RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Relativistic non-linear optical property calculations with density functional theory' in the context of a Horizon 2020 call.

assistant: **Objectives**

Non-linear optical properties of molecules with strong relativistic effects play an important role in current research e.g. for photochromic materials and bioimaging. Up to now, there is no computational treatment of these molecular properties such as two-photon absorption (TPA) and first hyperpolarizabilities using density functional theory (DFT). Such a computational technique will, however, be very benefitial for research in this field as by result prediction and computational assistance for the interpretation of results, it will allow for a much more efficient use of synthesis ressources both regarding manpower and chemicals. The molecular properties will be treated in terms of energy derivatives w.r.t. the electric field using response theory. Relativistic effects will be taken into account as part of the zeroth-order Hamiltonian. Namely, the four-component Hamiltonian will be used. As the first main task of the project, the so-called second exchange-correlation kernel, the third derivative of the exchange-correlation energy with respect to the variational parameters, will be formulated and implemented. Due to the innovativeness of the response theory approach to be used, TPA, first hyperpolarizabilities and excited state dipole moments will be available at the same time allowing for a large variety of applications right from the start. This project is a big challenge for quantum chemical method development as taking into account relativistic effects using the four-component Hamiltonian operator renders the fundamental expressions very complex. However, the risk behind this project will be minimized by the organization in terms of work packages which ensure that the implementation will be performed in different steps with increasing complexity.


**Keywords:** resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Democratized Cryo Electron Microscopy Image System' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

DeCEMIS will bring to full technical maturity and commercial readiness the world’s first low energy detection system optimized for Cryo Electron Microscopy (CryoEM).  CryoEM is an emerging and key enabling technology for reliable and cost-effective structural molecular analysis. The DeCEMIS FTI project will give more users world-wide access to CryoEM, leading to the development of new drugs and vaccines in Life Sciences and next generation of solar cells, batteries and catalysts in Material Sciences.CryoEM is becoming the gold standard for molecular structural analysis. Compared to alternative existing structural methods (e.g. X-ray crystallography or Nuclear Magnetic Resonance), CryoEM offers higher analysis flexibility and accuracy, particularly for heterogenous and radiation sensitive samples such as proteins and polymers. Among other achievements, CryoEM recently determined the first ever molecular structure of the COVID19 spike protein, providing key information for development of vaccines.Today, high-quality CryoEM structures are most commonly obtained using high energy, 300 keV microscopes, which due to their complexity and cost are accessible to only a limited number of research laboratories worldwide.Our innovative, direct detection Swift camera, based around a high-speed, wafer-scale CMOS image sensor, will enable high-quality molecular structure determination using less expensive 100keV CryoEM microscopes at a competitive price-to-performance ratio. By maturing our prototype for commercialization, the DeCEMIS project will pave the way for a new series of more affordable 100 keV Transmission Electron Microscopes with accessible, high-quality detection, aimed at making cryoEM available to more scientists.Commercialisation of the Swift direct detection camera wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation and Internationalisation services by BENE – I²BENE' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The project aims at offering specific services to 2 different groups of SMEs based in the Brussels Capital Region:the SME Instrument beneficiaries and the SMEs having a high potential for growth and internationalisation by the enhancement of their innovation management capacity. These services will be an integral part of Enterprise Europe Brussels services.Although for the SME Instrument beneficiaries, the proposer depends on the number of successful SMEs granted, a funnel approach will be adopted for both SMEs Groups in order to have an upstream estimation and selection of the SME potential existing in the region.  This funnel and selective approach will also take into consideration the permeable frontiers which divide one SME group from the other, in light of the innovation needs and capacities at a given time of the SME lifecycle.The service provision for Group2 will be ensured via a structured process of SMEs pre-selection, set up according to a pre-defined methodology which relies on ad-hoc tools and processes, designed with the aim to select only those SMEs with the capacity, clear intent and ambition to benefit from the innovation management assessment. The pre-selection tool is based on 8 criteria: each of them has been attributed a weight according to its importance. In function of the score obtained in these different areas, the SME will be selected (or not) to benefit from the innovation management capacity assessment through the Imp³rove methodology.The I²BENE proposal addresses the obstacles which hinder Brussels-based SMEs from being more competitive, from growing and creating new jobs, thus having a real impact in the regional economy, and establishing a link between the research development process and the uptake of innovative products by SMEs. The ident
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Creation of modular cell factory for the production of high value chemicals towards Null-pollution' (Null-ution).

assistant: **Innovation**

Towards a better future with less pollution, better life quality for humans, animals and plants and more sustainable high-value chemicals under a modular biological system. Microorganisms (Clostridium sp.) will be the driving force, and carbon dioxide (CO2) will be the fuel required to grow and produce the high-value chemicals. The modularity will allow the same organism to act as a multi-product factory, based on the benefit and requirements. We aim to select the Clostridium sp. based on their ability to capture CO2. Enzymes involved in CO2 metabolism will be subjected to improvement; either the same enzymes will be mutated or substituted by a better biocatalyst from the natural inventory. Once satisfactory CO2 utilization/organism growth levels are achieved, designed constructs targeting specific pathways will be transformed into the recombinant organism to validate their modularity. We have selected bioplastic and butanol as the target model products. Consequently, new genes will be assembled into a single plasmid and subsequently transformed into the microorganism. The product levels and efficiency of the new system will be evaluated.


**Keywords:** Utilizing synthetic biology and systems biology to create an adaptive microorganism capable of using carbon dioxide and producing industrially relevant high-value chemicals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improvement of the clinical applicability of tissue-engineered vascular grafts, as new regenerative therapy for children with congenital cardiovascular malformations' under Seventh Framework.

assistant: **Concept**

Currently available artificial graft prostheses for congenital disorders lack the capacity of growth and often require complex and reconstructive surgical interventions. As a consequence, repetitive and high-risk surgical interventions during childhood are inescapable, associated with increased morbidity and mortality. This not only raises enormous costs for the society, but compromises the quality of life of the young patients. Therefore, manufacturing Living Vascular Grafts is the ultimate goal for both cardiovascular researchers and clinicians. Tissue engineering is an opportunity to create prostheses that are vital, growing, adaptive, and autologous and show optimal functionality. Such in-vitro tissue-engineered vascular grafts have demonstrated functionality and growth as pulmonary replacement in lambs. However, classical tissue engineering using autologous cells, necessitates invasive cell harvesting from the patient, time consuming cell expansion and production of the patient-specific graft. As the living cellular component of the grafts inherently limits clinical applicability, an accelular equivalent with corresponding strength, growth, and regenerative capacity, would provide an attractive alternative for the living tissue-engineered vascular grafts.  Therefore, my goal is to improve the clinical applicability of the tissue-engineered pulmonary grafts by decellularizing them, therewith creating novel off-the-shelf constructs for children with congenital cardiovascular malformations. The in-vivo recellularization capacity of these accelular tissue-engineered pulmonary grafts will be evaluated in a pre-clinical animal model to demonstrate their potential to grow with the recipient. These innovative alterations to create unlimited off-the-shelf grafts will speed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Support to the activities of the European Technology Platform on Renewable Heating and Cooling' under Seventh Framework.

assistant: **Concept**

This proposal aims at establishing a secretariat to support the activities of the European Technology Platform on Renewable Heating and Cooling. Such a Platform was launched in December 2008 with a view to bringing together stakeholders from the solar thermal, biomass and geothermal sectors, as well as related technologies (e.g. heat pumps, construction, district heating and cooling), to draft a common research and policy strategy for the whole renewable heating and cooling sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Inflection Bioscience unique dual mechanism, small molecule, orally available therapeutic targeting major unmet medical needs in breast cancer'.

assistant: **Concept**

Breast cancer is already a leading cause of death among women and most common form of cancer among European women with almost 500,000 cases in 2012 and over 1.7 million new cases globally. However, despite good progress in treatment options over the past decade, including some progress with immunotherapies, the war is far from won, with over 20% not responding to current standard care, and with the incidence of breast cancer set to rise by a massive 50% by 2030. There is now an urgent need for new effective, safe and life extending therapeutics for those women suffering and dying with breast cancer. IBL-302 is a first-in-class small molecule targeted breast cancer therapeutic that targets both the PI3K and PIM pathways. It is anorally bioavailable pan-PIM kinase, pan-PI3K and mTOR inhibition in a single agent. As the PI3K pathway is one of the mostcommonly mutated pathways, this multi-path action effect closes down the main route of mutation and a primary backup PIMpathway. This confers the promise of much greater rates of efficacy and potential utility to combat the breast cancer epidemic.Inhibition of the PI3K pathway alone is cytostatic, it pauses cell growth but does not kill cancer cells. This has the effect ofthe PIM pathways then being activated as a backup mutation pathway, allowing the cancer to progress once more. AddingPIM inhibition on top of the PI3K inhibition actually induces apoptosis, the death of cancer cells instead of simply stallingtheir growth.A development partnership will be sought with a large pharmaceutical company to complete final stages of clinicaldevelopment required for market approval. The partner will also be responsible for the manufacture and distribution IBL-302on an exclusive licence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IMPact SHIELD design C' in the context of a Seventh Framework call.

assistant: **Objectives**

This proposal is to design and manufacture an innovative shield to protect critical components of an aircraft against high velocity shrapnel from an engine burst.The concept of the shield design is based on in house modelling capabilities of Imperial consultant to use different fibres acting as membranes through the thickness of the ballistic structure.  In addition to this, these fibre layers are interlaced by foam to provide optimum performance. This use of almost dry layers within foam sub-laminates will be investigated at the modeling stage.  The specific polymer used will depend heavily on the temperature requirements as well as other aircraft integration constraints and hence will be subject to more detailed discussions.  The manufacturing is provisionally done by press with matrix film layers.  The specific matrix used will again subject to the temperature requirements.The proposal has come from a close collaboration between the Imperial College Consultants and Swerea SICOMP.  It is therefore the result of the combined skills in manufacturing structural composites for the defence and aeronautical industry as well as specific ballistic design skills.  Both institutes have the necessary skills, experience and equipment to design and manufacture a successful shield.  As both these institutes are non profit research establishments actively working to advance composite technology, the materials and techniques have been chosen based on the type of treat and the aircraft integration constraints and there is no constrain to use any one particular material supplier.  Publishing and dissemination of the results is also not a problem if so desired.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The evolution of mesoderm and its differentiation into cell types and organ systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mesoderm, the embryonic germ layer between ectoderm and endoderm, gives rise to major organs within the circulatory and excretory systems and to stabilizing tissues (muscles, bones, connective tissue). Although mesoderm is a key-innovation in evolutionary history, its origin and further diversification into the different organs and cell types of a broad range of animals has not been elucidated. Our knowledge of mesoderm development is mainly based on work performed in prominent model systems including vertebrates (fish, frog and mouse) and invertebrates that are distantly-related and considered to be highly derived (Drosophila and C. elegans). The project proposed herein aims to study mesoderm development in a variety of highly informative animal taxa and trace its differentiation into cell types and organs, with the ultimate aim of reconstructing the history of mesoderm during animal evolution. Our approach combines advanced bioinformatics, live-imaging and molecular methods, and will be carried out in nine representative species belonging to under-investigated animal groups. We will describe the morphological and molecular development of mesoderm in these species, and the differentiation of two important mesodermal cell types: nephridia and blood. Using this information we will be able to infer the embryology and mesodermal cell type composition of ancestors at six important nodes in the animal tree of life. We will also be able to comprehend when shifts in mesoderm development have occurred and how these shifts have remodeled the animal body plans. Further, our implementation of advanced methods in under-studied species will provide new model systems and a more comprehensive framework for further studies in evolutionary developmental biology as well as in other resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Host-parasite relationship in susceptibility to tuberculosis'.

assistant: **Objectives**

Vaccine candidates are emerging but the time and cost of TB clinical trials prohibits their evaluation. Surrogate markers are needed. Cells from carefully followed up contacts who do or do not develop disease are being studied forcytokine expression by RT-PCR in 3 African centres. VACSIS will add a 4th centre, upgrade technology to real time RT-PCR, and study markers of apoptosis that play a role in immune response regulation in TB. Meanwhile patients TB strains will by typed for polymorphisms in DNA repair genes, and this will be related to disease severity, transmission and immunology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Key elements for application of microreactors in multiphasic catalytic chemistries' under Fifth Framework.

assistant: **Concept**

The proposed programme will develop technologies which demonstrate microreactor implementation for 'high speed chemistry'. This dramatically improves the effectiveness of chemical syntheses. The programme will design, fabricate and demonstrate High Throughput Experimentation (HTE) systems. The devices will rapidly optimise catalysts and new chemical syntheses in three selected real world applications: The formation of multiple stock chemicals from methane, synthesis of optimised new functional chemicals for oil field operations and asymmetric chiral synthesis of pharmaceutical precursors. The project will also explore via a number of risk reduction projects, the means by which these devices can be used to rapidly scale up synthesis through parallel scale out of novel microreactor-based plant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Flexible labour markets - the issue of European convergence and divergence' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Research objectives and content The objective is firstly to create an 'empirical based' theory of the effects of atypical forms of work on the organisational structure/ human resource management of firms. The second aim is to investigate how society as a whole is effected by those forms of work, i.e. social inclusion and exclusion of disadvantaged groups. The research is designed to show the options for policy makers in the member states, in the light of changing working patterns. Special attention will be paid to the question of European convergence and divergence. Training content (objective, benefit and expected impact) The objective of the training is to make effective use of data produced by the different disciplines involved in labour market management. The benefits of the approach will be to facilitate the transfer from academic work into practice Links with industry / industrial relevance (22) The host institution has close links with industry. For the execution of parts of the project active involvement from industry will be sought.