RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Fire resilience of Amazonian forests:  past, present and future'.

assistant: **Objectives**

The challenge. Despite a global decline in burned area, total CO2 emissions from fires have increased due to more fires in previously largely fire-free and therefore fire-sensitive forests. Existing knowledge of fire impacts comes from fire-adapted ecosystems and cannot be easily translated to fire-sensitive forests. Particularly the Amazon has seen recent increase in fire frequency and intensity, with devastating local effects on the forest, regional-scale air pollution, and global CO2 rise. Aim. I aim to understand fire resilience – i.e. resistance to fire and post-fire recovery – of fire-sensitive ecosystems by studying the Amazon. I will assess fire resilience at multiple temporal scales: 1) the past to understand long-term recovery and full disturbance-recovery cycles, 2) the present to experimentally understand mechanisms underlying fire damage and mortality, and 3) the future to Amazon resilience to future fire regimes. Approach. I will integrate across temporal scales and their different disciplines. For past fire resilience (last 10,000 y), I will use paleo pollen and charcoal records. For present fire resilience, I will build a monitoring network in burned forests and perform a unique fire experiment. For future resilience, I will use the previous steps to adapt a dynamic forest model and simulate future fire resilience. I will quantify fire regime as fire frequency and intensity, which are fundamentally different aspects of fire regime but rarely tested simultaneously. To assess how climate drives fire resilience, I will study seasonally dry and wet evergreen tropical forests. To understand mechanisms underlying tree mortality and recovery, I will use physiological measurements and plant functional traits to understand species and community resilience in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of the SNP-induced RNA structure variations between subgenomes in polyploid wheat' (INSPIRATION).

assistant: **Concept**

Polyploidization is one of the major driving forces of plant evolution and crop domestication and plays a key role in plant environmental adaptation. The function of multiple gene copies (homoeologous genes) from different subgenomes can vary from each other (sub/neofunctionalization), which is considered as the key to understanding polyploidy evolution and environmental adaptation. However, most sequence variations between homoeologous genes lie on the non-coding region or are synonymous mutations, which cannot lead to codon change. To data, very little is known about how the vast majority of sequence variations over the gene body regions drives subgenomes sub/neofunctionalization in polyploidy.Recently, Single Nucleotide Polymorphism (SNP) induced RNA structural alteration is demonstrated to play key roles in post-transcriptional regulations such as RNA decay and splicing. Further studies in human disease showed that SNP-induced RNA structural changes are associated with diverse human disease and phenotypes. And also, temperature can affect the RNA structures that more stably folded mRNAs tended to show lower decay rate. This brought attention to the existing function of synonymous mutations as well as non-coding SNPs. Thus, I hypothesize that SNP-induced RNA structural alteration might lead to the subgenomes sub/neofunctionalization and play an important role in temperature stress response.As tetraploid wheat is widely grown in the Europe and its yield is severely affected by heat stress, I will test my hypothesis in tetraploid wheat. Firstly, genome-wide RNA secondary structure profiling will be applied to compare SNP-induced RNA structure variations between subgenomes in tetraploid wheat. Secondly, I will investigate the roles of SNP-induced RNA structure variation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Breaking the Silence: Archaeological Discoveries and the Making of Public Slave Heritage in Rio de Janeiro' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

SLAVHERIT aims to understand how slave memory, after long institutional oblivion, is being publicly memorialised in Rio de Janeiro. This process of memorialisation is considered to be in line with recent multicultural trends in Brazil, by enhancing the visibility of Afro-descendants in national history. That said, no literature has explored this process critically within the existing context of Brazilian racial politics. In addition, no literature sees how this slave heritage is actually being built, what it represents for different social actors, and which power relations prevail in its establishment. SLAVHERIT addresses these questions in an original way, taking an interdisciplinary approach that combines the fields of history, anthropology and politics. In doing so, the project deals with slavery not as a fact locked in the past but as a process relevant for political uses of memory in the present. While focusing on Brazil, SLAVHERIT will lead to conceptual and methodological contributions that will also be interesting for other contexts. In Europe, in fact, multicultural inclusion is an ongoing and heated issue in policy making, while studies of memory are flourishing and the legacy of Atlantic slavery on persisting social exclusion in European societies is increasingly being considered. Through a range of competencies to be achieved in Brazil, SLAVHERIT will broaden the applicant’s expertise in the study of race relations and slave memory in Latin America, producing skills for his effective reintegration into the United Kingdom as a researcher, academic and consultant in the proposed field. SLAVHERIT will also encourage the circulation of knowledge between Brazil and Europe, contributing to European excellence in Latin American studies, and increasing Brazil’s pres
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Engineering and expression of secretory immune complexes in plants for mucosal vaccination' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content high energy saving potential compared to separation techniques like distillation, were compared in the Joule 1 project. Layer processes are proven technology, but their relatively low separation efficiency leads to a strong reduction of the energy efficiency. The energy saving and separation potentials of a single step suspension process are better. However, the complete separation of the pure crystals from the impure mother liquor is essential for the utilization of these potentials. Therefore the ongoing Joule 2 project focuses on the application of wash columns as solid-liquid separation devices coupled to a suspension crystallizer. For a number of systems, like phenol and p-xylene, the technical feasibility of such a combination has been proven. Pilot plant experiments in the Joule 2 project will be started soon. However, for a number of industrially important bulk chemicals the size (distribution) and/or the shape of the crystals which are formed in a suspension crystallizer to the column is yet nog good enough to apply wash columns directly. Examples of such chemicals are e.g. caprolactam and bisphenol A. Cooling belts and wash columns are technically proven unit operations. In the proposed research project these technologies will be combined for the first time for the development of a widely applicable MC process. It is expected that the impurities from a feed melt are concentrated in grain boundaries in the granules during solidification on a cooling belt. The granules have a relatively large specific surface area compared to a solid layer and comparable to that of crystals in suspension-based MC processes. Due to this increase in surface area it is expected that the removal of impurities from the granule by means of mechanisms li
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'In silico design and assessment of novel polyelectrophylic chemotherapy agents' under Horizon 2020.

assistant: **Concept**

Administration of DNA-damaging reagents constitutes one of the most effective chemotherapeutic strategies for the cancer treatment. The families of drugs developed over the years for this purpose are based on second-order nucleophilic substitution (SN2) reactions. Innovative candidates to improve the therapeutic action of these compounds have been designed based on increasing the number of electrophilic positions (En) of the reagent by making n>2. This increased electrophilicity must generate interstrand crosslink adducts that should result in irreversible lesions in the DNA of cancer cells.  Computational chemistry tools based on quantum mechanics and molecular modelling, constitute key tools for a better understanding of DNA damage and repair after the formation of the covalently bound complexes that distort the double helix. Thus, the aim of the project described in this proposal is to: 1) compute the structures and evaluate the distorting effects of DNA adducts with polyelectrophilic chemotherapeutic reagents, 2) compute the kinetics of the consecutive SN2 processes (on both carbon atoms and metallic centres) involving interstrand and intrastrand crosslinks and 3) assess in silico the ADME (Adsorption, Distribution, Metabolism and Excretion) properties of the synthesised candidates. Those objectives will be achieved by computing the behaviour of different families of molecules through quantum mechanical - at DFT level of theory- and Molecular Mechanics calculations - based on QM/MM method. Some of these candidates have been synthesised in the laboratories of the hosting group and the corresponding preliminary and promising biological results are already available. The outputs of this project will result in a patent proposal and research articles to be published in h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular and cellular basis of signalling pathways in primary nociceptive neurones' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content  The project will investigate the cellular and molecular bases of signal transduction in primary pain-sensitive neurones (nociceptors). Sensory transduction in nociceptors is poorly understood by contrast with transduction in other sensory receptors. The project will extend our understanding of a sensory system which is in many ways different from others. A better understanding of the mechanisms involved in the encoding of painful stimuli will also be of benefit in the development of improved analgesics and in the treatment of chronic pain.  The principal focus will be on the intracellular signalling pathways in pain-sensitive neurones which underlie the responses to the following pain-causing (i.e. algogenic) stimuli; (i) the peptide bradykinin, which is known to be released after tissue damage. Bradykinin serves the dual function of both causing pain and of enhancing the pain caused by other stimuli. (ii) noxious heat, which has been shown by the host group to activate an inward membrane current in nociceptors. The inward current is enhanced by bradykinin in a process which involves activation of protein kinase C. The project will use sensory neurones isolated and maintained in culture. These neurones have been shown by the host laboratory and others to duplicate in many respects the properties of pain-sensitive neurones in intact animals, and they offer a convenient and powerful method for studying the cellular and molecular bases of the pathways responsible for transducing a painful stimulus into electrical excitation of the pain-sensitive neurone and subsequently into a sensation of pain. Responses of neurones to the stimuli outlined above will be dissected using electrophysiological techniques (whole-cell patch clamp) calcium imagin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modern EPR spectroscopy-methodology and applications in physics, chemistry and biology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This application is for a Euro summer school on modern Electron-Paramagnetic Resonance (EPR) spectroscopy. EPR is the most effective tool for structural and dynamical characterization of paramagnetic substances. It is used in a broad range of research fields such as stable and transient free radicals, metalloproteins and metalloenzyms, radiation damage in DNA, heterogeneous catalysis, new materials, nanostructures, semi-conductors, and excited states. EPR spectroscopy is also very active in the areas of complex fluids, self-assembled systems, membranes and proteins, are investigated through the introduction of spin-labels. With the recent exciting advances in the Human Genome Project it is expected that EPR spectroscopy will play a significant role in the characterization of the structure and function of metal sites in new proteins and in enzymatic reactions involving radicals. EPR spectroscopy has witnessed during the last 15 years tremendous methodological and instrumental developments primarily in the directions of high field EPR and pulsed EPR.These include multi-frequency, multi-resonance and multi-dimensional experiments, in the spirit of the developments that revolutionized the field of NMR spectroscopy. These advances increase considerably the information content of EPR measurements and has therefore impacted various areas of chemistry, materials, physics and biology. The objectives of the school is to disseminate modern EPR methodology to the scientific community through its young researchers. It will effectively expose young scientists to the newest methodological and instrumental developments in EPR spectroscopy along with novel research applications, and it will give them the theoretical tools that are essential for the comprehension of the various technique
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Solutions @ Underwater Radiated Noise' (SATURN) under Horizon 2020.

assistant: **Objectives**

The SATURN consortium brings together leading experts in bioacoustics; population biology; marine mammal, fish and invertebrate biology; maritime architecture and engineering; shipping; maritime policy; stakeholder engagement and science communication. We will combine expertise from these disciplines to work with unity of purpose and clarity of intent to identify:a.The sounds that are most detrimental to aquatic species and how they are produced and propagated;b. The short-term and cumulative long-term negative impacts of noise from shipping and boats on three representative groups of aquatic species in rivers and the sea (invertebrates, fish and marine mammals); c.The most promising options for measuring and reducing the negative impacts of ship noise that can be applied to current and future vessels. SATURN will develop and contribute to the establishment of standards for terminology and methodology to be used across all disciplines working on underwater radiated noise. These standards will underpin the proposed research. The consortium will establish and nurture an effective community of researchers, practitioners, competent authorities, maritime operators, shipping/offshore/naval industries, and NGOs. This group will work closely with the project to ensure that outputs are tailored to the needs of all stakeholders and to maximize their uptake and application. SATURN proposes to confront the complex global issue of underwater radiated noise in a truly inclusive, transdisciplinary way that will ensure that the interests and knowledge of all stakeholders and the environment are represented.


**Keywords:** Underwater noise,  anthropogenic noise,  shipping,  ship noise,  mitigation,  impacts, standards
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'ParcelCall - An Open Architecture for Intelligent Tracing Solutions in Transport and Logistics' to be submitted under Fifth Framework.

assistant: **Abstract**

ParcelCall will develop and verify an open architecture for intelligent tracking and tracing in transport and logistics. New network technologies will be combined with advanced sensors and innovative service engineering. ParcelCall provides a generic answer to a range of similar applications in other areas (health care, emergency services, surveillance, etc.). Its consortium covers all key competencies: leading edge users, software developers, equipment manufacturers, and research. The project work builds on the state of the art and develops specific answers to overcome key constraints for the realisation of the objectives in an open system approach. This relates specifically to seamless integration for intermodal transport, use of active sensors, and intelligent sensor networks.Objectives:The objective of ParcelCall is to realise an intelligent end-to-end tracking and tracing solution across all boarders of carrier and transportation modes. It will optimally draw on emerging technologies, e.g., Radio-Frequency Identification (RFID) tags, and public communication networks (Internet and GPRS) to develop the system and trial the application in a realistic business context. Standard mobile phones will be used, any time and anywhere, to get near real-time tracing information along the complete logistic chain. The approach distinguishes three levels with increasing performance, flexibility, and scalability. Firstly, development of an open tracking and tracing architecture across the complete logistic chain. Secondly, integration of active sensors, providing the means to monitor and control environmental conditions and quality status of transport goods. Finally, incorporation of communicating sensors providing alert messages directly to the goods owner if environmental condit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimising the trade-offs between biodiversity value and human value' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

At the 2002 World Summit on Sustainable Development, the nations of the world agreed on ambitious targets for the future of the planet, including goals such as eradicating extreme poverty and hunger, and ensuring environmental sustainability. Yet, ensuring the preservation of the world's natural resources while improving human welfare will require an unprecedented compromise between human use and biodiversity conservation.This Project explores the trade-offs between biodiversity value and human value, and how to maximise mutual benefit. It tests how the shape of the relationship between human and biodiversity values is affected by the way each of these variables is measured, and the implications for traditional views of sustainable development. This Project further investigates ways of maximising these trade-offs through variations in the spatial configuration of the different types of land-use. This Project is therefore at the interface between conservation science and socio-economic sciences.Through the analysis of existing data and case-studies, it will advance the scientific understanding of how regional land use planning strategies can simultaneously ensure human welfare and preserve biodiversity. The focus of this Project is thus on Sustainable Development, one of the seven research priorities of the Sixth Framework Programme. Its results will be directly relevant to support of European policymaking in the implementation of the EU Strategy for Sustainable Development.This project will further contribute to the objectives of the Sixth Framework Programme by promoting the mobility of researchers within the EU, strengthening Europe's human resources and research capacity in the field of conservation biology, fostering the participation of women and young people in re