluated as new molecular probes for the early in vivo diagnosis and/or therapy of NT or BBN/GRP receptor positive tumors and their metastases.Neuropeptides are a class of very potent native substances controlling important biological processes through high affinity receptors located on the cell membrane of target cells. After the discovery had been made that a wide spectrum of malignant cells also express high affinity and high density peptide receptors on their surface, neuropeptides have been drawing increasing attention in the Nuclear Medicine world. Their superiority over Monoclonal Antibodies (MoAbs) used so far relies upon their unique biological characteristics, most importantly their rapid and specific localization on target cells in combination with their fast blood clearance. It is therefore their pharmacokinetics as well as target specificity that make them attractive vectors for targeting cancer, a strategy already explored successfully forsomatostatin (SS). Indeed, the in vivo imaging of SS receptors involved in much pathology by radiolabeled SS analogs is a new powerful and fast expanding technique. However, since many frequently occurring and devastating tumors do not express SS receptors, it is imperative to search for alternative neuropeptide receptors expressed by these tumors. Recent evidence reports that such malignant lesions, like small cell lung cancer (SCLC), colon carcinoma and certain meningiomas, express high affinity and density bombes in (BBN) and neurot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identifying the Heat Shock Factor -1 Longevity Assurance and Proteostasis Co-regulators and Target genes' under Seventh Framework.

assistant: **Concept**

The Heat shock Factor 1 (HSF-1) is a transcription factor that upon activation enters the nucleus and regulates the transcription of its target gene networks. In the nematode C. elegans, HSF-1 is critical for the regulation of a variety of fundamental biological functions including development and stress resistance. In addition, it mediates protection from toxic protein aggregation and longevity facilitated by reduction of the Insulin/IGF signaling pathway, functions that point to HSF-1 as a promising target for the development of neurodegeneration therapies. Despite its key regulatory importance and therapeutic potential, little is known about the gene netwroks regulated by HSF-1 and its co-factors. Here I propose a systematic study designed to explore the different aspects of HSF-1 roles in regulating longevity and countering toxic protein aggregation. First the timing in which HSF-1 regulates longevity and counter toxicity associated with the aggregation of the Alzheimer’s disease linked peptide, Aβ. Next, the relations with components of the Insulin/IGF signaling pathway and its target genes networks will be studied at the correct temporal pattern, followed by exploration of the molecular co-factors that interact with HSF-1 at the longevity assurance time window. The proposed study will shed light on the molecular mechanisms that prevent late onset neurodegenerative disorders to emerge early in life and will point to new avenues towards the development of novel neurodegeneration therapies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Guadua bamboo - research for sustainable management and markets of bamboo in colombia and costa rica' in the context of a Fifth Framework call.

assistant: **Objectives**

In many countries of the world bamboos play an important role as a renewable resource. Colombia has a long tradition of using the culms of Guadua angustifolia for constructive purposes. In recent years Costa Rica has conducted much research regarding several species of bamboo. The project will systemize the dispersed information sources on production, processing and marketing of bamboos and gather new data and experience from both countries. Research will be conducted in order to select varieties with superior properties and to improve the quality of the raw material. Emphasis is put on the socio-economic framework of bamboo production regarding its economic importance at the farm level and in marketing. The database will be made accessible to producers in order to promote sustainable production of bamboo and help create additional income for farmers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of a multiplex nanofluidic assay for selective detection and monitoring of Alzheimer's disease biomarkers' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In this work, I propose the use of a nano/microfluidic system to detect biomarkers relevant to Alzheimer’s disease (AD). The use of this system could give earlier and more accurate diagnoses, as well as provide the opportunity for therapeutic interventions and effective disease monitoring. Prior to the diagnosis of dementia and even before the appearance of plaques and tangles, it is suspected that biochemical changes have begun to occur in the brain that eventually lead to AD. Due to the brain being a particularly difficult organ to access, the search for biomarkers has focused primarily on cerebrospinal fluid (CSF) and blood. Because the available sample and biomarker levels are low, clinical tools that can measure candidate biomarkers for reproducible detection are currently insufficient. Here we propose a nanofluidic system with well-defined surface chemistry to greatly improve the sensitivity, selectivity and reproducibility in detection of biomarkers found in CSF. Our device will be fabricated using standard silicon microfabrication procedures to produce highly controlled channels for sample handling and multiplex detection. By working under continuous-flow conditions rather than in batch format, we eliminate variability due to mass transport limitations while allowing for improved standardization. Concentrating the antibodies to a discrete area will increase selectivity and allow amyloid-beta quantitation in spiked serum and real CSF of normal and Alzheimer’s donor samples to be achieved. I believe that development of a multiplex diagnostic tool will offer many more people access to better disease diagnosis management and assist in the search for better therapeutics that not only slow disease progression but potentially reverse it.