RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Unravelling Fragile 1D Quantum States of Matter Through Ultra-sensitive Imaging' (See-1D-Qmatter).

assistant: **Concept**

In condensed matter physics there are several iconic predictions that have evaded experimental discovery for many decades. Well-known examples include the proposed fractionally-charged quasiparticles in one-dimension, the theorized quantum crystal of electrons, and the elusive Kondo cloud. These sought-after many-body states all share two key aspects underscoring why they are so hard to discover: They each involve a fragile quantum state of matter that is destroyed easily by disorder or elevated temperatures, and in each case the distinguishing fingerprint is encoded in their real-space structure, which is often difficult to probe directly. The discovery of such phases therefore requires two challenging experimental components: A superb material system in which these phases can be generated, and a novel real-space probe that can image their spatial structure, yet is minimally invasive as not to destroy them.Recently, we have developed a radically new approach for creating the state-of-the-art in both material systems and scanning probes, based on carbon nanotube devices of unprecedented complexity and cleanliness. With these components in place, we are poised to make the next quantum leap in technology by building a conceptually new experimental platform in which fragile quantum states of matter can be realized and studied microscopically: We will use a nanotube single-electron-transistor as a high-resolution, ultrasensitive scanning charge detector to non-invasively image an exotic quantum state within a second pristine nanotube.  With this new platform we will thus be able to address several foundational questions in condensed matter physics (including those mentioned above) and unravel their underlying physics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Solid-state flow as a novel approach for the fabrication of photonic devices'.

assistant: **Concept**

The development of advanced photon-based technologies offers exciting promises in fields of crucial importance for the development of sustainable societies such as energy and food management, security and health care. Innovative photonic devices will however reveal their true potential if we can deploy their functionalities not only on rigid wafers, but also over large-area, flexible and stretchable substrates. Indeed, providing energy harvesting, sensing, or stimulating abilities over windows, screens, food packages, wearable textiles, or even biological tissues will be invaluable technological breakthroughs. Today, however, conventional fabrication approaches remain difficult to scale to large area, and are not well adapted to the mechanical and topological requirements of non-rigid and curved substrates. In FLOWTONICS, we propose innovative materials processing approaches and device architectures to enable the simple and scalable fabrication of nano-structured photonic systems compatible with flexible and stretchable substrates. Our strategy is to direct the flow of optical materials through an innovative and thus far unexplored exploitation of the solid-state dewetting and thermal drawing processes. Our objectives are three-fold: (1) Study and demonstrate, for the first time, the strong potential of the dewetting of chalcogenide glasses layers for the fabrication of large area photonic devices; (2) Show that dewetting can also be exploited to realize photonic architectures onto engineered, nano-imprinted flexible and stretchable polymer substrates; (3) Demonstrate, for the first time, the use of the thermal drawing process as a novel tool to realize advanced flexible and stretchable photonic ribbons and fibers. These novel approaches can contribute to game-changing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Head to tail imaging of fluorescent carbon nanotubes for the characterization of the brain extracellular space'.

assistant: **Concept**

The NanoHeadTail proposes a novel and original approach combining fluorescence microscopy and nanotechnology to resolve the morphological and rheological properties of the brain extracellular space (ECS) at the nanoscale. Current methods allow to determine the local dimensions and fluidity of the ECS, but they do not allow to resolve its structural complexity and are limited to an analysis in 2D. This project proposes the simultaneous monitoring of the position, the translational and rotational diffusion of fluorescent probes over time and in 3D, allowing to determine the volumetric structure, fluidity and inner organization of the ECS locally. For that, a novel type of asymmetric probes will be designed based on the localized functionalization of single-walled carbon nanotubes with fluorescent color centers at their ends, analyzed using a custom cutting-edge fluorescence microscope and tested in live brain tissues from mice models of the Parkinson’s disease. The applicant will bring his strong expertise in the photophysics and chemistry of carbon nanotubes, critical for the preparation of the probes. In parallel, the fellow will gain a high-level hands-on training on optics assembly, super resolution microscopy and single particle tracking, imaging analysis and neurosciences. The project will be performed at the IOGS-LP2N (CNRS/Univ. Bordeaux), a leading French research institution, under the supervision of Dr. Laurent Cognet expert in the single particle tracking of nanoobjects. The proposal contains well-identified work packages which will ensure efficient science development but also project management, career development, training, technology transfer and communication. The fellow’s expertise, the hosting lab, the infrastructure, facilities and the mentoring will g
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Cfsp and human rights'.

assistant: **Innovation**

Research objectives and content program. The general scientific objectif are singularities of foliations, researchers. The teams in the network produce each year around ten Ph.D. dynamical systems or more general differential equations over the real or each of them gets easily a permanent position. The total amount of the budget directly devoted to the training of young people is around 1/3 of complex numbers. There are three main lines of work: reduction of singularities, differential Galois theory and geometry of the the total requested financement. The external (inside Europe) relations, as well as the amount of young researchers involved in the network, singularities. guarantees the existence of young researchers to be trained. The main tools we use are deformations, singular perturbations, group actions as group of diffeomorphisms, local algebra, cohomological methods, differential algebra and asymptotic developments. The proposed network is composed by seven teams with a big amount of previous scientifical connections and work in common on the proposed objectives. Many of the basic results in that directions come from join works of team's members.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Linking Cardiometabolic Disease and Cancer in the Level of Genetics, Circulating Biomarkers,  Microbiota and Environmental Risk Factors' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cardiovascular disease (CVD), type 2 diabetes (T2D) and obesity, collectively referred to as cardiometabolic disease, together with cancer are the major morbidities and causes of death. With few exceptions, research on cardiometabolic disease and cancer is funded, studied and clinically applied separately without fully taking advantage of knowledge on common pathways and treatment targets through interdisciplinary synergies. The purpose of this proposal is to reveal causal factors connecting and disconnecting cardiometabolic diseases and cancer, and to understand interactions between gut microbiota, host diet and genetic susceptibility in a comprehensive prospective cohort study design to subsequently allow design of intervention strategies to guide more personalized disease prevention.1. We investigate causality between genetic risk factors for cardiometabolic disease associated traits and future incidence of T2D, CVD, cancer (total/breast/colon/prostate) and mortality (total, CVD- and cancer mortality), searching for causal factors in a prospective cohort with >15 y follow-up (N>30,000, incident cases N=3550, 4713, 5975, 6115 for T2D, CVD, cancer, mortality)2. For the first time in a large population (N=6000), we investigate how gut and oral microbiome are regulated by dietary factors, gut satiety peptides and host genetics, and how such connections relate to cardiometabolic disease associated traits and cancer 3. We investigate the role of diet and gene-diet interactions of importance for cardiometabolic disease and cancer 4. We perform genotype, biomarker and gut microbiota based diet intervention studies. This inter-disciplinary project contributes to biological understanding of basic disease mechanisms and takes steps towards better possibilities to prevent and tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'NANOSCALE INTEGRATED CIRCUITS USING ENDOHEDRAL FULLERENES' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

This project will develop a new family of devices and systems which may lead to radically new alternatives to integrated circuit manufacturing, materials and design in contrast to currently forecast ultimate silicon technologies. The proposed novel circuits rely upon the molecular and atomic properties of the fullerenes and endohedral fullerenes for their manufacture and operation. The development of the technology requires new device concepts and novel new architectures for logic and memory operation. Device fabrication will be performed on the scale of tens of nano-meter range and memory cells with dimension of a nanometer, the ultimate limit set by the size of the fullerene cage, will be assessed using a novel new nanofabrication technique. To achieve this goal, a gathering of expertise from the fields of physics, chemistry, materials science, nanotechnology and microelectronics will be leveraged to solve the trans-disciplinary nature of the work.This project will develop a new family of devices and systems which may lead to radically new alternatives to integrated circuit manufacturing, materials and design in contrast to currently forecast ultimate silicon technologies. The proposed novel circuits rely upon the molecular and atomic properties of the fullerenes and endohedral fullerenes for their manufacture and operation. The development of the technology requires new device concepts and novel new architectures for logic and memory operation. Device fabrication will be performed on the scale of tens of nano-meter range and memory cells with dimension of a nano-meter, the ultimate limit set by the size of the fullerene cage, will be assessed using a novel new nano-fabrication technique. To achieve this goal, a gathering of expertise from the fields of physics, chemi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Ubiquitin-Proteasome System crosstalk with Metabolism', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cellular metabolites are essential components of life processes, and their import, biosynthesis, and enzymatic conversion are regulated by a wealth of pathways. The ubiquitin-proteasome system (UPS) plays a major role in ensuring that key metabolic regulators are maintained at proper levels, to control concentrations of ions, carbohydrates, amino acids, cofactors, and lipids. In particular, the activities and localization of critical ubiquitination enzymes (E3 ligases) and the proteasome must be tightly regulated to ensure that degradation is restricted to proteins that are unwanted, superfluous, or toxic, while sparing those proteins needed for ongoing metabolic functions. Nonetheless, we have limited knowledge of fundamental structural and cellular mechanisms underlying this regulation, and the extent of crosstalk between E3 ligases and metabolic signals. The main aim of this proposal is to decipher molecular principles underlying crosstalk between ubiquitination and metabolites at large. By using time-resolved cryo EM, single-molecule biophysics, cell-based mutagenesis screens and functional studies, we will provide insights into how E3 ligases regulate key mediators of glucose, ion, and lipid homeostasis (Aim 1). To further increase knowledge of the breadth and depth of crosstalk between metabolic pathways and the UPS, we will use our toolkit of E3 ligases and probes to define regulatory interactions between a wide swath of metabolites and E3 ligases, and to identify E3s activated upon switches in metabolic conditions (Aim 2). Moreover, we will explore how E3 ligases and proteasomes are reorganized at an ultrastructural level inside cells to respond to starvation or nutrient-rich conditions (Aim 3). Taken together, these interdisciplinary approaches will establish a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Magnonics meets micro-electro-mechanical systems: a new paradigm for communication technology and radio-frequency signal processing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The M&MEMS project aims at combining the tunability of magnonic systems with the power efficiency and the agility of micro-electro-mechanical systems (MEMS), thus empowering a new generation of devices for radio-frequency (RF) communication and microwave signal processing. The consortium brings together 7 EU research groups and 2 industrial partners with a broad range of leading expertise in the fields of magnonics, MEMS, material science and RF electronics. We will first optimize the individual magnonic and MEMS building blocks by simulations and experiments. Then MEMS actuator with permanent magnets will be integrated in standalone PCB demonstrators for the first time. Such M&MEMS chip, which have the capacity to disrupt the wafer-scale based hardware industries, will serve as the cornerstones of a new technology platform bringing spin-wave devices to a new level in terms of energy efficiency, agility, reconfigurability and footprint. Two analog RF electronic functions have been identified by our end-users: an agile-filter with potential application in the field of 5G communication and beyond (NOKIA) and a programmable phase shifter array, the building block of novel directional antenna (Thales). A dedicated Advisory Board (including Rohde & Schwarz and ST Microelectronics) will support the two end-users, having the mission to investigate other possible applications and eventually produce the Roadmap “Beyond M&MEMS”.


**Keywords:** magnonics, spintronics, micro-electro mechanical systems, surface acoustic wave, phase shifter, agile microwave devices
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Diagnostic HER2DX-guided treatment for patients with early-stage HER2-positive breast cancer' to be submitted under Horizon Europe.

assistant: **Abstract**

HER2+ breast cancer affects around 390.000 women annually worldwide (i.e. 3 patients every 4 minutes). Over the last decade, polychemotherapy and HER2-targeted therapies have improved patient´s survival; however, the reality is that most patients are cured with less intense, toxic, and costly drugs. Up to now, no diagnostic test existed to guide the optimal therapy for each patient. The 27-gene HER2DX test (TRL8) is a novel minimally invasive diagnostic tool which provides unprecedented predictive information for therapy optimization in early-stage HER2+ disease. The DEFINITIVE project will prospectively validate HER2DX`s clinical effectiveness, proving its ability to significantly i) reduce toxicities, ii) improve quality of life and ii) reduce direct and indirect costs, while maintaining efficacy endpoints and survival outcomes in patients with early HER2+ breast cancer.DEFINITIVE will combine international experts in breast cancer from international reference hospitals, comprehensive cancer networks, regulatory, HTA and medical statistics experts, SMEs, policy makers, patient associations, living labs and medical society networks. DEFINITIVE consortium will conduct a pragmatic clinical trial across 44 centres in 7 European and associated countries to randomize 304 patients with stage II to IIIA HER2+ breast cancer, in a 1:1 manner, and to be treated with the result of the HER2DX test to guide treatment vs without the result of the test (treatment by physician´s choice according to local guidelines). The inclusion and exclusion criteria will be very broad to make sure that most patients can participate in the trial and the results could be generalized to the overall population treated in real-world settings. Beyond seeking the endorsement and implementation of HER2DX
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Learning 4 Security' in the context of a Seventh Framework call.

assistant: **Objectives**

Effective collaboration dynamics are at the core of crisis management in the transportation sector. Nevertheless, in today’s global environment, a very large number of crisis management initiatives fail to deliver the value expected, as the collaboration challenges in crisis are very high. This is because of the complexity of the knowledge integration processes as well as the diversity and distributed nature of the people, groups and knowledge involved in the management of crisis under high pressure of time. Thus, effective crisis management requires collaborative crisis management competencies at the individual, team, organizational as well as the inter-organizational level. The project builds on interdisciplinary scientific / academic models and best / worst practices and experiences to identify the factors inhibiting effective collaboration in crisis situations in the transport sector (“Collaboration Traps & Challenges in Crises”), and the interventions required to reduce these risks (“Collaborative Crisis Management Competencies”). After integration, this know-how will lead to the development of: • An innovative framework (Advanced Collaboration in Crisis Management – ACCM-Framework), addressing the effective development of collaboration competencies for the specific challenges of crisis management in the transportation sector. • A set of widely deployable, advanced, interactive and experiential technology-enhanced solutions (“ACCM Simulation Games”) guaranteeing the effective understanding and internalization of collaborative decision making processes (1) under extreme time pressure, (2) facing the lack and asymmetries of information, (3) dealing with the diversity and emotions of people, and (4) effectively addressing the interpersonal dimension of speed-relations